{
  "default_seeds": [
    42,
    123,
    456
  ],
  "num_candidates_per_seed": 100,
  "num_batches": 1,
  "num_steps": 1500,
  "warmup_steps": 100,
  "guidance_strength_beta": 5.0,
  "top_k": 50,
  "temperature": 1.0,
  "position_sampling": "weighted",
  "use_acceptance": false,
  "fix_termini": "cooh",
  "fast_scoring": true,
  "weights": {
    "synthetic_accessibility": 4.0,
    "chemotype_closeness": 2.0,
    "connectivity": 4.0
  },
  "weights_positional": [
    4.0,
    2.0,
    4.0
  ],
  "targets": {
    "EGFR-VHL": {
      "protac_module": "ErlotinibVHL",
      "warhead": "gefitinib-piperazine (MS39)",
      "e3": "VH032"
    },
    "BRD9-VHL": {
      "protac_module": "BRD9VHL",
      "warhead": "BI-7273-piperazine",
      "e3": "VH032"
    },
    "CDK6-CRBN": {
      "protac_module": "CDK6CRBN",
      "warhead": "palbociclib-piperazine",
      "e3": "pomalidomide"
    }
  }
}