---
tags:
- enzyme
- protein
- pytorch
- biology
---

# AlphaEnzyme checkpoints

PyTorch checkpoints for the AlphaEnzyme specificity, kinetics, and mutation tasks. The corresponding code is available in the [AlphaEnzyme repository](https://github.com/GENTEL-Lab/AlphaEnzyme). Input data are published separately at [GENTEL-Lab/AlphaEnzyme-data](https://huggingface.co/datasets/GENTEL-Lab/AlphaEnzyme-data).

## Files

| Task | Checkpoint |
| --- | --- |
| Specificity | `checkpoints/specificity/specificity_final.pt` |
| Kinetics | `checkpoints/kinetics/seed_1234/multitask_epoch18.pt` |
| Kinetics | `checkpoints/kinetics/seed_2026/multitask_epoch2.pt` |
| Kinetics | `checkpoints/kinetics/seed_3407/multitask_epoch16.pt` |
| Mutation | `checkpoints/mutation_final.pt` |

Download all files into the AlphaEnzyme project root:

```bash
hf download GENTEL-Lab/AlphaEnzyme --local-dir .
```

This recreates the `checkpoints/` directory directly. To download a single checkpoint, provide its repository path to `hf download`.

`SHA256SUMS` records the SHA-256 digest of each released checkpoint. The checkpoints are provided as PyTorch `.pt` files; follow the repository's task-specific loading code and configuration when using them.