{
  "protocol": "split-first-v1",
  "method": "conditional_mlp",
  "data_meta": {
    "reference_fraction": 0.1,
    "protocol": "split-first-v1",
    "dataset": "norman",
    "name": "norman",
    "operation": "activation",
    "control_label": "control",
    "sep": "_",
    "split": "perturbation",
    "seed": 0,
    "input_scale": "counts",
    "raw_sha256": "21bd3c00b7f243d998aa9ca616490b45bf1b4ba9934d501190a867ddad982dae",
    "raw_file": "norman_small.h5ad",
    "n_cells": 920,
    "n_control": 120,
    "n_hvg": 201,
    "n_pca": 10,
    "pca_explained_var": 0.5626983046531677,
    "mmd_gamma": 0.06974897265608301,
    "fit_cell_ids_sha256": "5ff57f6222cd8d3e4dd6b7fa658c8599cf6eb4b553a607ad9100a7fc240f9f22",
    "selection": {
      "max_cells": null,
      "max_per_group": null,
      "max_groups": null
    },
    "software": {
      "scanpy": "1.12.4",
      "anndata": "0.13.3.post0"
    }
  },
  "partition": "test",
  "catalog": "all",
  "reward": "cosine",
  "seed": 0,
  "n_controls": 8,
  "query_cell_ids": [
    "CCTTCCCTCACTATTC",
    "GTGGGTCAGTTAGCGG",
    "CAGCTGGTCGAATGCT",
    "ACAGCCGAGAGGGATA",
    "GGTATTGCACAACTGT",
    "ATGGGAGAGTCGAGTG",
    "CTGCGGAGTCTTGCGG",
    "GGCCGATGTATCACCA",
    "CGATTGAGTCTAGGTT",
    "TCTTTCCGTAGATTAG",
    "GACGGCTCACCAGCAC",
    "CAGCATAAGGCTAGCA",
    "AACTCTTCATGGTAGG",
    "AGCTCCTGTTCCTCCA",
    "GCGCAGTAGGATTCGG",
    "GTCTCGTGTGCATCTA",
    "GGTGAAGTCAGGTAAA",
    "CATTATCGTACTTAGC",
    "TGCGTGGGTCTCATCC",
    "CTGGTCTGTAGCGTGA",
    "TCACAAGGTCACAAGG-1",
    "GGCGACTCATTAGCCA",
    "GGGAGATAGAAGGACA",
    "GCGCCAACAGCCACCA",
    "TACGGTAGTACTTCTT",
    "CTCGAAAGTAGGCTGA",
    "CAGCCGATCCTTGACC",
    "GCTGCTTGTGAAAGAG",
    "CGCTGGAGTACATGTC",
    "GGCGACTCAGCTGTTA",
    "GCGCAACGTTGAGGTG",
    "CGGTTAAGTCAAAGCG",
    "AGCAGCCGTTAAAGTG",
    "TTAACTCCAGGGAGAG",
    "ATCCGAATCTGCTGTC",
    "ATCATGGAGGACGAAA",
    "CTGATAGCACTCAGGC",
    "AGCGGTCAGCACGCCT",
    "GCGAGAATCAGGTTCA",
    "CATTCGCCACCATGTA",
    "TTCGAAGTCGATAGAA",
    "AGAATAGCATTCCTGC",
    "AGCGTCGCACAAGACG",
    "AGGTCCGAGACTGTAA",
    "TATTACCAGACACGAC",
    "AAGGTTCCAGGAATCG",
    "ATTGGACCAACAACCT",
    "TGAGCCGGTCTCATCC",
    "AGAGCGACAGCTGTAT",
    "GGATTACCAAGTAATG",
    "AGCGTATTCGCGTTTC",
    "CGCTTCACAATCGGTT",
    "GGTATTGAGTGGACGT",
    "TAGTTGGGTTGGACCC",
    "GTACTTTTCGTGGGAA",
    "TTGCGTCGTTCGGCAC",
    "GTACGTATCAACGCTA",
    "TCGCGAGCACCTCGGA",
    "AGCATACTCAGCTCGG",
    "GCGCAACAGTGGGCTA-1",
    "GGAGCAATCCTATTCA",
    "GCACTCTTCAAACGGG",
    "ATTACTCAGGATGTAT",
    "CGACTTCTCCTTCAAT",
    "TGAGCCGAGAGTCTGG",
    "ACGAGCCTCGCATGGC-1",
    "CCCATACCAGGTCCAC",
    "CAGAGAGTCGTGGGAA",
    "CGTTCTGAGATGCCAG-1",
    "ATAACGCCAGGATCGA",
    "TTTGCGCTCATTCACT-1",
    "TTGGAACAGTGAACGC",
    "CTCTGGTAGATATGCA",
    "AGGTCCGTCGTCCGTT",
    "CGTAGCGTCACGAAGG",
    "CCGTACTTCGAATCCA",
    "CTTAACTGTCTACCTC",
    "AACACGTAGGAACTGC",
    "TACACGATCCATTCTA",
    "CAAGATCGTACGCACC-1",
    "CTCGAGGGTGCGATAG",
    "AAAGATGGTTGTCGCG-1",
    "CTCCTAGCACAGCGTC",
    "GATGCTAGTCATGCCG",
    "TCGCGAGGTGACAAAT",
    "CTACACCAGCGGCTTC",
    "GCATACAAGACCACGA",
    "CGCTATCCAAGCGAGT",
    "GACGGCTGTCTAGTGT",
    "GCATACATCGCCTGAG",
    "ACATGGTGTTCCACGG",
    "CGAGAAGCAAGCTGGA",
    "GGGACCTGTACCATCA",
    "TGGGAAGCAAACAACA",
    "CCACGGAAGAGACTAT",
    "ACGAGGACATGCTGGC",
    "GTGCTTCAGGTGGGTT",
    "TACAGTGGTAGGCATG",
    "TCGTAGATCCACTCCA",
    "TCAGCTCCACGTCTCT",
    "GCTCCTAGTCGCTTCT-1",
    "GCGAGAACAAATTGCC",
    "TTGAACGCAGGATTGG",
    "CGCCAAGCACGCCAGT",
    "CAGCTGGTCAGTTCGA",
    "GCCAAATAGTGCGTGA",
    "TGACAACTCGTCGTTC",
    "CAAGTTGTCGCCTGAG",
    "GGAATAATCGACCAGC",
    "TGTGTTTGTAGGAGTC",
    "ACGAGCCAGCTAGTTC",
    "ATGAGGGAGCCACCTG",
    "CACAGGCGTTGCCTCT",
    "GGAAAGCCACAGATTC",
    "CGATGGCTCAAAGTAG",
    "GTCTCGTAGCCAACAG",
    "AGCATACCACGTTGGC",
    "CACCACTCATCCAACA",
    "CAGCAGCCACTGTGTA",
    "CATTCGCCACGACTCG",
    "GATCGATTCGCGGATC",
    "GGGAGATAGACTTGAA",
    "GTAGTCACAGGCAGTA",
    "GACGGCTGTCCGAGTC",
    "CAGCTAAAGCTACCGC",
    "TGACAACGTCATACTG",
    "ACTTACTCACCCTATC-1",
    "TTTGCGCCAGCAGTTT",
    "CACAGTACATCCGGGT",
    "TGGCGCACATTTGCTT",
    "ATGCGATGTGTCAATC",
    "AGTGTCAAGATGAGAG",
    "GTATTCTTCAGGCAAG",
    "GTACTCCTCTGGTATG",
    "GGTATTGGTTGTCGCG",
    "CCTCAGTAGAGGTTAT",
    "ACACCAAGTACCCAAT",
    "TGGTTAGGTTGTTTGG",
    "CTTAACTCAATAGAGT",
    "ATTCTACTCAAGGCTT",
    "CGGACGTAGTCATGCT",
    "TCAATCTAGTATTGGA",
    "GGGCACTGTTACAGAA",
    "TTATGCTTCAGGCAAG"
  ],
  "guidance": {
    "steps": 0,
    "step_size": 0.5,
    "k_nearest": 10,
    "initialization": "best"
  },
  "summary": {
    "forward": {
      "mse_expression": {
        "mean": 0.05226644454523921,
        "lower": 0.01996123418211937,
        "upper": 0.11374979326501489,
        "n": 4
      },
      "effect_pearson": {
        "mean": 0.32413226179778576,
        "lower": 0.16285148449242115,
        "upper": 0.45276516675949097,
        "n": 4
      },
      "effect_pearson_de20": {
        "mean": 0.36883156280964613,
        "lower": 0.11915807519108057,
        "upper": 0.5761010944843292,
        "n": 4
      },
      "mmd2": {
        "mean": 0.32101945201829174,
        "lower": 0.1811731443065855,
        "upper": 0.5558868038445977,
        "n": 4
      },
      "sliced_wasserstein": {
        "mean": 0.6798534000985375,
        "lower": 0.47387842854261775,
        "upper": 1.023236421645777,
        "n": 4
      },
      "energy": {
        "mean": 2.070914464968992,
        "lower": 1.0828965018837335,
        "upper": 3.810186129544835,
        "n": 4
      },
      "variance_ratio": {
        "mean": 0.6377080231904984,
        "lower": 0.42682939767837524,
        "upper": 0.8629126846790314,
        "n": 4
      }
    },
    "inverse": {
      "exhaustive": {
        "top1": {
          "mean": 0.0,
          "lower": 0.0,
          "upper": 0.0,
          "n": 4
        },
        "top5": {
          "mean": 0.25,
          "lower": 0.0,
          "upper": 0.75,
          "n": 4
        },
        "ndcg10": {
          "mean": 0.2719784352113491,
          "lower": 0.08905179677700555,
          "upper": 0.3982649174710401,
          "n": 4
        },
        "measured_reward": {
          "mean": 0.20926370471715927,
          "lower": 0.029541105031967163,
          "upper": 0.39312974363565445,
          "n": 4
        },
        "measured_regret": {
          "mean": 0.37972987443208694,
          "lower": 0.28832583874464035,
          "upper": 0.49520108103752136,
          "n": 4
        },
        "selected_gene_overlap": {
          "mean": 0.0,
          "lower": 0.0,
          "upper": 0.0,
          "n": 4
        }
      }
    }
  },
  "forward": [
    {
      "target": "CEBPE_ZC3HAV1",
      "query_cells": 8,
      "genes_observed_in_training": false,
      "mse_expression": 0.024615293368697166,
      "effect_pearson": 0.32227033376693726,
      "effect_pearson_de20": 0.3534680902957916,
      "mmd2": 0.17735251725316292,
      "sliced_wasserstein": 0.4709217198512553,
      "energy": 1.0774736349434821,
      "variance_ratio": 0.5182489156723022
    },
    {
      "target": "CNN1",
      "query_cells": 8,
      "genes_observed_in_training": false,
      "mse_expression": 0.018507344648241997,
      "effect_pearson": 0.46030953526496887,
      "effect_pearson_de20": 0.5845378041267395,
      "mmd2": 0.18499377136000805,
      "sliced_wasserstein": 0.47683513723398013,
      "energy": 1.088319368823985,
      "variance_ratio": 0.9778006076812744
    },
    {
      "target": "HES7",
      "query_cells": 8,
      "genes_observed_in_training": false,
      "mse_expression": 0.14452801644802094,
      "effect_pearson": 0.06872837990522385,
      "effect_pearson_de20": -0.030344028025865555,
      "mmd2": 0.6795178146727942,
      "sliced_wasserstein": 1.205370183116376,
      "energy": 4.717475049785119,
      "variance_ratio": 0.33540987968444824
    },
    {
      "target": "PTPN12",
      "query_cells": 8,
      "genes_observed_in_training": true,
      "mse_expression": 0.021415123715996742,
      "effect_pearson": 0.44522079825401306,
      "effect_pearson_de20": 0.567664384841919,
      "mmd2": 0.24221370478720206,
      "sliced_wasserstein": 0.5662865601925385,
      "energy": 1.4003898063233815,
      "variance_ratio": 0.7193726897239685
    }
  ],
  "inverse": [
    {
      "target": "CEBPE_ZC3HAV1",
      "search": "exhaustive",
      "top1": 0.0,
      "top5": 0.0,
      "ndcg10": 0.3562071871080222,
      "rank": 6,
      "selected": "KLF1_MAP2K6",
      "predicted_reward": 3.1542032957077026e-05,
      "measured_reward": 0.2507260739803314,
      "measured_regret": 0.3648817837238312,
      "selected_gene_overlap": 0.0,
      "catalog_size": 20,
      "candidate_cell_evaluations": 160,
      "seconds": 0.001278222750443092,
      "top_score_ties": 1
    },
    {
      "target": "CNN1",
      "search": "exhaustive",
      "top1": 0.0,
      "top5": 0.0,
      "ndcg10": 0.3010299956639812,
      "rank": 9,
      "selected": "HES7",
      "predicted_reward": 0.009042967110872269,
      "measured_reward": -0.04418721795082092,
      "measured_regret": 0.5447869002819061,
      "selected_gene_overlap": 0.0,
      "catalog_size": 20,
      "candidate_cell_evaluations": 160,
      "seconds": 0.001278222750443092,
      "top_score_ties": 1
    },
    {
      "target": "HES7",
      "search": "exhaustive",
      "top1": 0.0,
      "top5": 1.0,
      "ndcg10": 0.43067655807339306,
      "rank": 4,
      "selected": "KLF1_MAP2K6",
      "predicted_reward": 0.022431805729866028,
      "measured_reward": 0.15951445698738098,
      "measured_regret": 0.34644362330436707,
      "selected_gene_overlap": 0.0,
      "catalog_size": 20,
      "candidate_cell_evaluations": 160,
      "seconds": 0.001278222750443092,
      "top_score_ties": 1
    },
    {
      "target": "PTPN12",
      "search": "exhaustive",
      "top1": 0.0,
      "top5": 0.0,
      "ndcg10": 0.0,
      "rank": 12,
      "selected": "KLF1_MAP2K6",
      "predicted_reward": -0.049349188804626465,
      "measured_reward": 0.4710015058517456,
      "measured_regret": 0.2628071904182434,
      "selected_gene_overlap": 0.0,
      "catalog_size": 20,
      "candidate_cell_evaluations": 160,
      "seconds": 0.001278222750443092,
      "top_score_ties": 1
    }
  ]
}