---
pretty_name: AlphaEnzyme data
tags:
- enzyme
- protein
- biology
---

# AlphaEnzyme data

Released input tables and supporting assets for the AlphaEnzyme specificity, kinetics, and mutation tasks. The corresponding code is available in the [`liuyong` branch of the AlphaEnzyme repository](https://github.com/yliust/AlphaEnzyme/tree/liuyong). Model checkpoints are published separately at [GENTEL-Lab/AlphaEnzyme](https://huggingface.co/GENTEL-Lab/AlphaEnzyme).

## Contents

- `inputs/specificity/`: training, validation, and evaluation tables; reference banks and reaction fingerprints.
- `inputs/kinetics/`: training, validation, and test tables; row-level auxiliary data, normalization statistics, and descriptor banks.
- `inputs/mutation/`: variant tables, fold definitions, fold row/index files, normalization files, and component inputs.
- `inputs/CONTRACT.json`: machine-readable file layout.
- `inputs/README.md`: detailed directory instructions.

Download into the AlphaEnzyme project root:

```bash
hf download GENTEL-Lab/AlphaEnzyme-data --type dataset --local-dir data
```

This recreates `data/inputs/`. Large per-pair Pairformer/ESMC feature caches are not included; see `docs/NEW_DATA.md` in the code repository for feature-generation commands. The repository contains task input files, not a single table directly loadable by the Hugging Face `datasets` library.

`SHA256SUMS` records the SHA-256 digest of each released file.