[ { "InterPro": [ { "InterPro-ID": "IPR008567", "InterPro-Name": "BKACE", "InterPro-Type": "FAMILY", "Beg": 6, "End": 303 }, { "InterPro-ID": "IPR013785", "InterPro-Name": "Aldolase_TIM", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1, "End": 310 }, { "InterPro-ID": "IPR008567", "InterPro-Name": "BKACE", "InterPro-Type": "FAMILY", "Beg": 6, "End": 302 } ], "response#1": "MATKRKVIITCAPTGAIHTPSMSPYLPVTPQQIGDAALAAAKEGAAIIHLHARDPDDGHPTQDPAVFQEFLPRIKAECDAVINLTTGGSPHMTVAERLKPAHHFQPEVASLNMGSMNFGLYPMLERFKELKYDWERKHLENSRDLVFKNTFADIEYILTSCGANGTRFEFECYDISHLYNLAHFVDRGLAKPPFFVQSVFGLLGGIGAHPEDLAHMRRTADRLFGKDYVWSILGAGRNQIPLASIGVAQGSNARVGLEDSLWIEPGKLAESSAAQVRKIRQVIEGLSLDIATPAEAREMLQLKGAANTNF", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to BKACE, BKACE that shares evolutionary origin and functional similarity; 2. The protein should be classified within Aldolase_TIM sharing conserved structural features. The designed protein sequence is ", "reference": "MATKRKVIITCAPTGAIHTPSMSPYLPVTPQQIGDAALAAAKEGAAIIHLHARDPDDGHPTQDPAVFQEFLPRIKAECDAVINLTTGGSPHMTVAERLKPAHHFQPEVASLNMGSMNFGLYPMLERFKELKYDWERKHLENSRDLVFKNTFADIEYILTSCGANGTRFEFECYDISHLYNLAHFVDRGLAKPPFFVQSVFGLLGGIGAHPEDLAHMRRTADRLFGKDYVWSILGAGRNQIPLASIGVAQGSNARVGLEDSLWIEPGKLAESSAAQVRKIRQVIEGLSLDIATPAEAREMLQLKGAANTNF" }, { "InterPro": [ { "InterPro-ID": "IPR017896", "InterPro-Name": "4Fe4S_Fe-S-bd", "InterPro-Type": "DOMAIN", "Beg": 9, "End": 40 }, { "InterPro-ID": "IPR017896", "InterPro-Name": "4Fe4S_Fe-S-bd", "InterPro-Type": "DOMAIN", "Beg": 48, "End": 80 }, { "InterPro-ID": "IPR017900", "InterPro-Name": "4Fe4S_Fe_S_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 91, "End": 102 }, { "InterPro-ID": "IPR017896", "InterPro-Name": "4Fe4S_Fe-S-bd", "InterPro-Type": "DOMAIN", "Beg": 54, "End": 132 }, { "InterPro-ID": "IPR017896", "InterPro-Name": "4Fe4S_Fe-S-bd", "InterPro-Type": "DOMAIN", "Beg": 82, "End": 111 }, { "InterPro-ID": "IPR017896", "InterPro-Name": "4Fe4S_Fe-S-bd", "InterPro-Type": "DOMAIN", "Beg": 15, "End": 28 }, { "InterPro-ID": "IPR050294", "InterPro-Name": "RnfB_subfamily", "InterPro-Type": "FAMILY", "Beg": 3, "End": 134 } ], "response#1": "MSEEVQERIWILITPDKCSGCRLCEVTCSLEHEGIIWPEASRIRVFELFPGINVPHTCVQCPDYPCVNACPTNALSVDEKTGAVVVNEEKCITCGACVLACPGKVPRIPAGKGSVVICDLCGGNPKCVEICHEAGHDALKIVTGNYRPIYRTFAKDPQEKSLDIARKVFGEDF", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more 4Fe4S_Fe-S-bd, 4Fe4S_Fe-S-bd, 4Fe4S_Fe-S-bd, 4Fe4S_Fe-S-bd, 4Fe4S_Fe-S-bd that are essential for its biological function; 2. The protein should belong to RnfB_subfamily that shares evolutionary origin and functional similarity; 3. The protein should contain 4Fe4S_Fe_S_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MSEEVQERIWILITPDKCSGCRLCEVTCSLEHEGIIWPEASRIRVFELFPGINVPHTCVQCPDYPCVNACPTNALSVDEKTGAVVVNEEKCITCGACVLACPGKVPRIPAGKGSVVICDLCGGNPKCVEICHEAGHDALKIVTGNYRPIYRTFAKDPQEKSLDIARKVFGEDF" }, { "InterPro": [ { "InterPro-ID": "IPR003439", "InterPro-Name": "ABC_transporter-like_ATP-bd", "InterPro-Type": "DOMAIN", "Beg": 705, "End": 936 }, { "InterPro-ID": "IPR000953", "InterPro-Name": "Chromo/chromo_shadow_dom", "InterPro-Type": "DOMAIN", "Beg": 816, "End": 872 }, { "InterPro-ID": "IPR050611", "InterPro-Name": "ABCF_EF3_subfamily", "InterPro-Type": "FAMILY", "Beg": 664, "End": 984 }, { "InterPro-ID": "IPR003439", "InterPro-Name": "ABC_transporter-like_ATP-bd", "InterPro-Type": "DOMAIN", "Beg": 462, "End": 590 }, { "InterPro-ID": "IPR011989", "InterPro-Name": "ARM-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 18, "End": 338 }, { "InterPro-ID": "IPR003439", "InterPro-Name": "ABC_transporter-like_ATP-bd", "InterPro-Type": "DOMAIN", "Beg": 447, "End": 659 }, { "InterPro-ID": "IPR003439", "InterPro-Name": "ABC_transporter-like_ATP-bd", "InterPro-Type": "DOMAIN", "Beg": 687, "End": 1004 }, { "InterPro-ID": "IPR003593", "InterPro-Name": "AAA+_ATPase", "InterPro-Type": "DOMAIN", "Beg": 471, "End": 636 }, { "InterPro-ID": "IPR003593", "InterPro-Name": "AAA+_ATPase", "InterPro-Type": "DOMAIN", "Beg": 713, "End": 986 }, { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 446, "End": 643 }, { "InterPro-ID": "IPR017871", "InterPro-Name": "ABC_transporter-like_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 908, "End": 922 }, { "InterPro-ID": "IPR047038", "InterPro-Name": "eEF3_chromodomain-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 783, "End": 882 }, { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 437, "End": 655 }, { "InterPro-ID": "IPR021133", "InterPro-Name": "HEAT_type_2", "InterPro-Type": "REPEAT", "Beg": 181, "End": 219 }, { "InterPro-ID": "IPR016024", "InterPro-Name": "ARM-type_fold", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 28, "End": 1050 }, { "InterPro-ID": "IPR015688", "InterPro-Name": "eEF3_ABC2_chromodomain-like", "InterPro-Type": "DOMAIN", "Beg": 817, "End": 872 }, { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 664, "End": 980 }, { "InterPro-ID": "IPR034085", "InterPro-Name": "TOG", "InterPro-Type": "DOMAIN", "Beg": 3, "End": 240 }, { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 683, "End": 987 }, { "InterPro-ID": "IPR017871", "InterPro-Name": "ABC_transporter-like_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 562, "End": 576 } ], "response#1": "MAPAATAAASSGKGSFDLATLFVADKAARDEAGLALADAVKKSGVEFFTQIGFNDAIVKALNDKKSQSAREGACEVISTLCENGAAQLLEPHVISSAENTPFPALLEAFADKVAAVKTAAIAAVKAIVQSMNPWASFVLLPALLNLIRTSGKWQIKAGSLEILQQLITSAPYQMGEAMPDLVPVLAGAVWDTKSDVKKAAKATLEKAVSLVENKDIEKFVPALVKSLLNPIEEVPKTISLLSATTFVSEVTAPTISLIAPLLIRGLDERPTATKRKVCVIADNMSKLVDSEYTVRPFLPQLLPRLIKTAETIADPEARSVANRAIVTLRRIGKVPVESDGSDLPPLPVAEGPHLATNFVALVKKHGGVSVEQTNPGLAYAGVLAASLVNHHNFDQKTWESTLPPYLKLALPSYDSLPAVRELLQKKADEAETDDAKFPDEEEGEDLCNIEQFNLAYGAKILLHHANMRLKRGHRYGLCGRNGSGKSTLMNAIINNQVEGFPPPTEVRTFYVQHDIDGSEAEISILDWVLSDKRLLATPEEIKSTLESVGFDEVKQKNSIGSLSGGWKMKLALARAILFKADILLLDEPTNHLDVLNVDWLINYLTSLTRCTSIIVSHDSDFLNRTVTDVLHLNNFKLKRYPGNLEEFVKHVPEAKSYYQLDVAEDYQFKLPNPPLLDGVKTKEKSLLKMRNVSFQYPGSSIQQLYDISLQVSLSSRVAVLGPNGSGKSTLVKLLTGETEPNLGGQVWKHPNLVIGYVAQHAFHHIDNHLDSTPLEYMLWRYQTGEDLEEMHKANRVMTEAELAKMKEGATVIKDGVKRIIDELVARKKLKQSYEYEVSFKGMSSAENIWISRDELVARGFEKKVMELDTREAQRLGLMRPLVRREIEKHFEDFGLDAEFVSHNSMRGLSGGQKVKVVLGAATWRRPHIICLDEPTNYLDRESLAALIAALKNFEGGVLIITHNREFSESICTEVWAMREGHLEASGHNWVEGQGSGERIDKKAGDDDEVEYDALGNPIVKAKKEKKLSAADKRKAKKDRMARRKRGEEVFSDEEL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more ABC_transporter-like_ATP-bd, Chromo/chromo_shadow_dom, ABC_transporter-like_ATP-bd, ABC_transporter-like_ATP-bd, ABC_transporter-like_ATP-bd, AAA+_ATPase, AAA+_ATPase, eEF3_ABC2_chromodomain-like, TOG that are essential for its biological function; 2. The protein should belong to ABCF_EF3_subfamily that shares evolutionary origin and functional similarity; 3. The protein should be classified within ARM-like, P-loop_NTPase, eEF3_chromodomain-like_sf, P-loop_NTPase, ARM-type_fold, P-loop_NTPase, P-loop_NTPase sharing conserved structural features; 4. The protein should include one or more HEAT_type_2 that provide structural or functional support; 5. The protein should contain ABC_transporter-like_CS, ABC_transporter-like_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MAPAATAAASSGKGSFDLATLFVADKAARDEAGLALADAVKKSGVEFFTQIGFNDAIVKALNDKKSQSAREGACEVISTLCENGAAQLLEPHVISSAENTPFPALLEAFADKVAAVKTAAIAAVKAIVQSMNPWASFVLLPALLNLIRTSGKWQIKAGSLEILQQLITSAPYQMGEAMPDLVPVLAGAVWDTKSDVKKAAKATLEKAVSLVENKDIEKFVPALVKSLLNPIEEVPKTISLLSATTFVSEVTAPTISLIAPLLIRGLDERPTATKRKVCVIADNMSKLVDSEYTVRPFLPQLLPRLIKTAETIADPEARSVANRAIVTLRRIGKVPVESDGSDLPPLPVAEGPHLATNFVALVKKHGGVSVEQTNPGLAYAGVLAASLVNHHNFDQKTWESTLPPYLKLALPSYDSLPAVRELLQKKADEAETDDAKFPDEEEGEDLCNIEQFNLAYGAKILLHHANMRLKRGHRYGLCGRNGSGKSTLMNAIINNQVEGFPPPTEVRTFYVQHDIDGSEAEISILDWVLSDKRLLATPEEIKSTLESVGFDEVKQKNSIGSLSGGWKMKLALARAILFKADILLLDEPTNHLDVLNVDWLINYLTSLTRCTSIIVSHDSDFLNRTVTDVLHLNNFKLKRYPGNLEEFVKHVPEAKSYYQLDVAEDYQFKLPNPPLLDGVKTKEKSLLKMRNVSFQYPGSSIQQLYDISLQVSLSSRVAVLGPNGSGKSTLVKLLTGETEPNLGGQVWKHPNLVIGYVAQHAFHHIDNHLDSTPLEYMLWRYQTGEDLEEMHKANRVMTEAELAKMKEGATVIKDGVKRIIDELVARKKLKQSYEYEVSFKGMSSAENIWISRDELVARGFEKKVMELDTREAQRLGLMRPLVRREIEKHFEDFGLDAEFVSHNSMRGLSGGQKVKVVLGAATWRRPHIICLDEPTNYLDRESLAALIAALKNFEGGVLIITHNREFSESICTEVWAMREGHLEASGHNWVEGQGSGERIDKKAGDDDEVEYDALGNPIVKAKKEKKLSAADKRKAKKDRMARRKRGEEVFSDEEL" }, { "InterPro": [ { "InterPro-ID": "IPR038788", "InterPro-Name": "TEX46-like", "InterPro-Type": "FAMILY", "Beg": 1, "End": 161 }, { "InterPro-ID": "IPR038788", "InterPro-Name": "TEX46-like", "InterPro-Type": "FAMILY", "Beg": 11, "End": 161 } ], "response#1": "MLGELIFLLRSLHGFLASSGPIGAALAWLISFKPILFAFLLLLLLLSNWLVKQEHNLAPSPPQEEAETTTAPEVHPKNNVKNKEELEKINACFALQDKVLERLMFSEMKLKALENQVFVIWNKINRRRWSSRQRNFSRRRHRSRRHDSTFSTLSKCTTVTPTECD", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to TEX46-like, TEX46-like that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MLGELIFLLRSLHGFLASSGPIGAALAWLISFKPILFAFLLLLLLLSNWLVKQEHNLAPSPPQEEAETTTAPEVHPKNNVKNKEELEKINACFALQDKVLERLMFSEMKLKALENQVFVIWNKINRRRWSSRQRNFSRRRHRSRRHDSTFSTLSKCTTVTPTECD" }, { "InterPro": [ { "InterPro-ID": "IPR050570", "InterPro-Name": "Cell_wall_metabolism_enzyme", "InterPro-Type": "FAMILY", "Beg": 19, "End": 390 }, { "InterPro-ID": "IPR054512", "InterPro-Name": "NMB0315-like_N", "InterPro-Type": "DOMAIN", "Beg": 61, "End": 143 }, { "InterPro-ID": "IPR011055", "InterPro-Name": "Dup_hybrid_motif", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 140, "End": 388 }, { "InterPro-ID": "IPR016047", "InterPro-Name": "Peptidase_M23", "InterPro-Type": "DOMAIN", "Beg": 294, "End": 387 }, { "InterPro-ID": "IPR011055", "InterPro-Name": "Dup_hybrid_motif", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 268, "End": 393 } ], "response#1": "MAVFPLSAKHRKYALRALAVSIILVSAAYIASTERTERVRPQRVEQNLPPLSWGGSGVQTAYWVQEAVQPGDSLADVLARSGMARDEIARITEKYGGEADLRHLRADQSVHVLVGGDGGAREVQFFTDEDGERNLVALEKKGGIWRRSASEADMKVLPTLRSVVVKTSARGSLARAEVPVEIRESLSGIFAGRFSLDGLKEGDAVRLMYDSLYFHGQQVAAGDILAAEVVKGGTRHQAFYYRSDKEGGGGGNYYDEDGKVLQEKGGFNIEPLVYTRISSPFGYRMHPILHTWRLHTGIDYAAPQGTPVRASADGVITFKGRKGGYGNAVMIRHANGVETLYAHLSAFSQAEGNVRGGEVIGFVGSTGRSTGPHLHYEARINGQPVNPVSVALPTPELTQADKAAFAAQKQKADALLARLRGIPVTVSQSD", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more NMB0315-like_N, Peptidase_M23 that are essential for its biological function; 2. The protein should belong to Cell_wall_metabolism_enzyme that shares evolutionary origin and functional similarity; 3. The protein should be classified within Dup_hybrid_motif, Dup_hybrid_motif sharing conserved structural features. The designed protein sequence is ", "reference": "MAVFPLSAKHRKYALRALAVSIILVSAAYIASTERTERVRPQRVEQNLPPLSWGGSGVQTAYWVQEAVQPGDSLADVLARSGMARDEIARITEKYGGEADLRHLRADQSVHVLVGGDGGAREVQFFTDEDGERNLVALEKKGGIWRRSASEADMKVLPTLRSVVVKTSARGSLARAEVPVEIRESLSGIFAGRFSLDGLKEGDAVRLMYDSLYFHGQQVAAGDILAAEVVKGGTRHQAFYYRSDKEGGGGGNYYDEDGKVLQEKGGFNIEPLVYTRISSPFGYRMHPILHTWRLHTGIDYAAPQGTPVRASADGVITFKGRKGGYGNAVMIRHANGVETLYAHLSAFSQAEGNVRGGEVIGFVGSTGRSTGPHLHYEARINGQPVNPVSVALPTPELTQADKAAFAAQKQKADALLARLRGIPVTVSQSD" }, { "InterPro": [ { "InterPro-ID": "IPR000884", "InterPro-Name": "TSP1_rpt", "InterPro-Type": "REPEAT", "Beg": 2076, "End": 2131 }, { "InterPro-ID": "IPR000884", "InterPro-Name": "TSP1_rpt", "InterPro-Type": "REPEAT", "Beg": 1758, "End": 1811 }, { "InterPro-ID": "IPR000884", "InterPro-Name": "TSP1_rpt", "InterPro-Type": "REPEAT", "Beg": 2487, "End": 2549 }, { "InterPro-ID": "IPR000884", "InterPro-Name": "TSP1_rpt", "InterPro-Type": "REPEAT", "Beg": 2484, "End": 2549 }, { "InterPro-ID": "IPR037221", "InterPro-Name": "H-type_lectin_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1143, "End": 1235 }, { "InterPro-ID": "IPR037221", "InterPro-Name": "H-type_lectin_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1151, "End": 1236 }, { "InterPro-ID": "IPR000884", "InterPro-Name": "TSP1_rpt", "InterPro-Type": "REPEAT", "Beg": 1755, "End": 1811 } ], "response#1": "MVFRATREPFRLPLVAAFIALFLLKGVTCQLQLGTSTLQKNMWTTVKFDEPMIDPVVFVSPPEAPTNSFALVLIGGVTTSGFRARVYFPSCEYSPSGGTLYAVRWLAVEATSAGYYDSSNRQTIDWTAHAVTLASSGTIPAGYVWSQSFSAWEDRPGTPGVLIGVQNHREMISAMYWSSEYLNPLVINSNSGGTLTFSFLRQISHRIGFTLKVGIFQYDARRGAVINGVNLVAQRYDLKVNEVLPVADVVAGGTTPATFAVQWVTPTEAPLALVVKPKLLPDGSYSESLVAVEDCRNGATYEPHAFDVTHAFTGNPASTAHRINGGPNCFRPSASVPTWLTEPCKLACESLWTANSDDYWNCDDVNACFETDFRSAETLMALPQIDESIADVLVTSCNFATRTADLIKQYEYAVNLKVDDIAIGTMWSTSSHCGGDKMEVEIVGAFYEKLGVSILTGSTCEVQDVSREVEALCKAEGGIGCSISAAQIYELIMNYPGVCFALEDAELQIFFNCTFASTSPFDCELYESKGFDQENGDCMCPNALAACTREEATFKSGWLQNLNKSYQYMLHGQIRYVAKSSVFQAFYEAPETSSAGDNTLCARMNTIVVCKNPTPVSAVVGNRGPNCYVIEHGSQYCHLPCLTAWDAFLAAKDLPQQSDYQAEFERFWLSFDFPAIPPHTSQSLLEQLQRCRFATRPATAPLQQYEDEIDVQLPDYGAVIIPLGCDKLHHREVVQALVGSASSIMLGVHEPGCRYEDATETVQRECKAAVSARKTTCEIDSSLFTSKDILCNTSTIKLIIRGTCIPGPYLPTNYTCALYPTTGVVSRDGRSCTCPNSAYPCTYEEGQLTASRWKNEVNTGATVSLANNVVWTAPPGTSEYTYTHTDAYDYVCSTDEHHFVLCKDLTPSALPLTEREPHCLNSFSVKPDASTVDDRDCQDQCASLFATRCRQSFYKWLCVAQGLPECYIPNTDSFTCQIDTNPSAYNYSYGSCGCSGAYPPCSRNEANATRLDWITAFRALSHKKGVVVARGKQALWTENPDRWRYENGMLQGGGCLNNSWFVGVFCGAHLSVTPPARGDVLPLCSSAAKVENPDTPYPACRVLCAQVLNECKKVFSTTEGAAAYASVFDCFKARGKGTTLDNCTYELGPENRATGVAELHTGWTVASASWSRVLFDVEFADPPVVFLGIPKDTQPFYTPSVRLVTKTSFEVKLYRNNCGLDDTRSSSAPVSWMAIPEGAYLTDFVENPVRVMKLPMTTRTPTVLTFSLSGLKEPEEMVALAQVQDVTPTSVSTDRVAVVISNLKTNSLELSLVVDESVNFSTVAVGILISGKQNPDLAAGLSPLLNRYHLQTFRIPAAAYSATSILGEGLYLSGGIMPHVFAAAIQTRSMTKELNESDRVVISRRATTTPFTWSALLWKKTCEAKHMFEAVENPSDLIIAGIYVEARKDEPSAILGNRHDLCLSFIGQSFESGVVATCMGACRSALPASVQLHCQDECALNIFAPSVHTKCMTDCESLLVAQYEECAGQCTATGTASCQRKCKQFLGNKCDSTASSDVAACLEFVTPPSVFEQCTLLVEYSVSEGGPSDGFEIEEETTPSQTYENCIIVDMRDERFTAFTGWDSRVASCKCPNDFRACTSETVNTQNHWRTELLASAGLCKEQPDGRFNAVTQQLWSTTGDLCALAADEQQPPISWASNMLPAYVDQDIVLDNSTIRSGDYQCREIWHYVVCPAAATSTTTQEPPVPPFTATLNTAIVGEWGEWSACTGTCFSQWWTPKRTRTRLVLAELSHSQIPSVSETATCLDLPPCGTVCWEREWTEWSECKLFTIVMGQGLEYFRQQIKPVFDFVEEACGLDEHERYERCGEEQDNGETPATSTLQTDSLLETRSLTVSHGTAARALPRVSMDPALERPSFASLHGTRSHVPASTDAKIIERRKGIMSRRRSVPPSGYLEETAEQVAHGGESEQSGKASQNGSRRHRASRKQKRDLESIYSDASVRGSGESTLHGTGTNAYRDQIEWTSKSSSRSAIRDSGARGAEAGTSLLQKARRARRGAGRFRKSRSQARNQTPDKSCSVVSEWSGCDSPCLPHKGSTPRRYRLAVPGQNEANYCTVPLSGTEHLCTDLPQCAHPNFDCAKVTASRLTDEDIAACKAVCVEVVKTCETMMSAVFSLYTSLEQCALVQFQEYEQFPGQCHIPEEYTSTRRPTKCFPSRTRRRVASGELPFIFQVSTASGTSPSATSDAASSVAESFVSTGTASAPSSRVMNALAFEASASQTSIDSCECYDPADEPCTAQEARDSLFDSLYLFLTHPLCAESPAAEGALFTMSEPNQTADAASYFALRGLGRMHCPVPMYKSSTEVKGVLTPKRVTFSEFKTKEDLNEFCHKGLSNWRQNVPPEIIGSASFPNCMLVTPREGAEPQDCALLCSETMSSCSAASLSFVELSQCVQDKLTESDFYSKCSAPEVLAPGEGIILCKKKVSTCDYTEWSEWSTCTATCFNWDEGVIPLRVRSRDFASSSADSRVLCRLESQNDAIQTEKCDWMPVCPEAEGEEEDDATGGVEPRGEPIVPPWSPERPTDENNQAMGSEDIVSGTVECYVTNMGTIMTSYYRGYNQEYHGCNCPGGRRPCTRAEAVASLDLWTKDSGGLCDQDMATMISAAEGEAFFCATGSFGKIDTSLSESSCASSEYQYVLCEGHPYEGIANLTTWVICLLLGVGGGICFVLSCVQYSSDIQKLLGLAGSYPVLVQNVTELQERESHKLRRQGNISATSERSDAHALSLSDSGWDVDGNQSAGSAFPEEEPWQFEDRDEEPLLSTRKYSRNLGSAGIPEPSEIGQTSPTQQRVPRASLAAQRSTCQLSSRLGQANSPEQSLERRSLKLRDSHADVELQRTLRKEMKGNQVWDKTV", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should be classified within H-type_lectin_dom_sf, H-type_lectin_dom_sf sharing conserved structural features; 2. The protein should include one or more TSP1_rpt, TSP1_rpt, TSP1_rpt, TSP1_rpt, TSP1_rpt that provide structural or functional support. The designed protein sequence is ", "reference": "MVFRATREPFRLPLVAAFIALFLLKGVTCQLQLGTSTLQKNMWTTVKFDEPMIDPVVFVSPPEAPTNSFALVLIGGVTTSGFRARVYFPSCEYSPSGGTLYAVRWLAVEATSAGYYDSSNRQTIDWTAHAVTLASSGTIPAGYVWSQSFSAWEDRPGTPGVLIGVQNHREMISAMYWSSEYLNPLVINSNSGGTLTFSFLRQISHRIGFTLKVGIFQYDARRGAVINGVNLVAQRYDLKVNEVLPVADVVAGGTTPATFAVQWVTPTEAPLALVVKPKLLPDGSYSESLVAVEDCRNGATYEPHAFDVTHAFTGNPASTAHRINGGPNCFRPSASVPTWLTEPCKLACESLWTANSDDYWNCDDVNACFETDFRSAETLMALPQIDESIADVLVTSCNFATRTADLIKQYEYAVNLKVDDIAIGTMWSTSSHCGGDKMEVEIVGAFYEKLGVSILTGSTCEVQDVSREVEALCKAEGGIGCSISAAQIYELIMNYPGVCFALEDAELQIFFNCTFASTSPFDCELYESKGFDQENGDCMCPNALAACTREEATFKSGWLQNLNKSYQYMLHGQIRYVAKSSVFQAFYEAPETSSAGDNTLCARMNTIVVCKNPTPVSAVVGNRGPNCYVIEHGSQYCHLPCLTAWDAFLAAKDLPQQSDYQAEFERFWLSFDFPAIPPHTSQSLLEQLQRCRFATRPATAPLQQYEDEIDVQLPDYGAVIIPLGCDKLHHREVVQALVGSASSIMLGVHEPGCRYEDATETVQRECKAAVSARKTTCEIDSSLFTSKDILCNTSTIKLIIRGTCIPGPYLPTNYTCALYPTTGVVSRDGRSCTCPNSAYPCTYEEGQLTASRWKNEVNTGATVSLANNVVWTAPPGTSEYTYTHTDAYDYVCSTDEHHFVLCKDLTPSALPLTEREPHCLNSFSVKPDASTVDDRDCQDQCASLFATRCRQSFYKWLCVAQGLPECYIPNTDSFTCQIDTNPSAYNYSYGSCGCSGAYPPCSRNEANATRLDWITAFRALSHKKGVVVARGKQALWTENPDRWRYENGMLQGGGCLNNSWFVGVFCGAHLSVTPPARGDVLPLCSSAAKVENPDTPYPACRVLCAQVLNECKKVFSTTEGAAAYASVFDCFKARGKGTTLDNCTYELGPENRATGVAELHTGWTVASASWSRVLFDVEFADPPVVFLGIPKDTQPFYTPSVRLVTKTSFEVKLYRNNCGLDDTRSSSAPVSWMAIPEGAYLTDFVENPVRVMKLPMTTRTPTVLTFSLSGLKEPEEMVALAQVQDVTPTSVSTDRVAVVISNLKTNSLELSLVVDESVNFSTVAVGILISGKQNPDLAAGLSPLLNRYHLQTFRIPAAAYSATSILGEGLYLSGGIMPHVFAAAIQTRSMTKELNESDRVVISRRATTTPFTWSALLWKKTCEAKHMFEAVENPSDLIIAGIYVEARKDEPSAILGNRHDLCLSFIGQSFESGVVATCMGACRSALPASVQLHCQDECALNIFAPSVHTKCMTDCESLLVAQYEECAGQCTATGTASCQRKCKQFLGNKCDSTASSDVAACLEFVTPPSVFEQCTLLVEYSVSEGGPSDGFEIEEETTPSQTYENCIIVDMRDERFTAFTGWDSRVASCKCPNDFRACTSETVNTQNHWRTELLASAGLCKEQPDGRFNAVTQQLWSTTGDLCALAADEQQPPISWASNMLPAYVDQDIVLDNSTIRSGDYQCREIWHYVVCPAAATSTTTQEPPVPPFTATLNTAIVGEWGEWSACTGTCFSQWWTPKRTRTRLVLAELSHSQIPSVSETATCLDLPPCGTVCWEREWTEWSECKLFTIVMGQGLEYFRQQIKPVFDFVEEACGLDEHERYERCGEEQDNGETPATSTLQTDSLLETRSLTVSHGTAARALPRVSMDPALERPSFASLHGTRSHVPASTDAKIIERRKGIMSRRRSVPPSGYLEETAEQVAHGGESEQSGKASQNGSRRHRASRKQKRDLESIYSDASVRGSGESTLHGTGTNAYRDQIEWTSKSSSRSAIRDSGARGAEAGTSLLQKARRARRGAGRFRKSRSQARNQTPDKSCSVVSEWSGCDSPCLPHKGSTPRRYRLAVPGQNEANYCTVPLSGTEHLCTDLPQCAHPNFDCAKVTASRLTDEDIAACKAVCVEVVKTCETMMSAVFSLYTSLEQCALVQFQEYEQFPGQCHIPEEYTSTRRPTKCFPSRTRRRVASGELPFIFQVSTASGTSPSATSDAASSVAESFVSTGTASAPSSRVMNALAFEASASQTSIDSCECYDPADEPCTAQEARDSLFDSLYLFLTHPLCAESPAAEGALFTMSEPNQTADAASYFALRGLGRMHCPVPMYKSSTEVKGVLTPKRVTFSEFKTKEDLNEFCHKGLSNWRQNVPPEIIGSASFPNCMLVTPREGAEPQDCALLCSETMSSCSAASLSFVELSQCVQDKLTESDFYSKCSAPEVLAPGEGIILCKKKVSTCDYTEWSEWSTCTATCFNWDEGVIPLRVRSRDFASSSADSRVLCRLESQNDAIQTEKCDWMPVCPEAEGEEEDDATGGVEPRGEPIVPPWSPERPTDENNQAMGSEDIVSGTVECYVTNMGTIMTSYYRGYNQEYHGCNCPGGRRPCTRAEAVASLDLWTKDSGGLCDQDMATMISAAEGEAFFCATGSFGKIDTSLSESSCASSEYQYVLCEGHPYEGIANLTTWVICLLLGVGGGICFVLSCVQYSSDIQKLLGLAGSYPVLVQNVTELQERESHKLRRQGNISATSERSDAHALSLSDSGWDVDGNQSAGSAFPEEEPWQFEDRDEEPLLSTRKYSRNLGSAGIPEPSEIGQTSPTQQRVPRASLAAQRSTCQLSSRLGQANSPEQSLERRSLKLRDSHADVELQRTLRKEMKGNQVWDKTV" }, { "InterPro": [ { "InterPro-ID": "IPR000485", "InterPro-Name": "AsnC-type_HTH_dom", "InterPro-Type": "DOMAIN", "Beg": 20, "End": 31 }, { "InterPro-ID": "IPR000485", "InterPro-Name": "AsnC-type_HTH_dom", "InterPro-Type": "DOMAIN", "Beg": 4, "End": 20 }, { "InterPro-ID": "IPR000485", "InterPro-Name": "AsnC-type_HTH_dom", "InterPro-Type": "DOMAIN", "Beg": 31, "End": 50 }, { "InterPro-ID": "IPR019888", "InterPro-Name": "Tscrpt_reg_AsnC-like", "InterPro-Type": "FAMILY", "Beg": 4, "End": 111 }, { "InterPro-ID": "IPR000485", "InterPro-Name": "AsnC-type_HTH_dom", "InterPro-Type": "DOMAIN", "Beg": 4, "End": 65 }, { "InterPro-ID": "IPR011008", "InterPro-Name": "Dimeric_a/b-barrel", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 64, "End": 146 }, { "InterPro-ID": "IPR036390", "InterPro-Name": "WH_DNA-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 3, "End": 64 }, { "InterPro-ID": "IPR000485", "InterPro-Name": "AsnC-type_HTH_dom", "InterPro-Type": "DOMAIN", "Beg": 4, "End": 44 }, { "InterPro-ID": "IPR019887", "InterPro-Name": "Tscrpt_reg_AsnC/Lrp_C", "InterPro-Type": "DOMAIN", "Beg": 70, "End": 140 }, { "InterPro-ID": "IPR036388", "InterPro-Name": "WH-like_DNA-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1, "End": 57 } ], "response#1": "MDRLDDTDERILAELAEHARATFAEIGHKVSLSAPAVKRRVDRMLESGVIKGFTTVVDRNALGWNTEAYVQIFCHGRIAPDQLRAAWVNIPEVVSAATVTGTSDAILHVLAHDMRHLEAALERIRSSADVERSESTVVLSNLIDRMPP", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more AsnC-type_HTH_dom, AsnC-type_HTH_dom, AsnC-type_HTH_dom, AsnC-type_HTH_dom, AsnC-type_HTH_dom, Tscrpt_reg_AsnC/Lrp_C that are essential for its biological function; 2. The protein should belong to Tscrpt_reg_AsnC-like that shares evolutionary origin and functional similarity; 3. The protein should be classified within Dimeric_a/b-barrel, WH_DNA-bd_sf, WH-like_DNA-bd_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MDRLDDTDERILAELAEHARATFAEIGHKVSLSAPAVKRRVDRMLESGVIKGFTTVVDRNALGWNTEAYVQIFCHGRIAPDQLRAAWVNIPEVVSAATVTGTSDAILHVLAHDMRHLEAALERIRSSADVERSESTVVLSNLIDRMPP" }, { "InterPro": [ { "InterPro-ID": "IPR033113", "InterPro-Name": "PLipase_A2_His_AS", "InterPro-Type": "ACTIVE_SITE", "Beg": 69, "End": 76 }, { "InterPro-ID": "IPR016090", "InterPro-Name": "PLipase_A2_dom", "InterPro-Type": "DOMAIN", "Beg": 42, "End": 136 }, { "InterPro-ID": "IPR036444", "InterPro-Name": "PLipase_A2_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 40, "End": 171 }, { "InterPro-ID": "IPR016090", "InterPro-Name": "PLipase_A2_dom", "InterPro-Type": "DOMAIN", "Beg": 38, "End": 154 }, { "InterPro-ID": "IPR036444", "InterPro-Name": "PLipase_A2_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 41, "End": 167 } ], "response#1": "MHALRSSVLALWLCLHVSVRAWMTYRSANGLDEYEPEDRIIFLGTKWCGNGNVAEGPEDLGPLKETDACCREHDMCPDLIAAGQSKHGLTNTASYTRLNCGCDEKFYNCLKNSAETGSGAVRFTYFTVLGTKCYRNEHPLICVKKGWFSCSKYELDKSQPKRYQWFDVSSNFAFPRMLT", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more PLipase_A2_dom, PLipase_A2_dom that are essential for its biological function; 2. The protein should be classified within PLipase_A2_dom_sf, PLipase_A2_dom_sf sharing conserved structural features; 3. The protein must have PLipase_A2_His_AS that is conserved among related catalytic enzymes. The designed protein sequence is ", "reference": "MHALRSSVLALWLCLHVSVRAWMTYRSANGLDEYEPEDRIIFLGTKWCGNGNVAEGPEDLGPLKETDACCREHDMCPDLIAAGQSKHGLTNTASYTRLNCGCDEKFYNCLKNSAETGSGAVRFTYFTVLGTKCYRNEHPLICVKKGWFSCSKYELDKSQPKRYQWFDVSSNFAFPRMLT" }, { "InterPro": [ { "InterPro-ID": "IPR016181", "InterPro-Name": "Acyl_CoA_acyltransferase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 26, "End": 151 }, { "InterPro-ID": "IPR000182", "InterPro-Name": "GNAT_dom", "InterPro-Type": "DOMAIN", "Beg": 85, "End": 143 } ], "response#1": "MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDPIPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLVESV", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more GNAT_dom that are essential for its biological function; 2. The protein should be classified within Acyl_CoA_acyltransferase sharing conserved structural features. The designed protein sequence is ", "reference": "MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDPIPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLVESV" }, { "InterPro": [ { "InterPro-ID": "IPR050763", "InterPro-Name": "ABC_transporter_ATP-binding", "InterPro-Type": "FAMILY", "Beg": 4, "End": 310 }, { "InterPro-ID": "IPR003439", "InterPro-Name": "ABC_transporter-like_ATP-bd", "InterPro-Type": "DOMAIN", "Beg": 21, "End": 165 }, { "InterPro-ID": "IPR005894", "InterPro-Name": "DrrA", "InterPro-Type": "FAMILY", "Beg": 13, "End": 307 }, { "InterPro-ID": "IPR025302", "InterPro-Name": "DrrA1-3-like_C", "InterPro-Type": "DOMAIN", "Beg": 218, "End": 305 }, { "InterPro-ID": "IPR003593", "InterPro-Name": "AAA+_ATPase", "InterPro-Type": "DOMAIN", "Beg": 30, "End": 213 }, { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 5, "End": 226 }, { "InterPro-ID": "IPR003439", "InterPro-Name": "ABC_transporter-like_ATP-bd", "InterPro-Type": "DOMAIN", "Beg": 6, "End": 236 }, { "InterPro-ID": "IPR017871", "InterPro-Name": "ABC_transporter-like_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 137, "End": 151 }, { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1, "End": 242 } ], "response#1": "MADTAITVDGAEKRYGDKKALDGLDLRVARGTVHGVLGPNGAGKTTLVRVLSTLLRPDAGRIEVSGHDVVREAYAVRLRIGLLGQHAALDEELGGRQNLELFGRLHHLGARRARARADELLERFDLADTGRKTVRQYSGGMRRRLDLAASLITEPEVLFLDEPTTGLDPRGRAEVWDSVRSLVGGGTTVLLTTQYLEEADQLADRISVVDAGRVIAEGTADELKAETGGDRIDVVLREAGQLGAAVALLPLTGVTVDTDRRLLSAPVTDRMEALSGVVRALQEAGIEAEDVALRRPTLDEVFLHLTGDDRRVKEAA", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more ABC_transporter-like_ATP-bd, DrrA1-3-like_C, AAA+_ATPase, ABC_transporter-like_ATP-bd that are essential for its biological function; 2. The protein should belong to ABC_transporter_ATP-binding, DrrA that shares evolutionary origin and functional similarity; 3. The protein should be classified within P-loop_NTPase, P-loop_NTPase sharing conserved structural features; 4. The protein should contain ABC_transporter-like_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MADTAITVDGAEKRYGDKKALDGLDLRVARGTVHGVLGPNGAGKTTLVRVLSTLLRPDAGRIEVSGHDVVREAYAVRLRIGLLGQHAALDEELGGRQNLELFGRLHHLGARRARARADELLERFDLADTGRKTVRQYSGGMRRRLDLAASLITEPEVLFLDEPTTGLDPRGRAEVWDSVRSLVGGGTTVLLTTQYLEEADQLADRISVVDAGRVIAEGTADELKAETGGDRIDVVLREAGQLGAAVALLPLTGVTVDTDRRLLSAPVTDRMEALSGVVRALQEAGIEAEDVALRRPTLDEVFLHLTGDDRRVKEAA" }, { "InterPro": [ { "InterPro-ID": "IPR036724", "InterPro-Name": "Cobalamin-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 64, "End": 139 }, { "InterPro-ID": "IPR006638", "InterPro-Name": "Elp3/MiaA/NifB-like_rSAM", "InterPro-Type": "DOMAIN", "Beg": 196, "End": 414 }, { "InterPro-ID": "IPR023404", "InterPro-Name": "rSAM_horseshoe", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 195, "End": 395 }, { "InterPro-ID": "IPR006158", "InterPro-Name": "Cobalamin-bd", "InterPro-Type": "DOMAIN", "Beg": 1, "End": 144 }, { "InterPro-ID": "IPR007197", "InterPro-Name": "rSAM", "InterPro-Type": "DOMAIN", "Beg": 192, "End": 417 }, { "InterPro-ID": "IPR006158", "InterPro-Name": "Cobalamin-bd", "InterPro-Type": "DOMAIN", "Beg": 64, "End": 134 }, { "InterPro-ID": "IPR034514", "InterPro-Name": "ThnK-like", "InterPro-Type": "FAMILY", "Beg": 3, "End": 681 }, { "InterPro-ID": "IPR051198", "InterPro-Name": "Tetrapyrrole_Bchl_Biosynth_MTs", "InterPro-Type": "FAMILY", "Beg": 61, "End": 403 }, { "InterPro-ID": "IPR034466", "InterPro-Name": "Methyltransferase_Class_B", "InterPro-Type": "FAMILY", "Beg": 3, "End": 681 } ], "response#1": "MTVPAARSGRKVYFIGLNAVPFLPLVAGLLRTYAEQDPRVAAGYDFQEPVFLVDGVQEMAAGITDPDVLALSCYVWNFRRQMKVARLVKERHPGMLVVAGGPHVPDRPGDFFARHPYVDVLVHGEGETAFRELLIERLADHPDYTRVPGVSVRHGTEAVPGRPAERLPRRIETPSPYLLGVMDGAVATCRQRDLRFYALWETNRGCPYSCAFCDWGSATMSALRLFDAERLQEEIEWFAEHDVEDLFVCDANFGILPRDLEIARALADARAATGAPKLIRVNFAKNSNDRVFEISKTWHDADLLMGTTLSMQSTDLDVLEAIDRKNIGLENYRKLQQRYATENIHTYTELILGLPLESPRSFRDGIGSLLEAGNHEDIRVYEFGILPNAPINTPEKIAGYGLRTVPKRLYVEEPGTPDDEAETVDMVMETNAMSRDEWVDCFGFVQAVQFLHNGCYTRYLSMYLRQRHDIGYTAFYERLQQYFGARPDTVLGSIYLRMRKLYHDYIDIPELPLANLVASQPDMAADLARYGKRRGWTIDNWGWLRIANDFERTYTELRDFVAALGVDDTSDPDLAEVFRFQQDVMLRPDYDPAAGRTTEYTADWPGYFTTGELRRRPVRMRLADQRFGANGRYTPVPGDLKAFARAAIGPSYPVSRIGHYRHRFEAAEVTSPAEPVLTEQR", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Elp3/MiaA/NifB-like_rSAM, Cobalamin-bd, rSAM, Cobalamin-bd that are essential for its biological function; 2. The protein should belong to ThnK-like, Tetrapyrrole_Bchl_Biosynth_MTs, Methyltransferase_Class_B that shares evolutionary origin and functional similarity; 3. The protein should be classified within Cobalamin-bd_sf, rSAM_horseshoe sharing conserved structural features. The designed protein sequence is ", "reference": "MTVPAARSGRKVYFIGLNAVPFLPLVAGLLRTYAEQDPRVAAGYDFQEPVFLVDGVQEMAAGITDPDVLALSCYVWNFRRQMKVARLVKERHPGMLVVAGGPHVPDRPGDFFARHPYVDVLVHGEGETAFRELLIERLADHPDYTRVPGVSVRHGTEAVPGRPAERLPRRIETPSPYLLGVMDGAVATCRQRDLRFYALWETNRGCPYSCAFCDWGSATMSALRLFDAERLQEEIEWFAEHDVEDLFVCDANFGILPRDLEIARALADARAATGAPKLIRVNFAKNSNDRVFEISKTWHDADLLMGTTLSMQSTDLDVLEAIDRKNIGLENYRKLQQRYATENIHTYTELILGLPLESPRSFRDGIGSLLEAGNHEDIRVYEFGILPNAPINTPEKIAGYGLRTVPKRLYVEEPGTPDDEAETVDMVMETNAMSRDEWVDCFGFVQAVQFLHNGCYTRYLSMYLRQRHDIGYTAFYERLQQYFGARPDTVLGSIYLRMRKLYHDYIDIPELPLANLVASQPDMAADLARYGKRRGWTIDNWGWLRIANDFERTYTELRDFVAALGVDDTSDPDLAEVFRFQQDVMLRPDYDPAAGRTTEYTADWPGYFTTGELRRRPVRMRLADQRFGANGRYTPVPGDLKAFARAAIGPSYPVSRIGHYRHRFEAAEVTSPAEPVLTEQR" }, { "InterPro": [ { "InterPro-ID": "IPR025302", "InterPro-Name": "DrrA1-3-like_C", "InterPro-Type": "DOMAIN", "Beg": 219, "End": 308 }, { "InterPro-ID": "IPR003439", "InterPro-Name": "ABC_transporter-like_ATP-bd", "InterPro-Type": "DOMAIN", "Beg": 21, "End": 165 }, { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 2, "End": 243 }, { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 8, "End": 225 }, { "InterPro-ID": "IPR005894", "InterPro-Name": "DrrA", "InterPro-Type": "FAMILY", "Beg": 13, "End": 310 }, { "InterPro-ID": "IPR017871", "InterPro-Name": "ABC_transporter-like_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 137, "End": 151 }, { "InterPro-ID": "IPR003593", "InterPro-Name": "AAA+_ATPase", "InterPro-Type": "DOMAIN", "Beg": 30, "End": 213 }, { "InterPro-ID": "IPR003439", "InterPro-Name": "ABC_transporter-like_ATP-bd", "InterPro-Type": "DOMAIN", "Beg": 6, "End": 236 }, { "InterPro-ID": "IPR050763", "InterPro-Name": "ABC_transporter_ATP-binding", "InterPro-Type": "FAMILY", "Beg": 5, "End": 315 } ], "response#1": "MDGYAVRAEAMEKRYGEKRALDGFDLAVGEGTVHGLLGPNGAGKTTAVRILSTLVRLDGGRATVAGLDVARQPREVRARIGLTGQYAAVDEVLTGRQNLEMFGRLFHLGGRRARLRATELLEQFDLTDAGDRGVGKYSGGMRRRLDLAASMILAPAVLFLDEPTTGLDPRSRGEVWESVRALVAGGTTVLLTTQYLEEADKLASRITVIDQGRAIADDTPDGLKNLVGGDRIEVVVAERAEIPRVVKVVARVADGEPEADETESRVHAPVTDRVTALTEVARTLQDEGVRVEDIGLRRPSLDDVFLRLTGHRTENTEAKEAA", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more DrrA1-3-like_C, ABC_transporter-like_ATP-bd, AAA+_ATPase, ABC_transporter-like_ATP-bd that are essential for its biological function; 2. The protein should belong to DrrA, ABC_transporter_ATP-binding that shares evolutionary origin and functional similarity; 3. The protein should be classified within P-loop_NTPase, P-loop_NTPase sharing conserved structural features; 4. The protein should contain ABC_transporter-like_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MDGYAVRAEAMEKRYGEKRALDGFDLAVGEGTVHGLLGPNGAGKTTAVRILSTLVRLDGGRATVAGLDVARQPREVRARIGLTGQYAAVDEVLTGRQNLEMFGRLFHLGGRRARLRATELLEQFDLTDAGDRGVGKYSGGMRRRLDLAASMILAPAVLFLDEPTTGLDPRSRGEVWESVRALVAGGTTVLLTTQYLEEADKLASRITVIDQGRAIADDTPDGLKNLVGGDRIEVVVAERAEIPRVVKVVARVADGEPEADETESRVHAPVTDRVTALTEVARTLQDEGVRVEDIGLRRPSLDDVFLRLTGHRTENTEAKEAA" }, { "InterPro": [ { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1, "End": 261 }, { "InterPro-ID": "IPR003593", "InterPro-Name": "AAA+_ATPase", "InterPro-Type": "DOMAIN", "Beg": 33, "End": 216 }, { "InterPro-ID": "IPR017871", "InterPro-Name": "ABC_transporter-like_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 140, "End": 154 }, { "InterPro-ID": "IPR050763", "InterPro-Name": "ABC_transporter_ATP-binding", "InterPro-Type": "FAMILY", "Beg": 7, "End": 317 }, { "InterPro-ID": "IPR003439", "InterPro-Name": "ABC_transporter-like_ATP-bd", "InterPro-Type": "DOMAIN", "Beg": 9, "End": 239 }, { "InterPro-ID": "IPR025302", "InterPro-Name": "DrrA1-3-like_C", "InterPro-Type": "DOMAIN", "Beg": 221, "End": 310 }, { "InterPro-ID": "IPR005894", "InterPro-Name": "DrrA", "InterPro-Type": "FAMILY", "Beg": 16, "End": 312 }, { "InterPro-ID": "IPR003439", "InterPro-Name": "ABC_transporter-like_ATP-bd", "InterPro-Type": "DOMAIN", "Beg": 25, "End": 168 }, { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 8, "End": 230 } ], "response#1": "MNTQPTRAIETSGLVKVYNGTRAVDGLDLDVPAGLVYGILGPNGAGKSTTIRMLATLLRPDGGTARVFGHDVTSEPDTVRRRISVTGQYASVDEGLTGTENLVMMGRLQGYSWARARERAAELIDGFGLGDARDRLLKTYSGGMRRRLDIAASIVVTPDLLFLDEPTTGLDPRSRNQVWDIVRALVDAGTTVLLTTQYLDEADQLADRIAVIDHGRVIAEGTTGELKSSLGSNVLRLRLHDAQSRAEAERLLSAELGVTIHRDSDPTALSARIDDPRQGMRALAELSRTQLEVRSFSLGQSSLDEVFLALTGHPADDRSTEEAAEEEKVA", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more AAA+_ATPase, ABC_transporter-like_ATP-bd, DrrA1-3-like_C, ABC_transporter-like_ATP-bd that are essential for its biological function; 2. The protein should belong to ABC_transporter_ATP-binding, DrrA that shares evolutionary origin and functional similarity; 3. The protein should be classified within P-loop_NTPase, P-loop_NTPase sharing conserved structural features; 4. The protein should contain ABC_transporter-like_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MNTQPTRAIETSGLVKVYNGTRAVDGLDLDVPAGLVYGILGPNGAGKSTTIRMLATLLRPDGGTARVFGHDVTSEPDTVRRRISVTGQYASVDEGLTGTENLVMMGRLQGYSWARARERAAELIDGFGLGDARDRLLKTYSGGMRRRLDIAASIVVTPDLLFLDEPTTGLDPRSRNQVWDIVRALVDAGTTVLLTTQYLDEADQLADRIAVIDHGRVIAEGTTGELKSSLGSNVLRLRLHDAQSRAEAERLLSAELGVTIHRDSDPTALSARIDDPRQGMRALAELSRTQLEVRSFSLGQSSLDEVFLALTGHPADDRSTEEAAEEEKVA" }, { "InterPro": [ { "InterPro-ID": "IPR006076", "InterPro-Name": "FAD-dep_OxRdtase", "InterPro-Type": "DOMAIN", "Beg": 99, "End": 482 }, { "InterPro-ID": "IPR036188", "InterPro-Name": "FAD/NAD-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 99, "End": 485 }, { "InterPro-ID": "IPR036188", "InterPro-Name": "FAD/NAD-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 97, "End": 509 } ], "response#1": "MLRYRQVVGLLQRRNFSAGATSNGSGSSGGDKSGEDLHPIRRTLRLLGNDMRKVKEFFVPKEPETEKVPIPTQSQFHFSGERDKSKEATVPDDFQTHCDVLIIGGGGVGSSIAYWLKEKARDGLNVVVVEKDDTYAQSATRVSVGGLCQQFSLPENIQMSLFAADFLRSARKHFGEEVPLQFTPHGHLMLAGEEHAESLKRSSQLQNELGARNELLTADRLTARFPWLNTKGIALGCLGLEKEGWFNPLALLSNFRRSASGYGAHFISGQVVDFEFKSQTDISVVTDLGSNEGAYTGLEKAVIQLPDGTRRTCKFALCVISAGASSEQIARLARIGVGPGILRVPLPINARKRYMYAINSQAQSAPGMNMPMTIDPSGIFIRRDGLGGNYICVQDSTEEYNSAMIDPQYFAQHIRPHLYNRIPVLGEAQVVDSWAGCYDHNVYDENGILGAHPYYNNLYLATGFSGHGVQQSLAVGRAISELIMDGQFRTIDLSRLSFDRLIVDQPMFELNNVLS", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more FAD-dep_OxRdtase that are essential for its biological function; 2. The protein should be classified within FAD/NAD-bd_sf, FAD/NAD-bd_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MLRYRQVVGLLQRRNFSAGATSNGSGSSGGDKSGEDLHPIRRTLRLLGNDMRKVKEFFVPKEPETEKVPIPTQSQFHFSGERDKSKEATVPDDFQTHCDVLIIGGGGVGSSIAYWLKEKARDGLNVVVVEKDDTYAQSATRVSVGGLCQQFSLPENIQMSLFAADFLRSARKHFGEEVPLQFTPHGHLMLAGEEHAESLKRSSQLQNELGARNELLTADRLTARFPWLNTKGIALGCLGLEKEGWFNPLALLSNFRRSASGYGAHFISGQVVDFEFKSQTDISVVTDLGSNEGAYTGLEKAVIQLPDGTRRTCKFALCVISAGASSEQIARLARIGVGPGILRVPLPINARKRYMYAINSQAQSAPGMNMPMTIDPSGIFIRRDGLGGNYICVQDSTEEYNSAMIDPQYFAQHIRPHLYNRIPVLGEAQVVDSWAGCYDHNVYDENGILGAHPYYNNLYLATGFSGHGVQQSLAVGRAISELIMDGQFRTIDLSRLSFDRLIVDQPMFELNNVLS" }, { "InterPro": [ { "InterPro-ID": "IPR051486", "InterPro-Name": "Hcy_S-methyltransferase", "InterPro-Type": "FAMILY", "Beg": 16, "End": 324 }, { "InterPro-ID": "IPR036589", "InterPro-Name": "HCY_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 11, "End": 327 }, { "InterPro-ID": "IPR003726", "InterPro-Name": "HCY_dom", "InterPro-Type": "DOMAIN", "Beg": 15, "End": 323 }, { "InterPro-ID": "IPR036589", "InterPro-Name": "HCY_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 4, "End": 323 }, { "InterPro-ID": "IPR003726", "InterPro-Name": "HCY_dom", "InterPro-Type": "DOMAIN", "Beg": 3, "End": 324 }, { "InterPro-ID": "IPR017226", "InterPro-Name": "Betaine-hCys_S-MeTrfase_BHMT", "InterPro-Type": "FAMILY", "Beg": 276, "End": 327 }, { "InterPro-ID": "IPR017226", "InterPro-Name": "Betaine-hCys_S-MeTrfase_BHMT", "InterPro-Type": "FAMILY", "Beg": 8, "End": 104 } ], "response#1": "MEVNQKWNWDTKPILVKCGGFSSQLAKNVTEKVDGDPLWGSRFDATNPEAVIQTHLDFLRNGADIILTNTYQSSVEGFVKYLGVTRERGVELIQKSVQLAKQAKEQYLSEIGSEAESALPLIMGSIGPYGAYLHDGSEYTGNYADKMSKEELRAWHKTRIEICLAAGVDGLALETLPCLMEAEAVTELVLDNFPDAKFWVSLQCMDEKHMASGENFAEAALSLWRLVQSRKAENRLLGIGLNCVNPLFVTPLLSSLTKVAGSDRIPLVVYSNRGEIYDVEQGDWTGTGEEVVKFVPEWIQLGVRIVGGCCRVYPTDVLAIRKYVDGLNIKP", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more HCY_dom, HCY_dom that are essential for its biological function; 2. The protein should belong to Hcy_S-methyltransferase, Betaine-hCys_S-MeTrfase_BHMT, Betaine-hCys_S-MeTrfase_BHMT that shares evolutionary origin and functional similarity; 3. The protein should be classified within HCY_dom_sf, HCY_dom_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MEVNQKWNWDTKPILVKCGGFSSQLAKNVTEKVDGDPLWGSRFDATNPEAVIQTHLDFLRNGADIILTNTYQSSVEGFVKYLGVTRERGVELIQKSVQLAKQAKEQYLSEIGSEAESALPLIMGSIGPYGAYLHDGSEYTGNYADKMSKEELRAWHKTRIEICLAAGVDGLALETLPCLMEAEAVTELVLDNFPDAKFWVSLQCMDEKHMASGENFAEAALSLWRLVQSRKAENRLLGIGLNCVNPLFVTPLLSSLTKVAGSDRIPLVVYSNRGEIYDVEQGDWTGTGEEVVKFVPEWIQLGVRIVGGCCRVYPTDVLAIRKYVDGLNIKP" }, { "InterPro": [ { "InterPro-ID": "IPR038381", "InterPro-Name": "HobA_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1, "End": 180 }, { "InterPro-ID": "IPR021011", "InterPro-Name": "HobA", "InterPro-Type": "FAMILY", "Beg": 1, "End": 180 } ], "response#1": "MKNFYDWIKEFVRDQGEFIAQQSGWLELERSSYAKLIAQTISHVLNGGSLLVSADSSRHWFLNYILSNLNPKDLKERPLLSVIDFNASSFYPKNDANLSLATIEMTYQNPMFWHVGKIENEGLKTILLSKIPSFLWLFEELKEDCLLLKEHDSLLDYKLLQLFKLFENALFSVLYNKVTL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to HobA that shares evolutionary origin and functional similarity; 2. The protein should be classified within HobA_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MKNFYDWIKEFVRDQGEFIAQQSGWLELERSSYAKLIAQTISHVLNGGSLLVSADSSRHWFLNYILSNLNPKDLKERPLLSVIDFNASSFYPKNDANLSLATIEMTYQNPMFWHVGKIENEGLKTILLSKIPSFLWLFEELKEDCLLLKEHDSLLDYKLLQLFKLFENALFSVLYNKVTL" }, { "InterPro": [ { "InterPro-ID": "IPR006638", "InterPro-Name": "Elp3/MiaA/NifB-like_rSAM", "InterPro-Type": "DOMAIN", "Beg": 303, "End": 529 }, { "InterPro-ID": "IPR007197", "InterPro-Name": "rSAM", "InterPro-Type": "DOMAIN", "Beg": 299, "End": 545 }, { "InterPro-ID": "IPR023404", "InterPro-Name": "rSAM_horseshoe", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 302, "End": 476 }, { "InterPro-ID": "IPR006158", "InterPro-Name": "Cobalamin-bd", "InterPro-Type": "DOMAIN", "Beg": 119, "End": 259 }, { "InterPro-ID": "IPR007197", "InterPro-Name": "rSAM", "InterPro-Type": "DOMAIN", "Beg": 308, "End": 470 }, { "InterPro-ID": "IPR034532", "InterPro-Name": "OxsB-like", "InterPro-Type": "FAMILY", "Beg": 1, "End": 744 }, { "InterPro-ID": "IPR051198", "InterPro-Name": "Tetrapyrrole_Bchl_Biosynth_MTs", "InterPro-Type": "FAMILY", "Beg": 122, "End": 497 }, { "InterPro-ID": "IPR007197", "InterPro-Name": "rSAM", "InterPro-Type": "DOMAIN", "Beg": 1, "End": 744 } ], "response#1": "MQTYLSTKSIEYYLKELKEIFSQIWLKPSEIEKRCEELFKRSKEFDYKRILVSGETDNTTLYVIEDSSKIHVFSPNRDLRENPLLMRWHPSWYEIESKEIYYKCFLSCEELYEHLELPTVTLVNLCVIENFPIPRLNLSTGTLSSYLRKEQLAKVELIDMQVGTTINQIIKNLLDSQPDIIGLSVNFGQKKLAFEILDLIYSHIENGDLSSIITVGNVIPSFSPEQFFERYPSLLICDKEGEYTLRDLIKMLKKELKLDEVNGISYVDESGEVKHNVAETVNFKEEVPTPSLDILGEISKFRGALTLETSRGCDYSRCTFCPRDHKLRSWRPLSVEQTLKQLDDILRAGKHFNIKPHIYMADEEFIGELPNGTEAQRIIDICEGLLKREEKIKFDFAARADSVYEPKRTKEWNVERLKMWHYCALAGADRIFIGVESGSNQQLKRYGKGTTSEQNIIALRLVSALGINLRIGFIMFDQLMKGLDNLKENLDFLERTDALMKPIDIGDMTYEELYDKLLNDKEFIEKHKTGKPVYTIVSYMLASMEILMNTPYSRMVQLTERKEEVNLIMNDGKPDMNMGRYATSFVDKTNGNLSEACQMWIDSNFGVMYTIKSLHKVANPREKKKLYSYMETHREISHFLLKYLVYNLSPDKESQIILSDFLRMHSMEHILDNSKINVGDGSKENILNVMTNWQLIMEKLLRDVEADLNKGIITDSEDHRLHNTLKRWFSDMGNWSLINAYELN", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Elp3/MiaA/NifB-like_rSAM, rSAM, Cobalamin-bd, rSAM, rSAM that are essential for its biological function; 2. The protein should belong to OxsB-like, Tetrapyrrole_Bchl_Biosynth_MTs that shares evolutionary origin and functional similarity; 3. The protein should be classified within rSAM_horseshoe sharing conserved structural features. The designed protein sequence is ", "reference": "MQTYLSTKSIEYYLKELKEIFSQIWLKPSEIEKRCEELFKRSKEFDYKRILVSGETDNTTLYVIEDSSKIHVFSPNRDLRENPLLMRWHPSWYEIESKEIYYKCFLSCEELYEHLELPTVTLVNLCVIENFPIPRLNLSTGTLSSYLRKEQLAKVELIDMQVGTTINQIIKNLLDSQPDIIGLSVNFGQKKLAFEILDLIYSHIENGDLSSIITVGNVIPSFSPEQFFERYPSLLICDKEGEYTLRDLIKMLKKELKLDEVNGISYVDESGEVKHNVAETVNFKEEVPTPSLDILGEISKFRGALTLETSRGCDYSRCTFCPRDHKLRSWRPLSVEQTLKQLDDILRAGKHFNIKPHIYMADEEFIGELPNGTEAQRIIDICEGLLKREEKIKFDFAARADSVYEPKRTKEWNVERLKMWHYCALAGADRIFIGVESGSNQQLKRYGKGTTSEQNIIALRLVSALGINLRIGFIMFDQLMKGLDNLKENLDFLERTDALMKPIDIGDMTYEELYDKLLNDKEFIEKHKTGKPVYTIVSYMLASMEILMNTPYSRMVQLTERKEEVNLIMNDGKPDMNMGRYATSFVDKTNGNLSEACQMWIDSNFGVMYTIKSLHKVANPREKKKLYSYMETHREISHFLLKYLVYNLSPDKESQIILSDFLRMHSMEHILDNSKINVGDGSKENILNVMTNWQLIMEKLLRDVEADLNKGIITDSEDHRLHNTLKRWFSDMGNWSLINAYELN" }, { "InterPro": [ { "InterPro-ID": "IPR003607", "InterPro-Name": "HD/PDEase_dom", "InterPro-Type": "DOMAIN", "Beg": 26, "End": 94 }, { "InterPro-ID": "IPR003607", "InterPro-Name": "HD/PDEase_dom", "InterPro-Type": "DOMAIN", "Beg": 24, "End": 146 } ], "response#1": "MSSLLDIIYQLRQVPRWDGSFQFEKEDVSQHSFSVIAISHILCELKETLEGKKINKEKLLLYALYHDVTEVVSTHIISPVKKNSILKDPFNAFREQIKNSLFDNLPITLSDTLSTILNNNDLEIQEIVEHADHVDAYCKSCIEVHRGNKDFISIQRSLGDKLDNLTKEYPYLKEFQNLFLKDFPLENKNYRYLN", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more HD/PDEase_dom, HD/PDEase_dom that are essential for its biological function. The designed protein sequence is ", "reference": "MSSLLDIIYQLRQVPRWDGSFQFEKEDVSQHSFSVIAISHILCELKETLEGKKINKEKLLLYALYHDVTEVVSTHIISPVKKNSILKDPFNAFREQIKNSLFDNLPITLSDTLSTILNNNDLEIQEIVEHADHVDAYCKSCIEVHRGNKDFISIQRSLGDKLDNLTKEYPYLKEFQNLFLKDFPLENKNYRYLN" }, { "InterPro": [ { "InterPro-ID": "IPR050109", "InterPro-Name": "HTH-type_TetR-like_transc_reg", "InterPro-Type": "FAMILY", "Beg": 27, "End": 224 }, { "InterPro-ID": "IPR001647", "InterPro-Name": "HTH_TetR", "InterPro-Type": "DOMAIN", "Beg": 44, "End": 90 }, { "InterPro-ID": "IPR001647", "InterPro-Name": "HTH_TetR", "InterPro-Type": "DOMAIN", "Beg": 44, "End": 57 }, { "InterPro-ID": "IPR001647", "InterPro-Name": "HTH_TetR", "InterPro-Type": "DOMAIN", "Beg": 65, "End": 88 }, { "InterPro-ID": "IPR054129", "InterPro-Name": "DesT_TetR_C", "InterPro-Type": "DOMAIN", "Beg": 113, "End": 218 }, { "InterPro-ID": "IPR009057", "InterPro-Name": "Homeodomain-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 31, "End": 115 }, { "InterPro-ID": "IPR001647", "InterPro-Name": "HTH_TetR", "InterPro-Type": "DOMAIN", "Beg": 38, "End": 98 }, { "InterPro-ID": "IPR036271", "InterPro-Name": "Tet_transcr_reg_TetR-rel_C_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 110, "End": 222 } ], "response#1": "MSDLAKTAQRRALRSSGSARPDEDVPAPNRRGNRLPRDERRGQLLVVASDVFVDRGYHAAGMDEIADRAGVSKPVLYQHFSSKLELYLAVLHRHVENLVSGVHQALSTTTDNRQRLHVAVQAFFDFIEHDSQGYRLIFENDFVTEPEVAAQVRVATESCIDAVFALISADSGLDPHRARMIAVGLVGMSVDCARYWLDADKPISKSDAVEGTVQFAWGGLSHVPLTRS", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more HTH_TetR, HTH_TetR, HTH_TetR, DesT_TetR_C, HTH_TetR that are essential for its biological function; 2. The protein should belong to HTH-type_TetR-like_transc_reg that shares evolutionary origin and functional similarity; 3. The protein should be classified within Homeodomain-like_sf, Tet_transcr_reg_TetR-rel_C_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MSDLAKTAQRRALRSSGSARPDEDVPAPNRRGNRLPRDERRGQLLVVASDVFVDRGYHAAGMDEIADRAGVSKPVLYQHFSSKLELYLAVLHRHVENLVSGVHQALSTTTDNRQRLHVAVQAFFDFIEHDSQGYRLIFENDFVTEPEVAAQVRVATESCIDAVFALISADSGLDPHRARMIAVGLVGMSVDCARYWLDADKPISKSDAVEGTVQFAWGGLSHVPLTRS" }, { "InterPro": [ { "InterPro-ID": "IPR001000", "InterPro-Name": "GH10_dom", "InterPro-Type": "DOMAIN", "Beg": 42, "End": 349 }, { "InterPro-ID": "IPR001000", "InterPro-Name": "GH10_dom", "InterPro-Type": "DOMAIN", "Beg": 225, "End": 237 }, { "InterPro-ID": "IPR001000", "InterPro-Name": "GH10_dom", "InterPro-Type": "DOMAIN", "Beg": 158, "End": 169 }, { "InterPro-ID": "IPR001000", "InterPro-Name": "GH10_dom", "InterPro-Type": "DOMAIN", "Beg": 114, "End": 126 }, { "InterPro-ID": "IPR001000", "InterPro-Name": "GH10_dom", "InterPro-Type": "DOMAIN", "Beg": 196, "End": 207 }, { "InterPro-ID": "IPR001000", "InterPro-Name": "GH10_dom", "InterPro-Type": "DOMAIN", "Beg": 40, "End": 352 }, { "InterPro-ID": "IPR044846", "InterPro-Name": "GH10", "InterPro-Type": "FAMILY", "Beg": 63, "End": 351 }, { "InterPro-ID": "IPR001000", "InterPro-Name": "GH10_dom", "InterPro-Type": "DOMAIN", "Beg": 83, "End": 353 }, { "InterPro-ID": "IPR017853", "InterPro-Name": "Glycoside_hydrolase_SF", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 48, "End": 355 } ], "response#1": "MRFSASLLLALTGSAAASPIRAEEEIRVYDLPISLFDDLQGLDAAMKAAGREYIGTSLTVRNDFQEQNIIRTEFGSITPENAQKWDATEPNRGQFTFGSADQHMDWARQNGKHVRCHTLVWYSQLPGWVSNSGFNNATLQQVMQNHINQVMGRYRGRCNHWDVVNEAPRLMAMRLQIGEAYIPIAFRMAAQADPSAKLYYNDYNLEYLGPKVEGAARIVRLVKQYGARIDGVGYQAHLVTEPTPTQSTPTPSEEDLIKALRITADLGVDVAYTEIDIRMRTPSNAQKLQQLADAYYRVARSCMKVPRCVGMTIWGVTDRYSWVPNTFRGEGDALLWDSNYQRKAAYNAFLRGIQEPVN", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more GH10_dom, GH10_dom, GH10_dom, GH10_dom, GH10_dom, GH10_dom, GH10_dom that are essential for its biological function; 2. The protein should belong to GH10 that shares evolutionary origin and functional similarity; 3. The protein should be classified within Glycoside_hydrolase_SF sharing conserved structural features. The designed protein sequence is ", "reference": "MRFSASLLLALTGSAAASPIRAEEEIRVYDLPISLFDDLQGLDAAMKAAGREYIGTSLTVRNDFQEQNIIRTEFGSITPENAQKWDATEPNRGQFTFGSADQHMDWARQNGKHVRCHTLVWYSQLPGWVSNSGFNNATLQQVMQNHINQVMGRYRGRCNHWDVVNEAPRLMAMRLQIGEAYIPIAFRMAAQADPSAKLYYNDYNLEYLGPKVEGAARIVRLVKQYGARIDGVGYQAHLVTEPTPTQSTPTPSEEDLIKALRITADLGVDVAYTEIDIRMRTPSNAQKLQQLADAYYRVARSCMKVPRCVGMTIWGVTDRYSWVPNTFRGEGDALLWDSNYQRKAAYNAFLRGIQEPVN" }, { "InterPro": [ { "InterPro-ID": "IPR001000", "InterPro-Name": "GH10_dom", "InterPro-Type": "DOMAIN", "Beg": 35, "End": 355 }, { "InterPro-ID": "IPR044846", "InterPro-Name": "GH10", "InterPro-Type": "FAMILY", "Beg": 73, "End": 320 }, { "InterPro-ID": "IPR001000", "InterPro-Name": "GH10_dom", "InterPro-Type": "DOMAIN", "Beg": 235, "End": 247 }, { "InterPro-ID": "IPR001000", "InterPro-Name": "GH10_dom", "InterPro-Type": "DOMAIN", "Beg": 206, "End": 217 }, { "InterPro-ID": "IPR001000", "InterPro-Name": "GH10_dom", "InterPro-Type": "DOMAIN", "Beg": 118, "End": 130 }, { "InterPro-ID": "IPR001000", "InterPro-Name": "GH10_dom", "InterPro-Type": "DOMAIN", "Beg": 162, "End": 173 }, { "InterPro-ID": "IPR001000", "InterPro-Name": "GH10_dom", "InterPro-Type": "DOMAIN", "Beg": 87, "End": 356 }, { "InterPro-ID": "IPR001000", "InterPro-Name": "GH10_dom", "InterPro-Type": "DOMAIN", "Beg": 55, "End": 355 }, { "InterPro-ID": "IPR017853", "InterPro-Name": "Glycoside_hydrolase_SF", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 41, "End": 360 } ], "response#1": "MHLASSLFLLATLPFGFAAGKGKGKGKDNSDVGLDVLAKKAGLKYFGAATDTPGQRERAGLEDKYPEYDRIMWHSPEFGSTTPTNGQKWLFVEPERGVFNFTEGDVVASKARQHGKLLRCHALVWHSQLAPWVEETEWTPEELRKVIVDHITAVAGHYKGQCYAWDVVNEALNEDGTYRESVFYKVLGEEYIKLAFETAAKVDPKAKLYYNDYNLEWPSAKTEGAKRIVKLLKDAKIPIHGVGLQAHLIAEQHPTLDDHIAAIRGFTQLGVEVALTELDIRLKTPATEENLALQREAYKNVVGACVQVCGCVGVTIWDFYDPFSWVPYFFEGEGAPLLWFEDFSKHPAYYGVVEALTNKTRRSKRSISDRRAKLLA", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more GH10_dom, GH10_dom, GH10_dom, GH10_dom, GH10_dom, GH10_dom, GH10_dom that are essential for its biological function; 2. The protein should belong to GH10 that shares evolutionary origin and functional similarity; 3. The protein should be classified within Glycoside_hydrolase_SF sharing conserved structural features. The designed protein sequence is ", "reference": "MHLASSLFLLATLPFGFAAGKGKGKGKDNSDVGLDVLAKKAGLKYFGAATDTPGQRERAGLEDKYPEYDRIMWHSPEFGSTTPTNGQKWLFVEPERGVFNFTEGDVVASKARQHGKLLRCHALVWHSQLAPWVEETEWTPEELRKVIVDHITAVAGHYKGQCYAWDVVNEALNEDGTYRESVFYKVLGEEYIKLAFETAAKVDPKAKLYYNDYNLEWPSAKTEGAKRIVKLLKDAKIPIHGVGLQAHLIAEQHPTLDDHIAAIRGFTQLGVEVALTELDIRLKTPATEENLALQREAYKNVVGACVQVCGCVGVTIWDFYDPFSWVPYFFEGEGAPLLWFEDFSKHPAYYGVVEALTNKTRRSKRSISDRRAKLLA" }, { "InterPro": [ { "InterPro-ID": "IPR001000", "InterPro-Name": "GH10_dom", "InterPro-Type": "DOMAIN", "Beg": 91, "End": 388 }, { "InterPro-ID": "IPR017853", "InterPro-Name": "Glycoside_hydrolase_SF", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 94, "End": 390 }, { "InterPro-ID": "IPR001000", "InterPro-Name": "GH10_dom", "InterPro-Type": "DOMAIN", "Beg": 165, "End": 177 }, { "InterPro-ID": "IPR001000", "InterPro-Name": "GH10_dom", "InterPro-Type": "DOMAIN", "Beg": 282, "End": 294 }, { "InterPro-ID": "IPR001000", "InterPro-Name": "GH10_dom", "InterPro-Type": "DOMAIN", "Beg": 252, "End": 263 }, { "InterPro-ID": "IPR001000", "InterPro-Name": "GH10_dom", "InterPro-Type": "DOMAIN", "Beg": 208, "End": 219 }, { "InterPro-ID": "IPR035971", "InterPro-Name": "CBD_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 19, "End": 52 }, { "InterPro-ID": "IPR001000", "InterPro-Name": "GH10_dom", "InterPro-Type": "DOMAIN", "Beg": 134, "End": 390 }, { "InterPro-ID": "IPR001000", "InterPro-Name": "GH10_dom", "InterPro-Type": "DOMAIN", "Beg": 85, "End": 389 }, { "InterPro-ID": "IPR000254", "InterPro-Name": "Cellulose-bd_dom_fun", "InterPro-Type": "DOMAIN", "Beg": 19, "End": 52 }, { "InterPro-ID": "IPR000254", "InterPro-Name": "Cellulose-bd_dom_fun", "InterPro-Type": "DOMAIN", "Beg": 20, "End": 48 }, { "InterPro-ID": "IPR000254", "InterPro-Name": "Cellulose-bd_dom_fun", "InterPro-Type": "DOMAIN", "Beg": 24, "End": 51 }, { "InterPro-ID": "IPR044846", "InterPro-Name": "GH10", "InterPro-Type": "FAMILY", "Beg": 101, "End": 381 }, { "InterPro-ID": "IPR000254", "InterPro-Name": "Cellulose-bd_dom_fun", "InterPro-Type": "DOMAIN", "Beg": 16, "End": 52 } ], "response#1": "MRSIALALAAAPAVLAQSQLWGQCGGIGWNGPTTCVSGATCTKINDWYHQCLPGGNNNNPPPATTSQWTPPPAQTSSNPPPNNGGGGGNTLHEKFKARGKQYFGTEIDHYHLNNNQLMEIARREFGQITHENSMKWDATEPSRGSFSFGNADRVVDWATSNGKLIRGHTLLWHSQLPQWVQNINDRNTLTQVIENHVKTIMTRYKGKIFHYDVVNEILDENGGLRNSVFSRVLGEDFVGIAFRAARATDPDAKLYINDYNLDSANYAKTRGMINLVNKWVSQGVPIDGIGTQAHLAGPGGWNPASGVPAALQALAGANVKEVAITELDIQGAGANDYVTVANACLNVQKCVGITVWGVSDRDSWRSNENPLLYDGSYRPKAAYNALMNAL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more GH10_dom, GH10_dom, GH10_dom, GH10_dom, GH10_dom, GH10_dom, GH10_dom, Cellulose-bd_dom_fun, Cellulose-bd_dom_fun, Cellulose-bd_dom_fun, Cellulose-bd_dom_fun that are essential for its biological function; 2. The protein should belong to GH10 that shares evolutionary origin and functional similarity; 3. The protein should be classified within Glycoside_hydrolase_SF, CBD_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MRSIALALAAAPAVLAQSQLWGQCGGIGWNGPTTCVSGATCTKINDWYHQCLPGGNNNNPPPATTSQWTPPPAQTSSNPPPNNGGGGGNTLHEKFKARGKQYFGTEIDHYHLNNNQLMEIARREFGQITHENSMKWDATEPSRGSFSFGNADRVVDWATSNGKLIRGHTLLWHSQLPQWVQNINDRNTLTQVIENHVKTIMTRYKGKIFHYDVVNEILDENGGLRNSVFSRVLGEDFVGIAFRAARATDPDAKLYINDYNLDSANYAKTRGMINLVNKWVSQGVPIDGIGTQAHLAGPGGWNPASGVPAALQALAGANVKEVAITELDIQGAGANDYVTVANACLNVQKCVGITVWGVSDRDSWRSNENPLLYDGSYRPKAAYNALMNAL" }, { "InterPro": [ { "InterPro-ID": "IPR036412", "InterPro-Name": "HAD-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 2, "End": 214 }, { "InterPro-ID": "IPR041492", "InterPro-Name": "HAD_2", "InterPro-Type": "FAMILY", "Beg": 5, "End": 187 }, { "InterPro-ID": "IPR050155", "InterPro-Name": "HAD-like_hydrolase_sf", "InterPro-Type": "FAMILY", "Beg": 4, "End": 214 }, { "InterPro-ID": "IPR023214", "InterPro-Name": "HAD_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 5, "End": 207 }, { "InterPro-ID": "IPR006439", "InterPro-Name": "HAD-SF_hydro_IA", "InterPro-Type": "FAMILY", "Beg": 101, "End": 181 }, { "InterPro-ID": "IPR023198", "InterPro-Name": "PGP-like_dom2", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 17, "End": 84 }, { "InterPro-ID": "IPR006439", "InterPro-Name": "HAD-SF_hydro_IA", "InterPro-Type": "FAMILY", "Beg": 114, "End": 187 }, { "InterPro-ID": "IPR006439", "InterPro-Name": "HAD-SF_hydro_IA", "InterPro-Type": "FAMILY", "Beg": 131, "End": 147 }, { "InterPro-ID": "IPR006439", "InterPro-Name": "HAD-SF_hydro_IA", "InterPro-Type": "FAMILY", "Beg": 100, "End": 113 }, { "InterPro-ID": "IPR006439", "InterPro-Name": "HAD-SF_hydro_IA", "InterPro-Type": "FAMILY", "Beg": 2, "End": 13 } ], "response#1": "MKPLVIFDLDGTLVDTPSGIVSAFITALRDLSMPFEDRRAIRATIGLPLEKAFGQILALPVEDERVTAAVRQYQAVFREQVLPQAPGLVFPGVVEGLALLKGQGYTLAVATSKVFASAKALLEAAGLWSYFDLVLGADMVAHPKPHPEMGLLAMSRLGADAATTAMVGDTTHDLLMAKQAGMAAIGVTWGIHTTDQLKAAEPQVIVDTFSEVVGAAHALLKLSSSPVSYC", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to HAD_2, HAD-like_hydrolase_sf, HAD-SF_hydro_IA, HAD-SF_hydro_IA, HAD-SF_hydro_IA, HAD-SF_hydro_IA, HAD-SF_hydro_IA that shares evolutionary origin and functional similarity; 2. The protein should be classified within HAD-like_sf, HAD_sf, PGP-like_dom2 sharing conserved structural features. The designed protein sequence is ", "reference": "MKPLVIFDLDGTLVDTPSGIVSAFITALRDLSMPFEDRRAIRATIGLPLEKAFGQILALPVEDERVTAAVRQYQAVFREQVLPQAPGLVFPGVVEGLALLKGQGYTLAVATSKVFASAKALLEAAGLWSYFDLVLGADMVAHPKPHPEMGLLAMSRLGADAATTAMVGDTTHDLLMAKQAGMAAIGVTWGIHTTDQLKAAEPQVIVDTFSEVVGAAHALLKLSSSPVSYC" }, { "InterPro": [ { "InterPro-ID": "IPR009801", "InterPro-Name": "TMEM126", "InterPro-Type": "FAMILY", "Beg": 44, "End": 194 }, { "InterPro-ID": "IPR009801", "InterPro-Name": "TMEM126", "InterPro-Type": "FAMILY", "Beg": 5, "End": 209 } ], "response#1": "MALSRAKPDELPRDAVVITEDQALKYQWKIITSWDKIGEVWSLRYTPGILSALAAGTGAYINNHYRTKLRLGGHGRLSTYLPIVAVPAIFTMLAHKFFIQRPILLNPLGECPVCIQMRSAAFQTSLGIVYPTILAPFAAFLFATRCYTYRIPSITENPREVFLLWRKFTRPIVPALGTLIGLQALLTMFLTGQEDKQNFKLMLRMREIEHQVEEEHLPQRMDF", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to TMEM126, TMEM126 that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MALSRAKPDELPRDAVVITEDQALKYQWKIITSWDKIGEVWSLRYTPGILSALAAGTGAYINNHYRTKLRLGGHGRLSTYLPIVAVPAIFTMLAHKFFIQRPILLNPLGECPVCIQMRSAAFQTSLGIVYPTILAPFAAFLFATRCYTYRIPSITENPREVFLLWRKFTRPIVPALGTLIGLQALLTMFLTGQEDKQNFKLMLRMREIEHQVEEEHLPQRMDF" }, { "InterPro": [ { "InterPro-ID": "IPR052299", "InterPro-Name": "CEP76", "InterPro-Type": "FAMILY", "Beg": 9, "End": 1120 }, { "InterPro-ID": "IPR056288", "InterPro-Name": "CEP76_C", "InterPro-Type": "DOMAIN", "Beg": 989, "End": 1126 }, { "InterPro-ID": "IPR035892", "InterPro-Name": "C2_domain_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 503, "End": 642 }, { "InterPro-ID": "IPR056290", "InterPro-Name": "CEPT76/DRC7_peptidase-like_dom", "InterPro-Type": "DOMAIN", "Beg": 785, "End": 861 }, { "InterPro-ID": "IPR000008", "InterPro-Name": "C2_dom", "InterPro-Type": "DOMAIN", "Beg": 515, "End": 574 }, { "InterPro-ID": "IPR000008", "InterPro-Name": "C2_dom", "InterPro-Type": "DOMAIN", "Beg": 497, "End": 623 }, { "InterPro-ID": "IPR000008", "InterPro-Name": "C2_dom", "InterPro-Type": "DOMAIN", "Beg": 515, "End": 621 }, { "InterPro-ID": "IPR000008", "InterPro-Name": "C2_dom", "InterPro-Type": "DOMAIN", "Beg": 350, "End": 460 }, { "InterPro-ID": "IPR035892", "InterPro-Name": "C2_domain_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 508, "End": 616 } ], "response#1": "MILDKFKNIVNLSNSNTEKEEGKNAEINENNDPNTQLAHEPSIVEADEKTFFDEMLGAPQYTYDEFLQVLKNPIEERGDTEDMKKHWGYPRRWKVILWDLHIQNYMNNDFNAFVDFDFGGNREECRIQRGSTMKIYAKGKTKNCLRTPVVTNVATEQKKNMNFRNVFEYRGSYLDLENEKLRIRVWEYKQFTLNKLEGIYEEPLLSFAVGEIYNETTLYKFIKDSRVKRCRLYFQLYFQELYDFELSFLNWSFSDLLSSSYIQAKSYNYLSNKNNVKKRYIDDTSCNIFPHMCKNFKRFHKKKIYRKVRNYDIDKNFSFNTALSDDSDERKNKNDRTIKNLEKLFVRNLTLMQNIEENEDMSYKNLQNINLPNPRVTITLSHTPKGHEGLNIISIEQKSIRFPIWENLGEIYFRGTLRDLDVSYLNIKVEDMSAPKSAREIGTCQISLKGIVDYPYVMHELEAPSWLVKEAKYEGWENKLNEWKLGTVEGKVIINRVPRYRQRGDIYHIDSKQPYLIVHIFNIDKIITVDNIKELDTYVEVSFDETSRRTRLMKKTLSPNYDSQISIPLRFNNKNDINYENLSKKGLIYIDVWGKSEDIVYIGGISISPYEIFFNEKNVRRNKTKLEHIDLETNVKITYDTVVYRGCKKLCFLHDDQRMSNIHFSIWTYPDILGNSTNQKKIVAPVSFNTTMNFPIKLAEKYNKLKKLFMEVLKTIKSIPENCTDVNTSTRFYNYELINQRKEKHFLPTLITSIKSPYCAESMNAIFHYVRCIPFIHKKENIIFTPDFTLQLKGGNALDHSLLLCSLFLGIPVLAFVCFGTLWDKQKHSWVATFEYNDEKNYGIVKFWETTTGNVYILKKRFIDHNRLKGLELKLKESKYKSHLRNGFLQRYENNTDINYIKEQTKRHIKQLFKNRINDIPIGGPSLPYKTIDLIFNHKNIYVNLQHSSPLNIWYDYWKFDFWFPFSSIEYNLQPSFTIKSFTHKMEDMELDKIAKELRTNIEKNINIYRASRNLSTRWNRDETLEIFLQVGLELLHQLNTSRKEDVLLAKLKIEDWKKALYHKVPQSHRLLGFPYHFNTYKSKFISDKLISTLAILESRDRSLCLSLAVCLYSLPGNFISCYIYIITCVKITQRELRKMEIIKEKAQRMAEIKNSQKKKKSSDDQNIDIKTMDDVEEKETFSSTNLDDTLHDEHTDIDTEKKKHEKDNYKNKKIKNTKLKDANIDNEEKDDHHHITDKKVSKSSDLIHSFDKNDISKNTFDKEEFINNLDKDKKYSSFKKGNVVNKKVSIKNEPSINIYEDHKIYDDENISNNIDNMENNQDEIYNLRQGKTIINEFQQVKKPQKYTINEKRDDIKTKKKRSKEKKKQDKLEFEKLIQSNAYFEQEKKKLQEDIKKLEKDKEQFQKEKIRREEKEKQLLLEEKIKLQKEKELFENEKLERKMSYMLKINELEKKKNERNKMEKSYKRMIQKDKEKKKKKESRDKIRRGEEEKMSADENMKEEQKMREEQKVGEEQKVGEEQKVGEEQKLREEQKMREEQKMREEQKMREEQKMREEQKVREEQKMREEQKMREEQKMREEQKVREEQKLREEQKMREEQKMREEQKMREEEKIREEEQMKREKKMRREEKKKRVQEPIKIDEIQVYDIIKNEKMKKKEEKEEKKRKKKKEDIEDKYKIGKEASLDENNNERQIKSKNIQEISDYEYKNIKENKNLNKFDEKLDLNQIYSKASNFYDNQEKKRRTIKVHANRKENSDSTFSHIDDSIKNKKEYLEDSNIARYLYEKRKHDLIGKGNYNFDEPHYGKKMNNVAYQDIKGSNLFKGFIEEPSSKKSPQKKKIVIVRKN", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more CEP76_C, CEPT76/DRC7_peptidase-like_dom, C2_dom, C2_dom, C2_dom, C2_dom that are essential for its biological function; 2. The protein should belong to CEP76 that shares evolutionary origin and functional similarity; 3. The protein should be classified within C2_domain_sf, C2_domain_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MILDKFKNIVNLSNSNTEKEEGKNAEINENNDPNTQLAHEPSIVEADEKTFFDEMLGAPQYTYDEFLQVLKNPIEERGDTEDMKKHWGYPRRWKVILWDLHIQNYMNNDFNAFVDFDFGGNREECRIQRGSTMKIYAKGKTKNCLRTPVVTNVATEQKKNMNFRNVFEYRGSYLDLENEKLRIRVWEYKQFTLNKLEGIYEEPLLSFAVGEIYNETTLYKFIKDSRVKRCRLYFQLYFQELYDFELSFLNWSFSDLLSSSYIQAKSYNYLSNKNNVKKRYIDDTSCNIFPHMCKNFKRFHKKKIYRKVRNYDIDKNFSFNTALSDDSDERKNKNDRTIKNLEKLFVRNLTLMQNIEENEDMSYKNLQNINLPNPRVTITLSHTPKGHEGLNIISIEQKSIRFPIWENLGEIYFRGTLRDLDVSYLNIKVEDMSAPKSAREIGTCQISLKGIVDYPYVMHELEAPSWLVKEAKYEGWENKLNEWKLGTVEGKVIINRVPRYRQRGDIYHIDSKQPYLIVHIFNIDKIITVDNIKELDTYVEVSFDETSRRTRLMKKTLSPNYDSQISIPLRFNNKNDINYENLSKKGLIYIDVWGKSEDIVYIGGISISPYEIFFNEKNVRRNKTKLEHIDLETNVKITYDTVVYRGCKKLCFLHDDQRMSNIHFSIWTYPDILGNSTNQKKIVAPVSFNTTMNFPIKLAEKYNKLKKLFMEVLKTIKSIPENCTDVNTSTRFYNYELINQRKEKHFLPTLITSIKSPYCAESMNAIFHYVRCIPFIHKKENIIFTPDFTLQLKGGNALDHSLLLCSLFLGIPVLAFVCFGTLWDKQKHSWVATFEYNDEKNYGIVKFWETTTGNVYILKKRFIDHNRLKGLELKLKESKYKSHLRNGFLQRYENNTDINYIKEQTKRHIKQLFKNRINDIPIGGPSLPYKTIDLIFNHKNIYVNLQHSSPLNIWYDYWKFDFWFPFSSIEYNLQPSFTIKSFTHKMEDMELDKIAKELRTNIEKNINIYRASRNLSTRWNRDETLEIFLQVGLELLHQLNTSRKEDVLLAKLKIEDWKKALYHKVPQSHRLLGFPYHFNTYKSKFISDKLISTLAILESRDRSLCLSLAVCLYSLPGNFISCYIYIITCVKITQRELRKMEIIKEKAQRMAEIKNSQKKKKSSDDQNIDIKTMDDVEEKETFSSTNLDDTLHDEHTDIDTEKKKHEKDNYKNKKIKNTKLKDANIDNEEKDDHHHITDKKVSKSSDLIHSFDKNDISKNTFDKEEFINNLDKDKKYSSFKKGNVVNKKVSIKNEPSINIYEDHKIYDDENISNNIDNMENNQDEIYNLRQGKTIINEFQQVKKPQKYTINEKRDDIKTKKKRSKEKKKQDKLEFEKLIQSNAYFEQEKKKLQEDIKKLEKDKEQFQKEKIRREEKEKQLLLEEKIKLQKEKELFENEKLERKMSYMLKINELEKKKNERNKMEKSYKRMIQKDKEKKKKKESRDKIRRGEEEKMSADENMKEEQKMREEQKVGEEQKVGEEQKVGEEQKLREEQKMREEQKMREEQKMREEQKMREEQKVREEQKMREEQKMREEQKMREEQKVREEQKLREEQKMREEQKMREEQKMREEEKIREEEQMKREKKMRREEKKKRVQEPIKIDEIQVYDIIKNEKMKKKEEKEEKKRKKKKEDIEDKYKIGKEASLDENNNERQIKSKNIQEISDYEYKNIKENKNLNKFDEKLDLNQIYSKASNFYDNQEKKRRTIKVHANRKENSDSTFSHIDDSIKNKKEYLEDSNIARYLYEKRKHDLIGKGNYNFDEPHYGKKMNNVAYQDIKGSNLFKGFIEEPSSKKSPQKKKIVIVRKN" }, { "InterPro": [ { "InterPro-ID": "IPR013562", "InterPro-Name": "TmcA_N", "InterPro-Type": "DOMAIN", "Beg": 28, "End": 219 }, { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 279, "End": 447 }, { "InterPro-ID": "IPR024914", "InterPro-Name": "tRNA_acetyltr_TmcA", "InterPro-Type": "FAMILY", "Beg": 36, "End": 805 }, { "InterPro-ID": "IPR007807", "InterPro-Name": "NAT10/TcmA_helicase", "InterPro-Type": "DOMAIN", "Beg": 283, "End": 457 }, { "InterPro-ID": "IPR000182", "InterPro-Name": "GNAT_dom", "InterPro-Type": "DOMAIN", "Beg": 469, "End": 664 }, { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 223, "End": 396 }, { "InterPro-ID": "IPR016181", "InterPro-Name": "Acyl_CoA_acyltransferase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 489, "End": 646 }, { "InterPro-ID": "IPR000182", "InterPro-Name": "GNAT_dom", "InterPro-Type": "DOMAIN", "Beg": 498, "End": 610 }, { "InterPro-ID": "IPR032672", "InterPro-Name": "TmcA/NAT10/Kre33", "InterPro-Type": "FAMILY", "Beg": 21, "End": 609 } ], "response#1": "MTVKVKFPKDIREYARKEKVKDSLIKLTETALAEAISKFHRRMIVLQGDTLNKAKLAGILAGGAARILSEYIPEMLERKLRDTEQIEVLYATDALGEDTYGRKRFEEFRKHFSLLAPTAELTSVTFKHSRDILGRTFDILVIDLSYDYSPNDLGRIIETVRGGGLIFVLTNPFEKWKDMWTGFHKSLVTPPYTIEDVKKRFNRRLIRKFTEHKGIYIVNTDRMSIERKPGKYRSQATLPEREKVEIPKNIRFPRELYELCLTRGQVEVLKTLEELIEKEGMVVLTADRGRGKSVSIGIASVGLAVSSKKKRFRIVVTAPEPENVQSLMKFAKKSLEVLGYKTKVITDNGLIKEVYAKGIGIRYYPPTKGYRQRAELYIVDEAAGIHVPILHRYLEKERVVFSSTIHGYEGAGRGFSVKFLKKAKEKREYKEVHLSTPIRYAEGDPIEKWLFDVLLLDAEPVELTEEDYELIRKMEVYLEEPDLDDWFENDREDLRHFVGIYVLAHYRNRPSDVALLADAPHHEARVLRLKNGKIVTAIQIAKEGGIPKAVIDKMAKGYKPPGNIIPDMMVKHHYAKEFARLKGYRVVRIATHPDAMDMGLGSKALELLIKEAEEKGLDWVGSGFGASPELIRFWVRNGFAVVHLSPTRNPVSGEYTAIVIKPISEKAKEIVKKANEEFRIRLTEWLGDTHRDLEPEIARWLFESPFGEAVNYPIYLTKTQKRRLEMFIKRILTYDTVVDAVKPLVKLYFLDGWMRPYLDERQIMLLIHRVLQAHDWKETAKLLNRTEMYTMVELRDIVRGLWYYYKHLIKDEEGEK", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more TmcA_N, NAT10/TcmA_helicase, GNAT_dom, GNAT_dom that are essential for its biological function; 2. The protein should belong to tRNA_acetyltr_TmcA, TmcA/NAT10/Kre33 that shares evolutionary origin and functional similarity; 3. The protein should be classified within P-loop_NTPase, P-loop_NTPase, Acyl_CoA_acyltransferase sharing conserved structural features. The designed protein sequence is ", "reference": "MTVKVKFPKDIREYARKEKVKDSLIKLTETALAEAISKFHRRMIVLQGDTLNKAKLAGILAGGAARILSEYIPEMLERKLRDTEQIEVLYATDALGEDTYGRKRFEEFRKHFSLLAPTAELTSVTFKHSRDILGRTFDILVIDLSYDYSPNDLGRIIETVRGGGLIFVLTNPFEKWKDMWTGFHKSLVTPPYTIEDVKKRFNRRLIRKFTEHKGIYIVNTDRMSIERKPGKYRSQATLPEREKVEIPKNIRFPRELYELCLTRGQVEVLKTLEELIEKEGMVVLTADRGRGKSVSIGIASVGLAVSSKKKRFRIVVTAPEPENVQSLMKFAKKSLEVLGYKTKVITDNGLIKEVYAKGIGIRYYPPTKGYRQRAELYIVDEAAGIHVPILHRYLEKERVVFSSTIHGYEGAGRGFSVKFLKKAKEKREYKEVHLSTPIRYAEGDPIEKWLFDVLLLDAEPVELTEEDYELIRKMEVYLEEPDLDDWFENDREDLRHFVGIYVLAHYRNRPSDVALLADAPHHEARVLRLKNGKIVTAIQIAKEGGIPKAVIDKMAKGYKPPGNIIPDMMVKHHYAKEFARLKGYRVVRIATHPDAMDMGLGSKALELLIKEAEEKGLDWVGSGFGASPELIRFWVRNGFAVVHLSPTRNPVSGEYTAIVIKPISEKAKEIVKKANEEFRIRLTEWLGDTHRDLEPEIARWLFESPFGEAVNYPIYLTKTQKRRLEMFIKRILTYDTVVDAVKPLVKLYFLDGWMRPYLDERQIMLLIHRVLQAHDWKETAKLLNRTEMYTMVELRDIVRGLWYYYKHLIKDEEGEK" }, { "InterPro": [ { "InterPro-ID": "IPR035892", "InterPro-Name": "C2_domain_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 33, "End": 163 }, { "InterPro-ID": "IPR035892", "InterPro-Name": "C2_domain_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 221, "End": 320 }, { "InterPro-ID": "IPR012968", "InterPro-Name": "FerIin_dom", "InterPro-Type": "DOMAIN", "Beg": 123, "End": 185 }, { "InterPro-ID": "IPR000008", "InterPro-Name": "C2_dom", "InterPro-Type": "DOMAIN", "Beg": 224, "End": 303 }, { "InterPro-ID": "IPR000008", "InterPro-Name": "C2_dom", "InterPro-Type": "DOMAIN", "Beg": 35, "End": 136 }, { "InterPro-ID": "IPR000008", "InterPro-Name": "C2_dom", "InterPro-Type": "DOMAIN", "Beg": 1325, "End": 1380 }, { "InterPro-ID": "IPR000008", "InterPro-Name": "C2_dom", "InterPro-Type": "DOMAIN", "Beg": 593, "End": 662 }, { "InterPro-ID": "IPR000008", "InterPro-Name": "C2_dom", "InterPro-Type": "DOMAIN", "Beg": 1500, "End": 1587 }, { "InterPro-ID": "IPR035892", "InterPro-Name": "C2_domain_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 17, "End": 162 }, { "InterPro-ID": "IPR000008", "InterPro-Name": "C2_dom", "InterPro-Type": "DOMAIN", "Beg": 1466, "End": 1595 }, { "InterPro-ID": "IPR035892", "InterPro-Name": "C2_domain_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1485, "End": 1656 }, { "InterPro-ID": "IPR035892", "InterPro-Name": "C2_domain_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1325, "End": 1381 }, { "InterPro-ID": "IPR035892", "InterPro-Name": "C2_domain_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 213, "End": 347 }, { "InterPro-ID": "IPR037721", "InterPro-Name": "Ferlin", "InterPro-Type": "FAMILY", "Beg": 430, "End": 1700 }, { "InterPro-ID": "IPR035892", "InterPro-Name": "C2_domain_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1473, "End": 1587 }, { "InterPro-ID": "IPR000008", "InterPro-Name": "C2_dom", "InterPro-Type": "DOMAIN", "Beg": 207, "End": 332 }, { "InterPro-ID": "IPR000008", "InterPro-Name": "C2_dom", "InterPro-Type": "DOMAIN", "Beg": 18, "End": 141 }, { "InterPro-ID": "IPR000008", "InterPro-Name": "C2_dom", "InterPro-Type": "DOMAIN", "Beg": 574, "End": 676 }, { "InterPro-ID": "IPR000008", "InterPro-Name": "C2_dom", "InterPro-Type": "DOMAIN", "Beg": 1270, "End": 1385 }, { "InterPro-ID": "IPR000008", "InterPro-Name": "C2_dom", "InterPro-Type": "DOMAIN", "Beg": 35, "End": 137 }, { "InterPro-ID": "IPR000008", "InterPro-Name": "C2_dom", "InterPro-Type": "DOMAIN", "Beg": 224, "End": 343 }, { "InterPro-ID": "IPR000008", "InterPro-Name": "C2_dom", "InterPro-Type": "DOMAIN", "Beg": 1484, "End": 1594 } ], "response#1": "MAQIASGVNEIKSNLGDIRKLINQNAQYDQKKEYQVQVTIIEARGLIAKDADGSDPYVKIFVGKLPPQVTNTKSNASTVVFNQSFTFKDLFLNQIELENQEITLQVIDQNQFATNPLIGQQSIGLSTLYRSNNHEFFKTWLTLIHPDQGIEPQGYLLVSCYIIGTEDRPPVHDINEAKEDDDDGCSFLNIPDEELNDEQRKKKAIWKQPVVPINMPLNKREQYQLLVSIVKGEDLPILTGSTCDSFIACRVGSNVLRTMTVKNSQKPNFQTKMVFPVFFPVYNDKIVIRVWDSRTLRSDNFIAAIPEKPNENDWFNINTLHSRGGTMSFRWFHLYGVPLPERPEGMIDEVVKKLTKQVEGTMYMGRILLSLSLSPNEKAELGLQSLGGYKEPPILKYIIRCDTFELQSSFDCGQYIMIEINFGGQVIRSNLCQKRVDSHEKQKNNQQSSRTRELNQYIWKDSKSQIKDELQIDIPFDQSQQPDVIVSLYSVTPNKKTLDYDVGDMKRQAYIRIKPTSRELEHEQPKWYQLKPVKYKTIQEVHSHLLMNVELKTEMVAKQKTRHPIKRSLKQMYQFKGYLWGGYDLLPSHHSDDTCIKAQLQIGTRIIDVVTGRKGKNVIWNHSLEFLIELDEKLEFSSNILVSFYNKKSSDEEFIGQIAIKAVACEVKIDNKQINIPPPKPKYQFYHIVQEGKSNGRILAAFQLQRSEKTFNQNNDVNEPKYDKILKDQDFKYVQVKFPLIGVRNLPEGIRDPEFVFRIPQPDLKFVITLEERKQRKELTRNYYYEKIITLKNNEEEQEQAEQKKTIGGKIFTMIAEQQKVALKNINFCTILENDISECLKIPVDLQFTPILELEIRDRAAAIKTVRYHSSISLIDYIPWGDVGTKNAKIEFFEIGKLNLMLLQDEDQDAVQNQFNDDDEGDNEDEQDSRENDFDDNRDANLIFTEQFREEVDQQNQNSDDKRRLLSNKNLDKLDGDDQPQSLKNLQNLDSLSKADQKSQFDLKSESKSRATGKTKTSKKSTSSTARKLLLQQKLFESTQTFFNAEFNPSVEFTKSLIDEANFKLEREQKIQKLADLVFELKKMKKKDEGREKQLLREIEDLKNYLVKENIFLEQGDDGAQENFDYGREIVRVPLQDQLEKGLPYKKFRLYMYGNNTHDIGIPTAAVIKAHLKVLEHDIEIIKQRKTQIRETLKNKSNRSSMSLSMRSSIQSNTFKSSRKTSRSQKLGENKPLVSYECEGDDQRFPFDIFKKTFLEFFQKQFELKTRVYLLRCTNISAQASKIEAYHLLAGEAAVCSASSYPWVIVGDGENRGKNIIKNIKDDANIAVDTLNPEFFKMYELDATLPEDWNLVVKIMNKGTAIDALIGQFEIDLEDRVLGQKELRRRIAYQTYIEYFREKCEQYKYNYEIGDKKKNYEIKINELITKIEALDRNLKLPVEYLELKHPEKNTCQGTIEFFLEPFPFDVARIIPPSTIEKPQPMEFEIRLIIWETFDIPISNPIQKSTVDIFLTVSLDSTANIKGEEIVKETDVHFGSENGNGVFNYRMVFPLVIPCSFPRLRLQVSDFSTVGSNESLGETVITLRKALKKLKEGIVFQMPTTKFKFEHPNYPGQDRGCVSISMKIINKQAAESDPVGEGQNEPNKDPILEKPKEGRNVGDFLKGTALDFSAWSFFGLTALKYFAGIFVSIVTMMILFVKPGILVN", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more FerIin_dom, C2_dom, C2_dom, C2_dom, C2_dom, C2_dom, C2_dom, C2_dom, C2_dom, C2_dom, C2_dom, C2_dom, C2_dom, C2_dom that are essential for its biological function; 2. The protein should belong to Ferlin that shares evolutionary origin and functional similarity; 3. The protein should be classified within C2_domain_sf, C2_domain_sf, C2_domain_sf, C2_domain_sf, C2_domain_sf, C2_domain_sf, C2_domain_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MAQIASGVNEIKSNLGDIRKLINQNAQYDQKKEYQVQVTIIEARGLIAKDADGSDPYVKIFVGKLPPQVTNTKSNASTVVFNQSFTFKDLFLNQIELENQEITLQVIDQNQFATNPLIGQQSIGLSTLYRSNNHEFFKTWLTLIHPDQGIEPQGYLLVSCYIIGTEDRPPVHDINEAKEDDDDGCSFLNIPDEELNDEQRKKKAIWKQPVVPINMPLNKREQYQLLVSIVKGEDLPILTGSTCDSFIACRVGSNVLRTMTVKNSQKPNFQTKMVFPVFFPVYNDKIVIRVWDSRTLRSDNFIAAIPEKPNENDWFNINTLHSRGGTMSFRWFHLYGVPLPERPEGMIDEVVKKLTKQVEGTMYMGRILLSLSLSPNEKAELGLQSLGGYKEPPILKYIIRCDTFELQSSFDCGQYIMIEINFGGQVIRSNLCQKRVDSHEKQKNNQQSSRTRELNQYIWKDSKSQIKDELQIDIPFDQSQQPDVIVSLYSVTPNKKTLDYDVGDMKRQAYIRIKPTSRELEHEQPKWYQLKPVKYKTIQEVHSHLLMNVELKTEMVAKQKTRHPIKRSLKQMYQFKGYLWGGYDLLPSHHSDDTCIKAQLQIGTRIIDVVTGRKGKNVIWNHSLEFLIELDEKLEFSSNILVSFYNKKSSDEEFIGQIAIKAVACEVKIDNKQINIPPPKPKYQFYHIVQEGKSNGRILAAFQLQRSEKTFNQNNDVNEPKYDKILKDQDFKYVQVKFPLIGVRNLPEGIRDPEFVFRIPQPDLKFVITLEERKQRKELTRNYYYEKIITLKNNEEEQEQAEQKKTIGGKIFTMIAEQQKVALKNINFCTILENDISECLKIPVDLQFTPILELEIRDRAAAIKTVRYHSSISLIDYIPWGDVGTKNAKIEFFEIGKLNLMLLQDEDQDAVQNQFNDDDEGDNEDEQDSRENDFDDNRDANLIFTEQFREEVDQQNQNSDDKRRLLSNKNLDKLDGDDQPQSLKNLQNLDSLSKADQKSQFDLKSESKSRATGKTKTSKKSTSSTARKLLLQQKLFESTQTFFNAEFNPSVEFTKSLIDEANFKLEREQKIQKLADLVFELKKMKKKDEGREKQLLREIEDLKNYLVKENIFLEQGDDGAQENFDYGREIVRVPLQDQLEKGLPYKKFRLYMYGNNTHDIGIPTAAVIKAHLKVLEHDIEIIKQRKTQIRETLKNKSNRSSMSLSMRSSIQSNTFKSSRKTSRSQKLGENKPLVSYECEGDDQRFPFDIFKKTFLEFFQKQFELKTRVYLLRCTNISAQASKIEAYHLLAGEAAVCSASSYPWVIVGDGENRGKNIIKNIKDDANIAVDTLNPEFFKMYELDATLPEDWNLVVKIMNKGTAIDALIGQFEIDLEDRVLGQKELRRRIAYQTYIEYFREKCEQYKYNYEIGDKKKNYEIKINELITKIEALDRNLKLPVEYLELKHPEKNTCQGTIEFFLEPFPFDVARIIPPSTIEKPQPMEFEIRLIIWETFDIPISNPIQKSTVDIFLTVSLDSTANIKGEEIVKETDVHFGSENGNGVFNYRMVFPLVIPCSFPRLRLQVSDFSTVGSNESLGETVITLRKALKKLKEGIVFQMPTTKFKFEHPNYPGQDRGCVSISMKIINKQAAESDPVGEGQNEPNKDPILEKPKEGRNVGDFLKGTALDFSAWSFFGLTALKYFAGIFVSIVTMMILFVKPGILVN" }, { "InterPro": [ { "InterPro-ID": "IPR001137", "InterPro-Name": "Glyco_hydro_11", "InterPro-Type": "FAMILY", "Beg": 158, "End": 163 }, { "InterPro-ID": "IPR001137", "InterPro-Name": "Glyco_hydro_11", "InterPro-Type": "FAMILY", "Beg": 138, "End": 144 }, { "InterPro-ID": "IPR001137", "InterPro-Name": "Glyco_hydro_11", "InterPro-Type": "FAMILY", "Beg": 110, "End": 120 }, { "InterPro-ID": "IPR001137", "InterPro-Name": "Glyco_hydro_11", "InterPro-Type": "FAMILY", "Beg": 163, "End": 172 }, { "InterPro-ID": "IPR001137", "InterPro-Name": "Glyco_hydro_11", "InterPro-Type": "FAMILY", "Beg": 100, "End": 109 }, { "InterPro-ID": "IPR033119", "InterPro-Name": "GH11_AS_2", "InterPro-Type": "ACTIVE_SITE", "Beg": 202, "End": 213 }, { "InterPro-ID": "IPR013319", "InterPro-Name": "GH11/12", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 31, "End": 220 }, { "InterPro-ID": "IPR033123", "InterPro-Name": "GH11_dom", "InterPro-Type": "DOMAIN", "Beg": 28, "End": 218 }, { "InterPro-ID": "IPR013320", "InterPro-Name": "ConA-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 31, "End": 217 }, { "InterPro-ID": "IPR001137", "InterPro-Name": "Glyco_hydro_11", "InterPro-Type": "FAMILY", "Beg": 1, "End": 218 }, { "InterPro-ID": "IPR033123", "InterPro-Name": "GH11_dom", "InterPro-Type": "DOMAIN", "Beg": 37, "End": 215 }, { "InterPro-ID": "IPR018208", "InterPro-Name": "GH11_AS_1", "InterPro-Type": "ACTIVE_SITE", "Beg": 110, "End": 120 } ], "response#1": "MVSFTTLLTAVATAVSAVTASPLEALKRGIQPGTGVHDGYFYSFWTDGRGYVDFNNGPRGSYRVSWSNVNNWVGGKGWNPGPPRRIAYNGTWNNWNVNSYLALYGWTTNPLVEYYIVEAYGSYNPSSGAARLGTIEDDGGVYDIYRTRRINQPSIIGTASFDQYWSVRRQKRVGGTIDTGKHFDEWRRQGNLQLGAWNYMIMATEGYQSSGSAEIEVRSLD", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more GH11_dom, GH11_dom that are essential for its biological function; 2. The protein should belong to Glyco_hydro_11, Glyco_hydro_11, Glyco_hydro_11, Glyco_hydro_11, Glyco_hydro_11, Glyco_hydro_11 that shares evolutionary origin and functional similarity; 3. The protein should be classified within GH11/12, ConA-like_dom_sf sharing conserved structural features; 4. The protein must have GH11_AS_2, GH11_AS_1 that is conserved among related catalytic enzymes. The designed protein sequence is ", "reference": "MVSFTTLLTAVATAVSAVTASPLEALKRGIQPGTGVHDGYFYSFWTDGRGYVDFNNGPRGSYRVSWSNVNNWVGGKGWNPGPPRRIAYNGTWNNWNVNSYLALYGWTTNPLVEYYIVEAYGSYNPSSGAARLGTIEDDGGVYDIYRTRRINQPSIIGTASFDQYWSVRRQKRVGGTIDTGKHFDEWRRQGNLQLGAWNYMIMATEGYQSSGSAEIEVRSLD" }, { "InterPro": [ { "InterPro-ID": "IPR006710", "InterPro-Name": "Glyco_hydro_43", "InterPro-Type": "FAMILY", "Beg": 65, "End": 320 }, { "InterPro-ID": "IPR052176", "InterPro-Name": "Glycosyl_Hydrlase_43_Enz", "InterPro-Type": "FAMILY", "Beg": 3, "End": 326 }, { "InterPro-ID": "IPR023296", "InterPro-Name": "Glyco_hydro_beta-prop_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 3, "End": 325 }, { "InterPro-ID": "IPR023296", "InterPro-Name": "Glyco_hydro_beta-prop_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1, "End": 326 } ], "response#1": "MAPLITNIYTADPSAHVFNGKLYIYPSHDRETDIQFNDNGDQYDMADYHVFSLDSLDPPSEVTDHGVVLKVEDIPWVSKQLWAPDAATKDGKYYLYFPARDKEGIFRIGVAVSDKPEGPFTPDPEPIKGSYSIDPAVFVDDDGSAYMYFGGLWGGQLQCYQKGNNIFDAEWSGPKEPSGSGAKALGPRVAKLTDDMRQFAEEVREIVILAPETGEPLAADDHDRRFFEAAWMHKYNGKYYFSYSTGDTHYLVYAVGDSPYGPFTYGGRILEPVLGWTTHHSIVEFQGRWWLFHHDCELSKGVDHLRSVKVKEIWYDKDGKIVTEKPE", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Glyco_hydro_43, Glycosyl_Hydrlase_43_Enz that shares evolutionary origin and functional similarity; 2. The protein should be classified within Glyco_hydro_beta-prop_sf, Glyco_hydro_beta-prop_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MAPLITNIYTADPSAHVFNGKLYIYPSHDRETDIQFNDNGDQYDMADYHVFSLDSLDPPSEVTDHGVVLKVEDIPWVSKQLWAPDAATKDGKYYLYFPARDKEGIFRIGVAVSDKPEGPFTPDPEPIKGSYSIDPAVFVDDDGSAYMYFGGLWGGQLQCYQKGNNIFDAEWSGPKEPSGSGAKALGPRVAKLTDDMRQFAEEVREIVILAPETGEPLAADDHDRRFFEAAWMHKYNGKYYFSYSTGDTHYLVYAVGDSPYGPFTYGGRILEPVLGWTTHHSIVEFQGRWWLFHHDCELSKGVDHLRSVKVKEIWYDKDGKIVTEKPE" }, { "InterPro": [ { "InterPro-ID": "IPR051134", "InterPro-Name": "PPP_phosphatase", "InterPro-Type": "FAMILY", "Beg": 45, "End": 473 }, { "InterPro-ID": "IPR006186", "InterPro-Name": "Ser/Thr-sp_prot-phosphatase", "InterPro-Type": "DOMAIN", "Beg": 279, "End": 284 }, { "InterPro-ID": "IPR006186", "InterPro-Name": "Ser/Thr-sp_prot-phosphatase", "InterPro-Type": "DOMAIN", "Beg": 183, "End": 460 }, { "InterPro-ID": "IPR029052", "InterPro-Name": "Metallo-depent_PP-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 133, "End": 478 }, { "InterPro-ID": "IPR013235", "InterPro-Name": "PPP_dom", "InterPro-Type": "DOMAIN", "Beg": 117, "End": 207 }, { "InterPro-ID": "IPR011990", "InterPro-Name": "TPR-like_helical_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 7, "End": 132 }, { "InterPro-ID": "IPR011990", "InterPro-Name": "TPR-like_helical_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 6, "End": 136 }, { "InterPro-ID": "IPR041753", "InterPro-Name": "PP5_C", "InterPro-Type": "DOMAIN", "Beg": 156, "End": 471 }, { "InterPro-ID": "IPR006186", "InterPro-Name": "Ser/Thr-sp_prot-phosphatase", "InterPro-Type": "DOMAIN", "Beg": 215, "End": 242 }, { "InterPro-ID": "IPR006186", "InterPro-Name": "Ser/Thr-sp_prot-phosphatase", "InterPro-Type": "DOMAIN", "Beg": 422, "End": 438 }, { "InterPro-ID": "IPR006186", "InterPro-Name": "Ser/Thr-sp_prot-phosphatase", "InterPro-Type": "DOMAIN", "Beg": 312, "End": 338 }, { "InterPro-ID": "IPR006186", "InterPro-Name": "Ser/Thr-sp_prot-phosphatase", "InterPro-Type": "DOMAIN", "Beg": 400, "End": 420 }, { "InterPro-ID": "IPR006186", "InterPro-Name": "Ser/Thr-sp_prot-phosphatase", "InterPro-Type": "DOMAIN", "Beg": 278, "End": 302 }, { "InterPro-ID": "IPR006186", "InterPro-Name": "Ser/Thr-sp_prot-phosphatase", "InterPro-Type": "DOMAIN", "Beg": 344, "End": 371 }, { "InterPro-ID": "IPR006186", "InterPro-Name": "Ser/Thr-sp_prot-phosphatase", "InterPro-Type": "DOMAIN", "Beg": 245, "End": 272 }, { "InterPro-ID": "IPR004843", "InterPro-Name": "Calcineurin-like_PHP_ApaH", "InterPro-Type": "DOMAIN", "Beg": 215, "End": 411 }, { "InterPro-ID": "IPR019734", "InterPro-Name": "TPR_rpt", "InterPro-Type": "REPEAT", "Beg": 43, "End": 76 }, { "InterPro-ID": "IPR019734", "InterPro-Name": "TPR_rpt", "InterPro-Type": "REPEAT", "Beg": 77, "End": 110 }, { "InterPro-ID": "IPR019734", "InterPro-Name": "TPR_rpt", "InterPro-Type": "REPEAT", "Beg": 9, "End": 42 }, { "InterPro-ID": "IPR029052", "InterPro-Name": "Metallo-depent_PP-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 148, "End": 471 } ], "response#1": "MASSDLEAATALKVQGNKAFGQHEWPTAVDFYTQAIAKYDREPSFFSNRAQAHIKLEAYGFAIADATKALELDPAYTKAYWRRALANTAILNYKDALRDFKVVAKREPNNRDAKVKLADCEKLVRRMEFEKAIEVGDPPSAFEDLDIDAIAVDDSYDGVRLEKEMTQEFIDDMIERFKNGKKIHRKYAFQIVKAVKDIVYAEPTMVEIGVDQGTKLTVCGDTHGQFFDLLEIFRLNGYPSEKHAYLFNGDFVDRGSWSTEIALLLYAYKWLRPNGIFLNRGNHETDDMNKVYGFEGECKAKYNERMFKVFSESFSALPLATLIGNKYLVLHGGLFSDDNTSLDDIRKLDRHNQRQPGQQGLMMEMLWTDPQTEPGRGPSKRGVGLQFGPDVTKRFCEKNGLEAIIRSHEVRMEGYEVEHDGRCITVFSAPKYCDTTENKGAFINVGPELKLDFQVFEAVPHPDIKPMAYAQNSIMSMM", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Ser/Thr-sp_prot-phosphatase, Ser/Thr-sp_prot-phosphatase, PPP_dom, PP5_C, Ser/Thr-sp_prot-phosphatase, Ser/Thr-sp_prot-phosphatase, Ser/Thr-sp_prot-phosphatase, Ser/Thr-sp_prot-phosphatase, Ser/Thr-sp_prot-phosphatase, Ser/Thr-sp_prot-phosphatase, Ser/Thr-sp_prot-phosphatase, Calcineurin-like_PHP_ApaH that are essential for its biological function; 2. The protein should belong to PPP_phosphatase that shares evolutionary origin and functional similarity; 3. The protein should be classified within Metallo-depent_PP-like, TPR-like_helical_dom_sf, TPR-like_helical_dom_sf, Metallo-depent_PP-like sharing conserved structural features; 4. The protein should include one or more TPR_rpt, TPR_rpt, TPR_rpt that provide structural or functional support. The designed protein sequence is ", "reference": "MASSDLEAATALKVQGNKAFGQHEWPTAVDFYTQAIAKYDREPSFFSNRAQAHIKLEAYGFAIADATKALELDPAYTKAYWRRALANTAILNYKDALRDFKVVAKREPNNRDAKVKLADCEKLVRRMEFEKAIEVGDPPSAFEDLDIDAIAVDDSYDGVRLEKEMTQEFIDDMIERFKNGKKIHRKYAFQIVKAVKDIVYAEPTMVEIGVDQGTKLTVCGDTHGQFFDLLEIFRLNGYPSEKHAYLFNGDFVDRGSWSTEIALLLYAYKWLRPNGIFLNRGNHETDDMNKVYGFEGECKAKYNERMFKVFSESFSALPLATLIGNKYLVLHGGLFSDDNTSLDDIRKLDRHNQRQPGQQGLMMEMLWTDPQTEPGRGPSKRGVGLQFGPDVTKRFCEKNGLEAIIRSHEVRMEGYEVEHDGRCITVFSAPKYCDTTENKGAFINVGPELKLDFQVFEAVPHPDIKPMAYAQNSIMSMM" }, { "InterPro": [ { "InterPro-ID": "IPR013159", "InterPro-Name": "DnaA_C", "InterPro-Type": "DOMAIN", "Beg": 387, "End": 476 }, { "InterPro-ID": "IPR001957", "InterPro-Name": "Chromosome_initiator_DnaA", "InterPro-Type": "FAMILY", "Beg": 29, "End": 476 }, { "InterPro-ID": "IPR013317", "InterPro-Name": "DnaA_dom", "InterPro-Type": "DOMAIN", "Beg": 145, "End": 305 }, { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 144, "End": 357 }, { "InterPro-ID": "IPR024633", "InterPro-Name": "DnaA_N_dom", "InterPro-Type": "DOMAIN", "Beg": 27, "End": 88 }, { "InterPro-ID": "IPR001957", "InterPro-Name": "Chromosome_initiator_DnaA", "InterPro-Type": "FAMILY", "Beg": 26, "End": 477 }, { "InterPro-ID": "IPR010921", "InterPro-Name": "Trp_repressor/repl_initiator", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 378, "End": 478 }, { "InterPro-ID": "IPR010921", "InterPro-Name": "Trp_repressor/repl_initiator", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 379, "End": 476 }, { "InterPro-ID": "IPR038454", "InterPro-Name": "DnaA_N_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 27, "End": 122 }, { "InterPro-ID": "IPR003593", "InterPro-Name": "AAA+_ATPase", "InterPro-Type": "DOMAIN", "Beg": 177, "End": 310 }, { "InterPro-ID": "IPR013159", "InterPro-Name": "DnaA_C", "InterPro-Type": "DOMAIN", "Beg": 387, "End": 455 }, { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 143, "End": 310 }, { "InterPro-ID": "IPR013159", "InterPro-Name": "DnaA_C", "InterPro-Type": "DOMAIN", "Beg": 386, "End": 455 }, { "InterPro-ID": "IPR018312", "InterPro-Name": "Chromosome_initiator_DnaA_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 436, "End": 455 }, { "InterPro-ID": "IPR020591", "InterPro-Name": "Chromosome_initiator_DnaA-like", "InterPro-Type": "FAMILY", "Beg": 276, "End": 303 }, { "InterPro-ID": "IPR020591", "InterPro-Name": "Chromosome_initiator_DnaA-like", "InterPro-Type": "FAMILY", "Beg": 436, "End": 455 }, { "InterPro-ID": "IPR020591", "InterPro-Name": "Chromosome_initiator_DnaA-like", "InterPro-Type": "FAMILY", "Beg": 242, "End": 256 }, { "InterPro-ID": "IPR020591", "InterPro-Name": "Chromosome_initiator_DnaA-like", "InterPro-Type": "FAMILY", "Beg": 210, "End": 224 }, { "InterPro-ID": "IPR020591", "InterPro-Name": "Chromosome_initiator_DnaA-like", "InterPro-Type": "FAMILY", "Beg": 178, "End": 198 } ], "response#1": "MRRGKKVGGIVLIPYSAAIAVEQSLEHLWEQILERLQHQLSRPTFETWIKTATAEAFDGKVLRLSTPNPFARNWLQKYYLRTIADVAAEILGHGIELQIGVLSDTSAEPESGAELWPAISPPPAVEVVKPPTTTAGRPPLRSSDLNPKYVFSRFVVGANNRMAHAASLAIAEYPGREYNPLFLCGGVGLGKTHLMQAIGHYRLEIDPDAKIFYVSTEQFTNDLIAAIRRDSMQSFREHYRAADVIMVDDIQFIEGKEYTQEEFFYTFNSLHEAGKQIVLASDRPPSQIPRLQERLISRFSMGLIADIQPPDFETRVAILQKKSEFENMPLPRDVIEYIAARYTSNIRELEGALTRAVAYASISGLALTLANIAPVLTPPTEKMELSPEMILQTVAETFDVSIEDLRGNSRRREVSLARQVGMYLMRQHTDLSLPKIGEQFGGKDHTTVMYSCEKIGQLRQSDPQMGKQLQEINDQLFVASRG", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more DnaA_C, DnaA_dom, DnaA_N_dom, AAA+_ATPase, DnaA_C, DnaA_C that are essential for its biological function; 2. The protein should belong to Chromosome_initiator_DnaA, Chromosome_initiator_DnaA, Chromosome_initiator_DnaA-like, Chromosome_initiator_DnaA-like, Chromosome_initiator_DnaA-like, Chromosome_initiator_DnaA-like, Chromosome_initiator_DnaA-like that shares evolutionary origin and functional similarity; 3. The protein should be classified within P-loop_NTPase, Trp_repressor/repl_initiator, Trp_repressor/repl_initiator, DnaA_N_sf, P-loop_NTPase sharing conserved structural features; 4. The protein should contain Chromosome_initiator_DnaA_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MRRGKKVGGIVLIPYSAAIAVEQSLEHLWEQILERLQHQLSRPTFETWIKTATAEAFDGKVLRLSTPNPFARNWLQKYYLRTIADVAAEILGHGIELQIGVLSDTSAEPESGAELWPAISPPPAVEVVKPPTTTAGRPPLRSSDLNPKYVFSRFVVGANNRMAHAASLAIAEYPGREYNPLFLCGGVGLGKTHLMQAIGHYRLEIDPDAKIFYVSTEQFTNDLIAAIRRDSMQSFREHYRAADVIMVDDIQFIEGKEYTQEEFFYTFNSLHEAGKQIVLASDRPPSQIPRLQERLISRFSMGLIADIQPPDFETRVAILQKKSEFENMPLPRDVIEYIAARYTSNIRELEGALTRAVAYASISGLALTLANIAPVLTPPTEKMELSPEMILQTVAETFDVSIEDLRGNSRRREVSLARQVGMYLMRQHTDLSLPKIGEQFGGKDHTTVMYSCEKIGQLRQSDPQMGKQLQEINDQLFVASRG" }, { "InterPro": [ { "InterPro-ID": "IPR049574", "InterPro-Name": "CrtA-like", "InterPro-Type": "FAMILY", "Beg": 3, "End": 228 } ], "response#1": "MQTVTLSIFRFNEFEKRLWVLGQMTANKLGMHYLPKAKFWKMFGSGTGQGFTPKPNWHVWSILAVWPDEETARREVAESPIYQRWTKMADESYTVLLQPTSAWGKWDGKEPFEPVKPASDVRPIAALTRATVKFWKAERFWAREPAISHMIGRNKDVVFKIGVGEVPFVQQVTFSIWPDARSMEEFARGAGGPHGEAIKAVRAENWFKEELYARFQILGTIGKWEGKDPVGEALTARPSEAPKPAPAPAAAQPAPAAEAPKPAPAPVAEKPALAVEMPKPAEPPKPVVEAPKPASAPVASKPMPQGGKPNFKGKPGKGGRKENA", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to CrtA-like that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MQTVTLSIFRFNEFEKRLWVLGQMTANKLGMHYLPKAKFWKMFGSGTGQGFTPKPNWHVWSILAVWPDEETARREVAESPIYQRWTKMADESYTVLLQPTSAWGKWDGKEPFEPVKPASDVRPIAALTRATVKFWKAERFWAREPAISHMIGRNKDVVFKIGVGEVPFVQQVTFSIWPDARSMEEFARGAGGPHGEAIKAVRAENWFKEELYARFQILGTIGKWEGKDPVGEALTARPSEAPKPAPAPAAAQPAPAAEAPKPAPAPVAEKPALAVEMPKPAEPPKPVVEAPKPASAPVASKPMPQGGKPNFKGKPGKGGRKENA" }, { "InterPro": [ { "InterPro-ID": "IPR045861", "InterPro-Name": "CorA_cytoplasmic_dom", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 9, "End": 260 }, { "InterPro-ID": "IPR002523", "InterPro-Name": "MgTranspt_CorA/ZnTranspt_ZntB", "InterPro-Type": "FAMILY", "Beg": 41, "End": 328 }, { "InterPro-ID": "IPR045863", "InterPro-Name": "CorA_TM1_TM2", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 267, "End": 329 } ], "response#1": "MQAYESGDERGLIYGYVLNGRGGGRRVGRNQIAVLDLLPEESLWLHWDRGVPEAQAWLRDSAGLSEFACDLLLEEATRPRLLDLGAESLLVFLRGVNLNPGAEPEDMVSLRVFADARRVISLRLRPLKAVADLLEDLEAGKGPKTASEVVYYLAHYLTDRVDTLISGIADQLDAVEELVEADERASPDQHQLRTLRRRSAGLRRYLAPQRDIYSQLARYKLSWFVEDDADYWNELNNRLTRNLEELELIRERISVLQEAESRRITERMNRTMYLLGIITGFFLPMSFVTGLLGINVGGIPGADAPHGFWLACLLIGGVATFQWWVFRRLRWL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to MgTranspt_CorA/ZnTranspt_ZntB that shares evolutionary origin and functional similarity; 2. The protein should be classified within CorA_cytoplasmic_dom, CorA_TM1_TM2 sharing conserved structural features. The designed protein sequence is ", "reference": "MQAYESGDERGLIYGYVLNGRGGGRRVGRNQIAVLDLLPEESLWLHWDRGVPEAQAWLRDSAGLSEFACDLLLEEATRPRLLDLGAESLLVFLRGVNLNPGAEPEDMVSLRVFADARRVISLRLRPLKAVADLLEDLEAGKGPKTASEVVYYLAHYLTDRVDTLISGIADQLDAVEELVEADERASPDQHQLRTLRRRSAGLRRYLAPQRDIYSQLARYKLSWFVEDDADYWNELNNRLTRNLEELELIRERISVLQEAESRRITERMNRTMYLLGIITGFFLPMSFVTGLLGINVGGIPGADAPHGFWLACLLIGGVATFQWWVFRRLRWL" }, { "InterPro": [ { "InterPro-ID": "IPR014030", "InterPro-Name": "Ketoacyl_synth_N", "InterPro-Type": "DOMAIN", "Beg": 12, "End": 269 }, { "InterPro-ID": "IPR036291", "InterPro-Name": "NAD(P)-bd_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1959, "End": 2126 }, { "InterPro-ID": "IPR009081", "InterPro-Name": "PP-bd_ACP", "InterPro-Type": "DOMAIN", "Beg": 2478, "End": 2557 }, { "InterPro-ID": "IPR016039", "InterPro-Name": "Thiolase-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 4, "End": 473 }, { "InterPro-ID": "IPR020807", "InterPro-Name": "PKS_DH", "InterPro-Type": "DOMAIN", "Beg": 949, "End": 1130 }, { "InterPro-ID": "IPR014043", "InterPro-Name": "Acyl_transferase_dom", "InterPro-Type": "DOMAIN", "Beg": 558, "End": 882 }, { "InterPro-ID": "IPR013149", "InterPro-Name": "ADH-like_C", "InterPro-Type": "DOMAIN", "Beg": 1999, "End": 2110 }, { "InterPro-ID": "IPR016039", "InterPro-Name": "Thiolase-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 8, "End": 444 }, { "InterPro-ID": "IPR016036", "InterPro-Name": "Malonyl_transacylase_ACP-bd", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 686, "End": 752 }, { "InterPro-ID": "IPR049900", "InterPro-Name": "PKS_mFAS_DH", "InterPro-Type": "DOMAIN", "Beg": 949, "End": 1258 }, { "InterPro-ID": "IPR050091", "InterPro-Name": "PKS_NRPS_Biosynth_Enz", "InterPro-Type": "FAMILY", "Beg": 13, "End": 2555 }, { "InterPro-ID": "IPR029063", "InterPro-Name": "SAM-dependent_MTases_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1402, "End": 1624 }, { "InterPro-ID": "IPR002364", "InterPro-Name": "Quin_OxRdtase/zeta-crystal_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 1988, "End": 2009 }, { "InterPro-ID": "IPR014043", "InterPro-Name": "Acyl_transferase_dom", "InterPro-Type": "DOMAIN", "Beg": 558, "End": 879 }, { "InterPro-ID": "IPR014031", "InterPro-Name": "Ketoacyl_synth_C", "InterPro-Type": "DOMAIN", "Beg": 278, "End": 395 }, { "InterPro-ID": "IPR020843", "InterPro-Name": "PKS_ER", "InterPro-Type": "DOMAIN", "Beg": 1857, "End": 2174 }, { "InterPro-ID": "IPR049551", "InterPro-Name": "PKS_DH_C", "InterPro-Type": "DOMAIN", "Beg": 1094, "End": 1257 }, { "InterPro-ID": "IPR020841", "InterPro-Name": "PKS_Beta-ketoAc_synthase_dom", "InterPro-Type": "DOMAIN", "Beg": 11, "End": 445 }, { "InterPro-ID": "IPR001227", "InterPro-Name": "Ac_transferase_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 556, "End": 882 }, { "InterPro-ID": "IPR036736", "InterPro-Name": "ACP-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 2485, "End": 2554 }, { "InterPro-ID": "IPR011032", "InterPro-Name": "GroES-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1874, "End": 1988 }, { "InterPro-ID": "IPR013217", "InterPro-Name": "Methyltransf_12", "InterPro-Type": "DOMAIN", "Beg": 1448, "End": 1555 }, { "InterPro-ID": "IPR032821", "InterPro-Name": "PKS_assoc", "InterPro-Type": "DOMAIN", "Beg": 397, "End": 498 }, { "InterPro-ID": "IPR056501", "InterPro-Name": "NAD-bd_HRPKS_sdrA", "InterPro-Type": "DOMAIN", "Beg": 1677, "End": 1815 }, { "InterPro-ID": "IPR036736", "InterPro-Name": "ACP-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 2469, "End": 2562 }, { "InterPro-ID": "IPR029063", "InterPro-Name": "SAM-dependent_MTases_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1311, "End": 1620 }, { "InterPro-ID": "IPR020806", "InterPro-Name": "PKS_PP-bd", "InterPro-Type": "DOMAIN", "Beg": 2487, "End": 2558 }, { "InterPro-ID": "IPR036291", "InterPro-Name": "NAD(P)-bd_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 2194, "End": 2424 }, { "InterPro-ID": "IPR013154", "InterPro-Name": "ADH-like_N", "InterPro-Type": "DOMAIN", "Beg": 1879, "End": 1936 }, { "InterPro-ID": "IPR020841", "InterPro-Name": "PKS_Beta-ketoAc_synthase_dom", "InterPro-Type": "DOMAIN", "Beg": 14, "End": 448 }, { "InterPro-ID": "IPR013968", "InterPro-Name": "PKS_KR", "InterPro-Type": "DOMAIN", "Beg": 2197, "End": 2375 }, { "InterPro-ID": "IPR006162", "InterPro-Name": "Ppantetheine_attach_site", "InterPro-Type": "PTM", "Beg": 2513, "End": 2528 }, { "InterPro-ID": "IPR042104", "InterPro-Name": "PKS_dehydratase_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 935, "End": 1256 }, { "InterPro-ID": "IPR016035", "InterPro-Name": "Acyl_Trfase/lysoPLipase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 554, "End": 865 }, { "InterPro-ID": "IPR009081", "InterPro-Name": "PP-bd_ACP", "InterPro-Type": "DOMAIN", "Beg": 2481, "End": 2558 }, { "InterPro-ID": "IPR049552", "InterPro-Name": "PKS_DH_N", "InterPro-Type": "DOMAIN", "Beg": 949, "End": 1050 } ], "response#1": "MQSAGMHRATAEPIAIVGLSCKFAGEASTPDRLWEMLAAGRSAWSEIPPSRFNLKGAYHPSADRTNTVCFNSLCRGNPTEEKKVHVRGGHFLEQDLGLFDAQFFSFSAETAASMDPQIRLQLESVYEALENAGITLPDVAGSNTAVYAAVFSRDYRDGIIRDEDRLPRFLPTGTGDAMFSNRVSHFFDLRGPSITLDTGCSGGLVALHEGVKSLRTGESDMALISGEGLTDEGRFFSPDGKSYAFDSRANGYGRGEGIATIVIKRLSDAIIAGDPIRAIVRESGLNQDGKTETITTPSEEAQVALMRDCYRRAGLDYADTQYLEAHGTGTSTGDPIECRAIATVFKDSRSSEQPLRIGSVKTNVGHTEAASGLASLIKVVMALEKGKIPPSINFEKPNPKIALDEWNLRVVTTLEDWPAGPGGVRRASINNFGFGGTNAHLIVESQAAQPLPWQADGYGASATNLDSQIFVFSARDKQACVNMVNNLKKYLRQNAATDSPDFLLQRVAYTLGQRRTRFPWVTARPVPVQNGFREAIQALEVNMPVPRRTTGIPRIGMVFTGQGAQWYAMGRELIAAYPVFKASLKETDRHLAALGARWSVIEELNQDIPASRVHDVEYSTPLCVAVQISLVRLLRSWGVKPVAVTSHSSGEIAAAYAVGALGCQDAMAVAYHRALLATRSSLGSKQGAMLVVGMSLEETETYLARIDAQIGIATVACVNSPSSITVSGDQDAVNALEALARNDGIFTHRLKIHTAFHSHHMNPIADLYRSALQGALSPNHDKVESDITFSSPVTGRRITNLSQLSEPDHWVDSLLKPVQFVDAFTDMVLGASGASSANVDLILEVGPHTALGAPIKQILAEPKFAGLDISCLGSLVREVSAVRSMHSLAASLVAEGLPLDLDAVNFPHGRPPSVRALSDLPSYPWNHQTRHWYESRFNKGLRERAQPPHDLLGSLVLGTDPNSPTWRHILKLKDAPWLREHVVQEDILFPGAGFICLAIEAIKMLPELQSKAPQAAAGYRLRDVDLLQGLVIPDNDDGVEIQTSLSEVSDKEMGNRGWKRFEVSSVSADNQWSTHARGLITMEPEDAPDKTITKSRPADLSGYTRRFGPSDLYDMMRERGIYHGPAFQIITDIEQAGNNQRADSSLFIPDTAIPADSPYQTLIHPITLDAAFQTVYAPLLGGKEWDDAIVPRTLGSLWISNSISQAAGHRFKAFAILHHSDARTMRSDIYMADNNSDASPVLMVRNAVFQSVGRSAAPQQVKAQWESEPCTNVVWGPDMSLLSTPMRAQLKQQLSHPPEAEEARLLADLRRACLYFIYDALSSLRPFELRKLPSHHAKYHSWMQVQVSLAAECRLAEDSARWSSDTQEQRQSLIERVGRSSVNGEMVCKLGPHLAAIIRQEKMPLELMMENNMLNHYYQNALKCDRILSQAAHILQNLIHKNPRARILEIGAGTGSFTRYALPKIGTAATGGPLAELYHFTDISPAFFEAAREEFAAWDDIMVFEKLDIEQDPASQGYDMESYDIVVAVQVLHATTSMSKTMSHVRKLMKPGGHLLLVETTHDQLDTEFAFGLLPGWWLSEEPQRALSPSMSVPLWDETLKAAALSGVDFEVRDCESDEWYMMSVITSTAVPAHQLTLNPDSIVFVERKDAPCRQRWLEILRSNFAAAGQSPPVVEFETATAESYKGKWTVFLGEVDKPLLYDLDATGLKNIQTMIKHSRSLLWVTRGGAVKCERPELSLATGFLRSIRHEYAGRRFVTFDLDPHESLWSDTSTADIAKVMTTSFGSAADNAQTPPPYDFEYAVREGVILVPRLFRDSARNQAINPASVCWASPEALPTESFFQSNRTLALKVGVPGLLDTIAFDDDPAALADCTQLPPDLVEIKPRAYGVNFRDVLVAMGQLEERVMGVDCAGVITRVGCQAAAHGYAPGDNVFALVRSGYSSRPRVEWTNAMHIPQGLSFEQAASVPAIFTTVYLCFYKIARLQRGQTVLIHAGAGGVGQTAIQFARHIGAEVYTTVGSAEKRELLIQRYGIPADHIFSSRDASFADGILEATNGRGVDVVLNSLAGPLLQASLNILAPFGHFVEVGKRDIEQNSHLEMRPFSRHITFSSFDLLALSQHDKRSIHSSLIEIRRLLEEGAISPVYPVSTYPLGDIGKVFRLLQVGKHSGKVVLSISPDEQVRVVPQARTAKLRSDASYLLVGGAGGIGRSMAHWLAAHGAKNIIVLSRSAGTSPAVAELVAELQPLGCHVKPISCDASVKADLAAALSSCSAELPPIRGVIQAAMVLQDSVLERMTFEDWQTSLNPKVRASWNVHTQLRDADLDFFVFLSSMSGIYGYTTQSNYSAGNTYEDALAHWRVSQGLPAVSMDLGPVKSVGYVAGVAGVADRMTKLGHFPVTEEQVLRVLETAVLSPFDKQVAMGINQGPGSHWHPVGPSPLGRDARFRSLQYQKSTQRQATNGYSNASTSLASRLSDAKTRQQAEKLVVEAIASKLADIFMIPVAHVDAAKHLSEYGLDSLSAVELRNMLALQAAADVSIFSIMQSESLAALASEVTRKSTHVPASLSVM", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Ketoacyl_synth_N, PP-bd_ACP, PKS_DH, Acyl_transferase_dom, ADH-like_C, PKS_mFAS_DH, Acyl_transferase_dom, Ketoacyl_synth_C, PKS_ER, PKS_DH_C, PKS_Beta-ketoAc_synthase_dom, Methyltransf_12, PKS_assoc, NAD-bd_HRPKS_sdrA, PKS_PP-bd, ADH-like_N, PKS_Beta-ketoAc_synthase_dom, PKS_KR, PP-bd_ACP, PKS_DH_N that are essential for its biological function; 2. The protein should belong to PKS_NRPS_Biosynth_Enz that shares evolutionary origin and functional similarity; 3. The protein should be classified within NAD(P)-bd_dom_sf, Thiolase-like, Thiolase-like, Malonyl_transacylase_ACP-bd, SAM-dependent_MTases_sf, Ac_transferase_dom_sf, ACP-like_sf, GroES-like_sf, ACP-like_sf, SAM-dependent_MTases_sf, NAD(P)-bd_dom_sf, PKS_dehydratase_sf, Acyl_Trfase/lysoPLipase sharing conserved structural features; 4. The protein should contain Quin_OxRdtase/zeta-crystal_CS that is preserved across related proteins; 5. The protein should contain Ppantetheine_attach_site that allow regulation through chemical modifications. The designed protein sequence is ", "reference": "MQSAGMHRATAEPIAIVGLSCKFAGEASTPDRLWEMLAAGRSAWSEIPPSRFNLKGAYHPSADRTNTVCFNSLCRGNPTEEKKVHVRGGHFLEQDLGLFDAQFFSFSAETAASMDPQIRLQLESVYEALENAGITLPDVAGSNTAVYAAVFSRDYRDGIIRDEDRLPRFLPTGTGDAMFSNRVSHFFDLRGPSITLDTGCSGGLVALHEGVKSLRTGESDMALISGEGLTDEGRFFSPDGKSYAFDSRANGYGRGEGIATIVIKRLSDAIIAGDPIRAIVRESGLNQDGKTETITTPSEEAQVALMRDCYRRAGLDYADTQYLEAHGTGTSTGDPIECRAIATVFKDSRSSEQPLRIGSVKTNVGHTEAASGLASLIKVVMALEKGKIPPSINFEKPNPKIALDEWNLRVVTTLEDWPAGPGGVRRASINNFGFGGTNAHLIVESQAAQPLPWQADGYGASATNLDSQIFVFSARDKQACVNMVNNLKKYLRQNAATDSPDFLLQRVAYTLGQRRTRFPWVTARPVPVQNGFREAIQALEVNMPVPRRTTGIPRIGMVFTGQGAQWYAMGRELIAAYPVFKASLKETDRHLAALGARWSVIEELNQDIPASRVHDVEYSTPLCVAVQISLVRLLRSWGVKPVAVTSHSSGEIAAAYAVGALGCQDAMAVAYHRALLATRSSLGSKQGAMLVVGMSLEETETYLARIDAQIGIATVACVNSPSSITVSGDQDAVNALEALARNDGIFTHRLKIHTAFHSHHMNPIADLYRSALQGALSPNHDKVESDITFSSPVTGRRITNLSQLSEPDHWVDSLLKPVQFVDAFTDMVLGASGASSANVDLILEVGPHTALGAPIKQILAEPKFAGLDISCLGSLVREVSAVRSMHSLAASLVAEGLPLDLDAVNFPHGRPPSVRALSDLPSYPWNHQTRHWYESRFNKGLRERAQPPHDLLGSLVLGTDPNSPTWRHILKLKDAPWLREHVVQEDILFPGAGFICLAIEAIKMLPELQSKAPQAAAGYRLRDVDLLQGLVIPDNDDGVEIQTSLSEVSDKEMGNRGWKRFEVSSVSADNQWSTHARGLITMEPEDAPDKTITKSRPADLSGYTRRFGPSDLYDMMRERGIYHGPAFQIITDIEQAGNNQRADSSLFIPDTAIPADSPYQTLIHPITLDAAFQTVYAPLLGGKEWDDAIVPRTLGSLWISNSISQAAGHRFKAFAILHHSDARTMRSDIYMADNNSDASPVLMVRNAVFQSVGRSAAPQQVKAQWESEPCTNVVWGPDMSLLSTPMRAQLKQQLSHPPEAEEARLLADLRRACLYFIYDALSSLRPFELRKLPSHHAKYHSWMQVQVSLAAECRLAEDSARWSSDTQEQRQSLIERVGRSSVNGEMVCKLGPHLAAIIRQEKMPLELMMENNMLNHYYQNALKCDRILSQAAHILQNLIHKNPRARILEIGAGTGSFTRYALPKIGTAATGGPLAELYHFTDISPAFFEAAREEFAAWDDIMVFEKLDIEQDPASQGYDMESYDIVVAVQVLHATTSMSKTMSHVRKLMKPGGHLLLVETTHDQLDTEFAFGLLPGWWLSEEPQRALSPSMSVPLWDETLKAAALSGVDFEVRDCESDEWYMMSVITSTAVPAHQLTLNPDSIVFVERKDAPCRQRWLEILRSNFAAAGQSPPVVEFETATAESYKGKWTVFLGEVDKPLLYDLDATGLKNIQTMIKHSRSLLWVTRGGAVKCERPELSLATGFLRSIRHEYAGRRFVTFDLDPHESLWSDTSTADIAKVMTTSFGSAADNAQTPPPYDFEYAVREGVILVPRLFRDSARNQAINPASVCWASPEALPTESFFQSNRTLALKVGVPGLLDTIAFDDDPAALADCTQLPPDLVEIKPRAYGVNFRDVLVAMGQLEERVMGVDCAGVITRVGCQAAAHGYAPGDNVFALVRSGYSSRPRVEWTNAMHIPQGLSFEQAASVPAIFTTVYLCFYKIARLQRGQTVLIHAGAGGVGQTAIQFARHIGAEVYTTVGSAEKRELLIQRYGIPADHIFSSRDASFADGILEATNGRGVDVVLNSLAGPLLQASLNILAPFGHFVEVGKRDIEQNSHLEMRPFSRHITFSSFDLLALSQHDKRSIHSSLIEIRRLLEEGAISPVYPVSTYPLGDIGKVFRLLQVGKHSGKVVLSISPDEQVRVVPQARTAKLRSDASYLLVGGAGGIGRSMAHWLAAHGAKNIIVLSRSAGTSPAVAELVAELQPLGCHVKPISCDASVKADLAAALSSCSAELPPIRGVIQAAMVLQDSVLERMTFEDWQTSLNPKVRASWNVHTQLRDADLDFFVFLSSMSGIYGYTTQSNYSAGNTYEDALAHWRVSQGLPAVSMDLGPVKSVGYVAGVAGVADRMTKLGHFPVTEEQVLRVLETAVLSPFDKQVAMGINQGPGSHWHPVGPSPLGRDARFRSLQYQKSTQRQATNGYSNASTSLASRLSDAKTRQQAEKLVVEAIASKLADIFMIPVAHVDAAKHLSEYGLDSLSAVELRNMLALQAAADVSIFSIMQSESLAALASEVTRKSTHVPASLSVM" }, { "InterPro": [ { "InterPro-ID": "IPR000552", "InterPro-Name": "Ribosomal_eL44", "InterPro-Type": "FAMILY", "Beg": 2, "End": 92 }, { "InterPro-ID": "IPR000552", "InterPro-Name": "Ribosomal_eL44", "InterPro-Type": "FAMILY", "Beg": 16, "End": 92 }, { "InterPro-ID": "IPR011332", "InterPro-Name": "Ribosomal_zn-bd", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1, "End": 93 }, { "InterPro-ID": "IPR000552", "InterPro-Name": "Ribosomal_eL44", "InterPro-Type": "FAMILY", "Beg": 60, "End": 71 }, { "InterPro-ID": "IPR053708", "InterPro-Name": "Ribosomal_LSU_eL42", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1, "End": 94 }, { "InterPro-ID": "IPR000552", "InterPro-Name": "Ribosomal_eL44", "InterPro-Type": "FAMILY", "Beg": 1, "End": 92 } ], "response#1": "MKYPKQIRTYCPFCKRHTIHKVEKVKKRPRSELSAGQRRFRRKLKGYTGFPRPNPAGREKPVKKLDLRFRCTVCGKAHTRGQGFRVKKFELVEV", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Ribosomal_eL44, Ribosomal_eL44, Ribosomal_eL44, Ribosomal_eL44 that shares evolutionary origin and functional similarity; 2. The protein should be classified within Ribosomal_zn-bd, Ribosomal_LSU_eL42 sharing conserved structural features. The designed protein sequence is ", "reference": "MKYPKQIRTYCPFCKRHTIHKVEKVKKRPRSELSAGQRRFRRKLKGYTGFPRPNPAGREKPVKKLDLRFRCTVCGKAHTRGQGFRVKKFELVEV" }, { "InterPro": [ { "InterPro-ID": "IPR036259", "InterPro-Name": "MFS_trans_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 42, "End": 231 }, { "InterPro-ID": "IPR036259", "InterPro-Name": "MFS_trans_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 50, "End": 443 }, { "InterPro-ID": "IPR039309", "InterPro-Name": "BT1", "InterPro-Type": "FAMILY", "Beg": 52, "End": 453 }, { "InterPro-ID": "IPR039309", "InterPro-Name": "BT1", "InterPro-Type": "FAMILY", "Beg": 44, "End": 445 } ], "response#1": "MIEKSNNPFLSIDPIVERTKSNGEGLPLLSEKTKKGFDFTQIVVYLVGLSDGLTHLASLAIYYLFKDYFRLTPYQVSLILMYPYIPFILKPVIALITDSFSIFGMRRKPYLFLFSLFQSLNFLALAFLNLSVIQASLILFFISLCASFCTTVAEALVVESSMGQTYSQGTNKVTEFIASKAIGSLSVAYFSGYFLEKMPREYIFIATSIFPLIISLSCLFLKEKEYSTNRNIFNQLSDLIKFINTPIFLGPFLYIFVYMSGPDYDDAFFFFCTNKLGFRPSFMGTLRLTYGIASLIGIIIYRVFLKNCSLRKTLIITTLVSFPIYISPIILTEHINKFLGISNELFVLSGGFLIEAITEIQLLPLFILTANICQPGLEASVFATILSVKNLGSLTKKGTSSFITYLMKIDSYNFDNLSLYILTCGFFLLFSLTLVPLLPNEEHIEKLKNKETSKG", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to BT1, BT1 that shares evolutionary origin and functional similarity; 2. The protein should be classified within MFS_trans_sf, MFS_trans_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MIEKSNNPFLSIDPIVERTKSNGEGLPLLSEKTKKGFDFTQIVVYLVGLSDGLTHLASLAIYYLFKDYFRLTPYQVSLILMYPYIPFILKPVIALITDSFSIFGMRRKPYLFLFSLFQSLNFLALAFLNLSVIQASLILFFISLCASFCTTVAEALVVESSMGQTYSQGTNKVTEFIASKAIGSLSVAYFSGYFLEKMPREYIFIATSIFPLIISLSCLFLKEKEYSTNRNIFNQLSDLIKFINTPIFLGPFLYIFVYMSGPDYDDAFFFFCTNKLGFRPSFMGTLRLTYGIASLIGIIIYRVFLKNCSLRKTLIITTLVSFPIYISPIILTEHINKFLGISNELFVLSGGFLIEAITEIQLLPLFILTANICQPGLEASVFATILSVKNLGSLTKKGTSSFITYLMKIDSYNFDNLSLYILTCGFFLLFSLTLVPLLPNEEHIEKLKNKETSKG" }, { "InterPro": [ { "InterPro-ID": "IPR023638", "InterPro-Name": "Ribosomal_eL19_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 7, "End": 26 }, { "InterPro-ID": "IPR039547", "InterPro-Name": "Ribosomal_eL19", "InterPro-Type": "FAMILY", "Beg": 1, "End": 143 }, { "InterPro-ID": "IPR035970", "InterPro-Name": "60S_ribosomal_eL19_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 3, "End": 143 }, { "InterPro-ID": "IPR000196", "InterPro-Name": "Ribosomal_eL19_dom", "InterPro-Type": "DOMAIN", "Beg": 4, "End": 145 }, { "InterPro-ID": "IPR000196", "InterPro-Name": "Ribosomal_eL19_dom", "InterPro-Type": "DOMAIN", "Beg": 3, "End": 146 }, { "InterPro-ID": "IPR000196", "InterPro-Name": "Ribosomal_eL19_dom", "InterPro-Type": "DOMAIN", "Beg": 3, "End": 149 }, { "InterPro-ID": "IPR015972", "InterPro-Name": "Ribosomal_eL19_dom1", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1, "End": 55 } ], "response#1": "MIMLKTQRRIAAELLKCGENRIWIDPERIEDVAAAITREDIKRLIHDGVIKKKPIKGQSRARARAFQEARKKGRHRGPGSKKGKKTARMGKKEVWMMTIRALRKELRKLKAEGKLDAHTYRRLYIRAKGGQFKNKRQLYMFMQEHGILKE", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Ribosomal_eL19_dom, Ribosomal_eL19_dom, Ribosomal_eL19_dom that are essential for its biological function; 2. The protein should belong to Ribosomal_eL19 that shares evolutionary origin and functional similarity; 3. The protein should be classified within 60S_ribosomal_eL19_sf, Ribosomal_eL19_dom1 sharing conserved structural features; 4. The protein should contain Ribosomal_eL19_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MIMLKTQRRIAAELLKCGENRIWIDPERIEDVAAAITREDIKRLIHDGVIKKKPIKGQSRARARAFQEARKKGRHRGPGSKKGKKTARMGKKEVWMMTIRALRKELRKLKAEGKLDAHTYRRLYIRAKGGQFKNKRQLYMFMQEHGILKE" }, { "InterPro": [ { "InterPro-ID": "IPR000725", "InterPro-Name": "Olfact_rcpt", "InterPro-Type": "FAMILY", "Beg": 234, "End": 243 }, { "InterPro-ID": "IPR000725", "InterPro-Name": "Olfact_rcpt", "InterPro-Type": "FAMILY", "Beg": 90, "End": 101 }, { "InterPro-ID": "IPR000725", "InterPro-Name": "Olfact_rcpt", "InterPro-Type": "FAMILY", "Beg": 127, "End": 139 }, { "InterPro-ID": "IPR000725", "InterPro-Name": "Olfact_rcpt", "InterPro-Type": "FAMILY", "Beg": 281, "End": 292 }, { "InterPro-ID": "IPR000725", "InterPro-Name": "Olfact_rcpt", "InterPro-Type": "FAMILY", "Beg": 174, "End": 190 }, { "InterPro-ID": "IPR017452", "InterPro-Name": "GPCR_Rhodpsn_7TM", "InterPro-Type": "DOMAIN", "Beg": 39, "End": 288 }, { "InterPro-ID": "IPR000276", "InterPro-Name": "GPCR_Rhodpsn", "InterPro-Type": "FAMILY", "Beg": 24, "End": 48 }, { "InterPro-ID": "IPR000276", "InterPro-Name": "GPCR_Rhodpsn", "InterPro-Type": "FAMILY", "Beg": 270, "End": 296 }, { "InterPro-ID": "IPR000276", "InterPro-Name": "GPCR_Rhodpsn", "InterPro-Type": "FAMILY", "Beg": 57, "End": 78 }, { "InterPro-ID": "IPR000276", "InterPro-Name": "GPCR_Rhodpsn", "InterPro-Type": "FAMILY", "Beg": 102, "End": 124 }, { "InterPro-ID": "IPR000725", "InterPro-Name": "Olfact_rcpt", "InterPro-Type": "FAMILY", "Beg": 29, "End": 303 }, { "InterPro-ID": "IPR000276", "InterPro-Name": "GPCR_Rhodpsn", "InterPro-Type": "FAMILY", "Beg": 108, "End": 124 } ], "response#1": "MVNFTHVSEFVLLGFQGGPGMQAMLFLIFLILYGIAVVGNLGMIVIIWVDAHLHTPMYAFLQSLSLLDICYSSTIAPRALANSMQEDHTISFGGCAAQFFFLSLFGITEAFLLAAMAYDRFIAICNPLLYSVSMSHQVCVLLISGSYLWGVVNAIAQTTMTFRLPFCGSNEINDFFCDVPPLLSLSCSDTFINQLVLLGLCGSIIVSTFLIVLVSYIYIISTILRIPTMQGCQKAFSTCASHLTGVCLFFGTVFFMYAQPSAIFFMEQSKIVSIFYTMVIPMLNPLIYSLRNKEVKQALRRSMQKLSL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more GPCR_Rhodpsn_7TM that are essential for its biological function; 2. The protein should belong to Olfact_rcpt, Olfact_rcpt, Olfact_rcpt, Olfact_rcpt, Olfact_rcpt, GPCR_Rhodpsn, GPCR_Rhodpsn, GPCR_Rhodpsn, GPCR_Rhodpsn, Olfact_rcpt, GPCR_Rhodpsn that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MVNFTHVSEFVLLGFQGGPGMQAMLFLIFLILYGIAVVGNLGMIVIIWVDAHLHTPMYAFLQSLSLLDICYSSTIAPRALANSMQEDHTISFGGCAAQFFFLSLFGITEAFLLAAMAYDRFIAICNPLLYSVSMSHQVCVLLISGSYLWGVVNAIAQTTMTFRLPFCGSNEINDFFCDVPPLLSLSCSDTFINQLVLLGLCGSIIVSTFLIVLVSYIYIISTILRIPTMQGCQKAFSTCASHLTGVCLFFGTVFFMYAQPSAIFFMEQSKIVSIFYTMVIPMLNPLIYSLRNKEVKQALRRSMQKLSL" }, { "InterPro": [ { "InterPro-ID": "IPR007342", "InterPro-Name": "PsuG", "InterPro-Type": "FAMILY", "Beg": 16, "End": 304 }, { "InterPro-ID": "IPR022830", "InterPro-Name": "Indigdn_synthA-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 6, "End": 309 }, { "InterPro-ID": "IPR022830", "InterPro-Name": "Indigdn_synthA-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 8, "End": 306 }, { "InterPro-ID": "IPR007342", "InterPro-Name": "PsuG", "InterPro-Type": "FAMILY", "Beg": 15, "End": 308 } ], "response#1": "MSKTDFSHDLLRFSDEVKEALHSGKPVVALESTVIAHGLPYPENVATARKIEAAVRAEGAIPATIGIENGRFLIGMSDADLERFGSTRGIPKASSRDIPVILAQGGMGATTVASSLVAADLAGIPFFASAGIGGVHRGAERSMDISADLIQFTRSRVAVVCAGAKSILDLGLTLEYLETQCVPIISYQSDDFPAFYCRSSGFHSPHRLDDATVIARSIDMHWKLGNQSSVLITHPIHEEDAIGTDEVESIIREAAVQAEHEGIRGPGATPYLMRAVAKATEGKTVKANMSVLISTAALAGKLACAHIDYLRQQNQA", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to PsuG, PsuG that shares evolutionary origin and functional similarity; 2. The protein should be classified within Indigdn_synthA-like, Indigdn_synthA-like sharing conserved structural features. The designed protein sequence is ", "reference": "MSKTDFSHDLLRFSDEVKEALHSGKPVVALESTVIAHGLPYPENVATARKIEAAVRAEGAIPATIGIENGRFLIGMSDADLERFGSTRGIPKASSRDIPVILAQGGMGATTVASSLVAADLAGIPFFASAGIGGVHRGAERSMDISADLIQFTRSRVAVVCAGAKSILDLGLTLEYLETQCVPIISYQSDDFPAFYCRSSGFHSPHRLDDATVIARSIDMHWKLGNQSSVLITHPIHEEDAIGTDEVESIIREAAVQAEHEGIRGPGATPYLMRAVAKATEGKTVKANMSVLISTAALAGKLACAHIDYLRQQNQA" }, { "InterPro": [ { "InterPro-ID": "IPR001031", "InterPro-Name": "Thioesterase", "InterPro-Type": "DOMAIN", "Beg": 1230, "End": 1346 }, { "InterPro-ID": "IPR009081", "InterPro-Name": "PP-bd_ACP", "InterPro-Type": "DOMAIN", "Beg": 1145, "End": 1208 }, { "InterPro-ID": "IPR009081", "InterPro-Name": "PP-bd_ACP", "InterPro-Type": "DOMAIN", "Beg": 1137, "End": 1212 }, { "InterPro-ID": "IPR036736", "InterPro-Name": "ACP-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1133, "End": 1214 }, { "InterPro-ID": "IPR029058", "InterPro-Name": "AB_hydrolase_fold", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1211, "End": 1477 }, { "InterPro-ID": "IPR000873", "InterPro-Name": "AMP-dep_synth/lig_dom", "InterPro-Type": "DOMAIN", "Beg": 229, "End": 585 }, { "InterPro-ID": "IPR045851", "InterPro-Name": "AMP-bd_C_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1061, "End": 1132 }, { "InterPro-ID": "IPR045851", "InterPro-Name": "AMP-bd_C_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 630, "End": 724 }, { "InterPro-ID": "IPR029058", "InterPro-Name": "AB_hydrolase_fold", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1218, "End": 1481 }, { "InterPro-ID": "IPR010071", "InterPro-Name": "AA_adenyl_dom", "InterPro-Type": "DOMAIN", "Beg": 249, "End": 661 }, { "InterPro-ID": "IPR000415", "InterPro-Name": "Nitroreductase-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 745, "End": 930 }, { "InterPro-ID": "IPR020806", "InterPro-Name": "PKS_PP-bd", "InterPro-Type": "DOMAIN", "Beg": 1144, "End": 1212 }, { "InterPro-ID": "IPR036736", "InterPro-Name": "ACP-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1136, "End": 1208 }, { "InterPro-ID": "IPR020845", "InterPro-Name": "AMP-binding_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 376, "End": 387 } ], "response#1": "MDNISNHAFNYPVLVLNKGLLPEHDDIALARYLFSALALAVSRITQNEEMIVGFHLHPQEITRWKDDECIRQYILPLNIRFNSATPIAGFIREIMTWMTPDAIHQKNAMGASVLTLGPQHALHDIFDLEISWQPPVESEPVQALTCHVASREDALVLTLRFNPARFSATQMQKLPEVWRQITASAAKNGAETLRDIGLIDDAERQRVLHAFNQTEQAWDGETTVAARLKNRAQRHPEQTAVVFRDETLSYRQLYQQAGALAHYLNALETERERCVGLFVEPSLTLMTGVWGILLSGNAYLPLSPEYPEDRLAYMLENSQTRIIVTQPHLRERLLALAPPGIQVVTSDDVDAFMRQHAHSLPDAPQNDIAPHHLAYVIYTSGSTGKPKGVMIEHHSVLNQMNWLAQTVGLNQETVILQKTPMSFDAAQWEILSPACGCRVVMGEPGVYRNPEQLVDMLAEYRVTTLQCVPTLLQALLDTERLTHCPALRQIFSGGEALQKHLAQACLETLPDCELINLYGPTECTINNSAFRVDPVSVRQGPDTLSIGAPVANTRYYILDNCLTPVAVGQIGELYIGGDGVARGYLNRDDLTAERFIVDPFAPAGSGRRLYQTGDIASWNPDGTVQYAGRADNQVKLRGYRVELDEIRSAIETHEWVKAAAVIVRNDPFTGYQNLISFIELNAREAALMDQGNHGSHHQSKADKAQVMLQLANKGCREFPAASQPYTLDLPGKQPDEKQRLTAFSRKTYRFYDGGAVSREDILSLLHEPLLTAISRQPDALTLDELGHWLRYLGQFTSAERLLPKYTYASPGALYATQVFLELNGVAGLTAGHYYYQPVHHQLVRVSEQAAVTPGSLRLHFVGKKSAIEPIYKNNIREVLQMEMGHIIGMLDIILPDYGLGVALCDAAALDPTPLAIDLDDDYLGACDVLSGPRLPTDDDLDIYVQTAGANIADLPVGTYRYVRGDLQHIADDVIDKKHVIAINQAVYERSSFGISVASRTEGWAGYVHVGRKLQRLQMNPLNIGLMSSGYSSETGNDLPAARRFWQILGHRTGPYYFFIGGRISDEQKYSEGMREDAVHMKGPAEMIRDDLAAFMPDYMMPNKVLILDEMPLTANGKIDMKALANINVELKHKTIVAPRNPLEHQVMAIWQAKLKREEMSVDDNFFESGGNSLIAVSLINELNATLNASLPLQVLFQAPTVEKLAAWLSRARREPVSRLVQLQPKGRQAPIYCWPGLGGYCMNLRLLARQLGAERPFFGIQAHGINPDETPYATIGEMAARDIELIRQHQPHGPYTLWGYSFGARVAFETAWQLELAGEVVENLYLLAPGSPKLRDERVAAMNRKADFDNPGYLTILFSVFIGSITDPELERCLETVRDEESFVAFITGLNPALDDGLVRRITRIVAQTFEFTYTFSELQQRQLNAPVTIIKAQGDDYSFIENHGGFSAQPPTVLELMADHYSMLKAPGIDELTSVIQYQQSPPSLVG", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Thioesterase, PP-bd_ACP, PP-bd_ACP, AMP-dep_synth/lig_dom, AA_adenyl_dom, PKS_PP-bd that are essential for its biological function; 2. The protein should be classified within ACP-like_sf, AB_hydrolase_fold, AMP-bd_C_sf, AMP-bd_C_sf, AB_hydrolase_fold, Nitroreductase-like, ACP-like_sf sharing conserved structural features; 3. The protein should contain AMP-binding_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MDNISNHAFNYPVLVLNKGLLPEHDDIALARYLFSALALAVSRITQNEEMIVGFHLHPQEITRWKDDECIRQYILPLNIRFNSATPIAGFIREIMTWMTPDAIHQKNAMGASVLTLGPQHALHDIFDLEISWQPPVESEPVQALTCHVASREDALVLTLRFNPARFSATQMQKLPEVWRQITASAAKNGAETLRDIGLIDDAERQRVLHAFNQTEQAWDGETTVAARLKNRAQRHPEQTAVVFRDETLSYRQLYQQAGALAHYLNALETERERCVGLFVEPSLTLMTGVWGILLSGNAYLPLSPEYPEDRLAYMLENSQTRIIVTQPHLRERLLALAPPGIQVVTSDDVDAFMRQHAHSLPDAPQNDIAPHHLAYVIYTSGSTGKPKGVMIEHHSVLNQMNWLAQTVGLNQETVILQKTPMSFDAAQWEILSPACGCRVVMGEPGVYRNPEQLVDMLAEYRVTTLQCVPTLLQALLDTERLTHCPALRQIFSGGEALQKHLAQACLETLPDCELINLYGPTECTINNSAFRVDPVSVRQGPDTLSIGAPVANTRYYILDNCLTPVAVGQIGELYIGGDGVARGYLNRDDLTAERFIVDPFAPAGSGRRLYQTGDIASWNPDGTVQYAGRADNQVKLRGYRVELDEIRSAIETHEWVKAAAVIVRNDPFTGYQNLISFIELNAREAALMDQGNHGSHHQSKADKAQVMLQLANKGCREFPAASQPYTLDLPGKQPDEKQRLTAFSRKTYRFYDGGAVSREDILSLLHEPLLTAISRQPDALTLDELGHWLRYLGQFTSAERLLPKYTYASPGALYATQVFLELNGVAGLTAGHYYYQPVHHQLVRVSEQAAVTPGSLRLHFVGKKSAIEPIYKNNIREVLQMEMGHIIGMLDIILPDYGLGVALCDAAALDPTPLAIDLDDDYLGACDVLSGPRLPTDDDLDIYVQTAGANIADLPVGTYRYVRGDLQHIADDVIDKKHVIAINQAVYERSSFGISVASRTEGWAGYVHVGRKLQRLQMNPLNIGLMSSGYSSETGNDLPAARRFWQILGHRTGPYYFFIGGRISDEQKYSEGMREDAVHMKGPAEMIRDDLAAFMPDYMMPNKVLILDEMPLTANGKIDMKALANINVELKHKTIVAPRNPLEHQVMAIWQAKLKREEMSVDDNFFESGGNSLIAVSLINELNATLNASLPLQVLFQAPTVEKLAAWLSRARREPVSRLVQLQPKGRQAPIYCWPGLGGYCMNLRLLARQLGAERPFFGIQAHGINPDETPYATIGEMAARDIELIRQHQPHGPYTLWGYSFGARVAFETAWQLELAGEVVENLYLLAPGSPKLRDERVAAMNRKADFDNPGYLTILFSVFIGSITDPELERCLETVRDEESFVAFITGLNPALDDGLVRRITRIVAQTFEFTYTFSELQQRQLNAPVTIIKAQGDDYSFIENHGGFSAQPPTVLELMADHYSMLKAPGIDELTSVIQYQQSPPSLVG" }, { "InterPro": [ { "InterPro-ID": "IPR043130", "InterPro-Name": "CDP-OH_PTrfase_TM_dom", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 23, "End": 211 }, { "InterPro-ID": "IPR004570", "InterPro-Name": "Phosphatidylglycerol_P_synth", "InterPro-Type": "FAMILY", "Beg": 24, "End": 215 }, { "InterPro-ID": "IPR048254", "InterPro-Name": "CDP_ALCOHOL_P_TRANSF_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 76, "End": 98 }, { "InterPro-ID": "IPR050324", "InterPro-Name": "CDP-alcohol_PTase-I", "InterPro-Type": "FAMILY", "Beg": 22, "End": 202 }, { "InterPro-ID": "IPR000462", "InterPro-Name": "CDP-OH_P_trans", "InterPro-Type": "FAMILY", "Beg": 27, "End": 182 } ], "response#1": "MSIIGSFPPGGPRVEVQETRVQTDRVLTIPNILSMARLAGVPLFLWLILRPEFGGPQSDGWALLVLALSGVSDYLDGKLARRWNQISSLGRLLDPAADRLYILSTLVGLTWREILPLWLTLVLLAREAMLLVMVGILRRHGYPPPQVNFLGKAATFNLMYAFPLLLLSDGSGWIASLAAVFGWAFAGWGTTLYWWAGVLYVVQVRRLVRADVAAD", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Phosphatidylglycerol_P_synth, CDP-alcohol_PTase-I, CDP-OH_P_trans that shares evolutionary origin and functional similarity; 2. The protein should be classified within CDP-OH_PTrfase_TM_dom sharing conserved structural features; 3. The protein should contain CDP_ALCOHOL_P_TRANSF_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MSIIGSFPPGGPRVEVQETRVQTDRVLTIPNILSMARLAGVPLFLWLILRPEFGGPQSDGWALLVLALSGVSDYLDGKLARRWNQISSLGRLLDPAADRLYILSTLVGLTWREILPLWLTLVLLAREAMLLVMVGILRRHGYPPPQVNFLGKAATFNLMYAFPLLLLSDGSGWIASLAAVFGWAFAGWGTTLYWWAGVLYVVQVRRLVRADVAAD" }, { "InterPro": [ { "InterPro-ID": "IPR029063", "InterPro-Name": "SAM-dependent_MTases_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 32, "End": 211 }, { "InterPro-ID": "IPR016584", "InterPro-Name": "MeTrfase_VrtF", "InterPro-Type": "FAMILY", "Beg": 8, "End": 230 }, { "InterPro-ID": "IPR013217", "InterPro-Name": "Methyltransf_12", "InterPro-Type": "DOMAIN", "Beg": 65, "End": 163 }, { "InterPro-ID": "IPR029063", "InterPro-Name": "SAM-dependent_MTases_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 61, "End": 207 } ], "response#1": "MTTTSASTTDHLIDQQVIDGQAGYTKSFLNIYDLAVFKGTAPLAWHCSPAVSRQMYDTCLGANHVEIGVGTGYLLDNATFPVADPKITLVDLNPNSLAHTAQRLNRYDVTTVRANVLEPLPLEERAYDSVGMSYLLHCVPGSIKEKGIALKHAAAVVRPGGVVFGATVLSSGVPVSARGRWTMNYLNKRGDFHNQEDNYDDLRDQLAQYFPRFQLTSRGCVGIWRAWTTD", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Methyltransf_12 that are essential for its biological function; 2. The protein should belong to MeTrfase_VrtF that shares evolutionary origin and functional similarity; 3. The protein should be classified within SAM-dependent_MTases_sf, SAM-dependent_MTases_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MTTTSASTTDHLIDQQVIDGQAGYTKSFLNIYDLAVFKGTAPLAWHCSPAVSRQMYDTCLGANHVEIGVGTGYLLDNATFPVADPKITLVDLNPNSLAHTAQRLNRYDVTTVRANVLEPLPLEERAYDSVGMSYLLHCVPGSIKEKGIALKHAAAVVRPGGVVFGATVLSSGVPVSARGRWTMNYLNKRGDFHNQEDNYDDLRDQLAQYFPRFQLTSRGCVGIWRAWTTD" }, { "InterPro": [ { "InterPro-ID": "IPR002259", "InterPro-Name": "Eqnu_transpt", "InterPro-Type": "FAMILY", "Beg": 149, "End": 171 }, { "InterPro-ID": "IPR002259", "InterPro-Name": "Eqnu_transpt", "InterPro-Type": "FAMILY", "Beg": 468, "End": 492 }, { "InterPro-ID": "IPR002259", "InterPro-Name": "Eqnu_transpt", "InterPro-Type": "FAMILY", "Beg": 177, "End": 197 }, { "InterPro-ID": "IPR036259", "InterPro-Name": "MFS_trans_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 327, "End": 490 }, { "InterPro-ID": "IPR002259", "InterPro-Name": "Eqnu_transpt", "InterPro-Type": "FAMILY", "Beg": 25, "End": 492 }, { "InterPro-ID": "IPR002259", "InterPro-Name": "Eqnu_transpt", "InterPro-Type": "FAMILY", "Beg": 150, "End": 489 }, { "InterPro-ID": "IPR034764", "InterPro-Name": "ENT1/ENT2", "InterPro-Type": "FAMILY", "Beg": 33, "End": 495 } ], "response#1": "MSLKGGTAAPAPMAPPRKWYDMTSAEFYVYVVAFMCGISIMMPINAVFSAPSYMLEYYLYATKDPFLVPKMTNFWTNVMTYYNLISMVTSLVVEPLTLLKSFRKIPMLVRLLGGLSVLIIEIIVLMVVPARGTTEAGAVATMCIAGFIGGLGTSIFESTVYGMFGAFPPSFTSIMMGGVGISGVLTSLIQIIVKAALPDTYEGVKKQSYIYYSLDVGIQAATFIALIMMRFNSFAQLHFGDLGGVKSKVDAGSLAGAGENVREPGAEATELEQYTEPAIGQIQEKNAEAHKDDPLAERELSEEESGDSRAVEAAGEAPTSNEILRATSVFSVLRSVKWMFVACGFNFLITLFLFPGIATGMFPESKWFATVAVFIFNCCDVLGRFSSAFRITWPRRYNQRWIIVAASFARVIFVPLLLLHSYHYIPSEAYGYVMQVVFGLSSGYIASMALVLGPQSKGIDNDGKRFVAGTLMGISILVGGTIGTVLSIMTQTIRETY", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Eqnu_transpt, Eqnu_transpt, Eqnu_transpt, Eqnu_transpt, Eqnu_transpt, ENT1/ENT2 that shares evolutionary origin and functional similarity; 2. The protein should be classified within MFS_trans_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MSLKGGTAAPAPMAPPRKWYDMTSAEFYVYVVAFMCGISIMMPINAVFSAPSYMLEYYLYATKDPFLVPKMTNFWTNVMTYYNLISMVTSLVVEPLTLLKSFRKIPMLVRLLGGLSVLIIEIIVLMVVPARGTTEAGAVATMCIAGFIGGLGTSIFESTVYGMFGAFPPSFTSIMMGGVGISGVLTSLIQIIVKAALPDTYEGVKKQSYIYYSLDVGIQAATFIALIMMRFNSFAQLHFGDLGGVKSKVDAGSLAGAGENVREPGAEATELEQYTEPAIGQIQEKNAEAHKDDPLAERELSEEESGDSRAVEAAGEAPTSNEILRATSVFSVLRSVKWMFVACGFNFLITLFLFPGIATGMFPESKWFATVAVFIFNCCDVLGRFSSAFRITWPRRYNQRWIIVAASFARVIFVPLLLLHSYHYIPSEAYGYVMQVVFGLSSGYIASMALVLGPQSKGIDNDGKRFVAGTLMGISILVGGTIGTVLSIMTQTIRETY" }, { "InterPro": [ { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 41, "End": 357 }, { "InterPro-ID": "IPR032672", "InterPro-Name": "TmcA/NAT10/Kre33", "InterPro-Type": "FAMILY", "Beg": 555, "End": 740 }, { "InterPro-ID": "IPR000182", "InterPro-Name": "GNAT_dom", "InterPro-Type": "DOMAIN", "Beg": 442, "End": 556 }, { "InterPro-ID": "IPR007807", "InterPro-Name": "NAT10/TcmA_helicase", "InterPro-Type": "DOMAIN", "Beg": 236, "End": 409 }, { "InterPro-ID": "IPR016181", "InterPro-Name": "Acyl_CoA_acyltransferase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 465, "End": 583 }, { "InterPro-ID": "IPR013562", "InterPro-Name": "TmcA_N", "InterPro-Type": "DOMAIN", "Beg": 17, "End": 175 }, { "InterPro-ID": "IPR000182", "InterPro-Name": "GNAT_dom", "InterPro-Type": "DOMAIN", "Beg": 421, "End": 605 }, { "InterPro-ID": "IPR024914", "InterPro-Name": "tRNA_acetyltr_TmcA", "InterPro-Type": "FAMILY", "Beg": 26, "End": 742 }, { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 232, "End": 399 } ], "response#1": "MIPGSNPGGRIHNVIEMFENYFMDAVKGYYRHLAIIESQDPLEKINSLIDDYLKVNKKPRVIYGFHPWLDNSKDRMKELKKRFENFLDIDYSNSEKYLGQSADLVILDAMDDFRPNYIARFVDMTKGGGIAIIYSDNILEGKLYKKSLTRYGVVKDLFEARFIELAKRYRGIIFFQGNDRITFTPYSSNETHKPYKKIPKSPKVSMELHELCLSSDQNKVLEESLFIMNLGKRVLVITAARGRGKSASIGLFLSYLMSEGNFGSIIVTSPTYYSSQEIFKFIIRGLEALNVKYKVITSRDGKIMKISTRDSRVKWVSPDLAKNEEGDLIVIDEAAAMGIEFLDYIVRSWDKVILVTTIHGYEGSGKAFLKYVDKLKGKVLLKNIKMDYPIRYAKGDPIEKFLFDVFLLDAEPHEVEYNGKLKIVEVPQEELFRDDDLLKSVYGILVTAHYRNSPDDLMLLGDMAFQKVIVGYSSENPVAVCQVVYEGGLTDKQIWDISNGLKNEGHLIPHRLIKYMRALDFGKLKGWRIMRIAVSPENQGKGIGSRVIEEVIKMAKGVDWIGSSFVADYSVLRFWIKNGFLPVYLSSIKNEELNGYSVIVIKALSERTKEFVVKLSSLLKDKLLRTSHQVYYNLNPQLIVLLLRNTYSERIEGEVPDLYVDKIKAYTEGKVPYNVIAEAAHFLVTKHFLELKADLSIEAEASLVARVLQGKSWYHAGLMLGLSSREVEDNVKQSLGVLLETYT", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more GNAT_dom, NAT10/TcmA_helicase, TmcA_N, GNAT_dom that are essential for its biological function; 2. The protein should belong to TmcA/NAT10/Kre33, tRNA_acetyltr_TmcA that shares evolutionary origin and functional similarity; 3. The protein should be classified within P-loop_NTPase, Acyl_CoA_acyltransferase, P-loop_NTPase sharing conserved structural features. The designed protein sequence is ", "reference": "MIPGSNPGGRIHNVIEMFENYFMDAVKGYYRHLAIIESQDPLEKINSLIDDYLKVNKKPRVIYGFHPWLDNSKDRMKELKKRFENFLDIDYSNSEKYLGQSADLVILDAMDDFRPNYIARFVDMTKGGGIAIIYSDNILEGKLYKKSLTRYGVVKDLFEARFIELAKRYRGIIFFQGNDRITFTPYSSNETHKPYKKIPKSPKVSMELHELCLSSDQNKVLEESLFIMNLGKRVLVITAARGRGKSASIGLFLSYLMSEGNFGSIIVTSPTYYSSQEIFKFIIRGLEALNVKYKVITSRDGKIMKISTRDSRVKWVSPDLAKNEEGDLIVIDEAAAMGIEFLDYIVRSWDKVILVTTIHGYEGSGKAFLKYVDKLKGKVLLKNIKMDYPIRYAKGDPIEKFLFDVFLLDAEPHEVEYNGKLKIVEVPQEELFRDDDLLKSVYGILVTAHYRNSPDDLMLLGDMAFQKVIVGYSSENPVAVCQVVYEGGLTDKQIWDISNGLKNEGHLIPHRLIKYMRALDFGKLKGWRIMRIAVSPENQGKGIGSRVIEEVIKMAKGVDWIGSSFVADYSVLRFWIKNGFLPVYLSSIKNEELNGYSVIVIKALSERTKEFVVKLSSLLKDKLLRTSHQVYYNLNPQLIVLLLRNTYSERIEGEVPDLYVDKIKAYTEGKVPYNVIAEAAHFLVTKHFLELKADLSIEAEASLVARVLQGKSWYHAGLMLGLSSREVEDNVKQSLGVLLETYT" }, { "InterPro": [ { "InterPro-ID": "IPR036259", "InterPro-Name": "MFS_trans_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 55, "End": 248 }, { "InterPro-ID": "IPR039309", "InterPro-Name": "BT1", "InterPro-Type": "FAMILY", "Beg": 58, "End": 465 }, { "InterPro-ID": "IPR036259", "InterPro-Name": "MFS_trans_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 261, "End": 466 }, { "InterPro-ID": "IPR039309", "InterPro-Name": "BT1", "InterPro-Type": "FAMILY", "Beg": 64, "End": 466 }, { "InterPro-ID": "IPR036259", "InterPro-Name": "MFS_trans_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 56, "End": 459 } ], "response#1": "MEDDDFSIKDKKENYETCSTETISSYISINEKCQLIEKDINDDNHENPYMIFNKISSSLIAMLQGVEVLCNLSIIYLLKDNYHLHPASLSIVMCFIKIPWSIKLVWAVISDNYPIFGYRRKYYLLLGSFLCILSLICLGLITHNNLFITILLLFIYFFGSSLCNVIGEAQVVESNRNCSINSSARNVSLFFAFRKLSFAIMSYLSGYLLLLISKKHIFLIGSFLPICVFTSGFFIIEKRNYTKSSIKDQIKCIYSIIKLSYLKNFIIFIFIMMSTPSCGNTLFFYITNELKFSPNLLGKMAMFQSLASFISIISYMLFFTKIDIRKLLLYSTIIITPFCLLPLVVIKKVNYFLFIPNTLFFITDTVLIEFIAEFQTMPILVLCSRLIPEGFESTIYSLLLSSNNFASIISSFLSSLLTYSLNITSTNFTNLPYMIIICCLTNIIPIFFLYILPNHSQKKNLQHSNSHTQKYYSYPSTDYISSQKSDSSEITKFSADMQIDDITLE", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to BT1, BT1 that shares evolutionary origin and functional similarity; 2. The protein should be classified within MFS_trans_sf, MFS_trans_sf, MFS_trans_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MEDDDFSIKDKKENYETCSTETISSYISINEKCQLIEKDINDDNHENPYMIFNKISSSLIAMLQGVEVLCNLSIIYLLKDNYHLHPASLSIVMCFIKIPWSIKLVWAVISDNYPIFGYRRKYYLLLGSFLCILSLICLGLITHNNLFITILLLFIYFFGSSLCNVIGEAQVVESNRNCSINSSARNVSLFFAFRKLSFAIMSYLSGYLLLLISKKHIFLIGSFLPICVFTSGFFIIEKRNYTKSSIKDQIKCIYSIIKLSYLKNFIIFIFIMMSTPSCGNTLFFYITNELKFSPNLLGKMAMFQSLASFISIISYMLFFTKIDIRKLLLYSTIIITPFCLLPLVVIKKVNYFLFIPNTLFFITDTVLIEFIAEFQTMPILVLCSRLIPEGFESTIYSLLLSSNNFASIISSFLSSLLTYSLNITSTNFTNLPYMIIICCLTNIIPIFFLYILPNHSQKKNLQHSNSHTQKYYSYPSTDYISSQKSDSSEITKFSADMQIDDITLE" }, { "InterPro": [ { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 225, "End": 398 }, { "InterPro-ID": "IPR016181", "InterPro-Name": "Acyl_CoA_acyltransferase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 511, "End": 591 }, { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 154, "End": 391 }, { "InterPro-ID": "IPR013562", "InterPro-Name": "TmcA_N", "InterPro-Type": "DOMAIN", "Beg": 9, "End": 169 }, { "InterPro-ID": "IPR024914", "InterPro-Name": "tRNA_acetyltr_TmcA", "InterPro-Type": "FAMILY", "Beg": 19, "End": 747 }, { "InterPro-ID": "IPR032672", "InterPro-Name": "TmcA/NAT10/Kre33", "InterPro-Type": "FAMILY", "Beg": 4, "End": 552 }, { "InterPro-ID": "IPR000182", "InterPro-Name": "GNAT_dom", "InterPro-Type": "DOMAIN", "Beg": 458, "End": 608 }, { "InterPro-ID": "IPR000182", "InterPro-Name": "GNAT_dom", "InterPro-Type": "DOMAIN", "Beg": 555, "End": 607 }, { "InterPro-ID": "IPR000182", "InterPro-Name": "GNAT_dom", "InterPro-Type": "DOMAIN", "Beg": 441, "End": 553 }, { "InterPro-ID": "IPR007807", "InterPro-Name": "NAT10/TcmA_helicase", "InterPro-Type": "DOMAIN", "Beg": 228, "End": 408 } ], "response#1": "MVNKEQFYDQIRKALEDGNTRYYRNLIYIERDDYFDHVKEIISLFLNFKSNPSVAYGFVPWASGSKERMRTIKEYFSKFDDIDYANAEYYLGNTYDLVILDTVDNFQPINIGRLVDLARGGGLIIIYTNNLIKDKTFRTSIMRNGLILDEYEKRFKRKLYEHEGIFIIDVNEYIPKPFSGNTMPKAEKKVPRNPLMPKEIHELSLSEDQNRVIESFTYLLSGGQRALVLTAARGRGKSAATGLSIAGLIEKLRERKEKSIRIIVTAPSIASASQVMSFAKLGLEALGEELSVKVSDTGHIKSLRGDYFKLEYVPPDAAIEDEGELLIIDEAAALGINYIDLALRAWKKVALVTTVHGYEGSNKAFLRYLRRLIESKRIRVKWVNMEQPLRYAKGDPIEKWLYDALLLDAEPSEPQYLNDTMIYEDVDKSELANDDNRLRAIYGIMVTAHYKNNPDDLMIMLDGIHHKIKAIRIGENSYIAACQIAEEGELSDNMVDIALKGGTFDGDLIPDRIIKHVRIKDFAKLRGWRIVRIAVAPELQDKGFGSELLKMIYEEARDKGVDWVGSSFMSDQKVLNFWIKNGFIPVHISPKKNEKLGDYPVVVIRPISDIATKIVKISAYMLKEKLLNTLHDVYFNMNPEVVRLMLTSTKIVSKTINVSPIILDKTISFLQGVSPYESSADGIHMLTLKYFWDGERDWSLTQDEELVLIAKVLQGKPWSYVSTVLSSNRTHIYELIYSAISKLMKKYYNLTADSKVGLTLKDVMNSQQYD", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more TmcA_N, GNAT_dom, GNAT_dom, GNAT_dom, NAT10/TcmA_helicase that are essential for its biological function; 2. The protein should belong to tRNA_acetyltr_TmcA, TmcA/NAT10/Kre33 that shares evolutionary origin and functional similarity; 3. The protein should be classified within P-loop_NTPase, Acyl_CoA_acyltransferase, P-loop_NTPase sharing conserved structural features. The designed protein sequence is ", "reference": "MVNKEQFYDQIRKALEDGNTRYYRNLIYIERDDYFDHVKEIISLFLNFKSNPSVAYGFVPWASGSKERMRTIKEYFSKFDDIDYANAEYYLGNTYDLVILDTVDNFQPINIGRLVDLARGGGLIIIYTNNLIKDKTFRTSIMRNGLILDEYEKRFKRKLYEHEGIFIIDVNEYIPKPFSGNTMPKAEKKVPRNPLMPKEIHELSLSEDQNRVIESFTYLLSGGQRALVLTAARGRGKSAATGLSIAGLIEKLRERKEKSIRIIVTAPSIASASQVMSFAKLGLEALGEELSVKVSDTGHIKSLRGDYFKLEYVPPDAAIEDEGELLIIDEAAALGINYIDLALRAWKKVALVTTVHGYEGSNKAFLRYLRRLIESKRIRVKWVNMEQPLRYAKGDPIEKWLYDALLLDAEPSEPQYLNDTMIYEDVDKSELANDDNRLRAIYGIMVTAHYKNNPDDLMIMLDGIHHKIKAIRIGENSYIAACQIAEEGELSDNMVDIALKGGTFDGDLIPDRIIKHVRIKDFAKLRGWRIVRIAVAPELQDKGFGSELLKMIYEEARDKGVDWVGSSFMSDQKVLNFWIKNGFIPVHISPKKNEKLGDYPVVVIRPISDIATKIVKISAYMLKEKLLNTLHDVYFNMNPEVVRLMLTSTKIVSKTINVSPIILDKTISFLQGVSPYESSADGIHMLTLKYFWDGERDWSLTQDEELVLIAKVLQGKPWSYVSTVLSSNRTHIYELIYSAISKLMKKYYNLTADSKVGLTLKDVMNSQQYD" }, { "InterPro": [ { "InterPro-ID": "IPR002871", "InterPro-Name": "NIF_FeS_clus_asmbl_NifU_N", "InterPro-Type": "DOMAIN", "Beg": 25, "End": 140 }, { "InterPro-ID": "IPR002871", "InterPro-Name": "NIF_FeS_clus_asmbl_NifU_N", "InterPro-Type": "DOMAIN", "Beg": 17, "End": 153 }, { "InterPro-ID": "IPR002871", "InterPro-Name": "NIF_FeS_clus_asmbl_NifU_N", "InterPro-Type": "DOMAIN", "Beg": 26, "End": 150 }, { "InterPro-ID": "IPR011339", "InterPro-Name": "ISCU", "InterPro-Type": "FAMILY", "Beg": 26, "End": 149 } ], "response#1": "MSLVRNSSRLLRSQLKRVQSVPVALYHENVVEHYENPRNVGSLDKKDVTVGTGLVGAPACGDVMKLQIKVDENGKIVDAKFKTFGCGSAIASSSLATEWVKGKSIDEAGKLKNTDIAKELRLPPVKLHCSMLAEDAIKAALADYKVKQQKKVAN", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more NIF_FeS_clus_asmbl_NifU_N, NIF_FeS_clus_asmbl_NifU_N, NIF_FeS_clus_asmbl_NifU_N that are essential for its biological function; 2. The protein should belong to ISCU that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MSLVRNSSRLLRSQLKRVQSVPVALYHENVVEHYENPRNVGSLDKKDVTVGTGLVGAPACGDVMKLQIKVDENGKIVDAKFKTFGCGSAIASSSLATEWVKGKSIDEAGKLKNTDIAKELRLPPVKLHCSMLAEDAIKAALADYKVKQQKKVAN" }, { "InterPro": [ { "InterPro-ID": "IPR018042", "InterPro-Name": "Aspartate_kinase_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 28, "End": 36 }, { "InterPro-ID": "IPR036393", "InterPro-Name": "AceGlu_kinase-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 26, "End": 428 }, { "InterPro-ID": "IPR041747", "InterPro-Name": "AK-Hom3", "InterPro-Type": "DOMAIN", "Beg": 25, "End": 427 }, { "InterPro-ID": "IPR001048", "InterPro-Name": "Asp/Glu/Uridylate_kinase", "InterPro-Type": "DOMAIN", "Beg": 210, "End": 413 }, { "InterPro-ID": "IPR001341", "InterPro-Name": "Asp_kinase", "InterPro-Type": "FAMILY", "Beg": 177, "End": 597 }, { "InterPro-ID": "IPR045865", "InterPro-Name": "ACT-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 526, "End": 599 }, { "InterPro-ID": "IPR054352", "InterPro-Name": "ACT_Aspartokinase", "InterPro-Type": "DOMAIN", "Beg": 538, "End": 596 }, { "InterPro-ID": "IPR045865", "InterPro-Name": "ACT-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 450, "End": 526 }, { "InterPro-ID": "IPR036393", "InterPro-Name": "AceGlu_kinase-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 26, "End": 82 }, { "InterPro-ID": "IPR036393", "InterPro-Name": "AceGlu_kinase-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 174, "End": 427 } ], "response#1": "MSSASTPTAPYLEDLVRNSLDQNLPWVVQKYGGTSVGKSLDNITKIVGSYIDNGSKVAIVCSARSTQTKSLGTTNLLLQASREALQPAMSSSGDGRSGSMSGTATPFYPKRVGSGFFGKDQSTSMTSSVSSLSQLESQLGRSGSPSPFQSSSSRSPPRSPATPSQDSSISQEPAFHATVDLIKKGHLEAARASLKGGPLRDELEEEIERDCESLRSFLYAAQIIDEISPRSQDSIVGTGERLACKIVAAALRDRGVDSELVVLDNIVDASMSAASEAVSVDAGDQGVAQLGQEFYDQLSFRLGERLRECGQRVPVVTGYFGPVPGSLLAQIGRGYTDLCAALCAVGLKASELQVWKEVDGIFTADPRKVPSARLVPIITPDEAAELTYYGSEVIHPFTMEQVIRARIPIRIKNVENPSGAGTVIYPDVGFPRGLDTEPPKAERIVEGVDERMPTAVTIKDEIIVLNIHSNRKTLSHGFLARIFGTLDRAGVVVDLISTSEVHVSMAMQDFLNRKRLERLVKDLEKIGEVTVSKDMAILSLVGRNMRNAIGSAGLMFASLARAMINIEMISQGASEINISCVIENKDAIKALNVIHESCLSYPRSPATEMAGLQLQ", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more AK-Hom3, Asp/Glu/Uridylate_kinase, ACT_Aspartokinase that are essential for its biological function; 2. The protein should belong to Asp_kinase that shares evolutionary origin and functional similarity; 3. The protein should be classified within AceGlu_kinase-like_sf, ACT-like_dom_sf, ACT-like_dom_sf, AceGlu_kinase-like_sf, AceGlu_kinase-like_sf sharing conserved structural features; 4. The protein should contain Aspartate_kinase_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MSSASTPTAPYLEDLVRNSLDQNLPWVVQKYGGTSVGKSLDNITKIVGSYIDNGSKVAIVCSARSTQTKSLGTTNLLLQASREALQPAMSSSGDGRSGSMSGTATPFYPKRVGSGFFGKDQSTSMTSSVSSLSQLESQLGRSGSPSPFQSSSSRSPPRSPATPSQDSSISQEPAFHATVDLIKKGHLEAARASLKGGPLRDELEEEIERDCESLRSFLYAAQIIDEISPRSQDSIVGTGERLACKIVAAALRDRGVDSELVVLDNIVDASMSAASEAVSVDAGDQGVAQLGQEFYDQLSFRLGERLRECGQRVPVVTGYFGPVPGSLLAQIGRGYTDLCAALCAVGLKASELQVWKEVDGIFTADPRKVPSARLVPIITPDEAAELTYYGSEVIHPFTMEQVIRARIPIRIKNVENPSGAGTVIYPDVGFPRGLDTEPPKAERIVEGVDERMPTAVTIKDEIIVLNIHSNRKTLSHGFLARIFGTLDRAGVVVDLISTSEVHVSMAMQDFLNRKRLERLVKDLEKIGEVTVSKDMAILSLVGRNMRNAIGSAGLMFASLARAMINIEMISQGASEINISCVIENKDAIKALNVIHESCLSYPRSPATEMAGLQLQ" }, { "InterPro": [ { "InterPro-ID": "IPR000073", "InterPro-Name": "AB_hydrolase_1", "InterPro-Type": "DOMAIN", "Beg": 60, "End": 245 }, { "InterPro-ID": "IPR008220", "InterPro-Name": "HAT_MetX-like", "InterPro-Type": "FAMILY", "Beg": 2, "End": 496 }, { "InterPro-ID": "IPR029058", "InterPro-Name": "AB_hydrolase_fold", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 20, "End": 486 }, { "InterPro-ID": "IPR008220", "InterPro-Name": "HAT_MetX-like", "InterPro-Type": "FAMILY", "Beg": 14, "End": 486 }, { "InterPro-ID": "IPR029058", "InterPro-Name": "AB_hydrolase_fold", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 17, "End": 489 }, { "InterPro-ID": "IPR008220", "InterPro-Name": "HAT_MetX-like", "InterPro-Type": "FAMILY", "Beg": 29, "End": 400 }, { "InterPro-ID": "IPR008220", "InterPro-Name": "HAT_MetX-like", "InterPro-Type": "FAMILY", "Beg": 12, "End": 488 } ], "response#1": "MSDNTPTPQKNPDTNPYASLISQQIAIIPSFTLESGVTLNNVPVAYKTWGKLNEKADNCLVICHALTGSADVEDWWGPLLGLNKAFDPTRFFIFCGNVIGSPYGTISSVTTNPETGKPFGPEMPGSSVKDDVRLHYIILKSLGVRSVAAVVGGSMGGMTVLEYPLNTPPGFVRAIIPLATSARHSAWCISWGEAQRQSIYSDPDYKDGYYYEIEEEGGKVDLARQPARGLAAARMAALLTYRSRDSFESRFGRRAGGGKSSVPKGGVRIMGGQETTDPSVPSESDLAAKSPSWRAWREHNDGHRSAGARPISRSGSEGPAHREGDAAQAEVVKTQDVKANGNKIGTGGEAPPKIFSAQSYLRYQGDKFTGRFDANCYIHITRKLDTHDLSAPSRDTSLSSLSSGLPSSPDATEEELNARLIHALSLEPPALVIGIESDGLFTTSEQRELAAGIPDAELVVIPSPDGHDGFLLEFEAINGWVEGWLKRKMPEFYERRVINPEEYVQGEEGFGIKKESVFGEAEADVTRW", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more AB_hydrolase_1 that are essential for its biological function; 2. The protein should belong to HAT_MetX-like, HAT_MetX-like, HAT_MetX-like, HAT_MetX-like that shares evolutionary origin and functional similarity; 3. The protein should be classified within AB_hydrolase_fold, AB_hydrolase_fold sharing conserved structural features. The designed protein sequence is ", "reference": "MSDNTPTPQKNPDTNPYASLISQQIAIIPSFTLESGVTLNNVPVAYKTWGKLNEKADNCLVICHALTGSADVEDWWGPLLGLNKAFDPTRFFIFCGNVIGSPYGTISSVTTNPETGKPFGPEMPGSSVKDDVRLHYIILKSLGVRSVAAVVGGSMGGMTVLEYPLNTPPGFVRAIIPLATSARHSAWCISWGEAQRQSIYSDPDYKDGYYYEIEEEGGKVDLARQPARGLAAARMAALLTYRSRDSFESRFGRRAGGGKSSVPKGGVRIMGGQETTDPSVPSESDLAAKSPSWRAWREHNDGHRSAGARPISRSGSEGPAHREGDAAQAEVVKTQDVKANGNKIGTGGEAPPKIFSAQSYLRYQGDKFTGRFDANCYIHITRKLDTHDLSAPSRDTSLSSLSSGLPSSPDATEEELNARLIHALSLEPPALVIGIESDGLFTTSEQRELAAGIPDAELVVIPSPDGHDGFLLEFEAINGWVEGWLKRKMPEFYERRVINPEEYVQGEEGFGIKKESVFGEAEADVTRW" }, { "InterPro": [ { "InterPro-ID": "IPR016181", "InterPro-Name": "Acyl_CoA_acyltransferase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 489, "End": 643 }, { "InterPro-ID": "IPR024914", "InterPro-Name": "tRNA_acetyltr_TmcA", "InterPro-Type": "FAMILY", "Beg": 36, "End": 805 }, { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 259, "End": 396 }, { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 280, "End": 447 }, { "InterPro-ID": "IPR032672", "InterPro-Name": "TmcA/NAT10/Kre33", "InterPro-Type": "FAMILY", "Beg": 21, "End": 609 }, { "InterPro-ID": "IPR007807", "InterPro-Name": "NAT10/TcmA_helicase", "InterPro-Type": "DOMAIN", "Beg": 284, "End": 457 }, { "InterPro-ID": "IPR000182", "InterPro-Name": "GNAT_dom", "InterPro-Type": "DOMAIN", "Beg": 473, "End": 662 }, { "InterPro-ID": "IPR013562", "InterPro-Name": "TmcA_N", "InterPro-Type": "DOMAIN", "Beg": 28, "End": 221 }, { "InterPro-ID": "IPR000182", "InterPro-Name": "GNAT_dom", "InterPro-Type": "DOMAIN", "Beg": 497, "End": 610 }, { "InterPro-ID": "IPR000182", "InterPro-Name": "GNAT_dom", "InterPro-Type": "DOMAIN", "Beg": 611, "End": 663 } ], "response#1": "MTVKVRFDKEVRDYAKGEKVKDSILKLTETALAQALENFHRRMIVIEGDTLRKAELAGILAGASARVLSGILEELMKKRLRDESEDKIEVLYATDALGEETFGRKRYEAFRKHFDVLAGSNVEVKAVTFKHTRDILGRTYDLLILDMSYDYSPNDLGRIIETVRGGGLIFILAHPFEKWKNMWTGFHKSLVTPPYTIDDVKKRFNRRLIRKFTEHDGIYIITEGGKARKKPKRSKSQARIKARKGVPIPEETLFPKELYEMALTEGQVEVLKAFEELVEGGMLVLTADRGRGKSVSVGIGAIGLALALKKRTRIVVTAPELENVQALFRFAKRALERLGFKPYVVEERGLIKELYARKIGLRYYPPADGYKKSADLYILDEAAGIHVPILHKYLNKERVVYSSTIHGYEGAGRGFSVKFLKRAREKREFKELHMDEPIRYAENDPIERWLFDVLLLDAEPVELTEEDFELIEKKEVYLEEPDLDDWFENDREDLRNFVGIYILAHYRNRPSDVALLADAPHHEARVLRLKNGKIVTAIQIAKEGGIPKKVIEKMAKGYKPRGNIIPDMMVKHHYLKEFAKLKGYRIVRIATHPDAMDRGLGSKALELLEKEAREKGLDWIGSGFGASEELVRFWVRNGFAVVHLSPARNPVSGEFTAIVLKPISERAKKLIKKANDEFRIRLTEWLGDTHRELEPEIARWLFETPFGEAVDYPVHLTEIQKKRLDAFTGKVLTYDTVVDAVKPIVKLYFLDGWMKPYLDERQIRLLIYRVLQAHSWEETAKLIDRTETFTMIEVRDIIRGLWYYYKRLLKA", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more NAT10/TcmA_helicase, GNAT_dom, TmcA_N, GNAT_dom, GNAT_dom that are essential for its biological function; 2. The protein should belong to tRNA_acetyltr_TmcA, TmcA/NAT10/Kre33 that shares evolutionary origin and functional similarity; 3. The protein should be classified within Acyl_CoA_acyltransferase, P-loop_NTPase, P-loop_NTPase sharing conserved structural features. The designed protein sequence is ", "reference": "MTVKVRFDKEVRDYAKGEKVKDSILKLTETALAQALENFHRRMIVIEGDTLRKAELAGILAGASARVLSGILEELMKKRLRDESEDKIEVLYATDALGEETFGRKRYEAFRKHFDVLAGSNVEVKAVTFKHTRDILGRTYDLLILDMSYDYSPNDLGRIIETVRGGGLIFILAHPFEKWKNMWTGFHKSLVTPPYTIDDVKKRFNRRLIRKFTEHDGIYIITEGGKARKKPKRSKSQARIKARKGVPIPEETLFPKELYEMALTEGQVEVLKAFEELVEGGMLVLTADRGRGKSVSVGIGAIGLALALKKRTRIVVTAPELENVQALFRFAKRALERLGFKPYVVEERGLIKELYARKIGLRYYPPADGYKKSADLYILDEAAGIHVPILHKYLNKERVVYSSTIHGYEGAGRGFSVKFLKRAREKREFKELHMDEPIRYAENDPIERWLFDVLLLDAEPVELTEEDFELIEKKEVYLEEPDLDDWFENDREDLRNFVGIYILAHYRNRPSDVALLADAPHHEARVLRLKNGKIVTAIQIAKEGGIPKKVIEKMAKGYKPRGNIIPDMMVKHHYLKEFAKLKGYRIVRIATHPDAMDRGLGSKALELLEKEAREKGLDWIGSGFGASEELVRFWVRNGFAVVHLSPARNPVSGEFTAIVLKPISERAKKLIKKANDEFRIRLTEWLGDTHRELEPEIARWLFETPFGEAVDYPVHLTEIQKKRLDAFTGKVLTYDTVVDAVKPIVKLYFLDGWMKPYLDERQIRLLIYRVLQAHSWEETAKLIDRTETFTMIEVRDIIRGLWYYYKRLLKA" }, { "InterPro": [ { "InterPro-ID": "IPR052299", "InterPro-Name": "CEP76", "InterPro-Type": "FAMILY", "Beg": 58, "End": 1177 }, { "InterPro-ID": "IPR000008", "InterPro-Name": "C2_dom", "InterPro-Type": "DOMAIN", "Beg": 571, "End": 667 }, { "InterPro-ID": "IPR000008", "InterPro-Name": "C2_dom", "InterPro-Type": "DOMAIN", "Beg": 570, "End": 677 }, { "InterPro-ID": "IPR056288", "InterPro-Name": "CEP76_C", "InterPro-Type": "DOMAIN", "Beg": 1045, "End": 1180 }, { "InterPro-ID": "IPR035892", "InterPro-Name": "C2_domain_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 563, "End": 674 }, { "InterPro-ID": "IPR035892", "InterPro-Name": "C2_domain_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 569, "End": 694 }, { "InterPro-ID": "IPR000008", "InterPro-Name": "C2_dom", "InterPro-Type": "DOMAIN", "Beg": 557, "End": 678 }, { "InterPro-ID": "IPR056290", "InterPro-Name": "CEPT76/DRC7_peptidase-like_dom", "InterPro-Type": "DOMAIN", "Beg": 842, "End": 915 } ], "response#1": "MMKLKEMVEAAEAKVESKPPQAAEEKAPDQAAGGAEEDVAAAPAEGGEGAEPLDQAEIEKMLFDESLGAQEYTYEEFLDLIDQPPEERGEAEDERKHWSYPRRWKVVLWNLQIQNYMDDNFSAFMEFEFGGTREECKVHKGTSVLIYATGQDKNYLRTPVIPDVSNAGPVDMHFRKAFEYRGSYLDLEREKLKIKVWEYRNWTLNHLEAVYEEALLNLATGETHVERDLYKFIKGRRSRRCRISFHLYFQELYDFELSFVKWRLVQIMPCLTLQEKIANRGKNKGGYTREATIGFKRHQLADQAKYVFQQRQVKREMQKRDSQRELLPGASRPEMLGGFADKGSARLSHLGFESAMKLPNRGTRSPSGLESNRPEDGNRNMEEIFLQHQATILASDQLEELPASLRPPLSKRRKGEDKKDGNKADGPQVKMTISLMHASSMNKGLGLVSSERPADGIPRWDNLGEIYFRGTLRDLDSTYIQVVVEDTTAPKVMRQIGYGQIPLRGVVDYSCLSTELGTPMWLALQAKMEGWGHELKEWCFGFVEGTVMVAHLPRYRQLGEVSESDSDRVYLILRIKDVDQIVTPDNRPVVDSYVEVSFDGTSRRTRTVRNTLNPVWDDEVTIPLRLPAFRDITESDVTRKGKVWLDVWGTGPGYVDHLGGCSFSLYEIFFNEKHNKRNLTAMQRIDLEANTRQSYETRVFSTSRRLAFIHKADRPSTIQFEAWTCPDILEVSGIDKLPEPERITTTSNFPRALRNTYERLKRMYAEVIEKKGLVNPDTGVGPPRFFDVEFLDQRKETHYAPTMVTRIRPPFGVDSESSVFHYCRCVPFAVKRENLVFTPEFAVQIRSGNAMDHSILMTSLLLGLPAFAFVCVGTLWDKHMHAWVATFHYDDDRACGVVKFWETTTGLVYTLKHRFRDPYTLQRLSADPEFGILKMMNIQRRKRLSILGVSVDADTPDYISRSGEDLVQSEFPTGGAKLPYRSLDIMFNNRNVWLNIQDGNPAKVWFDIWDVEQWYQFSPGLHDVPPCFIVRGFGAKVAEWQFDRAAQEIQGKVLSDITAFRATRNLPTKWNRDDVLDAFLQMGLELLHQAATARDEDFQLARLKLEDWKKAFYSKVPCSYRVRGAPLHFNTYDSKTISDAIIANVDFVESRDRSAFFSLAVMLYNLPGELVSTYVYICVTQKVTERERRRILAQKEKQSREDAQRKARKQRRKAGHEGADNGAEDKQGAEGNEEEHGDAAAAAVAEESVSAEAVQGAEEPKKVVKKGAVPRVKKRSYEQVEGTEVAAIAIERDFFTEAEAPDFKNLMTDVEHAINTHLGLSPGRVRAFQARYAEKRIVFAVGPPMDDATEADAVSSVALMEKLRDILPSMAHEEGRFQEVTGGGATLQWDGPGTNILDRIAQEQATAGEGEQQTSEGIPTRDMQVDGTAVLEEAGEKSDKKKKKKEKKEKKEKKEKKEKKEKKEKKKKKGGETAAEPEEASAVLAPPPVPAPAAAIPSVLLPTDSEDGEKEKPKEKKKEKKEKKKKKDGETDAEPDEASAVLAPPPVPVPAAAIPSILLPADGEDGEEEKPKEKKTEKKKEKHTEKKHKKKSETLPESETTAVVTVTPGEEDETSPLVPVPSSIASSEAPEPPASTRVTPAPEPKAKPGLSMGAALLAVRARSRLQRKHLAQQLSSSSSSEVSASSASSLSPSSSSSSDFAETRAKADALRARLQAAQARLAAARETEVSSSETESSETSEASFLSSDGEWDALWQSQRAAAMERQQRLQKMVSGVKAAYRRLEEENTRLAATRRRDDKLQRQVEAERERAVELLKEATRRAKEEKDLIARQPPPARDWSDTVVLSTPQIFVNSQAACAPFADSGRDEGERDEWYEVSDACSRRAESSNESRTTAGAKLRQQQLDLAGRT", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more C2_dom, C2_dom, CEP76_C, C2_dom, CEPT76/DRC7_peptidase-like_dom that are essential for its biological function; 2. The protein should belong to CEP76 that shares evolutionary origin and functional similarity; 3. The protein should be classified within C2_domain_sf, C2_domain_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MMKLKEMVEAAEAKVESKPPQAAEEKAPDQAAGGAEEDVAAAPAEGGEGAEPLDQAEIEKMLFDESLGAQEYTYEEFLDLIDQPPEERGEAEDERKHWSYPRRWKVVLWNLQIQNYMDDNFSAFMEFEFGGTREECKVHKGTSVLIYATGQDKNYLRTPVIPDVSNAGPVDMHFRKAFEYRGSYLDLEREKLKIKVWEYRNWTLNHLEAVYEEALLNLATGETHVERDLYKFIKGRRSRRCRISFHLYFQELYDFELSFVKWRLVQIMPCLTLQEKIANRGKNKGGYTREATIGFKRHQLADQAKYVFQQRQVKREMQKRDSQRELLPGASRPEMLGGFADKGSARLSHLGFESAMKLPNRGTRSPSGLESNRPEDGNRNMEEIFLQHQATILASDQLEELPASLRPPLSKRRKGEDKKDGNKADGPQVKMTISLMHASSMNKGLGLVSSERPADGIPRWDNLGEIYFRGTLRDLDSTYIQVVVEDTTAPKVMRQIGYGQIPLRGVVDYSCLSTELGTPMWLALQAKMEGWGHELKEWCFGFVEGTVMVAHLPRYRQLGEVSESDSDRVYLILRIKDVDQIVTPDNRPVVDSYVEVSFDGTSRRTRTVRNTLNPVWDDEVTIPLRLPAFRDITESDVTRKGKVWLDVWGTGPGYVDHLGGCSFSLYEIFFNEKHNKRNLTAMQRIDLEANTRQSYETRVFSTSRRLAFIHKADRPSTIQFEAWTCPDILEVSGIDKLPEPERITTTSNFPRALRNTYERLKRMYAEVIEKKGLVNPDTGVGPPRFFDVEFLDQRKETHYAPTMVTRIRPPFGVDSESSVFHYCRCVPFAVKRENLVFTPEFAVQIRSGNAMDHSILMTSLLLGLPAFAFVCVGTLWDKHMHAWVATFHYDDDRACGVVKFWETTTGLVYTLKHRFRDPYTLQRLSADPEFGILKMMNIQRRKRLSILGVSVDADTPDYISRSGEDLVQSEFPTGGAKLPYRSLDIMFNNRNVWLNIQDGNPAKVWFDIWDVEQWYQFSPGLHDVPPCFIVRGFGAKVAEWQFDRAAQEIQGKVLSDITAFRATRNLPTKWNRDDVLDAFLQMGLELLHQAATARDEDFQLARLKLEDWKKAFYSKVPCSYRVRGAPLHFNTYDSKTISDAIIANVDFVESRDRSAFFSLAVMLYNLPGELVSTYVYICVTQKVTERERRRILAQKEKQSREDAQRKARKQRRKAGHEGADNGAEDKQGAEGNEEEHGDAAAAAVAEESVSAEAVQGAEEPKKVVKKGAVPRVKKRSYEQVEGTEVAAIAIERDFFTEAEAPDFKNLMTDVEHAINTHLGLSPGRVRAFQARYAEKRIVFAVGPPMDDATEADAVSSVALMEKLRDILPSMAHEEGRFQEVTGGGATLQWDGPGTNILDRIAQEQATAGEGEQQTSEGIPTRDMQVDGTAVLEEAGEKSDKKKKKKEKKEKKEKKEKKEKKEKKEKKKKKGGETAAEPEEASAVLAPPPVPAPAAAIPSVLLPTDSEDGEKEKPKEKKKEKKEKKKKKDGETDAEPDEASAVLAPPPVPVPAAAIPSILLPADGEDGEEEKPKEKKTEKKKEKHTEKKHKKKSETLPESETTAVVTVTPGEEDETSPLVPVPSSIASSEAPEPPASTRVTPAPEPKAKPGLSMGAALLAVRARSRLQRKHLAQQLSSSSSSEVSASSASSLSPSSSSSSDFAETRAKADALRARLQAAQARLAAARETEVSSSETESSETSEASFLSSDGEWDALWQSQRAAAMERQQRLQKMVSGVKAAYRRLEEENTRLAATRRRDDKLQRQVEAERERAVELLKEATRRAKEEKDLIARQPPPARDWSDTVVLSTPQIFVNSQAACAPFADSGRDEGERDEWYEVSDACSRRAESSNESRTTAGAKLRQQQLDLAGRT" }, { "InterPro": [ { "InterPro-ID": "IPR016039", "InterPro-Name": "Thiolase-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 298, "End": 336 }, { "InterPro-ID": "IPR001227", "InterPro-Name": "Ac_transferase_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1595, "End": 1710 }, { "InterPro-ID": "IPR009081", "InterPro-Name": "PP-bd_ACP", "InterPro-Type": "DOMAIN", "Beg": 1903, "End": 1968 }, { "InterPro-ID": "IPR009081", "InterPro-Name": "PP-bd_ACP", "InterPro-Type": "DOMAIN", "Beg": 975, "End": 1041 }, { "InterPro-ID": "IPR029058", "InterPro-Name": "AB_hydrolase_fold", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1930, "End": 2259 }, { "InterPro-ID": "IPR014043", "InterPro-Name": "Acyl_transferase_dom", "InterPro-Type": "DOMAIN", "Beg": 578, "End": 895 }, { "InterPro-ID": "IPR016035", "InterPro-Name": "Acyl_Trfase/lysoPLipase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 576, "End": 864 }, { "InterPro-ID": "IPR036299", "InterPro-Name": "Polyketide_synth_docking_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 11, "End": 43 }, { "InterPro-ID": "IPR016039", "InterPro-Name": "Thiolase-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 43, "End": 299 }, { "InterPro-ID": "IPR020841", "InterPro-Name": "PKS_Beta-ketoAc_synthase_dom", "InterPro-Type": "DOMAIN", "Beg": 42, "End": 334 }, { "InterPro-ID": "IPR020841", "InterPro-Name": "PKS_Beta-ketoAc_synthase_dom", "InterPro-Type": "DOMAIN", "Beg": 1063, "End": 1489 }, { "InterPro-ID": "IPR014030", "InterPro-Name": "Ketoacyl_synth_N", "InterPro-Type": "DOMAIN", "Beg": 1064, "End": 1314 }, { "InterPro-ID": "IPR014030", "InterPro-Name": "Ketoacyl_synth_N", "InterPro-Type": "DOMAIN", "Beg": 43, "End": 292 }, { "InterPro-ID": "IPR014031", "InterPro-Name": "Ketoacyl_synth_C", "InterPro-Type": "DOMAIN", "Beg": 300, "End": 336 }, { "InterPro-ID": "IPR014031", "InterPro-Name": "Ketoacyl_synth_C", "InterPro-Type": "DOMAIN", "Beg": 1322, "End": 1439 }, { "InterPro-ID": "IPR032821", "InterPro-Name": "PKS_assoc", "InterPro-Type": "DOMAIN", "Beg": 1442, "End": 1561 }, { "InterPro-ID": "IPR006162", "InterPro-Name": "Ppantetheine_attach_site", "InterPro-Type": "PTM", "Beg": 1927, "End": 1942 }, { "InterPro-ID": "IPR009081", "InterPro-Name": "PP-bd_ACP", "InterPro-Type": "DOMAIN", "Beg": 963, "End": 1045 }, { "InterPro-ID": "IPR001031", "InterPro-Name": "Thioesterase", "InterPro-Type": "DOMAIN", "Beg": 2045, "End": 2257 }, { "InterPro-ID": "IPR036736", "InterPro-Name": "ACP-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 967, "End": 1078 }, { "InterPro-ID": "IPR016039", "InterPro-Name": "Thiolase-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1061, "End": 1437 }, { "InterPro-ID": "IPR020802", "InterPro-Name": "PKS_thioesterase", "InterPro-Type": "DOMAIN", "Beg": 2046, "End": 2258 }, { "InterPro-ID": "IPR001227", "InterPro-Name": "Ac_transferase_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 577, "End": 880 }, { "InterPro-ID": "IPR001227", "InterPro-Name": "Ac_transferase_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1714, "End": 1814 }, { "InterPro-ID": "IPR020841", "InterPro-Name": "PKS_Beta-ketoAc_synthase_dom", "InterPro-Type": "DOMAIN", "Beg": 45, "End": 455 }, { "InterPro-ID": "IPR020841", "InterPro-Name": "PKS_Beta-ketoAc_synthase_dom", "InterPro-Type": "DOMAIN", "Beg": 1066, "End": 1492 }, { "InterPro-ID": "IPR036736", "InterPro-Name": "ACP-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 950, "End": 1049 }, { "InterPro-ID": "IPR036736", "InterPro-Name": "ACP-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1878, "End": 1976 }, { "InterPro-ID": "IPR009081", "InterPro-Name": "PP-bd_ACP", "InterPro-Type": "DOMAIN", "Beg": 1897, "End": 1972 }, { "InterPro-ID": "IPR018201", "InterPro-Name": "Ketoacyl_synth_AS", "InterPro-Type": "ACTIVE_SITE", "Beg": 1227, "End": 1243 }, { "InterPro-ID": "IPR020806", "InterPro-Name": "PKS_PP-bd", "InterPro-Type": "DOMAIN", "Beg": 1900, "End": 1972 }, { "InterPro-ID": "IPR020806", "InterPro-Name": "PKS_PP-bd", "InterPro-Type": "DOMAIN", "Beg": 973, "End": 1045 }, { "InterPro-ID": "IPR014043", "InterPro-Name": "Acyl_transferase_dom", "InterPro-Type": "DOMAIN", "Beg": 579, "End": 877 }, { "InterPro-ID": "IPR016036", "InterPro-Name": "Malonyl_transacylase_ACP-bd", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 703, "End": 768 }, { "InterPro-ID": "IPR016035", "InterPro-Name": "Acyl_Trfase/lysoPLipase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1600, "End": 1781 }, { "InterPro-ID": "IPR050091", "InterPro-Name": "PKS_NRPS_Biosynth_Enz", "InterPro-Type": "FAMILY", "Beg": 1065, "End": 1709 }, { "InterPro-ID": "IPR029058", "InterPro-Name": "AB_hydrolase_fold", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1989, "End": 2262 }, { "InterPro-ID": "IPR016039", "InterPro-Name": "Thiolase-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1066, "End": 1502 }, { "InterPro-ID": "IPR016039", "InterPro-Name": "Thiolase-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 45, "End": 336 }, { "InterPro-ID": "IPR015083", "InterPro-Name": "NorB/c/GfsB-D-like_docking", "InterPro-Type": "DOMAIN", "Beg": 12, "End": 39 } ], "response#1": "MTSGRGVSQMVTDDKLRYFLKKVTADLHETRGRLRELEEAAGEPIAVVAMGCRFPGGVRSPEDLWHLVASGRDAITPFPADRGWETAGLYDPDPDRPGKSCAREGGFLDDVASFDAGLFGVSPREALALDPQQRLLLEVTWETFERAGLTPAALRGTRTGVFVGTSSQEYAMLVHNARENFEGYSTGYLASVISGRLAYNFGLQGPAVTVDTACSSSLVALHQAAQALRAGDCTLALAGGVAVLATPSMFVEFSRQRGLAPDGRCKAFAAAADGTGWGEGVGLLLLERLSEARREGHPVLAVVRGSAVNQDGASNGLTAPNGPAQQRVIRRALAACRAVGGPGGRGGGPWHRDPAGRSHRGPGAAGHLRPRASRPTSFVARVVEVQYRPHPGRRRRRRCDQDGDGPAPRRTAAHPAYRRPHSTGGLVGGHRAAAHRGEGVAGDRPTPPGRRVLLRHQRHQRPCGAGTSRAGRLPRPRRTAGTAPGGDTAAALGALRPHRARPAGTGRPAARPYPRPPAPLPADTAHSLLVSRTLFGHRAVVLGDDRDELLTGLDALAGGGNAPGVLTGVAGEPRKPVLVFPGQGAQWEGMAAELYRESAVFRDRLRQCAEALAPHTGFSLVDVVCGAEGAAALDRVDVVQPALWAMLVSLAALWRSHGVEPGAVVGHSQGEIAAACVAGALSLEDGARIVALRSRLIAERLSGRGGMAFLGLPAGRAREWLAAWETRLGVAAVNGPSSVVVSGDAEALDGMLAAAEEEGVRAIRVAVDYASHSAQVATLEDELLAALPGITPRTAEIPFFSTVNGALIDTSALDPAYWYRNLRQTVRFESTVRRLLEAGHRGFVEVSPHPVLAVSVQEILDATATEGVVLASLRRGEGGLRRFLTSVGEAHVHGIPADFALPPGRLVDLPTLAFERRRYWLDAQPAAPAHQAEGSAGESAGESAGESAEESEAALFRQRLAGLPESERERAVLHTVCEQAAVVLNLTSAADLDTGKAFTDLGFVSMTAMELRNRLATATGIRLTPTAAFDHPTPEKLAAHLLSRLTGTAEPIAQPVAAPPAAGEPIAIVAMGCRYPGEVASPEELWELLAAGRDATSSFPANRGWNTDELYDPNPGRPGRTYVRRGGFLHDADQFDPQLFGISPREALAMDPQQRLLLEVAWEVLERARLSPASVRGSRTGVFMGISGQDYLPVLTASPDGGAGHLMTGTSTSVASGRIAYTFGLRGPAVTVDTACSSSLVALHLAIQALRQGDCSAALVGGATVLSTPGAFVEFSQQRALAPDGRCKAFAAGADGTGWGEGAGMLLVEPLSEARRQGHPVLALIRGSATNQDGASNGLSAPNGQAQQQVIRQALANSGLTTRDVDAVEAHGTGTALGDPIEAEALLATYGQDRPAQRPLWLGSLKSNIGHTAAAAGVGGVIKMVLALRRGVLPPTLHAADPTPHVDWSAGAVELLTEAREWPETGRPRRAGVSAFGISGTNAHVVLEQAPDPDPAPGSGLPHPAATLPAVPWPLSGRTAAALRAQAGRLHRFVLAHPGLAPADIGRSLAAGRAGLEHRAVVLGRDRDQLLAELATLAEGEGDDAGAAVRGTVRARSRMACLFTAGPGARSGPGRELYARMPVYAAAVDEAGAAFQALPARPLGETMALDEAPADPVLAQVLHFAEQVALFRLLDHWGTAPSHLLGHGPGEAAAAHCAGVLSLSDAAALLPALRATEDDIRRTVKELTFHPPRIPLVSGRTGRPLTPGELRSPEHWIALARETGTPAEGLRWLLADGVHHCLLPVPVDTAGIPGDLAEDGLLLLPDPSRDGTGATALLRALARLYVRGVAVGWDRMLADCGARLVELPTYAFQRGRYWPELAALPAAGPRPAGRADGQGGREFQERLAGASEEEREALLAALVRTHAAAALRLPDADAIDERTPLPELGFDSLTAVDLRNRLGADTGLRLAPSLVFQHPTVTALARHLLAAWTAAGGADRAAEDTTGAGTTLGPLLARAGELGRSEEFQELMHRMAAFRPAFDTPRAEHRIPPVRLSRGPAAPGLVCFPTFAGSSGPQQYARLAAAARGERDLWVLPAPGFSWDQPLPASVDALARLQADGVQECAEGQPVVLLGYSAGGWIAHATAAALEARGAGPSGVVLLDTYWPDSAMLPRLHARIDQDRKSGSSEAHWTEEIRDDAGLTAMAHYSRLFQTWRPAPITAPTLLVRAAEPAVAEPPRDWRPHWRLPHTAVDAPGTHFTLIREHGPAALGSVHHWLNGLQKKEH", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more PP-bd_ACP, PP-bd_ACP, Acyl_transferase_dom, PKS_Beta-ketoAc_synthase_dom, PKS_Beta-ketoAc_synthase_dom, Ketoacyl_synth_N, Ketoacyl_synth_N, Ketoacyl_synth_C, Ketoacyl_synth_C, PKS_assoc, PP-bd_ACP, Thioesterase, PKS_thioesterase, PKS_Beta-ketoAc_synthase_dom, PKS_Beta-ketoAc_synthase_dom, PP-bd_ACP, PKS_PP-bd, PKS_PP-bd, Acyl_transferase_dom, NorB/c/GfsB-D-like_docking that are essential for its biological function; 2. The protein should belong to PKS_NRPS_Biosynth_Enz that shares evolutionary origin and functional similarity; 3. The protein should be classified within Thiolase-like, Ac_transferase_dom_sf, AB_hydrolase_fold, Acyl_Trfase/lysoPLipase, Polyketide_synth_docking_sf, Thiolase-like, ACP-like_sf, Thiolase-like, Ac_transferase_dom_sf, Ac_transferase_dom_sf, ACP-like_sf, ACP-like_sf, Malonyl_transacylase_ACP-bd, Acyl_Trfase/lysoPLipase, AB_hydrolase_fold, Thiolase-like, Thiolase-like sharing conserved structural features; 4. The protein must have Ketoacyl_synth_AS that is conserved among related catalytic enzymes; 5. The protein should contain Ppantetheine_attach_site that allow regulation through chemical modifications. The designed protein sequence is ", "reference": "MTSGRGVSQMVTDDKLRYFLKKVTADLHETRGRLRELEEAAGEPIAVVAMGCRFPGGVRSPEDLWHLVASGRDAITPFPADRGWETAGLYDPDPDRPGKSCAREGGFLDDVASFDAGLFGVSPREALALDPQQRLLLEVTWETFERAGLTPAALRGTRTGVFVGTSSQEYAMLVHNARENFEGYSTGYLASVISGRLAYNFGLQGPAVTVDTACSSSLVALHQAAQALRAGDCTLALAGGVAVLATPSMFVEFSRQRGLAPDGRCKAFAAAADGTGWGEGVGLLLLERLSEARREGHPVLAVVRGSAVNQDGASNGLTAPNGPAQQRVIRRALAACRAVGGPGGRGGGPWHRDPAGRSHRGPGAAGHLRPRASRPTSFVARVVEVQYRPHPGRRRRRRCDQDGDGPAPRRTAAHPAYRRPHSTGGLVGGHRAAAHRGEGVAGDRPTPPGRRVLLRHQRHQRPCGAGTSRAGRLPRPRRTAGTAPGGDTAAALGALRPHRARPAGTGRPAARPYPRPPAPLPADTAHSLLVSRTLFGHRAVVLGDDRDELLTGLDALAGGGNAPGVLTGVAGEPRKPVLVFPGQGAQWEGMAAELYRESAVFRDRLRQCAEALAPHTGFSLVDVVCGAEGAAALDRVDVVQPALWAMLVSLAALWRSHGVEPGAVVGHSQGEIAAACVAGALSLEDGARIVALRSRLIAERLSGRGGMAFLGLPAGRAREWLAAWETRLGVAAVNGPSSVVVSGDAEALDGMLAAAEEEGVRAIRVAVDYASHSAQVATLEDELLAALPGITPRTAEIPFFSTVNGALIDTSALDPAYWYRNLRQTVRFESTVRRLLEAGHRGFVEVSPHPVLAVSVQEILDATATEGVVLASLRRGEGGLRRFLTSVGEAHVHGIPADFALPPGRLVDLPTLAFERRRYWLDAQPAAPAHQAEGSAGESAGESAGESAEESEAALFRQRLAGLPESERERAVLHTVCEQAAVVLNLTSAADLDTGKAFTDLGFVSMTAMELRNRLATATGIRLTPTAAFDHPTPEKLAAHLLSRLTGTAEPIAQPVAAPPAAGEPIAIVAMGCRYPGEVASPEELWELLAAGRDATSSFPANRGWNTDELYDPNPGRPGRTYVRRGGFLHDADQFDPQLFGISPREALAMDPQQRLLLEVAWEVLERARLSPASVRGSRTGVFMGISGQDYLPVLTASPDGGAGHLMTGTSTSVASGRIAYTFGLRGPAVTVDTACSSSLVALHLAIQALRQGDCSAALVGGATVLSTPGAFVEFSQQRALAPDGRCKAFAAGADGTGWGEGAGMLLVEPLSEARRQGHPVLALIRGSATNQDGASNGLSAPNGQAQQQVIRQALANSGLTTRDVDAVEAHGTGTALGDPIEAEALLATYGQDRPAQRPLWLGSLKSNIGHTAAAAGVGGVIKMVLALRRGVLPPTLHAADPTPHVDWSAGAVELLTEAREWPETGRPRRAGVSAFGISGTNAHVVLEQAPDPDPAPGSGLPHPAATLPAVPWPLSGRTAAALRAQAGRLHRFVLAHPGLAPADIGRSLAAGRAGLEHRAVVLGRDRDQLLAELATLAEGEGDDAGAAVRGTVRARSRMACLFTAGPGARSGPGRELYARMPVYAAAVDEAGAAFQALPARPLGETMALDEAPADPVLAQVLHFAEQVALFRLLDHWGTAPSHLLGHGPGEAAAAHCAGVLSLSDAAALLPALRATEDDIRRTVKELTFHPPRIPLVSGRTGRPLTPGELRSPEHWIALARETGTPAEGLRWLLADGVHHCLLPVPVDTAGIPGDLAEDGLLLLPDPSRDGTGATALLRALARLYVRGVAVGWDRMLADCGARLVELPTYAFQRGRYWPELAALPAAGPRPAGRADGQGGREFQERLAGASEEEREALLAALVRTHAAAALRLPDADAIDERTPLPELGFDSLTAVDLRNRLGADTGLRLAPSLVFQHPTVTALARHLLAAWTAAGGADRAAEDTTGAGTTLGPLLARAGELGRSEEFQELMHRMAAFRPAFDTPRAEHRIPPVRLSRGPAAPGLVCFPTFAGSSGPQQYARLAAAARGERDLWVLPAPGFSWDQPLPASVDALARLQADGVQECAEGQPVVLLGYSAGGWIAHATAAALEARGAGPSGVVLLDTYWPDSAMLPRLHARIDQDRKSGSSEAHWTEEIRDDAGLTAMAHYSRLFQTWRPAPITAPTLLVRAAEPAVAEPPRDWRPHWRLPHTAVDAPGTHFTLIREHGPAALGSVHHWLNGLQKKEH" }, { "InterPro": [ { "InterPro-ID": "IPR015083", "InterPro-Name": "NorB/c/GfsB-D-like_docking", "InterPro-Type": "DOMAIN", "Beg": 5, "End": 31 }, { "InterPro-ID": "IPR036291", "InterPro-Name": "NAD(P)-bd_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1523, "End": 1697 }, { "InterPro-ID": "IPR016039", "InterPro-Name": "Thiolase-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 31, "End": 407 }, { "InterPro-ID": "IPR011032", "InterPro-Name": "GroES-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1426, "End": 1560 }, { "InterPro-ID": "IPR055123", "InterPro-Name": "SpnB-like_Rossmann", "InterPro-Type": "DOMAIN", "Beg": 1238, "End": 1398 }, { "InterPro-ID": "IPR018201", "InterPro-Name": "Ketoacyl_synth_AS", "InterPro-Type": "ACTIVE_SITE", "Beg": 197, "End": 213 }, { "InterPro-ID": "IPR016035", "InterPro-Name": "Acyl_Trfase/lysoPLipase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 565, "End": 856 }, { "InterPro-ID": "IPR020843", "InterPro-Name": "PKS_ER", "InterPro-Type": "DOMAIN", "Beg": 1424, "End": 1726 }, { "InterPro-ID": "IPR002364", "InterPro-Name": "Quin_OxRdtase/zeta-crystal_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 1551, "End": 1572 }, { "InterPro-ID": "IPR001227", "InterPro-Name": "Ac_transferase_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 566, "End": 874 }, { "InterPro-ID": "IPR013154", "InterPro-Name": "ADH-like_N", "InterPro-Type": "DOMAIN", "Beg": 1443, "End": 1498 }, { "InterPro-ID": "IPR014031", "InterPro-Name": "Ketoacyl_synth_C", "InterPro-Type": "DOMAIN", "Beg": 292, "End": 409 }, { "InterPro-ID": "IPR049552", "InterPro-Name": "PKS_DH_N", "InterPro-Type": "DOMAIN", "Beg": 938, "End": 1038 }, { "InterPro-ID": "IPR036291", "InterPro-Name": "NAD(P)-bd_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1216, "End": 1400 }, { "InterPro-ID": "IPR042104", "InterPro-Name": "PKS_dehydratase_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 927, "End": 1215 }, { "InterPro-ID": "IPR009081", "InterPro-Name": "PP-bd_ACP", "InterPro-Type": "DOMAIN", "Beg": 2022, "End": 2088 }, { "InterPro-ID": "IPR016039", "InterPro-Name": "Thiolase-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 26, "End": 472 }, { "InterPro-ID": "IPR014043", "InterPro-Name": "Acyl_transferase_dom", "InterPro-Type": "DOMAIN", "Beg": 568, "End": 871 }, { "InterPro-ID": "IPR036736", "InterPro-Name": "ACP-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 2014, "End": 2100 }, { "InterPro-ID": "IPR020841", "InterPro-Name": "PKS_Beta-ketoAc_synthase_dom", "InterPro-Type": "DOMAIN", "Beg": 34, "End": 459 }, { "InterPro-ID": "IPR013968", "InterPro-Name": "PKS_KR", "InterPro-Type": "DOMAIN", "Beg": 1736, "End": 1915 }, { "InterPro-ID": "IPR016036", "InterPro-Name": "Malonyl_transacylase_ACP-bd", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 694, "End": 759 }, { "InterPro-ID": "IPR009081", "InterPro-Name": "PP-bd_ACP", "InterPro-Type": "DOMAIN", "Beg": 2017, "End": 2092 }, { "InterPro-ID": "IPR036291", "InterPro-Name": "NAD(P)-bd_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1730, "End": 1973 }, { "InterPro-ID": "IPR036736", "InterPro-Name": "ACP-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1997, "End": 2095 }, { "InterPro-ID": "IPR020807", "InterPro-Name": "PKS_DH", "InterPro-Type": "DOMAIN", "Beg": 938, "End": 1099 }, { "InterPro-ID": "IPR049551", "InterPro-Name": "PKS_DH_C", "InterPro-Type": "DOMAIN", "Beg": 1064, "End": 1211 }, { "InterPro-ID": "IPR032821", "InterPro-Name": "PKS_assoc", "InterPro-Type": "DOMAIN", "Beg": 412, "End": 522 }, { "InterPro-ID": "IPR049900", "InterPro-Name": "PKS_mFAS_DH", "InterPro-Type": "DOMAIN", "Beg": 938, "End": 1212 }, { "InterPro-ID": "IPR020806", "InterPro-Name": "PKS_PP-bd", "InterPro-Type": "DOMAIN", "Beg": 2020, "End": 2092 }, { "InterPro-ID": "IPR006162", "InterPro-Name": "Ppantetheine_attach_site", "InterPro-Type": "PTM", "Beg": 2047, "End": 2062 }, { "InterPro-ID": "IPR020841", "InterPro-Name": "PKS_Beta-ketoAc_synthase_dom", "InterPro-Type": "DOMAIN", "Beg": 37, "End": 462 }, { "InterPro-ID": "IPR050091", "InterPro-Name": "PKS_NRPS_Biosynth_Enz", "InterPro-Type": "FAMILY", "Beg": 23, "End": 2091 }, { "InterPro-ID": "IPR014043", "InterPro-Name": "Acyl_transferase_dom", "InterPro-Type": "DOMAIN", "Beg": 567, "End": 888 }, { "InterPro-ID": "IPR014030", "InterPro-Name": "Ketoacyl_synth_N", "InterPro-Type": "DOMAIN", "Beg": 35, "End": 284 } ], "response#1": "MPVGDDKLVEALRASLKETENLRARNRELRAAAREPVAVVAMGCRFPGGVKSPEDLWHLVAEGTDAISPFPADRGWDTDSLFDSDPGRPGHTYVLEGGFLDDAAEFDADLFGISPREAVAMDPQQRLLLETAWETFERAGINPASLRGRPVGTFVGSVLTTNGGGAEPAEGSEGHQLTGSAASVLSGRLAYTFGLEGPAVTVDTACSAALASVHLAVQALRQRECAMALAGGSAVLTTPGIFVEFSRQRGLAPDGRCKPFAAAADGTGWGEGVGLVLLERLSDARRRGHPVLAVIRGSAVNQDGASNGLTAPNGPSQQRVIRQALAAARLSADLVDAVEAHGTGTTLGDPIEAQALLATYGQDRPADRPLWLGSVKSNLGHTQGAAGIAGLIKMVLAMRHGVLPRTLHIDRPTPHVDWSSGAVRLLTENREWPPTGRPRRAAVSSFGISGTNAHVILEQAPAEGEMTDGPEGADIPAVGLPLVLSARGDRALRQQAERLAAHLRARSGLRPPDVGHSLVTSRATLDQRAVVWSGDRDGLLAGLDALAQDRPAPGLTRGTATEGALAFLFSGQGSQRPGMGRQLAGEFPVFAEALDEAAGHLDPRLDRPLREILHAEEGTPRAALLEQTAFTQAALFAYEMAMFRLLTHWGITPALLLGHSVGELAAAHAAGVFSLEDACTLVAARGRLMQRMPGTGAMVAIQATEAEVLPLVAARAGEISLAAVNGPCSVVVSGAEGAVLEVAGYWKERGRRTSRLRVSHAFHSPQMTGMLQEFGEVAGKLEFHPPRIPVVSNLTGEIATDEQLCSPEYWVRHAQAPVRFHTGMRALVAAGVRTFMEVGPSGTLTAMAQDCLAEQPAATGAVVIPVARSGRPETGTTLAAVSRAFVQGTPVDWTRFFPQTGNRRVELPTYPFQRRGYPWSRASATAQVTAAGLAGLRHPLLGACLELADGQGTVFSGRLSRRTESWLAHHKVLGTALVPGTAIVEMALRAGTEARCGRLVELTQEAPLTLPDQGAVHLQVRVGAPGENGHRSLGVYSRPEEAPDWVCHARGQLAPEAAAPPAAPGEDWPPPGAEPVPLEGFYERLAAEGLDYGPAFRGLSRAWRLGEAVFAELALDRTARAGAGAYGVHPALLDSALHLALLDGALAGRSRLRIPFAWQDVSCHGAGAPALRARLTPAGTDSVSLALWDEHGAPVASVGSLVTRPITAGQLRATRTQDTLFHLNWAAAEPVPGAAPGCVVLGDDDLAAAVAAPGLPGPEALLAALDSGESIPGLVLLPCRAPDADTPDADDPLAAARSLTGRVLEVIHHWLTDARLTDSRLAVITRGALSAADGEPVTDPAAAALWGLVRSAQSEHPGRFLLADLDGHPGSTAALPAALSGNEPQLALREGRLLVPRLARGVPEGSLMPPPGAAEWRVAPAGGGTVDDLVLAPCPEAAAPLAPGQVRVAVRAAGLNFRDVVMALGMVADQRALGGEIAGVVTEVGPDVPGLAPGDRVFGLAAGCLGPVAVADHRLIAPMPPDWSFPQAAAVPVTFLTAFHGLVDLAGLRAGEKVLIHAAAGGVGIAAVQLARHLGAEVFATASPAKWDAVRALGVDEGHLASSRTGEFEARFAGSGGVDVVLNSLTGELLDASLRLLRPGGRFVEMGKTDIRDAARIAGEHQGVRYRAFDLMDAGPGRIAEMLAEILALFERGRLRPVPVRTWDVRQAPAAFRFLAQARNVGKLVLTMPPAWDPSGTILVTGGYGALGTEVARHLVRTGRARHLLLAGRRGPEAEGMAELTEELRKLGALSVRAVACDMAERASVAELLASVPAEHPLTAVVHTAGVVDDGLLESMTPRRLDTVFRPKADGAWHLHELTRDRELAAFVLFSSAAGTLGAAGQANYAAANAFLDALAAHRRDAGLPATALAWGMWAGTGGMAAALDRAGLDRVSRSGIAGLSTEDGLALFDAALAADRAVWLPIRFHTPALRTAAGQGSLPPLLRGLAGTPADPAAPAGAANALRERLAALAPGERRPAVRELVRGQVAAVLGHPTAETVDPQRPFKELGFDSLTAVELRNRLGAMTGLTLPSTLVFDHPTPDALTDAIEARLPAGPGAPAESFLARLDDWAAGLAAAPLDQDERERVAARLRALALRWEEGTRPQDTGPAVAGELDLATDEEVIDFISNELGIS", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more NorB/c/GfsB-D-like_docking, SpnB-like_Rossmann, PKS_ER, ADH-like_N, Ketoacyl_synth_C, PKS_DH_N, PP-bd_ACP, Acyl_transferase_dom, PKS_Beta-ketoAc_synthase_dom, PKS_KR, PP-bd_ACP, PKS_DH, PKS_DH_C, PKS_assoc, PKS_mFAS_DH, PKS_PP-bd, PKS_Beta-ketoAc_synthase_dom, Acyl_transferase_dom, Ketoacyl_synth_N that are essential for its biological function; 2. The protein should belong to PKS_NRPS_Biosynth_Enz that shares evolutionary origin and functional similarity; 3. The protein should be classified within NAD(P)-bd_dom_sf, Thiolase-like, GroES-like_sf, Acyl_Trfase/lysoPLipase, Ac_transferase_dom_sf, NAD(P)-bd_dom_sf, PKS_dehydratase_sf, Thiolase-like, ACP-like_sf, Malonyl_transacylase_ACP-bd, NAD(P)-bd_dom_sf, ACP-like_sf sharing conserved structural features; 4. The protein should contain Quin_OxRdtase/zeta-crystal_CS that is preserved across related proteins; 5. The protein must have Ketoacyl_synth_AS that is conserved among related catalytic enzymes; 6. The protein should contain Ppantetheine_attach_site that allow regulation through chemical modifications. The designed protein sequence is ", "reference": "MPVGDDKLVEALRASLKETENLRARNRELRAAAREPVAVVAMGCRFPGGVKSPEDLWHLVAEGTDAISPFPADRGWDTDSLFDSDPGRPGHTYVLEGGFLDDAAEFDADLFGISPREAVAMDPQQRLLLETAWETFERAGINPASLRGRPVGTFVGSVLTTNGGGAEPAEGSEGHQLTGSAASVLSGRLAYTFGLEGPAVTVDTACSAALASVHLAVQALRQRECAMALAGGSAVLTTPGIFVEFSRQRGLAPDGRCKPFAAAADGTGWGEGVGLVLLERLSDARRRGHPVLAVIRGSAVNQDGASNGLTAPNGPSQQRVIRQALAAARLSADLVDAVEAHGTGTTLGDPIEAQALLATYGQDRPADRPLWLGSVKSNLGHTQGAAGIAGLIKMVLAMRHGVLPRTLHIDRPTPHVDWSSGAVRLLTENREWPPTGRPRRAAVSSFGISGTNAHVILEQAPAEGEMTDGPEGADIPAVGLPLVLSARGDRALRQQAERLAAHLRARSGLRPPDVGHSLVTSRATLDQRAVVWSGDRDGLLAGLDALAQDRPAPGLTRGTATEGALAFLFSGQGSQRPGMGRQLAGEFPVFAEALDEAAGHLDPRLDRPLREILHAEEGTPRAALLEQTAFTQAALFAYEMAMFRLLTHWGITPALLLGHSVGELAAAHAAGVFSLEDACTLVAARGRLMQRMPGTGAMVAIQATEAEVLPLVAARAGEISLAAVNGPCSVVVSGAEGAVLEVAGYWKERGRRTSRLRVSHAFHSPQMTGMLQEFGEVAGKLEFHPPRIPVVSNLTGEIATDEQLCSPEYWVRHAQAPVRFHTGMRALVAAGVRTFMEVGPSGTLTAMAQDCLAEQPAATGAVVIPVARSGRPETGTTLAAVSRAFVQGTPVDWTRFFPQTGNRRVELPTYPFQRRGYPWSRASATAQVTAAGLAGLRHPLLGACLELADGQGTVFSGRLSRRTESWLAHHKVLGTALVPGTAIVEMALRAGTEARCGRLVELTQEAPLTLPDQGAVHLQVRVGAPGENGHRSLGVYSRPEEAPDWVCHARGQLAPEAAAPPAAPGEDWPPPGAEPVPLEGFYERLAAEGLDYGPAFRGLSRAWRLGEAVFAELALDRTARAGAGAYGVHPALLDSALHLALLDGALAGRSRLRIPFAWQDVSCHGAGAPALRARLTPAGTDSVSLALWDEHGAPVASVGSLVTRPITAGQLRATRTQDTLFHLNWAAAEPVPGAAPGCVVLGDDDLAAAVAAPGLPGPEALLAALDSGESIPGLVLLPCRAPDADTPDADDPLAAARSLTGRVLEVIHHWLTDARLTDSRLAVITRGALSAADGEPVTDPAAAALWGLVRSAQSEHPGRFLLADLDGHPGSTAALPAALSGNEPQLALREGRLLVPRLARGVPEGSLMPPPGAAEWRVAPAGGGTVDDLVLAPCPEAAAPLAPGQVRVAVRAAGLNFRDVVMALGMVADQRALGGEIAGVVTEVGPDVPGLAPGDRVFGLAAGCLGPVAVADHRLIAPMPPDWSFPQAAAVPVTFLTAFHGLVDLAGLRAGEKVLIHAAAGGVGIAAVQLARHLGAEVFATASPAKWDAVRALGVDEGHLASSRTGEFEARFAGSGGVDVVLNSLTGELLDASLRLLRPGGRFVEMGKTDIRDAARIAGEHQGVRYRAFDLMDAGPGRIAEMLAEILALFERGRLRPVPVRTWDVRQAPAAFRFLAQARNVGKLVLTMPPAWDPSGTILVTGGYGALGTEVARHLVRTGRARHLLLAGRRGPEAEGMAELTEELRKLGALSVRAVACDMAERASVAELLASVPAEHPLTAVVHTAGVVDDGLLESMTPRRLDTVFRPKADGAWHLHELTRDRELAAFVLFSSAAGTLGAAGQANYAAANAFLDALAAHRRDAGLPATALAWGMWAGTGGMAAALDRAGLDRVSRSGIAGLSTEDGLALFDAALAADRAVWLPIRFHTPALRTAAGQGSLPPLLRGLAGTPADPAAPAGAANALRERLAALAPGERRPAVRELVRGQVAAVLGHPTAETVDPQRPFKELGFDSLTAVELRNRLGAMTGLTLPSTLVFDHPTPDALTDAIEARLPAGPGAPAESFLARLDDWAAGLAAAPLDQDERERVAARLRALALRWEEGTRPQDTGPAVAGELDLATDEEVIDFISNELGIS" }, { "InterPro": [ { "InterPro-ID": "IPR014043", "InterPro-Name": "Acyl_transferase_dom", "InterPro-Type": "DOMAIN", "Beg": 2336, "End": 2656 }, { "InterPro-ID": "IPR014043", "InterPro-Name": "Acyl_transferase_dom", "InterPro-Type": "DOMAIN", "Beg": 564, "End": 881 }, { "InterPro-ID": "IPR006162", "InterPro-Name": "Ppantetheine_attach_site", "InterPro-Type": "PTM", "Beg": 3492, "End": 3507 }, { "InterPro-ID": "IPR016039", "InterPro-Name": "Thiolase-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 25, "End": 476 }, { "InterPro-ID": "IPR016039", "InterPro-Name": "Thiolase-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1801, "End": 2234 }, { "InterPro-ID": "IPR018201", "InterPro-Name": "Ketoacyl_synth_AS", "InterPro-Type": "ACTIVE_SITE", "Beg": 197, "End": 213 }, { "InterPro-ID": "IPR020806", "InterPro-Name": "PKS_PP-bd", "InterPro-Type": "DOMAIN", "Beg": 1725, "End": 1797 }, { "InterPro-ID": "IPR020806", "InterPro-Name": "PKS_PP-bd", "InterPro-Type": "DOMAIN", "Beg": 3465, "End": 3537 }, { "InterPro-ID": "IPR049900", "InterPro-Name": "PKS_mFAS_DH", "InterPro-Type": "DOMAIN", "Beg": 930, "End": 1200 }, { "InterPro-ID": "IPR036736", "InterPro-Name": "ACP-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1721, "End": 1830 }, { "InterPro-ID": "IPR020841", "InterPro-Name": "PKS_Beta-ketoAc_synthase_dom", "InterPro-Type": "DOMAIN", "Beg": 1815, "End": 2231 }, { "InterPro-ID": "IPR014031", "InterPro-Name": "Ketoacyl_synth_C", "InterPro-Type": "DOMAIN", "Beg": 292, "End": 409 }, { "InterPro-ID": "IPR014031", "InterPro-Name": "Ketoacyl_synth_C", "InterPro-Type": "DOMAIN", "Beg": 2064, "End": 2181 }, { "InterPro-ID": "IPR016036", "InterPro-Name": "Malonyl_transacylase_ACP-bd", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 689, "End": 754 }, { "InterPro-ID": "IPR020807", "InterPro-Name": "PKS_DH", "InterPro-Type": "DOMAIN", "Beg": 930, "End": 1092 }, { "InterPro-ID": "IPR020807", "InterPro-Name": "PKS_DH", "InterPro-Type": "DOMAIN", "Beg": 2704, "End": 2868 }, { "InterPro-ID": "IPR016036", "InterPro-Name": "Malonyl_transacylase_ACP-bd", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 2461, "End": 2527 }, { "InterPro-ID": "IPR016035", "InterPro-Name": "Acyl_Trfase/lysoPLipase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 561, "End": 850 }, { "InterPro-ID": "IPR001227", "InterPro-Name": "Ac_transferase_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 2336, "End": 2640 }, { "InterPro-ID": "IPR001227", "InterPro-Name": "Ac_transferase_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 563, "End": 866 }, { "InterPro-ID": "IPR055123", "InterPro-Name": "SpnB-like_Rossmann", "InterPro-Type": "DOMAIN", "Beg": 1332, "End": 1426 }, { "InterPro-ID": "IPR055123", "InterPro-Name": "SpnB-like_Rossmann", "InterPro-Type": "DOMAIN", "Beg": 3064, "End": 3165 }, { "InterPro-ID": "IPR036291", "InterPro-Name": "NAD(P)-bd_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1206, "End": 1430 }, { "InterPro-ID": "IPR006162", "InterPro-Name": "Ppantetheine_attach_site", "InterPro-Type": "PTM", "Beg": 1752, "End": 1767 }, { "InterPro-ID": "IPR016039", "InterPro-Name": "Thiolase-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1811, "End": 2179 }, { "InterPro-ID": "IPR018201", "InterPro-Name": "Ketoacyl_synth_AS", "InterPro-Type": "ACTIVE_SITE", "Beg": 1969, "End": 1985 }, { "InterPro-ID": "IPR009081", "InterPro-Name": "PP-bd_ACP", "InterPro-Type": "DOMAIN", "Beg": 3462, "End": 3537 }, { "InterPro-ID": "IPR036291", "InterPro-Name": "NAD(P)-bd_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1441, "End": 1677 }, { "InterPro-ID": "IPR042104", "InterPro-Name": "PKS_dehydratase_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 2693, "End": 2985 }, { "InterPro-ID": "IPR042104", "InterPro-Name": "PKS_dehydratase_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 919, "End": 1202 }, { "InterPro-ID": "IPR049900", "InterPro-Name": "PKS_mFAS_DH", "InterPro-Type": "DOMAIN", "Beg": 2704, "End": 2981 }, { "InterPro-ID": "IPR016035", "InterPro-Name": "Acyl_Trfase/lysoPLipase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 2334, "End": 2623 }, { "InterPro-ID": "IPR050091", "InterPro-Name": "PKS_NRPS_Biosynth_Enz", "InterPro-Type": "FAMILY", "Beg": 3059, "End": 3170 }, { "InterPro-ID": "IPR049551", "InterPro-Name": "PKS_DH_C", "InterPro-Type": "DOMAIN", "Beg": 1054, "End": 1197 }, { "InterPro-ID": "IPR049551", "InterPro-Name": "PKS_DH_C", "InterPro-Type": "DOMAIN", "Beg": 2837, "End": 2980 }, { "InterPro-ID": "IPR016039", "InterPro-Name": "Thiolase-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 30, "End": 407 }, { "InterPro-ID": "IPR020841", "InterPro-Name": "PKS_Beta-ketoAc_synthase_dom", "InterPro-Type": "DOMAIN", "Beg": 33, "End": 459 }, { "InterPro-ID": "IPR036736", "InterPro-Name": "ACP-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 3458, "End": 3546 }, { "InterPro-ID": "IPR049552", "InterPro-Name": "PKS_DH_N", "InterPro-Type": "DOMAIN", "Beg": 2704, "End": 2804 }, { "InterPro-ID": "IPR049552", "InterPro-Name": "PKS_DH_N", "InterPro-Type": "DOMAIN", "Beg": 930, "End": 1030 }, { "InterPro-ID": "IPR036736", "InterPro-Name": "ACP-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 3442, "End": 3539 }, { "InterPro-ID": "IPR036736", "InterPro-Name": "ACP-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1703, "End": 1800 }, { "InterPro-ID": "IPR014030", "InterPro-Name": "Ketoacyl_synth_N", "InterPro-Type": "DOMAIN", "Beg": 34, "End": 284 }, { "InterPro-ID": "IPR014030", "InterPro-Name": "Ketoacyl_synth_N", "InterPro-Type": "DOMAIN", "Beg": 1816, "End": 2056 }, { "InterPro-ID": "IPR013968", "InterPro-Name": "PKS_KR", "InterPro-Type": "DOMAIN", "Beg": 3182, "End": 3361 }, { "InterPro-ID": "IPR013968", "InterPro-Name": "PKS_KR", "InterPro-Type": "DOMAIN", "Beg": 1443, "End": 1620 }, { "InterPro-ID": "IPR009081", "InterPro-Name": "PP-bd_ACP", "InterPro-Type": "DOMAIN", "Beg": 1727, "End": 1793 }, { "InterPro-ID": "IPR009081", "InterPro-Name": "PP-bd_ACP", "InterPro-Type": "DOMAIN", "Beg": 3467, "End": 3533 }, { "InterPro-ID": "IPR032821", "InterPro-Name": "PKS_assoc", "InterPro-Type": "DOMAIN", "Beg": 412, "End": 528 }, { "InterPro-ID": "IPR032821", "InterPro-Name": "PKS_assoc", "InterPro-Type": "DOMAIN", "Beg": 2184, "End": 2300 }, { "InterPro-ID": "IPR036291", "InterPro-Name": "NAD(P)-bd_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 2987, "End": 3169 }, { "InterPro-ID": "IPR014043", "InterPro-Name": "Acyl_transferase_dom", "InterPro-Type": "DOMAIN", "Beg": 565, "End": 863 }, { "InterPro-ID": "IPR014043", "InterPro-Name": "Acyl_transferase_dom", "InterPro-Type": "DOMAIN", "Beg": 2338, "End": 2637 }, { "InterPro-ID": "IPR036291", "InterPro-Name": "NAD(P)-bd_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 3177, "End": 3430 }, { "InterPro-ID": "IPR020841", "InterPro-Name": "PKS_Beta-ketoAc_synthase_dom", "InterPro-Type": "DOMAIN", "Beg": 36, "End": 462 }, { "InterPro-ID": "IPR020841", "InterPro-Name": "PKS_Beta-ketoAc_synthase_dom", "InterPro-Type": "DOMAIN", "Beg": 1818, "End": 2234 }, { "InterPro-ID": "IPR009081", "InterPro-Name": "PP-bd_ACP", "InterPro-Type": "DOMAIN", "Beg": 1722, "End": 1797 } ], "response#1": "MTKDDKTLDYLKRLTAELVQTRERLRTAQAASREPVAVVSMACRFPGGVSSPEELWRLVAAGRDGITPIPAGRGWDTEGLYDPDPDRVGKSYAREGGFLDDIASFDAGLFGISPREALVMDPQQRLLLEVSRETLERAGIAPGTLGGSRTGVFTGLMGGDYTARLPGILGEFEGQLEIGRAGSVASGRVAYTFGLEGPALTLDTACSSSLVALHLAVRALRDGECDLALAGGATLMSSPAALLEFSRQRALSPDGRCKAFAGQADGTGLAEGVGVVLLERLTDARRNGHPVLAVVRGSAVNQDGASNGLTAPNGPAQQRVIRAALANAGLTAAEVDAVEAHGTGTTLGDPIEAQALLATYGRRRDPQQPLWLGSLKSNIGHTQAAAGIAGVIKTVMALGAGQLPPTLHIDHPTPHVDWSEGTVRLLTEARPWPDTGRPRRVGVSSFGISGTNAHVILEQAEQPPAEDNPSRPLSPVPWVLSAQTPRALRAQAARLRDHLADAPVPHPADIAYSLAVTRDALRHRAVVVGRDPGELLRGVSALADGEPAPGLVEGEAREVGRTVLVFPGQGSQWAGMAQPLWRHSTVFRERMEACAEALAPHVDWSLREMVDAPAEDARWDRVDVVQPVLWAVMVSLAGLWRSHGVEPAAVVGHSQGEIAAACVAGALSLEDGARVVALRSRLVAERLAGKGGMVSVAAPVAEAEDRLARRPGRLALAAVNGPSSVVVSGDPAALEELLADCARDGIRARRVAVDYASHSPQVAALREELLAALAPIRPRAGEIPLYSTVTGGPLAGERLTGEHWYRNLRQTVRLAGTVRTLAAAGHSVFVECSPHPVLTPGLTETLTGLDEDALVVGTLRRDDGGPERFLCSLGELFAGGRAPDWERVFTGTGARRVALPTYAFERRRHWLDAVRPQGDPVPAGLSPLDHPWWGAVTELPEDEGWLLTGRLSRESSPWLGEHTVDGNVLLPGTAFLELALQAAEEAGCAGVAELTLQAPLLLPARGGIRLCAVVGAAGADGTHPLTLHARPEDAPDAPWTRQATGTLTRTARPAEPMPEDWPPPGADPLPVDRIYGELAALSLEYGPAFRGLRAAWRRGEELFAEVALDESGESQGFALHPALLDAALHPVAADEDADGPRLPFSWTGVTLHAVGANRLRVRIGPAGPDAVTLEAADGTGAPVAFVESLAVRPLTPGSGAPAAVTPADSLFAVDWTPAPAAPSATSRTWAVLDGAESLAPAIEAAGCEVLRRPDLTAAIAAPGLPDAMPAARDLGLGERSDAAPGLPDAMLAARDAAPGELSAAVPEPPDVVLAALDPGRGELPAAAREVTGRALALAQRWLAEDGPSRLVLLTRGAVAATGTETADPALAAAWGLLRSAQSEHPDRLVLVDWDGQPSSAAALPAAVSGDEPQLALRGGRILAPRLRRLPVTRPAPQAFDAEGTVLVTGAAGVLGRVITRHLVRTHGVRRLLLVSRRGPEAPGAAELTAELGELGASVRWTACDVADRAALADVLARIPARHPLRAVVHAGGLLDDGVVSALAPDRLETVFRPKIDAVVNLHELTSDLTAFVLFSSAAGTFGTAGQGGYAAANAFLDAFAGLRRSQGLPALSLAWGLWAETSALTARMSDTDRDRMHRSGVTGLSGAEGTALFDAALAAGPPMVLPTRLDLAAVRARAAAEGVPALLRALVKPPARRAGTATESGSALARELAALAPQDRAGAVLETVRAQAAAVLGHTGTAEVEPQRAFKELGFDSLTGVELRNRLARVTGLRLPATLVFDHPTPHSLAAHLLGRLTGGQRPRSTAPHAPARPDEPIAIIGMACRFPGGIASPEDLWRLLERGGDAISAFPADRGWDLDPAEYTAEGGFLREAARFDPEFFGISPREAVAMDPQQRLLLEITWEALERAGLDPTALRGSRTGVFAGLMYHDYTVRHAAAPGEAAGYLGTGGSGSVASGRIAYTFGFEGPAVTVDTACSSSLVALHLAAQSVRAGDCELALAGGVTVMCTPSAFTEFSRQGALAADARCKPFAAAADGTVWGEGAGVLLVERLSEAQRQGHRVLAVLRGSAVNQDGASNGLTAPNGPSQERVIRHALATARLRARDVDAVEAHGTGTTLGDPIEAQALLATYGQDRPAGRPLWLGSVKSNLGHPQAAAGVAGVIKVVLALRQGVLPRTLHVDRPTPQVDWSQGAVELLTEARPWPETGRPRRAAVSSFGISGTNAHVVLEQAPAPAEHDPQPAAVPGPLPLVLSARGEPALRAQAAGLRERLTADPGLQLADVAGSLLTTRAALEHRAVVLGDGRAELLAGLAALAHGRETPAVVRGTACAPGKTVFVFPGQGAQWPGMAAELWESSPVFRKRLGECAEALAPWVDFDAVEVVRGTATGIDPERVDVVQPALWAVMVALAGLWRSYGVEPAAVVGHSQGEIAAACVAGGLTLADGARVVALRSRALTALAGRGGMLSLALTPAEAGKLVAGRGDDRLSLAAVNGPESVVVSGDTDALEEVLAHCERTGVWARRIPVDYASHSPQVAEVRAHIQRDLAELRPRTGQVAFFSTVTGRFEDTAGLDGDYWYRNLREPVRFEPAVRELAGLGFGAFVETSPHPVLTTAVGEALAGRPGPPPVVVGSLRRGQGGPLRFLASVAEAHTRGIAVDWSTLWAGRTPRVVDLPTYPFQRRRFWLPAPAASGEVTAAGLGRAEHPLLGARMELADPPETVLTARWSLDTHPWIADHTVADTVIVPGTAFLELALLAGAETGCPQVRELIQQAPLVLAERGAARLQMRIAPPAEDGTRALAIHSRPEDASPEEPWLCHARGLLSEEEPATPPALDGSWPPPGAEPIELVGFYQHLDEIGLGYGPAFRGLRAAWRLGEEILAEAALPEPQQDETAGYRAHPALLDAALHSCLLRGRGERPEAAAMPFAWNDVACHADCGPAVRVRVTPGAGQEVSVVVADVQGSPAVTIRSLAARPVPAGQLRAAGGRSGSLFHLTWTPAPTDTGASPGAWAVLGEDDPGLALPYFPGLPALWAAYDGGATAPELVLAPLAGGPGDGPERSRELTCRALELLQSWLADDRTETRRLVIVTRGAVTASDDDPPPDPAAAAVWGLVRSAQSEHPGRFLLADLDRHPDSAPALTAALATALALDEPQLALRAGRVLLPRIQRAPAAQEGTPPWDPQGTVLITGASGTLGRAVARHLVTTHGVRRLLLVGRHGGAGEEAARLTTELAGHQATVDWAACDAADREAIAAVLASIPAAHPLTAVIHAAGVLDDGVLPALSPQRIDAVFRPKADAARHLDALTRTASPPALVVFSSAAATLGSAGQANYAAANAFLDALILARRRAGFPGQSLAWGLWSETSEMTAALGQAGRARLARSGLQGMPTEEALALLDTALATDRPLLLPMRLDPPALREGAGPLPPVLRGLVRAPARRGGPGRAEDAAALRRRLAALTPAERDRQLTDLVRAQAATVLGHPGAEAVGRDRAFKELGFDSLTAVELRNRLSTATGLRLPPTLVFDHPTPAALAGHLSTRLAPDDDPPDAPHDSEREVRRALAAIPLTRLRDAGLLDALLELAGRPAAGAAPPDDGEPGSIDRLDAEGLLAMALNNQAHAETEDHDAGW", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Acyl_transferase_dom, Acyl_transferase_dom, PKS_PP-bd, PKS_PP-bd, PKS_mFAS_DH, PKS_Beta-ketoAc_synthase_dom, Ketoacyl_synth_C, Ketoacyl_synth_C, PKS_DH, PKS_DH, SpnB-like_Rossmann, SpnB-like_Rossmann, PP-bd_ACP, PKS_mFAS_DH, PKS_DH_C, PKS_DH_C, PKS_Beta-ketoAc_synthase_dom, PKS_DH_N, PKS_DH_N, Ketoacyl_synth_N, Ketoacyl_synth_N, PKS_KR, PKS_KR, PP-bd_ACP, PP-bd_ACP, PKS_assoc, PKS_assoc, Acyl_transferase_dom, Acyl_transferase_dom, PKS_Beta-ketoAc_synthase_dom, PKS_Beta-ketoAc_synthase_dom, PP-bd_ACP that are essential for its biological function; 2. The protein should belong to PKS_NRPS_Biosynth_Enz that shares evolutionary origin and functional similarity; 3. The protein should be classified within Thiolase-like, Thiolase-like, ACP-like_sf, Malonyl_transacylase_ACP-bd, Malonyl_transacylase_ACP-bd, Acyl_Trfase/lysoPLipase, Ac_transferase_dom_sf, Ac_transferase_dom_sf, NAD(P)-bd_dom_sf, Thiolase-like, NAD(P)-bd_dom_sf, PKS_dehydratase_sf, PKS_dehydratase_sf, Acyl_Trfase/lysoPLipase, Thiolase-like, ACP-like_sf, ACP-like_sf, ACP-like_sf, NAD(P)-bd_dom_sf, NAD(P)-bd_dom_sf sharing conserved structural features; 4. The protein must have Ketoacyl_synth_AS, Ketoacyl_synth_AS that is conserved among related catalytic enzymes; 5. The protein should contain Ppantetheine_attach_site, Ppantetheine_attach_site that allow regulation through chemical modifications. The designed protein sequence is ", "reference": "MTKDDKTLDYLKRLTAELVQTRERLRTAQAASREPVAVVSMACRFPGGVSSPEELWRLVAAGRDGITPIPAGRGWDTEGLYDPDPDRVGKSYAREGGFLDDIASFDAGLFGISPREALVMDPQQRLLLEVSRETLERAGIAPGTLGGSRTGVFTGLMGGDYTARLPGILGEFEGQLEIGRAGSVASGRVAYTFGLEGPALTLDTACSSSLVALHLAVRALRDGECDLALAGGATLMSSPAALLEFSRQRALSPDGRCKAFAGQADGTGLAEGVGVVLLERLTDARRNGHPVLAVVRGSAVNQDGASNGLTAPNGPAQQRVIRAALANAGLTAAEVDAVEAHGTGTTLGDPIEAQALLATYGRRRDPQQPLWLGSLKSNIGHTQAAAGIAGVIKTVMALGAGQLPPTLHIDHPTPHVDWSEGTVRLLTEARPWPDTGRPRRVGVSSFGISGTNAHVILEQAEQPPAEDNPSRPLSPVPWVLSAQTPRALRAQAARLRDHLADAPVPHPADIAYSLAVTRDALRHRAVVVGRDPGELLRGVSALADGEPAPGLVEGEAREVGRTVLVFPGQGSQWAGMAQPLWRHSTVFRERMEACAEALAPHVDWSLREMVDAPAEDARWDRVDVVQPVLWAVMVSLAGLWRSHGVEPAAVVGHSQGEIAAACVAGALSLEDGARVVALRSRLVAERLAGKGGMVSVAAPVAEAEDRLARRPGRLALAAVNGPSSVVVSGDPAALEELLADCARDGIRARRVAVDYASHSPQVAALREELLAALAPIRPRAGEIPLYSTVTGGPLAGERLTGEHWYRNLRQTVRLAGTVRTLAAAGHSVFVECSPHPVLTPGLTETLTGLDEDALVVGTLRRDDGGPERFLCSLGELFAGGRAPDWERVFTGTGARRVALPTYAFERRRHWLDAVRPQGDPVPAGLSPLDHPWWGAVTELPEDEGWLLTGRLSRESSPWLGEHTVDGNVLLPGTAFLELALQAAEEAGCAGVAELTLQAPLLLPARGGIRLCAVVGAAGADGTHPLTLHARPEDAPDAPWTRQATGTLTRTARPAEPMPEDWPPPGADPLPVDRIYGELAALSLEYGPAFRGLRAAWRRGEELFAEVALDESGESQGFALHPALLDAALHPVAADEDADGPRLPFSWTGVTLHAVGANRLRVRIGPAGPDAVTLEAADGTGAPVAFVESLAVRPLTPGSGAPAAVTPADSLFAVDWTPAPAAPSATSRTWAVLDGAESLAPAIEAAGCEVLRRPDLTAAIAAPGLPDAMPAARDLGLGERSDAAPGLPDAMLAARDAAPGELSAAVPEPPDVVLAALDPGRGELPAAAREVTGRALALAQRWLAEDGPSRLVLLTRGAVAATGTETADPALAAAWGLLRSAQSEHPDRLVLVDWDGQPSSAAALPAAVSGDEPQLALRGGRILAPRLRRLPVTRPAPQAFDAEGTVLVTGAAGVLGRVITRHLVRTHGVRRLLLVSRRGPEAPGAAELTAELGELGASVRWTACDVADRAALADVLARIPARHPLRAVVHAGGLLDDGVVSALAPDRLETVFRPKIDAVVNLHELTSDLTAFVLFSSAAGTFGTAGQGGYAAANAFLDAFAGLRRSQGLPALSLAWGLWAETSALTARMSDTDRDRMHRSGVTGLSGAEGTALFDAALAAGPPMVLPTRLDLAAVRARAAAEGVPALLRALVKPPARRAGTATESGSALARELAALAPQDRAGAVLETVRAQAAAVLGHTGTAEVEPQRAFKELGFDSLTGVELRNRLARVTGLRLPATLVFDHPTPHSLAAHLLGRLTGGQRPRSTAPHAPARPDEPIAIIGMACRFPGGIASPEDLWRLLERGGDAISAFPADRGWDLDPAEYTAEGGFLREAARFDPEFFGISPREAVAMDPQQRLLLEITWEALERAGLDPTALRGSRTGVFAGLMYHDYTVRHAAAPGEAAGYLGTGGSGSVASGRIAYTFGFEGPAVTVDTACSSSLVALHLAAQSVRAGDCELALAGGVTVMCTPSAFTEFSRQGALAADARCKPFAAAADGTVWGEGAGVLLVERLSEAQRQGHRVLAVLRGSAVNQDGASNGLTAPNGPSQERVIRHALATARLRARDVDAVEAHGTGTTLGDPIEAQALLATYGQDRPAGRPLWLGSVKSNLGHPQAAAGVAGVIKVVLALRQGVLPRTLHVDRPTPQVDWSQGAVELLTEARPWPETGRPRRAAVSSFGISGTNAHVVLEQAPAPAEHDPQPAAVPGPLPLVLSARGEPALRAQAAGLRERLTADPGLQLADVAGSLLTTRAALEHRAVVLGDGRAELLAGLAALAHGRETPAVVRGTACAPGKTVFVFPGQGAQWPGMAAELWESSPVFRKRLGECAEALAPWVDFDAVEVVRGTATGIDPERVDVVQPALWAVMVALAGLWRSYGVEPAAVVGHSQGEIAAACVAGGLTLADGARVVALRSRALTALAGRGGMLSLALTPAEAGKLVAGRGDDRLSLAAVNGPESVVVSGDTDALEEVLAHCERTGVWARRIPVDYASHSPQVAEVRAHIQRDLAELRPRTGQVAFFSTVTGRFEDTAGLDGDYWYRNLREPVRFEPAVRELAGLGFGAFVETSPHPVLTTAVGEALAGRPGPPPVVVGSLRRGQGGPLRFLASVAEAHTRGIAVDWSTLWAGRTPRVVDLPTYPFQRRRFWLPAPAASGEVTAAGLGRAEHPLLGARMELADPPETVLTARWSLDTHPWIADHTVADTVIVPGTAFLELALLAGAETGCPQVRELIQQAPLVLAERGAARLQMRIAPPAEDGTRALAIHSRPEDASPEEPWLCHARGLLSEEEPATPPALDGSWPPPGAEPIELVGFYQHLDEIGLGYGPAFRGLRAAWRLGEEILAEAALPEPQQDETAGYRAHPALLDAALHSCLLRGRGERPEAAAMPFAWNDVACHADCGPAVRVRVTPGAGQEVSVVVADVQGSPAVTIRSLAARPVPAGQLRAAGGRSGSLFHLTWTPAPTDTGASPGAWAVLGEDDPGLALPYFPGLPALWAAYDGGATAPELVLAPLAGGPGDGPERSRELTCRALELLQSWLADDRTETRRLVIVTRGAVTASDDDPPPDPAAAAVWGLVRSAQSEHPGRFLLADLDRHPDSAPALTAALATALALDEPQLALRAGRVLLPRIQRAPAAQEGTPPWDPQGTVLITGASGTLGRAVARHLVTTHGVRRLLLVGRHGGAGEEAARLTTELAGHQATVDWAACDAADREAIAAVLASIPAAHPLTAVIHAAGVLDDGVLPALSPQRIDAVFRPKADAARHLDALTRTASPPALVVFSSAAATLGSAGQANYAAANAFLDALILARRRAGFPGQSLAWGLWSETSEMTAALGQAGRARLARSGLQGMPTEEALALLDTALATDRPLLLPMRLDPPALREGAGPLPPVLRGLVRAPARRGGPGRAEDAAALRRRLAALTPAERDRQLTDLVRAQAATVLGHPGAEAVGRDRAFKELGFDSLTAVELRNRLSTATGLRLPPTLVFDHPTPAALAGHLSTRLAPDDDPPDAPHDSEREVRRALAAIPLTRLRDAGLLDALLELAGRPAAGAAPPDDGEPGSIDRLDAEGLLAMALNNQAHAETEDHDAGW" }, { "InterPro": [ { "InterPro-ID": "IPR049900", "InterPro-Name": "PKS_mFAS_DH", "InterPro-Type": "DOMAIN", "Beg": 1012, "End": 1289 }, { "InterPro-ID": "IPR016039", "InterPro-Name": "Thiolase-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 109, "End": 535 }, { "InterPro-ID": "IPR036291", "InterPro-Name": "NAD(P)-bd_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1492, "End": 1707 }, { "InterPro-ID": "IPR036736", "InterPro-Name": "ACP-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 5, "End": 97 }, { "InterPro-ID": "IPR014031", "InterPro-Name": "Ketoacyl_synth_C", "InterPro-Type": "DOMAIN", "Beg": 369, "End": 486 }, { "InterPro-ID": "IPR009081", "InterPro-Name": "PP-bd_ACP", "InterPro-Type": "DOMAIN", "Beg": 1777, "End": 1852 }, { "InterPro-ID": "IPR014043", "InterPro-Name": "Acyl_transferase_dom", "InterPro-Type": "DOMAIN", "Beg": 645, "End": 943 }, { "InterPro-ID": "IPR049551", "InterPro-Name": "PKS_DH_C", "InterPro-Type": "DOMAIN", "Beg": 1141, "End": 1288 }, { "InterPro-ID": "IPR042104", "InterPro-Name": "PKS_dehydratase_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1002, "End": 1290 }, { "InterPro-ID": "IPR020807", "InterPro-Name": "PKS_DH", "InterPro-Type": "DOMAIN", "Beg": 1012, "End": 1177 }, { "InterPro-ID": "IPR018201", "InterPro-Name": "Ketoacyl_synth_AS", "InterPro-Type": "ACTIVE_SITE", "Beg": 274, "End": 290 }, { "InterPro-ID": "IPR020841", "InterPro-Name": "PKS_Beta-ketoAc_synthase_dom", "InterPro-Type": "DOMAIN", "Beg": 115, "End": 539 }, { "InterPro-ID": "IPR049552", "InterPro-Name": "PKS_DH_N", "InterPro-Type": "DOMAIN", "Beg": 1012, "End": 1113 }, { "InterPro-ID": "IPR036736", "InterPro-Name": "ACP-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1773, "End": 1862 }, { "InterPro-ID": "IPR036736", "InterPro-Name": "ACP-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1760, "End": 1852 }, { "InterPro-ID": "IPR036736", "InterPro-Name": "ACP-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 18, "End": 127 }, { "InterPro-ID": "IPR020841", "InterPro-Name": "PKS_Beta-ketoAc_synthase_dom", "InterPro-Type": "DOMAIN", "Beg": 112, "End": 536 }, { "InterPro-ID": "IPR016035", "InterPro-Name": "Acyl_Trfase/lysoPLipase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 641, "End": 930 }, { "InterPro-ID": "IPR014043", "InterPro-Name": "Acyl_transferase_dom", "InterPro-Type": "DOMAIN", "Beg": 644, "End": 962 }, { "InterPro-ID": "IPR014030", "InterPro-Name": "Ketoacyl_synth_N", "InterPro-Type": "DOMAIN", "Beg": 113, "End": 361 }, { "InterPro-ID": "IPR009081", "InterPro-Name": "PP-bd_ACP", "InterPro-Type": "DOMAIN", "Beg": 1783, "End": 1848 }, { "InterPro-ID": "IPR006162", "InterPro-Name": "Ppantetheine_attach_site", "InterPro-Type": "PTM", "Beg": 1807, "End": 1822 }, { "InterPro-ID": "IPR036291", "InterPro-Name": "NAD(P)-bd_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1296, "End": 1480 }, { "InterPro-ID": "IPR016036", "InterPro-Name": "Malonyl_transacylase_ACP-bd", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 768, "End": 833 }, { "InterPro-ID": "IPR050091", "InterPro-Name": "PKS_NRPS_Biosynth_Enz", "InterPro-Type": "FAMILY", "Beg": 1483, "End": 1848 }, { "InterPro-ID": "IPR032821", "InterPro-Name": "PKS_assoc", "InterPro-Type": "DOMAIN", "Beg": 489, "End": 586 }, { "InterPro-ID": "IPR001227", "InterPro-Name": "Ac_transferase_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 643, "End": 946 }, { "InterPro-ID": "IPR055123", "InterPro-Name": "SpnB-like_Rossmann", "InterPro-Type": "DOMAIN", "Beg": 1360, "End": 1476 }, { "InterPro-ID": "IPR013968", "InterPro-Name": "PKS_KR", "InterPro-Type": "DOMAIN", "Beg": 1494, "End": 1671 }, { "InterPro-ID": "IPR016039", "InterPro-Name": "Thiolase-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 104, "End": 552 }, { "InterPro-ID": "IPR020806", "InterPro-Name": "PKS_PP-bd", "InterPro-Type": "DOMAIN", "Beg": 23, "End": 95 }, { "InterPro-ID": "IPR020806", "InterPro-Name": "PKS_PP-bd", "InterPro-Type": "DOMAIN", "Beg": 1780, "End": 1852 } ], "response#1": "MELNGIRRRLATAKEAERHRLLLELIRAAAAEALDRPGPLPLDPGRAFGAQGVRGRAAGRLRERLSEATGLPLPATVVFDYPTPGALAGRLCALLLDEPAGPGGANGQMEAEEPIAIVGMGCRLPGDVRSPEGLWRLVHNGTDAISEFPEDRGWTVQQHPDPDHLGTTVTRHAGFLYDAPDFDAGFFAISPGEAVTIDPQHRLLLETTWKAVEDARIDPTSLRGSRTGVFVGLMYSEYGARIRRVPPGAEGYRVVGSMPSVASGRLAYTFGFEGPAVTVDTACSSSLVAMHLAAQSLRKGECTLAVAGGATVMATPWGYIEFSRQRGLAPDGRCRSFSADAAGSSWSEGVGVLLLERLSDARRHGHRVLAVVRGSAVNQDGASNGLTAPNGPAQQRVIRQALAHAGLTTAEVDAVDAHGAGTRLGDPIEAQALLATYGQGRPAGRPLWLGSLKSNIGHTQAAAGAAGVIKMVMAMRHGVLPRSLHITEPTPHVDWTSGAVELLTEARDWPADGRPRRAAVSSFGVGGTNAHIILEQAAPEPERPHAPEADGEPRPLPWPVSGHGAAGLRAQARRLADFLRAGPAAPDADLAYSLATTRATLTDRAVVVAADRAEAIARLTALAEGDQGPRVARATAVPRDRLAFVFPGQGSQWPGMAAELMSCYPVFRESIKECGRSLAPHTDWSLAKVLRGESGAPTLDRVDVVQPALFAVMVSLAALWRSFGVEPSAVAGHSQGEIAAARVAGALSLEDAARVVALRSRALRVLSGRGGMVSVAAPAGQVLRTLERWGGAVSVAAVNGPRSLVISGDPGALGEALAAFEAEGIRARRIPVDYASHSAQVEEIRDTLLTELSGIRPRPATVPFYSTVSGEPLDTTALDTGYWVRNLRDTVQFDRTVRRLLADGHTTFLEMSPHPVLTPGIQETAEEAGADEVLTVESLRRNEGGPARLLTAVAEAHVHGVAVDWSPAFAPHRSPARRPAVLRLSSGAATGLRTRPRPPPMFTTAGLDGIDHPLLGAAIPLADGGGGTLFTGTLSLATHPWLADHAVADVLVVPGTALVEAALRAGAECTGRAMLEELVLQAPLILPEQGTVRIQLSVGGPDGTGRRALILSSRPEDAGADEPWTRHAEGTLAPGGGHPRQDPGPWPPTGAREIDLDDCYRQLAKTGLHYGPAFQGLKRLWRLADDLCLEAELPDSAGESGRYGLHPALFDAALHAAALAGPSGAEPLTRLPFSWSGVALYTAGATRLRARLSFTGPQSLTLTAMDPLGHPVLSVGTLGMRPVTAEALHRAAGTAGTALLRLEWRRQAPEHPAGPDLTGWAWVGAGAPPAQPPDGRPYRDLAALRAELDAGAAVPPVIVLAEPATPEGTDPFTAARAALHRTLAAIQDWAAEERLAGTRLVVLTQGAVAATPGALPDPALAAVWGLVRSAQAEYPDRIGLVDTDDPGRSRAAVAAAVHAGEAQAAVRDGALLVPRLARVTATDGPGGPAWPADGTVLVTGGLGTLGRLVVRHLVTTHGARRLVILSRSGGDSAEVREFVGELLAQGANVQVVKGDAADPAVLERVLDGIPQEHPLAAVAHLAGALDDGVLAAQTPQRLDRVLRPKAEAAWQLHRLTARARVPLLAFSSLSGVLGPAGQAGYAAANAFVDALVQRRRGTGLPGVSMGWGMWATRSGLTGALSDTDARLIARTGVRPLTDEEGLALFDQARATGEPVVFPLGLDITALNSGAPDGIPPLLRGLTARTPARRAGAAEAPEPAGEDLAARLAATPEAERDALLLGVVRGHIAAVLGYDDPRAVAERRPFSDIGFDSLRALQLRNRLGAATGRRLPATLVFDHPNPAALSRYLRTLLLPDPAPAPTAPDGQPGPDQADQVIERLNSASLEEVLDFIDHQLGE", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more PKS_mFAS_DH, Ketoacyl_synth_C, PP-bd_ACP, Acyl_transferase_dom, PKS_DH_C, PKS_DH, PKS_Beta-ketoAc_synthase_dom, PKS_DH_N, PKS_Beta-ketoAc_synthase_dom, Acyl_transferase_dom, Ketoacyl_synth_N, PP-bd_ACP, PKS_assoc, SpnB-like_Rossmann, PKS_KR, PKS_PP-bd, PKS_PP-bd that are essential for its biological function; 2. The protein should belong to PKS_NRPS_Biosynth_Enz that shares evolutionary origin and functional similarity; 3. The protein should be classified within Thiolase-like, NAD(P)-bd_dom_sf, ACP-like_sf, PKS_dehydratase_sf, ACP-like_sf, ACP-like_sf, ACP-like_sf, Acyl_Trfase/lysoPLipase, NAD(P)-bd_dom_sf, Malonyl_transacylase_ACP-bd, Ac_transferase_dom_sf, Thiolase-like sharing conserved structural features; 4. The protein must have Ketoacyl_synth_AS that is conserved among related catalytic enzymes; 5. The protein should contain Ppantetheine_attach_site that allow regulation through chemical modifications. The designed protein sequence is ", "reference": "MELNGIRRRLATAKEAERHRLLLELIRAAAAEALDRPGPLPLDPGRAFGAQGVRGRAAGRLRERLSEATGLPLPATVVFDYPTPGALAGRLCALLLDEPAGPGGANGQMEAEEPIAIVGMGCRLPGDVRSPEGLWRLVHNGTDAISEFPEDRGWTVQQHPDPDHLGTTVTRHAGFLYDAPDFDAGFFAISPGEAVTIDPQHRLLLETTWKAVEDARIDPTSLRGSRTGVFVGLMYSEYGARIRRVPPGAEGYRVVGSMPSVASGRLAYTFGFEGPAVTVDTACSSSLVAMHLAAQSLRKGECTLAVAGGATVMATPWGYIEFSRQRGLAPDGRCRSFSADAAGSSWSEGVGVLLLERLSDARRHGHRVLAVVRGSAVNQDGASNGLTAPNGPAQQRVIRQALAHAGLTTAEVDAVDAHGAGTRLGDPIEAQALLATYGQGRPAGRPLWLGSLKSNIGHTQAAAGAAGVIKMVMAMRHGVLPRSLHITEPTPHVDWTSGAVELLTEARDWPADGRPRRAAVSSFGVGGTNAHIILEQAAPEPERPHAPEADGEPRPLPWPVSGHGAAGLRAQARRLADFLRAGPAAPDADLAYSLATTRATLTDRAVVVAADRAEAIARLTALAEGDQGPRVARATAVPRDRLAFVFPGQGSQWPGMAAELMSCYPVFRESIKECGRSLAPHTDWSLAKVLRGESGAPTLDRVDVVQPALFAVMVSLAALWRSFGVEPSAVAGHSQGEIAAARVAGALSLEDAARVVALRSRALRVLSGRGGMVSVAAPAGQVLRTLERWGGAVSVAAVNGPRSLVISGDPGALGEALAAFEAEGIRARRIPVDYASHSAQVEEIRDTLLTELSGIRPRPATVPFYSTVSGEPLDTTALDTGYWVRNLRDTVQFDRTVRRLLADGHTTFLEMSPHPVLTPGIQETAEEAGADEVLTVESLRRNEGGPARLLTAVAEAHVHGVAVDWSPAFAPHRSPARRPAVLRLSSGAATGLRTRPRPPPMFTTAGLDGIDHPLLGAAIPLADGGGGTLFTGTLSLATHPWLADHAVADVLVVPGTALVEAALRAGAECTGRAMLEELVLQAPLILPEQGTVRIQLSVGGPDGTGRRALILSSRPEDAGADEPWTRHAEGTLAPGGGHPRQDPGPWPPTGAREIDLDDCYRQLAKTGLHYGPAFQGLKRLWRLADDLCLEAELPDSAGESGRYGLHPALFDAALHAAALAGPSGAEPLTRLPFSWSGVALYTAGATRLRARLSFTGPQSLTLTAMDPLGHPVLSVGTLGMRPVTAEALHRAAGTAGTALLRLEWRRQAPEHPAGPDLTGWAWVGAGAPPAQPPDGRPYRDLAALRAELDAGAAVPPVIVLAEPATPEGTDPFTAARAALHRTLAAIQDWAAEERLAGTRLVVLTQGAVAATPGALPDPALAAVWGLVRSAQAEYPDRIGLVDTDDPGRSRAAVAAAVHAGEAQAAVRDGALLVPRLARVTATDGPGGPAWPADGTVLVTGGLGTLGRLVVRHLVTTHGARRLVILSRSGGDSAEVREFVGELLAQGANVQVVKGDAADPAVLERVLDGIPQEHPLAAVAHLAGALDDGVLAAQTPQRLDRVLRPKAEAAWQLHRLTARARVPLLAFSSLSGVLGPAGQAGYAAANAFVDALVQRRRGTGLPGVSMGWGMWATRSGLTGALSDTDARLIARTGVRPLTDEEGLALFDQARATGEPVVFPLGLDITALNSGAPDGIPPLLRGLTARTPARRAGAAEAPEPAGEDLAARLAATPEAERDALLLGVVRGHIAAVLGYDDPRAVAERRPFSDIGFDSLRALQLRNRLGAATGRRLPATLVFDHPNPAALSRYLRTLLLPDPAPAPTAPDGQPGPDQADQVIERLNSASLEEVLDFIDHQLGE" }, { "InterPro": [ { "InterPro-ID": "IPR036291", "InterPro-Name": "NAD(P)-bd_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 2, "End": 318 }, { "InterPro-ID": "IPR044516", "InterPro-Name": "UXS-like", "InterPro-Type": "FAMILY", "Beg": 2, "End": 317 }, { "InterPro-ID": "IPR001509", "InterPro-Name": "Epimerase_deHydtase", "InterPro-Type": "DOMAIN", "Beg": 6, "End": 242 } ], "response#1": "MKKRCLITGGAGFIGSHLAEELVKRGHPVTIVDNFYKGKSKYHEELTGNIPIIPISILDKNSMHELVNQHDVVFHLAAILGVKTTMEKSIELIETNFDGTRNILQAALKGKKKVIFASTSEVYGKGTPPFSEDDDRLYGATSKIRWSYAICKTLEETLCLGYALQGLPVTIVRYFNIYGPRAKDGPYAGVIPRFIRAALQGDDLLVYGDGKQTRCFTYVSDAVEATIAAMDEKVNGEIINIGSEDEKSIQEVAQDIHQLTHSSSKIVHVPFEKVYPHGFEEIPNRKPDVTKLKEMCQFHPNVSWEQGLKETIQWFREIEND", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Epimerase_deHydtase that are essential for its biological function; 2. The protein should belong to UXS-like that shares evolutionary origin and functional similarity; 3. The protein should be classified within NAD(P)-bd_dom_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MKKRCLITGGAGFIGSHLAEELVKRGHPVTIVDNFYKGKSKYHEELTGNIPIIPISILDKNSMHELVNQHDVVFHLAAILGVKTTMEKSIELIETNFDGTRNILQAALKGKKKVIFASTSEVYGKGTPPFSEDDDRLYGATSKIRWSYAICKTLEETLCLGYALQGLPVTIVRYFNIYGPRAKDGPYAGVIPRFIRAALQGDDLLVYGDGKQTRCFTYVSDAVEATIAAMDEKVNGEIINIGSEDEKSIQEVAQDIHQLTHSSSKIVHVPFEKVYPHGFEEIPNRKPDVTKLKEMCQFHPNVSWEQGLKETIQWFREIEND" }, { "InterPro": [ { "InterPro-ID": "IPR021848", "InterPro-Name": "HODM_asu-like", "InterPro-Type": "FAMILY", "Beg": 54, "End": 327 } ], "response#1": "MTLTFKPLESYREDFSFRNSPAAIARFPFPFPEDQYMYSVNLEPAVSRDPGSVFEHQFDVDEHYVSEMAERARVLELDPGRCLVMPHMAQAAWDTLAMLMEHLARDYPQHFRLTRQGDAWHWQNLALGIDQRFTFGDPASLPCEPLEYITRQMQGDFAVLDQRDGDLFMDAGMVTCPADWSLRFDAGMSFKQWHSPVPMAHQMGVFDRALKYLLNIQVGAPVRRLNWTLTINPRLDTSPETYHEWGNDRGKVTPDNVGRLVHLRVELQLMARLPRSNALLFGIRTYLISLDELVSNPAWAQRLHRVMRDLPDPIADYKGITRYRQTLVDWLRRFDPEA", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to HODM_asu-like that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MTLTFKPLESYREDFSFRNSPAAIARFPFPFPEDQYMYSVNLEPAVSRDPGSVFEHQFDVDEHYVSEMAERARVLELDPGRCLVMPHMAQAAWDTLAMLMEHLARDYPQHFRLTRQGDAWHWQNLALGIDQRFTFGDPASLPCEPLEYITRQMQGDFAVLDQRDGDLFMDAGMVTCPADWSLRFDAGMSFKQWHSPVPMAHQMGVFDRALKYLLNIQVGAPVRRLNWTLTINPRLDTSPETYHEWGNDRGKVTPDNVGRLVHLRVELQLMARLPRSNALLFGIRTYLISLDELVSNPAWAQRLHRVMRDLPDPIADYKGITRYRQTLVDWLRRFDPEA" }, { "InterPro": [ { "InterPro-ID": "IPR048037", "InterPro-Name": "DmmA-like_C", "InterPro-Type": "DOMAIN", "Beg": 120, "End": 162 } ], "response#1": "MSSAATNHPFSVPRYPSGQTCPAASEHLLVTQGAGQEERDALAAQLGKVRITHLALPDFPSVADLQLVLSTTLKDARVGLRLDLRGDEAFVWPLHALARAAGLLADEIFMSSSPEGTRLVFCVHCATCQPATSAGHLTCTQCGVMLEVRRHFSQRLGAYLGVCADADQPYQGVQP", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more DmmA-like_C that are essential for its biological function. The designed protein sequence is ", "reference": "MSSAATNHPFSVPRYPSGQTCPAASEHLLVTQGAGQEERDALAAQLGKVRITHLALPDFPSVADLQLVLSTTLKDARVGLRLDLRGDEAFVWPLHALARAAGLLADEIFMSSSPEGTRLVFCVHCATCQPATSAGHLTCTQCGVMLEVRRHFSQRLGAYLGVCADADQPYQGVQP" }, { "InterPro": [ { "InterPro-ID": "IPR013783", "InterPro-Name": "Ig-like_fold", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 89, "End": 180 }, { "InterPro-ID": "IPR039293", "InterPro-Name": "TMEM81", "InterPro-Type": "FAMILY", "Beg": 3, "End": 250 }, { "InterPro-ID": "IPR036179", "InterPro-Name": "Ig-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 88, "End": 164 }, { "InterPro-ID": "IPR007110", "InterPro-Name": "Ig-like_dom", "InterPro-Type": "DOMAIN", "Beg": 97, "End": 172 } ], "response#1": "MALSTLWLVLMLWTSLFSDSQCSTLSQAELQELEQIHTWVVSRSFPCSVTCGLGLLTQELCPIGVTRNISTSSCKLRTISCLDSWQCGLKTQTATVGRRLVLDCLEEVMEAMGRFSFVVSWRFAFAIITTDDSLFTRYEALSLDKVVLDPLREEDSGTYRCDVLDTGKRRVKRMYKGVKVLSPKDLSLDFAQGLIHWEIPESRFANLTSSRKVYSSSTIRNIVIISVPLSFAIAVVIFIFLFCYSRRARRAAHLCQDNI", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Ig-like_dom that are essential for its biological function; 2. The protein should belong to TMEM81 that shares evolutionary origin and functional similarity; 3. The protein should be classified within Ig-like_fold, Ig-like_dom_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MALSTLWLVLMLWTSLFSDSQCSTLSQAELQELEQIHTWVVSRSFPCSVTCGLGLLTQELCPIGVTRNISTSSCKLRTISCLDSWQCGLKTQTATVGRRLVLDCLEEVMEAMGRFSFVVSWRFAFAIITTDDSLFTRYEALSLDKVVLDPLREEDSGTYRCDVLDTGKRRVKRMYKGVKVLSPKDLSLDFAQGLIHWEIPESRFANLTSSRKVYSSSTIRNIVIISVPLSFAIAVVIFIFLFCYSRRARRAAHLCQDNI" }, { "InterPro": [ { "InterPro-ID": "IPR029043", "InterPro-Name": "GcvT/YgfZ_C", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 290, "End": 372 }, { "InterPro-ID": "IPR028896", "InterPro-Name": "GcvT/YgfZ/DmdA", "InterPro-Type": "FAMILY", "Beg": 6, "End": 370 }, { "InterPro-ID": "IPR027266", "InterPro-Name": "TrmE/GcvT_dom1", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 5, "End": 374 }, { "InterPro-ID": "IPR013977", "InterPro-Name": "GCST_C", "InterPro-Type": "DOMAIN", "Beg": 291, "End": 364 }, { "InterPro-ID": "IPR006222", "InterPro-Name": "GCV_T_N", "InterPro-Type": "DOMAIN", "Beg": 10, "End": 242 } ], "response#1": "MANSWRISALRERHLALGSQLEDWNGMGTAWTYASDLADHHEAIRTRAGLMDVSGLKKVHYVGPHAESLLDYATTRDIGKLYPGKSVYACLLDEDGKFIDDCIVYRTGPNAFMVVHGAGTGHEMLIRSAQGRQVAVLFDDDLHDLSLQGPRAVDFLAEHVPGIRDLPYFHHLQTKLFDRPVMISRTGYTGERGYEIFCKAADAPAIWDAILEQGKGYGIIPCAFTALDWLRVESYLLFFPYDNSQMYPFADQKAGDTLWELGLDFTVSPGKQDFRGAGEHYRLKGQERFKIFGVLLDGHQAAQGGDTLWHDGRQVGVITCSMYSRLTERSMAIARVEPQIAEQGVPLQVRGSLDCAAIAHSLPFDDPEKKKRTAKG", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more GCST_C, GCV_T_N that are essential for its biological function; 2. The protein should belong to GcvT/YgfZ/DmdA that shares evolutionary origin and functional similarity; 3. The protein should be classified within GcvT/YgfZ_C, TrmE/GcvT_dom1 sharing conserved structural features. The designed protein sequence is ", "reference": "MANSWRISALRERHLALGSQLEDWNGMGTAWTYASDLADHHEAIRTRAGLMDVSGLKKVHYVGPHAESLLDYATTRDIGKLYPGKSVYACLLDEDGKFIDDCIVYRTGPNAFMVVHGAGTGHEMLIRSAQGRQVAVLFDDDLHDLSLQGPRAVDFLAEHVPGIRDLPYFHHLQTKLFDRPVMISRTGYTGERGYEIFCKAADAPAIWDAILEQGKGYGIIPCAFTALDWLRVESYLLFFPYDNSQMYPFADQKAGDTLWELGLDFTVSPGKQDFRGAGEHYRLKGQERFKIFGVLLDGHQAAQGGDTLWHDGRQVGVITCSMYSRLTERSMAIARVEPQIAEQGVPLQVRGSLDCAAIAHSLPFDDPEKKKRTAKG" }, { "InterPro": [ { "InterPro-ID": "IPR000792", "InterPro-Name": "Tscrpt_reg_LuxR_C", "InterPro-Type": "DOMAIN", "Beg": 192, "End": 208 }, { "InterPro-ID": "IPR000792", "InterPro-Name": "Tscrpt_reg_LuxR_C", "InterPro-Type": "DOMAIN", "Beg": 208, "End": 220 }, { "InterPro-ID": "IPR000792", "InterPro-Name": "Tscrpt_reg_LuxR_C", "InterPro-Type": "DOMAIN", "Beg": 178, "End": 192 }, { "InterPro-ID": "IPR000792", "InterPro-Name": "Tscrpt_reg_LuxR_C", "InterPro-Type": "DOMAIN", "Beg": 175, "End": 232 }, { "InterPro-ID": "IPR016032", "InterPro-Name": "Sig_transdc_resp-reg_C-effctor", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 173, "End": 234 }, { "InterPro-ID": "IPR000792", "InterPro-Name": "Tscrpt_reg_LuxR_C", "InterPro-Type": "DOMAIN", "Beg": 171, "End": 236 }, { "InterPro-ID": "IPR000792", "InterPro-Name": "Tscrpt_reg_LuxR_C", "InterPro-Type": "DOMAIN", "Beg": 192, "End": 219 }, { "InterPro-ID": "IPR000792", "InterPro-Name": "Tscrpt_reg_LuxR_C", "InterPro-Type": "DOMAIN", "Beg": 177, "End": 229 }, { "InterPro-ID": "IPR000792", "InterPro-Name": "Tscrpt_reg_LuxR_C", "InterPro-Type": "DOMAIN", "Beg": 178, "End": 231 } ], "response#1": "MHGAAVTPPSTVSPTPVPTQSAPLSVALVSHRCPDPCEVTGFHSRRVHEPCEIRPSDDVVLFYGPRMGQELRRFSTEANGGLPPFAVLATCLDWDDVCLALDSGAIGYLLEIEDPDLLAAALHCISHGHTILAPQIAEHARVTSCPGGALRQTAAVARPDTSGSATGRTGDSSPSLALSPQEREIMTRLASGLSVREIAVEMRLAEKTVRNYLSHIYGKLGVRSRSQALLRWLGHPGGETAHH", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Tscrpt_reg_LuxR_C, Tscrpt_reg_LuxR_C, Tscrpt_reg_LuxR_C, Tscrpt_reg_LuxR_C, Tscrpt_reg_LuxR_C, Tscrpt_reg_LuxR_C, Tscrpt_reg_LuxR_C, Tscrpt_reg_LuxR_C that are essential for its biological function; 2. The protein should be classified within Sig_transdc_resp-reg_C-effctor sharing conserved structural features. The designed protein sequence is ", "reference": "MHGAAVTPPSTVSPTPVPTQSAPLSVALVSHRCPDPCEVTGFHSRRVHEPCEIRPSDDVVLFYGPRMGQELRRFSTEANGGLPPFAVLATCLDWDDVCLALDSGAIGYLLEIEDPDLLAAALHCISHGHTILAPQIAEHARVTSCPGGALRQTAAVARPDTSGSATGRTGDSSPSLALSPQEREIMTRLASGLSVREIAVEMRLAEKTVRNYLSHIYGKLGVRSRSQALLRWLGHPGGETAHH" }, { "InterPro": [ { "InterPro-ID": "IPR007023", "InterPro-Name": "Ribosom_reg", "InterPro-Type": "FAMILY", "Beg": 20, "End": 191 } ], "response#1": "MSTDTSKPARLPVTVEKPTPYTFDLGLLLANDPNPVNVPKTTDTQVLEQHLASVARDGAQVLINQLLTTTTITATKDGVLLTLPPPTTPLPREKPVPQPKPETKWQAFARRRGIKPKTREQRRNLQYNPTTGQWERKWGYKGANKRGETDPIIEVSAAKEAMRPEGTSVRGDKRREIRARVKKNQKQMLRNQRIAAEKMGKK", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Ribosom_reg that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MSTDTSKPARLPVTVEKPTPYTFDLGLLLANDPNPVNVPKTTDTQVLEQHLASVARDGAQVLINQLLTTTTITATKDGVLLTLPPPTTPLPREKPVPQPKPETKWQAFARRRGIKPKTREQRRNLQYNPTTGQWERKWGYKGANKRGETDPIIEVSAAKEAMRPEGTSVRGDKRREIRARVKKNQKQMLRNQRIAAEKMGKK" }, { "InterPro": [ { "InterPro-ID": "IPR012816", "InterPro-Name": "NADAR", "InterPro-Type": "DOMAIN", "Beg": 15, "End": 180 }, { "InterPro-ID": "IPR012816", "InterPro-Name": "NADAR", "InterPro-Type": "DOMAIN", "Beg": 16, "End": 183 }, { "InterPro-ID": "IPR037238", "InterPro-Name": "YbiA-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 4, "End": 194 }, { "InterPro-ID": "IPR012816", "InterPro-Name": "NADAR", "InterPro-Type": "DOMAIN", "Beg": 19, "End": 183 }, { "InterPro-ID": "IPR037238", "InterPro-Name": "YbiA-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 15, "End": 184 } ], "response#1": "MHTKVYVSEDRTKVFVLFYEAACVFSNFYPSGFEAKPVENFLKDTEKKEKLLKFTCSEQYFMYNKALLVGDMDIAEQILKETNPMKMKLLGRKLSMTKEQLKLWSQKSKDVMYRACLEKFSQNEDCRMILFRTHGMKLVEASPTDKIWGIGLDKADQRCEDERNWRGSNWLGEVLDQVREELWTRQEFKSNREQILKESLETRCQILEHFSH", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more NADAR, NADAR, NADAR that are essential for its biological function; 2. The protein should be classified within YbiA-like_sf, YbiA-like_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MHTKVYVSEDRTKVFVLFYEAACVFSNFYPSGFEAKPVENFLKDTEKKEKLLKFTCSEQYFMYNKALLVGDMDIAEQILKETNPMKMKLLGRKLSMTKEQLKLWSQKSKDVMYRACLEKFSQNEDCRMILFRTHGMKLVEASPTDKIWGIGLDKADQRCEDERNWRGSNWLGEVLDQVREELWTRQEFKSNREQILKESLETRCQILEHFSH" }, { "InterPro": [ { "InterPro-ID": "IPR011008", "InterPro-Name": "Dimeric_a/b-barrel", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 84, "End": 165 }, { "InterPro-ID": "IPR011991", "InterPro-Name": "ArsR-like_HTH", "InterPro-Type": "DOMAIN", "Beg": 25, "End": 71 }, { "InterPro-ID": "IPR000485", "InterPro-Name": "AsnC-type_HTH_dom", "InterPro-Type": "DOMAIN", "Beg": 24, "End": 40 }, { "InterPro-ID": "IPR000485", "InterPro-Name": "AsnC-type_HTH_dom", "InterPro-Type": "DOMAIN", "Beg": 51, "End": 70 }, { "InterPro-ID": "IPR000485", "InterPro-Name": "AsnC-type_HTH_dom", "InterPro-Type": "DOMAIN", "Beg": 40, "End": 51 }, { "InterPro-ID": "IPR000485", "InterPro-Name": "AsnC-type_HTH_dom", "InterPro-Type": "DOMAIN", "Beg": 24, "End": 85 }, { "InterPro-ID": "IPR036390", "InterPro-Name": "WH_DNA-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 24, "End": 83 }, { "InterPro-ID": "IPR036388", "InterPro-Name": "WH-like_DNA-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 22, "End": 74 }, { "InterPro-ID": "IPR019888", "InterPro-Name": "Tscrpt_reg_AsnC-like", "InterPro-Type": "FAMILY", "Beg": 24, "End": 133 }, { "InterPro-ID": "IPR019887", "InterPro-Name": "Tscrpt_reg_AsnC/Lrp_C", "InterPro-Type": "DOMAIN", "Beg": 91, "End": 163 } ], "response#1": "MSEGSSITGVQTPGSPKDVRARDLDDIDRRILLALHDDARIPNSALAEMVGIAPSTCHGRVRRLQEIGVIRGFYTDIDPAAVGLGLQAMISVSLQSNARGKIRSFIAHIRTRPQVMDVYFLAGGDDFILHVAARDTEDLRKFVVENLNADSDVAGTQTSLIFEHLRGASPL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more ArsR-like_HTH, AsnC-type_HTH_dom, AsnC-type_HTH_dom, AsnC-type_HTH_dom, AsnC-type_HTH_dom, Tscrpt_reg_AsnC/Lrp_C that are essential for its biological function; 2. The protein should belong to Tscrpt_reg_AsnC-like that shares evolutionary origin and functional similarity; 3. The protein should be classified within Dimeric_a/b-barrel, WH_DNA-bd_sf, WH-like_DNA-bd_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MSEGSSITGVQTPGSPKDVRARDLDDIDRRILLALHDDARIPNSALAEMVGIAPSTCHGRVRRLQEIGVIRGFYTDIDPAAVGLGLQAMISVSLQSNARGKIRSFIAHIRTRPQVMDVYFLAGGDDFILHVAARDTEDLRKFVVENLNADSDVAGTQTSLIFEHLRGASPL" }, { "InterPro": [ { "InterPro-ID": "IPR001041", "InterPro-Name": "2Fe-2S_ferredoxin-type", "InterPro-Type": "DOMAIN", "Beg": 227, "End": 299 }, { "InterPro-ID": "IPR001041", "InterPro-Name": "2Fe-2S_ferredoxin-type", "InterPro-Type": "DOMAIN", "Beg": 226, "End": 309 }, { "InterPro-ID": "IPR036010", "InterPro-Name": "2Fe-2S_ferredoxin-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 207, "End": 302 }, { "InterPro-ID": "IPR054582", "InterPro-Name": "DmmA-like_N", "InterPro-Type": "DOMAIN", "Beg": 98, "End": 211 }, { "InterPro-ID": "IPR017927", "InterPro-Name": "FAD-bd_FR_type", "InterPro-Type": "DOMAIN", "Beg": 2, "End": 103 }, { "InterPro-ID": "IPR001041", "InterPro-Name": "2Fe-2S_ferredoxin-type", "InterPro-Type": "DOMAIN", "Beg": 229, "End": 298 }, { "InterPro-ID": "IPR017938", "InterPro-Name": "Riboflavin_synthase-like_b-brl", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 3, "End": 98 }, { "InterPro-ID": "IPR012675", "InterPro-Name": "Beta-grasp_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 217, "End": 309 }, { "InterPro-ID": "IPR050415", "InterPro-Name": "MRET", "InterPro-Type": "FAMILY", "Beg": 6, "End": 263 }, { "InterPro-ID": "IPR039261", "InterPro-Name": "FNR_nucleotide-bd", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 96, "End": 226 }, { "InterPro-ID": "IPR006058", "InterPro-Name": "2Fe2S_fd_BS", "InterPro-Type": "BINDING_SITE", "Beg": 260, "End": 268 }, { "InterPro-ID": "IPR039261", "InterPro-Name": "FNR_nucleotide-bd", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 100, "End": 216 } ], "response#1": "MSTLLDVRVAAIRELTPVIREYSFEALASTLPGFSAGSHVQLHLPNGRRNAYSLLSDPADTRQYRIAVRQQDASRGGSRYLHQHLKVGDRLRLSPPANLFPLHGEAQKHILVAAGIGITPFLAYSQELLRRGADFELHYAYRAGSSDAYVDELRQQLGPRLHEYLSGQRRLDLASLLQGRTLGTHVYACGPQSLLLDLQEQASAQGWSPRRVHWEAFAAAEPGQPFRVELARSGQQLEVAADESLLEALEAAGVEVPNLCRGGVCGQCQTPWLKGDVEHRDHFLSANERTSSLMPCVSRGCGSPILLDL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more 2Fe-2S_ferredoxin-type, 2Fe-2S_ferredoxin-type, DmmA-like_N, FAD-bd_FR_type, 2Fe-2S_ferredoxin-type that are essential for its biological function; 2. The protein should belong to MRET that shares evolutionary origin and functional similarity; 3. The protein should be classified within 2Fe-2S_ferredoxin-like_sf, Riboflavin_synthase-like_b-brl, Beta-grasp_dom_sf, FNR_nucleotide-bd, FNR_nucleotide-bd sharing conserved structural features; 4. The protein should include a 2Fe2S_fd_BS that enables ligand binding under diverse conditions. The designed protein sequence is ", "reference": "MSTLLDVRVAAIRELTPVIREYSFEALASTLPGFSAGSHVQLHLPNGRRNAYSLLSDPADTRQYRIAVRQQDASRGGSRYLHQHLKVGDRLRLSPPANLFPLHGEAQKHILVAAGIGITPFLAYSQELLRRGADFELHYAYRAGSSDAYVDELRQQLGPRLHEYLSGQRRLDLASLLQGRTLGTHVYACGPQSLLLDLQEQASAQGWSPRRVHWEAFAAAEPGQPFRVELARSGQQLEVAADESLLEALEAAGVEVPNLCRGGVCGQCQTPWLKGDVEHRDHFLSANERTSSLMPCVSRGCGSPILLDL" }, { "InterPro": [ { "InterPro-ID": "IPR011989", "InterPro-Name": "ARM-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1, "End": 328 }, { "InterPro-ID": "IPR047038", "InterPro-Name": "eEF3_chromodomain-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 762, "End": 871 }, { "InterPro-ID": "IPR050611", "InterPro-Name": "ABCF_EF3_subfamily", "InterPro-Type": "FAMILY", "Beg": 644, "End": 973 }, { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 436, "End": 618 }, { "InterPro-ID": "IPR040533", "InterPro-Name": "EF3_4HB", "InterPro-Type": "DOMAIN", "Beg": 336, "End": 411 }, { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 420, "End": 636 }, { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 669, "End": 975 }, { "InterPro-ID": "IPR034085", "InterPro-Name": "TOG", "InterPro-Type": "DOMAIN", "Beg": 3, "End": 226 }, { "InterPro-ID": "IPR003593", "InterPro-Name": "AAA+_ATPase", "InterPro-Type": "DOMAIN", "Beg": 693, "End": 970 }, { "InterPro-ID": "IPR003593", "InterPro-Name": "AAA+_ATPase", "InterPro-Type": "DOMAIN", "Beg": 455, "End": 617 }, { "InterPro-ID": "IPR003439", "InterPro-Name": "ABC_transporter-like_ATP-bd", "InterPro-Type": "DOMAIN", "Beg": 667, "End": 993 }, { "InterPro-ID": "IPR017871", "InterPro-Name": "ABC_transporter-like_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 897, "End": 911 }, { "InterPro-ID": "IPR047036", "InterPro-Name": "EF3_4HB_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 329, "End": 418 }, { "InterPro-ID": "IPR003439", "InterPro-Name": "ABC_transporter-like_ATP-bd", "InterPro-Type": "DOMAIN", "Beg": 685, "End": 780 }, { "InterPro-ID": "IPR021133", "InterPro-Name": "HEAT_type_2", "InterPro-Type": "REPEAT", "Beg": 171, "End": 209 }, { "InterPro-ID": "IPR015688", "InterPro-Name": "eEF3_ABC2_chromodomain-like", "InterPro-Type": "DOMAIN", "Beg": 794, "End": 861 }, { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 643, "End": 969 }, { "InterPro-ID": "IPR003439", "InterPro-Name": "ABC_transporter-like_ATP-bd", "InterPro-Type": "DOMAIN", "Beg": 446, "End": 572 }, { "InterPro-ID": "IPR017871", "InterPro-Name": "ABC_transporter-like_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 544, "End": 558 }, { "InterPro-ID": "IPR003439", "InterPro-Name": "ABC_transporter-like_ATP-bd", "InterPro-Type": "DOMAIN", "Beg": 426, "End": 641 }, { "InterPro-ID": "IPR003439", "InterPro-Name": "ABC_transporter-like_ATP-bd", "InterPro-Type": "DOMAIN", "Beg": 872, "End": 925 }, { "InterPro-ID": "IPR016024", "InterPro-Name": "ARM-type_fold", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 48, "End": 1036 } ], "response#1": "MSDSQQSVEVLNQLLARLSVATPDNRDEVATEVSSFVNGNIIEHDAPEHFFNGLAKAIKDKKSAVNALAAVSHVASTSGLAPSVEPYVVALVPAILEQTGSKDKDVQSAANAALHAVVTAVNPVAVKAVLPHLTKSLSETNKWQEKVAVLSAISALVDQAKSQISLRMTELIPVLSEAMWDTKKEVKNAATATMTKATETVENKDIERFIPKLIECIANPSEVPETVHLLGATTFVAEVTPATLSIMTPLLSRGLAERETPIKRKSAVIIDNMCKLVEDPQIVAPFLNKLLPGLKNNFSVIADPEAREVTLRGLKTLRRVGAVGEGDVLPEISHAGDPATTLGVLDSLLKTENIAKKFRPAVEYISCIGGDLIDERIIDQQTWFTHVLPYMTIFLHQNQAKEILDEFRKRAVDNIPEPPKFDDEEEEGEDLCNCEFSLAYGAKILLNRTQLRLKRGRRYGLCGPNGSGKSTLMRAIANGQVDGFPSQEECRTVYVEHDIDGTHAETSVLDFVFQGDVGTKEAISAKLKEFGFDDEMIVMPIAALSGGWKMKLALARAVLKNADILLLDEPTNHLDTVNVAWLTNYLITCGITSIVVSHDSGFLDNICQYIIHYEGLKLRKYKGNLSALVERVPSAKSYYELGASDLEFRFPEPGYLEGVKTKQKAIVKVSNMTFQYPGTSKPQISDVSFQCSLSSRIAVIGPNGAGKSTLINVLTGELLPTTGEVYTHENIRIAYIKQHAFAHIESHLDKTPSEYIQWRFQTGEDRETMDRANRQINEDDAQAMNKIFKIDGTPRRIAGIHSRRKFKNSYEYECSFLLGENIGMKSERWVPMMSVDNAWLPRGEVIESHGKMVAEVDMKEALASGQFRPLTRKEIEEHCAMLGLDAELVSHSRIRGLSGGQKVKLVLAAGTWQRPHLIVLDEPTNYLDRDSLGALSKALKEFEGGVIIITHSAEFTKDLTEEVWAVRDGLMTPSGHNWVSGQGSGPRLEKKEDEEDKFDAMGNKISSGTKKTKLSSAELRKKKKERMKKKKELGDAYVSDDDADF", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more EF3_4HB, TOG, AAA+_ATPase, AAA+_ATPase, ABC_transporter-like_ATP-bd, ABC_transporter-like_ATP-bd, eEF3_ABC2_chromodomain-like, ABC_transporter-like_ATP-bd, ABC_transporter-like_ATP-bd, ABC_transporter-like_ATP-bd that are essential for its biological function; 2. The protein should belong to ABCF_EF3_subfamily that shares evolutionary origin and functional similarity; 3. The protein should be classified within ARM-like, eEF3_chromodomain-like_sf, P-loop_NTPase, P-loop_NTPase, P-loop_NTPase, EF3_4HB_sf, P-loop_NTPase, ARM-type_fold sharing conserved structural features; 4. The protein should include one or more HEAT_type_2 that provide structural or functional support; 5. The protein should contain ABC_transporter-like_CS, ABC_transporter-like_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MSDSQQSVEVLNQLLARLSVATPDNRDEVATEVSSFVNGNIIEHDAPEHFFNGLAKAIKDKKSAVNALAAVSHVASTSGLAPSVEPYVVALVPAILEQTGSKDKDVQSAANAALHAVVTAVNPVAVKAVLPHLTKSLSETNKWQEKVAVLSAISALVDQAKSQISLRMTELIPVLSEAMWDTKKEVKNAATATMTKATETVENKDIERFIPKLIECIANPSEVPETVHLLGATTFVAEVTPATLSIMTPLLSRGLAERETPIKRKSAVIIDNMCKLVEDPQIVAPFLNKLLPGLKNNFSVIADPEAREVTLRGLKTLRRVGAVGEGDVLPEISHAGDPATTLGVLDSLLKTENIAKKFRPAVEYISCIGGDLIDERIIDQQTWFTHVLPYMTIFLHQNQAKEILDEFRKRAVDNIPEPPKFDDEEEEGEDLCNCEFSLAYGAKILLNRTQLRLKRGRRYGLCGPNGSGKSTLMRAIANGQVDGFPSQEECRTVYVEHDIDGTHAETSVLDFVFQGDVGTKEAISAKLKEFGFDDEMIVMPIAALSGGWKMKLALARAVLKNADILLLDEPTNHLDTVNVAWLTNYLITCGITSIVVSHDSGFLDNICQYIIHYEGLKLRKYKGNLSALVERVPSAKSYYELGASDLEFRFPEPGYLEGVKTKQKAIVKVSNMTFQYPGTSKPQISDVSFQCSLSSRIAVIGPNGAGKSTLINVLTGELLPTTGEVYTHENIRIAYIKQHAFAHIESHLDKTPSEYIQWRFQTGEDRETMDRANRQINEDDAQAMNKIFKIDGTPRRIAGIHSRRKFKNSYEYECSFLLGENIGMKSERWVPMMSVDNAWLPRGEVIESHGKMVAEVDMKEALASGQFRPLTRKEIEEHCAMLGLDAELVSHSRIRGLSGGQKVKLVLAAGTWQRPHLIVLDEPTNYLDRDSLGALSKALKEFEGGVIIITHSAEFTKDLTEEVWAVRDGLMTPSGHNWVSGQGSGPRLEKKEDEEDKFDAMGNKISSGTKKTKLSSAELRKKKKERMKKKKELGDAYVSDDDADF" }, { "InterPro": [ { "InterPro-ID": "IPR024338", "InterPro-Name": "MID1/Yam8", "InterPro-Type": "FAMILY", "Beg": 4, "End": 622 }, { "InterPro-ID": "IPR024338", "InterPro-Name": "MID1/Yam8", "InterPro-Type": "FAMILY", "Beg": 226, "End": 598 } ], "response#1": "MPAREVYLKRPATRRQLEGICTRYDGQQRITQLDCEEGCSKRTQPPQRLNPRYKSPDLIHISFIIVLLCILSMTSSVVAQTTTGSSSSKAAATPILPRQTLPTTISLPPLNISHPVLQLALPPTSSLYLTFSICSLTSNATILPTVLISTSSPASFNLGSKPIRDASTGGIPTSSGGKGYNYKSGRNGATWGLKWSSGFGNWTLNGTSETQVHLLLGLGLGNDGSTLNTTGVGNGNVVVQMGASTSGPLHALSAVYPLLGDTTSTSALIFSPLLYSSPQPEPSYPNYTLPGAQLAFPDFSYSEPLNSSLSSNLTLIVVPTNASPTSTDLGNSICAINAASANSSVSGANNTILKSFQPEWMTVGDEQGFRSYWVLGDLAEQGNYTAWVSDDKGVLSQPAWFATKPAGFPCQLVMPNDVCPNLGYSAPLDANSTAVTSPSGATISPTSPIQTLPDDLLELIVQNLEAFSTSLLSHACGRDLFSHVSSCLDCYSAYRDWLCRIVVPQCGAANSTSGATVIETATSTSTSSGTFPTPSTVLRTPSSPRNPSLPIPAYSYYELLPCMSTCNRADRSCPVSMGIRCPKRKVNAAKSYAFVGDDHSYGDGSAAQGVAAQDRWGNRWCNG", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to MID1/Yam8, MID1/Yam8 that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MPAREVYLKRPATRRQLEGICTRYDGQQRITQLDCEEGCSKRTQPPQRLNPRYKSPDLIHISFIIVLLCILSMTSSVVAQTTTGSSSSKAAATPILPRQTLPTTISLPPLNISHPVLQLALPPTSSLYLTFSICSLTSNATILPTVLISTSSPASFNLGSKPIRDASTGGIPTSSGGKGYNYKSGRNGATWGLKWSSGFGNWTLNGTSETQVHLLLGLGLGNDGSTLNTTGVGNGNVVVQMGASTSGPLHALSAVYPLLGDTTSTSALIFSPLLYSSPQPEPSYPNYTLPGAQLAFPDFSYSEPLNSSLSSNLTLIVVPTNASPTSTDLGNSICAINAASANSSVSGANNTILKSFQPEWMTVGDEQGFRSYWVLGDLAEQGNYTAWVSDDKGVLSQPAWFATKPAGFPCQLVMPNDVCPNLGYSAPLDANSTAVTSPSGATISPTSPIQTLPDDLLELIVQNLEAFSTSLLSHACGRDLFSHVSSCLDCYSAYRDWLCRIVVPQCGAANSTSGATVIETATSTSTSSGTFPTPSTVLRTPSSPRNPSLPIPAYSYYELLPCMSTCNRADRSCPVSMGIRCPKRKVNAAKSYAFVGDDHSYGDGSAAQGVAAQDRWGNRWCNG" }, { "InterPro": [ { "InterPro-ID": "IPR007523", "InterPro-Name": "NDUFAF3/AAMDC", "InterPro-Type": "FAMILY", "Beg": 59, "End": 170 }, { "InterPro-ID": "IPR036748", "InterPro-Name": "MTH938-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 56, "End": 173 }, { "InterPro-ID": "IPR007523", "InterPro-Name": "NDUFAF3/AAMDC", "InterPro-Type": "FAMILY", "Beg": 34, "End": 174 }, { "InterPro-ID": "IPR034095", "InterPro-Name": "NDUF3", "InterPro-Type": "FAMILY", "Beg": 57, "End": 172 }, { "InterPro-ID": "IPR036748", "InterPro-Name": "MTH938-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 56, "End": 172 } ], "response#1": "MIARTLRTVGRQGRNLLLPRITACRPLHAIPANFSKAYDHDGKTKVTIFNTETDLGLMVTGYSQYGFRLNNDMVLIGPISVFPRSVLSWNVNSFEDINEDSLSLFPTLEPKIDVLIIGIGDQAPPPALSKRIIEFMKKYKINVEILRTEQACATFNFLNAENRMVACALIPPLHLSYNENDILQAKLRKKELYETE", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to NDUFAF3/AAMDC, NDUFAF3/AAMDC, NDUF3 that shares evolutionary origin and functional similarity; 2. The protein should be classified within MTH938-like_sf, MTH938-like_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MIARTLRTVGRQGRNLLLPRITACRPLHAIPANFSKAYDHDGKTKVTIFNTETDLGLMVTGYSQYGFRLNNDMVLIGPISVFPRSVLSWNVNSFEDINEDSLSLFPTLEPKIDVLIIGIGDQAPPPALSKRIIEFMKKYKINVEILRTEQACATFNFLNAENRMVACALIPPLHLSYNENDILQAKLRKKELYETE" }, { "InterPro": [ { "InterPro-ID": "IPR032063", "InterPro-Name": "MavL-like", "InterPro-Type": "FAMILY", "Beg": 48, "End": 496 } ], "response#1": "MSTFGAEVDQVWPAVTGDSPHLTNFGRKLLKDCRQVQKPIGGYENLGNVIKLSAEFPLEFGVNSVKVYRQSPSRLARINEEVASAYPLIHERTLGLYLQYLEHKCRWGNAVEKPIYRNLSLCGFVQRLLVKRCASFFARNDKYLLVSGESGASGFEAVGTREEKAPLVLANVLSYDDIKLSALLSVSSRTEFVNEGERTNCGHVDLNTKTLERHGVIVGMIGARLSRRNLMEFQDIVIARQQNTRERGYGMALDEPATTRDEDYRRLWREFYATRDLIHGQAVIDNQRFGPSKNKMDVFDNLVMKRRYAISFDMLLLEAEARAKRVKKLAYIHVVGFGLGVWKAAEQQERIFMETFEQRMRTLGNRLNNVGLVHFSWFSITHCGGLSNGSLIEIPGHPKDGIRVLISKRNPARKLSDPEHAGMLLVVSYAWDGNALPGNEFWMKMLQSTGDSSTACSTLVAELHNPYINTKFCNGGNLHIASPEHGVLHIAEYAKRVIRSESDAL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to MavL-like that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MSTFGAEVDQVWPAVTGDSPHLTNFGRKLLKDCRQVQKPIGGYENLGNVIKLSAEFPLEFGVNSVKVYRQSPSRLARINEEVASAYPLIHERTLGLYLQYLEHKCRWGNAVEKPIYRNLSLCGFVQRLLVKRCASFFARNDKYLLVSGESGASGFEAVGTREEKAPLVLANVLSYDDIKLSALLSVSSRTEFVNEGERTNCGHVDLNTKTLERHGVIVGMIGARLSRRNLMEFQDIVIARQQNTRERGYGMALDEPATTRDEDYRRLWREFYATRDLIHGQAVIDNQRFGPSKNKMDVFDNLVMKRRYAISFDMLLLEAEARAKRVKKLAYIHVVGFGLGVWKAAEQQERIFMETFEQRMRTLGNRLNNVGLVHFSWFSITHCGGLSNGSLIEIPGHPKDGIRVLISKRNPARKLSDPEHAGMLLVVSYAWDGNALPGNEFWMKMLQSTGDSSTACSTLVAELHNPYINTKFCNGGNLHIASPEHGVLHIAEYAKRVIRSESDAL" }, { "InterPro": [ { "InterPro-ID": "IPR032063", "InterPro-Name": "MavL-like", "InterPro-Type": "FAMILY", "Beg": 59, "End": 505 } ], "response#1": "MRSFLYMLSQRPKLACLCGKSIIIWPGKRTNLPENAFTQRMLQECGQMAKPDASVDLDNFKAISEQSPAEFGIDSCRVKAQPEDRSDRIREQIASAYPVIHERTLLLFISFLEHKLTFGSEQEKAIYKDMTVVDLVQRLLAKRCVWFFGANDYYRTMQGNIGNEGFEAVGTPAEKEPLTLTSVLSYDEIKLSALLYVSCHSEFINNGSRVNGGEVLQNKDTIEREGVVIGLIGARFERPDVMEYQDIMITKTQNTEANGYGFDLEQISSETVTPASDLRRIWREFYEEPRDFIYADTPYDTTRFEEVSQGIFDHQVMRKRYAISFDTLLLEAQDRAFKAGKPAYIHVVGIGLGVWKAARQQERTFLESFEGRLRALGERLSHIGVVHFSWFHLACVGSLHDGAIIPVDKHPQGGIRIRNSVRNPGDKLTEDMLPVVTYAWDGNALPGNEFWANMLISTGDPAAACSTLISELQNPHINVHYMNGANLHIASVEHGLLHVGDYARRLIV", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to MavL-like that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MRSFLYMLSQRPKLACLCGKSIIIWPGKRTNLPENAFTQRMLQECGQMAKPDASVDLDNFKAISEQSPAEFGIDSCRVKAQPEDRSDRIREQIASAYPVIHERTLLLFISFLEHKLTFGSEQEKAIYKDMTVVDLVQRLLAKRCVWFFGANDYYRTMQGNIGNEGFEAVGTPAEKEPLTLTSVLSYDEIKLSALLYVSCHSEFINNGSRVNGGEVLQNKDTIEREGVVIGLIGARFERPDVMEYQDIMITKTQNTEANGYGFDLEQISSETVTPASDLRRIWREFYEEPRDFIYADTPYDTTRFEEVSQGIFDHQVMRKRYAISFDTLLLEAQDRAFKAGKPAYIHVVGIGLGVWKAARQQERTFLESFEGRLRALGERLSHIGVVHFSWFHLACVGSLHDGAIIPVDKHPQGGIRIRNSVRNPGDKLTEDMLPVVTYAWDGNALPGNEFWANMLISTGDPAAACSTLISELQNPHINVHYMNGANLHIASVEHGLLHVGDYARRLIV" }, { "InterPro": [ { "InterPro-ID": "IPR000182", "InterPro-Name": "GNAT_dom", "InterPro-Type": "DOMAIN", "Beg": 33, "End": 143 }, { "InterPro-ID": "IPR016181", "InterPro-Name": "Acyl_CoA_acyltransferase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 19, "End": 150 }, { "InterPro-ID": "IPR000182", "InterPro-Name": "GNAT_dom", "InterPro-Type": "DOMAIN", "Beg": 1, "End": 162 } ], "response#1": "MSGYSAPRRISDADDVTSFSSGEPSLDDYLRKRALANHVQGGSRCFVTCRDGRVVGFYALASGSVAHADAPGRVRRNMPDPVPVILLSRLAVDRKEQGRGLGSHLLRDAIGRCVQAADSIGLRAILVHALHDEARAFYVHFDFEISPTDPLHLMLLMKDARALIGD", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more GNAT_dom, GNAT_dom that are essential for its biological function; 2. The protein should be classified within Acyl_CoA_acyltransferase sharing conserved structural features. The designed protein sequence is ", "reference": "MSGYSAPRRISDADDVTSFSSGEPSLDDYLRKRALANHVQGGSRCFVTCRDGRVVGFYALASGSVAHADAPGRVRRNMPDPVPVILLSRLAVDRKEQGRGLGSHLLRDAIGRCVQAADSIGLRAILVHALHDEARAFYVHFDFEISPTDPLHLMLLMKDARALIGD" }, { "InterPro": [ { "InterPro-ID": "IPR010982", "InterPro-Name": "Lambda_DNA-bd_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1, "End": 110 }, { "InterPro-ID": "IPR015060", "InterPro-Name": "Aca2_YdiL-like", "InterPro-Type": "FAMILY", "Beg": 1, "End": 112 }, { "InterPro-ID": "IPR027910", "InterPro-Name": "YdiL_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1, "End": 116 } ], "response#1": "MTNKELQAIRKLLMLDVSEAAEHIGRVSARSWQYWESGRSAVPDDVEQEMLDLASVRIEMMSAIDKRLADGERPKLRFYNKLDEYLADNPDHNVIGWRLSQSVAALYYTEGHADLI", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Aca2_YdiL-like that shares evolutionary origin and functional similarity; 2. The protein should be classified within Lambda_DNA-bd_dom_sf, YdiL_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MTNKELQAIRKLLMLDVSEAAEHIGRVSARSWQYWESGRSAVPDDVEQEMLDLASVRIEMMSAIDKRLADGERPKLRFYNKLDEYLADNPDHNVIGWRLSQSVAALYYTEGHADLI" }, { "InterPro": [ { "InterPro-ID": "IPR002061", "InterPro-Name": "Scorpion_toxinL/defensin", "InterPro-Type": "FAMILY", "Beg": 9, "End": 54 }, { "InterPro-ID": "IPR044062", "InterPro-Name": "LCN-type_CS_alpha_beta_dom", "InterPro-Type": "DOMAIN", "Beg": 7, "End": 69 }, { "InterPro-ID": "IPR003614", "InterPro-Name": "Scorpion_toxin-like", "InterPro-Type": "DOMAIN", "Beg": 6, "End": 56 }, { "InterPro-ID": "IPR036574", "InterPro-Name": "Scorpion_toxin-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 8, "End": 69 }, { "InterPro-ID": "IPR018218", "InterPro-Name": "Scorpion_toxinL", "InterPro-Type": "FAMILY", "Beg": 17, "End": 24 }, { "InterPro-ID": "IPR018218", "InterPro-Name": "Scorpion_toxinL", "InterPro-Type": "FAMILY", "Beg": 49, "End": 62 }, { "InterPro-ID": "IPR018218", "InterPro-Name": "Scorpion_toxinL", "InterPro-Type": "FAMILY", "Beg": 26, "End": 33 }, { "InterPro-ID": "IPR018218", "InterPro-Name": "Scorpion_toxinL", "InterPro-Type": "FAMILY", "Beg": 37, "End": 47 } ], "response#1": "LIGVKTEHGYLLDKYTGCKVWCVINNESCNGECKRRGGYYGYCYFWKLACFCQGARKSELWHYETNKCNGRM", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more LCN-type_CS_alpha_beta_dom, Scorpion_toxin-like that are essential for its biological function; 2. The protein should belong to Scorpion_toxinL/defensin, Scorpion_toxinL, Scorpion_toxinL, Scorpion_toxinL, Scorpion_toxinL that shares evolutionary origin and functional similarity; 3. The protein should be classified within Scorpion_toxin-like_sf sharing conserved structural features. The designed protein sequence is ", "reference": "LIGVKTEHGYLLDKYTGCKVWCVINNESCNGECKRRGGYYGYCYFWKLACFCQGARKSELWHYETNKCNGRM" }, { "InterPro": [ { "InterPro-ID": "IPR051795", "InterPro-Name": "Glycosyl_Hydrlase_43", "InterPro-Type": "FAMILY", "Beg": 3, "End": 529 }, { "InterPro-ID": "IPR006710", "InterPro-Name": "Glyco_hydro_43", "InterPro-Type": "FAMILY", "Beg": 5, "End": 294 }, { "InterPro-ID": "IPR041542", "InterPro-Name": "GH43_C2", "InterPro-Type": "DOMAIN", "Beg": 326, "End": 527 }, { "InterPro-ID": "IPR013320", "InterPro-Name": "ConA-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 321, "End": 528 }, { "InterPro-ID": "IPR023296", "InterPro-Name": "Glyco_hydro_beta-prop_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1, "End": 318 }, { "InterPro-ID": "IPR023296", "InterPro-Name": "Glyco_hydro_beta-prop_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 5, "End": 311 } ], "response#1": "MPQVRNPILPGFNPDPSILRVGEDYYIATSTFEWYPGVQIHHSRDLANWELVARPLNRKSQLDMRGNPDSCGIWAPCLSHDGERFWLVYTDVKRKDGSFKDTPNYIVTAEKIEGPWSDPIYINSSGFDPSLFHDDDGRKWFVNMLWDHRRRPQLFEGIVLQEFDPKAGKLVGPRKNIFTGTDLALVEGPHLYKRNGWYYLLTAEGGTGYEHACTFARSRNIWGPYEVHPQKYILTSKDHPHAALQRAGHGDIVDTPDGRTYLVHLTGRPTTQFRRCVLGRETAIQEAYWGDDDWLYVKNGPVPSLWVDLPAARDDTKYWEEKRYTFESGLHKDFQWLRTPETDRIFRTREDGKLTLIGRESIGSWFEQALVARRQTHFSCDAETVIDFSPEDQRQFAGLTAYYCRYNFFYLAVSAHSDGQRELFIMASEASWPLGELRYPVPEGVRIPNEGKVRLALTIRGRELQFYYALEGEELKKIGPVLDASIVSDECGGHQKHGSFTGAFVGVAASDLNGTAAEATFDYFIYRPVQHPSDRYEI", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more GH43_C2 that are essential for its biological function; 2. The protein should belong to Glycosyl_Hydrlase_43, Glyco_hydro_43 that shares evolutionary origin and functional similarity; 3. The protein should be classified within ConA-like_dom_sf, Glyco_hydro_beta-prop_sf, Glyco_hydro_beta-prop_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MPQVRNPILPGFNPDPSILRVGEDYYIATSTFEWYPGVQIHHSRDLANWELVARPLNRKSQLDMRGNPDSCGIWAPCLSHDGERFWLVYTDVKRKDGSFKDTPNYIVTAEKIEGPWSDPIYINSSGFDPSLFHDDDGRKWFVNMLWDHRRRPQLFEGIVLQEFDPKAGKLVGPRKNIFTGTDLALVEGPHLYKRNGWYYLLTAEGGTGYEHACTFARSRNIWGPYEVHPQKYILTSKDHPHAALQRAGHGDIVDTPDGRTYLVHLTGRPTTQFRRCVLGRETAIQEAYWGDDDWLYVKNGPVPSLWVDLPAARDDTKYWEEKRYTFESGLHKDFQWLRTPETDRIFRTREDGKLTLIGRESIGSWFEQALVARRQTHFSCDAETVIDFSPEDQRQFAGLTAYYCRYNFFYLAVSAHSDGQRELFIMASEASWPLGELRYPVPEGVRIPNEGKVRLALTIRGRELQFYYALEGEELKKIGPVLDASIVSDECGGHQKHGSFTGAFVGVAASDLNGTAAEATFDYFIYRPVQHPSDRYEI" }, { "InterPro": [ { "InterPro-ID": "IPR006614", "InterPro-Name": "Peroxin/Ferlin", "InterPro-Type": "DOMAIN", "Beg": 299, "End": 367 }, { "InterPro-ID": "IPR052646", "InterPro-Name": "Peroxisomal_PEX28-32", "InterPro-Type": "FAMILY", "Beg": 47, "End": 484 }, { "InterPro-ID": "IPR006614", "InterPro-Name": "Peroxin/Ferlin", "InterPro-Type": "DOMAIN", "Beg": 392, "End": 425 }, { "InterPro-ID": "IPR010482", "InterPro-Name": "TECPR1-like_DysF", "InterPro-Type": "DOMAIN", "Beg": 70, "End": 420 } ], "response#1": "MPTDPNSNPVSKAGLTPSSINSNISEVQPTTGLNTINAAAGVKVKETENLRANFTAKSSLPAGSEITCTPQSSPLLSSTPPTVSKSLIKAYPYLIALNKILGVLTWTDDTSYISVLLVTTATLFILYFENFVIYLGHLSIVGLIFLYSIFRSYVEKEQKKSPTLDDVVHCLTTVSVRADMLLFPVSSLNLTSADLRRLLFTSIFLSPGYILVCYLLFPPKTLLLILVIFFLTYHSSWSRVTRKLLWRSSIVRAFCFYNTGLIFESGNNEKSSLFKTAMNKTNKKLKEVTRKAGGKHSGPVRFTYVLYENQRRWLGVGWTPNLLSYERTPWTDEFLNEAESPDNFELPQLNDDSGMYWRWIDKTWRLDLTNDGALQLPSSKYKTTADPKPDEGFIYYDNTWKNPSTEDSFSKYTRRRRWIRTAELVSPGDDSSTDSASLPHSASETVGLTLPKSTSISDVQSVNASGNITTSAETAPDSAGTAKKRKSLRFDATSTVYEEGVSDLKNVKETLEGGATDKKEE", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Peroxin/Ferlin, Peroxin/Ferlin, TECPR1-like_DysF that are essential for its biological function; 2. The protein should belong to Peroxisomal_PEX28-32 that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MPTDPNSNPVSKAGLTPSSINSNISEVQPTTGLNTINAAAGVKVKETENLRANFTAKSSLPAGSEITCTPQSSPLLSSTPPTVSKSLIKAYPYLIALNKILGVLTWTDDTSYISVLLVTTATLFILYFENFVIYLGHLSIVGLIFLYSIFRSYVEKEQKKSPTLDDVVHCLTTVSVRADMLLFPVSSLNLTSADLRRLLFTSIFLSPGYILVCYLLFPPKTLLLILVIFFLTYHSSWSRVTRKLLWRSSIVRAFCFYNTGLIFESGNNEKSSLFKTAMNKTNKKLKEVTRKAGGKHSGPVRFTYVLYENQRRWLGVGWTPNLLSYERTPWTDEFLNEAESPDNFELPQLNDDSGMYWRWIDKTWRLDLTNDGALQLPSSKYKTTADPKPDEGFIYYDNTWKNPSTEDSFSKYTRRRRWIRTAELVSPGDDSSTDSASLPHSASETVGLTLPKSTSISDVQSVNASGNITTSAETAPDSAGTAKKRKSLRFDATSTVYEEGVSDLKNVKETLEGGATDKKEE" }, { "InterPro": [ { "InterPro-ID": "IPR052816", "InterPro-Name": "Peroxisomal_Membrane_PEX28-32", "InterPro-Type": "FAMILY", "Beg": 66, "End": 483 }, { "InterPro-ID": "IPR010482", "InterPro-Name": "TECPR1-like_DysF", "InterPro-Type": "DOMAIN", "Beg": 130, "End": 503 } ], "response#1": "MSNSPPSSSSSGKGLSIPRKLALNAINEIQNRSNDYLLSKRGGKGLEEGRKRAALAAVISTVSSVGADRLTKADFDELRDLSEQESHDKVHFMDKLTNKLLDAIPRRSDESMDELRKRLEDRHRVEQPGLSIKRISRNFKTLSSKMDLVFSLQYSIIHVISWDKPSLTLTFLILYTWGCLMPYLFLVYPVFYVLTGVLIPNYLYRHPLAKPDIIPTRARGDSSIFGFLRTENAWELDRQRILLERSRTLERILSQELELSTISSRTSTDSEDEGSSSLFYEVFTADSKSNLVFKAVLEEDEETTEKGRTGVVDKVKLLINMRDLQNLTSDIIKMMTRMQDSIYENYSFKDEKRSTKHFFNLIALILITIVLGPYIPWRAIFIITVWVLILLKHPNRQHILKQLKPATKHKLPPKHRTEVKRRASRLGELIVDDPPQYRTIQIYQIEKQDLIKPSVYELYMYSSSIFNESDTLRIQKKDPRGLPISHWCKLPAQAGNSRKRIGQWTPIRDPGASKTVSWMRWRLTESGHMTSPASIVVAVLCVRLSDTAGHQKSDRGSTMIPEPVRRKAV", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more TECPR1-like_DysF that are essential for its biological function; 2. The protein should belong to Peroxisomal_Membrane_PEX28-32 that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MSNSPPSSSSSGKGLSIPRKLALNAINEIQNRSNDYLLSKRGGKGLEEGRKRAALAAVISTVSSVGADRLTKADFDELRDLSEQESHDKVHFMDKLTNKLLDAIPRRSDESMDELRKRLEDRHRVEQPGLSIKRISRNFKTLSSKMDLVFSLQYSIIHVISWDKPSLTLTFLILYTWGCLMPYLFLVYPVFYVLTGVLIPNYLYRHPLAKPDIIPTRARGDSSIFGFLRTENAWELDRQRILLERSRTLERILSQELELSTISSRTSTDSEDEGSSSLFYEVFTADSKSNLVFKAVLEEDEETTEKGRTGVVDKVKLLINMRDLQNLTSDIIKMMTRMQDSIYENYSFKDEKRSTKHFFNLIALILITIVLGPYIPWRAIFIITVWVLILLKHPNRQHILKQLKPATKHKLPPKHRTEVKRRASRLGELIVDDPPQYRTIQIYQIEKQDLIKPSVYELYMYSSSIFNESDTLRIQKKDPRGLPISHWCKLPAQAGNSRKRIGQWTPIRDPGASKTVSWMRWRLTESGHMTSPASIVVAVLCVRLSDTAGHQKSDRGSTMIPEPVRRKAV" }, { "InterPro": [ { "InterPro-ID": "IPR052646", "InterPro-Name": "Peroxisomal_PEX28-32", "InterPro-Type": "FAMILY", "Beg": 18, "End": 347 }, { "InterPro-ID": "IPR006614", "InterPro-Name": "Peroxin/Ferlin", "InterPro-Type": "DOMAIN", "Beg": 238, "End": 306 }, { "InterPro-ID": "IPR010482", "InterPro-Name": "TECPR1-like_DysF", "InterPro-Type": "DOMAIN", "Beg": 23, "End": 342 } ], "response#1": "MSEPNVRASFADNRRPLSKTKGQLLNMPPVITTALYTAFPVIFLLDKVLAFLTWTNDDPYTNFIAIAIYIMVVKYWTVVACTVLPTIIALGTCASLWFLKTTIDDLRSETAPPTIEEIIDTLINMQARFSYIVEPFSYFGSLSGSDYFNLGFSLIAITPCYIWLMTRIFTVRSFLLVFGVAWLSFHSSWSVATRHLLWRSIVIRKILTFTTGLKFSLVDKNIELTVLNDFQISNVGTGKTVEFHILQNQRRWLGVGWSNTLLPFERGPFTTEDLEKSWDSLESFQFPEITQATCRWRWLDANWKTDDSFAPGEGWIYYNNSWEEPSNTDSLTRFTRTKRWKRRALVIVEDDGTT", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Peroxin/Ferlin, TECPR1-like_DysF that are essential for its biological function; 2. The protein should belong to Peroxisomal_PEX28-32 that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MSEPNVRASFADNRRPLSKTKGQLLNMPPVITTALYTAFPVIFLLDKVLAFLTWTNDDPYTNFIAIAIYIMVVKYWTVVACTVLPTIIALGTCASLWFLKTTIDDLRSETAPPTIEEIIDTLINMQARFSYIVEPFSYFGSLSGSDYFNLGFSLIAITPCYIWLMTRIFTVRSFLLVFGVAWLSFHSSWSVATRHLLWRSIVIRKILTFTTGLKFSLVDKNIELTVLNDFQISNVGTGKTVEFHILQNQRRWLGVGWSNTLLPFERGPFTTEDLEKSWDSLESFQFPEITQATCRWRWLDANWKTDDSFAPGEGWIYYNNSWEEPSNTDSLTRFTRTKRWKRRALVIVEDDGTT" }, { "InterPro": [ { "InterPro-ID": "IPR052816", "InterPro-Name": "Peroxisomal_Membrane_PEX28-32", "InterPro-Type": "FAMILY", "Beg": 35, "End": 498 }, { "InterPro-ID": "IPR010482", "InterPro-Name": "TECPR1-like_DysF", "InterPro-Type": "DOMAIN", "Beg": 123, "End": 493 } ], "response#1": "MESMVNNLWSSWDTLSQATASTGGDMDAASVASKQSPQESKMAASSMIWSSFSEPQKTPPTKRASSSFFDDMFTSSKDHSTTLTDKMFERFLSMALPTTTTQDGEELQSILERIEMQKSRPQLSLNVMSKNAIQLLSRLSVPFVLIDQVIIIFSWSKPLYTLTFLNVATLLILKPILLLSLPFFYTCFEIIVPAYMKRHPPDKHTILQNRNPIPAEGPSVSHVDVPRPVPELSREFVLNSTDLQNHMLLYVMSYDFVTSLIVKYLYFKDENITIFIFVALLTSGTLLTLFGAQVLSAMLPFIKVTLSVGLWAATIAMHPNYRSTLLDMLYSEDTRLRLLMMSNRLELWLNKELNLREQKEVKETEIFELQHLDPETHNWQLICFSSDPYPANSHARLNNLPLLGTLHLSQVKPPEGWKFVDVETAVNTRSVDGWLLDLTPEGWIKENFLNETMDIDEDEKWCYDLVTKFSYQAGLTTNEKKTRGEVRRRRWIRYCVRDIWDEDDQMEETVAHRRNKSMESSNSLHPVKSIDSVDG", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more TECPR1-like_DysF that are essential for its biological function; 2. The protein should belong to Peroxisomal_Membrane_PEX28-32 that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MESMVNNLWSSWDTLSQATASTGGDMDAASVASKQSPQESKMAASSMIWSSFSEPQKTPPTKRASSSFFDDMFTSSKDHSTTLTDKMFERFLSMALPTTTTQDGEELQSILERIEMQKSRPQLSLNVMSKNAIQLLSRLSVPFVLIDQVIIIFSWSKPLYTLTFLNVATLLILKPILLLSLPFFYTCFEIIVPAYMKRHPPDKHTILQNRNPIPAEGPSVSHVDVPRPVPELSREFVLNSTDLQNHMLLYVMSYDFVTSLIVKYLYFKDENITIFIFVALLTSGTLLTLFGAQVLSAMLPFIKVTLSVGLWAATIAMHPNYRSTLLDMLYSEDTRLRLLMMSNRLELWLNKELNLREQKEVKETEIFELQHLDPETHNWQLICFSSDPYPANSHARLNNLPLLGTLHLSQVKPPEGWKFVDVETAVNTRSVDGWLLDLTPEGWIKENFLNETMDIDEDEKWCYDLVTKFSYQAGLTTNEKKTRGEVRRRRWIRYCVRDIWDEDDQMEETVAHRRNKSMESSNSLHPVKSIDSVDG" }, { "InterPro": [ { "InterPro-ID": "IPR013154", "InterPro-Name": "ADH-like_N", "InterPro-Type": "DOMAIN", "Beg": 26, "End": 112 }, { "InterPro-ID": "IPR036291", "InterPro-Name": "NAD(P)-bd_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 115, "End": 322 }, { "InterPro-ID": "IPR020843", "InterPro-Name": "PKS_ER", "InterPro-Type": "DOMAIN", "Beg": 10, "End": 350 }, { "InterPro-ID": "IPR011032", "InterPro-Name": "GroES-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1, "End": 140 }, { "InterPro-ID": "IPR047122", "InterPro-Name": "Trans-enoyl_RdTase-like", "InterPro-Type": "FAMILY", "Beg": 1, "End": 353 } ], "response#1": "MKAIISVSPGRAALVHDRPLPSLRNGYLLVRTKAVALNPTDWKHIEITERPGILFGCDYAGVVEKIGPGISSRFQVGDRVAGFVHGGNSQEPQDGAFAEYILAKADIQILIPEHMSFEEAATLGVGVTSVGQGLYQALQLPFPGTQGEDPKTPTEEQQPLLIYGGSTASGVLGIQFAKLSGFAPLAVCSPDHFDLVETLGAVAQFDYADGEEAVQEIQDYVDRMSKPLRLAWDTVSIPSSAQFCGDALSALDECHYASLLPIKCQRSDVTSTTTMAYTVFGEDWGMGATRFPAVATDAEFGRRWWALVQELLDQGRIQTHRIIIGENGLDGVLAGLERLRDSQVRGAKLVYRV", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more ADH-like_N, PKS_ER that are essential for its biological function; 2. The protein should belong to Trans-enoyl_RdTase-like that shares evolutionary origin and functional similarity; 3. The protein should be classified within NAD(P)-bd_dom_sf, GroES-like_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MKAIISVSPGRAALVHDRPLPSLRNGYLLVRTKAVALNPTDWKHIEITERPGILFGCDYAGVVEKIGPGISSRFQVGDRVAGFVHGGNSQEPQDGAFAEYILAKADIQILIPEHMSFEEAATLGVGVTSVGQGLYQALQLPFPGTQGEDPKTPTEEQQPLLIYGGSTASGVLGIQFAKLSGFAPLAVCSPDHFDLVETLGAVAQFDYADGEEAVQEIQDYVDRMSKPLRLAWDTVSIPSSAQFCGDALSALDECHYASLLPIKCQRSDVTSTTTMAYTVFGEDWGMGATRFPAVATDAEFGRRWWALVQELLDQGRIQTHRIIIGENGLDGVLAGLERLRDSQVRGAKLVYRV" }, { "InterPro": [ { "InterPro-ID": "IPR015221", "InterPro-Name": "Urm1", "InterPro-Type": "FAMILY", "Beg": 12, "End": 110 }, { "InterPro-ID": "IPR012675", "InterPro-Name": "Beta-grasp_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 7, "End": 110 }, { "InterPro-ID": "IPR016155", "InterPro-Name": "Mopterin_synth/thiamin_S_b", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 8, "End": 110 }, { "InterPro-ID": "IPR015221", "InterPro-Name": "Urm1", "InterPro-Type": "FAMILY", "Beg": 8, "End": 110 }, { "InterPro-ID": "IPR015221", "InterPro-Name": "Urm1", "InterPro-Type": "FAMILY", "Beg": 10, "End": 110 } ], "response#1": "MSSKAKLEEIPITVDFSGGLEMLFDNQRRHSISLPAKDTEGKPVTIAFLIDYICKKLMKDPRTDLFVLDNHIRPGILVLINDADWELEGEEAYEIQPNDNILFVSTLHGG", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Urm1, Urm1, Urm1 that shares evolutionary origin and functional similarity; 2. The protein should be classified within Beta-grasp_dom_sf, Mopterin_synth/thiamin_S_b sharing conserved structural features. The designed protein sequence is ", "reference": "MSSKAKLEEIPITVDFSGGLEMLFDNQRRHSISLPAKDTEGKPVTIAFLIDYICKKLMKDPRTDLFVLDNHIRPGILVLINDADWELEGEEAYEIQPNDNILFVSTLHGG" }, { "InterPro": [ { "InterPro-ID": "IPR006638", "InterPro-Name": "Elp3/MiaA/NifB-like_rSAM", "InterPro-Type": "DOMAIN", "Beg": 113, "End": 309 }, { "InterPro-ID": "IPR007197", "InterPro-Name": "rSAM", "InterPro-Type": "DOMAIN", "Beg": 119, "End": 272 }, { "InterPro-ID": "IPR050377", "InterPro-Name": "Radical_SAM_PqqE_MftC-like", "InterPro-Type": "FAMILY", "Beg": 109, "End": 460 }, { "InterPro-ID": "IPR007197", "InterPro-Name": "rSAM", "InterPro-Type": "DOMAIN", "Beg": 118, "End": 464 }, { "InterPro-ID": "IPR007197", "InterPro-Name": "rSAM", "InterPro-Type": "DOMAIN", "Beg": 100, "End": 317 }, { "InterPro-ID": "IPR023885", "InterPro-Name": "4Fe4S-binding_SPASM_dom", "InterPro-Type": "DOMAIN", "Beg": 370, "End": 459 }, { "InterPro-ID": "IPR023867", "InterPro-Name": "Sulphatase_maturase_rSAM", "InterPro-Type": "FAMILY", "Beg": 118, "End": 464 }, { "InterPro-ID": "IPR023885", "InterPro-Name": "4Fe4S-binding_SPASM_dom", "InterPro-Type": "DOMAIN", "Beg": 370, "End": 432 }, { "InterPro-ID": "IPR013785", "InterPro-Name": "Aldolase_TIM", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 114, "End": 422 } ], "response#1": "MKTEDMALVFSKLILNPITKRQILNLFKKDDNGNLIIENYIDAYMKGEDINSLGYKTLKSVLDNGLKTFAGEIYKENFKDFLKDPLFKKGLISVVRGLGYFGVKRPFVSGAPFLVVWDVTYACNLRCKHCYANAGKPLEDELNTEEALKTIDILANSGVVAIAFSGGEPLMRKDLFELIDRAKDYNMQVSIASNGTMLNKTNAKKLKEHKVDFVQISLDGTKETHEKFRGIKGIYDKTIEGIKNVVDEDIFCAIATTATKLNYRDVPKVMDLAEELNVNYFMLYNYIPVGVGDYDIDLSPEEREELLNLLWEKLNNDTGKKYRTAFLSTAPYYSRTALEHNKYYLASHFANVDLGENERLKSLANFIGGCGCGRFYLSLRANGDIQPCVFFPLKLGNIKSFKDENDFLEFWRNNKILNDLRDRDKLKICGSCMYKYVCGGCRARAYSYYDDYLREDPGCILTKNLK", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Elp3/MiaA/NifB-like_rSAM, rSAM, rSAM, rSAM, 4Fe4S-binding_SPASM_dom, 4Fe4S-binding_SPASM_dom that are essential for its biological function; 2. The protein should belong to Radical_SAM_PqqE_MftC-like, Sulphatase_maturase_rSAM that shares evolutionary origin and functional similarity; 3. The protein should be classified within Aldolase_TIM sharing conserved structural features. The designed protein sequence is ", "reference": "MKTEDMALVFSKLILNPITKRQILNLFKKDDNGNLIIENYIDAYMKGEDINSLGYKTLKSVLDNGLKTFAGEIYKENFKDFLKDPLFKKGLISVVRGLGYFGVKRPFVSGAPFLVVWDVTYACNLRCKHCYANAGKPLEDELNTEEALKTIDILANSGVVAIAFSGGEPLMRKDLFELIDRAKDYNMQVSIASNGTMLNKTNAKKLKEHKVDFVQISLDGTKETHEKFRGIKGIYDKTIEGIKNVVDEDIFCAIATTATKLNYRDVPKVMDLAEELNVNYFMLYNYIPVGVGDYDIDLSPEEREELLNLLWEKLNNDTGKKYRTAFLSTAPYYSRTALEHNKYYLASHFANVDLGENERLKSLANFIGGCGCGRFYLSLRANGDIQPCVFFPLKLGNIKSFKDENDFLEFWRNNKILNDLRDRDKLKICGSCMYKYVCGGCRARAYSYYDDYLREDPGCILTKNLK" }, { "InterPro": [ { "InterPro-ID": "IPR036259", "InterPro-Name": "MFS_trans_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1, "End": 196 }, { "InterPro-ID": "IPR036259", "InterPro-Name": "MFS_trans_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 245, "End": 451 }, { "InterPro-ID": "IPR020846", "InterPro-Name": "MFS_dom", "InterPro-Type": "DOMAIN", "Beg": 1, "End": 451 }, { "InterPro-ID": "IPR050930", "InterPro-Name": "MFS_Vesicular_Transporter", "InterPro-Type": "FAMILY", "Beg": 2, "End": 450 }, { "InterPro-ID": "IPR036259", "InterPro-Name": "MFS_trans_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 2, "End": 452 }, { "InterPro-ID": "IPR011701", "InterPro-Name": "MFS", "InterPro-Type": "FAMILY", "Beg": 3, "End": 166 }, { "InterPro-ID": "IPR011701", "InterPro-Name": "MFS", "InterPro-Type": "FAMILY", "Beg": 257, "End": 449 } ], "response#1": "MGLFTDLVLYGIVLPALPFIMRNRFHIPNAELQHYTSGFLATYAGASVFFSVPAGWAASKLGSRQLFLGGLVFLFVATAIFAFSTSLALLVVSRLLQGMSTAVVWTAGLDMVQDTVDPSQIGVTIGTIFATISVGELAAPVLGGVLYERGGIAAVFAVSAVMLAIDLGLRGLVIDKKAAVKFESPCLIRSSAERSDHVASAPTVVEAQERTHEGTPLLPQDDDDDSDRYKIDRELGSIVQAIPLLYCFREPRLHLAMLLSFVQALFIGTFDATVPTEAESLFHFSSLQVGLVFIALMLPYFALGRLAGQAVDRFGTKAAATSGYAFLVPCLLLLGLPEKKLVSKEANVALFCTILALNGIGLAVVTSPGYVEAIDVTTKYQVANPGHFGENGPYAQLFGFSSLYFFTGLAVGPLLGGVLRAKFGYAVMGAVYAAISGVTAIVSFLFVGTRRGVCWG", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more MFS_dom that are essential for its biological function; 2. The protein should belong to MFS_Vesicular_Transporter, MFS, MFS that shares evolutionary origin and functional similarity; 3. The protein should be classified within MFS_trans_sf, MFS_trans_sf, MFS_trans_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MGLFTDLVLYGIVLPALPFIMRNRFHIPNAELQHYTSGFLATYAGASVFFSVPAGWAASKLGSRQLFLGGLVFLFVATAIFAFSTSLALLVVSRLLQGMSTAVVWTAGLDMVQDTVDPSQIGVTIGTIFATISVGELAAPVLGGVLYERGGIAAVFAVSAVMLAIDLGLRGLVIDKKAAVKFESPCLIRSSAERSDHVASAPTVVEAQERTHEGTPLLPQDDDDDSDRYKIDRELGSIVQAIPLLYCFREPRLHLAMLLSFVQALFIGTFDATVPTEAESLFHFSSLQVGLVFIALMLPYFALGRLAGQAVDRFGTKAAATSGYAFLVPCLLLLGLPEKKLVSKEANVALFCTILALNGIGLAVVTSPGYVEAIDVTTKYQVANPGHFGENGPYAQLFGFSSLYFFTGLAVGPLLGGVLRAKFGYAVMGAVYAAISGVTAIVSFLFVGTRRGVCWG" }, { "InterPro": [ { "InterPro-ID": "IPR036259", "InterPro-Name": "MFS_trans_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 237, "End": 476 }, { "InterPro-ID": "IPR020846", "InterPro-Name": "MFS_dom", "InterPro-Type": "DOMAIN", "Beg": 50, "End": 540 }, { "InterPro-ID": "IPR011701", "InterPro-Name": "MFS", "InterPro-Type": "FAMILY", "Beg": 54, "End": 452 }, { "InterPro-ID": "IPR036259", "InterPro-Name": "MFS_trans_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 35, "End": 540 } ], "response#1": "MQTATALEDSANAPSPAASSQGQFDREIVPIDTADAGNSTKRSPLKVALIMVALCCAVFLHALDNTIITTALPTITAAFDLDAAYTWIGSTYLLAVAASTMVWAKISDVFGRKPIILSANLCFFTGSLIAALSANFAMLIAARAIQGIGGAGVNVLANICVGDLFSQRKRGLYYGVIGGVWAVALSLGPVVGGSLTESISWRWCFYINLPLCAVVFVIIILLLDVKTPKTPFGKGIAAIDWVGAALSIGSTLMILLALSLGGQTEPWNSATVICLVVFGFIGWILCFSWEASLAKYPLLPVSIFKQIPTLAVLAACFIQSYAFVASAYYLPLYFQAVLGATPILSGVYLLPTAVSISISSTATGVYMRKTGQYLTPIYIGFVLQTLGYGLFIDLGPTANWAKIIVFQIIGGLGVGFNFQAPMVALQAFISPRELAMATSAYNFMRNVSGAISVVIGQTVFQNEMSKHQESLATILGPQLAAKLAGTGASASTDLIRSLPSPQRDVVHGVFANSMKSMWIMYTAFSAAALVVCPFLGKMVLREDHTETVTGLAAENAAREERLRQEKEKKDAKIRKCQVN", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more MFS_dom that are essential for its biological function; 2. The protein should belong to MFS that shares evolutionary origin and functional similarity; 3. The protein should be classified within MFS_trans_sf, MFS_trans_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MQTATALEDSANAPSPAASSQGQFDREIVPIDTADAGNSTKRSPLKVALIMVALCCAVFLHALDNTIITTALPTITAAFDLDAAYTWIGSTYLLAVAASTMVWAKISDVFGRKPIILSANLCFFTGSLIAALSANFAMLIAARAIQGIGGAGVNVLANICVGDLFSQRKRGLYYGVIGGVWAVALSLGPVVGGSLTESISWRWCFYINLPLCAVVFVIIILLLDVKTPKTPFGKGIAAIDWVGAALSIGSTLMILLALSLGGQTEPWNSATVICLVVFGFIGWILCFSWEASLAKYPLLPVSIFKQIPTLAVLAACFIQSYAFVASAYYLPLYFQAVLGATPILSGVYLLPTAVSISISSTATGVYMRKTGQYLTPIYIGFVLQTLGYGLFIDLGPTANWAKIIVFQIIGGLGVGFNFQAPMVALQAFISPRELAMATSAYNFMRNVSGAISVVIGQTVFQNEMSKHQESLATILGPQLAAKLAGTGASASTDLIRSLPSPQRDVVHGVFANSMKSMWIMYTAFSAAALVVCPFLGKMVLREDHTETVTGLAAENAAREERLRQEKEKKDAKIRKCQVN" }, { "InterPro": [ { "InterPro-ID": "IPR011055", "InterPro-Name": "Dup_hybrid_motif", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 140, "End": 388 }, { "InterPro-ID": "IPR016047", "InterPro-Name": "Peptidase_M23", "InterPro-Type": "DOMAIN", "Beg": 294, "End": 387 }, { "InterPro-ID": "IPR054512", "InterPro-Name": "NMB0315-like_N", "InterPro-Type": "DOMAIN", "Beg": 61, "End": 143 }, { "InterPro-ID": "IPR011055", "InterPro-Name": "Dup_hybrid_motif", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 268, "End": 393 }, { "InterPro-ID": "IPR050570", "InterPro-Name": "Cell_wall_metabolism_enzyme", "InterPro-Type": "FAMILY", "Beg": 20, "End": 390 } ], "response#1": "MAVFPLSAKHRKYALRALAVSIILVSAAYIALTERTERVRPQRVEQNLPPLSWGGSGVQTAYWVQEAVQPGDSLADVLARSGMARDEIARITEKYGGEADLRHLRADQSVHVLVGGDGGAREVQFFTDEDGERNLVALEKKGGIWRRSASEADMKVLPTLRSVVVKTSARGSLARAEVPVEIRESLSGIFAGRFSLDGLKEGDAVRLIYDSLYFHGQQVAAGDILAAEVVKGGTRHQAFYYRSDKEGGGGGNYYDEDGRVLQEKGGFNIEPLVYTRISSPFGYRMHPILHTWRLHTGIDYAAPQGTPVRASADGVITFKGRKGGYGNAVMIRHANGVETLYAHLSAFSQAQGNVRGGEVIGFVGSTGRSTGPHLHYEARINGQPVNPVSVALPTPELTQADKAAFAAQKQKADALLARLRGIPVTVSQSD", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Peptidase_M23, NMB0315-like_N that are essential for its biological function; 2. The protein should belong to Cell_wall_metabolism_enzyme that shares evolutionary origin and functional similarity; 3. The protein should be classified within Dup_hybrid_motif, Dup_hybrid_motif sharing conserved structural features. The designed protein sequence is ", "reference": "MAVFPLSAKHRKYALRALAVSIILVSAAYIALTERTERVRPQRVEQNLPPLSWGGSGVQTAYWVQEAVQPGDSLADVLARSGMARDEIARITEKYGGEADLRHLRADQSVHVLVGGDGGAREVQFFTDEDGERNLVALEKKGGIWRRSASEADMKVLPTLRSVVVKTSARGSLARAEVPVEIRESLSGIFAGRFSLDGLKEGDAVRLIYDSLYFHGQQVAAGDILAAEVVKGGTRHQAFYYRSDKEGGGGGNYYDEDGRVLQEKGGFNIEPLVYTRISSPFGYRMHPILHTWRLHTGIDYAAPQGTPVRASADGVITFKGRKGGYGNAVMIRHANGVETLYAHLSAFSQAQGNVRGGEVIGFVGSTGRSTGPHLHYEARINGQPVNPVSVALPTPELTQADKAAFAAQKQKADALLARLRGIPVTVSQSD" }, { "InterPro": [ { "InterPro-ID": "IPR020803", "InterPro-Name": "MeTfrase_dom", "InterPro-Type": "DOMAIN", "Beg": 29, "End": 278 }, { "InterPro-ID": "IPR029063", "InterPro-Name": "SAM-dependent_MTases_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 15, "End": 278 }, { "InterPro-ID": "IPR029063", "InterPro-Name": "SAM-dependent_MTases_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 11, "End": 278 }, { "InterPro-ID": "IPR050447", "InterPro-Name": "Erg6_SMT_methyltransf", "InterPro-Type": "FAMILY", "Beg": 15, "End": 179 }, { "InterPro-ID": "IPR013216", "InterPro-Name": "Methyltransf_11", "InterPro-Type": "DOMAIN", "Beg": 75, "End": 173 } ], "response#1": "MGPANSEGTMFDAFSREVGDYYDQANELLRAMFTDNVHYGYWPDPSSIDPLAEAGERMTEQLYERLDVSAGHKVLDVGCGVGKPAAWLARKTGATVKGANVSRNQLEVARDRVRSEGLEDRVSFDLADAMHLPYADDSFDRIWAIESMIHMPDRDQVMREMARVLRPGGRLAIADIVVRGTLDDVATAVVEGFCTLSTARSLEHIDNYPALVEKAGLDLLELTDVSEQTRPTGPAVLPAFDVLLPTLGEEGVAQSKKAWGDMFDLPQYGYVLLTAGKP", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more MeTfrase_dom, Methyltransf_11 that are essential for its biological function; 2. The protein should belong to Erg6_SMT_methyltransf that shares evolutionary origin and functional similarity; 3. The protein should be classified within SAM-dependent_MTases_sf, SAM-dependent_MTases_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MGPANSEGTMFDAFSREVGDYYDQANELLRAMFTDNVHYGYWPDPSSIDPLAEAGERMTEQLYERLDVSAGHKVLDVGCGVGKPAAWLARKTGATVKGANVSRNQLEVARDRVRSEGLEDRVSFDLADAMHLPYADDSFDRIWAIESMIHMPDRDQVMREMARVLRPGGRLAIADIVVRGTLDDVATAVVEGFCTLSTARSLEHIDNYPALVEKAGLDLLELTDVSEQTRPTGPAVLPAFDVLLPTLGEEGVAQSKKAWGDMFDLPQYGYVLLTAGKP" }, { "InterPro": [ { "InterPro-ID": "IPR000917", "InterPro-Name": "Sulfatase_N", "InterPro-Type": "DOMAIN", "Beg": 59, "End": 261 }, { "InterPro-ID": "IPR017850", "InterPro-Name": "Alkaline_phosphatase_core_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 46, "End": 322 }, { "InterPro-ID": "IPR017850", "InterPro-Name": "Alkaline_phosphatase_core_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 28, "End": 321 } ], "response#1": "MTDDQDVHLNSLDFQPISLLSFEGVAPYGPSCAQHKCHRCGPVLIDPGTCVYNNASMVLDNGAWAFHPGSYSTDLVANRSVEFLGDAIKAGEPFFLGVTPIAPHAETVGDAFEAPVPAKRHENLFLDVKVPRSPSFNAGAAGAVGYFRNLPKLAHDQIDYMDTFYRRRLQSLQAVDDLIEDIMAKLESHPDVLANTYLFYTSDNGYHIGQHRLPPGKTCGIEEDVNIPFIARGPGIAAGHVGRFPTSHTDLVPTIFELAGIPLRDEFDGEPMPLKGQRQSNDALNRNTYKTLRVDTDDYAFMYTVWCTNEHELYDMKMNNLYGSNSTTSSFDIPQLSARLDTLLLTLKACKGIACRRPWQTLFPTGNVNGLVDAMDPLHDSFFLVSQPRVTFTTCSLGYNAEVEGPLSPVIFGAADETAIEPRQ", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Sulfatase_N that are essential for its biological function; 2. The protein should be classified within Alkaline_phosphatase_core_sf, Alkaline_phosphatase_core_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MTDDQDVHLNSLDFQPISLLSFEGVAPYGPSCAQHKCHRCGPVLIDPGTCVYNNASMVLDNGAWAFHPGSYSTDLVANRSVEFLGDAIKAGEPFFLGVTPIAPHAETVGDAFEAPVPAKRHENLFLDVKVPRSPSFNAGAAGAVGYFRNLPKLAHDQIDYMDTFYRRRLQSLQAVDDLIEDIMAKLESHPDVLANTYLFYTSDNGYHIGQHRLPPGKTCGIEEDVNIPFIARGPGIAAGHVGRFPTSHTDLVPTIFELAGIPLRDEFDGEPMPLKGQRQSNDALNRNTYKTLRVDTDDYAFMYTVWCTNEHELYDMKMNNLYGSNSTTSSFDIPQLSARLDTLLLTLKACKGIACRRPWQTLFPTGNVNGLVDAMDPLHDSFFLVSQPRVTFTTCSLGYNAEVEGPLSPVIFGAADETAIEPRQ" }, { "InterPro": [ { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 7, "End": 337 }, { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 11, "End": 331 }, { "InterPro-ID": "IPR053226", "InterPro-Name": "Pyrrolopyrazine_biosynth_F", "InterPro-Type": "FAMILY", "Beg": 3, "End": 338 } ], "response#1": "MSANTGKPARHYLISYPRTASNLLLKILALDSQPNFSSGGFDGGYFFMPADDILTDPRIRVRARSISDWTADERAQLKETFQACFEAQQRWLESAESQGQSVFVKEHTVFFADPTARSCLQFGPSATSEPAWTVEYAGGSTHSKLNITVLPDEFLLTWLPTFLIRHPALAFPSLYRTVIKREGKESAAADNFASLLTTVEWSRSLYDFYVQNRESLPCSPDQRLEWPIVLDADDIIAHPATVTLYCDKIGMDPRQLCFNWDQLKSEELSKIEPNQLAMRMSLYQSTGIDTSKSSRGINVDDEATKWRSEFGIAVADHIEKLVRGAMADYEYLRARRLRAD", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Pyrrolopyrazine_biosynth_F that shares evolutionary origin and functional similarity; 2. The protein should be classified within P-loop_NTPase, P-loop_NTPase sharing conserved structural features. The designed protein sequence is ", "reference": "MSANTGKPARHYLISYPRTASNLLLKILALDSQPNFSSGGFDGGYFFMPADDILTDPRIRVRARSISDWTADERAQLKETFQACFEAQQRWLESAESQGQSVFVKEHTVFFADPTARSCLQFGPSATSEPAWTVEYAGGSTHSKLNITVLPDEFLLTWLPTFLIRHPALAFPSLYRTVIKREGKESAAADNFASLLTTVEWSRSLYDFYVQNRESLPCSPDQRLEWPIVLDADDIIAHPATVTLYCDKIGMDPRQLCFNWDQLKSEELSKIEPNQLAMRMSLYQSTGIDTSKSSRGINVDDEATKWRSEFGIAVADHIEKLVRGAMADYEYLRARRLRAD" }, { "InterPro": [ { "InterPro-ID": "IPR044925", "InterPro-Name": "His-Me_finger_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 129, "End": 380 }, { "InterPro-ID": "IPR044929", "InterPro-Name": "DNA/RNA_non-sp_Endonuclease_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 136, "End": 386 }, { "InterPro-ID": "IPR001604", "InterPro-Name": "Endo_G_ENPP1-like_dom", "InterPro-Type": "DOMAIN", "Beg": 139, "End": 377 }, { "InterPro-ID": "IPR040255", "InterPro-Name": "Non-specific_endonuclease", "InterPro-Type": "FAMILY", "Beg": 78, "End": 378 }, { "InterPro-ID": "IPR001604", "InterPro-Name": "Endo_G_ENPP1-like_dom", "InterPro-Type": "DOMAIN", "Beg": 144, "End": 379 } ], "response#1": "MALKLVYGVFTLALLGISSVNADCSLKIPESVENEKTPVIMVRKSLKTFEYDLFQPTGEVTNFPERTELLLACTGAQNYFKNGEESVTLMCHNNEFDDGQGNGLDLFTCVKTPTAELRKTKERCSLGDLYVYDVVFRISEEELVGPVYDICYNEYSQKPAYSRNIINGAAVNYRVPESETDLTVSLAKDFTTRDVNNYFKLENQKQRFQGYTIDGKPLVDDKNFFAPGQLAPDTSMITPADKLSTYDYANIVPQYKTVYDGNVWRVENITRDLAVNRQAKFEVYTGGYERLTALHNGKEEEIFLSAKKYVHEIPKYIYKFVVDKENDAGIVFFTLNNPHVKNVKGTEFCKNQCEEANVLDSNFKDWTQGYTFCCTWNNVKDYVRALPQDIEINNLLKFN", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Endo_G_ENPP1-like_dom, Endo_G_ENPP1-like_dom that are essential for its biological function; 2. The protein should belong to Non-specific_endonuclease that shares evolutionary origin and functional similarity; 3. The protein should be classified within His-Me_finger_sf, DNA/RNA_non-sp_Endonuclease_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MALKLVYGVFTLALLGISSVNADCSLKIPESVENEKTPVIMVRKSLKTFEYDLFQPTGEVTNFPERTELLLACTGAQNYFKNGEESVTLMCHNNEFDDGQGNGLDLFTCVKTPTAELRKTKERCSLGDLYVYDVVFRISEEELVGPVYDICYNEYSQKPAYSRNIINGAAVNYRVPESETDLTVSLAKDFTTRDVNNYFKLENQKQRFQGYTIDGKPLVDDKNFFAPGQLAPDTSMITPADKLSTYDYANIVPQYKTVYDGNVWRVENITRDLAVNRQAKFEVYTGGYERLTALHNGKEEEIFLSAKKYVHEIPKYIYKFVVDKENDAGIVFFTLNNPHVKNVKGTEFCKNQCEEANVLDSNFKDWTQGYTFCCTWNNVKDYVRALPQDIEINNLLKFN" }, { "InterPro": [ { "InterPro-ID": "IPR056799", "InterPro-Name": "ALL3/gSG7_salivary-like_helix", "InterPro-Type": "DOMAIN", "Beg": 176, "End": 281 } ], "response#1": "MKKFCLIFLLLALTALHVKGSPIPDEESEETEDAEQEEDAEEEEHAEEEAQEDGDQTQDTDQESDDGQEETANQGSDEQQEEDGSHGTDETDDEAAGSRTEDVESGGDEQNDGEENGSQENGEEVTGGEDDSHGAQDSEGGEEDAAAQEAGGKKSKGKGAKGGQGSNRAGSSSGGEESAAHTYQEVMRILNGIKINAKEPLKSRLVNGLQYLKVDTINRVENIQKFSRIEHCFGNLDHIVQLYAGDAVERNDYCKGTCIDMVSNEFRGQMEELTSRLYPCLQGGYY", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more ALL3/gSG7_salivary-like_helix that are essential for its biological function. The designed protein sequence is ", "reference": "MKKFCLIFLLLALTALHVKGSPIPDEESEETEDAEQEEDAEEEEHAEEEAQEDGDQTQDTDQESDDGQEETANQGSDEQQEEDGSHGTDETDDEAAGSRTEDVESGGDEQNDGEENGSQENGEEVTGGEDDSHGAQDSEGGEEDAAAQEAGGKKSKGKGAKGGQGSNRAGSSSGGEESAAHTYQEVMRILNGIKINAKEPLKSRLVNGLQYLKVDTINRVENIQKFSRIEHCFGNLDHIVQLYAGDAVERNDYCKGTCIDMVSNEFRGQMEELTSRLYPCLQGGYY" }, { "InterPro": [ { "InterPro-ID": "IPR006212", "InterPro-Name": "Furin_repeat", "InterPro-Type": "REPEAT", "Beg": 645, "End": 693 }, { "InterPro-ID": "IPR006212", "InterPro-Name": "Furin_repeat", "InterPro-Type": "REPEAT", "Beg": 166, "End": 214 }, { "InterPro-ID": "IPR009030", "InterPro-Name": "Growth_fac_rcpt_cys_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 606, "End": 735 }, { "InterPro-ID": "IPR006212", "InterPro-Name": "Furin_repeat", "InterPro-Type": "REPEAT", "Beg": 323, "End": 361 }, { "InterPro-ID": "IPR006212", "InterPro-Name": "Furin_repeat", "InterPro-Type": "REPEAT", "Beg": 695, "End": 730 }, { "InterPro-ID": "IPR009030", "InterPro-Name": "Growth_fac_rcpt_cys_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 27, "End": 154 }, { "InterPro-ID": "IPR009030", "InterPro-Name": "Growth_fac_rcpt_cys_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 107, "End": 277 }, { "InterPro-ID": "IPR006212", "InterPro-Name": "Furin_repeat", "InterPro-Type": "REPEAT", "Beg": 824, "End": 867 }, { "InterPro-ID": "IPR006212", "InterPro-Name": "Furin_repeat", "InterPro-Type": "REPEAT", "Beg": 690, "End": 739 }, { "InterPro-ID": "IPR006212", "InterPro-Name": "Furin_repeat", "InterPro-Type": "REPEAT", "Beg": 210, "End": 263 }, { "InterPro-ID": "IPR006212", "InterPro-Name": "Furin_repeat", "InterPro-Type": "REPEAT", "Beg": 53, "End": 98 }, { "InterPro-ID": "IPR006212", "InterPro-Name": "Furin_repeat", "InterPro-Type": "REPEAT", "Beg": 554, "End": 602 }, { "InterPro-ID": "IPR006212", "InterPro-Name": "Furin_repeat", "InterPro-Type": "REPEAT", "Beg": 267, "End": 315 }, { "InterPro-ID": "IPR006212", "InterPro-Name": "Furin_repeat", "InterPro-Type": "REPEAT", "Beg": 427, "End": 492 }, { "InterPro-ID": "IPR006212", "InterPro-Name": "Furin_repeat", "InterPro-Type": "REPEAT", "Beg": 818, "End": 865 }, { "InterPro-ID": "IPR006212", "InterPro-Name": "Furin_repeat", "InterPro-Type": "REPEAT", "Beg": 373, "End": 422 }, { "InterPro-ID": "IPR006212", "InterPro-Name": "Furin_repeat", "InterPro-Type": "REPEAT", "Beg": 606, "End": 639 }, { "InterPro-ID": "IPR006212", "InterPro-Name": "Furin_repeat", "InterPro-Type": "REPEAT", "Beg": 317, "End": 362 }, { "InterPro-ID": "IPR006212", "InterPro-Name": "Furin_repeat", "InterPro-Type": "REPEAT", "Beg": 104, "End": 151 }, { "InterPro-ID": "IPR006212", "InterPro-Name": "Furin_repeat", "InterPro-Type": "REPEAT", "Beg": 161, "End": 208 }, { "InterPro-ID": "IPR006212", "InterPro-Name": "Furin_repeat", "InterPro-Type": "REPEAT", "Beg": 640, "End": 686 }, { "InterPro-ID": "IPR006212", "InterPro-Name": "Furin_repeat", "InterPro-Type": "REPEAT", "Beg": 496, "End": 546 }, { "InterPro-ID": "IPR006212", "InterPro-Name": "Furin_repeat", "InterPro-Type": "REPEAT", "Beg": 760, "End": 814 }, { "InterPro-ID": "IPR006212", "InterPro-Name": "Furin_repeat", "InterPro-Type": "REPEAT", "Beg": 109, "End": 155 }, { "InterPro-ID": "IPR009030", "InterPro-Name": "Growth_fac_rcpt_cys_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 268, "End": 441 }, { "InterPro-ID": "IPR009030", "InterPro-Name": "Growth_fac_rcpt_cys_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 428, "End": 621 }, { "InterPro-ID": "IPR006212", "InterPro-Name": "Furin_repeat", "InterPro-Type": "REPEAT", "Beg": 59, "End": 105 }, { "InterPro-ID": "IPR009030", "InterPro-Name": "Growth_fac_rcpt_cys_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 723, "End": 885 }, { "InterPro-ID": "IPR000742", "InterPro-Name": "EGF-like_dom", "InterPro-Type": "DOMAIN", "Beg": 272, "End": 306 }, { "InterPro-ID": "IPR000742", "InterPro-Name": "EGF-like_dom", "InterPro-Type": "DOMAIN", "Beg": 215, "End": 254 }, { "InterPro-ID": "IPR000742", "InterPro-Name": "EGF-like_dom", "InterPro-Type": "DOMAIN", "Beg": 645, "End": 676 }, { "InterPro-ID": "IPR000742", "InterPro-Name": "EGF-like_dom", "InterPro-Type": "DOMAIN", "Beg": 166, "End": 199 }, { "InterPro-ID": "IPR000742", "InterPro-Name": "EGF-like_dom", "InterPro-Type": "DOMAIN", "Beg": 322, "End": 353 }, { "InterPro-ID": "IPR000742", "InterPro-Name": "EGF-like_dom", "InterPro-Type": "DOMAIN", "Beg": 695, "End": 727 }, { "InterPro-ID": "IPR000742", "InterPro-Name": "EGF-like_dom", "InterPro-Type": "DOMAIN", "Beg": 109, "End": 142 }, { "InterPro-ID": "IPR000742", "InterPro-Name": "EGF-like_dom", "InterPro-Type": "DOMAIN", "Beg": 559, "End": 592 }, { "InterPro-ID": "IPR000742", "InterPro-Name": "EGF-like_dom", "InterPro-Type": "DOMAIN", "Beg": 611, "End": 644 }, { "InterPro-ID": "IPR000742", "InterPro-Name": "EGF-like_dom", "InterPro-Type": "DOMAIN", "Beg": 823, "End": 856 }, { "InterPro-ID": "IPR000742", "InterPro-Name": "EGF-like_dom", "InterPro-Type": "DOMAIN", "Beg": 58, "End": 88 }, { "InterPro-ID": "IPR000742", "InterPro-Name": "EGF-like_dom", "InterPro-Type": "DOMAIN", "Beg": 1187, "End": 1224 }, { "InterPro-ID": "IPR000742", "InterPro-Name": "EGF-like_dom", "InterPro-Type": "DOMAIN", "Beg": 1212, "End": 1223 }, { "InterPro-ID": "IPR000742", "InterPro-Name": "EGF-like_dom", "InterPro-Type": "DOMAIN", "Beg": 1184, "End": 1224 } ], "response#1": "MKFKKELINILALIFVLKKNIFAQSICPTGYQMTQGSCTAIQCPNGQYYDSNLGLCANCDQACSACNYYPTYCTQCQNGFYLYQNQCLTQCPQAQTYVSCSGSSCICQACDSSCTQCFGNKNTQCLACSVGFYYNQINSSCLKQCEDGYTQQIVNIGASQQLLCIPCDNNCRTCSQTNAQQCLTCKDNMYLNTATNQCVSTCPQLQYKINGICKICPTGCQTCYNTNPSNPSTVESCLSCVSGYFLDIENQLCVKNCVSGYVVDAATQRCLPCNATCKNCSDQTNQGCLQCQNGYSLTSGSPSSCQNNCPNGNYQNSSLCLSCNTACSECFGADNQQCTACKTGYYLYKTQCLVICPVGFYTFARQYADPLKQPICDYCPNEMEQCEQDKSNFDLIKPILCKRGYYLYNGTCVKTCPDQTYYQDEATRSCLPCVFPCQTCLSASVCLTCATYTPNGQVQGQTYIFAQITYNGPQGTVFQQNCVPACPKGFYQNSKNNSCQVCNQQCQTCQGPAQTDCITCQIYDSNNMLFKYNNQCYYTCPSSQNNPMYGDKTTQACLPCSQECSSCFNGNNKSCYSCMNGYFLEYLKPECKSFCASDGTYMNSSTNQCSLCGFGCSSCTNGTFNSCISCLNGYYLQQNYNVCYPCPQQCASCTDMNTCQSCNQGYFLYSQTNSCVQQCPLIGFYVDTTQQACIPCDASCLECYGGANNQCISCPKGSYLKTDGTCQQCSQCSSNNECLGPNITDCLNQPICKPGQYLYDGQCLTCFPYCSTCSGTTYDSCISCQTTTDYTLLFDVCKKKVSQTDTQCDIGFYYDSVNKQCYSCHQNCIQCFGKSSSQCTKCSSGYLLHLDITTCSSTCLDGYYQQDPSIPQCSPCLYNCINGCSSGYQFLLGLCFTQCPFGTTAQKENCSFNSKPSIQFAQNLGNSVNNNSQTISLQLLVYSKNLFSIKWRLFTGNTDISNGPIQSYIQNRFDYIVFPPKSLQSNTQYTIQASILDLANNCQNENDCMVQQTFQTMNAITKGNFNIEINSAYLQLTLIISGWLFNSVPDNISFDLYVKLTGNDYFFFDKGQNYQDGRFTYLIPNLSYDLQDNKAQFFLVIYNDFDVQIQQLLIALNLNLQQTTISIDEFLDSVYSKITTLQQIQSLSYQFYSQMQNLMSSQTTSQTIFNRHLFYQVYSSLKGVQIPCDSNINCSGNGKCLWSQDNYNEILCICNINYAGRYCEFQSYQLDIARQHLIALTDLISNIPLNKSSDLFFTIEVLLELTYFYSIFDEFTLNTLINVYFQVFNQLQRVQSNISDEKILFKISKLTSQLINLINEDQTLSYNDQQSLLMKTMNDFDSQINLYLQNFAKSFDDLKSQEQVQTSFQTDISNINLNLIYQNDLLDAFMSNNGASDGQQQTPIVFYGDQISYTFDITQFSPKSSLSTAVIKWNSNPFLSQSQYQAPFISCITELVIYSQQTEIQISTVSQIVEIAIPKILPTPILSVIRPFYQPYTCIYFDSVSQVYKQDGVQYLRENSTHVICGSEQISGNYGVIVNQEYIDPNLSLTVIWNATQQIYANDQQFINFINQLINSNNNNGTNENPQVSQSSFNPNLSLLYALLIYIIFITIFIVISIIRDRKDQETYIKESDSYWLVHPIYSLIFGPYSSFFPRLQRSINYAQLIINLFLYNAIFVLVYSLPSEQELQQNVGKRQIISIQISSTSVACSIVTYYLTICMVNLFKMKWYIKQKWLDFKQDKITTEIVEQVTKSLKIFHLMNYGLVFMLQAGMGIPIIILILSFNSQQNQFFFTSVFASFVIDNILDIIILISFCFIKIFSQSEKSKIILLFTLRGFYYPVYEFLDIEDKIKEYQQKGEVLPAEEANNQSDDEDIFEINDHMNTPKRIFKKNEEKIDKAQEEIQLNEFVNNLKTNQ", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more EGF-like_dom, EGF-like_dom, EGF-like_dom, EGF-like_dom, EGF-like_dom, EGF-like_dom, EGF-like_dom, EGF-like_dom, EGF-like_dom, EGF-like_dom, EGF-like_dom, EGF-like_dom, EGF-like_dom, EGF-like_dom that are essential for its biological function; 2. The protein should be classified within Growth_fac_rcpt_cys_sf, Growth_fac_rcpt_cys_sf, Growth_fac_rcpt_cys_sf, Growth_fac_rcpt_cys_sf, Growth_fac_rcpt_cys_sf, Growth_fac_rcpt_cys_sf sharing conserved structural features; 3. The protein should include one or more Furin_repeat, Furin_repeat, Furin_repeat, Furin_repeat, Furin_repeat, Furin_repeat, Furin_repeat, Furin_repeat, Furin_repeat, Furin_repeat, Furin_repeat, Furin_repeat, Furin_repeat, Furin_repeat, Furin_repeat, Furin_repeat, Furin_repeat, Furin_repeat, Furin_repeat, Furin_repeat, Furin_repeat, Furin_repeat that provide structural or functional support. The designed protein sequence is ", "reference": "MKFKKELINILALIFVLKKNIFAQSICPTGYQMTQGSCTAIQCPNGQYYDSNLGLCANCDQACSACNYYPTYCTQCQNGFYLYQNQCLTQCPQAQTYVSCSGSSCICQACDSSCTQCFGNKNTQCLACSVGFYYNQINSSCLKQCEDGYTQQIVNIGASQQLLCIPCDNNCRTCSQTNAQQCLTCKDNMYLNTATNQCVSTCPQLQYKINGICKICPTGCQTCYNTNPSNPSTVESCLSCVSGYFLDIENQLCVKNCVSGYVVDAATQRCLPCNATCKNCSDQTNQGCLQCQNGYSLTSGSPSSCQNNCPNGNYQNSSLCLSCNTACSECFGADNQQCTACKTGYYLYKTQCLVICPVGFYTFARQYADPLKQPICDYCPNEMEQCEQDKSNFDLIKPILCKRGYYLYNGTCVKTCPDQTYYQDEATRSCLPCVFPCQTCLSASVCLTCATYTPNGQVQGQTYIFAQITYNGPQGTVFQQNCVPACPKGFYQNSKNNSCQVCNQQCQTCQGPAQTDCITCQIYDSNNMLFKYNNQCYYTCPSSQNNPMYGDKTTQACLPCSQECSSCFNGNNKSCYSCMNGYFLEYLKPECKSFCASDGTYMNSSTNQCSLCGFGCSSCTNGTFNSCISCLNGYYLQQNYNVCYPCPQQCASCTDMNTCQSCNQGYFLYSQTNSCVQQCPLIGFYVDTTQQACIPCDASCLECYGGANNQCISCPKGSYLKTDGTCQQCSQCSSNNECLGPNITDCLNQPICKPGQYLYDGQCLTCFPYCSTCSGTTYDSCISCQTTTDYTLLFDVCKKKVSQTDTQCDIGFYYDSVNKQCYSCHQNCIQCFGKSSSQCTKCSSGYLLHLDITTCSSTCLDGYYQQDPSIPQCSPCLYNCINGCSSGYQFLLGLCFTQCPFGTTAQKENCSFNSKPSIQFAQNLGNSVNNNSQTISLQLLVYSKNLFSIKWRLFTGNTDISNGPIQSYIQNRFDYIVFPPKSLQSNTQYTIQASILDLANNCQNENDCMVQQTFQTMNAITKGNFNIEINSAYLQLTLIISGWLFNSVPDNISFDLYVKLTGNDYFFFDKGQNYQDGRFTYLIPNLSYDLQDNKAQFFLVIYNDFDVQIQQLLIALNLNLQQTTISIDEFLDSVYSKITTLQQIQSLSYQFYSQMQNLMSSQTTSQTIFNRHLFYQVYSSLKGVQIPCDSNINCSGNGKCLWSQDNYNEILCICNINYAGRYCEFQSYQLDIARQHLIALTDLISNIPLNKSSDLFFTIEVLLELTYFYSIFDEFTLNTLINVYFQVFNQLQRVQSNISDEKILFKISKLTSQLINLINEDQTLSYNDQQSLLMKTMNDFDSQINLYLQNFAKSFDDLKSQEQVQTSFQTDISNINLNLIYQNDLLDAFMSNNGASDGQQQTPIVFYGDQISYTFDITQFSPKSSLSTAVIKWNSNPFLSQSQYQAPFISCITELVIYSQQTEIQISTVSQIVEIAIPKILPTPILSVIRPFYQPYTCIYFDSVSQVYKQDGVQYLRENSTHVICGSEQISGNYGVIVNQEYIDPNLSLTVIWNATQQIYANDQQFINFINQLINSNNNNGTNENPQVSQSSFNPNLSLLYALLIYIIFITIFIVISIIRDRKDQETYIKESDSYWLVHPIYSLIFGPYSSFFPRLQRSINYAQLIINLFLYNAIFVLVYSLPSEQELQQNVGKRQIISIQISSTSVACSIVTYYLTICMVNLFKMKWYIKQKWLDFKQDKITTEIVEQVTKSLKIFHLMNYGLVFMLQAGMGIPIIILILSFNSQQNQFFFTSVFASFVIDNILDIIILISFCFIKIFSQSEKSKIILLFTLRGFYYPVYEFLDIEDKIKEYQQKGEVLPAEEANNQSDDEDIFEINDHMNTPKRIFKKNEEKIDKAQEEIQLNEFVNNLKTNQ" }, { "InterPro": [ { "InterPro-ID": "IPR008567", "InterPro-Name": "BKACE", "InterPro-Type": "FAMILY", "Beg": 1, "End": 274 }, { "InterPro-ID": "IPR013785", "InterPro-Name": "Aldolase_TIM", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1, "End": 277 }, { "InterPro-ID": "IPR008567", "InterPro-Name": "BKACE", "InterPro-Type": "FAMILY", "Beg": 4, "End": 273 } ], "response#1": "MTQPCIISVAITGSLPRKRDNPAVPITVSEQVESTQAAFEAGATLVHLHVRNDDETPSSEPDRFARVLEGIRKHAPGIITQVSTGGRSGAGRERGGMLSLRPDMASLATGSVNFPTRVYDNPPDLVDWLAAEMKAYAIKPEIEAFDLSMIFQAVAMQQAGKIDGALHIQFVMGIKNAMPVDREVLAFYVHTLRRLAPDATWTGAGIGRDQLTMARWSLELGGHCRTGLEDNVRLDKQTLAPSNAALVSQVAALCEEYGRPVATVAQARALLGLPSMEIDGRSPW", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to BKACE, BKACE that shares evolutionary origin and functional similarity; 2. The protein should be classified within Aldolase_TIM sharing conserved structural features. The designed protein sequence is ", "reference": "MTQPCIISVAITGSLPRKRDNPAVPITVSEQVESTQAAFEAGATLVHLHVRNDDETPSSEPDRFARVLEGIRKHAPGIITQVSTGGRSGAGRERGGMLSLRPDMASLATGSVNFPTRVYDNPPDLVDWLAAEMKAYAIKPEIEAFDLSMIFQAVAMQQAGKIDGALHIQFVMGIKNAMPVDREVLAFYVHTLRRLAPDATWTGAGIGRDQLTMARWSLELGGHCRTGLEDNVRLDKQTLAPSNAALVSQVAALCEEYGRPVATVAQARALLGLPSMEIDGRSPW" }, { "InterPro": [ { "InterPro-ID": "IPR017996", "InterPro-Name": "Royal_jelly/protein_yellow", "InterPro-Type": "FAMILY", "Beg": 19, "End": 397 }, { "InterPro-ID": "IPR011042", "InterPro-Name": "6-blade_b-propeller_TolB-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 21, "End": 398 }, { "InterPro-ID": "IPR017996", "InterPro-Name": "Royal_jelly/protein_yellow", "InterPro-Type": "FAMILY", "Beg": 104, "End": 394 } ], "response#1": "MKFILSVLALASFQHVFCDDVERAYAWRNISFVDTREGTYNPEDVIPTGVTHDAKTKKLYFGVPRLYPNIPYTLAEIDTNKYNSSEIRSPPFSKFNSQGGKEFTSIYQPVIDDCRRLWVLDVGEADYKKNGNEYPTKNPEIIAFDLNQEGNPEVHRYKLEGDVAKTPLGFGGFAVDVLNPNGNCATSDETYLYITNFIDNALIVYDMKNRNAWKINDDSFKPEPGKSVFNHKGEEYTYSVGIFGITLGDRDKDGHRLAYYLAGSSTKVYNVNTANLKKKVKSLKPTLLGERGYKTEAIALAYDPKTKVIFFAESDSRQVSCWNIQKDLKPENVGVIYTNAYFVFGTDIMVDADSTLWFMSNAHPPTKIPKLEFDKRQIRLMKVPTHRAIRNLPCEMRKA", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Royal_jelly/protein_yellow, Royal_jelly/protein_yellow that shares evolutionary origin and functional similarity; 2. The protein should be classified within 6-blade_b-propeller_TolB-like sharing conserved structural features. The designed protein sequence is ", "reference": "MKFILSVLALASFQHVFCDDVERAYAWRNISFVDTREGTYNPEDVIPTGVTHDAKTKKLYFGVPRLYPNIPYTLAEIDTNKYNSSEIRSPPFSKFNSQGGKEFTSIYQPVIDDCRRLWVLDVGEADYKKNGNEYPTKNPEIIAFDLNQEGNPEVHRYKLEGDVAKTPLGFGGFAVDVLNPNGNCATSDETYLYITNFIDNALIVYDMKNRNAWKINDDSFKPEPGKSVFNHKGEEYTYSVGIFGITLGDRDKDGHRLAYYLAGSSTKVYNVNTANLKKKVKSLKPTLLGERGYKTEAIALAYDPKTKVIFFAESDSRQVSCWNIQKDLKPENVGVIYTNAYFVFGTDIMVDADSTLWFMSNAHPPTKIPKLEFDKRQIRLMKVPTHRAIRNLPCEMRKA" }, { "InterPro": [ { "InterPro-ID": "IPR018247", "InterPro-Name": "EF_Hand_1_Ca_BS", "InterPro-Type": "BINDING_SITE", "Beg": 166, "End": 178 }, { "InterPro-ID": "IPR002048", "InterPro-Name": "EF_hand_dom", "InterPro-Type": "DOMAIN", "Beg": 156, "End": 217 }, { "InterPro-ID": "IPR002048", "InterPro-Name": "EF_hand_dom", "InterPro-Type": "DOMAIN", "Beg": 80, "End": 140 }, { "InterPro-ID": "IPR002048", "InterPro-Name": "EF_hand_dom", "InterPro-Type": "DOMAIN", "Beg": 153, "End": 188 }, { "InterPro-ID": "IPR011992", "InterPro-Name": "EF-hand-dom_pair", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 78, "End": 217 }, { "InterPro-ID": "IPR011992", "InterPro-Name": "EF-hand-dom_pair", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 191, "End": 290 }, { "InterPro-ID": "IPR002048", "InterPro-Name": "EF_hand_dom", "InterPro-Type": "DOMAIN", "Beg": 231, "End": 259 }, { "InterPro-ID": "IPR002048", "InterPro-Name": "EF_hand_dom", "InterPro-Type": "DOMAIN", "Beg": 117, "End": 145 }, { "InterPro-ID": "IPR002048", "InterPro-Name": "EF_hand_dom", "InterPro-Type": "DOMAIN", "Beg": 81, "End": 109 }, { "InterPro-ID": "IPR002048", "InterPro-Name": "EF_hand_dom", "InterPro-Type": "DOMAIN", "Beg": 157, "End": 185 }, { "InterPro-ID": "IPR002048", "InterPro-Name": "EF_hand_dom", "InterPro-Type": "DOMAIN", "Beg": 194, "End": 222 }, { "InterPro-ID": "IPR018247", "InterPro-Name": "EF_Hand_1_Ca_BS", "InterPro-Type": "BINDING_SITE", "Beg": 240, "End": 252 }, { "InterPro-ID": "IPR002048", "InterPro-Name": "EF_hand_dom", "InterPro-Type": "DOMAIN", "Beg": 113, "End": 148 }, { "InterPro-ID": "IPR002048", "InterPro-Name": "EF_hand_dom", "InterPro-Type": "DOMAIN", "Beg": 234, "End": 255 }, { "InterPro-ID": "IPR018247", "InterPro-Name": "EF_Hand_1_Ca_BS", "InterPro-Type": "BINDING_SITE", "Beg": 203, "End": 215 }, { "InterPro-ID": "IPR002048", "InterPro-Name": "EF_hand_dom", "InterPro-Type": "DOMAIN", "Beg": 227, "End": 262 }, { "InterPro-ID": "IPR018247", "InterPro-Name": "EF_Hand_1_Ca_BS", "InterPro-Type": "BINDING_SITE", "Beg": 126, "End": 138 }, { "InterPro-ID": "IPR002048", "InterPro-Name": "EF_hand_dom", "InterPro-Type": "DOMAIN", "Beg": 77, "End": 112 } ], "response#1": "MAAFADRPTCRVSLGAVFLARELHRLRKSLPLCVFSLFLFSFAFSALSGAPSQFAEAAMPKLSGEKLAELMQMDVKDIKERMLALFDLIDTNQDNTIDTEEAKEWSAKLKNAMHQHQVRMEFQAIDKDNDGKVSLSELEATYVDSLDQKQLEQHKKEVEQRFKTVDKDNDGLLDLSEIRILMDPGKDEGLMKIEIEEILNAQDKNGDRKITVTEFIETEGTGSLNDVEKTELEKEFKSYDLNADGAIDVEELQQIIKDPHSHEIRMLLEEFTKDLKDGKVGREQWEKEFESFAVSMLTDNGEVLRFPEDYSGIEFPFKTAVPQVDVDDEDKHDEL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more EF_hand_dom, EF_hand_dom, EF_hand_dom, EF_hand_dom, EF_hand_dom, EF_hand_dom, EF_hand_dom, EF_hand_dom, EF_hand_dom, EF_hand_dom, EF_hand_dom, EF_hand_dom that are essential for its biological function; 2. The protein should be classified within EF-hand-dom_pair, EF-hand-dom_pair sharing conserved structural features; 3. The protein should include a EF_Hand_1_Ca_BS, EF_Hand_1_Ca_BS, EF_Hand_1_Ca_BS, EF_Hand_1_Ca_BS that enables ligand binding under diverse conditions. The designed protein sequence is ", "reference": "MAAFADRPTCRVSLGAVFLARELHRLRKSLPLCVFSLFLFSFAFSALSGAPSQFAEAAMPKLSGEKLAELMQMDVKDIKERMLALFDLIDTNQDNTIDTEEAKEWSAKLKNAMHQHQVRMEFQAIDKDNDGKVSLSELEATYVDSLDQKQLEQHKKEVEQRFKTVDKDNDGLLDLSEIRILMDPGKDEGLMKIEIEEILNAQDKNGDRKITVTEFIETEGTGSLNDVEKTELEKEFKSYDLNADGAIDVEELQQIIKDPHSHEIRMLLEEFTKDLKDGKVGREQWEKEFESFAVSMLTDNGEVLRFPEDYSGIEFPFKTAVPQVDVDDEDKHDEL" }, { "InterPro": [ { "InterPro-ID": "IPR036383", "InterPro-Name": "TSP1_rpt_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 637, "End": 703 }, { "InterPro-ID": "IPR000884", "InterPro-Name": "TSP1_rpt", "InterPro-Type": "REPEAT", "Beg": 642, "End": 677 }, { "InterPro-ID": "IPR000884", "InterPro-Name": "TSP1_rpt", "InterPro-Type": "REPEAT", "Beg": 641, "End": 704 }, { "InterPro-ID": "IPR000884", "InterPro-Name": "TSP1_rpt", "InterPro-Type": "REPEAT", "Beg": 638, "End": 704 }, { "InterPro-ID": "IPR036383", "InterPro-Name": "TSP1_rpt_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 616, "End": 709 } ], "response#1": "MMPATRRSASVLVSARGSAARFPASSVSFLHKGAADVCRRFSASLSPFSCSAFVSPSCPMASSSPFSPPLFSSLVSSPSSPSAGFPRSASSSASSAPPCSSAGVSKVSCLKLSCGERQQEGEPSLPRSAEERKATNRRELECLRALQSAVAEREAEADGGWTTWRGVSQRTWKQKRPALLSSRVTAAMSLEEEDSTSGPRGYEEERERRSGVCGERGQNGGEKLGRVQGVSTGDSESRTRCRRGLHFSPQTNRSFVVLLSCLLFFLVGEVQEVCLPSLQRMESSTDFFFFKIASAEAHTANPGDSSKSRRRSPRSSRFTSKASSDSSSSSRSSADSSSSSRSSADSSSSSRSSADSSSSHPSSSSSSPLSSSPDSSPEEVNGLRGRARVWTRRGGLSSRLREFLSDASALRSQESAADAVEEARARVRLLSRFARSRRQTLEALGGKSRRSEWRRKRTGMMASEARESHRGRDLNTLADREKKALKSALLAAQLSRRRMQSIQSERSLYSLVRPLLDESDAAGVYTANECVAVRYADYPKEFPGYDISTESCRCPDGWLPCAESDAVARMSAWEPVIWEENADEGCTSERGEVMLEHMNFYSCPQRTFVEYTGPRDATIRDKQCKRVAFVLCRAATSSCITGPWSEWTSCSVPCGEGYQYRWRIPVTGASSSTDKGAVTQRSSREACAPYHMEERRKCNLGACPEKITKTTCFWTTVQVDRAEGAFDEDQGSCKCGTGDDAIDREEGAMVPCTPEEAVASMDNWKSHFRQHCYTSLGLRRRSNLALRFHSYGHVVRLGLRDLWHLDCTGGWSKFNIFEAKMFCGVGAKILCRSRTDSAQVPFSMEQHNAESDAVTRISMLLKRQRRVEEASPQAFAEESLLLSEGGVSHLWISLCAGAVAAVVFLVCLTKRAAVGTFLRSRVSTATAGGETVSAKGSTRGSRNAGRRVFSAQAVREAVEERVHAFVAFARRQTTAVILATEKWMETAAEREVTQEMQGVSTASLRLLERDCKEREERDSARKSCPQEAKGLLEGEEDVPALLVFPALKTATDRVVRVARSTLSLETRSFSGAQRSAQRLWGKVRSIFLARGKEKRDEDLFYGEEGERGRIQRGGPAAFVSSLACQKVERRRARRGRREGDSGEGGDCGEARKANSGVAGRLDSLTEMERDDSFVLSAVEEKLLFPRGKRNTQEKLARINKAARTAAVSAVTPESFGSM", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should be classified within TSP1_rpt_sf, TSP1_rpt_sf sharing conserved structural features; 2. The protein should include one or more TSP1_rpt, TSP1_rpt, TSP1_rpt that provide structural or functional support. The designed protein sequence is ", "reference": "MMPATRRSASVLVSARGSAARFPASSVSFLHKGAADVCRRFSASLSPFSCSAFVSPSCPMASSSPFSPPLFSSLVSSPSSPSAGFPRSASSSASSAPPCSSAGVSKVSCLKLSCGERQQEGEPSLPRSAEERKATNRRELECLRALQSAVAEREAEADGGWTTWRGVSQRTWKQKRPALLSSRVTAAMSLEEEDSTSGPRGYEEERERRSGVCGERGQNGGEKLGRVQGVSTGDSESRTRCRRGLHFSPQTNRSFVVLLSCLLFFLVGEVQEVCLPSLQRMESSTDFFFFKIASAEAHTANPGDSSKSRRRSPRSSRFTSKASSDSSSSSRSSADSSSSSRSSADSSSSSRSSADSSSSHPSSSSSSPLSSSPDSSPEEVNGLRGRARVWTRRGGLSSRLREFLSDASALRSQESAADAVEEARARVRLLSRFARSRRQTLEALGGKSRRSEWRRKRTGMMASEARESHRGRDLNTLADREKKALKSALLAAQLSRRRMQSIQSERSLYSLVRPLLDESDAAGVYTANECVAVRYADYPKEFPGYDISTESCRCPDGWLPCAESDAVARMSAWEPVIWEENADEGCTSERGEVMLEHMNFYSCPQRTFVEYTGPRDATIRDKQCKRVAFVLCRAATSSCITGPWSEWTSCSVPCGEGYQYRWRIPVTGASSSTDKGAVTQRSSREACAPYHMEERRKCNLGACPEKITKTTCFWTTVQVDRAEGAFDEDQGSCKCGTGDDAIDREEGAMVPCTPEEAVASMDNWKSHFRQHCYTSLGLRRRSNLALRFHSYGHVVRLGLRDLWHLDCTGGWSKFNIFEAKMFCGVGAKILCRSRTDSAQVPFSMEQHNAESDAVTRISMLLKRQRRVEEASPQAFAEESLLLSEGGVSHLWISLCAGAVAAVVFLVCLTKRAAVGTFLRSRVSTATAGGETVSAKGSTRGSRNAGRRVFSAQAVREAVEERVHAFVAFARRQTTAVILATEKWMETAAEREVTQEMQGVSTASLRLLERDCKEREERDSARKSCPQEAKGLLEGEEDVPALLVFPALKTATDRVVRVARSTLSLETRSFSGAQRSAQRLWGKVRSIFLARGKEKRDEDLFYGEEGERGRIQRGGPAAFVSSLACQKVERRRARRGRREGDSGEGGDCGEARKANSGVAGRLDSLTEMERDDSFVLSAVEEKLLFPRGKRNTQEKLARINKAARTAAVSAVTPESFGSM" }, { "InterPro": [ { "InterPro-ID": "IPR032675", "InterPro-Name": "LRR_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 47, "End": 460 }, { "InterPro-ID": "IPR006553", "InterPro-Name": "Leu-rich_rpt_Cys-con_subtyp", "InterPro-Type": "REPEAT", "Beg": 382, "End": 407 }, { "InterPro-ID": "IPR006553", "InterPro-Name": "Leu-rich_rpt_Cys-con_subtyp", "InterPro-Type": "REPEAT", "Beg": 223, "End": 254 }, { "InterPro-ID": "IPR006553", "InterPro-Name": "Leu-rich_rpt_Cys-con_subtyp", "InterPro-Type": "REPEAT", "Beg": 356, "End": 381 }, { "InterPro-ID": "IPR041567", "InterPro-Name": "COI1_F-box", "InterPro-Type": "DOMAIN", "Beg": 14, "End": 51 } ], "response#1": "MAKTPIPFTTLNDLPDVILSNIIAAVSDTRSRNATALVCHKWLVLERSTRTSLTLRGNIRDLFMLPTCFRSITYLDLSLISPWGHPLLASRATDAPDNDSALIAHLLRHTFPSVTSLTLYARDPNTIQFLPAQWAHTLKHIKLVRWHQRAQLASGDELNLLFIGTPQITSLDLSNFYCWTDDVPPALQSNPNVACNLTRFNLLNASFPEGFKTDEIKVITKCCPNLKEFKVACMFDPRYIGFIGDEALVCLATNCPKLSVLHLADTSVLSNCRGDPNDEGFTVEDAQFSVSTLIEVFSGLSLLEELVFDVCNNVRDSGPALEILKTKCPKLRSLKLGQFHGISMPIESKLDGVALCQGLLSLSIRSVGDLDDMGLIGIGRGCSRLTKFEIECCKKITMRGMRTLASLLRKSLVDVTISCCKNLGASSSLKALEPIQDRIQRLHIDCVWDTVEEFENLDGVEYGFDLNEASGGEASSNPAGFGDTFGSMDDDLMNNRNKRCKYSYDLNSVYVENNGHGNGFCGRTWDRLQYLSLWIGVGELLTPLAAAGLQDCPKLEEIKIKVEGDCRLWSKPSERAFGLSTLIQYPKLVKMHLDCGDIIGYAHTAPSGQMDLSLWERFYLMGIRHLNLRELDYWPPQDRDVNQRSLSLPAAGLLQECVTLRKLFIHGTAHEHFMMFLLRIPNLRDVQLREDYYPAPENDMSTEMRADSLSRFEVALNRRQICD", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more COI1_F-box that are essential for its biological function; 2. The protein should be classified within LRR_dom_sf sharing conserved structural features; 3. The protein should include one or more Leu-rich_rpt_Cys-con_subtyp, Leu-rich_rpt_Cys-con_subtyp, Leu-rich_rpt_Cys-con_subtyp that provide structural or functional support. The designed protein sequence is ", "reference": "MAKTPIPFTTLNDLPDVILSNIIAAVSDTRSRNATALVCHKWLVLERSTRTSLTLRGNIRDLFMLPTCFRSITYLDLSLISPWGHPLLASRATDAPDNDSALIAHLLRHTFPSVTSLTLYARDPNTIQFLPAQWAHTLKHIKLVRWHQRAQLASGDELNLLFIGTPQITSLDLSNFYCWTDDVPPALQSNPNVACNLTRFNLLNASFPEGFKTDEIKVITKCCPNLKEFKVACMFDPRYIGFIGDEALVCLATNCPKLSVLHLADTSVLSNCRGDPNDEGFTVEDAQFSVSTLIEVFSGLSLLEELVFDVCNNVRDSGPALEILKTKCPKLRSLKLGQFHGISMPIESKLDGVALCQGLLSLSIRSVGDLDDMGLIGIGRGCSRLTKFEIECCKKITMRGMRTLASLLRKSLVDVTISCCKNLGASSSLKALEPIQDRIQRLHIDCVWDTVEEFENLDGVEYGFDLNEASGGEASSNPAGFGDTFGSMDDDLMNNRNKRCKYSYDLNSVYVENNGHGNGFCGRTWDRLQYLSLWIGVGELLTPLAAAGLQDCPKLEEIKIKVEGDCRLWSKPSERAFGLSTLIQYPKLVKMHLDCGDIIGYAHTAPSGQMDLSLWERFYLMGIRHLNLRELDYWPPQDRDVNQRSLSLPAAGLLQECVTLRKLFIHGTAHEHFMMFLLRIPNLRDVQLREDYYPAPENDMSTEMRADSLSRFEVALNRRQICD" }, { "InterPro": [ { "InterPro-ID": "IPR006212", "InterPro-Name": "Furin_repeat", "InterPro-Type": "REPEAT", "Beg": 540, "End": 573 }, { "InterPro-ID": "IPR009030", "InterPro-Name": "Growth_fac_rcpt_cys_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 776, "End": 910 }, { "InterPro-ID": "IPR006212", "InterPro-Name": "Furin_repeat", "InterPro-Type": "REPEAT", "Beg": 955, "End": 1003 }, { "InterPro-ID": "IPR009030", "InterPro-Name": "Growth_fac_rcpt_cys_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 443, "End": 552 }, { "InterPro-ID": "IPR006212", "InterPro-Name": "Furin_repeat", "InterPro-Type": "REPEAT", "Beg": 1069, "End": 1117 }, { "InterPro-ID": "IPR000742", "InterPro-Name": "EGF-like_dom", "InterPro-Type": "DOMAIN", "Beg": 1351, "End": 1383 }, { "InterPro-ID": "IPR000742", "InterPro-Name": "EGF-like_dom", "InterPro-Type": "DOMAIN", "Beg": 1742, "End": 1773 }, { "InterPro-ID": "IPR000742", "InterPro-Name": "EGF-like_dom", "InterPro-Type": "DOMAIN", "Beg": 537, "End": 571 }, { "InterPro-ID": "IPR000742", "InterPro-Name": "EGF-like_dom", "InterPro-Type": "DOMAIN", "Beg": 703, "End": 732 }, { "InterPro-ID": "IPR000742", "InterPro-Name": "EGF-like_dom", "InterPro-Type": "DOMAIN", "Beg": 955, "End": 988 }, { "InterPro-ID": "IPR000742", "InterPro-Name": "EGF-like_dom", "InterPro-Type": "DOMAIN", "Beg": 1159, "End": 1201 }, { "InterPro-ID": "IPR000742", "InterPro-Name": "EGF-like_dom", "InterPro-Type": "DOMAIN", "Beg": 824, "End": 859 }, { "InterPro-ID": "IPR000742", "InterPro-Name": "EGF-like_dom", "InterPro-Type": "DOMAIN", "Beg": 619, "End": 649 }, { "InterPro-ID": "IPR000742", "InterPro-Name": "EGF-like_dom", "InterPro-Type": "DOMAIN", "Beg": 572, "End": 602 }, { "InterPro-ID": "IPR000742", "InterPro-Name": "EGF-like_dom", "InterPro-Type": "DOMAIN", "Beg": 909, "End": 938 }, { "InterPro-ID": "IPR000742", "InterPro-Name": "EGF-like_dom", "InterPro-Type": "DOMAIN", "Beg": 1239, "End": 1270 }, { "InterPro-ID": "IPR000742", "InterPro-Name": "EGF-like_dom", "InterPro-Type": "DOMAIN", "Beg": 733, "End": 763 }, { "InterPro-ID": "IPR000742", "InterPro-Name": "EGF-like_dom", "InterPro-Type": "DOMAIN", "Beg": 1038, "End": 1067 }, { "InterPro-ID": "IPR000742", "InterPro-Name": "EGF-like_dom", "InterPro-Type": "DOMAIN", "Beg": 1286, "End": 1323 }, { "InterPro-ID": "IPR000742", "InterPro-Name": "EGF-like_dom", "InterPro-Type": "DOMAIN", "Beg": 1118, "End": 1151 }, { "InterPro-ID": "IPR006212", "InterPro-Name": "Furin_repeat", "InterPro-Type": "REPEAT", "Beg": 651, "End": 702 }, { "InterPro-ID": "IPR000742", "InterPro-Name": "EGF-like_dom", "InterPro-Type": "DOMAIN", "Beg": 1761, "End": 1772 }, { "InterPro-ID": "IPR000742", "InterPro-Name": "EGF-like_dom", "InterPro-Type": "DOMAIN", "Beg": 1739, "End": 1773 }, { "InterPro-ID": "IPR009030", "InterPro-Name": "Growth_fac_rcpt_cys_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 534, "End": 648 }, { "InterPro-ID": "IPR009030", "InterPro-Name": "Growth_fac_rcpt_cys_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1197, "End": 1360 }, { "InterPro-ID": "IPR009030", "InterPro-Name": "Growth_fac_rcpt_cys_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1113, "End": 1249 }, { "InterPro-ID": "IPR009030", "InterPro-Name": "Growth_fac_rcpt_cys_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1044, "End": 1131 }, { "InterPro-ID": "IPR006212", "InterPro-Name": "Furin_repeat", "InterPro-Type": "REPEAT", "Beg": 950, "End": 983 }, { "InterPro-ID": "IPR006212", "InterPro-Name": "Furin_repeat", "InterPro-Type": "REPEAT", "Beg": 984, "End": 1027 }, { "InterPro-ID": "IPR006212", "InterPro-Name": "Furin_repeat", "InterPro-Type": "REPEAT", "Beg": 1113, "End": 1144 }, { "InterPro-ID": "IPR006212", "InterPro-Name": "Furin_repeat", "InterPro-Type": "REPEAT", "Beg": 431, "End": 481 }, { "InterPro-ID": "IPR006212", "InterPro-Name": "Furin_repeat", "InterPro-Type": "REPEAT", "Beg": 1346, "End": 1394 }, { "InterPro-ID": "IPR006212", "InterPro-Name": "Furin_repeat", "InterPro-Type": "REPEAT", "Beg": 1281, "End": 1332 }, { "InterPro-ID": "IPR006212", "InterPro-Name": "Furin_repeat", "InterPro-Type": "REPEAT", "Beg": 775, "End": 813 }, { "InterPro-ID": "IPR006212", "InterPro-Name": "Furin_repeat", "InterPro-Type": "REPEAT", "Beg": 904, "End": 947 }, { "InterPro-ID": "IPR006212", "InterPro-Name": "Furin_repeat", "InterPro-Type": "REPEAT", "Beg": 645, "End": 694 }, { "InterPro-ID": "IPR006212", "InterPro-Name": "Furin_repeat", "InterPro-Type": "REPEAT", "Beg": 1197, "End": 1232 }, { "InterPro-ID": "IPR006212", "InterPro-Name": "Furin_repeat", "InterPro-Type": "REPEAT", "Beg": 819, "End": 868 }, { "InterPro-ID": "IPR006212", "InterPro-Name": "Furin_repeat", "InterPro-Type": "REPEAT", "Beg": 485, "End": 530 }, { "InterPro-ID": "IPR006212", "InterPro-Name": "Furin_repeat", "InterPro-Type": "REPEAT", "Beg": 1402, "End": 1436 }, { "InterPro-ID": "IPR006212", "InterPro-Name": "Furin_repeat", "InterPro-Type": "REPEAT", "Beg": 567, "End": 611 }, { "InterPro-ID": "IPR006212", "InterPro-Name": "Furin_repeat", "InterPro-Type": "REPEAT", "Beg": 1147, "End": 1193 }, { "InterPro-ID": "IPR006212", "InterPro-Name": "Furin_repeat", "InterPro-Type": "REPEAT", "Beg": 698, "End": 727 }, { "InterPro-ID": "IPR006212", "InterPro-Name": "Furin_repeat", "InterPro-Type": "REPEAT", "Beg": 728, "End": 772 }, { "InterPro-ID": "IPR006212", "InterPro-Name": "Furin_repeat", "InterPro-Type": "REPEAT", "Beg": 1063, "End": 1109 }, { "InterPro-ID": "IPR006212", "InterPro-Name": "Furin_repeat", "InterPro-Type": "REPEAT", "Beg": 1234, "End": 1279 }, { "InterPro-ID": "IPR006212", "InterPro-Name": "Furin_repeat", "InterPro-Type": "REPEAT", "Beg": 535, "End": 566 }, { "InterPro-ID": "IPR009030", "InterPro-Name": "Growth_fac_rcpt_cys_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 648, "End": 779 }, { "InterPro-ID": "IPR006212", "InterPro-Name": "Furin_repeat", "InterPro-Type": "REPEAT", "Beg": 1240, "End": 1277 }, { "InterPro-ID": "IPR006212", "InterPro-Name": "Furin_repeat", "InterPro-Type": "REPEAT", "Beg": 1153, "End": 1201 }, { "InterPro-ID": "IPR006212", "InterPro-Name": "Furin_repeat", "InterPro-Type": "REPEAT", "Beg": 491, "End": 539 }, { "InterPro-ID": "IPR009030", "InterPro-Name": "Growth_fac_rcpt_cys_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 906, "End": 1041 }, { "InterPro-ID": "IPR009030", "InterPro-Name": "Growth_fac_rcpt_cys_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1345, "End": 1444 } ], "response#1": "MKIFIKDKTSTNLLNIFALYFSAICFIYCQNSCQPQNLKTDTNSQSLNLSSSTQMFMLYGWVSSTQQTSYNIYKIKDSVNDPVLSLDFNYSNQILTISGKNIQNIYQQNSLWFFFLTQIDQNGQQLTVYFSQPQIQRDYYNKFNLASQLTLQSSGQITLSISAANYKNLQFINGANFASSGYQNAQSFMFQDFQGYLYSFKLDQVYERSLLKEDVQQRMYPIYPTIDGQLNSATYSKAYQGIQLINQNITLSNGQFMRYYSTFQIQNVILTDPFFLGFYFRLTNLTQDDNNIFYIVSEGLQNPESISFVMIQNSLKIKMIDKQYLLYSNNLFTNQWYYLSLTWASIQVDSTQKFQSQIMVSIRQQYSQSAYKQLVQLAYPLSVQSTTYSIYFGYVPSQYNSQSTNYGIYGYISKILIGQGGSLISNTDEFKNTCKIQNQCDVLFLGSQGTSCQVCSSGYLNLSSMDSNTCIYTTCPSGYYFSNEFMQCQQCNQACLTCFSAGNDSCPQCLNGYYQYQQTCFKKCPDGFYISDQANFKCEKCNASCLSCTGPSFDQCLSCKSGFYLSSNTCQPCSQTCSQCTDMSTCQSCINGYYLDSNNSCISSCPNGQFANVQNQCQNCSIPNCYLCSSLTSCTQCNDKFYLSNNQCQSCDPTCTKCFGPTNQQCFACIQNKYLYNSACLSQSDCTALVGYFPNFQTSVCQACQGKCKTCTSSNTCSSCINGYYLQDSNCLPCPPQCSSCQSSTVCTSCYQNYYLDGNNNCSLTCPDGTFGNSQNICQTCIDGCQTCYGPTLLECYSCEQGFFFQAFQITNNSQAIQKGMCIACSQFCLSCTSRYYCTACKPLRFMKILPNLNQQLCVDDCGSYYLSDETDYTCKSCQSGCQTCSITVSNCQTCIQGYYNSGGRVCNQCLSKCLQCSQIGICTSCASGFYLQNNSCQNACLSGFPDSSQNVCVACHPTCVTCQGPLATDCLTCISGYYLNPANNICQICDPGCYSCSSKTNCSQCNNNYFLYSNYCYLACPSRTYPTQVNGISVCLPCTDPACLQCSNLQCITCMAGYFINQGACQVCDSSCNTCMNSPKICTSCDQTKKLVLSNTQCVSQCASNQYVDSVQNRCLPCFYSCSSCFGPNSNQCFSCQPNGFYLTNQTQCSICDISCLQCSGPGFDSCIQCAQGYYKLGDSVCVQSCPDGFFLNTSNNQCQSCNQVCFNCNGPQNSDCTSCAAGYYQSISNQNGIICSQCNSKCLTCNGPFSSNCILCNSGYVKYNSQCQTFCPQGYRSIKGVCIQCPSNCGYCVNQSLNSNSQVCTQCLQNYILNQLDNTCVQVCPNGTFQVFIASNQQAPDISSYYCQSCDQGCLSCSQSSSNCTQCKTGYIFHETVNQCVYGGTCLNGFILYIDSQTQNQYCKVCKINCVSCIQQFFYYQENCYSSCPVGTVQVSQSNICVLNLLPQLTILTNPAQVTFKEDVTIVTQIQSPIQITSMVWSLISPSPTSDLGSKFLQNLILNNITNLYIPLSNISPLSLYQIQFTIANSKGSATQTISLNTQLMLTPGTVNCQPSSNIFSGTTQIQLTLLNFIHPSPLFYDYILSPISNTYSFQRINNMTATNQDLLSLDNFFVVFITTNSKQLNLTTYQVRQQQSINVVVNVFNQYVFYQTSSQVQFLKGSAFTYNTTDINSDLTKFDTLVASMIANTNQLTQLSTFIQDIRTLKEVLYNYLQNAYSQSQQQIYLQKSFFQVINSDISCSLNLCMNSGKCVPNSIFCSCPSAFTGPKCQIDVKRSQQLSQYLEGALSLIYQNMASNISNDGLVNILMDISFFRDMLDKAIYPVYFQILSKYFSQKLTTVITNNGNVSFLSSKTLSYCFIQIFENLNPIIINYNSTQLPDKSTFLQLLTNIKDLSIITIITSQNSPLNVASPYYFYASIGVITSSMFPQILDQYQNYYNTSNSASFSSSLLMRNLQLQEQTSQQTDPSQNNVNVGQEFGTGIDLLKSLFNFPVIEYQSNRHFIYLPQSTITSFSNLRIVVAEIFDIASALPYSSQLLSQQFLLATGFFTVIISQSQQIIPIINNPNPITIIIPKMVSYPSLNYVDPKLPVYNCLHYDQNKDQFETNSCFFQRENSTHIACSCYTIKSYITVQINKQNIQSLPVYNDIILSNNFTFDSYVTEKLRVYKEVNKFTDANTTFSVEQEKFQELMILKNYYGLYIMIIISLGIGAAFLGYSAIKSKYLDEKINMKDHSRIYFLYYFPIISFLVGPTNQFVNNYTRAVTSLTIIASHFAFSSIYVQILPFDMQSSTQQILTSIITVSSTSVCIYWTIGVYHMIVVGLNNNLNEEKNTGSTWKIVEGFKYSFGVTMIGLVLAVLALISISVFIGLCDDDQFNIWQDIIKAVFLIDLIADAIVVFILIIVGYDSTIGSFFALRGYGITIQSDNKVKHQKLDKEVKLDEKKNTK", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more EGF-like_dom, EGF-like_dom, EGF-like_dom, EGF-like_dom, EGF-like_dom, EGF-like_dom, EGF-like_dom, EGF-like_dom, EGF-like_dom, EGF-like_dom, EGF-like_dom, EGF-like_dom, EGF-like_dom, EGF-like_dom, EGF-like_dom, EGF-like_dom, EGF-like_dom that are essential for its biological function; 2. The protein should be classified within Growth_fac_rcpt_cys_sf, Growth_fac_rcpt_cys_sf, Growth_fac_rcpt_cys_sf, Growth_fac_rcpt_cys_sf, Growth_fac_rcpt_cys_sf, Growth_fac_rcpt_cys_sf, Growth_fac_rcpt_cys_sf, Growth_fac_rcpt_cys_sf, Growth_fac_rcpt_cys_sf sharing conserved structural features; 3. The protein should include one or more Furin_repeat, Furin_repeat, Furin_repeat, Furin_repeat, Furin_repeat, Furin_repeat, Furin_repeat, Furin_repeat, Furin_repeat, Furin_repeat, Furin_repeat, Furin_repeat, Furin_repeat, Furin_repeat, Furin_repeat, Furin_repeat, Furin_repeat, Furin_repeat, Furin_repeat, Furin_repeat, Furin_repeat, Furin_repeat, Furin_repeat, Furin_repeat, Furin_repeat, Furin_repeat, Furin_repeat that provide structural or functional support. The designed protein sequence is ", "reference": "MKIFIKDKTSTNLLNIFALYFSAICFIYCQNSCQPQNLKTDTNSQSLNLSSSTQMFMLYGWVSSTQQTSYNIYKIKDSVNDPVLSLDFNYSNQILTISGKNIQNIYQQNSLWFFFLTQIDQNGQQLTVYFSQPQIQRDYYNKFNLASQLTLQSSGQITLSISAANYKNLQFINGANFASSGYQNAQSFMFQDFQGYLYSFKLDQVYERSLLKEDVQQRMYPIYPTIDGQLNSATYSKAYQGIQLINQNITLSNGQFMRYYSTFQIQNVILTDPFFLGFYFRLTNLTQDDNNIFYIVSEGLQNPESISFVMIQNSLKIKMIDKQYLLYSNNLFTNQWYYLSLTWASIQVDSTQKFQSQIMVSIRQQYSQSAYKQLVQLAYPLSVQSTTYSIYFGYVPSQYNSQSTNYGIYGYISKILIGQGGSLISNTDEFKNTCKIQNQCDVLFLGSQGTSCQVCSSGYLNLSSMDSNTCIYTTCPSGYYFSNEFMQCQQCNQACLTCFSAGNDSCPQCLNGYYQYQQTCFKKCPDGFYISDQANFKCEKCNASCLSCTGPSFDQCLSCKSGFYLSSNTCQPCSQTCSQCTDMSTCQSCINGYYLDSNNSCISSCPNGQFANVQNQCQNCSIPNCYLCSSLTSCTQCNDKFYLSNNQCQSCDPTCTKCFGPTNQQCFACIQNKYLYNSACLSQSDCTALVGYFPNFQTSVCQACQGKCKTCTSSNTCSSCINGYYLQDSNCLPCPPQCSSCQSSTVCTSCYQNYYLDGNNNCSLTCPDGTFGNSQNICQTCIDGCQTCYGPTLLECYSCEQGFFFQAFQITNNSQAIQKGMCIACSQFCLSCTSRYYCTACKPLRFMKILPNLNQQLCVDDCGSYYLSDETDYTCKSCQSGCQTCSITVSNCQTCIQGYYNSGGRVCNQCLSKCLQCSQIGICTSCASGFYLQNNSCQNACLSGFPDSSQNVCVACHPTCVTCQGPLATDCLTCISGYYLNPANNICQICDPGCYSCSSKTNCSQCNNNYFLYSNYCYLACPSRTYPTQVNGISVCLPCTDPACLQCSNLQCITCMAGYFINQGACQVCDSSCNTCMNSPKICTSCDQTKKLVLSNTQCVSQCASNQYVDSVQNRCLPCFYSCSSCFGPNSNQCFSCQPNGFYLTNQTQCSICDISCLQCSGPGFDSCIQCAQGYYKLGDSVCVQSCPDGFFLNTSNNQCQSCNQVCFNCNGPQNSDCTSCAAGYYQSISNQNGIICSQCNSKCLTCNGPFSSNCILCNSGYVKYNSQCQTFCPQGYRSIKGVCIQCPSNCGYCVNQSLNSNSQVCTQCLQNYILNQLDNTCVQVCPNGTFQVFIASNQQAPDISSYYCQSCDQGCLSCSQSSSNCTQCKTGYIFHETVNQCVYGGTCLNGFILYIDSQTQNQYCKVCKINCVSCIQQFFYYQENCYSSCPVGTVQVSQSNICVLNLLPQLTILTNPAQVTFKEDVTIVTQIQSPIQITSMVWSLISPSPTSDLGSKFLQNLILNNITNLYIPLSNISPLSLYQIQFTIANSKGSATQTISLNTQLMLTPGTVNCQPSSNIFSGTTQIQLTLLNFIHPSPLFYDYILSPISNTYSFQRINNMTATNQDLLSLDNFFVVFITTNSKQLNLTTYQVRQQQSINVVVNVFNQYVFYQTSSQVQFLKGSAFTYNTTDINSDLTKFDTLVASMIANTNQLTQLSTFIQDIRTLKEVLYNYLQNAYSQSQQQIYLQKSFFQVINSDISCSLNLCMNSGKCVPNSIFCSCPSAFTGPKCQIDVKRSQQLSQYLEGALSLIYQNMASNISNDGLVNILMDISFFRDMLDKAIYPVYFQILSKYFSQKLTTVITNNGNVSFLSSKTLSYCFIQIFENLNPIIINYNSTQLPDKSTFLQLLTNIKDLSIITIITSQNSPLNVASPYYFYASIGVITSSMFPQILDQYQNYYNTSNSASFSSSLLMRNLQLQEQTSQQTDPSQNNVNVGQEFGTGIDLLKSLFNFPVIEYQSNRHFIYLPQSTITSFSNLRIVVAEIFDIASALPYSSQLLSQQFLLATGFFTVIISQSQQIIPIINNPNPITIIIPKMVSYPSLNYVDPKLPVYNCLHYDQNKDQFETNSCFFQRENSTHIACSCYTIKSYITVQINKQNIQSLPVYNDIILSNNFTFDSYVTEKLRVYKEVNKFTDANTTFSVEQEKFQELMILKNYYGLYIMIIISLGIGAAFLGYSAIKSKYLDEKINMKDHSRIYFLYYFPIISFLVGPTNQFVNNYTRAVTSLTIIASHFAFSSIYVQILPFDMQSSTQQILTSIITVSSTSVCIYWTIGVYHMIVVGLNNNLNEEKNTGSTWKIVEGFKYSFGVTMIGLVLAVLALISISVFIGLCDDDQFNIWQDIIKAVFLIDLIADAIVVFILIIVGYDSTIGSFFALRGYGITIQSDNKVKHQKLDKEVKLDEKKNTK" }, { "InterPro": [ { "InterPro-ID": "IPR050117", "InterPro-Name": "MAP_kinase", "InterPro-Type": "FAMILY", "Beg": 18, "End": 307 }, { "InterPro-ID": "IPR011009", "InterPro-Name": "Kinase-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 5, "End": 338 }, { "InterPro-ID": "IPR008271", "InterPro-Name": "Ser/Thr_kinase_AS", "InterPro-Type": "ACTIVE_SITE", "Beg": 137, "End": 149 }, { "InterPro-ID": "IPR000719", "InterPro-Name": "Prot_kinase_dom", "InterPro-Type": "DOMAIN", "Beg": 20, "End": 299 }, { "InterPro-ID": "IPR017441", "InterPro-Name": "Protein_kinase_ATP_BS", "InterPro-Type": "BINDING_SITE", "Beg": 26, "End": 50 }, { "InterPro-ID": "IPR038783", "InterPro-Name": "MAPK_Sty1/Hog1", "InterPro-Type": "FAMILY", "Beg": 9, "End": 336 }, { "InterPro-ID": "IPR003527", "InterPro-Name": "MAP_kinase_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 55, "End": 153 }, { "InterPro-ID": "IPR008352", "InterPro-Name": "MAPK_p38-like", "InterPro-Type": "FAMILY", "Beg": 261, "End": 274 }, { "InterPro-ID": "IPR008352", "InterPro-Name": "MAPK_p38-like", "InterPro-Type": "FAMILY", "Beg": 277, "End": 285 }, { "InterPro-ID": "IPR008352", "InterPro-Name": "MAPK_p38-like", "InterPro-Type": "FAMILY", "Beg": 184, "End": 194 }, { "InterPro-ID": "IPR008352", "InterPro-Name": "MAPK_p38-like", "InterPro-Type": "FAMILY", "Beg": 298, "End": 308 } ], "response#1": "MAEFVRAQIFGTTFEITSRYTELAPVGMGAFGLVCSAKDQLTNQAVAVKKIMKPFSTPVLSKRTYRELKLLKHLRHENVISLSDIFISPLEDIYFVTELLGTDLHRLLTSRPLEKQFIQYFLYQILRGLKYVHSAGVVHRDLKPSNILVNENCDLKICDFGLARIQDPQMTGYVSTRYYRAPEIMLTWQKYDVEVDIWSVGCIFAEMLEGKPLFPGKDHVNQFSIITELLGTPPDDVIQTICSENTLRFVQSLPKRERQPLTKKFKNADPQAIELLERMLVFDPRTRIRAGDALADPYLAPYHDPTDEPEAEEKFDWSFNDADLPVDTWKIMMYSEILDYHNVDAQNGEEVGVPQ", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Prot_kinase_dom that are essential for its biological function; 2. The protein should belong to MAP_kinase, MAPK_Sty1/Hog1, MAPK_p38-like, MAPK_p38-like, MAPK_p38-like, MAPK_p38-like that shares evolutionary origin and functional similarity; 3. The protein should be classified within Kinase-like_dom_sf sharing conserved structural features; 4. The protein should contain MAP_kinase_CS that is preserved across related proteins; 5. The protein must have Ser/Thr_kinase_AS that is conserved among related catalytic enzymes; 6. The protein should include a Protein_kinase_ATP_BS that enables ligand binding under diverse conditions. The designed protein sequence is ", "reference": "MAEFVRAQIFGTTFEITSRYTELAPVGMGAFGLVCSAKDQLTNQAVAVKKIMKPFSTPVLSKRTYRELKLLKHLRHENVISLSDIFISPLEDIYFVTELLGTDLHRLLTSRPLEKQFIQYFLYQILRGLKYVHSAGVVHRDLKPSNILVNENCDLKICDFGLARIQDPQMTGYVSTRYYRAPEIMLTWQKYDVEVDIWSVGCIFAEMLEGKPLFPGKDHVNQFSIITELLGTPPDDVIQTICSENTLRFVQSLPKRERQPLTKKFKNADPQAIELLERMLVFDPRTRIRAGDALADPYLAPYHDPTDEPEAEEKFDWSFNDADLPVDTWKIMMYSEILDYHNVDAQNGEEVGVPQ" }, { "InterPro": [ { "InterPro-ID": "IPR036259", "InterPro-Name": "MFS_trans_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 41, "End": 229 }, { "InterPro-ID": "IPR039309", "InterPro-Name": "BT1", "InterPro-Type": "FAMILY", "Beg": 43, "End": 444 }, { "InterPro-ID": "IPR039309", "InterPro-Name": "BT1", "InterPro-Type": "FAMILY", "Beg": 53, "End": 449 }, { "InterPro-ID": "IPR036259", "InterPro-Name": "MFS_trans_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 47, "End": 441 } ], "response#1": "MIEKSNNIYLSIDPIVERIKKNGEELPLINSEKKGIDYTQIVVYLVGLSDGLIHLASLAIYYLFKDHYRLTPYQVSLILMYPYLPFILKPIIALITDSISIFGMRRKPYLFLFSLFQSLNFLSLALVDLSLIQATLVLFFISLCASFCTTVAEALVVESSIGKTYSQGTNKVTEFIASKAVGSLSVAYFSGYFLEKVSREYIFMATSIFPLIISISCLFLKEKEYVTRKNIFKQMTDLIKFINTPVFIGPFLYIFVYMSGPDYDDAFFFFCTNKLGFRPSFMGTLRLTYGIASLIGIIVYRVFLKNSSLRNTLIFTTLVSFPIYISPIILTEKINKYFGISNELFVLSGGFLIEAITEIQLLPLFILTANICQEGLEASVFATILSVKNLGSLTKKGTSSLLTYLMKIDTYNFDNLSMYILTCGLFLLLSLSLVPLLPSEDQIESLKNKKIQK", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to BT1, BT1 that shares evolutionary origin and functional similarity; 2. The protein should be classified within MFS_trans_sf, MFS_trans_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MIEKSNNIYLSIDPIVERIKKNGEELPLINSEKKGIDYTQIVVYLVGLSDGLIHLASLAIYYLFKDHYRLTPYQVSLILMYPYLPFILKPIIALITDSISIFGMRRKPYLFLFSLFQSLNFLSLALVDLSLIQATLVLFFISLCASFCTTVAEALVVESSIGKTYSQGTNKVTEFIASKAVGSLSVAYFSGYFLEKVSREYIFMATSIFPLIISISCLFLKEKEYVTRKNIFKQMTDLIKFINTPVFIGPFLYIFVYMSGPDYDDAFFFFCTNKLGFRPSFMGTLRLTYGIASLIGIIVYRVFLKNSSLRNTLIFTTLVSFPIYISPIILTEKINKYFGISNELFVLSGGFLIEAITEIQLLPLFILTANICQEGLEASVFATILSVKNLGSLTKKGTSSLLTYLMKIDTYNFDNLSMYILTCGLFLLLSLSLVPLLPSEDQIESLKNKKIQK" }, { "InterPro": [ { "InterPro-ID": "IPR002259", "InterPro-Name": "Eqnu_transpt", "InterPro-Type": "FAMILY", "Beg": 151, "End": 488 }, { "InterPro-ID": "IPR002259", "InterPro-Name": "Eqnu_transpt", "InterPro-Type": "FAMILY", "Beg": 25, "End": 491 }, { "InterPro-ID": "IPR034764", "InterPro-Name": "ENT1/ENT2", "InterPro-Type": "FAMILY", "Beg": 33, "End": 494 }, { "InterPro-ID": "IPR036259", "InterPro-Name": "MFS_trans_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 333, "End": 487 }, { "InterPro-ID": "IPR002259", "InterPro-Name": "Eqnu_transpt", "InterPro-Type": "FAMILY", "Beg": 427, "End": 443 }, { "InterPro-ID": "IPR002259", "InterPro-Name": "Eqnu_transpt", "InterPro-Type": "FAMILY", "Beg": 177, "End": 197 }, { "InterPro-ID": "IPR002259", "InterPro-Name": "Eqnu_transpt", "InterPro-Type": "FAMILY", "Beg": 149, "End": 171 } ], "response#1": "MSSHTSTPNHASAAPPRKWYDMTSAEFYVYVVAFMCGISMLMPINAVFSAPSYMLQYYLYATKDPNHVPQMTNFWSNVMTYYNLIGLVTGLVMEPLTLLKSFRKIPMLVRLLGGLCILIVEIIVLMAVPARGTTEGGAVATMCIAGFIGGLGKSIFESTVYGMFGAFPPSFTSIMMGGVGISGVLTSLIQIIVKAALPDTYEGVKKQSYIYYSLDVGIQAATFIALIMMRFNSFAQLHFGDLGGVKSKVDAGSLAGAGENVREPGAEATELEQYTEPAIGQIQEKNAEAHKDDPLVDREHSDDVDEHGDALRAVEGPTSNEILRATSIISVLRSIKWMFVSCAFVFVVTLFLFPGIATGMFPESKWFATVAVFIFNCCDVLGRVAPALRFMWPRSYNQRWIIVAASFARVIFVPLLLLYSYHYIPSEAYGYVIMVIFGFSSGYVASMSLTLGPQSKGIDNDGKRFVAGTLMGISILVGGTIGTVLSIMTQTIREKY", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Eqnu_transpt, Eqnu_transpt, ENT1/ENT2, Eqnu_transpt, Eqnu_transpt, Eqnu_transpt that shares evolutionary origin and functional similarity; 2. The protein should be classified within MFS_trans_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MSSHTSTPNHASAAPPRKWYDMTSAEFYVYVVAFMCGISMLMPINAVFSAPSYMLQYYLYATKDPNHVPQMTNFWSNVMTYYNLIGLVTGLVMEPLTLLKSFRKIPMLVRLLGGLCILIVEIIVLMAVPARGTTEGGAVATMCIAGFIGGLGKSIFESTVYGMFGAFPPSFTSIMMGGVGISGVLTSLIQIIVKAALPDTYEGVKKQSYIYYSLDVGIQAATFIALIMMRFNSFAQLHFGDLGGVKSKVDAGSLAGAGENVREPGAEATELEQYTEPAIGQIQEKNAEAHKDDPLVDREHSDDVDEHGDALRAVEGPTSNEILRATSIISVLRSIKWMFVSCAFVFVVTLFLFPGIATGMFPESKWFATVAVFIFNCCDVLGRVAPALRFMWPRSYNQRWIIVAASFARVIFVPLLLLYSYHYIPSEAYGYVIMVIFGFSSGYVASMSLTLGPQSKGIDNDGKRFVAGTLMGISILVGGTIGTVLSIMTQTIREKY" }, { "InterPro": [ { "InterPro-ID": "IPR036052", "InterPro-Name": "TrpB-like_PALP_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 113, "End": 514 }, { "InterPro-ID": "IPR001926", "InterPro-Name": "TrpB-like_PALP", "InterPro-Type": "DOMAIN", "Beg": 97, "End": 349 }, { "InterPro-ID": "IPR037158", "InterPro-Name": "Thr_synth_N_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1, "End": 90 }, { "InterPro-ID": "IPR036052", "InterPro-Name": "TrpB-like_PALP_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 103, "End": 504 }, { "InterPro-ID": "IPR029144", "InterPro-Name": "Thr_synth_N", "InterPro-Type": "DOMAIN", "Beg": 6, "End": 85 }, { "InterPro-ID": "IPR036052", "InterPro-Name": "TrpB-like_PALP_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 3, "End": 519 }, { "InterPro-ID": "IPR000634", "InterPro-Name": "Ser/Thr_deHydtase_PyrdxlP-BS", "InterPro-Type": "BINDING_SITE", "Beg": 107, "End": 121 }, { "InterPro-ID": "IPR051166", "InterPro-Name": "Threonine_Synthase", "InterPro-Type": "FAMILY", "Beg": 5, "End": 538 }, { "InterPro-ID": "IPR004450", "InterPro-Name": "Thr_synthase-like", "InterPro-Type": "FAMILY", "Beg": 74, "End": 342 } ], "response#1": "MAQEMRYFSTRGGKETLSFEDAVLTGLAPNGGLYIPTHIPALPKDWKTKWAGLSFPELSHEILSLFVPTSVIPSDDLQSIINTAYSSFRSPATTPIRQTGDNEYVLELWHGPTWAFKDVALQFLGELFRYFLERRNKDKTEDMEELTVVGATSGDTGSAAIYGLRSKPSITIFILYPDGRVSPIQEAQMATVPDANVYCVAVEDSDFDTCQSIVKTLFSDAQFNATHRLGAINSINWARILAQIVYYFSAYFQLPEEARKDGAKLQFVVPTGNFGDILAGWYAKKLGLPMEQLVVATNENDILERFFRTGRYEADDAVQQDQTAETAAVNGSSDGQQAVSAVKATHSPAMDILLSSNFERLLYYLALETNGTEGSDEEKRFKAQERLNDWMSTLKKDGKVDLGEDVRQAAGKDFWAERVSDGQTLEEIQKYYRREKYGPYVVDPHTAVGLTAQERSAKKASPDTTWITLSTAHPAKFSGAVELALSASEFPDFDFRRDVLPDELKKLEGLEKRVHRVKGEEGVRALIEKVKSASHEKVDAEEGRGSL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more TrpB-like_PALP, Thr_synth_N that are essential for its biological function; 2. The protein should belong to Threonine_Synthase, Thr_synthase-like that shares evolutionary origin and functional similarity; 3. The protein should be classified within TrpB-like_PALP_sf, Thr_synth_N_sf, TrpB-like_PALP_sf, TrpB-like_PALP_sf sharing conserved structural features; 4. The protein should include a Ser/Thr_deHydtase_PyrdxlP-BS that enables ligand binding under diverse conditions. The designed protein sequence is ", "reference": "MAQEMRYFSTRGGKETLSFEDAVLTGLAPNGGLYIPTHIPALPKDWKTKWAGLSFPELSHEILSLFVPTSVIPSDDLQSIINTAYSSFRSPATTPIRQTGDNEYVLELWHGPTWAFKDVALQFLGELFRYFLERRNKDKTEDMEELTVVGATSGDTGSAAIYGLRSKPSITIFILYPDGRVSPIQEAQMATVPDANVYCVAVEDSDFDTCQSIVKTLFSDAQFNATHRLGAINSINWARILAQIVYYFSAYFQLPEEARKDGAKLQFVVPTGNFGDILAGWYAKKLGLPMEQLVVATNENDILERFFRTGRYEADDAVQQDQTAETAAVNGSSDGQQAVSAVKATHSPAMDILLSSNFERLLYYLALETNGTEGSDEEKRFKAQERLNDWMSTLKKDGKVDLGEDVRQAAGKDFWAERVSDGQTLEEIQKYYRREKYGPYVVDPHTAVGLTAQERSAKKASPDTTWITLSTAHPAKFSGAVELALSASEFPDFDFRRDVLPDELKKLEGLEKRVHRVKGEEGVRALIEKVKSASHEKVDAEEGRGSL" }, { "InterPro": [ { "InterPro-ID": "IPR014721", "InterPro-Name": "Ribsml_uS5_D2-typ_fold_subgr", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 5, "End": 173 }, { "InterPro-ID": "IPR006203", "InterPro-Name": "GHMP_knse_ATP-bd_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 98, "End": 109 }, { "InterPro-ID": "IPR036554", "InterPro-Name": "GHMP_kinase_C_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 210, "End": 332 }, { "InterPro-ID": "IPR020568", "InterPro-Name": "Ribosomal_Su5_D2-typ_SF", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 6, "End": 157 }, { "InterPro-ID": "IPR006204", "InterPro-Name": "GHMP_kinase_N_dom", "InterPro-Type": "DOMAIN", "Beg": 68, "End": 152 }, { "InterPro-ID": "IPR000870", "InterPro-Name": "Homoserine_kinase", "InterPro-Type": "FAMILY", "Beg": 2, "End": 354 }, { "InterPro-ID": "IPR013750", "InterPro-Name": "GHMP_kinase_C_dom", "InterPro-Type": "DOMAIN", "Beg": 259, "End": 326 }, { "InterPro-ID": "IPR000870", "InterPro-Name": "Homoserine_kinase", "InterPro-Type": "FAMILY", "Beg": 7, "End": 352 }, { "InterPro-ID": "IPR000870", "InterPro-Name": "Homoserine_kinase", "InterPro-Type": "FAMILY", "Beg": 6, "End": 352 }, { "InterPro-ID": "IPR036554", "InterPro-Name": "GHMP_kinase_C_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 207, "End": 339 } ], "response#1": "MPARKYKIHVPCTSANIGPGFDVCGIALSLSLSLVVTIPSVSSGAEPLPKIIYTGLDSDNVPLSPYKNLLTRVALYVLRANGITTFPPGVTIEARNEIPFGRGLGSSGAAVIAGVLLGDLLGNLSLPKSRLLDFALMVERHPDNVTAALMGGFVGSYLRELSPEDMSAASIPLAEVLPEYPPDAGPDWGKSPPQPPHGIGHFVRFGWAKEIKAIAVSPRFELATAKARGVLPESYSRKDMIFNLQRLAVLTTALARSPPDPDLIYDAMGDRVHQPYRMTLIPGLPKILSTLTPTSHPGLLGICLSGAGPTILALATHNFEAIANEIERIFGDEQVLVDHKVLNIDEKGSWVEDITEA", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more GHMP_kinase_N_dom, GHMP_kinase_C_dom that are essential for its biological function; 2. The protein should belong to Homoserine_kinase, Homoserine_kinase, Homoserine_kinase that shares evolutionary origin and functional similarity; 3. The protein should be classified within Ribsml_uS5_D2-typ_fold_subgr, GHMP_kinase_C_sf, Ribosomal_Su5_D2-typ_SF, GHMP_kinase_C_sf sharing conserved structural features; 4. The protein should contain GHMP_knse_ATP-bd_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MPARKYKIHVPCTSANIGPGFDVCGIALSLSLSLVVTIPSVSSGAEPLPKIIYTGLDSDNVPLSPYKNLLTRVALYVLRANGITTFPPGVTIEARNEIPFGRGLGSSGAAVIAGVLLGDLLGNLSLPKSRLLDFALMVERHPDNVTAALMGGFVGSYLRELSPEDMSAASIPLAEVLPEYPPDAGPDWGKSPPQPPHGIGHFVRFGWAKEIKAIAVSPRFELATAKARGVLPESYSRKDMIFNLQRLAVLTTALARSPPDPDLIYDAMGDRVHQPYRMTLIPGLPKILSTLTPTSHPGLLGICLSGAGPTILALATHNFEAIANEIERIFGDEQVLVDHKVLNIDEKGSWVEDITEA" }, { "InterPro": [ { "InterPro-ID": "IPR050121", "InterPro-Name": "Cytochrome_P450_monoxygenase", "InterPro-Type": "FAMILY", "Beg": 117, "End": 293 }, { "InterPro-ID": "IPR036396", "InterPro-Name": "Cyt_P450_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 88, "End": 293 }, { "InterPro-ID": "IPR036396", "InterPro-Name": "Cyt_P450_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 9, "End": 297 }, { "InterPro-ID": "IPR002403", "InterPro-Name": "Cyt_P450_E_grp-IV", "InterPro-Type": "FAMILY", "Beg": 198, "End": 214 }, { "InterPro-ID": "IPR002403", "InterPro-Name": "Cyt_P450_E_grp-IV", "InterPro-Type": "FAMILY", "Beg": 252, "End": 270 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 89, "End": 292 } ], "response#1": "MNDFVFSDIPDILKPMASVEFDDPLTKATGDVLNWTLWLIRNFPALSNIIMRLPSSLVSIVTSSFEGANQMFQVTTSTHNLYSASLPTHATKQIISKLVEHEKTHIGPKNKDCVVQRLLNAHRDSESKISIPTPDATVRSEAIGFTLAGTADPPNILALGTFMAARDPEMQEGLYKELRAVWPDLRSPVPSYNLLHQLPLLRGVVKESIRFTHGVATGPARLVGAGGARIGGYNVPAKASLAVVAAPSYFVHMDETVFSEPEKFEPRRWADNDYSKSLVAFSRGRRMCPAEQFHVEPYETTSVPRSEERG", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Cytochrome_P450_monoxygenase, Cyt_P450_E_grp-IV, Cyt_P450_E_grp-IV, Cyt_P450 that shares evolutionary origin and functional similarity; 2. The protein should be classified within Cyt_P450_sf, Cyt_P450_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MNDFVFSDIPDILKPMASVEFDDPLTKATGDVLNWTLWLIRNFPALSNIIMRLPSSLVSIVTSSFEGANQMFQVTTSTHNLYSASLPTHATKQIISKLVEHEKTHIGPKNKDCVVQRLLNAHRDSESKISIPTPDATVRSEAIGFTLAGTADPPNILALGTFMAARDPEMQEGLYKELRAVWPDLRSPVPSYNLLHQLPLLRGVVKESIRFTHGVATGPARLVGAGGARIGGYNVPAKASLAVVAAPSYFVHMDETVFSEPEKFEPRRWADNDYSKSLVAFSRGRRMCPAEQFHVEPYETTSVPRSEERG" }, { "InterPro": [ { "InterPro-ID": "IPR027443", "InterPro-Name": "IPNS-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 36, "End": 370 }, { "InterPro-ID": "IPR026992", "InterPro-Name": "DIOX_N", "InterPro-Type": "DOMAIN", "Beg": 42, "End": 149 }, { "InterPro-ID": "IPR005123", "InterPro-Name": "Oxoglu/Fe-dep_dioxygenase_dom", "InterPro-Type": "DOMAIN", "Beg": 220, "End": 330 }, { "InterPro-ID": "IPR050231", "InterPro-Name": "Iron_ascorbate_oxido_reductase", "InterPro-Type": "FAMILY", "Beg": 42, "End": 333 }, { "InterPro-ID": "IPR044861", "InterPro-Name": "IPNS-like_FE2OG_OXY", "InterPro-Type": "DOMAIN", "Beg": 224, "End": 328 } ], "response#1": "MATDTAVTGAPETMQLRLASGNGPVTRTVLRTPLRDALPSEVPLIDISPIFSTSVADRKAVACKIHDAATNIGFFYIQNHRVPSRDTDMAYSASLDFFRQDMEAKMKADAKKGPFDSGYRGPGTQRVNPDEGADLRETYSILYDPMLDPTVPDPARIPEPASRFLHLGRAPFESTDTLPHFKDAFVRYFQACLALARALTRTFALSLDLPESAFDSKVQYPDASLEINFYPPISTGHAVSAPADPDTRVSIGSHTDFLLFTILWQDSNGGLQVLNREGQWIRASPVEGTFVVNIGDYLQRITNDKYVSTVHRAQNWSGRQRVSMPFFWGFGMHESCQVLESCCGEDGKSKYDEVRCVDWVSRRLGNLFDLSDKG", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more DIOX_N, Oxoglu/Fe-dep_dioxygenase_dom, IPNS-like_FE2OG_OXY that are essential for its biological function; 2. The protein should belong to Iron_ascorbate_oxido_reductase that shares evolutionary origin and functional similarity; 3. The protein should be classified within IPNS-like_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MATDTAVTGAPETMQLRLASGNGPVTRTVLRTPLRDALPSEVPLIDISPIFSTSVADRKAVACKIHDAATNIGFFYIQNHRVPSRDTDMAYSASLDFFRQDMEAKMKADAKKGPFDSGYRGPGTQRVNPDEGADLRETYSILYDPMLDPTVPDPARIPEPASRFLHLGRAPFESTDTLPHFKDAFVRYFQACLALARALTRTFALSLDLPESAFDSKVQYPDASLEINFYPPISTGHAVSAPADPDTRVSIGSHTDFLLFTILWQDSNGGLQVLNREGQWIRASPVEGTFVVNIGDYLQRITNDKYVSTVHRAQNWSGRQRVSMPFFWGFGMHESCQVLESCCGEDGKSKYDEVRCVDWVSRRLGNLFDLSDKG" }, { "InterPro": [ { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 47, "End": 456 }, { "InterPro-ID": "IPR036396", "InterPro-Name": "Cyt_P450_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 14, "End": 460 }, { "InterPro-ID": "IPR050121", "InterPro-Name": "Cytochrome_P450_monoxygenase", "InterPro-Type": "FAMILY", "Beg": 12, "End": 456 }, { "InterPro-ID": "IPR036396", "InterPro-Name": "Cyt_P450_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 23, "End": 456 }, { "InterPro-ID": "IPR017972", "InterPro-Name": "Cyt_P450_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 445, "End": 454 }, { "InterPro-ID": "IPR002403", "InterPro-Name": "Cyt_P450_E_grp-IV", "InterPro-Type": "FAMILY", "Beg": 410, "End": 428 }, { "InterPro-ID": "IPR002403", "InterPro-Name": "Cyt_P450_E_grp-IV", "InterPro-Type": "FAMILY", "Beg": 341, "End": 357 }, { "InterPro-ID": "IPR002403", "InterPro-Name": "Cyt_P450_E_grp-IV", "InterPro-Type": "FAMILY", "Beg": 436, "End": 452 } ], "response#1": "MLSIDHVDWLELIRVTLHPLAKFPGPKLAGASYCYEFWYEVICGIQYTQKIIKLHEQYGPIVRINPDELHFNDVDFVDVVYTAGARKRDKSSHYLAGFGGVSKSTFGTLDHMHHRTRRRALNKFFSKSRVLQIEDSIHEKSQQLCDKFLAYRDQGPFDLTGAFSCIATDTVTEYCFGSSPGFLNQDGWEPNCKSYFETIERMAHVTRHVPWILYLAKWLPLSIIRLVSSDLNSFLVDTRVKKPERLKRVVLDAERHDAKDCPVFLELLNSDLPPREKSKQRFMYEANGATLAGSGSTAIAMSNIVYNLVANPRIGHKLRSELLGKVSDPKNLPRWSSLEELPYLTAVIHEGLRSMYDPSKERLPYDPSQERLPRIATEEELIYKDGSTPGKSKYVIPRGYAIGTSAHVVHSDESIFPNASQFNPERWLGRDGQRNRELERHLLSFSKGSRYCLGMHCRCTTCLALPASVRNGTRGY", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Cyt_P450, Cytochrome_P450_monoxygenase, Cyt_P450_E_grp-IV, Cyt_P450_E_grp-IV, Cyt_P450_E_grp-IV that shares evolutionary origin and functional similarity; 2. The protein should be classified within Cyt_P450_sf, Cyt_P450_sf sharing conserved structural features; 3. The protein should contain Cyt_P450_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MLSIDHVDWLELIRVTLHPLAKFPGPKLAGASYCYEFWYEVICGIQYTQKIIKLHEQYGPIVRINPDELHFNDVDFVDVVYTAGARKRDKSSHYLAGFGGVSKSTFGTLDHMHHRTRRRALNKFFSKSRVLQIEDSIHEKSQQLCDKFLAYRDQGPFDLTGAFSCIATDTVTEYCFGSSPGFLNQDGWEPNCKSYFETIERMAHVTRHVPWILYLAKWLPLSIIRLVSSDLNSFLVDTRVKKPERLKRVVLDAERHDAKDCPVFLELLNSDLPPREKSKQRFMYEANGATLAGSGSTAIAMSNIVYNLVANPRIGHKLRSELLGKVSDPKNLPRWSSLEELPYLTAVIHEGLRSMYDPSKERLPYDPSQERLPRIATEEELIYKDGSTPGKSKYVIPRGYAIGTSAHVVHSDESIFPNASQFNPERWLGRDGQRNRELERHLLSFSKGSRYCLGMHCRCTTCLALPASVRNGTRGY" }, { "InterPro": [ { "InterPro-ID": "IPR036728", "InterPro-Name": "PBP_GOBP_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 23, "End": 138 }, { "InterPro-ID": "IPR036728", "InterPro-Name": "PBP_GOBP_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 30, "End": 123 } ], "response#1": "MSFLFFLVVLISIGLWVGPCVADNPENRCIKQFAKTNPACIVHCKYNLYKFTDDNYDITDQHINKFTDVLIKNKAVDGSKKSQVQEHLKKCAEESLKKTHGKNCQRLVEYYSCAVDNKLIDYFKYESAINSYDRSIYTPPYSG", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should be classified within PBP_GOBP_sf, PBP_GOBP_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MSFLFFLVVLISIGLWVGPCVADNPENRCIKQFAKTNPACIVHCKYNLYKFTDDNYDITDQHINKFTDVLIKNKAVDGSKKSQVQEHLKKCAEESLKKTHGKNCQRLVEYYSCAVDNKLIDYFKYESAINSYDRSIYTPPYSG" }, { "InterPro": [ { "InterPro-ID": "IPR002487", "InterPro-Name": "TF_Kbox", "InterPro-Type": "DOMAIN", "Beg": 82, "End": 169 }, { "InterPro-ID": "IPR002487", "InterPro-Name": "TF_Kbox", "InterPro-Type": "DOMAIN", "Beg": 85, "End": 175 }, { "InterPro-ID": "IPR002100", "InterPro-Name": "TF_MADSbox", "InterPro-Type": "DOMAIN", "Beg": 10, "End": 57 }, { "InterPro-ID": "IPR050142", "InterPro-Name": "MADS-box/MEF2_TF", "InterPro-Type": "FAMILY", "Beg": 3, "End": 188 }, { "InterPro-ID": "IPR033896", "InterPro-Name": "MEF2-like_N", "InterPro-Type": "DOMAIN", "Beg": 2, "End": 72 }, { "InterPro-ID": "IPR002100", "InterPro-Name": "TF_MADSbox", "InterPro-Type": "DOMAIN", "Beg": 1, "End": 61 }, { "InterPro-ID": "IPR036879", "InterPro-Name": "TF_MADSbox_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 2, "End": 77 }, { "InterPro-ID": "IPR036879", "InterPro-Name": "TF_MADSbox_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 13, "End": 80 }, { "InterPro-ID": "IPR002100", "InterPro-Name": "TF_MADSbox", "InterPro-Type": "DOMAIN", "Beg": 3, "End": 57 }, { "InterPro-ID": "IPR002100", "InterPro-Name": "TF_MADSbox", "InterPro-Type": "DOMAIN", "Beg": 3, "End": 23 }, { "InterPro-ID": "IPR002100", "InterPro-Name": "TF_MADSbox", "InterPro-Type": "DOMAIN", "Beg": 38, "End": 59 }, { "InterPro-ID": "IPR002100", "InterPro-Name": "TF_MADSbox", "InterPro-Type": "DOMAIN", "Beg": 23, "End": 38 }, { "InterPro-ID": "IPR002100", "InterPro-Name": "TF_MADSbox", "InterPro-Type": "DOMAIN", "Beg": 1, "End": 60 } ], "response#1": "MGRGRVELKRIENKINRQVTFSKRRNGLLKKAYELSVLCEAEVALIIFSSRGKLYEFGSAGITKTLERYQRCCLNPQDNCGERETQSWYQEVSKLKAKFEALQRTQRHLLGEDLGALSVKELQNLEKQLEGALAQARQRKTQIMMEQMEELRRKERHLGDVNKQLKIKVSLELSSFEGEGQGVPFPWSNCNASLDEAGSSTFHVHHSQSNHMDCDLPDPVLQIGYHQYMAADGASGSRNMAVESNIIHGWGL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more TF_Kbox, TF_Kbox, TF_MADSbox, MEF2-like_N, TF_MADSbox, TF_MADSbox, TF_MADSbox, TF_MADSbox, TF_MADSbox, TF_MADSbox that are essential for its biological function; 2. The protein should belong to MADS-box/MEF2_TF that shares evolutionary origin and functional similarity; 3. The protein should be classified within TF_MADSbox_sf, TF_MADSbox_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MGRGRVELKRIENKINRQVTFSKRRNGLLKKAYELSVLCEAEVALIIFSSRGKLYEFGSAGITKTLERYQRCCLNPQDNCGERETQSWYQEVSKLKAKFEALQRTQRHLLGEDLGALSVKELQNLEKQLEGALAQARQRKTQIMMEQMEELRRKERHLGDVNKQLKIKVSLELSSFEGEGQGVPFPWSNCNASLDEAGSSTFHVHHSQSNHMDCDLPDPVLQIGYHQYMAADGASGSRNMAVESNIIHGWGL" }, { "InterPro": [ { "InterPro-ID": "IPR050402", "InterPro-Name": "OR51/52/56-like", "InterPro-Type": "FAMILY", "Beg": 8, "End": 308 }, { "InterPro-ID": "IPR000276", "InterPro-Name": "GPCR_Rhodpsn", "InterPro-Type": "FAMILY", "Beg": 110, "End": 126 }, { "InterPro-ID": "IPR000276", "InterPro-Name": "GPCR_Rhodpsn", "InterPro-Type": "FAMILY", "Beg": 35, "End": 307 }, { "InterPro-ID": "IPR000725", "InterPro-Name": "Olfact_rcpt", "InterPro-Type": "FAMILY", "Beg": 129, "End": 141 }, { "InterPro-ID": "IPR000725", "InterPro-Name": "Olfact_rcpt", "InterPro-Type": "FAMILY", "Beg": 236, "End": 245 }, { "InterPro-ID": "IPR000725", "InterPro-Name": "Olfact_rcpt", "InterPro-Type": "FAMILY", "Beg": 285, "End": 296 }, { "InterPro-ID": "IPR000725", "InterPro-Name": "Olfact_rcpt", "InterPro-Type": "FAMILY", "Beg": 176, "End": 192 }, { "InterPro-ID": "IPR000725", "InterPro-Name": "Olfact_rcpt", "InterPro-Type": "FAMILY", "Beg": 92, "End": 103 }, { "InterPro-ID": "IPR000725", "InterPro-Name": "Olfact_rcpt", "InterPro-Type": "FAMILY", "Beg": 31, "End": 310 }, { "InterPro-ID": "IPR017452", "InterPro-Name": "GPCR_Rhodpsn_7TM", "InterPro-Type": "DOMAIN", "Beg": 41, "End": 292 }, { "InterPro-ID": "IPR000276", "InterPro-Name": "GPCR_Rhodpsn", "InterPro-Type": "FAMILY", "Beg": 199, "End": 222 }, { "InterPro-ID": "IPR000276", "InterPro-Name": "GPCR_Rhodpsn", "InterPro-Type": "FAMILY", "Beg": 104, "End": 126 }, { "InterPro-ID": "IPR000276", "InterPro-Name": "GPCR_Rhodpsn", "InterPro-Type": "FAMILY", "Beg": 26, "End": 50 }, { "InterPro-ID": "IPR000276", "InterPro-Name": "GPCR_Rhodpsn", "InterPro-Type": "FAMILY", "Beg": 274, "End": 300 }, { "InterPro-ID": "IPR000276", "InterPro-Name": "GPCR_Rhodpsn", "InterPro-Type": "FAMILY", "Beg": 59, "End": 80 } ], "response#1": "MGSNITSTSIIFLLTGVPGLEAFHTWISIPFCFLSVTALLGNSLILFATITQPSLHEPMYYFLSMLSATDLGLSISTLVTMLSIFWFNVREISFNACLSHMFFIKFFTVMESSVLLAMAFDRFVAVSNPLRYAMILTDSRIAQIGVASVIRGLLMLTPMVALLIRLSYCHSQVLHHSYCYHPDVMKLSCTDTRINSAVGLTAMFSTVGVDLLLILLSYVLIIRTVLSVASPEERKETFSTCVSHIVAFAIYYIPLISLSIVHRFGKQAPAYVHTMIANTYLLISPLMNPVIYSVKTKQIRRAVIKILHSKET", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more GPCR_Rhodpsn_7TM that are essential for its biological function; 2. The protein should belong to OR51/52/56-like, GPCR_Rhodpsn, GPCR_Rhodpsn, Olfact_rcpt, Olfact_rcpt, Olfact_rcpt, Olfact_rcpt, Olfact_rcpt, Olfact_rcpt, GPCR_Rhodpsn, GPCR_Rhodpsn, GPCR_Rhodpsn, GPCR_Rhodpsn, GPCR_Rhodpsn that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MGSNITSTSIIFLLTGVPGLEAFHTWISIPFCFLSVTALLGNSLILFATITQPSLHEPMYYFLSMLSATDLGLSISTLVTMLSIFWFNVREISFNACLSHMFFIKFFTVMESSVLLAMAFDRFVAVSNPLRYAMILTDSRIAQIGVASVIRGLLMLTPMVALLIRLSYCHSQVLHHSYCYHPDVMKLSCTDTRINSAVGLTAMFSTVGVDLLLILLSYVLIIRTVLSVASPEERKETFSTCVSHIVAFAIYYIPLISLSIVHRFGKQAPAYVHTMIANTYLLISPLMNPVIYSVKTKQIRRAVIKILHSKET" }, { "InterPro": [ { "InterPro-ID": "IPR001878", "InterPro-Name": "Znf_CCHC", "InterPro-Type": "DOMAIN", "Beg": 239, "End": 255 }, { "InterPro-ID": "IPR001878", "InterPro-Name": "Znf_CCHC", "InterPro-Type": "DOMAIN", "Beg": 239, "End": 254 }, { "InterPro-ID": "IPR001878", "InterPro-Name": "Znf_CCHC", "InterPro-Type": "DOMAIN", "Beg": 240, "End": 255 }, { "InterPro-ID": "IPR036875", "InterPro-Name": "Znf_CCHC_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 229, "End": 261 } ], "response#1": "MAGKNMSSRLLNMKFMQRASASTPTTPTTPDGTRPSKRLRTEAAPSPETRAFQEAAAAEEAKKNAFIERAAAEAGETKWVLSVSDDKPKTAGQGLRIVEAGYGAIDSGAPIPESDDDQDEEQSAGMAGRRSFGKFNKAVERQHNPDLSSPESEQDSDASSDSDSDDDEDLDEAELLIKAERKEAAAKLRAERKAQRKADEVKSKQMAERRRSRDINLNKVGGISNAAIRNKQANVANMACHVCGQKGHLQKDCPDRKQRRGDKRKSGGAMDY", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Znf_CCHC, Znf_CCHC, Znf_CCHC that are essential for its biological function; 2. The protein should be classified within Znf_CCHC_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MAGKNMSSRLLNMKFMQRASASTPTTPTTPDGTRPSKRLRTEAAPSPETRAFQEAAAAEEAKKNAFIERAAAEAGETKWVLSVSDDKPKTAGQGLRIVEAGYGAIDSGAPIPESDDDQDEEQSAGMAGRRSFGKFNKAVERQHNPDLSSPESEQDSDASSDSDSDDDEDLDEAELLIKAERKEAAAKLRAERKAQRKADEVKSKQMAERRRSRDINLNKVGGISNAAIRNKQANVANMACHVCGQKGHLQKDCPDRKQRRGDKRKSGGAMDY" }, { "InterPro": [ { "InterPro-ID": "IPR029058", "InterPro-Name": "AB_hydrolase_fold", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1, "End": 247 }, { "InterPro-ID": "IPR005645", "InterPro-Name": "FSH-like_dom", "InterPro-Type": "DOMAIN", "Beg": 2, "End": 232 }, { "InterPro-ID": "IPR029058", "InterPro-Name": "AB_hydrolase_fold", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 4, "End": 243 }, { "InterPro-ID": "IPR050593", "InterPro-Name": "LovG", "InterPro-Type": "FAMILY", "Beg": 1, "End": 244 } ], "response#1": "MKFLCLHGAYGNIPAFRVQLGPMIDALEFDGSASFEFIQGRVSVVPPPGFESYFGPAPHYRFLKDRGEAEASAVEGIRVFPEAETPEDALRALMPRDDMEIGFADARGLALEQLYEALDADPEISGIIGYSEGASAAATLVYDEQERMRSEGYVPRIKAAIFFMGWPALTAENVPALSDEVENLLEVPSLHIVGANDPYKDGALALYNIFDDNMAVFFDSAGGHTIPRHGKLLQELVSAVKDLIADVPEDNSADLLAPAVTGKRLDSAVDIPNLSFLKNEDA", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more FSH-like_dom that are essential for its biological function; 2. The protein should belong to LovG that shares evolutionary origin and functional similarity; 3. The protein should be classified within AB_hydrolase_fold, AB_hydrolase_fold sharing conserved structural features. The designed protein sequence is ", "reference": "MKFLCLHGAYGNIPAFRVQLGPMIDALEFDGSASFEFIQGRVSVVPPPGFESYFGPAPHYRFLKDRGEAEASAVEGIRVFPEAETPEDALRALMPRDDMEIGFADARGLALEQLYEALDADPEISGIIGYSEGASAAATLVYDEQERMRSEGYVPRIKAAIFFMGWPALTAENVPALSDEVENLLEVPSLHIVGANDPYKDGALALYNIFDDNMAVFFDSAGGHTIPRHGKLLQELVSAVKDLIADVPEDNSADLLAPAVTGKRLDSAVDIPNLSFLKNEDA" }, { "InterPro": [ { "InterPro-ID": "IPR036291", "InterPro-Name": "NAD(P)-bd_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 157, "End": 322 }, { "InterPro-ID": "IPR013149", "InterPro-Name": "ADH-like_C", "InterPro-Type": "DOMAIN", "Beg": 189, "End": 321 }, { "InterPro-ID": "IPR013154", "InterPro-Name": "ADH-like_N", "InterPro-Type": "DOMAIN", "Beg": 39, "End": 151 }, { "InterPro-ID": "IPR045306", "InterPro-Name": "SDH-like", "InterPro-Type": "FAMILY", "Beg": 36, "End": 360 }, { "InterPro-ID": "IPR011032", "InterPro-Name": "GroES-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 28, "End": 187 } ], "response#1": "MVKPTKSNIGVYTNPAHDLWVAEAEPSLEQVQTGEKLAPGEVTVAVKSTGICGSDVHFWHAGCIGPMIVEDDHILGHESAGVVVAVHENVKSLKVGDRVAIEPNIICGECEPCLTGRYNGCDSVLFRSTPPVPGLLRRYVNHPAMWCHKIGDMSYENGSLLEPLSVALAGVQRAEVRLGDPILVCGAGPIGLVTLACVKAAGAEPIIITDIDEGRLAFAKEFCPSVRTHKVDFKHTPEDFAKAITELGGGVEPAIALECTGVESSIAGAIQTVKFGGKVFVIGVGKNEIKIPFMRLSTREVDLQFQYRYANTWPRAIRLLQGGVINLEKLVTHRFKIEDALEAFKTAADPKTGAIKVQIQSFEEGESR", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more ADH-like_C, ADH-like_N that are essential for its biological function; 2. The protein should belong to SDH-like that shares evolutionary origin and functional similarity; 3. The protein should be classified within NAD(P)-bd_dom_sf, GroES-like_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MVKPTKSNIGVYTNPAHDLWVAEAEPSLEQVQTGEKLAPGEVTVAVKSTGICGSDVHFWHAGCIGPMIVEDDHILGHESAGVVVAVHENVKSLKVGDRVAIEPNIICGECEPCLTGRYNGCDSVLFRSTPPVPGLLRRYVNHPAMWCHKIGDMSYENGSLLEPLSVALAGVQRAEVRLGDPILVCGAGPIGLVTLACVKAAGAEPIIITDIDEGRLAFAKEFCPSVRTHKVDFKHTPEDFAKAITELGGGVEPAIALECTGVESSIAGAIQTVKFGGKVFVIGVGKNEIKIPFMRLSTREVDLQFQYRYANTWPRAIRLLQGGVINLEKLVTHRFKIEDALEAFKTAADPKTGAIKVQIQSFEEGESR" }, { "InterPro": [ { "InterPro-ID": "IPR014795", "InterPro-Name": "TacA_1-like", "InterPro-Type": "FAMILY", "Beg": 63, "End": 156 }, { "InterPro-ID": "IPR010985", "InterPro-Name": "Ribbon_hlx_hlx", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 71, "End": 148 }, { "InterPro-ID": "IPR016547", "InterPro-Name": "TacA", "InterPro-Type": "FAMILY", "Beg": 1, "End": 158 }, { "InterPro-ID": "IPR014795", "InterPro-Name": "TacA_1-like", "InterPro-Type": "FAMILY", "Beg": 74, "End": 150 } ], "response#1": "MHRAGAAVTANVWCRAGGIRMAPRPVIPVATQQRLRRQADRQSLGSSGLPALNCTPIRHTIDVMATKPERKTERLAARLTPEQDALIRRAAEAEGTDLTNFTVTAALAHARDVLADRRLFVLTDAAWTEFLAALDRPVSHKPRLEKLFAARSIFDTEG", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to TacA_1-like, TacA, TacA_1-like that shares evolutionary origin and functional similarity; 2. The protein should be classified within Ribbon_hlx_hlx sharing conserved structural features. The designed protein sequence is ", "reference": "MHRAGAAVTANVWCRAGGIRMAPRPVIPVATQQRLRRQADRQSLGSSGLPALNCTPIRHTIDVMATKPERKTERLAARLTPEQDALIRRAAEAEGTDLTNFTVTAALAHARDVLADRRLFVLTDAAWTEFLAALDRPVSHKPRLEKLFAARSIFDTEG" }, { "InterPro": [ { "InterPro-ID": "IPR026992", "InterPro-Name": "DIOX_N", "InterPro-Type": "DOMAIN", "Beg": 20, "End": 154 }, { "InterPro-ID": "IPR044861", "InterPro-Name": "IPNS-like_FE2OG_OXY", "InterPro-Type": "DOMAIN", "Beg": 204, "End": 309 }, { "InterPro-ID": "IPR050231", "InterPro-Name": "Iron_ascorbate_oxido_reductase", "InterPro-Type": "FAMILY", "Beg": 37, "End": 340 }, { "InterPro-ID": "IPR005123", "InterPro-Name": "Oxoglu/Fe-dep_dioxygenase_dom", "InterPro-Type": "DOMAIN", "Beg": 200, "End": 311 }, { "InterPro-ID": "IPR027443", "InterPro-Name": "IPNS-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 8, "End": 349 } ], "response#1": "MRSVSPQSTMARIPERRVRTLDFAQFRHGEPSGSRGFCRELVDCLSSVGFVKIRNHGISGQEIENVFVMSQLFFSLPQAAKGKAAHPPEANPHRGYSYVGQEKLSRVKDYEKGKREITDVYDIKHYPIDRDARQESYDQGAAVDNLYPNRWPDEQDIPGFRVLMETFYERCHEVHQDILRAIAIGFDLSPSFLTDLCCQNTSELRLNHYPSVHPSSLRKGAKRISEHTDFGTVTLLFQDSVGGLEIEDQNTPGTYFPVLSERKSDIIVNIGDCIQRWTNDKIHSTSHRVVLPEDTDALTKDRYSVAYFGKPSRSQLVGSLREFVKEGEKPKYNDISAWQYNQEKLVLTY", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more DIOX_N, IPNS-like_FE2OG_OXY, Oxoglu/Fe-dep_dioxygenase_dom that are essential for its biological function; 2. The protein should belong to Iron_ascorbate_oxido_reductase that shares evolutionary origin and functional similarity; 3. The protein should be classified within IPNS-like_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MRSVSPQSTMARIPERRVRTLDFAQFRHGEPSGSRGFCRELVDCLSSVGFVKIRNHGISGQEIENVFVMSQLFFSLPQAAKGKAAHPPEANPHRGYSYVGQEKLSRVKDYEKGKREITDVYDIKHYPIDRDARQESYDQGAAVDNLYPNRWPDEQDIPGFRVLMETFYERCHEVHQDILRAIAIGFDLSPSFLTDLCCQNTSELRLNHYPSVHPSSLRKGAKRISEHTDFGTVTLLFQDSVGGLEIEDQNTPGTYFPVLSERKSDIIVNIGDCIQRWTNDKIHSTSHRVVLPEDTDALTKDRYSVAYFGKPSRSQLVGSLREFVKEGEKPKYNDISAWQYNQEKLVLTY" }, { "InterPro": [ { "InterPro-ID": "IPR000524", "InterPro-Name": "Tscrpt_reg_HTH_GntR", "InterPro-Type": "DOMAIN", "Beg": 21, "End": 80 }, { "InterPro-ID": "IPR000524", "InterPro-Name": "Tscrpt_reg_HTH_GntR", "InterPro-Type": "DOMAIN", "Beg": 15, "End": 83 }, { "InterPro-ID": "IPR036388", "InterPro-Name": "WH-like_DNA-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 14, "End": 120 }, { "InterPro-ID": "IPR036390", "InterPro-Name": "WH_DNA-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 11, "End": 90 }, { "InterPro-ID": "IPR000524", "InterPro-Name": "Tscrpt_reg_HTH_GntR", "InterPro-Type": "DOMAIN", "Beg": 16, "End": 81 } ], "response#1": "MELRDWLRVDVKAGKPLFDQLRTQVIDGVRAGALPPGTRLPTVRDLAGQLGVAANTVARAYRELESAAIVETRGRFGTFISRFDPTDAAMAAAAKEYVGVARALGLTKSDAMRYLTHVPDD", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Tscrpt_reg_HTH_GntR, Tscrpt_reg_HTH_GntR, Tscrpt_reg_HTH_GntR that are essential for its biological function; 2. The protein should be classified within WH-like_DNA-bd_sf, WH_DNA-bd_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MELRDWLRVDVKAGKPLFDQLRTQVIDGVRAGALPPGTRLPTVRDLAGQLGVAANTVARAYRELESAAIVETRGRFGTFISRFDPTDAAMAAAAKEYVGVARALGLTKSDAMRYLTHVPDD" }, { "InterPro": [ { "InterPro-ID": "IPR022803", "InterPro-Name": "Ribosomal_uL5_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 2, "End": 173 }, { "InterPro-ID": "IPR031309", "InterPro-Name": "Ribosomal_uL5_C", "InterPro-Type": "DOMAIN", "Beg": 65, "End": 152 }, { "InterPro-ID": "IPR002132", "InterPro-Name": "Ribosomal_uL5", "InterPro-Type": "FAMILY", "Beg": 1, "End": 171 }, { "InterPro-ID": "IPR002132", "InterPro-Name": "Ribosomal_uL5", "InterPro-Type": "FAMILY", "Beg": 2, "End": 171 }, { "InterPro-ID": "IPR031310", "InterPro-Name": "Ribosomal_uL5_N", "InterPro-Type": "DOMAIN", "Beg": 8, "End": 61 }, { "InterPro-ID": "IPR022803", "InterPro-Name": "Ribosomal_uL5_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 8, "End": 172 }, { "InterPro-ID": "IPR020929", "InterPro-Name": "Ribosomal_uL5_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 38, "End": 54 } ], "response#1": "MSSEKAQNPMRELRIQKLVLNISVGESGDRLTRAAKVLEQLSGQTPVYSKARYTVRQFGIRRNEKIAVHVTVRGPKAEEILERGLKVKEYELRRRNFSETGNFGFGISEHIDLGIKYDPSIGIYGMDFYCCMTRPGERVAKRRRCKSRIGASHRITREETIRWFKQRFDGIVR", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Ribosomal_uL5_C, Ribosomal_uL5_N that are essential for its biological function; 2. The protein should belong to Ribosomal_uL5, Ribosomal_uL5 that shares evolutionary origin and functional similarity; 3. The protein should be classified within Ribosomal_uL5_dom_sf, Ribosomal_uL5_dom_sf sharing conserved structural features; 4. The protein should contain Ribosomal_uL5_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MSSEKAQNPMRELRIQKLVLNISVGESGDRLTRAAKVLEQLSGQTPVYSKARYTVRQFGIRRNEKIAVHVTVRGPKAEEILERGLKVKEYELRRRNFSETGNFGFGISEHIDLGIKYDPSIGIYGMDFYCCMTRPGERVAKRRRCKSRIGASHRITREETIRWFKQRFDGIVR" }, { "InterPro": [ { "InterPro-ID": "IPR005485", "InterPro-Name": "Rbsml_uL18_euk/arc", "InterPro-Type": "FAMILY", "Beg": 1, "End": 300 }, { "InterPro-ID": "IPR025607", "InterPro-Name": "Ribosomal_uL18_C_euk", "InterPro-Type": "DOMAIN", "Beg": 239, "End": 300 }, { "InterPro-ID": "IPR005485", "InterPro-Name": "Rbsml_uL18_euk/arc", "InterPro-Type": "FAMILY", "Beg": 14, "End": 250 }, { "InterPro-ID": "IPR005485", "InterPro-Name": "Rbsml_uL18_euk/arc", "InterPro-Type": "FAMILY", "Beg": 14, "End": 179 }, { "InterPro-ID": "IPR005485", "InterPro-Name": "Rbsml_uL18_euk/arc", "InterPro-Type": "FAMILY", "Beg": 84, "End": 104 }, { "InterPro-ID": "IPR005485", "InterPro-Name": "Rbsml_uL18_euk/arc", "InterPro-Type": "FAMILY", "Beg": 168, "End": 187 }, { "InterPro-ID": "IPR005485", "InterPro-Name": "Rbsml_uL18_euk/arc", "InterPro-Type": "FAMILY", "Beg": 43, "End": 62 }, { "InterPro-ID": "IPR005485", "InterPro-Name": "Rbsml_uL18_euk/arc", "InterPro-Type": "FAMILY", "Beg": 148, "End": 167 }, { "InterPro-ID": "IPR005485", "InterPro-Name": "Rbsml_uL18_euk/arc", "InterPro-Type": "FAMILY", "Beg": 20, "End": 39 }, { "InterPro-ID": "IPR005485", "InterPro-Name": "Rbsml_uL18_euk/arc", "InterPro-Type": "FAMILY", "Beg": 210, "End": 230 } ], "response#1": "MAFHKLVKNSAYYSRFQTKFKRRRQGKTDYYARKRLITQAKNKYNAPKYRLVVRFTNRDIITQMVTSEINGDKIFAAAYSHELRAYGINHGLTNWAAAYATGLLLARRVLAKLGLDKTFTGVEEPNGEYTLTEAAETEDGERRPFKAILDVGLARTSTGARVFGVMKGASDGGIFIPHSENRFPGYDIETEELDTEVLKKYIYGGHVAEYMETLADDDEERYKSQFVKYIEDDVEADSLEELYAEAHKQIRADPFRKYVSDAPKKSKEEWKAESLKYKKAKLSREERKARVEAKIKQLLAEQDE", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Ribosomal_uL18_C_euk that are essential for its biological function; 2. The protein should belong to Rbsml_uL18_euk/arc, Rbsml_uL18_euk/arc, Rbsml_uL18_euk/arc, Rbsml_uL18_euk/arc, Rbsml_uL18_euk/arc, Rbsml_uL18_euk/arc, Rbsml_uL18_euk/arc, Rbsml_uL18_euk/arc, Rbsml_uL18_euk/arc that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MAFHKLVKNSAYYSRFQTKFKRRRQGKTDYYARKRLITQAKNKYNAPKYRLVVRFTNRDIITQMVTSEINGDKIFAAAYSHELRAYGINHGLTNWAAAYATGLLLARRVLAKLGLDKTFTGVEEPNGEYTLTEAAETEDGERRPFKAILDVGLARTSTGARVFGVMKGASDGGIFIPHSENRFPGYDIETEELDTEVLKKYIYGGHVAEYMETLADDDEERYKSQFVKYIEDDVEADSLEELYAEAHKQIRADPFRKYVSDAPKKSKEEWKAESLKYKKAKLSREERKARVEAKIKQLLAEQDE" }, { "InterPro": [ { "InterPro-ID": "IPR012674", "InterPro-Name": "Calycin", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 25, "End": 196 }, { "InterPro-ID": "IPR005657", "InterPro-Name": "Triabi/Procalin", "InterPro-Type": "FAMILY", "Beg": 24, "End": 165 }, { "InterPro-ID": "IPR012674", "InterPro-Name": "Calycin", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 23, "End": 171 } ], "response#1": "MKTILAVIFFGILAFAFADYPSIPKCTHPPAMANFNQKKFLEGKWYVTKAKHGSNSTVCREYRAKTKGNDQILVGDGYYSFNGGTFYFTVRCKRLPNKEVQKPLQFTCTQKSPDDPSKMFKFQLEVTILDTDYANYAVMYRCVQFPEELGSHFEDNTLLLHRKLDQLVDENLIERKLKLSLPSFKSRDDVVEGCRELPSKKKKTKP", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Triabi/Procalin that shares evolutionary origin and functional similarity; 2. The protein should be classified within Calycin, Calycin sharing conserved structural features. The designed protein sequence is ", "reference": "MKTILAVIFFGILAFAFADYPSIPKCTHPPAMANFNQKKFLEGKWYVTKAKHGSNSTVCREYRAKTKGNDQILVGDGYYSFNGGTFYFTVRCKRLPNKEVQKPLQFTCTQKSPDDPSKMFKFQLEVTILDTDYANYAVMYRCVQFPEELGSHFEDNTLLLHRKLDQLVDENLIERKLKLSLPSFKSRDDVVEGCRELPSKKKKTKP" }, { "InterPro": [ { "InterPro-ID": "IPR012674", "InterPro-Name": "Calycin", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 25, "End": 200 }, { "InterPro-ID": "IPR005657", "InterPro-Name": "Triabi/Procalin", "InterPro-Type": "FAMILY", "Beg": 22, "End": 164 }, { "InterPro-ID": "IPR012674", "InterPro-Name": "Calycin", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 25, "End": 198 } ], "response#1": "MKTILAVIFFGILAFAFADYPSIENCTHPPAMANFNQKKFLEGKWYVTKAKHGSNSTVCREYRAKTKGNDQILVGDGYYSFNGGTFYFTVRCKRLPNKEVQKPLQFTCTQKSTDDPSKMFKFQLEVTILDTDYANYAVMYRCVQFPEQLGSHFEDNTLLLHRNPDQLVDENQVERKLNLSFDSFRSREDVVDGCPKLPSKKKNKAS", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Triabi/Procalin that shares evolutionary origin and functional similarity; 2. The protein should be classified within Calycin, Calycin sharing conserved structural features. The designed protein sequence is ", "reference": "MKTILAVIFFGILAFAFADYPSIENCTHPPAMANFNQKKFLEGKWYVTKAKHGSNSTVCREYRAKTKGNDQILVGDGYYSFNGGTFYFTVRCKRLPNKEVQKPLQFTCTQKSTDDPSKMFKFQLEVTILDTDYANYAVMYRCVQFPEQLGSHFEDNTLLLHRNPDQLVDENQVERKLNLSFDSFRSREDVVDGCPKLPSKKKNKAS" }, { "InterPro": [ { "InterPro-ID": "IPR028359", "InterPro-Name": "UDP_ManNAc/GlcNAc_DH", "InterPro-Type": "FAMILY", "Beg": 4, "End": 423 }, { "InterPro-ID": "IPR014027", "InterPro-Name": "UDP-Glc/GDP-Man_DH_C", "InterPro-Type": "DOMAIN", "Beg": 326, "End": 420 }, { "InterPro-ID": "IPR008927", "InterPro-Name": "6-PGluconate_DH-like_C_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 214, "End": 307 }, { "InterPro-ID": "IPR017476", "InterPro-Name": "UDP-Glc/GDP-Man", "InterPro-Type": "FAMILY", "Beg": 14, "End": 421 }, { "InterPro-ID": "IPR014026", "InterPro-Name": "UDP-Glc/GDP-Man_DH_dimer", "InterPro-Type": "DOMAIN", "Beg": 215, "End": 305 }, { "InterPro-ID": "IPR028359", "InterPro-Name": "UDP_ManNAc/GlcNAc_DH", "InterPro-Type": "FAMILY", "Beg": 10, "End": 421 }, { "InterPro-ID": "IPR014027", "InterPro-Name": "UDP-Glc/GDP-Man_DH_C", "InterPro-Type": "DOMAIN", "Beg": 327, "End": 419 }, { "InterPro-ID": "IPR017476", "InterPro-Name": "UDP-Glc/GDP-Man", "InterPro-Type": "FAMILY", "Beg": 15, "End": 415 }, { "InterPro-ID": "IPR036220", "InterPro-Name": "UDP-Glc/GDP-Man_DH_C_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 321, "End": 419 }, { "InterPro-ID": "IPR036291", "InterPro-Name": "NAD(P)-bd_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 14, "End": 208 }, { "InterPro-ID": "IPR001732", "InterPro-Name": "UDP-Glc/GDP-Man_DH_N", "InterPro-Type": "DOMAIN", "Beg": 15, "End": 196 } ], "response#1": "MEKEKGEEKMNDSRKITVIGLGYVGLPLAIHFAERGYNVVGLDKDKRKIERIEKGDSYIPDVSSNVLKDLVQNKQLVVYTPHTGIEEFQNSEYVIVTVPTPINKQKEPDLSALIAASHYIKQNLQAGQTFIFESSTYPGTLEEVIIPIIAQSGKEVGKDYYIGYSPERIDPANQQYTVQTIPKVISGQTERCKQQVQKLYSTIFDTVVPVSSPKVAEMCKLFENIQRLVNISLVNELNILCEKLGIDFREALEAAATKPFGFTPYWPGPGIGGHCIPVDPLYFQWKARQLGQSSQLIEVAHMINEKMPQQIVTQVKELSAPPGTVFLIGIAYKKDVNDLRESPALPIIELLVNEGYKVQYHDPYISSAKIGDKIYDSIPLKKKTLEKADCILIVTDHSNIDWNICKGMKHVIDTRGVLKKVSA", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more UDP-Glc/GDP-Man_DH_C, UDP-Glc/GDP-Man_DH_dimer, UDP-Glc/GDP-Man_DH_C, UDP-Glc/GDP-Man_DH_N that are essential for its biological function; 2. The protein should belong to UDP_ManNAc/GlcNAc_DH, UDP-Glc/GDP-Man, UDP_ManNAc/GlcNAc_DH, UDP-Glc/GDP-Man that shares evolutionary origin and functional similarity; 3. The protein should be classified within 6-PGluconate_DH-like_C_sf, UDP-Glc/GDP-Man_DH_C_sf, NAD(P)-bd_dom_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MEKEKGEEKMNDSRKITVIGLGYVGLPLAIHFAERGYNVVGLDKDKRKIERIEKGDSYIPDVSSNVLKDLVQNKQLVVYTPHTGIEEFQNSEYVIVTVPTPINKQKEPDLSALIAASHYIKQNLQAGQTFIFESSTYPGTLEEVIIPIIAQSGKEVGKDYYIGYSPERIDPANQQYTVQTIPKVISGQTERCKQQVQKLYSTIFDTVVPVSSPKVAEMCKLFENIQRLVNISLVNELNILCEKLGIDFREALEAAATKPFGFTPYWPGPGIGGHCIPVDPLYFQWKARQLGQSSQLIEVAHMINEKMPQQIVTQVKELSAPPGTVFLIGIAYKKDVNDLRESPALPIIELLVNEGYKVQYHDPYISSAKIGDKIYDSIPLKKKTLEKADCILIVTDHSNIDWNICKGMKHVIDTRGVLKKVSA" }, { "InterPro": [ { "InterPro-ID": "IPR001604", "InterPro-Name": "Endo_G_ENPP1-like_dom", "InterPro-Type": "DOMAIN", "Beg": 125, "End": 335 }, { "InterPro-ID": "IPR040255", "InterPro-Name": "Non-specific_endonuclease", "InterPro-Type": "FAMILY", "Beg": 9, "End": 298 }, { "InterPro-ID": "IPR044929", "InterPro-Name": "DNA/RNA_non-sp_Endonuclease_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 124, "End": 336 }, { "InterPro-ID": "IPR044925", "InterPro-Name": "His-Me_finger_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 111, "End": 345 }, { "InterPro-ID": "IPR001604", "InterPro-Name": "Endo_G_ENPP1-like_dom", "InterPro-Type": "DOMAIN", "Beg": 110, "End": 344 } ], "response#1": "MSSFFLSISPLVLALFHVVVQVCSQSCQVAISELQSERKVIILNSDKRSLKQPSNGKYSWKSGESIYFICGKDLKTLTCSPSSINAKRFDCVKPPDVTERDINRECNGKSSKTFQMGFRASGGLFVPYYELCYLMDTCSVSHVKHRLLGASFGGVSGTREKSFQSFVCPGLRYNTHYTQASQKQPDPRFYFQRGHLFPDRDAPVFAWKLATYSYGNCVPQWNTINSEGGNWWTLEYLVFKYAQQTPNTEYTIYDGVLYDPRNKQYLAKQEKKIEIPVWFWKVVTNQTHVLKVFFVSHNLKGTKQTFCNTNRCVNDRAKGTKTVETWDFYNEASRGITHCCYWKDLARKNPLPIEVQREINNKKN", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Endo_G_ENPP1-like_dom, Endo_G_ENPP1-like_dom that are essential for its biological function; 2. The protein should belong to Non-specific_endonuclease that shares evolutionary origin and functional similarity; 3. The protein should be classified within DNA/RNA_non-sp_Endonuclease_sf, His-Me_finger_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MSSFFLSISPLVLALFHVVVQVCSQSCQVAISELQSERKVIILNSDKRSLKQPSNGKYSWKSGESIYFICGKDLKTLTCSPSSINAKRFDCVKPPDVTERDINRECNGKSSKTFQMGFRASGGLFVPYYELCYLMDTCSVSHVKHRLLGASFGGVSGTREKSFQSFVCPGLRYNTHYTQASQKQPDPRFYFQRGHLFPDRDAPVFAWKLATYSYGNCVPQWNTINSEGGNWWTLEYLVFKYAQQTPNTEYTIYDGVLYDPRNKQYLAKQEKKIEIPVWFWKVVTNQTHVLKVFFVSHNLKGTKQTFCNTNRCVNDRAKGTKTVETWDFYNEASRGITHCCYWKDLARKNPLPIEVQREINNKKN" }, { "InterPro": [ { "InterPro-ID": "IPR000524", "InterPro-Name": "Tscrpt_reg_HTH_GntR", "InterPro-Type": "DOMAIN", "Beg": 22, "End": 81 }, { "InterPro-ID": "IPR036390", "InterPro-Name": "WH_DNA-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 11, "End": 91 }, { "InterPro-ID": "IPR000524", "InterPro-Name": "Tscrpt_reg_HTH_GntR", "InterPro-Type": "DOMAIN", "Beg": 17, "End": 81 }, { "InterPro-ID": "IPR036388", "InterPro-Name": "WH-like_DNA-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 15, "End": 121 }, { "InterPro-ID": "IPR000524", "InterPro-Name": "Tscrpt_reg_HTH_GntR", "InterPro-Type": "DOMAIN", "Beg": 21, "End": 81 }, { "InterPro-ID": "IPR000524", "InterPro-Name": "Tscrpt_reg_HTH_GntR", "InterPro-Type": "DOMAIN", "Beg": 16, "End": 84 } ], "response#1": "MTELGDWVSIDPDSDKPLFDQLRVQIIDGIRDGRLSPGTRLPTVRELATHVGLAVNTVARSYRELEAAGVLETRGRFGTFVARADPADAAMAAAANSFAEAARSLGISRDDALRYIESALD", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Tscrpt_reg_HTH_GntR, Tscrpt_reg_HTH_GntR, Tscrpt_reg_HTH_GntR, Tscrpt_reg_HTH_GntR that are essential for its biological function; 2. The protein should be classified within WH_DNA-bd_sf, WH-like_DNA-bd_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MTELGDWVSIDPDSDKPLFDQLRVQIIDGIRDGRLSPGTRLPTVRELATHVGLAVNTVARSYRELEAAGVLETRGRFGTFVARADPADAAMAAAANSFAEAARSLGISRDDALRYIESALD" }, { "InterPro": [ { "InterPro-ID": "IPR009057", "InterPro-Name": "Homeodomain-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 23, "End": 107 }, { "InterPro-ID": "IPR050109", "InterPro-Name": "HTH-type_TetR-like_transc_reg", "InterPro-Type": "FAMILY", "Beg": 20, "End": 215 }, { "InterPro-ID": "IPR001647", "InterPro-Name": "HTH_TetR", "InterPro-Type": "DOMAIN", "Beg": 29, "End": 89 }, { "InterPro-ID": "IPR054129", "InterPro-Name": "DesT_TetR_C", "InterPro-Type": "DOMAIN", "Beg": 104, "End": 209 }, { "InterPro-ID": "IPR001647", "InterPro-Name": "HTH_TetR", "InterPro-Type": "DOMAIN", "Beg": 35, "End": 48 }, { "InterPro-ID": "IPR001647", "InterPro-Name": "HTH_TetR", "InterPro-Type": "DOMAIN", "Beg": 56, "End": 79 }, { "InterPro-ID": "IPR036271", "InterPro-Name": "Tet_transcr_reg_TetR-rel_C_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 101, "End": 213 }, { "InterPro-ID": "IPR001647", "InterPro-Name": "HTH_TetR", "InterPro-Type": "DOMAIN", "Beg": 36, "End": 81 } ], "response#1": "MSDLANTAERRGEKRPAGGNRRGNRLPRDERRGQLLIAASEVFVDRGYHAAGMDEIADRAGVSKPVLYQHFSSKLELYLAVLQRHVDNLVSGVRQALRTTTDNRQRLRAAVEAFFDFIEHDSQGYRLIFENDYVTEPQVAAQVKVATEACTDAVFDLISRDSGLEAHRARMIAVGLVAISVDSARYWLNNDRPIDKDSAVEGTVQFAWGGLSHVPLTRS", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more HTH_TetR, DesT_TetR_C, HTH_TetR, HTH_TetR, HTH_TetR that are essential for its biological function; 2. The protein should belong to HTH-type_TetR-like_transc_reg that shares evolutionary origin and functional similarity; 3. The protein should be classified within Homeodomain-like_sf, Tet_transcr_reg_TetR-rel_C_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MSDLANTAERRGEKRPAGGNRRGNRLPRDERRGQLLIAASEVFVDRGYHAAGMDEIADRAGVSKPVLYQHFSSKLELYLAVLQRHVDNLVSGVRQALRTTTDNRQRLRAAVEAFFDFIEHDSQGYRLIFENDYVTEPQVAAQVKVATEACTDAVFDLISRDSGLEAHRARMIAVGLVAISVDSARYWLNNDRPIDKDSAVEGTVQFAWGGLSHVPLTRS" }, { "InterPro": [ { "InterPro-ID": "IPR044720", "InterPro-Name": "HVO_2753-like", "InterPro-Type": "FAMILY", "Beg": 3, "End": 62 }, { "InterPro-ID": "IPR011668", "InterPro-Name": "HVO_2753-like_ZBP", "InterPro-Type": "DOMAIN", "Beg": 13, "End": 58 } ], "response#1": "MFAVEMKFEVPVCTSCGKEITPREHATHFVCPNCGEAIIWRCESCRVLSVPYKCPKCGWEGP", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more HVO_2753-like_ZBP that are essential for its biological function; 2. The protein should belong to HVO_2753-like that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MFAVEMKFEVPVCTSCGKEITPREHATHFVCPNCGEAIIWRCESCRVLSVPYKCPKCGWEGP" }, { "InterPro": [ { "InterPro-ID": "IPR036574", "InterPro-Name": "Scorpion_toxin-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1, "End": 66 }, { "InterPro-ID": "IPR044062", "InterPro-Name": "LCN-type_CS_alpha_beta_dom", "InterPro-Type": "DOMAIN", "Beg": 1, "End": 66 }, { "InterPro-ID": "IPR018218", "InterPro-Name": "Scorpion_toxinL", "InterPro-Type": "FAMILY", "Beg": 11, "End": 18 }, { "InterPro-ID": "IPR018218", "InterPro-Name": "Scorpion_toxinL", "InterPro-Type": "FAMILY", "Beg": 35, "End": 45 }, { "InterPro-ID": "IPR018218", "InterPro-Name": "Scorpion_toxinL", "InterPro-Type": "FAMILY", "Beg": 22, "End": 29 }, { "InterPro-ID": "IPR018218", "InterPro-Name": "Scorpion_toxinL", "InterPro-Type": "FAMILY", "Beg": 45, "End": 58 }, { "InterPro-ID": "IPR003614", "InterPro-Name": "Scorpion_toxin-like", "InterPro-Type": "DOMAIN", "Beg": 1, "End": 51 } ], "response#1": "KEGYIVNLSTGCKYECYKLGDNDYCLKECKLQYGKGAGGYCYAFGCWCTHLYEQAVVWPLPKKTCN", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more LCN-type_CS_alpha_beta_dom, Scorpion_toxin-like that are essential for its biological function; 2. The protein should belong to Scorpion_toxinL, Scorpion_toxinL, Scorpion_toxinL, Scorpion_toxinL that shares evolutionary origin and functional similarity; 3. The protein should be classified within Scorpion_toxin-like_sf sharing conserved structural features. The designed protein sequence is ", "reference": "KEGYIVNLSTGCKYECYKLGDNDYCLKECKLQYGKGAGGYCYAFGCWCTHLYEQAVVWPLPKKTCN" }, { "InterPro": [ { "InterPro-ID": "IPR003614", "InterPro-Name": "Scorpion_toxin-like", "InterPro-Type": "DOMAIN", "Beg": 1, "End": 51 }, { "InterPro-ID": "IPR044062", "InterPro-Name": "LCN-type_CS_alpha_beta_dom", "InterPro-Type": "DOMAIN", "Beg": 1, "End": 66 }, { "InterPro-ID": "IPR036574", "InterPro-Name": "Scorpion_toxin-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1, "End": 66 }, { "InterPro-ID": "IPR018218", "InterPro-Name": "Scorpion_toxinL", "InterPro-Type": "FAMILY", "Beg": 11, "End": 18 }, { "InterPro-ID": "IPR018218", "InterPro-Name": "Scorpion_toxinL", "InterPro-Type": "FAMILY", "Beg": 35, "End": 45 }, { "InterPro-ID": "IPR018218", "InterPro-Name": "Scorpion_toxinL", "InterPro-Type": "FAMILY", "Beg": 45, "End": 58 }, { "InterPro-ID": "IPR018218", "InterPro-Name": "Scorpion_toxinL", "InterPro-Type": "FAMILY", "Beg": 22, "End": 29 } ], "response#1": "KEGYIVNHSTGCKYECYKLGDNDYCLRECKLQYGKGAGGYCYAFGCWCTHLYEQAVVWPLPKKTCN", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Scorpion_toxin-like, LCN-type_CS_alpha_beta_dom that are essential for its biological function; 2. The protein should belong to Scorpion_toxinL, Scorpion_toxinL, Scorpion_toxinL, Scorpion_toxinL that shares evolutionary origin and functional similarity; 3. The protein should be classified within Scorpion_toxin-like_sf sharing conserved structural features. The designed protein sequence is ", "reference": "KEGYIVNHSTGCKYECYKLGDNDYCLRECKLQYGKGAGGYCYAFGCWCTHLYEQAVVWPLPKKTCN" }, { "InterPro": [ { "InterPro-ID": "IPR018218", "InterPro-Name": "Scorpion_toxinL", "InterPro-Type": "FAMILY", "Beg": 11, "End": 18 }, { "InterPro-ID": "IPR018218", "InterPro-Name": "Scorpion_toxinL", "InterPro-Type": "FAMILY", "Beg": 35, "End": 45 }, { "InterPro-ID": "IPR018218", "InterPro-Name": "Scorpion_toxinL", "InterPro-Type": "FAMILY", "Beg": 45, "End": 58 }, { "InterPro-ID": "IPR018218", "InterPro-Name": "Scorpion_toxinL", "InterPro-Type": "FAMILY", "Beg": 22, "End": 29 }, { "InterPro-ID": "IPR044062", "InterPro-Name": "LCN-type_CS_alpha_beta_dom", "InterPro-Type": "DOMAIN", "Beg": 1, "End": 66 }, { "InterPro-ID": "IPR036574", "InterPro-Name": "Scorpion_toxin-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1, "End": 66 }, { "InterPro-ID": "IPR003614", "InterPro-Name": "Scorpion_toxin-like", "InterPro-Type": "DOMAIN", "Beg": 1, "End": 51 } ], "response#1": "KEGYIVNYYDGCKYACVKLGDNDYCLRECRLRYYKSAGGYCYAFACWCTHLYEQAVVWPLPNKTCN", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more LCN-type_CS_alpha_beta_dom, Scorpion_toxin-like that are essential for its biological function; 2. The protein should belong to Scorpion_toxinL, Scorpion_toxinL, Scorpion_toxinL, Scorpion_toxinL that shares evolutionary origin and functional similarity; 3. The protein should be classified within Scorpion_toxin-like_sf sharing conserved structural features. The designed protein sequence is ", "reference": "KEGYIVNYYDGCKYACVKLGDNDYCLRECRLRYYKSAGGYCYAFACWCTHLYEQAVVWPLPNKTCN" }, { "InterPro": [ { "InterPro-ID": "IPR007109", "InterPro-Name": "Brix", "InterPro-Type": "DOMAIN", "Beg": 35, "End": 259 }, { "InterPro-ID": "IPR039770", "InterPro-Name": "Rpf2", "InterPro-Type": "FAMILY", "Beg": 1, "End": 343 }, { "InterPro-ID": "IPR007109", "InterPro-Name": "Brix", "InterPro-Type": "DOMAIN", "Beg": 31, "End": 260 }, { "InterPro-ID": "IPR007109", "InterPro-Name": "Brix", "InterPro-Type": "DOMAIN", "Beg": 28, "End": 266 } ], "response#1": "MLRQIKPRNARSKRALEKRAPKIVENPKTCLFLRGTTCSQITQDAMNDLYAMRQVHAKRFHKKNAIHPFEDATSLCFFSEKNDCSLMVFGSSNKKRPHTLTFVRMFDYKVLDMLEFYLDPDTYRSISQFKTSKIPIGMRPMMVFAGTAFESPVPNAFTMAKSMLIDFFRGEPSDKIDVEGLRFVVVVTADEPTSSTSTNNDGENPAPLPGMTDPRSIDPSQKPILRLRVYGIRTKRSGTRLPRVEVEEHGPRMDFRLGRMREPDPAMLKEAMKKAKTPQEERTKKNISMDLLGDKIGRIHMGKTDLSKLQTRKMKGLKRGRDEDEGGEDDRTDVVEAGSGEKKKKKKVKG", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Brix, Brix, Brix that are essential for its biological function; 2. The protein should belong to Rpf2 that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MLRQIKPRNARSKRALEKRAPKIVENPKTCLFLRGTTCSQITQDAMNDLYAMRQVHAKRFHKKNAIHPFEDATSLCFFSEKNDCSLMVFGSSNKKRPHTLTFVRMFDYKVLDMLEFYLDPDTYRSISQFKTSKIPIGMRPMMVFAGTAFESPVPNAFTMAKSMLIDFFRGEPSDKIDVEGLRFVVVVTADEPTSSTSTNNDGENPAPLPGMTDPRSIDPSQKPILRLRVYGIRTKRSGTRLPRVEVEEHGPRMDFRLGRMREPDPAMLKEAMKKAKTPQEERTKKNISMDLLGDKIGRIHMGKTDLSKLQTRKMKGLKRGRDEDEGGEDDRTDVVEAGSGEKKKKKKVKG" }, { "InterPro": [ { "InterPro-ID": "IPR044062", "InterPro-Name": "LCN-type_CS_alpha_beta_dom", "InterPro-Type": "DOMAIN", "Beg": 1, "End": 66 }, { "InterPro-ID": "IPR003614", "InterPro-Name": "Scorpion_toxin-like", "InterPro-Type": "DOMAIN", "Beg": 1, "End": 51 }, { "InterPro-ID": "IPR018218", "InterPro-Name": "Scorpion_toxinL", "InterPro-Type": "FAMILY", "Beg": 11, "End": 18 }, { "InterPro-ID": "IPR018218", "InterPro-Name": "Scorpion_toxinL", "InterPro-Type": "FAMILY", "Beg": 35, "End": 45 }, { "InterPro-ID": "IPR018218", "InterPro-Name": "Scorpion_toxinL", "InterPro-Type": "FAMILY", "Beg": 45, "End": 58 }, { "InterPro-ID": "IPR018218", "InterPro-Name": "Scorpion_toxinL", "InterPro-Type": "FAMILY", "Beg": 22, "End": 29 }, { "InterPro-ID": "IPR036574", "InterPro-Name": "Scorpion_toxin-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1, "End": 66 } ], "response#1": "KEGYIVNYHDGCKYACVKLGDNDYCLRECRLRYYKSAGGYCYAFACWCTHLYEQAVVWPLPNKTCN", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more LCN-type_CS_alpha_beta_dom, Scorpion_toxin-like that are essential for its biological function; 2. The protein should belong to Scorpion_toxinL, Scorpion_toxinL, Scorpion_toxinL, Scorpion_toxinL that shares evolutionary origin and functional similarity; 3. The protein should be classified within Scorpion_toxin-like_sf sharing conserved structural features. The designed protein sequence is ", "reference": "KEGYIVNYHDGCKYACVKLGDNDYCLRECRLRYYKSAGGYCYAFACWCTHLYEQAVVWPLPNKTCN" }, { "InterPro": [ { "InterPro-ID": "IPR012674", "InterPro-Name": "Calycin", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 24, "End": 165 }, { "InterPro-ID": "IPR012674", "InterPro-Name": "Calycin", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 19, "End": 163 }, { "InterPro-ID": "IPR005657", "InterPro-Name": "Triabi/Procalin", "InterPro-Type": "FAMILY", "Beg": 20, "End": 156 } ], "response#1": "MKTIIVVTIFGILTCAYPTDGEHCAQEKAMEDFDPSRFFNGKWYVVHYGKTGPTVCQKFSTNGTQGAPTQIVETGYDKFEDYLKFQCDETGKKNDYHYSFKCKSYECGSDNIEFEVDFTVLSASYDDFALVCRTITFTSGTKDKDDEVLVLEREKTLDVIDNCRRTYYLTEFEKMSLSSQFLSKKENITMLSFQLK", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Triabi/Procalin that shares evolutionary origin and functional similarity; 2. The protein should be classified within Calycin, Calycin sharing conserved structural features. The designed protein sequence is ", "reference": "MKTIIVVTIFGILTCAYPTDGEHCAQEKAMEDFDPSRFFNGKWYVVHYGKTGPTVCQKFSTNGTQGAPTQIVETGYDKFEDYLKFQCDETGKKNDYHYSFKCKSYECGSDNIEFEVDFTVLSASYDDFALVCRTITFTSGTKDKDDEVLVLEREKTLDVIDNCRRTYYLTEFEKMSLSSQFLSKKENITMLSFQLK" }, { "InterPro": [ { "InterPro-ID": "IPR036736", "InterPro-Name": "ACP-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 3634, "End": 3732 }, { "InterPro-ID": "IPR036736", "InterPro-Name": "ACP-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 2053, "End": 2152 }, { "InterPro-ID": "IPR036736", "InterPro-Name": "ACP-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 5390, "End": 5487 }, { "InterPro-ID": "IPR049552", "InterPro-Name": "PKS_DH_N", "InterPro-Type": "DOMAIN", "Beg": 976, "End": 1077 }, { "InterPro-ID": "IPR049552", "InterPro-Name": "PKS_DH_N", "InterPro-Type": "DOMAIN", "Beg": 4649, "End": 4749 }, { "InterPro-ID": "IPR050091", "InterPro-Name": "PKS_NRPS_Biosynth_Enz", "InterPro-Type": "FAMILY", "Beg": 1335, "End": 2144 }, { "InterPro-ID": "IPR016039", "InterPro-Name": "Thiolase-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 2158, "End": 2609 }, { "InterPro-ID": "IPR016039", "InterPro-Name": "Thiolase-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 3741, "End": 4192 }, { "InterPro-ID": "IPR016039", "InterPro-Name": "Thiolase-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 49, "End": 492 }, { "InterPro-ID": "IPR036291", "InterPro-Name": "NAD(P)-bd_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1577, "End": 1748 }, { "InterPro-ID": "IPR009081", "InterPro-Name": "PP-bd_ACP", "InterPro-Type": "DOMAIN", "Beg": 3658, "End": 3724 }, { "InterPro-ID": "IPR009081", "InterPro-Name": "PP-bd_ACP", "InterPro-Type": "DOMAIN", "Beg": 5416, "End": 5481 }, { "InterPro-ID": "IPR009081", "InterPro-Name": "PP-bd_ACP", "InterPro-Type": "DOMAIN", "Beg": 2078, "End": 2144 }, { "InterPro-ID": "IPR036291", "InterPro-Name": "NAD(P)-bd_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 4935, "End": 5117 }, { "InterPro-ID": "IPR016036", "InterPro-Name": "Malonyl_transacylase_ACP-bd", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 735, "End": 800 }, { "InterPro-ID": "IPR020841", "InterPro-Name": "PKS_Beta-ketoAc_synthase_dom", "InterPro-Type": "DOMAIN", "Beg": 3746, "End": 4172 }, { "InterPro-ID": "IPR009081", "InterPro-Name": "PP-bd_ACP", "InterPro-Type": "DOMAIN", "Beg": 5410, "End": 5485 }, { "InterPro-ID": "IPR001227", "InterPro-Name": "Ac_transferase_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 4278, "End": 4584 }, { "InterPro-ID": "IPR001227", "InterPro-Name": "Ac_transferase_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 2708, "End": 3019 }, { "InterPro-ID": "IPR001227", "InterPro-Name": "Ac_transferase_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 610, "End": 913 }, { "InterPro-ID": "IPR006162", "InterPro-Name": "Ppantetheine_attach_site", "InterPro-Type": "PTM", "Beg": 2103, "End": 2118 }, { "InterPro-ID": "IPR036291", "InterPro-Name": "NAD(P)-bd_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 3130, "End": 3357 }, { "InterPro-ID": "IPR020841", "InterPro-Name": "PKS_Beta-ketoAc_synthase_dom", "InterPro-Type": "DOMAIN", "Beg": 60, "End": 486 }, { "InterPro-ID": "IPR020841", "InterPro-Name": "PKS_Beta-ketoAc_synthase_dom", "InterPro-Type": "DOMAIN", "Beg": 2170, "End": 2596 }, { "InterPro-ID": "IPR020841", "InterPro-Name": "PKS_Beta-ketoAc_synthase_dom", "InterPro-Type": "DOMAIN", "Beg": 3749, "End": 4175 }, { "InterPro-ID": "IPR055123", "InterPro-Name": "SpnB-like_Rossmann", "InterPro-Type": "DOMAIN", "Beg": 1281, "End": 1437 }, { "InterPro-ID": "IPR055123", "InterPro-Name": "SpnB-like_Rossmann", "InterPro-Type": "DOMAIN", "Beg": 5007, "End": 5113 }, { "InterPro-ID": "IPR049900", "InterPro-Name": "PKS_mFAS_DH", "InterPro-Type": "DOMAIN", "Beg": 976, "End": 1264 }, { "InterPro-ID": "IPR011032", "InterPro-Name": "GroES-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1489, "End": 1610 }, { "InterPro-ID": "IPR042104", "InterPro-Name": "PKS_dehydratase_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 965, "End": 1265 }, { "InterPro-ID": "IPR042104", "InterPro-Name": "PKS_dehydratase_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 4638, "End": 4933 }, { "InterPro-ID": "IPR016039", "InterPro-Name": "Thiolase-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 2164, "End": 2540 }, { "InterPro-ID": "IPR016035", "InterPro-Name": "Acyl_Trfase/lysoPLipase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 608, "End": 902 }, { "InterPro-ID": "IPR020843", "InterPro-Name": "PKS_ER", "InterPro-Type": "DOMAIN", "Beg": 1478, "End": 1777 }, { "InterPro-ID": "IPR014030", "InterPro-Name": "Ketoacyl_synth_N", "InterPro-Type": "DOMAIN", "Beg": 58, "End": 308 }, { "InterPro-ID": "IPR014030", "InterPro-Name": "Ketoacyl_synth_N", "InterPro-Type": "DOMAIN", "Beg": 3747, "End": 3997 }, { "InterPro-ID": "IPR014030", "InterPro-Name": "Ketoacyl_synth_N", "InterPro-Type": "DOMAIN", "Beg": 2168, "End": 2418 }, { "InterPro-ID": "IPR036291", "InterPro-Name": "NAD(P)-bd_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 3373, "End": 3611 }, { "InterPro-ID": "IPR013154", "InterPro-Name": "ADH-like_N", "InterPro-Type": "DOMAIN", "Beg": 1497, "End": 1574 }, { "InterPro-ID": "IPR006162", "InterPro-Name": "Ppantetheine_attach_site", "InterPro-Type": "PTM", "Beg": 3683, "End": 3698 }, { "InterPro-ID": "IPR016035", "InterPro-Name": "Acyl_Trfase/lysoPLipase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 4277, "End": 4563 }, { "InterPro-ID": "IPR020841", "InterPro-Name": "PKS_Beta-ketoAc_synthase_dom", "InterPro-Type": "DOMAIN", "Beg": 2167, "End": 2593 }, { "InterPro-ID": "IPR036291", "InterPro-Name": "NAD(P)-bd_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1268, "End": 1442 }, { "InterPro-ID": "IPR014043", "InterPro-Name": "Acyl_transferase_dom", "InterPro-Type": "DOMAIN", "Beg": 2710, "End": 3015 }, { "InterPro-ID": "IPR014043", "InterPro-Name": "Acyl_transferase_dom", "InterPro-Type": "DOMAIN", "Beg": 612, "End": 910 }, { "InterPro-ID": "IPR014043", "InterPro-Name": "Acyl_transferase_dom", "InterPro-Type": "DOMAIN", "Beg": 4280, "End": 4581 }, { "InterPro-ID": "IPR016035", "InterPro-Name": "Acyl_Trfase/lysoPLipase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 2707, "End": 3005 }, { "InterPro-ID": "IPR041618", "InterPro-Name": "PKS_DE", "InterPro-Type": "DOMAIN", "Beg": 3084, "End": 3125 }, { "InterPro-ID": "IPR049551", "InterPro-Name": "PKS_DH_C", "InterPro-Type": "DOMAIN", "Beg": 1111, "End": 1261 }, { "InterPro-ID": "IPR049551", "InterPro-Name": "PKS_DH_C", "InterPro-Type": "DOMAIN", "Beg": 4780, "End": 4930 }, { "InterPro-ID": "IPR018201", "InterPro-Name": "Ketoacyl_synth_AS", "InterPro-Type": "ACTIVE_SITE", "Beg": 221, "End": 237 }, { "InterPro-ID": "IPR049900", "InterPro-Name": "PKS_mFAS_DH", "InterPro-Type": "DOMAIN", "Beg": 4649, "End": 4931 }, { "InterPro-ID": "IPR009081", "InterPro-Name": "PP-bd_ACP", "InterPro-Type": "DOMAIN", "Beg": 2073, "End": 2148 }, { "InterPro-ID": "IPR009081", "InterPro-Name": "PP-bd_ACP", "InterPro-Type": "DOMAIN", "Beg": 3653, "End": 3728 }, { "InterPro-ID": "IPR020841", "InterPro-Name": "PKS_Beta-ketoAc_synthase_dom", "InterPro-Type": "DOMAIN", "Beg": 57, "End": 483 }, { "InterPro-ID": "IPR014031", "InterPro-Name": "Ketoacyl_synth_C", "InterPro-Type": "DOMAIN", "Beg": 2426, "End": 2543 }, { "InterPro-ID": "IPR014031", "InterPro-Name": "Ketoacyl_synth_C", "InterPro-Type": "DOMAIN", "Beg": 4005, "End": 4122 }, { "InterPro-ID": "IPR014031", "InterPro-Name": "Ketoacyl_synth_C", "InterPro-Type": "DOMAIN", "Beg": 316, "End": 433 }, { "InterPro-ID": "IPR036736", "InterPro-Name": "ACP-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 2074, "End": 2182 }, { "InterPro-ID": "IPR036291", "InterPro-Name": "NAD(P)-bd_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1785, "End": 1993 }, { "InterPro-ID": "IPR020806", "InterPro-Name": "PKS_PP-bd", "InterPro-Type": "DOMAIN", "Beg": 5413, "End": 5485 }, { "InterPro-ID": "IPR020806", "InterPro-Name": "PKS_PP-bd", "InterPro-Type": "DOMAIN", "Beg": 2076, "End": 2148 }, { "InterPro-ID": "IPR020806", "InterPro-Name": "PKS_PP-bd", "InterPro-Type": "DOMAIN", "Beg": 3656, "End": 3728 }, { "InterPro-ID": "IPR016036", "InterPro-Name": "Malonyl_transacylase_ACP-bd", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 4402, "End": 4467 }, { "InterPro-ID": "IPR013968", "InterPro-Name": "PKS_KR", "InterPro-Type": "DOMAIN", "Beg": 3373, "End": 3551 }, { "InterPro-ID": "IPR013968", "InterPro-Name": "PKS_KR", "InterPro-Type": "DOMAIN", "Beg": 5134, "End": 5306 }, { "InterPro-ID": "IPR013968", "InterPro-Name": "PKS_KR", "InterPro-Type": "DOMAIN", "Beg": 1787, "End": 1966 }, { "InterPro-ID": "IPR036736", "InterPro-Name": "ACP-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 3650, "End": 3762 }, { "InterPro-ID": "IPR016039", "InterPro-Name": "Thiolase-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 55, "End": 431 }, { "InterPro-ID": "IPR016039", "InterPro-Name": "Thiolase-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 3745, "End": 4121 }, { "InterPro-ID": "IPR016036", "InterPro-Name": "Malonyl_transacylase_ACP-bd", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 2842, "End": 2907 }, { "InterPro-ID": "IPR032821", "InterPro-Name": "PKS_assoc", "InterPro-Type": "DOMAIN", "Beg": 2546, "End": 2672 }, { "InterPro-ID": "IPR032821", "InterPro-Name": "PKS_assoc", "InterPro-Type": "DOMAIN", "Beg": 436, "End": 548 }, { "InterPro-ID": "IPR032821", "InterPro-Name": "PKS_assoc", "InterPro-Type": "DOMAIN", "Beg": 4125, "End": 4243 }, { "InterPro-ID": "IPR014043", "InterPro-Name": "Acyl_transferase_dom", "InterPro-Type": "DOMAIN", "Beg": 4279, "End": 4601 }, { "InterPro-ID": "IPR014043", "InterPro-Name": "Acyl_transferase_dom", "InterPro-Type": "DOMAIN", "Beg": 611, "End": 926 }, { "InterPro-ID": "IPR014043", "InterPro-Name": "Acyl_transferase_dom", "InterPro-Type": "DOMAIN", "Beg": 2710, "End": 3016 }, { "InterPro-ID": "IPR036736", "InterPro-Name": "ACP-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 5408, "End": 5488 }, { "InterPro-ID": "IPR036299", "InterPro-Name": "Polyketide_synth_docking_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 27, "End": 58 }, { "InterPro-ID": "IPR015083", "InterPro-Name": "NorB/c/GfsB-D-like_docking", "InterPro-Type": "DOMAIN", "Beg": 27, "End": 54 }, { "InterPro-ID": "IPR018201", "InterPro-Name": "Ketoacyl_synth_AS", "InterPro-Type": "ACTIVE_SITE", "Beg": 3910, "End": 3926 }, { "InterPro-ID": "IPR020807", "InterPro-Name": "PKS_DH", "InterPro-Type": "DOMAIN", "Beg": 4649, "End": 4813 }, { "InterPro-ID": "IPR020807", "InterPro-Name": "PKS_DH", "InterPro-Type": "DOMAIN", "Beg": 976, "End": 1148 }, { "InterPro-ID": "IPR002364", "InterPro-Name": "Quin_OxRdtase/zeta-crystal_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 1605, "End": 1626 }, { "InterPro-ID": "IPR018201", "InterPro-Name": "Ketoacyl_synth_AS", "InterPro-Type": "ACTIVE_SITE", "Beg": 2331, "End": 2347 }, { "InterPro-ID": "IPR006162", "InterPro-Name": "Ppantetheine_attach_site", "InterPro-Type": "PTM", "Beg": 5440, "End": 5455 }, { "InterPro-ID": "IPR036291", "InterPro-Name": "NAD(P)-bd_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 5128, "End": 5363 } ], "response#1": "MSVPPPGATPSRTSRTKGLKDRPRMENEEKLVEYLKRATTDLRQARRRLREVEDQQQEPVAIIGMSCRYPGDVHSPDDLWRMVADGDDGISTFPAERGWDVERLYDPDPDRPGTTYTTRGGFLHDAHLFDAEFFGISPREALATDPQQRLLLETSWEAFERAGIDPTSLRGSHTGVFAGVMYQDYAHRVRPVPEEFEGYLGNGSAGSIASGRVAYTFGLEGPAVTVDTACSSSLVALHLAVQSLRQGDSTLALAGGVAIMSTPDVFVEYSRQRGLAADGRCKAFAEAADGTGWAEGVGMLLLERLSDARRNGHPVLAVVRGSAVNQDGASSRLTAPNGPSQQRVIRQALANARLTPADVDVVEAHGTGTKLGDPIEAQALLATYGQDRPAERPLWLGSLKSNIGHTQAAAGVGGVIKMVMAIRHGVAPRTLHVDRPTPEVDWSAGAVELLTEARPWPETDRPRRAGVSAFGVSGTNAHVIIEQPPAIEGTGLGDDAPPTAEHPEERTPADGGPAPQPVAWPLSAKSPEALRDQARQLRHHLTSGATASALSHPLADIGHSLATTRTAFDHRVVVLGTDHDALLRSLAALADGGTDPSVVQGSVRGRGRVAFVFPGQGSQWEGMARELLDTSPVFARQMQACADALSAYVDWSLHDVLRGAPDAPGLDRVDVVQPVLWAIMISLSELWRAHGVQPSAVVGHSQGEIAAAYVAGALSLDDSARVVALRSKALRALSGKGGMLSVPLSEEDLTPQLAAHTGQLSIAAVNGPGSVVVSGDADALEGLFEELTAAGVRARKVAVDYASHSAHVEALREELLTRLGPVAPRPAKVPFYSTVTGERLAGTEALDADYWYRNLRETVRFEQATRALLAQNIGVFVETGPHPVLAVGLQETIDATGGSAVALGSLRRGEGGPDRFLRSLAEAYAHGAPLDWDLLFPGARRVELPTYAFQRDHYWLQIPEGGPADAAGLGLAAVEHPLLAAATSLADGDGLIVTGRLSTRSLPWLADHAVTGTVLLPGTAFVELALRAADLTDCHLLDELTLHTPLVVPDDDPVRVQVRVAAPDPATGRRALTVHARPESPDGDADQEEQGAEWTLHATGYLAVGAHEPAVPDQGQWPPAGATPLDVTDLYPRLADAGYGYGLAFQGLRAAWRLGDDVYAEAELPDEHSDQAGRYGLHPALLDAALHAAGFAGFPDGDGALPGPRLPFSWTGVTLSAVGARALRIRLARTGDDTLTVTLTDPAGEPVATVESLALRPLATNQAPRTPSDLHRVAYTPRDLPADASTAHWAVLDADDLAYALNLPSHPDRDALAALDPAPPVVLTGWPVPDDPAPQAARTVLARALHDIQDWLADDRLADTRLVVVTHNALPADDWQDTDPVAASLTGLLRTAQSENPGRLVLIDTDGHPASWQALPALVATGEPQAALRLGEARVPRLAPAATDAALSVPAAVPAATDASLPVPADTSAWRLAVESPGTLDHLTLIPWAAATAPLEEGQVRIAVRTCGVNFRDVLIALGMYPDPDMLGSEGAGRVVEVGPGVTDLAVGDRVAGILAGGFGPLAVIDAPKVARIPDSWTWEQAASVPLAFATAWYALVDLAALAPGEKVLVHAAAGGVGMAAVQIARHLGAEVYATASPAKWDTLRALGLDDDHIASSRDTAFAEKFPAVDVVLDSLAGEFVDASLRLLPHGGRFVEMGKTDRRDPERIAADHPGVHYRAFDLRESGDRRLREMLDEIFALVEDGTLHPLPYRSWDLRRAPEAFRHMQQARHIGKIVLTVPPALDPDGTVLVTGATGTLGALVTRHLVTEHGVRRLLLVSRSGPQAPGADALLADLAAAGAEATLTACDTADRDQLRAVLDAVPADHPLTAVIHTAGALDDGVLSALTPERLDAVLRPKADAAWHLHELTAGHDLAAFVLFSSAAGLFGNAGQGNYAAANAFLDALAQHRRALGLPATSLAWGLWEERGGMTGHLDTADVGRLSRTGVATLDSAHGLALFDAALSTGQTLLVPLPLDRAALHRQARTGSLPALLSGLVRTTPARRTATGTAATGSVGDTLARRLTAAAPADRDRIVNDLVRDHAAAVLGHGSATAVGLGRAFRDLGFDSLTAVELRNRLGAATGLRLPATLVFDHPTPEELAAHLRDTLLGAADSGAAAVVTTSAEADEPLAVVAMSCRFPGGTGSPEELWELLADGGDAIGALPADRGWDLAGLYHPDPDQPGTSYARHGGFLHDAGDFDASLFGISPREALAMDPQQRLLLETSWEAFERAGLDLRTLRGSRTGVYVGALPSSYGGTLHDAPDGLEGHLMTGNSTSIVSGRLAYTFGLQGPAVTVDTACSSSLVALHLAVQALRSGEVTMALVGGATVMSNPGGLIAFSRQRGLAADGRCKAFSAAADGMGMAEGVGMLLVERLSDAERLGHPVLAVVRGSAINQDGASNGLTAPNGPSQQRVIRDALADARLNASEVDVVEAHGTGTKLGDPIEAQALLATYGQDRPEERPVLLGSVKSNIGHTQAAAGVAGVIKMVLAMRHGLLPRTLHVDEPSTQIDWNAGALSLLAEETPWPETGRPRRAAVSSFGISGTNAHVILEQAPASVPAPASASVPGDSGEAPDPVVVPWVVSGRSADALRAQAGQLAAWADSAAGRDTEPVDVGRALATARSFLEHRAVVVGGDRAELVEALRALATDPAAGSTAADPDGPGGRLGLVFSGQGSQRPGMGRELYTAYPVFAAALDEVCGVLDEVMGAQPPSEGWTGSLREVMFEVSSDLLDETGFTQPALFAFEVALYRLLESWGVAGEVVAGHSVGEIAAAHVAGVLSLADACALVAARGRLMQALPSGGAMVAVEASEEEVAAVLAGRGDEGAGIGAVNAPGSVVVSGVEAAVEEVAARFAGLGRRTRRLKVSHAFHSPLMDPMLAEFRRVVEGLSFAPPRMTVVSTLTGAVASDEELCSVDYWVRHARETVRFGDAVRCMAGAEVDRFAEVGPSGVLAGLVRASVTGEGTRAAVALQRGNRTEPGALVSALGELFVSGLPVDWATYFAGRPLRRVELPTYAFQRARYWLEGAAGAGGRQSAADGQDEVDAAFWEAVEHGDLSALGAGLDVDGEARLADVLPALSSWRRRAEQASVVDAWRYRVTWAPLPEPARASATGVWLLLVPAGAEDAADATRTVEGALAEHGGEVVKVDVAHPEADEARTALAQQITEQFIERFGVTEIGRLRGVVSLLALADGDDPRHPSVSRGLALTLGLVQALGDMELTAPLWCLTRGAVAVDASDGVDGAVQAQVWGLGRAVALEHPDRWGGLVDLPEYVDPRTARRLTGVLTGTGAGAGAGGLGREDQIALRATGAFGCRLTRDTVAPAGDPGEWTLSGTVLVTGGTGAVGGHVARWLAARGAERLVLVSRRGPRAPGADALRDELTAAGAQVEMLACDLSDGSAVTALVAGLAAGGDLTAVVHAAGVLDDGVLASLSVERCAEVLAAKARAAHHLDLATRDVNLDAFVLFSSVSGVLGAAGQANYAAANAHLDAVALHRHALGLPAVSVAWGPWAEGGMAGEDAAAGRLSRDGWTAMAPEPAATAMARAVAAGHPAVMIADVDWQRFAPAYAAVRPGNSLLTGVPEARQAQPQPWSADGERSAWASRLAGLPEEEQRTALLDLVRGQVASVLGHASMQTIDPARAFKEIGFDSLTAVELRNRLNAATGLALPATLVFDYPTPVALAEYVGSQVLGTSSPAVTGPLVVAAVDEPVAIIGMSCRFPGGVQSPEELWDLVVGGRDAISSFPTDRGWDVDALFDPDPEKPGKTYTRHGAFLHDAAEFDPRFFGISPREASAMDPQQRLLLETAWEAFERAGIDPAALRGSATGVFTGTNGQDYATRLRETPQGVEGYLMTGNAGSVISGRLAYTFGLEGPAMTVDTACSASLVALHLAAQALRQGECSLALAGGATVMSTPGAFVEFSRQGGLAADGRCKAFSASADGTGWGEGVGLLLLERLSDAERNGHPVLAVVRGSAVNQDGASNGLTAPNGPSQQRVIRQALANARLSASEVDVVEAHGTGTRLGDPIEAQALLATYGQDRPEDRPLWLGSVKSNLGHTQAAAGVAGIIKSVMAMRHGVLPATLHVDEPTSEVDWSAGAVELLTEARPWPEVGRPRRAAVSGFGVSGTNAHVILEQAAETGSTSEEGPAALVPTVVWPISGRDEQALRGQARRLRERLVVEPGLSAADVGLSLATTRSCFEQRAVVVGETRDELLAGLEALAEGREASGLVRGSARGSVNVGFLFSGQGSQRVGMGRELAERFPVFAGVFGEVCGLLDPLLPRPLGEVIAAGPGVLGRTVFTQPALFAVEVAAARLLLSWGVRPQVVAGHSVGEIAAAHVAGVLSLEDACALVAARGRLMEALPAGGVMVALEATEGEVAELLEAHAGAPVGVAAVNGPRAVVVSGDASPVGEIADVVRSWGRRTKRLEVSHAFHSPLMEPMLAEFTEVVSGLEFAAPQIGFVSAVTGGLVGADVVSRPEYWVEHVAQPVRFADAVRAAVDEAGVSLFVEVGPGGALSAMGPDCLDETVGDKQPVVFVPSLRADRPEPLAVTTALATAHVNGVQPDWQAVFAGTGAARVELPTYAFQRGRYWLDASVGGTGDASAVGLATLEHPLLAGVVDLAEEDRTVFTGRLSLTTHPWLADHAVFGSVLLPGTGFVELALAAGQYTGFGHLDELTVHAPLVLPARGAVHVQLVLDGVDDSGRRALTVHSRPEGVAGEQTWTRHATGALTVAEAVDPPAVSAVWPPAGAIEVELDDPYERFAAEGYAYGPAFQGLRRVWRGDGELFAEVELGAQELEAAGRFGVHPALLDAALHPLLLADGSTGQDGDTPTAGRLPFSWTGVSLRATGATTARVTLAFTDGDAVRITVADGDGGLVASVDALVTRPIAAGQLAAGRSGLFEVEWAPVSSSPAGSASWAVVGGGEAGVSAGGPGLGSYEDLAALRRAMDSGAPVPEVVFAHCGGGAEAADVVGGTHTATHAALVSLREWLADERFAGARLAIVTGGAVAVRPGDEVSDLAGAAVWGLVRSAQSEHPGQFVLVDTDGAAEPSSAAAALATGEPQVAVRGGEVFVPRLARADRTPAADSGVRWDPDKSLLVTGASGVLAGLVVRHAVAEWAVRHVVLVSRSGADGLAQELAEAGVSVQQARCDVADREAVAAVLAGIPAEHRLGGVIHTAGVLDDGVIESLTPERLAPVLRPKVDGAWWLHELTADVDLSVFAVFSSAAGVFGAAGQGNYAAANAFLDALALYRHREGLPATSLSWGLWAERSGMAGQLADAQLERLERTGVHPLSSSEGLALLDAALATGRPWLVPVGLDLGVMRAQADLGVTPLFRGLVRAPLRRAQVDKAASNAPDELRRELAVASAADRERMVLDLVRDRTAVVLGFGSRDEVGVDSGFTSMGVDSLAGVDLRNRLSSATGLRLPTTLIFDYPTPAALARYLHTHLVDDAVDQVDIRSVLAELDRLEATLAQVQAGDVGHMKIASRLQDLVGQWHGSGGATPGEDTVTDLEEATADEIFSFIDDNFGSTEVH", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more PKS_DH_N, PKS_DH_N, PP-bd_ACP, PP-bd_ACP, PP-bd_ACP, PKS_Beta-ketoAc_synthase_dom, PP-bd_ACP, PKS_Beta-ketoAc_synthase_dom, PKS_Beta-ketoAc_synthase_dom, PKS_Beta-ketoAc_synthase_dom, SpnB-like_Rossmann, SpnB-like_Rossmann, PKS_mFAS_DH, PKS_ER, Ketoacyl_synth_N, Ketoacyl_synth_N, Ketoacyl_synth_N, ADH-like_N, PKS_Beta-ketoAc_synthase_dom, Acyl_transferase_dom, Acyl_transferase_dom, Acyl_transferase_dom, PKS_DE, PKS_DH_C, PKS_DH_C, PKS_mFAS_DH, PP-bd_ACP, PP-bd_ACP, PKS_Beta-ketoAc_synthase_dom, Ketoacyl_synth_C, Ketoacyl_synth_C, Ketoacyl_synth_C, PKS_PP-bd, PKS_PP-bd, PKS_PP-bd, PKS_KR, PKS_KR, PKS_KR, PKS_assoc, PKS_assoc, PKS_assoc, Acyl_transferase_dom, Acyl_transferase_dom, Acyl_transferase_dom, NorB/c/GfsB-D-like_docking, PKS_DH, PKS_DH that are essential for its biological function; 2. The protein should belong to PKS_NRPS_Biosynth_Enz that shares evolutionary origin and functional similarity; 3. The protein should be classified within ACP-like_sf, ACP-like_sf, ACP-like_sf, Thiolase-like, Thiolase-like, Thiolase-like, NAD(P)-bd_dom_sf, NAD(P)-bd_dom_sf, Malonyl_transacylase_ACP-bd, Ac_transferase_dom_sf, Ac_transferase_dom_sf, Ac_transferase_dom_sf, NAD(P)-bd_dom_sf, GroES-like_sf, PKS_dehydratase_sf, PKS_dehydratase_sf, Thiolase-like, Acyl_Trfase/lysoPLipase, NAD(P)-bd_dom_sf, Acyl_Trfase/lysoPLipase, NAD(P)-bd_dom_sf, Acyl_Trfase/lysoPLipase, ACP-like_sf, NAD(P)-bd_dom_sf, Malonyl_transacylase_ACP-bd, ACP-like_sf, Thiolase-like, Thiolase-like, Malonyl_transacylase_ACP-bd, ACP-like_sf, Polyketide_synth_docking_sf, NAD(P)-bd_dom_sf sharing conserved structural features; 4. The protein should contain Quin_OxRdtase/zeta-crystal_CS that is preserved across related proteins; 5. The protein must have Ketoacyl_synth_AS, Ketoacyl_synth_AS, Ketoacyl_synth_AS that is conserved among related catalytic enzymes; 6. The protein should contain Ppantetheine_attach_site, Ppantetheine_attach_site, Ppantetheine_attach_site that allow regulation through chemical modifications. The designed protein sequence is ", "reference": "MSVPPPGATPSRTSRTKGLKDRPRMENEEKLVEYLKRATTDLRQARRRLREVEDQQQEPVAIIGMSCRYPGDVHSPDDLWRMVADGDDGISTFPAERGWDVERLYDPDPDRPGTTYTTRGGFLHDAHLFDAEFFGISPREALATDPQQRLLLETSWEAFERAGIDPTSLRGSHTGVFAGVMYQDYAHRVRPVPEEFEGYLGNGSAGSIASGRVAYTFGLEGPAVTVDTACSSSLVALHLAVQSLRQGDSTLALAGGVAIMSTPDVFVEYSRQRGLAADGRCKAFAEAADGTGWAEGVGMLLLERLSDARRNGHPVLAVVRGSAVNQDGASSRLTAPNGPSQQRVIRQALANARLTPADVDVVEAHGTGTKLGDPIEAQALLATYGQDRPAERPLWLGSLKSNIGHTQAAAGVGGVIKMVMAIRHGVAPRTLHVDRPTPEVDWSAGAVELLTEARPWPETDRPRRAGVSAFGVSGTNAHVIIEQPPAIEGTGLGDDAPPTAEHPEERTPADGGPAPQPVAWPLSAKSPEALRDQARQLRHHLTSGATASALSHPLADIGHSLATTRTAFDHRVVVLGTDHDALLRSLAALADGGTDPSVVQGSVRGRGRVAFVFPGQGSQWEGMARELLDTSPVFARQMQACADALSAYVDWSLHDVLRGAPDAPGLDRVDVVQPVLWAIMISLSELWRAHGVQPSAVVGHSQGEIAAAYVAGALSLDDSARVVALRSKALRALSGKGGMLSVPLSEEDLTPQLAAHTGQLSIAAVNGPGSVVVSGDADALEGLFEELTAAGVRARKVAVDYASHSAHVEALREELLTRLGPVAPRPAKVPFYSTVTGERLAGTEALDADYWYRNLRETVRFEQATRALLAQNIGVFVETGPHPVLAVGLQETIDATGGSAVALGSLRRGEGGPDRFLRSLAEAYAHGAPLDWDLLFPGARRVELPTYAFQRDHYWLQIPEGGPADAAGLGLAAVEHPLLAAATSLADGDGLIVTGRLSTRSLPWLADHAVTGTVLLPGTAFVELALRAADLTDCHLLDELTLHTPLVVPDDDPVRVQVRVAAPDPATGRRALTVHARPESPDGDADQEEQGAEWTLHATGYLAVGAHEPAVPDQGQWPPAGATPLDVTDLYPRLADAGYGYGLAFQGLRAAWRLGDDVYAEAELPDEHSDQAGRYGLHPALLDAALHAAGFAGFPDGDGALPGPRLPFSWTGVTLSAVGARALRIRLARTGDDTLTVTLTDPAGEPVATVESLALRPLATNQAPRTPSDLHRVAYTPRDLPADASTAHWAVLDADDLAYALNLPSHPDRDALAALDPAPPVVLTGWPVPDDPAPQAARTVLARALHDIQDWLADDRLADTRLVVVTHNALPADDWQDTDPVAASLTGLLRTAQSENPGRLVLIDTDGHPASWQALPALVATGEPQAALRLGEARVPRLAPAATDAALSVPAAVPAATDASLPVPADTSAWRLAVESPGTLDHLTLIPWAAATAPLEEGQVRIAVRTCGVNFRDVLIALGMYPDPDMLGSEGAGRVVEVGPGVTDLAVGDRVAGILAGGFGPLAVIDAPKVARIPDSWTWEQAASVPLAFATAWYALVDLAALAPGEKVLVHAAAGGVGMAAVQIARHLGAEVYATASPAKWDTLRALGLDDDHIASSRDTAFAEKFPAVDVVLDSLAGEFVDASLRLLPHGGRFVEMGKTDRRDPERIAADHPGVHYRAFDLRESGDRRLREMLDEIFALVEDGTLHPLPYRSWDLRRAPEAFRHMQQARHIGKIVLTVPPALDPDGTVLVTGATGTLGALVTRHLVTEHGVRRLLLVSRSGPQAPGADALLADLAAAGAEATLTACDTADRDQLRAVLDAVPADHPLTAVIHTAGALDDGVLSALTPERLDAVLRPKADAAWHLHELTAGHDLAAFVLFSSAAGLFGNAGQGNYAAANAFLDALAQHRRALGLPATSLAWGLWEERGGMTGHLDTADVGRLSRTGVATLDSAHGLALFDAALSTGQTLLVPLPLDRAALHRQARTGSLPALLSGLVRTTPARRTATGTAATGSVGDTLARRLTAAAPADRDRIVNDLVRDHAAAVLGHGSATAVGLGRAFRDLGFDSLTAVELRNRLGAATGLRLPATLVFDHPTPEELAAHLRDTLLGAADSGAAAVVTTSAEADEPLAVVAMSCRFPGGTGSPEELWELLADGGDAIGALPADRGWDLAGLYHPDPDQPGTSYARHGGFLHDAGDFDASLFGISPREALAMDPQQRLLLETSWEAFERAGLDLRTLRGSRTGVYVGALPSSYGGTLHDAPDGLEGHLMTGNSTSIVSGRLAYTFGLQGPAVTVDTACSSSLVALHLAVQALRSGEVTMALVGGATVMSNPGGLIAFSRQRGLAADGRCKAFSAAADGMGMAEGVGMLLVERLSDAERLGHPVLAVVRGSAINQDGASNGLTAPNGPSQQRVIRDALADARLNASEVDVVEAHGTGTKLGDPIEAQALLATYGQDRPEERPVLLGSVKSNIGHTQAAAGVAGVIKMVLAMRHGLLPRTLHVDEPSTQIDWNAGALSLLAEETPWPETGRPRRAAVSSFGISGTNAHVILEQAPASVPAPASASVPGDSGEAPDPVVVPWVVSGRSADALRAQAGQLAAWADSAAGRDTEPVDVGRALATARSFLEHRAVVVGGDRAELVEALRALATDPAAGSTAADPDGPGGRLGLVFSGQGSQRPGMGRELYTAYPVFAAALDEVCGVLDEVMGAQPPSEGWTGSLREVMFEVSSDLLDETGFTQPALFAFEVALYRLLESWGVAGEVVAGHSVGEIAAAHVAGVLSLADACALVAARGRLMQALPSGGAMVAVEASEEEVAAVLAGRGDEGAGIGAVNAPGSVVVSGVEAAVEEVAARFAGLGRRTRRLKVSHAFHSPLMDPMLAEFRRVVEGLSFAPPRMTVVSTLTGAVASDEELCSVDYWVRHARETVRFGDAVRCMAGAEVDRFAEVGPSGVLAGLVRASVTGEGTRAAVALQRGNRTEPGALVSALGELFVSGLPVDWATYFAGRPLRRVELPTYAFQRARYWLEGAAGAGGRQSAADGQDEVDAAFWEAVEHGDLSALGAGLDVDGEARLADVLPALSSWRRRAEQASVVDAWRYRVTWAPLPEPARASATGVWLLLVPAGAEDAADATRTVEGALAEHGGEVVKVDVAHPEADEARTALAQQITEQFIERFGVTEIGRLRGVVSLLALADGDDPRHPSVSRGLALTLGLVQALGDMELTAPLWCLTRGAVAVDASDGVDGAVQAQVWGLGRAVALEHPDRWGGLVDLPEYVDPRTARRLTGVLTGTGAGAGAGGLGREDQIALRATGAFGCRLTRDTVAPAGDPGEWTLSGTVLVTGGTGAVGGHVARWLAARGAERLVLVSRRGPRAPGADALRDELTAAGAQVEMLACDLSDGSAVTALVAGLAAGGDLTAVVHAAGVLDDGVLASLSVERCAEVLAAKARAAHHLDLATRDVNLDAFVLFSSVSGVLGAAGQANYAAANAHLDAVALHRHALGLPAVSVAWGPWAEGGMAGEDAAAGRLSRDGWTAMAPEPAATAMARAVAAGHPAVMIADVDWQRFAPAYAAVRPGNSLLTGVPEARQAQPQPWSADGERSAWASRLAGLPEEEQRTALLDLVRGQVASVLGHASMQTIDPARAFKEIGFDSLTAVELRNRLNAATGLALPATLVFDYPTPVALAEYVGSQVLGTSSPAVTGPLVVAAVDEPVAIIGMSCRFPGGVQSPEELWDLVVGGRDAISSFPTDRGWDVDALFDPDPEKPGKTYTRHGAFLHDAAEFDPRFFGISPREASAMDPQQRLLLETAWEAFERAGIDPAALRGSATGVFTGTNGQDYATRLRETPQGVEGYLMTGNAGSVISGRLAYTFGLEGPAMTVDTACSASLVALHLAAQALRQGECSLALAGGATVMSTPGAFVEFSRQGGLAADGRCKAFSASADGTGWGEGVGLLLLERLSDAERNGHPVLAVVRGSAVNQDGASNGLTAPNGPSQQRVIRQALANARLSASEVDVVEAHGTGTRLGDPIEAQALLATYGQDRPEDRPLWLGSVKSNLGHTQAAAGVAGIIKSVMAMRHGVLPATLHVDEPTSEVDWSAGAVELLTEARPWPEVGRPRRAAVSGFGVSGTNAHVILEQAAETGSTSEEGPAALVPTVVWPISGRDEQALRGQARRLRERLVVEPGLSAADVGLSLATTRSCFEQRAVVVGETRDELLAGLEALAEGREASGLVRGSARGSVNVGFLFSGQGSQRVGMGRELAERFPVFAGVFGEVCGLLDPLLPRPLGEVIAAGPGVLGRTVFTQPALFAVEVAAARLLLSWGVRPQVVAGHSVGEIAAAHVAGVLSLEDACALVAARGRLMEALPAGGVMVALEATEGEVAELLEAHAGAPVGVAAVNGPRAVVVSGDASPVGEIADVVRSWGRRTKRLEVSHAFHSPLMEPMLAEFTEVVSGLEFAAPQIGFVSAVTGGLVGADVVSRPEYWVEHVAQPVRFADAVRAAVDEAGVSLFVEVGPGGALSAMGPDCLDETVGDKQPVVFVPSLRADRPEPLAVTTALATAHVNGVQPDWQAVFAGTGAARVELPTYAFQRGRYWLDASVGGTGDASAVGLATLEHPLLAGVVDLAEEDRTVFTGRLSLTTHPWLADHAVFGSVLLPGTGFVELALAAGQYTGFGHLDELTVHAPLVLPARGAVHVQLVLDGVDDSGRRALTVHSRPEGVAGEQTWTRHATGALTVAEAVDPPAVSAVWPPAGAIEVELDDPYERFAAEGYAYGPAFQGLRRVWRGDGELFAEVELGAQELEAAGRFGVHPALLDAALHPLLLADGSTGQDGDTPTAGRLPFSWTGVSLRATGATTARVTLAFTDGDAVRITVADGDGGLVASVDALVTRPIAAGQLAAGRSGLFEVEWAPVSSSPAGSASWAVVGGGEAGVSAGGPGLGSYEDLAALRRAMDSGAPVPEVVFAHCGGGAEAADVVGGTHTATHAALVSLREWLADERFAGARLAIVTGGAVAVRPGDEVSDLAGAAVWGLVRSAQSEHPGQFVLVDTDGAAEPSSAAAALATGEPQVAVRGGEVFVPRLARADRTPAADSGVRWDPDKSLLVTGASGVLAGLVVRHAVAEWAVRHVVLVSRSGADGLAQELAEAGVSVQQARCDVADREAVAAVLAGIPAEHRLGGVIHTAGVLDDGVIESLTPERLAPVLRPKVDGAWWLHELTADVDLSVFAVFSSAAGVFGAAGQGNYAAANAFLDALALYRHREGLPATSLSWGLWAERSGMAGQLADAQLERLERTGVHPLSSSEGLALLDAALATGRPWLVPVGLDLGVMRAQADLGVTPLFRGLVRAPLRRAQVDKAASNAPDELRRELAVASAADRERMVLDLVRDRTAVVLGFGSRDEVGVDSGFTSMGVDSLAGVDLRNRLSSATGLRLPTTLIFDYPTPAALARYLHTHLVDDAVDQVDIRSVLAELDRLEATLAQVQAGDVGHMKIASRLQDLVGQWHGSGGATPGEDTVTDLEEATADEIFSFIDDNFGSTEVH" }, { "InterPro": [ { "InterPro-ID": "IPR009081", "InterPro-Name": "PP-bd_ACP", "InterPro-Type": "DOMAIN", "Beg": 2072, "End": 2147 }, { "InterPro-ID": "IPR002364", "InterPro-Name": "Quin_OxRdtase/zeta-crystal_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 1279, "End": 1300 }, { "InterPro-ID": "IPR015083", "InterPro-Name": "NorB/c/GfsB-D-like_docking", "InterPro-Type": "DOMAIN", "Beg": 2, "End": 30 }, { "InterPro-ID": "IPR013154", "InterPro-Name": "ADH-like_N", "InterPro-Type": "DOMAIN", "Beg": 1171, "End": 1249 }, { "InterPro-ID": "IPR011032", "InterPro-Name": "GroES-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1160, "End": 1284 }, { "InterPro-ID": "IPR013968", "InterPro-Name": "PKS_KR", "InterPro-Type": "DOMAIN", "Beg": 1786, "End": 1964 }, { "InterPro-ID": "IPR016039", "InterPro-Name": "Thiolase-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 31, "End": 407 }, { "InterPro-ID": "IPR042104", "InterPro-Name": "PKS_dehydratase_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 918, "End": 1134 }, { "InterPro-ID": "IPR020806", "InterPro-Name": "PKS_PP-bd", "InterPro-Type": "DOMAIN", "Beg": 2075, "End": 2147 }, { "InterPro-ID": "IPR049900", "InterPro-Name": "PKS_mFAS_DH", "InterPro-Type": "DOMAIN", "Beg": 935, "End": 1239 }, { "InterPro-ID": "IPR036291", "InterPro-Name": "NAD(P)-bd_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1250, "End": 1387 }, { "InterPro-ID": "IPR049551", "InterPro-Name": "PKS_DH_C", "InterPro-Type": "DOMAIN", "Beg": 1067, "End": 1129 }, { "InterPro-ID": "IPR049551", "InterPro-Name": "PKS_DH_C", "InterPro-Type": "DOMAIN", "Beg": 1486, "End": 1584 }, { "InterPro-ID": "IPR018201", "InterPro-Name": "Ketoacyl_synth_AS", "InterPro-Type": "ACTIVE_SITE", "Beg": 196, "End": 212 }, { "InterPro-ID": "IPR055123", "InterPro-Name": "SpnB-like_Rossmann", "InterPro-Type": "DOMAIN", "Beg": 1602, "End": 1770 }, { "InterPro-ID": "IPR014043", "InterPro-Name": "Acyl_transferase_dom", "InterPro-Type": "DOMAIN", "Beg": 564, "End": 885 }, { "InterPro-ID": "IPR042104", "InterPro-Name": "PKS_dehydratase_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1466, "End": 1587 }, { "InterPro-ID": "IPR036299", "InterPro-Name": "Polyketide_synth_docking_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 3, "End": 32 }, { "InterPro-ID": "IPR050091", "InterPro-Name": "PKS_NRPS_Biosynth_Enz", "InterPro-Type": "FAMILY", "Beg": 1781, "End": 2146 }, { "InterPro-ID": "IPR009081", "InterPro-Name": "PP-bd_ACP", "InterPro-Type": "DOMAIN", "Beg": 2077, "End": 2143 }, { "InterPro-ID": "IPR020807", "InterPro-Name": "PKS_DH", "InterPro-Type": "DOMAIN", "Beg": 935, "End": 1103 }, { "InterPro-ID": "IPR014030", "InterPro-Name": "Ketoacyl_synth_N", "InterPro-Type": "DOMAIN", "Beg": 34, "End": 283 }, { "InterPro-ID": "IPR036291", "InterPro-Name": "NAD(P)-bd_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1595, "End": 1773 }, { "InterPro-ID": "IPR032821", "InterPro-Name": "PKS_assoc", "InterPro-Type": "DOMAIN", "Beg": 411, "End": 528 }, { "InterPro-ID": "IPR020841", "InterPro-Name": "PKS_Beta-ketoAc_synthase_dom", "InterPro-Type": "DOMAIN", "Beg": 36, "End": 461 }, { "InterPro-ID": "IPR036736", "InterPro-Name": "ACP-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 2053, "End": 2149 }, { "InterPro-ID": "IPR016035", "InterPro-Name": "Acyl_Trfase/lysoPLipase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 563, "End": 856 }, { "InterPro-ID": "IPR006162", "InterPro-Name": "Ppantetheine_attach_site", "InterPro-Type": "PTM", "Beg": 2102, "End": 2117 }, { "InterPro-ID": "IPR049552", "InterPro-Name": "PKS_DH_N", "InterPro-Type": "DOMAIN", "Beg": 935, "End": 1035 }, { "InterPro-ID": "IPR020841", "InterPro-Name": "PKS_Beta-ketoAc_synthase_dom", "InterPro-Type": "DOMAIN", "Beg": 33, "End": 458 }, { "InterPro-ID": "IPR016036", "InterPro-Name": "Malonyl_transacylase_ACP-bd", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 692, "End": 757 }, { "InterPro-ID": "IPR036736", "InterPro-Name": "ACP-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 2067, "End": 2151 }, { "InterPro-ID": "IPR036291", "InterPro-Name": "NAD(P)-bd_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1785, "End": 1991 }, { "InterPro-ID": "IPR014031", "InterPro-Name": "Ketoacyl_synth_C", "InterPro-Type": "DOMAIN", "Beg": 291, "End": 408 }, { "InterPro-ID": "IPR016039", "InterPro-Name": "Thiolase-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 25, "End": 470 }, { "InterPro-ID": "IPR001227", "InterPro-Name": "Ac_transferase_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 563, "End": 870 }, { "InterPro-ID": "IPR020843", "InterPro-Name": "PKS_ER", "InterPro-Type": "DOMAIN", "Beg": 1152, "End": 1457 }, { "InterPro-ID": "IPR014043", "InterPro-Name": "Acyl_transferase_dom", "InterPro-Type": "DOMAIN", "Beg": 565, "End": 867 } ], "response#1": "MTDEAKLLSYLKRVTADLDRTTRRLREAEEQRYEAIAIVGMACRYPGGVRSPEELWRLVADEADAVSHFPQNRGWDLDTLFDPERAGGTSLTQEGGFLYDADQFDAGFFGIGPREATAMDPQQRLLLETSWEALERAGIDPATLRGSATGVFAGVMYHDYGARVVEVPEEVEGYLGNGNAGSIASGRVAFTFGFEGPAVTLDTACSSSLVALHLAAQALRQGECSLALAGGVTVMATPGVFTEFTRQGGLAADGRCKSFSTTADGTGWSEGAGMLLLERLSDAERNGHLVLAVVRGSAVNQDGASSGLTAPNGPAQQRVIRQALANARLSASEVDVVEAHGTGTKLGDPIEAQALLATYGQDRAEDRPLWLGSVKSNLGHTQAAAGVAGIIKSVMAMRHGVLPATLHVDEPTSEVDWSAGAVELLTKSRSWPETGRPRRAAVSGFGVSGTNAHVILEQAADLDVPDAAPVPEGVPVPWVVSARSADALRAQARRLRGHMAAEPGAAVVDVGHSLATARSCFEHRAVVIGRTTDDLLAGLEALAEGRGDSRVRVGAGLAGGRTGFVFAGQGSQRLGMGGRLREMFPVFGEAWDEVVAELDGRLGRPLGEVVFAEEGSEQASLVDRTEFTQPALFAFEVALFRLLESWGVVPDVVAGHSIGELAAAYVAGVLSLSDACALVVARGRLMQALPAGGAMVAVQVTEAEARRLVEGEPSGAVDIAAVNGPESVVIAGDEDVVLRVQEIVRGRGRKTKRLTVSHAFHSPRMEPMLDEFRRVAETVTYHEPRIAVVSAVSGEVAGAELRSAEYWTRHVREAVRFYDAVRCLRSEGVSTFVEVGPDGALSALGQDCLVGEEARGTEFVSTVRAGRDEAESVVAAVGAAHVRGVPVDWAAYYAPYGPRRAGLPTYAFEHQRYWLDASVRTVGDLAGLGLGSAEHPLLGAAVALADGDGVLLTGRLSLATHPWLADHRVQGAVLFPGTAFVELALRAGEQVGADCVEELTLEVPLVLPERGGVQVQVVVGAADEQGGRPVTVYSRPDEDVEDEPWARHAIGMLVPFAASAAVPAEDADFAVWPPQDAVAVDTDGMYDRLAEGGLEYGPVFQGLRSVWRRGSEVFAEVALDDTHRDGAEHDVSAVSAPETTAPVWRLEATGGGTLDALALVAYEETDRPLRANEVRVEVHAAGLNFRDVLITLGMLETKDKLGWELSGVVLETGPDVTGLAPGDRVMGVALGSFAQQAVADHRMLAKIPDGWSYAEAASVPLVFLTAYYSLVDLADLRAGQSVLIHAAAGGVGMAAVQLARHLGAEVFGTASTGKWDALRAQGLDETHIASSRDLEFEPRVLEATDGRGVDVVLDALAGEFVDASLRTLTHGGRFIEMGKTDIRDAEEVAARYPGVHYRAFDLIEAGPERVGQMLAEVLRLFDDGALTVLPVTTWDLLSAPDAFRHLSQARHIGKVVLTVPRTIDPYDTELAVVTRSRSRWRTGRSSARLTANPNSAGEFGLHPALLDAALHAIGFGEFVSDGGAGVLPFSWSGVRLLASGADALRVRVSGVGVGANEVALVVADGSGRPVASVDSLALRPVSADGIGAGRSGASRQSLFRVGWRQVAVPDQAGAGEWVALDRGAGWAQGEGCEVLPDLAALGSAVSAGRSVPRLVVAHFAADREVPVTAGVRGVTAEGLELIQSWLADERFADSRLVIMTRQAVAVDAGEGVFDLGAAALWGLVRTAQSEQPGRVVLVDVDDLDAVSRVVGIGDEPQLAVRDGRVFVPRLMRAEAIDGVPVWDPEGTLLITGASGALGGVVARHVVREWGVRHLVLASRRGAEAPGMTELVAELGELGASAAPVACDVADRDALAAVLAGIPAVHRLAGVVHAAGVLDDGVVGSLTPERLETVLAPKADAAWHLHELAAELDLSVFVLFSSAASVFGGAGQGNYAAANAFLDALAARRRADGLVATSLSWGLWDQAGGMTGQLGEADVARMSRSGVLPISVGEALPLLDAGVTGGDAWLAPVRLDLAALRQQAIATGGVPALLRDLVRVPNRRKAETGGSGAGSRSSLTDKLAGLPQEERAQELLDFVCEHTAAVLGHSGAGMVDPGRNFRELGIDSLAAVELRNRIGGVLGIRLSATLVFDYPSPVLLAGHIGEQLALDEPAPRLPVVAELERLEAAVSAARFDEDSRDDVAARLRKLLSHLDALAASPKREADDGELASASVEELFALVDQELEDL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more PP-bd_ACP, NorB/c/GfsB-D-like_docking, ADH-like_N, PKS_KR, PKS_PP-bd, PKS_mFAS_DH, PKS_DH_C, PKS_DH_C, SpnB-like_Rossmann, Acyl_transferase_dom, PP-bd_ACP, PKS_DH, Ketoacyl_synth_N, PKS_assoc, PKS_Beta-ketoAc_synthase_dom, PKS_DH_N, PKS_Beta-ketoAc_synthase_dom, Ketoacyl_synth_C, PKS_ER, Acyl_transferase_dom that are essential for its biological function; 2. The protein should belong to PKS_NRPS_Biosynth_Enz that shares evolutionary origin and functional similarity; 3. The protein should be classified within GroES-like_sf, Thiolase-like, PKS_dehydratase_sf, NAD(P)-bd_dom_sf, PKS_dehydratase_sf, Polyketide_synth_docking_sf, NAD(P)-bd_dom_sf, ACP-like_sf, Acyl_Trfase/lysoPLipase, Malonyl_transacylase_ACP-bd, ACP-like_sf, NAD(P)-bd_dom_sf, Thiolase-like, Ac_transferase_dom_sf sharing conserved structural features; 4. The protein should contain Quin_OxRdtase/zeta-crystal_CS that is preserved across related proteins; 5. The protein must have Ketoacyl_synth_AS that is conserved among related catalytic enzymes; 6. The protein should contain Ppantetheine_attach_site that allow regulation through chemical modifications. The designed protein sequence is ", "reference": "MTDEAKLLSYLKRVTADLDRTTRRLREAEEQRYEAIAIVGMACRYPGGVRSPEELWRLVADEADAVSHFPQNRGWDLDTLFDPERAGGTSLTQEGGFLYDADQFDAGFFGIGPREATAMDPQQRLLLETSWEALERAGIDPATLRGSATGVFAGVMYHDYGARVVEVPEEVEGYLGNGNAGSIASGRVAFTFGFEGPAVTLDTACSSSLVALHLAAQALRQGECSLALAGGVTVMATPGVFTEFTRQGGLAADGRCKSFSTTADGTGWSEGAGMLLLERLSDAERNGHLVLAVVRGSAVNQDGASSGLTAPNGPAQQRVIRQALANARLSASEVDVVEAHGTGTKLGDPIEAQALLATYGQDRAEDRPLWLGSVKSNLGHTQAAAGVAGIIKSVMAMRHGVLPATLHVDEPTSEVDWSAGAVELLTKSRSWPETGRPRRAAVSGFGVSGTNAHVILEQAADLDVPDAAPVPEGVPVPWVVSARSADALRAQARRLRGHMAAEPGAAVVDVGHSLATARSCFEHRAVVIGRTTDDLLAGLEALAEGRGDSRVRVGAGLAGGRTGFVFAGQGSQRLGMGGRLREMFPVFGEAWDEVVAELDGRLGRPLGEVVFAEEGSEQASLVDRTEFTQPALFAFEVALFRLLESWGVVPDVVAGHSIGELAAAYVAGVLSLSDACALVVARGRLMQALPAGGAMVAVQVTEAEARRLVEGEPSGAVDIAAVNGPESVVIAGDEDVVLRVQEIVRGRGRKTKRLTVSHAFHSPRMEPMLDEFRRVAETVTYHEPRIAVVSAVSGEVAGAELRSAEYWTRHVREAVRFYDAVRCLRSEGVSTFVEVGPDGALSALGQDCLVGEEARGTEFVSTVRAGRDEAESVVAAVGAAHVRGVPVDWAAYYAPYGPRRAGLPTYAFEHQRYWLDASVRTVGDLAGLGLGSAEHPLLGAAVALADGDGVLLTGRLSLATHPWLADHRVQGAVLFPGTAFVELALRAGEQVGADCVEELTLEVPLVLPERGGVQVQVVVGAADEQGGRPVTVYSRPDEDVEDEPWARHAIGMLVPFAASAAVPAEDADFAVWPPQDAVAVDTDGMYDRLAEGGLEYGPVFQGLRSVWRRGSEVFAEVALDDTHRDGAEHDVSAVSAPETTAPVWRLEATGGGTLDALALVAYEETDRPLRANEVRVEVHAAGLNFRDVLITLGMLETKDKLGWELSGVVLETGPDVTGLAPGDRVMGVALGSFAQQAVADHRMLAKIPDGWSYAEAASVPLVFLTAYYSLVDLADLRAGQSVLIHAAAGGVGMAAVQLARHLGAEVFGTASTGKWDALRAQGLDETHIASSRDLEFEPRVLEATDGRGVDVVLDALAGEFVDASLRTLTHGGRFIEMGKTDIRDAEEVAARYPGVHYRAFDLIEAGPERVGQMLAEVLRLFDDGALTVLPVTTWDLLSAPDAFRHLSQARHIGKVVLTVPRTIDPYDTELAVVTRSRSRWRTGRSSARLTANPNSAGEFGLHPALLDAALHAIGFGEFVSDGGAGVLPFSWSGVRLLASGADALRVRVSGVGVGANEVALVVADGSGRPVASVDSLALRPVSADGIGAGRSGASRQSLFRVGWRQVAVPDQAGAGEWVALDRGAGWAQGEGCEVLPDLAALGSAVSAGRSVPRLVVAHFAADREVPVTAGVRGVTAEGLELIQSWLADERFADSRLVIMTRQAVAVDAGEGVFDLGAAALWGLVRTAQSEQPGRVVLVDVDDLDAVSRVVGIGDEPQLAVRDGRVFVPRLMRAEAIDGVPVWDPEGTLLITGASGALGGVVARHVVREWGVRHLVLASRRGAEAPGMTELVAELGELGASAAPVACDVADRDALAAVLAGIPAVHRLAGVVHAAGVLDDGVVGSLTPERLETVLAPKADAAWHLHELAAELDLSVFVLFSSAASVFGGAGQGNYAAANAFLDALAARRRADGLVATSLSWGLWDQAGGMTGQLGEADVARMSRSGVLPISVGEALPLLDAGVTGGDAWLAPVRLDLAALRQQAIATGGVPALLRDLVRVPNRRKAETGGSGAGSRSSLTDKLAGLPQEERAQELLDFVCEHTAAVLGHSGAGMVDPGRNFRELGIDSLAAVELRNRIGGVLGIRLSATLVFDYPSPVLLAGHIGEQLALDEPAPRLPVVAELERLEAAVSAARFDEDSRDDVAARLRKLLSHLDALAASPKREADDGELASASVEELFALVDQELEDL" }, { "InterPro": [ { "InterPro-ID": "IPR036736", "InterPro-Name": "ACP-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 3449, "End": 3544 }, { "InterPro-ID": "IPR036736", "InterPro-Name": "ACP-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1639, "End": 1737 }, { "InterPro-ID": "IPR016036", "InterPro-Name": "Malonyl_transacylase_ACP-bd", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 695, "End": 760 }, { "InterPro-ID": "IPR013968", "InterPro-Name": "PKS_KR", "InterPro-Type": "DOMAIN", "Beg": 1385, "End": 1557 }, { "InterPro-ID": "IPR013968", "InterPro-Name": "PKS_KR", "InterPro-Type": "DOMAIN", "Beg": 3185, "End": 3363 }, { "InterPro-ID": "IPR014043", "InterPro-Name": "Acyl_transferase_dom", "InterPro-Type": "DOMAIN", "Beg": 2289, "End": 2425 }, { "InterPro-ID": "IPR014043", "InterPro-Name": "Acyl_transferase_dom", "InterPro-Type": "DOMAIN", "Beg": 2441, "End": 2642 }, { "InterPro-ID": "IPR014043", "InterPro-Name": "Acyl_transferase_dom", "InterPro-Type": "DOMAIN", "Beg": 572, "End": 894 }, { "InterPro-ID": "IPR018201", "InterPro-Name": "Ketoacyl_synth_AS", "InterPro-Type": "ACTIVE_SITE", "Beg": 197, "End": 213 }, { "InterPro-ID": "IPR015083", "InterPro-Name": "NorB/c/GfsB-D-like_docking", "InterPro-Type": "DOMAIN", "Beg": 3, "End": 30 }, { "InterPro-ID": "IPR014030", "InterPro-Name": "Ketoacyl_synth_N", "InterPro-Type": "DOMAIN", "Beg": 1753, "End": 2002 }, { "InterPro-ID": "IPR014030", "InterPro-Name": "Ketoacyl_synth_N", "InterPro-Type": "DOMAIN", "Beg": 34, "End": 284 }, { "InterPro-ID": "IPR016036", "InterPro-Name": "Malonyl_transacylase_ACP-bd", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 2437, "End": 2499 }, { "InterPro-ID": "IPR014031", "InterPro-Name": "Ketoacyl_synth_C", "InterPro-Type": "DOMAIN", "Beg": 2010, "End": 2127 }, { "InterPro-ID": "IPR014031", "InterPro-Name": "Ketoacyl_synth_C", "InterPro-Type": "DOMAIN", "Beg": 292, "End": 409 }, { "InterPro-ID": "IPR036291", "InterPro-Name": "NAD(P)-bd_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1232, "End": 1366 }, { "InterPro-ID": "IPR018201", "InterPro-Name": "Ketoacyl_synth_AS", "InterPro-Type": "ACTIVE_SITE", "Beg": 1915, "End": 1931 }, { "InterPro-ID": "IPR020841", "InterPro-Name": "PKS_Beta-ketoAc_synthase_dom", "InterPro-Type": "DOMAIN", "Beg": 33, "End": 462 }, { "InterPro-ID": "IPR009081", "InterPro-Name": "PP-bd_ACP", "InterPro-Type": "DOMAIN", "Beg": 1655, "End": 1733 }, { "InterPro-ID": "IPR036736", "InterPro-Name": "ACP-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 3463, "End": 3552 }, { "InterPro-ID": "IPR014043", "InterPro-Name": "Acyl_transferase_dom", "InterPro-Type": "DOMAIN", "Beg": 2291, "End": 2625 }, { "InterPro-ID": "IPR014043", "InterPro-Name": "Acyl_transferase_dom", "InterPro-Type": "DOMAIN", "Beg": 573, "End": 874 }, { "InterPro-ID": "IPR016039", "InterPro-Name": "Thiolase-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1752, "End": 2124 }, { "InterPro-ID": "IPR049900", "InterPro-Name": "PKS_mFAS_DH", "InterPro-Type": "DOMAIN", "Beg": 943, "End": 1225 }, { "InterPro-ID": "IPR020807", "InterPro-Name": "PKS_DH", "InterPro-Type": "DOMAIN", "Beg": 943, "End": 1106 }, { "InterPro-ID": "IPR020807", "InterPro-Name": "PKS_DH", "InterPro-Type": "DOMAIN", "Beg": 2691, "End": 2849 }, { "InterPro-ID": "IPR050091", "InterPro-Name": "PKS_NRPS_Biosynth_Enz", "InterPro-Type": "FAMILY", "Beg": 1377, "End": 1731 }, { "InterPro-ID": "IPR036736", "InterPro-Name": "ACP-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1657, "End": 1768 }, { "InterPro-ID": "IPR016039", "InterPro-Name": "Thiolase-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 25, "End": 483 }, { "InterPro-ID": "IPR016039", "InterPro-Name": "Thiolase-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1746, "End": 2195 }, { "InterPro-ID": "IPR016039", "InterPro-Name": "Thiolase-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 31, "End": 406 }, { "InterPro-ID": "IPR020841", "InterPro-Name": "PKS_Beta-ketoAc_synthase_dom", "InterPro-Type": "DOMAIN", "Beg": 36, "End": 465 }, { "InterPro-ID": "IPR020841", "InterPro-Name": "PKS_Beta-ketoAc_synthase_dom", "InterPro-Type": "DOMAIN", "Beg": 1755, "End": 2180 }, { "InterPro-ID": "IPR032821", "InterPro-Name": "PKS_assoc", "InterPro-Type": "DOMAIN", "Beg": 412, "End": 535 }, { "InterPro-ID": "IPR032821", "InterPro-Name": "PKS_assoc", "InterPro-Type": "DOMAIN", "Beg": 2130, "End": 2243 }, { "InterPro-ID": "IPR036291", "InterPro-Name": "NAD(P)-bd_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 3181, "End": 3447 }, { "InterPro-ID": "IPR001227", "InterPro-Name": "Ac_transferase_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 2289, "End": 2628 }, { "InterPro-ID": "IPR001227", "InterPro-Name": "Ac_transferase_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 571, "End": 877 }, { "InterPro-ID": "IPR036291", "InterPro-Name": "NAD(P)-bd_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 2965, "End": 3158 }, { "InterPro-ID": "IPR016035", "InterPro-Name": "Acyl_Trfase/lysoPLipase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 570, "End": 856 }, { "InterPro-ID": "IPR036291", "InterPro-Name": "NAD(P)-bd_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1380, "End": 1619 }, { "InterPro-ID": "IPR016035", "InterPro-Name": "Acyl_Trfase/lysoPLipase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 2287, "End": 2593 }, { "InterPro-ID": "IPR009081", "InterPro-Name": "PP-bd_ACP", "InterPro-Type": "DOMAIN", "Beg": 3472, "End": 3538 }, { "InterPro-ID": "IPR009081", "InterPro-Name": "PP-bd_ACP", "InterPro-Type": "DOMAIN", "Beg": 1664, "End": 1729 }, { "InterPro-ID": "IPR006162", "InterPro-Name": "Ppantetheine_attach_site", "InterPro-Type": "PTM", "Beg": 3497, "End": 3512 }, { "InterPro-ID": "IPR055123", "InterPro-Name": "SpnB-like_Rossmann", "InterPro-Type": "DOMAIN", "Beg": 3039, "End": 3154 }, { "InterPro-ID": "IPR055123", "InterPro-Name": "SpnB-like_Rossmann", "InterPro-Type": "DOMAIN", "Beg": 1274, "End": 1341 }, { "InterPro-ID": "IPR049552", "InterPro-Name": "PKS_DH_N", "InterPro-Type": "DOMAIN", "Beg": 943, "End": 1042 }, { "InterPro-ID": "IPR049552", "InterPro-Name": "PKS_DH_N", "InterPro-Type": "DOMAIN", "Beg": 2691, "End": 2791 }, { "InterPro-ID": "IPR006162", "InterPro-Name": "Ppantetheine_attach_site", "InterPro-Type": "PTM", "Beg": 1688, "End": 1703 }, { "InterPro-ID": "IPR042104", "InterPro-Name": "PKS_dehydratase_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 2680, "End": 2960 }, { "InterPro-ID": "IPR042104", "InterPro-Name": "PKS_dehydratase_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 932, "End": 1227 }, { "InterPro-ID": "IPR020806", "InterPro-Name": "PKS_PP-bd", "InterPro-Type": "DOMAIN", "Beg": 1661, "End": 1733 }, { "InterPro-ID": "IPR020806", "InterPro-Name": "PKS_PP-bd", "InterPro-Type": "DOMAIN", "Beg": 3470, "End": 3542 }, { "InterPro-ID": "IPR036299", "InterPro-Name": "Polyketide_synth_docking_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 4, "End": 34 }, { "InterPro-ID": "IPR049551", "InterPro-Name": "PKS_DH_C", "InterPro-Type": "DOMAIN", "Beg": 1068, "End": 1224 }, { "InterPro-ID": "IPR049551", "InterPro-Name": "PKS_DH_C", "InterPro-Type": "DOMAIN", "Beg": 2814, "End": 2955 }, { "InterPro-ID": "IPR020841", "InterPro-Name": "PKS_Beta-ketoAc_synthase_dom", "InterPro-Type": "DOMAIN", "Beg": 1752, "End": 2177 }, { "InterPro-ID": "IPR009081", "InterPro-Name": "PP-bd_ACP", "InterPro-Type": "DOMAIN", "Beg": 3467, "End": 3542 }, { "InterPro-ID": "IPR049900", "InterPro-Name": "PKS_mFAS_DH", "InterPro-Type": "DOMAIN", "Beg": 2691, "End": 2960 } ], "response#1": "MDNEEKLVEYLKRVTADLRQVRRRLREVEDQQREPIAIIGMSCRFPGGIHTPEDLWDLVAGGQDAITSFPTDRGWDLDALLDPDPDRPGTSHTRHGAFLHDAPEFDAAFFDIGPSEATAMDPQQRLLLETSWEAFERAGIDPAALRGSRTGVFVGTNVHDYLTGVRETPQEVEGYLMTGNTPSVASGRLAYTFGLEGPAVTVDTACSASLVALHLAAHSLRRDECSLALAGGATVMSAPGAFVEFSRQGGLAADGRCKAFSASADGTGWGEGVGLLLLERLSDAERNGHPILAVVRGSAVNQDGASNGLTAPNGPSQQRVIRQALADARLSPADVDLVEAHGTGTQLGDPIEAQALLATYGQDRPEDRPLWLGSVKSNIGHTQAAAGAAGVIKTVMAMRHGVAPQTLHVDEPTPEVDWSAGAVELLTEARPWPAASAAGRPRRAAVSGFGVSGTNAHVILEQGPEQADTDPLPAQRQPLEDTVFPWALSARNTDALLGQARRLRERLVVEPGLSAADVAFSLGTVRSSFEQRAVVVGETRDELLAGLEALAEGREASGLVRGSARGSVNLGFLFSGQGSQRVGMGRELAERFPVFAGVFGEVCGLLDPLLPRPLGEVIAAGPGVLGRTVFTQPALFAVEVAAARLLLSWGVRPQVVAGHSVGEIAAAHVAGVLSLEDACALVAARGRLMEALPAGGVMVALEATEEEVAELLEAHAGAPVGVAAVNGPRAVVVSGDASPVGEIADVVRSWGRRTKRLEVSHAFHSPLMEPMLAEFTDVVTGLSFSAPRIGFVSAVTGGLVGADVVSRPEYWVEHVAQPVRFADAVRAAVDEAGVSLFVEVGPGGALSAMGPDCLDETVGDKQPVVFVPSLRADRPEPLAVTTALATAHVNGVQPDWQAVFAGTGAARVELPTYAFQRRRFWLDGGRYGNGGGVASAGLASAGHPLLGAVVEVAGDDRTLLSGRLSLASHPWLADHAVRGVVLVPGAAFVELALCAGERVGCGAVEELTLQAPLVLPVEGAVQVQFAVEAPDERGHRAFTVYGRSDEAAEPVSWQEYASGVLELEARPEPEGLAQWPPADAEAVPVESLYDLLRGLGYEYGPAFQGLRRVWRRGEELFAEVSLAEELDGQADQFGIHPALLDGALHTSAVALLEHDDADHREVTGVRLPFAWRGVSLFATGASAARVRLSPAGQDAVSVLVADQDGVPVARVEGLVSRPVAEEQLGAGGGVGRDSLFGVEWVPFAGGDSDALAADVLEVHRFDGLVQDPQGVREAIERALGLIQGWLARERPRGSRLVVVTRGAVGGEVSDLAGAAVWGLVRSAQSEHPGQFVLVDTDGDALAGLPADEPHVMVREGQVLVPRLARVVPATEGGAGGVVWDPEKSLLVTGASGVLAGLVVRHAVAEWAVRHVVLVSRSGADGLAQELAEAGVSVQQARCDVADREAVAAVLAGIPAEHRLGGVIHTAGVLDDGVIESLTPERLAPVLRPKVDGAWWLHELTADVDLSVFAVFSSAAGVFGAAGQGNYAAANAFLDALALYRHREGLPATSLSWGLWAERSGMAGQLADAQLERLERTGARPLSSSEGLALLDAALATGRPWLVPARLDLGVLRTSDQPVPPLLRGLVRRITRRAVTAGANGADSFVQRIAGLSPTEAERAVLELVCGETAAVLGHANAGAVPPGQAFQELGFDSLSAVELRNRLNSATGLRLPATLIFDYPTPAVLAAHIHSATAGTTAGPIAPLTVPGTAVDEAIAIVGMACRYPGGVASPEDLWRLVADGTDAISRFPQDRGWDLEGLFDPQRARGTSLTREGGFLYDADQFDAAFFGISPREALAMDPQQRLLLETSWEALERAGIDPATLRGSATGVFAGVMYHDYATRILEAPEEVEGYLANGNAGSIASGRVAYTFGLEGPAVTVDTACSSSLVTLHLAAQALRQGECSLALAGGVTVMATPGTFIEFSRQQGLSSDGRCKSFSATADGTGWSEGVGMLILERLSDAERNGHPILAVVRGSAVNQDGASNGLTAPNGPSQQRVIRQALANARLTPADIDLVEAHGTGTRLGDPIEAQALLATYGQDRTDDQPLWLGSIKSNIGHTQAAAGVAGIIKAVMAMRHGTLPASLHVDEPTPEVDWDAGAVELLTRARPWPTTDRPRRAAVSSFGISGTNAHVILEHATDTVPATDLTGTASPLSPAATVVPWVLSARGQDALRAQAQRLRDSLHDRPDPALADIGLSLATTRGALDDRAVVLGGDRQQMLDGLAALAAGEPSARLVLGQARPRPPRVVFVFPGQGSQWGGMAVELMDTCPVFAESIARCGQALAQVVDWDLEEVLRDGTFERVDVIQPVLWAVMVSLAELWRACGVRPDAVVGHSQGEIAAACVAGSLSVEDAARVVALRSRALLDLAGQGAMASVFASAEQTELLVAEAAGAAGAVGATGATGVTGEADAADREGRLSVAAVNGPESTVVSGETAAVEAFLDLCERRQIRARRIPVDYASHSAQVEAVADQVREALSGVTGRTGDVPLFSTVTGEWVDGEALDADYWLRNLRRPVRFHEAVRHLARQGHDLFIEVSPHPVLTMGLEDSVTAPGQATTPAADPTDTPTTATAPPGVVATLRRDEGDWSRFLASLAEVHAYGQPVNWAAVLGPARIVDLPTYAFQHRGYWLSDIGGRTPDVAAAGLDPARHPLLGAAVETAGGEQVLLTGRLSTGTHPWLADHVIGGTALLPVSAFVEMALRAGRHVGLPRLDELTLHTPLVVSAADVVRLQVQLDPDDGTGRRPVQIFARTADAPWVRHASGTLTGDAPADFGLLVWPPADATPLPVEGHYDHLAALGYAYGPSFQALRAAWRDGDDLYAEVALDTSENTADYGLHPILLDAAAQTLTLDHRADADTGARMPFAWTGVTLHAPGGGTARVKVSPAGDSAVTIRIADAAGQPVASVESLVLRPVSLQQIAAASSVTQNSLFLVDWTDIPAGPATTTGDTDRRPVLRSRDELEALRRAVADGQPAPALAAFICAAPGATEAPGTDALGNDLAQAVRATTADTLDALRAWLDDDRLEESRLAIVTCRAVVTGTDGAGAGGLNLAQTPVWGLVRSAQAENPGRFLLVDVDDLDAVPDVLARLEGPEGPEGLNEPQVAVRGGQFTVPRLVRPATPTPTADTDTAARDLDPDLDRWNPDGTVLLVGASGGLGQVLARHLVVERGVRRLVLTSRRGEAADGMAELRAELTEAGAVVDIAACDATDRDALAAVLDAIPERHPLTAVVHAAAVLDDGVVTALTPERLDRVLRPKVDTALLLDELTRGLDLGAFVLFSSLSSTLGSPGVANYAAANAFLDGLAQRRRDAGLPATSLAWGLWAQSGGMGDRLSDADLSRMSSGGVTALTTQEGLALFDRALTLDLPVVVPAKIDLAELRRLSGDLLPALLRGLVPGTVRTAAQTADVRTAPALAERLAALGEEERARALLDLVRSQAAAVLGHADVTAVQADTPFRDIGADSLAAVQIRNRLAAATGLRLKATLVFDHPTPAAVARLLLDELAPEPTDAQPAVFADLDALEATLAGLTEAGANSGSSDGAGTDDAVRDRVTARLKSLLWKWTDAQGGGEDMSRPEAGGDTAPVSDDEMFDLIDKELGSL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more PKS_KR, PKS_KR, Acyl_transferase_dom, Acyl_transferase_dom, Acyl_transferase_dom, NorB/c/GfsB-D-like_docking, Ketoacyl_synth_N, Ketoacyl_synth_N, Ketoacyl_synth_C, Ketoacyl_synth_C, PKS_Beta-ketoAc_synthase_dom, PP-bd_ACP, Acyl_transferase_dom, Acyl_transferase_dom, PKS_mFAS_DH, PKS_DH, PKS_DH, PKS_Beta-ketoAc_synthase_dom, PKS_Beta-ketoAc_synthase_dom, PKS_assoc, PKS_assoc, PP-bd_ACP, PP-bd_ACP, SpnB-like_Rossmann, SpnB-like_Rossmann, PKS_DH_N, PKS_DH_N, PKS_PP-bd, PKS_PP-bd, PKS_DH_C, PKS_DH_C, PKS_Beta-ketoAc_synthase_dom, PP-bd_ACP, PKS_mFAS_DH that are essential for its biological function; 2. The protein should belong to PKS_NRPS_Biosynth_Enz that shares evolutionary origin and functional similarity; 3. The protein should be classified within ACP-like_sf, ACP-like_sf, Malonyl_transacylase_ACP-bd, Malonyl_transacylase_ACP-bd, NAD(P)-bd_dom_sf, ACP-like_sf, Thiolase-like, ACP-like_sf, Thiolase-like, Thiolase-like, Thiolase-like, NAD(P)-bd_dom_sf, Ac_transferase_dom_sf, Ac_transferase_dom_sf, NAD(P)-bd_dom_sf, Acyl_Trfase/lysoPLipase, NAD(P)-bd_dom_sf, Acyl_Trfase/lysoPLipase, PKS_dehydratase_sf, PKS_dehydratase_sf, Polyketide_synth_docking_sf sharing conserved structural features; 4. The protein must have Ketoacyl_synth_AS, Ketoacyl_synth_AS that is conserved among related catalytic enzymes; 5. The protein should contain Ppantetheine_attach_site, Ppantetheine_attach_site that allow regulation through chemical modifications. The designed protein sequence is ", "reference": "MDNEEKLVEYLKRVTADLRQVRRRLREVEDQQREPIAIIGMSCRFPGGIHTPEDLWDLVAGGQDAITSFPTDRGWDLDALLDPDPDRPGTSHTRHGAFLHDAPEFDAAFFDIGPSEATAMDPQQRLLLETSWEAFERAGIDPAALRGSRTGVFVGTNVHDYLTGVRETPQEVEGYLMTGNTPSVASGRLAYTFGLEGPAVTVDTACSASLVALHLAAHSLRRDECSLALAGGATVMSAPGAFVEFSRQGGLAADGRCKAFSASADGTGWGEGVGLLLLERLSDAERNGHPILAVVRGSAVNQDGASNGLTAPNGPSQQRVIRQALADARLSPADVDLVEAHGTGTQLGDPIEAQALLATYGQDRPEDRPLWLGSVKSNIGHTQAAAGAAGVIKTVMAMRHGVAPQTLHVDEPTPEVDWSAGAVELLTEARPWPAASAAGRPRRAAVSGFGVSGTNAHVILEQGPEQADTDPLPAQRQPLEDTVFPWALSARNTDALLGQARRLRERLVVEPGLSAADVAFSLGTVRSSFEQRAVVVGETRDELLAGLEALAEGREASGLVRGSARGSVNLGFLFSGQGSQRVGMGRELAERFPVFAGVFGEVCGLLDPLLPRPLGEVIAAGPGVLGRTVFTQPALFAVEVAAARLLLSWGVRPQVVAGHSVGEIAAAHVAGVLSLEDACALVAARGRLMEALPAGGVMVALEATEEEVAELLEAHAGAPVGVAAVNGPRAVVVSGDASPVGEIADVVRSWGRRTKRLEVSHAFHSPLMEPMLAEFTDVVTGLSFSAPRIGFVSAVTGGLVGADVVSRPEYWVEHVAQPVRFADAVRAAVDEAGVSLFVEVGPGGALSAMGPDCLDETVGDKQPVVFVPSLRADRPEPLAVTTALATAHVNGVQPDWQAVFAGTGAARVELPTYAFQRRRFWLDGGRYGNGGGVASAGLASAGHPLLGAVVEVAGDDRTLLSGRLSLASHPWLADHAVRGVVLVPGAAFVELALCAGERVGCGAVEELTLQAPLVLPVEGAVQVQFAVEAPDERGHRAFTVYGRSDEAAEPVSWQEYASGVLELEARPEPEGLAQWPPADAEAVPVESLYDLLRGLGYEYGPAFQGLRRVWRRGEELFAEVSLAEELDGQADQFGIHPALLDGALHTSAVALLEHDDADHREVTGVRLPFAWRGVSLFATGASAARVRLSPAGQDAVSVLVADQDGVPVARVEGLVSRPVAEEQLGAGGGVGRDSLFGVEWVPFAGGDSDALAADVLEVHRFDGLVQDPQGVREAIERALGLIQGWLARERPRGSRLVVVTRGAVGGEVSDLAGAAVWGLVRSAQSEHPGQFVLVDTDGDALAGLPADEPHVMVREGQVLVPRLARVVPATEGGAGGVVWDPEKSLLVTGASGVLAGLVVRHAVAEWAVRHVVLVSRSGADGLAQELAEAGVSVQQARCDVADREAVAAVLAGIPAEHRLGGVIHTAGVLDDGVIESLTPERLAPVLRPKVDGAWWLHELTADVDLSVFAVFSSAAGVFGAAGQGNYAAANAFLDALALYRHREGLPATSLSWGLWAERSGMAGQLADAQLERLERTGARPLSSSEGLALLDAALATGRPWLVPARLDLGVLRTSDQPVPPLLRGLVRRITRRAVTAGANGADSFVQRIAGLSPTEAERAVLELVCGETAAVLGHANAGAVPPGQAFQELGFDSLSAVELRNRLNSATGLRLPATLIFDYPTPAVLAAHIHSATAGTTAGPIAPLTVPGTAVDEAIAIVGMACRYPGGVASPEDLWRLVADGTDAISRFPQDRGWDLEGLFDPQRARGTSLTREGGFLYDADQFDAAFFGISPREALAMDPQQRLLLETSWEALERAGIDPATLRGSATGVFAGVMYHDYATRILEAPEEVEGYLANGNAGSIASGRVAYTFGLEGPAVTVDTACSSSLVTLHLAAQALRQGECSLALAGGVTVMATPGTFIEFSRQQGLSSDGRCKSFSATADGTGWSEGVGMLILERLSDAERNGHPILAVVRGSAVNQDGASNGLTAPNGPSQQRVIRQALANARLTPADIDLVEAHGTGTRLGDPIEAQALLATYGQDRTDDQPLWLGSIKSNIGHTQAAAGVAGIIKAVMAMRHGTLPASLHVDEPTPEVDWDAGAVELLTRARPWPTTDRPRRAAVSSFGISGTNAHVILEHATDTVPATDLTGTASPLSPAATVVPWVLSARGQDALRAQAQRLRDSLHDRPDPALADIGLSLATTRGALDDRAVVLGGDRQQMLDGLAALAAGEPSARLVLGQARPRPPRVVFVFPGQGSQWGGMAVELMDTCPVFAESIARCGQALAQVVDWDLEEVLRDGTFERVDVIQPVLWAVMVSLAELWRACGVRPDAVVGHSQGEIAAACVAGSLSVEDAARVVALRSRALLDLAGQGAMASVFASAEQTELLVAEAAGAAGAVGATGATGVTGEADAADREGRLSVAAVNGPESTVVSGETAAVEAFLDLCERRQIRARRIPVDYASHSAQVEAVADQVREALSGVTGRTGDVPLFSTVTGEWVDGEALDADYWLRNLRRPVRFHEAVRHLARQGHDLFIEVSPHPVLTMGLEDSVTAPGQATTPAADPTDTPTTATAPPGVVATLRRDEGDWSRFLASLAEVHAYGQPVNWAAVLGPARIVDLPTYAFQHRGYWLSDIGGRTPDVAAAGLDPARHPLLGAAVETAGGEQVLLTGRLSTGTHPWLADHVIGGTALLPVSAFVEMALRAGRHVGLPRLDELTLHTPLVVSAADVVRLQVQLDPDDGTGRRPVQIFARTADAPWVRHASGTLTGDAPADFGLLVWPPADATPLPVEGHYDHLAALGYAYGPSFQALRAAWRDGDDLYAEVALDTSENTADYGLHPILLDAAAQTLTLDHRADADTGARMPFAWTGVTLHAPGGGTARVKVSPAGDSAVTIRIADAAGQPVASVESLVLRPVSLQQIAAASSVTQNSLFLVDWTDIPAGPATTTGDTDRRPVLRSRDELEALRRAVADGQPAPALAAFICAAPGATEAPGTDALGNDLAQAVRATTADTLDALRAWLDDDRLEESRLAIVTCRAVVTGTDGAGAGGLNLAQTPVWGLVRSAQAENPGRFLLVDVDDLDAVPDVLARLEGPEGPEGLNEPQVAVRGGQFTVPRLVRPATPTPTADTDTAARDLDPDLDRWNPDGTVLLVGASGGLGQVLARHLVVERGVRRLVLTSRRGEAADGMAELRAELTEAGAVVDIAACDATDRDALAAVLDAIPERHPLTAVVHAAAVLDDGVVTALTPERLDRVLRPKVDTALLLDELTRGLDLGAFVLFSSLSSTLGSPGVANYAAANAFLDGLAQRRRDAGLPATSLAWGLWAQSGGMGDRLSDADLSRMSSGGVTALTTQEGLALFDRALTLDLPVVVPAKIDLAELRRLSGDLLPALLRGLVPGTVRTAAQTADVRTAPALAERLAALGEEERARALLDLVRSQAAAVLGHADVTAVQADTPFRDIGADSLAAVQIRNRLAAATGLRLKATLVFDHPTPAAVARLLLDELAPEPTDAQPAVFADLDALEATLAGLTEAGANSGSSDGAGTDDAVRDRVTARLKSLLWKWTDAQGGGEDMSRPEAGGDTAPVSDDEMFDLIDKELGSL" }, { "InterPro": [ { "InterPro-ID": "IPR014030", "InterPro-Name": "Ketoacyl_synth_N", "InterPro-Type": "DOMAIN", "Beg": 1750, "End": 1999 }, { "InterPro-ID": "IPR014030", "InterPro-Name": "Ketoacyl_synth_N", "InterPro-Type": "DOMAIN", "Beg": 34, "End": 284 }, { "InterPro-ID": "IPR036291", "InterPro-Name": "NAD(P)-bd_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 3137, "End": 3366 }, { "InterPro-ID": "IPR009081", "InterPro-Name": "PP-bd_ACP", "InterPro-Type": "DOMAIN", "Beg": 1652, "End": 1730 }, { "InterPro-ID": "IPR015083", "InterPro-Name": "NorB/c/GfsB-D-like_docking", "InterPro-Type": "DOMAIN", "Beg": 2, "End": 30 }, { "InterPro-ID": "IPR009081", "InterPro-Name": "PP-bd_ACP", "InterPro-Type": "DOMAIN", "Beg": 1660, "End": 1726 }, { "InterPro-ID": "IPR009081", "InterPro-Name": "PP-bd_ACP", "InterPro-Type": "DOMAIN", "Beg": 3429, "End": 3489 }, { "InterPro-ID": "IPR014043", "InterPro-Name": "Acyl_transferase_dom", "InterPro-Type": "DOMAIN", "Beg": 2284, "End": 2604 }, { "InterPro-ID": "IPR014043", "InterPro-Name": "Acyl_transferase_dom", "InterPro-Type": "DOMAIN", "Beg": 582, "End": 895 }, { "InterPro-ID": "IPR018201", "InterPro-Name": "Ketoacyl_synth_AS", "InterPro-Type": "ACTIVE_SITE", "Beg": 197, "End": 213 }, { "InterPro-ID": "IPR016039", "InterPro-Name": "Thiolase-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 30, "End": 400 }, { "InterPro-ID": "IPR016035", "InterPro-Name": "Acyl_Trfase/lysoPLipase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 579, "End": 860 }, { "InterPro-ID": "IPR014043", "InterPro-Name": "Acyl_transferase_dom", "InterPro-Type": "DOMAIN", "Beg": 583, "End": 876 }, { "InterPro-ID": "IPR014043", "InterPro-Name": "Acyl_transferase_dom", "InterPro-Type": "DOMAIN", "Beg": 2285, "End": 2587 }, { "InterPro-ID": "IPR049551", "InterPro-Name": "PKS_DH_C", "InterPro-Type": "DOMAIN", "Beg": 1069, "End": 1221 }, { "InterPro-ID": "IPR049551", "InterPro-Name": "PKS_DH_C", "InterPro-Type": "DOMAIN", "Beg": 2782, "End": 2934 }, { "InterPro-ID": "IPR036291", "InterPro-Name": "NAD(P)-bd_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 2944, "End": 3121 }, { "InterPro-ID": "IPR020841", "InterPro-Name": "PKS_Beta-ketoAc_synthase_dom", "InterPro-Type": "DOMAIN", "Beg": 1749, "End": 2174 }, { "InterPro-ID": "IPR006162", "InterPro-Name": "Ppantetheine_attach_site", "InterPro-Type": "PTM", "Beg": 3449, "End": 3464 }, { "InterPro-ID": "IPR050091", "InterPro-Name": "PKS_NRPS_Biosynth_Enz", "InterPro-Type": "FAMILY", "Beg": 1374, "End": 1728 }, { "InterPro-ID": "IPR036736", "InterPro-Name": "ACP-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1654, "End": 1765 }, { "InterPro-ID": "IPR006162", "InterPro-Name": "Ppantetheine_attach_site", "InterPro-Type": "PTM", "Beg": 1685, "End": 1700 }, { "InterPro-ID": "IPR016039", "InterPro-Name": "Thiolase-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1749, "End": 2122 }, { "InterPro-ID": "IPR036291", "InterPro-Name": "NAD(P)-bd_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1229, "End": 1363 }, { "InterPro-ID": "IPR036736", "InterPro-Name": "ACP-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1636, "End": 1734 }, { "InterPro-ID": "IPR036736", "InterPro-Name": "ACP-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 3400, "End": 3497 }, { "InterPro-ID": "IPR016039", "InterPro-Name": "Thiolase-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1742, "End": 2190 }, { "InterPro-ID": "IPR016039", "InterPro-Name": "Thiolase-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 25, "End": 487 }, { "InterPro-ID": "IPR036299", "InterPro-Name": "Polyketide_synth_docking_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 3, "End": 34 }, { "InterPro-ID": "IPR001031", "InterPro-Name": "Thioesterase", "InterPro-Type": "DOMAIN", "Beg": 3584, "End": 3794 }, { "InterPro-ID": "IPR049900", "InterPro-Name": "PKS_mFAS_DH", "InterPro-Type": "DOMAIN", "Beg": 944, "End": 1222 }, { "InterPro-ID": "IPR055123", "InterPro-Name": "SpnB-like_Rossmann", "InterPro-Type": "DOMAIN", "Beg": 1271, "End": 1338 }, { "InterPro-ID": "IPR055123", "InterPro-Name": "SpnB-like_Rossmann", "InterPro-Type": "DOMAIN", "Beg": 3002, "End": 3118 }, { "InterPro-ID": "IPR042104", "InterPro-Name": "PKS_dehydratase_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 933, "End": 1224 }, { "InterPro-ID": "IPR042104", "InterPro-Name": "PKS_dehydratase_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 2645, "End": 2938 }, { "InterPro-ID": "IPR020802", "InterPro-Name": "PKS_thioesterase", "InterPro-Type": "DOMAIN", "Beg": 3585, "End": 3795 }, { "InterPro-ID": "IPR029058", "InterPro-Name": "AB_hydrolase_fold", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 3524, "End": 3798 }, { "InterPro-ID": "IPR032821", "InterPro-Name": "PKS_assoc", "InterPro-Type": "DOMAIN", "Beg": 412, "End": 546 }, { "InterPro-ID": "IPR032821", "InterPro-Name": "PKS_assoc", "InterPro-Type": "DOMAIN", "Beg": 2127, "End": 2246 }, { "InterPro-ID": "IPR029058", "InterPro-Name": "AB_hydrolase_fold", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 3452, "End": 3795 }, { "InterPro-ID": "IPR020841", "InterPro-Name": "PKS_Beta-ketoAc_synthase_dom", "InterPro-Type": "DOMAIN", "Beg": 1752, "End": 2177 }, { "InterPro-ID": "IPR020841", "InterPro-Name": "PKS_Beta-ketoAc_synthase_dom", "InterPro-Type": "DOMAIN", "Beg": 36, "End": 462 }, { "InterPro-ID": "IPR009081", "InterPro-Name": "PP-bd_ACP", "InterPro-Type": "DOMAIN", "Beg": 3419, "End": 3494 }, { "InterPro-ID": "IPR016035", "InterPro-Name": "Acyl_Trfase/lysoPLipase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 2281, "End": 2577 }, { "InterPro-ID": "IPR036291", "InterPro-Name": "NAD(P)-bd_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1377, "End": 1617 }, { "InterPro-ID": "IPR049900", "InterPro-Name": "PKS_mFAS_DH", "InterPro-Type": "DOMAIN", "Beg": 2656, "End": 2936 }, { "InterPro-ID": "IPR020807", "InterPro-Name": "PKS_DH", "InterPro-Type": "DOMAIN", "Beg": 944, "End": 1107 }, { "InterPro-ID": "IPR020807", "InterPro-Name": "PKS_DH", "InterPro-Type": "DOMAIN", "Beg": 2656, "End": 2820 }, { "InterPro-ID": "IPR014031", "InterPro-Name": "Ketoacyl_synth_C", "InterPro-Type": "DOMAIN", "Beg": 292, "End": 409 }, { "InterPro-ID": "IPR014031", "InterPro-Name": "Ketoacyl_synth_C", "InterPro-Type": "DOMAIN", "Beg": 2007, "End": 2124 }, { "InterPro-ID": "IPR013968", "InterPro-Name": "PKS_KR", "InterPro-Type": "DOMAIN", "Beg": 3142, "End": 3314 }, { "InterPro-ID": "IPR013968", "InterPro-Name": "PKS_KR", "InterPro-Type": "DOMAIN", "Beg": 1382, "End": 1554 }, { "InterPro-ID": "IPR020806", "InterPro-Name": "PKS_PP-bd", "InterPro-Type": "DOMAIN", "Beg": 3422, "End": 3494 }, { "InterPro-ID": "IPR020806", "InterPro-Name": "PKS_PP-bd", "InterPro-Type": "DOMAIN", "Beg": 1658, "End": 1730 }, { "InterPro-ID": "IPR016036", "InterPro-Name": "Malonyl_transacylase_ACP-bd", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 2411, "End": 2478 }, { "InterPro-ID": "IPR016036", "InterPro-Name": "Malonyl_transacylase_ACP-bd", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 702, "End": 767 }, { "InterPro-ID": "IPR018201", "InterPro-Name": "Ketoacyl_synth_AS", "InterPro-Type": "ACTIVE_SITE", "Beg": 1912, "End": 1928 }, { "InterPro-ID": "IPR020841", "InterPro-Name": "PKS_Beta-ketoAc_synthase_dom", "InterPro-Type": "DOMAIN", "Beg": 33, "End": 459 }, { "InterPro-ID": "IPR049552", "InterPro-Name": "PKS_DH_N", "InterPro-Type": "DOMAIN", "Beg": 2656, "End": 2756 }, { "InterPro-ID": "IPR049552", "InterPro-Name": "PKS_DH_N", "InterPro-Type": "DOMAIN", "Beg": 944, "End": 1043 }, { "InterPro-ID": "IPR001227", "InterPro-Name": "Ac_transferase_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 581, "End": 879 }, { "InterPro-ID": "IPR001227", "InterPro-Name": "Ac_transferase_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 2283, "End": 2590 } ], "response#1": "MTNEDKLRDYLNRVMGELRQSRARLSESEARDHEPIAIIGMSCRFPDGVRSPEDLWRVLVDERHCLTDFPADRGWDLDALYHPDPGHSGTSYTRKGGFLHEAAGFDPEFFGISPREALAMDPQQRLLLETSWEVWERAGLDPAAMRGSRTGVFIGSNDLDYATRLRSVPDGVEGYLATGNLASVLSGRLSYTFGLEGPAVTVDTACSSSLVAMHLAAKALRSDECSLAMVGGVSVMAAPGTFLEFSRQRGLAQDGLCKAFADAADGTGMAEGVGVLLLERLSDARRNGHEVLAVLRGSAVNQDGASNGLTAPNGPSQEQVIRQALDNARLTPDSVDVVEAHGTGTRLGDPIEAEALLATYGQDRPEERPLWLGSVKSNIGHTQAAAGVAGVIKMVMALRQETLPATLHVDRPSTQVDWSSGAVSLLTEARPWARNGRPRRAGVSSFGVSGTNAHAILEEAPAATGNPTEADTDQEPAASASPDRTTTLPAVPWPLSGHTPEALRAQARRLHDTLTTVADGEPQPSPLDLGWSLATTRSTHRHRAVVVGADLPHLLQGVDALASGTPAPHLVRGVAGDTRTAFVFPGQGSQWAGMARELADSSPVFAERLRACEEALAPHVDWSLREVLDGSDLEKADVVQPVLWAVMVSLAALWESHGVRPDAVVGHSQGEIAAACVADALSLEDGARVVALRSRALGVLAGRGGMASLALSAEETTARLAAYKDRLSIAAVNGPHSTVVSGDVEPLHELVAACEADGVRARIVPVDYASHSAHVEEIHDTLLELLAPVTPRPSRVPFFSTVTGEWIDTTVMDAAYWYRNLRRTVQFDVATRTLIAEGFGLLIEASPHPVLAIGMQESVEAAAANCAVLGTLRRGEGGLDRYLLSLGEAHAHGADVDWPAVFAGTGAERVELPTYAFQRRRFWLDGGRDGAGGVASAGLASAGHPLFGAVVEVAGGDRTLLSGRLSVLSHPWLADHSVRGVVLVPGAAFVELALCAGERVGCGAVEELTLQAPLVLPVEGAVQVQFAVEAPDERGHRAFTVYGRSDEAAEPDAWQEYASGVLELEARPEPEGLAQWPPADAEVVPVEGLYDLLGGLGYEYGPAFQGLRRVWRRGEELFAEVSLAEELDGQADQFGIHPALLDGALQTSAVALLQHGGEAAEVRLPFAWRGVSLFATGASAARVRLSPAGQDAVSVLVADQDGVPVARVEGLVSRPVAEEQLGAGGGVGRDSLFGVEWVPFAGGDSDALAADVLEVHRFDGLVQDPQGVREAIERALGLIQGWLARERPRGSRLVVVTRGAVGGEVSDLAGAAVWGLVRSAQSEHPGQFVLVDTDGDALAGLPADEPHVMVREGQVLVPRLARVVPATEGGAGGVVWDPEKSLLVTGASGVLAGLVVRHAVAEWAVRHVVLVSRSGADGLAQELAEAGVSVQQARCDVADREAVAAVLAGIPAEHRLGGVIHTAGVLDDGVIESLTPERLEPVLRPKVDGAWWLHELTADVDLSVFAVFSSAAGVFGAAGQGNYAAANAFLDALALYRHREGLPATSLSWGLWAERSGLTGRLAESDLGRLSRQGVLPLSSEQGVALLDAVLATGRPWLVPARLDLGILRTSDQPVPPLLRGLVRRITRRAVTAGANGADSFVQRIAGLSPAEAERAVLELVCGEAAAVLGYASAGAVAPGQAFRELGFDSLTAVELRNRLNGATGLRLPATLIFDYPTPTALATHIRSSAAGTTTGPTAPVAIAGTAVDEAIAIVGMACRYPGGVASPEDLWRLVADEADAVSRFPQDRGWDLDALFDPERPGGTSLTREGGFLYDADQFDAAFFGISPREALAMDPQQRLLLETSWEALERAGIDPATLRGSATGVFAGVMYHDYGTRVLHVPEEVEGYLGNGNAGSIASGRVAYTFGLEGPAVTVDTACSSSLVTLHLASQALRQGECSLALAGGVTVLATPGVFTEFTRQRGLAEDGRCKAFAAAADGTGWGEGVGMLLLERLSDAERNGHPILAVVRGSAVNQDGASNGLTAPNGPSQQRVIRQALANARLTPADIDLVEAHGTGTRLGDPIEAQALLATYGQDRPEGEPAWLGSVKSNIGHTQAAAGVAGVIKSVMAIRNGVLPASLHVDEPTPEVDWDAGAVELLTEARPWPTTDRPRRAAVSSFGASGTNAHVILEQAADTGPVHAHEGDTTPPSVIAWPISGRDEQALREQAARLGAFVGADASLSAADVGNSLARTRASFEHRAVVVGRDRDELLAGVQALAAGEAAANVVTGRAPAEGAGRVAFVFPGQGSQWIGMGLELAEQSPVFAAALEECGQALAEHVDWDGRSLHEVLRQAEGAPSLERVDVVQPALWAVMVALAAAWRSYGIEPDAVVGHSQGEIAAACVAGVLSVEDGARVVAVRSRAITALAGRGQMVSVPLPEADTVELIRPWADDGQIAVAAVNGPASTVISGDSQAVDALLEKLDAQEIRARRIPVDYASHSPQVALIHDELLRVLDGLTPRAGTVPLFSTVTGQWLGATPMDADYWYRNLRETVRFEAGTRALAAEGWGVFVEASPHPVLTLGIQETLEALDHRGVVTGSLRRQEGGQDRLFVSLAKVHTHGGGPLDRPAFHTGTGAPRVDLPTYAFQRRRYWLEAPAGVPGDLSAAGLQTLEHPLLTGVVDLADEQRTVFTGRLSPATHPWLADHAVFGSVLLPGTGFVELALAAGEHVGHGHLDELTLHAPLFLPEEGAVHLQLVLDGPDTSGRRAVTIHSRAEDEAGGQEWTRHAGGTLAVDADHDTPPALTSWPPADADPVDLTEVYDRFAAAGYAYGPAFQGLRRVWRRDGELFAEVELAGPERDAARRFGVHPALLDAALHPLLLGHGAPQTESEGQGRLPFSWTGVSLRATGATTVRVRLTTDDADTVAVTVTDTAGTPVASVDALVTRPVTAAQFAAGRPSGQSGLFEVEWAPVPTPAAGTASWAVLGGGEVGGVGLGSYDDLAALRRAVDSGAPVPEVVLTFCGGRSETAVVPGTHTATREALALLHEWLADERFAGARLAVVTSGAVAAGPDDEVTDLAAAAVWGLVRSAQSEHPGRFVLLDVDGRAVAGAAVPTALATGEPQVAVRGGELLVPRLARAAKAREVGRDAAGVVWDPEKSLLVTGASGVLAGLTVRHAVSVWGVRHVVLLSRGGADALAQELSEVGVSVRQARCDVADREAVAAVLADIPAAHPLGGVIHTAGVLDDGVIESLTPERLEPVLRPKVDGAWWLHELTAGLDLSVFALFASGAGVFGAAGQGNYAAANAFLDALALHRSRKGLPATALSWGLWAERSGLTGQLTDAELNRMTHHGVLPLSSEQGLALLDSALATDRPWFVPVRIDLGAVRRTGFDHPLLRGLVRVPSRRTVAALDNGTPATDPASLWGRLVALSPAEQEAALLDLVGAQAAAVLGHTDPEQVTTDRPFLDLGFDSLTGVELRNRLTAATGLRLPTTLVFKHRTPAALAAQLRTDLVAVHTDGSGTDTAAPVEAARVPTNGGGTAEAFGELFVEAYRQGRSEEFFRLLRLASEFRPTFDAVRARESVPEPVRLAEGPAEGPDGPMLVCFPSVVGPSGPHQYARFAGPLRDRREVWAVAPPGFVQGELLPKDLATYTDATADAVARRVGETPFVLVGYSSGGWLAHAVASRMEEQGAAPAGVVLLDTYLPEGVVGQLGPELVGGLLERREKFRFDFGDDVWLTAMGGYFRLFDHWRPAAIKAPSLLVRSSEPMPGVPSDTDWRSRWDLPHTAVDVPGNHYTLMEDHAAETARAVRDWVGSLS", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Ketoacyl_synth_N, Ketoacyl_synth_N, PP-bd_ACP, NorB/c/GfsB-D-like_docking, PP-bd_ACP, PP-bd_ACP, Acyl_transferase_dom, Acyl_transferase_dom, Acyl_transferase_dom, Acyl_transferase_dom, PKS_DH_C, PKS_DH_C, PKS_Beta-ketoAc_synthase_dom, Thioesterase, PKS_mFAS_DH, SpnB-like_Rossmann, SpnB-like_Rossmann, PKS_thioesterase, PKS_assoc, PKS_assoc, PKS_Beta-ketoAc_synthase_dom, PKS_Beta-ketoAc_synthase_dom, PP-bd_ACP, PKS_mFAS_DH, PKS_DH, PKS_DH, Ketoacyl_synth_C, Ketoacyl_synth_C, PKS_KR, PKS_KR, PKS_PP-bd, PKS_PP-bd, PKS_Beta-ketoAc_synthase_dom, PKS_DH_N, PKS_DH_N that are essential for its biological function; 2. The protein should belong to PKS_NRPS_Biosynth_Enz that shares evolutionary origin and functional similarity; 3. The protein should be classified within NAD(P)-bd_dom_sf, Thiolase-like, Acyl_Trfase/lysoPLipase, NAD(P)-bd_dom_sf, ACP-like_sf, Thiolase-like, NAD(P)-bd_dom_sf, ACP-like_sf, ACP-like_sf, Thiolase-like, Thiolase-like, Polyketide_synth_docking_sf, PKS_dehydratase_sf, PKS_dehydratase_sf, AB_hydrolase_fold, AB_hydrolase_fold, Acyl_Trfase/lysoPLipase, NAD(P)-bd_dom_sf, Malonyl_transacylase_ACP-bd, Malonyl_transacylase_ACP-bd, Ac_transferase_dom_sf, Ac_transferase_dom_sf sharing conserved structural features; 4. The protein must have Ketoacyl_synth_AS, Ketoacyl_synth_AS that is conserved among related catalytic enzymes; 5. The protein should contain Ppantetheine_attach_site, Ppantetheine_attach_site that allow regulation through chemical modifications. The designed protein sequence is ", "reference": "MTNEDKLRDYLNRVMGELRQSRARLSESEARDHEPIAIIGMSCRFPDGVRSPEDLWRVLVDERHCLTDFPADRGWDLDALYHPDPGHSGTSYTRKGGFLHEAAGFDPEFFGISPREALAMDPQQRLLLETSWEVWERAGLDPAAMRGSRTGVFIGSNDLDYATRLRSVPDGVEGYLATGNLASVLSGRLSYTFGLEGPAVTVDTACSSSLVAMHLAAKALRSDECSLAMVGGVSVMAAPGTFLEFSRQRGLAQDGLCKAFADAADGTGMAEGVGVLLLERLSDARRNGHEVLAVLRGSAVNQDGASNGLTAPNGPSQEQVIRQALDNARLTPDSVDVVEAHGTGTRLGDPIEAEALLATYGQDRPEERPLWLGSVKSNIGHTQAAAGVAGVIKMVMALRQETLPATLHVDRPSTQVDWSSGAVSLLTEARPWARNGRPRRAGVSSFGVSGTNAHAILEEAPAATGNPTEADTDQEPAASASPDRTTTLPAVPWPLSGHTPEALRAQARRLHDTLTTVADGEPQPSPLDLGWSLATTRSTHRHRAVVVGADLPHLLQGVDALASGTPAPHLVRGVAGDTRTAFVFPGQGSQWAGMARELADSSPVFAERLRACEEALAPHVDWSLREVLDGSDLEKADVVQPVLWAVMVSLAALWESHGVRPDAVVGHSQGEIAAACVADALSLEDGARVVALRSRALGVLAGRGGMASLALSAEETTARLAAYKDRLSIAAVNGPHSTVVSGDVEPLHELVAACEADGVRARIVPVDYASHSAHVEEIHDTLLELLAPVTPRPSRVPFFSTVTGEWIDTTVMDAAYWYRNLRRTVQFDVATRTLIAEGFGLLIEASPHPVLAIGMQESVEAAAANCAVLGTLRRGEGGLDRYLLSLGEAHAHGADVDWPAVFAGTGAERVELPTYAFQRRRFWLDGGRDGAGGVASAGLASAGHPLFGAVVEVAGGDRTLLSGRLSVLSHPWLADHSVRGVVLVPGAAFVELALCAGERVGCGAVEELTLQAPLVLPVEGAVQVQFAVEAPDERGHRAFTVYGRSDEAAEPDAWQEYASGVLELEARPEPEGLAQWPPADAEVVPVEGLYDLLGGLGYEYGPAFQGLRRVWRRGEELFAEVSLAEELDGQADQFGIHPALLDGALQTSAVALLQHGGEAAEVRLPFAWRGVSLFATGASAARVRLSPAGQDAVSVLVADQDGVPVARVEGLVSRPVAEEQLGAGGGVGRDSLFGVEWVPFAGGDSDALAADVLEVHRFDGLVQDPQGVREAIERALGLIQGWLARERPRGSRLVVVTRGAVGGEVSDLAGAAVWGLVRSAQSEHPGQFVLVDTDGDALAGLPADEPHVMVREGQVLVPRLARVVPATEGGAGGVVWDPEKSLLVTGASGVLAGLVVRHAVAEWAVRHVVLVSRSGADGLAQELAEAGVSVQQARCDVADREAVAAVLAGIPAEHRLGGVIHTAGVLDDGVIESLTPERLEPVLRPKVDGAWWLHELTADVDLSVFAVFSSAAGVFGAAGQGNYAAANAFLDALALYRHREGLPATSLSWGLWAERSGLTGRLAESDLGRLSRQGVLPLSSEQGVALLDAVLATGRPWLVPARLDLGILRTSDQPVPPLLRGLVRRITRRAVTAGANGADSFVQRIAGLSPAEAERAVLELVCGEAAAVLGYASAGAVAPGQAFRELGFDSLTAVELRNRLNGATGLRLPATLIFDYPTPTALATHIRSSAAGTTTGPTAPVAIAGTAVDEAIAIVGMACRYPGGVASPEDLWRLVADEADAVSRFPQDRGWDLDALFDPERPGGTSLTREGGFLYDADQFDAAFFGISPREALAMDPQQRLLLETSWEALERAGIDPATLRGSATGVFAGVMYHDYGTRVLHVPEEVEGYLGNGNAGSIASGRVAYTFGLEGPAVTVDTACSSSLVTLHLASQALRQGECSLALAGGVTVLATPGVFTEFTRQRGLAEDGRCKAFAAAADGTGWGEGVGMLLLERLSDAERNGHPILAVVRGSAVNQDGASNGLTAPNGPSQQRVIRQALANARLTPADIDLVEAHGTGTRLGDPIEAQALLATYGQDRPEGEPAWLGSVKSNIGHTQAAAGVAGVIKSVMAIRNGVLPASLHVDEPTPEVDWDAGAVELLTEARPWPTTDRPRRAAVSSFGASGTNAHVILEQAADTGPVHAHEGDTTPPSVIAWPISGRDEQALREQAARLGAFVGADASLSAADVGNSLARTRASFEHRAVVVGRDRDELLAGVQALAAGEAAANVVTGRAPAEGAGRVAFVFPGQGSQWIGMGLELAEQSPVFAAALEECGQALAEHVDWDGRSLHEVLRQAEGAPSLERVDVVQPALWAVMVALAAAWRSYGIEPDAVVGHSQGEIAAACVAGVLSVEDGARVVAVRSRAITALAGRGQMVSVPLPEADTVELIRPWADDGQIAVAAVNGPASTVISGDSQAVDALLEKLDAQEIRARRIPVDYASHSPQVALIHDELLRVLDGLTPRAGTVPLFSTVTGQWLGATPMDADYWYRNLRETVRFEAGTRALAAEGWGVFVEASPHPVLTLGIQETLEALDHRGVVTGSLRRQEGGQDRLFVSLAKVHTHGGGPLDRPAFHTGTGAPRVDLPTYAFQRRRYWLEAPAGVPGDLSAAGLQTLEHPLLTGVVDLADEQRTVFTGRLSPATHPWLADHAVFGSVLLPGTGFVELALAAGEHVGHGHLDELTLHAPLFLPEEGAVHLQLVLDGPDTSGRRAVTIHSRAEDEAGGQEWTRHAGGTLAVDADHDTPPALTSWPPADADPVDLTEVYDRFAAAGYAYGPAFQGLRRVWRRDGELFAEVELAGPERDAARRFGVHPALLDAALHPLLLGHGAPQTESEGQGRLPFSWTGVSLRATGATTVRVRLTTDDADTVAVTVTDTAGTPVASVDALVTRPVTAAQFAAGRPSGQSGLFEVEWAPVPTPAAGTASWAVLGGGEVGGVGLGSYDDLAALRRAVDSGAPVPEVVLTFCGGRSETAVVPGTHTATREALALLHEWLADERFAGARLAVVTSGAVAAGPDDEVTDLAAAAVWGLVRSAQSEHPGRFVLLDVDGRAVAGAAVPTALATGEPQVAVRGGELLVPRLARAAKAREVGRDAAGVVWDPEKSLLVTGASGVLAGLTVRHAVSVWGVRHVVLLSRGGADALAQELSEVGVSVRQARCDVADREAVAAVLADIPAAHPLGGVIHTAGVLDDGVIESLTPERLEPVLRPKVDGAWWLHELTAGLDLSVFALFASGAGVFGAAGQGNYAAANAFLDALALHRSRKGLPATALSWGLWAERSGLTGQLTDAELNRMTHHGVLPLSSEQGLALLDSALATDRPWFVPVRIDLGAVRRTGFDHPLLRGLVRVPSRRTVAALDNGTPATDPASLWGRLVALSPAEQEAALLDLVGAQAAAVLGHTDPEQVTTDRPFLDLGFDSLTGVELRNRLTAATGLRLPTTLVFKHRTPAALAAQLRTDLVAVHTDGSGTDTAAPVEAARVPTNGGGTAEAFGELFVEAYRQGRSEEFFRLLRLASEFRPTFDAVRARESVPEPVRLAEGPAEGPDGPMLVCFPSVVGPSGPHQYARFAGPLRDRREVWAVAPPGFVQGELLPKDLATYTDATADAVARRVGETPFVLVGYSSGGWLAHAVASRMEEQGAAPAGVVLLDTYLPEGVVGQLGPELVGGLLERREKFRFDFGDDVWLTAMGGYFRLFDHWRPAAIKAPSLLVRSSEPMPGVPSDTDWRSRWDLPHTAVDVPGNHYTLMEDHAAETARAVRDWVGSLS" }, { "InterPro": [ { "InterPro-ID": "IPR036574", "InterPro-Name": "Scorpion_toxin-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 21, "End": 83 }, { "InterPro-ID": "IPR044062", "InterPro-Name": "LCN-type_CS_alpha_beta_dom", "InterPro-Type": "DOMAIN", "Beg": 21, "End": 83 }, { "InterPro-ID": "IPR036574", "InterPro-Name": "Scorpion_toxin-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 22, "End": 83 }, { "InterPro-ID": "IPR003614", "InterPro-Name": "Scorpion_toxin-like", "InterPro-Type": "DOMAIN", "Beg": 20, "End": 70 }, { "InterPro-ID": "IPR002061", "InterPro-Name": "Scorpion_toxinL/defensin", "InterPro-Type": "FAMILY", "Beg": 23, "End": 70 }, { "InterPro-ID": "IPR018218", "InterPro-Name": "Scorpion_toxinL", "InterPro-Type": "FAMILY", "Beg": 51, "End": 61 }, { "InterPro-ID": "IPR018218", "InterPro-Name": "Scorpion_toxinL", "InterPro-Type": "FAMILY", "Beg": 40, "End": 47 }, { "InterPro-ID": "IPR018218", "InterPro-Name": "Scorpion_toxinL", "InterPro-Type": "FAMILY", "Beg": 63, "End": 76 }, { "InterPro-ID": "IPR018218", "InterPro-Name": "Scorpion_toxinL", "InterPro-Type": "FAMILY", "Beg": 31, "End": 38 } ], "response#1": "MMKTVIVLIVFSLVMIVVKSDNGYLLDKYTGCKIWCVINNDSCNSHCIGSGGYYGYCYFWKLACYCQGAPRSELWHYETNRCRA", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more LCN-type_CS_alpha_beta_dom, Scorpion_toxin-like that are essential for its biological function; 2. The protein should belong to Scorpion_toxinL/defensin, Scorpion_toxinL, Scorpion_toxinL, Scorpion_toxinL, Scorpion_toxinL that shares evolutionary origin and functional similarity; 3. The protein should be classified within Scorpion_toxin-like_sf, Scorpion_toxin-like_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MMKTVIVLIVFSLVMIVVKSDNGYLLDKYTGCKIWCVINNDSCNSHCIGSGGYYGYCYFWKLACYCQGAPRSELWHYETNRCRA" }, { "InterPro": [ { "InterPro-ID": "IPR001064", "InterPro-Name": "Beta/gamma_crystallin", "InterPro-Type": "DOMAIN", "Beg": 3, "End": 84 }, { "InterPro-ID": "IPR001064", "InterPro-Name": "Beta/gamma_crystallin", "InterPro-Type": "DOMAIN", "Beg": 43, "End": 84 }, { "InterPro-ID": "IPR001064", "InterPro-Name": "Beta/gamma_crystallin", "InterPro-Type": "DOMAIN", "Beg": 2, "End": 42 }, { "InterPro-ID": "IPR001064", "InterPro-Name": "Beta/gamma_crystallin", "InterPro-Type": "DOMAIN", "Beg": 3, "End": 82 }, { "InterPro-ID": "IPR011024", "InterPro-Name": "G_crystallin-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1, "End": 82 }, { "InterPro-ID": "IPR050252", "InterPro-Name": "Beta/Gamma-Crystallin", "InterPro-Type": "FAMILY", "Beg": 2, "End": 81 } ], "response#1": "MGKIILFEDVEFGGKKLELETSVSDLNVHGFNDIVSSIIVESGTWFVFDDEGFSGPSYKLTPGKYPNPGSWGGNDDELSSVKQQ", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Beta/gamma_crystallin, Beta/gamma_crystallin, Beta/gamma_crystallin, Beta/gamma_crystallin that are essential for its biological function; 2. The protein should belong to Beta/Gamma-Crystallin that shares evolutionary origin and functional similarity; 3. The protein should be classified within G_crystallin-like sharing conserved structural features. The designed protein sequence is ", "reference": "MGKIILFEDVEFGGKKLELETSVSDLNVHGFNDIVSSIIVESGTWFVFDDEGFSGPSYKLTPGKYPNPGSWGGNDDELSSVKQQ" }, { "InterPro": [ { "InterPro-ID": "IPR001932", "InterPro-Name": "PPM-type_phosphatase-like_dom", "InterPro-Type": "DOMAIN", "Beg": 23, "End": 294 }, { "InterPro-ID": "IPR015655", "InterPro-Name": "PP2C", "InterPro-Type": "FAMILY", "Beg": 18, "End": 291 }, { "InterPro-ID": "IPR001932", "InterPro-Name": "PPM-type_phosphatase-like_dom", "InterPro-Type": "DOMAIN", "Beg": 37, "End": 294 }, { "InterPro-ID": "IPR001932", "InterPro-Name": "PPM-type_phosphatase-like_dom", "InterPro-Type": "DOMAIN", "Beg": 13, "End": 292 }, { "InterPro-ID": "IPR036457", "InterPro-Name": "PPM-type-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 3, "End": 294 }, { "InterPro-ID": "IPR000222", "InterPro-Name": "PP2C_BS", "InterPro-Type": "BINDING_SITE", "Beg": 62, "End": 70 }, { "InterPro-ID": "IPR036457", "InterPro-Name": "PPM-type-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1, "End": 302 }, { "InterPro-ID": "IPR001932", "InterPro-Name": "PPM-type_phosphatase-like_dom", "InterPro-Type": "DOMAIN", "Beg": 24, "End": 278 } ], "response#1": "MGQTLSEPVVEKTSEKGEDDRLIYGVSAMQGWRISMEDAHTAELNLPPPDNDTKTHPDRLSFFGVFDGHGGDKVALFAGENIHNIVFKQESFKSGDYAQGLKDGFLATDRAILNDPKYEEEVSGCTACVTLIAGNKLYVANAGDSRSVLGIKGRAKPLSNDHKPQLETEKNRITAAGGFVDFGRVNGNLALSRAIGDFEFKKSAELSPENQIVTAFPDVEVHELTEEDEFLVIACDGIWDCQSSQAVVEFVRRGIAAKQDLDKICENMMDNCLASNSETGGVGCDNMTMVIIGFLHGKTKEEWYDEIAKRVANGDGPCAPPEYAEFRGPGVHHNYEDSDSGYDVDADSGGKFSLAGSRGRIIFLGDGTEVLTGSDDTEMFDNADEDKDLASQVPKSSGKTDAKEETEAKPAPEAESSKPADGSEKKQDEKTPEESKKD", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more PPM-type_phosphatase-like_dom, PPM-type_phosphatase-like_dom, PPM-type_phosphatase-like_dom, PPM-type_phosphatase-like_dom that are essential for its biological function; 2. The protein should belong to PP2C that shares evolutionary origin and functional similarity; 3. The protein should be classified within PPM-type-like_dom_sf, PPM-type-like_dom_sf sharing conserved structural features; 4. The protein should include a PP2C_BS that enables ligand binding under diverse conditions. The designed protein sequence is ", "reference": "MGQTLSEPVVEKTSEKGEDDRLIYGVSAMQGWRISMEDAHTAELNLPPPDNDTKTHPDRLSFFGVFDGHGGDKVALFAGENIHNIVFKQESFKSGDYAQGLKDGFLATDRAILNDPKYEEEVSGCTACVTLIAGNKLYVANAGDSRSVLGIKGRAKPLSNDHKPQLETEKNRITAAGGFVDFGRVNGNLALSRAIGDFEFKKSAELSPENQIVTAFPDVEVHELTEEDEFLVIACDGIWDCQSSQAVVEFVRRGIAAKQDLDKICENMMDNCLASNSETGGVGCDNMTMVIIGFLHGKTKEEWYDEIAKRVANGDGPCAPPEYAEFRGPGVHHNYEDSDSGYDVDADSGGKFSLAGSRGRIIFLGDGTEVLTGSDDTEMFDNADEDKDLASQVPKSSGKTDAKEETEAKPAPEAESSKPADGSEKKQDEKTPEESKKD" }, { "InterPro": [ { "InterPro-ID": "IPR011989", "InterPro-Name": "ARM-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 25, "End": 338 }, { "InterPro-ID": "IPR011989", "InterPro-Name": "ARM-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 339, "End": 676 }, { "InterPro-ID": "IPR016024", "InterPro-Name": "ARM-type_fold", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 39, "End": 467 }, { "InterPro-ID": "IPR052616", "InterPro-Name": "Nuclear_Import_Ribosome_Adapt", "InterPro-Type": "FAMILY", "Beg": 1, "End": 674 } ], "response#1": "MGKTRRNRVRNRTDPIAKPVKPPTDPELAKLREDKILPVLKDLKSPDAKSRTTAAGAIANIVQDAKCRKLLLREQVVHIVLTETLTDNNIDSRAAGWEILKVLAQEEEADFCVHLYRLDVLTAIEHAAKAVLETLTTSEPPFSKLLKAQQRLVWDITGSLLVLIGLLALARDEIHEAVATKQTILRLLFRLISADIAPQDIYEEAISCLTTLSEDNLKVGQAITDDQETHVYDVLLKLATGTDPRAVMACGVLHNVFTSLQWMDHSPGKDGACDAILIPTLTRALEHVVPGGAKFNGDARYANITLLALVTLASIGTDFQETLVKGNQGSRESPISAADEEWNGFDDADGDAMDVDQKSSSGEDQEEDYEEIDVKEDDEDDDDDSITSEMQADMERVVGADGTDDGDLEDLPTLRELIQTAVPQLIRLSNLPIDSDESLTIQSHALSALNNISWTISCLEFANGENANIHNAWYPTAKKIWRKTILPILEADSADLKLATQVTSLAWAVARVLHGETPTDGNPHRKFISLYHSSKQQAGGNSNSIEEPEDPFQGLGVKCIGVVGSLAHDPAPIEVNREVGVFLVTLLRQSNNVPPAEIVEALNQLFDIYGDEELACDKEVFWKDGFLKHLEEFLPKMRTLTKGIDKRTQPELRTRADEALLNLGRFVQYKKKHAPK", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Nuclear_Import_Ribosome_Adapt that shares evolutionary origin and functional similarity; 2. The protein should be classified within ARM-like, ARM-like, ARM-type_fold sharing conserved structural features. The designed protein sequence is ", "reference": "MGKTRRNRVRNRTDPIAKPVKPPTDPELAKLREDKILPVLKDLKSPDAKSRTTAAGAIANIVQDAKCRKLLLREQVVHIVLTETLTDNNIDSRAAGWEILKVLAQEEEADFCVHLYRLDVLTAIEHAAKAVLETLTTSEPPFSKLLKAQQRLVWDITGSLLVLIGLLALARDEIHEAVATKQTILRLLFRLISADIAPQDIYEEAISCLTTLSEDNLKVGQAITDDQETHVYDVLLKLATGTDPRAVMACGVLHNVFTSLQWMDHSPGKDGACDAILIPTLTRALEHVVPGGAKFNGDARYANITLLALVTLASIGTDFQETLVKGNQGSRESPISAADEEWNGFDDADGDAMDVDQKSSSGEDQEEDYEEIDVKEDDEDDDDDSITSEMQADMERVVGADGTDDGDLEDLPTLRELIQTAVPQLIRLSNLPIDSDESLTIQSHALSALNNISWTISCLEFANGENANIHNAWYPTAKKIWRKTILPILEADSADLKLATQVTSLAWAVARVLHGETPTDGNPHRKFISLYHSSKQQAGGNSNSIEEPEDPFQGLGVKCIGVVGSLAHDPAPIEVNREVGVFLVTLLRQSNNVPPAEIVEALNQLFDIYGDEELACDKEVFWKDGFLKHLEEFLPKMRTLTKGIDKRTQPELRTRADEALLNLGRFVQYKKKHAPK" }, { "InterPro": [ { "InterPro-ID": "IPR036574", "InterPro-Name": "Scorpion_toxin-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1, "End": 66 }, { "InterPro-ID": "IPR003614", "InterPro-Name": "Scorpion_toxin-like", "InterPro-Type": "DOMAIN", "Beg": 1, "End": 51 }, { "InterPro-ID": "IPR018218", "InterPro-Name": "Scorpion_toxinL", "InterPro-Type": "FAMILY", "Beg": 35, "End": 45 }, { "InterPro-ID": "IPR018218", "InterPro-Name": "Scorpion_toxinL", "InterPro-Type": "FAMILY", "Beg": 11, "End": 18 }, { "InterPro-ID": "IPR018218", "InterPro-Name": "Scorpion_toxinL", "InterPro-Type": "FAMILY", "Beg": 45, "End": 58 }, { "InterPro-ID": "IPR018218", "InterPro-Name": "Scorpion_toxinL", "InterPro-Type": "FAMILY", "Beg": 22, "End": 29 }, { "InterPro-ID": "IPR044062", "InterPro-Name": "LCN-type_CS_alpha_beta_dom", "InterPro-Type": "DOMAIN", "Beg": 1, "End": 66 } ], "response#1": "KEGYIVNYYDGCKYACAKLGDNDYCLRECKARYGKGAGGYCYAFGCWCTHLYEQAVVWPLPKKKCN", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Scorpion_toxin-like, LCN-type_CS_alpha_beta_dom that are essential for its biological function; 2. The protein should belong to Scorpion_toxinL, Scorpion_toxinL, Scorpion_toxinL, Scorpion_toxinL that shares evolutionary origin and functional similarity; 3. The protein should be classified within Scorpion_toxin-like_sf sharing conserved structural features. The designed protein sequence is ", "reference": "KEGYIVNYYDGCKYACAKLGDNDYCLRECKARYGKGAGGYCYAFGCWCTHLYEQAVVWPLPKKKCN" }, { "InterPro": [ { "InterPro-ID": "IPR000485", "InterPro-Name": "AsnC-type_HTH_dom", "InterPro-Type": "DOMAIN", "Beg": 32, "End": 48 }, { "InterPro-ID": "IPR000485", "InterPro-Name": "AsnC-type_HTH_dom", "InterPro-Type": "DOMAIN", "Beg": 59, "End": 78 }, { "InterPro-ID": "IPR000485", "InterPro-Name": "AsnC-type_HTH_dom", "InterPro-Type": "DOMAIN", "Beg": 48, "End": 59 }, { "InterPro-ID": "IPR019888", "InterPro-Name": "Tscrpt_reg_AsnC-like", "InterPro-Type": "FAMILY", "Beg": 32, "End": 141 }, { "InterPro-ID": "IPR036390", "InterPro-Name": "WH_DNA-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 32, "End": 91 }, { "InterPro-ID": "IPR011991", "InterPro-Name": "ArsR-like_HTH", "InterPro-Type": "DOMAIN", "Beg": 33, "End": 79 }, { "InterPro-ID": "IPR036388", "InterPro-Name": "WH-like_DNA-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 35, "End": 84 }, { "InterPro-ID": "IPR000485", "InterPro-Name": "AsnC-type_HTH_dom", "InterPro-Type": "DOMAIN", "Beg": 32, "End": 93 }, { "InterPro-ID": "IPR019887", "InterPro-Name": "Tscrpt_reg_AsnC/Lrp_C", "InterPro-Type": "DOMAIN", "Beg": 100, "End": 171 }, { "InterPro-ID": "IPR011008", "InterPro-Name": "Dimeric_a/b-barrel", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 92, "End": 173 } ], "response#1": "MIILFRGHMRDNSTEHKTRRAASSKDVRPAELDEVDRRILSLLHGDARMPNNALADTVGIAPSTCHGRVRRLVDLGVIRGFYTDIDPVAVGLPLQAMISVNLQSSARGKIRSFIQQIRRKRQVMDVYFLAGADDFILHVAARDTEDLRSFVVENLNADADVAGTQTSLIFEHLRGAAPI", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more AsnC-type_HTH_dom, AsnC-type_HTH_dom, AsnC-type_HTH_dom, ArsR-like_HTH, AsnC-type_HTH_dom, Tscrpt_reg_AsnC/Lrp_C that are essential for its biological function; 2. The protein should belong to Tscrpt_reg_AsnC-like that shares evolutionary origin and functional similarity; 3. The protein should be classified within WH_DNA-bd_sf, WH-like_DNA-bd_sf, Dimeric_a/b-barrel sharing conserved structural features. The designed protein sequence is ", "reference": "MIILFRGHMRDNSTEHKTRRAASSKDVRPAELDEVDRRILSLLHGDARMPNNALADTVGIAPSTCHGRVRRLVDLGVIRGFYTDIDPVAVGLPLQAMISVNLQSSARGKIRSFIQQIRRKRQVMDVYFLAGADDFILHVAARDTEDLRSFVVENLNADADVAGTQTSLIFEHLRGAAPI" }, { "InterPro": [ { "InterPro-ID": "IPR001077", "InterPro-Name": "O_MeTrfase_dom", "InterPro-Type": "DOMAIN", "Beg": 219, "End": 361 }, { "InterPro-ID": "IPR029063", "InterPro-Name": "SAM-dependent_MTases_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 143, "End": 382 }, { "InterPro-ID": "IPR016461", "InterPro-Name": "COMT-like", "InterPro-Type": "FAMILY", "Beg": 42, "End": 381 }, { "InterPro-ID": "IPR036388", "InterPro-Name": "WH-like_DNA-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 35, "End": 117 }, { "InterPro-ID": "IPR016461", "InterPro-Name": "COMT-like", "InterPro-Type": "FAMILY", "Beg": 33, "End": 114 }, { "InterPro-ID": "IPR016461", "InterPro-Name": "COMT-like", "InterPro-Type": "FAMILY", "Beg": 215, "End": 382 }, { "InterPro-ID": "IPR036390", "InterPro-Name": "WH_DNA-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 37, "End": 120 }, { "InterPro-ID": "IPR029063", "InterPro-Name": "SAM-dependent_MTases_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 155, "End": 378 } ], "response#1": "MEAIAQEIQKLHANTDEAGRGKINHDLSVLLASFDTDWEKILKLAAGPLRLALVKVGVDQGIFHALNERSHTLPELIEKTGVAPYLLERILRGQASFGMIKEEGAKGFAANRFTTLLAGPNTSGAVTYIFDILRPIASAIPGFLSERNNPAITSTHDTVFQRAFNTELGGFEWMTGHPEHYGNLFQFLALRPNCEWVDAFPIEAEIGSFTNDPHVEKVLLVDVGGGTGAQSVAFRKKLPHVKGRVIVQEIAETLIHVGAKAPAGIEFMEYDCFTPQPIRGAKFYYLRYVMHLWQDERCVEALKVIITAMGPESRLIIDEAVIPDRDVPWQAACQSILMTAALAGAERTLTEWHNLLDAAGLKILNIFPYDLNMQSVIIAVPK", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more O_MeTrfase_dom that are essential for its biological function; 2. The protein should belong to COMT-like, COMT-like, COMT-like that shares evolutionary origin and functional similarity; 3. The protein should be classified within SAM-dependent_MTases_sf, WH-like_DNA-bd_sf, WH_DNA-bd_sf, SAM-dependent_MTases_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MEAIAQEIQKLHANTDEAGRGKINHDLSVLLASFDTDWEKILKLAAGPLRLALVKVGVDQGIFHALNERSHTLPELIEKTGVAPYLLERILRGQASFGMIKEEGAKGFAANRFTTLLAGPNTSGAVTYIFDILRPIASAIPGFLSERNNPAITSTHDTVFQRAFNTELGGFEWMTGHPEHYGNLFQFLALRPNCEWVDAFPIEAEIGSFTNDPHVEKVLLVDVGGGTGAQSVAFRKKLPHVKGRVIVQEIAETLIHVGAKAPAGIEFMEYDCFTPQPIRGAKFYYLRYVMHLWQDERCVEALKVIITAMGPESRLIIDEAVIPDRDVPWQAACQSILMTAALAGAERTLTEWHNLLDAAGLKILNIFPYDLNMQSVIIAVPK" }, { "InterPro": [ { "InterPro-ID": "IPR029063", "InterPro-Name": "SAM-dependent_MTases_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1422, "End": 1601 }, { "InterPro-ID": "IPR014031", "InterPro-Name": "Ketoacyl_synth_C", "InterPro-Type": "DOMAIN", "Beg": 271, "End": 387 }, { "InterPro-ID": "IPR020843", "InterPro-Name": "PKS_ER", "InterPro-Type": "DOMAIN", "Beg": 1853, "End": 2154 }, { "InterPro-ID": "IPR020806", "InterPro-Name": "PKS_PP-bd", "InterPro-Type": "DOMAIN", "Beg": 2491, "End": 2546 }, { "InterPro-ID": "IPR042104", "InterPro-Name": "PKS_dehydratase_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 927, "End": 1236 }, { "InterPro-ID": "IPR049551", "InterPro-Name": "PKS_DH_C", "InterPro-Type": "DOMAIN", "Beg": 1096, "End": 1191 }, { "InterPro-ID": "IPR011032", "InterPro-Name": "GroES-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1847, "End": 1982 }, { "InterPro-ID": "IPR032821", "InterPro-Name": "PKS_assoc", "InterPro-Type": "DOMAIN", "Beg": 391, "End": 514 }, { "InterPro-ID": "IPR014043", "InterPro-Name": "Acyl_transferase_dom", "InterPro-Type": "DOMAIN", "Beg": 549, "End": 877 }, { "InterPro-ID": "IPR036736", "InterPro-Name": "ACP-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 2489, "End": 2560 }, { "InterPro-ID": "IPR009081", "InterPro-Name": "PP-bd_ACP", "InterPro-Type": "DOMAIN", "Beg": 2485, "End": 2563 }, { "InterPro-ID": "IPR020807", "InterPro-Name": "PKS_DH", "InterPro-Type": "DOMAIN", "Beg": 942, "End": 1117 }, { "InterPro-ID": "IPR036291", "InterPro-Name": "NAD(P)-bd_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 2175, "End": 2395 }, { "InterPro-ID": "IPR020841", "InterPro-Name": "PKS_Beta-ketoAc_synthase_dom", "InterPro-Type": "DOMAIN", "Beg": 9, "End": 437 }, { "InterPro-ID": "IPR001227", "InterPro-Name": "Ac_transferase_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 546, "End": 847 }, { "InterPro-ID": "IPR020841", "InterPro-Name": "PKS_Beta-ketoAc_synthase_dom", "InterPro-Type": "DOMAIN", "Beg": 12, "End": 440 }, { "InterPro-ID": "IPR014030", "InterPro-Name": "Ketoacyl_synth_N", "InterPro-Type": "DOMAIN", "Beg": 10, "End": 262 }, { "InterPro-ID": "IPR016039", "InterPro-Name": "Thiolase-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 8, "End": 383 }, { "InterPro-ID": "IPR014043", "InterPro-Name": "Acyl_transferase_dom", "InterPro-Type": "DOMAIN", "Beg": 550, "End": 860 }, { "InterPro-ID": "IPR016035", "InterPro-Name": "Acyl_Trfase/lysoPLipase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 546, "End": 845 }, { "InterPro-ID": "IPR018201", "InterPro-Name": "Ketoacyl_synth_AS", "InterPro-Type": "ACTIVE_SITE", "Beg": 175, "End": 191 }, { "InterPro-ID": "IPR029063", "InterPro-Name": "SAM-dependent_MTases_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1279, "End": 1596 }, { "InterPro-ID": "IPR049900", "InterPro-Name": "PKS_mFAS_DH", "InterPro-Type": "DOMAIN", "Beg": 942, "End": 1244 }, { "InterPro-ID": "IPR036291", "InterPro-Name": "NAD(P)-bd_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1960, "End": 2128 }, { "InterPro-ID": "IPR013217", "InterPro-Name": "Methyltransf_12", "InterPro-Type": "DOMAIN", "Beg": 1430, "End": 1535 }, { "InterPro-ID": "IPR013968", "InterPro-Name": "PKS_KR", "InterPro-Type": "DOMAIN", "Beg": 2177, "End": 2357 }, { "InterPro-ID": "IPR050091", "InterPro-Name": "PKS_NRPS_Biosynth_Enz", "InterPro-Type": "FAMILY", "Beg": 11, "End": 2548 }, { "InterPro-ID": "IPR049552", "InterPro-Name": "PKS_DH_N", "InterPro-Type": "DOMAIN", "Beg": 942, "End": 1048 }, { "InterPro-ID": "IPR016036", "InterPro-Name": "Malonyl_transacylase_ACP-bd", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 677, "End": 737 }, { "InterPro-ID": "IPR016039", "InterPro-Name": "Thiolase-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 9, "End": 521 } ], "response#1": "MAPQNNGYPEPIAIVGMACRLPGEVTSPSKLWDLLVEERSAQSDVPSNRFNVDSWYHPDKTRPGSISTRGGYFLSEDDSYRQFDPFFFGINPKEAASMDPQQRKLLEVVYESFEAAGARLEDVSGSKTACYVGNFTWDIGQMQARDVNHGAPYHMTGGGLTILSNRVNYVFNLKGPSMTIDTACSSTMYALHLACRSLQAGDCSAAIVAGTNLIFGIEQQIGSVRLGVLSPTSACHTFDESADGYARAEAVGSLYLKTLSQAIADGDPIRAIVRGTSINANGKSPGISHPSAQDQEMVIRKAYASAGLDLDQTGYFECHGTGTPVGDPLEVSAIGNVFGNVRTAENPLLMGSVKTNLGHGEAASAISSLIKTILCLEKGEIPATIGIKRLNPDLNLRDGRLKIVQTRSPWPAAQHYLRASVNSFGYGGANAHAILDAVQSYLGDVYQSIPASLPAPEKSASKKYLLLPFSAHSEPTLERNIETISHSFKSGSFSLPDLAHTLGSRRSNHSVRAFGLVSGDADGPQLVDSLRPSKLTVGTAAGASPKLAFIFTGQGAQWAQMGYELVQEYAVVRQTLQDLGRTISKLPNAPDWDLLEALAQPKTKSRVNEAELSQPLTTAVQIAMVDLLRSWGVHPTAVAGHSSGEIAAAYTAGLISAAEAIIIAYQRGAATVKSTQQGAMLAVGQGPEEVLQVIQDIPGVGIACYNAPDSVTLSGTEKAIDEARGRFARAGVFNRKLITSGNAYHSELMTEAGTYYETFLKTCLLPNDPPSTGHASVTMFSSVTEEELSTIELDYWRKNLESPVRFDQATQKLLKQRPEVNVVVEIGPHSALAAPLKAIRTSVGYSPERLVYLSALKRNADSVESMLKLAGSLFLSGWPLDLSTVNADETVYQDETGAERIQYSHGSFIKDLPTYQWTYDEDFLWNESRLSTDIRFRSYPHHDLLGSRLPGTSNAAPAWRNLLSLDQVPWLRDHKVGEDIVFPAAGYVALAVEAVTQIRGSTVTTVDDAYTLRDVNITSAMVLKEGLSTELMFDLFAVTGQPATYQFSVTTVSQGTWTQHATGSVLIDSKNTNDQLLWPDDRNVGSRGGVNKDSYDRRWYAAMDKVGLIYGPGFKTLADIRASPEHLQATAEVSRTATDGLMGHQSEYMLHPTTIDACLQLSIIAAHHGKPESLNKVYLPVAIRKLTIRPQKDSGGVIPLAACGRGHHRGLRSVQTFIDLSSPSNRSLLQAEISFSSLETASSDTVTSKSPQPYTRLVWKPDFDRMSNAEANALFHGTQEDMSASRHFFSELEKVTRLAIRSSAERLPENLQTDHLPAHMHKFLAWLKTEGQALASSEGHDGLTGKDLMEEINSIARNVAHTVPEAAMVAQLNSRMPEIVSGTVGALDVMVEDDLMSKIYEDGFGQVGAYAKLSSVMELVAHKDPSLRILELGAGTGGATKPMLQALQGDTPLPKYAKYDFTDVSKAFLGVAQDKFEGYRNLDFGILDIEQDPAAQGFEEGSYDIVFASNVIHATRNVASSLSHCRRLLKPNGKLMIIETTKQRQVTGFMLGTLPGYWLGADDGRPSSPFLSKALWHQRLLDAGLSGADVVLDDYPEPADCTTLMVSRNVGDAVEHTSMNGTHGVNGVNGFHETNGQNGLNGANGVKSPLVTLIYRNTPQPFQQALEQKYAQLGISTRSMALLDVPTSLERDSRTVMLGELESPLMARMTPDEMHAIQRYTQLAATAIWVTNIDVLQGRDAEKSLVFGLAKSIMTEQPSFHLCSVDVDIYDGKTDYEHSSKLIVETEMAFHDDPNGDLDTELVEKDGLVYISRYVTDDAENANFERHLAIKPTMSSFSESDSSNYSLEFEKVGRLDSFYFKEHSLKALGEHEVLLDIEAAPLDELSIPTLKGQASSSCFGLVMAGTVRAVGPKASKLKKGDRVCCLHPHHFDTAVIVDERVCELLSAHERSEDLISQIHPVVVSLHIVETLLRLRTGDRVLIDCRQAYLAYAIAQVALLAGSTVQVTFNSEPGRGFLQNLGDNAHLVDRRAGFNDSLVGSSFDAIITDAKEGYQLFCESLTYGGRITVLANGAPGDMASAAVSFLNKGTTVGMFDPIDGFANVPLQHSSLVTKALDLLRHNTIRPLPSTQYDLSSFTDAVGHISQEDSVGLAVLTRTSNTAVPIHTVTQPLEFNSQASYLLIGCLGGLGRSLTTWMVSRGARHFVFLSRSGADKPEAAALVQELGELTRTRYYDLTVQVVRGDVSSKEDVSRAIACAKQPIKGVVQAAMVLKDTLFTEMTLGQFNQVLHPKMLGTIHLHELLQDHDLDFFVMTSSVLGAIGAAMQSNYSAANAFLDHMARYRQSQGQQATSIALGMILDVGHVEEHPEVEKALKRNGMYGISVDEYLLMMEFACRRRDLSASARKEGPFKYDPCASAHIVTGMDPTRVSRAGGKSLWLKDNRLRNLVAALGGGSEGEDALNAKQSAGTSTRELLDAARAEGGEAAVKSAILGLILARFSKLVLLPVAKIDPGKSLAHYGMDSMISAELKSWAWREFTVDLPFLGLLDQGLTFDGLADQVVSLAETRSS", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Ketoacyl_synth_C, PKS_ER, PKS_PP-bd, PKS_DH_C, PKS_assoc, Acyl_transferase_dom, PP-bd_ACP, PKS_DH, PKS_Beta-ketoAc_synthase_dom, PKS_Beta-ketoAc_synthase_dom, Ketoacyl_synth_N, Acyl_transferase_dom, PKS_mFAS_DH, Methyltransf_12, PKS_KR, PKS_DH_N that are essential for its biological function; 2. The protein should belong to PKS_NRPS_Biosynth_Enz that shares evolutionary origin and functional similarity; 3. The protein should be classified within SAM-dependent_MTases_sf, PKS_dehydratase_sf, GroES-like_sf, ACP-like_sf, NAD(P)-bd_dom_sf, Ac_transferase_dom_sf, Thiolase-like, Acyl_Trfase/lysoPLipase, SAM-dependent_MTases_sf, NAD(P)-bd_dom_sf, Malonyl_transacylase_ACP-bd, Thiolase-like sharing conserved structural features; 4. The protein must have Ketoacyl_synth_AS that is conserved among related catalytic enzymes. The designed protein sequence is ", "reference": "MAPQNNGYPEPIAIVGMACRLPGEVTSPSKLWDLLVEERSAQSDVPSNRFNVDSWYHPDKTRPGSISTRGGYFLSEDDSYRQFDPFFFGINPKEAASMDPQQRKLLEVVYESFEAAGARLEDVSGSKTACYVGNFTWDIGQMQARDVNHGAPYHMTGGGLTILSNRVNYVFNLKGPSMTIDTACSSTMYALHLACRSLQAGDCSAAIVAGTNLIFGIEQQIGSVRLGVLSPTSACHTFDESADGYARAEAVGSLYLKTLSQAIADGDPIRAIVRGTSINANGKSPGISHPSAQDQEMVIRKAYASAGLDLDQTGYFECHGTGTPVGDPLEVSAIGNVFGNVRTAENPLLMGSVKTNLGHGEAASAISSLIKTILCLEKGEIPATIGIKRLNPDLNLRDGRLKIVQTRSPWPAAQHYLRASVNSFGYGGANAHAILDAVQSYLGDVYQSIPASLPAPEKSASKKYLLLPFSAHSEPTLERNIETISHSFKSGSFSLPDLAHTLGSRRSNHSVRAFGLVSGDADGPQLVDSLRPSKLTVGTAAGASPKLAFIFTGQGAQWAQMGYELVQEYAVVRQTLQDLGRTISKLPNAPDWDLLEALAQPKTKSRVNEAELSQPLTTAVQIAMVDLLRSWGVHPTAVAGHSSGEIAAAYTAGLISAAEAIIIAYQRGAATVKSTQQGAMLAVGQGPEEVLQVIQDIPGVGIACYNAPDSVTLSGTEKAIDEARGRFARAGVFNRKLITSGNAYHSELMTEAGTYYETFLKTCLLPNDPPSTGHASVTMFSSVTEEELSTIELDYWRKNLESPVRFDQATQKLLKQRPEVNVVVEIGPHSALAAPLKAIRTSVGYSPERLVYLSALKRNADSVESMLKLAGSLFLSGWPLDLSTVNADETVYQDETGAERIQYSHGSFIKDLPTYQWTYDEDFLWNESRLSTDIRFRSYPHHDLLGSRLPGTSNAAPAWRNLLSLDQVPWLRDHKVGEDIVFPAAGYVALAVEAVTQIRGSTVTTVDDAYTLRDVNITSAMVLKEGLSTELMFDLFAVTGQPATYQFSVTTVSQGTWTQHATGSVLIDSKNTNDQLLWPDDRNVGSRGGVNKDSYDRRWYAAMDKVGLIYGPGFKTLADIRASPEHLQATAEVSRTATDGLMGHQSEYMLHPTTIDACLQLSIIAAHHGKPESLNKVYLPVAIRKLTIRPQKDSGGVIPLAACGRGHHRGLRSVQTFIDLSSPSNRSLLQAEISFSSLETASSDTVTSKSPQPYTRLVWKPDFDRMSNAEANALFHGTQEDMSASRHFFSELEKVTRLAIRSSAERLPENLQTDHLPAHMHKFLAWLKTEGQALASSEGHDGLTGKDLMEEINSIARNVAHTVPEAAMVAQLNSRMPEIVSGTVGALDVMVEDDLMSKIYEDGFGQVGAYAKLSSVMELVAHKDPSLRILELGAGTGGATKPMLQALQGDTPLPKYAKYDFTDVSKAFLGVAQDKFEGYRNLDFGILDIEQDPAAQGFEEGSYDIVFASNVIHATRNVASSLSHCRRLLKPNGKLMIIETTKQRQVTGFMLGTLPGYWLGADDGRPSSPFLSKALWHQRLLDAGLSGADVVLDDYPEPADCTTLMVSRNVGDAVEHTSMNGTHGVNGVNGFHETNGQNGLNGANGVKSPLVTLIYRNTPQPFQQALEQKYAQLGISTRSMALLDVPTSLERDSRTVMLGELESPLMARMTPDEMHAIQRYTQLAATAIWVTNIDVLQGRDAEKSLVFGLAKSIMTEQPSFHLCSVDVDIYDGKTDYEHSSKLIVETEMAFHDDPNGDLDTELVEKDGLVYISRYVTDDAENANFERHLAIKPTMSSFSESDSSNYSLEFEKVGRLDSFYFKEHSLKALGEHEVLLDIEAAPLDELSIPTLKGQASSSCFGLVMAGTVRAVGPKASKLKKGDRVCCLHPHHFDTAVIVDERVCELLSAHERSEDLISQIHPVVVSLHIVETLLRLRTGDRVLIDCRQAYLAYAIAQVALLAGSTVQVTFNSEPGRGFLQNLGDNAHLVDRRAGFNDSLVGSSFDAIITDAKEGYQLFCESLTYGGRITVLANGAPGDMASAAVSFLNKGTTVGMFDPIDGFANVPLQHSSLVTKALDLLRHNTIRPLPSTQYDLSSFTDAVGHISQEDSVGLAVLTRTSNTAVPIHTVTQPLEFNSQASYLLIGCLGGLGRSLTTWMVSRGARHFVFLSRSGADKPEAAALVQELGELTRTRYYDLTVQVVRGDVSSKEDVSRAIACAKQPIKGVVQAAMVLKDTLFTEMTLGQFNQVLHPKMLGTIHLHELLQDHDLDFFVMTSSVLGAIGAAMQSNYSAANAFLDHMARYRQSQGQQATSIALGMILDVGHVEEHPEVEKALKRNGMYGISVDEYLLMMEFACRRRDLSASARKEGPFKYDPCASAHIVTGMDPTRVSRAGGKSLWLKDNRLRNLVAALGGGSEGEDALNAKQSAGTSTRELLDAARAEGGEAAVKSAILGLILARFSKLVLLPVAKIDPGKSLAHYGMDSMISAELKSWAWREFTVDLPFLGLLDQGLTFDGLADQVVSLAETRSS" }, { "InterPro": [ { "InterPro-ID": "IPR018201", "InterPro-Name": "Ketoacyl_synth_AS", "InterPro-Type": "ACTIVE_SITE", "Beg": 173, "End": 189 }, { "InterPro-ID": "IPR020843", "InterPro-Name": "PKS_ER", "InterPro-Type": "DOMAIN", "Beg": 1866, "End": 2186 }, { "InterPro-ID": "IPR016036", "InterPro-Name": "Malonyl_transacylase_ACP-bd", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 673, "End": 735 }, { "InterPro-ID": "IPR029063", "InterPro-Name": "SAM-dependent_MTases_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1392, "End": 1579 }, { "InterPro-ID": "IPR011032", "InterPro-Name": "GroES-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1858, "End": 1955 }, { "InterPro-ID": "IPR042104", "InterPro-Name": "PKS_dehydratase_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 911, "End": 1220 }, { "InterPro-ID": "IPR049900", "InterPro-Name": "PKS_mFAS_DH", "InterPro-Type": "DOMAIN", "Beg": 927, "End": 1227 }, { "InterPro-ID": "IPR014031", "InterPro-Name": "Ketoacyl_synth_C", "InterPro-Type": "DOMAIN", "Beg": 269, "End": 385 }, { "InterPro-ID": "IPR016039", "InterPro-Name": "Thiolase-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 4, "End": 381 }, { "InterPro-ID": "IPR029063", "InterPro-Name": "SAM-dependent_MTases_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1257, "End": 1574 }, { "InterPro-ID": "IPR032821", "InterPro-Name": "PKS_assoc", "InterPro-Type": "DOMAIN", "Beg": 389, "End": 512 }, { "InterPro-ID": "IPR020807", "InterPro-Name": "PKS_DH", "InterPro-Type": "DOMAIN", "Beg": 927, "End": 1098 }, { "InterPro-ID": "IPR013217", "InterPro-Name": "Methyltransf_12", "InterPro-Type": "DOMAIN", "Beg": 1409, "End": 1514 }, { "InterPro-ID": "IPR014043", "InterPro-Name": "Acyl_transferase_dom", "InterPro-Type": "DOMAIN", "Beg": 546, "End": 855 }, { "InterPro-ID": "IPR020841", "InterPro-Name": "PKS_Beta-ketoAc_synthase_dom", "InterPro-Type": "DOMAIN", "Beg": 7, "End": 435 }, { "InterPro-ID": "IPR013968", "InterPro-Name": "PKS_KR", "InterPro-Type": "DOMAIN", "Beg": 2209, "End": 2389 }, { "InterPro-ID": "IPR049552", "InterPro-Name": "PKS_DH_N", "InterPro-Type": "DOMAIN", "Beg": 927, "End": 1020 }, { "InterPro-ID": "IPR016035", "InterPro-Name": "Acyl_Trfase/lysoPLipase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 543, "End": 836 }, { "InterPro-ID": "IPR020841", "InterPro-Name": "PKS_Beta-ketoAc_synthase_dom", "InterPro-Type": "DOMAIN", "Beg": 10, "End": 438 }, { "InterPro-ID": "IPR016039", "InterPro-Name": "Thiolase-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 6, "End": 519 }, { "InterPro-ID": "IPR049551", "InterPro-Name": "PKS_DH_C", "InterPro-Type": "DOMAIN", "Beg": 1077, "End": 1212 }, { "InterPro-ID": "IPR014030", "InterPro-Name": "Ketoacyl_synth_N", "InterPro-Type": "DOMAIN", "Beg": 8, "End": 260 }, { "InterPro-ID": "IPR001227", "InterPro-Name": "Ac_transferase_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 542, "End": 843 }, { "InterPro-ID": "IPR014043", "InterPro-Name": "Acyl_transferase_dom", "InterPro-Type": "DOMAIN", "Beg": 545, "End": 872 }, { "InterPro-ID": "IPR036291", "InterPro-Name": "NAD(P)-bd_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 2210, "End": 2418 }, { "InterPro-ID": "IPR050091", "InterPro-Name": "PKS_NRPS_Biosynth_Enz", "InterPro-Type": "FAMILY", "Beg": 9, "End": 2525 } ], "response#1": "MKPYHHPEPIAIVGMACRLPGDIESPSKLWDLLAQERSAQSDVPHNRFNVDSWYHPNKQRPGSIHTRGGYFLSQDDSFRQFDASFFGINPKEAASMDPQQRKLLEVVYESFEAAGARLEDVSGSNTACYVGNFTWDIGQMQARDINHGAPYHMTGGGLTILSNRVNYVFNLKGPSMTIDTACSSTMYALHMACRSLQAGDCSAAVVAGTNLIFGIEQQIASVRLGVLSPTSTCHTFDESADGYARAEAIGALYLKPLSQAMADKDPIRAVIRGTSINANGRSSGISHPSSTDQELVIRQAYASAQLGFEQTGYFECHGTGTPVGDPLEVTAIGNVFGDVRTPESPLLMGSVKTNLGHGEAASAISSLIKTVLCLEKGQIPATLGIKRLNPALDLRDGRLKVVQTLSPWPAAQSYLRASVNSFGYGGANAHAILDAVQSYLGDLYQSIPAPMELKTHSPKQCYLLPFSAHDEQTLNRNIRALSQSLQSGVHLPSLAYTLDSRRSNHSERAFALISTKSDGIQLSEKLSPDSLTFGTAMGSRPELAFVFTGQGAQWAQMGQELVEQYEVVRKTLQNLGATIAGLQNAPDWNLLEALAQPQEKSRINEAELSQPLTTAIQIAMVDLLRSWGVTPVAVVGHSSGEIAAAYCAGHITAKEAIVIAYQRGAATVKSTQRGAMLAVGLGPAEALQVIEDIPNIGIACYNSPDSVTLSGSEKAIEEARKRFLIESIFHRKLKTSGNAYHSNLMEEAGQHYERFLQQSLSRELQSTTESEITMFSSVTETPVETVDLAYWRQNLESAVRFDTATQQLLKSRPEVKIIIEIGPHSALAAPIKAIRTVVGYNSEQLVYLPSLKRNTNSVECLLNLVGSLFLSGFPAPISTVNSASNIGQSPQYFIPDLPIYQWKYGQDIMWAESRMSTDIRFRAYPHHDLLGSRIPGTSNSAPAWRNLISIDSVPWLQDHKVGDSVVFPAAGYVALALEAITQTQGSLTGAYTLRDVNINSAMLLKEGSDTELIFDLHVVVSQQGAYKFVASTVSNGTWTEHATGFVRVGEDYTTNETLRINSTIVGGRGGINKDSYVRRWYSAMNKVGLGYGEAFKTLSNIRANAEYSHATAEVPYNASEGQMAQQSRYAVHPTTLDACLQLSIIAAHNGKPEDLIKAYLPVSISKLTVWPSKIRQDVSLEAFGRGFHRGLRSIQASTGLSTPDGQSLLQAELSFLSLETATKEVDAAKMPQPYTRLIWKPDVDRLTNAQAKALFSQTQADESTAKSYFSSLETLTQLAIRSVVERLPHDLQADSLPGHMQKFFKWLLQENAAISNGALDGLTGEKLIEKIYSIAQSLEQRVPEAAMVAQLNTKMPQIVSGTIGALDVMVENDLLTRIYEDGFGQIGAYARLADFMALMAHKNPRLRILELGAGTGGATRVMLNALEGETSLPKYENYAFTDVSKAFLGVAQETFQAHRHLEFGILDIEHDPASQSFEEHSYDIVFASNVIHATRSVASSLRNCKRLLKPNGKLIIVETTKDWQFTGFMLGALPGYWLGADDGRPYSPFLSKAMWNQVLLDAGFAGADIMLDDYDEPASCTTLIVACNTGEDVRLNENGAKGTNGVNGTNGINSTNSVNVTNDTSGINDTNRMNDNNDMKGMNGGNEGHNTIDTERLNGVKPSTVTLIYRYEPQPIQRAIEREYAQMGITTRSMALEAVTTSLERDARTIMLAELESPLLARMTAAEMTAVQRYTQLATTALWVTNGGVMQGQDPEKSLIFGLAKAIMTEQPSFHLCSLDIDIDNMDLENSNSVSLVMDVERAFHQDPHAEMDTELVEKDGLVYISRYVSDFTENTSFERHLAFKPTMSSVPQGNDALALRFEKVGKANSFYFESQGLRPLTGDEVLIDVDATPLDPLSIDALMGKSSSLSFGMILAGTVRAVGFKTRKLEVGDYVCCLYPHHFDTAVIMHERDCEIIVSEERTGNLLGQIYPSIISLHVASSLRLDRGDHVLIDCQQVHLAYTFAQVALLRAIGVDVTFYSDAGLDKLKHLLGDKAKLISREEALKQASSANFFDAVLTDANDGFQLLVNVARPGGRILALGSSPPTDMIHAAPYFLKKGVTMGMFDPMDGFATNLTQQSKVTSNDGNHDASPELTQSRSLLAEALGLLHHGSIRPLPCERFDLARLPEAISKVAQGDSVGSVVLTRTPDTRVPVHAAEDLLMFNPEASYLLVGCLGGLGRSLTAWMVSRGARHFIFLSRSGADKPEAAALVDELHELARSKYPDLSVQVIRGDVSARDDVKRAISCATKPIKGVVQAAMVLKDKLFSEMSLDDFNKVVHPKMLGSLHLHELLLNHDLDFFVMTSSVLGAIGAAMQSNYSAANAYLDHMARHRRSMGLQAMSMALGMIVDVGHVEEHPEVEKALKRNGLYGISVDEYLINMELACRRQDLSNPIPPQSPYRYDAGAAAHIVTGMDPTRLSRAGGKSLWLKDNRLRNIVVGLGDASGEDERNAENATGVNTAKLLESARAEGGTTAVKSVVLGLVLARFSKLVLLPVEKIDP", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more PKS_ER, PKS_mFAS_DH, Ketoacyl_synth_C, PKS_assoc, PKS_DH, Methyltransf_12, Acyl_transferase_dom, PKS_Beta-ketoAc_synthase_dom, PKS_KR, PKS_DH_N, PKS_Beta-ketoAc_synthase_dom, PKS_DH_C, Ketoacyl_synth_N, Acyl_transferase_dom that are essential for its biological function; 2. The protein should belong to PKS_NRPS_Biosynth_Enz that shares evolutionary origin and functional similarity; 3. The protein should be classified within Malonyl_transacylase_ACP-bd, SAM-dependent_MTases_sf, GroES-like_sf, PKS_dehydratase_sf, Thiolase-like, SAM-dependent_MTases_sf, Acyl_Trfase/lysoPLipase, Thiolase-like, Ac_transferase_dom_sf, NAD(P)-bd_dom_sf sharing conserved structural features; 4. The protein must have Ketoacyl_synth_AS that is conserved among related catalytic enzymes. The designed protein sequence is ", "reference": "MKPYHHPEPIAIVGMACRLPGDIESPSKLWDLLAQERSAQSDVPHNRFNVDSWYHPNKQRPGSIHTRGGYFLSQDDSFRQFDASFFGINPKEAASMDPQQRKLLEVVYESFEAAGARLEDVSGSNTACYVGNFTWDIGQMQARDINHGAPYHMTGGGLTILSNRVNYVFNLKGPSMTIDTACSSTMYALHMACRSLQAGDCSAAVVAGTNLIFGIEQQIASVRLGVLSPTSTCHTFDESADGYARAEAIGALYLKPLSQAMADKDPIRAVIRGTSINANGRSSGISHPSSTDQELVIRQAYASAQLGFEQTGYFECHGTGTPVGDPLEVTAIGNVFGDVRTPESPLLMGSVKTNLGHGEAASAISSLIKTVLCLEKGQIPATLGIKRLNPALDLRDGRLKVVQTLSPWPAAQSYLRASVNSFGYGGANAHAILDAVQSYLGDLYQSIPAPMELKTHSPKQCYLLPFSAHDEQTLNRNIRALSQSLQSGVHLPSLAYTLDSRRSNHSERAFALISTKSDGIQLSEKLSPDSLTFGTAMGSRPELAFVFTGQGAQWAQMGQELVEQYEVVRKTLQNLGATIAGLQNAPDWNLLEALAQPQEKSRINEAELSQPLTTAIQIAMVDLLRSWGVTPVAVVGHSSGEIAAAYCAGHITAKEAIVIAYQRGAATVKSTQRGAMLAVGLGPAEALQVIEDIPNIGIACYNSPDSVTLSGSEKAIEEARKRFLIESIFHRKLKTSGNAYHSNLMEEAGQHYERFLQQSLSRELQSTTESEITMFSSVTETPVETVDLAYWRQNLESAVRFDTATQQLLKSRPEVKIIIEIGPHSALAAPIKAIRTVVGYNSEQLVYLPSLKRNTNSVECLLNLVGSLFLSGFPAPISTVNSASNIGQSPQYFIPDLPIYQWKYGQDIMWAESRMSTDIRFRAYPHHDLLGSRIPGTSNSAPAWRNLISIDSVPWLQDHKVGDSVVFPAAGYVALALEAITQTQGSLTGAYTLRDVNINSAMLLKEGSDTELIFDLHVVVSQQGAYKFVASTVSNGTWTEHATGFVRVGEDYTTNETLRINSTIVGGRGGINKDSYVRRWYSAMNKVGLGYGEAFKTLSNIRANAEYSHATAEVPYNASEGQMAQQSRYAVHPTTLDACLQLSIIAAHNGKPEDLIKAYLPVSISKLTVWPSKIRQDVSLEAFGRGFHRGLRSIQASTGLSTPDGQSLLQAELSFLSLETATKEVDAAKMPQPYTRLIWKPDVDRLTNAQAKALFSQTQADESTAKSYFSSLETLTQLAIRSVVERLPHDLQADSLPGHMQKFFKWLLQENAAISNGALDGLTGEKLIEKIYSIAQSLEQRVPEAAMVAQLNTKMPQIVSGTIGALDVMVENDLLTRIYEDGFGQIGAYARLADFMALMAHKNPRLRILELGAGTGGATRVMLNALEGETSLPKYENYAFTDVSKAFLGVAQETFQAHRHLEFGILDIEHDPASQSFEEHSYDIVFASNVIHATRSVASSLRNCKRLLKPNGKLIIVETTKDWQFTGFMLGALPGYWLGADDGRPYSPFLSKAMWNQVLLDAGFAGADIMLDDYDEPASCTTLIVACNTGEDVRLNENGAKGTNGVNGTNGINSTNSVNVTNDTSGINDTNRMNDNNDMKGMNGGNEGHNTIDTERLNGVKPSTVTLIYRYEPQPIQRAIEREYAQMGITTRSMALEAVTTSLERDARTIMLAELESPLLARMTAAEMTAVQRYTQLATTALWVTNGGVMQGQDPEKSLIFGLAKAIMTEQPSFHLCSLDIDIDNMDLENSNSVSLVMDVERAFHQDPHAEMDTELVEKDGLVYISRYVSDFTENTSFERHLAFKPTMSSVPQGNDALALRFEKVGKANSFYFESQGLRPLTGDEVLIDVDATPLDPLSIDALMGKSSSLSFGMILAGTVRAVGFKTRKLEVGDYVCCLYPHHFDTAVIMHERDCEIIVSEERTGNLLGQIYPSIISLHVASSLRLDRGDHVLIDCQQVHLAYTFAQVALLRAIGVDVTFYSDAGLDKLKHLLGDKAKLISREEALKQASSANFFDAVLTDANDGFQLLVNVARPGGRILALGSSPPTDMIHAAPYFLKKGVTMGMFDPMDGFATNLTQQSKVTSNDGNHDASPELTQSRSLLAEALGLLHHGSIRPLPCERFDLARLPEAISKVAQGDSVGSVVLTRTPDTRVPVHAAEDLLMFNPEASYLLVGCLGGLGRSLTAWMVSRGARHFIFLSRSGADKPEAAALVDELHELARSKYPDLSVQVIRGDVSARDDVKRAISCATKPIKGVVQAAMVLKDKLFSEMSLDDFNKVVHPKMLGSLHLHELLLNHDLDFFVMTSSVLGAIGAAMQSNYSAANAYLDHMARHRRSMGLQAMSMALGMIVDVGHVEEHPEVEKALKRNGLYGISVDEYLINMELACRRQDLSNPIPPQSPYRYDAGAAAHIVTGMDPTRLSRAGGKSLWLKDNRLRNIVVGLGDASGEDERNAENATGVNTAKLLESARAEGGTTAVKSVVLGLVLARFSKLVLLPVEKIDP" }, { "InterPro": [ { "InterPro-ID": "IPR036291", "InterPro-Name": "NAD(P)-bd_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1899, "End": 2067 }, { "InterPro-ID": "IPR049551", "InterPro-Name": "PKS_DH_C", "InterPro-Type": "DOMAIN", "Beg": 1066, "End": 1163 }, { "InterPro-ID": "IPR050091", "InterPro-Name": "PKS_NRPS_Biosynth_Enz", "InterPro-Type": "FAMILY", "Beg": 10, "End": 2497 }, { "InterPro-ID": "IPR042104", "InterPro-Name": "PKS_dehydratase_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 926, "End": 1187 }, { "InterPro-ID": "IPR020806", "InterPro-Name": "PKS_PP-bd", "InterPro-Type": "DOMAIN", "Beg": 2429, "End": 2484 }, { "InterPro-ID": "IPR036291", "InterPro-Name": "NAD(P)-bd_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 2117, "End": 2336 }, { "InterPro-ID": "IPR011032", "InterPro-Name": "GroES-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1820, "End": 1902 }, { "InterPro-ID": "IPR014031", "InterPro-Name": "Ketoacyl_synth_C", "InterPro-Type": "DOMAIN", "Beg": 270, "End": 386 }, { "InterPro-ID": "IPR016036", "InterPro-Name": "Malonyl_transacylase_ACP-bd", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 675, "End": 735 }, { "InterPro-ID": "IPR009081", "InterPro-Name": "PP-bd_ACP", "InterPro-Type": "DOMAIN", "Beg": 2423, "End": 2501 }, { "InterPro-ID": "IPR016039", "InterPro-Name": "Thiolase-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 8, "End": 434 }, { "InterPro-ID": "IPR049900", "InterPro-Name": "PKS_mFAS_DH", "InterPro-Type": "DOMAIN", "Beg": 941, "End": 1212 }, { "InterPro-ID": "IPR013217", "InterPro-Name": "Methyltransf_12", "InterPro-Type": "DOMAIN", "Beg": 1398, "End": 1503 }, { "InterPro-ID": "IPR014043", "InterPro-Name": "Acyl_transferase_dom", "InterPro-Type": "DOMAIN", "Beg": 548, "End": 858 }, { "InterPro-ID": "IPR036736", "InterPro-Name": "ACP-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 2431, "End": 2497 }, { "InterPro-ID": "IPR020841", "InterPro-Name": "PKS_Beta-ketoAc_synthase_dom", "InterPro-Type": "DOMAIN", "Beg": 11, "End": 439 }, { "InterPro-ID": "IPR020841", "InterPro-Name": "PKS_Beta-ketoAc_synthase_dom", "InterPro-Type": "DOMAIN", "Beg": 8, "End": 436 }, { "InterPro-ID": "IPR020807", "InterPro-Name": "PKS_DH", "InterPro-Type": "DOMAIN", "Beg": 941, "End": 1086 }, { "InterPro-ID": "IPR014043", "InterPro-Name": "Acyl_transferase_dom", "InterPro-Type": "DOMAIN", "Beg": 547, "End": 875 }, { "InterPro-ID": "IPR018201", "InterPro-Name": "Ketoacyl_synth_AS", "InterPro-Type": "ACTIVE_SITE", "Beg": 174, "End": 190 }, { "InterPro-ID": "IPR029063", "InterPro-Name": "SAM-dependent_MTases_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1263, "End": 1563 }, { "InterPro-ID": "IPR016039", "InterPro-Name": "Thiolase-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 8, "End": 521 }, { "InterPro-ID": "IPR032821", "InterPro-Name": "PKS_assoc", "InterPro-Type": "DOMAIN", "Beg": 390, "End": 513 }, { "InterPro-ID": "IPR001227", "InterPro-Name": "Ac_transferase_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 544, "End": 844 }, { "InterPro-ID": "IPR013968", "InterPro-Name": "PKS_KR", "InterPro-Type": "DOMAIN", "Beg": 2116, "End": 2296 }, { "InterPro-ID": "IPR014030", "InterPro-Name": "Ketoacyl_synth_N", "InterPro-Type": "DOMAIN", "Beg": 9, "End": 261 }, { "InterPro-ID": "IPR036736", "InterPro-Name": "ACP-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 2432, "End": 2505 }, { "InterPro-ID": "IPR020843", "InterPro-Name": "PKS_ER", "InterPro-Type": "DOMAIN", "Beg": 1827, "End": 2093 }, { "InterPro-ID": "IPR016035", "InterPro-Name": "Acyl_Trfase/lysoPLipase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 544, "End": 843 }, { "InterPro-ID": "IPR029063", "InterPro-Name": "SAM-dependent_MTases_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1390, "End": 1569 }, { "InterPro-ID": "IPR049552", "InterPro-Name": "PKS_DH_N", "InterPro-Type": "DOMAIN", "Beg": 941, "End": 1005 } ], "response#1": "MQPHNPYVEPIAIVGMACRLPGDVVSPSKLWDLLVQERSAQSKVPANRFNVDSWYHPDKQRPGSITTRGGYFLSQDDSFRQFDPSFFGINPKEAASMDPQQRKLLEVVYESFEAAGARLEDVSGSKTACYVGNFTWDIGQMQARDINHGAPYHMTGGGLTILSNRINYVFNLKGPSMTIDTACSSTMYALHLACRSLQAGDCSAAVVAGTNLIFGIEQQIGSVRLGVLSPTSVCHTFDESADGYARAEAVGSLYLKTLSQAIADGDPIRAVIRGTAINANGRSPGISHPSAQEQEMVIRQAYARAGLRLDQTGYFECHGTGTPVGDPLEVSAIGNVFGPVRSAESPLLIGSVKTNLGHGEAASAISSLIKTALCLEKGEIPATIGIKRLNPALNLRDGRLKIVQTLSPWPDSQQYRRASVNSFGYGGANAHAILDAVQSYLGEFCQSIPASLTTPGQPSLKRYFLLPFSAHSESTLRQNIKSISHSFKCDVNLPDLAYTLASCRSNHSERAFALVAGDSSCSKLVDSLASDKLTFGTAMGAVPKLAFIFTGQGAQWPQMGHELVQHYAVVRQTLRDLGNVIAKLPNPPEWDLLDALDQPKSKSRVNEAELSQPLTTAIQIAIVNLLRSWGVHPTAVVGHSSGEIAAAYSAGLISAAEAIIIAYQRGAATVKSTQRGAMLAVGIGSDEALQAIHDIPDIGIACYNAPDSVTLSGTEEAVDMARGRFSRAGVFNRKLITSGNAYHSKLMAEAGQFYEASLKQCLLPNDPPSTGNADITMFSSVTEEPVSTLALEYWRQNLESPVHFDQATQKLLKARPEVNLVVEIGPHSALAAPLKAIRAAVGYSPERLVYLSALKRNSDSVECLLKMVGSLFLSGLPFALSTVNADATVHRDDKTGSEMIQYSHGSFIRDLPTYQWVYDEEPLWNESRLSTDIRFRSYPHHDLLGSRLPGTSNIAPAWRNMISLESVPWLRDHRVGDDIVFPAAGYVTLAIEAITQIRRSTISAVTDAYTLPAYEFAVSTFVNGTWTQHATGSVQVDNDSASDQSISSVENMAGSRGGINKDSYDRRWYGAMDKVGLIYGPGFKTLSDIRASPEHHWATAEVSGNATDKLMGRQSQYILHPTTIDACLQLSIIAAHHGKPESLKKVYLPVLIPKLTIWPHHSSQGLPLTACGRGLHRGLRSVQTFTGLSNPNHQTILQAEISFSSLETAVGENGTGKSPQPYTRLVWKPDLDRMTNTQAQILFHGTQDDISTSKHFFSRLEEVTRLAIRSSAERLPENLQADRLPGHMQKFLEWLKMEGLALSTNEAADGLTGESLLDKIDAIARSVEQTVPEAAMVAQLNSRMPEILAGTVGALDVMVEDNLMSRIYEEGFGQTGAYAKLSDVIDLVAHKDPRLRILELGAGTGGATKPMLKALHGDTPLPKYEKYDFTDVSKAFLGVAQDKFQGYRNLDFGILDIEKDPVAQGFPEQSYDIVFASNVIHATRNVASSLRNCKRLLKPDGKLLIIETTKQRQVTGFMLGALPGYWLGADDGRPSSPFLSKTLWHQRLLDAGLSGADIVLDDYPEPADCTTLIMSRNSSEAANHASMNGANHTNGANSINNISEINGVTGVNQLNGAKSLKPSTVTLIYRREPQPLQRALEAKYAQLGISTRSMALEDIPNSLERDSRTIMLAELEDPLMARMTPAEMHAVQRYTQQAATAIWVTNGNVLRGQDPEKSLVFGLAKSIMTEQPSFHLCSVDVDIGDGKADCGNSTTLLVETEMAFHHDPNGELDTELVEKDGLVYISRYVTDDTENANFERYFAIKPTVMALARGESSYYSLQFENVGRVDSFYFKEQSLKPLGENEVLLDVDAAPLDSLSIAALKGQIASPCFGLEIVGTVRAVGSKTSKLKEGNRIHPVVTSLHVVELLLGLHAGDQILVDCRQAHLACIISQVALLEGSRVYVTFDSEAGRDILQQLGNDSHLVDRQANFKQALLGTSFDAIVTDSTDSYQLFDNIINSGGRIVALANTAPVEMVNAAVSFLNKSVTIGMFDPFNGFATAPVQHSSLLAKALKLLRRNVIRPIPSTQYDLSYLPEAVGHISQDDYVGRVVLTRTPNTAVPIHTVAEPLMFNSEASYLLIGCLGGLGRSLTTWMVSRGARHFIFLSRSGADKPEAAALVKELHELTRAQYLDLTVQVVRGDVSIRDDVSRAISCATKPIKGVVQAAMVLKDTLFTEMSLAQFNQVLHPKMLGTIHLHELLQGHDLDFFVMTSSVLGAIGAAMQSNYSAANAYLDHMARHRQSLGLQATSIALGMILNVGHVEEHPEVEKALKRNGMYGISVDEYLLMMEFACRRRDLSSTTNSHDPYKYDPCATAHIVTGMDPTRVSRAGGKSLWLKDNRLRNLVAALGGGNNGDGFNAEQSAGPSTHELLEAARAEGGVAAVKVTTLGLILARFSKLVLLPVHKIDPGKALAHYGMDSMISAELKSWAWKEFTVDLPFLGLLDQSLTFDDLAEKVVALAETKST", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more PKS_DH_C, PKS_PP-bd, Ketoacyl_synth_C, PP-bd_ACP, PKS_mFAS_DH, Methyltransf_12, Acyl_transferase_dom, PKS_Beta-ketoAc_synthase_dom, PKS_Beta-ketoAc_synthase_dom, PKS_DH, Acyl_transferase_dom, PKS_assoc, PKS_KR, Ketoacyl_synth_N, PKS_ER, PKS_DH_N that are essential for its biological function; 2. The protein should belong to PKS_NRPS_Biosynth_Enz that shares evolutionary origin and functional similarity; 3. The protein should be classified within NAD(P)-bd_dom_sf, PKS_dehydratase_sf, NAD(P)-bd_dom_sf, GroES-like_sf, Malonyl_transacylase_ACP-bd, Thiolase-like, ACP-like_sf, SAM-dependent_MTases_sf, Thiolase-like, Ac_transferase_dom_sf, ACP-like_sf, Acyl_Trfase/lysoPLipase, SAM-dependent_MTases_sf sharing conserved structural features; 4. The protein must have Ketoacyl_synth_AS that is conserved among related catalytic enzymes. The designed protein sequence is ", "reference": "MQPHNPYVEPIAIVGMACRLPGDVVSPSKLWDLLVQERSAQSKVPANRFNVDSWYHPDKQRPGSITTRGGYFLSQDDSFRQFDPSFFGINPKEAASMDPQQRKLLEVVYESFEAAGARLEDVSGSKTACYVGNFTWDIGQMQARDINHGAPYHMTGGGLTILSNRINYVFNLKGPSMTIDTACSSTMYALHLACRSLQAGDCSAAVVAGTNLIFGIEQQIGSVRLGVLSPTSVCHTFDESADGYARAEAVGSLYLKTLSQAIADGDPIRAVIRGTAINANGRSPGISHPSAQEQEMVIRQAYARAGLRLDQTGYFECHGTGTPVGDPLEVSAIGNVFGPVRSAESPLLIGSVKTNLGHGEAASAISSLIKTALCLEKGEIPATIGIKRLNPALNLRDGRLKIVQTLSPWPDSQQYRRASVNSFGYGGANAHAILDAVQSYLGEFCQSIPASLTTPGQPSLKRYFLLPFSAHSESTLRQNIKSISHSFKCDVNLPDLAYTLASCRSNHSERAFALVAGDSSCSKLVDSLASDKLTFGTAMGAVPKLAFIFTGQGAQWPQMGHELVQHYAVVRQTLRDLGNVIAKLPNPPEWDLLDALDQPKSKSRVNEAELSQPLTTAIQIAIVNLLRSWGVHPTAVVGHSSGEIAAAYSAGLISAAEAIIIAYQRGAATVKSTQRGAMLAVGIGSDEALQAIHDIPDIGIACYNAPDSVTLSGTEEAVDMARGRFSRAGVFNRKLITSGNAYHSKLMAEAGQFYEASLKQCLLPNDPPSTGNADITMFSSVTEEPVSTLALEYWRQNLESPVHFDQATQKLLKARPEVNLVVEIGPHSALAAPLKAIRAAVGYSPERLVYLSALKRNSDSVECLLKMVGSLFLSGLPFALSTVNADATVHRDDKTGSEMIQYSHGSFIRDLPTYQWVYDEEPLWNESRLSTDIRFRSYPHHDLLGSRLPGTSNIAPAWRNMISLESVPWLRDHRVGDDIVFPAAGYVTLAIEAITQIRRSTISAVTDAYTLPAYEFAVSTFVNGTWTQHATGSVQVDNDSASDQSISSVENMAGSRGGINKDSYDRRWYGAMDKVGLIYGPGFKTLSDIRASPEHHWATAEVSGNATDKLMGRQSQYILHPTTIDACLQLSIIAAHHGKPESLKKVYLPVLIPKLTIWPHHSSQGLPLTACGRGLHRGLRSVQTFTGLSNPNHQTILQAEISFSSLETAVGENGTGKSPQPYTRLVWKPDLDRMTNTQAQILFHGTQDDISTSKHFFSRLEEVTRLAIRSSAERLPENLQADRLPGHMQKFLEWLKMEGLALSTNEAADGLTGESLLDKIDAIARSVEQTVPEAAMVAQLNSRMPEILAGTVGALDVMVEDNLMSRIYEEGFGQTGAYAKLSDVIDLVAHKDPRLRILELGAGTGGATKPMLKALHGDTPLPKYEKYDFTDVSKAFLGVAQDKFQGYRNLDFGILDIEKDPVAQGFPEQSYDIVFASNVIHATRNVASSLRNCKRLLKPDGKLLIIETTKQRQVTGFMLGALPGYWLGADDGRPSSPFLSKTLWHQRLLDAGLSGADIVLDDYPEPADCTTLIMSRNSSEAANHASMNGANHTNGANSINNISEINGVTGVNQLNGAKSLKPSTVTLIYRREPQPLQRALEAKYAQLGISTRSMALEDIPNSLERDSRTIMLAELEDPLMARMTPAEMHAVQRYTQQAATAIWVTNGNVLRGQDPEKSLVFGLAKSIMTEQPSFHLCSVDVDIGDGKADCGNSTTLLVETEMAFHHDPNGELDTELVEKDGLVYISRYVTDDTENANFERYFAIKPTVMALARGESSYYSLQFENVGRVDSFYFKEQSLKPLGENEVLLDVDAAPLDSLSIAALKGQIASPCFGLEIVGTVRAVGSKTSKLKEGNRIHPVVTSLHVVELLLGLHAGDQILVDCRQAHLACIISQVALLEGSRVYVTFDSEAGRDILQQLGNDSHLVDRQANFKQALLGTSFDAIVTDSTDSYQLFDNIINSGGRIVALANTAPVEMVNAAVSFLNKSVTIGMFDPFNGFATAPVQHSSLLAKALKLLRRNVIRPIPSTQYDLSYLPEAVGHISQDDYVGRVVLTRTPNTAVPIHTVAEPLMFNSEASYLLIGCLGGLGRSLTTWMVSRGARHFIFLSRSGADKPEAAALVKELHELTRAQYLDLTVQVVRGDVSIRDDVSRAISCATKPIKGVVQAAMVLKDTLFTEMSLAQFNQVLHPKMLGTIHLHELLQGHDLDFFVMTSSVLGAIGAAMQSNYSAANAYLDHMARHRQSLGLQATSIALGMILNVGHVEEHPEVEKALKRNGMYGISVDEYLLMMEFACRRRDLSSTTNSHDPYKYDPCATAHIVTGMDPTRVSRAGGKSLWLKDNRLRNLVAALGGGNNGDGFNAEQSAGPSTHELLEAARAEGGVAAVKVTTLGLILARFSKLVLLPVHKIDPGKALAHYGMDSMISAELKSWAWKEFTVDLPFLGLLDQSLTFDDLAEKVVALAETKST" }, { "InterPro": [ { "InterPro-ID": "IPR029063", "InterPro-Name": "SAM-dependent_MTases_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 13, "End": 222 }, { "InterPro-ID": "IPR013216", "InterPro-Name": "Methyltransf_11", "InterPro-Type": "DOMAIN", "Beg": 67, "End": 165 }, { "InterPro-ID": "IPR050447", "InterPro-Name": "Erg6_SMT_methyltransf", "InterPro-Type": "FAMILY", "Beg": 8, "End": 218 }, { "InterPro-ID": "IPR029063", "InterPro-Name": "SAM-dependent_MTases_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 14, "End": 217 } ], "response#1": "MSLQPTATEVGTMYDQYTSLLTDVMAGFIHVGYWDDPEREDTIEVATERLTREIGERLSSVRGQRILDVGCGTGKSAVQIATAHDVHITGITVSNHQIELAQSQYESNTKAGQVNFLFANAMDLPFADASFDGAYAIESLVHMDDRRTALTNIARVLRPGSRLAIADLFLDAGCPNPEVLARFHELFQVPPMPSGDDLKALLHQTGFKVIEFTDIRDTSGLSANF", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Methyltransf_11 that are essential for its biological function; 2. The protein should belong to Erg6_SMT_methyltransf that shares evolutionary origin and functional similarity; 3. The protein should be classified within SAM-dependent_MTases_sf, SAM-dependent_MTases_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MSLQPTATEVGTMYDQYTSLLTDVMAGFIHVGYWDDPEREDTIEVATERLTREIGERLSSVRGQRILDVGCGTGKSAVQIATAHDVHITGITVSNHQIELAQSQYESNTKAGQVNFLFANAMDLPFADASFDGAYAIESLVHMDDRRTALTNIARVLRPGSRLAIADLFLDAGCPNPEVLARFHELFQVPPMPSGDDLKALLHQTGFKVIEFTDIRDTSGLSANF" }, { "InterPro": [ { "InterPro-ID": "IPR023213", "InterPro-Name": "CAT-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 902, "End": 1076 }, { "InterPro-ID": "IPR020806", "InterPro-Name": "PKS_PP-bd", "InterPro-Type": "DOMAIN", "Beg": 801, "End": 872 }, { "InterPro-ID": "IPR006162", "InterPro-Name": "Ppantetheine_attach_site", "InterPro-Type": "PTM", "Beg": 827, "End": 842 }, { "InterPro-ID": "IPR036736", "InterPro-Name": "ACP-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 795, "End": 868 }, { "InterPro-ID": "IPR009081", "InterPro-Name": "PP-bd_ACP", "InterPro-Type": "DOMAIN", "Beg": 803, "End": 867 }, { "InterPro-ID": "IPR001242", "InterPro-Name": "Condensatn", "InterPro-Type": "DOMAIN", "Beg": 909, "End": 1322 }, { "InterPro-ID": "IPR045851", "InterPro-Name": "AMP-bd_C_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 638, "End": 768 }, { "InterPro-ID": "IPR010071", "InterPro-Name": "AA_adenyl_dom", "InterPro-Type": "DOMAIN", "Beg": 261, "End": 659 }, { "InterPro-ID": "IPR020845", "InterPro-Name": "AMP-binding_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 388, "End": 399 }, { "InterPro-ID": "IPR042099", "InterPro-Name": "ANL_N_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 233, "End": 637 }, { "InterPro-ID": "IPR009081", "InterPro-Name": "PP-bd_ACP", "InterPro-Type": "DOMAIN", "Beg": 795, "End": 872 }, { "InterPro-ID": "IPR000873", "InterPro-Name": "AMP-dep_synth/lig_dom", "InterPro-Type": "DOMAIN", "Beg": 239, "End": 586 } ], "response#1": "MSHSSHYSPVDSGMVPSSSSTEDHLSPTLSASIVLPAQLNPFAKAYDIPPSSIVQLGWALLLRCHLAIPSPCWSTIDDKTMPRGSDTHALQWESLHLEEGRSISWILQRWEDPSVHWYLSSDQLPGSKSPTLTTMLFLVKEYGLFDPVTPIDPGMGTIIYFYPSDEQPRLHISWNPDVVSSGHAFHLTRSLEHALQTIFLAPSVDIRDVNLFGIWDHQQLLQWNSYCPDPVDRLVQEMFQDVVAATPEASAVAAWDGELNYRELDRLSSRLAGVLQSDFGVVSETIVALCFEKSVWAIVAMLAVVKAGGAFLHIDPQHPPARHQAMIKSTASKLFLCSEQTRDTVVRSVPDCPSLVIHREMFAAQPDHAQQDTVISSGNLGPTNAAYVVCTSGSTGTPKAIVVEHVSLCSSVTAQAKAMDITAGSRVLQYAAYTFDVSIGDIFAALTHGACICIPSNWERAHDLSGAINRLGVNQACLTSTVASLLTPVEVPKLKKLTLGGEPATQQCINMWVDKVALKNIYGPAECTVWCIIQPDVSSGIAVSNIGHAIGARAWIVHPENHDRLMPIGAVGELLIEGPLVARGYLNDPVRTNAVFLAQPPIWLASFGPPPPRSRFYKTGDLARYGPGGALLFEGRKDTQVKLRGQRIELGEVEYRLHQALSDLSPSAAVELVHPKESTAPLLCAFITWDEGIDLDLQPAKPPLSACLTPNARKRFNHTVSLLQTEMERTLPAYMIPGLCIPVHKLPLTTSGKLDRKALRYFCTQHSLAFLSTFENNNVNSPTDGATDSFAAPLETVSPAESTLAQLWAQVLGRKTDSIGRKDNFLSLGGDSLAAMRLVNRAARDAQLTLTVADVFKCPVLADQASLVRPLVQTRNLVPFELMAPGDLQIEDLVAYVAEKCGVLHDQVEDIYPCTPLQDEMMRDSLSGDRTQMGQEVILLAEDLDIPRYLSACARVFQRFPILRTRFVQHSDRLIQVVIRENLGWQRPESLTEYVEADAKEAPALNKPLTRWALTSDSTHCILTMHHSIFDGISLGHILGAIYAVYQSIPLPPDSVSFAAFLAQINEHTSGLSDDSKQFWRSYLRPSPGSGDLPLPIVDSTYRPCANRGTQRLVTFQSGVVPALQQHGLTEATLIRGAWACTLAQLQTSSSTPSDVVFGTILTGRNLHLPGVDALVAPTLTHAPIRIRMSAASNEKPASFLARVQADATAMIPFEHDGMDRIRAIDAQVRAVCDQMQTLLVIQPIPEGLTSASTSPFPGPILSGPRVEAREMRHFHWYGLLVECTLLPTNGFFVRMCYDDKLFSSEDVERLLDDYSQALHELGGGLTEGEEVHLPTERKLDTLTLPGLVAPSGAEDMV", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more PKS_PP-bd, PP-bd_ACP, Condensatn, AA_adenyl_dom, PP-bd_ACP, AMP-dep_synth/lig_dom that are essential for its biological function; 2. The protein should be classified within CAT-like_dom_sf, ACP-like_sf, AMP-bd_C_sf, ANL_N_sf sharing conserved structural features; 3. The protein should contain AMP-binding_CS that is preserved across related proteins; 4. The protein should contain Ppantetheine_attach_site that allow regulation through chemical modifications. The designed protein sequence is ", "reference": "MSHSSHYSPVDSGMVPSSSSTEDHLSPTLSASIVLPAQLNPFAKAYDIPPSSIVQLGWALLLRCHLAIPSPCWSTIDDKTMPRGSDTHALQWESLHLEEGRSISWILQRWEDPSVHWYLSSDQLPGSKSPTLTTMLFLVKEYGLFDPVTPIDPGMGTIIYFYPSDEQPRLHISWNPDVVSSGHAFHLTRSLEHALQTIFLAPSVDIRDVNLFGIWDHQQLLQWNSYCPDPVDRLVQEMFQDVVAATPEASAVAAWDGELNYRELDRLSSRLAGVLQSDFGVVSETIVALCFEKSVWAIVAMLAVVKAGGAFLHIDPQHPPARHQAMIKSTASKLFLCSEQTRDTVVRSVPDCPSLVIHREMFAAQPDHAQQDTVISSGNLGPTNAAYVVCTSGSTGTPKAIVVEHVSLCSSVTAQAKAMDITAGSRVLQYAAYTFDVSIGDIFAALTHGACICIPSNWERAHDLSGAINRLGVNQACLTSTVASLLTPVEVPKLKKLTLGGEPATQQCINMWVDKVALKNIYGPAECTVWCIIQPDVSSGIAVSNIGHAIGARAWIVHPENHDRLMPIGAVGELLIEGPLVARGYLNDPVRTNAVFLAQPPIWLASFGPPPPRSRFYKTGDLARYGPGGALLFEGRKDTQVKLRGQRIELGEVEYRLHQALSDLSPSAAVELVHPKESTAPLLCAFITWDEGIDLDLQPAKPPLSACLTPNARKRFNHTVSLLQTEMERTLPAYMIPGLCIPVHKLPLTTSGKLDRKALRYFCTQHSLAFLSTFENNNVNSPTDGATDSFAAPLETVSPAESTLAQLWAQVLGRKTDSIGRKDNFLSLGGDSLAAMRLVNRAARDAQLTLTVADVFKCPVLADQASLVRPLVQTRNLVPFELMAPGDLQIEDLVAYVAEKCGVLHDQVEDIYPCTPLQDEMMRDSLSGDRTQMGQEVILLAEDLDIPRYLSACARVFQRFPILRTRFVQHSDRLIQVVIRENLGWQRPESLTEYVEADAKEAPALNKPLTRWALTSDSTHCILTMHHSIFDGISLGHILGAIYAVYQSIPLPPDSVSFAAFLAQINEHTSGLSDDSKQFWRSYLRPSPGSGDLPLPIVDSTYRPCANRGTQRLVTFQSGVVPALQQHGLTEATLIRGAWACTLAQLQTSSSTPSDVVFGTILTGRNLHLPGVDALVAPTLTHAPIRIRMSAASNEKPASFLARVQADATAMIPFEHDGMDRIRAIDAQVRAVCDQMQTLLVIQPIPEGLTSASTSPFPGPILSGPRVEAREMRHFHWYGLLVECTLLPTNGFFVRMCYDDKLFSSEDVERLLDDYSQALHELGGGLTEGEEVHLPTERKLDTLTLPGLVAPSGAEDMV" }, { "InterPro": [ { "InterPro-ID": "IPR036188", "InterPro-Name": "FAD/NAD-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1, "End": 272 }, { "InterPro-ID": "IPR036188", "InterPro-Name": "FAD/NAD-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1, "End": 283 }, { "InterPro-ID": "IPR050346", "InterPro-Name": "FMO-like", "InterPro-Type": "FAMILY", "Beg": 4, "End": 540 }, { "InterPro-ID": "IPR036188", "InterPro-Name": "FAD/NAD-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 344, "End": 537 } ], "response#1": "MYDVIVVGAGWCGLAAAKTYLQTCPTARLLVVDGDSSIGGTWSKERLYPHLVAEAHYGLFEFSDLPMRREGILPDGRIPSAAVHAYLTEYATKFGLLPRIRLNTWIEDIRQDPTAIGDDKAPYWTLQVAGSSQPLQARKLIIATGLTSEPRMPSFPGREDFEGHVLHSKMMGRADTGKLLNDPSIRHVVVYGGSKSAFDAVYLLLRAGKTVDWVIREGGGGPSIMTPLNILGQPSFRLNNSRVMSLFSPNPFEVAGERSWWQRVMHQRAGTFAQLLVVWFWRVLAYLLQRPWKYDYSVNGKQLKPILGLDSVLWSPATLGVMTHPTLWEDIHSGERVTIRRQNITALGQNKHVVLSNGDRITADMVVCATGWHARHSLFTPDEQLAVGLPSTSSFDPKSQAHWLNLQKAADEEILEEFPLLQNCPIALPPVRCEDDHHLYRFVAPSSGPLAQERLIAYVGFLRTTGAPIVYEAQSLWATAYLTGALHVPALEEREKEVARTNAWIRRRYICGRKVPFALFDFLPYVDMLYRDLGVNSRRKKNAVSE", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to FMO-like that shares evolutionary origin and functional similarity; 2. The protein should be classified within FAD/NAD-bd_sf, FAD/NAD-bd_sf, FAD/NAD-bd_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MYDVIVVGAGWCGLAAAKTYLQTCPTARLLVVDGDSSIGGTWSKERLYPHLVAEAHYGLFEFSDLPMRREGILPDGRIPSAAVHAYLTEYATKFGLLPRIRLNTWIEDIRQDPTAIGDDKAPYWTLQVAGSSQPLQARKLIIATGLTSEPRMPSFPGREDFEGHVLHSKMMGRADTGKLLNDPSIRHVVVYGGSKSAFDAVYLLLRAGKTVDWVIREGGGGPSIMTPLNILGQPSFRLNNSRVMSLFSPNPFEVAGERSWWQRVMHQRAGTFAQLLVVWFWRVLAYLLQRPWKYDYSVNGKQLKPILGLDSVLWSPATLGVMTHPTLWEDIHSGERVTIRRQNITALGQNKHVVLSNGDRITADMVVCATGWHARHSLFTPDEQLAVGLPSTSSFDPKSQAHWLNLQKAADEEILEEFPLLQNCPIALPPVRCEDDHHLYRFVAPSSGPLAQERLIAYVGFLRTTGAPIVYEAQSLWATAYLTGALHVPALEEREKEVARTNAWIRRRYICGRKVPFALFDFLPYVDMLYRDLGVNSRRKKNAVSE" }, { "InterPro": [ { "InterPro-ID": "IPR050346", "InterPro-Name": "FMO-like", "InterPro-Type": "FAMILY", "Beg": 4, "End": 552 }, { "InterPro-ID": "IPR036188", "InterPro-Name": "FAD/NAD-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1, "End": 278 }, { "InterPro-ID": "IPR036188", "InterPro-Name": "FAD/NAD-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 336, "End": 563 }, { "InterPro-ID": "IPR036188", "InterPro-Name": "FAD/NAD-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1, "End": 227 } ], "response#1": "MYDVIVIGAGWCGLVAAKTYLQVCPDARLLLVDGDSSIGGTWSKERLYPHLVAEAHHGLFEFSDLPMRRDTVLPDGRIPSAAVHDYLTEYATKFDLIDRIRLNTWIENVRREPAVIGDNEAPRWMLTVAGSCEQIPTKKIIIATGLTSEPYMPFLPGRQEFEGEVLHSKALGHPQTGDRISDPSVRHAVVYGGSKSAFDAVYLLLRAGKTVDWVIREQGGGPSMMTPLSILGQPSFRLNNSRLLALFSPHPFDTTVKASWWQRVMHRRSGRLAQLAVIGFWRILAYLLQRPWKYNQSANGRRLRPLLALDSLFWSPATLGVMTHPELWDDIHSGERVTIHRQAITALGKDKRVILDNGVELSADLVVCATGWHARHTLFKPEEQLAVGLPSAVSFDPKSQSEWINLQRKADQEIIEEMPILQKSPVPSVPFRCEDDYHLYRFIAPSREPPSHERSIAYVGFLRTAGAPIVYEAQSLWATAYLTGALDVPGPSERISEVARTNAWIRRRYICGRKVPFALFDFLPYVDMLYRDLGVNPHRKANMVAEICGLYQPRDFQGVVSEWLASRGVKDIENV", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to FMO-like that shares evolutionary origin and functional similarity; 2. The protein should be classified within FAD/NAD-bd_sf, FAD/NAD-bd_sf, FAD/NAD-bd_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MYDVIVIGAGWCGLVAAKTYLQVCPDARLLLVDGDSSIGGTWSKERLYPHLVAEAHHGLFEFSDLPMRRDTVLPDGRIPSAAVHDYLTEYATKFDLIDRIRLNTWIENVRREPAVIGDNEAPRWMLTVAGSCEQIPTKKIIIATGLTSEPYMPFLPGRQEFEGEVLHSKALGHPQTGDRISDPSVRHAVVYGGSKSAFDAVYLLLRAGKTVDWVIREQGGGPSMMTPLSILGQPSFRLNNSRLLALFSPHPFDTTVKASWWQRVMHRRSGRLAQLAVIGFWRILAYLLQRPWKYNQSANGRRLRPLLALDSLFWSPATLGVMTHPELWDDIHSGERVTIHRQAITALGKDKRVILDNGVELSADLVVCATGWHARHTLFKPEEQLAVGLPSAVSFDPKSQSEWINLQRKADQEIIEEMPILQKSPVPSVPFRCEDDYHLYRFIAPSREPPSHERSIAYVGFLRTAGAPIVYEAQSLWATAYLTGALDVPGPSERISEVARTNAWIRRRYICGRKVPFALFDFLPYVDMLYRDLGVNPHRKANMVAEICGLYQPRDFQGVVSEWLASRGVKDIENV" }, { "InterPro": [ { "InterPro-ID": "IPR004111", "InterPro-Name": "Repressor_TetR_C", "InterPro-Type": "DOMAIN", "Beg": 112, "End": 259 }, { "InterPro-ID": "IPR001647", "InterPro-Name": "HTH_TetR", "InterPro-Type": "DOMAIN", "Beg": 49, "End": 109 }, { "InterPro-ID": "IPR050109", "InterPro-Name": "HTH-type_TetR-like_transc_reg", "InterPro-Type": "FAMILY", "Beg": 39, "End": 144 }, { "InterPro-ID": "IPR009057", "InterPro-Name": "Homeodomain-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 44, "End": 107 }, { "InterPro-ID": "IPR001647", "InterPro-Name": "HTH_TetR", "InterPro-Type": "DOMAIN", "Beg": 56, "End": 99 }, { "InterPro-ID": "IPR036271", "InterPro-Name": "Tet_transcr_reg_TetR-rel_C_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 118, "End": 264 } ], "response#1": "MESGTSRTSDTGGTGRAGSTETSGSGDIARTLELLWDTGRRPSRGPKPTLTLDRVVEAAVQIADAEGLEGLSMRRVAAELGTGTMSLYRYVPGKGELLDLMLDRVQRPSENPADLGDGGWRAALEAMARETLALYRRHPWLLQVNQSRPILGPSAMDGMEKVLTLIRPMGLTDPELVSAIIMIDGYVVGAARSQLYQQEAERRTGLTDAEFWRAQVPMLEKVLASGRYPVMASLSEDTFGPDFDHFGFGLQRILDGLEVLVAQRRGESAP", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Repressor_TetR_C, HTH_TetR, HTH_TetR that are essential for its biological function; 2. The protein should belong to HTH-type_TetR-like_transc_reg that shares evolutionary origin and functional similarity; 3. The protein should be classified within Homeodomain-like_sf, Tet_transcr_reg_TetR-rel_C_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MESGTSRTSDTGGTGRAGSTETSGSGDIARTLELLWDTGRRPSRGPKPTLTLDRVVEAAVQIADAEGLEGLSMRRVAAELGTGTMSLYRYVPGKGELLDLMLDRVQRPSENPADLGDGGWRAALEAMARETLALYRRHPWLLQVNQSRPILGPSAMDGMEKVLTLIRPMGLTDPELVSAIIMIDGYVVGAARSQLYQQEAERRTGLTDAEFWRAQVPMLEKVLASGRYPVMASLSEDTFGPDFDHFGFGLQRILDGLEVLVAQRRGESAP" }, { "InterPro": [ { "InterPro-ID": "IPR050954", "InterPro-Name": "ET_IronSulfur_Cluster-Binding", "InterPro-Type": "FAMILY", "Beg": 79, "End": 291 }, { "InterPro-ID": "IPR017900", "InterPro-Name": "4Fe4S_Fe_S_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 170, "End": 181 }, { "InterPro-ID": "IPR017896", "InterPro-Name": "4Fe4S_Fe-S-bd", "InterPro-Type": "DOMAIN", "Beg": 84, "End": 113 }, { "InterPro-ID": "IPR006311", "InterPro-Name": "TAT_signal", "InterPro-Type": "CONSERVED_SITE", "Beg": 1, "End": 43 }, { "InterPro-ID": "IPR017896", "InterPro-Name": "4Fe4S_Fe-S-bd", "InterPro-Type": "DOMAIN", "Beg": 161, "End": 190 }, { "InterPro-ID": "IPR017896", "InterPro-Name": "4Fe4S_Fe-S-bd", "InterPro-Type": "DOMAIN", "Beg": 220, "End": 258 }, { "InterPro-ID": "IPR017896", "InterPro-Name": "4Fe4S_Fe-S-bd", "InterPro-Type": "DOMAIN", "Beg": 131, "End": 192 } ], "response#1": "MGSKETKNTSRRDFLIKGAGAAALGAGAFAISQVPLLEKLASANEDTVKDLLPFPELIESDEIIIRMQNDVRRALKKPLNEIQWIMVIDLKKCVGCSSCTVACVSENVLPPGVVYRPVIEEEIGTFPNVTKKFTPRPCMQCEHPPCTKVCPIGATYKSEDGIVAIDYDKCIGCRYCITACPYGARTFDWGEYHTENTPEIMQYEKEPNYEYGVERVREKKNSPIGNARKCHFCKHRLHKGMLSMCVTTCIGRATYIGDKNDPESLVAELIASPRVMRLKEELGTEPNVYYLT", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more 4Fe4S_Fe-S-bd, 4Fe4S_Fe-S-bd, 4Fe4S_Fe-S-bd, 4Fe4S_Fe-S-bd that are essential for its biological function; 2. The protein should belong to ET_IronSulfur_Cluster-Binding that shares evolutionary origin and functional similarity; 3. The protein should contain 4Fe4S_Fe_S_CS, TAT_signal that is preserved across related proteins. The designed protein sequence is ", "reference": "MGSKETKNTSRRDFLIKGAGAAALGAGAFAISQVPLLEKLASANEDTVKDLLPFPELIESDEIIIRMQNDVRRALKKPLNEIQWIMVIDLKKCVGCSSCTVACVSENVLPPGVVYRPVIEEEIGTFPNVTKKFTPRPCMQCEHPPCTKVCPIGATYKSEDGIVAIDYDKCIGCRYCITACPYGARTFDWGEYHTENTPEIMQYEKEPNYEYGVERVREKKNSPIGNARKCHFCKHRLHKGMLSMCVTTCIGRATYIGDKNDPESLVAELIASPRVMRLKEELGTEPNVYYLT" }, { "InterPro": [ { "InterPro-ID": "IPR052049", "InterPro-Name": "Electron_transfer_protein", "InterPro-Type": "FAMILY", "Beg": 34, "End": 392 }, { "InterPro-ID": "IPR005614", "InterPro-Name": "NrfD-like", "InterPro-Type": "FAMILY", "Beg": 38, "End": 354 } ], "response#1": "MLKKLYFTVLSFIAIVGVISLYIRLSEGMKMSALTSYSSWGLWIVFYIYFIGLSAGSFLLSTMVYVFNMKQFERIGKLALFTAFFSLMAGLLFVLIDLGHPERFWHTLVYRQPNSILSWEIQFYLIYMLLIVAEIWFLMREEFAQRAQSTKGLTKLFNRTLTLGYKVPNSQQKLEFHREQSHKWMKILGIAGIPTAVGVHGGTGSLFGVVMAKEYWFSGLTPIIFLVSALVSGAALMLFLYSFFGGAKKNGDSLLKELGTLLTLFIGIDLLLMIAEFLIGLYNPIHHERMTFNEILFGDRWFIFWIGQIGMVIILPILLITISKGKRLLMGLAGLSVVLGIVCVRWILVIPAYVAPHFDGLDSAYNSSRLLYEYSPNLLEWSSSVGLIGIVILLFSITVQLVPVFNKQKEVHQTHGKPTPEIHIKA", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Electron_transfer_protein, NrfD-like that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MLKKLYFTVLSFIAIVGVISLYIRLSEGMKMSALTSYSSWGLWIVFYIYFIGLSAGSFLLSTMVYVFNMKQFERIGKLALFTAFFSLMAGLLFVLIDLGHPERFWHTLVYRQPNSILSWEIQFYLIYMLLIVAEIWFLMREEFAQRAQSTKGLTKLFNRTLTLGYKVPNSQQKLEFHREQSHKWMKILGIAGIPTAVGVHGGTGSLFGVVMAKEYWFSGLTPIIFLVSALVSGAALMLFLYSFFGGAKKNGDSLLKELGTLLTLFIGIDLLLMIAEFLIGLYNPIHHERMTFNEILFGDRWFIFWIGQIGMVIILPILLITISKGKRLLMGLAGLSVVLGIVCVRWILVIPAYVAPHFDGLDSAYNSSRLLYEYSPNLLEWSSSVGLIGIVILLFSITVQLVPVFNKQKEVHQTHGKPTPEIHIKA" }, { "InterPro": [ { "InterPro-ID": "IPR026571", "InterPro-Name": "Tmem186", "InterPro-Type": "FAMILY", "Beg": 6, "End": 204 }, { "InterPro-ID": "IPR045325", "InterPro-Name": "TMEM70/TMEM186/TMEM223", "InterPro-Type": "FAMILY", "Beg": 68, "End": 203 } ], "response#1": "MLELLCRVSPARLPWRSCMSLAIQPAQRRRFATEAAGKRTETEKSAFTEWRTVYSMPGIRLVAALSRLKVYQAVITAAGTPIVFALGSAGQLSTDALAIYAAIGVTGLITLTLASYASSNLVGFIYVNEEQDLLKLAYVDFWGRRQETLIETEDLLPSWEQGSPSRLRFVSPICLRSDSKRRYKLLNRFGHVSDRQLFEGLFGN", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Tmem186, TMEM70/TMEM186/TMEM223 that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MLELLCRVSPARLPWRSCMSLAIQPAQRRRFATEAAGKRTETEKSAFTEWRTVYSMPGIRLVAALSRLKVYQAVITAAGTPIVFALGSAGQLSTDALAIYAAIGVTGLITLTLASYASSNLVGFIYVNEEQDLLKLAYVDFWGRRQETLIETEDLLPSWEQGSPSRLRFVSPICLRSDSKRRYKLLNRFGHVSDRQLFEGLFGN" }, { "InterPro": [ { "InterPro-ID": "IPR036188", "InterPro-Name": "FAD/NAD-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1, "End": 220 }, { "InterPro-ID": "IPR050346", "InterPro-Name": "FMO-like", "InterPro-Type": "FAMILY", "Beg": 4, "End": 547 }, { "InterPro-ID": "IPR036188", "InterPro-Name": "FAD/NAD-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 309, "End": 562 }, { "InterPro-ID": "IPR036188", "InterPro-Name": "FAD/NAD-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1, "End": 267 } ], "response#1": "MYDVIVIGAGWCGLVAAKTYLQACPDAQVLIVDGDTSIGGTWSKERLYPHLVAEAHYGLFEFSDLPMNGDSVLPDGRIPSTAVHAYLVEYATKFNLIQRIRLNTWIENVRREAGELGMHWTLTAAGSQEQLHAKKVIITTGLTSEAFIPSLPGRDEFEGEVLHSKALGHPQTVERISDPSIRHVVVYGGSKSAFDAVYLLLRAGKTVDWVIREGGGGPSMMTPLSVLGQPSFRLNNSRLLALLSPHPFGTPGEQLSWWQRVVHHRSGQWAQFMILTIWRVMNYLFLRPWGYDSSPNGKRLKPLLGLDSLFWSPATLGVMTHPELWEEIHSGQRVKIHRDAITGLARDKRVMLSSGQELSSADLVVCATGWHARHSFFAPEEQLAVGLPGTASFDPKSQQKWLDLQRTADREITEELPILQKNPIPPPPLRCEDDHHLYRFIAPSRETPSHERSIAFVGFLRTAGAPIVYEAQSLWATAYLTGALEVPEAPQREREIARTNAWIRRRYLCGRKVPFALFDFLPYVDMLYRDLGINPNRKPNQIAELCGLYRPQDFKGVVSEWLANQQAKDVNGN", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to FMO-like that shares evolutionary origin and functional similarity; 2. The protein should be classified within FAD/NAD-bd_sf, FAD/NAD-bd_sf, FAD/NAD-bd_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MYDVIVIGAGWCGLVAAKTYLQACPDAQVLIVDGDTSIGGTWSKERLYPHLVAEAHYGLFEFSDLPMNGDSVLPDGRIPSTAVHAYLVEYATKFNLIQRIRLNTWIENVRREAGELGMHWTLTAAGSQEQLHAKKVIITTGLTSEAFIPSLPGRDEFEGEVLHSKALGHPQTVERISDPSIRHVVVYGGSKSAFDAVYLLLRAGKTVDWVIREGGGGPSMMTPLSVLGQPSFRLNNSRLLALLSPHPFGTPGEQLSWWQRVVHHRSGQWAQFMILTIWRVMNYLFLRPWGYDSSPNGKRLKPLLGLDSLFWSPATLGVMTHPELWEEIHSGQRVKIHRDAITGLARDKRVMLSSGQELSSADLVVCATGWHARHSFFAPEEQLAVGLPGTASFDPKSQQKWLDLQRTADREITEELPILQKNPIPPPPLRCEDDHHLYRFIAPSRETPSHERSIAFVGFLRTAGAPIVYEAQSLWATAYLTGALEVPEAPQREREIARTNAWIRRRYLCGRKVPFALFDFLPYVDMLYRDLGINPNRKPNQIAELCGLYRPQDFKGVVSEWLANQQAKDVNGN" }, { "InterPro": [ { "InterPro-ID": "IPR002912", "InterPro-Name": "ACT_dom", "InterPro-Type": "DOMAIN", "Beg": 463, "End": 535 }, { "InterPro-ID": "IPR036393", "InterPro-Name": "AceGlu_kinase-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 34, "End": 343 }, { "InterPro-ID": "IPR018042", "InterPro-Name": "Aspartate_kinase_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 36, "End": 44 }, { "InterPro-ID": "IPR001341", "InterPro-Name": "Asp_kinase", "InterPro-Type": "FAMILY", "Beg": 34, "End": 522 }, { "InterPro-ID": "IPR045865", "InterPro-Name": "ACT-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 373, "End": 465 }, { "InterPro-ID": "IPR001048", "InterPro-Name": "Asp/Glu/Uridylate_kinase", "InterPro-Type": "DOMAIN", "Beg": 34, "End": 329 }, { "InterPro-ID": "IPR054352", "InterPro-Name": "ACT_Aspartokinase", "InterPro-Type": "DOMAIN", "Beg": 461, "End": 520 }, { "InterPro-ID": "IPR036393", "InterPro-Name": "AceGlu_kinase-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 34, "End": 344 }, { "InterPro-ID": "IPR045865", "InterPro-Name": "ACT-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 448, "End": 524 } ], "response#1": "MSQSPTNVPRSYNSVLDLKLASPTNSASGATGGWIVQKFGGTSVGKFPENIVDNIVKVYSQTNRVAVVCSARSSQTKSEGTTSRLLRSADLAENDKDYQPLLNAIEEDHVTNAERIQSEEIKQELIKDTKQEIEHVRELLHACQIIGEISPRSLDSIMAVGEKLSCLFMTALMKDHGLNAVYINLQDVIPLSYDFQKGFDDSFYQFLSQEIGKRVLQCDKEREGEEDVIPVLTGYFGVVPGGLLNGVGRGYTDLCAALAAVALQADELQIWKEVDGIFTADPRKVPNARLLDSVTPEEAAELTYYGSEVIHPFTMEQVIRAKIPIRIKNVENPTGKGTIIYPDNIGRRGEATPPHPPAAFEQLAMSSLLQRKRSATAITAKQDIVVINIHSNKKTLSHGFLAHVFTTLDKYKLVVDLISTSEVHVSMALSIQSDQESQLKHALVDLRKMGTVDVTKKMTIVSLVGKQMVNFIGIAGNMFKVLADEKINIEMISQGANEINISAVINEKDTIRALKSIHAKLLEGGSAIGDSSAVDTRLEALKLS", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more ACT_dom, Asp/Glu/Uridylate_kinase, ACT_Aspartokinase that are essential for its biological function; 2. The protein should belong to Asp_kinase that shares evolutionary origin and functional similarity; 3. The protein should be classified within AceGlu_kinase-like_sf, ACT-like_dom_sf, AceGlu_kinase-like_sf, ACT-like_dom_sf sharing conserved structural features; 4. The protein should contain Aspartate_kinase_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MSQSPTNVPRSYNSVLDLKLASPTNSASGATGGWIVQKFGGTSVGKFPENIVDNIVKVYSQTNRVAVVCSARSSQTKSEGTTSRLLRSADLAENDKDYQPLLNAIEEDHVTNAERIQSEEIKQELIKDTKQEIEHVRELLHACQIIGEISPRSLDSIMAVGEKLSCLFMTALMKDHGLNAVYINLQDVIPLSYDFQKGFDDSFYQFLSQEIGKRVLQCDKEREGEEDVIPVLTGYFGVVPGGLLNGVGRGYTDLCAALAAVALQADELQIWKEVDGIFTADPRKVPNARLLDSVTPEEAAELTYYGSEVIHPFTMEQVIRAKIPIRIKNVENPTGKGTIIYPDNIGRRGEATPPHPPAAFEQLAMSSLLQRKRSATAITAKQDIVVINIHSNKKTLSHGFLAHVFTTLDKYKLVVDLISTSEVHVSMALSIQSDQESQLKHALVDLRKMGTVDVTKKMTIVSLVGKQMVNFIGIAGNMFKVLADEKINIEMISQGANEINISAVINEKDTIRALKSIHAKLLEGGSAIGDSSAVDTRLEALKLS" }, { "InterPro": [ { "InterPro-ID": "IPR009081", "InterPro-Name": "PP-bd_ACP", "InterPro-Type": "DOMAIN", "Beg": 779, "End": 856 }, { "InterPro-ID": "IPR036736", "InterPro-Name": "ACP-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 781, "End": 852 }, { "InterPro-ID": "IPR036736", "InterPro-Name": "ACP-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 779, "End": 852 }, { "InterPro-ID": "IPR006162", "InterPro-Name": "Ppantetheine_attach_site", "InterPro-Type": "PTM", "Beg": 811, "End": 826 }, { "InterPro-ID": "IPR023213", "InterPro-Name": "CAT-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 888, "End": 1059 }, { "InterPro-ID": "IPR009081", "InterPro-Name": "PP-bd_ACP", "InterPro-Type": "DOMAIN", "Beg": 788, "End": 852 }, { "InterPro-ID": "IPR001242", "InterPro-Name": "Condensatn", "InterPro-Type": "DOMAIN", "Beg": 893, "End": 1312 }, { "InterPro-ID": "IPR020806", "InterPro-Name": "PKS_PP-bd", "InterPro-Type": "DOMAIN", "Beg": 785, "End": 856 }, { "InterPro-ID": "IPR045851", "InterPro-Name": "AMP-bd_C_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 623, "End": 755 }, { "InterPro-ID": "IPR000873", "InterPro-Name": "AMP-dep_synth/lig_dom", "InterPro-Type": "DOMAIN", "Beg": 226, "End": 571 }, { "InterPro-ID": "IPR020845", "InterPro-Name": "AMP-binding_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 373, "End": 384 }, { "InterPro-ID": "IPR010071", "InterPro-Name": "AA_adenyl_dom", "InterPro-Type": "DOMAIN", "Beg": 247, "End": 644 }, { "InterPro-ID": "IPR042099", "InterPro-Name": "ANL_N_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 220, "End": 622 } ], "response#1": "MSPHISPSKDTPSQRLPIPLSLPTHLGLLAKAYGVPPASILQLAWGLVLRCYFTTSSSRWGTIDMAHEYKEKKNLPIRCEVLELDDTRSIGWILQNWNDPSVHRHLPAEEDTSNVPVSAGSIVILTEDAKDLEVLRDFELTAEWIICFSTSTEKPLLRLSWRPDVIHSELASHLAQLLERALDTTFLSPDIPLSQINLFSILDHQKLLQWNHQYPQSVNRLVHEMFEDMVAARPQATAVAAWDGEVTYQQLDRLSTRLAIKLQTIDLQPESIVALCFEKSVWAIVAMLGVLRAGGAFLHIDPKHPTARQQAMISTTAARIILCSEQTRDTVSRFDSESLSLVVDRKMFAQEPDHKQVALPSPNNLGPRNAAYIVCTSGSTGLPKAIVVEHVSLCTSVTAQAEAMAVGGESRILQYAAYTFDVSVGDVFTALTHGACVCIPSDWERTQDLVGAINRLDVNQACLTSTVASFLTPMNVPKLQKLTLGGEPASKQCIDLWSGKVALKNVYGPAECTVWCVIQKNASSEIPASNIGRGIGARTWIVHPENHNQLMPIGAVGELLIEGPLVARGYLNDAERTTAVFLERAPSWLATFGPLPPQTRFYKTGDLARFEQNGTLFFEGRKDTQVKLRGQRIELGEIEYQIQQACNPVPPLAVELIETKDLQAPLLGAFITWTGGLEISLDQSAVPNGLGPDLDARSHFNELVSRIQANIDRTLPPYMMPGLYIPVQKLPLSTSGKLDRKVLRQYCTQHTRSFLTASEAESSDVIADDATKDDVALHEIVNPGEITLAQLWAHALGRRMESINAKDNFLSLGGDSLAAMRLVNLAARDAQVTLTVANIFESPVLADQARLLRPLSKTKSLAPFELMTRGEASIEDIVGFAAQQCRLLPAQIEDVYPCTPLQEEMMRDSLSNDRTQMGQEVVQISEELDLVRYQVACASVYRRFPILRTRFIEHSGRLVQVVVREDLCWKQPTSLAEYKALDSRERPALGKPLTRWALTSDGTHFILSLHHAMFDGITLGQIQGAIYAVYQCIPLPPPSVSFATFLAHLDDQNAPLSQESQRFWQSYLCPSASLDASITPETQKIDRPRASCGTQRLVQFTSGEVSALQRHGLTEATLVRGAWACTLARHQQKPHASAFSDVIFGTMLTGRNFHLPGVDMLAAPSLTHVPIRIRIDEGDLNGHSARALLARVQADATAMIPYEHDGMNRIRSIEVQTRAVFNRIRTLLVIQPIPEGLTSVSTSPFPGSIVSGPRVEAKEMGHFHWYGLLVECTLLPTKGFFVRVSYDNKMFGTEQVESLLDDYSTTLHTLANGLMDTDIPASLHV", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more PP-bd_ACP, PP-bd_ACP, Condensatn, PKS_PP-bd, AMP-dep_synth/lig_dom, AA_adenyl_dom that are essential for its biological function; 2. The protein should be classified within ACP-like_sf, ACP-like_sf, CAT-like_dom_sf, AMP-bd_C_sf, ANL_N_sf sharing conserved structural features; 3. The protein should contain AMP-binding_CS that is preserved across related proteins; 4. The protein should contain Ppantetheine_attach_site that allow regulation through chemical modifications. The designed protein sequence is ", "reference": "MSPHISPSKDTPSQRLPIPLSLPTHLGLLAKAYGVPPASILQLAWGLVLRCYFTTSSSRWGTIDMAHEYKEKKNLPIRCEVLELDDTRSIGWILQNWNDPSVHRHLPAEEDTSNVPVSAGSIVILTEDAKDLEVLRDFELTAEWIICFSTSTEKPLLRLSWRPDVIHSELASHLAQLLERALDTTFLSPDIPLSQINLFSILDHQKLLQWNHQYPQSVNRLVHEMFEDMVAARPQATAVAAWDGEVTYQQLDRLSTRLAIKLQTIDLQPESIVALCFEKSVWAIVAMLGVLRAGGAFLHIDPKHPTARQQAMISTTAARIILCSEQTRDTVSRFDSESLSLVVDRKMFAQEPDHKQVALPSPNNLGPRNAAYIVCTSGSTGLPKAIVVEHVSLCTSVTAQAEAMAVGGESRILQYAAYTFDVSVGDVFTALTHGACVCIPSDWERTQDLVGAINRLDVNQACLTSTVASFLTPMNVPKLQKLTLGGEPASKQCIDLWSGKVALKNVYGPAECTVWCVIQKNASSEIPASNIGRGIGARTWIVHPENHNQLMPIGAVGELLIEGPLVARGYLNDAERTTAVFLERAPSWLATFGPLPPQTRFYKTGDLARFEQNGTLFFEGRKDTQVKLRGQRIELGEIEYQIQQACNPVPPLAVELIETKDLQAPLLGAFITWTGGLEISLDQSAVPNGLGPDLDARSHFNELVSRIQANIDRTLPPYMMPGLYIPVQKLPLSTSGKLDRKVLRQYCTQHTRSFLTASEAESSDVIADDATKDDVALHEIVNPGEITLAQLWAHALGRRMESINAKDNFLSLGGDSLAAMRLVNLAARDAQVTLTVANIFESPVLADQARLLRPLSKTKSLAPFELMTRGEASIEDIVGFAAQQCRLLPAQIEDVYPCTPLQEEMMRDSLSNDRTQMGQEVVQISEELDLVRYQVACASVYRRFPILRTRFIEHSGRLVQVVVREDLCWKQPTSLAEYKALDSRERPALGKPLTRWALTSDGTHFILSLHHAMFDGITLGQIQGAIYAVYQCIPLPPPSVSFATFLAHLDDQNAPLSQESQRFWQSYLCPSASLDASITPETQKIDRPRASCGTQRLVQFTSGEVSALQRHGLTEATLVRGAWACTLARHQQKPHASAFSDVIFGTMLTGRNFHLPGVDMLAAPSLTHVPIRIRIDEGDLNGHSARALLARVQADATAMIPYEHDGMNRIRSIEVQTRAVFNRIRTLLVIQPIPEGLTSVSTSPFPGSIVSGPRVEAKEMGHFHWYGLLVECTLLPTKGFFVRVSYDNKMFGTEQVESLLDDYSTTLHTLANGLMDTDIPASLHV" }, { "InterPro": [ { "InterPro-ID": "IPR003953", "InterPro-Name": "FAD-dep_OxRdtase_2_FAD-bd", "InterPro-Type": "DOMAIN", "Beg": 16, "End": 45 }, { "InterPro-ID": "IPR002938", "InterPro-Name": "FAD-bd", "InterPro-Type": "DOMAIN", "Beg": 121, "End": 368 }, { "InterPro-ID": "IPR036188", "InterPro-Name": "FAD/NAD-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 15, "End": 392 }, { "InterPro-ID": "IPR050493", "InterPro-Name": "FAD-dep_Monooxygenase_BioMet", "InterPro-Type": "FAMILY", "Beg": 5, "End": 418 }, { "InterPro-ID": "IPR036188", "InterPro-Name": "FAD/NAD-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 16, "End": 394 } ], "response#1": "MTVHSAESNGSNRIVIIIVGLGIAGLSAAIECHGKGHQVMVFEKYSDLKRTEGDGISIGSNGARVSAKWGDGTFHELIRPLEYQTNKAKVSDYTGYSYGTFELHGYNEGRGYTVNRGQLVYAMHEYARSLGIPIFLNSEVTGYWETEDEAGVVVDGKRISADCVVCAEGIHSSGRLIITGQKMELKETGYAASRGYLDACVTSQDSKLNWILGEEEAEAEDCVYGWLGPGVHFGITTKKRENELFWYCSHKDACTPSKDIDGTINQILHCMEGWAARDQLETVMRKAKKGRFVSETLAIRTPLATWLSPKRRMIVIGDAAHAALPSSGQGGTQAIEDAATLAICLELAGKKDVALALSVTEKLRHQRAQIVQQGGLAVLQFVMNHVDFEALRTDPTMVKPPHPAWILDHDCQEYAYREFVKAAEAIQDGEEYVPHNIPRDGKYSMEYNSQ", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more FAD-dep_OxRdtase_2_FAD-bd, FAD-bd that are essential for its biological function; 2. The protein should belong to FAD-dep_Monooxygenase_BioMet that shares evolutionary origin and functional similarity; 3. The protein should be classified within FAD/NAD-bd_sf, FAD/NAD-bd_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MTVHSAESNGSNRIVIIIVGLGIAGLSAAIECHGKGHQVMVFEKYSDLKRTEGDGISIGSNGARVSAKWGDGTFHELIRPLEYQTNKAKVSDYTGYSYGTFELHGYNEGRGYTVNRGQLVYAMHEYARSLGIPIFLNSEVTGYWETEDEAGVVVDGKRISADCVVCAEGIHSSGRLIITGQKMELKETGYAASRGYLDACVTSQDSKLNWILGEEEAEAEDCVYGWLGPGVHFGITTKKRENELFWYCSHKDACTPSKDIDGTINQILHCMEGWAARDQLETVMRKAKKGRFVSETLAIRTPLATWLSPKRRMIVIGDAAHAALPSSGQGGTQAIEDAATLAICLELAGKKDVALALSVTEKLRHQRAQIVQQGGLAVLQFVMNHVDFEALRTDPTMVKPPHPAWILDHDCQEYAYREFVKAAEAIQDGEEYVPHNIPRDGKYSMEYNSQ" }, { "InterPro": [ { "InterPro-ID": "IPR012148", "InterPro-Name": "DMATS-type_fun", "InterPro-Type": "FAMILY", "Beg": 2, "End": 428 }, { "InterPro-ID": "IPR017795", "InterPro-Name": "Aro_prenylTrfase_DMATS", "InterPro-Type": "FAMILY", "Beg": 6, "End": 415 }, { "InterPro-ID": "IPR017795", "InterPro-Name": "Aro_prenylTrfase_DMATS", "InterPro-Type": "FAMILY", "Beg": 27, "End": 373 }, { "InterPro-ID": "IPR017795", "InterPro-Name": "Aro_prenylTrfase_DMATS", "InterPro-Type": "FAMILY", "Beg": 30, "End": 414 }, { "InterPro-ID": "IPR033964", "InterPro-Name": "Aro_prenylTrfase", "InterPro-Type": "FAMILY", "Beg": 11, "End": 420 }, { "InterPro-ID": "IPR017795", "InterPro-Name": "Aro_prenylTrfase_DMATS", "InterPro-Type": "FAMILY", "Beg": 16, "End": 412 } ], "response#1": "MTVTKEAPEVMPFEGLTEEINLMSDNERVWWQKTGSMLSRVLSSADYTWKEQHKHLKFYAQVLLPHLGPYPQSFRSSITRSGLPFELSINYQQNGNPLVVRIGFEPLNALSGTPDDPFNQAPAAEVLSLLDQMHIPGFDSQIWDKAVEHHTVNHTEREALRDSDLGAGYIRSQTAYGFDLLRDGNIAVKGYSFPALKCQITGQSMAQMMAGLVADLAPLVDCSQAFAIVDEYLQDTGYDERAFFSWDFVEPSRSRLKLYTGSSSVTWGKLAEVWTLGNRVQNPTVARGLEYLRQLFDLIKLSDGQRNIVVAFDDRQDSSKETPLLWNYEMRAGDPTPLTKIYFPVHGENDLQVINGVAEFLCQIGLSHGKTYVEKVKSYYPGIDLSTTERFTSWVSFAYTEKTGVYLSTYYHSSTDNPWKMTTEEDSQL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to DMATS-type_fun, Aro_prenylTrfase_DMATS, Aro_prenylTrfase_DMATS, Aro_prenylTrfase_DMATS, Aro_prenylTrfase, Aro_prenylTrfase_DMATS that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MTVTKEAPEVMPFEGLTEEINLMSDNERVWWQKTGSMLSRVLSSADYTWKEQHKHLKFYAQVLLPHLGPYPQSFRSSITRSGLPFELSINYQQNGNPLVVRIGFEPLNALSGTPDDPFNQAPAAEVLSLLDQMHIPGFDSQIWDKAVEHHTVNHTEREALRDSDLGAGYIRSQTAYGFDLLRDGNIAVKGYSFPALKCQITGQSMAQMMAGLVADLAPLVDCSQAFAIVDEYLQDTGYDERAFFSWDFVEPSRSRLKLYTGSSSVTWGKLAEVWTLGNRVQNPTVARGLEYLRQLFDLIKLSDGQRNIVVAFDDRQDSSKETPLLWNYEMRAGDPTPLTKIYFPVHGENDLQVINGVAEFLCQIGLSHGKTYVEKVKSYYPGIDLSTTERFTSWVSFAYTEKTGVYLSTYYHSSTDNPWKMTTEEDSQL" }, { "InterPro": [ { "InterPro-ID": "IPR000725", "InterPro-Name": "Olfact_rcpt", "InterPro-Type": "FAMILY", "Beg": 92, "End": 103 }, { "InterPro-ID": "IPR000725", "InterPro-Name": "Olfact_rcpt", "InterPro-Type": "FAMILY", "Beg": 236, "End": 245 }, { "InterPro-ID": "IPR000725", "InterPro-Name": "Olfact_rcpt", "InterPro-Type": "FAMILY", "Beg": 281, "End": 292 }, { "InterPro-ID": "IPR000725", "InterPro-Name": "Olfact_rcpt", "InterPro-Type": "FAMILY", "Beg": 176, "End": 192 }, { "InterPro-ID": "IPR000725", "InterPro-Name": "Olfact_rcpt", "InterPro-Type": "FAMILY", "Beg": 129, "End": 141 }, { "InterPro-ID": "IPR000276", "InterPro-Name": "GPCR_Rhodpsn", "InterPro-Type": "FAMILY", "Beg": 110, "End": 126 }, { "InterPro-ID": "IPR017452", "InterPro-Name": "GPCR_Rhodpsn_7TM", "InterPro-Type": "DOMAIN", "Beg": 41, "End": 288 }, { "InterPro-ID": "IPR000276", "InterPro-Name": "GPCR_Rhodpsn", "InterPro-Type": "FAMILY", "Beg": 26, "End": 50 }, { "InterPro-ID": "IPR000276", "InterPro-Name": "GPCR_Rhodpsn", "InterPro-Type": "FAMILY", "Beg": 59, "End": 80 }, { "InterPro-ID": "IPR000276", "InterPro-Name": "GPCR_Rhodpsn", "InterPro-Type": "FAMILY", "Beg": 104, "End": 126 }, { "InterPro-ID": "IPR000276", "InterPro-Name": "GPCR_Rhodpsn", "InterPro-Type": "FAMILY", "Beg": 270, "End": 296 }, { "InterPro-ID": "IPR050516", "InterPro-Name": "Olfactory_GPCR", "InterPro-Type": "FAMILY", "Beg": 5, "End": 301 }, { "InterPro-ID": "IPR000725", "InterPro-Name": "Olfact_rcpt", "InterPro-Type": "FAMILY", "Beg": 31, "End": 306 } ], "response#1": "MEVSNMTTVTVFILLGLSNNPQVQALLFVLFLVIYLLTLLGNLLMVLVISTDSHLCTPMYFFLRQLSFLDAFYSSIIVPKLLENLLSKGETISFLECFTQISLVIFSGATEACLLSVMAYDRFQAMCHPLLYVVIINRRVCAGLVGASWAIGMGTGLINTLLLAQQHFCGPNVIHSFACELPPVLLLTCSDPCASIVSILTTMSVLGLGTLVLLLGSYSCIIMTALRINSATGRSKIFSTCSSHFLVVTIFYTSGVLRYMIPASGSALEQVLSVQYSVITPLLNPLIYSLKSQEVKVALRRMLARKSRLPL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more GPCR_Rhodpsn_7TM that are essential for its biological function; 2. The protein should belong to Olfact_rcpt, Olfact_rcpt, Olfact_rcpt, Olfact_rcpt, Olfact_rcpt, GPCR_Rhodpsn, GPCR_Rhodpsn, GPCR_Rhodpsn, GPCR_Rhodpsn, GPCR_Rhodpsn, Olfactory_GPCR, Olfact_rcpt that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MEVSNMTTVTVFILLGLSNNPQVQALLFVLFLVIYLLTLLGNLLMVLVISTDSHLCTPMYFFLRQLSFLDAFYSSIIVPKLLENLLSKGETISFLECFTQISLVIFSGATEACLLSVMAYDRFQAMCHPLLYVVIINRRVCAGLVGASWAIGMGTGLINTLLLAQQHFCGPNVIHSFACELPPVLLLTCSDPCASIVSILTTMSVLGLGTLVLLLGSYSCIIMTALRINSATGRSKIFSTCSSHFLVVTIFYTSGVLRYMIPASGSALEQVLSVQYSVITPLLNPLIYSLKSQEVKVALRRMLARKSRLPL" }, { "InterPro": [ { "InterPro-ID": "IPR048254", "InterPro-Name": "CDP_ALCOHOL_P_TRANSF_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 167, "End": 189 }, { "InterPro-ID": "IPR050324", "InterPro-Name": "CDP-alcohol_PTase-I", "InterPro-Type": "FAMILY", "Beg": 112, "End": 312 }, { "InterPro-ID": "IPR000462", "InterPro-Name": "CDP-OH_P_trans", "InterPro-Type": "FAMILY", "Beg": 125, "End": 239 }, { "InterPro-ID": "IPR043130", "InterPro-Name": "CDP-OH_PTrfase_TM_dom", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 117, "End": 266 } ], "response#1": "MASGQMAPSLLRRPITFVSSCPPALRSFGALCPPTGSTDLIGGTGRDILIAAAPARRAPLHATLPLLRSLHTSPAPQLSASHQHQAQQQQQQTKQPQQPYDPQQDQVPSTSTASSSKPAADPVYNLPNAVSVARLVSGPLIGYWLVQGHYEAATLALAVSGASDWLDGWLARRLGASSVFGSYLDPLADKVLIGCVAAALLMNGAMPGWVAGVVVGRDVLLVAGSFVFRLRGFGWRWPGAAAFFRTVDTSAAAAGAATGAANGVASGGGGGGEGVSFMRPLLISKANTVLQLLLLGGYLLRGMDGGAGLQLLLPGGGGEELIMGLELATAATTVASGLAYGTMAVQGKLFK", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to CDP-alcohol_PTase-I, CDP-OH_P_trans that shares evolutionary origin and functional similarity; 2. The protein should be classified within CDP-OH_PTrfase_TM_dom sharing conserved structural features; 3. The protein should contain CDP_ALCOHOL_P_TRANSF_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MASGQMAPSLLRRPITFVSSCPPALRSFGALCPPTGSTDLIGGTGRDILIAAAPARRAPLHATLPLLRSLHTSPAPQLSASHQHQAQQQQQQTKQPQQPYDPQQDQVPSTSTASSSKPAADPVYNLPNAVSVARLVSGPLIGYWLVQGHYEAATLALAVSGASDWLDGWLARRLGASSVFGSYLDPLADKVLIGCVAAALLMNGAMPGWVAGVVVGRDVLLVAGSFVFRLRGFGWRWPGAAAFFRTVDTSAAAAGAATGAANGVASGGGGGGEGVSFMRPLLISKANTVLQLLLLGGYLLRGMDGGAGLQLLLPGGGGEELIMGLELATAATTVASGLAYGTMAVQGKLFK" }, { "InterPro": [ { "InterPro-ID": "IPR002227", "InterPro-Name": "Tyrosinase_Cu-bd", "InterPro-Type": "DOMAIN", "Beg": 319, "End": 330 }, { "InterPro-ID": "IPR008922", "InterPro-Name": "Di-copper_centre_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1, "End": 416 }, { "InterPro-ID": "IPR050316", "InterPro-Name": "Tyrosinase/Hemocyanin", "InterPro-Type": "FAMILY", "Beg": 26, "End": 482 }, { "InterPro-ID": "IPR002227", "InterPro-Name": "Tyrosinase_Cu-bd", "InterPro-Type": "DOMAIN", "Beg": 47, "End": 339 }, { "InterPro-ID": "IPR002227", "InterPro-Name": "Tyrosinase_Cu-bd", "InterPro-Type": "DOMAIN", "Beg": 113, "End": 118 }, { "InterPro-ID": "IPR002227", "InterPro-Name": "Tyrosinase_Cu-bd", "InterPro-Type": "DOMAIN", "Beg": 318, "End": 336 }, { "InterPro-ID": "IPR002227", "InterPro-Name": "Tyrosinase_Cu-bd", "InterPro-Type": "DOMAIN", "Beg": 281, "End": 292 }, { "InterPro-ID": "IPR002227", "InterPro-Name": "Tyrosinase_Cu-bd", "InterPro-Type": "DOMAIN", "Beg": 84, "End": 101 }, { "InterPro-ID": "IPR008922", "InterPro-Name": "Di-copper_centre_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 6, "End": 409 } ], "response#1": "MGDSSELNVRRSVRDLQAEYDRGNRKPLEDLIRAWKGIQELPPDDKRSFFILGGYHGEPFDYRNAVDALPPDDIYTYWGGWCNHGNVLFPTWHRIYILKLEEALQSIVPGVTLPFWDETSEETVKKGIPDVLTREYFELDGENIKNPLYSYTLPLSLSDNVPGDNKAYEKPAGYETVRYPLSGLVGTPEARAATAKHNAKYPNPIENTQLLNKNIIAWLHGSGKDEEGPTTTDPNPKGRGVKWMYEKCLSAPNYTVFSNTTSAGQWNLDHPAKSVVALEQPHNDVHLAVGGFDIPGQGESGQVADANGDMGENNTAALDPIFFFHHCNVDRMFWLWQKQNGFINKLEVITGYYGTNSSDSQGPTPGIPPGTPLDLNTPLNPFIKDEFGNPFTSMDCINIEEQLGYTYGPGSLDEVPKPEPITGGSTKKLTVRGINRGLFDGSFVIRAYASVPDAQGQLTEYYLGDHAVLSRRNVVKCANCLTHLEVIAHFPLDTLSADLVDKAEYWITIQHRGHSKRMKVDKDTGQSEKALLAQRAELPEKLKYSISVTD", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Tyrosinase_Cu-bd, Tyrosinase_Cu-bd, Tyrosinase_Cu-bd, Tyrosinase_Cu-bd, Tyrosinase_Cu-bd, Tyrosinase_Cu-bd that are essential for its biological function; 2. The protein should belong to Tyrosinase/Hemocyanin that shares evolutionary origin and functional similarity; 3. The protein should be classified within Di-copper_centre_dom_sf, Di-copper_centre_dom_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MGDSSELNVRRSVRDLQAEYDRGNRKPLEDLIRAWKGIQELPPDDKRSFFILGGYHGEPFDYRNAVDALPPDDIYTYWGGWCNHGNVLFPTWHRIYILKLEEALQSIVPGVTLPFWDETSEETVKKGIPDVLTREYFELDGENIKNPLYSYTLPLSLSDNVPGDNKAYEKPAGYETVRYPLSGLVGTPEARAATAKHNAKYPNPIENTQLLNKNIIAWLHGSGKDEEGPTTTDPNPKGRGVKWMYEKCLSAPNYTVFSNTTSAGQWNLDHPAKSVVALEQPHNDVHLAVGGFDIPGQGESGQVADANGDMGENNTAALDPIFFFHHCNVDRMFWLWQKQNGFINKLEVITGYYGTNSSDSQGPTPGIPPGTPLDLNTPLNPFIKDEFGNPFTSMDCINIEEQLGYTYGPGSLDEVPKPEPITGGSTKKLTVRGINRGLFDGSFVIRAYASVPDAQGQLTEYYLGDHAVLSRRNVVKCANCLTHLEVIAHFPLDTLSADLVDKAEYWITIQHRGHSKRMKVDKDTGQSEKALLAQRAELPEKLKYSISVTD" }, { "InterPro": [ { "InterPro-ID": "IPR002347", "InterPro-Name": "SDR_fam", "InterPro-Type": "FAMILY", "Beg": 26, "End": 263 }, { "InterPro-ID": "IPR036291", "InterPro-Name": "NAD(P)-bd_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 18, "End": 265 }, { "InterPro-ID": "IPR002347", "InterPro-Name": "SDR_fam", "InterPro-Type": "FAMILY", "Beg": 146, "End": 162 }, { "InterPro-ID": "IPR002347", "InterPro-Name": "SDR_fam", "InterPro-Type": "FAMILY", "Beg": 194, "End": 211 }, { "InterPro-ID": "IPR002347", "InterPro-Name": "SDR_fam", "InterPro-Type": "FAMILY", "Beg": 174, "End": 193 }, { "InterPro-ID": "IPR002347", "InterPro-Name": "SDR_fam", "InterPro-Type": "FAMILY", "Beg": 99, "End": 110 }, { "InterPro-ID": "IPR002347", "InterPro-Name": "SDR_fam", "InterPro-Type": "FAMILY", "Beg": 21, "End": 38 }, { "InterPro-ID": "IPR002347", "InterPro-Name": "SDR_fam", "InterPro-Type": "FAMILY", "Beg": 227, "End": 247 } ], "response#1": "MPISIPKGEKLMDLLSMKGKVTIVTGASGPRGMGIEAARGIAEMGGNVALTYAGRKEGGEKNAAALEKEYGIKAKAYKLDVANYESCCQLVKDVIADFGQIDAFVANAGKTADSGVLDGEISAFEEVIQTDLLGVAYCAKAVGHHFKERQTGSFVITASMSGHIANFPQEQTSYNVAKAGCIHMARSLANEWRDFARVNSISPGYIDTGLSDFVDKETQKLWHSMIPMGRDGDAKELKAAYVYFCSDASTYTTGSDLVIDGGYCAR", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to SDR_fam, SDR_fam, SDR_fam, SDR_fam, SDR_fam, SDR_fam, SDR_fam that shares evolutionary origin and functional similarity; 2. The protein should be classified within NAD(P)-bd_dom_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MPISIPKGEKLMDLLSMKGKVTIVTGASGPRGMGIEAARGIAEMGGNVALTYAGRKEGGEKNAAALEKEYGIKAKAYKLDVANYESCCQLVKDVIADFGQIDAFVANAGKTADSGVLDGEISAFEEVIQTDLLGVAYCAKAVGHHFKERQTGSFVITASMSGHIANFPQEQTSYNVAKAGCIHMARSLANEWRDFARVNSISPGYIDTGLSDFVDKETQKLWHSMIPMGRDGDAKELKAAYVYFCSDASTYTTGSDLVIDGGYCAR" }, { "InterPro": [ { "InterPro-ID": "IPR014830", "InterPro-Name": "Glycolipid_transfer_prot_dom", "InterPro-Type": "DOMAIN", "Beg": 28, "End": 166 }, { "InterPro-ID": "IPR036497", "InterPro-Name": "GLTP_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 18, "End": 200 }, { "InterPro-ID": "IPR014830", "InterPro-Name": "Glycolipid_transfer_prot_dom", "InterPro-Type": "DOMAIN", "Beg": 7, "End": 193 }, { "InterPro-ID": "IPR036497", "InterPro-Name": "GLTP_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 7, "End": 201 } ], "response#1": "MAAFPPGGTFFDTLKRSFTDVPVESGKIATTQFLEACESLTTLFDVLGSTAFKPVKSDMTGNIKKIRDRQLAAPVDSETLQDLVRNELATKKHTATEGLVWLNRALDFTAQALRQNLTNSGEEVSVSFRSAYGNTLSKHHSFMIKPIFSAAMSATPYRKDFYAKLGDDQARVEKELGVWLSSLENIVKILNDFLASKEAKW", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Glycolipid_transfer_prot_dom, Glycolipid_transfer_prot_dom that are essential for its biological function; 2. The protein should be classified within GLTP_sf, GLTP_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MAAFPPGGTFFDTLKRSFTDVPVESGKIATTQFLEACESLTTLFDVLGSTAFKPVKSDMTGNIKKIRDRQLAAPVDSETLQDLVRNELATKKHTATEGLVWLNRALDFTAQALRQNLTNSGEEVSVSFRSAYGNTLSKHHSFMIKPIFSAAMSATPYRKDFYAKLGDDQARVEKELGVWLSSLENIVKILNDFLASKEAKW" }, { "InterPro": [ { "InterPro-ID": "IPR013131", "InterPro-Name": "Mannitol_DH_N", "InterPro-Type": "DOMAIN", "Beg": 4, "End": 195 }, { "InterPro-ID": "IPR013118", "InterPro-Name": "Mannitol_DH_C", "InterPro-Type": "DOMAIN", "Beg": 206, "End": 348 }, { "InterPro-ID": "IPR036291", "InterPro-Name": "NAD(P)-bd_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 3, "End": 204 }, { "InterPro-ID": "IPR013328", "InterPro-Name": "6PGD_dom2", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 209, "End": 386 }, { "InterPro-ID": "IPR023028", "InterPro-Name": "Mannitol_1_phos_5_DH", "InterPro-Type": "FAMILY", "Beg": 4, "End": 381 }, { "InterPro-ID": "IPR000669", "InterPro-Name": "Mannitol_DH", "InterPro-Type": "FAMILY", "Beg": 171, "End": 186 }, { "InterPro-ID": "IPR000669", "InterPro-Name": "Mannitol_DH", "InterPro-Type": "FAMILY", "Beg": 6, "End": 16 }, { "InterPro-ID": "IPR000669", "InterPro-Name": "Mannitol_DH", "InterPro-Type": "FAMILY", "Beg": 153, "End": 166 }, { "InterPro-ID": "IPR000669", "InterPro-Name": "Mannitol_DH", "InterPro-Type": "FAMILY", "Beg": 117, "End": 130 }, { "InterPro-ID": "IPR008927", "InterPro-Name": "6-PGluconate_DH-like_C_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 206, "End": 385 } ], "response#1": "MSDMKAIHFGGGNIGRGFVAEFLHKSGYEVVFVDVMDAIINALQQNKSYTVTEVGTSETKSKTIDNYRAINSKTDEDKVVEEIATADIVTCAVGPNILKFIAPVIAKGIENRKKDSPIAVIACENAIGATDTLRKFIEEKLSDSTKSNIQDKARFANSAIDRIVPMQDENAGLNVKIEKFYEWCVESKPFLPSQPPKIEGVHFVEDLTPFIERKLFTVNTGHATAAYYGYNRGKECIHDVLQDKELNEIVRNTLKETAHLIVNKHEISEEDQNQYVEKIIKRISNPVLKDNVERVGRAPLRKLSRNERFIGPAAHLAEMGAKYDALLGGIEMCLRFQNVEGDDESFELAKILKENSSSDATEKITGLERNHTLFPAVEEVVKKVQA", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Mannitol_DH_N, Mannitol_DH_C that are essential for its biological function; 2. The protein should belong to Mannitol_1_phos_5_DH, Mannitol_DH, Mannitol_DH, Mannitol_DH, Mannitol_DH that shares evolutionary origin and functional similarity; 3. The protein should be classified within NAD(P)-bd_dom_sf, 6PGD_dom2, 6-PGluconate_DH-like_C_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MSDMKAIHFGGGNIGRGFVAEFLHKSGYEVVFVDVMDAIINALQQNKSYTVTEVGTSETKSKTIDNYRAINSKTDEDKVVEEIATADIVTCAVGPNILKFIAPVIAKGIENRKKDSPIAVIACENAIGATDTLRKFIEEKLSDSTKSNIQDKARFANSAIDRIVPMQDENAGLNVKIEKFYEWCVESKPFLPSQPPKIEGVHFVEDLTPFIERKLFTVNTGHATAAYYGYNRGKECIHDVLQDKELNEIVRNTLKETAHLIVNKHEISEEDQNQYVEKIIKRISNPVLKDNVERVGRAPLRKLSRNERFIGPAAHLAEMGAKYDALLGGIEMCLRFQNVEGDDESFELAKILKENSSSDATEKITGLERNHTLFPAVEEVVKKVQA" }, { "InterPro": [ { "InterPro-ID": "IPR037143", "InterPro-Name": "4-PPantetheinyl_Trfase_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 11, "End": 155 }, { "InterPro-ID": "IPR037143", "InterPro-Name": "4-PPantetheinyl_Trfase_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 12, "End": 115 }, { "InterPro-ID": "IPR055066", "InterPro-Name": "AASDHPPT_N", "InterPro-Type": "DOMAIN", "Beg": 30, "End": 118 }, { "InterPro-ID": "IPR050559", "InterPro-Name": "P-Pant_transferase_sf", "InterPro-Type": "FAMILY", "Beg": 11, "End": 318 }, { "InterPro-ID": "IPR037143", "InterPro-Name": "4-PPantetheinyl_Trfase_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 223, "End": 313 } ], "response#1": "MTDSNLLGLTCWLIDTRTLWPGQHIKDAASDILHLLSNDERNAVLRKIFIADARMSLASALLKRLYISRALNIPWRDVKIARKGDPTHGKPCAVLPDGSFAPIDFNVSHQAGLVSLVGWNPPPGQSQSALVGTDIVCVNERDDYRTIDQEGFDAWIDIYEDVFSEAERWDMKYNVDYITLLDGRIIQGNSLGRVDRCVRRNKDLSITLPTGETHSFNSDLLIDAKLRRFYSFFCYKEAYIKLAGEALLAPWLKELEFQNVKSPKPGTVARCSTHGTWGEKVSDVEVVLHGEKVEDVKMTLQAFEENFMLATAVQGLRDLEAPPFTKLNLENDVVAFAS", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more AASDHPPT_N that are essential for its biological function; 2. The protein should belong to P-Pant_transferase_sf that shares evolutionary origin and functional similarity; 3. The protein should be classified within 4-PPantetheinyl_Trfase_dom_sf, 4-PPantetheinyl_Trfase_dom_sf, 4-PPantetheinyl_Trfase_dom_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MTDSNLLGLTCWLIDTRTLWPGQHIKDAASDILHLLSNDERNAVLRKIFIADARMSLASALLKRLYISRALNIPWRDVKIARKGDPTHGKPCAVLPDGSFAPIDFNVSHQAGLVSLVGWNPPPGQSQSALVGTDIVCVNERDDYRTIDQEGFDAWIDIYEDVFSEAERWDMKYNVDYITLLDGRIIQGNSLGRVDRCVRRNKDLSITLPTGETHSFNSDLLIDAKLRRFYSFFCYKEAYIKLAGEALLAPWLKELEFQNVKSPKPGTVARCSTHGTWGEKVSDVEVVLHGEKVEDVKMTLQAFEENFMLATAVQGLRDLEAPPFTKLNLENDVVAFAS" }, { "InterPro": [ { "InterPro-ID": "IPR001647", "InterPro-Name": "HTH_TetR", "InterPro-Type": "DOMAIN", "Beg": 21, "End": 81 }, { "InterPro-ID": "IPR050109", "InterPro-Name": "HTH-type_TetR-like_transc_reg", "InterPro-Type": "FAMILY", "Beg": 10, "End": 206 }, { "InterPro-ID": "IPR001647", "InterPro-Name": "HTH_TetR", "InterPro-Type": "DOMAIN", "Beg": 27, "End": 40 }, { "InterPro-ID": "IPR001647", "InterPro-Name": "HTH_TetR", "InterPro-Type": "DOMAIN", "Beg": 48, "End": 71 }, { "InterPro-ID": "IPR011075", "InterPro-Name": "TetR_C", "InterPro-Type": "DOMAIN", "Beg": 113, "End": 199 }, { "InterPro-ID": "IPR001647", "InterPro-Name": "HTH_TetR", "InterPro-Type": "DOMAIN", "Beg": 27, "End": 73 }, { "InterPro-ID": "IPR036271", "InterPro-Name": "Tet_transcr_reg_TetR-rel_C_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 96, "End": 202 }, { "InterPro-ID": "IPR009057", "InterPro-Name": "Homeodomain-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 18, "End": 83 } ], "response#1": "MTRTARAKSAPAVGPGRPRDTDLDTAIIHATRQRLAEQGYSQISLSEIAAAAGTTRPSLYRRWPTKLDLVVAALEWGFRAQTDSYPTEAISELEPREAFIEAIRRLDPAYFNADAMLLMGNFMGEARRTPELLDVVRERAVNPRLAQLEAVLLKLREDGRIRADTDVRTVATLCFGAYFATFLREDADHRAIAERVCDTLWPSMVADG", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more HTH_TetR, HTH_TetR, HTH_TetR, TetR_C, HTH_TetR that are essential for its biological function; 2. The protein should belong to HTH-type_TetR-like_transc_reg that shares evolutionary origin and functional similarity; 3. The protein should be classified within Tet_transcr_reg_TetR-rel_C_sf, Homeodomain-like_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MTRTARAKSAPAVGPGRPRDTDLDTAIIHATRQRLAEQGYSQISLSEIAAAAGTTRPSLYRRWPTKLDLVVAALEWGFRAQTDSYPTEAISELEPREAFIEAIRRLDPAYFNADAMLLMGNFMGEARRTPELLDVVRERAVNPRLAQLEAVLLKLREDGRIRADTDVRTVATLCFGAYFATFLREDADHRAIAERVCDTLWPSMVADG" }, { "InterPro": [ { "InterPro-ID": "IPR000415", "InterPro-Name": "Nitroreductase-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 22, "End": 241 }, { "InterPro-ID": "IPR000415", "InterPro-Name": "Nitroreductase-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 16, "End": 238 }, { "InterPro-ID": "IPR029479", "InterPro-Name": "Nitroreductase", "InterPro-Type": "DOMAIN", "Beg": 26, "End": 218 } ], "response#1": "MSSTAPEDVARPLLALPAIEAFDAIVRGRRSVRSYADVQVPRRTVRDVLELAARAPSNSNVQPWHTYVLTGRHKRALTDSVLRYYDTIGRTVREFDYQPGPDGWEEPYKERRESFGEGLYGRALGLSLADVDDREFYHRRNYDFFAAPVGLIVTVARNPRLSALIDAGAYIQTILLSARSRGLSTCAQASFLDFHPAVRECLAIPTHRTIVCGISLGYEDAQHPIASNATTREPVDRHVTFLWDDDD", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Nitroreductase that are essential for its biological function; 2. The protein should be classified within Nitroreductase-like, Nitroreductase-like sharing conserved structural features. The designed protein sequence is ", "reference": "MSSTAPEDVARPLLALPAIEAFDAIVRGRRSVRSYADVQVPRRTVRDVLELAARAPSNSNVQPWHTYVLTGRHKRALTDSVLRYYDTIGRTVREFDYQPGPDGWEEPYKERRESFGEGLYGRALGLSLADVDDREFYHRRNYDFFAAPVGLIVTVARNPRLSALIDAGAYIQTILLSARSRGLSTCAQASFLDFHPAVRECLAIPTHRTIVCGISLGYEDAQHPIASNATTREPVDRHVTFLWDDDD" }, { "InterPro": [ { "InterPro-ID": "IPR029058", "InterPro-Name": "AB_hydrolase_fold", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1, "End": 270 }, { "InterPro-ID": "IPR029058", "InterPro-Name": "AB_hydrolase_fold", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 10, "End": 264 }, { "InterPro-ID": "IPR000073", "InterPro-Name": "AB_hydrolase_1", "InterPro-Type": "DOMAIN", "Beg": 20, "End": 257 } ], "response#1": "MGIVEEAHNVKILGSGEQTVVLAHGFGTDQSVWKHLVPHLVDDYKVVIFDNMGAGTTNPDYFDFERYSTLEGYAYDVIAILEEFQVGSCIYVGHSVSAMIGVIASIARPDLFTKLVTVSASPRYLNDMDYYGGFEQEDLDQLYEAMRSNYKAWCSGFAPLVIGGDMDSVAIQEFSRTLFNMRPDIALSVLQMIFQSDLRHLLPHVSVPCHIIQSMKDLAVPVVVSEYLHQNLGGGSIVEVMSTEGHLPQLSSPDVVIPVLLRHIHHDIAI", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more AB_hydrolase_1 that are essential for its biological function; 2. The protein should be classified within AB_hydrolase_fold, AB_hydrolase_fold sharing conserved structural features. The designed protein sequence is ", "reference": "MGIVEEAHNVKILGSGEQTVVLAHGFGTDQSVWKHLVPHLVDDYKVVIFDNMGAGTTNPDYFDFERYSTLEGYAYDVIAILEEFQVGSCIYVGHSVSAMIGVIASIARPDLFTKLVTVSASPRYLNDMDYYGGFEQEDLDQLYEAMRSNYKAWCSGFAPLVIGGDMDSVAIQEFSRTLFNMRPDIALSVLQMIFQSDLRHLLPHVSVPCHIIQSMKDLAVPVVVSEYLHQNLGGGSIVEVMSTEGHLPQLSSPDVVIPVLLRHIHHDIAI" }, { "InterPro": [ { "InterPro-ID": "IPR047817", "InterPro-Name": "ABC2_TM_bact-type", "InterPro-Type": "DOMAIN", "Beg": 53, "End": 280 }, { "InterPro-ID": "IPR013525", "InterPro-Name": "ABC2_TM", "InterPro-Type": "DOMAIN", "Beg": 38, "End": 246 }, { "InterPro-ID": "IPR000412", "InterPro-Name": "ABC_2_transport", "InterPro-Type": "FAMILY", "Beg": 10, "End": 282 }, { "InterPro-ID": "IPR051328", "InterPro-Name": "T7SS_ABC-Transporter", "InterPro-Type": "FAMILY", "Beg": 80, "End": 280 } ], "response#1": "MTTSPGTVESTTPVSGQLRTVLSAGERPARATAVSATLTHLWRAMMAFKHFPVQLIDIVLMPLIFLLMFTYLFGGAFADSTEEYLQFYLPGVTVQAVVMMTVYTGTSLNTDIHKGVFDRFRTLPFWQPATLAGSLLGDVLRYVVALATTVFLGLLLGFRADGGFLGVVGAMLVLIVFGFSVSWIFAALGVVASEPERVSGTSMIVLYPLLFMSNIFVMPETMPGWMQAIVDANPMSHAATASRELMHGTAGFWDVGLVLCVSAGLVAVFAPLTMRLYRNKNAH", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more ABC2_TM_bact-type, ABC2_TM that are essential for its biological function; 2. The protein should belong to ABC_2_transport, T7SS_ABC-Transporter that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MTTSPGTVESTTPVSGQLRTVLSAGERPARATAVSATLTHLWRAMMAFKHFPVQLIDIVLMPLIFLLMFTYLFGGAFADSTEEYLQFYLPGVTVQAVVMMTVYTGTSLNTDIHKGVFDRFRTLPFWQPATLAGSLLGDVLRYVVALATTVFLGLLLGFRADGGFLGVVGAMLVLIVFGFSVSWIFAALGVVASEPERVSGTSMIVLYPLLFMSNIFVMPETMPGWMQAIVDANPMSHAATASRELMHGTAGFWDVGLVLCVSAGLVAVFAPLTMRLYRNKNAH" }, { "InterPro": [ { "InterPro-ID": "IPR000412", "InterPro-Name": "ABC_2_transport", "InterPro-Type": "FAMILY", "Beg": 2, "End": 272 }, { "InterPro-ID": "IPR047817", "InterPro-Name": "ABC2_TM_bact-type", "InterPro-Type": "DOMAIN", "Beg": 38, "End": 270 }, { "InterPro-ID": "IPR013525", "InterPro-Name": "ABC2_TM", "InterPro-Type": "DOMAIN", "Beg": 22, "End": 228 }, { "InterPro-ID": "IPR051328", "InterPro-Name": "T7SS_ABC-Transporter", "InterPro-Type": "FAMILY", "Beg": 63, "End": 270 } ], "response#1": "MTTLDLTARSDRGRVYWLLADCWNIVRRGLTHYQRQPVNIAWQLGFPILSVLLYGYVFGSAMKVPGGGDYKDFLMPGMFVMTMAFGFINTATLVVYDSTKGVIDRFRSMPMASSAVVAGRGVTDLITACAELAIMMLTAFAMGWRPDGGLGFLGAFGLLLWLRFALIWIGVWLGLLVPNPEAAGGLFAVAFPLTMISSIMVAPQLMPDWLGWVAMWNPISSTAAATRELFGTPVGGDTWVEQHALLMAGVWPVILTLVFLPLAVRRFKKLSR", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more ABC2_TM_bact-type, ABC2_TM that are essential for its biological function; 2. The protein should belong to ABC_2_transport, T7SS_ABC-Transporter that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MTTLDLTARSDRGRVYWLLADCWNIVRRGLTHYQRQPVNIAWQLGFPILSVLLYGYVFGSAMKVPGGGDYKDFLMPGMFVMTMAFGFINTATLVVYDSTKGVIDRFRSMPMASSAVVAGRGVTDLITACAELAIMMLTAFAMGWRPDGGLGFLGAFGLLLWLRFALIWIGVWLGLLVPNPEAAGGLFAVAFPLTMISSIMVAPQLMPDWLGWVAMWNPISSTAAATRELFGTPVGGDTWVEQHALLMAGVWPVILTLVFLPLAVRRFKKLSR" }, { "InterPro": [ { "InterPro-ID": "IPR047817", "InterPro-Name": "ABC2_TM_bact-type", "InterPro-Type": "DOMAIN", "Beg": 25, "End": 251 }, { "InterPro-ID": "IPR051784", "InterPro-Name": "Nod_factor_ABC_transporter", "InterPro-Type": "FAMILY", "Beg": 6, "End": 250 }, { "InterPro-ID": "IPR013525", "InterPro-Name": "ABC2_TM", "InterPro-Type": "DOMAIN", "Beg": 10, "End": 215 }, { "InterPro-ID": "IPR000412", "InterPro-Name": "ABC_2_transport", "InterPro-Type": "FAMILY", "Beg": 1, "End": 253 } ], "response#1": "MTAYALTDSWTMTRRELARWARQPVQLVVNLVFPVMLLLMFGYLIGGGRGVNGEYRDYLIPGMLALTMAFGLEGTMIAVTRDLDKGVIDRFRSMPMADGAVLVGRSAADMLQSAMALVVLIGVGAALGWRVHGGPVAFLGAVGLLLLFRFAMLWIGIYLALVAGKPEMVQAVQILVWPIGFLSNALALPDTMPGWLGTVVEWNPMSHTATAVRDLFGTPGAESGHVGAALVWPLALLAVFFPLAVRRFGRLSR", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more ABC2_TM_bact-type, ABC2_TM that are essential for its biological function; 2. The protein should belong to Nod_factor_ABC_transporter, ABC_2_transport that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MTAYALTDSWTMTRRELARWARQPVQLVVNLVFPVMLLLMFGYLIGGGRGVNGEYRDYLIPGMLALTMAFGLEGTMIAVTRDLDKGVIDRFRSMPMADGAVLVGRSAADMLQSAMALVVLIGVGAALGWRVHGGPVAFLGAVGLLLLFRFAMLWIGIYLALVAGKPEMVQAVQILVWPIGFLSNALALPDTMPGWLGTVVEWNPMSHTATAVRDLFGTPGAESGHVGAALVWPLALLAVFFPLAVRRFGRLSR" }, { "InterPro": [ { "InterPro-ID": "IPR042099", "InterPro-Name": "ANL_N_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 189, "End": 618 }, { "InterPro-ID": "IPR010071", "InterPro-Name": "AA_adenyl_dom", "InterPro-Type": "DOMAIN", "Beg": 241, "End": 641 }, { "InterPro-ID": "IPR023213", "InterPro-Name": "CAT-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 865, "End": 1038 }, { "InterPro-ID": "IPR000873", "InterPro-Name": "AMP-dep_synth/lig_dom", "InterPro-Type": "DOMAIN", "Beg": 222, "End": 567 }, { "InterPro-ID": "IPR006162", "InterPro-Name": "Ppantetheine_attach_site", "InterPro-Type": "PTM", "Beg": 791, "End": 806 }, { "InterPro-ID": "IPR009081", "InterPro-Name": "PP-bd_ACP", "InterPro-Type": "DOMAIN", "Beg": 759, "End": 836 }, { "InterPro-ID": "IPR036736", "InterPro-Name": "ACP-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 759, "End": 832 }, { "InterPro-ID": "IPR045851", "InterPro-Name": "AMP-bd_C_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 619, "End": 745 }, { "InterPro-ID": "IPR001242", "InterPro-Name": "Condensatn", "InterPro-Type": "DOMAIN", "Beg": 872, "End": 1286 }, { "InterPro-ID": "IPR020845", "InterPro-Name": "AMP-binding_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 369, "End": 380 }, { "InterPro-ID": "IPR036736", "InterPro-Name": "ACP-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 758, "End": 831 }, { "InterPro-ID": "IPR020806", "InterPro-Name": "PKS_PP-bd", "InterPro-Type": "DOMAIN", "Beg": 765, "End": 836 }, { "InterPro-ID": "IPR009081", "InterPro-Name": "PP-bd_ACP", "InterPro-Type": "DOMAIN", "Beg": 768, "End": 831 } ], "response#1": "MDLTTTSHARVDSGGVPFTSSLNDPTPPKLSASIALPAHLHLLAKAYGIPESHILQLAWALAANEQNARTAQWEHLELDERQAISWVLRHWQDPSVHRYLSPDELRGDKHQIPATVMAVVEEYSLFQTLALTGSETEIGMCFHPSTEQPWLRVIWNPEGMLASSASRLTRALESALHAVFLTPHVKVGDLTLFSIWDHQQILQWNSHYPQATDRLVHELFKDVVDASPQANAVAAWDGELTYRELDRLSSRLSGRLQDEFGVQPETIVVLCFEKSVWAIVAMLAVVKAGGAFLHVDPQHPAVRHQAMVQTTAAKLVLCSARTRSIISASVPECTSLVIDRRAFSVEPDHVQHETLLSSQNLSPRNAAYVVCTSGSTGTPKAIVVEHASLSTSVDAQANAMEISSGSRVLQYAAYTFDVSVGDIFTALTHGACICIPSDWERSHDLAGAINRLNVNQACLTSTVASILSPAEVPGLEKLTLGGEPATRQCVDAWAEQVRLKNVYGPAECTVWCMIQPEVSRHISVSNIGHGIGARAWIVHPEDHDRLMPVGAVGELLIEGPLVARGYLNDSTRTDEVFLSQPPRWLESFGPTPSRSRFYKTGDLARYGPAGALLFEGRKDTQIKLRGQRIELSEIEYRLHRALSDQVATAVELAHPKGSTAPVLAAFITWDQGIDLQNVQNVTLDARQEFEELASRIKAEIEQALPSYMVPALFIPVQTLPLTTSGKLDRKSLRHFCSQCSHEFLKKLDDSSPADAAPKESANPAEENLARLWAQVLERKSESIRRGDNFLSLGGDSLAAMRLVNLAARDLRLTLTVADVFNSPILADQANLLRPLVQTKHIAPFELVTDGDLPIQDLMDSVAKQCGLTSDQVEDVYPCTPYQEEMVRDSLSGTRTQMGQEVIQLASDLDLSRYLSACARVFQRCPILRTRFVEISGKLLQVVIREDISWQRPTSLAAYIEADNQTPPTLGKPLARWALTEDSTHLVLTMHHAIFDGISLGQIFGAIYAVYQSIPLPQVNLTFATFIGKIYRPHHDLPDASKQFWRSYLSPTAGSNDAPLSDVERASRPCANSGTQRLVTFQAGAVKALQQHGLTEATLARAAWACTLARGRQSPDSDVIFGTILTGRNIHLPGVDALAAPALAHTPIRVRMAAAQQEKPAHFLARVQADATAMIPFEHDGMDRIRALDEQVRVACDNMRTLLVIQPIPEGLILDSKSPFPGTMLSGPRVEAREMRHFHWYGLLMECTLLPMDGFFVRMSFDDTLYSPEAAERLLDEYSQTLHELAHGLTVDGSTE", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more AA_adenyl_dom, AMP-dep_synth/lig_dom, PP-bd_ACP, Condensatn, PKS_PP-bd, PP-bd_ACP that are essential for its biological function; 2. The protein should be classified within ANL_N_sf, CAT-like_dom_sf, ACP-like_sf, AMP-bd_C_sf, ACP-like_sf sharing conserved structural features; 3. The protein should contain AMP-binding_CS that is preserved across related proteins; 4. The protein should contain Ppantetheine_attach_site that allow regulation through chemical modifications. The designed protein sequence is ", "reference": "MDLTTTSHARVDSGGVPFTSSLNDPTPPKLSASIALPAHLHLLAKAYGIPESHILQLAWALAANEQNARTAQWEHLELDERQAISWVLRHWQDPSVHRYLSPDELRGDKHQIPATVMAVVEEYSLFQTLALTGSETEIGMCFHPSTEQPWLRVIWNPEGMLASSASRLTRALESALHAVFLTPHVKVGDLTLFSIWDHQQILQWNSHYPQATDRLVHELFKDVVDASPQANAVAAWDGELTYRELDRLSSRLSGRLQDEFGVQPETIVVLCFEKSVWAIVAMLAVVKAGGAFLHVDPQHPAVRHQAMVQTTAAKLVLCSARTRSIISASVPECTSLVIDRRAFSVEPDHVQHETLLSSQNLSPRNAAYVVCTSGSTGTPKAIVVEHASLSTSVDAQANAMEISSGSRVLQYAAYTFDVSVGDIFTALTHGACICIPSDWERSHDLAGAINRLNVNQACLTSTVASILSPAEVPGLEKLTLGGEPATRQCVDAWAEQVRLKNVYGPAECTVWCMIQPEVSRHISVSNIGHGIGARAWIVHPEDHDRLMPVGAVGELLIEGPLVARGYLNDSTRTDEVFLSQPPRWLESFGPTPSRSRFYKTGDLARYGPAGALLFEGRKDTQIKLRGQRIELSEIEYRLHRALSDQVATAVELAHPKGSTAPVLAAFITWDQGIDLQNVQNVTLDARQEFEELASRIKAEIEQALPSYMVPALFIPVQTLPLTTSGKLDRKSLRHFCSQCSHEFLKKLDDSSPADAAPKESANPAEENLARLWAQVLERKSESIRRGDNFLSLGGDSLAAMRLVNLAARDLRLTLTVADVFNSPILADQANLLRPLVQTKHIAPFELVTDGDLPIQDLMDSVAKQCGLTSDQVEDVYPCTPYQEEMVRDSLSGTRTQMGQEVIQLASDLDLSRYLSACARVFQRCPILRTRFVEISGKLLQVVIREDISWQRPTSLAAYIEADNQTPPTLGKPLARWALTEDSTHLVLTMHHAIFDGISLGQIFGAIYAVYQSIPLPQVNLTFATFIGKIYRPHHDLPDASKQFWRSYLSPTAGSNDAPLSDVERASRPCANSGTQRLVTFQAGAVKALQQHGLTEATLARAAWACTLARGRQSPDSDVIFGTILTGRNIHLPGVDALAAPALAHTPIRVRMAAAQQEKPAHFLARVQADATAMIPFEHDGMDRIRALDEQVRVACDNMRTLLVIQPIPEGLILDSKSPFPGTMLSGPRVEAREMRHFHWYGLLMECTLLPMDGFFVRMSFDDTLYSPEAAERLLDEYSQTLHELAHGLTVDGSTE" }, { "InterPro": [ { "InterPro-ID": "IPR017996", "InterPro-Name": "Royal_jelly/protein_yellow", "InterPro-Type": "FAMILY", "Beg": 37, "End": 390 }, { "InterPro-ID": "IPR017996", "InterPro-Name": "Royal_jelly/protein_yellow", "InterPro-Type": "FAMILY", "Beg": 104, "End": 390 }, { "InterPro-ID": "IPR011042", "InterPro-Name": "6-blade_b-propeller_TolB-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 21, "End": 394 } ], "response#1": "MKLILTVLAFLSLQVALSDDVGRLYEWSKIDIVGVRPSVYDSSNIIPTGVAYDADSKMLFFGLPRKYSKVPITVAQLSTRSYNSAERRDPPLDKFSGKSKKPLTSVYQPVIDDCRRLWVLDVGIVEVKAERKTYPTKNPALVAFDLTKPDYPEIHRYELTGDAAKTPLGYGGFAVDVVNPKKCGKNDEKTYVYIANFVENSLIVYDKKKSDAWVLKDDSFKPEGVSTYTHNGKEHELKTGIFGIALGDRNKEGNRPAYYLAGSSTKLYRLDTKLLKKKGSKLVPKLIGDRGYKTEAIALAYDPETKVLFFAETDSRQVSCWNIKKELKPENVGVIYSSAKLNFATDMMVDSKGFLWFMSNGQPPFDEKMKYEDPHIRLMKVKTKKAIKGEKRCQG", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Royal_jelly/protein_yellow, Royal_jelly/protein_yellow that shares evolutionary origin and functional similarity; 2. The protein should be classified within 6-blade_b-propeller_TolB-like sharing conserved structural features. The designed protein sequence is ", "reference": "MKLILTVLAFLSLQVALSDDVGRLYEWSKIDIVGVRPSVYDSSNIIPTGVAYDADSKMLFFGLPRKYSKVPITVAQLSTRSYNSAERRDPPLDKFSGKSKKPLTSVYQPVIDDCRRLWVLDVGIVEVKAERKTYPTKNPALVAFDLTKPDYPEIHRYELTGDAAKTPLGYGGFAVDVVNPKKCGKNDEKTYVYIANFVENSLIVYDKKKSDAWVLKDDSFKPEGVSTYTHNGKEHELKTGIFGIALGDRNKEGNRPAYYLAGSSTKLYRLDTKLLKKKGSKLVPKLIGDRGYKTEAIALAYDPETKVLFFAETDSRQVSCWNIKKELKPENVGVIYSSAKLNFATDMMVDSKGFLWFMSNGQPPFDEKMKYEDPHIRLMKVKTKKAIKGEKRCQG" }, { "InterPro": [ { "InterPro-ID": "IPR016170", "InterPro-Name": "Cytok_DH_C_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 229, "End": 491 }, { "InterPro-ID": "IPR016164", "InterPro-Name": "FAD-linked_Oxase-like_C", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 221, "End": 530 }, { "InterPro-ID": "IPR006094", "InterPro-Name": "Oxid_FAD_bind_N", "InterPro-Type": "DOMAIN", "Beg": 45, "End": 182 }, { "InterPro-ID": "IPR016169", "InterPro-Name": "FAD-bd_PCMH_sub2", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 100, "End": 227 }, { "InterPro-ID": "IPR036318", "InterPro-Name": "FAD-bd_PCMH-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 5, "End": 227 }, { "InterPro-ID": "IPR016166", "InterPro-Name": "FAD-bd_PCMH", "InterPro-Type": "DOMAIN", "Beg": 39, "End": 226 }, { "InterPro-ID": "IPR016167", "InterPro-Name": "FAD-bd_PCMH_sub1", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1, "End": 99 } ], "response#1": "MNTQPLERALAAFREVLGTAHVSTDESARAAAETATFATTHRIPAIISPGSAAEVEACVRIAREHGVPLYPVSTGKNWGYGSRVPTSDGAIVLSLARMNRILDFNEELAYVAIEPGVTMRQLVAYLNDRGSRLMLSVTGSTPDSSVVGNICDRGFGAGVNAERIAHICNIEVVLPNGERLNTGFGRFPGAQTASIHRWGIGPQLDGLFTQSNLGIVTRMTIWLAPRPRHHEIFYFRLRDERRVEAVTDIIRDLKLQGLPRASVSLWNDYKLVSMKGQYPWQEAAGKTPLPEALLAKLRRAWGGAAWLGGGAILAASQDQIAAERAVIRKALHPHVDKLSFVGQRAARVARLLQRPVQRLTGFDLSEVVRAYEQSPHLGIPMERNIRSAYWRKKAPPPEQTDPDRDRCGAIWLAPAVPSTGKHVGTALRIVRERALAHAFEPGISVIFATERCANIVVALMYDRELPGEDGRAMACYQDIFDRLAAQGYLPYRLGIQSQSALPAAQSSYGTVVGALKRALDPDDILAPGRYDFRHEWPPADN", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Oxid_FAD_bind_N, FAD-bd_PCMH that are essential for its biological function; 2. The protein should be classified within Cytok_DH_C_sf, FAD-linked_Oxase-like_C, FAD-bd_PCMH_sub2, FAD-bd_PCMH-like_sf, FAD-bd_PCMH_sub1 sharing conserved structural features. The designed protein sequence is ", "reference": "MNTQPLERALAAFREVLGTAHVSTDESARAAAETATFATTHRIPAIISPGSAAEVEACVRIAREHGVPLYPVSTGKNWGYGSRVPTSDGAIVLSLARMNRILDFNEELAYVAIEPGVTMRQLVAYLNDRGSRLMLSVTGSTPDSSVVGNICDRGFGAGVNAERIAHICNIEVVLPNGERLNTGFGRFPGAQTASIHRWGIGPQLDGLFTQSNLGIVTRMTIWLAPRPRHHEIFYFRLRDERRVEAVTDIIRDLKLQGLPRASVSLWNDYKLVSMKGQYPWQEAAGKTPLPEALLAKLRRAWGGAAWLGGGAILAASQDQIAAERAVIRKALHPHVDKLSFVGQRAARVARLLQRPVQRLTGFDLSEVVRAYEQSPHLGIPMERNIRSAYWRKKAPPPEQTDPDRDRCGAIWLAPAVPSTGKHVGTALRIVRERALAHAFEPGISVIFATERCANIVVALMYDRELPGEDGRAMACYQDIFDRLAAQGYLPYRLGIQSQSALPAAQSSYGTVVGALKRALDPDDILAPGRYDFRHEWPPADN" }, { "InterPro": [ { "InterPro-ID": "IPR052203", "InterPro-Name": "GHMP_Kinase-Related", "InterPro-Type": "FAMILY", "Beg": 24, "End": 948 }, { "InterPro-ID": "IPR006204", "InterPro-Name": "GHMP_kinase_N_dom", "InterPro-Type": "DOMAIN", "Beg": 692, "End": 768 }, { "InterPro-ID": "IPR036554", "InterPro-Name": "GHMP_kinase_C_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 795, "End": 925 }, { "InterPro-ID": "IPR020568", "InterPro-Name": "Ribosomal_Su5_D2-typ_SF", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 583, "End": 776 }, { "InterPro-ID": "IPR001174", "InterPro-Name": "HddA/FKP", "InterPro-Type": "FAMILY", "Beg": 589, "End": 604 }, { "InterPro-ID": "IPR001174", "InterPro-Name": "HddA/FKP", "InterPro-Type": "FAMILY", "Beg": 888, "End": 907 }, { "InterPro-ID": "IPR013750", "InterPro-Name": "GHMP_kinase_C_dom", "InterPro-Type": "DOMAIN", "Beg": 846, "End": 927 }, { "InterPro-ID": "IPR012887", "InterPro-Name": "GDP_fucose_pyrophosphorylase", "InterPro-Type": "DOMAIN", "Beg": 64, "End": 429 } ], "response#1": "MQKLLSLPSNLVQSFHELERVNRTDWFCTSDPVGKKLGSGGGTSWLLEECYNEYSDGATFGEWLEKEKRILLHAGGQSRRLPGYAPSGKILTPVPVFRWERGQHLGQNLLSLQLPLYEKIMSLAPDKLHTLIASGDVYIRSEKPLQSIPEADVVCYGLWVDPSLATHHGVFASDRKHPEQLDFMLQKPSLAELESLSKTHLFLMDIGIWLLSDRAVEILMKRSHKESSEELKYYDLYSDFGLALGTHPRIEDEEVNTLSVAILPLPGGEFYHYGTSKELISSTLSVQNKVYDQRRIMHRKVKPNPAMFVQNAVVRIPLCAENADLWIENSHIGPKWKIASRHIITGVPENDWSLAVPAGVCVDVVPMGDKGFVARPYGLDDVFKGDLRDSKTTLTGIPFGEWMSKRGLSYTDLKGRTDDLQAVSVFPMVNSVEELGLVLRWMLSEPELEEGKNIWLRSEHFSADEISAGANLKRLYAQREEFRKGNWKALAVNHEKSVFYQLDLADAAEDFVRLGLDMPELLPEDALQMSRIHNRMLRARILKLDGKDYRPEEQAAFDLLRDGLLDGISNRKSTPKLDVYSDQIVWGRSPVRIDMAGGWTDTPPYSLYSGGNVVNLAIELNGQPPLQVYVKPCKDFHIVLRSIDMGAMEIVSTFDELQDYKKIGSPFSIPKAALSLAGFAPAFSAVSYASLEEQLKDFGAGIEVTLLAAIPAGSGLGTSSILASTVLGAINDFCGLAWDKNEICQRTLVLEQLLTTGGGWQDQYGGVLQGVKLLQTEAGFAQSPLVRWLPDHLFTHPEYKDCHLLYYTGITRTAKGILAEIVSSMFLNSSLHLNLLSEMKAHALDMNEAIQRGSFVEFGRLVGKTWEQNKALDSGTNPPAVEAIIDLIKDYTLGYKLPGAGGGGYLYMVAKDPQAAVRIRKILTENAPNPRARFVEMTLSDKGFQVSRS", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more GHMP_kinase_N_dom, GHMP_kinase_C_dom, GDP_fucose_pyrophosphorylase that are essential for its biological function; 2. The protein should belong to GHMP_Kinase-Related, HddA/FKP, HddA/FKP that shares evolutionary origin and functional similarity; 3. The protein should be classified within GHMP_kinase_C_sf, Ribosomal_Su5_D2-typ_SF sharing conserved structural features. The designed protein sequence is ", "reference": "MQKLLSLPSNLVQSFHELERVNRTDWFCTSDPVGKKLGSGGGTSWLLEECYNEYSDGATFGEWLEKEKRILLHAGGQSRRLPGYAPSGKILTPVPVFRWERGQHLGQNLLSLQLPLYEKIMSLAPDKLHTLIASGDVYIRSEKPLQSIPEADVVCYGLWVDPSLATHHGVFASDRKHPEQLDFMLQKPSLAELESLSKTHLFLMDIGIWLLSDRAVEILMKRSHKESSEELKYYDLYSDFGLALGTHPRIEDEEVNTLSVAILPLPGGEFYHYGTSKELISSTLSVQNKVYDQRRIMHRKVKPNPAMFVQNAVVRIPLCAENADLWIENSHIGPKWKIASRHIITGVPENDWSLAVPAGVCVDVVPMGDKGFVARPYGLDDVFKGDLRDSKTTLTGIPFGEWMSKRGLSYTDLKGRTDDLQAVSVFPMVNSVEELGLVLRWMLSEPELEEGKNIWLRSEHFSADEISAGANLKRLYAQREEFRKGNWKALAVNHEKSVFYQLDLADAAEDFVRLGLDMPELLPEDALQMSRIHNRMLRARILKLDGKDYRPEEQAAFDLLRDGLLDGISNRKSTPKLDVYSDQIVWGRSPVRIDMAGGWTDTPPYSLYSGGNVVNLAIELNGQPPLQVYVKPCKDFHIVLRSIDMGAMEIVSTFDELQDYKKIGSPFSIPKAALSLAGFAPAFSAVSYASLEEQLKDFGAGIEVTLLAAIPAGSGLGTSSILASTVLGAINDFCGLAWDKNEICQRTLVLEQLLTTGGGWQDQYGGVLQGVKLLQTEAGFAQSPLVRWLPDHLFTHPEYKDCHLLYYTGITRTAKGILAEIVSSMFLNSSLHLNLLSEMKAHALDMNEAIQRGSFVEFGRLVGKTWEQNKALDSGTNPPAVEAIIDLIKDYTLGYKLPGAGGGGYLYMVAKDPQAAVRIRKILTENAPNPRARFVEMTLSDKGFQVSRS" }, { "InterPro": [ { "InterPro-ID": "IPR001736", "InterPro-Name": "PLipase_D/transphosphatidylase", "InterPro-Type": "DOMAIN", "Beg": 202, "End": 227 }, { "InterPro-ID": "IPR025202", "InterPro-Name": "PLD-like_dom", "InterPro-Type": "DOMAIN", "Beg": 467, "End": 587 }, { "InterPro-ID": "IPR001736", "InterPro-Name": "PLipase_D/transphosphatidylase", "InterPro-Type": "DOMAIN", "Beg": 200, "End": 227 }, { "InterPro-ID": "IPR001736", "InterPro-Name": "PLipase_D/transphosphatidylase", "InterPro-Type": "DOMAIN", "Beg": 535, "End": 562 } ], "response#1": "MTFNGRFRATLRGINIRNASMTSLSLTGSHAQKQTVLGSTPGALGTIPTVALNGVNPLPRYRHNLLFGTLSFGDRWDRIQRRLAVLGRASTGNVVVPFSDSADAFRRMWESVDSASDSVLWQTYICKDDFVGQKTVKKLEEAHRRGCKTELLYDCGGNITGRRRLVGDLKKSGANVIEHRPMWEHFFPYFLRGMKWELSPGIRNHRKILIVDNKLGFCGGLNIGDEYCGTSEGGNGRFRDTHCVVMGPAVMHMREVYEDTKAPKPWKWSLARWRQIASATMNLRYLEGMNVKHDYLEPTTTFVRQGGGVYLRRQMERAERSTVRMMERMRWKRQRERLNRCLLTLAKNLREGQGLVFKAATGKGDDVATTDAGSKRNNEVSHGQWKLMKRRIDEYRQRAIKNAEESFFRRLRVVNPSMRLLEDTSPVAEAEAYGQAHAAVTQVLSCNPHSRDWSIPYAFWQVSKFVHQRLWVTTPYYMPHRKLMRALQLAARRGVDVRILAGSNRTTDPWFMWYASNYITGMLMASGVRVYEYKGGQVMHAKTVVADSIWTSIGSYNWDMMSNKNMEICVCHLDHNLALTMEKQFLDDMNVSEEVNYEEYQRRSLWLRFSSWFFYTALRIAEKFTFRTFWDPDLSSEID", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more PLipase_D/transphosphatidylase, PLD-like_dom, PLipase_D/transphosphatidylase, PLipase_D/transphosphatidylase that are essential for its biological function. The designed protein sequence is ", "reference": "MTFNGRFRATLRGINIRNASMTSLSLTGSHAQKQTVLGSTPGALGTIPTVALNGVNPLPRYRHNLLFGTLSFGDRWDRIQRRLAVLGRASTGNVVVPFSDSADAFRRMWESVDSASDSVLWQTYICKDDFVGQKTVKKLEEAHRRGCKTELLYDCGGNITGRRRLVGDLKKSGANVIEHRPMWEHFFPYFLRGMKWELSPGIRNHRKILIVDNKLGFCGGLNIGDEYCGTSEGGNGRFRDTHCVVMGPAVMHMREVYEDTKAPKPWKWSLARWRQIASATMNLRYLEGMNVKHDYLEPTTTFVRQGGGVYLRRQMERAERSTVRMMERMRWKRQRERLNRCLLTLAKNLREGQGLVFKAATGKGDDVATTDAGSKRNNEVSHGQWKLMKRRIDEYRQRAIKNAEESFFRRLRVVNPSMRLLEDTSPVAEAEAYGQAHAAVTQVLSCNPHSRDWSIPYAFWQVSKFVHQRLWVTTPYYMPHRKLMRALQLAARRGVDVRILAGSNRTTDPWFMWYASNYITGMLMASGVRVYEYKGGQVMHAKTVVADSIWTSIGSYNWDMMSNKNMEICVCHLDHNLALTMEKQFLDDMNVSEEVNYEEYQRRSLWLRFSSWFFYTALRIAEKFTFRTFWDPDLSSEID" }, { "InterPro": [ { "InterPro-ID": "IPR000534", "InterPro-Name": "Semialdehyde_DH_NAD-bd", "InterPro-Type": "DOMAIN", "Beg": 8, "End": 134 }, { "InterPro-ID": "IPR000534", "InterPro-Name": "Semialdehyde_DH_NAD-bd", "InterPro-Type": "DOMAIN", "Beg": 9, "End": 132 }, { "InterPro-ID": "IPR051823", "InterPro-Name": "ASADH-related", "InterPro-Type": "FAMILY", "Beg": 5, "End": 363 }, { "InterPro-ID": "IPR036291", "InterPro-Name": "NAD(P)-bd_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 6, "End": 171 }, { "InterPro-ID": "IPR005676", "InterPro-Name": "Asp_semi-ald_DH_pep-lack", "InterPro-Type": "FAMILY", "Beg": 8, "End": 357 }, { "InterPro-ID": "IPR012280", "InterPro-Name": "Semialdhyde_DH_dimer_dom", "InterPro-Type": "DOMAIN", "Beg": 165, "End": 343 } ], "response#1": "MASYPKKKCGVLGATGSVGQRFILLLADHPFLELHAIGASNRSAGKKYKDAVRWKQTTAMSERLSNLVLRDCRADQFSDCDLVFSGLNSDVAGEIEMEFIKAEIPVFSNAKNYRKHPLVPLVVPTVNPQHLDLIPHQRKEFGLKKGFLVCNSNCAVIGVVIPFAALQAKFGPVEEVEVFTEQAVSGAGYPGVPSMDIMDNVIPYISGEEDKLENEAQKILGSLNADATAFDEQKGLTVGATCTRVGVTDGHMAFVSLRFKNRPGPSAEEVKQAMREYQSEAQKLGCPSAPREAIKVFDEPDRPQPRLDRDISKGYTVSVGRVREAAPGSYFDLRFAALSHNTVIGAAGSSILNAEVAVIKGYI", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Semialdehyde_DH_NAD-bd, Semialdehyde_DH_NAD-bd, Semialdhyde_DH_dimer_dom that are essential for its biological function; 2. The protein should belong to ASADH-related, Asp_semi-ald_DH_pep-lack that shares evolutionary origin and functional similarity; 3. The protein should be classified within NAD(P)-bd_dom_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MASYPKKKCGVLGATGSVGQRFILLLADHPFLELHAIGASNRSAGKKYKDAVRWKQTTAMSERLSNLVLRDCRADQFSDCDLVFSGLNSDVAGEIEMEFIKAEIPVFSNAKNYRKHPLVPLVVPTVNPQHLDLIPHQRKEFGLKKGFLVCNSNCAVIGVVIPFAALQAKFGPVEEVEVFTEQAVSGAGYPGVPSMDIMDNVIPYISGEEDKLENEAQKILGSLNADATAFDEQKGLTVGATCTRVGVTDGHMAFVSLRFKNRPGPSAEEVKQAMREYQSEAQKLGCPSAPREAIKVFDEPDRPQPRLDRDISKGYTVSVGRVREAAPGSYFDLRFAALSHNTVIGAAGSSILNAEVAVIKGYI" }, { "InterPro": [ { "InterPro-ID": "IPR001932", "InterPro-Name": "PPM-type_phosphatase-like_dom", "InterPro-Type": "DOMAIN", "Beg": 34, "End": 291 }, { "InterPro-ID": "IPR015655", "InterPro-Name": "PP2C", "InterPro-Type": "FAMILY", "Beg": 20, "End": 288 }, { "InterPro-ID": "IPR036457", "InterPro-Name": "PPM-type-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 14, "End": 291 }, { "InterPro-ID": "IPR000222", "InterPro-Name": "PP2C_BS", "InterPro-Type": "BINDING_SITE", "Beg": 59, "End": 67 }, { "InterPro-ID": "IPR001932", "InterPro-Name": "PPM-type_phosphatase-like_dom", "InterPro-Type": "DOMAIN", "Beg": 17, "End": 275 }, { "InterPro-ID": "IPR001932", "InterPro-Name": "PPM-type_phosphatase-like_dom", "InterPro-Type": "DOMAIN", "Beg": 17, "End": 291 }, { "InterPro-ID": "IPR001932", "InterPro-Name": "PPM-type_phosphatase-like_dom", "InterPro-Type": "DOMAIN", "Beg": 16, "End": 291 }, { "InterPro-ID": "IPR001932", "InterPro-Name": "PPM-type_phosphatase-like_dom", "InterPro-Type": "DOMAIN", "Beg": 6, "End": 289 }, { "InterPro-ID": "IPR036457", "InterPro-Name": "PPM-type-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 2, "End": 300 } ], "response#1": "MRTCGTSSEGQDECCLYGLSAMQGWRISMEDAHAAVLDLQAKSTGGSEKPTDPDKRLAFFGVYDGHGGDKVALFAGENVHKIVAKQEAFAKGDIEQALKDGFLATDRAILEDPKYEEEVSGCTAAVSVISKNKIWVANAGDSRSVLGVKGRAKPLSFDHKPQNEGEKARISAAGGFVDFGRVNGNLALSRAIGDFEFKKSPELSPEQQIVTAYPDVTVHEVTDDDEFLVIACDGIWDCQSSQSVVEFVRRGIAAKQELYRICENMMDNCLASNSETGGVGCDNMTMIIIGLLNGKTKEEWYNQISERVANGDGPCAPPEYGKSEFRGPGIRNQFEETPDNYDLENDRSRGFSVRSGRIILLGDGTELIPEQNDEELFDQREENRDVTNHLQHDKAEETSTAANLSESPSSANKNSSGSGTEATEKSASS", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more PPM-type_phosphatase-like_dom, PPM-type_phosphatase-like_dom, PPM-type_phosphatase-like_dom, PPM-type_phosphatase-like_dom, PPM-type_phosphatase-like_dom that are essential for its biological function; 2. The protein should belong to PP2C that shares evolutionary origin and functional similarity; 3. The protein should be classified within PPM-type-like_dom_sf, PPM-type-like_dom_sf sharing conserved structural features; 4. The protein should include a PP2C_BS that enables ligand binding under diverse conditions. The designed protein sequence is ", "reference": "MRTCGTSSEGQDECCLYGLSAMQGWRISMEDAHAAVLDLQAKSTGGSEKPTDPDKRLAFFGVYDGHGGDKVALFAGENVHKIVAKQEAFAKGDIEQALKDGFLATDRAILEDPKYEEEVSGCTAAVSVISKNKIWVANAGDSRSVLGVKGRAKPLSFDHKPQNEGEKARISAAGGFVDFGRVNGNLALSRAIGDFEFKKSPELSPEQQIVTAYPDVTVHEVTDDDEFLVIACDGIWDCQSSQSVVEFVRRGIAAKQELYRICENMMDNCLASNSETGGVGCDNMTMIIIGLLNGKTKEEWYNQISERVANGDGPCAPPEYGKSEFRGPGIRNQFEETPDNYDLENDRSRGFSVRSGRIILLGDGTELIPEQNDEELFDQREENRDVTNHLQHDKAEETSTAANLSESPSSANKNSSGSGTEATEKSASS" }, { "InterPro": [ { "InterPro-ID": "IPR011990", "InterPro-Name": "TPR-like_helical_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 5, "End": 133 }, { "InterPro-ID": "IPR029052", "InterPro-Name": "Metallo-depent_PP-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 132, "End": 470 }, { "InterPro-ID": "IPR019734", "InterPro-Name": "TPR_rpt", "InterPro-Type": "REPEAT", "Beg": 74, "End": 107 }, { "InterPro-ID": "IPR051134", "InterPro-Name": "PPP_phosphatase", "InterPro-Type": "FAMILY", "Beg": 41, "End": 466 }, { "InterPro-ID": "IPR019734", "InterPro-Name": "TPR_rpt", "InterPro-Type": "REPEAT", "Beg": 7, "End": 40 }, { "InterPro-ID": "IPR019734", "InterPro-Name": "TPR_rpt", "InterPro-Type": "REPEAT", "Beg": 41, "End": 73 }, { "InterPro-ID": "IPR041753", "InterPro-Name": "PP5_C", "InterPro-Type": "DOMAIN", "Beg": 151, "End": 467 }, { "InterPro-ID": "IPR029052", "InterPro-Name": "Metallo-depent_PP-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 161, "End": 467 }, { "InterPro-ID": "IPR004843", "InterPro-Name": "Calcineurin-like_PHP_ApaH", "InterPro-Type": "DOMAIN", "Beg": 212, "End": 406 }, { "InterPro-ID": "IPR006186", "InterPro-Name": "Ser/Thr-sp_prot-phosphatase", "InterPro-Type": "DOMAIN", "Beg": 179, "End": 456 }, { "InterPro-ID": "IPR006186", "InterPro-Name": "Ser/Thr-sp_prot-phosphatase", "InterPro-Type": "DOMAIN", "Beg": 395, "End": 415 }, { "InterPro-ID": "IPR006186", "InterPro-Name": "Ser/Thr-sp_prot-phosphatase", "InterPro-Type": "DOMAIN", "Beg": 241, "End": 268 }, { "InterPro-ID": "IPR006186", "InterPro-Name": "Ser/Thr-sp_prot-phosphatase", "InterPro-Type": "DOMAIN", "Beg": 338, "End": 365 }, { "InterPro-ID": "IPR006186", "InterPro-Name": "Ser/Thr-sp_prot-phosphatase", "InterPro-Type": "DOMAIN", "Beg": 308, "End": 334 }, { "InterPro-ID": "IPR006186", "InterPro-Name": "Ser/Thr-sp_prot-phosphatase", "InterPro-Type": "DOMAIN", "Beg": 417, "End": 433 }, { "InterPro-ID": "IPR006186", "InterPro-Name": "Ser/Thr-sp_prot-phosphatase", "InterPro-Type": "DOMAIN", "Beg": 211, "End": 238 }, { "InterPro-ID": "IPR006186", "InterPro-Name": "Ser/Thr-sp_prot-phosphatase", "InterPro-Type": "DOMAIN", "Beg": 274, "End": 298 }, { "InterPro-ID": "IPR013235", "InterPro-Name": "PPP_dom", "InterPro-Type": "DOMAIN", "Beg": 115, "End": 202 }, { "InterPro-ID": "IPR011990", "InterPro-Name": "TPR-like_helical_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 3, "End": 131 } ], "response#1": "MAGVEEADKLKQLGNAAFSERKWHLAIDMYTKAIELTKTPTLFCNRALAELRAELPGAALADADAALGIEPTFAKAYYHKASAYLSLGKHKQALTNYKKVVDLAPQNSDAQAKVEFCKKEIRRINFENAIMTPDEAPLSQTIKLGSVRADYDGPRIENETVTVEFVEAMKEHFRLEKLIDRHDVIFILLEVQKILKKCPNFVSINVPVGEEITVCGDTHGQYYDLLNIFKLNGNPLETNRYLFNGDFVDRGSYSFENIMTLFAYKVLYPDHFFLSRGNHEGVSMNRMYGFEGEVTQKYNSEMFRLFTEVFNSLPIGHIINNEVFVVHGGLYSSDKVTLDDLQHPNRFRDIPESGLICESLWSDPQPMPGRAPSKRGVSCLSFGPDVTETFLNNNNLKLLVRSHEVKDEGYEIEHGGKCITVFSAPNYCDQMGNKGAFIRFTGGDMKPRFTTFTHVPHPGKRPMHYATGFGLF", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more PP5_C, Calcineurin-like_PHP_ApaH, Ser/Thr-sp_prot-phosphatase, Ser/Thr-sp_prot-phosphatase, Ser/Thr-sp_prot-phosphatase, Ser/Thr-sp_prot-phosphatase, Ser/Thr-sp_prot-phosphatase, Ser/Thr-sp_prot-phosphatase, Ser/Thr-sp_prot-phosphatase, Ser/Thr-sp_prot-phosphatase, PPP_dom that are essential for its biological function; 2. The protein should belong to PPP_phosphatase that shares evolutionary origin and functional similarity; 3. The protein should be classified within TPR-like_helical_dom_sf, Metallo-depent_PP-like, Metallo-depent_PP-like, TPR-like_helical_dom_sf sharing conserved structural features; 4. The protein should include one or more TPR_rpt, TPR_rpt, TPR_rpt that provide structural or functional support. The designed protein sequence is ", "reference": "MAGVEEADKLKQLGNAAFSERKWHLAIDMYTKAIELTKTPTLFCNRALAELRAELPGAALADADAALGIEPTFAKAYYHKASAYLSLGKHKQALTNYKKVVDLAPQNSDAQAKVEFCKKEIRRINFENAIMTPDEAPLSQTIKLGSVRADYDGPRIENETVTVEFVEAMKEHFRLEKLIDRHDVIFILLEVQKILKKCPNFVSINVPVGEEITVCGDTHGQYYDLLNIFKLNGNPLETNRYLFNGDFVDRGSYSFENIMTLFAYKVLYPDHFFLSRGNHEGVSMNRMYGFEGEVTQKYNSEMFRLFTEVFNSLPIGHIINNEVFVVHGGLYSSDKVTLDDLQHPNRFRDIPESGLICESLWSDPQPMPGRAPSKRGVSCLSFGPDVTETFLNNNNLKLLVRSHEVKDEGYEIEHGGKCITVFSAPNYCDQMGNKGAFIRFTGGDMKPRFTTFTHVPHPGKRPMHYATGFGLF" }, { "InterPro": [ { "InterPro-ID": "IPR012338", "InterPro-Name": "Beta-lactam/transpept-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 55, "End": 272 }, { "InterPro-ID": "IPR001460", "InterPro-Name": "PCN-bd_Tpept", "InterPro-Type": "DOMAIN", "Beg": 66, "End": 268 }, { "InterPro-ID": "IPR012338", "InterPro-Name": "Beta-lactam/transpept-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 38, "End": 280 }, { "InterPro-ID": "IPR050515", "InterPro-Name": "Bact_Transpept/Beta-Lactamase", "InterPro-Type": "FAMILY", "Beg": 53, "End": 161 }, { "InterPro-ID": "IPR002137", "InterPro-Name": "Beta-lactam_class-D_AS", "InterPro-Type": "ACTIVE_SITE", "Beg": 81, "End": 91 } ], "response#1": "MKLLKILSLVCLSISIGACAEHSMSRAKTSTIPQVNNSIIDQNVQALFNEISADAVFVTYDGQNIKKYGTHLDRAKTAYIPASTFKIANALIGLENHKATSTEIFKWDGKPRFFKAWDKDFTLGEAMQASTVPVYQELARRIGPSLMQSELQRIGYGNMQIGTEVDQFWLKGPLTITPIQEVKFVYDLAQGQLPFKPEVQQQVKEMLYVERRGENRLYAKSGWGMAVDPQVGWYVGFVEKADGQVVAFALNMQMKAGDDIALRKQLSLDVLDKLGVFHYL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more PCN-bd_Tpept that are essential for its biological function; 2. The protein should belong to Bact_Transpept/Beta-Lactamase that shares evolutionary origin and functional similarity; 3. The protein should be classified within Beta-lactam/transpept-like, Beta-lactam/transpept-like sharing conserved structural features; 4. The protein must have Beta-lactam_class-D_AS that is conserved among related catalytic enzymes. The designed protein sequence is ", "reference": "MKLLKILSLVCLSISIGACAEHSMSRAKTSTIPQVNNSIIDQNVQALFNEISADAVFVTYDGQNIKKYGTHLDRAKTAYIPASTFKIANALIGLENHKATSTEIFKWDGKPRFFKAWDKDFTLGEAMQASTVPVYQELARRIGPSLMQSELQRIGYGNMQIGTEVDQFWLKGPLTITPIQEVKFVYDLAQGQLPFKPEVQQQVKEMLYVERRGENRLYAKSGWGMAVDPQVGWYVGFVEKADGQVVAFALNMQMKAGDDIALRKQLSLDVLDKLGVFHYL" }, { "InterPro": [ { "InterPro-ID": "IPR013210", "InterPro-Name": "LRR_N_plant-typ", "InterPro-Type": "DOMAIN", "Beg": 328, "End": 363 }, { "InterPro-ID": "IPR013210", "InterPro-Name": "LRR_N_plant-typ", "InterPro-Type": "DOMAIN", "Beg": 44, "End": 59 }, { "InterPro-ID": "IPR001611", "InterPro-Name": "Leu-rich_rpt", "InterPro-Type": "REPEAT", "Beg": 186, "End": 208 }, { "InterPro-ID": "IPR011009", "InterPro-Name": "Kinase-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 558, "End": 855 }, { "InterPro-ID": "IPR000719", "InterPro-Name": "Prot_kinase_dom", "InterPro-Type": "DOMAIN", "Beg": 580, "End": 859 }, { "InterPro-ID": "IPR052422", "InterPro-Name": "Auxin_Ser/Thr_Kinase", "InterPro-Type": "FAMILY", "Beg": 12, "End": 894 }, { "InterPro-ID": "IPR003591", "InterPro-Name": "Leu-rich_rpt_typical-subtyp", "InterPro-Type": "REPEAT", "Beg": 412, "End": 434 }, { "InterPro-ID": "IPR003591", "InterPro-Name": "Leu-rich_rpt_typical-subtyp", "InterPro-Type": "REPEAT", "Beg": 111, "End": 134 }, { "InterPro-ID": "IPR003591", "InterPro-Name": "Leu-rich_rpt_typical-subtyp", "InterPro-Type": "REPEAT", "Beg": 184, "End": 208 }, { "InterPro-ID": "IPR003591", "InterPro-Name": "Leu-rich_rpt_typical-subtyp", "InterPro-Type": "REPEAT", "Beg": 88, "End": 110 }, { "InterPro-ID": "IPR003591", "InterPro-Name": "Leu-rich_rpt_typical-subtyp", "InterPro-Type": "REPEAT", "Beg": 388, "End": 411 }, { "InterPro-ID": "IPR032675", "InterPro-Name": "LRR_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 326, "End": 444 }, { "InterPro-ID": "IPR000719", "InterPro-Name": "Prot_kinase_dom", "InterPro-Type": "DOMAIN", "Beg": 584, "End": 853 }, { "InterPro-ID": "IPR032675", "InterPro-Name": "LRR_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 26, "End": 311 }, { "InterPro-ID": "IPR008271", "InterPro-Name": "Ser/Thr_kinase_AS", "InterPro-Type": "ACTIVE_SITE", "Beg": 704, "End": 716 }, { "InterPro-ID": "IPR017441", "InterPro-Name": "Protein_kinase_ATP_BS", "InterPro-Type": "BINDING_SITE", "Beg": 586, "End": 607 }, { "InterPro-ID": "IPR001611", "InterPro-Name": "Leu-rich_rpt", "InterPro-Type": "REPEAT", "Beg": 370, "End": 425 } ], "response#1": "MGRDARRLPLLPFLLLLLAAAAGVAESATDAEAIHDLARSVPALGWDGDNVCGFEGVTCERGGAGKVTELNLADRGLSGTLPDSLSSLTSLTALQLQGNALTGAVPSLARMGSLARLALDGNAFTSLPPDFLHGLTSLQYLTMENLPLPPWPVPDAIANCSSLDTFSASNASISGPFPAVLATLVSLRNLRLSYNNLTGGLPPELSSLIAMESLQLNNQRSDDKLSGPIDVIASMKSLKLLWIQSNKFTGPIPDLNGTQLEAFNVRDNMLTGVVPPSLTGLMSLKNVSLSNNNFQGPKPAFAAIPGQDEDSGNGFCLNTPGPCSPLTTTLLQVAEGFGYPYELAKTWKGNDPCSPAWVGIVCTSSDVSMINLSRKNLSGRISPALANLTRLARLDLSNNNLTGVIPDVLTTLPSLTVLNVANNRLTGEVPKFKPSVNVLAQGNLFGQSSGSSGGGGGSDGDSSSSDSAGGGKSKPNTGMIIGIIVAVIILFACIALLVHHRKKKNVEKFRPVSTKTSPAESEMMKIQVVGANGISNGSSAFPTELYSHVSAANSSNISELFESHGMQLSVEVLLKATNNFSEDCILGRGGFGVVFKGNLNGKLVAVKRCDSGTMGTKGQEEFLAEIDVLRKVRHRHLVALLGYCTHGNERLLVYEYMSGGTLREHLCDLQQSGFIPLTWTQRMTIALDVARGIEYLHGLAQETFIHRDLKPSNILLDQDLRAKVSDFGLVKLAKDTDKSLMTRIAGTFGYLAPEYATTGKVTTKVDVYAYGVILMEMITGRKVLDDSLPDDETHLVTIFRRNILDKEKFRKFVDPTLELSAEGWTSLLEVADLARHCTAREPYQRPDMCHCVNRLSSLVDQWKPTNIDEDDYEGETSEMGLHQQLEKWRCDDFTISDSDTFGSFNVPRKYNG", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more LRR_N_plant-typ, LRR_N_plant-typ, Prot_kinase_dom, Prot_kinase_dom that are essential for its biological function; 2. The protein should belong to Auxin_Ser/Thr_Kinase that shares evolutionary origin and functional similarity; 3. The protein should be classified within Kinase-like_dom_sf, LRR_dom_sf, LRR_dom_sf sharing conserved structural features; 4. The protein should include one or more Leu-rich_rpt, Leu-rich_rpt_typical-subtyp, Leu-rich_rpt_typical-subtyp, Leu-rich_rpt_typical-subtyp, Leu-rich_rpt_typical-subtyp, Leu-rich_rpt_typical-subtyp, Leu-rich_rpt that provide structural or functional support; 5. The protein must have Ser/Thr_kinase_AS that is conserved among related catalytic enzymes; 6. The protein should include a Protein_kinase_ATP_BS that enables ligand binding under diverse conditions. The designed protein sequence is ", "reference": "MGRDARRLPLLPFLLLLLAAAAGVAESATDAEAIHDLARSVPALGWDGDNVCGFEGVTCERGGAGKVTELNLADRGLSGTLPDSLSSLTSLTALQLQGNALTGAVPSLARMGSLARLALDGNAFTSLPPDFLHGLTSLQYLTMENLPLPPWPVPDAIANCSSLDTFSASNASISGPFPAVLATLVSLRNLRLSYNNLTGGLPPELSSLIAMESLQLNNQRSDDKLSGPIDVIASMKSLKLLWIQSNKFTGPIPDLNGTQLEAFNVRDNMLTGVVPPSLTGLMSLKNVSLSNNNFQGPKPAFAAIPGQDEDSGNGFCLNTPGPCSPLTTTLLQVAEGFGYPYELAKTWKGNDPCSPAWVGIVCTSSDVSMINLSRKNLSGRISPALANLTRLARLDLSNNNLTGVIPDVLTTLPSLTVLNVANNRLTGEVPKFKPSVNVLAQGNLFGQSSGSSGGGGGSDGDSSSSDSAGGGKSKPNTGMIIGIIVAVIILFACIALLVHHRKKKNVEKFRPVSTKTSPAESEMMKIQVVGANGISNGSSAFPTELYSHVSAANSSNISELFESHGMQLSVEVLLKATNNFSEDCILGRGGFGVVFKGNLNGKLVAVKRCDSGTMGTKGQEEFLAEIDVLRKVRHRHLVALLGYCTHGNERLLVYEYMSGGTLREHLCDLQQSGFIPLTWTQRMTIALDVARGIEYLHGLAQETFIHRDLKPSNILLDQDLRAKVSDFGLVKLAKDTDKSLMTRIAGTFGYLAPEYATTGKVTTKVDVYAYGVILMEMITGRKVLDDSLPDDETHLVTIFRRNILDKEKFRKFVDPTLELSAEGWTSLLEVADLARHCTAREPYQRPDMCHCVNRLSSLVDQWKPTNIDEDDYEGETSEMGLHQQLEKWRCDDFTISDSDTFGSFNVPRKYNG" }, { "InterPro": [ { "InterPro-ID": "IPR020806", "InterPro-Name": "PKS_PP-bd", "InterPro-Type": "DOMAIN", "Beg": 943, "End": 1012 }, { "InterPro-ID": "IPR010071", "InterPro-Name": "AA_adenyl_dom", "InterPro-Type": "DOMAIN", "Beg": 44, "End": 455 }, { "InterPro-ID": "IPR006162", "InterPro-Name": "Ppantetheine_attach_site", "InterPro-Type": "PTM", "Beg": 967, "End": 982 }, { "InterPro-ID": "IPR000873", "InterPro-Name": "AMP-dep_synth/lig_dom", "InterPro-Type": "DOMAIN", "Beg": 24, "End": 379 }, { "InterPro-ID": "IPR009081", "InterPro-Name": "PP-bd_ACP", "InterPro-Type": "DOMAIN", "Beg": 937, "End": 1012 }, { "InterPro-ID": "IPR000415", "InterPro-Name": "Nitroreductase-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 538, "End": 723 }, { "InterPro-ID": "IPR045851", "InterPro-Name": "AMP-bd_C_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 425, "End": 509 }, { "InterPro-ID": "IPR020459", "InterPro-Name": "AMP-binding", "InterPro-Type": "DOMAIN", "Beg": 164, "End": 175 }, { "InterPro-ID": "IPR020459", "InterPro-Name": "AMP-binding", "InterPro-Type": "DOMAIN", "Beg": 176, "End": 184 }, { "InterPro-ID": "IPR029058", "InterPro-Name": "AB_hydrolase_fold", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1009, "End": 1276 }, { "InterPro-ID": "IPR020845", "InterPro-Name": "AMP-binding_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 169, "End": 180 }, { "InterPro-ID": "IPR036736", "InterPro-Name": "ACP-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 936, "End": 1009 }, { "InterPro-ID": "IPR036736", "InterPro-Name": "ACP-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 931, "End": 1016 }, { "InterPro-ID": "IPR029058", "InterPro-Name": "AB_hydrolase_fold", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1019, "End": 1282 }, { "InterPro-ID": "IPR042099", "InterPro-Name": "ANL_N_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 16, "End": 424 }, { "InterPro-ID": "IPR001031", "InterPro-Name": "Thioesterase", "InterPro-Type": "DOMAIN", "Beg": 1030, "End": 1138 }, { "InterPro-ID": "IPR045851", "InterPro-Name": "AMP-bd_C_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 839, "End": 930 }, { "InterPro-ID": "IPR009081", "InterPro-Name": "PP-bd_ACP", "InterPro-Type": "DOMAIN", "Beg": 945, "End": 1008 } ], "response#1": "MTLQETSVLEPTLQGTTTLPGLLAQRVAEHPEAIAVAYRDDKLTFRELASRSAALADYLEHLGVSADDCVGLFVEPSIDLMVGAWGILNAGAAYLPLSPEYPEDRLRYMIENSETKIILAQQRLVSRLRELAPKDVTIVTLRESEAFVRPEGTEAPAARSARPDTLAYVIYTSGSTGKPKGVMIEHRSIVNQLGWLRETYAIDRSKVILQKTPMSFDAAQWEILSPANGATVVMGAPGVYADPEGLIETIVKHNVTTLQCVPTLLQGLIDTEKFPECVSLQQIFSGGEALSRLLAIQTTQEMPGRALINVYGPTETTINSSSFPVDPADLDEGPQSISIGSPVHGTTYHILDKETLKPVGVGEIGELYIGGIQLARGYLHRDDLTAERFLEIELEEGAEPVRLYKTGDLGQWNNDGTVQFAGRADNQVKLRGYRVELDEISLAIENHDWVRNAAVIVKNDGRTGFQNLIACIELSEKEAALMDQGNHGSHHASKKSKLQVKAQLSNPGLRDDAELAARPAFDLEGAEPTPEQRARVFARKTYRFYEGGAVTQADLLGLLGATVTAGYSRKAADLAPAELGQILRWFGQYISEERLLPKYGYASPGALYATQMYFELEGVGGLKPGYYYYQPVRHQLVLISEREATGKATAQIHFIGKKSGIEPVYKNNILEVLEIETGHMVGLFEQILPAYGLDIHDRAYEPAVKDLLDVADEDYYLGTFELVPHAGARDDQAEVYVQTHGGKVAGLPEGQYRYENGELTRFSDDIVLKKHVIAINQSVYQAASFGISVYSRAEEEWLKYITLGKKLQHLMMNGLNLGFMSSGYSSKTGNPLPASRRMDAVLGANGVDSAPMYFFVGGRISDEQIGHEGMREDSVHMRGPAELIRDDLVSFLPDYMIPNRVVVFDRLPLSANGKIDVKALAASDQVNAELVERPFVAPRTETEKEIAAVWEKALRRENASVQDDFFESGGNSLIAVGLVRELNARLGVSLPLQSVLESPTIEKLARRLEREVAQESSRFVRLHAETGKARPVICWPGLGGYPMNLRSLAGEIGLGRSFYGVQSYGINEGETPYETITEMAKKDIEALKEIQPAGPYTLWGYSFGARVAFETAYQLEQAGEKVDNLFLIAPGSPKVRAENGKVWGREASFANRGYTTILFSVFTGTISGPDLDRCLETVTDEASFAEFISELKGIDVDLARRIISVVGQTYEFEYSFHELAERTLQAPISIFKAVGDDYSFLENSSGYSAEPPTVIDLDADHYSLLREDIGELVKHIRYLLGE", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more PKS_PP-bd, AA_adenyl_dom, AMP-dep_synth/lig_dom, PP-bd_ACP, AMP-binding, AMP-binding, Thioesterase, PP-bd_ACP that are essential for its biological function; 2. The protein should be classified within Nitroreductase-like, AMP-bd_C_sf, AB_hydrolase_fold, ACP-like_sf, ACP-like_sf, AB_hydrolase_fold, ANL_N_sf, AMP-bd_C_sf sharing conserved structural features; 3. The protein should contain AMP-binding_CS that is preserved across related proteins; 4. The protein should contain Ppantetheine_attach_site that allow regulation through chemical modifications. The designed protein sequence is ", "reference": "MTLQETSVLEPTLQGTTTLPGLLAQRVAEHPEAIAVAYRDDKLTFRELASRSAALADYLEHLGVSADDCVGLFVEPSIDLMVGAWGILNAGAAYLPLSPEYPEDRLRYMIENSETKIILAQQRLVSRLRELAPKDVTIVTLRESEAFVRPEGTEAPAARSARPDTLAYVIYTSGSTGKPKGVMIEHRSIVNQLGWLRETYAIDRSKVILQKTPMSFDAAQWEILSPANGATVVMGAPGVYADPEGLIETIVKHNVTTLQCVPTLLQGLIDTEKFPECVSLQQIFSGGEALSRLLAIQTTQEMPGRALINVYGPTETTINSSSFPVDPADLDEGPQSISIGSPVHGTTYHILDKETLKPVGVGEIGELYIGGIQLARGYLHRDDLTAERFLEIELEEGAEPVRLYKTGDLGQWNNDGTVQFAGRADNQVKLRGYRVELDEISLAIENHDWVRNAAVIVKNDGRTGFQNLIACIELSEKEAALMDQGNHGSHHASKKSKLQVKAQLSNPGLRDDAELAARPAFDLEGAEPTPEQRARVFARKTYRFYEGGAVTQADLLGLLGATVTAGYSRKAADLAPAELGQILRWFGQYISEERLLPKYGYASPGALYATQMYFELEGVGGLKPGYYYYQPVRHQLVLISEREATGKATAQIHFIGKKSGIEPVYKNNILEVLEIETGHMVGLFEQILPAYGLDIHDRAYEPAVKDLLDVADEDYYLGTFELVPHAGARDDQAEVYVQTHGGKVAGLPEGQYRYENGELTRFSDDIVLKKHVIAINQSVYQAASFGISVYSRAEEEWLKYITLGKKLQHLMMNGLNLGFMSSGYSSKTGNPLPASRRMDAVLGANGVDSAPMYFFVGGRISDEQIGHEGMREDSVHMRGPAELIRDDLVSFLPDYMIPNRVVVFDRLPLSANGKIDVKALAASDQVNAELVERPFVAPRTETEKEIAAVWEKALRRENASVQDDFFESGGNSLIAVGLVRELNARLGVSLPLQSVLESPTIEKLARRLEREVAQESSRFVRLHAETGKARPVICWPGLGGYPMNLRSLAGEIGLGRSFYGVQSYGINEGETPYETITEMAKKDIEALKEIQPAGPYTLWGYSFGARVAFETAYQLEQAGEKVDNLFLIAPGSPKVRAENGKVWGREASFANRGYTTILFSVFTGTISGPDLDRCLETVTDEASFAEFISELKGIDVDLARRIISVVGQTYEFEYSFHELAERTLQAPISIFKAVGDDYSFLENSSGYSAEPPTVIDLDADHYSLLREDIGELVKHIRYLLGE" }, { "InterPro": [ { "InterPro-ID": "IPR006578", "InterPro-Name": "MADF-dom", "InterPro-Type": "DOMAIN", "Beg": 201, "End": 292 }, { "InterPro-ID": "IPR013087", "InterPro-Name": "Znf_C2H2_type", "InterPro-Type": "DOMAIN", "Beg": 506, "End": 527 }, { "InterPro-ID": "IPR036236", "InterPro-Name": "Znf_C2H2_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 485, "End": 542 }, { "InterPro-ID": "IPR013087", "InterPro-Name": "Znf_C2H2_type", "InterPro-Type": "DOMAIN", "Beg": 562, "End": 583 }, { "InterPro-ID": "IPR013087", "InterPro-Name": "Znf_C2H2_type", "InterPro-Type": "DOMAIN", "Beg": 533, "End": 555 }, { "InterPro-ID": "IPR036236", "InterPro-Name": "Znf_C2H2_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 531, "End": 583 }, { "InterPro-ID": "IPR013087", "InterPro-Name": "Znf_C2H2_type", "InterPro-Type": "DOMAIN", "Beg": 504, "End": 527 }, { "InterPro-ID": "IPR013087", "InterPro-Name": "Znf_C2H2_type", "InterPro-Type": "DOMAIN", "Beg": 476, "End": 498 }, { "InterPro-ID": "IPR013087", "InterPro-Name": "Znf_C2H2_type", "InterPro-Type": "DOMAIN", "Beg": 561, "End": 583 }, { "InterPro-ID": "IPR013087", "InterPro-Name": "Znf_C2H2_type", "InterPro-Type": "DOMAIN", "Beg": 418, "End": 441 }, { "InterPro-ID": "IPR013087", "InterPro-Name": "Znf_C2H2_type", "InterPro-Type": "DOMAIN", "Beg": 448, "End": 471 }, { "InterPro-ID": "IPR013087", "InterPro-Name": "Znf_C2H2_type", "InterPro-Type": "DOMAIN", "Beg": 18, "End": 43 }, { "InterPro-ID": "IPR013087", "InterPro-Name": "Znf_C2H2_type", "InterPro-Type": "DOMAIN", "Beg": 535, "End": 555 }, { "InterPro-ID": "IPR013087", "InterPro-Name": "Znf_C2H2_type", "InterPro-Type": "DOMAIN", "Beg": 448, "End": 476 }, { "InterPro-ID": "IPR006578", "InterPro-Name": "MADF-dom", "InterPro-Type": "DOMAIN", "Beg": 321, "End": 408 }, { "InterPro-ID": "IPR006578", "InterPro-Name": "MADF-dom", "InterPro-Type": "DOMAIN", "Beg": 202, "End": 287 }, { "InterPro-ID": "IPR013087", "InterPro-Name": "Znf_C2H2_type", "InterPro-Type": "DOMAIN", "Beg": 533, "End": 560 }, { "InterPro-ID": "IPR036236", "InterPro-Name": "Znf_C2H2_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 418, "End": 467 }, { "InterPro-ID": "IPR013087", "InterPro-Name": "Znf_C2H2_type", "InterPro-Type": "DOMAIN", "Beg": 476, "End": 503 }, { "InterPro-ID": "IPR013087", "InterPro-Name": "Znf_C2H2_type", "InterPro-Type": "DOMAIN", "Beg": 478, "End": 498 }, { "InterPro-ID": "IPR013087", "InterPro-Name": "Znf_C2H2_type", "InterPro-Type": "DOMAIN", "Beg": 420, "End": 441 }, { "InterPro-ID": "IPR013087", "InterPro-Name": "Znf_C2H2_type", "InterPro-Type": "DOMAIN", "Beg": 450, "End": 471 }, { "InterPro-ID": "IPR013087", "InterPro-Name": "Znf_C2H2_type", "InterPro-Type": "DOMAIN", "Beg": 563, "End": 583 }, { "InterPro-ID": "IPR006578", "InterPro-Name": "MADF-dom", "InterPro-Type": "DOMAIN", "Beg": 320, "End": 413 }, { "InterPro-ID": "IPR013087", "InterPro-Name": "Znf_C2H2_type", "InterPro-Type": "DOMAIN", "Beg": 561, "End": 586 }, { "InterPro-ID": "IPR013087", "InterPro-Name": "Znf_C2H2_type", "InterPro-Type": "DOMAIN", "Beg": 504, "End": 532 } ], "response#1": "MELCGNVMTNSKYEMFRLKCLYCSIESELKDWELFIVHVKSAHYCEDEDVRINEIKEDTEELYSVVDAADPAIAYGPDEFFEVIENSNGVDQWMEADSKDIQYEEDATAWSAATNNSWEFGPGGSSLELPAGKEVTQMDESSQNHIPLNTDDDDVDCSDFFMSEDDLAPPRKPGRPPRRTRPGQVFKFKVSFIRSNPRVLHLIQAYKEHPCLWNPSDEHYQDEPARSMAYEAIMERMDRKANVLFTVEELKKTLEQLHVQYTLALETKQRGKLVGLAARYFAKCEFLSVAPVVTPRENEEDNDLTAIKLNFKEENLITTSFIETYANYPVLYNQALPDFGSIEIRADAFKRMAKEFQPVVKANETDVYIAVNKLRRWLYDAIRRLKSKELIQKCSKQEVQYLQMCSFLPAKGSESQVLYCDYCDKRFHGDYNLRVHIVKAHEVGDLPYLCSFCPRRFDRHVDMDRHKLRSHFERKLKCQYCEKSFAVDTDLKVHTLIHTGERPHVCDICGKTFRLKLLLDHHVNGVHLNIRPYSCNMCTKTFRKKFELANHIKGHLNIRDKKCEYCDATFYDHSSLSRHRRSHRSE", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more MADF-dom, Znf_C2H2_type, Znf_C2H2_type, Znf_C2H2_type, Znf_C2H2_type, Znf_C2H2_type, Znf_C2H2_type, Znf_C2H2_type, Znf_C2H2_type, Znf_C2H2_type, Znf_C2H2_type, Znf_C2H2_type, MADF-dom, MADF-dom, Znf_C2H2_type, Znf_C2H2_type, Znf_C2H2_type, Znf_C2H2_type, Znf_C2H2_type, Znf_C2H2_type, MADF-dom, Znf_C2H2_type, Znf_C2H2_type that are essential for its biological function; 2. The protein should be classified within Znf_C2H2_sf, Znf_C2H2_sf, Znf_C2H2_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MELCGNVMTNSKYEMFRLKCLYCSIESELKDWELFIVHVKSAHYCEDEDVRINEIKEDTEELYSVVDAADPAIAYGPDEFFEVIENSNGVDQWMEADSKDIQYEEDATAWSAATNNSWEFGPGGSSLELPAGKEVTQMDESSQNHIPLNTDDDDVDCSDFFMSEDDLAPPRKPGRPPRRTRPGQVFKFKVSFIRSNPRVLHLIQAYKEHPCLWNPSDEHYQDEPARSMAYEAIMERMDRKANVLFTVEELKKTLEQLHVQYTLALETKQRGKLVGLAARYFAKCEFLSVAPVVTPRENEEDNDLTAIKLNFKEENLITTSFIETYANYPVLYNQALPDFGSIEIRADAFKRMAKEFQPVVKANETDVYIAVNKLRRWLYDAIRRLKSKELIQKCSKQEVQYLQMCSFLPAKGSESQVLYCDYCDKRFHGDYNLRVHIVKAHEVGDLPYLCSFCPRRFDRHVDMDRHKLRSHFERKLKCQYCEKSFAVDTDLKVHTLIHTGERPHVCDICGKTFRLKLLLDHHVNGVHLNIRPYSCNMCTKTFRKKFELANHIKGHLNIRDKKCEYCDATFYDHSSLSRHRRSHRSE" }, { "InterPro": [ { "InterPro-ID": "IPR002350", "InterPro-Name": "Kazal_dom", "InterPro-Type": "DOMAIN", "Beg": 29, "End": 76 }, { "InterPro-ID": "IPR036058", "InterPro-Name": "Kazal_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 20, "End": 76 }, { "InterPro-ID": "IPR002350", "InterPro-Name": "Kazal_dom", "InterPro-Type": "DOMAIN", "Beg": 25, "End": 78 }, { "InterPro-ID": "IPR002350", "InterPro-Name": "Kazal_dom", "InterPro-Type": "DOMAIN", "Beg": 30, "End": 76 }, { "InterPro-ID": "IPR002350", "InterPro-Name": "Kazal_dom", "InterPro-Type": "DOMAIN", "Beg": 33, "End": 56 }, { "InterPro-ID": "IPR053265", "InterPro-Name": "Serpin", "InterPro-Type": "FAMILY", "Beg": 23, "End": 61 } ], "response#1": "MRHIGVFVGVLALALVLLVVEARSDAERGVCACPRIYMPVCGSNLKTYNNDCLLRCEINSDLGRANNLRKIADQACDNLTDNVNDFIPQEY", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Kazal_dom, Kazal_dom, Kazal_dom, Kazal_dom that are essential for its biological function; 2. The protein should belong to Serpin that shares evolutionary origin and functional similarity; 3. The protein should be classified within Kazal_dom_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MRHIGVFVGVLALALVLLVVEARSDAERGVCACPRIYMPVCGSNLKTYNNDCLLRCEINSDLGRANNLRKIADQACDNLTDNVNDFIPQEY" }, { "InterPro": [ { "InterPro-ID": "IPR002403", "InterPro-Name": "Cyt_P450_E_grp-IV", "InterPro-Type": "FAMILY", "Beg": 469, "End": 485 }, { "InterPro-ID": "IPR002403", "InterPro-Name": "Cyt_P450_E_grp-IV", "InterPro-Type": "FAMILY", "Beg": 317, "End": 343 }, { "InterPro-ID": "IPR002403", "InterPro-Name": "Cyt_P450_E_grp-IV", "InterPro-Type": "FAMILY", "Beg": 72, "End": 89 }, { "InterPro-ID": "IPR002403", "InterPro-Name": "Cyt_P450_E_grp-IV", "InterPro-Type": "FAMILY", "Beg": 413, "End": 427 }, { "InterPro-ID": "IPR002403", "InterPro-Name": "Cyt_P450_E_grp-IV", "InterPro-Type": "FAMILY", "Beg": 485, "End": 503 }, { "InterPro-ID": "IPR002403", "InterPro-Name": "Cyt_P450_E_grp-IV", "InterPro-Type": "FAMILY", "Beg": 94, "End": 117 }, { "InterPro-ID": "IPR002403", "InterPro-Name": "Cyt_P450_E_grp-IV", "InterPro-Type": "FAMILY", "Beg": 429, "End": 447 }, { "InterPro-ID": "IPR002403", "InterPro-Name": "Cyt_P450_E_grp-IV", "InterPro-Type": "FAMILY", "Beg": 378, "End": 394 }, { "InterPro-ID": "IPR017972", "InterPro-Name": "Cyt_P450_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 478, "End": 487 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 76, "End": 536 }, { "InterPro-ID": "IPR036396", "InterPro-Name": "Cyt_P450_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 65, "End": 540 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 326, "End": 343 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 476, "End": 485 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 485, "End": 496 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 383, "End": 394 }, { "InterPro-ID": "IPR036396", "InterPro-Name": "Cyt_P450_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 69, "End": 540 }, { "InterPro-ID": "IPR050529", "InterPro-Name": "CYP450_sterol_14alpha_dmase", "InterPro-Type": "FAMILY", "Beg": 53, "End": 532 } ], "response#1": "MGLSHSGEIVYIHPSSPVDLFTTCASLPTKPPPSFSDMPSPLFLVSGFLGVCVAYAVANIIRQLLFPNAKEPPVVFHWFPWLGSALTYGKDPYKFLFAARAKYGDVFTFVLLGRNVTVHLGVAGNDFVFNGKETHMNAEEIYGPLCNPVFGEGVVYDCPNSKLMEQKKFVKFGLTTDALKAHVRLIEHEVVNYIKSSRDFKGPSGVINVPPVMAQITIFTAAIALQGPEVRSKLTNEFASLYHDLDGGFSPINFVLPHAPFPHNIKRDRAQLKMRKIYEAIIAERRAGKIPPTTDMISHLMQCSYKNGRPIPDSEISNMMITILMAGQHNSSNIASWIMLHLANEPQLCEELYQEQLDQLADEHGNLPELELHTVEKLKLHSSVVKETLRMHNAIHSIMRLVKQPLPVPNTSWTVPPGHAVLASPGVSANSNEYFLNPTKWDPHRWDDRVIEEDDESEMVDYGYGRTSRGTKSAYLPFGGGRHRCIGEKFAYLNLEVITAVMVRNFRFKNVDGRVDVPGTDYSTMFSRPLEPAEICWERR", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Cyt_P450_E_grp-IV, Cyt_P450_E_grp-IV, Cyt_P450_E_grp-IV, Cyt_P450_E_grp-IV, Cyt_P450_E_grp-IV, Cyt_P450_E_grp-IV, Cyt_P450_E_grp-IV, Cyt_P450_E_grp-IV, Cyt_P450, Cyt_P450, Cyt_P450, Cyt_P450, Cyt_P450, CYP450_sterol_14alpha_dmase that shares evolutionary origin and functional similarity; 2. The protein should be classified within Cyt_P450_sf, Cyt_P450_sf sharing conserved structural features; 3. The protein should contain Cyt_P450_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MGLSHSGEIVYIHPSSPVDLFTTCASLPTKPPPSFSDMPSPLFLVSGFLGVCVAYAVANIIRQLLFPNAKEPPVVFHWFPWLGSALTYGKDPYKFLFAARAKYGDVFTFVLLGRNVTVHLGVAGNDFVFNGKETHMNAEEIYGPLCNPVFGEGVVYDCPNSKLMEQKKFVKFGLTTDALKAHVRLIEHEVVNYIKSSRDFKGPSGVINVPPVMAQITIFTAAIALQGPEVRSKLTNEFASLYHDLDGGFSPINFVLPHAPFPHNIKRDRAQLKMRKIYEAIIAERRAGKIPPTTDMISHLMQCSYKNGRPIPDSEISNMMITILMAGQHNSSNIASWIMLHLANEPQLCEELYQEQLDQLADEHGNLPELELHTVEKLKLHSSVVKETLRMHNAIHSIMRLVKQPLPVPNTSWTVPPGHAVLASPGVSANSNEYFLNPTKWDPHRWDDRVIEEDDESEMVDYGYGRTSRGTKSAYLPFGGGRHRCIGEKFAYLNLEVITAVMVRNFRFKNVDGRVDVPGTDYSTMFSRPLEPAEICWERR" }, { "InterPro": [ { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 442, "End": 451 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 451, "End": 462 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 350, "End": 361 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 292, "End": 309 }, { "InterPro-ID": "IPR036396", "InterPro-Name": "Cyt_P450_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 32, "End": 506 }, { "InterPro-ID": "IPR017972", "InterPro-Name": "Cyt_P450_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 444, "End": 453 }, { "InterPro-ID": "IPR002403", "InterPro-Name": "Cyt_P450_E_grp-IV", "InterPro-Type": "FAMILY", "Beg": 58, "End": 81 }, { "InterPro-ID": "IPR002403", "InterPro-Name": "Cyt_P450_E_grp-IV", "InterPro-Type": "FAMILY", "Beg": 451, "End": 469 }, { "InterPro-ID": "IPR002403", "InterPro-Name": "Cyt_P450_E_grp-IV", "InterPro-Type": "FAMILY", "Beg": 396, "End": 414 }, { "InterPro-ID": "IPR002403", "InterPro-Name": "Cyt_P450_E_grp-IV", "InterPro-Type": "FAMILY", "Beg": 380, "End": 394 }, { "InterPro-ID": "IPR002403", "InterPro-Name": "Cyt_P450_E_grp-IV", "InterPro-Type": "FAMILY", "Beg": 345, "End": 361 }, { "InterPro-ID": "IPR002403", "InterPro-Name": "Cyt_P450_E_grp-IV", "InterPro-Type": "FAMILY", "Beg": 435, "End": 451 }, { "InterPro-ID": "IPR002403", "InterPro-Name": "Cyt_P450_E_grp-IV", "InterPro-Type": "FAMILY", "Beg": 36, "End": 53 }, { "InterPro-ID": "IPR002403", "InterPro-Name": "Cyt_P450_E_grp-IV", "InterPro-Type": "FAMILY", "Beg": 283, "End": 309 }, { "InterPro-ID": "IPR036396", "InterPro-Name": "Cyt_P450_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 33, "End": 511 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 40, "End": 480 }, { "InterPro-ID": "IPR050529", "InterPro-Name": "CYP450_sterol_14alpha_dmase", "InterPro-Type": "FAMILY", "Beg": 8, "End": 499 } ], "response#1": "MSILWIVAYALLAFAASIALNLVYQFLYRTFNKSRPPLVFHWVPFIGSTIHYGMDPYNFFFSCREKYGDIFTFILLGRPTTVYLGTQGNEFILNGKLKDVNAEEVYSPLTTPVFGSDVVYDCPNSKLIEQKKFIKFGLSQAALEAHVPLIEKEVIDYLAQSPNFNGTAGTVDIASAMAEITIFTAGSTLQGEEVRSKLTTEFAVLYHDLDKGFTPINFMLPWAPLPHNKKRDAAHARMRAIYIDIINKRRKAGNAATGKPDMIENLMQCTYKNGQPLPDKEIAHIMITLLMAGQHSSSSIGSWIMLRLASQPAIVEELYQEQLANLERTANGSLPPLQFKDIENLPLHQNVIRETLRLHGSIHSLLRKVKNPLPVPGTPYIIPTSHVLLSAPGVTALSDEYFPNAMAWDPHRWETQAPEESKEDIVDYGYGAMSKGTSSPYLPFGAGRHRCIGEKFAYLNLTVIVATLVRHLRFHNLDGKKGVPGTDYTSLFSGPLKPTRVGWERRAAKSA", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Cyt_P450, Cyt_P450, Cyt_P450, Cyt_P450, Cyt_P450_E_grp-IV, Cyt_P450_E_grp-IV, Cyt_P450_E_grp-IV, Cyt_P450_E_grp-IV, Cyt_P450_E_grp-IV, Cyt_P450_E_grp-IV, Cyt_P450_E_grp-IV, Cyt_P450_E_grp-IV, Cyt_P450, CYP450_sterol_14alpha_dmase that shares evolutionary origin and functional similarity; 2. The protein should be classified within Cyt_P450_sf, Cyt_P450_sf sharing conserved structural features; 3. The protein should contain Cyt_P450_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MSILWIVAYALLAFAASIALNLVYQFLYRTFNKSRPPLVFHWVPFIGSTIHYGMDPYNFFFSCREKYGDIFTFILLGRPTTVYLGTQGNEFILNGKLKDVNAEEVYSPLTTPVFGSDVVYDCPNSKLIEQKKFIKFGLSQAALEAHVPLIEKEVIDYLAQSPNFNGTAGTVDIASAMAEITIFTAGSTLQGEEVRSKLTTEFAVLYHDLDKGFTPINFMLPWAPLPHNKKRDAAHARMRAIYIDIINKRRKAGNAATGKPDMIENLMQCTYKNGQPLPDKEIAHIMITLLMAGQHSSSSIGSWIMLRLASQPAIVEELYQEQLANLERTANGSLPPLQFKDIENLPLHQNVIRETLRLHGSIHSLLRKVKNPLPVPGTPYIIPTSHVLLSAPGVTALSDEYFPNAMAWDPHRWETQAPEESKEDIVDYGYGAMSKGTSSPYLPFGAGRHRCIGEKFAYLNLTVIVATLVRHLRFHNLDGKKGVPGTDYTSLFSGPLKPTRVGWERRAAKSA" }, { "InterPro": [ { "InterPro-ID": "IPR039444", "InterPro-Name": "SIR2-like", "InterPro-Type": "DOMAIN", "Beg": 128, "End": 269 }, { "InterPro-ID": "IPR029035", "InterPro-Name": "DHS-like_NAD/FAD-binding_dom", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 38, "End": 239 } ], "response#1": "MVKVDLESKRYGEKLKEVFLMLDNNVVECIKEITESSRNGKLVFFVGAGVSTLSDYPQWWRLVDKYHEELYGSPKKGNYSSDEYLRIPQIFYNVKGEMAFDGILKDFFQVDKPTNPIHDKILAMNPAHVITTNYDNLIDTACWKRGKYFSVISAEEDVANATSSRYLLKVHGDFRKGFKGENVVLKEDDYLNYDQNYPLISNLMKTIIATHTIVFIGYGLGDYNINMLLNWVRKLQKDSFHKPFFIRTDPSPIENETLIYYENKGLRIIDAASLIDSNEYDYLERYSAVMDLLIESQENKFITKDDEVIDYIYGKISPLFALQYIRKIDLKHVFEYDYHFEVNGTVVRHKNKGFGYMERFFELKESCDERSKLSKKQYERFNALFNFFEKNGVICMAKDAGTLNTSIEINSLAYHGKYDVMKKFIEEQSVSIEDDYKKAFFLACLGRWEESYDLYSNIILNSIDESNGCVYYLSQINRYRIYQSITQAVTQFNGLGLLTFGRHYKPFTDEFLARIEREMTNFNIDDLFNGMPFEFQKKYKILEFLSDNQFLYDDTVKLFELTNKVRSEMSEGSYSFGMSSDIVVLLRLYDNLRFLYENCLWSVSFHEFHQYIRNSMSLLIEKAEYERTRDIDELGFSFFGKKSGFFMEYYDFVNISRHFKIDDIKNLERSCSIDKIRFGEQEKIEEYLVGIAEEITKQFSANGMNVVFYTQFISEAKAALYFAKYVKLSEEGLGKIVKALLFYFPERDLDIGKRYVWLERLTKCNELPKSIISIIDDFLVLQAEKHIDQNYSEVSSNGLYSRDYGALIKHFEKNFISKRLSEITLCLTQDKQKQIDFLFKLLPLLSTNAKSHLLSFKSVENINDLMNGIRIGLIDEFTPEHEELIIEYLETRKVNYIVEKEKGIQTFSSNDYMSTFGIWYFLEEINNSKMEEFIGMDDQYDFFVDPENFDYKKFIPSWLKNYNDKLLGKIAGNKHMKHHVIEVLKERVKNSNDKRYLEILMNYFI", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more SIR2-like that are essential for its biological function; 2. The protein should be classified within DHS-like_NAD/FAD-binding_dom sharing conserved structural features. The designed protein sequence is ", "reference": "MVKVDLESKRYGEKLKEVFLMLDNNVVECIKEITESSRNGKLVFFVGAGVSTLSDYPQWWRLVDKYHEELYGSPKKGNYSSDEYLRIPQIFYNVKGEMAFDGILKDFFQVDKPTNPIHDKILAMNPAHVITTNYDNLIDTACWKRGKYFSVISAEEDVANATSSRYLLKVHGDFRKGFKGENVVLKEDDYLNYDQNYPLISNLMKTIIATHTIVFIGYGLGDYNINMLLNWVRKLQKDSFHKPFFIRTDPSPIENETLIYYENKGLRIIDAASLIDSNEYDYLERYSAVMDLLIESQENKFITKDDEVIDYIYGKISPLFALQYIRKIDLKHVFEYDYHFEVNGTVVRHKNKGFGYMERFFELKESCDERSKLSKKQYERFNALFNFFEKNGVICMAKDAGTLNTSIEINSLAYHGKYDVMKKFIEEQSVSIEDDYKKAFFLACLGRWEESYDLYSNIILNSIDESNGCVYYLSQINRYRIYQSITQAVTQFNGLGLLTFGRHYKPFTDEFLARIEREMTNFNIDDLFNGMPFEFQKKYKILEFLSDNQFLYDDTVKLFELTNKVRSEMSEGSYSFGMSSDIVVLLRLYDNLRFLYENCLWSVSFHEFHQYIRNSMSLLIEKAEYERTRDIDELGFSFFGKKSGFFMEYYDFVNISRHFKIDDIKNLERSCSIDKIRFGEQEKIEEYLVGIAEEITKQFSANGMNVVFYTQFISEAKAALYFAKYVKLSEEGLGKIVKALLFYFPERDLDIGKRYVWLERLTKCNELPKSIISIIDDFLVLQAEKHIDQNYSEVSSNGLYSRDYGALIKHFEKNFISKRLSEITLCLTQDKQKQIDFLFKLLPLLSTNAKSHLLSFKSVENINDLMNGIRIGLIDEFTPEHEELIIEYLETRKVNYIVEKEKGIQTFSSNDYMSTFGIWYFLEEINNSKMEEFIGMDDQYDFFVDPENFDYKKFIPSWLKNYNDKLLGKIAGNKHMKHHVIEVLKERVKNSNDKRYLEILMNYFI" }, { "InterPro": [ { "InterPro-ID": "IPR029058", "InterPro-Name": "AB_hydrolase_fold", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1, "End": 270 }, { "InterPro-ID": "IPR000073", "InterPro-Name": "AB_hydrolase_1", "InterPro-Type": "DOMAIN", "Beg": 19, "End": 252 }, { "InterPro-ID": "IPR029058", "InterPro-Name": "AB_hydrolase_fold", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 9, "End": 264 } ], "response#1": "MHQLKKLITVKVIGSGEKTVVLGHGFGTDQSVWKHLVPYLVEDYRVVLYDNMGAGPTNPDYFDFERYASLEGYAYDLLAILEELQIDSCIYLGHSLSSMTGVIASIFRPDLFSKLIMLSASPRFINADDYYGGFEKEDIDQLSQAMDTNYKSWIEGFAPLVIGGDMDSVAVQEFSRTLFNMRPDIALSVFRTIFTFDLRHFLCRVTVPCHIIQSSKDLAVPVAVSEYIHQNLGGKSIVEVISTEGHLPQLSAPEVTIPVLLRHISHDITSNAAP", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more AB_hydrolase_1 that are essential for its biological function; 2. The protein should be classified within AB_hydrolase_fold, AB_hydrolase_fold sharing conserved structural features. The designed protein sequence is ", "reference": "MHQLKKLITVKVIGSGEKTVVLGHGFGTDQSVWKHLVPYLVEDYRVVLYDNMGAGPTNPDYFDFERYASLEGYAYDLLAILEELQIDSCIYLGHSLSSMTGVIASIFRPDLFSKLIMLSASPRFINADDYYGGFEKEDIDQLSQAMDTNYKSWIEGFAPLVIGGDMDSVAVQEFSRTLFNMRPDIALSVFRTIFTFDLRHFLCRVTVPCHIIQSSKDLAVPVAVSEYIHQNLGGKSIVEVISTEGHLPQLSAPEVTIPVLLRHISHDITSNAAP" }, { "InterPro": [ { "InterPro-ID": "IPR027359", "InterPro-Name": "Volt_channel_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 732, "End": 843 }, { "InterPro-ID": "IPR050599", "InterPro-Name": "VDCC_alpha-1_subunit", "InterPro-Type": "FAMILY", "Beg": 727, "End": 2029 }, { "InterPro-ID": "IPR027359", "InterPro-Name": "Volt_channel_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 287, "End": 517 }, { "InterPro-ID": "IPR005821", "InterPro-Name": "Ion_trans_dom", "InterPro-Type": "DOMAIN", "Beg": 738, "End": 969 }, { "InterPro-ID": "IPR005821", "InterPro-Name": "Ion_trans_dom", "InterPro-Type": "DOMAIN", "Beg": 303, "End": 701 }, { "InterPro-ID": "IPR005821", "InterPro-Name": "Ion_trans_dom", "InterPro-Type": "DOMAIN", "Beg": 1499, "End": 1750 }, { "InterPro-ID": "IPR005821", "InterPro-Name": "Ion_trans_dom", "InterPro-Type": "DOMAIN", "Beg": 1166, "End": 1447 }, { "InterPro-ID": "IPR027359", "InterPro-Name": "Volt_channel_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1162, "End": 1289 }, { "InterPro-ID": "IPR027359", "InterPro-Name": "Volt_channel_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1491, "End": 1620 } ], "response#1": "MSHFRNHSLAISTSASIHTSASPSPVSPASPASASAGLSRRHSWNVTDESQEIPTFNDPSNASRHVDDNLTPRRAVPLHSTPLGKSGTVHSHRLSERDIIWADVNDGRDIGGDPNETTPTKSHNRPFFDSYQSTTSLHSTISPLDVNGRSSDDRERLTTGPSHVMHYNGIGKGTPRRSPRKPYNESGSSLRRSSTLRNVSQSLRKASVRVVNIMGTERGDGRERLGSDDEGEEVLQDVEIDGDQAFAMSSTNDNPGTVPSPRQLPTRSQREEVDHGRLRGRTMCLFGPMSRVRKSMDRLMRYPWTEPVILLLIITNVVVLAIQSAPALDSPRIDNGYFQGWEDFVLLVLFIVFTLEMFARIVVTGLLLDPETSLRESLFGQDGAVPILKQYLLITKFNIQSNLRRNATKRRAPWRSQGQNDAAHNKDSKTPANSALRSLTGLSEAPFQKAMARQKGLSDQGRPYLRHSWHRIDMIAVFAFWITFFLALTGYEATADRHVYIFRALSVLRAGRLLVITSGTTTILHSLKRAGPMLITVSYFLVFAACIFSIIGVQSFRGSFRRACVLTDPHNSSNVIQLETQCGGWLDPTSFKSMSYLSLDGTSSAVPPKGYICPLGQICMTTDENPNNNVNSFDNVFSSLVQVIIVISINTWAPVMYMAMDSDFFGSSLFFIAGVIVLNFWLINLLIAVVVNTFSDIRAETKRSAFGAGETFLGTEPHWAAEDEKTKNNRLLAFYQKTEIFWVILVVADLVAQGSKSSSSPESMLRLLDRLELAFTLAFDLEIIIRFLAYFPDWRTFFYRKRNCFDLFLAIACSIIQIPAISNSPIYPWLTVFQLIRWYRVILAFPRMKPLLITVFGSFSGLLNMVIFLFLMNFLGALMALQLFRGDLEAGETITFSQTYNSFLGMYQIFSSENWTDIVYDTMGAESQYKQNIIAAIFLCGWFLFSNFIVLQMFIAVINENFAIAEEQKRKQQIQAFIHRAEAPSAHASWIDRLNPYRLMTARHRAVRVKTLPPNLILPLKQNVGIDVSDVPSSLPMNDGKSTKGAVKRLLGRDGDEDQIPLKRFKRPPPRESTDDAEDEDDDRGLTDLLPPLNAAVSTDEHMDAFRERRNQQADFIAAHPSFDKSLWLFKQNNPIRKFCQACVPSAYGERIFGRSTNPTLALIVKTVVFLAVVASIVVAAIASPSYRREYYADHGISRRTWFDLTEVALGLIFVLEAAMKIVADGFIFAPNAYLLSLWNVLDFIILITLLINITTSLIFIGGLSRVTRALKSFRALRLITLFGRLRDTLHAVLFAGALKILDASIFMILYLIPFAVWGLNIFSGLLYYCNDDDSSGLTSCIGEFSTSSIDDSLTYLVPRVWVNPTVDESIWSFDSFRESILILFEIVSLEGWIDVMASVMNIVGRDQQPQNQASQWNAIYLVIFNLFGGVIILTLFVSIIIKNFSTRSGNALLTSEQRQWVDLSKFIKAQTPSQLPKGRPRLPFRAWCYDRAVNKNGFWAVGFTMIYYLHILLLMMEDFSENLLNEVQLDWIFLFLTVLYAVDLLVRFYGLGFKSFKSNGWNIFDLIVITGSFATTIPALQADSSGGTANQANVQLQKLFLVSISLKLVQRISSLNQLFKTSVASLPAIGNLFLLWATIFIFYAILYLEVFGLTKEGNNAGTRFQNYYTFGNALLMLAFMSTGEGWNGYMHDYTIQEPRCTENGNFLESDCGSAPGAYVLFISWNIISMYIFVNMFTGVVVESFAYVYQMPGKSSLNREEMRAFKQLWAEFDSQRIGYIKRKDLIRFFSRLTGVFEVRPFPVEFGVHNIIRHSRPDQVDNNASSQSYVITGVKHAVDVRRVAEQIAQIDYKQVRVRRQLFSRLYNEARISEEPGKGISFTAMLMMLAHYKLIDDESALQLDDLLLRRAKTERVTDLVNLDRVRGLLRTIYWRKRFLATRDARKLTLNAEAEGIPAIVLDPTPITPPDYNGQSRYDTPYSPQVQEKEESIPKRITPTEIIPPTSFSPSARTYPLPASDLSNSSDGNSLPSPSLYNSPTRLTSRPALLGRQPSNNSHLSSDDAHYRRDSRPDEDLHTKDYDDDMLDSMWGDMMREAVDQEGIKNEQG", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Ion_trans_dom, Ion_trans_dom, Ion_trans_dom, Ion_trans_dom that are essential for its biological function; 2. The protein should belong to VDCC_alpha-1_subunit that shares evolutionary origin and functional similarity; 3. The protein should be classified within Volt_channel_dom_sf, Volt_channel_dom_sf, Volt_channel_dom_sf, Volt_channel_dom_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MSHFRNHSLAISTSASIHTSASPSPVSPASPASASAGLSRRHSWNVTDESQEIPTFNDPSNASRHVDDNLTPRRAVPLHSTPLGKSGTVHSHRLSERDIIWADVNDGRDIGGDPNETTPTKSHNRPFFDSYQSTTSLHSTISPLDVNGRSSDDRERLTTGPSHVMHYNGIGKGTPRRSPRKPYNESGSSLRRSSTLRNVSQSLRKASVRVVNIMGTERGDGRERLGSDDEGEEVLQDVEIDGDQAFAMSSTNDNPGTVPSPRQLPTRSQREEVDHGRLRGRTMCLFGPMSRVRKSMDRLMRYPWTEPVILLLIITNVVVLAIQSAPALDSPRIDNGYFQGWEDFVLLVLFIVFTLEMFARIVVTGLLLDPETSLRESLFGQDGAVPILKQYLLITKFNIQSNLRRNATKRRAPWRSQGQNDAAHNKDSKTPANSALRSLTGLSEAPFQKAMARQKGLSDQGRPYLRHSWHRIDMIAVFAFWITFFLALTGYEATADRHVYIFRALSVLRAGRLLVITSGTTTILHSLKRAGPMLITVSYFLVFAACIFSIIGVQSFRGSFRRACVLTDPHNSSNVIQLETQCGGWLDPTSFKSMSYLSLDGTSSAVPPKGYICPLGQICMTTDENPNNNVNSFDNVFSSLVQVIIVISINTWAPVMYMAMDSDFFGSSLFFIAGVIVLNFWLINLLIAVVVNTFSDIRAETKRSAFGAGETFLGTEPHWAAEDEKTKNNRLLAFYQKTEIFWVILVVADLVAQGSKSSSSPESMLRLLDRLELAFTLAFDLEIIIRFLAYFPDWRTFFYRKRNCFDLFLAIACSIIQIPAISNSPIYPWLTVFQLIRWYRVILAFPRMKPLLITVFGSFSGLLNMVIFLFLMNFLGALMALQLFRGDLEAGETITFSQTYNSFLGMYQIFSSENWTDIVYDTMGAESQYKQNIIAAIFLCGWFLFSNFIVLQMFIAVINENFAIAEEQKRKQQIQAFIHRAEAPSAHASWIDRLNPYRLMTARHRAVRVKTLPPNLILPLKQNVGIDVSDVPSSLPMNDGKSTKGAVKRLLGRDGDEDQIPLKRFKRPPPRESTDDAEDEDDDRGLTDLLPPLNAAVSTDEHMDAFRERRNQQADFIAAHPSFDKSLWLFKQNNPIRKFCQACVPSAYGERIFGRSTNPTLALIVKTVVFLAVVASIVVAAIASPSYRREYYADHGISRRTWFDLTEVALGLIFVLEAAMKIVADGFIFAPNAYLLSLWNVLDFIILITLLINITTSLIFIGGLSRVTRALKSFRALRLITLFGRLRDTLHAVLFAGALKILDASIFMILYLIPFAVWGLNIFSGLLYYCNDDDSSGLTSCIGEFSTSSIDDSLTYLVPRVWVNPTVDESIWSFDSFRESILILFEIVSLEGWIDVMASVMNIVGRDQQPQNQASQWNAIYLVIFNLFGGVIILTLFVSIIIKNFSTRSGNALLTSEQRQWVDLSKFIKAQTPSQLPKGRPRLPFRAWCYDRAVNKNGFWAVGFTMIYYLHILLLMMEDFSENLLNEVQLDWIFLFLTVLYAVDLLVRFYGLGFKSFKSNGWNIFDLIVITGSFATTIPALQADSSGGTANQANVQLQKLFLVSISLKLVQRISSLNQLFKTSVASLPAIGNLFLLWATIFIFYAILYLEVFGLTKEGNNAGTRFQNYYTFGNALLMLAFMSTGEGWNGYMHDYTIQEPRCTENGNFLESDCGSAPGAYVLFISWNIISMYIFVNMFTGVVVESFAYVYQMPGKSSLNREEMRAFKQLWAEFDSQRIGYIKRKDLIRFFSRLTGVFEVRPFPVEFGVHNIIRHSRPDQVDNNASSQSYVITGVKHAVDVRRVAEQIAQIDYKQVRVRRQLFSRLYNEARISEEPGKGISFTAMLMMLAHYKLIDDESALQLDDLLLRRAKTERVTDLVNLDRVRGLLRTIYWRKRFLATRDARKLTLNAEAEGIPAIVLDPTPITPPDYNGQSRYDTPYSPQVQEKEESIPKRITPTEIIPPTSFSPSARTYPLPASDLSNSSDGNSLPSPSLYNSPTRLTSRPALLGRQPSNNSHLSSDDAHYRRDSRPDEDLHTKDYDDDMLDSMWGDMMREAVDQEGIKNEQG" }, { "InterPro": [ { "InterPro-ID": "IPR011989", "InterPro-Name": "ARM-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 18, "End": 339 }, { "InterPro-ID": "IPR003439", "InterPro-Name": "ABC_transporter-like_ATP-bd", "InterPro-Type": "DOMAIN", "Beg": 447, "End": 659 }, { "InterPro-ID": "IPR000953", "InterPro-Name": "Chromo/chromo_shadow_dom", "InterPro-Type": "DOMAIN", "Beg": 816, "End": 872 }, { "InterPro-ID": "IPR003593", "InterPro-Name": "AAA+_ATPase", "InterPro-Type": "DOMAIN", "Beg": 471, "End": 636 }, { "InterPro-ID": "IPR003593", "InterPro-Name": "AAA+_ATPase", "InterPro-Type": "DOMAIN", "Beg": 713, "End": 986 }, { "InterPro-ID": "IPR003439", "InterPro-Name": "ABC_transporter-like_ATP-bd", "InterPro-Type": "DOMAIN", "Beg": 705, "End": 936 }, { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 437, "End": 655 }, { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 683, "End": 987 }, { "InterPro-ID": "IPR017871", "InterPro-Name": "ABC_transporter-like_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 908, "End": 922 }, { "InterPro-ID": "IPR021133", "InterPro-Name": "HEAT_type_2", "InterPro-Type": "REPEAT", "Beg": 181, "End": 219 }, { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 664, "End": 980 }, { "InterPro-ID": "IPR050611", "InterPro-Name": "ABCF_EF3_subfamily", "InterPro-Type": "FAMILY", "Beg": 664, "End": 984 }, { "InterPro-ID": "IPR003439", "InterPro-Name": "ABC_transporter-like_ATP-bd", "InterPro-Type": "DOMAIN", "Beg": 687, "End": 1004 }, { "InterPro-ID": "IPR034085", "InterPro-Name": "TOG", "InterPro-Type": "DOMAIN", "Beg": 3, "End": 240 }, { "InterPro-ID": "IPR015688", "InterPro-Name": "eEF3_ABC2_chromodomain-like", "InterPro-Type": "DOMAIN", "Beg": 817, "End": 872 }, { "InterPro-ID": "IPR016024", "InterPro-Name": "ARM-type_fold", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 28, "End": 1050 }, { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 446, "End": 643 }, { "InterPro-ID": "IPR047038", "InterPro-Name": "eEF3_chromodomain-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 783, "End": 882 }, { "InterPro-ID": "IPR003439", "InterPro-Name": "ABC_transporter-like_ATP-bd", "InterPro-Type": "DOMAIN", "Beg": 462, "End": 590 }, { "InterPro-ID": "IPR017871", "InterPro-Name": "ABC_transporter-like_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 562, "End": 576 } ], "response#1": "MAPAATAAASSGKGSFDLATLFVADKAARDEAGLALADAVKKSGVEFFTQIGFNDAIVKALNDKKSQSAREGACEVISTLCENGAAQLLEPHVISSAENTPFPALLEAFADKVAAVKTAAIAAVKAIVQSMNPWASFVLLPALLNLIRTSGKWQIKAGSLEILQQLITSAPFQMGEAMPDLVPVLAEAVWDTKSDVKKAAKATLEKAVSLVENKDIEKFVPALVKSLLNPIEEVPKTISLLSATTFVSEVTAPTISLIAPLLIRGLDERPTATKRKVCVIADNMSKLVDSEYTVRPFLPQLLPRLIKTSETIADPEARSVANRAIVTLRRIGKVPAESDGSDLPPLPVAEGPHLATNFVALVKKHGGVSVEQTNPGLAYAGVLAASLVNHHNFDQKTWESTLPPYLKLALPSYDSLPAVRELLQKKADEAETDDAKFPDEEEGEDLCNIEQFNLAYGAKILLHHANMRLKRGHRYGLCGRNGSGKSTLMNAIINNQVEGFPPPTEVRTFYVQHDIDGSEAEISILDWVLGDKRLLATPDEIKSTLESVGFDEVKQKNSIGSLSGGWKMKLALARAILFKADILLLDEPTNHLDVLNVDWLINYLTSLTRCTSIIVSHDSDFLNRTVTDVLHLNNFKLKRYPGNLEDFVQHVPEAKSYYQLDVAEDYQFKLPNPPLLDGVKTKEKSLLKMRNVSFQYPGSSIQQLYDISLQVSLSSRVAILGPNGSGKSTLVKLLTGETEPNLGGQVWKHPNLVIGYVAQHAFHHIDNHLDSTPLEYMLWRYQTGEDLEEMHKANRVMTEAEIAKMKEGATVIKDGVKRIIDELVARKKLKQSYEYEVSFKGMSSAENIWISRDELVARGFEKKVMELDTREAQRLGLMRPLVRREIEKHFEDFGLDAEFVSHNSMRGLSGGQKVKVVLGAATWRRPHIICLDEPTNYLDRESLAALIAALKNFEGGVLIITHNREFSESICTEVWAMREGYLEASGHNWVEGQGSGERIDKKAADDDEVEYDALGNPIVKAKKEKKLSAADKRKAKKDRMARRKRGEEVFSDEEL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more ABC_transporter-like_ATP-bd, Chromo/chromo_shadow_dom, AAA+_ATPase, AAA+_ATPase, ABC_transporter-like_ATP-bd, ABC_transporter-like_ATP-bd, TOG, eEF3_ABC2_chromodomain-like, ABC_transporter-like_ATP-bd that are essential for its biological function; 2. The protein should belong to ABCF_EF3_subfamily that shares evolutionary origin and functional similarity; 3. The protein should be classified within ARM-like, P-loop_NTPase, P-loop_NTPase, P-loop_NTPase, ARM-type_fold, P-loop_NTPase, eEF3_chromodomain-like_sf sharing conserved structural features; 4. The protein should include one or more HEAT_type_2 that provide structural or functional support; 5. The protein should contain ABC_transporter-like_CS, ABC_transporter-like_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MAPAATAAASSGKGSFDLATLFVADKAARDEAGLALADAVKKSGVEFFTQIGFNDAIVKALNDKKSQSAREGACEVISTLCENGAAQLLEPHVISSAENTPFPALLEAFADKVAAVKTAAIAAVKAIVQSMNPWASFVLLPALLNLIRTSGKWQIKAGSLEILQQLITSAPFQMGEAMPDLVPVLAEAVWDTKSDVKKAAKATLEKAVSLVENKDIEKFVPALVKSLLNPIEEVPKTISLLSATTFVSEVTAPTISLIAPLLIRGLDERPTATKRKVCVIADNMSKLVDSEYTVRPFLPQLLPRLIKTSETIADPEARSVANRAIVTLRRIGKVPAESDGSDLPPLPVAEGPHLATNFVALVKKHGGVSVEQTNPGLAYAGVLAASLVNHHNFDQKTWESTLPPYLKLALPSYDSLPAVRELLQKKADEAETDDAKFPDEEEGEDLCNIEQFNLAYGAKILLHHANMRLKRGHRYGLCGRNGSGKSTLMNAIINNQVEGFPPPTEVRTFYVQHDIDGSEAEISILDWVLGDKRLLATPDEIKSTLESVGFDEVKQKNSIGSLSGGWKMKLALARAILFKADILLLDEPTNHLDVLNVDWLINYLTSLTRCTSIIVSHDSDFLNRTVTDVLHLNNFKLKRYPGNLEDFVQHVPEAKSYYQLDVAEDYQFKLPNPPLLDGVKTKEKSLLKMRNVSFQYPGSSIQQLYDISLQVSLSSRVAILGPNGSGKSTLVKLLTGETEPNLGGQVWKHPNLVIGYVAQHAFHHIDNHLDSTPLEYMLWRYQTGEDLEEMHKANRVMTEAEIAKMKEGATVIKDGVKRIIDELVARKKLKQSYEYEVSFKGMSSAENIWISRDELVARGFEKKVMELDTREAQRLGLMRPLVRREIEKHFEDFGLDAEFVSHNSMRGLSGGQKVKVVLGAATWRRPHIICLDEPTNYLDRESLAALIAALKNFEGGVLIITHNREFSESICTEVWAMREGYLEASGHNWVEGQGSGERIDKKAADDDEVEYDALGNPIVKAKKEKKLSAADKRKAKKDRMARRKRGEEVFSDEEL" }, { "InterPro": [ { "InterPro-ID": "IPR000485", "InterPro-Name": "AsnC-type_HTH_dom", "InterPro-Type": "DOMAIN", "Beg": 21, "End": 32 }, { "InterPro-ID": "IPR000485", "InterPro-Name": "AsnC-type_HTH_dom", "InterPro-Type": "DOMAIN", "Beg": 5, "End": 21 }, { "InterPro-ID": "IPR000485", "InterPro-Name": "AsnC-type_HTH_dom", "InterPro-Type": "DOMAIN", "Beg": 32, "End": 51 }, { "InterPro-ID": "IPR000485", "InterPro-Name": "AsnC-type_HTH_dom", "InterPro-Type": "DOMAIN", "Beg": 5, "End": 66 }, { "InterPro-ID": "IPR036388", "InterPro-Name": "WH-like_DNA-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1, "End": 58 }, { "InterPro-ID": "IPR019887", "InterPro-Name": "Tscrpt_reg_AsnC/Lrp_C", "InterPro-Type": "DOMAIN", "Beg": 77, "End": 141 }, { "InterPro-ID": "IPR036390", "InterPro-Name": "WH_DNA-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 4, "End": 65 }, { "InterPro-ID": "IPR019888", "InterPro-Name": "Tscrpt_reg_AsnC-like", "InterPro-Type": "FAMILY", "Beg": 5, "End": 112 }, { "InterPro-ID": "IPR011008", "InterPro-Name": "Dimeric_a/b-barrel", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 68, "End": 146 } ], "response#1": "MNEALDDIDRILVRELAADGRATLSELATRAGLSVSAVQSRVRRLESRGVVQGYSARINPEAVGHLLSAFVAITPLDPSQPDDAPARLEHIEEVESCYSVAGEESYVLLVRVASARALEDLLQRIRTTANVRTRSTIILNTFYSDRQHIP", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more AsnC-type_HTH_dom, AsnC-type_HTH_dom, AsnC-type_HTH_dom, AsnC-type_HTH_dom, Tscrpt_reg_AsnC/Lrp_C that are essential for its biological function; 2. The protein should belong to Tscrpt_reg_AsnC-like that shares evolutionary origin and functional similarity; 3. The protein should be classified within WH-like_DNA-bd_sf, WH_DNA-bd_sf, Dimeric_a/b-barrel sharing conserved structural features. The designed protein sequence is ", "reference": "MNEALDDIDRILVRELAADGRATLSELATRAGLSVSAVQSRVRRLESRGVVQGYSARINPEAVGHLLSAFVAITPLDPSQPDDAPARLEHIEEVESCYSVAGEESYVLLVRVASARALEDLLQRIRTTANVRTRSTIILNTFYSDRQHIP" }, { "InterPro": [ { "InterPro-ID": "IPR013766", "InterPro-Name": "Thioredoxin_domain", "InterPro-Type": "DOMAIN", "Beg": 4, "End": 171 }, { "InterPro-ID": "IPR037944", "InterPro-Name": "PRX5-like", "InterPro-Type": "FAMILY", "Beg": 2, "End": 164 }, { "InterPro-ID": "IPR037944", "InterPro-Name": "PRX5-like", "InterPro-Type": "FAMILY", "Beg": 7, "End": 163 }, { "InterPro-ID": "IPR013740", "InterPro-Name": "Redoxin", "InterPro-Type": "DOMAIN", "Beg": 6, "End": 163 }, { "InterPro-ID": "IPR036249", "InterPro-Name": "Thioredoxin-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1, "End": 166 } ], "response#1": "MAPLQPGDSFPANVVFSYIPPTGSLDLTVCGRPIEYNASEALAKGTSVLVAVPGAFTPTCQEKHVTGFIAKLDQLRQAGVDRVLFIASNDAFVMSAWGKANGIKDESILFLSDSDTAFSSSIGWANAGRTGRYAIVVKDGKVVYAAVDTVRGSTEKSGVDAVLTVLGNQGKL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Thioredoxin_domain, Redoxin that are essential for its biological function; 2. The protein should belong to PRX5-like, PRX5-like that shares evolutionary origin and functional similarity; 3. The protein should be classified within Thioredoxin-like_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MAPLQPGDSFPANVVFSYIPPTGSLDLTVCGRPIEYNASEALAKGTSVLVAVPGAFTPTCQEKHVTGFIAKLDQLRQAGVDRVLFIASNDAFVMSAWGKANGIKDESILFLSDSDTAFSSSIGWANAGRTGRYAIVVKDGKVVYAAVDTVRGSTEKSGVDAVLTVLGNQGKL" }, { "InterPro": [ { "InterPro-ID": "IPR050570", "InterPro-Name": "Cell_wall_metabolism_enzyme", "InterPro-Type": "FAMILY", "Beg": 19, "End": 390 }, { "InterPro-ID": "IPR016047", "InterPro-Name": "Peptidase_M23", "InterPro-Type": "DOMAIN", "Beg": 294, "End": 387 }, { "InterPro-ID": "IPR054512", "InterPro-Name": "NMB0315-like_N", "InterPro-Type": "DOMAIN", "Beg": 61, "End": 143 }, { "InterPro-ID": "IPR011055", "InterPro-Name": "Dup_hybrid_motif", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 141, "End": 388 }, { "InterPro-ID": "IPR011055", "InterPro-Name": "Dup_hybrid_motif", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 268, "End": 393 } ], "response#1": "MAVFPLSAKHRKYALRALAVSIILVSAAYIASTEGTERVRPQRVEQKLPPLSWGGSGVQTAYWVQEAVQPGDSLADVLARSGMARDEIARITEKYGGEADLRHLRADQSVHVLVGGDGSAREVQFFTDEDGERNLVALEKKGGIWRRSASDADMKVLPTLRSVVVKTSARGSLARAEVPVEIRESLSGIFAGRFSLDGLKEGDAVRLLYDSLYFHGQQVAAGDILAAEVVKGGTTHQAFYYRSDKEGGGGGNYYDEDGRVLQEKGGFNIEPLVYTRISSPFGYRMHPILHTWRLHTGIDYAAPQGTPVRASADGVITFKGRKGGYGNAVMIRHANGVETLYAHLSAFSQAQGNVRGGEVIGFVGSTGRSTGPHLHYEARINGQPVNPVSVALPTPELTQADKAAFAAQKQKADALLARLRGIPVTVSQSD", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Peptidase_M23, NMB0315-like_N that are essential for its biological function; 2. The protein should belong to Cell_wall_metabolism_enzyme that shares evolutionary origin and functional similarity; 3. The protein should be classified within Dup_hybrid_motif, Dup_hybrid_motif sharing conserved structural features. The designed protein sequence is ", "reference": "MAVFPLSAKHRKYALRALAVSIILVSAAYIASTEGTERVRPQRVEQKLPPLSWGGSGVQTAYWVQEAVQPGDSLADVLARSGMARDEIARITEKYGGEADLRHLRADQSVHVLVGGDGSAREVQFFTDEDGERNLVALEKKGGIWRRSASDADMKVLPTLRSVVVKTSARGSLARAEVPVEIRESLSGIFAGRFSLDGLKEGDAVRLLYDSLYFHGQQVAAGDILAAEVVKGGTTHQAFYYRSDKEGGGGGNYYDEDGRVLQEKGGFNIEPLVYTRISSPFGYRMHPILHTWRLHTGIDYAAPQGTPVRASADGVITFKGRKGGYGNAVMIRHANGVETLYAHLSAFSQAQGNVRGGEVIGFVGSTGRSTGPHLHYEARINGQPVNPVSVALPTPELTQADKAAFAAQKQKADALLARLRGIPVTVSQSD" }, { "InterPro": [ { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 281, "End": 448 }, { "InterPro-ID": "IPR007807", "InterPro-Name": "NAT10/TcmA_helicase", "InterPro-Type": "DOMAIN", "Beg": 285, "End": 458 }, { "InterPro-ID": "IPR032672", "InterPro-Name": "TmcA/NAT10/Kre33", "InterPro-Type": "FAMILY", "Beg": 20, "End": 610 }, { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 259, "End": 397 }, { "InterPro-ID": "IPR000182", "InterPro-Name": "GNAT_dom", "InterPro-Type": "DOMAIN", "Beg": 499, "End": 611 }, { "InterPro-ID": "IPR000182", "InterPro-Name": "GNAT_dom", "InterPro-Type": "DOMAIN", "Beg": 612, "End": 664 }, { "InterPro-ID": "IPR016181", "InterPro-Name": "Acyl_CoA_acyltransferase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 490, "End": 644 }, { "InterPro-ID": "IPR024914", "InterPro-Name": "tRNA_acetyltr_TmcA", "InterPro-Type": "FAMILY", "Beg": 36, "End": 806 }, { "InterPro-ID": "IPR000182", "InterPro-Name": "GNAT_dom", "InterPro-Type": "DOMAIN", "Beg": 474, "End": 663 }, { "InterPro-ID": "IPR013562", "InterPro-Name": "TmcA_N", "InterPro-Type": "DOMAIN", "Beg": 28, "End": 221 } ], "response#1": "MTVKVRFDKEVREYAKGEKVKDSVLKITETALAQALEKFHRRMIVIEGDTLKKAELAGILAGASARVLSDIVGELIEKRLRDESEDKIEVLYATDALGEETFGRKRYEAFRKHFDVLAGSEVNVTAVTFKHTREILGRTYDLLILDMSYDYSPNDLGRIIETVRGGGLIFILAHPFEKWKDMWTGFHKSLVTPPYTIEDVKKRFNRRLIRKFTQHDGIYIITESGKAKKKPKKSKSQAKIRARKGVEIPEETLFPKELYEMALTRGQVEVLKAFEELVDKEGMLVLTADRGRGKSVSVGIAAIGLAVALKKRTRIVVTAPELENVQSLFRFAKRALEKLGFKPYVVEEKGLIKELYARKIGLRYYPPAEGYKKNADLYILDEAAGIHVPILHKYLNKPRVVYSSTIHGYEGAGRGFSVKFLKKAREKRSFKELHMEEPIRYAYGDPIEKWLFDVLLLDAEPVELTEEDYELIKRKEVYLEEPDLDDWFENDREDLRHFVGIYILAHYRNRPSDVALLADAPHHEARVLRLKNGKIVTAVQIAKEGGIPKNVIDKMAKGYKPRGNIIPDMMVKHHYLKEFARLKGYRIVRIATHPDAMDMGLGSKALELLEKEAREKGLDWIGSGFGASEELVRFWVRNGFAVVHLSPARNPVSGEFTAIVLKPISKKAKELIKKANDEFRIRFTEWLGDTHRELEPEIARWLFETPFGEAVDYPIHLTEIQKKRLDAFTGKVLTYDTVVDAVKPIVKLYFLDGWMKPYLDERQIKLLIYRVLQAHSWEETAKLIDRTEMFTMIEVRDIIRGLWYYYKRLLT", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more NAT10/TcmA_helicase, GNAT_dom, GNAT_dom, GNAT_dom, TmcA_N that are essential for its biological function; 2. The protein should belong to TmcA/NAT10/Kre33, tRNA_acetyltr_TmcA that shares evolutionary origin and functional similarity; 3. The protein should be classified within P-loop_NTPase, P-loop_NTPase, Acyl_CoA_acyltransferase sharing conserved structural features. The designed protein sequence is ", "reference": "MTVKVRFDKEVREYAKGEKVKDSVLKITETALAQALEKFHRRMIVIEGDTLKKAELAGILAGASARVLSDIVGELIEKRLRDESEDKIEVLYATDALGEETFGRKRYEAFRKHFDVLAGSEVNVTAVTFKHTREILGRTYDLLILDMSYDYSPNDLGRIIETVRGGGLIFILAHPFEKWKDMWTGFHKSLVTPPYTIEDVKKRFNRRLIRKFTQHDGIYIITESGKAKKKPKKSKSQAKIRARKGVEIPEETLFPKELYEMALTRGQVEVLKAFEELVDKEGMLVLTADRGRGKSVSVGIAAIGLAVALKKRTRIVVTAPELENVQSLFRFAKRALEKLGFKPYVVEEKGLIKELYARKIGLRYYPPAEGYKKNADLYILDEAAGIHVPILHKYLNKPRVVYSSTIHGYEGAGRGFSVKFLKKAREKRSFKELHMEEPIRYAYGDPIEKWLFDVLLLDAEPVELTEEDYELIKRKEVYLEEPDLDDWFENDREDLRHFVGIYILAHYRNRPSDVALLADAPHHEARVLRLKNGKIVTAVQIAKEGGIPKNVIDKMAKGYKPRGNIIPDMMVKHHYLKEFARLKGYRIVRIATHPDAMDMGLGSKALELLEKEAREKGLDWIGSGFGASEELVRFWVRNGFAVVHLSPARNPVSGEFTAIVLKPISKKAKELIKKANDEFRIRFTEWLGDTHRELEPEIARWLFETPFGEAVDYPIHLTEIQKKRLDAFTGKVLTYDTVVDAVKPIVKLYFLDGWMKPYLDERQIKLLIYRVLQAHSWEETAKLIDRTEMFTMIEVRDIIRGLWYYYKRLLT" }, { "InterPro": [ { "InterPro-ID": "IPR051823", "InterPro-Name": "ASADH-related", "InterPro-Type": "FAMILY", "Beg": 6, "End": 364 }, { "InterPro-ID": "IPR000534", "InterPro-Name": "Semialdehyde_DH_NAD-bd", "InterPro-Type": "DOMAIN", "Beg": 8, "End": 136 }, { "InterPro-ID": "IPR036291", "InterPro-Name": "NAD(P)-bd_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 7, "End": 179 }, { "InterPro-ID": "IPR000319", "InterPro-Name": "Asp-semialdehyde_DH_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 242, "End": 256 }, { "InterPro-ID": "IPR005676", "InterPro-Name": "Asp_semi-ald_DH_pep-lack", "InterPro-Type": "FAMILY", "Beg": 7, "End": 359 }, { "InterPro-ID": "IPR000534", "InterPro-Name": "Semialdehyde_DH_NAD-bd", "InterPro-Type": "DOMAIN", "Beg": 8, "End": 134 }, { "InterPro-ID": "IPR012280", "InterPro-Name": "Semialdhyde_DH_dimer_dom", "InterPro-Type": "DOMAIN", "Beg": 165, "End": 344 } ], "response#1": "MSPRPQIKVGVLGATGTVGQRFIELLAAHPYFALHALGASSRSAGQQYARVVRWKLPSPIPDAVRHMVVHECRPDAPGFAECGVVFSGLDADVAGDIENAFRAADLVVYSNAKNYRRDPLCPLIVPLVNPSHLSIIPYQREQLGLKKGYIVTNANCSTTGIVVPLAALEKAFGPLDTVIVTTLQAISGAGYPGVSSLDIMDNVVPLISGEEDKIEWETNKILGGVTPDNKAFDLHAPKQINVSATCTRVPVIDGHTGCVSVKFARSPPPSVAEVENAFREYTCDAQHLGVPSAPAQAIVVHDAPDRPQPRLDKNLHNGACVSVGRIRECPVFDIKFVCLIDNVRLGAATSSIINAEIAVEKGLIQ", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Semialdehyde_DH_NAD-bd, Semialdehyde_DH_NAD-bd, Semialdhyde_DH_dimer_dom that are essential for its biological function; 2. The protein should belong to ASADH-related, Asp_semi-ald_DH_pep-lack that shares evolutionary origin and functional similarity; 3. The protein should be classified within NAD(P)-bd_dom_sf sharing conserved structural features; 4. The protein should contain Asp-semialdehyde_DH_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MSPRPQIKVGVLGATGTVGQRFIELLAAHPYFALHALGASSRSAGQQYARVVRWKLPSPIPDAVRHMVVHECRPDAPGFAECGVVFSGLDADVAGDIENAFRAADLVVYSNAKNYRRDPLCPLIVPLVNPSHLSIIPYQREQLGLKKGYIVTNANCSTTGIVVPLAALEKAFGPLDTVIVTTLQAISGAGYPGVSSLDIMDNVVPLISGEEDKIEWETNKILGGVTPDNKAFDLHAPKQINVSATCTRVPVIDGHTGCVSVKFARSPPPSVAEVENAFREYTCDAQHLGVPSAPAQAIVVHDAPDRPQPRLDKNLHNGACVSVGRIRECPVFDIKFVCLIDNVRLGAATSSIINAEIAVEKGLIQ" }, { "InterPro": [ { "InterPro-ID": "IPR006146", "InterPro-Name": "5'-Nucleotdase_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 119, "End": 130 }, { "InterPro-ID": "IPR029052", "InterPro-Name": "Metallo-depent_PP-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 33, "End": 350 }, { "InterPro-ID": "IPR006179", "InterPro-Name": "5_nucleotidase/apyrase", "InterPro-Type": "FAMILY", "Beg": 25, "End": 551 }, { "InterPro-ID": "IPR008334", "InterPro-Name": "5'-Nucleotdase_C", "InterPro-Type": "DOMAIN", "Beg": 353, "End": 513 }, { "InterPro-ID": "IPR004843", "InterPro-Name": "Calcineurin-like_PHP_ApaH", "InterPro-Type": "DOMAIN", "Beg": 37, "End": 256 }, { "InterPro-ID": "IPR029052", "InterPro-Name": "Metallo-depent_PP-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 32, "End": 349 }, { "InterPro-ID": "IPR036907", "InterPro-Name": "5'-Nucleotdase_C_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 352, "End": 542 }, { "InterPro-ID": "IPR036907", "InterPro-Name": "5'-Nucleotdase_C_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 353, "End": 552 }, { "InterPro-ID": "IPR006146", "InterPro-Name": "5'-Nucleotdase_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 36, "End": 48 }, { "InterPro-ID": "IPR006179", "InterPro-Name": "5_nucleotidase/apyrase", "InterPro-Type": "FAMILY", "Beg": 487, "End": 506 }, { "InterPro-ID": "IPR006179", "InterPro-Name": "5_nucleotidase/apyrase", "InterPro-Type": "FAMILY", "Beg": 34, "End": 52 }, { "InterPro-ID": "IPR006179", "InterPro-Name": "5_nucleotidase/apyrase", "InterPro-Type": "FAMILY", "Beg": 219, "End": 236 }, { "InterPro-ID": "IPR006179", "InterPro-Name": "5_nucleotidase/apyrase", "InterPro-Type": "FAMILY", "Beg": 239, "End": 262 }, { "InterPro-ID": "IPR006179", "InterPro-Name": "5_nucleotidase/apyrase", "InterPro-Type": "FAMILY", "Beg": 409, "End": 432 }, { "InterPro-ID": "IPR006179", "InterPro-Name": "5_nucleotidase/apyrase", "InterPro-Type": "FAMILY", "Beg": 290, "End": 310 } ], "response#1": "MALVRFATIITVLCHLAIQDGAAKSFPHGEKAPFPLTLIHINDLHARFDETNQKSSTCTNSKECIAGIARVYHTIKQLKSEYKTKNPLYLNAGDNFQGTLWYNLLRWNVTAYFIKELPPDAMTLGNHEFDHSPKGLAPYLAELEKMKIPTVVANLEKNGEPALKDSKIARSIVLKVGNRKVGVIGALYDKTHLVAQTGMVTLTNSIEAVRKEAQELKKKNVNIIVVLSHCGLDGDKQLAEEAGDLIDVIVGAHSHSLLLNKDAKVPYDTKYDTIEGDYPLVVKKSNNHTVLITQARSFGKYVGRLTVNFDCEGEVQSWEGYPIYMNNSVKQDEEVLRELEPWRAEVKRLGTQVIGTTEVFLDRESCRWCECTLGDLIADAYADQYTNSTVQPVAFVQAGNFRNPIEKGDITNGLAIEAAPYGSSVDMIKLSGADLWSAIDHSFTLDDEFRYNTAQVSGMAVVADLSKKPYERVQSIDIVGANGAKTALKKDQIYYVVVPSYLADGKDGFAMLKKGTNRVTGPLDSDVLIEYVRKRQTIAKTMFQEKRVVIENHTNGTCSWDLDSQRYKPK", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more 5'-Nucleotdase_C, Calcineurin-like_PHP_ApaH that are essential for its biological function; 2. The protein should belong to 5_nucleotidase/apyrase, 5_nucleotidase/apyrase, 5_nucleotidase/apyrase, 5_nucleotidase/apyrase, 5_nucleotidase/apyrase, 5_nucleotidase/apyrase, 5_nucleotidase/apyrase that shares evolutionary origin and functional similarity; 3. The protein should be classified within Metallo-depent_PP-like, Metallo-depent_PP-like, 5'-Nucleotdase_C_sf, 5'-Nucleotdase_C_sf sharing conserved structural features; 4. The protein should contain 5'-Nucleotdase_CS, 5'-Nucleotdase_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MALVRFATIITVLCHLAIQDGAAKSFPHGEKAPFPLTLIHINDLHARFDETNQKSSTCTNSKECIAGIARVYHTIKQLKSEYKTKNPLYLNAGDNFQGTLWYNLLRWNVTAYFIKELPPDAMTLGNHEFDHSPKGLAPYLAELEKMKIPTVVANLEKNGEPALKDSKIARSIVLKVGNRKVGVIGALYDKTHLVAQTGMVTLTNSIEAVRKEAQELKKKNVNIIVVLSHCGLDGDKQLAEEAGDLIDVIVGAHSHSLLLNKDAKVPYDTKYDTIEGDYPLVVKKSNNHTVLITQARSFGKYVGRLTVNFDCEGEVQSWEGYPIYMNNSVKQDEEVLRELEPWRAEVKRLGTQVIGTTEVFLDRESCRWCECTLGDLIADAYADQYTNSTVQPVAFVQAGNFRNPIEKGDITNGLAIEAAPYGSSVDMIKLSGADLWSAIDHSFTLDDEFRYNTAQVSGMAVVADLSKKPYERVQSIDIVGANGAKTALKKDQIYYVVVPSYLADGKDGFAMLKKGTNRVTGPLDSDVLIEYVRKRQTIAKTMFQEKRVVIENHTNGTCSWDLDSQRYKPK" }, { "InterPro": [ { "InterPro-ID": "IPR002350", "InterPro-Name": "Kazal_dom", "InterPro-Type": "DOMAIN", "Beg": 23, "End": 76 }, { "InterPro-ID": "IPR036058", "InterPro-Name": "Kazal_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 29, "End": 74 } ], "response#1": "MYSKYVIIISLLAVVSLGSAIEFWNPEECGCPPFDKTENEVCTKHGTTYDNRCQFDCHQKFLSKSGVALEEGPCILSAEAEEEAKK", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Kazal_dom that are essential for its biological function; 2. The protein should be classified within Kazal_dom_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MYSKYVIIISLLAVVSLGSAIEFWNPEECGCPPFDKTENEVCTKHGTTYDNRCQFDCHQKFLSKSGVALEEGPCILSAEAEEEAKK" }, { "InterPro": [ { "InterPro-ID": "IPR014795", "InterPro-Name": "TacA_1-like", "InterPro-Type": "FAMILY", "Beg": 2, "End": 95 }, { "InterPro-ID": "IPR014795", "InterPro-Name": "TacA_1-like", "InterPro-Type": "FAMILY", "Beg": 14, "End": 88 }, { "InterPro-ID": "IPR010985", "InterPro-Name": "Ribbon_hlx_hlx", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 9, "End": 87 } ], "response#1": "MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPNAALRKTMQTPAPWEQEK", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to TacA_1-like, TacA_1-like that shares evolutionary origin and functional similarity; 2. The protein should be classified within Ribbon_hlx_hlx sharing conserved structural features. The designed protein sequence is ", "reference": "MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPNAALRKTMQTPAPWEQEK" }, { "InterPro": [ { "InterPro-ID": "IPR002259", "InterPro-Name": "Eqnu_transpt", "InterPro-Type": "FAMILY", "Beg": 27, "End": 498 }, { "InterPro-ID": "IPR002259", "InterPro-Name": "Eqnu_transpt", "InterPro-Type": "FAMILY", "Beg": 146, "End": 498 }, { "InterPro-ID": "IPR036259", "InterPro-Name": "MFS_trans_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 99, "End": 492 } ], "response#1": "MTTSSDSAMVNHTPSPWYKFGFKSFAEFNTYVTFVFLGMSIMMVASAVTSAPDFLTRYYVYATGDPDAVAETPLFWNNANTFYNAGTYVLQVLTELFSLTPFMRRIPLSVRLFVGLGIPFAELLLIIIVPAATIKSQHGAIAVIMVVACVGGFSKALCDSCTNALVGPFPTKFMNGAQWGLTVIALLMSIIQIILKVSMGTSFHDILTMSRIYFGICIGIQLFAIFELAILRFNPFAQKYIAEYRAGAQRNAQNNESTLEETAPSMNEPAAGDIADLPATVDDKERALNEEEGDEVRAVTSEEFHVKRGAVLTATGDADKMVDLDQTGNITSTEQLLRASAASVFKRVYPMLVCVFLIYFTSLLTFPGVFFLVSTTSGWYMTVIVTLFNAGDFISRMVLMFRPLRPSPKVVVAGTLGRLIIIPFLVLCVRGIIRGEALPYVLITLLGLTNGYFGCMACIHCPRTTTLRYAGERSLAAMLSGISIMLGLCFGSNLSLAITLTH", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Eqnu_transpt, Eqnu_transpt that shares evolutionary origin and functional similarity; 2. The protein should be classified within MFS_trans_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MTTSSDSAMVNHTPSPWYKFGFKSFAEFNTYVTFVFLGMSIMMVASAVTSAPDFLTRYYVYATGDPDAVAETPLFWNNANTFYNAGTYVLQVLTELFSLTPFMRRIPLSVRLFVGLGIPFAELLLIIIVPAATIKSQHGAIAVIMVVACVGGFSKALCDSCTNALVGPFPTKFMNGAQWGLTVIALLMSIIQIILKVSMGTSFHDILTMSRIYFGICIGIQLFAIFELAILRFNPFAQKYIAEYRAGAQRNAQNNESTLEETAPSMNEPAAGDIADLPATVDDKERALNEEEGDEVRAVTSEEFHVKRGAVLTATGDADKMVDLDQTGNITSTEQLLRASAASVFKRVYPMLVCVFLIYFTSLLTFPGVFFLVSTTSGWYMTVIVTLFNAGDFISRMVLMFRPLRPSPKVVVAGTLGRLIIIPFLVLCVRGIIRGEALPYVLITLLGLTNGYFGCMACIHCPRTTTLRYAGERSLAAMLSGISIMLGLCFGSNLSLAITLTH" }, { "InterPro": [ { "InterPro-ID": "IPR037250", "InterPro-Name": "NEAT_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 363, "End": 495 }, { "InterPro-ID": "IPR037250", "InterPro-Name": "NEAT_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 969, "End": 1120 }, { "InterPro-ID": "IPR006635", "InterPro-Name": "NEAT_dom", "InterPro-Type": "DOMAIN", "Beg": 369, "End": 501 }, { "InterPro-ID": "IPR006635", "InterPro-Name": "NEAT_dom", "InterPro-Type": "DOMAIN", "Beg": 978, "End": 1128 }, { "InterPro-ID": "IPR001611", "InterPro-Name": "Leu-rich_rpt", "InterPro-Type": "REPEAT", "Beg": 617, "End": 638 }, { "InterPro-ID": "IPR011432", "InterPro-Name": "Shr-like_HID", "InterPro-Type": "DOMAIN", "Beg": 205, "End": 269 }, { "InterPro-ID": "IPR006635", "InterPro-Name": "NEAT_dom", "InterPro-Type": "DOMAIN", "Beg": 976, "End": 1129 }, { "InterPro-ID": "IPR006635", "InterPro-Name": "NEAT_dom", "InterPro-Type": "DOMAIN", "Beg": 976, "End": 1138 }, { "InterPro-ID": "IPR050333", "InterPro-Name": "SLRP", "InterPro-Type": "FAMILY", "Beg": 550, "End": 971 }, { "InterPro-ID": "IPR001611", "InterPro-Name": "Leu-rich_rpt", "InterPro-Type": "REPEAT", "Beg": 713, "End": 771 }, { "InterPro-ID": "IPR001611", "InterPro-Name": "Leu-rich_rpt", "InterPro-Type": "REPEAT", "Beg": 569, "End": 626 }, { "InterPro-ID": "IPR001611", "InterPro-Name": "Leu-rich_rpt", "InterPro-Type": "REPEAT", "Beg": 641, "End": 700 }, { "InterPro-ID": "IPR037250", "InterPro-Name": "NEAT_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 372, "End": 501 }, { "InterPro-ID": "IPR001611", "InterPro-Name": "Leu-rich_rpt", "InterPro-Type": "REPEAT", "Beg": 736, "End": 757 }, { "InterPro-ID": "IPR018247", "InterPro-Name": "EF_Hand_1_Ca_BS", "InterPro-Type": "BINDING_SITE", "Beg": 532, "End": 544 }, { "InterPro-ID": "IPR032675", "InterPro-Name": "LRR_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 496, "End": 818 }, { "InterPro-ID": "IPR003591", "InterPro-Name": "Leu-rich_rpt_typical-subtyp", "InterPro-Type": "REPEAT", "Beg": 734, "End": 757 }, { "InterPro-ID": "IPR003591", "InterPro-Name": "Leu-rich_rpt_typical-subtyp", "InterPro-Type": "REPEAT", "Beg": 760, "End": 781 }, { "InterPro-ID": "IPR003591", "InterPro-Name": "Leu-rich_rpt_typical-subtyp", "InterPro-Type": "REPEAT", "Beg": 663, "End": 686 }, { "InterPro-ID": "IPR003591", "InterPro-Name": "Leu-rich_rpt_typical-subtyp", "InterPro-Type": "REPEAT", "Beg": 710, "End": 733 }, { "InterPro-ID": "IPR003591", "InterPro-Name": "Leu-rich_rpt_typical-subtyp", "InterPro-Type": "REPEAT", "Beg": 568, "End": 590 }, { "InterPro-ID": "IPR003591", "InterPro-Name": "Leu-rich_rpt_typical-subtyp", "InterPro-Type": "REPEAT", "Beg": 639, "End": 662 }, { "InterPro-ID": "IPR003591", "InterPro-Name": "Leu-rich_rpt_typical-subtyp", "InterPro-Type": "REPEAT", "Beg": 591, "End": 614 }, { "InterPro-ID": "IPR003591", "InterPro-Name": "Leu-rich_rpt_typical-subtyp", "InterPro-Type": "REPEAT", "Beg": 687, "End": 709 }, { "InterPro-ID": "IPR003591", "InterPro-Name": "Leu-rich_rpt_typical-subtyp", "InterPro-Type": "REPEAT", "Beg": 616, "End": 638 }, { "InterPro-ID": "IPR006635", "InterPro-Name": "NEAT_dom", "InterPro-Type": "DOMAIN", "Beg": 371, "End": 497 }, { "InterPro-ID": "IPR001611", "InterPro-Name": "Leu-rich_rpt", "InterPro-Type": "REPEAT", "Beg": 569, "End": 590 }, { "InterPro-ID": "IPR001611", "InterPro-Name": "Leu-rich_rpt", "InterPro-Type": "REPEAT", "Beg": 641, "End": 662 }, { "InterPro-ID": "IPR006635", "InterPro-Name": "NEAT_dom", "InterPro-Type": "DOMAIN", "Beg": 368, "End": 495 } ], "response#1": "MKKISKCAFVAISALVLIQATQTVKSQEPLVQSQLVTTVALTQDNRLLVEEIGPYASQSAGKEYYKHIEKIIVDNDVYEKSLEGERTFDINYQGIKINADLIKDGKHELTIVNKKDGDILITFIKKGDKVTFISAQKLGTTDHQDSLKKDVLSDKTVPQNQGTQKVVKSGKNTANLSLITKLSQEDGAILFPEIDRYSDNKQIKALTQQITKVTVNGTVYKDLISDSVKDTNGWVSNMTGLHLGTKAFKDGENTIVISSKGFEDVTITVTKKDGQIHFVSAKQKQHVTAEDRQSTKLDVTTLEKAIKEADAIIAKESNKDAVKDLAEKLQVIKDSYKEIKDSKLLADTHRLLKDTIESYQAGEVSINNLTEGTYTLNFKANKENSEESSMLQGAFDKRAKLVVKADGTMEISMLNTALGQFLIDFSIESKGTYPAAVRKQVGQKDINGSYIRSEFTMPIDDLDKLHKGAVLVSAMGGQESDLNHYDKYTKLDMTFSKTVTKGWSGYQVETDDKEKGVGTERLEKVLVKLGKDLDGDGKLSKTELEQIRGELRLDHYELTDISLLKHAKNITELHLDGNQITEIPKELFSQMKQLRFLNLRSNHLTYLDKDTFKSNAQLRELYLSSNFIHSLEGGLFQSLHHLEQLDLSKNRIGRLCDNPFEGLSRLTSLGFAENSLEEIPEKALEPLTSLNFIDLSQNNLALLPKTIEKLRALSTIVASRNHITRIDNISFKNLPKLSVLDLSTNEISNLPNGIFKQNNQLTKLDFFNNLLTQVEESVFPDVETLNLDVKFNQIKSVSPKVRALIGQHKLTPQKHIAKLEASLDGEKIKYHQAFSLLDLYYWEQKTNSAIDKELVSVEEYQQLLQEKGSDTVSLLNDMQVDWSIVIQLQKKASNGQYVTVDEKLLSNDPKDDLTGEFSLKDPGTYRIRKALITKKFATQKEHIYLTSNDILVAKGPHSHQKDLVENGLRALNQKQLRDGIYYLNASMLKTDLASESMSNKAINHRVTLVVKKGVSYLEVEFRGIKVGKMLGYLGELSYFVDGYQRDLAGKPVGRTKKAEVVSYFTDVTGLPLADRYGKNYPKVLRMKLIEQAKKDGLVPLQVFVPIMDAISKGSGLQTVFMRLDWASLTTEKAKVVKETNNPQENSHLTSTDQLKGPQNRQQEKTPTSPPSAATGIANLTDLLAKKATGQSTQETSKTDDTDKAEKLKQLVRDHQTSIEGKTAKDTKTKKSDKKHRSNQQSNGEESSSRYHLIAGLSSFMIVALGFIIGRKTLFK", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more NEAT_dom, NEAT_dom, Shr-like_HID, NEAT_dom, NEAT_dom, NEAT_dom, NEAT_dom that are essential for its biological function; 2. The protein should belong to SLRP that shares evolutionary origin and functional similarity; 3. The protein should be classified within NEAT_dom_sf, NEAT_dom_sf, NEAT_dom_sf, LRR_dom_sf sharing conserved structural features; 4. The protein should include one or more Leu-rich_rpt, Leu-rich_rpt, Leu-rich_rpt, Leu-rich_rpt, Leu-rich_rpt, Leu-rich_rpt_typical-subtyp, Leu-rich_rpt_typical-subtyp, Leu-rich_rpt_typical-subtyp, Leu-rich_rpt_typical-subtyp, Leu-rich_rpt_typical-subtyp, Leu-rich_rpt_typical-subtyp, Leu-rich_rpt_typical-subtyp, Leu-rich_rpt_typical-subtyp, Leu-rich_rpt_typical-subtyp, Leu-rich_rpt, Leu-rich_rpt that provide structural or functional support; 5. The protein should include a EF_Hand_1_Ca_BS that enables ligand binding under diverse conditions. The designed protein sequence is ", "reference": "MKKISKCAFVAISALVLIQATQTVKSQEPLVQSQLVTTVALTQDNRLLVEEIGPYASQSAGKEYYKHIEKIIVDNDVYEKSLEGERTFDINYQGIKINADLIKDGKHELTIVNKKDGDILITFIKKGDKVTFISAQKLGTTDHQDSLKKDVLSDKTVPQNQGTQKVVKSGKNTANLSLITKLSQEDGAILFPEIDRYSDNKQIKALTQQITKVTVNGTVYKDLISDSVKDTNGWVSNMTGLHLGTKAFKDGENTIVISSKGFEDVTITVTKKDGQIHFVSAKQKQHVTAEDRQSTKLDVTTLEKAIKEADAIIAKESNKDAVKDLAEKLQVIKDSYKEIKDSKLLADTHRLLKDTIESYQAGEVSINNLTEGTYTLNFKANKENSEESSMLQGAFDKRAKLVVKADGTMEISMLNTALGQFLIDFSIESKGTYPAAVRKQVGQKDINGSYIRSEFTMPIDDLDKLHKGAVLVSAMGGQESDLNHYDKYTKLDMTFSKTVTKGWSGYQVETDDKEKGVGTERLEKVLVKLGKDLDGDGKLSKTELEQIRGELRLDHYELTDISLLKHAKNITELHLDGNQITEIPKELFSQMKQLRFLNLRSNHLTYLDKDTFKSNAQLRELYLSSNFIHSLEGGLFQSLHHLEQLDLSKNRIGRLCDNPFEGLSRLTSLGFAENSLEEIPEKALEPLTSLNFIDLSQNNLALLPKTIEKLRALSTIVASRNHITRIDNISFKNLPKLSVLDLSTNEISNLPNGIFKQNNQLTKLDFFNNLLTQVEESVFPDVETLNLDVKFNQIKSVSPKVRALIGQHKLTPQKHIAKLEASLDGEKIKYHQAFSLLDLYYWEQKTNSAIDKELVSVEEYQQLLQEKGSDTVSLLNDMQVDWSIVIQLQKKASNGQYVTVDEKLLSNDPKDDLTGEFSLKDPGTYRIRKALITKKFATQKEHIYLTSNDILVAKGPHSHQKDLVENGLRALNQKQLRDGIYYLNASMLKTDLASESMSNKAINHRVTLVVKKGVSYLEVEFRGIKVGKMLGYLGELSYFVDGYQRDLAGKPVGRTKKAEVVSYFTDVTGLPLADRYGKNYPKVLRMKLIEQAKKDGLVPLQVFVPIMDAISKGSGLQTVFMRLDWASLTTEKAKVVKETNNPQENSHLTSTDQLKGPQNRQQEKTPTSPPSAATGIANLTDLLAKKATGQSTQETSKTDDTDKAEKLKQLVRDHQTSIEGKTAKDTKTKKSDKKHRSNQQSNGEESSSRYHLIAGLSSFMIVALGFIIGRKTLFK" }, { "InterPro": [ { "InterPro-ID": "IPR029052", "InterPro-Name": "Metallo-depent_PP-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 30, "End": 341 }, { "InterPro-ID": "IPR006179", "InterPro-Name": "5_nucleotidase/apyrase", "InterPro-Type": "FAMILY", "Beg": 29, "End": 553 }, { "InterPro-ID": "IPR006146", "InterPro-Name": "5'-Nucleotdase_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 116, "End": 127 }, { "InterPro-ID": "IPR036907", "InterPro-Name": "5'-Nucleotdase_C_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 344, "End": 554 }, { "InterPro-ID": "IPR006146", "InterPro-Name": "5'-Nucleotdase_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 31, "End": 43 }, { "InterPro-ID": "IPR029052", "InterPro-Name": "Metallo-depent_PP-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 30, "End": 338 }, { "InterPro-ID": "IPR006179", "InterPro-Name": "5_nucleotidase/apyrase", "InterPro-Type": "FAMILY", "Beg": 409, "End": 432 }, { "InterPro-ID": "IPR006179", "InterPro-Name": "5_nucleotidase/apyrase", "InterPro-Type": "FAMILY", "Beg": 491, "End": 510 }, { "InterPro-ID": "IPR006179", "InterPro-Name": "5_nucleotidase/apyrase", "InterPro-Type": "FAMILY", "Beg": 29, "End": 47 }, { "InterPro-ID": "IPR006179", "InterPro-Name": "5_nucleotidase/apyrase", "InterPro-Type": "FAMILY", "Beg": 235, "End": 258 }, { "InterPro-ID": "IPR006179", "InterPro-Name": "5_nucleotidase/apyrase", "InterPro-Type": "FAMILY", "Beg": 281, "End": 301 }, { "InterPro-ID": "IPR006179", "InterPro-Name": "5_nucleotidase/apyrase", "InterPro-Type": "FAMILY", "Beg": 215, "End": 232 }, { "InterPro-ID": "IPR004843", "InterPro-Name": "Calcineurin-like_PHP_ApaH", "InterPro-Type": "DOMAIN", "Beg": 32, "End": 252 }, { "InterPro-ID": "IPR008334", "InterPro-Name": "5'-Nucleotdase_C", "InterPro-Type": "DOMAIN", "Beg": 344, "End": 517 } ], "response#1": "MKSLIGTLGLYCLFILTNNVVSSYGDDLYPLTIMHTNDFHARFEETNVKGNPCKSGEKCIGGLARVLHTIKKIIKEQEKKNIESLYINAGDNFQGTIWYNIGRWNVTSELMNIQPPDVMVLGNHEFDHGIDGLLPFLNNMDKTEIVVANMDARDEPQVAKKIKPFTIIKKKYRNIGVIGVVVEEVPDLANTGKLKFRNESEAILEAARNLKKEDPSVNIIIVVSHVGFDVDKIIAERTGSEVDIIVGGHSHTVLYTGTPPGPEKPEDNYPYVYNHPSGNKVLVVQAVCHAKYVGNLTVFFDKKGKVVTYEGAPIYMDTKVEQDKDVLEAMKPWRKLIDEKTKLVVGRTNVDLPRDICRSEECALGNLYTDSMIYAFGGKENCKSGSTWTTAPIAFVHAGAMRSSLHQGDILYSDALLLSPFTNMVVAYDLPGAQLKAALEFSAAPKNEDEKRRFLQMSGLKVTYNMSRAANNRIVDLKVRTNVCPYDQYENLDEKKTYRVVSPSFLQGGGDGFKMLRDYAKNIQNQKIDLDALVDYLKKFSPLAPKAEGRITIIH", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Calcineurin-like_PHP_ApaH, 5'-Nucleotdase_C that are essential for its biological function; 2. The protein should belong to 5_nucleotidase/apyrase, 5_nucleotidase/apyrase, 5_nucleotidase/apyrase, 5_nucleotidase/apyrase, 5_nucleotidase/apyrase, 5_nucleotidase/apyrase, 5_nucleotidase/apyrase that shares evolutionary origin and functional similarity; 3. The protein should be classified within Metallo-depent_PP-like, 5'-Nucleotdase_C_sf, Metallo-depent_PP-like sharing conserved structural features; 4. The protein should contain 5'-Nucleotdase_CS, 5'-Nucleotdase_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MKSLIGTLGLYCLFILTNNVVSSYGDDLYPLTIMHTNDFHARFEETNVKGNPCKSGEKCIGGLARVLHTIKKIIKEQEKKNIESLYINAGDNFQGTIWYNIGRWNVTSELMNIQPPDVMVLGNHEFDHGIDGLLPFLNNMDKTEIVVANMDARDEPQVAKKIKPFTIIKKKYRNIGVIGVVVEEVPDLANTGKLKFRNESEAILEAARNLKKEDPSVNIIIVVSHVGFDVDKIIAERTGSEVDIIVGGHSHTVLYTGTPPGPEKPEDNYPYVYNHPSGNKVLVVQAVCHAKYVGNLTVFFDKKGKVVTYEGAPIYMDTKVEQDKDVLEAMKPWRKLIDEKTKLVVGRTNVDLPRDICRSEECALGNLYTDSMIYAFGGKENCKSGSTWTTAPIAFVHAGAMRSSLHQGDILYSDALLLSPFTNMVVAYDLPGAQLKAALEFSAAPKNEDEKRRFLQMSGLKVTYNMSRAANNRIVDLKVRTNVCPYDQYENLDEKKTYRVVSPSFLQGGGDGFKMLRDYAKNIQNQKIDLDALVDYLKKFSPLAPKAEGRITIIH" }, { "InterPro": [ { "InterPro-ID": "IPR000182", "InterPro-Name": "GNAT_dom", "InterPro-Type": "DOMAIN", "Beg": 44, "End": 146 }, { "InterPro-ID": "IPR016181", "InterPro-Name": "Acyl_CoA_acyltransferase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 21, "End": 147 } ], "response#1": "MGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNMPDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLPQ", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more GNAT_dom that are essential for its biological function; 2. The protein should be classified within Acyl_CoA_acyltransferase sharing conserved structural features. The designed protein sequence is ", "reference": "MGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNMPDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLPQ" }, { "InterPro": [ { "InterPro-ID": "IPR010985", "InterPro-Name": "Ribbon_hlx_hlx", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 11, "End": 86 }, { "InterPro-ID": "IPR014795", "InterPro-Name": "TacA_1-like", "InterPro-Type": "FAMILY", "Beg": 2, "End": 94 }, { "InterPro-ID": "IPR014795", "InterPro-Name": "TacA_1-like", "InterPro-Type": "FAMILY", "Beg": 13, "End": 89 } ], "response#1": "MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADDPVIEKLLARKPQWDV", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to TacA_1-like, TacA_1-like that shares evolutionary origin and functional similarity; 2. The protein should be classified within Ribbon_hlx_hlx sharing conserved structural features. The designed protein sequence is ", "reference": "MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADDPVIEKLLARKPQWDV" }, { "InterPro": [ { "InterPro-ID": "IPR000719", "InterPro-Name": "Prot_kinase_dom", "InterPro-Type": "DOMAIN", "Beg": 812, "End": 989 }, { "InterPro-ID": "IPR010513", "InterPro-Name": "KEN_dom", "InterPro-Type": "DOMAIN", "Beg": 1108, "End": 1240 }, { "InterPro-ID": "IPR011009", "InterPro-Name": "Kinase-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 814, "End": 1116 }, { "InterPro-ID": "IPR010513", "InterPro-Name": "KEN_dom", "InterPro-Type": "DOMAIN", "Beg": 1111, "End": 1238 }, { "InterPro-ID": "IPR008271", "InterPro-Name": "Ser/Thr_kinase_AS", "InterPro-Type": "ACTIVE_SITE", "Beg": 927, "End": 939 }, { "InterPro-ID": "IPR000719", "InterPro-Name": "Prot_kinase_dom", "InterPro-Type": "DOMAIN", "Beg": 809, "End": 1105 }, { "InterPro-ID": "IPR045133", "InterPro-Name": "IRE1/2-like", "InterPro-Type": "FAMILY", "Beg": 334, "End": 1240 }, { "InterPro-ID": "IPR017441", "InterPro-Name": "Protein_kinase_ATP_BS", "InterPro-Type": "BINDING_SITE", "Beg": 815, "End": 837 }, { "InterPro-ID": "IPR015943", "InterPro-Name": "WD40/YVTN_repeat-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 151, "End": 427 }, { "InterPro-ID": "IPR011047", "InterPro-Name": "Quinoprotein_ADH-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 185, "End": 408 }, { "InterPro-ID": "IPR038357", "InterPro-Name": "KEN_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1109, "End": 1241 } ], "response#1": "MMRRPPSQGRWSASHQKLLLAFAFILIPWLQLADAQQQPQQPQIRIHSQRGDAPLDKVADDANTRWYATHAAPDVHPEAKFDTVNRKQKQQSTASPQQHQKYRRAPYDYASKDKAQNRYAQHPIRESEKPNYVKVPNDASALATLAPAQPVRAPHTSRHHWPSSSAASGLASPQNARSLEDWEVEDFVLLATVDGDLYASDRKTGRHLWHLEVDQPVVETKHYRTNNSVLDDDYRPVDHYIWAVEPSRDGGLYVWIPDSGAGLVRTGFTMKHLVEELAPYAGDEPPVVYTGDKKTTMVTLDAATGRVLKWFGSSGSQVNEAESCLRPNAFDDRDTTECSSMGTITLGRTEYTVGIQRRDGRPIATLKYAEWGPNTFDSDLYQQYHASLDNHYITSQHDGRIYAFDKSQAENDLPLYTHKFSSPVARVFDVCRPWDANAGSNPELVVLPQPPIPALDESTVKMRSNSIFLNQTESGDWYALSGRAYPLILDAPVAQISRDDLWDMAHAFDSINPNKLSKALVGTHFLNPVKSTGYHQPPTLPAGALDEYYEDLENASNNAHAVTNTVPEEPTIITKVKALPQSAANSVIDFVSNPILIIFLIGSLIYNEKKLRRSYHRFRTHGTIKDVYPFFVIESEAGDESGDDKDGVFPSSPSPRSQPQDQNAEDHLSRHKVERNAGDQDKVKDNRSLHDVSDTLEPSNKTVEKTADVVKQVDVAGPDAPSTDSNGAAPEKKKKAHRGRRGGVKHRKGRPTDGSQSHENDPALTTVDEAVSNAKKLGDRPSLEPDVMTIYNDMQAVTGSVISMGNIEVDTDVELGMGSNGTVVFAGRFDGRDVAVKRMTIQFYDIATRETKLLRESDDHPNVIRYYSQVQRGDFLYIALERCAASLADVIEKPYAFGELAKAGQKDLPGVLYQITNGISHLHSLRIVHRDLKPQNILVNLDKDGRPRLLVSDFGLCKKLEDRQSSFGATTGRAAGTSGWRAPELLLDDDGQNPAAIDSSTHSGSHTILVGDPNSLSNGGRATRAIDIFSLGLVFFYVLTNGSHPFDCGDRYMREVNIRKGNYNLDPLDALGDFAYEAKDLIASMLQASPKARPDSREVMAHPFFWSPKKRLAFLCDVSDSLEKEVRDPPSPALVELERHAPEVIKGDFLKVLTRDFVESLGKQRKYTGNKLLDLLRALRNKRNHYEDMSDSLKRSVGSLPDGYLAYWTVKFPMLLLTCWNVVYNLEWEKTDRFREYYEPAGL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Prot_kinase_dom, KEN_dom, KEN_dom, Prot_kinase_dom that are essential for its biological function; 2. The protein should belong to IRE1/2-like that shares evolutionary origin and functional similarity; 3. The protein should be classified within Kinase-like_dom_sf, WD40/YVTN_repeat-like_dom_sf, Quinoprotein_ADH-like_sf, KEN_sf sharing conserved structural features; 4. The protein must have Ser/Thr_kinase_AS that is conserved among related catalytic enzymes; 5. The protein should include a Protein_kinase_ATP_BS that enables ligand binding under diverse conditions. The designed protein sequence is ", "reference": "MMRRPPSQGRWSASHQKLLLAFAFILIPWLQLADAQQQPQQPQIRIHSQRGDAPLDKVADDANTRWYATHAAPDVHPEAKFDTVNRKQKQQSTASPQQHQKYRRAPYDYASKDKAQNRYAQHPIRESEKPNYVKVPNDASALATLAPAQPVRAPHTSRHHWPSSSAASGLASPQNARSLEDWEVEDFVLLATVDGDLYASDRKTGRHLWHLEVDQPVVETKHYRTNNSVLDDDYRPVDHYIWAVEPSRDGGLYVWIPDSGAGLVRTGFTMKHLVEELAPYAGDEPPVVYTGDKKTTMVTLDAATGRVLKWFGSSGSQVNEAESCLRPNAFDDRDTTECSSMGTITLGRTEYTVGIQRRDGRPIATLKYAEWGPNTFDSDLYQQYHASLDNHYITSQHDGRIYAFDKSQAENDLPLYTHKFSSPVARVFDVCRPWDANAGSNPELVVLPQPPIPALDESTVKMRSNSIFLNQTESGDWYALSGRAYPLILDAPVAQISRDDLWDMAHAFDSINPNKLSKALVGTHFLNPVKSTGYHQPPTLPAGALDEYYEDLENASNNAHAVTNTVPEEPTIITKVKALPQSAANSVIDFVSNPILIIFLIGSLIYNEKKLRRSYHRFRTHGTIKDVYPFFVIESEAGDESGDDKDGVFPSSPSPRSQPQDQNAEDHLSRHKVERNAGDQDKVKDNRSLHDVSDTLEPSNKTVEKTADVVKQVDVAGPDAPSTDSNGAAPEKKKKAHRGRRGGVKHRKGRPTDGSQSHENDPALTTVDEAVSNAKKLGDRPSLEPDVMTIYNDMQAVTGSVISMGNIEVDTDVELGMGSNGTVVFAGRFDGRDVAVKRMTIQFYDIATRETKLLRESDDHPNVIRYYSQVQRGDFLYIALERCAASLADVIEKPYAFGELAKAGQKDLPGVLYQITNGISHLHSLRIVHRDLKPQNILVNLDKDGRPRLLVSDFGLCKKLEDRQSSFGATTGRAAGTSGWRAPELLLDDDGQNPAAIDSSTHSGSHTILVGDPNSLSNGGRATRAIDIFSLGLVFFYVLTNGSHPFDCGDRYMREVNIRKGNYNLDPLDALGDFAYEAKDLIASMLQASPKARPDSREVMAHPFFWSPKKRLAFLCDVSDSLEKEVRDPPSPALVELERHAPEVIKGDFLKVLTRDFVESLGKQRKYTGNKLLDLLRALRNKRNHYEDMSDSLKRSVGSLPDGYLAYWTVKFPMLLLTCWNVVYNLEWEKTDRFREYYEPAGL" }, { "InterPro": [ { "InterPro-ID": "IPR012349", "InterPro-Name": "Split_barrel_FMN-bd", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 64, "End": 218 }, { "InterPro-ID": "IPR019595", "InterPro-Name": "DUF2470", "InterPro-Type": "DOMAIN", "Beg": 241, "End": 314 }, { "InterPro-ID": "IPR011576", "InterPro-Name": "Pyridox_Oxase_N", "InterPro-Type": "DOMAIN", "Beg": 85, "End": 210 }, { "InterPro-ID": "IPR037119", "InterPro-Name": "Haem_oxidase_HugZ-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 233, "End": 321 } ], "response#1": "MKSLVAHFSTPLITARLVPRCIIHRASISAVSFSTVRRRFSPLTMASAAQSSSQAVSYGSGNSDTDVFKLIQAHEEKAARLSPVEEIRTVLNGSICGMLSTFSQKYEGYPSGSMVDFACDADGSPILAVSSLAVHTKDLLANPKCSLLIARDPEDRTGLRITLHGDAVLVSEKDQAAVRSAYLAKHPKAFWVDFGDFSFMRIEPKVVRYVSGVATAFLGSGEFSKEEYQAAKVDPIAQYAKPVTSHMNKDHEEDTKAIVHNITSIPVESALMLDLDSLGFNVKATLQGNTFKLRVPFPRRAQDRKDVKTLIVEMLQAAKSN", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more DUF2470, Pyridox_Oxase_N that are essential for its biological function; 2. The protein should be classified within Split_barrel_FMN-bd, Haem_oxidase_HugZ-like_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MKSLVAHFSTPLITARLVPRCIIHRASISAVSFSTVRRRFSPLTMASAAQSSSQAVSYGSGNSDTDVFKLIQAHEEKAARLSPVEEIRTVLNGSICGMLSTFSQKYEGYPSGSMVDFACDADGSPILAVSSLAVHTKDLLANPKCSLLIARDPEDRTGLRITLHGDAVLVSEKDQAAVRSAYLAKHPKAFWVDFGDFSFMRIEPKVVRYVSGVATAFLGSGEFSKEEYQAAKVDPIAQYAKPVTSHMNKDHEEDTKAIVHNITSIPVESALMLDLDSLGFNVKATLQGNTFKLRVPFPRRAQDRKDVKTLIVEMLQAAKSN" }, { "InterPro": [ { "InterPro-ID": "IPR011008", "InterPro-Name": "Dimeric_a/b-barrel", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 149, "End": 241 }, { "InterPro-ID": "IPR049574", "InterPro-Name": "CrtA-like", "InterPro-Type": "FAMILY", "Beg": 35, "End": 254 } ], "response#1": "MTNELSNAAGASQQGPAASSFSADTPPRTTAGGDVLVLLLIDVAPAARLWGYGRFVAGTTPALGEPGARFAKQLGTGYEGGFGLRPSATRQGLFVLFEDEAAADAFIGRSELVQTYRRNARELCIVKARPYSARGSWDGQKLRVGSPAPVDGPVAALTRASIRPSQAHRFWPNAGPSQDSLERAAGCRLAVGLGEAPFLRQATFSVWDSVAAMDAYARTGAHQRAIVASRDFFSESMFVRFVPLSIEGVWKGRRYG", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to CrtA-like that shares evolutionary origin and functional similarity; 2. The protein should be classified within Dimeric_a/b-barrel sharing conserved structural features. The designed protein sequence is ", "reference": "MTNELSNAAGASQQGPAASSFSADTPPRTTAGGDVLVLLLIDVAPAARLWGYGRFVAGTTPALGEPGARFAKQLGTGYEGGFGLRPSATRQGLFVLFEDEAAADAFIGRSELVQTYRRNARELCIVKARPYSARGSWDGQKLRVGSPAPVDGPVAALTRASIRPSQAHRFWPNAGPSQDSLERAAGCRLAVGLGEAPFLRQATFSVWDSVAAMDAYARTGAHQRAIVASRDFFSESMFVRFVPLSIEGVWKGRRYG" }, { "InterPro": [ { "InterPro-ID": "IPR011527", "InterPro-Name": "ABC1_TM_dom", "InterPro-Type": "DOMAIN", "Beg": 790, "End": 1074 }, { "InterPro-ID": "IPR011527", "InterPro-Name": "ABC1_TM_dom", "InterPro-Type": "DOMAIN", "Beg": 57, "End": 305 }, { "InterPro-ID": "IPR003439", "InterPro-Name": "ABC_transporter-like_ATP-bd", "InterPro-Type": "DOMAIN", "Beg": 397, "End": 591 }, { "InterPro-ID": "IPR003439", "InterPro-Name": "ABC_transporter-like_ATP-bd", "InterPro-Type": "DOMAIN", "Beg": 1145, "End": 1209 }, { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 376, "End": 637 }, { "InterPro-ID": "IPR036640", "InterPro-Name": "ABC1_TM_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 763, "End": 1112 }, { "InterPro-ID": "IPR017871", "InterPro-Name": "ABC_transporter-like_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 563, "End": 577 }, { "InterPro-ID": "IPR039421", "InterPro-Name": "Type_1_exporter", "InterPro-Type": "FAMILY", "Beg": 6, "End": 637 }, { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1128, "End": 1400 }, { "InterPro-ID": "IPR036640", "InterPro-Name": "ABC1_TM_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 96, "End": 375 }, { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1137, "End": 1223 }, { "InterPro-ID": "IPR003439", "InterPro-Name": "ABC_transporter-like_ATP-bd", "InterPro-Type": "DOMAIN", "Beg": 378, "End": 662 }, { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1228, "End": 1417 }, { "InterPro-ID": "IPR003593", "InterPro-Name": "AAA+_ATPase", "InterPro-Type": "DOMAIN", "Beg": 405, "End": 639 }, { "InterPro-ID": "IPR003593", "InterPro-Name": "AAA+_ATPase", "InterPro-Type": "DOMAIN", "Beg": 1153, "End": 1388 }, { "InterPro-ID": "IPR003439", "InterPro-Name": "ABC_transporter-like_ATP-bd", "InterPro-Type": "DOMAIN", "Beg": 1228, "End": 1340 }, { "InterPro-ID": "IPR017871", "InterPro-Name": "ABC_transporter-like_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 1312, "End": 1326 }, { "InterPro-ID": "IPR036640", "InterPro-Name": "ABC1_TM_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 778, "End": 1096 }, { "InterPro-ID": "IPR011527", "InterPro-Name": "ABC1_TM_dom", "InterPro-Type": "DOMAIN", "Beg": 791, "End": 1083 }, { "InterPro-ID": "IPR011527", "InterPro-Name": "ABC1_TM_dom", "InterPro-Type": "DOMAIN", "Beg": 58, "End": 345 }, { "InterPro-ID": "IPR003439", "InterPro-Name": "ABC_transporter-like_ATP-bd", "InterPro-Type": "DOMAIN", "Beg": 1126, "End": 1416 }, { "InterPro-ID": "IPR036640", "InterPro-Name": "ABC1_TM_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 51, "End": 367 }, { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 377, "End": 635 } ], "response#1": "MGKEQKEKKDGNLSIKEEVEKELNKKSTAELFRKIKNEKISFFLPFKCLPAQHRKLLFISFVCAVLSGGTLPFFISVFGVILKNMNLGDDINPIILSLVSIGLVQFILSMISSYCMDVITSKILKTLKLEYLRSVFYQDGQFHDNNPGSKLRSDLDFYLEQVSSGIGTKFITIFTYASSFLGLYIWSLIKNARLTLCITCVFPLIYVCGVICNKKVKLNKKTSLLYNNNTMSIIEEALMGIRTVASYCGEKTILNKFNLSETFYSKYILKANFVEALHIGLINGLILVSYAFGFWYGTRIIINSATNQYPNNDFNGASVISILLGVLISMFMLTIILPNITEYMKALEATNSLYEIINRKPLVENNDDGETLPNIKKIEFKNVRFHYDTRKDVEIYKDLSFTLKEGKTYAFVGESGCGKSTILKLIERLYDPTEGDIIVNDSHNLKDINLKWWRSKIGVVSQDPLLFSNSIKNNIKYSLYSLKDLEAMENYYEENTNDTYENKNFSLISNSMTSNELLEMKKEYQTIKDSDVVDVSKKVLIHDFVSSLPDKYDTLVGSNASKLSGGQKQRISIARAIMRNPKILILDEATSSLDNKSEYLVQKTINNLKGNENRITIIIAHRLSTIRYANTIFVLSNRERSDNNNNNNNDDNNNNNNNNNNKINNEGSYIIEQGTHDSLMKNKNGIYHLMINNQKISSNKSSNNGNDNGSDNKSSAYKDSDTGNDADNMNSLSIHENENISNNRNCKNTAENEKEEKVPFFKRMFRRKKKAPNNLRIIYKEIFSYKKDVTIIFFSILVAGGLYPVFALLYARYVSTLFDFANLEYNSNKYSIYILLIAIAMFISETLKNYYNNKIGEKVEKTMKRRLFENILYQEMSFFDQDKNTPGVLSAHINRDVHLLKTGLVNNIVIFSHFIMLFLVSMVMSFYFCPIVAAVLTFIYFINMRVFAVRARLTKSKEIEKKENMSSGVFAFSSDDEMFKDPSFLIQEAFYNMHTVINYGLEDYFCNLIEKAIDYKNKGQKRRIIVNAALWGFSQSAQLFINSFAYWFGSFLIKRGTILVDDFMKSLFTFIFTGSYAGKLMSLKGDSENAKLSFEKYYPLMIRKSNIDVRDDGGIRINKNLIKGKVDIKDVNFRYISRPNVPIYKNLSFTCDSKKTTAIVGETGSGKSTFMNLLLRFYDLKNDHIILKNDMTNFQDYQNNNNNSLVLKNVNEFSNQSGSAEDYTVFNNNGEILLDDINICDYNLRDLRNLFSIVSQEPMLFNMSIYENIKFGREDATLEDVKRVSKFAAIDEFIESLPNKYDTNVGPYGKSLSGGQKQRIAIARALLREPKILLLDEATSSLDSNSEKLIEKTIVDIKDKADKTIITIAHRIASIKRSDKIVVFNNPDRNGTFVQSHGTHDELLSAQDGIYKKYVKLAK", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more ABC1_TM_dom, ABC1_TM_dom, ABC_transporter-like_ATP-bd, ABC_transporter-like_ATP-bd, ABC_transporter-like_ATP-bd, AAA+_ATPase, AAA+_ATPase, ABC_transporter-like_ATP-bd, ABC1_TM_dom, ABC1_TM_dom, ABC_transporter-like_ATP-bd that are essential for its biological function; 2. The protein should belong to Type_1_exporter that shares evolutionary origin and functional similarity; 3. The protein should be classified within P-loop_NTPase, ABC1_TM_sf, P-loop_NTPase, ABC1_TM_sf, P-loop_NTPase, P-loop_NTPase, ABC1_TM_sf, ABC1_TM_sf, P-loop_NTPase sharing conserved structural features; 4. The protein should contain ABC_transporter-like_CS, ABC_transporter-like_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MGKEQKEKKDGNLSIKEEVEKELNKKSTAELFRKIKNEKISFFLPFKCLPAQHRKLLFISFVCAVLSGGTLPFFISVFGVILKNMNLGDDINPIILSLVSIGLVQFILSMISSYCMDVITSKILKTLKLEYLRSVFYQDGQFHDNNPGSKLRSDLDFYLEQVSSGIGTKFITIFTYASSFLGLYIWSLIKNARLTLCITCVFPLIYVCGVICNKKVKLNKKTSLLYNNNTMSIIEEALMGIRTVASYCGEKTILNKFNLSETFYSKYILKANFVEALHIGLINGLILVSYAFGFWYGTRIIINSATNQYPNNDFNGASVISILLGVLISMFMLTIILPNITEYMKALEATNSLYEIINRKPLVENNDDGETLPNIKKIEFKNVRFHYDTRKDVEIYKDLSFTLKEGKTYAFVGESGCGKSTILKLIERLYDPTEGDIIVNDSHNLKDINLKWWRSKIGVVSQDPLLFSNSIKNNIKYSLYSLKDLEAMENYYEENTNDTYENKNFSLISNSMTSNELLEMKKEYQTIKDSDVVDVSKKVLIHDFVSSLPDKYDTLVGSNASKLSGGQKQRISIARAIMRNPKILILDEATSSLDNKSEYLVQKTINNLKGNENRITIIIAHRLSTIRYANTIFVLSNRERSDNNNNNNNDDNNNNNNNNNNKINNEGSYIIEQGTHDSLMKNKNGIYHLMINNQKISSNKSSNNGNDNGSDNKSSAYKDSDTGNDADNMNSLSIHENENISNNRNCKNTAENEKEEKVPFFKRMFRRKKKAPNNLRIIYKEIFSYKKDVTIIFFSILVAGGLYPVFALLYARYVSTLFDFANLEYNSNKYSIYILLIAIAMFISETLKNYYNNKIGEKVEKTMKRRLFENILYQEMSFFDQDKNTPGVLSAHINRDVHLLKTGLVNNIVIFSHFIMLFLVSMVMSFYFCPIVAAVLTFIYFINMRVFAVRARLTKSKEIEKKENMSSGVFAFSSDDEMFKDPSFLIQEAFYNMHTVINYGLEDYFCNLIEKAIDYKNKGQKRRIIVNAALWGFSQSAQLFINSFAYWFGSFLIKRGTILVDDFMKSLFTFIFTGSYAGKLMSLKGDSENAKLSFEKYYPLMIRKSNIDVRDDGGIRINKNLIKGKVDIKDVNFRYISRPNVPIYKNLSFTCDSKKTTAIVGETGSGKSTFMNLLLRFYDLKNDHIILKNDMTNFQDYQNNNNNSLVLKNVNEFSNQSGSAEDYTVFNNNGEILLDDINICDYNLRDLRNLFSIVSQEPMLFNMSIYENIKFGREDATLEDVKRVSKFAAIDEFIESLPNKYDTNVGPYGKSLSGGQKQRIAIARALLREPKILLLDEATSSLDSNSEKLIEKTIVDIKDKADKTIITIAHRIASIKRSDKIVVFNNPDRNGTFVQSHGTHDELLSAQDGIYKKYVKLAK" }, { "InterPro": [ { "InterPro-ID": "IPR036396", "InterPro-Name": "Cyt_P450_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1, "End": 406 }, { "InterPro-ID": "IPR036396", "InterPro-Name": "Cyt_P450_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 43, "End": 403 }, { "InterPro-ID": "IPR002397", "InterPro-Name": "Cyt_P450_B", "InterPro-Type": "FAMILY", "Beg": 198, "End": 220 }, { "InterPro-ID": "IPR002397", "InterPro-Name": "Cyt_P450_B", "InterPro-Type": "FAMILY", "Beg": 324, "End": 339 }, { "InterPro-ID": "IPR002397", "InterPro-Name": "Cyt_P450_B", "InterPro-Type": "FAMILY", "Beg": 346, "End": 355 }, { "InterPro-ID": "IPR002397", "InterPro-Name": "Cyt_P450_B", "InterPro-Type": "FAMILY", "Beg": 355, "End": 366 }, { "InterPro-ID": "IPR002397", "InterPro-Name": "Cyt_P450_B", "InterPro-Type": "FAMILY", "Beg": 93, "End": 104 }, { "InterPro-ID": "IPR002397", "InterPro-Name": "Cyt_P450_B", "InterPro-Type": "FAMILY", "Beg": 278, "End": 289 }, { "InterPro-ID": "IPR002397", "InterPro-Name": "Cyt_P450_B", "InterPro-Type": "FAMILY", "Beg": 296, "End": 323 }, { "InterPro-ID": "IPR002397", "InterPro-Name": "Cyt_P450_B", "InterPro-Type": "FAMILY", "Beg": 138, "End": 154 }, { "InterPro-ID": "IPR002397", "InterPro-Name": "Cyt_P450_B", "InterPro-Type": "FAMILY", "Beg": 155, "End": 170 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 194, "End": 371 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 243, "End": 260 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 346, "End": 355 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 278, "End": 289 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 355, "End": 366 }, { "InterPro-ID": "IPR017972", "InterPro-Name": "Cyt_P450_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 348, "End": 357 } ], "response#1": "MSTTAHTEPSWADLPFLDFTDPNFSWDSPEVAEAREKSWIARTPLALLVLRYAEADQLARDKRLISGFRGLVDMVGTPEGPVRDFMVDFLQSLDGADHRRLRGLATHPFTPRRITAVQPFVRSTVEQLIDKLPQGDFDFVQHFPHPLPALVMCQLLGFPLEDYDTVGRLSIETNLGLALSNDQDILVKVEQGLGRMFDYLVAAIEKRKVEPGDDLTSDIVRAFHDGVLDDYELRTLVATVLVAGYETTNHQLALAMYDFAQHPDQWMKIKENPELAPQAVEEVLRWSPTLPVTATRVAAEDFEVNGVRIPTGTPVFMCAHVAHRDPRVFADADRFDITVKREAPSIAFGGGPHFCLGTALARLELTEAVAALATRLDPPQIAGEITWRHELGVAGPDALPLRFGAA", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Cyt_P450_B, Cyt_P450_B, Cyt_P450_B, Cyt_P450_B, Cyt_P450_B, Cyt_P450_B, Cyt_P450_B, Cyt_P450_B, Cyt_P450_B, Cyt_P450, Cyt_P450, Cyt_P450, Cyt_P450, Cyt_P450 that shares evolutionary origin and functional similarity; 2. The protein should be classified within Cyt_P450_sf, Cyt_P450_sf sharing conserved structural features; 3. The protein should contain Cyt_P450_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MSTTAHTEPSWADLPFLDFTDPNFSWDSPEVAEAREKSWIARTPLALLVLRYAEADQLARDKRLISGFRGLVDMVGTPEGPVRDFMVDFLQSLDGADHRRLRGLATHPFTPRRITAVQPFVRSTVEQLIDKLPQGDFDFVQHFPHPLPALVMCQLLGFPLEDYDTVGRLSIETNLGLALSNDQDILVKVEQGLGRMFDYLVAAIEKRKVEPGDDLTSDIVRAFHDGVLDDYELRTLVATVLVAGYETTNHQLALAMYDFAQHPDQWMKIKENPELAPQAVEEVLRWSPTLPVTATRVAAEDFEVNGVRIPTGTPVFMCAHVAHRDPRVFADADRFDITVKREAPSIAFGGGPHFCLGTALARLELTEAVAALATRLDPPQIAGEITWRHELGVAGPDALPLRFGAA" }, { "InterPro": [ { "InterPro-ID": "IPR012338", "InterPro-Name": "Beta-lactam/transpept-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 20, "End": 265 }, { "InterPro-ID": "IPR012338", "InterPro-Name": "Beta-lactam/transpept-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 30, "End": 259 }, { "InterPro-ID": "IPR001460", "InterPro-Name": "PCN-bd_Tpept", "InterPro-Type": "DOMAIN", "Beg": 48, "End": 259 }, { "InterPro-ID": "IPR002137", "InterPro-Name": "Beta-lactam_class-D_AS", "InterPro-Type": "ACTIVE_SITE", "Beg": 68, "End": 78 }, { "InterPro-ID": "IPR050515", "InterPro-Name": "Bact_Transpept/Beta-Lactamase", "InterPro-Type": "FAMILY", "Beg": 52, "End": 147 } ], "response#1": "MRVLALSAVFLVASIIGMPAVAKEWQENKSWNAHFTEHKSQGVVVLWNENKQQGFTNNLKRANQAFLPASTFKIPNSLIALDLGVVKDEHQVFKWDGQTRDIATWNRDHNLITAMKYSVVPVYQEFARQIGEARMSKMLHAFDYGNEDISGNVDSFWLDGGIRISATEQISFLRKLYHNKLHVSERSQRIVKQAMLTEANGDYIIRAKTGYSTRIEPKIGWWVGWVELDDNVWFFAMNMDMPTSDGLGLRQAITKEVLKQEKIIP", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more PCN-bd_Tpept that are essential for its biological function; 2. The protein should belong to Bact_Transpept/Beta-Lactamase that shares evolutionary origin and functional similarity; 3. The protein should be classified within Beta-lactam/transpept-like, Beta-lactam/transpept-like sharing conserved structural features; 4. The protein must have Beta-lactam_class-D_AS that is conserved among related catalytic enzymes. The designed protein sequence is ", "reference": "MRVLALSAVFLVASIIGMPAVAKEWQENKSWNAHFTEHKSQGVVVLWNENKQQGFTNNLKRANQAFLPASTFKIPNSLIALDLGVVKDEHQVFKWDGQTRDIATWNRDHNLITAMKYSVVPVYQEFARQIGEARMSKMLHAFDYGNEDISGNVDSFWLDGGIRISATEQISFLRKLYHNKLHVSERSQRIVKQAMLTEANGDYIIRAKTGYSTRIEPKIGWWVGWVELDDNVWFFAMNMDMPTSDGLGLRQAITKEVLKQEKIIP" }, { "InterPro": [ { "InterPro-ID": "IPR036250", "InterPro-Name": "AcylCo_DH-like_C", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 514, "End": 619 }, { "InterPro-ID": "IPR013786", "InterPro-Name": "AcylCoA_DH/ox_N", "InterPro-Type": "DOMAIN", "Beg": 119, "End": 193 }, { "InterPro-ID": "IPR049448", "InterPro-Name": "ACAD9/ACADV-like_C", "InterPro-Type": "DOMAIN", "Beg": 510, "End": 629 }, { "InterPro-ID": "IPR009075", "InterPro-Name": "AcylCo_DH/oxidase_C", "InterPro-Type": "DOMAIN", "Beg": 312, "End": 439 }, { "InterPro-ID": "IPR046373", "InterPro-Name": "Acyl-CoA_Oxase/DH_mid-dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 196, "End": 309 }, { "InterPro-ID": "IPR006091", "InterPro-Name": "Acyl-CoA_Oxase/DH_mid-dom", "InterPro-Type": "DOMAIN", "Beg": 212, "End": 298 }, { "InterPro-ID": "IPR009100", "InterPro-Name": "AcylCoA_DH/oxidase_NM_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 119, "End": 316 }, { "InterPro-ID": "IPR036250", "InterPro-Name": "AcylCo_DH-like_C", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 312, "End": 456 }, { "InterPro-ID": "IPR037069", "InterPro-Name": "AcylCoA_DH/ox_N_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 102, "End": 195 } ], "response#1": "MRPNLFSGASRLLTYSRNGKLLTRGRSTKATSSSLDSQHQDAATTEGGRAESVEESPEQQRKLPTREPLAKNFFIGVVDKELLAYPEVIPRDEMAQLENSLLPLKNYFVEPRETEETSPETLRQLGLYGLNVSTDYEGKGYGWSASLMASEPDSTDINVTLGLQTHRVVVDLLKEVGTPLQQQRYLQDLATGKLIGTEAIYEISPPEEDYFNTTAELFPEYGKWQLNGEKSFVICTPGERQLFLVLAQTQQPNVPGVLGRGTTIFLVDSQQEGVRLGEKHATFGCRKAEIRRVHFEGVKLGEDQVVGLPHDGNRYSEQLVRSSRLRGSLVGLSLAKKLLNELAQYTVNTTQCGVQLQDLELTRIHMSRAMCSVYAMESMLYLTAGLLDEFRAQDVTLESAITKYFTLRQVYAIASQNLGVVGPKSLLSGETTELGLRDAAQLCTQGESLDTLGMFIALTGLQHAGQAMNTGVRKSRNPLFNPGHIFGKFLDNNSIDNPKTKMQLSEHVHPSLEAAAQCIELSVARLQMAVELMFTKHGNAVVERQSEMQRLAEVGTLIYAMWASVARASRSYCIGLPLADHELLTATAICSEGRDRVRTLCTEIYGGHFVNNDNNLVRLSKQVAKSKGYFAVHPLTFNF", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more AcylCoA_DH/ox_N, ACAD9/ACADV-like_C, AcylCo_DH/oxidase_C, Acyl-CoA_Oxase/DH_mid-dom that are essential for its biological function; 2. The protein should be classified within AcylCo_DH-like_C, Acyl-CoA_Oxase/DH_mid-dom_sf, AcylCoA_DH/oxidase_NM_dom_sf, AcylCo_DH-like_C, AcylCoA_DH/ox_N_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MRPNLFSGASRLLTYSRNGKLLTRGRSTKATSSSLDSQHQDAATTEGGRAESVEESPEQQRKLPTREPLAKNFFIGVVDKELLAYPEVIPRDEMAQLENSLLPLKNYFVEPRETEETSPETLRQLGLYGLNVSTDYEGKGYGWSASLMASEPDSTDINVTLGLQTHRVVVDLLKEVGTPLQQQRYLQDLATGKLIGTEAIYEISPPEEDYFNTTAELFPEYGKWQLNGEKSFVICTPGERQLFLVLAQTQQPNVPGVLGRGTTIFLVDSQQEGVRLGEKHATFGCRKAEIRRVHFEGVKLGEDQVVGLPHDGNRYSEQLVRSSRLRGSLVGLSLAKKLLNELAQYTVNTTQCGVQLQDLELTRIHMSRAMCSVYAMESMLYLTAGLLDEFRAQDVTLESAITKYFTLRQVYAIASQNLGVVGPKSLLSGETTELGLRDAAQLCTQGESLDTLGMFIALTGLQHAGQAMNTGVRKSRNPLFNPGHIFGKFLDNNSIDNPKTKMQLSEHVHPSLEAAAQCIELSVARLQMAVELMFTKHGNAVVERQSEMQRLAEVGTLIYAMWASVARASRSYCIGLPLADHELLTATAICSEGRDRVRTLCTEIYGGHFVNNDNNLVRLSKQVAKSKGYFAVHPLTFNF" }, { "InterPro": [ { "InterPro-ID": "IPR036291", "InterPro-Name": "NAD(P)-bd_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 5, "End": 337 }, { "InterPro-ID": "IPR001509", "InterPro-Name": "Epimerase_deHydtase", "InterPro-Type": "DOMAIN", "Beg": 19, "End": 264 } ], "response#1": "MMSRYEELRKELPAQPKVWLITGVAGFIGSNLLETLLKLDQKVVGLDNFATGHQRNLDEVRSLVSEKQWSNFKFIQGDIRNLDDCNNACAGVDYVLHQAALGSVPRSINDPITSNATNIDGFLNMLIAARDAKVQSFTYAASSSTYGDHPGLPKVEDTIGKPLSPYAVTKYVNELYADVFSRCYGFSTIGLRYFNVFGRRQDPNGAYAAVIPKWTSSMIQGDDVYINGDGETSRDFCYIENTVQANLLAATAGLDARNQVYNIAVGGRTSLNQLFFALRDGLAENGVSYHREPVYRDFREGDVRHSLADISKAAKLLGYAPKYDVSAGVALAMPWYIMFLK", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Epimerase_deHydtase that are essential for its biological function; 2. The protein should be classified within NAD(P)-bd_dom_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MMSRYEELRKELPAQPKVWLITGVAGFIGSNLLETLLKLDQKVVGLDNFATGHQRNLDEVRSLVSEKQWSNFKFIQGDIRNLDDCNNACAGVDYVLHQAALGSVPRSINDPITSNATNIDGFLNMLIAARDAKVQSFTYAASSSTYGDHPGLPKVEDTIGKPLSPYAVTKYVNELYADVFSRCYGFSTIGLRYFNVFGRRQDPNGAYAAVIPKWTSSMIQGDDVYINGDGETSRDFCYIENTVQANLLAATAGLDARNQVYNIAVGGRTSLNQLFFALRDGLAENGVSYHREPVYRDFREGDVRHSLADISKAAKLLGYAPKYDVSAGVALAMPWYIMFLK" }, { "InterPro": [ { "InterPro-ID": "IPR014026", "InterPro-Name": "UDP-Glc/GDP-Man_DH_dimer", "InterPro-Type": "DOMAIN", "Beg": 200, "End": 288 }, { "InterPro-ID": "IPR028359", "InterPro-Name": "UDP_ManNAc/GlcNAc_DH", "InterPro-Type": "FAMILY", "Beg": 1, "End": 422 }, { "InterPro-ID": "IPR028359", "InterPro-Name": "UDP_ManNAc/GlcNAc_DH", "InterPro-Type": "FAMILY", "Beg": 3, "End": 416 }, { "InterPro-ID": "IPR014027", "InterPro-Name": "UDP-Glc/GDP-Man_DH_C", "InterPro-Type": "DOMAIN", "Beg": 316, "End": 414 }, { "InterPro-ID": "IPR017476", "InterPro-Name": "UDP-Glc/GDP-Man", "InterPro-Type": "FAMILY", "Beg": 5, "End": 408 }, { "InterPro-ID": "IPR036291", "InterPro-Name": "NAD(P)-bd_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 5, "End": 189 }, { "InterPro-ID": "IPR036220", "InterPro-Name": "UDP-Glc/GDP-Man_DH_C_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 298, "End": 415 }, { "InterPro-ID": "IPR014027", "InterPro-Name": "UDP-Glc/GDP-Man_DH_C", "InterPro-Type": "DOMAIN", "Beg": 315, "End": 415 }, { "InterPro-ID": "IPR001732", "InterPro-Name": "UDP-Glc/GDP-Man_DH_N", "InterPro-Type": "DOMAIN", "Beg": 5, "End": 178 }, { "InterPro-ID": "IPR017476", "InterPro-Name": "UDP-Glc/GDP-Man", "InterPro-Type": "FAMILY", "Beg": 4, "End": 420 }, { "InterPro-ID": "IPR008927", "InterPro-Name": "6-PGluconate_DH-like_C_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 199, "End": 289 } ], "response#1": "MKDLKVAVVGLGYVGLPLAVEFGKKRTVVGFDINQGRIAELRQGIDSTLEVDAAELKEASELSFTFNLQDLQKCNVFIVTVPTPIDEHKQPDLTPLVKASESIGKVLKKGDIVIYESTVYPGATEEDCVPVLEKFSGLRFNEDFFAGYSPERINPGDKEHRVSSIKKVTSGSTPEIAELVDSLYREIITAGTHKASSIKVAEAAKVIENTQRDLNIALINELAIIFNRMGIDTEAVLKAAGTKWNFMPFRPGLVGGHCIGVDPYYLTHKAQSIGYHPEIILAGRRLNDGMGAYVVSQLVKAMLKRRIHVDGARVLLMGLTFKENCPDLRNTKVVDIVRELAEYNIQVDVFDPWVSAEDAMHEYGITPVGTPSHGAYDGIILAVAHSEFKNMGAENIRKLGKAEHVLYDLKYLLDEDKSDLRL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more UDP-Glc/GDP-Man_DH_dimer, UDP-Glc/GDP-Man_DH_C, UDP-Glc/GDP-Man_DH_C, UDP-Glc/GDP-Man_DH_N that are essential for its biological function; 2. The protein should belong to UDP_ManNAc/GlcNAc_DH, UDP_ManNAc/GlcNAc_DH, UDP-Glc/GDP-Man, UDP-Glc/GDP-Man that shares evolutionary origin and functional similarity; 3. The protein should be classified within NAD(P)-bd_dom_sf, UDP-Glc/GDP-Man_DH_C_sf, 6-PGluconate_DH-like_C_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MKDLKVAVVGLGYVGLPLAVEFGKKRTVVGFDINQGRIAELRQGIDSTLEVDAAELKEASELSFTFNLQDLQKCNVFIVTVPTPIDEHKQPDLTPLVKASESIGKVLKKGDIVIYESTVYPGATEEDCVPVLEKFSGLRFNEDFFAGYSPERINPGDKEHRVSSIKKVTSGSTPEIAELVDSLYREIITAGTHKASSIKVAEAAKVIENTQRDLNIALINELAIIFNRMGIDTEAVLKAAGTKWNFMPFRPGLVGGHCIGVDPYYLTHKAQSIGYHPEIILAGRRLNDGMGAYVVSQLVKAMLKRRIHVDGARVLLMGLTFKENCPDLRNTKVVDIVRELAEYNIQVDVFDPWVSAEDAMHEYGITPVGTPSHGAYDGIILAVAHSEFKNMGAENIRKLGKAEHVLYDLKYLLDEDKSDLRL" }, { "InterPro": [ { "InterPro-ID": "IPR055274", "InterPro-Name": "SWO1", "InterPro-Type": "FAMILY", "Beg": 1, "End": 663 }, { "InterPro-ID": "IPR014002", "InterPro-Name": "Agenet_dom_plant", "InterPro-Type": "DOMAIN", "Beg": 1571, "End": 1635 }, { "InterPro-ID": "IPR014002", "InterPro-Name": "Agenet_dom_plant", "InterPro-Type": "DOMAIN", "Beg": 1662, "End": 1720 }, { "InterPro-ID": "IPR008395", "InterPro-Name": "Agenet-like_dom", "InterPro-Type": "DOMAIN", "Beg": 1576, "End": 1640 } ], "response#1": "MDYDDSDFQNQNLHLAGEANNKFPPVLQPYALPKFDFDDTLNTHLRFDSLGESEAFLGIEGNEDNNWIEDFSRGSSGIVFSSGATESCAISRHNNVWSEATSSESVAMLLNSVGQDEVIVREDTIKKSDTSHELGCTMETVEPGQTSHERSLSKEETVNLQPNPSVDDTPGESSVVKTDDGQEQVLVKDDSPTAVEEASVEEKNSILTSNTATVEAIDTTDLGKIGTETTDNLLDQTEEKANVESRMEDDCSDGNVQTIITCSGELNNQSTLLPETSNDENVISDHIQSSYNRNDLTADARSILVEGHSDSHIDSASEVEKVEAENIGKTAKPDLKEIELSDVTVLERGDQAPSTLEVGGQDVSGTECQDLLVSTVHTSVAVEASLELAGELTTITNSVSIEKPELLSHQHMEVITSEHESTFQIETETYPQIHVFETSESVYISTMDSMVEAREGGVSKKSDNEGSARTSNLEQSMELPVNANDRDQDVKNSQILSESVVSGSVGYVSGGSTSELAESESQSDSIPTDKSETMIDSSLNLEELQPLSQDGAPAVSLTSSIDLHMVKTSSDDSDQGSYSETKKVYGEPENGQTVPPVDASCSGSQMDQEARKRAEGTKQSTYSVEGCPRSEGSKDAVDADGVGQVLQQQSEELIFEENVVTEAVKAPETLSVLDKDNKNEMPITSSLPILGSEAGKDGQEEDNTAASGGIMAAGTPVTHPKGDAIVLGDSRASTCSESSVKSYVTAIEDAATNLKTPLDSFPTVKTSELQFNNTETNSVKKPEDQNISGFMSAGSPVLNRNETSSSEMNLTPDQLKAGKISKAVIFSQATLVSPIVVGSPSTSSLDKTAAKSSKAKSERKPRRTSKSVGKETSRKGTSVKGATPIEQFQSGGKTNAVNQSLASHIQITQSTEKQRSLQSPALKAFGSLSTPTASLPDLNSSALSSILRRPFTDLQQVQLRAQIFVYGALIQGTAPDEAYMISAFGGADGGKGSWEKSWRTCVVRAQKSLVATPETPLQSRPGKTETPSAGHTNSKESSGTNPMIPLSSPLWSLSTSVDTLQSSSVQRGSAATHQPLLSASHAHQTPPTQNIVGHNTPWMSPLPFRNAWLASQQTSGFDVGSRFPVYPITDPVKLTPMKESSMTLSGAKHVQSGTSSNVSKVTPTLEPTSTVVAPAQHSTRVKSRKRKKMPVSVESGPNILNSLKQTELAASPLVPFTPTPANLGYNAGTLPSVVSMTAVPMDLVSTFPGKKIKSSFPSPIFGGNLVREVKQRSVLSEDTIEKLKEAKMHAEDASALATAAVSHSEYVWKQIEQQSHAGLQPETQDRLASAAVAIAAAAAVAKAAAAAANVAANAALQAKLMAEEASLPNASDQGLPKSYDSILPGQGTPASILKGEGAVVNSSSVLIAAREASKKRVEAATAATKRAENMDSIVKAAELASEAVSQAGILVSMGHPPLLNKLVEAGPSNYWRQAQESQEVQPCKTVVLEKETVSTSEGTFAGPKIVQTEFGGSVNTADGVSGPVPATGKLKGQEGDKYADLAKNNDVVFEPEVGSKFSIDAQQTIKATKNEDIKEGSNVEVFKEEPGLRTAWYSANVLSLEDDKAYVLFSDLSVEQGTDKLKEWVALKGEGDQAPKIRPARSVTALPYEGTRKRRRAALGDHIWKIGDRVDSWVHDSWLEGVITEKNKKDENTVTVHFPAEEETLTIKAWNLRPSLVWKDGKWIECSSSGETISSSHEGDTPKEKRPRLGTPALVAEVKDTSMKIVDDPDLGKPPQTGVLNLGVSENTFNIGKSTREENKPDPLRMKRTGLQKQGSKVIFGVPKPGKKRKFMDVSKHYVSEASTKTQERKEPVKPVRSIVPQNSGIGSWKMPSKTISIEKQTTISRPKTFKPAPKPKEKPGATARIIPRKDSRNTTASDMESDESAENRGPGSGVSFKGTVEEQTTSSSHDTGSKNSSSLSTNKGRVAPTAGRLAKIEEDKALAENSSKTSEGMEPRRSIRRIQPTSRLLEGLQTSMMTSKIPSVSHSKSHLSQSKK", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Agenet_dom_plant, Agenet_dom_plant, Agenet-like_dom that are essential for its biological function; 2. The protein should belong to SWO1 that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MDYDDSDFQNQNLHLAGEANNKFPPVLQPYALPKFDFDDTLNTHLRFDSLGESEAFLGIEGNEDNNWIEDFSRGSSGIVFSSGATESCAISRHNNVWSEATSSESVAMLLNSVGQDEVIVREDTIKKSDTSHELGCTMETVEPGQTSHERSLSKEETVNLQPNPSVDDTPGESSVVKTDDGQEQVLVKDDSPTAVEEASVEEKNSILTSNTATVEAIDTTDLGKIGTETTDNLLDQTEEKANVESRMEDDCSDGNVQTIITCSGELNNQSTLLPETSNDENVISDHIQSSYNRNDLTADARSILVEGHSDSHIDSASEVEKVEAENIGKTAKPDLKEIELSDVTVLERGDQAPSTLEVGGQDVSGTECQDLLVSTVHTSVAVEASLELAGELTTITNSVSIEKPELLSHQHMEVITSEHESTFQIETETYPQIHVFETSESVYISTMDSMVEAREGGVSKKSDNEGSARTSNLEQSMELPVNANDRDQDVKNSQILSESVVSGSVGYVSGGSTSELAESESQSDSIPTDKSETMIDSSLNLEELQPLSQDGAPAVSLTSSIDLHMVKTSSDDSDQGSYSETKKVYGEPENGQTVPPVDASCSGSQMDQEARKRAEGTKQSTYSVEGCPRSEGSKDAVDADGVGQVLQQQSEELIFEENVVTEAVKAPETLSVLDKDNKNEMPITSSLPILGSEAGKDGQEEDNTAASGGIMAAGTPVTHPKGDAIVLGDSRASTCSESSVKSYVTAIEDAATNLKTPLDSFPTVKTSELQFNNTETNSVKKPEDQNISGFMSAGSPVLNRNETSSSEMNLTPDQLKAGKISKAVIFSQATLVSPIVVGSPSTSSLDKTAAKSSKAKSERKPRRTSKSVGKETSRKGTSVKGATPIEQFQSGGKTNAVNQSLASHIQITQSTEKQRSLQSPALKAFGSLSTPTASLPDLNSSALSSILRRPFTDLQQVQLRAQIFVYGALIQGTAPDEAYMISAFGGADGGKGSWEKSWRTCVVRAQKSLVATPETPLQSRPGKTETPSAGHTNSKESSGTNPMIPLSSPLWSLSTSVDTLQSSSVQRGSAATHQPLLSASHAHQTPPTQNIVGHNTPWMSPLPFRNAWLASQQTSGFDVGSRFPVYPITDPVKLTPMKESSMTLSGAKHVQSGTSSNVSKVTPTLEPTSTVVAPAQHSTRVKSRKRKKMPVSVESGPNILNSLKQTELAASPLVPFTPTPANLGYNAGTLPSVVSMTAVPMDLVSTFPGKKIKSSFPSPIFGGNLVREVKQRSVLSEDTIEKLKEAKMHAEDASALATAAVSHSEYVWKQIEQQSHAGLQPETQDRLASAAVAIAAAAAVAKAAAAAANVAANAALQAKLMAEEASLPNASDQGLPKSYDSILPGQGTPASILKGEGAVVNSSSVLIAAREASKKRVEAATAATKRAENMDSIVKAAELASEAVSQAGILVSMGHPPLLNKLVEAGPSNYWRQAQESQEVQPCKTVVLEKETVSTSEGTFAGPKIVQTEFGGSVNTADGVSGPVPATGKLKGQEGDKYADLAKNNDVVFEPEVGSKFSIDAQQTIKATKNEDIKEGSNVEVFKEEPGLRTAWYSANVLSLEDDKAYVLFSDLSVEQGTDKLKEWVALKGEGDQAPKIRPARSVTALPYEGTRKRRRAALGDHIWKIGDRVDSWVHDSWLEGVITEKNKKDENTVTVHFPAEEETLTIKAWNLRPSLVWKDGKWIECSSSGETISSSHEGDTPKEKRPRLGTPALVAEVKDTSMKIVDDPDLGKPPQTGVLNLGVSENTFNIGKSTREENKPDPLRMKRTGLQKQGSKVIFGVPKPGKKRKFMDVSKHYVSEASTKTQERKEPVKPVRSIVPQNSGIGSWKMPSKTISIEKQTTISRPKTFKPAPKPKEKPGATARIIPRKDSRNTTASDMESDESAENRGPGSGVSFKGTVEEQTTSSSHDTGSKNSSSLSTNKGRVAPTAGRLAKIEEDKALAENSSKTSEGMEPRRSIRRIQPTSRLLEGLQTSMMTSKIPSVSHSKSHLSQSKK" }, { "InterPro": [ { "InterPro-ID": "IPR004269", "InterPro-Name": "Folate_rcpt", "InterPro-Type": "FAMILY", "Beg": 12, "End": 229 }, { "InterPro-ID": "IPR018143", "InterPro-Name": "Folate_rcpt-like", "InterPro-Type": "DOMAIN", "Beg": 26, "End": 202 } ], "response#1": "MAQWWLILLGLWTVLPSLAGGKLLNVCMNSKHHKQEPGPEDKLYFECMPWKDNACCTRDTSWEAHLDEPLLFNFSMTHCGLLTPLCHKHFIQAICFYECSPNLGPWIQPVVPNRQEEQRLWDVPLCLEDCEEWWKDCRTSHTCKADWLHGWVWDQGKNGCPAHAPCLPFSDYFPTPADLCEKIWNNTFKASPERRNSGRCLQKWFEPTHGNPNVEVALHFAGSASAPQLSYSITAFSLCLLLHA", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Folate_rcpt-like that are essential for its biological function; 2. The protein should belong to Folate_rcpt that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MAQWWLILLGLWTVLPSLAGGKLLNVCMNSKHHKQEPGPEDKLYFECMPWKDNACCTRDTSWEAHLDEPLLFNFSMTHCGLLTPLCHKHFIQAICFYECSPNLGPWIQPVVPNRQEEQRLWDVPLCLEDCEEWWKDCRTSHTCKADWLHGWVWDQGKNGCPAHAPCLPFSDYFPTPADLCEKIWNNTFKASPERRNSGRCLQKWFEPTHGNPNVEVALHFAGSASAPQLSYSITAFSLCLLLHA" }, { "InterPro": [ { "InterPro-ID": "IPR001576", "InterPro-Name": "Phosphoglycerate_kinase", "InterPro-Type": "FAMILY", "Beg": 5, "End": 416 }, { "InterPro-ID": "IPR001576", "InterPro-Name": "Phosphoglycerate_kinase", "InterPro-Type": "FAMILY", "Beg": 9, "End": 406 }, { "InterPro-ID": "IPR036043", "InterPro-Name": "Phosphoglycerate_kinase_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 2, "End": 415 }, { "InterPro-ID": "IPR015824", "InterPro-Name": "Phosphoglycerate_kinase_N", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 203, "End": 392 }, { "InterPro-ID": "IPR001576", "InterPro-Name": "Phosphoglycerate_kinase", "InterPro-Type": "FAMILY", "Beg": 9, "End": 416 }, { "InterPro-ID": "IPR015911", "InterPro-Name": "Phosphoglycerate_kinase_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 18, "End": 28 }, { "InterPro-ID": "IPR015824", "InterPro-Name": "Phosphoglycerate_kinase_N", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 76, "End": 416 }, { "InterPro-ID": "IPR001576", "InterPro-Name": "Phosphoglycerate_kinase", "InterPro-Type": "FAMILY", "Beg": 11, "End": 416 }, { "InterPro-ID": "IPR001576", "InterPro-Name": "Phosphoglycerate_kinase", "InterPro-Type": "FAMILY", "Beg": 1, "End": 417 }, { "InterPro-ID": "IPR015824", "InterPro-Name": "Phosphoglycerate_kinase_N", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1, "End": 73 }, { "InterPro-ID": "IPR001576", "InterPro-Name": "Phosphoglycerate_kinase", "InterPro-Type": "FAMILY", "Beg": 392, "End": 409 }, { "InterPro-ID": "IPR001576", "InterPro-Name": "Phosphoglycerate_kinase", "InterPro-Type": "FAMILY", "Beg": 333, "End": 358 }, { "InterPro-ID": "IPR001576", "InterPro-Name": "Phosphoglycerate_kinase", "InterPro-Type": "FAMILY", "Beg": 157, "End": 179 }, { "InterPro-ID": "IPR001576", "InterPro-Name": "Phosphoglycerate_kinase", "InterPro-Type": "FAMILY", "Beg": 209, "End": 228 }, { "InterPro-ID": "IPR001576", "InterPro-Name": "Phosphoglycerate_kinase", "InterPro-Type": "FAMILY", "Beg": 186, "End": 208 }, { "InterPro-ID": "IPR001576", "InterPro-Name": "Phosphoglycerate_kinase", "InterPro-Type": "FAMILY", "Beg": 35, "End": 57 }, { "InterPro-ID": "IPR001576", "InterPro-Name": "Phosphoglycerate_kinase", "InterPro-Type": "FAMILY", "Beg": 369, "End": 380 }, { "InterPro-ID": "IPR001576", "InterPro-Name": "Phosphoglycerate_kinase", "InterPro-Type": "FAMILY", "Beg": 114, "End": 129 }, { "InterPro-ID": "IPR001576", "InterPro-Name": "Phosphoglycerate_kinase", "InterPro-Type": "FAMILY", "Beg": 13, "End": 29 } ], "response#1": "MSLSNKLAITDVDLKDKRVLIRVDFNVPLDADKKITNNQRIVGALPTIKYAIENGAKAVVLMSHLGRPDGKANPKYSLKPVATELEKLLSKSVIFAENCVGKETEEIVNKATGGQVILLENLRFHAEEEGSSKDAEGKKVKADKEKVEEFRKGLTALGDVYINDAFGTAHRAHSSMVGVDLPQKASGFLVKKELEYFAKALESPQRPFLAILGGAKVSDKIQLIDNLLPKVNSLIITGAMAFTFKKTLENVKIGNSLFDEAGSKIVGDIVEKAKKNNVKIVLPVDYVTADKFAADAKTGYATDADGIPDGYMGLDVGEKSVELYKKTIAEAKTILWNGPPGVFELEPFANATKKTLDAAVAAAQSGSIVIIGGGDTATVAAKYGAEAKLSHVSTGGGASLELLEGKVLPGVDALSSK", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Phosphoglycerate_kinase, Phosphoglycerate_kinase, Phosphoglycerate_kinase, Phosphoglycerate_kinase, Phosphoglycerate_kinase, Phosphoglycerate_kinase, Phosphoglycerate_kinase, Phosphoglycerate_kinase, Phosphoglycerate_kinase, Phosphoglycerate_kinase, Phosphoglycerate_kinase, Phosphoglycerate_kinase, Phosphoglycerate_kinase, Phosphoglycerate_kinase that shares evolutionary origin and functional similarity; 2. The protein should be classified within Phosphoglycerate_kinase_sf, Phosphoglycerate_kinase_N, Phosphoglycerate_kinase_N, Phosphoglycerate_kinase_N sharing conserved structural features; 3. The protein should contain Phosphoglycerate_kinase_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MSLSNKLAITDVDLKDKRVLIRVDFNVPLDADKKITNNQRIVGALPTIKYAIENGAKAVVLMSHLGRPDGKANPKYSLKPVATELEKLLSKSVIFAENCVGKETEEIVNKATGGQVILLENLRFHAEEEGSSKDAEGKKVKADKEKVEEFRKGLTALGDVYINDAFGTAHRAHSSMVGVDLPQKASGFLVKKELEYFAKALESPQRPFLAILGGAKVSDKIQLIDNLLPKVNSLIITGAMAFTFKKTLENVKIGNSLFDEAGSKIVGDIVEKAKKNNVKIVLPVDYVTADKFAADAKTGYATDADGIPDGYMGLDVGEKSVELYKKTIAEAKTILWNGPPGVFELEPFANATKKTLDAAVAAAQSGSIVIIGGGDTATVAAKYGAEAKLSHVSTGGGASLELLEGKVLPGVDALSSK" }, { "InterPro": [ { "InterPro-ID": "IPR006158", "InterPro-Name": "Cobalamin-bd", "InterPro-Type": "DOMAIN", "Beg": 65, "End": 134 }, { "InterPro-ID": "IPR006158", "InterPro-Name": "Cobalamin-bd", "InterPro-Type": "DOMAIN", "Beg": 1, "End": 144 }, { "InterPro-ID": "IPR034514", "InterPro-Name": "ThnK-like", "InterPro-Type": "FAMILY", "Beg": 6, "End": 680 }, { "InterPro-ID": "IPR023404", "InterPro-Name": "rSAM_horseshoe", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 195, "End": 388 }, { "InterPro-ID": "IPR036724", "InterPro-Name": "Cobalamin-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 65, "End": 139 }, { "InterPro-ID": "IPR006638", "InterPro-Name": "Elp3/MiaA/NifB-like_rSAM", "InterPro-Type": "DOMAIN", "Beg": 196, "End": 414 }, { "InterPro-ID": "IPR051198", "InterPro-Name": "Tetrapyrrole_Bchl_Biosynth_MTs", "InterPro-Type": "FAMILY", "Beg": 62, "End": 434 }, { "InterPro-ID": "IPR007197", "InterPro-Name": "rSAM", "InterPro-Type": "DOMAIN", "Beg": 192, "End": 417 } ], "response#1": "MSAELASRGRKVYFVGLNEYPFLPLVAGLLRTYAEQDERIAAAYDFQEPVFLVAPVQEMADGIVEPDVLALSCYVWNFRRQMKVAKLVKERYPNVLVVAGGPHVPDRPGNFFEKHPYVDVLAHGEGEVAFRELLATRLSDHPDYTAVPGVSVRRGTEAVVGPKAKRLPRLIDTPSPYLLGVMDGAVATCRERGLRFYALWETNRGCPYSCSFCDWGSATMSTLRKFEDERLQDEIEWFARHDVEDLFICDANFGIMPRDLEIAHALAEARGELGAPRQVRVNFAKNSNDRVFDISKTWHDADLLMGTTLSMQSTDMDVLEAIDRKNIGLDNYRKLQQRYAAENIHTYTELILGLPMETARSFRDGIGSLLEAGNHEDLRVYELGILPNAPLNTPEKIEQYGLRTVPKRMYVERPGTPDDEAETFEMVMETNAMPRDAWVESFSFIQAVQFLHNGCYTRYLSIFLRQEHGIGYTRFYEGLQDYFTGRPDTVLGALYLRMRSLYHDYIDMPALPLANLVASQPDMAADLAPYGRRRGWTIDNWGWLRIATDFDRFHTELREYLATLGLDPAGDARLEDVLRFQQDVMLRPDYSPELGKSAEYAHDWPGYFAGGLLRPRRVRVAYGDQSFGANGRYRPVPGDLKAFTMAAIGTSYPVSRMGHFCHRFESAEVTSLAEPVVSEQW", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Cobalamin-bd, Cobalamin-bd, Elp3/MiaA/NifB-like_rSAM, rSAM that are essential for its biological function; 2. The protein should belong to ThnK-like, Tetrapyrrole_Bchl_Biosynth_MTs that shares evolutionary origin and functional similarity; 3. The protein should be classified within rSAM_horseshoe, Cobalamin-bd_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MSAELASRGRKVYFVGLNEYPFLPLVAGLLRTYAEQDERIAAAYDFQEPVFLVAPVQEMADGIVEPDVLALSCYVWNFRRQMKVAKLVKERYPNVLVVAGGPHVPDRPGNFFEKHPYVDVLAHGEGEVAFRELLATRLSDHPDYTAVPGVSVRRGTEAVVGPKAKRLPRLIDTPSPYLLGVMDGAVATCRERGLRFYALWETNRGCPYSCSFCDWGSATMSTLRKFEDERLQDEIEWFARHDVEDLFICDANFGIMPRDLEIAHALAEARGELGAPRQVRVNFAKNSNDRVFDISKTWHDADLLMGTTLSMQSTDMDVLEAIDRKNIGLDNYRKLQQRYAAENIHTYTELILGLPMETARSFRDGIGSLLEAGNHEDLRVYELGILPNAPLNTPEKIEQYGLRTVPKRMYVERPGTPDDEAETFEMVMETNAMPRDAWVESFSFIQAVQFLHNGCYTRYLSIFLRQEHGIGYTRFYEGLQDYFTGRPDTVLGALYLRMRSLYHDYIDMPALPLANLVASQPDMAADLAPYGRRRGWTIDNWGWLRIATDFDRFHTELREYLATLGLDPAGDARLEDVLRFQQDVMLRPDYSPELGKSAEYAHDWPGYFAGGLLRPRRVRVAYGDQSFGANGRYRPVPGDLKAFTMAAIGTSYPVSRMGHFCHRFESAEVTSLAEPVVSEQW" }, { "InterPro": [ { "InterPro-ID": "IPR002227", "InterPro-Name": "Tyrosinase_Cu-bd", "InterPro-Type": "DOMAIN", "Beg": 78, "End": 95 }, { "InterPro-ID": "IPR008922", "InterPro-Name": "Di-copper_centre_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 2, "End": 295 }, { "InterPro-ID": "IPR002227", "InterPro-Name": "Tyrosinase_Cu-bd", "InterPro-Type": "DOMAIN", "Beg": 231, "End": 242 }, { "InterPro-ID": "IPR050316", "InterPro-Name": "Tyrosinase/Hemocyanin", "InterPro-Type": "FAMILY", "Beg": 3, "End": 328 }, { "InterPro-ID": "IPR022739", "InterPro-Name": "Polyphenol_oxidase_cen", "InterPro-Type": "DOMAIN", "Beg": 262, "End": 296 }, { "InterPro-ID": "IPR002227", "InterPro-Name": "Tyrosinase_Cu-bd", "InterPro-Type": "DOMAIN", "Beg": 210, "End": 221 }, { "InterPro-ID": "IPR002227", "InterPro-Name": "Tyrosinase_Cu-bd", "InterPro-Type": "DOMAIN", "Beg": 230, "End": 248 }, { "InterPro-ID": "IPR002227", "InterPro-Name": "Tyrosinase_Cu-bd", "InterPro-Type": "DOMAIN", "Beg": 113, "End": 118 }, { "InterPro-ID": "IPR002227", "InterPro-Name": "Tyrosinase_Cu-bd", "InterPro-Type": "DOMAIN", "Beg": 34, "End": 250 }, { "InterPro-ID": "IPR008922", "InterPro-Name": "Di-copper_centre_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1, "End": 298 } ], "response#1": "MKTRQNVYELKDDTLSWYSRAVEEMKSRDINDPTSWWYQGAIHGYATYPSALTYWHDATGYPPSQQTVNSGFWNRCQHGTWYFLPWHRMYLFYFEEIVAKAIRDMGGPADWTLPYWNYCEAYNTSASPSNQQQALQIPPEFGSSQGPNADFASLWIKNRRNYVLNKNNVNPWPAMNEAEFTNSGGDISFGGGVTGFAHSGGQTGQLESLPHNVVHTDINGAMGNPDTAALDPIFWLHHANIDRLWQVWLAQAGRSNPVVNAWKDFRFKFHDANGQPVEIAVKDVETTQLLGYVYTPAFPLSSTTPARRSVPAMDVVGATSASFSVGDHMAPLDLTMVPQPARGARLLAARGGDEKRTILRISNVKGKGATSPIDLFITNRDNEEGNEENFVGCIGLFGLENASTPSVESDGSGLNFAIDISDTINKLRQRDDWDEDNIRVQLIPQSKQDSDVEINVGRVSLHSEID", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Tyrosinase_Cu-bd, Tyrosinase_Cu-bd, Polyphenol_oxidase_cen, Tyrosinase_Cu-bd, Tyrosinase_Cu-bd, Tyrosinase_Cu-bd, Tyrosinase_Cu-bd that are essential for its biological function; 2. The protein should belong to Tyrosinase/Hemocyanin that shares evolutionary origin and functional similarity; 3. The protein should be classified within Di-copper_centre_dom_sf, Di-copper_centre_dom_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MKTRQNVYELKDDTLSWYSRAVEEMKSRDINDPTSWWYQGAIHGYATYPSALTYWHDATGYPPSQQTVNSGFWNRCQHGTWYFLPWHRMYLFYFEEIVAKAIRDMGGPADWTLPYWNYCEAYNTSASPSNQQQALQIPPEFGSSQGPNADFASLWIKNRRNYVLNKNNVNPWPAMNEAEFTNSGGDISFGGGVTGFAHSGGQTGQLESLPHNVVHTDINGAMGNPDTAALDPIFWLHHANIDRLWQVWLAQAGRSNPVVNAWKDFRFKFHDANGQPVEIAVKDVETTQLLGYVYTPAFPLSSTTPARRSVPAMDVVGATSASFSVGDHMAPLDLTMVPQPARGARLLAARGGDEKRTILRISNVKGKGATSPIDLFITNRDNEEGNEENFVGCIGLFGLENASTPSVESDGSGLNFAIDISDTINKLRQRDDWDEDNIRVQLIPQSKQDSDVEINVGRVSLHSEID" }, { "InterPro": [ { "InterPro-ID": "IPR012280", "InterPro-Name": "Semialdhyde_DH_dimer_dom", "InterPro-Type": "DOMAIN", "Beg": 164, "End": 342 }, { "InterPro-ID": "IPR000319", "InterPro-Name": "Asp-semialdehyde_DH_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 238, "End": 252 }, { "InterPro-ID": "IPR051823", "InterPro-Name": "ASADH-related", "InterPro-Type": "FAMILY", "Beg": 6, "End": 362 }, { "InterPro-ID": "IPR036291", "InterPro-Name": "NAD(P)-bd_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 7, "End": 171 }, { "InterPro-ID": "IPR005676", "InterPro-Name": "Asp_semi-ald_DH_pep-lack", "InterPro-Type": "FAMILY", "Beg": 8, "End": 356 }, { "InterPro-ID": "IPR000534", "InterPro-Name": "Semialdehyde_DH_NAD-bd", "InterPro-Type": "DOMAIN", "Beg": 9, "End": 132 }, { "InterPro-ID": "IPR000534", "InterPro-Name": "Semialdehyde_DH_NAD-bd", "InterPro-Type": "DOMAIN", "Beg": 8, "End": 134 } ], "response#1": "MSTPSKKRCGVLGATGAVGTRFILLLEQSPLLELVAVGASERSAGKKYRDAVRWKQASPMPASVADLTVRRCAPSEFSDCDIIFSGLDPVAAGDIEMAFLKANFAVFSNAKNYRLDPIVPLVVPLVNAGHIDVIPAQRKHYGLDKGLIVCNSNCAVVGLVIPAKALIQKFGPIESVSMVTMQAVSGAGYPGVSSMDIFDNIVPFIPGEEGKIATESRKILGNLNPDLAGFSDQQPLQVSVACNRVPVLDGHTVCASLRFVNRPAPTASQVRDALREYKSEVQLLGCPSAPRQAIHVLDDVDRPQPRLDRDTEAGYACSVGRIREDDSGVFDIQFVALSHNTVLGASGSSILNAESAILKGYI", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Semialdhyde_DH_dimer_dom, Semialdehyde_DH_NAD-bd, Semialdehyde_DH_NAD-bd that are essential for its biological function; 2. The protein should belong to ASADH-related, Asp_semi-ald_DH_pep-lack that shares evolutionary origin and functional similarity; 3. The protein should be classified within NAD(P)-bd_dom_sf sharing conserved structural features; 4. The protein should contain Asp-semialdehyde_DH_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MSTPSKKRCGVLGATGAVGTRFILLLEQSPLLELVAVGASERSAGKKYRDAVRWKQASPMPASVADLTVRRCAPSEFSDCDIIFSGLDPVAAGDIEMAFLKANFAVFSNAKNYRLDPIVPLVVPLVNAGHIDVIPAQRKHYGLDKGLIVCNSNCAVVGLVIPAKALIQKFGPIESVSMVTMQAVSGAGYPGVSSMDIFDNIVPFIPGEEGKIATESRKILGNLNPDLAGFSDQQPLQVSVACNRVPVLDGHTVCASLRFVNRPAPTASQVRDALREYKSEVQLLGCPSAPRQAIHVLDDVDRPQPRLDRDTEAGYACSVGRIREDDSGVFDIQFVALSHNTVLGASGSSILNAESAILKGYI" }, { "InterPro": [ { "InterPro-ID": "IPR013898", "InterPro-Name": "Atg43", "InterPro-Type": "FAMILY", "Beg": 7, "End": 93 } ], "response#1": "MNVPTAPTPNKHLNIPDLRFEKVFKKALHRELAPSSSLSRKAGVITKVVVRDVLLMPLLQSFVLSLALMGVKEWLSYIRLKGRTLGDRIRQRLFPI", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Atg43 that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MNVPTAPTPNKHLNIPDLRFEKVFKKALHRELAPSSSLSRKAGVITKVVVRDVLLMPLLQSFVLSLALMGVKEWLSYIRLKGRTLGDRIRQRLFPI" }, { "InterPro": [ { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 39, "End": 488 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 351, "End": 362 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 292, "End": 309 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 444, "End": 453 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 453, "End": 464 }, { "InterPro-ID": "IPR002403", "InterPro-Name": "Cyt_P450_E_grp-IV", "InterPro-Type": "FAMILY", "Beg": 36, "End": 53 }, { "InterPro-ID": "IPR002403", "InterPro-Name": "Cyt_P450_E_grp-IV", "InterPro-Type": "FAMILY", "Beg": 58, "End": 81 }, { "InterPro-ID": "IPR002403", "InterPro-Name": "Cyt_P450_E_grp-IV", "InterPro-Type": "FAMILY", "Beg": 381, "End": 395 }, { "InterPro-ID": "IPR002403", "InterPro-Name": "Cyt_P450_E_grp-IV", "InterPro-Type": "FAMILY", "Beg": 453, "End": 471 }, { "InterPro-ID": "IPR002403", "InterPro-Name": "Cyt_P450_E_grp-IV", "InterPro-Type": "FAMILY", "Beg": 283, "End": 309 }, { "InterPro-ID": "IPR002403", "InterPro-Name": "Cyt_P450_E_grp-IV", "InterPro-Type": "FAMILY", "Beg": 346, "End": 362 }, { "InterPro-ID": "IPR002403", "InterPro-Name": "Cyt_P450_E_grp-IV", "InterPro-Type": "FAMILY", "Beg": 397, "End": 415 }, { "InterPro-ID": "IPR002403", "InterPro-Name": "Cyt_P450_E_grp-IV", "InterPro-Type": "FAMILY", "Beg": 437, "End": 453 }, { "InterPro-ID": "IPR017972", "InterPro-Name": "Cyt_P450_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 446, "End": 455 }, { "InterPro-ID": "IPR036396", "InterPro-Name": "Cyt_P450_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 33, "End": 512 }, { "InterPro-ID": "IPR036396", "InterPro-Name": "Cyt_P450_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 27, "End": 508 }, { "InterPro-ID": "IPR050529", "InterPro-Name": "CYP450_sterol_14alpha_dmase", "InterPro-Type": "FAMILY", "Beg": 10, "End": 501 } ], "response#1": "MSWPLIGAYALLAFVAIIALNVTYQFLFRLLNKTRPPLVFHWIPFIGSTIHYGMDPYGFFFSCREKYGDIFTFILLGRPTTVYLGTQGNEFILNGKLKDVNAEEVYSPLTTPVFGSDVVYDCPNSKLIEQKKFIKFGLSQTALEAHVPLIEKEVEDYLAMSPNFHGTSGEVDITAAMAEITIFTAGSALQGEEVRSKLTTEFAVLYHDLDKGFTPINFMLPWAPLPHNKKRDAAHARMRAIYIDIINKRRNAGDNVPEKLDMIGNLMQCTYKNGQPLPDKEIAHIMITLLMAGQHSSSSISSWIMLRLASQPAVVEELYQEQLANLERTGPNNSLAPLQYKDFDNLPLHQNVIRETLRLNSSIHSLMRKVKNPLPVPGTPYVIPTSHVLLSAPGVTALSDEYFPNAMAWDPHRWETQAPKENDKDDIVDYGYGAISKGTSSPYLPFGAGRHRCIGEKFAYLNLAVIVATMVRHLRFSNLDGQTGVPATDYSSLFSGPMKPARIRWERRAAKSG", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Cyt_P450, Cyt_P450, Cyt_P450, Cyt_P450, Cyt_P450, Cyt_P450_E_grp-IV, Cyt_P450_E_grp-IV, Cyt_P450_E_grp-IV, Cyt_P450_E_grp-IV, Cyt_P450_E_grp-IV, Cyt_P450_E_grp-IV, Cyt_P450_E_grp-IV, Cyt_P450_E_grp-IV, CYP450_sterol_14alpha_dmase that shares evolutionary origin and functional similarity; 2. The protein should be classified within Cyt_P450_sf, Cyt_P450_sf sharing conserved structural features; 3. The protein should contain Cyt_P450_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MSWPLIGAYALLAFVAIIALNVTYQFLFRLLNKTRPPLVFHWIPFIGSTIHYGMDPYGFFFSCREKYGDIFTFILLGRPTTVYLGTQGNEFILNGKLKDVNAEEVYSPLTTPVFGSDVVYDCPNSKLIEQKKFIKFGLSQTALEAHVPLIEKEVEDYLAMSPNFHGTSGEVDITAAMAEITIFTAGSALQGEEVRSKLTTEFAVLYHDLDKGFTPINFMLPWAPLPHNKKRDAAHARMRAIYIDIINKRRNAGDNVPEKLDMIGNLMQCTYKNGQPLPDKEIAHIMITLLMAGQHSSSSISSWIMLRLASQPAVVEELYQEQLANLERTGPNNSLAPLQYKDFDNLPLHQNVIRETLRLNSSIHSLMRKVKNPLPVPGTPYVIPTSHVLLSAPGVTALSDEYFPNAMAWDPHRWETQAPKENDKDDIVDYGYGAISKGTSSPYLPFGAGRHRCIGEKFAYLNLAVIVATMVRHLRFSNLDGQTGVPATDYSSLFSGPMKPARIRWERRAAKSG" }, { "InterPro": [ { "InterPro-ID": "IPR041529", "InterPro-Name": "DUF5598", "InterPro-Type": "DOMAIN", "Beg": 6, "End": 99 }, { "InterPro-ID": "IPR016471", "InterPro-Name": "Nicotinamide_PRibTrfase", "InterPro-Type": "FAMILY", "Beg": 8, "End": 409 }, { "InterPro-ID": "IPR041525", "InterPro-Name": "N/Namide_PRibTrfase", "InterPro-Type": "DOMAIN", "Beg": 172, "End": 417 }, { "InterPro-ID": "IPR016471", "InterPro-Name": "Nicotinamide_PRibTrfase", "InterPro-Type": "FAMILY", "Beg": 6, "End": 465 }, { "InterPro-ID": "IPR013785", "InterPro-Name": "Aldolase_TIM", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 137, "End": 399 }, { "InterPro-ID": "IPR036068", "InterPro-Name": "Nicotinate_pribotase-like_C", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 171, "End": 464 }, { "InterPro-ID": "IPR016471", "InterPro-Name": "Nicotinamide_PRibTrfase", "InterPro-Type": "FAMILY", "Beg": 1, "End": 468 } ], "response#1": "MHYLDNLLLNTDSYKASHWLQYPPGTDASFFYVESRGGVYDQTAFFGLQSILKEAINRPVTHADIDDAKALLAAHGEPFNEAGWRDIVDRLGGQLPIRIRAVPEGCVVPTHNVLMTIESTDAKAFWVPSYLETLLLRVWYPVTVATVSWQVKQIVRDFLQRTSDDPEGQLPFKLHDFGARGVSSLGSAALGGAAHLVNFLGTDTLSALLLARAHYHTPVAGYSIPAAEHSTITSWGREREVDAYRNMLTQFARPGAIVAVVSDSYDIYRAIREHWGTTLREEIIASGATVVIRPDSGDPVDVVEQCLLLLDEAFGHQVNGKGYKVLNHVRVIQGDGINPQSLRAILERITAAGYAADNVAFGMGGALLQKVDRDTQKFALKCSAVRVDGAWIDVYKDPITDQGKQSKRGRLTLLRDRATGQYRSALLDEVATHAGDSDDALVTVWENGQMLREWTLEQVRAHADAARL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more DUF5598, N/Namide_PRibTrfase that are essential for its biological function; 2. The protein should belong to Nicotinamide_PRibTrfase, Nicotinamide_PRibTrfase, Nicotinamide_PRibTrfase that shares evolutionary origin and functional similarity; 3. The protein should be classified within Aldolase_TIM, Nicotinate_pribotase-like_C sharing conserved structural features. The designed protein sequence is ", "reference": "MHYLDNLLLNTDSYKASHWLQYPPGTDASFFYVESRGGVYDQTAFFGLQSILKEAINRPVTHADIDDAKALLAAHGEPFNEAGWRDIVDRLGGQLPIRIRAVPEGCVVPTHNVLMTIESTDAKAFWVPSYLETLLLRVWYPVTVATVSWQVKQIVRDFLQRTSDDPEGQLPFKLHDFGARGVSSLGSAALGGAAHLVNFLGTDTLSALLLARAHYHTPVAGYSIPAAEHSTITSWGREREVDAYRNMLTQFARPGAIVAVVSDSYDIYRAIREHWGTTLREEIIASGATVVIRPDSGDPVDVVEQCLLLLDEAFGHQVNGKGYKVLNHVRVIQGDGINPQSLRAILERITAAGYAADNVAFGMGGALLQKVDRDTQKFALKCSAVRVDGAWIDVYKDPITDQGKQSKRGRLTLLRDRATGQYRSALLDEVATHAGDSDDALVTVWENGQMLREWTLEQVRAHADAARL" }, { "InterPro": [ { "InterPro-ID": "IPR010985", "InterPro-Name": "Ribbon_hlx_hlx", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 11, "End": 86 }, { "InterPro-ID": "IPR014795", "InterPro-Name": "TacA_1-like", "InterPro-Type": "FAMILY", "Beg": 2, "End": 94 }, { "InterPro-ID": "IPR014795", "InterPro-Name": "TacA_1-like", "InterPro-Type": "FAMILY", "Beg": 13, "End": 89 } ], "response#1": "MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADDPVIEKLLARKPQWDV", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to TacA_1-like, TacA_1-like that shares evolutionary origin and functional similarity; 2. The protein should be classified within Ribbon_hlx_hlx sharing conserved structural features. The designed protein sequence is ", "reference": "MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADDPVIEKLLARKPQWDV" }, { "InterPro": [ { "InterPro-ID": "IPR000182", "InterPro-Name": "GNAT_dom", "InterPro-Type": "DOMAIN", "Beg": 44, "End": 146 }, { "InterPro-ID": "IPR016181", "InterPro-Name": "Acyl_CoA_acyltransferase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 21, "End": 147 } ], "response#1": "MGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNMPDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLPQ", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more GNAT_dom that are essential for its biological function; 2. The protein should be classified within Acyl_CoA_acyltransferase sharing conserved structural features. The designed protein sequence is ", "reference": "MGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNMPDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLPQ" }, { "InterPro": [ { "InterPro-ID": "IPR016181", "InterPro-Name": "Acyl_CoA_acyltransferase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 5, "End": 152 }, { "InterPro-ID": "IPR000182", "InterPro-Name": "GNAT_dom", "InterPro-Type": "DOMAIN", "Beg": 69, "End": 147 } ], "response#1": "MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISKGLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLLSFKTLYAALSASGRL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more GNAT_dom that are essential for its biological function; 2. The protein should be classified within Acyl_CoA_acyltransferase sharing conserved structural features. The designed protein sequence is ", "reference": "MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISKGLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLLSFKTLYAALSASGRL" }, { "InterPro": [ { "InterPro-ID": "IPR014795", "InterPro-Name": "TacA_1-like", "InterPro-Type": "FAMILY", "Beg": 3, "End": 95 }, { "InterPro-ID": "IPR014795", "InterPro-Name": "TacA_1-like", "InterPro-Type": "FAMILY", "Beg": 14, "End": 90 }, { "InterPro-ID": "IPR010985", "InterPro-Name": "Ribbon_hlx_hlx", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 11, "End": 87 } ], "response#1": "MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAPNEKLLAAAFALPDMKK", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to TacA_1-like, TacA_1-like that shares evolutionary origin and functional similarity; 2. The protein should be classified within Ribbon_hlx_hlx sharing conserved structural features. The designed protein sequence is ", "reference": "MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAPNEKLLAAAFALPDMKK" }, { "InterPro": [ { "InterPro-ID": "IPR013319", "InterPro-Name": "GH11/12", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 33, "End": 226 }, { "InterPro-ID": "IPR000254", "InterPro-Name": "Cellulose-bd_dom_fun", "InterPro-Type": "DOMAIN", "Beg": 255, "End": 291 }, { "InterPro-ID": "IPR035971", "InterPro-Name": "CBD_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 258, "End": 291 }, { "InterPro-ID": "IPR033119", "InterPro-Name": "GH11_AS_2", "InterPro-Type": "ACTIVE_SITE", "Beg": 206, "End": 217 }, { "InterPro-ID": "IPR001137", "InterPro-Name": "Glyco_hydro_11", "InterPro-Type": "FAMILY", "Beg": 143, "End": 149 }, { "InterPro-ID": "IPR001137", "InterPro-Name": "Glyco_hydro_11", "InterPro-Type": "FAMILY", "Beg": 168, "End": 177 }, { "InterPro-ID": "IPR001137", "InterPro-Name": "Glyco_hydro_11", "InterPro-Type": "FAMILY", "Beg": 115, "End": 125 }, { "InterPro-ID": "IPR001137", "InterPro-Name": "Glyco_hydro_11", "InterPro-Type": "FAMILY", "Beg": 191, "End": 199 }, { "InterPro-ID": "IPR001137", "InterPro-Name": "Glyco_hydro_11", "InterPro-Type": "FAMILY", "Beg": 105, "End": 114 }, { "InterPro-ID": "IPR001137", "InterPro-Name": "Glyco_hydro_11", "InterPro-Type": "FAMILY", "Beg": 163, "End": 168 }, { "InterPro-ID": "IPR018208", "InterPro-Name": "GH11_AS_1", "InterPro-Type": "ACTIVE_SITE", "Beg": 115, "End": 125 }, { "InterPro-ID": "IPR000254", "InterPro-Name": "Cellulose-bd_dom_fun", "InterPro-Type": "DOMAIN", "Beg": 258, "End": 291 }, { "InterPro-ID": "IPR033123", "InterPro-Name": "GH11_dom", "InterPro-Type": "DOMAIN", "Beg": 43, "End": 219 }, { "InterPro-ID": "IPR033123", "InterPro-Name": "GH11_dom", "InterPro-Type": "DOMAIN", "Beg": 34, "End": 222 }, { "InterPro-ID": "IPR000254", "InterPro-Name": "Cellulose-bd_dom_fun", "InterPro-Type": "DOMAIN", "Beg": 259, "End": 287 }, { "InterPro-ID": "IPR000254", "InterPro-Name": "Cellulose-bd_dom_fun", "InterPro-Type": "DOMAIN", "Beg": 263, "End": 290 }, { "InterPro-ID": "IPR013320", "InterPro-Name": "ConA-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 34, "End": 221 }, { "InterPro-ID": "IPR001137", "InterPro-Name": "Glyco_hydro_11", "InterPro-Type": "FAMILY", "Beg": 1, "End": 222 } ], "response#1": "MVAFSSLFLGASIAATALAAPGELPGMHLNKRQTYTQSATGTHDGYYFSFWTDGGPNVRYTNEAGGQYSVTWSGNGNWVGGKGWNPGAARTINYTGTYQPNGNSYLAVYGWTRNPLVEYYVVENFGTYDPSTGAQRLGSINVDGSTYNVYRTRRTNAPSIEGTRSFDQYWSVRVNKRVGGSVDMNAHFNAWRQAGLTLGTHDYQIVATEGYFSSGSARINVGGGSTGGGNNGGGNNGGNPGGNPGGNPGGNPGGNCSPRWGQCGGQGWNGPTCCESGTTCRQQNQWYSQCL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Cellulose-bd_dom_fun, Cellulose-bd_dom_fun, GH11_dom, GH11_dom, Cellulose-bd_dom_fun, Cellulose-bd_dom_fun that are essential for its biological function; 2. The protein should belong to Glyco_hydro_11, Glyco_hydro_11, Glyco_hydro_11, Glyco_hydro_11, Glyco_hydro_11, Glyco_hydro_11, Glyco_hydro_11 that shares evolutionary origin and functional similarity; 3. The protein should be classified within GH11/12, CBD_sf, ConA-like_dom_sf sharing conserved structural features; 4. The protein must have GH11_AS_2, GH11_AS_1 that is conserved among related catalytic enzymes. The designed protein sequence is ", "reference": "MVAFSSLFLGASIAATALAAPGELPGMHLNKRQTYTQSATGTHDGYYFSFWTDGGPNVRYTNEAGGQYSVTWSGNGNWVGGKGWNPGAARTINYTGTYQPNGNSYLAVYGWTRNPLVEYYVVENFGTYDPSTGAQRLGSINVDGSTYNVYRTRRTNAPSIEGTRSFDQYWSVRVNKRVGGSVDMNAHFNAWRQAGLTLGTHDYQIVATEGYFSSGSARINVGGGSTGGGNNGGGNNGGNPGGNPGGNPGGNPGGNCSPRWGQCGGQGWNGPTCCESGTTCRQQNQWYSQCL" }, { "InterPro": [ { "InterPro-ID": "IPR036291", "InterPro-Name": "NAD(P)-bd_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 8, "End": 182 }, { "InterPro-ID": "IPR000319", "InterPro-Name": "Asp-semialdehyde_DH_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 238, "End": 252 }, { "InterPro-ID": "IPR000534", "InterPro-Name": "Semialdehyde_DH_NAD-bd", "InterPro-Type": "DOMAIN", "Beg": 9, "End": 132 }, { "InterPro-ID": "IPR005676", "InterPro-Name": "Asp_semi-ald_DH_pep-lack", "InterPro-Type": "FAMILY", "Beg": 8, "End": 356 }, { "InterPro-ID": "IPR051823", "InterPro-Name": "ASADH-related", "InterPro-Type": "FAMILY", "Beg": 6, "End": 361 }, { "InterPro-ID": "IPR012280", "InterPro-Name": "Semialdhyde_DH_dimer_dom", "InterPro-Type": "DOMAIN", "Beg": 164, "End": 342 }, { "InterPro-ID": "IPR000534", "InterPro-Name": "Semialdehyde_DH_NAD-bd", "InterPro-Type": "DOMAIN", "Beg": 8, "End": 134 } ], "response#1": "MATPSKKRCGVLGATGAVGTRFILLLSQHPLLELVAVGASDRSSGKKYRDAVRWKQSAPMPAKVADLTVRCCDPAEFSDCDIIFSGLDPDAAGEIEMAFLKANFAVFSNAKNYRLDPMVPLVVPLVNAGHIDVIPAQRKHFGLDKGMLVCNSNCAVVGLVVPAKALIQKFGPIESVSMVTMQAVSGAGYPGVSSMDIFDNIVPYIPGEEGKISSEARKILGDLNSDLAGFSDQKPLQISVACNRVPVLDGHTVCASLRFVNRPPPTASQVREALREYKPEVQTLGCPSAPKMSIHVMDEVDRPQPRLDRETEGGYACTVGRIREDDSDVFDIQFVALSHNTVLGASGSSILNAESAILKGFV", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Semialdehyde_DH_NAD-bd, Semialdhyde_DH_dimer_dom, Semialdehyde_DH_NAD-bd that are essential for its biological function; 2. The protein should belong to Asp_semi-ald_DH_pep-lack, ASADH-related that shares evolutionary origin and functional similarity; 3. The protein should be classified within NAD(P)-bd_dom_sf sharing conserved structural features; 4. The protein should contain Asp-semialdehyde_DH_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MATPSKKRCGVLGATGAVGTRFILLLSQHPLLELVAVGASDRSSGKKYRDAVRWKQSAPMPAKVADLTVRCCDPAEFSDCDIIFSGLDPDAAGEIEMAFLKANFAVFSNAKNYRLDPMVPLVVPLVNAGHIDVIPAQRKHFGLDKGMLVCNSNCAVVGLVVPAKALIQKFGPIESVSMVTMQAVSGAGYPGVSSMDIFDNIVPYIPGEEGKISSEARKILGDLNSDLAGFSDQKPLQISVACNRVPVLDGHTVCASLRFVNRPPPTASQVREALREYKPEVQTLGCPSAPKMSIHVMDEVDRPQPRLDRETEGGYACTVGRIREDDSDVFDIQFVALSHNTVLGASGSSILNAESAILKGFV" }, { "InterPro": [ { "InterPro-ID": "IPR035892", "InterPro-Name": "C2_domain_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1050, "End": 1160 }, { "InterPro-ID": "IPR035892", "InterPro-Name": "C2_domain_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 524, "End": 665 }, { "InterPro-ID": "IPR000008", "InterPro-Name": "C2_dom", "InterPro-Type": "DOMAIN", "Beg": 674, "End": 787 }, { "InterPro-ID": "IPR000008", "InterPro-Name": "C2_dom", "InterPro-Type": "DOMAIN", "Beg": 1051, "End": 1159 }, { "InterPro-ID": "IPR000008", "InterPro-Name": "C2_dom", "InterPro-Type": "DOMAIN", "Beg": 524, "End": 627 }, { "InterPro-ID": "IPR000008", "InterPro-Name": "C2_dom", "InterPro-Type": "DOMAIN", "Beg": 1213, "End": 1317 }, { "InterPro-ID": "IPR000008", "InterPro-Name": "C2_dom", "InterPro-Type": "DOMAIN", "Beg": 9, "End": 119 }, { "InterPro-ID": "IPR000008", "InterPro-Name": "C2_dom", "InterPro-Type": "DOMAIN", "Beg": 179, "End": 280 }, { "InterPro-ID": "IPR000008", "InterPro-Name": "C2_dom", "InterPro-Type": "DOMAIN", "Beg": 506, "End": 629 }, { "InterPro-ID": "IPR000008", "InterPro-Name": "C2_dom", "InterPro-Type": "DOMAIN", "Beg": 1192, "End": 1319 }, { "InterPro-ID": "IPR000008", "InterPro-Name": "C2_dom", "InterPro-Type": "DOMAIN", "Beg": 1032, "End": 1160 }, { "InterPro-ID": "IPR000008", "InterPro-Name": "C2_dom", "InterPro-Type": "DOMAIN", "Beg": 161, "End": 281 }, { "InterPro-ID": "IPR035892", "InterPro-Name": "C2_domain_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 158, "End": 293 }, { "InterPro-ID": "IPR035892", "InterPro-Name": "C2_domain_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 516, "End": 653 }, { "InterPro-ID": "IPR035892", "InterPro-Name": "C2_domain_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1203, "End": 1333 }, { "InterPro-ID": "IPR035892", "InterPro-Name": "C2_domain_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 2, "End": 143 }, { "InterPro-ID": "IPR035892", "InterPro-Name": "C2_domain_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 171, "End": 287 }, { "InterPro-ID": "IPR012968", "InterPro-Name": "FerIin_dom", "InterPro-Type": "DOMAIN", "Beg": 105, "End": 173 }, { "InterPro-ID": "IPR000008", "InterPro-Name": "C2_dom", "InterPro-Type": "DOMAIN", "Beg": 179, "End": 282 }, { "InterPro-ID": "IPR000008", "InterPro-Name": "C2_dom", "InterPro-Type": "DOMAIN", "Beg": 10, "End": 109 }, { "InterPro-ID": "IPR000008", "InterPro-Name": "C2_dom", "InterPro-Type": "DOMAIN", "Beg": 529, "End": 629 }, { "InterPro-ID": "IPR000008", "InterPro-Name": "C2_dom", "InterPro-Type": "DOMAIN", "Beg": 1052, "End": 1155 }, { "InterPro-ID": "IPR035892", "InterPro-Name": "C2_domain_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1035, "End": 1184 }, { "InterPro-ID": "IPR035892", "InterPro-Name": "C2_domain_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 8, "End": 145 }, { "InterPro-ID": "IPR037721", "InterPro-Name": "Ferlin", "InterPro-Type": "FAMILY", "Beg": 464, "End": 1163 }, { "InterPro-ID": "IPR037724", "InterPro-Name": "C2E_Ferlin", "InterPro-Type": "DOMAIN", "Beg": 1051, "End": 1184 }, { "InterPro-ID": "IPR000008", "InterPro-Name": "C2_dom", "InterPro-Type": "DOMAIN", "Beg": 1, "End": 123 }, { "InterPro-ID": "IPR035892", "InterPro-Name": "C2_domain_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1209, "End": 1349 } ], "response#1": "MAAKAIQYNIKVDLHEVKDLSFREAAGEKEIVPNPYIEVTVNGVTKTTIQKTQVVSATFNTSFNFTAYLTPDEFARSYVEVAVLHKYMLIGGVGLQSAVIGKYVFSFAYVYTKSQHWIYRQWVTLRNLDQPQDETGLLLITVGVFGPGDAMPVVDETVCVVNEGERTSTDVNVKLTHYSLSVNIFKGQDIPSVAGQFSTVLEPYVKVKHGGAELQTRPLPDSNPDWLASISIPACVPCFDGNVLVELWNGQDSSTAAGTLMGTVVLDYFQLIKNDLPPRWFNFYWRPPAEGLLGAVTDMMASAELREPIAYGGRILLSASAAKVQTPLPLGVRSARPIPDPATQECVWWLDLYEMTSATGYTSELRIEIAFGPHVIKTASLEANALGTYVIGDNLGRLPEMKIFAPVDEVQVWDVMMYVCSPPATTVAAGIADISNWFSGWGGSPTATQNTPEPAETPWTRLAWVRIPYDSRQFQNGKPQWYSLRSLDGSGTDMFSVLLGMEMFPTKAGKQRAPRLEYKLARFYFRALIYEGLHLPAVGYDVFPDPYIQVELASKTLRTSTIRQTLNPSYYEAYEIEIRLPENISLAPDINVEVISESNSLLSSDVVLGSVQYPIQKVPKEWTKAPVWLQLHSKAYPRCKARVLVAFELVPAEKAEDDTYPFYDDIRPSTKEGNIRLFLVGVRLFKPITQPFVTVCFGRDVENTAEPLWSQESSAPRTGEGGNWNFLEEFTVSVSLPKRMQHHSFLEVKIQDRTQGIGGESNVDVGMAYITLNPLLPWLDSRERAESLETFRLQMLEEVLIEDAENARRSADGGLAARTGGGSFDEDATKKKEMLAAERSRKMAIPYNDPDMANLKIEEVDDYVSFKVAPRPQASRLSREGTSRDERGKAPGKSLSGMPGPVARASPGAGEETEKKGDPVAEKKEGGAQAAPPVAPSAHQREALAASPEEETYGFTPEQLNFVLADLEEDDAEEMTRDEVPYELEADFTVDDLPYLRTPIFRPTDAGVPETVGYLKYVCRVFQSTDEDEGAEMDAVCKSLIETYNSTRDLVVRAYVLAARGLVPPSGASDIQTYVWIQDSENAATLPGGLSYNIRDTGYTKKQGFKPEFNRCYTLACSLPENSIVQIAVMNMGRLTDECIGRTYLDVEDRFFNKKVEQMVIEESTPIELRTLKNEGSTVSHGSLRGFFEIMRADYAQLHPPYTLASAEPDEYQLRVVIWRVKAVPLDDNSSISLFVRTIYQLEDSSEIVKDTDTHYNSTDGTAVYNWRMVFDVLIPAQIPVLKLQIWNYALLSSTEPIGEANFDLTADFFRARKRQQHYRVPRMWVRCSHPAHKGKLRGTIEIEASILPREEAEYTPVGNGRDEPNRDPFLPAVTTNRTYIDWQQIGETVGAASSAIMSGLKWTGVWMTVAGIIALVIFVMFLLK", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more C2_dom, C2_dom, C2_dom, C2_dom, C2_dom, C2_dom, C2_dom, C2_dom, C2_dom, C2_dom, FerIin_dom, C2_dom, C2_dom, C2_dom, C2_dom, C2E_Ferlin, C2_dom that are essential for its biological function; 2. The protein should belong to Ferlin that shares evolutionary origin and functional similarity; 3. The protein should be classified within C2_domain_sf, C2_domain_sf, C2_domain_sf, C2_domain_sf, C2_domain_sf, C2_domain_sf, C2_domain_sf, C2_domain_sf, C2_domain_sf, C2_domain_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MAAKAIQYNIKVDLHEVKDLSFREAAGEKEIVPNPYIEVTVNGVTKTTIQKTQVVSATFNTSFNFTAYLTPDEFARSYVEVAVLHKYMLIGGVGLQSAVIGKYVFSFAYVYTKSQHWIYRQWVTLRNLDQPQDETGLLLITVGVFGPGDAMPVVDETVCVVNEGERTSTDVNVKLTHYSLSVNIFKGQDIPSVAGQFSTVLEPYVKVKHGGAELQTRPLPDSNPDWLASISIPACVPCFDGNVLVELWNGQDSSTAAGTLMGTVVLDYFQLIKNDLPPRWFNFYWRPPAEGLLGAVTDMMASAELREPIAYGGRILLSASAAKVQTPLPLGVRSARPIPDPATQECVWWLDLYEMTSATGYTSELRIEIAFGPHVIKTASLEANALGTYVIGDNLGRLPEMKIFAPVDEVQVWDVMMYVCSPPATTVAAGIADISNWFSGWGGSPTATQNTPEPAETPWTRLAWVRIPYDSRQFQNGKPQWYSLRSLDGSGTDMFSVLLGMEMFPTKAGKQRAPRLEYKLARFYFRALIYEGLHLPAVGYDVFPDPYIQVELASKTLRTSTIRQTLNPSYYEAYEIEIRLPENISLAPDINVEVISESNSLLSSDVVLGSVQYPIQKVPKEWTKAPVWLQLHSKAYPRCKARVLVAFELVPAEKAEDDTYPFYDDIRPSTKEGNIRLFLVGVRLFKPITQPFVTVCFGRDVENTAEPLWSQESSAPRTGEGGNWNFLEEFTVSVSLPKRMQHHSFLEVKIQDRTQGIGGESNVDVGMAYITLNPLLPWLDSRERAESLETFRLQMLEEVLIEDAENARRSADGGLAARTGGGSFDEDATKKKEMLAAERSRKMAIPYNDPDMANLKIEEVDDYVSFKVAPRPQASRLSREGTSRDERGKAPGKSLSGMPGPVARASPGAGEETEKKGDPVAEKKEGGAQAAPPVAPSAHQREALAASPEEETYGFTPEQLNFVLADLEEDDAEEMTRDEVPYELEADFTVDDLPYLRTPIFRPTDAGVPETVGYLKYVCRVFQSTDEDEGAEMDAVCKSLIETYNSTRDLVVRAYVLAARGLVPPSGASDIQTYVWIQDSENAATLPGGLSYNIRDTGYTKKQGFKPEFNRCYTLACSLPENSIVQIAVMNMGRLTDECIGRTYLDVEDRFFNKKVEQMVIEESTPIELRTLKNEGSTVSHGSLRGFFEIMRADYAQLHPPYTLASAEPDEYQLRVVIWRVKAVPLDDNSSISLFVRTIYQLEDSSEIVKDTDTHYNSTDGTAVYNWRMVFDVLIPAQIPVLKLQIWNYALLSSTEPIGEANFDLTADFFRARKRQQHYRVPRMWVRCSHPAHKGKLRGTIEIEASILPREEAEYTPVGNGRDEPNRDPFLPAVTTNRTYIDWQQIGETVGAASSAIMSGLKWTGVWMTVAGIIALVIFVMFLLK" }, { "InterPro": [ { "InterPro-ID": "IPR001932", "InterPro-Name": "PPM-type_phosphatase-like_dom", "InterPro-Type": "DOMAIN", "Beg": 23, "End": 298 }, { "InterPro-ID": "IPR001932", "InterPro-Name": "PPM-type_phosphatase-like_dom", "InterPro-Type": "DOMAIN", "Beg": 24, "End": 282 }, { "InterPro-ID": "IPR036457", "InterPro-Name": "PPM-type-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1, "End": 306 }, { "InterPro-ID": "IPR001932", "InterPro-Name": "PPM-type_phosphatase-like_dom", "InterPro-Type": "DOMAIN", "Beg": 41, "End": 298 }, { "InterPro-ID": "IPR000222", "InterPro-Name": "PP2C_BS", "InterPro-Type": "BINDING_SITE", "Beg": 66, "End": 74 }, { "InterPro-ID": "IPR001932", "InterPro-Name": "PPM-type_phosphatase-like_dom", "InterPro-Type": "DOMAIN", "Beg": 13, "End": 296 }, { "InterPro-ID": "IPR015655", "InterPro-Name": "PP2C", "InterPro-Type": "FAMILY", "Beg": 20, "End": 295 }, { "InterPro-ID": "IPR036457", "InterPro-Name": "PPM-type-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 3, "End": 298 } ], "response#1": "MGQTLSEPVVDKTSSEGEDDCCIYGVSAMQGWRISMEDAHAAVLDLHAKYTSPEETSTDPAKRLAFFGVYDGHGGDKVALFAGENVHKIVAKQDSFAKGDIEQALKDGFLATDRAILEDPKYEEEVSGCTAAVSVISKHKIWVANAGDSRSVLGVKGRAKPLSFDHKPQNEGEKARISAAGGFVDFGRVNGNLALSRAIGDFEFKKSPELAPEQQIVTAYPDVTVHELSDDDEFLVIACDGIWDCQSSQAVVEFVRRGIAAKQELYRICENMMDNCLASNSETGGVGCDNMTMIIIGLLNGRTKEECGDAAEFRGPGIRNQFEENPDDYDMENDRARGFSVRSGRIILLGDGTELVPDQNDEELFDQTEEDRDLPSQVQRELPDSARNEREGTPGPQSKTDATSKSEEGSSASTSESTVTPAGSSTSGAPEKSTS", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more PPM-type_phosphatase-like_dom, PPM-type_phosphatase-like_dom, PPM-type_phosphatase-like_dom, PPM-type_phosphatase-like_dom that are essential for its biological function; 2. The protein should belong to PP2C that shares evolutionary origin and functional similarity; 3. The protein should be classified within PPM-type-like_dom_sf, PPM-type-like_dom_sf sharing conserved structural features; 4. The protein should include a PP2C_BS that enables ligand binding under diverse conditions. The designed protein sequence is ", "reference": "MGQTLSEPVVDKTSSEGEDDCCIYGVSAMQGWRISMEDAHAAVLDLHAKYTSPEETSTDPAKRLAFFGVYDGHGGDKVALFAGENVHKIVAKQDSFAKGDIEQALKDGFLATDRAILEDPKYEEEVSGCTAAVSVISKHKIWVANAGDSRSVLGVKGRAKPLSFDHKPQNEGEKARISAAGGFVDFGRVNGNLALSRAIGDFEFKKSPELAPEQQIVTAYPDVTVHELSDDDEFLVIACDGIWDCQSSQAVVEFVRRGIAAKQELYRICENMMDNCLASNSETGGVGCDNMTMIIIGLLNGRTKEECGDAAEFRGPGIRNQFEENPDDYDMENDRARGFSVRSGRIILLGDGTELVPDQNDEELFDQTEEDRDLPSQVQRELPDSARNEREGTPGPQSKTDATSKSEEGSSASTSESTVTPAGSSTSGAPEKSTS" }, { "InterPro": [ { "InterPro-ID": "IPR005331", "InterPro-Name": "Sulfotransferase", "InterPro-Type": "FAMILY", "Beg": 72, "End": 320 }, { "InterPro-ID": "IPR007734", "InterPro-Name": "Heparan_SO4_2-O-STrfase", "InterPro-Type": "FAMILY", "Beg": 18, "End": 332 }, { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 75, "End": 230 }, { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 69, "End": 356 } ], "response#1": "MGLLRIMMPPKLQLLAVVAFAVAMLFLENQIQKLEESRAKLERAIARHEVREIEQRHTMDGPRQDAAVDEEEDIVIIYNRVPKTASTSFTNIAYDLCAKNRYHVLHINTTKNNPVMSLQDQVRFVKNITTWNEMKPGFYHGHISYLDFAKFGVKKKPIYINVIRDPIERLVSYYYFLRFGDDYRPGLRRRKQGDKKTFDECVAEGGSDCAPEKLWLQIPFFCGHSSECWNVGSRWAMDQAKYNLINEYFLVGVTEELEDFIMLLEAALPRFFRGATDLYRTGKKSHLRKTTEKKLPTKQTIAKLQQSDIWKMENEFYEFALEQFQFIRAHAVREKDGDLYILAQNFFYEKIYPKSN", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Sulfotransferase, Heparan_SO4_2-O-STrfase that shares evolutionary origin and functional similarity; 2. The protein should be classified within P-loop_NTPase, P-loop_NTPase sharing conserved structural features. The designed protein sequence is ", "reference": "MGLLRIMMPPKLQLLAVVAFAVAMLFLENQIQKLEESRAKLERAIARHEVREIEQRHTMDGPRQDAAVDEEEDIVIIYNRVPKTASTSFTNIAYDLCAKNRYHVLHINTTKNNPVMSLQDQVRFVKNITTWNEMKPGFYHGHISYLDFAKFGVKKKPIYINVIRDPIERLVSYYYFLRFGDDYRPGLRRRKQGDKKTFDECVAEGGSDCAPEKLWLQIPFFCGHSSECWNVGSRWAMDQAKYNLINEYFLVGVTEELEDFIMLLEAALPRFFRGATDLYRTGKKSHLRKTTEKKLPTKQTIAKLQQSDIWKMENEFYEFALEQFQFIRAHAVREKDGDLYILAQNFFYEKIYPKSN" }, { "InterPro": [ { "InterPro-ID": "IPR032675", "InterPro-Name": "LRR_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 108, "End": 277 } ], "response#1": "MLQRVSRRFPSLRRCGLRTASTVPTNQAQPGEVEEEVSATVKRIRSELAADKQKLKWRTPIGDRPEDWNSKLKLFSNAEQTSDFIVMMQKPIDLSPRNIRQWWENREERIERHMQQFVPERHKILGAELAAAHFILYRGGAVKFINDTHWRRASKDGEFKLPNKFDPRYKVEALRCDNMELYYEGLENLRCLDSLKFLSFHNVKSFDDWCLDRISGGGFPNLEVLDLSCTQITSNGLACLYRFPKLKLLILNDPKETLELELSTVMLEEAMPALKIVGADAIHS", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should be classified within LRR_dom_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MLQRVSRRFPSLRRCGLRTASTVPTNQAQPGEVEEEVSATVKRIRSELAADKQKLKWRTPIGDRPEDWNSKLKLFSNAEQTSDFIVMMQKPIDLSPRNIRQWWENREERIERHMQQFVPERHKILGAELAAAHFILYRGGAVKFINDTHWRRASKDGEFKLPNKFDPRYKVEALRCDNMELYYEGLENLRCLDSLKFLSFHNVKSFDDWCLDRISGGGFPNLEVLDLSCTQITSNGLACLYRFPKLKLLILNDPKETLELELSTVMLEEAMPALKIVGADAIHS" }, { "InterPro": [ { "InterPro-ID": "IPR029058", "InterPro-Name": "AB_hydrolase_fold", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 23, "End": 361 }, { "InterPro-ID": "IPR029058", "InterPro-Name": "AB_hydrolase_fold", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 14, "End": 356 }, { "InterPro-ID": "IPR013744", "InterPro-Name": "SidJ", "InterPro-Type": "FAMILY", "Beg": 8, "End": 362 }, { "InterPro-ID": "IPR013744", "InterPro-Name": "SidJ", "InterPro-Type": "FAMILY", "Beg": 11, "End": 357 } ], "response#1": "MRIRPSPPKKPTPGLLHEYADRLVAFEYSASKGLKPHTLLFISGLGDGLGTVAYLEDIVAALEGSQWSVFSPVISSSYGGWGTSGLGRDTDEMARCIEYIQKYKEGSGVHETERKIVIMGHSTGSQDVLTYISSPNPRHPQPGLDPGHGHRHKRMPPLRPQVDGAIMQAPVSDRQAIQTVLEEGNERHSAKYMRKVVNDAIAYAKKHTYEDYDSLDTIIPLPITAAIGYPASTAVSSRRFLSLTSPDSPDSPGEDDLFSSDLTDERLRKTFGMVRHRGVLKDQKGLLVLYSGNDPSVPAFVDKEGLLRRWRWATDADEKRAYWHGESGIIPGATHTLEGPGQVEQRKELVRRVWMFLADVEGDPRTSCHSARPLS", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to SidJ, SidJ that shares evolutionary origin and functional similarity; 2. The protein should be classified within AB_hydrolase_fold, AB_hydrolase_fold sharing conserved structural features. The designed protein sequence is ", "reference": "MRIRPSPPKKPTPGLLHEYADRLVAFEYSASKGLKPHTLLFISGLGDGLGTVAYLEDIVAALEGSQWSVFSPVISSSYGGWGTSGLGRDTDEMARCIEYIQKYKEGSGVHETERKIVIMGHSTGSQDVLTYISSPNPRHPQPGLDPGHGHRHKRMPPLRPQVDGAIMQAPVSDRQAIQTVLEEGNERHSAKYMRKVVNDAIAYAKKHTYEDYDSLDTIIPLPITAAIGYPASTAVSSRRFLSLTSPDSPDSPGEDDLFSSDLTDERLRKTFGMVRHRGVLKDQKGLLVLYSGNDPSVPAFVDKEGLLRRWRWATDADEKRAYWHGESGIIPGATHTLEGPGQVEQRKELVRRVWMFLADVEGDPRTSCHSARPLS" }, { "InterPro": [ { "InterPro-ID": "IPR051919", "InterPro-Name": "W-dependent_AOR", "InterPro-Type": "FAMILY", "Beg": 1, "End": 608 }, { "InterPro-ID": "IPR013984", "InterPro-Name": "Ald_Fedxn_OxRdtase_dom2", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 256, "End": 446 }, { "InterPro-ID": "IPR036021", "InterPro-Name": "Tungsten_al_ferr_oxy-like_C", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 225, "End": 610 }, { "InterPro-ID": "IPR001203", "InterPro-Name": "OxRdtase_Ald_Fedxn_C", "InterPro-Type": "DOMAIN", "Beg": 245, "End": 608 }, { "InterPro-ID": "IPR013985", "InterPro-Name": "Ald_Fedxn_OxRdtase_dom3", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 447, "End": 608 }, { "InterPro-ID": "IPR036503", "InterPro-Name": "Ald_Fedxn_OxRdtase_N_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1, "End": 223 }, { "InterPro-ID": "IPR013983", "InterPro-Name": "Ald_Fedxn_OxRdtase_N", "InterPro-Type": "DOMAIN", "Beg": 4, "End": 220 }, { "InterPro-ID": "IPR013983", "InterPro-Name": "Ald_Fedxn_OxRdtase_N", "InterPro-Type": "DOMAIN", "Beg": 6, "End": 218 }, { "InterPro-ID": "IPR036503", "InterPro-Name": "Ald_Fedxn_OxRdtase_N_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1, "End": 222 } ], "response#1": "MYAYNGKLLDVDLTREKVKEVELSEDVLKKFYGGRGLGTYILWKELGEKWEKVDPLGEENLLLILTGPLTGYYPGMKTSIVSKSPESNGVVGSVLSSELGLELKAAGYDGIIIRGKAKSPVYLFIHNDTVEIRDATKYWGMGGIELYKTLLKEVHEEIRKKEKLKGVPKEPAMIYIGKGGENKVRFAAIMTKLMHAAGYGGYGAVMGSKNLKAVIAKGSGPLPEVYDKEKMKVLLREFWKELFSMTTFREWGTGAGGYSVGHDRSSEPIRNWQEEYHDNEEISVVNFENRTWIKKYWADYGCPVNCMKISYLRYGPYKGSISDAPDYELQAYMGTNLGIFEPEKIVYLSYLVDELGLDGINTGNILGFAAELYQRGILTKEDLGFELNWGDEKAFAKLLHLIVEKEGIGKILAEGTYRAALKISEIKGIDVTKYAVHVKGIAVGAHGIRSELDYTKDISYAVSVQGGDHTSTAALPAKGYTGELVEAFYDSAVICNFVTKPGFEKIIEFGNALSGFNITPEQWLNEIGLRIIHLQRILLLLGGPDVYWDPRKDDDNPPRFYEPLPSGPVKGKAPNREDIKAKVKQYYEEIGYDEHGIPKEEVLEELGIGEAKREVKRIKKRLNL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more OxRdtase_Ald_Fedxn_C, Ald_Fedxn_OxRdtase_N, Ald_Fedxn_OxRdtase_N that are essential for its biological function; 2. The protein should belong to W-dependent_AOR that shares evolutionary origin and functional similarity; 3. The protein should be classified within Ald_Fedxn_OxRdtase_dom2, Tungsten_al_ferr_oxy-like_C, Ald_Fedxn_OxRdtase_dom3, Ald_Fedxn_OxRdtase_N_sf, Ald_Fedxn_OxRdtase_N_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MYAYNGKLLDVDLTREKVKEVELSEDVLKKFYGGRGLGTYILWKELGEKWEKVDPLGEENLLLILTGPLTGYYPGMKTSIVSKSPESNGVVGSVLSSELGLELKAAGYDGIIIRGKAKSPVYLFIHNDTVEIRDATKYWGMGGIELYKTLLKEVHEEIRKKEKLKGVPKEPAMIYIGKGGENKVRFAAIMTKLMHAAGYGGYGAVMGSKNLKAVIAKGSGPLPEVYDKEKMKVLLREFWKELFSMTTFREWGTGAGGYSVGHDRSSEPIRNWQEEYHDNEEISVVNFENRTWIKKYWADYGCPVNCMKISYLRYGPYKGSISDAPDYELQAYMGTNLGIFEPEKIVYLSYLVDELGLDGINTGNILGFAAELYQRGILTKEDLGFELNWGDEKAFAKLLHLIVEKEGIGKILAEGTYRAALKISEIKGIDVTKYAVHVKGIAVGAHGIRSELDYTKDISYAVSVQGGDHTSTAALPAKGYTGELVEAFYDSAVICNFVTKPGFEKIIEFGNALSGFNITPEQWLNEIGLRIIHLQRILLLLGGPDVYWDPRKDDDNPPRFYEPLPSGPVKGKAPNREDIKAKVKQYYEEIGYDEHGIPKEEVLEELGIGEAKREVKRIKKRLNL" }, { "InterPro": [ { "InterPro-ID": "IPR001138", "InterPro-Name": "Zn2Cys6_DnaBD", "InterPro-Type": "DOMAIN", "Beg": 10, "End": 40 }, { "InterPro-ID": "IPR001138", "InterPro-Name": "Zn2Cys6_DnaBD", "InterPro-Type": "DOMAIN", "Beg": 10, "End": 41 }, { "InterPro-ID": "IPR051089", "InterPro-Name": "prtT", "InterPro-Type": "FAMILY", "Beg": 10, "End": 564 }, { "InterPro-ID": "IPR036864", "InterPro-Name": "Zn2-C6_fun-type_DNA-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 8, "End": 76 }, { "InterPro-ID": "IPR036864", "InterPro-Name": "Zn2-C6_fun-type_DNA-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 7, "End": 50 } ], "response#1": "MDGRGPYGLACQNCAKGKVKCIAMPDGDGCQRCHRLKKPCHPSHGVRKRESQHFQSPLIEEMDAKLDSVLSLLQSVYLQPSSPNGQAQQYKRKASTPELSSPTQPARTSVSESTYILPPGPLTSPDIVDAEGALNRFREEVLRFCPFLYLPPGLTARQLQQERPFLFETILSVMTRSVQEKMNWSKRIKSTIAHSMVMENESNIDLLLGLLVYACWSQDHYLKRMPTLTRIVELAVSVVMDLNLNKPPPPDAHRLTELGGGNDPNWTRKGPKIRTAEEKRAVLGCFFVSSIISSYFYQMDAMRWTLQMEEDLGSLAASPEWPGDAALAVHVRLQLLAENARKLRDEHGTKPVHIPFFLKSFRFELEAIRNSIPPDLQKDDTILSQLHYVELSIHETAFTANVIPHSINTNNPIGPDAVDCMWHSLLAIKSWDTIYRRMPPDDHTRWSIIQWIHLSRAVVTLYRLSTHPAPDWNRDAVYKTLNIVDVFTHIRASFDQLVPNPGGPFPNDFWAHGWLLGRAIATWLHAPGRLHPPNTDEPTAWAQTSSSHNGEQVLPTWNPPAPALQPQPIQESLQFTNPAWMDGLGLPPGDPTGGMHQAAGLHPTGQMHF", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Zn2Cys6_DnaBD, Zn2Cys6_DnaBD that are essential for its biological function; 2. The protein should belong to prtT that shares evolutionary origin and functional similarity; 3. The protein should be classified within Zn2-C6_fun-type_DNA-bd_sf, Zn2-C6_fun-type_DNA-bd_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MDGRGPYGLACQNCAKGKVKCIAMPDGDGCQRCHRLKKPCHPSHGVRKRESQHFQSPLIEEMDAKLDSVLSLLQSVYLQPSSPNGQAQQYKRKASTPELSSPTQPARTSVSESTYILPPGPLTSPDIVDAEGALNRFREEVLRFCPFLYLPPGLTARQLQQERPFLFETILSVMTRSVQEKMNWSKRIKSTIAHSMVMENESNIDLLLGLLVYACWSQDHYLKRMPTLTRIVELAVSVVMDLNLNKPPPPDAHRLTELGGGNDPNWTRKGPKIRTAEEKRAVLGCFFVSSIISSYFYQMDAMRWTLQMEEDLGSLAASPEWPGDAALAVHVRLQLLAENARKLRDEHGTKPVHIPFFLKSFRFELEAIRNSIPPDLQKDDTILSQLHYVELSIHETAFTANVIPHSINTNNPIGPDAVDCMWHSLLAIKSWDTIYRRMPPDDHTRWSIIQWIHLSRAVVTLYRLSTHPAPDWNRDAVYKTLNIVDVFTHIRASFDQLVPNPGGPFPNDFWAHGWLLGRAIATWLHAPGRLHPPNTDEPTAWAQTSSSHNGEQVLPTWNPPAPALQPQPIQESLQFTNPAWMDGLGLPPGDPTGGMHQAAGLHPTGQMHF" }, { "InterPro": [ { "InterPro-ID": "IPR001138", "InterPro-Name": "Zn2Cys6_DnaBD", "InterPro-Type": "DOMAIN", "Beg": 19, "End": 63 }, { "InterPro-ID": "IPR001138", "InterPro-Name": "Zn2Cys6_DnaBD", "InterPro-Type": "DOMAIN", "Beg": 24, "End": 61 }, { "InterPro-ID": "IPR001138", "InterPro-Name": "Zn2Cys6_DnaBD", "InterPro-Type": "DOMAIN", "Beg": 24, "End": 52 }, { "InterPro-ID": "IPR001138", "InterPro-Name": "Zn2Cys6_DnaBD", "InterPro-Type": "DOMAIN", "Beg": 24, "End": 54 }, { "InterPro-ID": "IPR050815", "InterPro-Name": "TF_fung", "InterPro-Type": "FAMILY", "Beg": 16, "End": 535 }, { "InterPro-ID": "IPR036864", "InterPro-Name": "Zn2-C6_fun-type_DNA-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 17, "End": 78 }, { "InterPro-ID": "IPR007219", "InterPro-Name": "Transcription_factor_dom_fun", "InterPro-Type": "DOMAIN", "Beg": 302, "End": 379 }, { "InterPro-ID": "IPR036864", "InterPro-Name": "Zn2-C6_fun-type_DNA-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 15, "End": 63 }, { "InterPro-ID": "IPR007219", "InterPro-Name": "Transcription_factor_dom_fun", "InterPro-Type": "DOMAIN", "Beg": 204, "End": 389 }, { "InterPro-ID": "IPR001138", "InterPro-Name": "Zn2Cys6_DnaBD", "InterPro-Type": "DOMAIN", "Beg": 24, "End": 53 } ], "response#1": "MPQKAQPQPRESPFKPARQQPGLACEECRKRKARCDRAKPQCGSCMMTGRVCVVNHNRPRRGPKKGQIESLYSRLGRFIHGSLCISCWKAGMLTVTEVLEEQVIEQMEHIYHPDFEPNSHPRHSQSHDRRQQSGPDSSPDTQHELPFLQSPPAARDADSAERALLPSPVSPVRAMTAQELSYARTGSNPTQNPGLDLILADLDQLYFDRVHPIAPFLHQQRHLSQREAESSVLARACLRSAMRTVAAAMSAQYRRFADSLYIETSRVVQELDTIERTPSLKQIQAVLLLAHYELLRMEENRALATVGRCFRLIQLARLQDTDPSTDAGAGRDFVKEEETRRTFWVAYCFDRFLTSRNEWPFTLQEEAIWIRLPVSESAFQIPRPPEQPMDYLHEAIASSGQKTLPPFAEYIVLATLHGRTMNLRRSALLLSTSTEASMFWERHRALSDIVEKRSALWSYSPSATTPLVTADPLTAFTCLLEKTLIIYLGKVGQTAREQLGGMSERRLIENANSAVQNLATSEQETLMNCHSHSRSFDIGTGGRGGHASGGLQRSAQTAAEFVALAKFMCPVNCFRICSDKSVRRLTLSFQMQYPAQQSFLLRMEMPPRLEKYGMNVGERGTGRIRAIDHASRLKVDERRAVRAYL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Zn2Cys6_DnaBD, Zn2Cys6_DnaBD, Zn2Cys6_DnaBD, Zn2Cys6_DnaBD, Transcription_factor_dom_fun, Transcription_factor_dom_fun, Zn2Cys6_DnaBD that are essential for its biological function; 2. The protein should belong to TF_fung that shares evolutionary origin and functional similarity; 3. The protein should be classified within Zn2-C6_fun-type_DNA-bd_sf, Zn2-C6_fun-type_DNA-bd_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MPQKAQPQPRESPFKPARQQPGLACEECRKRKARCDRAKPQCGSCMMTGRVCVVNHNRPRRGPKKGQIESLYSRLGRFIHGSLCISCWKAGMLTVTEVLEEQVIEQMEHIYHPDFEPNSHPRHSQSHDRRQQSGPDSSPDTQHELPFLQSPPAARDADSAERALLPSPVSPVRAMTAQELSYARTGSNPTQNPGLDLILADLDQLYFDRVHPIAPFLHQQRHLSQREAESSVLARACLRSAMRTVAAAMSAQYRRFADSLYIETSRVVQELDTIERTPSLKQIQAVLLLAHYELLRMEENRALATVGRCFRLIQLARLQDTDPSTDAGAGRDFVKEEETRRTFWVAYCFDRFLTSRNEWPFTLQEEAIWIRLPVSESAFQIPRPPEQPMDYLHEAIASSGQKTLPPFAEYIVLATLHGRTMNLRRSALLLSTSTEASMFWERHRALSDIVEKRSALWSYSPSATTPLVTADPLTAFTCLLEKTLIIYLGKVGQTAREQLGGMSERRLIENANSAVQNLATSEQETLMNCHSHSRSFDIGTGGRGGHASGGLQRSAQTAAEFVALAKFMCPVNCFRICSDKSVRRLTLSFQMQYPAQQSFLLRMEMPPRLEKYGMNVGERGTGRIRAIDHASRLKVDERRAVRAYL" }, { "InterPro": [ { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 231, "End": 383 }, { "InterPro-ID": "IPR036396", "InterPro-Name": "Cyt_P450_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 14, "End": 414 }, { "InterPro-ID": "IPR017972", "InterPro-Name": "Cyt_P450_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 356, "End": 365 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 285, "End": 296 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 354, "End": 363 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 248, "End": 265 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 363, "End": 374 }, { "InterPro-ID": "IPR002397", "InterPro-Name": "Cyt_P450_B", "InterPro-Type": "FAMILY", "Beg": 102, "End": 113 }, { "InterPro-ID": "IPR002397", "InterPro-Name": "Cyt_P450_B", "InterPro-Type": "FAMILY", "Beg": 354, "End": 363 }, { "InterPro-ID": "IPR002397", "InterPro-Name": "Cyt_P450_B", "InterPro-Type": "FAMILY", "Beg": 166, "End": 181 }, { "InterPro-ID": "IPR002397", "InterPro-Name": "Cyt_P450_B", "InterPro-Type": "FAMILY", "Beg": 285, "End": 296 }, { "InterPro-ID": "IPR002397", "InterPro-Name": "Cyt_P450_B", "InterPro-Type": "FAMILY", "Beg": 149, "End": 165 }, { "InterPro-ID": "IPR002397", "InterPro-Name": "Cyt_P450_B", "InterPro-Type": "FAMILY", "Beg": 303, "End": 330 }, { "InterPro-ID": "IPR002397", "InterPro-Name": "Cyt_P450_B", "InterPro-Type": "FAMILY", "Beg": 203, "End": 225 }, { "InterPro-ID": "IPR002397", "InterPro-Name": "Cyt_P450_B", "InterPro-Type": "FAMILY", "Beg": 363, "End": 374 }, { "InterPro-ID": "IPR036396", "InterPro-Name": "Cyt_P450_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 26, "End": 414 } ], "response#1": "MTDTTLVEAGDPAEDAPEWPMKRDTGCPFDPPPGVRKLLAEKPLSRARIWDGSTPWVVTRHADQRALLSDPRVSHDGLRDGYPHISADFKFLSMAQPSFAGQDDPEHGRIRRMVTLPFTARRIEAMRPAIQKITDELIDGMLAGPKPVDLVEALALPVPVRVICEMLGVPYEDREFLQQNNNAMIYRDTAQGDAQKAAIAQAMYLKELVGTKLGDRGDDILSDLAVQVEAGEITQDDAAGIGMMLLGAGHETTANMIALGTLALLENPEQLAEVRDSDDPKVIVNTVEELLRYLTIAQDTVRRIAAEDIEIGGVVIKAGEGIVFPLNAANWDPDLYPEAPDRLDIHRANARRHLAFGYGVHQCLGATLARVELQIVYSTLLRRIPTLALAGTLDEIPFKHDQIAHGVYELPVTW", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Cyt_P450, Cyt_P450, Cyt_P450, Cyt_P450, Cyt_P450, Cyt_P450_B, Cyt_P450_B, Cyt_P450_B, Cyt_P450_B, Cyt_P450_B, Cyt_P450_B, Cyt_P450_B, Cyt_P450_B that shares evolutionary origin and functional similarity; 2. The protein should be classified within Cyt_P450_sf, Cyt_P450_sf sharing conserved structural features; 3. The protein should contain Cyt_P450_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MTDTTLVEAGDPAEDAPEWPMKRDTGCPFDPPPGVRKLLAEKPLSRARIWDGSTPWVVTRHADQRALLSDPRVSHDGLRDGYPHISADFKFLSMAQPSFAGQDDPEHGRIRRMVTLPFTARRIEAMRPAIQKITDELIDGMLAGPKPVDLVEALALPVPVRVICEMLGVPYEDREFLQQNNNAMIYRDTAQGDAQKAAIAQAMYLKELVGTKLGDRGDDILSDLAVQVEAGEITQDDAAGIGMMLLGAGHETTANMIALGTLALLENPEQLAEVRDSDDPKVIVNTVEELLRYLTIAQDTVRRIAAEDIEIGGVVIKAGEGIVFPLNAANWDPDLYPEAPDRLDIHRANARRHLAFGYGVHQCLGATLARVELQIVYSTLLRRIPTLALAGTLDEIPFKHDQIAHGVYELPVTW" }, { "InterPro": [ { "InterPro-ID": "IPR020841", "InterPro-Name": "PKS_Beta-ketoAc_synthase_dom", "InterPro-Type": "DOMAIN", "Beg": 4084, "End": 4514 }, { "InterPro-ID": "IPR018201", "InterPro-Name": "Ketoacyl_synth_AS", "InterPro-Type": "ACTIVE_SITE", "Beg": 4252, "End": 4268 }, { "InterPro-ID": "IPR009081", "InterPro-Name": "PP-bd_ACP", "InterPro-Type": "DOMAIN", "Beg": 945, "End": 1020 }, { "InterPro-ID": "IPR014043", "InterPro-Name": "Acyl_transferase_dom", "InterPro-Type": "DOMAIN", "Beg": 4630, "End": 4921 }, { "InterPro-ID": "IPR014043", "InterPro-Name": "Acyl_transferase_dom", "InterPro-Type": "DOMAIN", "Beg": 565, "End": 856 }, { "InterPro-ID": "IPR014043", "InterPro-Name": "Acyl_transferase_dom", "InterPro-Type": "DOMAIN", "Beg": 6190, "End": 6511 }, { "InterPro-ID": "IPR014043", "InterPro-Name": "Acyl_transferase_dom", "InterPro-Type": "DOMAIN", "Beg": 3070, "End": 3385 }, { "InterPro-ID": "IPR014043", "InterPro-Name": "Acyl_transferase_dom", "InterPro-Type": "DOMAIN", "Beg": 1563, "End": 1886 }, { "InterPro-ID": "IPR036291", "InterPro-Name": "NAD(P)-bd_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 5277, "End": 5519 }, { "InterPro-ID": "IPR016036", "InterPro-Name": "Malonyl_transacylase_ACP-bd", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 3194, "End": 3259 }, { "InterPro-ID": "IPR036291", "InterPro-Name": "NAD(P)-bd_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 3708, "End": 3956 }, { "InterPro-ID": "IPR009081", "InterPro-Name": "PP-bd_ACP", "InterPro-Type": "DOMAIN", "Beg": 5561, "End": 5636 }, { "InterPro-ID": "IPR020841", "InterPro-Name": "PKS_Beta-ketoAc_synthase_dom", "InterPro-Type": "DOMAIN", "Beg": 1038, "End": 1454 }, { "InterPro-ID": "IPR020841", "InterPro-Name": "PKS_Beta-ketoAc_synthase_dom", "InterPro-Type": "DOMAIN", "Beg": 5655, "End": 6081 }, { "InterPro-ID": "IPR036291", "InterPro-Name": "NAD(P)-bd_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 5050, "End": 5266 }, { "InterPro-ID": "IPR020807", "InterPro-Name": "PKS_DH", "InterPro-Type": "DOMAIN", "Beg": 6561, "End": 6726 }, { "InterPro-ID": "IPR016039", "InterPro-Name": "Thiolase-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1036, "End": 1402 }, { "InterPro-ID": "IPR016035", "InterPro-Name": "Acyl_Trfase/lysoPLipase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 3067, "End": 3355 }, { "InterPro-ID": "IPR036736", "InterPro-Name": "ACP-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 3969, "End": 4066 }, { "InterPro-ID": "IPR036736", "InterPro-Name": "ACP-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 937, "End": 1023 }, { "InterPro-ID": "IPR036736", "InterPro-Name": "ACP-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 5542, "End": 5640 }, { "InterPro-ID": "IPR036736", "InterPro-Name": "ACP-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 7305, "End": 7402 }, { "InterPro-ID": "IPR036736", "InterPro-Name": "ACP-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 2422, "End": 2521 }, { "InterPro-ID": "IPR016035", "InterPro-Name": "Acyl_Trfase/lysoPLipase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 4627, "End": 4923 }, { "InterPro-ID": "IPR036291", "InterPro-Name": "NAD(P)-bd_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 6847, "End": 7025 }, { "InterPro-ID": "IPR006162", "InterPro-Name": "Ppantetheine_attach_site", "InterPro-Type": "PTM", "Beg": 7355, "End": 7370 }, { "InterPro-ID": "IPR009081", "InterPro-Name": "PP-bd_ACP", "InterPro-Type": "DOMAIN", "Beg": 2442, "End": 2517 }, { "InterPro-ID": "IPR016036", "InterPro-Name": "Malonyl_transacylase_ACP-bd", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 697, "End": 761 }, { "InterPro-ID": "IPR016039", "InterPro-Name": "Thiolase-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 23, "End": 449 }, { "InterPro-ID": "IPR016039", "InterPro-Name": "Thiolase-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 2537, "End": 2962 }, { "InterPro-ID": "IPR016035", "InterPro-Name": "Acyl_Trfase/lysoPLipase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1561, "End": 1852 }, { "InterPro-ID": "IPR041618", "InterPro-Name": "PKS_DE", "InterPro-Type": "DOMAIN", "Beg": 5003, "End": 5044 }, { "InterPro-ID": "IPR041618", "InterPro-Name": "PKS_DE", "InterPro-Type": "DOMAIN", "Beg": 3434, "End": 3484 }, { "InterPro-ID": "IPR013968", "InterPro-Name": "PKS_KR", "InterPro-Type": "DOMAIN", "Beg": 3712, "End": 3887 }, { "InterPro-ID": "IPR013968", "InterPro-Name": "PKS_KR", "InterPro-Type": "DOMAIN", "Beg": 7038, "End": 7216 }, { "InterPro-ID": "IPR013968", "InterPro-Name": "PKS_KR", "InterPro-Type": "DOMAIN", "Beg": 5281, "End": 5459 }, { "InterPro-ID": "IPR013968", "InterPro-Name": "PKS_KR", "InterPro-Type": "DOMAIN", "Beg": 2160, "End": 2337 }, { "InterPro-ID": "IPR036736", "InterPro-Name": "ACP-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 2441, "End": 2554 }, { "InterPro-ID": "IPR020841", "InterPro-Name": "PKS_Beta-ketoAc_synthase_dom", "InterPro-Type": "DOMAIN", "Beg": 26, "End": 451 }, { "InterPro-ID": "IPR036736", "InterPro-Name": "ACP-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 3986, "End": 4100 }, { "InterPro-ID": "IPR032821", "InterPro-Name": "PKS_assoc", "InterPro-Type": "DOMAIN", "Beg": 401, "End": 503 }, { "InterPro-ID": "IPR032821", "InterPro-Name": "PKS_assoc", "InterPro-Type": "DOMAIN", "Beg": 1407, "End": 1526 }, { "InterPro-ID": "IPR032821", "InterPro-Name": "PKS_assoc", "InterPro-Type": "DOMAIN", "Beg": 2917, "End": 3034 }, { "InterPro-ID": "IPR032821", "InterPro-Name": "PKS_assoc", "InterPro-Type": "DOMAIN", "Beg": 6034, "End": 6153 }, { "InterPro-ID": "IPR032821", "InterPro-Name": "PKS_assoc", "InterPro-Type": "DOMAIN", "Beg": 4467, "End": 4592 }, { "InterPro-ID": "IPR049900", "InterPro-Name": "PKS_mFAS_DH", "InterPro-Type": "DOMAIN", "Beg": 6561, "End": 6841 }, { "InterPro-ID": "IPR014030", "InterPro-Name": "Ketoacyl_synth_N", "InterPro-Type": "DOMAIN", "Beg": 2539, "End": 2789 }, { "InterPro-ID": "IPR014030", "InterPro-Name": "Ketoacyl_synth_N", "InterPro-Type": "DOMAIN", "Beg": 5656, "End": 5906 }, { "InterPro-ID": "IPR014030", "InterPro-Name": "Ketoacyl_synth_N", "InterPro-Type": "DOMAIN", "Beg": 27, "End": 275 }, { "InterPro-ID": "IPR014030", "InterPro-Name": "Ketoacyl_synth_N", "InterPro-Type": "DOMAIN", "Beg": 1039, "End": 1279 }, { "InterPro-ID": "IPR014030", "InterPro-Name": "Ketoacyl_synth_N", "InterPro-Type": "DOMAIN", "Beg": 4085, "End": 4339 }, { "InterPro-ID": "IPR036736", "InterPro-Name": "ACP-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 945, "End": 1054 }, { "InterPro-ID": "IPR036291", "InterPro-Name": "NAD(P)-bd_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 3486, "End": 3698 }, { "InterPro-ID": "IPR006162", "InterPro-Name": "Ppantetheine_attach_site", "InterPro-Type": "PTM", "Beg": 5591, "End": 5606 }, { "InterPro-ID": "IPR018201", "InterPro-Name": "Ketoacyl_synth_AS", "InterPro-Type": "ACTIVE_SITE", "Beg": 5819, "End": 5835 }, { "InterPro-ID": "IPR036291", "InterPro-Name": "NAD(P)-bd_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1936, "End": 2144 }, { "InterPro-ID": "IPR049551", "InterPro-Name": "PKS_DH_C", "InterPro-Type": "DOMAIN", "Beg": 6689, "End": 6838 }, { "InterPro-ID": "IPR016036", "InterPro-Name": "Malonyl_transacylase_ACP-bd", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 4762, "End": 4826 }, { "InterPro-ID": "IPR009081", "InterPro-Name": "PP-bd_ACP", "InterPro-Type": "DOMAIN", "Beg": 3993, "End": 4059 }, { "InterPro-ID": "IPR009081", "InterPro-Name": "PP-bd_ACP", "InterPro-Type": "DOMAIN", "Beg": 2447, "End": 2513 }, { "InterPro-ID": "IPR009081", "InterPro-Name": "PP-bd_ACP", "InterPro-Type": "DOMAIN", "Beg": 949, "End": 1016 }, { "InterPro-ID": "IPR009081", "InterPro-Name": "PP-bd_ACP", "InterPro-Type": "DOMAIN", "Beg": 5566, "End": 5632 }, { "InterPro-ID": "IPR009081", "InterPro-Name": "PP-bd_ACP", "InterPro-Type": "DOMAIN", "Beg": 7330, "End": 7396 }, { "InterPro-ID": "IPR014031", "InterPro-Name": "Ketoacyl_synth_C", "InterPro-Type": "DOMAIN", "Beg": 283, "End": 398 }, { "InterPro-ID": "IPR014031", "InterPro-Name": "Ketoacyl_synth_C", "InterPro-Type": "DOMAIN", "Beg": 5914, "End": 6031 }, { "InterPro-ID": "IPR014031", "InterPro-Name": "Ketoacyl_synth_C", "InterPro-Type": "DOMAIN", "Beg": 4347, "End": 4464 }, { "InterPro-ID": "IPR014031", "InterPro-Name": "Ketoacyl_synth_C", "InterPro-Type": "DOMAIN", "Beg": 2797, "End": 2915 }, { "InterPro-ID": "IPR014031", "InterPro-Name": "Ketoacyl_synth_C", "InterPro-Type": "DOMAIN", "Beg": 1287, "End": 1404 }, { "InterPro-ID": "IPR016039", "InterPro-Name": "Thiolase-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 4082, "End": 4453 }, { "InterPro-ID": "IPR018201", "InterPro-Name": "Ketoacyl_synth_AS", "InterPro-Type": "ACTIVE_SITE", "Beg": 1192, "End": 1208 }, { "InterPro-ID": "IPR016035", "InterPro-Name": "Acyl_Trfase/lysoPLipase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 562, "End": 858 }, { "InterPro-ID": "IPR016039", "InterPro-Name": "Thiolase-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1030, "End": 1475 }, { "InterPro-ID": "IPR016039", "InterPro-Name": "Thiolase-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 5650, "End": 6099 }, { "InterPro-ID": "IPR016039", "InterPro-Name": "Thiolase-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 18, "End": 468 }, { "InterPro-ID": "IPR016039", "InterPro-Name": "Thiolase-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 2532, "End": 2981 }, { "InterPro-ID": "IPR016039", "InterPro-Name": "Thiolase-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 4076, "End": 4538 }, { "InterPro-ID": "IPR006162", "InterPro-Name": "Ppantetheine_attach_site", "InterPro-Type": "PTM", "Beg": 2472, "End": 2487 }, { "InterPro-ID": "IPR014043", "InterPro-Name": "Acyl_transferase_dom", "InterPro-Type": "DOMAIN", "Beg": 6191, "End": 6493 }, { "InterPro-ID": "IPR014043", "InterPro-Name": "Acyl_transferase_dom", "InterPro-Type": "DOMAIN", "Beg": 4630, "End": 4935 }, { "InterPro-ID": "IPR014043", "InterPro-Name": "Acyl_transferase_dom", "InterPro-Type": "DOMAIN", "Beg": 3071, "End": 3368 }, { "InterPro-ID": "IPR014043", "InterPro-Name": "Acyl_transferase_dom", "InterPro-Type": "DOMAIN", "Beg": 565, "End": 870 }, { "InterPro-ID": "IPR014043", "InterPro-Name": "Acyl_transferase_dom", "InterPro-Type": "DOMAIN", "Beg": 1565, "End": 1868 }, { "InterPro-ID": "IPR001227", "InterPro-Name": "Ac_transferase_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1563, "End": 1871 }, { "InterPro-ID": "IPR001227", "InterPro-Name": "Ac_transferase_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 3069, "End": 3371 }, { "InterPro-ID": "IPR001227", "InterPro-Name": "Ac_transferase_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 6189, "End": 6496 }, { "InterPro-ID": "IPR001227", "InterPro-Name": "Ac_transferase_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 563, "End": 873 }, { "InterPro-ID": "IPR001227", "InterPro-Name": "Ac_transferase_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 4628, "End": 4938 }, { "InterPro-ID": "IPR020841", "InterPro-Name": "PKS_Beta-ketoAc_synthase_dom", "InterPro-Type": "DOMAIN", "Beg": 2538, "End": 2964 }, { "InterPro-ID": "IPR036291", "InterPro-Name": "NAD(P)-bd_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 7037, "End": 7243 }, { "InterPro-ID": "IPR049552", "InterPro-Name": "PKS_DH_N", "InterPro-Type": "DOMAIN", "Beg": 6561, "End": 6661 }, { "InterPro-ID": "IPR016036", "InterPro-Name": "Malonyl_transacylase_ACP-bd", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 6318, "End": 6383 }, { "InterPro-ID": "IPR036736", "InterPro-Name": "ACP-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 7321, "End": 7404 }, { "InterPro-ID": "IPR020806", "InterPro-Name": "PKS_PP-bd", "InterPro-Type": "DOMAIN", "Beg": 5564, "End": 5636 }, { "InterPro-ID": "IPR020806", "InterPro-Name": "PKS_PP-bd", "InterPro-Type": "DOMAIN", "Beg": 3991, "End": 4063 }, { "InterPro-ID": "IPR020806", "InterPro-Name": "PKS_PP-bd", "InterPro-Type": "DOMAIN", "Beg": 2445, "End": 2517 }, { "InterPro-ID": "IPR020806", "InterPro-Name": "PKS_PP-bd", "InterPro-Type": "DOMAIN", "Beg": 948, "End": 1020 }, { "InterPro-ID": "IPR020806", "InterPro-Name": "PKS_PP-bd", "InterPro-Type": "DOMAIN", "Beg": 7328, "End": 7400 }, { "InterPro-ID": "IPR009081", "InterPro-Name": "PP-bd_ACP", "InterPro-Type": "DOMAIN", "Beg": 7325, "End": 7400 }, { "InterPro-ID": "IPR009081", "InterPro-Name": "PP-bd_ACP", "InterPro-Type": "DOMAIN", "Beg": 3988, "End": 4063 }, { "InterPro-ID": "IPR016039", "InterPro-Name": "Thiolase-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 5654, "End": 6029 }, { "InterPro-ID": "IPR020841", "InterPro-Name": "PKS_Beta-ketoAc_synthase_dom", "InterPro-Type": "DOMAIN", "Beg": 4087, "End": 4517 }, { "InterPro-ID": "IPR020841", "InterPro-Name": "PKS_Beta-ketoAc_synthase_dom", "InterPro-Type": "DOMAIN", "Beg": 5658, "End": 6084 }, { "InterPro-ID": "IPR020841", "InterPro-Name": "PKS_Beta-ketoAc_synthase_dom", "InterPro-Type": "DOMAIN", "Beg": 1041, "End": 1457 }, { "InterPro-ID": "IPR020841", "InterPro-Name": "PKS_Beta-ketoAc_synthase_dom", "InterPro-Type": "DOMAIN", "Beg": 2541, "End": 2967 }, { "InterPro-ID": "IPR020841", "InterPro-Name": "PKS_Beta-ketoAc_synthase_dom", "InterPro-Type": "DOMAIN", "Beg": 29, "End": 454 }, { "InterPro-ID": "IPR016035", "InterPro-Name": "Acyl_Trfase/lysoPLipase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 6189, "End": 6482 }, { "InterPro-ID": "IPR036736", "InterPro-Name": "ACP-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 5558, "End": 5671 }, { "InterPro-ID": "IPR018201", "InterPro-Name": "Ketoacyl_synth_AS", "InterPro-Type": "ACTIVE_SITE", "Beg": 2702, "End": 2718 }, { "InterPro-ID": "IPR042104", "InterPro-Name": "PKS_dehydratase_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 6550, "End": 6844 }, { "InterPro-ID": "IPR050091", "InterPro-Name": "PKS_NRPS_Biosynth_Enz", "InterPro-Type": "FAMILY", "Beg": 936, "End": 1018 }, { "InterPro-ID": "IPR016036", "InterPro-Name": "Malonyl_transacylase_ACP-bd", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1692, "End": 1758 }, { "InterPro-ID": "IPR036291", "InterPro-Name": "NAD(P)-bd_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 2156, "End": 2398 }, { "InterPro-ID": "IPR006162", "InterPro-Name": "Ppantetheine_attach_site", "InterPro-Type": "PTM", "Beg": 975, "End": 990 } ], "response#1": "MNHIPVNRGVCLMGRSQNSEFETASDEPIAVIGLSCRLPKASGPQELWQLLDDGASAVTRVPADRETPPSTEEESADGEAAGARWGGFLDRVDTFDAGFFGISPREAAAMDPQQRLVLELSWEALEGAGLVPATLRDTGLGVFVGAARDDYATLYRRREGRAVDHHAMTGLHRSLIANRISYALGAHGPSMVVDTGQSSSLVAVHLACESLRRGESDIALAGGVNLNIAAESARETAAFGGLSPDGQCFTFDARANGFVRGEGGGLVVLKTLRRALADGDLVHGVILASAVNNDGPSDTLTTPSRRAQESLLTRVYRRAGVTPTEVGYVELHGTGTKVGDPIEAAALGAVLGTGRDTPLPVGSIKTNIGHLEGAAGIAGLIKALLQLRRRRLVPSLNFSTPNPDIPLDALNLRVQQESAPWATPSGGGRTLVAGVSSFGMGGTNCHVVVSAAPVPEDGETTSEAGATGPDSGPALLPWVVSARSPQALRDQAGRLAAWADSPAGREASPVDIGWSLATSRTHFEYRAVVSGSDRDELVASLRALASGSPVTAAGAVDGGGRLGLVFSGQGSQRAGMGRELYVAFPVFAEAFDEVCGVLDEVMGALPPSEGWAGSLREVMFEVSSDLLDETGFTQPALFAFEVALYRLLESWGVAGEVVAGHSVGEIAAVHVAGVLSLADACALVAARGRLMQGLPSGGAMVAVEASEEEVTALLAGREGEVGIGAVNGPRSVVVSGGVAVVEEVAAHFAGLGRRARRLKVSHAFHSPLMDPMLEDFGRVVAGLSFAVPELTVVSGLTGAVVSADELCSVGYWVRHAREAVRFADAVGAMAGVGVGRFVEVGPGGVLSALVRECLAEGGAGSVVAAVRGNRAEPVALLSAVGELFADGYPVDWTAYFAGWPAARVELPTYAFQRSRHWLENVPELAVSTTPPAVPREPVTPDSDHPDPVETVRQLTAHVLGLTAAADVEMTRSFKDLGFDSLMSVELRDRLCAATGLSLATTLLYDHPSPAETAEFVRARLTGDEAAAVEVVAARAVEDEPIAVVAMSCRFPGGVRTPEDLWELVRDRVDAVSVFPSDRGWNADAGLFPPAGGFLYDGHHFDAEFFGISPREALAMDPQQRLLLETSWEAFERAGIDPVSLRGSRTGVFVGATAQDYTPKLGEPADGLEGHLLTGGTVSVASGRISYFLGLEGPAVTVDTACSSSLVSLHLACRSLRQGETTLALAGGVTLMATPGMFAEFSRQGGLAADGRCKAFAEAADGTGWAEGVGLVLLERLSDARRNGHPVLAVVRGSAVNQDGASNGLTAPNGPSQQRVIRQALADARLAPADVDLMEAHGTGTRLGDPIEAQALLATYGQGRSGDRPLWLGSVKSNIGHTQAAAGVAGLIKTVMAMRHGTMPATLHVDRPSSHVDWSTGAVELLTEAQPWPDTERPRRAAVSSFGVSGTNAHVILEQATEPAALDAAPDAIVSDAVVAWPLSARDVGALREQAVRLVARVTGDPYVRPADVGHSLAATRSSFEHRAVVVGRERAELLAGLEALASGETAANLATGRASADGAGKVVFVFPGQGSQWPGMGLELAAHSPVFAAVLEDCGRALAAYVDWDGHTLHEVLAQEDGAPSLERVDVVQPALWAVMVALAALWRSHGVQPDAVVGHSQGEIAAACVAGALTLDEAAQVVSLRSRAITALAGAGQMVSVPLPEADTAEWIRPWADAGQIGIAAVNGPGSTVVSGDSAAMDELMEALAAQDVRARRIPVDYASHSPQVARIRDELLHALDGLTPRPATVPVFSTVTGEWLDDTTPMDAEYWYRNLRQTVRFEEAVRALADSGCGVFIEASPHPVLTIGVQETLDVLDRTGVVTGSLRRQKGGPDRFLSSLAQVHTHGGRVDWDTVFAGTGATRTDLPTYPFQRHRYWLERPQAPAVAPAASPAASVSETDSTRYRVVFKPLPEPTAARLSGTWLLVVPDTDEPDARVDAVTGALVTAGATVERIVVEAGADRADLAELLAALATDVGGVRGVVSLLALSEDADAMRPSVPSGLASTLTLVQALGDADVSAPLWCLTRGAVSVGASDRLDSPVQALVWGLGRAAAVEHPERWGGLLDLPATLTGRVLDRLVGVLAADGDEDQVAVRAAGVFGRRLVRGNSAPTRIDHSWQAGGTVLVTGGTGALGARVARWLVDSGAEHVVVASRQGADAPGADRLRDELTGLGARVTPVACDVSDRSAVAELVDRCAEQGDPIRAVVHTAGVGVTKPLADTTPDDLAVSFDAKVAGATHLADALGADLDAFVLFSSAAGVWGSGGQGAYGAANAYLDALAAQRAADGLAATAVAWGPWDGGGMSADAAVIDMDALRRSGLTAMDPDRAIDALDRALTDGETALTVVDVDWTRFAEVFTTARRSPLLADLPEAARLVGPAPTARENSSPVAARLAKASSAAEGRRVLLDLVRGRVADVLGHATPDTIRADRPFKDLGFNSLMTLELRSGLNEATGLRLSATTLFDHPTPSALAEHLAGELLGTPRAEAGPEMPATAPEVTEDPIAIVAMSCRFPGGVGSPEALWRLVADRRDVISGMPADRGWDIDGIYDPVPGVPGRTYTRQGGFLDGVGEFDAEFFGISPREATAMDPQQRLLLETSWEAFERAGIDPTQLRGDSVGVFVGCTGQDYVPRLHETSDELGGYALTGAAGSVASGRVAYTFGLEGPAVTVDTGCSASLVALHLAVQSLSRGECSLALAGGVTVMSNPGTFIEFSRQRGLAADGRCKAFSDSADGTGWAEGVGMLLVERLSDARRNGHEVLAVVRGSAINQDGASNGLTAPNGRSQQRVIRQALASASLTPAEVDVVEAHGTGTKLGDPIEAQALLATYGQDRPAERPLLLGALKSNIGHTQAAAGVAGVIKMVLAMRHGVAPQTLHVEQPTAEVDWSAGAVELLTEARPWPDADRPRRAGVSAFGVGGTNAHVIIEEAQSAPAQERTAPEPPAALPWLVSGATPDALRAQAERLLTHLADQPETHAADVAYSLSLTRSSLDHRAAVVAADRDELLAGLAALAEGRSAPGLVRGAPHSGDRVAFVFPGQGSQWPGMAQELAAAFPAFAARLRACEDALAEFVDWSLTDVLSEAPDAPPLDRVDVVQPVLWAVMVSLAELWRSYGVEPDAVLGHSQGEIAAACVAGALTLQDAARVVALRSKAIVAIAGQGGMLSVPLSREGLRPHLARWQDRLSVAAVNGPETVVLSGDVQAVDGLCAELQGEQIRAKKIQVDYASHSAHVEAIEAELFDALAPITPRAGSVPFFSTVTGDWYDTTGLDAGYWYRNLRQTVELHRATEALVEQGFGVFVESSPHPVLAVGMQDTVEAAGGDAVILGSLRRDDGGPDRFLRSLAEAHTHAVGVDWHALFTDGAGHRVELPTYAFQRKRYWLQDTAPEHRADAPAVDPVDAAFWEAVEREDLDALAGVLDLGTPDDTASLDTVLPALPVLSSWRRKRLDRSTVDAWRYRVEWRRIDDAPAPATLTGTWLVVIPEGYEADERVTASARALAERGADVVEVRVDEAGEDRTALAERLSDTGADTGPVAGVLSFLALAEQGFPQHPEVPTGLALTLHLVQALGDAGIDAPLWSVTSGAVSTGDDEAPSHPVQAHIWGMGRVAALEHSERWGGLVDLPEAPDEQAARRLGAVLADTRGEDQVAIRPSGLYGRRLARAAATEAGERQRWTPRGTVLITGGTGALGAHVARRLAAQGAEHLVLVSRSGEAAPGADDLRTKLGVPVTVAACDIADRDQVAALLARLEADGTPVRTVVHTAGVARLTPLAQTDLAELADVLSGKAAGARHLLELLDLDNLDTFVLFSSIAAAWGVADHGAYAAANAYLDAMALQYRAQGLPVSSVGWGPWDGDGMVSLNKLLARRGIPVIAPDLAITALQQALDERDTYVAVADVDWDRFTQVFTSARPSPLLADFTETAADDRETASATAHGTDSELVRRLNALPEDERAQALQDLVLTEAAAVLGHTTTDALGAVRPYRDLGFDSLTSVEFRNRLRDATGLALPATLVFDHPTPQATTEYLLQRIAGDKPIVDRASSSAVAAVEADDPIAIVAMGCRYPGGVASPEELWELMAAEGDAISGFPTDRGWDLDALYDPDPDRAGHTYVREGGFLHDAAEFDAEFFGISPREASAMDPQQRLLLETSWEAFERAGIDPAALRGSATGVFVGSNYQDYGLGSGSGSQQSSGVSEGHELIGSAPSVLSGRLSYTFGLEGPAVTVDTACSSSLVALHLAVQSLRQGESDLALAGGVAYMANPRAFVGFSRQRGLARDARCKAFADRADGMTLAEGVGLVLLERLSDARRLGHPVLAVVRGSAINQDGASNGLTAPNGPAQQRVIRQALANARLTPSEVDVVEAHGTGTALGDPIEAQALLATYGQERVEGQPLWLGSVKSNIGHTQAAAGVASVIKTVLAMGRGTVPATLHVDRPSSHVDWSAGAVELLTEARAWPENGHPRRAGVSSFGISGTNAHVILEQAPAESGEPPQQDLPVDGESAASVVPWVVSARSVRALQAQAGQLAAWAASPAGEQASPADVAQALATTRTFFEYRTVVVGGDRAELVETLRSLSTDPSAAGTVRRADTDGGGRLGLVFSGQGSQRAGMGRELYVAFPVFAEAFDEVCGVLDEVMGALPPSEGWAGSLREVMFDVAGGSLDETGFTQPALFAFEVALYRLLESWGVAGEVVAGHSVGEIAAVHVAGVLSLADACALVAARGRLMQGLPSGGAMVAVEASEEEVTALLAGREGEVGIGAVNGPRSVVVSGGVAVVEEVAAHFAGLGRRARRLKVSHAFHSPLMDPMLEDFGRVVAGLSFAVPELTVVSGLTGAVVSADELCSVGYWVRHAREAVRFADAVGAMAGVGVGRFVEVGPGGVLSALVRECLAEGGAGSVVAAVRGNRAEPVALVSAVGELFADGYPVDWTAYFAGWPAARVELPTYAFQRSRYWLEELAGTAVRRTEAGGQDEVDAAFWEAVEQGDLSSLGTGEGVDGEARLADVLPVLSSWRRQAGQVSLADSWRYRVTWNALPEPGVASFGGTWLLLAPAGSEAAGSLVRSLAEAMAEHGAEVVTVDLGHPDSDRARDALAEQITGRLDGLAPGQVGGVVSLLALAEGTDPHHPTVSRGLALTLSAVQALGDAGVTAPLWCLTRGAVSAGATSGPDEPVQAQVWGLGRVAALEHPDRWGGLLDLPEQVDSRTVRRLVRALAAGHRPGGEDQIALRTAGVLARRLVQDAAPAGDSVAWTPSGTVLVTGGTGAVGGHVARWLAARGAERVVLVSRRGPEAPGAQALHDELTEAGVRVRLVACDLRDQEAVTALVAGLADEGDLTAVVHAAGVLDDGVLASLSVERCAEVLAAKAQAAHHLDLATREVDLDAFVLFSSASGVLGSAGQANYAAANAYLDALAELRHALGLPAVSLAWGRWADGGMADQDVVAGRLDRDGWPAMAAEAALNAMARAVTAGRPAVMVADVDWQRFAPAFTAARPSPLLSALPQAQLPTAAAHGPAEGEQSSWASRLAELPAAEQQTALLDLIRGQVASVLGHASVQTIDPARAFKEIGFDSLTAVELRNRLNAATGLALPTTLVFDYPTPEALAEYVGSEVLGTSSSAAVGGPLVVAAVDEPVAIIGMSCRFPGGVQSPEELWDLVAGGRDTISSFPADRGWDIDTLFDPDGERSGTSSTRYGAFLDGAADFDPAFFDIGPREATAMDPQQRLLLETAWEAFERAGIDPAALRGSATGVFTGTNGQDYATLASGAAAEFEGYLGIGNAGSVISGRLAYTFGLEGPAMTVDTACSASLVALHLAAQALRQGECSLALAGGATVMATPGAFVEFSRQRGLAPDGRCKAFSASADGTGWGEGAGMLLLERLSDAERNGHPILAVVRGSAVNQDGASNGLTAPNGPAQQRVIRQALANARLSASEVDVVEAHGTGTKLGDPIEAQALLATYGQDRAEDRPLWLGSVKSNLGHTQAAAGVAGIIKSVMAMRHGTLPATLHVDEPTPEVNWSTGAVELLTESRPWPATDHVRRAAVSSFGVSGTNAHVILEQAADPVAEAESGAALVPDAVPVPWVVSARSADAVREQARRLHTHLMTGREWRPADVGYSLATARSRFEHRAVVLGEDQGELLEALEALAEGRGDSRVRVGAGLAGGRTGFVFAGQGSQRLGMGGRLREMFPVFGEAWDEVVAELDGRLGRPLGEVVFAEEGSEQASLVDRTEFTQPALFAFEVALFRLLESWGVVPDVVAGHSIGELAAAYVAGVLSLSDACALVVARGRLMQALPAGGAMVAVQVTEAEARRLVEGEPSGAVDIAAVNGPESVVIAGDEDVVLRVQEIVRGRGRKTKRLTVSHAFHSPRMEPMLDEFRRVAETVTYHEPRIAVVSAVSGEVAGAELRSAEYWTRHVREAVRFYDAVRCLRSEGVSTFVEVGPDGALSALGQDCLVGEEARGTEFVSTVRAGRDEAESVVAAVGAAHVRGVPVDWAAYYAPYGPRRADLPTYAFEHQRYWLDTSARPGRDATGLGLGSAEHPLLGAAVALADGDGVLLTGRLSLATHPWLADHQVQGAVLFPGTAFVELALRAGEQVGADCVEELTLEVPLVLPERGGVQVQVVVGAADEQGGRPVTVHSRPETGVDEPWTRHATGVLASGAATVPAETGELAVWPPQGATAVDIDGLYDRLVDGGFGYGPVFQGLRAVWRRGSEVFAEVALDDTHRDGAGEFGLHPALLDAALHAIGFGEFVSDGGAGVLPFSWNGVHLYASGADALRVRVSGVGVGANEVALVVADGSGRPVAAVESLVLRPVSADTIAAGAGARQSLFRVGWRQVAVPDQAGAGEWVALDRGAGWAQGEGCEVLPDLAALGSAVSAGRSVPRLVVAHFAADREVPVTAGVRGVTAEGLELIQSWLADERFADSRLVIMTRQAVAVDAGEGVFDLGAAALWGLVRTAQSEQPGRVVLVDVDDLDAVSRVVGIGDEPQLAVRDGRVFVPRLMRAEAIDGVPVWDPEGTLLITGASGALGGVVARHVVREWGVRHLVLASRRGAEAPGMTELVAELGELGASAAPVACDVADRDALAAVLAGIPAVHRLAGVVHAAGVLDDGVVGSLTPERLETVLAPKADAAWHLHELAAELDLSVFVLFSSAASVFGGAGQGNYAAANAFLDALAARRRADGLVATSLSWGLWDQAGGMTGQLGEADVARMSRSGVLPISVGEALPLLDAGVTGGDAWLAPVRLDLAALRQQAIATGGVPALLRDLVRVPNRRKAETGGSSTGGSRSTLLDKLAGLTDAEREQELLDFVCEHTAAVLGHSGAGMVDPGRGFLEAGVDSLAAVELRNRIGGVLGIRLSATLVFDYPSPVLLAGHIGEQLALDEPAPEPMMAAELERLEAAVTAGRFDDASRDEVAVRLRKLLTYFDTVADTARGETDDGDVASASVDELFALLDEELDDR", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more PKS_Beta-ketoAc_synthase_dom, PP-bd_ACP, Acyl_transferase_dom, Acyl_transferase_dom, Acyl_transferase_dom, Acyl_transferase_dom, Acyl_transferase_dom, PP-bd_ACP, PKS_Beta-ketoAc_synthase_dom, PKS_Beta-ketoAc_synthase_dom, PKS_DH, PP-bd_ACP, PKS_DE, PKS_DE, PKS_KR, PKS_KR, PKS_KR, PKS_KR, PKS_Beta-ketoAc_synthase_dom, PKS_assoc, PKS_assoc, PKS_assoc, PKS_assoc, PKS_assoc, PKS_mFAS_DH, Ketoacyl_synth_N, Ketoacyl_synth_N, Ketoacyl_synth_N, Ketoacyl_synth_N, Ketoacyl_synth_N, PKS_DH_C, PP-bd_ACP, PP-bd_ACP, PP-bd_ACP, PP-bd_ACP, PP-bd_ACP, Ketoacyl_synth_C, Ketoacyl_synth_C, Ketoacyl_synth_C, Ketoacyl_synth_C, Ketoacyl_synth_C, Acyl_transferase_dom, Acyl_transferase_dom, Acyl_transferase_dom, Acyl_transferase_dom, Acyl_transferase_dom, PKS_Beta-ketoAc_synthase_dom, PKS_DH_N, PKS_PP-bd, PKS_PP-bd, PKS_PP-bd, PKS_PP-bd, PKS_PP-bd, PP-bd_ACP, PP-bd_ACP, PKS_Beta-ketoAc_synthase_dom, PKS_Beta-ketoAc_synthase_dom, PKS_Beta-ketoAc_synthase_dom, PKS_Beta-ketoAc_synthase_dom, PKS_Beta-ketoAc_synthase_dom that are essential for its biological function; 2. The protein should belong to PKS_NRPS_Biosynth_Enz that shares evolutionary origin and functional similarity; 3. The protein should be classified within NAD(P)-bd_dom_sf, Malonyl_transacylase_ACP-bd, NAD(P)-bd_dom_sf, NAD(P)-bd_dom_sf, Thiolase-like, Acyl_Trfase/lysoPLipase, ACP-like_sf, ACP-like_sf, ACP-like_sf, ACP-like_sf, ACP-like_sf, Acyl_Trfase/lysoPLipase, NAD(P)-bd_dom_sf, Malonyl_transacylase_ACP-bd, Thiolase-like, Thiolase-like, Acyl_Trfase/lysoPLipase, ACP-like_sf, ACP-like_sf, ACP-like_sf, NAD(P)-bd_dom_sf, NAD(P)-bd_dom_sf, Malonyl_transacylase_ACP-bd, Thiolase-like, Acyl_Trfase/lysoPLipase, Thiolase-like, Thiolase-like, Thiolase-like, Thiolase-like, Thiolase-like, Ac_transferase_dom_sf, Ac_transferase_dom_sf, Ac_transferase_dom_sf, Ac_transferase_dom_sf, Ac_transferase_dom_sf, NAD(P)-bd_dom_sf, Malonyl_transacylase_ACP-bd, ACP-like_sf, Thiolase-like, Acyl_Trfase/lysoPLipase, ACP-like_sf, PKS_dehydratase_sf, Malonyl_transacylase_ACP-bd, NAD(P)-bd_dom_sf sharing conserved structural features; 4. The protein must have Ketoacyl_synth_AS, Ketoacyl_synth_AS, Ketoacyl_synth_AS, Ketoacyl_synth_AS that is conserved among related catalytic enzymes; 5. The protein should contain Ppantetheine_attach_site, Ppantetheine_attach_site, Ppantetheine_attach_site, Ppantetheine_attach_site that allow regulation through chemical modifications. The designed protein sequence is ", "reference": "MNHIPVNRGVCLMGRSQNSEFETASDEPIAVIGLSCRLPKASGPQELWQLLDDGASAVTRVPADRETPPSTEEESADGEAAGARWGGFLDRVDTFDAGFFGISPREAAAMDPQQRLVLELSWEALEGAGLVPATLRDTGLGVFVGAARDDYATLYRRREGRAVDHHAMTGLHRSLIANRISYALGAHGPSMVVDTGQSSSLVAVHLACESLRRGESDIALAGGVNLNIAAESARETAAFGGLSPDGQCFTFDARANGFVRGEGGGLVVLKTLRRALADGDLVHGVILASAVNNDGPSDTLTTPSRRAQESLLTRVYRRAGVTPTEVGYVELHGTGTKVGDPIEAAALGAVLGTGRDTPLPVGSIKTNIGHLEGAAGIAGLIKALLQLRRRRLVPSLNFSTPNPDIPLDALNLRVQQESAPWATPSGGGRTLVAGVSSFGMGGTNCHVVVSAAPVPEDGETTSEAGATGPDSGPALLPWVVSARSPQALRDQAGRLAAWADSPAGREASPVDIGWSLATSRTHFEYRAVVSGSDRDELVASLRALASGSPVTAAGAVDGGGRLGLVFSGQGSQRAGMGRELYVAFPVFAEAFDEVCGVLDEVMGALPPSEGWAGSLREVMFEVSSDLLDETGFTQPALFAFEVALYRLLESWGVAGEVVAGHSVGEIAAVHVAGVLSLADACALVAARGRLMQGLPSGGAMVAVEASEEEVTALLAGREGEVGIGAVNGPRSVVVSGGVAVVEEVAAHFAGLGRRARRLKVSHAFHSPLMDPMLEDFGRVVAGLSFAVPELTVVSGLTGAVVSADELCSVGYWVRHAREAVRFADAVGAMAGVGVGRFVEVGPGGVLSALVRECLAEGGAGSVVAAVRGNRAEPVALLSAVGELFADGYPVDWTAYFAGWPAARVELPTYAFQRSRHWLENVPELAVSTTPPAVPREPVTPDSDHPDPVETVRQLTAHVLGLTAAADVEMTRSFKDLGFDSLMSVELRDRLCAATGLSLATTLLYDHPSPAETAEFVRARLTGDEAAAVEVVAARAVEDEPIAVVAMSCRFPGGVRTPEDLWELVRDRVDAVSVFPSDRGWNADAGLFPPAGGFLYDGHHFDAEFFGISPREALAMDPQQRLLLETSWEAFERAGIDPVSLRGSRTGVFVGATAQDYTPKLGEPADGLEGHLLTGGTVSVASGRISYFLGLEGPAVTVDTACSSSLVSLHLACRSLRQGETTLALAGGVTLMATPGMFAEFSRQGGLAADGRCKAFAEAADGTGWAEGVGLVLLERLSDARRNGHPVLAVVRGSAVNQDGASNGLTAPNGPSQQRVIRQALADARLAPADVDLMEAHGTGTRLGDPIEAQALLATYGQGRSGDRPLWLGSVKSNIGHTQAAAGVAGLIKTVMAMRHGTMPATLHVDRPSSHVDWSTGAVELLTEAQPWPDTERPRRAAVSSFGVSGTNAHVILEQATEPAALDAAPDAIVSDAVVAWPLSARDVGALREQAVRLVARVTGDPYVRPADVGHSLAATRSSFEHRAVVVGRERAELLAGLEALASGETAANLATGRASADGAGKVVFVFPGQGSQWPGMGLELAAHSPVFAAVLEDCGRALAAYVDWDGHTLHEVLAQEDGAPSLERVDVVQPALWAVMVALAALWRSHGVQPDAVVGHSQGEIAAACVAGALTLDEAAQVVSLRSRAITALAGAGQMVSVPLPEADTAEWIRPWADAGQIGIAAVNGPGSTVVSGDSAAMDELMEALAAQDVRARRIPVDYASHSPQVARIRDELLHALDGLTPRPATVPVFSTVTGEWLDDTTPMDAEYWYRNLRQTVRFEEAVRALADSGCGVFIEASPHPVLTIGVQETLDVLDRTGVVTGSLRRQKGGPDRFLSSLAQVHTHGGRVDWDTVFAGTGATRTDLPTYPFQRHRYWLERPQAPAVAPAASPAASVSETDSTRYRVVFKPLPEPTAARLSGTWLLVVPDTDEPDARVDAVTGALVTAGATVERIVVEAGADRADLAELLAALATDVGGVRGVVSLLALSEDADAMRPSVPSGLASTLTLVQALGDADVSAPLWCLTRGAVSVGASDRLDSPVQALVWGLGRAAAVEHPERWGGLLDLPATLTGRVLDRLVGVLAADGDEDQVAVRAAGVFGRRLVRGNSAPTRIDHSWQAGGTVLVTGGTGALGARVARWLVDSGAEHVVVASRQGADAPGADRLRDELTGLGARVTPVACDVSDRSAVAELVDRCAEQGDPIRAVVHTAGVGVTKPLADTTPDDLAVSFDAKVAGATHLADALGADLDAFVLFSSAAGVWGSGGQGAYGAANAYLDALAAQRAADGLAATAVAWGPWDGGGMSADAAVIDMDALRRSGLTAMDPDRAIDALDRALTDGETALTVVDVDWTRFAEVFTTARRSPLLADLPEAARLVGPAPTARENSSPVAARLAKASSAAEGRRVLLDLVRGRVADVLGHATPDTIRADRPFKDLGFNSLMTLELRSGLNEATGLRLSATTLFDHPTPSALAEHLAGELLGTPRAEAGPEMPATAPEVTEDPIAIVAMSCRFPGGVGSPEALWRLVADRRDVISGMPADRGWDIDGIYDPVPGVPGRTYTRQGGFLDGVGEFDAEFFGISPREATAMDPQQRLLLETSWEAFERAGIDPTQLRGDSVGVFVGCTGQDYVPRLHETSDELGGYALTGAAGSVASGRVAYTFGLEGPAVTVDTGCSASLVALHLAVQSLSRGECSLALAGGVTVMSNPGTFIEFSRQRGLAADGRCKAFSDSADGTGWAEGVGMLLVERLSDARRNGHEVLAVVRGSAINQDGASNGLTAPNGRSQQRVIRQALASASLTPAEVDVVEAHGTGTKLGDPIEAQALLATYGQDRPAERPLLLGALKSNIGHTQAAAGVAGVIKMVLAMRHGVAPQTLHVEQPTAEVDWSAGAVELLTEARPWPDADRPRRAGVSAFGVGGTNAHVIIEEAQSAPAQERTAPEPPAALPWLVSGATPDALRAQAERLLTHLADQPETHAADVAYSLSLTRSSLDHRAAVVAADRDELLAGLAALAEGRSAPGLVRGAPHSGDRVAFVFPGQGSQWPGMAQELAAAFPAFAARLRACEDALAEFVDWSLTDVLSEAPDAPPLDRVDVVQPVLWAVMVSLAELWRSYGVEPDAVLGHSQGEIAAACVAGALTLQDAARVVALRSKAIVAIAGQGGMLSVPLSREGLRPHLARWQDRLSVAAVNGPETVVLSGDVQAVDGLCAELQGEQIRAKKIQVDYASHSAHVEAIEAELFDALAPITPRAGSVPFFSTVTGDWYDTTGLDAGYWYRNLRQTVELHRATEALVEQGFGVFVESSPHPVLAVGMQDTVEAAGGDAVILGSLRRDDGGPDRFLRSLAEAHTHAVGVDWHALFTDGAGHRVELPTYAFQRKRYWLQDTAPEHRADAPAVDPVDAAFWEAVEREDLDALAGVLDLGTPDDTASLDTVLPALPVLSSWRRKRLDRSTVDAWRYRVEWRRIDDAPAPATLTGTWLVVIPEGYEADERVTASARALAERGADVVEVRVDEAGEDRTALAERLSDTGADTGPVAGVLSFLALAEQGFPQHPEVPTGLALTLHLVQALGDAGIDAPLWSVTSGAVSTGDDEAPSHPVQAHIWGMGRVAALEHSERWGGLVDLPEAPDEQAARRLGAVLADTRGEDQVAIRPSGLYGRRLARAAATEAGERQRWTPRGTVLITGGTGALGAHVARRLAAQGAEHLVLVSRSGEAAPGADDLRTKLGVPVTVAACDIADRDQVAALLARLEADGTPVRTVVHTAGVARLTPLAQTDLAELADVLSGKAAGARHLLELLDLDNLDTFVLFSSIAAAWGVADHGAYAAANAYLDAMALQYRAQGLPVSSVGWGPWDGDGMVSLNKLLARRGIPVIAPDLAITALQQALDERDTYVAVADVDWDRFTQVFTSARPSPLLADFTETAADDRETASATAHGTDSELVRRLNALPEDERAQALQDLVLTEAAAVLGHTTTDALGAVRPYRDLGFDSLTSVEFRNRLRDATGLALPATLVFDHPTPQATTEYLLQRIAGDKPIVDRASSSAVAAVEADDPIAIVAMGCRYPGGVASPEELWELMAAEGDAISGFPTDRGWDLDALYDPDPDRAGHTYVREGGFLHDAAEFDAEFFGISPREASAMDPQQRLLLETSWEAFERAGIDPAALRGSATGVFVGSNYQDYGLGSGSGSQQSSGVSEGHELIGSAPSVLSGRLSYTFGLEGPAVTVDTACSSSLVALHLAVQSLRQGESDLALAGGVAYMANPRAFVGFSRQRGLARDARCKAFADRADGMTLAEGVGLVLLERLSDARRLGHPVLAVVRGSAINQDGASNGLTAPNGPAQQRVIRQALANARLTPSEVDVVEAHGTGTALGDPIEAQALLATYGQERVEGQPLWLGSVKSNIGHTQAAAGVASVIKTVLAMGRGTVPATLHVDRPSSHVDWSAGAVELLTEARAWPENGHPRRAGVSSFGISGTNAHVILEQAPAESGEPPQQDLPVDGESAASVVPWVVSARSVRALQAQAGQLAAWAASPAGEQASPADVAQALATTRTFFEYRTVVVGGDRAELVETLRSLSTDPSAAGTVRRADTDGGGRLGLVFSGQGSQRAGMGRELYVAFPVFAEAFDEVCGVLDEVMGALPPSEGWAGSLREVMFDVAGGSLDETGFTQPALFAFEVALYRLLESWGVAGEVVAGHSVGEIAAVHVAGVLSLADACALVAARGRLMQGLPSGGAMVAVEASEEEVTALLAGREGEVGIGAVNGPRSVVVSGGVAVVEEVAAHFAGLGRRARRLKVSHAFHSPLMDPMLEDFGRVVAGLSFAVPELTVVSGLTGAVVSADELCSVGYWVRHAREAVRFADAVGAMAGVGVGRFVEVGPGGVLSALVRECLAEGGAGSVVAAVRGNRAEPVALVSAVGELFADGYPVDWTAYFAGWPAARVELPTYAFQRSRYWLEELAGTAVRRTEAGGQDEVDAAFWEAVEQGDLSSLGTGEGVDGEARLADVLPVLSSWRRQAGQVSLADSWRYRVTWNALPEPGVASFGGTWLLLAPAGSEAAGSLVRSLAEAMAEHGAEVVTVDLGHPDSDRARDALAEQITGRLDGLAPGQVGGVVSLLALAEGTDPHHPTVSRGLALTLSAVQALGDAGVTAPLWCLTRGAVSAGATSGPDEPVQAQVWGLGRVAALEHPDRWGGLLDLPEQVDSRTVRRLVRALAAGHRPGGEDQIALRTAGVLARRLVQDAAPAGDSVAWTPSGTVLVTGGTGAVGGHVARWLAARGAERVVLVSRRGPEAPGAQALHDELTEAGVRVRLVACDLRDQEAVTALVAGLADEGDLTAVVHAAGVLDDGVLASLSVERCAEVLAAKAQAAHHLDLATREVDLDAFVLFSSASGVLGSAGQANYAAANAYLDALAELRHALGLPAVSLAWGRWADGGMADQDVVAGRLDRDGWPAMAAEAALNAMARAVTAGRPAVMVADVDWQRFAPAFTAARPSPLLSALPQAQLPTAAAHGPAEGEQSSWASRLAELPAAEQQTALLDLIRGQVASVLGHASVQTIDPARAFKEIGFDSLTAVELRNRLNAATGLALPTTLVFDYPTPEALAEYVGSEVLGTSSSAAVGGPLVVAAVDEPVAIIGMSCRFPGGVQSPEELWDLVAGGRDTISSFPADRGWDIDTLFDPDGERSGTSSTRYGAFLDGAADFDPAFFDIGPREATAMDPQQRLLLETAWEAFERAGIDPAALRGSATGVFTGTNGQDYATLASGAAAEFEGYLGIGNAGSVISGRLAYTFGLEGPAMTVDTACSASLVALHLAAQALRQGECSLALAGGATVMATPGAFVEFSRQRGLAPDGRCKAFSASADGTGWGEGAGMLLLERLSDAERNGHPILAVVRGSAVNQDGASNGLTAPNGPAQQRVIRQALANARLSASEVDVVEAHGTGTKLGDPIEAQALLATYGQDRAEDRPLWLGSVKSNLGHTQAAAGVAGIIKSVMAMRHGTLPATLHVDEPTPEVNWSTGAVELLTESRPWPATDHVRRAAVSSFGVSGTNAHVILEQAADPVAEAESGAALVPDAVPVPWVVSARSADAVREQARRLHTHLMTGREWRPADVGYSLATARSRFEHRAVVLGEDQGELLEALEALAEGRGDSRVRVGAGLAGGRTGFVFAGQGSQRLGMGGRLREMFPVFGEAWDEVVAELDGRLGRPLGEVVFAEEGSEQASLVDRTEFTQPALFAFEVALFRLLESWGVVPDVVAGHSIGELAAAYVAGVLSLSDACALVVARGRLMQALPAGGAMVAVQVTEAEARRLVEGEPSGAVDIAAVNGPESVVIAGDEDVVLRVQEIVRGRGRKTKRLTVSHAFHSPRMEPMLDEFRRVAETVTYHEPRIAVVSAVSGEVAGAELRSAEYWTRHVREAVRFYDAVRCLRSEGVSTFVEVGPDGALSALGQDCLVGEEARGTEFVSTVRAGRDEAESVVAAVGAAHVRGVPVDWAAYYAPYGPRRADLPTYAFEHQRYWLDTSARPGRDATGLGLGSAEHPLLGAAVALADGDGVLLTGRLSLATHPWLADHQVQGAVLFPGTAFVELALRAGEQVGADCVEELTLEVPLVLPERGGVQVQVVVGAADEQGGRPVTVHSRPETGVDEPWTRHATGVLASGAATVPAETGELAVWPPQGATAVDIDGLYDRLVDGGFGYGPVFQGLRAVWRRGSEVFAEVALDDTHRDGAGEFGLHPALLDAALHAIGFGEFVSDGGAGVLPFSWNGVHLYASGADALRVRVSGVGVGANEVALVVADGSGRPVAAVESLVLRPVSADTIAAGAGARQSLFRVGWRQVAVPDQAGAGEWVALDRGAGWAQGEGCEVLPDLAALGSAVSAGRSVPRLVVAHFAADREVPVTAGVRGVTAEGLELIQSWLADERFADSRLVIMTRQAVAVDAGEGVFDLGAAALWGLVRTAQSEQPGRVVLVDVDDLDAVSRVVGIGDEPQLAVRDGRVFVPRLMRAEAIDGVPVWDPEGTLLITGASGALGGVVARHVVREWGVRHLVLASRRGAEAPGMTELVAELGELGASAAPVACDVADRDALAAVLAGIPAVHRLAGVVHAAGVLDDGVVGSLTPERLETVLAPKADAAWHLHELAAELDLSVFVLFSSAASVFGGAGQGNYAAANAFLDALAARRRADGLVATSLSWGLWDQAGGMTGQLGEADVARMSRSGVLPISVGEALPLLDAGVTGGDAWLAPVRLDLAALRQQAIATGGVPALLRDLVRVPNRRKAETGGSSTGGSRSTLLDKLAGLTDAEREQELLDFVCEHTAAVLGHSGAGMVDPGRGFLEAGVDSLAAVELRNRIGGVLGIRLSATLVFDYPSPVLLAGHIGEQLALDEPAPEPMMAAELERLEAAVTAGRFDDASRDEVAVRLRKLLTYFDTVADTARGETDDGDVASASVDELFALLDEELDDR" }, { "InterPro": [ { "InterPro-ID": "IPR036291", "InterPro-Name": "NAD(P)-bd_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 48, "End": 321 }, { "InterPro-ID": "IPR002347", "InterPro-Name": "SDR_fam", "InterPro-Type": "FAMILY", "Beg": 52, "End": 176 } ], "response#1": "MAGYLPEPLRMMVTNPAISDFTSDGPLPYALRQKFTGWPPPPAAADISLASQTVLVTGATSGVGLEAARQLAQLGPRLLILGARNLSKADGVKRQLEQDTPHVAVQVAKLDLEDLSSVDRFVDGLHASAIHLDLALLNAGFFANDDRMTPDGYSSLFQVNFLSTAYLAFRLLPLLQTTTTAPEASPQGPRLVLVTSEAHAWTTFPVPPEPAENSLPILSSFRQKESLGSADDQYYRAKLLLALIGKELSRRLTTMQMATSVVITTPGFCASNFFPDSVMTRLIQLISARSIQQGGALHVFAATAQGPQMHGAYLRDGKPTGLSKFAEGPQGQILQQRLWVEMEQFLAGRGYLLSSILKPSSPLQIDGPV", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to SDR_fam that shares evolutionary origin and functional similarity; 2. The protein should be classified within NAD(P)-bd_dom_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MAGYLPEPLRMMVTNPAISDFTSDGPLPYALRQKFTGWPPPPAAADISLASQTVLVTGATSGVGLEAARQLAQLGPRLLILGARNLSKADGVKRQLEQDTPHVAVQVAKLDLEDLSSVDRFVDGLHASAIHLDLALLNAGFFANDDRMTPDGYSSLFQVNFLSTAYLAFRLLPLLQTTTTAPEASPQGPRLVLVTSEAHAWTTFPVPPEPAENSLPILSSFRQKESLGSADDQYYRAKLLLALIGKELSRRLTTMQMATSVVITTPGFCASNFFPDSVMTRLIQLISARSIQQGGALHVFAATAQGPQMHGAYLRDGKPTGLSKFAEGPQGQILQQRLWVEMEQFLAGRGYLLSSILKPSSPLQIDGPV" }, { "InterPro": [ { "InterPro-ID": "IPR013087", "InterPro-Name": "Znf_C2H2_type", "InterPro-Type": "DOMAIN", "Beg": 18, "End": 41 }, { "InterPro-ID": "IPR036236", "InterPro-Name": "Znf_C2H2_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 13, "End": 43 }, { "InterPro-ID": "IPR013087", "InterPro-Name": "Znf_C2H2_type", "InterPro-Type": "DOMAIN", "Beg": 20, "End": 41 } ], "response#1": "MAVLKAIKIEDRDGEILFRCPRCGMVFRSAKAYTRHVNKAHGHLFRK", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Znf_C2H2_type, Znf_C2H2_type that are essential for its biological function; 2. The protein should be classified within Znf_C2H2_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MAVLKAIKIEDRDGEILFRCPRCGMVFRSAKAYTRHVNKAHGHLFRK" }, { "InterPro": [ { "InterPro-ID": "IPR001266", "InterPro-Name": "Ribosomal_eS19", "InterPro-Type": "FAMILY", "Beg": 3, "End": 139 }, { "InterPro-ID": "IPR036388", "InterPro-Name": "WH-like_DNA-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1, "End": 150 }, { "InterPro-ID": "IPR036390", "InterPro-Name": "WH_DNA-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 3, "End": 150 }, { "InterPro-ID": "IPR018277", "InterPro-Name": "Ribosomal_eS19_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 87, "End": 106 }, { "InterPro-ID": "IPR001266", "InterPro-Name": "Ribosomal_eS19", "InterPro-Type": "FAMILY", "Beg": 5, "End": 140 }, { "InterPro-ID": "IPR027548", "InterPro-Name": "Ribosomal_eS19_archaeal", "InterPro-Type": "FAMILY", "Beg": 1, "End": 148 } ], "response#1": "MATVYDVPGDLLVERVAKALKEVPEIKPPEWAPFVKTGRHKERLPEQEDWWYYRVASVFRKVYIDGPVGIERLRTWYGGRKNRGHAPEHFYKAGGSIIRKALQQLEAAGFVQKVPGEGRIVTPKGQSFLDKIATELKKELEEQIPELKKY", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Ribosomal_eS19, Ribosomal_eS19, Ribosomal_eS19_archaeal that shares evolutionary origin and functional similarity; 2. The protein should be classified within WH-like_DNA-bd_sf, WH_DNA-bd_sf sharing conserved structural features; 3. The protein should contain Ribosomal_eS19_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MATVYDVPGDLLVERVAKALKEVPEIKPPEWAPFVKTGRHKERLPEQEDWWYYRVASVFRKVYIDGPVGIERLRTWYGGRKNRGHAPEHFYKAGGSIIRKALQQLEAAGFVQKVPGEGRIVTPKGQSFLDKIATELKKELEEQIPELKKY" }, { "InterPro": [ { "InterPro-ID": "IPR002140", "InterPro-Name": "Sdo1/SBDS", "InterPro-Type": "FAMILY", "Beg": 3, "End": 231 }, { "InterPro-ID": "IPR018023", "InterPro-Name": "Ribosome_mat_SBDS_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 37, "End": 56 }, { "InterPro-ID": "IPR037188", "InterPro-Name": "Sdo1/SBDS_central_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 88, "End": 162 }, { "InterPro-ID": "IPR018978", "InterPro-Name": "SDO1/SBDS_central", "InterPro-Type": "DOMAIN", "Beg": 103, "End": 162 }, { "InterPro-ID": "IPR046928", "InterPro-Name": "SDO1/SBDS_C", "InterPro-Type": "DOMAIN", "Beg": 167, "End": 232 }, { "InterPro-ID": "IPR035647", "InterPro-Name": "EFG_III/V", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 157, "End": 228 }, { "InterPro-ID": "IPR039100", "InterPro-Name": "Sdo1/SBDS-like", "InterPro-Type": "FAMILY", "Beg": 5, "End": 232 }, { "InterPro-ID": "IPR036786", "InterPro-Name": "Ribosome_mat_SBDS_N_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 8, "End": 87 }, { "InterPro-ID": "IPR036786", "InterPro-Name": "Ribosome_mat_SBDS_N_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 4, "End": 87 }, { "InterPro-ID": "IPR037188", "InterPro-Name": "Sdo1/SBDS_central_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 82, "End": 155 }, { "InterPro-ID": "IPR019783", "InterPro-Name": "SDO1/SBDS_N", "InterPro-Type": "DOMAIN", "Beg": 8, "End": 94 } ], "response#1": "MPISVDKAVIARLKTHGETFEILVDPYLARDFKEGKDVPIEEILATPYVFKDAHKGDKASEHEMEKIFGTSDPYEVAKIILRKGEVQLTAEQRRQMLEDKKRYIATVIHRHAVDPRTGYPHPVDRILRAMEEAGVHIDIFKDAEAQVPQVIKAIRPILPLKLEVKVIAVKIPGDYVGRAYGEVRKFGNIKREEWGSDGSWMFVIEIPGGVEEEFYEKLNALTKGEAITKLLERKGL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more SDO1/SBDS_central, SDO1/SBDS_C, SDO1/SBDS_N that are essential for its biological function; 2. The protein should belong to Sdo1/SBDS, Sdo1/SBDS-like that shares evolutionary origin and functional similarity; 3. The protein should be classified within Sdo1/SBDS_central_sf, EFG_III/V, Ribosome_mat_SBDS_N_sf, Ribosome_mat_SBDS_N_sf, Sdo1/SBDS_central_sf sharing conserved structural features; 4. The protein should contain Ribosome_mat_SBDS_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MPISVDKAVIARLKTHGETFEILVDPYLARDFKEGKDVPIEEILATPYVFKDAHKGDKASEHEMEKIFGTSDPYEVAKIILRKGEVQLTAEQRRQMLEDKKRYIATVIHRHAVDPRTGYPHPVDRILRAMEEAGVHIDIFKDAEAQVPQVIKAIRPILPLKLEVKVIAVKIPGDYVGRAYGEVRKFGNIKREEWGSDGSWMFVIEIPGGVEEEFYEKLNALTKGEAITKLLERKGL" }, { "InterPro": [ { "InterPro-ID": "IPR015655", "InterPro-Name": "PP2C", "InterPro-Type": "FAMILY", "Beg": 112, "End": 467 }, { "InterPro-ID": "IPR001932", "InterPro-Name": "PPM-type_phosphatase-like_dom", "InterPro-Type": "DOMAIN", "Beg": 138, "End": 470 }, { "InterPro-ID": "IPR036457", "InterPro-Name": "PPM-type-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 133, "End": 488 }, { "InterPro-ID": "IPR001932", "InterPro-Name": "PPM-type_phosphatase-like_dom", "InterPro-Type": "DOMAIN", "Beg": 139, "End": 470 }, { "InterPro-ID": "IPR001932", "InterPro-Name": "PPM-type_phosphatase-like_dom", "InterPro-Type": "DOMAIN", "Beg": 142, "End": 268 }, { "InterPro-ID": "IPR001932", "InterPro-Name": "PPM-type_phosphatase-like_dom", "InterPro-Type": "DOMAIN", "Beg": 326, "End": 462 }, { "InterPro-ID": "IPR036457", "InterPro-Name": "PPM-type-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 134, "End": 471 }, { "InterPro-ID": "IPR000222", "InterPro-Name": "PP2C_BS", "InterPro-Type": "BINDING_SITE", "Beg": 199, "End": 207 }, { "InterPro-ID": "IPR001932", "InterPro-Name": "PPM-type_phosphatase-like_dom", "InterPro-Type": "DOMAIN", "Beg": 133, "End": 468 } ], "response#1": "MFSGSSSPPKDKSNSVPHSGAVDTQSLSVHPEEGSAAQTSKSLPSGGFFTRRTSEDQAPAGEKKRRSSTVTKAATFFTNAKNSLSLSSSPRESSSFNYTVRSPQTLQSLGSMDPALSVPQGSLNNSAGDSLPTPRSSFKVGVTEDRNRKCRRTMEDTHAYLYNFLGTPAPLARADGENEAGSSLAPDEASSVVETDNGYFAIFDGHAGTFAAEWCGKKLHLILEDIMKKNPNTPVPELLDQTFTTVDQQLEKLPVKNSGCTAVIALLRWEDRIPSSHSATGSSALAPAAAAAAAAKGDSNSEADDTPTQATSSGPSILPKLQEKAIRQRVLYTANVGDARIILCRNGKALRLSYDHKGSDENEGKRIANAGGLILNNRVNGVLAVTRALGDAYLKDLVTGHPYTTETVVQPDSDEFIILACDGLWDVCTDQEAVDLVRNVPDAQEASKILVDYALARFSTDNLSCMVIRLDTNRVKEVINKTAEPIGVAGDPSMDVEHGVSEADKIIEGARKSMANADIADDGETAEKGKNDILHKMVDGEPGPEMSLDDSNDAPTVSHLNKTNANNGIP", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more PPM-type_phosphatase-like_dom, PPM-type_phosphatase-like_dom, PPM-type_phosphatase-like_dom, PPM-type_phosphatase-like_dom, PPM-type_phosphatase-like_dom that are essential for its biological function; 2. The protein should belong to PP2C that shares evolutionary origin and functional similarity; 3. The protein should be classified within PPM-type-like_dom_sf, PPM-type-like_dom_sf sharing conserved structural features; 4. The protein should include a PP2C_BS that enables ligand binding under diverse conditions. The designed protein sequence is ", "reference": "MFSGSSSPPKDKSNSVPHSGAVDTQSLSVHPEEGSAAQTSKSLPSGGFFTRRTSEDQAPAGEKKRRSSTVTKAATFFTNAKNSLSLSSSPRESSSFNYTVRSPQTLQSLGSMDPALSVPQGSLNNSAGDSLPTPRSSFKVGVTEDRNRKCRRTMEDTHAYLYNFLGTPAPLARADGENEAGSSLAPDEASSVVETDNGYFAIFDGHAGTFAAEWCGKKLHLILEDIMKKNPNTPVPELLDQTFTTVDQQLEKLPVKNSGCTAVIALLRWEDRIPSSHSATGSSALAPAAAAAAAAKGDSNSEADDTPTQATSSGPSILPKLQEKAIRQRVLYTANVGDARIILCRNGKALRLSYDHKGSDENEGKRIANAGGLILNNRVNGVLAVTRALGDAYLKDLVTGHPYTTETVVQPDSDEFIILACDGLWDVCTDQEAVDLVRNVPDAQEASKILVDYALARFSTDNLSCMVIRLDTNRVKEVINKTAEPIGVAGDPSMDVEHGVSEADKIIEGARKSMANADIADDGETAEKGKNDILHKMVDGEPGPEMSLDDSNDAPTVSHLNKTNANNGIP" }, { "InterPro": [ { "InterPro-ID": "IPR013135", "InterPro-Name": "Vitelline_membr_Cys-rich-dom", "InterPro-Type": "DOMAIN", "Beg": 549, "End": 578 } ], "response#1": "MCGRRLLFLAAFGCLLANAFSLPATRNEEFDDGFPESEFDYEERHTREIPAQAYAPPIVYNSQSSYSPAKDQGYSAPAAPVYSPAAPSYSAPAAPSYSAPAAPSYSAPAAPSYSAPAAPSYSAPAAPSYSAPASSSYSAPAAPSYSAPAAPSYSAPAAPSYSAPASSSYSAPAAPSYSAPAAPSYSAPAAPSYSAPAAPSYSAPAAPSYSAPAAPSYSAPSAPSYSAQKTSSYSAPAAPSYHAPAAPASSYSAPAGPSYSAPAAPSYSAPSYSAPASSYSALKAPSYSAPAAPSYSAPAAPSYSSSASPSYSSPASSSYSAPAAPTYSAPKAQSYSAPAAPSYSAPAAPSYSAPASSSYSAPAAPSYSAPAAPSYSAPAAPSYSAPASSSYSAPAAPSYSAPAAPSYSAPASSSYSAPAAPSYSAPAAPSYSAPAAPSYSAPAAPSYSAPASSGYSAARAYSAGSAAPASGYSAPKTSSGYSAPASSGSPAASSYSAPASSTASSGYSAPASKSSGYARSEMDHQILGMARTAGGYGSAAPSAAYGAASLPSPPCPKNYVFSCSSVFTPAPCSQGYGY", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Vitelline_membr_Cys-rich-dom that are essential for its biological function. The designed protein sequence is ", "reference": "MCGRRLLFLAAFGCLLANAFSLPATRNEEFDDGFPESEFDYEERHTREIPAQAYAPPIVYNSQSSYSPAKDQGYSAPAAPVYSPAAPSYSAPAAPSYSAPAAPSYSAPAAPSYSAPAAPSYSAPAAPSYSAPASSSYSAPAAPSYSAPAAPSYSAPAAPSYSAPASSSYSAPAAPSYSAPAAPSYSAPAAPSYSAPAAPSYSAPAAPSYSAPAAPSYSAPSAPSYSAQKTSSYSAPAAPSYHAPAAPASSYSAPAGPSYSAPAAPSYSAPSYSAPASSYSALKAPSYSAPAAPSYSAPAAPSYSSSASPSYSSPASSSYSAPAAPTYSAPKAQSYSAPAAPSYSAPAAPSYSAPASSSYSAPAAPSYSAPAAPSYSAPAAPSYSAPASSSYSAPAAPSYSAPAAPSYSAPASSSYSAPAAPSYSAPAAPSYSAPAAPSYSAPAAPSYSAPASSGYSAARAYSAGSAAPASGYSAPKTSSGYSAPASSGSPAASSYSAPASSTASSGYSAPASKSSGYARSEMDHQILGMARTAGGYGSAAPSAAYGAASLPSPPCPKNYVFSCSSVFTPAPCSQGYGY" }, { "InterPro": [ { "InterPro-ID": "IPR019490", "InterPro-Name": "Glu6P/Mann6P_isomerase_C", "InterPro-Type": "DOMAIN", "Beg": 177, "End": 298 }, { "InterPro-ID": "IPR019490", "InterPro-Name": "Glu6P/Mann6P_isomerase_C", "InterPro-Type": "DOMAIN", "Beg": 177, "End": 285 }, { "InterPro-ID": "IPR046348", "InterPro-Name": "SIS_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 24, "End": 296 }, { "InterPro-ID": "IPR001347", "InterPro-Name": "SIS_dom", "InterPro-Type": "DOMAIN", "Beg": 27, "End": 177 } ], "response#1": "MLNDYLQWEKFILRGVEFPTRYRVDGDEVEITPSSRLYVSGMGGSGVVGDLIRDFSIVWNWDVEVTVVKDYFLRARDGLLIAVSYSGNTVETLYSVEYAKKRRIPTVAITTGGKLAQMGVPTIIIPKASAPRAALPQMLTAALHVVRKVYGIPIEIPEALEPPNDPLIHKLMEDFQKRPTIVAPETMRGVAYRVKNEFNENAKIEPSVEILPEAHHNWIEGSERPIVALTSPHIPREHQERVKATLEILGGTLYVVEMSTRGVLTFLREVGVASIKLAESRGVNPLATPRIEALKRRLQ", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Glu6P/Mann6P_isomerase_C, Glu6P/Mann6P_isomerase_C, SIS_dom that are essential for its biological function; 2. The protein should be classified within SIS_dom_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MLNDYLQWEKFILRGVEFPTRYRVDGDEVEITPSSRLYVSGMGGSGVVGDLIRDFSIVWNWDVEVTVVKDYFLRARDGLLIAVSYSGNTVETLYSVEYAKKRRIPTVAITTGGKLAQMGVPTIIIPKASAPRAALPQMLTAALHVVRKVYGIPIEIPEALEPPNDPLIHKLMEDFQKRPTIVAPETMRGVAYRVKNEFNENAKIEPSVEILPEAHHNWIEGSERPIVALTSPHIPREHQERVKATLEILGGTLYVVEMSTRGVLTFLREVGVASIKLAESRGVNPLATPRIEALKRRLQ" }, { "InterPro": [ { "InterPro-ID": "IPR050578", "InterPro-Name": "MARVEL-CKLF_proteins", "InterPro-Type": "FAMILY", "Beg": 13, "End": 162 }, { "InterPro-ID": "IPR008253", "InterPro-Name": "Marvel", "InterPro-Type": "DOMAIN", "Beg": 31, "End": 160 }, { "InterPro-ID": "IPR008253", "InterPro-Name": "Marvel", "InterPro-Type": "DOMAIN", "Beg": 31, "End": 154 }, { "InterPro-ID": "IPR013295", "InterPro-Name": "MAL", "InterPro-Type": "FAMILY", "Beg": 45, "End": 57 }, { "InterPro-ID": "IPR013295", "InterPro-Name": "MAL", "InterPro-Type": "FAMILY", "Beg": 99, "End": 114 }, { "InterPro-ID": "IPR013295", "InterPro-Name": "MAL", "InterPro-Type": "FAMILY", "Beg": 66, "End": 79 } ], "response#1": "MADFPGKVSTQTSSQEPQRSFAISSSVDMGFIKSIPGILLIAEIVVGLLVWTLIASTPHYLIPALGWVLFVSITLWLLSIALLVILLLSLHQRLPSVPWPLVLLVFYSVAALLYLTAFLANAATVPGGYYQGHLGASAFFGIVETLLYTASSYFAYLGWRGEGQNAAGSTVPV", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Marvel, Marvel that are essential for its biological function; 2. The protein should belong to MARVEL-CKLF_proteins, MAL, MAL, MAL that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MADFPGKVSTQTSSQEPQRSFAISSSVDMGFIKSIPGILLIAEIVVGLLVWTLIASTPHYLIPALGWVLFVSITLWLLSIALLVILLLSLHQRLPSVPWPLVLLVFYSVAALLYLTAFLANAATVPGGYYQGHLGASAFFGIVETLLYTASSYFAYLGWRGEGQNAAGSTVPV" }, { "InterPro": [ { "InterPro-ID": "IPR001604", "InterPro-Name": "Endo_G_ENPP1-like_dom", "InterPro-Type": "DOMAIN", "Beg": 126, "End": 365 }, { "InterPro-ID": "IPR040255", "InterPro-Name": "Non-specific_endonuclease", "InterPro-Type": "FAMILY", "Beg": 100, "End": 376 }, { "InterPro-ID": "IPR044925", "InterPro-Name": "His-Me_finger_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 121, "End": 369 }, { "InterPro-ID": "IPR044929", "InterPro-Name": "DNA/RNA_non-sp_Endonuclease_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 132, "End": 352 } ], "response#1": "MSLLYGLLILAFTRSCLVVGQCSINIPDDLKGEEAPVILVKTGNNVKLFRPEEKTTTFPKGTELLLACTGEGNGLKSNGQETTTLSCNGNQFESAAKEKLKDMSCKSMAKAVVEQTTKRCMGNDFNLYEAGYKVNGKFYGSVYDICYNGKGQSSGYTHNFIYGRTWKYKLPEKPYEHYSSRDPQAGKDLDKLYKEQKERFKNTKVNGKPLLDDEHYFTEGQLTPDTSIITGADKLSTYDYANIAPLFKDIYDGNIWRYENMTQELADQRQATFEEYTGGFYSYEVEKWKPIGLDNAEFPTHRVPKYIYKLVVDTESKDGIVFVTLNDPYHKSPASENLCKDICSEANINEPDFKNVEKGYTICCSYGDFGNRIRTLPKDIHVKGLLKY", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Endo_G_ENPP1-like_dom that are essential for its biological function; 2. The protein should belong to Non-specific_endonuclease that shares evolutionary origin and functional similarity; 3. The protein should be classified within His-Me_finger_sf, DNA/RNA_non-sp_Endonuclease_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MSLLYGLLILAFTRSCLVVGQCSINIPDDLKGEEAPVILVKTGNNVKLFRPEEKTTTFPKGTELLLACTGEGNGLKSNGQETTTLSCNGNQFESAAKEKLKDMSCKSMAKAVVEQTTKRCMGNDFNLYEAGYKVNGKFYGSVYDICYNGKGQSSGYTHNFIYGRTWKYKLPEKPYEHYSSRDPQAGKDLDKLYKEQKERFKNTKVNGKPLLDDEHYFTEGQLTPDTSIITGADKLSTYDYANIAPLFKDIYDGNIWRYENMTQELADQRQATFEEYTGGFYSYEVEKWKPIGLDNAEFPTHRVPKYIYKLVVDTESKDGIVFVTLNDPYHKSPASENLCKDICSEANINEPDFKNVEKGYTICCSYGDFGNRIRTLPKDIHVKGLLKY" }, { "InterPro": [ { "InterPro-ID": "IPR032345", "InterPro-Name": "PnbB", "InterPro-Type": "FAMILY", "Beg": 11, "End": 170 } ], "response#1": "MNKRDELIGLCIDFLAKVKDKTANANIERWLNENYGPDSETYQKISTLVIDGVAEGWAANDEISGPHYRRSRLCEPCAETFYFSITAVYMDSKGHELDNQQRTFRGDYHSHPYGELNMVIPLDEGAVLAGPLGWQGAGWTAPAPGSQHYPEVKNGALIAFFFLPAGRISYDFQAQG", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to PnbB that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MNKRDELIGLCIDFLAKVKDKTANANIERWLNENYGPDSETYQKISTLVIDGVAEGWAANDEISGPHYRRSRLCEPCAETFYFSITAVYMDSKGHELDNQQRTFRGDYHSHPYGELNMVIPLDEGAVLAGPLGWQGAGWTAPAPGSQHYPEVKNGALIAFFFLPAGRISYDFQAQG" }, { "InterPro": [ { "InterPro-ID": "IPR000415", "InterPro-Name": "Nitroreductase-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 3, "End": 218 }, { "InterPro-ID": "IPR000415", "InterPro-Name": "Nitroreductase-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 6, "End": 226 }, { "InterPro-ID": "IPR029479", "InterPro-Name": "Nitroreductase", "InterPro-Type": "DOMAIN", "Beg": 12, "End": 199 } ], "response#1": "MALLTDDFDAVVASRRAVRAFLPTPISRKLISEIIDIARLAPSNSNTQPWSIHVLTGEPKQALSALLGIAHNDPSADPLAHLPDDLARKYRERQEKWGELFYGLHQIDKCDDAGRARVSGLNFDFFGAPVGLIFTIDSNLKKYSWLDYGLFLQTLMLTARSRGLSTCPQVSFARFQSLIKDFLHLDDSQEIVCGMSLGYADENATVNSLRMPREMAQGFTHFMGFDR", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Nitroreductase that are essential for its biological function; 2. The protein should be classified within Nitroreductase-like, Nitroreductase-like sharing conserved structural features. The designed protein sequence is ", "reference": "MALLTDDFDAVVASRRAVRAFLPTPISRKLISEIIDIARLAPSNSNTQPWSIHVLTGEPKQALSALLGIAHNDPSADPLAHLPDDLARKYRERQEKWGELFYGLHQIDKCDDAGRARVSGLNFDFFGAPVGLIFTIDSNLKKYSWLDYGLFLQTLMLTARSRGLSTCPQVSFARFQSLIKDFLHLDDSQEIVCGMSLGYADENATVNSLRMPREMAQGFTHFMGFDR" }, { "InterPro": [ { "InterPro-ID": "IPR049546", "InterPro-Name": "WDR54_beta_propeller", "InterPro-Type": "DOMAIN", "Beg": 1, "End": 334 }, { "InterPro-ID": "IPR001680", "InterPro-Name": "WD40_rpt", "InterPro-Type": "REPEAT", "Beg": 153, "End": 197 }, { "InterPro-ID": "IPR001680", "InterPro-Name": "WD40_rpt", "InterPro-Type": "REPEAT", "Beg": 241, "End": 280 }, { "InterPro-ID": "IPR001680", "InterPro-Name": "WD40_rpt", "InterPro-Type": "REPEAT", "Beg": 201, "End": 238 }, { "InterPro-ID": "IPR001680", "InterPro-Name": "WD40_rpt", "InterPro-Type": "REPEAT", "Beg": 248, "End": 289 }, { "InterPro-ID": "IPR036322", "InterPro-Name": "WD40_repeat_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 129, "End": 324 }, { "InterPro-ID": "IPR015943", "InterPro-Name": "WD40/YVTN_repeat-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 71, "End": 324 } ], "response#1": "MFRRERSIPLRGSAAALSNNLSVLQLPARDLTHFGVVHGPSAQLLSAAPEGVPLAQRQLHVKEGAGVSPPLITQVHWCVLPFRVLLVLTSHRGIQMYESDGSVMVYWHALDSGDASSVQAMFARGIAASVHFICVGTWSGRILVFDIPAKGPNIVLNEELAGHQTPITDIATERAQGQDGVADMVTADDSGVLCVWRSGPEFTLLTRIAGFGVPCPSVQLWQGIVAAGYGNGQVRLYDAGTGALHIQISAHARTISALDLAPEVGKLLSAAEDTFVHIWKLNRNPESGSIEVEHCHGECISDTQVCGARFCDPGGSSFAVTGYDLAEILRFGSV", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more WDR54_beta_propeller that are essential for its biological function; 2. The protein should be classified within WD40_repeat_dom_sf, WD40/YVTN_repeat-like_dom_sf sharing conserved structural features; 3. The protein should include one or more WD40_rpt, WD40_rpt, WD40_rpt, WD40_rpt that provide structural or functional support. The designed protein sequence is ", "reference": "MFRRERSIPLRGSAAALSNNLSVLQLPARDLTHFGVVHGPSAQLLSAAPEGVPLAQRQLHVKEGAGVSPPLITQVHWCVLPFRVLLVLTSHRGIQMYESDGSVMVYWHALDSGDASSVQAMFARGIAASVHFICVGTWSGRILVFDIPAKGPNIVLNEELAGHQTPITDIATERAQGQDGVADMVTADDSGVLCVWRSGPEFTLLTRIAGFGVPCPSVQLWQGIVAAGYGNGQVRLYDAGTGALHIQISAHARTISALDLAPEVGKLLSAAEDTFVHIWKLNRNPESGSIEVEHCHGECISDTQVCGARFCDPGGSSFAVTGYDLAEILRFGSV" }, { "InterPro": [ { "InterPro-ID": "IPR000534", "InterPro-Name": "Semialdehyde_DH_NAD-bd", "InterPro-Type": "DOMAIN", "Beg": 5, "End": 132 }, { "InterPro-ID": "IPR051823", "InterPro-Name": "ASADH-related", "InterPro-Type": "FAMILY", "Beg": 2, "End": 365 }, { "InterPro-ID": "IPR000319", "InterPro-Name": "Asp-semialdehyde_DH_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 243, "End": 257 }, { "InterPro-ID": "IPR005676", "InterPro-Name": "Asp_semi-ald_DH_pep-lack", "InterPro-Type": "FAMILY", "Beg": 5, "End": 360 }, { "InterPro-ID": "IPR012280", "InterPro-Name": "Semialdhyde_DH_dimer_dom", "InterPro-Type": "DOMAIN", "Beg": 165, "End": 345 }, { "InterPro-ID": "IPR036291", "InterPro-Name": "NAD(P)-bd_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 5, "End": 174 }, { "InterPro-ID": "IPR000534", "InterPro-Name": "Semialdehyde_DH_NAD-bd", "InterPro-Type": "DOMAIN", "Beg": 5, "End": 130 } ], "response#1": "MSVKKAGVLGATGSVGQRFILLLSKHPEFEIHALGASSRSAGKKYKDAASWKQTETLPETEQDIVVQECKPEGNFLECDVVFSGLDADVAGDIEKSFVEAGLAVVSNAKNYRREKDVPLVVPIVNPEHIDVVENKVKQAVSKGGKKPGFIICISNCSTAGLVAPLKPLVEKFGPIDALTTTTLQAISGAGFSPGVSGMDILDNIVPYISGEEDKLEWETKKILGGVNAEGTEFVPIPESEMKVSAQCNRVPVIDGHTECISLRFANRPAPSVEDVKQCLREYECAASKLGCHSAPKQTIHVLDQPDRPQPRLDRDRDSGYGVSVGRIREDSLLDFKMVVLSHNTIIGAAGAGILIAEILKAKNII", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Semialdehyde_DH_NAD-bd, Semialdhyde_DH_dimer_dom, Semialdehyde_DH_NAD-bd that are essential for its biological function; 2. The protein should belong to ASADH-related, Asp_semi-ald_DH_pep-lack that shares evolutionary origin and functional similarity; 3. The protein should be classified within NAD(P)-bd_dom_sf sharing conserved structural features; 4. The protein should contain Asp-semialdehyde_DH_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MSVKKAGVLGATGSVGQRFILLLSKHPEFEIHALGASSRSAGKKYKDAASWKQTETLPETEQDIVVQECKPEGNFLECDVVFSGLDADVAGDIEKSFVEAGLAVVSNAKNYRREKDVPLVVPIVNPEHIDVVENKVKQAVSKGGKKPGFIICISNCSTAGLVAPLKPLVEKFGPIDALTTTTLQAISGAGFSPGVSGMDILDNIVPYISGEEDKLEWETKKILGGVNAEGTEFVPIPESEMKVSAQCNRVPVIDGHTECISLRFANRPAPSVEDVKQCLREYECAASKLGCHSAPKQTIHVLDQPDRPQPRLDRDRDSGYGVSVGRIREDSLLDFKMVVLSHNTIIGAAGAGILIAEILKAKNII" }, { "InterPro": [ { "InterPro-ID": "IPR011032", "InterPro-Name": "GroES-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1488, "End": 1623 }, { "InterPro-ID": "IPR014043", "InterPro-Name": "Acyl_transferase_dom", "InterPro-Type": "DOMAIN", "Beg": 541, "End": 857 }, { "InterPro-ID": "IPR020841", "InterPro-Name": "PKS_Beta-ketoAc_synthase_dom", "InterPro-Type": "DOMAIN", "Beg": 9, "End": 434 }, { "InterPro-ID": "IPR013968", "InterPro-Name": "PKS_KR", "InterPro-Type": "DOMAIN", "Beg": 1828, "End": 2005 }, { "InterPro-ID": "IPR049551", "InterPro-Name": "PKS_DH_C", "InterPro-Type": "DOMAIN", "Beg": 1084, "End": 1243 }, { "InterPro-ID": "IPR036291", "InterPro-Name": "NAD(P)-bd_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1827, "End": 2041 }, { "InterPro-ID": "IPR014043", "InterPro-Name": "Acyl_transferase_dom", "InterPro-Type": "DOMAIN", "Beg": 542, "End": 855 }, { "InterPro-ID": "IPR020807", "InterPro-Name": "PKS_DH", "InterPro-Type": "DOMAIN", "Beg": 925, "End": 1115 }, { "InterPro-ID": "IPR050091", "InterPro-Name": "PKS_NRPS_Biosynth_Enz", "InterPro-Type": "FAMILY", "Beg": 8, "End": 2183 }, { "InterPro-ID": "IPR032821", "InterPro-Name": "PKS_assoc", "InterPro-Type": "DOMAIN", "Beg": 387, "End": 480 }, { "InterPro-ID": "IPR020841", "InterPro-Name": "PKS_Beta-ketoAc_synthase_dom", "InterPro-Type": "DOMAIN", "Beg": 6, "End": 431 }, { "InterPro-ID": "IPR036291", "InterPro-Name": "NAD(P)-bd_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1590, "End": 1750 }, { "InterPro-ID": "IPR016039", "InterPro-Name": "Thiolase-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 7, "End": 429 }, { "InterPro-ID": "IPR036736", "InterPro-Name": "ACP-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 2110, "End": 2181 }, { "InterPro-ID": "IPR049900", "InterPro-Name": "PKS_mFAS_DH", "InterPro-Type": "DOMAIN", "Beg": 925, "End": 1246 }, { "InterPro-ID": "IPR009081", "InterPro-Name": "PP-bd_ACP", "InterPro-Type": "DOMAIN", "Beg": 2107, "End": 2184 }, { "InterPro-ID": "IPR020806", "InterPro-Name": "PKS_PP-bd", "InterPro-Type": "DOMAIN", "Beg": 2113, "End": 2184 }, { "InterPro-ID": "IPR014031", "InterPro-Name": "Ketoacyl_synth_C", "InterPro-Type": "DOMAIN", "Beg": 267, "End": 384 }, { "InterPro-ID": "IPR042104", "InterPro-Name": "PKS_dehydratase_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 921, "End": 1246 }, { "InterPro-ID": "IPR016039", "InterPro-Name": "Thiolase-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 2, "End": 454 }, { "InterPro-ID": "IPR016035", "InterPro-Name": "Acyl_Trfase/lysoPLipase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 540, "End": 839 }, { "InterPro-ID": "IPR016036", "InterPro-Name": "Malonyl_transacylase_ACP-bd", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 673, "End": 737 }, { "InterPro-ID": "IPR013154", "InterPro-Name": "ADH-like_N", "InterPro-Type": "DOMAIN", "Beg": 1511, "End": 1582 }, { "InterPro-ID": "IPR020843", "InterPro-Name": "PKS_ER", "InterPro-Type": "DOMAIN", "Beg": 1494, "End": 1804 }, { "InterPro-ID": "IPR001227", "InterPro-Name": "Ac_transferase_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 540, "End": 858 }, { "InterPro-ID": "IPR009081", "InterPro-Name": "PP-bd_ACP", "InterPro-Type": "DOMAIN", "Beg": 2111, "End": 2185 }, { "InterPro-ID": "IPR049552", "InterPro-Name": "PKS_DH_N", "InterPro-Type": "DOMAIN", "Beg": 927, "End": 1021 }, { "InterPro-ID": "IPR014030", "InterPro-Name": "Ketoacyl_synth_N", "InterPro-Type": "DOMAIN", "Beg": 8, "End": 257 }, { "InterPro-ID": "IPR018201", "InterPro-Name": "Ketoacyl_synth_AS", "InterPro-Type": "ACTIVE_SITE", "Beg": 170, "End": 186 }, { "InterPro-ID": "IPR036736", "InterPro-Name": "ACP-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 2114, "End": 2188 } ], "response#1": "MASSALTPVAIVGYACKLPGDVSSPDDLWELCSRGRTGWGPTPSTRYSKDAYYHPAPGKHGCINTEGGYFLKEDPARFDAPFFNMTIQEATALDPQQRLLLECTFEAFENSGMTKEGIAGKDIGVFVGGSFADYEVNNTRDIDTAPTYQATGCAPAMQSNRLSYYFDLRGPSMTVDTACSSSLVALHSAMQSLRNGESSSAVVAAAHLNLTPDFFVTMSNTQLLNDAGKTFAFDHRAISGFARGEGAGSMILKPLDAAIRDGDVIRAVIHNSGVNQDGKTNGITVPNGRAQSDLIKQVYSKAGLDPAECGFSECHGTGTKVGDPIEVAGIHEALGAGRSPRNPLFIGSVKSNVGHLEGASGIVSVIKAAMMLEKGMVLPNANFETANPNIPLEQYNMKVPTSTRPWPRGKKYVSVSNYGFGGANAHVVLGAAPKGLKTTMTTIRSLEDAPEEPLCKLFVLSAHDSQALQKEITDLGVFLEQRPEVFEKLLAGNVAYTLGERRSHLPCRLAIAAVSSDELGQSLATTKVPTFRARNEPTLGFVFTGQGAQWATMGAELARDYPIFAAALDTADDTLKALGADFSLKEEMLKPADISLINAAHISQPACTALQIALTMLLSSWGIHPAAVVGHSSGEIGCAFAAGIIGLEDAMKIAYYRGQCMLSLKKKAVGKPQGTMMAVGTSAENVRPLLDAVSKGYITVACINSPASVTLSGDVEAVEELQPILTEKSIFNRQLKVGVAYHSAHLEPVVDEYLDLIKNIQPASTATATFYSSLLGRVAEASELTPEYWVQNLTSPVRFSGGLSAMARETGSKTIDHLVELGPHSALQGPIRDTLATIDAAKGKMHYVSVLARGQNASECALRMAGALYMKGLSLTFGEINFPRTKSVNQKLITDLPRYPFNHETRYWHESRLAQKHCFKEGGRNDLLGSLADWSNDLEPTWRNIVKLDDLPFLRSHKMQDMPVFPMAGYMGMALEAAARRAIARGVQFDRFEIREFVVSSALVFNEDTDVEMTITLKPYSEGLRGAASDLWDDYKICSWDAKRGWLQHCHGLVGVRNSPAANAVDAHRIQSASKAFEACKASIISASTETVDVQAMYNTLTTIGAGYGPVFTGLEPCQASDTTAHAQLVVPDTKSLMPKGYETELIVHPALLDQIIQIVWPIFGAGRQGLDTLYMPTFVKNFSISRNFASMLGNGLEVFGAGAPNNEAPEPTKFGFFVVGSSDASEPLVQFDGLTMTPLRESSGSSGPQARELCYKIDWQTVSDEDIGLEKSSSDASDTPIKADSLVSTPFTRDEAVCVVYNKATEKDLAAEVADNVWKTSGVQAELVTLSKVIPADKRVIFVSTGNNVLSGIDATMFGTLRQMLLSARKVLWIYKEGPDVDDVDGSMVVGFTRAIRSETSANIVTLGLQQATGKTLVENIFTVLTKTSADSPSTFKDDKEFILKGDDLLVPKVVDDEELNVRLHQESQDSVIYQQPFAQSDRRLKMVIATLGSLDSFYFVDDEPKPLNDNEVEIEVKATGMNFKDVVVSMGQLNQPYIGVECAGVIAAVGKKVTDVKVGQSVMAMTEGAYSTYARCLSTSVAPLPEKMDFTAASTIPVVFCTAYYGLFDLGRLTEGESVLIHAAAGGVGQAAIMLAQTCGAEIFATVGSLDKKQHIVKEYGIPEDHIFYSRDTAFGPAIRQVTGGKGVDVVLNSLGGDFLRESWDCLAPFGRFIEIGKADITKNSRLEMAQFEYNVSFASVDLTKVAAYKPKLMKRLLNDVEKLMSSGSIRPVGPITSYGINDVEAAFRSLQSGKSMGKLVIAPQSGDSVQAIAPKKTATLFKEDASYLIVGGTGGLGCSIARWMASRGAKHICLSSRRANITPRLEALITDLSILGTKVSVRACDVADAGSVETLVKDLKKESPIRGVIQGAMVLKDVLYEQMTLDDFSAVVNPKVAGTLNLHNSLGTSELDFFIALSSVAGVVGNRGQAAYAAANVFLDTFMAHRKAQGLPGTSLDLTAVSDVGYLADNSERAADVLRNLGGETIEESEILGLLTAAVTGKITASNNHVITGLKINPGSEPFWCHDAKFSNLLAAAASQSSAEGGNANIPLPQALKSAANGEKALEVLYGALVTKLAAVLMLSVEEMEPSAAVASYSLDSLAAIEVRNWIAREADANVQVLELLTSPSLMELAKLISKKSKLVSFE", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Acyl_transferase_dom, PKS_Beta-ketoAc_synthase_dom, PKS_KR, PKS_DH_C, Acyl_transferase_dom, PKS_DH, PKS_assoc, PKS_Beta-ketoAc_synthase_dom, PKS_mFAS_DH, PP-bd_ACP, PKS_PP-bd, Ketoacyl_synth_C, ADH-like_N, PKS_ER, PP-bd_ACP, PKS_DH_N, Ketoacyl_synth_N that are essential for its biological function; 2. The protein should belong to PKS_NRPS_Biosynth_Enz that shares evolutionary origin and functional similarity; 3. The protein should be classified within GroES-like_sf, NAD(P)-bd_dom_sf, NAD(P)-bd_dom_sf, Thiolase-like, ACP-like_sf, PKS_dehydratase_sf, Thiolase-like, Acyl_Trfase/lysoPLipase, Malonyl_transacylase_ACP-bd, Ac_transferase_dom_sf, ACP-like_sf sharing conserved structural features; 4. The protein must have Ketoacyl_synth_AS that is conserved among related catalytic enzymes. The designed protein sequence is ", "reference": "MASSALTPVAIVGYACKLPGDVSSPDDLWELCSRGRTGWGPTPSTRYSKDAYYHPAPGKHGCINTEGGYFLKEDPARFDAPFFNMTIQEATALDPQQRLLLECTFEAFENSGMTKEGIAGKDIGVFVGGSFADYEVNNTRDIDTAPTYQATGCAPAMQSNRLSYYFDLRGPSMTVDTACSSSLVALHSAMQSLRNGESSSAVVAAAHLNLTPDFFVTMSNTQLLNDAGKTFAFDHRAISGFARGEGAGSMILKPLDAAIRDGDVIRAVIHNSGVNQDGKTNGITVPNGRAQSDLIKQVYSKAGLDPAECGFSECHGTGTKVGDPIEVAGIHEALGAGRSPRNPLFIGSVKSNVGHLEGASGIVSVIKAAMMLEKGMVLPNANFETANPNIPLEQYNMKVPTSTRPWPRGKKYVSVSNYGFGGANAHVVLGAAPKGLKTTMTTIRSLEDAPEEPLCKLFVLSAHDSQALQKEITDLGVFLEQRPEVFEKLLAGNVAYTLGERRSHLPCRLAIAAVSSDELGQSLATTKVPTFRARNEPTLGFVFTGQGAQWATMGAELARDYPIFAAALDTADDTLKALGADFSLKEEMLKPADISLINAAHISQPACTALQIALTMLLSSWGIHPAAVVGHSSGEIGCAFAAGIIGLEDAMKIAYYRGQCMLSLKKKAVGKPQGTMMAVGTSAENVRPLLDAVSKGYITVACINSPASVTLSGDVEAVEELQPILTEKSIFNRQLKVGVAYHSAHLEPVVDEYLDLIKNIQPASTATATFYSSLLGRVAEASELTPEYWVQNLTSPVRFSGGLSAMARETGSKTIDHLVELGPHSALQGPIRDTLATIDAAKGKMHYVSVLARGQNASECALRMAGALYMKGLSLTFGEINFPRTKSVNQKLITDLPRYPFNHETRYWHESRLAQKHCFKEGGRNDLLGSLADWSNDLEPTWRNIVKLDDLPFLRSHKMQDMPVFPMAGYMGMALEAAARRAIARGVQFDRFEIREFVVSSALVFNEDTDVEMTITLKPYSEGLRGAASDLWDDYKICSWDAKRGWLQHCHGLVGVRNSPAANAVDAHRIQSASKAFEACKASIISASTETVDVQAMYNTLTTIGAGYGPVFTGLEPCQASDTTAHAQLVVPDTKSLMPKGYETELIVHPALLDQIIQIVWPIFGAGRQGLDTLYMPTFVKNFSISRNFASMLGNGLEVFGAGAPNNEAPEPTKFGFFVVGSSDASEPLVQFDGLTMTPLRESSGSSGPQARELCYKIDWQTVSDEDIGLEKSSSDASDTPIKADSLVSTPFTRDEAVCVVYNKATEKDLAAEVADNVWKTSGVQAELVTLSKVIPADKRVIFVSTGNNVLSGIDATMFGTLRQMLLSARKVLWIYKEGPDVDDVDGSMVVGFTRAIRSETSANIVTLGLQQATGKTLVENIFTVLTKTSADSPSTFKDDKEFILKGDDLLVPKVVDDEELNVRLHQESQDSVIYQQPFAQSDRRLKMVIATLGSLDSFYFVDDEPKPLNDNEVEIEVKATGMNFKDVVVSMGQLNQPYIGVECAGVIAAVGKKVTDVKVGQSVMAMTEGAYSTYARCLSTSVAPLPEKMDFTAASTIPVVFCTAYYGLFDLGRLTEGESVLIHAAAGGVGQAAIMLAQTCGAEIFATVGSLDKKQHIVKEYGIPEDHIFYSRDTAFGPAIRQVTGGKGVDVVLNSLGGDFLRESWDCLAPFGRFIEIGKADITKNSRLEMAQFEYNVSFASVDLTKVAAYKPKLMKRLLNDVEKLMSSGSIRPVGPITSYGINDVEAAFRSLQSGKSMGKLVIAPQSGDSVQAIAPKKTATLFKEDASYLIVGGTGGLGCSIARWMASRGAKHICLSSRRANITPRLEALITDLSILGTKVSVRACDVADAGSVETLVKDLKKESPIRGVIQGAMVLKDVLYEQMTLDDFSAVVNPKVAGTLNLHNSLGTSELDFFIALSSVAGVVGNRGQAAYAAANVFLDTFMAHRKAQGLPGTSLDLTAVSDVGYLADNSERAADVLRNLGGETIEESEILGLLTAAVTGKITASNNHVITGLKINPGSEPFWCHDAKFSNLLAAAASQSSAEGGNANIPLPQALKSAANGEKALEVLYGALVTKLAAVLMLSVEEMEPSAAVASYSLDSLAAIEVRNWIAREADANVQVLELLTSPSLMELAKLISKKSKLVSFE" }, { "InterPro": [ { "InterPro-ID": "IPR036526", "InterPro-Name": "C-N_Hydrolase_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 7, "End": 257 }, { "InterPro-ID": "IPR014445", "InterPro-Name": "Gln-dep_NAD_synthase", "InterPro-Type": "FAMILY", "Beg": 11, "End": 551 }, { "InterPro-ID": "IPR022310", "InterPro-Name": "NAD/GMP_synthase", "InterPro-Type": "DOMAIN", "Beg": 276, "End": 526 }, { "InterPro-ID": "IPR036526", "InterPro-Name": "C-N_Hydrolase_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 10, "End": 251 }, { "InterPro-ID": "IPR003694", "InterPro-Name": "NAD_synthase", "InterPro-Type": "FAMILY", "Beg": 276, "End": 523 }, { "InterPro-ID": "IPR003010", "InterPro-Name": "C-N_Hydrolase", "InterPro-Type": "DOMAIN", "Beg": 12, "End": 244 }, { "InterPro-ID": "IPR014445", "InterPro-Name": "Gln-dep_NAD_synthase", "InterPro-Type": "FAMILY", "Beg": 8, "End": 552 }, { "InterPro-ID": "IPR003694", "InterPro-Name": "NAD_synthase", "InterPro-Type": "FAMILY", "Beg": 283, "End": 531 }, { "InterPro-ID": "IPR003010", "InterPro-Name": "C-N_Hydrolase", "InterPro-Type": "DOMAIN", "Beg": 11, "End": 253 }, { "InterPro-ID": "IPR014729", "InterPro-Name": "Rossmann-like_a/b/a_fold", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 273, "End": 552 }, { "InterPro-ID": "IPR003694", "InterPro-Name": "NAD_synthase", "InterPro-Type": "FAMILY", "Beg": 276, "End": 547 } ], "response#1": "MMESAVTAHTLRIAMAQFDFPVGAVTQNTDRIIEYIAAARDEFEADIVLFPELAISGYPPEDLLLRPGFLAHCEQALARIAAATRGIVAVVGWPQSAGSVVYNAASVLREGRIEATYRKRELPNYAVFDERRYFDVDPDGDNCVVTVKGVQVGVVICEDLWFAEPLAKTVQAGAELVLVPNASPYERGKHAQRDALLAERTRESGAAIAYLNVVGGQDALVFDGASVVADGDGTVHPAAAAFVDQWLVVDYAAGERSFTPVVWVDDGDESMDALAWRAVVRGLKDYCGKNGFRKVWLGLSGGIDSALVLAMAVDALGGENVTAVRLPSRYTAGLSNDLADEQCRALGVKLETIAIEPAFEGLLAALGPLFADTQPDITEENLQSRSRGVILMALSNKFGGLVLTTGNKSEYAVGYATIYGDMCGGYAPLKDLYKTEVFGLAKWRNTVGGAPVIPPAVISRPPSAELRDNQTDQDSLPPYDVLDGILYRYVDQEQSRDDIVAAGYAADTVEHVLRLVRLNEWKRHQAAPGPKVSRRAFGRERRYPITNGYSGQ", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more NAD/GMP_synthase, C-N_Hydrolase, C-N_Hydrolase that are essential for its biological function; 2. The protein should belong to Gln-dep_NAD_synthase, NAD_synthase, Gln-dep_NAD_synthase, NAD_synthase, NAD_synthase that shares evolutionary origin and functional similarity; 3. The protein should be classified within C-N_Hydrolase_sf, C-N_Hydrolase_sf, Rossmann-like_a/b/a_fold sharing conserved structural features. The designed protein sequence is ", "reference": "MMESAVTAHTLRIAMAQFDFPVGAVTQNTDRIIEYIAAARDEFEADIVLFPELAISGYPPEDLLLRPGFLAHCEQALARIAAATRGIVAVVGWPQSAGSVVYNAASVLREGRIEATYRKRELPNYAVFDERRYFDVDPDGDNCVVTVKGVQVGVVICEDLWFAEPLAKTVQAGAELVLVPNASPYERGKHAQRDALLAERTRESGAAIAYLNVVGGQDALVFDGASVVADGDGTVHPAAAAFVDQWLVVDYAAGERSFTPVVWVDDGDESMDALAWRAVVRGLKDYCGKNGFRKVWLGLSGGIDSALVLAMAVDALGGENVTAVRLPSRYTAGLSNDLADEQCRALGVKLETIAIEPAFEGLLAALGPLFADTQPDITEENLQSRSRGVILMALSNKFGGLVLTTGNKSEYAVGYATIYGDMCGGYAPLKDLYKTEVFGLAKWRNTVGGAPVIPPAVISRPPSAELRDNQTDQDSLPPYDVLDGILYRYVDQEQSRDDIVAAGYAADTVEHVLRLVRLNEWKRHQAAPGPKVSRRAFGRERRYPITNGYSGQ" }, { "InterPro": [ { "InterPro-ID": "IPR007934", "InterPro-Name": "AbfB_ABD", "InterPro-Type": "DOMAIN", "Beg": 368, "End": 469 }, { "InterPro-ID": "IPR006710", "InterPro-Name": "Glyco_hydro_43", "InterPro-Type": "FAMILY", "Beg": 34, "End": 326 }, { "InterPro-ID": "IPR023296", "InterPro-Name": "Glyco_hydro_beta-prop_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 24, "End": 335 }, { "InterPro-ID": "IPR023296", "InterPro-Name": "Glyco_hydro_beta-prop_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 32, "End": 335 }, { "InterPro-ID": "IPR036195", "InterPro-Name": "AbfB_ABD_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 343, "End": 479 } ], "response#1": "MRFSVFTAAIAAAFSACCATASPAVNYVNSLILQRADPHIVKHTDGWYYFTATVPEYDRIVLRRAQTIQGLQSAPETVIWRRKAFGVGSGQVWAPELHYIDGRWYIYVALGVSGQWRIRAFVLEGVGANPLTASWTEKGIIQTNWDTFSLDATTFVANGTRYLVWAQQDPSRNGENSSLFIAPLQNPWTIRGPAVAISHPDLSWERIGYKVNEGPAVIQRNGRIFLTYSASATDHNYCMGLLTARADANLMNPASWVKSQQPIFVSNAATNQWGPGHNQFTVSEDGLSDILVYHDRGYRDINGDPLNDPNRRTRVQKLYWRDDGTPDFGIPVPDGPTPVRLRVAANGASSNGAYVRFYTTTGSGNLTGTAALPDTQFKLVSPGLSGGDSVSLESTSNPGTYVRRVSGSTAVQFERGTALNTAALRASASFRRVPGLSDSGGAVSFESVESPGQYLRLDPNGRLSVASVAEGTQGRSTFYLE", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more AbfB_ABD that are essential for its biological function; 2. The protein should belong to Glyco_hydro_43 that shares evolutionary origin and functional similarity; 3. The protein should be classified within Glyco_hydro_beta-prop_sf, Glyco_hydro_beta-prop_sf, AbfB_ABD_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MRFSVFTAAIAAAFSACCATASPAVNYVNSLILQRADPHIVKHTDGWYYFTATVPEYDRIVLRRAQTIQGLQSAPETVIWRRKAFGVGSGQVWAPELHYIDGRWYIYVALGVSGQWRIRAFVLEGVGANPLTASWTEKGIIQTNWDTFSLDATTFVANGTRYLVWAQQDPSRNGENSSLFIAPLQNPWTIRGPAVAISHPDLSWERIGYKVNEGPAVIQRNGRIFLTYSASATDHNYCMGLLTARADANLMNPASWVKSQQPIFVSNAATNQWGPGHNQFTVSEDGLSDILVYHDRGYRDINGDPLNDPNRRTRVQKLYWRDDGTPDFGIPVPDGPTPVRLRVAANGASSNGAYVRFYTTTGSGNLTGTAALPDTQFKLVSPGLSGGDSVSLESTSNPGTYVRRVSGSTAVQFERGTALNTAALRASASFRRVPGLSDSGGAVSFESVESPGQYLRLDPNGRLSVASVAEGTQGRSTFYLE" }, { "InterPro": [ { "InterPro-ID": "IPR016181", "InterPro-Name": "Acyl_CoA_acyltransferase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 25, "End": 151 }, { "InterPro-ID": "IPR000182", "InterPro-Name": "GNAT_dom", "InterPro-Type": "DOMAIN", "Beg": 85, "End": 143 } ], "response#1": "MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDPIPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLVESV", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more GNAT_dom that are essential for its biological function; 2. The protein should be classified within Acyl_CoA_acyltransferase sharing conserved structural features. The designed protein sequence is ", "reference": "MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDPIPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLVESV" }, { "InterPro": [ { "InterPro-ID": "IPR014795", "InterPro-Name": "TacA_1-like", "InterPro-Type": "FAMILY", "Beg": 2, "End": 95 }, { "InterPro-ID": "IPR014795", "InterPro-Name": "TacA_1-like", "InterPro-Type": "FAMILY", "Beg": 14, "End": 88 }, { "InterPro-ID": "IPR010985", "InterPro-Name": "Ribbon_hlx_hlx", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 9, "End": 87 } ], "response#1": "MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPNAALRKTMQTPAPWEQEK", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to TacA_1-like, TacA_1-like that shares evolutionary origin and functional similarity; 2. The protein should be classified within Ribbon_hlx_hlx sharing conserved structural features. The designed protein sequence is ", "reference": "MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPNAALRKTMQTPAPWEQEK" }, { "InterPro": [ { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 438, "End": 692 }, { "InterPro-ID": "IPR003439", "InterPro-Name": "ABC_transporter-like_ATP-bd", "InterPro-Type": "DOMAIN", "Beg": 1123, "End": 1274 }, { "InterPro-ID": "IPR003593", "InterPro-Name": "AAA+_ATPase", "InterPro-Type": "DOMAIN", "Beg": 473, "End": 674 }, { "InterPro-ID": "IPR003593", "InterPro-Name": "AAA+_ATPase", "InterPro-Type": "DOMAIN", "Beg": 1132, "End": 1326 }, { "InterPro-ID": "IPR036640", "InterPro-Name": "ABC1_TM_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 170, "End": 1078 }, { "InterPro-ID": "IPR011527", "InterPro-Name": "ABC1_TM_dom", "InterPro-Type": "DOMAIN", "Beg": 121, "End": 411 }, { "InterPro-ID": "IPR011527", "InterPro-Name": "ABC1_TM_dom", "InterPro-Type": "DOMAIN", "Beg": 121, "End": 395 }, { "InterPro-ID": "IPR011527", "InterPro-Name": "ABC1_TM_dom", "InterPro-Type": "DOMAIN", "Beg": 778, "End": 1055 }, { "InterPro-ID": "IPR017871", "InterPro-Name": "ABC_transporter-like_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 594, "End": 608 }, { "InterPro-ID": "IPR003439", "InterPro-Name": "ABC_transporter-like_ATP-bd", "InterPro-Type": "DOMAIN", "Beg": 1105, "End": 1343 }, { "InterPro-ID": "IPR003439", "InterPro-Name": "ABC_transporter-like_ATP-bd", "InterPro-Type": "DOMAIN", "Beg": 446, "End": 691 }, { "InterPro-ID": "IPR036640", "InterPro-Name": "ABC1_TM_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 108, "End": 430 }, { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 444, "End": 705 }, { "InterPro-ID": "IPR017871", "InterPro-Name": "ABC_transporter-like_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 1246, "End": 1260 }, { "InterPro-ID": "IPR039421", "InterPro-Name": "Type_1_exporter", "InterPro-Type": "FAMILY", "Beg": 51, "End": 693 }, { "InterPro-ID": "IPR036640", "InterPro-Name": "ABC1_TM_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 769, "End": 1087 }, { "InterPro-ID": "IPR003439", "InterPro-Name": "ABC_transporter-like_ATP-bd", "InterPro-Type": "DOMAIN", "Beg": 465, "End": 622 }, { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1096, "End": 1344 }, { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1095, "End": 1349 }, { "InterPro-ID": "IPR011527", "InterPro-Name": "ABC1_TM_dom", "InterPro-Type": "DOMAIN", "Beg": 779, "End": 1070 } ], "response#1": "MDTVHEGHHGSDSSSSGDTVNVEVTNYEKTQLGQAPLPLAPAPTPAVPVNEKKHKSQKEKKHKGQNEKQDKDSDDEGEDPFAHLPDHEKAVLKRQLDIPTVKVTYFMLFRYATLNDKLLMVLSALSSIIGGALLPLMTIVFGGLTTTFKDFFRQTITQEHFNHELSRFSLYFLYLAIGEFVFVYIATAGFLYTGEHVAGKIRENFLKAILRQNIAFFDQLGAGEITTRITSDTNLVQDGISEKVGLTLTALATFITAFVVSFIKDWKLTLILMSTVFAIVFTMGGMSGFIVKFNKASLASYAEGGTVAEEVISSVRNAKAFNTEAKLTRAYDAHLAVAEKWGFKMKAVTGSMIGFLMCYVYLNYSLAFWMGSRYLVSGRIEVGDVLTIILSIMIGAFALGNVAPNIQAFTTSVAAAAKIFATIDRVSPLDPSSESGETLKSVEGHIELRNIRHIYPSRPEVTVMEDVSLIVPAGKTTALVGESGSGKSTIVGLVERFYDPVGGTVYLDGQDISSLNLRWLRRQISLVSQEPTLFATTIFGNIRHGLIGTAYESESEEKIRELVENAARFANAHDFITGLPEGYATNVGERGFLLSGGQKQRIAIARAMVSDPKILLLDEATSALDTKSEGVVQAALDKAALGRTTIVIAHRLSTIKGADNIVVMSRGRIVEQGTHDALLEKQGAYYNLVEAQRIAAENENKDQEEVAILDEKDQNLKHETTKGEQPEDGLKLARTQTGKSQSSIVLADKKAEVENRYSLWTLIKVVAVFNRQEWLYMTIGIICSVITGGGNPTQAVFFAKAVTALSGDNSTPQGKATIRSQANFWSWMYFMLALVQFSAFLIQGYVFAVCSERLVHRAREQAFKTMLRQDIAFFDKEENTAGALTSFLSTETTHLAGMSGVTLGTILSVIVTLVAAFSVSLAIQWKLSLVCISTVPILLACGFLRFWMLARFQATAKKAYEKSASYACEATSAIRTVASLTREDDVHLHYHDQLVDQERKSLISILRSSSLYAASQSLIFCCTALGFWYGGTLIAKKEIGQFQFFLCFSAVIFGAQSAGTIFSFAPDMGKAKQAAAELKALFDRKPEIDSWSEDGEQLSSVEGHIEFRDVHFRYPTRPEQPVLRGLNLTVKPGQYVALVGASGCGKSTTIQLLERFYDPLAGGVYIDGKEVSSLNVNNYRSWIALVSQEPTLYQGTVKENILLGADRENVPQEAIEQACRDANIYDFIMSLPDAFDTIVGSKGSMLSGGQKQRIAIARALLRDPKILLLDEATSALDSESEKVVQAALDKAAKGRTTIAVAHRLSTIQRADMIYVFDAGKVVESGTHTELIHLRGRYWELVNLQSLGKAQ", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more ABC_transporter-like_ATP-bd, AAA+_ATPase, AAA+_ATPase, ABC1_TM_dom, ABC1_TM_dom, ABC1_TM_dom, ABC_transporter-like_ATP-bd, ABC_transporter-like_ATP-bd, ABC_transporter-like_ATP-bd, ABC1_TM_dom that are essential for its biological function; 2. The protein should belong to Type_1_exporter that shares evolutionary origin and functional similarity; 3. The protein should be classified within P-loop_NTPase, ABC1_TM_sf, ABC1_TM_sf, P-loop_NTPase, ABC1_TM_sf, P-loop_NTPase, P-loop_NTPase sharing conserved structural features; 4. The protein should contain ABC_transporter-like_CS, ABC_transporter-like_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MDTVHEGHHGSDSSSSGDTVNVEVTNYEKTQLGQAPLPLAPAPTPAVPVNEKKHKSQKEKKHKGQNEKQDKDSDDEGEDPFAHLPDHEKAVLKRQLDIPTVKVTYFMLFRYATLNDKLLMVLSALSSIIGGALLPLMTIVFGGLTTTFKDFFRQTITQEHFNHELSRFSLYFLYLAIGEFVFVYIATAGFLYTGEHVAGKIRENFLKAILRQNIAFFDQLGAGEITTRITSDTNLVQDGISEKVGLTLTALATFITAFVVSFIKDWKLTLILMSTVFAIVFTMGGMSGFIVKFNKASLASYAEGGTVAEEVISSVRNAKAFNTEAKLTRAYDAHLAVAEKWGFKMKAVTGSMIGFLMCYVYLNYSLAFWMGSRYLVSGRIEVGDVLTIILSIMIGAFALGNVAPNIQAFTTSVAAAAKIFATIDRVSPLDPSSESGETLKSVEGHIELRNIRHIYPSRPEVTVMEDVSLIVPAGKTTALVGESGSGKSTIVGLVERFYDPVGGTVYLDGQDISSLNLRWLRRQISLVSQEPTLFATTIFGNIRHGLIGTAYESESEEKIRELVENAARFANAHDFITGLPEGYATNVGERGFLLSGGQKQRIAIARAMVSDPKILLLDEATSALDTKSEGVVQAALDKAALGRTTIVIAHRLSTIKGADNIVVMSRGRIVEQGTHDALLEKQGAYYNLVEAQRIAAENENKDQEEVAILDEKDQNLKHETTKGEQPEDGLKLARTQTGKSQSSIVLADKKAEVENRYSLWTLIKVVAVFNRQEWLYMTIGIICSVITGGGNPTQAVFFAKAVTALSGDNSTPQGKATIRSQANFWSWMYFMLALVQFSAFLIQGYVFAVCSERLVHRAREQAFKTMLRQDIAFFDKEENTAGALTSFLSTETTHLAGMSGVTLGTILSVIVTLVAAFSVSLAIQWKLSLVCISTVPILLACGFLRFWMLARFQATAKKAYEKSASYACEATSAIRTVASLTREDDVHLHYHDQLVDQERKSLISILRSSSLYAASQSLIFCCTALGFWYGGTLIAKKEIGQFQFFLCFSAVIFGAQSAGTIFSFAPDMGKAKQAAAELKALFDRKPEIDSWSEDGEQLSSVEGHIEFRDVHFRYPTRPEQPVLRGLNLTVKPGQYVALVGASGCGKSTTIQLLERFYDPLAGGVYIDGKEVSSLNVNNYRSWIALVSQEPTLYQGTVKENILLGADRENVPQEAIEQACRDANIYDFIMSLPDAFDTIVGSKGSMLSGGQKQRIAIARALLRDPKILLLDEATSALDSESEKVVQAALDKAAKGRTTIAVAHRLSTIQRADMIYVFDAGKVVESGTHTELIHLRGRYWELVNLQSLGKAQ" }, { "InterPro": [ { "InterPro-ID": "IPR018171", "InterPro-Name": "Pept_tRNA_hydro_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 110, "End": 120 }, { "InterPro-ID": "IPR036416", "InterPro-Name": "Pept_tRNA_hydro_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 3, "End": 192 }, { "InterPro-ID": "IPR001328", "InterPro-Name": "Pept_tRNA_hydro", "InterPro-Type": "FAMILY", "Beg": 3, "End": 182 }, { "InterPro-ID": "IPR036416", "InterPro-Name": "Pept_tRNA_hydro_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1, "End": 194 }, { "InterPro-ID": "IPR018171", "InterPro-Name": "Pept_tRNA_hydro_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 16, "End": 29 }, { "InterPro-ID": "IPR001328", "InterPro-Name": "Pept_tRNA_hydro", "InterPro-Type": "FAMILY", "Beg": 5, "End": 189 }, { "InterPro-ID": "IPR001328", "InterPro-Name": "Pept_tRNA_hydro", "InterPro-Type": "FAMILY", "Beg": 5, "End": 176 }, { "InterPro-ID": "IPR001328", "InterPro-Name": "Pept_tRNA_hydro", "InterPro-Type": "FAMILY", "Beg": 4, "End": 186 }, { "InterPro-ID": "IPR001328", "InterPro-Name": "Pept_tRNA_hydro", "InterPro-Type": "FAMILY", "Beg": 4, "End": 176 } ], "response#1": "MAIKLIVGLANPGAEYAATRHNAGAWYVDLLAERLRAPLREEPKFFGYTSRITLEGEDVRLLVPTTFMNLSGKAVGAMASFYRIQPDEILVAHDELDLPPGVAKFKLGGGHGGHNGLKDIISKLGNNPNFHRLRVGIGHPGDKNKVVGFVLGKPPVSEQKLIDEAIDEAARCTELWFKEGLAKATSRLHTFKAQ", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Pept_tRNA_hydro, Pept_tRNA_hydro, Pept_tRNA_hydro, Pept_tRNA_hydro, Pept_tRNA_hydro that shares evolutionary origin and functional similarity; 2. The protein should be classified within Pept_tRNA_hydro_sf, Pept_tRNA_hydro_sf sharing conserved structural features; 3. The protein should contain Pept_tRNA_hydro_CS, Pept_tRNA_hydro_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MAIKLIVGLANPGAEYAATRHNAGAWYVDLLAERLRAPLREEPKFFGYTSRITLEGEDVRLLVPTTFMNLSGKAVGAMASFYRIQPDEILVAHDELDLPPGVAKFKLGGGHGGHNGLKDIISKLGNNPNFHRLRVGIGHPGDKNKVVGFVLGKPPVSEQKLIDEAIDEAARCTELWFKEGLAKATSRLHTFKAQ" }, { "InterPro": [ { "InterPro-ID": "IPR003599", "InterPro-Name": "Ig_sub", "InterPro-Type": "DOMAIN", "Beg": 164, "End": 256 }, { "InterPro-ID": "IPR032699", "InterPro-Name": "Izumo-Ig", "InterPro-Type": "DOMAIN", "Beg": 166, "End": 257 }, { "InterPro-ID": "IPR013783", "InterPro-Name": "Ig-like_fold", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 157, "End": 257 }, { "InterPro-ID": "IPR032700", "InterPro-Name": "IZUMO1", "InterPro-Type": "FAMILY", "Beg": 3, "End": 335 }, { "InterPro-ID": "IPR007110", "InterPro-Name": "Ig-like_dom", "InterPro-Type": "DOMAIN", "Beg": 158, "End": 247 }, { "InterPro-ID": "IPR029389", "InterPro-Name": "IZUMO", "InterPro-Type": "FAMILY", "Beg": 21, "End": 155 }, { "InterPro-ID": "IPR036179", "InterPro-Name": "Ig-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 166, "End": 260 } ], "response#1": "MTLPILLGWFLTLCSSHIVRSCLQCDQVIRYVHEDFLSTVKGIRVRDQIELKKIIDHAYTNYRETSKLLSGVIDPTTLYRARTEYQSEFKRHWKEDRTNSLQWDLITIVEKGKRILQKHLEIFIAEGLCPNKCGLLYQRVMNCTSCQYGLFTCLSAKPPLDCGEHHLEADEGEEVVLDCFLSWHTLVVGQTEYHYSWHPGETNVLFDGEYEELVVTKESKIVLNQLSVSEEGSYRCLLKDQKGTALSRTFFQLEVKPFPSTSPRQVVTLPSLPLGYENTPYSLQKSSFLTVLILLTVLSITGSLIIIEYLRKSLKRQEEARGRDSRTAGDIELNTE", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Ig_sub, Izumo-Ig, Ig-like_dom that are essential for its biological function; 2. The protein should belong to IZUMO1, IZUMO that shares evolutionary origin and functional similarity; 3. The protein should be classified within Ig-like_fold, Ig-like_dom_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MTLPILLGWFLTLCSSHIVRSCLQCDQVIRYVHEDFLSTVKGIRVRDQIELKKIIDHAYTNYRETSKLLSGVIDPTTLYRARTEYQSEFKRHWKEDRTNSLQWDLITIVEKGKRILQKHLEIFIAEGLCPNKCGLLYQRVMNCTSCQYGLFTCLSAKPPLDCGEHHLEADEGEEVVLDCFLSWHTLVVGQTEYHYSWHPGETNVLFDGEYEELVVTKESKIVLNQLSVSEEGSYRCLLKDQKGTALSRTFFQLEVKPFPSTSPRQVVTLPSLPLGYENTPYSLQKSSFLTVLILLTVLSITGSLIIIEYLRKSLKRQEEARGRDSRTAGDIELNTE" }, { "InterPro": [ { "InterPro-ID": "IPR008775", "InterPro-Name": "Phytyl_CoA_dOase-like", "InterPro-Type": "FAMILY", "Beg": 29, "End": 215 } ], "response#1": "MTLTENVMKPQIQRFTRDHDPKVLWQVVEEDGAVIIEGFLPHEVIQKFDCELDVRSKATKGGEMNQEFYQMPVPTTTKWMNDLTATCPTFRHEILNNDILHSLCNVAFEPHGDYWLLNGMAMEMMPGNPTQQIHNDHGTHPILQYLRPDAPAPVFSIITAVTEFTESNGATRVILGSHRWPQGQKAKDDQAVRAALQPGDALVMHRSTKHGGAAHDADNQDHRRLLLTCMGTCQLAPYETNVTVPRPIVESMTPLAQKMIGWRSTRPVISNVTGLNTVRMKHLENQIELKSNVPLNVGGC", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Phytyl_CoA_dOase-like that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MTLTENVMKPQIQRFTRDHDPKVLWQVVEEDGAVIIEGFLPHEVIQKFDCELDVRSKATKGGEMNQEFYQMPVPTTTKWMNDLTATCPTFRHEILNNDILHSLCNVAFEPHGDYWLLNGMAMEMMPGNPTQQIHNDHGTHPILQYLRPDAPAPVFSIITAVTEFTESNGATRVILGSHRWPQGQKAKDDQAVRAALQPGDALVMHRSTKHGGAAHDADNQDHRRLLLTCMGTCQLAPYETNVTVPRPIVESMTPLAQKMIGWRSTRPVISNVTGLNTVRMKHLENQIELKSNVPLNVGGC" }, { "InterPro": [ { "InterPro-ID": "IPR011641", "InterPro-Name": "Tyr-kin_ephrin_A/B_rcpt-like", "InterPro-Type": "DOMAIN", "Beg": 5468, "End": 5508 }, { "InterPro-ID": "IPR011641", "InterPro-Name": "Tyr-kin_ephrin_A/B_rcpt-like", "InterPro-Type": "DOMAIN", "Beg": 5701, "End": 5739 }, { "InterPro-ID": "IPR011641", "InterPro-Name": "Tyr-kin_ephrin_A/B_rcpt-like", "InterPro-Type": "DOMAIN", "Beg": 5986, "End": 6025 }, { "InterPro-ID": "IPR009030", "InterPro-Name": "Growth_fac_rcpt_cys_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 5405, "End": 5596 }, { "InterPro-ID": "IPR056048", "InterPro-Name": "CRMPA/B-like_DUF7631", "InterPro-Type": "DOMAIN", "Beg": 6315, "End": 6361 }, { "InterPro-ID": "IPR009030", "InterPro-Name": "Growth_fac_rcpt_cys_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 5628, "End": 6034 } ], "response#1": "MTYCRKDKSTIELTAATAAPVSCEGAVTENFRTSRRSKEDPLVHLHSTLHGRSPLRQTCVNMDRVSPFCGTEGCVGSCAGSYCMGYGQCQCDINPHRARGERRTDRHGCTTGVHAHWTGAARRHASSLHPRGHRCQGKRRPCPLSLFPGSCRPCDSFGYPRSSMSSLASDANNSSSAADIVHDFCTKICDPVSVSSFAEVGGSPRSSDASSRPLGKALRKSRLVGFFLVPVFVVFFVLSSDATSSTRGVGVLSARADREEKSSVSSSSRASSSPGASALLVQTTYAENPYRDTKAAGYTGRSSRRSARARRRRAADGGEGKGFLGDMLNKSMLETRSRSTAADPYQQFTSCGSGMFVSTEVGEDGGVEKTAKVDESMNCWNVCAFVEDLVYDQCSSTPSPTECITRALKSHSLVPDGYKGNCRYSSPQDVSPTFWDAEPDSEFCLDKGMNAWLKSDSWDDFVSKKPPGCIYPKQDPSIPASTPTAYVNDATSGLGEALASLVPVEYYVVVRDAEEAMNNPIEYGAYVASSIVPREYWDKVSSDAKDGWHVARAFSVPDKPAEFAALTTAADGSSTSANICLYAAVETANHSDGTSKTFVNYGMIAQTETCEGKIGVLPVADIRGSGILDSSAQEISRKTGFNLCVARRWVTRHLSENGIKSTAQVPMFQVALDAPCASFVSAYAYTDEVPSHWGQWEQYFVAKTYPLTRGIYGIPDAARCPWSYAVQYGLKCYTSIEYDFYMYLGSFAEGQIACRRLVSNIQVPSDFSRLAVMQTDDDEKIMTFLSEPGTFTWVGLFQGSQALVPVKTGFMDSGRVSEQTCPAEVLATGQFSHRNSEIEEKCLQAGANISTPGWKTTWGGLDGNSEIAPWDIKWCSGHPQTERNNRYVDCAGLRVNDNMESCIESAPCDEANPVFCTYPVDYGPYLETTTPQGQSSTGPRLPPYIGCLLRKTCVIQFTLTRPDTSSDTTLPGAHGTIWGVPSEGGFLAVKANCMAVNGPMIGPYRVTSTVNLASLAAFRSARPGLYELCYCNTNSPAVSVVTTGATPDTQCMHQSSFNQLIASLGLTKYNENVGFSQAVQLPTASATVSTKSVLALVGRDSWGGVPTVYCGWQSTGRSCPFDVRVTSNGSWKLRPFTTKLTFYPVDSSVLVTDLCTSEESPAIVVSVTIQSGDTGSAILDAENATSLFYSVCEGKKFLGYVVLKEIGNAVEAKISLENVVLSDQTNVNADDVTLILRGEFTDALLLRSKVVAVSVESATDSDCSTLTLASLPESSVTIVPFPTLSSGTGDLVELHFKAGPSAKKLCWMETIAMGADRDSRTFSTYLVTFPRASTVRELSVEDSRCFGPSDHPCRFRVTPEPVPSEENPINASPYLPSTFRVYVMKDGCPSSAEDSVLDEIDNSSGADPVAANAKGILLELEWESESAMQAVLQPQYFPWLQAIGSANLCWVYTRGNAETECPIGSTSCGDTFGKMYAVGPTSDVQANVVVCLPGAPEPCLTTVEGVNLNLYERITDRMAALDTCGSDTGIGLLTPWGHYAGLIGSSLSALEDGVLRSRSGPSHPSSVSQPSPSFALLGQGLSQTKASFHGSDGRSRGSKSLMWSFATDNDLTDPSSGNTPSNATSLVFQIPFASEGGSLELCFRTGESDSDDLTRFTEPVGHVVYGWRLHGATLAVEATTNPNAVFYRVTVVSGIDAAGALSSTVVYLKPVKGYPEGTTVPCDYDLDTSGDVAHQVQGPVVSSDVDDVTWDDDLGGTSSRGSSASFKIPLLHYQGMAVCWSQLVEASPAQGSHSQSPFSVRSATLVGYFAGPSLPVLAENSDVAVACALAKTTCEIAVGPGRAAVDYTGGLAITPAFLDVRVTVVLDAELLAAPCPDPSDPGYENAIRATSQTRLVLPSDVLTPERQTFLVDSNARELLKTNGKAGICYRVDNCATESDAPTSDCTKFLGLALWVGPTAETPDKVTICKAQQRDCLLRIDGSNMDVVDYSAPRAAYAATCGEPGQYVTATLVQTSSTPSQETLDSDLVSNEHASWAAFAFAIQPASLWRLCWNPFDAATMQDEPAEDRFVVNRGFLVFPATPEVESERVELDSSSQTMLRLVISAMVTEAALEKVSRPDTPVTEHYVYVSPVLSHANGVAEDVVCADADEETKVQWTSVDAKTPTAFGNEDSNDAATASRIHYSITAISVEQQVCWRSVYRAEDGTVVHEERIYLSKVPAVLTPELDTSVANQVSPLLTFCSLGTEEMCLVTLKPRASSDSTPATFPPGGELYVVHEGDCPSERADPKLVNAAGDGVPTTDTTVVRLHVVTFDTTRVALGFPEDDRTWMSARKAAALCFVFGENQCPASGACVERIGMIYWRGPRVFEDTQLRVLCNDPQGCDISVTGLNLNTYDLSYSRVAALDSCGEPGGLGRLDIVRYPAGYTQDSPVEPLDDYFTSDDSFGQGSFAINNMGRGVLTCGASEAVSVTTASWGPADLQNSKVACDPVDVLEHVAAHCEGKAICVVYPHTPRDDETVRSYIGLKQEEFLRLSDPCPGTANEDLRLVGTHTCVAGTRSVTPEVAMVETTSRVAAGGANYSNPSTDAMDMVVKLPPDIAKVYELCWNPDPVITLQPARYNVKVGVAQIVPVAGLVDLISTVFERIDDANVEVVLRGILAEEVAVNTSIYLKQIPDEGAISCSNDDQENAIGKATFMSYESGDAGTTVIRYRIAAVDSEKAVCWRWTSQDFAAGGGGVQSILIGTLPGTVNPVSRAWGEMMCSLPGGTDCSIEFEPDSLLGTYPTEEEPGSGAVTGFTDYAQFANLHSHLRKGTKIGLIAGRESCPEDPQDLAYQRFTQTGIAEGDISDSEVQETTIGLPISGGKPSSLVSTMSVGLLHWLAVHKDAIVCWVNADECKTTKTPRFATCTATVGTLSWKGPIPTEWSVTAVDLVCRTGGRCRLKIPGRNMFKLDLSESPVAIVRTCGGDEGPGIAKLQQTPVLYPSQQADDGVQSGSLLQTTMSLSSNQRRAVRQLRRSCKMGSEDHADRCDTRLATGNTAMGFAAGSRRHPSFMEVLLGSRKAPSSSVDDSIEVVTTIKTGGEYAICWNPSALSTNLSDFTVNIGRVFSYGLEQIDALCYSGSYCELNFTYIGSSNPTLFVGVKAVDCSDPDLTTELGSGGVFKTTGRNTLSLSEPIPRRPQSSRVSYKLCWCDMNEVQECVGTSYSAPVGTLTVQFIEEKAVACQEAVGACSISFDASDFQGDSSGTIFLTQYSGTNADCMQPKKYVPHVSAIFGNIVVQVDQATLAATLGQHAAEQGSFAICRQMTAAIDEYTGSSNAVPEADENQVESAEPEQNAEGETPEQGAEEAGGNAAEPGAESGTQEGAVTPGVEPDGGEPVAPEVDSGGGESVAPGVDSGGGDSVAPGVDSGGGDSVAPGVDSGSGVAGTASEGVDEQSDLTTSQPEDLEAKSQTALGMVQLDDTGSDTSLQVTSSPALLGVLQFAGPASTEYQDETQVAVLGMATRIAVVTQGFDRFIDTDITADSSDIPTGVAHVRLVPAGGCGHDNGSNSVVLSLSQVIQKESDLPEKAIYSQEEILQINTGAIRKLDVCWCDLGTACKKDTDFTIPVLSVGLVAPEQDLVVKCPCGSKCPFEFQGVSEAPQHGVEPDYFVKNDGCSGAPAELPDQGHLVTVVSSVIAAEHSDDAVADVDRSPAGELETLNKQIQAFRAEVDRTSVFATGTTEGSREYAICYCAFRTGGCANDALIRIGTLTVYDVWRDKMSAVVADDVTIRPPSPPFSGIQGTLYAQAGAVTLPVSTLPDKAYQIDLSTLEGRRTPASVVDVRYCESEVTQSCDDEGAPRIDLTQIELKGPVSLSFEDECRLGFRCTIVTEVFNPTEEEKLAALASCGSSSEHDYGLSSGVRTAEDNPAKAVEVTFEWEKTLPDVGRSELDFCWCKKTNQVDCSAVDQYTLKVGTLYITGLAAGQEATCHVGSVCVAHLKGYRLVEEVVNVRVVAGECGTAGSEISGLPNGGIFVPEQVAESSAEVSLIEPFFGLAVETAAICQCPMPTQACESEADYAWEAGRYIFSGPSERVVINALSGQGVEVEIPWRGEQDTASDFFILTRDTMCSGTTSGLIDGVVDNGLGHLEDGEVAWEEFAYHGGIYSVCYCRRSTPLATGSANPFSGGSASASQHLCGTVAEYRVSVALVLLSGPVTSNAIFSCFGGLACHVDISVAGVDSLESQEFLDSAALQVSTESCGADVIMEAMLSDSEESSDTLDDSSSDAQMKTFNQRFGFPNVVTVSAGYYVACWKPATSSPALLLGDFVVKGPVADKTPLESSSGEDIDVAVTYVGLESSDEAKAMRIQIAPIPEGRENDAFDCASLNLSEAQPYLRYTNLNRAPDTVESVSVQFSRIVWKAVSILIDNQSPNVLPGSYFAICFCNGNRGDCSVSENYFFQTNKWAVGGLSQRTLDEPLPVGRTITLTLPGKRLPLHNHLMLLPSLDRSTFAERHCGDAGGAGDGRIISATRLAHVTDWVGFKEVTITSASRTILMCWCGGDNCQTGDKFRTFVGSLSVEFPKFEATSAVIGGTFTVTLRGSVLRAQDAITVVDQSKQCGEEGTDEMDASAVEVPVGLEVTDLIQLRQARVVHADSTADSTSLSVADTSTPLVWQSWPIKTKPSVSGRLRVCYCSSEGGVCTGASRFSVWVGNVQVKGPSTGEVEIVTVDGEAKVETSGVSLALTDKLRIFAKSLAASDTVRDRRELCESGITAESTTVVADYVSPDGRTETFPVDLEPGFRYVLCWSGGTGASTQSARANPAVTRAAPTVNLPSLYRANSGSNASTVQLAEEATAALNMLQQAASTGSATSALAPHAETETPTETWSYLDAITPTGFSTGLEFRLVQNFESEVLYIPGSPNVSHSYVAYVGQKDLQADCEEIKQNPLITMETMIHIQDDSVSFSVGRISEAGLYPVCVCDSTANECYDVGTAHVDKTYWKTVAELVYDNRFFMLPCVTRGIQASAADGQSWSEDRVWLPDGMGAWSFVLTTTDSDSKPAPVLKRTPATGSKAATWVNFYEKGLRSTVACATGSGQRIFFLGPGVVYMMDPVPGLTPDLSTATGQMFTHSVLKPVDFSVREPYIFFSDYETQVITSINIENPSLTHAFFPTDPVMLFSAGVNVMDTDENFMALCVADTFNHIVGRLNISFDTMNKPQSQVTGTPWTAYFGTPKTAQNGINGFSYPFALTSYSPQSTSEAELMSLLLVTELVSDRLVFLDLSNNGLTFYKQISLSERHLISGLQSVDKTVMLISRAWPPTSKSGGMDAYVSLLNLEDVGGDLYFTYPDFRSKLQSGLFYSFEPLITGSVIQSFKEVSGSDLAKMGLTLNSATGVISGTVSHTGPFTIAVAGGDLLETFTWTISGEAGCRSGEYFDSTNNACELCPVGTFRDQEANLQKCHDIKPYSTTLSPGSTHLAQCRCFPGFEIGNLGDCHPCGAGTYKSSISDTKCTGRCPGNMHSYIQGAENEEDLLCMCDAGYYEDGGGCTPCQQGYYCPGEHSPPEPCPENHTTKGGASKSISDCVCVAGYTKQGDACVECDRLSYKGTTGNDACTGCPQPAAKGDRDALIASTKLDEAQFTTKPGAKKVSDCMLCASGFFYDVSNGGCTPCRKNYYCPGTDQEPRACVENATTLRGGAESTFDCKCPKGYGGSVARNPLDKAIVCVACPKNTFQHLDGVMTDCLPCPPFTMTKSTKSASFSACVARPGFYLSSRLSDMSRSLAESRSDDGTVGDDVDLDDNALSGTTNSGWTTSSSNSERVRKAEVQYENMSDEELLDLPRLCQRGTGLIDILLPEVKMQKYTNSFEQCIIACARNVYCTSLTFTNEGNAVPAMTASVTNHTGTFIIGYWICELHMYGPPVDQETVASITDPITETVVPASWTVSCAMQRPESDTVWRSVTYEECPVNAYCPGDEEAQIYQCPASSVTLANRASAAEHCKCIPGYHLSGRQCEPCRVGTYKNTTDNTNCAECPTGFTTENLASISAYDCACIPGLYMIANADADAEGEADHTPADGSSNSSEDSIVTHPKPDADSSDSQAPAEQTEGHAGNTNQQVDAADGETPDTTHEEASEAESVSAVELRGGLLVRGDGGVLQRAFKASQNSASKRSSRALGDAIGEEQGLSFYQTTAAPWLQPDIRQELEKIVTLHPCVSCYKHMYCPGLWMDPPVNQIHMPPQHCPEGSTVPLSTALSDSVEKCLCMAGYAVVEGSTGGTHEDNAYFGCEKCAAGTYKELQENAPCAGRCMRDAETIEGAVAKIQCFCKIGKYAVVAEDAEGIITCQDCIAGGVCPGGLKTRARQAVEQDHSFVKITIDDHQVPFPSSGFYAVYKPLNETVWSPAMVPMVASFTGDTFKEFTDTGPAPDDHTDEGGANLDSTGGSGEPSSSAPVDPSGENEGQLLTGTTGAVSALQMRSRANDTSVHQYDRIPDIHPCVDDVRCRGGSHNSCVHGSAGYLCSACEEDYSEIRYKSGCQACLPLWLDSFIFILMRLVVCGIIWIITALTIIAVQQQACIHPVLIRIVMSHMFFLSVYGLMPATSQSQLAGWASIYRLFFFEFYFALHPYFKMPCFFRSLGIVMPEAHVWYWQHFFQIFVPFIDAVLLTIIGAICVATYKVMYSAYISRVLVVLEEARQAHGDDMWTEKTIRKIESERCLGMFRYIYGTSTPWENFVRLCTDLIPAYTAIWFWHFPTFVIECTMLMGCIETRYKSEDPISVLAAFPVQICSFENPYFLSGLILGGVGLLVWGVGSIAGFVAYMSGDHSSDTIEQRFKHGFLVNGYQYAYRWWEGVIGLRKTCVALIITMYVHANASGAQEIFRNSANLALTVLSTALQLQLEPFDKRSHDMANRMEFYGLMVNIIIGVIFQGSYYFEVFKYMGAIPLAVAIFYYLYVLWSLFVEWGRMVMMRPHLVSIPSLWRYYNRVTRSLARLYTSRNAKIYYNYITKDMVLEAATKSRVFHLRRLLLRRKKTSYRKINYENRTYFVAALSDSLSQLVIAWCQFTIPGDWLDFTIRYAFCYCFWQRYQDNRSLRVPLDLEEFEAVKPTLFSDWYYDSEKNDPQGEGDIDFGTEILEGGEITFNTAEQDFLDLMLDDDVYDDSPITLMELYVAVQSMQHVPQRQLRRLHLAYRERMTQAGDSTAPQLRKENHALEGELEELNRALLEMAGADENMPDLTFSPLDFFFTVEMVNQAQLEVERLRGLIESEIDDIARARAAQAVAVHLELSMNEAADVDKLLEAMETDERTTKEEEMTRIGYVEESTSRMEKKAGLAGRRARLAFADKRPPVNLDDKRRIKLGLAAGVGGAQRRRIGLVTRGAEGPPGAKRRIGRHEVEFHRTVQGLAAGAAPAAGLRSHMGTSSSLGDQLGDDRRTVRLGTNLSTPSAVGNKRTLRRDTSGASAELIVDTAPKAPAATRTLSPLLDREPPVVESEGSVGERRESPTPSRSPSGTTRTVGSVVRSVTPEPSDSVGREESGSEAPLISPSASSLASPRSLSPLTERRGSQSSDLGGRRRLGPLTGPRPPPPVGEAAPAEAPSPSPRSSSPLAAQPKGQGLPLGKRQLKKPGSPKQE", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Tyr-kin_ephrin_A/B_rcpt-like, Tyr-kin_ephrin_A/B_rcpt-like, Tyr-kin_ephrin_A/B_rcpt-like, CRMPA/B-like_DUF7631 that are essential for its biological function; 2. The protein should be classified within Growth_fac_rcpt_cys_sf, Growth_fac_rcpt_cys_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MTYCRKDKSTIELTAATAAPVSCEGAVTENFRTSRRSKEDPLVHLHSTLHGRSPLRQTCVNMDRVSPFCGTEGCVGSCAGSYCMGYGQCQCDINPHRARGERRTDRHGCTTGVHAHWTGAARRHASSLHPRGHRCQGKRRPCPLSLFPGSCRPCDSFGYPRSSMSSLASDANNSSSAADIVHDFCTKICDPVSVSSFAEVGGSPRSSDASSRPLGKALRKSRLVGFFLVPVFVVFFVLSSDATSSTRGVGVLSARADREEKSSVSSSSRASSSPGASALLVQTTYAENPYRDTKAAGYTGRSSRRSARARRRRAADGGEGKGFLGDMLNKSMLETRSRSTAADPYQQFTSCGSGMFVSTEVGEDGGVEKTAKVDESMNCWNVCAFVEDLVYDQCSSTPSPTECITRALKSHSLVPDGYKGNCRYSSPQDVSPTFWDAEPDSEFCLDKGMNAWLKSDSWDDFVSKKPPGCIYPKQDPSIPASTPTAYVNDATSGLGEALASLVPVEYYVVVRDAEEAMNNPIEYGAYVASSIVPREYWDKVSSDAKDGWHVARAFSVPDKPAEFAALTTAADGSSTSANICLYAAVETANHSDGTSKTFVNYGMIAQTETCEGKIGVLPVADIRGSGILDSSAQEISRKTGFNLCVARRWVTRHLSENGIKSTAQVPMFQVALDAPCASFVSAYAYTDEVPSHWGQWEQYFVAKTYPLTRGIYGIPDAARCPWSYAVQYGLKCYTSIEYDFYMYLGSFAEGQIACRRLVSNIQVPSDFSRLAVMQTDDDEKIMTFLSEPGTFTWVGLFQGSQALVPVKTGFMDSGRVSEQTCPAEVLATGQFSHRNSEIEEKCLQAGANISTPGWKTTWGGLDGNSEIAPWDIKWCSGHPQTERNNRYVDCAGLRVNDNMESCIESAPCDEANPVFCTYPVDYGPYLETTTPQGQSSTGPRLPPYIGCLLRKTCVIQFTLTRPDTSSDTTLPGAHGTIWGVPSEGGFLAVKANCMAVNGPMIGPYRVTSTVNLASLAAFRSARPGLYELCYCNTNSPAVSVVTTGATPDTQCMHQSSFNQLIASLGLTKYNENVGFSQAVQLPTASATVSTKSVLALVGRDSWGGVPTVYCGWQSTGRSCPFDVRVTSNGSWKLRPFTTKLTFYPVDSSVLVTDLCTSEESPAIVVSVTIQSGDTGSAILDAENATSLFYSVCEGKKFLGYVVLKEIGNAVEAKISLENVVLSDQTNVNADDVTLILRGEFTDALLLRSKVVAVSVESATDSDCSTLTLASLPESSVTIVPFPTLSSGTGDLVELHFKAGPSAKKLCWMETIAMGADRDSRTFSTYLVTFPRASTVRELSVEDSRCFGPSDHPCRFRVTPEPVPSEENPINASPYLPSTFRVYVMKDGCPSSAEDSVLDEIDNSSGADPVAANAKGILLELEWESESAMQAVLQPQYFPWLQAIGSANLCWVYTRGNAETECPIGSTSCGDTFGKMYAVGPTSDVQANVVVCLPGAPEPCLTTVEGVNLNLYERITDRMAALDTCGSDTGIGLLTPWGHYAGLIGSSLSALEDGVLRSRSGPSHPSSVSQPSPSFALLGQGLSQTKASFHGSDGRSRGSKSLMWSFATDNDLTDPSSGNTPSNATSLVFQIPFASEGGSLELCFRTGESDSDDLTRFTEPVGHVVYGWRLHGATLAVEATTNPNAVFYRVTVVSGIDAAGALSSTVVYLKPVKGYPEGTTVPCDYDLDTSGDVAHQVQGPVVSSDVDDVTWDDDLGGTSSRGSSASFKIPLLHYQGMAVCWSQLVEASPAQGSHSQSPFSVRSATLVGYFAGPSLPVLAENSDVAVACALAKTTCEIAVGPGRAAVDYTGGLAITPAFLDVRVTVVLDAELLAAPCPDPSDPGYENAIRATSQTRLVLPSDVLTPERQTFLVDSNARELLKTNGKAGICYRVDNCATESDAPTSDCTKFLGLALWVGPTAETPDKVTICKAQQRDCLLRIDGSNMDVVDYSAPRAAYAATCGEPGQYVTATLVQTSSTPSQETLDSDLVSNEHASWAAFAFAIQPASLWRLCWNPFDAATMQDEPAEDRFVVNRGFLVFPATPEVESERVELDSSSQTMLRLVISAMVTEAALEKVSRPDTPVTEHYVYVSPVLSHANGVAEDVVCADADEETKVQWTSVDAKTPTAFGNEDSNDAATASRIHYSITAISVEQQVCWRSVYRAEDGTVVHEERIYLSKVPAVLTPELDTSVANQVSPLLTFCSLGTEEMCLVTLKPRASSDSTPATFPPGGELYVVHEGDCPSERADPKLVNAAGDGVPTTDTTVVRLHVVTFDTTRVALGFPEDDRTWMSARKAAALCFVFGENQCPASGACVERIGMIYWRGPRVFEDTQLRVLCNDPQGCDISVTGLNLNTYDLSYSRVAALDSCGEPGGLGRLDIVRYPAGYTQDSPVEPLDDYFTSDDSFGQGSFAINNMGRGVLTCGASEAVSVTTASWGPADLQNSKVACDPVDVLEHVAAHCEGKAICVVYPHTPRDDETVRSYIGLKQEEFLRLSDPCPGTANEDLRLVGTHTCVAGTRSVTPEVAMVETTSRVAAGGANYSNPSTDAMDMVVKLPPDIAKVYELCWNPDPVITLQPARYNVKVGVAQIVPVAGLVDLISTVFERIDDANVEVVLRGILAEEVAVNTSIYLKQIPDEGAISCSNDDQENAIGKATFMSYESGDAGTTVIRYRIAAVDSEKAVCWRWTSQDFAAGGGGVQSILIGTLPGTVNPVSRAWGEMMCSLPGGTDCSIEFEPDSLLGTYPTEEEPGSGAVTGFTDYAQFANLHSHLRKGTKIGLIAGRESCPEDPQDLAYQRFTQTGIAEGDISDSEVQETTIGLPISGGKPSSLVSTMSVGLLHWLAVHKDAIVCWVNADECKTTKTPRFATCTATVGTLSWKGPIPTEWSVTAVDLVCRTGGRCRLKIPGRNMFKLDLSESPVAIVRTCGGDEGPGIAKLQQTPVLYPSQQADDGVQSGSLLQTTMSLSSNQRRAVRQLRRSCKMGSEDHADRCDTRLATGNTAMGFAAGSRRHPSFMEVLLGSRKAPSSSVDDSIEVVTTIKTGGEYAICWNPSALSTNLSDFTVNIGRVFSYGLEQIDALCYSGSYCELNFTYIGSSNPTLFVGVKAVDCSDPDLTTELGSGGVFKTTGRNTLSLSEPIPRRPQSSRVSYKLCWCDMNEVQECVGTSYSAPVGTLTVQFIEEKAVACQEAVGACSISFDASDFQGDSSGTIFLTQYSGTNADCMQPKKYVPHVSAIFGNIVVQVDQATLAATLGQHAAEQGSFAICRQMTAAIDEYTGSSNAVPEADENQVESAEPEQNAEGETPEQGAEEAGGNAAEPGAESGTQEGAVTPGVEPDGGEPVAPEVDSGGGESVAPGVDSGGGDSVAPGVDSGGGDSVAPGVDSGSGVAGTASEGVDEQSDLTTSQPEDLEAKSQTALGMVQLDDTGSDTSLQVTSSPALLGVLQFAGPASTEYQDETQVAVLGMATRIAVVTQGFDRFIDTDITADSSDIPTGVAHVRLVPAGGCGHDNGSNSVVLSLSQVIQKESDLPEKAIYSQEEILQINTGAIRKLDVCWCDLGTACKKDTDFTIPVLSVGLVAPEQDLVVKCPCGSKCPFEFQGVSEAPQHGVEPDYFVKNDGCSGAPAELPDQGHLVTVVSSVIAAEHSDDAVADVDRSPAGELETLNKQIQAFRAEVDRTSVFATGTTEGSREYAICYCAFRTGGCANDALIRIGTLTVYDVWRDKMSAVVADDVTIRPPSPPFSGIQGTLYAQAGAVTLPVSTLPDKAYQIDLSTLEGRRTPASVVDVRYCESEVTQSCDDEGAPRIDLTQIELKGPVSLSFEDECRLGFRCTIVTEVFNPTEEEKLAALASCGSSSEHDYGLSSGVRTAEDNPAKAVEVTFEWEKTLPDVGRSELDFCWCKKTNQVDCSAVDQYTLKVGTLYITGLAAGQEATCHVGSVCVAHLKGYRLVEEVVNVRVVAGECGTAGSEISGLPNGGIFVPEQVAESSAEVSLIEPFFGLAVETAAICQCPMPTQACESEADYAWEAGRYIFSGPSERVVINALSGQGVEVEIPWRGEQDTASDFFILTRDTMCSGTTSGLIDGVVDNGLGHLEDGEVAWEEFAYHGGIYSVCYCRRSTPLATGSANPFSGGSASASQHLCGTVAEYRVSVALVLLSGPVTSNAIFSCFGGLACHVDISVAGVDSLESQEFLDSAALQVSTESCGADVIMEAMLSDSEESSDTLDDSSSDAQMKTFNQRFGFPNVVTVSAGYYVACWKPATSSPALLLGDFVVKGPVADKTPLESSSGEDIDVAVTYVGLESSDEAKAMRIQIAPIPEGRENDAFDCASLNLSEAQPYLRYTNLNRAPDTVESVSVQFSRIVWKAVSILIDNQSPNVLPGSYFAICFCNGNRGDCSVSENYFFQTNKWAVGGLSQRTLDEPLPVGRTITLTLPGKRLPLHNHLMLLPSLDRSTFAERHCGDAGGAGDGRIISATRLAHVTDWVGFKEVTITSASRTILMCWCGGDNCQTGDKFRTFVGSLSVEFPKFEATSAVIGGTFTVTLRGSVLRAQDAITVVDQSKQCGEEGTDEMDASAVEVPVGLEVTDLIQLRQARVVHADSTADSTSLSVADTSTPLVWQSWPIKTKPSVSGRLRVCYCSSEGGVCTGASRFSVWVGNVQVKGPSTGEVEIVTVDGEAKVETSGVSLALTDKLRIFAKSLAASDTVRDRRELCESGITAESTTVVADYVSPDGRTETFPVDLEPGFRYVLCWSGGTGASTQSARANPAVTRAAPTVNLPSLYRANSGSNASTVQLAEEATAALNMLQQAASTGSATSALAPHAETETPTETWSYLDAITPTGFSTGLEFRLVQNFESEVLYIPGSPNVSHSYVAYVGQKDLQADCEEIKQNPLITMETMIHIQDDSVSFSVGRISEAGLYPVCVCDSTANECYDVGTAHVDKTYWKTVAELVYDNRFFMLPCVTRGIQASAADGQSWSEDRVWLPDGMGAWSFVLTTTDSDSKPAPVLKRTPATGSKAATWVNFYEKGLRSTVACATGSGQRIFFLGPGVVYMMDPVPGLTPDLSTATGQMFTHSVLKPVDFSVREPYIFFSDYETQVITSINIENPSLTHAFFPTDPVMLFSAGVNVMDTDENFMALCVADTFNHIVGRLNISFDTMNKPQSQVTGTPWTAYFGTPKTAQNGINGFSYPFALTSYSPQSTSEAELMSLLLVTELVSDRLVFLDLSNNGLTFYKQISLSERHLISGLQSVDKTVMLISRAWPPTSKSGGMDAYVSLLNLEDVGGDLYFTYPDFRSKLQSGLFYSFEPLITGSVIQSFKEVSGSDLAKMGLTLNSATGVISGTVSHTGPFTIAVAGGDLLETFTWTISGEAGCRSGEYFDSTNNACELCPVGTFRDQEANLQKCHDIKPYSTTLSPGSTHLAQCRCFPGFEIGNLGDCHPCGAGTYKSSISDTKCTGRCPGNMHSYIQGAENEEDLLCMCDAGYYEDGGGCTPCQQGYYCPGEHSPPEPCPENHTTKGGASKSISDCVCVAGYTKQGDACVECDRLSYKGTTGNDACTGCPQPAAKGDRDALIASTKLDEAQFTTKPGAKKVSDCMLCASGFFYDVSNGGCTPCRKNYYCPGTDQEPRACVENATTLRGGAESTFDCKCPKGYGGSVARNPLDKAIVCVACPKNTFQHLDGVMTDCLPCPPFTMTKSTKSASFSACVARPGFYLSSRLSDMSRSLAESRSDDGTVGDDVDLDDNALSGTTNSGWTTSSSNSERVRKAEVQYENMSDEELLDLPRLCQRGTGLIDILLPEVKMQKYTNSFEQCIIACARNVYCTSLTFTNEGNAVPAMTASVTNHTGTFIIGYWICELHMYGPPVDQETVASITDPITETVVPASWTVSCAMQRPESDTVWRSVTYEECPVNAYCPGDEEAQIYQCPASSVTLANRASAAEHCKCIPGYHLSGRQCEPCRVGTYKNTTDNTNCAECPTGFTTENLASISAYDCACIPGLYMIANADADAEGEADHTPADGSSNSSEDSIVTHPKPDADSSDSQAPAEQTEGHAGNTNQQVDAADGETPDTTHEEASEAESVSAVELRGGLLVRGDGGVLQRAFKASQNSASKRSSRALGDAIGEEQGLSFYQTTAAPWLQPDIRQELEKIVTLHPCVSCYKHMYCPGLWMDPPVNQIHMPPQHCPEGSTVPLSTALSDSVEKCLCMAGYAVVEGSTGGTHEDNAYFGCEKCAAGTYKELQENAPCAGRCMRDAETIEGAVAKIQCFCKIGKYAVVAEDAEGIITCQDCIAGGVCPGGLKTRARQAVEQDHSFVKITIDDHQVPFPSSGFYAVYKPLNETVWSPAMVPMVASFTGDTFKEFTDTGPAPDDHTDEGGANLDSTGGSGEPSSSAPVDPSGENEGQLLTGTTGAVSALQMRSRANDTSVHQYDRIPDIHPCVDDVRCRGGSHNSCVHGSAGYLCSACEEDYSEIRYKSGCQACLPLWLDSFIFILMRLVVCGIIWIITALTIIAVQQQACIHPVLIRIVMSHMFFLSVYGLMPATSQSQLAGWASIYRLFFFEFYFALHPYFKMPCFFRSLGIVMPEAHVWYWQHFFQIFVPFIDAVLLTIIGAICVATYKVMYSAYISRVLVVLEEARQAHGDDMWTEKTIRKIESERCLGMFRYIYGTSTPWENFVRLCTDLIPAYTAIWFWHFPTFVIECTMLMGCIETRYKSEDPISVLAAFPVQICSFENPYFLSGLILGGVGLLVWGVGSIAGFVAYMSGDHSSDTIEQRFKHGFLVNGYQYAYRWWEGVIGLRKTCVALIITMYVHANASGAQEIFRNSANLALTVLSTALQLQLEPFDKRSHDMANRMEFYGLMVNIIIGVIFQGSYYFEVFKYMGAIPLAVAIFYYLYVLWSLFVEWGRMVMMRPHLVSIPSLWRYYNRVTRSLARLYTSRNAKIYYNYITKDMVLEAATKSRVFHLRRLLLRRKKTSYRKINYENRTYFVAALSDSLSQLVIAWCQFTIPGDWLDFTIRYAFCYCFWQRYQDNRSLRVPLDLEEFEAVKPTLFSDWYYDSEKNDPQGEGDIDFGTEILEGGEITFNTAEQDFLDLMLDDDVYDDSPITLMELYVAVQSMQHVPQRQLRRLHLAYRERMTQAGDSTAPQLRKENHALEGELEELNRALLEMAGADENMPDLTFSPLDFFFTVEMVNQAQLEVERLRGLIESEIDDIARARAAQAVAVHLELSMNEAADVDKLLEAMETDERTTKEEEMTRIGYVEESTSRMEKKAGLAGRRARLAFADKRPPVNLDDKRRIKLGLAAGVGGAQRRRIGLVTRGAEGPPGAKRRIGRHEVEFHRTVQGLAAGAAPAAGLRSHMGTSSSLGDQLGDDRRTVRLGTNLSTPSAVGNKRTLRRDTSGASAELIVDTAPKAPAATRTLSPLLDREPPVVESEGSVGERRESPTPSRSPSGTTRTVGSVVRSVTPEPSDSVGREESGSEAPLISPSASSLASPRSLSPLTERRGSQSSDLGGRRRLGPLTGPRPPPPVGEAAPAEAPSPSPRSSSPLAAQPKGQGLPLGKRQLKKPGSPKQE" }, { "InterPro": [ { "InterPro-ID": "IPR035892", "InterPro-Name": "C2_domain_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1194, "End": 1318 }, { "InterPro-ID": "IPR000008", "InterPro-Name": "C2_dom", "InterPro-Type": "DOMAIN", "Beg": 1031, "End": 1154 }, { "InterPro-ID": "IPR037721", "InterPro-Name": "Ferlin", "InterPro-Type": "FAMILY", "Beg": 360, "End": 1159 }, { "InterPro-ID": "IPR000008", "InterPro-Name": "C2_dom", "InterPro-Type": "DOMAIN", "Beg": 512, "End": 638 }, { "InterPro-ID": "IPR000008", "InterPro-Name": "C2_dom", "InterPro-Type": "DOMAIN", "Beg": 161, "End": 279 }, { "InterPro-ID": "IPR000008", "InterPro-Name": "C2_dom", "InterPro-Type": "DOMAIN", "Beg": 1, "End": 111 }, { "InterPro-ID": "IPR035892", "InterPro-Name": "C2_domain_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1043, "End": 1181 }, { "InterPro-ID": "IPR035892", "InterPro-Name": "C2_domain_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 178, "End": 288 }, { "InterPro-ID": "IPR035892", "InterPro-Name": "C2_domain_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 161, "End": 296 }, { "InterPro-ID": "IPR035892", "InterPro-Name": "C2_domain_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1179, "End": 1309 }, { "InterPro-ID": "IPR035892", "InterPro-Name": "C2_domain_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1049, "End": 1193 }, { "InterPro-ID": "IPR000008", "InterPro-Name": "C2_dom", "InterPro-Type": "DOMAIN", "Beg": 1050, "End": 1153 }, { "InterPro-ID": "IPR000008", "InterPro-Name": "C2_dom", "InterPro-Type": "DOMAIN", "Beg": 8, "End": 110 }, { "InterPro-ID": "IPR000008", "InterPro-Name": "C2_dom", "InterPro-Type": "DOMAIN", "Beg": 181, "End": 278 }, { "InterPro-ID": "IPR000008", "InterPro-Name": "C2_dom", "InterPro-Type": "DOMAIN", "Beg": 533, "End": 636 }, { "InterPro-ID": "IPR000008", "InterPro-Name": "C2_dom", "InterPro-Type": "DOMAIN", "Beg": 1207, "End": 1317 }, { "InterPro-ID": "IPR037725", "InterPro-Name": "C2F_Ferlin", "InterPro-Type": "DOMAIN", "Beg": 1207, "End": 1362 }, { "InterPro-ID": "IPR000008", "InterPro-Name": "C2_dom", "InterPro-Type": "DOMAIN", "Beg": 533, "End": 626 }, { "InterPro-ID": "IPR000008", "InterPro-Name": "C2_dom", "InterPro-Type": "DOMAIN", "Beg": 182, "End": 281 }, { "InterPro-ID": "IPR000008", "InterPro-Name": "C2_dom", "InterPro-Type": "DOMAIN", "Beg": 1208, "End": 1307 }, { "InterPro-ID": "IPR000008", "InterPro-Name": "C2_dom", "InterPro-Type": "DOMAIN", "Beg": 1050, "End": 1146 }, { "InterPro-ID": "IPR000008", "InterPro-Name": "C2_dom", "InterPro-Type": "DOMAIN", "Beg": 11, "End": 104 }, { "InterPro-ID": "IPR000008", "InterPro-Name": "C2_dom", "InterPro-Type": "DOMAIN", "Beg": 1189, "End": 1318 }, { "InterPro-ID": "IPR035892", "InterPro-Name": "C2_domain_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 6, "End": 130 }, { "InterPro-ID": "IPR035892", "InterPro-Name": "C2_domain_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 7, "End": 133 }, { "InterPro-ID": "IPR035892", "InterPro-Name": "C2_domain_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 532, "End": 666 }, { "InterPro-ID": "IPR035892", "InterPro-Name": "C2_domain_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 518, "End": 667 } ], "response#1": "MGKTKIYSVGFTVHEAQTLVTEKGQPVDPLVVVRCCGREYRTEIKYAKSNVVSWDESHTWTDLCLTDEEWETAYITFEVQAANAFWRNTLLGLVSVQLRLIQLRKTHQIRKALPLQHPDDTDVHGSLRVTVFACAPGEAPPSPGEEEVLEEEDHNDYDDLRKAVIDTNQVVEREAGSRLYHVYVTAYRVEDLPRSSKGARDPFVTCEFAGCKLKSTQARGCCSHTFNECFRFPVVTPLPEDAILIKIWDWNFMKADELIAVGRISFSELRTRQMVPRWFNLYGFDDEEVAQATKVAGQGGRLVANCYLGRILLGARAERLTKEDDLMPAHTVAARPYETPPVIPLAVLADVYEVQGAPGEKVSVEIWCGPARARTKWVTGLETKAAQRAGVAPQAFNRAMEGALGVASYLRGDIPEGEDRFPFDNTEGRVEDLRLVVPEDTKQQWDIIISLYVRGTTKGFMGDTRIAFQRLKMSKIPGHVHNNPRAPIWVPLISTPPFESVKPAPAILMVIEKSKVEAFARSKRKHVTAVGYQLRAYVYAARNLLSPSGALPNPFVQVACAGTSRETEVFEQTSSPVFMDCLLLDITMMTDPVSRLPTVAPIVVTLFEQRSWGIQFLGRATCHYDRLRGRLKPGESPTVAEPRWIKLRGGKYANRHLGDVLLLLELIRKRDAEIIPAFPMRPVVNMCNLTFSCLGVRSLYMTQRAKRLDYVSIRKGQDKKTELRRIRGPLLRISVSSYASAGRGNNEAILRYERNLPEDPTTVNKLWTTVTKAANADIFKVVNMEIDVPVDPIYDPRLVVQVYDRKQKPKYFIGEYSMSLVPLIPWVLDQQSAIEAVSPVNDFTDTVDLKHLGGLLRGFHGNSKNRGTGQIGLEALSAADRETADAHKEKTLAQSRFATYDPDNKTFSDSWLLPSGLPKILVSSYAVPGFRCDVIYTNMFTLNVYIPAKFVLFAEGKRAADKKTKEQYARPSVDSTLEQFLDDVIFPSDSLKKSVMGDIDVTGFVKFFVNLTHHEEPNPHVDSSAAEWASSEDRMRRHLRGEDAYPKLLKIRVYVIRAISLYVGDDRILPNPYLLFNLGDKSDTLRAEAKPNTHNPEFFTVWEKDVMFPDDSQFELQVWSAHEGTSGGLDDIFIGSTCIDLEERWFSKEWQKSMSKNQVPMEYRPLKQMPSGSFKGTVEMWVELMDFQKAGEVPKFDLQSPAATEVEIRVIVWGARNLNFKALGKDFVDAMIRCNLDCTGYRGSQPIAQQTDVHYYSKTGAAIFNWRMVYSRVVMPVSTCVLQIAAYDNRNMGESPFIGEVNLELRRYLERVASTLNSIDVDAELKLINRSRESADVSSFGFVQVSLQFISQSEATSKPVGLGREPPNRDPRLTTPQEGRKWEDVLGSAGLRVDYRPLWYWVRVAAVVFLSIWIFVVAFLYPSLLG", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more C2_dom, C2_dom, C2_dom, C2_dom, C2_dom, C2_dom, C2_dom, C2_dom, C2_dom, C2F_Ferlin, C2_dom, C2_dom, C2_dom, C2_dom, C2_dom, C2_dom that are essential for its biological function; 2. The protein should belong to Ferlin that shares evolutionary origin and functional similarity; 3. The protein should be classified within C2_domain_sf, C2_domain_sf, C2_domain_sf, C2_domain_sf, C2_domain_sf, C2_domain_sf, C2_domain_sf, C2_domain_sf, C2_domain_sf, C2_domain_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MGKTKIYSVGFTVHEAQTLVTEKGQPVDPLVVVRCCGREYRTEIKYAKSNVVSWDESHTWTDLCLTDEEWETAYITFEVQAANAFWRNTLLGLVSVQLRLIQLRKTHQIRKALPLQHPDDTDVHGSLRVTVFACAPGEAPPSPGEEEVLEEEDHNDYDDLRKAVIDTNQVVEREAGSRLYHVYVTAYRVEDLPRSSKGARDPFVTCEFAGCKLKSTQARGCCSHTFNECFRFPVVTPLPEDAILIKIWDWNFMKADELIAVGRISFSELRTRQMVPRWFNLYGFDDEEVAQATKVAGQGGRLVANCYLGRILLGARAERLTKEDDLMPAHTVAARPYETPPVIPLAVLADVYEVQGAPGEKVSVEIWCGPARARTKWVTGLETKAAQRAGVAPQAFNRAMEGALGVASYLRGDIPEGEDRFPFDNTEGRVEDLRLVVPEDTKQQWDIIISLYVRGTTKGFMGDTRIAFQRLKMSKIPGHVHNNPRAPIWVPLISTPPFESVKPAPAILMVIEKSKVEAFARSKRKHVTAVGYQLRAYVYAARNLLSPSGALPNPFVQVACAGTSRETEVFEQTSSPVFMDCLLLDITMMTDPVSRLPTVAPIVVTLFEQRSWGIQFLGRATCHYDRLRGRLKPGESPTVAEPRWIKLRGGKYANRHLGDVLLLLELIRKRDAEIIPAFPMRPVVNMCNLTFSCLGVRSLYMTQRAKRLDYVSIRKGQDKKTELRRIRGPLLRISVSSYASAGRGNNEAILRYERNLPEDPTTVNKLWTTVTKAANADIFKVVNMEIDVPVDPIYDPRLVVQVYDRKQKPKYFIGEYSMSLVPLIPWVLDQQSAIEAVSPVNDFTDTVDLKHLGGLLRGFHGNSKNRGTGQIGLEALSAADRETADAHKEKTLAQSRFATYDPDNKTFSDSWLLPSGLPKILVSSYAVPGFRCDVIYTNMFTLNVYIPAKFVLFAEGKRAADKKTKEQYARPSVDSTLEQFLDDVIFPSDSLKKSVMGDIDVTGFVKFFVNLTHHEEPNPHVDSSAAEWASSEDRMRRHLRGEDAYPKLLKIRVYVIRAISLYVGDDRILPNPYLLFNLGDKSDTLRAEAKPNTHNPEFFTVWEKDVMFPDDSQFELQVWSAHEGTSGGLDDIFIGSTCIDLEERWFSKEWQKSMSKNQVPMEYRPLKQMPSGSFKGTVEMWVELMDFQKAGEVPKFDLQSPAATEVEIRVIVWGARNLNFKALGKDFVDAMIRCNLDCTGYRGSQPIAQQTDVHYYSKTGAAIFNWRMVYSRVVMPVSTCVLQIAAYDNRNMGESPFIGEVNLELRRYLERVASTLNSIDVDAELKLINRSRESADVSSFGFVQVSLQFISQSEATSKPVGLGREPPNRDPRLTTPQEGRKWEDVLGSAGLRVDYRPLWYWVRVAAVVFLSIWIFVVAFLYPSLLG" }, { "InterPro": [ { "InterPro-ID": "IPR000001", "InterPro-Name": "Kringle", "InterPro-Type": "DOMAIN", "Beg": 577, "End": 644 }, { "InterPro-ID": "IPR000001", "InterPro-Name": "Kringle", "InterPro-Type": "DOMAIN", "Beg": 582, "End": 644 }, { "InterPro-ID": "IPR011641", "InterPro-Name": "Tyr-kin_ephrin_A/B_rcpt-like", "InterPro-Type": "DOMAIN", "Beg": 1937, "End": 1981 }, { "InterPro-ID": "IPR011641", "InterPro-Name": "Tyr-kin_ephrin_A/B_rcpt-like", "InterPro-Type": "DOMAIN", "Beg": 1493, "End": 1546 }, { "InterPro-ID": "IPR011641", "InterPro-Name": "Tyr-kin_ephrin_A/B_rcpt-like", "InterPro-Type": "DOMAIN", "Beg": 1560, "End": 1601 }, { "InterPro-ID": "IPR011641", "InterPro-Name": "Tyr-kin_ephrin_A/B_rcpt-like", "InterPro-Type": "DOMAIN", "Beg": 1704, "End": 1744 }, { "InterPro-ID": "IPR013806", "InterPro-Name": "Kringle-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 577, "End": 645 }, { "InterPro-ID": "IPR018056", "InterPro-Name": "Kringle_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 619, "End": 631 }, { "InterPro-ID": "IPR019562", "InterPro-Name": "Micronemal-adhesive-rpt_sia-bd", "InterPro-Type": "REPEAT", "Beg": 427, "End": 472 }, { "InterPro-ID": "IPR000001", "InterPro-Name": "Kringle", "InterPro-Type": "DOMAIN", "Beg": 572, "End": 644 }, { "InterPro-ID": "IPR056048", "InterPro-Name": "CRMPA/B-like_DUF7631", "InterPro-Type": "DOMAIN", "Beg": 2118, "End": 2165 }, { "InterPro-ID": "IPR009030", "InterPro-Name": "Growth_fac_rcpt_cys_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1489, "End": 1652 }, { "InterPro-ID": "IPR009030", "InterPro-Name": "Growth_fac_rcpt_cys_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1920, "End": 2076 }, { "InterPro-ID": "IPR056047", "InterPro-Name": "CRMPA-like_DUF7630", "InterPro-Type": "DOMAIN", "Beg": 2182, "End": 2226 }, { "InterPro-ID": "IPR038178", "InterPro-Name": "Kringle_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 583, "End": 652 }, { "InterPro-ID": "IPR000001", "InterPro-Name": "Kringle", "InterPro-Type": "DOMAIN", "Beg": 581, "End": 644 } ], "response#1": "MDSASTSMSRVHPSGVYRRPLLPSGGPRSTSERDERVDLSGCPRHVERGTCLSLPPSFSAAAVDACLDSRCQVLSTAASGGCMQSATEHLRVSTRPCVASTHANSGTFAAVRSRVQRGQALSLFLLFSSSPLLLLLLLHQFFISSLHTEAVLGSPLLPALAVEVSSPEALKTTFEEREADSHRGSRDGEKVSGSRDIRFEEQEIRSRDGKETIFPSPHGDQPSGAGAWTSEGRRKKRSFYRDHIERGTSHPAFSFFSDPTSRFVLDPHLPASHASTCERGASCSPVDAIQPVFVSPSHSGNESEKAERARLEQSTPAKLWRPPKVFAESFASERRQTDTGLVSLHGDVAFRSPGFTVSIKRQAQKEWEREQLREKLLAEGGDLSMLEVQDDNDSGEIYLYSSMQLALDRQCVSQAEAMKTDWSYVRLHASNFYCFSKDDLNFETTGQNCVDSCSQTVACAGVPTTRAIRNITDTAKLPDNILGRNWPLKHCVTSRLQDALNEICGSPESIYRVVNDVAGCVPVESIDWTEASPVCVDDCNKVVNCYGQVTNADQMVPFTSDQRAMLETRKKSTCLCDETLEQGKLYRGCQTRTRTGRECQRWDVDSPHEHFELREAHNYCRNVNAEAEIWCYTTDPHVRFDFCDPLGVSERFVQPGETVDIVISGVDLSPHYSLRIYKGSETNVCGANNGQRAPAAFKDWGVERHFLPKYSVTDGTISLLTWPDLGIEPTATGKIALCACNFFGFLASNWNGATPCSQDSHFNVQLGVLHVIGPVHASGGEVQMISGVPHEFTVRGAGLRTVDTLVAVGDRTGVMCTSPNFFQMQLELLRGVGDGAFAVFTKGIATGENQYVKTGFKSVTSDGLLATTGDLTLLATGHYCLCWQGTNNGQRAYGLVDKLVVTGVDLSLTYRSVYSPSAGSASQKLFSTFIHTYRLSKDFADDALTVRTATKTPCEGTVVAQSRKIEKEYRSTTQMATEKLLYKAKYMSVKNLPESSTTYSEMLHVCLKSPNGEVLQFLGESSISEYYSYPFHDFVLPETLHVRTPSSVYSYTVSEFSNLGLHWGTVERDGEVVIGNFLDFFTANPFSKVLHFWLSHSGNVITAWAFSASDPSPTLMATFKSEFPVGMALHTTANFVHLYLLKGQTPATLFVMDVTVPSTGLSPEALIHALDPGQAGLVEPSNIVLIYEGEEDESDPVVVLVDSGTGYIHLFDHDLQEVGKSNGQEALAQPLVKPTDLHCLRKTEGSGTVSSVWDCFATDVGLPRVIYFSIDASTKEFRFLTTYSGEGTKDGVNTNLRGPISVVAHYFSGKTLIYVAEAASAYPLLLTKVDEEETLHYYAYLSQNSVGSSSTVGRLSLLHFSDDNSSLEHVSLATFRDAWRGAEVQIVSLDTTATVPNFRYHPHEWYTVGDTHSLEPSVIGLGTLKGVRKFALSTEIPNAAYVHSIASVDPNTGVVKLELTHIQRASVEIQVIAQGMVSQMTTTFKFNVACKDGYYYSQGMCVRCAAGTYNSVNLIKADPASSWAKCRKCGENHTTVAEGSISEDQCQCQLGFHIPDESEEGAKCEPCPAGMWKDTVANTGCIGSCPAHSSTTVVGAKSAEERRCECDAGYYFVGESVLNQECVLAEKGYFSEGGFEAERVPCPQHSTTNPNDDPSFVSRNLEACVCEKGYTPASLQSLEDSSSPEWKLMEWLKIHPKHTQLAKSQVCVPCGRGFYKDSIGAHACTPCPLNSFAATSVATSAAECELCQPGYYQTGNSDVPCGECPEGHFCVGSEPTVSSLSQYAGAKIMCPDNTATVPPNAQNDHPYKCMCQEGFEFSKVDSVTPTVICQPARVGDYKGVVSNTPGQRCPSGSSTQSTGSVSLEDCICTPGYFFSEASGECTECPVGFYCPGGRDSLTASHTMPVQCPAETNTRGTMSATSAECVCDKGYYRFSSQVNSGDIVCRPCPANSFKDWVGNDVCKACSENSGTEQTGANSASQCLCSRGFYYDISQAECVACSNPLKYCPGGEVECEEEEDNCVNGKKPAEPQACPPHTRITAGYDTPWSLDDCKCDPGFAYESGSAADGEKRCEPCSAGSYKSSVQDGPCNGLCGTSSTSFPGAQTQSQCFCEEGTYFAADACHTCPIGAFCGGGLLEEAEAKLREDSSFTGITSADHVKPFAEAGYFLNKLKEELESPNDWQFTECPIQNACLSHGVCSETMTEYLCSECRRGYTNTFSKGEICTSCPSMVWNIVCLMGYYLATLLFNIVMTYMNVAAGFNRRSIHSIVIKIASNYLTGISVLSVIDFSTIAFPSWITDLTATVTETVSAKHSTRLMSVDCLLRDNFDLSFSESFFYTMVFYALIPIALPIVATIIMSIIVYRVRAWYHNSTQRKLELLKQTMQYGLYSLAQQLKEKYEEDRVFMIFRYIALPGESIFRRAAKFMEDMIPIYVTVLFFVYSSTTRNMLSLLDCTYIDFGRAHQAKYFLRAAMSVECTDILSGPYFKFFAVGITGLLVWSIGIPLSCFLVLYVNRKTLNSRETRLKYGFLHNGFVKKYWYWEMVVFARKFLVIVVSSVALIPSADKNGSRVWLAVVIAVIFLIIHLVTQPFDKRSYLTLDKLENHSMTIWTITLIVLAMMIGSDFSGSVNMALLLFVAVLSCMFILEVGVSLMFAYFDNVRTQQTFFRVPVIGYVFRFFARLSEKRRAREPIVVFDTENEVIQLVAAKRQTWTLFRALRKNINLAERNYFIKVMSESLGFAVVHMKLDVIPGSFLEFALRLGLAFHRVEEVSQQNKKSLQAIADGDLSQLADWSNNEHKRKDLSESAKTSQKKLATELDTFYTDMEEKFAAKDETPTAEEKTEEQDERLHDLEGELVSDTELEQMKKTMTEAEEAEEDEDRGDDAAYLRNLQDFTNDITGEDEETMYLFDQDMMTRGIALSELYLALLKLQMQDSNTINSQFDAFRLRKQIQADEFSEALQKRNRKLKVMREALESLVLSSGTSLAELGMTEEAFQSKQAELQKLNAEIEKLKTRLQELKDNPDSYREGGDVEREEDWVDEDRAAEIEKIQEENARRKLEKEEREEADREICMTGEDMENAGWFGEDDTATIDDSSDAPLPEGTFRLIGQDAETWDEFGYSSSKGNYEAAPDDGL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Kringle, Kringle, Tyr-kin_ephrin_A/B_rcpt-like, Tyr-kin_ephrin_A/B_rcpt-like, Tyr-kin_ephrin_A/B_rcpt-like, Tyr-kin_ephrin_A/B_rcpt-like, Kringle, CRMPA/B-like_DUF7631, CRMPA-like_DUF7630, Kringle that are essential for its biological function; 2. The protein should be classified within Kringle-like, Growth_fac_rcpt_cys_sf, Growth_fac_rcpt_cys_sf, Kringle_sf sharing conserved structural features; 3. The protein should include one or more Micronemal-adhesive-rpt_sia-bd that provide structural or functional support; 4. The protein should contain Kringle_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MDSASTSMSRVHPSGVYRRPLLPSGGPRSTSERDERVDLSGCPRHVERGTCLSLPPSFSAAAVDACLDSRCQVLSTAASGGCMQSATEHLRVSTRPCVASTHANSGTFAAVRSRVQRGQALSLFLLFSSSPLLLLLLLHQFFISSLHTEAVLGSPLLPALAVEVSSPEALKTTFEEREADSHRGSRDGEKVSGSRDIRFEEQEIRSRDGKETIFPSPHGDQPSGAGAWTSEGRRKKRSFYRDHIERGTSHPAFSFFSDPTSRFVLDPHLPASHASTCERGASCSPVDAIQPVFVSPSHSGNESEKAERARLEQSTPAKLWRPPKVFAESFASERRQTDTGLVSLHGDVAFRSPGFTVSIKRQAQKEWEREQLREKLLAEGGDLSMLEVQDDNDSGEIYLYSSMQLALDRQCVSQAEAMKTDWSYVRLHASNFYCFSKDDLNFETTGQNCVDSCSQTVACAGVPTTRAIRNITDTAKLPDNILGRNWPLKHCVTSRLQDALNEICGSPESIYRVVNDVAGCVPVESIDWTEASPVCVDDCNKVVNCYGQVTNADQMVPFTSDQRAMLETRKKSTCLCDETLEQGKLYRGCQTRTRTGRECQRWDVDSPHEHFELREAHNYCRNVNAEAEIWCYTTDPHVRFDFCDPLGVSERFVQPGETVDIVISGVDLSPHYSLRIYKGSETNVCGANNGQRAPAAFKDWGVERHFLPKYSVTDGTISLLTWPDLGIEPTATGKIALCACNFFGFLASNWNGATPCSQDSHFNVQLGVLHVIGPVHASGGEVQMISGVPHEFTVRGAGLRTVDTLVAVGDRTGVMCTSPNFFQMQLELLRGVGDGAFAVFTKGIATGENQYVKTGFKSVTSDGLLATTGDLTLLATGHYCLCWQGTNNGQRAYGLVDKLVVTGVDLSLTYRSVYSPSAGSASQKLFSTFIHTYRLSKDFADDALTVRTATKTPCEGTVVAQSRKIEKEYRSTTQMATEKLLYKAKYMSVKNLPESSTTYSEMLHVCLKSPNGEVLQFLGESSISEYYSYPFHDFVLPETLHVRTPSSVYSYTVSEFSNLGLHWGTVERDGEVVIGNFLDFFTANPFSKVLHFWLSHSGNVITAWAFSASDPSPTLMATFKSEFPVGMALHTTANFVHLYLLKGQTPATLFVMDVTVPSTGLSPEALIHALDPGQAGLVEPSNIVLIYEGEEDESDPVVVLVDSGTGYIHLFDHDLQEVGKSNGQEALAQPLVKPTDLHCLRKTEGSGTVSSVWDCFATDVGLPRVIYFSIDASTKEFRFLTTYSGEGTKDGVNTNLRGPISVVAHYFSGKTLIYVAEAASAYPLLLTKVDEEETLHYYAYLSQNSVGSSSTVGRLSLLHFSDDNSSLEHVSLATFRDAWRGAEVQIVSLDTTATVPNFRYHPHEWYTVGDTHSLEPSVIGLGTLKGVRKFALSTEIPNAAYVHSIASVDPNTGVVKLELTHIQRASVEIQVIAQGMVSQMTTTFKFNVACKDGYYYSQGMCVRCAAGTYNSVNLIKADPASSWAKCRKCGENHTTVAEGSISEDQCQCQLGFHIPDESEEGAKCEPCPAGMWKDTVANTGCIGSCPAHSSTTVVGAKSAEERRCECDAGYYFVGESVLNQECVLAEKGYFSEGGFEAERVPCPQHSTTNPNDDPSFVSRNLEACVCEKGYTPASLQSLEDSSSPEWKLMEWLKIHPKHTQLAKSQVCVPCGRGFYKDSIGAHACTPCPLNSFAATSVATSAAECELCQPGYYQTGNSDVPCGECPEGHFCVGSEPTVSSLSQYAGAKIMCPDNTATVPPNAQNDHPYKCMCQEGFEFSKVDSVTPTVICQPARVGDYKGVVSNTPGQRCPSGSSTQSTGSVSLEDCICTPGYFFSEASGECTECPVGFYCPGGRDSLTASHTMPVQCPAETNTRGTMSATSAECVCDKGYYRFSSQVNSGDIVCRPCPANSFKDWVGNDVCKACSENSGTEQTGANSASQCLCSRGFYYDISQAECVACSNPLKYCPGGEVECEEEEDNCVNGKKPAEPQACPPHTRITAGYDTPWSLDDCKCDPGFAYESGSAADGEKRCEPCSAGSYKSSVQDGPCNGLCGTSSTSFPGAQTQSQCFCEEGTYFAADACHTCPIGAFCGGGLLEEAEAKLREDSSFTGITSADHVKPFAEAGYFLNKLKEELESPNDWQFTECPIQNACLSHGVCSETMTEYLCSECRRGYTNTFSKGEICTSCPSMVWNIVCLMGYYLATLLFNIVMTYMNVAAGFNRRSIHSIVIKIASNYLTGISVLSVIDFSTIAFPSWITDLTATVTETVSAKHSTRLMSVDCLLRDNFDLSFSESFFYTMVFYALIPIALPIVATIIMSIIVYRVRAWYHNSTQRKLELLKQTMQYGLYSLAQQLKEKYEEDRVFMIFRYIALPGESIFRRAAKFMEDMIPIYVTVLFFVYSSTTRNMLSLLDCTYIDFGRAHQAKYFLRAAMSVECTDILSGPYFKFFAVGITGLLVWSIGIPLSCFLVLYVNRKTLNSRETRLKYGFLHNGFVKKYWYWEMVVFARKFLVIVVSSVALIPSADKNGSRVWLAVVIAVIFLIIHLVTQPFDKRSYLTLDKLENHSMTIWTITLIVLAMMIGSDFSGSVNMALLLFVAVLSCMFILEVGVSLMFAYFDNVRTQQTFFRVPVIGYVFRFFARLSEKRRAREPIVVFDTENEVIQLVAAKRQTWTLFRALRKNINLAERNYFIKVMSESLGFAVVHMKLDVIPGSFLEFALRLGLAFHRVEEVSQQNKKSLQAIADGDLSQLADWSNNEHKRKDLSESAKTSQKKLATELDTFYTDMEEKFAAKDETPTAEEKTEEQDERLHDLEGELVSDTELEQMKKTMTEAEEAEEDEDRGDDAAYLRNLQDFTNDITGEDEETMYLFDQDMMTRGIALSELYLALLKLQMQDSNTINSQFDAFRLRKQIQADEFSEALQKRNRKLKVMREALESLVLSSGTSLAELGMTEEAFQSKQAELQKLNAEIEKLKTRLQELKDNPDSYREGGDVEREEDWVDEDRAAEIEKIQEENARRKLEKEEREEADREICMTGEDMENAGWFGEDDTATIDDSSDAPLPEGTFRLIGQDAETWDEFGYSSSKGNYEAAPDDGL" }, { "InterPro": [ { "InterPro-ID": "IPR013087", "InterPro-Name": "Znf_C2H2_type", "InterPro-Type": "DOMAIN", "Beg": 389, "End": 412 }, { "InterPro-ID": "IPR013087", "InterPro-Name": "Znf_C2H2_type", "InterPro-Type": "DOMAIN", "Beg": 418, "End": 440 }, { "InterPro-ID": "IPR036236", "InterPro-Name": "Znf_C2H2_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 387, "End": 440 }, { "InterPro-ID": "IPR013087", "InterPro-Name": "Znf_C2H2_type", "InterPro-Type": "DOMAIN", "Beg": 391, "End": 412 }, { "InterPro-ID": "IPR051059", "InterPro-Name": "VerF-like", "InterPro-Type": "FAMILY", "Beg": 363, "End": 509 }, { "InterPro-ID": "IPR013087", "InterPro-Name": "Znf_C2H2_type", "InterPro-Type": "DOMAIN", "Beg": 389, "End": 417 }, { "InterPro-ID": "IPR013087", "InterPro-Name": "Znf_C2H2_type", "InterPro-Type": "DOMAIN", "Beg": 420, "End": 440 } ], "response#1": "MEHQYMTQTPMQSPMYYYTPQKQQQIHYNSHMAPQNMDYFSQPISSHVLYSQRSSPVFQQQPQYISQAMLTPAASPRPQHQKPTIMLQQEMPSMNMSFDSDCYGPATPTLSATSFNSADSPNYHMMPTPANELHMNPFDGLKQNCEDDMFGEWTQSTSPPLTPAEVYLHPASAFTENSSYLLSTSACPSLSPSPSPSVCDPRTLTVPSNAFPCLPTLCAGDDEEHKLILKGDFTPSKTFDASELMPANHGFPTFEPLFELDVEDEFSASKRQRVDSQFTADSSFCFTDASFSDEDLTFSPCQSEFSFTSGPVVDMTPVRRSASKRAPKVAQYSAAAHSSANQPQQLPSNAAAASSSASSDDHSHSHPSTSSTTRRGRKQSLTEDPSKTFVCTLCSRRFRRQEHLKRHYRSLHTHDKPFECTDCGKKFSRSDNLSQHQRTHGAGTVVMGVMTSDMTSQMAVNVPDVGSGVLRPKSESPDASELGAMLFDHAAAVAGSSSGSQSGYDSAEDNSFQQKKRKRDE", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Znf_C2H2_type, Znf_C2H2_type, Znf_C2H2_type, Znf_C2H2_type, Znf_C2H2_type that are essential for its biological function; 2. The protein should belong to VerF-like that shares evolutionary origin and functional similarity; 3. The protein should be classified within Znf_C2H2_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MEHQYMTQTPMQSPMYYYTPQKQQQIHYNSHMAPQNMDYFSQPISSHVLYSQRSSPVFQQQPQYISQAMLTPAASPRPQHQKPTIMLQQEMPSMNMSFDSDCYGPATPTLSATSFNSADSPNYHMMPTPANELHMNPFDGLKQNCEDDMFGEWTQSTSPPLTPAEVYLHPASAFTENSSYLLSTSACPSLSPSPSPSVCDPRTLTVPSNAFPCLPTLCAGDDEEHKLILKGDFTPSKTFDASELMPANHGFPTFEPLFELDVEDEFSASKRQRVDSQFTADSSFCFTDASFSDEDLTFSPCQSEFSFTSGPVVDMTPVRRSASKRAPKVAQYSAAAHSSANQPQQLPSNAAAASSSASSDDHSHSHPSTSSTTRRGRKQSLTEDPSKTFVCTLCSRRFRRQEHLKRHYRSLHTHDKPFECTDCGKKFSRSDNLSQHQRTHGAGTVVMGVMTSDMTSQMAVNVPDVGSGVLRPKSESPDASELGAMLFDHAAAVAGSSSGSQSGYDSAEDNSFQQKKRKRDE" }, { "InterPro": [ { "InterPro-ID": "IPR045851", "InterPro-Name": "AMP-bd_C_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1744, "End": 1820 }, { "InterPro-ID": "IPR036736", "InterPro-Name": "ACP-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 799, "End": 869 }, { "InterPro-ID": "IPR036736", "InterPro-Name": "ACP-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 798, "End": 870 }, { "InterPro-ID": "IPR036736", "InterPro-Name": "ACP-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 2288, "End": 2362 }, { "InterPro-ID": "IPR029063", "InterPro-Name": "SAM-dependent_MTases_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1842, "End": 2025 }, { "InterPro-ID": "IPR036736", "InterPro-Name": "ACP-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 2290, "End": 2353 }, { "InterPro-ID": "IPR013217", "InterPro-Name": "Methyltransf_12", "InterPro-Type": "DOMAIN", "Beg": 1874, "End": 1971 }, { "InterPro-ID": "IPR013120", "InterPro-Name": "Far_NAD-bd", "InterPro-Type": "DOMAIN", "Beg": 2423, "End": 2656 }, { "InterPro-ID": "IPR029063", "InterPro-Name": "SAM-dependent_MTases_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1827, "End": 1977 }, { "InterPro-ID": "IPR010071", "InterPro-Name": "AA_adenyl_dom", "InterPro-Type": "DOMAIN", "Beg": 1369, "End": 1771 }, { "InterPro-ID": "IPR010071", "InterPro-Name": "AA_adenyl_dom", "InterPro-Type": "DOMAIN", "Beg": 290, "End": 683 }, { "InterPro-ID": "IPR006162", "InterPro-Name": "Ppantetheine_attach_site", "InterPro-Type": "PTM", "Beg": 2322, "End": 2337 }, { "InterPro-ID": "IPR045851", "InterPro-Name": "AMP-bd_C_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 2172, "End": 2284 }, { "InterPro-ID": "IPR045851", "InterPro-Name": "AMP-bd_C_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 661, "End": 780 }, { "InterPro-ID": "IPR042099", "InterPro-Name": "ANL_N_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1336, "End": 1742 }, { "InterPro-ID": "IPR006162", "InterPro-Name": "Ppantetheine_attach_site", "InterPro-Type": "PTM", "Beg": 831, "End": 846 }, { "InterPro-ID": "IPR020806", "InterPro-Name": "PKS_PP-bd", "InterPro-Type": "DOMAIN", "Beg": 2296, "End": 2356 }, { "InterPro-ID": "IPR020806", "InterPro-Name": "PKS_PP-bd", "InterPro-Type": "DOMAIN", "Beg": 805, "End": 871 }, { "InterPro-ID": "IPR009081", "InterPro-Name": "PP-bd_ACP", "InterPro-Type": "DOMAIN", "Beg": 2290, "End": 2368 }, { "InterPro-ID": "IPR009081", "InterPro-Name": "PP-bd_ACP", "InterPro-Type": "DOMAIN", "Beg": 799, "End": 875 }, { "InterPro-ID": "IPR009081", "InterPro-Name": "PP-bd_ACP", "InterPro-Type": "DOMAIN", "Beg": 807, "End": 869 }, { "InterPro-ID": "IPR009081", "InterPro-Name": "PP-bd_ACP", "InterPro-Type": "DOMAIN", "Beg": 2298, "End": 2353 }, { "InterPro-ID": "IPR000873", "InterPro-Name": "AMP-dep_synth/lig_dom", "InterPro-Type": "DOMAIN", "Beg": 1350, "End": 1689 }, { "InterPro-ID": "IPR000873", "InterPro-Name": "AMP-dep_synth/lig_dom", "InterPro-Type": "DOMAIN", "Beg": 270, "End": 607 }, { "InterPro-ID": "IPR036291", "InterPro-Name": "NAD(P)-bd_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 2420, "End": 2696 }, { "InterPro-ID": "IPR042099", "InterPro-Name": "ANL_N_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 263, "End": 660 }, { "InterPro-ID": "IPR010080", "InterPro-Name": "Thioester_reductase-like_dom", "InterPro-Type": "DOMAIN", "Beg": 2420, "End": 2738 }, { "InterPro-ID": "IPR001242", "InterPro-Name": "Condensatn", "InterPro-Type": "DOMAIN", "Beg": 914, "End": 1328 }, { "InterPro-ID": "IPR023213", "InterPro-Name": "CAT-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 906, "End": 1088 } ], "response#1": "MISETFCKSSADEGYTSFPIRPTSIDRPVLDKTSQCEFALFPHFCNIHTLSTLSNASWALIAGQLTNSTKIILGVPSSGESTPVHDIESRTALQPAAVPLLIDWRPEQSVADYLNHVQSRIADATALDGASSQLLAGGFPGDNYARHIQTLIVVETIETSPGSINGTQKLQRLEYDHKKNSACATLVIEMRLQKTGIMADASFDTRALGPWLVYNLLKRLEYVMKQLCCVSSGHVLADIDMITPEDLEQIWQCNDPIPAPVERCMHDVVQERCRLQPNALAVDAWDGRLTYRELDQLSDRLAGRLVNQGIEPDMLVPLCFHKSMWMPVTMMGVLKAGGGFVLLEPSFPEQRLRAMVEEIKPSIILASSTTRALSLRLLDNVIQVDSELFNYPNPSANGFPQLQPSSTAMFGVFTSGSTGKPKGAILTHANYCSAFTYQLDLLGFKKDSRVFDFASYAFDVSVHNVFASLASGACLCIASEEERRQDICKSISDMRATIVHLTPSVTRLIQPEKVPLLQTVIFTGEPLSVEDVKPWWGKVNIVNEYGPAECTINTINSNPSSPEEATMIGKGVGVAVWIVDPNDHDLLAPIGSVGELLIEGALVGRGYINETERNAAAFIENPKWLLHGRPGRPGRQGRLYKTGDLVKYGEDGNLIFVGRKDTQVKIYGQRVDLREVEHWIQSCGHGAGQVVAEMIAPRADDPAPALVAFLQIGHTGLGGPLCPNSTEATLRPVPDEVEAKLAKHLPSYMVPKMFIAMSQFPMTATGKTDRRQLRKIGSSFSLEQLAEVRAKARGRLERQPLTGMERLLCDVWSKVLRLERRTIGPESNFFHLGGDSIAAMKSVGEARKSGIKVAVADVFRHPSLQDLSRQSRYIEDNSLDHIEPFDLLGEVFNRVSFLKDASHQYGIDPSAIYDAYPCTPLQEGLMSLTAKRPGDYIEQMILELGGDVEVDNLWVAWDHVARVTPILRTRLVHHNDLGLVQLVLEENTSRTDATGLDEYLDADRRRSMSLGEPLSRYGLVRNETGEPKWFVWSIHHAIYDGWSVQLILDAAYRAYRGEKIQQGPQFQVFIKYVQQQRHHNQGRVVEYWQKTLAGFKGTQFPSVVPSVQQPVADTSLCCCIPNPQNSRVGVTTSMLIRAAWALVVGTMANSEDVVFGSTLYGRNASVAGLEELAAPTIATVPVRVRFSRNQTVSEYLEAIQQEATAMIPFEQTGLQEIAQISDSCQMACQFQTHLVIQPEEHAQGKGPLGTWQIRSQEQWFSTYSLTLELWLGTDHITASAMFDSRIIESWVVRSMLQRLEGVMYQLNYATSSQLLGDITILTTEDLEQIWEWNKTIPTPVNRCVHEIIHDKVQARPNAPAICAWDGELTYNELNRLADQLSGRLTELGVGPHLLVPLCFEKSLWTAVAILGVIKSGGGFVLLDASLPEQRLRSIMQQVKGDLVITCPSQQALCSRLGAQTITLSWGFFSTLRGYEAGLRIQEYSPSSILYAVFTSGSTGTPKGVLITHGNMASALHYQSEAMGLSEDSRLYDFASYSFDVAISNIFTVLAAGGCLCVPSEEHRKNNLEGSIISLRANALDLTPSIAQLLSSARLLNVRSLTLGGESVLATAAEPWFGKLQMRNAYGPSECTPTCIINHNPSSPEQATEIGNGVGVVTWVVDPSNHEVLLPPGCTGELLLEGPLVGPGYLGDGEKTAAAFIHDPVWLTKGTHNRTGRHGRLYKTGDLVKYNKNGTLSFVRRKDTQIKLRGQRVELGEVEHVLRSHSCVVDAVAVSQRDDKLGAWIAGFVTIRADGQKKHQGDGEYEQQQIQSWEDQFDGETYTSIEAMPREAIGRDFIGWTSMYDGSDIDKGDMNEWLDDTINTILDGGPVGHVLEIGCGSGMMLFNLANKGLQSYIGIEPSRRAVDATTRIANSIPNLKERIRIVKGTGEDLQRLGTRLGTPISPDLVVINSVIQYFPSQEYLVKLIQDIFKLGSVKTIFFGDVRSHALHKEFLALRALQILGETASREEIGQVLSNLHRAEPELLLDPEFFTSLPARLPGHIAHVEILPKKMEATNELSSFRYGAVVHLDLEHRQTPDIDPKSWVSYTSRGLDCKSLLALLKNRPEAADTIAICDIPHSKTVFATELIDDLENGASEARHSRHWAQFICQKAKQRSSLSAIDLVKLAEEAGYRVEISWARQYSQRGGLDAVFHRCIADNDARRVLFRFPTDHTDRPYHFLSSKPLRRQAEIKIQKELEAKLRCQLPSHMIPQTITILDRMPANHNGKVDRQILADSVQRQWTGRGRRRSPTTDMEKELQRIWSHVLNISPDSIGLDDGFVHLGGNSLNAMKIVHMARQAGIDLTVADMFRYSETTIERLLLDCCCDDTCGKGTSADAVNWTYLMAAIDERDAYLAAIQAGEKSHLVNGDMQADSDNLLTVLLTGANGFIGTQILRQLLEHGRVDRVICIVRGESPSVARQRTIEAAKKALWWTEFHQEMLEVWPGDLSLPRLGLDEVKWRLLAEGKAANIIIHNGASVNFVKSYAALEAANVDSTVEMVSVVTRNPSMRLIYVSSARSQDPMEEEEEDMAQALTKNPNGYNQTKFIAEALVRRAALRTSPRQDQFMVVSPGLVVGTPTEGVANADDWLWRMAAACIRVGVYNVDNSDKWVPLCDVSTTATVIIEAALGHPSTSRTVTQVRGGLTMGEFWETLAAAGYPLVGTRVAECTAAIQEDILANGENHPLGALADMLQDLEDTTNVQWADSWRKNGLCSPARLKAALCKSAEFLSRVEFLPSPNLVHGRVVQETNMRAFTRSGF", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Methyltransf_12, Far_NAD-bd, AA_adenyl_dom, AA_adenyl_dom, PKS_PP-bd, PKS_PP-bd, PP-bd_ACP, PP-bd_ACP, PP-bd_ACP, PP-bd_ACP, AMP-dep_synth/lig_dom, AMP-dep_synth/lig_dom, Thioester_reductase-like_dom, Condensatn that are essential for its biological function; 2. The protein should be classified within AMP-bd_C_sf, ACP-like_sf, ACP-like_sf, ACP-like_sf, SAM-dependent_MTases_sf, ACP-like_sf, SAM-dependent_MTases_sf, AMP-bd_C_sf, AMP-bd_C_sf, ANL_N_sf, NAD(P)-bd_dom_sf, ANL_N_sf, CAT-like_dom_sf sharing conserved structural features; 3. The protein should contain Ppantetheine_attach_site, Ppantetheine_attach_site that allow regulation through chemical modifications. The designed protein sequence is ", "reference": "MISETFCKSSADEGYTSFPIRPTSIDRPVLDKTSQCEFALFPHFCNIHTLSTLSNASWALIAGQLTNSTKIILGVPSSGESTPVHDIESRTALQPAAVPLLIDWRPEQSVADYLNHVQSRIADATALDGASSQLLAGGFPGDNYARHIQTLIVVETIETSPGSINGTQKLQRLEYDHKKNSACATLVIEMRLQKTGIMADASFDTRALGPWLVYNLLKRLEYVMKQLCCVSSGHVLADIDMITPEDLEQIWQCNDPIPAPVERCMHDVVQERCRLQPNALAVDAWDGRLTYRELDQLSDRLAGRLVNQGIEPDMLVPLCFHKSMWMPVTMMGVLKAGGGFVLLEPSFPEQRLRAMVEEIKPSIILASSTTRALSLRLLDNVIQVDSELFNYPNPSANGFPQLQPSSTAMFGVFTSGSTGKPKGAILTHANYCSAFTYQLDLLGFKKDSRVFDFASYAFDVSVHNVFASLASGACLCIASEEERRQDICKSISDMRATIVHLTPSVTRLIQPEKVPLLQTVIFTGEPLSVEDVKPWWGKVNIVNEYGPAECTINTINSNPSSPEEATMIGKGVGVAVWIVDPNDHDLLAPIGSVGELLIEGALVGRGYINETERNAAAFIENPKWLLHGRPGRPGRQGRLYKTGDLVKYGEDGNLIFVGRKDTQVKIYGQRVDLREVEHWIQSCGHGAGQVVAEMIAPRADDPAPALVAFLQIGHTGLGGPLCPNSTEATLRPVPDEVEAKLAKHLPSYMVPKMFIAMSQFPMTATGKTDRRQLRKIGSSFSLEQLAEVRAKARGRLERQPLTGMERLLCDVWSKVLRLERRTIGPESNFFHLGGDSIAAMKSVGEARKSGIKVAVADVFRHPSLQDLSRQSRYIEDNSLDHIEPFDLLGEVFNRVSFLKDASHQYGIDPSAIYDAYPCTPLQEGLMSLTAKRPGDYIEQMILELGGDVEVDNLWVAWDHVARVTPILRTRLVHHNDLGLVQLVLEENTSRTDATGLDEYLDADRRRSMSLGEPLSRYGLVRNETGEPKWFVWSIHHAIYDGWSVQLILDAAYRAYRGEKIQQGPQFQVFIKYVQQQRHHNQGRVVEYWQKTLAGFKGTQFPSVVPSVQQPVADTSLCCCIPNPQNSRVGVTTSMLIRAAWALVVGTMANSEDVVFGSTLYGRNASVAGLEELAAPTIATVPVRVRFSRNQTVSEYLEAIQQEATAMIPFEQTGLQEIAQISDSCQMACQFQTHLVIQPEEHAQGKGPLGTWQIRSQEQWFSTYSLTLELWLGTDHITASAMFDSRIIESWVVRSMLQRLEGVMYQLNYATSSQLLGDITILTTEDLEQIWEWNKTIPTPVNRCVHEIIHDKVQARPNAPAICAWDGELTYNELNRLADQLSGRLTELGVGPHLLVPLCFEKSLWTAVAILGVIKSGGGFVLLDASLPEQRLRSIMQQVKGDLVITCPSQQALCSRLGAQTITLSWGFFSTLRGYEAGLRIQEYSPSSILYAVFTSGSTGTPKGVLITHGNMASALHYQSEAMGLSEDSRLYDFASYSFDVAISNIFTVLAAGGCLCVPSEEHRKNNLEGSIISLRANALDLTPSIAQLLSSARLLNVRSLTLGGESVLATAAEPWFGKLQMRNAYGPSECTPTCIINHNPSSPEQATEIGNGVGVVTWVVDPSNHEVLLPPGCTGELLLEGPLVGPGYLGDGEKTAAAFIHDPVWLTKGTHNRTGRHGRLYKTGDLVKYNKNGTLSFVRRKDTQIKLRGQRVELGEVEHVLRSHSCVVDAVAVSQRDDKLGAWIAGFVTIRADGQKKHQGDGEYEQQQIQSWEDQFDGETYTSIEAMPREAIGRDFIGWTSMYDGSDIDKGDMNEWLDDTINTILDGGPVGHVLEIGCGSGMMLFNLANKGLQSYIGIEPSRRAVDATTRIANSIPNLKERIRIVKGTGEDLQRLGTRLGTPISPDLVVINSVIQYFPSQEYLVKLIQDIFKLGSVKTIFFGDVRSHALHKEFLALRALQILGETASREEIGQVLSNLHRAEPELLLDPEFFTSLPARLPGHIAHVEILPKKMEATNELSSFRYGAVVHLDLEHRQTPDIDPKSWVSYTSRGLDCKSLLALLKNRPEAADTIAICDIPHSKTVFATELIDDLENGASEARHSRHWAQFICQKAKQRSSLSAIDLVKLAEEAGYRVEISWARQYSQRGGLDAVFHRCIADNDARRVLFRFPTDHTDRPYHFLSSKPLRRQAEIKIQKELEAKLRCQLPSHMIPQTITILDRMPANHNGKVDRQILADSVQRQWTGRGRRRSPTTDMEKELQRIWSHVLNISPDSIGLDDGFVHLGGNSLNAMKIVHMARQAGIDLTVADMFRYSETTIERLLLDCCCDDTCGKGTSADAVNWTYLMAAIDERDAYLAAIQAGEKSHLVNGDMQADSDNLLTVLLTGANGFIGTQILRQLLEHGRVDRVICIVRGESPSVARQRTIEAAKKALWWTEFHQEMLEVWPGDLSLPRLGLDEVKWRLLAEGKAANIIIHNGASVNFVKSYAALEAANVDSTVEMVSVVTRNPSMRLIYVSSARSQDPMEEEEEDMAQALTKNPNGYNQTKFIAEALVRRAALRTSPRQDQFMVVSPGLVVGTPTEGVANADDWLWRMAAACIRVGVYNVDNSDKWVPLCDVSTTATVIIEAALGHPSTSRTVTQVRGGLTMGEFWETLAAAGYPLVGTRVAECTAAIQEDILANGENHPLGALADMLQDLEDTTNVQWADSWRKNGLCSPARLKAALCKSAEFLSRVEFLPSPNLVHGRVVQETNMRAFTRSGF" }, { "InterPro": [ { "InterPro-ID": "IPR042099", "InterPro-Name": "ANL_N_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 224, "End": 617 }, { "InterPro-ID": "IPR009081", "InterPro-Name": "PP-bd_ACP", "InterPro-Type": "DOMAIN", "Beg": 1438, "End": 1514 }, { "InterPro-ID": "IPR010071", "InterPro-Name": "AA_adenyl_dom", "InterPro-Type": "DOMAIN", "Beg": 251, "End": 638 }, { "InterPro-ID": "IPR045851", "InterPro-Name": "AMP-bd_C_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 618, "End": 747 }, { "InterPro-ID": "IPR001242", "InterPro-Name": "Condensatn", "InterPro-Type": "DOMAIN", "Beg": 883, "End": 1293 }, { "InterPro-ID": "IPR001242", "InterPro-Name": "Condensatn", "InterPro-Type": "DOMAIN", "Beg": 1586, "End": 1978 }, { "InterPro-ID": "IPR009081", "InterPro-Name": "PP-bd_ACP", "InterPro-Type": "DOMAIN", "Beg": 1446, "End": 1508 }, { "InterPro-ID": "IPR009081", "InterPro-Name": "PP-bd_ACP", "InterPro-Type": "DOMAIN", "Beg": 772, "End": 832 }, { "InterPro-ID": "IPR036736", "InterPro-Name": "ACP-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1442, "End": 1524 }, { "InterPro-ID": "IPR036736", "InterPro-Name": "ACP-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 768, "End": 833 }, { "InterPro-ID": "IPR000873", "InterPro-Name": "AMP-dep_synth/lig_dom", "InterPro-Type": "DOMAIN", "Beg": 231, "End": 572 }, { "InterPro-ID": "IPR036736", "InterPro-Name": "ACP-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 769, "End": 834 }, { "InterPro-ID": "IPR036736", "InterPro-Name": "ACP-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1438, "End": 1509 }, { "InterPro-ID": "IPR009081", "InterPro-Name": "PP-bd_ACP", "InterPro-Type": "DOMAIN", "Beg": 763, "End": 840 }, { "InterPro-ID": "IPR023213", "InterPro-Name": "CAT-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 875, "End": 1060 }, { "InterPro-ID": "IPR023213", "InterPro-Name": "CAT-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1556, "End": 1733 }, { "InterPro-ID": "IPR020845", "InterPro-Name": "AMP-binding_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 374, "End": 385 }, { "InterPro-ID": "IPR006162", "InterPro-Name": "Ppantetheine_attach_site", "InterPro-Type": "PTM", "Beg": 795, "End": 810 }, { "InterPro-ID": "IPR020806", "InterPro-Name": "PKS_PP-bd", "InterPro-Type": "DOMAIN", "Beg": 1444, "End": 1514 }, { "InterPro-ID": "IPR020806", "InterPro-Name": "PKS_PP-bd", "InterPro-Type": "DOMAIN", "Beg": 769, "End": 840 } ], "response#1": "MVNLDFEVEPCLFPSLSTRSVNQSHGKAMAYQHGFEWEVTISEDSVFQGIVLSWNILLAKYTDSTTITFGVISGSEGNKCHDDTTVDEYCTSFHPESCLPTVLPLASRRQYRFHEWKYDARINTCIANGSHKVWLDHWINSPNHGIKLILVVEQGRWPCMSLYGKPSFIDEGSVRLLCTAFQHILDCVLENQMGLLKNIEVTPSHHYQRILDWNSHIPKEPLAECIHDLIQRRCMETPDAEAICAWDGTMSYAALEQESARTMEWLQHHGVGPETIVPLLFEKSKWTVVAVLGVLKAGAAFVLLETSHPIERLKSICHDIGACIILTSALCKEIGSNLADITMSVPCDVERKLPCGDGKMKPCIRAQPRNAAYVAYTSGSTGKPKGVIIEHASFCTNAMVSSEAQNLNGCSRVLQFASYAFDVSIHETLVPLMLGGCVCIPSASQRVNSLQEAIVQLRVNWMELTPSVTRLLSPHKIPNVKTLVVGGESISPAELARWAGHIRLNVAYGPAECTVVSMVQSNVTKHGDPLSIGRGCGGSVWIVEPQNHNVLVPIGAPGELLIGGPIVGRGYLNRPEQTAAVFIQNPPWQAENNSRFYKTGDVVRQNSDGSVVFLGRKDTQVKLRGQRIELGEIEYQASGFFPGAAVAVEVGKLYHGHPALVLFVEWKSLENRKRCSGTNCCRTVQNDKTHFMSNAQWAKAGLSQILPSYMVPDIIVPLCTIPLSHSAKVDRKALRAMITRWSKDEVKLYQVTANSTSCGRYPHHAGQKYDEMVRMVARVLSLDPSEVREHDNFFQLGGDSLSAIMLSREIDTIPLLSLTVADIFQSASIAELFHRSQKTPLPESMEPGIPTKVLPFSLLDPMKIDNYRERAAEHCGVSPSQIEDIYPCSPLQARLMARTSRQPGAFQGHFNFRLSLDTDWDRLHWAWNKAADFLPILRTRIINTWQLAEGNPLQVVVRDKDIEWVEVAASESEPKSRMSFGSPLIYCVAVRAKHSPVLILNIHHALFDLVVFEQILEAVKAAYQGKPLVWRPFSPFIKYVQDLNRSQANEFWKREFTGLRAVPFPADITPGRSNLDAIRWTRKSFCLGHQNQAGITLSSLIRLAWAMVLSQYTGSLDVVFGTTVMGRNMPGTADVGGPTIATYPLRITLRGEESIKEALQRIQNHGIAIAPFEQSGIQHIRHSSPESAIACSFRNMLVIQPSSDNSLLAKRDLSPLLVLEERGSWKQKSYVNFSTQALNVVCEPGAGHLDVSAYFDQSILSSQEVEEMLSCMDRLLQLVLQHPDASMGTILSQSQSPDGDLDRYEERTSLARLEQEACQYLGNGVRVAAVWIIPMASHVPKLALFVGAMSLNTVSDGRWILAGVKEPLRTRLVQMMHEFQNNPLGRAVPFCCIPVPLQYRPSMPGLFLDRARAQEAASKFTLKTLTSWQNTGDSGFEEPLLPLEATLRRALAKVLSLEPEAIGVNDDLVSLGCDSLVAMQFAAQCDRQSLRLTISEIFQATSLRCLASTLNSRPSGDPTPALEAFALLKPMYGDRESFEQDIQRSVDGWNIKESIDAFPCTTAHLGLLSGLGTCQSHTIWEIGSPEEQIDLVSFAKAWLNLVNRHAALRTLLLPSRSNPSEWLHVVLKSSPVGVKVVTKLKNASLLKIARKPLLSRDGLGGLPYRFAVYQSTTGRTLCKLEARYAFLDAFSVLVLMKELRRILDCLPTSDPLLPSYSSWVAYLRRWSEDPLHLQFWDRYLAGLKPCILRASRNHHHHQHEGRQHHGASETNGNRPRLIKSHRQIVVQDAVALRKYCDQRELTITNILQVAWALTLKEQTGIEDICFGALVSGRDVPVDHVGNIVGSLFNVLACRIQMPATDSISSVLLENQQMMRERASHQFCSLQEVTRLVLKARPEASSLFNTCLSVEQPLSDEAETGKGFRALETVEETEYDLIVAATVFPDRIQASIMYWSYFCDPARAATIAETFAQSIERIILCA", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more PP-bd_ACP, AA_adenyl_dom, Condensatn, Condensatn, PP-bd_ACP, PP-bd_ACP, AMP-dep_synth/lig_dom, PP-bd_ACP, PKS_PP-bd, PKS_PP-bd that are essential for its biological function; 2. The protein should be classified within ANL_N_sf, AMP-bd_C_sf, ACP-like_sf, ACP-like_sf, ACP-like_sf, ACP-like_sf, CAT-like_dom_sf, CAT-like_dom_sf sharing conserved structural features; 3. The protein should contain AMP-binding_CS that is preserved across related proteins; 4. The protein should contain Ppantetheine_attach_site that allow regulation through chemical modifications. The designed protein sequence is ", "reference": "MVNLDFEVEPCLFPSLSTRSVNQSHGKAMAYQHGFEWEVTISEDSVFQGIVLSWNILLAKYTDSTTITFGVISGSEGNKCHDDTTVDEYCTSFHPESCLPTVLPLASRRQYRFHEWKYDARINTCIANGSHKVWLDHWINSPNHGIKLILVVEQGRWPCMSLYGKPSFIDEGSVRLLCTAFQHILDCVLENQMGLLKNIEVTPSHHYQRILDWNSHIPKEPLAECIHDLIQRRCMETPDAEAICAWDGTMSYAALEQESARTMEWLQHHGVGPETIVPLLFEKSKWTVVAVLGVLKAGAAFVLLETSHPIERLKSICHDIGACIILTSALCKEIGSNLADITMSVPCDVERKLPCGDGKMKPCIRAQPRNAAYVAYTSGSTGKPKGVIIEHASFCTNAMVSSEAQNLNGCSRVLQFASYAFDVSIHETLVPLMLGGCVCIPSASQRVNSLQEAIVQLRVNWMELTPSVTRLLSPHKIPNVKTLVVGGESISPAELARWAGHIRLNVAYGPAECTVVSMVQSNVTKHGDPLSIGRGCGGSVWIVEPQNHNVLVPIGAPGELLIGGPIVGRGYLNRPEQTAAVFIQNPPWQAENNSRFYKTGDVVRQNSDGSVVFLGRKDTQVKLRGQRIELGEIEYQASGFFPGAAVAVEVGKLYHGHPALVLFVEWKSLENRKRCSGTNCCRTVQNDKTHFMSNAQWAKAGLSQILPSYMVPDIIVPLCTIPLSHSAKVDRKALRAMITRWSKDEVKLYQVTANSTSCGRYPHHAGQKYDEMVRMVARVLSLDPSEVREHDNFFQLGGDSLSAIMLSREIDTIPLLSLTVADIFQSASIAELFHRSQKTPLPESMEPGIPTKVLPFSLLDPMKIDNYRERAAEHCGVSPSQIEDIYPCSPLQARLMARTSRQPGAFQGHFNFRLSLDTDWDRLHWAWNKAADFLPILRTRIINTWQLAEGNPLQVVVRDKDIEWVEVAASESEPKSRMSFGSPLIYCVAVRAKHSPVLILNIHHALFDLVVFEQILEAVKAAYQGKPLVWRPFSPFIKYVQDLNRSQANEFWKREFTGLRAVPFPADITPGRSNLDAIRWTRKSFCLGHQNQAGITLSSLIRLAWAMVLSQYTGSLDVVFGTTVMGRNMPGTADVGGPTIATYPLRITLRGEESIKEALQRIQNHGIAIAPFEQSGIQHIRHSSPESAIACSFRNMLVIQPSSDNSLLAKRDLSPLLVLEERGSWKQKSYVNFSTQALNVVCEPGAGHLDVSAYFDQSILSSQEVEEMLSCMDRLLQLVLQHPDASMGTILSQSQSPDGDLDRYEERTSLARLEQEACQYLGNGVRVAAVWIIPMASHVPKLALFVGAMSLNTVSDGRWILAGVKEPLRTRLVQMMHEFQNNPLGRAVPFCCIPVPLQYRPSMPGLFLDRARAQEAASKFTLKTLTSWQNTGDSGFEEPLLPLEATLRRALAKVLSLEPEAIGVNDDLVSLGCDSLVAMQFAAQCDRQSLRLTISEIFQATSLRCLASTLNSRPSGDPTPALEAFALLKPMYGDRESFEQDIQRSVDGWNIKESIDAFPCTTAHLGLLSGLGTCQSHTIWEIGSPEEQIDLVSFAKAWLNLVNRHAALRTLLLPSRSNPSEWLHVVLKSSPVGVKVVTKLKNASLLKIARKPLLSRDGLGGLPYRFAVYQSTTGRTLCKLEARYAFLDAFSVLVLMKELRRILDCLPTSDPLLPSYSSWVAYLRRWSEDPLHLQFWDRYLAGLKPCILRASRNHHHHQHEGRQHHGASETNGNRPRLIKSHRQIVVQDAVALRKYCDQRELTITNILQVAWALTLKEQTGIEDICFGALVSGRDVPVDHVGNIVGSLFNVLACRIQMPATDSISSVLLENQQMMRERASHQFCSLQEVTRLVLKARPEASSLFNTCLSVEQPLSDEAETGKGFRALETVEETEYDLIVAATVFPDRIQASIMYWSYFCDPARAATIAETFAQSIERIILCA" }, { "InterPro": [ { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 435, "End": 446 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 320, "End": 333 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 426, "End": 435 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 355, "End": 366 }, { "InterPro-ID": "IPR036396", "InterPro-Name": "Cyt_P450_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 37, "End": 479 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 46, "End": 467 }, { "InterPro-ID": "IPR036396", "InterPro-Name": "Cyt_P450_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 46, "End": 468 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 395, "End": 419 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 98, "End": 119 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 311, "End": 337 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 354, "End": 372 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 74, "End": 93 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 184, "End": 202 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 435, "End": 458 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 425, "End": 435 }, { "InterPro-ID": "IPR050364", "InterPro-Name": "Cytochrome_P450_fung", "InterPro-Type": "FAMILY", "Beg": 19, "End": 517 }, { "InterPro-ID": "IPR017972", "InterPro-Name": "Cyt_P450_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 428, "End": 437 } ], "response#1": "MASEIYRRLPMELPAQHLLASLALVGALLSVGYLLLRPAKYQLPLPPGPRGLPIIGNLHQAPKEKAWEVYKQWSDRYGPIMSVNNGGMITIIVSSHEVVKNFLEKNNAVFSSRPQLLVLERALYGFTTPALPYGEKWLKHRALRGAVLKPAMAVRYRGLQDLESKQLLRDLLYSEDFTQCMRRQAASLFLGIAYGNRFPEETPEIIDIDQAVAQLGGISESMFQGTGMLREFFPVLKYFPGYDKFLKQLDDVGERLANIYVRRFRDGLSTPAWNWAKEYSKRPEAQGMGELELSFCIGSTYQASLTPYEILRIILLAAICHPEEKARLQKEIDLVVGKDNLPGWEHKDRIQFVQAFIYEALRWHAFSPLGAPRAVSRDIEYKGYFIPKGATLVLNQWAMDHDENVYDNPFTFRPQRWIDNPDLPHVIFGFGLRGCPGQHLARDHLFINTARLFWAFNFGNAYENGKKVELDLDELMQPRGGGSAFNQVPSFKASVIIRSSERRQIVENEWDAVEKDEQKILAEAMPLPE", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Cyt_P450, Cyt_P450, Cyt_P450, Cyt_P450, Cyt_P450, Cyt_P450_E_grp-I, Cyt_P450_E_grp-I, Cyt_P450_E_grp-I, Cyt_P450_E_grp-I, Cyt_P450_E_grp-I, Cyt_P450_E_grp-I, Cyt_P450_E_grp-I, Cyt_P450_E_grp-I, Cytochrome_P450_fung that shares evolutionary origin and functional similarity; 2. The protein should be classified within Cyt_P450_sf, Cyt_P450_sf sharing conserved structural features; 3. The protein should contain Cyt_P450_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MASEIYRRLPMELPAQHLLASLALVGALLSVGYLLLRPAKYQLPLPPGPRGLPIIGNLHQAPKEKAWEVYKQWSDRYGPIMSVNNGGMITIIVSSHEVVKNFLEKNNAVFSSRPQLLVLERALYGFTTPALPYGEKWLKHRALRGAVLKPAMAVRYRGLQDLESKQLLRDLLYSEDFTQCMRRQAASLFLGIAYGNRFPEETPEIIDIDQAVAQLGGISESMFQGTGMLREFFPVLKYFPGYDKFLKQLDDVGERLANIYVRRFRDGLSTPAWNWAKEYSKRPEAQGMGELELSFCIGSTYQASLTPYEILRIILLAAICHPEEKARLQKEIDLVVGKDNLPGWEHKDRIQFVQAFIYEALRWHAFSPLGAPRAVSRDIEYKGYFIPKGATLVLNQWAMDHDENVYDNPFTFRPQRWIDNPDLPHVIFGFGLRGCPGQHLARDHLFINTARLFWAFNFGNAYENGKKVELDLDELMQPRGGGSAFNQVPSFKASVIIRSSERRQIVENEWDAVEKDEQKILAEAMPLPE" }, { "InterPro": [ { "InterPro-ID": "IPR002403", "InterPro-Name": "Cyt_P450_E_grp-IV", "InterPro-Type": "FAMILY", "Beg": 468, "End": 484 }, { "InterPro-ID": "IPR002403", "InterPro-Name": "Cyt_P450_E_grp-IV", "InterPro-Type": "FAMILY", "Beg": 484, "End": 502 }, { "InterPro-ID": "IPR002403", "InterPro-Name": "Cyt_P450_E_grp-IV", "InterPro-Type": "FAMILY", "Beg": 359, "End": 375 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 131, "End": 513 }, { "InterPro-ID": "IPR017972", "InterPro-Name": "Cyt_P450_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 477, "End": 486 }, { "InterPro-ID": "IPR036396", "InterPro-Name": "Cyt_P450_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 127, "End": 536 }, { "InterPro-ID": "IPR036396", "InterPro-Name": "Cyt_P450_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 87, "End": 528 } ], "response#1": "MSLISPLAAVLSAMAIVLGLLFFPNMTPQPTLHPRVGWRKEKASTLRAALRSCYKLNDWALEGYNAYAKLNIPYVLPSFDRGPITIIPARLMRRLYTLPDTDLDIRMTQQETNQTRWVAWDKKPAEDTFVWDVLRKQITRNLRQLTPIVASEIELSFNRWWGTDKEWKSIDIWDSCWKIVTGGINTTLCGSPLCRDAEFLQSCQNHSLVLVAGAMAINGAPRLLQPIIGGLVWFVCAILFNTTMKRSKAVVQERLEKTAMLRAEPAYDWKPPQDAIQWIIDDLYASDNLTQLNVKTICFRLLLLNDVSIPSTSFSVQTLLLNLFAADPALGFLEALREECQTVYTESGGVWTYDALKKLKITESAIRESLRLSPVGGIGLHRTVVNPKGISLPDYRLNLPHGTVIASPIESIHYDDDIYPHANDYNAFRFADPEAVRAILDKLSSEPNSNISTGGPRDRESKSAASTANIDEAFLAFGIGKHICPGRFFVMVEMKLILAIILVHYDVKPVKFKPKLVDCLWLKVPWNSGTLVVRRRSN", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Cyt_P450_E_grp-IV, Cyt_P450_E_grp-IV, Cyt_P450_E_grp-IV, Cyt_P450 that shares evolutionary origin and functional similarity; 2. The protein should be classified within Cyt_P450_sf, Cyt_P450_sf sharing conserved structural features; 3. The protein should contain Cyt_P450_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MSLISPLAAVLSAMAIVLGLLFFPNMTPQPTLHPRVGWRKEKASTLRAALRSCYKLNDWALEGYNAYAKLNIPYVLPSFDRGPITIIPARLMRRLYTLPDTDLDIRMTQQETNQTRWVAWDKKPAEDTFVWDVLRKQITRNLRQLTPIVASEIELSFNRWWGTDKEWKSIDIWDSCWKIVTGGINTTLCGSPLCRDAEFLQSCQNHSLVLVAGAMAINGAPRLLQPIIGGLVWFVCAILFNTTMKRSKAVVQERLEKTAMLRAEPAYDWKPPQDAIQWIIDDLYASDNLTQLNVKTICFRLLLLNDVSIPSTSFSVQTLLLNLFAADPALGFLEALREECQTVYTESGGVWTYDALKKLKITESAIRESLRLSPVGGIGLHRTVVNPKGISLPDYRLNLPHGTVIASPIESIHYDDDIYPHANDYNAFRFADPEAVRAILDKLSSEPNSNISTGGPRDRESKSAASTANIDEAFLAFGIGKHICPGRFFVMVEMKLILAIILVHYDVKPVKFKPKLVDCLWLKVPWNSGTLVVRRRSN" }, { "InterPro": [ { "InterPro-ID": "IPR003439", "InterPro-Name": "ABC_transporter-like_ATP-bd", "InterPro-Type": "DOMAIN", "Beg": 716, "End": 947 }, { "InterPro-ID": "IPR003439", "InterPro-Name": "ABC_transporter-like_ATP-bd", "InterPro-Type": "DOMAIN", "Beg": 454, "End": 672 }, { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 448, "End": 667 }, { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 676, "End": 991 }, { "InterPro-ID": "IPR000953", "InterPro-Name": "Chromo/chromo_shadow_dom", "InterPro-Type": "DOMAIN", "Beg": 828, "End": 883 }, { "InterPro-ID": "IPR050611", "InterPro-Name": "ABCF_EF3_subfamily", "InterPro-Type": "FAMILY", "Beg": 676, "End": 999 }, { "InterPro-ID": "IPR034085", "InterPro-Name": "TOG", "InterPro-Type": "DOMAIN", "Beg": 34, "End": 256 }, { "InterPro-ID": "IPR011989", "InterPro-Name": "ARM-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 42, "End": 355 }, { "InterPro-ID": "IPR003593", "InterPro-Name": "AAA+_ATPase", "InterPro-Type": "DOMAIN", "Beg": 725, "End": 1055 }, { "InterPro-ID": "IPR003593", "InterPro-Name": "AAA+_ATPase", "InterPro-Type": "DOMAIN", "Beg": 483, "End": 657 }, { "InterPro-ID": "IPR017871", "InterPro-Name": "ABC_transporter-like_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 919, "End": 933 }, { "InterPro-ID": "IPR017871", "InterPro-Name": "ABC_transporter-like_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 574, "End": 588 }, { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 701, "End": 997 }, { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 464, "End": 657 }, { "InterPro-ID": "IPR015688", "InterPro-Name": "eEF3_ABC2_chromodomain-like", "InterPro-Type": "DOMAIN", "Beg": 828, "End": 883 }, { "InterPro-ID": "IPR047038", "InterPro-Name": "eEF3_chromodomain-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 794, "End": 893 }, { "InterPro-ID": "IPR003439", "InterPro-Name": "ABC_transporter-like_ATP-bd", "InterPro-Type": "DOMAIN", "Beg": 474, "End": 602 }, { "InterPro-ID": "IPR016024", "InterPro-Name": "ARM-type_fold", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 72, "End": 1051 }, { "InterPro-ID": "IPR021133", "InterPro-Name": "HEAT_type_2", "InterPro-Type": "REPEAT", "Beg": 197, "End": 235 }, { "InterPro-ID": "IPR003439", "InterPro-Name": "ABC_transporter-like_ATP-bd", "InterPro-Type": "DOMAIN", "Beg": 699, "End": 1015 } ], "response#1": "MAPAPSAAGVPATVPAKAVKGAAGAAAKAGAAAEKKEASAETDALLSGDKDAAQELTNLVKIEGPAALANLGIEAVILKGLGDKKNATAREGACTLLANLCEQGVGHEVEPFIFENVLNSLVEAMGDKEKAVQKASLETLKAFVRVMSPWAAQQVLKVVLHQARTAGKWQVKTGCVALLEEMVTACPERMAALMPEIIPVMTEVIWDTKTDVQKASRAALTKLCALISNKDIERFIPALINSLIHPVEEVPKTIQLLSATTFVQEVDSATLALMVPLLSRGLNERPTATKRKVAVIIDNMTKLVDNERTVRPFLGKLLPGLIKIESTLADPEARSVVQRAIKTLREVGKVTGDGSDVKPLEDVDIKATQEQVNKALGEQSLQAQADLSSYLAVLVANLANARNFELTEWESTLIPYITLIKGSKPEQAKAVAKSLLTALAKSTGDTVEIFDDEEEGEDLCNCQFSLAYGAKILLNTATLRLKRGHKYGLCGRNGSGKSTLMRAITNGQVEGFPSPDEVRTWYVEHDLDGSEGLMTVLEFILADERLSMTRDEAVATLHEVGFDDARQNSPIAGLSGGWKMKVALARAILFKADILLLDEPTNHLDVVNVKWITDYLVNLKTATAIIVSHDSKFLNDVCTDILHLNRFKIKRYPGNLDAFVKRVPEARAYAELNTGEDYSFKLPDPPLLDGVKTKEKSLIKMKDVVFQYPGTPAPQLRGVSIQLSLASRVAILGPNGSGKSTLVKLIVGDTEPGSGEMWKHPNLVIGYVAQHAFHHIDQHLDKTPLDYMLWRYQTGEDLEEHMKANRALTAEEEAAKKQGEVFVIEGVKRLFDEIVGRKKLKNSFQYEVSFKNMSSADNQWVPRDDLINRGLERAVLAFDSKEAQRLGMNRPLVRKEIENHFEDFGLEREFTSHNTMRGLSGGQKVKVVLAAATWRRPHIIILDEPTNFLDRESLAALIKAIESFQGGVGIITHSKEFSEGTCKEIWAMNDGVLVASGHDWTESNSKGTKLEKKEEDDEYTDAMGNVHKKEKKAKKESASDRRKAKKDRMARKKAGTYDSADELEDL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more ABC_transporter-like_ATP-bd, ABC_transporter-like_ATP-bd, Chromo/chromo_shadow_dom, TOG, AAA+_ATPase, AAA+_ATPase, eEF3_ABC2_chromodomain-like, ABC_transporter-like_ATP-bd, ABC_transporter-like_ATP-bd that are essential for its biological function; 2. The protein should belong to ABCF_EF3_subfamily that shares evolutionary origin and functional similarity; 3. The protein should be classified within P-loop_NTPase, P-loop_NTPase, ARM-like, P-loop_NTPase, P-loop_NTPase, eEF3_chromodomain-like_sf, ARM-type_fold sharing conserved structural features; 4. The protein should include one or more HEAT_type_2 that provide structural or functional support; 5. The protein should contain ABC_transporter-like_CS, ABC_transporter-like_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MAPAPSAAGVPATVPAKAVKGAAGAAAKAGAAAEKKEASAETDALLSGDKDAAQELTNLVKIEGPAALANLGIEAVILKGLGDKKNATAREGACTLLANLCEQGVGHEVEPFIFENVLNSLVEAMGDKEKAVQKASLETLKAFVRVMSPWAAQQVLKVVLHQARTAGKWQVKTGCVALLEEMVTACPERMAALMPEIIPVMTEVIWDTKTDVQKASRAALTKLCALISNKDIERFIPALINSLIHPVEEVPKTIQLLSATTFVQEVDSATLALMVPLLSRGLNERPTATKRKVAVIIDNMTKLVDNERTVRPFLGKLLPGLIKIESTLADPEARSVVQRAIKTLREVGKVTGDGSDVKPLEDVDIKATQEQVNKALGEQSLQAQADLSSYLAVLVANLANARNFELTEWESTLIPYITLIKGSKPEQAKAVAKSLLTALAKSTGDTVEIFDDEEEGEDLCNCQFSLAYGAKILLNTATLRLKRGHKYGLCGRNGSGKSTLMRAITNGQVEGFPSPDEVRTWYVEHDLDGSEGLMTVLEFILADERLSMTRDEAVATLHEVGFDDARQNSPIAGLSGGWKMKVALARAILFKADILLLDEPTNHLDVVNVKWITDYLVNLKTATAIIVSHDSKFLNDVCTDILHLNRFKIKRYPGNLDAFVKRVPEARAYAELNTGEDYSFKLPDPPLLDGVKTKEKSLIKMKDVVFQYPGTPAPQLRGVSIQLSLASRVAILGPNGSGKSTLVKLIVGDTEPGSGEMWKHPNLVIGYVAQHAFHHIDQHLDKTPLDYMLWRYQTGEDLEEHMKANRALTAEEEAAKKQGEVFVIEGVKRLFDEIVGRKKLKNSFQYEVSFKNMSSADNQWVPRDDLINRGLERAVLAFDSKEAQRLGMNRPLVRKEIENHFEDFGLEREFTSHNTMRGLSGGQKVKVVLAAATWRRPHIIILDEPTNFLDRESLAALIKAIESFQGGVGIITHSKEFSEGTCKEIWAMNDGVLVASGHDWTESNSKGTKLEKKEEDDEYTDAMGNVHKKEKKAKKESASDRRKAKKDRMARKKAGTYDSADELEDL" }, { "InterPro": [ { "InterPro-ID": "IPR050611", "InterPro-Name": "ABCF_EF3_subfamily", "InterPro-Type": "FAMILY", "Beg": 476, "End": 575 }, { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 477, "End": 699 }, { "InterPro-ID": "IPR003439", "InterPro-Name": "ABC_transporter-like_ATP-bd", "InterPro-Type": "DOMAIN", "Beg": 730, "End": 1044 }, { "InterPro-ID": "IPR003439", "InterPro-Name": "ABC_transporter-like_ATP-bd", "InterPro-Type": "DOMAIN", "Beg": 747, "End": 854 }, { "InterPro-ID": "IPR047038", "InterPro-Name": "eEF3_chromodomain-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 825, "End": 922 }, { "InterPro-ID": "IPR003439", "InterPro-Name": "ABC_transporter-like_ATP-bd", "InterPro-Type": "DOMAIN", "Beg": 486, "End": 704 }, { "InterPro-ID": "IPR016197", "InterPro-Name": "Chromo-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 855, "End": 906 }, { "InterPro-ID": "IPR003439", "InterPro-Name": "ABC_transporter-like_ATP-bd", "InterPro-Type": "DOMAIN", "Beg": 503, "End": 634 }, { "InterPro-ID": "IPR000953", "InterPro-Name": "Chromo/chromo_shadow_dom", "InterPro-Type": "DOMAIN", "Beg": 857, "End": 912 }, { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 707, "End": 1020 }, { "InterPro-ID": "IPR021133", "InterPro-Name": "HEAT_type_2", "InterPro-Type": "REPEAT", "Beg": 223, "End": 261 }, { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 493, "End": 684 }, { "InterPro-ID": "IPR003593", "InterPro-Name": "AAA+_ATPase", "InterPro-Type": "DOMAIN", "Beg": 512, "End": 679 }, { "InterPro-ID": "IPR003593", "InterPro-Name": "AAA+_ATPase", "InterPro-Type": "DOMAIN", "Beg": 756, "End": 1021 }, { "InterPro-ID": "IPR015688", "InterPro-Name": "eEF3_ABC2_chromodomain-like", "InterPro-Type": "DOMAIN", "Beg": 857, "End": 912 }, { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 726, "End": 1027 }, { "InterPro-ID": "IPR017871", "InterPro-Name": "ABC_transporter-like_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 948, "End": 962 }, { "InterPro-ID": "IPR034085", "InterPro-Name": "TOG", "InterPro-Type": "DOMAIN", "Beg": 48, "End": 281 }, { "InterPro-ID": "IPR017871", "InterPro-Name": "ABC_transporter-like_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 606, "End": 620 }, { "InterPro-ID": "IPR016024", "InterPro-Name": "ARM-type_fold", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 64, "End": 998 }, { "InterPro-ID": "IPR003439", "InterPro-Name": "ABC_transporter-like_ATP-bd", "InterPro-Type": "DOMAIN", "Beg": 907, "End": 976 }, { "InterPro-ID": "IPR011989", "InterPro-Name": "ARM-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 53, "End": 374 } ], "response#1": "MPPKKSNARNASLLKEAVTNAGRSDTASTAREGSIAATFVSDSDSSTTASGPVDEKVAAVAELITTLTTNAASDKRQSAADDIAKFVEAEGVAQMVKTKILHGIATGLHNTKQPVAREGAITAIETLIKSPVSKQIEPYMITFIPVLLERLSDKAKTVCLAADSALKALITRLTPYATKQVLPLLLAGIEYSQKWQTKVGALELMQSLSKTAPRQMTTAVPDLVPPLSEVMHDTKAEAKNAGRQTMEAICELINNKDIEKFIPALIDTIANPEKVPDTVHLLGATTFVSEVLPPTLAIMVPLLSRGLNERQTAIKRKAAVIIINMCKLVEKPQIIAPFLPRLLPTLEKIQDDVADPECRQVCQNATKILTKVGIPAPGTVMDDSYEFKKLDDKALAYLKKAIGHQQITEIPEAYRPVLEYLEHIAAAMVADGNMDNDDWNGSIIPTLKAFIPTEGTVTNAVKEFRELSFGSNVKEAVAEEEEDDAEELCNCEFSLAYGARVLLNRTHLILKRGHRYGLTGANGSGKSTLMRAIANGQVEGFPPADQLKTVAVEHDLDGAHEHDNKEVQAFVLEDPVYAHLPKETVVNMLESVGFKGPMATRPVGQLSGGWRMKLALARAMLHNADILLLDEPTNHLDVINVAWLQDYLIGLKTVTSIIVSHDSSFLDIVCSDIIHLDNFKLKRYRGNLSKFVEAVPEAKAYYELGAAQQTFRFPEPGMLEGVKTKERAILKVQNAVFQYPGTDRRQLNGVTFQCSLGSRVAVVGPNGAGKSTLIKLLCGVIEPDNGVVWRHPNLRIAYVAQHAFEHIEKHTNLTPNQYIQWRYQTGEDREEMEKAARQISAEEEAAMKKVQVISGEKKVVDSVIGRRKLKNSYEYEVSWVGKLSNENSWLPRDTLIEMGFLKKVQEIDQAEAARQGLARPLTQKEIEKHLSDVGIDSEIGTHSHIRGLSGGQKVKVVIAGAMWQRPHLLVLDEPTNFLDRDSLGALKTAIDAYGGGVIMVTHSREFSEAICKEVWKVDNGELTPTGHNWVSGQGSGPRLEDKNKDEEVFDAFGNKIDVAKQKSKLSGKDLRKKRKEREARRKRGEEVSDDDE", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more ABC_transporter-like_ATP-bd, ABC_transporter-like_ATP-bd, ABC_transporter-like_ATP-bd, ABC_transporter-like_ATP-bd, Chromo/chromo_shadow_dom, AAA+_ATPase, AAA+_ATPase, eEF3_ABC2_chromodomain-like, TOG, ABC_transporter-like_ATP-bd that are essential for its biological function; 2. The protein should belong to ABCF_EF3_subfamily that shares evolutionary origin and functional similarity; 3. The protein should be classified within P-loop_NTPase, eEF3_chromodomain-like_sf, Chromo-like_dom_sf, P-loop_NTPase, P-loop_NTPase, P-loop_NTPase, ARM-type_fold, ARM-like sharing conserved structural features; 4. The protein should include one or more HEAT_type_2 that provide structural or functional support; 5. The protein should contain ABC_transporter-like_CS, ABC_transporter-like_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MPPKKSNARNASLLKEAVTNAGRSDTASTAREGSIAATFVSDSDSSTTASGPVDEKVAAVAELITTLTTNAASDKRQSAADDIAKFVEAEGVAQMVKTKILHGIATGLHNTKQPVAREGAITAIETLIKSPVSKQIEPYMITFIPVLLERLSDKAKTVCLAADSALKALITRLTPYATKQVLPLLLAGIEYSQKWQTKVGALELMQSLSKTAPRQMTTAVPDLVPPLSEVMHDTKAEAKNAGRQTMEAICELINNKDIEKFIPALIDTIANPEKVPDTVHLLGATTFVSEVLPPTLAIMVPLLSRGLNERQTAIKRKAAVIIINMCKLVEKPQIIAPFLPRLLPTLEKIQDDVADPECRQVCQNATKILTKVGIPAPGTVMDDSYEFKKLDDKALAYLKKAIGHQQITEIPEAYRPVLEYLEHIAAAMVADGNMDNDDWNGSIIPTLKAFIPTEGTVTNAVKEFRELSFGSNVKEAVAEEEEDDAEELCNCEFSLAYGARVLLNRTHLILKRGHRYGLTGANGSGKSTLMRAIANGQVEGFPPADQLKTVAVEHDLDGAHEHDNKEVQAFVLEDPVYAHLPKETVVNMLESVGFKGPMATRPVGQLSGGWRMKLALARAMLHNADILLLDEPTNHLDVINVAWLQDYLIGLKTVTSIIVSHDSSFLDIVCSDIIHLDNFKLKRYRGNLSKFVEAVPEAKAYYELGAAQQTFRFPEPGMLEGVKTKERAILKVQNAVFQYPGTDRRQLNGVTFQCSLGSRVAVVGPNGAGKSTLIKLLCGVIEPDNGVVWRHPNLRIAYVAQHAFEHIEKHTNLTPNQYIQWRYQTGEDREEMEKAARQISAEEEAAMKKVQVISGEKKVVDSVIGRRKLKNSYEYEVSWVGKLSNENSWLPRDTLIEMGFLKKVQEIDQAEAARQGLARPLTQKEIEKHLSDVGIDSEIGTHSHIRGLSGGQKVKVVIAGAMWQRPHLLVLDEPTNFLDRDSLGALKTAIDAYGGGVIMVTHSREFSEAICKEVWKVDNGELTPTGHNWVSGQGSGPRLEDKNKDEEVFDAFGNKIDVAKQKSKLSGKDLRKKRKEREARRKRGEEVSDDDE" }, { "InterPro": [ { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 310, "End": 633 }, { "InterPro-ID": "IPR051650", "InterPro-Name": "SL_signaling_regulator", "InterPro-Type": "FAMILY", "Beg": 8, "End": 655 }, { "InterPro-ID": "IPR003959", "InterPro-Name": "ATPase_AAA_core", "InterPro-Type": "DOMAIN", "Beg": 415, "End": 487 }, { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 281, "End": 506 } ], "response#1": "MISEIGKAAVAEMGILLARFREDHNKLWLIGTATCETYLRCQVYHSTMENDWDLQAVPIASRSPHPGIFPRLGNERILGSSMEPLNPLKSFTGSVPVLSSRGPGNLNPRLRKSCCPQCTEKFEQELAKLVSEFANQSSEDKSESPRPQLPQWLQNAKLNNDSKVTALSQSKDQALLQQKTQELQKKWNDTCLQLHPNFQQNIGPERTVSPALCMPGLYNPNLLLRQPLQPKLQPSKNLGVSLQLNTTQMASKPQEKAASPPGSPVRTDLVLGPKQTETTPEKTLEDQAKDFLSRISSVPQNKFLDKFASALDADTFKRLLKGLMEKAWWQQDAASSVASAVSRCRLGNGRQRGGAPKGDIWLLFSGPDRFAKRKMASVLAEQFCGNSPIMICLGSRRDDEESDLGFRGKTALDRIAEAVRRNPVSVIMLEDIDEANVLIRGSIKRAMDRGKLTDSHGREISLGNVIFILTGNWSTMSPESYRNEYLMEEKKLVSLASSNWQLRLSLGEKSAKRRASWLHDEDRPTRPRKELNLGLAFDLNEAADVEDYRTDGSHNSSDLTVDHEEEPGLENRRFAIASVPHDLVSSVDDTIPFKLIEFSFARREIKKTISKKFSMVVDDKVSIEVEDDIVDRILGGLWRGQTSLEQWVEKVLGPSFDQLQPRLSTLDENAVVRLQLELYTALKGQSNGECLPSKVTIVADGQVMSTTS", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more ATPase_AAA_core that are essential for its biological function; 2. The protein should belong to SL_signaling_regulator that shares evolutionary origin and functional similarity; 3. The protein should be classified within P-loop_NTPase, P-loop_NTPase sharing conserved structural features. The designed protein sequence is ", "reference": "MISEIGKAAVAEMGILLARFREDHNKLWLIGTATCETYLRCQVYHSTMENDWDLQAVPIASRSPHPGIFPRLGNERILGSSMEPLNPLKSFTGSVPVLSSRGPGNLNPRLRKSCCPQCTEKFEQELAKLVSEFANQSSEDKSESPRPQLPQWLQNAKLNNDSKVTALSQSKDQALLQQKTQELQKKWNDTCLQLHPNFQQNIGPERTVSPALCMPGLYNPNLLLRQPLQPKLQPSKNLGVSLQLNTTQMASKPQEKAASPPGSPVRTDLVLGPKQTETTPEKTLEDQAKDFLSRISSVPQNKFLDKFASALDADTFKRLLKGLMEKAWWQQDAASSVASAVSRCRLGNGRQRGGAPKGDIWLLFSGPDRFAKRKMASVLAEQFCGNSPIMICLGSRRDDEESDLGFRGKTALDRIAEAVRRNPVSVIMLEDIDEANVLIRGSIKRAMDRGKLTDSHGREISLGNVIFILTGNWSTMSPESYRNEYLMEEKKLVSLASSNWQLRLSLGEKSAKRRASWLHDEDRPTRPRKELNLGLAFDLNEAADVEDYRTDGSHNSSDLTVDHEEEPGLENRRFAIASVPHDLVSSVDDTIPFKLIEFSFARREIKKTISKKFSMVVDDKVSIEVEDDIVDRILGGLWRGQTSLEQWVEKVLGPSFDQLQPRLSTLDENAVVRLQLELYTALKGQSNGECLPSKVTIVADGQVMSTTS" }, { "InterPro": [ { "InterPro-ID": "IPR020803", "InterPro-Name": "MeTfrase_dom", "InterPro-Type": "DOMAIN", "Beg": 21, "End": 264 }, { "InterPro-ID": "IPR013216", "InterPro-Name": "Methyltransf_11", "InterPro-Type": "DOMAIN", "Beg": 67, "End": 165 }, { "InterPro-ID": "IPR029063", "InterPro-Name": "SAM-dependent_MTases_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 12, "End": 221 }, { "InterPro-ID": "IPR029063", "InterPro-Name": "SAM-dependent_MTases_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 2, "End": 264 }, { "InterPro-ID": "IPR050447", "InterPro-Name": "Erg6_SMT_methyltransf", "InterPro-Type": "FAMILY", "Beg": 14, "End": 219 } ], "response#1": "MTLQPTAADVGAMYDQYTSLLTDVMAGFIHVGYWEDPSSEETMEVATERMTREVGARLSSSAGQHILDVGCGTGKSAVQIANTHGVQITGITVSKSQIEEAQALYGSAVQAGQVSYQFANAMDLPFADASFDGAYAIESLVHMDDRRTALQNIARVLRPGSRLAIADLCLDAHCPNPEALARFHELFQVPPMSSGEELQELLRETGFRVLEFTDIRDNVRPVCKFLEKKALSLEGEVGEKLLEIATSMATLKELGYAFITAERI", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more MeTfrase_dom, Methyltransf_11 that are essential for its biological function; 2. The protein should belong to Erg6_SMT_methyltransf that shares evolutionary origin and functional similarity; 3. The protein should be classified within SAM-dependent_MTases_sf, SAM-dependent_MTases_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MTLQPTAADVGAMYDQYTSLLTDVMAGFIHVGYWEDPSSEETMEVATERMTREVGARLSSSAGQHILDVGCGTGKSAVQIANTHGVQITGITVSKSQIEEAQALYGSAVQAGQVSYQFANAMDLPFADASFDGAYAIESLVHMDDRRTALQNIARVLRPGSRLAIADLCLDAHCPNPEALARFHELFQVPPMSSGEELQELLRETGFRVLEFTDIRDNVRPVCKFLEKKALSLEGEVGEKLLEIATSMATLKELGYAFITAERI" }, { "InterPro": [ { "InterPro-ID": "IPR029058", "InterPro-Name": "AB_hydrolase_fold", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 10, "End": 240 }, { "InterPro-ID": "IPR029058", "InterPro-Name": "AB_hydrolase_fold", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1, "End": 249 }, { "InterPro-ID": "IPR000073", "InterPro-Name": "AB_hydrolase_1", "InterPro-Type": "DOMAIN", "Beg": 20, "End": 227 } ], "response#1": "MSIVKEAHNVKVLGSGEKTIVLGHGFGTDQSVWKHLVPYLIDEYRVVLYDNMGAGPTNPDYFDFHRYSSLEGYAYDLLSILEELEIKCCIYLGHSSSAMTGVVASIFRPDLFSKLILVSASPRFLNTDDYYGGFELEEIDQLCQAMESNYKAWIAGFAPLVVGGDMDSVAVQEFSRTLFNMRPDIALSVFRTVFTFDLRHFLSQVTVPCHIIQSSLDVAVPVAVSQYLHQNLGGMSIVEIISTEGADCFGSYRRGSEMETKRGSDDAVTIALR", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more AB_hydrolase_1 that are essential for its biological function; 2. The protein should be classified within AB_hydrolase_fold, AB_hydrolase_fold sharing conserved structural features. The designed protein sequence is ", "reference": "MSIVKEAHNVKVLGSGEKTIVLGHGFGTDQSVWKHLVPYLIDEYRVVLYDNMGAGPTNPDYFDFHRYSSLEGYAYDLLSILEELEIKCCIYLGHSSSAMTGVVASIFRPDLFSKLILVSASPRFLNTDDYYGGFELEEIDQLCQAMESNYKAWIAGFAPLVVGGDMDSVAVQEFSRTLFNMRPDIALSVFRTVFTFDLRHFLSQVTVPCHIIQSSLDVAVPVAVSQYLHQNLGGMSIVEIISTEGADCFGSYRRGSEMETKRGSDDAVTIALR" }, { "InterPro": [ { "InterPro-ID": "IPR032345", "InterPro-Name": "PnbB", "InterPro-Type": "FAMILY", "Beg": 12, "End": 162 } ], "response#1": "MSTPQDLIDASIPFLNELKNRTAGEDLEKWLNDAYGPGSEFYERVAGLVKDGVRDGWAANIEVDGPRYRRSRLAEPCEELNYFSITAVYMDSVEPYRGQYHQHPYGELNMVVPLNEGAELAGPRGWCGGGWTAPDPASHHYPEVRGGAIIALFYLPAGRISYDITPPAE", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to PnbB that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MSTPQDLIDASIPFLNELKNRTAGEDLEKWLNDAYGPGSEFYERVAGLVKDGVRDGWAANIEVDGPRYRRSRLAEPCEELNYFSITAVYMDSVEPYRGQYHQHPYGELNMVVPLNEGAELAGPRGWCGGGWTAPDPASHHYPEVRGGAIIALFYLPAGRISYDITPPAE" }, { "InterPro": [ { "InterPro-ID": "IPR006656", "InterPro-Name": "Mopterin_OxRdtase", "InterPro-Type": "DOMAIN", "Beg": 333, "End": 709 }, { "InterPro-ID": "IPR006963", "InterPro-Name": "Mopterin_OxRdtase_4Fe-4S_dom", "InterPro-Type": "DOMAIN", "Beg": 61, "End": 127 }, { "InterPro-ID": "IPR050612", "InterPro-Name": "Prok_Mopterin_Oxidored", "InterPro-Type": "FAMILY", "Beg": 9, "End": 1048 }, { "InterPro-ID": "IPR006657", "InterPro-Name": "MoPterin_dinucl-bd_dom", "InterPro-Type": "DOMAIN", "Beg": 892, "End": 986 }, { "InterPro-ID": "IPR006963", "InterPro-Name": "Mopterin_OxRdtase_4Fe-4S_dom", "InterPro-Type": "DOMAIN", "Beg": 56, "End": 129 }, { "InterPro-ID": "IPR006963", "InterPro-Name": "Mopterin_OxRdtase_4Fe-4S_dom", "InterPro-Type": "DOMAIN", "Beg": 56, "End": 127 }, { "InterPro-ID": "IPR009010", "InterPro-Name": "Asp_de-COase-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 886, "End": 1047 }, { "InterPro-ID": "IPR019546", "InterPro-Name": "TAT_signal_bac_arc", "InterPro-Type": "CONSERVED_SITE", "Beg": 9, "End": 33 }, { "InterPro-ID": "IPR006311", "InterPro-Name": "TAT_signal", "InterPro-Type": "CONSERVED_SITE", "Beg": 1, "End": 39 } ], "response#1": "MENQHQKFISRRNFIKTSALLGGTAFLGTGLPNIKKTYSKELDYVGNFEYPLAKPENILYSACLQCTVACSIKVKINNGVCMKIDGNPYSAMNLGENLPYDLSPKEAVSIDGKLCPKGQAGIQHAYDPYRLRKVIKRDGPRGSGKWKTIPYDQAIDEIVNGGNIFKDIGENQNVEGLKDIFVLKDPKVAKAMADDVTKIRKKEMTVDEFKAKHKDNLDVLIDPNHPDLGPKNNQFLFQVGRIHNGRIEFTKRFVNDSFGSVNWIEKTTLCGQTSNKAWVHSTREYLEGKWTGGIKSPRPDHRNTEFLLVFGSIVFEANYGPVQETEPITEGLESGRLKIAVVDPRLTKVASKAWKWVPIKPGNDAAFALGMIRWIIENERYDTKFLQNATRLAATNSDEPSYSNATYLVKVEKDGRAAKHLRANEIGIGTEKEFVVISNGKPAAVDPENSNLAIQGELFVDTNLEGIKVKSPLQLIKEEAYSKELAEWAELSGAKQKDIEDISKEFTSHGKKAAVEFYRGAIKHTNGWYNGQALIVLNHLIGNMNWQGGISNTGGGWSYIGDKEGQPYPMANLHPNKLSKFGVPITKEGWKYEESTLFEGYPAKRPWYPFSGNVAQETWPSISDGYPYKIKAALISSHSPMYSLPGGHVQLKTLLDTEKVPLLIASDIVIGDSSQYVDYIFPDLTYLERWATPGQSHHIRVKVNQVRQPVIAPLTENATVFGEEVPISLEALMMSISEKVGLSGFGKDAFGPGKDLNRMEDFYLKLVANIASGNKQGELVKAADSEEMELFKSSHRHLPKTVYDIEKWQQTLTSDEWKRVVYVLNRGGRFASSDDAYEGSFIKKKIPGLARLYLEEIADSRNSISGNYFTGYPKYLPIMDMAENLINDEGEFHLITNKEVFGTQSRTITNYWAQLALQPENFVVLNSVDAKKLKVDNGDKVLVTSTSNPKGEHLIAADESRPTIGKVKIVEGIRPGVVAISTHYGHWGYGARDIQIDGEVVKGEEVRGLGIHPNPLFRLDDNLRGTTLSDPIGGSASYYDTRVNIQRV", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Mopterin_OxRdtase, Mopterin_OxRdtase_4Fe-4S_dom, MoPterin_dinucl-bd_dom, Mopterin_OxRdtase_4Fe-4S_dom, Mopterin_OxRdtase_4Fe-4S_dom that are essential for its biological function; 2. The protein should belong to Prok_Mopterin_Oxidored that shares evolutionary origin and functional similarity; 3. The protein should be classified within Asp_de-COase-like_dom_sf sharing conserved structural features; 4. The protein should contain TAT_signal_bac_arc, TAT_signal that is preserved across related proteins. The designed protein sequence is ", "reference": "MENQHQKFISRRNFIKTSALLGGTAFLGTGLPNIKKTYSKELDYVGNFEYPLAKPENILYSACLQCTVACSIKVKINNGVCMKIDGNPYSAMNLGENLPYDLSPKEAVSIDGKLCPKGQAGIQHAYDPYRLRKVIKRDGPRGSGKWKTIPYDQAIDEIVNGGNIFKDIGENQNVEGLKDIFVLKDPKVAKAMADDVTKIRKKEMTVDEFKAKHKDNLDVLIDPNHPDLGPKNNQFLFQVGRIHNGRIEFTKRFVNDSFGSVNWIEKTTLCGQTSNKAWVHSTREYLEGKWTGGIKSPRPDHRNTEFLLVFGSIVFEANYGPVQETEPITEGLESGRLKIAVVDPRLTKVASKAWKWVPIKPGNDAAFALGMIRWIIENERYDTKFLQNATRLAATNSDEPSYSNATYLVKVEKDGRAAKHLRANEIGIGTEKEFVVISNGKPAAVDPENSNLAIQGELFVDTNLEGIKVKSPLQLIKEEAYSKELAEWAELSGAKQKDIEDISKEFTSHGKKAAVEFYRGAIKHTNGWYNGQALIVLNHLIGNMNWQGGISNTGGGWSYIGDKEGQPYPMANLHPNKLSKFGVPITKEGWKYEESTLFEGYPAKRPWYPFSGNVAQETWPSISDGYPYKIKAALISSHSPMYSLPGGHVQLKTLLDTEKVPLLIASDIVIGDSSQYVDYIFPDLTYLERWATPGQSHHIRVKVNQVRQPVIAPLTENATVFGEEVPISLEALMMSISEKVGLSGFGKDAFGPGKDLNRMEDFYLKLVANIASGNKQGELVKAADSEEMELFKSSHRHLPKTVYDIEKWQQTLTSDEWKRVVYVLNRGGRFASSDDAYEGSFIKKKIPGLARLYLEEIADSRNSISGNYFTGYPKYLPIMDMAENLINDEGEFHLITNKEVFGTQSRTITNYWAQLALQPENFVVLNSVDAKKLKVDNGDKVLVTSTSNPKGEHLIAADESRPTIGKVKIVEGIRPGVVAISTHYGHWGYGARDIQIDGEVVKGEEVRGLGIHPNPLFRLDDNLRGTTLSDPIGGSASYYDTRVNIQRV" }, { "InterPro": [ { "InterPro-ID": "IPR029277", "InterPro-Name": "SVWC_dom", "InterPro-Type": "DOMAIN", "Beg": 37, "End": 96 } ], "response#1": "MYRETFVFCVLLAVVSANVEMRDLEEKPEKYKGVNCCYVSAIQECIPVGETRPFKHECKGWTCNKDNLLEVSCGKVLVEHYVEDKTAPYPHCCPVAKA", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more SVWC_dom that are essential for its biological function. The designed protein sequence is ", "reference": "MYRETFVFCVLLAVVSANVEMRDLEEKPEKYKGVNCCYVSAIQECIPVGETRPFKHECKGWTCNKDNLLEVSCGKVLVEHYVEDKTAPYPHCCPVAKA" }, { "InterPro": [ { "InterPro-ID": "IPR002347", "InterPro-Name": "SDR_fam", "InterPro-Type": "FAMILY", "Beg": 237, "End": 256 }, { "InterPro-ID": "IPR002347", "InterPro-Name": "SDR_fam", "InterPro-Type": "FAMILY", "Beg": 52, "End": 69 }, { "InterPro-ID": "IPR002347", "InterPro-Name": "SDR_fam", "InterPro-Type": "FAMILY", "Beg": 129, "End": 140 }, { "InterPro-ID": "IPR036291", "InterPro-Name": "NAD(P)-bd_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 44, "End": 317 }, { "InterPro-ID": "IPR002347", "InterPro-Name": "SDR_fam", "InterPro-Type": "FAMILY", "Beg": 51, "End": 175 } ], "response#1": "MTGFLPEPLRMLVTSPALLDFTSDGPLPYALRQKFTGKPPPVTSNLSLASQTVLVTGATSGVGLEAARQLAQLGPRLLILGVRNASKAEQIKSELERDTPNLTVQVAELDLESLLSVDRFVDELSANSIRLDLALLNAGFFAHDDRITDDGYSPLFQVNFLSTAYLTLKLLPLLHTTAPPHPPGTTTPPGPRLVLVTSEAHAWTTFPDVPRPTENRTQPILSVFQDKNTLGSADDQYARAKLLLALFGKELSRRLTAAENDTTVVITTPGFCASNFFPDGMMTRLIQLTSARSVQQGGALHVFAATAPGPEIHGAYLRDGKPTGLSKFAQGPQGQILQERLWGEMEEFFMQRGGSPLGM", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to SDR_fam, SDR_fam, SDR_fam, SDR_fam that shares evolutionary origin and functional similarity; 2. The protein should be classified within NAD(P)-bd_dom_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MTGFLPEPLRMLVTSPALLDFTSDGPLPYALRQKFTGKPPPVTSNLSLASQTVLVTGATSGVGLEAARQLAQLGPRLLILGVRNASKAEQIKSELERDTPNLTVQVAELDLESLLSVDRFVDELSANSIRLDLALLNAGFFAHDDRITDDGYSPLFQVNFLSTAYLTLKLLPLLHTTAPPHPPGTTTPPGPRLVLVTSEAHAWTTFPDVPRPTENRTQPILSVFQDKNTLGSADDQYARAKLLLALFGKELSRRLTAAENDTTVVITTPGFCASNFFPDGMMTRLIQLTSARSVQQGGALHVFAATAPGPEIHGAYLRDGKPTGLSKFAQGPQGQILQERLWGEMEEFFMQRGGSPLGM" }, { "InterPro": [ { "InterPro-ID": "IPR013216", "InterPro-Name": "Methyltransf_11", "InterPro-Type": "DOMAIN", "Beg": 70, "End": 167 }, { "InterPro-ID": "IPR029063", "InterPro-Name": "SAM-dependent_MTases_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 12, "End": 226 }, { "InterPro-ID": "IPR029063", "InterPro-Name": "SAM-dependent_MTases_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1, "End": 267 }, { "InterPro-ID": "IPR050447", "InterPro-Name": "Erg6_SMT_methyltransf", "InterPro-Type": "FAMILY", "Beg": 13, "End": 221 }, { "InterPro-ID": "IPR020803", "InterPro-Name": "MeTfrase_dom", "InterPro-Type": "DOMAIN", "Beg": 23, "End": 266 } ], "response#1": "MSKIAQPTATDVGAMYDNHTDLMTDIMAGFIHVGYWEDPENPTETIELATERMTLEVLNRLRPSPGQHILDVGCGTGKTAASIATTHDVSITGITVSNHQIEVARKTYEALVETGKLNFQYADAMQLPLANASFDGAYAIESIVHMNDRRAALSNIARVLRPGSRLSIADLVLDDGCPDPDAIANWHELFQVPALISADKLKELLTETGFRVLECVDIRQHIRPICGVMDKKGLQVGGEVGKTLRGVAASLHGLEELGYILLVAERV", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Methyltransf_11, MeTfrase_dom that are essential for its biological function; 2. The protein should belong to Erg6_SMT_methyltransf that shares evolutionary origin and functional similarity; 3. The protein should be classified within SAM-dependent_MTases_sf, SAM-dependent_MTases_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MSKIAQPTATDVGAMYDNHTDLMTDIMAGFIHVGYWEDPENPTETIELATERMTLEVLNRLRPSPGQHILDVGCGTGKTAASIATTHDVSITGITVSNHQIEVARKTYEALVETGKLNFQYADAMQLPLANASFDGAYAIESIVHMNDRRAALSNIARVLRPGSRLSIADLVLDDGCPDPDAIANWHELFQVPALISADKLKELLTETGFRVLECVDIRQHIRPICGVMDKKGLQVGGEVGKTLRGVAASLHGLEELGYILLVAERV" }, { "InterPro": [ { "InterPro-ID": "IPR020843", "InterPro-Name": "PKS_ER", "InterPro-Type": "DOMAIN", "Beg": 10, "End": 355 }, { "InterPro-ID": "IPR013154", "InterPro-Name": "ADH-like_N", "InterPro-Type": "DOMAIN", "Beg": 25, "End": 113 }, { "InterPro-ID": "IPR036291", "InterPro-Name": "NAD(P)-bd_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 115, "End": 322 }, { "InterPro-ID": "IPR047122", "InterPro-Name": "Trans-enoyl_RdTase-like", "InterPro-Type": "FAMILY", "Beg": 1, "End": 357 }, { "InterPro-ID": "IPR011032", "InterPro-Name": "GroES-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1, "End": 135 } ], "response#1": "MQAIISTAPGQAALVHDRPLPTIRDGYLLVKTKAVALNPTDWKHIEVTQKPGILFGCDYAGIVEQVGPGVQSGFQPGDRVAGFVHGGNSKEPQDGAFAEYIVAKADLQIHIPEHMSFEEAATLGVGITAVGQGLYQTLSLPFPSPSSIHEDGAEKPANPATQPILIYGASTASGVLGIQFAKLSGFAPLAVCSPDHFDLAERLGAVAVFDYADGEDAVEEIQDYVRGMGQPLLKAWDTISIPSSARFCGDALSSGNGPQYASLLSMTCPRPDVTSTTTMAYTVFGEDWGMGTAHFPASGVDAELGRRWWALVQQLLNEGRIQTHRIIAGEGGLDGVLGGLQQLRDSQVRGGKLVFRV", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more PKS_ER, ADH-like_N that are essential for its biological function; 2. The protein should belong to Trans-enoyl_RdTase-like that shares evolutionary origin and functional similarity; 3. The protein should be classified within NAD(P)-bd_dom_sf, GroES-like_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MQAIISTAPGQAALVHDRPLPTIRDGYLLVKTKAVALNPTDWKHIEVTQKPGILFGCDYAGIVEQVGPGVQSGFQPGDRVAGFVHGGNSKEPQDGAFAEYIVAKADLQIHIPEHMSFEEAATLGVGITAVGQGLYQTLSLPFPSPSSIHEDGAEKPANPATQPILIYGASTASGVLGIQFAKLSGFAPLAVCSPDHFDLAERLGAVAVFDYADGEDAVEEIQDYVRGMGQPLLKAWDTISIPSSARFCGDALSSGNGPQYASLLSMTCPRPDVTSTTTMAYTVFGEDWGMGTAHFPASGVDAELGRRWWALVQQLLNEGRIQTHRIIAGEGGLDGVLGGLQQLRDSQVRGGKLVFRV" }, { "InterPro": [ { "InterPro-ID": "IPR002350", "InterPro-Name": "Kazal_dom", "InterPro-Type": "DOMAIN", "Beg": 28, "End": 74 }, { "InterPro-ID": "IPR036058", "InterPro-Name": "Kazal_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 28, "End": 76 } ], "response#1": "MNSKFVLIVVFLAVVSICFANEVWDPEKCGCPPFDKVENAVCTKDRATYDNRCQFDCHAKFLSKSGKTLEESPCIESADPK", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Kazal_dom that are essential for its biological function; 2. The protein should be classified within Kazal_dom_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MNSKFVLIVVFLAVVSICFANEVWDPEKCGCPPFDKVENAVCTKDRATYDNRCQFDCHAKFLSKSGKTLEESPCIESADPK" }, { "InterPro": [ { "InterPro-ID": "IPR000776", "InterPro-Name": "Fusion_F0_Paramyxovir", "InterPro-Type": "FAMILY", "Beg": 22, "End": 502 } ], "response#1": "MKAFPVICLGFAIFSSSICVNINILQQIGYIKQQVWQLSYYSQSSSSYVVVKLLPNIQPTDNSCEFKSVTQYNKTLSNLLLPIAENINNIASPSPGSRRHKRFAGIAIGIAALGVATAAQVTAAVSLVQAQTNARAIAAMKNSIQATNRAVFEVKEGTQQLAIAVQAIQDHINTIMNTQLNNMSCQILDNQLATSLGLYLTELTTVFQPQLINPALSPISIQALRSLLGSMTPAVVQATLSTSISAAEILSAGLMEGQIVSVLLDEMQMIVKINIPTIVTQSNALVIDFHSISSFINNQESIIQLPDRILEIGNEQWRYPAKNCKLTRHHIFCQYNEAERLSLETKLCLAGNISACVFSPIAGSYMRRFVALDGTIVANCRSLTCLCKSPSYPIYQPDHHAVTTIDLTSCQTLSLDGLDFSIVSLSNITYAENLTISLSQTINTQPIDISTELSKVNASLQNAVKYIKESNHQLQSVSVSSKIGAIIVAALVLSILSIIISLLFCCWAYIATKEIRRINFKTNHINTISSSVDDLIRY", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Fusion_F0_Paramyxovir that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MKAFPVICLGFAIFSSSICVNINILQQIGYIKQQVWQLSYYSQSSSSYVVVKLLPNIQPTDNSCEFKSVTQYNKTLSNLLLPIAENINNIASPSPGSRRHKRFAGIAIGIAALGVATAAQVTAAVSLVQAQTNARAIAAMKNSIQATNRAVFEVKEGTQQLAIAVQAIQDHINTIMNTQLNNMSCQILDNQLATSLGLYLTELTTVFQPQLINPALSPISIQALRSLLGSMTPAVVQATLSTSISAAEILSAGLMEGQIVSVLLDEMQMIVKINIPTIVTQSNALVIDFHSISSFINNQESIIQLPDRILEIGNEQWRYPAKNCKLTRHHIFCQYNEAERLSLETKLCLAGNISACVFSPIAGSYMRRFVALDGTIVANCRSLTCLCKSPSYPIYQPDHHAVTTIDLTSCQTLSLDGLDFSIVSLSNITYAENLTISLSQTINTQPIDISTELSKVNASLQNAVKYIKESNHQLQSVSVSSKIGAIIVAALVLSILSIIISLLFCCWAYIATKEIRRINFKTNHINTISSSVDDLIRY" }, { "InterPro": [ { "InterPro-ID": "IPR042539", "InterPro-Name": "Matrix_C", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 191, "End": 356 }, { "InterPro-ID": "IPR055413", "InterPro-Name": "Matrix_Paramyxo_C", "InterPro-Type": "DOMAIN", "Beg": 186, "End": 348 }, { "InterPro-ID": "IPR000982", "InterPro-Name": "Matrix_Paramyxo_N", "InterPro-Type": "DOMAIN", "Beg": 10, "End": 183 }, { "InterPro-ID": "IPR042540", "InterPro-Name": "Matrix_N", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 2, "End": 190 } ], "response#1": "MAGSQIKIPLPKPPDSDSQRLNAFPVIMAQEGKGRLLRQIRLRKILSGDPSDQQITFVNTYGFIRATPETSEFISESSQQKVTPVVTACMLSFGAGPVLEDPQHMLKALDQTDIRVRKTASDKEQILFEINRIPNLFRHYQISADHLIQASSDKYVKSPAKLIAGVNYIYCVTFLSVTVCSASLKFRVARPLLAARSRLVRAVQMEILLRVTCKKDSQMAKSMLNDPDGEGCIASVWFHLCNLCKGRNKLRSYDENYFASKCRKMNLTVSIGDMWGPTILVHAGGHIPTTAKPFFNSRGWVCHPIHQSSPSLAKTLWSSGCEIKAASAILQGSDYASLAKTDDIIYSKIKVDKDAANYKGVSWSPFRKSASMRNL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Matrix_Paramyxo_C, Matrix_Paramyxo_N that are essential for its biological function; 2. The protein should be classified within Matrix_C, Matrix_N sharing conserved structural features. The designed protein sequence is ", "reference": "MAGSQIKIPLPKPPDSDSQRLNAFPVIMAQEGKGRLLRQIRLRKILSGDPSDQQITFVNTYGFIRATPETSEFISESSQQKVTPVVTACMLSFGAGPVLEDPQHMLKALDQTDIRVRKTASDKEQILFEINRIPNLFRHYQISADHLIQASSDKYVKSPAKLIAGVNYIYCVTFLSVTVCSASLKFRVARPLLAARSRLVRAVQMEILLRVTCKKDSQMAKSMLNDPDGEGCIASVWFHLCNLCKGRNKLRSYDENYFASKCRKMNLTVSIGDMWGPTILVHAGGHIPTTAKPFFNSRGWVCHPIHQSSPSLAKTLWSSGCEIKAASAILQGSDYASLAKTDDIIYSKIKVDKDAANYKGVSWSPFRKSASMRNL" }, { "InterPro": [ { "InterPro-ID": "IPR003614", "InterPro-Name": "Scorpion_toxin-like", "InterPro-Type": "DOMAIN", "Beg": 1, "End": 51 }, { "InterPro-ID": "IPR044062", "InterPro-Name": "LCN-type_CS_alpha_beta_dom", "InterPro-Type": "DOMAIN", "Beg": 1, "End": 66 }, { "InterPro-ID": "IPR036574", "InterPro-Name": "Scorpion_toxin-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1, "End": 66 }, { "InterPro-ID": "IPR018218", "InterPro-Name": "Scorpion_toxinL", "InterPro-Type": "FAMILY", "Beg": 45, "End": 58 }, { "InterPro-ID": "IPR018218", "InterPro-Name": "Scorpion_toxinL", "InterPro-Type": "FAMILY", "Beg": 11, "End": 18 }, { "InterPro-ID": "IPR018218", "InterPro-Name": "Scorpion_toxinL", "InterPro-Type": "FAMILY", "Beg": 22, "End": 29 }, { "InterPro-ID": "IPR018218", "InterPro-Name": "Scorpion_toxinL", "InterPro-Type": "FAMILY", "Beg": 35, "End": 45 }, { "InterPro-ID": "IPR002061", "InterPro-Name": "Scorpion_toxinL/defensin", "InterPro-Type": "FAMILY", "Beg": 1, "End": 52 }, { "InterPro-ID": "IPR036574", "InterPro-Name": "Scorpion_toxin-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1, "End": 65 } ], "response#1": "KEGYIVDYHTGCKYTCAKLGDNDYCVRECRLRYYQSAHGYCYAFACWCTHLYEAAVVWPLPNKRCK", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Scorpion_toxin-like, LCN-type_CS_alpha_beta_dom that are essential for its biological function; 2. The protein should belong to Scorpion_toxinL, Scorpion_toxinL, Scorpion_toxinL, Scorpion_toxinL, Scorpion_toxinL/defensin that shares evolutionary origin and functional similarity; 3. The protein should be classified within Scorpion_toxin-like_sf, Scorpion_toxin-like_sf sharing conserved structural features. The designed protein sequence is ", "reference": "KEGYIVDYHTGCKYTCAKLGDNDYCVRECRLRYYQSAHGYCYAFACWCTHLYEAAVVWPLPNKRCK" }, { "InterPro": [ { "InterPro-ID": "IPR027844", "InterPro-Name": "INTS15", "InterPro-Type": "FAMILY", "Beg": 16, "End": 360 }, { "InterPro-ID": "IPR027844", "InterPro-Name": "INTS15", "InterPro-Type": "FAMILY", "Beg": 15, "End": 372 } ], "response#1": "MSMSIDSNKLLLRKGDMKLDNYPTCAVEALTRLETLIASRNKQNMVMQIISEFIFLERTPKDGDVRKSQALPISQMNLFQEFQLIIALIEYFSRPGRDATRNAIFLSLFGSHLTPQRSKLLSRLISTAVSGSVAPLLSSAGTWMQQVGCKTPLSLEVAQNIVSDFISYSRKTPEQLKQLPMVGPHFAANFMVAVADLYLNEQRSPTLNPPPDALLDTITEWMMENPTLCQASQQPLVLPAGAIAMPFTTPLAGLLRWVVLAPLVSNRSAYSNLHLSLLRALQQLVSSGESTALPSQDLMQIVKSLQSYCARLAESKTDPQADAAYQKCMERFAQAVQIALSSNCITNQIQLLCLLESLPPHKLMKIVIEAHKK", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to INTS15, INTS15 that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MSMSIDSNKLLLRKGDMKLDNYPTCAVEALTRLETLIASRNKQNMVMQIISEFIFLERTPKDGDVRKSQALPISQMNLFQEFQLIIALIEYFSRPGRDATRNAIFLSLFGSHLTPQRSKLLSRLISTAVSGSVAPLLSSAGTWMQQVGCKTPLSLEVAQNIVSDFISYSRKTPEQLKQLPMVGPHFAANFMVAVADLYLNEQRSPTLNPPPDALLDTITEWMMENPTLCQASQQPLVLPAGAIAMPFTTPLAGLLRWVVLAPLVSNRSAYSNLHLSLLRALQQLVSSGESTALPSQDLMQIVKSLQSYCARLAESKTDPQADAAYQKCMERFAQAVQIALSSNCITNQIQLLCLLESLPPHKLMKIVIEAHKK" }, { "InterPro": [ { "InterPro-ID": "IPR036574", "InterPro-Name": "Scorpion_toxin-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1, "End": 66 }, { "InterPro-ID": "IPR044062", "InterPro-Name": "LCN-type_CS_alpha_beta_dom", "InterPro-Type": "DOMAIN", "Beg": 1, "End": 66 }, { "InterPro-ID": "IPR003614", "InterPro-Name": "Scorpion_toxin-like", "InterPro-Type": "DOMAIN", "Beg": 1, "End": 51 }, { "InterPro-ID": "IPR002061", "InterPro-Name": "Scorpion_toxinL/defensin", "InterPro-Type": "FAMILY", "Beg": 1, "End": 53 }, { "InterPro-ID": "IPR018218", "InterPro-Name": "Scorpion_toxinL", "InterPro-Type": "FAMILY", "Beg": 35, "End": 45 }, { "InterPro-ID": "IPR018218", "InterPro-Name": "Scorpion_toxinL", "InterPro-Type": "FAMILY", "Beg": 11, "End": 18 }, { "InterPro-ID": "IPR018218", "InterPro-Name": "Scorpion_toxinL", "InterPro-Type": "FAMILY", "Beg": 45, "End": 58 }, { "InterPro-ID": "IPR018218", "InterPro-Name": "Scorpion_toxinL", "InterPro-Type": "FAMILY", "Beg": 22, "End": 29 } ], "response#1": "KEGYLVNHSTGCKYECFKLGDNDYCLRECRQQYGKGAGGYCYAFGCWCTHLYEQAVVWPLPKKTCN", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more LCN-type_CS_alpha_beta_dom, Scorpion_toxin-like that are essential for its biological function; 2. The protein should belong to Scorpion_toxinL/defensin, Scorpion_toxinL, Scorpion_toxinL, Scorpion_toxinL, Scorpion_toxinL that shares evolutionary origin and functional similarity; 3. The protein should be classified within Scorpion_toxin-like_sf sharing conserved structural features. The designed protein sequence is ", "reference": "KEGYLVNHSTGCKYECFKLGDNDYCLRECRQQYGKGAGGYCYAFGCWCTHLYEQAVVWPLPKKTCN" }, { "InterPro": [ { "InterPro-ID": "IPR048996", "InterPro-Name": "PGRS_rpt", "InterPro-Type": "REPEAT", "Beg": 125, "End": 192 }, { "InterPro-ID": "IPR000084", "InterPro-Name": "PE-PGRS_N", "InterPro-Type": "DOMAIN", "Beg": 4, "End": 94 } ], "response#1": "MSLLITSPATVAAAATHLAGIGSALSTANAAAAAPTTALSVAGADEVSVLIAALFEAYAQEYQALSAQALAFHDQFVQALNMGAVCYAAAETANATPLQALQTVQQNVLTVVNAPTQALLGRPIIGNGANGLPNTGQDGGPGGLLFGNGGNGGSGGVDQAGGNGGAAGLIGNGGSGGVGGPGIAGSAGGAGGAGGLLFGNGGPGGAGGIGTTGDGGPGGAGGNAIGLFGSGGTGGMGGVGGMGGVGNGGNAGNGGTAGLFGHGGAGGAGGIGSADGGLGGGGGNGRFMGNGGVGGAGGYGASGDGGNAGNGGLGGVFGDGGAGGTGGLGDVNGGLAGIGGNAGFVRNGGAGGNGQLGSGAVSSAGGMGGNGGLVFGNGGPGGLGGPGTSAGNGGMGGNAVGLFGQGGAGGAGGSGFGAGIPGGRGGDGGSGGLIGDGGTGGGAGAGDAAASAGGNGGNARLIGNGGDGGPGMFGGPGGAGGSGGTIFGFAGTPGPS", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more PE-PGRS_N that are essential for its biological function; 2. The protein should include one or more PGRS_rpt that provide structural or functional support. The designed protein sequence is ", "reference": "MSLLITSPATVAAAATHLAGIGSALSTANAAAAAPTTALSVAGADEVSVLIAALFEAYAQEYQALSAQALAFHDQFVQALNMGAVCYAAAETANATPLQALQTVQQNVLTVVNAPTQALLGRPIIGNGANGLPNTGQDGGPGGLLFGNGGNGGSGGVDQAGGNGGAAGLIGNGGSGGVGGPGIAGSAGGAGGAGGLLFGNGGPGGAGGIGTTGDGGPGGAGGNAIGLFGSGGTGGMGGVGGMGGVGNGGNAGNGGTAGLFGHGGAGGAGGIGSADGGLGGGGGNGRFMGNGGVGGAGGYGASGDGGNAGNGGLGGVFGDGGAGGTGGLGDVNGGLAGIGGNAGFVRNGGAGGNGQLGSGAVSSAGGMGGNGGLVFGNGGPGGLGGPGTSAGNGGMGGNAVGLFGQGGAGGAGGSGFGAGIPGGRGGDGGSGGLIGDGGTGGGAGAGDAAASAGGNGGNARLIGNGGDGGPGMFGGPGGAGGSGGTIFGFAGTPGPS" }, { "InterPro": [ { "InterPro-ID": "IPR004897", "InterPro-Name": "P/V_Pprotein_paramyxoviral", "InterPro-Type": "FAMILY", "Beg": 235, "End": 387 } ], "response#1": "MDQFIKQDETGDLIETGMNVANHFLSAPIQGTNSLSKASIIPGVAPVLIGNPEQKNIQHPTASHQGSKSKGRGSGVRSITVPPPEAGNGGTQIPEPLFAQTGQGGIVTTVHQDPTIQPTGSYRSVELAKIGKERMINRFVEKPRTSTPVTEFKRGGPGAAAQGQTIQEEGIDGNGASAGSKERSGSLSGATLYAHLSLPQQDSTPANVGIAPQSATSANEIMDLLRGMDARLQHLEQKVDKVLAQGSMVTQIKNELSTVKTTLATIEGMMATVKIMDPGNPTGVPVDELRRSFSDHVTIVSGPGDVSFSSSEEPTLYLDELARPVSKPRPAKQTKPQPVKDLAGRKVMITKMITDCVANPQMKQAFEQRLAKASTEDALNDIKRDIIRNAI", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to P/V_Pprotein_paramyxoviral that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MDQFIKQDETGDLIETGMNVANHFLSAPIQGTNSLSKASIIPGVAPVLIGNPEQKNIQHPTASHQGSKSKGRGSGVRSITVPPPEAGNGGTQIPEPLFAQTGQGGIVTTVHQDPTIQPTGSYRSVELAKIGKERMINRFVEKPRTSTPVTEFKRGGPGAAAQGQTIQEEGIDGNGASAGSKERSGSLSGATLYAHLSLPQQDSTPANVGIAPQSATSANEIMDLLRGMDARLQHLEQKVDKVLAQGSMVTQIKNELSTVKTTLATIEGMMATVKIMDPGNPTGVPVDELRRSFSDHVTIVSGPGDVSFSSSEEPTLYLDELARPVSKPRPAKQTKPQPVKDLAGRKVMITKMITDCVANPQMKQAFEQRLAKASTEDALNDIKRDIIRNAI" }, { "InterPro": [ { "InterPro-ID": "IPR036236", "InterPro-Name": "Znf_C2H2_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 308, "End": 356 }, { "InterPro-ID": "IPR036236", "InterPro-Name": "Znf_C2H2_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 220, "End": 265 }, { "InterPro-ID": "IPR013087", "InterPro-Name": "Znf_C2H2_type", "InterPro-Type": "DOMAIN", "Beg": 273, "End": 293 }, { "InterPro-ID": "IPR013087", "InterPro-Name": "Znf_C2H2_type", "InterPro-Type": "DOMAIN", "Beg": 439, "End": 466 }, { "InterPro-ID": "IPR013087", "InterPro-Name": "Znf_C2H2_type", "InterPro-Type": "DOMAIN", "Beg": 243, "End": 270 }, { "InterPro-ID": "IPR036236", "InterPro-Name": "Znf_C2H2_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 342, "End": 397 }, { "InterPro-ID": "IPR013087", "InterPro-Name": "Znf_C2H2_type", "InterPro-Type": "DOMAIN", "Beg": 334, "End": 356 }, { "InterPro-ID": "IPR013087", "InterPro-Name": "Znf_C2H2_type", "InterPro-Type": "DOMAIN", "Beg": 271, "End": 298 }, { "InterPro-ID": "IPR013087", "InterPro-Name": "Znf_C2H2_type", "InterPro-Type": "DOMAIN", "Beg": 245, "End": 265 }, { "InterPro-ID": "IPR013087", "InterPro-Name": "Znf_C2H2_type", "InterPro-Type": "DOMAIN", "Beg": 411, "End": 433 }, { "InterPro-ID": "IPR013087", "InterPro-Name": "Znf_C2H2_type", "InterPro-Type": "DOMAIN", "Beg": 439, "End": 461 }, { "InterPro-ID": "IPR013087", "InterPro-Name": "Znf_C2H2_type", "InterPro-Type": "DOMAIN", "Beg": 243, "End": 265 }, { "InterPro-ID": "IPR013087", "InterPro-Name": "Znf_C2H2_type", "InterPro-Type": "DOMAIN", "Beg": 299, "End": 328 }, { "InterPro-ID": "IPR013087", "InterPro-Name": "Znf_C2H2_type", "InterPro-Type": "DOMAIN", "Beg": 361, "End": 383 }, { "InterPro-ID": "IPR013087", "InterPro-Name": "Znf_C2H2_type", "InterPro-Type": "DOMAIN", "Beg": 495, "End": 517 }, { "InterPro-ID": "IPR013087", "InterPro-Name": "Znf_C2H2_type", "InterPro-Type": "DOMAIN", "Beg": 271, "End": 293 }, { "InterPro-ID": "IPR013087", "InterPro-Name": "Znf_C2H2_type", "InterPro-Type": "DOMAIN", "Beg": 411, "End": 438 }, { "InterPro-ID": "IPR013087", "InterPro-Name": "Znf_C2H2_type", "InterPro-Type": "DOMAIN", "Beg": 495, "End": 522 }, { "InterPro-ID": "IPR013087", "InterPro-Name": "Znf_C2H2_type", "InterPro-Type": "DOMAIN", "Beg": 441, "End": 461 }, { "InterPro-ID": "IPR013087", "InterPro-Name": "Znf_C2H2_type", "InterPro-Type": "DOMAIN", "Beg": 336, "End": 356 }, { "InterPro-ID": "IPR013087", "InterPro-Name": "Znf_C2H2_type", "InterPro-Type": "DOMAIN", "Beg": 361, "End": 384 }, { "InterPro-ID": "IPR036236", "InterPro-Name": "Znf_C2H2_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 251, "End": 306 }, { "InterPro-ID": "IPR013087", "InterPro-Name": "Znf_C2H2_type", "InterPro-Type": "DOMAIN", "Beg": 361, "End": 388 }, { "InterPro-ID": "IPR036236", "InterPro-Name": "Znf_C2H2_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 407, "End": 457 }, { "InterPro-ID": "IPR013087", "InterPro-Name": "Znf_C2H2_type", "InterPro-Type": "DOMAIN", "Beg": 413, "End": 433 }, { "InterPro-ID": "IPR036236", "InterPro-Name": "Znf_C2H2_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 475, "End": 532 } ], "response#1": "MEEVTSQEAAESPRGHFQPLENQSECLSPELRFLQDTDMEQGFSGGFPISKPDGISEREQDLQVFDLESKNREVIRGDCSDGETREENKLLIPKRKISEEVHSYKVRVGKFKQDIAQVPETREVYKSEDRLERLQEILRKFLFLEREFRQITISKKTFSSEKNTEPEKSFSLDSTLDTDQRVLRIQTTDDSKYDMNFNQNPAVGEQEPINLTENFQSTDYKESLMDLSHLNKWESMPTTDRSYKCDTCGKTFHQASALTRHQRIHTREKPYKCKECEKSFSQSSSLSRHKRIHTREKSYKCEASDKSCDAPDKSCSQSSDVLQHKKGHAKAKSYKCGTCERVFSRSVHLTQHQRTHKDMSCKCTVCGSDFCHTSYLVEHQRLHHQEKSYEYDECGLAYVKQQGIRFQEKPYSCNECGKDFRLNSHLIQHQRIHTGEKLHECNECGKSFSQTSCLIQHHKMHRKEKSYEYNNYEESFSHSSDLTLQQEVPIRERVFDCDAWEENFSQRAHLIQHERVHTKEKPYECSELGETFSQVQASFNM", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Znf_C2H2_type, Znf_C2H2_type, Znf_C2H2_type, Znf_C2H2_type, Znf_C2H2_type, Znf_C2H2_type, Znf_C2H2_type, Znf_C2H2_type, Znf_C2H2_type, Znf_C2H2_type, Znf_C2H2_type, Znf_C2H2_type, Znf_C2H2_type, Znf_C2H2_type, Znf_C2H2_type, Znf_C2H2_type, Znf_C2H2_type, Znf_C2H2_type, Znf_C2H2_type, Znf_C2H2_type that are essential for its biological function; 2. The protein should be classified within Znf_C2H2_sf, Znf_C2H2_sf, Znf_C2H2_sf, Znf_C2H2_sf, Znf_C2H2_sf, Znf_C2H2_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MEEVTSQEAAESPRGHFQPLENQSECLSPELRFLQDTDMEQGFSGGFPISKPDGISEREQDLQVFDLESKNREVIRGDCSDGETREENKLLIPKRKISEEVHSYKVRVGKFKQDIAQVPETREVYKSEDRLERLQEILRKFLFLEREFRQITISKKTFSSEKNTEPEKSFSLDSTLDTDQRVLRIQTTDDSKYDMNFNQNPAVGEQEPINLTENFQSTDYKESLMDLSHLNKWESMPTTDRSYKCDTCGKTFHQASALTRHQRIHTREKPYKCKECEKSFSQSSSLSRHKRIHTREKSYKCEASDKSCDAPDKSCSQSSDVLQHKKGHAKAKSYKCGTCERVFSRSVHLTQHQRTHKDMSCKCTVCGSDFCHTSYLVEHQRLHHQEKSYEYDECGLAYVKQQGIRFQEKPYSCNECGKDFRLNSHLIQHQRIHTGEKLHECNECGKSFSQTSCLIQHHKMHRKEKSYEYNNYEESFSHSSDLTLQQEVPIRERVFDCDAWEENFSQRAHLIQHERVHTKEKPYECSELGETFSQVQASFNM" }, { "InterPro": [ { "InterPro-ID": "IPR033469", "InterPro-Name": "CYTH-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 20, "End": 169 }, { "InterPro-ID": "IPR037009", "InterPro-Name": "mRNA_triPase_Cet1_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 87, "End": 192 } ], "response#1": "MATPKSFRDNLAEILKTHDFRTVELEFRLGFQAPGEFITNINKHVWTTAKEKLGTPAQELVMVDKYIRSTPGESSRYVVFPDGQGYWEHKKKVAKETTTGGKYGVRSAFSLERRENGKPPVSFRMQRTKYRTTFVKGPWKIDFTRVESIPATDRDCESTYEIEVELYDMFYLFEKELDIIIQEGNKLVQSIVM", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should be classified within CYTH-like_dom_sf, mRNA_triPase_Cet1_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MATPKSFRDNLAEILKTHDFRTVELEFRLGFQAPGEFITNINKHVWTTAKEKLGTPAQELVMVDKYIRSTPGESSRYVVFPDGQGYWEHKKKVAKETTTGGKYGVRSAFSLERRENGKPPVSFRMQRTKYRTTFVKGPWKIDFTRVESIPATDRDCESTYEIEVELYDMFYLFEKELDIIIQEGNKLVQSIVM" }, { "InterPro": [ { "InterPro-ID": "IPR050268", "InterPro-Name": "NADH-dep_flavin_reductase", "InterPro-Type": "FAMILY", "Beg": 8, "End": 161 }, { "InterPro-ID": "IPR012349", "InterPro-Name": "Split_barrel_FMN-bd", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1, "End": 161 }, { "InterPro-ID": "IPR002563", "InterPro-Name": "Flavin_Rdtase-like_dom", "InterPro-Type": "DOMAIN", "Beg": 15, "End": 158 }, { "InterPro-ID": "IPR002563", "InterPro-Name": "Flavin_Rdtase-like_dom", "InterPro-Type": "DOMAIN", "Beg": 16, "End": 157 } ], "response#1": "MKADVFDPRALREAFGAFPTAVTVITASDPAGRPVGFTANSFTSVSLDPPLLLVCVAKTARDYSTMTAAEHFAINILSEAQKDVSIKFARPLEDRFAAVDWARAPNGCPIFAQVAAWFECSMHDVIEAGDHVMMVGRVTAFKSSGLNGLGYARGGYFAPSVAAKANSSAAGGEIGAVAVLERHAALFPLGDQNLSLPRYSAAGGDPAKTLASQLERSGLSVHDWLSLLDL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Flavin_Rdtase-like_dom, Flavin_Rdtase-like_dom that are essential for its biological function; 2. The protein should belong to NADH-dep_flavin_reductase that shares evolutionary origin and functional similarity; 3. The protein should be classified within Split_barrel_FMN-bd sharing conserved structural features. The designed protein sequence is ", "reference": "MKADVFDPRALREAFGAFPTAVTVITASDPAGRPVGFTANSFTSVSLDPPLLLVCVAKTARDYSTMTAAEHFAINILSEAQKDVSIKFARPLEDRFAAVDWARAPNGCPIFAQVAAWFECSMHDVIEAGDHVMMVGRVTAFKSSGLNGLGYARGGYFAPSVAAKANSSAAGGEIGAVAVLERHAALFPLGDQNLSLPRYSAAGGDPAKTLASQLERSGLSVHDWLSLLDL" }, { "InterPro": [ { "InterPro-ID": "IPR000276", "InterPro-Name": "GPCR_Rhodpsn", "InterPro-Type": "FAMILY", "Beg": 223, "End": 247 }, { "InterPro-ID": "IPR000276", "InterPro-Name": "GPCR_Rhodpsn", "InterPro-Type": "FAMILY", "Beg": 262, "End": 288 }, { "InterPro-ID": "IPR000276", "InterPro-Name": "GPCR_Rhodpsn", "InterPro-Type": "FAMILY", "Beg": 49, "End": 70 }, { "InterPro-ID": "IPR000276", "InterPro-Name": "GPCR_Rhodpsn", "InterPro-Type": "FAMILY", "Beg": 132, "End": 153 }, { "InterPro-ID": "IPR000276", "InterPro-Name": "GPCR_Rhodpsn", "InterPro-Type": "FAMILY", "Beg": 97, "End": 119 }, { "InterPro-ID": "IPR000276", "InterPro-Name": "GPCR_Rhodpsn", "InterPro-Type": "FAMILY", "Beg": 34, "End": 275 }, { "InterPro-ID": "IPR017452", "InterPro-Name": "GPCR_Rhodpsn_7TM", "InterPro-Type": "DOMAIN", "Beg": 31, "End": 280 } ], "response#1": "MWPPVDVRSLTAESLGRASLILAVDLLLFVTSILNITVIAFTPDLSDVIGCYLISLSVADLLTAIFVIPLSIYSTLEGNWRIGGDNSIICKSAAYLQIALFCSTVYTFAWICIDRYSAMMKPSRYSEQSLTRCKCWIVFSWLTSMLLCCPIIVARMQVVFYPDAQLCVLDWSATSAYSVTLLLLVFVPTLVTVFNTGWKIWSAMRNPAALDDSQRMLVETDPNFVLTGFLFVTFFLSWLPLITLKVCELIWGPFDMDLSMLTFFFVWLAVSGPCCKFLIYMFTNHQFRRSFLSYISCSMCCSSRSRYEYHDIGNNSFL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more GPCR_Rhodpsn_7TM that are essential for its biological function; 2. The protein should belong to GPCR_Rhodpsn, GPCR_Rhodpsn, GPCR_Rhodpsn, GPCR_Rhodpsn, GPCR_Rhodpsn, GPCR_Rhodpsn that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MWPPVDVRSLTAESLGRASLILAVDLLLFVTSILNITVIAFTPDLSDVIGCYLISLSVADLLTAIFVIPLSIYSTLEGNWRIGGDNSIICKSAAYLQIALFCSTVYTFAWICIDRYSAMMKPSRYSEQSLTRCKCWIVFSWLTSMLLCCPIIVARMQVVFYPDAQLCVLDWSATSAYSVTLLLLVFVPTLVTVFNTGWKIWSAMRNPAALDDSQRMLVETDPNFVLTGFLFVTFFLSWLPLITLKVCELIWGPFDMDLSMLTFFFVWLAVSGPCCKFLIYMFTNHQFRRSFLSYISCSMCCSSRSRYEYHDIGNNSFL" }, { "InterPro": [ { "InterPro-ID": "IPR000045", "InterPro-Name": "Prepilin_IV_endopep_pep", "InterPro-Type": "DOMAIN", "Beg": 14, "End": 115 }, { "InterPro-ID": "IPR009639", "InterPro-Name": "Pept_A24A_C_arc", "InterPro-Type": "DOMAIN", "Beg": 210, "End": 316 } ], "response#1": "MFGFDNLILGVYLFNFLLILTATYTDIKERIIPHFVIILMLIVNLPIGYYFFGFDAITSFFATLILCLILGVGMGGGDVKMFTALSPLFAAETIYFVPKDISILIGLSALFAAIFPMTKILKNYWKDIIPSSAYLAMLIGIIVSITEIYSIGNTKTILWSYIILSIFISRKIPKYRIISNKLGYITPIYLIGFYLLNPAYFVSENVLISFFVYIGQLSLISLVIYALTGAEISSKKQISDLKEGDIIRDIVTIKENGEVTVENANILKRFKHMIYGEMGKLEGKSLMTDGEGLSDENLELLNKLQNEGKIGGELNVLTTYPFVPFVLVAYCVITLLNMGVINYLVG", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Prepilin_IV_endopep_pep, Pept_A24A_C_arc that are essential for its biological function. The designed protein sequence is ", "reference": "MFGFDNLILGVYLFNFLLILTATYTDIKERIIPHFVIILMLIVNLPIGYYFFGFDAITSFFATLILCLILGVGMGGGDVKMFTALSPLFAAETIYFVPKDISILIGLSALFAAIFPMTKILKNYWKDIIPSSAYLAMLIGIIVSITEIYSIGNTKTILWSYIILSIFISRKIPKYRIISNKLGYITPIYLIGFYLLNPAYFVSENVLISFFVYIGQLSLISLVIYALTGAEISSKKQISDLKEGDIIRDIVTIKENGEVTVENANILKRFKHMIYGEMGKLEGKSLMTDGEGLSDENLELLNKLQNEGKIGGELNVLTTYPFVPFVLVAYCVITLLNMGVINYLVG" }, { "InterPro": [ { "InterPro-ID": "IPR007166", "InterPro-Name": "Class3_signal_pept_motif", "InterPro-Type": "CONSERVED_SITE", "Beg": 5, "End": 30 } ], "response#1": "MAKFSKGQISIELILLMTAVLLAGILVSVNMTRFTFEGDILSDVREDAFQVFEISTDTPIIVYSLNFSNVKISPSTNLYNAWLQINDTGNDTYLWYYSDGTFKGLANTSDPDESITEENLVLLPHEGYASDIIFRSNVPTAMSWDSYEIDFNDIKKFEIIANDVENNPISYSLTHGDSPETSNQAYLNIKANEVTIIVTKANDKVFEVIANTTSGTIELLPYTETSP", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain Class3_signal_pept_motif that is preserved across related proteins. The designed protein sequence is ", "reference": "MAKFSKGQISIELILLMTAVLLAGILVSVNMTRFTFEGDILSDVREDAFQVFEISTDTPIIVYSLNFSNVKISPSTNLYNAWLQINDTGNDTYLWYYSDGTFKGLANTSDPDESITEENLVLLPHEGYASDIIFRSNVPTAMSWDSYEIDFNDIKKFEIIANDVENNPISYSLTHGDSPETSNQAYLNIKANEVTIIVTKANDKVFEVIANTTSGTIELLPYTETSP" }, { "InterPro": [ { "InterPro-ID": "IPR007166", "InterPro-Name": "Class3_signal_pept_motif", "InterPro-Type": "CONSERVED_SITE", "Beg": 6, "End": 32 } ], "response#1": "MLLNSKRGQVSIEMLILILAVLLSGTIFAAHMTKNTVSHDEISDVKKQTFKSFLGSVEGSTASSLPEKISEEDTSPEEDTIPEEDTSPEEDTIPEEDTIPEEDTSTEIPIGKNVKIYNLPIKEEKQNWFLDILNTALDRISAILDGFFSLFGLDLFNNDEIIPNILVKDFEGNRIPLSFDWERLSYTTDWFYAKEIEFTGDSSAKYSKLDLFRIFPIYSYSDTTFRITDLSYNLTYDVPPSTAKKTITITSNIPEGIKCKVTYKIGGILTGDYYTLEIDEKTSSNKYNNVNIAFE", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain Class3_signal_pept_motif that is preserved across related proteins. The designed protein sequence is ", "reference": "MLLNSKRGQVSIEMLILILAVLLSGTIFAAHMTKNTVSHDEISDVKKQTFKSFLGSVEGSTASSLPEKISEEDTSPEEDTIPEEDTSPEEDTIPEEDTIPEEDTSTEIPIGKNVKIYNLPIKEEKQNWFLDILNTALDRISAILDGFFSLFGLDLFNNDEIIPNILVKDFEGNRIPLSFDWERLSYTTDWFYAKEIEFTGDSSAKYSKLDLFRIFPIYSYSDTTFRITDLSYNLTYDVPPSTAKKTITITSNIPEGIKCKVTYKIGGILTGDYYTLEIDEKTSSNKYNNVNIAFE" }, { "InterPro": [ { "InterPro-ID": "IPR007166", "InterPro-Name": "Class3_signal_pept_motif", "InterPro-Type": "CONSERVED_SITE", "Beg": 3, "End": 25 } ], "response#1": "MSNRGQLSIEMVILVLAVLVSGSYVALDLSKGAFETTAVNDVQESSYCGFTPDFGATSIDKALVKLTTGIININPNAAVTNNEFNATYTNTTDNTVVTYSLDNVHPNLIKNYADGTIVKVPLNETWKNFTASNIILRMKSDYVCTINGENVSMESNCFEITAPLGSDSFDFQMSAGTGAGQYYLRLVDQEVTIEFSLE", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain Class3_signal_pept_motif that is preserved across related proteins. The designed protein sequence is ", "reference": "MSNRGQLSIEMVILVLAVLVSGSYVALDLSKGAFETTAVNDVQESSYCGFTPDFGATSIDKALVKLTTGIININPNAAVTNNEFNATYTNTTDNTVVTYSLDNVHPNLIKNYADGTIVKVPLNETWKNFTASNIILRMKSDYVCTINGENVSMESNCFEITAPLGSDSFDFQMSAGTGAGQYYLRLVDQEVTIEFSLE" }, { "InterPro": [ { "InterPro-ID": "IPR002259", "InterPro-Name": "Eqnu_transpt", "InterPro-Type": "FAMILY", "Beg": 177, "End": 197 }, { "InterPro-ID": "IPR002259", "InterPro-Name": "Eqnu_transpt", "InterPro-Type": "FAMILY", "Beg": 422, "End": 438 }, { "InterPro-ID": "IPR002259", "InterPro-Name": "Eqnu_transpt", "InterPro-Type": "FAMILY", "Beg": 149, "End": 171 }, { "InterPro-ID": "IPR002259", "InterPro-Name": "Eqnu_transpt", "InterPro-Type": "FAMILY", "Beg": 24, "End": 486 }, { "InterPro-ID": "IPR002259", "InterPro-Name": "Eqnu_transpt", "InterPro-Type": "FAMILY", "Beg": 150, "End": 483 }, { "InterPro-ID": "IPR034764", "InterPro-Name": "ENT1/ENT2", "InterPro-Type": "FAMILY", "Beg": 33, "End": 488 } ], "response#1": "MDTAPDHREPQEQGESRKWYEMTASEFYVYVVAFMCGVSMMMSVNAVFSAPAYIMTYYRYAMQDPEAVPLYTNFWNNVMTYYNLIGIVTSLIMEPLTLLSWFRRIPIKVRLLGGLVILIVEIIVLMVVPARGTSEAGAVATICCTGFIGGFGKSIFESTAYGMFGAFPSSFTSTMMGGVGMSGVLTSLLQIIVKAALPDSYEGVKKQSKIYYGLDVGIQGMTFVALILLRFNSFAQNYFGDLGAVKSKVDAGKLSAEALCHTDEHPTHDKEGRNSSSGKEVPALGEVQTAAAKSEGPDAVEESSWPHEVEGPTSNEILVATAIFSTLRRVKWMFVACAFNFLITLFLFPGIAVGMFPDSKWFSTIAVFIFNVFDVLGRFSPSLKLMWPRSYKQRWIIVAASFARVIFVPLLLLHSYHYIPGEAYGYVMEVIFGFSNGYVGSMALVLGPQSKGIDNDGKRFVAGTLMGISILVGGTIGTVLSIMTQTIRERH", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Eqnu_transpt, Eqnu_transpt, Eqnu_transpt, Eqnu_transpt, Eqnu_transpt, ENT1/ENT2 that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MDTAPDHREPQEQGESRKWYEMTASEFYVYVVAFMCGVSMMMSVNAVFSAPAYIMTYYRYAMQDPEAVPLYTNFWNNVMTYYNLIGIVTSLIMEPLTLLSWFRRIPIKVRLLGGLVILIVEIIVLMVVPARGTSEAGAVATICCTGFIGGFGKSIFESTAYGMFGAFPSSFTSTMMGGVGMSGVLTSLLQIIVKAALPDSYEGVKKQSKIYYGLDVGIQGMTFVALILLRFNSFAQNYFGDLGAVKSKVDAGKLSAEALCHTDEHPTHDKEGRNSSSGKEVPALGEVQTAAAKSEGPDAVEESSWPHEVEGPTSNEILVATAIFSTLRRVKWMFVACAFNFLITLFLFPGIAVGMFPDSKWFSTIAVFIFNVFDVLGRFSPSLKLMWPRSYKQRWIIVAASFARVIFVPLLLLHSYHYIPGEAYGYVMEVIFGFSNGYVGSMALVLGPQSKGIDNDGKRFVAGTLMGISILVGGTIGTVLSIMTQTIRERH" }, { "InterPro": [ { "InterPro-ID": "IPR048963", "InterPro-Name": "ArgZ/ArgE-like_C_2nd", "InterPro-Type": "DOMAIN", "Beg": 187, "End": 404 }, { "InterPro-ID": "IPR005239", "InterPro-Name": "ArgZ/ArgE-like", "InterPro-Type": "FAMILY", "Beg": 1, "End": 411 }, { "InterPro-ID": "IPR007545", "InterPro-Name": "LOR/SDH_bifunc_enz_cons_dom", "InterPro-Type": "DOMAIN", "Beg": 4, "End": 117 }, { "InterPro-ID": "IPR048964", "InterPro-Name": "ArgZ/ArgE-like_C_1st", "InterPro-Type": "DOMAIN", "Beg": 103, "End": 186 }, { "InterPro-ID": "IPR007545", "InterPro-Name": "LOR/SDH_bifunc_enz_cons_dom", "InterPro-Type": "DOMAIN", "Beg": 4, "End": 102 } ], "response#1": "MFMREIELKGHIIDSFILAKVFDRTLELGGDYKVLEFDIGKKKIDTSYAKLLISGDTQQHLDQILEELQNVGANIPEIENANLKPALKDSVLPDGFYSTTNHPTHVKVNDEWIEVANPKMDAVIVVYPEEKRAETKVIRKVKKGDFVLIGHNGIRVMPPEKSREAGQLFEFMNSEVSSEKPKEAIIKRIAKEMHEIREEYKKTGTGGIAIVGGPAIIHTGGGPALAKMVELGYIQAILAGNALATHDIESALYGTSLGVNIKTAKPVTGGHKHHIYAINAINDAGNIKNAVESGVLKEGIMYQCIKNNIPYVLAGSIRDDGPIPDVITDSMVAQDKMRTTVMDKKMVIMLSTLLHSVATGNLMPSYIKTVCVDIQPSTVTKLMDRGTSQAIGVVTDVGVFLVLLLKELERLELQE", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more ArgZ/ArgE-like_C_2nd, LOR/SDH_bifunc_enz_cons_dom, ArgZ/ArgE-like_C_1st, LOR/SDH_bifunc_enz_cons_dom that are essential for its biological function; 2. The protein should belong to ArgZ/ArgE-like that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MFMREIELKGHIIDSFILAKVFDRTLELGGDYKVLEFDIGKKKIDTSYAKLLISGDTQQHLDQILEELQNVGANIPEIENANLKPALKDSVLPDGFYSTTNHPTHVKVNDEWIEVANPKMDAVIVVYPEEKRAETKVIRKVKKGDFVLIGHNGIRVMPPEKSREAGQLFEFMNSEVSSEKPKEAIIKRIAKEMHEIREEYKKTGTGGIAIVGGPAIIHTGGGPALAKMVELGYIQAILAGNALATHDIESALYGTSLGVNIKTAKPVTGGHKHHIYAINAINDAGNIKNAVESGVLKEGIMYQCIKNNIPYVLAGSIRDDGPIPDVITDSMVAQDKMRTTVMDKKMVIMLSTLLHSVATGNLMPSYIKTVCVDIQPSTVTKLMDRGTSQAIGVVTDVGVFLVLLLKELERLELQE" }, { "InterPro": [ { "InterPro-ID": "IPR042539", "InterPro-Name": "Matrix_C", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 191, "End": 356 }, { "InterPro-ID": "IPR055413", "InterPro-Name": "Matrix_Paramyxo_C", "InterPro-Type": "DOMAIN", "Beg": 186, "End": 348 }, { "InterPro-ID": "IPR042540", "InterPro-Name": "Matrix_N", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 2, "End": 190 }, { "InterPro-ID": "IPR000982", "InterPro-Name": "Matrix_Paramyxo_N", "InterPro-Type": "DOMAIN", "Beg": 10, "End": 183 } ], "response#1": "MAGSQIKIPLPKPPDSDSQRLNAFPIIMAQEGKGRLLRQIRLRKILSGDPSDQQITFVNTYGFIRATPETSEFISESSPQKVTPVVTACMLSFGAGPVLEDPQHMLKALDQTDIRVRKTASDKEQILFEINRIPNLFRHHQISADHLIQASSDKYVKSPAKLIAGVNYIYCVTFLSVTVCSASLKFRVARPLLAARSRLVRAVQMEVLLRVTCKKDSQMAKSMLNDPEGEGCIASVWFHLCNLCKGRNKLRSYDENYFASKCRKMNLTVSIGDMWGPTILVHAGGHIPTTAKPFFNSRGWVCHPIHQSSPSLAKTLWSSGCEIKAASAILQGSDYASLAKTDDIIYSKIKVDKDAANYKGVSWSPFRKSASMSNL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Matrix_Paramyxo_C, Matrix_Paramyxo_N that are essential for its biological function; 2. The protein should be classified within Matrix_C, Matrix_N sharing conserved structural features. The designed protein sequence is ", "reference": "MAGSQIKIPLPKPPDSDSQRLNAFPIIMAQEGKGRLLRQIRLRKILSGDPSDQQITFVNTYGFIRATPETSEFISESSPQKVTPVVTACMLSFGAGPVLEDPQHMLKALDQTDIRVRKTASDKEQILFEINRIPNLFRHHQISADHLIQASSDKYVKSPAKLIAGVNYIYCVTFLSVTVCSASLKFRVARPLLAARSRLVRAVQMEVLLRVTCKKDSQMAKSMLNDPEGEGCIASVWFHLCNLCKGRNKLRSYDENYFASKCRKMNLTVSIGDMWGPTILVHAGGHIPTTAKPFFNSRGWVCHPIHQSSPSLAKTLWSSGCEIKAASAILQGSDYASLAKTDDIIYSKIKVDKDAANYKGVSWSPFRKSASMSNL" }, { "InterPro": [ { "InterPro-ID": "IPR002259", "InterPro-Name": "Eqnu_transpt", "InterPro-Type": "FAMILY", "Beg": 24, "End": 486 }, { "InterPro-ID": "IPR002259", "InterPro-Name": "Eqnu_transpt", "InterPro-Type": "FAMILY", "Beg": 177, "End": 197 }, { "InterPro-ID": "IPR002259", "InterPro-Name": "Eqnu_transpt", "InterPro-Type": "FAMILY", "Beg": 422, "End": 438 }, { "InterPro-ID": "IPR002259", "InterPro-Name": "Eqnu_transpt", "InterPro-Type": "FAMILY", "Beg": 149, "End": 171 }, { "InterPro-ID": "IPR034764", "InterPro-Name": "ENT1/ENT2", "InterPro-Type": "FAMILY", "Beg": 33, "End": 489 }, { "InterPro-ID": "IPR002259", "InterPro-Name": "Eqnu_transpt", "InterPro-Type": "FAMILY", "Beg": 150, "End": 483 } ], "response#1": "MDTAPDHREPQEQGESRKWYEMTASEFYVYVVAFMCGVSMMMPVNAVFSAPAYIMTYYRYAMQDPEAVPLYTNFWNNVMTYYNLIGIVTSLIMEPLTLLSWFRRIPMKVRLLGGLVILIVEIIVLMVVPARGTSEAGAVATICCTGFIGGFGKSIFESTTYGMFGAFPSSFTSTMMGGVGMSGVLTSLLQIIVKAALPDSYEGVKKQSKIYYGLDVGIQGMTFVALILLRFNSFAQNYFGDLGAVKSKVDAGKLSAEALCHTDEHPTHDKEGRNSSSGKEVPALGEVQTAAAKSEGPDAVEESSWPHEVEGPTSNEILVATAIFSTLRRVKWMFVACAFNFLITLFLFPGIAVGMFPDSKWFSTIAVFIFNVFDVLGRFSPSLKLMWPRSYKQRWIIVAASFARVIFVPLLLLHSYHYIPGEAYGYVMEVIFGFSNGYVGSMALVLGPQSKGIDNDGKRFVAGTLMGISILVGGTIGTVLSIMTQTIRATY", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Eqnu_transpt, Eqnu_transpt, Eqnu_transpt, Eqnu_transpt, ENT1/ENT2, Eqnu_transpt that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MDTAPDHREPQEQGESRKWYEMTASEFYVYVVAFMCGVSMMMPVNAVFSAPAYIMTYYRYAMQDPEAVPLYTNFWNNVMTYYNLIGIVTSLIMEPLTLLSWFRRIPMKVRLLGGLVILIVEIIVLMVVPARGTSEAGAVATICCTGFIGGFGKSIFESTTYGMFGAFPSSFTSTMMGGVGMSGVLTSLLQIIVKAALPDSYEGVKKQSKIYYGLDVGIQGMTFVALILLRFNSFAQNYFGDLGAVKSKVDAGKLSAEALCHTDEHPTHDKEGRNSSSGKEVPALGEVQTAAAKSEGPDAVEESSWPHEVEGPTSNEILVATAIFSTLRRVKWMFVACAFNFLITLFLFPGIAVGMFPDSKWFSTIAVFIFNVFDVLGRFSPSLKLMWPRSYKQRWIIVAASFARVIFVPLLLLHSYHYIPGEAYGYVMEVIFGFSNGYVGSMALVLGPQSKGIDNDGKRFVAGTLMGISILVGGTIGTVLSIMTQTIRATY" }, { "InterPro": [ { "InterPro-ID": "IPR043129", "InterPro-Name": "ATPase_NBD", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 172, "End": 356 } ], "response#1": "MSDDTEDDSGGESTADMEFGEQPAPLGVKVGSTRTVVAEDDADSPSVTQTLTCLATYDDALTGEEHVIYGAEAATEYPDRVRFMLRSGLPEDEETTGLAKRFFEEFASANGLDTDSVVVYAIPTIDNEAGLDRLAEIIEDGPVGERRIASYPESLCGAVPALGDGLDAIEDTFVAINMGSTNLEACAYRRGEQLAPFSTGAITGTEVDRRIANYVEEETQGRVNIDLTTAREYKEQHADFNDYEPFSDIIQQPGGGTYEFTIEDAVMDAVDEFVDAAVDEVANVFLPDLASDYVKIYQQALDNPIVLTGGMGCIPGIVSEFETRLGEEIDREVEATTADEPETAAARGAHRIAERLVDLGEY", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should be classified within ATPase_NBD sharing conserved structural features. The designed protein sequence is ", "reference": "MSDDTEDDSGGESTADMEFGEQPAPLGVKVGSTRTVVAEDDADSPSVTQTLTCLATYDDALTGEEHVIYGAEAATEYPDRVRFMLRSGLPEDEETTGLAKRFFEEFASANGLDTDSVVVYAIPTIDNEAGLDRLAEIIEDGPVGERRIASYPESLCGAVPALGDGLDAIEDTFVAINMGSTNLEACAYRRGEQLAPFSTGAITGTEVDRRIANYVEEETQGRVNIDLTTAREYKEQHADFNDYEPFSDIIQQPGGGTYEFTIEDAVMDAVDEFVDAAVDEVANVFLPDLASDYVKIYQQALDNPIVLTGGMGCIPGIVSEFETRLGEEIDREVEATTADEPETAAARGAHRIAERLVDLGEY" }, { "InterPro": [ { "InterPro-ID": "IPR005112", "InterPro-Name": "dDENN_dom", "InterPro-Type": "DOMAIN", "Beg": 978, "End": 1027 }, { "InterPro-ID": "IPR005113", "InterPro-Name": "uDENN_dom", "InterPro-Type": "DOMAIN", "Beg": 231, "End": 330 }, { "InterPro-ID": "IPR037516", "InterPro-Name": "Tripartite_DENN", "InterPro-Type": "DOMAIN", "Beg": 242, "End": 1019 }, { "InterPro-ID": "IPR046349", "InterPro-Name": "C1-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 876, "End": 935 }, { "InterPro-ID": "IPR001194", "InterPro-Name": "cDENN_dom", "InterPro-Type": "DOMAIN", "Beg": 435, "End": 632 }, { "InterPro-ID": "IPR005112", "InterPro-Name": "dDENN_dom", "InterPro-Type": "DOMAIN", "Beg": 939, "End": 1011 }, { "InterPro-ID": "IPR005113", "InterPro-Name": "uDENN_dom", "InterPro-Type": "DOMAIN", "Beg": 262, "End": 328 }, { "InterPro-ID": "IPR043153", "InterPro-Name": "DENN_C", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 528, "End": 667 }, { "InterPro-ID": "IPR002219", "InterPro-Name": "PE/DAG-bd", "InterPro-Type": "DOMAIN", "Beg": 886, "End": 934 }, { "InterPro-ID": "IPR051696", "InterPro-Name": "DENN_Domain_GEFs", "InterPro-Type": "FAMILY", "Beg": 941, "End": 1032 } ], "response#1": "MESSSTPLAEYFWIAGVESVSYQDPNSQPAPAVPVESTIIEDGEPEDEWTNGGQPKTNARHSRQNSASRLSKMSLTERFSIQTLDDTDGNTKSNRSSATIRAVNPPDFSNGNDDSNGNSQNPAPSGTLGEGSMFMGDFDFDKALVKFAAEREVFLEDLTFSAGAKVQARAPMVNPRMERIRAEESDSGRLSPLRSIKGSIRRKMSFRDMNSVRKQPSNRISTSRAASIRTTRRLSNYNSVIPPPEPLNTDPDMHPLKRRFEPVLLDRYPPQEAGDEISRRGRFPDYVPMFAFPNDIQIVSSDDRPRSTWHGFTMTSDDNSKLYGITIIIWIALNADVAEDVEKKCEEWRQSHMSEEERELAASLGVRLAGERTHLSQLLAKLPTIPSGSPARERLEDEISTVEEKITLMTDMLRPLRHGAASKIEGLTAGESGLWAPRAYGILGRDAGNMSFWKEWLKAIVTPMTDGSVLRIPPSSPRVGRWQPLERYVVNLCTEAFNPLGSKTQVELGVRELRLYARKEADNEIPGSRTIDIYALFRCLSLENIVALFEYAMAESRIIFLSSHASMLHLACHALANLLYPLKWASIFIPILPARLLSALEAPCPYIVGIERRYDNIELPEDDYVLVDLDKDTIDATSQPVRLPRQARRKLMSLLQVAAPHKLRYGVATGPPPYAMESFPYDAFSTENGSLFRTSTPKSTLGKWVSQSSSGFGEADPPNEIQPPIFNAFASAHVENGKSDRPSTSKSGKTSPQSSVSPVSINFPPMPSTPVSRSDSGFALASTLREKRSGHFGEEKMRRSSSFGVDKHPPFQKPGMPFLNGHQANLSISAISVESQNSVIGGANGGYGGGYAPSTYAQSTLAASTIMPSMQIQPVRNTETTVWVEGHCFNYMPKDNTSMCTICNDLAEGDGVYRCTGCKIVSHGRCLGYCSLICPEAFHADRVRAAFVRCLASLLYTYRKYLGRPSKQQKSNGQLYAFDMDGFIKSLPHDQHDYAAMMRETQCFNEFIHDREMQPANDASIRLFDEIIMAKKARGRSGLATGLSRLSTLRASHGASTYGGFGPARGGSNSKIPAFLGDISDHIWRTASVPLPKGNFPGEYKTIVTRTPARLDRSLMREPRSIQGMPRVEPRGTRGLIRKQVPNMFGTTPPT", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more dDENN_dom, uDENN_dom, Tripartite_DENN, cDENN_dom, dDENN_dom, uDENN_dom, PE/DAG-bd that are essential for its biological function; 2. The protein should belong to DENN_Domain_GEFs that shares evolutionary origin and functional similarity; 3. The protein should be classified within C1-like_sf, DENN_C sharing conserved structural features. The designed protein sequence is ", "reference": "MESSSTPLAEYFWIAGVESVSYQDPNSQPAPAVPVESTIIEDGEPEDEWTNGGQPKTNARHSRQNSASRLSKMSLTERFSIQTLDDTDGNTKSNRSSATIRAVNPPDFSNGNDDSNGNSQNPAPSGTLGEGSMFMGDFDFDKALVKFAAEREVFLEDLTFSAGAKVQARAPMVNPRMERIRAEESDSGRLSPLRSIKGSIRRKMSFRDMNSVRKQPSNRISTSRAASIRTTRRLSNYNSVIPPPEPLNTDPDMHPLKRRFEPVLLDRYPPQEAGDEISRRGRFPDYVPMFAFPNDIQIVSSDDRPRSTWHGFTMTSDDNSKLYGITIIIWIALNADVAEDVEKKCEEWRQSHMSEEERELAASLGVRLAGERTHLSQLLAKLPTIPSGSPARERLEDEISTVEEKITLMTDMLRPLRHGAASKIEGLTAGESGLWAPRAYGILGRDAGNMSFWKEWLKAIVTPMTDGSVLRIPPSSPRVGRWQPLERYVVNLCTEAFNPLGSKTQVELGVRELRLYARKEADNEIPGSRTIDIYALFRCLSLENIVALFEYAMAESRIIFLSSHASMLHLACHALANLLYPLKWASIFIPILPARLLSALEAPCPYIVGIERRYDNIELPEDDYVLVDLDKDTIDATSQPVRLPRQARRKLMSLLQVAAPHKLRYGVATGPPPYAMESFPYDAFSTENGSLFRTSTPKSTLGKWVSQSSSGFGEADPPNEIQPPIFNAFASAHVENGKSDRPSTSKSGKTSPQSSVSPVSINFPPMPSTPVSRSDSGFALASTLREKRSGHFGEEKMRRSSSFGVDKHPPFQKPGMPFLNGHQANLSISAISVESQNSVIGGANGGYGGGYAPSTYAQSTLAASTIMPSMQIQPVRNTETTVWVEGHCFNYMPKDNTSMCTICNDLAEGDGVYRCTGCKIVSHGRCLGYCSLICPEAFHADRVRAAFVRCLASLLYTYRKYLGRPSKQQKSNGQLYAFDMDGFIKSLPHDQHDYAAMMRETQCFNEFIHDREMQPANDASIRLFDEIIMAKKARGRSGLATGLSRLSTLRASHGASTYGGFGPARGGSNSKIPAFLGDISDHIWRTASVPLPKGNFPGEYKTIVTRTPARLDRSLMREPRSIQGMPRVEPRGTRGLIRKQVPNMFGTTPPT" }, { "InterPro": [ { "InterPro-ID": "IPR043129", "InterPro-Name": "ATPase_NBD", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 164, "End": 318 } ], "response#1": "MAKGLDVGTMNILSASQDGSETVFVQQRNSFVEIDYSDMAEQMLSRSDVLHIRKDDKVYVVGDDALNFANIFGKETRRPMQHGILSSEESSAIPMIKLIIEQVVGSPSRPNERLFYSSPADPIDSDLSTLYHDKTLESMLGDMGYDPEPINEGMAVIYSELADNNFTGLGVSFGAGMTNICLAYYAVPVMQFSIARGGDWIDQQTAQATGTAVDKVTSIKEDDFQLDFRTDVGGVEGALSIYYENLLDYVIENIEREVDEEDIEEGLDVPVVVTGGTSSPEGFEELFEHHLEDSTIPFSVNEVRSIDRPLYSVARGSLVAARSEEESDGGASDPEPEAEAAPESN", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should be classified within ATPase_NBD sharing conserved structural features. The designed protein sequence is ", "reference": "MAKGLDVGTMNILSASQDGSETVFVQQRNSFVEIDYSDMAEQMLSRSDVLHIRKDDKVYVVGDDALNFANIFGKETRRPMQHGILSSEESSAIPMIKLIIEQVVGSPSRPNERLFYSSPADPIDSDLSTLYHDKTLESMLGDMGYDPEPINEGMAVIYSELADNNFTGLGVSFGAGMTNICLAYYAVPVMQFSIARGGDWIDQQTAQATGTAVDKVTSIKEDDFQLDFRTDVGGVEGALSIYYENLLDYVIENIEREVDEEDIEEGLDVPVVVTGGTSSPEGFEELFEHHLEDSTIPFSVNEVRSIDRPLYSVARGSLVAARSEEESDGGASDPEPEAEAAPESN" }, { "InterPro": [ { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 241, "End": 515 }, { "InterPro-ID": "IPR003593", "InterPro-Name": "AAA+_ATPase", "InterPro-Type": "DOMAIN", "Beg": 277, "End": 415 }, { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 241, "End": 513 }, { "InterPro-ID": "IPR041569", "InterPro-Name": "AAA_lid_3", "InterPro-Type": "DOMAIN", "Beg": 438, "End": 471 }, { "InterPro-ID": "IPR050304", "InterPro-Name": "MT-severing_AAA_ATPase", "InterPro-Type": "FAMILY", "Beg": 91, "End": 517 }, { "InterPro-ID": "IPR003960", "InterPro-Name": "ATPase_AAA_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 385, "End": 404 }, { "InterPro-ID": "IPR015415", "InterPro-Name": "Spast_Vps4_C", "InterPro-Type": "DOMAIN", "Beg": 479, "End": 517 }, { "InterPro-ID": "IPR003959", "InterPro-Name": "ATPase_AAA_core", "InterPro-Type": "DOMAIN", "Beg": 281, "End": 413 } ], "response#1": "MLDKLSKHKTMFYERVKEIDQILFSQQQAKQTQLDNLSNNNASGGFFSGFMKMFSPLSTPPNSSSNNNSNTQQAISQETRKLCSVNNNRHEPIYNQYTTNSQVIRSFPAVSSIGQSSTNMYNSVNICDGISSSEKRSPTPPRNRSNSNDKILFGHYDALGSLPQNNMGHYQQPPQQSSQQQQQPLVPKQNSVTALRNTTSATSSTTTANNKKPSLDQIPELKGVDRKLLDHILNEVIETKTTNWDDIAGLKDAKQTLLETVILPSIRPDLFNGLRAPCRGILLFGPPGTGKTMIARACASQCNATFFSISAGSLVSKYHGEGEKLVRCLFAAARYLQPSVIFIDEIDSILSARSSEEHEASRRMKTEFMIQMDGVSNMNGKEDRVLVMGATNIPTELDEAILRRFTKRIYIPLPDHAARASLIKQLSHGQNMSLSETDINKICVATEGFSGSDLTALCKETSMVPLREISMDQLISIDARKIRPIVLKDFQSSLVHVRPSTSQDTIKKLEKWNESYGTFAKGI", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more AAA+_ATPase, AAA_lid_3, Spast_Vps4_C, ATPase_AAA_core that are essential for its biological function; 2. The protein should belong to MT-severing_AAA_ATPase that shares evolutionary origin and functional similarity; 3. The protein should be classified within P-loop_NTPase, P-loop_NTPase sharing conserved structural features; 4. The protein should contain ATPase_AAA_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MLDKLSKHKTMFYERVKEIDQILFSQQQAKQTQLDNLSNNNASGGFFSGFMKMFSPLSTPPNSSSNNNSNTQQAISQETRKLCSVNNNRHEPIYNQYTTNSQVIRSFPAVSSIGQSSTNMYNSVNICDGISSSEKRSPTPPRNRSNSNDKILFGHYDALGSLPQNNMGHYQQPPQQSSQQQQQPLVPKQNSVTALRNTTSATSSTTTANNKKPSLDQIPELKGVDRKLLDHILNEVIETKTTNWDDIAGLKDAKQTLLETVILPSIRPDLFNGLRAPCRGILLFGPPGTGKTMIARACASQCNATFFSISAGSLVSKYHGEGEKLVRCLFAAARYLQPSVIFIDEIDSILSARSSEEHEASRRMKTEFMIQMDGVSNMNGKEDRVLVMGATNIPTELDEAILRRFTKRIYIPLPDHAARASLIKQLSHGQNMSLSETDINKICVATEGFSGSDLTALCKETSMVPLREISMDQLISIDARKIRPIVLKDFQSSLVHVRPSTSQDTIKKLEKWNESYGTFAKGI" }, { "InterPro": [ { "InterPro-ID": "IPR026617", "InterPro-Name": "SMCO2/5", "InterPro-Type": "FAMILY", "Beg": 13, "End": 287 }, { "InterPro-ID": "IPR026617", "InterPro-Name": "SMCO2/5", "InterPro-Type": "FAMILY", "Beg": 1, "End": 288 } ], "response#1": "MEILRLAQSKKNIISLNMDLERDMQRIDEANQELLLKIQEKESEVQRLEHEITQTGDPAEDEEWEKENYTVMEREQALQELEEETARLERKNETLVHSISELQRKLTRKSQKIVRCEQGDLERTPEESKVKLQLLESSCADQEKELGKIMEDYVFVSQLCEDQALCIKKYQEALKRIEEELETGYLEREVSKVLSMDSEREKTVSLNEKDGFISNGALRFSKRIFRSLLFSTLFFIRLLGYLIFHLSFINPDLLVNALPKILSRDVLWKLRCFLFPSLTLETEDMLPH", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to SMCO2/5, SMCO2/5 that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MEILRLAQSKKNIISLNMDLERDMQRIDEANQELLLKIQEKESEVQRLEHEITQTGDPAEDEEWEKENYTVMEREQALQELEEETARLERKNETLVHSISELQRKLTRKSQKIVRCEQGDLERTPEESKVKLQLLESSCADQEKELGKIMEDYVFVSQLCEDQALCIKKYQEALKRIEEELETGYLEREVSKVLSMDSEREKTVSLNEKDGFISNGALRFSKRIFRSLLFSTLFFIRLLGYLIFHLSFINPDLLVNALPKILSRDVLWKLRCFLFPSLTLETEDMLPH" }, { "InterPro": [ { "InterPro-ID": "IPR004839", "InterPro-Name": "Aminotransferase_I/II_large", "InterPro-Type": "DOMAIN", "Beg": 45, "End": 394 }, { "InterPro-ID": "IPR015424", "InterPro-Name": "PyrdxlP-dep_Trfase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 21, "End": 401 }, { "InterPro-ID": "IPR050087", "InterPro-Name": "AON_synthase_class-II", "InterPro-Type": "FAMILY", "Beg": 44, "End": 396 }, { "InterPro-ID": "IPR001917", "InterPro-Name": "Aminotrans_II_pyridoxalP_BS", "InterPro-Type": "BINDING_SITE", "Beg": 247, "End": 256 }, { "InterPro-ID": "IPR015422", "InterPro-Name": "PyrdxlP-dep_Trfase_small", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 41, "End": 396 }, { "InterPro-ID": "IPR015421", "InterPro-Name": "PyrdxlP-dep_Trfase_major", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 60, "End": 300 } ], "response#1": "MKDLFEHIYANKGSIGRWSDHAEGYYVFPKLEGELGPHMKFQGKEILNWSINDYLGLANHPEVRKVDAEAAAEYGAAYPMGARMMSGHTTMHEELEKRLAKFVHKEASYLLNFGYQGMVSIIDALVTKNDVIVYDVDAHACIIDGVRLHFGKRYTYQHNDMESFEKNLERAAKLAETTGGGILVISEGVFGMRGEQGKLKEIVALKKKYPFRLLVDDAHGFGTLGPRGEGTGVHQGVQDEIDVYFSTFAKSMAGIGAFVAGNAKVVDYLKYNLRSQMFAKSLPMIYVKGALKRLEMMETMPELQQKLWDNVNRLQNGLKERGFNIGNTNTCVTPVFLHGSIPEAMAMVNDLREHYGIFLSIVVYPVIPKGMILLRIIPTASHSKEDIDRTLEAFSAIREKLETGVYRAINAELTKEMGDM", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Aminotransferase_I/II_large that are essential for its biological function; 2. The protein should belong to AON_synthase_class-II that shares evolutionary origin and functional similarity; 3. The protein should be classified within PyrdxlP-dep_Trfase, PyrdxlP-dep_Trfase_small, PyrdxlP-dep_Trfase_major sharing conserved structural features; 4. The protein should include a Aminotrans_II_pyridoxalP_BS that enables ligand binding under diverse conditions. The designed protein sequence is ", "reference": "MKDLFEHIYANKGSIGRWSDHAEGYYVFPKLEGELGPHMKFQGKEILNWSINDYLGLANHPEVRKVDAEAAAEYGAAYPMGARMMSGHTTMHEELEKRLAKFVHKEASYLLNFGYQGMVSIIDALVTKNDVIVYDVDAHACIIDGVRLHFGKRYTYQHNDMESFEKNLERAAKLAETTGGGILVISEGVFGMRGEQGKLKEIVALKKKYPFRLLVDDAHGFGTLGPRGEGTGVHQGVQDEIDVYFSTFAKSMAGIGAFVAGNAKVVDYLKYNLRSQMFAKSLPMIYVKGALKRLEMMETMPELQQKLWDNVNRLQNGLKERGFNIGNTNTCVTPVFLHGSIPEAMAMVNDLREHYGIFLSIVVYPVIPKGMILLRIIPTASHSKEDIDRTLEAFSAIREKLETGVYRAINAELTKEMGDM" }, { "InterPro": [ { "InterPro-ID": "IPR001926", "InterPro-Name": "TrpB-like_PALP", "InterPro-Type": "DOMAIN", "Beg": 14, "End": 309 }, { "InterPro-ID": "IPR036052", "InterPro-Name": "TrpB-like_PALP_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 9, "End": 331 }, { "InterPro-ID": "IPR036052", "InterPro-Name": "TrpB-like_PALP_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 47, "End": 160 }, { "InterPro-ID": "IPR036052", "InterPro-Name": "TrpB-like_PALP_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 17, "End": 317 }, { "InterPro-ID": "IPR050214", "InterPro-Name": "Cys_Synth/Cystath_Beta-Synth", "InterPro-Type": "FAMILY", "Beg": 11, "End": 328 } ], "response#1": "MKIDESLNVHSSLLQLIGNTPLLELHKITKGLKGRYFAKLEAFNVGHSAKDRVAKYIVEDAERKGLLKPGSTIVETSSGNTGYSLAMISALRGYRCIIAISDKSSHDKVEMLQALGAEVHLCPANVAPDDPRSYYEVAKRIHNETPNSIYVNQYFNPLNPESHYQTGREIWEQTQGEITHVVVCSGTGGTISGIAHYLKEQNPRVQVLGVDAYGSAIKKYHETREFDPAEVYPYKIEGIGKNLIPTATDFDVIDEFIKVTDKDAALMARKLARTEGLFMGYTSGAAIQAVKQYAEAGKFDENSIVVVLFADHGSRYMNKIYSDDWMKKQGFID", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more TrpB-like_PALP that are essential for its biological function; 2. The protein should belong to Cys_Synth/Cystath_Beta-Synth that shares evolutionary origin and functional similarity; 3. The protein should be classified within TrpB-like_PALP_sf, TrpB-like_PALP_sf, TrpB-like_PALP_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MKIDESLNVHSSLLQLIGNTPLLELHKITKGLKGRYFAKLEAFNVGHSAKDRVAKYIVEDAERKGLLKPGSTIVETSSGNTGYSLAMISALRGYRCIIAISDKSSHDKVEMLQALGAEVHLCPANVAPDDPRSYYEVAKRIHNETPNSIYVNQYFNPLNPESHYQTGREIWEQTQGEITHVVVCSGTGGTISGIAHYLKEQNPRVQVLGVDAYGSAIKKYHETREFDPAEVYPYKIEGIGKNLIPTATDFDVIDEFIKVTDKDAALMARKLARTEGLFMGYTSGAAIQAVKQYAEAGKFDENSIVVVLFADHGSRYMNKIYSDDWMKKQGFID" }, { "InterPro": [ { "InterPro-ID": "IPR036880", "InterPro-Name": "Kunitz_BPTI_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 86, "End": 147 }, { "InterPro-ID": "IPR036880", "InterPro-Name": "Kunitz_BPTI_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 23, "End": 155 } ], "response#1": "MHLPATIVFFTCTGVFSTTVFAKYRANPALCKVPIKSATGNCRNGNDLPSWLYGYNNITKKCVQYPTCFKRLAFESNEICLETCNKQSRCLQPPETGIFDIGWSTYYVYNSRKNMCKPVKKMKFRKTTSKQKNLFNSEEECQQECMPSTTPIYNVAQGTYPR", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should be classified within Kunitz_BPTI_sf, Kunitz_BPTI_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MHLPATIVFFTCTGVFSTTVFAKYRANPALCKVPIKSATGNCRNGNDLPSWLYGYNNITKKCVQYPTCFKRLAFESNEICLETCNKQSRCLQPPETGIFDIGWSTYYVYNSRKNMCKPVKKMKFRKTTSKQKNLFNSEEECQQECMPSTTPIYNVAQGTYPR" }, { "InterPro": [ { "InterPro-ID": "IPR002021", "InterPro-Name": "Paramyx_ncap", "InterPro-Type": "FAMILY", "Beg": 30, "End": 403 } ], "response#1": "MSSVLKAFERFTIEQELQDRGEEGSIPPETLKSAVKVFVINTPNPTTRYQMLNFCLRIICSQNARASHRVGALITLFSLPSAGMQNHIRLADRSPEAQIERCEIDGFEPGTYRLIPNARANLTANEIAAYALLADDLPPTINNGTPYVHADVEGQPCDEIEQFLDRCYSVLIQAWVMVCKCMTAYDQPAGSADRRFAKYQQQGRLEARYMLQPEAQRLIQTAIRKSLVVRQYLTFELQLARRQGLLSNRYYAMVGDIGKYIENSGLTAFFLTLKYALGTKWSPLSLAAFTGELTKLRSLMMLYRDIGEQARYLALLEAPQIMDFAPGGYPLIFSYAMGVGTVLDVQMRNYTYARPFLNGYYFQIGVETARRQQGTVDNRVADDLGLTPEQRTEVTQLVDRLARGRGAGIPGGPVNPFVPPVQQQQPAAVYEDIPALEESDDDGDEDGGAGFQNGVQVPAVRQGGQTDFRAQPLQDPIQAQLFMPLYPQVSNIPNNQNHQINRIGGLENQDLLRYNENGDSQQDARGEHGNTFPNNPNQNAQLQVGDWDE", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Paramyx_ncap that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MSSVLKAFERFTIEQELQDRGEEGSIPPETLKSAVKVFVINTPNPTTRYQMLNFCLRIICSQNARASHRVGALITLFSLPSAGMQNHIRLADRSPEAQIERCEIDGFEPGTYRLIPNARANLTANEIAAYALLADDLPPTINNGTPYVHADVEGQPCDEIEQFLDRCYSVLIQAWVMVCKCMTAYDQPAGSADRRFAKYQQQGRLEARYMLQPEAQRLIQTAIRKSLVVRQYLTFELQLARRQGLLSNRYYAMVGDIGKYIENSGLTAFFLTLKYALGTKWSPLSLAAFTGELTKLRSLMMLYRDIGEQARYLALLEAPQIMDFAPGGYPLIFSYAMGVGTVLDVQMRNYTYARPFLNGYYFQIGVETARRQQGTVDNRVADDLGLTPEQRTEVTQLVDRLARGRGAGIPGGPVNPFVPPVQQQQPAAVYEDIPALEESDDDGDEDGGAGFQNGVQVPAVRQGGQTDFRAQPLQDPIQAQLFMPLYPQVSNIPNNQNHQINRIGGLENQDLLRYNENGDSQQDARGEHGNTFPNNPNQNAQLQVGDWDE" }, { "InterPro": [ { "InterPro-ID": "IPR048925", "InterPro-Name": "RdfA", "InterPro-Type": "FAMILY", "Beg": 16, "End": 210 } ], "response#1": "MRDSGRSVSRRGGRGPKIERIANRYGLDGLGDDLVDAWLGDGRAQRSLRELEGDVNKRLIRAALDEAGAHVLDGEAENFYRLLTGDDVTAGSRTDARNTLRERGVDVEQLEADIISYQSVYNYLKRHRNVEREDDDDDETDATEAGLATIRKLRSRLRTVTIDVVDRLVKAERVFIGAYEVEVDIRVTCTDCDTRMTPTALLSSGHCDCERERDE", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to RdfA that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MRDSGRSVSRRGGRGPKIERIANRYGLDGLGDDLVDAWLGDGRAQRSLRELEGDVNKRLIRAALDEAGAHVLDGEAENFYRLLTGDDVTAGSRTDARNTLRERGVDVEQLEADIISYQSVYNYLKRHRNVEREDDDDDETDATEAGLATIRKLRSRLRTVTIDVVDRLVKAERVFIGAYEVEVDIRVTCTDCDTRMTPTALLSSGHCDCERERDE" }, { "InterPro": [ { "InterPro-ID": "IPR004358", "InterPro-Name": "Sig_transdc_His_kin-like_C", "InterPro-Type": "DOMAIN", "Beg": 343, "End": 356 }, { "InterPro-ID": "IPR004358", "InterPro-Name": "Sig_transdc_His_kin-like_C", "InterPro-Type": "DOMAIN", "Beg": 303, "End": 313 }, { "InterPro-ID": "IPR004358", "InterPro-Name": "Sig_transdc_His_kin-like_C", "InterPro-Type": "DOMAIN", "Beg": 320, "End": 338 }, { "InterPro-ID": "IPR004358", "InterPro-Name": "Sig_transdc_His_kin-like_C", "InterPro-Type": "DOMAIN", "Beg": 285, "End": 299 }, { "InterPro-ID": "IPR005467", "InterPro-Name": "His_kinase_dom", "InterPro-Type": "DOMAIN", "Beg": 144, "End": 359 }, { "InterPro-ID": "IPR003661", "InterPro-Name": "HisK_dim/P_dom", "InterPro-Type": "DOMAIN", "Beg": 135, "End": 200 }, { "InterPro-ID": "IPR050351", "InterPro-Name": "2-comp_sensor_kinase", "InterPro-Type": "FAMILY", "Beg": 106, "End": 357 }, { "InterPro-ID": "IPR036890", "InterPro-Name": "HATPase_C_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 194, "End": 357 }, { "InterPro-ID": "IPR003594", "InterPro-Name": "HATPase_dom", "InterPro-Type": "DOMAIN", "Beg": 249, "End": 359 }, { "InterPro-ID": "IPR036890", "InterPro-Name": "HATPase_C_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 205, "End": 360 }, { "InterPro-ID": "IPR003594", "InterPro-Name": "HATPase_dom", "InterPro-Type": "DOMAIN", "Beg": 250, "End": 357 }, { "InterPro-ID": "IPR003661", "InterPro-Name": "HisK_dim/P_dom", "InterPro-Type": "DOMAIN", "Beg": 137, "End": 204 }, { "InterPro-ID": "IPR003661", "InterPro-Name": "HisK_dim/P_dom", "InterPro-Type": "DOMAIN", "Beg": 138, "End": 200 }, { "InterPro-ID": "IPR036097", "InterPro-Name": "HisK_dim/P_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 125, "End": 202 } ], "response#1": "MKNRNPLIRKLLTQYFVTTGILLAFLVMIPLVIRFIAGTRTWYGTEPIYYILRFFADRWLFCVAIGALLIWFGTTIYYMTKAIGYLNETIQATTQLIEEPSKRITLSSHLIDVQEEMNQLREKSLQDQRAAKEAEQRKNDLIVYLAHDLRTPLTSVIGYLTLLKEEPQLSNAMRNRYTEIALQKAQRLELLISEFFEITRFNLTTIVLQTETTDLSLMLEQLTFEFLPLLEEKNLNWQLNLQKNVLATVDTEKIARVFDNLIRNAINYSYPDSPLLLELVESDSIHIRLTNRGKTIPEEMIGRLFEPFYRMDSSRATATSGTGLGLPIAKEILLASGGDISAESKDETIIFNVRLPKPANN", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Sig_transdc_His_kin-like_C, Sig_transdc_His_kin-like_C, Sig_transdc_His_kin-like_C, Sig_transdc_His_kin-like_C, His_kinase_dom, HisK_dim/P_dom, HATPase_dom, HATPase_dom, HisK_dim/P_dom, HisK_dim/P_dom that are essential for its biological function; 2. The protein should belong to 2-comp_sensor_kinase that shares evolutionary origin and functional similarity; 3. The protein should be classified within HATPase_C_sf, HATPase_C_sf, HisK_dim/P_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MKNRNPLIRKLLTQYFVTTGILLAFLVMIPLVIRFIAGTRTWYGTEPIYYILRFFADRWLFCVAIGALLIWFGTTIYYMTKAIGYLNETIQATTQLIEEPSKRITLSSHLIDVQEEMNQLREKSLQDQRAAKEAEQRKNDLIVYLAHDLRTPLTSVIGYLTLLKEEPQLSNAMRNRYTEIALQKAQRLELLISEFFEITRFNLTTIVLQTETTDLSLMLEQLTFEFLPLLEEKNLNWQLNLQKNVLATVDTEKIARVFDNLIRNAINYSYPDSPLLLELVESDSIHIRLTNRGKTIPEEMIGRLFEPFYRMDSSRATATSGTGLGLPIAKEILLASGGDISAESKDETIIFNVRLPKPANN" }, { "InterPro": [ { "InterPro-ID": "IPR002397", "InterPro-Name": "Cyt_P450_B", "InterPro-Type": "FAMILY", "Beg": 363, "End": 374 }, { "InterPro-ID": "IPR002397", "InterPro-Name": "Cyt_P450_B", "InterPro-Type": "FAMILY", "Beg": 103, "End": 114 }, { "InterPro-ID": "IPR002397", "InterPro-Name": "Cyt_P450_B", "InterPro-Type": "FAMILY", "Beg": 286, "End": 297 }, { "InterPro-ID": "IPR002397", "InterPro-Name": "Cyt_P450_B", "InterPro-Type": "FAMILY", "Beg": 150, "End": 166 }, { "InterPro-ID": "IPR002397", "InterPro-Name": "Cyt_P450_B", "InterPro-Type": "FAMILY", "Beg": 304, "End": 331 }, { "InterPro-ID": "IPR002397", "InterPro-Name": "Cyt_P450_B", "InterPro-Type": "FAMILY", "Beg": 167, "End": 182 }, { "InterPro-ID": "IPR002397", "InterPro-Name": "Cyt_P450_B", "InterPro-Type": "FAMILY", "Beg": 354, "End": 363 }, { "InterPro-ID": "IPR002397", "InterPro-Name": "Cyt_P450_B", "InterPro-Type": "FAMILY", "Beg": 332, "End": 347 }, { "InterPro-ID": "IPR002397", "InterPro-Name": "Cyt_P450_B", "InterPro-Type": "FAMILY", "Beg": 204, "End": 226 }, { "InterPro-ID": "IPR036396", "InterPro-Name": "Cyt_P450_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 27, "End": 414 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 203, "End": 383 }, { "InterPro-ID": "IPR017972", "InterPro-Name": "Cyt_P450_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 356, "End": 365 }, { "InterPro-ID": "IPR036396", "InterPro-Name": "Cyt_P450_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 14, "End": 414 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 286, "End": 297 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 354, "End": 363 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 363, "End": 374 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 249, "End": 266 } ], "response#1": "MSDTLASPSPETASGIPDYPMSRSAGCPFAPPPGVMALAAAKPLTRVRIWDGSTPWLITGYEQVRELFSDSRVSVDDRLPGFPHWNAGMLSTVHKRPRSVFTADGEEHTRFRRMLSKPFTFKRVEALRPTIQQITDEHIDAMLAGPQPADLVAKLALPVPSLVISQLLGVPYEDAEMFQHHANVGLARYATGADTVKGAMSLHKYLAELVEAKMANPAEDAVSDLAERVKAGELSVKEAAQLGTGLLIAGHETTANMIGLGVLALLVNPDQAGILRDAQDPKIVANAVEELLRYLSIIQNGQRRVAHEDIHIGGETIRAGEGIIIDLAPANWDAHAFTEPDRLYLHRAGAERNVAFGYGRHQCVGQQLARAELQIVYRTLLQRIPTLTLATALEDVPFKDDRLAYGVYELPVTW", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Cyt_P450_B, Cyt_P450_B, Cyt_P450_B, Cyt_P450_B, Cyt_P450_B, Cyt_P450_B, Cyt_P450_B, Cyt_P450_B, Cyt_P450_B, Cyt_P450, Cyt_P450, Cyt_P450, Cyt_P450, Cyt_P450 that shares evolutionary origin and functional similarity; 2. The protein should be classified within Cyt_P450_sf, Cyt_P450_sf sharing conserved structural features; 3. The protein should contain Cyt_P450_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MSDTLASPSPETASGIPDYPMSRSAGCPFAPPPGVMALAAAKPLTRVRIWDGSTPWLITGYEQVRELFSDSRVSVDDRLPGFPHWNAGMLSTVHKRPRSVFTADGEEHTRFRRMLSKPFTFKRVEALRPTIQQITDEHIDAMLAGPQPADLVAKLALPVPSLVISQLLGVPYEDAEMFQHHANVGLARYATGADTVKGAMSLHKYLAELVEAKMANPAEDAVSDLAERVKAGELSVKEAAQLGTGLLIAGHETTANMIGLGVLALLVNPDQAGILRDAQDPKIVANAVEELLRYLSIIQNGQRRVAHEDIHIGGETIRAGEGIIIDLAPANWDAHAFTEPDRLYLHRAGAERNVAFGYGRHQCVGQQLARAELQIVYRTLLQRIPTLTLATALEDVPFKDDRLAYGVYELPVTW" }, { "InterPro": [ { "InterPro-ID": "IPR001789", "InterPro-Name": "Sig_transdc_resp-reg_receiver", "InterPro-Type": "DOMAIN", "Beg": 4, "End": 117 }, { "InterPro-ID": "IPR001867", "InterPro-Name": "OmpR/PhoB-type_DNA-bd", "InterPro-Type": "DOMAIN", "Beg": 132, "End": 231 }, { "InterPro-ID": "IPR001789", "InterPro-Name": "Sig_transdc_resp-reg_receiver", "InterPro-Type": "DOMAIN", "Beg": 3, "End": 113 }, { "InterPro-ID": "IPR016032", "InterPro-Name": "Sig_transdc_resp-reg_C-effctor", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 134, "End": 229 }, { "InterPro-ID": "IPR001867", "InterPro-Name": "OmpR/PhoB-type_DNA-bd", "InterPro-Type": "DOMAIN", "Beg": 153, "End": 228 }, { "InterPro-ID": "IPR001867", "InterPro-Name": "OmpR/PhoB-type_DNA-bd", "InterPro-Type": "DOMAIN", "Beg": 140, "End": 229 }, { "InterPro-ID": "IPR001789", "InterPro-Name": "Sig_transdc_resp-reg_receiver", "InterPro-Type": "DOMAIN", "Beg": 5, "End": 113 }, { "InterPro-ID": "IPR011006", "InterPro-Name": "CheY-like_superfamily", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 3, "End": 126 }, { "InterPro-ID": "IPR036388", "InterPro-Name": "WH-like_DNA-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 125, "End": 231 }, { "InterPro-ID": "IPR039420", "InterPro-Name": "WalR-like", "InterPro-Type": "FAMILY", "Beg": 4, "End": 227 }, { "InterPro-ID": "IPR001867", "InterPro-Name": "OmpR/PhoB-type_DNA-bd", "InterPro-Type": "DOMAIN", "Beg": 153, "End": 229 } ], "response#1": "MSEKIVVVDDEKEIADLVTTFLQNEGFSVQPFYDGTSAIAYIEKEAIDLAVLDVMLPDIDGFQLLQQIRKTHFFPVLMLTAKGEDLDKITGLSLGADDYVTKPFNPLEVVARVKTQLRRYQRYNHSTASPTVEEYEKDGLILKINSHQCILYGKEVFLTPIEFKILLYLFEHQGSVVSSETLFEAVWKEKYLDNNNTVMAHIARLREKLHEEPRKPKLIKTVWGVGYIIEK", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Sig_transdc_resp-reg_receiver, OmpR/PhoB-type_DNA-bd, Sig_transdc_resp-reg_receiver, OmpR/PhoB-type_DNA-bd, OmpR/PhoB-type_DNA-bd, Sig_transdc_resp-reg_receiver, OmpR/PhoB-type_DNA-bd that are essential for its biological function; 2. The protein should belong to WalR-like that shares evolutionary origin and functional similarity; 3. The protein should be classified within Sig_transdc_resp-reg_C-effctor, CheY-like_superfamily, WH-like_DNA-bd_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MSEKIVVVDDEKEIADLVTTFLQNEGFSVQPFYDGTSAIAYIEKEAIDLAVLDVMLPDIDGFQLLQQIRKTHFFPVLMLTAKGEDLDKITGLSLGADDYVTKPFNPLEVVARVKTQLRRYQRYNHSTASPTVEEYEKDGLILKINSHQCILYGKEVFLTPIEFKILLYLFEHQGSVVSSETLFEAVWKEKYLDNNNTVMAHIARLREKLHEEPRKPKLIKTVWGVGYIIEK" }, { "InterPro": [ { "InterPro-ID": "IPR036388", "InterPro-Name": "WH-like_DNA-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1, "End": 88 }, { "InterPro-ID": "IPR000847", "InterPro-Name": "Tscrpt_reg_HTH_LysR", "InterPro-Type": "DOMAIN", "Beg": 1, "End": 58 }, { "InterPro-ID": "IPR000847", "InterPro-Name": "Tscrpt_reg_HTH_LysR", "InterPro-Type": "DOMAIN", "Beg": 3, "End": 61 }, { "InterPro-ID": "IPR005119", "InterPro-Name": "LysR_subst-bd", "InterPro-Type": "DOMAIN", "Beg": 91, "End": 287 }, { "InterPro-ID": "IPR036390", "InterPro-Name": "WH_DNA-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1, "End": 110 }, { "InterPro-ID": "IPR000847", "InterPro-Name": "Tscrpt_reg_HTH_LysR", "InterPro-Type": "DOMAIN", "Beg": 18, "End": 29 }, { "InterPro-ID": "IPR000847", "InterPro-Name": "Tscrpt_reg_HTH_LysR", "InterPro-Type": "DOMAIN", "Beg": 39, "End": 50 }, { "InterPro-ID": "IPR000847", "InterPro-Name": "Tscrpt_reg_HTH_LysR", "InterPro-Type": "DOMAIN", "Beg": 29, "End": 39 } ], "response#1": "MRLRHIEVFHAIYTTGSITNAAKALHVSQPSVSKVLSHAEMQLGFKLFERVKGRLIPTEEASMLFNEVDKIYQQMRSIKNTAENIKKAEFGNINLSVTPALGFDALPCAIAKYHHAYPKVNFNVQTIHNNEALQALLEHKCDLAVVFSPSAMPGVKAIKIAQSELVAVFPKRLFPSIPAQLTFQELEGAEFIDISDSGPLGHLLWKRMLEENIVLDSTIKVQTYFIAARLVAQGVGVCIVDKYTAMGNLSDDIAIASFSPPLFFNVSALHLENKVLSHVLDAFLNELSNCI", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Tscrpt_reg_HTH_LysR, Tscrpt_reg_HTH_LysR, LysR_subst-bd, Tscrpt_reg_HTH_LysR, Tscrpt_reg_HTH_LysR, Tscrpt_reg_HTH_LysR that are essential for its biological function; 2. The protein should be classified within WH-like_DNA-bd_sf, WH_DNA-bd_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MRLRHIEVFHAIYTTGSITNAAKALHVSQPSVSKVLSHAEMQLGFKLFERVKGRLIPTEEASMLFNEVDKIYQQMRSIKNTAENIKKAEFGNINLSVTPALGFDALPCAIAKYHHAYPKVNFNVQTIHNNEALQALLEHKCDLAVVFSPSAMPGVKAIKIAQSELVAVFPKRLFPSIPAQLTFQELEGAEFIDISDSGPLGHLLWKRMLEENIVLDSTIKVQTYFIAARLVAQGVGVCIVDKYTAMGNLSDDIAIASFSPPLFFNVSALHLENKVLSHVLDAFLNELSNCI" }, { "InterPro": [ { "InterPro-ID": "IPR013783", "InterPro-Name": "Ig-like_fold", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 627, "End": 721 }, { "InterPro-ID": "IPR003961", "InterPro-Name": "FN3_dom", "InterPro-Type": "DOMAIN", "Beg": 628, "End": 717 }, { "InterPro-ID": "IPR032876", "InterPro-Name": "J_dom", "InterPro-Type": "DOMAIN", "Beg": 340, "End": 488 }, { "InterPro-ID": "IPR015406", "InterPro-Name": "GpJ_CSF", "InterPro-Type": "DOMAIN", "Beg": 1036, "End": 1165 }, { "InterPro-ID": "IPR013783", "InterPro-Name": "Ig-like_fold", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 724, "End": 824 }, { "InterPro-ID": "IPR053171", "InterPro-Name": "Viral_Tip_Attach_Protein", "InterPro-Type": "FAMILY", "Beg": 2, "End": 872 }, { "InterPro-ID": "IPR055385", "InterPro-Name": "GpJ_HDII-ins2", "InterPro-Type": "DOMAIN", "Beg": 92, "End": 217 }, { "InterPro-ID": "IPR003961", "InterPro-Name": "FN3_dom", "InterPro-Type": "DOMAIN", "Beg": 628, "End": 722 }, { "InterPro-ID": "IPR003961", "InterPro-Name": "FN3_dom", "InterPro-Type": "DOMAIN", "Beg": 727, "End": 821 }, { "InterPro-ID": "IPR036116", "InterPro-Name": "FN3_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 626, "End": 717 } ], "response#1": "MAKYMISGSKGGSKKPYVPKEMEDNLISINKIKVLLAVSDGECDPDFTLRDLYLDDVPVIASDGTVNYEGVTAEYRPGTQTQDYIQGFTDTSSEVTVARDITGDNPYVISVTNKNLSAVRIKILMPVGIKTEDNGDLVGVRVEYAVDMAIDGGSYSEVMRDVIDGKTRSGYDRSRRIDLPKFDERVLIRVKRLTPDSTSSKVTDKIKLQSYAEVVDAKFRYPLTGLVFVEFDSELFPTQIPNISIKKKWKIINVPSNYDPISREYHGSWDGTFKKAWSNNPAWVLYDLVTNQRYGLDQRELGIQIDKWSLYEAGVYCDQKVPDGKGGTEPRYLCDVVIQNQVEAYQLIRDICSIFRGMSFWNGESLSIVIDKPRDPSYVFTNENVINGDFQYTTASEKSMYTQCNVTFDDEQNMYQQDVEGVFDTEAALRFGYNPTSITAIGCTRRSEANRRGRWVLKTNLRSTTVNFATGLEGMIPSIGDVIAIADNFQSSNLTLNLSGRVMEVSGLQVFVPFKVDARPGDFIIINKPDGKPVKRTISKVSADGKTIELNIGFGFDVKPDTVFAIDRTDLALQQYVVTTISKGDDENEFTYSITAVEYDPNKYDEIDYGVNIDDRPTSIVQPDVMAAPENVKISSYSRVVQGVSVETMVVSWDKVPYASLYEMQWRKGDGNWLNTPQTANKEIEVEGIYSGNYQVRVRSVSASGNASPWSKIATATLTGKVGEPGAPINLTASDNEVFGIRVKWGMPEGSGDTAYIELHQSPDGTVENSSLLTLIPYPQYEYWHSTLPAGQVVWYRIRSVDRIGNVSSWTDFVRGMASDDVESVLGDILDKIFDTEAGQEIKENAIDSANKIKDQAQSIIQNALANDADVKWTRVQNGKRKAEYGHALELIANETEARVTQIEELRASIDGEITSSIKTVQEAIATESETRATQIQQLDSKFTKEIDGVRKDTSASISDVRQTITNESEARAQAVQQLDAKFTKEINDLDGVIKTEVEANISEVKQAIANETEARVQADQALTARFGDVESALVEKLDSWASVDSVGAKYAMKLGLTYKGQQYSAGMVMQLSQGSSGLISQILFDANRFAIMTSSTGGTFTLPFVVENNQVFINSLLVKNGSITNAMIGNVIQSNNFVQNQQGWRLDKNGIFENYGSTPGEGATKFTNEGLKVKDANGVLRVEVGRITGSW", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more FN3_dom, J_dom, GpJ_CSF, GpJ_HDII-ins2, FN3_dom, FN3_dom that are essential for its biological function; 2. The protein should belong to Viral_Tip_Attach_Protein that shares evolutionary origin and functional similarity; 3. The protein should be classified within Ig-like_fold, Ig-like_fold, FN3_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MAKYMISGSKGGSKKPYVPKEMEDNLISINKIKVLLAVSDGECDPDFTLRDLYLDDVPVIASDGTVNYEGVTAEYRPGTQTQDYIQGFTDTSSEVTVARDITGDNPYVISVTNKNLSAVRIKILMPVGIKTEDNGDLVGVRVEYAVDMAIDGGSYSEVMRDVIDGKTRSGYDRSRRIDLPKFDERVLIRVKRLTPDSTSSKVTDKIKLQSYAEVVDAKFRYPLTGLVFVEFDSELFPTQIPNISIKKKWKIINVPSNYDPISREYHGSWDGTFKKAWSNNPAWVLYDLVTNQRYGLDQRELGIQIDKWSLYEAGVYCDQKVPDGKGGTEPRYLCDVVIQNQVEAYQLIRDICSIFRGMSFWNGESLSIVIDKPRDPSYVFTNENVINGDFQYTTASEKSMYTQCNVTFDDEQNMYQQDVEGVFDTEAALRFGYNPTSITAIGCTRRSEANRRGRWVLKTNLRSTTVNFATGLEGMIPSIGDVIAIADNFQSSNLTLNLSGRVMEVSGLQVFVPFKVDARPGDFIIINKPDGKPVKRTISKVSADGKTIELNIGFGFDVKPDTVFAIDRTDLALQQYVVTTISKGDDENEFTYSITAVEYDPNKYDEIDYGVNIDDRPTSIVQPDVMAAPENVKISSYSRVVQGVSVETMVVSWDKVPYASLYEMQWRKGDGNWLNTPQTANKEIEVEGIYSGNYQVRVRSVSASGNASPWSKIATATLTGKVGEPGAPINLTASDNEVFGIRVKWGMPEGSGDTAYIELHQSPDGTVENSSLLTLIPYPQYEYWHSTLPAGQVVWYRIRSVDRIGNVSSWTDFVRGMASDDVESVLGDILDKIFDTEAGQEIKENAIDSANKIKDQAQSIIQNALANDADVKWTRVQNGKRKAEYGHALELIANETEARVTQIEELRASIDGEITSSIKTVQEAIATESETRATQIQQLDSKFTKEIDGVRKDTSASISDVRQTITNESEARAQAVQQLDAKFTKEINDLDGVIKTEVEANISEVKQAIANETEARVQADQALTARFGDVESALVEKLDSWASVDSVGAKYAMKLGLTYKGQQYSAGMVMQLSQGSSGLISQILFDANRFAIMTSSTGGTFTLPFVVENNQVFINSLLVKNGSITNAMIGNVIQSNNFVQNQQGWRLDKNGIFENYGSTPGEGATKFTNEGLKVKDANGVLRVEVGRITGSW" }, { "InterPro": [ { "InterPro-ID": "IPR045296", "InterPro-Name": "Complex1_LYR_ETFRF1_LYRM5", "InterPro-Type": "DOMAIN", "Beg": 5, "End": 80 }, { "InterPro-ID": "IPR052000", "InterPro-Name": "ETFRF1", "InterPro-Type": "FAMILY", "Beg": 2, "End": 83 }, { "InterPro-ID": "IPR008011", "InterPro-Name": "Complex1_LYR_dom", "InterPro-Type": "DOMAIN", "Beg": 7, "End": 60 } ], "response#1": "MSQLRSKVISLYKHLQYLGREYPGLNGPQKFRKQIHDAFMNHKDEQDPKKIVALLAQGRYLAKEVEALYSLKKYRSVKQRYSYND", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Complex1_LYR_ETFRF1_LYRM5, Complex1_LYR_dom that are essential for its biological function; 2. The protein should belong to ETFRF1 that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MSQLRSKVISLYKHLQYLGREYPGLNGPQKFRKQIHDAFMNHKDEQDPKKIVALLAQGRYLAKEVEALYSLKKYRSVKQRYSYND" }, { "InterPro": [ { "InterPro-ID": "IPR000424", "InterPro-Name": "Primosome_PriB/ssb", "InterPro-Type": "FAMILY", "Beg": 6, "End": 111 }, { "InterPro-ID": "IPR011344", "InterPro-Name": "ssDNA-bd", "InterPro-Type": "FAMILY", "Beg": 6, "End": 117 }, { "InterPro-ID": "IPR011344", "InterPro-Name": "ssDNA-bd", "InterPro-Type": "FAMILY", "Beg": 3, "End": 146 }, { "InterPro-ID": "IPR000424", "InterPro-Name": "Primosome_PriB/ssb", "InterPro-Type": "FAMILY", "Beg": 9, "End": 105 }, { "InterPro-ID": "IPR012340", "InterPro-Name": "NA-bd_OB-fold", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 4, "End": 174 }, { "InterPro-ID": "IPR012340", "InterPro-Name": "NA-bd_OB-fold", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 2, "End": 143 }, { "InterPro-ID": "IPR011344", "InterPro-Name": "ssDNA-bd", "InterPro-Type": "FAMILY", "Beg": 4, "End": 174 }, { "InterPro-ID": "IPR011344", "InterPro-Name": "ssDNA-bd", "InterPro-Type": "FAMILY", "Beg": 2, "End": 157 }, { "InterPro-ID": "IPR000424", "InterPro-Name": "Primosome_PriB/ssb", "InterPro-Type": "FAMILY", "Beg": 6, "End": 112 } ], "response#1": "MASRGVNKVILVGNLGQDPEVRYMPSGGAVANFTLATSESWRDKQTGEMKEQTEWHRVVLFGKLAEVAGEYLRKGSQVYIEGQLRTRKWTDQSGQDKYTTEVVVNVGGTMQMLGGRQGGGAPAGGGQQQGGWGQPQQPQGGNQFSGGAQSRPQQQAPAAPSNEPPMDFDDDIPF", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Primosome_PriB/ssb, ssDNA-bd, ssDNA-bd, Primosome_PriB/ssb, ssDNA-bd, ssDNA-bd, Primosome_PriB/ssb that shares evolutionary origin and functional similarity; 2. The protein should be classified within NA-bd_OB-fold, NA-bd_OB-fold sharing conserved structural features. The designed protein sequence is ", "reference": "MASRGVNKVILVGNLGQDPEVRYMPSGGAVANFTLATSESWRDKQTGEMKEQTEWHRVVLFGKLAEVAGEYLRKGSQVYIEGQLRTRKWTDQSGQDKYTTEVVVNVGGTMQMLGGRQGGGAPAGGGQQQGGWGQPQQPQGGNQFSGGAQSRPQQQAPAAPSNEPPMDFDDDIPF" }, { "InterPro": [ { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 10, "End": 306 }, { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 435, "End": 642 }, { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 12, "End": 256 }, { "InterPro-ID": "IPR038729", "InterPro-Name": "Rad50/SbcC_AAA", "InterPro-Type": "DOMAIN", "Beg": 12, "End": 226 } ], "response#1": "MNDSEALQAATVRIRNIGGIDERRVRLDPGVTVLTGRNATNRTSFLRALMGACGSDAISLKGDADEGSVELELDGRTYTRLLSRENGTVSTDGTPYLRDAATADRFAFLLGSNEARRAVVAERDLYDVIMSLVDTDAIEAEIERLQSRRTQVERRLDSLDSLDADRRSLESKRDDLEAEIEALEAERDDIEAEIEAEDRTVETQREHQAELDEVLSELQSARSDLESVRFRLQSERESVESLREERSELQSELDSFDAEAVDRGEASDRIESVRSRIESLNSTISELQTVVQYTEDVLDGKAGLVEDSLGADGDGSVTDQLVSSETTTCWTCGTEVDRDQIRGTTDRLREVRDEKREERAELRRELDELERSMRAAEQAERDRRKLRDKLRRLEDELDRRTGQIESLTDRREELAEQVDALEADASELRGQSGGEGDLIELHRELNEVEFALDRTRDDLASVHDELDELDDRFDEREELEREREQVNEELEAARTRIRSLTAAAVESFNEEMETVLDLLGYDNIERVWLERVERRVREGRRKVEKAQFELHIVRASDSGAVYEDSIDHLSESEREVVGLVFALAGYLVHEVYEEVPFMLLDSVEAIDAGRIAALVDHFEQYPTFLVAALLPEDAQALDASYRRVTWGTDVTPAA", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Rad50/SbcC_AAA that are essential for its biological function; 2. The protein should be classified within P-loop_NTPase, P-loop_NTPase, P-loop_NTPase sharing conserved structural features. The designed protein sequence is ", "reference": "MNDSEALQAATVRIRNIGGIDERRVRLDPGVTVLTGRNATNRTSFLRALMGACGSDAISLKGDADEGSVELELDGRTYTRLLSRENGTVSTDGTPYLRDAATADRFAFLLGSNEARRAVVAERDLYDVIMSLVDTDAIEAEIERLQSRRTQVERRLDSLDSLDADRRSLESKRDDLEAEIEALEAERDDIEAEIEAEDRTVETQREHQAELDEVLSELQSARSDLESVRFRLQSERESVESLREERSELQSELDSFDAEAVDRGEASDRIESVRSRIESLNSTISELQTVVQYTEDVLDGKAGLVEDSLGADGDGSVTDQLVSSETTTCWTCGTEVDRDQIRGTTDRLREVRDEKREERAELRRELDELERSMRAAEQAERDRRKLRDKLRRLEDELDRRTGQIESLTDRREELAEQVDALEADASELRGQSGGEGDLIELHRELNEVEFALDRTRDDLASVHDELDELDDRFDEREELEREREQVNEELEAARTRIRSLTAAAVESFNEEMETVLDLLGYDNIERVWLERVERRVREGRRKVEKAQFELHIVRASDSGAVYEDSIDHLSESEREVVGLVFALAGYLVHEVYEEVPFMLLDSVEAIDAGRIAALVDHFEQYPTFLVAALLPEDAQALDASYRRVTWGTDVTPAA" }, { "InterPro": [ { "InterPro-ID": "IPR035903", "InterPro-Name": "HesB-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 44, "End": 141 }, { "InterPro-ID": "IPR000361", "InterPro-Name": "FeS_biogenesis", "InterPro-Type": "DOMAIN", "Beg": 50, "End": 153 }, { "InterPro-ID": "IPR016092", "InterPro-Name": "FeS_cluster_insertion", "InterPro-Type": "FAMILY", "Beg": 50, "End": 156 }, { "InterPro-ID": "IPR035903", "InterPro-Name": "HesB-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 49, "End": 160 } ], "response#1": "MLKFLSTKCKQFNSLNHIIKHKIYFPSKSNKSYFSSSVKDVEKKNKEPIIQLTNDAINKMKEINLKYKNSKALKVCVEAGGCSGFQYSFSLIDKNKIKDKEQIVYDKDCIVVIDKQVIDILKNSKIHYINNLISKKFTIENIQNISSKCSCGNSFDIDFV", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more FeS_biogenesis that are essential for its biological function; 2. The protein should belong to FeS_cluster_insertion that shares evolutionary origin and functional similarity; 3. The protein should be classified within HesB-like_dom_sf, HesB-like_dom_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MLKFLSTKCKQFNSLNHIIKHKIYFPSKSNKSYFSSSVKDVEKKNKEPIIQLTNDAINKMKEINLKYKNSKALKVCVEAGGCSGFQYSFSLIDKNKIKDKEQIVYDKDCIVVIDKQVIDILKNSKIHYINNLISKKFTIENIQNISSKCSCGNSFDIDFV" }, { "InterPro": [ { "InterPro-ID": "IPR007275", "InterPro-Name": "YTH_domain", "InterPro-Type": "DOMAIN", "Beg": 511, "End": 577 }, { "InterPro-ID": "IPR007275", "InterPro-Name": "YTH_domain", "InterPro-Type": "DOMAIN", "Beg": 435, "End": 576 } ], "response#1": "MWPNLFWGFDAYDGSNFNAFPIYFPTEFMQTEPRDQSSCQQLSMEQATEPSMNPDQEDIVEGGENYGELSNQQETVPSFENADQNLSRLEMSTLARELKEKVKQSRALRQSVNNAAEQQPSTKPQPVQQEVQDLINDILKSQDQDDNLKNPSKLTGPQDDTETEKPASTLPTTPRTIKESPLSTYSIPVYCPASPEGRTHIPDEILDNAPKGPRHTHRGQVQMFCNGECGRRETDKAMPAIEPSDKTEETEGATAVRIPPVATDGDLEQDVIMWLRHTGFYDKAKRTDALARWKQLAKMEQGLARPQQDHQEAGVALASASQGSKEAGMGTRPGPDADCPPVCRPEQGGPGSSQAALSCKSKQSTDIQRATLAETRGGSLRDRAANQQPSKKSDRGRCARRHRSSSPRGRSGSHKSRRATTDSPVSRSTTKSTPSRARQPGHRDYREYRDDRNRDTKPRSPLVSCRAAVAFNPGVKGAPLVRQRFRPRQTNTDLQHKARIVGAPPRDMESNIKERQNHDPERQSGQFGIRWLCTSPLALQNTKSLRNSFDDLKPVLLGRDGQEMDDYCGRDLLRLMDASERGLHRP", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more YTH_domain, YTH_domain that are essential for its biological function. The designed protein sequence is ", "reference": "MWPNLFWGFDAYDGSNFNAFPIYFPTEFMQTEPRDQSSCQQLSMEQATEPSMNPDQEDIVEGGENYGELSNQQETVPSFENADQNLSRLEMSTLARELKEKVKQSRALRQSVNNAAEQQPSTKPQPVQQEVQDLINDILKSQDQDDNLKNPSKLTGPQDDTETEKPASTLPTTPRTIKESPLSTYSIPVYCPASPEGRTHIPDEILDNAPKGPRHTHRGQVQMFCNGECGRRETDKAMPAIEPSDKTEETEGATAVRIPPVATDGDLEQDVIMWLRHTGFYDKAKRTDALARWKQLAKMEQGLARPQQDHQEAGVALASASQGSKEAGMGTRPGPDADCPPVCRPEQGGPGSSQAALSCKSKQSTDIQRATLAETRGGSLRDRAANQQPSKKSDRGRCARRHRSSSPRGRSGSHKSRRATTDSPVSRSTTKSTPSRARQPGHRDYREYRDDRNRDTKPRSPLVSCRAAVAFNPGVKGAPLVRQRFRPRQTNTDLQHKARIVGAPPRDMESNIKERQNHDPERQSGQFGIRWLCTSPLALQNTKSLRNSFDDLKPVLLGRDGQEMDDYCGRDLLRLMDASERGLHRP" }, { "InterPro": [ { "InterPro-ID": "IPR002052", "InterPro-Name": "DNA_methylase_N6_adenine_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 183, "End": 189 }, { "InterPro-ID": "IPR007757", "InterPro-Name": "MT-A70-like", "InterPro-Type": "FAMILY", "Beg": 180, "End": 353 }, { "InterPro-ID": "IPR007757", "InterPro-Name": "MT-A70-like", "InterPro-Type": "FAMILY", "Beg": 139, "End": 374 }, { "InterPro-ID": "IPR029063", "InterPro-Name": "SAM-dependent_MTases_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 179, "End": 306 } ], "response#1": "MTAATLFESTDGTVVLLDLPRSIEDAQQHPAAVTLPEAPSLVTNSCRDGTSWTRRLISSPPPETPFVTPEPKNGPSPLPAAAQVAQLMIQASVTGALEELRTNYSGPYLLPRQLSPQRMIADGGKAVDDYKSPHACDLESCSTTAEDATKGRYYFPPESHHVLGTIQETKTLLLQSAPNFNVIVLDPPWPNRSAKRKKGGYKVATTTDDIRALLSDVPIPSLLARDGLVAIWVTNKPAFLDMLTSPRDGILSEWGLELVGEWSWLKITTSAEPILPIDSAHRKPWEPLLIAQRKGSKRVFPPFWRRRVIVSVPDTHSRKPNIRDLVNPMLPPRSRGLEIFARNLTAGWWAWGDDVLHFQERSNWVMAESKSPATGC", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to MT-A70-like, MT-A70-like that shares evolutionary origin and functional similarity; 2. The protein should be classified within SAM-dependent_MTases_sf sharing conserved structural features; 3. The protein should contain DNA_methylase_N6_adenine_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MTAATLFESTDGTVVLLDLPRSIEDAQQHPAAVTLPEAPSLVTNSCRDGTSWTRRLISSPPPETPFVTPEPKNGPSPLPAAAQVAQLMIQASVTGALEELRTNYSGPYLLPRQLSPQRMIADGGKAVDDYKSPHACDLESCSTTAEDATKGRYYFPPESHHVLGTIQETKTLLLQSAPNFNVIVLDPPWPNRSAKRKKGGYKVATTTDDIRALLSDVPIPSLLARDGLVAIWVTNKPAFLDMLTSPRDGILSEWGLELVGEWSWLKITTSAEPILPIDSAHRKPWEPLLIAQRKGSKRVFPPFWRRRVIVSVPDTHSRKPNIRDLVNPMLPPRSRGLEIFARNLTAGWWAWGDDVLHFQERSNWVMAESKSPATGC" }, { "InterPro": [ { "InterPro-ID": "IPR007275", "InterPro-Name": "YTH_domain", "InterPro-Type": "DOMAIN", "Beg": 383, "End": 590 }, { "InterPro-ID": "IPR035979", "InterPro-Name": "RBD_domain_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 222, "End": 307 }, { "InterPro-ID": "IPR000504", "InterPro-Name": "RRM_dom", "InterPro-Type": "DOMAIN", "Beg": 242, "End": 310 }, { "InterPro-ID": "IPR045168", "InterPro-Name": "YTH_prot", "InterPro-Type": "FAMILY", "Beg": 16, "End": 592 }, { "InterPro-ID": "IPR012677", "InterPro-Name": "Nucleotide-bd_a/b_plait_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 232, "End": 310 }, { "InterPro-ID": "IPR007275", "InterPro-Name": "YTH_domain", "InterPro-Type": "DOMAIN", "Beg": 382, "End": 590 } ], "response#1": "MGDAPLPPGSGKEFTQVQQQHNNYSNHQQQHAFASQYDMTQQQQPFGRGLSGPYNMGLMMHALPHPSYRPGQQQQHQYGSPPNTNGNAQPMPQAHGNNTMNSMPGPPQYYMQQQHGLPPQYYAQQMQGSQQQQQHQRGSMSPRANMALYQQPHTQGQQYYYPQGAQFPNHGPMPQNSMLAGPYPLASHMQHVDHRLAQRQVGDQRDVDNTEQSQPRVDGARFESQSNVVRGPPRKPRQSGHAIWIGNLPPQTDLMSLVYHVCKEAPGLESLFLISKSNCAFANFKDEEACISAQQKIHDSKFQTVRLVSRLRKSTVEGATGLTAPTGPAASAPQSNISQEVKGDALSVVTTTEDLIASSNVSSPKVTSPAPVETDRSAPQKEKYFILKSLTVEDLEQSIKTGIWATQAHNEKALNKAYETAESVYLIFSANKSGEYFGYARMTSQINEDPAAAVEFAPKAQAASDVALPKAIPTEANEYMPKGSIMDDSERGTIFWEADPPEDADGVDSNDTTTAAVADDTVSIKSCETGGPDSKVWGKPFQIEWLSVARLPFYRTRGIRNPWNSNREVKIARDGTELEPSVGRKLTGLFTSRGVGQLQQQPHPHHHHVMGGGMPMPGGMVHGYPPMYAQ", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more YTH_domain, RRM_dom, YTH_domain that are essential for its biological function; 2. The protein should belong to YTH_prot that shares evolutionary origin and functional similarity; 3. The protein should be classified within RBD_domain_sf, Nucleotide-bd_a/b_plait_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MGDAPLPPGSGKEFTQVQQQHNNYSNHQQQHAFASQYDMTQQQQPFGRGLSGPYNMGLMMHALPHPSYRPGQQQQHQYGSPPNTNGNAQPMPQAHGNNTMNSMPGPPQYYMQQQHGLPPQYYAQQMQGSQQQQQHQRGSMSPRANMALYQQPHTQGQQYYYPQGAQFPNHGPMPQNSMLAGPYPLASHMQHVDHRLAQRQVGDQRDVDNTEQSQPRVDGARFESQSNVVRGPPRKPRQSGHAIWIGNLPPQTDLMSLVYHVCKEAPGLESLFLISKSNCAFANFKDEEACISAQQKIHDSKFQTVRLVSRLRKSTVEGATGLTAPTGPAASAPQSNISQEVKGDALSVVTTTEDLIASSNVSSPKVTSPAPVETDRSAPQKEKYFILKSLTVEDLEQSIKTGIWATQAHNEKALNKAYETAESVYLIFSANKSGEYFGYARMTSQINEDPAAAVEFAPKAQAASDVALPKAIPTEANEYMPKGSIMDDSERGTIFWEADPPEDADGVDSNDTTTAAVADDTVSIKSCETGGPDSKVWGKPFQIEWLSVARLPFYRTRGIRNPWNSNREVKIARDGTELEPSVGRKLTGLFTSRGVGQLQQQPHPHHHHVMGGGMPMPGGMVHGYPPMYAQ" }, { "InterPro": [ { "InterPro-ID": "IPR035903", "InterPro-Name": "HesB-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 265, "End": 400 }, { "InterPro-ID": "IPR000361", "InterPro-Name": "FeS_biogenesis", "InterPro-Type": "DOMAIN", "Beg": 310, "End": 395 }, { "InterPro-ID": "IPR050322", "InterPro-Name": "Fe-S_cluster_asmbl/transfer", "InterPro-Type": "FAMILY", "Beg": 256, "End": 399 }, { "InterPro-ID": "IPR017870", "InterPro-Name": "FeS_cluster_insertion_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 381, "End": 398 }, { "InterPro-ID": "IPR016092", "InterPro-Name": "FeS_cluster_insertion", "InterPro-Type": "FAMILY", "Beg": 310, "End": 399 }, { "InterPro-ID": "IPR035903", "InterPro-Name": "HesB-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 263, "End": 386 } ], "response#1": "MFNNFLNMYMCTLAEKLCKFKKNNFNNIHRNNNFYRDNNFYRDNNFYRDNNFYRDNNFYRDNNLYTNNNLYRDNNFYRDNNFYRDNNFYRDNNLYTNNNLYRDNNLYTNNNLYRDNNFYNITLRKFHFIQTISNNNFNFEIIKKYGDVINKIMFIHTQKKNKQERFMFNNKKYIKRKEYILNDLNEFISIIPHPEINNEITNNSNQKKNKDNKQNVLSTNQQIITNYNLNHKENVTSNLNFNNKEEDEKKLDKLLKKRNIKKRDIVTITEEAKEELKKIISINKKENNNNYNNMNTICSDNHNDMNTICNDKNILKLFFITKGCNGLTHSFNFISKKDIHKEDEIIYDDQNNILLVIDKNCILYVINTTLDYYKDDLTEKFIFKNPNITSICPCGTSFHFSKKK", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more FeS_biogenesis that are essential for its biological function; 2. The protein should belong to Fe-S_cluster_asmbl/transfer, FeS_cluster_insertion that shares evolutionary origin and functional similarity; 3. The protein should be classified within HesB-like_dom_sf, HesB-like_dom_sf sharing conserved structural features; 4. The protein should contain FeS_cluster_insertion_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MFNNFLNMYMCTLAEKLCKFKKNNFNNIHRNNNFYRDNNFYRDNNFYRDNNFYRDNNFYRDNNLYTNNNLYRDNNFYRDNNFYRDNNFYRDNNLYTNNNLYRDNNLYTNNNLYRDNNFYNITLRKFHFIQTISNNNFNFEIIKKYGDVINKIMFIHTQKKNKQERFMFNNKKYIKRKEYILNDLNEFISIIPHPEINNEITNNSNQKKNKDNKQNVLSTNQQIITNYNLNHKENVTSNLNFNNKEEDEKKLDKLLKKRNIKKRDIVTITEEAKEELKKIISINKKENNNNYNNMNTICSDNHNDMNTICNDKNILKLFFITKGCNGLTHSFNFISKKDIHKEDEIIYDDQNNILLVIDKNCILYVINTTLDYYKDDLTEKFIFKNPNITSICPCGTSFHFSKKK" }, { "InterPro": [ { "InterPro-ID": "IPR006058", "InterPro-Name": "2Fe2S_fd_BS", "InterPro-Type": "BINDING_SITE", "Beg": 303, "End": 311 }, { "InterPro-ID": "IPR001041", "InterPro-Name": "2Fe-2S_ferredoxin-type", "InterPro-Type": "DOMAIN", "Beg": 269, "End": 353 }, { "InterPro-ID": "IPR008333", "InterPro-Name": "Cbr1-like_FAD-bd_dom", "InterPro-Type": "DOMAIN", "Beg": 22, "End": 111 }, { "InterPro-ID": "IPR050415", "InterPro-Name": "MRET", "InterPro-Type": "FAMILY", "Beg": 15, "End": 306 }, { "InterPro-ID": "IPR039261", "InterPro-Name": "FNR_nucleotide-bd", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 113, "End": 251 }, { "InterPro-ID": "IPR001041", "InterPro-Name": "2Fe-2S_ferredoxin-type", "InterPro-Type": "DOMAIN", "Beg": 276, "End": 345 }, { "InterPro-ID": "IPR001433", "InterPro-Name": "OxRdtase_FAD/NAD-bd", "InterPro-Type": "DOMAIN", "Beg": 123, "End": 229 }, { "InterPro-ID": "IPR001041", "InterPro-Name": "2Fe-2S_ferredoxin-type", "InterPro-Type": "DOMAIN", "Beg": 270, "End": 352 }, { "InterPro-ID": "IPR012675", "InterPro-Name": "Beta-grasp_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 252, "End": 353 }, { "InterPro-ID": "IPR039261", "InterPro-Name": "FNR_nucleotide-bd", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 102, "End": 245 }, { "InterPro-ID": "IPR017938", "InterPro-Name": "Riboflavin_synthase-like_b-brl", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 10, "End": 111 }, { "InterPro-ID": "IPR036010", "InterPro-Name": "2Fe-2S_ferredoxin-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 238, "End": 352 }, { "InterPro-ID": "IPR017927", "InterPro-Name": "FAD-bd_FR_type", "InterPro-Type": "DOMAIN", "Beg": 11, "End": 114 } ], "response#1": "MTQFKQLSFWSDAEPLECVTRTPEAPNVVTFSFQSPSGALFNHDPGQFVTLELPAPGGPLYRTYTISSAPSRPTALTITVKAQDGSTGTRWMLDNLHKGMRIRAIGPAGKFSIVHHPADKYLFISAGSGITPMVAMTTWLYDSGREPDVVFINCARRPSEIILRDRMELMASRIVGIDLKWVVEEPDPFRSWTGYRGMFNQIMLGLMAQDYLEREVFCCGPEPFMRAVREALAGLGYDMSRYHQESFTAEPGHAEDVPEDVIPDEQNHAEIAFALSGVTTRCSETDTILAAAKAAGLVIPSGCSMGICGTCKVRKTEGQVHMVHNGGITDEDVEDGYILACCSKPLRRVSVEA", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more 2Fe-2S_ferredoxin-type, Cbr1-like_FAD-bd_dom, 2Fe-2S_ferredoxin-type, OxRdtase_FAD/NAD-bd, 2Fe-2S_ferredoxin-type, FAD-bd_FR_type that are essential for its biological function; 2. The protein should belong to MRET that shares evolutionary origin and functional similarity; 3. The protein should be classified within FNR_nucleotide-bd, Beta-grasp_dom_sf, FNR_nucleotide-bd, Riboflavin_synthase-like_b-brl, 2Fe-2S_ferredoxin-like_sf sharing conserved structural features; 4. The protein should include a 2Fe2S_fd_BS that enables ligand binding under diverse conditions. The designed protein sequence is ", "reference": "MTQFKQLSFWSDAEPLECVTRTPEAPNVVTFSFQSPSGALFNHDPGQFVTLELPAPGGPLYRTYTISSAPSRPTALTITVKAQDGSTGTRWMLDNLHKGMRIRAIGPAGKFSIVHHPADKYLFISAGSGITPMVAMTTWLYDSGREPDVVFINCARRPSEIILRDRMELMASRIVGIDLKWVVEEPDPFRSWTGYRGMFNQIMLGLMAQDYLEREVFCCGPEPFMRAVREALAGLGYDMSRYHQESFTAEPGHAEDVPEDVIPDEQNHAEIAFALSGVTTRCSETDTILAAAKAAGLVIPSGCSMGICGTCKVRKTEGQVHMVHNGGITDEDVEDGYILACCSKPLRRVSVEA" }, { "InterPro": [ { "InterPro-ID": "IPR008949", "InterPro-Name": "Isoprenoid_synthase_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 3, "End": 349 }, { "InterPro-ID": "IPR024652", "InterPro-Name": "Trichodiene_synth", "InterPro-Type": "FAMILY", "Beg": 6, "End": 316 }, { "InterPro-ID": "IPR024652", "InterPro-Name": "Trichodiene_synth", "InterPro-Type": "FAMILY", "Beg": 5, "End": 377 }, { "InterPro-ID": "IPR008949", "InterPro-Name": "Isoprenoid_synthase_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 3, "End": 352 }, { "InterPro-ID": "IPR010458", "InterPro-Name": "TRI5_ascomyc", "InterPro-Type": "FAMILY", "Beg": 1, "End": 368 } ], "response#1": "MDMNTFPASTYCESIVRFLDAIEYHDDNLTHEERVEGLRHVHSKTAQYFTEPLPRSILKGVAPRRIAAVTRTISHFIVYCWSKLPREAQVDVSIYLSIINVLDDEISSEPSTQMTSFWSDLIQGKQPKHPFWVLFNSHLPRLLRHYGSFCAFNIMRCTFDYFEGCWIEQHNFQGYPGADCYPSFLRRLNCLGGAVAGTIFPAAKFDEQKLFAQMSCVMAQIDGPVALMNDLFSFYKEYDQDEANLVSNWCTVDGITMDQALTRLTDDTIHACVRILDILKDKDPDMLATIRGFIHGYATWHICDFRYRLREIYDREDLQESGARFREYFDKAIDVGWVDVEEWTCQVQGFEVEGPAPSGSEVQAYQANAFGFSVDTQRHHNIDYVGSSILGLFEWATRYLRGKLPLGNA", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Trichodiene_synth, Trichodiene_synth, TRI5_ascomyc that shares evolutionary origin and functional similarity; 2. The protein should be classified within Isoprenoid_synthase_dom_sf, Isoprenoid_synthase_dom_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MDMNTFPASTYCESIVRFLDAIEYHDDNLTHEERVEGLRHVHSKTAQYFTEPLPRSILKGVAPRRIAAVTRTISHFIVYCWSKLPREAQVDVSIYLSIINVLDDEISSEPSTQMTSFWSDLIQGKQPKHPFWVLFNSHLPRLLRHYGSFCAFNIMRCTFDYFEGCWIEQHNFQGYPGADCYPSFLRRLNCLGGAVAGTIFPAAKFDEQKLFAQMSCVMAQIDGPVALMNDLFSFYKEYDQDEANLVSNWCTVDGITMDQALTRLTDDTIHACVRILDILKDKDPDMLATIRGFIHGYATWHICDFRYRLREIYDREDLQESGARFREYFDKAIDVGWVDVEEWTCQVQGFEVEGPAPSGSEVQAYQANAFGFSVDTQRHHNIDYVGSSILGLFEWATRYLRGKLPLGNA" }, { "InterPro": [ { "InterPro-ID": "IPR036396", "InterPro-Name": "Cyt_P450_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 30, "End": 499 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 364, "End": 382 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 442, "End": 452 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 300, "End": 317 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 320, "End": 346 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 406, "End": 430 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 452, "End": 475 }, { "InterPro-ID": "IPR050121", "InterPro-Name": "Cytochrome_P450_monoxygenase", "InterPro-Type": "FAMILY", "Beg": 11, "End": 476 }, { "InterPro-ID": "IPR036396", "InterPro-Name": "Cyt_P450_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 29, "End": 489 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 311, "End": 328 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 452, "End": 463 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 443, "End": 452 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 365, "End": 376 }, { "InterPro-ID": "IPR017972", "InterPro-Name": "Cyt_P450_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 445, "End": 454 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 64, "End": 495 } ], "response#1": "MLFQDLSFPAAIGAVFGAVAISVAARCIYDLFFHPLRNFPGPKRAAIWSFYEFYYDVIRDGTYLWEIEKMHQKYGPIVRINSRSLHIHDPEYFNTIYAGSGRKVNKELSAVSGYTFPHSTISTLDHDLHRKRRAIVSPYFSKRAIAEIEPVIHERLNVLISRLAEAKGSIVDLTSAFSAYTADVVTYHFYGTHANYIGSKDFKYGLKDALTVLLNLYNLTRFLPVPANTLKNLPLPILGLINPNFPLVVSAREANKKMVLGYLNKPDEDKKAMKDARSKSVIVSALTDPNVPDAEKTLDRLLDEGETIIFAGIDTTARTLGVALFHLLNNKDVLMKLRKELQAVAKPDGQQWTTTELEAVPYMRGVVQEAIRLAYGLVVRIPRISPHEALRYNGFVIPPGTPVSQSTYLVNNDPSVFPNPQVFDPERWVKAAQDGVSLDKYMVSFSKGSRGCLGINLAYAKLYLGIARVATSLDMELFETTAKAISVYHTRGFAFPKEGDGAVKARVMGLCK", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Cyt_P450_E_grp-I, Cyt_P450_E_grp-I, Cyt_P450_E_grp-I, Cyt_P450_E_grp-I, Cyt_P450_E_grp-I, Cyt_P450_E_grp-I, Cytochrome_P450_monoxygenase, Cyt_P450, Cyt_P450, Cyt_P450, Cyt_P450, Cyt_P450 that shares evolutionary origin and functional similarity; 2. The protein should be classified within Cyt_P450_sf, Cyt_P450_sf sharing conserved structural features; 3. The protein should contain Cyt_P450_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MLFQDLSFPAAIGAVFGAVAISVAARCIYDLFFHPLRNFPGPKRAAIWSFYEFYYDVIRDGTYLWEIEKMHQKYGPIVRINSRSLHIHDPEYFNTIYAGSGRKVNKELSAVSGYTFPHSTISTLDHDLHRKRRAIVSPYFSKRAIAEIEPVIHERLNVLISRLAEAKGSIVDLTSAFSAYTADVVTYHFYGTHANYIGSKDFKYGLKDALTVLLNLYNLTRFLPVPANTLKNLPLPILGLINPNFPLVVSAREANKKMVLGYLNKPDEDKKAMKDARSKSVIVSALTDPNVPDAEKTLDRLLDEGETIIFAGIDTTARTLGVALFHLLNNKDVLMKLRKELQAVAKPDGQQWTTTELEAVPYMRGVVQEAIRLAYGLVVRIPRISPHEALRYNGFVIPPGTPVSQSTYLVNNDPSVFPNPQVFDPERWVKAAQDGVSLDKYMVSFSKGSRGCLGINLAYAKLYLGIARVATSLDMELFETTAKAISVYHTRGFAFPKEGDGAVKARVMGLCK" }, { "InterPro": [ { "InterPro-ID": "IPR017972", "InterPro-Name": "Cyt_P450_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 474, "End": 483 }, { "InterPro-ID": "IPR036396", "InterPro-Name": "Cyt_P450_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 63, "End": 538 }, { "InterPro-ID": "IPR036396", "InterPro-Name": "Cyt_P450_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 66, "End": 537 }, { "InterPro-ID": "IPR002403", "InterPro-Name": "Cyt_P450_E_grp-IV", "InterPro-Type": "FAMILY", "Beg": 373, "End": 389 }, { "InterPro-ID": "IPR002403", "InterPro-Name": "Cyt_P450_E_grp-IV", "InterPro-Type": "FAMILY", "Beg": 465, "End": 481 }, { "InterPro-ID": "IPR002403", "InterPro-Name": "Cyt_P450_E_grp-IV", "InterPro-Type": "FAMILY", "Beg": 481, "End": 499 }, { "InterPro-ID": "IPR002403", "InterPro-Name": "Cyt_P450_E_grp-IV", "InterPro-Type": "FAMILY", "Beg": 425, "End": 443 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 153, "End": 531 } ], "response#1": "MGASTFSQSFAEGYAAWALMLPALVGCALLIYRAFFAIRYPANLPLAGEPDGKRTFSWRTRWRYYIDCEALYKETYDNYTKHGKTVLLPGLGFRHDIVLPQSAMRDIMARPEKELSHADAVLELVQLKYSLGHEKYKADPWPCMLVKSDINSKLEAVCDGMNEELKYAFDKYVGCDTESWKEVDLLETIRMIIMAAASRFTVGFPLCRSEAYLRACWKVNDGIMMNGGLTGATPRLLRPIVGPLVTMKLRQSIEQVKKHVEPIYRQRVQALSQQNSAEKPASDETQDLFQQMLRYAQRERPGELHDLPSMCRRLCFANFAAVHQTTLLVTNMVLNIVSSDPQHNTISVLRDEVKDVIGPDSNAKWTKYKVAQMIKSDSVARETMRLYSNTNRGVFRKVLVEGIKTEDGIELPKGAYVSFLGRPLQCDPETFEDPFEYNPFRFSRIREQAPRDTKGRSSASHLSFVSTSPEHLPFGHGGHSCPGRFLVDFEVKMIVAYLLMNYDVEFPAEYKGQRPANRWMAEALMPPSGARIRIKRRS", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Cyt_P450_E_grp-IV, Cyt_P450_E_grp-IV, Cyt_P450_E_grp-IV, Cyt_P450_E_grp-IV, Cyt_P450 that shares evolutionary origin and functional similarity; 2. The protein should be classified within Cyt_P450_sf, Cyt_P450_sf sharing conserved structural features; 3. The protein should contain Cyt_P450_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MGASTFSQSFAEGYAAWALMLPALVGCALLIYRAFFAIRYPANLPLAGEPDGKRTFSWRTRWRYYIDCEALYKETYDNYTKHGKTVLLPGLGFRHDIVLPQSAMRDIMARPEKELSHADAVLELVQLKYSLGHEKYKADPWPCMLVKSDINSKLEAVCDGMNEELKYAFDKYVGCDTESWKEVDLLETIRMIIMAAASRFTVGFPLCRSEAYLRACWKVNDGIMMNGGLTGATPRLLRPIVGPLVTMKLRQSIEQVKKHVEPIYRQRVQALSQQNSAEKPASDETQDLFQQMLRYAQRERPGELHDLPSMCRRLCFANFAAVHQTTLLVTNMVLNIVSSDPQHNTISVLRDEVKDVIGPDSNAKWTKYKVAQMIKSDSVARETMRLYSNTNRGVFRKVLVEGIKTEDGIELPKGAYVSFLGRPLQCDPETFEDPFEYNPFRFSRIREQAPRDTKGRSSASHLSFVSTSPEHLPFGHGGHSCPGRFLVDFEVKMIVAYLLMNYDVEFPAEYKGQRPANRWMAEALMPPSGARIRIKRRS" }, { "InterPro": [ { "InterPro-ID": "IPR039261", "InterPro-Name": "FNR_nucleotide-bd", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 123, "End": 263 }, { "InterPro-ID": "IPR007037", "InterPro-Name": "SIP_C", "InterPro-Type": "DOMAIN", "Beg": 129, "End": 248 }, { "InterPro-ID": "IPR013113", "InterPro-Name": "FAD-bd_9_SIP", "InterPro-Type": "DOMAIN", "Beg": 17, "End": 119 }, { "InterPro-ID": "IPR017938", "InterPro-Name": "Riboflavin_synthase-like_b-brl", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 16, "End": 119 }, { "InterPro-ID": "IPR039374", "InterPro-Name": "SIP_fam", "InterPro-Type": "FAMILY", "Beg": 14, "End": 250 }, { "InterPro-ID": "IPR017927", "InterPro-Name": "FAD-bd_FR_type", "InterPro-Type": "DOMAIN", "Beg": 9, "End": 127 } ], "response#1": "MNNQSAKKSPTRLTYISDIIEISPYLRRLVLSGEQLANFPADQQGAYVKVLIPQPGETTVNMTLTGPNAAIKRSYTIREFDPVRGQLSLDFVINKHTGPATDWAKLANVGDTVAIAGPGPLKMNRFDFNDYLLFGDSTSINAVDALIKRLPATAKGHIIMLVNSHQEQALLSQHPLLKTHWLVLNDSITAEQQIDWLLDKLELFGDLPAVTQVFVGLEATQVRVIKQYLLEQQQLPLSSISATGYWKRNTDADTFGKQKQMQPL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more SIP_C, FAD-bd_9_SIP, FAD-bd_FR_type that are essential for its biological function; 2. The protein should belong to SIP_fam that shares evolutionary origin and functional similarity; 3. The protein should be classified within FNR_nucleotide-bd, Riboflavin_synthase-like_b-brl sharing conserved structural features. The designed protein sequence is ", "reference": "MNNQSAKKSPTRLTYISDIIEISPYLRRLVLSGEQLANFPADQQGAYVKVLIPQPGETTVNMTLTGPNAAIKRSYTIREFDPVRGQLSLDFVINKHTGPATDWAKLANVGDTVAIAGPGPLKMNRFDFNDYLLFGDSTSINAVDALIKRLPATAKGHIIMLVNSHQEQALLSQHPLLKTHWLVLNDSITAEQQIDWLLDKLELFGDLPAVTQVFVGLEATQVRVIKQYLLEQQQLPLSSISATGYWKRNTDADTFGKQKQMQPL" }, { "InterPro": [ { "InterPro-ID": "IPR002347", "InterPro-Name": "SDR_fam", "InterPro-Type": "FAMILY", "Beg": 126, "End": 134 }, { "InterPro-ID": "IPR002347", "InterPro-Name": "SDR_fam", "InterPro-Type": "FAMILY", "Beg": 146, "End": 165 }, { "InterPro-ID": "IPR002347", "InterPro-Name": "SDR_fam", "InterPro-Type": "FAMILY", "Beg": 74, "End": 85 }, { "InterPro-ID": "IPR002347", "InterPro-Name": "SDR_fam", "InterPro-Type": "FAMILY", "Beg": 5, "End": 22 }, { "InterPro-ID": "IPR002347", "InterPro-Name": "SDR_fam", "InterPro-Type": "FAMILY", "Beg": 120, "End": 136 }, { "InterPro-ID": "IPR002347", "InterPro-Name": "SDR_fam", "InterPro-Type": "FAMILY", "Beg": 167, "End": 184 }, { "InterPro-ID": "IPR036291", "InterPro-Name": "NAD(P)-bd_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 4, "End": 194 }, { "InterPro-ID": "IPR002347", "InterPro-Name": "SDR_fam", "InterPro-Type": "FAMILY", "Beg": 4, "End": 186 } ], "response#1": "MTRKSILVTGASSGLGYAAVQKLAENGFYVFAAVREIRGMFSNIKNIKELKLDLANEQSIEELFIYIEATQKDYPLWGLVNNAGICVPSPLELLREFDLRQQLDTNVIGQLLVTQFALPFIRKSKGRIINITSGLGSIAVPYLGAYSIAQFAKMAFTDVLRRELKHSGVTVSVVQPGAIYTPIWDKFLVTGQEILDNSLDEKRKIYERSFIEFLKASQIGVNSVKTTRNDFAKVILDIFKAEIPETHYYVGDDAKNFSNKSKILTVTEIDEWFDLQSPTESEFKKI", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to SDR_fam, SDR_fam, SDR_fam, SDR_fam, SDR_fam, SDR_fam, SDR_fam that shares evolutionary origin and functional similarity; 2. The protein should be classified within NAD(P)-bd_dom_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MTRKSILVTGASSGLGYAAVQKLAENGFYVFAAVREIRGMFSNIKNIKELKLDLANEQSIEELFIYIEATQKDYPLWGLVNNAGICVPSPLELLREFDLRQQLDTNVIGQLLVTQFALPFIRKSKGRIINITSGLGSIAVPYLGAYSIAQFAKMAFTDVLRRELKHSGVTVSVVQPGAIYTPIWDKFLVTGQEILDNSLDEKRKIYERSFIEFLKASQIGVNSVKTTRNDFAKVILDIFKAEIPETHYYVGDDAKNFSNKSKILTVTEIDEWFDLQSPTESEFKKI" }, { "InterPro": [ { "InterPro-ID": "IPR023355", "InterPro-Name": "Myo_ane_neurotoxin_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 45, "End": 89 } ], "response#1": "MKTQVLVVLVLCVVFCLAESRNSMTSEERGLVSLMRQRDDIAKRLQCKCKGDAPDLSHMSGTIYFSCEGGDNSWKKCNSISVFADCCHKKPT", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should be classified within Myo_ane_neurotoxin_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MKTQVLVVLVLCVVFCLAESRNSMTSEERGLVSLMRQRDDIAKRLQCKCKGDAPDLSHMSGTIYFSCEGGDNSWKKCNSISVFADCCHKKPT" }, { "InterPro": [ { "InterPro-ID": "IPR040624", "InterPro-Name": "HalOD1", "InterPro-Type": "DOMAIN", "Beg": 9, "End": 62 } ], "response#1": "MDKHARGDADLPPLTDHVDTDALDTLFGRDTPGAPRVSGASLEFDYADFVVTVESVGRIEVRDAGR", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more HalOD1 that are essential for its biological function. The designed protein sequence is ", "reference": "MDKHARGDADLPPLTDHVDTDALDTLFGRDTPGAPRVSGASLEFDYADFVVTVESVGRIEVRDAGR" }, { "InterPro": [ { "InterPro-ID": "IPR036736", "InterPro-Name": "ACP-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1640, "End": 1739 }, { "InterPro-ID": "IPR016039", "InterPro-Name": "Thiolase-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 351, "End": 799 }, { "InterPro-ID": "IPR049551", "InterPro-Name": "PKS_DH_C", "InterPro-Type": "DOMAIN", "Beg": 1410, "End": 1556 }, { "InterPro-ID": "IPR014043", "InterPro-Name": "Acyl_transferase_dom", "InterPro-Type": "DOMAIN", "Beg": 882, "End": 1187 }, { "InterPro-ID": "IPR020841", "InterPro-Name": "PKS_Beta-ketoAc_synthase_dom", "InterPro-Type": "DOMAIN", "Beg": 363, "End": 780 }, { "InterPro-ID": "IPR029063", "InterPro-Name": "SAM-dependent_MTases_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1889, "End": 2127 }, { "InterPro-ID": "IPR006162", "InterPro-Name": "Ppantetheine_attach_site", "InterPro-Type": "PTM", "Beg": 1672, "End": 1687 }, { "InterPro-ID": "IPR032088", "InterPro-Name": "SAT", "InterPro-Type": "DOMAIN", "Beg": 101, "End": 254 }, { "InterPro-ID": "IPR016035", "InterPro-Name": "Acyl_Trfase/lysoPLipase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 879, "End": 1167 }, { "InterPro-ID": "IPR036736", "InterPro-Name": "ACP-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1643, "End": 1719 }, { "InterPro-ID": "IPR009081", "InterPro-Name": "PP-bd_ACP", "InterPro-Type": "DOMAIN", "Beg": 1640, "End": 1717 }, { "InterPro-ID": "IPR049492", "InterPro-Name": "BD-FAE-like_dom", "InterPro-Type": "DOMAIN", "Beg": 2169, "End": 2291 }, { "InterPro-ID": "IPR016039", "InterPro-Name": "Thiolase-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 361, "End": 776 }, { "InterPro-ID": "IPR020841", "InterPro-Name": "PKS_Beta-ketoAc_synthase_dom", "InterPro-Type": "DOMAIN", "Beg": 360, "End": 777 }, { "InterPro-ID": "IPR014031", "InterPro-Name": "Ketoacyl_synth_C", "InterPro-Type": "DOMAIN", "Beg": 612, "End": 728 }, { "InterPro-ID": "IPR001227", "InterPro-Name": "Ac_transferase_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 7, "End": 200 }, { "InterPro-ID": "IPR014043", "InterPro-Name": "Acyl_transferase_dom", "InterPro-Type": "DOMAIN", "Beg": 889, "End": 1137 }, { "InterPro-ID": "IPR049900", "InterPro-Name": "PKS_mFAS_DH", "InterPro-Type": "DOMAIN", "Beg": 1243, "End": 1561 }, { "InterPro-ID": "IPR001227", "InterPro-Name": "Ac_transferase_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 880, "End": 1182 }, { "InterPro-ID": "IPR049552", "InterPro-Name": "PKS_DH_N", "InterPro-Type": "DOMAIN", "Beg": 1280, "End": 1355 }, { "InterPro-ID": "IPR009081", "InterPro-Name": "PP-bd_ACP", "InterPro-Type": "DOMAIN", "Beg": 1647, "End": 1713 }, { "InterPro-ID": "IPR029063", "InterPro-Name": "SAM-dependent_MTases_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1947, "End": 2119 }, { "InterPro-ID": "IPR013217", "InterPro-Name": "Methyltransf_12", "InterPro-Type": "DOMAIN", "Beg": 1960, "End": 2062 }, { "InterPro-ID": "IPR001375", "InterPro-Name": "Peptidase_S9_cat", "InterPro-Type": "DOMAIN", "Beg": 2395, "End": 2489 }, { "InterPro-ID": "IPR050091", "InterPro-Name": "PKS_NRPS_Biosynth_Enz", "InterPro-Type": "FAMILY", "Beg": 307, "End": 1563 }, { "InterPro-ID": "IPR016036", "InterPro-Name": "Malonyl_transacylase_ACP-bd", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1005, "End": 1064 }, { "InterPro-ID": "IPR018201", "InterPro-Name": "Ketoacyl_synth_AS", "InterPro-Type": "ACTIVE_SITE", "Beg": 517, "End": 533 }, { "InterPro-ID": "IPR029058", "InterPro-Name": "AB_hydrolase_fold", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 2067, "End": 2488 }, { "InterPro-ID": "IPR029058", "InterPro-Name": "AB_hydrolase_fold", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 2154, "End": 2486 }, { "InterPro-ID": "IPR042104", "InterPro-Name": "PKS_dehydratase_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1268, "End": 1560 }, { "InterPro-ID": "IPR014030", "InterPro-Name": "Ketoacyl_synth_N", "InterPro-Type": "DOMAIN", "Beg": 361, "End": 604 } ], "response#1": "MTQFGTSPISRTQEFVVALFGPQVTHWTQDSLSNLQSDLLGNPNLEFVAKSLLELPSLWSELEQEYDFEGSRGAHTLKELHDFATGEKSLDPQTLTNTHLAPLTVVYQVIDFIRSAGNPGTKESLRGFEAAQGFCIGFLSAAALASANDWSDFERNVSNAIRLATCIGIIVDAEEASHPAQDRATAISVHWKTAADRTYLETCLDNVPEAYISCITDDRNLTVTLPKDHEEAFCARLREDKISTTSVGLNGCYHHSRHVEAANKLAKLCTANSDLRLPSAGSLRLPLRSTADGSIIKNGALHEIAIQLILCKRAHWFQTVKSTLGDLTPDKATFVPLGTKSCIPRSLSAIRYNHDDENALEEIAVVGMACRFPQADTLEEFWEIIQAGKTALSTMPLERFNPADITREPKLPEYWGNFLRRPDAFDHRFFGISGREAKSMDPQQRLALQVAYEALESSGYCVNETSSRVTDVGCYLGVGSVDYEDNIESENANAFAATGMLRAFISGRISHFYGWTGPSITFDTACSSSAVAIHTACKALLGGECSMALAGGVNVITSPTLHQNLAGASFLNPNGSSRAFDTMAGGYCRGEGAGILVLKPLSRAVADGDTVLGVIAASAVNQGSNCSPITVPDSWSQSSLYERVLTTARIKPTEVTYVEAHGTGTPVGDPIEYESVRMALTGPSRNSELFLGSVKDSIGHTEAASGVAAVIKTLLMMQHKTIPKQANFVSLNPRIKASSSNKIVVPKTTQPWTSQKHVALVNNYGAAGSNAAILVRAHSEVPLDSTSGVKTQDTSAVYPILLSAKSPSNLQSYVDALKLYLPQAKASLGGIAYNIARTHNSTFDNRIAFTASDIQSLSSGLNNFTISGGIITRTDKFPVVLCFGGQTGRKVTVSKDLYDNCDIFRKHLDECNAVCHQLGLPSIFPEIFQGKDIEDIVTLHCMLLSLQISSAKSWIDSGLEVDTVIGHSFGQLTALCIAGSISLEDTFRLISGRARIIRDSWNTESGAMLSVECDKEEIEAVAKRLNTTSDYRVDIACYNGPRSFVLAGDARSVDKAEEECSSFKKTRLQNTHAYHSYVADGILSDLKGLAESITLRPPRIRVETCSAGDNWSSFTADEVVKHTRQPVYFADAVERIATRLSSAIWLEAGSASPIVAMARRIIPKTDRSDVFIPIELGSDGATANLANAACQLWKAGSATQHWAFHKSSSSRYTRINLPPYQFDKTSHWIEYKPRTKVGVSENQNIVSKVSSLVSILRSKVKGENLFSVDTSNVIFQLAGQGHAVTGQSLCPASMYVELVVRCATLLLDAAYTAKAVPHVEGLTMSAPLGLGAGISVFIRLSNVAQGKWDFAIFSRSSINGDAESSETEHAKGIISCVPADDAVAEGRLKLLRRLARTSRIDRIKKLPSATGVSGAMVYKLFSDVVEYASYYRGVRNLSAVDNEAVGLVTVPTEQPLGMDAGICDPISLDNFLQVAGIHVNCLSPRKQDEVFMCTAVEEVIFSASFMANRGHSRSWIVYTRYETTSNSIIANDIFVCDAASKELVVAIMGATFRSVPFRSLSRSLSRLNGMPNTNIIAAVERSPQISDSDSDDADSEYQKGYTPLTEYEDEKPLTKHGYFSHTQSPLASLGIQQQPAEEPTESPDIVQKVRDMFSAIIEIPVEEIEPSSSLDDLGIDSLLVTEVLVEIQSRFGVKITQAQFQECTDVLDVARFIQPVEKTNKSQPPVEKTGVKHSFTEKPLNGASDPANRHGIDNINQIRENLAIVSRDSFIEAKPSYDQHAETTGFKNFNTEVFPLQSELVVQYVLAAFASLGCVVPDLKFGDEAPIIRFDPKHNKVVPQLYKILEDAGLLKKGEDGVLRRTEVPIQMVPTLPLHEKMLKLFPKHASETKLLYTTGHRLADCLSGAADPIALLFGDSDARALLADVYTNAPMFKTGTLLLSQYLTSVLKGFKGGRELKILELGAGTGGTTKDVVEKLAALGPEYKFSYTFTDLSSSLVAAARRKFAKWSFMRYTVVDIEKDPNPQFLGAYDIIISTNCIHATKNLVNSTTNIRKMLGPDGVLCLVELTRNLFWFDLVFGLLEGWWLFSDGRKHALASEGLWKRDLNAAGFNWVDWSDTSSSESDILRVITASPYAIGNKTADSLPIGDGLPLKETVTFKEVDGLELQADIYYPPKVVDSGRTLPVALMIHGGGHVMLSRNDIRPKQTNMLIKSGFLPISIDYRLCPEVTLPEGPMSDAADALLWIRTVLPKLTLSRHDVRVNAERVVAVGWSSGGHLAMSLAWTSQARQIQPPSAILAFYSPSDYEDSFWSEPNIPAGSRVMNGATSYELDDQVWAGISDHAIVGYNPPPTKRALGGWLAPTDPRSRLALYMNWHGRTLHTILGGLDKNDRKEPGTPAPELVKVISPLAQARAGNYATPTFLIHPREDDLVPWQQAERTWQALQATGTQAELRIVEDVPHLFDLYPEHQSNEVLTRVVAEGYEFLCQHVGLSD", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more PKS_DH_C, Acyl_transferase_dom, PKS_Beta-ketoAc_synthase_dom, SAT, PP-bd_ACP, BD-FAE-like_dom, PKS_Beta-ketoAc_synthase_dom, Ketoacyl_synth_C, Acyl_transferase_dom, PKS_mFAS_DH, PKS_DH_N, PP-bd_ACP, Methyltransf_12, Peptidase_S9_cat, Ketoacyl_synth_N that are essential for its biological function; 2. The protein should belong to PKS_NRPS_Biosynth_Enz that shares evolutionary origin and functional similarity; 3. The protein should be classified within ACP-like_sf, Thiolase-like, SAM-dependent_MTases_sf, Acyl_Trfase/lysoPLipase, ACP-like_sf, Thiolase-like, Ac_transferase_dom_sf, Ac_transferase_dom_sf, SAM-dependent_MTases_sf, Malonyl_transacylase_ACP-bd, AB_hydrolase_fold, AB_hydrolase_fold, PKS_dehydratase_sf sharing conserved structural features; 4. The protein must have Ketoacyl_synth_AS that is conserved among related catalytic enzymes; 5. The protein should contain Ppantetheine_attach_site that allow regulation through chemical modifications. The designed protein sequence is ", "reference": "MTQFGTSPISRTQEFVVALFGPQVTHWTQDSLSNLQSDLLGNPNLEFVAKSLLELPSLWSELEQEYDFEGSRGAHTLKELHDFATGEKSLDPQTLTNTHLAPLTVVYQVIDFIRSAGNPGTKESLRGFEAAQGFCIGFLSAAALASANDWSDFERNVSNAIRLATCIGIIVDAEEASHPAQDRATAISVHWKTAADRTYLETCLDNVPEAYISCITDDRNLTVTLPKDHEEAFCARLREDKISTTSVGLNGCYHHSRHVEAANKLAKLCTANSDLRLPSAGSLRLPLRSTADGSIIKNGALHEIAIQLILCKRAHWFQTVKSTLGDLTPDKATFVPLGTKSCIPRSLSAIRYNHDDENALEEIAVVGMACRFPQADTLEEFWEIIQAGKTALSTMPLERFNPADITREPKLPEYWGNFLRRPDAFDHRFFGISGREAKSMDPQQRLALQVAYEALESSGYCVNETSSRVTDVGCYLGVGSVDYEDNIESENANAFAATGMLRAFISGRISHFYGWTGPSITFDTACSSSAVAIHTACKALLGGECSMALAGGVNVITSPTLHQNLAGASFLNPNGSSRAFDTMAGGYCRGEGAGILVLKPLSRAVADGDTVLGVIAASAVNQGSNCSPITVPDSWSQSSLYERVLTTARIKPTEVTYVEAHGTGTPVGDPIEYESVRMALTGPSRNSELFLGSVKDSIGHTEAASGVAAVIKTLLMMQHKTIPKQANFVSLNPRIKASSSNKIVVPKTTQPWTSQKHVALVNNYGAAGSNAAILVRAHSEVPLDSTSGVKTQDTSAVYPILLSAKSPSNLQSYVDALKLYLPQAKASLGGIAYNIARTHNSTFDNRIAFTASDIQSLSSGLNNFTISGGIITRTDKFPVVLCFGGQTGRKVTVSKDLYDNCDIFRKHLDECNAVCHQLGLPSIFPEIFQGKDIEDIVTLHCMLLSLQISSAKSWIDSGLEVDTVIGHSFGQLTALCIAGSISLEDTFRLISGRARIIRDSWNTESGAMLSVECDKEEIEAVAKRLNTTSDYRVDIACYNGPRSFVLAGDARSVDKAEEECSSFKKTRLQNTHAYHSYVADGILSDLKGLAESITLRPPRIRVETCSAGDNWSSFTADEVVKHTRQPVYFADAVERIATRLSSAIWLEAGSASPIVAMARRIIPKTDRSDVFIPIELGSDGATANLANAACQLWKAGSATQHWAFHKSSSSRYTRINLPPYQFDKTSHWIEYKPRTKVGVSENQNIVSKVSSLVSILRSKVKGENLFSVDTSNVIFQLAGQGHAVTGQSLCPASMYVELVVRCATLLLDAAYTAKAVPHVEGLTMSAPLGLGAGISVFIRLSNVAQGKWDFAIFSRSSINGDAESSETEHAKGIISCVPADDAVAEGRLKLLRRLARTSRIDRIKKLPSATGVSGAMVYKLFSDVVEYASYYRGVRNLSAVDNEAVGLVTVPTEQPLGMDAGICDPISLDNFLQVAGIHVNCLSPRKQDEVFMCTAVEEVIFSASFMANRGHSRSWIVYTRYETTSNSIIANDIFVCDAASKELVVAIMGATFRSVPFRSLSRSLSRLNGMPNTNIIAAVERSPQISDSDSDDADSEYQKGYTPLTEYEDEKPLTKHGYFSHTQSPLASLGIQQQPAEEPTESPDIVQKVRDMFSAIIEIPVEEIEPSSSLDDLGIDSLLVTEVLVEIQSRFGVKITQAQFQECTDVLDVARFIQPVEKTNKSQPPVEKTGVKHSFTEKPLNGASDPANRHGIDNINQIRENLAIVSRDSFIEAKPSYDQHAETTGFKNFNTEVFPLQSELVVQYVLAAFASLGCVVPDLKFGDEAPIIRFDPKHNKVVPQLYKILEDAGLLKKGEDGVLRRTEVPIQMVPTLPLHEKMLKLFPKHASETKLLYTTGHRLADCLSGAADPIALLFGDSDARALLADVYTNAPMFKTGTLLLSQYLTSVLKGFKGGRELKILELGAGTGGTTKDVVEKLAALGPEYKFSYTFTDLSSSLVAAARRKFAKWSFMRYTVVDIEKDPNPQFLGAYDIIISTNCIHATKNLVNSTTNIRKMLGPDGVLCLVELTRNLFWFDLVFGLLEGWWLFSDGRKHALASEGLWKRDLNAAGFNWVDWSDTSSSESDILRVITASPYAIGNKTADSLPIGDGLPLKETVTFKEVDGLELQADIYYPPKVVDSGRTLPVALMIHGGGHVMLSRNDIRPKQTNMLIKSGFLPISIDYRLCPEVTLPEGPMSDAADALLWIRTVLPKLTLSRHDVRVNAERVVAVGWSSGGHLAMSLAWTSQARQIQPPSAILAFYSPSDYEDSFWSEPNIPAGSRVMNGATSYELDDQVWAGISDHAIVGYNPPPTKRALGGWLAPTDPRSRLALYMNWHGRTLHTILGGLDKNDRKEPGTPAPELVKVISPLAQARAGNYATPTFLIHPREDDLVPWQQAERTWQALQATGTQAELRIVEDVPHLFDLYPEHQSNEVLTRVVAEGYEFLCQHVGLSD" }, { "InterPro": [ { "InterPro-ID": "IPR016090", "InterPro-Name": "PLipase_A2_dom", "InterPro-Type": "DOMAIN", "Beg": 38, "End": 146 }, { "InterPro-ID": "IPR036444", "InterPro-Name": "PLipase_A2_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 36, "End": 157 }, { "InterPro-ID": "IPR001211", "InterPro-Name": "PLipase_A2", "InterPro-Type": "FAMILY", "Beg": 9, "End": 156 }, { "InterPro-ID": "IPR033113", "InterPro-Name": "PLipase_A2_His_AS", "InterPro-Type": "ACTIVE_SITE", "Beg": 77, "End": 84 }, { "InterPro-ID": "IPR036444", "InterPro-Name": "PLipase_A2_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 29, "End": 157 }, { "InterPro-ID": "IPR001211", "InterPro-Name": "PLipase_A2", "InterPro-Type": "FAMILY", "Beg": 51, "End": 69 }, { "InterPro-ID": "IPR001211", "InterPro-Name": "PLipase_A2", "InterPro-Type": "FAMILY", "Beg": 70, "End": 88 }, { "InterPro-ID": "IPR001211", "InterPro-Name": "PLipase_A2", "InterPro-Type": "FAMILY", "Beg": 120, "End": 136 }, { "InterPro-ID": "IPR016090", "InterPro-Name": "PLipase_A2_dom", "InterPro-Type": "DOMAIN", "Beg": 36, "End": 156 } ], "response#1": "MKVLQMFFCVILLCVTSVLVEAKSTTKGDETASKRNFAQFAAMTYHTTHRWPKKYVGYGCYCGLGGYGIPVDPIDECCKTHDACYKKVEDSGICSYSWAIYLTIYKRKGGAECSEDNEKCQMEVCKCDSVAAKCLGKYKDIFNEKYAGYDKKGKCDPSFTLS", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more PLipase_A2_dom, PLipase_A2_dom that are essential for its biological function; 2. The protein should belong to PLipase_A2, PLipase_A2, PLipase_A2, PLipase_A2 that shares evolutionary origin and functional similarity; 3. The protein should be classified within PLipase_A2_dom_sf, PLipase_A2_dom_sf sharing conserved structural features; 4. The protein must have PLipase_A2_His_AS that is conserved among related catalytic enzymes. The designed protein sequence is ", "reference": "MKVLQMFFCVILLCVTSVLVEAKSTTKGDETASKRNFAQFAAMTYHTTHRWPKKYVGYGCYCGLGGYGIPVDPIDECCKTHDACYKKVEDSGICSYSWAIYLTIYKRKGGAECSEDNEKCQMEVCKCDSVAAKCLGKYKDIFNEKYAGYDKKGKCDPSFTLS" }, { "InterPro": [ { "InterPro-ID": "IPR012132", "InterPro-Name": "GMC_OxRdtase", "InterPro-Type": "FAMILY", "Beg": 30, "End": 603 }, { "InterPro-ID": "IPR007867", "InterPro-Name": "GMC_OxRtase_C", "InterPro-Type": "DOMAIN", "Beg": 455, "End": 592 }, { "InterPro-ID": "IPR036188", "InterPro-Name": "FAD/NAD-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 31, "End": 601 }, { "InterPro-ID": "IPR012132", "InterPro-Name": "GMC_OxRdtase", "InterPro-Type": "FAMILY", "Beg": 10, "End": 603 }, { "InterPro-ID": "IPR036188", "InterPro-Name": "FAD/NAD-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 35, "End": 600 }, { "InterPro-ID": "IPR000172", "InterPro-Name": "GMC_OxRdtase_N", "InterPro-Type": "DOMAIN", "Beg": 35, "End": 345 } ], "response#1": "MYMLRPSSLLLATGLLNQGSSVLAAVISRASNQTFDYVIVGGGTAGLVLANRLTEDSSVTVAVVEAGTFPEDVVGNVTQVPAYAPQFEGAELDLEWNFTTTPQAGLGNIPVSYYRAKALGGCSDINFMAYGRTSKGAHQLWADLVGDDSYTYDNMVKYYKKTMNFSPPNAETRLANATPMYDTVDTSTGGGIDVTFPSFAQSWSTWVSKGLAAIGLPQAHSFVDGNLLGHSWQMVGITQSTGIRSSAQAGYLRPVMSRPNLTILNGTFAERIIFNGDAASGVEVTAKGQTYTLTSKKELILSAGVFQSPQLLMVSGVGPKALLDKFNIPVVKDLPGVGQNMVDHITVPLSYQVDVVTSSTLAGSSLEEAITEWNTHGTGPLSNNGGDYIGMEKAPAEFRANFSAETVKQLSALPEDWPELQYNVLPATVSSTSIGGEGSVLGGNYGSMLASVIAPQSRGNVSIASASMSDAPLINPNIFTAQADIDLLLTAFKRVRQALQSSAMAPIMIGDEFFPGPTVQTDEQILDYLTETVRPFSHGFATCKMGKSSDPDAVIDSHGKVYGIKNLRVVDASSFPFLPPGPAPQIQVYTLAEKLADDIKQTKY", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more GMC_OxRtase_C, GMC_OxRdtase_N that are essential for its biological function; 2. The protein should belong to GMC_OxRdtase, GMC_OxRdtase that shares evolutionary origin and functional similarity; 3. The protein should be classified within FAD/NAD-bd_sf, FAD/NAD-bd_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MYMLRPSSLLLATGLLNQGSSVLAAVISRASNQTFDYVIVGGGTAGLVLANRLTEDSSVTVAVVEAGTFPEDVVGNVTQVPAYAPQFEGAELDLEWNFTTTPQAGLGNIPVSYYRAKALGGCSDINFMAYGRTSKGAHQLWADLVGDDSYTYDNMVKYYKKTMNFSPPNAETRLANATPMYDTVDTSTGGGIDVTFPSFAQSWSTWVSKGLAAIGLPQAHSFVDGNLLGHSWQMVGITQSTGIRSSAQAGYLRPVMSRPNLTILNGTFAERIIFNGDAASGVEVTAKGQTYTLTSKKELILSAGVFQSPQLLMVSGVGPKALLDKFNIPVVKDLPGVGQNMVDHITVPLSYQVDVVTSSTLAGSSLEEAITEWNTHGTGPLSNNGGDYIGMEKAPAEFRANFSAETVKQLSALPEDWPELQYNVLPATVSSTSIGGEGSVLGGNYGSMLASVIAPQSRGNVSIASASMSDAPLINPNIFTAQADIDLLLTAFKRVRQALQSSAMAPIMIGDEFFPGPTVQTDEQILDYLTETVRPFSHGFATCKMGKSSDPDAVIDSHGKVYGIKNLRVVDASSFPFLPPGPAPQIQVYTLAEKLADDIKQTKY" }, { "InterPro": [ { "InterPro-ID": "IPR022352", "InterPro-Name": "Insulin_family", "InterPro-Type": "FAMILY", "Beg": 95, "End": 114 }, { "InterPro-ID": "IPR022352", "InterPro-Name": "Insulin_family", "InterPro-Type": "FAMILY", "Beg": 38, "End": 54 }, { "InterPro-ID": "IPR016724", "InterPro-Name": "Insulin-rel_pep", "InterPro-Type": "FAMILY", "Beg": 1, "End": 71 }, { "InterPro-ID": "IPR016724", "InterPro-Name": "Insulin-rel_pep", "InterPro-Type": "FAMILY", "Beg": 54, "End": 115 }, { "InterPro-ID": "IPR022353", "InterPro-Name": "Insulin_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 100, "End": 114 }, { "InterPro-ID": "IPR036438", "InterPro-Name": "Insulin-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 31, "End": 114 }, { "InterPro-ID": "IPR016179", "InterPro-Name": "Insulin-like", "InterPro-Type": "DOMAIN", "Beg": 39, "End": 114 } ], "response#1": "MFVYTTIMLLLLAEINHSQGCSGLCKINESPQTNIDYRICGDQITQKYTELCGNPAAGRRNRITGLDQRSIFESNLLAKRFLISRRQIVNNRRTDIVEECCAEGCKAEEVKEYCI", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Insulin-like that are essential for its biological function; 2. The protein should belong to Insulin_family, Insulin_family, Insulin-rel_pep, Insulin-rel_pep that shares evolutionary origin and functional similarity; 3. The protein should be classified within Insulin-like_sf sharing conserved structural features; 4. The protein should contain Insulin_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MFVYTTIMLLLLAEINHSQGCSGLCKINESPQTNIDYRICGDQITQKYTELCGNPAAGRRNRITGLDQRSIFESNLLAKRFLISRRQIVNNRRTDIVEECCAEGCKAEEVKEYCI" }, { "InterPro": [ { "InterPro-ID": "IPR029237", "InterPro-Name": "Long_scorpion_toxin_alpha/beta", "InterPro-Type": "DOMAIN", "Beg": 55, "End": 95 }, { "InterPro-ID": "IPR029237", "InterPro-Name": "Long_scorpion_toxin_alpha/beta", "InterPro-Type": "DOMAIN", "Beg": 43, "End": 90 } ], "response#1": "MNCKLTALLFLGLIVIASCGWINEKKMQQKIDEKIGKNIIGGMAKAVIHKMAKNEFQCVANVDTLGNCKKHCAKTTGEKGYCHGTKCKCGIELSY", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Long_scorpion_toxin_alpha/beta, Long_scorpion_toxin_alpha/beta that are essential for its biological function. The designed protein sequence is ", "reference": "MNCKLTALLFLGLIVIASCGWINEKKMQQKIDEKIGKNIIGGMAKAVIHKMAKNEFQCVANVDTLGNCKKHCAKTTGEKGYCHGTKCKCGIELSY" }, { "InterPro": [ { "InterPro-ID": "IPR022353", "InterPro-Name": "Insulin_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 45, "End": 59 }, { "InterPro-ID": "IPR036438", "InterPro-Name": "Insulin-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 36, "End": 59 }, { "InterPro-ID": "IPR016179", "InterPro-Name": "Insulin-like", "InterPro-Type": "DOMAIN", "Beg": 39, "End": 59 } ], "response#1": "MPRTFLVVLIYILAGFLCSTSALRKVNEASGIKTDGSGYTIVEECCTESCKLEEVNEYCHLFRGRFFCGEQILDIYNTVCNPRSIRRKRSLTVDKREAKKFIRQRR", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Insulin-like that are essential for its biological function; 2. The protein should be classified within Insulin-like_sf sharing conserved structural features; 3. The protein should contain Insulin_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MPRTFLVVLIYILAGFLCSTSALRKVNEASGIKTDGSGYTIVEECCTESCKLEEVNEYCHLFRGRFFCGEQILDIYNTVCNPRSIRRKRSLTVDKREAKKFIRQRR" }, { "InterPro": [ { "InterPro-ID": "IPR001194", "InterPro-Name": "cDENN_dom", "InterPro-Type": "DOMAIN", "Beg": 212, "End": 409 }, { "InterPro-ID": "IPR043153", "InterPro-Name": "DENN_C", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 304, "End": 445 }, { "InterPro-ID": "IPR005112", "InterPro-Name": "dDENN_dom", "InterPro-Type": "DOMAIN", "Beg": 758, "End": 807 }, { "InterPro-ID": "IPR051696", "InterPro-Name": "DENN_Domain_GEFs", "InterPro-Type": "FAMILY", "Beg": 720, "End": 812 }, { "InterPro-ID": "IPR037516", "InterPro-Name": "Tripartite_DENN", "InterPro-Type": "DOMAIN", "Beg": 19, "End": 799 }, { "InterPro-ID": "IPR005112", "InterPro-Name": "dDENN_dom", "InterPro-Type": "DOMAIN", "Beg": 719, "End": 791 }, { "InterPro-ID": "IPR046349", "InterPro-Name": "C1-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 656, "End": 715 }, { "InterPro-ID": "IPR002219", "InterPro-Name": "PE/DAG-bd", "InterPro-Type": "DOMAIN", "Beg": 666, "End": 714 }, { "InterPro-ID": "IPR005113", "InterPro-Name": "uDENN_dom", "InterPro-Type": "DOMAIN", "Beg": 39, "End": 105 }, { "InterPro-ID": "IPR005113", "InterPro-Name": "uDENN_dom", "InterPro-Type": "DOMAIN", "Beg": 8, "End": 107 } ], "response#1": "MIASIRTTRRLSNYNSVIPPPEPLNTDPDMHPLKRRFEPVLLDRYPPQEATDEITRRGKFPDYVPMFAFPNDIQIVSSDDRPRSTWHGFTMTSDDNSKLYGITIIIWTALNAEVAEEVEKKCEQWRQSHMSEEERELAASLGVRLAGERTHLSQLLAKLPTIPSGSPARERLEDEISTVEEKITLMTDMLRPLRHGAASKIEGLTAGESGLWTPRAYGILGRDAANMSFWKEWLKAIVTPMTDGGVLRIPPSSPSVGRWQPLERYVVNLCTEAFNPLGSKTQVELGVRELRLYARKEADNEIPGSRSIDLYALFRCLSLENIVALFEYAMAESRIIFLSSHTSMLHLACHALANLLYPLKWSSIFIPVLPARLLSALEAPCPYIVGIERRYDRIELPEDDYVLVDLDKDTIDATSQPVRLPRQARRKLMSLLQVAAPHKLRYGVTTGPPPYAMESFPYDAFSTENAALFRSATPKSTLGKWVSQSSSGFGEPDPPNEVLPPLFNAFASAKVDNGKSDRPSTSKSGKTSPQSSVSPVSINFPPMPSTPVSRSDSGFALAATLREKRSGHFGEEKMRRSSSFGIDKHPPYHKPNLPFLNGHQANLSISAISVDSQNSVVGGGSSGGGGYGNGYAPSTYAQSTLAASTIMPSMQIQPVRNTETTVWVEGHCFNWIPKDNTSICNICNDHAEGDGIYKCTGCKIFSHGRCLGHASLVCPEAFHPDRIRAAFVRCLASLLYTYRKYLGRPSKQQKANGQLYAFDMDGFIKSLPHDQHDYATMMRETQCFNEFIHDREMQPANNASIRVFDEIIMAKKARGRSGLSTGLSRLSTIRASHGASTYGGYAPPRGSSNSKIPAWLGDTSDHIWRTASVPLPKGNFPGEYRTVVTRTPARLDRSLMREPRSIQGMPRVEGRGARGLIRKQVPSMLGTTPPT", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more cDENN_dom, dDENN_dom, Tripartite_DENN, dDENN_dom, PE/DAG-bd, uDENN_dom, uDENN_dom that are essential for its biological function; 2. The protein should belong to DENN_Domain_GEFs that shares evolutionary origin and functional similarity; 3. The protein should be classified within DENN_C, C1-like_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MIASIRTTRRLSNYNSVIPPPEPLNTDPDMHPLKRRFEPVLLDRYPPQEATDEITRRGKFPDYVPMFAFPNDIQIVSSDDRPRSTWHGFTMTSDDNSKLYGITIIIWTALNAEVAEEVEKKCEQWRQSHMSEEERELAASLGVRLAGERTHLSQLLAKLPTIPSGSPARERLEDEISTVEEKITLMTDMLRPLRHGAASKIEGLTAGESGLWTPRAYGILGRDAANMSFWKEWLKAIVTPMTDGGVLRIPPSSPSVGRWQPLERYVVNLCTEAFNPLGSKTQVELGVRELRLYARKEADNEIPGSRSIDLYALFRCLSLENIVALFEYAMAESRIIFLSSHTSMLHLACHALANLLYPLKWSSIFIPVLPARLLSALEAPCPYIVGIERRYDRIELPEDDYVLVDLDKDTIDATSQPVRLPRQARRKLMSLLQVAAPHKLRYGVTTGPPPYAMESFPYDAFSTENAALFRSATPKSTLGKWVSQSSSGFGEPDPPNEVLPPLFNAFASAKVDNGKSDRPSTSKSGKTSPQSSVSPVSINFPPMPSTPVSRSDSGFALAATLREKRSGHFGEEKMRRSSSFGIDKHPPYHKPNLPFLNGHQANLSISAISVDSQNSVVGGGSSGGGGYGNGYAPSTYAQSTLAASTIMPSMQIQPVRNTETTVWVEGHCFNWIPKDNTSICNICNDHAEGDGIYKCTGCKIFSHGRCLGHASLVCPEAFHPDRIRAAFVRCLASLLYTYRKYLGRPSKQQKANGQLYAFDMDGFIKSLPHDQHDYATMMRETQCFNEFIHDREMQPANNASIRVFDEIIMAKKARGRSGLSTGLSRLSTIRASHGASTYGGYAPPRGSSNSKIPAWLGDTSDHIWRTASVPLPKGNFPGEYRTVVTRTPARLDRSLMREPRSIQGMPRVEGRGARGLIRKQVPSMLGTTPPT" }, { "InterPro": [ { "InterPro-ID": "IPR001077", "InterPro-Name": "O_MeTrfase_dom", "InterPro-Type": "DOMAIN", "Beg": 153, "End": 371 }, { "InterPro-ID": "IPR036390", "InterPro-Name": "WH_DNA-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 63, "End": 130 }, { "InterPro-ID": "IPR016461", "InterPro-Name": "COMT-like", "InterPro-Type": "FAMILY", "Beg": 56, "End": 396 }, { "InterPro-ID": "IPR036388", "InterPro-Name": "WH-like_DNA-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 49, "End": 131 }, { "InterPro-ID": "IPR029063", "InterPro-Name": "SAM-dependent_MTases_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 135, "End": 395 }, { "InterPro-ID": "IPR029063", "InterPro-Name": "SAM-dependent_MTases_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 138, "End": 373 } ], "response#1": "MVCVPSSSSVMELANLISQSIPKLQDESPQRANDARGNVIEACSKMLALVTSPAEMLKEMVLINLASLQVINHYQIASVVPLNGHIPISELANKCGLPVDILRRILRQAMTYGAFSEPEPDCIAQTDVSREIPRLSPLLTYQLDVCLPSMVRLLDWLKDVDGEHACAYQIAHDTKDTWWSYASKRPELIENYGKYMALITSGGAHDVSYVLKGFAWEKLGNAVVVDVGGADGFVGISLAKEYPNLAVIVEDNLGLKDSADDNIPQHLKSRVVFLPHSFFKPQSALSRDADVFLLRHILHDWNDNDCRAILQALAASMKPGASILVAEQILQRPGAASWQRERVMRALDMQMMIQFGSKERAYEDWDALFKSVDPPLEIVDCVQPVGSADSFMELKRRA", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more O_MeTrfase_dom that are essential for its biological function; 2. The protein should belong to COMT-like that shares evolutionary origin and functional similarity; 3. The protein should be classified within WH_DNA-bd_sf, WH-like_DNA-bd_sf, SAM-dependent_MTases_sf, SAM-dependent_MTases_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MVCVPSSSSVMELANLISQSIPKLQDESPQRANDARGNVIEACSKMLALVTSPAEMLKEMVLINLASLQVINHYQIASVVPLNGHIPISELANKCGLPVDILRRILRQAMTYGAFSEPEPDCIAQTDVSREIPRLSPLLTYQLDVCLPSMVRLLDWLKDVDGEHACAYQIAHDTKDTWWSYASKRPELIENYGKYMALITSGGAHDVSYVLKGFAWEKLGNAVVVDVGGADGFVGISLAKEYPNLAVIVEDNLGLKDSADDNIPQHLKSRVVFLPHSFFKPQSALSRDADVFLLRHILHDWNDNDCRAILQALAASMKPGASILVAEQILQRPGAASWQRERVMRALDMQMMIQFGSKERAYEDWDALFKSVDPPLEIVDCVQPVGSADSFMELKRRA" }, { "InterPro": [ { "InterPro-ID": "IPR016285", "InterPro-Name": "Hemagglutn-neuramid", "InterPro-Type": "FAMILY", "Beg": 166, "End": 578 }, { "InterPro-ID": "IPR000665", "InterPro-Name": "Hemagglutn/HN", "InterPro-Type": "FAMILY", "Beg": 37, "End": 581 }, { "InterPro-ID": "IPR016285", "InterPro-Name": "Hemagglutn-neuramid", "InterPro-Type": "FAMILY", "Beg": 1, "End": 582 }, { "InterPro-ID": "IPR036278", "InterPro-Name": "Sialidase_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 133, "End": 581 } ], "response#1": "MEPSKLFTISDNATFAPGPVINVADKKTFRTCFRILVLSVQAVTLILVIVNLGELVRMINDQGLSNQLSSITDKIRESANMIASAVGVMNQVIHGVTVSLPLQIEGNQNQLLSTLATICTSKKQVSNCSTNIPLVNDLRFINGINKFIIEDYATHDFSIGHPLNMPSFIPTATSPNGCTRIPSFSLGKTHWCYTHNVINANCKDHTSSNQYVSMGILVQTASGYPMFKTLKIQYLSDGLNRKSCSIATVPDGCAMYCYISTQLETDDYAGSSPPTQKLTLLFYNDTVTERTISPSGLEGNWATLVPGVGSGIYFENKLIFPAYGGVLPNSTLGVKSAREFFRPVNPYNPCSGPQQDLDQRALRSYFPSYFSNRRVQSAFLVCAWNQILVTNCELVVPSNNQTLMGAEGRVLLINNRLLYYQRSTSWWPYELLYEISFTFTNSGQSSVNMSWIPIYSFTRPGSGNCSGENVCPTACVSGVYLDPWPLTPYSHQSGINRNFYFTGALLNSSTTRVNPTLYVSALNNLKVLAPYGTQGLFASYTTTTCFQDTGDASVYCVYIMELASNIVGEFQILPVLTRLTIT", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Hemagglutn-neuramid, Hemagglutn/HN, Hemagglutn-neuramid that shares evolutionary origin and functional similarity; 2. The protein should be classified within Sialidase_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MEPSKLFTISDNATFAPGPVINVADKKTFRTCFRILVLSVQAVTLILVIVNLGELVRMINDQGLSNQLSSITDKIRESANMIASAVGVMNQVIHGVTVSLPLQIEGNQNQLLSTLATICTSKKQVSNCSTNIPLVNDLRFINGINKFIIEDYATHDFSIGHPLNMPSFIPTATSPNGCTRIPSFSLGKTHWCYTHNVINANCKDHTSSNQYVSMGILVQTASGYPMFKTLKIQYLSDGLNRKSCSIATVPDGCAMYCYISTQLETDDYAGSSPPTQKLTLLFYNDTVTERTISPSGLEGNWATLVPGVGSGIYFENKLIFPAYGGVLPNSTLGVKSAREFFRPVNPYNPCSGPQQDLDQRALRSYFPSYFSNRRVQSAFLVCAWNQILVTNCELVVPSNNQTLMGAEGRVLLINNRLLYYQRSTSWWPYELLYEISFTFTNSGQSSVNMSWIPIYSFTRPGSGNCSGENVCPTACVSGVYLDPWPLTPYSHQSGINRNFYFTGALLNSSTTRVNPTLYVSALNNLKVLAPYGTQGLFASYTTTTCFQDTGDASVYCVYIMELASNIVGEFQILPVLTRLTIT" }, { "InterPro": [ { "InterPro-ID": "IPR002021", "InterPro-Name": "Paramyx_ncap", "InterPro-Type": "FAMILY", "Beg": 30, "End": 403 } ], "response#1": "MSSVLKAFERFTIEQELQDRGEEGSIPPETLKSAVKVFVINTPNPTTRYQMLNFCLRIICSQNARASHRVGALITLFSLPSAGMQNHIRLADRSPEAQIERCEIDGFEPGTYRLIPNARANLTANEIAAYALLADDLPPTINNGTPYVHADVEGQPCDEIEQFLDRCYSVLIQAWVMVCKCMTAYDQPAGSADRRFAKYQQQGRLEARYMLQPEAQRLIQTAIRKSLVVRQYLTFELQLARRQGLLSNRYYAMVGDIGKYIENSGLTAFFLTLKYALGTKWSPLSLAAFTGELTKLRSLMMLYRGLGEQARYLALLEAPQIMDFAPGGYPLIFSYAMGVGTVLDVQMRNYTYARPFLNGYYFQIGVETARRQQGTVDNRVADDLGLTPEQRTEVTQLVDRLARGRGAGIPGGPVNPFVPPVQQQQPAAVYEDIPALEESDDDGDEDGGAGFQHGAQAPAVRQGGQNDFRAQPLQDPIQAQLFMPLYPQVSNIPNHQNHQINRIGGMEHQDLLRYNENGDSQQDARGEHGNTFPNNPNQNAQSQVGDWDE", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Paramyx_ncap that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MSSVLKAFERFTIEQELQDRGEEGSIPPETLKSAVKVFVINTPNPTTRYQMLNFCLRIICSQNARASHRVGALITLFSLPSAGMQNHIRLADRSPEAQIERCEIDGFEPGTYRLIPNARANLTANEIAAYALLADDLPPTINNGTPYVHADVEGQPCDEIEQFLDRCYSVLIQAWVMVCKCMTAYDQPAGSADRRFAKYQQQGRLEARYMLQPEAQRLIQTAIRKSLVVRQYLTFELQLARRQGLLSNRYYAMVGDIGKYIENSGLTAFFLTLKYALGTKWSPLSLAAFTGELTKLRSLMMLYRGLGEQARYLALLEAPQIMDFAPGGYPLIFSYAMGVGTVLDVQMRNYTYARPFLNGYYFQIGVETARRQQGTVDNRVADDLGLTPEQRTEVTQLVDRLARGRGAGIPGGPVNPFVPPVQQQQPAAVYEDIPALEESDDDGDEDGGAGFQHGAQAPAVRQGGQNDFRAQPLQDPIQAQLFMPLYPQVSNIPNHQNHQINRIGGMEHQDLLRYNENGDSQQDARGEHGNTFPNNPNQNAQSQVGDWDE" }, { "InterPro": [ { "InterPro-ID": "IPR024279", "InterPro-Name": "Paramyx_V_Zn-bd", "InterPro-Type": "DOMAIN", "Beg": 175, "End": 218 } ], "response#1": "MDQFIKQDETGDLIETGMNVANHFLSAPIQGTNSLSKATIIPGVAPVLIGNPEQKNIQYPTASHQGSKSKGRGSGAKPIIVSSSEGGTGGTQIPEPLFAQTGQGGVVTTVYQDPTIQPTGSYRSVELAKIGKERMINRFVEKPRTSTPVTEFKRGAGNGSPRPDNPRGGHRREWSLSWVQGEVRVFEWCNPICSPITAAARFHSCKCGNCPAKCDQCERDYGPP", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Paramyx_V_Zn-bd that are essential for its biological function. The designed protein sequence is ", "reference": "MDQFIKQDETGDLIETGMNVANHFLSAPIQGTNSLSKATIIPGVAPVLIGNPEQKNIQYPTASHQGSKSKGRGSGAKPIIVSSSEGGTGGTQIPEPLFAQTGQGGVVTTVYQDPTIQPTGSYRSVELAKIGKERMINRFVEKPRTSTPVTEFKRGAGNGSPRPDNPRGGHRREWSLSWVQGEVRVFEWCNPICSPITAAARFHSCKCGNCPAKCDQCERDYGPP" }, { "InterPro": [ { "InterPro-ID": "IPR039020", "InterPro-Name": "PaxB-like", "InterPro-Type": "FAMILY", "Beg": 16, "End": 240 }, { "InterPro-ID": "IPR039020", "InterPro-Name": "PaxB-like", "InterPro-Type": "FAMILY", "Beg": 13, "End": 235 } ], "response#1": "MFSNLHLPLNPIDKVNQPPVYYLQVQDGLIICSGLCWTTAYILYIRQAYRDKSYGMPLVCLCANIAWEFLFGAAIPESAAQVVSFFPWFVIDIGIVYTTWKFGREQWKHAPLVAQNLGWILLGGIAGMLVMFWAFLKTYDNRYEAGFYLAWTDQIIVSTTSVAQLMSRNNTSGHSWGIWFTRWIGSVFAELIFVWRYWNYPESYPVAATHVTIFLFIVTEVADLTYPFVYASLDKKEKKKLK", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to PaxB-like, PaxB-like that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MFSNLHLPLNPIDKVNQPPVYYLQVQDGLIICSGLCWTTAYILYIRQAYRDKSYGMPLVCLCANIAWEFLFGAAIPESAAQVVSFFPWFVIDIGIVYTTWKFGREQWKHAPLVAQNLGWILLGGIAGMLVMFWAFLKTYDNRYEAGFYLAWTDQIIVSTTSVAQLMSRNNTSGHSWGIWFTRWIGSVFAELIFVWRYWNYPESYPVAATHVTIFLFIVTEVADLTYPFVYASLDKKEKKKLK" }, { "InterPro": [ { "InterPro-ID": "IPR007166", "InterPro-Name": "Class3_signal_pept_motif", "InterPro-Type": "CONSERVED_SITE", "Beg": 2, "End": 27 } ], "response#1": "MSKGQVSVEFIVLFLALLVAVVVSTMTPGIFGLNKSVELSSASLAHAALSKVKSNIEILSVSGEGSYKLVYVKSPPANWTFENRTIRVYGNGFNISTNTSVDLNTYNYLASSLKILSVNLTRNDKNVTVAIQ", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain Class3_signal_pept_motif that is preserved across related proteins. The designed protein sequence is ", "reference": "MSKGQVSVEFIVLFLALLVAVVVSTMTPGIFGLNKSVELSSASLAHAALSKVKSNIEILSVSGEGSYKLVYVKSPPANWTFENRTIRVYGNGFNISTNTSVDLNTYNYLASSLKILSVNLTRNDKNVTVAIQ" }, { "InterPro": [ { "InterPro-ID": "IPR016179", "InterPro-Name": "Insulin-like", "InterPro-Type": "DOMAIN", "Beg": 41, "End": 112 }, { "InterPro-ID": "IPR036438", "InterPro-Name": "Insulin-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 37, "End": 112 }, { "InterPro-ID": "IPR022353", "InterPro-Name": "Insulin_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 98, "End": 112 }, { "InterPro-ID": "IPR016179", "InterPro-Name": "Insulin-like", "InterPro-Type": "DOMAIN", "Beg": 42, "End": 112 } ], "response#1": "MFYLTFLLFGAICIGQIQLGQPVKFKVNEDGHRPSVYPIKYRVCGWEIFARYLAICHIRQRRRKRSIEADIITDKDTANSYFNRVKRGSGRFNIVEECCLEGCIPEEIREYCP", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Insulin-like, Insulin-like that are essential for its biological function; 2. The protein should be classified within Insulin-like_sf sharing conserved structural features; 3. The protein should contain Insulin_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MFYLTFLLFGAICIGQIQLGQPVKFKVNEDGHRPSVYPIKYRVCGWEIFARYLAICHIRQRRRKRSIEADIITDKDTANSYFNRVKRGSGRFNIVEECCLEGCIPEEIREYCP" }, { "InterPro": [ { "InterPro-ID": "IPR022352", "InterPro-Name": "Insulin_family", "InterPro-Type": "FAMILY", "Beg": 101, "End": 120 }, { "InterPro-ID": "IPR022352", "InterPro-Name": "Insulin_family", "InterPro-Type": "FAMILY", "Beg": 50, "End": 66 }, { "InterPro-ID": "IPR036438", "InterPro-Name": "Insulin-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 44, "End": 120 }, { "InterPro-ID": "IPR016179", "InterPro-Name": "Insulin-like", "InterPro-Type": "DOMAIN", "Beg": 51, "End": 120 }, { "InterPro-ID": "IPR016179", "InterPro-Name": "Insulin-like", "InterPro-Type": "DOMAIN", "Beg": 49, "End": 120 }, { "InterPro-ID": "IPR016724", "InterPro-Name": "Insulin-rel_pep", "InterPro-Type": "FAMILY", "Beg": 68, "End": 121 }, { "InterPro-ID": "IPR016724", "InterPro-Name": "Insulin-rel_pep", "InterPro-Type": "FAMILY", "Beg": 2, "End": 80 }, { "InterPro-ID": "IPR022353", "InterPro-Name": "Insulin_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 106, "End": 120 } ], "response#1": "MDSFTRASLITFLILLTLTSLVFSNGCMMRGGCFKTSEDAHRLIMQVDFYICGNAIFDTFMDVCRPGPRRRKRDLRRKLGIVMDRKESHKFLRRRKRRVYDIVEECCMEGCIVEEVSEYCD", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Insulin-like, Insulin-like that are essential for its biological function; 2. The protein should belong to Insulin_family, Insulin_family, Insulin-rel_pep, Insulin-rel_pep that shares evolutionary origin and functional similarity; 3. The protein should be classified within Insulin-like_sf sharing conserved structural features; 4. The protein should contain Insulin_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MDSFTRASLITFLILLTLTSLVFSNGCMMRGGCFKTSEDAHRLIMQVDFYICGNAIFDTFMDVCRPGPRRRKRDLRRKLGIVMDRKESHKFLRRRKRRVYDIVEECCMEGCIVEEVSEYCD" }, { "InterPro": [ { "InterPro-ID": "IPR036438", "InterPro-Name": "Insulin-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 30, "End": 106 }, { "InterPro-ID": "IPR016179", "InterPro-Name": "Insulin-like", "InterPro-Type": "DOMAIN", "Beg": 35, "End": 106 }, { "InterPro-ID": "IPR016179", "InterPro-Name": "Insulin-like", "InterPro-Type": "DOMAIN", "Beg": 34, "End": 106 }, { "InterPro-ID": "IPR022352", "InterPro-Name": "Insulin_family", "InterPro-Type": "FAMILY", "Beg": 35, "End": 51 }, { "InterPro-ID": "IPR022352", "InterPro-Name": "Insulin_family", "InterPro-Type": "FAMILY", "Beg": 87, "End": 106 } ], "response#1": "MLFYFGLAVIFLIDSSQTQTLYKVNEVGGSQVDRNLCGSDIPTAIKDICGIKKRQNIPRKYGRDPNNILEKEEFAKRFLRVRRQTTDIVEECCVENCAIEEIAEYC", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Insulin-like, Insulin-like that are essential for its biological function; 2. The protein should belong to Insulin_family, Insulin_family that shares evolutionary origin and functional similarity; 3. The protein should be classified within Insulin-like_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MLFYFGLAVIFLIDSSQTQTLYKVNEVGGSQVDRNLCGSDIPTAIKDICGIKKRQNIPRKYGRDPNNILEKEEFAKRFLRVRRQTTDIVEECCVENCAIEEIAEYC" }, { "InterPro": [ { "InterPro-ID": "IPR001077", "InterPro-Name": "O_MeTrfase_dom", "InterPro-Type": "DOMAIN", "Beg": 184, "End": 395 }, { "InterPro-ID": "IPR029063", "InterPro-Name": "SAM-dependent_MTases_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 156, "End": 415 }, { "InterPro-ID": "IPR016461", "InterPro-Name": "COMT-like", "InterPro-Type": "FAMILY", "Beg": 72, "End": 421 }, { "InterPro-ID": "IPR029063", "InterPro-Name": "SAM-dependent_MTases_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 157, "End": 420 }, { "InterPro-ID": "IPR036388", "InterPro-Name": "WH-like_DNA-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 68, "End": 156 }, { "InterPro-ID": "IPR036390", "InterPro-Name": "WH_DNA-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 62, "End": 152 } ], "response#1": "MEELTRSLVNDVEVLNNHFVSTGHPLPSFDRHTPTVVLPNDASPDAHAARERILDNALRLFQLAAGPSAYLLNLQTGYQYASCVRWLCHFQIFHLVPLEGSIAYADLAVLAKAPEPQLISVVRMAMTNGLFLESPPQHLAHSATSALLRNDADFHDWAVTMSDLSFPTAFAMVEAHERWPNSVEGNQTAYNIAVGSELPFFSHLAEQSDRKRQFAGFMRSMARSQGTDVEKLAEGWDWAALGQACVVDVGGSTGHTSVALARKYPDLNFVVEDLPEVVAEGPGYLSYLDDAQDLKSRIGYRAHSFFDPQPVQDADVYMLRMILHNWSFDDCVRILSRLVQTLKPGARIIIVDIVLPDPGVVSASKERLLRVQDLIMQQVFNSMERYLENWMDIFRKVDERLEVKRIVEPPGSLMSLIELSMAA", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more O_MeTrfase_dom that are essential for its biological function; 2. The protein should belong to COMT-like that shares evolutionary origin and functional similarity; 3. The protein should be classified within SAM-dependent_MTases_sf, SAM-dependent_MTases_sf, WH-like_DNA-bd_sf, WH_DNA-bd_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MEELTRSLVNDVEVLNNHFVSTGHPLPSFDRHTPTVVLPNDASPDAHAARERILDNALRLFQLAAGPSAYLLNLQTGYQYASCVRWLCHFQIFHLVPLEGSIAYADLAVLAKAPEPQLISVVRMAMTNGLFLESPPQHLAHSATSALLRNDADFHDWAVTMSDLSFPTAFAMVEAHERWPNSVEGNQTAYNIAVGSELPFFSHLAEQSDRKRQFAGFMRSMARSQGTDVEKLAEGWDWAALGQACVVDVGGSTGHTSVALARKYPDLNFVVEDLPEVVAEGPGYLSYLDDAQDLKSRIGYRAHSFFDPQPVQDADVYMLRMILHNWSFDDCVRILSRLVQTLKPGARIIIVDIVLPDPGVVSASKERLLRVQDLIMQQVFNSMERYLENWMDIFRKVDERLEVKRIVEPPGSLMSLIELSMAA" }, { "InterPro": [ { "InterPro-ID": "IPR006080", "InterPro-Name": "Beta/alpha-defensin_C", "InterPro-Type": "DOMAIN", "Beg": 31, "End": 60 } ], "response#1": "MRLHLLLLILLLFKILLSPVRGDLGPVEGHCLNLSGVCRRDVCKVVEDQIGACRRRMKCCRAWWILMPIPTPLIMSDYQEPLKPKLK", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Beta/alpha-defensin_C that are essential for its biological function. The designed protein sequence is ", "reference": "MRLHLLLLILLLFKILLSPVRGDLGPVEGHCLNLSGVCRRDVCKVVEDQIGACRRRMKCCRAWWILMPIPTPLIMSDYQEPLKPKLK" }, { "InterPro": [ { "InterPro-ID": "IPR006162", "InterPro-Name": "Ppantetheine_attach_site", "InterPro-Type": "PTM", "Beg": 1795, "End": 1810 }, { "InterPro-ID": "IPR049900", "InterPro-Name": "PKS_mFAS_DH", "InterPro-Type": "DOMAIN", "Beg": 1302, "End": 1608 }, { "InterPro-ID": "IPR014030", "InterPro-Name": "Ketoacyl_synth_N", "InterPro-Type": "DOMAIN", "Beg": 387, "End": 636 }, { "InterPro-ID": "IPR009081", "InterPro-Name": "PP-bd_ACP", "InterPro-Type": "DOMAIN", "Beg": 1646, "End": 1723 }, { "InterPro-ID": "IPR016039", "InterPro-Name": "Thiolase-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 384, "End": 760 }, { "InterPro-ID": "IPR009081", "InterPro-Name": "PP-bd_ACP", "InterPro-Type": "DOMAIN", "Beg": 1772, "End": 1836 }, { "InterPro-ID": "IPR009081", "InterPro-Name": "PP-bd_ACP", "InterPro-Type": "DOMAIN", "Beg": 1653, "End": 1715 }, { "InterPro-ID": "IPR036736", "InterPro-Name": "ACP-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1649, "End": 1720 }, { "InterPro-ID": "IPR036736", "InterPro-Name": "ACP-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1768, "End": 1837 }, { "InterPro-ID": "IPR018201", "InterPro-Name": "Ketoacyl_synth_AS", "InterPro-Type": "ACTIVE_SITE", "Beg": 549, "End": 565 }, { "InterPro-ID": "IPR006162", "InterPro-Name": "Ppantetheine_attach_site", "InterPro-Type": "PTM", "Beg": 1678, "End": 1693 }, { "InterPro-ID": "IPR014031", "InterPro-Name": "Ketoacyl_synth_C", "InterPro-Type": "DOMAIN", "Beg": 645, "End": 763 }, { "InterPro-ID": "IPR014043", "InterPro-Name": "Acyl_transferase_dom", "InterPro-Type": "DOMAIN", "Beg": 921, "End": 1239 }, { "InterPro-ID": "IPR016039", "InterPro-Name": "Thiolase-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 383, "End": 826 }, { "InterPro-ID": "IPR042104", "InterPro-Name": "PKS_dehydratase_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1295, "End": 1612 }, { "InterPro-ID": "IPR030918", "InterPro-Name": "PT_fungal_PKS", "InterPro-Type": "DOMAIN", "Beg": 1299, "End": 1612 }, { "InterPro-ID": "IPR001227", "InterPro-Name": "Ac_transferase_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 920, "End": 1223 }, { "InterPro-ID": "IPR036736", "InterPro-Name": "ACP-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1648, "End": 1722 }, { "InterPro-ID": "IPR016036", "InterPro-Name": "Malonyl_transacylase_ACP-bd", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1047, "End": 1105 }, { "InterPro-ID": "IPR029058", "InterPro-Name": "AB_hydrolase_fold", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1861, "End": 2113 }, { "InterPro-ID": "IPR029058", "InterPro-Name": "AB_hydrolase_fold", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1855, "End": 2116 }, { "InterPro-ID": "IPR050091", "InterPro-Name": "PKS_NRPS_Biosynth_Enz", "InterPro-Type": "FAMILY", "Beg": 385, "End": 1642 }, { "InterPro-ID": "IPR049551", "InterPro-Name": "PKS_DH_C", "InterPro-Type": "DOMAIN", "Beg": 1463, "End": 1604 }, { "InterPro-ID": "IPR020841", "InterPro-Name": "PKS_Beta-ketoAc_synthase_dom", "InterPro-Type": "DOMAIN", "Beg": 389, "End": 820 }, { "InterPro-ID": "IPR020806", "InterPro-Name": "PKS_PP-bd", "InterPro-Type": "DOMAIN", "Beg": 1652, "End": 1723 }, { "InterPro-ID": "IPR020806", "InterPro-Name": "PKS_PP-bd", "InterPro-Type": "DOMAIN", "Beg": 1769, "End": 1840 }, { "InterPro-ID": "IPR016035", "InterPro-Name": "Acyl_Trfase/lysoPLipase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 919, "End": 1208 }, { "InterPro-ID": "IPR014043", "InterPro-Name": "Acyl_transferase_dom", "InterPro-Type": "DOMAIN", "Beg": 922, "End": 1220 }, { "InterPro-ID": "IPR009081", "InterPro-Name": "PP-bd_ACP", "InterPro-Type": "DOMAIN", "Beg": 1763, "End": 1840 }, { "InterPro-ID": "IPR001031", "InterPro-Name": "Thioesterase", "InterPro-Type": "DOMAIN", "Beg": 1872, "End": 1976 }, { "InterPro-ID": "IPR001227", "InterPro-Name": "Ac_transferase_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 3, "End": 155 }, { "InterPro-ID": "IPR020841", "InterPro-Name": "PKS_Beta-ketoAc_synthase_dom", "InterPro-Type": "DOMAIN", "Beg": 386, "End": 817 }, { "InterPro-ID": "IPR032088", "InterPro-Name": "SAT", "InterPro-Type": "DOMAIN", "Beg": 5, "End": 258 }, { "InterPro-ID": "IPR036736", "InterPro-Name": "ACP-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1768, "End": 1844 } ], "response#1": "MVNIYIFGDQTVRVDDAVHKLLHVKNNPILKSFLDGSFAAIRKQIFLLPANERTSLPDAHTLPLLLEAVRRGRRHVALESALVCLCEIGQYIALLQTTDLCHPPTGSILVGFCTGSLAAAAVSCVRTSIDLLTLGIEAVVVAFRVGMHVARRANALGGDGGSQWKPWSLAVTDGSESETEKILEEFTRDEVSGVHVANRHDAYILAKGLPAIMKPYVSAAGSNTLTISGTPRVLEALKASPHLRGTKSLPVSIYAPYHAAHLYNEADVESIFACKPVESALFHRELRTPLISCATGTVLKEKTFGDLLRALVMEILTCQIRFDKVEESIVQHTPGATAQLIPIHTNIAPRMKTSLTQVGLQVECFKAIANQEPAAEALSESPSNDSSKIAIIGFSGRFPEADGLNEFWELLQQGLDVHKPIPADRFDLEAHYDATLREKNTSRIKHGCWIRSPGSFDARFFQMSPREACQTDPAQRLALLTAYEAMEMAGFVPDRTPSSQRDRVGVYYGMTSDDWREVNSSQDIDTYFIPGGIRAFVPGRINYFFKFSGPSITVDTACSSSLAAIHTACNALLNSDCDTALAGGTNILTNPDNFAGLDRGHFLSSTGNCKTFDDDADGYCRADGVGTVILKRLQDAIADNDPIFGVIVGARTSHSAEAVSITRPLADAQAHLFRKLLAESGIHPHEISYIEMHGTGTQAGDAVEMKSVLDSFARDDSRAPDRPLHLGSVKANVGHGESASGVTALIKVLLMMQKNRIPPHCGIKGRINRHFPTDMEYRNVHIPFMETDWTRPQEGKRRSFINNFSAAGGNTAVLVEDAPLLEQSRAISSPDPQRYHVITLSARSVRSLSKNMRALGEFIGSETSPGLLARIAYTTTARRMHHSYRVAFVGNDLQEVKRRFLDTDVTEAIKPCPTKSPGVGFLFTGQGAQQTAMARELYDRFTSFRADILEFEAVGRGHGFPSILPLITGAVDVEELSPMIVQLGTVVIQIAMARLWQTWGLTPEYALGHSLGEYAALQIAGVLSISDTIYLAGSRAALLEKRCTAGSHGMLAVKASVAHLEEALKGMQVEVSCINGFDDTVLSGTNDEIDRASKELSELKVTFKRLILPFAFHSSQVDPILEELEHIASQLSFQPPRIPIVSPTVGHIITDEGTIGAQYIRRHCREPVNFLGAIQAAQGSGICNSGALAVEIGAHPILTRMMKAAVGSSVTVCSTLSHREDMFKTLTESLSVLHLAGVRLNWDEYHRDFNNQVVMLPAYSWDYQDYWIQYQNNFCLTKGSPERSESVDAIQPMSTRLSPSVQKILEEEMTAAQASIIIESDITDPELLPVALDHKVNGVTLCPSSLYADIGHTLGTYLLGKKEDVTDYKIDVSNMAVEKALVVKGTGPQLFRASLDMDWNMLRGMMKVYSVNNMGTLTTHHAQCTIELQRPHQWQEGWNRQLYLIQRSIEQLKKGVEEGWTHKMRRGVAYRLFSSMMQYGPSYQAMEEVIFDSSGLEATAQVRLQSTTGRYSFNPVWSDSLGHITGFVTNCNDSIDLTENLFVNHGWGFMRCVEPFSPDTVYQTHVKMQPVDGNNGFYVGDVYVLNDHRIIAQYGAVTFQKVARRVLEMLLPATTSKGRSSNIRPRNVGTAQSAKIVQSKRRTQTPHVEDAWQQVLEMIARELGVDPGQLTEDVNFTDMGVDSLMSLTIIGNFREFLSLDVPWSLFEDCPSVQSLRIYLNMSSLSESDSIETSSYPTPDESTTTTITSPSGSDRNVGRNSGIDGVGTTVGLVLSILAEEIGVNVRDLSNADGLSELGLDSLLSITALGRVRDETDLDLPSDFFLEHSSVAAITAALHAIFGSTEQGPEQSLITSHPPAMSINLQGDEGCPQTLFLFPDGSGSSTSYSALPTISKDVRVYAMDCPYLKRPNELAKCQLQDLTPVYVAEIRRRQLRGPYSLGGWSAGGIAAYEAAQYLVDQGERVERLILIDSPNPMGLGKCPPHFYRFLEEAGVFGVHGGRKPPAWLLQHFQAFNDVLSQYTLEPFRPADATPNTTLIYAQDGVCKSPRDPRPERHPGDPEVFSWLLENRVDMSCNGWDQLLGEDNIHLGTVFDANHFTIVRTPAVVRLSEIVRMAMSRKFQ", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more PKS_mFAS_DH, Ketoacyl_synth_N, PP-bd_ACP, PP-bd_ACP, PP-bd_ACP, Ketoacyl_synth_C, Acyl_transferase_dom, PT_fungal_PKS, PKS_DH_C, PKS_Beta-ketoAc_synthase_dom, PKS_PP-bd, PKS_PP-bd, Acyl_transferase_dom, PP-bd_ACP, Thioesterase, PKS_Beta-ketoAc_synthase_dom, SAT that are essential for its biological function; 2. The protein should belong to PKS_NRPS_Biosynth_Enz that shares evolutionary origin and functional similarity; 3. The protein should be classified within Thiolase-like, ACP-like_sf, ACP-like_sf, Thiolase-like, PKS_dehydratase_sf, Ac_transferase_dom_sf, ACP-like_sf, Malonyl_transacylase_ACP-bd, AB_hydrolase_fold, AB_hydrolase_fold, Acyl_Trfase/lysoPLipase, Ac_transferase_dom_sf, ACP-like_sf sharing conserved structural features; 4. The protein must have Ketoacyl_synth_AS that is conserved among related catalytic enzymes; 5. The protein should contain Ppantetheine_attach_site, Ppantetheine_attach_site that allow regulation through chemical modifications. The designed protein sequence is ", "reference": "MVNIYIFGDQTVRVDDAVHKLLHVKNNPILKSFLDGSFAAIRKQIFLLPANERTSLPDAHTLPLLLEAVRRGRRHVALESALVCLCEIGQYIALLQTTDLCHPPTGSILVGFCTGSLAAAAVSCVRTSIDLLTLGIEAVVVAFRVGMHVARRANALGGDGGSQWKPWSLAVTDGSESETEKILEEFTRDEVSGVHVANRHDAYILAKGLPAIMKPYVSAAGSNTLTISGTPRVLEALKASPHLRGTKSLPVSIYAPYHAAHLYNEADVESIFACKPVESALFHRELRTPLISCATGTVLKEKTFGDLLRALVMEILTCQIRFDKVEESIVQHTPGATAQLIPIHTNIAPRMKTSLTQVGLQVECFKAIANQEPAAEALSESPSNDSSKIAIIGFSGRFPEADGLNEFWELLQQGLDVHKPIPADRFDLEAHYDATLREKNTSRIKHGCWIRSPGSFDARFFQMSPREACQTDPAQRLALLTAYEAMEMAGFVPDRTPSSQRDRVGVYYGMTSDDWREVNSSQDIDTYFIPGGIRAFVPGRINYFFKFSGPSITVDTACSSSLAAIHTACNALLNSDCDTALAGGTNILTNPDNFAGLDRGHFLSSTGNCKTFDDDADGYCRADGVGTVILKRLQDAIADNDPIFGVIVGARTSHSAEAVSITRPLADAQAHLFRKLLAESGIHPHEISYIEMHGTGTQAGDAVEMKSVLDSFARDDSRAPDRPLHLGSVKANVGHGESASGVTALIKVLLMMQKNRIPPHCGIKGRINRHFPTDMEYRNVHIPFMETDWTRPQEGKRRSFINNFSAAGGNTAVLVEDAPLLEQSRAISSPDPQRYHVITLSARSVRSLSKNMRALGEFIGSETSPGLLARIAYTTTARRMHHSYRVAFVGNDLQEVKRRFLDTDVTEAIKPCPTKSPGVGFLFTGQGAQQTAMARELYDRFTSFRADILEFEAVGRGHGFPSILPLITGAVDVEELSPMIVQLGTVVIQIAMARLWQTWGLTPEYALGHSLGEYAALQIAGVLSISDTIYLAGSRAALLEKRCTAGSHGMLAVKASVAHLEEALKGMQVEVSCINGFDDTVLSGTNDEIDRASKELSELKVTFKRLILPFAFHSSQVDPILEELEHIASQLSFQPPRIPIVSPTVGHIITDEGTIGAQYIRRHCREPVNFLGAIQAAQGSGICNSGALAVEIGAHPILTRMMKAAVGSSVTVCSTLSHREDMFKTLTESLSVLHLAGVRLNWDEYHRDFNNQVVMLPAYSWDYQDYWIQYQNNFCLTKGSPERSESVDAIQPMSTRLSPSVQKILEEEMTAAQASIIIESDITDPELLPVALDHKVNGVTLCPSSLYADIGHTLGTYLLGKKEDVTDYKIDVSNMAVEKALVVKGTGPQLFRASLDMDWNMLRGMMKVYSVNNMGTLTTHHAQCTIELQRPHQWQEGWNRQLYLIQRSIEQLKKGVEEGWTHKMRRGVAYRLFSSMMQYGPSYQAMEEVIFDSSGLEATAQVRLQSTTGRYSFNPVWSDSLGHITGFVTNCNDSIDLTENLFVNHGWGFMRCVEPFSPDTVYQTHVKMQPVDGNNGFYVGDVYVLNDHRIIAQYGAVTFQKVARRVLEMLLPATTSKGRSSNIRPRNVGTAQSAKIVQSKRRTQTPHVEDAWQQVLEMIARELGVDPGQLTEDVNFTDMGVDSLMSLTIIGNFREFLSLDVPWSLFEDCPSVQSLRIYLNMSSLSESDSIETSSYPTPDESTTTTITSPSGSDRNVGRNSGIDGVGTTVGLVLSILAEEIGVNVRDLSNADGLSELGLDSLLSITALGRVRDETDLDLPSDFFLEHSSVAAITAALHAIFGSTEQGPEQSLITSHPPAMSINLQGDEGCPQTLFLFPDGSGSSTSYSALPTISKDVRVYAMDCPYLKRPNELAKCQLQDLTPVYVAEIRRRQLRGPYSLGGWSAGGIAAYEAAQYLVDQGERVERLILIDSPNPMGLGKCPPHFYRFLEEAGVFGVHGGRKPPAWLLQHFQAFNDVLSQYTLEPFRPADATPNTTLIYAQDGVCKSPRDPRPERHPGDPEVFSWLLENRVDMSCNGWDQLLGEDNIHLGTVFDANHFTIVRTPAVVRLSEIVRMAMSRKFQ" }, { "InterPro": [ { "InterPro-ID": "IPR036864", "InterPro-Name": "Zn2-C6_fun-type_DNA-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 13, "End": 57 }, { "InterPro-ID": "IPR036864", "InterPro-Name": "Zn2-C6_fun-type_DNA-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 14, "End": 50 }, { "InterPro-ID": "IPR050675", "InterPro-Name": "OAF3", "InterPro-Type": "FAMILY", "Beg": 8, "End": 381 }, { "InterPro-ID": "IPR013700", "InterPro-Name": "AflR", "InterPro-Type": "DOMAIN", "Beg": 208, "End": 300 }, { "InterPro-ID": "IPR001138", "InterPro-Name": "Zn2Cys6_DnaBD", "InterPro-Type": "DOMAIN", "Beg": 16, "End": 51 }, { "InterPro-ID": "IPR001138", "InterPro-Name": "Zn2Cys6_DnaBD", "InterPro-Type": "DOMAIN", "Beg": 15, "End": 59 }, { "InterPro-ID": "IPR001138", "InterPro-Name": "Zn2Cys6_DnaBD", "InterPro-Type": "DOMAIN", "Beg": 20, "End": 55 }, { "InterPro-ID": "IPR001138", "InterPro-Name": "Zn2Cys6_DnaBD", "InterPro-Type": "DOMAIN", "Beg": 20, "End": 48 }, { "InterPro-ID": "IPR001138", "InterPro-Name": "Zn2Cys6_DnaBD", "InterPro-Type": "DOMAIN", "Beg": 20, "End": 50 } ], "response#1": "MSTGSTLNQRSGKPVKLRASCDFCALSKVKCDRGQPQCVRCIKSGIDCNYSESRRIGKAWHHCAPSAVRSTSATTQGTRRKQQTIAQHSPRRRIHRDTQALSAADDAMSPYDPSGYATPFSMFHTLPSPVPESTIRSQTHIESYPSLDGTMAPILCSPESADISLPDIPHVAQLRTNELEGESPSVLQYNPSWDRIMAEHSTAIGDAGDCITRAAAVLKSVRDPRTSCVRSRTPPRSHTQSLDATLDDGRTAMDTVKDILACPCAQEIRVALLLVLIIQQVLESYQALLTQQHDTPREESPLGINLSRYDTPMAIGRYLLDNELRSKIIVQVLSSELEKIGLILDILTRHAQSMAHQPDELILGTYIDSLQTTKKEVLESLEQGNDI", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more AflR, Zn2Cys6_DnaBD, Zn2Cys6_DnaBD, Zn2Cys6_DnaBD, Zn2Cys6_DnaBD, Zn2Cys6_DnaBD that are essential for its biological function; 2. The protein should belong to OAF3 that shares evolutionary origin and functional similarity; 3. The protein should be classified within Zn2-C6_fun-type_DNA-bd_sf, Zn2-C6_fun-type_DNA-bd_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MSTGSTLNQRSGKPVKLRASCDFCALSKVKCDRGQPQCVRCIKSGIDCNYSESRRIGKAWHHCAPSAVRSTSATTQGTRRKQQTIAQHSPRRRIHRDTQALSAADDAMSPYDPSGYATPFSMFHTLPSPVPESTIRSQTHIESYPSLDGTMAPILCSPESADISLPDIPHVAQLRTNELEGESPSVLQYNPSWDRIMAEHSTAIGDAGDCITRAAAVLKSVRDPRTSCVRSRTPPRSHTQSLDATLDDGRTAMDTVKDILACPCAQEIRVALLLVLIIQQVLESYQALLTQQHDTPREESPLGINLSRYDTPMAIGRYLLDNELRSKIIVQVLSSELEKIGLILDILTRHAQSMAHQPDELILGTYIDSLQTTKKEVLESLEQGNDI" }, { "InterPro": [ { "InterPro-ID": "IPR007166", "InterPro-Name": "Class3_signal_pept_motif", "InterPro-Type": "CONSERVED_SITE", "Beg": 6, "End": 32 } ], "response#1": "MFKRFNRGQISFEFSIIVLSILLISTITITYFLTSSFDEGTRTLDKIDLGAKTAVSLVNSGYNGTQTEGTLIYAGMTWDNAGNNYENITVYISNTTPVPVNTRLFVKNYTIESQGIDTTKYDFTIAWSG", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain Class3_signal_pept_motif that is preserved across related proteins. The designed protein sequence is ", "reference": "MFKRFNRGQISFEFSIIVLSILLISTITITYFLTSSFDEGTRTLDKIDLGAKTAVSLVNSGYNGTQTEGTLIYAGMTWDNAGNNYENITVYISNTTPVPVNTRLFVKNYTIESQGIDTTKYDFTIAWSG" }, { "InterPro": [ { "InterPro-ID": "IPR017857", "InterPro-Name": "Coagulation_fac-like_Gla_dom", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 27, "End": 59 }, { "InterPro-ID": "IPR022353", "InterPro-Name": "Insulin_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 43, "End": 57 }, { "InterPro-ID": "IPR036438", "InterPro-Name": "Insulin-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 28, "End": 57 } ], "response#1": "MKTPILFVVVVAVLIVTDSAEGFKGKANSFLKPLQRRGLEEECCQETCSYHEIWENCKKLCSDELHKMFVEICQPPTEKVPERD", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should be classified within Coagulation_fac-like_Gla_dom, Insulin-like_sf sharing conserved structural features; 2. The protein should contain Insulin_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MKTPILFVVVVAVLIVTDSAEGFKGKANSFLKPLQRRGLEEECCQETCSYHEIWENCKKLCSDELHKMFVEICQPPTEKVPERD" }, { "InterPro": [ { "InterPro-ID": "IPR003582", "InterPro-Name": "ShKT_dom", "InterPro-Type": "DOMAIN", "Beg": 27, "End": 53 }, { "InterPro-ID": "IPR003582", "InterPro-Name": "ShKT_dom", "InterPro-Type": "DOMAIN", "Beg": 54, "End": 88 } ], "response#1": "MKTTLVVVVLACIVALTSALEADLLSHESCRYISSNRYCGHDYMDKLCNTTCNCKDVLSEFSCGVLKKDGQCNKADIQAKCKLTCDKC", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more ShKT_dom, ShKT_dom that are essential for its biological function. The designed protein sequence is ", "reference": "MKTTLVVVVLACIVALTSALEADLLSHESCRYISSNRYCGHDYMDKLCNTTCNCKDVLSEFSCGVLKKDGQCNKADIQAKCKLTCDKC" }, { "InterPro": [ { "InterPro-ID": "IPR008011", "InterPro-Name": "Complex1_LYR_dom", "InterPro-Type": "DOMAIN", "Beg": 8, "End": 67 }, { "InterPro-ID": "IPR051522", "InterPro-Name": "ISC_assembly_LYR", "InterPro-Type": "FAMILY", "Beg": 2, "End": 86 }, { "InterPro-ID": "IPR045297", "InterPro-Name": "Complex1_LYR_LYRM4", "InterPro-Type": "DOMAIN", "Beg": 8, "End": 78 } ], "response#1": "MNGNQIKQLKKLYRHILNEASKFENINYNVYFSNKAKEKFREFCSDTNFESEKLKTFQNECWDYLNMLKRQTIIHNLYHVDKPLVNK", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Complex1_LYR_dom, Complex1_LYR_LYRM4 that are essential for its biological function; 2. The protein should belong to ISC_assembly_LYR that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MNGNQIKQLKKLYRHILNEASKFENINYNVYFSNKAKEKFREFCSDTNFESEKLKTFQNECWDYLNMLKRQTIIHNLYHVDKPLVNK" }, { "InterPro": [ { "InterPro-ID": "IPR055385", "InterPro-Name": "GpJ_HDII-ins2", "InterPro-Type": "DOMAIN", "Beg": 96, "End": 222 }, { "InterPro-ID": "IPR015406", "InterPro-Name": "GpJ_CSF", "InterPro-Type": "DOMAIN", "Beg": 982, "End": 1117 }, { "InterPro-ID": "IPR053171", "InterPro-Name": "Viral_Tip_Attach_Protein", "InterPro-Type": "FAMILY", "Beg": 7, "End": 857 }, { "InterPro-ID": "IPR032876", "InterPro-Name": "J_dom", "InterPro-Type": "DOMAIN", "Beg": 344, "End": 496 } ], "response#1": "MTIVYDVTGHKGGGGKQHTPQETPDSLHSLAKIRILLALGEGEFEGITSASELRQRVYLDGTPIQNADLSENFPGARVEFRPGTQHQDVIHGFSAVESEQSVGVKLENGTPWVRQINDTSLDAVRVRIGIPALYTSEDNGDLVGGRIDYKIVVYTDNADPREFTFAAVGKTMSLYERDHRIELPPNVNTGWRVEVHRITADSTSAKVVNDIQVQSITEIIDARLRYPLTALLFVEFDAKAFQNIPRVSIKCKGRKVLIPNNYDPINHTYSGDWDGTFKRAWSDNPAWHWYDICITERFGLGRRIKPQMLNRYALYQIAQRCDQLVSDGNGGREIRFKNDMYIQSQTDAWTVLKDLAAIFAGMTWWGNQMLNIVSDQPVAAVSHTITNASVIDGRFDYASGSQKTRYSTFAVAYGNPKNHYDDAIATGQRVELVRRHKINRLDITAIGCTRESEAQRRGHWALISNQLDQQVSFKVGMEGLFFIPGSVVAIADTNISGGFETRGGRLLSDPGTRTVLNTDSEITFRPGDKFLVRTDSGNVETREIASVNGNKVTLKTALDADPIPDQPFCVDGDDIQLQKFRITDLEYDDSTSTFSVRGIEYNDSKYDAVDNGARLDPGIFTQVPDGVMKGPESVTITPSQISSQGQLITNVDIVFPPVKDAVVYEIQWRRTSLQNMAVQWGNDWVNIPRTASNGAHIPNVFSGNYQARVRAIGMGEISSPWVSSAITPVEGRLGGLNAPIITNAISGLHQILWKWNHNNAATDISYTELEVRKTGETEWKFLTNVPYPGAEYAQTSLEFGIYQQLRARVADKIGNLSDWSAPFEGQVSDKVDEYMKGLDDEFLTSEDGKRFQEAIDTVPQGIYEAMLTDAQQLFNARAEYKGIYAEIKVAYNVAADAHKAVAQLETLIGTRLDDAEAAIHTLQTAQSTQEQAFAQYQQTVAAKFSEQEAAIQQVQTATADVAGALAEYKTQVAAQFGQQSAAIEQKMTSSFNHAGGSATYSLKAGVTYNGTYYDAGMQLSVVTEGDAVKSSIAFKADQFYIMHPSNGSLSSAFIVDGGAVYIDTARIKDATINFAQITDTLQSNNYDGDTRGWRLGKDGTFINLGTGNGGGMKQTNTQISVKDGNGVLRVQIGEITGSW", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more GpJ_HDII-ins2, GpJ_CSF, J_dom that are essential for its biological function; 2. The protein should belong to Viral_Tip_Attach_Protein that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MTIVYDVTGHKGGGGKQHTPQETPDSLHSLAKIRILLALGEGEFEGITSASELRQRVYLDGTPIQNADLSENFPGARVEFRPGTQHQDVIHGFSAVESEQSVGVKLENGTPWVRQINDTSLDAVRVRIGIPALYTSEDNGDLVGGRIDYKIVVYTDNADPREFTFAAVGKTMSLYERDHRIELPPNVNTGWRVEVHRITADSTSAKVVNDIQVQSITEIIDARLRYPLTALLFVEFDAKAFQNIPRVSIKCKGRKVLIPNNYDPINHTYSGDWDGTFKRAWSDNPAWHWYDICITERFGLGRRIKPQMLNRYALYQIAQRCDQLVSDGNGGREIRFKNDMYIQSQTDAWTVLKDLAAIFAGMTWWGNQMLNIVSDQPVAAVSHTITNASVIDGRFDYASGSQKTRYSTFAVAYGNPKNHYDDAIATGQRVELVRRHKINRLDITAIGCTRESEAQRRGHWALISNQLDQQVSFKVGMEGLFFIPGSVVAIADTNISGGFETRGGRLLSDPGTRTVLNTDSEITFRPGDKFLVRTDSGNVETREIASVNGNKVTLKTALDADPIPDQPFCVDGDDIQLQKFRITDLEYDDSTSTFSVRGIEYNDSKYDAVDNGARLDPGIFTQVPDGVMKGPESVTITPSQISSQGQLITNVDIVFPPVKDAVVYEIQWRRTSLQNMAVQWGNDWVNIPRTASNGAHIPNVFSGNYQARVRAIGMGEISSPWVSSAITPVEGRLGGLNAPIITNAISGLHQILWKWNHNNAATDISYTELEVRKTGETEWKFLTNVPYPGAEYAQTSLEFGIYQQLRARVADKIGNLSDWSAPFEGQVSDKVDEYMKGLDDEFLTSEDGKRFQEAIDTVPQGIYEAMLTDAQQLFNARAEYKGIYAEIKVAYNVAADAHKAVAQLETLIGTRLDDAEAAIHTLQTAQSTQEQAFAQYQQTVAAKFSEQEAAIQQVQTATADVAGALAEYKTQVAAQFGQQSAAIEQKMTSSFNHAGGSATYSLKAGVTYNGTYYDAGMQLSVVTEGDAVKSSIAFKADQFYIMHPSNGSLSSAFIVDGGAVYIDTARIKDATINFAQITDTLQSNNYDGDTRGWRLGKDGTFINLGTGNGGGMKQTNTQISVKDGNGVLRVQIGEITGSW" }, { "InterPro": [ { "InterPro-ID": "IPR011339", "InterPro-Name": "ISCU", "InterPro-Type": "FAMILY", "Beg": 39, "End": 159 }, { "InterPro-ID": "IPR002871", "InterPro-Name": "NIF_FeS_clus_asmbl_NifU_N", "InterPro-Type": "DOMAIN", "Beg": 39, "End": 152 }, { "InterPro-ID": "IPR002871", "InterPro-Name": "NIF_FeS_clus_asmbl_NifU_N", "InterPro-Type": "DOMAIN", "Beg": 34, "End": 159 }, { "InterPro-ID": "IPR002871", "InterPro-Name": "NIF_FeS_clus_asmbl_NifU_N", "InterPro-Type": "DOMAIN", "Beg": 39, "End": 160 } ], "response#1": "MKSKILCNLFKGKSCICLYTNCLNENNVNKCYYNLVRNYSDHVKDHFNKPRNVGSFDKNEKNIGTSIVGKASCGDVIKLQLKIENDVIKDARFMAFGCGSAIASSSYATELIKGKTIDEALKIKNNDIASHLSLPPVKIHCSLLAEDAIKHAIKNYREKVLT", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more NIF_FeS_clus_asmbl_NifU_N, NIF_FeS_clus_asmbl_NifU_N, NIF_FeS_clus_asmbl_NifU_N that are essential for its biological function; 2. The protein should belong to ISCU that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MKSKILCNLFKGKSCICLYTNCLNENNVNKCYYNLVRNYSDHVKDHFNKPRNVGSFDKNEKNIGTSIVGKASCGDVIKLQLKIENDVIKDARFMAFGCGSAIASSSYATELIKGKTIDEALKIKNNDIASHLSLPPVKIHCSLLAEDAIKHAIKNYREKVLT" }, { "InterPro": [ { "InterPro-ID": "IPR002223", "InterPro-Name": "Kunitz_BPTI", "InterPro-Type": "DOMAIN", "Beg": 40, "End": 92 }, { "InterPro-ID": "IPR036880", "InterPro-Name": "Kunitz_BPTI_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 97, "End": 153 }, { "InterPro-ID": "IPR036880", "InterPro-Name": "Kunitz_BPTI_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 202, "End": 260 }, { "InterPro-ID": "IPR002223", "InterPro-Name": "Kunitz_BPTI", "InterPro-Type": "DOMAIN", "Beg": 210, "End": 259 }, { "InterPro-ID": "IPR002223", "InterPro-Name": "Kunitz_BPTI", "InterPro-Type": "DOMAIN", "Beg": 40, "End": 93 }, { "InterPro-ID": "IPR002223", "InterPro-Name": "Kunitz_BPTI", "InterPro-Type": "DOMAIN", "Beg": 266, "End": 321 }, { "InterPro-ID": "IPR036880", "InterPro-Name": "Kunitz_BPTI_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 40, "End": 165 }, { "InterPro-ID": "IPR036880", "InterPro-Name": "Kunitz_BPTI_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 34, "End": 96 }, { "InterPro-ID": "IPR002223", "InterPro-Name": "Kunitz_BPTI", "InterPro-Type": "DOMAIN", "Beg": 267, "End": 320 }, { "InterPro-ID": "IPR002223", "InterPro-Name": "Kunitz_BPTI", "InterPro-Type": "DOMAIN", "Beg": 38, "End": 93 }, { "InterPro-ID": "IPR002223", "InterPro-Name": "Kunitz_BPTI", "InterPro-Type": "DOMAIN", "Beg": 208, "End": 260 }, { "InterPro-ID": "IPR002223", "InterPro-Name": "Kunitz_BPTI", "InterPro-Type": "DOMAIN", "Beg": 265, "End": 321 }, { "InterPro-ID": "IPR036880", "InterPro-Name": "Kunitz_BPTI_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 259, "End": 323 }, { "InterPro-ID": "IPR036880", "InterPro-Name": "Kunitz_BPTI_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 205, "End": 263 }, { "InterPro-ID": "IPR050098", "InterPro-Name": "TFPI/VKTCI-like", "InterPro-Type": "FAMILY", "Beg": 241, "End": 321 }, { "InterPro-ID": "IPR036880", "InterPro-Name": "Kunitz_BPTI_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 264, "End": 329 } ], "response#1": "MQRNILWISVVAAFGVFHFGECTYQDSGEDSSSMTEESRCDGPPHASRGLMNIPGWFYDGSRDQCRRYHFPDQQFDMAKNKFKTVTECRKSCRSTVPLQCFKKPPQTIRTMGLPVSTYNSTQGECVTIAVRPGQTGPNIFRREVECNETCRDPEYGKCAPLHIVDCGGSTGNHYNLDKQTCEKTTKNKCGPFATLEDCFKRCARYIQRKCNIPLLKSEYCDIVDLRYWYNSESKQCEEIMGCADDVYNFPTAKECWETCSSKEESRCLQPPDLGKLGIGRTRYYYNITSNRCLTTTHVAFWQNTEKKNNFKRRSDCENTCRPKHKDVKKL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Kunitz_BPTI, Kunitz_BPTI, Kunitz_BPTI, Kunitz_BPTI, Kunitz_BPTI, Kunitz_BPTI, Kunitz_BPTI, Kunitz_BPTI that are essential for its biological function; 2. The protein should belong to TFPI/VKTCI-like that shares evolutionary origin and functional similarity; 3. The protein should be classified within Kunitz_BPTI_sf, Kunitz_BPTI_sf, Kunitz_BPTI_sf, Kunitz_BPTI_sf, Kunitz_BPTI_sf, Kunitz_BPTI_sf, Kunitz_BPTI_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MQRNILWISVVAAFGVFHFGECTYQDSGEDSSSMTEESRCDGPPHASRGLMNIPGWFYDGSRDQCRRYHFPDQQFDMAKNKFKTVTECRKSCRSTVPLQCFKKPPQTIRTMGLPVSTYNSTQGECVTIAVRPGQTGPNIFRREVECNETCRDPEYGKCAPLHIVDCGGSTGNHYNLDKQTCEKTTKNKCGPFATLEDCFKRCARYIQRKCNIPLLKSEYCDIVDLRYWYNSESKQCEEIMGCADDVYNFPTAKECWETCSSKEESRCLQPPDLGKLGIGRTRYYYNITSNRCLTTTHVAFWQNTEKKNNFKRRSDCENTCRPKHKDVKKL" }, { "InterPro": [ { "InterPro-ID": "IPR036278", "InterPro-Name": "Sialidase_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 133, "End": 581 }, { "InterPro-ID": "IPR016285", "InterPro-Name": "Hemagglutn-neuramid", "InterPro-Type": "FAMILY", "Beg": 166, "End": 576 }, { "InterPro-ID": "IPR000665", "InterPro-Name": "Hemagglutn/HN", "InterPro-Type": "FAMILY", "Beg": 37, "End": 581 }, { "InterPro-ID": "IPR016285", "InterPro-Name": "Hemagglutn-neuramid", "InterPro-Type": "FAMILY", "Beg": 1, "End": 582 } ], "response#1": "MEPSKLFIMSDNATFAPGPVVNAAGKKTFRTCFRILVLSVQAVTLILVIVTLGELIRMINDQGLSNQLSSITDKIRESAAMIASAVGVMNQVIHGVTVSLPLQIEGNQNQLLSTLATICTNRNQVSNCSTNIPLVNDLRFINGINKFIIEDYATHDFSIGHPLNMPSFIPTATSPNGCTRIPSFSLGKTHWCYTHNVINANCKDHTSSNQYVSMGILVQTASGYPMFKTLKIQYLSDGLNRKSCSIATVPDGCAMYCYVSTQLETDDYAGSSPPTQKLTLLFYNDTIKERTISPSGLEGNWATLVPGVGSGIYFENKLIFPAYGGVLPNSTLGVKSAREFFRPVNPYNPCSGPPQELDQRALRSYFPSYFSSRRVQSAFLVCAWNQILVTNCELVVPSNNQTLMGAEGRVLLINNRLLYYQRSTSWWPYELLYEISFTFTNSGQSSVNMSWIPIYSFTRPGLGKCSGENICPTVCVSGVYLDPWPLTPYSHQSGINRNFYFTGALLNSSTTRVNPTLYVSALNNLKVLAPYGTQGLFASYTTTTCFQDTGDASVYCVYIMELASNIVGEFQILPVLARLTIT", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Hemagglutn-neuramid, Hemagglutn/HN, Hemagglutn-neuramid that shares evolutionary origin and functional similarity; 2. The protein should be classified within Sialidase_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MEPSKLFIMSDNATFAPGPVVNAAGKKTFRTCFRILVLSVQAVTLILVIVTLGELIRMINDQGLSNQLSSITDKIRESAAMIASAVGVMNQVIHGVTVSLPLQIEGNQNQLLSTLATICTNRNQVSNCSTNIPLVNDLRFINGINKFIIEDYATHDFSIGHPLNMPSFIPTATSPNGCTRIPSFSLGKTHWCYTHNVINANCKDHTSSNQYVSMGILVQTASGYPMFKTLKIQYLSDGLNRKSCSIATVPDGCAMYCYVSTQLETDDYAGSSPPTQKLTLLFYNDTIKERTISPSGLEGNWATLVPGVGSGIYFENKLIFPAYGGVLPNSTLGVKSAREFFRPVNPYNPCSGPPQELDQRALRSYFPSYFSSRRVQSAFLVCAWNQILVTNCELVVPSNNQTLMGAEGRVLLINNRLLYYQRSTSWWPYELLYEISFTFTNSGQSSVNMSWIPIYSFTRPGLGKCSGENICPTVCVSGVYLDPWPLTPYSHQSGINRNFYFTGALLNSSTTRVNPTLYVSALNNLKVLAPYGTQGLFASYTTTTCFQDTGDASVYCVYIMELASNIVGEFQILPVLARLTIT" }, { "InterPro": [ { "InterPro-ID": "IPR010982", "InterPro-Name": "Lambda_DNA-bd_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 5, "End": 68 }, { "InterPro-ID": "IPR046335", "InterPro-Name": "LacI/GalR-like_sensor", "InterPro-Type": "DOMAIN", "Beg": 183, "End": 340 }, { "InterPro-ID": "IPR010982", "InterPro-Name": "Lambda_DNA-bd_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 9, "End": 68 }, { "InterPro-ID": "IPR000843", "InterPro-Name": "HTH_LacI", "InterPro-Type": "DOMAIN", "Beg": 16, "End": 66 }, { "InterPro-ID": "IPR000843", "InterPro-Name": "HTH_LacI", "InterPro-Type": "DOMAIN", "Beg": 10, "End": 81 }, { "InterPro-ID": "IPR000843", "InterPro-Name": "HTH_LacI", "InterPro-Type": "DOMAIN", "Beg": 11, "End": 66 }, { "InterPro-ID": "IPR028082", "InterPro-Name": "Peripla_BP_I", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 72, "End": 340 } ], "response#1": "MPRSPHPPRRATLASLAAELKVSRTTISNAYNRPDQLSADLRERIFDAAKRLGYPGPDPVARSLRTRKAGAVGLMITEPLDYSFSDPAALDFVAGLAESCEEAGQGLLLVAVGPNRTFEEGSNSVLAAGVDGFVVYSASDDDPYLPVLQQRQLPMVVVDQPKDVPGVSRISIDDRGAMRELAEYVLELGHRDIGLLTMRLGRDWPHGDPRPALADPERVLSPHFHVQRERIHGVYDAMSAAGLDPSSLTVVESYEHLPTSGGAAAEVALEVNPRITALMCTADVLALSAMDHLRSRGIYVPGHMTVTGFDGVRDALRRGLTTVKQPSMEKGRRAGHLLHNPPGSGLPVIDVLETEVVRGRTSGPPA", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more LacI/GalR-like_sensor, HTH_LacI, HTH_LacI, HTH_LacI that are essential for its biological function; 2. The protein should be classified within Lambda_DNA-bd_dom_sf, Lambda_DNA-bd_dom_sf, Peripla_BP_I sharing conserved structural features. The designed protein sequence is ", "reference": "MPRSPHPPRRATLASLAAELKVSRTTISNAYNRPDQLSADLRERIFDAAKRLGYPGPDPVARSLRTRKAGAVGLMITEPLDYSFSDPAALDFVAGLAESCEEAGQGLLLVAVGPNRTFEEGSNSVLAAGVDGFVVYSASDDDPYLPVLQQRQLPMVVVDQPKDVPGVSRISIDDRGAMRELAEYVLELGHRDIGLLTMRLGRDWPHGDPRPALADPERVLSPHFHVQRERIHGVYDAMSAAGLDPSSLTVVESYEHLPTSGGAAAEVALEVNPRITALMCTADVLALSAMDHLRSRGIYVPGHMTVTGFDGVRDALRRGLTTVKQPSMEKGRRAGHLLHNPPGSGLPVIDVLETEVVRGRTSGPPA" }, { "InterPro": [ { "InterPro-ID": "IPR023355", "InterPro-Name": "Myo_ane_neurotoxin_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1, "End": 41 }, { "InterPro-ID": "IPR012414", "InterPro-Name": "BDS_K_chnl_tox", "InterPro-Type": "FAMILY", "Beg": 2, "End": 35 } ], "response#1": "GTPCDCYGYTGVYWFMLSRCPSGYGYNLSCHYFMGICCVKR", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to BDS_K_chnl_tox that shares evolutionary origin and functional similarity; 2. The protein should be classified within Myo_ane_neurotoxin_sf sharing conserved structural features. The designed protein sequence is ", "reference": "GTPCDCYGYTGVYWFMLSRCPSGYGYNLSCHYFMGICCVKR" }, { "InterPro": [ { "InterPro-ID": "IPR003582", "InterPro-Name": "ShKT_dom", "InterPro-Type": "DOMAIN", "Beg": 2, "End": 36 } ], "response#1": "ACENNFSDRECERRKKDCDSSMKFRELSCPKTCGTC", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more ShKT_dom that are essential for its biological function. The designed protein sequence is ", "reference": "ACENNFSDRECERRKKDCDSSMKFRELSCPKTCGTC" }, { "InterPro": [ { "InterPro-ID": "IPR024279", "InterPro-Name": "Paramyx_V_Zn-bd", "InterPro-Type": "DOMAIN", "Beg": 175, "End": 218 } ], "response#1": "MDQFIKQDETGDLIETGMNVANHFLSAPIQGTNSLSKASIIPGVAPVLIGNPEQKNIQHPTASHQGSKSKGRGSGVRSITVPPPEAGNGGTQIPEPLFAQTGQGGIVTTVHQDPTIQPTGSYRSVELAKIGKERMINRFVEKPRTSTPVTEFKRGAGSGCSRPDNPRGGHRREWSLSWVQGEVRVFEWCNPICSPITAAARFHSCKCGNCPAKCDQCERDYGPP", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Paramyx_V_Zn-bd that are essential for its biological function. The designed protein sequence is ", "reference": "MDQFIKQDETGDLIETGMNVANHFLSAPIQGTNSLSKASIIPGVAPVLIGNPEQKNIQHPTASHQGSKSKGRGSGVRSITVPPPEAGNGGTQIPEPLFAQTGQGGIVTTVHQDPTIQPTGSYRSVELAKIGKERMINRFVEKPRTSTPVTEFKRGAGSGCSRPDNPRGGHRREWSLSWVQGEVRVFEWCNPICSPITAAARFHSCKCGNCPAKCDQCERDYGPP" }, { "InterPro": [ { "InterPro-ID": "IPR029033", "InterPro-Name": "His_PPase_superfam", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 22, "End": 378 }, { "InterPro-ID": "IPR000560", "InterPro-Name": "His_Pase_clade-2", "InterPro-Type": "FAMILY", "Beg": 54, "End": 330 }, { "InterPro-ID": "IPR029033", "InterPro-Name": "His_PPase_superfam", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 22, "End": 375 } ], "response#1": "MKATILLFLVLAVVQLSTAAEQLKFVFVTVRGADYEVCDIPGGPKITNKDGKDSKLTEEGKNTVYQLGVKVSELYKSKLGVSKWDSSKNYWPIATNSRRSQISTLITGAGLEGDQSKRDKSWTDEELKKTSFPAMLQFWKFIDPAKCPKFFKEVSQQPEIATTLQDCASQMQEVKKHYDTVDPTKPQHVWLTYETLKKMKKQQPSKVEWASDDMMKKLRECSAKLNWLATTKTDTLRKLSGGLILSDILNDMKEITQGKAQPHATGGTSNKLSLFTTPQGLLIAKLAVFMPPGATLDGKVPTSSEVYPESGATMNTEMYEDNGTWKVKLIYYEGKDYPGKTIKLPGCEEKCPFQQFQQILTKYAVNEQEHETLCKSAQWP", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to His_Pase_clade-2 that shares evolutionary origin and functional similarity; 2. The protein should be classified within His_PPase_superfam, His_PPase_superfam sharing conserved structural features. The designed protein sequence is ", "reference": "MKATILLFLVLAVVQLSTAAEQLKFVFVTVRGADYEVCDIPGGPKITNKDGKDSKLTEEGKNTVYQLGVKVSELYKSKLGVSKWDSSKNYWPIATNSRRSQISTLITGAGLEGDQSKRDKSWTDEELKKTSFPAMLQFWKFIDPAKCPKFFKEVSQQPEIATTLQDCASQMQEVKKHYDTVDPTKPQHVWLTYETLKKMKKQQPSKVEWASDDMMKKLRECSAKLNWLATTKTDTLRKLSGGLILSDILNDMKEITQGKAQPHATGGTSNKLSLFTTPQGLLIAKLAVFMPPGATLDGKVPTSSEVYPESGATMNTEMYEDNGTWKVKLIYYEGKDYPGKTIKLPGCEEKCPFQQFQQILTKYAVNEQEHETLCKSAQWP" }, { "InterPro": [ { "InterPro-ID": "IPR029033", "InterPro-Name": "His_PPase_superfam", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 29, "End": 377 }, { "InterPro-ID": "IPR029033", "InterPro-Name": "His_PPase_superfam", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 45, "End": 374 } ], "response#1": "MKTTILLLVVLTIVQLSKAKDNLQFVFVTAKGQDHQACNYPQGPKITNIEEPDSELTEDGKKEAYEFGQKLSSEYKSRLGVTKWDSAQNYWAIAAIEKRTKKATLITAGVIAKRQSVTSKTWSDEELQKTSFPALNDFFRFINPQHCPKYIKSILSKQNDINTILGKCEAALKTVKEHYPAVNKPQHTWLVYETFKRMKQQKASNLEWLTDDIMKQLQACSAEITWFAATNSDEWRKISGGLLLTDIFTDLDQITQGKPQPYAPGGANNKMSLFTVPQVLVISHLAVITPPGTKIGSKDVTAQNIYPEDGAYVNLELFKGDKEDWKVKIVYVKGKGEPQQTIALPGCPEKCPYNKFKQILQQYAISDDDHKKACGFPA", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should be classified within His_PPase_superfam, His_PPase_superfam sharing conserved structural features. The designed protein sequence is ", "reference": "MKTTILLLVVLTIVQLSKAKDNLQFVFVTAKGQDHQACNYPQGPKITNIEEPDSELTEDGKKEAYEFGQKLSSEYKSRLGVTKWDSAQNYWAIAAIEKRTKKATLITAGVIAKRQSVTSKTWSDEELQKTSFPALNDFFRFINPQHCPKYIKSILSKQNDINTILGKCEAALKTVKEHYPAVNKPQHTWLVYETFKRMKQQKASNLEWLTDDIMKQLQACSAEITWFAATNSDEWRKISGGLLLTDIFTDLDQITQGKPQPYAPGGANNKMSLFTVPQVLVISHLAVITPPGTKIGSKDVTAQNIYPEDGAYVNLELFKGDKEDWKVKIVYVKGKGEPQQTIALPGCPEKCPYNKFKQILQQYAISDDDHKKACGFPA" }, { "InterPro": [ { "InterPro-ID": "IPR050121", "InterPro-Name": "Cytochrome_P450_monoxygenase", "InterPro-Type": "FAMILY", "Beg": 3, "End": 457 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 72, "End": 454 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 431, "End": 440 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 440, "End": 451 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 304, "End": 321 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 347, "End": 358 }, { "InterPro-ID": "IPR017972", "InterPro-Name": "Cyt_P450_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 433, "End": 442 }, { "InterPro-ID": "IPR036396", "InterPro-Name": "Cyt_P450_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 19, "End": 456 }, { "InterPro-ID": "IPR002403", "InterPro-Name": "Cyt_P450_E_grp-IV", "InterPro-Type": "FAMILY", "Beg": 395, "End": 413 }, { "InterPro-ID": "IPR002403", "InterPro-Name": "Cyt_P450_E_grp-IV", "InterPro-Type": "FAMILY", "Beg": 424, "End": 440 }, { "InterPro-ID": "IPR002403", "InterPro-Name": "Cyt_P450_E_grp-IV", "InterPro-Type": "FAMILY", "Beg": 295, "End": 321 }, { "InterPro-ID": "IPR002403", "InterPro-Name": "Cyt_P450_E_grp-IV", "InterPro-Type": "FAMILY", "Beg": 440, "End": 458 }, { "InterPro-ID": "IPR036396", "InterPro-Name": "Cyt_P450_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 17, "End": 467 } ], "response#1": "MWSLIPLTAIVLVLVAILHRLFFHPLSHVPGPFLARFSSLYLHSICYLGIEATVLRQLHIKYKTKVLRVAPNSVSISDSEAVGEIYVRGGGFPKDDRYKNFNLGPIVSIFSSLDREYRDVRAKAVAPLFSPAQLRAESGPQGVIGGCIAEFVDQLRKSKEAGIGADLMDMCARLSIDVVTGYLLGQKYGGLQENAHLPPQERQSHKLSANPFIFSIVAFSRFSLLPHRIFQFLYSTSQRLSTNDEVTESFLKLDRFTNNVLEGTTAGEKVSEKPNGGYYHERLISQAGISRMEAAAQSQAVLFAGADSTAVMLATILFHLVQNGAARSRLLCEVRSDKPQDMRFLRAVVKEGLRLGMANPTRMTRVVPKSGPGLRVGDVLLSPGTIVGCAAYNLHHDPEVFPDPFTFRPERWLDDGTDRGLRRPGMEKSMIPFGVGSRACIGKNLAQQQLHDTVVAVIDSEVLEGARTCQERIEIIEWFNADIKGHHLDIKWS", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Cytochrome_P450_monoxygenase, Cyt_P450, Cyt_P450, Cyt_P450, Cyt_P450, Cyt_P450, Cyt_P450_E_grp-IV, Cyt_P450_E_grp-IV, Cyt_P450_E_grp-IV, Cyt_P450_E_grp-IV that shares evolutionary origin and functional similarity; 2. The protein should be classified within Cyt_P450_sf, Cyt_P450_sf sharing conserved structural features; 3. The protein should contain Cyt_P450_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MWSLIPLTAIVLVLVAILHRLFFHPLSHVPGPFLARFSSLYLHSICYLGIEATVLRQLHIKYKTKVLRVAPNSVSISDSEAVGEIYVRGGGFPKDDRYKNFNLGPIVSIFSSLDREYRDVRAKAVAPLFSPAQLRAESGPQGVIGGCIAEFVDQLRKSKEAGIGADLMDMCARLSIDVVTGYLLGQKYGGLQENAHLPPQERQSHKLSANPFIFSIVAFSRFSLLPHRIFQFLYSTSQRLSTNDEVTESFLKLDRFTNNVLEGTTAGEKVSEKPNGGYYHERLISQAGISRMEAAAQSQAVLFAGADSTAVMLATILFHLVQNGAARSRLLCEVRSDKPQDMRFLRAVVKEGLRLGMANPTRMTRVVPKSGPGLRVGDVLLSPGTIVGCAAYNLHHDPEVFPDPFTFRPERWLDDGTDRGLRRPGMEKSMIPFGVGSRACIGKNLAQQQLHDTVVAVIDSEVLEGARTCQERIEIIEWFNADIKGHHLDIKWS" }, { "InterPro": [ { "InterPro-ID": "IPR001077", "InterPro-Name": "O_MeTrfase_dom", "InterPro-Type": "DOMAIN", "Beg": 225, "End": 380 }, { "InterPro-ID": "IPR029063", "InterPro-Name": "SAM-dependent_MTases_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 149, "End": 398 }, { "InterPro-ID": "IPR029063", "InterPro-Name": "SAM-dependent_MTases_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 143, "End": 396 }, { "InterPro-ID": "IPR036388", "InterPro-Name": "WH-like_DNA-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 58, "End": 136 }, { "InterPro-ID": "IPR016461", "InterPro-Name": "COMT-like", "InterPro-Type": "FAMILY", "Beg": 60, "End": 399 }, { "InterPro-ID": "IPR036390", "InterPro-Name": "WH_DNA-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 57, "End": 140 }, { "InterPro-ID": "IPR012967", "InterPro-Name": "Plant_O-MeTrfase_dimerisation", "InterPro-Type": "DOMAIN", "Beg": 70, "End": 138 } ], "response#1": "MASTTNGVNGHKASQPQSLIQTLNNIGADSFSNDGERIQAVLAAYALVSRLETPWEFVARTCMGQPALGAALKVAKDLKLYDKWHELGDGEMTCEQLSELVSCDSALLFRILRHLAANHVLEETSIGVFKPTKLSISFTVPVFGEWINHLYDATTPCFFKMPEFLAQNGYKNPVDPNNGVFQAAKGWKGDMFDYYKSHPVEGASFDHVMGGVMANQAGWLEIFPHNKLLETADAQSPLVVDVGGNIGHDIERFRQEHPETASRLYLEDLPEVVKRSKCPDDVNKVGYDFFTPQPIKGARAYYMHGVLHDWSEEPARKILEMQKEAMKPGYSTLLIHDHIAPESLAHPHTTAYDLTMMVMVAGVERREAHWRALLKSAGYKLVRIWRSPLAVQGVIEAELDQ", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more O_MeTrfase_dom, Plant_O-MeTrfase_dimerisation that are essential for its biological function; 2. The protein should belong to COMT-like that shares evolutionary origin and functional similarity; 3. The protein should be classified within SAM-dependent_MTases_sf, SAM-dependent_MTases_sf, WH-like_DNA-bd_sf, WH_DNA-bd_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MASTTNGVNGHKASQPQSLIQTLNNIGADSFSNDGERIQAVLAAYALVSRLETPWEFVARTCMGQPALGAALKVAKDLKLYDKWHELGDGEMTCEQLSELVSCDSALLFRILRHLAANHVLEETSIGVFKPTKLSISFTVPVFGEWINHLYDATTPCFFKMPEFLAQNGYKNPVDPNNGVFQAAKGWKGDMFDYYKSHPVEGASFDHVMGGVMANQAGWLEIFPHNKLLETADAQSPLVVDVGGNIGHDIERFRQEHPETASRLYLEDLPEVVKRSKCPDDVNKVGYDFFTPQPIKGARAYYMHGVLHDWSEEPARKILEMQKEAMKPGYSTLLIHDHIAPESLAHPHTTAYDLTMMVMVAGVERREAHWRALLKSAGYKLVRIWRSPLAVQGVIEAELDQ" }, { "InterPro": [ { "InterPro-ID": "IPR017795", "InterPro-Name": "Aro_prenylTrfase_DMATS", "InterPro-Type": "FAMILY", "Beg": 27, "End": 391 }, { "InterPro-ID": "IPR017795", "InterPro-Name": "Aro_prenylTrfase_DMATS", "InterPro-Type": "FAMILY", "Beg": 25, "End": 436 }, { "InterPro-ID": "IPR033964", "InterPro-Name": "Aro_prenylTrfase", "InterPro-Type": "FAMILY", "Beg": 24, "End": 439 }, { "InterPro-ID": "IPR017795", "InterPro-Name": "Aro_prenylTrfase_DMATS", "InterPro-Type": "FAMILY", "Beg": 23, "End": 432 }, { "InterPro-ID": "IPR017795", "InterPro-Name": "Aro_prenylTrfase_DMATS", "InterPro-Type": "FAMILY", "Beg": 30, "End": 435 } ], "response#1": "MTAAVQSPVLPLLEKENVADIAIPEGDSTYWWRTSGQDLSRMLQEAGYPDEAKRQFLNYFRDTICPTLGGKPDSNALRTAVGWDGSPFEYSFEFKESTKSAGVRFVVDLTQLRPGDKSAPLTTKTTENVIESLSKKTPLFDDNWHRALSQWFVYSHAPESEQKALVAAAGYQTNIIMGFDINAKILDLAPGYLPIMAKSYFPPCFVAEAKGFTRWQALSLGIRQIPDIGSHPNILLALKLIEDYVAAKPELAGGARGLSTDFVKAGKARLKIYMRYLGDDFEEVWDYYTLGGKIPDLESDKEMFRDLMTLSSPSTYTEEDWKDTQVDPRRRAAFKTKPTAVYFSLSPDKPYPIPKVYFYPARAAPNDKVIARGLDAWLTKYNWHDGGKSVEERVESVFTHRKLEENPGIFTFIGLGRKEDSTKKGLSLQVYMTPELYVTPRF", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Aro_prenylTrfase_DMATS, Aro_prenylTrfase_DMATS, Aro_prenylTrfase, Aro_prenylTrfase_DMATS, Aro_prenylTrfase_DMATS that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MTAAVQSPVLPLLEKENVADIAIPEGDSTYWWRTSGQDLSRMLQEAGYPDEAKRQFLNYFRDTICPTLGGKPDSNALRTAVGWDGSPFEYSFEFKESTKSAGVRFVVDLTQLRPGDKSAPLTTKTTENVIESLSKKTPLFDDNWHRALSQWFVYSHAPESEQKALVAAAGYQTNIIMGFDINAKILDLAPGYLPIMAKSYFPPCFVAEAKGFTRWQALSLGIRQIPDIGSHPNILLALKLIEDYVAAKPELAGGARGLSTDFVKAGKARLKIYMRYLGDDFEEVWDYYTLGGKIPDLESDKEMFRDLMTLSSPSTYTEEDWKDTQVDPRRRAAFKTKPTAVYFSLSPDKPYPIPKVYFYPARAAPNDKVIARGLDAWLTKYNWHDGGKSVEERVESVFTHRKLEENPGIFTFIGLGRKEDSTKKGLSLQVYMTPELYVTPRF" }, { "InterPro": [ { "InterPro-ID": "IPR046335", "InterPro-Name": "LacI/GalR-like_sensor", "InterPro-Type": "DOMAIN", "Beg": 182, "End": 333 }, { "InterPro-ID": "IPR000843", "InterPro-Name": "HTH_LacI", "InterPro-Type": "DOMAIN", "Beg": 9, "End": 64 }, { "InterPro-ID": "IPR000843", "InterPro-Name": "HTH_LacI", "InterPro-Type": "DOMAIN", "Beg": 8, "End": 79 }, { "InterPro-ID": "IPR028082", "InterPro-Name": "Peripla_BP_I", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 70, "End": 334 }, { "InterPro-ID": "IPR000843", "InterPro-Name": "HTH_LacI", "InterPro-Type": "DOMAIN", "Beg": 14, "End": 64 }, { "InterPro-ID": "IPR010982", "InterPro-Name": "Lambda_DNA-bd_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 7, "End": 66 }, { "InterPro-ID": "IPR010982", "InterPro-Name": "Lambda_DNA-bd_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1, "End": 66 } ], "response#1": "MSPTPRRRATLASLAAELKVSRTTVSNAFNRPDQLSADLRERVLATAKRLGYAGPDPVARSLRTRKAGAVGLVMAEPLTYFFSDPAARDFVAGVAQSCEELGQGLQLVSVGSSRSLADGTAAVLGAGVDGFVVYSVGDDDPYLQVVLQRRLPVVVVDQPKDLSGVSRVGIDDRAAMRELAGYVLGLGHRELGLLTMRLGRDRRQDLVDAERLRSPTFDVQRERIVGVWEAMTAAGVDPDSLTVVESYEHLPTSGGTAAKVALQANPRLTALMCTADILALSAMDYLRAHGIYVPGQMTVTGFDGVPEALSRGLTTVAQPSLHKGHRAGELLLKPPRSGLPVIEVLDTELVRGRTAGPPA", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more LacI/GalR-like_sensor, HTH_LacI, HTH_LacI, HTH_LacI that are essential for its biological function; 2. The protein should be classified within Peripla_BP_I, Lambda_DNA-bd_dom_sf, Lambda_DNA-bd_dom_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MSPTPRRRATLASLAAELKVSRTTVSNAFNRPDQLSADLRERVLATAKRLGYAGPDPVARSLRTRKAGAVGLVMAEPLTYFFSDPAARDFVAGVAQSCEELGQGLQLVSVGSSRSLADGTAAVLGAGVDGFVVYSVGDDDPYLQVVLQRRLPVVVVDQPKDLSGVSRVGIDDRAAMRELAGYVLGLGHRELGLLTMRLGRDRRQDLVDAERLRSPTFDVQRERIVGVWEAMTAAGVDPDSLTVVESYEHLPTSGGTAAKVALQANPRLTALMCTADILALSAMDYLRAHGIYVPGQMTVTGFDGVPEALSRGLTTVAQPSLHKGHRAGELLLKPPRSGLPVIEVLDTELVRGRTAGPPA" }, { "InterPro": [ { "InterPro-ID": "IPR034593", "InterPro-Name": "DgoD-like", "InterPro-Type": "FAMILY", "Beg": 3, "End": 292 }, { "InterPro-ID": "IPR013341", "InterPro-Name": "Mandelate_racemase_N_dom", "InterPro-Type": "DOMAIN", "Beg": 8, "End": 85 }, { "InterPro-ID": "IPR013342", "InterPro-Name": "Mandelate_racemase_C", "InterPro-Type": "DOMAIN", "Beg": 103, "End": 194 }, { "InterPro-ID": "IPR029017", "InterPro-Name": "Enolase-like_N", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 2, "End": 85 }, { "InterPro-ID": "IPR029065", "InterPro-Name": "Enolase_C-like", "InterPro-Type": "DOMAIN", "Beg": 119, "End": 261 }, { "InterPro-ID": "IPR034603", "InterPro-Name": "Dipeptide_epimerase", "InterPro-Type": "FAMILY", "Beg": 2, "End": 274 }, { "InterPro-ID": "IPR029017", "InterPro-Name": "Enolase-like_N", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1, "End": 77 }, { "InterPro-ID": "IPR018110", "InterPro-Name": "Mandel_Rmase/mucon_lact_enz_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 144, "End": 175 }, { "InterPro-ID": "IPR036849", "InterPro-Name": "Enolase-like_C_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 94, "End": 299 }, { "InterPro-ID": "IPR036849", "InterPro-Name": "Enolase-like_C_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 91, "End": 291 }, { "InterPro-ID": "IPR034603", "InterPro-Name": "Dipeptide_epimerase", "InterPro-Type": "FAMILY", "Beg": 2, "End": 299 } ], "response#1": "MIVVVIADKEFYGWAESVPYARYDESISTSTKQIKALFCDRSFTRKMELSELINTLPAGAARNALDCAMWDLQAKQSTRPVAEILSKTSITSICAHTLSIDTPKAMQEAVLAMNSPPLVKVKLDKQDIIARMTAIANAAPHSQFIVDANEDWCFRDLEENVEALKALNVVLIEQPLPAGEDEQLINFTSPIPLCADESCHTENDLPYLQGRYQVVNIKLDKTGGLTQACSLASKAQKMGFDIMLGCMVGSSLAMAPASLLASQARYVDLDGPLLVLKDRKHHFTYADGQMSPLQSCLWGGAHNSERFFVDRLQLQ", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Mandelate_racemase_N_dom, Mandelate_racemase_C, Enolase_C-like that are essential for its biological function; 2. The protein should belong to DgoD-like, Dipeptide_epimerase, Dipeptide_epimerase that shares evolutionary origin and functional similarity; 3. The protein should be classified within Enolase-like_N, Enolase-like_N, Enolase-like_C_sf, Enolase-like_C_sf sharing conserved structural features; 4. The protein should contain Mandel_Rmase/mucon_lact_enz_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MIVVVIADKEFYGWAESVPYARYDESISTSTKQIKALFCDRSFTRKMELSELINTLPAGAARNALDCAMWDLQAKQSTRPVAEILSKTSITSICAHTLSIDTPKAMQEAVLAMNSPPLVKVKLDKQDIIARMTAIANAAPHSQFIVDANEDWCFRDLEENVEALKALNVVLIEQPLPAGEDEQLINFTSPIPLCADESCHTENDLPYLQGRYQVVNIKLDKTGGLTQACSLASKAQKMGFDIMLGCMVGSSLAMAPASLLASQARYVDLDGPLLVLKDRKHHFTYADGQMSPLQSCLWGGAHNSERFFVDRLQLQ" }, { "InterPro": [ { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 127, "End": 332 }, { "InterPro-ID": "IPR035402", "InterPro-Name": "DgcN-like_N", "InterPro-Type": "DOMAIN", "Beg": 42, "End": 125 }, { "InterPro-ID": "IPR035086", "InterPro-Name": "DgcN-like_C", "InterPro-Type": "DOMAIN", "Beg": 129, "End": 328 }, { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1, "End": 330 }, { "InterPro-ID": "IPR011669", "InterPro-Name": "DgcN-like", "InterPro-Type": "FAMILY", "Beg": 3, "End": 331 }, { "InterPro-ID": "IPR011669", "InterPro-Name": "DgcN-like", "InterPro-Type": "FAMILY", "Beg": 53, "End": 329 } ], "response#1": "MQIKPPYLLFIGDATDKLSIKMAQSLADWRAELCVGELSVNGCTVSTGLNQCSICEAAKLGAKTFVLGFANSGGVLDKKWLPIISEAIENGMNIVSGLHDKLTNFDELVSLSQKHNTNLLDIRHPSTAFATGKGYKRKGKRLLTVGTDCSVGKMYTSLSLEKAMKEQNIDVDFRATGQCGILISGSGVAIDCVIADFISGAAESLSPDAEETHWDIIEGQGSLSHPAFAGVSLGLLHGSQPDALVICHALNRTHMRGLLHTSFPSIETTIELNIAAAKLTNPDVQVVGISVNTSSVSIEQGNEICERLSQTFGVPCVDPLRDGVDSIVANLC", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more DgcN-like_N, DgcN-like_C that are essential for its biological function; 2. The protein should belong to DgcN-like, DgcN-like that shares evolutionary origin and functional similarity; 3. The protein should be classified within P-loop_NTPase, P-loop_NTPase sharing conserved structural features. The designed protein sequence is ", "reference": "MQIKPPYLLFIGDATDKLSIKMAQSLADWRAELCVGELSVNGCTVSTGLNQCSICEAAKLGAKTFVLGFANSGGVLDKKWLPIISEAIENGMNIVSGLHDKLTNFDELVSLSQKHNTNLLDIRHPSTAFATGKGYKRKGKRLLTVGTDCSVGKMYTSLSLEKAMKEQNIDVDFRATGQCGILISGSGVAIDCVIADFISGAAESLSPDAEETHWDIIEGQGSLSHPAFAGVSLGLLHGSQPDALVICHALNRTHMRGLLHTSFPSIETTIELNIAAAKLTNPDVQVVGISVNTSSVSIEQGNEICERLSQTFGVPCVDPLRDGVDSIVANLC" }, { "InterPro": [ { "InterPro-ID": "IPR036291", "InterPro-Name": "NAD(P)-bd_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 162, "End": 356 }, { "InterPro-ID": "IPR014184", "InterPro-Name": "HCHO_DH_non_GSH", "InterPro-Type": "FAMILY", "Beg": 2, "End": 395 }, { "InterPro-ID": "IPR011032", "InterPro-Name": "GroES-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 4, "End": 187 }, { "InterPro-ID": "IPR002328", "InterPro-Name": "ADH_Zn_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 67, "End": 81 }, { "InterPro-ID": "IPR013154", "InterPro-Name": "ADH-like_N", "InterPro-Type": "DOMAIN", "Beg": 35, "End": 153 }, { "InterPro-ID": "IPR013149", "InterPro-Name": "ADH-like_C", "InterPro-Type": "DOMAIN", "Beg": 197, "End": 264 } ], "response#1": "MSGNRGVVYLGPGKVEVQNIPYPKMQDPQGRQIDHGVILRVVSTNICGSDQHMVRGRTTAPEGLVLGHEITGEVVEIGRGVETMKIGDLVSVPFNVACGHCRTCKEQHTGVCLTVNPARAGGAYGYVDMGGWVGGQAEYVLVPYADFNLLKLPNREAAMEKIRDLTCLSDILPTGYHGAVTAGVGPGSTVYIAGAGPVGLAAAASARLLGAAVVIVGDVNPTRLAHAKKQGFEIADLSKDTPLHEQIAALLGEPEVDCAVDAVGFEARGHGHSGSQQEAPATVLNSLMGITRVAGKIGIPGLYVTEDPGAVDAAAKHGALSIRFGLGWAKSHSFHTGQTPVMKYNRQLMQAIMWDRIKIADIVGVEVITLDDAPKGYGEFDAGVPKKFVIDPHNLFRAA", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more ADH-like_N, ADH-like_C that are essential for its biological function; 2. The protein should belong to HCHO_DH_non_GSH that shares evolutionary origin and functional similarity; 3. The protein should be classified within NAD(P)-bd_dom_sf, GroES-like_sf sharing conserved structural features; 4. The protein should contain ADH_Zn_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MSGNRGVVYLGPGKVEVQNIPYPKMQDPQGRQIDHGVILRVVSTNICGSDQHMVRGRTTAPEGLVLGHEITGEVVEIGRGVETMKIGDLVSVPFNVACGHCRTCKEQHTGVCLTVNPARAGGAYGYVDMGGWVGGQAEYVLVPYADFNLLKLPNREAAMEKIRDLTCLSDILPTGYHGAVTAGVGPGSTVYIAGAGPVGLAAAASARLLGAAVVIVGDVNPTRLAHAKKQGFEIADLSKDTPLHEQIAALLGEPEVDCAVDAVGFEARGHGHSGSQQEAPATVLNSLMGITRVAGKIGIPGLYVTEDPGAVDAAAKHGALSIRFGLGWAKSHSFHTGQTPVMKYNRQLMQAIMWDRIKIADIVGVEVITLDDAPKGYGEFDAGVPKKFVIDPHNLFRAA" }, { "InterPro": [ { "InterPro-ID": "IPR054446", "InterPro-Name": "CIMIP3-like", "InterPro-Type": "FAMILY", "Beg": 118, "End": 192 } ], "response#1": "MLLAEEFAESALHRRVLFHAAAGRAGAEGGPSLPRLPCSGLDSAPSPRGPLPGHAPRRPPRPRTGRQVLGAPPLSEKCELPGQDSQKSSVPSHGPKTPSGQKVKAPHRPLSLSWKQDREQTLAAAYVPVVVDPRGQNPEKLRFNFYTSQYSNSLNPFYTLQKPTCGYLYRRDTDHTRKRFDVPPANLVLWRS", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to CIMIP3-like that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MLLAEEFAESALHRRVLFHAAAGRAGAEGGPSLPRLPCSGLDSAPSPRGPLPGHAPRRPPRPRTGRQVLGAPPLSEKCELPGQDSQKSSVPSHGPKTPSGQKVKAPHRPLSLSWKQDREQTLAAAYVPVVVDPRGQNPEKLRFNFYTSQYSNSLNPFYTLQKPTCGYLYRRDTDHTRKRFDVPPANLVLWRS" }, { "InterPro": [ { "InterPro-ID": "IPR005259", "InterPro-Name": "PriA", "InterPro-Type": "FAMILY", "Beg": 34, "End": 925 }, { "InterPro-ID": "IPR041222", "InterPro-Name": "PriA_3primeBD", "InterPro-Type": "DOMAIN", "Beg": 34, "End": 126 }, { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 408, "End": 569 }, { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 435, "End": 527 }, { "InterPro-ID": "IPR040498", "InterPro-Name": "PriA_CRR", "InterPro-Type": "DOMAIN", "Beg": 654, "End": 679 }, { "InterPro-ID": "IPR050880", "InterPro-Name": "PriA_helicase", "InterPro-Type": "FAMILY", "Beg": 33, "End": 924 }, { "InterPro-ID": "IPR041236", "InterPro-Name": "PriA_C", "InterPro-Type": "DOMAIN", "Beg": 833, "End": 922 }, { "InterPro-ID": "IPR005259", "InterPro-Name": "PriA", "InterPro-Type": "FAMILY", "Beg": 438, "End": 922 } ], "response#1": "MTLWTVSPPAVSSEAEEKPVQDTVSLTAADQTWQVCVPLPIAALDFAAPHGYVGEVPLGCRVAVPWRGGEIRVGLVVGAGSSMGRHRLREALALLDSPEAPWVAPGTARGLTAWAEEAHLPPGLVWDDLLCTGWEPAHRHEVRAVPGADLSPYGETLPDTDWSRADLYPPALLDAAREQGLLDDRFLPDPPQVNRVVARDLNDVPPAARTQVVVTAQPWEAADPALCTPPHWEAVTGEGALTAKQQQAHDWLRAHGPQPSLGAWASGAKVGLPVVRKVADLGWAQEHPQAVPPPPAWKWLREHGPVASPAAWASAAGVRPAEVRRLMEGGAADYTFTPVTPPAAWAWLREHGPAETVSAWATGAGVSPSVAAGLLARGWAAQVQMPAPPPELPAAPLWAGPPLDELTALAADALPEEDRWRLHGGRPASRFAALAPRVARLLAQGRSVLILAPDHATLRRAWAGLGGLAALAGTRAALLSGQLSPRQREEIWRQVRAGDVRLVIGSALALSAPLPDLALLVVLEEGSDAYKLLSGSRAFVPDVAARVARSLRAALGLVGSVPAVESVPLPGLVLAPPRARVHVVDYAQPPAQPELGPLSSVHLTPGDLGYPISHDLARLLRQVQERGRQAALLAPRRGYSALLRCPRCDHVPGCPNCDVPLRFHQDRRQMECHQCGHHQSVPDRCDECGEQMWKARGPGTEWIAAEVEKLLPGFPVYRLDKDHQDDLAPLHAGEAGVVVGTQLLLAQPSPPNLALIGVTLADTWLGVSDFRASERYHRLLRQLAEWHPSRAPLLVVQTFQGDHPALKVLETGRDALAYPAAEERVRAELFYPPHARLAQIEVAARDRDRAKVAAQALADALHGAGAVATEVLGPAHAAVARVRGAYLYQLLLRARNDARLAELLGVLDTRSWGARVRVDVNPRST", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more PriA_3primeBD, PriA_CRR, PriA_C that are essential for its biological function; 2. The protein should belong to PriA, PriA_helicase, PriA that shares evolutionary origin and functional similarity; 3. The protein should be classified within P-loop_NTPase, P-loop_NTPase sharing conserved structural features. The designed protein sequence is ", "reference": "MTLWTVSPPAVSSEAEEKPVQDTVSLTAADQTWQVCVPLPIAALDFAAPHGYVGEVPLGCRVAVPWRGGEIRVGLVVGAGSSMGRHRLREALALLDSPEAPWVAPGTARGLTAWAEEAHLPPGLVWDDLLCTGWEPAHRHEVRAVPGADLSPYGETLPDTDWSRADLYPPALLDAAREQGLLDDRFLPDPPQVNRVVARDLNDVPPAARTQVVVTAQPWEAADPALCTPPHWEAVTGEGALTAKQQQAHDWLRAHGPQPSLGAWASGAKVGLPVVRKVADLGWAQEHPQAVPPPPAWKWLREHGPVASPAAWASAAGVRPAEVRRLMEGGAADYTFTPVTPPAAWAWLREHGPAETVSAWATGAGVSPSVAAGLLARGWAAQVQMPAPPPELPAAPLWAGPPLDELTALAADALPEEDRWRLHGGRPASRFAALAPRVARLLAQGRSVLILAPDHATLRRAWAGLGGLAALAGTRAALLSGQLSPRQREEIWRQVRAGDVRLVIGSALALSAPLPDLALLVVLEEGSDAYKLLSGSRAFVPDVAARVARSLRAALGLVGSVPAVESVPLPGLVLAPPRARVHVVDYAQPPAQPELGPLSSVHLTPGDLGYPISHDLARLLRQVQERGRQAALLAPRRGYSALLRCPRCDHVPGCPNCDVPLRFHQDRRQMECHQCGHHQSVPDRCDECGEQMWKARGPGTEWIAAEVEKLLPGFPVYRLDKDHQDDLAPLHAGEAGVVVGTQLLLAQPSPPNLALIGVTLADTWLGVSDFRASERYHRLLRQLAEWHPSRAPLLVVQTFQGDHPALKVLETGRDALAYPAAEERVRAELFYPPHARLAQIEVAARDRDRAKVAAQALADALHGAGAVATEVLGPAHAAVARVRGAYLYQLLLRARNDARLAELLGVLDTRSWGARVRVDVNPRST" }, { "InterPro": [ { "InterPro-ID": "IPR036291", "InterPro-Name": "NAD(P)-bd_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 2, "End": 248 }, { "InterPro-ID": "IPR002347", "InterPro-Name": "SDR_fam", "InterPro-Type": "FAMILY", "Beg": 133, "End": 141 }, { "InterPro-ID": "IPR002347", "InterPro-Name": "SDR_fam", "InterPro-Type": "FAMILY", "Beg": 76, "End": 87 }, { "InterPro-ID": "IPR002347", "InterPro-Name": "SDR_fam", "InterPro-Type": "FAMILY", "Beg": 153, "End": 172 }, { "InterPro-ID": "IPR002347", "InterPro-Name": "SDR_fam", "InterPro-Type": "FAMILY", "Beg": 127, "End": 143 }, { "InterPro-ID": "IPR002347", "InterPro-Name": "SDR_fam", "InterPro-Type": "FAMILY", "Beg": 3, "End": 20 }, { "InterPro-ID": "IPR002347", "InterPro-Name": "SDR_fam", "InterPro-Type": "FAMILY", "Beg": 174, "End": 191 }, { "InterPro-ID": "IPR002347", "InterPro-Name": "SDR_fam", "InterPro-Type": "FAMILY", "Beg": 3, "End": 194 }, { "InterPro-ID": "IPR020904", "InterPro-Name": "Sc_DH/Rdtase_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 140, "End": 168 } ], "response#1": "MRYAVVTGVSSGIGKAICEKFLAKGLYVFGSVRKKEDAKYFEEKYPNTFHTLVFDTTDYPAVDKAVEEIHKVVGKKGLSVLVNNAGVAKYGPIQHVPIEELRQQYEVNVFASVYLTQKLLWLLGASKEAKWQGKVIQISSTAGVMTRPMLGPYSSSKHAVEAIYDALRRELMIYGVEVVLIEPGPIKTEIWGKAKSGGNPYKDTDYGEIFAQLDKAVDEIEKIGLPVEAVAGKAWEAFVAKKPKARYVVAPKKLMFKAAMYLIPDRMLDKIFYKDLKKLTQES", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to SDR_fam, SDR_fam, SDR_fam, SDR_fam, SDR_fam, SDR_fam, SDR_fam that shares evolutionary origin and functional similarity; 2. The protein should be classified within NAD(P)-bd_dom_sf sharing conserved structural features; 3. The protein should contain Sc_DH/Rdtase_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MRYAVVTGVSSGIGKAICEKFLAKGLYVFGSVRKKEDAKYFEEKYPNTFHTLVFDTTDYPAVDKAVEEIHKVVGKKGLSVLVNNAGVAKYGPIQHVPIEELRQQYEVNVFASVYLTQKLLWLLGASKEAKWQGKVIQISSTAGVMTRPMLGPYSSSKHAVEAIYDALRRELMIYGVEVVLIEPGPIKTEIWGKAKSGGNPYKDTDYGEIFAQLDKAVDEIEKIGLPVEAVAGKAWEAFVAKKPKARYVVAPKKLMFKAAMYLIPDRMLDKIFYKDLKKLTQES" }, { "InterPro": [ { "InterPro-ID": "IPR002347", "InterPro-Name": "SDR_fam", "InterPro-Type": "FAMILY", "Beg": 40, "End": 168 }, { "InterPro-ID": "IPR036291", "InterPro-Name": "NAD(P)-bd_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 37, "End": 285 }, { "InterPro-ID": "IPR002347", "InterPro-Name": "SDR_fam", "InterPro-Type": "FAMILY", "Beg": 118, "End": 129 }, { "InterPro-ID": "IPR002347", "InterPro-Name": "SDR_fam", "InterPro-Type": "FAMILY", "Beg": 234, "End": 251 }, { "InterPro-ID": "IPR002347", "InterPro-Name": "SDR_fam", "InterPro-Type": "FAMILY", "Beg": 41, "End": 58 } ], "response#1": "MVSSKELPPSTVPFFPNQFFRNQFRSKPQYPPPNTNLSEKVAIISGGNTGLGFEAATQLLSFKLGTLILAVRSTAKGEAAASKLRARYPKATIHVWKLDMSSYDSIQEFAGRVNTQLPRLDMVILNAGVSKLEFGTVSSTGHEETVQINYLSTALLAILLLPALKSKSPPGIPGRLTIVSAALTLVAKFPNRDESPLLPSFDNPKYWDPNDQYCSSKLLMHLFLWKLVDYISADDVIVNLADPGFVKGTELARDVSGGQRVGLSIFASLTGRNKKHGASTYVDAVVNKGKESHGGFIMSWQIHPYPTLLYTSEGQQITERLWDETLAEFEFANVRGIIESMKGN", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to SDR_fam, SDR_fam, SDR_fam, SDR_fam that shares evolutionary origin and functional similarity; 2. The protein should be classified within NAD(P)-bd_dom_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MVSSKELPPSTVPFFPNQFFRNQFRSKPQYPPPNTNLSEKVAIISGGNTGLGFEAATQLLSFKLGTLILAVRSTAKGEAAASKLRARYPKATIHVWKLDMSSYDSIQEFAGRVNTQLPRLDMVILNAGVSKLEFGTVSSTGHEETVQINYLSTALLAILLLPALKSKSPPGIPGRLTIVSAALTLVAKFPNRDESPLLPSFDNPKYWDPNDQYCSSKLLMHLFLWKLVDYISADDVIVNLADPGFVKGTELARDVSGGQRVGLSIFASLTGRNKKHGASTYVDAVVNKGKESHGGFIMSWQIHPYPTLLYTSEGQQITERLWDETLAEFEFANVRGIIESMKGN" }, { "InterPro": [ { "InterPro-ID": "IPR012526", "InterPro-Name": "Antimicrobial_7", "InterPro-Type": "FAMILY", "Beg": 23, "End": 64 } ], "response#1": "MNRKLLLVTLMVTMLVMQPAEAGVWDWIKKTAGKIWNSEPVKALKSQALNAAKNFVAEKIGATPSEAGQMPFDEFMDILYES", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Antimicrobial_7 that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MNRKLLLVTLMVTMLVMQPAEAGVWDWIKKTAGKIWNSEPVKALKSQALNAAKNFVAEKIGATPSEAGQMPFDEFMDILYES" }, { "InterPro": [ { "InterPro-ID": "IPR017853", "InterPro-Name": "Glycoside_hydrolase_SF", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 31, "End": 493 }, { "InterPro-ID": "IPR006047", "InterPro-Name": "Glyco_hydro_13_cat_dom", "InterPro-Type": "DOMAIN", "Beg": 41, "End": 438 }, { "InterPro-ID": "IPR006047", "InterPro-Name": "Glyco_hydro_13_cat_dom", "InterPro-Type": "DOMAIN", "Beg": 41, "End": 498 }, { "InterPro-ID": "IPR045857", "InterPro-Name": "O16G_dom_2", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 133, "End": 206 } ], "response#1": "MPPLGVLLLLVALGHSTQGHRPLPIRKAHKFDWWERGNFYQIYPRSFKDSDGDGIGDLKGITQTIDYLKTIGIDGVWLSPIFKSPMNDFGYDISDFYAIQEEYGTMEDFEELAAKCASIGLKLILDFVPNHSSDEHEHFRLSEEGIEPYKDYYIWHSGVLDANGTRHPPSNWISVFRGSAWQWSDKRQQYYLHQFQKKQPDLNYRNPALVEEMKNVMRFWLNKGIAGFRIDALPYLFESEEVDGHYRDEPLSGQATDDPDNPAYLTHTETKDQPETYDMVHQWRQVVDEYTARDNFTRIILTEAYTAVQNMTRFYGTPAAPGAQIPFNFQLITLLTVNSTGRDFVNAVQSWTRAMPSGAIANWVLGNHDNSRIASRLGVARADLYNIALQTLPGIAVTYYGEEIAMVDQWISWNDTIDPAACNADPATYELYSRDPVRTPFQWSNGTNAGFSNASRTWLPVADGYRELNVAAQLAAPRSHLKTFMQLTAYRKRRLLAEGNFVLRTVGRDLVMYKRSVPGVGYVVVALNFGPEPATLPVASQFPGTGEHWLKVIASSLQAQPQAGTWINTRLYKLAPDSGIVLERLTGRNDLMT", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Glyco_hydro_13_cat_dom, Glyco_hydro_13_cat_dom that are essential for its biological function; 2. The protein should be classified within Glycoside_hydrolase_SF, O16G_dom_2 sharing conserved structural features. The designed protein sequence is ", "reference": "MPPLGVLLLLVALGHSTQGHRPLPIRKAHKFDWWERGNFYQIYPRSFKDSDGDGIGDLKGITQTIDYLKTIGIDGVWLSPIFKSPMNDFGYDISDFYAIQEEYGTMEDFEELAAKCASIGLKLILDFVPNHSSDEHEHFRLSEEGIEPYKDYYIWHSGVLDANGTRHPPSNWISVFRGSAWQWSDKRQQYYLHQFQKKQPDLNYRNPALVEEMKNVMRFWLNKGIAGFRIDALPYLFESEEVDGHYRDEPLSGQATDDPDNPAYLTHTETKDQPETYDMVHQWRQVVDEYTARDNFTRIILTEAYTAVQNMTRFYGTPAAPGAQIPFNFQLITLLTVNSTGRDFVNAVQSWTRAMPSGAIANWVLGNHDNSRIASRLGVARADLYNIALQTLPGIAVTYYGEEIAMVDQWISWNDTIDPAACNADPATYELYSRDPVRTPFQWSNGTNAGFSNASRTWLPVADGYRELNVAAQLAAPRSHLKTFMQLTAYRKRRLLAEGNFVLRTVGRDLVMYKRSVPGVGYVVVALNFGPEPATLPVASQFPGTGEHWLKVIASSLQAQPQAGTWINTRLYKLAPDSGIVLERLTGRNDLMT" }, { "InterPro": [ { "InterPro-ID": "IPR017930", "InterPro-Name": "Myb_dom", "InterPro-Type": "DOMAIN", "Beg": 113, "End": 162 }, { "InterPro-ID": "IPR001005", "InterPro-Name": "SANT/Myb", "InterPro-Type": "DOMAIN", "Beg": 63, "End": 106 }, { "InterPro-ID": "IPR017930", "InterPro-Name": "Myb_dom", "InterPro-Type": "DOMAIN", "Beg": 1, "End": 51 }, { "InterPro-ID": "IPR001005", "InterPro-Name": "SANT/Myb", "InterPro-Type": "DOMAIN", "Beg": 56, "End": 106 }, { "InterPro-ID": "IPR001005", "InterPro-Name": "SANT/Myb", "InterPro-Type": "DOMAIN", "Beg": 4, "End": 57 }, { "InterPro-ID": "IPR001005", "InterPro-Name": "SANT/Myb", "InterPro-Type": "DOMAIN", "Beg": 111, "End": 160 }, { "InterPro-ID": "IPR001005", "InterPro-Name": "SANT/Myb", "InterPro-Type": "DOMAIN", "Beg": 60, "End": 108 }, { "InterPro-ID": "IPR001005", "InterPro-Name": "SANT/Myb", "InterPro-Type": "DOMAIN", "Beg": 7, "End": 55 }, { "InterPro-ID": "IPR009057", "InterPro-Name": "Homeodomain-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 4, "End": 64 }, { "InterPro-ID": "IPR001005", "InterPro-Name": "SANT/Myb", "InterPro-Type": "DOMAIN", "Beg": 115, "End": 157 }, { "InterPro-ID": "IPR001005", "InterPro-Name": "SANT/Myb", "InterPro-Type": "DOMAIN", "Beg": 5, "End": 55 }, { "InterPro-ID": "IPR009057", "InterPro-Name": "Homeodomain-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 60, "End": 154 }, { "InterPro-ID": "IPR017930", "InterPro-Name": "Myb_dom", "InterPro-Type": "DOMAIN", "Beg": 56, "End": 110 }, { "InterPro-ID": "IPR001005", "InterPro-Name": "SANT/Myb", "InterPro-Type": "DOMAIN", "Beg": 107, "End": 158 }, { "InterPro-ID": "IPR001005", "InterPro-Name": "SANT/Myb", "InterPro-Type": "DOMAIN", "Beg": 5, "End": 53 }, { "InterPro-ID": "IPR001005", "InterPro-Name": "SANT/Myb", "InterPro-Type": "DOMAIN", "Beg": 114, "End": 157 }, { "InterPro-ID": "IPR001005", "InterPro-Name": "SANT/Myb", "InterPro-Type": "DOMAIN", "Beg": 61, "End": 106 }, { "InterPro-ID": "IPR050560", "InterPro-Name": "MYB_TF", "InterPro-Type": "FAMILY", "Beg": 61, "End": 176 } ], "response#1": "MARLRRRWTAEEDTLLRRAVENATTQGRPLLWRDLAKSVPGRSNKDCRRRWWNSLADGTTKGPWCEEEDERLIEAVRKYGTNWSRVSRAIRSRNPDQCSSHWSQVLDPGINYCDWTPEEDANLLHAVLTHSTNWATIAASHVPPRTRLALKNRYSTLRLKHENESKRESTIRKSVETPPSNFEPTMAISKDVKWTPPAQIHQGRGPDPVDVLIESDEEEDDDDDDEDNEEDDGDDENRGDGNSKNSMPHIELGNSLNGVDNGAVDIQMQDTGVTASNDWADFTEPSALPPLDYFHHDAQHIPMDSWANDTESHVQYEDLLELTPGENYLCDMDDSGAMNTGVQYKSYGSTPTNIDLSNPIGFHELHRTVEIFPSTTTGMDSSSAPGSRDTPPSMHFGTSASTTPRTSISGWSHQSAHYQVCVNMICTGAQMESLMTGLASLGTCITMKIDIKEDKAPLENQL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Myb_dom, SANT/Myb, Myb_dom, SANT/Myb, SANT/Myb, SANT/Myb, SANT/Myb, SANT/Myb, SANT/Myb, SANT/Myb, Myb_dom, SANT/Myb, SANT/Myb, SANT/Myb, SANT/Myb that are essential for its biological function; 2. The protein should belong to MYB_TF that shares evolutionary origin and functional similarity; 3. The protein should be classified within Homeodomain-like_sf, Homeodomain-like_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MARLRRRWTAEEDTLLRRAVENATTQGRPLLWRDLAKSVPGRSNKDCRRRWWNSLADGTTKGPWCEEEDERLIEAVRKYGTNWSRVSRAIRSRNPDQCSSHWSQVLDPGINYCDWTPEEDANLLHAVLTHSTNWATIAASHVPPRTRLALKNRYSTLRLKHENESKRESTIRKSVETPPSNFEPTMAISKDVKWTPPAQIHQGRGPDPVDVLIESDEEEDDDDDDEDNEEDDGDDENRGDGNSKNSMPHIELGNSLNGVDNGAVDIQMQDTGVTASNDWADFTEPSALPPLDYFHHDAQHIPMDSWANDTESHVQYEDLLELTPGENYLCDMDDSGAMNTGVQYKSYGSTPTNIDLSNPIGFHELHRTVEIFPSTTTGMDSSSAPGSRDTPPSMHFGTSASTTPRTSISGWSHQSAHYQVCVNMICTGAQMESLMTGLASLGTCITMKIDIKEDKAPLENQL" }, { "InterPro": [ { "InterPro-ID": "IPR050121", "InterPro-Name": "Cytochrome_P450_monoxygenase", "InterPro-Type": "FAMILY", "Beg": 7, "End": 481 }, { "InterPro-ID": "IPR002403", "InterPro-Name": "Cyt_P450_E_grp-IV", "InterPro-Type": "FAMILY", "Beg": 453, "End": 471 }, { "InterPro-ID": "IPR002403", "InterPro-Name": "Cyt_P450_E_grp-IV", "InterPro-Type": "FAMILY", "Beg": 437, "End": 453 }, { "InterPro-ID": "IPR002403", "InterPro-Name": "Cyt_P450_E_grp-IV", "InterPro-Type": "FAMILY", "Beg": 394, "End": 408 }, { "InterPro-ID": "IPR002403", "InterPro-Name": "Cyt_P450_E_grp-IV", "InterPro-Type": "FAMILY", "Beg": 359, "End": 375 }, { "InterPro-ID": "IPR036396", "InterPro-Name": "Cyt_P450_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 25, "End": 504 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 39, "End": 488 }, { "InterPro-ID": "IPR036396", "InterPro-Name": "Cyt_P450_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 24, "End": 511 }, { "InterPro-ID": "IPR017972", "InterPro-Name": "Cyt_P450_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 446, "End": 455 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 364, "End": 375 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 453, "End": 464 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 444, "End": 453 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 311, "End": 328 } ], "response#1": "MDKISIIPIVGVALSLAIILQLGRTYWRLRHIPGPFPACITNFQRVGWVKTKRAHLILQDMHKKYGEVVRIGPNMVSFSNPEVIPTVYPARSGFPKGDFYVTLRPYTRGGGALHAVFNTTEEDLHKQIKSPIAPMFTPANTPSFEGLVDEVLTCIHEKLDENFIANSEIFNLGQWLQYFAFDVMGTMTFSKRYGFLDTGKDVGRMLGTIVDFMRDAAPMTQIPWLDWALRKNRIGDSIQRLFGKTASLGILGFVGKAIKERQELLSKGDFKVSDEKSGRKDFLTRFIELQQNDPKIPPWAPTAWTFSNVIAGSDSVGSLMRTTMFNLLVYPHTLEKLHDELRSAGVSRPYPKWSEIRNLLYLDACVQEGARMHPPFALPFERVVPAGGITILGYYLPGGTVVGGSPYVVNRHRETFGRDAEFWRPERWLESDEGHKRKLEQGVLTFGAGRRVCLGKHVGILEIKKLISFLVLNYDIRVVNPEKFELENSWFFFQRGLYATIRKRPDAVAVKNQQV", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Cytochrome_P450_monoxygenase, Cyt_P450_E_grp-IV, Cyt_P450_E_grp-IV, Cyt_P450_E_grp-IV, Cyt_P450_E_grp-IV, Cyt_P450, Cyt_P450, Cyt_P450, Cyt_P450, Cyt_P450 that shares evolutionary origin and functional similarity; 2. The protein should be classified within Cyt_P450_sf, Cyt_P450_sf sharing conserved structural features; 3. The protein should contain Cyt_P450_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MDKISIIPIVGVALSLAIILQLGRTYWRLRHIPGPFPACITNFQRVGWVKTKRAHLILQDMHKKYGEVVRIGPNMVSFSNPEVIPTVYPARSGFPKGDFYVTLRPYTRGGGALHAVFNTTEEDLHKQIKSPIAPMFTPANTPSFEGLVDEVLTCIHEKLDENFIANSEIFNLGQWLQYFAFDVMGTMTFSKRYGFLDTGKDVGRMLGTIVDFMRDAAPMTQIPWLDWALRKNRIGDSIQRLFGKTASLGILGFVGKAIKERQELLSKGDFKVSDEKSGRKDFLTRFIELQQNDPKIPPWAPTAWTFSNVIAGSDSVGSLMRTTMFNLLVYPHTLEKLHDELRSAGVSRPYPKWSEIRNLLYLDACVQEGARMHPPFALPFERVVPAGGITILGYYLPGGTVVGGSPYVVNRHRETFGRDAEFWRPERWLESDEGHKRKLEQGVLTFGAGRRVCLGKHVGILEIKKLISFLVLNYDIRVVNPEKFELENSWFFFQRGLYATIRKRPDAVAVKNQQV" }, { "InterPro": [ { "InterPro-ID": "IPR036866", "InterPro-Name": "RibonucZ/Hydroxyglut_hydro", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 22, "End": 256 }, { "InterPro-ID": "IPR036866", "InterPro-Name": "RibonucZ/Hydroxyglut_hydro", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 24, "End": 322 }, { "InterPro-ID": "IPR001279", "InterPro-Name": "Metallo-B-lactamas", "InterPro-Type": "DOMAIN", "Beg": 56, "End": 214 }, { "InterPro-ID": "IPR051013", "InterPro-Name": "MBL_superfamily_lactonases", "InterPro-Type": "FAMILY", "Beg": 16, "End": 336 }, { "InterPro-ID": "IPR001279", "InterPro-Name": "Metallo-B-lactamas", "InterPro-Type": "DOMAIN", "Beg": 55, "End": 268 } ], "response#1": "MVTKPTTPKPPPALGIPDSAYTVDVRVIDTGTLLHLNPSLFWQPPIDGFTGLHAPIYCFLVSHGSQHVIFDLGVRTDWENYAPKIVSIIKATTTVTPGSDVPSMLDEDTSGLGIRSADIGAVIWSHNHFDHVGDVSRFPLTTDLIVGPGVRGVSWPGWPSNPDGIVLDSDVEGRVVREVSFEAGLKIGHFDAMDFFGDGSFYLLDAPGHAVGHLCALARTTANEPTFVFMGADACHHPGLLRPSNYLPLPSASTLAGVLTGPPQCPGELLQQLTLPDEPFFTVAPRMFPDHDAATDTVRKIQELDASDNCLVLIAHDLSLRDKIPLFPKTINGWKESQVKTETRWLFCNDFMPALHHLDNKQGIEEELGKQSSLKCS", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Metallo-B-lactamas, Metallo-B-lactamas that are essential for its biological function; 2. The protein should belong to MBL_superfamily_lactonases that shares evolutionary origin and functional similarity; 3. The protein should be classified within RibonucZ/Hydroxyglut_hydro, RibonucZ/Hydroxyglut_hydro sharing conserved structural features. The designed protein sequence is ", "reference": "MVTKPTTPKPPPALGIPDSAYTVDVRVIDTGTLLHLNPSLFWQPPIDGFTGLHAPIYCFLVSHGSQHVIFDLGVRTDWENYAPKIVSIIKATTTVTPGSDVPSMLDEDTSGLGIRSADIGAVIWSHNHFDHVGDVSRFPLTTDLIVGPGVRGVSWPGWPSNPDGIVLDSDVEGRVVREVSFEAGLKIGHFDAMDFFGDGSFYLLDAPGHAVGHLCALARTTANEPTFVFMGADACHHPGLLRPSNYLPLPSASTLAGVLTGPPQCPGELLQQLTLPDEPFFTVAPRMFPDHDAATDTVRKIQELDASDNCLVLIAHDLSLRDKIPLFPKTINGWKESQVKTETRWLFCNDFMPALHHLDNKQGIEEELGKQSSLKCS" }, { "InterPro": [ { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 429, "End": 439 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 351, "End": 369 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 180, "End": 198 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 307, "End": 333 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 287, "End": 304 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 439, "End": 462 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 393, "End": 417 }, { "InterPro-ID": "IPR036396", "InterPro-Name": "Cyt_P450_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 33, "End": 494 }, { "InterPro-ID": "IPR017972", "InterPro-Name": "Cyt_P450_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 432, "End": 441 }, { "InterPro-ID": "IPR050121", "InterPro-Name": "Cytochrome_P450_monoxygenase", "InterPro-Type": "FAMILY", "Beg": 21, "End": 467 }, { "InterPro-ID": "IPR036396", "InterPro-Name": "Cyt_P450_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 27, "End": 496 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 61, "End": 467 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 352, "End": 363 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 439, "End": 450 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 430, "End": 439 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 298, "End": 315 } ], "response#1": "MDVAMRVEWLATPRVILGIGAGWVAYALCLDPLRHIPGPRLNAVSMIPYARHLLAGTTVQNSVSLHQQYGEVVRIAPNEVSLICGETAFPDIYGRLFITSQTMGQIRANSAVCRVSDGKDERASKYVQGRRVLAHAFSDKALMGQEPLVQRYVDQLIDRLKEVTSANDEPVDMVKWYNWTTFDVIADLLFGEPFGCLQDLSTHQYVALLFQSLKSLRMIYILAYYPWLRFLGNLIVDKGLIQKRKEYATWVSTQVTKRINTATPRPDFMSHILANNNNRGVKLTRAEIDSNATLMTTAGSETTATLLSGATYLLLTHPRVLRTLQDEIHSEFPTYESITLEAVAKRTPYLNAVISEALRFFPPIPVGFIRRVPKGGETVSGYWIPEGTILSVSHYAAYHSERNFRDPDSWVPERWLGDERYVNDKRAAFQPFSFGPRSCLGRNLAYAEMRLILAKMVWSFEMELDEGLSRDWLQRCRVMRLWQKPELEVRVRPRVVA", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Cyt_P450_E_grp-I, Cyt_P450_E_grp-I, Cyt_P450_E_grp-I, Cyt_P450_E_grp-I, Cyt_P450_E_grp-I, Cyt_P450_E_grp-I, Cyt_P450_E_grp-I, Cytochrome_P450_monoxygenase, Cyt_P450, Cyt_P450, Cyt_P450, Cyt_P450, Cyt_P450 that shares evolutionary origin and functional similarity; 2. The protein should be classified within Cyt_P450_sf, Cyt_P450_sf sharing conserved structural features; 3. The protein should contain Cyt_P450_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MDVAMRVEWLATPRVILGIGAGWVAYALCLDPLRHIPGPRLNAVSMIPYARHLLAGTTVQNSVSLHQQYGEVVRIAPNEVSLICGETAFPDIYGRLFITSQTMGQIRANSAVCRVSDGKDERASKYVQGRRVLAHAFSDKALMGQEPLVQRYVDQLIDRLKEVTSANDEPVDMVKWYNWTTFDVIADLLFGEPFGCLQDLSTHQYVALLFQSLKSLRMIYILAYYPWLRFLGNLIVDKGLIQKRKEYATWVSTQVTKRINTATPRPDFMSHILANNNNRGVKLTRAEIDSNATLMTTAGSETTATLLSGATYLLLTHPRVLRTLQDEIHSEFPTYESITLEAVAKRTPYLNAVISEALRFFPPIPVGFIRRVPKGGETVSGYWIPEGTILSVSHYAAYHSERNFRDPDSWVPERWLGDERYVNDKRAAFQPFSFGPRSCLGRNLAYAEMRLILAKMVWSFEMELDEGLSRDWLQRCRVMRLWQKPELEVRVRPRVVA" }, { "InterPro": [ { "InterPro-ID": "IPR037523", "InterPro-Name": "VOC", "InterPro-Type": "DOMAIN", "Beg": 2, "End": 119 }, { "InterPro-ID": "IPR029068", "InterPro-Name": "Glyas_Bleomycin-R_OHBP_Dase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1, "End": 123 }, { "InterPro-ID": "IPR052393", "InterPro-Name": "Cadmium-induced_rsp", "InterPro-Type": "FAMILY", "Beg": 1, "End": 160 }, { "InterPro-ID": "IPR004360", "InterPro-Name": "Glyas_Fos-R_dOase_dom", "InterPro-Type": "DOMAIN", "Beg": 3, "End": 116 }, { "InterPro-ID": "IPR049789", "InterPro-Name": "YqcK/CadI-like", "InterPro-Type": "FAMILY", "Beg": 4, "End": 160 }, { "InterPro-ID": "IPR029068", "InterPro-Name": "Glyas_Bleomycin-R_OHBP_Dase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1, "End": 125 } ], "response#1": "MKYAHVGLNVTNLEKSIEFYSKLFGAEPVKVKPDYAKFLLESPGLNFTLNLRDEVNGNQVGHFGIQVESTEEVVAHKNRLAENGILSQYDEINTTCCYALQDKFWIHDPDGNEWEFFYTKTTVEENSTHPPTCCVNEPNVEKAECCSPTASSNKDTSNCCS", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more VOC, Glyas_Fos-R_dOase_dom that are essential for its biological function; 2. The protein should belong to Cadmium-induced_rsp, YqcK/CadI-like that shares evolutionary origin and functional similarity; 3. The protein should be classified within Glyas_Bleomycin-R_OHBP_Dase, Glyas_Bleomycin-R_OHBP_Dase sharing conserved structural features. The designed protein sequence is ", "reference": "MKYAHVGLNVTNLEKSIEFYSKLFGAEPVKVKPDYAKFLLESPGLNFTLNLRDEVNGNQVGHFGIQVESTEEVVAHKNRLAENGILSQYDEINTTCCYALQDKFWIHDPDGNEWEFFYTKTTVEENSTHPPTCCVNEPNVEKAECCSPTASSNKDTSNCCS" }, { "InterPro": [ { "InterPro-ID": "IPR013149", "InterPro-Name": "ADH-like_C", "InterPro-Type": "DOMAIN", "Beg": 181, "End": 265 }, { "InterPro-ID": "IPR020843", "InterPro-Name": "PKS_ER", "InterPro-Type": "DOMAIN", "Beg": 19, "End": 363 }, { "InterPro-ID": "IPR047122", "InterPro-Name": "Trans-enoyl_RdTase-like", "InterPro-Type": "FAMILY", "Beg": 12, "End": 364 }, { "InterPro-ID": "IPR013154", "InterPro-Name": "ADH-like_N", "InterPro-Type": "DOMAIN", "Beg": 36, "End": 124 }, { "InterPro-ID": "IPR011032", "InterPro-Name": "GroES-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 8, "End": 182 }, { "InterPro-ID": "IPR036291", "InterPro-Name": "NAD(P)-bd_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 126, "End": 323 }, { "InterPro-ID": "IPR047122", "InterPro-Name": "Trans-enoyl_RdTase-like", "InterPro-Type": "FAMILY", "Beg": 9, "End": 366 } ], "response#1": "MPSATPVIPSQQTAIVAEGAGQLSIYHDAPVPALQPDVALVKTAAVAINPVDAKMLDYSPVPGAIHGYDFAGTIVALGSDTPPHLKVGDRVAGFVHGMNPLLPDVGAFAEYVAASADLVLKLPDTMSFEEGASLGLGLFTAGLGLFQHLQIPLSLTREPSPEASSPTKADFVLVAGGSTATGTRALQLLKLAGLRPVATCSPAHFDLARRFGAEAVFDYHDPDCAAAIRAYTKNTLAYALDCLALAETTQLCYGALGRAGGRYVTLEPFREAIAAQRPHTVTPSWLLALTIFGRKVALDGEYGREANPEDREFGARLTEQVQGLLDEGKVDVHPVRVMGGGWQGVLEGVDLVRRQTVSGHKLVYAV", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more ADH-like_C, PKS_ER, ADH-like_N that are essential for its biological function; 2. The protein should belong to Trans-enoyl_RdTase-like, Trans-enoyl_RdTase-like that shares evolutionary origin and functional similarity; 3. The protein should be classified within GroES-like_sf, NAD(P)-bd_dom_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MPSATPVIPSQQTAIVAEGAGQLSIYHDAPVPALQPDVALVKTAAVAINPVDAKMLDYSPVPGAIHGYDFAGTIVALGSDTPPHLKVGDRVAGFVHGMNPLLPDVGAFAEYVAASADLVLKLPDTMSFEEGASLGLGLFTAGLGLFQHLQIPLSLTREPSPEASSPTKADFVLVAGGSTATGTRALQLLKLAGLRPVATCSPAHFDLARRFGAEAVFDYHDPDCAAAIRAYTKNTLAYALDCLALAETTQLCYGALGRAGGRYVTLEPFREAIAAQRPHTVTPSWLLALTIFGRKVALDGEYGREANPEDREFGARLTEQVQGLLDEGKVDVHPVRVMGGGWQGVLEGVDLVRRQTVSGHKLVYAV" }, { "InterPro": [ { "InterPro-ID": "IPR003709", "InterPro-Name": "Pept_M15B", "InterPro-Type": "DOMAIN", "Beg": 33, "End": 161 }, { "InterPro-ID": "IPR009045", "InterPro-Name": "Hedgehog_sig/DD-Pept_Zn-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 28, "End": 168 }, { "InterPro-ID": "IPR009045", "InterPro-Name": "Hedgehog_sig/DD-Pept_Zn-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1, "End": 190 }, { "InterPro-ID": "IPR052179", "InterPro-Name": "Bact_PeptidoProc_Enz", "InterPro-Type": "FAMILY", "Beg": 3, "End": 180 } ], "response#1": "MNTLQLINKNHPLKKNQEPPHLVLAPFSDHDVYLQPEVAKQWERLVRATGLEKDIRLVDGYRTEKEQRRLWEYSLKENGLAYTKQFVALPGCSEHQIGLAIDVGLKKQEDDDLICPHFRDSAAADLFMQQMMNYGFILRYPEDKQEITGISYEPWHFRYVGLPHSQVITAQKWTLEEYHDYLAQTVRQFA", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Pept_M15B that are essential for its biological function; 2. The protein should belong to Bact_PeptidoProc_Enz that shares evolutionary origin and functional similarity; 3. The protein should be classified within Hedgehog_sig/DD-Pept_Zn-bd_sf, Hedgehog_sig/DD-Pept_Zn-bd_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MNTLQLINKNHPLKKNQEPPHLVLAPFSDHDVYLQPEVAKQWERLVRATGLEKDIRLVDGYRTEKEQRRLWEYSLKENGLAYTKQFVALPGCSEHQIGLAIDVGLKKQEDDDLICPHFRDSAAADLFMQQMMNYGFILRYPEDKQEITGISYEPWHFRYVGLPHSQVITAQKWTLEEYHDYLAQTVRQFA" }, { "InterPro": [ { "InterPro-ID": "IPR000551", "InterPro-Name": "MerR-type_HTH_dom", "InterPro-Type": "DOMAIN", "Beg": 3, "End": 68 }, { "InterPro-ID": "IPR010499", "InterPro-Name": "AraC_E-bd", "InterPro-Type": "DOMAIN", "Beg": 120, "End": 270 }, { "InterPro-ID": "IPR029441", "InterPro-Name": "Cass2", "InterPro-Type": "DOMAIN", "Beg": 123, "End": 269 }, { "InterPro-ID": "IPR009061", "InterPro-Name": "DNA-bd_dom_put_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 2, "End": 108 }, { "InterPro-ID": "IPR000551", "InterPro-Name": "MerR-type_HTH_dom", "InterPro-Type": "DOMAIN", "Beg": 1, "End": 71 }, { "InterPro-ID": "IPR011256", "InterPro-Name": "Reg_factor_effector_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 124, "End": 270 }, { "InterPro-ID": "IPR047057", "InterPro-Name": "MerR_fam", "InterPro-Type": "FAMILY", "Beg": 1, "End": 131 }, { "InterPro-ID": "IPR000551", "InterPro-Name": "MerR-type_HTH_dom", "InterPro-Type": "DOMAIN", "Beg": 2, "End": 72 }, { "InterPro-ID": "IPR011256", "InterPro-Name": "Reg_factor_effector_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 120, "End": 269 } ], "response#1": "MLTIGQLARIFEISTKTLRHYDAIGLFVPARTGSDNGYRYYQPEQIEQLSRILALRRLDVPLEAIDRLKRDGALDDPQRLRHFLQRHQHTLREEISARQRLLAELDRTLATLAHWRIRNMHARIVERPAFSVVGMEYFGSAPGDTIGQLWERFIPREHEIAGKHDPEVSYGICAQQPNGEFHYVAGFEVQEGWPVPEGMVRFQVPAQKYAVFTHKGTAPQIAESFQAIYSHLLAERGLEPKAGVDFEYYDQRFRGPLDPNSQVDLYIPIY", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more MerR-type_HTH_dom, AraC_E-bd, Cass2, MerR-type_HTH_dom, MerR-type_HTH_dom that are essential for its biological function; 2. The protein should belong to MerR_fam that shares evolutionary origin and functional similarity; 3. The protein should be classified within DNA-bd_dom_put_sf, Reg_factor_effector_dom_sf, Reg_factor_effector_dom_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MLTIGQLARIFEISTKTLRHYDAIGLFVPARTGSDNGYRYYQPEQIEQLSRILALRRLDVPLEAIDRLKRDGALDDPQRLRHFLQRHQHTLREEISARQRLLAELDRTLATLAHWRIRNMHARIVERPAFSVVGMEYFGSAPGDTIGQLWERFIPREHEIAGKHDPEVSYGICAQQPNGEFHYVAGFEVQEGWPVPEGMVRFQVPAQKYAVFTHKGTAPQIAESFQAIYSHLLAERGLEPKAGVDFEYYDQRFRGPLDPNSQVDLYIPIY" }, { "InterPro": [ { "InterPro-ID": "IPR000536", "InterPro-Name": "Nucl_hrmn_rcpt_lig-bd", "InterPro-Type": "DOMAIN", "Beg": 310, "End": 498 }, { "InterPro-ID": "IPR001628", "InterPro-Name": "Znf_hrmn_rcpt", "InterPro-Type": "DOMAIN", "Beg": 43, "End": 118 }, { "InterPro-ID": "IPR001628", "InterPro-Name": "Znf_hrmn_rcpt", "InterPro-Type": "DOMAIN", "Beg": 45, "End": 112 }, { "InterPro-ID": "IPR000536", "InterPro-Name": "Nucl_hrmn_rcpt_lig-bd", "InterPro-Type": "DOMAIN", "Beg": 323, "End": 486 }, { "InterPro-ID": "IPR035500", "InterPro-Name": "NHR-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 112, "End": 515 }, { "InterPro-ID": "IPR001628", "InterPro-Name": "Znf_hrmn_rcpt", "InterPro-Type": "DOMAIN", "Beg": 46, "End": 72 }, { "InterPro-ID": "IPR000536", "InterPro-Name": "Nucl_hrmn_rcpt_lig-bd", "InterPro-Type": "DOMAIN", "Beg": 276, "End": 515 }, { "InterPro-ID": "IPR001723", "InterPro-Name": "Nuclear_hrmn_rcpt", "InterPro-Type": "FAMILY", "Beg": 474, "End": 491 }, { "InterPro-ID": "IPR001723", "InterPro-Name": "Nuclear_hrmn_rcpt", "InterPro-Type": "FAMILY", "Beg": 324, "End": 345 }, { "InterPro-ID": "IPR001723", "InterPro-Name": "Nuclear_hrmn_rcpt", "InterPro-Type": "FAMILY", "Beg": 417, "End": 432 }, { "InterPro-ID": "IPR001723", "InterPro-Name": "Nuclear_hrmn_rcpt", "InterPro-Type": "FAMILY", "Beg": 107, "End": 117 }, { "InterPro-ID": "IPR001723", "InterPro-Name": "Nuclear_hrmn_rcpt", "InterPro-Type": "FAMILY", "Beg": 345, "End": 361 }, { "InterPro-ID": "IPR001628", "InterPro-Name": "Znf_hrmn_rcpt", "InterPro-Type": "DOMAIN", "Beg": 43, "End": 114 }, { "InterPro-ID": "IPR016355", "InterPro-Name": "NR5-like", "InterPro-Type": "FAMILY", "Beg": 1, "End": 517 }, { "InterPro-ID": "IPR016355", "InterPro-Name": "NR5-like", "InterPro-Type": "FAMILY", "Beg": 25, "End": 516 }, { "InterPro-ID": "IPR013088", "InterPro-Name": "Znf_NHR/GATA", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 36, "End": 147 }, { "InterPro-ID": "IPR001628", "InterPro-Name": "Znf_hrmn_rcpt", "InterPro-Type": "DOMAIN", "Beg": 103, "End": 111 }, { "InterPro-ID": "IPR001628", "InterPro-Name": "Znf_hrmn_rcpt", "InterPro-Type": "DOMAIN", "Beg": 95, "End": 103 }, { "InterPro-ID": "IPR001628", "InterPro-Name": "Znf_hrmn_rcpt", "InterPro-Type": "DOMAIN", "Beg": 46, "End": 62 }, { "InterPro-ID": "IPR001628", "InterPro-Name": "Znf_hrmn_rcpt", "InterPro-Type": "DOMAIN", "Beg": 62, "End": 77 }, { "InterPro-ID": "IPR035500", "InterPro-Name": "NHR-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 273, "End": 517 } ], "response#1": "MLPKVESEYLGLARSHGEQGHMPGNMQAPQFKMMDYSYDEDLDEMCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNNKRYTCIENQSCQIDKTQRKRCPYCRFQKCLTVGMKLEAVRADRMRGGRNKFGPMYKRDRALKQQKKALIRANGLKLEAMTQVMQTVPADLTITSAIQNIHSASKGLPLSHHHHHHHHHHHHSSSSAGLPPADFDRSPFVTSPVSMAMPPHAGGLQGYQAYGHFQSRTIKSEYPDPYTSSPESLMGYPYVEAYAGGSPPSFPHLVVELLKCEPDEPQVQAKILAYLQQEQASRGKHEKLNTFGLMCKMADQTLFSIVEWARSSIFFRELKVDDQMKLLQNCWSELLILDHVFRQVMHAKEGSILLVTGQQVDYALIASQAGATLNNLLSHAQELVSKLRSLQLDQREFVCLKFLVLFSLDVKNLENFHLVESVQEQVNAALLDYVMCNYPQQTDKFGQLLLRLPEIRAISLQAEEYLYYKHLNGDVPCNNLLIEMLHAKRA", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Nucl_hrmn_rcpt_lig-bd, Znf_hrmn_rcpt, Znf_hrmn_rcpt, Nucl_hrmn_rcpt_lig-bd, Znf_hrmn_rcpt, Nucl_hrmn_rcpt_lig-bd, Znf_hrmn_rcpt, Znf_hrmn_rcpt, Znf_hrmn_rcpt, Znf_hrmn_rcpt, Znf_hrmn_rcpt that are essential for its biological function; 2. The protein should belong to Nuclear_hrmn_rcpt, Nuclear_hrmn_rcpt, Nuclear_hrmn_rcpt, Nuclear_hrmn_rcpt, Nuclear_hrmn_rcpt, NR5-like, NR5-like that shares evolutionary origin and functional similarity; 3. The protein should be classified within NHR-like_dom_sf, Znf_NHR/GATA, NHR-like_dom_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MLPKVESEYLGLARSHGEQGHMPGNMQAPQFKMMDYSYDEDLDEMCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNNKRYTCIENQSCQIDKTQRKRCPYCRFQKCLTVGMKLEAVRADRMRGGRNKFGPMYKRDRALKQQKKALIRANGLKLEAMTQVMQTVPADLTITSAIQNIHSASKGLPLSHHHHHHHHHHHHSSSSAGLPPADFDRSPFVTSPVSMAMPPHAGGLQGYQAYGHFQSRTIKSEYPDPYTSSPESLMGYPYVEAYAGGSPPSFPHLVVELLKCEPDEPQVQAKILAYLQQEQASRGKHEKLNTFGLMCKMADQTLFSIVEWARSSIFFRELKVDDQMKLLQNCWSELLILDHVFRQVMHAKEGSILLVTGQQVDYALIASQAGATLNNLLSHAQELVSKLRSLQLDQREFVCLKFLVLFSLDVKNLENFHLVESVQEQVNAALLDYVMCNYPQQTDKFGQLLLRLPEIRAISLQAEEYLYYKHLNGDVPCNNLLIEMLHAKRA" }, { "InterPro": [ { "InterPro-ID": "IPR020843", "InterPro-Name": "PKS_ER", "InterPro-Type": "DOMAIN", "Beg": 61, "End": 405 }, { "InterPro-ID": "IPR037397", "InterPro-Name": "RTN4I1", "InterPro-Type": "FAMILY", "Beg": 52, "End": 406 }, { "InterPro-ID": "IPR011032", "InterPro-Name": "GroES-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 51, "End": 203 }, { "InterPro-ID": "IPR013154", "InterPro-Name": "ADH-like_N", "InterPro-Type": "DOMAIN", "Beg": 81, "End": 176 }, { "InterPro-ID": "IPR050700", "InterPro-Name": "YIM1/Zinc_Alcohol_DH_Fams", "InterPro-Type": "FAMILY", "Beg": 33, "End": 407 }, { "InterPro-ID": "IPR036291", "InterPro-Name": "NAD(P)-bd_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 179, "End": 404 } ], "response#1": "MTAAGFNSILCLRQLVRLNRRQYSAPAKSVLSGSQTNDQATPPPTSKSADKMRGWQLHNYGDIDELQLSEMLKIPQIRCSNECLVRIRATAVNPIDLAMLRGYGATVLNKMRCQPGDGIEFPLILGREFCGELVQTGMGVSLPLGSRVWGVVPLQATIGSHAEYVAVPSYCLAPAPKELDDYEAASVLYAGLTAWSGLYITGGLGGPCGATTASGGGAHKRVLVLGGSGGVGTLAIQILKSQKVQVLATCSENAIEMVRNLGADLVVDYNNPQAMEELCKYAPYDIVLDCAGQGGQKAAESKYDFRQYITFSSPLLANIDKQGLGVGALKNVFDLFQTNVRSVTQRGGLVKWGFFSPAPQGIQFLQKLVEQRKLMPLIDSSYGFSELPKAFEKMKSGHLRGKIVVKLREETGD", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more PKS_ER, ADH-like_N that are essential for its biological function; 2. The protein should belong to RTN4I1, YIM1/Zinc_Alcohol_DH_Fams that shares evolutionary origin and functional similarity; 3. The protein should be classified within GroES-like_sf, NAD(P)-bd_dom_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MTAAGFNSILCLRQLVRLNRRQYSAPAKSVLSGSQTNDQATPPPTSKSADKMRGWQLHNYGDIDELQLSEMLKIPQIRCSNECLVRIRATAVNPIDLAMLRGYGATVLNKMRCQPGDGIEFPLILGREFCGELVQTGMGVSLPLGSRVWGVVPLQATIGSHAEYVAVPSYCLAPAPKELDDYEAASVLYAGLTAWSGLYITGGLGGPCGATTASGGGAHKRVLVLGGSGGVGTLAIQILKSQKVQVLATCSENAIEMVRNLGADLVVDYNNPQAMEELCKYAPYDIVLDCAGQGGQKAAESKYDFRQYITFSSPLLANIDKQGLGVGALKNVFDLFQTNVRSVTQRGGLVKWGFFSPAPQGIQFLQKLVEQRKLMPLIDSSYGFSELPKAFEKMKSGHLRGKIVVKLREETGD" }, { "InterPro": [ { "InterPro-ID": "IPR003593", "InterPro-Name": "AAA+_ATPase", "InterPro-Type": "DOMAIN", "Beg": 835, "End": 1026 }, { "InterPro-ID": "IPR036640", "InterPro-Name": "ABC1_TM_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 351, "End": 657 }, { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 805, "End": 1043 }, { "InterPro-ID": "IPR003439", "InterPro-Name": "ABC_transporter-like_ATP-bd", "InterPro-Type": "DOMAIN", "Beg": 827, "End": 973 }, { "InterPro-ID": "IPR011527", "InterPro-Name": "ABC1_TM_dom", "InterPro-Type": "DOMAIN", "Beg": 360, "End": 651 }, { "InterPro-ID": "IPR039421", "InterPro-Name": "Type_1_exporter", "InterPro-Type": "FAMILY", "Beg": 810, "End": 1038 }, { "InterPro-ID": "IPR011527", "InterPro-Name": "ABC1_TM_dom", "InterPro-Type": "DOMAIN", "Beg": 357, "End": 639 }, { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 814, "End": 1042 }, { "InterPro-ID": "IPR036640", "InterPro-Name": "ABC1_TM_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 345, "End": 670 }, { "InterPro-ID": "IPR003439", "InterPro-Name": "ABC_transporter-like_ATP-bd", "InterPro-Type": "DOMAIN", "Beg": 807, "End": 1043 }, { "InterPro-ID": "IPR036640", "InterPro-Name": "ABC1_TM_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 786, "End": 804 } ], "response#1": "MRSFYNKCFTNKLISAHSLFCQHVSTLKNNKKECFEDVKRSNRISDEFYSSFLYHSYIENLKSTKEYVYFIYLQDIYYNINIFKNKGRLYISNNGLCNDKLKDNNNNNNINSNNFGNSYNAYTKKKSFYHSFNDLNEAKEIRKKRKNEKSEKNIVEYLLCNIINPNENYHIQNIYNHNLNNNVSIEIHKKNDSVMYHYNNEKKTKTSKMTTDIKLKQINNVYIKYVPYKNKIITLACPNKYYPTLYRYFSSHTNKKEDAEENDKNKNININNVDNRYKEDFMYGCENKNDSEKHKKTTNNNFGDEFEKLKVKELDKILNKLEMLYDNKNNKMNINVKILGYIFKNFLLKNKELKRKIFCSLFFLLCSKMAIIYTPILLSTFIENVNLQKSLSNNIDIYSTNKSSVLLLCAYVFSRVLSSTMNELRNSVFSNISQKISTFVSKLFFYKIHNLNLTYILSKKNGELSFIFNRGCKSITNLLNVMVFQIIPIIIEFILYLYILTYKIHYTVSLVTCFNMFLYVLFTTLITKRRTIIRKHMNKAEQNTFNIFLDSIQNVEQVKYYTNEIHELKKFIKEQKKYEKEAINVQKSLSFLNFGQQIILNTNLFLCMYLTYLNIANDIFPFSYLILVNTLLFQLAMPLNMFGTIYRETKLSLVDIESMIKILVKKIKSPDYGNQMLIKNGNIKFENVYFKYPLNEDINGLEQNYQAKEKDPNIINNINNINNINNINNINNINSINNIYTFESNVKNISSTNMITSSINKLKKWYLDKVKDNKKNVQYNNNDVKKTNPNITKNLNKEIKENINTHLKNHKIINNSPNYNNNNYLFQNFTCNIENGEKVAIIGKSGSGKSSLIKLLLKFYEVNSGNIYIDNKNIDDIDLYTLRKNISVVPQDTILFNNTISYNIKYGNFQCTDKQMIQASIKAELHDKIMKMENKYDTIVGERGTKLSIGEKQRICIARCFLKDSKIIVLDEHASNLDNENKKAIEKALTKLCMGKTTFIITHVMENLKHMDKIIFFCGKNIYVGSHKNLMDDNHFYREYYDSKNNKML", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more AAA+_ATPase, ABC_transporter-like_ATP-bd, ABC1_TM_dom, ABC1_TM_dom, ABC_transporter-like_ATP-bd that are essential for its biological function; 2. The protein should belong to Type_1_exporter that shares evolutionary origin and functional similarity; 3. The protein should be classified within ABC1_TM_sf, P-loop_NTPase, P-loop_NTPase, ABC1_TM_sf, ABC1_TM_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MRSFYNKCFTNKLISAHSLFCQHVSTLKNNKKECFEDVKRSNRISDEFYSSFLYHSYIENLKSTKEYVYFIYLQDIYYNINIFKNKGRLYISNNGLCNDKLKDNNNNNNINSNNFGNSYNAYTKKKSFYHSFNDLNEAKEIRKKRKNEKSEKNIVEYLLCNIINPNENYHIQNIYNHNLNNNVSIEIHKKNDSVMYHYNNEKKTKTSKMTTDIKLKQINNVYIKYVPYKNKIITLACPNKYYPTLYRYFSSHTNKKEDAEENDKNKNININNVDNRYKEDFMYGCENKNDSEKHKKTTNNNFGDEFEKLKVKELDKILNKLEMLYDNKNNKMNINVKILGYIFKNFLLKNKELKRKIFCSLFFLLCSKMAIIYTPILLSTFIENVNLQKSLSNNIDIYSTNKSSVLLLCAYVFSRVLSSTMNELRNSVFSNISQKISTFVSKLFFYKIHNLNLTYILSKKNGELSFIFNRGCKSITNLLNVMVFQIIPIIIEFILYLYILTYKIHYTVSLVTCFNMFLYVLFTTLITKRRTIIRKHMNKAEQNTFNIFLDSIQNVEQVKYYTNEIHELKKFIKEQKKYEKEAINVQKSLSFLNFGQQIILNTNLFLCMYLTYLNIANDIFPFSYLILVNTLLFQLAMPLNMFGTIYRETKLSLVDIESMIKILVKKIKSPDYGNQMLIKNGNIKFENVYFKYPLNEDINGLEQNYQAKEKDPNIINNINNINNINNINNINNINSINNIYTFESNVKNISSTNMITSSINKLKKWYLDKVKDNKKNVQYNNNDVKKTNPNITKNLNKEIKENINTHLKNHKIINNSPNYNNNNYLFQNFTCNIENGEKVAIIGKSGSGKSSLIKLLLKFYEVNSGNIYIDNKNIDDIDLYTLRKNISVVPQDTILFNNTISYNIKYGNFQCTDKQMIQASIKAELHDKIMKMENKYDTIVGERGTKLSIGEKQRICIARCFLKDSKIIVLDEHASNLDNENKKAIEKALTKLCMGKTTFIITHVMENLKHMDKIIFFCGKNIYVGSHKNLMDDNHFYREYYDSKNNKML" }, { "InterPro": [ { "InterPro-ID": "IPR001046", "InterPro-Name": "NRAMP_fam", "InterPro-Type": "FAMILY", "Beg": 178, "End": 671 }, { "InterPro-ID": "IPR001046", "InterPro-Name": "NRAMP_fam", "InterPro-Type": "FAMILY", "Beg": 274, "End": 618 }, { "InterPro-ID": "IPR001046", "InterPro-Name": "NRAMP_fam", "InterPro-Type": "FAMILY", "Beg": 588, "End": 607 }, { "InterPro-ID": "IPR001046", "InterPro-Name": "NRAMP_fam", "InterPro-Type": "FAMILY", "Beg": 424, "End": 447 }, { "InterPro-ID": "IPR001046", "InterPro-Name": "NRAMP_fam", "InterPro-Type": "FAMILY", "Beg": 322, "End": 348 }, { "InterPro-ID": "IPR001046", "InterPro-Name": "NRAMP_fam", "InterPro-Type": "FAMILY", "Beg": 529, "End": 548 }, { "InterPro-ID": "IPR001046", "InterPro-Name": "NRAMP_fam", "InterPro-Type": "FAMILY", "Beg": 375, "End": 396 } ], "response#1": "MEKDFTERSTKGQRKLANGVVENIESKLKNHLDNNNVINKSVNYEDVMCSNVKLSVHDDEYDIKNIKKDVCNLSKLSEERLSNNISLKDNNKVVKNPEIDTKTARQQYKKRLNSTQSTMNIEGNINNEKDDIIEDYDDGLIRNMDYEMSIVKNKRNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNSNNVDNRKRNKNEECYDESYCISDNLDEITSYRNKLSLYNKLRMCFNYFGPGWIVAIAYLDPGNLCSNLNVGLIRSPDPTLEKDYSGYYLLWIMVYGHMLGFIFQVLSMRLGHVTGLDLASLCSKEFDRTTSTIIYVLVQIAIWGAHIQAIIGTFIALNLIFGISVKVAIFYTLFEAIIYSFLENKSLGLLENVLSFLVGILAVSFFVNVFMTPINFKELAISILYPRIPKGKEIDALALLGSIISAHIFYLHTNLTAKKKSVICNDLSLRRYNTLGTIESGGSLFLSCLTNCIIVLTFAEVNLKSFERRDQYNLFTAYEVMRKSFGKISMYIWSFGLLSSGNNSSFMCEYASKSVVEGFLNKKINTFVRVFTFRLMLFSLLYMFLTLNKYTLDQLTNFINVIQVLLLPMATIPLYRFSIHENVLGEFRLKKFPKFAVFLIIIAIIISNVLLTFLDFVHKETSLITIFFLVIFSFLYFGFIIYFFNIPIKKNYIQRN", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to NRAMP_fam, NRAMP_fam, NRAMP_fam, NRAMP_fam, NRAMP_fam, NRAMP_fam, NRAMP_fam that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MEKDFTERSTKGQRKLANGVVENIESKLKNHLDNNNVINKSVNYEDVMCSNVKLSVHDDEYDIKNIKKDVCNLSKLSEERLSNNISLKDNNKVVKNPEIDTKTARQQYKKRLNSTQSTMNIEGNINNEKDDIIEDYDDGLIRNMDYEMSIVKNKRNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNSNNVDNRKRNKNEECYDESYCISDNLDEITSYRNKLSLYNKLRMCFNYFGPGWIVAIAYLDPGNLCSNLNVGLIRSPDPTLEKDYSGYYLLWIMVYGHMLGFIFQVLSMRLGHVTGLDLASLCSKEFDRTTSTIIYVLVQIAIWGAHIQAIIGTFIALNLIFGISVKVAIFYTLFEAIIYSFLENKSLGLLENVLSFLVGILAVSFFVNVFMTPINFKELAISILYPRIPKGKEIDALALLGSIISAHIFYLHTNLTAKKKSVICNDLSLRRYNTLGTIESGGSLFLSCLTNCIIVLTFAEVNLKSFERRDQYNLFTAYEVMRKSFGKISMYIWSFGLLSSGNNSSFMCEYASKSVVEGFLNKKINTFVRVFTFRLMLFSLLYMFLTLNKYTLDQLTNFINVIQVLLLPMATIPLYRFSIHENVLGEFRLKKFPKFAVFLIIIAIIISNVLLTFLDFVHKETSLITIFFLVIFSFLYFGFIIYFFNIPIKKNYIQRN" }, { "InterPro": [ { "InterPro-ID": "IPR016047", "InterPro-Name": "Peptidase_M23", "InterPro-Type": "DOMAIN", "Beg": 298, "End": 392 }, { "InterPro-ID": "IPR011055", "InterPro-Name": "Dup_hybrid_motif", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 147, "End": 393 }, { "InterPro-ID": "IPR045834", "InterPro-Name": "Csd3_N2", "InterPro-Type": "DOMAIN", "Beg": 169, "End": 286 }, { "InterPro-ID": "IPR013731", "InterPro-Name": "OapA_N", "InterPro-Type": "DOMAIN", "Beg": 4, "End": 31 }, { "InterPro-ID": "IPR011055", "InterPro-Name": "Dup_hybrid_motif", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 269, "End": 399 }, { "InterPro-ID": "IPR050570", "InterPro-Name": "Cell_wall_metabolism_enzyme", "InterPro-Type": "FAMILY", "Beg": 28, "End": 394 } ], "response#1": "MLSLFNRLPWLHRVLITAFSAIIVFAIFFLPNSEDLRKPDAQREVGRHYPVTLDNQLVSTPEEEVIAPPSVMLRWETYQVANGESAALLFQRAGLSSRVLYELTSSNSDINNQLSKLMPKDELKFGFDKDNQLVQLKRTISPYETFVVTRSDSGFTSEFDKKEVTFQLNYAEAKITSNFWNAGVTAGLSANQIIELANMFGWDIDFALDIREGDQFKLLYQEKIVEGSVIGRGNIIAATFINQGSTFTAILDDNTGNYYDQNGRAMKKAFLRSPLDFRRVSSNFNPRRLHPVTGQIKAHRGTDYVAPVGTPIWAAGDGVVEKSSYNQFNGNYVYIRHSNTYITKYLHLQRRLVKTGERVKQGQTIGTLGGTGRVTGPHLHYEFLVNGIHKNPRTVELPQAQSLTGKAKETFIANAKQRMEKLERYSQLLYANQ", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Peptidase_M23, Csd3_N2, OapA_N that are essential for its biological function; 2. The protein should belong to Cell_wall_metabolism_enzyme that shares evolutionary origin and functional similarity; 3. The protein should be classified within Dup_hybrid_motif, Dup_hybrid_motif sharing conserved structural features. The designed protein sequence is ", "reference": "MLSLFNRLPWLHRVLITAFSAIIVFAIFFLPNSEDLRKPDAQREVGRHYPVTLDNQLVSTPEEEVIAPPSVMLRWETYQVANGESAALLFQRAGLSSRVLYELTSSNSDINNQLSKLMPKDELKFGFDKDNQLVQLKRTISPYETFVVTRSDSGFTSEFDKKEVTFQLNYAEAKITSNFWNAGVTAGLSANQIIELANMFGWDIDFALDIREGDQFKLLYQEKIVEGSVIGRGNIIAATFINQGSTFTAILDDNTGNYYDQNGRAMKKAFLRSPLDFRRVSSNFNPRRLHPVTGQIKAHRGTDYVAPVGTPIWAAGDGVVEKSSYNQFNGNYVYIRHSNTYITKYLHLQRRLVKTGERVKQGQTIGTLGGTGRVTGPHLHYEFLVNGIHKNPRTVELPQAQSLTGKAKETFIANAKQRMEKLERYSQLLYANQ" }, { "InterPro": [ { "InterPro-ID": "IPR002347", "InterPro-Name": "SDR_fam", "InterPro-Type": "FAMILY", "Beg": 16, "End": 249 }, { "InterPro-ID": "IPR036291", "InterPro-Name": "NAD(P)-bd_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 9, "End": 249 }, { "InterPro-ID": "IPR002347", "InterPro-Name": "SDR_fam", "InterPro-Type": "FAMILY", "Beg": 134, "End": 142 }, { "InterPro-ID": "IPR002347", "InterPro-Name": "SDR_fam", "InterPro-Type": "FAMILY", "Beg": 154, "End": 173 }, { "InterPro-ID": "IPR002347", "InterPro-Name": "SDR_fam", "InterPro-Type": "FAMILY", "Beg": 81, "End": 92 }, { "InterPro-ID": "IPR002347", "InterPro-Name": "SDR_fam", "InterPro-Type": "FAMILY", "Beg": 214, "End": 234 }, { "InterPro-ID": "IPR002347", "InterPro-Name": "SDR_fam", "InterPro-Type": "FAMILY", "Beg": 175, "End": 192 }, { "InterPro-ID": "IPR002347", "InterPro-Name": "SDR_fam", "InterPro-Type": "FAMILY", "Beg": 128, "End": 144 }, { "InterPro-ID": "IPR002347", "InterPro-Name": "SDR_fam", "InterPro-Type": "FAMILY", "Beg": 11, "End": 28 } ], "response#1": "MASGARYAGKVVVVTGAARGIGAGIARAFVDSGAQVVICDKDERGGRALEQELRGAVFIRCDVTREEDVRALLSDTVHRFGRLDCVVNNAGSHPPLQPLEETTAQGFRELLELNLLGTYTLCKLAFPHLRRSRGNIINISTLVGAVGQLQGVPYAATKGAVTALTKALALDESQYGVRVNCISPGNIWTPLWQELAALAPDPRAAIREGAMAQPLGRMGQPAEVGAAAVFLASEASFCTGLELFVTGGAELGSGPENFFRSLGLCVVPEDVPPPTSRPRICSYK", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to SDR_fam, SDR_fam, SDR_fam, SDR_fam, SDR_fam, SDR_fam, SDR_fam, SDR_fam that shares evolutionary origin and functional similarity; 2. The protein should be classified within NAD(P)-bd_dom_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MASGARYAGKVVVVTGAARGIGAGIARAFVDSGAQVVICDKDERGGRALEQELRGAVFIRCDVTREEDVRALLSDTVHRFGRLDCVVNNAGSHPPLQPLEETTAQGFRELLELNLLGTYTLCKLAFPHLRRSRGNIINISTLVGAVGQLQGVPYAATKGAVTALTKALALDESQYGVRVNCISPGNIWTPLWQELAALAPDPRAAIREGAMAQPLGRMGQPAEVGAAAVFLASEASFCTGLELFVTGGAELGSGPENFFRSLGLCVVPEDVPPPTSRPRICSYK" }, { "InterPro": [ { "InterPro-ID": "IPR011141", "InterPro-Name": "Polyketide_synthase_type-III", "InterPro-Type": "FAMILY", "Beg": 17, "End": 396 }, { "InterPro-ID": "IPR016039", "InterPro-Name": "Thiolase-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 240, "End": 395 }, { "InterPro-ID": "IPR016039", "InterPro-Name": "Thiolase-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 2, "End": 240 }, { "InterPro-ID": "IPR011141", "InterPro-Name": "Polyketide_synthase_type-III", "InterPro-Type": "FAMILY", "Beg": 9, "End": 399 }, { "InterPro-ID": "IPR012328", "InterPro-Name": "Chalcone/stilbene_synt_C", "InterPro-Type": "DOMAIN", "Beg": 243, "End": 397 }, { "InterPro-ID": "IPR001099", "InterPro-Name": "Chalcone/stilbene_synt_N", "InterPro-Type": "DOMAIN", "Beg": 15, "End": 234 }, { "InterPro-ID": "IPR016039", "InterPro-Name": "Thiolase-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 241, "End": 396 }, { "InterPro-ID": "IPR016039", "InterPro-Name": "Thiolase-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 19, "End": 237 } ], "response#1": "MVSTNAGGIASKQASSMAPNPGKATILALGHAFPQQLVMQDYVVDGFMRNTNCDDPELKEKLTRLCKTTTVKTRYVVMSEEILKSYPELAQEGQPTMKQRLDISNKAVTQMATEASLACVRSWGGALSEITHLVYVSSSEARFPGGDLHLARALGLSPDVRRVMLAFTGCSGGVAGLRVAKGLAESCPGARVLLATSETTIVGFRPPSPDRPYDLVGVALFGDGAGAAVVGADPTPVERPLFELHSALQRFLPDTDKTIDGRLTEEGIKFQLGRELPHIIEANVEAFCQKLMQEHPQAADKLTYGDMFWAVHPGGPAILTKMEGRLGLDGGKLRASRSALRDFGNASSNTIVYVLENMVEETRQRREEAAEEEDCEWGLILAFGPGITFEGILARNLQARARARD", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Chalcone/stilbene_synt_C, Chalcone/stilbene_synt_N that are essential for its biological function; 2. The protein should belong to Polyketide_synthase_type-III, Polyketide_synthase_type-III that shares evolutionary origin and functional similarity; 3. The protein should be classified within Thiolase-like, Thiolase-like, Thiolase-like, Thiolase-like sharing conserved structural features. The designed protein sequence is ", "reference": "MVSTNAGGIASKQASSMAPNPGKATILALGHAFPQQLVMQDYVVDGFMRNTNCDDPELKEKLTRLCKTTTVKTRYVVMSEEILKSYPELAQEGQPTMKQRLDISNKAVTQMATEASLACVRSWGGALSEITHLVYVSSSEARFPGGDLHLARALGLSPDVRRVMLAFTGCSGGVAGLRVAKGLAESCPGARVLLATSETTIVGFRPPSPDRPYDLVGVALFGDGAGAAVVGADPTPVERPLFELHSALQRFLPDTDKTIDGRLTEEGIKFQLGRELPHIIEANVEAFCQKLMQEHPQAADKLTYGDMFWAVHPGGPAILTKMEGRLGLDGGKLRASRSALRDFGNASSNTIVYVLENMVEETRQRREEAAEEEDCEWGLILAFGPGITFEGILARNLQARARARD" }, { "InterPro": [ { "InterPro-ID": "IPR002021", "InterPro-Name": "Paramyx_ncap", "InterPro-Type": "FAMILY", "Beg": 30, "End": 403 } ], "response#1": "MSSVLKAFERFTIEQELQDRGEEGSIPPETLKSAVKVFVINTPNPTTRYQMLNFCLRIICSQNARASHRVGALITLFSLPSAGMQNHIRLADRSPEAQIERCEIDGFEPGTYRLIPNARANLTANEIAAYALLADDLPPTINNGTPYVHADVEGQPCDEIEQFLDRCYSVLIQAWVMVCKCMTAYDQPAGSADRRFAKYQQQGRLEARYMLQPEAQRLIQTAIRKSLVVRQYLTFELQLARRQGLLSNRYYAMVGDIGKYIENSGLTAFFLTLKYALGTKWSPLSLAAFTGELTKLRSLMMLYRDLGEQARYLALLEAPQIMDFAPGGYPLIFSYAMGVGTVLDVQMRNYTYARPFLNGYYFQIGVETARRQQGTVDNRVADDLGLTPEQRTEVTQLVDRLARGRGAGIPGGPVNPFVPPVQQQQPAAVYEDIPALEESDDDGDEDGGAGFQNGAQAPAVRQGGQNDFRAQPLQDPIQAQLFMPLYPQVSNIPNHQNHQINRIGGMEHQDLLRYNENGDSQQDARGEHGNTFPNNPNQNAQSQVGDWDE", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Paramyx_ncap that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MSSVLKAFERFTIEQELQDRGEEGSIPPETLKSAVKVFVINTPNPTTRYQMLNFCLRIICSQNARASHRVGALITLFSLPSAGMQNHIRLADRSPEAQIERCEIDGFEPGTYRLIPNARANLTANEIAAYALLADDLPPTINNGTPYVHADVEGQPCDEIEQFLDRCYSVLIQAWVMVCKCMTAYDQPAGSADRRFAKYQQQGRLEARYMLQPEAQRLIQTAIRKSLVVRQYLTFELQLARRQGLLSNRYYAMVGDIGKYIENSGLTAFFLTLKYALGTKWSPLSLAAFTGELTKLRSLMMLYRDLGEQARYLALLEAPQIMDFAPGGYPLIFSYAMGVGTVLDVQMRNYTYARPFLNGYYFQIGVETARRQQGTVDNRVADDLGLTPEQRTEVTQLVDRLARGRGAGIPGGPVNPFVPPVQQQQPAAVYEDIPALEESDDDGDEDGGAGFQNGAQAPAVRQGGQNDFRAQPLQDPIQAQLFMPLYPQVSNIPNHQNHQINRIGGMEHQDLLRYNENGDSQQDARGEHGNTFPNNPNQNAQSQVGDWDE" }, { "InterPro": [ { "InterPro-ID": "IPR008922", "InterPro-Name": "Di-copper_centre_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 159, "End": 435 }, { "InterPro-ID": "IPR036697", "InterPro-Name": "Hemocyanin_N_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 30, "End": 158 }, { "InterPro-ID": "IPR000896", "InterPro-Name": "Hemocyanin/hexamerin_mid_dom", "InterPro-Type": "DOMAIN", "Beg": 159, "End": 428 }, { "InterPro-ID": "IPR037020", "InterPro-Name": "Hemocyanin_C_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 436, "End": 682 }, { "InterPro-ID": "IPR036697", "InterPro-Name": "Hemocyanin_N_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 56, "End": 158 }, { "InterPro-ID": "IPR014756", "InterPro-Name": "Ig_E-set", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 436, "End": 674 }, { "InterPro-ID": "IPR005204", "InterPro-Name": "Hemocyanin_N", "InterPro-Type": "DOMAIN", "Beg": 32, "End": 153 }, { "InterPro-ID": "IPR013788", "InterPro-Name": "Hemocyanin/hexamerin", "InterPro-Type": "FAMILY", "Beg": 410, "End": 418 }, { "InterPro-ID": "IPR013788", "InterPro-Name": "Hemocyanin/hexamerin", "InterPro-Type": "FAMILY", "Beg": 413, "End": 428 }, { "InterPro-ID": "IPR013788", "InterPro-Name": "Hemocyanin/hexamerin", "InterPro-Type": "FAMILY", "Beg": 218, "End": 231 }, { "InterPro-ID": "IPR013788", "InterPro-Name": "Hemocyanin/hexamerin", "InterPro-Type": "FAMILY", "Beg": 264, "End": 276 }, { "InterPro-ID": "IPR005203", "InterPro-Name": "Hemocyanin_C", "InterPro-Type": "DOMAIN", "Beg": 437, "End": 673 }, { "InterPro-ID": "IPR013788", "InterPro-Name": "Hemocyanin/hexamerin", "InterPro-Type": "FAMILY", "Beg": 10, "End": 676 } ], "response#1": "MIVIMKAGFLFLASLCLLVQAVPNKVADKTYVTRQKNIYELFWHVDQPTVYHPELYQKARTFNLVENLDNYNDKEAVNEFMQLLKHGMLPRGQVFTMMNKEMRHQAVVLFRLLYSAKTFDVFYNTAVWARFNVNEQMYLYALSVAVIHRPDTKLMKLPPMYEVMPHLYFNDEVMQKAYNIAMGDTADMKKTYNNIDYYLLAANYTGWYLTKHNVPEQRLNYFTEDVGLNHFYFMLNHNYPPFMLSNSLNFPQIRGEFYFFLHKQVLNRYYLERLSNDMGEVSYVSLDHPIPTGYYPTMRFRNGLAFPQRETGATVPLHMQKYVQMIHDLHTRISTAIDLGYVVDSYGNHVKLYTKQGLNVLGNIVQGNGDSVNVQLYGQLDLLVRKVLGFGYESNVKYQVVPSALQMWSTSLRDPVFFSIYKTILDYYHKYKENLPKYTTEELNFPGVSIESVTVDKLITYFDHFESMLNNGVSIQSHAKAKNTMIKARQYRLNHKPFTYHIVVNSDKNVKGMVRIFLGPKYDEFGHEVDLVHNYMNFMQMDEFVVNLKSGSNTIERNSHESVFVVPDEVPSDVLYNRLVVSEDGSETFKYSSQPYGFPERLLLPKGKKEGMPYNVLVVVSPFDDSNVVQIDSPVWGRHIYDGRAMGFPLDKPVDPLLLVLSNIHVKEVLVHHREMEELNVAL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Hemocyanin/hexamerin_mid_dom, Hemocyanin_N, Hemocyanin_C that are essential for its biological function; 2. The protein should belong to Hemocyanin/hexamerin, Hemocyanin/hexamerin, Hemocyanin/hexamerin, Hemocyanin/hexamerin, Hemocyanin/hexamerin that shares evolutionary origin and functional similarity; 3. The protein should be classified within Di-copper_centre_dom_sf, Hemocyanin_N_sf, Hemocyanin_C_sf, Hemocyanin_N_sf, Ig_E-set sharing conserved structural features. The designed protein sequence is ", "reference": "MIVIMKAGFLFLASLCLLVQAVPNKVADKTYVTRQKNIYELFWHVDQPTVYHPELYQKARTFNLVENLDNYNDKEAVNEFMQLLKHGMLPRGQVFTMMNKEMRHQAVVLFRLLYSAKTFDVFYNTAVWARFNVNEQMYLYALSVAVIHRPDTKLMKLPPMYEVMPHLYFNDEVMQKAYNIAMGDTADMKKTYNNIDYYLLAANYTGWYLTKHNVPEQRLNYFTEDVGLNHFYFMLNHNYPPFMLSNSLNFPQIRGEFYFFLHKQVLNRYYLERLSNDMGEVSYVSLDHPIPTGYYPTMRFRNGLAFPQRETGATVPLHMQKYVQMIHDLHTRISTAIDLGYVVDSYGNHVKLYTKQGLNVLGNIVQGNGDSVNVQLYGQLDLLVRKVLGFGYESNVKYQVVPSALQMWSTSLRDPVFFSIYKTILDYYHKYKENLPKYTTEELNFPGVSIESVTVDKLITYFDHFESMLNNGVSIQSHAKAKNTMIKARQYRLNHKPFTYHIVVNSDKNVKGMVRIFLGPKYDEFGHEVDLVHNYMNFMQMDEFVVNLKSGSNTIERNSHESVFVVPDEVPSDVLYNRLVVSEDGSETFKYSSQPYGFPERLLLPKGKKEGMPYNVLVVVSPFDDSNVVQIDSPVWGRHIYDGRAMGFPLDKPVDPLLLVLSNIHVKEVLVHHREMEELNVAL" }, { "InterPro": [ { "InterPro-ID": "IPR050880", "InterPro-Name": "PriA_helicase", "InterPro-Type": "FAMILY", "Beg": 1, "End": 728 }, { "InterPro-ID": "IPR001650", "InterPro-Name": "Helicase_C-like", "InterPro-Type": "DOMAIN", "Beg": 492, "End": 589 }, { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 216, "End": 621 }, { "InterPro-ID": "IPR042115", "InterPro-Name": "PriA_3primeBD_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 4, "End": 109 }, { "InterPro-ID": "IPR041222", "InterPro-Name": "PriA_3primeBD", "InterPro-Type": "DOMAIN", "Beg": 5, "End": 99 }, { "InterPro-ID": "IPR005259", "InterPro-Name": "PriA", "InterPro-Type": "FAMILY", "Beg": 7, "End": 729 }, { "InterPro-ID": "IPR011545", "InterPro-Name": "DEAD/DEAH_box_helicase_dom", "InterPro-Type": "DOMAIN", "Beg": 201, "End": 361 }, { "InterPro-ID": "IPR041236", "InterPro-Name": "PriA_C", "InterPro-Type": "DOMAIN", "Beg": 632, "End": 726 }, { "InterPro-ID": "IPR005259", "InterPro-Name": "PriA", "InterPro-Type": "FAMILY", "Beg": 219, "End": 726 }, { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 451, "End": 625 }, { "InterPro-ID": "IPR001650", "InterPro-Name": "Helicase_C-like", "InterPro-Type": "DOMAIN", "Beg": 504, "End": 588 }, { "InterPro-ID": "IPR040498", "InterPro-Name": "PriA_CRR", "InterPro-Type": "DOMAIN", "Beg": 445, "End": 471 }, { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 194, "End": 379 }, { "InterPro-ID": "IPR014001", "InterPro-Name": "Helicase_ATP-bd", "InterPro-Type": "DOMAIN", "Beg": 193, "End": 389 }, { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 186, "End": 378 }, { "InterPro-ID": "IPR014001", "InterPro-Name": "Helicase_ATP-bd", "InterPro-Type": "DOMAIN", "Beg": 209, "End": 376 }, { "InterPro-ID": "IPR001650", "InterPro-Name": "Helicase_C-like", "InterPro-Type": "DOMAIN", "Beg": 471, "End": 623 } ], "response#1": "MIYHRIAVNVPLSDGLLTYSHSEPLPPGTRVLVPFRNKTVVGMVWETDIAPDMDAARILSVQTVFVEEKPLSQSWRDLLAFTSRYYHYPTGQAVFAALPQGLKETRAVEMPQPPLFYALNEAGRAQTPPPARFNKKAALWDALLSGEMTMAALKQANAQAAKLIEDWAEQGWIETTEAAKPVLRPYRGQASHSEFVLNTGQQKASDEIQTALGRFRSFLLYGITGSGKTEVYFDAMAKVLAQGRQVLFLLPEINLTPQLLKRVENRFADVPTAVLHSRMAAGRRTQDYLRAMLGQAKLVIGTRLAVFTPLPDVGLIVVDEEHDGSFKQDNELRYHARDLAVWRAKQGGCPVVLGSATPSLESWHKAQSGAYRLLQLTERAHASAQLPQVDILNIGRLKLDNGFSPQALQLLKQNFEAGGMSLVYLNRRGFAPALFCGDCGHTFGCPNCSAKMVLHQRARQLRCHHCDHREPIPFKCPDCGNQDLTAVGHGTQRVEETLRAFLPKAAVVRVDRDSTAHKNDWADLYRRIANDEIDILVGTQMLAKGHDFARLNLVIVLNADGSLYSADFRAPERLFAELMQVSGRAGRADKPGKVLIQTQLPEHPVFAAVKAQDYAVFAENELNERQMFAMPPFGFQTAVRADAPRVADAMEFLNAAKETLAPLLPESVSRFGAAPMLMVRLAERERAQVFLESTSRQDLHRAVSLWVQVLQQNRDGKIRWSVDVDPQEA", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Helicase_C-like, PriA_3primeBD, DEAD/DEAH_box_helicase_dom, PriA_C, Helicase_C-like, PriA_CRR, Helicase_ATP-bd, Helicase_ATP-bd, Helicase_C-like that are essential for its biological function; 2. The protein should belong to PriA_helicase, PriA, PriA that shares evolutionary origin and functional similarity; 3. The protein should be classified within P-loop_NTPase, PriA_3primeBD_sf, P-loop_NTPase, P-loop_NTPase, P-loop_NTPase sharing conserved structural features. The designed protein sequence is ", "reference": "MIYHRIAVNVPLSDGLLTYSHSEPLPPGTRVLVPFRNKTVVGMVWETDIAPDMDAARILSVQTVFVEEKPLSQSWRDLLAFTSRYYHYPTGQAVFAALPQGLKETRAVEMPQPPLFYALNEAGRAQTPPPARFNKKAALWDALLSGEMTMAALKQANAQAAKLIEDWAEQGWIETTEAAKPVLRPYRGQASHSEFVLNTGQQKASDEIQTALGRFRSFLLYGITGSGKTEVYFDAMAKVLAQGRQVLFLLPEINLTPQLLKRVENRFADVPTAVLHSRMAAGRRTQDYLRAMLGQAKLVIGTRLAVFTPLPDVGLIVVDEEHDGSFKQDNELRYHARDLAVWRAKQGGCPVVLGSATPSLESWHKAQSGAYRLLQLTERAHASAQLPQVDILNIGRLKLDNGFSPQALQLLKQNFEAGGMSLVYLNRRGFAPALFCGDCGHTFGCPNCSAKMVLHQRARQLRCHHCDHREPIPFKCPDCGNQDLTAVGHGTQRVEETLRAFLPKAAVVRVDRDSTAHKNDWADLYRRIANDEIDILVGTQMLAKGHDFARLNLVIVLNADGSLYSADFRAPERLFAELMQVSGRAGRADKPGKVLIQTQLPEHPVFAAVKAQDYAVFAENELNERQMFAMPPFGFQTAVRADAPRVADAMEFLNAAKETLAPLLPESVSRFGAAPMLMVRLAERERAQVFLESTSRQDLHRAVSLWVQVLQQNRDGKIRWSVDVDPQEA" }, { "InterPro": [ { "InterPro-ID": "IPR000291", "InterPro-Name": "D-Ala_lig_Van_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 103, "End": 114 }, { "InterPro-ID": "IPR011127", "InterPro-Name": "Dala_Dala_lig_N", "InterPro-Type": "DOMAIN", "Beg": 3, "End": 126 }, { "InterPro-ID": "IPR005905", "InterPro-Name": "D_ala_D_ala", "InterPro-Type": "FAMILY", "Beg": 3, "End": 345 }, { "InterPro-ID": "IPR013815", "InterPro-Name": "ATP_grasp_subdomain_1", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 151, "End": 220 }, { "InterPro-ID": "IPR016185", "InterPro-Name": "PreATP-grasp_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 2, "End": 135 }, { "InterPro-ID": "IPR011761", "InterPro-Name": "ATP-grasp", "InterPro-Type": "DOMAIN", "Beg": 141, "End": 343 }, { "InterPro-ID": "IPR011095", "InterPro-Name": "Dala_Dala_lig_C", "InterPro-Type": "DOMAIN", "Beg": 146, "End": 342 }, { "InterPro-ID": "IPR005905", "InterPro-Name": "D_ala_D_ala", "InterPro-Type": "FAMILY", "Beg": 2, "End": 346 }, { "InterPro-ID": "IPR000291", "InterPro-Name": "D-Ala_lig_Van_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 288, "End": 316 }, { "InterPro-ID": "IPR005905", "InterPro-Name": "D_ala_D_ala", "InterPro-Type": "FAMILY", "Beg": 1, "End": 350 } ], "response#1": "MKKIAIIFGGNSPEYTVSLASATSAIEALQSSPYDYDLSLIGIAPDAMDWYLYTGELENIRQDTWLLDTKHKQKIQPLFEGNGFWLSEEQQTLVPDVLFPIMHGKYGEDGSIQGLFELMKLPYVGCGVAGSALCMNKWLLHQAAAAIGVQSAPTILLTNQANQQEQIEAFIQTHGFPVFFKPNEAGSSKGITKVTCVEEIASALKEAFTYCSAVLLQKNIAGVEIGCGILGNDSLTVGACDAISLVDGFFDFEEKYQLISAKITVPAPLPETIETKVKEQAQLLYRSLGLKGLARIDFFVTERGELYLNEINTMPGFTSHSRYPAMMAAVGLSYQELLQKLLVLAKEEVK", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Dala_Dala_lig_N, ATP-grasp, Dala_Dala_lig_C that are essential for its biological function; 2. The protein should belong to D_ala_D_ala, D_ala_D_ala, D_ala_D_ala that shares evolutionary origin and functional similarity; 3. The protein should be classified within ATP_grasp_subdomain_1, PreATP-grasp_dom_sf sharing conserved structural features; 4. The protein should contain D-Ala_lig_Van_CS, D-Ala_lig_Van_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MKKIAIIFGGNSPEYTVSLASATSAIEALQSSPYDYDLSLIGIAPDAMDWYLYTGELENIRQDTWLLDTKHKQKIQPLFEGNGFWLSEEQQTLVPDVLFPIMHGKYGEDGSIQGLFELMKLPYVGCGVAGSALCMNKWLLHQAAAAIGVQSAPTILLTNQANQQEQIEAFIQTHGFPVFFKPNEAGSSKGITKVTCVEEIASALKEAFTYCSAVLLQKNIAGVEIGCGILGNDSLTVGACDAISLVDGFFDFEEKYQLISAKITVPAPLPETIETKVKEQAQLLYRSLGLKGLARIDFFVTERGELYLNEINTMPGFTSHSRYPAMMAAVGLSYQELLQKLLVLAKEEVK" }, { "InterPro": [ { "InterPro-ID": "IPR001663", "InterPro-Name": "Rng_hydr_dOase-A", "InterPro-Type": "FAMILY", "Beg": 19, "End": 402 }, { "InterPro-ID": "IPR015879", "InterPro-Name": "Ring_hydroxy_dOase_asu_C_dom", "InterPro-Type": "DOMAIN", "Beg": 188, "End": 400 }, { "InterPro-ID": "IPR001663", "InterPro-Name": "Rng_hydr_dOase-A", "InterPro-Type": "FAMILY", "Beg": 79, "End": 99 }, { "InterPro-ID": "IPR001663", "InterPro-Name": "Rng_hydr_dOase-A", "InterPro-Type": "FAMILY", "Beg": 100, "End": 120 }, { "InterPro-ID": "IPR001663", "InterPro-Name": "Rng_hydr_dOase-A", "InterPro-Type": "FAMILY", "Beg": 139, "End": 165 }, { "InterPro-ID": "IPR001663", "InterPro-Name": "Rng_hydr_dOase-A", "InterPro-Type": "FAMILY", "Beg": 58, "End": 73 }, { "InterPro-ID": "IPR001663", "InterPro-Name": "Rng_hydr_dOase-A", "InterPro-Type": "FAMILY", "Beg": 176, "End": 198 }, { "InterPro-ID": "IPR001663", "InterPro-Name": "Rng_hydr_dOase-A", "InterPro-Type": "FAMILY", "Beg": 28, "End": 53 }, { "InterPro-ID": "IPR036922", "InterPro-Name": "Rieske_2Fe-2S_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 41, "End": 159 }, { "InterPro-ID": "IPR017941", "InterPro-Name": "Rieske_2Fe-2S", "InterPro-Type": "DOMAIN", "Beg": 43, "End": 126 }, { "InterPro-ID": "IPR036922", "InterPro-Name": "Rieske_2Fe-2S_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 9, "End": 154 }, { "InterPro-ID": "IPR017941", "InterPro-Name": "Rieske_2Fe-2S", "InterPro-Type": "DOMAIN", "Beg": 45, "End": 150 }, { "InterPro-ID": "IPR015881", "InterPro-Name": "Ring-hydroxy_dOase_2Fe2S_BS", "InterPro-Type": "BINDING_SITE", "Beg": 86, "End": 109 } ], "response#1": "MTANPTSIHQRLDRRLSGFSLEQPFYTSPEVYALDLQHIFYKQWLYAVPVCQLAKAGSYTTLRVGAYEVVIVRSRDGEVRAFHNSCRHRGSLICKARQGQVAKLVCPYHQWTYELDGKLIWANDMGPDFDASKYGLKPVNLRNLDGLIYICLSDTPPDFQTFAQLARPYLEVHDLKDAKVAFTSTIIEKGNWKLVWENNRECYHCSSNHPALCRSFPLDPEVAGVQADGGVSKKLQAHFDRCEAAGTPAQFVLAGDGQYRLARMPLQEKALSYTMDGKAAVSRHLGRVAPPDAGTLLMFHYPSTWNHFLPDHSLTFRVMPISPTETEVTTTWLVHKDAVEGVDYDLKRLTEVWIATNDEDREIVETNQQGILSPAYVPGPYSPGQESGVMQFVDWYAASLERALAPRQVAAE", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Ring_hydroxy_dOase_asu_C_dom, Rieske_2Fe-2S, Rieske_2Fe-2S that are essential for its biological function; 2. The protein should belong to Rng_hydr_dOase-A, Rng_hydr_dOase-A, Rng_hydr_dOase-A, Rng_hydr_dOase-A, Rng_hydr_dOase-A, Rng_hydr_dOase-A, Rng_hydr_dOase-A that shares evolutionary origin and functional similarity; 3. The protein should be classified within Rieske_2Fe-2S_sf, Rieske_2Fe-2S_sf sharing conserved structural features; 4. The protein should include a Ring-hydroxy_dOase_2Fe2S_BS that enables ligand binding under diverse conditions. The designed protein sequence is ", "reference": "MTANPTSIHQRLDRRLSGFSLEQPFYTSPEVYALDLQHIFYKQWLYAVPVCQLAKAGSYTTLRVGAYEVVIVRSRDGEVRAFHNSCRHRGSLICKARQGQVAKLVCPYHQWTYELDGKLIWANDMGPDFDASKYGLKPVNLRNLDGLIYICLSDTPPDFQTFAQLARPYLEVHDLKDAKVAFTSTIIEKGNWKLVWENNRECYHCSSNHPALCRSFPLDPEVAGVQADGGVSKKLQAHFDRCEAAGTPAQFVLAGDGQYRLARMPLQEKALSYTMDGKAAVSRHLGRVAPPDAGTLLMFHYPSTWNHFLPDHSLTFRVMPISPTETEVTTTWLVHKDAVEGVDYDLKRLTEVWIATNDEDREIVETNQQGILSPAYVPGPYSPGQESGVMQFVDWYAASLERALAPRQVAAE" }, { "InterPro": [ { "InterPro-ID": "IPR011669", "InterPro-Name": "DgcN-like", "InterPro-Type": "FAMILY", "Beg": 52, "End": 331 }, { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 2, "End": 331 }, { "InterPro-ID": "IPR035086", "InterPro-Name": "DgcN-like_C", "InterPro-Type": "DOMAIN", "Beg": 130, "End": 327 }, { "InterPro-ID": "IPR035402", "InterPro-Name": "DgcN-like_N", "InterPro-Type": "DOMAIN", "Beg": 46, "End": 124 }, { "InterPro-ID": "IPR011669", "InterPro-Name": "DgcN-like", "InterPro-Type": "FAMILY", "Beg": 2, "End": 333 }, { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 128, "End": 332 } ], "response#1": "MIETPYLLFLGDAPDMLAAKVAIGIRDWRPDHAVGQISLPGCGANLGLTEMTLEEAKAAGAKTLVIGVANRGGKISQEWKKVLVQALEEGFDLASGLHNLLRDEPDLAAVAEATGRTLHDVRVPSVQYPIADGVKRRGKRCLAVGTDCSVGKMYTALAMDAEMQARGIKSTFRATGQTGILITGDGVPLDAVIADFMAGSIEYLTPDNDDDHWDLIEGQGSLFHVSYSGVTMALVHGGQPDALILCHEPTRTHMRGLPDYDVPSLEELRDVALPLAQRANKDCKIVGISVNTQHLGEEEAVAYLKEVEGRMGLPAVDPYRHGAGRLVDALAAV", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more DgcN-like_C, DgcN-like_N that are essential for its biological function; 2. The protein should belong to DgcN-like, DgcN-like that shares evolutionary origin and functional similarity; 3. The protein should be classified within P-loop_NTPase, P-loop_NTPase sharing conserved structural features. The designed protein sequence is ", "reference": "MIETPYLLFLGDAPDMLAAKVAIGIRDWRPDHAVGQISLPGCGANLGLTEMTLEEAKAAGAKTLVIGVANRGGKISQEWKKVLVQALEEGFDLASGLHNLLRDEPDLAAVAEATGRTLHDVRVPSVQYPIADGVKRRGKRCLAVGTDCSVGKMYTALAMDAEMQARGIKSTFRATGQTGILITGDGVPLDAVIADFMAGSIEYLTPDNDDDHWDLIEGQGSLFHVSYSGVTMALVHGGQPDALILCHEPTRTHMRGLPDYDVPSLEELRDVALPLAQRANKDCKIVGISVNTQHLGEEEAVAYLKEVEGRMGLPAVDPYRHGAGRLVDALAAV" }, { "InterPro": [ { "InterPro-ID": "IPR007941", "InterPro-Name": "DUF726", "InterPro-Type": "FAMILY", "Beg": 3, "End": 645 }, { "InterPro-ID": "IPR029058", "InterPro-Name": "AB_hydrolase_fold", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 497, "End": 587 }, { "InterPro-ID": "IPR007941", "InterPro-Name": "DUF726", "InterPro-Type": "FAMILY", "Beg": 290, "End": 638 }, { "InterPro-ID": "IPR029058", "InterPro-Name": "AB_hydrolase_fold", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 402, "End": 638 } ], "response#1": "MATTLTPTQRYAAGALLALALRQAQIHQSVLLGAHHHHDDDDEEQGRTSTSSGGGGGSSSSSSNSGAGADADLWTHDSHGLLRPVFRFLEIDPKAWSGLEETAASSEAKHHIGAFLRIIFEEDGESSSDRSVQELALAKGVDVMVMSLGNDSEVGNTIKGGDQDALPSSSGTDKSPGESSHDDQLGINKLTLDDIPANNHRKMALLFALLSACVADKPVSQEEEDRKSTRFRKGYDARHRVALRLLSTWLDVKWIKMEAIEVMVACSAMAAAKEQEQSQESASPKSKWEKWKRGGIIGAAALTGGALLAITGGLAAPAIAAGFGALAPTLGTLVPVIGASGFAAMATAAGSVAGSVAVAASFGAAGAGLTGSKMARRIGSVKEFEFKPIGENHNQGRLAVGILISGFAFDEDDFCRPWEGWQDNLERYILQWESKHIIAVSTAIQDWLTSRLAMELMKQGAMRTVLSGLLAAFAWPATLLAATDFIDSKWSVAIDRSDKAGKMLAEVLLKGLQGNRPVTLIGFSLGARVIFKCLQELALSSDNEGLVERVVLLGAPVSVKGERWEAARKMVAGRFVNVYSTDDWILGVTFRASLLTQGLAGIQAIDVPGVENVDVTELVDGHSSYLSAAQQILEHLELNTYYPVFVPLSAANEETDGTVAQ", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to DUF726, DUF726 that shares evolutionary origin and functional similarity; 2. The protein should be classified within AB_hydrolase_fold, AB_hydrolase_fold sharing conserved structural features. The designed protein sequence is ", "reference": "MATTLTPTQRYAAGALLALALRQAQIHQSVLLGAHHHHDDDDEEQGRTSTSSGGGGGSSSSSSNSGAGADADLWTHDSHGLLRPVFRFLEIDPKAWSGLEETAASSEAKHHIGAFLRIIFEEDGESSSDRSVQELALAKGVDVMVMSLGNDSEVGNTIKGGDQDALPSSSGTDKSPGESSHDDQLGINKLTLDDIPANNHRKMALLFALLSACVADKPVSQEEEDRKSTRFRKGYDARHRVALRLLSTWLDVKWIKMEAIEVMVACSAMAAAKEQEQSQESASPKSKWEKWKRGGIIGAAALTGGALLAITGGLAAPAIAAGFGALAPTLGTLVPVIGASGFAAMATAAGSVAGSVAVAASFGAAGAGLTGSKMARRIGSVKEFEFKPIGENHNQGRLAVGILISGFAFDEDDFCRPWEGWQDNLERYILQWESKHIIAVSTAIQDWLTSRLAMELMKQGAMRTVLSGLLAAFAWPATLLAATDFIDSKWSVAIDRSDKAGKMLAEVLLKGLQGNRPVTLIGFSLGARVIFKCLQELALSSDNEGLVERVVLLGAPVSVKGERWEAARKMVAGRFVNVYSTDDWILGVTFRASLLTQGLAGIQAIDVPGVENVDVTELVDGHSSYLSAAQQILEHLELNTYYPVFVPLSAANEETDGTVAQ" }, { "InterPro": [ { "InterPro-ID": "IPR008604", "InterPro-Name": "MAP7_fam", "InterPro-Type": "FAMILY", "Beg": 422, "End": 587 }, { "InterPro-ID": "IPR051483", "InterPro-Name": "MAP7_domain-containing", "InterPro-Type": "FAMILY", "Beg": 27, "End": 760 } ], "response#1": "MERSGGNGAGARAGAPSEGAAKGSSLLSAKSTEGATGRFSQSTPRPTGMDGFLKSDERQRLAKERREEREKCLAAREQQILEKQKRAKLQYEKQIEERWRKLEEQRQREDQKRAAVEEKRKQKLREEEERLEAMMRRSLERTQQLELKKKCSWAGSAASGPGGRDGESENTPPLPLTLAASIPPSDTGTATAAAESTNACDKLSTSTMNLPKQTEPPMSKHLSSSIVAISYSPDRALRSPLKSSYKSSPTRTTEKKKNTLLSGVGDAGKGAMTGGEPSQMEKVKKGRGATSVSSGGLGSPLRRCEPPENISKRSSSPVKSKVTAKTYPQSPKTVKPTYIGSPVKYYFPPTPSEETLKKKAEKEKSNKEKEGATGRQTTVLPREETLEKPMADKDATEKYVADKHATEKHSATGGKAEHSAGKSTAGTTDAGEAAKILAEKRRQARLQKEQEEQERLEKEEQERLEKEELKRKAEEERLRIEKQEEEKKQQEEEEKRKAEEKAKEKAEEELLSKEEQEKEKQEKEKKEKAMIEKQIQAEKEAAEAKAQDAAKQMRLEREQIMLQIEQERLERKKRIDEIMKRTRKSDASLEVKKEDPKVEIQPLPDVENKIKPVVPNKIEINVLNTCQKVNVSERAAPETFPQDIFSNGLKPVGGPVHPDVLDGKSNSLDDSTEEVQSMDVSPVSKEELISIPEFSPVSEMIPGMSLDQNGTGNARALQDILDFTGPPAFPKKSSENLSLDDCNKNLIEGFNSPGQETTLNTFC", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to MAP7_fam, MAP7_domain-containing that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MERSGGNGAGARAGAPSEGAAKGSSLLSAKSTEGATGRFSQSTPRPTGMDGFLKSDERQRLAKERREEREKCLAAREQQILEKQKRAKLQYEKQIEERWRKLEEQRQREDQKRAAVEEKRKQKLREEEERLEAMMRRSLERTQQLELKKKCSWAGSAASGPGGRDGESENTPPLPLTLAASIPPSDTGTATAAAESTNACDKLSTSTMNLPKQTEPPMSKHLSSSIVAISYSPDRALRSPLKSSYKSSPTRTTEKKKNTLLSGVGDAGKGAMTGGEPSQMEKVKKGRGATSVSSGGLGSPLRRCEPPENISKRSSSPVKSKVTAKTYPQSPKTVKPTYIGSPVKYYFPPTPSEETLKKKAEKEKSNKEKEGATGRQTTVLPREETLEKPMADKDATEKYVADKHATEKHSATGGKAEHSAGKSTAGTTDAGEAAKILAEKRRQARLQKEQEEQERLEKEEQERLEKEELKRKAEEERLRIEKQEEEKKQQEEEEKRKAEEKAKEKAEEELLSKEEQEKEKQEKEKKEKAMIEKQIQAEKEAAEAKAQDAAKQMRLEREQIMLQIEQERLERKKRIDEIMKRTRKSDASLEVKKEDPKVEIQPLPDVENKIKPVVPNKIEINVLNTCQKVNVSERAAPETFPQDIFSNGLKPVGGPVHPDVLDGKSNSLDDSTEEVQSMDVSPVSKEELISIPEFSPVSEMIPGMSLDQNGTGNARALQDILDFTGPPAFPKKSSENLSLDDCNKNLIEGFNSPGQETTLNTFC" }, { "InterPro": [ { "InterPro-ID": "IPR011992", "InterPro-Name": "EF-hand-dom_pair", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 71, "End": 148 }, { "InterPro-ID": "IPR018247", "InterPro-Name": "EF_Hand_1_Ca_BS", "InterPro-Type": "BINDING_SITE", "Beg": 135, "End": 147 }, { "InterPro-ID": "IPR018247", "InterPro-Name": "EF_Hand_1_Ca_BS", "InterPro-Type": "BINDING_SITE", "Beg": 83, "End": 95 }, { "InterPro-ID": "IPR002048", "InterPro-Name": "EF_hand_dom", "InterPro-Type": "DOMAIN", "Beg": 70, "End": 105 }, { "InterPro-ID": "IPR052110", "InterPro-Name": "ER-Golgi_Adhesion_Reg", "InterPro-Type": "FAMILY", "Beg": 4, "End": 150 } ], "response#1": "MTHRRLLWALCVAALLGVVAAQAGDQQQMQPNEADALRKKWSAVEVVRDLGHIKKDLAKMIELEGAGALSQDELYFYYFRMHDFDNNNKLDGQEMMAAMFHTNHHEEDDEHDGKVPLIIPEQDIASYVDSVLRADKNQDGFISYPELRTSDLTNQI", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more EF_hand_dom that are essential for its biological function; 2. The protein should belong to ER-Golgi_Adhesion_Reg that shares evolutionary origin and functional similarity; 3. The protein should be classified within EF-hand-dom_pair sharing conserved structural features; 4. The protein should include a EF_Hand_1_Ca_BS, EF_Hand_1_Ca_BS that enables ligand binding under diverse conditions. The designed protein sequence is ", "reference": "MTHRRLLWALCVAALLGVVAAQAGDQQQMQPNEADALRKKWSAVEVVRDLGHIKKDLAKMIELEGAGALSQDELYFYYFRMHDFDNNNKLDGQEMMAAMFHTNHHEEDDEHDGKVPLIIPEQDIASYVDSVLRADKNQDGFISYPELRTSDLTNQI" }, { "InterPro": [ { "InterPro-ID": "IPR036852", "InterPro-Name": "Peptidase_S8/S53_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 286, "End": 610 }, { "InterPro-ID": "IPR036852", "InterPro-Name": "Peptidase_S8/S53_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 273, "End": 613 }, { "InterPro-ID": "IPR051048", "InterPro-Name": "Peptidase_S8/S53_subtilisin", "InterPro-Type": "FAMILY", "Beg": 182, "End": 605 }, { "InterPro-ID": "IPR000209", "InterPro-Name": "Peptidase_S8/S53_dom", "InterPro-Type": "DOMAIN", "Beg": 310, "End": 588 }, { "InterPro-ID": "IPR023828", "InterPro-Name": "Peptidase_S8_Ser-AS", "InterPro-Type": "ACTIVE_SITE", "Beg": 547, "End": 557 }, { "InterPro-ID": "IPR034204", "InterPro-Name": "PfSUB1-like_cat_dom", "InterPro-Type": "DOMAIN", "Beg": 312, "End": 580 }, { "InterPro-ID": "IPR015500", "InterPro-Name": "Peptidase_S8_subtilisin-rel", "InterPro-Type": "FAMILY", "Beg": 368, "End": 381 }, { "InterPro-ID": "IPR015500", "InterPro-Name": "Peptidase_S8_subtilisin-rel", "InterPro-Type": "FAMILY", "Beg": 546, "End": 562 }, { "InterPro-ID": "IPR015500", "InterPro-Name": "Peptidase_S8_subtilisin-rel", "InterPro-Type": "FAMILY", "Beg": 307, "End": 326 }, { "InterPro-ID": "IPR023827", "InterPro-Name": "Peptidase_S8_Asp-AS", "InterPro-Type": "ACTIVE_SITE", "Beg": 312, "End": 323 }, { "InterPro-ID": "IPR022398", "InterPro-Name": "Peptidase_S8_His-AS", "InterPro-Type": "ACTIVE_SITE", "Beg": 372, "End": 382 }, { "InterPro-ID": "IPR041089", "InterPro-Name": "SUB1_ProdP9", "InterPro-Type": "DOMAIN", "Beg": 123, "End": 202 } ], "response#1": "MVLTRRAALLLCPWVIQLVIKRTLAGDILPNEGKKEKDDVHKIISELRFLQKVETILESSNMSVSDVEADANAYNPDRDAPKEELQKLQDQQETPSKQPNNLRNSPQKRAEKKESPGKNKKSLRLIVSENHATSPSFFEESLLQEDVVSFIQSKGKLSNLKNLKSMIIDLNSDMTDEELAEYISLLERKGALIESDKLVGADDVSLASVKDAVRRGESSVNWGKLRSTMLEVPSGESPPSHAASSGSPFDDDDDLLSEAALHREEAHLAGSKTTKGYKFNDEYRNLQWGLDLARLDETQDLINANRVSVTKICVIDSGIDYNHPDLRNNIDVNVKELHGRKGVDDDSNGVVDDVYGANFVNNSGDPMDDNYHGTHVSGIISAVGNNGIGIVGVDGHSKLVICKALDQHKLGRLGDMFKCIDYCISRQAHMINGSFSFDEYSNIFNASVEHLRSLGILFFVSASNCAHDKLSKPDIAKCDLAVNHRYPPILSKTHNNVIAVANLKRDLDESYSLSVNSFYSNIYCQLAAPGTNIYSTTPMNNYRKLNGTSMASPHVAAIASIVRSINPNLTYLQIVEILRNAIVKLPSLTERVSWGGYVDILRAVNLAIDSKAAPYIKSHSWFRWKQGSRR", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Peptidase_S8/S53_dom, PfSUB1-like_cat_dom, SUB1_ProdP9 that are essential for its biological function; 2. The protein should belong to Peptidase_S8/S53_subtilisin, Peptidase_S8_subtilisin-rel, Peptidase_S8_subtilisin-rel, Peptidase_S8_subtilisin-rel that shares evolutionary origin and functional similarity; 3. The protein should be classified within Peptidase_S8/S53_dom_sf, Peptidase_S8/S53_dom_sf sharing conserved structural features; 4. The protein must have Peptidase_S8_Ser-AS, Peptidase_S8_Asp-AS, Peptidase_S8_His-AS that is conserved among related catalytic enzymes. The designed protein sequence is ", "reference": "MVLTRRAALLLCPWVIQLVIKRTLAGDILPNEGKKEKDDVHKIISELRFLQKVETILESSNMSVSDVEADANAYNPDRDAPKEELQKLQDQQETPSKQPNNLRNSPQKRAEKKESPGKNKKSLRLIVSENHATSPSFFEESLLQEDVVSFIQSKGKLSNLKNLKSMIIDLNSDMTDEELAEYISLLERKGALIESDKLVGADDVSLASVKDAVRRGESSVNWGKLRSTMLEVPSGESPPSHAASSGSPFDDDDDLLSEAALHREEAHLAGSKTTKGYKFNDEYRNLQWGLDLARLDETQDLINANRVSVTKICVIDSGIDYNHPDLRNNIDVNVKELHGRKGVDDDSNGVVDDVYGANFVNNSGDPMDDNYHGTHVSGIISAVGNNGIGIVGVDGHSKLVICKALDQHKLGRLGDMFKCIDYCISRQAHMINGSFSFDEYSNIFNASVEHLRSLGILFFVSASNCAHDKLSKPDIAKCDLAVNHRYPPILSKTHNNVIAVANLKRDLDESYSLSVNSFYSNIYCQLAAPGTNIYSTTPMNNYRKLNGTSMASPHVAAIASIVRSINPNLTYLQIVEILRNAIVKLPSLTERVSWGGYVDILRAVNLAIDSKAAPYIKSHSWFRWKQGSRR" }, { "InterPro": [ { "InterPro-ID": "IPR006047", "InterPro-Name": "Glyco_hydro_13_cat_dom", "InterPro-Type": "DOMAIN", "Beg": 30, "End": 426 }, { "InterPro-ID": "IPR017853", "InterPro-Name": "Glycoside_hydrolase_SF", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 21, "End": 481 }, { "InterPro-ID": "IPR006047", "InterPro-Name": "Glyco_hydro_13_cat_dom", "InterPro-Type": "DOMAIN", "Beg": 30, "End": 487 }, { "InterPro-ID": "IPR045857", "InterPro-Name": "O16G_dom_2", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 122, "End": 195 } ], "response#1": "MKTFAPLLATLLLAGFGSALQWWEHGNFYQVYPRSFKDSDGNGIGDLDGVTEKLQYLKDVGMDGIWLSPIFASPMADFGYDISDFYNIQGEYGDLAAFERLSAKCKELGLRLILDFVPNHTSNQHEYFKKSVQKEDPYTNYYVWHPGVTNEDGTKSPPSNWISVFRGSAWEWNEDRQEYYLHQFLKEQPDLNYRDPALVEEMKNVLKFWLNKGVSGFRIDAVPYLFESVEVENRYVDEPLSRATDDAENPAYLIHNQTMDQPETYDMIYQWRAVLDEFTAKDNQTRIMMTEGYTSIPNVMKFFGEGEQNGAQIPFNFQMISNLRKTSTAADFARYANLWLDNLPAGRRSNWVLGNHDNNRIGSRLGEAKIDLYNIALQTLPDIAVTYYGEEIGMVDQPIPFNETVDPAGLRAGPDDYTLYSRDPARTPMQWNSDKNAGFSSADKTWLPVATNYKQLNVKAQDAAQKSHLKLFKRLTTYRKRQILTHGDLDLRTTDSNLVLYKRKVDKVGYVVVVLNFSDEPQSLAAIKQQFPGADDRLQVVASSKLVTIKDNKWINVADTELPGESAIVLQKLWGPNPVVVYEA", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Glyco_hydro_13_cat_dom, Glyco_hydro_13_cat_dom that are essential for its biological function; 2. The protein should be classified within Glycoside_hydrolase_SF, O16G_dom_2 sharing conserved structural features. The designed protein sequence is ", "reference": "MKTFAPLLATLLLAGFGSALQWWEHGNFYQVYPRSFKDSDGNGIGDLDGVTEKLQYLKDVGMDGIWLSPIFASPMADFGYDISDFYNIQGEYGDLAAFERLSAKCKELGLRLILDFVPNHTSNQHEYFKKSVQKEDPYTNYYVWHPGVTNEDGTKSPPSNWISVFRGSAWEWNEDRQEYYLHQFLKEQPDLNYRDPALVEEMKNVLKFWLNKGVSGFRIDAVPYLFESVEVENRYVDEPLSRATDDAENPAYLIHNQTMDQPETYDMIYQWRAVLDEFTAKDNQTRIMMTEGYTSIPNVMKFFGEGEQNGAQIPFNFQMISNLRKTSTAADFARYANLWLDNLPAGRRSNWVLGNHDNNRIGSRLGEAKIDLYNIALQTLPDIAVTYYGEEIGMVDQPIPFNETVDPAGLRAGPDDYTLYSRDPARTPMQWNSDKNAGFSSADKTWLPVATNYKQLNVKAQDAAQKSHLKLFKRLTTYRKRQILTHGDLDLRTTDSNLVLYKRKVDKVGYVVVVLNFSDEPQSLAAIKQQFPGADDRLQVVASSKLVTIKDNKWINVADTELPGESAIVLQKLWGPNPVVVYEA" }, { "InterPro": [ { "InterPro-ID": "IPR016269", "InterPro-Name": "RNA-dir_pol_paramyxovirus", "InterPro-Type": "FAMILY", "Beg": 1, "End": 2233 }, { "InterPro-ID": "IPR039736", "InterPro-Name": "L_poly_C", "InterPro-Type": "DOMAIN", "Beg": 1245, "End": 2231 }, { "InterPro-ID": "IPR014023", "InterPro-Name": "Mononeg_RNA_pol_cat", "InterPro-Type": "DOMAIN", "Beg": 11, "End": 1123 }, { "InterPro-ID": "IPR014023", "InterPro-Name": "Mononeg_RNA_pol_cat", "InterPro-Type": "DOMAIN", "Beg": 662, "End": 846 }, { "InterPro-ID": "IPR025786", "InterPro-Name": "Mononega_L_MeTrfase", "InterPro-Type": "DOMAIN", "Beg": 1781, "End": 1994 }, { "InterPro-ID": "IPR026890", "InterPro-Name": "Mononeg_mRNAcap", "InterPro-Type": "DOMAIN", "Beg": 1142, "End": 1385 } ], "response#1": "MAGLNEILLPEVHLNSPIVRYKLFYYILHGQLPNDLEPDDLGPLANQNWKAIRAEESQVHARLKQIRVELIARIPSLRWTRSQREIAILIWPRILPILQAYDLRQSMQLPTVWEKLTQSTVNLISDGLERVVLHISNQLTGKPNLFTRSRAGQDAKDYSIPSTRELSQIWFNNEWSGSVKTWLMIKYRMRQLITNQKTGELTDLVTIVDTRSTLCIITPELVALYSNEHKALTYLTFEMVLMVTDMLEGRLNVSSLCTASHYLSPLKKRIEILLTLVDDLALLMGDKVYGVVSSLESFVYAQLQYGDPVVDIKGTFYGFICNEILDLLTEDNIFTEEEANKVLLDLTSQFDNLSPDLTAELLCIMRLWGHPTLTASQAASKVRESMCAPKVLDFQTIMKTLAFFHAILINGYRRSHNGIWPPTTLHGNAPKSLIEMRHDNSELKYEYVLKNWKSISMLRIHKCFDASPDEDLSIFMKDKAISCPKQDWMGVFRRSLIKQRYRDANRPLPQPFNRRLLLNFLEDDRFDPIKELEYVTSGEYLRDPEFCASYSLKEKEIKATGRIFAKMTKRMRSCQVIAESLLANHAGKLMRENGVVLDQLKLTKSLLTMNQIGIISEHSRRSTADNMTLAHSGSNKHRINNSQFKKNKDSKHEMPDDGFEIAACFLTTDLTKYCLNWRYQVIIPFARTLNSMYGVPHLFEWIHLRLMRSTLYVGDPFNPPSDPTQLDLDTALNDDIFIVSPRGGIEGLCQKLWTMISISTIILSATEANTRVMSMVQGDNQAIAITTRVVRSLSHTEKKEQAYKASKLFFERLRANNHGIGHHLKEQETILSSDFFIYSKRVFYKGRILTQALKNVSKMCLTADILGECSQASCSNLATTVMRLTENGVEKDLCYFLNAFMTIRQLCYDLVFPQTKSLSQDITNAYLNHPILISRLCLLPSQLGGLNFFSCSRLFNRNIGDPLVSAIADVKRLIKAGCLDIWVLYNILGRRPGKGKWSTLAADPYTLNIDYLVPSTTFLKKHAQYTLMERSVNPMLRGVFSENAAEEEEELAQYLLDREVVMPRVAHVILAQSSCGRRKQIQGYLDSTRTIIRYSLEVRPLSAKKLNTVIEYNLLYLSYNLEIIEKPNIVQPFLNAINVDTCSIDIARSLRKLSWATLLNGRPIEGLETPDPIELVHGCLIIGSDECEHCSSGDDKFTWFFLPKGIRLDNDPAFNPPIRVPYIGSKTDERRVASMAYIKGASVSLKSALRLAGVYIWAFGDTEESWQDAYELASTRVNLTLEQLQSLTPLPTSANLVHRLDDGTTQLKFTPASSYAFSSFVHISNDCQVLEIDDQVTDSNLIYQQVMITGLALIETWNNPPINFSVYETTLHLHTGSSCCIRPVESCVVNPPLLPVPFINVPQMNKFVYDPEPLSLLEMEKIEDIAYQTRIGGLDQIPLLEKIPLLAHLTAKQMVNSITGLDEATSIVNDAVVQADYTSNWISECCYTYIDSVFVYSGWALLLELSYQMYYLRIQGIQGILDYVYMTLRRIPGMAITGISSTISHPRILRRCINLDVIAPINSPHIASLDYTKLSIDAVMWGTKQVLTNISQGIDYEIVVPSESQLTLSDRVLNLVARKLSLLAIIWANYNYPPKVKGMSPEDKCQALTTHLLQTVEYVEHIQIEKTNIRRMVIEPKLTAYPSNLFYLSRKLLNAIRDSEEGQFLIASYYNSFGYLEPILMESKIFNLSSSESASLTEFDFILNLELSETSLEKYSLPSLLMTAENMDNPFPQPPLHHVLRPLGLSSTSWYKTISVLNYISHMKIYDGAHLYLAEGSGASMSLIETFLPGETIWYNSLFNSGENPPQRNFAPLPTQFIESVPYRLIQAGIAAGSGVVQSFYPLWNGNSDITDLSTKTSVEYIIHKVGADTCALVHVDLEGVPGSMNSMLERAQVHALLITVTVLKPGGLLILKASWEPFNRFSFLLTILWQFFSTIRILRSSYSDPNNHEVYIIATLAVDPTTSSFTTALNRARTLNEQGFSLIPPELVSEYWRRRVEQGQIIQDRIDKVISECVRDQYLADNNIILQAGGTPSTRKWLDLPDYPSFNELQSEMARLITIHLKEVIEILKGQSSDHDTLLFTSYNVGPLGKINTILRLIVERILMYTVRNWCILPTQTRLTLRQSIELGEFRLRDVITPMEILKLSPNRKYLKSALNQSTFNHLMGETSDILLNRAYQKRIWKAIGCVIYCFGLLTPDVEDSERIDIDNDIPDYDIHGDII", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more L_poly_C, Mononeg_RNA_pol_cat, Mononeg_RNA_pol_cat, Mononega_L_MeTrfase, Mononeg_mRNAcap that are essential for its biological function; 2. The protein should belong to RNA-dir_pol_paramyxovirus that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MAGLNEILLPEVHLNSPIVRYKLFYYILHGQLPNDLEPDDLGPLANQNWKAIRAEESQVHARLKQIRVELIARIPSLRWTRSQREIAILIWPRILPILQAYDLRQSMQLPTVWEKLTQSTVNLISDGLERVVLHISNQLTGKPNLFTRSRAGQDAKDYSIPSTRELSQIWFNNEWSGSVKTWLMIKYRMRQLITNQKTGELTDLVTIVDTRSTLCIITPELVALYSNEHKALTYLTFEMVLMVTDMLEGRLNVSSLCTASHYLSPLKKRIEILLTLVDDLALLMGDKVYGVVSSLESFVYAQLQYGDPVVDIKGTFYGFICNEILDLLTEDNIFTEEEANKVLLDLTSQFDNLSPDLTAELLCIMRLWGHPTLTASQAASKVRESMCAPKVLDFQTIMKTLAFFHAILINGYRRSHNGIWPPTTLHGNAPKSLIEMRHDNSELKYEYVLKNWKSISMLRIHKCFDASPDEDLSIFMKDKAISCPKQDWMGVFRRSLIKQRYRDANRPLPQPFNRRLLLNFLEDDRFDPIKELEYVTSGEYLRDPEFCASYSLKEKEIKATGRIFAKMTKRMRSCQVIAESLLANHAGKLMRENGVVLDQLKLTKSLLTMNQIGIISEHSRRSTADNMTLAHSGSNKHRINNSQFKKNKDSKHEMPDDGFEIAACFLTTDLTKYCLNWRYQVIIPFARTLNSMYGVPHLFEWIHLRLMRSTLYVGDPFNPPSDPTQLDLDTALNDDIFIVSPRGGIEGLCQKLWTMISISTIILSATEANTRVMSMVQGDNQAIAITTRVVRSLSHTEKKEQAYKASKLFFERLRANNHGIGHHLKEQETILSSDFFIYSKRVFYKGRILTQALKNVSKMCLTADILGECSQASCSNLATTVMRLTENGVEKDLCYFLNAFMTIRQLCYDLVFPQTKSLSQDITNAYLNHPILISRLCLLPSQLGGLNFFSCSRLFNRNIGDPLVSAIADVKRLIKAGCLDIWVLYNILGRRPGKGKWSTLAADPYTLNIDYLVPSTTFLKKHAQYTLMERSVNPMLRGVFSENAAEEEEELAQYLLDREVVMPRVAHVILAQSSCGRRKQIQGYLDSTRTIIRYSLEVRPLSAKKLNTVIEYNLLYLSYNLEIIEKPNIVQPFLNAINVDTCSIDIARSLRKLSWATLLNGRPIEGLETPDPIELVHGCLIIGSDECEHCSSGDDKFTWFFLPKGIRLDNDPAFNPPIRVPYIGSKTDERRVASMAYIKGASVSLKSALRLAGVYIWAFGDTEESWQDAYELASTRVNLTLEQLQSLTPLPTSANLVHRLDDGTTQLKFTPASSYAFSSFVHISNDCQVLEIDDQVTDSNLIYQQVMITGLALIETWNNPPINFSVYETTLHLHTGSSCCIRPVESCVVNPPLLPVPFINVPQMNKFVYDPEPLSLLEMEKIEDIAYQTRIGGLDQIPLLEKIPLLAHLTAKQMVNSITGLDEATSIVNDAVVQADYTSNWISECCYTYIDSVFVYSGWALLLELSYQMYYLRIQGIQGILDYVYMTLRRIPGMAITGISSTISHPRILRRCINLDVIAPINSPHIASLDYTKLSIDAVMWGTKQVLTNISQGIDYEIVVPSESQLTLSDRVLNLVARKLSLLAIIWANYNYPPKVKGMSPEDKCQALTTHLLQTVEYVEHIQIEKTNIRRMVIEPKLTAYPSNLFYLSRKLLNAIRDSEEGQFLIASYYNSFGYLEPILMESKIFNLSSSESASLTEFDFILNLELSETSLEKYSLPSLLMTAENMDNPFPQPPLHHVLRPLGLSSTSWYKTISVLNYISHMKIYDGAHLYLAEGSGASMSLIETFLPGETIWYNSLFNSGENPPQRNFAPLPTQFIESVPYRLIQAGIAAGSGVVQSFYPLWNGNSDITDLSTKTSVEYIIHKVGADTCALVHVDLEGVPGSMNSMLERAQVHALLITVTVLKPGGLLILKASWEPFNRFSFLLTILWQFFSTIRILRSSYSDPNNHEVYIIATLAVDPTTSSFTTALNRARTLNEQGFSLIPPELVSEYWRRRVEQGQIIQDRIDKVISECVRDQYLADNNIILQAGGTPSTRKWLDLPDYPSFNELQSEMARLITIHLKEVIEILKGQSSDHDTLLFTSYNVGPLGKINTILRLIVERILMYTVRNWCILPTQTRLTLRQSIELGEFRLRDVITPMEILKLSPNRKYLKSALNQSTFNHLMGETSDILLNRAYQKRIWKAIGCVIYCFGLLTPDVEDSERIDIDNDIPDYDIHGDII" }, { "InterPro": [ { "InterPro-ID": "IPR038765", "InterPro-Name": "Papain-like_cys_pep_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 578, "End": 867 }, { "InterPro-ID": "IPR013128", "InterPro-Name": "Peptidase_C1A", "InterPro-Type": "FAMILY", "Beg": 532, "End": 846 }, { "InterPro-ID": "IPR000668", "InterPro-Name": "Peptidase_C1A_C", "InterPro-Type": "DOMAIN", "Beg": 630, "End": 847 }, { "InterPro-ID": "IPR000668", "InterPro-Name": "Peptidase_C1A_C", "InterPro-Type": "DOMAIN", "Beg": 614, "End": 864 } ], "response#1": "MARLSSIVFIICLLLCNNAISDEVIESPSSGGTLSGGGSGTDTVTGTQDGKGKSEGKGNEGGQTDQKGKENPENGQNSDSTGDSSLGSTGSNGSQPAPTTPKEPEPTTPKEPESATPKASEPVTPQKTAETASGKQVSPTPSENPPSKDTPKPESSSEKKVNSALATPPAPEVSKAQEGAGLATQKEQTPSKRAKRSPPPQVNNITDMESYLMKNYDGVKVIGLCGVYFRVQFSPHLLLYGLTTFSIIQIEPFFEGVRIDFEHQHPIRNKCAPGKAFAFISYVKDNILILKWKVFAPPSDLFANDEVSKQILSAVSVTSDAESSVVDVRKYRLPQLDRPFTSIQVYKANPKQGLLETKNYILKNAIPEKCSKISMNCFLNGNVNIENCFKCTLLVQNAKPTDECFQYLPSDMKNNLNEIKVTAQSDEDSKENDLIESIEILLNSFYKADKKAKKLSLITMDDFDDVLRAELFNYCKLLKELDTKKTLENAELGNEIDIFNNLLRLLKTNEEESKHNLYKKLRNTAICLKDVNKWAEKKRGLILPEEVTQDQMAIGQNEEPYDEDPDDRVDLLELFDDNQNENIVDKDGIIDMSIAIKYAKLKSPYFNSSKYCNYEYCDRWQDKTSCISNIDVEEQGNCSLCWLFASKLHLETIRCMRGYGHNRSSALYVANCSKRTAEEICNDGSNPLEFLKILEKNKFLPLESNYPYLWKNVSGKCPNPQNDWTNLWGNTKLLYNNMFGQFIKHRGYIVYSSRFFAKNMNVFIDIIKREIRNKGSVIAYIKTQGVIDYDFNGRYISNICGHNHPDHAVNIIGYGNYISESGEKRSYWLIRNSWGYYWGHEGNFKVDVLGPDNCVHNVIHTAIVFKIDMEPDSDSNNNNAIKNRDQLIDEDNKSYFPQLSSNFYHSLYYNNYEGYEAKNDDENDQNYGNLDVSGQSENHQNDPKNPQPQANSTVTQLGVCPAENQRTADSNPNAQSTPSPNTTVTDTVNSNTANSNTANSNTASANAASIEKKIQILHVLKHIEKYKMTRGFVKYDNLNDTKNDYTCARSYSYDPKNHNECKQFCEENWERCKNHYSPGYCLTTLSGKNKCLFCYV", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Peptidase_C1A_C, Peptidase_C1A_C that are essential for its biological function; 2. The protein should belong to Peptidase_C1A that shares evolutionary origin and functional similarity; 3. The protein should be classified within Papain-like_cys_pep_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MARLSSIVFIICLLLCNNAISDEVIESPSSGGTLSGGGSGTDTVTGTQDGKGKSEGKGNEGGQTDQKGKENPENGQNSDSTGDSSLGSTGSNGSQPAPTTPKEPEPTTPKEPESATPKASEPVTPQKTAETASGKQVSPTPSENPPSKDTPKPESSSEKKVNSALATPPAPEVSKAQEGAGLATQKEQTPSKRAKRSPPPQVNNITDMESYLMKNYDGVKVIGLCGVYFRVQFSPHLLLYGLTTFSIIQIEPFFEGVRIDFEHQHPIRNKCAPGKAFAFISYVKDNILILKWKVFAPPSDLFANDEVSKQILSAVSVTSDAESSVVDVRKYRLPQLDRPFTSIQVYKANPKQGLLETKNYILKNAIPEKCSKISMNCFLNGNVNIENCFKCTLLVQNAKPTDECFQYLPSDMKNNLNEIKVTAQSDEDSKENDLIESIEILLNSFYKADKKAKKLSLITMDDFDDVLRAELFNYCKLLKELDTKKTLENAELGNEIDIFNNLLRLLKTNEEESKHNLYKKLRNTAICLKDVNKWAEKKRGLILPEEVTQDQMAIGQNEEPYDEDPDDRVDLLELFDDNQNENIVDKDGIIDMSIAIKYAKLKSPYFNSSKYCNYEYCDRWQDKTSCISNIDVEEQGNCSLCWLFASKLHLETIRCMRGYGHNRSSALYVANCSKRTAEEICNDGSNPLEFLKILEKNKFLPLESNYPYLWKNVSGKCPNPQNDWTNLWGNTKLLYNNMFGQFIKHRGYIVYSSRFFAKNMNVFIDIIKREIRNKGSVIAYIKTQGVIDYDFNGRYISNICGHNHPDHAVNIIGYGNYISESGEKRSYWLIRNSWGYYWGHEGNFKVDVLGPDNCVHNVIHTAIVFKIDMEPDSDSNNNNAIKNRDQLIDEDNKSYFPQLSSNFYHSLYYNNYEGYEAKNDDENDQNYGNLDVSGQSENHQNDPKNPQPQANSTVTQLGVCPAENQRTADSNPNAQSTPSPNTTVTDTVNSNTANSNTANSNTASANAASIEKKIQILHVLKHIEKYKMTRGFVKYDNLNDTKNDYTCARSYSYDPKNHNECKQFCEENWERCKNHYSPGYCLTTLSGKNKCLFCYV" }, { "InterPro": [ { "InterPro-ID": "IPR011055", "InterPro-Name": "Dup_hybrid_motif", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 145, "End": 391 }, { "InterPro-ID": "IPR045834", "InterPro-Name": "Csd3_N2", "InterPro-Type": "DOMAIN", "Beg": 162, "End": 284 }, { "InterPro-ID": "IPR016047", "InterPro-Name": "Peptidase_M23", "InterPro-Type": "DOMAIN", "Beg": 296, "End": 389 }, { "InterPro-ID": "IPR050570", "InterPro-Name": "Cell_wall_metabolism_enzyme", "InterPro-Type": "FAMILY", "Beg": 26, "End": 392 }, { "InterPro-ID": "IPR007340", "InterPro-Name": "LysM_Opacity-associatedA", "InterPro-Type": "DOMAIN", "Beg": 75, "End": 155 }, { "InterPro-ID": "IPR011055", "InterPro-Name": "Dup_hybrid_motif", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 266, "End": 396 } ], "response#1": "MISKSIILRFSELSMRKKATLVGLPLLAVAAISSSLNSPTRQQRIELSLPESPLVQFSSAEHTVEVVKVGHPDYEYEIKPGDNLSTIFNQLGFAYTELMKVMETDLNYLALDTLRPGNVLRFWKGSDNTLAKMELEFSLVDRAVYTRLNDGSYEFEERKIPGTWKVEPLIGEVDGSFSLSANRAGLGAADVDQIVTLLKDKINFGRDLRRGDRFEVVLSRQLVGEKLTGNSEIQAIKIFNRGKEITAYLHQDGQYYDKNGDSLQRAFQRYPVDSKWRISSNFDPRRLHPVTKRVAPHNGTDFAMPIGTPVYTSGDGVVVMTRNHPYAGNYVVIQHGNTYMTRYLHLSKILVKKGQKVSRGQRIGLSGNTGRVTGPHLHYELIVRGRPVNAMKANIPMASSVPKKEMAQFIAKRKELDQMLARQESMLAAQ", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Csd3_N2, Peptidase_M23, LysM_Opacity-associatedA that are essential for its biological function; 2. The protein should belong to Cell_wall_metabolism_enzyme that shares evolutionary origin and functional similarity; 3. The protein should be classified within Dup_hybrid_motif, Dup_hybrid_motif sharing conserved structural features. The designed protein sequence is ", "reference": "MISKSIILRFSELSMRKKATLVGLPLLAVAAISSSLNSPTRQQRIELSLPESPLVQFSSAEHTVEVVKVGHPDYEYEIKPGDNLSTIFNQLGFAYTELMKVMETDLNYLALDTLRPGNVLRFWKGSDNTLAKMELEFSLVDRAVYTRLNDGSYEFEERKIPGTWKVEPLIGEVDGSFSLSANRAGLGAADVDQIVTLLKDKINFGRDLRRGDRFEVVLSRQLVGEKLTGNSEIQAIKIFNRGKEITAYLHQDGQYYDKNGDSLQRAFQRYPVDSKWRISSNFDPRRLHPVTKRVAPHNGTDFAMPIGTPVYTSGDGVVVMTRNHPYAGNYVVIQHGNTYMTRYLHLSKILVKKGQKVSRGQRIGLSGNTGRVTGPHLHYELIVRGRPVNAMKANIPMASSVPKKEMAQFIAKRKELDQMLARQESMLAAQ" }, { "InterPro": [ { "InterPro-ID": "IPR012328", "InterPro-Name": "Chalcone/stilbene_synt_C", "InterPro-Type": "DOMAIN", "Beg": 244, "End": 388 }, { "InterPro-ID": "IPR001099", "InterPro-Name": "Chalcone/stilbene_synt_N", "InterPro-Type": "DOMAIN", "Beg": 13, "End": 234 }, { "InterPro-ID": "IPR016039", "InterPro-Name": "Thiolase-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 8, "End": 241 }, { "InterPro-ID": "IPR011141", "InterPro-Name": "Polyketide_synthase_type-III", "InterPro-Type": "FAMILY", "Beg": 9, "End": 389 }, { "InterPro-ID": "IPR016039", "InterPro-Name": "Thiolase-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 21, "End": 234 }, { "InterPro-ID": "IPR016039", "InterPro-Name": "Thiolase-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 243, "End": 389 }, { "InterPro-ID": "IPR016039", "InterPro-Name": "Thiolase-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 221, "End": 386 }, { "InterPro-ID": "IPR011141", "InterPro-Name": "Polyketide_synthase_type-III", "InterPro-Type": "FAMILY", "Beg": 17, "End": 387 } ], "response#1": "MADLGFGDARSGNGSRSQCSRGKAMLLALGKGLPEQVLPQEKVVETYLQDTICDDPATRAKLERLCKTTTVRTRYTVMSKELLDEHPELRTEGTPTLTPRLDICNAAVLELGATAARAALGEWGRPAADITHLVYISSSELRLPGGDLFLATRLGLHPNTVRTSLLFLGCSGGAAALRTAKDIAENNPGSRVLVVAAETTVLGFRPPSPDRPYDLVGAALFGDGASAAIIGAGPIAAEESPFLELQFSTQEFLPGTDKVIDGKITEEGINFKLGRDLPEKIENRIEGFCRTLMDRVGIKEFNDVFWAVHPGGPAILNRLEVCLELQPEKLKISRKALMNYGNVSSNTVFYVLEYLRDELKKGMIREEWGLILAFGPGITFEGMLVRGIN", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Chalcone/stilbene_synt_C, Chalcone/stilbene_synt_N that are essential for its biological function; 2. The protein should belong to Polyketide_synthase_type-III, Polyketide_synthase_type-III that shares evolutionary origin and functional similarity; 3. The protein should be classified within Thiolase-like, Thiolase-like, Thiolase-like, Thiolase-like sharing conserved structural features. The designed protein sequence is ", "reference": "MADLGFGDARSGNGSRSQCSRGKAMLLALGKGLPEQVLPQEKVVETYLQDTICDDPATRAKLERLCKTTTVRTRYTVMSKELLDEHPELRTEGTPTLTPRLDICNAAVLELGATAARAALGEWGRPAADITHLVYISSSELRLPGGDLFLATRLGLHPNTVRTSLLFLGCSGGAAALRTAKDIAENNPGSRVLVVAAETTVLGFRPPSPDRPYDLVGAALFGDGASAAIIGAGPIAAEESPFLELQFSTQEFLPGTDKVIDGKITEEGINFKLGRDLPEKIENRIEGFCRTLMDRVGIKEFNDVFWAVHPGGPAILNRLEVCLELQPEKLKISRKALMNYGNVSSNTVFYVLEYLRDELKKGMIREEWGLILAFGPGITFEGMLVRGIN" }, { "InterPro": [ { "InterPro-ID": "IPR000776", "InterPro-Name": "Fusion_F0_Paramyxovir", "InterPro-Type": "FAMILY", "Beg": 22, "End": 502 } ], "response#1": "MKAFSVTCLGFAVFSSSICVNINILQQIGYIKQQVRQLSYYSQSSSSYIVVKLLPNIQPTDNSCEFKSVTQYNKTLSNLLLPIAENINNIASPSPGSRRHKRFAGIAIGIAALGVATAAQVTAAVSLVQAQTNARAIAAMKNSIQATNRAIFEVKEGTQQLAIAVQAIQDHINTIMNTQLNNMTCQILDNQLATFLGLYLTELTTVFQPQLINPALSPISIQALRSLLGSMTPAVVQATLSTSISAAEILSAGLMEGQIVSVLLDEMQMIVKVNIPTIVTQSNALVIDFYSISSFINNQESIIQLPDRILEIGNEQWSYPAKNCKLTRHHIFCQYNEAERLSLESKLCLAGNISACVFSPIAGSYMRRFVALDGTIVANCRSLTCLCKSPSYPIYQPDHHAVTTIDLTACQTLSLDGLDFSIVSLSNITYAENLTISLSQTINTQPIDISTELSKVNASLQNAVKYIKESNHQLLSVSVNSKIGAIIVTALVLSILSIIISLLFCCWAYIATKEIRRINFKTNHINTISSSVDDLIRY", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Fusion_F0_Paramyxovir that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MKAFSVTCLGFAVFSSSICVNINILQQIGYIKQQVRQLSYYSQSSSSYIVVKLLPNIQPTDNSCEFKSVTQYNKTLSNLLLPIAENINNIASPSPGSRRHKRFAGIAIGIAALGVATAAQVTAAVSLVQAQTNARAIAAMKNSIQATNRAIFEVKEGTQQLAIAVQAIQDHINTIMNTQLNNMTCQILDNQLATFLGLYLTELTTVFQPQLINPALSPISIQALRSLLGSMTPAVVQATLSTSISAAEILSAGLMEGQIVSVLLDEMQMIVKVNIPTIVTQSNALVIDFYSISSFINNQESIIQLPDRILEIGNEQWSYPAKNCKLTRHHIFCQYNEAERLSLESKLCLAGNISACVFSPIAGSYMRRFVALDGTIVANCRSLTCLCKSPSYPIYQPDHHAVTTIDLTACQTLSLDGLDFSIVSLSNITYAENLTISLSQTINTQPIDISTELSKVNASLQNAVKYIKESNHQLLSVSVNSKIGAIIVTALVLSILSIIISLLFCCWAYIATKEIRRINFKTNHINTISSSVDDLIRY" }, { "InterPro": [ { "InterPro-ID": "IPR015424", "InterPro-Name": "PyrdxlP-dep_Trfase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 146, "End": 524 }, { "InterPro-ID": "IPR015421", "InterPro-Name": "PyrdxlP-dep_Trfase_major", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 158, "End": 408 }, { "InterPro-ID": "IPR020578", "InterPro-Name": "Aminotrans_V_PyrdxlP_BS", "InterPro-Type": "BINDING_SITE", "Beg": 341, "End": 360 }, { "InterPro-ID": "IPR000192", "InterPro-Name": "Aminotrans_V_dom", "InterPro-Type": "DOMAIN", "Beg": 148, "End": 515 }, { "InterPro-ID": "IPR015422", "InterPro-Name": "PyrdxlP-dep_Trfase_small", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 148, "End": 514 } ], "response#1": "MKFLQIIKHLKLQNKKNALDNFVNCRTYEHISNINKLFLNNFSSTKEHSEHGQVKHENFLNSTLKYEENSQNGSTNNLKNGKYNMYVSEGNVNINEEKYKDNNISSNNTQYNNNSSNSGSLNDEGPLWKEHIDDVVNENKKKKMNRFYLDSQATTMIDPRVLDKMLPYMTYIYGNAHSRNHFFGWESEKAVEDARTNLLNLINGKNNKEIIFTSGATESNNLALIGICTYYNKLNKQKNHIITSQIEHKCILQTCRFLQTKGFEVTYLKPDTNGLVKLDDIKNSIKDNTIMASFIFVNNEIGVIQDIENIGNLCKEKNILFHTDASQAAGKVPIDVQKMNIDLMSMSGHKLYGPKGIGALYIKRKKPNIRLNALIHGGGQERGLRSGTLPTHLIVGFGEAAKVCSLEMNRDEKKVRYFFNYVKDYLTKHLDYIVFNGCQINRYYGNMNISFLFVEGESLLMSLNEIALSSGSACTSSTLEPSYVLRSIGISEDIAHTSIRIGFNRFTTFFEVQQLCINLVKSVERLRSISPLYEMELEKKNPSNDDIPKFIWT", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Aminotrans_V_dom that are essential for its biological function; 2. The protein should be classified within PyrdxlP-dep_Trfase, PyrdxlP-dep_Trfase_major, PyrdxlP-dep_Trfase_small sharing conserved structural features; 3. The protein should include a Aminotrans_V_PyrdxlP_BS that enables ligand binding under diverse conditions. The designed protein sequence is ", "reference": "MKFLQIIKHLKLQNKKNALDNFVNCRTYEHISNINKLFLNNFSSTKEHSEHGQVKHENFLNSTLKYEENSQNGSTNNLKNGKYNMYVSEGNVNINEEKYKDNNISSNNTQYNNNSSNSGSLNDEGPLWKEHIDDVVNENKKKKMNRFYLDSQATTMIDPRVLDKMLPYMTYIYGNAHSRNHFFGWESEKAVEDARTNLLNLINGKNNKEIIFTSGATESNNLALIGICTYYNKLNKQKNHIITSQIEHKCILQTCRFLQTKGFEVTYLKPDTNGLVKLDDIKNSIKDNTIMASFIFVNNEIGVIQDIENIGNLCKEKNILFHTDASQAAGKVPIDVQKMNIDLMSMSGHKLYGPKGIGALYIKRKKPNIRLNALIHGGGQERGLRSGTLPTHLIVGFGEAAKVCSLEMNRDEKKVRYFFNYVKDYLTKHLDYIVFNGCQINRYYGNMNISFLFVEGESLLMSLNEIALSSGSACTSSTLEPSYVLRSIGISEDIAHTSIRIGFNRFTTFFEVQQLCINLVKSVERLRSISPLYEMELEKKNPSNDDIPKFIWT" }, { "InterPro": [ { "InterPro-ID": "IPR006077", "InterPro-Name": "Vinculin/catenin", "InterPro-Type": "FAMILY", "Beg": 34, "End": 527 }, { "InterPro-ID": "IPR006077", "InterPro-Name": "Vinculin/catenin", "InterPro-Type": "FAMILY", "Beg": 528, "End": 733 }, { "InterPro-ID": "IPR036723", "InterPro-Name": "Alpha-catenin/vinculin-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 568, "End": 734 }, { "InterPro-ID": "IPR030045", "InterPro-Name": "CTNNAL1", "InterPro-Type": "FAMILY", "Beg": 17, "End": 745 }, { "InterPro-ID": "IPR036723", "InterPro-Name": "Alpha-catenin/vinculin-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 403, "End": 532 }, { "InterPro-ID": "IPR036723", "InterPro-Name": "Alpha-catenin/vinculin-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 77, "End": 278 }, { "InterPro-ID": "IPR001033", "InterPro-Name": "Alpha_catenin", "InterPro-Type": "FAMILY", "Beg": 147, "End": 165 }, { "InterPro-ID": "IPR001033", "InterPro-Name": "Alpha_catenin", "InterPro-Type": "FAMILY", "Beg": 128, "End": 146 }, { "InterPro-ID": "IPR001033", "InterPro-Name": "Alpha_catenin", "InterPro-Type": "FAMILY", "Beg": 27, "End": 51 }, { "InterPro-ID": "IPR001033", "InterPro-Name": "Alpha_catenin", "InterPro-Type": "FAMILY", "Beg": 399, "End": 419 } ], "response#1": "MAASSMSSLTSSYHTTAMPSSNSVVPPFDARNLEIKTKSIEQTLIPLVTQITTLVNYKESYMASGKPKSERAMRAALKIGSAVEAAIERFVCVGETIADENADIQPEMYDACTEARLAGASMANLSCACNDDPNSVVDKAVLVRASRQLLSSVTRVLLLADRVLVKQVLRAEDKIAFSLSRLESTRSFNDFVKVFAVFGGEMVELAHRSGDRQHDLKSEKRKAQMSIARTSLERLTMLLLTASKTYLRHPDCDSALQCRDGVFYQMKLSLELIAICVCDGILTTEKSRYIQDEPDMPIDIALQLTANAAIKQLTEMLEMIRMTVRVGAGVRERIVSALDALCQLTQDFTDSAYTPHHQREQILDFLEECRFEMTNLIQPDENEQLAASGLEVTVERLNRRLKDLSKQLQIVAMEQISEVLRANEDQVLLSSMKACAVSGDIDGVEKYMHKFREHADHMQEVCRLLHHISITDALHVHTGHVERNMRALAPLTILAGRTLCVHPSSRIARENLEVFCDTWGQAVNDLSRVAKESDVAANGRVAAEKQAYMSLPRPGKHGTTQKPSKPITLDVEDQQKMAKVGLEMKLLTSEVDAEAEKWDEYAENDIVKRAKAMSSMAYNMYLFTRGDGPLKTTHDLFTQAEFFAEQANQMYRTVREFSYEVPGSAEKSDLSAILERIPLHCQQLQVMVKSPTVGKTATFGKVDSVIQETKNLMNEIAKLVTASFVCATKYEIEFRGGSVNGRTGADGERTSRESTVWRRTPSIRRAAPPTSSHLSANNSSSIHI", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Vinculin/catenin, Vinculin/catenin, CTNNAL1, Alpha_catenin, Alpha_catenin, Alpha_catenin, Alpha_catenin that shares evolutionary origin and functional similarity; 2. The protein should be classified within Alpha-catenin/vinculin-like_sf, Alpha-catenin/vinculin-like_sf, Alpha-catenin/vinculin-like_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MAASSMSSLTSSYHTTAMPSSNSVVPPFDARNLEIKTKSIEQTLIPLVTQITTLVNYKESYMASGKPKSERAMRAALKIGSAVEAAIERFVCVGETIADENADIQPEMYDACTEARLAGASMANLSCACNDDPNSVVDKAVLVRASRQLLSSVTRVLLLADRVLVKQVLRAEDKIAFSLSRLESTRSFNDFVKVFAVFGGEMVELAHRSGDRQHDLKSEKRKAQMSIARTSLERLTMLLLTASKTYLRHPDCDSALQCRDGVFYQMKLSLELIAICVCDGILTTEKSRYIQDEPDMPIDIALQLTANAAIKQLTEMLEMIRMTVRVGAGVRERIVSALDALCQLTQDFTDSAYTPHHQREQILDFLEECRFEMTNLIQPDENEQLAASGLEVTVERLNRRLKDLSKQLQIVAMEQISEVLRANEDQVLLSSMKACAVSGDIDGVEKYMHKFREHADHMQEVCRLLHHISITDALHVHTGHVERNMRALAPLTILAGRTLCVHPSSRIARENLEVFCDTWGQAVNDLSRVAKESDVAANGRVAAEKQAYMSLPRPGKHGTTQKPSKPITLDVEDQQKMAKVGLEMKLLTSEVDAEAEKWDEYAENDIVKRAKAMSSMAYNMYLFTRGDGPLKTTHDLFTQAEFFAEQANQMYRTVREFSYEVPGSAEKSDLSAILERIPLHCQQLQVMVKSPTVGKTATFGKVDSVIQETKNLMNEIAKLVTASFVCATKYEIEFRGGSVNGRTGADGERTSRESTVWRRTPSIRRAAPPTSSHLSANNSSSIHI" }, { "InterPro": [ { "InterPro-ID": "IPR054746", "InterPro-Name": "GLMA-like_second", "InterPro-Type": "DOMAIN", "Beg": 468, "End": 601 }, { "InterPro-ID": "IPR001944", "InterPro-Name": "Glycoside_Hdrlase_35", "InterPro-Type": "FAMILY", "Beg": 7, "End": 639 }, { "InterPro-ID": "IPR029062", "InterPro-Name": "Class_I_gatase-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 475, "End": 657 }, { "InterPro-ID": "IPR031330", "InterPro-Name": "Gly_Hdrlase_35_cat", "InterPro-Type": "DOMAIN", "Beg": 10, "End": 205 }, { "InterPro-ID": "IPR001944", "InterPro-Name": "Glycoside_Hdrlase_35", "InterPro-Type": "FAMILY", "Beg": 13, "End": 30 }, { "InterPro-ID": "IPR001944", "InterPro-Name": "Glycoside_Hdrlase_35", "InterPro-Type": "FAMILY", "Beg": 93, "End": 112 }, { "InterPro-ID": "IPR017853", "InterPro-Name": "Glycoside_hydrolase_SF", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 7, "End": 388 } ], "response#1": "MKPHNSEKYFVKNGQPHFLISGEVHYFRINPKLWRNHLQLLKQTGADTVSTYIPWDWHEIEEDDFDFEGKTHPARNLIRFIKLCKEENLDLIVKPGPYILAEYENQGLPSWLLKKLSKNAFALDENGNVISPDLVSYLSDEFLEYTFKWYDKVMPIISKHQKEHYGPITMMQLCNEIGVFQWLSGKSDYNPKVINLYKEFIIQRYKTIEKLNSVYSTNYNSFDDLKAPSGKIKLRSDYCAYFDFHLFFREYYNKYISILKNKIRSFGINIKLTHNIPGWIYGNASELPMLISTYSEIMKNHPDIIFGLDHIPEFVSFRNAHSDLACNKILEAMQPEAPVWAAEFQAGTREHHVKAYAKDLETFYIASLAHGIKGFNYYMFSQGINPEGKGFYGKTFYFQTALDAASNKLALYDSIKKVNRFIRKEQKDLLRTNVNSEICVGFYKPYFFTELISSQLLKEKKLNVEELGLYIDPRFLREEILFNGLLRGLQTLNYNYDVVDLENCDLKSLTAYKQLWITSAEFMDAETQNLLSEFVLNGGNLILYPAVPTLDNYLNRCEILKNNFGIEFITKDSSHKVSAFGIEDVFTAFSKKQIYNDTNSKPIAFTQENEICGIRKKIGKGELTILGFAFGYTSDEHLELIDKLVKLNKIKRELFVSDKDIQFVVRENNKSRYIFFLNYHNERKTFNYRKSSELKKKKSEEISIAPFSYKVIKENK", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more GLMA-like_second, Gly_Hdrlase_35_cat that are essential for its biological function; 2. The protein should belong to Glycoside_Hdrlase_35, Glycoside_Hdrlase_35, Glycoside_Hdrlase_35 that shares evolutionary origin and functional similarity; 3. The protein should be classified within Class_I_gatase-like, Glycoside_hydrolase_SF sharing conserved structural features. The designed protein sequence is ", "reference": "MKPHNSEKYFVKNGQPHFLISGEVHYFRINPKLWRNHLQLLKQTGADTVSTYIPWDWHEIEEDDFDFEGKTHPARNLIRFIKLCKEENLDLIVKPGPYILAEYENQGLPSWLLKKLSKNAFALDENGNVISPDLVSYLSDEFLEYTFKWYDKVMPIISKHQKEHYGPITMMQLCNEIGVFQWLSGKSDYNPKVINLYKEFIIQRYKTIEKLNSVYSTNYNSFDDLKAPSGKIKLRSDYCAYFDFHLFFREYYNKYISILKNKIRSFGINIKLTHNIPGWIYGNASELPMLISTYSEIMKNHPDIIFGLDHIPEFVSFRNAHSDLACNKILEAMQPEAPVWAAEFQAGTREHHVKAYAKDLETFYIASLAHGIKGFNYYMFSQGINPEGKGFYGKTFYFQTALDAASNKLALYDSIKKVNRFIRKEQKDLLRTNVNSEICVGFYKPYFFTELISSQLLKEKKLNVEELGLYIDPRFLREEILFNGLLRGLQTLNYNYDVVDLENCDLKSLTAYKQLWITSAEFMDAETQNLLSEFVLNGGNLILYPAVPTLDNYLNRCEILKNNFGIEFITKDSSHKVSAFGIEDVFTAFSKKQIYNDTNSKPIAFTQENEICGIRKKIGKGELTILGFAFGYTSDEHLELIDKLVKLNKIKRELFVSDKDIQFVVRENNKSRYIFFLNYHNERKTFNYRKSSELKKKKSEEISIAPFSYKVIKENK" }, { "InterPro": [ { "InterPro-ID": "IPR002048", "InterPro-Name": "EF_hand_dom", "InterPro-Type": "DOMAIN", "Beg": 210, "End": 245 }, { "InterPro-ID": "IPR002048", "InterPro-Name": "EF_hand_dom", "InterPro-Type": "DOMAIN", "Beg": 59, "End": 94 }, { "InterPro-ID": "IPR002048", "InterPro-Name": "EF_hand_dom", "InterPro-Type": "DOMAIN", "Beg": 214, "End": 242 }, { "InterPro-ID": "IPR002048", "InterPro-Name": "EF_hand_dom", "InterPro-Type": "DOMAIN", "Beg": 176, "End": 204 }, { "InterPro-ID": "IPR002048", "InterPro-Name": "EF_hand_dom", "InterPro-Type": "DOMAIN", "Beg": 139, "End": 167 }, { "InterPro-ID": "IPR002048", "InterPro-Name": "EF_hand_dom", "InterPro-Type": "DOMAIN", "Beg": 63, "End": 91 }, { "InterPro-ID": "IPR002048", "InterPro-Name": "EF_hand_dom", "InterPro-Type": "DOMAIN", "Beg": 99, "End": 127 }, { "InterPro-ID": "IPR018247", "InterPro-Name": "EF_Hand_1_Ca_BS", "InterPro-Type": "BINDING_SITE", "Beg": 185, "End": 197 }, { "InterPro-ID": "IPR011992", "InterPro-Name": "EF-hand-dom_pair", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 172, "End": 258 }, { "InterPro-ID": "IPR018247", "InterPro-Name": "EF_Hand_1_Ca_BS", "InterPro-Type": "BINDING_SITE", "Beg": 108, "End": 120 }, { "InterPro-ID": "IPR018247", "InterPro-Name": "EF_Hand_1_Ca_BS", "InterPro-Type": "BINDING_SITE", "Beg": 223, "End": 235 }, { "InterPro-ID": "IPR018247", "InterPro-Name": "EF_Hand_1_Ca_BS", "InterPro-Type": "BINDING_SITE", "Beg": 72, "End": 84 }, { "InterPro-ID": "IPR002048", "InterPro-Name": "EF_hand_dom", "InterPro-Type": "DOMAIN", "Beg": 95, "End": 130 }, { "InterPro-ID": "IPR011992", "InterPro-Name": "EF-hand-dom_pair", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 60, "End": 199 }, { "InterPro-ID": "IPR002048", "InterPro-Name": "EF_hand_dom", "InterPro-Type": "DOMAIN", "Beg": 135, "End": 170 }, { "InterPro-ID": "IPR002048", "InterPro-Name": "EF_hand_dom", "InterPro-Type": "DOMAIN", "Beg": 140, "End": 199 }, { "InterPro-ID": "IPR002048", "InterPro-Name": "EF_hand_dom", "InterPro-Type": "DOMAIN", "Beg": 61, "End": 123 }, { "InterPro-ID": "IPR018247", "InterPro-Name": "EF_Hand_1_Ca_BS", "InterPro-Type": "BINDING_SITE", "Beg": 148, "End": 160 }, { "InterPro-ID": "IPR002048", "InterPro-Name": "EF_hand_dom", "InterPro-Type": "DOMAIN", "Beg": 172, "End": 207 }, { "InterPro-ID": "IPR002048", "InterPro-Name": "EF_hand_dom", "InterPro-Type": "DOMAIN", "Beg": 216, "End": 238 } ], "response#1": "MMKINLYKLLCFICVIFLLHKNVVRSGDNMKYNDMKGLDDLSKLNDDQVKDILGLKIDGAKERIEKLFHLIDKNNDKEITEEELNTWSSFLKNEIFLKQVQAEMGQIDSDKDGFISLNELNDAFAQNLDAKEVEKHSEGLLKRFQIVDKDKDGKLSINEVGLLIDPMKDEELKELEINEILEHHDVNKDGKISLDEFKQTRSDESSGVKKDDEMALDDFNFFDANKDGFIDKEEIIKVYFDPAHESGAINVNEIKENIFEGKKITYDLWNEKALKIAVTSLTDYGDVIRYPEDFKLDIGKNVILPTARSRAFEDDDMDADNTEDDKDEADDASQQKSPAIDEL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more EF_hand_dom, EF_hand_dom, EF_hand_dom, EF_hand_dom, EF_hand_dom, EF_hand_dom, EF_hand_dom, EF_hand_dom, EF_hand_dom, EF_hand_dom, EF_hand_dom, EF_hand_dom, EF_hand_dom that are essential for its biological function; 2. The protein should be classified within EF-hand-dom_pair, EF-hand-dom_pair sharing conserved structural features; 3. The protein should include a EF_Hand_1_Ca_BS, EF_Hand_1_Ca_BS, EF_Hand_1_Ca_BS, EF_Hand_1_Ca_BS, EF_Hand_1_Ca_BS that enables ligand binding under diverse conditions. The designed protein sequence is ", "reference": "MMKINLYKLLCFICVIFLLHKNVVRSGDNMKYNDMKGLDDLSKLNDDQVKDILGLKIDGAKERIEKLFHLIDKNNDKEITEEELNTWSSFLKNEIFLKQVQAEMGQIDSDKDGFISLNELNDAFAQNLDAKEVEKHSEGLLKRFQIVDKDKDGKLSINEVGLLIDPMKDEELKELEINEILEHHDVNKDGKISLDEFKQTRSDESSGVKKDDEMALDDFNFFDANKDGFIDKEEIIKVYFDPAHESGAINVNEIKENIFEGKKITYDLWNEKALKIAVTSLTDYGDVIRYPEDFKLDIGKNVILPTARSRAFEDDDMDADNTEDDKDEADDASQQKSPAIDEL" }, { "InterPro": [ { "InterPro-ID": "IPR020558", "InterPro-Name": "DiOHA_6PGluconate_deHydtase_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 159, "End": 169 }, { "InterPro-ID": "IPR050165", "InterPro-Name": "DHAD_IlvD/Edd", "InterPro-Type": "FAMILY", "Beg": 33, "End": 595 }, { "InterPro-ID": "IPR004404", "InterPro-Name": "DihydroxyA_deHydtase", "InterPro-Type": "FAMILY", "Beg": 55, "End": 595 }, { "InterPro-ID": "IPR004404", "InterPro-Name": "DihydroxyA_deHydtase", "InterPro-Type": "FAMILY", "Beg": 41, "End": 595 }, { "InterPro-ID": "IPR000581", "InterPro-Name": "ILV_EDD_N", "InterPro-Type": "DOMAIN", "Beg": 71, "End": 389 }, { "InterPro-ID": "IPR020558", "InterPro-Name": "DiOHA_6PGluconate_deHydtase_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 503, "End": 514 }, { "InterPro-ID": "IPR056740", "InterPro-Name": "ILV_EDD_C", "InterPro-Type": "DOMAIN", "Beg": 401, "End": 592 }, { "InterPro-ID": "IPR042096", "InterPro-Name": "Dihydro-acid_dehy_C", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 415, "End": 566 }, { "InterPro-ID": "IPR037237", "InterPro-Name": "IlvD/EDD_N", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 27, "End": 414 } ], "response#1": "MFASRIRSRALGLHPRARFENTRLPASTTGRRYKSDETLNRVSSKITQPKSQGASQAMLYATGLTEEDMSKPQVGISSVWFEGNPCNMHLHDLSAIVRDSVHRAGLVPMRFNSVGVSDGISMGTKGMRYSLQSRELIADGIETVMNAQWYDANVSLPGCDKNMPGVLMAMGRTNRPSIMVYGGSIKPGCSAKGQKLDLVSAFQSYGQFITGQIDEKERFDIIRNACPGRGACGGMYTANTLATAIETMGMTVPGSSSCPADDPKKLVECENIGEVVKTMLREDIKPRDVLTRQAFENAMIVVNILGGSTNAVLHLIAIADSVGIKLTIDDFQAVSDKTPFLADLKPSGKYLMNDLYNIGGTPALLKYLLKEGLIDGSGITVTGKTMKENVASWPDFPADQDIIRPLSNPIKPSGHLQILRGSLAPGGSVGKITGKEGLRFEGTAKCYDYEDAFIESLERGEIKKGEKTVVIIRYEGPKGGPGMPEMLKPSAAIMGAGLGQDVALLTDGRFSGGSHGFLIGHIVPEAMEGGPIALARDGDRIVIDAEERVVDLDIPTEELEKRRKEWKAPPLRYQKGTLKKYCTLVSDASHGCVTDGPI", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more ILV_EDD_N, ILV_EDD_C that are essential for its biological function; 2. The protein should belong to DHAD_IlvD/Edd, DihydroxyA_deHydtase, DihydroxyA_deHydtase that shares evolutionary origin and functional similarity; 3. The protein should be classified within Dihydro-acid_dehy_C, IlvD/EDD_N sharing conserved structural features; 4. The protein should contain DiOHA_6PGluconate_deHydtase_CS, DiOHA_6PGluconate_deHydtase_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MFASRIRSRALGLHPRARFENTRLPASTTGRRYKSDETLNRVSSKITQPKSQGASQAMLYATGLTEEDMSKPQVGISSVWFEGNPCNMHLHDLSAIVRDSVHRAGLVPMRFNSVGVSDGISMGTKGMRYSLQSRELIADGIETVMNAQWYDANVSLPGCDKNMPGVLMAMGRTNRPSIMVYGGSIKPGCSAKGQKLDLVSAFQSYGQFITGQIDEKERFDIIRNACPGRGACGGMYTANTLATAIETMGMTVPGSSSCPADDPKKLVECENIGEVVKTMLREDIKPRDVLTRQAFENAMIVVNILGGSTNAVLHLIAIADSVGIKLTIDDFQAVSDKTPFLADLKPSGKYLMNDLYNIGGTPALLKYLLKEGLIDGSGITVTGKTMKENVASWPDFPADQDIIRPLSNPIKPSGHLQILRGSLAPGGSVGKITGKEGLRFEGTAKCYDYEDAFIESLERGEIKKGEKTVVIIRYEGPKGGPGMPEMLKPSAAIMGAGLGQDVALLTDGRFSGGSHGFLIGHIVPEAMEGGPIALARDGDRIVIDAEERVVDLDIPTEELEKRRKEWKAPPLRYQKGTLKKYCTLVSDASHGCVTDGPI" }, { "InterPro": [ { "InterPro-ID": "IPR023213", "InterPro-Name": "CAT-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 2519, "End": 2885 }, { "InterPro-ID": "IPR020806", "InterPro-Name": "PKS_PP-bd", "InterPro-Type": "DOMAIN", "Beg": 2371, "End": 2442 }, { "InterPro-ID": "IPR001242", "InterPro-Name": "Condensatn", "InterPro-Type": "DOMAIN", "Beg": 2519, "End": 2953 }, { "InterPro-ID": "IPR009081", "InterPro-Name": "PP-bd_ACP", "InterPro-Type": "DOMAIN", "Beg": 2376, "End": 2434 }, { "InterPro-ID": "IPR016036", "InterPro-Name": "Malonyl_transacylase_ACP-bd", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 684, "End": 749 }, { "InterPro-ID": "IPR020845", "InterPro-Name": "AMP-binding_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 3118, "End": 3129 }, { "InterPro-ID": "IPR016035", "InterPro-Name": "Acyl_Trfase/lysoPLipase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 550, "End": 855 }, { "InterPro-ID": "IPR036291", "InterPro-Name": "NAD(P)-bd_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1674, "End": 1768 }, { "InterPro-ID": "IPR042104", "InterPro-Name": "PKS_dehydratase_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 926, "End": 1251 }, { "InterPro-ID": "IPR006162", "InterPro-Name": "Ppantetheine_attach_site", "InterPro-Type": "PTM", "Beg": 2397, "End": 2412 }, { "InterPro-ID": "IPR018201", "InterPro-Name": "Ketoacyl_synth_AS", "InterPro-Type": "ACTIVE_SITE", "Beg": 171, "End": 187 }, { "InterPro-ID": "IPR049551", "InterPro-Name": "PKS_DH_C", "InterPro-Type": "DOMAIN", "Beg": 1100, "End": 1250 }, { "InterPro-ID": "IPR020841", "InterPro-Name": "PKS_Beta-ketoAc_synthase_dom", "InterPro-Type": "DOMAIN", "Beg": 10, "End": 442 }, { "InterPro-ID": "IPR014043", "InterPro-Name": "Acyl_transferase_dom", "InterPro-Type": "DOMAIN", "Beg": 551, "End": 870 }, { "InterPro-ID": "IPR045851", "InterPro-Name": "AMP-bd_C_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 3381, "End": 3484 }, { "InterPro-ID": "IPR049900", "InterPro-Name": "PKS_mFAS_DH", "InterPro-Type": "DOMAIN", "Beg": 943, "End": 1253 }, { "InterPro-ID": "IPR029063", "InterPro-Name": "SAM-dependent_MTases_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1390, "End": 1557 }, { "InterPro-ID": "IPR042099", "InterPro-Name": "ANL_N_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 2970, "End": 3378 }, { "InterPro-ID": "IPR010071", "InterPro-Name": "AA_adenyl_dom", "InterPro-Type": "DOMAIN", "Beg": 2998, "End": 3404 }, { "InterPro-ID": "IPR014030", "InterPro-Name": "Ketoacyl_synth_N", "InterPro-Type": "DOMAIN", "Beg": 8, "End": 258 }, { "InterPro-ID": "IPR020841", "InterPro-Name": "PKS_Beta-ketoAc_synthase_dom", "InterPro-Type": "DOMAIN", "Beg": 7, "End": 439 }, { "InterPro-ID": "IPR000873", "InterPro-Name": "AMP-dep_synth/lig_dom", "InterPro-Type": "DOMAIN", "Beg": 2978, "End": 3329 }, { "InterPro-ID": "IPR016039", "InterPro-Name": "Thiolase-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 4, "End": 437 }, { "InterPro-ID": "IPR014031", "InterPro-Name": "Ketoacyl_synth_C", "InterPro-Type": "DOMAIN", "Beg": 268, "End": 385 }, { "InterPro-ID": "IPR013968", "InterPro-Name": "PKS_KR", "InterPro-Type": "DOMAIN", "Beg": 2083, "End": 2257 }, { "InterPro-ID": "IPR009081", "InterPro-Name": "PP-bd_ACP", "InterPro-Type": "DOMAIN", "Beg": 2364, "End": 2442 }, { "InterPro-ID": "IPR029063", "InterPro-Name": "SAM-dependent_MTases_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1287, "End": 1562 }, { "InterPro-ID": "IPR036291", "InterPro-Name": "NAD(P)-bd_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 2080, "End": 2312 }, { "InterPro-ID": "IPR001227", "InterPro-Name": "Ac_transferase_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 548, "End": 859 }, { "InterPro-ID": "IPR013217", "InterPro-Name": "Methyltransf_12", "InterPro-Type": "DOMAIN", "Beg": 1407, "End": 1508 }, { "InterPro-ID": "IPR014043", "InterPro-Name": "Acyl_transferase_dom", "InterPro-Type": "DOMAIN", "Beg": 551, "End": 879 }, { "InterPro-ID": "IPR050091", "InterPro-Name": "PKS_NRPS_Biosynth_Enz", "InterPro-Type": "FAMILY", "Beg": 9, "End": 2635 }, { "InterPro-ID": "IPR049552", "InterPro-Name": "PKS_DH_N", "InterPro-Type": "DOMAIN", "Beg": 943, "End": 1033 }, { "InterPro-ID": "IPR020807", "InterPro-Name": "PKS_DH", "InterPro-Type": "DOMAIN", "Beg": 943, "End": 1126 }, { "InterPro-ID": "IPR016039", "InterPro-Name": "Thiolase-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 6, "End": 520 }, { "InterPro-ID": "IPR036736", "InterPro-Name": "ACP-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 2367, "End": 2459 } ], "response#1": "MAPHPQPEPIAIVGSSCRFPGGSSSPSRLWQLLSNPQDVSKEIPEDRFELQGFYHPKGAHHGTTNVQRAYTLDEDVRIFDAGFFNISPNEADSMDPQQRLLMEVVYEALESGGHPLEGLRGSDTAVFVGTMSVDYNDILIRDLESTPTYFSTGTSRAILANRISYCFDWHGPSMTIDTACSSSMVALHQSVKALRAGEARVAVAGGTELLLGPEQFVGESKMNLLSPTGRSRMWDADADGYARGDGVAAVILKRLSDAIADGDHIESIIRDTGVNQDGKSTGLTVPSSEAQAALIRSTYARAGLDLSNPDDWPQFFEAHGTGTKVGDPREAAAISGCFGSQPIHGNPLYVGSIKTIIGHTEGTAGLAGVLKASLAIQHGVIPPNMLLNRLNPDVKQYYTNLQIPTSPIQWPVLPAGVPRRASVNSFGFGGTNGHAIIEGYEPKASNFDGEQQQPVAPVTSFVFSATTEESLVALLQSYSNYLKINPTIDLHSLAWTLQSRRSAFAYKTAVAASTIDGLVSRLESKVKQAKSTPPTPAGVRSTPATPHLLGVFTGQGAQWPTMGAHLIQISATVRAKLEQLDHSLATLPEADRPSWRIADQLLAPKGESRLSEAALSQPLCTAVQVVLVDLLRSAGITFDAVVGHSSGEIGAAYAAGFISAADAIRIAYYRGVHAKLAQGQKGQKGAMLAVGTSWEDAQELIDLPAFAGKIRIAAHNSAASLTLSGDADAIAHAKRVFDEEKKFARLLLVDTAYHSHHMLPCSGPYIESLRACQIQVNKDRDSSCTWFSSVRADGKPMVADEELQDVYWSDNMVNTVLFADAVKRAAANESLNLAIEVGPHPALKGPAQQNISDVRPSSPLPYTGLLNRGNSDVEAFSDALGSVWTYLGPGTVDFQSYTRLVTPAAPAPKLLTGLPSYQFSRDRVHWHESRRAKKMRRRGAAFHELLGVPSPDNTDQDLRWTNFLKSSEIPWLDGHKLQGQTVFPAAGYVAMALEAGKWLAGDRSVQVLEVRNLTIDRAITFDDGAGFAVETLVALTGISPMSAAKNNSSSSSQMADFAVYACPNTGSLGLELVSSGQVHIVYGAPSFSVLASTPLDDSNMTSIDCEQFYSTLSGLGYGYNGPFHTLAETKRRLGQASATVATYAYSDDERPLIVHPTMLDVAFQASFLAQTSPGDEQLWSLHVPTSIKCVRINPELSASLPTASVELPLSAVLHEPESISLHSSVDVFTENKRETLLQVEGLIMKPFSPATAADDRPMFSTMEYGVAVPNAGVATGHEHPTDKEVVLAGVCDRVAYYYLRAWEAKAGDEEERFRHLLSTFVGGQHSSMTEAWSSDEEKDIQALISQYPESTDLQLLATLGDSFSTETLAQPLLDECFSRGVGFARASAGLARTVQQISHRYPHAKIVEIGAGRGHTTETVLSAIGDAFSSYTFTDTSDDIFGTVAETFQAHGKKIDYKAFNPAKAPSAQGFTEHSYDVAILPNSIYTSSSLQTALGNIRRLLKPGGYLVASAITHEPVRVQALLAGVSLSSDDPRASVSTWHSALRNAGFSGIDTISAEADRRVWPVSVLTAQAINDRTQLLRKPLSSFKGGFRLHEVVILAGKSWESSRLAEEISDLAGRFCDKVTVLEELPTDDDEISPMATFISLLDLSEPVFEEMSEEKMEGLKCLFELSKNILWVTHNARAGSPYHYASIGFGRSIAYEMPHLMLQFLDLDEVEDVVASSRVITESVVRLAALVEWEDKEMLWSLEPELYVEKGQVLVPRIRPNDEQNARINSLRRPVSEVVDPRQGTVRVVPQAGDGASLVLRKEPWDSSPLAMQIRQSTLHALAVTGESMLFVGIGTKEATGETVIALSSTNASRSVPLVSLPTNIADLDQSAGLLASTANHLLAASILASIPANGHLLLHEPAPDGSLASALASQAAEKNVRVTFSTNSATTGDATWIKLNPWTPEHLLKQQLPAGLTHFMDLASPESQVRKYLPLGCRPISVHDLARAQATNHSPGDDRTALLESLKGAVSRAITATATTASGSTAQTAVFPSQIRDLELPSSPVSIIDWTVEATVPAEVRPLDATRYFSRDRTYLLVGLAGQLGQSICEWMARHGAGTVCLTSRSAKADPEWQAAMQKLGTTVRFDVLDVTKREQVEKLVSELGTTCSPIAGVINGAAVFNDMLFSEMSLEVMERVTQPKIIGTKNLNEVFGTTPLDFFVVLSSLTSVIGNSGQTNYTAANAYMTGLVGERRSRGLTGSSLEIGRVAGIGYMERAGDIAREQLIRFGFMAISETDLHQLLAEAIHAGAPSSALAPVVTTGCRTARDDEEVPVAWFHDPRFSHKVIEAREQGSASEGKKSALPVQEQLAQATSKDEAFKVLKDCFAAKLAMISRLSDDQVGHNIPLVELGIDSLVAVEVRGWFLKELKTDMPVLKVLGGGSVADLWGSVAASPATVSKPAAAPPAPKSEDSSASSAGPSSGSRSPLETPSTPPVGEEAKQVNLSEAAERAAKFQEGKQPDSPAYVKSELVSFAQSRFWFLRLLIEDQTTFNVCFYYRITGNLRVGDLERAVRLVTNRHESLRTCFVADEKEADLAHQKVLRQSVVRLERKKIDRLEELHAEYAAMKTIPFDIASGKTLRLILLTLSPTENYLLFNYHHILMDGVSLQNFLTDLEKAYQRQPLGPPPRQLPDFSRSQRAAFQQGKMNEEVTYWRQQFPDGHHPVLPLLPVAKVNTRAPMKAFNVNQVQYRLSKTLVNQVKERAKAHRSTTFHFYLAVFRAMLFRFTEAKDLTIGIADANRNDSDVMGTIGLLLNLLTLRFQNESTQSFGDCLAESRDKAYEALHHSRVPFDVLLKELNVPRSASYSPFFQAFFDYRQGHQEKQQFGNTELEMVELHPGRTAYDMTLDITDSSDSALILFRTQAGLYNPTATQLLLDTYVHLLETFAENTSLDLGNVSLFSDEQRKRAVDVGRGLDLKSAWPETLPLRIDQIAATNRDRIALKDGHGRILTYAVMINRIEAIAEELQKSGVQEGHRVLVFEDATADWPCSMLAIMRLGAVYVPLDLRNPLPRLADVAANCEPAAILVDNTTAKDIDQVNVTQAKVVNVSHASVKPNKRVPNVSRGDAVAAILYTSGSTGKPKGIVVKHSGLRNEIEGYTTQWGLRAERALQQSAFTFNHSSDQIYTGLTNGGTVYIVPWSKRGDPIEVSQIIQEEGITYTKATPAEYALWLDYGNANLRKATNWRFGFGGGESLTPALLHQLAALGLPHLRFFNSYGPTEISISSTKMEIAYREKQPEGRIPCGYSLPNYAAYILDEQQKPLPVGMPGELWIGGAGVSLGYLNNPELTDYHFYPDPYATTEYLAQGWTRMYRTGDIAHLQADGAMVFHSRVAGDAQVKIRGLRIELGDIESNIVKTSDGALREAVVTLRDGDPPLLVAHVVFAPNHNITDTEAFLDHLLQHLPVPQYMVPVMAIPLDRMPLSNHSKVDRKALKALPLPRRTVSSDAVDVLSETMLQLRRRMGRGPPHGGTRPADCPIDQLLHHRGKLPSRRPPTIPHPTPVQRDGAAGRPPRSQQSQRHGQTDRRKHYSQRNRLEARIRTSTRFDGTLSLHYLRPTSP", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more PKS_PP-bd, Condensatn, PP-bd_ACP, PKS_DH_C, PKS_Beta-ketoAc_synthase_dom, Acyl_transferase_dom, PKS_mFAS_DH, AA_adenyl_dom, Ketoacyl_synth_N, PKS_Beta-ketoAc_synthase_dom, AMP-dep_synth/lig_dom, Ketoacyl_synth_C, PKS_KR, PP-bd_ACP, Methyltransf_12, Acyl_transferase_dom, PKS_DH_N, PKS_DH that are essential for its biological function; 2. The protein should belong to PKS_NRPS_Biosynth_Enz that shares evolutionary origin and functional similarity; 3. The protein should be classified within CAT-like_dom_sf, Malonyl_transacylase_ACP-bd, Acyl_Trfase/lysoPLipase, NAD(P)-bd_dom_sf, PKS_dehydratase_sf, AMP-bd_C_sf, SAM-dependent_MTases_sf, ANL_N_sf, Thiolase-like, SAM-dependent_MTases_sf, NAD(P)-bd_dom_sf, Ac_transferase_dom_sf, Thiolase-like, ACP-like_sf sharing conserved structural features; 4. The protein should contain AMP-binding_CS that is preserved across related proteins; 5. The protein must have Ketoacyl_synth_AS that is conserved among related catalytic enzymes; 6. The protein should contain Ppantetheine_attach_site that allow regulation through chemical modifications. The designed protein sequence is ", "reference": "MAPHPQPEPIAIVGSSCRFPGGSSSPSRLWQLLSNPQDVSKEIPEDRFELQGFYHPKGAHHGTTNVQRAYTLDEDVRIFDAGFFNISPNEADSMDPQQRLLMEVVYEALESGGHPLEGLRGSDTAVFVGTMSVDYNDILIRDLESTPTYFSTGTSRAILANRISYCFDWHGPSMTIDTACSSSMVALHQSVKALRAGEARVAVAGGTELLLGPEQFVGESKMNLLSPTGRSRMWDADADGYARGDGVAAVILKRLSDAIADGDHIESIIRDTGVNQDGKSTGLTVPSSEAQAALIRSTYARAGLDLSNPDDWPQFFEAHGTGTKVGDPREAAAISGCFGSQPIHGNPLYVGSIKTIIGHTEGTAGLAGVLKASLAIQHGVIPPNMLLNRLNPDVKQYYTNLQIPTSPIQWPVLPAGVPRRASVNSFGFGGTNGHAIIEGYEPKASNFDGEQQQPVAPVTSFVFSATTEESLVALLQSYSNYLKINPTIDLHSLAWTLQSRRSAFAYKTAVAASTIDGLVSRLESKVKQAKSTPPTPAGVRSTPATPHLLGVFTGQGAQWPTMGAHLIQISATVRAKLEQLDHSLATLPEADRPSWRIADQLLAPKGESRLSEAALSQPLCTAVQVVLVDLLRSAGITFDAVVGHSSGEIGAAYAAGFISAADAIRIAYYRGVHAKLAQGQKGQKGAMLAVGTSWEDAQELIDLPAFAGKIRIAAHNSAASLTLSGDADAIAHAKRVFDEEKKFARLLLVDTAYHSHHMLPCSGPYIESLRACQIQVNKDRDSSCTWFSSVRADGKPMVADEELQDVYWSDNMVNTVLFADAVKRAAANESLNLAIEVGPHPALKGPAQQNISDVRPSSPLPYTGLLNRGNSDVEAFSDALGSVWTYLGPGTVDFQSYTRLVTPAAPAPKLLTGLPSYQFSRDRVHWHESRRAKKMRRRGAAFHELLGVPSPDNTDQDLRWTNFLKSSEIPWLDGHKLQGQTVFPAAGYVAMALEAGKWLAGDRSVQVLEVRNLTIDRAITFDDGAGFAVETLVALTGISPMSAAKNNSSSSSQMADFAVYACPNTGSLGLELVSSGQVHIVYGAPSFSVLASTPLDDSNMTSIDCEQFYSTLSGLGYGYNGPFHTLAETKRRLGQASATVATYAYSDDERPLIVHPTMLDVAFQASFLAQTSPGDEQLWSLHVPTSIKCVRINPELSASLPTASVELPLSAVLHEPESISLHSSVDVFTENKRETLLQVEGLIMKPFSPATAADDRPMFSTMEYGVAVPNAGVATGHEHPTDKEVVLAGVCDRVAYYYLRAWEAKAGDEEERFRHLLSTFVGGQHSSMTEAWSSDEEKDIQALISQYPESTDLQLLATLGDSFSTETLAQPLLDECFSRGVGFARASAGLARTVQQISHRYPHAKIVEIGAGRGHTTETVLSAIGDAFSSYTFTDTSDDIFGTVAETFQAHGKKIDYKAFNPAKAPSAQGFTEHSYDVAILPNSIYTSSSLQTALGNIRRLLKPGGYLVASAITHEPVRVQALLAGVSLSSDDPRASVSTWHSALRNAGFSGIDTISAEADRRVWPVSVLTAQAINDRTQLLRKPLSSFKGGFRLHEVVILAGKSWESSRLAEEISDLAGRFCDKVTVLEELPTDDDEISPMATFISLLDLSEPVFEEMSEEKMEGLKCLFELSKNILWVTHNARAGSPYHYASIGFGRSIAYEMPHLMLQFLDLDEVEDVVASSRVITESVVRLAALVEWEDKEMLWSLEPELYVEKGQVLVPRIRPNDEQNARINSLRRPVSEVVDPRQGTVRVVPQAGDGASLVLRKEPWDSSPLAMQIRQSTLHALAVTGESMLFVGIGTKEATGETVIALSSTNASRSVPLVSLPTNIADLDQSAGLLASTANHLLAASILASIPANGHLLLHEPAPDGSLASALASQAAEKNVRVTFSTNSATTGDATWIKLNPWTPEHLLKQQLPAGLTHFMDLASPESQVRKYLPLGCRPISVHDLARAQATNHSPGDDRTALLESLKGAVSRAITATATTASGSTAQTAVFPSQIRDLELPSSPVSIIDWTVEATVPAEVRPLDATRYFSRDRTYLLVGLAGQLGQSICEWMARHGAGTVCLTSRSAKADPEWQAAMQKLGTTVRFDVLDVTKREQVEKLVSELGTTCSPIAGVINGAAVFNDMLFSEMSLEVMERVTQPKIIGTKNLNEVFGTTPLDFFVVLSSLTSVIGNSGQTNYTAANAYMTGLVGERRSRGLTGSSLEIGRVAGIGYMERAGDIAREQLIRFGFMAISETDLHQLLAEAIHAGAPSSALAPVVTTGCRTARDDEEVPVAWFHDPRFSHKVIEAREQGSASEGKKSALPVQEQLAQATSKDEAFKVLKDCFAAKLAMISRLSDDQVGHNIPLVELGIDSLVAVEVRGWFLKELKTDMPVLKVLGGGSVADLWGSVAASPATVSKPAAAPPAPKSEDSSASSAGPSSGSRSPLETPSTPPVGEEAKQVNLSEAAERAAKFQEGKQPDSPAYVKSELVSFAQSRFWFLRLLIEDQTTFNVCFYYRITGNLRVGDLERAVRLVTNRHESLRTCFVADEKEADLAHQKVLRQSVVRLERKKIDRLEELHAEYAAMKTIPFDIASGKTLRLILLTLSPTENYLLFNYHHILMDGVSLQNFLTDLEKAYQRQPLGPPPRQLPDFSRSQRAAFQQGKMNEEVTYWRQQFPDGHHPVLPLLPVAKVNTRAPMKAFNVNQVQYRLSKTLVNQVKERAKAHRSTTFHFYLAVFRAMLFRFTEAKDLTIGIADANRNDSDVMGTIGLLLNLLTLRFQNESTQSFGDCLAESRDKAYEALHHSRVPFDVLLKELNVPRSASYSPFFQAFFDYRQGHQEKQQFGNTELEMVELHPGRTAYDMTLDITDSSDSALILFRTQAGLYNPTATQLLLDTYVHLLETFAENTSLDLGNVSLFSDEQRKRAVDVGRGLDLKSAWPETLPLRIDQIAATNRDRIALKDGHGRILTYAVMINRIEAIAEELQKSGVQEGHRVLVFEDATADWPCSMLAIMRLGAVYVPLDLRNPLPRLADVAANCEPAAILVDNTTAKDIDQVNVTQAKVVNVSHASVKPNKRVPNVSRGDAVAAILYTSGSTGKPKGIVVKHSGLRNEIEGYTTQWGLRAERALQQSAFTFNHSSDQIYTGLTNGGTVYIVPWSKRGDPIEVSQIIQEEGITYTKATPAEYALWLDYGNANLRKATNWRFGFGGGESLTPALLHQLAALGLPHLRFFNSYGPTEISISSTKMEIAYREKQPEGRIPCGYSLPNYAAYILDEQQKPLPVGMPGELWIGGAGVSLGYLNNPELTDYHFYPDPYATTEYLAQGWTRMYRTGDIAHLQADGAMVFHSRVAGDAQVKIRGLRIELGDIESNIVKTSDGALREAVVTLRDGDPPLLVAHVVFAPNHNITDTEAFLDHLLQHLPVPQYMVPVMAIPLDRMPLSNHSKVDRKALKALPLPRRTVSSDAVDVLSETMLQLRRRMGRGPPHGGTRPADCPIDQLLHHRGKLPSRRPPTIPHPTPVQRDGAAGRPPRSQQSQRHGQTDRRKHYSQRNRLEARIRTSTRFDGTLSLHYLRPTSP" }, { "InterPro": [ { "InterPro-ID": "IPR029068", "InterPro-Name": "Glyas_Bleomycin-R_OHBP_Dase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1, "End": 123 }, { "InterPro-ID": "IPR029068", "InterPro-Name": "Glyas_Bleomycin-R_OHBP_Dase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 6, "End": 117 }, { "InterPro-ID": "IPR052393", "InterPro-Name": "Cadmium-induced_rsp", "InterPro-Type": "FAMILY", "Beg": 1, "End": 151 }, { "InterPro-ID": "IPR049789", "InterPro-Name": "YqcK/CadI-like", "InterPro-Type": "FAMILY", "Beg": 3, "End": 151 }, { "InterPro-ID": "IPR037523", "InterPro-Name": "VOC", "InterPro-Type": "DOMAIN", "Beg": 2, "End": 118 }, { "InterPro-ID": "IPR004360", "InterPro-Name": "Glyas_Fos-R_dOase_dom", "InterPro-Type": "DOMAIN", "Beg": 5, "End": 115 } ], "response#1": "MSRVQLALRVPDLEASIGFYSKLFGTGPAKVRPGYANFAIAEPPLKLVLIEGAGEDATRLDHLGVEVEDSAQVGHAARRLKESGLATVEENDTACCYAVQDKVWVTGPGGEPWEVYVVKGDADTLAKADDSACCTPRDSGSAGAAVGADCC", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more VOC, Glyas_Fos-R_dOase_dom that are essential for its biological function; 2. The protein should belong to Cadmium-induced_rsp, YqcK/CadI-like that shares evolutionary origin and functional similarity; 3. The protein should be classified within Glyas_Bleomycin-R_OHBP_Dase, Glyas_Bleomycin-R_OHBP_Dase sharing conserved structural features. The designed protein sequence is ", "reference": "MSRVQLALRVPDLEASIGFYSKLFGTGPAKVRPGYANFAIAEPPLKLVLIEGAGEDATRLDHLGVEVEDSAQVGHAARRLKESGLATVEENDTACCYAVQDKVWVTGPGGEPWEVYVVKGDADTLAKADDSACCTPRDSGSAGAAVGADCC" }, { "InterPro": [ { "InterPro-ID": "IPR011055", "InterPro-Name": "Dup_hybrid_motif", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 138, "End": 385 }, { "InterPro-ID": "IPR045834", "InterPro-Name": "Csd3_N2", "InterPro-Type": "DOMAIN", "Beg": 155, "End": 278 }, { "InterPro-ID": "IPR050570", "InterPro-Name": "Cell_wall_metabolism_enzyme", "InterPro-Type": "FAMILY", "Beg": 10, "End": 386 }, { "InterPro-ID": "IPR016047", "InterPro-Name": "Peptidase_M23", "InterPro-Type": "DOMAIN", "Beg": 290, "End": 383 }, { "InterPro-ID": "IPR011055", "InterPro-Name": "Dup_hybrid_motif", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 259, "End": 390 }, { "InterPro-ID": "IPR007340", "InterPro-Name": "LysM_Opacity-associatedA", "InterPro-Type": "DOMAIN", "Beg": 68, "End": 148 } ], "response#1": "MGQFRFLALIVAVLCFSVALFLPTADEPDQDSYSVPLNQSVNTSQPPSSEMVPSDIRLTPLPQPKRIHYMVKVGDTLSGIFAQLGVPYSILQKILSVDLDHLQLDMIQPGEELELMMDDMGQLSRLIYHMSIVEKAIYTRENDGSFSYDFQEISGEWREILFSGEINGSFSVSARRVGLTSSQVANITQVMKDKIDFSRSLRAGDRFDILVKQQYLGEHNTGNSEIKAISFKLAKGDVSAFLAEDGRFYDRAGNSLERAFNRYPVDKAYRQITSGFNPKRKHPVTGRVVPHNGTDFATPIGAPVYSTGDGKVIVVRKHPYAGNYLVIEHNSVYKTRYLHLDKILVKKGQLVKRGQKIALAGATGRLTGPHLHFEVLVRNRPVDAMKADLPIAKSLSSNQKTSFLARVSEFDHLVQANQQEVALDET", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Csd3_N2, Peptidase_M23, LysM_Opacity-associatedA that are essential for its biological function; 2. The protein should belong to Cell_wall_metabolism_enzyme that shares evolutionary origin and functional similarity; 3. The protein should be classified within Dup_hybrid_motif, Dup_hybrid_motif sharing conserved structural features. The designed protein sequence is ", "reference": "MGQFRFLALIVAVLCFSVALFLPTADEPDQDSYSVPLNQSVNTSQPPSSEMVPSDIRLTPLPQPKRIHYMVKVGDTLSGIFAQLGVPYSILQKILSVDLDHLQLDMIQPGEELELMMDDMGQLSRLIYHMSIVEKAIYTRENDGSFSYDFQEISGEWREILFSGEINGSFSVSARRVGLTSSQVANITQVMKDKIDFSRSLRAGDRFDILVKQQYLGEHNTGNSEIKAISFKLAKGDVSAFLAEDGRFYDRAGNSLERAFNRYPVDKAYRQITSGFNPKRKHPVTGRVVPHNGTDFATPIGAPVYSTGDGKVIVVRKHPYAGNYLVIEHNSVYKTRYLHLDKILVKKGQLVKRGQKIALAGATGRLTGPHLHFEVLVRNRPVDAMKADLPIAKSLSSNQKTSFLARVSEFDHLVQANQQEVALDET" }, { "InterPro": [ { "InterPro-ID": "IPR038904", "InterPro-Name": "BRAT1", "InterPro-Type": "FAMILY", "Beg": 1, "End": 974 }, { "InterPro-ID": "IPR011989", "InterPro-Name": "ARM-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 426, "End": 820 }, { "InterPro-ID": "IPR016024", "InterPro-Name": "ARM-type_fold", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 503, "End": 837 } ], "response#1": "MQKQEETLSRLRTIFDIFLRENFSTTNNVYFEKLLTHLQAKENAFVLQAPFVVEWVDRCITAVTEDFKKIHPKVISFMLNLTSFLANNEWMIVRLRELDIVNRAVKLLQREHNLSPSIKLGGIRLMKAITVYSMGLAFLRMHRIWTLLIQYSNNDHTLYVVREARQVLYNMVYKSCDKLHDKAVTLEILSEIMQPIHDNLYKNTDGVERIHVKVDDNEMLHKISSTLDLLSYILQQTLVLEERTTLIILLKEHHDFEITVWKLIDMTHNPYFTEKIFTTLSSYNFALLLHEKLLNPNATEPSEEFTEFGLAFFNLMKFLITRKDGLSFVKLAELNHVLWKKLGPRAPKEIVIQQERVTFENQLICFHMLPLLFSMKYAQKIADEESKIELFDAYVVKLLEISCEQTLRLCYTMRDNFFSADGMAVGLVTAGLANKCIHSLLALENVLDREQAVTVCQALLYVLREAVAMSVITNNGEDDCHSVSSAGSSYLKLYPRGTEQVVNDPQVLHSVMVGLRTLIERFKITWKESVETIGLVNCLAFVLENTSMDARCTVQALKLVQLAVEHFLSPNMALLVDNLQGSALVCLGPIIVKRMHDTMWEVRDTTLELTTSIASISRIKFPAFQRFLIDSKIPPIVYEMAKNDSEVYVRASAFQCLSQMVSINLLWENGLSQLDLVDHLLFVMYRETNDIVRSEAVITLMKIYEHRKIHEKYKNTLFSTLNYCVIGDHHTEVKLNALNFWRREFYRQFSNQGMIDGSFPTVTFSKEQKKIVTLTEKEIQTSIAKVFGEVQQYGYFGILLKCLREETSMEVLEFLIKGVKTMTEKFERYKGIMEEIEMRSPLSDRERPRFDFPSQPQPTPIPQQPPVNPTEADEVIESILNSQDAQLLEKAFETQMQINAQGKTAEKRHIDEFYYKQFAVPLRQFFEELKTIDLDQLVKQHQEWFECKENFTSLLDDILGALKRDDENMISDCY", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to BRAT1 that shares evolutionary origin and functional similarity; 2. The protein should be classified within ARM-like, ARM-type_fold sharing conserved structural features. The designed protein sequence is ", "reference": "MQKQEETLSRLRTIFDIFLRENFSTTNNVYFEKLLTHLQAKENAFVLQAPFVVEWVDRCITAVTEDFKKIHPKVISFMLNLTSFLANNEWMIVRLRELDIVNRAVKLLQREHNLSPSIKLGGIRLMKAITVYSMGLAFLRMHRIWTLLIQYSNNDHTLYVVREARQVLYNMVYKSCDKLHDKAVTLEILSEIMQPIHDNLYKNTDGVERIHVKVDDNEMLHKISSTLDLLSYILQQTLVLEERTTLIILLKEHHDFEITVWKLIDMTHNPYFTEKIFTTLSSYNFALLLHEKLLNPNATEPSEEFTEFGLAFFNLMKFLITRKDGLSFVKLAELNHVLWKKLGPRAPKEIVIQQERVTFENQLICFHMLPLLFSMKYAQKIADEESKIELFDAYVVKLLEISCEQTLRLCYTMRDNFFSADGMAVGLVTAGLANKCIHSLLALENVLDREQAVTVCQALLYVLREAVAMSVITNNGEDDCHSVSSAGSSYLKLYPRGTEQVVNDPQVLHSVMVGLRTLIERFKITWKESVETIGLVNCLAFVLENTSMDARCTVQALKLVQLAVEHFLSPNMALLVDNLQGSALVCLGPIIVKRMHDTMWEVRDTTLELTTSIASISRIKFPAFQRFLIDSKIPPIVYEMAKNDSEVYVRASAFQCLSQMVSINLLWENGLSQLDLVDHLLFVMYRETNDIVRSEAVITLMKIYEHRKIHEKYKNTLFSTLNYCVIGDHHTEVKLNALNFWRREFYRQFSNQGMIDGSFPTVTFSKEQKKIVTLTEKEIQTSIAKVFGEVQQYGYFGILLKCLREETSMEVLEFLIKGVKTMTEKFERYKGIMEEIEMRSPLSDRERPRFDFPSQPQPTPIPQQPPVNPTEADEVIESILNSQDAQLLEKAFETQMQINAQGKTAEKRHIDEFYYKQFAVPLRQFFEELKTIDLDQLVKQHQEWFECKENFTSLLDDILGALKRDDENMISDCY" }, { "InterPro": [ { "InterPro-ID": "IPR052370", "InterPro-Name": "Meta-cleavage_hydrolase", "InterPro-Type": "FAMILY", "Beg": 18, "End": 262 }, { "InterPro-ID": "IPR029058", "InterPro-Name": "AB_hydrolase_fold", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1, "End": 261 }, { "InterPro-ID": "IPR000073", "InterPro-Name": "AB_hydrolase_1", "InterPro-Type": "DOMAIN", "Beg": 22, "End": 252 }, { "InterPro-ID": "IPR000073", "InterPro-Name": "AB_hydrolase_1", "InterPro-Type": "DOMAIN", "Beg": 46, "End": 61 }, { "InterPro-ID": "IPR000073", "InterPro-Name": "AB_hydrolase_1", "InterPro-Type": "DOMAIN", "Beg": 207, "End": 221 }, { "InterPro-ID": "IPR000073", "InterPro-Name": "AB_hydrolase_1", "InterPro-Type": "DOMAIN", "Beg": 90, "End": 103 }, { "InterPro-ID": "IPR000073", "InterPro-Name": "AB_hydrolase_1", "InterPro-Type": "DOMAIN", "Beg": 104, "End": 117 }, { "InterPro-ID": "IPR029058", "InterPro-Name": "AB_hydrolase_fold", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1, "End": 260 } ], "response#1": "MNKVKVGDAQVSYCIDGKGPGLVLVHGTGGDSETNWGHLMPALTNDWTVVRPDYSGSGITSDEGKQLEVKEIAAQVVAAAEAARVVPFDLVGFSLGSAVVIAIAADYPHLVRRIVLLGAFLSSRDIRQKTQFELWRDLIRTDRAALSRLILLTGFSPDFISKQGHDGVSVIINSFVSEINWEGMARQVELDLSIDVSEAARRIEKPTLVIGCSHDHIVPSSQAKSVVRIIRGAQYTELHTGHLAHIENPEEFILLLRSFLLSEDVP", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more AB_hydrolase_1, AB_hydrolase_1, AB_hydrolase_1, AB_hydrolase_1, AB_hydrolase_1 that are essential for its biological function; 2. The protein should belong to Meta-cleavage_hydrolase that shares evolutionary origin and functional similarity; 3. The protein should be classified within AB_hydrolase_fold, AB_hydrolase_fold sharing conserved structural features. The designed protein sequence is ", "reference": "MNKVKVGDAQVSYCIDGKGPGLVLVHGTGGDSETNWGHLMPALTNDWTVVRPDYSGSGITSDEGKQLEVKEIAAQVVAAAEAARVVPFDLVGFSLGSAVVIAIAADYPHLVRRIVLLGAFLSSRDIRQKTQFELWRDLIRTDRAALSRLILLTGFSPDFISKQGHDGVSVIINSFVSEINWEGMARQVELDLSIDVSEAARRIEKPTLVIGCSHDHIVPSSQAKSVVRIIRGAQYTELHTGHLAHIENPEEFILLLRSFLLSEDVP" }, { "InterPro": [ { "InterPro-ID": "IPR028090", "InterPro-Name": "JAB_dom_prok", "InterPro-Type": "DOMAIN", "Beg": 23, "End": 118 } ], "response#1": "MNFSIKATIRAWSAPEHKLACRKQLWRKIVAELERRGKRRHEAGTFLLGIERNGRKEVQSAVYYDDLDPSAYDSGVCILHGDAFAKLWSHCREKGLTVVADVHTHPGAGFQSDSDRTNPMVARQGHIAIILPNFARWPIRQGNLGIYEYCGQHEWLERSPAHAPNFFYTGFWS", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more JAB_dom_prok that are essential for its biological function. The designed protein sequence is ", "reference": "MNFSIKATIRAWSAPEHKLACRKQLWRKIVAELERRGKRRHEAGTFLLGIERNGRKEVQSAVYYDDLDPSAYDSGVCILHGDAFAKLWSHCREKGLTVVADVHTHPGAGFQSDSDRTNPMVARQGHIAIILPNFARWPIRQGNLGIYEYCGQHEWLERSPAHAPNFFYTGFWS" }, { "InterPro": [ { "InterPro-ID": "IPR013149", "InterPro-Name": "ADH-like_C", "InterPro-Type": "DOMAIN", "Beg": 259, "End": 387 }, { "InterPro-ID": "IPR013154", "InterPro-Name": "ADH-like_N", "InterPro-Type": "DOMAIN", "Beg": 103, "End": 213 }, { "InterPro-ID": "IPR011032", "InterPro-Name": "GroES-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 79, "End": 244 }, { "InterPro-ID": "IPR036291", "InterPro-Name": "NAD(P)-bd_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 221, "End": 388 }, { "InterPro-ID": "IPR020843", "InterPro-Name": "PKS_ER", "InterPro-Type": "DOMAIN", "Beg": 85, "End": 424 }, { "InterPro-ID": "IPR002328", "InterPro-Name": "ADH_Zn_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 136, "End": 150 } ], "response#1": "MLEILADESVGGNSPTVIINRGAKKMQWPFIGCGGLGFSKTAHFTCFDSMTQLCEEDIPCIHLPPQHRSVYKMSTENKMRAVVFHSPYKVAVEERPIPKIQDSGDIVVKVTYTALCGSDLHTFRGIEPAGTGFVMGHEVTGEVVEVGSGVKSIQKGDMVVSAFTTSCGECFYCKQGFSSRCEKSVLFGCDHLDGAQAEYVRIPNADGTVMKAPEGVEEKYLVLMADIFPTGYFAASNAFKGYTPEQISEQTVVLIGCGPVGLCALINALEFKPKHLLAVDSIPSRLELARSLGAEPWNFQQDREGLDKRVKELTNGRGADAVIEVVGLSPALRTGFDLLRPWGTISSVGVHNGEIPWAGNDAYDKNLRIQMGRCPVRSVSPQALDVLKKNQHKLGFMADKIMPLSQAVEGYELFNAMKVQKVIFKAGE", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more ADH-like_C, ADH-like_N, PKS_ER that are essential for its biological function; 2. The protein should be classified within GroES-like_sf, NAD(P)-bd_dom_sf sharing conserved structural features; 3. The protein should contain ADH_Zn_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MLEILADESVGGNSPTVIINRGAKKMQWPFIGCGGLGFSKTAHFTCFDSMTQLCEEDIPCIHLPPQHRSVYKMSTENKMRAVVFHSPYKVAVEERPIPKIQDSGDIVVKVTYTALCGSDLHTFRGIEPAGTGFVMGHEVTGEVVEVGSGVKSIQKGDMVVSAFTTSCGECFYCKQGFSSRCEKSVLFGCDHLDGAQAEYVRIPNADGTVMKAPEGVEEKYLVLMADIFPTGYFAASNAFKGYTPEQISEQTVVLIGCGPVGLCALINALEFKPKHLLAVDSIPSRLELARSLGAEPWNFQQDREGLDKRVKELTNGRGADAVIEVVGLSPALRTGFDLLRPWGTISSVGVHNGEIPWAGNDAYDKNLRIQMGRCPVRSVSPQALDVLKKNQHKLGFMADKIMPLSQAVEGYELFNAMKVQKVIFKAGE" }, { "InterPro": [ { "InterPro-ID": "IPR020904", "InterPro-Name": "Sc_DH/Rdtase_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 141, "End": 169 }, { "InterPro-ID": "IPR002347", "InterPro-Name": "SDR_fam", "InterPro-Type": "FAMILY", "Beg": 154, "End": 173 }, { "InterPro-ID": "IPR002347", "InterPro-Name": "SDR_fam", "InterPro-Type": "FAMILY", "Beg": 134, "End": 142 }, { "InterPro-ID": "IPR002347", "InterPro-Name": "SDR_fam", "InterPro-Type": "FAMILY", "Beg": 81, "End": 92 }, { "InterPro-ID": "IPR002347", "InterPro-Name": "SDR_fam", "InterPro-Type": "FAMILY", "Beg": 19, "End": 249 }, { "InterPro-ID": "IPR002347", "InterPro-Name": "SDR_fam", "InterPro-Type": "FAMILY", "Beg": 175, "End": 192 }, { "InterPro-ID": "IPR002347", "InterPro-Name": "SDR_fam", "InterPro-Type": "FAMILY", "Beg": 11, "End": 28 }, { "InterPro-ID": "IPR002347", "InterPro-Name": "SDR_fam", "InterPro-Type": "FAMILY", "Beg": 214, "End": 234 }, { "InterPro-ID": "IPR002347", "InterPro-Name": "SDR_fam", "InterPro-Type": "FAMILY", "Beg": 128, "End": 144 }, { "InterPro-ID": "IPR036291", "InterPro-Name": "NAD(P)-bd_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 9, "End": 249 } ], "response#1": "MAAVGRYSGKVVVVTGGSRGIGAAIVRAFVDSGAQVVFCDKDEAGGRAVEQELLGTVFIPGDVTQEGDLQTLISETVSRFGHLDCVVNNAGYHPPAQLPEETSAQGFRQLLEENLLGAYTLIKLALPHLRKSKGNIINISSLVGAIGQSQALTYVATKGAVTAMTKALALDESRYGVRVNCISPGNIWTPLWQELAAATSDPRATILEGTLAQPLGRMGQPAEVGAAAVFLASEATFCTGLELFMTGGAELGYGRKASSSTLVEVPILPP", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to SDR_fam, SDR_fam, SDR_fam, SDR_fam, SDR_fam, SDR_fam, SDR_fam, SDR_fam that shares evolutionary origin and functional similarity; 2. The protein should be classified within NAD(P)-bd_dom_sf sharing conserved structural features; 3. The protein should contain Sc_DH/Rdtase_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MAAVGRYSGKVVVVTGGSRGIGAAIVRAFVDSGAQVVFCDKDEAGGRAVEQELLGTVFIPGDVTQEGDLQTLISETVSRFGHLDCVVNNAGYHPPAQLPEETSAQGFRQLLEENLLGAYTLIKLALPHLRKSKGNIINISSLVGAIGQSQALTYVATKGAVTAMTKALALDESRYGVRVNCISPGNIWTPLWQELAAATSDPRATILEGTLAQPLGRMGQPAEVGAAAVFLASEATFCTGLELFMTGGAELGYGRKASSSTLVEVPILPP" }, { "InterPro": [ { "InterPro-ID": "IPR036697", "InterPro-Name": "Hemocyanin_N_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 30, "End": 160 }, { "InterPro-ID": "IPR008922", "InterPro-Name": "Di-copper_centre_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 160, "End": 438 }, { "InterPro-ID": "IPR036697", "InterPro-Name": "Hemocyanin_N_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 24, "End": 156 }, { "InterPro-ID": "IPR013788", "InterPro-Name": "Hemocyanin/hexamerin", "InterPro-Type": "FAMILY", "Beg": 5, "End": 679 }, { "InterPro-ID": "IPR005204", "InterPro-Name": "Hemocyanin_N", "InterPro-Type": "DOMAIN", "Beg": 32, "End": 155 }, { "InterPro-ID": "IPR013788", "InterPro-Name": "Hemocyanin/hexamerin", "InterPro-Type": "FAMILY", "Beg": 413, "End": 421 }, { "InterPro-ID": "IPR008922", "InterPro-Name": "Di-copper_centre_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 161, "End": 436 }, { "InterPro-ID": "IPR000896", "InterPro-Name": "Hemocyanin/hexamerin_mid_dom", "InterPro-Type": "DOMAIN", "Beg": 161, "End": 431 }, { "InterPro-ID": "IPR014756", "InterPro-Name": "Ig_E-set", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 439, "End": 678 }, { "InterPro-ID": "IPR013788", "InterPro-Name": "Hemocyanin/hexamerin", "InterPro-Type": "FAMILY", "Beg": 220, "End": 233 }, { "InterPro-ID": "IPR013788", "InterPro-Name": "Hemocyanin/hexamerin", "InterPro-Type": "FAMILY", "Beg": 267, "End": 279 }, { "InterPro-ID": "IPR013788", "InterPro-Name": "Hemocyanin/hexamerin", "InterPro-Type": "FAMILY", "Beg": 416, "End": 431 }, { "InterPro-ID": "IPR013788", "InterPro-Name": "Hemocyanin/hexamerin", "InterPro-Type": "FAMILY", "Beg": 234, "End": 251 }, { "InterPro-ID": "IPR005203", "InterPro-Name": "Hemocyanin_C", "InterPro-Type": "DOMAIN", "Beg": 440, "End": 676 }, { "InterPro-ID": "IPR037020", "InterPro-Name": "Hemocyanin_C_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 439, "End": 685 } ], "response#1": "MLSKVVLLVALAAICGAQGASYAGRHTADMDFLHKQKKIFDLLLYVRQADLSDAEWYDVGRNYDMESNMDMYKDKNVVQKFLWWYKQGMFLSRNAIFTPLNSEQKYEVRMLFELLYNAKDFQTFYKTAAWARLRMNSGMFTTAFSIAVLYRPDTKYMKFPAIYEIYPNYFFDSSVIEEAQNLKMSRGSSVVTGMNNIETYIVNTNYSSKNMREYNDPEYKLDYFMEDVELNAYYYYMREMLPYWMSSSQYHMPKEIRGQLYYFLHKQLMTRYFLERMSNDLGKTAEFDWNKPINSGFYSTIMYSNGVTFPQRNRFSSLPYYKYKYLNVINALEMRLMDAIDSGYLIDEYGKKIDIYTPEGLNMLGNVIEGSSDSINTKFYGMYDILARDILGYNFDFQNKNNLIPSALQSYSTSMRDPAFYMLYQNILSYFLRYKKLQPQYSQSELQMPGVKFESVNIDKLYTYFDKCDTLINNAVAVENFKGGMYLRLKARRACMNYERFTYKININSDKETKGMMRIFLGPAFDEIKHDMVYLQKYFYLFMEMDRFAVTLRPGSNSIERQSSESPFTTSTIMPSDIFYDKLNKAIGGSEPFTYSEKMLGFPERLILPRGKPEGMRYKMFFFLSSMDESNTKSYEIPLYGKMTLDDKVFGFPLDRPMWAWNFTIPNMYFKDVFIYNRPNEESMNY", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Hemocyanin_N, Hemocyanin/hexamerin_mid_dom, Hemocyanin_C that are essential for its biological function; 2. The protein should belong to Hemocyanin/hexamerin, Hemocyanin/hexamerin, Hemocyanin/hexamerin, Hemocyanin/hexamerin, Hemocyanin/hexamerin, Hemocyanin/hexamerin that shares evolutionary origin and functional similarity; 3. The protein should be classified within Hemocyanin_N_sf, Di-copper_centre_dom_sf, Hemocyanin_N_sf, Di-copper_centre_dom_sf, Ig_E-set, Hemocyanin_C_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MLSKVVLLVALAAICGAQGASYAGRHTADMDFLHKQKKIFDLLLYVRQADLSDAEWYDVGRNYDMESNMDMYKDKNVVQKFLWWYKQGMFLSRNAIFTPLNSEQKYEVRMLFELLYNAKDFQTFYKTAAWARLRMNSGMFTTAFSIAVLYRPDTKYMKFPAIYEIYPNYFFDSSVIEEAQNLKMSRGSSVVTGMNNIETYIVNTNYSSKNMREYNDPEYKLDYFMEDVELNAYYYYMREMLPYWMSSSQYHMPKEIRGQLYYFLHKQLMTRYFLERMSNDLGKTAEFDWNKPINSGFYSTIMYSNGVTFPQRNRFSSLPYYKYKYLNVINALEMRLMDAIDSGYLIDEYGKKIDIYTPEGLNMLGNVIEGSSDSINTKFYGMYDILARDILGYNFDFQNKNNLIPSALQSYSTSMRDPAFYMLYQNILSYFLRYKKLQPQYSQSELQMPGVKFESVNIDKLYTYFDKCDTLINNAVAVENFKGGMYLRLKARRACMNYERFTYKININSDKETKGMMRIFLGPAFDEIKHDMVYLQKYFYLFMEMDRFAVTLRPGSNSIERQSSESPFTTSTIMPSDIFYDKLNKAIGGSEPFTYSEKMLGFPERLILPRGKPEGMRYKMFFFLSSMDESNTKSYEIPLYGKMTLDDKVFGFPLDRPMWAWNFTIPNMYFKDVFIYNRPNEESMNY" }, { "InterPro": [ { "InterPro-ID": "IPR017853", "InterPro-Name": "Glycoside_hydrolase_SF", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 282, "End": 587 }, { "InterPro-ID": "IPR006103", "InterPro-Name": "Glyco_hydro_2_cat", "InterPro-Type": "DOMAIN", "Beg": 282, "End": 589 }, { "InterPro-ID": "IPR006104", "InterPro-Name": "Glyco_hydro_2_N", "InterPro-Type": "DOMAIN", "Beg": 12, "End": 184 }, { "InterPro-ID": "IPR006101", "InterPro-Name": "Glyco_hydro_2", "InterPro-Type": "FAMILY", "Beg": 496, "End": 511 }, { "InterPro-ID": "IPR006101", "InterPro-Name": "Glyco_hydro_2", "InterPro-Type": "FAMILY", "Beg": 91, "End": 106 }, { "InterPro-ID": "IPR006101", "InterPro-Name": "Glyco_hydro_2", "InterPro-Type": "FAMILY", "Beg": 399, "End": 414 }, { "InterPro-ID": "IPR006101", "InterPro-Name": "Glyco_hydro_2", "InterPro-Type": "FAMILY", "Beg": 291, "End": 305 }, { "InterPro-ID": "IPR006101", "InterPro-Name": "Glyco_hydro_2", "InterPro-Type": "FAMILY", "Beg": 322, "End": 340 }, { "InterPro-ID": "IPR008979", "InterPro-Name": "Galactose-bd-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1, "End": 184 }, { "InterPro-ID": "IPR036156", "InterPro-Name": "Beta-gal/glucu_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 188, "End": 281 }, { "InterPro-ID": "IPR023232", "InterPro-Name": "Glyco_hydro_2_AS", "InterPro-Type": "ACTIVE_SITE", "Beg": 399, "End": 413 }, { "InterPro-ID": "IPR013783", "InterPro-Name": "Ig-like_fold", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 187, "End": 281 }, { "InterPro-ID": "IPR023230", "InterPro-Name": "Glyco_hydro_2_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 332, "End": 357 }, { "InterPro-ID": "IPR006102", "InterPro-Name": "Glyco_hydro_2_Ig-like", "InterPro-Type": "DOMAIN", "Beg": 188, "End": 280 } ], "response#1": "MLFPKDTLTREIKDLSGIWRFKADPDNRGREEKWHHQPLQDTIPMPVPASYNDITQDAALRDHIGDVWYEQTFIVPRSWSGDRMMLWIGSACHHAVVWVNGVEVASHKGGFLPFEADITRVAVPGRENRVTIVVNNVLNWQTLPPGRIKTFDDEKHPEGYRVQEYFHDFFNYAGLHRPVKLYRTSGLFIQDITITTDVQGESGVVGYSIECSQPEGEVRVKLLDEDGKEAATGKGSSGTLQVENARLWKPLQAYLYTLHVELLDSYGQLADHYQLQVGIRTVKVEGTRFLINGERFYFKGFGKHEDSDIRGKGLDQAVNVKDFNLLKWINANSFRTSHYPYAEELLELADREGIVVIGEVPAVGFTFFNYNDKVYTPDQANEETLAHHHDVLSDLIARDKNHPSVVMWSLANEAATFQDEAVPYFRQLADTARRLDPQRPITIVQWPLPDKCKVAQFFDVICVNRYYSWYQDPGALELVEHQVEWELTNWYRNFGKPVIMTEYGADAIAGFHQDPPVMFTEEYQEELLTRYHNVFDRLDFVIGEHVWAFADFATKQGITRINGNKKGVFTRQRQPKAAARMLRSRWGEMGEYPEKL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Glyco_hydro_2_cat, Glyco_hydro_2_N, Glyco_hydro_2_Ig-like that are essential for its biological function; 2. The protein should belong to Glyco_hydro_2, Glyco_hydro_2, Glyco_hydro_2, Glyco_hydro_2, Glyco_hydro_2 that shares evolutionary origin and functional similarity; 3. The protein should be classified within Glycoside_hydrolase_SF, Galactose-bd-like_sf, Beta-gal/glucu_dom_sf, Ig-like_fold sharing conserved structural features; 4. The protein should contain Glyco_hydro_2_CS that is preserved across related proteins; 5. The protein must have Glyco_hydro_2_AS that is conserved among related catalytic enzymes. The designed protein sequence is ", "reference": "MLFPKDTLTREIKDLSGIWRFKADPDNRGREEKWHHQPLQDTIPMPVPASYNDITQDAALRDHIGDVWYEQTFIVPRSWSGDRMMLWIGSACHHAVVWVNGVEVASHKGGFLPFEADITRVAVPGRENRVTIVVNNVLNWQTLPPGRIKTFDDEKHPEGYRVQEYFHDFFNYAGLHRPVKLYRTSGLFIQDITITTDVQGESGVVGYSIECSQPEGEVRVKLLDEDGKEAATGKGSSGTLQVENARLWKPLQAYLYTLHVELLDSYGQLADHYQLQVGIRTVKVEGTRFLINGERFYFKGFGKHEDSDIRGKGLDQAVNVKDFNLLKWINANSFRTSHYPYAEELLELADREGIVVIGEVPAVGFTFFNYNDKVYTPDQANEETLAHHHDVLSDLIARDKNHPSVVMWSLANEAATFQDEAVPYFRQLADTARRLDPQRPITIVQWPLPDKCKVAQFFDVICVNRYYSWYQDPGALELVEHQVEWELTNWYRNFGKPVIMTEYGADAIAGFHQDPPVMFTEEYQEELLTRYHNVFDRLDFVIGEHVWAFADFATKQGITRINGNKKGVFTRQRQPKAAARMLRSRWGEMGEYPEKL" }, { "InterPro": [ { "InterPro-ID": "IPR023355", "InterPro-Name": "Myo_ane_neurotoxin_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 28, "End": 74 } ], "response#1": "MNHLIILVVAAVFLGMASAEDVFHKRFTVSCLCASDGPSVHGNKLTGTVAVGGCNPGWHKCNTEHNVLYECCKKN", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should be classified within Myo_ane_neurotoxin_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MNHLIILVVAAVFLGMASAEDVFHKRFTVSCLCASDGPSVHGNKLTGTVAVGGCNPGWHKCNTEHNVLYECCKKN" }, { "InterPro": [ { "InterPro-ID": "IPR004404", "InterPro-Name": "DihydroxyA_deHydtase", "InterPro-Type": "FAMILY", "Beg": 53, "End": 593 }, { "InterPro-ID": "IPR050165", "InterPro-Name": "DHAD_IlvD/Edd", "InterPro-Type": "FAMILY", "Beg": 33, "End": 593 }, { "InterPro-ID": "IPR056740", "InterPro-Name": "ILV_EDD_C", "InterPro-Type": "DOMAIN", "Beg": 399, "End": 590 }, { "InterPro-ID": "IPR004404", "InterPro-Name": "DihydroxyA_deHydtase", "InterPro-Type": "FAMILY", "Beg": 39, "End": 593 }, { "InterPro-ID": "IPR020558", "InterPro-Name": "DiOHA_6PGluconate_deHydtase_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 501, "End": 512 }, { "InterPro-ID": "IPR020558", "InterPro-Name": "DiOHA_6PGluconate_deHydtase_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 157, "End": 167 }, { "InterPro-ID": "IPR042096", "InterPro-Name": "Dihydro-acid_dehy_C", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 413, "End": 564 }, { "InterPro-ID": "IPR000581", "InterPro-Name": "ILV_EDD_N", "InterPro-Type": "DOMAIN", "Beg": 69, "End": 387 }, { "InterPro-ID": "IPR037237", "InterPro-Name": "IlvD/EDD_N", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 29, "End": 412 } ], "response#1": "MATSSIRSRALGLSRRARFETTRLPFIGRRYKSDETLNRISSKITQPKSQGASQAMLYATGLTEEDMSKAQVGISSVWFEGNPCNMHLNDLSGIVRDSVLRAGLVPMRFNSVGVSDGISMGTAGMRYSLQSRELIADGIETVMNAQWYDANISLPGCDKNMPGVLMAMGRTNRPSIMVYGGSIKPGCSAKGQKLDLVSAFQSYGQFITGQIDETERFDIIRNACPGKGACGGMYTANTLATAIETMGMTVPGSSSCPADDPKKLVECENIGEVVKNMLREEIKPRDVMTRQAFENAMIVVNVLGGSTNAVLHLIAIADSVGIKLTIDDFQAVSDKTPFLADLKPSGKYLMNDLYSIGGTPALLKYLLKEGLIDGSGITVTGKTMKENVASWPDFPADQDIIQPLSNPIKPSGHLQILRGSLAPGGSVGKITGKEGLRFEGTAKCYDYEDAFIESLERGEIKKGEKTVVIIRYEGPKGGPGMPEMLKPSAAIMGAGLGQDVALLTDGRFSGGSHGFLIGHIVPEAMEGGPIALARDGDRIVIDAEEKVVDLDVPTEELDARRKQWKAPPLRYQKGTLKKYCALVSDASHGCVTDGPI", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more ILV_EDD_C, ILV_EDD_N that are essential for its biological function; 2. The protein should belong to DihydroxyA_deHydtase, DHAD_IlvD/Edd, DihydroxyA_deHydtase that shares evolutionary origin and functional similarity; 3. The protein should be classified within Dihydro-acid_dehy_C, IlvD/EDD_N sharing conserved structural features; 4. The protein should contain DiOHA_6PGluconate_deHydtase_CS, DiOHA_6PGluconate_deHydtase_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MATSSIRSRALGLSRRARFETTRLPFIGRRYKSDETLNRISSKITQPKSQGASQAMLYATGLTEEDMSKAQVGISSVWFEGNPCNMHLNDLSGIVRDSVLRAGLVPMRFNSVGVSDGISMGTAGMRYSLQSRELIADGIETVMNAQWYDANISLPGCDKNMPGVLMAMGRTNRPSIMVYGGSIKPGCSAKGQKLDLVSAFQSYGQFITGQIDETERFDIIRNACPGKGACGGMYTANTLATAIETMGMTVPGSSSCPADDPKKLVECENIGEVVKNMLREEIKPRDVMTRQAFENAMIVVNVLGGSTNAVLHLIAIADSVGIKLTIDDFQAVSDKTPFLADLKPSGKYLMNDLYSIGGTPALLKYLLKEGLIDGSGITVTGKTMKENVASWPDFPADQDIIQPLSNPIKPSGHLQILRGSLAPGGSVGKITGKEGLRFEGTAKCYDYEDAFIESLERGEIKKGEKTVVIIRYEGPKGGPGMPEMLKPSAAIMGAGLGQDVALLTDGRFSGGSHGFLIGHIVPEAMEGGPIALARDGDRIVIDAEEKVVDLDVPTEELDARRKQWKAPPLRYQKGTLKKYCALVSDASHGCVTDGPI" }, { "InterPro": [ { "InterPro-ID": "IPR011013", "InterPro-Name": "Gal_mutarotase_sf_dom", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 7, "End": 262 }, { "InterPro-ID": "IPR008928", "InterPro-Name": "6-hairpin_glycosidase_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 273, "End": 766 }, { "InterPro-ID": "IPR037018", "InterPro-Name": "Glyco_hydro_65_N_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 6, "End": 293 }, { "InterPro-ID": "IPR052047", "InterPro-Name": "GH94_Enzymes", "InterPro-Type": "FAMILY", "Beg": 5, "End": 768 }, { "InterPro-ID": "IPR033432", "InterPro-Name": "GH36_catalytic", "InterPro-Type": "DOMAIN", "Beg": 290, "End": 692 }, { "InterPro-ID": "IPR012341", "InterPro-Name": "6hp_glycosidase-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 305, "End": 689 }, { "InterPro-ID": "IPR010383", "InterPro-Name": "Glyco_hydrolase_94", "InterPro-Type": "DOMAIN", "Beg": 25, "End": 260 }, { "InterPro-ID": "IPR009342", "InterPro-Name": "Carb-bd_put_dom", "InterPro-Type": "DOMAIN", "Beg": 5, "End": 68 } ], "response#1": "MNRSDAYGYFRNQGREYVITTPRTPARWFNYLFNDTYYTEISQTGQGDSVAFRPHNRTLTRGFRYFYLKDLETGGTWSPLYQPLKTEPEAYECIHSLGTTEIRSVSQEIASSIHVFVPRAGQQEIWTVTLTNTGVKPRSLSLFTAFSLENGGVMGSKCQFDQESQILSSYSFPYHVTYGQKAGCDDHTNVVYVYPDYPADSYDCSQRAFFGGDDIYELPAAVQKGRCSGGQAEAENPLGALQQTITLEPGEQAVRHFVVGCASSLEEIRSSKAELAAKGYAVLLQETEDYWEGITGMFRVETPDDDVNAFMNIWLKKQIVMQTRTNRMSSYCPVRNQLQDALGYALVDPAGAAEYMISVLQGQERSGFIQQWIMTDGSPPKNLCLLKHTDGPVWLIICITALLNQCGDTELLQRQVGFKGSSDSATIYQHLLLAADYMAGETGAHGLCLMGDGDWNDPINGPGRLGRGESAWNTMALVYAIQALIPFCEQLGDTENAEQLNTVARRLADAVNRICWDGGWYVAGFDDDGTPFGTAQDEEGKLFLNTQTWAIMSGIASGERLDQCLAAIDSLDTPFGPRLLEPPFSGWNPKWGRISLKLAGTTENGSVYCHASMFKAFADCIAGRGSEAWQTISRTLPTNPDNPPGQNGQVPIFVPNYYFGLADSPNFGKSSHHVSTGTVGWMLWTTLEYALGIRATANGLKIDPCIPADWPEYTVERKYRSASYRIHVLNPSGISRGTVKVTVDGEAWMAAALPYEAGREYQVTVQLEQ", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more GH36_catalytic, Glyco_hydrolase_94, Carb-bd_put_dom that are essential for its biological function; 2. The protein should belong to GH94_Enzymes that shares evolutionary origin and functional similarity; 3. The protein should be classified within Gal_mutarotase_sf_dom, 6-hairpin_glycosidase_sf, Glyco_hydro_65_N_sf, 6hp_glycosidase-like_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MNRSDAYGYFRNQGREYVITTPRTPARWFNYLFNDTYYTEISQTGQGDSVAFRPHNRTLTRGFRYFYLKDLETGGTWSPLYQPLKTEPEAYECIHSLGTTEIRSVSQEIASSIHVFVPRAGQQEIWTVTLTNTGVKPRSLSLFTAFSLENGGVMGSKCQFDQESQILSSYSFPYHVTYGQKAGCDDHTNVVYVYPDYPADSYDCSQRAFFGGDDIYELPAAVQKGRCSGGQAEAENPLGALQQTITLEPGEQAVRHFVVGCASSLEEIRSSKAELAAKGYAVLLQETEDYWEGITGMFRVETPDDDVNAFMNIWLKKQIVMQTRTNRMSSYCPVRNQLQDALGYALVDPAGAAEYMISVLQGQERSGFIQQWIMTDGSPPKNLCLLKHTDGPVWLIICITALLNQCGDTELLQRQVGFKGSSDSATIYQHLLLAADYMAGETGAHGLCLMGDGDWNDPINGPGRLGRGESAWNTMALVYAIQALIPFCEQLGDTENAEQLNTVARRLADAVNRICWDGGWYVAGFDDDGTPFGTAQDEEGKLFLNTQTWAIMSGIASGERLDQCLAAIDSLDTPFGPRLLEPPFSGWNPKWGRISLKLAGTTENGSVYCHASMFKAFADCIAGRGSEAWQTISRTLPTNPDNPPGQNGQVPIFVPNYYFGLADSPNFGKSSHHVSTGTVGWMLWTTLEYALGIRATANGLKIDPCIPADWPEYTVERKYRSASYRIHVLNPSGISRGTVKVTVDGEAWMAAALPYEAGREYQVTVQLEQ" }, { "InterPro": [ { "InterPro-ID": "IPR001046", "InterPro-Name": "NRAMP_fam", "InterPro-Type": "FAMILY", "Beg": 232, "End": 682 }, { "InterPro-ID": "IPR001046", "InterPro-Name": "NRAMP_fam", "InterPro-Type": "FAMILY", "Beg": 286, "End": 630 }, { "InterPro-ID": "IPR001046", "InterPro-Name": "NRAMP_fam", "InterPro-Type": "FAMILY", "Beg": 387, "End": 408 }, { "InterPro-ID": "IPR001046", "InterPro-Name": "NRAMP_fam", "InterPro-Type": "FAMILY", "Beg": 362, "End": 381 }, { "InterPro-ID": "IPR001046", "InterPro-Name": "NRAMP_fam", "InterPro-Type": "FAMILY", "Beg": 600, "End": 619 }, { "InterPro-ID": "IPR001046", "InterPro-Name": "NRAMP_fam", "InterPro-Type": "FAMILY", "Beg": 436, "End": 459 }, { "InterPro-ID": "IPR001046", "InterPro-Name": "NRAMP_fam", "InterPro-Type": "FAMILY", "Beg": 541, "End": 560 }, { "InterPro-ID": "IPR001046", "InterPro-Name": "NRAMP_fam", "InterPro-Type": "FAMILY", "Beg": 334, "End": 360 } ], "response#1": "MHQDNSMRRAINQSRNGGSDSCDINNDREHDNINRNSYINNFHIENINSDKNEQSYIYCSDRAQVTDSILGNRKYTHEENINSTEMFSRTNYEYSNKNNVDIEMYNISNNNFYNGNNNGHSNDIIDYINNNNVNKDLSNTSNNADINTYIKKLTSNQSTAYCDGKGYNESANGSNFDINFRDVIKNNNNKNYKNNNHVPDDMLELGDRSFDSSFYIHNNVEEIDTERSNRLSFMSKLKMYFNYFGPGWIVAIAYLDPGNICGNLNVGLIRSDDFINVNSSVKDYTGYRLLWVLVYGHILGFIFHTLSMKLGHITGLDLAALCRKEFSSKFSYFLYICVQIAIWGAHLQAIIGVFVAINLILGIPVKIAILYTLIEAFAYSFLENKSLDLLEKVLSLLIGILVCCFMFNVFMTPINFQEVASSILYPRIPKGKLLDTMGLLGSVISAHIFYLHSNLTSKKKPVIYNDRMVKRYNKLGTIESGGSLLVSCITNCIIVLTFAEVNISGDDRKADYNLFNAYDVMKKYFGKTSMYIWSFGLLSSGNNASFMCEYASKSVFEGFLNKNVNPFFRVIFSRIILFIMLYAYVSYDKYTIDQLSNFINVVQILLLPLAIIPLYRFSIHKNVLGKFAIKGAFKYLVFVLVISIIVANFLLTLFDFLQYAPSNLYVIFIFISSIFYLLFIIYFFNMPITKTYYKDS", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to NRAMP_fam, NRAMP_fam, NRAMP_fam, NRAMP_fam, NRAMP_fam, NRAMP_fam, NRAMP_fam, NRAMP_fam that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MHQDNSMRRAINQSRNGGSDSCDINNDREHDNINRNSYINNFHIENINSDKNEQSYIYCSDRAQVTDSILGNRKYTHEENINSTEMFSRTNYEYSNKNNVDIEMYNISNNNFYNGNNNGHSNDIIDYINNNNVNKDLSNTSNNADINTYIKKLTSNQSTAYCDGKGYNESANGSNFDINFRDVIKNNNNKNYKNNNHVPDDMLELGDRSFDSSFYIHNNVEEIDTERSNRLSFMSKLKMYFNYFGPGWIVAIAYLDPGNICGNLNVGLIRSDDFINVNSSVKDYTGYRLLWVLVYGHILGFIFHTLSMKLGHITGLDLAALCRKEFSSKFSYFLYICVQIAIWGAHLQAIIGVFVAINLILGIPVKIAILYTLIEAFAYSFLENKSLDLLEKVLSLLIGILVCCFMFNVFMTPINFQEVASSILYPRIPKGKLLDTMGLLGSVISAHIFYLHSNLTSKKKPVIYNDRMVKRYNKLGTIESGGSLLVSCITNCIIVLTFAEVNISGDDRKADYNLFNAYDVMKKYFGKTSMYIWSFGLLSSGNNASFMCEYASKSVFEGFLNKNVNPFFRVIFSRIILFIMLYAYVSYDKYTIDQLSNFINVVQILLLPLAIIPLYRFSIHKNVLGKFAIKGAFKYLVFVLVISIIVANFLLTLFDFLQYAPSNLYVIFIFISSIFYLLFIIYFFNMPITKTYYKDS" }, { "InterPro": [ { "InterPro-ID": "IPR024652", "InterPro-Name": "Trichodiene_synth", "InterPro-Type": "FAMILY", "Beg": 5, "End": 377 }, { "InterPro-ID": "IPR008949", "InterPro-Name": "Isoprenoid_synthase_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 3, "End": 353 }, { "InterPro-ID": "IPR010458", "InterPro-Name": "TRI5_ascomyc", "InterPro-Type": "FAMILY", "Beg": 1, "End": 362 }, { "InterPro-ID": "IPR008949", "InterPro-Name": "Isoprenoid_synthase_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 3, "End": 349 }, { "InterPro-ID": "IPR024652", "InterPro-Name": "Trichodiene_synth", "InterPro-Type": "FAMILY", "Beg": 6, "End": 316 } ], "response#1": "MDMNTFPANTYCDSIVRFLDAIEYHDDNLTHDERVEGLRHVHSRTAQYFTEPLPRKVLKDVAPRRIAAVTRTISHFIVYCWSKLPREAQVDVSIYLSIINVLDDEISSEPSTQMATFWTDLVQGKQQKHPFWVLFNSHLPRLLRHYDSFCSFNIMRCTFDYFEGCWIEQHNFQGYPGADCYPLFLRRLNCLGGAVAGTIFPAAKFDEQKLFAEISCVMAQIDGPVALVNDLFSFYKEYDQDEANLVTNWCTVDGITMDQALTRLTDDTIHACVRILEILKDKDPDMLATIRGFIHGYVTWHICDFRYRLREIYDREDLGGSSAKFRDYFDTAINVGWVDVEEWTCQVQGFEVDGPVPKGSEIQAYRTNAFGFSVDTRRPHNMDYVGSSIISMFEWVTGYLKGKSR", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Trichodiene_synth, TRI5_ascomyc, Trichodiene_synth that shares evolutionary origin and functional similarity; 2. The protein should be classified within Isoprenoid_synthase_dom_sf, Isoprenoid_synthase_dom_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MDMNTFPANTYCDSIVRFLDAIEYHDDNLTHDERVEGLRHVHSRTAQYFTEPLPRKVLKDVAPRRIAAVTRTISHFIVYCWSKLPREAQVDVSIYLSIINVLDDEISSEPSTQMATFWTDLVQGKQQKHPFWVLFNSHLPRLLRHYDSFCSFNIMRCTFDYFEGCWIEQHNFQGYPGADCYPLFLRRLNCLGGAVAGTIFPAAKFDEQKLFAEISCVMAQIDGPVALVNDLFSFYKEYDQDEANLVTNWCTVDGITMDQALTRLTDDTIHACVRILEILKDKDPDMLATIRGFIHGYVTWHICDFRYRLREIYDREDLGGSSAKFRDYFDTAINVGWVDVEEWTCQVQGFEVDGPVPKGSEIQAYRTNAFGFSVDTRRPHNMDYVGSSIISMFEWVTGYLKGKSR" }, { "InterPro": [ { "InterPro-ID": "IPR035985", "InterPro-Name": "Ubiquitin-activating_enz", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 210, "End": 346 } ], "response#1": "MNLTLDHTTLHRAAKYFMDSGKAASHEAAMNLLQQFGLTIYVGEEIRSSAAHQIALLTIVNVTRRTLLGGVEVIGLPDCDSLTALAPNTGLKEAVMALGGTPVAVARPEWPTALIGSVEDYSNKDTAWRVTWEGWRAGAAPLMIGDRLSEDNSMALAPALAAAVCAGEVFSHYAGDHPMAGRRTAGLSLWQPGADWLDVDESEPELAFLPSNLWIIGLGNLGQAFAWLLALMPYETPQELQLVLQDYDRIAPSNDSTSLLSYKHDTNKMKARVVADWLDKRGFTTFIEERRFGPWTKRHADEPGVALCGVDNALARSALDQAGFPLIVEAGLGGGPQAFRSLGIHTFPSSRTAAEIWAKQVALADTSTEDMPAYQALKKSGIDACGLTQLASRTVGVPFVGLIAACLAMSELLRRLHGGKAFEFIAGSTATLQDIEFGTLHAPPYAHGYTRAMPMGWPTAP", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should be classified within Ubiquitin-activating_enz sharing conserved structural features. The designed protein sequence is ", "reference": "MNLTLDHTTLHRAAKYFMDSGKAASHEAAMNLLQQFGLTIYVGEEIRSSAAHQIALLTIVNVTRRTLLGGVEVIGLPDCDSLTALAPNTGLKEAVMALGGTPVAVARPEWPTALIGSVEDYSNKDTAWRVTWEGWRAGAAPLMIGDRLSEDNSMALAPALAAAVCAGEVFSHYAGDHPMAGRRTAGLSLWQPGADWLDVDESEPELAFLPSNLWIIGLGNLGQAFAWLLALMPYETPQELQLVLQDYDRIAPSNDSTSLLSYKHDTNKMKARVVADWLDKRGFTTFIEERRFGPWTKRHADEPGVALCGVDNALARSALDQAGFPLIVEAGLGGGPQAFRSLGIHTFPSSRTAAEIWAKQVALADTSTEDMPAYQALKKSGIDACGLTQLASRTVGVPFVGLIAACLAMSELLRRLHGGKAFEFIAGSTATLQDIEFGTLHAPPYAHGYTRAMPMGWPTAP" }, { "InterPro": [ { "InterPro-ID": "IPR056082", "InterPro-Name": "DUF7665", "InterPro-Type": "DOMAIN", "Beg": 7, "End": 157 } ], "response#1": "MISAPSPDHLLLEQDLATPEIRCGEIEERWRHIRTSWPHVFFAVSAPQRPNGPKEFGFRFEYTGYRQTPVTAQLWDLEADAPLPHAKWPTGTYVVPSVFRKDWQQGNCLYIPCDRISIQGHTAWLNDHPSRLWQPARGIICYLEQLYELFNQGDYTGLVSA", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more DUF7665 that are essential for its biological function. The designed protein sequence is ", "reference": "MISAPSPDHLLLEQDLATPEIRCGEIEERWRHIRTSWPHVFFAVSAPQRPNGPKEFGFRFEYTGYRQTPVTAQLWDLEADAPLPHAKWPTGTYVVPSVFRKDWQQGNCLYIPCDRISIQGHTAWLNDHPSRLWQPARGIICYLEQLYELFNQGDYTGLVSA" }, { "InterPro": [ { "InterPro-ID": "IPR000277", "InterPro-Name": "Cys/Met-Metab_PyrdxlP-dep_enz", "InterPro-Type": "FAMILY", "Beg": 9, "End": 389 }, { "InterPro-ID": "IPR015422", "InterPro-Name": "PyrdxlP-dep_Trfase_small", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 257, "End": 388 }, { "InterPro-ID": "IPR000277", "InterPro-Name": "Cys/Met-Metab_PyrdxlP-dep_enz", "InterPro-Type": "FAMILY", "Beg": 7, "End": 386 }, { "InterPro-ID": "IPR015424", "InterPro-Name": "PyrdxlP-dep_Trfase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 48, "End": 387 }, { "InterPro-ID": "IPR000277", "InterPro-Name": "Cys/Met-Metab_PyrdxlP-dep_enz", "InterPro-Type": "FAMILY", "Beg": 1, "End": 390 }, { "InterPro-ID": "IPR015421", "InterPro-Name": "PyrdxlP-dep_Trfase_major", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 2, "End": 256 } ], "response#1": "MNSMHPETLMVHGGMDGLTEAGVHVPAIDLSTTNPVNDVATGGDSYEWLATGHALKDGDSAVYQRLWQPGVARFETALAELEHADEAVAFATGMAAMTAALLAAVNAGTPHIVAVRPLYGGSDHLLETGLLGTTVTWAKEAEIASAIQDDTGLVIVETPANPSLDLVDLDSVVAAAGTVPVLVDNTFCTPVLQQPIRHGAALVLHSATKYLGGHGDAMGGIIATNSDWAMRLRQVRAITGALLHPMGAYLLHRGLRTLAVRMRAAQTTAGELAERLAAHPAITAVHYPGLNGQDPRGLLGRQMSGGGAMIALELAGGFDAARSFVEHCSLVVHAVSLGGADTLIQHPASLTHRPVAATAKPGDGLIRLSVGLEHVDDLEDDLIAALDASRAAA", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Cys/Met-Metab_PyrdxlP-dep_enz, Cys/Met-Metab_PyrdxlP-dep_enz, Cys/Met-Metab_PyrdxlP-dep_enz that shares evolutionary origin and functional similarity; 2. The protein should be classified within PyrdxlP-dep_Trfase_small, PyrdxlP-dep_Trfase, PyrdxlP-dep_Trfase_major sharing conserved structural features. The designed protein sequence is ", "reference": "MNSMHPETLMVHGGMDGLTEAGVHVPAIDLSTTNPVNDVATGGDSYEWLATGHALKDGDSAVYQRLWQPGVARFETALAELEHADEAVAFATGMAAMTAALLAAVNAGTPHIVAVRPLYGGSDHLLETGLLGTTVTWAKEAEIASAIQDDTGLVIVETPANPSLDLVDLDSVVAAAGTVPVLVDNTFCTPVLQQPIRHGAALVLHSATKYLGGHGDAMGGIIATNSDWAMRLRQVRAITGALLHPMGAYLLHRGLRTLAVRMRAAQTTAGELAERLAAHPAITAVHYPGLNGQDPRGLLGRQMSGGGAMIALELAGGFDAARSFVEHCSLVVHAVSLGGADTLIQHPASLTHRPVAATAKPGDGLIRLSVGLEHVDDLEDDLIAALDASRAAA" }, { "InterPro": [ { "InterPro-ID": "IPR017927", "InterPro-Name": "FAD-bd_FR_type", "InterPro-Type": "DOMAIN", "Beg": 25, "End": 131 }, { "InterPro-ID": "IPR039374", "InterPro-Name": "SIP_fam", "InterPro-Type": "FAMILY", "Beg": 69, "End": 252 }, { "InterPro-ID": "IPR013113", "InterPro-Name": "FAD-bd_9_SIP", "InterPro-Type": "DOMAIN", "Beg": 69, "End": 125 }, { "InterPro-ID": "IPR039261", "InterPro-Name": "FNR_nucleotide-bd", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 133, "End": 273 }, { "InterPro-ID": "IPR007037", "InterPro-Name": "SIP_C", "InterPro-Type": "DOMAIN", "Beg": 136, "End": 252 } ], "response#1": "MTKIAEKSKQEYGDLLKEKDHLQDMEQLEMTIVSIQTPYPSIVRIQGKINTLQPELWQAPNLAIRLIVSNPPEGQPISRVYTVRSFNPINAQIEIDFVKHEDLSPAMEWLNSAQVGTKIGLIGPRPHFIPNFTAKKHVVMFADDTAVPALYSILKQWELGISADIFIESFEKDIASQLPELEHVKIHSFHKEHHTSQKGLLLKAAFALEHYENITIWAACERNEARALRQFFLEDQQLNKNDVRIAGYWRDGVSSSELDKLRAQHYQEHIQQGKTLNEYDDLDLAN", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more FAD-bd_FR_type, FAD-bd_9_SIP, SIP_C that are essential for its biological function; 2. The protein should belong to SIP_fam that shares evolutionary origin and functional similarity; 3. The protein should be classified within FNR_nucleotide-bd sharing conserved structural features. The designed protein sequence is ", "reference": "MTKIAEKSKQEYGDLLKEKDHLQDMEQLEMTIVSIQTPYPSIVRIQGKINTLQPELWQAPNLAIRLIVSNPPEGQPISRVYTVRSFNPINAQIEIDFVKHEDLSPAMEWLNSAQVGTKIGLIGPRPHFIPNFTAKKHVVMFADDTAVPALYSILKQWELGISADIFIESFEKDIASQLPELEHVKIHSFHKEHHTSQKGLLLKAAFALEHYENITIWAACERNEARALRQFFLEDQQLNKNDVRIAGYWRDGVSSSELDKLRAQHYQEHIQQGKTLNEYDDLDLAN" }, { "InterPro": [ { "InterPro-ID": "IPR003347", "InterPro-Name": "JmjC_dom", "InterPro-Type": "DOMAIN", "Beg": 697, "End": 789 }, { "InterPro-ID": "IPR003347", "InterPro-Name": "JmjC_dom", "InterPro-Type": "DOMAIN", "Beg": 583, "End": 806 }, { "InterPro-ID": "IPR045109", "InterPro-Name": "JHDM2-like", "InterPro-Type": "FAMILY", "Beg": 71, "End": 838 }, { "InterPro-ID": "IPR003347", "InterPro-Name": "JmjC_dom", "InterPro-Type": "DOMAIN", "Beg": 601, "End": 806 } ], "response#1": "MSQKELAALVATRTSRKRTISSTSFSISTRTDPKSIIEIHIFNDSLPIKRACCEVENPTLKAEQRVQQEEESLGQVPPLTEEEQQRHDEFRNSGSIFLQDLPCFKLQQAQPIAGSSPIPKCRECRRRNLATTEGEPSSVSDVYCRFYEFRRLQFNENGELCVVGFPNPYSEPSPEDIAIWQPDKNTPPTSGYMDIQVCRYILLHAGDQFCYIWHQEAEALSLHQNTDGTIAWKKAVKGTREICDVCDTTLFNYHWTCRKCGFGVCLDCVKDRKEGLRLRRAENAAQKGCDEYHWLLCSDPSGPQEHVLTELMLTQIIAGDALNVLGRLLHEVRTLWQVPQVCGCLLSKQAIEDAQSKEVIQDMIKESQLKQHTSYSSLASEQKVHQQQRLDQLHATKLEFARELGVDYVPGRVWTKETLGKDPITTAFDNLKHINFLRKGLAGLRRFLPPRTMTFAYSTQLAPGVPHEFLCDGRLLRLTDAMHPDNRVLFQEVWKCGQPVMISEVARSLNLDLWHPQAFCRDFGDKPNDLINCLNGNLVPNQPMRHFWEGFQCMTKRLPDAYGKPMLLKLKDWPPGDDFAEILPTRFADLMKGLPMPEYTLRTGNLNIASCLPKMFVPPDLGPKMYNAYGSALHPDKGTTNLHLDISDAVNIMVYVGIPQDGDTRPQMAATQKAIEIGGCDYITRARCQSPDVLPGALWHIFPARDADKIRDLLNRVTLEKGFRLEPDHDPIHDQNWYLDDKLRARLFKEYGVEGHPIVQCLGDAVFIPAGAPHQVQNLHNCIKVAEDFVSPENITHCYHLTHEFRRLSHSHTNHEDKLQIKNIIYHAIKDCCTILTRAVDERLNAELTKLNAD", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more JmjC_dom, JmjC_dom, JmjC_dom that are essential for its biological function; 2. The protein should belong to JHDM2-like that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MSQKELAALVATRTSRKRTISSTSFSISTRTDPKSIIEIHIFNDSLPIKRACCEVENPTLKAEQRVQQEEESLGQVPPLTEEEQQRHDEFRNSGSIFLQDLPCFKLQQAQPIAGSSPIPKCRECRRRNLATTEGEPSSVSDVYCRFYEFRRLQFNENGELCVVGFPNPYSEPSPEDIAIWQPDKNTPPTSGYMDIQVCRYILLHAGDQFCYIWHQEAEALSLHQNTDGTIAWKKAVKGTREICDVCDTTLFNYHWTCRKCGFGVCLDCVKDRKEGLRLRRAENAAQKGCDEYHWLLCSDPSGPQEHVLTELMLTQIIAGDALNVLGRLLHEVRTLWQVPQVCGCLLSKQAIEDAQSKEVIQDMIKESQLKQHTSYSSLASEQKVHQQQRLDQLHATKLEFARELGVDYVPGRVWTKETLGKDPITTAFDNLKHINFLRKGLAGLRRFLPPRTMTFAYSTQLAPGVPHEFLCDGRLLRLTDAMHPDNRVLFQEVWKCGQPVMISEVARSLNLDLWHPQAFCRDFGDKPNDLINCLNGNLVPNQPMRHFWEGFQCMTKRLPDAYGKPMLLKLKDWPPGDDFAEILPTRFADLMKGLPMPEYTLRTGNLNIASCLPKMFVPPDLGPKMYNAYGSALHPDKGTTNLHLDISDAVNIMVYVGIPQDGDTRPQMAATQKAIEIGGCDYITRARCQSPDVLPGALWHIFPARDADKIRDLLNRVTLEKGFRLEPDHDPIHDQNWYLDDKLRARLFKEYGVEGHPIVQCLGDAVFIPAGAPHQVQNLHNCIKVAEDFVSPENITHCYHLTHEFRRLSHSHTNHEDKLQIKNIIYHAIKDCCTILTRAVDERLNAELTKLNAD" }, { "InterPro": [ { "InterPro-ID": "IPR002259", "InterPro-Name": "Eqnu_transpt", "InterPro-Type": "FAMILY", "Beg": 149, "End": 495 }, { "InterPro-ID": "IPR002259", "InterPro-Name": "Eqnu_transpt", "InterPro-Type": "FAMILY", "Beg": 28, "End": 495 }, { "InterPro-ID": "IPR036259", "InterPro-Name": "MFS_trans_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 87, "End": 487 } ], "response#1": "MTGQSAAVEGSNSALPWYRMGFHTLAEFNTYVTFVLLGMSIMMVTSAVTSAPDFVTKYFIYATGDPDAVAETPLFWNNANTFYNAGTYAMQVVTEIASLTPFMRSIPLGIRLFLGLGIPFVELVVIIAVPAATIPTQNGAIAVIMVVAMMGGLSKALCDSCTNALVGPFPTKFMNGAQWGLTVIALFMSIIQIILQVSMGSTFQDVLTISRIYFGIGIGIQVMAIAALVLLRYNPFAQKYIAEFRAAALRRRGHVEPEESQDSKEPATGDVAEAPKAGEKEVTLDAMEEADEVRAVPSDAFVAKSGAVLQATGDADRMVDLDQTKNITSTEQMLRASVWSVFKRIYPMLLCAFTIFFTTLLVFPGVFFLVPARSGWYMTIIVTLFNAGDFVARVLLMIRVLRPSPKLVIVGTFGRLAVIPLIVLCVRGFIPGVALPYVLIFLFGLTNGYFGTMSCIHCPRTPTLHYAGERSVAAMLAGISLMLGLCFGSNMSLAITLTY", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Eqnu_transpt, Eqnu_transpt that shares evolutionary origin and functional similarity; 2. The protein should be classified within MFS_trans_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MTGQSAAVEGSNSALPWYRMGFHTLAEFNTYVTFVLLGMSIMMVTSAVTSAPDFVTKYFIYATGDPDAVAETPLFWNNANTFYNAGTYAMQVVTEIASLTPFMRSIPLGIRLFLGLGIPFVELVVIIAVPAATIPTQNGAIAVIMVVAMMGGLSKALCDSCTNALVGPFPTKFMNGAQWGLTVIALFMSIIQIILQVSMGSTFQDVLTISRIYFGIGIGIQVMAIAALVLLRYNPFAQKYIAEFRAAALRRRGHVEPEESQDSKEPATGDVAEAPKAGEKEVTLDAMEEADEVRAVPSDAFVAKSGAVLQATGDADRMVDLDQTKNITSTEQMLRASVWSVFKRIYPMLLCAFTIFFTTLLVFPGVFFLVPARSGWYMTIIVTLFNAGDFVARVLLMIRVLRPSPKLVIVGTFGRLAVIPLIVLCVRGFIPGVALPYVLIFLFGLTNGYFGTMSCIHCPRTPTLHYAGERSVAAMLAGISLMLGLCFGSNMSLAITLTY" }, { "InterPro": [ { "InterPro-ID": "IPR036396", "InterPro-Name": "Cyt_P450_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 100, "End": 526 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 388, "End": 512 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 155, "End": 370 }, { "InterPro-ID": "IPR036396", "InterPro-Name": "Cyt_P450_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 144, "End": 522 }, { "InterPro-ID": "IPR002403", "InterPro-Name": "Cyt_P450_E_grp-IV", "InterPro-Type": "FAMILY", "Beg": 352, "End": 368 }, { "InterPro-ID": "IPR002403", "InterPro-Name": "Cyt_P450_E_grp-IV", "InterPro-Type": "FAMILY", "Beg": 469, "End": 487 }, { "InterPro-ID": "IPR002403", "InterPro-Name": "Cyt_P450_E_grp-IV", "InterPro-Type": "FAMILY", "Beg": 420, "End": 438 }, { "InterPro-ID": "IPR002403", "InterPro-Name": "Cyt_P450_E_grp-IV", "InterPro-Type": "FAMILY", "Beg": 453, "End": 469 }, { "InterPro-ID": "IPR017972", "InterPro-Name": "Cyt_P450_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 462, "End": 471 } ], "response#1": "MDSAFVLPHPASMGASCILGLLLLTILRALLIPKKALPLAINHHRWDIFNRRAIQDFTANPQDLIKAGLKKVIDPQIAPRFAKGTFLVLPERYSEEVKNDERFSAYEALSRSSPQIILLELPGFESVFEGLMHNDVVLPGVAAMNRQLASLTSPMSEEVSHYLQTNWTDDPDWHTQSVSASMSGLIGQAAARIIVGPELCRNKEYHAITLSYTMSRGRALAAIHAWPRALHPLIHWFLPSCRNVRTQIRRAEKLITPILERTRRHRARGDPPQAFSTLAWSDEYARAQGRSYNATLAQMRFTSSSIHNTSDLLGKVMLRICQRPDLIEPLRREIVAAFDGGSGAQHHSLGKLKLMESVMKETQRLEPAAERVSYPPPLTPERLTGYSIVNMFRVAKETVTLSDGTTIPKGTIFGFSYQNRFDPSMYPDPETFDPYRFMRMRQDPVQASLASFTKARSTHLSFGLGRHACPGRFMANDMIKLALSHILLKYDFKLVGEELPKLEMHGFVYAREPTAQILVRRRQEEVVL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Cyt_P450, Cyt_P450, Cyt_P450_E_grp-IV, Cyt_P450_E_grp-IV, Cyt_P450_E_grp-IV, Cyt_P450_E_grp-IV that shares evolutionary origin and functional similarity; 2. The protein should be classified within Cyt_P450_sf, Cyt_P450_sf sharing conserved structural features; 3. The protein should contain Cyt_P450_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MDSAFVLPHPASMGASCILGLLLLTILRALLIPKKALPLAINHHRWDIFNRRAIQDFTANPQDLIKAGLKKVIDPQIAPRFAKGTFLVLPERYSEEVKNDERFSAYEALSRSSPQIILLELPGFESVFEGLMHNDVVLPGVAAMNRQLASLTSPMSEEVSHYLQTNWTDDPDWHTQSVSASMSGLIGQAAARIIVGPELCRNKEYHAITLSYTMSRGRALAAIHAWPRALHPLIHWFLPSCRNVRTQIRRAEKLITPILERTRRHRARGDPPQAFSTLAWSDEYARAQGRSYNATLAQMRFTSSSIHNTSDLLGKVMLRICQRPDLIEPLRREIVAAFDGGSGAQHHSLGKLKLMESVMKETQRLEPAAERVSYPPPLTPERLTGYSIVNMFRVAKETVTLSDGTTIPKGTIFGFSYQNRFDPSMYPDPETFDPYRFMRMRQDPVQASLASFTKARSTHLSFGLGRHACPGRFMANDMIKLALSHILLKYDFKLVGEELPKLEMHGFVYAREPTAQILVRRRQEEVVL" }, { "InterPro": [ { "InterPro-ID": "IPR003347", "InterPro-Name": "JmjC_dom", "InterPro-Type": "DOMAIN", "Beg": 85, "End": 2198 }, { "InterPro-ID": "IPR003347", "InterPro-Name": "JmjC_dom", "InterPro-Type": "DOMAIN", "Beg": 2033, "End": 2198 }, { "InterPro-ID": "IPR003349", "InterPro-Name": "JmjN", "InterPro-Type": "DOMAIN", "Beg": 1740, "End": 1781 }, { "InterPro-ID": "IPR001606", "InterPro-Name": "ARID_dom", "InterPro-Type": "DOMAIN", "Beg": 1806, "End": 1898 }, { "InterPro-ID": "IPR001606", "InterPro-Name": "ARID_dom", "InterPro-Type": "DOMAIN", "Beg": 1805, "End": 1897 }, { "InterPro-ID": "IPR001606", "InterPro-Name": "ARID_dom", "InterPro-Type": "DOMAIN", "Beg": 1812, "End": 1893 }, { "InterPro-ID": "IPR036431", "InterPro-Name": "ARID_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1789, "End": 1904 }, { "InterPro-ID": "IPR003349", "InterPro-Name": "JmjN", "InterPro-Type": "DOMAIN", "Beg": 1741, "End": 1782 }, { "InterPro-ID": "IPR003349", "InterPro-Name": "JmjN", "InterPro-Type": "DOMAIN", "Beg": 1742, "End": 1775 }, { "InterPro-ID": "IPR004198", "InterPro-Name": "Znf_C5HC2", "InterPro-Type": "DOMAIN", "Beg": 2281, "End": 2334 }, { "InterPro-ID": "IPR003347", "InterPro-Name": "JmjC_dom", "InterPro-Type": "DOMAIN", "Beg": 2066, "End": 2181 }, { "InterPro-ID": "IPR036431", "InterPro-Name": "ARID_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1800, "End": 1916 } ], "response#1": "MVVSKDNNKRRRKETETPPPPPPVPPAGSSLAPPSAVAAIESSPEMPKRTKVQAQRKFAQGQSAPSSSSSIAYSAAAAAAGSGSGPSTSGADSNQPPIEILPNKCPKPQDFLTFLCFRGTRALPAHLDFLNQGKSKDSEASSTGANNNNNARKPNNSRASLAGNKKKRGRPAKGATKKVDVVAPIPDPTEKPSTAEKPASDKNNLIAAEAPKIPSRNPTPVLPGAVRKRAEVVTDGNRRGARGRGAGISHDKTTPAALSKDNKRRSNRASTKESKPVIDDDNSEDLDEQEADDDEDEFFSAHDATSRNGEEVKADSPVKAEPTKRGRPSAAKKAVEPAPEGQTVLKDKAPVKRVRQRESPIFIPSPESSGRMTRQRAFFEPVKVPPHKEEPGAHDPPKDEPKKQPETPPSKTEKEQEPTKQIKEAKEKTNSSIYAKEAKQQLENGDSLHGAVAKGKKSLNVFDFSSDDEQPLAKSIKLKKGAKGASPKKGGAAPIAPAARNRKAAAKKLDKEKEIEKEKQREKEEEIERDKAKEKKDKEKEKEKEKHPVPESKVEEPPSGGKRGKAGKKKAEDAPADEEDLAPPSSKKVATNARGSRKSAKSKASEDSAELEPQRSQRPSRKTKEAAAIYMGIIGHKLQLADDEEDDLSMSSFPDIPNVKEMEKMENEIKRNAAGKLNVPEASTVLSAGKSTRKPSPRPKDSPVTAPVEATRNESPSPPEAEEEKPPPPARRGRPPKQNKVNAGPAHKPRIEGMLVKKGSLAKMSEQQAKPKAKSEHSKVDSDEEEDFLINEELNETKRKLEKSFSDSDDEPLAIKVPAVAVKEKELLPPKMASPPPKLVPVPSPISVPTPAVSVAPSLAVPSILPTSTGTTQLTMLPLTAKATSSLGSMPMFPSIQASYSPLKTMEKKPPVPTSKILNVPATYALPGSASGAVSFQKTSSYLPQASPHYHSGYVRPPPTPTHQFGGGAPSGSKTPSQGSSPLKYQTPPTTYPPPIEAYQCPKINPNFLTPKYERSPLPRSSTSSFPSPSPVKFQPTSGTTATTVGTPSSATKSPLAPPPPSPPVSQVVIQTSSLNLSMSIAATVNAAPMPVASTSAAAAHQTTVATTVTATSTPPPAHSNSAATGGGAGANSDPLKDEIGSILAQATLMPSKEESGKIFGIASVSLAQSSGPDNTKCTLGKCGSIHKPVLGPVVPTEGYFGDQLSSKERRKAKVNMTHEQIQKWLIECSSNPDEIQDDLDDDFDDSLRPQQSTTPPPTRDDKELSASFSSSSKNTRGDLGKSESAWSAKGPSLKATPVLVTPPNRKELHEQADSKDCDALDYDKSSTPVNLTQKITSNESLAVEKKVNDRKGKESAKAAASKAATQPRSTAATPPTPISSTPTPASLTPSKSSPTPPPAVKQKAEKGKRNATAGGGATALASPPAAPTPANPKRTPVYNQKNAKAQQQQAETKPASNPPSGAGTKRESVYAFGKDDESGSKSGNRRRTDPSPVPAPALVPNALSERSPTKKRAAAAAAATAVQLTLSPTENCKIEGKPSKAPTGRGAKKQQQQAPAPPAPPVEASGDSDAEGATFYIPLQGAGVGGSGDGGIQGVAVKLGREGPDGPNQKVVMQATLVTKAQMDTNSKPLPESLNTNELVKTLLHAASNDAASTTTSLKSLPKASTSAAAGAAAAPGASSLVRVNSNSSLFSGSAKSRTAAQTSSTAAAVAKKYKDDTPIKMANNTAFPRHDDPTQMVEAPIFRPTEKEFADPIEFIERITPIAARFGICKIIPPASFKPECRISDEMRFTAYNQYVHKMLHRWGPSAKELSAIKKYLATQSIVMNHPPWIGGMEVDLPRLYHTVQELGGLKEVIEKKKWARVAEEMCIPKLAQDRVTKLDDIYCKYLLPYDTLSPAERQKLFDEVEADWAKREARARRNADRFVNTESVSNEEDDLSSDEDEESEEEIDGVSMECIVKGRSMPLSQFYRIARNTMALWFKSTDPTVNEVEAEFWRHVAVRDSHVCVHSGSIDSSGWGYGFPSPGPKGKGSNYARHPWNLKVLTNNSGSVLRSLGPVMGVTVPTLHVGMLFSACCWYRDPHGLSWIEYLHTGASKLWYGIPDDQSANFRAALTSLIPTHCQNKTIWLPCDTVMVPPHMLTDRGVSLCRIEQKPGEFIVVFPRAYTSSLATGYVVSESVYFATMSWLDLAKDDFRDIHESCEPAMFSLEQLLFALGYDQRVNSEALHQMLPMLNDVCEKESAAREQLRAAGVTSTEKVQAEKGQKAKKQQQPPYKSIESECDLCRANLYISMVRTEDGNIYCLQHALKNLNNGNIQAKQCKLIYAYNVDDIQQLIRQLQEKINHKAAVKKK", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more JmjC_dom, JmjC_dom, JmjN, ARID_dom, ARID_dom, ARID_dom, JmjN, JmjN, Znf_C5HC2, JmjC_dom that are essential for its biological function; 2. The protein should be classified within ARID_dom_sf, ARID_dom_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MVVSKDNNKRRRKETETPPPPPPVPPAGSSLAPPSAVAAIESSPEMPKRTKVQAQRKFAQGQSAPSSSSSIAYSAAAAAAGSGSGPSTSGADSNQPPIEILPNKCPKPQDFLTFLCFRGTRALPAHLDFLNQGKSKDSEASSTGANNNNNARKPNNSRASLAGNKKKRGRPAKGATKKVDVVAPIPDPTEKPSTAEKPASDKNNLIAAEAPKIPSRNPTPVLPGAVRKRAEVVTDGNRRGARGRGAGISHDKTTPAALSKDNKRRSNRASTKESKPVIDDDNSEDLDEQEADDDEDEFFSAHDATSRNGEEVKADSPVKAEPTKRGRPSAAKKAVEPAPEGQTVLKDKAPVKRVRQRESPIFIPSPESSGRMTRQRAFFEPVKVPPHKEEPGAHDPPKDEPKKQPETPPSKTEKEQEPTKQIKEAKEKTNSSIYAKEAKQQLENGDSLHGAVAKGKKSLNVFDFSSDDEQPLAKSIKLKKGAKGASPKKGGAAPIAPAARNRKAAAKKLDKEKEIEKEKQREKEEEIERDKAKEKKDKEKEKEKEKHPVPESKVEEPPSGGKRGKAGKKKAEDAPADEEDLAPPSSKKVATNARGSRKSAKSKASEDSAELEPQRSQRPSRKTKEAAAIYMGIIGHKLQLADDEEDDLSMSSFPDIPNVKEMEKMENEIKRNAAGKLNVPEASTVLSAGKSTRKPSPRPKDSPVTAPVEATRNESPSPPEAEEEKPPPPARRGRPPKQNKVNAGPAHKPRIEGMLVKKGSLAKMSEQQAKPKAKSEHSKVDSDEEEDFLINEELNETKRKLEKSFSDSDDEPLAIKVPAVAVKEKELLPPKMASPPPKLVPVPSPISVPTPAVSVAPSLAVPSILPTSTGTTQLTMLPLTAKATSSLGSMPMFPSIQASYSPLKTMEKKPPVPTSKILNVPATYALPGSASGAVSFQKTSSYLPQASPHYHSGYVRPPPTPTHQFGGGAPSGSKTPSQGSSPLKYQTPPTTYPPPIEAYQCPKINPNFLTPKYERSPLPRSSTSSFPSPSPVKFQPTSGTTATTVGTPSSATKSPLAPPPPSPPVSQVVIQTSSLNLSMSIAATVNAAPMPVASTSAAAAHQTTVATTVTATSTPPPAHSNSAATGGGAGANSDPLKDEIGSILAQATLMPSKEESGKIFGIASVSLAQSSGPDNTKCTLGKCGSIHKPVLGPVVPTEGYFGDQLSSKERRKAKVNMTHEQIQKWLIECSSNPDEIQDDLDDDFDDSLRPQQSTTPPPTRDDKELSASFSSSSKNTRGDLGKSESAWSAKGPSLKATPVLVTPPNRKELHEQADSKDCDALDYDKSSTPVNLTQKITSNESLAVEKKVNDRKGKESAKAAASKAATQPRSTAATPPTPISSTPTPASLTPSKSSPTPPPAVKQKAEKGKRNATAGGGATALASPPAAPTPANPKRTPVYNQKNAKAQQQQAETKPASNPPSGAGTKRESVYAFGKDDESGSKSGNRRRTDPSPVPAPALVPNALSERSPTKKRAAAAAAATAVQLTLSPTENCKIEGKPSKAPTGRGAKKQQQQAPAPPAPPVEASGDSDAEGATFYIPLQGAGVGGSGDGGIQGVAVKLGREGPDGPNQKVVMQATLVTKAQMDTNSKPLPESLNTNELVKTLLHAASNDAASTTTSLKSLPKASTSAAAGAAAAPGASSLVRVNSNSSLFSGSAKSRTAAQTSSTAAAVAKKYKDDTPIKMANNTAFPRHDDPTQMVEAPIFRPTEKEFADPIEFIERITPIAARFGICKIIPPASFKPECRISDEMRFTAYNQYVHKMLHRWGPSAKELSAIKKYLATQSIVMNHPPWIGGMEVDLPRLYHTVQELGGLKEVIEKKKWARVAEEMCIPKLAQDRVTKLDDIYCKYLLPYDTLSPAERQKLFDEVEADWAKREARARRNADRFVNTESVSNEEDDLSSDEDEESEEEIDGVSMECIVKGRSMPLSQFYRIARNTMALWFKSTDPTVNEVEAEFWRHVAVRDSHVCVHSGSIDSSGWGYGFPSPGPKGKGSNYARHPWNLKVLTNNSGSVLRSLGPVMGVTVPTLHVGMLFSACCWYRDPHGLSWIEYLHTGASKLWYGIPDDQSANFRAALTSLIPTHCQNKTIWLPCDTVMVPPHMLTDRGVSLCRIEQKPGEFIVVFPRAYTSSLATGYVVSESVYFATMSWLDLAKDDFRDIHESCEPAMFSLEQLLFALGYDQRVNSEALHQMLPMLNDVCEKESAAREQLRAAGVTSTEKVQAEKGQKAKKQQQPPYKSIESECDLCRANLYISMVRTEDGNIYCLQHALKNLNNGNIQAKQCKLIYAYNVDDIQQLIRQLQEKINHKAAVKKK" }, { "InterPro": [ { "InterPro-ID": "IPR041667", "InterPro-Name": "Cupin_8", "InterPro-Type": "DOMAIN", "Beg": 35, "End": 298 }, { "InterPro-ID": "IPR003347", "InterPro-Name": "JmjC_dom", "InterPro-Type": "DOMAIN", "Beg": 124, "End": 310 }, { "InterPro-ID": "IPR014710", "InterPro-Name": "RmlC-like_jellyroll", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1, "End": 315 }, { "InterPro-ID": "IPR003347", "InterPro-Name": "JmjC_dom", "InterPro-Type": "DOMAIN", "Beg": 124, "End": 308 } ], "response#1": "MSEVERALDVLLQEAEELCIGSSVVELDRIPTALEFCREFYSKNQPVVIRKALNWPAIGKWTPKYLIEALGDRSVDVAITPNGYADGLATQNGQEYFVLPLETKMKLSEVVRRLDDPTGAVHYIQKQNSNLSVDLPELAADLRVSDLDFAQQSFNKPPDAVNFWLGDERAVTSMHKDPYENVYCVISGHKDFVLIPPHQLSCVPRGIYPTGVYKTSDSGQFYIEPLRDEEGSDQFTEWVSVDPLSPDLAKYPEYARAKPLKVRVHAGDILYLPNYWFHHVSQSHKCIAVNFWYDLDYDSRYCYYRMLEQMTSARSG", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Cupin_8, JmjC_dom, JmjC_dom that are essential for its biological function; 2. The protein should be classified within RmlC-like_jellyroll sharing conserved structural features. The designed protein sequence is ", "reference": "MSEVERALDVLLQEAEELCIGSSVVELDRIPTALEFCREFYSKNQPVVIRKALNWPAIGKWTPKYLIEALGDRSVDVAITPNGYADGLATQNGQEYFVLPLETKMKLSEVVRRLDDPTGAVHYIQKQNSNLSVDLPELAADLRVSDLDFAQQSFNKPPDAVNFWLGDERAVTSMHKDPYENVYCVISGHKDFVLIPPHQLSCVPRGIYPTGVYKTSDSGQFYIEPLRDEEGSDQFTEWVSVDPLSPDLAKYPEYARAKPLKVRVHAGDILYLPNYWFHHVSQSHKCIAVNFWYDLDYDSRYCYYRMLEQMTSARSG" }, { "InterPro": [ { "InterPro-ID": "IPR003347", "InterPro-Name": "JmjC_dom", "InterPro-Type": "DOMAIN", "Beg": 255, "End": 401 }, { "InterPro-ID": "IPR041667", "InterPro-Name": "Cupin_8", "InterPro-Type": "DOMAIN", "Beg": 173, "End": 401 } ], "response#1": "MDSEFLELTQLLPRWVDLENVVRGEVEARYILKRAADHLANLRSGGDSGAEETGYLVGALVDRNWERIHTGHFSQVPLVTRKIYAIACCFKIFFLLLESTSPAQKDACSEILDEAQLLGCMEDWSELKVALMDYLDKDGAVALNSAPLPTLEPLTRVTSNCDIPQLDAPSLEEFQTKCFEAGQPTLLLNTIQHWPALHKWLDLNYLLQVAGNRTVPIEIGSNYASDEWSQQLVKIRDFLSRQFGKEPSKAGQNIEYLAQHELFAQIPALKEDISIPDYCTISNEDTPGAVDIKAWLGPAGTVSPMHYDPKHNLLCQVFGSKRIILAAPADTDNLYPHDSEFLANTARIDAAQLDPETYPLVAKVKFYQLLLQPGDCLYMPPKWWHYVRSEAPSFSVSFWWE", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more JmjC_dom, Cupin_8 that are essential for its biological function. The designed protein sequence is ", "reference": "MDSEFLELTQLLPRWVDLENVVRGEVEARYILKRAADHLANLRSGGDSGAEETGYLVGALVDRNWERIHTGHFSQVPLVTRKIYAIACCFKIFFLLLESTSPAQKDACSEILDEAQLLGCMEDWSELKVALMDYLDKDGAVALNSAPLPTLEPLTRVTSNCDIPQLDAPSLEEFQTKCFEAGQPTLLLNTIQHWPALHKWLDLNYLLQVAGNRTVPIEIGSNYASDEWSQQLVKIRDFLSRQFGKEPSKAGQNIEYLAQHELFAQIPALKEDISIPDYCTISNEDTPGAVDIKAWLGPAGTVSPMHYDPKHNLLCQVFGSKRIILAAPADTDNLYPHDSEFLANTARIDAAQLDPETYPLVAKVKFYQLLLQPGDCLYMPPKWWHYVRSEAPSFSVSFWWE" }, { "InterPro": [ { "InterPro-ID": "IPR016285", "InterPro-Name": "Hemagglutn-neuramid", "InterPro-Type": "FAMILY", "Beg": 166, "End": 578 }, { "InterPro-ID": "IPR000665", "InterPro-Name": "Hemagglutn/HN", "InterPro-Type": "FAMILY", "Beg": 37, "End": 581 }, { "InterPro-ID": "IPR016285", "InterPro-Name": "Hemagglutn-neuramid", "InterPro-Type": "FAMILY", "Beg": 1, "End": 582 }, { "InterPro-ID": "IPR036278", "InterPro-Name": "Sialidase_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 133, "End": 581 } ], "response#1": "MEPSKLFTMSDNATFAPGPVVNAADKKTFRTCFRILVLSVQAVTLILVIVTLGELVRMINDQGLSNQLSSIADKIRESATMIASAVGVMNQVIHGVTVSLPLQIEGNQNQLLSTLATIRTGKKQVSNCSTNIPLVNDLRFINGINKFIIEDYATHDFSIGHPLNMPSFIPTATSPNGCTRIPSFSLGKTHWCYTHNVINANCKDHTSSNQYISMGILVQTASGYPMFKTLKIQYLSDGLNRKSCSIATVPDGCAMYCYVSTQLETDDYAGSSPPTQKLTLLFYNDTVTERTISPTGLEGNWATLVPGVGSGIYFENKLIFPAYGGVLPNSTLGVKSAREFFRPVNPYNPCSGPQQDLDQRALRSYFPSYFSNRRVQSAFLVCAWNQILVTNCELVVPSNNQTLMGAEGRVLLINNRLLYYQRSTSWWPYELLYEISFTFTNSGQSSVNMSWIPIYSFTRPGSGNCSGENVCPTACVSGVYLDPWPLTPYSHQSGINRNFYFTGALLNSSTTRVNPTLYVSALNNLKVLAPYGNQGLFASYTTTTCFQDTGDASVYCVYIMELASNIVGEFQILPVLTRLTIT", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Hemagglutn-neuramid, Hemagglutn/HN, Hemagglutn-neuramid that shares evolutionary origin and functional similarity; 2. The protein should be classified within Sialidase_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MEPSKLFTMSDNATFAPGPVVNAADKKTFRTCFRILVLSVQAVTLILVIVTLGELVRMINDQGLSNQLSSIADKIRESATMIASAVGVMNQVIHGVTVSLPLQIEGNQNQLLSTLATIRTGKKQVSNCSTNIPLVNDLRFINGINKFIIEDYATHDFSIGHPLNMPSFIPTATSPNGCTRIPSFSLGKTHWCYTHNVINANCKDHTSSNQYISMGILVQTASGYPMFKTLKIQYLSDGLNRKSCSIATVPDGCAMYCYVSTQLETDDYAGSSPPTQKLTLLFYNDTVTERTISPTGLEGNWATLVPGVGSGIYFENKLIFPAYGGVLPNSTLGVKSAREFFRPVNPYNPCSGPQQDLDQRALRSYFPSYFSNRRVQSAFLVCAWNQILVTNCELVVPSNNQTLMGAEGRVLLINNRLLYYQRSTSWWPYELLYEISFTFTNSGQSSVNMSWIPIYSFTRPGSGNCSGENVCPTACVSGVYLDPWPLTPYSHQSGINRNFYFTGALLNSSTTRVNPTLYVSALNNLKVLAPYGNQGLFASYTTTTCFQDTGDASVYCVYIMELASNIVGEFQILPVLTRLTIT" }, { "InterPro": [ { "InterPro-ID": "IPR036396", "InterPro-Name": "Cyt_P450_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 30, "End": 506 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 364, "End": 382 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 300, "End": 317 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 452, "End": 475 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 320, "End": 346 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 442, "End": 452 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 406, "End": 430 }, { "InterPro-ID": "IPR017972", "InterPro-Name": "Cyt_P450_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 445, "End": 454 }, { "InterPro-ID": "IPR036396", "InterPro-Name": "Cyt_P450_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 29, "End": 497 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 64, "End": 478 }, { "InterPro-ID": "IPR050121", "InterPro-Name": "Cytochrome_P450_monoxygenase", "InterPro-Type": "FAMILY", "Beg": 8, "End": 476 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 311, "End": 328 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 452, "End": 463 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 443, "End": 452 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 365, "End": 376 } ], "response#1": "MLFQDLSFPAAVGAAFGAFAIYVVARCIYDLFFHPLRNFPGPKRAAIWSFYEFYYDVIKDGTYLWEIEKMHQRYGPIVRINSRSLHIHDPEYFSTIYAGSGRKVNKELSAVSGYTFPHSTISTLEHDLHRKRRAIVNPYFSKRAIADVEPVIHERLDTLISRLAEAKGNTVDLTCAFSAFTADVVTYHFYGSHANYIGSKDFKYGLKDALTVLLNLYNLTRFLPVPPTTIKNLPLPILGLINPNFPLVVSAREANKKMVLNYLDKPDEEKKAMKDARSKSVIVSALADSNVPDEEKTLDRLLDEGETIIFAGIDTTARTLAVALFHLLNNQDVLMKLRKELQTIAKSDGQQWTTTELEAVPYMRGVVQEAIRLAYGLVVRIPRISPHEALQYNGFVIPPGTPVSQSTYLVNNDASVFPNPQVFDPERWVKAAQDGTNLDKYMVSFSKGSRACLGINLAYAKLYLGIARVATSLDMELFETTRADIGVYHTRGFAFPKEGDGSVKARVRGLCK", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Cyt_P450_E_grp-I, Cyt_P450_E_grp-I, Cyt_P450_E_grp-I, Cyt_P450_E_grp-I, Cyt_P450_E_grp-I, Cyt_P450_E_grp-I, Cyt_P450, Cytochrome_P450_monoxygenase, Cyt_P450, Cyt_P450, Cyt_P450, Cyt_P450 that shares evolutionary origin and functional similarity; 2. The protein should be classified within Cyt_P450_sf, Cyt_P450_sf sharing conserved structural features; 3. The protein should contain Cyt_P450_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MLFQDLSFPAAVGAAFGAFAIYVVARCIYDLFFHPLRNFPGPKRAAIWSFYEFYYDVIKDGTYLWEIEKMHQRYGPIVRINSRSLHIHDPEYFSTIYAGSGRKVNKELSAVSGYTFPHSTISTLEHDLHRKRRAIVNPYFSKRAIADVEPVIHERLDTLISRLAEAKGNTVDLTCAFSAFTADVVTYHFYGSHANYIGSKDFKYGLKDALTVLLNLYNLTRFLPVPPTTIKNLPLPILGLINPNFPLVVSAREANKKMVLNYLDKPDEEKKAMKDARSKSVIVSALADSNVPDEEKTLDRLLDEGETIIFAGIDTTARTLAVALFHLLNNQDVLMKLRKELQTIAKSDGQQWTTTELEAVPYMRGVVQEAIRLAYGLVVRIPRISPHEALQYNGFVIPPGTPVSQSTYLVNNDASVFPNPQVFDPERWVKAAQDGTNLDKYMVSFSKGSRACLGINLAYAKLYLGIARVATSLDMELFETTRADIGVYHTRGFAFPKEGDGSVKARVRGLCK" }, { "InterPro": [ { "InterPro-ID": "IPR036396", "InterPro-Name": "Cyt_P450_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 152, "End": 535 }, { "InterPro-ID": "IPR002403", "InterPro-Name": "Cyt_P450_E_grp-IV", "InterPro-Type": "FAMILY", "Beg": 374, "End": 390 }, { "InterPro-ID": "IPR002403", "InterPro-Name": "Cyt_P450_E_grp-IV", "InterPro-Type": "FAMILY", "Beg": 463, "End": 479 }, { "InterPro-ID": "IPR002403", "InterPro-Name": "Cyt_P450_E_grp-IV", "InterPro-Type": "FAMILY", "Beg": 426, "End": 444 }, { "InterPro-ID": "IPR002403", "InterPro-Name": "Cyt_P450_E_grp-IV", "InterPro-Type": "FAMILY", "Beg": 479, "End": 497 }, { "InterPro-ID": "IPR036396", "InterPro-Name": "Cyt_P450_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 54, "End": 536 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 154, "End": 529 }, { "InterPro-ID": "IPR017972", "InterPro-Name": "Cyt_P450_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 472, "End": 481 } ], "response#1": "MGASTFSQSFAEKYEAWASVMLPALVGFAFLIYQAFFAIKYPANLPLAGEPDGKRTFSWRTRWRYYTDCEALYKETYENYTKRGKTVLLPGLGFRHDIILPQSSMRDIMAHPEKELSHADAVLELVQLKYSLGHEKYKADPWPCMLVKSDINSKLEAVCDGMNEELKYAFDKYIGCDTESWKEIDLLETIRMVIIAAASRFTVGFPLCRNEAYLRACWKVNDGIMMNGGLTGATPRLLRPIFGPLITMNLRRNIEKIKKQVEPVYCQRVQALSQQNSAEKPDSEEPKDLFQQMLRYAQKERPRELHDLPSMSRRLAFANFAAVHQTTILVTNMILNIVSSDSQYNTISVLRDEVNDIIGPDSNTKWTKYKVAQMIKSDSVARETMRLHSNTNRGVFRKVLVEGIKTEDGIELPKGAYVSFLGRPLQCNPETFEDPFKYDPFRFSRVREKAPRDAKATSNLSFVSTSPEHLPFGHGGHSCPGRFLVDFEVKMIVAYLLMNYDVEFPAEYNGQRPASRWMAEALMPPSGARIRIKRRS", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Cyt_P450_E_grp-IV, Cyt_P450_E_grp-IV, Cyt_P450_E_grp-IV, Cyt_P450_E_grp-IV, Cyt_P450 that shares evolutionary origin and functional similarity; 2. The protein should be classified within Cyt_P450_sf, Cyt_P450_sf sharing conserved structural features; 3. The protein should contain Cyt_P450_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MGASTFSQSFAEKYEAWASVMLPALVGFAFLIYQAFFAIKYPANLPLAGEPDGKRTFSWRTRWRYYTDCEALYKETYENYTKRGKTVLLPGLGFRHDIILPQSSMRDIMAHPEKELSHADAVLELVQLKYSLGHEKYKADPWPCMLVKSDINSKLEAVCDGMNEELKYAFDKYIGCDTESWKEIDLLETIRMVIIAAASRFTVGFPLCRNEAYLRACWKVNDGIMMNGGLTGATPRLLRPIFGPLITMNLRRNIEKIKKQVEPVYCQRVQALSQQNSAEKPDSEEPKDLFQQMLRYAQKERPRELHDLPSMSRRLAFANFAAVHQTTILVTNMILNIVSSDSQYNTISVLRDEVNDIIGPDSNTKWTKYKVAQMIKSDSVARETMRLHSNTNRGVFRKVLVEGIKTEDGIELPKGAYVSFLGRPLQCNPETFEDPFKYDPFRFSRVREKAPRDAKATSNLSFVSTSPEHLPFGHGGHSCPGRFLVDFEVKMIVAYLLMNYDVEFPAEYNGQRPASRWMAEALMPPSGARIRIKRRS" }, { "InterPro": [ { "InterPro-ID": "IPR001106", "InterPro-Name": "Aromatic_Lyase", "InterPro-Type": "FAMILY", "Beg": 36, "End": 511 }, { "InterPro-ID": "IPR024083", "InterPro-Name": "Fumarase/histidase_N", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 4, "End": 248 }, { "InterPro-ID": "IPR005922", "InterPro-Name": "Phe_NH3-lyase", "InterPro-Type": "FAMILY", "Beg": 27, "End": 701 }, { "InterPro-ID": "IPR022313", "InterPro-Name": "Phe/His_NH3-lyase_AS", "InterPro-Type": "ACTIVE_SITE", "Beg": 186, "End": 201 }, { "InterPro-ID": "IPR008948", "InterPro-Name": "L-Aspartase-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 23, "End": 704 }, { "InterPro-ID": "IPR001106", "InterPro-Name": "Aromatic_Lyase", "InterPro-Type": "FAMILY", "Beg": 38, "End": 512 }, { "InterPro-ID": "IPR001106", "InterPro-Name": "Aromatic_Lyase", "InterPro-Type": "FAMILY", "Beg": 30, "End": 704 }, { "InterPro-ID": "IPR023144", "InterPro-Name": "Phe_NH3-lyase_shielding_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 514, "End": 634 } ], "response#1": "MLQPSAQGSYSKAVLSTFRSLEDLTCDGSKIILDGQSLNVSSVVAAACHQVPASISKDPQLHARLRESVELLARKLAEGEIVYGVNTGFGGSADTRTDDYSTLQQALVQHQASGVLLPTDRSSSRPSSRYPHGLRSHSMPTAVVKAAMLVRCNSLLRGHSAVRPEVIEHILAFLRSGLIPVVPVRGSISASGDLSPLSYIANALEGNPDIAIQNEATGDVIRADEALQQLGLAPLRFGPKEGLGLLNGTAFSAGAASLVLFEANQLVLLSQVLTAMGTEALAGSTGNYHPFIAGVRPHRGQIEAAGNIFHFLRDSRMATSPGADGASHSSSLAQDRYALRTASQWIGPQIEDMSLASEQVHCELNSTTDNPLLDPGSGHMHHGGNFQATSITSAMEKTMSAMQMLGRMIFSQCTELINPALNNGLPPNLSFDDPSLSFTMKGIDINMSAYMAELSYLNHHVSNHVQSAEMHNQGLNSLALVASRYAAETVEVLSLMASAYLYALCQALDLRACHLEFLRNARSTVDSLTAELCLSFSPLLSESDQRQIQDSTWEQLLHHWNRSSTSDLHDRSRNAASHTMGALVELLPMQLNEATALPTRLAPQQQWLDEVSATLAGSYDATRAKFQSNPTTPFYLCSASRRMYEFVRKGLGVPLHRGIVDHPTYPSVTEEHAGQELIGSQVSKIYMALRGGVFRDVLQDCWYSSDSVRGFAGEELVLASKL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Aromatic_Lyase, Phe_NH3-lyase, Aromatic_Lyase, Aromatic_Lyase that shares evolutionary origin and functional similarity; 2. The protein should be classified within Fumarase/histidase_N, L-Aspartase-like, Phe_NH3-lyase_shielding_dom_sf sharing conserved structural features; 3. The protein must have Phe/His_NH3-lyase_AS that is conserved among related catalytic enzymes. The designed protein sequence is ", "reference": "MLQPSAQGSYSKAVLSTFRSLEDLTCDGSKIILDGQSLNVSSVVAAACHQVPASISKDPQLHARLRESVELLARKLAEGEIVYGVNTGFGGSADTRTDDYSTLQQALVQHQASGVLLPTDRSSSRPSSRYPHGLRSHSMPTAVVKAAMLVRCNSLLRGHSAVRPEVIEHILAFLRSGLIPVVPVRGSISASGDLSPLSYIANALEGNPDIAIQNEATGDVIRADEALQQLGLAPLRFGPKEGLGLLNGTAFSAGAASLVLFEANQLVLLSQVLTAMGTEALAGSTGNYHPFIAGVRPHRGQIEAAGNIFHFLRDSRMATSPGADGASHSSSLAQDRYALRTASQWIGPQIEDMSLASEQVHCELNSTTDNPLLDPGSGHMHHGGNFQATSITSAMEKTMSAMQMLGRMIFSQCTELINPALNNGLPPNLSFDDPSLSFTMKGIDINMSAYMAELSYLNHHVSNHVQSAEMHNQGLNSLALVASRYAAETVEVLSLMASAYLYALCQALDLRACHLEFLRNARSTVDSLTAELCLSFSPLLSESDQRQIQDSTWEQLLHHWNRSSTSDLHDRSRNAASHTMGALVELLPMQLNEATALPTRLAPQQQWLDEVSATLAGSYDATRAKFQSNPTTPFYLCSASRRMYEFVRKGLGVPLHRGIVDHPTYPSVTEEHAGQELIGSQVSKIYMALRGGVFRDVLQDCWYSSDSVRGFAGEELVLASKL" }, { "InterPro": [ { "InterPro-ID": "IPR017996", "InterPro-Name": "Royal_jelly/protein_yellow", "InterPro-Type": "FAMILY", "Beg": 5, "End": 30 }, { "InterPro-ID": "IPR017996", "InterPro-Name": "Royal_jelly/protein_yellow", "InterPro-Type": "FAMILY", "Beg": 152, "End": 176 }, { "InterPro-ID": "IPR017996", "InterPro-Name": "Royal_jelly/protein_yellow", "InterPro-Type": "FAMILY", "Beg": 211, "End": 228 }, { "InterPro-ID": "IPR017996", "InterPro-Name": "Royal_jelly/protein_yellow", "InterPro-Type": "FAMILY", "Beg": 77, "End": 98 }, { "InterPro-ID": "IPR017996", "InterPro-Name": "Royal_jelly/protein_yellow", "InterPro-Type": "FAMILY", "Beg": 53, "End": 75 }, { "InterPro-ID": "IPR017996", "InterPro-Name": "Royal_jelly/protein_yellow", "InterPro-Type": "FAMILY", "Beg": 304, "End": 323 }, { "InterPro-ID": "IPR017996", "InterPro-Name": "Royal_jelly/protein_yellow", "InterPro-Type": "FAMILY", "Beg": 31, "End": 52 }, { "InterPro-ID": "IPR017996", "InterPro-Name": "Royal_jelly/protein_yellow", "InterPro-Type": "FAMILY", "Beg": 326, "End": 348 }, { "InterPro-ID": "IPR017996", "InterPro-Name": "Royal_jelly/protein_yellow", "InterPro-Type": "FAMILY", "Beg": 25, "End": 433 }, { "InterPro-ID": "IPR017996", "InterPro-Name": "Royal_jelly/protein_yellow", "InterPro-Type": "FAMILY", "Beg": 123, "End": 416 }, { "InterPro-ID": "IPR011042", "InterPro-Name": "6-blade_b-propeller_TolB-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 33, "End": 419 } ], "response#1": "MTRWLFMVACLGIACQGAILRENSARNLKNSLKVMHEWKYIDYDFGSEEKRQAAIQSDEYDHTKNYPFDVDQWRDKTFVTVLRYDGVPSSLNVISEKTGNGGRLLQPYPDWSWTKYKDCSGIVSAYSIAIDKFDRLWVLDSGLVNNTQPMCFPKLLVFDLNSSQLIKQVDIPHEIAVNTTTEQGRLKSLAVQAISSVNTLVYIADNKGDGLIVYQNSDDSFHRLTSNTFNYDPRYTKMTVEGESFTVQDGIYGMALSPMTNNLYYSPLASRDLYYVNTKPFIKSEYGENKVQYNGVQDVFNTQTTAKAVSKNGILFFGLVNNTAVGCWNEHQTLQRENTDMVAQNEETLQMIVGMKIKQLLPHIVIIDIDNIINDEYMLVLTNRMQKILNNDLNFNDINFRILIGGVSDLLENTRCTNFNIQNDDSDENNDDSIRITIDASFN", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Royal_jelly/protein_yellow, Royal_jelly/protein_yellow, Royal_jelly/protein_yellow, Royal_jelly/protein_yellow, Royal_jelly/protein_yellow, Royal_jelly/protein_yellow, Royal_jelly/protein_yellow, Royal_jelly/protein_yellow, Royal_jelly/protein_yellow, Royal_jelly/protein_yellow that shares evolutionary origin and functional similarity; 2. The protein should be classified within 6-blade_b-propeller_TolB-like sharing conserved structural features. The designed protein sequence is ", "reference": "MTRWLFMVACLGIACQGAILRENSARNLKNSLKVMHEWKYIDYDFGSEEKRQAAIQSDEYDHTKNYPFDVDQWRDKTFVTVLRYDGVPSSLNVISEKTGNGGRLLQPYPDWSWTKYKDCSGIVSAYSIAIDKFDRLWVLDSGLVNNTQPMCFPKLLVFDLNSSQLIKQVDIPHEIAVNTTTEQGRLKSLAVQAISSVNTLVYIADNKGDGLIVYQNSDDSFHRLTSNTFNYDPRYTKMTVEGESFTVQDGIYGMALSPMTNNLYYSPLASRDLYYVNTKPFIKSEYGENKVQYNGVQDVFNTQTTAKAVSKNGILFFGLVNNTAVGCWNEHQTLQRENTDMVAQNEETLQMIVGMKIKQLLPHIVIIDIDNIINDEYMLVLTNRMQKILNNDLNFNDINFRILIGGVSDLLENTRCTNFNIQNDDSDENNDDSIRITIDASFN" }, { "InterPro": [ { "InterPro-ID": "IPR000719", "InterPro-Name": "Prot_kinase_dom", "InterPro-Type": "DOMAIN", "Beg": 209, "End": 463 }, { "InterPro-ID": "IPR017441", "InterPro-Name": "Protein_kinase_ATP_BS", "InterPro-Type": "BINDING_SITE", "Beg": 214, "End": 237 }, { "InterPro-ID": "IPR008271", "InterPro-Name": "Ser/Thr_kinase_AS", "InterPro-Type": "ACTIVE_SITE", "Beg": 327, "End": 339 }, { "InterPro-ID": "IPR000719", "InterPro-Name": "Prot_kinase_dom", "InterPro-Type": "DOMAIN", "Beg": 208, "End": 463 }, { "InterPro-ID": "IPR011009", "InterPro-Name": "Kinase-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 192, "End": 486 }, { "InterPro-ID": "IPR000961", "InterPro-Name": "AGC-kinase_C", "InterPro-Type": "DOMAIN", "Beg": 464, "End": 519 } ], "response#1": "MLPDTGILSPFTTAVNPDPPQSQTLRVPRPTPVLDRPTTDSTANKRVKLDPTVSKVPWEPSVKPSSSKVEGASGLEQDSFMPTLGSVFKKKKKDKEATRLKDSSGNPDTIIEDSPVTPSTERSLSQSLGSAPSTATTANSHGGLSTVTSATSQTPTSPIATGGQAEKDHPMTTPVNESAGHSRSDSQTLQKAENAVRATKGKYTLQDFNFQRTLGTGSFGRVHLVQSKHNLRFYAVKVLKKAQVVKMKQVEHTNDERRMLQRVKHPFLITLWGTFQDAKNLYMVMDFIEGGELFSLLRKSQRFPNPVAKFYAAEVALALDYLHSMNIIYRDLKPENLLLDRHGHLKITDFGFAKEVPDITWTLCGTPDYLAPEVVASKGYNKSVDWWSLGILIFEMLCGYTPFWDGGSPMKIYENILRGRVKYPAYIHPDAMNLLQQLITPDLTKRLGNLYHGSRSVLEHPWFAEVNWERLLSKQIEPPYVPPVRGGIGDASLFDKYPEETEEYGKDGPDQYGHFFTDF", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Prot_kinase_dom, Prot_kinase_dom, AGC-kinase_C that are essential for its biological function; 2. The protein should be classified within Kinase-like_dom_sf sharing conserved structural features; 3. The protein must have Ser/Thr_kinase_AS that is conserved among related catalytic enzymes; 4. The protein should include a Protein_kinase_ATP_BS that enables ligand binding under diverse conditions. The designed protein sequence is ", "reference": "MLPDTGILSPFTTAVNPDPPQSQTLRVPRPTPVLDRPTTDSTANKRVKLDPTVSKVPWEPSVKPSSSKVEGASGLEQDSFMPTLGSVFKKKKKDKEATRLKDSSGNPDTIIEDSPVTPSTERSLSQSLGSAPSTATTANSHGGLSTVTSATSQTPTSPIATGGQAEKDHPMTTPVNESAGHSRSDSQTLQKAENAVRATKGKYTLQDFNFQRTLGTGSFGRVHLVQSKHNLRFYAVKVLKKAQVVKMKQVEHTNDERRMLQRVKHPFLITLWGTFQDAKNLYMVMDFIEGGELFSLLRKSQRFPNPVAKFYAAEVALALDYLHSMNIIYRDLKPENLLLDRHGHLKITDFGFAKEVPDITWTLCGTPDYLAPEVVASKGYNKSVDWWSLGILIFEMLCGYTPFWDGGSPMKIYENILRGRVKYPAYIHPDAMNLLQQLITPDLTKRLGNLYHGSRSVLEHPWFAEVNWERLLSKQIEPPYVPPVRGGIGDASLFDKYPEETEEYGKDGPDQYGHFFTDF" }, { "InterPro": [ { "InterPro-ID": "IPR011042", "InterPro-Name": "6-blade_b-propeller_TolB-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 32, "End": 414 }, { "InterPro-ID": "IPR017996", "InterPro-Name": "Royal_jelly/protein_yellow", "InterPro-Type": "FAMILY", "Beg": 77, "End": 98 }, { "InterPro-ID": "IPR017996", "InterPro-Name": "Royal_jelly/protein_yellow", "InterPro-Type": "FAMILY", "Beg": 151, "End": 175 }, { "InterPro-ID": "IPR017996", "InterPro-Name": "Royal_jelly/protein_yellow", "InterPro-Type": "FAMILY", "Beg": 31, "End": 52 }, { "InterPro-ID": "IPR017996", "InterPro-Name": "Royal_jelly/protein_yellow", "InterPro-Type": "FAMILY", "Beg": 210, "End": 227 }, { "InterPro-ID": "IPR017996", "InterPro-Name": "Royal_jelly/protein_yellow", "InterPro-Type": "FAMILY", "Beg": 303, "End": 322 }, { "InterPro-ID": "IPR017996", "InterPro-Name": "Royal_jelly/protein_yellow", "InterPro-Type": "FAMILY", "Beg": 325, "End": 347 }, { "InterPro-ID": "IPR017996", "InterPro-Name": "Royal_jelly/protein_yellow", "InterPro-Type": "FAMILY", "Beg": 53, "End": 75 }, { "InterPro-ID": "IPR017996", "InterPro-Name": "Royal_jelly/protein_yellow", "InterPro-Type": "FAMILY", "Beg": 123, "End": 411 }, { "InterPro-ID": "IPR017996", "InterPro-Name": "Royal_jelly/protein_yellow", "InterPro-Type": "FAMILY", "Beg": 26, "End": 413 } ], "response#1": "MSFNIWWLILYFSIVCQAKAHYSLRDFKANIFQVKYQWKYFDYNFGSDEKRQAAIQSGEYNYKNNVPIDVDRWNGKTFVTILRNDGVPSSLNVISNKIGNGGPLLEPYPNWSWAKNQNCSGITSVYRIAIDEWDRLWVLDNGISGETSVCPSQIVVFDLKNSKLLKQVKIPHDIAINSTTGKRNVVTPIVQSFDYNNTWVYIADVEGYALIIYNNADDSFQRLTSSTFVYDPRYTKYTINDESFSLQDGILGMALSHKTQNLYYSAMSSHNLNYVNTKQFTQGKFQANDIQYQGASDILWTQASAKAISETGALFFGLVSDTALGCWNENRPLKRRNIEIVAKNNDTLQFISGIKIIKQISSNIYERQNNEYIWIVSNKYQKIANGDLNFNEVNFRILNAPVNQLIRYTRCENPKTNFFSIFL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Royal_jelly/protein_yellow, Royal_jelly/protein_yellow, Royal_jelly/protein_yellow, Royal_jelly/protein_yellow, Royal_jelly/protein_yellow, Royal_jelly/protein_yellow, Royal_jelly/protein_yellow, Royal_jelly/protein_yellow, Royal_jelly/protein_yellow that shares evolutionary origin and functional similarity; 2. The protein should be classified within 6-blade_b-propeller_TolB-like sharing conserved structural features. The designed protein sequence is ", "reference": "MSFNIWWLILYFSIVCQAKAHYSLRDFKANIFQVKYQWKYFDYNFGSDEKRQAAIQSGEYNYKNNVPIDVDRWNGKTFVTILRNDGVPSSLNVISNKIGNGGPLLEPYPNWSWAKNQNCSGITSVYRIAIDEWDRLWVLDNGISGETSVCPSQIVVFDLKNSKLLKQVKIPHDIAINSTTGKRNVVTPIVQSFDYNNTWVYIADVEGYALIIYNNADDSFQRLTSSTFVYDPRYTKYTINDESFSLQDGILGMALSHKTQNLYYSAMSSHNLNYVNTKQFTQGKFQANDIQYQGASDILWTQASAKAISETGALFFGLVSDTALGCWNENRPLKRRNIEIVAKNNDTLQFISGIKIIKQISSNIYERQNNEYIWIVSNKYQKIANGDLNFNEVNFRILNAPVNQLIRYTRCENPKTNFFSIFL" }, { "InterPro": [ { "InterPro-ID": "IPR004897", "InterPro-Name": "P/V_Pprotein_paramyxoviral", "InterPro-Type": "FAMILY", "Beg": 235, "End": 387 } ], "response#1": "MDQFIKQDETGDLIETGMNVANHFLSAPIQGTNLLSKATIIPGVAPVLIGNPEQKNIQYPTASHQGSKSKGRSSGAKPIIVSSSEVGTGGTQIPEPLFAQTGQGGTVTTVYQDPTIQPTGSYRSVELAKIGKERMINRFVEKPRTSTPVTEFKRGGPGAAAQGQTIQEEGIDGNGASAGSKERSGSLSGATPYAHLSLPQQDSTPANVGIAQQSAISANEIMDLLRGMDARLQHLEQKVDKVLAQGSMVTQIKNELSTVKTTLATIEGMMATVKIMDPGNPTGVPVDELRRSFSDHVTIVSGPGDVSFSSSEEPTLYLDELARPIPKPRPAKQPKPQPVKDLAGRKVMITKMITDCVANPQMKQAFEQRLAKASTEDALNDIKRDIIRSAI", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to P/V_Pprotein_paramyxoviral that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MDQFIKQDETGDLIETGMNVANHFLSAPIQGTNLLSKATIIPGVAPVLIGNPEQKNIQYPTASHQGSKSKGRSSGAKPIIVSSSEVGTGGTQIPEPLFAQTGQGGTVTTVYQDPTIQPTGSYRSVELAKIGKERMINRFVEKPRTSTPVTEFKRGGPGAAAQGQTIQEEGIDGNGASAGSKERSGSLSGATPYAHLSLPQQDSTPANVGIAQQSAISANEIMDLLRGMDARLQHLEQKVDKVLAQGSMVTQIKNELSTVKTTLATIEGMMATVKIMDPGNPTGVPVDELRRSFSDHVTIVSGPGDVSFSSSEEPTLYLDELARPIPKPRPAKQPKPQPVKDLAGRKVMITKMITDCVANPQMKQAFEQRLAKASTEDALNDIKRDIIRSAI" }, { "InterPro": [ { "InterPro-ID": "IPR042240", "InterPro-Name": "CHASE_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 114, "End": 329 }, { "InterPro-ID": "IPR036097", "InterPro-Name": "HisK_dim/P_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 369, "End": 449 }, { "InterPro-ID": "IPR001789", "InterPro-Name": "Sig_transdc_resp-reg_receiver", "InterPro-Type": "DOMAIN", "Beg": 861, "End": 990 }, { "InterPro-ID": "IPR006189", "InterPro-Name": "CHASE_dom", "InterPro-Type": "DOMAIN", "Beg": 110, "End": 322 }, { "InterPro-ID": "IPR036890", "InterPro-Name": "HATPase_C_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 447, "End": 683 }, { "InterPro-ID": "IPR003661", "InterPro-Name": "HisK_dim/P_dom", "InterPro-Type": "DOMAIN", "Beg": 383, "End": 444 }, { "InterPro-ID": "IPR005467", "InterPro-Name": "His_kinase_dom", "InterPro-Type": "DOMAIN", "Beg": 390, "End": 680 }, { "InterPro-ID": "IPR003594", "InterPro-Name": "HATPase_dom", "InterPro-Type": "DOMAIN", "Beg": 495, "End": 680 }, { "InterPro-ID": "IPR036890", "InterPro-Name": "HATPase_C_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 437, "End": 675 }, { "InterPro-ID": "IPR003594", "InterPro-Name": "HATPase_dom", "InterPro-Type": "DOMAIN", "Beg": 603, "End": 678 }, { "InterPro-ID": "IPR006189", "InterPro-Name": "CHASE_dom", "InterPro-Type": "DOMAIN", "Beg": 110, "End": 295 }, { "InterPro-ID": "IPR056839", "InterPro-Name": "Receiver_AHK4/CRE1_1st", "InterPro-Type": "DOMAIN", "Beg": 698, "End": 836 }, { "InterPro-ID": "IPR050956", "InterPro-Name": "2C_system_His_kinase", "InterPro-Type": "FAMILY", "Beg": 10, "End": 991 }, { "InterPro-ID": "IPR011006", "InterPro-Name": "CheY-like_superfamily", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 860, "End": 995 }, { "InterPro-ID": "IPR001789", "InterPro-Name": "Sig_transdc_resp-reg_receiver", "InterPro-Type": "DOMAIN", "Beg": 862, "End": 994 }, { "InterPro-ID": "IPR004358", "InterPro-Name": "Sig_transdc_His_kin-like_C", "InterPro-Type": "DOMAIN", "Beg": 640, "End": 658 }, { "InterPro-ID": "IPR004358", "InterPro-Name": "Sig_transdc_His_kin-like_C", "InterPro-Type": "DOMAIN", "Beg": 605, "End": 619 }, { "InterPro-ID": "IPR004358", "InterPro-Name": "Sig_transdc_His_kin-like_C", "InterPro-Type": "DOMAIN", "Beg": 664, "End": 677 }, { "InterPro-ID": "IPR004358", "InterPro-Name": "Sig_transdc_His_kin-like_C", "InterPro-Type": "DOMAIN", "Beg": 623, "End": 633 }, { "InterPro-ID": "IPR003661", "InterPro-Name": "HisK_dim/P_dom", "InterPro-Type": "DOMAIN", "Beg": 383, "End": 448 }, { "InterPro-ID": "IPR011006", "InterPro-Name": "CheY-like_superfamily", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 701, "End": 836 }, { "InterPro-ID": "IPR001789", "InterPro-Name": "Sig_transdc_resp-reg_receiver", "InterPro-Type": "DOMAIN", "Beg": 705, "End": 835 }, { "InterPro-ID": "IPR006189", "InterPro-Name": "CHASE_dom", "InterPro-Type": "DOMAIN", "Beg": 113, "End": 293 }, { "InterPro-ID": "IPR001789", "InterPro-Name": "Sig_transdc_resp-reg_receiver", "InterPro-Type": "DOMAIN", "Beg": 863, "End": 990 } ], "response#1": "MGLLLKMKMQNQHHPLASKLQEQTGNKRYTFIQAHRAWLLKLMFLWILLMALISRIIYSKMDVGTKVRRKEVLGSLCDQRARMLQDQFSVSVNHVHALAILVSTFHYYRNPSAIDQETFAEYTARTAFERPLLSGVAYAQRVVNSEREQFEKQHGVVIKTMEREASPVRDEYAPVIFAQETVSYLESIDMMSGEEDRENIMRARATGKAVLTSPFRLLGSHHLGVVLTFPVYKSKLPPNPTTEELIKATAGYVGGSFDVESLVENLLGQLAGHQAILVNVYDVTNSSDPLIMYGNQYEEGDVSLVHESKLDFGDPYRKHQMICRYHQKAPPNWTALSTAILFFVILLLIGYILYGAGNHIVKVEDDFHEMQELKVRAEAADVAKSQFLATVSHEIRTPMNGILGMLGLLLRTELNSTQRDYAQTAQACGKALIALINEVLDRAKIEAGKLELEAVPFDLRSILDDVLSLFSEKSRHKGLELAVFVSDKVPDIVMGDPGRFRQIVTNLVGNSVKFTERGHIFVKVHLSENRKPVTNGKHETYRNGGSEEVVHASGGYNLKTLSGYEAADERNNWDNFNHLIADEEFFCDASTKKVASNEFYEQVTLMVCVEDTGIGIPFSAQDRIFMPFVQADSSTSRNYGGTGIGLSISKCLVELMGGQINFISRPQVGSTFSFTADFGIFKKNPITEVKKVNYEDLPSSFRGLKAVVVDGKPVRAAVTRYHLKRLGIQVKVANAINKAVSLCGKNGASSTGLFQPDIIFVEKDSWVCGEDGIFSVRQLDWKQNGHIFKMPQMILLATNISNDEFDKAKSAGFSDTVIMKPLRASMVGACLQQVLGTGKKRQLGKEMPNGSTSVRSLLFGKKILVVDDNVVNRRVAAGALKNFGADVKCADSGKAALEMLQFPHKFDACFMDIQMPEMDGFEATRRIREMERTANEETNSECGERKSEFHLPILAMTADVIHATYEECLKCGMDGYVSKPFEEENLYQAVAKFFQTKPTSVDS", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Sig_transdc_resp-reg_receiver, CHASE_dom, HisK_dim/P_dom, His_kinase_dom, HATPase_dom, HATPase_dom, CHASE_dom, Receiver_AHK4/CRE1_1st, Sig_transdc_resp-reg_receiver, Sig_transdc_His_kin-like_C, Sig_transdc_His_kin-like_C, Sig_transdc_His_kin-like_C, Sig_transdc_His_kin-like_C, HisK_dim/P_dom, Sig_transdc_resp-reg_receiver, CHASE_dom, Sig_transdc_resp-reg_receiver that are essential for its biological function; 2. The protein should belong to 2C_system_His_kinase that shares evolutionary origin and functional similarity; 3. The protein should be classified within CHASE_sf, HisK_dim/P_sf, HATPase_C_sf, HATPase_C_sf, CheY-like_superfamily, CheY-like_superfamily sharing conserved structural features. The designed protein sequence is ", "reference": "MGLLLKMKMQNQHHPLASKLQEQTGNKRYTFIQAHRAWLLKLMFLWILLMALISRIIYSKMDVGTKVRRKEVLGSLCDQRARMLQDQFSVSVNHVHALAILVSTFHYYRNPSAIDQETFAEYTARTAFERPLLSGVAYAQRVVNSEREQFEKQHGVVIKTMEREASPVRDEYAPVIFAQETVSYLESIDMMSGEEDRENIMRARATGKAVLTSPFRLLGSHHLGVVLTFPVYKSKLPPNPTTEELIKATAGYVGGSFDVESLVENLLGQLAGHQAILVNVYDVTNSSDPLIMYGNQYEEGDVSLVHESKLDFGDPYRKHQMICRYHQKAPPNWTALSTAILFFVILLLIGYILYGAGNHIVKVEDDFHEMQELKVRAEAADVAKSQFLATVSHEIRTPMNGILGMLGLLLRTELNSTQRDYAQTAQACGKALIALINEVLDRAKIEAGKLELEAVPFDLRSILDDVLSLFSEKSRHKGLELAVFVSDKVPDIVMGDPGRFRQIVTNLVGNSVKFTERGHIFVKVHLSENRKPVTNGKHETYRNGGSEEVVHASGGYNLKTLSGYEAADERNNWDNFNHLIADEEFFCDASTKKVASNEFYEQVTLMVCVEDTGIGIPFSAQDRIFMPFVQADSSTSRNYGGTGIGLSISKCLVELMGGQINFISRPQVGSTFSFTADFGIFKKNPITEVKKVNYEDLPSSFRGLKAVVVDGKPVRAAVTRYHLKRLGIQVKVANAINKAVSLCGKNGASSTGLFQPDIIFVEKDSWVCGEDGIFSVRQLDWKQNGHIFKMPQMILLATNISNDEFDKAKSAGFSDTVIMKPLRASMVGACLQQVLGTGKKRQLGKEMPNGSTSVRSLLFGKKILVVDDNVVNRRVAAGALKNFGADVKCADSGKAALEMLQFPHKFDACFMDIQMPEMDGFEATRRIREMERTANEETNSECGERKSEFHLPILAMTADVIHATYEECLKCGMDGYVSKPFEEENLYQAVAKFFQTKPTSVDS" }, { "InterPro": [ { "InterPro-ID": "IPR001138", "InterPro-Name": "Zn2Cys6_DnaBD", "InterPro-Type": "DOMAIN", "Beg": 12, "End": 46 }, { "InterPro-ID": "IPR001138", "InterPro-Name": "Zn2Cys6_DnaBD", "InterPro-Type": "DOMAIN", "Beg": 9, "End": 47 }, { "InterPro-ID": "IPR036864", "InterPro-Name": "Zn2-C6_fun-type_DNA-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 9, "End": 69 }, { "InterPro-ID": "IPR036864", "InterPro-Name": "Zn2-C6_fun-type_DNA-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 8, "End": 54 } ], "response#1": "MQQTAALPKRLSCDRCYAQKLRCPRPSTNDDASCIRCLRQKVQCVYSTALPKGRPRAAVRACAAGAGATAGAPPITTTTTTAAPSSSDTAPPIFSTEDLASLTGLSTSGWLPDPTWEDSFCFLSSQVVPQPPPLDTTPPPRSLSASGLDNPENCVGRLSDLATRLHAVYQTTRALSDHPLITNAAFEAVTTLFNAPLSPPSAATTAATTNLRETFTSSRHLLETISHLLWATPNNNPSTAPAAAADETVIYHFTIACYSLLLLIYATLLTALHRDALTHTQPSLSTTTTTTGPDNNTSTWCSAPSLVELRLVLLFHMITYFLDRLQQMIRMYTAEFEKQASNSTTGRRPPTSGRWSEEVEEMMVVEEPWEREQHIPPPPPPTSSLGSISELETQARAALMQLRMSLVATRGGLVDN", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Zn2Cys6_DnaBD, Zn2Cys6_DnaBD that are essential for its biological function; 2. The protein should be classified within Zn2-C6_fun-type_DNA-bd_sf, Zn2-C6_fun-type_DNA-bd_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MQQTAALPKRLSCDRCYAQKLRCPRPSTNDDASCIRCLRQKVQCVYSTALPKGRPRAAVRACAAGAGATAGAPPITTTTTTAAPSSSDTAPPIFSTEDLASLTGLSTSGWLPDPTWEDSFCFLSSQVVPQPPPLDTTPPPRSLSASGLDNPENCVGRLSDLATRLHAVYQTTRALSDHPLITNAAFEAVTTLFNAPLSPPSAATTAATTNLRETFTSSRHLLETISHLLWATPNNNPSTAPAAAADETVIYHFTIACYSLLLLIYATLLTALHRDALTHTQPSLSTTTTTTGPDNNTSTWCSAPSLVELRLVLLFHMITYFLDRLQQMIRMYTAEFEKQASNSTTGRRPPTSGRWSEEVEEMMVVEEPWEREQHIPPPPPPTSSLGSISELETQARAALMQLRMSLVATRGGLVDN" }, { "InterPro": [ { "InterPro-ID": "IPR013788", "InterPro-Name": "Hemocyanin/hexamerin", "InterPro-Type": "FAMILY", "Beg": 23, "End": 681 }, { "InterPro-ID": "IPR036697", "InterPro-Name": "Hemocyanin_N_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 31, "End": 160 }, { "InterPro-ID": "IPR036697", "InterPro-Name": "Hemocyanin_N_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 35, "End": 159 }, { "InterPro-ID": "IPR005204", "InterPro-Name": "Hemocyanin_N", "InterPro-Type": "DOMAIN", "Beg": 33, "End": 155 }, { "InterPro-ID": "IPR008922", "InterPro-Name": "Di-copper_centre_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 160, "End": 434 }, { "InterPro-ID": "IPR005203", "InterPro-Name": "Hemocyanin_C", "InterPro-Type": "DOMAIN", "Beg": 438, "End": 674 }, { "InterPro-ID": "IPR037020", "InterPro-Name": "Hemocyanin_C_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 436, "End": 683 }, { "InterPro-ID": "IPR013788", "InterPro-Name": "Hemocyanin/hexamerin", "InterPro-Type": "FAMILY", "Beg": 219, "End": 232 }, { "InterPro-ID": "IPR013788", "InterPro-Name": "Hemocyanin/hexamerin", "InterPro-Type": "FAMILY", "Beg": 233, "End": 250 }, { "InterPro-ID": "IPR013788", "InterPro-Name": "Hemocyanin/hexamerin", "InterPro-Type": "FAMILY", "Beg": 265, "End": 277 }, { "InterPro-ID": "IPR013788", "InterPro-Name": "Hemocyanin/hexamerin", "InterPro-Type": "FAMILY", "Beg": 414, "End": 429 }, { "InterPro-ID": "IPR008922", "InterPro-Name": "Di-copper_centre_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 161, "End": 434 }, { "InterPro-ID": "IPR000896", "InterPro-Name": "Hemocyanin/hexamerin_mid_dom", "InterPro-Type": "DOMAIN", "Beg": 161, "End": 429 }, { "InterPro-ID": "IPR014756", "InterPro-Name": "Ig_E-set", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 438, "End": 676 } ], "response#1": "MFIPSHQVWLVGLLAFSLVGAEYYDTKTADKDFLLKQKKVYNLLYRVAQPALANITWYNEGQAWNIEANIDSYTNAAAVKEFLSIYKHGMLPRGELFSLYYPQLLREMSALFKLFYHAKDFDIFFKTALWAKNNINEAQYIYSLYTAVITRPDTKFIQLPPLYEMCPYFFFNSEVLQKANHALIFGKLDTKTSGKYKEYIIPANYSGWYLNHDYNLENKLIYFIEDIGLNTYYFFLRQAFPFWLPSKEYDLPDYRGEEYLYSHKLLLNRYYLERLSNDLPHLEEFDWQKPFYPGYYPTMTYSNGLPFPQRPIWSNFPIYKYKYIREIMNKESRISAAIDSGYILNNDGKWHNIYSEKGLNILGNIIEGNADSYNTEFYGSIDTLARKILGYNLEAASKYQIVPSALEIFSTSMKDPAFYRIYKRIIDYYHSYKMHQKPYNKDEIIYPNLKIESFTVDKLITYFEQFDTTINNGLLLEEQRNDDKPFLIKIRQYRLNHKPFNFHITINADKPMKAAIRIFIGPKYDSHHKLIEIPEDLKYFYEIDNWMLDLNSGLNKITRNSLDCFFTMNDLEPSEIFYEKIETSLNSDKPFTYNERIFGFPGRLLLPRGKKEGMPFQLFLYVSPVSSEYNQYNSRIWGGYKFDKRSFGFPLDKPLYDFNYEGPNMLFKDILIYHKDEFDMNITY", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Hemocyanin_N, Hemocyanin_C, Hemocyanin/hexamerin_mid_dom that are essential for its biological function; 2. The protein should belong to Hemocyanin/hexamerin, Hemocyanin/hexamerin, Hemocyanin/hexamerin, Hemocyanin/hexamerin, Hemocyanin/hexamerin that shares evolutionary origin and functional similarity; 3. The protein should be classified within Hemocyanin_N_sf, Hemocyanin_N_sf, Di-copper_centre_dom_sf, Hemocyanin_C_sf, Di-copper_centre_dom_sf, Ig_E-set sharing conserved structural features. The designed protein sequence is ", "reference": "MFIPSHQVWLVGLLAFSLVGAEYYDTKTADKDFLLKQKKVYNLLYRVAQPALANITWYNEGQAWNIEANIDSYTNAAAVKEFLSIYKHGMLPRGELFSLYYPQLLREMSALFKLFYHAKDFDIFFKTALWAKNNINEAQYIYSLYTAVITRPDTKFIQLPPLYEMCPYFFFNSEVLQKANHALIFGKLDTKTSGKYKEYIIPANYSGWYLNHDYNLENKLIYFIEDIGLNTYYFFLRQAFPFWLPSKEYDLPDYRGEEYLYSHKLLLNRYYLERLSNDLPHLEEFDWQKPFYPGYYPTMTYSNGLPFPQRPIWSNFPIYKYKYIREIMNKESRISAAIDSGYILNNDGKWHNIYSEKGLNILGNIIEGNADSYNTEFYGSIDTLARKILGYNLEAASKYQIVPSALEIFSTSMKDPAFYRIYKRIIDYYHSYKMHQKPYNKDEIIYPNLKIESFTVDKLITYFEQFDTTINNGLLLEEQRNDDKPFLIKIRQYRLNHKPFNFHITINADKPMKAAIRIFIGPKYDSHHKLIEIPEDLKYFYEIDNWMLDLNSGLNKITRNSLDCFFTMNDLEPSEIFYEKIETSLNSDKPFTYNERIFGFPGRLLLPRGKKEGMPFQLFLYVSPVSSEYNQYNSRIWGGYKFDKRSFGFPLDKPLYDFNYEGPNMLFKDILIYHKDEFDMNITY" }, { "InterPro": [ { "InterPro-ID": "IPR051483", "InterPro-Name": "MAP7_domain-containing", "InterPro-Type": "FAMILY", "Beg": 83, "End": 804 }, { "InterPro-ID": "IPR008604", "InterPro-Name": "MAP7_fam", "InterPro-Type": "FAMILY", "Beg": 597, "End": 735 } ], "response#1": "MESGPRVEPGPGAPAAVLARIPQEPRPSPEGDPSPPPPPTPMSALVPDTPPDTPPAMKNASTPQQLPLEPVSPTGQVSPQPAPPPDECPSSEAKSRGPTPTATGPRDAKPSQRSSQPSPTAVPASDSPSAKQDVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQRLKAEQRRAALEERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQRWSWAGALHHNSPGRKTSGSRCSVSAVNLPKHVDSIINKRLSKSSATLWNSPSRNRSLQLSAWESSIVDRLMTPTLSFLARSRSAVTLPRNGRDQGRGSGPGRRPTRARAGASLAPGPHPDRTHPSAAVPVCPRSASASPLTPCSAPRSAHRCTPSGERPERRKPGAGGSPALVRRRLEATPVQKKEKKDKERENEKEKSALARERNLKKRQSLPASIRPRISTGAELSTKSKARPTSPSTTWHRPASPCPSPGPGHTLPPKPPSPRGTTASPKGRIRRKEEAKESPSPSGPEDKNHSKSRTAEEKEPAAPASPAPSPVPSPTPAQPQKEQSSTQIPPDTAVPAVPTVPTFPTAPPTAAPSVTPSKPMAGTTDREEATRLLAEKRRQAREQREREEQERKLQAERDKRMREEQLAREAEARAEREAEARRREEQEAREKAQAEQEEQERLQKQKEEAEARSREEAERQRLEREKHFQKEEQERQERRKRLEEIMKRTRKSEAAETKKQDGKETMANNSGPDPVKAVETRPSGLQKDSMQKEELAPQEPQWSLPSKEMPGSLVNGLQPLPAHQENGFPAKGTAGDKSLGRAAEGLLPFAEADAFLKKAVVQPPQVTEVL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to MAP7_domain-containing, MAP7_fam that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MESGPRVEPGPGAPAAVLARIPQEPRPSPEGDPSPPPPPTPMSALVPDTPPDTPPAMKNASTPQQLPLEPVSPTGQVSPQPAPPPDECPSSEAKSRGPTPTATGPRDAKPSQRSSQPSPTAVPASDSPSAKQDVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQRLKAEQRRAALEERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQRWSWAGALHHNSPGRKTSGSRCSVSAVNLPKHVDSIINKRLSKSSATLWNSPSRNRSLQLSAWESSIVDRLMTPTLSFLARSRSAVTLPRNGRDQGRGSGPGRRPTRARAGASLAPGPHPDRTHPSAAVPVCPRSASASPLTPCSAPRSAHRCTPSGERPERRKPGAGGSPALVRRRLEATPVQKKEKKDKERENEKEKSALARERNLKKRQSLPASIRPRISTGAELSTKSKARPTSPSTTWHRPASPCPSPGPGHTLPPKPPSPRGTTASPKGRIRRKEEAKESPSPSGPEDKNHSKSRTAEEKEPAAPASPAPSPVPSPTPAQPQKEQSSTQIPPDTAVPAVPTVPTFPTAPPTAAPSVTPSKPMAGTTDREEATRLLAEKRRQAREQREREEQERKLQAERDKRMREEQLAREAEARAEREAEARRREEQEAREKAQAEQEEQERLQKQKEEAEARSREEAERQRLEREKHFQKEEQERQERRKRLEEIMKRTRKSEAAETKKQDGKETMANNSGPDPVKAVETRPSGLQKDSMQKEELAPQEPQWSLPSKEMPGSLVNGLQPLPAHQENGFPAKGTAGDKSLGRAAEGLLPFAEADAFLKKAVVQPPQVTEVL" }, { "InterPro": [ { "InterPro-ID": "IPR006994", "InterPro-Name": "TCF25/Rqc1", "InterPro-Type": "FAMILY", "Beg": 332, "End": 578 }, { "InterPro-ID": "IPR006994", "InterPro-Name": "TCF25/Rqc1", "InterPro-Type": "FAMILY", "Beg": 249, "End": 310 }, { "InterPro-ID": "IPR006994", "InterPro-Name": "TCF25/Rqc1", "InterPro-Type": "FAMILY", "Beg": 1, "End": 663 } ], "response#1": "MSRRALRRLRGEQRGQEPLGPDALQFVLLDDDDAEEEGPKTGLGGRRPGGAGKEGVRVNNRFELINIEDLEDDLVVNGERSDCTLPDSASSGNKGRAKHGNPENKQDGDAAAKAGSSEQSNASGKLRKKKKKQKNKKSCTGESSENGLEDIDRILERIEDSSGFSHPGPPPLSSRKHVLYVEHRHLNPDTELKRYFGARAVLGEQRPRQRQRVYPKCTWLTTPKSTWPRYSKPGLSMRLLESKKGLSFFAFEHSEEYQQAQHKFLVAVESMEPNNIVALLQTSPYHVDSLLQLSDACRFQEDQEMARDLIGEPAYPHLLPMEKSWCRRPHWSFYLALYKQMSFLEKRGCPRTALEYCKLILSLEPDEDPLCMLLLIDHMALRARNYEYLIRLFQEWEAHRNLSQLPNFAFSVPLAYFLLSQQTDLPDHELSSARQQASLLIQQALTMFPGVLMPLLEYCSVRPDATVSNHRFFGPDAEISQPPALSQLVSLYLGRSHFLWKEPAIMSWLEENVHEVLEAVDSGDPAVEACENRRKVLYQRAPRNIHRHVILSEIKEAVAALPSDVTTQSVMGFDPLPPVDTIYSYVRPERLSPVSHGNTIALFFRSLLPNYTTEGERLEEGVAGGPNRNQGLNRLMLAVRDMMANFHFNDLEVPREDNPEGEGDWD", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to TCF25/Rqc1, TCF25/Rqc1, TCF25/Rqc1 that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MSRRALRRLRGEQRGQEPLGPDALQFVLLDDDDAEEEGPKTGLGGRRPGGAGKEGVRVNNRFELINIEDLEDDLVVNGERSDCTLPDSASSGNKGRAKHGNPENKQDGDAAAKAGSSEQSNASGKLRKKKKKQKNKKSCTGESSENGLEDIDRILERIEDSSGFSHPGPPPLSSRKHVLYVEHRHLNPDTELKRYFGARAVLGEQRPRQRQRVYPKCTWLTTPKSTWPRYSKPGLSMRLLESKKGLSFFAFEHSEEYQQAQHKFLVAVESMEPNNIVALLQTSPYHVDSLLQLSDACRFQEDQEMARDLIGEPAYPHLLPMEKSWCRRPHWSFYLALYKQMSFLEKRGCPRTALEYCKLILSLEPDEDPLCMLLLIDHMALRARNYEYLIRLFQEWEAHRNLSQLPNFAFSVPLAYFLLSQQTDLPDHELSSARQQASLLIQQALTMFPGVLMPLLEYCSVRPDATVSNHRFFGPDAEISQPPALSQLVSLYLGRSHFLWKEPAIMSWLEENVHEVLEAVDSGDPAVEACENRRKVLYQRAPRNIHRHVILSEIKEAVAALPSDVTTQSVMGFDPLPPVDTIYSYVRPERLSPVSHGNTIALFFRSLLPNYTTEGERLEEGVAGGPNRNQGLNRLMLAVRDMMANFHFNDLEVPREDNPEGEGDWD" }, { "InterPro": [ { "InterPro-ID": "IPR017996", "InterPro-Name": "Royal_jelly/protein_yellow", "InterPro-Type": "FAMILY", "Beg": 5, "End": 432 }, { "InterPro-ID": "IPR017996", "InterPro-Name": "Royal_jelly/protein_yellow", "InterPro-Type": "FAMILY", "Beg": 34, "End": 55 }, { "InterPro-ID": "IPR017996", "InterPro-Name": "Royal_jelly/protein_yellow", "InterPro-Type": "FAMILY", "Beg": 80, "End": 101 }, { "InterPro-ID": "IPR017996", "InterPro-Name": "Royal_jelly/protein_yellow", "InterPro-Type": "FAMILY", "Beg": 214, "End": 231 }, { "InterPro-ID": "IPR017996", "InterPro-Name": "Royal_jelly/protein_yellow", "InterPro-Type": "FAMILY", "Beg": 5, "End": 30 }, { "InterPro-ID": "IPR017996", "InterPro-Name": "Royal_jelly/protein_yellow", "InterPro-Type": "FAMILY", "Beg": 329, "End": 351 }, { "InterPro-ID": "IPR017996", "InterPro-Name": "Royal_jelly/protein_yellow", "InterPro-Type": "FAMILY", "Beg": 155, "End": 179 }, { "InterPro-ID": "IPR017996", "InterPro-Name": "Royal_jelly/protein_yellow", "InterPro-Type": "FAMILY", "Beg": 307, "End": 326 }, { "InterPro-ID": "IPR017996", "InterPro-Name": "Royal_jelly/protein_yellow", "InterPro-Type": "FAMILY", "Beg": 56, "End": 78 }, { "InterPro-ID": "IPR011042", "InterPro-Name": "6-blade_b-propeller_TolB-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 36, "End": 420 }, { "InterPro-ID": "IPR017996", "InterPro-Name": "Royal_jelly/protein_yellow", "InterPro-Type": "FAMILY", "Beg": 126, "End": 417 } ], "response#1": "MTNWLLLIVCLSIACQDVTSAIHQRKSSKNLEHSMNVIHEWKYIDYDFGSDEKRQAAIQSGEYDYTKNYPFDVDQWHNKTFLAVIRYDGVPSSLNVISEKIGNGGCLLQPYPDWSWANYKDCSGIVSAYKIAIDKFDRLWVLDSGLINNIQLMCSPKLLAFDLNTSKLLKQIEIPHNIAVNASTGMGGPVSLVVQAMDPMNTTVYIADDRGDALIIYQNSDDSFHRLTSKTFDNDLRYSELAVAGESFTVHDGIFGMALSPVTNNLYYSPLTSHSLYYVNMEPFMKSQYEENNIEYEGIQDIFNTQSSAKVMSKNGVLFFGLVNNSAIGCWNEHQPLQRQNMDMVAQNEKTLQMIISVKIIQNLAYSGRMNRIHKNEYMLALSNRMQKIVNNDFNFDEVNFRILGANVNNLIKNTRCAKSNNQNNNQNKYKNQAHLD", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Royal_jelly/protein_yellow, Royal_jelly/protein_yellow, Royal_jelly/protein_yellow, Royal_jelly/protein_yellow, Royal_jelly/protein_yellow, Royal_jelly/protein_yellow, Royal_jelly/protein_yellow, Royal_jelly/protein_yellow, Royal_jelly/protein_yellow, Royal_jelly/protein_yellow that shares evolutionary origin and functional similarity; 2. The protein should be classified within 6-blade_b-propeller_TolB-like sharing conserved structural features. The designed protein sequence is ", "reference": "MTNWLLLIVCLSIACQDVTSAIHQRKSSKNLEHSMNVIHEWKYIDYDFGSDEKRQAAIQSGEYDYTKNYPFDVDQWHNKTFLAVIRYDGVPSSLNVISEKIGNGGCLLQPYPDWSWANYKDCSGIVSAYKIAIDKFDRLWVLDSGLINNIQLMCSPKLLAFDLNTSKLLKQIEIPHNIAVNASTGMGGPVSLVVQAMDPMNTTVYIADDRGDALIIYQNSDDSFHRLTSKTFDNDLRYSELAVAGESFTVHDGIFGMALSPVTNNLYYSPLTSHSLYYVNMEPFMKSQYEENNIEYEGIQDIFNTQSSAKVMSKNGVLFFGLVNNSAIGCWNEHQPLQRQNMDMVAQNEKTLQMIISVKIIQNLAYSGRMNRIHKNEYMLALSNRMQKIVNNDFNFDEVNFRILGANVNNLIKNTRCAKSNNQNNNQNKYKNQAHLD" }, { "InterPro": [ { "InterPro-ID": "IPR036551", "InterPro-Name": "Flavin_trans-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 22, "End": 211 }, { "InterPro-ID": "IPR003382", "InterPro-Name": "Flavoprotein", "InterPro-Type": "DOMAIN", "Beg": 24, "End": 196 }, { "InterPro-ID": "IPR036551", "InterPro-Name": "Flavin_trans-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 22, "End": 199 } ], "response#1": "MAGSEPVSAEGESMAVDAAPRKPRILLAASGSVAAVKFANLCHCFSEWADVRAVSSSGSLHFIDRASMPKDVILYTDEDEWSSWKKLGDSVLHIELRKWADIMVIAPLSANTLGKIAGGLCDNLLTCIVRAWDYSKPFFVAPAMNTLMWNNPFTERHFISIDELGISLIPPVTKRLACGDYGNGAMAEPSTIYSTVRLFYESKAQQGRAVVTLR", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Flavoprotein that are essential for its biological function; 2. The protein should be classified within Flavin_trans-like, Flavin_trans-like sharing conserved structural features. The designed protein sequence is ", "reference": "MAGSEPVSAEGESMAVDAAPRKPRILLAASGSVAAVKFANLCHCFSEWADVRAVSSSGSLHFIDRASMPKDVILYTDEDEWSSWKKLGDSVLHIELRKWADIMVIAPLSANTLGKIAGGLCDNLLTCIVRAWDYSKPFFVAPAMNTLMWNNPFTERHFISIDELGISLIPPVTKRLACGDYGNGAMAEPSTIYSTVRLFYESKAQQGRAVVTLR" }, { "InterPro": [ { "InterPro-ID": "IPR018359", "InterPro-Name": "Bromodomain_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 313, "End": 370 }, { "InterPro-ID": "IPR001487", "InterPro-Name": "Bromodomain", "InterPro-Type": "DOMAIN", "Beg": 308, "End": 378 }, { "InterPro-ID": "IPR000182", "InterPro-Name": "GNAT_dom", "InterPro-Type": "DOMAIN", "Beg": 105, "End": 192 }, { "InterPro-ID": "IPR037800", "InterPro-Name": "GCN5", "InterPro-Type": "FAMILY", "Beg": 52, "End": 397 }, { "InterPro-ID": "IPR000182", "InterPro-Name": "GNAT_dom", "InterPro-Type": "DOMAIN", "Beg": 66, "End": 221 }, { "InterPro-ID": "IPR036427", "InterPro-Name": "Bromodomain-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 284, "End": 401 }, { "InterPro-ID": "IPR001487", "InterPro-Name": "Bromodomain", "InterPro-Type": "DOMAIN", "Beg": 301, "End": 383 }, { "InterPro-ID": "IPR001487", "InterPro-Name": "Bromodomain", "InterPro-Type": "DOMAIN", "Beg": 289, "End": 397 }, { "InterPro-ID": "IPR016181", "InterPro-Name": "Acyl_CoA_acyltransferase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 88, "End": 226 }, { "InterPro-ID": "IPR001487", "InterPro-Name": "Bromodomain", "InterPro-Type": "DOMAIN", "Beg": 311, "End": 324 }, { "InterPro-ID": "IPR001487", "InterPro-Name": "Bromodomain", "InterPro-Type": "DOMAIN", "Beg": 359, "End": 378 }, { "InterPro-ID": "IPR001487", "InterPro-Name": "Bromodomain", "InterPro-Type": "DOMAIN", "Beg": 341, "End": 359 }, { "InterPro-ID": "IPR001487", "InterPro-Name": "Bromodomain", "InterPro-Type": "DOMAIN", "Beg": 325, "End": 341 }, { "InterPro-ID": "IPR036427", "InterPro-Name": "Bromodomain-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 276, "End": 399 } ], "response#1": "MASENNKRKASEEALSPDSQLQSKKARTDSPEREPKSEGGPLGKPPLRIVPFPEKPAVLEERRGEIEFRVVNNDGSRDSFVVLTGLKCIFQKQLPKMPKDYIARLVYDRSHLSIAIVKHPLEVVGGITYRPFNSRRFAEIVFCAISSDQQVKGYGAHLMSHLKDYVKATSPIMHFLTYADNYAIGYFKKQGFTKEITLDKSIWMGYIKDYEGGTIMQCTMLPKIRYLEIGRMLLKQKEAVHAKIRAFSRSHIIHAPPKEWKNGACKIDPLSIPAIKQSGWSPDMDELARQPRHGPNYNQLLHLLNDMQNHSAAWPFTQPVNRDEVPDYYEVIKEPMDLSTMEEKHEKDMYPTPQDFIKDAMLIFDNCRRYNNENTPYAKSANKLEKFMWQQIRNIPEWSVST", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Bromodomain, GNAT_dom, GNAT_dom, Bromodomain, Bromodomain, Bromodomain, Bromodomain, Bromodomain, Bromodomain that are essential for its biological function; 2. The protein should belong to GCN5 that shares evolutionary origin and functional similarity; 3. The protein should be classified within Bromodomain-like_sf, Acyl_CoA_acyltransferase, Bromodomain-like_sf sharing conserved structural features; 4. The protein should contain Bromodomain_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MASENNKRKASEEALSPDSQLQSKKARTDSPEREPKSEGGPLGKPPLRIVPFPEKPAVLEERRGEIEFRVVNNDGSRDSFVVLTGLKCIFQKQLPKMPKDYIARLVYDRSHLSIAIVKHPLEVVGGITYRPFNSRRFAEIVFCAISSDQQVKGYGAHLMSHLKDYVKATSPIMHFLTYADNYAIGYFKKQGFTKEITLDKSIWMGYIKDYEGGTIMQCTMLPKIRYLEIGRMLLKQKEAVHAKIRAFSRSHIIHAPPKEWKNGACKIDPLSIPAIKQSGWSPDMDELARQPRHGPNYNQLLHLLNDMQNHSAAWPFTQPVNRDEVPDYYEVIKEPMDLSTMEEKHEKDMYPTPQDFIKDAMLIFDNCRRYNNENTPYAKSANKLEKFMWQQIRNIPEWSVST" }, { "InterPro": [ { "InterPro-ID": "IPR017996", "InterPro-Name": "Royal_jelly/protein_yellow", "InterPro-Type": "FAMILY", "Beg": 120, "End": 413 }, { "InterPro-ID": "IPR011042", "InterPro-Name": "6-blade_b-propeller_TolB-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 29, "End": 415 }, { "InterPro-ID": "IPR017996", "InterPro-Name": "Royal_jelly/protein_yellow", "InterPro-Type": "FAMILY", "Beg": 326, "End": 348 }, { "InterPro-ID": "IPR017996", "InterPro-Name": "Royal_jelly/protein_yellow", "InterPro-Type": "FAMILY", "Beg": 74, "End": 95 }, { "InterPro-ID": "IPR017996", "InterPro-Name": "Royal_jelly/protein_yellow", "InterPro-Type": "FAMILY", "Beg": 28, "End": 49 }, { "InterPro-ID": "IPR017996", "InterPro-Name": "Royal_jelly/protein_yellow", "InterPro-Type": "FAMILY", "Beg": 304, "End": 323 }, { "InterPro-ID": "IPR017996", "InterPro-Name": "Royal_jelly/protein_yellow", "InterPro-Type": "FAMILY", "Beg": 149, "End": 173 }, { "InterPro-ID": "IPR017996", "InterPro-Name": "Royal_jelly/protein_yellow", "InterPro-Type": "FAMILY", "Beg": 50, "End": 72 }, { "InterPro-ID": "IPR017996", "InterPro-Name": "Royal_jelly/protein_yellow", "InterPro-Type": "FAMILY", "Beg": 211, "End": 228 }, { "InterPro-ID": "IPR017996", "InterPro-Name": "Royal_jelly/protein_yellow", "InterPro-Type": "FAMILY", "Beg": 10, "End": 413 } ], "response#1": "MIRWLLLMYLGITCQGVTDIHSRNLTNSLKVIYEWKYIDYDFGSDEKRQAAIQSGDYNYTMNYLLDTDQWGDKTFVIIMKFNGVPSSLNVITNKTGNGGPLLAPYPDWTWAKNENCSGITSAYKIEIDMCDRLWVLDSGLINNVRSVCPPQLLVFDLNTSQLLKQVKIPHDIAVNTTTEKGALVTLSVQLLSCEVNGSTLVYIGDNEGFALIIYNNSDNSFQRLTSSTFASDPRYTTFTINGESFTLQSGIFGMALSPLTQNLYYSALSSHNLNYVNTEQFVKSQYQANNVHYQGKENILWTQASAKGISDNGVLFFGLVGDTSLACWNENRLLDRRNIEVVAKNKETLQAITGLKVKRRISFILVHGFPLEYEYVLAVSNRIQKVIYGFDFNDVNFRILIANVNDLIKNTRCISP", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Royal_jelly/protein_yellow, Royal_jelly/protein_yellow, Royal_jelly/protein_yellow, Royal_jelly/protein_yellow, Royal_jelly/protein_yellow, Royal_jelly/protein_yellow, Royal_jelly/protein_yellow, Royal_jelly/protein_yellow, Royal_jelly/protein_yellow that shares evolutionary origin and functional similarity; 2. The protein should be classified within 6-blade_b-propeller_TolB-like sharing conserved structural features. The designed protein sequence is ", "reference": "MIRWLLLMYLGITCQGVTDIHSRNLTNSLKVIYEWKYIDYDFGSDEKRQAAIQSGDYNYTMNYLLDTDQWGDKTFVIIMKFNGVPSSLNVITNKTGNGGPLLAPYPDWTWAKNENCSGITSAYKIEIDMCDRLWVLDSGLINNVRSVCPPQLLVFDLNTSQLLKQVKIPHDIAVNTTTEKGALVTLSVQLLSCEVNGSTLVYIGDNEGFALIIYNNSDNSFQRLTSSTFASDPRYTTFTINGESFTLQSGIFGMALSPLTQNLYYSALSSHNLNYVNTEQFVKSQYQANNVHYQGKENILWTQASAKGISDNGVLFFGLVGDTSLACWNENRLLDRRNIEVVAKNKETLQAITGLKVKRRISFILVHGFPLEYEYVLAVSNRIQKVIYGFDFNDVNFRILIANVNDLIKNTRCISP" }, { "InterPro": [ { "InterPro-ID": "IPR014756", "InterPro-Name": "Ig_E-set", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 453, "End": 655 }, { "InterPro-ID": "IPR005203", "InterPro-Name": "Hemocyanin_C", "InterPro-Type": "DOMAIN", "Beg": 455, "End": 648 }, { "InterPro-ID": "IPR008922", "InterPro-Name": "Di-copper_centre_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 157, "End": 452 }, { "InterPro-ID": "IPR014756", "InterPro-Name": "Ig_E-set", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 950, "End": 1001 }, { "InterPro-ID": "IPR013788", "InterPro-Name": "Hemocyanin/hexamerin", "InterPro-Type": "FAMILY", "Beg": 5, "End": 652 }, { "InterPro-ID": "IPR037020", "InterPro-Name": "Hemocyanin_C_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 941, "End": 1010 }, { "InterPro-ID": "IPR037020", "InterPro-Name": "Hemocyanin_C_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 452, "End": 677 }, { "InterPro-ID": "IPR005204", "InterPro-Name": "Hemocyanin_N", "InterPro-Type": "DOMAIN", "Beg": 30, "End": 151 }, { "InterPro-ID": "IPR036697", "InterPro-Name": "Hemocyanin_N_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 27, "End": 156 }, { "InterPro-ID": "IPR000896", "InterPro-Name": "Hemocyanin/hexamerin_mid_dom", "InterPro-Type": "DOMAIN", "Beg": 157, "End": 445 }, { "InterPro-ID": "IPR008922", "InterPro-Name": "Di-copper_centre_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 157, "End": 451 }, { "InterPro-ID": "IPR013788", "InterPro-Name": "Hemocyanin/hexamerin", "InterPro-Type": "FAMILY", "Beg": 430, "End": 445 }, { "InterPro-ID": "IPR013788", "InterPro-Name": "Hemocyanin/hexamerin", "InterPro-Type": "FAMILY", "Beg": 208, "End": 221 }, { "InterPro-ID": "IPR036697", "InterPro-Name": "Hemocyanin_N_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 19, "End": 153 } ], "response#1": "MRYFIILLALVALGVCAPNVKQRAADQDLLNKQQDVIQLLQKISQPIPNQELQNLGASYDIESNSHQYKNPIIVMYYAGAVKAGLVQPQGTTFSNSISQLRKEVSLLYRILLGAKDYQTFLKTAAWARVHVNEGQFLKAFVAAVLTRQDTQSVIFPPVYEILPQHHLDSRVIQEAQNIAIQNTQGKNNQQNILIPVNYSALLSHDEQQLSYFTQDIGLAAYYAQVNLAGYIQEQNQQQQQQPLTQQQYQQQIVGKYLQQQAGQQDQQANIGRGAQYLYLHQQLLARYELNRLSNGLGPIKDIDYENVQSLYQPHLRGLNGLEFAGRPQNLQLQSQRNQLIQYVATLEKRLRDAIDSGNVITPQGVFLSLYQPQGMNILGDLIEGTGRSVNPRYYGSLQAAARKLLGNAPEVENIWDYTPSSLELGEVAVHDPVFYQLYKKVMNLYQQYQQSLPVYQYNDLILPGVTIQNVDVSQLVTLFTDFYVDLDAVTGHQSQQQQEEQTQSRVRAHLKRLDHQPYQYKIAVHSEQNVPGAVVRVFLGPKHDHQGRPISISKNQHLFVELDQFIQNLHAGENTIIRNSQQAPGQSPDWPSTSQIQRGVNAAIRSQEPFYITEPHQIFSFPARLSLPKGQPQGFPLQFLVVISSSNPLNVPYGPVIPEQSLTYQDQQYQVVSVEQYQQLKEQGQISQVGGGIQQNVEVLPENLVNAQQQVQAVRNYYANLYTKYHGQYPNTQIQNPVGQGQDMTYSVQGVGVVNAGGWLGQQGNSWSQQQVQQAQQVQQQMQAAMAAVQQSQQRHQHAAQMIYGHQQSHHGLHINSSPSSVQSGQQQQSVLQGLGVQGVQQGVQGVQTAQGVQGVQGVQGVQGVQGVQGVQGVPGLLQGVQQVFGQGVQGMNVPYGMQRGQSGGQTWSNSQVQGVAVPGSGIVASGQQHAGGWQSIYAQPQTVQDQIVSEYYQNKPISEVIGGAISLDGKPLGFPLDRPLSLGALSVPNIFVKDVLVFHQGQPTNDITQ", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Hemocyanin_C, Hemocyanin_N, Hemocyanin/hexamerin_mid_dom that are essential for its biological function; 2. The protein should belong to Hemocyanin/hexamerin, Hemocyanin/hexamerin, Hemocyanin/hexamerin that shares evolutionary origin and functional similarity; 3. The protein should be classified within Ig_E-set, Di-copper_centre_dom_sf, Ig_E-set, Hemocyanin_C_sf, Hemocyanin_C_sf, Hemocyanin_N_sf, Di-copper_centre_dom_sf, Hemocyanin_N_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MRYFIILLALVALGVCAPNVKQRAADQDLLNKQQDVIQLLQKISQPIPNQELQNLGASYDIESNSHQYKNPIIVMYYAGAVKAGLVQPQGTTFSNSISQLRKEVSLLYRILLGAKDYQTFLKTAAWARVHVNEGQFLKAFVAAVLTRQDTQSVIFPPVYEILPQHHLDSRVIQEAQNIAIQNTQGKNNQQNILIPVNYSALLSHDEQQLSYFTQDIGLAAYYAQVNLAGYIQEQNQQQQQQPLTQQQYQQQIVGKYLQQQAGQQDQQANIGRGAQYLYLHQQLLARYELNRLSNGLGPIKDIDYENVQSLYQPHLRGLNGLEFAGRPQNLQLQSQRNQLIQYVATLEKRLRDAIDSGNVITPQGVFLSLYQPQGMNILGDLIEGTGRSVNPRYYGSLQAAARKLLGNAPEVENIWDYTPSSLELGEVAVHDPVFYQLYKKVMNLYQQYQQSLPVYQYNDLILPGVTIQNVDVSQLVTLFTDFYVDLDAVTGHQSQQQQEEQTQSRVRAHLKRLDHQPYQYKIAVHSEQNVPGAVVRVFLGPKHDHQGRPISISKNQHLFVELDQFIQNLHAGENTIIRNSQQAPGQSPDWPSTSQIQRGVNAAIRSQEPFYITEPHQIFSFPARLSLPKGQPQGFPLQFLVVISSSNPLNVPYGPVIPEQSLTYQDQQYQVVSVEQYQQLKEQGQISQVGGGIQQNVEVLPENLVNAQQQVQAVRNYYANLYTKYHGQYPNTQIQNPVGQGQDMTYSVQGVGVVNAGGWLGQQGNSWSQQQVQQAQQVQQQMQAAMAAVQQSQQRHQHAAQMIYGHQQSHHGLHINSSPSSVQSGQQQQSVLQGLGVQGVQQGVQGVQTAQGVQGVQGVQGVQGVQGVQGVQGVPGLLQGVQQVFGQGVQGMNVPYGMQRGQSGGQTWSNSQVQGVAVPGSGIVASGQQHAGGWQSIYAQPQTVQDQIVSEYYQNKPISEVIGGAISLDGKPLGFPLDRPLSLGALSVPNIFVKDVLVFHQGQPTNDITQ" }, { "InterPro": [ { "InterPro-ID": "IPR005123", "InterPro-Name": "Oxoglu/Fe-dep_dioxygenase_dom", "InterPro-Type": "DOMAIN", "Beg": 222, "End": 352 }, { "InterPro-ID": "IPR004574", "InterPro-Name": "Alkb", "InterPro-Type": "FAMILY", "Beg": 78, "End": 351 }, { "InterPro-ID": "IPR027450", "InterPro-Name": "AlkB-like", "InterPro-Type": "DOMAIN", "Beg": 159, "End": 349 }, { "InterPro-ID": "IPR037151", "InterPro-Name": "AlkB-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 149, "End": 352 } ], "response#1": "MTVNLTELDAHEQPSDQMRAIWKSYSRADKEELLLNGAIDDLEKPEKAAEFVVAGTVPAATLTKGFAFLGSGFDAAASDAPIYYHPLLPGLLIFPSIVPLEVQKTLLSKLIHRDLSVPAHQTNMHLHYELPYVERKPTDGEGEPEDCRQSFFSHSPDSPVRFQPKDPDVHKPLSMKQVMDRRLHWVTLGGQYDWTNRVYPEEEPPKFPPDVAGFLETVFPDTIAQAAIVNFYTPGDTMMMHRDVSEETDKGLVSLSLGCDGLFMIAPSDIGKMSEEERPEDVKKQYLLLRLRSGDAIYMIKESRYAWHGVPKVLKGTCPEALEDWPAEDGRFEEWRGWMKNKRINLNVRQMRE", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Oxoglu/Fe-dep_dioxygenase_dom, AlkB-like that are essential for its biological function; 2. The protein should belong to Alkb that shares evolutionary origin and functional similarity; 3. The protein should be classified within AlkB-like_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MTVNLTELDAHEQPSDQMRAIWKSYSRADKEELLLNGAIDDLEKPEKAAEFVVAGTVPAATLTKGFAFLGSGFDAAASDAPIYYHPLLPGLLIFPSIVPLEVQKTLLSKLIHRDLSVPAHQTNMHLHYELPYVERKPTDGEGEPEDCRQSFFSHSPDSPVRFQPKDPDVHKPLSMKQVMDRRLHWVTLGGQYDWTNRVYPEEEPPKFPPDVAGFLETVFPDTIAQAAIVNFYTPGDTMMMHRDVSEETDKGLVSLSLGCDGLFMIAPSDIGKMSEEERPEDVKKQYLLLRLRSGDAIYMIKESRYAWHGVPKVLKGTCPEALEDWPAEDGRFEEWRGWMKNKRINLNVRQMRE" }, { "InterPro": [ { "InterPro-ID": "IPR005112", "InterPro-Name": "dDENN_dom", "InterPro-Type": "DOMAIN", "Beg": 975, "End": 1023 }, { "InterPro-ID": "IPR001194", "InterPro-Name": "cDENN_dom", "InterPro-Type": "DOMAIN", "Beg": 435, "End": 632 }, { "InterPro-ID": "IPR051696", "InterPro-Name": "DENN_Domain_GEFs", "InterPro-Type": "FAMILY", "Beg": 938, "End": 1115 }, { "InterPro-ID": "IPR043153", "InterPro-Name": "DENN_C", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 527, "End": 667 }, { "InterPro-ID": "IPR002219", "InterPro-Name": "PE/DAG-bd", "InterPro-Type": "DOMAIN", "Beg": 883, "End": 931 }, { "InterPro-ID": "IPR037516", "InterPro-Name": "Tripartite_DENN", "InterPro-Type": "DOMAIN", "Beg": 246, "End": 1016 }, { "InterPro-ID": "IPR005112", "InterPro-Name": "dDENN_dom", "InterPro-Type": "DOMAIN", "Beg": 936, "End": 1008 }, { "InterPro-ID": "IPR046349", "InterPro-Name": "C1-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 875, "End": 933 }, { "InterPro-ID": "IPR005113", "InterPro-Name": "uDENN_dom", "InterPro-Type": "DOMAIN", "Beg": 262, "End": 328 }, { "InterPro-ID": "IPR005113", "InterPro-Name": "uDENN_dom", "InterPro-Type": "DOMAIN", "Beg": 231, "End": 330 } ], "response#1": "MDSSSTTPLADYFWIAGIETIAYDDPLPSGSQVAASIAEDGEQQPEENGVNANGTGAPRHHARHSRQNSANRLSNSRFSIHTLDEIDGNTQSNRSSVTIRPAHAQGNGLPNEGVGPAPGIGLLDGFDFDDALVKFAAERENFLDDLTFSAGAKLQARPPMVNPRAERIKAEDSDQSGRRSPLRNLERSIKGSIRRKMSFRDMNSSRRQPVTPRASTPGAGAIPRQGSIRTTRRLSNYNSVIPPPEPLNTDPNMHPLKRRFEPVLLDRYPAKDVPEETARRGKFPDYVPMFAFPNDIQIVSSDDRPRSTWHGFTMTSDDNSKIYGITIIIWTALTSDVAEELEKRCEQWRQRHMSNEERELAASLGVRLAAERANLSSLLARLPSVPSGSSARDALDDQISTVEEKISLMTEMLRPLRHGAASKIDGLTAGESGLWSPRAYGILGRDVTRMAFWKDWLRAVLVPMTDGGVLRIPPSSPKVGRWQPLERYVVNLCTEAFSPLGSKTQVELGVRELKLYARQDAVNEIPGSRTIDIYALFRCLSLDNIVALFEYAMSESRIIFLSSHTGMLHLACHALVNLLYPLKWASIFIPVLPARLLSALEAPCPYIVGVERRYERIELPEDDYVLVDLDKDTIDATSQPVRLPRQHRRKLHALLQVAAPAKLRYGVATGPPPYAMESFPYDAFSAENPSLYNDYASPSTLAQWVAQNSSTFGEPSPASEVKPPIFNAFLHSKVDPNKPDRPGTSKSTRTSPPSSVSPVSINFPPMPTTPVSRSDSGFALTSTLREKRSRNFDEKTRRSSSFGVDKHGPLHRPSIPFLNGNGHAPSMSISAISVDSQPYTHSSYGGGYAPSTYAQSTLAASTIMPNMLIQPVFNTETTVWVEGHCFNWEEGALSSSCSVCDDRAEGDGIYKCSGCSAFAHGRCLGCVSLACHQSFYPDRVRAAFVRCLASLLYTYRKHLGRPSKDQKNNGRMYAFDMDGFIKSLPYDQQEYANMMRETQAFNEFIHERETKPGTTASIRFFDEVIMAKKARGRPGIVSGLSRLSTIRSSHGASSNSSAFSPPSRLKIPTYLSDTSDHMWRTASVPVPSAKFPGDYRSIVTRIPARLDTSLMREPRVIQGVPRPEQRGTRGLVRKQVPSMLGTSPTN", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more dDENN_dom, cDENN_dom, PE/DAG-bd, Tripartite_DENN, dDENN_dom, uDENN_dom, uDENN_dom that are essential for its biological function; 2. The protein should belong to DENN_Domain_GEFs that shares evolutionary origin and functional similarity; 3. The protein should be classified within DENN_C, C1-like_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MDSSSTTPLADYFWIAGIETIAYDDPLPSGSQVAASIAEDGEQQPEENGVNANGTGAPRHHARHSRQNSANRLSNSRFSIHTLDEIDGNTQSNRSSVTIRPAHAQGNGLPNEGVGPAPGIGLLDGFDFDDALVKFAAERENFLDDLTFSAGAKLQARPPMVNPRAERIKAEDSDQSGRRSPLRNLERSIKGSIRRKMSFRDMNSSRRQPVTPRASTPGAGAIPRQGSIRTTRRLSNYNSVIPPPEPLNTDPNMHPLKRRFEPVLLDRYPAKDVPEETARRGKFPDYVPMFAFPNDIQIVSSDDRPRSTWHGFTMTSDDNSKIYGITIIIWTALTSDVAEELEKRCEQWRQRHMSNEERELAASLGVRLAAERANLSSLLARLPSVPSGSSARDALDDQISTVEEKISLMTEMLRPLRHGAASKIDGLTAGESGLWSPRAYGILGRDVTRMAFWKDWLRAVLVPMTDGGVLRIPPSSPKVGRWQPLERYVVNLCTEAFSPLGSKTQVELGVRELKLYARQDAVNEIPGSRTIDIYALFRCLSLDNIVALFEYAMSESRIIFLSSHTGMLHLACHALVNLLYPLKWASIFIPVLPARLLSALEAPCPYIVGVERRYERIELPEDDYVLVDLDKDTIDATSQPVRLPRQHRRKLHALLQVAAPAKLRYGVATGPPPYAMESFPYDAFSAENPSLYNDYASPSTLAQWVAQNSSTFGEPSPASEVKPPIFNAFLHSKVDPNKPDRPGTSKSTRTSPPSSVSPVSINFPPMPTTPVSRSDSGFALTSTLREKRSRNFDEKTRRSSSFGVDKHGPLHRPSIPFLNGNGHAPSMSISAISVDSQPYTHSSYGGGYAPSTYAQSTLAASTIMPNMLIQPVFNTETTVWVEGHCFNWEEGALSSSCSVCDDRAEGDGIYKCSGCSAFAHGRCLGCVSLACHQSFYPDRVRAAFVRCLASLLYTYRKHLGRPSKDQKNNGRMYAFDMDGFIKSLPYDQQEYANMMRETQAFNEFIHERETKPGTTASIRFFDEVIMAKKARGRPGIVSGLSRLSTIRSSHGASSNSSAFSPPSRLKIPTYLSDTSDHMWRTASVPVPSAKFPGDYRSIVTRIPARLDTSLMREPRVIQGVPRPEQRGTRGLVRKQVPSMLGTSPTN" }, { "InterPro": [ { "InterPro-ID": "IPR004574", "InterPro-Name": "Alkb", "InterPro-Type": "FAMILY", "Beg": 47, "End": 221 }, { "InterPro-ID": "IPR037151", "InterPro-Name": "AlkB-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 28, "End": 223 }, { "InterPro-ID": "IPR005123", "InterPro-Name": "Oxoglu/Fe-dep_dioxygenase_dom", "InterPro-Type": "DOMAIN", "Beg": 93, "End": 222 }, { "InterPro-ID": "IPR027450", "InterPro-Name": "AlkB-like", "InterPro-Type": "DOMAIN", "Beg": 36, "End": 219 } ], "response#1": "MHLHYDLPYPKHDMTDEPVSFFTYPPDSDTKFIPKDPCVHKPLSIKQVMERKLHWITLGGQYDWTNRVYPGERPPEFPRDVAGLLETLFPETLAQAAIVNFYTPGDTMMMHRDVSEETDKGLVSLSMGCDALFMIAPNDVGKMSEEDRPGHGEKEHLLLRIRSGDAIYMTQEARYAWHGVPKVLKGTCPDYLEDWPAEDGKYEEWQGWMKNKRINLNVRQMRDC", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Oxoglu/Fe-dep_dioxygenase_dom, AlkB-like that are essential for its biological function; 2. The protein should belong to Alkb that shares evolutionary origin and functional similarity; 3. The protein should be classified within AlkB-like_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MHLHYDLPYPKHDMTDEPVSFFTYPPDSDTKFIPKDPCVHKPLSIKQVMERKLHWITLGGQYDWTNRVYPGERPPEFPRDVAGLLETLFPETLAQAAIVNFYTPGDTMMMHRDVSEETDKGLVSLSMGCDALFMIAPNDVGKMSEEDRPGHGEKEHLLLRIRSGDAIYMTQEARYAWHGVPKVLKGTCPDYLEDWPAEDGKYEEWQGWMKNKRINLNVRQMRDC" }, { "InterPro": [ { "InterPro-ID": "IPR020904", "InterPro-Name": "Sc_DH/Rdtase_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 141, "End": 169 }, { "InterPro-ID": "IPR002347", "InterPro-Name": "SDR_fam", "InterPro-Type": "FAMILY", "Beg": 19, "End": 249 }, { "InterPro-ID": "IPR036291", "InterPro-Name": "NAD(P)-bd_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 9, "End": 249 }, { "InterPro-ID": "IPR002347", "InterPro-Name": "SDR_fam", "InterPro-Type": "FAMILY", "Beg": 128, "End": 144 }, { "InterPro-ID": "IPR002347", "InterPro-Name": "SDR_fam", "InterPro-Type": "FAMILY", "Beg": 11, "End": 28 }, { "InterPro-ID": "IPR002347", "InterPro-Name": "SDR_fam", "InterPro-Type": "FAMILY", "Beg": 154, "End": 173 }, { "InterPro-ID": "IPR002347", "InterPro-Name": "SDR_fam", "InterPro-Type": "FAMILY", "Beg": 175, "End": 192 }, { "InterPro-ID": "IPR002347", "InterPro-Name": "SDR_fam", "InterPro-Type": "FAMILY", "Beg": 81, "End": 92 }, { "InterPro-ID": "IPR002347", "InterPro-Name": "SDR_fam", "InterPro-Type": "FAMILY", "Beg": 214, "End": 234 }, { "InterPro-ID": "IPR002347", "InterPro-Name": "SDR_fam", "InterPro-Type": "FAMILY", "Beg": 134, "End": 142 } ], "response#1": "MAAVTRYSGKVVVVTGGSRGIGAAIVRAFVDSGAQVVFCDKDEAGGRALEQELSGTVFIPGDVTQERDLQTLVSETLSRFGHLDCVVNNAGYHPPAQLPEETSAQGFRQLLEVNLLGTYTLIKLALPHLRKSRGNIINISSLVGAIGQSQALTYVATKGAVTAMTKALALDESRHGVRVNCISPGNIWTPLWEELAASTSDPRATILEGTLAQPLGRMGQPAEVAAAAVFLASEATFCTGLELLVTGGAELGYGRKASKSSLGEVPTLPPNVH", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to SDR_fam, SDR_fam, SDR_fam, SDR_fam, SDR_fam, SDR_fam, SDR_fam, SDR_fam that shares evolutionary origin and functional similarity; 2. The protein should be classified within NAD(P)-bd_dom_sf sharing conserved structural features; 3. The protein should contain Sc_DH/Rdtase_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MAAVTRYSGKVVVVTGGSRGIGAAIVRAFVDSGAQVVFCDKDEAGGRALEQELSGTVFIPGDVTQERDLQTLVSETLSRFGHLDCVVNNAGYHPPAQLPEETSAQGFRQLLEVNLLGTYTLIKLALPHLRKSRGNIINISSLVGAIGQSQALTYVATKGAVTAMTKALALDESRHGVRVNCISPGNIWTPLWEELAASTSDPRATILEGTLAQPLGRMGQPAEVAAAAVFLASEATFCTGLELLVTGGAELGYGRKASKSSLGEVPTLPPNVH" }, { "InterPro": [ { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 38, "End": 344 }, { "InterPro-ID": "IPR001019", "InterPro-Name": "Gprotein_alpha_su", "InterPro-Type": "FAMILY", "Beg": 9, "End": 352 }, { "InterPro-ID": "IPR011025", "InterPro-Name": "GproteinA_insert", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 65, "End": 184 }, { "InterPro-ID": "IPR002975", "InterPro-Name": "Fungi_Gprotein_alpha", "InterPro-Type": "FAMILY", "Beg": 189, "End": 199 }, { "InterPro-ID": "IPR002975", "InterPro-Name": "Fungi_Gprotein_alpha", "InterPro-Type": "FAMILY", "Beg": 306, "End": 317 }, { "InterPro-ID": "IPR002975", "InterPro-Name": "Fungi_Gprotein_alpha", "InterPro-Type": "FAMILY", "Beg": 279, "End": 291 }, { "InterPro-ID": "IPR002975", "InterPro-Name": "Fungi_Gprotein_alpha", "InterPro-Type": "FAMILY", "Beg": 62, "End": 74 }, { "InterPro-ID": "IPR002975", "InterPro-Name": "Fungi_Gprotein_alpha", "InterPro-Type": "FAMILY", "Beg": 332, "End": 342 }, { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 35, "End": 353 }, { "InterPro-ID": "IPR001019", "InterPro-Name": "Gprotein_alpha_su", "InterPro-Type": "FAMILY", "Beg": 16, "End": 355 }, { "InterPro-ID": "IPR001019", "InterPro-Name": "Gprotein_alpha_su", "InterPro-Type": "FAMILY", "Beg": 222, "End": 250 }, { "InterPro-ID": "IPR001019", "InterPro-Name": "Gprotein_alpha_su", "InterPro-Type": "FAMILY", "Beg": 171, "End": 193 }, { "InterPro-ID": "IPR001019", "InterPro-Name": "Gprotein_alpha_su", "InterPro-Type": "FAMILY", "Beg": 268, "End": 277 }, { "InterPro-ID": "IPR001019", "InterPro-Name": "Gprotein_alpha_su", "InterPro-Type": "FAMILY", "Beg": 38, "End": 53 }, { "InterPro-ID": "IPR001019", "InterPro-Name": "Gprotein_alpha_su", "InterPro-Type": "FAMILY", "Beg": 200, "End": 217 }, { "InterPro-ID": "IPR001019", "InterPro-Name": "Gprotein_alpha_su", "InterPro-Type": "FAMILY", "Beg": 17, "End": 345 }, { "InterPro-ID": "IPR011025", "InterPro-Name": "GproteinA_insert", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 64, "End": 185 }, { "InterPro-ID": "IPR001019", "InterPro-Name": "Gprotein_alpha_su", "InterPro-Type": "FAMILY", "Beg": 37, "End": 350 }, { "InterPro-ID": "IPR001019", "InterPro-Name": "Gprotein_alpha_su", "InterPro-Type": "FAMILY", "Beg": 35, "End": 356 } ], "response#1": "MGGCMSREASEEMEQRKKSQAIDREIMDDSRRLRRECKILLLGSGESGKSTIVKQMKIIHQNGYTVDELQHYRLTVYKNLVDCAKALIDAMRQFDIVPEHEANKEHMEFLYTFQVDPDPNVPLDLHVSKAVAALWDDPAVPSVLEHQSEFYIMDSAPYFFAEAARIGSPEYIPSEADVLRARTKTTGIYETRFTMGQLNIHMFDVGGQRSERKKWIHCFESVTSIIFCVALSEYDQVLLEEQNQNRMLESLVLFDSVVNSRWFVRTSIILFLNKVDLFRQKLPRTPLSNYFPDYSGGPDVNRAAKYLLWRFNQVNRAHLNLYPHLTQATDTSNIRLVFAAVKETILQNALKDSGIL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Gprotein_alpha_su, Fungi_Gprotein_alpha, Fungi_Gprotein_alpha, Fungi_Gprotein_alpha, Fungi_Gprotein_alpha, Fungi_Gprotein_alpha, Gprotein_alpha_su, Gprotein_alpha_su, Gprotein_alpha_su, Gprotein_alpha_su, Gprotein_alpha_su, Gprotein_alpha_su, Gprotein_alpha_su, Gprotein_alpha_su, Gprotein_alpha_su that shares evolutionary origin and functional similarity; 2. The protein should be classified within P-loop_NTPase, GproteinA_insert, P-loop_NTPase, GproteinA_insert sharing conserved structural features. The designed protein sequence is ", "reference": "MGGCMSREASEEMEQRKKSQAIDREIMDDSRRLRRECKILLLGSGESGKSTIVKQMKIIHQNGYTVDELQHYRLTVYKNLVDCAKALIDAMRQFDIVPEHEANKEHMEFLYTFQVDPDPNVPLDLHVSKAVAALWDDPAVPSVLEHQSEFYIMDSAPYFFAEAARIGSPEYIPSEADVLRARTKTTGIYETRFTMGQLNIHMFDVGGQRSERKKWIHCFESVTSIIFCVALSEYDQVLLEEQNQNRMLESLVLFDSVVNSRWFVRTSIILFLNKVDLFRQKLPRTPLSNYFPDYSGGPDVNRAAKYLLWRFNQVNRAHLNLYPHLTQATDTSNIRLVFAAVKETILQNALKDSGIL" }, { "InterPro": [ { "InterPro-ID": "IPR007275", "InterPro-Name": "YTH_domain", "InterPro-Type": "DOMAIN", "Beg": 307, "End": 513 }, { "InterPro-ID": "IPR007275", "InterPro-Name": "YTH_domain", "InterPro-Type": "DOMAIN", "Beg": 308, "End": 514 }, { "InterPro-ID": "IPR045168", "InterPro-Name": "YTH_prot", "InterPro-Type": "FAMILY", "Beg": 41, "End": 515 }, { "InterPro-ID": "IPR035979", "InterPro-Name": "RBD_domain_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 142, "End": 233 }, { "InterPro-ID": "IPR012677", "InterPro-Name": "Nucleotide-bd_a/b_plait_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 149, "End": 243 }, { "InterPro-ID": "IPR007275", "InterPro-Name": "YTH_domain", "InterPro-Type": "DOMAIN", "Beg": 308, "End": 513 } ], "response#1": "MSQSQVPSRAGHYNMTALANALPQANYRQAPWNNGSQMRYNPAGASPNVVGQTQSSPQYNGQPGMGSMPNQGYYMPQQQQQQQQMPQYYGGPMSPSQPQPNMSSRPNVPFYGNQVMSNHQAHPSMGYYYAQVPAYALQGHPPHQAPVDSQSNVVRGPPRKPRQSGHAIWIGNLPSQTDLMSLVHHVCREAQGLESLFLISKSNCAFANFRDEASCLTAQQKLHESKFQSVRLVSRLRKNTVEGASGITAPTGPSATTPQQAVAPEVKEIEQIDSTETQSDNADTDTPTAVGTPDAKGPAVVDAAQKDRFFVLKSLTVEDLDLSVRTGIWATQSHNEEALNSAFKNAENVYLVFSANKSGEYFGYARMVSTINEDPAAAIEFAPKAQSVNEVDLPREIPTEPTKFTPKGRIIDDSARGTIFWEIAREDSSEGVTQEEPAPAVAEQDDTTGGLDGNSENKTWGKPFKLEWLSTTRLPFYRCRGLRNPWNSNREVKIARDGTELEPSVGRRLIGLFNRSHNSPGPRGPMMGMGQMMSPSQQQMPMGYPPPYS", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more YTH_domain, YTH_domain, YTH_domain that are essential for its biological function; 2. The protein should belong to YTH_prot that shares evolutionary origin and functional similarity; 3. The protein should be classified within RBD_domain_sf, Nucleotide-bd_a/b_plait_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MSQSQVPSRAGHYNMTALANALPQANYRQAPWNNGSQMRYNPAGASPNVVGQTQSSPQYNGQPGMGSMPNQGYYMPQQQQQQQQMPQYYGGPMSPSQPQPNMSSRPNVPFYGNQVMSNHQAHPSMGYYYAQVPAYALQGHPPHQAPVDSQSNVVRGPPRKPRQSGHAIWIGNLPSQTDLMSLVHHVCREAQGLESLFLISKSNCAFANFRDEASCLTAQQKLHESKFQSVRLVSRLRKNTVEGASGITAPTGPSATTPQQAVAPEVKEIEQIDSTETQSDNADTDTPTAVGTPDAKGPAVVDAAQKDRFFVLKSLTVEDLDLSVRTGIWATQSHNEEALNSAFKNAENVYLVFSANKSGEYFGYARMVSTINEDPAAAIEFAPKAQSVNEVDLPREIPTEPTKFTPKGRIIDDSARGTIFWEIAREDSSEGVTQEEPAPAVAEQDDTTGGLDGNSENKTWGKPFKLEWLSTTRLPFYRCRGLRNPWNSNREVKIARDGTELEPSVGRRLIGLFNRSHNSPGPRGPMMGMGQMMSPSQQQMPMGYPPPYS" }, { "InterPro": [ { "InterPro-ID": "IPR002052", "InterPro-Name": "DNA_methylase_N6_adenine_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 155, "End": 161 }, { "InterPro-ID": "IPR007757", "InterPro-Name": "MT-A70-like", "InterPro-Type": "FAMILY", "Beg": 152, "End": 323 }, { "InterPro-ID": "IPR007757", "InterPro-Name": "MT-A70-like", "InterPro-Type": "FAMILY", "Beg": 111, "End": 336 }, { "InterPro-ID": "IPR029063", "InterPro-Name": "SAM-dependent_MTases_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 152, "End": 268 } ], "response#1": "MNGREHRRGDEAARREARSILFQNQDRSIVLIDVPTSIEEAQASPEEVGCDAGPLRKRRRLISSEPPHLPFKTPEPKAGSGGLTESVSDLMIAAAATEALRVLQESYAGPFCLPRVTRPNPLKSAFVPKGSFFLHGTVSSERDRFAAEAPVFDLIVLDPPWPNRSARRKQRNYRVADSLGSIRETLSLIPIAAHLAPDGLLAVWITNKAGVVELLTGPRGLFAQWGLEQVDEWTWLKITTSGEPIVDVGSTWRKPWERILIARRRGSSRKPACRGRVLVSVPDLHSRKPNLRGLFEDVLVPSNKGLEIFARNLTAGWWSWGDEVLKFQQPEYWVES", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to MT-A70-like, MT-A70-like that shares evolutionary origin and functional similarity; 2. The protein should be classified within SAM-dependent_MTases_sf sharing conserved structural features; 3. The protein should contain DNA_methylase_N6_adenine_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MNGREHRRGDEAARREARSILFQNQDRSIVLIDVPTSIEEAQASPEEVGCDAGPLRKRRRLISSEPPHLPFKTPEPKAGSGGLTESVSDLMIAAAATEALRVLQESYAGPFCLPRVTRPNPLKSAFVPKGSFFLHGTVSSERDRFAAEAPVFDLIVLDPPWPNRSARRKQRNYRVADSLGSIRETLSLIPIAAHLAPDGLLAVWITNKAGVVELLTGPRGLFAQWGLEQVDEWTWLKITTSGEPIVDVGSTWRKPWERILIARRRGSSRKPACRGRVLVSVPDLHSRKPNLRGLFEDVLVPSNKGLEIFARNLTAGWWSWGDEVLKFQQPEYWVES" }, { "InterPro": [ { "InterPro-ID": "IPR029052", "InterPro-Name": "Metallo-depent_PP-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 181, "End": 479 }, { "InterPro-ID": "IPR039331", "InterPro-Name": "PPA-like", "InterPro-Type": "FAMILY", "Beg": 32, "End": 491 }, { "InterPro-ID": "IPR008963", "InterPro-Name": "Purple_acid_Pase-like_N", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 14, "End": 121 }, { "InterPro-ID": "IPR029052", "InterPro-Name": "Metallo-depent_PP-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 164, "End": 503 }, { "InterPro-ID": "IPR025733", "InterPro-Name": "Purple_acid_PPase_C_dom", "InterPro-Type": "DOMAIN", "Beg": 429, "End": 490 }, { "InterPro-ID": "IPR041792", "InterPro-Name": "MPP_PAP", "InterPro-Type": "DOMAIN", "Beg": 168, "End": 495 }, { "InterPro-ID": "IPR015914", "InterPro-Name": "Purple_acid_Pase_N", "InterPro-Type": "DOMAIN", "Beg": 34, "End": 118 }, { "InterPro-ID": "IPR004843", "InterPro-Name": "Calcineurin-like_PHP_ApaH", "InterPro-Type": "DOMAIN", "Beg": 181, "End": 407 } ], "response#1": "MYTLLDILKGLPLLAVAAIASADYPTIPSDLTTPVQQRLAISGMNSVSVGWNTYEKLLKPCVQYGTSSTDLSQETCSLISTTYNTSRTWSNTVILTDLTPATTYYYQIVSTNSTVNSFFSPRTPGDKSPFTTSVVIDLGVYGADGFTVDADGDPTRKVLIPEVEPALNHTTIGRLADTWDDYEWVLHPGDFGYADDWYLTPTNVGDGVNAYEAILENFYDQLAPIAGGKVYMASPGNHEADCEELGTPAIELSCPEGQKNFTDFNVRFGKNMPTSFSSTSSNTKAKVNANKAAALANPPFWYSFEYGMVHVTMIDTETDFPNAPDAPFGTAGLDGGPFGYTGQQLDFFEADLASVDRTVTPWLLVAGHRPWYSTGGQSNICSACKTAFEPLMYQYGVDLGVFGHVHNSQRFAPVNNSVVDPAGMDNPTAPMYIIAGGAGNIEGLSSVGNNISSNRFAYAETFSYATLTFEDENNLSIQFIESATGDILDSSTLYKAHTEQFVNQ", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Purple_acid_PPase_C_dom, MPP_PAP, Purple_acid_Pase_N, Calcineurin-like_PHP_ApaH that are essential for its biological function; 2. The protein should belong to PPA-like that shares evolutionary origin and functional similarity; 3. The protein should be classified within Metallo-depent_PP-like, Purple_acid_Pase-like_N, Metallo-depent_PP-like sharing conserved structural features. The designed protein sequence is ", "reference": "MYTLLDILKGLPLLAVAAIASADYPTIPSDLTTPVQQRLAISGMNSVSVGWNTYEKLLKPCVQYGTSSTDLSQETCSLISTTYNTSRTWSNTVILTDLTPATTYYYQIVSTNSTVNSFFSPRTPGDKSPFTTSVVIDLGVYGADGFTVDADGDPTRKVLIPEVEPALNHTTIGRLADTWDDYEWVLHPGDFGYADDWYLTPTNVGDGVNAYEAILENFYDQLAPIAGGKVYMASPGNHEADCEELGTPAIELSCPEGQKNFTDFNVRFGKNMPTSFSSTSSNTKAKVNANKAAALANPPFWYSFEYGMVHVTMIDTETDFPNAPDAPFGTAGLDGGPFGYTGQQLDFFEADLASVDRTVTPWLLVAGHRPWYSTGGQSNICSACKTAFEPLMYQYGVDLGVFGHVHNSQRFAPVNNSVVDPAGMDNPTAPMYIIAGGAGNIEGLSSVGNNISSNRFAYAETFSYATLTFEDENNLSIQFIESATGDILDSSTLYKAHTEQFVNQ" }, { "InterPro": [ { "InterPro-ID": "IPR022596", "InterPro-Name": "GPR1_C", "InterPro-Type": "DOMAIN", "Beg": 283, "End": 352 }, { "InterPro-ID": "IPR022343", "InterPro-Name": "GCR1-cAMP_receptor", "InterPro-Type": "FAMILY", "Beg": 85, "End": 103 }, { "InterPro-ID": "IPR022343", "InterPro-Name": "GCR1-cAMP_receptor", "InterPro-Type": "FAMILY", "Beg": 43, "End": 58 }, { "InterPro-ID": "IPR022343", "InterPro-Name": "GCR1-cAMP_receptor", "InterPro-Type": "FAMILY", "Beg": 24, "End": 42 }, { "InterPro-ID": "IPR022340", "InterPro-Name": "GPCR_GCR1_put", "InterPro-Type": "FAMILY", "Beg": 46, "End": 68 }, { "InterPro-ID": "IPR022340", "InterPro-Name": "GPCR_GCR1_put", "InterPro-Type": "FAMILY", "Beg": 30, "End": 44 }, { "InterPro-ID": "IPR022340", "InterPro-Name": "GPCR_GCR1_put", "InterPro-Type": "FAMILY", "Beg": 176, "End": 199 }, { "InterPro-ID": "IPR022340", "InterPro-Name": "GPCR_GCR1_put", "InterPro-Type": "FAMILY", "Beg": 13, "End": 28 }, { "InterPro-ID": "IPR017981", "InterPro-Name": "GPCR_2-like_7TM", "InterPro-Type": "DOMAIN", "Beg": 13, "End": 198 }, { "InterPro-ID": "IPR023041", "InterPro-Name": "Glucose_rcpt_Git3_N", "InterPro-Type": "DOMAIN", "Beg": 15, "End": 194 }, { "InterPro-ID": "IPR017452", "InterPro-Name": "GPCR_Rhodpsn_7TM", "InterPro-Type": "DOMAIN", "Beg": 27, "End": 347 } ], "response#1": "MQPFGDAWSQRHLAGVVLAGSVLSIVGSLYMILGFFFLRECRSFRHKLILGLAVSDLLLALNFFIPSLSMVTGREISSPWNEGFCSANGFLMQLFFAQIDVWQISIALITLLMLSGPSMVLKWIRENVWAVWLFPWLVSLIAAFFAFGFWDYANVGGFCWLGSRNIRLYFNYIPRWIIILVCLVIYIAVYRLILHARRRANIQKTYRGRASDRAPPQPVTTTAPATNPESEKVNPDEISSGNGSSSLDTSRSGSSTGFTQTVHDPAVAGQIQTAAERAQEEAEQQKQVRKIAIQMISYPLAYAVLWAIPTIVMIIQVARGGEGVSIHVEGLAKMLLVFNGFVDAHVYGFNERTAMGWRQRIRPAAQEDDEEAAGTSGGVHEVVSRPEPTLKNPNVWQQNMV", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more GPR1_C, GPCR_2-like_7TM, Glucose_rcpt_Git3_N, GPCR_Rhodpsn_7TM that are essential for its biological function; 2. The protein should belong to GCR1-cAMP_receptor, GCR1-cAMP_receptor, GCR1-cAMP_receptor, GPCR_GCR1_put, GPCR_GCR1_put, GPCR_GCR1_put, GPCR_GCR1_put that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MQPFGDAWSQRHLAGVVLAGSVLSIVGSLYMILGFFFLRECRSFRHKLILGLAVSDLLLALNFFIPSLSMVTGREISSPWNEGFCSANGFLMQLFFAQIDVWQISIALITLLMLSGPSMVLKWIRENVWAVWLFPWLVSLIAAFFAFGFWDYANVGGFCWLGSRNIRLYFNYIPRWIIILVCLVIYIAVYRLILHARRRANIQKTYRGRASDRAPPQPVTTTAPATNPESEKVNPDEISSGNGSSSLDTSRSGSSTGFTQTVHDPAVAGQIQTAAERAQEEAEQQKQVRKIAIQMISYPLAYAVLWAIPTIVMIIQVARGGEGVSIHVEGLAKMLLVFNGFVDAHVYGFNERTAMGWRQRIRPAAQEDDEEAAGTSGGVHEVVSRPEPTLKNPNVWQQNMV" }, { "InterPro": [ { "InterPro-ID": "IPR023213", "InterPro-Name": "CAT-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1846, "End": 1977 }, { "InterPro-ID": "IPR023213", "InterPro-Name": "CAT-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 3126, "End": 3309 }, { "InterPro-ID": "IPR009081", "InterPro-Name": "PP-bd_ACP", "InterPro-Type": "DOMAIN", "Beg": 4114, "End": 4190 }, { "InterPro-ID": "IPR042099", "InterPro-Name": "ANL_N_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 2183, "End": 2511 }, { "InterPro-ID": "IPR042099", "InterPro-Name": "ANL_N_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1288, "End": 1622 }, { "InterPro-ID": "IPR042099", "InterPro-Name": "ANL_N_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 227, "End": 628 }, { "InterPro-ID": "IPR036736", "InterPro-Name": "ACP-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 2635, "End": 2674 }, { "InterPro-ID": "IPR010071", "InterPro-Name": "AA_adenyl_dom", "InterPro-Type": "DOMAIN", "Beg": 3604, "End": 3995 }, { "InterPro-ID": "IPR036736", "InterPro-Name": "ACP-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 772, "End": 846 }, { "InterPro-ID": "IPR042099", "InterPro-Name": "ANL_N_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 3578, "End": 3980 }, { "InterPro-ID": "IPR045851", "InterPro-Name": "AMP-bd_C_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 2512, "End": 2613 }, { "InterPro-ID": "IPR020806", "InterPro-Name": "PKS_PP-bd", "InterPro-Type": "DOMAIN", "Beg": 779, "End": 849 }, { "InterPro-ID": "IPR020806", "InterPro-Name": "PKS_PP-bd", "InterPro-Type": "DOMAIN", "Beg": 2636, "End": 2700 }, { "InterPro-ID": "IPR020806", "InterPro-Name": "PKS_PP-bd", "InterPro-Type": "DOMAIN", "Beg": 4120, "End": 4190 }, { "InterPro-ID": "IPR036736", "InterPro-Name": "ACP-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 2623, "End": 2685 }, { "InterPro-ID": "IPR036736", "InterPro-Name": "ACP-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 772, "End": 844 }, { "InterPro-ID": "IPR036736", "InterPro-Name": "ACP-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1745, "End": 1818 }, { "InterPro-ID": "IPR036736", "InterPro-Name": "ACP-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 4112, "End": 4186 }, { "InterPro-ID": "IPR009081", "InterPro-Name": "PP-bd_ACP", "InterPro-Type": "DOMAIN", "Beg": 773, "End": 849 }, { "InterPro-ID": "IPR006162", "InterPro-Name": "Ppantetheine_attach_site", "InterPro-Type": "PTM", "Beg": 4146, "End": 4161 }, { "InterPro-ID": "IPR000873", "InterPro-Name": "AMP-dep_synth/lig_dom", "InterPro-Type": "DOMAIN", "Beg": 1290, "End": 1595 }, { "InterPro-ID": "IPR000873", "InterPro-Name": "AMP-dep_synth/lig_dom", "InterPro-Type": "DOMAIN", "Beg": 3589, "End": 3924 }, { "InterPro-ID": "IPR000873", "InterPro-Name": "AMP-dep_synth/lig_dom", "InterPro-Type": "DOMAIN", "Beg": 2290, "End": 2361 }, { "InterPro-ID": "IPR000873", "InterPro-Name": "AMP-dep_synth/lig_dom", "InterPro-Type": "DOMAIN", "Beg": 235, "End": 576 }, { "InterPro-ID": "IPR009081", "InterPro-Name": "PP-bd_ACP", "InterPro-Type": "DOMAIN", "Beg": 1745, "End": 1822 }, { "InterPro-ID": "IPR006162", "InterPro-Name": "Ppantetheine_attach_site", "InterPro-Type": "PTM", "Beg": 1777, "End": 1792 }, { "InterPro-ID": "IPR045851", "InterPro-Name": "AMP-bd_C_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 3981, "End": 4103 }, { "InterPro-ID": "IPR045851", "InterPro-Name": "AMP-bd_C_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 630, "End": 761 }, { "InterPro-ID": "IPR023213", "InterPro-Name": "CAT-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 2692, "End": 2846 }, { "InterPro-ID": "IPR023213", "InterPro-Name": "CAT-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 879, "End": 1043 }, { "InterPro-ID": "IPR001242", "InterPro-Name": "Condensatn", "InterPro-Type": "DOMAIN", "Beg": 890, "End": 1212 }, { "InterPro-ID": "IPR001242", "InterPro-Name": "Condensatn", "InterPro-Type": "DOMAIN", "Beg": 3128, "End": 3565 }, { "InterPro-ID": "IPR001242", "InterPro-Name": "Condensatn", "InterPro-Type": "DOMAIN", "Beg": 4249, "End": 4648 }, { "InterPro-ID": "IPR001242", "InterPro-Name": "Condensatn", "InterPro-Type": "DOMAIN", "Beg": 2722, "End": 2998 }, { "InterPro-ID": "IPR020845", "InterPro-Name": "AMP-binding_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 377, "End": 388 }, { "InterPro-ID": "IPR009081", "InterPro-Name": "PP-bd_ACP", "InterPro-Type": "DOMAIN", "Beg": 781, "End": 845 }, { "InterPro-ID": "IPR009081", "InterPro-Name": "PP-bd_ACP", "InterPro-Type": "DOMAIN", "Beg": 1756, "End": 1817 }, { "InterPro-ID": "IPR009081", "InterPro-Name": "PP-bd_ACP", "InterPro-Type": "DOMAIN", "Beg": 4122, "End": 4185 }, { "InterPro-ID": "IPR009081", "InterPro-Name": "PP-bd_ACP", "InterPro-Type": "DOMAIN", "Beg": 2638, "End": 2672 }, { "InterPro-ID": "IPR006162", "InterPro-Name": "Ppantetheine_attach_site", "InterPro-Type": "PTM", "Beg": 805, "End": 820 }, { "InterPro-ID": "IPR020845", "InterPro-Name": "AMP-binding_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 1417, "End": 1428 }, { "InterPro-ID": "IPR023213", "InterPro-Name": "CAT-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 4226, "End": 4395 }, { "InterPro-ID": "IPR045851", "InterPro-Name": "AMP-bd_C_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1623, "End": 1717 }, { "InterPro-ID": "IPR036736", "InterPro-Name": "ACP-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1745, "End": 1816 }, { "InterPro-ID": "IPR036736", "InterPro-Name": "ACP-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 4114, "End": 4187 } ], "response#1": "MDTMKRKHQGLFPVLNDGGREPSVTVNEISSEARERAIAYTARRGYDIVHFLRTVWSIVLQQFLETDLVCFVFFDHSGVQVCEVPVSREESIPNLLERIAELRPLPSALCEETRMNTGLLIGDTSLDVNPTAVLDTFRRIQKDNQPCDCLLVLEGEPPHRLALVATTTLLSSDQATAVASTVSQVMVEMSAEDNSRTVGDLSLLSEHDQQCLVRWNNFQAPPTNTDGSILDTIRAKALSQPEATAIHSPDVIMTYHELDTISNKLAVHLRLLGVRPDILVPFLFQRCHWVIVVQLAVLKAGGAFVPLEPAHPNARLAEITKRTNCGFLLTSDANAGRAALLAEKVVCINHSLMSSLPTDFTTYRLVPLSSPSSPAYVLFTSGSTGQPKGCVVDCRAMAQIPNQAVVQSMGLSSSTRVLQFASYTFAISIFEIYYALGSGATICMPTDHDRINSLATVMDEMKITWACMTPSLLRTLDPERSPATLKRVFLGGEPVVKGEFEAWAAIVDLVYVYGASEVSGAIGFTDHQCDGNDIAYRAFPGMRFWISDALDYHKLAPVGVTGELILEGPALAQRYLDDVQSTLTAFIDPPLWRQSLGLPTVGAASRMYKTGDLFRYAHDGSVIHVGRKGTQVKIRGKRLDLGEVEFHVSKCCPNVARVIAETAAPLDANGVPALVLFLYYSADDAGERNEETTPQTLFAAASERFQSIVQSTQTKLEQTLPDHMLPSFYLPLASIPMTVTGKVDRRALRESVQKCTRRELEAYQPTGVVELVPPETVLEKALHAVFAQVLRIDGATFGVHHSFIRLGGDSLAAMRAVGLLTTKEYNVTVADILGQPTVSKLAQYLRNTERPQRASAAASAPPPFSLLAGGHDETVASAAQQCGMSISAIEDCYPCTALQQGLMISTMRVPGRYIARCVFDLARGLDLERLKAAWQQTVDANVILRTRIVRRASGDLIQAVLGRQVSAIQWQSYPTVGAYKMEDAVIPMQPGDALARFALIGDTFSGWSLGLTLHHAIFDAHSLGLLLEQTQQAYYGANLDPNLFSPFIETVQKQDGASEREFWTATFADIHAPVFPSLPHDRAVPRASTHLERTIPLLSRTGSGITLSNVARLAWAIVVSAHTDSEDVVFGVTVNGRATATAGAQDMTGPTIATVPFPVRCQKQKKVADVLEAVQSLAISMMAFEQTGLQKIRQMSPQAAAACDFQSQLIFQRPAALDPSHQHDAPPIMVGKTALHGLEDFSVFIDYVIGAYFDGDILPGYMAERMMGQFANVLQQLCAGQHDRVVGELELNAQKEPLMPAVSSWDRGLTYRELDVLSATIAQTIIMPAGVKERDRVALCFEKSVWPVLSMLAVLRAGATAVNIDPTLPPARMSAILETGLPVIEISQTSVPMTTTTTEEAAQIQWPTVQPNDVAFILFTSGSTGTPKGIVIEHRHFTTAFHHHRDALLQEIFFTWVHGGCLCIPSEEQRLSNLAGFIREHQVNWAIMTPSASTILRPQSVPGLETLVLAGEPIPVELMELWSSRLRLLNGYGPAEAFTCAFNRIEPGSHHPGLFGPMCGVVGWVTVPDNADRLAALGAVGELLIEGPTVTRGYLDLPELSGEAFIDAPEWLRKIRPGYLGRKDTQVKQVVAEVVQPQGSAAVMLVAFVYTAPVQGHEEKTQLLLREPDENFLQACAAAVARLEGVLPAHMIPTAMCPLYRVPYGATSKIDRRQLRQAAERLTPEQLQAYTTGVADNCKNVSKEPPVSAAEKKWQALWARVLGVPTQRIGRDDLFFRLGGDSLSVIRLLDLAGQEGLPHLTFQDVLQNPRLREIAALSETRDSSRGSDDNDDGPAPFALVKDADALLRVATNLIAATVHQRGAYQAWAVTAKCNPILRTRIFQTPDGSSYQAVLNSPLNWSRHETLDDVFASQPVMGLGTPLAHLMLSPGHLHLVIHHALYDGWSLSLLVAEVDKAYLGLPLPPAAKFNNFIAHVESSMQIIDLPDNPTQSNVTVASKIKLAWALVSRAYTNNSDTVTGFVSSGRTAPVAGIVKVPGPTIASVPLRIRLSATQRYEHLGLQNISQQSEGGAAACQFQTLIAVEAKEHEVQGAGERHTWFCGEKTRPGGGAIEVTATFDPEVLASEQMHRVLAQLDHFLVQIQAVSEASATTIADLDILSDEDLQQLLRWNALPLPPTPWGCNRCVHDLVHDACQRRPAAVAIEAWDGQFTYQQIDDHVADLAHRIQTLGVVRPDTFVGLYIEKSRWTVVAQLAPLQRLRELCAITKLPLILTTEDQQEAVAGLFSLPTGCTRVKPSNAMYTIATSGTTGKPKVAVIEHGCFIANIQPIIDAVGINANSRVLQFAGYGFDAMLIEHMITLLVITEMGANWAMLTASVIQLLTPTNVPTLTTLVQAGEPMQQGIVDRWASHNCIPPGAAPYDIGYATGGVTWVVDPDTLDPVPIGAEGELIIEGDIVGRGYLNDLERTAAAFIPCPHWLADLRRSSNANGTEPGPGTQLHRVYRTGDLIKLRGQRLELTEVEHHVQQTFPGALQVVAAVSTLGAATDTDRTDILLPASNPDFHKAVETTELALVERVPAYMVPSIFIPLSRVPRDNNGKVDRRLINARLSSLSRKEADGYSPSSSAASTIVAPQNRLQHDIRAIWAGVLGMADEDIGIHNSFFRIGGDSITSMQHRTISQLALHATRKDDGEKRALPSEEEADVGLDHASVFLHLEGPGVGGAESMARALAVIVETHPMLRARFEKSSDGTWRQRVTGNADQSNYRYYHHGVTSQEQITSICSASQQALDIRHGPLLIIDQFERDDATTWLFLVAHHLVIDLVSWRVVLADLEQLLTTGERPKVPPTSFLRWCQLQADYAARLSAPHQVEEDQETDISAYWGKGVTRNTHRDVDRYALILDKQTSELLLTKANIALNTQPVEIVQAALLHSFVHLFPDRPAPIIFSEGHGREPWDATIDITRTVGWFTTICPAQVSLDASEDFVTALRRTKDARRRSPANGWEHFTARYLHPQGPKTMKGMEILFNYQGRYQQLERPDAMLKIDMANQFTAGDVAPDMQRFAPIEDRLYQWGPVCERSLRQAAAQLTGMSGHIQTVSDFPLGSSHVTSDLLDETLRTMRTRLANGRQLIVQDVYPCTPIQQGMLMGYTRTPWHYEQVLTWRVVGASLRDVARLQAAWQHVVNAHPALRTVFLQTSDGHIEQLVLQDYTPVVRIHQDSSHQSHAPEPEPVSLDALKPLHELHVHTSSTSGDVVLRLHINHALVDGTSTKILRRDLVCAYEGQPLPTMMLESQSYRDYVEYMLTQAASLKSHQYWQSHLQGALPCLVPSLQGHDGSNDLPQSVSTIRSFTMELGPTEALDTFCEVHELALTVLFHVAWALVVKQYTASEDVCFGYIASARHAPVQGIDDMVGPLINMLVGRIDMPAGMTLLSVLQQYNRTYLHSLEHQHQPLAEALNAIGSTSGELFNTLLTVQYQQDPRKDAAGDPSGIVLLDEDMEDKSEYPVTLNVAVFPDRVELLFSHHTAHMSDWYAARMARCFRHALAEVLTHPSLPVGEIQVVDDSQRQQILQRNEPLADPVNTCVHHIIHQRCLDFPASAAVCSWDGEFTYEELDTVSSALAEELIDYSIGVDMTIPVLLEKSRWVPVAVLGILKTGASFVLMDASHPEARLRGLCEDVQAPLILASRGTFSKASNLAPHVVCLGERLLGEIACPHPARWSRVPVCASNAAYTVFTSGSTGKPKGAILDHSCLATAAKHLQSCMYMNSASRVLQFSSHAWDIAVADIVLTLLAGGCVCIPSEEERTGDIAAAANRMRVNWAILTPTVSRLVKPGALKHLQTLVLAGEPLSPSDLAIWHDKVRLISAYGPAECCPISTVSEPLTASSNPRDIGRPPANVAWIVDRDNHARLVPEGVVGELLLEGPTVGRGYVNNAQQTAAAFIDPPLWLRGLRHGQSSTRLYKTGDLARFTPDGRLIFVGRKDNQIKIRGQRLELGEVEAQAGIAFLNRDVTVELVGQADDAFLVAFVHPMADDHESPAAGTGSLLRQPHSQQFQESVRAAISTLREALPSYMVPTAFLPLAWVPKSPTGKTDRKRLIELAASLSQSELDVYSGTNATRRTPSTPLEAQLQDLVARVLKRSPGSIALDEDLFHIGLDSLRAMTLASLAAKEGLKLLALTIFQHPRLSQLAAVLEEGARAAAVSSTTSSSPQSTPNPLLDSVDDLCTKWKIDRSQVADVLPTTFYQRGSLDCQHLAHMVLTFSQPVDVARLQSVVVAAIRHYDILRTVFVPFENTTVQLILHKMSLPTVEIQTDKDLQSTVQSICQQDIQTPIPPGHPVTRLFFVISRKQDDNHLAMILRLHHAQYDGVSIRRIHNYITAAYEEPTHPPLTTAGYADFLNARRHHQHASTFQFWRDLLHGSTMTCLASGGGHISTTTHRHRMDLLVTSAREIPRPRLQPGLTMATYLKAAWALVLAAQTHTHDLVFAQLVSGRNLPVPDIDRIVGPCINYIPVRVTLQPTWTCSELLRNVQAQHIRTMAHDAVDFDELVARSTAWPAGTEIGTGVHFLHGDRFWDEVRTVAGVECRSQHVDFKLLQTYPMLTCTGSPDAEEATGRSVLGVALTSAVFGQEVADRVFEVFLGMLDYLTTTPEKLVAEVI", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more PP-bd_ACP, AA_adenyl_dom, PKS_PP-bd, PKS_PP-bd, PKS_PP-bd, PP-bd_ACP, AMP-dep_synth/lig_dom, AMP-dep_synth/lig_dom, AMP-dep_synth/lig_dom, AMP-dep_synth/lig_dom, PP-bd_ACP, Condensatn, Condensatn, Condensatn, Condensatn, PP-bd_ACP, PP-bd_ACP, PP-bd_ACP, PP-bd_ACP that are essential for its biological function; 2. The protein should be classified within CAT-like_dom_sf, CAT-like_dom_sf, ANL_N_sf, ANL_N_sf, ANL_N_sf, ACP-like_sf, ACP-like_sf, ANL_N_sf, AMP-bd_C_sf, ACP-like_sf, ACP-like_sf, ACP-like_sf, ACP-like_sf, AMP-bd_C_sf, AMP-bd_C_sf, CAT-like_dom_sf, CAT-like_dom_sf, CAT-like_dom_sf, AMP-bd_C_sf, ACP-like_sf, ACP-like_sf sharing conserved structural features; 3. The protein should contain AMP-binding_CS, AMP-binding_CS that is preserved across related proteins; 4. The protein should contain Ppantetheine_attach_site, Ppantetheine_attach_site, Ppantetheine_attach_site that allow regulation through chemical modifications. The designed protein sequence is ", "reference": "MDTMKRKHQGLFPVLNDGGREPSVTVNEISSEARERAIAYTARRGYDIVHFLRTVWSIVLQQFLETDLVCFVFFDHSGVQVCEVPVSREESIPNLLERIAELRPLPSALCEETRMNTGLLIGDTSLDVNPTAVLDTFRRIQKDNQPCDCLLVLEGEPPHRLALVATTTLLSSDQATAVASTVSQVMVEMSAEDNSRTVGDLSLLSEHDQQCLVRWNNFQAPPTNTDGSILDTIRAKALSQPEATAIHSPDVIMTYHELDTISNKLAVHLRLLGVRPDILVPFLFQRCHWVIVVQLAVLKAGGAFVPLEPAHPNARLAEITKRTNCGFLLTSDANAGRAALLAEKVVCINHSLMSSLPTDFTTYRLVPLSSPSSPAYVLFTSGSTGQPKGCVVDCRAMAQIPNQAVVQSMGLSSSTRVLQFASYTFAISIFEIYYALGSGATICMPTDHDRINSLATVMDEMKITWACMTPSLLRTLDPERSPATLKRVFLGGEPVVKGEFEAWAAIVDLVYVYGASEVSGAIGFTDHQCDGNDIAYRAFPGMRFWISDALDYHKLAPVGVTGELILEGPALAQRYLDDVQSTLTAFIDPPLWRQSLGLPTVGAASRMYKTGDLFRYAHDGSVIHVGRKGTQVKIRGKRLDLGEVEFHVSKCCPNVARVIAETAAPLDANGVPALVLFLYYSADDAGERNEETTPQTLFAAASERFQSIVQSTQTKLEQTLPDHMLPSFYLPLASIPMTVTGKVDRRALRESVQKCTRRELEAYQPTGVVELVPPETVLEKALHAVFAQVLRIDGATFGVHHSFIRLGGDSLAAMRAVGLLTTKEYNVTVADILGQPTVSKLAQYLRNTERPQRASAAASAPPPFSLLAGGHDETVASAAQQCGMSISAIEDCYPCTALQQGLMISTMRVPGRYIARCVFDLARGLDLERLKAAWQQTVDANVILRTRIVRRASGDLIQAVLGRQVSAIQWQSYPTVGAYKMEDAVIPMQPGDALARFALIGDTFSGWSLGLTLHHAIFDAHSLGLLLEQTQQAYYGANLDPNLFSPFIETVQKQDGASEREFWTATFADIHAPVFPSLPHDRAVPRASTHLERTIPLLSRTGSGITLSNVARLAWAIVVSAHTDSEDVVFGVTVNGRATATAGAQDMTGPTIATVPFPVRCQKQKKVADVLEAVQSLAISMMAFEQTGLQKIRQMSPQAAAACDFQSQLIFQRPAALDPSHQHDAPPIMVGKTALHGLEDFSVFIDYVIGAYFDGDILPGYMAERMMGQFANVLQQLCAGQHDRVVGELELNAQKEPLMPAVSSWDRGLTYRELDVLSATIAQTIIMPAGVKERDRVALCFEKSVWPVLSMLAVLRAGATAVNIDPTLPPARMSAILETGLPVIEISQTSVPMTTTTTEEAAQIQWPTVQPNDVAFILFTSGSTGTPKGIVIEHRHFTTAFHHHRDALLQEIFFTWVHGGCLCIPSEEQRLSNLAGFIREHQVNWAIMTPSASTILRPQSVPGLETLVLAGEPIPVELMELWSSRLRLLNGYGPAEAFTCAFNRIEPGSHHPGLFGPMCGVVGWVTVPDNADRLAALGAVGELLIEGPTVTRGYLDLPELSGEAFIDAPEWLRKIRPGYLGRKDTQVKQVVAEVVQPQGSAAVMLVAFVYTAPVQGHEEKTQLLLREPDENFLQACAAAVARLEGVLPAHMIPTAMCPLYRVPYGATSKIDRRQLRQAAERLTPEQLQAYTTGVADNCKNVSKEPPVSAAEKKWQALWARVLGVPTQRIGRDDLFFRLGGDSLSVIRLLDLAGQEGLPHLTFQDVLQNPRLREIAALSETRDSSRGSDDNDDGPAPFALVKDADALLRVATNLIAATVHQRGAYQAWAVTAKCNPILRTRIFQTPDGSSYQAVLNSPLNWSRHETLDDVFASQPVMGLGTPLAHLMLSPGHLHLVIHHALYDGWSLSLLVAEVDKAYLGLPLPPAAKFNNFIAHVESSMQIIDLPDNPTQSNVTVASKIKLAWALVSRAYTNNSDTVTGFVSSGRTAPVAGIVKVPGPTIASVPLRIRLSATQRYEHLGLQNISQQSEGGAAACQFQTLIAVEAKEHEVQGAGERHTWFCGEKTRPGGGAIEVTATFDPEVLASEQMHRVLAQLDHFLVQIQAVSEASATTIADLDILSDEDLQQLLRWNALPLPPTPWGCNRCVHDLVHDACQRRPAAVAIEAWDGQFTYQQIDDHVADLAHRIQTLGVVRPDTFVGLYIEKSRWTVVAQLAPLQRLRELCAITKLPLILTTEDQQEAVAGLFSLPTGCTRVKPSNAMYTIATSGTTGKPKVAVIEHGCFIANIQPIIDAVGINANSRVLQFAGYGFDAMLIEHMITLLVITEMGANWAMLTASVIQLLTPTNVPTLTTLVQAGEPMQQGIVDRWASHNCIPPGAAPYDIGYATGGVTWVVDPDTLDPVPIGAEGELIIEGDIVGRGYLNDLERTAAAFIPCPHWLADLRRSSNANGTEPGPGTQLHRVYRTGDLIKLRGQRLELTEVEHHVQQTFPGALQVVAAVSTLGAATDTDRTDILLPASNPDFHKAVETTELALVERVPAYMVPSIFIPLSRVPRDNNGKVDRRLINARLSSLSRKEADGYSPSSSAASTIVAPQNRLQHDIRAIWAGVLGMADEDIGIHNSFFRIGGDSITSMQHRTISQLALHATRKDDGEKRALPSEEEADVGLDHASVFLHLEGPGVGGAESMARALAVIVETHPMLRARFEKSSDGTWRQRVTGNADQSNYRYYHHGVTSQEQITSICSASQQALDIRHGPLLIIDQFERDDATTWLFLVAHHLVIDLVSWRVVLADLEQLLTTGERPKVPPTSFLRWCQLQADYAARLSAPHQVEEDQETDISAYWGKGVTRNTHRDVDRYALILDKQTSELLLTKANIALNTQPVEIVQAALLHSFVHLFPDRPAPIIFSEGHGREPWDATIDITRTVGWFTTICPAQVSLDASEDFVTALRRTKDARRRSPANGWEHFTARYLHPQGPKTMKGMEILFNYQGRYQQLERPDAMLKIDMANQFTAGDVAPDMQRFAPIEDRLYQWGPVCERSLRQAAAQLTGMSGHIQTVSDFPLGSSHVTSDLLDETLRTMRTRLANGRQLIVQDVYPCTPIQQGMLMGYTRTPWHYEQVLTWRVVGASLRDVARLQAAWQHVVNAHPALRTVFLQTSDGHIEQLVLQDYTPVVRIHQDSSHQSHAPEPEPVSLDALKPLHELHVHTSSTSGDVVLRLHINHALVDGTSTKILRRDLVCAYEGQPLPTMMLESQSYRDYVEYMLTQAASLKSHQYWQSHLQGALPCLVPSLQGHDGSNDLPQSVSTIRSFTMELGPTEALDTFCEVHELALTVLFHVAWALVVKQYTASEDVCFGYIASARHAPVQGIDDMVGPLINMLVGRIDMPAGMTLLSVLQQYNRTYLHSLEHQHQPLAEALNAIGSTSGELFNTLLTVQYQQDPRKDAAGDPSGIVLLDEDMEDKSEYPVTLNVAVFPDRVELLFSHHTAHMSDWYAARMARCFRHALAEVLTHPSLPVGEIQVVDDSQRQQILQRNEPLADPVNTCVHHIIHQRCLDFPASAAVCSWDGEFTYEELDTVSSALAEELIDYSIGVDMTIPVLLEKSRWVPVAVLGILKTGASFVLMDASHPEARLRGLCEDVQAPLILASRGTFSKASNLAPHVVCLGERLLGEIACPHPARWSRVPVCASNAAYTVFTSGSTGKPKGAILDHSCLATAAKHLQSCMYMNSASRVLQFSSHAWDIAVADIVLTLLAGGCVCIPSEEERTGDIAAAANRMRVNWAILTPTVSRLVKPGALKHLQTLVLAGEPLSPSDLAIWHDKVRLISAYGPAECCPISTVSEPLTASSNPRDIGRPPANVAWIVDRDNHARLVPEGVVGELLLEGPTVGRGYVNNAQQTAAAFIDPPLWLRGLRHGQSSTRLYKTGDLARFTPDGRLIFVGRKDNQIKIRGQRLELGEVEAQAGIAFLNRDVTVELVGQADDAFLVAFVHPMADDHESPAAGTGSLLRQPHSQQFQESVRAAISTLREALPSYMVPTAFLPLAWVPKSPTGKTDRKRLIELAASLSQSELDVYSGTNATRRTPSTPLEAQLQDLVARVLKRSPGSIALDEDLFHIGLDSLRAMTLASLAAKEGLKLLALTIFQHPRLSQLAAVLEEGARAAAVSSTTSSSPQSTPNPLLDSVDDLCTKWKIDRSQVADVLPTTFYQRGSLDCQHLAHMVLTFSQPVDVARLQSVVVAAIRHYDILRTVFVPFENTTVQLILHKMSLPTVEIQTDKDLQSTVQSICQQDIQTPIPPGHPVTRLFFVISRKQDDNHLAMILRLHHAQYDGVSIRRIHNYITAAYEEPTHPPLTTAGYADFLNARRHHQHASTFQFWRDLLHGSTMTCLASGGGHISTTTHRHRMDLLVTSAREIPRPRLQPGLTMATYLKAAWALVLAAQTHTHDLVFAQLVSGRNLPVPDIDRIVGPCINYIPVRVTLQPTWTCSELLRNVQAQHIRTMAHDAVDFDELVARSTAWPAGTEIGTGVHFLHGDRFWDEVRTVAGVECRSQHVDFKLLQTYPMLTCTGSPDAEEATGRSVLGVALTSAVFGQEVADRVFEVFLGMLDYLTTTPEKLVAEVI" }, { "InterPro": [ { "InterPro-ID": "IPR050131", "InterPro-Name": "Peptidase_S8_subtilisin-like", "InterPro-Type": "FAMILY", "Beg": 152, "End": 557 }, { "InterPro-ID": "IPR022398", "InterPro-Name": "Peptidase_S8_His-AS", "InterPro-Type": "ACTIVE_SITE", "Beg": 342, "End": 352 }, { "InterPro-ID": "IPR036852", "InterPro-Name": "Peptidase_S8/S53_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 256, "End": 577 }, { "InterPro-ID": "IPR041089", "InterPro-Name": "SUB1_ProdP9", "InterPro-Type": "DOMAIN", "Beg": 116, "End": 195 }, { "InterPro-ID": "IPR000209", "InterPro-Name": "Peptidase_S8/S53_dom", "InterPro-Type": "DOMAIN", "Beg": 280, "End": 557 }, { "InterPro-ID": "IPR023828", "InterPro-Name": "Peptidase_S8_Ser-AS", "InterPro-Type": "ACTIVE_SITE", "Beg": 517, "End": 527 }, { "InterPro-ID": "IPR036852", "InterPro-Name": "Peptidase_S8/S53_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 243, "End": 584 }, { "InterPro-ID": "IPR015500", "InterPro-Name": "Peptidase_S8_subtilisin-rel", "InterPro-Type": "FAMILY", "Beg": 516, "End": 532 }, { "InterPro-ID": "IPR015500", "InterPro-Name": "Peptidase_S8_subtilisin-rel", "InterPro-Type": "FAMILY", "Beg": 277, "End": 296 }, { "InterPro-ID": "IPR015500", "InterPro-Name": "Peptidase_S8_subtilisin-rel", "InterPro-Type": "FAMILY", "Beg": 338, "End": 351 }, { "InterPro-ID": "IPR023827", "InterPro-Name": "Peptidase_S8_Asp-AS", "InterPro-Type": "ACTIVE_SITE", "Beg": 282, "End": 293 } ], "response#1": "MRTVFIYACIISLVLRTIPAHNDLMSKEKENKEKDVHKIIEDLRFLEKVDAILENSNMTIDDVKADADAYNPDEDAPKEELNKIEMEKKKAEEEAKNSKKKILERYLLDEKKKKSLRLIVSENHATSPSFFEESLIQEDFMSFIQSKGEIVNLKNLKSMIIELNSDMTDKELEAYITLLKKKGAHVESDELVGADSIYVDIIKDAVKRGDTSINFKKMQSNMLEVENKTYEKLNNNLKKSKNSYKKSFFNDEYRNLQWGLDLARLDDAQEMITTNSVETTKICVIDSGIDYNHPDLKGNIYVNLNELNGKEGIDDDNNGIIDDIYGVNYVNNTGDPWDDHNHGSHVSGIISAIGNNSIGVVGVNPSSKLVICKALDDKKLGRLGNIFKCIDYCINKKVNIINGSFSFDEYSTIFSSTIEYLARLGILFVVSSSNCSHPPSSIPDITRCDLSVNSKYPSVLSTQYDNMVVVANLKKKINGEYDISINSFYSDIYCQVSAPGANIYSTASRGSYMELSGTSMAAPHVAGIASIILSINPDLTYKQVVNILKNSVVKLSSHKNKIAWGGYIDILNAVKNAISSKNSYIRFQGIRMWKSKKRN", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more SUB1_ProdP9, Peptidase_S8/S53_dom that are essential for its biological function; 2. The protein should belong to Peptidase_S8_subtilisin-like, Peptidase_S8_subtilisin-rel, Peptidase_S8_subtilisin-rel, Peptidase_S8_subtilisin-rel that shares evolutionary origin and functional similarity; 3. The protein should be classified within Peptidase_S8/S53_dom_sf, Peptidase_S8/S53_dom_sf sharing conserved structural features; 4. The protein must have Peptidase_S8_His-AS, Peptidase_S8_Ser-AS, Peptidase_S8_Asp-AS that is conserved among related catalytic enzymes. The designed protein sequence is ", "reference": "MRTVFIYACIISLVLRTIPAHNDLMSKEKENKEKDVHKIIEDLRFLEKVDAILENSNMTIDDVKADADAYNPDEDAPKEELNKIEMEKKKAEEEAKNSKKKILERYLLDEKKKKSLRLIVSENHATSPSFFEESLIQEDFMSFIQSKGEIVNLKNLKSMIIELNSDMTDKELEAYITLLKKKGAHVESDELVGADSIYVDIIKDAVKRGDTSINFKKMQSNMLEVENKTYEKLNNNLKKSKNSYKKSFFNDEYRNLQWGLDLARLDDAQEMITTNSVETTKICVIDSGIDYNHPDLKGNIYVNLNELNGKEGIDDDNNGIIDDIYGVNYVNNTGDPWDDHNHGSHVSGIISAIGNNSIGVVGVNPSSKLVICKALDDKKLGRLGNIFKCIDYCINKKVNIINGSFSFDEYSTIFSSTIEYLARLGILFVVSSSNCSHPPSSIPDITRCDLSVNSKYPSVLSTQYDNMVVVANLKKKINGEYDISINSFYSDIYCQVSAPGANIYSTASRGSYMELSGTSMAAPHVAGIASIILSINPDLTYKQVVNILKNSVVKLSSHKNKIAWGGYIDILNAVKNAISSKNSYIRFQGIRMWKSKKRN" }, { "InterPro": [ { "InterPro-ID": "IPR003382", "InterPro-Name": "Flavoprotein", "InterPro-Type": "DOMAIN", "Beg": 23, "End": 195 }, { "InterPro-ID": "IPR036551", "InterPro-Name": "Flavin_trans-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 21, "End": 199 }, { "InterPro-ID": "IPR036551", "InterPro-Name": "Flavin_trans-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 21, "End": 210 } ], "response#1": "MTSSEPASPEIEQQANSAPRRPRILLAASGSVAAIKFGNLCHSFSEWAEVKAVATRASLHFIDRASLPKDVILYTEEDEWSTWNKVGDSVLHIELRSWADILVIAPLSANTLGKIAGGLCDNLLTCIVRAWDYSKPFFVAPAMNTLMWKNPFTEQHIMSIDELGVSLIPPVTKRLACGDYGNGAMAEPSVIYSTVRLFFESRVQQSGNIVQQPV", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Flavoprotein that are essential for its biological function; 2. The protein should be classified within Flavin_trans-like, Flavin_trans-like sharing conserved structural features. The designed protein sequence is ", "reference": "MTSSEPASPEIEQQANSAPRRPRILLAASGSVAAIKFGNLCHSFSEWAEVKAVATRASLHFIDRASLPKDVILYTEEDEWSTWNKVGDSVLHIELRSWADILVIAPLSANTLGKIAGGLCDNLLTCIVRAWDYSKPFFVAPAMNTLMWKNPFTEQHIMSIDELGVSLIPPVTKRLACGDYGNGAMAEPSVIYSTVRLFFESRVQQSGNIVQQPV" }, { "InterPro": [ { "InterPro-ID": "IPR000277", "InterPro-Name": "Cys/Met-Metab_PyrdxlP-dep_enz", "InterPro-Type": "FAMILY", "Beg": 21, "End": 402 }, { "InterPro-ID": "IPR015422", "InterPro-Name": "PyrdxlP-dep_Trfase_small", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 270, "End": 401 }, { "InterPro-ID": "IPR015424", "InterPro-Name": "PyrdxlP-dep_Trfase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 61, "End": 400 }, { "InterPro-ID": "IPR000277", "InterPro-Name": "Cys/Met-Metab_PyrdxlP-dep_enz", "InterPro-Type": "FAMILY", "Beg": 20, "End": 399 }, { "InterPro-ID": "IPR015421", "InterPro-Name": "PyrdxlP-dep_Trfase_major", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 15, "End": 269 }, { "InterPro-ID": "IPR000277", "InterPro-Name": "Cys/Met-Metab_PyrdxlP-dep_enz", "InterPro-Type": "FAMILY", "Beg": 5, "End": 403 } ], "response#1": "MIAVNSRNSLNADMTSLHPETLMVHGGMKGLTEAGVHVPAIDLSTTNPVNDVATGGDSYEWLATGHTLKDGDSAVYQRLWQPGVARFETALAGLEHAEEAVAFATGMAAMTAALLAAVSAGTPHIVAVRPLYGGSDHLLETGLLGTTVTWAKEADIASAIQDDTGLVIVETPANPSLDLVDLDSVVSAAGNVPVLVDNTFCTPVLQQPISHGAALVLHSATKYLGGHGDAMGGIIATNADWAMRLRQVRAITGALLHPMGAYLLHRGLRTLAVRMRAAQTTAGELAERLDAHPAISVVHYPGLKGQDPRGLLGRQMSGGGAMIAMELAGGFDAARSFVEHCNLVVHAVSLGGADTLIQHPASLTHRPVAATAKPGDGLIRLSVGLEHVDDLADDLIAALDASRAAA", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Cys/Met-Metab_PyrdxlP-dep_enz, Cys/Met-Metab_PyrdxlP-dep_enz, Cys/Met-Metab_PyrdxlP-dep_enz that shares evolutionary origin and functional similarity; 2. The protein should be classified within PyrdxlP-dep_Trfase_small, PyrdxlP-dep_Trfase, PyrdxlP-dep_Trfase_major sharing conserved structural features. The designed protein sequence is ", "reference": "MIAVNSRNSLNADMTSLHPETLMVHGGMKGLTEAGVHVPAIDLSTTNPVNDVATGGDSYEWLATGHTLKDGDSAVYQRLWQPGVARFETALAGLEHAEEAVAFATGMAAMTAALLAAVSAGTPHIVAVRPLYGGSDHLLETGLLGTTVTWAKEADIASAIQDDTGLVIVETPANPSLDLVDLDSVVSAAGNVPVLVDNTFCTPVLQQPISHGAALVLHSATKYLGGHGDAMGGIIATNADWAMRLRQVRAITGALLHPMGAYLLHRGLRTLAVRMRAAQTTAGELAERLDAHPAISVVHYPGLKGQDPRGLLGRQMSGGGAMIAMELAGGFDAARSFVEHCNLVVHAVSLGGADTLIQHPASLTHRPVAATAKPGDGLIRLSVGLEHVDDLADDLIAALDASRAAA" }, { "InterPro": [ { "InterPro-ID": "IPR022596", "InterPro-Name": "GPR1_C", "InterPro-Type": "DOMAIN", "Beg": 318, "End": 386 }, { "InterPro-ID": "IPR017981", "InterPro-Name": "GPCR_2-like_7TM", "InterPro-Type": "DOMAIN", "Beg": 24, "End": 212 }, { "InterPro-ID": "IPR023041", "InterPro-Name": "Glucose_rcpt_Git3_N", "InterPro-Type": "DOMAIN", "Beg": 40, "End": 210 }, { "InterPro-ID": "IPR022343", "InterPro-Name": "GCR1-cAMP_receptor", "InterPro-Type": "FAMILY", "Beg": 99, "End": 117 }, { "InterPro-ID": "IPR022343", "InterPro-Name": "GCR1-cAMP_receptor", "InterPro-Type": "FAMILY", "Beg": 57, "End": 72 }, { "InterPro-ID": "IPR022343", "InterPro-Name": "GCR1-cAMP_receptor", "InterPro-Type": "FAMILY", "Beg": 38, "End": 56 }, { "InterPro-ID": "IPR017452", "InterPro-Name": "GPCR_Rhodpsn_7TM", "InterPro-Type": "DOMAIN", "Beg": 41, "End": 378 } ], "response#1": "MTQLPYLLDRRGGALAAPATAWGDMMLNRALFSVALLSSVGSAWVVLSYACIKELRSYRHQLILGLAISDLLMSLNFMFSAGWNVAGGDLALEESRTACSVNGFLTQVFVVQTDWWILVIAIATYIILGNFKTQSQFIQTHVWIPWVGPWVLSIIIAAICHGVLGYGYIGGWCWLTSDLMRLLINFIPRWLIVIAIALIYIRLYMIVRKARKWDIEGVSPDPGDDMADTSVILMSVGKKDRERQGSGVLVSRDVSVSFGRKGSTAPTFVTMVTTSGAGDSREAISSCSAREEGSRARTVNVNSSRSLSLGMRQPLNAAQLKRIAKKMMVYPVAYAIIWACPTAIRIYQGTTGSRAPLWITIVDKSCIVIQGLVDAVVYGLNERAWQGWRDHIRRIIYKNEGGRIIG", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more GPR1_C, GPCR_2-like_7TM, Glucose_rcpt_Git3_N, GPCR_Rhodpsn_7TM that are essential for its biological function; 2. The protein should belong to GCR1-cAMP_receptor, GCR1-cAMP_receptor, GCR1-cAMP_receptor that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MTQLPYLLDRRGGALAAPATAWGDMMLNRALFSVALLSSVGSAWVVLSYACIKELRSYRHQLILGLAISDLLMSLNFMFSAGWNVAGGDLALEESRTACSVNGFLTQVFVVQTDWWILVIAIATYIILGNFKTQSQFIQTHVWIPWVGPWVLSIIIAAICHGVLGYGYIGGWCWLTSDLMRLLINFIPRWLIVIAIALIYIRLYMIVRKARKWDIEGVSPDPGDDMADTSVILMSVGKKDRERQGSGVLVSRDVSVSFGRKGSTAPTFVTMVTTSGAGDSREAISSCSAREEGSRARTVNVNSSRSLSLGMRQPLNAAQLKRIAKKMMVYPVAYAIIWACPTAIRIYQGTTGSRAPLWITIVDKSCIVIQGLVDAVVYGLNERAWQGWRDHIRRIIYKNEGGRIIG" }, { "InterPro": [ { "InterPro-ID": "IPR029033", "InterPro-Name": "His_PPase_superfam", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 19, "End": 374 }, { "InterPro-ID": "IPR029033", "InterPro-Name": "His_PPase_superfam", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 19, "End": 372 }, { "InterPro-ID": "IPR050645", "InterPro-Name": "Histidine_acid_phosphatase", "InterPro-Type": "FAMILY", "Beg": 15, "End": 372 }, { "InterPro-ID": "IPR000560", "InterPro-Name": "His_Pase_clade-2", "InterPro-Type": "FAMILY", "Beg": 51, "End": 329 } ], "response#1": "TTIILLIAFAAIQLSKADDLKFVFVMARGGDFVAGDYAGGPKIINKEAKDSELTEQGKQEAFQLGTKLSELYKTKLGVSKWDSKTTYWPVALSQKRTQVSTLITGAGLEGDQSKRNKAWTNEELKATSFPAMESFSRFIKPNECPKYLEELMKQKQEISTILKECSSSVQQVKSKYSAVNVNLPQHIWLAYETLKKLKRQQPSSSTWMTDDLMKNLRECSAKITWLATTKTDTLRKLSGGLLLNDLFNDMDQITQGKAQPNAPGGKDSKLNVFTVSQFLVISQLAAFMPEGSKLNNKAVTASDIYPEDGSHVDIEMYQENNKWSVKLVYVSGKDKQPQTITLPGCQEKCPYEQFKSALQKYKITDEEHQKACKN", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Histidine_acid_phosphatase, His_Pase_clade-2 that shares evolutionary origin and functional similarity; 2. The protein should be classified within His_PPase_superfam, His_PPase_superfam sharing conserved structural features. The designed protein sequence is ", "reference": "TTIILLIAFAAIQLSKADDLKFVFVMARGGDFVAGDYAGGPKIINKEAKDSELTEQGKQEAFQLGTKLSELYKTKLGVSKWDSKTTYWPVALSQKRTQVSTLITGAGLEGDQSKRNKAWTNEELKATSFPAMESFSRFIKPNECPKYLEELMKQKQEISTILKECSSSVQQVKSKYSAVNVNLPQHIWLAYETLKKLKRQQPSSSTWMTDDLMKNLRECSAKITWLATTKTDTLRKLSGGLLLNDLFNDMDQITQGKAQPNAPGGKDSKLNVFTVSQFLVISQLAAFMPEGSKLNNKAVTASDIYPEDGSHVDIEMYQENNKWSVKLVYVSGKDKQPQTITLPGCQEKCPYEQFKSALQKYKITDEEHQKACKN" }, { "InterPro": [ { "InterPro-ID": "IPR052337", "InterPro-Name": "SAT4-like", "InterPro-Type": "FAMILY", "Beg": 106, "End": 394 }, { "InterPro-ID": "IPR049326", "InterPro-Name": "Rhodopsin_dom_fungi", "InterPro-Type": "DOMAIN", "Beg": 120, "End": 356 } ], "response#1": "MSGFVAGEEAVKSALSAATWIGAASPKYSHLVLSRVFNIYSEYIYANGFKLTRENLIEDFGTRPEDVDPFMKIFGGPNGIATYLTALPGLLPILPHPRNIPIIVPLFCVFTVMTSLAVGLRLWSRQKVAGGIRSFDWLALAGFGLTIIYGAVSVYHSKVSGPYQAFYDRTWDQMKENYKVYLVLTIMYPFIMGLIKISLLLFYYRVATLNYVQWAVYATGSLTIANSIAAIITHCLAFMPIDFWNHFLQSPFKFNSRTPMLVFGAVYILTDVAILIIPMPMVFQLKLYPREKVIAVIAFSLGGVACVASGFRIWAIDEFQNYSGKNSSGLMIDAWTMIELNLTLICASAPAIRALAIHYAPKILSTLPSAFSSSGATRGSKSAGSSGKSKTPESEKSMQVSQSPVIPKEVV", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Rhodopsin_dom_fungi that are essential for its biological function; 2. The protein should belong to SAT4-like that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MSGFVAGEEAVKSALSAATWIGAASPKYSHLVLSRVFNIYSEYIYANGFKLTRENLIEDFGTRPEDVDPFMKIFGGPNGIATYLTALPGLLPILPHPRNIPIIVPLFCVFTVMTSLAVGLRLWSRQKVAGGIRSFDWLALAGFGLTIIYGAVSVYHSKVSGPYQAFYDRTWDQMKENYKVYLVLTIMYPFIMGLIKISLLLFYYRVATLNYVQWAVYATGSLTIANSIAAIITHCLAFMPIDFWNHFLQSPFKFNSRTPMLVFGAVYILTDVAILIIPMPMVFQLKLYPREKVIAVIAFSLGGVACVASGFRIWAIDEFQNYSGKNSSGLMIDAWTMIELNLTLICASAPAIRALAIHYAPKILSTLPSAFSSSGATRGSKSAGSSGKSKTPESEKSMQVSQSPVIPKEVV" }, { "InterPro": [ { "InterPro-ID": "IPR020892", "InterPro-Name": "Cyclophilin-type_PPIase_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 55, "End": 72 }, { "InterPro-ID": "IPR002130", "InterPro-Name": "Cyclophilin-type_PPIase_dom", "InterPro-Type": "DOMAIN", "Beg": 24, "End": 39 }, { "InterPro-ID": "IPR002130", "InterPro-Name": "Cyclophilin-type_PPIase_dom", "InterPro-Type": "DOMAIN", "Beg": 131, "End": 146 }, { "InterPro-ID": "IPR002130", "InterPro-Name": "Cyclophilin-type_PPIase_dom", "InterPro-Type": "DOMAIN", "Beg": 118, "End": 130 }, { "InterPro-ID": "IPR002130", "InterPro-Name": "Cyclophilin-type_PPIase_dom", "InterPro-Type": "DOMAIN", "Beg": 103, "End": 118 }, { "InterPro-ID": "IPR002130", "InterPro-Name": "Cyclophilin-type_PPIase_dom", "InterPro-Type": "DOMAIN", "Beg": 60, "End": 72 }, { "InterPro-ID": "IPR002130", "InterPro-Name": "Cyclophilin-type_PPIase_dom", "InterPro-Type": "DOMAIN", "Beg": 7, "End": 170 }, { "InterPro-ID": "IPR002130", "InterPro-Name": "Cyclophilin-type_PPIase_dom", "InterPro-Type": "DOMAIN", "Beg": 7, "End": 169 }, { "InterPro-ID": "IPR024936", "InterPro-Name": "Cyclophilin-type_PPIase", "InterPro-Type": "FAMILY", "Beg": 1, "End": 172 }, { "InterPro-ID": "IPR029000", "InterPro-Name": "Cyclophilin-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1, "End": 172 }, { "InterPro-ID": "IPR029000", "InterPro-Name": "Cyclophilin-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 2, "End": 171 } ], "response#1": "MPNPKVFFDMTIGGQPAGRIVMELYADVTPSTAENFRALCTGEKGAGRSGKPLHYKGSSFHRVIPNFMCQGGDFTAGNGTGGESIYGAKFADENFVKKHTGPGILSMANAGPGTNGSQFFICTTKTEWLDGKHVVFGQVVEGMDVVKEIEKVGSSSGRTAKPVVVADCGQLS", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Cyclophilin-type_PPIase_dom, Cyclophilin-type_PPIase_dom, Cyclophilin-type_PPIase_dom, Cyclophilin-type_PPIase_dom, Cyclophilin-type_PPIase_dom, Cyclophilin-type_PPIase_dom, Cyclophilin-type_PPIase_dom that are essential for its biological function; 2. The protein should belong to Cyclophilin-type_PPIase that shares evolutionary origin and functional similarity; 3. The protein should be classified within Cyclophilin-like_dom_sf, Cyclophilin-like_dom_sf sharing conserved structural features; 4. The protein should contain Cyclophilin-type_PPIase_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MPNPKVFFDMTIGGQPAGRIVMELYADVTPSTAENFRALCTGEKGAGRSGKPLHYKGSSFHRVIPNFMCQGGDFTAGNGTGGESIYGAKFADENFVKKHTGPGILSMANAGPGTNGSQFFICTTKTEWLDGKHVVFGQVVEGMDVVKEIEKVGSSSGRTAKPVVVADCGQLS" }, { "InterPro": [ { "InterPro-ID": "IPR027443", "InterPro-Name": "IPNS-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1, "End": 310 }, { "InterPro-ID": "IPR026992", "InterPro-Name": "DIOX_N", "InterPro-Type": "DOMAIN", "Beg": 8, "End": 129 }, { "InterPro-ID": "IPR044861", "InterPro-Name": "IPNS-like_FE2OG_OXY", "InterPro-Type": "DOMAIN", "Beg": 182, "End": 277 }, { "InterPro-ID": "IPR005123", "InterPro-Name": "Oxoglu/Fe-dep_dioxygenase_dom", "InterPro-Type": "DOMAIN", "Beg": 172, "End": 279 }, { "InterPro-ID": "IPR050231", "InterPro-Name": "Iron_ascorbate_oxido_reductase", "InterPro-Type": "FAMILY", "Beg": 8, "End": 287 } ], "response#1": "MTVTKIEIPTIDLRGYYEPTSPTSKEEVVAQVRAACLEHGFFQIEGHGVSLEVQRNMLAACKTFFDLPTDQKAELSLYKNTWRRGYEGYGEQTPHHAVLPDQKEAFFVGRDLPEDQIGFLKGPNVWPEQVPTNQFRGPVEEYFEALLKLGHRVMEVLVVGMGHPPSILDSFTGNAAMFLKLLRYPEHTFTDPRVFGSGAHTDYGGLTILLQDPGKHGLEVYHAATEQWIPVPAVEDRFVINLGDMVQRWTDGEYKSNLHRVLNKASGERFAVPAFWHGDLEATNPLNPNDTSGETVQDFIRKKFYRDYSLPLAEEKGTAVAV", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more DIOX_N, IPNS-like_FE2OG_OXY, Oxoglu/Fe-dep_dioxygenase_dom that are essential for its biological function; 2. The protein should belong to Iron_ascorbate_oxido_reductase that shares evolutionary origin and functional similarity; 3. The protein should be classified within IPNS-like_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MTVTKIEIPTIDLRGYYEPTSPTSKEEVVAQVRAACLEHGFFQIEGHGVSLEVQRNMLAACKTFFDLPTDQKAELSLYKNTWRRGYEGYGEQTPHHAVLPDQKEAFFVGRDLPEDQIGFLKGPNVWPEQVPTNQFRGPVEEYFEALLKLGHRVMEVLVVGMGHPPSILDSFTGNAAMFLKLLRYPEHTFTDPRVFGSGAHTDYGGLTILLQDPGKHGLEVYHAATEQWIPVPAVEDRFVINLGDMVQRWTDGEYKSNLHRVLNKASGERFAVPAFWHGDLEATNPLNPNDTSGETVQDFIRKKFYRDYSLPLAEEKGTAVAV" }, { "InterPro": [ { "InterPro-ID": "IPR013087", "InterPro-Name": "Znf_C2H2_type", "InterPro-Type": "DOMAIN", "Beg": 151, "End": 173 }, { "InterPro-ID": "IPR036236", "InterPro-Name": "Znf_C2H2_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 72, "End": 130 }, { "InterPro-ID": "IPR013087", "InterPro-Name": "Znf_C2H2_type", "InterPro-Type": "DOMAIN", "Beg": 123, "End": 143 }, { "InterPro-ID": "IPR013087", "InterPro-Name": "Znf_C2H2_type", "InterPro-Type": "DOMAIN", "Beg": 149, "End": 178 }, { "InterPro-ID": "IPR013087", "InterPro-Name": "Znf_C2H2_type", "InterPro-Type": "DOMAIN", "Beg": 91, "End": 115 }, { "InterPro-ID": "IPR013087", "InterPro-Name": "Znf_C2H2_type", "InterPro-Type": "DOMAIN", "Beg": 149, "End": 173 }, { "InterPro-ID": "IPR013087", "InterPro-Name": "Znf_C2H2_type", "InterPro-Type": "DOMAIN", "Beg": 121, "End": 143 }, { "InterPro-ID": "IPR013087", "InterPro-Name": "Znf_C2H2_type", "InterPro-Type": "DOMAIN", "Beg": 63, "End": 85 }, { "InterPro-ID": "IPR013087", "InterPro-Name": "Znf_C2H2_type", "InterPro-Type": "DOMAIN", "Beg": 93, "End": 115 }, { "InterPro-ID": "IPR013087", "InterPro-Name": "Znf_C2H2_type", "InterPro-Type": "DOMAIN", "Beg": 91, "End": 120 }, { "InterPro-ID": "IPR013087", "InterPro-Name": "Znf_C2H2_type", "InterPro-Type": "DOMAIN", "Beg": 65, "End": 85 }, { "InterPro-ID": "IPR013087", "InterPro-Name": "Znf_C2H2_type", "InterPro-Type": "DOMAIN", "Beg": 63, "End": 90 }, { "InterPro-ID": "IPR013087", "InterPro-Name": "Znf_C2H2_type", "InterPro-Type": "DOMAIN", "Beg": 121, "End": 148 }, { "InterPro-ID": "IPR036236", "InterPro-Name": "Znf_C2H2_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 115, "End": 169 } ], "response#1": "MSGHLQAARPYGSPTSMHASLHMPEPNMGPSGMAFPSMAPELYAPPQPLRAPDATSQPAPKAYACSTCGKGFARRSDLARHERIHTGVRPHVCEYPNCGKQFIQRSALTVHQRVHTGEKPHMCERCGKPFSDSSSLARHRRIHSGKRPYKCPYADCQKTFTRRTTLTRHQNHHTGTVEDAARATAEVLARNSVARSASARPTRSEGDQISNHGSPLSTPSPAQRTMSMSPSAELAAANGMQHQYNGNSSLPAHMRTDLHSSSPAATTSSGFSSNVRPTSHPNAYGAAPPPTTLEPSIEGSQGPGSAVGSPHMSSVGWASPSHVASPAHSNSGGNSSYVYPDPDSSYPTNAAAQGQMFYSAAMGLQRPGSAEPGAQSAYKPRQNELWAA", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Znf_C2H2_type, Znf_C2H2_type, Znf_C2H2_type, Znf_C2H2_type, Znf_C2H2_type, Znf_C2H2_type, Znf_C2H2_type, Znf_C2H2_type, Znf_C2H2_type, Znf_C2H2_type, Znf_C2H2_type, Znf_C2H2_type that are essential for its biological function; 2. The protein should be classified within Znf_C2H2_sf, Znf_C2H2_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MSGHLQAARPYGSPTSMHASLHMPEPNMGPSGMAFPSMAPELYAPPQPLRAPDATSQPAPKAYACSTCGKGFARRSDLARHERIHTGVRPHVCEYPNCGKQFIQRSALTVHQRVHTGEKPHMCERCGKPFSDSSSLARHRRIHSGKRPYKCPYADCQKTFTRRTTLTRHQNHHTGTVEDAARATAEVLARNSVARSASARPTRSEGDQISNHGSPLSTPSPAQRTMSMSPSAELAAANGMQHQYNGNSSLPAHMRTDLHSSSPAATTSSGFSSNVRPTSHPNAYGAAPPPTTLEPSIEGSQGPGSAVGSPHMSSVGWASPSHVASPAHSNSGGNSSYVYPDPDSSYPTNAAAQGQMFYSAAMGLQRPGSAEPGAQSAYKPRQNELWAA" }, { "InterPro": [ { "InterPro-ID": "IPR004114", "InterPro-Name": "THUMP_dom", "InterPro-Type": "DOMAIN", "Beg": 149, "End": 264 }, { "InterPro-ID": "IPR000241", "InterPro-Name": "RlmKL-like_Mtase", "InterPro-Type": "DOMAIN", "Beg": 272, "End": 410 }, { "InterPro-ID": "IPR029063", "InterPro-Name": "SAM-dependent_MTases_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 270, "End": 421 }, { "InterPro-ID": "IPR004114", "InterPro-Name": "THUMP_dom", "InterPro-Type": "DOMAIN", "Beg": 176, "End": 264 }, { "InterPro-ID": "IPR004114", "InterPro-Name": "THUMP_dom", "InterPro-Type": "DOMAIN", "Beg": 186, "End": 254 }, { "InterPro-ID": "IPR029063", "InterPro-Name": "SAM-dependent_MTases_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 284, "End": 406 } ], "response#1": "MAVVPGGPSSRPAVGAQFFCTAGRGLEPFLMREVRERLAATQVEYISGKVFFTTCSDLNMLKQLKSAERLFLLIKKQLPFPVSSVSKGKILNELQRLINDDPESWLNAISIWKNLLELDAKKEKLSHKNANPLKRKVGEDDITAKKLKTEQIQELQETKECQLEKQIEEKILEQGNFITEGEKFQKLQDDVTEAVDTRNQTNLTFRVSCRCSGAVAKTLTAQEVGRVIGIALMKQFGWKADLRNPNLEIFIHLSDVYSVLGIPVFRVPLACRAYIKTAGLRSTIAWAMASLAEIKAGAVVLDPMCGLGTILLEAAKEWPHVYYVGADVSDSQLSGAYDNLRAAGLRDKIELLQVSVIELPLPSESVDIIISDIPFGKKFKLGKDIKRMLQEMERVLRVGGTIVLLLSEDHHRHLKGGEASSGPLNSQGGHTEEPGGEERLTPAEKAAVSEPVSSPFAASNQGRLDRMPPLGSLVPVDCYRVSLGKTDALISKYKKSHSPGR", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more THUMP_dom, RlmKL-like_Mtase, THUMP_dom, THUMP_dom that are essential for its biological function; 2. The protein should be classified within SAM-dependent_MTases_sf, SAM-dependent_MTases_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MAVVPGGPSSRPAVGAQFFCTAGRGLEPFLMREVRERLAATQVEYISGKVFFTTCSDLNMLKQLKSAERLFLLIKKQLPFPVSSVSKGKILNELQRLINDDPESWLNAISIWKNLLELDAKKEKLSHKNANPLKRKVGEDDITAKKLKTEQIQELQETKECQLEKQIEEKILEQGNFITEGEKFQKLQDDVTEAVDTRNQTNLTFRVSCRCSGAVAKTLTAQEVGRVIGIALMKQFGWKADLRNPNLEIFIHLSDVYSVLGIPVFRVPLACRAYIKTAGLRSTIAWAMASLAEIKAGAVVLDPMCGLGTILLEAAKEWPHVYYVGADVSDSQLSGAYDNLRAAGLRDKIELLQVSVIELPLPSESVDIIISDIPFGKKFKLGKDIKRMLQEMERVLRVGGTIVLLLSEDHHRHLKGGEASSGPLNSQGGHTEEPGGEERLTPAEKAAVSEPVSSPFAASNQGRLDRMPPLGSLVPVDCYRVSLGKTDALISKYKKSHSPGR" }, { "InterPro": [ { "InterPro-ID": "IPR013083", "InterPro-Name": "Znf_RING/FYVE/PHD", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1075, "End": 1181 }, { "InterPro-ID": "IPR001607", "InterPro-Name": "Znf_UBP", "InterPro-Type": "DOMAIN", "Beg": 1101, "End": 1162 }, { "InterPro-ID": "IPR000286", "InterPro-Name": "His_deacetylse", "InterPro-Type": "FAMILY", "Beg": 762, "End": 772 }, { "InterPro-ID": "IPR000286", "InterPro-Name": "His_deacetylse", "InterPro-Type": "FAMILY", "Beg": 672, "End": 687 }, { "InterPro-ID": "IPR000286", "InterPro-Name": "His_deacetylse", "InterPro-Type": "FAMILY", "Beg": 637, "End": 660 }, { "InterPro-ID": "IPR050284", "InterPro-Name": "HDAC_PDAC", "InterPro-Type": "FAMILY", "Beg": 508, "End": 866 }, { "InterPro-ID": "IPR001607", "InterPro-Name": "Znf_UBP", "InterPro-Type": "DOMAIN", "Beg": 1100, "End": 1149 }, { "InterPro-ID": "IPR023801", "InterPro-Name": "His_deacetylse_dom", "InterPro-Type": "DOMAIN", "Beg": 530, "End": 827 }, { "InterPro-ID": "IPR023801", "InterPro-Name": "His_deacetylse_dom", "InterPro-Type": "DOMAIN", "Beg": 105, "End": 430 }, { "InterPro-ID": "IPR023696", "InterPro-Name": "Ureohydrolase_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 83, "End": 468 }, { "InterPro-ID": "IPR023696", "InterPro-Name": "Ureohydrolase_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 508, "End": 864 }, { "InterPro-ID": "IPR037138", "InterPro-Name": "His_deacetylse_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 79, "End": 493 }, { "InterPro-ID": "IPR037138", "InterPro-Name": "His_deacetylse_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 506, "End": 882 }, { "InterPro-ID": "IPR001607", "InterPro-Name": "Znf_UBP", "InterPro-Type": "DOMAIN", "Beg": 1079, "End": 1177 } ], "response#1": "MTSTGQDSSTRQRKSRHNPQSPLQDSSATLKRGGKKGAVPHSSPNLAEVKKKGKMKKLSQPAEEDLIVGLQGLDLNSETRVPVGTGLVFDEQLNDFHCLWDDSFPENPERLHAIKEQLILEGLLGRCVSFQARFAEKEELMLVHSLEYIDLMETTQYMNEGELRVLAGTYDSVYLHPNSYSCACLATGSVLRLVDAVMGAEIRNGMAVIRPPGHHAQRSLMDGYCMFNHLAVAARYAQKKHRIQRILIVDWDVHHGQGTQFIFDQDPSVLYFSIHRYEHGRFWPHLKASNWSTTGFGQGQGYTINVPWNQVSFCSHKLSLACFPRGSREMTDYYIAFLCLQVGMRDADYIAAFLHILLPVAFEFQPQLVLVAAGFDALHGDPKGEMSATPAGFAHLTHFLMGLAGGKLILSLEGGYNLHALAKGVSGSLHTLLGDPCPMLESPVAPCASAQTSISCTLEALEPFWEVLERSVEPQDEDEVEGDMLEDEEEEGHWEATALPMDTWPLLQNRTGLVYDERMMSHCNLWDNHHPETPQRILRIMCHLEEVGLAARCLILPARPALDSELLTCHSAEYVERLRATEKMKTRDLHREGANFESIYICPSTFACAQLATGAACRLVEAVLSGEVLNGIAIVRPPGHHAEPDAACGFCFFNSVAVAARHAQVIAGRALRILIVDWDVHHGNGTQHIFEEDPSVLYVSLHRYDRGTFFPMGDEGASSQVGRAAGTGFTVNVPWNGPRMGDADYLATWHRLVLPIAYEFNPELVLISAGFDAAQGDPLGGCQVTPEGYAHLTHLLMGLAGGRIILILEGGYNLTSISESMAACTHSLLGDPPPQLTSLRPPQSGALASISEVIQVHRKYWRSLRLMKMEDKEERSSSRLVIKKLPQSASPVSAKGMTTPKGKVLEAGMRKPTAALPTKESTLGQAKAKTAKALLAQGQSSEQAAKGTTLDLATSKDTVGGATTDQCASVAATENSANQTTSGEEASGETESFGTSPSSNASKQTTGASPLHGAAAQQSPELGLSSTLELSSEAQEVQESEEGLLGEAAGGQDMNSLMLTQGFGDFNTQDVFYAVTPLSWCPHLMAVCPIPAAGLDVSQPCKTCGSVQENWVCLTCYQVYCSRYVNAHMVCHHEASEHPLVLSCVDLSTWCYLCQAYVHHEDLQDVKNAAHQNKFGEGMPHLQ", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Znf_UBP, Znf_UBP, His_deacetylse_dom, His_deacetylse_dom, Znf_UBP that are essential for its biological function; 2. The protein should belong to His_deacetylse, His_deacetylse, His_deacetylse, HDAC_PDAC that shares evolutionary origin and functional similarity; 3. The protein should be classified within Znf_RING/FYVE/PHD, Ureohydrolase_dom_sf, Ureohydrolase_dom_sf, His_deacetylse_dom_sf, His_deacetylse_dom_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MTSTGQDSSTRQRKSRHNPQSPLQDSSATLKRGGKKGAVPHSSPNLAEVKKKGKMKKLSQPAEEDLIVGLQGLDLNSETRVPVGTGLVFDEQLNDFHCLWDDSFPENPERLHAIKEQLILEGLLGRCVSFQARFAEKEELMLVHSLEYIDLMETTQYMNEGELRVLAGTYDSVYLHPNSYSCACLATGSVLRLVDAVMGAEIRNGMAVIRPPGHHAQRSLMDGYCMFNHLAVAARYAQKKHRIQRILIVDWDVHHGQGTQFIFDQDPSVLYFSIHRYEHGRFWPHLKASNWSTTGFGQGQGYTINVPWNQVSFCSHKLSLACFPRGSREMTDYYIAFLCLQVGMRDADYIAAFLHILLPVAFEFQPQLVLVAAGFDALHGDPKGEMSATPAGFAHLTHFLMGLAGGKLILSLEGGYNLHALAKGVSGSLHTLLGDPCPMLESPVAPCASAQTSISCTLEALEPFWEVLERSVEPQDEDEVEGDMLEDEEEEGHWEATALPMDTWPLLQNRTGLVYDERMMSHCNLWDNHHPETPQRILRIMCHLEEVGLAARCLILPARPALDSELLTCHSAEYVERLRATEKMKTRDLHREGANFESIYICPSTFACAQLATGAACRLVEAVLSGEVLNGIAIVRPPGHHAEPDAACGFCFFNSVAVAARHAQVIAGRALRILIVDWDVHHGNGTQHIFEEDPSVLYVSLHRYDRGTFFPMGDEGASSQVGRAAGTGFTVNVPWNGPRMGDADYLATWHRLVLPIAYEFNPELVLISAGFDAAQGDPLGGCQVTPEGYAHLTHLLMGLAGGRIILILEGGYNLTSISESMAACTHSLLGDPPPQLTSLRPPQSGALASISEVIQVHRKYWRSLRLMKMEDKEERSSSRLVIKKLPQSASPVSAKGMTTPKGKVLEAGMRKPTAALPTKESTLGQAKAKTAKALLAQGQSSEQAAKGTTLDLATSKDTVGGATTDQCASVAATENSANQTTSGEEASGETESFGTSPSSNASKQTTGASPLHGAAAQQSPELGLSSTLELSSEAQEVQESEEGLLGEAAGGQDMNSLMLTQGFGDFNTQDVFYAVTPLSWCPHLMAVCPIPAAGLDVSQPCKTCGSVQENWVCLTCYQVYCSRYVNAHMVCHHEASEHPLVLSCVDLSTWCYLCQAYVHHEDLQDVKNAAHQNKFGEGMPHLQ" }, { "InterPro": [ { "InterPro-ID": "IPR000084", "InterPro-Name": "PE-PGRS_N", "InterPro-Type": "DOMAIN", "Beg": 70, "End": 126 } ], "response#1": "MRSMGFLHRACRAPSSLPAPLMARPGRSVLARPAATPPGPLCATTRPRPPQGNQPPASRISNFPPKRHKTRVLAAAEDEVSAAVAALISAHGRRHHSLNNQAAAFHGQFAQNLNVGAGSCASAETTADAPTQALLGPADRQRRQRRAVRQWLVRWAAHPGRATRGFHNHRQ", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more PE-PGRS_N that are essential for its biological function. The designed protein sequence is ", "reference": "MRSMGFLHRACRAPSSLPAPLMARPGRSVLARPAATPPGPLCATTRPRPPQGNQPPASRISNFPPKRHKTRVLAAAEDEVSAAVAALISAHGRRHHSLNNQAAAFHGQFAQNLNVGAGSCASAETTADAPTQALLGPADRQRRQRRAVRQWLVRWAAHPGRATRGFHNHRQ" }, { "InterPro": [ { "InterPro-ID": "IPR036551", "InterPro-Name": "Flavin_trans-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 22, "End": 210 }, { "InterPro-ID": "IPR036551", "InterPro-Name": "Flavin_trans-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 22, "End": 199 }, { "InterPro-ID": "IPR003382", "InterPro-Name": "Flavoprotein", "InterPro-Type": "DOMAIN", "Beg": 24, "End": 196 } ], "response#1": "MAGSEPVRAEGETMAVDAAPRKPRILLAASGSVAAVKFANLCHCFSEWADVRAVSTSASLHFIDRAAMPKDVILYTDDNEWSSWKKLGDSVLHIELRKWADIMVIAPLSANTLGKIAGGLCDNLLTCIVRAWDYSKPFFVAPAMNTFMWNNPFTERHLISIDELGISLIPPVTKRLACGDYGNGAMAEPSTIYSTVRLFYESKAQQGNGDI", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Flavoprotein that are essential for its biological function; 2. The protein should be classified within Flavin_trans-like, Flavin_trans-like sharing conserved structural features. The designed protein sequence is ", "reference": "MAGSEPVRAEGETMAVDAAPRKPRILLAASGSVAAVKFANLCHCFSEWADVRAVSTSASLHFIDRAAMPKDVILYTDDNEWSSWKKLGDSVLHIELRKWADIMVIAPLSANTLGKIAGGLCDNLLTCIVRAWDYSKPFFVAPAMNTFMWNNPFTERHLISIDELGISLIPPVTKRLACGDYGNGAMAEPSTIYSTVRLFYESKAQQGNGDI" }, { "InterPro": [ { "InterPro-ID": "IPR018566", "InterPro-Name": "MeMu_Me-Isoase", "InterPro-Type": "DOMAIN", "Beg": 1, "End": 106 }, { "InterPro-ID": "IPR011008", "InterPro-Name": "Dimeric_a/b-barrel", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1, "End": 106 } ], "response#1": "MIRILYLLVKPESMSHEQFRKECVVHFQMSAGMPGLHKYEVRLVAGNPTDTHVPYLDVGRIDAIGECWFASEEQYQVYMESDIRKAWFEHGKYFIGQLKPFVTEELV", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more MeMu_Me-Isoase that are essential for its biological function; 2. The protein should be classified within Dimeric_a/b-barrel sharing conserved structural features. The designed protein sequence is ", "reference": "MIRILYLLVKPESMSHEQFRKECVVHFQMSAGMPGLHKYEVRLVAGNPTDTHVPYLDVGRIDAIGECWFASEEQYQVYMESDIRKAWFEHGKYFIGQLKPFVTEELV" }, { "InterPro": [ { "InterPro-ID": "IPR048949", "InterPro-Name": "PriA-like_WH", "InterPro-Type": "DOMAIN", "Beg": 113, "End": 175 }, { "InterPro-ID": "IPR011545", "InterPro-Name": "DEAD/DEAH_box_helicase_dom", "InterPro-Type": "DOMAIN", "Beg": 202, "End": 365 }, { "InterPro-ID": "IPR005259", "InterPro-Name": "PriA", "InterPro-Type": "FAMILY", "Beg": 6, "End": 731 }, { "InterPro-ID": "IPR014001", "InterPro-Name": "Helicase_ATP-bd", "InterPro-Type": "DOMAIN", "Beg": 194, "End": 389 }, { "InterPro-ID": "IPR001650", "InterPro-Name": "Helicase_C-like", "InterPro-Type": "DOMAIN", "Beg": 470, "End": 637 }, { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 402, "End": 624 }, { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 183, "End": 378 }, { "InterPro-ID": "IPR014001", "InterPro-Name": "Helicase_ATP-bd", "InterPro-Type": "DOMAIN", "Beg": 210, "End": 376 }, { "InterPro-ID": "IPR001650", "InterPro-Name": "Helicase_C-like", "InterPro-Type": "DOMAIN", "Beg": 503, "End": 588 }, { "InterPro-ID": "IPR001650", "InterPro-Name": "Helicase_C-like", "InterPro-Type": "DOMAIN", "Beg": 491, "End": 588 }, { "InterPro-ID": "IPR005259", "InterPro-Name": "PriA", "InterPro-Type": "FAMILY", "Beg": 220, "End": 729 }, { "InterPro-ID": "IPR042115", "InterPro-Name": "PriA_3primeBD_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 2, "End": 112 }, { "InterPro-ID": "IPR050880", "InterPro-Name": "PriA_helicase", "InterPro-Type": "FAMILY", "Beg": 1, "End": 730 }, { "InterPro-ID": "IPR041236", "InterPro-Name": "PriA_C", "InterPro-Type": "DOMAIN", "Beg": 631, "End": 728 }, { "InterPro-ID": "IPR041222", "InterPro-Name": "PriA_3primeBD", "InterPro-Type": "DOMAIN", "Beg": 6, "End": 100 }, { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 212, "End": 600 }, { "InterPro-ID": "IPR040498", "InterPro-Name": "PriA_CRR", "InterPro-Type": "DOMAIN", "Beg": 444, "End": 470 } ], "response#1": "MSVAHVALPVPLPRTFDYLLPEGMAVKAGCRVRVPFGKQERIGIVAAVSERSELPLDELKPVAEALDDEPVFSTTVWRLLMWAAEYYHHPIGDVLFHALPVMLRQGKPASATPLWYWFATEQGQVVDLNGLKRSRKQQQALAALRQGKIWRHQVGELEFNEAALQALRGKGLAELACEAPALTDWRSAYSVAGERLRLNTEQATAVGAIHSAADRFSAWLLAGITGSGKTEVYLSVLENVLAQGRQALVMVPEIGLTPQTIARFRQRFNAPVEVLHSGLNDSERLSAWLKAKNGEAAIVIGTRSSLFTPFKDLGVIVIDEEHDSSYKQQEGWRYHARDLAVWRAHSEQIPIILGSATPALETLHNVRQGKYRQLTLSKRAGNARPAQQHVLDLKGQPLQAGLSPALISRMRQHLQADNQVILFLNRRGFAPALLCHDCGWIAECPRCDSYYTLHQAQHHLRCHHCDSQRPIPRQCPSCGSTHLVPVGIGTEQLEQALAPLFPEVPISRIDRDTTSRKGALEEHLAAVHRGGARILIGTQMLAKGHHFPDVTLVSLLDVDGALFSADFRSAERFAQLYTQVSGRAGRAGKQGEVILQTHHPEHPLLQTLLYKGYDAFAEQALAERQTMQLPPWTSHVLIRAEDHNNQQAPLFLQQLRNLLQASPLADEKLWVLGPVPALAPKRGGRWRWQILLQHPSRVRLQHIVSGTLALINTLPEARKVKWVLDVDPIEG", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more PriA-like_WH, DEAD/DEAH_box_helicase_dom, Helicase_ATP-bd, Helicase_C-like, Helicase_ATP-bd, Helicase_C-like, Helicase_C-like, PriA_C, PriA_3primeBD, PriA_CRR that are essential for its biological function; 2. The protein should belong to PriA, PriA, PriA_helicase that shares evolutionary origin and functional similarity; 3. The protein should be classified within P-loop_NTPase, P-loop_NTPase, PriA_3primeBD_sf, P-loop_NTPase sharing conserved structural features. The designed protein sequence is ", "reference": "MSVAHVALPVPLPRTFDYLLPEGMAVKAGCRVRVPFGKQERIGIVAAVSERSELPLDELKPVAEALDDEPVFSTTVWRLLMWAAEYYHHPIGDVLFHALPVMLRQGKPASATPLWYWFATEQGQVVDLNGLKRSRKQQQALAALRQGKIWRHQVGELEFNEAALQALRGKGLAELACEAPALTDWRSAYSVAGERLRLNTEQATAVGAIHSAADRFSAWLLAGITGSGKTEVYLSVLENVLAQGRQALVMVPEIGLTPQTIARFRQRFNAPVEVLHSGLNDSERLSAWLKAKNGEAAIVIGTRSSLFTPFKDLGVIVIDEEHDSSYKQQEGWRYHARDLAVWRAHSEQIPIILGSATPALETLHNVRQGKYRQLTLSKRAGNARPAQQHVLDLKGQPLQAGLSPALISRMRQHLQADNQVILFLNRRGFAPALLCHDCGWIAECPRCDSYYTLHQAQHHLRCHHCDSQRPIPRQCPSCGSTHLVPVGIGTEQLEQALAPLFPEVPISRIDRDTTSRKGALEEHLAAVHRGGARILIGTQMLAKGHHFPDVTLVSLLDVDGALFSADFRSAERFAQLYTQVSGRAGRAGKQGEVILQTHHPEHPLLQTLLYKGYDAFAEQALAERQTMQLPPWTSHVLIRAEDHNNQQAPLFLQQLRNLLQASPLADEKLWVLGPVPALAPKRGGRWRWQILLQHPSRVRLQHIVSGTLALINTLPEARKVKWVLDVDPIEG" }, { "InterPro": [ { "InterPro-ID": "IPR018095", "InterPro-Name": "Thymidylate_kin_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 95, "End": 107 }, { "InterPro-ID": "IPR039430", "InterPro-Name": "Thymidylate_kin-like_dom", "InterPro-Type": "DOMAIN", "Beg": 12, "End": 191 }, { "InterPro-ID": "IPR018094", "InterPro-Name": "Thymidylate_kinase", "InterPro-Type": "FAMILY", "Beg": 6, "End": 191 }, { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 2, "End": 211 }, { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 5, "End": 203 }, { "InterPro-ID": "IPR018094", "InterPro-Name": "Thymidylate_kinase", "InterPro-Type": "FAMILY", "Beg": 8, "End": 199 } ], "response#1": "MSAGKRGALIIFEGCDRSGKTTQSRLLVELLKSKGIPTLPMNFPERSSSIGQVINSYLTNSKDLPDEVIHLMFSANRWEHINQVKEKLLEGTTLVVDRYSFSGVAYSAAKGLDFDWCYAPERGLIKPDAVFYLRAPPNDLTHRGQYGKERYEKVEFQGRVAEVFNRICSKEGSYFHQFDARQSVEDLHAQIASITEELLPKVATRPLDTLS", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Thymidylate_kin-like_dom that are essential for its biological function; 2. The protein should belong to Thymidylate_kinase, Thymidylate_kinase that shares evolutionary origin and functional similarity; 3. The protein should be classified within P-loop_NTPase, P-loop_NTPase sharing conserved structural features; 4. The protein should contain Thymidylate_kin_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MSAGKRGALIIFEGCDRSGKTTQSRLLVELLKSKGIPTLPMNFPERSSSIGQVINSYLTNSKDLPDEVIHLMFSANRWEHINQVKEKLLEGTTLVVDRYSFSGVAYSAAKGLDFDWCYAPERGLIKPDAVFYLRAPPNDLTHRGQYGKERYEKVEFQGRVAEVFNRICSKEGSYFHQFDARQSVEDLHAQIASITEELLPKVATRPLDTLS" }, { "InterPro": [ { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 428, "End": 597 }, { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 14, "End": 215 }, { "InterPro-ID": "IPR021181", "InterPro-Name": "Miro", "InterPro-Type": "FAMILY", "Beg": 14, "End": 631 }, { "InterPro-ID": "IPR018247", "InterPro-Name": "EF_Hand_1_Ca_BS", "InterPro-Type": "BINDING_SITE", "Beg": 210, "End": 222 }, { "InterPro-ID": "IPR020860", "InterPro-Name": "MIRO_dom", "InterPro-Type": "DOMAIN", "Beg": 429, "End": 592 }, { "InterPro-ID": "IPR001806", "InterPro-Name": "Small_GTPase", "InterPro-Type": "FAMILY", "Beg": 20, "End": 182 }, { "InterPro-ID": "IPR013566", "InterPro-Name": "EF_hand_assoc_1", "InterPro-Type": "DOMAIN", "Beg": 354, "End": 426 }, { "InterPro-ID": "IPR002048", "InterPro-Name": "EF_hand_dom", "InterPro-Type": "DOMAIN", "Beg": 317, "End": 352 }, { "InterPro-ID": "IPR011992", "InterPro-Name": "EF-hand-dom_pair", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 181, "End": 381 }, { "InterPro-ID": "IPR001806", "InterPro-Name": "Small_GTPase", "InterPro-Type": "FAMILY", "Beg": 436, "End": 561 }, { "InterPro-ID": "IPR001806", "InterPro-Name": "Small_GTPase", "InterPro-Type": "FAMILY", "Beg": 19, "End": 179 }, { "InterPro-ID": "IPR005225", "InterPro-Name": "Small_GTP-bd", "InterPro-Type": "DOMAIN", "Beg": 16, "End": 175 }, { "InterPro-ID": "IPR052266", "InterPro-Name": "Miro-EF-hand_domain", "InterPro-Type": "FAMILY", "Beg": 149, "End": 455 }, { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 9, "End": 191 }, { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 490, "End": 591 }, { "InterPro-ID": "IPR020860", "InterPro-Name": "MIRO_dom", "InterPro-Type": "DOMAIN", "Beg": 15, "End": 181 }, { "InterPro-ID": "IPR013567", "InterPro-Name": "EF_hand_assoc_2", "InterPro-Type": "DOMAIN", "Beg": 232, "End": 317 } ], "response#1": "MRAGRVRPLRASDMKKDVRILLVGEPRVGKTSLIMSLVSEEFPEEVPPRAEEITIPADVTPERVPTHIVDYSEAEQSDEQLHQEISQANVICIVYAVNNKHSIDKVTSRWIPLINERTDKDSRLPLILVGNKSDLVEYSSMETILPIMNQYTEIETCVECSAKNLKNISELFYYAQKAVLHPTGPLYCPEEKEMKPACIKALTRIFKISDQDNDGTLNDAELNFFQRICFNTPLAPQALEDVKNVVRKHLSDGVADSGLTLRGFLFLHTLFIQRGRHETTWTVLRRFGYDDDLDLTPEYLFPLLKIPPDCTTELNHHAYLFLQSTFDKHDLDRDCALSPDELKDLFQVFPYIPWGPDVNNTVCTNESGWITYQGFLSQWTLTTYLDVQRCLEYLGYLGYSILTEQESQASAITVTRDKKIDLQKKQTQRNVFRCNVIGVKGCGKTGVLQSLLGRNLMRQKKIRDDHKSYYAINTVYVYGQEKYLLLHDISESEFLTEAEIVCDVVCLVYDVTNPKSFEYCARIFKQHFMDSRIPCLIVAAKSDLHEVKQEHSVSPTDFCRKHKMPPPQAFTCNTADAPSKDIFVKLTTMAMYPHVTQADLKSSTFWLRASFGATVFAVVGFAMYRALLKQR", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more MIRO_dom, EF_hand_assoc_1, EF_hand_dom, Small_GTP-bd, MIRO_dom, EF_hand_assoc_2 that are essential for its biological function; 2. The protein should belong to Miro, Small_GTPase, Small_GTPase, Small_GTPase, Miro-EF-hand_domain that shares evolutionary origin and functional similarity; 3. The protein should be classified within P-loop_NTPase, P-loop_NTPase, EF-hand-dom_pair, P-loop_NTPase, P-loop_NTPase sharing conserved structural features; 4. The protein should include a EF_Hand_1_Ca_BS that enables ligand binding under diverse conditions. The designed protein sequence is ", "reference": "MRAGRVRPLRASDMKKDVRILLVGEPRVGKTSLIMSLVSEEFPEEVPPRAEEITIPADVTPERVPTHIVDYSEAEQSDEQLHQEISQANVICIVYAVNNKHSIDKVTSRWIPLINERTDKDSRLPLILVGNKSDLVEYSSMETILPIMNQYTEIETCVECSAKNLKNISELFYYAQKAVLHPTGPLYCPEEKEMKPACIKALTRIFKISDQDNDGTLNDAELNFFQRICFNTPLAPQALEDVKNVVRKHLSDGVADSGLTLRGFLFLHTLFIQRGRHETTWTVLRRFGYDDDLDLTPEYLFPLLKIPPDCTTELNHHAYLFLQSTFDKHDLDRDCALSPDELKDLFQVFPYIPWGPDVNNTVCTNESGWITYQGFLSQWTLTTYLDVQRCLEYLGYLGYSILTEQESQASAITVTRDKKIDLQKKQTQRNVFRCNVIGVKGCGKTGVLQSLLGRNLMRQKKIRDDHKSYYAINTVYVYGQEKYLLLHDISESEFLTEAEIVCDVVCLVYDVTNPKSFEYCARIFKQHFMDSRIPCLIVAAKSDLHEVKQEHSVSPTDFCRKHKMPPPQAFTCNTADAPSKDIFVKLTTMAMYPHVTQADLKSSTFWLRASFGATVFAVVGFAMYRALLKQR" }, { "InterPro": [ { "InterPro-ID": "IPR018566", "InterPro-Name": "MeMu_Me-Isoase", "InterPro-Type": "DOMAIN", "Beg": 1, "End": 108 }, { "InterPro-ID": "IPR011008", "InterPro-Name": "Dimeric_a/b-barrel", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1, "End": 103 } ], "response#1": "MIRLLYLLVKPAGMSDETFRAECLRHYEMSHDVPGLHKYEVRLVAEQPTDTHVPFFDIGHVDAIGECWFKDDAAYATYMASDIRKAWFEHGKTFIGQLKPFRTAPVAGDEPAS", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more MeMu_Me-Isoase that are essential for its biological function; 2. The protein should be classified within Dimeric_a/b-barrel sharing conserved structural features. The designed protein sequence is ", "reference": "MIRLLYLLVKPAGMSDETFRAECLRHYEMSHDVPGLHKYEVRLVAEQPTDTHVPFFDIGHVDAIGECWFKDDAAYATYMASDIRKAWFEHGKTFIGQLKPFRTAPVAGDEPAS" }, { "InterPro": [ { "InterPro-ID": "IPR036640", "InterPro-Name": "ABC1_TM_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 405, "End": 845 }, { "InterPro-ID": "IPR011527", "InterPro-Name": "ABC1_TM_dom", "InterPro-Type": "DOMAIN", "Beg": 588, "End": 810 }, { "InterPro-ID": "IPR036640", "InterPro-Name": "ABC1_TM_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 421, "End": 844 }, { "InterPro-ID": "IPR011527", "InterPro-Name": "ABC1_TM_dom", "InterPro-Type": "DOMAIN", "Beg": 587, "End": 823 }, { "InterPro-ID": "IPR017871", "InterPro-Name": "ABC_transporter-like_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 1014, "End": 1028 }, { "InterPro-ID": "IPR039421", "InterPro-Name": "Type_1_exporter", "InterPro-Type": "FAMILY", "Beg": 389, "End": 1109 }, { "InterPro-ID": "IPR003439", "InterPro-Name": "ABC_transporter-like_ATP-bd", "InterPro-Type": "DOMAIN", "Beg": 857, "End": 1111 }, { "InterPro-ID": "IPR003593", "InterPro-Name": "AAA+_ATPase", "InterPro-Type": "DOMAIN", "Beg": 902, "End": 1088 }, { "InterPro-ID": "IPR003439", "InterPro-Name": "ABC_transporter-like_ATP-bd", "InterPro-Type": "DOMAIN", "Beg": 893, "End": 1042 }, { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 852, "End": 1127 }, { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 848, "End": 1113 } ], "response#1": "MQPPTRAPFFPFSLLRGRKARETCTCRSVASTEGPNTFGPRARPGCHAHQVAPSKESFHSSAFQLVSASRLSPLMSSCFVSFLRYPSFRPSAPFSAPPSSSTVPISTPSDFSHSAPASWRCVPTAPSALHAPFSFTTQAAHLSSCVFDGCSRLPCSEPGSPQTLQRALATTSATAFLRTACMSHRLRRRPDAWTSGCSGQTDNATASPCVRPLLRPPVDTASRAAANDKDAPQPTCFWRNARTSRAVHRNQTDMNFSSFSCSLRPCRHTLAKAAGHHAPLSRHSLQSLPESRIRGGTVSRGDSPGSLTLSPRNMSSDAMPVHPLYFPSAVPFSTTSGSNSSTFSCPSPSSSTSSTSSTSSTSSTSSTSSTSSTSSTSSTSSTSSPFLLSRSHSVDCRACPVSRAPPNPTSLQLLFSLFPFLWPTALKDRLRVLGSVACLVTAKVLTIQAPLLLANLVDAFQVLPHNSPLSPSGASPSSGDTSLLASSGETSSSLSPSAAPAEGAREAGKSGESAGRERRDEGSTVRLSPLAEGPASPATEERTAAGKAGTSVGGRDAGAVHALDTEHLRNTAQIVSVPLGVVCGFPVARIAATGFNELRSTLFTRVSQNASCDFSCHAFLHLHALALFHDKRAGELSVLISRGMKSVTALLNVLLFQMVPTALEFALVLYLLGSKVGGPVACITSLTMAVYVAFTAAVTARRTKIRKEMIAAEQQSVGLLVDSLANAEAVRFFTAEKGELSRFEAVQRRYAEKHVSVNQSLAFLNFGQQLIFNVGVLGSLAYTASQVAAGLLPVGHIVLVSSLLLQLAVPLNFVGTIYRETSLNLADLEKLYELMNHHPPIVNPPDARPFVLKGGAVAFENVRFAYPPSPLRPGSLPSKTGDDEKPEASRMLLDDVSFSVDAGKKVAIVGPSGVGKSTLIKLLFRMFDPASGTVRIDDQDVKELDLHSFRRQIGVVPQDMVLFNDTIEFNIKYGCPSATDEEMRAAAKQAEIDDVIMRMPQGYSTVVGERGLKLSGGERQRIGIARCLLRNPAIAVFDEATSALDSHTEQKILKAFRAMARGRTTLVIAHRLSTISDADKIIYLKEGKIAEMGTHAELLEKERGLYRALWESQQHQEQEEAVSTPDLTLS", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more ABC1_TM_dom, ABC1_TM_dom, ABC_transporter-like_ATP-bd, AAA+_ATPase, ABC_transporter-like_ATP-bd that are essential for its biological function; 2. The protein should belong to Type_1_exporter that shares evolutionary origin and functional similarity; 3. The protein should be classified within ABC1_TM_sf, ABC1_TM_sf, P-loop_NTPase, P-loop_NTPase sharing conserved structural features; 4. The protein should contain ABC_transporter-like_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MQPPTRAPFFPFSLLRGRKARETCTCRSVASTEGPNTFGPRARPGCHAHQVAPSKESFHSSAFQLVSASRLSPLMSSCFVSFLRYPSFRPSAPFSAPPSSSTVPISTPSDFSHSAPASWRCVPTAPSALHAPFSFTTQAAHLSSCVFDGCSRLPCSEPGSPQTLQRALATTSATAFLRTACMSHRLRRRPDAWTSGCSGQTDNATASPCVRPLLRPPVDTASRAAANDKDAPQPTCFWRNARTSRAVHRNQTDMNFSSFSCSLRPCRHTLAKAAGHHAPLSRHSLQSLPESRIRGGTVSRGDSPGSLTLSPRNMSSDAMPVHPLYFPSAVPFSTTSGSNSSTFSCPSPSSSTSSTSSTSSTSSTSSTSSTSSTSSTSSTSSTSSPFLLSRSHSVDCRACPVSRAPPNPTSLQLLFSLFPFLWPTALKDRLRVLGSVACLVTAKVLTIQAPLLLANLVDAFQVLPHNSPLSPSGASPSSGDTSLLASSGETSSSLSPSAAPAEGAREAGKSGESAGRERRDEGSTVRLSPLAEGPASPATEERTAAGKAGTSVGGRDAGAVHALDTEHLRNTAQIVSVPLGVVCGFPVARIAATGFNELRSTLFTRVSQNASCDFSCHAFLHLHALALFHDKRAGELSVLISRGMKSVTALLNVLLFQMVPTALEFALVLYLLGSKVGGPVACITSLTMAVYVAFTAAVTARRTKIRKEMIAAEQQSVGLLVDSLANAEAVRFFTAEKGELSRFEAVQRRYAEKHVSVNQSLAFLNFGQQLIFNVGVLGSLAYTASQVAAGLLPVGHIVLVSSLLLQLAVPLNFVGTIYRETSLNLADLEKLYELMNHHPPIVNPPDARPFVLKGGAVAFENVRFAYPPSPLRPGSLPSKTGDDEKPEASRMLLDDVSFSVDAGKKVAIVGPSGVGKSTLIKLLFRMFDPASGTVRIDDQDVKELDLHSFRRQIGVVPQDMVLFNDTIEFNIKYGCPSATDEEMRAAAKQAEIDDVIMRMPQGYSTVVGERGLKLSGGERQRIGIARCLLRNPAIAVFDEATSALDSHTEQKILKAFRAMARGRTTLVIAHRLSTISDADKIIYLKEGKIAEMGTHAELLEKERGLYRALWESQQHQEQEEAVSTPDLTLS" }, { "InterPro": [ { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 345, "End": 356 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 289, "End": 306 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 417, "End": 426 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 426, "End": 437 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 416, "End": 426 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 278, "End": 295 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 426, "End": 449 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 384, "End": 408 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 35, "End": 451 }, { "InterPro-ID": "IPR036396", "InterPro-Name": "Cyt_P450_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 30, "End": 476 }, { "InterPro-ID": "IPR017972", "InterPro-Name": "Cyt_P450_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 419, "End": 428 }, { "InterPro-ID": "IPR036396", "InterPro-Name": "Cyt_P450_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 23, "End": 477 } ], "response#1": "MELFFICGLVLFSTLSLISLFLLHNHSSARGYRLPPGRMGWPFIGESYEFLANGWKGYPEKFIFSRLAKYKPNQVFKTSILGEKVAVMCGATCNKFLFSNEGKLVNAWWPNSVNKIFPSSTQTSSKEEAKKMRKLLPTFFKPEALQRYIPIMDEIAIRHMEDEWEGKSKIEVFPLAKRYTFWLACRLFLSIDDPVHVAKFADPFNDIASGIISIPIDLPGTPFNRGIKASNVVRQELKTIIKQRKLDLSDNKASPTQDILSHMLLTPDEDGRYMNELDIADKILGLLIGGHDTASAACTFVVKFLAELPHIYDGVYKEQMEIAKSKKEGERLNWEDIQKMKYSWNVACEVMRLAPPLQGAFREALSDFMYAGFQIPKGWKLYWSANSTHRNPECFPEPEKFDPARFDGSGPAPYTYVPFGGGPRMCPGKEYARLEILVFMHNIVKRFKWEKLIPDETIVVNPMPTPAKGLPVRLRPHSKPVTVSA", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Cyt_P450, Cyt_P450, Cyt_P450, Cyt_P450, Cyt_P450_E_grp-I, Cyt_P450_E_grp-I, Cyt_P450_E_grp-I, Cyt_P450_E_grp-I, Cyt_P450 that shares evolutionary origin and functional similarity; 2. The protein should be classified within Cyt_P450_sf, Cyt_P450_sf sharing conserved structural features; 3. The protein should contain Cyt_P450_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MELFFICGLVLFSTLSLISLFLLHNHSSARGYRLPPGRMGWPFIGESYEFLANGWKGYPEKFIFSRLAKYKPNQVFKTSILGEKVAVMCGATCNKFLFSNEGKLVNAWWPNSVNKIFPSSTQTSSKEEAKKMRKLLPTFFKPEALQRYIPIMDEIAIRHMEDEWEGKSKIEVFPLAKRYTFWLACRLFLSIDDPVHVAKFADPFNDIASGIISIPIDLPGTPFNRGIKASNVVRQELKTIIKQRKLDLSDNKASPTQDILSHMLLTPDEDGRYMNELDIADKILGLLIGGHDTASAACTFVVKFLAELPHIYDGVYKEQMEIAKSKKEGERLNWEDIQKMKYSWNVACEVMRLAPPLQGAFREALSDFMYAGFQIPKGWKLYWSANSTHRNPECFPEPEKFDPARFDGSGPAPYTYVPFGGGPRMCPGKEYARLEILVFMHNIVKRFKWEKLIPDETIVVNPMPTPAKGLPVRLRPHSKPVTVSA" }, { "InterPro": [ { "InterPro-ID": "IPR009351", "InterPro-Name": "AlkZ-like", "InterPro-Type": "FAMILY", "Beg": 30, "End": 359 } ], "response#1": "MKASWRQVFAWRMQRQFLEPRTQPSASDVVGRLCGVQAQVWSVAELNVALRQAAPDRESVNREVADLSLMKTWAMRGTLHLLRPSEAGPYLSLMANTGSWLKPSWTRASGVTPRQVDELTEEVAGILDGVVLTRDELVTRLVADKRFVSMEERLRSGWGSVLKPLAWRGVLCHGPNRGNKITFTLPASQFGADWGKMPEPDEAAPTVIKAYLGAYGPATIETFDRWLSLNSTSKPKLRKWFGDMGDELTEVDVEGRKAFVLTEHAEELAATAPCTGIRLLGGFDQYLLGPGTKDEVVLAPEHRSAVSRAAGWISPVVVKDGRVVGVWEIVDQELVVTPFPDTERLPVKAVEKEAAHVARASGVSRLPVRIV", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to AlkZ-like that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MKASWRQVFAWRMQRQFLEPRTQPSASDVVGRLCGVQAQVWSVAELNVALRQAAPDRESVNREVADLSLMKTWAMRGTLHLLRPSEAGPYLSLMANTGSWLKPSWTRASGVTPRQVDELTEEVAGILDGVVLTRDELVTRLVADKRFVSMEERLRSGWGSVLKPLAWRGVLCHGPNRGNKITFTLPASQFGADWGKMPEPDEAAPTVIKAYLGAYGPATIETFDRWLSLNSTSKPKLRKWFGDMGDELTEVDVEGRKAFVLTEHAEELAATAPCTGIRLLGGFDQYLLGPGTKDEVVLAPEHRSAVSRAAGWISPVVVKDGRVVGVWEIVDQELVVTPFPDTERLPVKAVEKEAAHVARASGVSRLPVRIV" }, { "InterPro": [ { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 40, "End": 487 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 441, "End": 450 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 311, "End": 328 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 364, "End": 375 }, { "InterPro-ID": "IPR017972", "InterPro-Name": "Cyt_P450_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 443, "End": 452 }, { "InterPro-ID": "IPR036396", "InterPro-Name": "Cyt_P450_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 32, "End": 500 }, { "InterPro-ID": "IPR036396", "InterPro-Name": "Cyt_P450_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 38, "End": 503 }, { "InterPro-ID": "IPR052306", "InterPro-Name": "CYP450_71D", "InterPro-Type": "FAMILY", "Beg": 63, "End": 507 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 68, "End": 87 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 440, "End": 450 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 320, "End": 346 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 92, "End": 113 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 404, "End": 428 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 300, "End": 317 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 363, "End": 381 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 450, "End": 473 } ], "response#1": "MATPQFSCLLPAFFLLVVFLFLLIKELRRYKSPKTTQKLPPGPPMLPIIGNLHQMASSLPHQNLKKLADKYGPLMHLKLGEISAVAVSSPRLAKEVLQTRGLAFADRPQSVVAKLMLHNCLGVTFSRYGDYWRQLRQIFAMELLSSKSVQSFSTIMEDELFAMVKSIESEAGRPIILADKLISYLYATLSRATLGRVCKGKETLIEVTGETLALSGAQSLEDIFPSVKIFAYLNPLRPKVRKLFNRIDGVLEDIINQQEKKLLSARVDNDQLQPEENDMLSVLLKLRNGKDSKVQVTNNDIKAIIFELFLAGTVGSSTTVEWAMSEMMKNPKVMEKAQHEVREVLKGKKRICQSDIQKLSYLKLVVKETLRLHPPAPLLFPRECRGQCEVDGYTIPAKAMVMVNCWALGRDPEHWIEADKFEPERFKNSSIDFIGNHFEYIPFGAGRRICPGISFGATNVELLLAALLYHFDWELAGGMHPKDLDMLELFGPGCTRKNPLSVIPSICIPSHDDN", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Cyt_P450, Cyt_P450, Cyt_P450, Cyt_P450, CYP450_71D, Cyt_P450_E_grp-I, Cyt_P450_E_grp-I, Cyt_P450_E_grp-I, Cyt_P450_E_grp-I, Cyt_P450_E_grp-I, Cyt_P450_E_grp-I, Cyt_P450_E_grp-I, Cyt_P450_E_grp-I that shares evolutionary origin and functional similarity; 2. The protein should be classified within Cyt_P450_sf, Cyt_P450_sf sharing conserved structural features; 3. The protein should contain Cyt_P450_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MATPQFSCLLPAFFLLVVFLFLLIKELRRYKSPKTTQKLPPGPPMLPIIGNLHQMASSLPHQNLKKLADKYGPLMHLKLGEISAVAVSSPRLAKEVLQTRGLAFADRPQSVVAKLMLHNCLGVTFSRYGDYWRQLRQIFAMELLSSKSVQSFSTIMEDELFAMVKSIESEAGRPIILADKLISYLYATLSRATLGRVCKGKETLIEVTGETLALSGAQSLEDIFPSVKIFAYLNPLRPKVRKLFNRIDGVLEDIINQQEKKLLSARVDNDQLQPEENDMLSVLLKLRNGKDSKVQVTNNDIKAIIFELFLAGTVGSSTTVEWAMSEMMKNPKVMEKAQHEVREVLKGKKRICQSDIQKLSYLKLVVKETLRLHPPAPLLFPRECRGQCEVDGYTIPAKAMVMVNCWALGRDPEHWIEADKFEPERFKNSSIDFIGNHFEYIPFGAGRRICPGISFGATNVELLLAALLYHFDWELAGGMHPKDLDMLELFGPGCTRKNPLSVIPSICIPSHDDN" }, { "InterPro": [ { "InterPro-ID": "IPR047109", "InterPro-Name": "CAD-like", "InterPro-Type": "FAMILY", "Beg": 16, "End": 355 }, { "InterPro-ID": "IPR036291", "InterPro-Name": "NAD(P)-bd_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 161, "End": 324 }, { "InterPro-ID": "IPR002328", "InterPro-Name": "ADH_Zn_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 72, "End": 86 }, { "InterPro-ID": "IPR047109", "InterPro-Name": "CAD-like", "InterPro-Type": "FAMILY", "Beg": 12, "End": 359 }, { "InterPro-ID": "IPR011032", "InterPro-Name": "GroES-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 23, "End": 187 }, { "InterPro-ID": "IPR013149", "InterPro-Name": "ADH-like_C", "InterPro-Type": "DOMAIN", "Beg": 196, "End": 320 }, { "InterPro-ID": "IPR020843", "InterPro-Name": "PKS_ER", "InterPro-Type": "DOMAIN", "Beg": 24, "End": 343 }, { "InterPro-ID": "IPR013154", "InterPro-Name": "ADH-like_N", "InterPro-Type": "DOMAIN", "Beg": 38, "End": 156 } ], "response#1": "MAGESTQVDLSVKAIGWGAKDASGILHPIKFSRRTPGERDVKIRVLYCGVCNFDMEMVRNKWGFTRYPYVFGHETAGEVVEVGSKVQKFKVGDKVAVGCMVGSCGKCYNCENGMENYCPEPNMADGSVYREQGERSYGGCSNVMVVDEKFVLRWPENLPQDTGVPLLCAGVVVYSPMKYMGLDKPGKHIGVFGLGGLGSVAVKFIKAFGGKATVISTSRRKEKEAIEEHGADAFVVNSDTEQLQALAGTMDGVVDTTPGGRTPMSLMLNLLKFDGSLILVGAPETLFELPVQPLILGRRKIIGSSTGGLKEYQEMLDFAAKHNILCDTEVIGIDYLSTAMERIKNLDVKYRFAIDIGNTLKYEE", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more ADH-like_C, PKS_ER, ADH-like_N that are essential for its biological function; 2. The protein should belong to CAD-like, CAD-like that shares evolutionary origin and functional similarity; 3. The protein should be classified within NAD(P)-bd_dom_sf, GroES-like_sf sharing conserved structural features; 4. The protein should contain ADH_Zn_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MAGESTQVDLSVKAIGWGAKDASGILHPIKFSRRTPGERDVKIRVLYCGVCNFDMEMVRNKWGFTRYPYVFGHETAGEVVEVGSKVQKFKVGDKVAVGCMVGSCGKCYNCENGMENYCPEPNMADGSVYREQGERSYGGCSNVMVVDEKFVLRWPENLPQDTGVPLLCAGVVVYSPMKYMGLDKPGKHIGVFGLGGLGSVAVKFIKAFGGKATVISTSRRKEKEAIEEHGADAFVVNSDTEQLQALAGTMDGVVDTTPGGRTPMSLMLNLLKFDGSLILVGAPETLFELPVQPLILGRRKIIGSSTGGLKEYQEMLDFAAKHNILCDTEVIGIDYLSTAMERIKNLDVKYRFAIDIGNTLKYEE" }, { "InterPro": [ { "InterPro-ID": "IPR016461", "InterPro-Name": "COMT-like", "InterPro-Type": "FAMILY", "Beg": 1, "End": 351 }, { "InterPro-ID": "IPR036390", "InterPro-Name": "WH_DNA-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 4, "End": 105 }, { "InterPro-ID": "IPR036388", "InterPro-Name": "WH-like_DNA-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1, "End": 102 }, { "InterPro-ID": "IPR001077", "InterPro-Name": "O_MeTrfase_dom", "InterPro-Type": "DOMAIN", "Beg": 127, "End": 332 }, { "InterPro-ID": "IPR029063", "InterPro-Name": "SAM-dependent_MTases_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 103, "End": 351 }, { "InterPro-ID": "IPR016461", "InterPro-Name": "COMT-like", "InterPro-Type": "FAMILY", "Beg": 11, "End": 332 }, { "InterPro-ID": "IPR016461", "InterPro-Name": "COMT-like", "InterPro-Type": "FAMILY", "Beg": 11, "End": 351 }, { "InterPro-ID": "IPR029063", "InterPro-Name": "SAM-dependent_MTases_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 108, "End": 339 }, { "InterPro-ID": "IPR012967", "InterPro-Name": "Plant_O-MeTrfase_dimerisation", "InterPro-Type": "DOMAIN", "Beg": 4, "End": 105 } ], "response#1": "MGNEEAFTFALAMATGSFANMVLRAVVELDVFEIMKRAGPGTHLSAAEIAAHLPTKNPDANAMLDRMLRVLAGYEVLSCSNRSLPNGQVERLYGLSPVSQFFTKSEDGASLAPLCLLNQDKVYWESWYHLKDAVLDGGIAFNRAHNLTLYEYAGIDDRFNKVFNDGMSGCSTTIMKKMVENYKGFEGVSTLVDVAGGIGKNLNMIISKYPTIKGINFDLPHVIKDAPRCRGVENIGGDMFISVPQGDAIFIKWICCDWNDEHCLKFLKNCYAALPDHGKVILYEFIFPKASETSYAARVILNIDAVTLATVVGGRIRTEAEFEALAKGAGFEGFKMAYSTSEVDAVMEFLKKK", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more O_MeTrfase_dom, Plant_O-MeTrfase_dimerisation that are essential for its biological function; 2. The protein should belong to COMT-like, COMT-like, COMT-like that shares evolutionary origin and functional similarity; 3. The protein should be classified within WH_DNA-bd_sf, WH-like_DNA-bd_sf, SAM-dependent_MTases_sf, SAM-dependent_MTases_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MGNEEAFTFALAMATGSFANMVLRAVVELDVFEIMKRAGPGTHLSAAEIAAHLPTKNPDANAMLDRMLRVLAGYEVLSCSNRSLPNGQVERLYGLSPVSQFFTKSEDGASLAPLCLLNQDKVYWESWYHLKDAVLDGGIAFNRAHNLTLYEYAGIDDRFNKVFNDGMSGCSTTIMKKMVENYKGFEGVSTLVDVAGGIGKNLNMIISKYPTIKGINFDLPHVIKDAPRCRGVENIGGDMFISVPQGDAIFIKWICCDWNDEHCLKFLKNCYAALPDHGKVILYEFIFPKASETSYAARVILNIDAVTLATVVGGRIRTEAEFEALAKGAGFEGFKMAYSTSEVDAVMEFLKKK" }, { "InterPro": [ { "InterPro-ID": "IPR010636", "InterPro-Name": "Cerato-ulmin_hydrophobin", "InterPro-Type": "FAMILY", "Beg": 2, "End": 101 }, { "InterPro-ID": "IPR010636", "InterPro-Name": "Cerato-ulmin_hydrophobin", "InterPro-Type": "FAMILY", "Beg": 38, "End": 100 }, { "InterPro-ID": "IPR036686", "InterPro-Name": "Hydrophobin_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 31, "End": 104 }, { "InterPro-ID": "IPR010636", "InterPro-Name": "Cerato-ulmin_hydrophobin", "InterPro-Type": "FAMILY", "Beg": 36, "End": 101 }, { "InterPro-ID": "IPR036686", "InterPro-Name": "Hydrophobin_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 36, "End": 103 } ], "response#1": "MQFFTVATLFLATAFAAPSVDTNGNGIAPRLAANFCPPGLLYSNPQCCQIDVLGVADLDCVSPPSGPSKCKTFAGICDKIGRQPKCCVVPVAGQALLCTDPVGANN", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Cerato-ulmin_hydrophobin, Cerato-ulmin_hydrophobin, Cerato-ulmin_hydrophobin that shares evolutionary origin and functional similarity; 2. The protein should be classified within Hydrophobin_sf, Hydrophobin_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MQFFTVATLFLATAFAAPSVDTNGNGIAPRLAANFCPPGLLYSNPQCCQIDVLGVADLDCVSPPSGPSKCKTFAGICDKIGRQPKCCVVPVAGQALLCTDPVGANN" }, { "InterPro": [ { "InterPro-ID": "IPR004792", "InterPro-Name": "BaiN-like", "InterPro-Type": "FAMILY", "Beg": 6, "End": 387 }, { "InterPro-ID": "IPR023166", "InterPro-Name": "BaiN-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 261, "End": 317 }, { "InterPro-ID": "IPR004792", "InterPro-Name": "BaiN-like", "InterPro-Type": "FAMILY", "Beg": 4, "End": 387 }, { "InterPro-ID": "IPR036188", "InterPro-Name": "FAD/NAD-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 5, "End": 386 }, { "InterPro-ID": "IPR055178", "InterPro-Name": "BaiN-like_dom", "InterPro-Type": "DOMAIN", "Beg": 192, "End": 334 }, { "InterPro-ID": "IPR036188", "InterPro-Name": "FAD/NAD-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1, "End": 386 } ], "response#1": "MNHFDTIIIGGGPAGMMATISSSFYGQKTLLLEKNKRLGKKLAGTGGGRCNVTNNGNLDDLMAGIPGNGRFLYSVFSQFDNHDIINFFTENGVKLKVEDHGRVFPVTDKSRTIIEALEKKIAELGGTVITNTEIVSVKKTDELFTVRSSDQAWTCQKLIVTTGGKSYPSTGSTGFGHDIARHFKHTVTDLEAAESPLLTDFPHKALQGISLDDVTLSYGKHIITHDLLFTHFGLSGPAALRLSSFVKGGETIYLDVLPQMSQQDLADFLEEHREKSLKNCLKILLPERIADFFTQPFPEKVKQLNLSEKEALIKQIKELPISVTGKMSLAKSFVTKGGVSLKEINPKTLESKLVPGLHFAGEVLDINAHTGGFNITSALCTGWVAGSLHYD", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more BaiN-like_dom that are essential for its biological function; 2. The protein should belong to BaiN-like, BaiN-like that shares evolutionary origin and functional similarity; 3. The protein should be classified within BaiN-like_dom_sf, FAD/NAD-bd_sf, FAD/NAD-bd_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MNHFDTIIIGGGPAGMMATISSSFYGQKTLLLEKNKRLGKKLAGTGGGRCNVTNNGNLDDLMAGIPGNGRFLYSVFSQFDNHDIINFFTENGVKLKVEDHGRVFPVTDKSRTIIEALEKKIAELGGTVITNTEIVSVKKTDELFTVRSSDQAWTCQKLIVTTGGKSYPSTGSTGFGHDIARHFKHTVTDLEAAESPLLTDFPHKALQGISLDDVTLSYGKHIITHDLLFTHFGLSGPAALRLSSFVKGGETIYLDVLPQMSQQDLADFLEEHREKSLKNCLKILLPERIADFFTQPFPEKVKQLNLSEKEALIKQIKELPISVTGKMSLAKSFVTKGGVSLKEINPKTLESKLVPGLHFAGEVLDINAHTGGFNITSALCTGWVAGSLHYD" }, { "InterPro": [ { "InterPro-ID": "IPR010636", "InterPro-Name": "Cerato-ulmin_hydrophobin", "InterPro-Type": "FAMILY", "Beg": 29, "End": 93 }, { "InterPro-ID": "IPR010636", "InterPro-Name": "Cerato-ulmin_hydrophobin", "InterPro-Type": "FAMILY", "Beg": 10, "End": 94 }, { "InterPro-ID": "IPR010636", "InterPro-Name": "Cerato-ulmin_hydrophobin", "InterPro-Type": "FAMILY", "Beg": 30, "End": 94 }, { "InterPro-ID": "IPR036686", "InterPro-Name": "Hydrophobin_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 17, "End": 97 }, { "InterPro-ID": "IPR036686", "InterPro-Name": "Hydrophobin_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 29, "End": 96 } ], "response#1": "MKFFAAAALFIAGVLAAPSPNAANSVTPLCNPGLYSNAQCCAVDVLGVADLNCATPPGVVNNAAEFQAACAKIGQEARCCVLPVLGQDVLCETPLGL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Cerato-ulmin_hydrophobin, Cerato-ulmin_hydrophobin, Cerato-ulmin_hydrophobin that shares evolutionary origin and functional similarity; 2. The protein should be classified within Hydrophobin_sf, Hydrophobin_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MKFFAAAALFIAGVLAAPSPNAANSVTPLCNPGLYSNAQCCAVDVLGVADLNCATPPGVVNNAAEFQAACAKIGQEARCCVLPVLGQDVLCETPLGL" }, { "InterPro": [ { "InterPro-ID": "IPR029063", "InterPro-Name": "SAM-dependent_MTases_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 7, "End": 273 }, { "InterPro-ID": "IPR041698", "InterPro-Name": "Methyltransf_25", "InterPro-Type": "DOMAIN", "Beg": 58, "End": 170 }, { "InterPro-ID": "IPR029063", "InterPro-Name": "SAM-dependent_MTases_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 5, "End": 198 } ], "response#1": "MAVVERDSDYYDSSYLADYYESLWTDHAALEDIAVYWAFFKERVLLSQSRVDSKFFLLDVGTGTGRVLHSLIDKAVNDADMSLDAMQFVGMDKSPFMLEQAQRAKQLPQEVRASWFVGTATALEDIASLADPHGKANLLIFAFSGINHLHQPGEIDQFFLSARRVLLPGGLALVSVCAPLLDIEGGDSVPNPYGQVKEVKSKRLEGILYREWETGQKIEGHLFTNSLKTDVVQVSQDGSERVIERNIHNIPLTLLTRDGLRRSAAAAKLEIIEERCIRDEVIFALRAVG", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Methyltransf_25 that are essential for its biological function; 2. The protein should be classified within SAM-dependent_MTases_sf, SAM-dependent_MTases_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MAVVERDSDYYDSSYLADYYESLWTDHAALEDIAVYWAFFKERVLLSQSRVDSKFFLLDVGTGTGRVLHSLIDKAVNDADMSLDAMQFVGMDKSPFMLEQAQRAKQLPQEVRASWFVGTATALEDIASLADPHGKANLLIFAFSGINHLHQPGEIDQFFLSARRVLLPGGLALVSVCAPLLDIEGGDSVPNPYGQVKEVKSKRLEGILYREWETGQKIEGHLFTNSLKTDVVQVSQDGSERVIERNIHNIPLTLLTRDGLRRSAAAAKLEIIEERCIRDEVIFALRAVG" }, { "InterPro": [ { "InterPro-ID": "IPR036396", "InterPro-Name": "Cyt_P450_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 44, "End": 501 }, { "InterPro-ID": "IPR036396", "InterPro-Name": "Cyt_P450_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 28, "End": 501 }, { "InterPro-ID": "IPR017972", "InterPro-Name": "Cyt_P450_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 441, "End": 450 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 438, "End": 448 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 318, "End": 344 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 448, "End": 471 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 71, "End": 90 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 95, "End": 116 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 298, "End": 315 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 402, "End": 426 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 361, "End": 379 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 362, "End": 373 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 439, "End": 448 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 448, "End": 459 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 309, "End": 326 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 44, "End": 494 } ], "response#1": "MDSPTLLLFIFASIFYFITFQIVKLGFNVVMTSKKTKRRRLPLPPGPKPLPIIGNVLELGPKPHRSFANLAKVHGPLMSLRLGSVTTIIVSSSDVAKEMFLKNDQPLSSNRTIPNSVTAGDHHLLTMSWLPVSPKWRSFRKITTFHLLSPQRLDSCCSLRQAKVQQLFEYVLECSRTGQTVDIGKAAFTTSLNLLSKLFFSLELAHHRSSKSQEFKDLIWDIMEDIGKPNYADYFPCLKYFDPCGIRRRLANSFEKLIEVFQGIIRQRLSLSSGSDTHNDVLDVLLQLYKQKELSMDEINHLLVDIFDAGTDTTSSTFEWAMAELIKSPKTMEKAQAEIKLVLGKESHIQESDIPKLPYLRAIIKETLRLHPPTVFLLPRKAETDVELYGYTVPKNAQILVNLWALGRDPKVWENPDVFLPERFLTCDIDVKGRDFGLLPFGAGRRICPGMNLAYRMLTLMLATLLQSFDWKLPNELNPRNLDMDEKFGIALQKTKPLEIIPVCKD", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Cyt_P450_E_grp-I, Cyt_P450_E_grp-I, Cyt_P450_E_grp-I, Cyt_P450_E_grp-I, Cyt_P450_E_grp-I, Cyt_P450_E_grp-I, Cyt_P450_E_grp-I, Cyt_P450_E_grp-I, Cyt_P450, Cyt_P450, Cyt_P450, Cyt_P450, Cyt_P450 that shares evolutionary origin and functional similarity; 2. The protein should be classified within Cyt_P450_sf, Cyt_P450_sf sharing conserved structural features; 3. The protein should contain Cyt_P450_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MDSPTLLLFIFASIFYFITFQIVKLGFNVVMTSKKTKRRRLPLPPGPKPLPIIGNVLELGPKPHRSFANLAKVHGPLMSLRLGSVTTIIVSSSDVAKEMFLKNDQPLSSNRTIPNSVTAGDHHLLTMSWLPVSPKWRSFRKITTFHLLSPQRLDSCCSLRQAKVQQLFEYVLECSRTGQTVDIGKAAFTTSLNLLSKLFFSLELAHHRSSKSQEFKDLIWDIMEDIGKPNYADYFPCLKYFDPCGIRRRLANSFEKLIEVFQGIIRQRLSLSSGSDTHNDVLDVLLQLYKQKELSMDEINHLLVDIFDAGTDTTSSTFEWAMAELIKSPKTMEKAQAEIKLVLGKESHIQESDIPKLPYLRAIIKETLRLHPPTVFLLPRKAETDVELYGYTVPKNAQILVNLWALGRDPKVWENPDVFLPERFLTCDIDVKGRDFGLLPFGAGRRICPGMNLAYRMLTLMLATLLQSFDWKLPNELNPRNLDMDEKFGIALQKTKPLEIIPVCKD" }, { "InterPro": [ { "InterPro-ID": "IPR010636", "InterPro-Name": "Cerato-ulmin_hydrophobin", "InterPro-Type": "FAMILY", "Beg": 27, "End": 88 }, { "InterPro-ID": "IPR036686", "InterPro-Name": "Hydrophobin_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 13, "End": 88 }, { "InterPro-ID": "IPR010636", "InterPro-Name": "Cerato-ulmin_hydrophobin", "InterPro-Type": "FAMILY", "Beg": 2, "End": 88 }, { "InterPro-ID": "IPR036686", "InterPro-Name": "Hydrophobin_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 30, "End": 88 }, { "InterPro-ID": "IPR010636", "InterPro-Name": "Cerato-ulmin_hydrophobin", "InterPro-Type": "FAMILY", "Beg": 26, "End": 87 } ], "response#1": "MQFLVLALASLAAAAPSIKLRAPSDVCPALDTPLCCQADVLGVLDLTCEAPSDDTSVSNFEAACATTGLTARCCTLPLLGEALLCTTP", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Cerato-ulmin_hydrophobin, Cerato-ulmin_hydrophobin, Cerato-ulmin_hydrophobin that shares evolutionary origin and functional similarity; 2. The protein should be classified within Hydrophobin_sf, Hydrophobin_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MQFLVLALASLAAAAPSIKLRAPSDVCPALDTPLCCQADVLGVLDLTCEAPSDDTSVSNFEAACATTGLTARCCTLPLLGEALLCTTP" }, { "InterPro": [ { "InterPro-ID": "IPR019778", "InterPro-Name": "Hydrophobin_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 78, "End": 89 }, { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 26, "End": 101 }, { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 26, "End": 104 } ], "response#1": "MFSRVFAVASLAALALAGPLSVRDQCNTGTIQCCQQVQQASYYQSAFQEIGLGELLAGVTGQIGTQCSPISVVGASNGAQCNAQTVCCTNTQFNGLINIGCMPINVNA", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Hydrophobin, Hydrophobin that shares evolutionary origin and functional similarity; 2. The protein should contain Hydrophobin_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MFSRVFAVASLAALALAGPLSVRDQCNTGTIQCCQQVQQASYYQSAFQEIGLGELLAGVTGQIGTQCSPISVVGASNGAQCNAQTVCCTNTQFNGLINIGCMPINVNA" }, { "InterPro": [ { "InterPro-ID": "IPR036388", "InterPro-Name": "WH-like_DNA-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 2, "End": 112 }, { "InterPro-ID": "IPR016461", "InterPro-Name": "COMT-like", "InterPro-Type": "FAMILY", "Beg": 19, "End": 342 }, { "InterPro-ID": "IPR012967", "InterPro-Name": "Plant_O-MeTrfase_dimerisation", "InterPro-Type": "DOMAIN", "Beg": 13, "End": 114 }, { "InterPro-ID": "IPR036390", "InterPro-Name": "WH_DNA-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 13, "End": 116 }, { "InterPro-ID": "IPR029063", "InterPro-Name": "SAM-dependent_MTases_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 113, "End": 360 }, { "InterPro-ID": "IPR016461", "InterPro-Name": "COMT-like", "InterPro-Type": "FAMILY", "Beg": 1, "End": 360 }, { "InterPro-ID": "IPR001077", "InterPro-Name": "O_MeTrfase_dom", "InterPro-Type": "DOMAIN", "Beg": 137, "End": 342 }, { "InterPro-ID": "IPR016461", "InterPro-Name": "COMT-like", "InterPro-Type": "FAMILY", "Beg": 21, "End": 360 }, { "InterPro-ID": "IPR029063", "InterPro-Name": "SAM-dependent_MTases_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 118, "End": 357 } ], "response#1": "MGSTSAERTQMGEDEACSYAMTITSGSVPPMVLKAVIELDVLEIIKRAGPGAHLSPAEIAAQLPATNPDAATMLDRMLRLLASYSILSYSLRTLPDGRVERLYGLAPVCQFLTKNEDGVTLGALSLMNQDKVLMESWYHLKDAVLDGGIPFNKAYGMTAFEYHGTDPRFNKIFNNGMSNHSTITMKRILENYKGFEGLSTLVDVGGGTGATLNMIISKHPAIKGINFDLPHVIEDAPTYNGVEHVGGDMFVSVPKGDAIFMKWICHDWSDEHCLNFLKNCYAALPDHGKVIVCEYILPVAPETSHAARTVFHVDAIMLAHNPGGKERTEQEFEALAKGAGFEGFRVACSAYGTKVMEFLKKA", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Plant_O-MeTrfase_dimerisation, O_MeTrfase_dom that are essential for its biological function; 2. The protein should belong to COMT-like, COMT-like, COMT-like that shares evolutionary origin and functional similarity; 3. The protein should be classified within WH-like_DNA-bd_sf, WH_DNA-bd_sf, SAM-dependent_MTases_sf, SAM-dependent_MTases_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MGSTSAERTQMGEDEACSYAMTITSGSVPPMVLKAVIELDVLEIIKRAGPGAHLSPAEIAAQLPATNPDAATMLDRMLRLLASYSILSYSLRTLPDGRVERLYGLAPVCQFLTKNEDGVTLGALSLMNQDKVLMESWYHLKDAVLDGGIPFNKAYGMTAFEYHGTDPRFNKIFNNGMSNHSTITMKRILENYKGFEGLSTLVDVGGGTGATLNMIISKHPAIKGINFDLPHVIEDAPTYNGVEHVGGDMFVSVPKGDAIFMKWICHDWSDEHCLNFLKNCYAALPDHGKVIVCEYILPVAPETSHAARTVFHVDAIMLAHNPGGKERTEQEFEALAKGAGFEGFRVACSAYGTKVMEFLKKA" }, { "InterPro": [ { "InterPro-ID": "IPR036390", "InterPro-Name": "WH_DNA-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 35, "End": 141 }, { "InterPro-ID": "IPR016461", "InterPro-Name": "COMT-like", "InterPro-Type": "FAMILY", "Beg": 22, "End": 386 }, { "InterPro-ID": "IPR036388", "InterPro-Name": "WH-like_DNA-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 23, "End": 138 }, { "InterPro-ID": "IPR001077", "InterPro-Name": "O_MeTrfase_dom", "InterPro-Type": "DOMAIN", "Beg": 163, "End": 368 }, { "InterPro-ID": "IPR029063", "InterPro-Name": "SAM-dependent_MTases_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 139, "End": 386 }, { "InterPro-ID": "IPR016461", "InterPro-Name": "COMT-like", "InterPro-Type": "FAMILY", "Beg": 45, "End": 386 }, { "InterPro-ID": "IPR016461", "InterPro-Name": "COMT-like", "InterPro-Type": "FAMILY", "Beg": 43, "End": 367 }, { "InterPro-ID": "IPR029063", "InterPro-Name": "SAM-dependent_MTases_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 144, "End": 384 }, { "InterPro-ID": "IPR012967", "InterPro-Name": "Plant_O-MeTrfase_dimerisation", "InterPro-Type": "DOMAIN", "Beg": 37, "End": 140 } ], "response#1": "MAEIPTSSNPSDDPETQKLNGNEEDYDHHHDEDPESDDENYEYALQIAEMLPFPMVMQTAIELDLLGIIATAGPDRQLSAAEIAAALPAAGNPDAPAMLDRMLYLLATYSVVTCTAVDGGASGGVVRKYGLAPVAKYFVSNEDGVSLGALISLNQGQAFLASWSKLKEAVLEGGIPFNKVHGMDVFHYQGTDPRFNKIFNKAMYGQSTYIIKKIVRRYKGFENIQRLVDVGGGLGHTLRVITSNYPSIKGINFDLPHVIQHAPTIPGVEHVGGDMFESIPNGDAIFMKCILHDWSDEHCLKTLKNCYKALPRKGKVIVVQMNMIEEPQTTPLAKAISQLDVCLMTQSPGGKERTRREFQTLAEAAGFAEFNPVCHVAGFWVMEFLK", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more O_MeTrfase_dom, Plant_O-MeTrfase_dimerisation that are essential for its biological function; 2. The protein should belong to COMT-like, COMT-like, COMT-like that shares evolutionary origin and functional similarity; 3. The protein should be classified within WH_DNA-bd_sf, WH-like_DNA-bd_sf, SAM-dependent_MTases_sf, SAM-dependent_MTases_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MAEIPTSSNPSDDPETQKLNGNEEDYDHHHDEDPESDDENYEYALQIAEMLPFPMVMQTAIELDLLGIIATAGPDRQLSAAEIAAALPAAGNPDAPAMLDRMLYLLATYSVVTCTAVDGGASGGVVRKYGLAPVAKYFVSNEDGVSLGALISLNQGQAFLASWSKLKEAVLEGGIPFNKVHGMDVFHYQGTDPRFNKIFNKAMYGQSTYIIKKIVRRYKGFENIQRLVDVGGGLGHTLRVITSNYPSIKGINFDLPHVIQHAPTIPGVEHVGGDMFESIPNGDAIFMKCILHDWSDEHCLKTLKNCYKALPRKGKVIVVQMNMIEEPQTTPLAKAISQLDVCLMTQSPGGKERTRREFQTLAEAAGFAEFNPVCHVAGFWVMEFLK" }, { "InterPro": [ { "InterPro-ID": "IPR011006", "InterPro-Name": "CheY-like_superfamily", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 531, "End": 690 }, { "InterPro-ID": "IPR001789", "InterPro-Name": "Sig_transdc_resp-reg_receiver", "InterPro-Type": "DOMAIN", "Beg": 535, "End": 611 }, { "InterPro-ID": "IPR001789", "InterPro-Name": "Sig_transdc_resp-reg_receiver", "InterPro-Type": "DOMAIN", "Beg": 533, "End": 687 }, { "InterPro-ID": "IPR001789", "InterPro-Name": "Sig_transdc_resp-reg_receiver", "InterPro-Type": "DOMAIN", "Beg": 534, "End": 691 } ], "response#1": "MSNIKTRLQKARSKFSRRNSEASTRARSIASSAGSDRHGHAPPPPLSSPLRKSVSLPRLAEPAASGKALGLGAHGDDDDDEQLLVVGRAATESQADAEASTGSLNTSRDGRSSCTQASTAPSSSHDARKPSADVPIVCPQVTLDAPTPVHPGAPPAELDRPALPDSLSSTPSSVPATTTTTATTTATTTSLPPSPARVHRHAAITTAHAADARLATNLPGPDDSQAATPSGPPPSTARSAAMLHRKIWVKRPNASATLVQIREDDLVDDVRDMILKKYANSLGRSFDAPDVTLRIVPRDSQRAGERTLGPEEDMCRTIDAYFPGGQTVHEALIIDVPSRRTPKPSPRVPPYYHHEDGIHPQTEYFPPMSAMTPSPATMSTSLQHPHDNRIPVPQLHSISVLNTGQLPNLPSPGSTRRGPMHPHRPKYNRTHTASPTTLGGGIPSSATSVRPANRPRHDSSASEAKNSAASNNPIPTPPIPADPTPHQQTLQTSTPPTPRISSPQLNTKKKRRKAPVEPPALPAGLLDGSVPPINVLIVEDNIINLRVLGAFMQRLKVRWQRAMNGKEAVTKWKAGGFHLVLMDIQLPVMNGLEATKEIRRLERVNGIGVFSSGSSEAPNTRLGSDSKSQDELREDDKLGDKGMFKSPVIIVALTASSLQSDRHEALAAGCNDFLTKPVNFVWLERKVKEWGCMQALIDFDGWRKWKDFADKSENNDTTSKLSGSFTSVAPNKKAANTSPTTATSETNGVKKDAETERKNKRKSLGVVPQPVLREEAEPQPAEVDSGDN", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Sig_transdc_resp-reg_receiver, Sig_transdc_resp-reg_receiver, Sig_transdc_resp-reg_receiver that are essential for its biological function; 2. The protein should be classified within CheY-like_superfamily sharing conserved structural features. The designed protein sequence is ", "reference": "MSNIKTRLQKARSKFSRRNSEASTRARSIASSAGSDRHGHAPPPPLSSPLRKSVSLPRLAEPAASGKALGLGAHGDDDDDEQLLVVGRAATESQADAEASTGSLNTSRDGRSSCTQASTAPSSSHDARKPSADVPIVCPQVTLDAPTPVHPGAPPAELDRPALPDSLSSTPSSVPATTTTTATTTATTTSLPPSPARVHRHAAITTAHAADARLATNLPGPDDSQAATPSGPPPSTARSAAMLHRKIWVKRPNASATLVQIREDDLVDDVRDMILKKYANSLGRSFDAPDVTLRIVPRDSQRAGERTLGPEEDMCRTIDAYFPGGQTVHEALIIDVPSRRTPKPSPRVPPYYHHEDGIHPQTEYFPPMSAMTPSPATMSTSLQHPHDNRIPVPQLHSISVLNTGQLPNLPSPGSTRRGPMHPHRPKYNRTHTASPTTLGGGIPSSATSVRPANRPRHDSSASEAKNSAASNNPIPTPPIPADPTPHQQTLQTSTPPTPRISSPQLNTKKKRRKAPVEPPALPAGLLDGSVPPINVLIVEDNIINLRVLGAFMQRLKVRWQRAMNGKEAVTKWKAGGFHLVLMDIQLPVMNGLEATKEIRRLERVNGIGVFSSGSSEAPNTRLGSDSKSQDELREDDKLGDKGMFKSPVIIVALTASSLQSDRHEALAAGCNDFLTKPVNFVWLERKVKEWGCMQALIDFDGWRKWKDFADKSENNDTTSKLSGSFTSVAPNKKAANTSPTTATSETNGVKKDAETERKNKRKSLGVVPQPVLREEAEPQPAEVDSGDN" }, { "InterPro": [ { "InterPro-ID": "IPR010636", "InterPro-Name": "Cerato-ulmin_hydrophobin", "InterPro-Type": "FAMILY", "Beg": 34, "End": 88 }, { "InterPro-ID": "IPR036686", "InterPro-Name": "Hydrophobin_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 28, "End": 89 }, { "InterPro-ID": "IPR036686", "InterPro-Name": "Hydrophobin_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 34, "End": 88 } ], "response#1": "MKLYIAAALLTLGLAAPITETESHSIASRGSFSCPGGLINSSPMCCSVNVLGLLALDCRNVGPDGCVGSSKPNCCTLGTAGQGLICNEM", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Cerato-ulmin_hydrophobin that shares evolutionary origin and functional similarity; 2. The protein should be classified within Hydrophobin_sf, Hydrophobin_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MKLYIAAALLTLGLAAPITETESHSIASRGSFSCPGGLINSSPMCCSVNVLGLLALDCRNVGPDGCVGSSKPNCCTLGTAGQGLICNEM" }, { "InterPro": [ { "InterPro-ID": "IPR000999", "InterPro-Name": "RNase_III_dom", "InterPro-Type": "DOMAIN", "Beg": 1671, "End": 1679 }, { "InterPro-ID": "IPR014720", "InterPro-Name": "dsRBD_dom", "InterPro-Type": "DOMAIN", "Beg": 1819, "End": 1882 }, { "InterPro-ID": "IPR048513", "InterPro-Name": "Dicer_PBD", "InterPro-Type": "DOMAIN", "Beg": 258, "End": 356 }, { "InterPro-ID": "IPR014001", "InterPro-Name": "Helicase_ATP-bd", "InterPro-Type": "DOMAIN", "Beg": 41, "End": 217 }, { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 29, "End": 253 }, { "InterPro-ID": "IPR000999", "InterPro-Name": "RNase_III_dom", "InterPro-Type": "DOMAIN", "Beg": 1651, "End": 1815 }, { "InterPro-ID": "IPR003100", "InterPro-Name": "PAZ_dom", "InterPro-Type": "DOMAIN", "Beg": 917, "End": 1054 }, { "InterPro-ID": "IPR044441", "InterPro-Name": "DICER_DSRM", "InterPro-Type": "DOMAIN", "Beg": 1799, "End": 1887 }, { "InterPro-ID": "IPR036389", "InterPro-Name": "RNase_III_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1621, "End": 1818 }, { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 83, "End": 559 }, { "InterPro-ID": "IPR003100", "InterPro-Name": "PAZ_dom", "InterPro-Type": "DOMAIN", "Beg": 883, "End": 1058 }, { "InterPro-ID": "IPR014001", "InterPro-Name": "Helicase_ATP-bd", "InterPro-Type": "DOMAIN", "Beg": 30, "End": 233 }, { "InterPro-ID": "IPR036389", "InterPro-Name": "RNase_III_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1635, "End": 1816 }, { "InterPro-ID": "IPR038248", "InterPro-Name": "Dicer_dimer_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 617, "End": 717 }, { "InterPro-ID": "IPR001650", "InterPro-Name": "Helicase_C-like", "InterPro-Type": "DOMAIN", "Beg": 425, "End": 594 }, { "InterPro-ID": "IPR005034", "InterPro-Name": "Dicer_dimerisation_dom", "InterPro-Type": "DOMAIN", "Beg": 622, "End": 714 }, { "InterPro-ID": "IPR000999", "InterPro-Name": "RNase_III_dom", "InterPro-Type": "DOMAIN", "Beg": 1650, "End": 1816 }, { "InterPro-ID": "IPR000999", "InterPro-Name": "RNase_III_dom", "InterPro-Type": "DOMAIN", "Beg": 1271, "End": 1571 }, { "InterPro-ID": "IPR001650", "InterPro-Name": "Helicase_C-like", "InterPro-Type": "DOMAIN", "Beg": 451, "End": 548 }, { "InterPro-ID": "IPR005034", "InterPro-Name": "Dicer_dimerisation_dom", "InterPro-Type": "DOMAIN", "Beg": 622, "End": 710 }, { "InterPro-ID": "IPR036389", "InterPro-Name": "RNase_III_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1263, "End": 1561 }, { "InterPro-ID": "IPR048512", "InterPro-Name": "Dicer_platform", "InterPro-Type": "DOMAIN", "Beg": 753, "End": 878 }, { "InterPro-ID": "IPR000999", "InterPro-Name": "RNase_III_dom", "InterPro-Type": "DOMAIN", "Beg": 1272, "End": 1352 }, { "InterPro-ID": "IPR014720", "InterPro-Name": "dsRBD_dom", "InterPro-Type": "DOMAIN", "Beg": 1818, "End": 1883 }, { "InterPro-ID": "IPR003100", "InterPro-Name": "PAZ_dom", "InterPro-Type": "DOMAIN", "Beg": 887, "End": 1034 }, { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 403, "End": 580 }, { "InterPro-ID": "IPR000999", "InterPro-Name": "RNase_III_dom", "InterPro-Type": "DOMAIN", "Beg": 1260, "End": 1338 }, { "InterPro-ID": "IPR000999", "InterPro-Name": "RNase_III_dom", "InterPro-Type": "DOMAIN", "Beg": 1635, "End": 1793 }, { "InterPro-ID": "IPR044441", "InterPro-Name": "DICER_DSRM", "InterPro-Type": "DOMAIN", "Beg": 1820, "End": 1882 }, { "InterPro-ID": "IPR011545", "InterPro-Name": "DEAD/DEAH_box_helicase_dom", "InterPro-Type": "DOMAIN", "Beg": 36, "End": 199 }, { "InterPro-ID": "IPR036085", "InterPro-Name": "PAZ_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 922, "End": 980 }, { "InterPro-ID": "IPR000999", "InterPro-Name": "RNase_III_dom", "InterPro-Type": "DOMAIN", "Beg": 1289, "End": 1359 }, { "InterPro-ID": "IPR000999", "InterPro-Name": "RNase_III_dom", "InterPro-Type": "DOMAIN", "Beg": 1671, "End": 1793 }, { "InterPro-ID": "IPR036389", "InterPro-Name": "RNase_III_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1269, "End": 1569 }, { "InterPro-ID": "IPR001650", "InterPro-Name": "Helicase_C-like", "InterPro-Type": "DOMAIN", "Beg": 491, "End": 545 } ], "response#1": "MAGLQLMTPASSPMGPFFGLPWQQEAIHDNIYTPRKYQVELLEAALDHNTIVCLNSGSGKTFIAVLLSKELSYQIRGDFSKNAKRTVFLVNSEKQVSQQVSAVRTHTDLKVGEYSDLQKTQCWAKEKWYQEFETRQVLVMTCHIFLNVLKSGNVSLSNINLLVFDECHLAIQDHPYREIMKICESCQPCPRILGLTASILNGKCDPRDLEEKIQKLEKILRSNAETATDLVVLDRYASQPCEIVLDCGPYVDRSGLFQRLLNELDEALNFLIDCNISTHSKERDSTIISKQILSDCRAVLLVLGPWCADKVAGMMVRELQKYIKHEQEELHRKFLLFTDTILRKIHALCEEHFSPASLDMKFVTPKVIKLLEILRKYKPYERQQFESVEWYNNRNQDNYVSWSDSEDDDDDEDEEIEEKEKTETSFPSPFTNILCGIIFVERRYTAVVLNRLIKEAGKQDPELAYISSNFITGHGIGKNQPRNKQMEVEFRKQEEVLRKFRAHETNLLIATSIVEEGVDIPKCNLVVRFDLPSEYRSYVQSKGRARAPISNYIMLADSDKIKTFEEDLKTYKAIEKILRNKCSKSIDCGNTESEPVVDDDEIFPPYVLRQDDGSPRVTINTAIGHINRYCARLPSDPFTHLAPKCKTREMSDGPYRSTLYLPINSPLRAPIVGPPMNCARLAERAVALICCKKLHEIGELDDHLMPVGKETVKYEEELDLHDEEETSVPGRPGSTKRRQCYPKAIPECLRNSYPKPGQPCYLYVIGMVLTTPLPDELNFRRRKLYPPEDTTRCFGILTAKPIPQIPHFPVYTRSGEVTISIELKKSGFTLNLEQLELITRLHQYIFSHILRLEKPALEFKPTVADCAYCVLPLNVVNDSGTLDIDFKFVEDIEKSEARTGIPNTQYSAESPFIFKLEDYQDAVIIPRYRNFDQPHRFYVADVYTDLTPLSKFPSPEYETFAEYYKTKYNLDLTNLNQPLLDVDHTSSRLNLLTPRHLNQKGKALPLSSAEKRKAKWESLQNKQILVPELCAIHPVPASLWRKAVCLPSILYRLHCLLTAEELRAQTAIDAGVGVKSLPEDFRYPNLDFGWKRSIDSKTFISSQSSSAVESEGDCRLNTTMVPDSATSSAANHVIYTQTNDQMSVNCTPLCQKSLSDLRGVCFSEDYKAINGVSCNGVTSDSEAESGVCFQKDERIACTQEIPEKSTSFHIQNLPKENQPILNECTLSKKFLDGNVSKPTSDECPSTCTSDMQYESGLSNGYSSKTLGPNPGLILQALTLSNASDGFNLERLEMLGDSFLKHAITTYLFCTYPDAHEGRLSYMRSKKVSNCNLYRLGKKKGSPSRMVVSIFDPPVNWLPPGYIVNQDKSSDKWESNETSGEGVMANGKIDEDFDDDDEEDEDLMWRNPKEETDFDDDFLEYDQEHIKFIDSMLMGSGAFVKKIPLSSFAPPDQNYEWRAPKKPLLESAQFPSEFDDFDYSSWDAMCYLDPSKAVEEDDFVVGFWNPSEENCGTDVGKQSISYDLHTEQCIADKSIADCVEALLGCYLTSCGERAAQLFLCSLGLKVLPQVRRSVTSTNSISASSSYQKTSTRDICTLNSELSSCKGVEYGYLKIPPRCMFEHPDAEKTLDHLISGFENFEKKINYPFKNKAYLLQAFTHASYHYNTITDCYQRLEFLGDAILDYLITKHLYEDPRQHSPGVLTDLRSALVNNTIFASLAVKYDYHKYFKAISPELFHVIDDFVQFQLEKNEMQGMDSELRRSEEDEEKEEDIEVPKAMGDIFESLAGAIYMDSGMSLETVWRVYYPMMHPLIEKFSANVPRSPVRELLEMEPETAKFSPAERTYDGKVRVTVEVVGKGKFKGVGRSYRIAKSAAARRALRSLKANQSQVPNS", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more RNase_III_dom, dsRBD_dom, Dicer_PBD, Helicase_ATP-bd, RNase_III_dom, PAZ_dom, DICER_DSRM, PAZ_dom, Helicase_ATP-bd, Helicase_C-like, Dicer_dimerisation_dom, RNase_III_dom, RNase_III_dom, Helicase_C-like, Dicer_dimerisation_dom, Dicer_platform, RNase_III_dom, dsRBD_dom, PAZ_dom, RNase_III_dom, RNase_III_dom, DICER_DSRM, DEAD/DEAH_box_helicase_dom, RNase_III_dom, RNase_III_dom, Helicase_C-like that are essential for its biological function; 2. The protein should be classified within P-loop_NTPase, RNase_III_sf, P-loop_NTPase, RNase_III_sf, Dicer_dimer_sf, RNase_III_sf, P-loop_NTPase, PAZ_dom_sf, RNase_III_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MAGLQLMTPASSPMGPFFGLPWQQEAIHDNIYTPRKYQVELLEAALDHNTIVCLNSGSGKTFIAVLLSKELSYQIRGDFSKNAKRTVFLVNSEKQVSQQVSAVRTHTDLKVGEYSDLQKTQCWAKEKWYQEFETRQVLVMTCHIFLNVLKSGNVSLSNINLLVFDECHLAIQDHPYREIMKICESCQPCPRILGLTASILNGKCDPRDLEEKIQKLEKILRSNAETATDLVVLDRYASQPCEIVLDCGPYVDRSGLFQRLLNELDEALNFLIDCNISTHSKERDSTIISKQILSDCRAVLLVLGPWCADKVAGMMVRELQKYIKHEQEELHRKFLLFTDTILRKIHALCEEHFSPASLDMKFVTPKVIKLLEILRKYKPYERQQFESVEWYNNRNQDNYVSWSDSEDDDDDEDEEIEEKEKTETSFPSPFTNILCGIIFVERRYTAVVLNRLIKEAGKQDPELAYISSNFITGHGIGKNQPRNKQMEVEFRKQEEVLRKFRAHETNLLIATSIVEEGVDIPKCNLVVRFDLPSEYRSYVQSKGRARAPISNYIMLADSDKIKTFEEDLKTYKAIEKILRNKCSKSIDCGNTESEPVVDDDEIFPPYVLRQDDGSPRVTINTAIGHINRYCARLPSDPFTHLAPKCKTREMSDGPYRSTLYLPINSPLRAPIVGPPMNCARLAERAVALICCKKLHEIGELDDHLMPVGKETVKYEEELDLHDEEETSVPGRPGSTKRRQCYPKAIPECLRNSYPKPGQPCYLYVIGMVLTTPLPDELNFRRRKLYPPEDTTRCFGILTAKPIPQIPHFPVYTRSGEVTISIELKKSGFTLNLEQLELITRLHQYIFSHILRLEKPALEFKPTVADCAYCVLPLNVVNDSGTLDIDFKFVEDIEKSEARTGIPNTQYSAESPFIFKLEDYQDAVIIPRYRNFDQPHRFYVADVYTDLTPLSKFPSPEYETFAEYYKTKYNLDLTNLNQPLLDVDHTSSRLNLLTPRHLNQKGKALPLSSAEKRKAKWESLQNKQILVPELCAIHPVPASLWRKAVCLPSILYRLHCLLTAEELRAQTAIDAGVGVKSLPEDFRYPNLDFGWKRSIDSKTFISSQSSSAVESEGDCRLNTTMVPDSATSSAANHVIYTQTNDQMSVNCTPLCQKSLSDLRGVCFSEDYKAINGVSCNGVTSDSEAESGVCFQKDERIACTQEIPEKSTSFHIQNLPKENQPILNECTLSKKFLDGNVSKPTSDECPSTCTSDMQYESGLSNGYSSKTLGPNPGLILQALTLSNASDGFNLERLEMLGDSFLKHAITTYLFCTYPDAHEGRLSYMRSKKVSNCNLYRLGKKKGSPSRMVVSIFDPPVNWLPPGYIVNQDKSSDKWESNETSGEGVMANGKIDEDFDDDDEEDEDLMWRNPKEETDFDDDFLEYDQEHIKFIDSMLMGSGAFVKKIPLSSFAPPDQNYEWRAPKKPLLESAQFPSEFDDFDYSSWDAMCYLDPSKAVEEDDFVVGFWNPSEENCGTDVGKQSISYDLHTEQCIADKSIADCVEALLGCYLTSCGERAAQLFLCSLGLKVLPQVRRSVTSTNSISASSSYQKTSTRDICTLNSELSSCKGVEYGYLKIPPRCMFEHPDAEKTLDHLISGFENFEKKINYPFKNKAYLLQAFTHASYHYNTITDCYQRLEFLGDAILDYLITKHLYEDPRQHSPGVLTDLRSALVNNTIFASLAVKYDYHKYFKAISPELFHVIDDFVQFQLEKNEMQGMDSELRRSEEDEEKEEDIEVPKAMGDIFESLAGAIYMDSGMSLETVWRVYYPMMHPLIEKFSANVPRSPVRELLEMEPETAKFSPAERTYDGKVRVTVEVVGKGKFKGVGRSYRIAKSAAARRALRSLKANQSQVPNS" }, { "InterPro": [ { "InterPro-ID": "IPR010636", "InterPro-Name": "Cerato-ulmin_hydrophobin", "InterPro-Type": "FAMILY", "Beg": 72, "End": 137 }, { "InterPro-ID": "IPR010636", "InterPro-Name": "Cerato-ulmin_hydrophobin", "InterPro-Type": "FAMILY", "Beg": 73, "End": 137 }, { "InterPro-ID": "IPR010636", "InterPro-Name": "Cerato-ulmin_hydrophobin", "InterPro-Type": "FAMILY", "Beg": 77, "End": 138 }, { "InterPro-ID": "IPR036686", "InterPro-Name": "Hydrophobin_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 67, "End": 141 }, { "InterPro-ID": "IPR036686", "InterPro-Name": "Hydrophobin_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 73, "End": 140 } ], "response#1": "MKFLTVAIVLAAAASAAPTKEVLPYPPVVAPPPYGGIAPDHNPPFGGGIPPINSGGLPPTNGAYPGGNNRHLCPSGLLYTNPQCCSAGVLGVADLDCKTPSSVPMNGADFERICAADGSKAQCCSVPVAGLALLCQDAIGTN", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Cerato-ulmin_hydrophobin, Cerato-ulmin_hydrophobin, Cerato-ulmin_hydrophobin that shares evolutionary origin and functional similarity; 2. The protein should be classified within Hydrophobin_sf, Hydrophobin_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MKFLTVAIVLAAAASAAPTKEVLPYPPVVAPPPYGGIAPDHNPPFGGGIPPINSGGLPPTNGAYPGGNNRHLCPSGLLYTNPQCCSAGVLGVADLDCKTPSSVPMNGADFERICAADGSKAQCCSVPVAGLALLCQDAIGTN" }, { "InterPro": [ { "InterPro-ID": "IPR010636", "InterPro-Name": "Cerato-ulmin_hydrophobin", "InterPro-Type": "FAMILY", "Beg": 30, "End": 94 }, { "InterPro-ID": "IPR036686", "InterPro-Name": "Hydrophobin_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 27, "End": 97 }, { "InterPro-ID": "IPR010636", "InterPro-Name": "Cerato-ulmin_hydrophobin", "InterPro-Type": "FAMILY", "Beg": 3, "End": 94 }, { "InterPro-ID": "IPR010636", "InterPro-Name": "Cerato-ulmin_hydrophobin", "InterPro-Type": "FAMILY", "Beg": 29, "End": 92 }, { "InterPro-ID": "IPR036686", "InterPro-Name": "Hydrophobin_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 29, "End": 96 } ], "response#1": "MKFFVVAALFAGALAAPTELEARTYPVVLCPEGLYANPVCADVDVLGILCLNAVSPSEAPRDANHFREICAKIGKQARCAVLPVLNQAVLCNKPVGITN", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Cerato-ulmin_hydrophobin, Cerato-ulmin_hydrophobin, Cerato-ulmin_hydrophobin that shares evolutionary origin and functional similarity; 2. The protein should be classified within Hydrophobin_sf, Hydrophobin_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MKFFVVAALFAGALAAPTELEARTYPVVLCPEGLYANPVCADVDVLGILCLNAVSPSEAPRDANHFREICAKIGKQARCAVLPVLNQAVLCNKPVGITN" }, { "InterPro": [ { "InterPro-ID": "IPR043472", "InterPro-Name": "Macro_dom-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 81, "End": 300 }, { "InterPro-ID": "IPR002589", "InterPro-Name": "Macro_dom", "InterPro-Type": "DOMAIN", "Beg": 111, "End": 259 }, { "InterPro-ID": "IPR002589", "InterPro-Name": "Macro_dom", "InterPro-Type": "DOMAIN", "Beg": 99, "End": 299 }, { "InterPro-ID": "IPR002589", "InterPro-Name": "Macro_dom", "InterPro-Type": "DOMAIN", "Beg": 130, "End": 259 }, { "InterPro-ID": "IPR026590", "InterPro-Name": "Ssirtuin_cat_dom", "InterPro-Type": "DOMAIN", "Beg": 307, "End": 597 }, { "InterPro-ID": "IPR029035", "InterPro-Name": "DHS-like_NAD/FAD-binding_dom", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 309, "End": 596 }, { "InterPro-ID": "IPR043472", "InterPro-Name": "Macro_dom-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 75, "End": 296 } ], "response#1": "MRTTLTGTASVLDTTLTRLIDDVIENGSSFLADDENLQHYKQHLSHLETASKIALLRECLCVRPPLPLLPEDLLQNVDSILTRVRQHKILTPIFSLSPSRLIKHGDLGATRIHLWRGDITTLTGVTAITNAANSQGLGCFQPTHRCIDNIIHAEAGPRLREECFQRMQARGKELEPGEVLVTEGHALFASSVMHTVGPQLKRGASPTETERRQLAKCYESILEALELLPSDEDGSKSIALCCISTGLFAFPADEAAEIAVSTVTSWLQKHPSTTITDVIFNTFTQSDTEFYSKLLGPSHTKSISPVENTPQGSLSLAREWLSSADAVLVTAGAGLSAAEGLDYHSRDLFKRNFPGCLKFGLTSLYSVFGFNDWPSEEHRWGYFFTHLNMVANWSNTPTYQILIPWLRNFGQDAFVRTSNADGLFLANGWPKEQLSTPQGSYGYLQCLNNCRVDAVVPSAPLVADAMPHIDKATQKLMDPSKIPLCRFCGSKMSICVRAGSWFNQAPYQEGEAQWKAWKSRVLREKKNLVILELGVGMNTPGVLRWPNEDLVMRSDGRVKLIRVGMGPEAMVPWEQEDEGLSTCVQGDIGRAIPLLLE", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Macro_dom, Macro_dom, Macro_dom, Ssirtuin_cat_dom that are essential for its biological function; 2. The protein should be classified within Macro_dom-like, DHS-like_NAD/FAD-binding_dom, Macro_dom-like sharing conserved structural features. The designed protein sequence is ", "reference": "MRTTLTGTASVLDTTLTRLIDDVIENGSSFLADDENLQHYKQHLSHLETASKIALLRECLCVRPPLPLLPEDLLQNVDSILTRVRQHKILTPIFSLSPSRLIKHGDLGATRIHLWRGDITTLTGVTAITNAANSQGLGCFQPTHRCIDNIIHAEAGPRLREECFQRMQARGKELEPGEVLVTEGHALFASSVMHTVGPQLKRGASPTETERRQLAKCYESILEALELLPSDEDGSKSIALCCISTGLFAFPADEAAEIAVSTVTSWLQKHPSTTITDVIFNTFTQSDTEFYSKLLGPSHTKSISPVENTPQGSLSLAREWLSSADAVLVTAGAGLSAAEGLDYHSRDLFKRNFPGCLKFGLTSLYSVFGFNDWPSEEHRWGYFFTHLNMVANWSNTPTYQILIPWLRNFGQDAFVRTSNADGLFLANGWPKEQLSTPQGSYGYLQCLNNCRVDAVVPSAPLVADAMPHIDKATQKLMDPSKIPLCRFCGSKMSICVRAGSWFNQAPYQEGEAQWKAWKSRVLREKKNLVILELGVGMNTPGVLRWPNEDLVMRSDGRVKLIRVGMGPEAMVPWEQEDEGLSTCVQGDIGRAIPLLLE" }, { "InterPro": [ { "InterPro-ID": "IPR001245", "InterPro-Name": "Ser-Thr/Tyr_kinase_cat_dom", "InterPro-Type": "DOMAIN", "Beg": 87, "End": 359 }, { "InterPro-ID": "IPR050823", "InterPro-Name": "Plant_Ser_Thr_Prot_Kinase", "InterPro-Type": "FAMILY", "Beg": 37, "End": 363 }, { "InterPro-ID": "IPR011009", "InterPro-Name": "Kinase-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 52, "End": 360 }, { "InterPro-ID": "IPR008271", "InterPro-Name": "Ser/Thr_kinase_AS", "InterPro-Type": "ACTIVE_SITE", "Beg": 209, "End": 221 }, { "InterPro-ID": "IPR000719", "InterPro-Name": "Prot_kinase_dom", "InterPro-Type": "DOMAIN", "Beg": 83, "End": 364 } ], "response#1": "MAVMKFTWRSIIPRCSKGIEEAEAEAEAETKKQDSKQGSFSRLAMIDFSYPSSMFTEDLSTSLAGSNLYVFTLEELKVITQCFSSANFLGEGGFGPVHKGFIDDNLRPGLEAQPVAVKLLDLEGLQGHREWLTEVVFLAQLSHPHLVKLIGYCCEDENRLLVYEYMPRGSLENQLFAKYSVPLPWSTRMKIALGAAKGLAYLHEAEKPVIYRDFKASNILLDSDYSAKLSDFGLAKDGPEGDKTHVSTRVMGTRGYAAPEYIMTGHLTAMSDVYSFGVVLLELLTGRRSLDKSRSPREQNLAEWARPMLNESRRLARIMDPKLEGQYSETGARKAAALAYQCLSHRAKQRPKMSDVVNILEPLLDYGETSVASFVYTVPTHQKGGSPPKDDTDTKECEAKTELKKENGHHRNRHHHRRSHKSRDGHRHQNKSSSQSSVHSENDTSKQNLENGSNEECNID", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Ser-Thr/Tyr_kinase_cat_dom, Prot_kinase_dom that are essential for its biological function; 2. The protein should belong to Plant_Ser_Thr_Prot_Kinase that shares evolutionary origin and functional similarity; 3. The protein should be classified within Kinase-like_dom_sf sharing conserved structural features; 4. The protein must have Ser/Thr_kinase_AS that is conserved among related catalytic enzymes. The designed protein sequence is ", "reference": "MAVMKFTWRSIIPRCSKGIEEAEAEAEAETKKQDSKQGSFSRLAMIDFSYPSSMFTEDLSTSLAGSNLYVFTLEELKVITQCFSSANFLGEGGFGPVHKGFIDDNLRPGLEAQPVAVKLLDLEGLQGHREWLTEVVFLAQLSHPHLVKLIGYCCEDENRLLVYEYMPRGSLENQLFAKYSVPLPWSTRMKIALGAAKGLAYLHEAEKPVIYRDFKASNILLDSDYSAKLSDFGLAKDGPEGDKTHVSTRVMGTRGYAAPEYIMTGHLTAMSDVYSFGVVLLELLTGRRSLDKSRSPREQNLAEWARPMLNESRRLARIMDPKLEGQYSETGARKAAALAYQCLSHRAKQRPKMSDVVNILEPLLDYGETSVASFVYTVPTHQKGGSPPKDDTDTKECEAKTELKKENGHHRNRHHHRRSHKSRDGHRHQNKSSSQSSVHSENDTSKQNLENGSNEECNID" }, { "InterPro": [ { "InterPro-ID": "IPR002048", "InterPro-Name": "EF_hand_dom", "InterPro-Type": "DOMAIN", "Beg": 78, "End": 109 }, { "InterPro-ID": "IPR008080", "InterPro-Name": "Parvalbumin", "InterPro-Type": "FAMILY", "Beg": 1, "End": 108 }, { "InterPro-ID": "IPR002048", "InterPro-Name": "EF_hand_dom", "InterPro-Type": "DOMAIN", "Beg": 39, "End": 74 }, { "InterPro-ID": "IPR011992", "InterPro-Name": "EF-hand-dom_pair", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 3, "End": 107 }, { "InterPro-ID": "IPR018247", "InterPro-Name": "EF_Hand_1_Ca_BS", "InterPro-Type": "BINDING_SITE", "Beg": 91, "End": 103 }, { "InterPro-ID": "IPR018247", "InterPro-Name": "EF_Hand_1_Ca_BS", "InterPro-Type": "BINDING_SITE", "Beg": 52, "End": 64 }, { "InterPro-ID": "IPR002048", "InterPro-Name": "EF_hand_dom", "InterPro-Type": "DOMAIN", "Beg": 43, "End": 71 }, { "InterPro-ID": "IPR002048", "InterPro-Name": "EF_hand_dom", "InterPro-Type": "DOMAIN", "Beg": 82, "End": 109 }, { "InterPro-ID": "IPR002048", "InterPro-Name": "EF_hand_dom", "InterPro-Type": "DOMAIN", "Beg": 43, "End": 107 } ], "response#1": "MAITDILSAKDIEAALSSCQAAESFNYKSFFSTVGLKGKSADQVKKVFGILDQDKSGFIEEDELQLFLKNFSSSARALTDAETKAFLAAGDTDGDGKIGVDEFQALVKA", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more EF_hand_dom, EF_hand_dom, EF_hand_dom, EF_hand_dom, EF_hand_dom that are essential for its biological function; 2. The protein should belong to Parvalbumin that shares evolutionary origin and functional similarity; 3. The protein should be classified within EF-hand-dom_pair sharing conserved structural features; 4. The protein should include a EF_Hand_1_Ca_BS, EF_Hand_1_Ca_BS that enables ligand binding under diverse conditions. The designed protein sequence is ", "reference": "MAITDILSAKDIEAALSSCQAAESFNYKSFFSTVGLKGKSADQVKKVFGILDQDKSGFIEEDELQLFLKNFSSSARALTDAETKAFLAAGDTDGDGKIGVDEFQALVKA" }, { "InterPro": [ { "InterPro-ID": "IPR049521", "InterPro-Name": "DUF4556", "InterPro-Type": "DOMAIN", "Beg": 254, "End": 361 }, { "InterPro-ID": "IPR027956", "InterPro-Name": "C1orf127-like", "InterPro-Type": "FAMILY", "Beg": 20, "End": 448 }, { "InterPro-ID": "IPR054554", "InterPro-Name": "ZP1/4_Ig-like", "InterPro-Type": "DOMAIN", "Beg": 86, "End": 146 } ], "response#1": "MKNQHNTFWVLCLLFVMFDETFSAFPFGNGRIQFDPIRENSSDNIECFLDYMELWVPRKQINGLVLWLSQIMRFPVSLSSLDRSNQQLSRCKYFLDADADGNFLFRVHYTGCYVQTQEGFYKLEIHMVKKTSSGRGQSNRYLMRCPAMTAQLGREKLRCDPNYVQVSRPIPLGNSNDQADWFFSLRGELVVSIEDASLIGVEVDVSNSSVTVSGLRGQLLDGIKILDRQIDNLHLWLAHGFYAYSLEASCPSVSQHPGEEVILHIPKQRVGLVKRGSYSADILTLKNLIVGQSANVTVTVTENKQFVVINIPSHEVLQRQDCYTTIGNNPGVQFFYCIDLVLEFTEMAYPINWTLENYYECSVRVPQMIQPKPTTAETFHKIKLELHTTPRSETRTALVITPTQDNTLASTSVTLAAKLRESVHSAIVQESSKTEMSASGYDAELDHVASGEYFNRIEGSGYYAETNISAALRLRKCHHL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more DUF4556, ZP1/4_Ig-like that are essential for its biological function; 2. The protein should belong to C1orf127-like that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MKNQHNTFWVLCLLFVMFDETFSAFPFGNGRIQFDPIRENSSDNIECFLDYMELWVPRKQINGLVLWLSQIMRFPVSLSSLDRSNQQLSRCKYFLDADADGNFLFRVHYTGCYVQTQEGFYKLEIHMVKKTSSGRGQSNRYLMRCPAMTAQLGREKLRCDPNYVQVSRPIPLGNSNDQADWFFSLRGELVVSIEDASLIGVEVDVSNSSVTVSGLRGQLLDGIKILDRQIDNLHLWLAHGFYAYSLEASCPSVSQHPGEEVILHIPKQRVGLVKRGSYSADILTLKNLIVGQSANVTVTVTENKQFVVINIPSHEVLQRQDCYTTIGNNPGVQFFYCIDLVLEFTEMAYPINWTLENYYECSVRVPQMIQPKPTTAETFHKIKLELHTTPRSETRTALVITPTQDNTLASTSVTLAAKLRESVHSAIVQESSKTEMSASGYDAELDHVASGEYFNRIEGSGYYAETNISAALRLRKCHHL" }, { "InterPro": [ { "InterPro-ID": "IPR036686", "InterPro-Name": "Hydrophobin_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 490, "End": 564 }, { "InterPro-ID": "IPR036686", "InterPro-Name": "Hydrophobin_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 496, "End": 564 }, { "InterPro-ID": "IPR010636", "InterPro-Name": "Cerato-ulmin_hydrophobin", "InterPro-Type": "FAMILY", "Beg": 496, "End": 558 }, { "InterPro-ID": "IPR010636", "InterPro-Name": "Cerato-ulmin_hydrophobin", "InterPro-Type": "FAMILY", "Beg": 499, "End": 561 }, { "InterPro-ID": "IPR010636", "InterPro-Name": "Cerato-ulmin_hydrophobin", "InterPro-Type": "FAMILY", "Beg": 497, "End": 561 } ], "response#1": "MKSKSIMAASTVMELALAQASADPLCSTIINLQPIEYQFQQPVLIDSYFPANTDIVLDDGHVVHVTNAPTSLSTVLTDVSTSSTTLTSSASNGNGNPPDGGYLTFTVPANPDDIGNHPVTKTYPPTEPGQPGIVVIQVPTSPPGADGIPTSSVPYVTVTTTGDFPSLTGPVTTTVTPGEPGATGSVIIEVPNTKITSPSASYVTVTTPGSVAPTDAPRTSTIPPSNPTDPGTVIVVVPSSQASSVSSIPFVTVTTTGSTLNPTDDPITSTISPSGSTGSGTVIVEVPPSSSPSGSGASSSPVSVVTRTVTGDDGNGEPSTTTITPTASSGPGTVIVEVPPPTNSPSATSPGSSRPGGPGSSGTGSSASQGPSDSAALSSSTGDAGPSSSVPETSSPSRATTDDAASSTSASAPASSSAASSITQSETPSSAGAETSTPATSPASSSAPSTSDADTSSPVNPTTSSPASSAATSAPGSSTESAPSSSTSSAAANFDPCPDSLYGNPQCCSVDVLGVADVECDSPTESPTDADNFQAICAASGQRARCCVLPVLGQALVCLTPVGVSN", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Cerato-ulmin_hydrophobin, Cerato-ulmin_hydrophobin, Cerato-ulmin_hydrophobin that shares evolutionary origin and functional similarity; 2. The protein should be classified within Hydrophobin_sf, Hydrophobin_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MKSKSIMAASTVMELALAQASADPLCSTIINLQPIEYQFQQPVLIDSYFPANTDIVLDDGHVVHVTNAPTSLSTVLTDVSTSSTTLTSSASNGNGNPPDGGYLTFTVPANPDDIGNHPVTKTYPPTEPGQPGIVVIQVPTSPPGADGIPTSSVPYVTVTTTGDFPSLTGPVTTTVTPGEPGATGSVIIEVPNTKITSPSASYVTVTTPGSVAPTDAPRTSTIPPSNPTDPGTVIVVVPSSQASSVSSIPFVTVTTTGSTLNPTDDPITSTISPSGSTGSGTVIVEVPPSSSPSGSGASSSPVSVVTRTVTGDDGNGEPSTTTITPTASSGPGTVIVEVPPPTNSPSATSPGSSRPGGPGSSGTGSSASQGPSDSAALSSSTGDAGPSSSVPETSSPSRATTDDAASSTSASAPASSSAASSITQSETPSSAGAETSTPATSPASSSAPSTSDADTSSPVNPTTSSPASSAATSAPGSSTESAPSSSTSSAAANFDPCPDSLYGNPQCCSVDVLGVADVECDSPTESPTDADNFQAICAASGQRARCCVLPVLGQALVCLTPVGVSN" }, { "InterPro": [ { "InterPro-ID": "IPR010636", "InterPro-Name": "Cerato-ulmin_hydrophobin", "InterPro-Type": "FAMILY", "Beg": 1, "End": 95 }, { "InterPro-ID": "IPR036686", "InterPro-Name": "Hydrophobin_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 29, "End": 98 }, { "InterPro-ID": "IPR010636", "InterPro-Name": "Cerato-ulmin_hydrophobin", "InterPro-Type": "FAMILY", "Beg": 28, "End": 93 }, { "InterPro-ID": "IPR010636", "InterPro-Name": "Cerato-ulmin_hydrophobin", "InterPro-Type": "FAMILY", "Beg": 29, "End": 95 }, { "InterPro-ID": "IPR036686", "InterPro-Name": "Hydrophobin_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 19, "End": 98 } ], "response#1": "MQFYTIVSLFLAGTAYALPATSANGYEACPSGGLFGNPQCCSLNLVGVLSGDCRAPTKTPNSAKEFQAICAESGQKARCCGLSEILELGAFCQKPVGVSA", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Cerato-ulmin_hydrophobin, Cerato-ulmin_hydrophobin, Cerato-ulmin_hydrophobin that shares evolutionary origin and functional similarity; 2. The protein should be classified within Hydrophobin_sf, Hydrophobin_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MQFYTIVSLFLAGTAYALPATSANGYEACPSGGLFGNPQCCSLNLVGVLSGDCRAPTKTPNSAKEFQAICAESGQKARCCGLSEILELGAFCQKPVGVSA" }, { "InterPro": [ { "InterPro-ID": "IPR036389", "InterPro-Name": "RNase_III_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1270, "End": 1568 }, { "InterPro-ID": "IPR005034", "InterPro-Name": "Dicer_dimerisation_dom", "InterPro-Type": "DOMAIN", "Beg": 622, "End": 714 }, { "InterPro-ID": "IPR001650", "InterPro-Name": "Helicase_C-like", "InterPro-Type": "DOMAIN", "Beg": 491, "End": 545 }, { "InterPro-ID": "IPR000999", "InterPro-Name": "RNase_III_dom", "InterPro-Type": "DOMAIN", "Beg": 1290, "End": 1363 }, { "InterPro-ID": "IPR000999", "InterPro-Name": "RNase_III_dom", "InterPro-Type": "DOMAIN", "Beg": 1661, "End": 1783 }, { "InterPro-ID": "IPR036085", "InterPro-Name": "PAZ_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 922, "End": 980 }, { "InterPro-ID": "IPR000999", "InterPro-Name": "RNase_III_dom", "InterPro-Type": "DOMAIN", "Beg": 1640, "End": 1806 }, { "InterPro-ID": "IPR000999", "InterPro-Name": "RNase_III_dom", "InterPro-Type": "DOMAIN", "Beg": 1272, "End": 1570 }, { "InterPro-ID": "IPR000999", "InterPro-Name": "RNase_III_dom", "InterPro-Type": "DOMAIN", "Beg": 1641, "End": 1805 }, { "InterPro-ID": "IPR001650", "InterPro-Name": "Helicase_C-like", "InterPro-Type": "DOMAIN", "Beg": 425, "End": 594 }, { "InterPro-ID": "IPR044441", "InterPro-Name": "DICER_DSRM", "InterPro-Type": "DOMAIN", "Beg": 1789, "End": 1877 }, { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 83, "End": 557 }, { "InterPro-ID": "IPR003100", "InterPro-Name": "PAZ_dom", "InterPro-Type": "DOMAIN", "Beg": 887, "End": 1034 }, { "InterPro-ID": "IPR036389", "InterPro-Name": "RNase_III_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1267, "End": 1560 }, { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 29, "End": 254 }, { "InterPro-ID": "IPR005034", "InterPro-Name": "Dicer_dimerisation_dom", "InterPro-Type": "DOMAIN", "Beg": 622, "End": 710 }, { "InterPro-ID": "IPR000999", "InterPro-Name": "RNase_III_dom", "InterPro-Type": "DOMAIN", "Beg": 1273, "End": 1353 }, { "InterPro-ID": "IPR011545", "InterPro-Name": "DEAD/DEAH_box_helicase_dom", "InterPro-Type": "DOMAIN", "Beg": 36, "End": 199 }, { "InterPro-ID": "IPR003100", "InterPro-Name": "PAZ_dom", "InterPro-Type": "DOMAIN", "Beg": 883, "End": 1058 }, { "InterPro-ID": "IPR036389", "InterPro-Name": "RNase_III_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1611, "End": 1808 }, { "InterPro-ID": "IPR048512", "InterPro-Name": "Dicer_platform", "InterPro-Type": "DOMAIN", "Beg": 753, "End": 878 }, { "InterPro-ID": "IPR000999", "InterPro-Name": "RNase_III_dom", "InterPro-Type": "DOMAIN", "Beg": 1661, "End": 1669 }, { "InterPro-ID": "IPR014001", "InterPro-Name": "Helicase_ATP-bd", "InterPro-Type": "DOMAIN", "Beg": 41, "End": 217 }, { "InterPro-ID": "IPR001650", "InterPro-Name": "Helicase_C-like", "InterPro-Type": "DOMAIN", "Beg": 451, "End": 548 }, { "InterPro-ID": "IPR048513", "InterPro-Name": "Dicer_PBD", "InterPro-Type": "DOMAIN", "Beg": 258, "End": 356 }, { "InterPro-ID": "IPR038248", "InterPro-Name": "Dicer_dimer_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 617, "End": 717 }, { "InterPro-ID": "IPR036389", "InterPro-Name": "RNase_III_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1625, "End": 1806 }, { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 403, "End": 580 }, { "InterPro-ID": "IPR003100", "InterPro-Name": "PAZ_dom", "InterPro-Type": "DOMAIN", "Beg": 917, "End": 1054 }, { "InterPro-ID": "IPR014720", "InterPro-Name": "dsRBD_dom", "InterPro-Type": "DOMAIN", "Beg": 1809, "End": 1872 }, { "InterPro-ID": "IPR014001", "InterPro-Name": "Helicase_ATP-bd", "InterPro-Type": "DOMAIN", "Beg": 30, "End": 233 }, { "InterPro-ID": "IPR000999", "InterPro-Name": "RNase_III_dom", "InterPro-Type": "DOMAIN", "Beg": 1625, "End": 1783 }, { "InterPro-ID": "IPR014720", "InterPro-Name": "dsRBD_dom", "InterPro-Type": "DOMAIN", "Beg": 1811, "End": 1873 }, { "InterPro-ID": "IPR044441", "InterPro-Name": "DICER_DSRM", "InterPro-Type": "DOMAIN", "Beg": 1810, "End": 1872 }, { "InterPro-ID": "IPR000999", "InterPro-Name": "RNase_III_dom", "InterPro-Type": "DOMAIN", "Beg": 1261, "End": 1339 } ], "response#1": "MAGLQLMTPASSPMGPFFGLPWQQEAIHDNIYTPRKYQVELLEAALDHNIIVCLNSGSGKTFIAVLLSKELSYQIRGDFSKNAKRTVFLVNSEKQVSQQVSAVRTHTDLKVGEYSDLQKTQCWAKEKWYQEFQTHQVLVMTCHIFLNVLKTGNVSLSNINLLVFDECHLAIQDHPYRDIMKICESCQTCPRILGLTASILNGKCDPHDLEEKIQNLEEILRSNAETATDLVVLDRYASQPCEIVLDCGPYVDRSGLYQRLLNELDEALNFLTDCNISTHSKERDSTIISKQILSDCWAVLLVLGPWCADKVAGMMVRELQKYIKHEQEELHRKFLLFTDTILRKIHALCEEHFSPASLDMKFVTPKVIKLLEILRKYKPYERQQFESVEWYNNRNQDNYVSWSDSEDDDDDEDEEIEEKEKTETSFPSPFTNILCGIIFVERRYTAVVLNRLIKEAGKQDPELAYISSNFITGHGIGKNQPRNKQMEVEFRKQEEVLRKFRAHETNLLIATSIVEEGVDIPKCNLVVRFDLPSEYRSYVQSKGRARAPISNYIMLADSDKIKAFEEDLKTYKAIEKILRNKCSKSMDCGNTESEPIVDDDEIFPPYVLRQDDGSPRVTINTAIGHINRYCARLPSDPFTHLAPKCRTRELPDGPYRSTLYLPINSPLRAPIVGPPMNCARLAERAVALICCKKLHEIGELDDHLMPVGKETVKYEEELDLHDEEETSVPGRPGSTKRRQCYPKAIPECLRNSYPKPGQPCYLYVIGMVLTTPLPDELNFRRRKLYPPEDTTRCFGILTAKPIPQIPHFPVYTRSGEVTISIELKKSGFSLNLEQLELITRLHRYIFSHILRLEKPALEFKPTVADCAYCVLPLNVVNDSGTLDIDFKFVEDIEKSEARTGIPNTQYSAEGPFIFKLEDYQDAVIIPRYRNFDQPHRFYVADVYTDLTPLSKFPSPEYETFAEYYKTKYNLDLTNLNQPLLDVDHTSSRLNLLTPRHLNQKGKALPLSSAEKRKAKWESLQNKQILVPELCAIHPVPASLWRKAVCLPSILYRLHCLLTAEELRAQTAIDAGVGVKSLPEDFRYPNLDFGWKRSIDGKTFISNQSFSAMERESDCRLDITTVPDSATSSAAHHVMYTQMNDQMSVNCTPPCPKSLSDLQGVCFSDDCKAINGITCNGLTNGNWEAESGVCFQKDELIACKQEIPEKSTSFHVQNLPNDNQPILNECTLSKKFLDGNVGKPISDECPSTCTSDINYESGLSSGYSSKTLGPNPGLILQALTLSNASDGFNLERLEMLGDSFLKHAITTYLFCTYPDSHEGRLSYMRSKKVSNCNLYRLGKKKGSPSRMVVSIFDPPVNWLPPGYIVNQDKNCDKWESNETSGESVMANGKIDEDFEDEEDEDLMWRNPKEETDFDDDFLEYDQEHIKFIDNMLMGSGAFVKKIQLSAFAPPDQNYEWRPPKKPPLESAPFRSEFDDFDYSSWDAMCYLDPSKAVEEDDFVVGFWNPSEENGGADAGKQSISYDLHTEQCIADKSIADCVEALLGCYLTSCGERAAQLFLCSLGLKVLPEVRKPVTNTSTRGNYSLDGRTNSELSCKGIEYGYLKIPPRCMFEHPEAEKTLDHLISGFENFEKKINYQFKNKAYLLQAFTHASYHYNTITDCYQRLEFLGDAILDYLITKHLYEDPRQHSPGVLTDLRSALVNNTIFASLAVKYDYHKYFKAISPELFHVIDDFVQFQLEKNEMQGMDSELRRSEEDEEKEEDIEVPKAMGDIFESLAGAIYMDSGMSLETVWRVYYPMMQPLIEKFSANVPRSPVRELLEMEPETAKFSPAERTYDGKVRVMVEVVGKGKFKGVGRSYRIAKSAAARRALRSLKANQSQVPNS", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Dicer_dimerisation_dom, Helicase_C-like, RNase_III_dom, RNase_III_dom, RNase_III_dom, RNase_III_dom, RNase_III_dom, Helicase_C-like, DICER_DSRM, PAZ_dom, Dicer_dimerisation_dom, RNase_III_dom, DEAD/DEAH_box_helicase_dom, PAZ_dom, Dicer_platform, RNase_III_dom, Helicase_ATP-bd, Helicase_C-like, Dicer_PBD, PAZ_dom, dsRBD_dom, Helicase_ATP-bd, RNase_III_dom, dsRBD_dom, DICER_DSRM, RNase_III_dom that are essential for its biological function; 2. The protein should be classified within RNase_III_sf, PAZ_dom_sf, P-loop_NTPase, RNase_III_sf, P-loop_NTPase, RNase_III_sf, Dicer_dimer_sf, RNase_III_sf, P-loop_NTPase sharing conserved structural features. The designed protein sequence is ", "reference": "MAGLQLMTPASSPMGPFFGLPWQQEAIHDNIYTPRKYQVELLEAALDHNIIVCLNSGSGKTFIAVLLSKELSYQIRGDFSKNAKRTVFLVNSEKQVSQQVSAVRTHTDLKVGEYSDLQKTQCWAKEKWYQEFQTHQVLVMTCHIFLNVLKTGNVSLSNINLLVFDECHLAIQDHPYRDIMKICESCQTCPRILGLTASILNGKCDPHDLEEKIQNLEEILRSNAETATDLVVLDRYASQPCEIVLDCGPYVDRSGLYQRLLNELDEALNFLTDCNISTHSKERDSTIISKQILSDCWAVLLVLGPWCADKVAGMMVRELQKYIKHEQEELHRKFLLFTDTILRKIHALCEEHFSPASLDMKFVTPKVIKLLEILRKYKPYERQQFESVEWYNNRNQDNYVSWSDSEDDDDDEDEEIEEKEKTETSFPSPFTNILCGIIFVERRYTAVVLNRLIKEAGKQDPELAYISSNFITGHGIGKNQPRNKQMEVEFRKQEEVLRKFRAHETNLLIATSIVEEGVDIPKCNLVVRFDLPSEYRSYVQSKGRARAPISNYIMLADSDKIKAFEEDLKTYKAIEKILRNKCSKSMDCGNTESEPIVDDDEIFPPYVLRQDDGSPRVTINTAIGHINRYCARLPSDPFTHLAPKCRTRELPDGPYRSTLYLPINSPLRAPIVGPPMNCARLAERAVALICCKKLHEIGELDDHLMPVGKETVKYEEELDLHDEEETSVPGRPGSTKRRQCYPKAIPECLRNSYPKPGQPCYLYVIGMVLTTPLPDELNFRRRKLYPPEDTTRCFGILTAKPIPQIPHFPVYTRSGEVTISIELKKSGFSLNLEQLELITRLHRYIFSHILRLEKPALEFKPTVADCAYCVLPLNVVNDSGTLDIDFKFVEDIEKSEARTGIPNTQYSAEGPFIFKLEDYQDAVIIPRYRNFDQPHRFYVADVYTDLTPLSKFPSPEYETFAEYYKTKYNLDLTNLNQPLLDVDHTSSRLNLLTPRHLNQKGKALPLSSAEKRKAKWESLQNKQILVPELCAIHPVPASLWRKAVCLPSILYRLHCLLTAEELRAQTAIDAGVGVKSLPEDFRYPNLDFGWKRSIDGKTFISNQSFSAMERESDCRLDITTVPDSATSSAAHHVMYTQMNDQMSVNCTPPCPKSLSDLQGVCFSDDCKAINGITCNGLTNGNWEAESGVCFQKDELIACKQEIPEKSTSFHVQNLPNDNQPILNECTLSKKFLDGNVGKPISDECPSTCTSDINYESGLSSGYSSKTLGPNPGLILQALTLSNASDGFNLERLEMLGDSFLKHAITTYLFCTYPDSHEGRLSYMRSKKVSNCNLYRLGKKKGSPSRMVVSIFDPPVNWLPPGYIVNQDKNCDKWESNETSGESVMANGKIDEDFEDEEDEDLMWRNPKEETDFDDDFLEYDQEHIKFIDNMLMGSGAFVKKIQLSAFAPPDQNYEWRPPKKPPLESAPFRSEFDDFDYSSWDAMCYLDPSKAVEEDDFVVGFWNPSEENGGADAGKQSISYDLHTEQCIADKSIADCVEALLGCYLTSCGERAAQLFLCSLGLKVLPEVRKPVTNTSTRGNYSLDGRTNSELSCKGIEYGYLKIPPRCMFEHPEAEKTLDHLISGFENFEKKINYQFKNKAYLLQAFTHASYHYNTITDCYQRLEFLGDAILDYLITKHLYEDPRQHSPGVLTDLRSALVNNTIFASLAVKYDYHKYFKAISPELFHVIDDFVQFQLEKNEMQGMDSELRRSEEDEEKEEDIEVPKAMGDIFESLAGAIYMDSGMSLETVWRVYYPMMQPLIEKFSANVPRSPVRELLEMEPETAKFSPAERTYDGKVRVMVEVVGKGKFKGVGRSYRIAKSAAARRALRSLKANQSQVPNS" }, { "InterPro": [ { "InterPro-ID": "IPR017853", "InterPro-Name": "Glycoside_hydrolase_SF", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 17, "End": 511 }, { "InterPro-ID": "IPR001360", "InterPro-Name": "Glyco_hydro_1", "InterPro-Type": "FAMILY", "Beg": 22, "End": 515 }, { "InterPro-ID": "IPR001360", "InterPro-Name": "Glyco_hydro_1", "InterPro-Type": "FAMILY", "Beg": 232, "End": 514 }, { "InterPro-ID": "IPR001360", "InterPro-Name": "Glyco_hydro_1", "InterPro-Type": "FAMILY", "Beg": 20, "End": 195 }, { "InterPro-ID": "IPR001360", "InterPro-Name": "Glyco_hydro_1", "InterPro-Type": "FAMILY", "Beg": 462, "End": 479 }, { "InterPro-ID": "IPR001360", "InterPro-Name": "Glyco_hydro_1", "InterPro-Type": "FAMILY", "Beg": 341, "End": 355 }, { "InterPro-ID": "IPR001360", "InterPro-Name": "Glyco_hydro_1", "InterPro-Type": "FAMILY", "Beg": 486, "End": 498 }, { "InterPro-ID": "IPR001360", "InterPro-Name": "Glyco_hydro_1", "InterPro-Type": "FAMILY", "Beg": 418, "End": 426 }, { "InterPro-ID": "IPR001360", "InterPro-Name": "Glyco_hydro_1", "InterPro-Type": "FAMILY", "Beg": 441, "End": 452 }, { "InterPro-ID": "IPR033132", "InterPro-Name": "Glyco_hydro_1_N_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 26, "End": 40 } ], "response#1": "MSSVLPTPVLPTPGRNINRGHFPDDFIFGAGTSSYQIEGAAREGGRGPSIWDTFTHTHPELIQDGSNGDTAINSYNLYKEDIKIVKLMGLDAYRFSISWPRILPGGSINAGINQEGIKYYNNLIDELLANDIVPYVTLFHWDVPQALQDQYDGFLSDKIVDDFRDFAELCFWEFGDRVKNWITINEPQSYSDFFGVAYDTPPKAHALKASRLLVPTTVARPSKPVRVFASTADPGTTTADQVYKVGHNLLLAHAAAIQVYRDKFQNTQEGTFGMALVTQWMKPLNENNPADVEAASRAFDFKFGWFMQPLITGEYPKSMRQLLGPRLREFTPDQKKLLIGSYDYVGVNYYTATYVSSAQPPHDKKKAVFHTDGNFYTTDSKDGVLIGPLAGPAWLNIVPEGIYHVLHDIKENYEDPVIYITENGVYEVNDTAKTLSEARVDTTRLHYLQDHLSKVLEARHQGVRVQGYLVWSLMDNWELRAGYTSRFGLIHVDYYNNFARYPKDSAIWFRNAFHKRLRIHVNKARPQEDDGAFDTPRKRLRKY", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Glyco_hydro_1, Glyco_hydro_1, Glyco_hydro_1, Glyco_hydro_1, Glyco_hydro_1, Glyco_hydro_1, Glyco_hydro_1, Glyco_hydro_1 that shares evolutionary origin and functional similarity; 2. The protein should be classified within Glycoside_hydrolase_SF sharing conserved structural features; 3. The protein should contain Glyco_hydro_1_N_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MSSVLPTPVLPTPGRNINRGHFPDDFIFGAGTSSYQIEGAAREGGRGPSIWDTFTHTHPELIQDGSNGDTAINSYNLYKEDIKIVKLMGLDAYRFSISWPRILPGGSINAGINQEGIKYYNNLIDELLANDIVPYVTLFHWDVPQALQDQYDGFLSDKIVDDFRDFAELCFWEFGDRVKNWITINEPQSYSDFFGVAYDTPPKAHALKASRLLVPTTVARPSKPVRVFASTADPGTTTADQVYKVGHNLLLAHAAAIQVYRDKFQNTQEGTFGMALVTQWMKPLNENNPADVEAASRAFDFKFGWFMQPLITGEYPKSMRQLLGPRLREFTPDQKKLLIGSYDYVGVNYYTATYVSSAQPPHDKKKAVFHTDGNFYTTDSKDGVLIGPLAGPAWLNIVPEGIYHVLHDIKENYEDPVIYITENGVYEVNDTAKTLSEARVDTTRLHYLQDHLSKVLEARHQGVRVQGYLVWSLMDNWELRAGYTSRFGLIHVDYYNNFARYPKDSAIWFRNAFHKRLRIHVNKARPQEDDGAFDTPRKRLRKY" }, { "InterPro": [ { "InterPro-ID": "IPR002213", "InterPro-Name": "UDP_glucos_trans", "InterPro-Type": "FAMILY", "Beg": 275, "End": 426 }, { "InterPro-ID": "IPR002213", "InterPro-Name": "UDP_glucos_trans", "InterPro-Type": "FAMILY", "Beg": 11, "End": 464 }, { "InterPro-ID": "IPR035595", "InterPro-Name": "UDP_glycos_trans_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 344, "End": 387 } ], "response#1": "MSDQNDKKVEIIVFPYHGQGHMNTMLQFAKRIAWKNAKVTIATTLSTTNKMKSKVENAWGTSITLDSIYDDSDESQIKFMDRMARFEAAAASSLSKLLVQKKEEADNKVLLVYDGNLPWALDIAHEHGVRGAAFFPQSCATVATYYSLYQETQGKELETELPAVFPPLELIQRNVPNVFGLKFPEAVVAKNGKEYSPFVLFVLRQCINLEKADLLLFNQFDKLVEPGEVLQWMSKIFNVKTIGPTLPSSYIDKRIKDDVDYGFHAFNLDNNSCINWLNSKPARSVIYIAFGSSVHYSVEQMTEIAEALKSQPNNFLWAVRETEQKKLPEDFVQQTSEKGLMLSWCPQLDVLVHESISCFVTHCGWNSITEALSFGVPMLSVPQFLDQPVDAHFVEQVWGAGITVKRSEDGLVTRDEIVRCLEVLNNGEKAEEIKANVARWKVLAKEALDEGGSSDKHIDEIIEWVSSF", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to UDP_glucos_trans, UDP_glucos_trans that shares evolutionary origin and functional similarity; 2. The protein should contain UDP_glycos_trans_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MSDQNDKKVEIIVFPYHGQGHMNTMLQFAKRIAWKNAKVTIATTLSTTNKMKSKVENAWGTSITLDSIYDDSDESQIKFMDRMARFEAAAASSLSKLLVQKKEEADNKVLLVYDGNLPWALDIAHEHGVRGAAFFPQSCATVATYYSLYQETQGKELETELPAVFPPLELIQRNVPNVFGLKFPEAVVAKNGKEYSPFVLFVLRQCINLEKADLLLFNQFDKLVEPGEVLQWMSKIFNVKTIGPTLPSSYIDKRIKDDVDYGFHAFNLDNNSCINWLNSKPARSVIYIAFGSSVHYSVEQMTEIAEALKSQPNNFLWAVRETEQKKLPEDFVQQTSEKGLMLSWCPQLDVLVHESISCFVTHCGWNSITEALSFGVPMLSVPQFLDQPVDAHFVEQVWGAGITVKRSEDGLVTRDEIVRCLEVLNNGEKAEEIKANVARWKVLAKEALDEGGSSDKHIDEIIEWVSSF" }, { "InterPro": [ { "InterPro-ID": "IPR050525", "InterPro-Name": "ECM_Assembly_Org", "InterPro-Type": "FAMILY", "Beg": 36, "End": 266 }, { "InterPro-ID": "IPR002035", "InterPro-Name": "VWF_A", "InterPro-Type": "DOMAIN", "Beg": 276, "End": 448 }, { "InterPro-ID": "IPR036465", "InterPro-Name": "vWFA_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 25, "End": 222 }, { "InterPro-ID": "IPR000742", "InterPro-Name": "EGF-like_dom", "InterPro-Type": "DOMAIN", "Beg": 248, "End": 263 }, { "InterPro-ID": "IPR036337", "InterPro-Name": "Matrilin_cc_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 454, "End": 481 }, { "InterPro-ID": "IPR019466", "InterPro-Name": "Matrilin_coiled-coil_trimer", "InterPro-Type": "DOMAIN", "Beg": 452, "End": 482 }, { "InterPro-ID": "IPR000742", "InterPro-Name": "EGF-like_dom", "InterPro-Type": "DOMAIN", "Beg": 227, "End": 264 }, { "InterPro-ID": "IPR001881", "InterPro-Name": "EGF-like_Ca-bd_dom", "InterPro-Type": "DOMAIN", "Beg": 232, "End": 264 }, { "InterPro-ID": "IPR036465", "InterPro-Name": "vWFA_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 228, "End": 453 }, { "InterPro-ID": "IPR036465", "InterPro-Name": "vWFA_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 273, "End": 465 }, { "InterPro-ID": "IPR036465", "InterPro-Name": "vWFA_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 40, "End": 231 }, { "InterPro-ID": "IPR002035", "InterPro-Name": "VWF_A", "InterPro-Type": "DOMAIN", "Beg": 42, "End": 217 }, { "InterPro-ID": "IPR019466", "InterPro-Name": "Matrilin_coiled-coil_trimer", "InterPro-Type": "DOMAIN", "Beg": 451, "End": 496 }, { "InterPro-ID": "IPR002035", "InterPro-Name": "VWF_A", "InterPro-Type": "DOMAIN", "Beg": 276, "End": 444 }, { "InterPro-ID": "IPR002035", "InterPro-Name": "VWF_A", "InterPro-Type": "DOMAIN", "Beg": 42, "End": 215 }, { "InterPro-ID": "IPR002035", "InterPro-Name": "VWF_A", "InterPro-Type": "DOMAIN", "Beg": 274, "End": 453 }, { "InterPro-ID": "IPR002035", "InterPro-Name": "VWF_A", "InterPro-Type": "DOMAIN", "Beg": 40, "End": 219 } ], "response#1": "MRALSGPRLMLCGLLLLLFQAPCALGLAPLSRGHLCRTRPTDLVFVVDSSRSVRPVEFEKVKVFLSQVIESLDVGPNATRVGLVNYASSVKQEFPLRAHSSKAELLQAVRRIQPLSTGTMTGLAIQFAITKALSDAEGGRPRSPDISKVVIVVTDGRPQDSVRDVSARARAGGIELFAIGVGRVDKATLQQIASEPQDEHVDYVESYSVIEKLSKKFQEAFCLVSDLCATGDHDCEQVCVSSPGSYTCACREGFTLNSDGKTCNVCNGGGGSSATDLVFLIDGSKSVRPENFELVKKFINQIVDTLDVSDKLAQVGLVQYSSSVRQEFPLGRFHTKKDIKAAVRNMSYMEKGTMTGAALKYLIDNSFTVSSGARPGAQKVGIVFTDGRSQDYINDAAKKAKDLGFKMFAVGVGNAVEDELREIASEPVAEHYFYTADFKTINQIGKKLQKRICVEEDPCACESIVKFQTKVEGLLQALTRKHILSQKPLRGEGAVRRALWWRGGESLAPCVVGSGRLLLKTGWILAREAGLGFGTEKGEAETKS", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more VWF_A, EGF-like_dom, Matrilin_coiled-coil_trimer, EGF-like_dom, EGF-like_Ca-bd_dom, VWF_A, Matrilin_coiled-coil_trimer, VWF_A, VWF_A, VWF_A, VWF_A that are essential for its biological function; 2. The protein should belong to ECM_Assembly_Org that shares evolutionary origin and functional similarity; 3. The protein should be classified within vWFA_dom_sf, Matrilin_cc_sf, vWFA_dom_sf, vWFA_dom_sf, vWFA_dom_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MRALSGPRLMLCGLLLLLFQAPCALGLAPLSRGHLCRTRPTDLVFVVDSSRSVRPVEFEKVKVFLSQVIESLDVGPNATRVGLVNYASSVKQEFPLRAHSSKAELLQAVRRIQPLSTGTMTGLAIQFAITKALSDAEGGRPRSPDISKVVIVVTDGRPQDSVRDVSARARAGGIELFAIGVGRVDKATLQQIASEPQDEHVDYVESYSVIEKLSKKFQEAFCLVSDLCATGDHDCEQVCVSSPGSYTCACREGFTLNSDGKTCNVCNGGGGSSATDLVFLIDGSKSVRPENFELVKKFINQIVDTLDVSDKLAQVGLVQYSSSVRQEFPLGRFHTKKDIKAAVRNMSYMEKGTMTGAALKYLIDNSFTVSSGARPGAQKVGIVFTDGRSQDYINDAAKKAKDLGFKMFAVGVGNAVEDELREIASEPVAEHYFYTADFKTINQIGKKLQKRICVEEDPCACESIVKFQTKVEGLLQALTRKHILSQKPLRGEGAVRRALWWRGGESLAPCVVGSGRLLLKTGWILAREAGLGFGTEKGEAETKS" }, { "InterPro": [ { "InterPro-ID": "IPR003331", "InterPro-Name": "UDP_GlcNAc_Epimerase_2_dom", "InterPro-Type": "DOMAIN", "Beg": 25, "End": 374 }, { "InterPro-ID": "IPR029767", "InterPro-Name": "WecB-like", "InterPro-Type": "FAMILY", "Beg": 4, "End": 376 }, { "InterPro-ID": "IPR029767", "InterPro-Name": "WecB-like", "InterPro-Type": "FAMILY", "Beg": 3, "End": 378 } ], "response#1": "MVKKILIVFGTRPEAIKMAPLVKIMENRNDVNFRVCVTGQHRQMLDQILNIFDIKPDYDLNIMQENQDLYDITLKILCGMKNVLNDFKPNIVLVHGDTTTASVTALAAFYQKIKIAHVEAGLRTYNICNPWPEEANRQIIGVLANIHFTPTVKSAENLIKEGKNKEGIFITGNTVIDALFYMTEKIKNDKTFKIKVLSSIGNEYKINDNKKFILVTGHRRENFGEGFLQICEALKIIAINNPDIDIVYPVHLNPNVQKPVKMLLLNISNIYLINPLKYEEFIYLMSKSYFIITDSGGIQEEAPSLGKPILVMRETTERPEAVEAGVVKLVGACKQNIIRESQKLIDDQDEYEKMSKAYNPYGDGRACEKIINILIKGKNNESI", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more UDP_GlcNAc_Epimerase_2_dom that are essential for its biological function; 2. The protein should belong to WecB-like, WecB-like that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MVKKILIVFGTRPEAIKMAPLVKIMENRNDVNFRVCVTGQHRQMLDQILNIFDIKPDYDLNIMQENQDLYDITLKILCGMKNVLNDFKPNIVLVHGDTTTASVTALAAFYQKIKIAHVEAGLRTYNICNPWPEEANRQIIGVLANIHFTPTVKSAENLIKEGKNKEGIFITGNTVIDALFYMTEKIKNDKTFKIKVLSSIGNEYKINDNKKFILVTGHRRENFGEGFLQICEALKIIAINNPDIDIVYPVHLNPNVQKPVKMLLLNISNIYLINPLKYEEFIYLMSKSYFIITDSGGIQEEAPSLGKPILVMRETTERPEAVEAGVVKLVGACKQNIIRESQKLIDDQDEYEKMSKAYNPYGDGRACEKIINILIKGKNNESI" }, { "InterPro": [ { "InterPro-ID": "IPR001360", "InterPro-Name": "Glyco_hydro_1", "InterPro-Type": "FAMILY", "Beg": 22, "End": 515 }, { "InterPro-ID": "IPR001360", "InterPro-Name": "Glyco_hydro_1", "InterPro-Type": "FAMILY", "Beg": 232, "End": 514 }, { "InterPro-ID": "IPR001360", "InterPro-Name": "Glyco_hydro_1", "InterPro-Type": "FAMILY", "Beg": 20, "End": 201 }, { "InterPro-ID": "IPR017853", "InterPro-Name": "Glycoside_hydrolase_SF", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 17, "End": 511 }, { "InterPro-ID": "IPR001360", "InterPro-Name": "Glyco_hydro_1", "InterPro-Type": "FAMILY", "Beg": 462, "End": 479 }, { "InterPro-ID": "IPR001360", "InterPro-Name": "Glyco_hydro_1", "InterPro-Type": "FAMILY", "Beg": 341, "End": 355 }, { "InterPro-ID": "IPR001360", "InterPro-Name": "Glyco_hydro_1", "InterPro-Type": "FAMILY", "Beg": 486, "End": 498 }, { "InterPro-ID": "IPR001360", "InterPro-Name": "Glyco_hydro_1", "InterPro-Type": "FAMILY", "Beg": 418, "End": 426 }, { "InterPro-ID": "IPR001360", "InterPro-Name": "Glyco_hydro_1", "InterPro-Type": "FAMILY", "Beg": 441, "End": 452 }, { "InterPro-ID": "IPR033132", "InterPro-Name": "Glyco_hydro_1_N_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 26, "End": 40 } ], "response#1": "MSSVLPTPVLPTPGRNINRGHFPDDFIFGAGTSSYQIEGAAREGGRGPSIWDTFTHTHPELIQDGSNGDTAINSYNLYKEDIKIVKLMGLDAYRFSISWPRILPGGSINAGINQEGIKYYNNLIDELLANDIVPYVTLFHWDVPQALQDQYDGFLSDKIVDDFRDFAELCFWEFGDRVKNWITINEPESYSNFFGVAYDTPPKAHALKASRLLVPTTVARPSKPVRVFASTADPGTTTADQVYKVGHNLLLAHAAAIQVYRDKFQNTQEGTFGMALVTQWMKPLNENNPADVEAASRAFDFKFGWFMQPLITGEYPKSMRQLLGPRLREFTPDQKKLLIGSYDYVGVNYYTATYVSSAQPPHDKKKAVFHTDGNFYTTDSKDGVLIGPLAGPAWLNIVPEGIYHVLHDIKENYEDPVIYITENGVYEVNDTAKTLSEARVDTTRLHYLQDHLSKVLEARHQGVRVQGYLVWSLMDNWELRAGYTSRFGLIHVDYYNNFARYPKDSAIWFRNAFHKRLRIHVNKARPQEDDGAFDTPRKRLRKY", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Glyco_hydro_1, Glyco_hydro_1, Glyco_hydro_1, Glyco_hydro_1, Glyco_hydro_1, Glyco_hydro_1, Glyco_hydro_1, Glyco_hydro_1 that shares evolutionary origin and functional similarity; 2. The protein should be classified within Glycoside_hydrolase_SF sharing conserved structural features; 3. The protein should contain Glyco_hydro_1_N_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MSSVLPTPVLPTPGRNINRGHFPDDFIFGAGTSSYQIEGAAREGGRGPSIWDTFTHTHPELIQDGSNGDTAINSYNLYKEDIKIVKLMGLDAYRFSISWPRILPGGSINAGINQEGIKYYNNLIDELLANDIVPYVTLFHWDVPQALQDQYDGFLSDKIVDDFRDFAELCFWEFGDRVKNWITINEPESYSNFFGVAYDTPPKAHALKASRLLVPTTVARPSKPVRVFASTADPGTTTADQVYKVGHNLLLAHAAAIQVYRDKFQNTQEGTFGMALVTQWMKPLNENNPADVEAASRAFDFKFGWFMQPLITGEYPKSMRQLLGPRLREFTPDQKKLLIGSYDYVGVNYYTATYVSSAQPPHDKKKAVFHTDGNFYTTDSKDGVLIGPLAGPAWLNIVPEGIYHVLHDIKENYEDPVIYITENGVYEVNDTAKTLSEARVDTTRLHYLQDHLSKVLEARHQGVRVQGYLVWSLMDNWELRAGYTSRFGLIHVDYYNNFARYPKDSAIWFRNAFHKRLRIHVNKARPQEDDGAFDTPRKRLRKY" }, { "InterPro": [ { "InterPro-ID": "IPR008030", "InterPro-Name": "NmrA-like", "InterPro-Type": "DOMAIN", "Beg": 4, "End": 304 }, { "InterPro-ID": "IPR051164", "InterPro-Name": "NmrA-like_oxidored", "InterPro-Type": "FAMILY", "Beg": 5, "End": 293 }, { "InterPro-ID": "IPR036291", "InterPro-Name": "NAD(P)-bd_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 5, "End": 293 } ], "response#1": "MTFIIAVVGATGNQGGSVARSLVQNPSFSVRAITRSPDSQASRSLLSAGAEVVKADGFNGEEMLAAFQGAWGAFVNLNSDDPIWRQPGGPTEFDLGKTIVDAAAGAGVKHLVFSSGPPCVEMTGGKVNMKAMEMKYKIEQYARKLGSFETLTPINPAWYLENFLAEEVAPIFGGFPYFPDEEGYLTFRVPHWAGPGGDNRVPFLGIRDDFGDIIHGIFLNPERYNGRVIHGVSQLRGFDELVADFEQVTGKKCRYEPVLPSWEAFDIHGIPELEDVKLMFAFTQTTGGRYFAPEPSEADTAAELKRTTAVALGKPEPEQHTLRTKDFFRKHFATEK", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more NmrA-like that are essential for its biological function; 2. The protein should belong to NmrA-like_oxidored that shares evolutionary origin and functional similarity; 3. The protein should be classified within NAD(P)-bd_dom_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MTFIIAVVGATGNQGGSVARSLVQNPSFSVRAITRSPDSQASRSLLSAGAEVVKADGFNGEEMLAAFQGAWGAFVNLNSDDPIWRQPGGPTEFDLGKTIVDAAAGAGVKHLVFSSGPPCVEMTGGKVNMKAMEMKYKIEQYARKLGSFETLTPINPAWYLENFLAEEVAPIFGGFPYFPDEEGYLTFRVPHWAGPGGDNRVPFLGIRDDFGDIIHGIFLNPERYNGRVIHGVSQLRGFDELVADFEQVTGKKCRYEPVLPSWEAFDIHGIPELEDVKLMFAFTQTTGGRYFAPEPSEADTAAELKRTTAVALGKPEPEQHTLRTKDFFRKHFATEK" }, { "InterPro": [ { "InterPro-ID": "IPR010636", "InterPro-Name": "Cerato-ulmin_hydrophobin", "InterPro-Type": "FAMILY", "Beg": 2, "End": 101 }, { "InterPro-ID": "IPR010636", "InterPro-Name": "Cerato-ulmin_hydrophobin", "InterPro-Type": "FAMILY", "Beg": 38, "End": 100 }, { "InterPro-ID": "IPR036686", "InterPro-Name": "Hydrophobin_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 31, "End": 104 }, { "InterPro-ID": "IPR010636", "InterPro-Name": "Cerato-ulmin_hydrophobin", "InterPro-Type": "FAMILY", "Beg": 36, "End": 101 }, { "InterPro-ID": "IPR036686", "InterPro-Name": "Hydrophobin_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 36, "End": 103 } ], "response#1": "MQFFTVATLFLATAFAAPSVDTNGNGIAPRLAANFCPPGLLYSNPQCCQIDVLGVADLDCVSPPSGPSKCKTFAGICDKIGRQPKCCVVPVAGQALLCTDPVGANN", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Cerato-ulmin_hydrophobin, Cerato-ulmin_hydrophobin, Cerato-ulmin_hydrophobin that shares evolutionary origin and functional similarity; 2. The protein should be classified within Hydrophobin_sf, Hydrophobin_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MQFFTVATLFLATAFAAPSVDTNGNGIAPRLAANFCPPGLLYSNPQCCQIDVLGVADLDCVSPPSGPSKCKTFAGICDKIGRQPKCCVVPVAGQALLCTDPVGANN" }, { "InterPro": [ { "InterPro-ID": "IPR027381", "InterPro-Name": "LytR/CpsA/Psr_C", "InterPro-Type": "DOMAIN", "Beg": 90, "End": 179 } ], "response#1": "MVAQITEGTAFDKHGRPFRRRNPRPAIVVVAFLVVVTCVMWTLALTRPPDVREAAVCNPPPQPAGSAPTNLGEQVSRTDMTDVAPAKLSDTKVHVLNASGRGGQAADIAGALQDLGFAQPTAANDPIYAGTRLDCQGQIRFGTAGQATAAALWLVAPCTELYHDSRADDSVDLALGTDFTTLAHNDDIDAVLANLRPGATEPSDPALLAKIHANSC", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more LytR/CpsA/Psr_C that are essential for its biological function. The designed protein sequence is ", "reference": "MVAQITEGTAFDKHGRPFRRRNPRPAIVVVAFLVVVTCVMWTLALTRPPDVREAAVCNPPPQPAGSAPTNLGEQVSRTDMTDVAPAKLSDTKVHVLNASGRGGQAADIAGALQDLGFAQPTAANDPIYAGTRLDCQGQIRFGTAGQATAAALWLVAPCTELYHDSRADDSVDLALGTDFTTLAHNDDIDAVLANLRPGATEPSDPALLAKIHANSC" }, { "InterPro": [ { "InterPro-ID": "IPR002129", "InterPro-Name": "PyrdxlP-dep_de-COase", "InterPro-Type": "FAMILY", "Beg": 52, "End": 425 }, { "InterPro-ID": "IPR015422", "InterPro-Name": "PyrdxlP-dep_Trfase_small", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 392, "End": 520 }, { "InterPro-ID": "IPR010977", "InterPro-Name": "Aromatic_deC", "InterPro-Type": "FAMILY", "Beg": 130, "End": 149 }, { "InterPro-ID": "IPR010977", "InterPro-Name": "Aromatic_deC", "InterPro-Type": "FAMILY", "Beg": 23, "End": 42 }, { "InterPro-ID": "IPR010977", "InterPro-Name": "Aromatic_deC", "InterPro-Type": "FAMILY", "Beg": 407, "End": 426 }, { "InterPro-ID": "IPR010977", "InterPro-Name": "Aromatic_deC", "InterPro-Type": "FAMILY", "Beg": 111, "End": 129 }, { "InterPro-ID": "IPR010977", "InterPro-Name": "Aromatic_deC", "InterPro-Type": "FAMILY", "Beg": 64, "End": 83 }, { "InterPro-ID": "IPR010977", "InterPro-Name": "Aromatic_deC", "InterPro-Type": "FAMILY", "Beg": 46, "End": 63 }, { "InterPro-ID": "IPR010977", "InterPro-Name": "Aromatic_deC", "InterPro-Type": "FAMILY", "Beg": 90, "End": 109 }, { "InterPro-ID": "IPR010977", "InterPro-Name": "Aromatic_deC", "InterPro-Type": "FAMILY", "Beg": 155, "End": 175 }, { "InterPro-ID": "IPR010977", "InterPro-Name": "Aromatic_deC", "InterPro-Type": "FAMILY", "Beg": 364, "End": 379 }, { "InterPro-ID": "IPR015424", "InterPro-Name": "PyrdxlP-dep_Trfase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 19, "End": 508 }, { "InterPro-ID": "IPR021115", "InterPro-Name": "Pyridoxal-P_BS", "InterPro-Type": "BINDING_SITE", "Beg": 308, "End": 329 }, { "InterPro-ID": "IPR015421", "InterPro-Name": "PyrdxlP-dep_Trfase_major", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 100, "End": 391 } ], "response#1": "MGSLDIKQESSPLMTNPLDSEEFRRQGYMVIDFLAEYYKNIQKFPVRSQVEPGYLRKRLPESAPYEPESIETILKDVHDDIVPGLTHWQSPNYYAYFPSSGSTAGLLGETLAAGFNVVGFNWISSPASTELESIVMDWLAEMLNLPKSFTFSGDGGGVMMGTTCEAILTTITAARDRILDRIGREHINKLVVYGSDQTHCSFFKSAKIAGISPNNFRQVKTSRVNAFSMRPDALRAAIQADVDAGLVPFFLCTTVGTTSTAAVDPVALLCEVAKDYGMWVHIDAAYAGNACICPEFRHMINGVENADSFSFNAHKWFLTTLDCCCLWVKDPSSLVRCLSTNPEYLKNKATDTQQVVDYKDWQITLSRRFRSLKMWLVLRSYGVDYLRNFLRSHVDMAAYFEQLVRMDGRFEVVVPRSFALVCFRLSASAVIQRLYDSCHRHGHGQKFLEEETLNDVNAELLESVNSAGQIYMTHSLVDGVYMLRFAVGATLTQTHHVTYAWKQVQDHASAVLARRINSICNC", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to PyrdxlP-dep_de-COase, Aromatic_deC, Aromatic_deC, Aromatic_deC, Aromatic_deC, Aromatic_deC, Aromatic_deC, Aromatic_deC, Aromatic_deC, Aromatic_deC that shares evolutionary origin and functional similarity; 2. The protein should be classified within PyrdxlP-dep_Trfase_small, PyrdxlP-dep_Trfase, PyrdxlP-dep_Trfase_major sharing conserved structural features; 3. The protein should include a Pyridoxal-P_BS that enables ligand binding under diverse conditions. The designed protein sequence is ", "reference": "MGSLDIKQESSPLMTNPLDSEEFRRQGYMVIDFLAEYYKNIQKFPVRSQVEPGYLRKRLPESAPYEPESIETILKDVHDDIVPGLTHWQSPNYYAYFPSSGSTAGLLGETLAAGFNVVGFNWISSPASTELESIVMDWLAEMLNLPKSFTFSGDGGGVMMGTTCEAILTTITAARDRILDRIGREHINKLVVYGSDQTHCSFFKSAKIAGISPNNFRQVKTSRVNAFSMRPDALRAAIQADVDAGLVPFFLCTTVGTTSTAAVDPVALLCEVAKDYGMWVHIDAAYAGNACICPEFRHMINGVENADSFSFNAHKWFLTTLDCCCLWVKDPSSLVRCLSTNPEYLKNKATDTQQVVDYKDWQITLSRRFRSLKMWLVLRSYGVDYLRNFLRSHVDMAAYFEQLVRMDGRFEVVVPRSFALVCFRLSASAVIQRLYDSCHRHGHGQKFLEEETLNDVNAELLESVNSAGQIYMTHSLVDGVYMLRFAVGATLTQTHHVTYAWKQVQDHASAVLARRINSICNC" }, { "InterPro": [ { "InterPro-ID": "IPR036396", "InterPro-Name": "Cyt_P450_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 17, "End": 495 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 312, "End": 434 }, { "InterPro-ID": "IPR036396", "InterPro-Name": "Cyt_P450_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 17, "End": 479 }, { "InterPro-ID": "IPR002403", "InterPro-Name": "Cyt_P450_E_grp-IV", "InterPro-Type": "FAMILY", "Beg": 399, "End": 417 }, { "InterPro-ID": "IPR002403", "InterPro-Name": "Cyt_P450_E_grp-IV", "InterPro-Type": "FAMILY", "Beg": 346, "End": 362 } ], "response#1": "MSKPAAAAPSDPSKPSKPLKEVPGSYGLPVLGAVKDRLDFYWFQGDTEFFRIRMEQHKSTVFRVNYSPGPPGYPDSRGIILLDQKSFSVLLDNSKVDKSDTLLGPYIPNLAFTGGYRVLPYLDTSEAKHTAYKDLIFELLHVNSSRIIPEYNKVFAETAGSWEERIAKSGKAEVFASSDSMITKFLLRTIVHKDPAEPGPASLGPKFRDTYQLWTGVNFAGIAHTPLPHFLEELLFHTFRLPPFLVKKQYKALANFYRTHATEVLDLAEKKYGLDREETVHQLILILGINARLGLHKMIPALIYYLGLLGEDFQAKIAAEVRSAVHKNRAQGEEGVNITTQALLEMPLLRSTVLETLRLTPSIFYIYGRAREDMVIESHDAAFQIKKGELLGGHQYFVMRDPEVFEEPHKFVADRFLGERGKAVLPYLVWSNGRETESPSSSNKQCPAKDVAELITMQFVAEMFLRYDSFEITKDSFINTTELNVHLKSLKKRSV", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Cyt_P450, Cyt_P450_E_grp-IV, Cyt_P450_E_grp-IV that shares evolutionary origin and functional similarity; 2. The protein should be classified within Cyt_P450_sf, Cyt_P450_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MSKPAAAAPSDPSKPSKPLKEVPGSYGLPVLGAVKDRLDFYWFQGDTEFFRIRMEQHKSTVFRVNYSPGPPGYPDSRGIILLDQKSFSVLLDNSKVDKSDTLLGPYIPNLAFTGGYRVLPYLDTSEAKHTAYKDLIFELLHVNSSRIIPEYNKVFAETAGSWEERIAKSGKAEVFASSDSMITKFLLRTIVHKDPAEPGPASLGPKFRDTYQLWTGVNFAGIAHTPLPHFLEELLFHTFRLPPFLVKKQYKALANFYRTHATEVLDLAEKKYGLDREETVHQLILILGINARLGLHKMIPALIYYLGLLGEDFQAKIAAEVRSAVHKNRAQGEEGVNITTQALLEMPLLRSTVLETLRLTPSIFYIYGRAREDMVIESHDAAFQIKKGELLGGHQYFVMRDPEVFEEPHKFVADRFLGERGKAVLPYLVWSNGRETESPSSSNKQCPAKDVAELITMQFVAEMFLRYDSFEITKDSFINTTELNVHLKSLKKRSV" }, { "InterPro": [ { "InterPro-ID": "IPR018333", "InterPro-Name": "Squalene_cyclase", "InterPro-Type": "FAMILY", "Beg": 1, "End": 755 }, { "InterPro-ID": "IPR032697", "InterPro-Name": "SQ_cyclase_N", "InterPro-Type": "DOMAIN", "Beg": 99, "End": 302 }, { "InterPro-ID": "IPR018333", "InterPro-Name": "Squalene_cyclase", "InterPro-Type": "FAMILY", "Beg": 97, "End": 752 }, { "InterPro-ID": "IPR032696", "InterPro-Name": "SQ_cyclase_C", "InterPro-Type": "DOMAIN", "Beg": 417, "End": 752 }, { "InterPro-ID": "IPR008930", "InterPro-Name": "Terpenoid_cyclase/PrenylTrfase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 351, "End": 755 }, { "InterPro-ID": "IPR018333", "InterPro-Name": "Squalene_cyclase", "InterPro-Type": "FAMILY", "Beg": 91, "End": 754 }, { "InterPro-ID": "IPR018333", "InterPro-Name": "Squalene_cyclase", "InterPro-Type": "FAMILY", "Beg": 98, "End": 751 }, { "InterPro-ID": "IPR008930", "InterPro-Name": "Terpenoid_cyclase/PrenylTrfase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 121, "End": 410 } ], "response#1": "MWRLKIAEGGNDPYLYSTNNFVGRQTWEFDSEYGTPEAIKEVEEARQIFYKNRFQVKPCGDLLWRFQFLREKNFKQTIPQVKVGDGEEVTYEAASTTLKRSVNLLTALQADDGHWPAEIAGPQFFLPPLVFCLYITGHLNVVFNVHHREEILRSIYYHQNEDGGWGLHIEGHSTMFCTALNYICLRMLGVGPDEGDDNACPRARKWILDHGSVTHIPSWGKTWLSILGLFDWSGSNPMPPEFWILPTFMPMYPAKMWCYCRMVYMPMSYLYGKRFVGPITPLIKQLREELFSEPFEEIKWKKVRHLCAPEDLYYPHPLIQDLMWDSLYLFTEPLLTRWPFNNLIRQKALQVTMDHIHYEDENSRYITIGCVEKVLCMLACWVEDPNGVCYKKHLARVPDYIWIAEDGLKMQSFGSQQWDCGFAVQALLASNMSLDEIGPALKKGHFFIKESQVKDNPSGDFKSMHRHISKGSWTFSDQDHGWQVSDCTAEGLKCCLILSTMPPEIVGEKMDPERLYDSVNVLLSLQSENGGLSAWEPAGAQAWLELLNPTEFFADIVIEHEYVECTGASIQALVLFKKMYPGHRKKEIENFIAKAAKYLEDTQYPNGSWYGNWGVCFTYGTWFALGGLAAAGKTYANCAAMRKGVEFLLKSQKEDGGWGESYVSCPKKDFVPLEGPSNLTQTAWALMGLIYARQMERDPTPLHQAAKLLINSQLENGDFPQQEITGVFMKNCMLHYPMYRTIYPLWAIAEYRTHVPLRLS", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more SQ_cyclase_N, SQ_cyclase_C that are essential for its biological function; 2. The protein should belong to Squalene_cyclase, Squalene_cyclase, Squalene_cyclase, Squalene_cyclase that shares evolutionary origin and functional similarity; 3. The protein should be classified within Terpenoid_cyclase/PrenylTrfase, Terpenoid_cyclase/PrenylTrfase sharing conserved structural features. The designed protein sequence is ", "reference": "MWRLKIAEGGNDPYLYSTNNFVGRQTWEFDSEYGTPEAIKEVEEARQIFYKNRFQVKPCGDLLWRFQFLREKNFKQTIPQVKVGDGEEVTYEAASTTLKRSVNLLTALQADDGHWPAEIAGPQFFLPPLVFCLYITGHLNVVFNVHHREEILRSIYYHQNEDGGWGLHIEGHSTMFCTALNYICLRMLGVGPDEGDDNACPRARKWILDHGSVTHIPSWGKTWLSILGLFDWSGSNPMPPEFWILPTFMPMYPAKMWCYCRMVYMPMSYLYGKRFVGPITPLIKQLREELFSEPFEEIKWKKVRHLCAPEDLYYPHPLIQDLMWDSLYLFTEPLLTRWPFNNLIRQKALQVTMDHIHYEDENSRYITIGCVEKVLCMLACWVEDPNGVCYKKHLARVPDYIWIAEDGLKMQSFGSQQWDCGFAVQALLASNMSLDEIGPALKKGHFFIKESQVKDNPSGDFKSMHRHISKGSWTFSDQDHGWQVSDCTAEGLKCCLILSTMPPEIVGEKMDPERLYDSVNVLLSLQSENGGLSAWEPAGAQAWLELLNPTEFFADIVIEHEYVECTGASIQALVLFKKMYPGHRKKEIENFIAKAAKYLEDTQYPNGSWYGNWGVCFTYGTWFALGGLAAAGKTYANCAAMRKGVEFLLKSQKEDGGWGESYVSCPKKDFVPLEGPSNLTQTAWALMGLIYARQMERDPTPLHQAAKLLINSQLENGDFPQQEITGVFMKNCMLHYPMYRTIYPLWAIAEYRTHVPLRLS" }, { "InterPro": [ { "InterPro-ID": "IPR002213", "InterPro-Name": "UDP_glucos_trans", "InterPro-Type": "FAMILY", "Beg": 281, "End": 403 }, { "InterPro-ID": "IPR002213", "InterPro-Name": "UDP_glucos_trans", "InterPro-Type": "FAMILY", "Beg": 15, "End": 465 } ], "response#1": "MGSNTEATEIPKMPLKIVFLTLPIAGHMLHIVDTASTFAIHGVECTIITTPANVPFIEKSISATNTTIRQFLSIRLVDFPHEAVGLPPGVENFSAVTCPDMRPKISKGLSIIQKPTEDLIKEISPDCIVSDMFYPWTSDFALEIGVPRVVFRGCGMFPMCCWHSIKSHLPHEKVDRDDEMIVLPTLPDHIEMRKSTLPDWVRKPTGYSYLMKMIDAAELKSYGVIVNSFSDLERDYEEYFKNVTGLKVWTVGPISLHVGRNEELEGSDEWVKWLDGKKLDSVIYVSFGGVAKFPPHQLREIAAGLESSGHDFVWVVRASDENGDQAEADEWSLQKFKEKMKKTNHGLVIESWVPQLMFLEHKAIGGMLTHVGWGTMLEGITAGLPLVTWPLYAEQFYNERLVVDVLKIGVGVGVKEFCGLDDIGKKETIGRENIEASVRLVMGDGEEAAAMRLRVKELSEASMKAVREGGSSKANIHDFLNELSTLRSLRQA", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to UDP_glucos_trans, UDP_glucos_trans that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MGSNTEATEIPKMPLKIVFLTLPIAGHMLHIVDTASTFAIHGVECTIITTPANVPFIEKSISATNTTIRQFLSIRLVDFPHEAVGLPPGVENFSAVTCPDMRPKISKGLSIIQKPTEDLIKEISPDCIVSDMFYPWTSDFALEIGVPRVVFRGCGMFPMCCWHSIKSHLPHEKVDRDDEMIVLPTLPDHIEMRKSTLPDWVRKPTGYSYLMKMIDAAELKSYGVIVNSFSDLERDYEEYFKNVTGLKVWTVGPISLHVGRNEELEGSDEWVKWLDGKKLDSVIYVSFGGVAKFPPHQLREIAAGLESSGHDFVWVVRASDENGDQAEADEWSLQKFKEKMKKTNHGLVIESWVPQLMFLEHKAIGGMLTHVGWGTMLEGITAGLPLVTWPLYAEQFYNERLVVDVLKIGVGVGVKEFCGLDDIGKKETIGRENIEASVRLVMGDGEEAAAMRLRVKELSEASMKAVREGGSSKANIHDFLNELSTLRSLRQA" }, { "InterPro": [ { "InterPro-ID": "IPR036736", "InterPro-Name": "ACP-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 6390, "End": 6461 }, { "InterPro-ID": "IPR029058", "InterPro-Name": "AB_hydrolase_fold", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 7428, "End": 7773 }, { "InterPro-ID": "IPR023213", "InterPro-Name": "CAT-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 5094, "End": 5458 }, { "InterPro-ID": "IPR006162", "InterPro-Name": "Ppantetheine_attach_site", "InterPro-Type": "PTM", "Beg": 5032, "End": 5047 }, { "InterPro-ID": "IPR020845", "InterPro-Name": "AMP-binding_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 2607, "End": 2618 }, { "InterPro-ID": "IPR045851", "InterPro-Name": "AMP-bd_C_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1428, "End": 1501 }, { "InterPro-ID": "IPR045851", "InterPro-Name": "AMP-bd_C_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 5922, "End": 5995 }, { "InterPro-ID": "IPR009081", "InterPro-Name": "PP-bd_ACP", "InterPro-Type": "DOMAIN", "Beg": 1908, "End": 1983 }, { "InterPro-ID": "IPR029063", "InterPro-Name": "SAM-dependent_MTases_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 6004, "End": 6173 }, { "InterPro-ID": "IPR006162", "InterPro-Name": "Ppantetheine_attach_site", "InterPro-Type": "PTM", "Beg": 6419, "End": 6434 }, { "InterPro-ID": "IPR010071", "InterPro-Name": "AA_adenyl_dom", "InterPro-Type": "DOMAIN", "Beg": 2487, "End": 2880 }, { "InterPro-ID": "IPR010071", "InterPro-Name": "AA_adenyl_dom", "InterPro-Type": "DOMAIN", "Beg": 3536, "End": 3906 }, { "InterPro-ID": "IPR010071", "InterPro-Name": "AA_adenyl_dom", "InterPro-Type": "DOMAIN", "Beg": 1062, "End": 1458 }, { "InterPro-ID": "IPR010071", "InterPro-Name": "AA_adenyl_dom", "InterPro-Type": "DOMAIN", "Beg": 4552, "End": 4926 }, { "InterPro-ID": "IPR010071", "InterPro-Name": "AA_adenyl_dom", "InterPro-Type": "DOMAIN", "Beg": 35, "End": 410 }, { "InterPro-ID": "IPR010071", "InterPro-Name": "AA_adenyl_dom", "InterPro-Type": "DOMAIN", "Beg": 6956, "End": 7356 }, { "InterPro-ID": "IPR010071", "InterPro-Name": "AA_adenyl_dom", "InterPro-Type": "DOMAIN", "Beg": 5578, "End": 5952 }, { "InterPro-ID": "IPR009081", "InterPro-Name": "PP-bd_ACP", "InterPro-Type": "DOMAIN", "Beg": 7432, "End": 7507 }, { "InterPro-ID": "IPR036736", "InterPro-Name": "ACP-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 6383, "End": 6465 }, { "InterPro-ID": "IPR036736", "InterPro-Name": "ACP-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1905, "End": 1986 }, { "InterPro-ID": "IPR036736", "InterPro-Name": "ACP-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 482, "End": 564 }, { "InterPro-ID": "IPR036736", "InterPro-Name": "ACP-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 4998, "End": 5078 }, { "InterPro-ID": "IPR045851", "InterPro-Name": "AMP-bd_C_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 380, "End": 481 }, { "InterPro-ID": "IPR045851", "InterPro-Name": "AMP-bd_C_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 7326, "End": 7427 }, { "InterPro-ID": "IPR045851", "InterPro-Name": "AMP-bd_C_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 4896, "End": 4997 }, { "InterPro-ID": "IPR020806", "InterPro-Name": "PKS_PP-bd", "InterPro-Type": "DOMAIN", "Beg": 3984, "End": 4053 }, { "InterPro-ID": "IPR020806", "InterPro-Name": "PKS_PP-bd", "InterPro-Type": "DOMAIN", "Beg": 1914, "End": 1983 }, { "InterPro-ID": "IPR020806", "InterPro-Name": "PKS_PP-bd", "InterPro-Type": "DOMAIN", "Beg": 493, "End": 562 }, { "InterPro-ID": "IPR020806", "InterPro-Name": "PKS_PP-bd", "InterPro-Type": "DOMAIN", "Beg": 7438, "End": 7507 }, { "InterPro-ID": "IPR020806", "InterPro-Name": "PKS_PP-bd", "InterPro-Type": "DOMAIN", "Beg": 5008, "End": 5077 }, { "InterPro-ID": "IPR020806", "InterPro-Name": "PKS_PP-bd", "InterPro-Type": "DOMAIN", "Beg": 6395, "End": 6464 }, { "InterPro-ID": "IPR020806", "InterPro-Name": "PKS_PP-bd", "InterPro-Type": "DOMAIN", "Beg": 2964, "End": 3033 }, { "InterPro-ID": "IPR045851", "InterPro-Name": "AMP-bd_C_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 3876, "End": 3969 }, { "InterPro-ID": "IPR020845", "InterPro-Name": "AMP-binding_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 7083, "End": 7094 }, { "InterPro-ID": "IPR020845", "InterPro-Name": "AMP-binding_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 1185, "End": 1196 }, { "InterPro-ID": "IPR023213", "InterPro-Name": "CAT-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 580, "End": 952 }, { "InterPro-ID": "IPR020845", "InterPro-Name": "AMP-binding_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 4653, "End": 4664 }, { "InterPro-ID": "IPR009081", "InterPro-Name": "PP-bd_ACP", "InterPro-Type": "DOMAIN", "Beg": 3986, "End": 4046 }, { "InterPro-ID": "IPR009081", "InterPro-Name": "PP-bd_ACP", "InterPro-Type": "DOMAIN", "Beg": 2966, "End": 3027 }, { "InterPro-ID": "IPR009081", "InterPro-Name": "PP-bd_ACP", "InterPro-Type": "DOMAIN", "Beg": 1916, "End": 1976 }, { "InterPro-ID": "IPR009081", "InterPro-Name": "PP-bd_ACP", "InterPro-Type": "DOMAIN", "Beg": 5010, "End": 5072 }, { "InterPro-ID": "IPR009081", "InterPro-Name": "PP-bd_ACP", "InterPro-Type": "DOMAIN", "Beg": 7440, "End": 7502 }, { "InterPro-ID": "IPR009081", "InterPro-Name": "PP-bd_ACP", "InterPro-Type": "DOMAIN", "Beg": 6397, "End": 6459 }, { "InterPro-ID": "IPR009081", "InterPro-Name": "PP-bd_ACP", "InterPro-Type": "DOMAIN", "Beg": 496, "End": 558 }, { "InterPro-ID": "IPR001242", "InterPro-Name": "Condensatn", "InterPro-Type": "DOMAIN", "Beg": 4068, "End": 4512 }, { "InterPro-ID": "IPR001242", "InterPro-Name": "Condensatn", "InterPro-Type": "DOMAIN", "Beg": 3048, "End": 3495 }, { "InterPro-ID": "IPR001242", "InterPro-Name": "Condensatn", "InterPro-Type": "DOMAIN", "Beg": 5093, "End": 5537 }, { "InterPro-ID": "IPR001242", "InterPro-Name": "Condensatn", "InterPro-Type": "DOMAIN", "Beg": 578, "End": 1020 }, { "InterPro-ID": "IPR001242", "InterPro-Name": "Condensatn", "InterPro-Type": "DOMAIN", "Beg": 6479, "End": 6919 }, { "InterPro-ID": "IPR001242", "InterPro-Name": "Condensatn", "InterPro-Type": "DOMAIN", "Beg": 1998, "End": 2445 }, { "InterPro-ID": "IPR036736", "InterPro-Name": "ACP-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 7432, "End": 7503 }, { "InterPro-ID": "IPR023213", "InterPro-Name": "CAT-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 4070, "End": 4440 }, { "InterPro-ID": "IPR036736", "InterPro-Name": "ACP-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 3977, "End": 4049 }, { "InterPro-ID": "IPR020845", "InterPro-Name": "AMP-binding_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 5679, "End": 5690 }, { "InterPro-ID": "IPR009081", "InterPro-Name": "PP-bd_ACP", "InterPro-Type": "DOMAIN", "Beg": 6389, "End": 6464 }, { "InterPro-ID": "IPR023213", "InterPro-Name": "CAT-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 2000, "End": 2369 }, { "InterPro-ID": "IPR029058", "InterPro-Name": "AB_hydrolase_fold", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 7506, "End": 7771 }, { "InterPro-ID": "IPR023213", "InterPro-Name": "CAT-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 3049, "End": 3419 }, { "InterPro-ID": "IPR029063", "InterPro-Name": "SAM-dependent_MTases_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1524, "End": 1685 }, { "InterPro-ID": "IPR029063", "InterPro-Name": "SAM-dependent_MTases_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 6016, "End": 6168 }, { "InterPro-ID": "IPR023213", "InterPro-Name": "CAT-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 6481, "End": 6853 }, { "InterPro-ID": "IPR000873", "InterPro-Name": "AMP-dep_synth/lig_dom", "InterPro-Type": "DOMAIN", "Beg": 6935, "End": 7282 }, { "InterPro-ID": "IPR000873", "InterPro-Name": "AMP-dep_synth/lig_dom", "InterPro-Type": "DOMAIN", "Beg": 5557, "End": 5877 }, { "InterPro-ID": "IPR000873", "InterPro-Name": "AMP-dep_synth/lig_dom", "InterPro-Type": "DOMAIN", "Beg": 1041, "End": 1384 }, { "InterPro-ID": "IPR000873", "InterPro-Name": "AMP-dep_synth/lig_dom", "InterPro-Type": "DOMAIN", "Beg": 15, "End": 336 }, { "InterPro-ID": "IPR000873", "InterPro-Name": "AMP-dep_synth/lig_dom", "InterPro-Type": "DOMAIN", "Beg": 3515, "End": 3831 }, { "InterPro-ID": "IPR000873", "InterPro-Name": "AMP-dep_synth/lig_dom", "InterPro-Type": "DOMAIN", "Beg": 2466, "End": 2806 }, { "InterPro-ID": "IPR000873", "InterPro-Name": "AMP-dep_synth/lig_dom", "InterPro-Type": "DOMAIN", "Beg": 4531, "End": 4852 }, { "InterPro-ID": "IPR009081", "InterPro-Name": "PP-bd_ACP", "InterPro-Type": "DOMAIN", "Beg": 2958, "End": 3033 }, { "InterPro-ID": "IPR006162", "InterPro-Name": "Ppantetheine_attach_site", "InterPro-Type": "PTM", "Beg": 7462, "End": 7477 }, { "InterPro-ID": "IPR045851", "InterPro-Name": "AMP-bd_C_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1800, "End": 1904 }, { "InterPro-ID": "IPR045851", "InterPro-Name": "AMP-bd_C_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 6297, "End": 6382 }, { "InterPro-ID": "IPR036736", "InterPro-Name": "ACP-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1909, "End": 1979 }, { "InterPro-ID": "IPR042099", "InterPro-Name": "ANL_N_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 6929, "End": 7325 }, { "InterPro-ID": "IPR042099", "InterPro-Name": "ANL_N_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 7, "End": 379 }, { "InterPro-ID": "IPR042099", "InterPro-Name": "ANL_N_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 4524, "End": 4895 }, { "InterPro-ID": "IPR042099", "InterPro-Name": "ANL_N_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 3508, "End": 3875 }, { "InterPro-ID": "IPR042099", "InterPro-Name": "ANL_N_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 5550, "End": 5921 }, { "InterPro-ID": "IPR009081", "InterPro-Name": "PP-bd_ACP", "InterPro-Type": "DOMAIN", "Beg": 3978, "End": 4053 }, { "InterPro-ID": "IPR020845", "InterPro-Name": "AMP-binding_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 3637, "End": 3648 }, { "InterPro-ID": "IPR036736", "InterPro-Name": "ACP-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 489, "End": 592 }, { "InterPro-ID": "IPR001031", "InterPro-Name": "Thioesterase", "InterPro-Type": "DOMAIN", "Beg": 7525, "End": 7759 }, { "InterPro-ID": "IPR020845", "InterPro-Name": "AMP-binding_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 137, "End": 148 }, { "InterPro-ID": "IPR020802", "InterPro-Name": "PKS_thioesterase", "InterPro-Type": "DOMAIN", "Beg": 7528, "End": 7771 }, { "InterPro-ID": "IPR036736", "InterPro-Name": "ACP-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 5001, "End": 5073 }, { "InterPro-ID": "IPR006162", "InterPro-Name": "Ppantetheine_attach_site", "InterPro-Type": "PTM", "Beg": 2988, "End": 3003 }, { "InterPro-ID": "IPR009081", "InterPro-Name": "PP-bd_ACP", "InterPro-Type": "DOMAIN", "Beg": 5002, "End": 5077 }, { "InterPro-ID": "IPR036736", "InterPro-Name": "ACP-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 2951, "End": 3033 }, { "InterPro-ID": "IPR036736", "InterPro-Name": "ACP-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 3970, "End": 4059 }, { "InterPro-ID": "IPR009081", "InterPro-Name": "PP-bd_ACP", "InterPro-Type": "DOMAIN", "Beg": 487, "End": 562 }, { "InterPro-ID": "IPR025110", "InterPro-Name": "AMP-bd_C", "InterPro-Type": "DOMAIN", "Beg": 3890, "End": 3960 }, { "InterPro-ID": "IPR025110", "InterPro-Name": "AMP-bd_C", "InterPro-Type": "DOMAIN", "Beg": 7340, "End": 7414 }, { "InterPro-ID": "IPR025110", "InterPro-Name": "AMP-bd_C", "InterPro-Type": "DOMAIN", "Beg": 2864, "End": 2938 }, { "InterPro-ID": "IPR025110", "InterPro-Name": "AMP-bd_C", "InterPro-Type": "DOMAIN", "Beg": 394, "End": 468 }, { "InterPro-ID": "IPR025110", "InterPro-Name": "AMP-bd_C", "InterPro-Type": "DOMAIN", "Beg": 4910, "End": 4984 }, { "InterPro-ID": "IPR029063", "InterPro-Name": "SAM-dependent_MTases_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1490, "End": 1670 }, { "InterPro-ID": "IPR013217", "InterPro-Name": "Methyltransf_12", "InterPro-Type": "DOMAIN", "Beg": 1547, "End": 1645 }, { "InterPro-ID": "IPR013217", "InterPro-Name": "Methyltransf_12", "InterPro-Type": "DOMAIN", "Beg": 6042, "End": 6140 }, { "InterPro-ID": "IPR045851", "InterPro-Name": "AMP-bd_C_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 2849, "End": 2950 }, { "InterPro-ID": "IPR036736", "InterPro-Name": "ACP-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 2964, "End": 3061 } ], "response#1": "MSSADVAATIVRLYESAVEAHPDKPVINDGHRVWSYRELNSAANRIAWWLIGRGVGPEQTVGVALDRGIDQIAALLGTLKAGAVYLPLDPVLPAERINYLLADATPSLILDGDAAASAGQPEDTPAVPLTSDSLAYVIYTSGSTGTPKGVGVTHGSMVNLARTVTGQYALGDTPRVLQLASLGFDVAIWELLTAVATGGTLVVSQADQLSGDDLLRVLREQRITHVTLPVPVLASLPPDAENQLPDLTTVHIGGETCPPELVRRWSAGRRLINGYGATETTVAATLTPPLTGPDAPIGKAIDGTRVYVLDDTLAQVVLGAAGELYVAGANVARGYLRRPGLTASRFLADPYGPPGSRMYRTGDVGLIRPDGQLEFLRRADDQVKIRGARVEPGELEAVLQRRTDVVHAAVTVRPDARGERQLVAYVVPAAAATGAAELRDDLRGTLPSYLVPSSVVLLDSLPLTPNGKVDRDALPDPEYAPAGLDRTARSPLEDMLRVVFAEILELPQVGFDDDFFDLGGHSLLAGRLIGRIRGTLGLEVHMKDFFEKSTPAALASYLQRQETGPARPELTRLPRPDRIPLSFAQQRLWFLHRLEGPSATYNMPLALHLTGKVDTGALAAALTDVIRRHEPLRTLIREVDGQPYQQILDPEEVRPALPVRQVGAAQLDEELRRSARHEFDLARQIPVRAELLTVSPDESVLMLVIHHIAGDGWSGAPLARDLVTAHSARLTGVAPQWPPLPVQYADYTLWQRAMLGGEEEPASPLNEQLRYWREQLADLPHEITVPGDRPRPAVATYRGGVVPITMDADLHAGITELARRNGATVYMVLQSTVTALLTRLGAGTDVAIGAGVAGRSEPALDDLVGLFVNMLVLRTDTAGSPRFTELLQQVRDTSLGAYGHQDIPFEQLVESLNPHRVAGRQSLFQVALVLQNNTSVPFDLPGLRVRAEQIPTGTARFDLSLSVTEHGDGISGTVEYAADLYDRATAEAVVERWIQLIRQVVADPARRVDTLDVTTPGDESRLAGWRRYERDVPPVTFGDLFARQVAATPDAIAVSDGGDVWTYREVNRYANHVADRLIDRGIGPEDFVAVAMPRSARLVASLLGVLKAGAAYVPVDLVFPARRNRHVIIDSNPRLVLTSRAGAENLPADLPCELVMIDAWGTGREDGPADADRVRPSNVDSPAYVIYTSGSTGQPKGVVVTHRGLAAFAETLRERCAAGPNDRVLQLSSPSVDASVLEMVWAFSSGARLVIASQYRLAGEELAQALAEQRITHAHIPPSALSTIPAEAAGRLPEFRRLSVGAESCPSELVRLWLPGRDFVNAYGPTECTVAASHTFPLAEARAPIGRPVIDAELYVLDETLRPAAPGVPGELYIGGAGLARGYLRRGGLTASRFVANPYGEPGSRVYRTGDVVRWNTDGELEYLGRSDEQVKVRGFRVEPGEVERVLASQPSVDRAVVVPRRDRSGAVSLAAYVVLAAASPAGFDDQLSEWNDIYDQVYAGFSGDAGNDFIGWTSSFTGGPIPIEEMREWQRSAVDAVRRFGRGRVLEIGSGSGLLMTPLADAVDEYWGTDLSEISIDRLRAFADARRWNHVRLSCQPAHDVSGLPRRYFDTVVINSVVQYFPSADYLRDVLAKVVDLLADGGRVIVGDVRHYGLLRVFHAAVHDFRGTEGLRAAVEHAMAVEKELLLAPEFFTSIDHPAVTGVEVTLKAGQASNELTGYRYEVVLHTAPARRLTTLPVLVWGRDTTDLDEVTGPARVTGIPNPRLAGGVAAVRLLDGMDAVPPAAGPELESEAVRRWAVQRGMRAVPTWSSNRWNTYDVVLIHAAEAEPLADVYRPADGVEPANVPEVARTAGKLVSELRSTVQGLLPDYMVPATITPIERIPVTPNGKIDRRALPDPEVVLSRGRHARTPLEQILCELYADILGLERVGVDDSFFDRGGHSLLATRLTSRIRSVLGVEALLQQVFAAPSPAELAVVLSEQQGRVQQALEPVARPEVLPLSFAQQRLWFLHKLEGPSATYNSPLALRLSGTLEVTALRAALGDVVGRHEALRTVFAETDGVPYQKVLDVADVDLSVREVAADELPGVLRDAARYEFDLAREIPVRAWLFAAGPGEWVLMLVLHHIAADGWSLGPLARDLATAYADRRMGRGPSWSPLPVQYADYTLWQRRLLGDEADPDSVFGRQLAYWRGQLAGLPQQVTLPTDRPRPQTASYAGDVTMFRLDAGLHADLLRLARTSGATLFMVLQAALVAVLTRLGAGDDVPLGSPIAGRSDDGLDDLVGFFVNTLVLRADTSGNPGFDELLERVRDTSLEAYAHQDVPFEFLVEKLNPHRSTAHSPLFQVLLAFQNNSDTSFHLPGLRAEREEIGTRVSRVDLTLNITEAFGVNGAPQGIRGAVEYATDLYDARTVESFAARFVRMLQAAVADPSRRINAVDLLSDEENATVLALSGRDAAVPESRVWPAVFEATAAAAPDATAVVEGQLSWTYAQLNANANRLARYLIDRGVGPEDVVGVLMPRSAMQIATVLAIGKAGAAFLPIDPAYPAERVEYLIADARPKMLLADTAHVGVAAGAIAIDEPAVATALREAPVTDPAGVAVRLEHPAYVIYTSGSTGRPKGTIVTHSGLAALAVSGCERAAVDRDSRVLQLTSPSFDVSVFEFLAAFHAGAVLVMPEPGRLAGEELAELLADAGVSHAFVPPSVLATLPDEAPGRLAGLRSLVVGGEACSADLVRRWSVGRRMTNLYGPTETTVAASISRPMSTGAHPIGAPLPGTRVYVLDANLRPVPPGARGELYISGIGVARGYLGRPVLTASRFVADPFGPAGARAYRTGDVVRWNADGELEYFGRSDHQLKIRGFRVEPGEIEAALVRRPSVAQAVVVARPDQHGFQALYAYVTAGAEPADAARLREELRAELPDYLVPAAIVVLDEFPLNANGKLDRNALPEPRFVTSAADIRSPGMPQEEILRSVFADVLGIERISADDNFFDLGGHSLLVTRLISRVRGTLGVDVSMQTFFNAPTPRQLAGQLLEGGPVPARLQPVPRPEALPLSFAQQRLWFLHKLEGPSATYNSPLAIKLSGELDVDALRLALADVVVRHEALRTVFAERAGNPYQRILDSAEVELPVREVPQSKLPDALREAARYEFDLAREIPLRAWLFTAGPGEWVLMLALHHVVADGWSLQVLVSNLTAAYTSRRAGHAPSWQPLPVQYADYTLWQRRHLGTEDDPDSVSSRQVSYWLEQLADLPDQVTLPTDRPRPAVASYRGETVTFDLDAEEHAELVRLARETGTTLFMILQAALAGLLTRLGAGTDIAIGSPIAGRTDDRLENLIGLFVNMLVLRTDTGGDPTLGELLTRVRETSLAAYAHQHMPFEYLVERLNPHRSAAHHPLVQILFGLQNTAEQNVSLPGVTASGMSVDTGVSRVDLSINIVEASAPDGSPAGLTGLVEFSTDLYDRATVEAFAARWVRVLRAMVVAPGSRLSGVQLLGADERVRLLQRWGAASGPVAAVTLAELFERRVAARPDAVAVVEGEVSWSYARLNAYANRVAWSLVERGVGVEDVVAVVLPRGAVQVATVLGVVKAGAAYLPVDPSYPRARVEYLLQDAGPALVIGESDVFDGQPEHDPVRPVPVDAAAYVIYTSGSTGQPKGVVVTHRGLASMAATQQRLGAGEGSRVLQFAALGFDATVWELVMALGAGAALVVPKTDQLAGEDLAAVLREQRITHLTLPPTVLATVPADRLPDLGTLVVAGEACPPELTARWSPGRRMFNAYGPTESTVCASISAELSPGLAPIGGPVLNTRLYVLDDALQPAASGVPGELYIAGEGLARGYRGRAGLTATRILADPYGPVGSRMYRTGDVVRWNADGDLEYLGRSDEQVKIRGFRVEPGEVASVLLRHPAVAQAAVIVRLEQLLAYAVPALGRAVRDGELRAYLQDELPEHTVPSAVVLLDEIPRTSHGKVDQRALPDPEQAGGRGRAPRTPQEELLCVLFAQVLDVQQVGPDDSFFDLGGHSLLATRLIIRIRRAFRCELPPRALFAAPSPAELAVVLSEQQGRVQQALEPVARPEVLPLSFAQQRLWFLHKLEGPSATYNSPLALRLSGTLEVTALRAALGDVVGRHEALRTVFAETDGVPYQKVLDVADVDLSVREVAADELPGVLRDAARYEFDLAREIPVRAWLFAAGPGEWVLMLVLHHIAADGWSLGPLARDLATAYADRRMGRGPSWSPLPVQYADYTLWQRRLLGDEADPDSVFGRQLAYWRGQLAGLPQQVTLPTDRPRPQTASYAGDVTMFRLDAGLHADLLRLARTSGATLFMVLQAALVAVLTRLGAGDDVPLGSPIAGRSDDGLDDLVGFFVNTLVLRADTSGNPGFDELLERVRDTSLEAYAHQDVPFEFLVEKLNPHRSTAHSPLFQVLLAFQNNSDTSFHLPGLRTRLEGVSTGLSRVDLFISLAEQPDAGGVIGAVEYATDLYDAATVEAFVGRWLRFLAAVAHDPEQRIGSVDLLLDGERERLTGWAYTEPEVEPATLSELFERRVAARPDAVAVVEGEVSWSYARLNAYANRVAWSLVERGVGVEDVVAVVLPRGAVQVATVLGVVKAGAAYLPVDPSYPRARVEYLLQDAGPALVIGESDVFDGQPEHDPVRPVPVDAAAYVIYTSGSTGQPKGVVVTHRGLAALATGTVGRNAVAGDSRVLLLASPSFDASVLELMIAIGAGAALVVSRESRLAGEELATLIAQARVTHAFVPPSVLATLPGAATGELPAFQGLVVGGEACSPDLVRRWSAGRRMTNLYGPTETTVATTVSRPLFGEAHPIGAPLPGWRVYVLDAGLHLVPPGSRGELYIGGVGLTRGYLRRAGLTASRFVADPFGPAGARMYRTGDVVRWNADGELEYLGRSDHQVQIRGIRVEPGEVQAALTAHPDVARAVVVVSDDRRGDPALVGYMVPERPGADPAAVREDLRRILPDHLVPVAIVVLPEIPLTPNGKLDRDALPDPEYETSRGREPRTPEEEILCGLFTEVLGLKQVGAEDDFFDLGGHSLLGTRLISGIRAKLGFEVRLLTLFEASTPAALARAMLEANAPARTALEPMPRPELLPLSFAQQRLWFLHKLEGPSPTYNMPLTLQLSGPLDVPALRAALTDVVGRHEALRTVFAEHDGQAYQRILDPVEIELPVHDAASDEALQAAARHRFDLAGEIPLRVSLYAAGPGEWVLMLVLHHIVADGWSLRPLARDLATAYAARTAGRAPDWAPPPVQYADYTLWHRELLGDDADPDSAFGRQLAFWRDRLADLPEQVTLPTDRPRPRVASYRGDVSTFQVDAELHAGLMALARQTGSTLFMVLQTALSALLTRSGAGTDVVVGAGVAGRTDERLDDLVGFFVNMVVLRTDTSDDPTFVELLQRVRASSLAAYAHQDIPFEYLVEKINPLRSASHQSLFQIAMVLQNNAEADFDLSGVRVWQEGRGTGTSRFDLSLSLTETTTADGRPTGVTGVVEFSTDLYDRATVEAFAARWVRVLRAMVVAPGSRLSGVQLLGADERVRLLQRWGAASGPVAAVTLAELFERRVAARPDAVAVVEGEVSWSYARLNAYANRVAWSLVERGVGVEDVVAVVLPRGAVQVATVLGVVKAGAAYLPVDPSYPRARVEYLLQDAGPALVIGESDVFDGQPEHDPVRPVPVDAAAYVIYTSGSTGQPKGVVVTHRGLSGLAATLRQRCAADVDSRILQASSPSFDAAVLELVWAWDSGAALVIASADRLAGDELARALADHRITHALIPPSVLSTLAADAPRTLTDFRTLIVGAEACPPELLRRWAPGRRMVNAYGPTEATVVASQTGELHEPPVSIGKPALGTRLYVLDERLGLAAPGVPGELYIAGAGVARGYRTRPSLTASRFLADPYGPAGTRMYRTGDLVRWNADGDLEYLGRSDEQVKIRGFRVEPGEVERVLAAQPSVARAVVVPRPDRSGAVSLAAYVVLADQGSATDFDDQLDEWRSIYHEVYSGLAREPGTDFAGWNSSFTGTPIPIEQMREWQRSAVEQVARFGPRRVLEIGAGSGLLMVPLIERTEEYWATDFSAAAVERLREYARERGWEHAHLRCQPAHDMWGLPRSHFDTIVLNSVVQYFPSTDYLRDVLGKALDLLADGGRLVVGDVRHHGLLRAMHTAVQEFRNPGSGSSAVDHAVAIEKELLLAPEFFTAFRHPRATGVEVLLKRGSADNELTAYRYEVVLHTGATRPVGDLPELVWGHDVTDLADVTAPARLTRIPNPRLVGINEPRLHPEQVRRWAAERSWRAVPTWSPRNWDGYDVVLLAADEDEALTDVYRPGTPEVVANVPAVARTAGEHVSELRGTIKSLLPDHMVPATITPIERIPLTPNGKIDRRALPEPEIVTTTTEERGPRDPYEEILCELYADLLGLPRVGVDESFFDLGGHSLLATRLTSRIRAVLGIEVPLQQVFAASTPAQLAAVLAQGSGRAGPALEPAPRPEVLPLSFAQQRLWFMQNLEGASATYNSPLAVRLSGALDVAAMRAALGDVLARHEVLRTVFGERRGEPYQRILDAVEIDLPVRAVAEGDLTQVLRDASRHEFDLSREIPVRASLFNTGRDEWVLLLVVHHVAVDGWSMRPLTRDLTTAYEQRAAGRVPDWAPLRVQYADFALWQHRMLGDEADPDSRLSRQLAYWRDQLAGLPRLVTLPADRPRPDEASHRGAMLTRNLDADLHQALRVLARRHGSTLFMALQAALGAQLSRSGAGTDIPVGAPIAGRADDALEDLVGFFINTLVLRIDTSGRPSFTRLLKQVRETSLAAYAHQDVPFDHLVEKLNPDRSPGQHPLFQVQLVLQNTPDAEFELAGLTARPQLDGVETGVSRVDLSVNAIETFDDHGLPAGLILVVEYATDLYDSATVDAFLDEFGQLLHEVADSPDQPIGGLELDNIAAPVPGTLPQLFETWAAATPSAIAVTDGAADMTYAELNSRANRMARALIDRGAGPEDLVAVLLPRSVRQVATILAIAKSGAAYLPIDPTYPADRVAYLCADALPKLIVTDAAGSARLGADQPVIDVDDPATVAQWESRPDTDPTDRDRTTALGLDHPAYVIYTSGSTGRPKGAVITQAGLAGAAEAWVQRWGFEPGSRVLQLSSPSFDASIMDFIVAFAAQGTLVLPEPGLIAGEALARVLTEKRITHLVTLPSVLASMPVDVAGRLTGLRGLLLGGEVLTPDLAARWSPGRRMINVYGQTETTVACTMTDPLAGERVTVGRPIPGTRVYVLDALLRVVPPGTDGELYVAGPAVGRGYLHRAGLTASRFVADPYGPPGSRMYRTGDLGRLNYAFELEYAGRTDEQVKIRGMRVEPGEVEAALAEHPAVARAAVAVRADRQGDLALFGYVIPVQAGADVSGIREDLRRSLPEHLVPAVMTAMTDFPLTPNGKVDRDALPAPQVTAPVGRGPRTPQEEILCGLFAELLGLGQIGVEDNFFDLGGHSLLANKLIARIAEVMGTEIPIRTFFAGPTVAQLAEQLGSDGTDRAFDVLLPLRTGGTLPPLFCIHPGAAICWSYADLLLHLSPDFPVYGLQSPALSHPDELPETLIQVADDCIEEMRQVQKTGPYYLLGQSFGGVVAHAMAARLEAAGEQVGLIVALDSEPSRSLSEHEQAQVIEATAKVYTGILEVLGVDPAALPSGNLTFAQFSELARTTNTLLGNVAEDEFHLLMAILHGNISIATRHRSERVDADMLIFGAAEERERVLDPEVWREFVGGEITYHPIPTSHSTIMAPEALQVIGPILEQHLRAVIAGNATTKEEN", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more PP-bd_ACP, AA_adenyl_dom, AA_adenyl_dom, AA_adenyl_dom, AA_adenyl_dom, AA_adenyl_dom, AA_adenyl_dom, AA_adenyl_dom, PP-bd_ACP, PKS_PP-bd, PKS_PP-bd, PKS_PP-bd, PKS_PP-bd, PKS_PP-bd, PKS_PP-bd, PKS_PP-bd, PP-bd_ACP, PP-bd_ACP, PP-bd_ACP, PP-bd_ACP, PP-bd_ACP, PP-bd_ACP, PP-bd_ACP, Condensatn, Condensatn, Condensatn, Condensatn, Condensatn, Condensatn, PP-bd_ACP, AMP-dep_synth/lig_dom, AMP-dep_synth/lig_dom, AMP-dep_synth/lig_dom, AMP-dep_synth/lig_dom, AMP-dep_synth/lig_dom, AMP-dep_synth/lig_dom, AMP-dep_synth/lig_dom, PP-bd_ACP, PP-bd_ACP, Thioesterase, PKS_thioesterase, PP-bd_ACP, PP-bd_ACP, AMP-bd_C, AMP-bd_C, AMP-bd_C, AMP-bd_C, AMP-bd_C, Methyltransf_12, Methyltransf_12 that are essential for its biological function; 2. The protein should be classified within ACP-like_sf, AB_hydrolase_fold, CAT-like_dom_sf, AMP-bd_C_sf, AMP-bd_C_sf, SAM-dependent_MTases_sf, ACP-like_sf, ACP-like_sf, ACP-like_sf, ACP-like_sf, AMP-bd_C_sf, AMP-bd_C_sf, AMP-bd_C_sf, AMP-bd_C_sf, CAT-like_dom_sf, ACP-like_sf, CAT-like_dom_sf, ACP-like_sf, CAT-like_dom_sf, AB_hydrolase_fold, CAT-like_dom_sf, SAM-dependent_MTases_sf, SAM-dependent_MTases_sf, CAT-like_dom_sf, AMP-bd_C_sf, AMP-bd_C_sf, ACP-like_sf, ANL_N_sf, ANL_N_sf, ANL_N_sf, ANL_N_sf, ANL_N_sf, ACP-like_sf, ACP-like_sf, ACP-like_sf, ACP-like_sf, SAM-dependent_MTases_sf, AMP-bd_C_sf, ACP-like_sf sharing conserved structural features; 3. The protein should contain AMP-binding_CS, AMP-binding_CS, AMP-binding_CS, AMP-binding_CS, AMP-binding_CS, AMP-binding_CS, AMP-binding_CS that is preserved across related proteins; 4. The protein should contain Ppantetheine_attach_site, Ppantetheine_attach_site, Ppantetheine_attach_site, Ppantetheine_attach_site that allow regulation through chemical modifications. The designed protein sequence is ", "reference": "MSSADVAATIVRLYESAVEAHPDKPVINDGHRVWSYRELNSAANRIAWWLIGRGVGPEQTVGVALDRGIDQIAALLGTLKAGAVYLPLDPVLPAERINYLLADATPSLILDGDAAASAGQPEDTPAVPLTSDSLAYVIYTSGSTGTPKGVGVTHGSMVNLARTVTGQYALGDTPRVLQLASLGFDVAIWELLTAVATGGTLVVSQADQLSGDDLLRVLREQRITHVTLPVPVLASLPPDAENQLPDLTTVHIGGETCPPELVRRWSAGRRLINGYGATETTVAATLTPPLTGPDAPIGKAIDGTRVYVLDDTLAQVVLGAAGELYVAGANVARGYLRRPGLTASRFLADPYGPPGSRMYRTGDVGLIRPDGQLEFLRRADDQVKIRGARVEPGELEAVLQRRTDVVHAAVTVRPDARGERQLVAYVVPAAAATGAAELRDDLRGTLPSYLVPSSVVLLDSLPLTPNGKVDRDALPDPEYAPAGLDRTARSPLEDMLRVVFAEILELPQVGFDDDFFDLGGHSLLAGRLIGRIRGTLGLEVHMKDFFEKSTPAALASYLQRQETGPARPELTRLPRPDRIPLSFAQQRLWFLHRLEGPSATYNMPLALHLTGKVDTGALAAALTDVIRRHEPLRTLIREVDGQPYQQILDPEEVRPALPVRQVGAAQLDEELRRSARHEFDLARQIPVRAELLTVSPDESVLMLVIHHIAGDGWSGAPLARDLVTAHSARLTGVAPQWPPLPVQYADYTLWQRAMLGGEEEPASPLNEQLRYWREQLADLPHEITVPGDRPRPAVATYRGGVVPITMDADLHAGITELARRNGATVYMVLQSTVTALLTRLGAGTDVAIGAGVAGRSEPALDDLVGLFVNMLVLRTDTAGSPRFTELLQQVRDTSLGAYGHQDIPFEQLVESLNPHRVAGRQSLFQVALVLQNNTSVPFDLPGLRVRAEQIPTGTARFDLSLSVTEHGDGISGTVEYAADLYDRATAEAVVERWIQLIRQVVADPARRVDTLDVTTPGDESRLAGWRRYERDVPPVTFGDLFARQVAATPDAIAVSDGGDVWTYREVNRYANHVADRLIDRGIGPEDFVAVAMPRSARLVASLLGVLKAGAAYVPVDLVFPARRNRHVIIDSNPRLVLTSRAGAENLPADLPCELVMIDAWGTGREDGPADADRVRPSNVDSPAYVIYTSGSTGQPKGVVVTHRGLAAFAETLRERCAAGPNDRVLQLSSPSVDASVLEMVWAFSSGARLVIASQYRLAGEELAQALAEQRITHAHIPPSALSTIPAEAAGRLPEFRRLSVGAESCPSELVRLWLPGRDFVNAYGPTECTVAASHTFPLAEARAPIGRPVIDAELYVLDETLRPAAPGVPGELYIGGAGLARGYLRRGGLTASRFVANPYGEPGSRVYRTGDVVRWNTDGELEYLGRSDEQVKVRGFRVEPGEVERVLASQPSVDRAVVVPRRDRSGAVSLAAYVVLAAASPAGFDDQLSEWNDIYDQVYAGFSGDAGNDFIGWTSSFTGGPIPIEEMREWQRSAVDAVRRFGRGRVLEIGSGSGLLMTPLADAVDEYWGTDLSEISIDRLRAFADARRWNHVRLSCQPAHDVSGLPRRYFDTVVINSVVQYFPSADYLRDVLAKVVDLLADGGRVIVGDVRHYGLLRVFHAAVHDFRGTEGLRAAVEHAMAVEKELLLAPEFFTSIDHPAVTGVEVTLKAGQASNELTGYRYEVVLHTAPARRLTTLPVLVWGRDTTDLDEVTGPARVTGIPNPRLAGGVAAVRLLDGMDAVPPAAGPELESEAVRRWAVQRGMRAVPTWSSNRWNTYDVVLIHAAEAEPLADVYRPADGVEPANVPEVARTAGKLVSELRSTVQGLLPDYMVPATITPIERIPVTPNGKIDRRALPDPEVVLSRGRHARTPLEQILCELYADILGLERVGVDDSFFDRGGHSLLATRLTSRIRSVLGVEALLQQVFAAPSPAELAVVLSEQQGRVQQALEPVARPEVLPLSFAQQRLWFLHKLEGPSATYNSPLALRLSGTLEVTALRAALGDVVGRHEALRTVFAETDGVPYQKVLDVADVDLSVREVAADELPGVLRDAARYEFDLAREIPVRAWLFAAGPGEWVLMLVLHHIAADGWSLGPLARDLATAYADRRMGRGPSWSPLPVQYADYTLWQRRLLGDEADPDSVFGRQLAYWRGQLAGLPQQVTLPTDRPRPQTASYAGDVTMFRLDAGLHADLLRLARTSGATLFMVLQAALVAVLTRLGAGDDVPLGSPIAGRSDDGLDDLVGFFVNTLVLRADTSGNPGFDELLERVRDTSLEAYAHQDVPFEFLVEKLNPHRSTAHSPLFQVLLAFQNNSDTSFHLPGLRAEREEIGTRVSRVDLTLNITEAFGVNGAPQGIRGAVEYATDLYDARTVESFAARFVRMLQAAVADPSRRINAVDLLSDEENATVLALSGRDAAVPESRVWPAVFEATAAAAPDATAVVEGQLSWTYAQLNANANRLARYLIDRGVGPEDVVGVLMPRSAMQIATVLAIGKAGAAFLPIDPAYPAERVEYLIADARPKMLLADTAHVGVAAGAIAIDEPAVATALREAPVTDPAGVAVRLEHPAYVIYTSGSTGRPKGTIVTHSGLAALAVSGCERAAVDRDSRVLQLTSPSFDVSVFEFLAAFHAGAVLVMPEPGRLAGEELAELLADAGVSHAFVPPSVLATLPDEAPGRLAGLRSLVVGGEACSADLVRRWSVGRRMTNLYGPTETTVAASISRPMSTGAHPIGAPLPGTRVYVLDANLRPVPPGARGELYISGIGVARGYLGRPVLTASRFVADPFGPAGARAYRTGDVVRWNADGELEYFGRSDHQLKIRGFRVEPGEIEAALVRRPSVAQAVVVARPDQHGFQALYAYVTAGAEPADAARLREELRAELPDYLVPAAIVVLDEFPLNANGKLDRNALPEPRFVTSAADIRSPGMPQEEILRSVFADVLGIERISADDNFFDLGGHSLLVTRLISRVRGTLGVDVSMQTFFNAPTPRQLAGQLLEGGPVPARLQPVPRPEALPLSFAQQRLWFLHKLEGPSATYNSPLAIKLSGELDVDALRLALADVVVRHEALRTVFAERAGNPYQRILDSAEVELPVREVPQSKLPDALREAARYEFDLAREIPLRAWLFTAGPGEWVLMLALHHVVADGWSLQVLVSNLTAAYTSRRAGHAPSWQPLPVQYADYTLWQRRHLGTEDDPDSVSSRQVSYWLEQLADLPDQVTLPTDRPRPAVASYRGETVTFDLDAEEHAELVRLARETGTTLFMILQAALAGLLTRLGAGTDIAIGSPIAGRTDDRLENLIGLFVNMLVLRTDTGGDPTLGELLTRVRETSLAAYAHQHMPFEYLVERLNPHRSAAHHPLVQILFGLQNTAEQNVSLPGVTASGMSVDTGVSRVDLSINIVEASAPDGSPAGLTGLVEFSTDLYDRATVEAFAARWVRVLRAMVVAPGSRLSGVQLLGADERVRLLQRWGAASGPVAAVTLAELFERRVAARPDAVAVVEGEVSWSYARLNAYANRVAWSLVERGVGVEDVVAVVLPRGAVQVATVLGVVKAGAAYLPVDPSYPRARVEYLLQDAGPALVIGESDVFDGQPEHDPVRPVPVDAAAYVIYTSGSTGQPKGVVVTHRGLASMAATQQRLGAGEGSRVLQFAALGFDATVWELVMALGAGAALVVPKTDQLAGEDLAAVLREQRITHLTLPPTVLATVPADRLPDLGTLVVAGEACPPELTARWSPGRRMFNAYGPTESTVCASISAELSPGLAPIGGPVLNTRLYVLDDALQPAASGVPGELYIAGEGLARGYRGRAGLTATRILADPYGPVGSRMYRTGDVVRWNADGDLEYLGRSDEQVKIRGFRVEPGEVASVLLRHPAVAQAAVIVRLEQLLAYAVPALGRAVRDGELRAYLQDELPEHTVPSAVVLLDEIPRTSHGKVDQRALPDPEQAGGRGRAPRTPQEELLCVLFAQVLDVQQVGPDDSFFDLGGHSLLATRLIIRIRRAFRCELPPRALFAAPSPAELAVVLSEQQGRVQQALEPVARPEVLPLSFAQQRLWFLHKLEGPSATYNSPLALRLSGTLEVTALRAALGDVVGRHEALRTVFAETDGVPYQKVLDVADVDLSVREVAADELPGVLRDAARYEFDLAREIPVRAWLFAAGPGEWVLMLVLHHIAADGWSLGPLARDLATAYADRRMGRGPSWSPLPVQYADYTLWQRRLLGDEADPDSVFGRQLAYWRGQLAGLPQQVTLPTDRPRPQTASYAGDVTMFRLDAGLHADLLRLARTSGATLFMVLQAALVAVLTRLGAGDDVPLGSPIAGRSDDGLDDLVGFFVNTLVLRADTSGNPGFDELLERVRDTSLEAYAHQDVPFEFLVEKLNPHRSTAHSPLFQVLLAFQNNSDTSFHLPGLRTRLEGVSTGLSRVDLFISLAEQPDAGGVIGAVEYATDLYDAATVEAFVGRWLRFLAAVAHDPEQRIGSVDLLLDGERERLTGWAYTEPEVEPATLSELFERRVAARPDAVAVVEGEVSWSYARLNAYANRVAWSLVERGVGVEDVVAVVLPRGAVQVATVLGVVKAGAAYLPVDPSYPRARVEYLLQDAGPALVIGESDVFDGQPEHDPVRPVPVDAAAYVIYTSGSTGQPKGVVVTHRGLAALATGTVGRNAVAGDSRVLLLASPSFDASVLELMIAIGAGAALVVSRESRLAGEELATLIAQARVTHAFVPPSVLATLPGAATGELPAFQGLVVGGEACSPDLVRRWSAGRRMTNLYGPTETTVATTVSRPLFGEAHPIGAPLPGWRVYVLDAGLHLVPPGSRGELYIGGVGLTRGYLRRAGLTASRFVADPFGPAGARMYRTGDVVRWNADGELEYLGRSDHQVQIRGIRVEPGEVQAALTAHPDVARAVVVVSDDRRGDPALVGYMVPERPGADPAAVREDLRRILPDHLVPVAIVVLPEIPLTPNGKLDRDALPDPEYETSRGREPRTPEEEILCGLFTEVLGLKQVGAEDDFFDLGGHSLLGTRLISGIRAKLGFEVRLLTLFEASTPAALARAMLEANAPARTALEPMPRPELLPLSFAQQRLWFLHKLEGPSPTYNMPLTLQLSGPLDVPALRAALTDVVGRHEALRTVFAEHDGQAYQRILDPVEIELPVHDAASDEALQAAARHRFDLAGEIPLRVSLYAAGPGEWVLMLVLHHIVADGWSLRPLARDLATAYAARTAGRAPDWAPPPVQYADYTLWHRELLGDDADPDSAFGRQLAFWRDRLADLPEQVTLPTDRPRPRVASYRGDVSTFQVDAELHAGLMALARQTGSTLFMVLQTALSALLTRSGAGTDVVVGAGVAGRTDERLDDLVGFFVNMVVLRTDTSDDPTFVELLQRVRASSLAAYAHQDIPFEYLVEKINPLRSASHQSLFQIAMVLQNNAEADFDLSGVRVWQEGRGTGTSRFDLSLSLTETTTADGRPTGVTGVVEFSTDLYDRATVEAFAARWVRVLRAMVVAPGSRLSGVQLLGADERVRLLQRWGAASGPVAAVTLAELFERRVAARPDAVAVVEGEVSWSYARLNAYANRVAWSLVERGVGVEDVVAVVLPRGAVQVATVLGVVKAGAAYLPVDPSYPRARVEYLLQDAGPALVIGESDVFDGQPEHDPVRPVPVDAAAYVIYTSGSTGQPKGVVVTHRGLSGLAATLRQRCAADVDSRILQASSPSFDAAVLELVWAWDSGAALVIASADRLAGDELARALADHRITHALIPPSVLSTLAADAPRTLTDFRTLIVGAEACPPELLRRWAPGRRMVNAYGPTEATVVASQTGELHEPPVSIGKPALGTRLYVLDERLGLAAPGVPGELYIAGAGVARGYRTRPSLTASRFLADPYGPAGTRMYRTGDLVRWNADGDLEYLGRSDEQVKIRGFRVEPGEVERVLAAQPSVARAVVVPRPDRSGAVSLAAYVVLADQGSATDFDDQLDEWRSIYHEVYSGLAREPGTDFAGWNSSFTGTPIPIEQMREWQRSAVEQVARFGPRRVLEIGAGSGLLMVPLIERTEEYWATDFSAAAVERLREYARERGWEHAHLRCQPAHDMWGLPRSHFDTIVLNSVVQYFPSTDYLRDVLGKALDLLADGGRLVVGDVRHHGLLRAMHTAVQEFRNPGSGSSAVDHAVAIEKELLLAPEFFTAFRHPRATGVEVLLKRGSADNELTAYRYEVVLHTGATRPVGDLPELVWGHDVTDLADVTAPARLTRIPNPRLVGINEPRLHPEQVRRWAAERSWRAVPTWSPRNWDGYDVVLLAADEDEALTDVYRPGTPEVVANVPAVARTAGEHVSELRGTIKSLLPDHMVPATITPIERIPLTPNGKIDRRALPEPEIVTTTTEERGPRDPYEEILCELYADLLGLPRVGVDESFFDLGGHSLLATRLTSRIRAVLGIEVPLQQVFAASTPAQLAAVLAQGSGRAGPALEPAPRPEVLPLSFAQQRLWFMQNLEGASATYNSPLAVRLSGALDVAAMRAALGDVLARHEVLRTVFGERRGEPYQRILDAVEIDLPVRAVAEGDLTQVLRDASRHEFDLSREIPVRASLFNTGRDEWVLLLVVHHVAVDGWSMRPLTRDLTTAYEQRAAGRVPDWAPLRVQYADFALWQHRMLGDEADPDSRLSRQLAYWRDQLAGLPRLVTLPADRPRPDEASHRGAMLTRNLDADLHQALRVLARRHGSTLFMALQAALGAQLSRSGAGTDIPVGAPIAGRADDALEDLVGFFINTLVLRIDTSGRPSFTRLLKQVRETSLAAYAHQDVPFDHLVEKLNPDRSPGQHPLFQVQLVLQNTPDAEFELAGLTARPQLDGVETGVSRVDLSVNAIETFDDHGLPAGLILVVEYATDLYDSATVDAFLDEFGQLLHEVADSPDQPIGGLELDNIAAPVPGTLPQLFETWAAATPSAIAVTDGAADMTYAELNSRANRMARALIDRGAGPEDLVAVLLPRSVRQVATILAIAKSGAAYLPIDPTYPADRVAYLCADALPKLIVTDAAGSARLGADQPVIDVDDPATVAQWESRPDTDPTDRDRTTALGLDHPAYVIYTSGSTGRPKGAVITQAGLAGAAEAWVQRWGFEPGSRVLQLSSPSFDASIMDFIVAFAAQGTLVLPEPGLIAGEALARVLTEKRITHLVTLPSVLASMPVDVAGRLTGLRGLLLGGEVLTPDLAARWSPGRRMINVYGQTETTVACTMTDPLAGERVTVGRPIPGTRVYVLDALLRVVPPGTDGELYVAGPAVGRGYLHRAGLTASRFVADPYGPPGSRMYRTGDLGRLNYAFELEYAGRTDEQVKIRGMRVEPGEVEAALAEHPAVARAAVAVRADRQGDLALFGYVIPVQAGADVSGIREDLRRSLPEHLVPAVMTAMTDFPLTPNGKVDRDALPAPQVTAPVGRGPRTPQEEILCGLFAELLGLGQIGVEDNFFDLGGHSLLANKLIARIAEVMGTEIPIRTFFAGPTVAQLAEQLGSDGTDRAFDVLLPLRTGGTLPPLFCIHPGAAICWSYADLLLHLSPDFPVYGLQSPALSHPDELPETLIQVADDCIEEMRQVQKTGPYYLLGQSFGGVVAHAMAARLEAAGEQVGLIVALDSEPSRSLSEHEQAQVIEATAKVYTGILEVLGVDPAALPSGNLTFAQFSELARTTNTLLGNVAEDEFHLLMAILHGNISIATRHRSERVDADMLIFGAAEERERVLDPEVWREFVGGEITYHPIPTSHSTIMAPEALQVIGPILEQHLRAVIAGNATTKEEN" }, { "InterPro": [ { "InterPro-ID": "IPR049534", "InterPro-Name": "TEX13A/C/D_Znf", "InterPro-Type": "DOMAIN", "Beg": 349, "End": 368 }, { "InterPro-ID": "IPR001876", "InterPro-Name": "Znf_RanBP2", "InterPro-Type": "DOMAIN", "Beg": 349, "End": 368 }, { "InterPro-ID": "IPR001876", "InterPro-Name": "Znf_RanBP2", "InterPro-Type": "DOMAIN", "Beg": 345, "End": 369 }, { "InterPro-ID": "IPR028193", "InterPro-Name": "TEX13A-D_N", "InterPro-Type": "DOMAIN", "Beg": 5, "End": 154 }, { "InterPro-ID": "IPR036443", "InterPro-Name": "Znf_RanBP2_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 341, "End": 370 } ], "response#1": "MALNPEDLGSGFRHSKVSMFINEQMAKHDKGPDFYLENLSLSWEEVEDKFKVILEDSEVSNEAREACAWGTLALGVRFAHRQGCLQGHGVQWLQDLSSLHKMSALSLSPDLKQLIHQQEMAQKEVALQLQMAQAKLEEVQRERDLLRLKILQAELRALPNAVRPAVAIPPAVVRRGGIRTQWSSTKENLAEWMAAATGRPNERANMSDTALSGTITSPEEVLEDPNGSFMKLLGVMKCKNYPLKRQRLDLRPKKASMCSFSQSLNLRSTVSSEPFIVQLPASFTYSYESPFPAIPTTSQLPTTERQPHVYPYSMASDISHLSDMRIHRGDHQELPKDKRFSAFRRPGDWDCPWCKAVNFSRRENCFHCGKGIWLQNP", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more TEX13A/C/D_Znf, Znf_RanBP2, Znf_RanBP2, TEX13A-D_N that are essential for its biological function; 2. The protein should be classified within Znf_RanBP2_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MALNPEDLGSGFRHSKVSMFINEQMAKHDKGPDFYLENLSLSWEEVEDKFKVILEDSEVSNEAREACAWGTLALGVRFAHRQGCLQGHGVQWLQDLSSLHKMSALSLSPDLKQLIHQQEMAQKEVALQLQMAQAKLEEVQRERDLLRLKILQAELRALPNAVRPAVAIPPAVVRRGGIRTQWSSTKENLAEWMAAATGRPNERANMSDTALSGTITSPEEVLEDPNGSFMKLLGVMKCKNYPLKRQRLDLRPKKASMCSFSQSLNLRSTVSSEPFIVQLPASFTYSYESPFPAIPTTSQLPTTERQPHVYPYSMASDISHLSDMRIHRGDHQELPKDKRFSAFRRPGDWDCPWCKAVNFSRRENCFHCGKGIWLQNP" }, { "InterPro": [ { "InterPro-ID": "IPR036396", "InterPro-Name": "Cyt_P450_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 8, "End": 471 }, { "InterPro-ID": "IPR002403", "InterPro-Name": "Cyt_P450_E_grp-IV", "InterPro-Type": "FAMILY", "Beg": 427, "End": 445 }, { "InterPro-ID": "IPR002403", "InterPro-Name": "Cyt_P450_E_grp-IV", "InterPro-Type": "FAMILY", "Beg": 327, "End": 343 }, { "InterPro-ID": "IPR002403", "InterPro-Name": "Cyt_P450_E_grp-IV", "InterPro-Type": "FAMILY", "Beg": 364, "End": 378 }, { "InterPro-ID": "IPR002403", "InterPro-Name": "Cyt_P450_E_grp-IV", "InterPro-Type": "FAMILY", "Beg": 380, "End": 398 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 299, "End": 456 }, { "InterPro-ID": "IPR036396", "InterPro-Name": "Cyt_P450_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 8, "End": 456 } ], "response#1": "MSASGKEKPLKDVPGSYGVPVVGALKDRLDFYWFQGEVEFYKSRMEKNQSTVFRVNFPPGPPGFPEGHGIVLLDQVSYSVLLDNAKVDKRDTLIGSYMPDLAFTGGYRTLPYLDTAEEKHTTYKSLMFEILHESAQRFGPELSSAFDRTAQEWEAKIAKDGSVESLSTAGNMVIQFLYKTITHQDPMATMGDDPHSVYMAWTGVQFAGIAYTNLPHITEELLMHSFQLPFFPIKKKYEQIVEFFRSAGSGLLDLAVTKYGLDREEALHNLVFSFGINTRLGLLKMFPPILFFIARAGAEFQARLKQEIRGRMKKREDAASIQALGDLKLVKATVLEVFRLMPSIFVAFGRARQDLEVESHDARYKIKKGELLGTHQYFVMRDPVVFKDPHSFVPDRFMGSEGAALLPHIVWSNGRETDSPTPTNKQCPGKNQAELIAVQFIAEMFLRYDSWEVTQESSVSATKLDVHLCKLVKRS", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Cyt_P450_E_grp-IV, Cyt_P450_E_grp-IV, Cyt_P450_E_grp-IV, Cyt_P450_E_grp-IV, Cyt_P450 that shares evolutionary origin and functional similarity; 2. The protein should be classified within Cyt_P450_sf, Cyt_P450_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MSASGKEKPLKDVPGSYGVPVVGALKDRLDFYWFQGEVEFYKSRMEKNQSTVFRVNFPPGPPGFPEGHGIVLLDQVSYSVLLDNAKVDKRDTLIGSYMPDLAFTGGYRTLPYLDTAEEKHTTYKSLMFEILHESAQRFGPELSSAFDRTAQEWEAKIAKDGSVESLSTAGNMVIQFLYKTITHQDPMATMGDDPHSVYMAWTGVQFAGIAYTNLPHITEELLMHSFQLPFFPIKKKYEQIVEFFRSAGSGLLDLAVTKYGLDREEALHNLVFSFGINTRLGLLKMFPPILFFIARAGAEFQARLKQEIRGRMKKREDAASIQALGDLKLVKATVLEVFRLMPSIFVAFGRARQDLEVESHDARYKIKKGELLGTHQYFVMRDPVVFKDPHSFVPDRFMGSEGAALLPHIVWSNGRETDSPTPTNKQCPGKNQAELIAVQFIAEMFLRYDSWEVTQESSVSATKLDVHLCKLVKRS" }, { "InterPro": [ { "InterPro-ID": "IPR029044", "InterPro-Name": "Nucleotide-diphossugar_trans", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 189, "End": 362 }, { "InterPro-ID": "IPR029044", "InterPro-Name": "Nucleotide-diphossugar_trans", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 76, "End": 167 }, { "InterPro-ID": "IPR005150", "InterPro-Name": "Cellulose_synth", "InterPro-Type": "FAMILY", "Beg": 371, "End": 692 }, { "InterPro-ID": "IPR005150", "InterPro-Name": "Cellulose_synth", "InterPro-Type": "FAMILY", "Beg": 88, "End": 362 }, { "InterPro-ID": "IPR029044", "InterPro-Name": "Nucleotide-diphossugar_trans", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 90, "End": 451 } ], "response#1": "MSPHNTCTLQITRALLSRLHILFHSALVASVFYYRFSNFSSGPAWALMTFAELTLAFIWALTQAFRWRPVVRAVFGPEEIDPAQLPGLDVFICTADPRKEPVMEVMNSVVSALALDYPAEKLAVYLSDDGGSPLTREVIREAAVFGKYWVGFCGKYNVKTRCPEAYFSSFCDGERVDHNQDYLNDELSVKSKFEAFKKYVQKASEDATKCIVVNDRPSCVEIIHDSKQNGEGEVKMPLLVYVAREKRPGFNHHAKAGAINTLLRVSGLLSNSPFFLVLDCDMYCNDPTSARQAMCFHLDPKLAPSLAFVQYPQIFYNTSKNDIYDGQARAAFKTKYQGMDGLRGPVMSGTGYFLKRKALYGKPHDQDELLREQPTKAFGSSKIFIASLGENTCVALKGLSKDELLQETQKLAACTYESNTLWGSEVGYSYDCLLESTYCGYLLHCKGWISVYLYPKKPCFLGCATVDMNDAMLQIMKWTSGLIGVGISKFSPFTYAMSRISIMQSLCYAYFAFSGLFAVFFLIYGVVLPYSLLQGVPLFPKAGDPWLLAFAGVFISSLLQHLYEVLSSGETVKAWWNEQRIWIIKSITACLFGLLDAMLNKIGVLKASFRLTNKAVDKQKLDKYEKGRFDFQGAQMFMVPLMILVVFNLVSFFGGLRRTVIHKNYEDMFAQLFLSLFILALSYPIMEEIVRKARKGRS", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Cellulose_synth, Cellulose_synth that shares evolutionary origin and functional similarity; 2. The protein should be classified within Nucleotide-diphossugar_trans, Nucleotide-diphossugar_trans, Nucleotide-diphossugar_trans sharing conserved structural features. The designed protein sequence is ", "reference": "MSPHNTCTLQITRALLSRLHILFHSALVASVFYYRFSNFSSGPAWALMTFAELTLAFIWALTQAFRWRPVVRAVFGPEEIDPAQLPGLDVFICTADPRKEPVMEVMNSVVSALALDYPAEKLAVYLSDDGGSPLTREVIREAAVFGKYWVGFCGKYNVKTRCPEAYFSSFCDGERVDHNQDYLNDELSVKSKFEAFKKYVQKASEDATKCIVVNDRPSCVEIIHDSKQNGEGEVKMPLLVYVAREKRPGFNHHAKAGAINTLLRVSGLLSNSPFFLVLDCDMYCNDPTSARQAMCFHLDPKLAPSLAFVQYPQIFYNTSKNDIYDGQARAAFKTKYQGMDGLRGPVMSGTGYFLKRKALYGKPHDQDELLREQPTKAFGSSKIFIASLGENTCVALKGLSKDELLQETQKLAACTYESNTLWGSEVGYSYDCLLESTYCGYLLHCKGWISVYLYPKKPCFLGCATVDMNDAMLQIMKWTSGLIGVGISKFSPFTYAMSRISIMQSLCYAYFAFSGLFAVFFLIYGVVLPYSLLQGVPLFPKAGDPWLLAFAGVFISSLLQHLYEVLSSGETVKAWWNEQRIWIIKSITACLFGLLDAMLNKIGVLKASFRLTNKAVDKQKLDKYEKGRFDFQGAQMFMVPLMILVVFNLVSFFGGLRRTVIHKNYEDMFAQLFLSLFILALSYPIMEEIVRKARKGRS" }, { "InterPro": [ { "InterPro-ID": "IPR001360", "InterPro-Name": "Glyco_hydro_1", "InterPro-Type": "FAMILY", "Beg": 7, "End": 434 }, { "InterPro-ID": "IPR001360", "InterPro-Name": "Glyco_hydro_1", "InterPro-Type": "FAMILY", "Beg": 283, "End": 297 }, { "InterPro-ID": "IPR001360", "InterPro-Name": "Glyco_hydro_1", "InterPro-Type": "FAMILY", "Beg": 346, "End": 354 }, { "InterPro-ID": "IPR001360", "InterPro-Name": "Glyco_hydro_1", "InterPro-Type": "FAMILY", "Beg": 384, "End": 401 }, { "InterPro-ID": "IPR001360", "InterPro-Name": "Glyco_hydro_1", "InterPro-Type": "FAMILY", "Beg": 363, "End": 374 }, { "InterPro-ID": "IPR001360", "InterPro-Name": "Glyco_hydro_1", "InterPro-Type": "FAMILY", "Beg": 8, "End": 435 }, { "InterPro-ID": "IPR017853", "InterPro-Name": "Glycoside_hydrolase_SF", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 3, "End": 434 } ], "response#1": "MVLSRLDFPSDFIFGSGTSASQVEGAALEDGKTSTAFEGFLTRMSGNDLSKGVEGYYKYKEDVQLMVQTGLDAYRFSISWSRLIPGGKGPVNPKGLQYYNNFIDELIKNGIQPHVTLLHFDIPDTLMTAYNGLKGQEFVEDFTAFADVCFKEFGDRVLYWTTVNEANNFASLTLDEGNFMPSTEPYIRGHNIILAHASAVKLYREKYKKTQNGFIGLNLYASWYFPETDDEQDSIAAQRAIDFTIGWIMQPLIYGEYPETLKKQVGERLPTFTKEESTFVKNSFDFIGVNCYVGTAVKDDPDSCNSKNKTIITDMSAKLSPKGELGGAYMKGLLEYFKRDYGNPPIYIQENGYWTPRELGVNDASRIEYHTASLASMHDAMKNGANVKGYFQWSFLDLLEVFKYSYGLYHVDLEDPTRERRPKASANWYAEFLKGCATSNGNAKVETPL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Glyco_hydro_1, Glyco_hydro_1, Glyco_hydro_1, Glyco_hydro_1, Glyco_hydro_1, Glyco_hydro_1 that shares evolutionary origin and functional similarity; 2. The protein should be classified within Glycoside_hydrolase_SF sharing conserved structural features. The designed protein sequence is ", "reference": "MVLSRLDFPSDFIFGSGTSASQVEGAALEDGKTSTAFEGFLTRMSGNDLSKGVEGYYKYKEDVQLMVQTGLDAYRFSISWSRLIPGGKGPVNPKGLQYYNNFIDELIKNGIQPHVTLLHFDIPDTLMTAYNGLKGQEFVEDFTAFADVCFKEFGDRVLYWTTVNEANNFASLTLDEGNFMPSTEPYIRGHNIILAHASAVKLYREKYKKTQNGFIGLNLYASWYFPETDDEQDSIAAQRAIDFTIGWIMQPLIYGEYPETLKKQVGERLPTFTKEESTFVKNSFDFIGVNCYVGTAVKDDPDSCNSKNKTIITDMSAKLSPKGELGGAYMKGLLEYFKRDYGNPPIYIQENGYWTPRELGVNDASRIEYHTASLASMHDAMKNGANVKGYFQWSFLDLLEVFKYSYGLYHVDLEDPTRERRPKASANWYAEFLKGCATSNGNAKVETPL" }, { "InterPro": [ { "InterPro-ID": "IPR002213", "InterPro-Name": "UDP_glucos_trans", "InterPro-Type": "FAMILY", "Beg": 9, "End": 474 }, { "InterPro-ID": "IPR002213", "InterPro-Name": "UDP_glucos_trans", "InterPro-Type": "FAMILY", "Beg": 273, "End": 398 } ], "response#1": "MKSPLKLYFLPYISPGHMIPLSEMARLFANQGHHVTIITTTSNATLLQKYTTATLSLHLIPLPTKEAGLPDGLENFISVNDLETAGKLYYALSLLQPVIEEFITSNPPDCIVSDMFYPWTADLASQLQVPRMVFHAACIFAMCMKESMRGPDAPHLKVSSDYELFEVKGLPDPVFMTRAQLPDYVRTPNGYTQLMEMWREAEKKSYGVMVNNFYELDPAYTEHYSKIMGHKVWNIGPAAQILHRGSGDKIERVHKAVVGENQCLSWLDTKEPNSVFYVCFGSAIRFPDDQLYEIASALESSGAQFIWAVLGKDSDNSDSNSDSEWLPAGFEEKMKETGRGMIIRGWAPQVLILDHPSVGGFMTHCGWNSTIEGVSAGVGMVTWPLYAEQFYNEKLITQVLKIGVEAGVEEWNLWVDVGRKLVKREKIEAAIRAVMGEAGVEMRRKAKELSVKAKKAVQDGGSSHRNLMALIEDLQRIRDDKMSKVAN", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to UDP_glucos_trans, UDP_glucos_trans that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MKSPLKLYFLPYISPGHMIPLSEMARLFANQGHHVTIITTTSNATLLQKYTTATLSLHLIPLPTKEAGLPDGLENFISVNDLETAGKLYYALSLLQPVIEEFITSNPPDCIVSDMFYPWTADLASQLQVPRMVFHAACIFAMCMKESMRGPDAPHLKVSSDYELFEVKGLPDPVFMTRAQLPDYVRTPNGYTQLMEMWREAEKKSYGVMVNNFYELDPAYTEHYSKIMGHKVWNIGPAAQILHRGSGDKIERVHKAVVGENQCLSWLDTKEPNSVFYVCFGSAIRFPDDQLYEIASALESSGAQFIWAVLGKDSDNSDSNSDSEWLPAGFEEKMKETGRGMIIRGWAPQVLILDHPSVGGFMTHCGWNSTIEGVSAGVGMVTWPLYAEQFYNEKLITQVLKIGVEAGVEEWNLWVDVGRKLVKREKIEAAIRAVMGEAGVEMRRKAKELSVKAKKAVQDGGSSHRNLMALIEDLQRIRDDKMSKVAN" }, { "InterPro": [ { "InterPro-ID": "IPR036291", "InterPro-Name": "NAD(P)-bd_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 12, "End": 283 }, { "InterPro-ID": "IPR002347", "InterPro-Name": "SDR_fam", "InterPro-Type": "FAMILY", "Beg": 226, "End": 245 }, { "InterPro-ID": "IPR002347", "InterPro-Name": "SDR_fam", "InterPro-Type": "FAMILY", "Beg": 90, "End": 101 }, { "InterPro-ID": "IPR002347", "InterPro-Name": "SDR_fam", "InterPro-Type": "FAMILY", "Beg": 163, "End": 171 }, { "InterPro-ID": "IPR002347", "InterPro-Name": "SDR_fam", "InterPro-Type": "FAMILY", "Beg": 13, "End": 175 }, { "InterPro-ID": "IPR002347", "InterPro-Name": "SDR_fam", "InterPro-Type": "FAMILY", "Beg": 13, "End": 30 }, { "InterPro-ID": "IPR002347", "InterPro-Name": "SDR_fam", "InterPro-Type": "FAMILY", "Beg": 245, "End": 262 }, { "InterPro-ID": "IPR002347", "InterPro-Name": "SDR_fam", "InterPro-Type": "FAMILY", "Beg": 157, "End": 173 }, { "InterPro-ID": "IPR020904", "InterPro-Name": "Sc_DH/Rdtase_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 213, "End": 241 }, { "InterPro-ID": "IPR045313", "InterPro-Name": "CBR1-like", "InterPro-Type": "FAMILY", "Beg": 12, "End": 301 }, { "InterPro-ID": "IPR002347", "InterPro-Name": "SDR_fam", "InterPro-Type": "FAMILY", "Beg": 215, "End": 265 } ], "response#1": "MAEASSFLAQKRYAVVTGANKGLGLEICGQLASQGVTVLLTSRDEKRGLEAIEELKKSGINSENLEYHQLDVTKPASFASLADFIKAKFGKLDILVNNAGISGVIVDYAALMEAIRRRGAEINYDGVMKQTYELAEECLQTNYYGVKRTINALLPLLQFSDSPRIVNVSSDVGLLKKIPGERIREALGDVEKLTEESVDGILDEFLRDFKEGKIAEKGWPTFKSAYSISKAALNSYTRVLARKYPSIIINCVCPGVVKTDINLKMGHLTVEEGAASPVRLALMPLGSPSGLFYTRNEVTPFE", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to SDR_fam, SDR_fam, SDR_fam, SDR_fam, SDR_fam, SDR_fam, SDR_fam, CBR1-like, SDR_fam that shares evolutionary origin and functional similarity; 2. The protein should be classified within NAD(P)-bd_dom_sf sharing conserved structural features; 3. The protein should contain Sc_DH/Rdtase_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MAEASSFLAQKRYAVVTGANKGLGLEICGQLASQGVTVLLTSRDEKRGLEAIEELKKSGINSENLEYHQLDVTKPASFASLADFIKAKFGKLDILVNNAGISGVIVDYAALMEAIRRRGAEINYDGVMKQTYELAEECLQTNYYGVKRTINALLPLLQFSDSPRIVNVSSDVGLLKKIPGERIREALGDVEKLTEESVDGILDEFLRDFKEGKIAEKGWPTFKSAYSISKAALNSYTRVLARKYPSIIINCVCPGVVKTDINLKMGHLTVEEGAASPVRLALMPLGSPSGLFYTRNEVTPFE" }, { "InterPro": [ { "InterPro-ID": "IPR002213", "InterPro-Name": "UDP_glucos_trans", "InterPro-Type": "FAMILY", "Beg": 320, "End": 408 }, { "InterPro-ID": "IPR002213", "InterPro-Name": "UDP_glucos_trans", "InterPro-Type": "FAMILY", "Beg": 6, "End": 408 }, { "InterPro-ID": "IPR050481", "InterPro-Name": "UDP-glycosyltransf_plant", "InterPro-Type": "FAMILY", "Beg": 6, "End": 441 } ], "response#1": "MSAKMLHVVMYPWFAYGHMIPFLHLSNKLAETGHKVTYILPPKALTRLQNLNLNPTQITFRTITVPRVDGLPAGAENVTDIPDITLHTHLATALDRTRPEFETIVELIKPDVIMYDVAYWVPEVAVKYGAKSVAYSVVSAASVSLSKTVVDRMTPLEKPMTEEERKKKFAQYPHLIQLYGPFGEGITMYDRLTGMLSKCDAIACRTCREIEGKYCQYLSTQYEKKVTLTGPVLPEPEVGATLEAPWSEWLSRFKLGSVLFCAFGSQFYLDKDQFQEIILGLEMTNLPFLMAVQPPKGCATIEEAYPEGFAERVKDRGVVTSQWVQQLVILAHPAVGCFVNHCAFGTMWEALLSEKQLVMIPQLGDQILNTKMLADELKVGVEVERGIGGWVSKENLCKAIKSVMDEDSEIGKDVKQSHEKWRATLSSKDLMSTYIDSFIKDLQALVE", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to UDP_glucos_trans, UDP_glucos_trans, UDP-glycosyltransf_plant that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MSAKMLHVVMYPWFAYGHMIPFLHLSNKLAETGHKVTYILPPKALTRLQNLNLNPTQITFRTITVPRVDGLPAGAENVTDIPDITLHTHLATALDRTRPEFETIVELIKPDVIMYDVAYWVPEVAVKYGAKSVAYSVVSAASVSLSKTVVDRMTPLEKPMTEEERKKKFAQYPHLIQLYGPFGEGITMYDRLTGMLSKCDAIACRTCREIEGKYCQYLSTQYEKKVTLTGPVLPEPEVGATLEAPWSEWLSRFKLGSVLFCAFGSQFYLDKDQFQEIILGLEMTNLPFLMAVQPPKGCATIEEAYPEGFAERVKDRGVVTSQWVQQLVILAHPAVGCFVNHCAFGTMWEALLSEKQLVMIPQLGDQILNTKMLADELKVGVEVERGIGGWVSKENLCKAIKSVMDEDSEIGKDVKQSHEKWRATLSSKDLMSTYIDSFIKDLQALVE" }, { "InterPro": [ { "InterPro-ID": "IPR035595", "InterPro-Name": "UDP_glycos_trans_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 353, "End": 396 }, { "InterPro-ID": "IPR002213", "InterPro-Name": "UDP_glucos_trans", "InterPro-Type": "FAMILY", "Beg": 9, "End": 480 }, { "InterPro-ID": "IPR002213", "InterPro-Name": "UDP_glucos_trans", "InterPro-Type": "FAMILY", "Beg": 280, "End": 416 } ], "response#1": "MEESKEEVHVAFFPFMTPGHSIPMLDLVRLFIARGVKTTVFTTPLNAPNISKYLNIIQDSSSNKNTIYVTPFPSKEAGLPEGVESQDSTTSPEMTLKFFVAMELLQDPLDVFLKETKPHCLVADNFFPYATDIASKYGIPRFVFQFTGFFPMSVMMALNRFHPQNSVSSDDDPFLVPSLPHDIKLTKSQLQREYEGSDGIDTALSRLCNGAGRALFTSYGVIFNSFYQLEPDYVDYYTNTMGKRSRVWHVGPVSLCNRRHVEGKSGRGRSASISEHLCLEWLNAKEPNSVIYVCFGSLTCFSNEQLKEIATALERCEEYFIWVLKGGKDNEQEWLPQGFEERVEGKGLIIRGWAPQVLILDHEAIGGFVTHCGWNSTLESISAGVPMVTWPIYAEQFYNEKLVTDVLKVGVKVGSMKWSETTGATHLKHEEIEKALKQIMVGEEVLEMRKRASKLKEMAYNAVEEGGSSYSHLTSLIDDLMASKAVLQKF", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to UDP_glucos_trans, UDP_glucos_trans that shares evolutionary origin and functional similarity; 2. The protein should contain UDP_glycos_trans_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MEESKEEVHVAFFPFMTPGHSIPMLDLVRLFIARGVKTTVFTTPLNAPNISKYLNIIQDSSSNKNTIYVTPFPSKEAGLPEGVESQDSTTSPEMTLKFFVAMELLQDPLDVFLKETKPHCLVADNFFPYATDIASKYGIPRFVFQFTGFFPMSVMMALNRFHPQNSVSSDDDPFLVPSLPHDIKLTKSQLQREYEGSDGIDTALSRLCNGAGRALFTSYGVIFNSFYQLEPDYVDYYTNTMGKRSRVWHVGPVSLCNRRHVEGKSGRGRSASISEHLCLEWLNAKEPNSVIYVCFGSLTCFSNEQLKEIATALERCEEYFIWVLKGGKDNEQEWLPQGFEERVEGKGLIIRGWAPQVLILDHEAIGGFVTHCGWNSTLESISAGVPMVTWPIYAEQFYNEKLVTDVLKVGVKVGSMKWSETTGATHLKHEEIEKALKQIMVGEEVLEMRKRASKLKEMAYNAVEEGGSSYSHLTSLIDDLMASKAVLQKF" }, { "InterPro": [ { "InterPro-ID": "IPR003884", "InterPro-Name": "FacI_MAC", "InterPro-Type": "DOMAIN", "Beg": 861, "End": 934 }, { "InterPro-ID": "IPR003884", "InterPro-Name": "FacI_MAC", "InterPro-Type": "DOMAIN", "Beg": 767, "End": 839 }, { "InterPro-ID": "IPR000884", "InterPro-Name": "TSP1_rpt", "InterPro-Type": "REPEAT", "Beg": 26, "End": 79 }, { "InterPro-ID": "IPR000884", "InterPro-Name": "TSP1_rpt", "InterPro-Type": "REPEAT", "Beg": 84, "End": 134 }, { "InterPro-ID": "IPR000884", "InterPro-Name": "TSP1_rpt", "InterPro-Type": "REPEAT", "Beg": 568, "End": 617 }, { "InterPro-ID": "IPR000884", "InterPro-Name": "TSP1_rpt", "InterPro-Type": "REPEAT", "Beg": 22, "End": 79 }, { "InterPro-ID": "IPR035976", "InterPro-Name": "Sushi/SCR/CCP_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 699, "End": 754 }, { "InterPro-ID": "IPR000884", "InterPro-Name": "TSP1_rpt", "InterPro-Type": "REPEAT", "Beg": 87, "End": 133 }, { "InterPro-ID": "IPR000884", "InterPro-Name": "TSP1_rpt", "InterPro-Type": "REPEAT", "Beg": 571, "End": 612 }, { "InterPro-ID": "IPR000884", "InterPro-Name": "TSP1_rpt", "InterPro-Type": "REPEAT", "Beg": 28, "End": 78 }, { "InterPro-ID": "IPR001862", "InterPro-Name": "MAC_perforin", "InterPro-Type": "FAMILY", "Beg": 500, "End": 519 }, { "InterPro-ID": "IPR001862", "InterPro-Name": "MAC_perforin", "InterPro-Type": "FAMILY", "Beg": 523, "End": 543 }, { "InterPro-ID": "IPR001862", "InterPro-Name": "MAC_perforin", "InterPro-Type": "FAMILY", "Beg": 144, "End": 164 }, { "InterPro-ID": "IPR001862", "InterPro-Name": "MAC_perforin", "InterPro-Type": "FAMILY", "Beg": 101, "End": 117 }, { "InterPro-ID": "IPR001862", "InterPro-Name": "MAC_perforin", "InterPro-Type": "FAMILY", "Beg": 343, "End": 365 }, { "InterPro-ID": "IPR001862", "InterPro-Name": "MAC_perforin", "InterPro-Type": "FAMILY", "Beg": 471, "End": 490 }, { "InterPro-ID": "IPR048831", "InterPro-Name": "C8A_B_C6_EGF-like", "InterPro-Type": "DOMAIN", "Beg": 526, "End": 554 }, { "InterPro-ID": "IPR000436", "InterPro-Name": "Sushi_SCR_CCP_dom", "InterPro-Type": "DOMAIN", "Beg": 704, "End": 762 }, { "InterPro-ID": "IPR002172", "InterPro-Name": "LDrepeatLR_classA_rpt", "InterPro-Type": "REPEAT", "Beg": 139, "End": 174 }, { "InterPro-ID": "IPR000884", "InterPro-Name": "TSP1_rpt", "InterPro-Type": "REPEAT", "Beg": 81, "End": 134 }, { "InterPro-ID": "IPR000436", "InterPro-Name": "Sushi_SCR_CCP_dom", "InterPro-Type": "DOMAIN", "Beg": 644, "End": 700 }, { "InterPro-ID": "IPR000436", "InterPro-Name": "Sushi_SCR_CCP_dom", "InterPro-Type": "DOMAIN", "Beg": 644, "End": 699 }, { "InterPro-ID": "IPR000436", "InterPro-Name": "Sushi_SCR_CCP_dom", "InterPro-Type": "DOMAIN", "Beg": 719, "End": 755 }, { "InterPro-ID": "IPR036383", "InterPro-Name": "TSP1_rpt_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 80, "End": 128 }, { "InterPro-ID": "IPR036055", "InterPro-Name": "LDL_receptor-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 136, "End": 178 }, { "InterPro-ID": "IPR000436", "InterPro-Name": "Sushi_SCR_CCP_dom", "InterPro-Type": "DOMAIN", "Beg": 702, "End": 763 }, { "InterPro-ID": "IPR020864", "InterPro-Name": "MACPF", "InterPro-Type": "DOMAIN", "Beg": 312, "End": 516 }, { "InterPro-ID": "IPR020864", "InterPro-Name": "MACPF", "InterPro-Type": "DOMAIN", "Beg": 176, "End": 522 }, { "InterPro-ID": "IPR002172", "InterPro-Name": "LDrepeatLR_classA_rpt", "InterPro-Type": "REPEAT", "Beg": 139, "End": 173 }, { "InterPro-ID": "IPR020864", "InterPro-Name": "MACPF", "InterPro-Type": "DOMAIN", "Beg": 295, "End": 514 }, { "InterPro-ID": "IPR036383", "InterPro-Name": "TSP1_rpt_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 22, "End": 79 }, { "InterPro-ID": "IPR036383", "InterPro-Name": "TSP1_rpt_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 563, "End": 614 }, { "InterPro-ID": "IPR023415", "InterPro-Name": "LDLR_class-A_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 151, "End": 173 }, { "InterPro-ID": "IPR035976", "InterPro-Name": "Sushi/SCR/CCP_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 644, "End": 707 }, { "InterPro-ID": "IPR002172", "InterPro-Name": "LDrepeatLR_classA_rpt", "InterPro-Type": "REPEAT", "Beg": 139, "End": 175 }, { "InterPro-ID": "IPR036383", "InterPro-Name": "TSP1_rpt_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 24, "End": 78 }, { "InterPro-ID": "IPR036383", "InterPro-Name": "TSP1_rpt_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 564, "End": 612 }, { "InterPro-ID": "IPR036055", "InterPro-Name": "LDL_receptor-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 138, "End": 173 }, { "InterPro-ID": "IPR020863", "InterPro-Name": "MACPF_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 354, "End": 365 }, { "InterPro-ID": "IPR000436", "InterPro-Name": "Sushi_SCR_CCP_dom", "InterPro-Type": "DOMAIN", "Beg": 642, "End": 701 }, { "InterPro-ID": "IPR002172", "InterPro-Name": "LDrepeatLR_classA_rpt", "InterPro-Type": "REPEAT", "Beg": 142, "End": 173 }, { "InterPro-ID": "IPR000436", "InterPro-Name": "Sushi_SCR_CCP_dom", "InterPro-Type": "DOMAIN", "Beg": 704, "End": 761 }, { "InterPro-ID": "IPR048828", "InterPro-Name": "C6_KAZAL", "InterPro-Type": "DOMAIN", "Beg": 785, "End": 838 }, { "InterPro-ID": "IPR002350", "InterPro-Name": "Kazal_dom", "InterPro-Type": "DOMAIN", "Beg": 785, "End": 839 }, { "InterPro-ID": "IPR000884", "InterPro-Name": "TSP1_rpt", "InterPro-Type": "REPEAT", "Beg": 565, "End": 615 } ], "response#1": "MTRHLTLCFILLVMLIDKSEACFCDHYPWTHWSSCSKSCNSGTQSRQRQVVVNDYYWKNLCDKLCIKQETRECNLQTCPINCVLGDYGTWSDCDPCTEKQVKVKSVLRPSQFGGQPCTEPLVTFQPCVPSKLCKIEETNCKNKFLCDSGRCIPSKLECNGENDCGDNSDERNCGRTKPVCTRIYTPIPSVQLMGTGFHFLAGEPRGEVLDNSFTGGICKLVKTSRASNPYRVSANLENVNFEVQTIEDDLKTEFYKNLISFEKNKNEDSLSVDERTKFFPIPIFHFSEKNEHSHYSSAFNKVIKASHKKDSSFIRIHKLIKVLNFTMKATDLQLSDVFLKALVHLPLEYNSAVYSRIFDDFGTHYFTSGSLGGKYDLIYQFSRQELQNSGLTEEEAQNCVQYETKKLKFLYMEIHKEDTCTKNKLSEKYGGSFLQGSEKSISLVQGGRSQQAAALAWEKGTSGPEENVYSEWLESVKENPAVVDYKLAPITDLVRNIPCAVTKRNNLRRALQEYAAKFDPCQCAPCPNNGRPRLSGTECLCVCQSGTYGENCERRSPGYKSDAVDGNWGCWSSWSACNAAYRRSRTRECNNPAPQRGGQSCGGKDQQEEDCTVSIMENVGQPCINDDEEMKEVDLAEPEAESGCSQPPLPENAFTWNEKKLYSVGEEVEISCLTGFTAVGFQYLRCLPDRTWSQGDVECQRTSCLKPVVQDVLTISPFQRVYQIGESIELTCPRGFVVAGPSRYTCKEDSWTPPISNSLTCEQAILTKSKDLCPPGQKQSGSKCICMSPEEDCSAYSEDLCIFDGGSSQYFTSSACKFLAGKCLNNTQSHFVHSGSCQEGLQLEWGLERLKLAVNSTKRVSCGYNTCYDWENCSAHTSNCVCLLPPQCSKDENQLYCVKIGSSMREKTVNICTLGAVRCANIKVEILNPGRCPD", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more FacI_MAC, FacI_MAC, C8A_B_C6_EGF-like, Sushi_SCR_CCP_dom, Sushi_SCR_CCP_dom, Sushi_SCR_CCP_dom, Sushi_SCR_CCP_dom, Sushi_SCR_CCP_dom, MACPF, MACPF, MACPF, Sushi_SCR_CCP_dom, Sushi_SCR_CCP_dom, C6_KAZAL, Kazal_dom that are essential for its biological function; 2. The protein should belong to MAC_perforin, MAC_perforin, MAC_perforin, MAC_perforin, MAC_perforin, MAC_perforin that shares evolutionary origin and functional similarity; 3. The protein should be classified within Sushi/SCR/CCP_sf, TSP1_rpt_sf, LDL_receptor-like_sf, TSP1_rpt_sf, TSP1_rpt_sf, Sushi/SCR/CCP_sf, TSP1_rpt_sf, TSP1_rpt_sf, LDL_receptor-like_sf sharing conserved structural features; 4. The protein should include one or more TSP1_rpt, TSP1_rpt, TSP1_rpt, TSP1_rpt, TSP1_rpt, TSP1_rpt, TSP1_rpt, LDrepeatLR_classA_rpt, TSP1_rpt, LDrepeatLR_classA_rpt, LDrepeatLR_classA_rpt, LDrepeatLR_classA_rpt, TSP1_rpt that provide structural or functional support; 5. The protein should contain LDLR_class-A_CS, MACPF_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MTRHLTLCFILLVMLIDKSEACFCDHYPWTHWSSCSKSCNSGTQSRQRQVVVNDYYWKNLCDKLCIKQETRECNLQTCPINCVLGDYGTWSDCDPCTEKQVKVKSVLRPSQFGGQPCTEPLVTFQPCVPSKLCKIEETNCKNKFLCDSGRCIPSKLECNGENDCGDNSDERNCGRTKPVCTRIYTPIPSVQLMGTGFHFLAGEPRGEVLDNSFTGGICKLVKTSRASNPYRVSANLENVNFEVQTIEDDLKTEFYKNLISFEKNKNEDSLSVDERTKFFPIPIFHFSEKNEHSHYSSAFNKVIKASHKKDSSFIRIHKLIKVLNFTMKATDLQLSDVFLKALVHLPLEYNSAVYSRIFDDFGTHYFTSGSLGGKYDLIYQFSRQELQNSGLTEEEAQNCVQYETKKLKFLYMEIHKEDTCTKNKLSEKYGGSFLQGSEKSISLVQGGRSQQAAALAWEKGTSGPEENVYSEWLESVKENPAVVDYKLAPITDLVRNIPCAVTKRNNLRRALQEYAAKFDPCQCAPCPNNGRPRLSGTECLCVCQSGTYGENCERRSPGYKSDAVDGNWGCWSSWSACNAAYRRSRTRECNNPAPQRGGQSCGGKDQQEEDCTVSIMENVGQPCINDDEEMKEVDLAEPEAESGCSQPPLPENAFTWNEKKLYSVGEEVEISCLTGFTAVGFQYLRCLPDRTWSQGDVECQRTSCLKPVVQDVLTISPFQRVYQIGESIELTCPRGFVVAGPSRYTCKEDSWTPPISNSLTCEQAILTKSKDLCPPGQKQSGSKCICMSPEEDCSAYSEDLCIFDGGSSQYFTSSACKFLAGKCLNNTQSHFVHSGSCQEGLQLEWGLERLKLAVNSTKRVSCGYNTCYDWENCSAHTSNCVCLLPPQCSKDENQLYCVKIGSSMREKTVNICTLGAVRCANIKVEILNPGRCPD" }, { "InterPro": [ { "InterPro-ID": "IPR000276", "InterPro-Name": "GPCR_Rhodpsn", "InterPro-Type": "FAMILY", "Beg": 35, "End": 286 }, { "InterPro-ID": "IPR017452", "InterPro-Name": "GPCR_Rhodpsn_7TM", "InterPro-Type": "DOMAIN", "Beg": 34, "End": 286 }, { "InterPro-ID": "IPR002276", "InterPro-Name": "GPR4_orph", "InterPro-Type": "FAMILY", "Beg": 174, "End": 183 }, { "InterPro-ID": "IPR002276", "InterPro-Name": "GPR4_orph", "InterPro-Type": "FAMILY", "Beg": 124, "End": 136 }, { "InterPro-ID": "IPR002276", "InterPro-Name": "GPR4_orph", "InterPro-Type": "FAMILY", "Beg": 246, "End": 261 }, { "InterPro-ID": "IPR002276", "InterPro-Name": "GPR4_orph", "InterPro-Type": "FAMILY", "Beg": 1, "End": 22 }, { "InterPro-ID": "IPR002276", "InterPro-Name": "GPR4_orph", "InterPro-Type": "FAMILY", "Beg": 320, "End": 338 }, { "InterPro-ID": "IPR002276", "InterPro-Name": "GPR4_orph", "InterPro-Type": "FAMILY", "Beg": 148, "End": 166 }, { "InterPro-ID": "IPR002276", "InterPro-Name": "GPR4_orph", "InterPro-Type": "FAMILY", "Beg": 208, "End": 220 }, { "InterPro-ID": "IPR000276", "InterPro-Name": "GPCR_Rhodpsn", "InterPro-Type": "FAMILY", "Beg": 19, "End": 43 }, { "InterPro-ID": "IPR000276", "InterPro-Name": "GPCR_Rhodpsn", "InterPro-Type": "FAMILY", "Beg": 52, "End": 73 }, { "InterPro-ID": "IPR000276", "InterPro-Name": "GPCR_Rhodpsn", "InterPro-Type": "FAMILY", "Beg": 182, "End": 205 }, { "InterPro-ID": "IPR000276", "InterPro-Name": "GPCR_Rhodpsn", "InterPro-Type": "FAMILY", "Beg": 97, "End": 119 }, { "InterPro-ID": "IPR000276", "InterPro-Name": "GPCR_Rhodpsn", "InterPro-Type": "FAMILY", "Beg": 133, "End": 154 }, { "InterPro-ID": "IPR000276", "InterPro-Name": "GPCR_Rhodpsn", "InterPro-Type": "FAMILY", "Beg": 268, "End": 294 }, { "InterPro-ID": "IPR000276", "InterPro-Name": "GPCR_Rhodpsn", "InterPro-Type": "FAMILY", "Beg": 222, "End": 246 }, { "InterPro-ID": "IPR000276", "InterPro-Name": "GPCR_Rhodpsn", "InterPro-Type": "FAMILY", "Beg": 103, "End": 119 } ], "response#1": "MCNVSQDSCNIDSRLDSLFPPTLYIFVMVIGFPTNCLSLWAAFVQVRQKNELGVYLLNLSISDLLYIATLPPWVNYFLHQDNWIHGPESCKLFGFILYTNIYISIGFLSCISVDRYLAVAHPLKFAKVRRVKTAAVVSAVVWAIEIGANSAPLFHNELFEDRFNHTFCFEKYPMEDWVAQMNLYRVFVGFLFPWVLMLFCYQGILRAVKTNVSTEREEKAKIKRLALSLIAILLFCFAPYHLILLSRSVVYLGQPCDCTFEENIFTAYHVSLALTSLNCVADPILYCLANEGARSEVTRGLAPLMKFFSASRPNMDSFARSVTLDTPWSSRRAAAPSPRSWSLCGQTGGRGRRSRVRRRRDCKC", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more GPCR_Rhodpsn_7TM that are essential for its biological function; 2. The protein should belong to GPCR_Rhodpsn, GPR4_orph, GPR4_orph, GPR4_orph, GPR4_orph, GPR4_orph, GPR4_orph, GPR4_orph, GPCR_Rhodpsn, GPCR_Rhodpsn, GPCR_Rhodpsn, GPCR_Rhodpsn, GPCR_Rhodpsn, GPCR_Rhodpsn, GPCR_Rhodpsn, GPCR_Rhodpsn that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MCNVSQDSCNIDSRLDSLFPPTLYIFVMVIGFPTNCLSLWAAFVQVRQKNELGVYLLNLSISDLLYIATLPPWVNYFLHQDNWIHGPESCKLFGFILYTNIYISIGFLSCISVDRYLAVAHPLKFAKVRRVKTAAVVSAVVWAIEIGANSAPLFHNELFEDRFNHTFCFEKYPMEDWVAQMNLYRVFVGFLFPWVLMLFCYQGILRAVKTNVSTEREEKAKIKRLALSLIAILLFCFAPYHLILLSRSVVYLGQPCDCTFEENIFTAYHVSLALTSLNCVADPILYCLANEGARSEVTRGLAPLMKFFSASRPNMDSFARSVTLDTPWSSRRAAAPSPRSWSLCGQTGGRGRRSRVRRRRDCKC" }, { "InterPro": [ { "InterPro-ID": "IPR036396", "InterPro-Name": "Cyt_P450_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 79, "End": 522 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 460, "End": 470 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 339, "End": 365 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 424, "End": 448 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 470, "End": 493 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 90, "End": 109 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 319, "End": 336 }, { "InterPro-ID": "IPR050665", "InterPro-Name": "Cytochrome_P450_Monooxygen", "InterPro-Type": "FAMILY", "Beg": 19, "End": 515 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 330, "End": 347 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 461, "End": 470 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 383, "End": 394 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 470, "End": 481 }, { "InterPro-ID": "IPR017972", "InterPro-Name": "Cyt_P450_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 463, "End": 472 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 85, "End": 497 }, { "InterPro-ID": "IPR036396", "InterPro-Name": "Cyt_P450_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 29, "End": 522 } ], "response#1": "MEYLPYIATSIACIVILRWALNMMQWLWFEPRRLEKLLRKQGLQGNSYKFLFGDMKESSMLRNEALAKPMPMPFDNDYFPRINPFVDQLLNKYGMNCFLWMGPVPAIQIGEPELVREAFNRMHEFQKPKTNPLSALLATGLVSYEGDKWAKHRRLINPSFHVEKLKLMIPAFRESIVEVVNQWEKKVPENGSAEIDVWPSLTSLTGDVISRAAFGSVYGDGRRIFELLAVQKELVLSLLKFSYIPGYTYLPTEGNKKMKAVNNEIQRLLENVIQNRKKAMEAGEAAKDDLLGLLMDSNYKESMLEGGGKNKKLIMSFQDLIDECKLFFLAGHETTAVLLVWTLILLCKHQDWQTKAREEVLATFGMSEPTDYDALNRLKIVTMILNEVLRLYPPVVSTNRKLFKGETKLGNLVIPPGVGISLLTIQANRDPKVWGEDASEFRPDRFAEGLVKATKGNVAFFPFGWGPRICIGQNFALTESKMAVAMILQRFTFDLSPSYTHAPSGLITLNPQYGAPLMFRRR", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Cyt_P450_E_grp-I, Cyt_P450_E_grp-I, Cyt_P450_E_grp-I, Cyt_P450_E_grp-I, Cyt_P450_E_grp-I, Cyt_P450_E_grp-I, Cytochrome_P450_Monooxygen, Cyt_P450, Cyt_P450, Cyt_P450, Cyt_P450, Cyt_P450 that shares evolutionary origin and functional similarity; 2. The protein should be classified within Cyt_P450_sf, Cyt_P450_sf sharing conserved structural features; 3. The protein should contain Cyt_P450_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MEYLPYIATSIACIVILRWALNMMQWLWFEPRRLEKLLRKQGLQGNSYKFLFGDMKESSMLRNEALAKPMPMPFDNDYFPRINPFVDQLLNKYGMNCFLWMGPVPAIQIGEPELVREAFNRMHEFQKPKTNPLSALLATGLVSYEGDKWAKHRRLINPSFHVEKLKLMIPAFRESIVEVVNQWEKKVPENGSAEIDVWPSLTSLTGDVISRAAFGSVYGDGRRIFELLAVQKELVLSLLKFSYIPGYTYLPTEGNKKMKAVNNEIQRLLENVIQNRKKAMEAGEAAKDDLLGLLMDSNYKESMLEGGGKNKKLIMSFQDLIDECKLFFLAGHETTAVLLVWTLILLCKHQDWQTKAREEVLATFGMSEPTDYDALNRLKIVTMILNEVLRLYPPVVSTNRKLFKGETKLGNLVIPPGVGISLLTIQANRDPKVWGEDASEFRPDRFAEGLVKATKGNVAFFPFGWGPRICIGQNFALTESKMAVAMILQRFTFDLSPSYTHAPSGLITLNPQYGAPLMFRRR" }, { "InterPro": [ { "InterPro-ID": "IPR014756", "InterPro-Name": "Ig_E-set", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 145, "End": 334 }, { "InterPro-ID": "IPR016449", "InterPro-Name": "K_chnl_inward-rec_Kir", "InterPro-Type": "FAMILY", "Beg": 14, "End": 333 }, { "InterPro-ID": "IPR008062", "InterPro-Name": "KCNJ13", "InterPro-Type": "FAMILY", "Beg": 1, "End": 20 }, { "InterPro-ID": "IPR008062", "InterPro-Name": "KCNJ13", "InterPro-Type": "FAMILY", "Beg": 344, "End": 360 }, { "InterPro-ID": "IPR008062", "InterPro-Name": "KCNJ13", "InterPro-Type": "FAMILY", "Beg": 171, "End": 188 }, { "InterPro-ID": "IPR008062", "InterPro-Name": "KCNJ13", "InterPro-Type": "FAMILY", "Beg": 22, "End": 37 }, { "InterPro-ID": "IPR013518", "InterPro-Name": "K_chnl_inward-rec_Kir_cyto", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 19, "End": 331 }, { "InterPro-ID": "IPR041647", "InterPro-Name": "IRK_C", "InterPro-Type": "DOMAIN", "Beg": 170, "End": 331 }, { "InterPro-ID": "IPR016449", "InterPro-Name": "K_chnl_inward-rec_Kir", "InterPro-Type": "FAMILY", "Beg": 53, "End": 79 }, { "InterPro-ID": "IPR016449", "InterPro-Name": "K_chnl_inward-rec_Kir", "InterPro-Type": "FAMILY", "Beg": 235, "End": 253 }, { "InterPro-ID": "IPR016449", "InterPro-Name": "K_chnl_inward-rec_Kir", "InterPro-Type": "FAMILY", "Beg": 265, "End": 285 }, { "InterPro-ID": "IPR016449", "InterPro-Name": "K_chnl_inward-rec_Kir", "InterPro-Type": "FAMILY", "Beg": 286, "End": 303 }, { "InterPro-ID": "IPR016449", "InterPro-Name": "K_chnl_inward-rec_Kir", "InterPro-Type": "FAMILY", "Beg": 311, "End": 325 }, { "InterPro-ID": "IPR016449", "InterPro-Name": "K_chnl_inward-rec_Kir", "InterPro-Type": "FAMILY", "Beg": 109, "End": 131 }, { "InterPro-ID": "IPR040445", "InterPro-Name": "Kir_TM", "InterPro-Type": "DOMAIN", "Beg": 21, "End": 163 }, { "InterPro-ID": "IPR016449", "InterPro-Name": "K_chnl_inward-rec_Kir", "InterPro-Type": "FAMILY", "Beg": 3, "End": 359 } ], "response#1": "MDGSHCKVIAPLLTERHQRMVTKDGHSTLQMDGAQTGLAYLRDAWGILMDMRWRWMMLVFSASFVIHWLVFAVLWYILAEMNGDLGLDHDAPPENHTICVKYITSFTAAFSFSLETQLTIGYGTMFPSGDCPSAIALLAIQMLLGLMLEAFITGAFVAKIARPKNRAFSIRFTDLAVVAHIDGKPNLIFQVANTRPSPLTNVRVSAVLYQERENGKLYQTSVDFHLDGISSEECPFFIFPLTYYHSIIPSSPLATLLQHENPPHFELVVFLSAMQEGTGETCQRRTSYLPSEIMLHHCFASLLARGSKGEYQIKMENFDKTTPEFQTPLVSKSPNRTDLDIHINGQSIDNFQISETGLTE", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more IRK_C, Kir_TM that are essential for its biological function; 2. The protein should belong to K_chnl_inward-rec_Kir, KCNJ13, KCNJ13, KCNJ13, KCNJ13, K_chnl_inward-rec_Kir, K_chnl_inward-rec_Kir, K_chnl_inward-rec_Kir, K_chnl_inward-rec_Kir, K_chnl_inward-rec_Kir, K_chnl_inward-rec_Kir, K_chnl_inward-rec_Kir that shares evolutionary origin and functional similarity; 3. The protein should be classified within Ig_E-set, K_chnl_inward-rec_Kir_cyto sharing conserved structural features. The designed protein sequence is ", "reference": "MDGSHCKVIAPLLTERHQRMVTKDGHSTLQMDGAQTGLAYLRDAWGILMDMRWRWMMLVFSASFVIHWLVFAVLWYILAEMNGDLGLDHDAPPENHTICVKYITSFTAAFSFSLETQLTIGYGTMFPSGDCPSAIALLAIQMLLGLMLEAFITGAFVAKIARPKNRAFSIRFTDLAVVAHIDGKPNLIFQVANTRPSPLTNVRVSAVLYQERENGKLYQTSVDFHLDGISSEECPFFIFPLTYYHSIIPSSPLATLLQHENPPHFELVVFLSAMQEGTGETCQRRTSYLPSEIMLHHCFASLLARGSKGEYQIKMENFDKTTPEFQTPLVSKSPNRTDLDIHINGQSIDNFQISETGLTE" }, { "InterPro": [ { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 123, "End": 158 } ], "response#1": "MAQRPSVPIAIIGNYISRRRQVSLEEAEALAQGLKCRFLGEVHAIRDGPYSYADGTLESILNLYRDAFFGDFDSETGEHRKEKEFKGEVLSSGLKDIAKQKRHKLANIFMNPKPPKYRSSTSLGGIATGCSPRSVVGVGGGNRCAHRPVCCTDNKFSECLPL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Hydrophobin that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MAQRPSVPIAIIGNYISRRRQVSLEEAEALAQGLKCRFLGEVHAIRDGPYSYADGTLESILNLYRDAFFGDFDSETGEHRKEKEFKGEVLSSGLKDIAKQKRHKLANIFMNPKPPKYRSSTSLGGIATGCSPRSVVGVGGGNRCAHRPVCCTDNKFSECLPL" }, { "InterPro": [ { "InterPro-ID": "IPR029312", "InterPro-Name": "FANCI_HD2", "InterPro-Type": "DOMAIN", "Beg": 557, "End": 789 }, { "InterPro-ID": "IPR029308", "InterPro-Name": "FANCI_S1", "InterPro-Type": "DOMAIN", "Beg": 64, "End": 281 }, { "InterPro-ID": "IPR026171", "InterPro-Name": "FANCI", "InterPro-Type": "FAMILY", "Beg": 41, "End": 1295 }, { "InterPro-ID": "IPR029315", "InterPro-Name": "FANCI_S2", "InterPro-Type": "DOMAIN", "Beg": 380, "End": 543 }, { "InterPro-ID": "IPR029310", "InterPro-Name": "FANCI_HD1", "InterPro-Type": "DOMAIN", "Beg": 287, "End": 372 }, { "InterPro-ID": "IPR029314", "InterPro-Name": "FANCI_S4", "InterPro-Type": "DOMAIN", "Beg": 1044, "End": 1297 }, { "InterPro-ID": "IPR029305", "InterPro-Name": "FANCI_S1-cap", "InterPro-Type": "DOMAIN", "Beg": 1, "End": 53 }, { "InterPro-ID": "IPR029313", "InterPro-Name": "FANCI_S3", "InterPro-Type": "DOMAIN", "Beg": 807, "End": 1031 }, { "InterPro-ID": "IPR026171", "InterPro-Name": "FANCI", "InterPro-Type": "FAMILY", "Beg": 2, "End": 1338 } ], "response#1": "MAQRILQLAAEGSPERLQEALQGLTEGELGDMVTRQALRGRETAALLKGIFKGSPCSQQSGVLRRLQVYKHCVSLVESGDLHVGKVSEIIGLLMLEARQLPGHALAELATLFVEVIKRGSLSNGKSLELFSTVLTALSNSKESLAYGKGELNGEEFKKQLINTLCSSKWDPQCVIHLANMFRDIPLSGEELQFVVEKVLRMFSKLDLQEIPPLVYQLLLLSAKGSKKTVLEGIISFFNQLDKRQKEEQRVPQSADLEVATVPLDQLRHVEGTVILHIVSAINLDQDIGEELIKHLKTEQQKDPGKALCPFSVSLLLSTAVKHRLQEQIFDFLKTSITRSCKDLQILQASKFLQDLCPQQYDVTAVILEVVKNSAFGWDHVTQGLVDLGFSLMESYEPKKSFGGKAAETNLGLSKMPAQQACKLGASILLETFKVHEPIRSDILEQVLNRVLTKAASPVSHFIDLLSNIVVSAPLVLQNSSSRVTETFDNLSFLPIDTVQGLLRAVQPLLKVSMSVRDSLILVLQKAIFSRQLDARKAAVAGFLLLLRNFKILGSLTSSQCSQAIGATQVQADVHACYNSAANEAFCLEILGSLRRCLSQQADVRLMLYEGFYDVLRRNSQLASSIMETLLSQIKQYYLPQQDLLPPLKLEGCIMAQGDQIFLQEPLAHLLCCIQHCLAWYKSTVHLCKGAEDEEEEEDVGFEQNFEEMLESVTRRMIKSELEDFELDKSADFSPSSGVGVKNNIYAIQVMGICEVLIEYNFKIGNFSKNKFEDVLGLFTCYNKLSEILKEKAGKNKSTLGNRIARSFLSMGFVSTLLTALFRDNAQSHEESLAVLRSSTEFMRYAVSVALQKVQQLEEMGQTDGPDGQNPEKMFQNLCKITRVLLWRYTSIPTAVEESGKKKGKSISLLCLEGLLRIFNTMQQLYAARIPQFLQALDITDGDAEEADINVTEKAAFQIRQFQRSLVNQLSSAEDDFNSKETQLLITILSTLSKLLDPGSQQFLQFLTWTVKICKENALEDLSCCKGLLTLLFSLHVLYKSPVSLLRELAQDIHACLGDIDQDVEIESRSHFAIVNVKTAAPTVCLLVLGQADKVLEEVDWLIKRLTILGSDTSEDSTQASNQTQALEKGVILQLGTLLTVFHELVQTALPAGSCVDSLLRSLSKTYAILTSLIKHYIQACRSTSNTVPGRLEKLVKLSGSHLTPQCYSFITYVQNIHSESLSFAEEKKKKKKEDETAVVSTVMAKVLRDTKPIPNLIFAIEQYEKFLIHLSKKSKVNLMQYMKLSTSRDFRINASMLDSVLQEQNTEDAENEPDNNQSGTAEQPDENQEPQKKRRRKK", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more FANCI_HD2, FANCI_S1, FANCI_S2, FANCI_HD1, FANCI_S4, FANCI_S1-cap, FANCI_S3 that are essential for its biological function; 2. The protein should belong to FANCI, FANCI that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MAQRILQLAAEGSPERLQEALQGLTEGELGDMVTRQALRGRETAALLKGIFKGSPCSQQSGVLRRLQVYKHCVSLVESGDLHVGKVSEIIGLLMLEARQLPGHALAELATLFVEVIKRGSLSNGKSLELFSTVLTALSNSKESLAYGKGELNGEEFKKQLINTLCSSKWDPQCVIHLANMFRDIPLSGEELQFVVEKVLRMFSKLDLQEIPPLVYQLLLLSAKGSKKTVLEGIISFFNQLDKRQKEEQRVPQSADLEVATVPLDQLRHVEGTVILHIVSAINLDQDIGEELIKHLKTEQQKDPGKALCPFSVSLLLSTAVKHRLQEQIFDFLKTSITRSCKDLQILQASKFLQDLCPQQYDVTAVILEVVKNSAFGWDHVTQGLVDLGFSLMESYEPKKSFGGKAAETNLGLSKMPAQQACKLGASILLETFKVHEPIRSDILEQVLNRVLTKAASPVSHFIDLLSNIVVSAPLVLQNSSSRVTETFDNLSFLPIDTVQGLLRAVQPLLKVSMSVRDSLILVLQKAIFSRQLDARKAAVAGFLLLLRNFKILGSLTSSQCSQAIGATQVQADVHACYNSAANEAFCLEILGSLRRCLSQQADVRLMLYEGFYDVLRRNSQLASSIMETLLSQIKQYYLPQQDLLPPLKLEGCIMAQGDQIFLQEPLAHLLCCIQHCLAWYKSTVHLCKGAEDEEEEEDVGFEQNFEEMLESVTRRMIKSELEDFELDKSADFSPSSGVGVKNNIYAIQVMGICEVLIEYNFKIGNFSKNKFEDVLGLFTCYNKLSEILKEKAGKNKSTLGNRIARSFLSMGFVSTLLTALFRDNAQSHEESLAVLRSSTEFMRYAVSVALQKVQQLEEMGQTDGPDGQNPEKMFQNLCKITRVLLWRYTSIPTAVEESGKKKGKSISLLCLEGLLRIFNTMQQLYAARIPQFLQALDITDGDAEEADINVTEKAAFQIRQFQRSLVNQLSSAEDDFNSKETQLLITILSTLSKLLDPGSQQFLQFLTWTVKICKENALEDLSCCKGLLTLLFSLHVLYKSPVSLLRELAQDIHACLGDIDQDVEIESRSHFAIVNVKTAAPTVCLLVLGQADKVLEEVDWLIKRLTILGSDTSEDSTQASNQTQALEKGVILQLGTLLTVFHELVQTALPAGSCVDSLLRSLSKTYAILTSLIKHYIQACRSTSNTVPGRLEKLVKLSGSHLTPQCYSFITYVQNIHSESLSFAEEKKKKKKEDETAVVSTVMAKVLRDTKPIPNLIFAIEQYEKFLIHLSKKSKVNLMQYMKLSTSRDFRINASMLDSVLQEQNTEDAENEPDNNQSGTAEQPDENQEPQKKRRRKK" }, { "InterPro": [ { "InterPro-ID": "IPR050481", "InterPro-Name": "UDP-glycosyltransf_plant", "InterPro-Type": "FAMILY", "Beg": 6, "End": 435 }, { "InterPro-ID": "IPR002213", "InterPro-Name": "UDP_glucos_trans", "InterPro-Type": "FAMILY", "Beg": 312, "End": 397 }, { "InterPro-ID": "IPR035595", "InterPro-Name": "UDP_glycos_trans_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 312, "End": 355 }, { "InterPro-ID": "IPR002213", "InterPro-Name": "UDP_glucos_trans", "InterPro-Type": "FAMILY", "Beg": 6, "End": 405 } ], "response#1": "MGTKELHIVMYPWLAFGHFIPYLHLSNKLAQKGHKITFLLPHRAKLQLDSQNLYPSLITLVPITVPQVDTLPLGAESTADIPLSQHGDLSIAMDRTRPEIESILSKLDPKPDLIFFDMAQWVPVIASKLGIKSVSYNIVCAISLDLVRDWYKKDDGSNVPSWTLKHDKSSHFGENISILERALIALGTPDAIGIRSCREIEGEYCDSIAERFKKPVLLSGTTLPEPSDDPLDPKWVKWLGKFEEGSVIFCCLGSQHVLDKPQLQELALGLEMTGLPFFLAIKPPLGYATLDEVLPEGFSERVRDRGVAHGGWVQQPQMLAHPSVGCFLCHCGSSSMWEALVSDTQLVLFPQIPDQALNAVLMADKLKVGVKVEREDDGGVSKEVWSRAIKSVMDKESEIAAEVKKNHTKWRDMLINEEFVNGYIDSFIKDLQDLVEK", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to UDP-glycosyltransf_plant, UDP_glucos_trans, UDP_glucos_trans that shares evolutionary origin and functional similarity; 2. The protein should contain UDP_glycos_trans_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MGTKELHIVMYPWLAFGHFIPYLHLSNKLAQKGHKITFLLPHRAKLQLDSQNLYPSLITLVPITVPQVDTLPLGAESTADIPLSQHGDLSIAMDRTRPEIESILSKLDPKPDLIFFDMAQWVPVIASKLGIKSVSYNIVCAISLDLVRDWYKKDDGSNVPSWTLKHDKSSHFGENISILERALIALGTPDAIGIRSCREIEGEYCDSIAERFKKPVLLSGTTLPEPSDDPLDPKWVKWLGKFEEGSVIFCCLGSQHVLDKPQLQELALGLEMTGLPFFLAIKPPLGYATLDEVLPEGFSERVRDRGVAHGGWVQQPQMLAHPSVGCFLCHCGSSSMWEALVSDTQLVLFPQIPDQALNAVLMADKLKVGVKVEREDDGGVSKEVWSRAIKSVMDKESEIAAEVKKNHTKWRDMLINEEFVNGYIDSFIKDLQDLVEK" }, { "InterPro": [ { "InterPro-ID": "IPR036686", "InterPro-Name": "Hydrophobin_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 27, "End": 99 }, { "InterPro-ID": "IPR010636", "InterPro-Name": "Cerato-ulmin_hydrophobin", "InterPro-Type": "FAMILY", "Beg": 32, "End": 97 }, { "InterPro-ID": "IPR036686", "InterPro-Name": "Hydrophobin_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 35, "End": 98 }, { "InterPro-ID": "IPR010636", "InterPro-Name": "Cerato-ulmin_hydrophobin", "InterPro-Type": "FAMILY", "Beg": 33, "End": 97 }, { "InterPro-ID": "IPR010636", "InterPro-Name": "Cerato-ulmin_hydrophobin", "InterPro-Type": "FAMILY", "Beg": 1, "End": 98 } ], "response#1": "MQLTALLALATLAIAAPAEPSEVAPRNVLTGPCSSGVTNSNPQCCGAGILGILYFDCETPDEVSSPINPLKTICAAEGLQAKCCTLGIAGLGVLCTDALPE", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Cerato-ulmin_hydrophobin, Cerato-ulmin_hydrophobin, Cerato-ulmin_hydrophobin that shares evolutionary origin and functional similarity; 2. The protein should be classified within Hydrophobin_sf, Hydrophobin_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MQLTALLALATLAIAAPAEPSEVAPRNVLTGPCSSGVTNSNPQCCGAGILGILYFDCETPDEVSSPINPLKTICAAEGLQAKCCTLGIAGLGVLCTDALPE" }, { "InterPro": [ { "InterPro-ID": "IPR036291", "InterPro-Name": "NAD(P)-bd_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 11, "End": 227 }, { "InterPro-ID": "IPR016040", "InterPro-Name": "NAD(P)-bd_dom", "InterPro-Type": "DOMAIN", "Beg": 25, "End": 153 } ], "response#1": "MADKETLLKLREDFKMQNKSVFILGASGETGKVLLKEILGQNLFSKVTLIGRRKLTFEEEAYNNVNQEVVDFEKLDEYAPAFQGHDVGFCCLGTTRRKAGADGFVRVDRDYVLKSAELAKAGGCKHFNLLSSRGADKSSSFLYLQVKGEVEAKVEELKFDRLSVFRPGVLLCDRQESRPGEWLARKFFGSLPDSWASGYAVPVVTVVRAMLNNLVSPGSGQMELLENKAILHLGKDSDGPKL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more NAD(P)-bd_dom that are essential for its biological function; 2. The protein should be classified within NAD(P)-bd_dom_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MADKETLLKLREDFKMQNKSVFILGASGETGKVLLKEILGQNLFSKVTLIGRRKLTFEEEAYNNVNQEVVDFEKLDEYAPAFQGHDVGFCCLGTTRRKAGADGFVRVDRDYVLKSAELAKAGGCKHFNLLSSRGADKSSSFLYLQVKGEVEAKVEELKFDRLSVFRPGVLLCDRQESRPGEWLARKFFGSLPDSWASGYAVPVVTVVRAMLNNLVSPGSGQMELLENKAILHLGKDSDGPKL" }, { "InterPro": [ { "InterPro-ID": "IPR039437", "InterPro-Name": "Put_lumazine-bd", "InterPro-Type": "FAMILY", "Beg": 9, "End": 121 }, { "InterPro-ID": "IPR032710", "InterPro-Name": "NTF2-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 5, "End": 124 } ], "response#1": "MAKHITSSEYDAVIATAYCYVEAMEKGSSKRAKEGFHPDGGIYGYVDGEFKGGSISNLFDFLDQSPEGHKIKAHLDVIAMTPTTAIVKTEVEMNPPETDYTDFLGMVKIDGKWQIVSKIFHSYPR", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Put_lumazine-bd that shares evolutionary origin and functional similarity; 2. The protein should be classified within NTF2-like_dom_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MAKHITSSEYDAVIATAYCYVEAMEKGSSKRAKEGFHPDGGIYGYVDGEFKGGSISNLFDFLDQSPEGHKIKAHLDVIAMTPTTAIVKTEVEMNPPETDYTDFLGMVKIDGKWQIVSKIFHSYPR" }, { "InterPro": [ { "InterPro-ID": "IPR010636", "InterPro-Name": "Cerato-ulmin_hydrophobin", "InterPro-Type": "FAMILY", "Beg": 91, "End": 156 }, { "InterPro-ID": "IPR036686", "InterPro-Name": "Hydrophobin_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 85, "End": 159 }, { "InterPro-ID": "IPR036686", "InterPro-Name": "Hydrophobin_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 91, "End": 158 }, { "InterPro-ID": "IPR010636", "InterPro-Name": "Cerato-ulmin_hydrophobin", "InterPro-Type": "FAMILY", "Beg": 91, "End": 155 }, { "InterPro-ID": "IPR010636", "InterPro-Name": "Cerato-ulmin_hydrophobin", "InterPro-Type": "FAMILY", "Beg": 92, "End": 155 } ], "response#1": "MPASNSCSPPGGDHKPPPPPPSHPSPSPTPSYPPPPNNGGGYYPPPPDNTSHTPPPPSSTPPNNGGGGNDGGSGNTGGGNSDDGSDGGHSICPSGLYSSAQCCSTDVLGIADLNCKPPSRTPKDGSDFAKICSNTGSEARCCVIPVAGQALLCEDVVGAN", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Cerato-ulmin_hydrophobin, Cerato-ulmin_hydrophobin, Cerato-ulmin_hydrophobin that shares evolutionary origin and functional similarity; 2. The protein should be classified within Hydrophobin_sf, Hydrophobin_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MPASNSCSPPGGDHKPPPPPPSHPSPSPTPSYPPPPNNGGGYYPPPPDNTSHTPPPPSSTPPNNGGGGNDGGSGNTGGGNSDDGSDGGHSICPSGLYSSAQCCSTDVLGIADLNCKPPSRTPKDGSDFAKICSNTGSEARCCVIPVAGQALLCEDVVGAN" }, { "InterPro": [ { "InterPro-ID": "IPR001360", "InterPro-Name": "Glyco_hydro_1", "InterPro-Type": "FAMILY", "Beg": 20, "End": 195 }, { "InterPro-ID": "IPR001360", "InterPro-Name": "Glyco_hydro_1", "InterPro-Type": "FAMILY", "Beg": 232, "End": 513 }, { "InterPro-ID": "IPR017853", "InterPro-Name": "Glycoside_hydrolase_SF", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 17, "End": 510 }, { "InterPro-ID": "IPR001360", "InterPro-Name": "Glyco_hydro_1", "InterPro-Type": "FAMILY", "Beg": 440, "End": 451 }, { "InterPro-ID": "IPR001360", "InterPro-Name": "Glyco_hydro_1", "InterPro-Type": "FAMILY", "Beg": 461, "End": 478 }, { "InterPro-ID": "IPR001360", "InterPro-Name": "Glyco_hydro_1", "InterPro-Type": "FAMILY", "Beg": 341, "End": 355 }, { "InterPro-ID": "IPR001360", "InterPro-Name": "Glyco_hydro_1", "InterPro-Type": "FAMILY", "Beg": 485, "End": 497 }, { "InterPro-ID": "IPR001360", "InterPro-Name": "Glyco_hydro_1", "InterPro-Type": "FAMILY", "Beg": 417, "End": 425 }, { "InterPro-ID": "IPR001360", "InterPro-Name": "Glyco_hydro_1", "InterPro-Type": "FAMILY", "Beg": 22, "End": 514 }, { "InterPro-ID": "IPR033132", "InterPro-Name": "Glyco_hydro_1_N_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 26, "End": 40 } ], "response#1": "MSSVLPTPVLPTPGKNINRGHFPDDFIFGAGTSSYQIEGAAREGGRGPSIWDTFTHTHPELIQDGSNGDTAVNSYNLYKEDIKIVKLMGLDAYRFSISWPRILPGGSINAGINQEGIKYYNNLIDELLANDIVPYVTLFHWDVPQALQDQYDGFLSDKIVDDFRDFAELCFWEFGDRVKNWITINEPQSYSDFFGVAYDTPPKAHALKASRLLVPTTVARPSKPARVFASTADPGTTTADQVYKVGHNLLLAHAAALKVYRDNFQDTQEGTFGMALVTQWMKPLNENNPADVEAASRAFDFKFGWFMQPLITGEYPKSMRQSLGPRLREFTRDQKKLLIGSYDYVGVNYYTATYVSSARPPNDNKAIFHTDGNFYTTDCKDGVLIGPLAGPAWLNIVPEGIYRCLQEIKAKYNNPVIYITENGVYEVNDTTKTLSEARVDTTRVDYLQDHLSYVLKARQQGVRVQGYFVWSLMDNWELRAGYTSRFGLIHVDYYNNFARYPKDSAIWFRNAFHKRLRIHVNKRPQEDDGAFDTPRKRLKK", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Glyco_hydro_1, Glyco_hydro_1, Glyco_hydro_1, Glyco_hydro_1, Glyco_hydro_1, Glyco_hydro_1, Glyco_hydro_1, Glyco_hydro_1 that shares evolutionary origin and functional similarity; 2. The protein should be classified within Glycoside_hydrolase_SF sharing conserved structural features; 3. The protein should contain Glyco_hydro_1_N_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MSSVLPTPVLPTPGKNINRGHFPDDFIFGAGTSSYQIEGAAREGGRGPSIWDTFTHTHPELIQDGSNGDTAVNSYNLYKEDIKIVKLMGLDAYRFSISWPRILPGGSINAGINQEGIKYYNNLIDELLANDIVPYVTLFHWDVPQALQDQYDGFLSDKIVDDFRDFAELCFWEFGDRVKNWITINEPQSYSDFFGVAYDTPPKAHALKASRLLVPTTVARPSKPARVFASTADPGTTTADQVYKVGHNLLLAHAAALKVYRDNFQDTQEGTFGMALVTQWMKPLNENNPADVEAASRAFDFKFGWFMQPLITGEYPKSMRQSLGPRLREFTRDQKKLLIGSYDYVGVNYYTATYVSSARPPNDNKAIFHTDGNFYTTDCKDGVLIGPLAGPAWLNIVPEGIYRCLQEIKAKYNNPVIYITENGVYEVNDTTKTLSEARVDTTRVDYLQDHLSYVLKARQQGVRVQGYFVWSLMDNWELRAGYTSRFGLIHVDYYNNFARYPKDSAIWFRNAFHKRLRIHVNKRPQEDDGAFDTPRKRLKK" }, { "InterPro": [ { "InterPro-ID": "IPR000489", "InterPro-Name": "Pterin-binding_dom", "InterPro-Type": "DOMAIN", "Beg": 4, "End": 19 }, { "InterPro-ID": "IPR011005", "InterPro-Name": "Dihydropteroate_synth-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1, "End": 263 }, { "InterPro-ID": "IPR045031", "InterPro-Name": "DHP_synth-like", "InterPro-Type": "FAMILY", "Beg": 3, "End": 262 }, { "InterPro-ID": "IPR006390", "InterPro-Name": "DHP_synth_dom", "InterPro-Type": "DOMAIN", "Beg": 3, "End": 261 }, { "InterPro-ID": "IPR006390", "InterPro-Name": "DHP_synth_dom", "InterPro-Type": "DOMAIN", "Beg": 3, "End": 257 }, { "InterPro-ID": "IPR000489", "InterPro-Name": "Pterin-binding_dom", "InterPro-Type": "DOMAIN", "Beg": 5, "End": 247 }, { "InterPro-ID": "IPR000489", "InterPro-Name": "Pterin-binding_dom", "InterPro-Type": "DOMAIN", "Beg": 38, "End": 51 }, { "InterPro-ID": "IPR000489", "InterPro-Name": "Pterin-binding_dom", "InterPro-Type": "DOMAIN", "Beg": 2, "End": 257 }, { "InterPro-ID": "IPR011005", "InterPro-Name": "Dihydropteroate_synth-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 3, "End": 262 } ], "response#1": "MSKIFGIVNITTDSFSDGGLYLDTDKAIEHALHLVEDGADVIDLGAASSNPDTTEVGVVEEIKRLKPVIKALKEKGISISVDTFKPEVQSFCIEQKVDFINDIQGFPYPEIYSGLAKSDCKLVLMHSVQRIGAATKVETNPEEVFTSMMEFFKERIAALVEAGVKRERIILDPGMGFFLGSNPETSILVLKRFPEIQEAFNLQVMIAVSRKSFLGKITGTDVKSRLAPTLAAEMYAYKKGADYLRTHDVKSLSDALKISKALG", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Pterin-binding_dom, DHP_synth_dom, DHP_synth_dom, Pterin-binding_dom, Pterin-binding_dom, Pterin-binding_dom that are essential for its biological function; 2. The protein should belong to DHP_synth-like that shares evolutionary origin and functional similarity; 3. The protein should be classified within Dihydropteroate_synth-like_sf, Dihydropteroate_synth-like_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MSKIFGIVNITTDSFSDGGLYLDTDKAIEHALHLVEDGADVIDLGAASSNPDTTEVGVVEEIKRLKPVIKALKEKGISISVDTFKPEVQSFCIEQKVDFINDIQGFPYPEIYSGLAKSDCKLVLMHSVQRIGAATKVETNPEEVFTSMMEFFKERIAALVEAGVKRERIILDPGMGFFLGSNPETSILVLKRFPEIQEAFNLQVMIAVSRKSFLGKITGTDVKSRLAPTLAAEMYAYKKGADYLRTHDVKSLSDALKISKALG" }, { "InterPro": [ { "InterPro-ID": "IPR000453", "InterPro-Name": "Chorismate_synth", "InterPro-Type": "FAMILY", "Beg": 1, "End": 526 }, { "InterPro-ID": "IPR000453", "InterPro-Name": "Chorismate_synth", "InterPro-Type": "FAMILY", "Beg": 8, "End": 360 }, { "InterPro-ID": "IPR000453", "InterPro-Name": "Chorismate_synth", "InterPro-Type": "FAMILY", "Beg": 424, "End": 509 }, { "InterPro-ID": "IPR000453", "InterPro-Name": "Chorismate_synth", "InterPro-Type": "FAMILY", "Beg": 8, "End": 507 }, { "InterPro-ID": "IPR035904", "InterPro-Name": "Chorismate_synth_AroC_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 230, "End": 520 }, { "InterPro-ID": "IPR035904", "InterPro-Name": "Chorismate_synth_AroC_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1, "End": 172 }, { "InterPro-ID": "IPR000453", "InterPro-Name": "Chorismate_synth", "InterPro-Type": "FAMILY", "Beg": 8, "End": 516 }, { "InterPro-ID": "IPR035904", "InterPro-Name": "Chorismate_synth_AroC_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 226, "End": 374 }, { "InterPro-ID": "IPR035904", "InterPro-Name": "Chorismate_synth_AroC_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 412, "End": 523 }, { "InterPro-ID": "IPR035904", "InterPro-Name": "Chorismate_synth_AroC_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1, "End": 196 } ], "response#1": "MSTYGTLLKVTSYGESHGKAIGCVIDGFLSNIEINFDLIQKQLDRRRPNQSKLTSNRNEKDKLVILSGFDENKTLGTPITFLIYNEDIKKEDYNSFINIPRPGHGDYTYFMKYHVKNKSGSSRFSGRETATRVAAGACIEQWLYKSYNCSIVSYVHSVGNIKIPEQVSKELENKNPPSRDLVDSYGTVRYNEKEKIFMDCFNRIYDMNASMLKTDEYNKNTLTIPSIDNTYINVKTNECNINQVDNNHNNYINDKDNTFNNSEKSDEWIYLQTRCPHPYTAVQICSYILKLKNKGDSVGGIATCIIQNPPIGIGEPIFDKLEAELAKMILSIPAVKGIEFGSGFNGTYMFGSMHNDIFIPVENMSTKKESDLLYDDKGECKNMSYHSTIQNNEDQILNSTKGFMPPKNDKNFNNIDDYNVTFNNNEEKLLITKTNNCGGILAGISTGNNIVFRSAIKPVSSIQIEKETSDFYGNMCNLKVQGRHDSCILPRLPPIIEASSSMVIGDLILRQISKYGDKKLPTLFRNM", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Chorismate_synth, Chorismate_synth, Chorismate_synth, Chorismate_synth, Chorismate_synth that shares evolutionary origin and functional similarity; 2. The protein should be classified within Chorismate_synth_AroC_sf, Chorismate_synth_AroC_sf, Chorismate_synth_AroC_sf, Chorismate_synth_AroC_sf, Chorismate_synth_AroC_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MSTYGTLLKVTSYGESHGKAIGCVIDGFLSNIEINFDLIQKQLDRRRPNQSKLTSNRNEKDKLVILSGFDENKTLGTPITFLIYNEDIKKEDYNSFINIPRPGHGDYTYFMKYHVKNKSGSSRFSGRETATRVAAGACIEQWLYKSYNCSIVSYVHSVGNIKIPEQVSKELENKNPPSRDLVDSYGTVRYNEKEKIFMDCFNRIYDMNASMLKTDEYNKNTLTIPSIDNTYINVKTNECNINQVDNNHNNYINDKDNTFNNSEKSDEWIYLQTRCPHPYTAVQICSYILKLKNKGDSVGGIATCIIQNPPIGIGEPIFDKLEAELAKMILSIPAVKGIEFGSGFNGTYMFGSMHNDIFIPVENMSTKKESDLLYDDKGECKNMSYHSTIQNNEDQILNSTKGFMPPKNDKNFNNIDDYNVTFNNNEEKLLITKTNNCGGILAGISTGNNIVFRSAIKPVSSIQIEKETSDFYGNMCNLKVQGRHDSCILPRLPPIIEASSSMVIGDLILRQISKYGDKKLPTLFRNM" }, { "InterPro": [ { "InterPro-ID": "IPR038338", "InterPro-Name": "PriB/PriC_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 2, "End": 99 }, { "InterPro-ID": "IPR010890", "InterPro-Name": "Primosomal_replicat_PriB/PriC", "InterPro-Type": "FAMILY", "Beg": 9, "End": 174 } ], "response#1": "MVKTAQLLQTLNDQLSELAALVAPLAEHATLSPRFDRQLFHTRSTLMQAYLAEAQHNFNQLRQAVERQQLPQVVWIAERLAAQIAALRRETATWSLRSWDHASPTLSRWQRRRLQHQEYERRLLAMRDQRQRQLAQATSLDEQQRLGKEVEAYSGRLARCRQALDKIENVLARLTR", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Primosomal_replicat_PriB/PriC that shares evolutionary origin and functional similarity; 2. The protein should be classified within PriB/PriC_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MVKTAQLLQTLNDQLSELAALVAPLAEHATLSPRFDRQLFHTRSTLMQAYLAEAQHNFNQLRQAVERQQLPQVVWIAERLAAQIAALRRETATWSLRSWDHASPTLSRWQRRRLQHQEYERRLLAMRDQRQRQLAQATSLDEQQRLGKEVEAYSGRLARCRQALDKIENVLARLTR" }, { "InterPro": [ { "InterPro-ID": "IPR036055", "InterPro-Name": "LDL_receptor-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 89, "End": 123 }, { "InterPro-ID": "IPR020864", "InterPro-Name": "MACPF", "InterPro-Type": "DOMAIN", "Beg": 248, "End": 450 }, { "InterPro-ID": "IPR036383", "InterPro-Name": "TSP1_rpt_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 26, "End": 73 }, { "InterPro-ID": "IPR036055", "InterPro-Name": "LDL_receptor-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 78, "End": 119 }, { "InterPro-ID": "IPR036383", "InterPro-Name": "TSP1_rpt_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 499, "End": 545 }, { "InterPro-ID": "IPR000884", "InterPro-Name": "TSP1_rpt", "InterPro-Type": "REPEAT", "Beg": 500, "End": 549 }, { "InterPro-ID": "IPR020864", "InterPro-Name": "MACPF", "InterPro-Type": "DOMAIN", "Beg": 122, "End": 456 }, { "InterPro-ID": "IPR048827", "InterPro-Name": "C7_FIM2_N", "InterPro-Type": "DOMAIN", "Beg": 769, "End": 791 }, { "InterPro-ID": "IPR048825", "InterPro-Name": "C7_KAZAL", "InterPro-Type": "DOMAIN", "Beg": 706, "End": 758 }, { "InterPro-ID": "IPR035976", "InterPro-Name": "Sushi/SCR/CCP_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 570, "End": 634 }, { "InterPro-ID": "IPR000884", "InterPro-Name": "TSP1_rpt", "InterPro-Type": "REPEAT", "Beg": 30, "End": 80 }, { "InterPro-ID": "IPR000884", "InterPro-Name": "TSP1_rpt", "InterPro-Type": "REPEAT", "Beg": 503, "End": 551 }, { "InterPro-ID": "IPR000884", "InterPro-Name": "TSP1_rpt", "InterPro-Type": "REPEAT", "Beg": 34, "End": 79 }, { "InterPro-ID": "IPR000884", "InterPro-Name": "TSP1_rpt", "InterPro-Type": "REPEAT", "Beg": 506, "End": 548 }, { "InterPro-ID": "IPR000436", "InterPro-Name": "Sushi_SCR_CCP_dom", "InterPro-Type": "DOMAIN", "Beg": 632, "End": 682 }, { "InterPro-ID": "IPR000436", "InterPro-Name": "Sushi_SCR_CCP_dom", "InterPro-Type": "DOMAIN", "Beg": 571, "End": 626 }, { "InterPro-ID": "IPR020863", "InterPro-Name": "MACPF_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 291, "End": 302 }, { "InterPro-ID": "IPR003884", "InterPro-Name": "FacI_MAC", "InterPro-Type": "DOMAIN", "Beg": 773, "End": 841 }, { "InterPro-ID": "IPR003884", "InterPro-Name": "FacI_MAC", "InterPro-Type": "DOMAIN", "Beg": 699, "End": 766 }, { "InterPro-ID": "IPR000436", "InterPro-Name": "Sushi_SCR_CCP_dom", "InterPro-Type": "DOMAIN", "Beg": 569, "End": 628 }, { "InterPro-ID": "IPR002172", "InterPro-Name": "LDrepeatLR_classA_rpt", "InterPro-Type": "REPEAT", "Beg": 85, "End": 119 }, { "InterPro-ID": "IPR001862", "InterPro-Name": "MAC_perforin", "InterPro-Type": "FAMILY", "Beg": 457, "End": 477 }, { "InterPro-ID": "IPR001862", "InterPro-Name": "MAC_perforin", "InterPro-Type": "FAMILY", "Beg": 405, "End": 424 }, { "InterPro-ID": "IPR001862", "InterPro-Name": "MAC_perforin", "InterPro-Type": "FAMILY", "Beg": 434, "End": 453 }, { "InterPro-ID": "IPR001862", "InterPro-Name": "MAC_perforin", "InterPro-Type": "FAMILY", "Beg": 280, "End": 302 }, { "InterPro-ID": "IPR001862", "InterPro-Name": "MAC_perforin", "InterPro-Type": "FAMILY", "Beg": 89, "End": 109 }, { "InterPro-ID": "IPR001862", "InterPro-Name": "MAC_perforin", "InterPro-Type": "FAMILY", "Beg": 47, "End": 63 }, { "InterPro-ID": "IPR036383", "InterPro-Name": "TSP1_rpt_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 499, "End": 549 }, { "InterPro-ID": "IPR036383", "InterPro-Name": "TSP1_rpt_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 25, "End": 79 }, { "InterPro-ID": "IPR002172", "InterPro-Name": "LDrepeatLR_classA_rpt", "InterPro-Type": "REPEAT", "Beg": 87, "End": 119 }, { "InterPro-ID": "IPR035976", "InterPro-Name": "Sushi/SCR/CCP_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 626, "End": 682 }, { "InterPro-ID": "IPR000436", "InterPro-Name": "Sushi_SCR_CCP_dom", "InterPro-Type": "DOMAIN", "Beg": 631, "End": 689 }, { "InterPro-ID": "IPR000884", "InterPro-Name": "TSP1_rpt", "InterPro-Type": "REPEAT", "Beg": 27, "End": 80 }, { "InterPro-ID": "IPR000436", "InterPro-Name": "Sushi_SCR_CCP_dom", "InterPro-Type": "DOMAIN", "Beg": 631, "End": 688 }, { "InterPro-ID": "IPR000436", "InterPro-Name": "Sushi_SCR_CCP_dom", "InterPro-Type": "DOMAIN", "Beg": 629, "End": 690 }, { "InterPro-ID": "IPR020864", "InterPro-Name": "MACPF", "InterPro-Type": "DOMAIN", "Beg": 241, "End": 448 }, { "InterPro-ID": "IPR002172", "InterPro-Name": "LDrepeatLR_classA_rpt", "InterPro-Type": "REPEAT", "Beg": 84, "End": 121 }, { "InterPro-ID": "IPR040729", "InterPro-Name": "Kazal_3", "InterPro-Type": "DOMAIN", "Beg": 792, "End": 839 }, { "InterPro-ID": "IPR000436", "InterPro-Name": "Sushi_SCR_CCP_dom", "InterPro-Type": "DOMAIN", "Beg": 571, "End": 627 }, { "InterPro-ID": "IPR023415", "InterPro-Name": "LDLR_class-A_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 96, "End": 119 }, { "InterPro-ID": "IPR002172", "InterPro-Name": "LDrepeatLR_classA_rpt", "InterPro-Type": "REPEAT", "Beg": 84, "End": 120 } ], "response#1": "MQVTSLLILVCFIAAFQVFSRASSPVNCKWDSYGPWSECNGCTKTQTRRRSVAVYGQYGGYPCEGSAFETQSCKPERGCPTEEGCGDRFRCFSGQCISKSLVCNGDPDCEEDGADEDKCENVANPSCNIDKPPPNIELTGYGYNVVTGQGKKRVINTKSFGGQCRKVFSGDGKDFYRLSGNILSYTFQVKVDNDFNYEFYNSSWSYIKHTSTEQNTFYSWKGLFSHSRNTYGHGSAKEEIDTKMKSYKLLVVQNTVEVAQFTNNNPEFLQVAEPFWKELSHLPTLYDYSAYRRLIDQYGTHYLQSGSLGGEYRVLFYVDSGSAKETGFQSDQDNACSSADFQFLFTSSADQRCMKQLETEKSTSGNKGRLLRGKPLVRGGDSGFVADLSFLDLDNPAGNKQRYSSWAGSVTRLPQVIKEKLAPLYELVKEVPCASVKRLYLKRAIEEYFDEFDPCHCRPCQNGGLAIVVETQCQCLCKPYTFGSACEQGVLVGDQAGGVDGGWNCWSSWSPCVQGKRTRSRECNNPPPRDDGKSCLGETTESKQCEDQDLEKLRLLEPHCFHSSLAPKEFCLSPPALKDGFVQGEGTMVPVGQSVVYACDEGYSLIGDPVARCGEDLQWLVGEMHCQKLACVLPGEMNGMQSHPQKPFYMVGEKVTLSCVGGMSLEGPSTLLCGSSLKWSPELKDAKCVQKATSTPPPAAPACQPWEKLQNSKCICKMPYECGSSLDVCARDESRNKILSLTICKMHVVHCHKRNYTLVGKESCTLPSPAEKVCGACPIWSKCDAQNGKCICREASECQTAGYRICVEVNGKEETMSECEAGILRCRGQSISITAIKPCAEEAAQ", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more MACPF, MACPF, C7_FIM2_N, C7_KAZAL, Sushi_SCR_CCP_dom, Sushi_SCR_CCP_dom, FacI_MAC, FacI_MAC, Sushi_SCR_CCP_dom, Sushi_SCR_CCP_dom, Sushi_SCR_CCP_dom, Sushi_SCR_CCP_dom, MACPF, Kazal_3, Sushi_SCR_CCP_dom that are essential for its biological function; 2. The protein should belong to MAC_perforin, MAC_perforin, MAC_perforin, MAC_perforin, MAC_perforin, MAC_perforin that shares evolutionary origin and functional similarity; 3. The protein should be classified within LDL_receptor-like_sf, TSP1_rpt_sf, LDL_receptor-like_sf, TSP1_rpt_sf, Sushi/SCR/CCP_sf, TSP1_rpt_sf, TSP1_rpt_sf, Sushi/SCR/CCP_sf sharing conserved structural features; 4. The protein should include one or more TSP1_rpt, TSP1_rpt, TSP1_rpt, TSP1_rpt, TSP1_rpt, LDrepeatLR_classA_rpt, LDrepeatLR_classA_rpt, TSP1_rpt, LDrepeatLR_classA_rpt, LDrepeatLR_classA_rpt that provide structural or functional support; 5. The protein should contain MACPF_CS, LDLR_class-A_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MQVTSLLILVCFIAAFQVFSRASSPVNCKWDSYGPWSECNGCTKTQTRRRSVAVYGQYGGYPCEGSAFETQSCKPERGCPTEEGCGDRFRCFSGQCISKSLVCNGDPDCEEDGADEDKCENVANPSCNIDKPPPNIELTGYGYNVVTGQGKKRVINTKSFGGQCRKVFSGDGKDFYRLSGNILSYTFQVKVDNDFNYEFYNSSWSYIKHTSTEQNTFYSWKGLFSHSRNTYGHGSAKEEIDTKMKSYKLLVVQNTVEVAQFTNNNPEFLQVAEPFWKELSHLPTLYDYSAYRRLIDQYGTHYLQSGSLGGEYRVLFYVDSGSAKETGFQSDQDNACSSADFQFLFTSSADQRCMKQLETEKSTSGNKGRLLRGKPLVRGGDSGFVADLSFLDLDNPAGNKQRYSSWAGSVTRLPQVIKEKLAPLYELVKEVPCASVKRLYLKRAIEEYFDEFDPCHCRPCQNGGLAIVVETQCQCLCKPYTFGSACEQGVLVGDQAGGVDGGWNCWSSWSPCVQGKRTRSRECNNPPPRDDGKSCLGETTESKQCEDQDLEKLRLLEPHCFHSSLAPKEFCLSPPALKDGFVQGEGTMVPVGQSVVYACDEGYSLIGDPVARCGEDLQWLVGEMHCQKLACVLPGEMNGMQSHPQKPFYMVGEKVTLSCVGGMSLEGPSTLLCGSSLKWSPELKDAKCVQKATSTPPPAAPACQPWEKLQNSKCICKMPYECGSSLDVCARDESRNKILSLTICKMHVVHCHKRNYTLVGKESCTLPSPAEKVCGACPIWSKCDAQNGKCICREASECQTAGYRICVEVNGKEETMSECEAGILRCRGQSISITAIKPCAEEAAQ" }, { "InterPro": [ { "InterPro-ID": "IPR036686", "InterPro-Name": "Hydrophobin_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 22, "End": 96 }, { "InterPro-ID": "IPR010636", "InterPro-Name": "Cerato-ulmin_hydrophobin", "InterPro-Type": "FAMILY", "Beg": 8, "End": 93 }, { "InterPro-ID": "IPR036686", "InterPro-Name": "Hydrophobin_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 28, "End": 95 }, { "InterPro-ID": "IPR010636", "InterPro-Name": "Cerato-ulmin_hydrophobin", "InterPro-Type": "FAMILY", "Beg": 28, "End": 91 }, { "InterPro-ID": "IPR010636", "InterPro-Name": "Cerato-ulmin_hydrophobin", "InterPro-Type": "FAMILY", "Beg": 29, "End": 92 } ], "response#1": "MKFFTAAALFAAVAIAGPVEVRTGGGSICPDGLFSNPQCCDTQLLGIIGLGCEVPSQTPRDGADFKNICAKTGDQALCCVLPIAGQDLLCQAAVGAA", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Cerato-ulmin_hydrophobin, Cerato-ulmin_hydrophobin, Cerato-ulmin_hydrophobin that shares evolutionary origin and functional similarity; 2. The protein should be classified within Hydrophobin_sf, Hydrophobin_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MKFFTAAALFAAVAIAGPVEVRTGGGSICPDGLFSNPQCCDTQLLGIIGLGCEVPSQTPRDGADFKNICAKTGDQALCCVLPIAGQDLLCQAAVGAA" }, { "InterPro": [ { "InterPro-ID": "IPR010636", "InterPro-Name": "Cerato-ulmin_hydrophobin", "InterPro-Type": "FAMILY", "Beg": 16, "End": 84 }, { "InterPro-ID": "IPR036686", "InterPro-Name": "Hydrophobin_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 18, "End": 87 }, { "InterPro-ID": "IPR010636", "InterPro-Name": "Cerato-ulmin_hydrophobin", "InterPro-Type": "FAMILY", "Beg": 18, "End": 81 }, { "InterPro-ID": "IPR036686", "InterPro-Name": "Hydrophobin_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 15, "End": 87 }, { "InterPro-ID": "IPR010636", "InterPro-Name": "Cerato-ulmin_hydrophobin", "InterPro-Type": "FAMILY", "Beg": 19, "End": 84 } ], "response#1": "MKFFIATIFATGALAISVCPTGLYSNPQCCGANILGVAALDCHTPRAPILPGALFEAVCSDEGGKEPLCCTIPVAGQDLLCVAPVGTA", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Cerato-ulmin_hydrophobin, Cerato-ulmin_hydrophobin, Cerato-ulmin_hydrophobin that shares evolutionary origin and functional similarity; 2. The protein should be classified within Hydrophobin_sf, Hydrophobin_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MKFFIATIFATGALAISVCPTGLYSNPQCCGANILGVAALDCHTPRAPILPGALFEAVCSDEGGKEPLCCTIPVAGQDLLCVAPVGTA" }, { "InterPro": [ { "InterPro-ID": "IPR038338", "InterPro-Name": "PriB/PriC_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1, "End": 98 }, { "InterPro-ID": "IPR010890", "InterPro-Name": "Primosomal_replicat_PriB/PriC", "InterPro-Type": "FAMILY", "Beg": 9, "End": 169 } ], "response#1": "MRTPLLLQSLKTRVAALHTLIGPLASQRHFSPRFDRQLFACRGARLGDYLTEAEESLTHLEAAVNQGDATRVAWLAERLAAQIEALQREAATATLRRHENAHLPGGRLHARLAEYQEYERRLLAMKNEREQRYAERHDPQLAREITALDERLTRCRTAIARTERALERITR", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Primosomal_replicat_PriB/PriC that shares evolutionary origin and functional similarity; 2. The protein should be classified within PriB/PriC_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MRTPLLLQSLKTRVAALHTLIGPLASQRHFSPRFDRQLFACRGARLGDYLTEAEESLTHLEAAVNQGDATRVAWLAERLAAQIEALQREAATATLRRHENAHLPGGRLHARLAEYQEYERRLLAMKNEREQRYAERHDPQLAREITALDERLTRCRTAIARTERALERITR" }, { "InterPro": [ { "InterPro-ID": "IPR001415", "InterPro-Name": "PTH/PTH-rel", "InterPro-Type": "FAMILY", "Beg": 30, "End": 65 }, { "InterPro-ID": "IPR003625", "InterPro-Name": "PTH", "InterPro-Type": "FAMILY", "Beg": 1, "End": 115 }, { "InterPro-ID": "IPR001415", "InterPro-Name": "PTH/PTH-rel", "InterPro-Type": "FAMILY", "Beg": 33, "End": 43 } ], "response#1": "MMSANTVAKVMIIMLAVCLLTQTDGKPVRKRAVSEIQLMHNLGKHLASMERMQWLRRKLQDMHNFVSLGVQMAARDGSHQKPTKKEENVLVDGNPKSLGEGDKADVDVLVKSKSQ", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to PTH/PTH-rel, PTH, PTH/PTH-rel that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MMSANTVAKVMIIMLAVCLLTQTDGKPVRKRAVSEIQLMHNLGKHLASMERMQWLRRKLQDMHNFVSLGVQMAARDGSHQKPTKKEENVLVDGNPKSLGEGDKADVDVLVKSKSQ" }, { "InterPro": [ { "InterPro-ID": "IPR046350", "InterPro-Name": "Cystatin_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 22, "End": 128 }, { "InterPro-ID": "IPR000010", "InterPro-Name": "Cystatin_dom", "InterPro-Type": "DOMAIN", "Beg": 20, "End": 128 }, { "InterPro-ID": "IPR000010", "InterPro-Name": "Cystatin_dom", "InterPro-Type": "DOMAIN", "Beg": 33, "End": 127 }, { "InterPro-ID": "IPR000010", "InterPro-Name": "Cystatin_dom", "InterPro-Type": "DOMAIN", "Beg": 32, "End": 116 } ], "response#1": "MSIVKAALLVVLGVVCVSSAFPGVWRKHHPDVDPRYKEWAHFAISSQVENRTNFDTLMTLISVESQVIAGVDYKLKMKVAESTCVIGVDSYSKERCYLKVNVPYMLCTAVVNYMPWEHKTILKSYDCSDRVYGVKSAE", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Cystatin_dom, Cystatin_dom, Cystatin_dom that are essential for its biological function; 2. The protein should be classified within Cystatin_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MSIVKAALLVVLGVVCVSSAFPGVWRKHHPDVDPRYKEWAHFAISSQVENRTNFDTLMTLISVESQVIAGVDYKLKMKVAESTCVIGVDSYSKERCYLKVNVPYMLCTAVVNYMPWEHKTILKSYDCSDRVYGVKSAE" }, { "InterPro": [ { "InterPro-ID": "IPR001810", "InterPro-Name": "F-box_dom", "InterPro-Type": "DOMAIN", "Beg": 8, "End": 47 }, { "InterPro-ID": "IPR053222", "InterPro-Name": "Zygotic_Embryogenesis-Asso", "InterPro-Type": "FAMILY", "Beg": 1, "End": 299 }, { "InterPro-ID": "IPR012885", "InterPro-Name": "F-box-assoc_dom_typ2", "InterPro-Type": "DOMAIN", "Beg": 179, "End": 239 } ], "response#1": "MATVPFPILCLPDFVLQKSLKLMGVVEHLCLSILSKNIKQLIATLKGYPKCFSFKFVPFTSLTVVGERFKHFSFRFDIDESSQNANLRSYTDEGTYITLTVPGFTVKHWIEHVAYVLCRNNSIKLVLWEPNIDEVYEIVKDMRTVEVVIVSSEIQSCHLLKLFPSLRYLGVYKAPISAQILTYNLLHLEVKTKVTLNDILISNCSNFSISGNDVSDKELNFFMRSWIKGSNPRLTKFYIRNSLRVRDPYLETVLFQNIDYIETHKKIYWRTFEISRPDGTKADVMWDPLYNSYFNMTVQH", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more F-box_dom, F-box-assoc_dom_typ2 that are essential for its biological function; 2. The protein should belong to Zygotic_Embryogenesis-Asso that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MATVPFPILCLPDFVLQKSLKLMGVVEHLCLSILSKNIKQLIATLKGYPKCFSFKFVPFTSLTVVGERFKHFSFRFDIDESSQNANLRSYTDEGTYITLTVPGFTVKHWIEHVAYVLCRNNSIKLVLWEPNIDEVYEIVKDMRTVEVVIVSSEIQSCHLLKLFPSLRYLGVYKAPISAQILTYNLLHLEVKTKVTLNDILISNCSNFSISGNDVSDKELNFFMRSWIKGSNPRLTKFYIRNSLRVRDPYLETVLFQNIDYIETHKKIYWRTFEISRPDGTKADVMWDPLYNSYFNMTVQH" }, { "InterPro": [ { "InterPro-ID": "IPR008767", "InterPro-Name": "Phage_SPP1_head-tail_adaptor", "InterPro-Type": "FAMILY", "Beg": 6, "End": 108 }, { "InterPro-ID": "IPR008767", "InterPro-Name": "Phage_SPP1_head-tail_adaptor", "InterPro-Type": "FAMILY", "Beg": 1, "End": 108 }, { "InterPro-ID": "IPR038666", "InterPro-Name": "SSP1_head-tail_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1, "End": 112 } ], "response#1": "MEPGRFRNRVKILTFTTSRDPSGQPVESWTGGNPVPAEVKGISGREQLSGGAETAQATIRVWMRFRSELNASSRLEVLSGPYKGQVLNIIGPPVANATGTRLEILCKTGAEK", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Phage_SPP1_head-tail_adaptor, Phage_SPP1_head-tail_adaptor that shares evolutionary origin and functional similarity; 2. The protein should be classified within SSP1_head-tail_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MEPGRFRNRVKILTFTTSRDPSGQPVESWTGGNPVPAEVKGISGREQLSGGAETAQATIRVWMRFRSELNASSRLEVLSGPYKGQVLNIIGPPVANATGTRLEILCKTGAEK" }, { "InterPro": [ { "InterPro-ID": "IPR006450", "InterPro-Name": "Phage_HK97_gp6-like", "InterPro-Type": "FAMILY", "Beg": 11, "End": 92 }, { "InterPro-ID": "IPR047186", "InterPro-Name": "Gp6_gp15-like", "InterPro-Type": "FAMILY", "Beg": 12, "End": 96 }, { "InterPro-ID": "IPR021146", "InterPro-Name": "Phage_gp6-like_head-tail", "InterPro-Type": "FAMILY", "Beg": 9, "End": 81 } ], "response#1": "MAIDVLDVISLSLFKQQIEFEEDDRDELITLYAQAAFDYCMRWCDEPAWKVAADIPAAVKGAVLLVFADMFEHRTAQSEVQLYENAAAERMMFIHRNWRGKAESEEGS", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Phage_HK97_gp6-like, Gp6_gp15-like, Phage_gp6-like_head-tail that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MAIDVLDVISLSLFKQQIEFEEDDRDELITLYAQAAFDYCMRWCDEPAWKVAADIPAAVKGAVLLVFADMFEHRTAQSEVQLYENAAAERMMFIHRNWRGKAESEEGS" }, { "InterPro": [ { "InterPro-ID": "IPR031891", "InterPro-Name": "DMP12", "InterPro-Type": "FAMILY", "Beg": 5, "End": 118 }, { "InterPro-ID": "IPR038223", "InterPro-Name": "DMP12_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1, "End": 118 }, { "InterPro-ID": "IPR031891", "InterPro-Name": "DMP12", "InterPro-Type": "FAMILY", "Beg": 4, "End": 118 } ], "response#1": "MNEHNLLIFCLKDNVSISEYTEMIDWAYKNIQSETVVEITENQIIEYQNRGLWRLVSEITDNWLFGPSEGDWLIDKESILAVKEKLQNSDFSTEPLVKNIIHVLEYAIKNEKTVIFHF", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to DMP12, DMP12 that shares evolutionary origin and functional similarity; 2. The protein should be classified within DMP12_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MNEHNLLIFCLKDNVSISEYTEMIDWAYKNIQSETVVEITENQIIEYQNRGLWRLVSEITDNWLFGPSEGDWLIDKESILAVKEKLQNSDFSTEPLVKNIIHVLEYAIKNEKTVIFHF" }, { "InterPro": [ { "InterPro-ID": "IPR011545", "InterPro-Name": "DEAD/DEAH_box_helicase_dom", "InterPro-Type": "DOMAIN", "Beg": 28, "End": 210 }, { "InterPro-ID": "IPR055369", "InterPro-Name": "WH2_Lhr", "InterPro-Type": "DOMAIN", "Beg": 891, "End": 995 }, { "InterPro-ID": "IPR003593", "InterPro-Name": "AAA+_ATPase", "InterPro-Type": "DOMAIN", "Beg": 40, "End": 383 }, { "InterPro-ID": "IPR001650", "InterPro-Name": "Helicase_C-like", "InterPro-Type": "DOMAIN", "Beg": 279, "End": 396 }, { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 7, "End": 228 }, { "InterPro-ID": "IPR055368", "InterPro-Name": "WH3_Lhr", "InterPro-Type": "DOMAIN", "Beg": 1082, "End": 1174 }, { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 256, "End": 414 }, { "InterPro-ID": "IPR014001", "InterPro-Name": "Helicase_ATP-bd", "InterPro-Type": "DOMAIN", "Beg": 35, "End": 226 }, { "InterPro-ID": "IPR001650", "InterPro-Name": "Helicase_C-like", "InterPro-Type": "DOMAIN", "Beg": 332, "End": 396 }, { "InterPro-ID": "IPR052511", "InterPro-Name": "ATP-dep_Helicase", "InterPro-Type": "FAMILY", "Beg": 12, "End": 927 }, { "InterPro-ID": "IPR055367", "InterPro-Name": "WH4_Lhr", "InterPro-Type": "DOMAIN", "Beg": 1294, "End": 1375 }, { "InterPro-ID": "IPR014001", "InterPro-Name": "Helicase_ATP-bd", "InterPro-Type": "DOMAIN", "Beg": 23, "End": 241 }, { "InterPro-ID": "IPR001650", "InterPro-Name": "Helicase_C-like", "InterPro-Type": "DOMAIN", "Beg": 257, "End": 451 }, { "InterPro-ID": "IPR013701", "InterPro-Name": "DEAD/DEAH_assoc", "InterPro-Type": "DOMAIN", "Beg": 658, "End": 846 }, { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 37, "End": 400 }, { "InterPro-ID": "IPR045628", "InterPro-Name": "Lhr_WH_dom", "InterPro-Type": "DOMAIN", "Beg": 423, "End": 593 } ], "response#1": "MTTNGADPLGRFSALTREWFTTAFAAPTPAQADAWSAISEGNNTLVIAPTGSGKTLAAFLWAIDRLADPAREPSQGTQVLYVSPLKALAVDVERNLRTPLTGITRVAERHGLPAPSITVGVRSGDTPPNQRRAMIANPPDVLITTPESLFLMLTSAARETLTSVRTVIVDEVHAVAATKRGAHLALSLERLDQLLDTPAQRIGLSATVRPPEEVARFLSGQAPTTIVCPPAAKTFDLSVQVPVPDMANLDNNSIWPDVEERIVDLVEAHNSSIVFANSRRLAERLTSRLNEIHAERSGIELPAGPNPEVGGGAPAHLMGSGQANGAPPLLARAHHGSVSKEQRAQVEDDLKSGRLRAVVATSSLELGIDMGAVDLVIQVEAPPSVASGLQRVGRAGHQVGEISQGVLFPKHRTDLIGCAVTVQRMQTGDIETLRVPANPLDVLAQHTVAVAALEPVDADAWFDAVRRSAPFATLPRSAFEATLDLLSGKYPSTEFAELRPRLVYDRDTGTLTARPGAQRLAVTSGGAIPDRGMFTVYLASETEKPSRVGELDEEMVYESRPGDVISLGATSWRITEITHDRVLVIPAPGQPARLPFWRGDSVGRPAELGAAVGAFTGELASLDRKAFDKRCQKMGFAGYATDNLHQLLREQREATGVVPSDTTFVVERFRDELGDWRVILHSPYGLRVHGPLALAVGRRLRERYGIDEKPTASDDGIIVRLPDSGDTPPGADLFVFDADEIEPIVTAEVGGSALFASRFRECAARALLLPRRHPGKRSPLWHQRQRAAQLLDIARKYPDFPIVLEAVRECLQDVYDVPALIELMHKIAQRRLRIVEVETATPSPFAASLLFGYVGAFMYEGDSPLAERRAAALALDTVLLSELLGRVELRELLDPAVVASTSAQLQHLTPERAARDAEGVADLLRLLGPLTEADIAQRCTADNIGAWLDGLHAAKRALPVTYAGQTWWAAVEDIGLLRDGIGVPVPVGVPAAFTESASDPLGDLIGRYARTRGPFTTEQTAARFGLGVRVASDVLSRMAVDGRLIRGEFAADLSGEQWCDAQVLKILRRRSLAALRAQVEPVSTDAYARFLPSWQHVGSTNTTGIDGLATVIEQLAGVPIPASAVESLVFPQRVRDYQPAMLDELLASGEVMWSGAGQIGNGDGWVAFHLADTAPLTLTHGAEIEFTDTHRVILETLGHGGAYFFRQLTDGTVEGTAGQELKQALWELIWAGWVTGDTFAPVRAVLSGPRRSGAPAHRQRQRPPRLSRYSVAHAQTRGTDPTVSGRWSALPAAEPDSTVRAHFQAELLLGRHGVLTKGAVGAEGVPGGFATLYKVLSTFEDAGRCQRGYFVESLGGAQFAVASTVDRLRSYLDNVDPERPEYHAVVLAATDPANPYGAALGWPTDSEAHRPGRKAGALVALVDGRLVWFLERGGRSLLSFGADADAQRAAAGALTDLVSAGRIPSLLVERINGVAVLDPDVDAERAVVQDALLGAGLSRTPRGLRLR", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more DEAD/DEAH_box_helicase_dom, WH2_Lhr, AAA+_ATPase, Helicase_C-like, WH3_Lhr, Helicase_ATP-bd, Helicase_C-like, WH4_Lhr, Helicase_ATP-bd, Helicase_C-like, DEAD/DEAH_assoc, Lhr_WH_dom that are essential for its biological function; 2. The protein should belong to ATP-dep_Helicase that shares evolutionary origin and functional similarity; 3. The protein should be classified within P-loop_NTPase, P-loop_NTPase, P-loop_NTPase sharing conserved structural features. The designed protein sequence is ", "reference": "MTTNGADPLGRFSALTREWFTTAFAAPTPAQADAWSAISEGNNTLVIAPTGSGKTLAAFLWAIDRLADPAREPSQGTQVLYVSPLKALAVDVERNLRTPLTGITRVAERHGLPAPSITVGVRSGDTPPNQRRAMIANPPDVLITTPESLFLMLTSAARETLTSVRTVIVDEVHAVAATKRGAHLALSLERLDQLLDTPAQRIGLSATVRPPEEVARFLSGQAPTTIVCPPAAKTFDLSVQVPVPDMANLDNNSIWPDVEERIVDLVEAHNSSIVFANSRRLAERLTSRLNEIHAERSGIELPAGPNPEVGGGAPAHLMGSGQANGAPPLLARAHHGSVSKEQRAQVEDDLKSGRLRAVVATSSLELGIDMGAVDLVIQVEAPPSVASGLQRVGRAGHQVGEISQGVLFPKHRTDLIGCAVTVQRMQTGDIETLRVPANPLDVLAQHTVAVAALEPVDADAWFDAVRRSAPFATLPRSAFEATLDLLSGKYPSTEFAELRPRLVYDRDTGTLTARPGAQRLAVTSGGAIPDRGMFTVYLASETEKPSRVGELDEEMVYESRPGDVISLGATSWRITEITHDRVLVIPAPGQPARLPFWRGDSVGRPAELGAAVGAFTGELASLDRKAFDKRCQKMGFAGYATDNLHQLLREQREATGVVPSDTTFVVERFRDELGDWRVILHSPYGLRVHGPLALAVGRRLRERYGIDEKPTASDDGIIVRLPDSGDTPPGADLFVFDADEIEPIVTAEVGGSALFASRFRECAARALLLPRRHPGKRSPLWHQRQRAAQLLDIARKYPDFPIVLEAVRECLQDVYDVPALIELMHKIAQRRLRIVEVETATPSPFAASLLFGYVGAFMYEGDSPLAERRAAALALDTVLLSELLGRVELRELLDPAVVASTSAQLQHLTPERAARDAEGVADLLRLLGPLTEADIAQRCTADNIGAWLDGLHAAKRALPVTYAGQTWWAAVEDIGLLRDGIGVPVPVGVPAAFTESASDPLGDLIGRYARTRGPFTTEQTAARFGLGVRVASDVLSRMAVDGRLIRGEFAADLSGEQWCDAQVLKILRRRSLAALRAQVEPVSTDAYARFLPSWQHVGSTNTTGIDGLATVIEQLAGVPIPASAVESLVFPQRVRDYQPAMLDELLASGEVMWSGAGQIGNGDGWVAFHLADTAPLTLTHGAEIEFTDTHRVILETLGHGGAYFFRQLTDGTVEGTAGQELKQALWELIWAGWVTGDTFAPVRAVLSGPRRSGAPAHRQRQRPPRLSRYSVAHAQTRGTDPTVSGRWSALPAAEPDSTVRAHFQAELLLGRHGVLTKGAVGAEGVPGGFATLYKVLSTFEDAGRCQRGYFVESLGGAQFAVASTVDRLRSYLDNVDPERPEYHAVVLAATDPANPYGAALGWPTDSEAHRPGRKAGALVALVDGRLVWFLERGGRSLLSFGADADAQRAAAGALTDLVSAGRIPSLLVERINGVAVLDPDVDAERAVVQDALLGAGLSRTPRGLRLR" }, { "InterPro": [ { "InterPro-ID": "IPR000504", "InterPro-Name": "RRM_dom", "InterPro-Type": "DOMAIN", "Beg": 11, "End": 89 }, { "InterPro-ID": "IPR000504", "InterPro-Name": "RRM_dom", "InterPro-Type": "DOMAIN", "Beg": 192, "End": 264 }, { "InterPro-ID": "IPR000504", "InterPro-Name": "RRM_dom", "InterPro-Type": "DOMAIN", "Beg": 12, "End": 85 }, { "InterPro-ID": "IPR000504", "InterPro-Name": "RRM_dom", "InterPro-Type": "DOMAIN", "Beg": 295, "End": 366 }, { "InterPro-ID": "IPR000504", "InterPro-Name": "RRM_dom", "InterPro-Type": "DOMAIN", "Beg": 100, "End": 171 }, { "InterPro-ID": "IPR036053", "InterPro-Name": "PABP-dom", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 478, "End": 601 }, { "InterPro-ID": "IPR000504", "InterPro-Name": "RRM_dom", "InterPro-Type": "DOMAIN", "Beg": 191, "End": 268 }, { "InterPro-ID": "IPR012677", "InterPro-Name": "Nucleotide-bd_a/b_plait_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 9, "End": 92 }, { "InterPro-ID": "IPR012677", "InterPro-Name": "Nucleotide-bd_a/b_plait_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 93, "End": 183 }, { "InterPro-ID": "IPR012677", "InterPro-Name": "Nucleotide-bd_a/b_plait_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 186, "End": 271 }, { "InterPro-ID": "IPR000504", "InterPro-Name": "RRM_dom", "InterPro-Type": "DOMAIN", "Beg": 294, "End": 370 }, { "InterPro-ID": "IPR002004", "InterPro-Name": "PABP_HYD_C", "InterPro-Type": "DOMAIN", "Beg": 535, "End": 598 }, { "InterPro-ID": "IPR002004", "InterPro-Name": "PABP_HYD_C", "InterPro-Type": "DOMAIN", "Beg": 523, "End": 600 }, { "InterPro-ID": "IPR000504", "InterPro-Name": "RRM_dom", "InterPro-Type": "DOMAIN", "Beg": 99, "End": 175 }, { "InterPro-ID": "IPR034364", "InterPro-Name": "PABP_RRM1", "InterPro-Type": "DOMAIN", "Beg": 12, "End": 91 }, { "InterPro-ID": "IPR002004", "InterPro-Name": "PABP_HYD_C", "InterPro-Type": "DOMAIN", "Beg": 530, "End": 595 }, { "InterPro-ID": "IPR035979", "InterPro-Name": "RBD_domain_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 191, "End": 374 }, { "InterPro-ID": "IPR003954", "InterPro-Name": "RRM_dom_euk", "InterPro-Type": "DOMAIN", "Beg": 100, "End": 171 }, { "InterPro-ID": "IPR003954", "InterPro-Name": "RRM_dom_euk", "InterPro-Type": "DOMAIN", "Beg": 295, "End": 366 }, { "InterPro-ID": "IPR003954", "InterPro-Name": "RRM_dom_euk", "InterPro-Type": "DOMAIN", "Beg": 192, "End": 264 }, { "InterPro-ID": "IPR003954", "InterPro-Name": "RRM_dom_euk", "InterPro-Type": "DOMAIN", "Beg": 12, "End": 85 }, { "InterPro-ID": "IPR012677", "InterPro-Name": "Nucleotide-bd_a/b_plait_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 272, "End": 383 }, { "InterPro-ID": "IPR035979", "InterPro-Name": "RBD_domain_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 12, "End": 177 }, { "InterPro-ID": "IPR006515", "InterPro-Name": "PABP_1234", "InterPro-Type": "FAMILY", "Beg": 11, "End": 596 }, { "InterPro-ID": "IPR045305", "InterPro-Name": "RRM2_I_PABPs", "InterPro-Type": "DOMAIN", "Beg": 97, "End": 172 }, { "InterPro-ID": "IPR000504", "InterPro-Name": "RRM_dom", "InterPro-Type": "DOMAIN", "Beg": 296, "End": 363 }, { "InterPro-ID": "IPR000504", "InterPro-Name": "RRM_dom", "InterPro-Type": "DOMAIN", "Beg": 101, "End": 167 }, { "InterPro-ID": "IPR000504", "InterPro-Name": "RRM_dom", "InterPro-Type": "DOMAIN", "Beg": 193, "End": 261 }, { "InterPro-ID": "IPR000504", "InterPro-Name": "RRM_dom", "InterPro-Type": "DOMAIN", "Beg": 13, "End": 83 } ], "response#1": "MDTGGHGCSLSSLYVGDLHPDVTESMLYEMFSPIGNILSIRVCRDVATRRSLGYAYINFQQPADAERALDTMNFEVIKGQPIRIMWSHRDPGLRKSGMGNIFIKNLENSIDNKALYDTFSTFGSILSSKVVYNEHGSRGFGFVHFETHEAAQKAINTMNGMLLNDRKVFVGHFKSRQKREAELGARALGFTNIYVKNLHANVDEQRLQDLFSQFGNMQSVKVMRDSNGQSRGFGFVNFEKHEEAQKAVDHMNGKEVSGQLLYVGRAQKRAERQSELKRRFEQMKQERQNRYQGVNLYVKNLDDSINDERLKEVFSTYGVITSAKVMTESSHSKGFGFVCFSSPEEATKAVTEMNGRIVGTKPLYVALAQRKEERKAILTNQYRRRPSHPVLSSFQQPTSYLLPAVPQSTAQAVYYSSGSITPMQPDPRWTAQPHGPPSTCPPAASVVQPLSTTQHPCIHLRGASQVSSQVPHTQRVVNIGTQTTGPGGEGSSIPGQLLVPHRGTSAVHSAHGVQESAVYVPGHQPLTVSMLAAAPLHEQKQMIGERLYSLIHDACAPLTGKITGMLLELDNLELLLLLESPESLHAKIEEAVAVLQVHREMESTDRN", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more RRM_dom, RRM_dom, RRM_dom, RRM_dom, RRM_dom, RRM_dom, RRM_dom, PABP_HYD_C, PABP_HYD_C, RRM_dom, PABP_RRM1, PABP_HYD_C, RRM_dom_euk, RRM_dom_euk, RRM_dom_euk, RRM_dom_euk, RRM2_I_PABPs, RRM_dom, RRM_dom, RRM_dom, RRM_dom that are essential for its biological function; 2. The protein should belong to PABP_1234 that shares evolutionary origin and functional similarity; 3. The protein should be classified within PABP-dom, Nucleotide-bd_a/b_plait_sf, Nucleotide-bd_a/b_plait_sf, Nucleotide-bd_a/b_plait_sf, RBD_domain_sf, Nucleotide-bd_a/b_plait_sf, RBD_domain_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MDTGGHGCSLSSLYVGDLHPDVTESMLYEMFSPIGNILSIRVCRDVATRRSLGYAYINFQQPADAERALDTMNFEVIKGQPIRIMWSHRDPGLRKSGMGNIFIKNLENSIDNKALYDTFSTFGSILSSKVVYNEHGSRGFGFVHFETHEAAQKAINTMNGMLLNDRKVFVGHFKSRQKREAELGARALGFTNIYVKNLHANVDEQRLQDLFSQFGNMQSVKVMRDSNGQSRGFGFVNFEKHEEAQKAVDHMNGKEVSGQLLYVGRAQKRAERQSELKRRFEQMKQERQNRYQGVNLYVKNLDDSINDERLKEVFSTYGVITSAKVMTESSHSKGFGFVCFSSPEEATKAVTEMNGRIVGTKPLYVALAQRKEERKAILTNQYRRRPSHPVLSSFQQPTSYLLPAVPQSTAQAVYYSSGSITPMQPDPRWTAQPHGPPSTCPPAASVVQPLSTTQHPCIHLRGASQVSSQVPHTQRVVNIGTQTTGPGGEGSSIPGQLLVPHRGTSAVHSAHGVQESAVYVPGHQPLTVSMLAAAPLHEQKQMIGERLYSLIHDACAPLTGKITGMLLELDNLELLLLLESPESLHAKIEEAVAVLQVHREMESTDRN" }, { "InterPro": [ { "InterPro-ID": "IPR001360", "InterPro-Name": "Glyco_hydro_1", "InterPro-Type": "FAMILY", "Beg": 22, "End": 515 }, { "InterPro-ID": "IPR001360", "InterPro-Name": "Glyco_hydro_1", "InterPro-Type": "FAMILY", "Beg": 232, "End": 514 }, { "InterPro-ID": "IPR001360", "InterPro-Name": "Glyco_hydro_1", "InterPro-Type": "FAMILY", "Beg": 20, "End": 201 }, { "InterPro-ID": "IPR001360", "InterPro-Name": "Glyco_hydro_1", "InterPro-Type": "FAMILY", "Beg": 462, "End": 479 }, { "InterPro-ID": "IPR001360", "InterPro-Name": "Glyco_hydro_1", "InterPro-Type": "FAMILY", "Beg": 341, "End": 355 }, { "InterPro-ID": "IPR001360", "InterPro-Name": "Glyco_hydro_1", "InterPro-Type": "FAMILY", "Beg": 418, "End": 426 }, { "InterPro-ID": "IPR001360", "InterPro-Name": "Glyco_hydro_1", "InterPro-Type": "FAMILY", "Beg": 486, "End": 498 }, { "InterPro-ID": "IPR001360", "InterPro-Name": "Glyco_hydro_1", "InterPro-Type": "FAMILY", "Beg": 441, "End": 452 }, { "InterPro-ID": "IPR017853", "InterPro-Name": "Glycoside_hydrolase_SF", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 17, "End": 511 }, { "InterPro-ID": "IPR033132", "InterPro-Name": "Glyco_hydro_1_N_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 26, "End": 40 } ], "response#1": "MSSVLPTPVLPTPGRNINRGHFPDDFIFGAGTSSYQIEGAAREGGRGPSIWDTFTHTHPELIQDGSNGDTAINSYNLYKEDIKIVKLMGLDAYRFSISWPRILPGGSINAGINQEGIKYYNNLIDELLANDIVPYVTLFHWDVPQALQDQYDGFLSDKIVDDFRDFAELCFWEFGDRVKNWITINEPESYSNFFGVAYDTPPKAHALKASRLLVPTTVARPSKPVRVFASTADPGTTTADQVYKVGHNLLLAHAAAIQVYRDKFQNTQEGTFGMALVTQWMKPLNENNPADVEAASRAFDFKFGWFMQPLITGEYPKSMRQLLGPRLREFTPDQKKLLIGSYDYVGVNYYTATYVSSAQPPHDKKKAVFHTDGNFYTTDSKDGVLIGPLAGPAWLNIVPEGIYHVLQDIKENYEDPVIYITENGVYEVNDTAKTLSEARVDTTRLHYLQDHLSKVLEARHQGVRVQGYLVWSLMDNWELRAGYTSRFGLIHIDYYNNFARYPKDSAIWFRNAFHKRLRIHVNKARPQEDDGAFDTPRKRLRKY", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Glyco_hydro_1, Glyco_hydro_1, Glyco_hydro_1, Glyco_hydro_1, Glyco_hydro_1, Glyco_hydro_1, Glyco_hydro_1, Glyco_hydro_1 that shares evolutionary origin and functional similarity; 2. The protein should be classified within Glycoside_hydrolase_SF sharing conserved structural features; 3. The protein should contain Glyco_hydro_1_N_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MSSVLPTPVLPTPGRNINRGHFPDDFIFGAGTSSYQIEGAAREGGRGPSIWDTFTHTHPELIQDGSNGDTAINSYNLYKEDIKIVKLMGLDAYRFSISWPRILPGGSINAGINQEGIKYYNNLIDELLANDIVPYVTLFHWDVPQALQDQYDGFLSDKIVDDFRDFAELCFWEFGDRVKNWITINEPESYSNFFGVAYDTPPKAHALKASRLLVPTTVARPSKPVRVFASTADPGTTTADQVYKVGHNLLLAHAAAIQVYRDKFQNTQEGTFGMALVTQWMKPLNENNPADVEAASRAFDFKFGWFMQPLITGEYPKSMRQLLGPRLREFTPDQKKLLIGSYDYVGVNYYTATYVSSAQPPHDKKKAVFHTDGNFYTTDSKDGVLIGPLAGPAWLNIVPEGIYHVLQDIKENYEDPVIYITENGVYEVNDTAKTLSEARVDTTRLHYLQDHLSKVLEARHQGVRVQGYLVWSLMDNWELRAGYTSRFGLIHIDYYNNFARYPKDSAIWFRNAFHKRLRIHVNKARPQEDDGAFDTPRKRLRKY" }, { "InterPro": [ { "InterPro-ID": "IPR029057", "InterPro-Name": "PRTase-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 100, "End": 220 }, { "InterPro-ID": "IPR029057", "InterPro-Name": "PRTase-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 51, "End": 219 }, { "InterPro-ID": "IPR000836", "InterPro-Name": "PRibTrfase_dom", "InterPro-Type": "DOMAIN", "Beg": 102, "End": 219 }, { "InterPro-ID": "IPR000836", "InterPro-Name": "PRibTrfase_dom", "InterPro-Type": "DOMAIN", "Beg": 176, "End": 219 }, { "InterPro-ID": "IPR051910", "InterPro-Name": "ComF/GntX_DNA_util-trans", "InterPro-Type": "FAMILY", "Beg": 2, "End": 220 } ], "response#1": "MKCLLCGQTMKTVLTFSSLLLLRNDDSCLCSDCDSTFERIGEENCPNCMKTELSTKCQDCQLWCKEGVGVSHRAIFTYNQAMKDFFSRYKFDGDFLLRKVFASFLSEELKKYKEYQFVVIPLSPDRYANRGFNQVEGLVEAAGFEYLDLLEKREERASSSKNRSERLGTELPFFIKSGVTIPKKILLIDDIYTTGATINRVKKLLEEAGAKDVKTFSLVR", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more PRibTrfase_dom, PRibTrfase_dom that are essential for its biological function; 2. The protein should belong to ComF/GntX_DNA_util-trans that shares evolutionary origin and functional similarity; 3. The protein should be classified within PRTase-like, PRTase-like sharing conserved structural features. The designed protein sequence is ", "reference": "MKCLLCGQTMKTVLTFSSLLLLRNDDSCLCSDCDSTFERIGEENCPNCMKTELSTKCQDCQLWCKEGVGVSHRAIFTYNQAMKDFFSRYKFDGDFLLRKVFASFLSEELKKYKEYQFVVIPLSPDRYANRGFNQVEGLVEAAGFEYLDLLEKREERASSSKNRSERLGTELPFFIKSGVTIPKKILLIDDIYTTGATINRVKKLLEEAGAKDVKTFSLVR" }, { "InterPro": [ { "InterPro-ID": "IPR010636", "InterPro-Name": "Cerato-ulmin_hydrophobin", "InterPro-Type": "FAMILY", "Beg": 28, "End": 93 }, { "InterPro-ID": "IPR010636", "InterPro-Name": "Cerato-ulmin_hydrophobin", "InterPro-Type": "FAMILY", "Beg": 1, "End": 95 }, { "InterPro-ID": "IPR036686", "InterPro-Name": "Hydrophobin_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 17, "End": 98 }, { "InterPro-ID": "IPR010636", "InterPro-Name": "Cerato-ulmin_hydrophobin", "InterPro-Type": "FAMILY", "Beg": 29, "End": 95 }, { "InterPro-ID": "IPR036686", "InterPro-Name": "Hydrophobin_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 29, "End": 98 } ], "response#1": "MQFYAIASLFLAGTAFAAPATSPNGYDACPDGGLIGTPQCCSLDLVGVLSGECSSPSKTPNSAKEFQEICAASGQKARCCFLSEVFTLGAFCQKPVGVTA", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Cerato-ulmin_hydrophobin, Cerato-ulmin_hydrophobin, Cerato-ulmin_hydrophobin that shares evolutionary origin and functional similarity; 2. The protein should be classified within Hydrophobin_sf, Hydrophobin_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MQFYAIASLFLAGTAFAAPATSPNGYDACPDGGLIGTPQCCSLDLVGVLSGECSSPSKTPNSAKEFQEICAASGQKARCCFLSEVFTLGAFCQKPVGVTA" }, { "InterPro": [ { "InterPro-ID": "IPR026890", "InterPro-Name": "Mononeg_mRNAcap", "InterPro-Type": "DOMAIN", "Beg": 1142, "End": 1385 }, { "InterPro-ID": "IPR025786", "InterPro-Name": "Mononega_L_MeTrfase", "InterPro-Type": "DOMAIN", "Beg": 1781, "End": 1994 }, { "InterPro-ID": "IPR014023", "InterPro-Name": "Mononeg_RNA_pol_cat", "InterPro-Type": "DOMAIN", "Beg": 11, "End": 1123 }, { "InterPro-ID": "IPR016269", "InterPro-Name": "RNA-dir_pol_paramyxovirus", "InterPro-Type": "FAMILY", "Beg": 1, "End": 2233 }, { "InterPro-ID": "IPR014023", "InterPro-Name": "Mononeg_RNA_pol_cat", "InterPro-Type": "DOMAIN", "Beg": 662, "End": 846 }, { "InterPro-ID": "IPR039736", "InterPro-Name": "L_poly_C", "InterPro-Type": "DOMAIN", "Beg": 1245, "End": 2231 } ], "response#1": "MAGLNEILLPEVHLNSPIVRYKLFYYILHGQLPNDLEPDDLGPLANQNWKAIRAEESQVHARLKQIRVELIARIPSLRWTRSQREIAILIWPRILPILQAYDLRQSMQLPTVWEKLTQSTVNLISDGLERVVLHISNQLTGKPNLFTRSRAGQDTKDYSIPSTRELSQIWFNNEWSGSVKTWLMIKYRMRQLITNQKTGELTDLVTIVDTRSTLCIITPELVALYSSEHKALTYLTFEMVLMVTDMLEGRLNVSSLCTASHYLSPLKKRIEVLLTLVDDLALLMGDKVYGIVSSLESFVYAQLQYGDPVIDIKGTFYGFICNEILDLLTEDNIFTEEEANKVLLDLTSQFDNLSPDLTAELLCIMRLWGHPTLTASQAASKVRESMCAPKVLDFQTIMKTLAFFHAILINGYRRSHNGIWPPTTLHGNAPKSLIEMRHDNSELKYEYVLKNWKSISMLRIHKCFDASPDEDLSIFMKDKAISCPRQDWMGVFRRSLIKQRYRDANRPLPQPFNRRLLLNFLEDDRFDPIKELEYVTSGEYLRDPEFCASYSLKEKEIKATGRIFAKMTKRMRSCQVIAESLLANHAGKLMRENGVVLDQLKLTKSLLTMNQIGIISEHSRRSTADNMTLAHSGSNKHRINNSQFKKNKDNKHEMPDDGFEIAACFLTTDLTKYCLNWRYQVIIPFARTLNSMYGIPHLFEWIHLRLMRSTLYVGDPFNPPSDPTQLDLDTALNDDIFIVSPRGGIEGLCQKLWTMISISTIILSATEANTRVMSMVQGDNQAIAITTRVVRSLSHSEKKEQAYKASKLFFERLRANNHGIGHHLKEQETILSSDFFIYSKRVFYKGRILTQALKNVSKMCLTADILGDCSQASCSNLATTVMRLTENGVEKDLCYFLNAFMTIRQLCYDLVFPQTKSLSQDITNAYLNHPILISRLCLLPSQLGGLNFLSCSRLFNRNIGDPLVSAIADVKRLIKAGCLDIWVLYNILGRRPGKGKWSTLAADPYTLNIDYLVPSTTFLKKHAQYTLMERSVNPMLRGVFSENAAEEEEELAQYLLDREVVMPRVAHVILAQSSCGRRKQIQGYLDSTRTIIRYSLEVRPLSAKKLNTVIEYNLLYLSYNLEIIEKPNIVQPFLNAINVDTCSIDIARSLRKLSWATLLNGRPIEGLETPDPIELVHGCLIIGSDECEHCSSGDDKFTWFFLPKGIRLDDDPASNPPIRVPYIGSKTDERRVASMAYIKGASVSLKSALRLAGVYIWAFGDTEESWQDAYELASTRVNLTLEQLQSLTPLPTSANLVHRLDDGTTQLKFTPASSYAFSSFVHISNDCQILEIDDQVTDSNLIYQQVMITGLALIETWNNPPINFSVYETTLHLHTGSSCCIRPVESCVVNPPLLPVPLINVPQMNKFVYDPEPLSLLEMEKIEDIAYQTRIGGLDQIPLLEKIPLLAHLTAKQMVNSITGLDEATSIMNDAVVQADYTSNWISECCYTYIDSVFVYSGWALLLELSYQMYYLRIQGIQGILDYVYMTLRRIPGMAITGISSTISHPRILRRCINLDVIAPINSPHIASLDYTKLSIDAVMWGTKQVLTNISQGIDYEIVVPSESQLTLSDRVLNLVARKLSLLAIIWANYNYPPKVKGMSPEDKCQALTTHLLQTVEYVEYIQIEKTNIRRMIIEPKLTAYPSNLFYLSRKLLNAIRDSEEGQFLIASYYNSFGYLEPILMESKIFNLSSSESASLTEFDFILNLELSDASLEKYSLPSLLMTAENMDNPFPQPPLHHVLRPLGLSSTSWYKTISVLNYISHMKISDGAHLYLAEGSGASMSLIETFLPGETIWYNSLFNSGENPPQRNFAPLPTQFIESVPYRLIQAGIAAGNGIVQSFYPLWNGNSDITDLSTKTSVEYIIHKVGADTCALVHVDLEGVPGSMNSMLERAQVHALLITVTVLKPGGLLILKASWEPFNRFSFLLTVLWQFFSTIRILRSSYSDPNNHEVYIIATLAVDPTTSSFTTALNRARTLNEQGFSLIPPELVSEYWRKRVEQGQIIQDCIDKVISECVRDQYLADNNIILQAGGTPSTRKWLDLPDYSSFNELQSEMARLITIHLKEVIEILKGQASDHDTLLFTSYNVGPLGKINTILRLIVERILMYTVRNWCILPTQTRLTLRQSIELGEFRLRDVITPMEILKLSPNRKYLKSALNQSTFNHLMGETSDILLNRAYQKRIWKAIGCVIYCFGLLTPDVEGSERIDVDNDIPDYDIHGDII", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Mononeg_mRNAcap, Mononega_L_MeTrfase, Mononeg_RNA_pol_cat, Mononeg_RNA_pol_cat, L_poly_C that are essential for its biological function; 2. The protein should belong to RNA-dir_pol_paramyxovirus that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MAGLNEILLPEVHLNSPIVRYKLFYYILHGQLPNDLEPDDLGPLANQNWKAIRAEESQVHARLKQIRVELIARIPSLRWTRSQREIAILIWPRILPILQAYDLRQSMQLPTVWEKLTQSTVNLISDGLERVVLHISNQLTGKPNLFTRSRAGQDTKDYSIPSTRELSQIWFNNEWSGSVKTWLMIKYRMRQLITNQKTGELTDLVTIVDTRSTLCIITPELVALYSSEHKALTYLTFEMVLMVTDMLEGRLNVSSLCTASHYLSPLKKRIEVLLTLVDDLALLMGDKVYGIVSSLESFVYAQLQYGDPVIDIKGTFYGFICNEILDLLTEDNIFTEEEANKVLLDLTSQFDNLSPDLTAELLCIMRLWGHPTLTASQAASKVRESMCAPKVLDFQTIMKTLAFFHAILINGYRRSHNGIWPPTTLHGNAPKSLIEMRHDNSELKYEYVLKNWKSISMLRIHKCFDASPDEDLSIFMKDKAISCPRQDWMGVFRRSLIKQRYRDANRPLPQPFNRRLLLNFLEDDRFDPIKELEYVTSGEYLRDPEFCASYSLKEKEIKATGRIFAKMTKRMRSCQVIAESLLANHAGKLMRENGVVLDQLKLTKSLLTMNQIGIISEHSRRSTADNMTLAHSGSNKHRINNSQFKKNKDNKHEMPDDGFEIAACFLTTDLTKYCLNWRYQVIIPFARTLNSMYGIPHLFEWIHLRLMRSTLYVGDPFNPPSDPTQLDLDTALNDDIFIVSPRGGIEGLCQKLWTMISISTIILSATEANTRVMSMVQGDNQAIAITTRVVRSLSHSEKKEQAYKASKLFFERLRANNHGIGHHLKEQETILSSDFFIYSKRVFYKGRILTQALKNVSKMCLTADILGDCSQASCSNLATTVMRLTENGVEKDLCYFLNAFMTIRQLCYDLVFPQTKSLSQDITNAYLNHPILISRLCLLPSQLGGLNFLSCSRLFNRNIGDPLVSAIADVKRLIKAGCLDIWVLYNILGRRPGKGKWSTLAADPYTLNIDYLVPSTTFLKKHAQYTLMERSVNPMLRGVFSENAAEEEEELAQYLLDREVVMPRVAHVILAQSSCGRRKQIQGYLDSTRTIIRYSLEVRPLSAKKLNTVIEYNLLYLSYNLEIIEKPNIVQPFLNAINVDTCSIDIARSLRKLSWATLLNGRPIEGLETPDPIELVHGCLIIGSDECEHCSSGDDKFTWFFLPKGIRLDDDPASNPPIRVPYIGSKTDERRVASMAYIKGASVSLKSALRLAGVYIWAFGDTEESWQDAYELASTRVNLTLEQLQSLTPLPTSANLVHRLDDGTTQLKFTPASSYAFSSFVHISNDCQILEIDDQVTDSNLIYQQVMITGLALIETWNNPPINFSVYETTLHLHTGSSCCIRPVESCVVNPPLLPVPLINVPQMNKFVYDPEPLSLLEMEKIEDIAYQTRIGGLDQIPLLEKIPLLAHLTAKQMVNSITGLDEATSIMNDAVVQADYTSNWISECCYTYIDSVFVYSGWALLLELSYQMYYLRIQGIQGILDYVYMTLRRIPGMAITGISSTISHPRILRRCINLDVIAPINSPHIASLDYTKLSIDAVMWGTKQVLTNISQGIDYEIVVPSESQLTLSDRVLNLVARKLSLLAIIWANYNYPPKVKGMSPEDKCQALTTHLLQTVEYVEYIQIEKTNIRRMIIEPKLTAYPSNLFYLSRKLLNAIRDSEEGQFLIASYYNSFGYLEPILMESKIFNLSSSESASLTEFDFILNLELSDASLEKYSLPSLLMTAENMDNPFPQPPLHHVLRPLGLSSTSWYKTISVLNYISHMKISDGAHLYLAEGSGASMSLIETFLPGETIWYNSLFNSGENPPQRNFAPLPTQFIESVPYRLIQAGIAAGNGIVQSFYPLWNGNSDITDLSTKTSVEYIIHKVGADTCALVHVDLEGVPGSMNSMLERAQVHALLITVTVLKPGGLLILKASWEPFNRFSFLLTVLWQFFSTIRILRSSYSDPNNHEVYIIATLAVDPTTSSFTTALNRARTLNEQGFSLIPPELVSEYWRKRVEQGQIIQDCIDKVISECVRDQYLADNNIILQAGGTPSTRKWLDLPDYSSFNELQSEMARLITIHLKEVIEILKGQASDHDTLLFTSYNVGPLGKINTILRLIVERILMYTVRNWCILPTQTRLTLRQSIELGEFRLRDVITPMEILKLSPNRKYLKSALNQSTFNHLMGETSDILLNRAYQKRIWKAIGCVIYCFGLLTPDVEGSERIDVDNDIPDYDIHGDII" }, { "InterPro": [ { "InterPro-ID": "IPR037534", "InterPro-Name": "INFV_PA", "InterPro-Type": "FAMILY", "Beg": 1, "End": 716 }, { "InterPro-ID": "IPR001009", "InterPro-Name": "PA/PA-X", "InterPro-Type": "FAMILY", "Beg": 21, "End": 714 }, { "InterPro-ID": "IPR038372", "InterPro-Name": "PA/PA-X_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1, "End": 198 } ], "response#1": "MEDFVRQCFNPMIVELAEKAMKEYGEDPKIETNKFAAICTHLEVCFMYSDFHFIDERGESIIVESGDPNALLKHRFEIIEGRDRIMAWTVVNSICNTTGVEKPKFLPDLYDYKENRFIEIGVTRREVHIYYLEKANKIKSEKTHIHIFSFTGEEMATKADYTLDEESRARIKTRLFTIRQEMASRSLWDSFRQSERGEETIEEKFEITGTMRKLADQSLPPNFPSLENFRAYVDGFEPNGCIEGKLSQMSKEVNAKIEPFLRTTPRPLRLPDGPLCHQRSKFLLMDALKLSIEDPSHEGEGIPLYDAIKCMKTFFGWKEPNIVKPHEKGINPNYLMAWKQVLAELQDIENEEKIPRTKNMKRTSQLKWALGENMAPEKVDFDDCKDVGDLKQYDSDEPEPRSLASWVQNEFNKACELTDSSWIELDEIGEDVAPIEHIASMRRNYFTAEVSHCRATEYIMKGVYINTALLNASCAAMDDFQLIPMISKCRTKEGRRKTNLYGFIIKGRSHLRNDTDVVNFVSMEFSLTDPRLEPHKWEKYCVLEIGDMLLRTAIGQVSRPMFLYVRTNGTSKIKMKWGMEMRRCLLQSLQQIESMIEAESSVKEKDMTKEFFENKSETWPIGESPRGVEEGSIGKVCRTLLAKSVFNSLYASPQLEGFSAESRKLLLIVQALRDNLEPGTFDLGGLYEAIEECLINDPWVLLNASWFNSFLTHALK", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to INFV_PA, PA/PA-X that shares evolutionary origin and functional similarity; 2. The protein should be classified within PA/PA-X_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MEDFVRQCFNPMIVELAEKAMKEYGEDPKIETNKFAAICTHLEVCFMYSDFHFIDERGESIIVESGDPNALLKHRFEIIEGRDRIMAWTVVNSICNTTGVEKPKFLPDLYDYKENRFIEIGVTRREVHIYYLEKANKIKSEKTHIHIFSFTGEEMATKADYTLDEESRARIKTRLFTIRQEMASRSLWDSFRQSERGEETIEEKFEITGTMRKLADQSLPPNFPSLENFRAYVDGFEPNGCIEGKLSQMSKEVNAKIEPFLRTTPRPLRLPDGPLCHQRSKFLLMDALKLSIEDPSHEGEGIPLYDAIKCMKTFFGWKEPNIVKPHEKGINPNYLMAWKQVLAELQDIENEEKIPRTKNMKRTSQLKWALGENMAPEKVDFDDCKDVGDLKQYDSDEPEPRSLASWVQNEFNKACELTDSSWIELDEIGEDVAPIEHIASMRRNYFTAEVSHCRATEYIMKGVYINTALLNASCAAMDDFQLIPMISKCRTKEGRRKTNLYGFIIKGRSHLRNDTDVVNFVSMEFSLTDPRLEPHKWEKYCVLEIGDMLLRTAIGQVSRPMFLYVRTNGTSKIKMKWGMEMRRCLLQSLQQIESMIEAESSVKEKDMTKEFFENKSETWPIGESPRGVEEGSIGKVCRTLLAKSVFNSLYASPQLEGFSAESRKLLLIVQALRDNLEPGTFDLGGLYEAIEECLINDPWVLLNASWFNSFLTHALK" }, { "InterPro": [ { "InterPro-ID": "IPR029063", "InterPro-Name": "SAM-dependent_MTases_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 101, "End": 350 }, { "InterPro-ID": "IPR016461", "InterPro-Name": "COMT-like", "InterPro-Type": "FAMILY", "Beg": 13, "End": 332 }, { "InterPro-ID": "IPR029063", "InterPro-Name": "SAM-dependent_MTases_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 104, "End": 347 }, { "InterPro-ID": "IPR016461", "InterPro-Name": "COMT-like", "InterPro-Type": "FAMILY", "Beg": 20, "End": 350 }, { "InterPro-ID": "IPR036390", "InterPro-Name": "WH_DNA-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 9, "End": 104 }, { "InterPro-ID": "IPR036388", "InterPro-Name": "WH-like_DNA-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 2, "End": 99 }, { "InterPro-ID": "IPR001077", "InterPro-Name": "O_MeTrfase_dom", "InterPro-Type": "DOMAIN", "Beg": 123, "End": 332 }, { "InterPro-ID": "IPR016461", "InterPro-Name": "COMT-like", "InterPro-Type": "FAMILY", "Beg": 1, "End": 350 }, { "InterPro-ID": "IPR012967", "InterPro-Name": "Plant_O-MeTrfase_dimerisation", "InterPro-Type": "DOMAIN", "Beg": 13, "End": 102 } ], "response#1": "METVESSSSAELLRAQTHFSRQVFSFQNFAALKCALQLGIPDAIKQHGKPMNLSELTSALPINPSKAPCIHRLMRLLVNAGYFAQENECFALTSLGRLLLKDDPLHIRALVLSEFHTALVMPWFALSEWFKNDDVAPFATAHGKSFWDYTSCDPELRNVFDGAMACDSHLIAKALVTEFKYLFEGLKSLVDVGGGNGTLARSIAKAFTNLKCTVCDLPEAVANEQGDGNLDFVAGDMFDRVPSADAILLKSILHDWSDENCVKILKNCKRAISGKDKGGKVIVIDGVVELQKKAGNDDPGLDNMDMQMLVLFNSKERNEKEWAKLFSDAGFSDYGIVRTFGWWCIMELSP", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more O_MeTrfase_dom, Plant_O-MeTrfase_dimerisation that are essential for its biological function; 2. The protein should belong to COMT-like, COMT-like, COMT-like that shares evolutionary origin and functional similarity; 3. The protein should be classified within SAM-dependent_MTases_sf, SAM-dependent_MTases_sf, WH_DNA-bd_sf, WH-like_DNA-bd_sf sharing conserved structural features. The designed protein sequence is ", "reference": "METVESSSSAELLRAQTHFSRQVFSFQNFAALKCALQLGIPDAIKQHGKPMNLSELTSALPINPSKAPCIHRLMRLLVNAGYFAQENECFALTSLGRLLLKDDPLHIRALVLSEFHTALVMPWFALSEWFKNDDVAPFATAHGKSFWDYTSCDPELRNVFDGAMACDSHLIAKALVTEFKYLFEGLKSLVDVGGGNGTLARSIAKAFTNLKCTVCDLPEAVANEQGDGNLDFVAGDMFDRVPSADAILLKSILHDWSDENCVKILKNCKRAISGKDKGGKVIVIDGVVELQKKAGNDDPGLDNMDMQMLVLFNSKERNEKEWAKLFSDAGFSDYGIVRTFGWWCIMELSP" }, { "InterPro": [ { "InterPro-ID": "IPR001077", "InterPro-Name": "O_MeTrfase_dom", "InterPro-Type": "DOMAIN", "Beg": 123, "End": 332 }, { "InterPro-ID": "IPR036388", "InterPro-Name": "WH-like_DNA-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 2, "End": 99 }, { "InterPro-ID": "IPR016461", "InterPro-Name": "COMT-like", "InterPro-Type": "FAMILY", "Beg": 1, "End": 350 }, { "InterPro-ID": "IPR016461", "InterPro-Name": "COMT-like", "InterPro-Type": "FAMILY", "Beg": 20, "End": 350 }, { "InterPro-ID": "IPR029063", "InterPro-Name": "SAM-dependent_MTases_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 103, "End": 347 }, { "InterPro-ID": "IPR029063", "InterPro-Name": "SAM-dependent_MTases_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 101, "End": 350 }, { "InterPro-ID": "IPR016461", "InterPro-Name": "COMT-like", "InterPro-Type": "FAMILY", "Beg": 13, "End": 335 }, { "InterPro-ID": "IPR036390", "InterPro-Name": "WH_DNA-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 9, "End": 104 }, { "InterPro-ID": "IPR012967", "InterPro-Name": "Plant_O-MeTrfase_dimerisation", "InterPro-Type": "DOMAIN", "Beg": 13, "End": 101 } ], "response#1": "METVESSSSAELLRAQTHFSTQLFSFQNYASLKCALHLGIPDAIKQHGKPMNLSELTSALPINPSKAPYIHRLMRMLVKAGYFAQENECFDLTPIGLLLLKDDPINIRALVLLELHPALLMPWIALSEWFQNDDATPFVTAHGKSFWDYTSRDPEFRKLFDEAMAGDSELISKVLVTEFKYVFEGLKSLVDVGGGNGTLARSIAKAFPNLKCTVFDLPEAVANEQGDGNLDFVAGDMFDRVPSADAILLKIILHDWSDENCVKILKNCKKSIPGKDKGGKVIIIEGVVELEKNAGNEYAGLENLDMEMMVLYNSKERTKKEWAKLFSDAGFSDYKFIPALDSWCIIELSP", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more O_MeTrfase_dom, Plant_O-MeTrfase_dimerisation that are essential for its biological function; 2. The protein should belong to COMT-like, COMT-like, COMT-like that shares evolutionary origin and functional similarity; 3. The protein should be classified within WH-like_DNA-bd_sf, SAM-dependent_MTases_sf, SAM-dependent_MTases_sf, WH_DNA-bd_sf sharing conserved structural features. The designed protein sequence is ", "reference": "METVESSSSAELLRAQTHFSTQLFSFQNYASLKCALHLGIPDAIKQHGKPMNLSELTSALPINPSKAPYIHRLMRMLVKAGYFAQENECFDLTPIGLLLLKDDPINIRALVLLELHPALLMPWIALSEWFQNDDATPFVTAHGKSFWDYTSRDPEFRKLFDEAMAGDSELISKVLVTEFKYVFEGLKSLVDVGGGNGTLARSIAKAFPNLKCTVFDLPEAVANEQGDGNLDFVAGDMFDRVPSADAILLKIILHDWSDENCVKILKNCKKSIPGKDKGGKVIIIEGVVELEKNAGNEYAGLENLDMEMMVLYNSKERTKKEWAKLFSDAGFSDYKFIPALDSWCIIELSP" }, { "InterPro": [ { "InterPro-ID": "IPR036388", "InterPro-Name": "WH-like_DNA-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 2, "End": 99 }, { "InterPro-ID": "IPR029063", "InterPro-Name": "SAM-dependent_MTases_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 104, "End": 342 }, { "InterPro-ID": "IPR016461", "InterPro-Name": "COMT-like", "InterPro-Type": "FAMILY", "Beg": 1, "End": 357 }, { "InterPro-ID": "IPR029063", "InterPro-Name": "SAM-dependent_MTases_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 101, "End": 355 }, { "InterPro-ID": "IPR036390", "InterPro-Name": "WH_DNA-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 9, "End": 104 }, { "InterPro-ID": "IPR016461", "InterPro-Name": "COMT-like", "InterPro-Type": "FAMILY", "Beg": 20, "End": 356 }, { "InterPro-ID": "IPR016461", "InterPro-Name": "COMT-like", "InterPro-Type": "FAMILY", "Beg": 15, "End": 338 }, { "InterPro-ID": "IPR001077", "InterPro-Name": "O_MeTrfase_dom", "InterPro-Type": "DOMAIN", "Beg": 123, "End": 336 }, { "InterPro-ID": "IPR012967", "InterPro-Name": "Plant_O-MeTrfase_dimerisation", "InterPro-Type": "DOMAIN", "Beg": 13, "End": 102 } ], "response#1": "METVESSSSAELLRAQMHFSTQLFGFHYTAALKCAVKLGIPDAIKQHGKPMNLSELNSALSINPSKAPCIHRLMRILVTAGYFAQENECFSLTSAGRHFLKDDPLNIRALVLLELHPALVKPWIALGEWFQNDDVSPFATAHGKSFWDYVTSDPELRKLFDESMADDSQLIAKALVTEFRYVFEGLKSLVDVGGGSGTLARAIAKAFPNLKCTVCDLPDAVANEHGDGNLDFVAGDMFERVPSADSILLKHILHDWSDEKCVEILKKCREAIPKNGGKVIIVDKLLKNRGHGHAENEHDEATESPLSCDMEMLVLVNGKERDEKEWAKLFSGAGFNDYKYNITPVLGSTSLIEVNFYN", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more O_MeTrfase_dom, Plant_O-MeTrfase_dimerisation that are essential for its biological function; 2. The protein should belong to COMT-like, COMT-like, COMT-like that shares evolutionary origin and functional similarity; 3. The protein should be classified within WH-like_DNA-bd_sf, SAM-dependent_MTases_sf, SAM-dependent_MTases_sf, WH_DNA-bd_sf sharing conserved structural features. The designed protein sequence is ", "reference": "METVESSSSAELLRAQMHFSTQLFGFHYTAALKCAVKLGIPDAIKQHGKPMNLSELNSALSINPSKAPCIHRLMRILVTAGYFAQENECFSLTSAGRHFLKDDPLNIRALVLLELHPALVKPWIALGEWFQNDDVSPFATAHGKSFWDYVTSDPELRKLFDESMADDSQLIAKALVTEFRYVFEGLKSLVDVGGGSGTLARAIAKAFPNLKCTVCDLPDAVANEHGDGNLDFVAGDMFERVPSADSILLKHILHDWSDEKCVEILKKCREAIPKNGGKVIIVDKLLKNRGHGHAENEHDEATESPLSCDMEMLVLVNGKERDEKEWAKLFSGAGFNDYKYNITPVLGSTSLIEVNFYN" }, { "InterPro": [ { "InterPro-ID": "IPR014861", "InterPro-Name": "CNP1-like_dom", "InterPro-Type": "DOMAIN", "Beg": 41, "End": 188 } ], "response#1": "MRRAILLILTLTVGTSLAAGFSQKDTPINTRYRETPEEAAAREFKEHTAELPPLPDAHSDGWFDIYVDENYGKQPKILLDSLQIMPAPDGSIRYILNIRSDKGYDNLTAEGIFCARSSIGFGNGKLSSYKVFGYGDTVNSRWIQPRNAEWKPIGGTLGRNDALRAVLYQAFCEGGVPADTQGLVQRLKERAGRYAPSMKPHDK", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more CNP1-like_dom that are essential for its biological function. The designed protein sequence is ", "reference": "MRRAILLILTLTVGTSLAAGFSQKDTPINTRYRETPEEAAAREFKEHTAELPPLPDAHSDGWFDIYVDENYGKQPKILLDSLQIMPAPDGSIRYILNIRSDKGYDNLTAEGIFCARSSIGFGNGKLSSYKVFGYGDTVNSRWIQPRNAEWKPIGGTLGRNDALRAVLYQAFCEGGVPADTQGLVQRLKERAGRYAPSMKPHDK" }, { "InterPro": [ { "InterPro-ID": "IPR000276", "InterPro-Name": "GPCR_Rhodpsn", "InterPro-Type": "FAMILY", "Beg": 230, "End": 254 }, { "InterPro-ID": "IPR000276", "InterPro-Name": "GPCR_Rhodpsn", "InterPro-Type": "FAMILY", "Beg": 141, "End": 162 }, { "InterPro-ID": "IPR000276", "InterPro-Name": "GPCR_Rhodpsn", "InterPro-Type": "FAMILY", "Beg": 190, "End": 213 }, { "InterPro-ID": "IPR000276", "InterPro-Name": "GPCR_Rhodpsn", "InterPro-Type": "FAMILY", "Beg": 27, "End": 51 }, { "InterPro-ID": "IPR000276", "InterPro-Name": "GPCR_Rhodpsn", "InterPro-Type": "FAMILY", "Beg": 276, "End": 302 }, { "InterPro-ID": "IPR000276", "InterPro-Name": "GPCR_Rhodpsn", "InterPro-Type": "FAMILY", "Beg": 60, "End": 81 }, { "InterPro-ID": "IPR000276", "InterPro-Name": "GPCR_Rhodpsn", "InterPro-Type": "FAMILY", "Beg": 105, "End": 127 }, { "InterPro-ID": "IPR000276", "InterPro-Name": "GPCR_Rhodpsn", "InterPro-Type": "FAMILY", "Beg": 43, "End": 294 }, { "InterPro-ID": "IPR000276", "InterPro-Name": "GPCR_Rhodpsn", "InterPro-Type": "FAMILY", "Beg": 111, "End": 127 }, { "InterPro-ID": "IPR002276", "InterPro-Name": "GPR4_orph", "InterPro-Type": "FAMILY", "Beg": 9, "End": 30 }, { "InterPro-ID": "IPR002276", "InterPro-Name": "GPR4_orph", "InterPro-Type": "FAMILY", "Beg": 182, "End": 191 }, { "InterPro-ID": "IPR002276", "InterPro-Name": "GPR4_orph", "InterPro-Type": "FAMILY", "Beg": 216, "End": 228 }, { "InterPro-ID": "IPR002276", "InterPro-Name": "GPR4_orph", "InterPro-Type": "FAMILY", "Beg": 156, "End": 174 }, { "InterPro-ID": "IPR002276", "InterPro-Name": "GPR4_orph", "InterPro-Type": "FAMILY", "Beg": 328, "End": 346 }, { "InterPro-ID": "IPR002276", "InterPro-Name": "GPR4_orph", "InterPro-Type": "FAMILY", "Beg": 132, "End": 144 }, { "InterPro-ID": "IPR002276", "InterPro-Name": "GPR4_orph", "InterPro-Type": "FAMILY", "Beg": 254, "End": 269 }, { "InterPro-ID": "IPR017452", "InterPro-Name": "GPCR_Rhodpsn_7TM", "InterPro-Type": "DOMAIN", "Beg": 42, "End": 294 } ], "response#1": "MASLRGSETMCNITTSCNVDSNIDQFFQPTLYIIVIVLGFPTNCMALWAAYMQVKQKNELGIYLMNLSIADLLYITTLPLWIDYFVHHDNWIHGQVSCKLFGFIFYTNIYVSIAFLCCISVDRYLAVAHPLKFAKVRRVKTALLVSAIVWLTEIVANSAPLFHDELFQDRFNHTFCFEKYPMEPWVAGMNLYRTFLGFLAPWGIMLAAYRGILRAVRGNVSTERQEKAKIKRLALSLILIVLLCFAPYHVLLLWRSVLFLINPCDCGGEENLFGAYHVTLALTSLNCVADPILYCFVNEGARHDVGRALATLLGLFQRGKSPETLMGASITVETPLAVKKPDFYSEVKTNAYKNDIEVLKDECLQMTILSVKK", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more GPCR_Rhodpsn_7TM that are essential for its biological function; 2. The protein should belong to GPCR_Rhodpsn, GPCR_Rhodpsn, GPCR_Rhodpsn, GPCR_Rhodpsn, GPCR_Rhodpsn, GPCR_Rhodpsn, GPCR_Rhodpsn, GPCR_Rhodpsn, GPCR_Rhodpsn, GPR4_orph, GPR4_orph, GPR4_orph, GPR4_orph, GPR4_orph, GPR4_orph, GPR4_orph that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MASLRGSETMCNITTSCNVDSNIDQFFQPTLYIIVIVLGFPTNCMALWAAYMQVKQKNELGIYLMNLSIADLLYITTLPLWIDYFVHHDNWIHGQVSCKLFGFIFYTNIYVSIAFLCCISVDRYLAVAHPLKFAKVRRVKTALLVSAIVWLTEIVANSAPLFHDELFQDRFNHTFCFEKYPMEPWVAGMNLYRTFLGFLAPWGIMLAAYRGILRAVRGNVSTERQEKAKIKRLALSLILIVLLCFAPYHVLLLWRSVLFLINPCDCGGEENLFGAYHVTLALTSLNCVADPILYCFVNEGARHDVGRALATLLGLFQRGKSPETLMGASITVETPLAVKKPDFYSEVKTNAYKNDIEVLKDECLQMTILSVKK" }, { "InterPro": [ { "InterPro-ID": "IPR016461", "InterPro-Name": "COMT-like", "InterPro-Type": "FAMILY", "Beg": 1, "End": 350 }, { "InterPro-ID": "IPR036388", "InterPro-Name": "WH-like_DNA-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 2, "End": 99 }, { "InterPro-ID": "IPR016461", "InterPro-Name": "COMT-like", "InterPro-Type": "FAMILY", "Beg": 20, "End": 350 }, { "InterPro-ID": "IPR036390", "InterPro-Name": "WH_DNA-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 9, "End": 104 }, { "InterPro-ID": "IPR001077", "InterPro-Name": "O_MeTrfase_dom", "InterPro-Type": "DOMAIN", "Beg": 123, "End": 332 }, { "InterPro-ID": "IPR012967", "InterPro-Name": "Plant_O-MeTrfase_dimerisation", "InterPro-Type": "DOMAIN", "Beg": 13, "End": 101 }, { "InterPro-ID": "IPR016461", "InterPro-Name": "COMT-like", "InterPro-Type": "FAMILY", "Beg": 13, "End": 335 }, { "InterPro-ID": "IPR029063", "InterPro-Name": "SAM-dependent_MTases_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 101, "End": 350 }, { "InterPro-ID": "IPR029063", "InterPro-Name": "SAM-dependent_MTases_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 103, "End": 347 } ], "response#1": "METVQSSSSAELLRAQTHFSTQLFSFQNYASLKCALHLGIPDAIKQHGKPMNLSELTSALPIKPSKAPYIHRLMRMLVKAGYFAQENECFDLTPIGLLLLKDDPINIRALVLLELHPALLLPWIALSEWFQNDDATPFVTAHGKSFWDYTSRDPEFRKLFDEAMAGDSELISKVLVTEFKYVFEGLKSLVDVGGGNGTLARSIAKAFPNLKCTVFDLPEAVANEQGDGNLDFVAGDMFDRVPSADAILLKIVLHDWSDENCVKILKNCRKSIPVKDKGGKVIIIEGVVELEKNAGNEYAGLENLDMEMLVLYNSKERTKKEWAKLFSDAGFSDYKFIPALDSWCIIELTP", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more O_MeTrfase_dom, Plant_O-MeTrfase_dimerisation that are essential for its biological function; 2. The protein should belong to COMT-like, COMT-like, COMT-like that shares evolutionary origin and functional similarity; 3. The protein should be classified within WH-like_DNA-bd_sf, WH_DNA-bd_sf, SAM-dependent_MTases_sf, SAM-dependent_MTases_sf sharing conserved structural features. The designed protein sequence is ", "reference": "METVQSSSSAELLRAQTHFSTQLFSFQNYASLKCALHLGIPDAIKQHGKPMNLSELTSALPIKPSKAPYIHRLMRMLVKAGYFAQENECFDLTPIGLLLLKDDPINIRALVLLELHPALLLPWIALSEWFQNDDATPFVTAHGKSFWDYTSRDPEFRKLFDEAMAGDSELISKVLVTEFKYVFEGLKSLVDVGGGNGTLARSIAKAFPNLKCTVFDLPEAVANEQGDGNLDFVAGDMFDRVPSADAILLKIVLHDWSDENCVKILKNCRKSIPVKDKGGKVIIIEGVVELEKNAGNEYAGLENLDMEMLVLYNSKERTKKEWAKLFSDAGFSDYKFIPALDSWCIIELTP" }, { "InterPro": [ { "InterPro-ID": "IPR009449", "InterPro-Name": "Sec2_N", "InterPro-Type": "DOMAIN", "Beg": 201, "End": 288 }, { "InterPro-ID": "IPR040351", "InterPro-Name": "RAB3IL/RAB3IP/Sec2", "InterPro-Type": "FAMILY", "Beg": 85, "End": 571 } ], "response#1": "MCPLPHANLSMVTNEVTNFMSSLIAFQTYHLRHSFLSPSNMIPRSSNHKRSLSSGPRSLSPDRTVTKTKSTNDLAATATEKPSLATRSNSAGDIPDSGFSTLRDPRLVNNSEASDTSSTPSHHPDLSSEVAALSVKLIQAINNQTTLDDNLVATRQELEQAQNRIKSLESENEKYRHDIEQAVLIKKADADREISQLKAALAEEKAQRAIVEKSKKTIEQELETLTAALFEEANKMVAAAKLEREAVEKKNEQLRAQVKDTELLLASHQEQLAELKSVMQGMNIAKDDVEVRTTISTVPSSPDGHQQLPGIFPRSLETADPPEQSPHVEEIVPGPSTSFPHLFKSVCRTDIQAFEDFRELFSLSSASKPPSRAASGSYAGLNVMSLANFSSAGFGSASSSPAKSTHSPNGSMSSPQPATSHIPLKETRFYKRVLMEDIEPTLRLDAAPGISWLTRRAVLSSICEGSLVVEPIPPATRKYGFPCSLCGDRRPGSANERTHRFRTSDSDTAQRYPLCVLCLEKVRSSCEFTGYLRLILDGHVRAADAEEEKDAWEETVRLRERMFWSRIGGGVVPTFAQANSFENAGSAPSRHNLGDRIGDDEQDRLDAPLETYETPNHGHDHGVSDSDYDNASVSGYTSASGVSRPFYGSPKSHASEKGKDEYLEHGVSQVTLSATSDDPKSITHVEESLVIRTAKNDDGHDDDQN", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Sec2_N that are essential for its biological function; 2. The protein should belong to RAB3IL/RAB3IP/Sec2 that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MCPLPHANLSMVTNEVTNFMSSLIAFQTYHLRHSFLSPSNMIPRSSNHKRSLSSGPRSLSPDRTVTKTKSTNDLAATATEKPSLATRSNSAGDIPDSGFSTLRDPRLVNNSEASDTSSTPSHHPDLSSEVAALSVKLIQAINNQTTLDDNLVATRQELEQAQNRIKSLESENEKYRHDIEQAVLIKKADADREISQLKAALAEEKAQRAIVEKSKKTIEQELETLTAALFEEANKMVAAAKLEREAVEKKNEQLRAQVKDTELLLASHQEQLAELKSVMQGMNIAKDDVEVRTTISTVPSSPDGHQQLPGIFPRSLETADPPEQSPHVEEIVPGPSTSFPHLFKSVCRTDIQAFEDFRELFSLSSASKPPSRAASGSYAGLNVMSLANFSSAGFGSASSSPAKSTHSPNGSMSSPQPATSHIPLKETRFYKRVLMEDIEPTLRLDAAPGISWLTRRAVLSSICEGSLVVEPIPPATRKYGFPCSLCGDRRPGSANERTHRFRTSDSDTAQRYPLCVLCLEKVRSSCEFTGYLRLILDGHVRAADAEEEKDAWEETVRLRERMFWSRIGGGVVPTFAQANSFENAGSAPSRHNLGDRIGDDEQDRLDAPLETYETPNHGHDHGVSDSDYDNASVSGYTSASGVSRPFYGSPKSHASEKGKDEYLEHGVSQVTLSATSDDPKSITHVEESLVIRTAKNDDGHDDDQN" }, { "InterPro": [ { "InterPro-ID": "IPR023098", "InterPro-Name": "SerK/SbnI_C", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 83, "End": 187 }, { "InterPro-ID": "IPR003115", "InterPro-Name": "ParB/Sulfiredoxin_dom", "InterPro-Type": "DOMAIN", "Beg": 8, "End": 78 }, { "InterPro-ID": "IPR003115", "InterPro-Name": "ParB/Sulfiredoxin_dom", "InterPro-Type": "DOMAIN", "Beg": 7, "End": 91 }, { "InterPro-ID": "IPR036086", "InterPro-Name": "ParB/Sulfiredoxin_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 5, "End": 197 } ], "response#1": "MSNYQLEWVSPKQLRPHEDVILSIVNENIEILRKDNSMAPIIVDKNSMVILDGHHRYYASLSLGLPKIPAIMIDYNSEQVEVREWNRIIAPDSSIRDFLRVFRSSVDGKYCVSYKSDVVFCDDNIYSLYWKEEAIEQLLSRMGYNVVKTADQEATISIPPVPKNVVIDFSYKGLRFPPKSTRHIYHFYIPKQRIILQWD", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more ParB/Sulfiredoxin_dom, ParB/Sulfiredoxin_dom that are essential for its biological function; 2. The protein should be classified within SerK/SbnI_C, ParB/Sulfiredoxin_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MSNYQLEWVSPKQLRPHEDVILSIVNENIEILRKDNSMAPIIVDKNSMVILDGHHRYYASLSLGLPKIPAIMIDYNSEQVEVREWNRIIAPDSSIRDFLRVFRSSVDGKYCVSYKSDVVFCDDNIYSLYWKEEAIEQLLSRMGYNVVKTADQEATISIPPVPKNVVIDFSYKGLRFPPKSTRHIYHFYIPKQRIILQWD" }, { "InterPro": [ { "InterPro-ID": "IPR050321", "InterPro-Name": "Glycosyltr_2/OpgH_subfam", "InterPro-Type": "FAMILY", "Beg": 12, "End": 445 }, { "InterPro-ID": "IPR029044", "InterPro-Name": "Nucleotide-diphossugar_trans", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 36, "End": 253 }, { "InterPro-ID": "IPR001173", "InterPro-Name": "Glyco_trans_2-like", "InterPro-Type": "DOMAIN", "Beg": 49, "End": 220 }, { "InterPro-ID": "IPR029044", "InterPro-Name": "Nucleotide-diphossugar_trans", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 40, "End": 307 } ], "response#1": "MGLTDIFLNLLLFVYPAVFIIYQIILYEISARKQINQEALKYSNLPVLSIIVPIKNEEISVIQGLLDNLSNLIWDKKKLEIIIVSDDNEDYFTKIINTVKVPKDLTVYFYRREKKLGYKSGALQYGFEKATGDLILTIDVDSRLPPNALINAYEKMQSNTCDAIVFQWNGYSSNQYSTLAKGMVVSTLFASKALFEGKEKLKLKIYPVGSGTMFSREALRVVNGWDYRLVQDDLEIGTRLIYNGKNVCASGIPIYVEVPDNFYSFYVQQTRWAMGSAEVLRNRLKYIIKSKISFTQRMDLIIYLLQYTPVIVTFFISTLLSLMLPFRIGHDPLNSPALLFWLVSLGLYASLLLSLALKLGLNLKDSLMGIGRLTAFTVSISPFIVFNFFKGLLKSGNTYVITPKGTVKKTNKLLRIIAIIGVFGLLYLLSSILYIYEGYYVTGIWLLYYSSAYLYTMLLYYKEL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Glyco_trans_2-like that are essential for its biological function; 2. The protein should belong to Glycosyltr_2/OpgH_subfam that shares evolutionary origin and functional similarity; 3. The protein should be classified within Nucleotide-diphossugar_trans, Nucleotide-diphossugar_trans sharing conserved structural features. The designed protein sequence is ", "reference": "MGLTDIFLNLLLFVYPAVFIIYQIILYEISARKQINQEALKYSNLPVLSIIVPIKNEEISVIQGLLDNLSNLIWDKKKLEIIIVSDDNEDYFTKIINTVKVPKDLTVYFYRREKKLGYKSGALQYGFEKATGDLILTIDVDSRLPPNALINAYEKMQSNTCDAIVFQWNGYSSNQYSTLAKGMVVSTLFASKALFEGKEKLKLKIYPVGSGTMFSREALRVVNGWDYRLVQDDLEIGTRLIYNGKNVCASGIPIYVEVPDNFYSFYVQQTRWAMGSAEVLRNRLKYIIKSKISFTQRMDLIIYLLQYTPVIVTFFISTLLSLMLPFRIGHDPLNSPALLFWLVSLGLYASLLLSLALKLGLNLKDSLMGIGRLTAFTVSISPFIVFNFFKGLLKSGNTYVITPKGTVKKTNKLLRIIAIIGVFGLLYLLSSILYIYEGYYVTGIWLLYYSSAYLYTMLLYYKEL" }, { "InterPro": [ { "InterPro-ID": "IPR035937", "InterPro-Name": "MutM-like_N-ter", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 2, "End": 119 }, { "InterPro-ID": "IPR044090", "InterPro-Name": "Nei2_N", "InterPro-Type": "DOMAIN", "Beg": 1, "End": 108 }, { "InterPro-ID": "IPR010663", "InterPro-Name": "Znf_FPG/IleRS", "InterPro-Type": "DOMAIN", "Beg": 222, "End": 250 }, { "InterPro-ID": "IPR015887", "InterPro-Name": "DNA_glyclase_Znf_dom_DNA_BS", "InterPro-Type": "BINDING_SITE", "Beg": 225, "End": 249 }, { "InterPro-ID": "IPR015886", "InterPro-Name": "DNA_glyclase/AP_lyase_DNA-bd", "InterPro-Type": "DOMAIN", "Beg": 118, "End": 206 }, { "InterPro-ID": "IPR012319", "InterPro-Name": "FPG_cat", "InterPro-Type": "DOMAIN", "Beg": 2, "End": 104 }, { "InterPro-ID": "IPR010979", "InterPro-Name": "Ribosomal_uS13-like_H2TH", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 118, "End": 182 }, { "InterPro-ID": "IPR012319", "InterPro-Name": "FPG_cat", "InterPro-Type": "DOMAIN", "Beg": 2, "End": 97 }, { "InterPro-ID": "IPR054878", "InterPro-Name": "Endonuc_Nei2", "InterPro-Type": "FAMILY", "Beg": 1, "End": 249 }, { "InterPro-ID": "IPR012319", "InterPro-Name": "FPG_cat", "InterPro-Type": "DOMAIN", "Beg": 1, "End": 94 }, { "InterPro-ID": "IPR035937", "InterPro-Name": "MutM-like_N-ter", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 2, "End": 118 }, { "InterPro-ID": "IPR000214", "InterPro-Name": "Znf_DNA_glyclase/AP_lyase", "InterPro-Type": "DOMAIN", "Beg": 216, "End": 250 } ], "response#1": "MPEGDTVFHTAAALRAALEGKTLTRCDVRVPRYATVDLSGAVVDEVLSRGKHLFIRAGSASIHSHLKMEGAWRIGHTKVAPHRIRIVLETADTRAIGIDLGILEVLDRGTDMDAVAYLGPDLLGPDWEPRVAADNLAADPDRPLAQALLDQRVMAGVGNVYCNELCFVFGRLPTAPVGTLKDPLRVVQRARDMLWLNRSRWNRTTTGDTRNGRQLWVYGRAGEPCRRCGTLIQTDRGGERVTYWCPVCQTAS", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Nei2_N, Znf_FPG/IleRS, DNA_glyclase/AP_lyase_DNA-bd, FPG_cat, FPG_cat, FPG_cat, Znf_DNA_glyclase/AP_lyase that are essential for its biological function; 2. The protein should belong to Endonuc_Nei2 that shares evolutionary origin and functional similarity; 3. The protein should be classified within MutM-like_N-ter, Ribosomal_uS13-like_H2TH, MutM-like_N-ter sharing conserved structural features; 4. The protein should include a DNA_glyclase_Znf_dom_DNA_BS that enables ligand binding under diverse conditions. The designed protein sequence is ", "reference": "MPEGDTVFHTAAALRAALEGKTLTRCDVRVPRYATVDLSGAVVDEVLSRGKHLFIRAGSASIHSHLKMEGAWRIGHTKVAPHRIRIVLETADTRAIGIDLGILEVLDRGTDMDAVAYLGPDLLGPDWEPRVAADNLAADPDRPLAQALLDQRVMAGVGNVYCNELCFVFGRLPTAPVGTLKDPLRVVQRARDMLWLNRSRWNRTTTGDTRNGRQLWVYGRAGEPCRRCGTLIQTDRGGERVTYWCPVCQTAS" }, { "InterPro": [ { "InterPro-ID": "IPR023753", "InterPro-Name": "FAD/NAD-binding_dom", "InterPro-Type": "DOMAIN", "Beg": 28, "End": 244 }, { "InterPro-ID": "IPR036188", "InterPro-Name": "FAD/NAD-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 84, "End": 258 } ], "response#1": "MLVSDRDKLEDKALIPLDNIFHNGKGTLVQASVTSVEKEKTGGFVVLDNGEKLPFYVLVVATGSKWSGPVDFPSKPEDVTKWISEQRKKFKDAKNIVIAGGGSVGLELSGEIKDIWPEKSVTIVHSQKKLLNSVYPDKFRDRAAQAYRPRTKLVLDDQIPGELTPGATSVTTRNGKTITADLIVPAWGNKPNTALLSSLKDVLSPNGCVKIRDTFQTQAYPDIFALGDIIDVNEQKQAGKAQAHAGMVAANVLSYVQGQPLKQKYKGSYELIVITNGKNDGVGYFGVWWGIVIGGWLASLLKAKDLMLPATRVATGASK", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more FAD/NAD-binding_dom that are essential for its biological function; 2. The protein should be classified within FAD/NAD-bd_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MLVSDRDKLEDKALIPLDNIFHNGKGTLVQASVTSVEKEKTGGFVVLDNGEKLPFYVLVVATGSKWSGPVDFPSKPEDVTKWISEQRKKFKDAKNIVIAGGGSVGLELSGEIKDIWPEKSVTIVHSQKKLLNSVYPDKFRDRAAQAYRPRTKLVLDDQIPGELTPGATSVTTRNGKTITADLIVPAWGNKPNTALLSSLKDVLSPNGCVKIRDTFQTQAYPDIFALGDIIDVNEQKQAGKAQAHAGMVAANVLSYVQGQPLKQKYKGSYELIVITNGKNDGVGYFGVWWGIVIGGWLASLLKAKDLMLPATRVATGASK" }, { "InterPro": [ { "InterPro-ID": "IPR036396", "InterPro-Name": "Cyt_P450_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 34, "End": 495 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 37, "End": 469 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 307, "End": 324 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 363, "End": 374 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 435, "End": 444 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 444, "End": 455 }, { "InterPro-ID": "IPR017972", "InterPro-Name": "Cyt_P450_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 437, "End": 446 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 402, "End": 426 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 316, "End": 342 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 434, "End": 444 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 296, "End": 313 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 444, "End": 467 }, { "InterPro-ID": "IPR036396", "InterPro-Name": "Cyt_P450_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 27, "End": 494 } ], "response#1": "MELITLLSALLVLAIVSLSTFFVLYYNTPTKDGKTLPPGRMGWPFIGESYDFFAAGWKGKPESFIFDRLKKFAKGNLNGQFRTSLFGNKSIVVAGAAANKLLFSNEKKLVTMWWPPSIDKAFPSTAQLSANEEALLMRKFFPSFLIRREALQRYIPIMDDCTRRHFATGAWGPSDKIEAFNVTQDYTFWVACRVFMSIDAQEDPETVDSLFRHFNVLKAGIYSMHIDLPWTNFHHAMKASHAIRSAVEQIAKKRRAELAEGKAFPTQDMLSYMLETPITSAEDSKDGKAKYLNDADIGTKILGLLVGGHDTSSTVIAFFFKFMAENPHVYEAIYKEQMEVAATKAPGELLNWDDLQKMKYSWCAICEVMRLTPPVQGAFRQAITDFTHNGYLIPKGWKIYWSTHSTHRNPEIFPQPEKFDPTRFEGNGPPAFSFVPFGGGPRMCPGKEYARLQVLTFVHHIVTKFKWEQILPNEKIIVSPMPYPEKNLPLRMIARSESATLA", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Cyt_P450, Cyt_P450, Cyt_P450, Cyt_P450, Cyt_P450, Cyt_P450_E_grp-I, Cyt_P450_E_grp-I, Cyt_P450_E_grp-I, Cyt_P450_E_grp-I, Cyt_P450_E_grp-I that shares evolutionary origin and functional similarity; 2. The protein should be classified within Cyt_P450_sf, Cyt_P450_sf sharing conserved structural features; 3. The protein should contain Cyt_P450_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MELITLLSALLVLAIVSLSTFFVLYYNTPTKDGKTLPPGRMGWPFIGESYDFFAAGWKGKPESFIFDRLKKFAKGNLNGQFRTSLFGNKSIVVAGAAANKLLFSNEKKLVTMWWPPSIDKAFPSTAQLSANEEALLMRKFFPSFLIRREALQRYIPIMDDCTRRHFATGAWGPSDKIEAFNVTQDYTFWVACRVFMSIDAQEDPETVDSLFRHFNVLKAGIYSMHIDLPWTNFHHAMKASHAIRSAVEQIAKKRRAELAEGKAFPTQDMLSYMLETPITSAEDSKDGKAKYLNDADIGTKILGLLVGGHDTSSTVIAFFFKFMAENPHVYEAIYKEQMEVAATKAPGELLNWDDLQKMKYSWCAICEVMRLTPPVQGAFRQAITDFTHNGYLIPKGWKIYWSTHSTHRNPEIFPQPEKFDPTRFEGNGPPAFSFVPFGGGPRMCPGKEYARLQVLTFVHHIVTKFKWEQILPNEKIIVSPMPYPEKNLPLRMIARSESATLA" }, { "InterPro": [ { "InterPro-ID": "IPR041555", "InterPro-Name": "MG3", "InterPro-Type": "DOMAIN", "Beg": 233, "End": 319 }, { "InterPro-ID": "IPR018081", "InterPro-Name": "Anaphylatoxin_comp_syst", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 681, "End": 749 }, { "InterPro-ID": "IPR009048", "InterPro-Name": "A-macroglobulin_rcpt-bd", "InterPro-Type": "DOMAIN", "Beg": 1471, "End": 1560 }, { "InterPro-ID": "IPR000020", "InterPro-Name": "Anaphylatoxin/fibulin", "InterPro-Type": "DOMAIN", "Beg": 700, "End": 734 }, { "InterPro-ID": "IPR008993", "InterPro-Name": "TIMP-like_OB-fold", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1579, "End": 1732 }, { "InterPro-ID": "IPR013783", "InterPro-Name": "Ig-like_fold", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 364, "End": 464 }, { "InterPro-ID": "IPR008930", "InterPro-Name": "Terpenoid_cyclase/PrenylTrfase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 989, "End": 1309 }, { "InterPro-ID": "IPR002890", "InterPro-Name": "MG2", "InterPro-Type": "DOMAIN", "Beg": 139, "End": 231 }, { "InterPro-ID": "IPR018933", "InterPro-Name": "Netrin_module_non-TIMP", "InterPro-Type": "DOMAIN", "Beg": 1606, "End": 1714 }, { "InterPro-ID": "IPR036595", "InterPro-Name": "A-macroglobulin_rcpt-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1450, "End": 1580 }, { "InterPro-ID": "IPR011625", "InterPro-Name": "A2M_N_BRD", "InterPro-Type": "DOMAIN", "Beg": 475, "End": 608 }, { "InterPro-ID": "IPR036595", "InterPro-Name": "A-macroglobulin_rcpt-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1444, "End": 1577 }, { "InterPro-ID": "IPR001134", "InterPro-Name": "Netrin_domain", "InterPro-Type": "DOMAIN", "Beg": 1585, "End": 1732 }, { "InterPro-ID": "IPR000020", "InterPro-Name": "Anaphylatoxin/fibulin", "InterPro-Type": "DOMAIN", "Beg": 684, "End": 752 }, { "InterPro-ID": "IPR018933", "InterPro-Name": "Netrin_module_non-TIMP", "InterPro-Type": "DOMAIN", "Beg": 1604, "End": 1716 }, { "InterPro-ID": "IPR047565", "InterPro-Name": "Alpha-macroglob_thiol-ester_cl", "InterPro-Type": "CONSERVED_SITE", "Beg": 992, "End": 1020 }, { "InterPro-ID": "IPR001599", "InterPro-Name": "Macroglobln_a2", "InterPro-Type": "DOMAIN", "Beg": 776, "End": 864 }, { "InterPro-ID": "IPR011625", "InterPro-Name": "A2M_N_BRD", "InterPro-Type": "DOMAIN", "Beg": 470, "End": 609 }, { "InterPro-ID": "IPR011626", "InterPro-Name": "Alpha-macroglobulin_TED", "InterPro-Type": "DOMAIN", "Beg": 977, "End": 1307 }, { "InterPro-ID": "IPR001840", "InterPro-Name": "Anaphylatoxn_comp_syst_dom", "InterPro-Type": "DOMAIN", "Beg": 725, "End": 736 }, { "InterPro-ID": "IPR001840", "InterPro-Name": "Anaphylatoxn_comp_syst_dom", "InterPro-Type": "DOMAIN", "Beg": 713, "End": 724 }, { "InterPro-ID": "IPR001840", "InterPro-Name": "Anaphylatoxn_comp_syst_dom", "InterPro-Type": "DOMAIN", "Beg": 696, "End": 705 }, { "InterPro-ID": "IPR008993", "InterPro-Name": "TIMP-like_OB-fold", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1578, "End": 1734 }, { "InterPro-ID": "IPR013783", "InterPro-Name": "Ig-like_fold", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 826, "End": 929 }, { "InterPro-ID": "IPR050473", "InterPro-Name": "A2M/Complement_sys", "InterPro-Type": "FAMILY", "Beg": 11, "End": 1588 }, { "InterPro-ID": "IPR048847", "InterPro-Name": "C4_MG1", "InterPro-Type": "DOMAIN", "Beg": 23, "End": 132 }, { "InterPro-ID": "IPR054587", "InterPro-Name": "CO4A-B_CUB_C", "InterPro-Type": "DOMAIN", "Beg": 1312, "End": 1378 } ], "response#1": "MRLLWGLAWVFSFCASSLQKPRLLLFSPSVVNLGTPLSVGVQLLDAPPGQEVKGSVFLRNPKGGSCSPKKDFKLSSGDDFVLLSLEVPLEDVRSCGLFDLRRAPYIQLVAQSPWLRNTAFKATETQGVNLLYSSRRGHIFVQTDQPIYNPGQRVRYRVFALDQKMRPSTDFLTITVENSHGLRVLKKEIFTSTSILQDTFTIPDISEPGTWKISARFSDGLESNRSTHFEVKKYVLPNFEVKITPWKPYILMVPSNSDEIQLDIQARYIYGKPVQGVAYTRFALMDEQGKRTFLRGLETQAKLVEGRTHISISKDQFQAALDKINIGVRDLEGLRLYAATAVIESPGGEMEEAELTSWRFVSSAFSLDLSRTKRHLVPGAHFLLQALVREISGSEASNVIVKVSPTLVSGSDSQVLNVQQSTNRIGQVSISFPIPPTVTGLRLLVSAGSLYPMIARLTVQSPPSRGTGFLSIEPLDPRSPRVGDTFILNLQAVGIPAPTFSHYYYMIISRGQIMAMSREARRTVTSVSVLVDHQLAPSFYFVAYFYHQGHPVANSLLINIQPRDCEGKLQLKVVGAKEYHNGDMMKLRIQTDSKALVALGAVDTALYAVGGWSHKPLDMSKVFEVINSYNVGCGPGGGDDAPQVFQDAGLAFSDGDRLTQTREDLSCPKEKKSRQKRNVNFLKALSEKLGQYSSPDAKRCCQDGMTKLPMKRTCEQRAARVPQQACREPFLSCCKFAEDLRRNQTRSQAPLARKVRDMVNLIEEDDILVRTSFPENWLWRVEPVDSSKLLTVRLPDSMTTWEIHGVSLSKSKGLCVAKPTRVRVFRKFHLHLRLPISVRRFEQLELRPVLYNYLNDDKNVSVHVTPVEGLCMAGGGMMAQWVIVPAGSALPVAFSVVPTASTNVPLKLVAKGTLDSSDSVSKILQIEKEGAIHREEIVYNLDPLNNLGQMLEIPGSSDPNIVPEGDFSTFVKVTASEPLETLGSEEALSPGGVASLLRLPGCAEQTMIYLAPTLTASNYLDRTKQWSKLSPETKDHAVHLIQKGHVRIQQFRKKDGSFGAWLHRDSSTWLTAFVLKILSLAQEQVGNSPEKLQETASWLLAQQLGDGSFHDPCPVIHRAMQGGLVGSNETVALTAFVVIALHHGLNVFREGHAKQLKNRVEASITKANSFLGQKASAGLLGAHAAAITAYALTLTKASEDLRNVAHNSLMAMAEETGENLYWGLVLGSQDKVVLRPADPRSPTEPVPQAPALWIETTAYALLHLLLREGKGKMADKAASWLTHQGNFHGAFRSTQDTVVTLDALSAYWIASHTTEEKALKVTLSSMGRNGLKTHVLHLNNHQVKGLEEELKFSLGSTISVKVEGNSKGTLKILRTYNVLDMKNTTCQDLQIEVKVTDAVEYAWSAYEDYEDDYNMPATDDPSVPLQPVTPLQLFEGRRSRRRREAPKVAEERESRVHYTVCIWRNGKLGLSGMAIADITLLSGFHALRADLEKLTSLSDRYVSHFETDGPHVLLYFDSVPTTRECVGFGASQEVVVGLVQPASAVLYDYYSPDHKCSVFYAAPTKSQLLATLCSGDVCQCAEGKCPRLLRSLERRVEDKDGYRMRFACYYHQVEYGFTVKVLREDGRAAFRFFESKITQVLHFRTDTMASIGQTRNFLSRTSCRLRLEPNKEYLIMGMDGETSDNKGDPQYLLDSNTWIEEMPSEQMCKSTRHRAACFQLKDFLMEFSSRGCQV", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more MG3, A-macroglobulin_rcpt-bd, Anaphylatoxin/fibulin, MG2, Netrin_module_non-TIMP, A2M_N_BRD, Netrin_domain, Anaphylatoxin/fibulin, Netrin_module_non-TIMP, Macroglobln_a2, A2M_N_BRD, Alpha-macroglobulin_TED, Anaphylatoxn_comp_syst_dom, Anaphylatoxn_comp_syst_dom, Anaphylatoxn_comp_syst_dom, C4_MG1, CO4A-B_CUB_C that are essential for its biological function; 2. The protein should belong to A2M/Complement_sys that shares evolutionary origin and functional similarity; 3. The protein should be classified within Anaphylatoxin_comp_syst, TIMP-like_OB-fold, Ig-like_fold, Terpenoid_cyclase/PrenylTrfase, A-macroglobulin_rcpt-bd_sf, A-macroglobulin_rcpt-bd_sf, TIMP-like_OB-fold, Ig-like_fold sharing conserved structural features; 4. The protein should contain Alpha-macroglob_thiol-ester_cl that is preserved across related proteins. The designed protein sequence is ", "reference": "MRLLWGLAWVFSFCASSLQKPRLLLFSPSVVNLGTPLSVGVQLLDAPPGQEVKGSVFLRNPKGGSCSPKKDFKLSSGDDFVLLSLEVPLEDVRSCGLFDLRRAPYIQLVAQSPWLRNTAFKATETQGVNLLYSSRRGHIFVQTDQPIYNPGQRVRYRVFALDQKMRPSTDFLTITVENSHGLRVLKKEIFTSTSILQDTFTIPDISEPGTWKISARFSDGLESNRSTHFEVKKYVLPNFEVKITPWKPYILMVPSNSDEIQLDIQARYIYGKPVQGVAYTRFALMDEQGKRTFLRGLETQAKLVEGRTHISISKDQFQAALDKINIGVRDLEGLRLYAATAVIESPGGEMEEAELTSWRFVSSAFSLDLSRTKRHLVPGAHFLLQALVREISGSEASNVIVKVSPTLVSGSDSQVLNVQQSTNRIGQVSISFPIPPTVTGLRLLVSAGSLYPMIARLTVQSPPSRGTGFLSIEPLDPRSPRVGDTFILNLQAVGIPAPTFSHYYYMIISRGQIMAMSREARRTVTSVSVLVDHQLAPSFYFVAYFYHQGHPVANSLLINIQPRDCEGKLQLKVVGAKEYHNGDMMKLRIQTDSKALVALGAVDTALYAVGGWSHKPLDMSKVFEVINSYNVGCGPGGGDDAPQVFQDAGLAFSDGDRLTQTREDLSCPKEKKSRQKRNVNFLKALSEKLGQYSSPDAKRCCQDGMTKLPMKRTCEQRAARVPQQACREPFLSCCKFAEDLRRNQTRSQAPLARKVRDMVNLIEEDDILVRTSFPENWLWRVEPVDSSKLLTVRLPDSMTTWEIHGVSLSKSKGLCVAKPTRVRVFRKFHLHLRLPISVRRFEQLELRPVLYNYLNDDKNVSVHVTPVEGLCMAGGGMMAQWVIVPAGSALPVAFSVVPTASTNVPLKLVAKGTLDSSDSVSKILQIEKEGAIHREEIVYNLDPLNNLGQMLEIPGSSDPNIVPEGDFSTFVKVTASEPLETLGSEEALSPGGVASLLRLPGCAEQTMIYLAPTLTASNYLDRTKQWSKLSPETKDHAVHLIQKGHVRIQQFRKKDGSFGAWLHRDSSTWLTAFVLKILSLAQEQVGNSPEKLQETASWLLAQQLGDGSFHDPCPVIHRAMQGGLVGSNETVALTAFVVIALHHGLNVFREGHAKQLKNRVEASITKANSFLGQKASAGLLGAHAAAITAYALTLTKASEDLRNVAHNSLMAMAEETGENLYWGLVLGSQDKVVLRPADPRSPTEPVPQAPALWIETTAYALLHLLLREGKGKMADKAASWLTHQGNFHGAFRSTQDTVVTLDALSAYWIASHTTEEKALKVTLSSMGRNGLKTHVLHLNNHQVKGLEEELKFSLGSTISVKVEGNSKGTLKILRTYNVLDMKNTTCQDLQIEVKVTDAVEYAWSAYEDYEDDYNMPATDDPSVPLQPVTPLQLFEGRRSRRRREAPKVAEERESRVHYTVCIWRNGKLGLSGMAIADITLLSGFHALRADLEKLTSLSDRYVSHFETDGPHVLLYFDSVPTTRECVGFGASQEVVVGLVQPASAVLYDYYSPDHKCSVFYAAPTKSQLLATLCSGDVCQCAEGKCPRLLRSLERRVEDKDGYRMRFACYYHQVEYGFTVKVLREDGRAAFRFFESKITQVLHFRTDTMASIGQTRNFLSRTSCRLRLEPNKEYLIMGMDGETSDNKGDPQYLLDSNTWIEEMPSEQMCKSTRHRAACFQLKDFLMEFSSRGCQV" }, { "InterPro": [ { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 750, "End": 822 }, { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 750, "End": 825 } ], "response#1": "MKYLQFLAAVAAVSAFSGPVLAGSSVENTNQVLPVQLTGALFSQVANGQHAERAIKVDNSAQFVPVQGTIAALSAVLNEQKAGKRSFSVENTNQVLPIDVIIAGLSQVLTEQKAAKRDNIVKNTNQILPIEATIAALSAIANGQKAATKRSTAVDNSSQFIPIQGTLAAFSNVLNSQKATKRNTGKVVDNTNQVVPIQGTLAALSTVLNEQKASKRGVDVDNSSQTLPIEATIAALSTIANGQQAGKRNAPDFDVVKNSNQVLPIQATAALLSQIANGQSVEKRNAPDFDVVKNSNQVLPIQATAALLSQIANGQSVEKRNAPDFDVVKNSNQVLPIQATAALLSQIANGQSVEKRNAPDFDVVKNSNQVLPIQATAALLSQIANGQSVEKRNAPDFDSVKNSNQVVPIQATAALLSAVKNLQSVERNAPDFDSVKNSNQVVPIQATAALLSQIANGQSVEKRNAPDFDSVKNSNQVVPIQGTAALLSVVGNGQSVSKRHEGENNIVDNTNQVIPIQATIAALSTLLNSQKAERSYSVDNTNQVLPIEATLAAFSSVLNSQKAERSYSVENDNEVVPVDLVAAALSQVANGQKVTRRGETKESIKHNVNQVAPAQASLSALSDIVNSAHSRRAMDVKQYETLQYAINALQQALDKTNTGDKTHHVDAMTGTAEHFDERDAGLDPAAFLGSAASGISVPVGNKDLLKSLVKRYAAEEDEAMAKRTPSLNGRGQRPRPRNSSSSEHNNNGQCSVGEAKCCSQVITDEGKKKTLAGLLGFNNLVGDIGLNCQQIPVLGVSLQSICKATPVCCTNVSQDGLVNVGCTSIPIN", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Hydrophobin, Hydrophobin that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MKYLQFLAAVAAVSAFSGPVLAGSSVENTNQVLPVQLTGALFSQVANGQHAERAIKVDNSAQFVPVQGTIAALSAVLNEQKAGKRSFSVENTNQVLPIDVIIAGLSQVLTEQKAAKRDNIVKNTNQILPIEATIAALSAIANGQKAATKRSTAVDNSSQFIPIQGTLAAFSNVLNSQKATKRNTGKVVDNTNQVVPIQGTLAALSTVLNEQKASKRGVDVDNSSQTLPIEATIAALSTIANGQQAGKRNAPDFDVVKNSNQVLPIQATAALLSQIANGQSVEKRNAPDFDVVKNSNQVLPIQATAALLSQIANGQSVEKRNAPDFDVVKNSNQVLPIQATAALLSQIANGQSVEKRNAPDFDVVKNSNQVLPIQATAALLSQIANGQSVEKRNAPDFDSVKNSNQVVPIQATAALLSAVKNLQSVERNAPDFDSVKNSNQVVPIQATAALLSQIANGQSVEKRNAPDFDSVKNSNQVVPIQGTAALLSVVGNGQSVSKRHEGENNIVDNTNQVIPIQATIAALSTLLNSQKAERSYSVDNTNQVLPIEATLAAFSSVLNSQKAERSYSVENDNEVVPVDLVAAALSQVANGQKVTRRGETKESIKHNVNQVAPAQASLSALSDIVNSAHSRRAMDVKQYETLQYAINALQQALDKTNTGDKTHHVDAMTGTAEHFDERDAGLDPAAFLGSAASGISVPVGNKDLLKSLVKRYAAEEDEAMAKRTPSLNGRGQRPRPRNSSSSEHNNNGQCSVGEAKCCSQVITDEGKKKTLAGLLGFNNLVGDIGLNCQQIPVLGVSLQSICKATPVCCTNVSQDGLVNVGCTSIPIN" }, { "InterPro": [ { "InterPro-ID": "IPR020843", "InterPro-Name": "PKS_ER", "InterPro-Type": "DOMAIN", "Beg": 24, "End": 352 }, { "InterPro-ID": "IPR013149", "InterPro-Name": "ADH-like_C", "InterPro-Type": "DOMAIN", "Beg": 195, "End": 318 }, { "InterPro-ID": "IPR013154", "InterPro-Name": "ADH-like_N", "InterPro-Type": "DOMAIN", "Beg": 37, "End": 154 }, { "InterPro-ID": "IPR047109", "InterPro-Name": "CAD-like", "InterPro-Type": "FAMILY", "Beg": 16, "End": 353 }, { "InterPro-ID": "IPR036291", "InterPro-Name": "NAD(P)-bd_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 157, "End": 322 }, { "InterPro-ID": "IPR047109", "InterPro-Name": "CAD-like", "InterPro-Type": "FAMILY", "Beg": 9, "End": 357 }, { "InterPro-ID": "IPR011032", "InterPro-Name": "GroES-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 11, "End": 200 } ], "response#1": "MAGKSPEEQHPVKAYGWAATDSSGILSPFKFSRRATGDHDVRVKILYAGVCHSDLQSARNDMGCFTYPLVPGFETVGTATEVGSKVTKVKVGDKVAVGIMVGSCGKCDECVNDRECYCPEVITSYGRIDHDGTPTYGGFSSETVANEKFVFCFPEKLPMAAGAPLLNAGVSVYSAMRFYGLDKPGMHLGVVGLGGLGHLAVKFAKAFGVKVTVISTSTSKKGEAINDLGADAFLVSTDAEQMQAGSGTLDGILDTVPVVHPIEALLGLLKNHTKLVLVGATMGSFELPILPLGVGRKSVVSTIGGSTKETQEMLDFAAEHDITASVEIIPMDYVNTAMERIEKGDVRYRFVIDIGNTLTPPES", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more PKS_ER, ADH-like_C, ADH-like_N that are essential for its biological function; 2. The protein should belong to CAD-like, CAD-like that shares evolutionary origin and functional similarity; 3. The protein should be classified within NAD(P)-bd_dom_sf, GroES-like_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MAGKSPEEQHPVKAYGWAATDSSGILSPFKFSRRATGDHDVRVKILYAGVCHSDLQSARNDMGCFTYPLVPGFETVGTATEVGSKVTKVKVGDKVAVGIMVGSCGKCDECVNDRECYCPEVITSYGRIDHDGTPTYGGFSSETVANEKFVFCFPEKLPMAAGAPLLNAGVSVYSAMRFYGLDKPGMHLGVVGLGGLGHLAVKFAKAFGVKVTVISTSTSKKGEAINDLGADAFLVSTDAEQMQAGSGTLDGILDTVPVVHPIEALLGLLKNHTKLVLVGATMGSFELPILPLGVGRKSVVSTIGGSTKETQEMLDFAAEHDITASVEIIPMDYVNTAMERIEKGDVRYRFVIDIGNTLTPPES" }, { "InterPro": [ { "InterPro-ID": "IPR000917", "InterPro-Name": "Sulfatase_N", "InterPro-Type": "DOMAIN", "Beg": 237, "End": 525 }, { "InterPro-ID": "IPR012549", "InterPro-Name": "EptA-like_N", "InterPro-Type": "DOMAIN", "Beg": 58, "End": 205 }, { "InterPro-ID": "IPR017850", "InterPro-Name": "Alkaline_phosphatase_core_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 234, "End": 527 }, { "InterPro-ID": "IPR040423", "InterPro-Name": "PEA_transferase", "InterPro-Type": "FAMILY", "Beg": 16, "End": 531 }, { "InterPro-ID": "IPR017850", "InterPro-Name": "Alkaline_phosphatase_core_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 215, "End": 538 } ], "response#1": "MTSHHSWYRYSINPFVLMGLVALFLAATANLTFFEKAMAVYPVSDNLGFIISMAVAVMGAMLLIVVLLSYRYVLKPVLILLLIMGAVTSYFTDTYGTVYDTTMLQNAMQTDQAESKDLMNLAFFVRIIGLGVLPSVLVAVAKVNYPTWGKGLIQRAMTWGVSLVLLLVPIGLFSSQYASFFRVHKPVRFYINPITPIYSVGKLASIEYKKATAPTDTIYHAKDAVQTTKPSERKPRLVVFVVGETARADHVQFNGYGRETFPQLAKVDGLANFSQVTSCGTSTAYSVPCMFSYLGQDDYDVDTAKYQENVLDTLDRLGVGILWRDNNSDSKGVMDKLPATQYFDYKSATNNTICNTNPYNECRDVGMLVGLDDYVSANNGKDMLIMLHQMGNHGPAYFKRYDEQFAKFTPVCEGNELAKCEHQSLINAYDNALLATDDFIAKSIDWLKTHEANYDVAMLYVSDHGESLGENGVYLHGMPNAFAPKEQRAVPAFFWSNNTTFKPTASDTVLTHDAITPTLLKLFDVTAGKVKDRAAFIQ", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Sulfatase_N, EptA-like_N that are essential for its biological function; 2. The protein should belong to PEA_transferase that shares evolutionary origin and functional similarity; 3. The protein should be classified within Alkaline_phosphatase_core_sf, Alkaline_phosphatase_core_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MTSHHSWYRYSINPFVLMGLVALFLAATANLTFFEKAMAVYPVSDNLGFIISMAVAVMGAMLLIVVLLSYRYVLKPVLILLLIMGAVTSYFTDTYGTVYDTTMLQNAMQTDQAESKDLMNLAFFVRIIGLGVLPSVLVAVAKVNYPTWGKGLIQRAMTWGVSLVLLLVPIGLFSSQYASFFRVHKPVRFYINPITPIYSVGKLASIEYKKATAPTDTIYHAKDAVQTTKPSERKPRLVVFVVGETARADHVQFNGYGRETFPQLAKVDGLANFSQVTSCGTSTAYSVPCMFSYLGQDDYDVDTAKYQENVLDTLDRLGVGILWRDNNSDSKGVMDKLPATQYFDYKSATNNTICNTNPYNECRDVGMLVGLDDYVSANNGKDMLIMLHQMGNHGPAYFKRYDEQFAKFTPVCEGNELAKCEHQSLINAYDNALLATDDFIAKSIDWLKTHEANYDVAMLYVSDHGESLGENGVYLHGMPNAFAPKEQRAVPAFFWSNNTTFKPTASDTVLTHDAITPTLLKLFDVTAGKVKDRAAFIQ" }, { "InterPro": [ { "InterPro-ID": "IPR005074", "InterPro-Name": "Peptidase_C39", "InterPro-Type": "DOMAIN", "Beg": 352, "End": 474 }, { "InterPro-ID": "IPR025425", "InterPro-Name": "Tox_PAAR-like", "InterPro-Type": "DOMAIN", "Beg": 15, "End": 115 } ], "response#1": "MGNYHIGDGECRFRVVCSSPDVCEVGGYKVPFDSYQTLDSERQYSSTVWARGCRALNVGSVIAGTQSNAGKGVISGTSQGTGDCVILTGSPTVTIEGKPVAYHGSVVGINNHNCLGKLYTKIKSPMISVIDRTFNYERTAEVIHDLLLLKDLLSVGNIFDGDISPEVKNDLFQIKDPDQSWGEFFSIKNIRESLRNGIEGDKSQIREWFGENTLTQMGNGAITTLHGVADLALVTFDALLDTATATVACPIGEDGLCEQANINLNEKEQALFNISNSLINGQAWDALKKMIMDTNNGDQIALEHFASFLWGFMIPAKIPEENISGKVFVEPVVLEGGAGGNWTVFDEVLDSNVIKQLTLTGCGAACGEMLLRDRYIFVTQNVIGTELTSMTSLANKLNKFDVGWEGNAVSESSLYALSNTGSWGAMMWDSGSKVGHWVLVKGVDDAGNVIIYDPYQGSRYLMTEQEFKEVWNGHSVYKP", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Peptidase_C39, Tox_PAAR-like that are essential for its biological function. The designed protein sequence is ", "reference": "MGNYHIGDGECRFRVVCSSPDVCEVGGYKVPFDSYQTLDSERQYSSTVWARGCRALNVGSVIAGTQSNAGKGVISGTSQGTGDCVILTGSPTVTIEGKPVAYHGSVVGINNHNCLGKLYTKIKSPMISVIDRTFNYERTAEVIHDLLLLKDLLSVGNIFDGDISPEVKNDLFQIKDPDQSWGEFFSIKNIRESLRNGIEGDKSQIREWFGENTLTQMGNGAITTLHGVADLALVTFDALLDTATATVACPIGEDGLCEQANINLNEKEQALFNISNSLINGQAWDALKKMIMDTNNGDQIALEHFASFLWGFMIPAKIPEENISGKVFVEPVVLEGGAGGNWTVFDEVLDSNVIKQLTLTGCGAACGEMLLRDRYIFVTQNVIGTELTSMTSLANKLNKFDVGWEGNAVSESSLYALSNTGSWGAMMWDSGSKVGHWVLVKGVDDAGNVIIYDPYQGSRYLMTEQEFKEVWNGHSVYKP" }, { "InterPro": [ { "InterPro-ID": "IPR050651", "InterPro-Name": "Plant_Cytochrome_P450_Monoox", "InterPro-Type": "FAMILY", "Beg": 292, "End": 478 }, { "InterPro-ID": "IPR036396", "InterPro-Name": "Cyt_P450_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 296, "End": 473 }, { "InterPro-ID": "IPR036396", "InterPro-Name": "Cyt_P450_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 25, "End": 295 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 68, "End": 87 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 408, "End": 418 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 92, "End": 113 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 329, "End": 347 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 418, "End": 441 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 286, "End": 312 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 370, "End": 394 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 330, "End": 341 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 418, "End": 429 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 295, "End": 308 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 409, "End": 418 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 39, "End": 297 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 293, "End": 461 }, { "InterPro-ID": "IPR036396", "InterPro-Name": "Cyt_P450_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 38, "End": 472 }, { "InterPro-ID": "IPR017972", "InterPro-Name": "Cyt_P450_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 411, "End": 420 } ], "response#1": "MDLLQILLAIAGLLAILLLQKQWRTKTSPGAKAGRKLPPEPAGAWPVIGHLHKLGGPNPIYRNLAEWSDKYGPVMTLKLGMQNAVVVSDREAIKECFTTNDKALADRPPSSIGLHLGFNYAAIGAAPYGPYWRDMRKLVLLEVLSSRRLEMLRNVRISEIGTSIKELYSNIIRSSGGSGPAKVVISHWIEQLTLNYILRTIAGRRFSDDSSKDAQYVKGVINDFMYFAGQFVVSDVIPIPLLRWLDPQGHLKGMKRVAKEVDTMCEAWIQEHVQRRMREKPGPGQEQDFIDVLLNNRDVMRKAQEEIDNHVGKERWVDETDLKHLVYLQAIVKEGLRLYPPGPLGAPHRAIEDCQVGGYFIPKGTQLLVNVWKLHRDPRVWSEPEKFMPERFLTRQAEVDVFGHHFELLPFGSGRRACPGITFAVQVMHLTVARLLQGFDMTTPSNLPVDMTEGPGVTMPKAHPVEVLMMPRLPSALYEP", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Plant_Cytochrome_P450_Monoox, Cyt_P450_E_grp-I, Cyt_P450_E_grp-I, Cyt_P450_E_grp-I, Cyt_P450_E_grp-I, Cyt_P450_E_grp-I, Cyt_P450_E_grp-I, Cyt_P450_E_grp-I, Cyt_P450, Cyt_P450, Cyt_P450, Cyt_P450, Cyt_P450, Cyt_P450 that shares evolutionary origin and functional similarity; 2. The protein should be classified within Cyt_P450_sf, Cyt_P450_sf, Cyt_P450_sf sharing conserved structural features; 3. The protein should contain Cyt_P450_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MDLLQILLAIAGLLAILLLQKQWRTKTSPGAKAGRKLPPEPAGAWPVIGHLHKLGGPNPIYRNLAEWSDKYGPVMTLKLGMQNAVVVSDREAIKECFTTNDKALADRPPSSIGLHLGFNYAAIGAAPYGPYWRDMRKLVLLEVLSSRRLEMLRNVRISEIGTSIKELYSNIIRSSGGSGPAKVVISHWIEQLTLNYILRTIAGRRFSDDSSKDAQYVKGVINDFMYFAGQFVVSDVIPIPLLRWLDPQGHLKGMKRVAKEVDTMCEAWIQEHVQRRMREKPGPGQEQDFIDVLLNNRDVMRKAQEEIDNHVGKERWVDETDLKHLVYLQAIVKEGLRLYPPGPLGAPHRAIEDCQVGGYFIPKGTQLLVNVWKLHRDPRVWSEPEKFMPERFLTRQAEVDVFGHHFELLPFGSGRRACPGITFAVQVMHLTVARLLQGFDMTTPSNLPVDMTEGPGVTMPKAHPVEVLMMPRLPSALYEP" }, { "InterPro": [ { "InterPro-ID": "IPR000757", "InterPro-Name": "GH16", "InterPro-Type": "DOMAIN", "Beg": 65, "End": 219 }, { "InterPro-ID": "IPR013320", "InterPro-Name": "ConA-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 23, "End": 254 }, { "InterPro-ID": "IPR017168", "InterPro-Name": "Glyco_hydro_16_CRH1_prd", "InterPro-Type": "FAMILY", "Beg": 1, "End": 375 }, { "InterPro-ID": "IPR000757", "InterPro-Name": "GH16", "InterPro-Type": "DOMAIN", "Beg": 29, "End": 246 }, { "InterPro-ID": "IPR050546", "InterPro-Name": "Glycosyl_Hydrlase_16", "InterPro-Type": "FAMILY", "Beg": 2, "End": 254 } ], "response#1": "MRSSTISASAVVLLSGLASAQTFTDCNPTEKTCPSDPAIGGLQVTDFTAGKSSYWEVEDGTTMSYDGTLGAQFVISTATDAPTIKNIGYIMFGRIETWVRASAGTGIVSSFILESDDLDEIDWEWLGANNAEAENNFFGKGNTTTYDRAQYPAVATPIDTFHNYTIDWTAKSTIWYIDGVAVRTLLYDDKQTVGGKNYPQTPMLVKMGSWIGCASKAAETDSATAGTCSWAGGAVDLTQGPFTMYVKNVTIQDYGCATEYTYGDLTGDYTSIKATGGCSADGSAASPSASSSSAASGSSSSTKSSSGSSTLSTVTGTTSAIAVGTATGTATLSAGEKATAAAISGSTTSSSTIAKVTTTSDANSLKKPKHEYGMIDLGVMVLGLGLGYLVM", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more GH16, GH16 that are essential for its biological function; 2. The protein should belong to Glyco_hydro_16_CRH1_prd, Glycosyl_Hydrlase_16 that shares evolutionary origin and functional similarity; 3. The protein should be classified within ConA-like_dom_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MRSSTISASAVVLLSGLASAQTFTDCNPTEKTCPSDPAIGGLQVTDFTAGKSSYWEVEDGTTMSYDGTLGAQFVISTATDAPTIKNIGYIMFGRIETWVRASAGTGIVSSFILESDDLDEIDWEWLGANNAEAENNFFGKGNTTTYDRAQYPAVATPIDTFHNYTIDWTAKSTIWYIDGVAVRTLLYDDKQTVGGKNYPQTPMLVKMGSWIGCASKAAETDSATAGTCSWAGGAVDLTQGPFTMYVKNVTIQDYGCATEYTYGDLTGDYTSIKATGGCSADGSAASPSASSSSAASGSSSSTKSSSGSSTLSTVTGTTSAIAVGTATGTATLSAGEKATAAAISGSTTSSSTIAKVTTTSDANSLKKPKHEYGMIDLGVMVLGLGLGYLVM" }, { "InterPro": [ { "InterPro-ID": "IPR017168", "InterPro-Name": "Glyco_hydro_16_CRH1_prd", "InterPro-Type": "FAMILY", "Beg": 14, "End": 433 }, { "InterPro-ID": "IPR050546", "InterPro-Name": "Glycosyl_Hydrlase_16", "InterPro-Type": "FAMILY", "Beg": 8, "End": 293 }, { "InterPro-ID": "IPR000757", "InterPro-Name": "GH16", "InterPro-Type": "DOMAIN", "Beg": 57, "End": 271 }, { "InterPro-ID": "IPR000757", "InterPro-Name": "GH16", "InterPro-Type": "DOMAIN", "Beg": 91, "End": 264 }, { "InterPro-ID": "IPR013320", "InterPro-Name": "ConA-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 56, "End": 291 } ], "response#1": "MVGKSTLLSVLASASVAFAACSLDSHCPEETPCCSQYGECGTGAYCLGGCDPRMSFSLESCVPEPVCESASYTFTSMDGITSNTKYLGDASKSNWVYSGSPVIYNDNVLLTMSANSVGTVMASSTYMWYGNVKAKFKTSRGQGVITAFILFSDVKDEIDYEFVGSELTTAQSNYYFQGITNYDNELNITLSDTYANYHEYEIDWTPDEITWLVDGQVGRTKKRADTWNATANQWNFPQTPARVQLSLWPGGLASNGAGTIAWAGGEIDWNSEDIQNNGYYYAAFESVDISCYNAKSAPGTNSGKSYYYNSVLGTNNTVIDSKNATILSSLLATGTNMTAGESAAASGSTAASTAATVPGLTGSGGGGVGDNHSDDGSSSSDSSSGSATSSSSGSSSTGSSGFSQGDGSTSTSKSSADSLVANQERVLKGSLFAGIVAVVAMMAL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more GH16, GH16 that are essential for its biological function; 2. The protein should belong to Glyco_hydro_16_CRH1_prd, Glycosyl_Hydrlase_16 that shares evolutionary origin and functional similarity; 3. The protein should be classified within ConA-like_dom_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MVGKSTLLSVLASASVAFAACSLDSHCPEETPCCSQYGECGTGAYCLGGCDPRMSFSLESCVPEPVCESASYTFTSMDGITSNTKYLGDASKSNWVYSGSPVIYNDNVLLTMSANSVGTVMASSTYMWYGNVKAKFKTSRGQGVITAFILFSDVKDEIDYEFVGSELTTAQSNYYFQGITNYDNELNITLSDTYANYHEYEIDWTPDEITWLVDGQVGRTKKRADTWNATANQWNFPQTPARVQLSLWPGGLASNGAGTIAWAGGEIDWNSEDIQNNGYYYAAFESVDISCYNAKSAPGTNSGKSYYYNSVLGTNNTVIDSKNATILSSLLATGTNMTAGESAAASGSTAASTAATVPGLTGSGGGGVGDNHSDDGSSSSDSSSGSATSSSSGSSSTGSSGFSQGDGSTSTSKSSADSLVANQERVLKGSLFAGIVAVVAMMAL" }, { "InterPro": [ { "InterPro-ID": "IPR031521", "InterPro-Name": "DUF4695", "InterPro-Type": "FAMILY", "Beg": 15, "End": 119 }, { "InterPro-ID": "IPR031521", "InterPro-Name": "DUF4695", "InterPro-Type": "FAMILY", "Beg": 1, "End": 123 } ], "response#1": "MAAAKPGELMGICSSYQAVMPHFVCLADEFPQPVRPAKLSKGKGRLRRPRQSRFKTQPVTFDEIQEVEEEGVSPMEEEKAKKSFLQSLECLRRSTQSLSLQREQLSSCKLRNSLDSSDSDSAL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to DUF4695, DUF4695 that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MAAAKPGELMGICSSYQAVMPHFVCLADEFPQPVRPAKLSKGKGRLRRPRQSRFKTQPVTFDEIQEVEEEGVSPMEEEKAKKSFLQSLECLRRSTQSLSLQREQLSSCKLRNSLDSSDSDSAL" }, { "InterPro": [ { "InterPro-ID": "IPR027956", "InterPro-Name": "C1orf127-like", "InterPro-Type": "FAMILY", "Beg": 3, "End": 430 }, { "InterPro-ID": "IPR049521", "InterPro-Name": "DUF4556", "InterPro-Type": "DOMAIN", "Beg": 223, "End": 326 } ], "response#1": "MGSPSSSMTEGDVECFSEYMELWIHRLRIEGLRLWLSGILRIQVGLVSMENLNHQLSSCGFALHRDLDKNYVFRVMYSGCFVQLEHGNYVIVLNLLKRVSRFGGRTQKFMMKCPAVLAPPNREYIQCDSDSIQVTREIPVDNWNNELDWSLALRGSLVVALEDSSLIQINVEMHKPNITVQGRRDTILSPVQVFASEGHFLPLKLVSGNYAYSMEATCPNGNTSSSNETVLHIYKRRMGLTKRGGYQNETLSVSSVMVEQTDTFSWTETTDFVQLIIPTSYIQQNKECLSQTGEKLQQNFYKIDAVLTFKETNHKMHWTMENTSPCSELLKSHSVYDDPQKANFTTHSPTWTAERPEIPADYTTNLTPSVSPSTTSTALQTADPDTGTTSMPTPQLKTTEVFNTSTPLSSQEVFSSTLYSPNHNSTSSSVHQ", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more DUF4556 that are essential for its biological function; 2. The protein should belong to C1orf127-like that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MGSPSSSMTEGDVECFSEYMELWIHRLRIEGLRLWLSGILRIQVGLVSMENLNHQLSSCGFALHRDLDKNYVFRVMYSGCFVQLEHGNYVIVLNLLKRVSRFGGRTQKFMMKCPAVLAPPNREYIQCDSDSIQVTREIPVDNWNNELDWSLALRGSLVVALEDSSLIQINVEMHKPNITVQGRRDTILSPVQVFASEGHFLPLKLVSGNYAYSMEATCPNGNTSSSNETVLHIYKRRMGLTKRGGYQNETLSVSSVMVEQTDTFSWTETTDFVQLIIPTSYIQQNKECLSQTGEKLQQNFYKIDAVLTFKETNHKMHWTMENTSPCSELLKSHSVYDDPQKANFTTHSPTWTAERPEIPADYTTNLTPSVSPSTTSTALQTADPDTGTTSMPTPQLKTTEVFNTSTPLSSQEVFSSTLYSPNHNSTSSSVHQ" }, { "InterPro": [ { "InterPro-ID": "IPR036686", "InterPro-Name": "Hydrophobin_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 21, "End": 88 }, { "InterPro-ID": "IPR010636", "InterPro-Name": "Cerato-ulmin_hydrophobin", "InterPro-Type": "FAMILY", "Beg": 21, "End": 84 }, { "InterPro-ID": "IPR036686", "InterPro-Name": "Hydrophobin_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 16, "End": 88 }, { "InterPro-ID": "IPR010636", "InterPro-Name": "Cerato-ulmin_hydrophobin", "InterPro-Type": "FAMILY", "Beg": 22, "End": 85 } ], "response#1": "MRSFLVIATLAVGAFGQSYDPCPNDLKNHALCCNAGLENLINFDCHTRKFDSLLPPFQATCARTGSYPKCCTIKIISQGLLCEDPAGVENPDTDTFNPEGDNELENLLDDVGNILNEVLNLLN", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Cerato-ulmin_hydrophobin, Cerato-ulmin_hydrophobin that shares evolutionary origin and functional similarity; 2. The protein should be classified within Hydrophobin_sf, Hydrophobin_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MRSFLVIATLAVGAFGQSYDPCPNDLKNHALCCNAGLENLINFDCHTRKFDSLLPPFQATCARTGSYPKCCTIKIISQGLLCEDPAGVENPDTDTFNPEGDNELENLLDDVGNILNEVLNLLN" }, { "InterPro": [ { "InterPro-ID": "IPR002048", "InterPro-Name": "EF_hand_dom", "InterPro-Type": "DOMAIN", "Beg": 44, "End": 107 }, { "InterPro-ID": "IPR011992", "InterPro-Name": "EF-hand-dom_pair", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 5, "End": 107 }, { "InterPro-ID": "IPR002048", "InterPro-Name": "EF_hand_dom", "InterPro-Type": "DOMAIN", "Beg": 39, "End": 74 }, { "InterPro-ID": "IPR008080", "InterPro-Name": "Parvalbumin", "InterPro-Type": "FAMILY", "Beg": 1, "End": 108 }, { "InterPro-ID": "IPR018247", "InterPro-Name": "EF_Hand_1_Ca_BS", "InterPro-Type": "BINDING_SITE", "Beg": 52, "End": 64 }, { "InterPro-ID": "IPR018247", "InterPro-Name": "EF_Hand_1_Ca_BS", "InterPro-Type": "BINDING_SITE", "Beg": 91, "End": 103 }, { "InterPro-ID": "IPR002048", "InterPro-Name": "EF_hand_dom", "InterPro-Type": "DOMAIN", "Beg": 78, "End": 110 }, { "InterPro-ID": "IPR002048", "InterPro-Name": "EF_hand_dom", "InterPro-Type": "DOMAIN", "Beg": 43, "End": 71 }, { "InterPro-ID": "IPR002048", "InterPro-Name": "EF_hand_dom", "InterPro-Type": "DOMAIN", "Beg": 82, "End": 110 } ], "response#1": "MSINKILSAADITKALGEFKGADSFDHKKFFHMIGLKKKNAKDVEAVFYILDKDKSGFIEEDELKSVLKCFAPEGRDLSEKETKDLLTAGDEDGDGKIGVSEFIQLVANS", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more EF_hand_dom, EF_hand_dom, EF_hand_dom, EF_hand_dom, EF_hand_dom that are essential for its biological function; 2. The protein should belong to Parvalbumin that shares evolutionary origin and functional similarity; 3. The protein should be classified within EF-hand-dom_pair sharing conserved structural features; 4. The protein should include a EF_Hand_1_Ca_BS, EF_Hand_1_Ca_BS that enables ligand binding under diverse conditions. The designed protein sequence is ", "reference": "MSINKILSAADITKALGEFKGADSFDHKKFFHMIGLKKKNAKDVEAVFYILDKDKSGFIEEDELKSVLKCFAPEGRDLSEKETKDLLTAGDEDGDGKIGVSEFIQLVANS" }, { "InterPro": [ { "InterPro-ID": "IPR008271", "InterPro-Name": "Ser/Thr_kinase_AS", "InterPro-Type": "ACTIVE_SITE", "Beg": 211, "End": 223 }, { "InterPro-ID": "IPR050823", "InterPro-Name": "Plant_Ser_Thr_Prot_Kinase", "InterPro-Type": "FAMILY", "Beg": 39, "End": 365 }, { "InterPro-ID": "IPR011009", "InterPro-Name": "Kinase-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 54, "End": 362 }, { "InterPro-ID": "IPR001245", "InterPro-Name": "Ser-Thr/Tyr_kinase_cat_dom", "InterPro-Type": "DOMAIN", "Beg": 89, "End": 361 }, { "InterPro-ID": "IPR000719", "InterPro-Name": "Prot_kinase_dom", "InterPro-Type": "DOMAIN", "Beg": 85, "End": 366 } ], "response#1": "MAVMKFTWRSIIPRCSKGIEEPEAEAEAEPETKKQDSKQGSFSRLAMIDLSYPSSRFTEDLSTSLAGSNLYVFTLEELKVITQCFSSANFLGEGGFGPVHKGFIDDNLRPGLEAQPVAVKLLDLEGLQGHREWLTEVVFLAQLSHPHLVKLIGYCCEDEHRLLVYEYMPRGSLENQLFAKYSVPLPWSTRMKIALGAAKGLAYLHEAEKPVIYRDFKASNILLDSDYSAKLSDFGLAKDGPEGDKTHVSTRVMGTRGYAAPEYIMTGHLTAMSDVYSFGVVLLELLTGRRSLDKSRSPREQNLAEWARPMLNESRRLARIMDPKLEGQYSETGARKAAALAYQCLSHRAKQRPKMSDVVNILEPLLDYEETSVGTFVYTVPTHQNGGSPPKDDTDTKECEAKTELKKENGDHHNRHHHRRSHKSRDGHRHRNKSSSQSSVHSENYTSKQTLENGSNEECNID", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Ser-Thr/Tyr_kinase_cat_dom, Prot_kinase_dom that are essential for its biological function; 2. The protein should belong to Plant_Ser_Thr_Prot_Kinase that shares evolutionary origin and functional similarity; 3. The protein should be classified within Kinase-like_dom_sf sharing conserved structural features; 4. The protein must have Ser/Thr_kinase_AS that is conserved among related catalytic enzymes. The designed protein sequence is ", "reference": "MAVMKFTWRSIIPRCSKGIEEPEAEAEAEPETKKQDSKQGSFSRLAMIDLSYPSSRFTEDLSTSLAGSNLYVFTLEELKVITQCFSSANFLGEGGFGPVHKGFIDDNLRPGLEAQPVAVKLLDLEGLQGHREWLTEVVFLAQLSHPHLVKLIGYCCEDEHRLLVYEYMPRGSLENQLFAKYSVPLPWSTRMKIALGAAKGLAYLHEAEKPVIYRDFKASNILLDSDYSAKLSDFGLAKDGPEGDKTHVSTRVMGTRGYAAPEYIMTGHLTAMSDVYSFGVVLLELLTGRRSLDKSRSPREQNLAEWARPMLNESRRLARIMDPKLEGQYSETGARKAAALAYQCLSHRAKQRPKMSDVVNILEPLLDYEETSVGTFVYTVPTHQNGGSPPKDDTDTKECEAKTELKKENGDHHNRHHHRRSHKSRDGHRHRNKSSSQSSVHSENYTSKQTLENGSNEECNID" }, { "InterPro": [ { "InterPro-ID": "IPR000276", "InterPro-Name": "GPCR_Rhodpsn", "InterPro-Type": "FAMILY", "Beg": 103, "End": 119 }, { "InterPro-ID": "IPR000276", "InterPro-Name": "GPCR_Rhodpsn", "InterPro-Type": "FAMILY", "Beg": 35, "End": 293 }, { "InterPro-ID": "IPR000276", "InterPro-Name": "GPCR_Rhodpsn", "InterPro-Type": "FAMILY", "Beg": 275, "End": 301 }, { "InterPro-ID": "IPR000276", "InterPro-Name": "GPCR_Rhodpsn", "InterPro-Type": "FAMILY", "Beg": 19, "End": 43 }, { "InterPro-ID": "IPR000276", "InterPro-Name": "GPCR_Rhodpsn", "InterPro-Type": "FAMILY", "Beg": 133, "End": 154 }, { "InterPro-ID": "IPR000276", "InterPro-Name": "GPCR_Rhodpsn", "InterPro-Type": "FAMILY", "Beg": 52, "End": 73 }, { "InterPro-ID": "IPR000276", "InterPro-Name": "GPCR_Rhodpsn", "InterPro-Type": "FAMILY", "Beg": 223, "End": 247 }, { "InterPro-ID": "IPR000276", "InterPro-Name": "GPCR_Rhodpsn", "InterPro-Type": "FAMILY", "Beg": 97, "End": 119 }, { "InterPro-ID": "IPR000276", "InterPro-Name": "GPCR_Rhodpsn", "InterPro-Type": "FAMILY", "Beg": 183, "End": 206 }, { "InterPro-ID": "IPR017452", "InterPro-Name": "GPCR_Rhodpsn_7TM", "InterPro-Type": "DOMAIN", "Beg": 34, "End": 293 }, { "InterPro-ID": "IPR002276", "InterPro-Name": "GPR4_orph", "InterPro-Type": "FAMILY", "Beg": 209, "End": 221 }, { "InterPro-ID": "IPR002276", "InterPro-Name": "GPR4_orph", "InterPro-Type": "FAMILY", "Beg": 148, "End": 166 }, { "InterPro-ID": "IPR002276", "InterPro-Name": "GPR4_orph", "InterPro-Type": "FAMILY", "Beg": 124, "End": 136 }, { "InterPro-ID": "IPR002276", "InterPro-Name": "GPR4_orph", "InterPro-Type": "FAMILY", "Beg": 1, "End": 22 } ], "response#1": "MSNFTPDACNVDSGLDSVLPPSLYALVFTLGLPANLLALWAAWLQVRKGRELGVYLLNLSLSDLLLICALPPWTDYYLRRDVWGYGPGACRLFGFVFYTNLYVGAAFLSCVSADRYLAVAHPLRFPGARPIRSAAAVSALIWMLELAANAPPLLGEAIHRDRYNHTFCYESYPLSGRGAALANVGRVLAGFLLPWGVMMLCYAGLLRALRGSASCEQRERRRVRRLALGLPCVALLCYGPYHALLLLRSLVFLVGGGSVDAGGGCALEERLFPAYHASLALATLNCLADPALYCLACPGARGEVAKVVGGVVAWAMGKERRAWGERGGNGRGCGEGEEVGMVELRGNGREFVV", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more GPCR_Rhodpsn_7TM that are essential for its biological function; 2. The protein should belong to GPCR_Rhodpsn, GPCR_Rhodpsn, GPCR_Rhodpsn, GPCR_Rhodpsn, GPCR_Rhodpsn, GPCR_Rhodpsn, GPCR_Rhodpsn, GPCR_Rhodpsn, GPCR_Rhodpsn, GPR4_orph, GPR4_orph, GPR4_orph, GPR4_orph that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MSNFTPDACNVDSGLDSVLPPSLYALVFTLGLPANLLALWAAWLQVRKGRELGVYLLNLSLSDLLLICALPPWTDYYLRRDVWGYGPGACRLFGFVFYTNLYVGAAFLSCVSADRYLAVAHPLRFPGARPIRSAAAVSALIWMLELAANAPPLLGEAIHRDRYNHTFCYESYPLSGRGAALANVGRVLAGFLLPWGVMMLCYAGLLRALRGSASCEQRERRRVRRLALGLPCVALLCYGPYHALLLLRSLVFLVGGGSVDAGGGCALEERLFPAYHASLALATLNCLADPALYCLACPGARGEVAKVVGGVVAWAMGKERRAWGERGGNGRGCGEGEEVGMVELRGNGREFVV" }, { "InterPro": [ { "InterPro-ID": "IPR000742", "InterPro-Name": "EGF-like_dom", "InterPro-Type": "DOMAIN", "Beg": 186, "End": 227 }, { "InterPro-ID": "IPR024731", "InterPro-Name": "EGF_dom", "InterPro-Type": "DOMAIN", "Beg": 147, "End": 185 }, { "InterPro-ID": "IPR000742", "InterPro-Name": "EGF-like_dom", "InterPro-Type": "DOMAIN", "Beg": 146, "End": 186 }, { "InterPro-ID": "IPR000742", "InterPro-Name": "EGF-like_dom", "InterPro-Type": "DOMAIN", "Beg": 236, "End": 280 }, { "InterPro-ID": "IPR000742", "InterPro-Name": "EGF-like_dom", "InterPro-Type": "DOMAIN", "Beg": 189, "End": 233 } ], "response#1": "MRGGTSALLHALTFSGAVWMCTPAEALPIQKSVQLGSFDKVVPSREVVSESLAPSFAVTETHSSVQSPSKQETQLCAISSEGKPCRNRQLHTDNGYFIGASCPKSACCSKTMCGPGGCGEFCSSNWIFCSSSLIYHPDKSYGGDCSCEKQGHRCDKNAECVENLDAGGGVHCKCKDGFVGTGLTCSEDPCSKRGNAKCGPNGTCIVVDSVSYTCTCGDGETLVNLPEGGQGCKRTGCHAFRENCSPGRCIDDASHENGYTCECPTGYSREVTSKAEESCVEGVEVTLAEKCEKEFGISASSCKCDNGYSGSASATSHHGKGESGSEGSLSEKMNIVFKCPSGYHPRYHAHTVTCEKIKHFALDGAGNHDTTTYVARRRYPASL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more EGF-like_dom, EGF_dom, EGF-like_dom, EGF-like_dom, EGF-like_dom that are essential for its biological function. The designed protein sequence is ", "reference": "MRGGTSALLHALTFSGAVWMCTPAEALPIQKSVQLGSFDKVVPSREVVSESLAPSFAVTETHSSVQSPSKQETQLCAISSEGKPCRNRQLHTDNGYFIGASCPKSACCSKTMCGPGGCGEFCSSNWIFCSSSLIYHPDKSYGGDCSCEKQGHRCDKNAECVENLDAGGGVHCKCKDGFVGTGLTCSEDPCSKRGNAKCGPNGTCIVVDSVSYTCTCGDGETLVNLPEGGQGCKRTGCHAFRENCSPGRCIDDASHENGYTCECPTGYSREVTSKAEESCVEGVEVTLAEKCEKEFGISASSCKCDNGYSGSASATSHHGKGESGSEGSLSEKMNIVFKCPSGYHPRYHAHTVTCEKIKHFALDGAGNHDTTTYVARRRYPASL" }, { "InterPro": [ { "InterPro-ID": "IPR045122", "InterPro-Name": "Csc1-like", "InterPro-Type": "FAMILY", "Beg": 45, "End": 779 }, { "InterPro-ID": "IPR027815", "InterPro-Name": "CSC1/OSCA1-like_cyt", "InterPro-Type": "DOMAIN", "Beg": 233, "End": 415 }, { "InterPro-ID": "IPR003864", "InterPro-Name": "CSC1/OSCA1-like_7TM", "InterPro-Type": "DOMAIN", "Beg": 426, "End": 698 }, { "InterPro-ID": "IPR032880", "InterPro-Name": "Csc1/OSCA1-like_N", "InterPro-Type": "DOMAIN", "Beg": 112, "End": 217 } ], "response#1": "MLPYVIATLGSAGSTCKASTCSNSTKDYCYSARIRSTVLQGLPFGGVPTVLALDFMCFLALLFVFSILRKVAWDYGRLALVTDADSIASALHSDNHDRYERLTSVSSSVDFDQRDNGFCSWLTAIFRIKDDEIRDKCGGDAVHYLSFQRHIIGLLVAVGVLSVGIVLPVNFSGDLLENNAYSFGRTTIANLNSGNNLLWLHTSFAFLYLLLTVYSMRRHTSKMRYKEDDLVKRTLFINGISKYAEPEKIKKHFEEAYANCTVLEARPCYDVARLMFLDAERRKAERGRIYFTNLQSKENTPSMINPKPCGHLCCCVIRGCEEVEAIEYYTKLEEKLKDDYKREKEKVNEKPLGMAFVTFHNETITAIILKDFNACKCQGCACRGEPRASSCSESLHVSNWTVSYAPDPQNIYWEHLSIRGFIWWIRCLVINVVLFILLFFLTTPAIIITTMDKFNVTKPVEYLNNPIITQFFPTLLLWCFSALLPTIVYYSAFFEAHWTRSGENRTTMHKCYTFLIFMVLLLPSLGLSSLDVFFRWLFDKKFLAEAAVRFECVFLPDNGAFFVNYVIASAFIGNAMDLLRIPGLLMYMIRLCLARSAAERRNVKRHQAYEFQFGAAYAWMMCVFTVVMTYSITCPIIVPFGLMYMLLKHLVDRYNLYYAYLPAKLDKKIHSGAVNQVVAAPILCLFWLLFFSTMRTGFLAPTSMFTFVVLVITIVICLCHVCFGHFKYLSAHNYKIEHTEVDTTESRQNGRPATNLPAPKSAKYIAQVLQDSSPEGEATESEEQGSQDEELITTDGMNDTDFQSCEDSLIENEIRQ", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more CSC1/OSCA1-like_cyt, CSC1/OSCA1-like_7TM, Csc1/OSCA1-like_N that are essential for its biological function; 2. The protein should belong to Csc1-like that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MLPYVIATLGSAGSTCKASTCSNSTKDYCYSARIRSTVLQGLPFGGVPTVLALDFMCFLALLFVFSILRKVAWDYGRLALVTDADSIASALHSDNHDRYERLTSVSSSVDFDQRDNGFCSWLTAIFRIKDDEIRDKCGGDAVHYLSFQRHIIGLLVAVGVLSVGIVLPVNFSGDLLENNAYSFGRTTIANLNSGNNLLWLHTSFAFLYLLLTVYSMRRHTSKMRYKEDDLVKRTLFINGISKYAEPEKIKKHFEEAYANCTVLEARPCYDVARLMFLDAERRKAERGRIYFTNLQSKENTPSMINPKPCGHLCCCVIRGCEEVEAIEYYTKLEEKLKDDYKREKEKVNEKPLGMAFVTFHNETITAIILKDFNACKCQGCACRGEPRASSCSESLHVSNWTVSYAPDPQNIYWEHLSIRGFIWWIRCLVINVVLFILLFFLTTPAIIITTMDKFNVTKPVEYLNNPIITQFFPTLLLWCFSALLPTIVYYSAFFEAHWTRSGENRTTMHKCYTFLIFMVLLLPSLGLSSLDVFFRWLFDKKFLAEAAVRFECVFLPDNGAFFVNYVIASAFIGNAMDLLRIPGLLMYMIRLCLARSAAERRNVKRHQAYEFQFGAAYAWMMCVFTVVMTYSITCPIIVPFGLMYMLLKHLVDRYNLYYAYLPAKLDKKIHSGAVNQVVAAPILCLFWLLFFSTMRTGFLAPTSMFTFVVLVITIVICLCHVCFGHFKYLSAHNYKIEHTEVDTTESRQNGRPATNLPAPKSAKYIAQVLQDSSPEGEATESEEQGSQDEELITTDGMNDTDFQSCEDSLIENEIRQ" }, { "InterPro": [ { "InterPro-ID": "IPR017972", "InterPro-Name": "Cyt_P450_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 435, "End": 444 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 312, "End": 338 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 432, "End": 442 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 396, "End": 420 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 355, "End": 373 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 442, "End": 465 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 65, "End": 84 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 292, "End": 309 }, { "InterPro-ID": "IPR036396", "InterPro-Name": "Cyt_P450_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 34, "End": 496 }, { "InterPro-ID": "IPR036396", "InterPro-Name": "Cyt_P450_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 29, "End": 497 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 37, "End": 480 } ], "response#1": "MEMMQLSFASAVVYSLIFFVFLLVKQLLKPKSHKKLPPGPWTLPIIGNLHQILGALPHRIFKDLSDKYGPLMRIMMGERTTIIVSSATMAKVVLHTHGLAVANRPINSVAKVICYNNLGVTFAEYGEYLKQLRQLYMLELLSPKRVQSFSAVFEDELQTFVKSIKSEVGQPMIIYEKSVTYLYSTICRVMLGNVCNEREKLIKICKKVSFYSAAPIRIEDLFPSMKFIISRIFSTNSILKDLLKDLDDVLDIVIAERENSQYAQEEEDMLGILLKHKRSDGNNSKLKITNKDIKAIIFELLLAATLSVADVVEWAMVEILRHPKVLKQVHDEVRQAFKGQKTITGSDLGKLEYLHMCFKESTRLHPAAPLLFPREAREEFEIDGYTIPKGSWVLTNYWAVGRDPRIWPKPDEFDPERFRNSDIEFYGNHFELIPFGTGRRGCPGILFGITEALYLLAALFYHFDWKLAGGITPEEIDMTEVFGAGCILKNPLNLIPRLAEN", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Cyt_P450_E_grp-I, Cyt_P450_E_grp-I, Cyt_P450_E_grp-I, Cyt_P450_E_grp-I, Cyt_P450_E_grp-I, Cyt_P450_E_grp-I, Cyt_P450_E_grp-I, Cyt_P450 that shares evolutionary origin and functional similarity; 2. The protein should be classified within Cyt_P450_sf, Cyt_P450_sf sharing conserved structural features; 3. The protein should contain Cyt_P450_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MEMMQLSFASAVVYSLIFFVFLLVKQLLKPKSHKKLPPGPWTLPIIGNLHQILGALPHRIFKDLSDKYGPLMRIMMGERTTIIVSSATMAKVVLHTHGLAVANRPINSVAKVICYNNLGVTFAEYGEYLKQLRQLYMLELLSPKRVQSFSAVFEDELQTFVKSIKSEVGQPMIIYEKSVTYLYSTICRVMLGNVCNEREKLIKICKKVSFYSAAPIRIEDLFPSMKFIISRIFSTNSILKDLLKDLDDVLDIVIAERENSQYAQEEEDMLGILLKHKRSDGNNSKLKITNKDIKAIIFELLLAATLSVADVVEWAMVEILRHPKVLKQVHDEVRQAFKGQKTITGSDLGKLEYLHMCFKESTRLHPAAPLLFPREAREEFEIDGYTIPKGSWVLTNYWAVGRDPRIWPKPDEFDPERFRNSDIEFYGNHFELIPFGTGRRGCPGILFGITEALYLLAALFYHFDWKLAGGITPEEIDMTEVFGAGCILKNPLNLIPRLAEN" }, { "InterPro": [ { "InterPro-ID": "IPR017972", "InterPro-Name": "Cyt_P450_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 435, "End": 444 }, { "InterPro-ID": "IPR036396", "InterPro-Name": "Cyt_P450_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 26, "End": 495 }, { "InterPro-ID": "IPR036396", "InterPro-Name": "Cyt_P450_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 31, "End": 495 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 396, "End": 420 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 432, "End": 442 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 312, "End": 338 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 355, "End": 373 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 62, "End": 81 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 442, "End": 465 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 292, "End": 309 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 34, "End": 480 } ], "response#1": "MEFSFSSPLLYILYFLLFFIVRQLLKPKSNRKLPPGPRTLPIIGNLHQLRGSLPHRTLKKLSDKHGPLMHLKMGERSAIIVSDARMAKIVLHNHGLAVADRSVNTVASIMTYNSLGVTFAQYGDYLTKLRQIYTLELLSPKKVRSFYNCFEDELDVFVKSIRSQVGQPMVLYEKVSTYLYATICRTIFGSVCKEREKMIKIVKRTSLLSGTPLRMEDLFPSMRVFCRFSKTLNQLRGLLQEMDGILEDIIVEREKTTEILKEAKDDEDMLSVLLRHKWYNPSGARFRITNADIKAIIFELILAATLSVADVVEWAMVEILRHPAILKKVYDEGRGICKEKKRVTGYDVEKMEYMRLCVKESTRVHPAAPLLVPRECREDFEVDGYTVPKGAWVLTNCWAIQMDPEIWPEPEKFDPERYIRNPMDFYGSNFELIPFGTGRRGCPGILYGVTNAELLLAAMFYHFDWEIADGKKPEDIDLTENFGAGCIMKYPLTLVPHLANE", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Cyt_P450_E_grp-I, Cyt_P450_E_grp-I, Cyt_P450_E_grp-I, Cyt_P450_E_grp-I, Cyt_P450_E_grp-I, Cyt_P450_E_grp-I, Cyt_P450_E_grp-I, Cyt_P450 that shares evolutionary origin and functional similarity; 2. The protein should be classified within Cyt_P450_sf, Cyt_P450_sf sharing conserved structural features; 3. The protein should contain Cyt_P450_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MEFSFSSPLLYILYFLLFFIVRQLLKPKSNRKLPPGPRTLPIIGNLHQLRGSLPHRTLKKLSDKHGPLMHLKMGERSAIIVSDARMAKIVLHNHGLAVADRSVNTVASIMTYNSLGVTFAQYGDYLTKLRQIYTLELLSPKKVRSFYNCFEDELDVFVKSIRSQVGQPMVLYEKVSTYLYATICRTIFGSVCKEREKMIKIVKRTSLLSGTPLRMEDLFPSMRVFCRFSKTLNQLRGLLQEMDGILEDIIVEREKTTEILKEAKDDEDMLSVLLRHKWYNPSGARFRITNADIKAIIFELILAATLSVADVVEWAMVEILRHPAILKKVYDEGRGICKEKKRVTGYDVEKMEYMRLCVKESTRVHPAAPLLVPRECREDFEVDGYTVPKGAWVLTNCWAIQMDPEIWPEPEKFDPERYIRNPMDFYGSNFELIPFGTGRRGCPGILYGVTNAELLLAAMFYHFDWEIADGKKPEDIDLTENFGAGCIMKYPLTLVPHLANE" }, { "InterPro": [ { "InterPro-ID": "IPR036388", "InterPro-Name": "WH-like_DNA-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 3, "End": 115 }, { "InterPro-ID": "IPR016461", "InterPro-Name": "COMT-like", "InterPro-Type": "FAMILY", "Beg": 24, "End": 363 }, { "InterPro-ID": "IPR001077", "InterPro-Name": "O_MeTrfase_dom", "InterPro-Type": "DOMAIN", "Beg": 140, "End": 345 }, { "InterPro-ID": "IPR016461", "InterPro-Name": "COMT-like", "InterPro-Type": "FAMILY", "Beg": 23, "End": 345 }, { "InterPro-ID": "IPR029063", "InterPro-Name": "SAM-dependent_MTases_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 116, "End": 363 }, { "InterPro-ID": "IPR012967", "InterPro-Name": "Plant_O-MeTrfase_dimerisation", "InterPro-Type": "DOMAIN", "Beg": 18, "End": 117 }, { "InterPro-ID": "IPR016461", "InterPro-Name": "COMT-like", "InterPro-Type": "FAMILY", "Beg": 3, "End": 364 }, { "InterPro-ID": "IPR036390", "InterPro-Name": "WH_DNA-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 18, "End": 119 }, { "InterPro-ID": "IPR029063", "InterPro-Name": "SAM-dependent_MTases_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 126, "End": 360 } ], "response#1": "MGSYHDEKNVMGGSDQGELCSLAMTIASGSVPAMVLKALIELDVLELIKRAGPGAQLSPAQIVAQLPTKNPDAGTMLDRMLRLLASYEILSCSTQTLPDGRVERLYGLAPVCQFFTNNEDGATLGAIVQLSQEKLVVESWYHLKDAVLDGGIPFKKAQGMTIYEYPKTDPRFNQVFNSGMSNYSTIIMRDLLERYKGFEGISTLVDIAGGTGASINMVVSKYPTIKGINFDLPHVIKDAPSYDGVEHVGGDMFESVTKADAMLIKWTLCDWSDEHCLKLLKNCYNALPDNGKVIVCDYVLPMAPETSNAAKTVFLLDAIMLANFVGGKGRTKQEFEALARKVGFEGFEVPCSSYDFSVMELFKKKNN", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more O_MeTrfase_dom, Plant_O-MeTrfase_dimerisation that are essential for its biological function; 2. The protein should belong to COMT-like, COMT-like, COMT-like that shares evolutionary origin and functional similarity; 3. The protein should be classified within WH-like_DNA-bd_sf, SAM-dependent_MTases_sf, WH_DNA-bd_sf, SAM-dependent_MTases_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MGSYHDEKNVMGGSDQGELCSLAMTIASGSVPAMVLKALIELDVLELIKRAGPGAQLSPAQIVAQLPTKNPDAGTMLDRMLRLLASYEILSCSTQTLPDGRVERLYGLAPVCQFFTNNEDGATLGAIVQLSQEKLVVESWYHLKDAVLDGGIPFKKAQGMTIYEYPKTDPRFNQVFNSGMSNYSTIIMRDLLERYKGFEGISTLVDIAGGTGASINMVVSKYPTIKGINFDLPHVIKDAPSYDGVEHVGGDMFESVTKADAMLIKWTLCDWSDEHCLKLLKNCYNALPDNGKVIVCDYVLPMAPETSNAAKTVFLLDAIMLANFVGGKGRTKQEFEALARKVGFEGFEVPCSSYDFSVMELFKKKNN" }, { "InterPro": [ { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 31, "End": 116 }, { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 31, "End": 119 } ], "response#1": "MVAIKSLAILALPVMAMASPLVPRTDSPSQCNNGSLQCCNSSMTQDRGNLQIAQGVLGGLLGGLLGLGGLLDLVDLNALIGVQCSPISIVGNANTCTQQTVCCSNNNFNGLIALGCTPININL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Hydrophobin, Hydrophobin that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MVAIKSLAILALPVMAMASPLVPRTDSPSQCNNGSLQCCNSSMTQDRGNLQIAQGVLGGLLGGLLGLGGLLDLVDLNALIGVQCSPISIVGNANTCTQQTVCCSNNNFNGLIALGCTPININL" }, { "InterPro": [ { "InterPro-ID": "IPR010489", "InterPro-Name": "Effector_NleG", "InterPro-Type": "FAMILY", "Beg": 95, "End": 205 }, { "InterPro-ID": "IPR038436", "InterPro-Name": "Effector_NleG_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 107, "End": 207 } ], "response#1": "MPIMLNFSNGRILPESEVEALRNVARSNQSDVLLVGSRSLRLHHISFMDGFSVEPIPGSFLDRIGERRHRRLAESLERQLNGGSSFLQAFSQYIEQTSSAPPLQESVRNEVQSRVNSYAFSVNPGDFPCSVLHLSCPITLCVPETGVFVKNARCSKVCSLYDISALTEMLRRNASHPLSREAFTPGMIVHKEECNFNTTEQHFCILPRSDTRL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Effector_NleG that shares evolutionary origin and functional similarity; 2. The protein should be classified within Effector_NleG_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MPIMLNFSNGRILPESEVEALRNVARSNQSDVLLVGSRSLRLHHISFMDGFSVEPIPGSFLDRIGERRHRRLAESLERQLNGGSSFLQAFSQYIEQTSSAPPLQESVRNEVQSRVNSYAFSVNPGDFPCSVLHLSCPITLCVPETGVFVKNARCSKVCSLYDISALTEMLRRNASHPLSREAFTPGMIVHKEECNFNTTEQHFCILPRSDTRL" }, { "InterPro": [ { "InterPro-ID": "IPR006343", "InterPro-Name": "DnaD_dom", "InterPro-Type": "DOMAIN", "Beg": 326, "End": 386 } ], "response#1": "MGRQAFEFGLRPKDQFKVMQHFDLNTNHLEVLNRLYTPLIGTQAVGLYHFMTQFVKESHNETLILSHYIFMNELKINLLEFRQQMDLLEAIGLLKAFVKHDEQETQFVYQLIQPPSAHLFFNDPMLSIFLYSEVEHRRFHELKKYFEYQQIDLSEFKQVTRQFTDVFKVPSTKIDIDTSDIPINEPYQGIDLSNESFDFEMLRQMLGKHFISQDIVTKDAKRLITQLATLYGLTADGMKHVILNSITSGQQLSFEEMRKQARSYYLMEHENQMPKLQVKSPATSSSAGKSSEVNPKPQSDEWFELLEQTSPIDMLASWSESEPTISQKTMVEELIEREKMSFGVINILLQFVMLKEDMKLPKAYILEIASNWKKKGIKTAKEAYNYAKKVNQPKNEGSSGNYQKRGSYYGQRNRISKEKTPKWLENRDKPSEEDSAKDNSVDDQQLEQDRQAFLDKLSKKWEEDSQ", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more DnaD_dom that are essential for its biological function. The designed protein sequence is ", "reference": "MGRQAFEFGLRPKDQFKVMQHFDLNTNHLEVLNRLYTPLIGTQAVGLYHFMTQFVKESHNETLILSHYIFMNELKINLLEFRQQMDLLEAIGLLKAFVKHDEQETQFVYQLIQPPSAHLFFNDPMLSIFLYSEVEHRRFHELKKYFEYQQIDLSEFKQVTRQFTDVFKVPSTKIDIDTSDIPINEPYQGIDLSNESFDFEMLRQMLGKHFISQDIVTKDAKRLITQLATLYGLTADGMKHVILNSITSGQQLSFEEMRKQARSYYLMEHENQMPKLQVKSPATSSSAGKSSEVNPKPQSDEWFELLEQTSPIDMLASWSESEPTISQKTMVEELIEREKMSFGVINILLQFVMLKEDMKLPKAYILEIASNWKKKGIKTAKEAYNYAKKVNQPKNEGSSGNYQKRGSYYGQRNRISKEKTPKWLENRDKPSEEDSAKDNSVDDQQLEQDRQAFLDKLSKKWEEDSQ" }, { "InterPro": [ { "InterPro-ID": "IPR001009", "InterPro-Name": "PA/PA-X", "InterPro-Type": "FAMILY", "Beg": 21, "End": 201 }, { "InterPro-ID": "IPR038372", "InterPro-Name": "PA/PA-X_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1, "End": 197 } ], "response#1": "MEDFVRQCFNPMIVELAEKAMKEYGEDLKIETNKFAAICTHLEVCFMYSDFHFINEQGESIVVELDDPNALLKHRFEIIEGRDRTMAWTVVNSICNTTGAEKPKFLPDLYDYKENRFIEIGVTRREVHIYYLEKANKIKSENTHIHIFSFTGEEMATKADYTLDEESRARIKTRLFTIRQEMANRGLWDSFVSPKEAKKQLKKNLKSQELCVGLPTKVSHRTSPALRILEPMWMDSNRTAALRASFLKCPKK", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to PA/PA-X that shares evolutionary origin and functional similarity; 2. The protein should be classified within PA/PA-X_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MEDFVRQCFNPMIVELAEKAMKEYGEDLKIETNKFAAICTHLEVCFMYSDFHFINEQGESIVVELDDPNALLKHRFEIIEGRDRTMAWTVVNSICNTTGAEKPKFLPDLYDYKENRFIEIGVTRREVHIYYLEKANKIKSENTHIHIFSFTGEEMATKADYTLDEESRARIKTRLFTIRQEMANRGLWDSFVSPKEAKKQLKKNLKSQELCVGLPTKVSHRTSPALRILEPMWMDSNRTAALRASFLKCPKK" }, { "InterPro": [ { "InterPro-ID": "IPR001009", "InterPro-Name": "PA/PA-X", "InterPro-Type": "FAMILY", "Beg": 21, "End": 195 }, { "InterPro-ID": "IPR038372", "InterPro-Name": "PA/PA-X_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1, "End": 197 } ], "response#1": "MEDFVRQCFNPMIVELAEKAMKEYGEDPKIETNKFAAICTHLEVCFMYSDFHFIDERSESIIVESGDPNALLKHRFEIIEGRDRTMAWTVVNSICNTTGVEKPKFLPDLYDYKENRFIEIGVTRREVHTYYLEKANKIKSEETHIHIFSFTGEEMATKADYTLDEESRARIKTRLFTIRQEMASRGLWDSFVNPREAKRQLKKNLKSLEPCADLQTKVSHRTSPALKTLEPMWMDSNRTAALRASFLKCQKK", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to PA/PA-X that shares evolutionary origin and functional similarity; 2. The protein should be classified within PA/PA-X_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MEDFVRQCFNPMIVELAEKAMKEYGEDPKIETNKFAAICTHLEVCFMYSDFHFIDERSESIIVESGDPNALLKHRFEIIEGRDRTMAWTVVNSICNTTGVEKPKFLPDLYDYKENRFIEIGVTRREVHTYYLEKANKIKSEETHIHIFSFTGEEMATKADYTLDEESRARIKTRLFTIRQEMASRGLWDSFVNPREAKRQLKKNLKSLEPCADLQTKVSHRTSPALKTLEPMWMDSNRTAALRASFLKCQKK" }, { "InterPro": [ { "InterPro-ID": "IPR015424", "InterPro-Name": "PyrdxlP-dep_Trfase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 175, "End": 539 }, { "InterPro-ID": "IPR000277", "InterPro-Name": "Cys/Met-Metab_PyrdxlP-dep_enz", "InterPro-Type": "FAMILY", "Beg": 155, "End": 537 }, { "InterPro-ID": "IPR054542", "InterPro-Name": "Cys_met_metab_PP", "InterPro-Type": "CONSERVED_SITE", "Beg": 348, "End": 362 }, { "InterPro-ID": "IPR015421", "InterPro-Name": "PyrdxlP-dep_Trfase_major", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 144, "End": 402 }, { "InterPro-ID": "IPR015422", "InterPro-Name": "PyrdxlP-dep_Trfase_small", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 406, "End": 537 }, { "InterPro-ID": "IPR000277", "InterPro-Name": "Cys/Met-Metab_PyrdxlP-dep_enz", "InterPro-Type": "FAMILY", "Beg": 170, "End": 538 }, { "InterPro-ID": "IPR044639", "InterPro-Name": "CGS1/2", "InterPro-Type": "FAMILY", "Beg": 50, "End": 540 } ], "response#1": "MAVSSCARAFPSFECRSDAEFSGGIPRHDIPNSGKASILSHGSSVHGLSSLIYRFPPNFVRQLSIKARRNCSNIGVAQVVAASWSNNNSSPDFTPVAKAVDAAAAAAAAIAPVDTTVVNEDVALVENETCNDQNVQFDSLPSMKYASFLNSDGSVAIHAGERLGRGIVTDAITTPVVNTSAYFFNKTSELIDFKEKRRASFEYGRYGNPTTVVLEEKISALEGAESTLLMASGMCASTVMLLALVPAGGHIVTTTDCYRKTRIFIETILPKMGITATVIDPADVGALELALNQKKVNLFFTESPTNPFLRCVDIELVSKLCHEKGALVCIDGTFATPLNQKALALGADLVLHSATKFLGGHNDVLAGCISGPLKLVSEIRNLHHILGGALNPNAAYLIIRGMKTLHLRVQQQNSTALRMAEILEAHPKVRHVYYPGLQSHPEHHIAKKQMTGFGGVVSFEVDGDLLTTAKFVDALKIPYIAPSFGGCESIVDQPAIMSYWDLSQSDRAKYGIMDNLVRFSFGVEDFDDLKADILQALDSI", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Cys/Met-Metab_PyrdxlP-dep_enz, Cys/Met-Metab_PyrdxlP-dep_enz, CGS1/2 that shares evolutionary origin and functional similarity; 2. The protein should be classified within PyrdxlP-dep_Trfase, PyrdxlP-dep_Trfase_major, PyrdxlP-dep_Trfase_small sharing conserved structural features; 3. The protein should contain Cys_met_metab_PP that is preserved across related proteins. The designed protein sequence is ", "reference": "MAVSSCARAFPSFECRSDAEFSGGIPRHDIPNSGKASILSHGSSVHGLSSLIYRFPPNFVRQLSIKARRNCSNIGVAQVVAASWSNNNSSPDFTPVAKAVDAAAAAAAAIAPVDTTVVNEDVALVENETCNDQNVQFDSLPSMKYASFLNSDGSVAIHAGERLGRGIVTDAITTPVVNTSAYFFNKTSELIDFKEKRRASFEYGRYGNPTTVVLEEKISALEGAESTLLMASGMCASTVMLLALVPAGGHIVTTTDCYRKTRIFIETILPKMGITATVIDPADVGALELALNQKKVNLFFTESPTNPFLRCVDIELVSKLCHEKGALVCIDGTFATPLNQKALALGADLVLHSATKFLGGHNDVLAGCISGPLKLVSEIRNLHHILGGALNPNAAYLIIRGMKTLHLRVQQQNSTALRMAEILEAHPKVRHVYYPGLQSHPEHHIAKKQMTGFGGVVSFEVDGDLLTTAKFVDALKIPYIAPSFGGCESIVDQPAIMSYWDLSQSDRAKYGIMDNLVRFSFGVEDFDDLKADILQALDSI" }, { "InterPro": [ { "InterPro-ID": "IPR051131", "InterPro-Name": "NEK_Ser/Thr_kinase_NIMA", "InterPro-Type": "FAMILY", "Beg": 104, "End": 743 }, { "InterPro-ID": "IPR008271", "InterPro-Name": "Ser/Thr_kinase_AS", "InterPro-Type": "ACTIVE_SITE", "Beg": 236, "End": 248 }, { "InterPro-ID": "IPR000719", "InterPro-Name": "Prot_kinase_dom", "InterPro-Type": "DOMAIN", "Beg": 106, "End": 376 }, { "InterPro-ID": "IPR000719", "InterPro-Name": "Prot_kinase_dom", "InterPro-Type": "DOMAIN", "Beg": 106, "End": 380 }, { "InterPro-ID": "IPR011009", "InterPro-Name": "Kinase-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 103, "End": 459 } ], "response#1": "MEQFGGPSGFMPPASYTAPLGKYPTKQPSAAYPSDGGRHATKENPRPAEGQASRQSSSVPSAMASKPIQDPEGHSAQPTSSYCRAQTPRSTPLPVALDEEARLSQYEVIRQIGAGRFGEVFIIRHKATKALLCWKLVFYKGLREKEKKQLVSEVNVMRELRHANIVRYHDRIVCRSRQCLYIVMEYCDAGDLAKQIEAAHKHHGGIDQDRIVLVVVQLIHALAYCHEGVGQERRRVLHRDLKPCNIFLASHPEYPDDSSRCIAKLGDFGLSRHLNMHSMAHSCVGTPYYWSPELLEDGQKTYNVKSDMWALGCVIYEMCTGKTPFAQAQTMPQLKERVRCGPVLPVPGFSDSLNALMASLLQPNPNNRPSALQCLGYTIFRGCSYTPPPLYRSSSAPSWTPRNASPARGSPSSAVSTVSTVTTSPGSSSRTSFSAPSSHDAAASSPASASASSRYQHQRSSSYSSDSAGPSGASAPSQKAPGPGRPPETPSRESFDLASKARPGFFAEAPPPHAFAEASPPESHASEFLPPANGAANEARNERTQRDRTRRAASATAAAAVSAFERQQREGRSMSPDPSAPLASIEEEEEGEGDDAGCGSLGSGSGVTRRMPGASLNREDRREAPGLRHADTHKRDDRDGAIWTGRREEAPFSRPGSELARDFGAASQNKVDTSRFSGASSGKPRPGNPQNEDRASFASDTSARQTVYLSGLSRRCSEPPAAFHSAVSPWDPAPPRLSSAASSSSSSRAVSPSSLRRASSREMKYPTDDRPAVAAGSSGVALARAERGPEPGAPWGNEETEGLHVHGRPSAAPASSFSSERTSRPGHPDEARESEHCFQGRGRFAEAEASPATEGKDPRDSGFEERSGRRDEGRTDGGEAQSFGYWPNGRSDEARDRLGAPSVSPFSSKRITRRSSTAAGLSTYASPSDPAPSARAPAEWRRGAAGSSTVSAAGACGRFLPSPRSWQGNEKSFPSSSDHPSAYPALPHPAAPAYPEPGAQASNQFPRRRQSAFPSVKRLDYEEEHASSACLPTLLSPRFPHHPVSRPAGGVSPRSSQRQALAPTLAGMTFERRLSAGPLSSAPFSAPQERTTRLVGHRHALAADAERAEAPFSHAFRPGHHDRTPVGARRVPPRAETPGVSLDPGFRTGGPLDRGPVGSGGLEGQSFDFAHPTHASSEKKEAETEWSNPTAPVFYSPRSPRNDLPPGDGARSPYSAHLRPGVSEACSSFSVPPTERYEDDKNSHHAGSGGAFSPPTFGSPTPGPVPVGNERTFGRNPSPAATCASFSAKTGLRTPAPNGLAGDSGAFRSTNSLQRTPMSRRVSAPFGAGSAEGATAFGSRYASSGSFSKKFPQGSSSGVHEGGGAFGRRQEGDVSRVDAHGSVSPRSFSFLQRSDAPLSRGQPEGSHFQKHGETRASPDFARKGDSTQTHASGGRDFSQSGPFETQDFTFGEQPTRETRHMAPSPRGIERGGPQGSFVGHDTSFSVYAPRAGHAEGVESGCSAFEAPSESLSRRDGEADRENTVPNANGQMPVSGMPASKQTYGDDCDLYDNSAWTAQKHAPENFHAAVAPYPSSLLTGFAEGQQKAASRSSCLGGDR", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Prot_kinase_dom, Prot_kinase_dom that are essential for its biological function; 2. The protein should belong to NEK_Ser/Thr_kinase_NIMA that shares evolutionary origin and functional similarity; 3. The protein should be classified within Kinase-like_dom_sf sharing conserved structural features; 4. The protein must have Ser/Thr_kinase_AS that is conserved among related catalytic enzymes. The designed protein sequence is ", "reference": "MEQFGGPSGFMPPASYTAPLGKYPTKQPSAAYPSDGGRHATKENPRPAEGQASRQSSSVPSAMASKPIQDPEGHSAQPTSSYCRAQTPRSTPLPVALDEEARLSQYEVIRQIGAGRFGEVFIIRHKATKALLCWKLVFYKGLREKEKKQLVSEVNVMRELRHANIVRYHDRIVCRSRQCLYIVMEYCDAGDLAKQIEAAHKHHGGIDQDRIVLVVVQLIHALAYCHEGVGQERRRVLHRDLKPCNIFLASHPEYPDDSSRCIAKLGDFGLSRHLNMHSMAHSCVGTPYYWSPELLEDGQKTYNVKSDMWALGCVIYEMCTGKTPFAQAQTMPQLKERVRCGPVLPVPGFSDSLNALMASLLQPNPNNRPSALQCLGYTIFRGCSYTPPPLYRSSSAPSWTPRNASPARGSPSSAVSTVSTVTTSPGSSSRTSFSAPSSHDAAASSPASASASSRYQHQRSSSYSSDSAGPSGASAPSQKAPGPGRPPETPSRESFDLASKARPGFFAEAPPPHAFAEASPPESHASEFLPPANGAANEARNERTQRDRTRRAASATAAAAVSAFERQQREGRSMSPDPSAPLASIEEEEEGEGDDAGCGSLGSGSGVTRRMPGASLNREDRREAPGLRHADTHKRDDRDGAIWTGRREEAPFSRPGSELARDFGAASQNKVDTSRFSGASSGKPRPGNPQNEDRASFASDTSARQTVYLSGLSRRCSEPPAAFHSAVSPWDPAPPRLSSAASSSSSSRAVSPSSLRRASSREMKYPTDDRPAVAAGSSGVALARAERGPEPGAPWGNEETEGLHVHGRPSAAPASSFSSERTSRPGHPDEARESEHCFQGRGRFAEAEASPATEGKDPRDSGFEERSGRRDEGRTDGGEAQSFGYWPNGRSDEARDRLGAPSVSPFSSKRITRRSSTAAGLSTYASPSDPAPSARAPAEWRRGAAGSSTVSAAGACGRFLPSPRSWQGNEKSFPSSSDHPSAYPALPHPAAPAYPEPGAQASNQFPRRRQSAFPSVKRLDYEEEHASSACLPTLLSPRFPHHPVSRPAGGVSPRSSQRQALAPTLAGMTFERRLSAGPLSSAPFSAPQERTTRLVGHRHALAADAERAEAPFSHAFRPGHHDRTPVGARRVPPRAETPGVSLDPGFRTGGPLDRGPVGSGGLEGQSFDFAHPTHASSEKKEAETEWSNPTAPVFYSPRSPRNDLPPGDGARSPYSAHLRPGVSEACSSFSVPPTERYEDDKNSHHAGSGGAFSPPTFGSPTPGPVPVGNERTFGRNPSPAATCASFSAKTGLRTPAPNGLAGDSGAFRSTNSLQRTPMSRRVSAPFGAGSAEGATAFGSRYASSGSFSKKFPQGSSSGVHEGGGAFGRRQEGDVSRVDAHGSVSPRSFSFLQRSDAPLSRGQPEGSHFQKHGETRASPDFARKGDSTQTHASGGRDFSQSGPFETQDFTFGEQPTRETRHMAPSPRGIERGGPQGSFVGHDTSFSVYAPRAGHAEGVESGCSAFEAPSESLSRRDGEADRENTVPNANGQMPVSGMPASKQTYGDDCDLYDNSAWTAQKHAPENFHAAVAPYPSSLLTGFAEGQQKAASRSSCLGGDR" }, { "InterPro": [ { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 30, "End": 104 }, { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 30, "End": 107 } ], "response#1": "MFSRVMFCTFLILPLLAAATAIPRTDTPSCSTGSLQCCSSVQKASDPLVGIIVALLGIVLGPLDLNVGLTCSPITVIGVGGTSCTQQTVCCTGNNFDGLIVAGCSPINIGL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Hydrophobin, Hydrophobin that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MFSRVMFCTFLILPLLAAATAIPRTDTPSCSTGSLQCCSSVQKASDPLVGIIVALLGIVLGPLDLNVGLTCSPITVIGVGGTSCTQQTVCCTGNNFDGLIVAGCSPINIGL" }, { "InterPro": [ { "InterPro-ID": "IPR019778", "InterPro-Name": "Hydrophobin_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 78, "End": 89 }, { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 28, "End": 104 }, { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 28, "End": 101 } ], "response#1": "MFFQTTIVAALASLAVATPLALRTDSRCNTESVKCCNKSEDAETFKKSASAALIPIKIGDITGEVYSECSPIVGLIGGSSCSAQTVCCDNAKFNGLVNIGCTPINVAL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Hydrophobin, Hydrophobin that shares evolutionary origin and functional similarity; 2. The protein should contain Hydrophobin_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MFFQTTIVAALASLAVATPLALRTDSRCNTESVKCCNKSEDAETFKKSASAALIPIKIGDITGEVYSECSPIVGLIGGSSCSAQTVCCDNAKFNGLVNIGCTPINVAL" }, { "InterPro": [ { "InterPro-ID": "IPR013216", "InterPro-Name": "Methyltransf_11", "InterPro-Type": "DOMAIN", "Beg": 72, "End": 170 }, { "InterPro-ID": "IPR025774", "InterPro-Name": "MTs_g-TMT", "InterPro-Type": "FAMILY", "Beg": 1, "End": 196 }, { "InterPro-ID": "IPR029063", "InterPro-Name": "SAM-dependent_MTases_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 9, "End": 289 }, { "InterPro-ID": "IPR029063", "InterPro-Name": "SAM-dependent_MTases_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 8, "End": 289 } ], "response#1": "MAENQEALAEFYDKGVGVWDNLSREHMHFGYYAPGATATIGGHRASLVRLIDEALCFAEFPDDPEKKPRNMLDVGCGIGGTCLHVAKKYDIQCKGINISPEQVKIAQGLAAAQGLESKVSFDVGDALDMPYPDGAFDLVLSIHCIEHLQDKEKFIREMVRVAASGATIIILSHVHRDLSPSEQSLKPQEERVLRKIGSSVQAWFCPLSNYVSLLAPLPVEVIKIADWSRNIDPSSRLMLKVAFSVKGIVSNLMKGVQGWTAIKNVLPMKLLHKALHDGLVKFVVLTCRKSN", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Methyltransf_11 that are essential for its biological function; 2. The protein should belong to MTs_g-TMT that shares evolutionary origin and functional similarity; 3. The protein should be classified within SAM-dependent_MTases_sf, SAM-dependent_MTases_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MAENQEALAEFYDKGVGVWDNLSREHMHFGYYAPGATATIGGHRASLVRLIDEALCFAEFPDDPEKKPRNMLDVGCGIGGTCLHVAKKYDIQCKGINISPEQVKIAQGLAAAQGLESKVSFDVGDALDMPYPDGAFDLVLSIHCIEHLQDKEKFIREMVRVAASGATIIILSHVHRDLSPSEQSLKPQEERVLRKIGSSVQAWFCPLSNYVSLLAPLPVEVIKIADWSRNIDPSSRLMLKVAFSVKGIVSNLMKGVQGWTAIKNVLPMKLLHKALHDGLVKFVVLTCRKSN" }, { "InterPro": [ { "InterPro-ID": "IPR002919", "InterPro-Name": "TIL_dom", "InterPro-Type": "DOMAIN", "Beg": 43, "End": 104 }, { "InterPro-ID": "IPR036084", "InterPro-Name": "Ser_inhib-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 41, "End": 105 }, { "InterPro-ID": "IPR051368", "InterPro-Name": "SerProtInhib-TIL_Domain", "InterPro-Type": "FAMILY", "Beg": 41, "End": 107 } ], "response#1": "MKMKLLQVHFVLLVSSSFLLGYTGMVTAAILSRPQVVFVEDTCRENEIFSQCQASPNCEKSCDNIDIWESVPCIQTKSCVSGCICEDGYVRDKNQGVCILENSCPRVRH", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more TIL_dom that are essential for its biological function; 2. The protein should belong to SerProtInhib-TIL_Domain that shares evolutionary origin and functional similarity; 3. The protein should be classified within Ser_inhib-like_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MKMKLLQVHFVLLVSSSFLLGYTGMVTAAILSRPQVVFVEDTCRENEIFSQCQASPNCEKSCDNIDIWESVPCIQTKSCVSGCICEDGYVRDKNQGVCILENSCPRVRH" }, { "InterPro": [ { "InterPro-ID": "IPR036084", "InterPro-Name": "Ser_inhib-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 24, "End": 84 }, { "InterPro-ID": "IPR002919", "InterPro-Name": "TIL_dom", "InterPro-Type": "DOMAIN", "Beg": 26, "End": 83 } ], "response#1": "MFRFVCVLFIALVVFCTTTSAGELVCNRPNEEYRCGSACQTTCATLGQRCPIMNIRCNDACYCKEGYARYGDDTGMCVSISQCNSKRSAIAQILRSKQLSKNSGV", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more TIL_dom that are essential for its biological function; 2. The protein should be classified within Ser_inhib-like_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MFRFVCVLFIALVVFCTTTSAGELVCNRPNEEYRCGSACQTTCATLGQRCPIMNIRCNDACYCKEGYARYGDDTGMCVSISQCNSKRSAIAQILRSKQLSKNSGV" }, { "InterPro": [ { "InterPro-ID": "IPR004169", "InterPro-Name": "Spidertoxin", "InterPro-Type": "FAMILY", "Beg": 33, "End": 68 }, { "InterPro-ID": "IPR004169", "InterPro-Name": "Spidertoxin", "InterPro-Type": "FAMILY", "Beg": 34, "End": 68 } ], "response#1": "MKEANTRRYIYLCLVVVLLSIIITTEAEDDRLFCIRHHKYCGHRPKRCCSGLFCRCNTFGTNCRCQSKGALGKLI", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Spidertoxin, Spidertoxin that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MKEANTRRYIYLCLVVVLLSIIITTEAEDDRLFCIRHHKYCGHRPKRCCSGLFCRCNTFGTNCRCQSKGALGKLI" }, { "InterPro": [ { "InterPro-ID": "IPR004169", "InterPro-Name": "Spidertoxin", "InterPro-Type": "FAMILY", "Beg": 78, "End": 113 }, { "InterPro-ID": "IPR004169", "InterPro-Name": "Spidertoxin", "InterPro-Type": "FAMILY", "Beg": 79, "End": 113 } ], "response#1": "MISKILIAACALLLISHLVLAVPYLEDGLNSLHNRTGESDETRGYTIQLLKEMPEDDAVEDYSADNLERLLQNTQKRSCIRRFGRCDHRPNDCCYNSSCRCNLWGSNCRCQRMGLFQKWG", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Spidertoxin, Spidertoxin that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MISKILIAACALLLISHLVLAVPYLEDGLNSLHNRTGESDETRGYTIQLLKEMPEDDAVEDYSADNLERLLQNTQKRSCIRRFGRCDHRPNDCCYNSSCRCNLWGSNCRCQRMGLFQKWG" }, { "InterPro": [ { "InterPro-ID": "IPR013216", "InterPro-Name": "Methyltransf_11", "InterPro-Type": "DOMAIN", "Beg": 74, "End": 171 }, { "InterPro-ID": "IPR029063", "InterPro-Name": "SAM-dependent_MTases_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 17, "End": 290 }, { "InterPro-ID": "IPR025774", "InterPro-Name": "MTs_g-TMT", "InterPro-Type": "FAMILY", "Beg": 1, "End": 292 }, { "InterPro-ID": "IPR029063", "InterPro-Name": "SAM-dependent_MTases_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 5, "End": 290 } ], "response#1": "MAEKQQAVTEFYNNTSPRGAWEFLLGDHLHEGFYDPGTTATISGSQAAAARMIDEALRFANIYDDPSKKPKNMLDIGCGVGGTCVHVAKQYGIQCKGITLSPEEVKCAQGIAKAQGLEEKVSFDVGDALNLPYKDGTFDLVLTIECIEHVQDKEKFIREMIRVAAPGAPIVILSYAHRNLSPSAESLKPDEKKVLKKICDNLALSCLCSSADFVRWLTQLPAEDIKTADWTQNTSPFFPLLMKETFTWKGFTSLLMKGGWTAIKELLALRMMSKAADDGLLKFVAITCRKSK", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Methyltransf_11 that are essential for its biological function; 2. The protein should belong to MTs_g-TMT that shares evolutionary origin and functional similarity; 3. The protein should be classified within SAM-dependent_MTases_sf, SAM-dependent_MTases_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MAEKQQAVTEFYNNTSPRGAWEFLLGDHLHEGFYDPGTTATISGSQAAAARMIDEALRFANIYDDPSKKPKNMLDIGCGVGGTCVHVAKQYGIQCKGITLSPEEVKCAQGIAKAQGLEEKVSFDVGDALNLPYKDGTFDLVLTIECIEHVQDKEKFIREMIRVAAPGAPIVILSYAHRNLSPSAESLKPDEKKVLKKICDNLALSCLCSSADFVRWLTQLPAEDIKTADWTQNTSPFFPLLMKETFTWKGFTSLLMKGGWTAIKELLALRMMSKAADDGLLKFVAITCRKSK" }, { "InterPro": [ { "InterPro-ID": "IPR047109", "InterPro-Name": "CAD-like", "InterPro-Type": "FAMILY", "Beg": 9, "End": 357 }, { "InterPro-ID": "IPR020843", "InterPro-Name": "PKS_ER", "InterPro-Type": "DOMAIN", "Beg": 24, "End": 352 }, { "InterPro-ID": "IPR036291", "InterPro-Name": "NAD(P)-bd_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 157, "End": 322 }, { "InterPro-ID": "IPR047109", "InterPro-Name": "CAD-like", "InterPro-Type": "FAMILY", "Beg": 16, "End": 353 }, { "InterPro-ID": "IPR011032", "InterPro-Name": "GroES-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 11, "End": 200 }, { "InterPro-ID": "IPR013149", "InterPro-Name": "ADH-like_C", "InterPro-Type": "DOMAIN", "Beg": 195, "End": 318 }, { "InterPro-ID": "IPR013154", "InterPro-Name": "ADH-like_N", "InterPro-Type": "DOMAIN", "Beg": 37, "End": 154 } ], "response#1": "MAGKSPEEQHPVKAYGWAARDSSGILSPFKFSRRATGDHDVRVKILYAGVCHSDLQSARNEMGCFTYPLVPGFETVGIATEVGSKVTKMKVGDKVAVGIMVGSCGKCDDCVNDRECYCPEVITSYGRIDHDGTPTYGGFSNETVANEKFVFRFPEKLPMAAGAPLLNAGVSVYSPMRFYGLDKPGMHLGVVGLGGLGHLAVKFAKAFGVKVTVISTSSIKKGEAINDLGADAFLVSTDAKQMQAGSGTLDGILDTVPVVHPIEPLLGLLKNHTKLVLVGATMGSFELPILPLGVGRKSVASTVGGSTTEAQEMLDFAAEHNITANVEIIPMDYINTAMERIEKNDVRYRFVIDVGNTLTPPES", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more PKS_ER, ADH-like_C, ADH-like_N that are essential for its biological function; 2. The protein should belong to CAD-like, CAD-like that shares evolutionary origin and functional similarity; 3. The protein should be classified within NAD(P)-bd_dom_sf, GroES-like_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MAGKSPEEQHPVKAYGWAARDSSGILSPFKFSRRATGDHDVRVKILYAGVCHSDLQSARNEMGCFTYPLVPGFETVGIATEVGSKVTKMKVGDKVAVGIMVGSCGKCDDCVNDRECYCPEVITSYGRIDHDGTPTYGGFSNETVANEKFVFRFPEKLPMAAGAPLLNAGVSVYSPMRFYGLDKPGMHLGVVGLGGLGHLAVKFAKAFGVKVTVISTSSIKKGEAINDLGADAFLVSTDAKQMQAGSGTLDGILDTVPVVHPIEPLLGLLKNHTKLVLVGATMGSFELPILPLGVGRKSVASTVGGSTTEAQEMLDFAAEHNITANVEIIPMDYINTAMERIEKNDVRYRFVIDVGNTLTPPES" }, { "InterPro": [ { "InterPro-ID": "IPR036259", "InterPro-Name": "MFS_trans_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 64, "End": 506 }, { "InterPro-ID": "IPR036259", "InterPro-Name": "MFS_trans_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 51, "End": 504 }, { "InterPro-ID": "IPR052599", "InterPro-Name": "SLC43A_AATransporter", "InterPro-Type": "FAMILY", "Beg": 329, "End": 534 } ], "response#1": "MASSDSNAKLASQRLHSCAGGEESSGQCLEKQGAGARLRGWLAQLLPRADLPGARQKTPFNLNRYVLLLLYSIVVFTTGAVFYGWTALSAMIFKNDGFAYLCPKDASGVYVPDLRATQGKLYICDEQDAAVQKLYTMTFAVACLMSAGAGTLLDWLGPLWTELLGQLLNLVGWLFLAFSTVDRPLYYPALVFIGLGADASMLPTLCIRHLFPGSTGLIITILGSAASASFGIPLVLNTIVENHGVSVRDVSIGYCFFGPVLGVLVALLFMPRRGFALDDAGTIFREPDSGEGEGEAGPYALENGAQGGESQNAQETRRRKLLDPIVSSSFWTQFFSIRYFLIVLYFVVVSWATSYYQQAARRMFSEDVVSVIEVLLPLSFIPCILLGKVADVVGIIRVLFVMNTSGLLTYVFSFFKTDATGYLSACCFMVYMSLLTSQVYVYVEGTFSPNHFGKLIGISNLTGGLLSLVSNPLYENITVNRDNGDPLCIQIAMTALLCVQYVWIFILGFLKSGNSPLLNMDVKAKDDADAEKRADNAPGAEERTSAPSGSSSELAAVTVTPPQDSA", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to SLC43A_AATransporter that shares evolutionary origin and functional similarity; 2. The protein should be classified within MFS_trans_sf, MFS_trans_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MASSDSNAKLASQRLHSCAGGEESSGQCLEKQGAGARLRGWLAQLLPRADLPGARQKTPFNLNRYVLLLLYSIVVFTTGAVFYGWTALSAMIFKNDGFAYLCPKDASGVYVPDLRATQGKLYICDEQDAAVQKLYTMTFAVACLMSAGAGTLLDWLGPLWTELLGQLLNLVGWLFLAFSTVDRPLYYPALVFIGLGADASMLPTLCIRHLFPGSTGLIITILGSAASASFGIPLVLNTIVENHGVSVRDVSIGYCFFGPVLGVLVALLFMPRRGFALDDAGTIFREPDSGEGEGEAGPYALENGAQGGESQNAQETRRRKLLDPIVSSSFWTQFFSIRYFLIVLYFVVVSWATSYYQQAARRMFSEDVVSVIEVLLPLSFIPCILLGKVADVVGIIRVLFVMNTSGLLTYVFSFFKTDATGYLSACCFMVYMSLLTSQVYVYVEGTFSPNHFGKLIGISNLTGGLLSLVSNPLYENITVNRDNGDPLCIQIAMTALLCVQYVWIFILGFLKSGNSPLLNMDVKAKDDADAEKRADNAPGAEERTSAPSGSSSELAAVTVTPPQDSA" }, { "InterPro": [ { "InterPro-ID": "IPR050117", "InterPro-Name": "MAP_kinase", "InterPro-Type": "FAMILY", "Beg": 21, "End": 332 }, { "InterPro-ID": "IPR000719", "InterPro-Name": "Prot_kinase_dom", "InterPro-Type": "DOMAIN", "Beg": 23, "End": 314 }, { "InterPro-ID": "IPR003527", "InterPro-Name": "MAP_kinase_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 58, "End": 161 }, { "InterPro-ID": "IPR008352", "InterPro-Name": "MAPK_p38-like", "InterPro-Type": "FAMILY", "Beg": 292, "End": 300 }, { "InterPro-ID": "IPR008352", "InterPro-Name": "MAPK_p38-like", "InterPro-Type": "FAMILY", "Beg": 276, "End": 289 }, { "InterPro-ID": "IPR008352", "InterPro-Name": "MAPK_p38-like", "InterPro-Type": "FAMILY", "Beg": 199, "End": 209 }, { "InterPro-ID": "IPR008352", "InterPro-Name": "MAPK_p38-like", "InterPro-Type": "FAMILY", "Beg": 313, "End": 323 }, { "InterPro-ID": "IPR017441", "InterPro-Name": "Protein_kinase_ATP_BS", "InterPro-Type": "BINDING_SITE", "Beg": 29, "End": 53 }, { "InterPro-ID": "IPR008271", "InterPro-Name": "Ser/Thr_kinase_AS", "InterPro-Type": "ACTIVE_SITE", "Beg": 145, "End": 157 }, { "InterPro-ID": "IPR011009", "InterPro-Name": "Kinase-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 15, "End": 320 } ], "response#1": "MADLQGRKVFKVFNQDFIVDERYTVTKELGQGAYGIVCAAVNNQTNEGVAIKKVTNVFSKKILAKRALREIKLLQHFRGHRNITCLYDMDIPRPDNFNETYLYEELMECDLAAIIRSGQPLTDAHFQSFIYQILCGLKYIHSANVLHRDLKPGNLLVNADCELKICDFGLARGFSIDPEENAGYMTEYVATRWYRAPEIMLSFQSYTKAIDVWSVGCILAELLGGRPFFKGRDYVDQLNQILHILGTPNEETLSRIGSPRAQEYVRNLPFMPKKPFAALFPNANPDALDLLDRMLAFDPSSRISVEEALEHPYLQIWHDASDEPDCPTTFNFDFEIVEDVGDMRKMILEEVFRFRQVVRTVAGENGGQQAGQQPGAGQVPMPSGGQGQWRTEDPRPEEYMGHNANGLEGELALGADGRR", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Prot_kinase_dom that are essential for its biological function; 2. The protein should belong to MAP_kinase, MAPK_p38-like, MAPK_p38-like, MAPK_p38-like, MAPK_p38-like that shares evolutionary origin and functional similarity; 3. The protein should be classified within Kinase-like_dom_sf sharing conserved structural features; 4. The protein should contain MAP_kinase_CS that is preserved across related proteins; 5. The protein must have Ser/Thr_kinase_AS that is conserved among related catalytic enzymes; 6. The protein should include a Protein_kinase_ATP_BS that enables ligand binding under diverse conditions. The designed protein sequence is ", "reference": "MADLQGRKVFKVFNQDFIVDERYTVTKELGQGAYGIVCAAVNNQTNEGVAIKKVTNVFSKKILAKRALREIKLLQHFRGHRNITCLYDMDIPRPDNFNETYLYEELMECDLAAIIRSGQPLTDAHFQSFIYQILCGLKYIHSANVLHRDLKPGNLLVNADCELKICDFGLARGFSIDPEENAGYMTEYVATRWYRAPEIMLSFQSYTKAIDVWSVGCILAELLGGRPFFKGRDYVDQLNQILHILGTPNEETLSRIGSPRAQEYVRNLPFMPKKPFAALFPNANPDALDLLDRMLAFDPSSRISVEEALEHPYLQIWHDASDEPDCPTTFNFDFEIVEDVGDMRKMILEEVFRFRQVVRTVAGENGGQQAGQQPGAGQVPMPSGGQGQWRTEDPRPEEYMGHNANGLEGELALGADGRR" }, { "InterPro": [ { "InterPro-ID": "IPR038783", "InterPro-Name": "MAPK_Sty1/Hog1", "InterPro-Type": "FAMILY", "Beg": 9, "End": 343 }, { "InterPro-ID": "IPR011009", "InterPro-Name": "Kinase-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 5, "End": 345 }, { "InterPro-ID": "IPR000719", "InterPro-Name": "Prot_kinase_dom", "InterPro-Type": "DOMAIN", "Beg": 20, "End": 306 }, { "InterPro-ID": "IPR008271", "InterPro-Name": "Ser/Thr_kinase_AS", "InterPro-Type": "ACTIVE_SITE", "Beg": 144, "End": 156 }, { "InterPro-ID": "IPR003527", "InterPro-Name": "MAP_kinase_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 55, "End": 160 }, { "InterPro-ID": "IPR050117", "InterPro-Name": "MAP_kinase", "InterPro-Type": "FAMILY", "Beg": 18, "End": 310 }, { "InterPro-ID": "IPR017441", "InterPro-Name": "Protein_kinase_ATP_BS", "InterPro-Type": "BINDING_SITE", "Beg": 26, "End": 50 } ], "response#1": "MAEFVRAQIFGTTFEITSRYSDLQPVGMGAFGLVCSARDQLTNQNVAVKKIMKPFSTPVLAKRTYRELKLLKHLKHENVISLSDIFISPLEDIVLRWGCSYFVTELLGTDLHRLLTSRPLEKQFIQYFLYQIMRGLKYVHSAGVVHRDLKPSNILVNENCDLKICDFGLARIQDPQMTGYVSTRYYRAPEIMLTWQKYDVEVDIWSAGCIFAEMLEGKPLFPGKDHVNQFSIITELLGTPPDDVINTIASENTLRFVKSLPKRERQSLKHKFKNADAPAIDLLESMLVFDPKKRITATNALAHEYLAPYHDPTDEPVAEEKFDWSFNDADLPVDTWKIMMYSEILDYHNVEAGVAAMEGQEFNGQ", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Prot_kinase_dom that are essential for its biological function; 2. The protein should belong to MAPK_Sty1/Hog1, MAP_kinase that shares evolutionary origin and functional similarity; 3. The protein should be classified within Kinase-like_dom_sf sharing conserved structural features; 4. The protein should contain MAP_kinase_CS that is preserved across related proteins; 5. The protein must have Ser/Thr_kinase_AS that is conserved among related catalytic enzymes; 6. The protein should include a Protein_kinase_ATP_BS that enables ligand binding under diverse conditions. The designed protein sequence is ", "reference": "MAEFVRAQIFGTTFEITSRYSDLQPVGMGAFGLVCSARDQLTNQNVAVKKIMKPFSTPVLAKRTYRELKLLKHLKHENVISLSDIFISPLEDIVLRWGCSYFVTELLGTDLHRLLTSRPLEKQFIQYFLYQIMRGLKYVHSAGVVHRDLKPSNILVNENCDLKICDFGLARIQDPQMTGYVSTRYYRAPEIMLTWQKYDVEVDIWSAGCIFAEMLEGKPLFPGKDHVNQFSIITELLGTPPDDVINTIASENTLRFVKSLPKRERQSLKHKFKNADAPAIDLLESMLVFDPKKRITATNALAHEYLAPYHDPTDEPVAEEKFDWSFNDADLPVDTWKIMMYSEILDYHNVEAGVAAMEGQEFNGQ" }, { "InterPro": [ { "InterPro-ID": "IPR018865", "InterPro-Name": "STK19-like", "InterPro-Type": "FAMILY", "Beg": 31, "End": 257 }, { "InterPro-ID": "IPR018865", "InterPro-Name": "STK19-like", "InterPro-Type": "FAMILY", "Beg": 58, "End": 256 } ], "response#1": "MDRKRKLICDAFKVKKLRGSCSRDETDLKTSTSPYPDFTEDPHGAVSYLCALFPRKLFNDTLPPLFLKHQLYSLMQDRTVVDRLLSSLQQKGEVCLVQTGFDLDTFMVVMTDDLRRTALSSSEGDSRATVVRKFLDCDLLLSPNISYGRDEMMMKHRFSDGEITQLVRAGLLTVRDAGSWWLAVPGAGRFITHFIKGRKALLSQIRRSRYKEVLLTDLSTRKAPPNLRLGMEFHIHDIIGAGLVDCVPTASGILLRISET", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to STK19-like, STK19-like that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MDRKRKLICDAFKVKKLRGSCSRDETDLKTSTSPYPDFTEDPHGAVSYLCALFPRKLFNDTLPPLFLKHQLYSLMQDRTVVDRLLSSLQQKGEVCLVQTGFDLDTFMVVMTDDLRRTALSSSEGDSRATVVRKFLDCDLLLSPNISYGRDEMMMKHRFSDGEITQLVRAGLLTVRDAGSWWLAVPGAGRFITHFIKGRKALLSQIRRSRYKEVLLTDLSTRKAPPNLRLGMEFHIHDIIGAGLVDCVPTASGILLRISET" }, { "InterPro": [ { "InterPro-ID": "IPR050546", "InterPro-Name": "Glycosyl_Hydrlase_16", "InterPro-Type": "FAMILY", "Beg": 20, "End": 245 }, { "InterPro-ID": "IPR013320", "InterPro-Name": "ConA-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 57, "End": 244 }, { "InterPro-ID": "IPR000757", "InterPro-Name": "GH16", "InterPro-Type": "DOMAIN", "Beg": 1, "End": 229 }, { "InterPro-ID": "IPR017168", "InterPro-Name": "Glyco_hydro_16_CRH1_prd", "InterPro-Type": "FAMILY", "Beg": 1, "End": 348 }, { "InterPro-ID": "IPR000757", "InterPro-Name": "GH16", "InterPro-Type": "DOMAIN", "Beg": 59, "End": 222 } ], "response#1": "MFPKIFLTAATALLSAKSTFAQTYSSCNPLFTTGCPANTALGKSIDVDFTSGSVNSFDGSGDITYDSNGASFTVAKSGDAPTLSSIFYIMFGKVQITMKAAPGAGIVSTLVLQSDDLDEIDMEWLGADDTEVQTNYFGKGKVTDYNRGAFNPAANNQGEFITYTIEWTSEQVVWSVGSTVVRVLTPATADTDQYPQSPMQIKFGAWSGGDSSNAAGTISWARGPTDYSNGPFTMVVQSIDVSDYSTGTQYKYGDQSGDWTSIEAIGGSVNGNVPASASSIQTAGAAAVTSSSPTIPAGINNGNSATRTGYPWVAGTQTVSEVTWSTGPSIPSGWEISSEGKIVPVSASPINISRINPLLLCGPFTFFFFAAIRRWP", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more GH16, GH16 that are essential for its biological function; 2. The protein should belong to Glycosyl_Hydrlase_16, Glyco_hydro_16_CRH1_prd that shares evolutionary origin and functional similarity; 3. The protein should be classified within ConA-like_dom_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MFPKIFLTAATALLSAKSTFAQTYSSCNPLFTTGCPANTALGKSIDVDFTSGSVNSFDGSGDITYDSNGASFTVAKSGDAPTLSSIFYIMFGKVQITMKAAPGAGIVSTLVLQSDDLDEIDMEWLGADDTEVQTNYFGKGKVTDYNRGAFNPAANNQGEFITYTIEWTSEQVVWSVGSTVVRVLTPATADTDQYPQSPMQIKFGAWSGGDSSNAAGTISWARGPTDYSNGPFTMVVQSIDVSDYSTGTQYKYGDQSGDWTSIEAIGGSVNGNVPASASSIQTAGAAAVTSSSPTIPAGINNGNSATRTGYPWVAGTQTVSEVTWSTGPSIPSGWEISSEGKIVPVSASPINISRINPLLLCGPFTFFFFAAIRRWP" }, { "InterPro": [ { "InterPro-ID": "IPR000757", "InterPro-Name": "GH16", "InterPro-Type": "DOMAIN", "Beg": 62, "End": 227 }, { "InterPro-ID": "IPR013320", "InterPro-Name": "ConA-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 24, "End": 250 }, { "InterPro-ID": "IPR050546", "InterPro-Name": "Glycosyl_Hydrlase_16", "InterPro-Type": "FAMILY", "Beg": 14, "End": 250 }, { "InterPro-ID": "IPR000757", "InterPro-Name": "GH16", "InterPro-Type": "DOMAIN", "Beg": 21, "End": 241 } ], "response#1": "MQFNSLVLLAGATILSPFVQAQTWTTCNPLNETCPNDPALGTNHTFVFNTSSTVTDYYNITAGSLTYGDDGAEFTIAKQGQSPTIQSKFYIFFGQVSVIMKAATGVGIVSSIVLESDDLDEIDWEFIGGNDTHAETNYFGKGNTTSYDRAIWYPTPSDPTANFHNYTVDWTAERVQWWIDDSLVRTLAYADAVDGKNFPQTPMTVRLGIWSGGDPKGNSQGTIEWAGGETDFTKVPFTMYVKSAAVQDYSTGSEYEWTDKTGDWTSIKVISGNSTVAETITKNETPTLSLGEKWDNLPKTTKLAVYCGGGAAVAALVSAFLFTFLRQRRNGRLEREAYNQLIEKQQQDAYKDQMELHNKGIGGFDNNSYATQGDDALGGWGSNQGTGYVGPSGSASAMASGSPMVQAGQHGPMSPTMVMRNGEMSPHSAEFPQPQQPMFGGSANGGSYMKM", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more GH16, GH16 that are essential for its biological function; 2. The protein should belong to Glycosyl_Hydrlase_16 that shares evolutionary origin and functional similarity; 3. The protein should be classified within ConA-like_dom_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MQFNSLVLLAGATILSPFVQAQTWTTCNPLNETCPNDPALGTNHTFVFNTSSTVTDYYNITAGSLTYGDDGAEFTIAKQGQSPTIQSKFYIFFGQVSVIMKAATGVGIVSSIVLESDDLDEIDWEFIGGNDTHAETNYFGKGNTTSYDRAIWYPTPSDPTANFHNYTVDWTAERVQWWIDDSLVRTLAYADAVDGKNFPQTPMTVRLGIWSGGDPKGNSQGTIEWAGGETDFTKVPFTMYVKSAAVQDYSTGSEYEWTDKTGDWTSIKVISGNSTVAETITKNETPTLSLGEKWDNLPKTTKLAVYCGGGAAVAALVSAFLFTFLRQRRNGRLEREAYNQLIEKQQQDAYKDQMELHNKGIGGFDNNSYATQGDDALGGWGSNQGTGYVGPSGSASAMASGSPMVQAGQHGPMSPTMVMRNGEMSPHSAEFPQPQQPMFGGSANGGSYMKM" }, { "InterPro": [ { "InterPro-ID": "IPR018247", "InterPro-Name": "EF_Hand_1_Ca_BS", "InterPro-Type": "BINDING_SITE", "Beg": 50, "End": 62 }, { "InterPro-ID": "IPR011992", "InterPro-Name": "EF-hand-dom_pair", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 20, "End": 106 }, { "InterPro-ID": "IPR018247", "InterPro-Name": "EF_Hand_1_Ca_BS", "InterPro-Type": "BINDING_SITE", "Beg": 89, "End": 101 }, { "InterPro-ID": "IPR002048", "InterPro-Name": "EF_hand_dom", "InterPro-Type": "DOMAIN", "Beg": 37, "End": 72 }, { "InterPro-ID": "IPR008080", "InterPro-Name": "Parvalbumin", "InterPro-Type": "FAMILY", "Beg": 2, "End": 106 }, { "InterPro-ID": "IPR002048", "InterPro-Name": "EF_hand_dom", "InterPro-Type": "DOMAIN", "Beg": 80, "End": 107 }, { "InterPro-ID": "IPR002048", "InterPro-Name": "EF_hand_dom", "InterPro-Type": "DOMAIN", "Beg": 41, "End": 69 }, { "InterPro-ID": "IPR002048", "InterPro-Name": "EF_hand_dom", "InterPro-Type": "DOMAIN", "Beg": 41, "End": 105 } ], "response#1": "GSITTVLNATDIAKALAQCAGSFNHKTFFVTSGLTNKSDANLAKVFDILDQDRSGFIEVDELKLFLQNFSATARELDETETNAFLAAGDSDHDGKIGVDEFKAMVKA", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more EF_hand_dom, EF_hand_dom, EF_hand_dom, EF_hand_dom that are essential for its biological function; 2. The protein should belong to Parvalbumin that shares evolutionary origin and functional similarity; 3. The protein should be classified within EF-hand-dom_pair sharing conserved structural features; 4. The protein should include a EF_Hand_1_Ca_BS, EF_Hand_1_Ca_BS that enables ligand binding under diverse conditions. The designed protein sequence is ", "reference": "GSITTVLNATDIAKALAQCAGSFNHKTFFVTSGLTNKSDANLAKVFDILDQDRSGFIEVDELKLFLQNFSATARELDETETNAFLAAGDSDHDGKIGVDEFKAMVKA" }, { "InterPro": [ { "InterPro-ID": "IPR017441", "InterPro-Name": "Protein_kinase_ATP_BS", "InterPro-Type": "BINDING_SITE", "Beg": 133, "End": 163 }, { "InterPro-ID": "IPR000719", "InterPro-Name": "Prot_kinase_dom", "InterPro-Type": "DOMAIN", "Beg": 127, "End": 644 }, { "InterPro-ID": "IPR011009", "InterPro-Name": "Kinase-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 116, "End": 646 }, { "InterPro-ID": "IPR000719", "InterPro-Name": "Prot_kinase_dom", "InterPro-Type": "DOMAIN", "Beg": 465, "End": 644 }, { "InterPro-ID": "IPR000719", "InterPro-Name": "Prot_kinase_dom", "InterPro-Type": "DOMAIN", "Beg": 128, "End": 280 }, { "InterPro-ID": "IPR008271", "InterPro-Name": "Ser/Thr_kinase_AS", "InterPro-Type": "ACTIVE_SITE", "Beg": 246, "End": 258 } ], "response#1": "MADRVMCQELATPGSHYRRPKTGVPSTNVVYANGGGSWRAAPRQTQRLPRQTVQQYATGTPATGSAGRHSGRAFATAGATEEQTVEFNGAAVMGLPATPRTTKQARNKSEEAINDLLTRIPDIGKLFDVHSRIGNGTFSTVLLGTLRRESHLPDSLRRKFAIKHHIPTSHPDRIMKELQCMTKMGGKENVVGIHCCMRYDASAAFVMPFMAHDRFQDFYTRMDVPEIRQYMRNLLVALRHVHKFDVIHRDVKPSNFLYNRRRREFLLVDFGLAQHVNPPAARSSGSAAAIAAANNKNNNNNNNNNSKRPRERESKGDVQQIALDAGLGGAVKRMRLHEESNKMPLKPVNDIAPSDAPEQSVDGSNHVQPQLVQQEQQQLQPQQQQQQQQQQQQSQQQQQPQQQSQQQHPQRQPQLAQMDQTASTPSGSKYNTNRNVSAAAANNAKCVCFANPSVCLNCLMKKEVHASRAGTPGYRPPEVLLKYPDQTTAVDVWAAGVIFLSIMSTVYPFFKAPNDFIALAEIVTIFGDQAIRKTALALDRMITLSQRSRPLNLRKLCLRFRYRSVFSDAKLLKSYESVDGSCEVCRNCDQYFFNCLCEDSDYLTEPLDAYECFPPSAYDLLDRLLEINPHKRITAEEALKHPFFTAAEEAEQTEQDQLANGTPRKMRRQRYQSHRTVAASQEQVKQQVALDLQQAAINKL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Prot_kinase_dom, Prot_kinase_dom, Prot_kinase_dom that are essential for its biological function; 2. The protein should be classified within Kinase-like_dom_sf sharing conserved structural features; 3. The protein must have Ser/Thr_kinase_AS that is conserved among related catalytic enzymes; 4. The protein should include a Protein_kinase_ATP_BS that enables ligand binding under diverse conditions. The designed protein sequence is ", "reference": "MADRVMCQELATPGSHYRRPKTGVPSTNVVYANGGGSWRAAPRQTQRLPRQTVQQYATGTPATGSAGRHSGRAFATAGATEEQTVEFNGAAVMGLPATPRTTKQARNKSEEAINDLLTRIPDIGKLFDVHSRIGNGTFSTVLLGTLRRESHLPDSLRRKFAIKHHIPTSHPDRIMKELQCMTKMGGKENVVGIHCCMRYDASAAFVMPFMAHDRFQDFYTRMDVPEIRQYMRNLLVALRHVHKFDVIHRDVKPSNFLYNRRRREFLLVDFGLAQHVNPPAARSSGSAAAIAAANNKNNNNNNNNNSKRPRERESKGDVQQIALDAGLGGAVKRMRLHEESNKMPLKPVNDIAPSDAPEQSVDGSNHVQPQLVQQEQQQLQPQQQQQQQQQQQQSQQQQQPQQQSQQQHPQRQPQLAQMDQTASTPSGSKYNTNRNVSAAAANNAKCVCFANPSVCLNCLMKKEVHASRAGTPGYRPPEVLLKYPDQTTAVDVWAAGVIFLSIMSTVYPFFKAPNDFIALAEIVTIFGDQAIRKTALALDRMITLSQRSRPLNLRKLCLRFRYRSVFSDAKLLKSYESVDGSCEVCRNCDQYFFNCLCEDSDYLTEPLDAYECFPPSAYDLLDRLLEINPHKRITAEEALKHPFFTAAEEAEQTEQDQLANGTPRKMRRQRYQSHRTVAASQEQVKQQVALDLQQAAINKL" }, { "InterPro": [ { "InterPro-ID": "IPR031766", "InterPro-Name": "RRM_occluded", "InterPro-Type": "DOMAIN", "Beg": 598, "End": 673 }, { "InterPro-ID": "IPR012677", "InterPro-Name": "Nucleotide-bd_a/b_plait_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 303, "End": 383 }, { "InterPro-ID": "IPR031766", "InterPro-Name": "RRM_occluded", "InterPro-Type": "DOMAIN", "Beg": 598, "End": 667 }, { "InterPro-ID": "IPR012677", "InterPro-Name": "Nucleotide-bd_a/b_plait_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 466, "End": 592 }, { "InterPro-ID": "IPR000504", "InterPro-Name": "RRM_dom", "InterPro-Type": "DOMAIN", "Beg": 386, "End": 463 }, { "InterPro-ID": "IPR000504", "InterPro-Name": "RRM_dom", "InterPro-Type": "DOMAIN", "Beg": 310, "End": 385 }, { "InterPro-ID": "IPR000504", "InterPro-Name": "RRM_dom", "InterPro-Type": "DOMAIN", "Beg": 478, "End": 550 }, { "InterPro-ID": "IPR000504", "InterPro-Name": "RRM_dom", "InterPro-Type": "DOMAIN", "Beg": 311, "End": 381 }, { "InterPro-ID": "IPR000504", "InterPro-Name": "RRM_dom", "InterPro-Type": "DOMAIN", "Beg": 594, "End": 666 }, { "InterPro-ID": "IPR000504", "InterPro-Name": "RRM_dom", "InterPro-Type": "DOMAIN", "Beg": 387, "End": 459 }, { "InterPro-ID": "IPR035979", "InterPro-Name": "RBD_domain_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 306, "End": 463 }, { "InterPro-ID": "IPR000504", "InterPro-Name": "RRM_dom", "InterPro-Type": "DOMAIN", "Beg": 598, "End": 670 }, { "InterPro-ID": "IPR003954", "InterPro-Name": "RRM_dom_euk", "InterPro-Type": "DOMAIN", "Beg": 387, "End": 458 }, { "InterPro-ID": "IPR003954", "InterPro-Name": "RRM_dom_euk", "InterPro-Type": "DOMAIN", "Beg": 478, "End": 550 }, { "InterPro-ID": "IPR003954", "InterPro-Name": "RRM_dom_euk", "InterPro-Type": "DOMAIN", "Beg": 311, "End": 381 }, { "InterPro-ID": "IPR012677", "InterPro-Name": "Nucleotide-bd_a/b_plait_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 386, "End": 465 }, { "InterPro-ID": "IPR000504", "InterPro-Name": "RRM_dom", "InterPro-Type": "DOMAIN", "Beg": 480, "End": 544 }, { "InterPro-ID": "IPR000504", "InterPro-Name": "RRM_dom", "InterPro-Type": "DOMAIN", "Beg": 388, "End": 453 }, { "InterPro-ID": "IPR000504", "InterPro-Name": "RRM_dom", "InterPro-Type": "DOMAIN", "Beg": 312, "End": 378 }, { "InterPro-ID": "IPR034397", "InterPro-Name": "Prp24_RRM1", "InterPro-Type": "DOMAIN", "Beg": 310, "End": 381 }, { "InterPro-ID": "IPR000504", "InterPro-Name": "RRM_dom", "InterPro-Type": "DOMAIN", "Beg": 477, "End": 554 }, { "InterPro-ID": "IPR034398", "InterPro-Name": "Prp24_RRM2", "InterPro-Type": "DOMAIN", "Beg": 386, "End": 463 }, { "InterPro-ID": "IPR035979", "InterPro-Name": "RBD_domain_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 475, "End": 667 }, { "InterPro-ID": "IPR012677", "InterPro-Name": "Nucleotide-bd_a/b_plait_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 593, "End": 682 } ], "response#1": "MERIKHAATNSSLDRDGMAAVVDMYATWCGYLRRCAMDPNASDESVDLADSGLVAALEAVQVWGERRFGSAFQGDPNYRLERIMIYHLTEKHGAIDEAREHWDKLAQKELLAHDYSFWLSYYMWEMNLLQSQKGTGRSPTPAPAARLSRTPSRPASILQRALQVSQLNWPERVIEIYVKHCNDFESSDVLQNALDEVHNLQRVIAQRRKDATAAQTAQAEAHARAYESQALEASAAAAEAQALGKQQTGDPQDDLNAGVKRKWEAIASGETPESATKKPKNEDIGVNAAAPNSDQKSQENQPAKRDRENTSVFVSNLPSDVTITKVRQYFREYGHVNNIQLKHEENGKSTVALVEFRSVEDAQTALIRDGKYFGDHTISVKEAAGITLYVTNFPPSTDDESLHRLFGKSSNIFGIRWPSLKYNAHRRFCYVSFRDAESAAKATGLHGKMLEGKYKLSVQYSDPAAKKAREGATDEGREVHIKNIPQEFDEKEIEQLVSKYGTVKRVRLLHNMAGRSRGSAFVDLETKDEAERVVAELDKVKLGTQILKVELSVSAKFKPSARETSVASESATCNGGQEAPDEAKGEAGNEARGNLHLRSFALLGIPDTVNITRVRSLAEPHGHITKLKLYPEHGGAIIEYEDETTAGKAQLALDSTQLEGHTLRVDAVPQLFKEKSGVRIDRVDIAKRRPPKPTADTTSATMGKKAAPTTAPALLPAFVRRPVLGGKGVKHGLGFSAISATTSTKKDGQPTATNGAATSSTSSDTAPKKSNADFRALFLAGKSSTDSKEKVSEEKSKASGAPASVDKPDSKPDDTKMEIDVVVNGH", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more RRM_occluded, RRM_occluded, RRM_dom, RRM_dom, RRM_dom, RRM_dom, RRM_dom, RRM_dom, RRM_dom, RRM_dom_euk, RRM_dom_euk, RRM_dom_euk, RRM_dom, RRM_dom, RRM_dom, Prp24_RRM1, RRM_dom, Prp24_RRM2 that are essential for its biological function; 2. The protein should be classified within Nucleotide-bd_a/b_plait_sf, Nucleotide-bd_a/b_plait_sf, RBD_domain_sf, Nucleotide-bd_a/b_plait_sf, RBD_domain_sf, Nucleotide-bd_a/b_plait_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MERIKHAATNSSLDRDGMAAVVDMYATWCGYLRRCAMDPNASDESVDLADSGLVAALEAVQVWGERRFGSAFQGDPNYRLERIMIYHLTEKHGAIDEAREHWDKLAQKELLAHDYSFWLSYYMWEMNLLQSQKGTGRSPTPAPAARLSRTPSRPASILQRALQVSQLNWPERVIEIYVKHCNDFESSDVLQNALDEVHNLQRVIAQRRKDATAAQTAQAEAHARAYESQALEASAAAAEAQALGKQQTGDPQDDLNAGVKRKWEAIASGETPESATKKPKNEDIGVNAAAPNSDQKSQENQPAKRDRENTSVFVSNLPSDVTITKVRQYFREYGHVNNIQLKHEENGKSTVALVEFRSVEDAQTALIRDGKYFGDHTISVKEAAGITLYVTNFPPSTDDESLHRLFGKSSNIFGIRWPSLKYNAHRRFCYVSFRDAESAAKATGLHGKMLEGKYKLSVQYSDPAAKKAREGATDEGREVHIKNIPQEFDEKEIEQLVSKYGTVKRVRLLHNMAGRSRGSAFVDLETKDEAERVVAELDKVKLGTQILKVELSVSAKFKPSARETSVASESATCNGGQEAPDEAKGEAGNEARGNLHLRSFALLGIPDTVNITRVRSLAEPHGHITKLKLYPEHGGAIIEYEDETTAGKAQLALDSTQLEGHTLRVDAVPQLFKEKSGVRIDRVDIAKRRPPKPTADTTSATMGKKAAPTTAPALLPAFVRRPVLGGKGVKHGLGFSAISATTSTKKDGQPTATNGAATSSTSSDTAPKKSNADFRALFLAGKSSTDSKEKVSEEKSKASGAPASVDKPDSKPDDTKMEIDVVVNGH" }, { "InterPro": [ { "InterPro-ID": "IPR037796", "InterPro-Name": "TAF6", "InterPro-Type": "FAMILY", "Beg": 15, "End": 704 } ], "response#1": "MKTSGASNTDELNKSSHSKVSKKSTKSRSKSAKLELTGKNSLSASASSSIASAVSGGVAVGSLPATPTHLNMVTTPTTPTSSLGNYNLFDASFAVAGSGGHGLAGGIAGAEASGNSSRMGHQKSYAGFDPRSIKIFWEQHDQTDVELSQDVCARLAEDASYKVWELINNVKIYSRHSGGVVTYDLVNEVLKDADVPPMLGAMDSDWDRIDYDGSFYFHSDKIFELSAEFQKEVNLCTPDDADFQSICPVEDKHMDQLRQCVQSLVTAALFADSKSQTAAVCHAFQTPLMGSIYRVIVSKMVQLLAFKQQDHLSQRCWRLLRACNYNATANHNACRPEYFNLAEVLVSQLMAPYETIKAPHVDPDPGQTTSIKMEFEEELKVEPDQCHNPETQENPEVMGVEKQEQEPQMFPGESTMEHTIYKLQSEEEELNPQPEAEHLSSYFACPVGNGLVDELCETIGQLASQSGYLHAECLFLIKRRLARFFEGRHVSSERDFRYISRAVRGLIALGEYAFREFIPYIYKLRVEEIPDSLWPDLAPAAIFLGGHDDVYLYEWLEYGCGAALQPFLVHYARAYEKMVTRRYVKAKQPAYRIESVPGVRRLEWSTLAAAMCHGDDPSKALKPKPTLCEAFPDLQSPNLQLNCAGNIRFKFAGCRPVLLKPKVATVPHSEDSPSSAANGGGGGGASSDILIAKRKLFKPLTNVRKWSPISGYHYLRI", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to TAF6 that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MKTSGASNTDELNKSSHSKVSKKSTKSRSKSAKLELTGKNSLSASASSSIASAVSGGVAVGSLPATPTHLNMVTTPTTPTSSLGNYNLFDASFAVAGSGGHGLAGGIAGAEASGNSSRMGHQKSYAGFDPRSIKIFWEQHDQTDVELSQDVCARLAEDASYKVWELINNVKIYSRHSGGVVTYDLVNEVLKDADVPPMLGAMDSDWDRIDYDGSFYFHSDKIFELSAEFQKEVNLCTPDDADFQSICPVEDKHMDQLRQCVQSLVTAALFADSKSQTAAVCHAFQTPLMGSIYRVIVSKMVQLLAFKQQDHLSQRCWRLLRACNYNATANHNACRPEYFNLAEVLVSQLMAPYETIKAPHVDPDPGQTTSIKMEFEEELKVEPDQCHNPETQENPEVMGVEKQEQEPQMFPGESTMEHTIYKLQSEEEELNPQPEAEHLSSYFACPVGNGLVDELCETIGQLASQSGYLHAECLFLIKRRLARFFEGRHVSSERDFRYISRAVRGLIALGEYAFREFIPYIYKLRVEEIPDSLWPDLAPAAIFLGGHDDVYLYEWLEYGCGAALQPFLVHYARAYEKMVTRRYVKAKQPAYRIESVPGVRRLEWSTLAAAMCHGDDPSKALKPKPTLCEAFPDLQSPNLQLNCAGNIRFKFAGCRPVLLKPKVATVPHSEDSPSSAANGGGGGGASSDILIAKRKLFKPLTNVRKWSPISGYHYLRI" }, { "InterPro": [ { "InterPro-ID": "IPR045094", "InterPro-Name": "NMNAT_euk", "InterPro-Type": "FAMILY", "Beg": 46, "End": 282 }, { "InterPro-ID": "IPR051182", "InterPro-Name": "Euk_NMN_adenylyltrnsfrase", "InterPro-Type": "FAMILY", "Beg": 45, "End": 285 }, { "InterPro-ID": "IPR004821", "InterPro-Name": "Cyt_trans-like", "InterPro-Type": "DOMAIN", "Beg": 49, "End": 256 }, { "InterPro-ID": "IPR005248", "InterPro-Name": "NadD/NMNAT", "InterPro-Type": "FAMILY", "Beg": 49, "End": 281 }, { "InterPro-ID": "IPR014729", "InterPro-Name": "Rossmann-like_a/b/a_fold", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 45, "End": 291 } ], "response#1": "MIVKISWPKNNITSECFRRFGSFKRRSKSKKMSAFIEETKSLLPRIAFIACGCFSPPTPMHLRMFEIAKDHFEMQGTHRVVGGIISPTHDSYGKKGLASALDRCAMVKLATQSSNWIRLSDWEVHQNQWMRTQAVLQHHQNYINNHINSGGGGGDDGENTHLPGWLPRGLHDSRDPVHLKLLCGADLLESFAVPGLWAEADIEDIVANHGLVVITRAGSNPGKFIFDSDILTKYQSNITLITNWVPNEVSSTLIRRLLGRGQSVKYLLDDLVLEYIKRQRLFNFKSKYITDAVRPNHLLFNHAYTDNNKNANSYSIGDQLEQDMDESDTPSPQLQHTPTSRVFCCGEVPLRGSKVLRSGPGQAVQVITMQADEKEESQAKKQKISQVQL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Cyt_trans-like that are essential for its biological function; 2. The protein should belong to NMNAT_euk, Euk_NMN_adenylyltrnsfrase, NadD/NMNAT that shares evolutionary origin and functional similarity; 3. The protein should be classified within Rossmann-like_a/b/a_fold sharing conserved structural features. The designed protein sequence is ", "reference": "MIVKISWPKNNITSECFRRFGSFKRRSKSKKMSAFIEETKSLLPRIAFIACGCFSPPTPMHLRMFEIAKDHFEMQGTHRVVGGIISPTHDSYGKKGLASALDRCAMVKLATQSSNWIRLSDWEVHQNQWMRTQAVLQHHQNYINNHINSGGGGGDDGENTHLPGWLPRGLHDSRDPVHLKLLCGADLLESFAVPGLWAEADIEDIVANHGLVVITRAGSNPGKFIFDSDILTKYQSNITLITNWVPNEVSSTLIRRLLGRGQSVKYLLDDLVLEYIKRQRLFNFKSKYITDAVRPNHLLFNHAYTDNNKNANSYSIGDQLEQDMDESDTPSPQLQHTPTSRVFCCGEVPLRGSKVLRSGPGQAVQVITMQADEKEESQAKKQKISQVQL" }, { "InterPro": [ { "InterPro-ID": "IPR001876", "InterPro-Name": "Znf_RanBP2", "InterPro-Type": "DOMAIN", "Beg": 842, "End": 871 }, { "InterPro-ID": "IPR036443", "InterPro-Name": "Znf_RanBP2_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 843, "End": 870 }, { "InterPro-ID": "IPR001876", "InterPro-Name": "Znf_RanBP2", "InterPro-Type": "DOMAIN", "Beg": 846, "End": 865 }, { "InterPro-ID": "IPR001876", "InterPro-Name": "Znf_RanBP2", "InterPro-Type": "DOMAIN", "Beg": 844, "End": 868 }, { "InterPro-ID": "IPR001876", "InterPro-Name": "Znf_RanBP2", "InterPro-Type": "DOMAIN", "Beg": 787, "End": 811 }, { "InterPro-ID": "IPR001876", "InterPro-Name": "Znf_RanBP2", "InterPro-Type": "DOMAIN", "Beg": 656, "End": 680 }, { "InterPro-ID": "IPR001876", "InterPro-Name": "Znf_RanBP2", "InterPro-Type": "DOMAIN", "Beg": 719, "End": 743 }, { "InterPro-ID": "IPR036443", "InterPro-Name": "Znf_RanBP2_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 656, "End": 681 }, { "InterPro-ID": "IPR018892", "InterPro-Name": "Retro-transposon_transp_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 1373, "End": 1462 }, { "InterPro-ID": "IPR001876", "InterPro-Name": "Znf_RanBP2", "InterPro-Type": "DOMAIN", "Beg": 658, "End": 677 }, { "InterPro-ID": "IPR036443", "InterPro-Name": "Znf_RanBP2_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 719, "End": 745 }, { "InterPro-ID": "IPR013913", "InterPro-Name": "Nup153_N", "InterPro-Type": "DOMAIN", "Beg": 114, "End": 617 }, { "InterPro-ID": "IPR001876", "InterPro-Name": "Znf_RanBP2", "InterPro-Type": "DOMAIN", "Beg": 721, "End": 740 }, { "InterPro-ID": "IPR026054", "InterPro-Name": "Nucleoporin", "InterPro-Type": "FAMILY", "Beg": 1, "End": 829 }, { "InterPro-ID": "IPR001876", "InterPro-Name": "Znf_RanBP2", "InterPro-Type": "DOMAIN", "Beg": 785, "End": 814 }, { "InterPro-ID": "IPR001876", "InterPro-Name": "Znf_RanBP2", "InterPro-Type": "DOMAIN", "Beg": 789, "End": 808 }, { "InterPro-ID": "IPR001876", "InterPro-Name": "Znf_RanBP2", "InterPro-Type": "DOMAIN", "Beg": 653, "End": 683 }, { "InterPro-ID": "IPR001876", "InterPro-Name": "Znf_RanBP2", "InterPro-Type": "DOMAIN", "Beg": 786, "End": 814 }, { "InterPro-ID": "IPR001876", "InterPro-Name": "Znf_RanBP2", "InterPro-Type": "DOMAIN", "Beg": 719, "End": 746 }, { "InterPro-ID": "IPR001876", "InterPro-Name": "Znf_RanBP2", "InterPro-Type": "DOMAIN", "Beg": 653, "End": 682 }, { "InterPro-ID": "IPR001876", "InterPro-Name": "Znf_RanBP2", "InterPro-Type": "DOMAIN", "Beg": 717, "End": 746 } ], "response#1": "MASEAGGIGGGGGGGKIRTRRCHQGPVKPYQQGRPQHQGILSRVTESVKNIVPGWLQRYFNKSENACSCSPDADEVPPWPENREDEHAIYADENTNTDDGRITPDPAGSNTEEPSTTSTASNYPDVLTRPSLHRSHLNFSVLESPALHCQPSTSSAFPIGSSGFSLVKEIKDSTSQHDDDNISTTSGFSSRASEKDIAVSKNTSLPPLWSPEAERSHSLSQHTAISSKKPAFNLSAFGTLSTSLGNSSILKTSQLGDSPFYPGKTTYGGAAAAVRQNKVRSTPYQAPVRRQMKAKQLNAQSYGVTSSTARRILQSLEKMSSPLADAKRIPSAVSSPLNSPLDRSGIDNTVFQAKKEKVDSQYPPVQRLMTPKPVSIATNRTVYFKPSLTPSGDLRKTNQRIDKKNSTVDEKSISRQNREQESGFSYPNFSIPAANGLSSGVGGGGGKMRRERTHFVAPKPPENEEVEAPLLPQISLPISSSSLPTFSFSSPVTSASPSPVSSSQPLPNKVQMTSLGSTGSPVFTFSSPIVKSTQAAVLPPASIGFTFSVPLAKTEFSGSNSSSETVLSSSAQDITAVNSSSYKKRSAPCEDPFTPAKILREGSVLDILKTPGFASPKVDSPALQPTTTSSIVYTRPAISTFSSSGIEYGESLKAGSSWQCDTCLLQNKVTDNKCIACQAAKLPLKETAKQTGTGTPSKSDKPASTSGTGFGDKFKPAIGTWDCDTCLVQNKPEAVKCVACETPKPGTGVKRALTLTVASESPVTASSSTTVTTGTLGFGDKFKRPVGSWECPVCCVCNKAEDNRCVSCTSEKPGLVSASSSSPAPVSLSSGGCLGLDKFKKPEGSWDCEVCLVQNKADSAKCIACESAKPGTKSEFKGFGTSSSLNPAPSAFKFGIPSSSSGLSQTLTSTGNFKFGDQGGFKLGTSSDSGSTNTMNTNFKFSKPTGDFKFGVLSDSKPEEVKNDNKNDNFQFGSSSGLTNPASSAPFQFGVSTLGQQEKKEELPKSSPAGFSFGAGVNNPPNAAIDTTATSENKSGFNFGTLDTKSVSVTPFTYKTTEAKKEDAPATKGGFTFGKVGSSSLPSSSMFVLGRTEEKQQEPVTSTSLVFGKKADSEEPKCQPVFSFGNSEQTKDESSKPTFSFSVAKPSGKESEQLAKATFAFGNQTNTTTDQGAAKPVFSFLNSSSSSSSAPATSSSGGIFGSSTSSSNPPVAAFVFGQASNPVSSSAFGNAAESSTSQSLLFPQESEPATTSSTAPAASPFVFGTGASSNSVSSGFTFGATTTSSSSGSSFVFGTGHSAPSASPAFGANQTPTFGQSQGASQPNPPSFGSISSSTALFSAGSQPVPPPIFGTVSSSSQPPVFGQQPSQSAFGSGTANASSVFQFGSSTTNFNFTNNNPSGVFTFGASPSTPAASAQPSGSGVFSFSQSPASFTVGSNGKNMFSSSGTSVSGRKIKTAVRRKK", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Znf_RanBP2, Znf_RanBP2, Znf_RanBP2, Znf_RanBP2, Znf_RanBP2, Znf_RanBP2, Znf_RanBP2, Nup153_N, Znf_RanBP2, Znf_RanBP2, Znf_RanBP2, Znf_RanBP2, Znf_RanBP2, Znf_RanBP2, Znf_RanBP2, Znf_RanBP2 that are essential for its biological function; 2. The protein should belong to Nucleoporin that shares evolutionary origin and functional similarity; 3. The protein should be classified within Znf_RanBP2_sf, Znf_RanBP2_sf, Znf_RanBP2_sf sharing conserved structural features; 4. The protein should contain Retro-transposon_transp_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MASEAGGIGGGGGGGKIRTRRCHQGPVKPYQQGRPQHQGILSRVTESVKNIVPGWLQRYFNKSENACSCSPDADEVPPWPENREDEHAIYADENTNTDDGRITPDPAGSNTEEPSTTSTASNYPDVLTRPSLHRSHLNFSVLESPALHCQPSTSSAFPIGSSGFSLVKEIKDSTSQHDDDNISTTSGFSSRASEKDIAVSKNTSLPPLWSPEAERSHSLSQHTAISSKKPAFNLSAFGTLSTSLGNSSILKTSQLGDSPFYPGKTTYGGAAAAVRQNKVRSTPYQAPVRRQMKAKQLNAQSYGVTSSTARRILQSLEKMSSPLADAKRIPSAVSSPLNSPLDRSGIDNTVFQAKKEKVDSQYPPVQRLMTPKPVSIATNRTVYFKPSLTPSGDLRKTNQRIDKKNSTVDEKSISRQNREQESGFSYPNFSIPAANGLSSGVGGGGGKMRRERTHFVAPKPPENEEVEAPLLPQISLPISSSSLPTFSFSSPVTSASPSPVSSSQPLPNKVQMTSLGSTGSPVFTFSSPIVKSTQAAVLPPASIGFTFSVPLAKTEFSGSNSSSETVLSSSAQDITAVNSSSYKKRSAPCEDPFTPAKILREGSVLDILKTPGFASPKVDSPALQPTTTSSIVYTRPAISTFSSSGIEYGESLKAGSSWQCDTCLLQNKVTDNKCIACQAAKLPLKETAKQTGTGTPSKSDKPASTSGTGFGDKFKPAIGTWDCDTCLVQNKPEAVKCVACETPKPGTGVKRALTLTVASESPVTASSSTTVTTGTLGFGDKFKRPVGSWECPVCCVCNKAEDNRCVSCTSEKPGLVSASSSSPAPVSLSSGGCLGLDKFKKPEGSWDCEVCLVQNKADSAKCIACESAKPGTKSEFKGFGTSSSLNPAPSAFKFGIPSSSSGLSQTLTSTGNFKFGDQGGFKLGTSSDSGSTNTMNTNFKFSKPTGDFKFGVLSDSKPEEVKNDNKNDNFQFGSSSGLTNPASSAPFQFGVSTLGQQEKKEELPKSSPAGFSFGAGVNNPPNAAIDTTATSENKSGFNFGTLDTKSVSVTPFTYKTTEAKKEDAPATKGGFTFGKVGSSSLPSSSMFVLGRTEEKQQEPVTSTSLVFGKKADSEEPKCQPVFSFGNSEQTKDESSKPTFSFSVAKPSGKESEQLAKATFAFGNQTNTTTDQGAAKPVFSFLNSSSSSSSAPATSSSGGIFGSSTSSSNPPVAAFVFGQASNPVSSSAFGNAAESSTSQSLLFPQESEPATTSSTAPAASPFVFGTGASSNSVSSGFTFGATTTSSSSGSSFVFGTGHSAPSASPAFGANQTPTFGQSQGASQPNPPSFGSISSSTALFSAGSQPVPPPIFGTVSSSSQPPVFGQQPSQSAFGSGTANASSVFQFGSSTTNFNFTNNNPSGVFTFGASPSTPAASAQPSGSGVFSFSQSPASFTVGSNGKNMFSSSGTSVSGRKIKTAVRRKK" }, { "InterPro": [ { "InterPro-ID": "IPR017170", "InterPro-Name": "Lhr-like_ATP-dep_RNA_helic_prd", "InterPro-Type": "FAMILY", "Beg": 3, "End": 861 }, { "InterPro-ID": "IPR001650", "InterPro-Name": "Helicase_C-like", "InterPro-Type": "DOMAIN", "Beg": 273, "End": 379 }, { "InterPro-ID": "IPR045628", "InterPro-Name": "Lhr_WH_dom", "InterPro-Type": "DOMAIN", "Beg": 409, "End": 572 }, { "InterPro-ID": "IPR001650", "InterPro-Name": "Helicase_C-like", "InterPro-Type": "DOMAIN", "Beg": 275, "End": 424 }, { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 8, "End": 232 }, { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 45, "End": 391 }, { "InterPro-ID": "IPR011545", "InterPro-Name": "DEAD/DEAH_box_helicase_dom", "InterPro-Type": "DOMAIN", "Beg": 34, "End": 220 }, { "InterPro-ID": "IPR014001", "InterPro-Name": "Helicase_ATP-bd", "InterPro-Type": "DOMAIN", "Beg": 29, "End": 254 }, { "InterPro-ID": "IPR014001", "InterPro-Name": "Helicase_ATP-bd", "InterPro-Type": "DOMAIN", "Beg": 41, "End": 234 }, { "InterPro-ID": "IPR052511", "InterPro-Name": "ATP-dep_Helicase", "InterPro-Type": "FAMILY", "Beg": 9, "End": 861 }, { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 262, "End": 402 }, { "InterPro-ID": "IPR001650", "InterPro-Name": "Helicase_C-like", "InterPro-Type": "DOMAIN", "Beg": 301, "End": 383 }, { "InterPro-ID": "IPR013701", "InterPro-Name": "DEAD/DEAH_assoc", "InterPro-Type": "DOMAIN", "Beg": 639, "End": 827 } ], "response#1": "MIRFAQREYTDEEIYEILADPVREWFRGKFGTFTPPQRYAVIEIHKGENVLISSPTGSGKTLSAFLAAINELILLGKEGKLEDKIYVLYVSPLRALNNDIRRNLEEPLREIREVAHEMGYDLPEIRVAVRTSDTSSYEKQKMVKKPPHILITTPESLAIALNAPKFSERLKTVKYVIVDEVHALAENKRGTHLMLSLERLQNLAGDFVRIGLSATIHPLEEVAKFVFGFNDDGTPRSGLIVDVSFAKKTEIKVESVVGDLVYTDAATLSEALYKRLDELIEQHRTTLIFTNTRSGAERVAYHLKKKFPKYAELIEAHHSSLSRDVRLEVEEKLKKGELRCVVSSTSLELGIDIGSIDLVVLIGSPKSVNRALQRIGRAGHRLHEVSKGIILVLDRDDLVECTVLAYNARNRRLDRIKIPQNPLDVLVQHLLGMALEKVWDINEAYKLVRRAYPYHNLSFEDFMSVLRYLAGEYAGLEEKKVYAKIWLDEKEGKFGRRGKMTRAIYYMNTGTIPDEAKIEVYTLDRRFIGTVEEEFAERLMPGDIFVLAGRTYEFKKSRGNRIYVEPKEGAKPTIPAWFSEMLPLSFDLALDVQRFRKEVKELLNNPKAEQILMEKYRIDEKAAKAILGYFREQAKYSTIPDDGILLVEEVLEERRAKYFFHTLIGRRANEALSRAFAYLVSKKKRCNVGIAISDNGFMLILPREKRLSEEDIRTLFQLEDLRETLKKALDNTELLKRRFRHVANRGLLILRRYMGRKKSLSRQQLNAQTLLRLLKKNYPDFPLLKEVYREIMEDKMDIKNAELFLSWVKEGKIKIVFEQNELPSPFAFNLEIIGASDVVLMEDRRELIKQLHRKIMAMIGELE", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Helicase_C-like, Lhr_WH_dom, Helicase_C-like, DEAD/DEAH_box_helicase_dom, Helicase_ATP-bd, Helicase_ATP-bd, Helicase_C-like, DEAD/DEAH_assoc that are essential for its biological function; 2. The protein should belong to Lhr-like_ATP-dep_RNA_helic_prd, ATP-dep_Helicase that shares evolutionary origin and functional similarity; 3. The protein should be classified within P-loop_NTPase, P-loop_NTPase, P-loop_NTPase sharing conserved structural features. The designed protein sequence is ", "reference": "MIRFAQREYTDEEIYEILADPVREWFRGKFGTFTPPQRYAVIEIHKGENVLISSPTGSGKTLSAFLAAINELILLGKEGKLEDKIYVLYVSPLRALNNDIRRNLEEPLREIREVAHEMGYDLPEIRVAVRTSDTSSYEKQKMVKKPPHILITTPESLAIALNAPKFSERLKTVKYVIVDEVHALAENKRGTHLMLSLERLQNLAGDFVRIGLSATIHPLEEVAKFVFGFNDDGTPRSGLIVDVSFAKKTEIKVESVVGDLVYTDAATLSEALYKRLDELIEQHRTTLIFTNTRSGAERVAYHLKKKFPKYAELIEAHHSSLSRDVRLEVEEKLKKGELRCVVSSTSLELGIDIGSIDLVVLIGSPKSVNRALQRIGRAGHRLHEVSKGIILVLDRDDLVECTVLAYNARNRRLDRIKIPQNPLDVLVQHLLGMALEKVWDINEAYKLVRRAYPYHNLSFEDFMSVLRYLAGEYAGLEEKKVYAKIWLDEKEGKFGRRGKMTRAIYYMNTGTIPDEAKIEVYTLDRRFIGTVEEEFAERLMPGDIFVLAGRTYEFKKSRGNRIYVEPKEGAKPTIPAWFSEMLPLSFDLALDVQRFRKEVKELLNNPKAEQILMEKYRIDEKAAKAILGYFREQAKYSTIPDDGILLVEEVLEERRAKYFFHTLIGRRANEALSRAFAYLVSKKKRCNVGIAISDNGFMLILPREKRLSEEDIRTLFQLEDLRETLKKALDNTELLKRRFRHVANRGLLILRRYMGRKKSLSRQQLNAQTLLRLLKKNYPDFPLLKEVYREIMEDKMDIKNAELFLSWVKEGKIKIVFEQNELPSPFAFNLEIIGASDVVLMEDRRELIKQLHRKIMAMIGELE" }, { "InterPro": [ { "InterPro-ID": "IPR011009", "InterPro-Name": "Kinase-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 234, "End": 534 }, { "InterPro-ID": "IPR000719", "InterPro-Name": "Prot_kinase_dom", "InterPro-Type": "DOMAIN", "Beg": 234, "End": 526 }, { "InterPro-ID": "IPR000719", "InterPro-Name": "Prot_kinase_dom", "InterPro-Type": "DOMAIN", "Beg": 234, "End": 527 }, { "InterPro-ID": "IPR027916", "InterPro-Name": "Kinase-like_dom_Apicomplexa", "InterPro-Type": "DOMAIN", "Beg": 221, "End": 514 }, { "InterPro-ID": "IPR016815", "InterPro-Name": "Rhoptry_Rop2-like", "InterPro-Type": "FAMILY", "Beg": 1, "End": 549 } ], "response#1": "MATKLARLATWLVLVGCLLWRAGAVQLSPPNSRTNDLASGTPHVARGDTEAQSGTGDDSDFPQAVVEEVADMSGGRVPRVPASSTTTSASEGIFRRLVRRLRRGRGTADGAGVADETHQGPRPPLRKRLAQHFRRLRGFFGRLTPRWLSGLGRRAQRWWRGRQRPLLDPSFHGLEAGDSFMRDLLKREEELIGYCREEALKEPAAMVEAVTATVWPQNAETTVDSLLSQGERKLKLVEPLRVGDRSVVFLVRDVERLEDFALKVFTMGAENSRSELERLHEATFAAARLLGESPEEARDRRRLLLPSDAVAVQSQPPFAQLSPGQDDYAVANYLLLMPAASVDLELLFSTLDFVYVFRGDEGILALHILTAQLIRLAANLQSKGLVHGHFTPDNLFIMPDGRLMLGDVSALWKVGTRGPASSVPVTYAPREFLNASTATFTHALNAWQLGLSIYRVWCLFLPFGLVTPGIKGSWKRPSLRVPGTDSLAFGSCTPLPDFVKTLIGRFLNFDRRRRLLPLEAMETPEFLQLQNEISSSLSTGQPTAAPSVA", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Prot_kinase_dom, Prot_kinase_dom, Kinase-like_dom_Apicomplexa that are essential for its biological function; 2. The protein should belong to Rhoptry_Rop2-like that shares evolutionary origin and functional similarity; 3. The protein should be classified within Kinase-like_dom_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MATKLARLATWLVLVGCLLWRAGAVQLSPPNSRTNDLASGTPHVARGDTEAQSGTGDDSDFPQAVVEEVADMSGGRVPRVPASSTTTSASEGIFRRLVRRLRRGRGTADGAGVADETHQGPRPPLRKRLAQHFRRLRGFFGRLTPRWLSGLGRRAQRWWRGRQRPLLDPSFHGLEAGDSFMRDLLKREEELIGYCREEALKEPAAMVEAVTATVWPQNAETTVDSLLSQGERKLKLVEPLRVGDRSVVFLVRDVERLEDFALKVFTMGAENSRSELERLHEATFAAARLLGESPEEARDRRRLLLPSDAVAVQSQPPFAQLSPGQDDYAVANYLLLMPAASVDLELLFSTLDFVYVFRGDEGILALHILTAQLIRLAANLQSKGLVHGHFTPDNLFIMPDGRLMLGDVSALWKVGTRGPASSVPVTYAPREFLNASTATFTHALNAWQLGLSIYRVWCLFLPFGLVTPGIKGSWKRPSLRVPGTDSLAFGSCTPLPDFVKTLIGRFLNFDRRRRLLPLEAMETPEFLQLQNEISSSLSTGQPTAAPSVA" }, { "InterPro": [ { "InterPro-ID": "IPR001841", "InterPro-Name": "Znf_RING", "InterPro-Type": "DOMAIN", "Beg": 161, "End": 226 }, { "InterPro-ID": "IPR003649", "InterPro-Name": "Bbox_C", "InterPro-Type": "DOMAIN", "Beg": 368, "End": 494 }, { "InterPro-ID": "IPR013083", "InterPro-Name": "Znf_RING/FYVE/PHD", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 155, "End": 258 }, { "InterPro-ID": "IPR001841", "InterPro-Name": "Znf_RING", "InterPro-Type": "DOMAIN", "Beg": 161, "End": 227 }, { "InterPro-ID": "IPR011042", "InterPro-Name": "6-blade_b-propeller_TolB-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 924, "End": 1205 }, { "InterPro-ID": "IPR001258", "InterPro-Name": "NHL_repeat", "InterPro-Type": "REPEAT", "Beg": 937, "End": 980 }, { "InterPro-ID": "IPR000315", "InterPro-Name": "Znf_B-box", "InterPro-Type": "DOMAIN", "Beg": 318, "End": 361 }, { "InterPro-ID": "IPR000315", "InterPro-Name": "Znf_B-box", "InterPro-Type": "DOMAIN", "Beg": 257, "End": 304 }, { "InterPro-ID": "IPR001258", "InterPro-Name": "NHL_repeat", "InterPro-Type": "REPEAT", "Beg": 997, "End": 1027 }, { "InterPro-ID": "IPR001258", "InterPro-Name": "NHL_repeat", "InterPro-Type": "REPEAT", "Beg": 1086, "End": 1111 }, { "InterPro-ID": "IPR001258", "InterPro-Name": "NHL_repeat", "InterPro-Type": "REPEAT", "Beg": 950, "End": 977 }, { "InterPro-ID": "IPR000315", "InterPro-Name": "Znf_B-box", "InterPro-Type": "DOMAIN", "Beg": 318, "End": 357 }, { "InterPro-ID": "IPR047153", "InterPro-Name": "TRIM45/56/19-like", "InterPro-Type": "FAMILY", "Beg": 160, "End": 501 }, { "InterPro-ID": "IPR017907", "InterPro-Name": "Znf_RING_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 176, "End": 185 }, { "InterPro-ID": "IPR000315", "InterPro-Name": "Znf_B-box", "InterPro-Type": "DOMAIN", "Beg": 321, "End": 358 } ], "response#1": "MTTLEEPVQAADTVDPCPPGIPNLKTVLSDDASNSSVLEDIDVSNTSSSSSSSSSSSSSSGSCSGSGTDTDTGKGSSNVGSLDVTSSSSIGSETSISSTGSTAIAGPSTLLDDSNSSGLGLVVDVDSNGSSQELSSHGVTELDSLEDSCSGLMIKDGDKLCKLCSLRLVMPRILSCLHVFCEDCLQAVVSKDTMSASSPNSCSSSSFDGSEHQNRLSAVFIECPVCKQETPLGPKGIKALPCDYIVTNILDLSNLESEHIVCTSCKSKEEAISRCNDCANFLCNGCDNAHKYMRCFENHHVVRIEDLTKNVHDKLIIHKPVFCPQHVSENLKYYCFTCQVPTCNDCLLSDHKGSDHHYETATVAEQAVRADLEETLSDTLKKADYCNDAGSNLGSALTELQSQHDTVRQQIEDAYKCYKRMLESIKDQMLNELGRLHSDRELKIMDLMQSMENTMGKLQHAAQFGQRAVDKANSIEFLLLKPIISAQCLNLMEQTPKCDINYQLQFDSKPEMFEQFAREMFGKFQTDHIDSSPKKLGMTQQLQQQQQQQQQLQQQQHQHQHQVQQQQHHHQQQQQQKQQVQHQQQQQKLQLQQQQQHQHNSNNLIVGHRGSSSVQGRLTSAVFSPISLPSSLQSSFDGDTNSVMSNFSMMDSPPQPSSQQQLPSAQQQSQQQQQQQQQQQAVVLQQVQQQQKHQQHQVQQQQQQQVLHQPTSAQSMPQQLGQLVAPQGIVQQAGHVNLNAGPGPNISINGLGAGGPPPSFSMLEYNISRLASLTETMPDTLNDALAVGGGAAGPVPNVVAQVPGGSAVTGAAVVGASHAHQQQSQAVMPASAVTPTQPITLADILSGDQRALNNLQALAKLGLNNNDDGLLLNGSSTEIDFLSDFCMPPATSPSLQSLNPIVGGVEDMGLNNFHAVAAPGTTSVVTGRNKATPMQIRCKFGSLGTAKGQFNSPHGFCLGVDEEIIVADTNNHRIEVFDKMGALKFQFGVAGKEEGQLWYPRKVAVMHNNGKFVVCDRGNERSRMQIFSKCGHFMRKIAIRYIDIVAGLAVTAKGHIVAVDSVSPTVFVISEEGELVRWFDCSDYMREPSDIAIRDNDFYVCDFKGHCVAVFQDDGTFLYRIGNEKVTCFPNGIDISNAGDVLIGDSHGNRFHVACYSREGALQSEFECPHVKVSRCCGLKITSEGYVVTLAKNNHHVLVLNTLYVH", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Znf_RING, Bbox_C, Znf_RING, Znf_B-box, Znf_B-box, Znf_B-box, Znf_B-box that are essential for its biological function; 2. The protein should belong to TRIM45/56/19-like that shares evolutionary origin and functional similarity; 3. The protein should be classified within Znf_RING/FYVE/PHD, 6-blade_b-propeller_TolB-like sharing conserved structural features; 4. The protein should include one or more NHL_repeat, NHL_repeat, NHL_repeat, NHL_repeat that provide structural or functional support; 5. The protein should contain Znf_RING_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MTTLEEPVQAADTVDPCPPGIPNLKTVLSDDASNSSVLEDIDVSNTSSSSSSSSSSSSSSGSCSGSGTDTDTGKGSSNVGSLDVTSSSSIGSETSISSTGSTAIAGPSTLLDDSNSSGLGLVVDVDSNGSSQELSSHGVTELDSLEDSCSGLMIKDGDKLCKLCSLRLVMPRILSCLHVFCEDCLQAVVSKDTMSASSPNSCSSSSFDGSEHQNRLSAVFIECPVCKQETPLGPKGIKALPCDYIVTNILDLSNLESEHIVCTSCKSKEEAISRCNDCANFLCNGCDNAHKYMRCFENHHVVRIEDLTKNVHDKLIIHKPVFCPQHVSENLKYYCFTCQVPTCNDCLLSDHKGSDHHYETATVAEQAVRADLEETLSDTLKKADYCNDAGSNLGSALTELQSQHDTVRQQIEDAYKCYKRMLESIKDQMLNELGRLHSDRELKIMDLMQSMENTMGKLQHAAQFGQRAVDKANSIEFLLLKPIISAQCLNLMEQTPKCDINYQLQFDSKPEMFEQFAREMFGKFQTDHIDSSPKKLGMTQQLQQQQQQQQQLQQQQHQHQHQVQQQQHHHQQQQQQKQQVQHQQQQQKLQLQQQQQHQHNSNNLIVGHRGSSSVQGRLTSAVFSPISLPSSLQSSFDGDTNSVMSNFSMMDSPPQPSSQQQLPSAQQQSQQQQQQQQQQQAVVLQQVQQQQKHQQHQVQQQQQQQVLHQPTSAQSMPQQLGQLVAPQGIVQQAGHVNLNAGPGPNISINGLGAGGPPPSFSMLEYNISRLASLTETMPDTLNDALAVGGGAAGPVPNVVAQVPGGSAVTGAAVVGASHAHQQQSQAVMPASAVTPTQPITLADILSGDQRALNNLQALAKLGLNNNDDGLLLNGSSTEIDFLSDFCMPPATSPSLQSLNPIVGGVEDMGLNNFHAVAAPGTTSVVTGRNKATPMQIRCKFGSLGTAKGQFNSPHGFCLGVDEEIIVADTNNHRIEVFDKMGALKFQFGVAGKEEGQLWYPRKVAVMHNNGKFVVCDRGNERSRMQIFSKCGHFMRKIAIRYIDIVAGLAVTAKGHIVAVDSVSPTVFVISEEGELVRWFDCSDYMREPSDIAIRDNDFYVCDFKGHCVAVFQDDGTFLYRIGNEKVTCFPNGIDISNAGDVLIGDSHGNRFHVACYSREGALQSEFECPHVKVSRCCGLKITSEGYVVTLAKNNHHVLVLNTLYVH" }, { "InterPro": [ { "InterPro-ID": "IPR026584", "InterPro-Name": "Rad9", "InterPro-Type": "FAMILY", "Beg": 1, "End": 435 }, { "InterPro-ID": "IPR007268", "InterPro-Name": "Rad9/Ddc1", "InterPro-Type": "FAMILY", "Beg": 14, "End": 258 }, { "InterPro-ID": "IPR046938", "InterPro-Name": "DNA_clamp_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 7, "End": 122 }, { "InterPro-ID": "IPR007268", "InterPro-Name": "Rad9/Ddc1", "InterPro-Type": "FAMILY", "Beg": 1, "End": 400 } ], "response#1": "MKYTLEGSNARVIAKAVQSLSKVGKEMFIEIDQQSLQMRAINATQSAVGSISFKRSMFEVYDMPPHSDFYCKISMKGCLAVFRNMNEVEYCELNLLDNQTNLQVNLRCKLETTKEATISIIDDQNINTNINTDQMPNIIRGDHKLLTDISNNFNSSEEELTLEANSGSVVAKNYIEGARVNDKFMRTQLKLKPSEFEQYQVTKETVITFCIKEFRAFLLFAECLNASLTLEFDEAGMPFLLKIKKHGEIECLLIMSTLSPDDISFSEDYCQKDLTVQDEDVRAAAAKRKSSVSKPNVTNKRKGSSSEPAAVQPKRRVEETQLESSLDNPLFQFRDSEAPSVQHPRILAEVDTVVLIEDEAEQEALMLAAADAALEASMAPAPEPPNSTEVCFINTDDSQQPKPAKSSSDEDETIPQSPERPNKVLGVLLGLLQGCVSRLKTMLRLDEHLISGYELL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Rad9, Rad9/Ddc1, Rad9/Ddc1 that shares evolutionary origin and functional similarity; 2. The protein should be classified within DNA_clamp_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MKYTLEGSNARVIAKAVQSLSKVGKEMFIEIDQQSLQMRAINATQSAVGSISFKRSMFEVYDMPPHSDFYCKISMKGCLAVFRNMNEVEYCELNLLDNQTNLQVNLRCKLETTKEATISIIDDQNINTNINTDQMPNIIRGDHKLLTDISNNFNSSEEELTLEANSGSVVAKNYIEGARVNDKFMRTQLKLKPSEFEQYQVTKETVITFCIKEFRAFLLFAECLNASLTLEFDEAGMPFLLKIKKHGEIECLLIMSTLSPDDISFSEDYCQKDLTVQDEDVRAAAAKRKSSVSKPNVTNKRKGSSSEPAAVQPKRRVEETQLESSLDNPLFQFRDSEAPSVQHPRILAEVDTVVLIEDEAEQEALMLAAADAALEASMAPAPEPPNSTEVCFINTDDSQQPKPAKSSSDEDETIPQSPERPNKVLGVLLGLLQGCVSRLKTMLRLDEHLISGYELL" }, { "InterPro": [ { "InterPro-ID": "IPR011696", "InterPro-Name": "Huwentoxin-1", "InterPro-Type": "FAMILY", "Beg": 1, "End": 31 } ], "response#1": "DCLGWFSGCDPNNNKCCEGYVCHWKYPWCRYDL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Huwentoxin-1 that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "DCLGWFSGCDPNNNKCCEGYVCHWKYPWCRYDL" }, { "InterPro": [ { "InterPro-ID": "IPR000719", "InterPro-Name": "Prot_kinase_dom", "InterPro-Type": "DOMAIN", "Beg": 252, "End": 531 }, { "InterPro-ID": "IPR011009", "InterPro-Name": "Kinase-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 255, "End": 535 }, { "InterPro-ID": "IPR017441", "InterPro-Name": "Protein_kinase_ATP_BS", "InterPro-Type": "BINDING_SITE", "Beg": 258, "End": 281 }, { "InterPro-ID": "IPR027916", "InterPro-Name": "Kinase-like_dom_Apicomplexa", "InterPro-Type": "DOMAIN", "Beg": 248, "End": 519 }, { "InterPro-ID": "IPR008271", "InterPro-Name": "Ser/Thr_kinase_AS", "InterPro-Type": "ACTIVE_SITE", "Beg": 405, "End": 417 } ], "response#1": "MFSVQRPPLTRTVVRMGLATLLPKTACLAGLNVALVFLLFQVQDGTGITLGPSKLDSKPTSLDSQQHVADKRWLATVGHYKHLAGATESTRDVSLLEERAQHRVNAQETNQRRTIFQRLLNLLRRRERDGEVSGSAADSSSRPRLSVRQRLAQLWRRAKSLFKRGIRRYFPQGRNRQRSLRAQRRRSELVFEKADSGCVIGKRILAHMQEQIGQPQALENSERLDRILTVAAWPPDVPKRFVSVTTGETRTLVRGAPLGSGGFATVYEATDVETNEELAVKVFMSEKEPTDETMLDLQRESSCYRNFSLAKTAKDAQESCRFMVPSDVVMLEGQPASTEVVIGLTTRWVPNYFLLMMRAEADMSKVISWVFGDASVNKSEFGLVVRMYLSSQAIKLVANVQAQGIVHTDIKPANFLLLKDGRLFLGDFGTYRINNSVGRAIGTPGYEPPERPFQATGITYTFPTDAWQLGITLYCIWCKERPTPADGIWDYLHFADCPSTPELVQDLIRSLLNRDPQKRMLPLQALETAAFKEMDSVVKGAAQNFEQQEHLHTE", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Prot_kinase_dom, Kinase-like_dom_Apicomplexa that are essential for its biological function; 2. The protein should be classified within Kinase-like_dom_sf sharing conserved structural features; 3. The protein must have Ser/Thr_kinase_AS that is conserved among related catalytic enzymes; 4. The protein should include a Protein_kinase_ATP_BS that enables ligand binding under diverse conditions. The designed protein sequence is ", "reference": "MFSVQRPPLTRTVVRMGLATLLPKTACLAGLNVALVFLLFQVQDGTGITLGPSKLDSKPTSLDSQQHVADKRWLATVGHYKHLAGATESTRDVSLLEERAQHRVNAQETNQRRTIFQRLLNLLRRRERDGEVSGSAADSSSRPRLSVRQRLAQLWRRAKSLFKRGIRRYFPQGRNRQRSLRAQRRRSELVFEKADSGCVIGKRILAHMQEQIGQPQALENSERLDRILTVAAWPPDVPKRFVSVTTGETRTLVRGAPLGSGGFATVYEATDVETNEELAVKVFMSEKEPTDETMLDLQRESSCYRNFSLAKTAKDAQESCRFMVPSDVVMLEGQPASTEVVIGLTTRWVPNYFLLMMRAEADMSKVISWVFGDASVNKSEFGLVVRMYLSSQAIKLVANVQAQGIVHTDIKPANFLLLKDGRLFLGDFGTYRINNSVGRAIGTPGYEPPERPFQATGITYTFPTDAWQLGITLYCIWCKERPTPADGIWDYLHFADCPSTPELVQDLIRSLLNRDPQKRMLPLQALETAAFKEMDSVVKGAAQNFEQQEHLHTE" }, { "InterPro": [ { "InterPro-ID": "IPR008271", "InterPro-Name": "Ser/Thr_kinase_AS", "InterPro-Type": "ACTIVE_SITE", "Beg": 432, "End": 444 }, { "InterPro-ID": "IPR000719", "InterPro-Name": "Prot_kinase_dom", "InterPro-Type": "DOMAIN", "Beg": 283, "End": 579 }, { "InterPro-ID": "IPR000719", "InterPro-Name": "Prot_kinase_dom", "InterPro-Type": "DOMAIN", "Beg": 283, "End": 578 }, { "InterPro-ID": "IPR017441", "InterPro-Name": "Protein_kinase_ATP_BS", "InterPro-Type": "BINDING_SITE", "Beg": 289, "End": 312 }, { "InterPro-ID": "IPR027916", "InterPro-Name": "Kinase-like_dom_Apicomplexa", "InterPro-Type": "DOMAIN", "Beg": 280, "End": 561 }, { "InterPro-ID": "IPR011009", "InterPro-Name": "Kinase-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 277, "End": 581 }, { "InterPro-ID": "IPR050205", "InterPro-Name": "CDPK_Ser/Thr_kinases", "InterPro-Type": "FAMILY", "Beg": 285, "End": 574 } ], "response#1": "MELVLCFVIITISGVIRESSALLLRSPTSNDVFGELVASAERAQPLATRLTKRISRLNFNDREDDFWEDHGDASWNNSYTLVNGRTTLGSENRRRPASHSLIERPYYRDGRLSPVLGVQERRGRSVHSYHEEPVSFFDQRAFDEYTFRRRSQLHRQRARAGLRSRIKQNVRRLWTSARGAVRGWGRRVRRKIGDLFVGHLMPQLRRLRFWDQGLPPVVPPLIGNEPGQASVALVAERMEARLREKTLTEKNPTEAQQAVGTYLINSAENTWFISIPGGRYILLKKRGFLGGGGFGLVYHVEHPTTGQPFALKIFVQRVMNNEVGDKISDLIEDEFGVMKYFPPEWTPARMYSELRFMVPLLKLRVLGKPEFQDARNHLRIFSVCALFPKAQGDLEEAAALLADMDRTNAYNMRMSSTIQMVKLLARFHAFGLVHGDVKLQNFLVDKSGLLLLSDFTQILRTNERRYPPVVTVLYMSPEIATCLITRLRNAIPYTAEIDSWMLGISLYRLWCGDFPFGITLDATALQVAGIVIRSSASSLDFASCHDIPEQFREMIVGFLRKTPGVRLSPQQALEQFSLLNWKGPSPASDTASESEPVSTEEAALLQKE", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Prot_kinase_dom, Prot_kinase_dom, Kinase-like_dom_Apicomplexa that are essential for its biological function; 2. The protein should belong to CDPK_Ser/Thr_kinases that shares evolutionary origin and functional similarity; 3. The protein should be classified within Kinase-like_dom_sf sharing conserved structural features; 4. The protein must have Ser/Thr_kinase_AS that is conserved among related catalytic enzymes; 5. The protein should include a Protein_kinase_ATP_BS that enables ligand binding under diverse conditions. The designed protein sequence is ", "reference": "MELVLCFVIITISGVIRESSALLLRSPTSNDVFGELVASAERAQPLATRLTKRISRLNFNDREDDFWEDHGDASWNNSYTLVNGRTTLGSENRRRPASHSLIERPYYRDGRLSPVLGVQERRGRSVHSYHEEPVSFFDQRAFDEYTFRRRSQLHRQRARAGLRSRIKQNVRRLWTSARGAVRGWGRRVRRKIGDLFVGHLMPQLRRLRFWDQGLPPVVPPLIGNEPGQASVALVAERMEARLREKTLTEKNPTEAQQAVGTYLINSAENTWFISIPGGRYILLKKRGFLGGGGFGLVYHVEHPTTGQPFALKIFVQRVMNNEVGDKISDLIEDEFGVMKYFPPEWTPARMYSELRFMVPLLKLRVLGKPEFQDARNHLRIFSVCALFPKAQGDLEEAAALLADMDRTNAYNMRMSSTIQMVKLLARFHAFGLVHGDVKLQNFLVDKSGLLLLSDFTQILRTNERRYPPVVTVLYMSPEIATCLITRLRNAIPYTAEIDSWMLGISLYRLWCGDFPFGITLDATALQVAGIVIRSSASSLDFASCHDIPEQFREMIVGFLRKTPGVRLSPQQALEQFSLLNWKGPSPASDTASESEPVSTEEAALLQKE" }, { "InterPro": [ { "InterPro-ID": "IPR002403", "InterPro-Name": "Cyt_P450_E_grp-IV", "InterPro-Type": "FAMILY", "Beg": 363, "End": 377 }, { "InterPro-ID": "IPR002403", "InterPro-Name": "Cyt_P450_E_grp-IV", "InterPro-Type": "FAMILY", "Beg": 326, "End": 342 }, { "InterPro-ID": "IPR002403", "InterPro-Name": "Cyt_P450_E_grp-IV", "InterPro-Type": "FAMILY", "Beg": 425, "End": 443 }, { "InterPro-ID": "IPR002403", "InterPro-Name": "Cyt_P450_E_grp-IV", "InterPro-Type": "FAMILY", "Beg": 379, "End": 397 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 294, "End": 402 }, { "InterPro-ID": "IPR036396", "InterPro-Name": "Cyt_P450_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 9, "End": 450 }, { "InterPro-ID": "IPR036396", "InterPro-Name": "Cyt_P450_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 12, "End": 447 } ], "response#1": "MSTSNGSTENIQKPLRKIPDITGTPILTAIKDRLDFFYNQGQYEYFQSRVKKNNSTILRMNMIPGPFASNPKIVALCDAASFPTLFDPSKVSKVNSLTGNYMPALSFTGGYRVCAYLDPSEPTHTKIKQVFFNAQAAKKDTFIPTFVSTFNSMFDKMDAEVESKKKAEFTKFNEAAVFEFVGLALVGPKPAREVFDSAKKSVFFQFHPFITAGLPALVEELAFHMFPFPSFVAKSSYKILYEYFSTGGSWILDNAEEIGLSREEAIHHLIFTWAINAYLGIRTCLMRLFKWIVASGPDLQEKLAREVRSVVRSEEGKITFAGIEKMELVKSVAYESFRFDPPVQVQYGTAKSDLIIESHDGKYQVKKGEMLCGFQPMATRDPKVFDRADEFVPDRFMGDGKKLVKHVLWANGYGTDAPKADDKICAGKDLGVLVGRLLIAVMFLRYDKIGGVVGKTMEEVDVIVNELTKVAV", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Cyt_P450_E_grp-IV, Cyt_P450_E_grp-IV, Cyt_P450_E_grp-IV, Cyt_P450_E_grp-IV, Cyt_P450 that shares evolutionary origin and functional similarity; 2. The protein should be classified within Cyt_P450_sf, Cyt_P450_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MSTSNGSTENIQKPLRKIPDITGTPILTAIKDRLDFFYNQGQYEYFQSRVKKNNSTILRMNMIPGPFASNPKIVALCDAASFPTLFDPSKVSKVNSLTGNYMPALSFTGGYRVCAYLDPSEPTHTKIKQVFFNAQAAKKDTFIPTFVSTFNSMFDKMDAEVESKKKAEFTKFNEAAVFEFVGLALVGPKPAREVFDSAKKSVFFQFHPFITAGLPALVEELAFHMFPFPSFVAKSSYKILYEYFSTGGSWILDNAEEIGLSREEAIHHLIFTWAINAYLGIRTCLMRLFKWIVASGPDLQEKLAREVRSVVRSEEGKITFAGIEKMELVKSVAYESFRFDPPVQVQYGTAKSDLIIESHDGKYQVKKGEMLCGFQPMATRDPKVFDRADEFVPDRFMGDGKKLVKHVLWANGYGTDAPKADDKICAGKDLGVLVGRLLIAVMFLRYDKIGGVVGKTMEEVDVIVNELTKVAV" }, { "InterPro": [ { "InterPro-ID": "IPR000757", "InterPro-Name": "GH16", "InterPro-Type": "DOMAIN", "Beg": 46, "End": 228 }, { "InterPro-ID": "IPR050546", "InterPro-Name": "Glycosyl_Hydrlase_16", "InterPro-Type": "FAMILY", "Beg": 8, "End": 243 }, { "InterPro-ID": "IPR017168", "InterPro-Name": "Glyco_hydro_16_CRH1_prd", "InterPro-Type": "FAMILY", "Beg": 1, "End": 447 }, { "InterPro-ID": "IPR000757", "InterPro-Name": "GH16", "InterPro-Type": "DOMAIN", "Beg": 64, "End": 221 }, { "InterPro-ID": "IPR013320", "InterPro-Name": "ConA-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 24, "End": 244 } ], "response#1": "MRLSLVGVAIGLLSSSAIVTAQTYTDCNPLQKTCPPDPALGRSVTYDFTKGSSPDFKPVGSPTYDSNNGAAFSVAKQGDAPLIQSNWYMMFGHVEFVIKTAPGKGIVSSAVLQSDDLDEIDWEWLGANNLYVQTNYFGKGDTGSYNRGAAHDNAGNQDGFHTYTIDWTSTQIVWQIDGKTVRVLTAESAGDHFPQSPMMVKVGVWAGGDPNNAPGTIQWAGGETDYSAGPYTMYLKSLVATDYSTGKSYTYSDKSGSWRSITSDGGQINGNSDAESISTVESAPPVTATIDSAPIPFSGTHRETSSFVTPSIWPWVPKPTTLSSSVAKDTTLPSGWTFSGSRQVQPPSAASSTPPCTSSSLVSSLASPSHSGLKTSSISSVPNSSSATKSTGHLASTATYQISTYDSTLPSFSASIAHVAPTVAAANDLLEAPLGMGVFCALLGGLIAIF", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more GH16, GH16 that are essential for its biological function; 2. The protein should belong to Glycosyl_Hydrlase_16, Glyco_hydro_16_CRH1_prd that shares evolutionary origin and functional similarity; 3. The protein should be classified within ConA-like_dom_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MRLSLVGVAIGLLSSSAIVTAQTYTDCNPLQKTCPPDPALGRSVTYDFTKGSSPDFKPVGSPTYDSNNGAAFSVAKQGDAPLIQSNWYMMFGHVEFVIKTAPGKGIVSSAVLQSDDLDEIDWEWLGANNLYVQTNYFGKGDTGSYNRGAAHDNAGNQDGFHTYTIDWTSTQIVWQIDGKTVRVLTAESAGDHFPQSPMMVKVGVWAGGDPNNAPGTIQWAGGETDYSAGPYTMYLKSLVATDYSTGKSYTYSDKSGSWRSITSDGGQINGNSDAESISTVESAPPVTATIDSAPIPFSGTHRETSSFVTPSIWPWVPKPTTLSSSVAKDTTLPSGWTFSGSRQVQPPSAASSTPPCTSSSLVSSLASPSHSGLKTSSISSVPNSSSATKSTGHLASTATYQISTYDSTLPSFSASIAHVAPTVAAANDLLEAPLGMGVFCALLGGLIAIF" }, { "InterPro": [ { "InterPro-ID": "IPR038055", "InterPro-Name": "Glycoprot_E_dimer_dom", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1085, "End": 1165 }, { "InterPro-ID": "IPR038055", "InterPro-Name": "Glycoprot_E_dimer_dom", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 987, "End": 1054 }, { "InterPro-ID": "IPR042306", "InterPro-Name": "Alphavir_E2_C", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 635, "End": 707 }, { "InterPro-ID": "IPR000930", "InterPro-Name": "Peptidase_S3", "InterPro-Type": "DOMAIN", "Beg": 133, "End": 281 }, { "InterPro-ID": "IPR000930", "InterPro-Name": "Peptidase_S3", "InterPro-Type": "DOMAIN", "Beg": 133, "End": 271 }, { "InterPro-ID": "IPR000930", "InterPro-Name": "Peptidase_S3", "InterPro-Type": "DOMAIN", "Beg": 145, "End": 169 }, { "InterPro-ID": "IPR000930", "InterPro-Name": "Peptidase_S3", "InterPro-Type": "DOMAIN", "Beg": 170, "End": 194 }, { "InterPro-ID": "IPR000930", "InterPro-Name": "Peptidase_S3", "InterPro-Type": "DOMAIN", "Beg": 244, "End": 270 }, { "InterPro-ID": "IPR000930", "InterPro-Name": "Peptidase_S3", "InterPro-Type": "DOMAIN", "Beg": 219, "End": 243 }, { "InterPro-ID": "IPR000930", "InterPro-Name": "Peptidase_S3", "InterPro-Type": "DOMAIN", "Beg": 124, "End": 137 }, { "InterPro-ID": "IPR000936", "InterPro-Name": "Alpha_E2_glycop", "InterPro-Type": "FAMILY", "Beg": 375, "End": 784 }, { "InterPro-ID": "IPR036253", "InterPro-Name": "Glycoprot_cen/dimer_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 859, "End": 1165 }, { "InterPro-ID": "IPR043504", "InterPro-Name": "Peptidase_S1_PA_chymotrypsin", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 126, "End": 196 }, { "InterPro-ID": "IPR038055", "InterPro-Name": "Glycoprot_E_dimer_dom", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 859, "End": 952 }, { "InterPro-ID": "IPR009003", "InterPro-Name": "Peptidase_S1_PA", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 127, "End": 281 }, { "InterPro-ID": "IPR043504", "InterPro-Name": "Peptidase_S1_PA_chymotrypsin", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 199, "End": 281 }, { "InterPro-ID": "IPR042305", "InterPro-Name": "Alphavir_E2_B", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 540, "End": 597 }, { "InterPro-ID": "IPR042304", "InterPro-Name": "Alphavir_E2_A", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 370, "End": 634 }, { "InterPro-ID": "IPR002533", "InterPro-Name": "Alpha_E3_glycop", "InterPro-Type": "DOMAIN", "Beg": 296, "End": 352 }, { "InterPro-ID": "IPR002548", "InterPro-Name": "Alpha_E1_glycop", "InterPro-Type": "DOMAIN", "Beg": 794, "End": 1309 }, { "InterPro-ID": "IPR014756", "InterPro-Name": "Ig_E-set", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1167, "End": 1264 }, { "InterPro-ID": "IPR000336", "InterPro-Name": "Flavivir/Alphavir_Ig-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1166, "End": 1266 } ], "response#1": "MFPMQFTNSAYRQMEPMFAPGPRGQVQPYRPRTKRRQEPQVGNAAIAALANQMSALQLQVAGLAGQARVDRRGPRRVQKSKQKKKNPSNGEKPKEKKKKQKQQEKKGSGGVIKKPRNRPGKEVRISVKRARQSTFPVYHDGAISGYAVLIGSRVFKPAHVKGKIDHPELADIKFQVAEDMDLEAAAYPKSMRDQAAEPATMMDGVYNWEYGTIRVEDNVVIDASGRGKPGDSGRAITDNSGKVVGIVLGGGPDGRRTRLSVIGFDKKMKAREIAYSEAIPWTRAPALLLLPMVIACTYNSNTFDCSKPSCQDCCITAEPKKAMAMLKDNLNDPNYWDLLIAVTTCNSARKKRAVSTSPAAVYDTQILAAHAAASPYRAYCPDCDGTACISPIAIDEVVSSGSDHVLRIRVGSQSGVTAKGGAAGETSLRYLGRDGKVHAADNTRLVVRTTAKCDVLQATGHYILASCPEGQSITVAATLDGTRHQCTTVFEHQVTEKFTRERSKGHHLSDLTKKCTRFSTTPKKSAPYLVDVYDALPISVEISTVVTCNDNQCTVKVPPGTTVKFDKKCKSAAQATVTFTSDSQTFTCEEPVLTAASITQGKPHLRSSMLPSGGKEVKARIPFPFPPETATCRVSVAPLPSITYEESDVLLAGTAKYPVLLTTRNLGFHSNATSEWIQGKYLRRIPVTPQGIELTWGNNAPLHFWSSVRYASGDADAYPWELLVHHTKHHPEYAWAFVGVACGLLVIAVCMFACACNRVRYSLVANTFNPNPPPLTALTAALCCIPGARADQPYLDIIAYLWTNSKVAFGLQCAAPVACVLIVTYALRHCRLCCKSFLGVRGWSALLVILAYVQSCKSYEHTVVVPMDPRAPSYEAVINRNGYDPLKLTIAVNFTVISPTTALEYWTCASVPIVEPPHVGCCTSVSCPSDLSTLHAFTGKAVSDVHCDVHTNVYPLLWGAAHCFCSTENTQVSAVAATVSEFCAQDSERAEAFSVHSSSVTAEVLVTLGEVVTAVHVYVDGVTSARGTDLKIVAGPITTDYSPFDRKVVRIGEEVYNYDWPPYGAGRPGTFGDIQARSTNYVKPNDLYGDIGIEVLQPTNDHVHVAYTYTTSGLLRWLQDAPKPLSVTAPHGCKISANPLLALDCGVGAVPMSINIPDAKFTRKLKDPKPSALKCVVDSCEYGVDYGGAATITYEGHEAGKCGIHSLTPGVPLRTSVVEVVAGANTVKTTFSSPTPEVTLEVEICSAMVTCASECTPPKEHVVATRPRHGSDTGGYISGPAMRWAGGIVGTLAVLFLILAVTYCVVKKCRSKRIRIVKS", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Peptidase_S3, Peptidase_S3, Peptidase_S3, Peptidase_S3, Peptidase_S3, Peptidase_S3, Peptidase_S3, Alpha_E3_glycop, Alpha_E1_glycop that are essential for its biological function; 2. The protein should belong to Alpha_E2_glycop that shares evolutionary origin and functional similarity; 3. The protein should be classified within Glycoprot_E_dimer_dom, Glycoprot_E_dimer_dom, Alphavir_E2_C, Glycoprot_cen/dimer_sf, Peptidase_S1_PA_chymotrypsin, Glycoprot_E_dimer_dom, Peptidase_S1_PA, Peptidase_S1_PA_chymotrypsin, Alphavir_E2_B, Alphavir_E2_A, Ig_E-set, Flavivir/Alphavir_Ig-like_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MFPMQFTNSAYRQMEPMFAPGPRGQVQPYRPRTKRRQEPQVGNAAIAALANQMSALQLQVAGLAGQARVDRRGPRRVQKSKQKKKNPSNGEKPKEKKKKQKQQEKKGSGGVIKKPRNRPGKEVRISVKRARQSTFPVYHDGAISGYAVLIGSRVFKPAHVKGKIDHPELADIKFQVAEDMDLEAAAYPKSMRDQAAEPATMMDGVYNWEYGTIRVEDNVVIDASGRGKPGDSGRAITDNSGKVVGIVLGGGPDGRRTRLSVIGFDKKMKAREIAYSEAIPWTRAPALLLLPMVIACTYNSNTFDCSKPSCQDCCITAEPKKAMAMLKDNLNDPNYWDLLIAVTTCNSARKKRAVSTSPAAVYDTQILAAHAAASPYRAYCPDCDGTACISPIAIDEVVSSGSDHVLRIRVGSQSGVTAKGGAAGETSLRYLGRDGKVHAADNTRLVVRTTAKCDVLQATGHYILASCPEGQSITVAATLDGTRHQCTTVFEHQVTEKFTRERSKGHHLSDLTKKCTRFSTTPKKSAPYLVDVYDALPISVEISTVVTCNDNQCTVKVPPGTTVKFDKKCKSAAQATVTFTSDSQTFTCEEPVLTAASITQGKPHLRSSMLPSGGKEVKARIPFPFPPETATCRVSVAPLPSITYEESDVLLAGTAKYPVLLTTRNLGFHSNATSEWIQGKYLRRIPVTPQGIELTWGNNAPLHFWSSVRYASGDADAYPWELLVHHTKHHPEYAWAFVGVACGLLVIAVCMFACACNRVRYSLVANTFNPNPPPLTALTAALCCIPGARADQPYLDIIAYLWTNSKVAFGLQCAAPVACVLIVTYALRHCRLCCKSFLGVRGWSALLVILAYVQSCKSYEHTVVVPMDPRAPSYEAVINRNGYDPLKLTIAVNFTVISPTTALEYWTCASVPIVEPPHVGCCTSVSCPSDLSTLHAFTGKAVSDVHCDVHTNVYPLLWGAAHCFCSTENTQVSAVAATVSEFCAQDSERAEAFSVHSSSVTAEVLVTLGEVVTAVHVYVDGVTSARGTDLKIVAGPITTDYSPFDRKVVRIGEEVYNYDWPPYGAGRPGTFGDIQARSTNYVKPNDLYGDIGIEVLQPTNDHVHVAYTYTTSGLLRWLQDAPKPLSVTAPHGCKISANPLLALDCGVGAVPMSINIPDAKFTRKLKDPKPSALKCVVDSCEYGVDYGGAATITYEGHEAGKCGIHSLTPGVPLRTSVVEVVAGANTVKTTFSSPTPEVTLEVEICSAMVTCASECTPPKEHVVATRPRHGSDTGGYISGPAMRWAGGIVGTLAVLFLILAVTYCVVKKCRSKRIRIVKS" }, { "InterPro": [ { "InterPro-ID": "IPR000203", "InterPro-Name": "GPS", "InterPro-Type": "CONSERVED_SITE", "Beg": 312, "End": 354 }, { "InterPro-ID": "IPR000203", "InterPro-Name": "GPS", "InterPro-Type": "CONSERVED_SITE", "Beg": 309, "End": 360 }, { "InterPro-ID": "IPR017981", "InterPro-Name": "GPCR_2-like_7TM", "InterPro-Type": "DOMAIN", "Beg": 369, "End": 619 }, { "InterPro-ID": "IPR000832", "InterPro-Name": "GPCR_2_secretin-like", "InterPro-Type": "FAMILY", "Beg": 368, "End": 610 }, { "InterPro-ID": "IPR046338", "InterPro-Name": "GAIN_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 196, "End": 348 }, { "InterPro-ID": "IPR000832", "InterPro-Name": "GPCR_2_secretin-like", "InterPro-Type": "FAMILY", "Beg": 437, "End": 460 }, { "InterPro-ID": "IPR000832", "InterPro-Name": "GPCR_2_secretin-like", "InterPro-Type": "FAMILY", "Beg": 474, "End": 499 }, { "InterPro-ID": "IPR000832", "InterPro-Name": "GPCR_2_secretin-like", "InterPro-Type": "FAMILY", "Beg": 371, "End": 395 }, { "InterPro-ID": "IPR000832", "InterPro-Name": "GPCR_2_secretin-like", "InterPro-Type": "FAMILY", "Beg": 597, "End": 618 }, { "InterPro-ID": "IPR000203", "InterPro-Name": "GPS", "InterPro-Type": "CONSERVED_SITE", "Beg": 310, "End": 360 } ], "response#1": "MKQNPAKTARMWIIICLLFVLGQATDNDRDFKMCGKWLHGIAPQNLEYDLKTGCERIEISANESTLSIQGRITAKCTQSSSIQLDSNPHQNQSHFCVFWEPLLDLLIVEVNGKNHTLCKPNGLQGTCCTDLSQGVQDNAHMYGIVNGSVKGDIITGDLKGNYIFDGAHINCKEKFCDEARLKPRGANMIEEVVMRFNAKGRVDLPCAQGTVIEMDEEFTGHNFTVPAPRFVDANTIPSVYIPSSLRSVSRRKSKVVCTYYKNKTLFERGPSKSALLDDIVGLSVENETIRNLIEPVKIRFHHRPFAPDSSGRCVSWDTKQDNEVNWKDDGCDTVKINEEQTECHCNHLTYFAILVQVEQKSTVRHLKALTFITAVGCAVSLVSCLVLFYWLCKRRRGKKNQISLVHRGLVVAIFLLCLFFILTGILANVANETVCQLTGSLLHYGLLSTLCWMAMEVFHTFLLVRKVFNSPLPIWIFYLMGFGFPFLLVSILLSVGDIYGERKIKPSDDVNNPYRMCWMTEGDKSQLAHYIINIGLLAVVVSSGLVMLFLVVREIRNRPDWKKIHVAFLSIWGLTCLYGTTWALGFLDFGPFSEVTLFLFCIINSLQGFFLMLRYYALERMKKKDVSSSDGSSSGSSKQHMLQTNEKS", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more GPCR_2-like_7TM that are essential for its biological function; 2. The protein should belong to GPCR_2_secretin-like, GPCR_2_secretin-like, GPCR_2_secretin-like, GPCR_2_secretin-like, GPCR_2_secretin-like that shares evolutionary origin and functional similarity; 3. The protein should be classified within GAIN_dom_sf sharing conserved structural features; 4. The protein should contain GPS, GPS, GPS that is preserved across related proteins. The designed protein sequence is ", "reference": "MKQNPAKTARMWIIICLLFVLGQATDNDRDFKMCGKWLHGIAPQNLEYDLKTGCERIEISANESTLSIQGRITAKCTQSSSIQLDSNPHQNQSHFCVFWEPLLDLLIVEVNGKNHTLCKPNGLQGTCCTDLSQGVQDNAHMYGIVNGSVKGDIITGDLKGNYIFDGAHINCKEKFCDEARLKPRGANMIEEVVMRFNAKGRVDLPCAQGTVIEMDEEFTGHNFTVPAPRFVDANTIPSVYIPSSLRSVSRRKSKVVCTYYKNKTLFERGPSKSALLDDIVGLSVENETIRNLIEPVKIRFHHRPFAPDSSGRCVSWDTKQDNEVNWKDDGCDTVKINEEQTECHCNHLTYFAILVQVEQKSTVRHLKALTFITAVGCAVSLVSCLVLFYWLCKRRRGKKNQISLVHRGLVVAIFLLCLFFILTGILANVANETVCQLTGSLLHYGLLSTLCWMAMEVFHTFLLVRKVFNSPLPIWIFYLMGFGFPFLLVSILLSVGDIYGERKIKPSDDVNNPYRMCWMTEGDKSQLAHYIINIGLLAVVVSSGLVMLFLVVREIRNRPDWKKIHVAFLSIWGLTCLYGTTWALGFLDFGPFSEVTLFLFCIINSLQGFFLMLRYYALERMKKKDVSSSDGSSSGSSKQHMLQTNEKS" }, { "InterPro": [ { "InterPro-ID": "IPR038372", "InterPro-Name": "PA/PA-X_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1, "End": 198 }, { "InterPro-ID": "IPR001009", "InterPro-Name": "PA/PA-X", "InterPro-Type": "FAMILY", "Beg": 21, "End": 714 }, { "InterPro-ID": "IPR037534", "InterPro-Name": "INFV_PA", "InterPro-Type": "FAMILY", "Beg": 1, "End": 716 } ], "response#1": "MEDFVRQCFNPMIVELAEKAMKEYGEDPKIETNKFAAICTHLEVCFMYSDFHFIDERSESIIVESGDPNALLKHRFEIIEGRDRTMAWTVVNSICNTTGVEKPKFLPDLYDYKENRFIEIGVTRREVHTYYLEKANKIKSEETHIHIFSFTGEEMATKADYTLDEESRARIKTRLFTIRQEMASRGLWDSFRQSERGEETIEEKFEITGTMRRLADQSLPPNFSSLENFRAYVDGFEPNGCIEGKLSQMSKEVNARIEPFLKTTPRPLRLPDGPPCSQRSKFLLMDALKLSIEDPSHEGEGIPLYDAIKCMKTFFGWKEPNIVKPHEKGINPNYLLAWKQVLAELQDIENEEKIPKTKNMKKTSQLKWALGENMAPEKVDFEDCKDVSDLRQYDSDEPESRSLASWIQSEFNKACELTDSIWIELDEIGEDVAPIEHIASMRRNYFTAEVSHCRATEYIMKGVYINTALLNASCAAMDDFQLIPMISKCRTKEGRRKTNLYGFIIKGRSHLRNDTDVVNFVSMEFSLTDPRLEPHKWEKYCVLEIGDMLLRTAVGQVSRPMFLYVRTNGTSKIKMKWGMEMRRCLLQSLQQIESMIEAESSVKEKDMTKEFFENKSETWPIGESPKGVEEGSIGKVCRTLLAKSVFNSLYASPQLEGFSAESRKLLLIAQALRDNLEPGTFDLGGLYEAIEECLINDPWVLLNASWFNSFLAHALK", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to PA/PA-X, INFV_PA that shares evolutionary origin and functional similarity; 2. The protein should be classified within PA/PA-X_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MEDFVRQCFNPMIVELAEKAMKEYGEDPKIETNKFAAICTHLEVCFMYSDFHFIDERSESIIVESGDPNALLKHRFEIIEGRDRTMAWTVVNSICNTTGVEKPKFLPDLYDYKENRFIEIGVTRREVHTYYLEKANKIKSEETHIHIFSFTGEEMATKADYTLDEESRARIKTRLFTIRQEMASRGLWDSFRQSERGEETIEEKFEITGTMRRLADQSLPPNFSSLENFRAYVDGFEPNGCIEGKLSQMSKEVNARIEPFLKTTPRPLRLPDGPPCSQRSKFLLMDALKLSIEDPSHEGEGIPLYDAIKCMKTFFGWKEPNIVKPHEKGINPNYLLAWKQVLAELQDIENEEKIPKTKNMKKTSQLKWALGENMAPEKVDFEDCKDVSDLRQYDSDEPESRSLASWIQSEFNKACELTDSIWIELDEIGEDVAPIEHIASMRRNYFTAEVSHCRATEYIMKGVYINTALLNASCAAMDDFQLIPMISKCRTKEGRRKTNLYGFIIKGRSHLRNDTDVVNFVSMEFSLTDPRLEPHKWEKYCVLEIGDMLLRTAVGQVSRPMFLYVRTNGTSKIKMKWGMEMRRCLLQSLQQIESMIEAESSVKEKDMTKEFFENKSETWPIGESPKGVEEGSIGKVCRTLLAKSVFNSLYASPQLEGFSAESRKLLLIAQALRDNLEPGTFDLGGLYEAIEECLINDPWVLLNASWFNSFLAHALK" }, { "InterPro": [ { "InterPro-ID": "IPR003864", "InterPro-Name": "CSC1/OSCA1-like_7TM", "InterPro-Type": "DOMAIN", "Beg": 400, "End": 661 }, { "InterPro-ID": "IPR045122", "InterPro-Name": "Csc1-like", "InterPro-Type": "FAMILY", "Beg": 27, "End": 694 }, { "InterPro-ID": "IPR032880", "InterPro-Name": "Csc1/OSCA1-like_N", "InterPro-Type": "DOMAIN", "Beg": 110, "End": 219 }, { "InterPro-ID": "IPR027815", "InterPro-Name": "CSC1/OSCA1-like_cyt", "InterPro-Type": "DOMAIN", "Beg": 235, "End": 387 } ], "response#1": "MVMSENSNISYCQAVANRTSFFTTAYNGIPETLILNTIFWVLLILLFTVLRHQAGDFGRLALVNSNGSKKRWTEIFYSRAASVVDPQPSTSTQVSPRPSTTSQGVPDSTPLSPIQPEEGLFGWIRVTLKLRKETILLHTGPDAVHYLSFQQHLMAVMALVTIVSLVIILPVNFLNGPKENPYDVNAFGRTTMANLSPDSPWLWVHTIITILYIPLVVLIMRRASGRNAFKKAATRTIMISNISSSDRNKTVVRNYMQELFPDVTIENVSIAYNISRLYVRNAEFERVHEARLYCEHHRNRDTLMVKPEMCSCKKENAYEYYQREERKLSGDVARLRASTMNEPLDIAFITVSTVQEAQNIVTHFTPGTYRQWHLVFAPSPDDLFWENLNVNKSHWYLKFFCVNAVLFLVLFFLSTPAMVVSLLNSRPWVKETEGKISPLVADFLPTLMLWTLSALMPVIVAISDKWMRHYTRSKQNYSIMTKCFGYLLMMIMILPSLGLTSAQALLEWGFLNQTDRWQCIFLPDRGSFYVNYIITAAFIGTALELLRFPELIVYIWSLLKAKSKAETPYIRKAILIEFPFGTHYAWTTLVFTIAIVYSVACPLIMPFAMIYICLKHFVDRHNLYFAYGPSNMISRKGGKIHSTAVTMTKFSVVILVLVMAMICFFRGDNGMARFLLLIISLAITLTLFTFMSPIKRCAATRRPSIVEIAGPAPIYVPDVLKDNGIRTSSVRPSAAAFGGYGSDSVSEYDSSQYSVNSVEA", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more CSC1/OSCA1-like_7TM, Csc1/OSCA1-like_N, CSC1/OSCA1-like_cyt that are essential for its biological function; 2. The protein should belong to Csc1-like that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MVMSENSNISYCQAVANRTSFFTTAYNGIPETLILNTIFWVLLILLFTVLRHQAGDFGRLALVNSNGSKKRWTEIFYSRAASVVDPQPSTSTQVSPRPSTTSQGVPDSTPLSPIQPEEGLFGWIRVTLKLRKETILLHTGPDAVHYLSFQQHLMAVMALVTIVSLVIILPVNFLNGPKENPYDVNAFGRTTMANLSPDSPWLWVHTIITILYIPLVVLIMRRASGRNAFKKAATRTIMISNISSSDRNKTVVRNYMQELFPDVTIENVSIAYNISRLYVRNAEFERVHEARLYCEHHRNRDTLMVKPEMCSCKKENAYEYYQREERKLSGDVARLRASTMNEPLDIAFITVSTVQEAQNIVTHFTPGTYRQWHLVFAPSPDDLFWENLNVNKSHWYLKFFCVNAVLFLVLFFLSTPAMVVSLLNSRPWVKETEGKISPLVADFLPTLMLWTLSALMPVIVAISDKWMRHYTRSKQNYSIMTKCFGYLLMMIMILPSLGLTSAQALLEWGFLNQTDRWQCIFLPDRGSFYVNYIITAAFIGTALELLRFPELIVYIWSLLKAKSKAETPYIRKAILIEFPFGTHYAWTTLVFTIAIVYSVACPLIMPFAMIYICLKHFVDRHNLYFAYGPSNMISRKGGKIHSTAVTMTKFSVVILVLVMAMICFFRGDNGMARFLLLIISLAITLTLFTFMSPIKRCAATRRPSIVEIAGPAPIYVPDVLKDNGIRTSSVRPSAAAFGGYGSDSVSEYDSSQYSVNSVEA" }, { "InterPro": [ { "InterPro-ID": "IPR030492", "InterPro-Name": "RHD_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 34, "End": 40 }, { "InterPro-ID": "IPR000451", "InterPro-Name": "NFkB/Dor", "InterPro-Type": "FAMILY", "Beg": 13, "End": 442 }, { "InterPro-ID": "IPR032397", "InterPro-Name": "RHD_dimer", "InterPro-Type": "DOMAIN", "Beg": 195, "End": 291 }, { "InterPro-ID": "IPR013783", "InterPro-Name": "Ig-like_fold", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 191, "End": 304 }, { "InterPro-ID": "IPR002909", "InterPro-Name": "IPT_dom", "InterPro-Type": "DOMAIN", "Beg": 193, "End": 289 }, { "InterPro-ID": "IPR011539", "InterPro-Name": "RHD_DNA_bind_dom", "InterPro-Type": "DOMAIN", "Beg": 16, "End": 190 }, { "InterPro-ID": "IPR033926", "InterPro-Name": "IPT_NFkappaB", "InterPro-Type": "DOMAIN", "Beg": 194, "End": 290 }, { "InterPro-ID": "IPR011539", "InterPro-Name": "RHD_DNA_bind_dom", "InterPro-Type": "DOMAIN", "Beg": 21, "End": 186 }, { "InterPro-ID": "IPR030495", "InterPro-Name": "RelA_RHD_N", "InterPro-Type": "DOMAIN", "Beg": 19, "End": 187 }, { "InterPro-ID": "IPR000451", "InterPro-Name": "NFkB/Dor", "InterPro-Type": "FAMILY", "Beg": 208, "End": 228 }, { "InterPro-ID": "IPR000451", "InterPro-Name": "NFkB/Dor", "InterPro-Type": "FAMILY", "Beg": 239, "End": 257 }, { "InterPro-ID": "IPR000451", "InterPro-Name": "NFkB/Dor", "InterPro-Type": "FAMILY", "Beg": 175, "End": 189 }, { "InterPro-ID": "IPR000451", "InterPro-Name": "NFkB/Dor", "InterPro-Type": "FAMILY", "Beg": 280, "End": 294 }, { "InterPro-ID": "IPR000451", "InterPro-Name": "NFkB/Dor", "InterPro-Type": "FAMILY", "Beg": 25, "End": 42 }, { "InterPro-ID": "IPR008967", "InterPro-Name": "p53-like_TF_DNA-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 18, "End": 196 }, { "InterPro-ID": "IPR014756", "InterPro-Name": "Ig_E-set", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 191, "End": 322 }, { "InterPro-ID": "IPR037059", "InterPro-Name": "RHD_DNA_bind_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 9, "End": 187 } ], "response#1": "MDDLFPLIFPSEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPTIKINGYTGPGTVRISLVTKDPPHRPHPHELVGKDCRDGFYEAELCPDRCIHSFQNLGIQCVKKRDLEQAISQRIQTNNNPFQVPIEEQRGDYDLNAVRLCFQVTVRDPSGRPLRLTPVLSHPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGPGWEARGSFSQADVHRQVAIVFRTPPYADPSLQAPVRVSMQLRRPSDRELSEPMEFQYLPDTDDRHRIEEKRKRTYETFKSIMKKSPFNGPTEPRPPPRRIAVPSRGPTSVPKPAPQPYAFSTSLSTINFDEFSPMVLPPGQISNQALALAPSSAPVLAQTMVPSSAMVPSLAQPPAPVPVLAPGPPQSLSAPVPKSTQAGEGTLSEALLHLQFDADEDLGALLGNNTDPGVFTDLASVDNSEFQQLLNQGVAMSHSTAEPMLMEYPEAITRLVTGSQRPPDPAPATLGTSGLPNGLSGDEDFSSIADMDFSALLSQISS", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more RHD_dimer, IPT_dom, RHD_DNA_bind_dom, IPT_NFkappaB, RHD_DNA_bind_dom, RelA_RHD_N that are essential for its biological function; 2. The protein should belong to NFkB/Dor, NFkB/Dor, NFkB/Dor, NFkB/Dor, NFkB/Dor, NFkB/Dor that shares evolutionary origin and functional similarity; 3. The protein should be classified within Ig-like_fold, p53-like_TF_DNA-bd_sf, Ig_E-set, RHD_DNA_bind_dom_sf sharing conserved structural features; 4. The protein should contain RHD_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MDDLFPLIFPSEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPTIKINGYTGPGTVRISLVTKDPPHRPHPHELVGKDCRDGFYEAELCPDRCIHSFQNLGIQCVKKRDLEQAISQRIQTNNNPFQVPIEEQRGDYDLNAVRLCFQVTVRDPSGRPLRLTPVLSHPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGPGWEARGSFSQADVHRQVAIVFRTPPYADPSLQAPVRVSMQLRRPSDRELSEPMEFQYLPDTDDRHRIEEKRKRTYETFKSIMKKSPFNGPTEPRPPPRRIAVPSRGPTSVPKPAPQPYAFSTSLSTINFDEFSPMVLPPGQISNQALALAPSSAPVLAQTMVPSSAMVPSLAQPPAPVPVLAPGPPQSLSAPVPKSTQAGEGTLSEALLHLQFDADEDLGALLGNNTDPGVFTDLASVDNSEFQQLLNQGVAMSHSTAEPMLMEYPEAITRLVTGSQRPPDPAPATLGTSGLPNGLSGDEDFSSIADMDFSALLSQISS" }, { "InterPro": [ { "InterPro-ID": "IPR011545", "InterPro-Name": "DEAD/DEAH_box_helicase_dom", "InterPro-Type": "DOMAIN", "Beg": 96, "End": 243 }, { "InterPro-ID": "IPR001650", "InterPro-Name": "Helicase_C-like", "InterPro-Type": "DOMAIN", "Beg": 289, "End": 432 }, { "InterPro-ID": "IPR001650", "InterPro-Name": "Helicase_C-like", "InterPro-Type": "DOMAIN", "Beg": 292, "End": 397 }, { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 85, "End": 254 }, { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 109, "End": 408 }, { "InterPro-ID": "IPR001650", "InterPro-Name": "Helicase_C-like", "InterPro-Type": "DOMAIN", "Beg": 315, "End": 398 }, { "InterPro-ID": "IPR014001", "InterPro-Name": "Helicase_ATP-bd", "InterPro-Type": "DOMAIN", "Beg": 107, "End": 257 }, { "InterPro-ID": "IPR014001", "InterPro-Name": "Helicase_ATP-bd", "InterPro-Type": "DOMAIN", "Beg": 91, "End": 277 }, { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 276, "End": 431 }, { "InterPro-ID": "IPR050880", "InterPro-Name": "PriA_helicase", "InterPro-Type": "FAMILY", "Beg": 315, "End": 422 } ], "response#1": "MKVNLDYLGRLFTENELTEEERQLAEKLPAMRKEKGKLFCQRCNSTILEEWYLPIGAYYCRECLLMKRVRSDQTLYYFPQEDFPKQDVLKWRGQLTPFQEKVSEGLLQAVDKQKPTLVHAVTGAGKTEMIYQVVAKVINAGGAVCLASPRIDVCLELYKRLQQDFSCGIALLHGESEPYFRTPLVVATTHQLLKFYQAFDLLIVDEVDAFPYVDNPMLYHAVKNSVKENGLRIFLTATSTNELDKKVRLGELKRLNLPRRFHGNPLIIPKPIWLSDFNRYLDKNRLSPKLKSYIEKQRKTAYPLLIFASEIKKGEQLAEILQEQFPNEKIGFVSSVTEDRLEQVQAFRDGELTILISTTILERGVTFPCVDVFVVEANHRLFTKSSLIQIGGRVGRSMDRPTGDLLFFHDGLNASIKKAIKEIQMMNKEAGL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more DEAD/DEAH_box_helicase_dom, Helicase_C-like, Helicase_C-like, Helicase_C-like, Helicase_ATP-bd, Helicase_ATP-bd that are essential for its biological function; 2. The protein should belong to PriA_helicase that shares evolutionary origin and functional similarity; 3. The protein should be classified within P-loop_NTPase, P-loop_NTPase, P-loop_NTPase sharing conserved structural features. The designed protein sequence is ", "reference": "MKVNLDYLGRLFTENELTEEERQLAEKLPAMRKEKGKLFCQRCNSTILEEWYLPIGAYYCRECLLMKRVRSDQTLYYFPQEDFPKQDVLKWRGQLTPFQEKVSEGLLQAVDKQKPTLVHAVTGAGKTEMIYQVVAKVINAGGAVCLASPRIDVCLELYKRLQQDFSCGIALLHGESEPYFRTPLVVATTHQLLKFYQAFDLLIVDEVDAFPYVDNPMLYHAVKNSVKENGLRIFLTATSTNELDKKVRLGELKRLNLPRRFHGNPLIIPKPIWLSDFNRYLDKNRLSPKLKSYIEKQRKTAYPLLIFASEIKKGEQLAEILQEQFPNEKIGFVSSVTEDRLEQVQAFRDGELTILISTTILERGVTFPCVDVFVVEANHRLFTKSSLIQIGGRVGRSMDRPTGDLLFFHDGLNASIKKAIKEIQMMNKEAGL" }, { "InterPro": [ { "InterPro-ID": "IPR050793", "InterPro-Name": "CMP-NeuNAc_synthase", "InterPro-Type": "FAMILY", "Beg": 2, "End": 239 }, { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 217, "End": 377 }, { "InterPro-ID": "IPR003329", "InterPro-Name": "Cytidylyl_trans", "InterPro-Type": "FAMILY", "Beg": 3, "End": 225 }, { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 222, "End": 388 }, { "InterPro-ID": "IPR002891", "InterPro-Name": "APS_kinase", "InterPro-Type": "FAMILY", "Beg": 225, "End": 370 }, { "InterPro-ID": "IPR029044", "InterPro-Name": "Nucleotide-diphossugar_trans", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1, "End": 221 }, { "InterPro-ID": "IPR029044", "InterPro-Name": "Nucleotide-diphossugar_trans", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 2, "End": 218 } ], "response#1": "MVIAVIPARSGSKGIKNKNLVLLNNQPLIYYTIKAALNSKCISKVLVSSDSEEILSYAKSQNVDILKRPIELAQDDTTSDKVLLHALEFYKDYEDVIFLQPTSPLRTNIHIDEAFKIYKNSDANALISVTECDNKILKAFICDNKGDLKGICDDEYPFMPRQKLPKTYMSNGAIYILSIKDFLNKPSFLQSKTKYFLMNKISSLDIDNLEDLKQVENIQKMKGCVVWISGLAGAGKTTISSGLYKKLKEKYNNSVLLDGDELRKIFKHTGYTREERLESAKKISSLCSFLAKNDIIVICATISLFEEIYLLNRNTIENYFEVFVDCPMEELILRDQKGLYSGALKGEIKDVVGVDIKYAKPNAHYIIDNSSKTDLEKKINNLYNEVELFFNKER", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to CMP-NeuNAc_synthase, Cytidylyl_trans, APS_kinase that shares evolutionary origin and functional similarity; 2. The protein should be classified within P-loop_NTPase, P-loop_NTPase, Nucleotide-diphossugar_trans, Nucleotide-diphossugar_trans sharing conserved structural features. The designed protein sequence is ", "reference": "MVIAVIPARSGSKGIKNKNLVLLNNQPLIYYTIKAALNSKCISKVLVSSDSEEILSYAKSQNVDILKRPIELAQDDTTSDKVLLHALEFYKDYEDVIFLQPTSPLRTNIHIDEAFKIYKNSDANALISVTECDNKILKAFICDNKGDLKGICDDEYPFMPRQKLPKTYMSNGAIYILSIKDFLNKPSFLQSKTKYFLMNKISSLDIDNLEDLKQVENIQKMKGCVVWISGLAGAGKTTISSGLYKKLKEKYNNSVLLDGDELRKIFKHTGYTREERLESAKKISSLCSFLAKNDIIVICATISLFEEIYLLNRNTIENYFEVFVDCPMEELILRDQKGLYSGALKGEIKDVVGVDIKYAKPNAHYIIDNSSKTDLEKKINNLYNEVELFFNKER" }, { "InterPro": [ { "InterPro-ID": "IPR051690", "InterPro-Name": "Nonulosonic_Acid_Synth", "InterPro-Type": "FAMILY", "Beg": 1, "End": 345 }, { "InterPro-ID": "IPR013785", "InterPro-Name": "Aldolase_TIM", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 3, "End": 271 }, { "InterPro-ID": "IPR006190", "InterPro-Name": "AFP_Neu5c_C", "InterPro-Type": "DOMAIN", "Beg": 289, "End": 346 }, { "InterPro-ID": "IPR020007", "InterPro-Name": "N-AcNeuraminate_synthase", "InterPro-Type": "FAMILY", "Beg": 18, "End": 340 }, { "InterPro-ID": "IPR036732", "InterPro-Name": "AFP_Neu5c_C_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 279, "End": 345 }, { "InterPro-ID": "IPR013132", "InterPro-Name": "Neu5Ac_N", "InterPro-Type": "DOMAIN", "Beg": 37, "End": 270 }, { "InterPro-ID": "IPR013974", "InterPro-Name": "SAF", "InterPro-Type": "DOMAIN", "Beg": 287, "End": 346 }, { "InterPro-ID": "IPR013974", "InterPro-Name": "SAF", "InterPro-Type": "DOMAIN", "Beg": 289, "End": 345 } ], "response#1": "MKEIKIQNIIINEEKAPLVVPEIGINHNGSLELAKIMVDAAFSAGAKIIKHQTHIVEDEMSKAAKKVIPGNAKISIYEIMQKCALDYKDELALKEYTEKLGLVYLSTPFSRAGANRLEDMGVSAFKIGSGECNNYPLIKHIAAFKKPMIVSTGMNSIESIKPTVKILLDNEIPFVLMHTTNLYPTPHNLVRLNAMLELKKEFSCMVGLSDHTTDNLACLGAVALGACVLERHFTDSMDRSGPDIVCSMDTKALKELIMQSEQMAIMRGNNESKKAAKQEQVTIDFAFASVVSIKDIKKGEVLSMDNIWVKRPGLGGISAAEFENILGKKALRDIENDTQLSYEDFA", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more AFP_Neu5c_C, Neu5Ac_N, SAF, SAF that are essential for its biological function; 2. The protein should belong to Nonulosonic_Acid_Synth, N-AcNeuraminate_synthase that shares evolutionary origin and functional similarity; 3. The protein should be classified within Aldolase_TIM, AFP_Neu5c_C_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MKEIKIQNIIINEEKAPLVVPEIGINHNGSLELAKIMVDAAFSAGAKIIKHQTHIVEDEMSKAAKKVIPGNAKISIYEIMQKCALDYKDELALKEYTEKLGLVYLSTPFSRAGANRLEDMGVSAFKIGSGECNNYPLIKHIAAFKKPMIVSTGMNSIESIKPTVKILLDNEIPFVLMHTTNLYPTPHNLVRLNAMLELKKEFSCMVGLSDHTTDNLACLGAVALGACVLERHFTDSMDRSGPDIVCSMDTKALKELIMQSEQMAIMRGNNESKKAAKQEQVTIDFAFASVVSIKDIKKGEVLSMDNIWVKRPGLGGISAAEFENILGKKALRDIENDTQLSYEDFA" }, { "InterPro": [ { "InterPro-ID": "IPR029767", "InterPro-Name": "WecB-like", "InterPro-Type": "FAMILY", "Beg": 1, "End": 335 }, { "InterPro-ID": "IPR020004", "InterPro-Name": "UDP-GlcNAc_Epase", "InterPro-Type": "FAMILY", "Beg": 2, "End": 334 }, { "InterPro-ID": "IPR003331", "InterPro-Name": "UDP_GlcNAc_Epimerase_2_dom", "InterPro-Type": "DOMAIN", "Beg": 24, "End": 335 } ], "response#1": "MKKILFITGTRADYSKIKSLMYRVQNSSEFELCIFATGMHLSKNFGYTVKELYKNGFKNIYEFINYDKYYQTDKALATTIDGFSRYVNELKPDLIVVHGDRIEPLAAAIVGALNNILVAHIEGGEISGTIDDSLRHAISKLAHIHLVNDEFAKKRLMQLGEDEKSIFIIGSPDLELLNDNKISLNEAKKYYDINYENYALLMFHPVTTEITSIKNQADNLVKALIQSNKNYIVIYPNNDLGFELILQSYEELKNNPRFKLFPSLRFEYFITLLKNADFIIGNSSCILKEALYLKTAGILVGSRQNGRLGNENTLKVNANSDEILKAINTIHKKQDLFSAKLEILDSSKLFFEYLQSGEFFKLSTQKVFKDIII", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more UDP_GlcNAc_Epimerase_2_dom that are essential for its biological function; 2. The protein should belong to WecB-like, UDP-GlcNAc_Epase that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MKKILFITGTRADYSKIKSLMYRVQNSSEFELCIFATGMHLSKNFGYTVKELYKNGFKNIYEFINYDKYYQTDKALATTIDGFSRYVNELKPDLIVVHGDRIEPLAAAIVGALNNILVAHIEGGEISGTIDDSLRHAISKLAHIHLVNDEFAKKRLMQLGEDEKSIFIIGSPDLELLNDNKISLNEAKKYYDINYENYALLMFHPVTTEITSIKNQADNLVKALIQSNKNYIVIYPNNDLGFELILQSYEELKNNPRFKLFPSLRFEYFITLLKNADFIIGNSSCILKEALYLKTAGILVGSRQNGRLGNENTLKVNANSDEILKAINTIHKKQDLFSAKLEILDSSKLFFEYLQSGEFFKLSTQKVFKDIII" }, { "InterPro": [ { "InterPro-ID": "IPR051697", "InterPro-Name": "Patched_domain-protein", "InterPro-Type": "FAMILY", "Beg": 15, "End": 1468 }, { "InterPro-ID": "IPR000731", "InterPro-Name": "SSD", "InterPro-Type": "DOMAIN", "Beg": 494, "End": 653 }, { "InterPro-ID": "IPR003392", "InterPro-Name": "PTHD_SSD", "InterPro-Type": "DOMAIN", "Beg": 504, "End": 651 } ], "response#1": "MFVKNFIHKLKELKQKSLDKFANLLYDYGGYVYDRPCTFIICSLICCLLLTCGFYFKEHEKDIYKLYSISNSYAYETNETINDFFYKSRRCFILVESNVNLLKPKILRELQKFEEGTKDIEVDLSEINECKTNSELPPEQSHVAKELYKTLIQRSEENLKSGKINGSLFDYSDLDENGKSVLSLAGKENNDDTLIEGDNKNDEETSANNNNNEDDNNEDDNNEDDNNEDDNNENDNNNNNEDDNNNDDDDDEDNEEEDEEKQKSLREKLYRKIYEMLKKKKENIVLDENNPNVNFTDYKDDVFYPYQYIPPMLIKADRCKLQNVFGDKNLNIDLREASDGLKKQITYTLEDICEKKYGDCNFSSLFLYYEKGNGYIDYPIKVDNLDFYVNRRTYKEMMFKGILGNMVYEKSGSKYIIKSANAIMTVIPLLNSHTYEPYALAYEKKLIDYVRFYNLDDIIQDEETNDDNDPFIRFHVFTDRSLEDEVDRISKIDNLTRLLLLIGVLLIFMYALFNNVTSVLYRSKPLCAVMGIFCGFLGFLSGSGFLYFLGVKSVPPAETVPFLVIGVGVDDVFVILNSYSLLFMVKDNKKRIQMCLKDSALAITVTTLTNIIAFLISAISPFYSICAFSLFTASSLFFGYLMVLTFLLSFLCIEAKLEKKKRNIFTGTFHLFRSIFMKSSKKNKKENKENNIHDDGDNDNDEKKKDLSLEVKNNEDDYENISIYEWIHNLYLFEESINKKKKNAALVYASNNGMSSNLNNVNEDGFPNPSKIVSMEDVKKRNIKKDDAYINKEDEEGGGYYNKDDNKKKDILGKKQKKNNNNVTLVSKKGEDNELDVYYENLDEKTNDKYKMNNIKSSKLKYDNDKKDGAIINNRPSSDEEYKEEKDKNKINILNDVFNDITIKPNENILLDRGDVIKSSGYDSSYNDLQSSSLPNPSSNEVLNKTTMVYNETDLKDNKKEIKSSKKNVKDIKKSDMIHDDTYDIINSNNKNILLSSNEINNNSNNTNKFNNNSTELATKDTQQFINGHDKNIYLLSSHDNALFYKYIYEEPKGNIGKYFRSLVKNYYVPFLSSRFGKTIVYIMFTIIIAMSIYGCTLMKKGIKYDKAFPVDSYVRRFTTAKIKYFPDFGDFIEVYYFDKHFINKYRGLEKNTKEAASSFLYSDLTDRQIMNSPKINKNVHWENTNLQEELINMHNTLESQEFVTSVANGFTFFLNKNKSSLRKENPQEFYEIFANWLKKDFVGNLFKNDFVFLNGKLVAWRFHYFQKNVDDSEISSKWLKACKQITKLENHNVQMVCFHLSSIFNETDESIIEVTLINLGITILTILVVTAYIIKGFYSCVIIALIIFLIDLCIFGFMCLCGITMNIISMVILVLSVGFSIDHTSHIVQAFSHSMGRTRDEKMKESLHLMIGPVLHSGLSTWFVISTLFFSNKDFTVIFFQTLSLVLFFSITFSSMFLPVLLSSFGPLH", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more SSD, PTHD_SSD that are essential for its biological function; 2. The protein should belong to Patched_domain-protein that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MFVKNFIHKLKELKQKSLDKFANLLYDYGGYVYDRPCTFIICSLICCLLLTCGFYFKEHEKDIYKLYSISNSYAYETNETINDFFYKSRRCFILVESNVNLLKPKILRELQKFEEGTKDIEVDLSEINECKTNSELPPEQSHVAKELYKTLIQRSEENLKSGKINGSLFDYSDLDENGKSVLSLAGKENNDDTLIEGDNKNDEETSANNNNNEDDNNEDDNNEDDNNEDDNNENDNNNNNEDDNNNDDDDDEDNEEEDEEKQKSLREKLYRKIYEMLKKKKENIVLDENNPNVNFTDYKDDVFYPYQYIPPMLIKADRCKLQNVFGDKNLNIDLREASDGLKKQITYTLEDICEKKYGDCNFSSLFLYYEKGNGYIDYPIKVDNLDFYVNRRTYKEMMFKGILGNMVYEKSGSKYIIKSANAIMTVIPLLNSHTYEPYALAYEKKLIDYVRFYNLDDIIQDEETNDDNDPFIRFHVFTDRSLEDEVDRISKIDNLTRLLLLIGVLLIFMYALFNNVTSVLYRSKPLCAVMGIFCGFLGFLSGSGFLYFLGVKSVPPAETVPFLVIGVGVDDVFVILNSYSLLFMVKDNKKRIQMCLKDSALAITVTTLTNIIAFLISAISPFYSICAFSLFTASSLFFGYLMVLTFLLSFLCIEAKLEKKKRNIFTGTFHLFRSIFMKSSKKNKKENKENNIHDDGDNDNDEKKKDLSLEVKNNEDDYENISIYEWIHNLYLFEESINKKKKNAALVYASNNGMSSNLNNVNEDGFPNPSKIVSMEDVKKRNIKKDDAYINKEDEEGGGYYNKDDNKKKDILGKKQKKNNNNVTLVSKKGEDNELDVYYENLDEKTNDKYKMNNIKSSKLKYDNDKKDGAIINNRPSSDEEYKEEKDKNKINILNDVFNDITIKPNENILLDRGDVIKSSGYDSSYNDLQSSSLPNPSSNEVLNKTTMVYNETDLKDNKKEIKSSKKNVKDIKKSDMIHDDTYDIINSNNKNILLSSNEINNNSNNTNKFNNNSTELATKDTQQFINGHDKNIYLLSSHDNALFYKYIYEEPKGNIGKYFRSLVKNYYVPFLSSRFGKTIVYIMFTIIIAMSIYGCTLMKKGIKYDKAFPVDSYVRRFTTAKIKYFPDFGDFIEVYYFDKHFINKYRGLEKNTKEAASSFLYSDLTDRQIMNSPKINKNVHWENTNLQEELINMHNTLESQEFVTSVANGFTFFLNKNKSSLRKENPQEFYEIFANWLKKDFVGNLFKNDFVFLNGKLVAWRFHYFQKNVDDSEISSKWLKACKQITKLENHNVQMVCFHLSSIFNETDESIIEVTLINLGITILTILVVTAYIIKGFYSCVIIALIIFLIDLCIFGFMCLCGITMNIISMVILVLSVGFSIDHTSHIVQAFSHSMGRTRDEKMKESLHLMIGPVLHSGLSTWFVISTLFFSNKDFTVIFFQTLSLVLFFSITFSSMFLPVLLSSFGPLH" }, { "InterPro": [ { "InterPro-ID": "IPR016580", "InterPro-Name": "Cell_cycle_HUS1", "InterPro-Type": "FAMILY", "Beg": 1, "End": 278 }, { "InterPro-ID": "IPR007150", "InterPro-Name": "Hus1/Mec3", "InterPro-Type": "FAMILY", "Beg": 1, "End": 276 } ], "response#1": "MKFRALMQDPLYMKEFQAIVATLTKLAKDCVMILGSRQMHFIVNEDQSSAASPLVWAGITAEEYFPEYRMEAAHPDQEYIVLGVSSANLGRALSVLRGGGVNSCKLKLQRIQFPCISVIASVLTSSSTEAREVVHDVPVTIIPGSDWSAYVVPRVPNSQLALGLPSLRLLKSLIDKLKNISPSLEFQVNVDGELNVIATSEMSTVTSRFQKLLIRTVSGSQQEASCSVDSRKASAFFGALQLPNEELTIGIDREHSIHLQIDVRQDVVLHSILPAVCM", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Cell_cycle_HUS1, Hus1/Mec3 that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MKFRALMQDPLYMKEFQAIVATLTKLAKDCVMILGSRQMHFIVNEDQSSAASPLVWAGITAEEYFPEYRMEAAHPDQEYIVLGVSSANLGRALSVLRGGGVNSCKLKLQRIQFPCISVIASVLTSSSTEAREVVHDVPVTIIPGSDWSAYVVPRVPNSQLALGLPSLRLLKSLIDKLKNISPSLEFQVNVDGELNVIATSEMSTVTSRFQKLLIRTVSGSQQEASCSVDSRKASAFFGALQLPNEELTIGIDREHSIHLQIDVRQDVVLHSILPAVCM" }, { "InterPro": [ { "InterPro-ID": "IPR046350", "InterPro-Name": "Cystatin_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 29, "End": 135 }, { "InterPro-ID": "IPR000010", "InterPro-Name": "Cystatin_dom", "InterPro-Type": "DOMAIN", "Beg": 34, "End": 123 }, { "InterPro-ID": "IPR000010", "InterPro-Name": "Cystatin_dom", "InterPro-Type": "DOMAIN", "Beg": 30, "End": 134 }, { "InterPro-ID": "IPR000010", "InterPro-Name": "Cystatin_dom", "InterPro-Type": "DOMAIN", "Beg": 27, "End": 135 } ], "response#1": "MAFFKSAVFLVCVVLAAAGSASRSKRALVGGWKTQDPTNPKFENLAHYAVSTQVEGREYYDTVLELLEVQTQIVAGVNYKLKFTTTQSTCKIETGVEYSKELCQPKTNKVEAVCTSIIYTVPWQNIKRVLSYHCDAPNDV", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Cystatin_dom, Cystatin_dom, Cystatin_dom that are essential for its biological function; 2. The protein should be classified within Cystatin_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MAFFKSAVFLVCVVLAAAGSASRSKRALVGGWKTQDPTNPKFENLAHYAVSTQVEGREYYDTVLELLEVQTQIVAGVNYKLKFTTTQSTCKIETGVEYSKELCQPKTNKVEAVCTSIIYTVPWQNIKRVLSYHCDAPNDV" }, { "InterPro": [ { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 33, "End": 107 }, { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 33, "End": 110 }, { "InterPro-ID": "IPR019778", "InterPro-Name": "Hydrophobin_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 84, "End": 95 } ], "response#1": "MLFKQLILVATALTTLAVATPAVMRRTEPASSCSTGPVNCCNSSGTAKDGNIAKELALLGIVVPDINALIGVSCSPITVIGAGGASCSSQTLCCEDNKYNGIVALGCIPVDISL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Hydrophobin, Hydrophobin that shares evolutionary origin and functional similarity; 2. The protein should contain Hydrophobin_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MLFKQLILVATALTTLAVATPAVMRRTEPASSCSTGPVNCCNSSGTAKDGNIAKELALLGIVVPDINALIGVSCSPITVIGAGGASCSSQTLCCEDNKYNGIVALGCIPVDISL" }, { "InterPro": [ { "InterPro-ID": "IPR010636", "InterPro-Name": "Cerato-ulmin_hydrophobin", "InterPro-Type": "FAMILY", "Beg": 360, "End": 420 }, { "InterPro-ID": "IPR010636", "InterPro-Name": "Cerato-ulmin_hydrophobin", "InterPro-Type": "FAMILY", "Beg": 233, "End": 296 }, { "InterPro-ID": "IPR036686", "InterPro-Name": "Hydrophobin_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 351, "End": 423 }, { "InterPro-ID": "IPR036686", "InterPro-Name": "Hydrophobin_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 128, "End": 201 }, { "InterPro-ID": "IPR036686", "InterPro-Name": "Hydrophobin_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 465, "End": 536 }, { "InterPro-ID": "IPR036686", "InterPro-Name": "Hydrophobin_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 229, "End": 301 }, { "InterPro-ID": "IPR036686", "InterPro-Name": "Hydrophobin_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 355, "End": 422 }, { "InterPro-ID": "IPR036686", "InterPro-Name": "Hydrophobin_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 233, "End": 300 }, { "InterPro-ID": "IPR036686", "InterPro-Name": "Hydrophobin_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 470, "End": 535 }, { "InterPro-ID": "IPR036686", "InterPro-Name": "Hydrophobin_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 133, "End": 200 }, { "InterPro-ID": "IPR010636", "InterPro-Name": "Cerato-ulmin_hydrophobin", "InterPro-Type": "FAMILY", "Beg": 470, "End": 533 }, { "InterPro-ID": "IPR010636", "InterPro-Name": "Cerato-ulmin_hydrophobin", "InterPro-Type": "FAMILY", "Beg": 134, "End": 198 }, { "InterPro-ID": "IPR010636", "InterPro-Name": "Cerato-ulmin_hydrophobin", "InterPro-Type": "FAMILY", "Beg": 356, "End": 420 }, { "InterPro-ID": "IPR010636", "InterPro-Name": "Cerato-ulmin_hydrophobin", "InterPro-Type": "FAMILY", "Beg": 471, "End": 534 }, { "InterPro-ID": "IPR010636", "InterPro-Name": "Cerato-ulmin_hydrophobin", "InterPro-Type": "FAMILY", "Beg": 234, "End": 298 }, { "InterPro-ID": "IPR010636", "InterPro-Name": "Cerato-ulmin_hydrophobin", "InterPro-Type": "FAMILY", "Beg": 134, "End": 196 }, { "InterPro-ID": "IPR010636", "InterPro-Name": "Cerato-ulmin_hydrophobin", "InterPro-Type": "FAMILY", "Beg": 360, "End": 419 } ], "response#1": "MKFITVAAALFASTSLAVPTNPNHGGSACVPNPHHGGSSTKSGPGGNPTGGNPTGSNTNTGPGGNPTGSNTSSSPGTRTTGGSTSSNPGPKPTSSNTRSGPATTTTGTKTGSNTSSGPATTSTGNPGPGGEFHCPRGLYSNLQCCATDVLGVVDLDCASPPTTPTSGDNFNAICAAVGKQAKCCVLPVAGQAALCQNPIGGNPPGGNPPGGNPPGGNPPGGNPPGGNPPGGPVCPSGLYSNAQCCATDVLGVADLNCDTPSKTPTSGADFTAICAASGQQAKCCVIPVAGQALLCENPTGGNPPGGNPPGGNPPGGNPPGGNPPGGNPPGGNPPGGNPTSSAPGSNPTNPPGGPVCPPGLYSNAQCCAVDVLGLADLDCDTPSQTPTSSADFRSICAADGQAAKCCVIPVAGQALLCQDPLGGNPPGGNPPGSSNPPGGSNPPGGSNPPGGSNPPGGNPPGGNPPGGNHVCPSGLYSNAQCCDVNVLGVANLNCAPPSTKPTSGKNFESICAAIGKGSMCCVVPLLGQAILCQRAII", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Cerato-ulmin_hydrophobin, Cerato-ulmin_hydrophobin, Cerato-ulmin_hydrophobin, Cerato-ulmin_hydrophobin, Cerato-ulmin_hydrophobin, Cerato-ulmin_hydrophobin, Cerato-ulmin_hydrophobin, Cerato-ulmin_hydrophobin, Cerato-ulmin_hydrophobin that shares evolutionary origin and functional similarity; 2. The protein should be classified within Hydrophobin_sf, Hydrophobin_sf, Hydrophobin_sf, Hydrophobin_sf, Hydrophobin_sf, Hydrophobin_sf, Hydrophobin_sf, Hydrophobin_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MKFITVAAALFASTSLAVPTNPNHGGSACVPNPHHGGSSTKSGPGGNPTGGNPTGSNTNTGPGGNPTGSNTSSSPGTRTTGGSTSSNPGPKPTSSNTRSGPATTTTGTKTGSNTSSGPATTSTGNPGPGGEFHCPRGLYSNLQCCATDVLGVVDLDCASPPTTPTSGDNFNAICAAVGKQAKCCVLPVAGQAALCQNPIGGNPPGGNPPGGNPPGGNPPGGNPPGGNPPGGPVCPSGLYSNAQCCATDVLGVADLNCDTPSKTPTSGADFTAICAASGQQAKCCVIPVAGQALLCENPTGGNPPGGNPPGGNPPGGNPPGGNPPGGNPPGGNPPGGNPTSSAPGSNPTNPPGGPVCPPGLYSNAQCCAVDVLGLADLDCDTPSQTPTSSADFRSICAADGQAAKCCVIPVAGQALLCQDPLGGNPPGGNPPGSSNPPGGSNPPGGSNPPGGSNPPGGNPPGGNPPGGNHVCPSGLYSNAQCCDVNVLGVANLNCAPPSTKPTSGKNFESICAAIGKGSMCCVVPLLGQAILCQRAII" }, { "InterPro": [ { "InterPro-ID": "IPR010636", "InterPro-Name": "Cerato-ulmin_hydrophobin", "InterPro-Type": "FAMILY", "Beg": 5, "End": 101 }, { "InterPro-ID": "IPR010636", "InterPro-Name": "Cerato-ulmin_hydrophobin", "InterPro-Type": "FAMILY", "Beg": 37, "End": 99 }, { "InterPro-ID": "IPR010636", "InterPro-Name": "Cerato-ulmin_hydrophobin", "InterPro-Type": "FAMILY", "Beg": 38, "End": 102 }, { "InterPro-ID": "IPR036686", "InterPro-Name": "Hydrophobin_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 32, "End": 105 }, { "InterPro-ID": "IPR036686", "InterPro-Name": "Hydrophobin_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 37, "End": 105 } ], "response#1": "MQVLLIATLVASVLAAPTEVSPQTSGGGGGGGGGGGVCRGFLYSNPICCATDILGLACLDGDTPPETPRDAKNFKEICAKNGQQARCCVLPIIDQAVLCIRPLGV", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Cerato-ulmin_hydrophobin, Cerato-ulmin_hydrophobin, Cerato-ulmin_hydrophobin that shares evolutionary origin and functional similarity; 2. The protein should be classified within Hydrophobin_sf, Hydrophobin_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MQVLLIATLVASVLAAPTEVSPQTSGGGGGGGGGGGVCRGFLYSNPICCATDILGLACLDGDTPPETPRDAKNFKEICAKNGQQARCCVLPIIDQAVLCIRPLGV" }, { "InterPro": [ { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 26, "End": 102 }, { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 26, "End": 99 } ], "response#1": "MFASTVFVSLLAVAAAVPTNPQGQSCGNGNTVHCCNAETANKLTKGGILGALDLSNLLGQCNDVTAAVAGGAVPIKNTCSSQAVCCGEIHQNGLVNLGCTPIFV", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Hydrophobin, Hydrophobin that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MFASTVFVSLLAVAAAVPTNPQGQSCGNGNTVHCCNAETANKLTKGGILGALDLSNLLGQCNDVTAAVAGGAVPIKNTCSSQAVCCGEIHQNGLVNLGCTPIFV" }, { "InterPro": [ { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 40, "End": 130 }, { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 40, "End": 133 } ], "response#1": "MRFFLAITALVAAVTAAPSADVAAVNQMAAMTLAEADASCGNGASLYCCDKSKQGGDTGSPGQAGGVGLLGAIVGVNGLLQGLLGQCSKININAIGAAGVLNQECTARAACCQNTPSVAHHGLVNIALPCIPINSLVG", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Hydrophobin, Hydrophobin that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MRFFLAITALVAAVTAAPSADVAAVNQMAAMTLAEADASCGNGASLYCCDKSKQGGDTGSPGQAGGVGLLGAIVGVNGLLQGLLGQCSKININAIGAAGVLNQECTARAACCQNTPSVAHHGLVNIALPCIPINSLVG" }, { "InterPro": [ { "InterPro-ID": "IPR013655", "InterPro-Name": "PAS_fold_3", "InterPro-Type": "DOMAIN", "Beg": 497, "End": 573 }, { "InterPro-ID": "IPR000014", "InterPro-Name": "PAS", "InterPro-Type": "DOMAIN", "Beg": 281, "End": 348 }, { "InterPro-ID": "IPR000014", "InterPro-Name": "PAS", "InterPro-Type": "DOMAIN", "Beg": 592, "End": 658 }, { "InterPro-ID": "IPR000014", "InterPro-Name": "PAS", "InterPro-Type": "DOMAIN", "Beg": 474, "End": 540 }, { "InterPro-ID": "IPR035965", "InterPro-Name": "PAS-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 479, "End": 576 }, { "InterPro-ID": "IPR000014", "InterPro-Name": "PAS", "InterPro-Type": "DOMAIN", "Beg": 479, "End": 542 }, { "InterPro-ID": "IPR035965", "InterPro-Name": "PAS-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 608, "End": 693 }, { "InterPro-ID": "IPR000014", "InterPro-Name": "PAS", "InterPro-Type": "DOMAIN", "Beg": 483, "End": 579 }, { "InterPro-ID": "IPR000014", "InterPro-Name": "PAS", "InterPro-Type": "DOMAIN", "Beg": 306, "End": 328 }, { "InterPro-ID": "IPR000679", "InterPro-Name": "Znf_GATA", "InterPro-Type": "DOMAIN", "Beg": 811, "End": 836 }, { "InterPro-ID": "IPR000679", "InterPro-Name": "Znf_GATA", "InterPro-Type": "DOMAIN", "Beg": 810, "End": 842 }, { "InterPro-ID": "IPR000679", "InterPro-Name": "Znf_GATA", "InterPro-Type": "DOMAIN", "Beg": 805, "End": 855 }, { "InterPro-ID": "IPR000014", "InterPro-Name": "PAS", "InterPro-Type": "DOMAIN", "Beg": 303, "End": 406 }, { "InterPro-ID": "IPR000014", "InterPro-Name": "PAS", "InterPro-Type": "DOMAIN", "Beg": 478, "End": 573 }, { "InterPro-ID": "IPR013088", "InterPro-Name": "Znf_NHR/GATA", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 805, "End": 850 }, { "InterPro-ID": "IPR000014", "InterPro-Name": "PAS", "InterPro-Type": "DOMAIN", "Beg": 603, "End": 695 }, { "InterPro-ID": "IPR000679", "InterPro-Name": "Znf_GATA", "InterPro-Type": "DOMAIN", "Beg": 811, "End": 843 }, { "InterPro-ID": "IPR000014", "InterPro-Name": "PAS", "InterPro-Type": "DOMAIN", "Beg": 295, "End": 406 }, { "InterPro-ID": "IPR000014", "InterPro-Name": "PAS", "InterPro-Type": "DOMAIN", "Beg": 611, "End": 692 }, { "InterPro-ID": "IPR035965", "InterPro-Name": "PAS-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 293, "End": 405 }, { "InterPro-ID": "IPR000679", "InterPro-Name": "Znf_GATA", "InterPro-Type": "DOMAIN", "Beg": 805, "End": 838 }, { "InterPro-ID": "IPR000014", "InterPro-Name": "PAS", "InterPro-Type": "DOMAIN", "Beg": 299, "End": 406 } ], "response#1": "MEGFSDGYYDAQYTVPASDHRVEYPLSSSDHYAQAMMPFATPDQMHAAGFAYQSQIPDLVANSASFVFPSHTAGLSLNLPEHPMPAENLGDRTSNAMLLYDPLSALGGSTPTAINTGDPFAYNAFQSPFPAMSLENFQGQQSLSFHNTCLPSQPMNLNPSVAYSTMQTHGPILNTYQAPPRHAELTTSAKPTGTLDKQPSTNFPQPAGQTSQRRRNRGFQSSGPTPTHRFIQPKRPSPTKAPLPPHPKSAAGETSQYASIYSSSGFDIMGVLAEVVSRPNPKINIGAVDLSCAFVLCDITQNDHPIIYVSEAFERLTGYTEQEIVGQNCRFLQGPEGVVQKGMKRTFVDDETTSRLRSTIEDRTEIQASLINYRKGGQPFMNLITMIPIRWSSQEYRFYVGFQVDLVETPDAVTRRNPNGTYTINYQRSRLPNYVVPPPDLYRSHPDLTTWFTTDQVSTILKSLNNSTLTYRNYLDRVLVENTDDIIHALSLEGEFLYLSPSCRKVLEYEPIELVGKTLSTVCHPSDIGPVIRDLRACTTTDPVSVVFRIRKKYSGYIWFESHGSWRMGERGRQFMVLVGRPRFVYCLDHIASIGHGSLAETDVWAKLSKSGIVLFMTSKARPVLGRMPDELIGKSLQDLMDSRAEAQKALGVARTGQRVTFSHKIRHKKGHMLPAQTTLHPGDTKEGVRPSFLVAHISFPKPPQGGNDELNSAPPPNRNLAVSKIHRQAVSGVSGVAGQNMLASVKQANPQIQKLPFFTELVPTRGSSWQVELRELEKQNRTLSDELQKLLTRRKKRKRKQSTASVEKSCAICQTKKTPEWRRGPSGERDLCNSCGLRWAKQVRNAAQVAGRPNAY", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more PAS_fold_3, PAS, PAS, PAS, PAS, PAS, PAS, Znf_GATA, Znf_GATA, Znf_GATA, PAS, PAS, PAS, Znf_GATA, PAS, PAS, Znf_GATA, PAS that are essential for its biological function; 2. The protein should be classified within PAS-like_dom_sf, PAS-like_dom_sf, Znf_NHR/GATA, PAS-like_dom_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MEGFSDGYYDAQYTVPASDHRVEYPLSSSDHYAQAMMPFATPDQMHAAGFAYQSQIPDLVANSASFVFPSHTAGLSLNLPEHPMPAENLGDRTSNAMLLYDPLSALGGSTPTAINTGDPFAYNAFQSPFPAMSLENFQGQQSLSFHNTCLPSQPMNLNPSVAYSTMQTHGPILNTYQAPPRHAELTTSAKPTGTLDKQPSTNFPQPAGQTSQRRRNRGFQSSGPTPTHRFIQPKRPSPTKAPLPPHPKSAAGETSQYASIYSSSGFDIMGVLAEVVSRPNPKINIGAVDLSCAFVLCDITQNDHPIIYVSEAFERLTGYTEQEIVGQNCRFLQGPEGVVQKGMKRTFVDDETTSRLRSTIEDRTEIQASLINYRKGGQPFMNLITMIPIRWSSQEYRFYVGFQVDLVETPDAVTRRNPNGTYTINYQRSRLPNYVVPPPDLYRSHPDLTTWFTTDQVSTILKSLNNSTLTYRNYLDRVLVENTDDIIHALSLEGEFLYLSPSCRKVLEYEPIELVGKTLSTVCHPSDIGPVIRDLRACTTTDPVSVVFRIRKKYSGYIWFESHGSWRMGERGRQFMVLVGRPRFVYCLDHIASIGHGSLAETDVWAKLSKSGIVLFMTSKARPVLGRMPDELIGKSLQDLMDSRAEAQKALGVARTGQRVTFSHKIRHKKGHMLPAQTTLHPGDTKEGVRPSFLVAHISFPKPPQGGNDELNSAPPPNRNLAVSKIHRQAVSGVSGVAGQNMLASVKQANPQIQKLPFFTELVPTRGSSWQVELRELEKQNRTLSDELQKLLTRRKKRKRKQSTASVEKSCAICQTKKTPEWRRGPSGERDLCNSCGLRWAKQVRNAAQVAGRPNAY" }, { "InterPro": [ { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 32, "End": 109 }, { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 32, "End": 106 } ], "response#1": "MFSRVIFCTFLILPLLAAATAIPRTNPPAPTCTTGSLQCCNSVQAASNPVVGLLAGLLGIVLGPITGQVGLTCSPITVIGVGGTSCSAQTVCCNGNSFNGLIVVGCSPVNISL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Hydrophobin, Hydrophobin that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MFSRVIFCTFLILPLLAAATAIPRTNPPAPTCTTGSLQCCNSVQAASNPVVGLLAGLLGIVLGPITGQVGLTCSPITVIGVGGTSCSAQTVCCNGNSFNGLIVVGCSPVNISL" }, { "InterPro": [ { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 33, "End": 106 }, { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 33, "End": 109 } ], "response#1": "MFSIRIATVVLAASAALRPPARITNTETPVNQCGSGSIQCCESVQSASAAQAAGILGPLDILTNLQGLVGSHCSPLAAVGVSGTSCSSQTVCCKDVSKSGLVNLGCSPINLNL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Hydrophobin, Hydrophobin that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MFSIRIATVVLAASAALRPPARITNTETPVNQCGSGSIQCCESVQSASAAQAAGILGPLDILTNLQGLVGSHCSPLAAVGVSGTSCSSQTVCCKDVSKSGLVNLGCSPINLNL" }, { "InterPro": [ { "InterPro-ID": "IPR036686", "InterPro-Name": "Hydrophobin_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 22, "End": 98 }, { "InterPro-ID": "IPR036686", "InterPro-Name": "Hydrophobin_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 36, "End": 98 }, { "InterPro-ID": "IPR010636", "InterPro-Name": "Cerato-ulmin_hydrophobin", "InterPro-Type": "FAMILY", "Beg": 1, "End": 97 }, { "InterPro-ID": "IPR010636", "InterPro-Name": "Cerato-ulmin_hydrophobin", "InterPro-Type": "FAMILY", "Beg": 34, "End": 97 }, { "InterPro-ID": "IPR010636", "InterPro-Name": "Cerato-ulmin_hydrophobin", "InterPro-Type": "FAMILY", "Beg": 35, "End": 98 } ], "response#1": "MQFTTTTLIAILSALAVASPIEPRQNATAQQERLCTSAIDTAMCCQTTLAGVINQTCTTPAITPINKQAFRAYCAAQGQDSSCCKTPLVGDGVICTPP", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Cerato-ulmin_hydrophobin, Cerato-ulmin_hydrophobin, Cerato-ulmin_hydrophobin that shares evolutionary origin and functional similarity; 2. The protein should be classified within Hydrophobin_sf, Hydrophobin_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MQFTTTTLIAILSALAVASPIEPRQNATAQQERLCTSAIDTAMCCQTTLAGVINQTCTTPAITPINKQAFRAYCAAQGQDSSCCKTPLVGDGVICTPP" }, { "InterPro": [ { "InterPro-ID": "IPR010636", "InterPro-Name": "Cerato-ulmin_hydrophobin", "InterPro-Type": "FAMILY", "Beg": 8, "End": 97 }, { "InterPro-ID": "IPR036686", "InterPro-Name": "Hydrophobin_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 37, "End": 95 }, { "InterPro-ID": "IPR010636", "InterPro-Name": "Cerato-ulmin_hydrophobin", "InterPro-Type": "FAMILY", "Beg": 33, "End": 92 }, { "InterPro-ID": "IPR010636", "InterPro-Name": "Cerato-ulmin_hydrophobin", "InterPro-Type": "FAMILY", "Beg": 34, "End": 95 }, { "InterPro-ID": "IPR036686", "InterPro-Name": "Hydrophobin_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 23, "End": 97 } ], "response#1": "MFFSRISTIVSMTALFASALAMPTTLTSRQDAICSSGNPQCCDVDVLGVADLDCEAPPAAYTDIKSFSDVCADVGKINMCCDLPVLGQGLICSSPDNS", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Cerato-ulmin_hydrophobin, Cerato-ulmin_hydrophobin, Cerato-ulmin_hydrophobin that shares evolutionary origin and functional similarity; 2. The protein should be classified within Hydrophobin_sf, Hydrophobin_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MFFSRISTIVSMTALFASALAMPTTLTSRQDAICSSGNPQCCDVDVLGVADLDCEAPPAAYTDIKSFSDVCADVGKINMCCDLPVLGQGLICSSPDNS" }, { "InterPro": [ { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 50, "End": 127 }, { "InterPro-ID": "IPR019778", "InterPro-Name": "Hydrophobin_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 101, "End": 112 }, { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 50, "End": 124 } ], "response#1": "MFFRTSSLFTTIVAFTVMAAAMPGNPKPTTTTVTVTAPAHPTATAPASECKTGPVQCCNSVQSSKSPAASLLLGLLGIVLQGVAVPVGLTCNPITVIGVGGNSCSAQTVCCENNNFSGLIAIGCTPINLSL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Hydrophobin, Hydrophobin that shares evolutionary origin and functional similarity; 2. The protein should contain Hydrophobin_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MFFRTSSLFTTIVAFTVMAAAMPGNPKPTTTTVTVTAPAHPTATAPASECKTGPVQCCNSVQSSKSPAASLLLGLLGIVLQGVAVPVGLTCNPITVIGVGGNSCSAQTVCCENNNFSGLIAIGCTPINLSL" }, { "InterPro": [ { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 31, "End": 107 }, { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 31, "End": 110 } ], "response#1": "MFSIRISTVVLAASALLAVAIPMTNTETPQCNTGPIQCCNSVQSATSSAAAGPLAALGVLSGIASLLGEVGLDCSPLQVIGVGANSCSSQAACCTGNTFNGAVVLGCSPIKLL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Hydrophobin, Hydrophobin that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MFSIRISTVVLAASALLAVAIPMTNTETPQCNTGPIQCCNSVQSATSSAAAGPLAALGVLSGIASLLGEVGLDCSPLQVIGVGANSCSSQAACCTGNTFNGAVVLGCSPIKLL" }, { "InterPro": [ { "InterPro-ID": "IPR033119", "InterPro-Name": "GH11_AS_2", "InterPro-Type": "ACTIVE_SITE", "Beg": 204, "End": 215 }, { "InterPro-ID": "IPR000254", "InterPro-Name": "Cellulose-bd_dom_fun", "InterPro-Type": "DOMAIN", "Beg": 246, "End": 281 }, { "InterPro-ID": "IPR013319", "InterPro-Name": "GH11/12", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 32, "End": 225 }, { "InterPro-ID": "IPR000254", "InterPro-Name": "Cellulose-bd_dom_fun", "InterPro-Type": "DOMAIN", "Beg": 249, "End": 281 }, { "InterPro-ID": "IPR033123", "InterPro-Name": "GH11_dom", "InterPro-Type": "DOMAIN", "Beg": 32, "End": 220 }, { "InterPro-ID": "IPR001137", "InterPro-Name": "Glyco_hydro_11", "InterPro-Type": "FAMILY", "Beg": 1, "End": 220 }, { "InterPro-ID": "IPR000254", "InterPro-Name": "Cellulose-bd_dom_fun", "InterPro-Type": "DOMAIN", "Beg": 254, "End": 280 }, { "InterPro-ID": "IPR035971", "InterPro-Name": "CBD_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 250, "End": 281 }, { "InterPro-ID": "IPR000254", "InterPro-Name": "Cellulose-bd_dom_fun", "InterPro-Type": "DOMAIN", "Beg": 250, "End": 277 }, { "InterPro-ID": "IPR018208", "InterPro-Name": "GH11_AS_1", "InterPro-Type": "ACTIVE_SITE", "Beg": 113, "End": 123 }, { "InterPro-ID": "IPR013320", "InterPro-Name": "ConA-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 33, "End": 223 }, { "InterPro-ID": "IPR001137", "InterPro-Name": "Glyco_hydro_11", "InterPro-Type": "FAMILY", "Beg": 103, "End": 112 }, { "InterPro-ID": "IPR001137", "InterPro-Name": "Glyco_hydro_11", "InterPro-Type": "FAMILY", "Beg": 141, "End": 147 }, { "InterPro-ID": "IPR001137", "InterPro-Name": "Glyco_hydro_11", "InterPro-Type": "FAMILY", "Beg": 113, "End": 123 }, { "InterPro-ID": "IPR001137", "InterPro-Name": "Glyco_hydro_11", "InterPro-Type": "FAMILY", "Beg": 166, "End": 175 }, { "InterPro-ID": "IPR001137", "InterPro-Name": "Glyco_hydro_11", "InterPro-Type": "FAMILY", "Beg": 161, "End": 166 }, { "InterPro-ID": "IPR001137", "InterPro-Name": "Glyco_hydro_11", "InterPro-Type": "FAMILY", "Beg": 189, "End": 197 }, { "InterPro-ID": "IPR033123", "InterPro-Name": "GH11_dom", "InterPro-Type": "DOMAIN", "Beg": 42, "End": 218 } ], "response#1": "MVSYKAFLITLAAVTRVLTYPANSSFELVDRSGTPSSTGTSGGYYYSFWTDGGADVTYTNGAGGEYKLQWSGNGNLVGGKGWNPGSAKAVTYSGTYSPNGNSYLSLYGWTTSPLIEYYVVENFGTYDPSTGATLKGTVVSDGATYKIYQTQRVNQPSIIGTATFYQYWSVRQTKRTGGTVTTGNHFNAWKALGMNMGTFDYMIVATEGYFSSGSSDITVGSSTGGGDSGSPTSAPTTSPTTSPGGTCGALYSQCGGTGFTGSQCCASGTCKYANSYYSQCL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Cellulose-bd_dom_fun, Cellulose-bd_dom_fun, GH11_dom, Cellulose-bd_dom_fun, Cellulose-bd_dom_fun, GH11_dom that are essential for its biological function; 2. The protein should belong to Glyco_hydro_11, Glyco_hydro_11, Glyco_hydro_11, Glyco_hydro_11, Glyco_hydro_11, Glyco_hydro_11, Glyco_hydro_11 that shares evolutionary origin and functional similarity; 3. The protein should be classified within GH11/12, CBD_sf, ConA-like_dom_sf sharing conserved structural features; 4. The protein must have GH11_AS_2, GH11_AS_1 that is conserved among related catalytic enzymes. The designed protein sequence is ", "reference": "MVSYKAFLITLAAVTRVLTYPANSSFELVDRSGTPSSTGTSGGYYYSFWTDGGADVTYTNGAGGEYKLQWSGNGNLVGGKGWNPGSAKAVTYSGTYSPNGNSYLSLYGWTTSPLIEYYVVENFGTYDPSTGATLKGTVVSDGATYKIYQTQRVNQPSIIGTATFYQYWSVRQTKRTGGTVTTGNHFNAWKALGMNMGTFDYMIVATEGYFSSGSSDITVGSSTGGGDSGSPTSAPTTSPTTSPGGTCGALYSQCGGTGFTGSQCCASGTCKYANSYYSQCL" }, { "InterPro": [ { "InterPro-ID": "IPR013319", "InterPro-Name": "GH11/12", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 47, "End": 222 }, { "InterPro-ID": "IPR033123", "InterPro-Name": "GH11_dom", "InterPro-Type": "DOMAIN", "Beg": 36, "End": 222 }, { "InterPro-ID": "IPR033123", "InterPro-Name": "GH11_dom", "InterPro-Type": "DOMAIN", "Beg": 49, "End": 219 }, { "InterPro-ID": "IPR001137", "InterPro-Name": "Glyco_hydro_11", "InterPro-Type": "FAMILY", "Beg": 1, "End": 222 }, { "InterPro-ID": "IPR013320", "InterPro-Name": "ConA-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 49, "End": 221 }, { "InterPro-ID": "IPR001137", "InterPro-Name": "Glyco_hydro_11", "InterPro-Type": "FAMILY", "Beg": 143, "End": 149 }, { "InterPro-ID": "IPR001137", "InterPro-Name": "Glyco_hydro_11", "InterPro-Type": "FAMILY", "Beg": 191, "End": 199 }, { "InterPro-ID": "IPR001137", "InterPro-Name": "Glyco_hydro_11", "InterPro-Type": "FAMILY", "Beg": 107, "End": 116 }, { "InterPro-ID": "IPR001137", "InterPro-Name": "Glyco_hydro_11", "InterPro-Type": "FAMILY", "Beg": 117, "End": 127 }, { "InterPro-ID": "IPR001137", "InterPro-Name": "Glyco_hydro_11", "InterPro-Type": "FAMILY", "Beg": 163, "End": 168 }, { "InterPro-ID": "IPR001137", "InterPro-Name": "Glyco_hydro_11", "InterPro-Type": "FAMILY", "Beg": 168, "End": 177 } ], "response#1": "MITFSSLLVTFSAISTSLAIPGSILPKRSPMNFVLQRNESSLVRRATPNYEQDYTTGGDVIYTPSGSSFTVDWSTEDDFVVGLGWTTGSTNPINFSGTFGIGSGTALLSIYGWSENPLVEYYIVEDSASPPSFGTVKGSVTSDGSSYTIWENQRVNEPSIVGTATFNQYISVRSSPRKSGTVTVENHFQAWAALGMNLGTLNYQVLAVEGWGGEGAATQTVS", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more GH11_dom, GH11_dom that are essential for its biological function; 2. The protein should belong to Glyco_hydro_11, Glyco_hydro_11, Glyco_hydro_11, Glyco_hydro_11, Glyco_hydro_11, Glyco_hydro_11, Glyco_hydro_11 that shares evolutionary origin and functional similarity; 3. The protein should be classified within GH11/12, ConA-like_dom_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MITFSSLLVTFSAISTSLAIPGSILPKRSPMNFVLQRNESSLVRRATPNYEQDYTTGGDVIYTPSGSSFTVDWSTEDDFVVGLGWTTGSTNPINFSGTFGIGSGTALLSIYGWSENPLVEYYIVEDSASPPSFGTVKGSVTSDGSSYTIWENQRVNEPSIVGTATFNQYISVRSSPRKSGTVTVENHFQAWAALGMNLGTLNYQVLAVEGWGGEGAATQTVS" }, { "InterPro": [ { "InterPro-ID": "IPR002919", "InterPro-Name": "TIL_dom", "InterPro-Type": "DOMAIN", "Beg": 26, "End": 82 }, { "InterPro-ID": "IPR036084", "InterPro-Name": "Ser_inhib-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 24, "End": 83 } ], "response#1": "MKTLCIFLVLVVAVAAFPPFISQHDCPPNKEFGSYGDCPPSCLKNPPNFCTLKLNYGCKCKEGYVLTRYQDYESDCIKPEECPDDS", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more TIL_dom that are essential for its biological function; 2. The protein should be classified within Ser_inhib-like_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MKTLCIFLVLVVAVAAFPPFISQHDCPPNKEFGSYGDCPPSCLKNPPNFCTLKLNYGCKCKEGYVLTRYQDYESDCIKPEECPDDS" }, { "InterPro": [ { "InterPro-ID": "IPR010636", "InterPro-Name": "Cerato-ulmin_hydrophobin", "InterPro-Type": "FAMILY", "Beg": 4, "End": 96 }, { "InterPro-ID": "IPR010636", "InterPro-Name": "Cerato-ulmin_hydrophobin", "InterPro-Type": "FAMILY", "Beg": 31, "End": 95 }, { "InterPro-ID": "IPR036686", "InterPro-Name": "Hydrophobin_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 31, "End": 97 }, { "InterPro-ID": "IPR010636", "InterPro-Name": "Cerato-ulmin_hydrophobin", "InterPro-Type": "FAMILY", "Beg": 30, "End": 92 }, { "InterPro-ID": "IPR036686", "InterPro-Name": "Hydrophobin_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 18, "End": 98 } ], "response#1": "MKFIAVVAALTASLAMAAPTESSTDTTYIACPISLYGNAQCCATDILGLANLDCESPTDVPRDAGHFQRTCADVGKRARCCAIPVLGQALLCIQPAGAN", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Cerato-ulmin_hydrophobin, Cerato-ulmin_hydrophobin, Cerato-ulmin_hydrophobin that shares evolutionary origin and functional similarity; 2. The protein should be classified within Hydrophobin_sf, Hydrophobin_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MKFIAVVAALTASLAMAAPTESSTDTTYIACPISLYGNAQCCATDILGLANLDCESPTDVPRDAGHFQRTCADVGKRARCCAIPVLGQALLCIQPAGAN" }, { "InterPro": [ { "InterPro-ID": "IPR001138", "InterPro-Name": "Zn2Cys6_DnaBD", "InterPro-Type": "DOMAIN", "Beg": 55, "End": 90 }, { "InterPro-ID": "IPR001138", "InterPro-Name": "Zn2Cys6_DnaBD", "InterPro-Type": "DOMAIN", "Beg": 54, "End": 98 }, { "InterPro-ID": "IPR001138", "InterPro-Name": "Zn2Cys6_DnaBD", "InterPro-Type": "DOMAIN", "Beg": 58, "End": 93 }, { "InterPro-ID": "IPR001138", "InterPro-Name": "Zn2Cys6_DnaBD", "InterPro-Type": "DOMAIN", "Beg": 59, "End": 87 }, { "InterPro-ID": "IPR036864", "InterPro-Name": "Zn2-C6_fun-type_DNA-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 52, "End": 111 }, { "InterPro-ID": "IPR001138", "InterPro-Name": "Zn2Cys6_DnaBD", "InterPro-Type": "DOMAIN", "Beg": 59, "End": 89 }, { "InterPro-ID": "IPR036864", "InterPro-Name": "Zn2-C6_fun-type_DNA-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 50, "End": 98 } ], "response#1": "MSYPSQGHYLPPEHQYLTAATLASHGHEHLYAHSQLSDSPPRQDLAQRKRPKYTRSKTGCLTCRMKKIKCDETKPTCARCTHGQRECTWPDASSPRRRAPLRRGSIDDRPSTAGSSVSDDSSPSIRNSTPPRRFQMDSPESGLLPPPSARRNMDPFLQLPPVVAPESRHQHIRPRPPPFTPPQSEQHNLTLSPDPSEYCRYDRYDATYAQTHHLHSSHSSPSSRAPHMVTGIRGMGYSPESVHQWNSPPLLSPIESSSYQHYPLQERGMVGPSDNHHFRYQ", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Zn2Cys6_DnaBD, Zn2Cys6_DnaBD, Zn2Cys6_DnaBD, Zn2Cys6_DnaBD, Zn2Cys6_DnaBD that are essential for its biological function; 2. The protein should be classified within Zn2-C6_fun-type_DNA-bd_sf, Zn2-C6_fun-type_DNA-bd_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MSYPSQGHYLPPEHQYLTAATLASHGHEHLYAHSQLSDSPPRQDLAQRKRPKYTRSKTGCLTCRMKKIKCDETKPTCARCTHGQRECTWPDASSPRRRAPLRRGSIDDRPSTAGSSVSDDSSPSIRNSTPPRRFQMDSPESGLLPPPSARRNMDPFLQLPPVVAPESRHQHIRPRPPPFTPPQSEQHNLTLSPDPSEYCRYDRYDATYAQTHHLHSSHSSPSSRAPHMVTGIRGMGYSPESVHQWNSPPLLSPIESSSYQHYPLQERGMVGPSDNHHFRYQ" }, { "InterPro": [ { "InterPro-ID": "IPR001137", "InterPro-Name": "Glyco_hydro_11", "InterPro-Type": "FAMILY", "Beg": 185, "End": 193 }, { "InterPro-ID": "IPR001137", "InterPro-Name": "Glyco_hydro_11", "InterPro-Type": "FAMILY", "Beg": 137, "End": 143 }, { "InterPro-ID": "IPR001137", "InterPro-Name": "Glyco_hydro_11", "InterPro-Type": "FAMILY", "Beg": 157, "End": 162 }, { "InterPro-ID": "IPR001137", "InterPro-Name": "Glyco_hydro_11", "InterPro-Type": "FAMILY", "Beg": 99, "End": 108 }, { "InterPro-ID": "IPR001137", "InterPro-Name": "Glyco_hydro_11", "InterPro-Type": "FAMILY", "Beg": 109, "End": 119 }, { "InterPro-ID": "IPR001137", "InterPro-Name": "Glyco_hydro_11", "InterPro-Type": "FAMILY", "Beg": 162, "End": 171 }, { "InterPro-ID": "IPR033123", "InterPro-Name": "GH11_dom", "InterPro-Type": "DOMAIN", "Beg": 28, "End": 216 }, { "InterPro-ID": "IPR001137", "InterPro-Name": "Glyco_hydro_11", "InterPro-Type": "FAMILY", "Beg": 1, "End": 216 }, { "InterPro-ID": "IPR013319", "InterPro-Name": "GH11/12", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 24, "End": 216 }, { "InterPro-ID": "IPR033119", "InterPro-Name": "GH11_AS_2", "InterPro-Type": "ACTIVE_SITE", "Beg": 200, "End": 211 }, { "InterPro-ID": "IPR018208", "InterPro-Name": "GH11_AS_1", "InterPro-Type": "ACTIVE_SITE", "Beg": 109, "End": 119 }, { "InterPro-ID": "IPR013320", "InterPro-Name": "ConA-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 27, "End": 216 }, { "InterPro-ID": "IPR033123", "InterPro-Name": "GH11_dom", "InterPro-Type": "DOMAIN", "Beg": 38, "End": 214 } ], "response#1": "MVSFSSLFVAACAAVTAFALPSELEKRAITTSQQGTSNGYFYSFWTNGGGSVSYNNGASGEYSVSWSNCGSFTSGKGWATGSSRNINFSGSFKPSGNAYLAVYGWTTSPLVEYYIMENYGDYNPGRSMTFKGTVTSDGSVYDIYTHQQVNQPSISGTATFEQYWSIRRTKRSSGTVTTANHFKAWASHGMYLGSHNYQIVSTEGYQSSGSSDITVS", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more GH11_dom, GH11_dom that are essential for its biological function; 2. The protein should belong to Glyco_hydro_11, Glyco_hydro_11, Glyco_hydro_11, Glyco_hydro_11, Glyco_hydro_11, Glyco_hydro_11, Glyco_hydro_11 that shares evolutionary origin and functional similarity; 3. The protein should be classified within GH11/12, ConA-like_dom_sf sharing conserved structural features; 4. The protein must have GH11_AS_2, GH11_AS_1 that is conserved among related catalytic enzymes. The designed protein sequence is ", "reference": "MVSFSSLFVAACAAVTAFALPSELEKRAITTSQQGTSNGYFYSFWTNGGGSVSYNNGASGEYSVSWSNCGSFTSGKGWATGSSRNINFSGSFKPSGNAYLAVYGWTTSPLVEYYIMENYGDYNPGRSMTFKGTVTSDGSVYDIYTHQQVNQPSISGTATFEQYWSIRRTKRSSGTVTTANHFKAWASHGMYLGSHNYQIVSTEGYQSSGSSDITVS" }, { "InterPro": [ { "InterPro-ID": "IPR016024", "InterPro-Name": "ARM-type_fold", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 6, "End": 1106 }, { "InterPro-ID": "IPR045206", "InterPro-Name": "Maestro_heat-like_prot", "InterPro-Type": "FAMILY", "Beg": 85, "End": 1766 }, { "InterPro-ID": "IPR055408", "InterPro-Name": "HEAT_MROH2B-like", "InterPro-Type": "DOMAIN", "Beg": 285, "End": 933 }, { "InterPro-ID": "IPR055406", "InterPro-Name": "HEAT_Maestro", "InterPro-Type": "DOMAIN", "Beg": 1503, "End": 1725 }, { "InterPro-ID": "IPR011989", "InterPro-Name": "ARM-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1133, "End": 1292 }, { "InterPro-ID": "IPR011989", "InterPro-Name": "ARM-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 2, "End": 769 }, { "InterPro-ID": "IPR048465", "InterPro-Name": "Maestro-like_HEAT", "InterPro-Type": "DOMAIN", "Beg": 1045, "End": 1282 }, { "InterPro-ID": "IPR016024", "InterPro-Name": "ARM-type_fold", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1151, "End": 1764 }, { "InterPro-ID": "IPR011989", "InterPro-Name": "ARM-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1386, "End": 1767 } ], "response#1": "MAATSQVSSLLDLIMSLLDTATTYQHQESVKNEVAESLKTIGSHQPNVLLTACHQYLLQNPKLGAFKRAFVLQTISICVDNCEVVSKLDEQIIMLIINLATQEMNMTKDTDVEWAESSMEVLVTLAKNTRFVSHVIDAILQKFPPGQTTSPHRYIVLTMATIAVHNPFGLVPFLTDILSRTVPLLQHVKTDPLRCAWARAICSFCEAVRECETERPKEASEEYIGDHSRPNSASGHCQEVSNRATYSDQTEAVYDVIFSWIYSKDPKTRGEAAECVGELCLMIKQTRLVEDVKKIVTNMIPLYRKSYNESHMITQGICRFLEAACVDETCPLEPYLEDILNALFPNACLDPDDTTVTLSTQAIKNHSEAFRCFDVAATRFADRIVYYLLHKMQNVADSQKLGAINVLRHLLNATGQHMEDKRSLLTMGLKKLLAAENTTSIRVKRAIVQLCVALADHSYVDAEGGDYVIAFLVRNLVGPTEQESAAKKVEVDVAGLNQLRTQCAQALYTIANTCVCATKLLWPYLLEFICCERYTPVVGDLCKCLRTLVSREVEAGRKMDYVTGFDNPKVAGRHAVFARLFTSFCNAPLNGLLTRRAREAGGLIQAVAPWFHPSMEGPAARWSEKLEPLLDELSTTVSSGDSAPAELRGRKIARWHEACLDWLSACVAVVPEGDWRQDLAAAMGKQLDMYKELSDEKSFLLRCLGVTLARITAKQFVIDHMMLMFKSASHSVLTERQGCARGVGSIATSHMDLILIELENVSKWEHARKSSGIFGFIKDTMPIRQYPDIEMIHLRATLMLCYGHVVMACSLDTITQRLQNTIIVFLRNYFANSKQETVVREAMLETMRLIATAVHPSRIGGEWKFEARNELLAYAKDYLNGETPEWLTSSLRLLACKTTAALVQLEPPLSPADIEDIGTVLTRQILPMQREKSGLKTLAFDIFDYASSSVFSTFSGSSSSHTNIYMTPPLTANSVAEGPNGTPIHQRHRGIGGKMEDDESATIMDATMHQYGLALEQIVRMAPTTQTIMILLKILLPYYGKQADHERIRAVDMTVLVLRVYYECAEDISLGHASDFEPLSSLLGRLAPRLIDLLAHVRLQALSAIHWTLRLAYMHKGHGRDADQSLFSYSGFVEKYLTSGDVKLEGQKEKLAIEAIAQIIEYRLPQSQMQIYLSAIFEMLTDRQSHVSSAAAQLLTYAVMARGATLNAEAEILVTKMVEKLADIHHCVQTNTDVLAALVAFAVHQQQAVCDVLFKQPLPYSINITDAWECLSRDKLLFAVILDHLTELLGASLDQPFELMDSGGGVSAKVVNVEPCTYVAVLAEVVKNGEPESALMERLPLILTLLIHFICSVSDTQFPVMQKEGSKNPLIITPDLRRAAEKPAGMAVAAIKNLLNRTRSNMVIEDMNQARAWTDCLDKDSFIQAITVFIRSLVEQRPAWVSPLAKTMEEYANSESEPRRLAAVIIAASLIRRSTSENGEFNEQLLVKCIRRLEDSLTDPSLRIRKLCVKGLGELSECSSTDVISRFVHMAVEAAMSGLDDHGDRKDTVAIESIMALNKLVQLTNNDQLKSILPLVLLKIRPCFEKDSHTLRAASFSLFGELGSRVGENSEEFRGHLHTNIVSLLLHLNDDFEEVRQNCANSIYRLHGLLTSPNASICIERELKDGKQPASYNLFIKDFASILANSFPDRINQYALATSNYFKSSSARIRCNAAHLTGCLLDGLTAPLRATISRELVFTGLVALLKDSEDVNVRISATRAIANLHDFH", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more HEAT_MROH2B-like, HEAT_Maestro, Maestro-like_HEAT that are essential for its biological function; 2. The protein should belong to Maestro_heat-like_prot that shares evolutionary origin and functional similarity; 3. The protein should be classified within ARM-type_fold, ARM-like, ARM-like, ARM-type_fold, ARM-like sharing conserved structural features. The designed protein sequence is ", "reference": "MAATSQVSSLLDLIMSLLDTATTYQHQESVKNEVAESLKTIGSHQPNVLLTACHQYLLQNPKLGAFKRAFVLQTISICVDNCEVVSKLDEQIIMLIINLATQEMNMTKDTDVEWAESSMEVLVTLAKNTRFVSHVIDAILQKFPPGQTTSPHRYIVLTMATIAVHNPFGLVPFLTDILSRTVPLLQHVKTDPLRCAWARAICSFCEAVRECETERPKEASEEYIGDHSRPNSASGHCQEVSNRATYSDQTEAVYDVIFSWIYSKDPKTRGEAAECVGELCLMIKQTRLVEDVKKIVTNMIPLYRKSYNESHMITQGICRFLEAACVDETCPLEPYLEDILNALFPNACLDPDDTTVTLSTQAIKNHSEAFRCFDVAATRFADRIVYYLLHKMQNVADSQKLGAINVLRHLLNATGQHMEDKRSLLTMGLKKLLAAENTTSIRVKRAIVQLCVALADHSYVDAEGGDYVIAFLVRNLVGPTEQESAAKKVEVDVAGLNQLRTQCAQALYTIANTCVCATKLLWPYLLEFICCERYTPVVGDLCKCLRTLVSREVEAGRKMDYVTGFDNPKVAGRHAVFARLFTSFCNAPLNGLLTRRAREAGGLIQAVAPWFHPSMEGPAARWSEKLEPLLDELSTTVSSGDSAPAELRGRKIARWHEACLDWLSACVAVVPEGDWRQDLAAAMGKQLDMYKELSDEKSFLLRCLGVTLARITAKQFVIDHMMLMFKSASHSVLTERQGCARGVGSIATSHMDLILIELENVSKWEHARKSSGIFGFIKDTMPIRQYPDIEMIHLRATLMLCYGHVVMACSLDTITQRLQNTIIVFLRNYFANSKQETVVREAMLETMRLIATAVHPSRIGGEWKFEARNELLAYAKDYLNGETPEWLTSSLRLLACKTTAALVQLEPPLSPADIEDIGTVLTRQILPMQREKSGLKTLAFDIFDYASSSVFSTFSGSSSSHTNIYMTPPLTANSVAEGPNGTPIHQRHRGIGGKMEDDESATIMDATMHQYGLALEQIVRMAPTTQTIMILLKILLPYYGKQADHERIRAVDMTVLVLRVYYECAEDISLGHASDFEPLSSLLGRLAPRLIDLLAHVRLQALSAIHWTLRLAYMHKGHGRDADQSLFSYSGFVEKYLTSGDVKLEGQKEKLAIEAIAQIIEYRLPQSQMQIYLSAIFEMLTDRQSHVSSAAAQLLTYAVMARGATLNAEAEILVTKMVEKLADIHHCVQTNTDVLAALVAFAVHQQQAVCDVLFKQPLPYSINITDAWECLSRDKLLFAVILDHLTELLGASLDQPFELMDSGGGVSAKVVNVEPCTYVAVLAEVVKNGEPESALMERLPLILTLLIHFICSVSDTQFPVMQKEGSKNPLIITPDLRRAAEKPAGMAVAAIKNLLNRTRSNMVIEDMNQARAWTDCLDKDSFIQAITVFIRSLVEQRPAWVSPLAKTMEEYANSESEPRRLAAVIIAASLIRRSTSENGEFNEQLLVKCIRRLEDSLTDPSLRIRKLCVKGLGELSECSSTDVISRFVHMAVEAAMSGLDDHGDRKDTVAIESIMALNKLVQLTNNDQLKSILPLVLLKIRPCFEKDSHTLRAASFSLFGELGSRVGENSEEFRGHLHTNIVSLLLHLNDDFEEVRQNCANSIYRLHGLLTSPNASICIERELKDGKQPASYNLFIKDFASILANSFPDRINQYALATSNYFKSSSARIRCNAAHLTGCLLDGLTAPLRATISRELVFTGLVALLKDSEDVNVRISATRAIANLHDFH" }, { "InterPro": [ { "InterPro-ID": "IPR002919", "InterPro-Name": "TIL_dom", "InterPro-Type": "DOMAIN", "Beg": 23, "End": 75 }, { "InterPro-ID": "IPR036084", "InterPro-Name": "Ser_inhib-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 21, "End": 75 }, { "InterPro-ID": "IPR051368", "InterPro-Name": "SerProtInhib-TIL_Domain", "InterPro-Type": "FAMILY", "Beg": 21, "End": 75 } ], "response#1": "MSRILFVFLAVMAIFSTSFGQQCGLNEEFKSCGSCEPTCAKPRVTICTMECKIGCQCKSGYLRNGEGTCVLPEKC", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more TIL_dom that are essential for its biological function; 2. The protein should belong to SerProtInhib-TIL_Domain that shares evolutionary origin and functional similarity; 3. The protein should be classified within Ser_inhib-like_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MSRILFVFLAVMAIFSTSFGQQCGLNEEFKSCGSCEPTCAKPRVTICTMECKIGCQCKSGYLRNGEGTCVLPEKC" }, { "InterPro": [ { "InterPro-ID": "IPR010489", "InterPro-Name": "Effector_NleG", "InterPro-Type": "FAMILY", "Beg": 87, "End": 192 }, { "InterPro-ID": "IPR038436", "InterPro-Name": "Effector_NleG_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 93, "End": 194 } ], "response#1": "MQPVGLSNTPASSLLNETAELRHQTTPRQLGGIRIVGEIVDISYEPNDVVFFGVGRGVMIGDILFPGSSADIMRELLMAHSGVRGILQQQENAPSSLQTRISECTFSVSQEKLQCPEEEMRCPVTLETPEKGVFVKNSGDSSVCTLFDSSSFSRLVRDGGVHPLTREPIKASMIVSSDKCVYDNAKGNFVIKNS", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Effector_NleG that shares evolutionary origin and functional similarity; 2. The protein should be classified within Effector_NleG_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MQPVGLSNTPASSLLNETAELRHQTTPRQLGGIRIVGEIVDISYEPNDVVFFGVGRGVMIGDILFPGSSADIMRELLMAHSGVRGILQQQENAPSSLQTRISECTFSVSQEKLQCPEEEMRCPVTLETPEKGVFVKNSGDSSVCTLFDSSSFSRLVRDGGVHPLTREPIKASMIVSSDKCVYDNAKGNFVIKNS" }, { "InterPro": [ { "InterPro-ID": "IPR038436", "InterPro-Name": "Effector_NleG_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 107, "End": 208 }, { "InterPro-ID": "IPR010489", "InterPro-Name": "Effector_NleG", "InterPro-Type": "FAMILY", "Beg": 94, "End": 205 } ], "response#1": "MPIFLNFSAGSILPENELNSLRYIVQQNQNDTVIIRGRHQMEIRYIESVNGFTIHPVHSNHLSILMKRGNSLARNLERQINNGRSFEQVSRDFMLQLSLNIGWQKGAENALKSKIHSHAFIVNPDEFTCSKQYLECPITFCIPENGVFVKNSMDSKVCSLYDKSAIMQLIRKHHPHPLSREKIAKEMIIDKNNCYFDIMNQHFRILDTD", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Effector_NleG that shares evolutionary origin and functional similarity; 2. The protein should be classified within Effector_NleG_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MPIFLNFSAGSILPENELNSLRYIVQQNQNDTVIIRGRHQMEIRYIESVNGFTIHPVHSNHLSILMKRGNSLARNLERQINNGRSFEQVSRDFMLQLSLNIGWQKGAENALKSKIHSHAFIVNPDEFTCSKQYLECPITFCIPENGVFVKNSMDSKVCSLYDKSAIMQLIRKHHPHPLSREKIAKEMIIDKNNCYFDIMNQHFRILDTD" }, { "InterPro": [ { "InterPro-ID": "IPR036686", "InterPro-Name": "Hydrophobin_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 23, "End": 97 }, { "InterPro-ID": "IPR010636", "InterPro-Name": "Cerato-ulmin_hydrophobin", "InterPro-Type": "FAMILY", "Beg": 5, "End": 95 }, { "InterPro-ID": "IPR010636", "InterPro-Name": "Cerato-ulmin_hydrophobin", "InterPro-Type": "FAMILY", "Beg": 29, "End": 92 }, { "InterPro-ID": "IPR010636", "InterPro-Name": "Cerato-ulmin_hydrophobin", "InterPro-Type": "FAMILY", "Beg": 30, "End": 94 }, { "InterPro-ID": "IPR036686", "InterPro-Name": "Hydrophobin_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 29, "End": 97 } ], "response#1": "MKFFAIAALFAGALAMPTTEIEARTDKAVCPSGLYSNLVCADVDVLGILCLHATSPSETPRDARHFQEICAKVGKQARCAVLPVAEQAVLCQRPAGVSA", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Cerato-ulmin_hydrophobin, Cerato-ulmin_hydrophobin, Cerato-ulmin_hydrophobin that shares evolutionary origin and functional similarity; 2. The protein should be classified within Hydrophobin_sf, Hydrophobin_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MKFFAIAALFAGALAMPTTEIEARTDKAVCPSGLYSNLVCADVDVLGILCLHATSPSETPRDARHFQEICAKVGKQARCAVLPVAEQAVLCQRPAGVSA" }, { "InterPro": [ { "InterPro-ID": "IPR036686", "InterPro-Name": "Hydrophobin_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 86, "End": 142 }, { "InterPro-ID": "IPR010636", "InterPro-Name": "Cerato-ulmin_hydrophobin", "InterPro-Type": "FAMILY", "Beg": 96, "End": 138 }, { "InterPro-ID": "IPR010636", "InterPro-Name": "Cerato-ulmin_hydrophobin", "InterPro-Type": "FAMILY", "Beg": 232, "End": 296 }, { "InterPro-ID": "IPR036686", "InterPro-Name": "Hydrophobin_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 231, "End": 299 }, { "InterPro-ID": "IPR010636", "InterPro-Name": "Cerato-ulmin_hydrophobin", "InterPro-Type": "FAMILY", "Beg": 234, "End": 296 }, { "InterPro-ID": "IPR010636", "InterPro-Name": "Cerato-ulmin_hydrophobin", "InterPro-Type": "FAMILY", "Beg": 232, "End": 294 }, { "InterPro-ID": "IPR010636", "InterPro-Name": "Cerato-ulmin_hydrophobin", "InterPro-Type": "FAMILY", "Beg": 95, "End": 138 }, { "InterPro-ID": "IPR036686", "InterPro-Name": "Hydrophobin_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 95, "End": 141 }, { "InterPro-ID": "IPR036686", "InterPro-Name": "Hydrophobin_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 226, "End": 299 } ], "response#1": "MKFLTVAAAIFASTSLAVPTNNHNGGGACVPRPNPGNSNTSSAPGGNPTGGHTSSGPGTKPTGSHTSSGPATKPTDGNTSSGPGTKPTDGNTSSGIDCEVPRHAPTSGDDFKGICAAVGKQPLCCVIPVAGQDLLCQDITGGNSPSGQPTSVPGGQSTSVPGGNPTSIPGGQPTSVPGGQPTSVPGGHPTSAPTGHPTSVPGGQPTSVPGGNPTSVPGHHNPSPVGNDPSCCPSGLYSNPQCCAANVLGLADLDCSTPSQTFTTGDEFRNICATIGRQPMCCVLPVAGQAVLCEKPVGV", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Cerato-ulmin_hydrophobin, Cerato-ulmin_hydrophobin, Cerato-ulmin_hydrophobin, Cerato-ulmin_hydrophobin, Cerato-ulmin_hydrophobin that shares evolutionary origin and functional similarity; 2. The protein should be classified within Hydrophobin_sf, Hydrophobin_sf, Hydrophobin_sf, Hydrophobin_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MKFLTVAAAIFASTSLAVPTNNHNGGGACVPRPNPGNSNTSSAPGGNPTGGHTSSGPGTKPTGSHTSSGPATKPTDGNTSSGPGTKPTDGNTSSGIDCEVPRHAPTSGDDFKGICAAVGKQPLCCVIPVAGQDLLCQDITGGNSPSGQPTSVPGGQSTSVPGGNPTSIPGGQPTSVPGGQPTSVPGGHPTSAPTGHPTSVPGGQPTSVPGGNPTSVPGHHNPSPVGNDPSCCPSGLYSNPQCCAANVLGLADLDCSTPSQTFTTGDEFRNICATIGRQPMCCVLPVAGQAVLCEKPVGV" }, { "InterPro": [ { "InterPro-ID": "IPR010636", "InterPro-Name": "Cerato-ulmin_hydrophobin", "InterPro-Type": "FAMILY", "Beg": 29, "End": 91 }, { "InterPro-ID": "IPR010636", "InterPro-Name": "Cerato-ulmin_hydrophobin", "InterPro-Type": "FAMILY", "Beg": 30, "End": 94 }, { "InterPro-ID": "IPR036686", "InterPro-Name": "Hydrophobin_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 29, "End": 96 }, { "InterPro-ID": "IPR036686", "InterPro-Name": "Hydrophobin_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 24, "End": 97 }, { "InterPro-ID": "IPR010636", "InterPro-Name": "Cerato-ulmin_hydrophobin", "InterPro-Type": "FAMILY", "Beg": 4, "End": 94 } ], "response#1": "MKSVVFASLIASALAVPTELAPRTDVSSLCPAGLYSVPQCCATDILGVARLDCKAPKQTPRNADEFKNICAKGGQQAACCVVPVAGQSLFCMTPVGI", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Cerato-ulmin_hydrophobin, Cerato-ulmin_hydrophobin, Cerato-ulmin_hydrophobin that shares evolutionary origin and functional similarity; 2. The protein should be classified within Hydrophobin_sf, Hydrophobin_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MKSVVFASLIASALAVPTELAPRTDVSSLCPAGLYSVPQCCATDILGVARLDCKAPKQTPRNADEFKNICAKGGQQAACCVVPVAGQSLFCMTPVGI" }, { "InterPro": [ { "InterPro-ID": "IPR000010", "InterPro-Name": "Cystatin_dom", "InterPro-Type": "DOMAIN", "Beg": 21, "End": 131 }, { "InterPro-ID": "IPR000010", "InterPro-Name": "Cystatin_dom", "InterPro-Type": "DOMAIN", "Beg": 35, "End": 130 }, { "InterPro-ID": "IPR018073", "InterPro-Name": "Prot_inh_cystat_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 70, "End": 83 }, { "InterPro-ID": "IPR046350", "InterPro-Name": "Cystatin_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 32, "End": 130 }, { "InterPro-ID": "IPR000010", "InterPro-Name": "Cystatin_dom", "InterPro-Type": "DOMAIN", "Beg": 29, "End": 115 } ], "response#1": "MTASFALVLLLGGVAVCIATGVFGGYSEKANHQANPEYLNLAHYATSTWSAQQPGKTHFDTVVEVLKVETQTVAGTNYRLTLKVAESTCELTSTYNKDTCLPKADVAQRTCTTVVCESLRGDKFVSSFECAAA", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Cystatin_dom, Cystatin_dom, Cystatin_dom that are essential for its biological function; 2. The protein should be classified within Cystatin_sf sharing conserved structural features; 3. The protein should contain Prot_inh_cystat_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MTASFALVLLLGGVAVCIATGVFGGYSEKANHQANPEYLNLAHYATSTWSAQQPGKTHFDTVVEVLKVETQTVAGTNYRLTLKVAESTCELTSTYNKDTCLPKADVAQRTCTTVVCESLRGDKFVSSFECAAA" }, { "InterPro": [ { "InterPro-ID": "IPR019775", "InterPro-Name": "WD40_repeat_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 208, "End": 222 }, { "InterPro-ID": "IPR001680", "InterPro-Name": "WD40_rpt", "InterPro-Type": "REPEAT", "Beg": 280, "End": 315 }, { "InterPro-ID": "IPR015943", "InterPro-Name": "WD40/YVTN_repeat-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 9, "End": 315 }, { "InterPro-ID": "IPR019775", "InterPro-Name": "WD40_repeat_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 79, "End": 93 }, { "InterPro-ID": "IPR001680", "InterPro-Name": "WD40_rpt", "InterPro-Type": "REPEAT", "Beg": 60, "End": 101 }, { "InterPro-ID": "IPR036322", "InterPro-Name": "WD40_repeat_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 7, "End": 311 }, { "InterPro-ID": "IPR001680", "InterPro-Name": "WD40_rpt", "InterPro-Type": "REPEAT", "Beg": 8, "End": 44 }, { "InterPro-ID": "IPR001680", "InterPro-Name": "WD40_rpt", "InterPro-Type": "REPEAT", "Beg": 187, "End": 221 }, { "InterPro-ID": "IPR001680", "InterPro-Name": "WD40_rpt", "InterPro-Type": "REPEAT", "Beg": 146, "End": 178 }, { "InterPro-ID": "IPR001680", "InterPro-Name": "WD40_rpt", "InterPro-Type": "REPEAT", "Beg": 289, "End": 311 }, { "InterPro-ID": "IPR001680", "InterPro-Name": "WD40_rpt", "InterPro-Type": "REPEAT", "Beg": 99, "End": 134 }, { "InterPro-ID": "IPR001680", "InterPro-Name": "WD40_rpt", "InterPro-Type": "REPEAT", "Beg": 55, "End": 92 }, { "InterPro-ID": "IPR001680", "InterPro-Name": "WD40_rpt", "InterPro-Type": "REPEAT", "Beg": 226, "End": 261 }, { "InterPro-ID": "IPR020472", "InterPro-Name": "G-protein_beta_WD-40_rep", "InterPro-Type": "REPEAT", "Beg": 208, "End": 222 }, { "InterPro-ID": "IPR020472", "InterPro-Name": "G-protein_beta_WD-40_rep", "InterPro-Type": "REPEAT", "Beg": 79, "End": 93 }, { "InterPro-ID": "IPR020472", "InterPro-Name": "G-protein_beta_WD-40_rep", "InterPro-Type": "REPEAT", "Beg": 121, "End": 135 }, { "InterPro-ID": "IPR019775", "InterPro-Name": "WD40_repeat_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 166, "End": 180 }, { "InterPro-ID": "IPR001680", "InterPro-Name": "WD40_rpt", "InterPro-Type": "REPEAT", "Beg": 145, "End": 188 }, { "InterPro-ID": "IPR001680", "InterPro-Name": "WD40_rpt", "InterPro-Type": "REPEAT", "Beg": 189, "End": 230 }, { "InterPro-ID": "IPR001680", "InterPro-Name": "WD40_rpt", "InterPro-Type": "REPEAT", "Beg": 182, "End": 221 }, { "InterPro-ID": "IPR001680", "InterPro-Name": "WD40_rpt", "InterPro-Type": "REPEAT", "Beg": 53, "End": 92 }, { "InterPro-ID": "IPR001680", "InterPro-Name": "WD40_rpt", "InterPro-Type": "REPEAT", "Beg": 224, "End": 261 }, { "InterPro-ID": "IPR001680", "InterPro-Name": "WD40_rpt", "InterPro-Type": "REPEAT", "Beg": 95, "End": 134 }, { "InterPro-ID": "IPR001680", "InterPro-Name": "WD40_rpt", "InterPro-Type": "REPEAT", "Beg": 264, "End": 312 }, { "InterPro-ID": "IPR001680", "InterPro-Name": "WD40_rpt", "InterPro-Type": "REPEAT", "Beg": 136, "End": 179 }, { "InterPro-ID": "IPR001680", "InterPro-Name": "WD40_rpt", "InterPro-Type": "REPEAT", "Beg": 5, "End": 45 }, { "InterPro-ID": "IPR001680", "InterPro-Name": "WD40_rpt", "InterPro-Type": "REPEAT", "Beg": 102, "End": 134 }, { "InterPro-ID": "IPR001680", "InterPro-Name": "WD40_rpt", "InterPro-Type": "REPEAT", "Beg": 12, "End": 54 }, { "InterPro-ID": "IPR045223", "InterPro-Name": "RACK1-like", "InterPro-Type": "FAMILY", "Beg": 3, "End": 313 } ], "response#1": "MASDQLRFLGSLEGHKGWVTAIATSQENPDMILTASRDKTIIVWQLTRDEDSYGYPKRILTGHNHFVSDVVISSDGQFALSSSWDHTLRLWDLNTGATTRRFVGHTSDVLSVSFSADNRQIVSGSRDKTIKLWNTLGECKYDIKDECHTEWVSCVRFSPNVSNPVIVSCGWDRVVKVWELSKFKLKTNHYGHTGYINTVSVSPDGSLAASGGKDGITMLWDLNEGKHLYSLEAGDIVNALVFSPNRYWLCAATASCVKIFDLESKSIVDELKPAYTDVQDEGRQPECVSIAWSADGQTLFAGFTDNQLRVWTVTS", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to RACK1-like that shares evolutionary origin and functional similarity; 2. The protein should be classified within WD40/YVTN_repeat-like_dom_sf, WD40_repeat_dom_sf sharing conserved structural features; 3. The protein should include one or more WD40_rpt, WD40_rpt, WD40_rpt, WD40_rpt, WD40_rpt, WD40_rpt, WD40_rpt, WD40_rpt, WD40_rpt, G-protein_beta_WD-40_rep, G-protein_beta_WD-40_rep, G-protein_beta_WD-40_rep, WD40_rpt, WD40_rpt, WD40_rpt, WD40_rpt, WD40_rpt, WD40_rpt, WD40_rpt, WD40_rpt, WD40_rpt, WD40_rpt, WD40_rpt that provide structural or functional support; 4. The protein should contain WD40_repeat_CS, WD40_repeat_CS, WD40_repeat_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MASDQLRFLGSLEGHKGWVTAIATSQENPDMILTASRDKTIIVWQLTRDEDSYGYPKRILTGHNHFVSDVVISSDGQFALSSSWDHTLRLWDLNTGATTRRFVGHTSDVLSVSFSADNRQIVSGSRDKTIKLWNTLGECKYDIKDECHTEWVSCVRFSPNVSNPVIVSCGWDRVVKVWELSKFKLKTNHYGHTGYINTVSVSPDGSLAASGGKDGITMLWDLNEGKHLYSLEAGDIVNALVFSPNRYWLCAATASCVKIFDLESKSIVDELKPAYTDVQDEGRQPECVSIAWSADGQTLFAGFTDNQLRVWTVTS" }, { "InterPro": [ { "InterPro-ID": "IPR036686", "InterPro-Name": "Hydrophobin_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 24, "End": 91 }, { "InterPro-ID": "IPR010636", "InterPro-Name": "Cerato-ulmin_hydrophobin", "InterPro-Type": "FAMILY", "Beg": 7, "End": 90 }, { "InterPro-ID": "IPR010636", "InterPro-Name": "Cerato-ulmin_hydrophobin", "InterPro-Type": "FAMILY", "Beg": 24, "End": 87 }, { "InterPro-ID": "IPR036686", "InterPro-Name": "Hydrophobin_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 23, "End": 93 }, { "InterPro-ID": "IPR010636", "InterPro-Name": "Cerato-ulmin_hydrophobin", "InterPro-Type": "FAMILY", "Beg": 24, "End": 89 } ], "response#1": "MKFFAVAALFVASAMAGPMGSEGCPGGLTGTVPLCCATNVLNIADLDCSTPTIPVPNVGIFQAHCASKGKQPVCCTLPVAGQGLLCNKPTGAQ", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Cerato-ulmin_hydrophobin, Cerato-ulmin_hydrophobin, Cerato-ulmin_hydrophobin that shares evolutionary origin and functional similarity; 2. The protein should be classified within Hydrophobin_sf, Hydrophobin_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MKFFAVAALFVASAMAGPMGSEGCPGGLTGTVPLCCATNVLNIADLDCSTPTIPVPNVGIFQAHCASKGKQPVCCTLPVAGQGLLCNKPTGAQ" }, { "InterPro": [ { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 39, "End": 113 }, { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 39, "End": 116 } ], "response#1": "MFARCVATIFASLLVTLAVASPEYYAPQGSTAPAPAGQCNVGNQQCCNTVQEASSDPVAGLLGLLGINVQDVTGLVGLTCNPITGIGGLNSGCDASPVCCENNSFGSLISIGCIPISL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Hydrophobin, Hydrophobin that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MFARCVATIFASLLVTLAVASPEYYAPQGSTAPAPAGQCNVGNQQCCNTVQEASSDPVAGLLGLLGINVQDVTGLVGLTCNPITGIGGLNSGCDASPVCCENNSFGSLISIGCIPISL" }, { "InterPro": [ { "InterPro-ID": "IPR028359", "InterPro-Name": "UDP_ManNAc/GlcNAc_DH", "InterPro-Type": "FAMILY", "Beg": 1, "End": 406 }, { "InterPro-ID": "IPR014027", "InterPro-Name": "UDP-Glc/GDP-Man_DH_C", "InterPro-Type": "DOMAIN", "Beg": 318, "End": 402 }, { "InterPro-ID": "IPR036291", "InterPro-Name": "NAD(P)-bd_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 6, "End": 200 }, { "InterPro-ID": "IPR017476", "InterPro-Name": "UDP-Glc/GDP-Man", "InterPro-Type": "FAMILY", "Beg": 5, "End": 406 }, { "InterPro-ID": "IPR014026", "InterPro-Name": "UDP-Glc/GDP-Man_DH_dimer", "InterPro-Type": "DOMAIN", "Beg": 208, "End": 295 }, { "InterPro-ID": "IPR028359", "InterPro-Name": "UDP_ManNAc/GlcNAc_DH", "InterPro-Type": "FAMILY", "Beg": 2, "End": 397 }, { "InterPro-ID": "IPR008927", "InterPro-Name": "6-PGluconate_DH-like_C_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 208, "End": 300 }, { "InterPro-ID": "IPR036220", "InterPro-Name": "UDP-Glc/GDP-Man_DH_C_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 304, "End": 400 }, { "InterPro-ID": "IPR001732", "InterPro-Name": "UDP-Glc/GDP-Man_DH_N", "InterPro-Type": "DOMAIN", "Beg": 6, "End": 189 }, { "InterPro-ID": "IPR017476", "InterPro-Name": "UDP-Glc/GDP-Man", "InterPro-Type": "FAMILY", "Beg": 6, "End": 402 } ], "response#1": "MNQFNKVCVIGLGYIGLPTAAIFASRKIKVIGVDINQNIVDIINKGKIHIVEPGLDILVHMVVNDGYLKATTLPEEADAFIIAVPTPFKGDNHEPNLDYIEMASKAIAKVLKKGNLVILESTSPVGTTEQMAKWLAEERSDLSFPHQCGEVSDIKIAHCPERVLPGQVIRELVENDRIIGGMTQKCAEYAIRLYKIFVQGECIMTNARTAEMTKLTENSFRDLNIAFANELSILCDKLDINVWELIKLANRHPRVNILQPGCGVGGHCIAVDPWFIVYQNPNEAKIIKTAREVNDNKPNFVVQKIKKKIKDILGPKIACLGLAFKPDIDDLRESPALDIVIKLASENASQILVVEPNIKQLPLKLQNKRNIKLVCLSQALDEADVVAVLVRHKEFIEVQSDKVVSFC", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more UDP-Glc/GDP-Man_DH_C, UDP-Glc/GDP-Man_DH_dimer, UDP-Glc/GDP-Man_DH_N that are essential for its biological function; 2. The protein should belong to UDP_ManNAc/GlcNAc_DH, UDP-Glc/GDP-Man, UDP_ManNAc/GlcNAc_DH, UDP-Glc/GDP-Man that shares evolutionary origin and functional similarity; 3. The protein should be classified within NAD(P)-bd_dom_sf, 6-PGluconate_DH-like_C_sf, UDP-Glc/GDP-Man_DH_C_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MNQFNKVCVIGLGYIGLPTAAIFASRKIKVIGVDINQNIVDIINKGKIHIVEPGLDILVHMVVNDGYLKATTLPEEADAFIIAVPTPFKGDNHEPNLDYIEMASKAIAKVLKKGNLVILESTSPVGTTEQMAKWLAEERSDLSFPHQCGEVSDIKIAHCPERVLPGQVIRELVENDRIIGGMTQKCAEYAIRLYKIFVQGECIMTNARTAEMTKLTENSFRDLNIAFANELSILCDKLDINVWELIKLANRHPRVNILQPGCGVGGHCIAVDPWFIVYQNPNEAKIIKTAREVNDNKPNFVVQKIKKKIKDILGPKIACLGLAFKPDIDDLRESPALDIVIKLASENASQILVVEPNIKQLPLKLQNKRNIKLVCLSQALDEADVVAVLVRHKEFIEVQSDKVVSFC" }, { "InterPro": [ { "InterPro-ID": "IPR013154", "InterPro-Name": "ADH-like_N", "InterPro-Type": "DOMAIN", "Beg": 36, "End": 153 }, { "InterPro-ID": "IPR047109", "InterPro-Name": "CAD-like", "InterPro-Type": "FAMILY", "Beg": 14, "End": 352 }, { "InterPro-ID": "IPR020843", "InterPro-Name": "PKS_ER", "InterPro-Type": "DOMAIN", "Beg": 23, "End": 351 }, { "InterPro-ID": "IPR036291", "InterPro-Name": "NAD(P)-bd_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 156, "End": 321 }, { "InterPro-ID": "IPR047109", "InterPro-Name": "CAD-like", "InterPro-Type": "FAMILY", "Beg": 8, "End": 356 }, { "InterPro-ID": "IPR002328", "InterPro-Name": "ADH_Zn_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 71, "End": 85 }, { "InterPro-ID": "IPR013149", "InterPro-Name": "ADH-like_C", "InterPro-Type": "DOMAIN", "Beg": 194, "End": 317 }, { "InterPro-ID": "IPR011032", "InterPro-Name": "GroES-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 19, "End": 185 } ], "response#1": "MAKSPEVEHPVKAFGWAARDPSGVLSPFNFSRRATGEHDVQFKVLYCGICHSDLHMIKNEWGFTKYPIVPGHEIVGVVTEVGSKVEKFKVGDKVGVGCLVGSCRKCDMCSDDLENYCPGQILTYSAAYTDGTTTYGGYSNLMVSDEHFVICWPENLPMDIGAPLLCAGITTYSPLRYFGLDKPGTHVGVVGLGGLGHVAVKFAKAFGAKVTVISTSESKKQEAIEKLGADAFLVSRDPEQMQGAAGSMDGIIDTVSAVHPVLPLVNLLKSQGKLIMVGAPEKPLELPVFPLLAGRRIIAGSAIGGLKETQEMIDFAAKNNILPDVELVPMDYVNTAMERLLKADVKYRFVIDIGNTLKSA", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more ADH-like_N, PKS_ER, ADH-like_C that are essential for its biological function; 2. The protein should belong to CAD-like, CAD-like that shares evolutionary origin and functional similarity; 3. The protein should be classified within NAD(P)-bd_dom_sf, GroES-like_sf sharing conserved structural features; 4. The protein should contain ADH_Zn_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MAKSPEVEHPVKAFGWAARDPSGVLSPFNFSRRATGEHDVQFKVLYCGICHSDLHMIKNEWGFTKYPIVPGHEIVGVVTEVGSKVEKFKVGDKVGVGCLVGSCRKCDMCSDDLENYCPGQILTYSAAYTDGTTTYGGYSNLMVSDEHFVICWPENLPMDIGAPLLCAGITTYSPLRYFGLDKPGTHVGVVGLGGLGHVAVKFAKAFGAKVTVISTSESKKQEAIEKLGADAFLVSRDPEQMQGAAGSMDGIIDTVSAVHPVLPLVNLLKSQGKLIMVGAPEKPLELPVFPLLAGRRIIAGSAIGGLKETQEMIDFAAKNNILPDVELVPMDYVNTAMERLLKADVKYRFVIDIGNTLKSA" }, { "InterPro": [ { "InterPro-ID": "IPR000731", "InterPro-Name": "SSD", "InterPro-Type": "DOMAIN", "Beg": 414, "End": 570 }, { "InterPro-ID": "IPR051697", "InterPro-Name": "Patched_domain-protein", "InterPro-Type": "FAMILY", "Beg": 136, "End": 1144 }, { "InterPro-ID": "IPR003392", "InterPro-Name": "PTHD_SSD", "InterPro-Type": "DOMAIN", "Beg": 421, "End": 568 } ], "response#1": "MEKNCNSVAGHAGTLVKASSRQADDKAGSRVPPGGHLLQTNKTESQLLPCASPSDPVHWTNEIVPVVADTSAPAEAAPDQTVSDGEQLTRAPDETYYQRSESLAEPPAENELPAGRSRRRRSRWCLGCGCFEQVKTVVLRMLMTGFEKYAGVVYDHPWLFIMVSLLATAGMSVGIFLRTPESDVYTLYSLSGSPSQVTKEHLLDVLPPDRLLFVLLTGTSNLVTRETVTRIDSLLQGIESITLRRDSVTTDEFNHRLVSHDRSPFPETITFQDICAKDGSGKCQVQSILDLYPSSSAWGVMPIASASWPVVTNPVTHKVSRLDAILGKITTSVRLAEQGSGRPALTVVEEAEAMLMRIDLRGETIWKPYTAAFEKLVLDYVLGQDFGPDISVTAKAERSSYDELKRVSTLDVVEWLRLCAAVLVVFLYTSVVNSSKTHRTKLVPSAMGALASLLGYLGGAGLVYLCGVRHTTPAEATPFLAIGIGVDDLFVIINAYSLTYLHPNPKERVVDAIRDAGLSITITTLTNVITFIIGALSPYYSISMFCIITAGALTWGYVLCLTFFLAGLSLDARREARKEPLSYSLFWRFMPRCCRKSSYEPQLSPPLPLTAAASGLEEMRNESEEIVTADQTPPTHGGDLLTTYQLAALMVLYKKHTCQSRSSQPARRLFDRRDGTGTEETMSTPVPEDSERDRTNQKSCGTQVSTGIVDVRETGQDAASQRRLSSHIRDMTTQESIMLLKNFEKEMEQNPEKLLKLYHPEPLGNPGRGSRRFFRDYYGRFLGNTFVKATVLVIFAAVTALAIYGATTLKFGLSLKNITPQASYLRDFYSLHEDLFPSYGDEVTVFFAENDRWEDREVQMRYLQMVKELSEQEWAVVVTDGMSLFLQHAMPSLHSGNRKEFLALLKTWLEGDPIGQNFSTFFKFSFDNLIVWQFRYWMPHRDNTTTLYYWLKEGKDIVSAGKPYFHGEVHTALAVIWESDPKILPFTLTNLSIALVCILAISLLLIPDLTSAIIVVLVVSLVDLWLFGFMALIDLPLSMISMVNLLISIGYSVDFTIHVAHTFTHCVGASRKDRMVETMIVMGAPVTHGMLSTLLSILALAGSPKYILEVFFKMMFMVIVFAYTAGMVLLPVVLTLLGPFHPHGKRESGKAIACDSSAQLIDMEPLHGTGKEEHGVGV", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more SSD, PTHD_SSD that are essential for its biological function; 2. The protein should belong to Patched_domain-protein that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MEKNCNSVAGHAGTLVKASSRQADDKAGSRVPPGGHLLQTNKTESQLLPCASPSDPVHWTNEIVPVVADTSAPAEAAPDQTVSDGEQLTRAPDETYYQRSESLAEPPAENELPAGRSRRRRSRWCLGCGCFEQVKTVVLRMLMTGFEKYAGVVYDHPWLFIMVSLLATAGMSVGIFLRTPESDVYTLYSLSGSPSQVTKEHLLDVLPPDRLLFVLLTGTSNLVTRETVTRIDSLLQGIESITLRRDSVTTDEFNHRLVSHDRSPFPETITFQDICAKDGSGKCQVQSILDLYPSSSAWGVMPIASASWPVVTNPVTHKVSRLDAILGKITTSVRLAEQGSGRPALTVVEEAEAMLMRIDLRGETIWKPYTAAFEKLVLDYVLGQDFGPDISVTAKAERSSYDELKRVSTLDVVEWLRLCAAVLVVFLYTSVVNSSKTHRTKLVPSAMGALASLLGYLGGAGLVYLCGVRHTTPAEATPFLAIGIGVDDLFVIINAYSLTYLHPNPKERVVDAIRDAGLSITITTLTNVITFIIGALSPYYSISMFCIITAGALTWGYVLCLTFFLAGLSLDARREARKEPLSYSLFWRFMPRCCRKSSYEPQLSPPLPLTAAASGLEEMRNESEEIVTADQTPPTHGGDLLTTYQLAALMVLYKKHTCQSRSSQPARRLFDRRDGTGTEETMSTPVPEDSERDRTNQKSCGTQVSTGIVDVRETGQDAASQRRLSSHIRDMTTQESIMLLKNFEKEMEQNPEKLLKLYHPEPLGNPGRGSRRFFRDYYGRFLGNTFVKATVLVIFAAVTALAIYGATTLKFGLSLKNITPQASYLRDFYSLHEDLFPSYGDEVTVFFAENDRWEDREVQMRYLQMVKELSEQEWAVVVTDGMSLFLQHAMPSLHSGNRKEFLALLKTWLEGDPIGQNFSTFFKFSFDNLIVWQFRYWMPHRDNTTTLYYWLKEGKDIVSAGKPYFHGEVHTALAVIWESDPKILPFTLTNLSIALVCILAISLLLIPDLTSAIIVVLVVSLVDLWLFGFMALIDLPLSMISMVNLLISIGYSVDFTIHVAHTFTHCVGASRKDRMVETMIVMGAPVTHGMLSTLLSILALAGSPKYILEVFFKMMFMVIVFAYTAGMVLLPVVLTLLGPFHPHGKRESGKAIACDSSAQLIDMEPLHGTGKEEHGVGV" }, { "InterPro": [ { "InterPro-ID": "IPR013087", "InterPro-Name": "Znf_C2H2_type", "InterPro-Type": "DOMAIN", "Beg": 438, "End": 465 }, { "InterPro-ID": "IPR013087", "InterPro-Name": "Znf_C2H2_type", "InterPro-Type": "DOMAIN", "Beg": 411, "End": 432 }, { "InterPro-ID": "IPR013087", "InterPro-Name": "Znf_C2H2_type", "InterPro-Type": "DOMAIN", "Beg": 440, "End": 460 }, { "InterPro-ID": "IPR013087", "InterPro-Name": "Znf_C2H2_type", "InterPro-Type": "DOMAIN", "Beg": 409, "End": 432 }, { "InterPro-ID": "IPR013087", "InterPro-Name": "Znf_C2H2_type", "InterPro-Type": "DOMAIN", "Beg": 438, "End": 460 }, { "InterPro-ID": "IPR013087", "InterPro-Name": "Znf_C2H2_type", "InterPro-Type": "DOMAIN", "Beg": 409, "End": 437 }, { "InterPro-ID": "IPR036236", "InterPro-Name": "Znf_C2H2_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 407, "End": 460 } ], "response#1": "MDSTMMPHTIRQNTIFGKTNFAQQKLGLYQVVAPASPVCSRPGSSCSQPPTLLGNNPGVLTPTGSLSPSSFKPAIMLETEFGDNPYYPSTPPLSTSGSAVGSPKSCDILQTPLNPMFSGLDGFSGVKSGFESIESSILSWTSCDSPPMTPVYIYSQPSRVPSLSSTTSDLSNIPCPSLSPSPAPYARSVSSENDVDFCDPRNLTVSCTSNPSLSDFTLDCLIEEDSSCSEQGSIDTSVIVQPTFDFSPAIASGLPAFEDFSDFESDNELSSLVKSGGVYRPRACTGSSVVSLGHGSFIGEEDFSLDENETLRFPSPSPPSIKPVDNSHKGKRRKKSSEDTRSVEPVMNTAATAADESQTVEVEQSDRASPAPSESNSSAGADTPSAPLPAPTNRRGRKQSLTEDPSKTFVCDLCNRRFRRQEHLKRHYRSLHTQEKPFECNECGKKFSRSDNLAQHARTHASGGAIVMNLIDNVDPSAYDAGVVAPPSVDDHANYGKVLFQIASEVPGSASELSSEEASDNGKKKRKRSD", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Znf_C2H2_type, Znf_C2H2_type, Znf_C2H2_type, Znf_C2H2_type, Znf_C2H2_type, Znf_C2H2_type that are essential for its biological function; 2. The protein should be classified within Znf_C2H2_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MDSTMMPHTIRQNTIFGKTNFAQQKLGLYQVVAPASPVCSRPGSSCSQPPTLLGNNPGVLTPTGSLSPSSFKPAIMLETEFGDNPYYPSTPPLSTSGSAVGSPKSCDILQTPLNPMFSGLDGFSGVKSGFESIESSILSWTSCDSPPMTPVYIYSQPSRVPSLSSTTSDLSNIPCPSLSPSPAPYARSVSSENDVDFCDPRNLTVSCTSNPSLSDFTLDCLIEEDSSCSEQGSIDTSVIVQPTFDFSPAIASGLPAFEDFSDFESDNELSSLVKSGGVYRPRACTGSSVVSLGHGSFIGEEDFSLDENETLRFPSPSPPSIKPVDNSHKGKRRKKSSEDTRSVEPVMNTAATAADESQTVEVEQSDRASPAPSESNSSAGADTPSAPLPAPTNRRGRKQSLTEDPSKTFVCDLCNRRFRRQEHLKRHYRSLHTQEKPFECNECGKKFSRSDNLAQHARTHASGGAIVMNLIDNVDPSAYDAGVVAPPSVDDHANYGKVLFQIASEVPGSASELSSEEASDNGKKKRKRSD" }, { "InterPro": [ { "InterPro-ID": "IPR002589", "InterPro-Name": "Macro_dom", "InterPro-Type": "DOMAIN", "Beg": 68, "End": 260 }, { "InterPro-ID": "IPR043472", "InterPro-Name": "Macro_dom-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 79, "End": 257 }, { "InterPro-ID": "IPR002589", "InterPro-Name": "Macro_dom", "InterPro-Type": "DOMAIN", "Beg": 80, "End": 222 }, { "InterPro-ID": "IPR043472", "InterPro-Name": "Macro_dom-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 12, "End": 259 }, { "InterPro-ID": "IPR002589", "InterPro-Name": "Macro_dom", "InterPro-Type": "DOMAIN", "Beg": 97, "End": 222 } ], "response#1": "MNNDEQLEFLINYLLDERSESIDIPKTFSEKRNLLRSLMNMRHPSNISEEFLRIQDEFLSRETANKNLTSVEDISLSSGKIMLWQGDITTLSADAIVNAANSKLLGCFIPMHNCIDNIIHSASGLQLREECNRMIMLQGGDEDVGKAKITNAYNLPSKYVVHTVGPSIERGMRVSSDDVKKLERCYNSCLELASEYKLNSIAFCCISTGVFNFPQKKAAEIAIRTVKDFLNSNETSLNHIIFDVFTDKDYDIYKKLLFGN", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Macro_dom, Macro_dom, Macro_dom that are essential for its biological function; 2. The protein should be classified within Macro_dom-like, Macro_dom-like sharing conserved structural features. The designed protein sequence is ", "reference": "MNNDEQLEFLINYLLDERSESIDIPKTFSEKRNLLRSLMNMRHPSNISEEFLRIQDEFLSRETANKNLTSVEDISLSSGKIMLWQGDITTLSADAIVNAANSKLLGCFIPMHNCIDNIIHSASGLQLREECNRMIMLQGGDEDVGKAKITNAYNLPSKYVVHTVGPSIERGMRVSSDDVKKLERCYNSCLELASEYKLNSIAFCCISTGVFNFPQKKAAEIAIRTVKDFLNSNETSLNHIIFDVFTDKDYDIYKKLLFGN" }, { "InterPro": [ { "InterPro-ID": "IPR000719", "InterPro-Name": "Prot_kinase_dom", "InterPro-Type": "DOMAIN", "Beg": 235, "End": 505 }, { "InterPro-ID": "IPR008271", "InterPro-Name": "Ser/Thr_kinase_AS", "InterPro-Type": "ACTIVE_SITE", "Beg": 358, "End": 370 }, { "InterPro-ID": "IPR011009", "InterPro-Name": "Kinase-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 231, "End": 518 }, { "InterPro-ID": "IPR017441", "InterPro-Name": "Protein_kinase_ATP_BS", "InterPro-Type": "BINDING_SITE", "Beg": 241, "End": 264 }, { "InterPro-ID": "IPR000719", "InterPro-Name": "Prot_kinase_dom", "InterPro-Type": "DOMAIN", "Beg": 239, "End": 505 }, { "InterPro-ID": "IPR050915", "InterPro-Name": "MAP_kinase_kinase", "InterPro-Type": "FAMILY", "Beg": 442, "End": 529 } ], "response#1": "MMHNQGNSNGDPAAPMSNLQEPQVPMLSQTPNPVPMMNAPAPLLRPAIPGARGARPPRLGLAIPPSPNVKPVGGNAAGPPLQVPSRPPLPVLHLATPMGSTVAPQEHQPNRGAQPGQSASGGSESSAAHSRTGSFGPLDGRGSNPTSAGSQYSALSFASQYGLGGAKPHGTPDPVSAVGSLYSNASEGGVGMEREGSMHGLEASFDKMSLEKARTSDAEDLDDEGWRIVSMENRIVELGGLGEGAGGAVTRCKLKGGKTVFALKVITTNPDPDIKKQILREINFNKGCASEHICRYYGGFLDPSTATISIAMEFCEGGSLDSIYKEVKRLGGRTGEKVLGKIAEGVLQGLTYLEAKRILHRDIKPSNILLCRNGEVKLCDFGVSGDFGTKGEANTFIGTSYYMAPERITGQTYTITSDVWSTGVTLLEVAQHRFPFPADGTEMQPRAGLIDLLTYIVQQPIPKLKDEPEAGIFWSDNFKHFIEACLEKNPKRRGMPWKMLEHPWMTELKTKRVNMSKYLTQVWGWDDPKGSK", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Prot_kinase_dom, Prot_kinase_dom that are essential for its biological function; 2. The protein should belong to MAP_kinase_kinase that shares evolutionary origin and functional similarity; 3. The protein should be classified within Kinase-like_dom_sf sharing conserved structural features; 4. The protein must have Ser/Thr_kinase_AS that is conserved among related catalytic enzymes; 5. The protein should include a Protein_kinase_ATP_BS that enables ligand binding under diverse conditions. The designed protein sequence is ", "reference": "MMHNQGNSNGDPAAPMSNLQEPQVPMLSQTPNPVPMMNAPAPLLRPAIPGARGARPPRLGLAIPPSPNVKPVGGNAAGPPLQVPSRPPLPVLHLATPMGSTVAPQEHQPNRGAQPGQSASGGSESSAAHSRTGSFGPLDGRGSNPTSAGSQYSALSFASQYGLGGAKPHGTPDPVSAVGSLYSNASEGGVGMEREGSMHGLEASFDKMSLEKARTSDAEDLDDEGWRIVSMENRIVELGGLGEGAGGAVTRCKLKGGKTVFALKVITTNPDPDIKKQILREINFNKGCASEHICRYYGGFLDPSTATISIAMEFCEGGSLDSIYKEVKRLGGRTGEKVLGKIAEGVLQGLTYLEAKRILHRDIKPSNILLCRNGEVKLCDFGVSGDFGTKGEANTFIGTSYYMAPERITGQTYTITSDVWSTGVTLLEVAQHRFPFPADGTEMQPRAGLIDLLTYIVQQPIPKLKDEPEAGIFWSDNFKHFIEACLEKNPKRRGMPWKMLEHPWMTELKTKRVNMSKYLTQVWGWDDPKGSK" }, { "InterPro": [ { "InterPro-ID": "IPR050538", "InterPro-Name": "MAP_kinase_kinase_kinase", "InterPro-Type": "FAMILY", "Beg": 987, "End": 1825 }, { "InterPro-ID": "IPR000719", "InterPro-Name": "Prot_kinase_dom", "InterPro-Type": "DOMAIN", "Beg": 1556, "End": 1825 }, { "InterPro-ID": "IPR011009", "InterPro-Name": "Kinase-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1555, "End": 1824 }, { "InterPro-ID": "IPR000719", "InterPro-Name": "Prot_kinase_dom", "InterPro-Type": "DOMAIN", "Beg": 1559, "End": 1821 }, { "InterPro-ID": "IPR017441", "InterPro-Name": "Protein_kinase_ATP_BS", "InterPro-Type": "BINDING_SITE", "Beg": 1562, "End": 1585 }, { "InterPro-ID": "IPR008271", "InterPro-Name": "Ser/Thr_kinase_AS", "InterPro-Type": "ACTIVE_SITE", "Beg": 1682, "End": 1694 } ], "response#1": "MSKNIQRQRSISSISSRGVDRDRDPASGGLGLLSPYNSRSPLAGLHHSPGSLDATANQLSRPTFLLERKATEDIAKLDGVLFDDIPTLGSSNDHISSLGAGSPYPTINTSLAVTNPNYLSASSPGGPRRRANTASGPLSPAPPASPIDRLSKTTNRGSFVPSTARQPMNSQPPAPASSAPPPKQRTTSPSVASPPSQTRSQTVPYLSSNFGPTANMYGQRQPSGVDPSRPFHQVPLPPPPMSPPPAIGTINSIMTNIPPPPPRYPSAPAAAIHLPGPPGAPPPSGLPPPPGPPPNNTTNWQGTWIGAYGSYIPPPPPQQTHRPYNPQPYKTVNGQTIAIPPPPPPTESMQMSATYIPQGDSYGEGVGIPGLGMDDMAAWSATSQSSWLGGYNSIGSLAPTNASDTAASTPVDAYGSHNRDNSTTSNATSSGASGIPPELAAQWPLDRVLDWLQANNFSNDWRSTFRALDLHGNRFLEVGSANGGRGNFGMMHQLVYPRLAAECISSGTGWDQPREREEGKRMRRLIRHIVKGETPGTGMSSHTRKESISNTSLVPTSAGPDSGSPDTPIKAPGPGFSVGHPGGNHRKLLVGNFDDEGAHRRSPVASEPSEVGITFTERSSSNRGYSPAGSPAPTPGLFSSSTAPNLASSPGGRFGGHRNRNSTDSVSSNAAIYGSGVPPDASQVLRSQMNFGDMAKDTRRYGHDGGNRPSPLGDNASNGDRSAGASEPPGSAKEGKSFLSIFNHRKKKHHDDPDSPTSPMQHKSHSLGSRGNASETSLERPGSSVSTSHEHNTPASSMRSRRITTGRIFILATLDYWNYRMVDVSDVESASDLRQLICINLGLPDADGAQVYLTELGKFDHEDPLDDSQLVANKKVRADAAGSLKVFVRPGNMAGLAVNIGQSQNALSPAHLPAGAKMDEDTYARLNGQRRRSSSSPPASRQNTLTGGEHGKPTSTGADDDENKDPKSDDIAQQAEAHRIEMERKQQAYLAKRKHARENGNSPSENGTGSYTGIVGPKVIDFDEPRNSPFEDKKPFDSAFAPQRRAPAAPLDPSATLIKANSLSKRGSHQRNSQGSVDGFPSKRQGTGMTESPKHISEKRKPTNERQALGGIGAALAGMGRGLGGIAHPGGAGQRGTSPNRSSPGSAGESAGVASSTTDRGEDAKSRKPISSGNVSPTSSARTVSDEPPQLPKVVIKPRIFDGDSSSDEDSDDDSDDGLFAKPLAGRGGDDAAAKGKEPATKPVAKSPMSKHGTFWNDADSDGDEDPISESASNLNKRPSLTVNTKRGRKGLSVTFTSPDLPSSAGSKTAAGDEDDRSSRGSKRTPNTPHSEGWDSNNDKDVKLSRRKSFMEKDTSIWANRPPTDALINNLEDFFPNLDVDQPVLEEGELPGDLPPSPIAEAEEPHDQQQAKSMTTSRISNLYNDSDTLGSDESTLKALERPASIVSVARKNTRRSGGLGRMKSIREVAHKRYTQGAGAPPPVPAAPNNSNNSSSSGSKNSNLMRRKSTKMFNANIVQIRPERGSMILPQIPQDHLPSLPHNANNQIPKRQTTFRWFKGQLIGKGTYGRVYLGMNATTGEFLAVKEVEVNPKAAGGDKNKMKELVAALDQEIDTMQHLDHVNIVQYLGCERKETSISIFLEYIPGGSIGSCLRKHGKFEESVVSSLTRQTLSGLAYLHREGILHRDLKADNILLDVDGTAKISDFGISKKTDNIYGNDKTNSMQGSVFWMAPEVIRSQGEGYSAKVDIWSLGCVVLEMFAGRRPWSKDEAVGAIYKIANGETPPIPEEVSAAVTPVALSFMWDCFSVNPEERPTATKLLAEHPFCVFRDDYDFDQTELYAKIKGTWNTK", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Prot_kinase_dom, Prot_kinase_dom that are essential for its biological function; 2. The protein should belong to MAP_kinase_kinase_kinase that shares evolutionary origin and functional similarity; 3. The protein should be classified within Kinase-like_dom_sf sharing conserved structural features; 4. The protein must have Ser/Thr_kinase_AS that is conserved among related catalytic enzymes; 5. The protein should include a Protein_kinase_ATP_BS that enables ligand binding under diverse conditions. The designed protein sequence is ", "reference": "MSKNIQRQRSISSISSRGVDRDRDPASGGLGLLSPYNSRSPLAGLHHSPGSLDATANQLSRPTFLLERKATEDIAKLDGVLFDDIPTLGSSNDHISSLGAGSPYPTINTSLAVTNPNYLSASSPGGPRRRANTASGPLSPAPPASPIDRLSKTTNRGSFVPSTARQPMNSQPPAPASSAPPPKQRTTSPSVASPPSQTRSQTVPYLSSNFGPTANMYGQRQPSGVDPSRPFHQVPLPPPPMSPPPAIGTINSIMTNIPPPPPRYPSAPAAAIHLPGPPGAPPPSGLPPPPGPPPNNTTNWQGTWIGAYGSYIPPPPPQQTHRPYNPQPYKTVNGQTIAIPPPPPPTESMQMSATYIPQGDSYGEGVGIPGLGMDDMAAWSATSQSSWLGGYNSIGSLAPTNASDTAASTPVDAYGSHNRDNSTTSNATSSGASGIPPELAAQWPLDRVLDWLQANNFSNDWRSTFRALDLHGNRFLEVGSANGGRGNFGMMHQLVYPRLAAECISSGTGWDQPREREEGKRMRRLIRHIVKGETPGTGMSSHTRKESISNTSLVPTSAGPDSGSPDTPIKAPGPGFSVGHPGGNHRKLLVGNFDDEGAHRRSPVASEPSEVGITFTERSSSNRGYSPAGSPAPTPGLFSSSTAPNLASSPGGRFGGHRNRNSTDSVSSNAAIYGSGVPPDASQVLRSQMNFGDMAKDTRRYGHDGGNRPSPLGDNASNGDRSAGASEPPGSAKEGKSFLSIFNHRKKKHHDDPDSPTSPMQHKSHSLGSRGNASETSLERPGSSVSTSHEHNTPASSMRSRRITTGRIFILATLDYWNYRMVDVSDVESASDLRQLICINLGLPDADGAQVYLTELGKFDHEDPLDDSQLVANKKVRADAAGSLKVFVRPGNMAGLAVNIGQSQNALSPAHLPAGAKMDEDTYARLNGQRRRSSSSPPASRQNTLTGGEHGKPTSTGADDDENKDPKSDDIAQQAEAHRIEMERKQQAYLAKRKHARENGNSPSENGTGSYTGIVGPKVIDFDEPRNSPFEDKKPFDSAFAPQRRAPAAPLDPSATLIKANSLSKRGSHQRNSQGSVDGFPSKRQGTGMTESPKHISEKRKPTNERQALGGIGAALAGMGRGLGGIAHPGGAGQRGTSPNRSSPGSAGESAGVASSTTDRGEDAKSRKPISSGNVSPTSSARTVSDEPPQLPKVVIKPRIFDGDSSSDEDSDDDSDDGLFAKPLAGRGGDDAAAKGKEPATKPVAKSPMSKHGTFWNDADSDGDEDPISESASNLNKRPSLTVNTKRGRKGLSVTFTSPDLPSSAGSKTAAGDEDDRSSRGSKRTPNTPHSEGWDSNNDKDVKLSRRKSFMEKDTSIWANRPPTDALINNLEDFFPNLDVDQPVLEEGELPGDLPPSPIAEAEEPHDQQQAKSMTTSRISNLYNDSDTLGSDESTLKALERPASIVSVARKNTRRSGGLGRMKSIREVAHKRYTQGAGAPPPVPAAPNNSNNSSSSGSKNSNLMRRKSTKMFNANIVQIRPERGSMILPQIPQDHLPSLPHNANNQIPKRQTTFRWFKGQLIGKGTYGRVYLGMNATTGEFLAVKEVEVNPKAAGGDKNKMKELVAALDQEIDTMQHLDHVNIVQYLGCERKETSISIFLEYIPGGSIGSCLRKHGKFEESVVSSLTRQTLSGLAYLHREGILHRDLKADNILLDVDGTAKISDFGISKKTDNIYGNDKTNSMQGSVFWMAPEVIRSQGEGYSAKVDIWSLGCVVLEMFAGRRPWSKDEAVGAIYKIANGETPPIPEEVSAAVTPVALSFMWDCFSVNPEERPTATKLLAEHPFCVFRDDYDFDQTELYAKIKGTWNTK" }, { "InterPro": [ { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 26, "End": 100 }, { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 26, "End": 103 } ], "response#1": "MFARCAATILALALATLTAATPTGQCNVGNQQCCNTVQEASSDPAAGLLALLGVNVQDVTGLVGLTCNPITAIGGLNSNCDASPVCCENNSFGSLISIGCVPISL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Hydrophobin, Hydrophobin that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MFARCAATILALALATLTAATPTGQCNVGNQQCCNTVQEASSDPAAGLLALLGVNVQDVTGLVGLTCNPITAIGGLNSNCDASPVCCENNSFGSLISIGCVPISL" }, { "InterPro": [ { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 26, "End": 100 }, { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 26, "End": 103 } ], "response#1": "MFARCAATIFALALATLTAATPTGQCNVGNQQCCNTVQEASSDPAAGILALLGVNVQDVTGLVGLTCNPITGIGGLNSNCDASPVCCENNSFGSLISLGCVPISL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Hydrophobin, Hydrophobin that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MFARCAATIFALALATLTAATPTGQCNVGNQQCCNTVQEASSDPAAGILALLGVNVQDVTGLVGLTCNPITGIGGLNSNCDASPVCCENNSFGSLISLGCVPISL" }, { "InterPro": [ { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 43, "End": 117 }, { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 43, "End": 120 } ], "response#1": "MFARSAATILAFVLVTLTAATPAYYAPGTKTTSVDKAVPAGQCNVGNQQCCNTVQEASSNPVAGLLGLLGVNVQDVTGLVGLTCNPITGIGGLNSNCDASPVCCENNSFGSLISIGCIPISL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Hydrophobin, Hydrophobin that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MFARSAATILAFVLVTLTAATPAYYAPGTKTTSVDKAVPAGQCNVGNQQCCNTVQEASSNPVAGLLGLLGVNVQDVTGLVGLTCNPITGIGGLNSNCDASPVCCENNSFGSLISIGCIPISL" }, { "InterPro": [ { "InterPro-ID": "IPR036390", "InterPro-Name": "WH_DNA-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 15, "End": 118 }, { "InterPro-ID": "IPR016461", "InterPro-Name": "COMT-like", "InterPro-Type": "FAMILY", "Beg": 1, "End": 362 }, { "InterPro-ID": "IPR036388", "InterPro-Name": "WH-like_DNA-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 3, "End": 114 }, { "InterPro-ID": "IPR016461", "InterPro-Name": "COMT-like", "InterPro-Type": "FAMILY", "Beg": 23, "End": 362 }, { "InterPro-ID": "IPR029063", "InterPro-Name": "SAM-dependent_MTases_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 115, "End": 362 }, { "InterPro-ID": "IPR001077", "InterPro-Name": "O_MeTrfase_dom", "InterPro-Type": "DOMAIN", "Beg": 139, "End": 344 }, { "InterPro-ID": "IPR016461", "InterPro-Name": "COMT-like", "InterPro-Type": "FAMILY", "Beg": 21, "End": 344 }, { "InterPro-ID": "IPR012967", "InterPro-Name": "Plant_O-MeTrfase_dimerisation", "InterPro-Type": "DOMAIN", "Beg": 15, "End": 116 }, { "InterPro-ID": "IPR029063", "InterPro-Name": "SAM-dependent_MTases_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 120, "End": 359 } ], "response#1": "MGSASGSAERTQMGEDEACSFAMTITSGSVPPMVLKAVIELDVLEIIKRAGPGAHLSPAEIAAQLPTTNPGAAAMLDRMLRLLASYDVLSYSLHTLPDGRVERLYGLAPVCQFLTNNEDGVTLSALSLMNQDKVLMESWYHLKDAVLDGGIPFNKAYGMTAFEYHGTDPRFNKVFNNGMSNHSTITMKKLLENYKGFEGVSTLVDVGGGTGATLNMIISKHPTIKGINFDLPHVIEDAPTYPGVEHIGGDMFVSVPKGDAIFMKWICHDWSDEHCLRFLKNCYAALADHGKVIVCEYILPVAPETNHAARTVFHVDAIMLAHNPGGKERTEQEFESLAKGAGFEGFRVACSAYGTKVMEFLKKN", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more O_MeTrfase_dom, Plant_O-MeTrfase_dimerisation that are essential for its biological function; 2. The protein should belong to COMT-like, COMT-like, COMT-like that shares evolutionary origin and functional similarity; 3. The protein should be classified within WH_DNA-bd_sf, WH-like_DNA-bd_sf, SAM-dependent_MTases_sf, SAM-dependent_MTases_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MGSASGSAERTQMGEDEACSFAMTITSGSVPPMVLKAVIELDVLEIIKRAGPGAHLSPAEIAAQLPTTNPGAAAMLDRMLRLLASYDVLSYSLHTLPDGRVERLYGLAPVCQFLTNNEDGVTLSALSLMNQDKVLMESWYHLKDAVLDGGIPFNKAYGMTAFEYHGTDPRFNKVFNNGMSNHSTITMKKLLENYKGFEGVSTLVDVGGGTGATLNMIISKHPTIKGINFDLPHVIEDAPTYPGVEHIGGDMFVSVPKGDAIFMKWICHDWSDEHCLRFLKNCYAALADHGKVIVCEYILPVAPETNHAARTVFHVDAIMLAHNPGGKERTEQEFESLAKGAGFEGFRVACSAYGTKVMEFLKKN" }, { "InterPro": [ { "InterPro-ID": "IPR036390", "InterPro-Name": "WH_DNA-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 35, "End": 141 }, { "InterPro-ID": "IPR001077", "InterPro-Name": "O_MeTrfase_dom", "InterPro-Type": "DOMAIN", "Beg": 163, "End": 368 }, { "InterPro-ID": "IPR016461", "InterPro-Name": "COMT-like", "InterPro-Type": "FAMILY", "Beg": 22, "End": 386 }, { "InterPro-ID": "IPR029063", "InterPro-Name": "SAM-dependent_MTases_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 139, "End": 386 }, { "InterPro-ID": "IPR029063", "InterPro-Name": "SAM-dependent_MTases_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 144, "End": 384 }, { "InterPro-ID": "IPR016461", "InterPro-Name": "COMT-like", "InterPro-Type": "FAMILY", "Beg": 45, "End": 386 }, { "InterPro-ID": "IPR036388", "InterPro-Name": "WH-like_DNA-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 23, "End": 138 }, { "InterPro-ID": "IPR016461", "InterPro-Name": "COMT-like", "InterPro-Type": "FAMILY", "Beg": 43, "End": 367 }, { "InterPro-ID": "IPR012967", "InterPro-Name": "Plant_O-MeTrfase_dimerisation", "InterPro-Type": "DOMAIN", "Beg": 37, "End": 140 } ], "response#1": "MAEIPTSSNPSDDPETQKLNGNEEDYDHHHDEDPESDDENYEYALQIAEMLPFPMVMKTAIELDLLGIIATAGPDRQLSAAEIAAALPAAGNPDAPAMLDRMLYLLATYSVVTCTAVDGGASGGVVRKYGLAPVAKYFVSNEDGVSLGALISLNQGQAFLASWSKLKEAVLEGGIPFNKVHGMDVFHYQGTDPRFNEIFNKAMYDQSTYIIKKIVRRYKGFENIQRLVDVGGGLGHTLRVITSNYPSIKGINFDLPHVIQHAPTIPGVEHVGGDMFESIPNGDAIFMKCILHDWSDEHCLKILKNCYKALPRKGKVIVVEMNMIEEPQTTPLAKAISQLDVCMMTQSPGGKERTRREFQTLAEAAGFAEFNPVCHVAGFWVMEFLK", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more O_MeTrfase_dom, Plant_O-MeTrfase_dimerisation that are essential for its biological function; 2. The protein should belong to COMT-like, COMT-like, COMT-like that shares evolutionary origin and functional similarity; 3. The protein should be classified within WH_DNA-bd_sf, SAM-dependent_MTases_sf, SAM-dependent_MTases_sf, WH-like_DNA-bd_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MAEIPTSSNPSDDPETQKLNGNEEDYDHHHDEDPESDDENYEYALQIAEMLPFPMVMKTAIELDLLGIIATAGPDRQLSAAEIAAALPAAGNPDAPAMLDRMLYLLATYSVVTCTAVDGGASGGVVRKYGLAPVAKYFVSNEDGVSLGALISLNQGQAFLASWSKLKEAVLEGGIPFNKVHGMDVFHYQGTDPRFNEIFNKAMYDQSTYIIKKIVRRYKGFENIQRLVDVGGGLGHTLRVITSNYPSIKGINFDLPHVIQHAPTIPGVEHVGGDMFESIPNGDAIFMKCILHDWSDEHCLKILKNCYKALPRKGKVIVVEMNMIEEPQTTPLAKAISQLDVCMMTQSPGGKERTRREFQTLAEAAGFAEFNPVCHVAGFWVMEFLK" }, { "InterPro": [ { "InterPro-ID": "IPR029063", "InterPro-Name": "SAM-dependent_MTases_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 139, "End": 386 }, { "InterPro-ID": "IPR016461", "InterPro-Name": "COMT-like", "InterPro-Type": "FAMILY", "Beg": 45, "End": 386 }, { "InterPro-ID": "IPR036390", "InterPro-Name": "WH_DNA-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 35, "End": 141 }, { "InterPro-ID": "IPR016461", "InterPro-Name": "COMT-like", "InterPro-Type": "FAMILY", "Beg": 22, "End": 386 }, { "InterPro-ID": "IPR001077", "InterPro-Name": "O_MeTrfase_dom", "InterPro-Type": "DOMAIN", "Beg": 163, "End": 368 }, { "InterPro-ID": "IPR036388", "InterPro-Name": "WH-like_DNA-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 23, "End": 138 }, { "InterPro-ID": "IPR029063", "InterPro-Name": "SAM-dependent_MTases_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 144, "End": 383 }, { "InterPro-ID": "IPR016461", "InterPro-Name": "COMT-like", "InterPro-Type": "FAMILY", "Beg": 43, "End": 367 }, { "InterPro-ID": "IPR012967", "InterPro-Name": "Plant_O-MeTrfase_dimerisation", "InterPro-Type": "DOMAIN", "Beg": 37, "End": 140 } ], "response#1": "MAEIPTSSNPSDDLETQKLNGNEEDYDHHHDEDPESDDENYEYALQIAEMLPFPMVMKTAIELDLLGIIATAGPDRQLSAAEIAAALPAAGNPDAPAMLDRMLYLLATYSVVTCTAVDGGASGGVVRKYGLAPVAKYFVSNKDGVSLGALISLNQGQAFLASWSKLKEAVLEGGIPFNKFHGMEVFHYQGTDPRFNEIFNKAMYDQSTYTIKKIVRRYKGFENIQRLVDVGGGLGHTLRVITSNYPSIKGINFDLPHVIQHAPTIPGVEHVGGDMFESIPNGDAIFMKCLLHDWSDEHCLKILKNCYKALPRKGKVIVVEMNMIEEPQTTPLAKAISQLDVGMMTQSPGGKERTRREFQTLAEAAGFAEFNPVCHVACFWVMEFLK", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more O_MeTrfase_dom, Plant_O-MeTrfase_dimerisation that are essential for its biological function; 2. The protein should belong to COMT-like, COMT-like, COMT-like that shares evolutionary origin and functional similarity; 3. The protein should be classified within SAM-dependent_MTases_sf, WH_DNA-bd_sf, WH-like_DNA-bd_sf, SAM-dependent_MTases_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MAEIPTSSNPSDDLETQKLNGNEEDYDHHHDEDPESDDENYEYALQIAEMLPFPMVMKTAIELDLLGIIATAGPDRQLSAAEIAAALPAAGNPDAPAMLDRMLYLLATYSVVTCTAVDGGASGGVVRKYGLAPVAKYFVSNKDGVSLGALISLNQGQAFLASWSKLKEAVLEGGIPFNKFHGMEVFHYQGTDPRFNEIFNKAMYDQSTYTIKKIVRRYKGFENIQRLVDVGGGLGHTLRVITSNYPSIKGINFDLPHVIQHAPTIPGVEHVGGDMFESIPNGDAIFMKCLLHDWSDEHCLKILKNCYKALPRKGKVIVVEMNMIEEPQTTPLAKAISQLDVGMMTQSPGGKERTRREFQTLAEAAGFAEFNPVCHVACFWVMEFLK" }, { "InterPro": [ { "InterPro-ID": "IPR013087", "InterPro-Name": "Znf_C2H2_type", "InterPro-Type": "DOMAIN", "Beg": 376, "End": 399 }, { "InterPro-ID": "IPR013087", "InterPro-Name": "Znf_C2H2_type", "InterPro-Type": "DOMAIN", "Beg": 405, "End": 427 }, { "InterPro-ID": "IPR036236", "InterPro-Name": "Znf_C2H2_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 374, "End": 427 }, { "InterPro-ID": "IPR013087", "InterPro-Name": "Znf_C2H2_type", "InterPro-Type": "DOMAIN", "Beg": 407, "End": 427 }, { "InterPro-ID": "IPR013087", "InterPro-Name": "Znf_C2H2_type", "InterPro-Type": "DOMAIN", "Beg": 405, "End": 432 }, { "InterPro-ID": "IPR051059", "InterPro-Name": "VerF-like", "InterPro-Type": "FAMILY", "Beg": 346, "End": 443 }, { "InterPro-ID": "IPR013087", "InterPro-Name": "Znf_C2H2_type", "InterPro-Type": "DOMAIN", "Beg": 376, "End": 404 }, { "InterPro-ID": "IPR013087", "InterPro-Name": "Znf_C2H2_type", "InterPro-Type": "DOMAIN", "Beg": 378, "End": 399 } ], "response#1": "MEAAMLQPQSVAQAFLNNREFKSDARKAYLFQQMPATPIYSRPGSSCSQPPTLYSNGAHKTTMLDADVYDSHFPSTPPLSTSGSAIGSPKMFDALQTPINPMFSGLDGFPGKDLFDSVETSVLDWSSCASPPMTPVYIASHPLALQQSTSDLVSMTSCPSLSPSPSPAYARSIASEQDVDFCDPRNLTVSTGNPTLAPEFTLSNMGDADVKGANARPTFDFNPAISHDLPSFQNLDDLDSEDDFSNLVNIEATATGETTRPRACTGSSVVSLGHCSFDDELAFDDNDTFSFLPFPSADATTDVDDGHRDKKLKTSPKNDAVVASEPTDDEVEATSAASVSSESTVSSPSDDNSPTVSAPSRRGRKQSLTEDPSKTFVCDLCNRRFRRQEHLKRHYRSLHTQEKPFECNECGKKFSRSDNLAQHARTHSGGAIVMDLIEDHASHFDGSAMPVNAGDEFSYGKVMFQIGSEVSEITEDASDNKKKRKRTD", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Znf_C2H2_type, Znf_C2H2_type, Znf_C2H2_type, Znf_C2H2_type, Znf_C2H2_type, Znf_C2H2_type that are essential for its biological function; 2. The protein should belong to VerF-like that shares evolutionary origin and functional similarity; 3. The protein should be classified within Znf_C2H2_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MEAAMLQPQSVAQAFLNNREFKSDARKAYLFQQMPATPIYSRPGSSCSQPPTLYSNGAHKTTMLDADVYDSHFPSTPPLSTSGSAIGSPKMFDALQTPINPMFSGLDGFPGKDLFDSVETSVLDWSSCASPPMTPVYIASHPLALQQSTSDLVSMTSCPSLSPSPSPAYARSIASEQDVDFCDPRNLTVSTGNPTLAPEFTLSNMGDADVKGANARPTFDFNPAISHDLPSFQNLDDLDSEDDFSNLVNIEATATGETTRPRACTGSSVVSLGHCSFDDELAFDDNDTFSFLPFPSADATTDVDDGHRDKKLKTSPKNDAVVASEPTDDEVEATSAASVSSESTVSSPSDDNSPTVSAPSRRGRKQSLTEDPSKTFVCDLCNRRFRRQEHLKRHYRSLHTQEKPFECNECGKKFSRSDNLAQHARTHSGGAIVMDLIEDHASHFDGSAMPVNAGDEFSYGKVMFQIGSEVSEITEDASDNKKKRKRTD" }, { "InterPro": [ { "InterPro-ID": "IPR036396", "InterPro-Name": "Cyt_P450_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 31, "End": 497 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 36, "End": 491 }, { "InterPro-ID": "IPR017972", "InterPro-Name": "Cyt_P450_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 437, "End": 446 }, { "InterPro-ID": "IPR036396", "InterPro-Name": "Cyt_P450_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 24, "End": 496 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 313, "End": 339 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 357, "End": 375 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 444, "End": 467 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 434, "End": 444 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 398, "End": 422 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 293, "End": 310 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 63, "End": 82 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 444, "End": 455 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 435, "End": 444 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 358, "End": 369 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 304, "End": 321 } ], "response#1": "MGYYAIFAVVLPFLWTCFYLLKLNPTSKLTSTIRLPPGPRPLPIIGNLHQLGERPHRTLANLAKVYGPIISLKFGSITTIAVSSADVAKEMFQKHDLALASRKVPAAVRANGHDNFSVAWLPVTPKWRFLRKISAIQLFSTQRLDARQSLRQAKVVELLDYIKARSNAGEPVDIGEAAFTTSLNLLSNTFFSMDLASYSSAASGEFKELVWKIMEEIGKPNLADCFPLVGFISRMSVNRELMGYGNKLNEVFAEIIEKRLSAANSSEGRGNGDVLDTLLRIMEEDDSELSLDDIMHLLMDFFTAGTDTTSSTLEWAMTELLHNPEKMAKAQAELEQVLGKDTVSIQESDIAKLLYLQATVKETLRMHPPTVFLLPRKADSDIDLYGHLVPKNAQVFVNLWAISYDPSTWENPDLFSPERFLDQDIDMKGQDFGFIPFGAGRRICPGLTLAYRMLNLMLGTLIHVFNWKLGDGLSREDLDMTDKFGITIQKAKPLRAIPILK", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Cyt_P450, Cyt_P450_E_grp-I, Cyt_P450_E_grp-I, Cyt_P450_E_grp-I, Cyt_P450_E_grp-I, Cyt_P450_E_grp-I, Cyt_P450_E_grp-I, Cyt_P450_E_grp-I, Cyt_P450, Cyt_P450, Cyt_P450, Cyt_P450 that shares evolutionary origin and functional similarity; 2. The protein should be classified within Cyt_P450_sf, Cyt_P450_sf sharing conserved structural features; 3. The protein should contain Cyt_P450_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MGYYAIFAVVLPFLWTCFYLLKLNPTSKLTSTIRLPPGPRPLPIIGNLHQLGERPHRTLANLAKVYGPIISLKFGSITTIAVSSADVAKEMFQKHDLALASRKVPAAVRANGHDNFSVAWLPVTPKWRFLRKISAIQLFSTQRLDARQSLRQAKVVELLDYIKARSNAGEPVDIGEAAFTTSLNLLSNTFFSMDLASYSSAASGEFKELVWKIMEEIGKPNLADCFPLVGFISRMSVNRELMGYGNKLNEVFAEIIEKRLSAANSSEGRGNGDVLDTLLRIMEEDDSELSLDDIMHLLMDFFTAGTDTTSSTLEWAMTELLHNPEKMAKAQAELEQVLGKDTVSIQESDIAKLLYLQATVKETLRMHPPTVFLLPRKADSDIDLYGHLVPKNAQVFVNLWAISYDPSTWENPDLFSPERFLDQDIDMKGQDFGFIPFGAGRRICPGLTLAYRMLNLMLGTLIHVFNWKLGDGLSREDLDMTDKFGITIQKAKPLRAIPILK" }, { "InterPro": [ { "InterPro-ID": "IPR036514", "InterPro-Name": "SGNH_hydro_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 22, "End": 354 }, { "InterPro-ID": "IPR001087", "InterPro-Name": "GDSL", "InterPro-Type": "FAMILY", "Beg": 29, "End": 348 }, { "InterPro-ID": "IPR035669", "InterPro-Name": "SGNH_plant_lipase-like", "InterPro-Type": "FAMILY", "Beg": 27, "End": 352 } ], "response#1": "MGFAPLLVFSLFVFAGTTKGFICSFDSIYQLGDSFSDTGNLIRQPPDGPTFCSAHFPYGETFPGMPTGRCSDGRLIIDFIATALNLPLLNPYLQQNVSFRHGVNFAVGGATALDLSFLAARGVQVYDVHSPLSTQLKWFRTYLGSICSSPKECSNKLKNALFILGNIGNNDVNYAFPNRSIEEIRAYLPFITEAVANATREIIRLGGTRVIVPGMFPLGCLARNLYFFPDGDKDDLGCLSSLNDLSIYFNSLIQQALASLRIEFPQAVIIYADYYNAWGFLFRNGPALGFNSTTMLKCCCGIGGPYNYDPDRECASQGVPVCSNPTEYIQWDGTHFTQAAYRRVAEYIIPDIIKELKCSYSSIQHLTEGREALHINERE", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to GDSL, SGNH_plant_lipase-like that shares evolutionary origin and functional similarity; 2. The protein should be classified within SGNH_hydro_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MGFAPLLVFSLFVFAGTTKGFICSFDSIYQLGDSFSDTGNLIRQPPDGPTFCSAHFPYGETFPGMPTGRCSDGRLIIDFIATALNLPLLNPYLQQNVSFRHGVNFAVGGATALDLSFLAARGVQVYDVHSPLSTQLKWFRTYLGSICSSPKECSNKLKNALFILGNIGNNDVNYAFPNRSIEEIRAYLPFITEAVANATREIIRLGGTRVIVPGMFPLGCLARNLYFFPDGDKDDLGCLSSLNDLSIYFNSLIQQALASLRIEFPQAVIIYADYYNAWGFLFRNGPALGFNSTTMLKCCCGIGGPYNYDPDRECASQGVPVCSNPTEYIQWDGTHFTQAAYRRVAEYIIPDIIKELKCSYSSIQHLTEGREALHINERE" }, { "InterPro": [ { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 311, "End": 328 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 441, "End": 450 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 364, "End": 375 }, { "InterPro-ID": "IPR017972", "InterPro-Name": "Cyt_P450_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 443, "End": 452 }, { "InterPro-ID": "IPR036396", "InterPro-Name": "Cyt_P450_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 40, "End": 501 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 40, "End": 486 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 68, "End": 87 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 92, "End": 113 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 363, "End": 381 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 450, "End": 473 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 300, "End": 317 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 404, "End": 428 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 440, "End": 450 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 320, "End": 346 }, { "InterPro-ID": "IPR036396", "InterPro-Name": "Cyt_P450_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 32, "End": 496 } ], "response#1": "MEIMNFSLNSPVFLLLSFFFLLMVLMQLTGSRKYKGKRLPPGPKKLPIIGNLHQMVGSLPHRVLKNLADQYGPVMHLQIGELSAIVISSADKAKEVLNTHGILVADRPQTTVAKIMLYNSLGATFAPYGDYLKQLRQIYALELLSPKTVRSFWTIMEDELSTMVTSVKAEAGQPIVLHDRMLTYLYATLCRATVGSVCNGRETLIMAAKETSALSAAIRIEDLFPSVKILPVVSGLRTRLTNLLKQLDTVLEDIIGEREKKMFSSNNIQPSTEEEDMLGVLLLYKNGKGKDTKFRITNNDIKAIIFELILAGTLSSSAIVEWCMSEMIKNPRVMKKAQDEVRQVLKDKKKVSGSDLAKLEYVKMVIKESVRLHPPAPLLFPREVREDFEMDGMIIPKKSWVIINYWAVGIDPKIWDDAERFEPERFSNSPIDFYGSHFELIPFGAGRRICPGILFGTTNVELLLASFLYHFDWKLPGGMKPEELDMNELFGAGCIRENPLCLIPSISVAGN", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Cyt_P450, Cyt_P450, Cyt_P450, Cyt_P450, Cyt_P450_E_grp-I, Cyt_P450_E_grp-I, Cyt_P450_E_grp-I, Cyt_P450_E_grp-I, Cyt_P450_E_grp-I, Cyt_P450_E_grp-I, Cyt_P450_E_grp-I, Cyt_P450_E_grp-I that shares evolutionary origin and functional similarity; 2. The protein should be classified within Cyt_P450_sf, Cyt_P450_sf sharing conserved structural features; 3. The protein should contain Cyt_P450_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MEIMNFSLNSPVFLLLSFFFLLMVLMQLTGSRKYKGKRLPPGPKKLPIIGNLHQMVGSLPHRVLKNLADQYGPVMHLQIGELSAIVISSADKAKEVLNTHGILVADRPQTTVAKIMLYNSLGATFAPYGDYLKQLRQIYALELLSPKTVRSFWTIMEDELSTMVTSVKAEAGQPIVLHDRMLTYLYATLCRATVGSVCNGRETLIMAAKETSALSAAIRIEDLFPSVKILPVVSGLRTRLTNLLKQLDTVLEDIIGEREKKMFSSNNIQPSTEEEDMLGVLLLYKNGKGKDTKFRITNNDIKAIIFELILAGTLSSSAIVEWCMSEMIKNPRVMKKAQDEVRQVLKDKKKVSGSDLAKLEYVKMVIKESVRLHPPAPLLFPREVREDFEMDGMIIPKKSWVIINYWAVGIDPKIWDDAERFEPERFSNSPIDFYGSHFELIPFGAGRRICPGILFGTTNVELLLASFLYHFDWKLPGGMKPEELDMNELFGAGCIRENPLCLIPSISVAGN" }, { "InterPro": [ { "InterPro-ID": "IPR047109", "InterPro-Name": "CAD-like", "InterPro-Type": "FAMILY", "Beg": 12, "End": 360 }, { "InterPro-ID": "IPR002328", "InterPro-Name": "ADH_Zn_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 72, "End": 86 }, { "InterPro-ID": "IPR013149", "InterPro-Name": "ADH-like_C", "InterPro-Type": "DOMAIN", "Beg": 197, "End": 321 }, { "InterPro-ID": "IPR013154", "InterPro-Name": "ADH-like_N", "InterPro-Type": "DOMAIN", "Beg": 38, "End": 157 }, { "InterPro-ID": "IPR047109", "InterPro-Name": "CAD-like", "InterPro-Type": "FAMILY", "Beg": 15, "End": 356 }, { "InterPro-ID": "IPR036291", "InterPro-Name": "NAD(P)-bd_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 162, "End": 325 }, { "InterPro-ID": "IPR011032", "InterPro-Name": "GroES-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 22, "End": 188 } ], "response#1": "MAGETTQLDLSVKAVGWGAADASGTLQPIKFYRRTPGERDVKIRVLYCGVCNFDMEMVRNKWGFTRYPYVFGHETAGEVIEVGSKVQKFKVGDKVGVGCMVGSCGKCFNCQNGMENYCPEPNMADGSVYREQQGEPSFGGCSNVMVVDEKFVLRWPENLPQDTGVPLLCAGIVVYSPMKYMGLDKPGKHIGVIGLGGLGSIAVKFIKAFGGKATVISTSKRKEKEAIEEHGADAFVVNTDTEKLQALAGTMDGVVDTTPGGRTPMSLMLNLLKFDGVVLLVGAPETLFELPVQPLILGRRKIIGSSTGGLKEYQETLDFAAQHNIVCDTEVIGIDYLSTAMERIKNLDVKYRFAIDIGNTLKYED", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more ADH-like_C, ADH-like_N that are essential for its biological function; 2. The protein should belong to CAD-like, CAD-like that shares evolutionary origin and functional similarity; 3. The protein should be classified within NAD(P)-bd_dom_sf, GroES-like_sf sharing conserved structural features; 4. The protein should contain ADH_Zn_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MAGETTQLDLSVKAVGWGAADASGTLQPIKFYRRTPGERDVKIRVLYCGVCNFDMEMVRNKWGFTRYPYVFGHETAGEVIEVGSKVQKFKVGDKVGVGCMVGSCGKCFNCQNGMENYCPEPNMADGSVYREQQGEPSFGGCSNVMVVDEKFVLRWPENLPQDTGVPLLCAGIVVYSPMKYMGLDKPGKHIGVIGLGGLGSIAVKFIKAFGGKATVISTSKRKEKEAIEEHGADAFVVNTDTEKLQALAGTMDGVVDTTPGGRTPMSLMLNLLKFDGVVLLVGAPETLFELPVQPLILGRRKIIGSSTGGLKEYQETLDFAAQHNIVCDTEVIGIDYLSTAMERIKNLDVKYRFAIDIGNTLKYED" }, { "InterPro": [ { "InterPro-ID": "IPR050823", "InterPro-Name": "Plant_Ser_Thr_Prot_Kinase", "InterPro-Type": "FAMILY", "Beg": 59, "End": 371 }, { "InterPro-ID": "IPR008271", "InterPro-Name": "Ser/Thr_kinase_AS", "InterPro-Type": "ACTIVE_SITE", "Beg": 217, "End": 229 }, { "InterPro-ID": "IPR001245", "InterPro-Name": "Ser-Thr/Tyr_kinase_cat_dom", "InterPro-Type": "DOMAIN", "Beg": 95, "End": 368 }, { "InterPro-ID": "IPR011009", "InterPro-Name": "Kinase-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 67, "End": 369 }, { "InterPro-ID": "IPR000719", "InterPro-Name": "Prot_kinase_dom", "InterPro-Type": "DOMAIN", "Beg": 91, "End": 383 } ], "response#1": "MVASKIAWKFILPNCFKAKNDRNILPSETKIIQICKQINSDHHHSRLAISDISTDSRSVFISLDDLSSNAIIGSNLHIFTYAELKIITSKFSSANFLGKGGFGPVHKGFIDDKIKPGLKAQPVAVKLLDLDGNQGHQEWLTEVVFLGQLRHPHLVKLIGYCWEEEQRLLVYEYMARGNLENHLFSRYSSCLPWSTRIKIAVGAAKGLAFLHGEEKPVIYRDFKASNILLDSDYKAKLSDFGLAKDGPEGDDTHVSTRVMGTHGYAAPEYIMTGHLTSKSDVYSFGVVLLELITGRPAMDKNRPIRERNLVDWARPMLRDFHKLDRIMDPRLEGQYSTEGAKKVAALAYQCLSHQPRSRPTMSNVVKSLEPISELTDIPIGPFVYVVPSSECDKELEIGALKSKLDEEKKMNVNEDEQKGARRHGHRHKHRPKSSAAAAAVYSDTHMQNFALSHERTNKKHILK", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Ser-Thr/Tyr_kinase_cat_dom, Prot_kinase_dom that are essential for its biological function; 2. The protein should belong to Plant_Ser_Thr_Prot_Kinase that shares evolutionary origin and functional similarity; 3. The protein should be classified within Kinase-like_dom_sf sharing conserved structural features; 4. The protein must have Ser/Thr_kinase_AS that is conserved among related catalytic enzymes. The designed protein sequence is ", "reference": "MVASKIAWKFILPNCFKAKNDRNILPSETKIIQICKQINSDHHHSRLAISDISTDSRSVFISLDDLSSNAIIGSNLHIFTYAELKIITSKFSSANFLGKGGFGPVHKGFIDDKIKPGLKAQPVAVKLLDLDGNQGHQEWLTEVVFLGQLRHPHLVKLIGYCWEEEQRLLVYEYMARGNLENHLFSRYSSCLPWSTRIKIAVGAAKGLAFLHGEEKPVIYRDFKASNILLDSDYKAKLSDFGLAKDGPEGDDTHVSTRVMGTHGYAAPEYIMTGHLTSKSDVYSFGVVLLELITGRPAMDKNRPIRERNLVDWARPMLRDFHKLDRIMDPRLEGQYSTEGAKKVAALAYQCLSHQPRSRPTMSNVVKSLEPISELTDIPIGPFVYVVPSSECDKELEIGALKSKLDEEKKMNVNEDEQKGARRHGHRHKHRPKSSAAAAAVYSDTHMQNFALSHERTNKKHILK" }, { "InterPro": [ { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 33, "End": 107 }, { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 33, "End": 110 } ], "response#1": "MFSAAISVFVLATLTAATPMARGIIPAPPAGQCNVGTQQCCNSVQDASSDPAAGLLALLGINVQDVTGQVGLTCNPITVIGGVNSNCDASPVCCENNSFGSLISLGCVPVSL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Hydrophobin, Hydrophobin that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MFSAAISVFVLATLTAATPMARGIIPAPPAGQCNVGTQQCCNSVQDASSDPAAGLLALLGINVQDVTGQVGLTCNPITVIGGVNSNCDASPVCCENNSFGSLISLGCVPVSL" }, { "InterPro": [ { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 33, "End": 110 }, { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 33, "End": 107 } ], "response#1": "MFSAAISVFVLATLTAATPMARGIVPAPPAGQCNVGTQQCCNTVQDASSDPAAGILALLGINVQDVTGQVGLTCNPITVIGGVNSNCDASPVCCENNSFGSLISLGCVPVSL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Hydrophobin, Hydrophobin that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MFSAAISVFVLATLTAATPMARGIVPAPPAGQCNVGTQQCCNTVQDASSDPAAGILALLGINVQDVTGQVGLTCNPITVIGGVNSNCDASPVCCENNSFGSLISLGCVPVSL" }, { "InterPro": [ { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 36, "End": 110 }, { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 36, "End": 107 } ], "response#1": "MFARQATSVSAFLVLTLSLFAAASPLGPAPPTTSQCNVGNQQCCNTVQDSSSAPAAALLGLLGVVLQDVDVLVCSPITVIGGLNSACDASPVCCENNSFGSLISVGCIPISL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Hydrophobin, Hydrophobin that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MFARQATSVSAFLVLTLSLFAAASPLGPAPPTTSQCNVGNQQCCNTVQDSSSAPAAALLGLLGVVLQDVDVLVCSPITVIGGLNSACDASPVCCENNSFGSLISVGCIPISL" }, { "InterPro": [ { "InterPro-ID": "IPR013140", "InterPro-Name": "Huwentoxin_CS1", "InterPro-Type": "CONSERVED_SITE", "Beg": 2, "End": 31 }, { "InterPro-ID": "IPR011696", "InterPro-Name": "Huwentoxin-1", "InterPro-Type": "FAMILY", "Beg": 1, "End": 33 } ], "response#1": "ACLGFGEKCNPSNDKCCKSSSLVCSQKHKWCKYDL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Huwentoxin-1 that shares evolutionary origin and functional similarity; 2. The protein should contain Huwentoxin_CS1 that is preserved across related proteins. The designed protein sequence is ", "reference": "ACLGFGEKCNPSNDKCCKSSSLVCSQKHKWCKYDL" }, { "InterPro": [ { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 49, "End": 123 }, { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 49, "End": 126 } ], "response#1": "MFALRTFAVLFASLSALAAATPLDARTNPTTTVTVTAPASTATVPAGQCNVSNQQCCNSVEKASSGPAALVLGLLGVVVQDVNVLVGLDCSPITVIGGGNGACNASPVCCENNSFGSLISIGCIPISL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Hydrophobin, Hydrophobin that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MFALRTFAVLFASLSALAAATPLDARTNPTTTVTVTAPASTATVPAGQCNVSNQQCCNSVEKASSGPAALVLGLLGVVVQDVNVLVGLDCSPITVIGGGNGACNASPVCCENNSFGSLISIGCIPISL" }, { "InterPro": [ { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 52, "End": 129 }, { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 52, "End": 126 } ], "response#1": "MFARRAISIFAFMLVALSIFAAATPLDARTNPTVTVTVTAPGSTATIPAGQCNVSNQQCCNSVQSASSTPVSVILGLLGIVLQDLNVLVGLTCSPITVIGGGNGGCNANPVCCQNNSFGSLISIGCIPISL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Hydrophobin, Hydrophobin that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MFARRAISIFAFMLVALSIFAAATPLDARTNPTVTVTVTAPGSTATIPAGQCNVSNQQCCNSVQSASSTPVSVILGLLGIVLQDLNVLVGLTCSPITVIGGGNGGCNANPVCCQNNSFGSLISIGCIPISL" }, { "InterPro": [ { "InterPro-ID": "IPR001087", "InterPro-Name": "GDSL", "InterPro-Type": "FAMILY", "Beg": 32, "End": 350 }, { "InterPro-ID": "IPR035669", "InterPro-Name": "SGNH_plant_lipase-like", "InterPro-Type": "FAMILY", "Beg": 31, "End": 355 }, { "InterPro-ID": "IPR036514", "InterPro-Name": "SGNH_hydro_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 25, "End": 357 } ], "response#1": "MGFAARPFHIVFSLFVLAGATQALIICPFDSIYQFGDSISDTGNYIRILPNGPAAAAANFPYGITFPGIPTGRFSDGRLIVDFIARVLGLPLLNPYLQQNASFKNGVNFAVGGATALNSSVLAAAGVQIPDIYLIPLSTQLNWFQTYLRSNCSSPTECSKKVQNSLFLIGNIGNNDVNYALPYRTIQEIEAYVPSIAKAVANATREIIRLGGRRIIVPGTFPFGCLPRNLYLFPNGDKDDLGCLRRLNDLSIYFNNLFQQALNSLRIEFPQAVIIYADYYNAFRFLLRNARALGFTSTLQSCCGIGGPYNFDLNRLCGFPGVPVCRNPREYIQWDGFHYTEAAHRHIVQYLIPDILKELKCS", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to GDSL, SGNH_plant_lipase-like that shares evolutionary origin and functional similarity; 2. The protein should be classified within SGNH_hydro_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MGFAARPFHIVFSLFVLAGATQALIICPFDSIYQFGDSISDTGNYIRILPNGPAAAAANFPYGITFPGIPTGRFSDGRLIVDFIARVLGLPLLNPYLQQNASFKNGVNFAVGGATALNSSVLAAAGVQIPDIYLIPLSTQLNWFQTYLRSNCSSPTECSKKVQNSLFLIGNIGNNDVNYALPYRTIQEIEAYVPSIAKAVANATREIIRLGGRRIIVPGTFPFGCLPRNLYLFPNGDKDDLGCLRRLNDLSIYFNNLFQQALNSLRIEFPQAVIIYADYYNAFRFLLRNARALGFTSTLQSCCGIGGPYNFDLNRLCGFPGVPVCRNPREYIQWDGFHYTEAAHRHIVQYLIPDILKELKCS" }, { "InterPro": [ { "InterPro-ID": "IPR007219", "InterPro-Name": "Transcription_factor_dom_fun", "InterPro-Type": "DOMAIN", "Beg": 392, "End": 474 }, { "InterPro-ID": "IPR001138", "InterPro-Name": "Zn2Cys6_DnaBD", "InterPro-Type": "DOMAIN", "Beg": 136, "End": 166 }, { "InterPro-ID": "IPR001138", "InterPro-Name": "Zn2Cys6_DnaBD", "InterPro-Type": "DOMAIN", "Beg": 131, "End": 175 }, { "InterPro-ID": "IPR001138", "InterPro-Name": "Zn2Cys6_DnaBD", "InterPro-Type": "DOMAIN", "Beg": 136, "End": 172 }, { "InterPro-ID": "IPR001138", "InterPro-Name": "Zn2Cys6_DnaBD", "InterPro-Type": "DOMAIN", "Beg": 136, "End": 164 }, { "InterPro-ID": "IPR001138", "InterPro-Name": "Zn2Cys6_DnaBD", "InterPro-Type": "DOMAIN", "Beg": 132, "End": 167 }, { "InterPro-ID": "IPR007219", "InterPro-Name": "Transcription_factor_dom_fun", "InterPro-Type": "DOMAIN", "Beg": 291, "End": 540 }, { "InterPro-ID": "IPR050815", "InterPro-Name": "TF_fung", "InterPro-Type": "FAMILY", "Beg": 74, "End": 823 }, { "InterPro-ID": "IPR036864", "InterPro-Name": "Zn2-C6_fun-type_DNA-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 135, "End": 215 }, { "InterPro-ID": "IPR036864", "InterPro-Name": "Zn2-C6_fun-type_DNA-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 127, "End": 174 } ], "response#1": "MDFTQLDDFAFAYYGLPDQSSLVSLVDQTHTFQSPTAFPQHQAMSGLAHSGLPFGTLPTGNRSQSMEGSKAPPDRTSPASNALEDSTTDEFGLASRNRADGTDLGVKPKEDKADATAAWSGLRTKAGKERRRLPLACIACRRKKIRCSGEKPACEHCLCSYIPCVYKVTTRKAGPRTDYMAMLDKRPKRMEERVIKAISKLDEEVASSVTCPVVKSAIPGTVPSSKPTKKRSAEEAFGPDLETWAKVPSEPKIEGDDGSSSLQVQGKEGNKLQQEGTEALPSQEIQEHLAELFFDNICGQSYHLLHKPSYMRKLKNGTLPPVLVLTVCAVAARFTSSPLVNSSRPEFLRGEEWASHARDICTRRYECPNLTILTCLLILGLHEFGTCQGGRSWALSGQAIRMAFALQLHKDLEYDPSGRNGTKTQLSFIDREIRRRIMWACFLMDRFNSFETDRPMFIREDTIELPLPVKEKYFQFDMPAPTEMLDGRVPHPPSPKDGQIADTRENMGVAAFLIRAIALWGRIITYLSQGCKDLDPNPLWEDKSHYMKHLNDIVNLEASLPLSLKYSAENLEVHKTEKTPSQFLLMHLCLQHNILFVSRAAMSARKQHGVHVDFFSEASKRTFNAANRISELLREAEQSGCFVSAPFAGYCAFSSTTVHILGIMSRNPSMKLTAQANLTTNVKYLHKMKKYWGMFHWMVENVRTQYRNVLDAMRAGANVEERATQPSFLQYGDWFNRYPRGLFDAEFMDPATHKRKDSGADGVLEAKPELRSVEEYFTLPTPRRVENKDTIRAAAPKRKQSAKKQTGMPAQPGQHLDSLQIIEPDAVSQEHKFSGGLGLQITGVAGFNPLAASKTQIPDFSTTMSPMSPANMTPFAQHAHTHTFFPPELLAMNFGQGSNGNTDPLDRQLIYGGYLMDASTGLGDGYTWAL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Transcription_factor_dom_fun, Zn2Cys6_DnaBD, Zn2Cys6_DnaBD, Zn2Cys6_DnaBD, Zn2Cys6_DnaBD, Zn2Cys6_DnaBD, Transcription_factor_dom_fun that are essential for its biological function; 2. The protein should belong to TF_fung that shares evolutionary origin and functional similarity; 3. The protein should be classified within Zn2-C6_fun-type_DNA-bd_sf, Zn2-C6_fun-type_DNA-bd_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MDFTQLDDFAFAYYGLPDQSSLVSLVDQTHTFQSPTAFPQHQAMSGLAHSGLPFGTLPTGNRSQSMEGSKAPPDRTSPASNALEDSTTDEFGLASRNRADGTDLGVKPKEDKADATAAWSGLRTKAGKERRRLPLACIACRRKKIRCSGEKPACEHCLCSYIPCVYKVTTRKAGPRTDYMAMLDKRPKRMEERVIKAISKLDEEVASSVTCPVVKSAIPGTVPSSKPTKKRSAEEAFGPDLETWAKVPSEPKIEGDDGSSSLQVQGKEGNKLQQEGTEALPSQEIQEHLAELFFDNICGQSYHLLHKPSYMRKLKNGTLPPVLVLTVCAVAARFTSSPLVNSSRPEFLRGEEWASHARDICTRRYECPNLTILTCLLILGLHEFGTCQGGRSWALSGQAIRMAFALQLHKDLEYDPSGRNGTKTQLSFIDREIRRRIMWACFLMDRFNSFETDRPMFIREDTIELPLPVKEKYFQFDMPAPTEMLDGRVPHPPSPKDGQIADTRENMGVAAFLIRAIALWGRIITYLSQGCKDLDPNPLWEDKSHYMKHLNDIVNLEASLPLSLKYSAENLEVHKTEKTPSQFLLMHLCLQHNILFVSRAAMSARKQHGVHVDFFSEASKRTFNAANRISELLREAEQSGCFVSAPFAGYCAFSSTTVHILGIMSRNPSMKLTAQANLTTNVKYLHKMKKYWGMFHWMVENVRTQYRNVLDAMRAGANVEERATQPSFLQYGDWFNRYPRGLFDAEFMDPATHKRKDSGADGVLEAKPELRSVEEYFTLPTPRRVENKDTIRAAAPKRKQSAKKQTGMPAQPGQHLDSLQIIEPDAVSQEHKFSGGLGLQITGVAGFNPLAASKTQIPDFSTTMSPMSPANMTPFAQHAHTHTFFPPELLAMNFGQGSNGNTDPLDRQLIYGGYLMDASTGLGDGYTWAL" }, { "InterPro": [ { "InterPro-ID": "IPR000010", "InterPro-Name": "Cystatin_dom", "InterPro-Type": "DOMAIN", "Beg": 24, "End": 130 }, { "InterPro-ID": "IPR000010", "InterPro-Name": "Cystatin_dom", "InterPro-Type": "DOMAIN", "Beg": 21, "End": 131 }, { "InterPro-ID": "IPR046350", "InterPro-Name": "Cystatin_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 28, "End": 130 }, { "InterPro-ID": "IPR000010", "InterPro-Name": "Cystatin_dom", "InterPro-Type": "DOMAIN", "Beg": 34, "End": 118 }, { "InterPro-ID": "IPR018073", "InterPro-Name": "Prot_inh_cystat_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 70, "End": 83 } ], "response#1": "MTSSLALVLLLGGAAVCAELTLRGGYRERSNHQDDPKYLELAHYATSTWSAQQPGKTHFDTVVEVLKVETQTVAGTNYRLTLKVAESTCELTSTYSKDTCQANANAAHRTCTAVIYENLQGEKSVSSFECAAA", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Cystatin_dom, Cystatin_dom, Cystatin_dom that are essential for its biological function; 2. The protein should be classified within Cystatin_sf sharing conserved structural features; 3. The protein should contain Prot_inh_cystat_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MTSSLALVLLLGGAAVCAELTLRGGYRERSNHQDDPKYLELAHYATSTWSAQQPGKTHFDTVVEVLKVETQTVAGTNYRLTLKVAESTCELTSTYSKDTCQANANAAHRTCTAVIYENLQGEKSVSSFECAAA" }, { "InterPro": [ { "InterPro-ID": "IPR007315", "InterPro-Name": "PIG-V/Gpi18", "InterPro-Type": "FAMILY", "Beg": 2, "End": 494 }, { "InterPro-ID": "IPR007315", "InterPro-Name": "PIG-V/Gpi18", "InterPro-Type": "FAMILY", "Beg": 9, "End": 494 } ], "response#1": "MWSLDPSQKEVLRFAVSCRILTLMLQALFNIIIPDHHADAFSPPRLASSCSVDQLVEGLLGGLSRWDAEHFLFIAEHGYLYEHNFAFFPGFPLALLMGTELLRPLQGLLSQRSCLLVSVALLNFLFSVLAAVTLHDLGCLVLGCPRQAFYAAMLFCLSPANVFLAAGYSEALFAFLTFSAMGQLERGRSWASGLLFALATGVRSNGLVSVGFLLHAQCRGFFSSLVVLNPLKPLFKLMASLCLSVLTVSLPFALFQYYAYTQFCLPGSAHSVPEPLVQLAVDKGYRITGGNEPPWCSWGLPLVYSYIQDVYWNVGFLRYYELRQVPNFLLATPVAVLVVWAAWTYVTTHPWLCLTLGLRRSKDSKKTLEKPHPGFLSPKVFVYLVHAAGLLLFGSLCMHVQVLTRLLCSSTPVVYWFPAHLLQNQEPLLRSVDTVPEKLLEKNSPPGQKAPRNCIMKLLYNWRACSPVTRCILGYFLTYWLLGLLLHCNFLPWT", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to PIG-V/Gpi18, PIG-V/Gpi18 that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MWSLDPSQKEVLRFAVSCRILTLMLQALFNIIIPDHHADAFSPPRLASSCSVDQLVEGLLGGLSRWDAEHFLFIAEHGYLYEHNFAFFPGFPLALLMGTELLRPLQGLLSQRSCLLVSVALLNFLFSVLAAVTLHDLGCLVLGCPRQAFYAAMLFCLSPANVFLAAGYSEALFAFLTFSAMGQLERGRSWASGLLFALATGVRSNGLVSVGFLLHAQCRGFFSSLVVLNPLKPLFKLMASLCLSVLTVSLPFALFQYYAYTQFCLPGSAHSVPEPLVQLAVDKGYRITGGNEPPWCSWGLPLVYSYIQDVYWNVGFLRYYELRQVPNFLLATPVAVLVVWAAWTYVTTHPWLCLTLGLRRSKDSKKTLEKPHPGFLSPKVFVYLVHAAGLLLFGSLCMHVQVLTRLLCSSTPVVYWFPAHLLQNQEPLLRSVDTVPEKLLEKNSPPGQKAPRNCIMKLLYNWRACSPVTRCILGYFLTYWLLGLLLHCNFLPWT" }, { "InterPro": [ { "InterPro-ID": "IPR011989", "InterPro-Name": "ARM-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 219, "End": 422 }, { "InterPro-ID": "IPR016024", "InterPro-Name": "ARM-type_fold", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 12, "End": 418 }, { "InterPro-ID": "IPR056282", "InterPro-Name": "MROH2B-like_N_HEAT", "InterPro-Type": "DOMAIN", "Beg": 79, "End": 250 }, { "InterPro-ID": "IPR011989", "InterPro-Name": "ARM-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1262, "End": 1640 }, { "InterPro-ID": "IPR055406", "InterPro-Name": "HEAT_Maestro", "InterPro-Type": "DOMAIN", "Beg": 1373, "End": 1635 }, { "InterPro-ID": "IPR016024", "InterPro-Name": "ARM-type_fold", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 660, "End": 1639 }, { "InterPro-ID": "IPR021133", "InterPro-Name": "HEAT_type_2", "InterPro-Type": "REPEAT", "Beg": 1610, "End": 1640 }, { "InterPro-ID": "IPR045206", "InterPro-Name": "Maestro_heat-like_prot", "InterPro-Type": "FAMILY", "Beg": 75, "End": 1639 }, { "InterPro-ID": "IPR048465", "InterPro-Name": "Maestro-like_HEAT", "InterPro-Type": "DOMAIN", "Beg": 933, "End": 1162 }, { "InterPro-ID": "IPR055408", "InterPro-Name": "HEAT_MROH2B-like", "InterPro-Type": "DOMAIN", "Beg": 254, "End": 908 } ], "response#1": "MTRPYIKRLSFTLLDSITDKDPMVQEQVCSALCSLGDAQPDETLHACEEYLRQHDKLAHPYRTKILRAMETVLSSHIHDLDKDTAGAVILLATSEMTRTKELDCDWQQAAGSVLVAVGKRFTNQVMEEVLSRFQPGMLPHSSVLHTLANLSVSNAFDMVPFLPSILSTMLPMLSMAKQDALKVVFCGALQHFSESILEYLANLDQAPDPTVRKDTFGADIFGAYDVLFHHWLQSRDAKLRLAVVAALGPMSHLLPSERLEEQLPKLLPAVLGLYKKHAEAFQISKSLGQILEAAVNVSSRTLEVQLDALLVALHAQICVPVESSSPLVMNSQKEVLRCFTVLACCSPDRLLAFLLPRLDTSNERLRVGTLQILRHIINSAAAQMEAKQPFILSSMRLPLLDTNDKVKRAVVQVISAMAHHGYLEQPGGEVMVEYIVQQCALPAEEPEKPGPDGEDLAADSVRAVSIRTLYLVSTTVDRMNSVLWPYLLEFLTPVRFTAALTPLCRSLVHLALKRQEAGADDFLIQYNANANLPSPFAMTTRLLVVSSNPYLGDGRGAASLRLLKVMHQNIHPFLGQRWETTMPMLLEYLDEHTEESLSLKEWEEKLLMFLRDTLAVVSDNIWICQLSQEMCKQLPSYSGTPQEKNFLYKCIGTTLGAASSKEVVRKHLRELLETARYQEEAEQEGLACCFGICAITHLEDTLAQLEDFVRSDVFRKSTGIFSIFKDRSEHEVERMKSCLILCYGHVAAQAPRELVLARVESDILRSMFQCFNTKVLGIKVETKDPALKLCLVQSLCMVSQAMCSSAQASSFHFLRKTELVTQMMEFIRAEPPDCLRTPIRKKAMLACTYLVNLEPALEEQTQADVVHSCLHSVMALPPEAEGGDGVGREPLYLDTVCALEDLLTRLLRQNMTPQGLQIMVEHLSPWIKSPRGHERARALGLGACLLEFFQEHLLVSTLVPFHNLGLLVGLFAPRCADTWTTTRQKAVGCVYSLLYLQLGYEGFSRDHRDDVAERLLTLQDGLVNADPTILFHTCHSIAQVIAKRLPSDQLISLLLTVFESLGDPDKNCSRAATVMINCLLKERGNVLLEKVPEIVSVLRAKLRDTQEEHVLPAAQHSVYLLASQHCEAVVSSLLGSPLPFDSHTCALWRALAVEPGLTAQVLELLLEKMSKDVPFKESRAFLLGSTADRVATLLPLAATCALYEVLSAPSSGTVVLELYPQLFAALLLRVSCTVGVQLPRNLQAKERRSTSPARAARNLDPCSSAVDALQALLLRSGSQDMLRCVELERGWELLKTSAGHEDGVAQLASSMAKYAGPRLPPVTKALACTQNSVYEIQRVTSTAFLAELLSSNVVNDLMLLEPLLDNLTARLKDSSASVRRLVLRGLANMASGSPDKVRAHGPQLLTAMVSGLDDGDEPHSPVALEAMVGLSRLLDLVEPWDLRLVLLHTTIRIRPFFDSEKVEFRTASIRLFGHLNKACHGDCEDVFLEQVVGGLVPLLLHLRDPQVPVASACKFALCMCVPHLECAELAAAFYKYLQEGRSVHFGEFLNSTCKHLMHHFPDLLGRLVSTNLFYFKSSWDDVRAAAPMFTGFLVLHAEPEQKTQVDLEQLIVALQLLLKDPVPGVREKAAETLGRLVKFA", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more MROH2B-like_N_HEAT, HEAT_Maestro, Maestro-like_HEAT, HEAT_MROH2B-like that are essential for its biological function; 2. The protein should belong to Maestro_heat-like_prot that shares evolutionary origin and functional similarity; 3. The protein should be classified within ARM-like, ARM-type_fold, ARM-like, ARM-type_fold sharing conserved structural features; 4. The protein should include one or more HEAT_type_2 that provide structural or functional support. The designed protein sequence is ", "reference": "MTRPYIKRLSFTLLDSITDKDPMVQEQVCSALCSLGDAQPDETLHACEEYLRQHDKLAHPYRTKILRAMETVLSSHIHDLDKDTAGAVILLATSEMTRTKELDCDWQQAAGSVLVAVGKRFTNQVMEEVLSRFQPGMLPHSSVLHTLANLSVSNAFDMVPFLPSILSTMLPMLSMAKQDALKVVFCGALQHFSESILEYLANLDQAPDPTVRKDTFGADIFGAYDVLFHHWLQSRDAKLRLAVVAALGPMSHLLPSERLEEQLPKLLPAVLGLYKKHAEAFQISKSLGQILEAAVNVSSRTLEVQLDALLVALHAQICVPVESSSPLVMNSQKEVLRCFTVLACCSPDRLLAFLLPRLDTSNERLRVGTLQILRHIINSAAAQMEAKQPFILSSMRLPLLDTNDKVKRAVVQVISAMAHHGYLEQPGGEVMVEYIVQQCALPAEEPEKPGPDGEDLAADSVRAVSIRTLYLVSTTVDRMNSVLWPYLLEFLTPVRFTAALTPLCRSLVHLALKRQEAGADDFLIQYNANANLPSPFAMTTRLLVVSSNPYLGDGRGAASLRLLKVMHQNIHPFLGQRWETTMPMLLEYLDEHTEESLSLKEWEEKLLMFLRDTLAVVSDNIWICQLSQEMCKQLPSYSGTPQEKNFLYKCIGTTLGAASSKEVVRKHLRELLETARYQEEAEQEGLACCFGICAITHLEDTLAQLEDFVRSDVFRKSTGIFSIFKDRSEHEVERMKSCLILCYGHVAAQAPRELVLARVESDILRSMFQCFNTKVLGIKVETKDPALKLCLVQSLCMVSQAMCSSAQASSFHFLRKTELVTQMMEFIRAEPPDCLRTPIRKKAMLACTYLVNLEPALEEQTQADVVHSCLHSVMALPPEAEGGDGVGREPLYLDTVCALEDLLTRLLRQNMTPQGLQIMVEHLSPWIKSPRGHERARALGLGACLLEFFQEHLLVSTLVPFHNLGLLVGLFAPRCADTWTTTRQKAVGCVYSLLYLQLGYEGFSRDHRDDVAERLLTLQDGLVNADPTILFHTCHSIAQVIAKRLPSDQLISLLLTVFESLGDPDKNCSRAATVMINCLLKERGNVLLEKVPEIVSVLRAKLRDTQEEHVLPAAQHSVYLLASQHCEAVVSSLLGSPLPFDSHTCALWRALAVEPGLTAQVLELLLEKMSKDVPFKESRAFLLGSTADRVATLLPLAATCALYEVLSAPSSGTVVLELYPQLFAALLLRVSCTVGVQLPRNLQAKERRSTSPARAARNLDPCSSAVDALQALLLRSGSQDMLRCVELERGWELLKTSAGHEDGVAQLASSMAKYAGPRLPPVTKALACTQNSVYEIQRVTSTAFLAELLSSNVVNDLMLLEPLLDNLTARLKDSSASVRRLVLRGLANMASGSPDKVRAHGPQLLTAMVSGLDDGDEPHSPVALEAMVGLSRLLDLVEPWDLRLVLLHTTIRIRPFFDSEKVEFRTASIRLFGHLNKACHGDCEDVFLEQVVGGLVPLLLHLRDPQVPVASACKFALCMCVPHLECAELAAAFYKYLQEGRSVHFGEFLNSTCKHLMHHFPDLLGRLVSTNLFYFKSSWDDVRAAAPMFTGFLVLHAEPEQKTQVDLEQLIVALQLLLKDPVPGVREKAAETLGRLVKFA" }, { "InterPro": [ { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 33, "End": 107 }, { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 33, "End": 110 }, { "InterPro-ID": "IPR019778", "InterPro-Name": "Hydrophobin_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 84, "End": 95 } ], "response#1": "MRFFATLVLALPALAMATAVPRDVNGGTPPKSCSSGPVYCCNKTEDHLDKGTTALLGLLNIKIGDLKDLVGLNCSPLSVIGVGGNSCSAQTVCCTNTYQHGLVNVGCTPINIGL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Hydrophobin, Hydrophobin that shares evolutionary origin and functional similarity; 2. The protein should contain Hydrophobin_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MRFFATLVLALPALAMATAVPRDVNGGTPPKSCSSGPVYCCNKTEDHLDKGTTALLGLLNIKIGDLKDLVGLNCSPLSVIGVGGNSCSAQTVCCTNTYQHGLVNVGCTPINIGL" }, { "InterPro": [ { "InterPro-ID": "IPR023213", "InterPro-Name": "CAT-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 214, "End": 435 }, { "InterPro-ID": "IPR023213", "InterPro-Name": "CAT-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1, "End": 204 } ], "response#1": "MNITILSKETIKPLAPTPHHHKYYKVSLLDQFAPSSYMPFIFFYPNKFADRDAAGILTQLKESLSQILTIYYPLAGRVKDTVYVECNDEGVEFIEAQANGSLSDFLKQPDIAALNNFLPRNGNGLEKGCSISPVAIKATVFECSGIVLGVCIFHKVVDAAAAGEFLQSWAKIGRGSKETVELPNFTSASSLFPPRESLSSKFVRDFDNFFFQGSKSFMRRFVFDATAITTLRTKATSEKVPNPSRVEALMEFVVQHLSTAFKTAKSETPETLMITHPVNLRKRIEPPLPDSTFGNVIWLAFAFYDCDPSETKIKPGDVVERVREAFAALDKESISELETDDAFTSLSELLESVYTNEKIKIYRFTSTCNMGFYDVDFGWGKPVWVAHMGNMVDYRCKQQIVFMETGHMSKDIELWLAAEEDELSVLEKNAEFLAYATPNPTIWLDSDGTN", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should be classified within CAT-like_dom_sf, CAT-like_dom_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MNITILSKETIKPLAPTPHHHKYYKVSLLDQFAPSSYMPFIFFYPNKFADRDAAGILTQLKESLSQILTIYYPLAGRVKDTVYVECNDEGVEFIEAQANGSLSDFLKQPDIAALNNFLPRNGNGLEKGCSISPVAIKATVFECSGIVLGVCIFHKVVDAAAAGEFLQSWAKIGRGSKETVELPNFTSASSLFPPRESLSSKFVRDFDNFFFQGSKSFMRRFVFDATAITTLRTKATSEKVPNPSRVEALMEFVVQHLSTAFKTAKSETPETLMITHPVNLRKRIEPPLPDSTFGNVIWLAFAFYDCDPSETKIKPGDVVERVREAFAALDKESISELETDDAFTSLSELLESVYTNEKIKIYRFTSTCNMGFYDVDFGWGKPVWVAHMGNMVDYRCKQQIVFMETGHMSKDIELWLAAEEDELSVLEKNAEFLAYATPNPTIWLDSDGTN" }, { "InterPro": [ { "InterPro-ID": "IPR044497", "InterPro-Name": "AKR4A/B", "InterPro-Type": "FAMILY", "Beg": 14, "End": 296 }, { "InterPro-ID": "IPR020471", "InterPro-Name": "AKR", "InterPro-Type": "FAMILY", "Beg": 3, "End": 313 }, { "InterPro-ID": "IPR020471", "InterPro-Name": "AKR", "InterPro-Type": "FAMILY", "Beg": 10, "End": 296 }, { "InterPro-ID": "IPR023210", "InterPro-Name": "NADP_OxRdtase_dom", "InterPro-Type": "DOMAIN", "Beg": 35, "End": 294 }, { "InterPro-ID": "IPR036812", "InterPro-Name": "NADP_OxRdtase_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 7, "End": 323 }, { "InterPro-ID": "IPR018170", "InterPro-Name": "Aldo/ket_reductase_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 152, "End": 169 }, { "InterPro-ID": "IPR020471", "InterPro-Name": "AKR", "InterPro-Type": "FAMILY", "Beg": 105, "End": 123 }, { "InterPro-ID": "IPR020471", "InterPro-Name": "AKR", "InterPro-Type": "FAMILY", "Beg": 152, "End": 169 }, { "InterPro-ID": "IPR020471", "InterPro-Name": "AKR", "InterPro-Type": "FAMILY", "Beg": 44, "End": 68 }, { "InterPro-ID": "IPR020471", "InterPro-Name": "AKR", "InterPro-Type": "FAMILY", "Beg": 230, "End": 254 }, { "InterPro-ID": "IPR020471", "InterPro-Name": "AKR", "InterPro-Type": "FAMILY", "Beg": 186, "End": 215 }, { "InterPro-ID": "IPR036812", "InterPro-Name": "NADP_OxRdtase_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 11, "End": 302 }, { "InterPro-ID": "IPR018170", "InterPro-Name": "Aldo/ket_reductase_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 48, "End": 65 } ], "response#1": "MEKQVQIPEIELNSGHKMPLVGFGTCVPDPIPPLEELAGIFLEAIKVGYRHFDTASSYGTEEALGRAVAQAIETGLVNGREEFFISSKLWCEDADLDLILPALKKTLGNMGLDYLDLSMIHMPVRVRKGAEMFNYTKEDLLPFDIQGTWKAMEECNKLGLAKSIGVSNYSCEKLTKLLENATVPPAVNQVEMNVVWQQRKLLPFCKEKNIHVTAWSPLLSYGAVWGSNAVMENPILVEIAASKNKTVAQVALRWIYEQGASFIMRTFNKDRMFENVQIFDWELTKEELDKIQKIPQRRGTLGEDFIHPEGPIKSVEDLWDGDL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more NADP_OxRdtase_dom that are essential for its biological function; 2. The protein should belong to AKR4A/B, AKR, AKR, AKR, AKR, AKR, AKR, AKR that shares evolutionary origin and functional similarity; 3. The protein should be classified within NADP_OxRdtase_dom_sf, NADP_OxRdtase_dom_sf sharing conserved structural features; 4. The protein should contain Aldo/ket_reductase_CS, Aldo/ket_reductase_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MEKQVQIPEIELNSGHKMPLVGFGTCVPDPIPPLEELAGIFLEAIKVGYRHFDTASSYGTEEALGRAVAQAIETGLVNGREEFFISSKLWCEDADLDLILPALKKTLGNMGLDYLDLSMIHMPVRVRKGAEMFNYTKEDLLPFDIQGTWKAMEECNKLGLAKSIGVSNYSCEKLTKLLENATVPPAVNQVEMNVVWQQRKLLPFCKEKNIHVTAWSPLLSYGAVWGSNAVMENPILVEIAASKNKTVAQVALRWIYEQGASFIMRTFNKDRMFENVQIFDWELTKEELDKIQKIPQRRGTLGEDFIHPEGPIKSVEDLWDGDL" }, { "InterPro": [ { "InterPro-ID": "IPR020471", "InterPro-Name": "AKR", "InterPro-Type": "FAMILY", "Beg": 3, "End": 314 }, { "InterPro-ID": "IPR036812", "InterPro-Name": "NADP_OxRdtase_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 7, "End": 323 }, { "InterPro-ID": "IPR020471", "InterPro-Name": "AKR", "InterPro-Type": "FAMILY", "Beg": 10, "End": 297 }, { "InterPro-ID": "IPR036812", "InterPro-Name": "NADP_OxRdtase_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 11, "End": 298 }, { "InterPro-ID": "IPR018170", "InterPro-Name": "Aldo/ket_reductase_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 152, "End": 169 }, { "InterPro-ID": "IPR020471", "InterPro-Name": "AKR", "InterPro-Type": "FAMILY", "Beg": 152, "End": 169 }, { "InterPro-ID": "IPR020471", "InterPro-Name": "AKR", "InterPro-Type": "FAMILY", "Beg": 230, "End": 254 }, { "InterPro-ID": "IPR020471", "InterPro-Name": "AKR", "InterPro-Type": "FAMILY", "Beg": 105, "End": 123 }, { "InterPro-ID": "IPR020471", "InterPro-Name": "AKR", "InterPro-Type": "FAMILY", "Beg": 44, "End": 68 }, { "InterPro-ID": "IPR020471", "InterPro-Name": "AKR", "InterPro-Type": "FAMILY", "Beg": 186, "End": 215 }, { "InterPro-ID": "IPR023210", "InterPro-Name": "NADP_OxRdtase_dom", "InterPro-Type": "DOMAIN", "Beg": 35, "End": 294 }, { "InterPro-ID": "IPR018170", "InterPro-Name": "Aldo/ket_reductase_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 48, "End": 65 } ], "response#1": "MEKQVQMPEVELNSDHKMPLVGFGTCIPDPIPPLEELATIFLEVIKVGYRHFDTASCYGTEEALGKAVAQAIESGLVNGREEFFITSKLWVEDADQDLILPALKKTLGNLGLDYLDLYLIHMPLRLRQGAEMFKYTKEDFLPFDIKGTWKAMEECSKLGLCKSIGVSNYSCEKLSKLLENATILPAVNQVEMNVVWKQSKLLPFCKEKNIHVSAWSPLLSYGSIWSQNAVMENTVLVDIAASKSKTVAQVALRWIYEQGASFIMRTFNKERMYQNVQIFDWELTQEELDQIQQIPQRRSNLAEAFVHPEGPIKSVEELWDGDL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more NADP_OxRdtase_dom that are essential for its biological function; 2. The protein should belong to AKR, AKR, AKR, AKR, AKR, AKR, AKR that shares evolutionary origin and functional similarity; 3. The protein should be classified within NADP_OxRdtase_dom_sf, NADP_OxRdtase_dom_sf sharing conserved structural features; 4. The protein should contain Aldo/ket_reductase_CS, Aldo/ket_reductase_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MEKQVQMPEVELNSDHKMPLVGFGTCIPDPIPPLEELATIFLEVIKVGYRHFDTASCYGTEEALGKAVAQAIESGLVNGREEFFITSKLWVEDADQDLILPALKKTLGNLGLDYLDLYLIHMPLRLRQGAEMFKYTKEDFLPFDIKGTWKAMEECSKLGLCKSIGVSNYSCEKLSKLLENATILPAVNQVEMNVVWKQSKLLPFCKEKNIHVSAWSPLLSYGSIWSQNAVMENTVLVDIAASKSKTVAQVALRWIYEQGASFIMRTFNKERMYQNVQIFDWELTQEELDQIQQIPQRRSNLAEAFVHPEGPIKSVEELWDGDL" }, { "InterPro": [ { "InterPro-ID": "IPR023213", "InterPro-Name": "CAT-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 201, "End": 411 }, { "InterPro-ID": "IPR023213", "InterPro-Name": "CAT-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 5, "End": 194 } ], "response#1": "MAPILQRISKTFIKPSSPTPESLRCYNLSSSDQMITSVYISLAFFYGSPGCESSRIRQQLDNSLSRTLVYYYPFAGRLVDNDHIDCNDQGVQFVEVRIHCPISAILKQTTSYAEDLVFPRGTSACHEDSLVVVQLNRFECGGVAIAVCISHKVADGSGAIAFINDWAATARVSSHIPSPLLVADSIFPHLDNSLPVPYNLSKNCVTRRFVFPAAEIEKLKSKAVESGLQQPTRVEVVTALLYQCALLASRSTNSGLSRPSVLIQAVNLRPFLVPPLPRNSVGNIFSINFSIIEVDSLEFPELAGRLRKAKLKFQNLSQEKLYYDSQMQELGECLKQLNTGNFDVYYCSSWCRFPVYDVDFGWGKPTWVCTVKSQIKDMIVLMDSPGDEIAAFVTLEEEKMSAFQHNELLLSFASLYSAK", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should be classified within CAT-like_dom_sf, CAT-like_dom_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MAPILQRISKTFIKPSSPTPESLRCYNLSSSDQMITSVYISLAFFYGSPGCESSRIRQQLDNSLSRTLVYYYPFAGRLVDNDHIDCNDQGVQFVEVRIHCPISAILKQTTSYAEDLVFPRGTSACHEDSLVVVQLNRFECGGVAIAVCISHKVADGSGAIAFINDWAATARVSSHIPSPLLVADSIFPHLDNSLPVPYNLSKNCVTRRFVFPAAEIEKLKSKAVESGLQQPTRVEVVTALLYQCALLASRSTNSGLSRPSVLIQAVNLRPFLVPPLPRNSVGNIFSINFSIIEVDSLEFPELAGRLRKAKLKFQNLSQEKLYYDSQMQELGECLKQLNTGNFDVYYCSSWCRFPVYDVDFGWGKPTWVCTVKSQIKDMIVLMDSPGDEIAAFVTLEEEKMSAFQHNELLLSFASLYSAK" }, { "InterPro": [ { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 65, "End": 140 }, { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 65, "End": 143 } ], "response#1": "MKFSYAIAAVVAAAASVQAVETNGQRMARGLKPLPPRNIHRRASRTNEARGATPSGTPSGGDYNCNTGSVQCCNQVSKANDTVISAILGLLGIGGVADDVLVGLKCSPLSVVGLGSGNSCSQRPVCCENNSKGGLVSIGCIPITL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Hydrophobin, Hydrophobin that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MKFSYAIAAVVAAAASVQAVETNGQRMARGLKPLPPRNIHRRASRTNEARGATPSGTPSGGDYNCNTGSVQCCNQVSKANDTVISAILGLLGIGGVADDVLVGLKCSPLSVVGLGSGNSCSQRPVCCENNSKGGLVSIGCIPITL" }, { "InterPro": [ { "InterPro-ID": "IPR004897", "InterPro-Name": "P/V_Pprotein_paramyxoviral", "InterPro-Type": "FAMILY", "Beg": 235, "End": 387 } ], "response#1": "MDQFIKQDETGDLIETGMNVANHFLSTPIQGTNSLSKASILPGVAPVLIGNPEQKNIQHPTASHQGSKTKGRGSGVRSIIVSPSEAGNGGTQIPEPLFAQTGQGGIVTTVYQDPTIQPTGSYRSVELAKIGKERMINRFVEKPRTSTPVTEFKRGGPGAAAQGQTIQEEGIDGNGASAGSKERSGSLSGATLYAHLSLPQQDSTPANVGIAPQSAISANEIMDLLRGMDARLQHLEQKVDKVLAQGSMVTQIKNELSTVKTTLATIEGMMATVKIMDPGNPTGVPVDELRRSFSDHVTIVSGPGDVSFSSSEKPTLYLDELARPVSKPRPAKQTKSQPVKDLAGQKVMITKMITDCVANPQMKQAFEQRLAKASTEDALNDIKRDIIRSAI", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to P/V_Pprotein_paramyxoviral that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MDQFIKQDETGDLIETGMNVANHFLSTPIQGTNSLSKASILPGVAPVLIGNPEQKNIQHPTASHQGSKTKGRGSGVRSIIVSPSEAGNGGTQIPEPLFAQTGQGGIVTTVYQDPTIQPTGSYRSVELAKIGKERMINRFVEKPRTSTPVTEFKRGGPGAAAQGQTIQEEGIDGNGASAGSKERSGSLSGATLYAHLSLPQQDSTPANVGIAPQSAISANEIMDLLRGMDARLQHLEQKVDKVLAQGSMVTQIKNELSTVKTTLATIEGMMATVKIMDPGNPTGVPVDELRRSFSDHVTIVSGPGDVSFSSSEKPTLYLDELARPVSKPRPAKQTKSQPVKDLAGQKVMITKMITDCVANPQMKQAFEQRLAKASTEDALNDIKRDIIRSAI" }, { "InterPro": [ { "InterPro-ID": "IPR029063", "InterPro-Name": "SAM-dependent_MTases_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 115, "End": 362 }, { "InterPro-ID": "IPR029063", "InterPro-Name": "SAM-dependent_MTases_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 120, "End": 353 }, { "InterPro-ID": "IPR036390", "InterPro-Name": "WH_DNA-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 15, "End": 118 }, { "InterPro-ID": "IPR036388", "InterPro-Name": "WH-like_DNA-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 3, "End": 114 }, { "InterPro-ID": "IPR016461", "InterPro-Name": "COMT-like", "InterPro-Type": "FAMILY", "Beg": 1, "End": 362 }, { "InterPro-ID": "IPR001077", "InterPro-Name": "O_MeTrfase_dom", "InterPro-Type": "DOMAIN", "Beg": 139, "End": 344 }, { "InterPro-ID": "IPR012967", "InterPro-Name": "Plant_O-MeTrfase_dimerisation", "InterPro-Type": "DOMAIN", "Beg": 15, "End": 116 }, { "InterPro-ID": "IPR016461", "InterPro-Name": "COMT-like", "InterPro-Type": "FAMILY", "Beg": 21, "End": 344 }, { "InterPro-ID": "IPR016461", "InterPro-Name": "COMT-like", "InterPro-Type": "FAMILY", "Beg": 23, "End": 362 } ], "response#1": "MGSASGSAERTQMGEDEACSFAMTITSGSVPPMVLKAVIELDVLEIIKRAGPGAHLSPAEIAAQLPTTNPGAAAMLDRMLRLLASYDVLSYSLHTLPDGRVERLYGLAPVCQFLTNNEDGVTLSALSLMNQDKVLMESWYHLKDAVLDGGIPFNKAYGMTAFEYHGTDPRFNKVFNNGMSNHSTITMKKLLENYKGFEGVSTLVDVGGGTGATLNMIISKHPTIKGINFDLPHVIEDAPTYPGVEHIGGDMFVSVPKGDAIFMKWICHDWSDEHCLRFLKNCYAALADHGKVIVCEYILPVAPETNHAARTVFHVDAIMLAHNPGGKERTEQEFESLAKGAGFEGFRVACSAYDTKVMEFLKNN", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more O_MeTrfase_dom, Plant_O-MeTrfase_dimerisation that are essential for its biological function; 2. The protein should belong to COMT-like, COMT-like, COMT-like that shares evolutionary origin and functional similarity; 3. The protein should be classified within SAM-dependent_MTases_sf, SAM-dependent_MTases_sf, WH_DNA-bd_sf, WH-like_DNA-bd_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MGSASGSAERTQMGEDEACSFAMTITSGSVPPMVLKAVIELDVLEIIKRAGPGAHLSPAEIAAQLPTTNPGAAAMLDRMLRLLASYDVLSYSLHTLPDGRVERLYGLAPVCQFLTNNEDGVTLSALSLMNQDKVLMESWYHLKDAVLDGGIPFNKAYGMTAFEYHGTDPRFNKVFNNGMSNHSTITMKKLLENYKGFEGVSTLVDVGGGTGATLNMIISKHPTIKGINFDLPHVIEDAPTYPGVEHIGGDMFVSVPKGDAIFMKWICHDWSDEHCLRFLKNCYAALADHGKVIVCEYILPVAPETNHAARTVFHVDAIMLAHNPGGKERTEQEFESLAKGAGFEGFRVACSAYDTKVMEFLKNN" }, { "InterPro": [ { "InterPro-ID": "IPR016461", "InterPro-Name": "COMT-like", "InterPro-Type": "FAMILY", "Beg": 11, "End": 374 }, { "InterPro-ID": "IPR036388", "InterPro-Name": "WH-like_DNA-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 17, "End": 125 }, { "InterPro-ID": "IPR016461", "InterPro-Name": "COMT-like", "InterPro-Type": "FAMILY", "Beg": 34, "End": 374 }, { "InterPro-ID": "IPR001077", "InterPro-Name": "O_MeTrfase_dom", "InterPro-Type": "DOMAIN", "Beg": 151, "End": 356 }, { "InterPro-ID": "IPR016461", "InterPro-Name": "COMT-like", "InterPro-Type": "FAMILY", "Beg": 34, "End": 355 }, { "InterPro-ID": "IPR029063", "InterPro-Name": "SAM-dependent_MTases_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 131, "End": 372 }, { "InterPro-ID": "IPR029063", "InterPro-Name": "SAM-dependent_MTases_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 128, "End": 374 }, { "InterPro-ID": "IPR012967", "InterPro-Name": "Plant_O-MeTrfase_dimerisation", "InterPro-Type": "DOMAIN", "Beg": 26, "End": 128 }, { "InterPro-ID": "IPR036390", "InterPro-Name": "WH_DNA-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 26, "End": 131 } ], "response#1": "MAPNNVDNPQNCVVNNTINGGVGVDDEETYGYAAQVLNSCVLPMVLNATIELGVLHLVNQAGSGPDGLSPAQLAALIQARNPDASVMLDRMLRVLATYDVVSCTAVPTEDGGFERRYGPAPVTKCFVPDEDGVSLAPMLNLVIDKVFLQSWSKLKEAVMEGGIPFNKVHGMHAFEYPAVDPRFNEIFNKAMYDQSTHIIKNILAKYKGFSQIQQLVDVGGGLGHTLRVITSKYPSIKGINFDLPHVVEHAPQIPGVEHVGGDMFESVPKGDAIFMKWILHDWSDDKCLTLLKNCYKALPENGMVIAVETNITDQPETTAYARAISQLDVSMMTQNPGGKERTRREFESLAKSAGFARVDFVCCASSFWVMEFHK", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more O_MeTrfase_dom, Plant_O-MeTrfase_dimerisation that are essential for its biological function; 2. The protein should belong to COMT-like, COMT-like, COMT-like that shares evolutionary origin and functional similarity; 3. The protein should be classified within WH-like_DNA-bd_sf, SAM-dependent_MTases_sf, SAM-dependent_MTases_sf, WH_DNA-bd_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MAPNNVDNPQNCVVNNTINGGVGVDDEETYGYAAQVLNSCVLPMVLNATIELGVLHLVNQAGSGPDGLSPAQLAALIQARNPDASVMLDRMLRVLATYDVVSCTAVPTEDGGFERRYGPAPVTKCFVPDEDGVSLAPMLNLVIDKVFLQSWSKLKEAVMEGGIPFNKVHGMHAFEYPAVDPRFNEIFNKAMYDQSTHIIKNILAKYKGFSQIQQLVDVGGGLGHTLRVITSKYPSIKGINFDLPHVVEHAPQIPGVEHVGGDMFESVPKGDAIFMKWILHDWSDDKCLTLLKNCYKALPENGMVIAVETNITDQPETTAYARAISQLDVSMMTQNPGGKERTRREFESLAKSAGFARVDFVCCASSFWVMEFHK" }, { "InterPro": [ { "InterPro-ID": "IPR051368", "InterPro-Name": "SerProtInhib-TIL_Domain", "InterPro-Type": "FAMILY", "Beg": 25, "End": 91 }, { "InterPro-ID": "IPR002919", "InterPro-Name": "TIL_dom", "InterPro-Type": "DOMAIN", "Beg": 34, "End": 90 }, { "InterPro-ID": "IPR036084", "InterPro-Name": "Ser_inhib-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 31, "End": 91 } ], "response#1": "MKTYVLQALLLTLAVAVVRAANTGIEWPPKPQKCAEGETWKECVGSSCAELTCEHPEPSLGCTYDCNYGCYCAPDFFRNANKECVKKDKCP", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more TIL_dom that are essential for its biological function; 2. The protein should belong to SerProtInhib-TIL_Domain that shares evolutionary origin and functional similarity; 3. The protein should be classified within Ser_inhib-like_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MKTYVLQALLLTLAVAVVRAANTGIEWPPKPQKCAEGETWKECVGSSCAELTCEHPEPSLGCTYDCNYGCYCAPDFFRNANKECVKKDKCP" }, { "InterPro": [ { "InterPro-ID": "IPR023213", "InterPro-Name": "CAT-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 4, "End": 203 }, { "InterPro-ID": "IPR023213", "InterPro-Name": "CAT-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 238, "End": 452 } ], "response#1": "MEPSKMEVKIISSETIKPSSPTPSHLRKYTLSLLDQKYTPIVVPAILFYERPQGVAPLDMDRLRTCLSQTLTAFYPLAGRAESRDVIICNDEGIPFVEAHVDCELSSVVKSLSSLGSDLRSFYPPRDGLLEGGIQFAIQMNVFSCGGFAFAWYCTHNVTDGTSTANFFRYWTALYAQRSEYAVQDLMDFNSVVTAFPPVPPRVPQEEKPVTTELKPEKQEGQEKEEKKKSSFNFSFQSHIVARSFLIKSKAVAELKAKSVSEEVPYPSRFEAVSAFLWKSIVSSSTTEGKTMINMPVNLRPRVDPPLPLDSVGNIFENALVQSEKKAELHEFVARIRGSISKMKDFATEYQGEKREEAKDAHWKRFIKAVIECKGKDAYVISPWYKSSGFTDIDFGFGTPIRVVPMDDVVNHNQRNTIMLMEFVDSDGDGFEAWMFLEEECIKFLESNPEFLAFASPNF", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should be classified within CAT-like_dom_sf, CAT-like_dom_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MEPSKMEVKIISSETIKPSSPTPSHLRKYTLSLLDQKYTPIVVPAILFYERPQGVAPLDMDRLRTCLSQTLTAFYPLAGRAESRDVIICNDEGIPFVEAHVDCELSSVVKSLSSLGSDLRSFYPPRDGLLEGGIQFAIQMNVFSCGGFAFAWYCTHNVTDGTSTANFFRYWTALYAQRSEYAVQDLMDFNSVVTAFPPVPPRVPQEEKPVTTELKPEKQEGQEKEEKKKSSFNFSFQSHIVARSFLIKSKAVAELKAKSVSEEVPYPSRFEAVSAFLWKSIVSSSTTEGKTMINMPVNLRPRVDPPLPLDSVGNIFENALVQSEKKAELHEFVARIRGSISKMKDFATEYQGEKREEAKDAHWKRFIKAVIECKGKDAYVISPWYKSSGFTDIDFGFGTPIRVVPMDDVVNHNQRNTIMLMEFVDSDGDGFEAWMFLEEECIKFLESNPEFLAFASPNF" }, { "InterPro": [ { "InterPro-ID": "IPR027956", "InterPro-Name": "C1orf127-like", "InterPro-Type": "FAMILY", "Beg": 20, "End": 763 }, { "InterPro-ID": "IPR049521", "InterPro-Name": "DUF4556", "InterPro-Type": "DOMAIN", "Beg": 254, "End": 358 } ], "response#1": "MWGSVAVVWAICLACIQPAVFPWILPVRSNKDRPRPAHGALTEKVECFSDYMTLQIPSSHVQGLKQWLVGVLRLPGSKRAPNHLDSLLTKCGYLLHPAHEGGFIFRALYSGCFVQKEKANYRLEIRMFQKGAKRLKQSDRYIMRCPMMVARLGEQSVRCHPSFIQVSRPWPPRTDAGQTPWLLSLRGELVASLEDASLMGLEVDIGATMVTIQSPRQELLQRQEVWNTSLELLPLWLVSGSYAYSFEAACPLVSSQPGSEISVHIPKQRLGLVKRGSLVEESLSPRFLQVQQTDTFTVAEDRDFVIVSIPSMRLLQDQPCQKARESPGTQAFYRVDLSLDFAEMDSPVHWTVENFFQCVGSREDSLFSTVTPRTTLPTQSPGWETTPAETPPAASPPLQTPQMAVLEEPPQHFVHQSAKESTKQELAAAFMQITRPARGSWVSMASPSSSAMQEHQGPQTPPEKADLSPHPQTPATLSSEHTEVSQAGPGPSHYVSLAPNSLSTHLSSEITSSLWPSWPSDGPPMLLSSEPSVKLTEVPRATRAGQDSIQPSRSPFPPGELSRETVNSTESTEPIPREPAYIREEFPPFTKSFMSSLAEEGLIFHPDPKRPQERPIVKAEKPLQNDHGPSGEETRHYLDLSTSEPSQEMKELGVDATFTTSRRRQPDARAYLGTSRPELTGRPRVGTAALQTTLHKGLLASTSERPAAPSEGALQLESAPSWPEGWHDLGAAHTASPLSSHTHSPLVPTQAMFPGSDEPGNSLPGSQGSVESRLLPTTDSHQSPEL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more DUF4556 that are essential for its biological function; 2. The protein should belong to C1orf127-like that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MWGSVAVVWAICLACIQPAVFPWILPVRSNKDRPRPAHGALTEKVECFSDYMTLQIPSSHVQGLKQWLVGVLRLPGSKRAPNHLDSLLTKCGYLLHPAHEGGFIFRALYSGCFVQKEKANYRLEIRMFQKGAKRLKQSDRYIMRCPMMVARLGEQSVRCHPSFIQVSRPWPPRTDAGQTPWLLSLRGELVASLEDASLMGLEVDIGATMVTIQSPRQELLQRQEVWNTSLELLPLWLVSGSYAYSFEAACPLVSSQPGSEISVHIPKQRLGLVKRGSLVEESLSPRFLQVQQTDTFTVAEDRDFVIVSIPSMRLLQDQPCQKARESPGTQAFYRVDLSLDFAEMDSPVHWTVENFFQCVGSREDSLFSTVTPRTTLPTQSPGWETTPAETPPAASPPLQTPQMAVLEEPPQHFVHQSAKESTKQELAAAFMQITRPARGSWVSMASPSSSAMQEHQGPQTPPEKADLSPHPQTPATLSSEHTEVSQAGPGPSHYVSLAPNSLSTHLSSEITSSLWPSWPSDGPPMLLSSEPSVKLTEVPRATRAGQDSIQPSRSPFPPGELSRETVNSTESTEPIPREPAYIREEFPPFTKSFMSSLAEEGLIFHPDPKRPQERPIVKAEKPLQNDHGPSGEETRHYLDLSTSEPSQEMKELGVDATFTTSRRRQPDARAYLGTSRPELTGRPRVGTAALQTTLHKGLLASTSERPAAPSEGALQLESAPSWPEGWHDLGAAHTASPLSSHTHSPLVPTQAMFPGSDEPGNSLPGSQGSVESRLLPTTDSHQSPEL" }, { "InterPro": [ { "InterPro-ID": "IPR027005", "InterPro-Name": "GlyclTrfase_39-like", "InterPro-Type": "FAMILY", "Beg": 319, "End": 515 }, { "InterPro-ID": "IPR032421", "InterPro-Name": "PMT_4TMC", "InterPro-Type": "DOMAIN", "Beg": 322, "End": 515 }, { "InterPro-ID": "IPR003342", "InterPro-Name": "Glyco_trans_39/83", "InterPro-Type": "DOMAIN", "Beg": 115, "End": 292 } ], "response#1": "MTALDTDTPTAGRSAPLISPGPVIPPPDFGPLDRAQGWAMTAIITALAAITRFLNLGSPTDAGTPIFDEKHYAPQAWQVLHNDGVEDNPGYGLVVHPPVGKQLIAIGEWLFGYNGLGWRFSGAVCGVIIVMLVTRIARRISRSTLVGAIAGLLIIADGVSFVSSRTALLDVFLVMFAVAAFACLMVDRDQVRERMYHAFLDGRIAETRWGTRLGVRWWRFGAGVLLGLACATKWSGLYFVLFFGVMTLVFDAIARKQYHVPHPWRGMLRRDLGPAAYVFGLIPFAVYLASYAPWFASETAVNRYEVGRSIGPDSILPIPDALRSLWHYTHAAYRFHSNLTNADGNHHPWESKPWTWPMSLRPVLYAIDNQDVPGCGAQSCVKAVMLVGTPAMWFIAVPVLGWALWRTVVRRDWRYGAVLVGYMAGFLPWFADIDRQMYFFYATVMAPFLVLAIALILGDILYKPNQNPERRTLGLLTVCFYVALVITNFAWMYPILTGLPISQTTWNLQIWLPSWR", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more PMT_4TMC, Glyco_trans_39/83 that are essential for its biological function; 2. The protein should belong to GlyclTrfase_39-like that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MTALDTDTPTAGRSAPLISPGPVIPPPDFGPLDRAQGWAMTAIITALAAITRFLNLGSPTDAGTPIFDEKHYAPQAWQVLHNDGVEDNPGYGLVVHPPVGKQLIAIGEWLFGYNGLGWRFSGAVCGVIIVMLVTRIARRISRSTLVGAIAGLLIIADGVSFVSSRTALLDVFLVMFAVAAFACLMVDRDQVRERMYHAFLDGRIAETRWGTRLGVRWWRFGAGVLLGLACATKWSGLYFVLFFGVMTLVFDAIARKQYHVPHPWRGMLRRDLGPAAYVFGLIPFAVYLASYAPWFASETAVNRYEVGRSIGPDSILPIPDALRSLWHYTHAAYRFHSNLTNADGNHHPWESKPWTWPMSLRPVLYAIDNQDVPGCGAQSCVKAVMLVGTPAMWFIAVPVLGWALWRTVVRRDWRYGAVLVGYMAGFLPWFADIDRQMYFFYATVMAPFLVLAIALILGDILYKPNQNPERRTLGLLTVCFYVALVITNFAWMYPILTGLPISQTTWNLQIWLPSWR" }, { "InterPro": [ { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 29, "End": 128 }, { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 29, "End": 131 } ], "response#1": "MFARLTSTLFALAAVSAVFAAPGATTEQCNGGEVQCCNSVQDANNLDSSVKKIITGLLHLDLKQITGQVGVTCTSVNVLGIGGGSSWYGFAFSYSYILASDWAIGVCSTQQKVCCTNNSFHGLIALGCTPINVSV", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Hydrophobin, Hydrophobin that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MFARLTSTLFALAAVSAVFAAPGATTEQCNGGEVQCCNSVQDANNLDSSVKKIITGLLHLDLKQITGQVGVTCTSVNVLGIGGGSSWYGFAFSYSYILASDWAIGVCSTQQKVCCTNNSFHGLIALGCTPINVSV" }, { "InterPro": [ { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 34, "End": 111 }, { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 34, "End": 114 } ], "response#1": "MFARLSTALLAFTLATAVVAAPGGRPSEVEYEQCNGGEIQCCNSYQKADSLDYNTSKLLGLLNIDVKQITAGVGLTCTGINAVGIGGGSSCTQQKVCCTNNKFNGVVALGCSPINVSL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Hydrophobin, Hydrophobin that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MFARLSTALLAFTLATAVVAAPGGRPSEVEYEQCNGGEIQCCNSYQKADSLDYNTSKLLGLLNIDVKQITAGVGLTCTGINAVGIGGGSSCTQQKVCCTNNKFNGVVALGCSPINVSL" }, { "InterPro": [ { "InterPro-ID": "IPR017795", "InterPro-Name": "Aro_prenylTrfase_DMATS", "InterPro-Type": "FAMILY", "Beg": 55, "End": 224 }, { "InterPro-ID": "IPR033964", "InterPro-Name": "Aro_prenylTrfase", "InterPro-Type": "FAMILY", "Beg": 70, "End": 330 } ], "response#1": "MTEELTTVRDACARTLENTARTLHLGASGTEFVAAFRAMTDHWGAARPHDLPLSDVSPDGSPVEYAVDLGGLAPALQFAMEPLTAGVPARDPLAARAIMPLLAGRYGADATRWSALADRLLPDDAHGPHVSMYGAEVRAGAPIRFKAWFYLNVTGPDGAFNLLYSALERMGTTHLWPVVQAHVHRAGEDVPFLLSLDLSDDPAARVKVYFRHFAADVEEVAAVLKAYPGFEPGEVRAFCKVMMGGRRRFSDQPAVTCVSLLDAQTFDRTAATLYVPLWTYAEHDGEVRQRVHRTLAAWPEALYRYDSVLAGIAHRGLDAGTGIHNYISWQPGRTRPRMKVYLSPEMHDVTPPPLGVSQQHHLSGQTTARGRTE", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Aro_prenylTrfase_DMATS, Aro_prenylTrfase that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MTEELTTVRDACARTLENTARTLHLGASGTEFVAAFRAMTDHWGAARPHDLPLSDVSPDGSPVEYAVDLGGLAPALQFAMEPLTAGVPARDPLAARAIMPLLAGRYGADATRWSALADRLLPDDAHGPHVSMYGAEVRAGAPIRFKAWFYLNVTGPDGAFNLLYSALERMGTTHLWPVVQAHVHRAGEDVPFLLSLDLSDDPAARVKVYFRHFAADVEEVAAVLKAYPGFEPGEVRAFCKVMMGGRRRFSDQPAVTCVSLLDAQTFDRTAATLYVPLWTYAEHDGEVRQRVHRTLAAWPEALYRYDSVLAGIAHRGLDAGTGIHNYISWQPGRTRPRMKVYLSPEMHDVTPPPLGVSQQHHLSGQTTARGRTE" }, { "InterPro": [ { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 268, "End": 279 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 233, "End": 250 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 343, "End": 354 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 334, "End": 343 }, { "InterPro-ID": "IPR036396", "InterPro-Name": "Cyt_P450_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 7, "End": 393 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 174, "End": 261 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 266, "End": 367 }, { "InterPro-ID": "IPR017972", "InterPro-Name": "Cyt_P450_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 336, "End": 345 }, { "InterPro-ID": "IPR002397", "InterPro-Name": "Cyt_P450_B", "InterPro-Type": "FAMILY", "Beg": 285, "End": 312 }, { "InterPro-ID": "IPR002397", "InterPro-Name": "Cyt_P450_B", "InterPro-Type": "FAMILY", "Beg": 143, "End": 158 }, { "InterPro-ID": "IPR002397", "InterPro-Name": "Cyt_P450_B", "InterPro-Type": "FAMILY", "Beg": 268, "End": 279 }, { "InterPro-ID": "IPR002397", "InterPro-Name": "Cyt_P450_B", "InterPro-Type": "FAMILY", "Beg": 80, "End": 91 }, { "InterPro-ID": "IPR002397", "InterPro-Name": "Cyt_P450_B", "InterPro-Type": "FAMILY", "Beg": 187, "End": 209 }, { "InterPro-ID": "IPR002397", "InterPro-Name": "Cyt_P450_B", "InterPro-Type": "FAMILY", "Beg": 313, "End": 328 }, { "InterPro-ID": "IPR002397", "InterPro-Name": "Cyt_P450_B", "InterPro-Type": "FAMILY", "Beg": 334, "End": 343 }, { "InterPro-ID": "IPR002397", "InterPro-Name": "Cyt_P450_B", "InterPro-Type": "FAMILY", "Beg": 343, "End": 354 }, { "InterPro-ID": "IPR002397", "InterPro-Name": "Cyt_P450_B", "InterPro-Type": "FAMILY", "Beg": 126, "End": 142 }, { "InterPro-ID": "IPR036396", "InterPro-Name": "Cyt_P450_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 8, "End": 394 } ], "response#1": "MGTAPAYSLDGGRSLHRWLRDMREHHPVHRELLTRVWTLYRYRDITQATADPAVFSSELWRYLPGDRGDDALTAGNLTAMDPPRHRLVRDLVSRSFTARAVGALRPRIAAIAAELIGAVADRGEMDVVADLSDPLPVLVIGELLGLPMADRELLSDWARRLLSFDKGDLTDEVVRKRVADTQQELLDYLRVHCRRRRTNPQDDLISRLIRAEVDGQRLTEDEVVNFANLLLLAGHVTTTLLLANIVLTLDEHPAVAAEARADRGLIPGLIEETLRYRPVIVSNMRVTTRAVTVGTEQLPAGQLVSLSFISGNRDEQYFTDPDRFDIHRDARKHLGFGHGIHYCLGAPLARLELGIALDAMFDRFSRIEVTGVPVDYYDTPGVAGPRSLRIAFRHH", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Cyt_P450, Cyt_P450, Cyt_P450, Cyt_P450, Cyt_P450, Cyt_P450, Cyt_P450_B, Cyt_P450_B, Cyt_P450_B, Cyt_P450_B, Cyt_P450_B, Cyt_P450_B, Cyt_P450_B, Cyt_P450_B, Cyt_P450_B that shares evolutionary origin and functional similarity; 2. The protein should be classified within Cyt_P450_sf, Cyt_P450_sf sharing conserved structural features; 3. The protein should contain Cyt_P450_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MGTAPAYSLDGGRSLHRWLRDMREHHPVHRELLTRVWTLYRYRDITQATADPAVFSSELWRYLPGDRGDDALTAGNLTAMDPPRHRLVRDLVSRSFTARAVGALRPRIAAIAAELIGAVADRGEMDVVADLSDPLPVLVIGELLGLPMADRELLSDWARRLLSFDKGDLTDEVVRKRVADTQQELLDYLRVHCRRRRTNPQDDLISRLIRAEVDGQRLTEDEVVNFANLLLLAGHVTTTLLLANIVLTLDEHPAVAAEARADRGLIPGLIEETLRYRPVIVSNMRVTTRAVTVGTEQLPAGQLVSLSFISGNRDEQYFTDPDRFDIHRDARKHLGFGHGIHYCLGAPLARLELGIALDAMFDRFSRIEVTGVPVDYYDTPGVAGPRSLRIAFRHH" }, { "InterPro": [ { "InterPro-ID": "IPR003750", "InterPro-Name": "Put_MeTrfase-C9orf114-like", "InterPro-Type": "FAMILY", "Beg": 73, "End": 361 }, { "InterPro-ID": "IPR003750", "InterPro-Name": "Put_MeTrfase-C9orf114-like", "InterPro-Type": "FAMILY", "Beg": 73, "End": 370 }, { "InterPro-ID": "IPR029026", "InterPro-Name": "tRNA_m1G_MTases_N", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 74, "End": 368 }, { "InterPro-ID": "IPR003750", "InterPro-Name": "Put_MeTrfase-C9orf114-like", "InterPro-Type": "FAMILY", "Beg": 21, "End": 375 }, { "InterPro-ID": "IPR012340", "InterPro-Name": "NA-bd_OB-fold", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 186, "End": 254 }, { "InterPro-ID": "IPR029028", "InterPro-Name": "Alpha/beta_knot_MTases", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 70, "End": 372 }, { "InterPro-ID": "IPR012340", "InterPro-Name": "NA-bd_OB-fold", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 184, "End": 265 } ], "response#1": "MKTMLAAPTASSNGRPIGPHKSWKKVNEERKALKRQRKQDKLLKELQQAKEAESQAGKAANEVQAKDKPNPSTLSIAVPGSILENAQSNELRAYVAGQIARAACIFRVNEVIVFDDVGIATARETKRSYEADGEGSSTGTVRSSSLQLARILQYLECPQYLRKYFFPLHKDLKYSGLLNPLDTPHHLRQQSKFRYREGVICDKKAKEGHSYANVGLLNDVLVDKAIEPGVRVTVKMEPQSESCRKQRGTLVSPDEPRRETGVYWGYQVRIAHSMSEIFTKSPYATGYDVTVGTSDRGTNVHEVPNRSYNFNHMLIVFGGLQGLESALANDEKLTVDDPELLFDHYVNVLPRQGSRTIRTEEALLIALAALQEKLQPQVADVEIDLTDLLPKSEDSGIAVRRDVLVSKKQKKRKQVEDTPDETVVDEPSFSKPLPKVARLTANPFADSSEELAKNTPAQDDFEVVSSTTVSGTSHSCADDDLSRFD", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Put_MeTrfase-C9orf114-like, Put_MeTrfase-C9orf114-like, Put_MeTrfase-C9orf114-like that shares evolutionary origin and functional similarity; 2. The protein should be classified within tRNA_m1G_MTases_N, NA-bd_OB-fold, Alpha/beta_knot_MTases, NA-bd_OB-fold sharing conserved structural features. The designed protein sequence is ", "reference": "MKTMLAAPTASSNGRPIGPHKSWKKVNEERKALKRQRKQDKLLKELQQAKEAESQAGKAANEVQAKDKPNPSTLSIAVPGSILENAQSNELRAYVAGQIARAACIFRVNEVIVFDDVGIATARETKRSYEADGEGSSTGTVRSSSLQLARILQYLECPQYLRKYFFPLHKDLKYSGLLNPLDTPHHLRQQSKFRYREGVICDKKAKEGHSYANVGLLNDVLVDKAIEPGVRVTVKMEPQSESCRKQRGTLVSPDEPRRETGVYWGYQVRIAHSMSEIFTKSPYATGYDVTVGTSDRGTNVHEVPNRSYNFNHMLIVFGGLQGLESALANDEKLTVDDPELLFDHYVNVLPRQGSRTIRTEEALLIALAALQEKLQPQVADVEIDLTDLLPKSEDSGIAVRRDVLVSKKQKKRKQVEDTPDETVVDEPSFSKPLPKVARLTANPFADSSEELAKNTPAQDDFEVVSSTTVSGTSHSCADDDLSRFD" }, { "InterPro": [ { "InterPro-ID": "IPR012340", "InterPro-Name": "NA-bd_OB-fold", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1, "End": 104 }, { "InterPro-ID": "IPR023646", "InterPro-Name": "Prisomal_replication_PriB", "InterPro-Type": "FAMILY", "Beg": 3, "End": 99 }, { "InterPro-ID": "IPR023646", "InterPro-Name": "Prisomal_replication_PriB", "InterPro-Type": "FAMILY", "Beg": 1, "End": 101 }, { "InterPro-ID": "IPR023646", "InterPro-Name": "Prisomal_replication_PriB", "InterPro-Type": "FAMILY", "Beg": 3, "End": 95 }, { "InterPro-ID": "IPR012340", "InterPro-Name": "NA-bd_OB-fold", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1, "End": 103 }, { "InterPro-ID": "IPR023646", "InterPro-Name": "Prisomal_replication_PriB", "InterPro-Type": "FAMILY", "Beg": 2, "End": 100 }, { "InterPro-ID": "IPR000424", "InterPro-Name": "Primosome_PriB/ssb", "InterPro-Type": "FAMILY", "Beg": 1, "End": 101 } ], "response#1": "MTNRLELSGIICRTPLRKVSPSGIPHCQFVLEHRSVQEEAGFHRQAWCQMPVIISGHENQAITHSITVGSAVTVRGFISCHKAKNGLSKMVLHAEQIELIDSGD", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Prisomal_replication_PriB, Prisomal_replication_PriB, Prisomal_replication_PriB, Prisomal_replication_PriB, Primosome_PriB/ssb that shares evolutionary origin and functional similarity; 2. The protein should be classified within NA-bd_OB-fold, NA-bd_OB-fold sharing conserved structural features. The designed protein sequence is ", "reference": "MTNRLELSGIICRTPLRKVSPSGIPHCQFVLEHRSVQEEAGFHRQAWCQMPVIISGHENQAITHSITVGSAVTVRGFISCHKAKNGLSKMVLHAEQIELIDSGD" }, { "InterPro": [ { "InterPro-ID": "IPR014038", "InterPro-Name": "EF1B_bsu/dsu_GNE", "InterPro-Type": "DOMAIN", "Beg": 139, "End": 225 }, { "InterPro-ID": "IPR018940", "InterPro-Name": "EF-1_beta_acid_region_euk", "InterPro-Type": "DOMAIN", "Beg": 103, "End": 130 }, { "InterPro-ID": "IPR001326", "InterPro-Name": "Transl_elong_EF1B_B/D_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 214, "End": 225 }, { "InterPro-ID": "IPR001326", "InterPro-Name": "Transl_elong_EF1B_B/D_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 97, "End": 105 }, { "InterPro-ID": "IPR014717", "InterPro-Name": "Transl_elong_EF1B/ribsomal_bS6", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 135, "End": 225 }, { "InterPro-ID": "IPR014038", "InterPro-Name": "EF1B_bsu/dsu_GNE", "InterPro-Type": "DOMAIN", "Beg": 137, "End": 225 }, { "InterPro-ID": "IPR049720", "InterPro-Name": "EF1B_bsu/dsu", "InterPro-Type": "FAMILY", "Beg": 8, "End": 225 }, { "InterPro-ID": "IPR036282", "InterPro-Name": "Glutathione-S-Trfase_C_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 7, "End": 63 }, { "InterPro-ID": "IPR014038", "InterPro-Name": "EF1B_bsu/dsu_GNE", "InterPro-Type": "DOMAIN", "Beg": 142, "End": 225 }, { "InterPro-ID": "IPR036219", "InterPro-Name": "eEF-1beta-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 137, "End": 225 } ], "response#1": "MGFGDLKTPAGLQVLNDYLADKSYIEGYVPSQADVAVFEAISGPPPADLCHALRWYNHIKSYEKEKASLPGVKKSLGKYGPVSVADTTGSGAADAKDDDDIDLFGSDDEEESEDAKRLREERLAQYESKKAKKPAVVAKSSILLDVKPWDDETDMTKLEECVRSIQADGLVWGSSKLVPVGYGIKKLQIQCVVEDDKVGTDMLEEQITAFEDYVQSMDVAAFNKI", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more EF1B_bsu/dsu_GNE, EF-1_beta_acid_region_euk, EF1B_bsu/dsu_GNE, EF1B_bsu/dsu_GNE that are essential for its biological function; 2. The protein should belong to EF1B_bsu/dsu that shares evolutionary origin and functional similarity; 3. The protein should be classified within Transl_elong_EF1B/ribsomal_bS6, Glutathione-S-Trfase_C_sf, eEF-1beta-like_sf sharing conserved structural features; 4. The protein should contain Transl_elong_EF1B_B/D_CS, Transl_elong_EF1B_B/D_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MGFGDLKTPAGLQVLNDYLADKSYIEGYVPSQADVAVFEAISGPPPADLCHALRWYNHIKSYEKEKASLPGVKKSLGKYGPVSVADTTGSGAADAKDDDDIDLFGSDDEEESEDAKRLREERLAQYESKKAKKPAVVAKSSILLDVKPWDDETDMTKLEECVRSIQADGLVWGSSKLVPVGYGIKKLQIQCVVEDDKVGTDMLEEQITAFEDYVQSMDVAAFNKI" }, { "InterPro": [ { "InterPro-ID": "IPR036259", "InterPro-Name": "MFS_trans_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 39, "End": 549 }, { "InterPro-ID": "IPR036259", "InterPro-Name": "MFS_trans_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 30, "End": 557 }, { "InterPro-ID": "IPR052599", "InterPro-Name": "SLC43A_AATransporter", "InterPro-Type": "FAMILY", "Beg": 39, "End": 559 } ], "response#1": "MKDSRGKRRCLAFLKGLRLKTDPNLPGAKQKTPFNISRFWLLVIIVIYTATSACIYFDWSAIRNLLLTVGKYKHLNVGDYPDITLSPQYKRINSLYPITLAIHFTMSVFCGFLYDHIGPKFTAIIGQMCNIMSWVFLSIDSTTVDTTFLSFVFLGLGADTAFIPILTISNLYPDASTFILTVVGAAASLSYAVPATLNFICRRYPSTPFPYICYGYIFLILVPCLLVATFLLPLMPFKGLDYYIERDQSRRSGAEGDAHRGRRGDPKMVTSQTNDEVDVEMQPFENAQSEASKGRSGNGSNTPSTRGNTPNGGKQTRGKTTSESNRSSKGEGSAIQGVEEEDQATNSSKGVNEEDSDFHRKSISLFFKVLLSYPSICIIVYFILFNISTVFYGMVTDTYFSYDRSIINIINILMPISCIPCIIFGRFINRYGSAIIIILMNAFSALMHLTALIKHRAAGLVSAFLYMCVTSIYTSQIYCFIQNSFPSVVFGKLLGFASLCGGLFSLLCEKLYDQIVSKDGASIDPTNVVLLLVIAFILMFLPLTVLYFRKYERSIEDLHQEVAMSQSSGRA", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to SLC43A_AATransporter that shares evolutionary origin and functional similarity; 2. The protein should be classified within MFS_trans_sf, MFS_trans_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MKDSRGKRRCLAFLKGLRLKTDPNLPGAKQKTPFNISRFWLLVIIVIYTATSACIYFDWSAIRNLLLTVGKYKHLNVGDYPDITLSPQYKRINSLYPITLAIHFTMSVFCGFLYDHIGPKFTAIIGQMCNIMSWVFLSIDSTTVDTTFLSFVFLGLGADTAFIPILTISNLYPDASTFILTVVGAAASLSYAVPATLNFICRRYPSTPFPYICYGYIFLILVPCLLVATFLLPLMPFKGLDYYIERDQSRRSGAEGDAHRGRRGDPKMVTSQTNDEVDVEMQPFENAQSEASKGRSGNGSNTPSTRGNTPNGGKQTRGKTTSESNRSSKGEGSAIQGVEEEDQATNSSKGVNEEDSDFHRKSISLFFKVLLSYPSICIIVYFILFNISTVFYGMVTDTYFSYDRSIINIINILMPISCIPCIIFGRFINRYGSAIIIILMNAFSALMHLTALIKHRAAGLVSAFLYMCVTSIYTSQIYCFIQNSFPSVVFGKLLGFASLCGGLFSLLCEKLYDQIVSKDGASIDPTNVVLLLVIAFILMFLPLTVLYFRKYERSIEDLHQEVAMSQSSGRA" }, { "InterPro": [ { "InterPro-ID": "IPR000453", "InterPro-Name": "Chorismate_synth", "InterPro-Type": "FAMILY", "Beg": 8, "End": 531 }, { "InterPro-ID": "IPR000453", "InterPro-Name": "Chorismate_synth", "InterPro-Type": "FAMILY", "Beg": 1, "End": 535 }, { "InterPro-ID": "IPR000453", "InterPro-Name": "Chorismate_synth", "InterPro-Type": "FAMILY", "Beg": 8, "End": 522 }, { "InterPro-ID": "IPR035904", "InterPro-Name": "Chorismate_synth_AroC_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 4, "End": 534 }, { "InterPro-ID": "IPR035904", "InterPro-Name": "Chorismate_synth_AroC_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 427, "End": 536 }, { "InterPro-ID": "IPR000453", "InterPro-Name": "Chorismate_synth", "InterPro-Type": "FAMILY", "Beg": 445, "End": 524 }, { "InterPro-ID": "IPR000453", "InterPro-Name": "Chorismate_synth", "InterPro-Type": "FAMILY", "Beg": 8, "End": 342 }, { "InterPro-ID": "IPR035904", "InterPro-Name": "Chorismate_synth_AroC_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1, "End": 375 } ], "response#1": "MSTYGTLLKVTSFGESHGKAIGCVIDGFLPNVEINFDLIQRQLNRRRPNQSKLTSNRNEPDKLIVLSGFDENKTLGTPITFLINNEDVIKKNYSSFIDIPRPGHGDYTYFKKYNVKNKSGSSRFSGRETATRVAAGACIEQWLHTFYNCTIVCYVHSVGNIKLPEQVSKDFERNPPSRDLVDAHGAVKYHQGRGTFTDFFGNVYNANGEFLRGGEAAPEGATPADGTPTDGNPTDDPLANARERLSDPGECTLLQTRCPHPLTAVKICSYILKLKKAGDSIGGVATCIAHNVPVGIGEPIFEKMEAELGKIILSIPAVKGIEFGSGFDGTYMLGSDHNDLFGTLDVPEEGPCQRGWTLTDALDSKRGEVTPGGSRAQEGTSFEKDACHRSGHLSNLSGYPSNGSGNPPNGSDHPSNRSGNPPNRSDPRVDESTRETSPPSGEKLLVTTSNNCGGILAGITTGNNIVFRSAIKPVSSIQIEKETCNFFGEKCKLKVTGMHDCCILPRLPPIIEASTSIVIGDMILRQVAKYGHSKLPSVGSLSRSTRE", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Chorismate_synth, Chorismate_synth, Chorismate_synth, Chorismate_synth, Chorismate_synth that shares evolutionary origin and functional similarity; 2. The protein should be classified within Chorismate_synth_AroC_sf, Chorismate_synth_AroC_sf, Chorismate_synth_AroC_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MSTYGTLLKVTSFGESHGKAIGCVIDGFLPNVEINFDLIQRQLNRRRPNQSKLTSNRNEPDKLIVLSGFDENKTLGTPITFLINNEDVIKKNYSSFIDIPRPGHGDYTYFKKYNVKNKSGSSRFSGRETATRVAAGACIEQWLHTFYNCTIVCYVHSVGNIKLPEQVSKDFERNPPSRDLVDAHGAVKYHQGRGTFTDFFGNVYNANGEFLRGGEAAPEGATPADGTPTDGNPTDDPLANARERLSDPGECTLLQTRCPHPLTAVKICSYILKLKKAGDSIGGVATCIAHNVPVGIGEPIFEKMEAELGKIILSIPAVKGIEFGSGFDGTYMLGSDHNDLFGTLDVPEEGPCQRGWTLTDALDSKRGEVTPGGSRAQEGTSFEKDACHRSGHLSNLSGYPSNGSGNPPNGSDHPSNRSGNPPNRSDPRVDESTRETSPPSGEKLLVTTSNNCGGILAGITTGNNIVFRSAIKPVSSIQIEKETCNFFGEKCKLKVTGMHDCCILPRLPPIIEASTSIVIGDMILRQVAKYGHSKLPSVGSLSRSTRE" }, { "InterPro": [ { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 27, "End": 102 }, { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 27, "End": 105 }, { "InterPro-ID": "IPR019778", "InterPro-Name": "Hydrophobin_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 79, "End": 90 } ], "response#1": "MFSKLAIFATAAFAVLAAATPVRRQQCTTGQLQCCESTSTANDPATSELLGLIGVVISDVDALVGLTCSPISVIGVGSGSACTANPVCCDSSPIGGLVSIGCVPVNV", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Hydrophobin, Hydrophobin that shares evolutionary origin and functional similarity; 2. The protein should contain Hydrophobin_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MFSKLAIFATAAFAVLAAATPVRRQQCTTGQLQCCESTSTANDPATSELLGLIGVVISDVDALVGLTCSPISVIGVGSGSACTANPVCCDSSPIGGLVSIGCVPVNV" }, { "InterPro": [ { "InterPro-ID": "IPR010636", "InterPro-Name": "Cerato-ulmin_hydrophobin", "InterPro-Type": "FAMILY", "Beg": 27, "End": 91 }, { "InterPro-ID": "IPR036686", "InterPro-Name": "Hydrophobin_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 27, "End": 94 }, { "InterPro-ID": "IPR036686", "InterPro-Name": "Hydrophobin_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 21, "End": 95 }, { "InterPro-ID": "IPR010636", "InterPro-Name": "Cerato-ulmin_hydrophobin", "InterPro-Type": "FAMILY", "Beg": 28, "End": 91 }, { "InterPro-ID": "IPR010636", "InterPro-Name": "Cerato-ulmin_hydrophobin", "InterPro-Type": "FAMILY", "Beg": 7, "End": 92 } ], "response#1": "MKLLAVAALLAGAAIAAPTSNTGGGSVCPSGLYSNPQCCSTVIIGVIALDCKSPSEVPRDGTDLRNICAKTGQKAACCVIPVAGQALLCETAPGA", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Cerato-ulmin_hydrophobin, Cerato-ulmin_hydrophobin, Cerato-ulmin_hydrophobin that shares evolutionary origin and functional similarity; 2. The protein should be classified within Hydrophobin_sf, Hydrophobin_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MKLLAVAALLAGAAIAAPTSNTGGGSVCPSGLYSNPQCCSTVIIGVIALDCKSPSEVPRDGTDLRNICAKTGQKAACCVIPVAGQALLCETAPGA" }, { "InterPro": [ { "InterPro-ID": "IPR013087", "InterPro-Name": "Znf_C2H2_type", "InterPro-Type": "DOMAIN", "Beg": 438, "End": 465 }, { "InterPro-ID": "IPR013087", "InterPro-Name": "Znf_C2H2_type", "InterPro-Type": "DOMAIN", "Beg": 411, "End": 432 }, { "InterPro-ID": "IPR013087", "InterPro-Name": "Znf_C2H2_type", "InterPro-Type": "DOMAIN", "Beg": 409, "End": 432 }, { "InterPro-ID": "IPR013087", "InterPro-Name": "Znf_C2H2_type", "InterPro-Type": "DOMAIN", "Beg": 438, "End": 460 }, { "InterPro-ID": "IPR013087", "InterPro-Name": "Znf_C2H2_type", "InterPro-Type": "DOMAIN", "Beg": 440, "End": 460 }, { "InterPro-ID": "IPR051059", "InterPro-Name": "VerF-like", "InterPro-Type": "FAMILY", "Beg": 382, "End": 473 }, { "InterPro-ID": "IPR036236", "InterPro-Name": "Znf_C2H2_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 407, "End": 460 }, { "InterPro-ID": "IPR013087", "InterPro-Name": "Znf_C2H2_type", "InterPro-Type": "DOMAIN", "Beg": 409, "End": 437 } ], "response#1": "MDSNMMPQTAQQNAVFSKTNFAQQKLGQYQVVAPASPVCSRPGSSCSQPPTLFSNGPAVLTPTGSPPPIGFRPAVMLESEFGDSSYFPSTPPLSTSGSAVGSPKNYEVLQTPLNPMFSGLDGFVGVKSGYESTESSVLDWASCDSPPMTPVFIHSQPSRVPSLSSTTSDLSNISCPSLSPSPAPYARSVSSENDVDFCDPRNLTVPNTSNSSLAPEFTLDCLGEEEGSPSEQSALDTVLSQTAFDFSPAIASGLPAFEELSDFESEDDLSNLVKPGEGSRPRACTGSSIVSLGHGSFIADEDFSFDENDTFQFPSPSPPSSVEAVDDGHKDKRQKKTGTKDSQSAEPVMDTAAADNQTAEVEEQSEQASPVPSESHSSAEADTPSAPLPAPTNRRGRKQSLTEDPSKTFVCDLCNRRFRRQEHLKRHYRSLHTQEKPFECNECGKKFSRSDNLAQHARTHASGGAIVMNIIDNADPSAYEAGMVAPPPVDDYANYGKVLFQIAADVPGSASELSSEEASDNGKKKRKRSE", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Znf_C2H2_type, Znf_C2H2_type, Znf_C2H2_type, Znf_C2H2_type, Znf_C2H2_type, Znf_C2H2_type that are essential for its biological function; 2. The protein should belong to VerF-like that shares evolutionary origin and functional similarity; 3. The protein should be classified within Znf_C2H2_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MDSNMMPQTAQQNAVFSKTNFAQQKLGQYQVVAPASPVCSRPGSSCSQPPTLFSNGPAVLTPTGSPPPIGFRPAVMLESEFGDSSYFPSTPPLSTSGSAVGSPKNYEVLQTPLNPMFSGLDGFVGVKSGYESTESSVLDWASCDSPPMTPVFIHSQPSRVPSLSSTTSDLSNISCPSLSPSPAPYARSVSSENDVDFCDPRNLTVPNTSNSSLAPEFTLDCLGEEEGSPSEQSALDTVLSQTAFDFSPAIASGLPAFEELSDFESEDDLSNLVKPGEGSRPRACTGSSIVSLGHGSFIADEDFSFDENDTFQFPSPSPPSSVEAVDDGHKDKRQKKTGTKDSQSAEPVMDTAAADNQTAEVEEQSEQASPVPSESHSSAEADTPSAPLPAPTNRRGRKQSLTEDPSKTFVCDLCNRRFRRQEHLKRHYRSLHTQEKPFECNECGKKFSRSDNLAQHARTHASGGAIVMNIIDNADPSAYEAGMVAPPPVDDYANYGKVLFQIAADVPGSASELSSEEASDNGKKKRKRSE" }, { "InterPro": [ { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 29, "End": 94 }, { "InterPro-ID": "IPR019778", "InterPro-Name": "Hydrophobin_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 68, "End": 79 }, { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 28, "End": 91 } ], "response#1": "MFKALIVALAAVAAAIPTQQPSSNEMNCDSGVYCCNKVAQNTGIVVPIDALSSTCGDTLKLVTVDALNDKCTSQTVCCNNVQQNGLVNVACTPIDV", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Hydrophobin, Hydrophobin that shares evolutionary origin and functional similarity; 2. The protein should contain Hydrophobin_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MFKALIVALAAVAAAIPTQQPSSNEMNCDSGVYCCNKVAQNTGIVVPIDALSSTCGDTLKLVTVDALNDKCTSQTVCCNNVQQNGLVNVACTPIDV" }, { "InterPro": [ { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 37, "End": 100 }, { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 37, "End": 97 } ], "response#1": "MSLFKILVAAATVATALAAPHEHKKPHPSYGDANAQCGNHQKLSCCNRGDSGGVLDGLLGGNCQPINILALLPIQNQCTNQVACCTGNSNGLINIPCTNVNL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Hydrophobin, Hydrophobin that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MSLFKILVAAATVATALAAPHEHKKPHPSYGDANAQCGNHQKLSCCNRGDSGGVLDGLLGGNCQPINILALLPIQNQCTNQVACCTGNSNGLINIPCTNVNL" }, { "InterPro": [ { "InterPro-ID": "IPR000679", "InterPro-Name": "Znf_GATA", "InterPro-Type": "DOMAIN", "Beg": 463, "End": 489 }, { "InterPro-ID": "IPR000679", "InterPro-Name": "Znf_GATA", "InterPro-Type": "DOMAIN", "Beg": 457, "End": 489 }, { "InterPro-ID": "IPR013655", "InterPro-Name": "PAS_fold_3", "InterPro-Type": "DOMAIN", "Beg": 188, "End": 249 }, { "InterPro-ID": "IPR000014", "InterPro-Name": "PAS", "InterPro-Type": "DOMAIN", "Beg": 175, "End": 249 }, { "InterPro-ID": "IPR000014", "InterPro-Name": "PAS", "InterPro-Type": "DOMAIN", "Beg": 166, "End": 232 }, { "InterPro-ID": "IPR000679", "InterPro-Name": "Znf_GATA", "InterPro-Type": "DOMAIN", "Beg": 463, "End": 488 }, { "InterPro-ID": "IPR000014", "InterPro-Name": "PAS", "InterPro-Type": "DOMAIN", "Beg": 171, "End": 247 }, { "InterPro-ID": "IPR035965", "InterPro-Name": "PAS-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 169, "End": 249 }, { "InterPro-ID": "IPR013088", "InterPro-Name": "Znf_NHR/GATA", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 452, "End": 498 }, { "InterPro-ID": "IPR000679", "InterPro-Name": "Znf_GATA", "InterPro-Type": "DOMAIN", "Beg": 457, "End": 507 }, { "InterPro-ID": "IPR000679", "InterPro-Name": "Znf_GATA", "InterPro-Type": "DOMAIN", "Beg": 463, "End": 490 }, { "InterPro-ID": "IPR000014", "InterPro-Name": "PAS", "InterPro-Type": "DOMAIN", "Beg": 170, "End": 234 } ], "response#1": "MIAARHYRKWWLSHIWPKDFSWLVPIESSSVPGPPECPALDEKFQSCQTVDNISLARRVGPPALLYSTGIDSSIAALVARVSCIPTGGHSSCPREYFLSAKTSLVSLVPTMDWTAAEHESGVTQNHQHRMQTEDHDSFAGEIQKLPSPPAGNTGGQNPSDPADEQGWPQRVLNEMKDMLLLLSSDGKILYASPSCKSITGYDANQLQQNALERFIHNDDKTTFAEEMNECITTTRPVHCHFRFRKKDNSSNTSCLLEAHGHPHMKTSEPNDSPENHNEDCIGVFLLCRPYPTRGSQLLDSFLEHKIENVRLNQRIAQLREEEEEDLASGQQLYAGDSTGDSGFRHNSHSGRSNSNQSSFRDTTGSGEENESSDTLTNDDPDSRSYLENAADELGQTEDMSHIEGIEMLTGLHYGDGERSQGLSTGVRQGRLIRYDMESAKLDQQARVIQDSDRKKRQKGEYMCTDCGTSDSPEWRKGPEGPKTLCNACGCKSAVQYTLFSYSSEMSS", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Znf_GATA, Znf_GATA, PAS_fold_3, PAS, PAS, Znf_GATA, PAS, Znf_GATA, Znf_GATA, PAS that are essential for its biological function; 2. The protein should be classified within PAS-like_dom_sf, Znf_NHR/GATA sharing conserved structural features. The designed protein sequence is ", "reference": "MIAARHYRKWWLSHIWPKDFSWLVPIESSSVPGPPECPALDEKFQSCQTVDNISLARRVGPPALLYSTGIDSSIAALVARVSCIPTGGHSSCPREYFLSAKTSLVSLVPTMDWTAAEHESGVTQNHQHRMQTEDHDSFAGEIQKLPSPPAGNTGGQNPSDPADEQGWPQRVLNEMKDMLLLLSSDGKILYASPSCKSITGYDANQLQQNALERFIHNDDKTTFAEEMNECITTTRPVHCHFRFRKKDNSSNTSCLLEAHGHPHMKTSEPNDSPENHNEDCIGVFLLCRPYPTRGSQLLDSFLEHKIENVRLNQRIAQLREEEEEDLASGQQLYAGDSTGDSGFRHNSHSGRSNSNQSSFRDTTGSGEENESSDTLTNDDPDSRSYLENAADELGQTEDMSHIEGIEMLTGLHYGDGERSQGLSTGVRQGRLIRYDMESAKLDQQARVIQDSDRKKRQKGEYMCTDCGTSDSPEWRKGPEGPKTLCNACGCKSAVQYTLFSYSSEMSS" }, { "InterPro": [ { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 45, "End": 131 }, { "InterPro-ID": "IPR019778", "InterPro-Name": "Hydrophobin_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 104, "End": 115 }, { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 45, "End": 134 } ], "response#1": "MRFSAATVSALAMALTVAAAPGNTAKEALAKRTDDLTVADAQNICGKDLSVNCCNQVDASTNNNDNSGSGILSGILGGVLGNGGLKLTDGCSSIGVGIANDLLNSQCKQSVACCKTDGNTASGLVAVQLPCIPISGLL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Hydrophobin, Hydrophobin that shares evolutionary origin and functional similarity; 2. The protein should contain Hydrophobin_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MRFSAATVSALAMALTVAAAPGNTAKEALAKRTDDLTVADAQNICGKDLSVNCCNQVDASTNNNDNSGSGILSGILGGVLGNGGLKLTDGCSSIGVGIANDLLNSQCKQSVACCKTDGNTASGLVAVQLPCIPISGLL" }, { "InterPro": [ { "InterPro-ID": "IPR000033", "InterPro-Name": "LDLR_classB_rpt", "InterPro-Type": "REPEAT", "Beg": 87, "End": 132 }, { "InterPro-ID": "IPR000033", "InterPro-Name": "LDLR_classB_rpt", "InterPro-Type": "REPEAT", "Beg": 38, "End": 86 }, { "InterPro-ID": "IPR000033", "InterPro-Name": "LDLR_classB_rpt", "InterPro-Type": "REPEAT", "Beg": 196, "End": 245 }, { "InterPro-ID": "IPR011042", "InterPro-Name": "6-blade_b-propeller_TolB-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 143, "End": 309 }, { "InterPro-ID": "IPR011042", "InterPro-Name": "6-blade_b-propeller_TolB-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 5, "End": 142 }, { "InterPro-ID": "IPR050778", "InterPro-Name": "Cueball_EGF_LRP_Nidogen", "InterPro-Type": "FAMILY", "Beg": 9, "End": 136 } ], "response#1": "MSTQPSHRLYILDTDLSTNVSTRHGRIISCRPDGSDLRTVVDGIKNLPDGIVVDHDRGLMYWTSMGTSLSAEGGSIERAKLDGSDHKTIIASGTVGVFTPKQITLARRSGKLYWCDREGMKVMRANTDGSGVEVLWSTGNAAEEDDRRDQMRWCVGVGVDEERGFVYWTQKGPSKGGKGRVFRGPLSQSPFSPDDVEVLIDGLPEPIDLEVDEQSGTLYWTDRGDPPTGNSLNCVSIADVEGVMNGTARGQVRTLARRLHETIGLALDKSGGVCYVTDLAGGVYAVDIKSGQKTVIFSELGDTTGIALV", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Cueball_EGF_LRP_Nidogen that shares evolutionary origin and functional similarity; 2. The protein should be classified within 6-blade_b-propeller_TolB-like, 6-blade_b-propeller_TolB-like sharing conserved structural features; 3. The protein should include one or more LDLR_classB_rpt, LDLR_classB_rpt, LDLR_classB_rpt that provide structural or functional support. The designed protein sequence is ", "reference": "MSTQPSHRLYILDTDLSTNVSTRHGRIISCRPDGSDLRTVVDGIKNLPDGIVVDHDRGLMYWTSMGTSLSAEGGSIERAKLDGSDHKTIIASGTVGVFTPKQITLARRSGKLYWCDREGMKVMRANTDGSGVEVLWSTGNAAEEDDRRDQMRWCVGVGVDEERGFVYWTQKGPSKGGKGRVFRGPLSQSPFSPDDVEVLIDGLPEPIDLEVDEQSGTLYWTDRGDPPTGNSLNCVSIADVEGVMNGTARGQVRTLARRLHETIGLALDKSGGVCYVTDLAGGVYAVDIKSGQKTVIFSELGDTTGIALV" }, { "InterPro": [ { "InterPro-ID": "IPR013087", "InterPro-Name": "Znf_C2H2_type", "InterPro-Type": "DOMAIN", "Beg": 451, "End": 471 }, { "InterPro-ID": "IPR036236", "InterPro-Name": "Znf_C2H2_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 418, "End": 471 }, { "InterPro-ID": "IPR013087", "InterPro-Name": "Znf_C2H2_type", "InterPro-Type": "DOMAIN", "Beg": 449, "End": 471 }, { "InterPro-ID": "IPR013087", "InterPro-Name": "Znf_C2H2_type", "InterPro-Type": "DOMAIN", "Beg": 420, "End": 443 }, { "InterPro-ID": "IPR013087", "InterPro-Name": "Znf_C2H2_type", "InterPro-Type": "DOMAIN", "Beg": 422, "End": 443 }, { "InterPro-ID": "IPR050589", "InterPro-Name": "Ikaros_C2H2-ZF", "InterPro-Type": "FAMILY", "Beg": 311, "End": 472 }, { "InterPro-ID": "IPR013087", "InterPro-Name": "Znf_C2H2_type", "InterPro-Type": "DOMAIN", "Beg": 420, "End": 448 } ], "response#1": "MESMMAAHPMYMMQYQYDNRQHAHYAHLPSQQPMAFYPAVPMVPSTPTYSRPASACSQPAMQSMKQMPMTSYPSAMTPMASPQPMARRSNIVLETEACDWEGKRHQAHGIYYPSTPPLSSSGSAISSPESCDMLSTPMNPMFSGLDSIESIKPEVNSPESFPVLEWTSCASPPMTPVYLNNVNNNLHSKQNLRPAPTSSCSPELAPAVSACPSLSPSPVPQTRSFTSETSFCDPRNLTVGNVTLGLEPASLSTETLVAQADNSFVFVAPQAAPTWDAISELESEEDFVKGLVNLDDSKSDAQGTRTRASSDAVSLNFDEVEAFPLLPTAHTHSDDDCHKSKRQRTCGGPKMDSATNESASSAAAPSSEQQQQPKSSDVPSNEETKSNSGASTNSDGTGLPAPTSRRGRKQSLTEDPSKAFKCELCDRRFRRQEHLKRHYRSLHTQDKPFECNECGKKFSRSDNLTQHARTHGSGAIPLNIMGEEDLAAAAANGYMHPPQHMYSMVPNVPTLPDYNSYGKVLFQIAAEVPGSASDYSDDGSERKRKRTD", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Znf_C2H2_type, Znf_C2H2_type, Znf_C2H2_type, Znf_C2H2_type, Znf_C2H2_type that are essential for its biological function; 2. The protein should belong to Ikaros_C2H2-ZF that shares evolutionary origin and functional similarity; 3. The protein should be classified within Znf_C2H2_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MESMMAAHPMYMMQYQYDNRQHAHYAHLPSQQPMAFYPAVPMVPSTPTYSRPASACSQPAMQSMKQMPMTSYPSAMTPMASPQPMARRSNIVLETEACDWEGKRHQAHGIYYPSTPPLSSSGSAISSPESCDMLSTPMNPMFSGLDSIESIKPEVNSPESFPVLEWTSCASPPMTPVYLNNVNNNLHSKQNLRPAPTSSCSPELAPAVSACPSLSPSPVPQTRSFTSETSFCDPRNLTVGNVTLGLEPASLSTETLVAQADNSFVFVAPQAAPTWDAISELESEEDFVKGLVNLDDSKSDAQGTRTRASSDAVSLNFDEVEAFPLLPTAHTHSDDDCHKSKRQRTCGGPKMDSATNESASSAAAPSSEQQQQPKSSDVPSNEETKSNSGASTNSDGTGLPAPTSRRGRKQSLTEDPSKAFKCELCDRRFRRQEHLKRHYRSLHTQDKPFECNECGKKFSRSDNLTQHARTHGSGAIPLNIMGEEDLAAAAANGYMHPPQHMYSMVPNVPTLPDYNSYGKVLFQIAAEVPGSASDYSDDGSERKRKRTD" }, { "InterPro": [ { "InterPro-ID": "IPR014748", "InterPro-Name": "Enoyl-CoA_hydra_C", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 292, "End": 349 }, { "InterPro-ID": "IPR001753", "InterPro-Name": "Enoyl-CoA_hydra/iso", "InterPro-Type": "FAMILY", "Beg": 122, "End": 348 }, { "InterPro-ID": "IPR029045", "InterPro-Name": "ClpP/crotonase-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 57, "End": 349 } ], "response#1": "MPPVSRILSYAPRVAIRPSSQLARPARAFAVGTVRYYSAEQPEEPLIRVTDLPAPNSGHIRVLELNRPKARNAISRALLASLREEVHSIARQYDAQTGEEIPTPSWNKRFGGIAGDSEKGPTRALVLASAVESSFCAGADLKERRGFTQEETNEFLANLRSTFAALDALPIPTISAISSRALGGGLELALCTHFRVLTSNAIVSLPETRLGIIPGAGGTHRLPRLIGLGRARDMIVTGRAVSGAEAYFLGLADRLVEVLPPDEQEAADTTDKDAALLSAAREAALTEAVRLASQICEGGPIGIRAALQAVQAPSQETENKMYERVIGTEDRNEALKAFAEKRKPVFKGR", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Enoyl-CoA_hydra/iso that shares evolutionary origin and functional similarity; 2. The protein should be classified within Enoyl-CoA_hydra_C, ClpP/crotonase-like_dom_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MPPVSRILSYAPRVAIRPSSQLARPARAFAVGTVRYYSAEQPEEPLIRVTDLPAPNSGHIRVLELNRPKARNAISRALLASLREEVHSIARQYDAQTGEEIPTPSWNKRFGGIAGDSEKGPTRALVLASAVESSFCAGADLKERRGFTQEETNEFLANLRSTFAALDALPIPTISAISSRALGGGLELALCTHFRVLTSNAIVSLPETRLGIIPGAGGTHRLPRLIGLGRARDMIVTGRAVSGAEAYFLGLADRLVEVLPPDEQEAADTTDKDAALLSAAREAALTEAVRLASQICEGGPIGIRAALQAVQAPSQETENKMYERVIGTEDRNEALKAFAEKRKPVFKGR" }, { "InterPro": [ { "InterPro-ID": "IPR036396", "InterPro-Name": "Cyt_P450_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 26, "End": 492 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 53, "End": 469 }, { "InterPro-ID": "IPR036396", "InterPro-Name": "Cyt_P450_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 34, "End": 488 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 286, "End": 303 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 349, "End": 367 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 306, "End": 332 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 437, "End": 460 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 391, "End": 415 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 427, "End": 437 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 350, "End": 361 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 428, "End": 437 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 437, "End": 448 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 297, "End": 314 }, { "InterPro-ID": "IPR050121", "InterPro-Name": "Cytochrome_P450_monoxygenase", "InterPro-Type": "FAMILY", "Beg": 10, "End": 461 } ], "response#1": "MDLLQRAGLVVGLWVTYHILLGTYNVFFHPLRRFPGPRLAAATQLVNVYYIIRGINCKYLYELHEKYGDVVRTGPNELSFRTASAIRTIYGGNPGPDDTFHKNMIANIQETGDSDNLFFATGQQHNRYRRLIMPVFAERTIQGQGPMMQEYCSQLIQGLRNRCGRGYFPTQDGVVDIVPWTHFIISDILSHMLFGSGMNCLLNGDYHPWVMAGYKALIESTYIEAAHRLRPYHRILEYLLIPTRLRDGFRVHSAVSREKLQARSKEAEPYQFSLPSFTSESLSEQELFDNINVIATAAGETTSSALSAIMYYLTANPAAYDKAVTEVRQAFSNEAEITAASSASLPYLKAVIREAFRIRPTIPVGLHRLTPKGGREIDGKWVPAGTWISVANLAACRTSSHWKEAGRFIPERWLGDPEFASDNRDTSVPYSIGVRNCIGMSHANTQLRLILSRLLWNFDFEACPGNADPYDYLEYGTWQVEPLKLRVVDIRGQPK", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Cyt_P450, Cyt_P450_E_grp-I, Cyt_P450_E_grp-I, Cyt_P450_E_grp-I, Cyt_P450_E_grp-I, Cyt_P450_E_grp-I, Cyt_P450_E_grp-I, Cyt_P450, Cyt_P450, Cyt_P450, Cyt_P450, Cytochrome_P450_monoxygenase that shares evolutionary origin and functional similarity; 2. The protein should be classified within Cyt_P450_sf, Cyt_P450_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MDLLQRAGLVVGLWVTYHILLGTYNVFFHPLRRFPGPRLAAATQLVNVYYIIRGINCKYLYELHEKYGDVVRTGPNELSFRTASAIRTIYGGNPGPDDTFHKNMIANIQETGDSDNLFFATGQQHNRYRRLIMPVFAERTIQGQGPMMQEYCSQLIQGLRNRCGRGYFPTQDGVVDIVPWTHFIISDILSHMLFGSGMNCLLNGDYHPWVMAGYKALIESTYIEAAHRLRPYHRILEYLLIPTRLRDGFRVHSAVSREKLQARSKEAEPYQFSLPSFTSESLSEQELFDNINVIATAAGETTSSALSAIMYYLTANPAAYDKAVTEVRQAFSNEAEITAASSASLPYLKAVIREAFRIRPTIPVGLHRLTPKGGREIDGKWVPAGTWISVANLAACRTSSHWKEAGRFIPERWLGDPEFASDNRDTSVPYSIGVRNCIGMSHANTQLRLILSRLLWNFDFEACPGNADPYDYLEYGTWQVEPLKLRVVDIRGQPK" }, { "InterPro": [ { "InterPro-ID": "IPR011009", "InterPro-Name": "Kinase-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 10, "End": 330 } ], "response#1": "MGTTERESDPIAALILDRLSCTEYACSSLSRVNGGLMNFIYRGTLSRPLPDGATTVIVKHAEEYLSGIEGLSLSTYRSVIAAITLSFGYCVMDVESVQTNRYCVALDEVEVAVPRVYKFDAESNTQILEDITGYITVCEFLTSRCTQSTSPAFTTRLGFRLGSWLGGLHAWGEGRSPAEIIGGVEENQEAQDGSFDFFYGNPVRRVEQFPHLLGDCKEVLEQIRDRAAREQKSRTGEKFGFVHGDILSRKSVLIPGDSVTRDQHLRFVIIDWELSQYECHFRECGEVLGDLYLLKRFQDIDGAMSIIQGFLEGYPPLNEDAIFRTAIYLGLFLLANEVTLSTDYPKQQIEDFVILARDLVLAGWHKDRETLAKTVFGPVFFRAMN", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should be classified within Kinase-like_dom_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MGTTERESDPIAALILDRLSCTEYACSSLSRVNGGLMNFIYRGTLSRPLPDGATTVIVKHAEEYLSGIEGLSLSTYRSVIAAITLSFGYCVMDVESVQTNRYCVALDEVEVAVPRVYKFDAESNTQILEDITGYITVCEFLTSRCTQSTSPAFTTRLGFRLGSWLGGLHAWGEGRSPAEIIGGVEENQEAQDGSFDFFYGNPVRRVEQFPHLLGDCKEVLEQIRDRAAREQKSRTGEKFGFVHGDILSRKSVLIPGDSVTRDQHLRFVIIDWELSQYECHFRECGEVLGDLYLLKRFQDIDGAMSIIQGFLEGYPPLNEDAIFRTAIYLGLFLLANEVTLSTDYPKQQIEDFVILARDLVLAGWHKDRETLAKTVFGPVFFRAMN" }, { "InterPro": [ { "InterPro-ID": "IPR035971", "InterPro-Name": "CBD_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 262, "End": 294 }, { "InterPro-ID": "IPR013320", "InterPro-Name": "ConA-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 30, "End": 226 }, { "InterPro-ID": "IPR033123", "InterPro-Name": "GH11_dom", "InterPro-Type": "DOMAIN", "Beg": 31, "End": 226 }, { "InterPro-ID": "IPR000254", "InterPro-Name": "Cellulose-bd_dom_fun", "InterPro-Type": "DOMAIN", "Beg": 267, "End": 293 }, { "InterPro-ID": "IPR001137", "InterPro-Name": "Glyco_hydro_11", "InterPro-Type": "FAMILY", "Beg": 1, "End": 226 }, { "InterPro-ID": "IPR000254", "InterPro-Name": "Cellulose-bd_dom_fun", "InterPro-Type": "DOMAIN", "Beg": 263, "End": 290 }, { "InterPro-ID": "IPR033119", "InterPro-Name": "GH11_AS_2", "InterPro-Type": "ACTIVE_SITE", "Beg": 210, "End": 221 }, { "InterPro-ID": "IPR013319", "InterPro-Name": "GH11/12", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 31, "End": 228 }, { "InterPro-ID": "IPR033123", "InterPro-Name": "GH11_dom", "InterPro-Type": "DOMAIN", "Beg": 40, "End": 223 }, { "InterPro-ID": "IPR001137", "InterPro-Name": "Glyco_hydro_11", "InterPro-Type": "FAMILY", "Beg": 172, "End": 181 }, { "InterPro-ID": "IPR001137", "InterPro-Name": "Glyco_hydro_11", "InterPro-Type": "FAMILY", "Beg": 195, "End": 203 }, { "InterPro-ID": "IPR001137", "InterPro-Name": "Glyco_hydro_11", "InterPro-Type": "FAMILY", "Beg": 167, "End": 172 }, { "InterPro-ID": "IPR001137", "InterPro-Name": "Glyco_hydro_11", "InterPro-Type": "FAMILY", "Beg": 147, "End": 153 }, { "InterPro-ID": "IPR001137", "InterPro-Name": "Glyco_hydro_11", "InterPro-Type": "FAMILY", "Beg": 102, "End": 111 }, { "InterPro-ID": "IPR000254", "InterPro-Name": "Cellulose-bd_dom_fun", "InterPro-Type": "DOMAIN", "Beg": 259, "End": 294 }, { "InterPro-ID": "IPR000254", "InterPro-Name": "Cellulose-bd_dom_fun", "InterPro-Type": "DOMAIN", "Beg": 262, "End": 294 } ], "response#1": "MVCFSSLFVAASAIAGVFASPVDHEQLAKRQSTPSSQGTHDGYFYSWWTDGGAAATYTNLAGGEYSVSWSNGGNLVGGKGWNPGSARTITYSGTYNPNGNSYLAVYGWTRNPQPWLTPLVVEYYVVENFGTYNPSSGATARGQVTHDGALYRLFESTRTNQPSIDGTATFQQYWAVRDVKRTGGTVNMATFFNAWTAAGMRLGTHNYQVVATEGYFSSGSARINVAGGGGSTPSPPSTPSPPTTPSPPPVTPPPSGGGSCAARWGQCGGSGWNGATCCSAGTCQAQNQWYSQCL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more GH11_dom, Cellulose-bd_dom_fun, Cellulose-bd_dom_fun, GH11_dom, Cellulose-bd_dom_fun, Cellulose-bd_dom_fun that are essential for its biological function; 2. The protein should belong to Glyco_hydro_11, Glyco_hydro_11, Glyco_hydro_11, Glyco_hydro_11, Glyco_hydro_11, Glyco_hydro_11 that shares evolutionary origin and functional similarity; 3. The protein should be classified within CBD_sf, ConA-like_dom_sf, GH11/12 sharing conserved structural features; 4. The protein must have GH11_AS_2 that is conserved among related catalytic enzymes. The designed protein sequence is ", "reference": "MVCFSSLFVAASAIAGVFASPVDHEQLAKRQSTPSSQGTHDGYFYSWWTDGGAAATYTNLAGGEYSVSWSNGGNLVGGKGWNPGSARTITYSGTYNPNGNSYLAVYGWTRNPQPWLTPLVVEYYVVENFGTYNPSSGATARGQVTHDGALYRLFESTRTNQPSIDGTATFQQYWAVRDVKRTGGTVNMATFFNAWTAAGMRLGTHNYQVVATEGYFSSGSARINVAGGGGSTPSPPSTPSPPTTPSPPPVTPPPSGGGSCAARWGQCGGSGWNGATCCSAGTCQAQNQWYSQCL" }, { "InterPro": [ { "InterPro-ID": "IPR018208", "InterPro-Name": "GH11_AS_1", "InterPro-Type": "ACTIVE_SITE", "Beg": 111, "End": 121 }, { "InterPro-ID": "IPR001137", "InterPro-Name": "Glyco_hydro_11", "InterPro-Type": "FAMILY", "Beg": 101, "End": 110 }, { "InterPro-ID": "IPR001137", "InterPro-Name": "Glyco_hydro_11", "InterPro-Type": "FAMILY", "Beg": 111, "End": 121 }, { "InterPro-ID": "IPR001137", "InterPro-Name": "Glyco_hydro_11", "InterPro-Type": "FAMILY", "Beg": 164, "End": 173 }, { "InterPro-ID": "IPR001137", "InterPro-Name": "Glyco_hydro_11", "InterPro-Type": "FAMILY", "Beg": 159, "End": 164 }, { "InterPro-ID": "IPR001137", "InterPro-Name": "Glyco_hydro_11", "InterPro-Type": "FAMILY", "Beg": 187, "End": 195 }, { "InterPro-ID": "IPR013320", "InterPro-Name": "ConA-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 28, "End": 216 }, { "InterPro-ID": "IPR013319", "InterPro-Name": "GH11/12", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 27, "End": 219 }, { "InterPro-ID": "IPR001137", "InterPro-Name": "Glyco_hydro_11", "InterPro-Type": "FAMILY", "Beg": 1, "End": 218 }, { "InterPro-ID": "IPR033123", "InterPro-Name": "GH11_dom", "InterPro-Type": "DOMAIN", "Beg": 28, "End": 218 }, { "InterPro-ID": "IPR033123", "InterPro-Name": "GH11_dom", "InterPro-Type": "DOMAIN", "Beg": 37, "End": 215 } ], "response#1": "MVSFSTLLTACTAITGALGTPDLDRRQNVTPNAQGTHNGYFYSWWSDGQSPVTYTNSAGGSYSVEWSSGGNLVGGKGWNPGSAKEIRYSASWQPTNNSNSYLTIYGWTRSPLVEYYIVESHGEYNPGSSAEPRGEIEAHGSIYKLYESTRVQQPSIDGTQTFQQYWAIRQTHRTSGTVTTGTFFNAWAAAGMPIGQHNYMIVATEAYNSAGRASVVVETPP", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more GH11_dom, GH11_dom that are essential for its biological function; 2. The protein should belong to Glyco_hydro_11, Glyco_hydro_11, Glyco_hydro_11, Glyco_hydro_11, Glyco_hydro_11, Glyco_hydro_11 that shares evolutionary origin and functional similarity; 3. The protein should be classified within ConA-like_dom_sf, GH11/12 sharing conserved structural features; 4. The protein must have GH11_AS_1 that is conserved among related catalytic enzymes. The designed protein sequence is ", "reference": "MVSFSTLLTACTAITGALGTPDLDRRQNVTPNAQGTHNGYFYSWWSDGQSPVTYTNSAGGSYSVEWSSGGNLVGGKGWNPGSAKEIRYSASWQPTNNSNSYLTIYGWTRSPLVEYYIVESHGEYNPGSSAEPRGEIEAHGSIYKLYESTRVQQPSIDGTQTFQQYWAIRQTHRTSGTVTTGTFFNAWAAAGMPIGQHNYMIVATEAYNSAGRASVVVETPP" }, { "InterPro": [ { "InterPro-ID": "IPR001137", "InterPro-Name": "Glyco_hydro_11", "InterPro-Type": "FAMILY", "Beg": 4, "End": 218 }, { "InterPro-ID": "IPR013319", "InterPro-Name": "GH11/12", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 32, "End": 221 }, { "InterPro-ID": "IPR001137", "InterPro-Name": "Glyco_hydro_11", "InterPro-Type": "FAMILY", "Beg": 104, "End": 113 }, { "InterPro-ID": "IPR001137", "InterPro-Name": "Glyco_hydro_11", "InterPro-Type": "FAMILY", "Beg": 114, "End": 124 }, { "InterPro-ID": "IPR001137", "InterPro-Name": "Glyco_hydro_11", "InterPro-Type": "FAMILY", "Beg": 164, "End": 173 }, { "InterPro-ID": "IPR001137", "InterPro-Name": "Glyco_hydro_11", "InterPro-Type": "FAMILY", "Beg": 187, "End": 195 }, { "InterPro-ID": "IPR033119", "InterPro-Name": "GH11_AS_2", "InterPro-Type": "ACTIVE_SITE", "Beg": 202, "End": 213 }, { "InterPro-ID": "IPR013320", "InterPro-Name": "ConA-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 33, "End": 219 }, { "InterPro-ID": "IPR033123", "InterPro-Name": "GH11_dom", "InterPro-Type": "DOMAIN", "Beg": 32, "End": 218 }, { "InterPro-ID": "IPR033123", "InterPro-Name": "GH11_dom", "InterPro-Type": "DOMAIN", "Beg": 42, "End": 216 } ], "response#1": "MLKSLVVLLLTSRVIAFPTLDTDQTAALHKPQATPNSQGTHGGFFYYWWSDGQSPAAYTNLDGGSYCLRWESGGNLIGGKGWSPGTDNRTIQISGTFQGVENSYLAVYGWLETPKVEYYIVEYHGVFNPAYDAQILGTVICDGSVYDISRSTRVSSGGTKILPRYWSVRRNKRTGGTVQTGCHFDAWRSTGLSAADHGFQIVATEGYFSSGFAEMTVADTSAEE", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more GH11_dom, GH11_dom that are essential for its biological function; 2. The protein should belong to Glyco_hydro_11, Glyco_hydro_11, Glyco_hydro_11, Glyco_hydro_11, Glyco_hydro_11 that shares evolutionary origin and functional similarity; 3. The protein should be classified within GH11/12, ConA-like_dom_sf sharing conserved structural features; 4. The protein must have GH11_AS_2 that is conserved among related catalytic enzymes. The designed protein sequence is ", "reference": "MLKSLVVLLLTSRVIAFPTLDTDQTAALHKPQATPNSQGTHGGFFYYWWSDGQSPAAYTNLDGGSYCLRWESGGNLIGGKGWSPGTDNRTIQISGTFQGVENSYLAVYGWLETPKVEYYIVEYHGVFNPAYDAQILGTVICDGSVYDISRSTRVSSGGTKILPRYWSVRRNKRTGGTVQTGCHFDAWRSTGLSAADHGFQIVATEGYFSSGFAEMTVADTSAEE" }, { "InterPro": [ { "InterPro-ID": "IPR050956", "InterPro-Name": "2C_system_His_kinase", "InterPro-Type": "FAMILY", "Beg": 65, "End": 757 }, { "InterPro-ID": "IPR001789", "InterPro-Name": "Sig_transdc_resp-reg_receiver", "InterPro-Type": "DOMAIN", "Beg": 611, "End": 769 }, { "InterPro-ID": "IPR001789", "InterPro-Name": "Sig_transdc_resp-reg_receiver", "InterPro-Type": "DOMAIN", "Beg": 610, "End": 765 }, { "InterPro-ID": "IPR001789", "InterPro-Name": "Sig_transdc_resp-reg_receiver", "InterPro-Type": "DOMAIN", "Beg": 612, "End": 689 }, { "InterPro-ID": "IPR011006", "InterPro-Name": "CheY-like_superfamily", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 608, "End": 768 } ], "response#1": "MGSDLKARLKAKFSRRSSTSGSVKSGHSHSHGETQLSQRDESRSLASTDNHSRPASVRLDPQSSSNLGAPAPAPDADEVPVRIVISPEDSTATSSSTASTLPSEEVQPQESVTRDPSSQLSAAPKRRAASDGPGNDLHHPMAATTSSLASINENQTLVDASIAASPPATKLPPSVSTSARNTAASSAAAAAAASAAVAVTAAAAAADPDNDDDDDDHLDPLHRGPAASDVLTPAPATAPAPVPATLSASSIARPTGPPRRQSLLPNRQDALIKTLLQAANINEADLTADHLLSINANMVTRKIWVKRAGASATLITINEDDLVDDVRDMILKKYTNSLGRHFDAPDLTLRIFPREERQERLLGPEEPMGRTIDAYFPGGQTVDEALVIDIPTRRTPRPSPRGAVSHPTAVYYAHDTGRPSEAGEGYFPPVGAIPSPNLEVPGAAPNGGPPPPHAIHIQHTGHLPHSISILGTGQVPPIPSPGRSHAYKTRPNRPQLGRTHTSSPTFINGVPSNVGGPPTAHPVHSSFHPRLPPSRTQSNASAESAAIVPPAPPLATPPAPEIPSAIQRISTPPPRIASPRPSSARPARKKIAPAHPVLPAGMLAGGVPPINVLIVEDNPINLKLLEAFVKRLKVRWKTAMNGRDAVKKWKGGGFHLVLMDIQLPIMNGLDATKEIRRLERVNSIGVFSSSASGVFSGSVTSEPEGTEGDIEDKDRLANIELFKSPVIIVALTASSLQSDRHEALAAGCNDFLTKPVNFVWLERKVMEWGCMQALIDFDGWRQWKDFAQDAEENDAAKKAAGVKAKSKKNRLSVTTAAA", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Sig_transdc_resp-reg_receiver, Sig_transdc_resp-reg_receiver, Sig_transdc_resp-reg_receiver that are essential for its biological function; 2. The protein should belong to 2C_system_His_kinase that shares evolutionary origin and functional similarity; 3. The protein should be classified within CheY-like_superfamily sharing conserved structural features. The designed protein sequence is ", "reference": "MGSDLKARLKAKFSRRSSTSGSVKSGHSHSHGETQLSQRDESRSLASTDNHSRPASVRLDPQSSSNLGAPAPAPDADEVPVRIVISPEDSTATSSSTASTLPSEEVQPQESVTRDPSSQLSAAPKRRAASDGPGNDLHHPMAATTSSLASINENQTLVDASIAASPPATKLPPSVSTSARNTAASSAAAAAAASAAVAVTAAAAAADPDNDDDDDDHLDPLHRGPAASDVLTPAPATAPAPVPATLSASSIARPTGPPRRQSLLPNRQDALIKTLLQAANINEADLTADHLLSINANMVTRKIWVKRAGASATLITINEDDLVDDVRDMILKKYTNSLGRHFDAPDLTLRIFPREERQERLLGPEEPMGRTIDAYFPGGQTVDEALVIDIPTRRTPRPSPRGAVSHPTAVYYAHDTGRPSEAGEGYFPPVGAIPSPNLEVPGAAPNGGPPPPHAIHIQHTGHLPHSISILGTGQVPPIPSPGRSHAYKTRPNRPQLGRTHTSSPTFINGVPSNVGGPPTAHPVHSSFHPRLPPSRTQSNASAESAAIVPPAPPLATPPAPEIPSAIQRISTPPPRIASPRPSSARPARKKIAPAHPVLPAGMLAGGVPPINVLIVEDNPINLKLLEAFVKRLKVRWKTAMNGRDAVKKWKGGGFHLVLMDIQLPIMNGLDATKEIRRLERVNSIGVFSSSASGVFSGSVTSEPEGTEGDIEDKDRLANIELFKSPVIIVALTASSLQSDRHEALAAGCNDFLTKPVNFVWLERKVMEWGCMQALIDFDGWRQWKDFAQDAEENDAAKKAAGVKAKSKKNRLSVTTAAA" }, { "InterPro": [ { "InterPro-ID": "IPR033123", "InterPro-Name": "GH11_dom", "InterPro-Type": "DOMAIN", "Beg": 43, "End": 231 }, { "InterPro-ID": "IPR033123", "InterPro-Name": "GH11_dom", "InterPro-Type": "DOMAIN", "Beg": 52, "End": 220 }, { "InterPro-ID": "IPR013319", "InterPro-Name": "GH11/12", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 43, "End": 227 }, { "InterPro-ID": "IPR013320", "InterPro-Name": "ConA-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 42, "End": 222 }, { "InterPro-ID": "IPR018208", "InterPro-Name": "GH11_AS_1", "InterPro-Type": "ACTIVE_SITE", "Beg": 124, "End": 134 }, { "InterPro-ID": "IPR001137", "InterPro-Name": "Glyco_hydro_11", "InterPro-Type": "FAMILY", "Beg": 1, "End": 220 }, { "InterPro-ID": "IPR001137", "InterPro-Name": "Glyco_hydro_11", "InterPro-Type": "FAMILY", "Beg": 114, "End": 123 }, { "InterPro-ID": "IPR001137", "InterPro-Name": "Glyco_hydro_11", "InterPro-Type": "FAMILY", "Beg": 200, "End": 208 }, { "InterPro-ID": "IPR001137", "InterPro-Name": "Glyco_hydro_11", "InterPro-Type": "FAMILY", "Beg": 172, "End": 177 }, { "InterPro-ID": "IPR001137", "InterPro-Name": "Glyco_hydro_11", "InterPro-Type": "FAMILY", "Beg": 152, "End": 158 }, { "InterPro-ID": "IPR001137", "InterPro-Name": "Glyco_hydro_11", "InterPro-Type": "FAMILY", "Beg": 177, "End": 186 }, { "InterPro-ID": "IPR001137", "InterPro-Name": "Glyco_hydro_11", "InterPro-Type": "FAMILY", "Beg": 124, "End": 134 } ], "response#1": "MVSFKSLLLAASAFTAVLGRPFDSFDGPDVNITDADELLVRRQVTANSEGTHNGYFYSWWSDGGGQVTYTMGAGSRYSVTWKDTGNFVGGKGWNPGTGRTINYGGSFSPQGNGYLAVYGWTRNPLIEYYVVESYGTYNPGSGGQLKGTVTTDGGTYNVYVSTRTNQPSIDGTRTFQQYWSVRTSKRVGGAVTMQNHFNAWAQFGMNLGAHYYQIVATEGNGDFVGTEIWGLARGCRR", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more GH11_dom, GH11_dom that are essential for its biological function; 2. The protein should belong to Glyco_hydro_11, Glyco_hydro_11, Glyco_hydro_11, Glyco_hydro_11, Glyco_hydro_11, Glyco_hydro_11, Glyco_hydro_11 that shares evolutionary origin and functional similarity; 3. The protein should be classified within GH11/12, ConA-like_dom_sf sharing conserved structural features; 4. The protein must have GH11_AS_1 that is conserved among related catalytic enzymes. The designed protein sequence is ", "reference": "MVSFKSLLLAASAFTAVLGRPFDSFDGPDVNITDADELLVRRQVTANSEGTHNGYFYSWWSDGGGQVTYTMGAGSRYSVTWKDTGNFVGGKGWNPGTGRTINYGGSFSPQGNGYLAVYGWTRNPLIEYYVVESYGTYNPGSGGQLKGTVTTDGGTYNVYVSTRTNQPSIDGTRTFQQYWSVRTSKRVGGAVTMQNHFNAWAQFGMNLGAHYYQIVATEGNGDFVGTEIWGLARGCRR" }, { "InterPro": [ { "InterPro-ID": "IPR036188", "InterPro-Name": "FAD/NAD-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 229, "End": 478 }, { "InterPro-ID": "IPR050775", "InterPro-Name": "FAD-binding_Monooxygenases", "InterPro-Type": "FAMILY", "Beg": 56, "End": 653 }, { "InterPro-ID": "IPR036188", "InterPro-Name": "FAD/NAD-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 76, "End": 361 }, { "InterPro-ID": "IPR023753", "InterPro-Name": "FAD/NAD-binding_dom", "InterPro-Type": "DOMAIN", "Beg": 79, "End": 302 }, { "InterPro-ID": "IPR036188", "InterPro-Name": "FAD/NAD-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 78, "End": 319 }, { "InterPro-ID": "IPR036188", "InterPro-Name": "FAD/NAD-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 446, "End": 652 } ], "response#1": "MAPSAEGASGAPTPEDLKLHQLSQKYTAEAAKRFRPEGLGQFIRLKEVGNERFRALAEDPWVDHAALNAKEPVKDGSRYKFIILGAGYGGLLYAVRLAEAGLASGPDDILMVDAAGGFGGTWWWNRYPGLHCDVESYSYMPLLEETGYIPKSKYAAGPELLEHAYRIATQWKLHDKALFRSNVKTIRWDDESRLWSLEVTEGRGPGQQSRELKLQARYVLLASGILTNPQVPKIPGLETFTGPVFHTARWNYDVTGGSPTDEALNRLEGKRVGIIGTGATAIQVVPKLAKYAKELYVFQRTPSGVWWRGQRPTDPVEWKTKIARKKGWQRERMLNLDSYLTDAAEEGQENMVADGWTEMPAFSAVIGSPRHGIVEPTPEKIAEHLGRLYKLDLPHAEQVRARTDSIVKDPKTAAKLKAWYPTWCKRPTFSDEYLQTFNLPNVHLVDTDGKGVDAANPSGLVVADKEYPLDILVLSTGYVTPSIGGGSPAVRTGVDIYGRGGKSLDDKWQTHGAATLHGVCSNGFPNLFFTPLSQSSQAANNAFTLDVGTEHIVQVIKTAEDRVDGDALVEVTSEAEEAWSFEIMKHAGWFASVTGCTPGYITSEGEALRKSEDPMEMAKRARSGNLSQGMASYMKLLQEYRADGSLKGFDISSRA", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more FAD/NAD-binding_dom that are essential for its biological function; 2. The protein should belong to FAD-binding_Monooxygenases that shares evolutionary origin and functional similarity; 3. The protein should be classified within FAD/NAD-bd_sf, FAD/NAD-bd_sf, FAD/NAD-bd_sf, FAD/NAD-bd_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MAPSAEGASGAPTPEDLKLHQLSQKYTAEAAKRFRPEGLGQFIRLKEVGNERFRALAEDPWVDHAALNAKEPVKDGSRYKFIILGAGYGGLLYAVRLAEAGLASGPDDILMVDAAGGFGGTWWWNRYPGLHCDVESYSYMPLLEETGYIPKSKYAAGPELLEHAYRIATQWKLHDKALFRSNVKTIRWDDESRLWSLEVTEGRGPGQQSRELKLQARYVLLASGILTNPQVPKIPGLETFTGPVFHTARWNYDVTGGSPTDEALNRLEGKRVGIIGTGATAIQVVPKLAKYAKELYVFQRTPSGVWWRGQRPTDPVEWKTKIARKKGWQRERMLNLDSYLTDAAEEGQENMVADGWTEMPAFSAVIGSPRHGIVEPTPEKIAEHLGRLYKLDLPHAEQVRARTDSIVKDPKTAAKLKAWYPTWCKRPTFSDEYLQTFNLPNVHLVDTDGKGVDAANPSGLVVADKEYPLDILVLSTGYVTPSIGGGSPAVRTGVDIYGRGGKSLDDKWQTHGAATLHGVCSNGFPNLFFTPLSQSSQAANNAFTLDVGTEHIVQVIKTAEDRVDGDALVEVTSEAEEAWSFEIMKHAGWFASVTGCTPGYITSEGEALRKSEDPMEMAKRARSGNLSQGMASYMKLLQEYRADGSLKGFDISSRA" }, { "InterPro": [ { "InterPro-ID": "IPR011009", "InterPro-Name": "Kinase-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 5, "End": 338 }, { "InterPro-ID": "IPR000719", "InterPro-Name": "Prot_kinase_dom", "InterPro-Type": "DOMAIN", "Beg": 20, "End": 299 }, { "InterPro-ID": "IPR008271", "InterPro-Name": "Ser/Thr_kinase_AS", "InterPro-Type": "ACTIVE_SITE", "Beg": 137, "End": 149 }, { "InterPro-ID": "IPR008352", "InterPro-Name": "MAPK_p38-like", "InterPro-Type": "FAMILY", "Beg": 184, "End": 194 }, { "InterPro-ID": "IPR008352", "InterPro-Name": "MAPK_p38-like", "InterPro-Type": "FAMILY", "Beg": 261, "End": 274 }, { "InterPro-ID": "IPR008352", "InterPro-Name": "MAPK_p38-like", "InterPro-Type": "FAMILY", "Beg": 277, "End": 285 }, { "InterPro-ID": "IPR008352", "InterPro-Name": "MAPK_p38-like", "InterPro-Type": "FAMILY", "Beg": 298, "End": 308 }, { "InterPro-ID": "IPR017441", "InterPro-Name": "Protein_kinase_ATP_BS", "InterPro-Type": "BINDING_SITE", "Beg": 26, "End": 50 }, { "InterPro-ID": "IPR050117", "InterPro-Name": "MAP_kinase", "InterPro-Type": "FAMILY", "Beg": 18, "End": 301 }, { "InterPro-ID": "IPR038783", "InterPro-Name": "MAPK_Sty1/Hog1", "InterPro-Type": "FAMILY", "Beg": 9, "End": 336 }, { "InterPro-ID": "IPR003527", "InterPro-Name": "MAP_kinase_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 55, "End": 153 } ], "response#1": "MAEFIRAQIFGTTFEITSRYTDLQPVGMGAFGLVCSAKDQLTGQPVAIKKIMKPFSTPVLSKRTYRELKLLKHLKHENVISLSDIFISPLEDIYFVTELLGTDLHRLLTSRPLEKQFIQYFLYQILRGLKYVHSAGVIHRDLKPSNILVNENCDLKICDFGLARIQDPQMTGYVSTRYYRAPEIMLTWQKYDVEVDIWSAGCIFAEMLEGKPLFPGKDHVNQFSIITELLGSPPEDVIHTICSENTLRFVQSLPKRERIPLSQKFKNADPAAVDLLERMLVFDPKKRISAAQALAHEYLAPYHDPSDEPVAAEKFDWSFNDADLPVDTWKIMMYSEILDYHNVDQNDTPL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Prot_kinase_dom that are essential for its biological function; 2. The protein should belong to MAPK_p38-like, MAPK_p38-like, MAPK_p38-like, MAPK_p38-like, MAP_kinase, MAPK_Sty1/Hog1 that shares evolutionary origin and functional similarity; 3. The protein should be classified within Kinase-like_dom_sf sharing conserved structural features; 4. The protein should contain MAP_kinase_CS that is preserved across related proteins; 5. The protein must have Ser/Thr_kinase_AS that is conserved among related catalytic enzymes; 6. The protein should include a Protein_kinase_ATP_BS that enables ligand binding under diverse conditions. The designed protein sequence is ", "reference": "MAEFIRAQIFGTTFEITSRYTDLQPVGMGAFGLVCSAKDQLTGQPVAIKKIMKPFSTPVLSKRTYRELKLLKHLKHENVISLSDIFISPLEDIYFVTELLGTDLHRLLTSRPLEKQFIQYFLYQILRGLKYVHSAGVIHRDLKPSNILVNENCDLKICDFGLARIQDPQMTGYVSTRYYRAPEIMLTWQKYDVEVDIWSAGCIFAEMLEGKPLFPGKDHVNQFSIITELLGSPPEDVIHTICSENTLRFVQSLPKRERIPLSQKFKNADPAAVDLLERMLVFDPKKRISAAQALAHEYLAPYHDPSDEPVAAEKFDWSFNDADLPVDTWKIMMYSEILDYHNVDQNDTPL" }, { "InterPro": [ { "InterPro-ID": "IPR013087", "InterPro-Name": "Znf_C2H2_type", "InterPro-Type": "DOMAIN", "Beg": 385, "End": 413 }, { "InterPro-ID": "IPR050589", "InterPro-Name": "Ikaros_C2H2-ZF", "InterPro-Type": "FAMILY", "Beg": 378, "End": 436 }, { "InterPro-ID": "IPR013087", "InterPro-Name": "Znf_C2H2_type", "InterPro-Type": "DOMAIN", "Beg": 385, "End": 408 }, { "InterPro-ID": "IPR013087", "InterPro-Name": "Znf_C2H2_type", "InterPro-Type": "DOMAIN", "Beg": 414, "End": 436 }, { "InterPro-ID": "IPR013087", "InterPro-Name": "Znf_C2H2_type", "InterPro-Type": "DOMAIN", "Beg": 416, "End": 436 }, { "InterPro-ID": "IPR036236", "InterPro-Name": "Znf_C2H2_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 383, "End": 436 }, { "InterPro-ID": "IPR013087", "InterPro-Name": "Znf_C2H2_type", "InterPro-Type": "DOMAIN", "Beg": 387, "End": 408 } ], "response#1": "MEAAGFLYYSPDPQGRQQKQHGHHGHFLAQPNAAYTISASPQLLAPTPIHFPSQLVLGGRGVPLTITPSASPSLMEPYRDMCSESATTDLLFNPATPPLTHSAVSTPSLSYAMPTPISNHGWSSEEPVIATVSLSDIHLPSTPADYFPPGLVAPSILKSNASPPPSISLNDLHCPALSPCSSQDSFNESDCCDPRELTIQSPTPVEIKPDILFPPMASLSGDDDQFLFGGNVESFLPLASKVTPYMAGDYNEELSDLGDSEDDFIQNFSESVFSNKRMRFDDDSENEQLPSPPMSTSSSRQGSVAPIKVLKRKLLKVKKEDTPEEMSEEQRLRSFKFGSIDSACSSEPSSPCSEKHSHMVGHPISPHVIRRGRKQSLTEDPSKTFVCHLCTRRFRRQEHLKRHFRSLHTEDKPFACGECGKKFSRSDNLTQHSRIHGTGAVVLGVLTEGEVPVLGSQFMEDESMHSPQPFIVVDSMTAASGEIKDKSSDDKKSRKKRKRSDE", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Znf_C2H2_type, Znf_C2H2_type, Znf_C2H2_type, Znf_C2H2_type, Znf_C2H2_type that are essential for its biological function; 2. The protein should belong to Ikaros_C2H2-ZF that shares evolutionary origin and functional similarity; 3. The protein should be classified within Znf_C2H2_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MEAAGFLYYSPDPQGRQQKQHGHHGHFLAQPNAAYTISASPQLLAPTPIHFPSQLVLGGRGVPLTITPSASPSLMEPYRDMCSESATTDLLFNPATPPLTHSAVSTPSLSYAMPTPISNHGWSSEEPVIATVSLSDIHLPSTPADYFPPGLVAPSILKSNASPPPSISLNDLHCPALSPCSSQDSFNESDCCDPRELTIQSPTPVEIKPDILFPPMASLSGDDDQFLFGGNVESFLPLASKVTPYMAGDYNEELSDLGDSEDDFIQNFSESVFSNKRMRFDDDSENEQLPSPPMSTSSSRQGSVAPIKVLKRKLLKVKKEDTPEEMSEEQRLRSFKFGSIDSACSSEPSSPCSEKHSHMVGHPISPHVIRRGRKQSLTEDPSKTFVCHLCTRRFRRQEHLKRHFRSLHTEDKPFACGECGKKFSRSDNLTQHSRIHGTGAVVLGVLTEGEVPVLGSQFMEDESMHSPQPFIVVDSMTAASGEIKDKSSDDKKSRKKRKRSDE" }, { "InterPro": [ { "InterPro-ID": "IPR008775", "InterPro-Name": "Phytyl_CoA_dOase-like", "InterPro-Type": "FAMILY", "Beg": 17, "End": 229 } ], "response#1": "MERIPASAGPEAIFEAFRRDGIIVIEGFLTPDQVQRFSSEVQPGLDELTVGAPEHDEAAQTATVMDEMIGEKTKRLGQLVTRSAVFRHELLEHELMHALLEKVFVEGPMDGYWMNASEVIEIAPGSNAQPIHRDQELYDVWNRAGPAMPEAICNFISALTPFTALNGATQVAPGTHRDFTSDHLLDRDFQGRSDLKTIPAVMNPGDCIFFSGKILHGGGANHTADELRRGLAMSFIRRILTPEEAHPLSVSREIVDTMTYRGQAMLGFRSQWPVIEGVPNFYWTHQGSEIGSHIGLKEKTSGSVVL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Phytyl_CoA_dOase-like that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MERIPASAGPEAIFEAFRRDGIIVIEGFLTPDQVQRFSSEVQPGLDELTVGAPEHDEAAQTATVMDEMIGEKTKRLGQLVTRSAVFRHELLEHELMHALLEKVFVEGPMDGYWMNASEVIEIAPGSNAQPIHRDQELYDVWNRAGPAMPEAICNFISALTPFTALNGATQVAPGTHRDFTSDHLLDRDFQGRSDLKTIPAVMNPGDCIFFSGKILHGGGANHTADELRRGLAMSFIRRILTPEEAHPLSVSREIVDTMTYRGQAMLGFRSQWPVIEGVPNFYWTHQGSEIGSHIGLKEKTSGSVVL" }, { "InterPro": [ { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 308, "End": 321 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 414, "End": 423 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 423, "End": 434 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 343, "End": 354 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 413, "End": 423 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 88, "End": 109 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 383, "End": 407 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 342, "End": 360 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 299, "End": 325 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 64, "End": 83 }, { "InterPro-ID": "IPR002401", "InterPro-Name": "Cyt_P450_E_grp-I", "InterPro-Type": "FAMILY", "Beg": 423, "End": 446 }, { "InterPro-ID": "IPR036396", "InterPro-Name": "Cyt_P450_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 27, "End": 496 }, { "InterPro-ID": "IPR036396", "InterPro-Name": "Cyt_P450_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 36, "End": 481 }, { "InterPro-ID": "IPR050364", "InterPro-Name": "Cytochrome_P450_fung", "InterPro-Type": "FAMILY", "Beg": 13, "End": 494 }, { "InterPro-ID": "IPR017972", "InterPro-Name": "Cyt_P450_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 416, "End": 425 }, { "InterPro-ID": "IPR001128", "InterPro-Name": "Cyt_P450", "InterPro-Type": "FAMILY", "Beg": 36, "End": 456 } ], "response#1": "MYYRETMLAFVPYLAVFVACYGLVYYRRKRQRLPLPPGPPQLPLVGNLYQIPEMNPWRTYREWHQKYGPIITVKSGLTNTIILGSHKAARDLLDKRNRNYGSRPHFILIGDFIYGGNQTSLLPTGQRWRIHRRILSAFGNVRTSQRYRILYDAESKRLLREILHGGDFFEPFHHYFVRILFALTYGKRVTGSHDPEARDVIEIVDVVLKEASRSSVPEAFPILNSLPGALAPWKRRAQLLFEQHSRLFDNHMNAALANKPWNFCKQALRLKASSEVDRVELNFILGSITEATHSGSMVLGVFIMANILHPDAVRWVQEEIDRVIGPDRLPSFDDMAKLPYLNAYLLEVMRWRPITPGGMPHASFQDDEYMGYHIPKGTTVVANHWSMDFDESVFTDPYEFRPQRWIEDPNLPSIAFGFGTRICPGRHIAESSIFIVAARLLWSFNFDYAYEDGKRQEIDSWNMTQGLDSGPMPFKASFKIRSPKHQEVMDRECGVSDLDIDAILDKIGADFL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Cyt_P450, Cyt_P450, Cyt_P450, Cyt_P450, Cyt_P450_E_grp-I, Cyt_P450_E_grp-I, Cyt_P450_E_grp-I, Cyt_P450_E_grp-I, Cyt_P450_E_grp-I, Cyt_P450_E_grp-I, Cyt_P450_E_grp-I, Cytochrome_P450_fung, Cyt_P450 that shares evolutionary origin and functional similarity; 2. The protein should be classified within Cyt_P450_sf, Cyt_P450_sf sharing conserved structural features; 3. The protein should contain Cyt_P450_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MYYRETMLAFVPYLAVFVACYGLVYYRRKRQRLPLPPGPPQLPLVGNLYQIPEMNPWRTYREWHQKYGPIITVKSGLTNTIILGSHKAARDLLDKRNRNYGSRPHFILIGDFIYGGNQTSLLPTGQRWRIHRRILSAFGNVRTSQRYRILYDAESKRLLREILHGGDFFEPFHHYFVRILFALTYGKRVTGSHDPEARDVIEIVDVVLKEASRSSVPEAFPILNSLPGALAPWKRRAQLLFEQHSRLFDNHMNAALANKPWNFCKQALRLKASSEVDRVELNFILGSITEATHSGSMVLGVFIMANILHPDAVRWVQEEIDRVIGPDRLPSFDDMAKLPYLNAYLLEVMRWRPITPGGMPHASFQDDEYMGYHIPKGTTVVANHWSMDFDESVFTDPYEFRPQRWIEDPNLPSIAFGFGTRICPGRHIAESSIFIVAARLLWSFNFDYAYEDGKRQEIDSWNMTQGLDSGPMPFKASFKIRSPKHQEVMDRECGVSDLDIDAILDKIGADFL" }, { "InterPro": [ { "InterPro-ID": "IPR036291", "InterPro-Name": "NAD(P)-bd_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 652, "End": 923 }, { "InterPro-ID": "IPR010080", "InterPro-Name": "Thioester_reductase-like_dom", "InterPro-Type": "DOMAIN", "Beg": 652, "End": 948 }, { "InterPro-ID": "IPR009081", "InterPro-Name": "PP-bd_ACP", "InterPro-Type": "DOMAIN", "Beg": 542, "End": 604 }, { "InterPro-ID": "IPR009081", "InterPro-Name": "PP-bd_ACP", "InterPro-Type": "DOMAIN", "Beg": 534, "End": 611 }, { "InterPro-ID": "IPR045851", "InterPro-Name": "AMP-bd_C_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 420, "End": 524 }, { "InterPro-ID": "IPR036736", "InterPro-Name": "ACP-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 526, "End": 612 }, { "InterPro-ID": "IPR000873", "InterPro-Name": "AMP-dep_synth/lig_dom", "InterPro-Type": "DOMAIN", "Beg": 28, "End": 371 }, { "InterPro-ID": "IPR042099", "InterPro-Name": "ANL_N_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 14, "End": 419 }, { "InterPro-ID": "IPR010080", "InterPro-Name": "Thioester_reductase-like_dom", "InterPro-Type": "DOMAIN", "Beg": 653, "End": 1021 }, { "InterPro-ID": "IPR013120", "InterPro-Name": "Far_NAD-bd", "InterPro-Type": "DOMAIN", "Beg": 655, "End": 898 }, { "InterPro-ID": "IPR036736", "InterPro-Name": "ACP-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 537, "End": 617 } ], "response#1": "MPSHTFNPQAGYDLAVDRNLGLGEIFYNRAQKSHQAIAVCDGGAVLTYGQLHAKAYRLAQELSQWLRLTEKPVGIVVQHGMADVVAQMAVIYAGGSCAPMDPTLPDNQIQGRLKRLDAVCVLTDQANRHRDLGADVLCIDDFDIADLAPEDTLYPVATNLEHCAYLIHTSGTTAEPKAVQIAARSILHVAFYAPLEPVYDTDVVAHANNSSFDVSLFDIWVPLLRGAQIAVINKAVLLDPPMMAREIDRLGITVMATTTAVLNLAAFIYPKAFAKLRLVTIGGEAANVAAIRIILKNGPPAMLFNAYGPTECCVFCLAHQITPADVEHGSIGVSIGKPVGRTITYIAGDEGGESDQGELWIGGPGVSPGYFRQPEKNLAAFSDLGEAMTSLENPVRFYRTGDIVRRRPNGALEYVGRRDHQVKVRGFRIELEAVEAGLLKTGLFSDAVAMRIEMPQNGAGSILAAYVVPTDVSKPPTMDEALESAKSILPHYMVPQLELVPRLPLNRHLKVDRKQLAELFGRRWEDVSPAQPENASQDVRSALVSLWATVLASPLSTYGDDDDFLHLGGTSLQAAMLINQIRHKFDIEVSLLTLYDNTTLGALTSIIKQRLSGQSETLHNEKDSWVADSEIADDLSCPLDRPIDWCRDTEGRVFLTGGTGFVGAFLLADLLHMPQTSQVRCLVRATDAAVGQERLRAALDKYGLWEDGFADKLVAIAGLLEDDYLGMGREQFEEAASWASVVFHLGARVNYAQPYSLHRASNTLGTRNMVRFACAGRTKAIHYVSSIGCFGPTGSILGTTSVREDEPLLPHITALPYDHGYAQSQWVADALLRRLMDRGFPIAIYRPGFIVGHSQTGACNPDDFLSRLIDACREIGCYPQLPNQRKEFVPVDYVNAAILHIAASPASLGHAYHIVPPTRAVSIDMDNSMALVDRAGNSPMRPVSYKEWVERLAATSPKRLLPLQPMLAERVKDGLTRWELYENMPVYETTNTARALQNYPGGLQFPVLDTSLMKRYLDFLEAKG", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Thioester_reductase-like_dom, PP-bd_ACP, PP-bd_ACP, AMP-dep_synth/lig_dom, Thioester_reductase-like_dom, Far_NAD-bd that are essential for its biological function; 2. The protein should be classified within NAD(P)-bd_dom_sf, AMP-bd_C_sf, ACP-like_sf, ANL_N_sf, ACP-like_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MPSHTFNPQAGYDLAVDRNLGLGEIFYNRAQKSHQAIAVCDGGAVLTYGQLHAKAYRLAQELSQWLRLTEKPVGIVVQHGMADVVAQMAVIYAGGSCAPMDPTLPDNQIQGRLKRLDAVCVLTDQANRHRDLGADVLCIDDFDIADLAPEDTLYPVATNLEHCAYLIHTSGTTAEPKAVQIAARSILHVAFYAPLEPVYDTDVVAHANNSSFDVSLFDIWVPLLRGAQIAVINKAVLLDPPMMAREIDRLGITVMATTTAVLNLAAFIYPKAFAKLRLVTIGGEAANVAAIRIILKNGPPAMLFNAYGPTECCVFCLAHQITPADVEHGSIGVSIGKPVGRTITYIAGDEGGESDQGELWIGGPGVSPGYFRQPEKNLAAFSDLGEAMTSLENPVRFYRTGDIVRRRPNGALEYVGRRDHQVKVRGFRIELEAVEAGLLKTGLFSDAVAMRIEMPQNGAGSILAAYVVPTDVSKPPTMDEALESAKSILPHYMVPQLELVPRLPLNRHLKVDRKQLAELFGRRWEDVSPAQPENASQDVRSALVSLWATVLASPLSTYGDDDDFLHLGGTSLQAAMLINQIRHKFDIEVSLLTLYDNTTLGALTSIIKQRLSGQSETLHNEKDSWVADSEIADDLSCPLDRPIDWCRDTEGRVFLTGGTGFVGAFLLADLLHMPQTSQVRCLVRATDAAVGQERLRAALDKYGLWEDGFADKLVAIAGLLEDDYLGMGREQFEEAASWASVVFHLGARVNYAQPYSLHRASNTLGTRNMVRFACAGRTKAIHYVSSIGCFGPTGSILGTTSVREDEPLLPHITALPYDHGYAQSQWVADALLRRLMDRGFPIAIYRPGFIVGHSQTGACNPDDFLSRLIDACREIGCYPQLPNQRKEFVPVDYVNAAILHIAASPASLGHAYHIVPPTRAVSIDMDNSMALVDRAGNSPMRPVSYKEWVERLAATSPKRLLPLQPMLAERVKDGLTRWELYENMPVYETTNTARALQNYPGGLQFPVLDTSLMKRYLDFLEAKG" }, { "InterPro": [ { "InterPro-ID": "IPR001155", "InterPro-Name": "OxRdtase_FMN_N", "InterPro-Type": "DOMAIN", "Beg": 7, "End": 337 }, { "InterPro-ID": "IPR045247", "InterPro-Name": "Oye-like", "InterPro-Type": "FAMILY", "Beg": 4, "End": 360 }, { "InterPro-ID": "IPR013785", "InterPro-Name": "Aldolase_TIM", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1, "End": 370 } ], "response#1": "MDNSSRLFSPLRLGKCQLRHRVAMSPLTRFRADDLSVQMPFAKEYYAQRASVPGTFLVSEATSISRESVGFSNVPGIWNAEQVRAWKEIADDVHCKGSFLFLQLWATGRSATPERLQSGDFDFASSSAVPMEPGGAVPRELTEEDIHDLIARFAEAARRAIDAGMDGIELHAANGYLIDQFTQASCNQRTDRWGGSIENRARFAIEVTRSVVAAVGADRVGVKLSPWGKIQGMGTMQDLVPQFQYLVSELRDMGLAYLRLSNSRWIDGVPQEEEDNSIYVHTWGASRPVLLEGGYDPISAQKEADIRFNGYDAVIAFGRFFISNPDLPFRIKAGVDLQKYNRDTFYTPISEKGYIDYPFSTAFLEEHSSKASLKL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more OxRdtase_FMN_N that are essential for its biological function; 2. The protein should belong to Oye-like that shares evolutionary origin and functional similarity; 3. The protein should be classified within Aldolase_TIM sharing conserved structural features. The designed protein sequence is ", "reference": "MDNSSRLFSPLRLGKCQLRHRVAMSPLTRFRADDLSVQMPFAKEYYAQRASVPGTFLVSEATSISRESVGFSNVPGIWNAEQVRAWKEIADDVHCKGSFLFLQLWATGRSATPERLQSGDFDFASSSAVPMEPGGAVPRELTEEDIHDLIARFAEAARRAIDAGMDGIELHAANGYLIDQFTQASCNQRTDRWGGSIENRARFAIEVTRSVVAAVGADRVGVKLSPWGKIQGMGTMQDLVPQFQYLVSELRDMGLAYLRLSNSRWIDGVPQEEEDNSIYVHTWGASRPVLLEGGYDPISAQKEADIRFNGYDAVIAFGRFFISNPDLPFRIKAGVDLQKYNRDTFYTPISEKGYIDYPFSTAFLEEHSSKASLKL" }, { "InterPro": [ { "InterPro-ID": "IPR036686", "InterPro-Name": "Hydrophobin_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 26, "End": 100 }, { "InterPro-ID": "IPR036686", "InterPro-Name": "Hydrophobin_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 33, "End": 99 }, { "InterPro-ID": "IPR010636", "InterPro-Name": "Cerato-ulmin_hydrophobin", "InterPro-Type": "FAMILY", "Beg": 32, "End": 97 }, { "InterPro-ID": "IPR010636", "InterPro-Name": "Cerato-ulmin_hydrophobin", "InterPro-Type": "FAMILY", "Beg": 1, "End": 98 }, { "InterPro-ID": "IPR010636", "InterPro-Name": "Cerato-ulmin_hydrophobin", "InterPro-Type": "FAMILY", "Beg": 33, "End": 98 } ], "response#1": "MQFLAVAALLFTTALAAPSSDVNGIIRRANAFCPEGLLYTNPLCCDLDVLGVADVDCVVPPAKPSSCKSFGSVCASIGRKPRCCAVPVAGVALLCTDPIPAI", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Cerato-ulmin_hydrophobin, Cerato-ulmin_hydrophobin, Cerato-ulmin_hydrophobin that shares evolutionary origin and functional similarity; 2. The protein should be classified within Hydrophobin_sf, Hydrophobin_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MQFLAVAALLFTTALAAPSSDVNGIIRRANAFCPEGLLYTNPLCCDLDVLGVADVDCVVPPAKPSSCKSFGSVCASIGRKPRCCAVPVAGVALLCTDPIPAI" }, { "InterPro": [ { "InterPro-ID": "IPR002347", "InterPro-Name": "SDR_fam", "InterPro-Type": "FAMILY", "Beg": 131, "End": 147 }, { "InterPro-ID": "IPR002347", "InterPro-Name": "SDR_fam", "InterPro-Type": "FAMILY", "Beg": 11, "End": 28 }, { "InterPro-ID": "IPR002347", "InterPro-Name": "SDR_fam", "InterPro-Type": "FAMILY", "Beg": 179, "End": 196 }, { "InterPro-ID": "IPR002347", "InterPro-Name": "SDR_fam", "InterPro-Type": "FAMILY", "Beg": 219, "End": 239 }, { "InterPro-ID": "IPR002347", "InterPro-Name": "SDR_fam", "InterPro-Type": "FAMILY", "Beg": 86, "End": 97 }, { "InterPro-ID": "IPR002347", "InterPro-Name": "SDR_fam", "InterPro-Type": "FAMILY", "Beg": 157, "End": 176 }, { "InterPro-ID": "IPR020904", "InterPro-Name": "Sc_DH/Rdtase_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 144, "End": 172 }, { "InterPro-ID": "IPR036291", "InterPro-Name": "NAD(P)-bd_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 9, "End": 256 }, { "InterPro-ID": "IPR002347", "InterPro-Name": "SDR_fam", "InterPro-Type": "FAMILY", "Beg": 137, "End": 145 }, { "InterPro-ID": "IPR002347", "InterPro-Name": "SDR_fam", "InterPro-Type": "FAMILY", "Beg": 19, "End": 255 } ], "response#1": "MNPPPSLLDKAAIVTGGSRGIGAAIAIELARRGAHVLITYNTASHKAQLVAEEIQKLGRKATVVQASSTDREGPNRIVQAAVSQYGRIDIIVNNAGMADDCLLQDLTHEFWDRIMDVNLRLPAFLVQAALQHLGPAPRIVNISSLAARAGYNATSVYAASKAALEGMTRAWATELGHRYNVTVNCVNPGPVDTDIMAVDENTDAEVVAYWNAKVKETPAAPRVGTPGDIAQIVAFLCEEGSRWCTGSVVNANGGLVTV", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to SDR_fam, SDR_fam, SDR_fam, SDR_fam, SDR_fam, SDR_fam, SDR_fam, SDR_fam that shares evolutionary origin and functional similarity; 2. The protein should be classified within NAD(P)-bd_dom_sf sharing conserved structural features; 3. The protein should contain Sc_DH/Rdtase_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MNPPPSLLDKAAIVTGGSRGIGAAIAIELARRGAHVLITYNTASHKAQLVAEEIQKLGRKATVVQASSTDREGPNRIVQAAVSQYGRIDIIVNNAGMADDCLLQDLTHEFWDRIMDVNLRLPAFLVQAALQHLGPAPRIVNISSLAARAGYNATSVYAASKAALEGMTRAWATELGHRYNVTVNCVNPGPVDTDIMAVDENTDAEVVAYWNAKVKETPAAPRVGTPGDIAQIVAFLCEEGSRWCTGSVVNANGGLVTV" }, { "InterPro": [ { "InterPro-ID": "IPR029057", "InterPro-Name": "PRTase-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 259, "End": 488 }, { "InterPro-ID": "IPR000836", "InterPro-Name": "PRibTrfase_dom", "InterPro-Type": "DOMAIN", "Beg": 284, "End": 403 }, { "InterPro-ID": "IPR029055", "InterPro-Name": "Ntn_hydrolases_N", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 2, "End": 264 }, { "InterPro-ID": "IPR005854", "InterPro-Name": "PurF", "InterPro-Type": "FAMILY", "Beg": 1, "End": 479 }, { "InterPro-ID": "IPR000836", "InterPro-Name": "PRibTrfase_dom", "InterPro-Type": "DOMAIN", "Beg": 303, "End": 403 }, { "InterPro-ID": "IPR029057", "InterPro-Name": "PRTase-like", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 286, "End": 451 }, { "InterPro-ID": "IPR029055", "InterPro-Name": "Ntn_hydrolases_N", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 2, "End": 424 }, { "InterPro-ID": "IPR017932", "InterPro-Name": "GATase_2_dom", "InterPro-Type": "DOMAIN", "Beg": 2, "End": 241 }, { "InterPro-ID": "IPR035584", "InterPro-Name": "PurF_N", "InterPro-Type": "DOMAIN", "Beg": 2, "End": 273 }, { "InterPro-ID": "IPR005854", "InterPro-Name": "PurF", "InterPro-Type": "FAMILY", "Beg": 1, "End": 492 }, { "InterPro-ID": "IPR005854", "InterPro-Name": "PurF", "InterPro-Type": "FAMILY", "Beg": 2, "End": 479 } ], "response#1": "MCGVLALILANQSSSAANDLHEALYVLQHRGQDAAGIATSTSSGHIHIRKKNGMAADVFQSGARLANLFGSMGIAHLRYPTAGGSANTEAQPFYVNSPYGICFAHNGNLINTVELRRYLDFEIHRHINSDSDSELMLNIFADELSETKKARVNTEDIFNGLSKMYQRCEGAWACTAMLAGFGVIGFRDAYGIRPLVMGSRPSSDGDGLDYMIASESIALDRLGFTNVRDIQPGEAVIVAKGAEPVFCQVAPRKSYTPDLFEYVYFARPDSVIDGISVYQSRQRMGRYLAARLLEVLGPEGIKEIDVVIPVPETSSPAAASVAHALNKPYCAGYIRNPYVFRTFIMPGQATRQKGVRRKLSAVKEEFKNRTILLVDDSIARGTTSREAISMAREAGVKKIIAACCSPEITYPHIYGIDLPSPHEMVAYERDNNDIAQNLGADRIVYQTLEDLQASCAEIARENDFQEPHTFENGVFSGQYVTPVPEGYFALLEKIRGTGRKEALDKSSKRL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more PRibTrfase_dom, PRibTrfase_dom, GATase_2_dom, PurF_N that are essential for its biological function; 2. The protein should belong to PurF, PurF, PurF that shares evolutionary origin and functional similarity; 3. The protein should be classified within PRTase-like, Ntn_hydrolases_N, PRTase-like, Ntn_hydrolases_N sharing conserved structural features. The designed protein sequence is ", "reference": "MCGVLALILANQSSSAANDLHEALYVLQHRGQDAAGIATSTSSGHIHIRKKNGMAADVFQSGARLANLFGSMGIAHLRYPTAGGSANTEAQPFYVNSPYGICFAHNGNLINTVELRRYLDFEIHRHINSDSDSELMLNIFADELSETKKARVNTEDIFNGLSKMYQRCEGAWACTAMLAGFGVIGFRDAYGIRPLVMGSRPSSDGDGLDYMIASESIALDRLGFTNVRDIQPGEAVIVAKGAEPVFCQVAPRKSYTPDLFEYVYFARPDSVIDGISVYQSRQRMGRYLAARLLEVLGPEGIKEIDVVIPVPETSSPAAASVAHALNKPYCAGYIRNPYVFRTFIMPGQATRQKGVRRKLSAVKEEFKNRTILLVDDSIARGTTSREAISMAREAGVKKIIAACCSPEITYPHIYGIDLPSPHEMVAYERDNNDIAQNLGADRIVYQTLEDLQASCAEIARENDFQEPHTFENGVFSGQYVTPVPEGYFALLEKIRGTGRKEALDKSSKRL" }, { "InterPro": [ { "InterPro-ID": "IPR036388", "InterPro-Name": "WH-like_DNA-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 76, "End": 160 }, { "InterPro-ID": "IPR001077", "InterPro-Name": "O_MeTrfase_dom", "InterPro-Type": "DOMAIN", "Beg": 210, "End": 398 }, { "InterPro-ID": "IPR029063", "InterPro-Name": "SAM-dependent_MTases_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 208, "End": 400 }, { "InterPro-ID": "IPR016461", "InterPro-Name": "COMT-like", "InterPro-Type": "FAMILY", "Beg": 75, "End": 421 }, { "InterPro-ID": "IPR029063", "InterPro-Name": "SAM-dependent_MTases_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 165, "End": 418 }, { "InterPro-ID": "IPR036390", "InterPro-Name": "WH_DNA-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 84, "End": 154 } ], "response#1": "MSTIRGTLSELSRAADAFAHEVDEAGYGDYTFLPDNSPFDLSFLTSKGLEARGSLIAAAEKILRLAKGPQGCLASFADTKGIEMGTIQALTQLEVPDKVPLQGSITYEELAGVIRVAPELLQRLVRLAALAGFLIEDESGAVRHTAMSAVFLRDTAAGDTARFLFDVDMRAYSFFADSLRLDPSGQNIGDGPTALAFQHDSDDQGNRPTIWDILERNPIQRARFHSTMQALGSFPSHLLKHILVAHDWHSIGSLVDVGGSLGHASLVIAENFPEIRITVQDLPDVVERGRSSLPTVPHAERVSFQAHDLFQEQAIIADAYFLRQILHDWPDGDAERIVRCLIPAMRPGAKLLIMDIVVPEPGAISPYMEKYLRTYDVSMFSMFSAKERTVQQLRDLVERCSARLQFQGISCPPGSATSLLSWVYSAE", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more O_MeTrfase_dom that are essential for its biological function; 2. The protein should belong to COMT-like that shares evolutionary origin and functional similarity; 3. The protein should be classified within WH-like_DNA-bd_sf, SAM-dependent_MTases_sf, SAM-dependent_MTases_sf, WH_DNA-bd_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MSTIRGTLSELSRAADAFAHEVDEAGYGDYTFLPDNSPFDLSFLTSKGLEARGSLIAAAEKILRLAKGPQGCLASFADTKGIEMGTIQALTQLEVPDKVPLQGSITYEELAGVIRVAPELLQRLVRLAALAGFLIEDESGAVRHTAMSAVFLRDTAAGDTARFLFDVDMRAYSFFADSLRLDPSGQNIGDGPTALAFQHDSDDQGNRPTIWDILERNPIQRARFHSTMQALGSFPSHLLKHILVAHDWHSIGSLVDVGGSLGHASLVIAENFPEIRITVQDLPDVVERGRSSLPTVPHAERVSFQAHDLFQEQAIIADAYFLRQILHDWPDGDAERIVRCLIPAMRPGAKLLIMDIVVPEPGAISPYMEKYLRTYDVSMFSMFSAKERTVQQLRDLVERCSARLQFQGISCPPGSATSLLSWVYSAE" }, { "InterPro": [ { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 28, "End": 103 }, { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 28, "End": 106 } ], "response#1": "MFSRIAAVSFLALPLLAAATPVLRRGDCNTGPIQCCQSTETAGSAAGSALLGLLGVVVQSVDVVLGLNCSPISVIGVGSGSACDASPVCCENNSVGGIISIGCVPIQL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Hydrophobin, Hydrophobin that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MFSRIAAVSFLALPLLAAATPVLRRGDCNTGPIQCCQSTETAGSAAGSALLGLLGVVVQSVDVVLGLNCSPISVIGVGSGSACDASPVCCENNSVGGIISIGCVPIQL" }, { "InterPro": [ { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 42, "End": 133 }, { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 42, "End": 129 } ], "response#1": "MKFLAVVSLLAATALALPNAGVVHPTFASADKYTLQQAQNKCGEHTTLSCCNHVSKVGDTTAFNYGLLNGLLGNAISGPEGVGILSGCQKISVTALIGVDDLLNKQCQQNVACCQDNKSVATGGLINIATPACVALDSII", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Hydrophobin, Hydrophobin that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MKFLAVVSLLAATALALPNAGVVHPTFASADKYTLQQAQNKCGEHTTLSCCNHVSKVGDTTAFNYGLLNGLLGNAISGPEGVGILSGCQKISVTALIGVDDLLNKQCQQNVACCQDNKSVATGGLINIATPACVALDSII" }, { "InterPro": [ { "InterPro-ID": "IPR016024", "InterPro-Name": "ARM-type_fold", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 769, "End": 1257 }, { "InterPro-ID": "IPR045330", "InterPro-Name": "Trm3/TARBP1", "InterPro-Type": "FAMILY", "Beg": 4, "End": 1571 }, { "InterPro-ID": "IPR029026", "InterPro-Name": "tRNA_m1G_MTases_N", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1422, "End": 1573 }, { "InterPro-ID": "IPR056921", "InterPro-Name": "TARBP1_dom", "InterPro-Type": "DOMAIN", "Beg": 197, "End": 323 }, { "InterPro-ID": "IPR029028", "InterPro-Name": "Alpha/beta_knot_MTases", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1411, "End": 1571 }, { "InterPro-ID": "IPR025806", "InterPro-Name": "Prob_MeTrfase_TARBP1", "InterPro-Type": "FAMILY", "Beg": 1, "End": 1579 }, { "InterPro-ID": "IPR001537", "InterPro-Name": "SpoU_MeTrfase", "InterPro-Type": "DOMAIN", "Beg": 1422, "End": 1563 }, { "InterPro-ID": "IPR044748", "InterPro-Name": "Trm3/TARBP1_C", "InterPro-Type": "DOMAIN", "Beg": 1422, "End": 1566 } ], "response#1": "MERVLADALLTQSREPGELLGALCGGEASAERAETLRLVLQRLEERGAGAGALAKAAHEVARDHLVPLLHASQGGGPARPRVLRAASAALRSCARLAGPELAVTLAEEALRELPSAPAVELLAAVAPCLRAPEDAPLLRRLGRASVELALAGDAPPAVGARLLPALAQSAEPALRAAWDALSSAGPGAEGSTGPELLVLSALAEKLLTNHERHGDLDARLCGRFWRTVQAGLGRAQDGLTRKRARYLLQRAVQVSAELAVDCSCSPQDTKGPSLFWWSEKRKDELLKFWENYILIMEILEGNQIHVIKPALPKLNRLFECAVSEENGCWLFHPSWHTCIYKRMFESENKILAKEGVIHFLELYDVKSLPYSPELSEFITGPLMDALSESCLYSRSPGQPLGSDSPLGLKLQKFLVTYTSLLPEETKSCFLLKLIQRMADRHWCAVPVLFLSRALASIPSCKALGGEGLLALRDVLQRTMITHQVLLRGAAQCYLLQTAMRLVDVEKVSLSDISAFLLSLRQEESLGRGTVLWTELCDWLRVNERYFKQSSLGGSDGQEASLNAYVKNLVQEFVKSPGWEKESSFMPDWLDARLTALMVLLAVDVEGLKTKFREKQRTQNVLRIFLDPLLDALGKLGTNAYMPLLRTDRCLQLLVRLLHSCVPRRPGAQDDEVSTALQGSIMSASESVSQFVLRRLTMNELQDVADLDRCQLYLTVLSELMSLQVKLGWKAGNPISRVLSPLKNACVRHLQEAEDRQEPTLSHQVQRVVSMAALAALCEAVDQYPVLQPDSPNAEPVDRFLSALPLNHVLQKPRSEEQSIGVCPLENGSVFEESLSSKGWGKVVAQYLHDQWVCLSFLLRKHHHLIPSTESDVLEGFLPTAETPVQALQAALDVLTVLPAGRILPVFRCMEVLVPKLLTSEETLCIESFDVAWKIISSLSNTQLTFWPNLKAFVHFVFDHEILTIAAKLKGQVYFKIKEIMCKMIEMSSIKSGVFNILIRHCCQSWLVAASGVSQGSFSSAKDYSELVLEACVFGTVFRRDQRLIQDVQTFIENLGQGCAANVIIENAKREDYYVRICAIKFLCLLDGSDVSHKLFLEALAIKLLDKDESASRSRTRYHENSLQHRVKNRVWQTLLVLFPAFDQNFLHGIIDKVFHAGFTNNQASIKYFIEWLIILILHKFPEFLPKFWACFSYGEEKIKASICTFLSVLSHLDIIVQNIPEKKLVLKQALTVALQWCLSHNFSVRLYALVALKKAWHLCKTLQFEECGAWTAVIECSLSQAESMHGAGNARKNWQRIQDHFFFSTFHPLKDYCLETIFYTLPRLSGVTGEEWIALDKFANFTDIPSNAGSQWYLSGTALGELSPGDWSQQDQGSTLGEADSQSEWADVQKKIIPWGQSALESDLELEFQDRAAKLGKSISRLIVVASLIDKPTNLGGLCRTCEVFGAAVLVVGSLQCVSDRQFQHLSVSAEQWLPLVEVRPSQLMNYLQQKKAEGYTVIGVEQTAQSSDLAQYRFPEKSLLLLGNEREGIPANLIQQLDVCVEIPQQGIIRSLNVHVSGALLIWEYTRQQLLGCAEPPS", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more TARBP1_dom, SpoU_MeTrfase, Trm3/TARBP1_C that are essential for its biological function; 2. The protein should belong to Trm3/TARBP1, Prob_MeTrfase_TARBP1 that shares evolutionary origin and functional similarity; 3. The protein should be classified within ARM-type_fold, tRNA_m1G_MTases_N, Alpha/beta_knot_MTases sharing conserved structural features. The designed protein sequence is ", "reference": "MERVLADALLTQSREPGELLGALCGGEASAERAETLRLVLQRLEERGAGAGALAKAAHEVARDHLVPLLHASQGGGPARPRVLRAASAALRSCARLAGPELAVTLAEEALRELPSAPAVELLAAVAPCLRAPEDAPLLRRLGRASVELALAGDAPPAVGARLLPALAQSAEPALRAAWDALSSAGPGAEGSTGPELLVLSALAEKLLTNHERHGDLDARLCGRFWRTVQAGLGRAQDGLTRKRARYLLQRAVQVSAELAVDCSCSPQDTKGPSLFWWSEKRKDELLKFWENYILIMEILEGNQIHVIKPALPKLNRLFECAVSEENGCWLFHPSWHTCIYKRMFESENKILAKEGVIHFLELYDVKSLPYSPELSEFITGPLMDALSESCLYSRSPGQPLGSDSPLGLKLQKFLVTYTSLLPEETKSCFLLKLIQRMADRHWCAVPVLFLSRALASIPSCKALGGEGLLALRDVLQRTMITHQVLLRGAAQCYLLQTAMRLVDVEKVSLSDISAFLLSLRQEESLGRGTVLWTELCDWLRVNERYFKQSSLGGSDGQEASLNAYVKNLVQEFVKSPGWEKESSFMPDWLDARLTALMVLLAVDVEGLKTKFREKQRTQNVLRIFLDPLLDALGKLGTNAYMPLLRTDRCLQLLVRLLHSCVPRRPGAQDDEVSTALQGSIMSASESVSQFVLRRLTMNELQDVADLDRCQLYLTVLSELMSLQVKLGWKAGNPISRVLSPLKNACVRHLQEAEDRQEPTLSHQVQRVVSMAALAALCEAVDQYPVLQPDSPNAEPVDRFLSALPLNHVLQKPRSEEQSIGVCPLENGSVFEESLSSKGWGKVVAQYLHDQWVCLSFLLRKHHHLIPSTESDVLEGFLPTAETPVQALQAALDVLTVLPAGRILPVFRCMEVLVPKLLTSEETLCIESFDVAWKIISSLSNTQLTFWPNLKAFVHFVFDHEILTIAAKLKGQVYFKIKEIMCKMIEMSSIKSGVFNILIRHCCQSWLVAASGVSQGSFSSAKDYSELVLEACVFGTVFRRDQRLIQDVQTFIENLGQGCAANVIIENAKREDYYVRICAIKFLCLLDGSDVSHKLFLEALAIKLLDKDESASRSRTRYHENSLQHRVKNRVWQTLLVLFPAFDQNFLHGIIDKVFHAGFTNNQASIKYFIEWLIILILHKFPEFLPKFWACFSYGEEKIKASICTFLSVLSHLDIIVQNIPEKKLVLKQALTVALQWCLSHNFSVRLYALVALKKAWHLCKTLQFEECGAWTAVIECSLSQAESMHGAGNARKNWQRIQDHFFFSTFHPLKDYCLETIFYTLPRLSGVTGEEWIALDKFANFTDIPSNAGSQWYLSGTALGELSPGDWSQQDQGSTLGEADSQSEWADVQKKIIPWGQSALESDLELEFQDRAAKLGKSISRLIVVASLIDKPTNLGGLCRTCEVFGAAVLVVGSLQCVSDRQFQHLSVSAEQWLPLVEVRPSQLMNYLQQKKAEGYTVIGVEQTAQSSDLAQYRFPEKSLLLLGNEREGIPANLIQQLDVCVEIPQQGIIRSLNVHVSGALLIWEYTRQQLLGCAEPPS" }, { "InterPro": [ { "InterPro-ID": "IPR001789", "InterPro-Name": "Sig_transdc_resp-reg_receiver", "InterPro-Type": "DOMAIN", "Beg": 853, "End": 996 }, { "InterPro-ID": "IPR001789", "InterPro-Name": "Sig_transdc_resp-reg_receiver", "InterPro-Type": "DOMAIN", "Beg": 855, "End": 922 }, { "InterPro-ID": "IPR001789", "InterPro-Name": "Sig_transdc_resp-reg_receiver", "InterPro-Type": "DOMAIN", "Beg": 854, "End": 1000 }, { "InterPro-ID": "IPR011006", "InterPro-Name": "CheY-like_superfamily", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 851, "End": 999 } ], "response#1": "MLLWKAAATKLRGVKGMRGFRDKIKGTKTKLLRRDSKDSTEEASAVRPSKTAKGGPGTGTETGSGGSGEGSWGRKSKRHSLIGRDPSRSDQSLVAPSDRTFDTTTDLDTTSISGNGNANPTASANGDIVIEGGTAPKRRSAGKEFDNLEDGTGLQPQLLNTTAKPLELSPAPPLTDTTGSIESPSTAAPDKGSFNCELPVVLSQKDSLKLNKNGILVGVESRPPSQIPLAENENLQPQPQPQPPQSNAAATAASAASVSALIQPSEGTPSKASTTGQSSTLSLPSDKTVILESTTPAVPSTSTPSTNIAATTTTAAITTTSVPAPTTTISRTPSRKLSDRSSDLSINTTNLPPPFTRPYRLSQFPTDSSGLRADTDSSALSQLQRSSSRASLGIHEPIAPETVEPPFRDKRESSFSHGPETLVYTGPLLHNPPEPASVVPVAAEVAQTLHTVSETGTFQPTELARNESVVSRNESVKSRILSSSGSRRKHPLSFSRRQSLIHPSDTGLLRYLLEQESASPTTYGREGGSNIQSVAGLMPHSENQLRTRKVWVKRPGGSPTQVIVTEDDFVDTVRDLCLRKYTNALGRHYDSPDLMIRISPPLKPQSARARQMGNMQTHTDRLLNPDEVLCQLLDDYYPNGQTSEDALIVEVPQQQRSRTPRPSPGPHSMSYAYGQTVHDLQLPGEDYFTPVGTIVPSIPHSQSGTVRSTHNLPANPSSLSNYIANSPPPSSPGHRSLKRPGPVRMTTGSPVGSTTSSAPGGGGGGVMLIPRAGGVVPDRIRATNVEAPTSPSVPPQMVALPSSPGIIKPIPQKPASPGVLPAVTSPPAITRPPPKSKEITASIGTLDGQVPSINVLIVEDNIINLRLLEAFMKRLKVRWATAMNGREAVTKWRTGGFQLVLMDIQLPIMNGLDATKEIRRLERLNGIGSFSSSPSGPEDELSSADKLDKSLVFKGSVIIVALTASSLRSDRDEALAVGCNDFLTKPVNFTFLERKVMEWGCMQALIDFEGWRKWKDLASKPGASGGKTSKGGRGKASASTSAAAKKGKESSISVLDNASSSSSTPQPTQSVPIAGQS", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Sig_transdc_resp-reg_receiver, Sig_transdc_resp-reg_receiver, Sig_transdc_resp-reg_receiver that are essential for its biological function; 2. The protein should be classified within CheY-like_superfamily sharing conserved structural features. The designed protein sequence is ", "reference": "MLLWKAAATKLRGVKGMRGFRDKIKGTKTKLLRRDSKDSTEEASAVRPSKTAKGGPGTGTETGSGGSGEGSWGRKSKRHSLIGRDPSRSDQSLVAPSDRTFDTTTDLDTTSISGNGNANPTASANGDIVIEGGTAPKRRSAGKEFDNLEDGTGLQPQLLNTTAKPLELSPAPPLTDTTGSIESPSTAAPDKGSFNCELPVVLSQKDSLKLNKNGILVGVESRPPSQIPLAENENLQPQPQPQPPQSNAAATAASAASVSALIQPSEGTPSKASTTGQSSTLSLPSDKTVILESTTPAVPSTSTPSTNIAATTTTAAITTTSVPAPTTTISRTPSRKLSDRSSDLSINTTNLPPPFTRPYRLSQFPTDSSGLRADTDSSALSQLQRSSSRASLGIHEPIAPETVEPPFRDKRESSFSHGPETLVYTGPLLHNPPEPASVVPVAAEVAQTLHTVSETGTFQPTELARNESVVSRNESVKSRILSSSGSRRKHPLSFSRRQSLIHPSDTGLLRYLLEQESASPTTYGREGGSNIQSVAGLMPHSENQLRTRKVWVKRPGGSPTQVIVTEDDFVDTVRDLCLRKYTNALGRHYDSPDLMIRISPPLKPQSARARQMGNMQTHTDRLLNPDEVLCQLLDDYYPNGQTSEDALIVEVPQQQRSRTPRPSPGPHSMSYAYGQTVHDLQLPGEDYFTPVGTIVPSIPHSQSGTVRSTHNLPANPSSLSNYIANSPPPSSPGHRSLKRPGPVRMTTGSPVGSTTSSAPGGGGGGVMLIPRAGGVVPDRIRATNVEAPTSPSVPPQMVALPSSPGIIKPIPQKPASPGVLPAVTSPPAITRPPPKSKEITASIGTLDGQVPSINVLIVEDNIINLRLLEAFMKRLKVRWATAMNGREAVTKWRTGGFQLVLMDIQLPIMNGLDATKEIRRLERLNGIGSFSSSPSGPEDELSSADKLDKSLVFKGSVIIVALTASSLRSDRDEALAVGCNDFLTKPVNFTFLERKVMEWGCMQALIDFEGWRKWKDLASKPGASGGKTSKGGRGKASASTSAAAKKGKESSISVLDNASSSSSTPQPTQSVPIAGQS" }, { "InterPro": [ { "InterPro-ID": "IPR007219", "InterPro-Name": "Transcription_factor_dom_fun", "InterPro-Type": "DOMAIN", "Beg": 333, "End": 570 }, { "InterPro-ID": "IPR001138", "InterPro-Name": "Zn2Cys6_DnaBD", "InterPro-Type": "DOMAIN", "Beg": 178, "End": 214 }, { "InterPro-ID": "IPR036864", "InterPro-Name": "Zn2-C6_fun-type_DNA-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 177, "End": 259 }, { "InterPro-ID": "IPR001138", "InterPro-Name": "Zn2Cys6_DnaBD", "InterPro-Type": "DOMAIN", "Beg": 178, "End": 206 }, { "InterPro-ID": "IPR001138", "InterPro-Name": "Zn2Cys6_DnaBD", "InterPro-Type": "DOMAIN", "Beg": 174, "End": 209 }, { "InterPro-ID": "IPR001138", "InterPro-Name": "Zn2Cys6_DnaBD", "InterPro-Type": "DOMAIN", "Beg": 178, "End": 208 }, { "InterPro-ID": "IPR007219", "InterPro-Name": "Transcription_factor_dom_fun", "InterPro-Type": "DOMAIN", "Beg": 434, "End": 516 }, { "InterPro-ID": "IPR050815", "InterPro-Name": "TF_fung", "InterPro-Type": "FAMILY", "Beg": 116, "End": 863 }, { "InterPro-ID": "IPR001138", "InterPro-Name": "Zn2Cys6_DnaBD", "InterPro-Type": "DOMAIN", "Beg": 173, "End": 217 }, { "InterPro-ID": "IPR036864", "InterPro-Name": "Zn2-C6_fun-type_DNA-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 169, "End": 214 } ], "response#1": "MSGRAVSNSQHAQQSFGSGPQLYRDVAELHAVPSPSHGALMDPSHFDDFAFAYQGLPDQPSLVSLADHAHAHASQSPTAFPQHQAMSGLAHNGLPFGALPAGNRSQSMDGSDAPPDRTSPASNALEDSTTDEFGLASRSRADATDLGGKPKEDKADATPAWSELKTKAGKERKRLPLACIACRRKKIRCSGEKPACKHCLRSRIPCVYKVTTRKAAPRTDYMAMLDKRLKRMEERIIKVIPKSDQEVASSVTRAVVKPAIPGTVPSNKPTKKRGAEEAFGPDLEAWAKAPSKPKIDGDDRPSSLQVQEAEENKLQHEGTEALPSKEIQEHLAEVFFDNIYGQSYHLLHKPSYMRKLKNGTLPPVLVLTVCAVAARFTSSPLVNSSGPEFLRGEEWASHARDICTRRYEWPNLTILTCLLILGLHEFGTCQGGRSWALGGQAIRMAFALQLHKDLEYDPSGRTGPKKQLSFIDREIRRRIMWACFLMDRFNSSGTDRPMFIREDTIQIPLPVKEKYFQFDMPAPTEMLDGQVPHPASPNDGQLADARENMGVAAFLIRAIALWGRIITYLSQGGKDLDPNPMWEDESQYVKHLNDVVNLEASLPSSLKYSAENLDVHKTENTASQFLFMHICLQHNILFVSRAAMSARKQQGVHDDFFSEASKRTFSAANQISELLREAEQSRCFVSAPFAGYCAFSSTTVHILGVISGNPNMKPTAEANLTTNVKYLHKMKKYWGMFHWMVENVRTQYRNALDAMRAGANLQDRAAQSSFLQYGDWFNRYPHGLSDAEFMDPATHKRKDSGADGVLEAKPELQSVEEYFSTLPTPQSVEHKDTIRAVGTKRKQSAKKQAGLPTQSGQHLESMQGTDADSVSGAQERRFSGGLGLPSNSYNPLAVSNAQNPAFSTAMSPMSPANMTAFSHHAHTPTFFPPELLAMNFGQGANGNIDPLDRQLVFGGYSLDASTGLGGGQDIMSGLDWDAVASGAHPDGGLQGRRSTAKAGMNGQAAGMADGAGLSGPEASSAWFMPFNMEPPEMGQDPGFNMGGIDPFTGVFGGGGSGLATPNALGGLQQQGP", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Transcription_factor_dom_fun, Zn2Cys6_DnaBD, Zn2Cys6_DnaBD, Zn2Cys6_DnaBD, Zn2Cys6_DnaBD, Transcription_factor_dom_fun, Zn2Cys6_DnaBD that are essential for its biological function; 2. The protein should belong to TF_fung that shares evolutionary origin and functional similarity; 3. The protein should be classified within Zn2-C6_fun-type_DNA-bd_sf, Zn2-C6_fun-type_DNA-bd_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MSGRAVSNSQHAQQSFGSGPQLYRDVAELHAVPSPSHGALMDPSHFDDFAFAYQGLPDQPSLVSLADHAHAHASQSPTAFPQHQAMSGLAHNGLPFGALPAGNRSQSMDGSDAPPDRTSPASNALEDSTTDEFGLASRSRADATDLGGKPKEDKADATPAWSELKTKAGKERKRLPLACIACRRKKIRCSGEKPACKHCLRSRIPCVYKVTTRKAAPRTDYMAMLDKRLKRMEERIIKVIPKSDQEVASSVTRAVVKPAIPGTVPSNKPTKKRGAEEAFGPDLEAWAKAPSKPKIDGDDRPSSLQVQEAEENKLQHEGTEALPSKEIQEHLAEVFFDNIYGQSYHLLHKPSYMRKLKNGTLPPVLVLTVCAVAARFTSSPLVNSSGPEFLRGEEWASHARDICTRRYEWPNLTILTCLLILGLHEFGTCQGGRSWALGGQAIRMAFALQLHKDLEYDPSGRTGPKKQLSFIDREIRRRIMWACFLMDRFNSSGTDRPMFIREDTIQIPLPVKEKYFQFDMPAPTEMLDGQVPHPASPNDGQLADARENMGVAAFLIRAIALWGRIITYLSQGGKDLDPNPMWEDESQYVKHLNDVVNLEASLPSSLKYSAENLDVHKTENTASQFLFMHICLQHNILFVSRAAMSARKQQGVHDDFFSEASKRTFSAANQISELLREAEQSRCFVSAPFAGYCAFSSTTVHILGVISGNPNMKPTAEANLTTNVKYLHKMKKYWGMFHWMVENVRTQYRNALDAMRAGANLQDRAAQSSFLQYGDWFNRYPHGLSDAEFMDPATHKRKDSGADGVLEAKPELQSVEEYFSTLPTPQSVEHKDTIRAVGTKRKQSAKKQAGLPTQSGQHLESMQGTDADSVSGAQERRFSGGLGLPSNSYNPLAVSNAQNPAFSTAMSPMSPANMTAFSHHAHTPTFFPPELLAMNFGQGANGNIDPLDRQLVFGGYSLDASTGLGGGQDIMSGLDWDAVASGAHPDGGLQGRRSTAKAGMNGQAAGMADGAGLSGPEASSAWFMPFNMEPPEMGQDPGFNMGGIDPFTGVFGGGGSGLATPNALGGLQQQGP" }, { "InterPro": [ { "InterPro-ID": "IPR051793", "InterPro-Name": "NADH:flavin_oxidoreductase", "InterPro-Type": "FAMILY", "Beg": 8, "End": 509 }, { "InterPro-ID": "IPR023753", "InterPro-Name": "FAD/NAD-binding_dom", "InterPro-Type": "DOMAIN", "Beg": 382, "End": 624 }, { "InterPro-ID": "IPR001155", "InterPro-Name": "OxRdtase_FMN_N", "InterPro-Type": "DOMAIN", "Beg": 9, "End": 341 }, { "InterPro-ID": "IPR013785", "InterPro-Name": "Aldolase_TIM", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 3, "End": 375 }, { "InterPro-ID": "IPR036188", "InterPro-Name": "FAD/NAD-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 358, "End": 673 }, { "InterPro-ID": "IPR036188", "InterPro-Name": "FAD/NAD-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 477, "End": 604 } ], "response#1": "MTTASSDPLLQPFTLKHLVLKNRVMSTSHASRLTRDEFPQEVYQRYHEEKAKGGLALTMFGGSSNVSLDSPNTFQQINLSADAVVPHLRRFSDRIHTHGAALMCQITHLGRRGDAYTEPWLPMIAPSPVRETLHRAMPQAIHDADIKRVIRDFGLAAKRCRDGGLDGIETHAGGHLIGQFMDPTVNLRTDKYGGSTANRVRFAIEVHEEIRKQVGDDFVVGFRFALEDGCSFEEGLEMSRILQGTGLFDFFNVTFGRMDTKMALAVNSMPGMFVPSAPWLPKAAAFKRAVDLPVFHAAKIADLATARYAIREGLLDMVGMTRAHIAEPHLVKLVEAGKEDEARPCVGASFCRNFRATCIHNPATSRETYLTHDIPKAAQTKRVLIVGAGPAGLEAARICATRGHDVTVLEANSTAGGQLLLAATGSWRRDLIGIVDWRVSALERLSVDVRYNHYAELSDVLDHGADVVIIATGGLPNLDALPGAEHCKSVFDALTETPPREGSVIVYDGTGRHNAYLCAERYVDAGLDVSLALIDSMPAQETGGRGDDQVWMRNIARWDVPVRTNIELIEVTASSNGKRRAVFQHHLTNERVELEADHVVVERGMLAVEDLFEAARMYSANDGYTDLEAFATGKPQPGHEAEEGQFHLYRIGDASASRDIHTAIYDAYRLCLAL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more FAD/NAD-binding_dom, OxRdtase_FMN_N that are essential for its biological function; 2. The protein should belong to NADH:flavin_oxidoreductase that shares evolutionary origin and functional similarity; 3. The protein should be classified within Aldolase_TIM, FAD/NAD-bd_sf, FAD/NAD-bd_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MTTASSDPLLQPFTLKHLVLKNRVMSTSHASRLTRDEFPQEVYQRYHEEKAKGGLALTMFGGSSNVSLDSPNTFQQINLSADAVVPHLRRFSDRIHTHGAALMCQITHLGRRGDAYTEPWLPMIAPSPVRETLHRAMPQAIHDADIKRVIRDFGLAAKRCRDGGLDGIETHAGGHLIGQFMDPTVNLRTDKYGGSTANRVRFAIEVHEEIRKQVGDDFVVGFRFALEDGCSFEEGLEMSRILQGTGLFDFFNVTFGRMDTKMALAVNSMPGMFVPSAPWLPKAAAFKRAVDLPVFHAAKIADLATARYAIREGLLDMVGMTRAHIAEPHLVKLVEAGKEDEARPCVGASFCRNFRATCIHNPATSRETYLTHDIPKAAQTKRVLIVGAGPAGLEAARICATRGHDVTVLEANSTAGGQLLLAATGSWRRDLIGIVDWRVSALERLSVDVRYNHYAELSDVLDHGADVVIIATGGLPNLDALPGAEHCKSVFDALTETPPREGSVIVYDGTGRHNAYLCAERYVDAGLDVSLALIDSMPAQETGGRGDDQVWMRNIARWDVPVRTNIELIEVTASSNGKRRAVFQHHLTNERVELEADHVVVERGMLAVEDLFEAARMYSANDGYTDLEAFATGKPQPGHEAEEGQFHLYRIGDASASRDIHTAIYDAYRLCLAL" }, { "InterPro": [ { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 52, "End": 144 }, { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 52, "End": 146 } ], "response#1": "MQFSVAAVLALATAVAALPPASGTGAGQQVGHSKNDFPLPKELTTKQAADKCGDQAQLTCCNKTVKTGDFTQVEEGLLAGLLSNLLGAGQGSQGLGLLDECTNIPVIPIISIASPQEKCKQPISCCQNTKSSADGDLVGIGLPCIALGSLL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Hydrophobin, Hydrophobin that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MQFSVAAVLALATAVAALPPASGTGAGQQVGHSKNDFPLPKELTTKQAADKCGDQAQLTCCNKTVKTGDFTQVEEGLLAGLLSNLLGAGQGSQGLGLLDECTNIPVIPIISIASPQEKCKQPISCCQNTKSSADGDLVGIGLPCIALGSLL" }, { "InterPro": [ { "InterPro-ID": "IPR014001", "InterPro-Name": "Helicase_ATP-bd", "InterPro-Type": "DOMAIN", "Beg": 29, "End": 247 }, { "InterPro-ID": "IPR001650", "InterPro-Name": "Helicase_C-like", "InterPro-Type": "DOMAIN", "Beg": 290, "End": 376 }, { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 41, "End": 381 }, { "InterPro-ID": "IPR017170", "InterPro-Name": "Lhr-like_ATP-dep_RNA_helic_prd", "InterPro-Type": "FAMILY", "Beg": 4, "End": 872 }, { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 12, "End": 233 }, { "InterPro-ID": "IPR001650", "InterPro-Name": "Helicase_C-like", "InterPro-Type": "DOMAIN", "Beg": 268, "End": 377 }, { "InterPro-ID": "IPR045628", "InterPro-Name": "Lhr_WH_dom", "InterPro-Type": "DOMAIN", "Beg": 408, "End": 565 }, { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 254, "End": 398 }, { "InterPro-ID": "IPR014001", "InterPro-Name": "Helicase_ATP-bd", "InterPro-Type": "DOMAIN", "Beg": 41, "End": 232 }, { "InterPro-ID": "IPR001650", "InterPro-Name": "Helicase_C-like", "InterPro-Type": "DOMAIN", "Beg": 249, "End": 421 }, { "InterPro-ID": "IPR052511", "InterPro-Name": "ATP-dep_Helicase", "InterPro-Type": "FAMILY", "Beg": 15, "End": 863 }, { "InterPro-ID": "IPR011545", "InterPro-Name": "DEAD/DEAH_box_helicase_dom", "InterPro-Type": "DOMAIN", "Beg": 34, "End": 218 }, { "InterPro-ID": "IPR013701", "InterPro-Name": "DEAD/DEAH_assoc", "InterPro-Type": "DOMAIN", "Beg": 638, "End": 827 } ], "response#1": "MDINTLLNTPDEDVLSLFTPQVARWFKEKYKVFTPPQKGAIPLIKKGKNVLVSSPTGSGKTLAAFLGILDTLIDLGYKNELNKQIYAIYISPLRALNNDMRRNLIEPLTELRNLYPDLPEISIGVRTSDTSSYEKQKMLKKPPHILITTPESFGISLVSPKFREKLSDVKWVIVDEIHELANSKRGAYLAGLLELYKSFIAKNNFVRIGLSATISPLEEVAKFLVGGNGDYEIIDARFVKPTDIQVVSPVKDLVHATEEEVNIGIYSYLVDEIKKHKTTLIFTNTRHAAERVAYKLRKMFEDQNIFDSDLVAAHHSSLSRDVRLEVEEKLKRGELKVVVSSTSLELGIDIGYIDLVTLLSSPKSVSRLLQRVGRAGHHIREVSKGRVVVVDRDDLVECTVLAKLAIDRKIDNIHVPENPLDVLTQLIVAASLITPIEKDKLYEIIKNVYNFRSLSYDEYNNVAEYLAGNYGLDSNKVYAKIRIKDGMISPKRGTRMIFFLNSGTIPDEAMIPVKMENGGYVGNLEEEFVEILAPGDIFVLAGKTYEFIRSEGNSVIVKKSEGQRPTVPSWFSEMLPLAFDSAIEIGKFRGKIAEAIMNEVPKDEVISSIMSEYNLSRFAALSIYNYVKEELLFTGGIVPTDKLLLIEVYDDDDQNRNFIFHGLYGRRTVDALSRAIAYIISKDLNMDVRIAITDNGFAITVPGKQEYEISKVFDKLEPDKMYEILSDVILRTEMIKRRFRHCAERSFMLLKRYKGRETSIDRRQINSEVLLGVVRQIEHFPVLKETVREILEDYMDIKRAIEIVEKIRNGDIKVATIGPNQVPSPFAHNILVKQYTDVVLAEDKRELLKELHNKVIEFLRNKGIDIDLEYTEAGIK", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Helicase_ATP-bd, Helicase_C-like, Helicase_C-like, Lhr_WH_dom, Helicase_ATP-bd, Helicase_C-like, DEAD/DEAH_box_helicase_dom, DEAD/DEAH_assoc that are essential for its biological function; 2. The protein should belong to Lhr-like_ATP-dep_RNA_helic_prd, ATP-dep_Helicase that shares evolutionary origin and functional similarity; 3. The protein should be classified within P-loop_NTPase, P-loop_NTPase, P-loop_NTPase sharing conserved structural features. The designed protein sequence is ", "reference": "MDINTLLNTPDEDVLSLFTPQVARWFKEKYKVFTPPQKGAIPLIKKGKNVLVSSPTGSGKTLAAFLGILDTLIDLGYKNELNKQIYAIYISPLRALNNDMRRNLIEPLTELRNLYPDLPEISIGVRTSDTSSYEKQKMLKKPPHILITTPESFGISLVSPKFREKLSDVKWVIVDEIHELANSKRGAYLAGLLELYKSFIAKNNFVRIGLSATISPLEEVAKFLVGGNGDYEIIDARFVKPTDIQVVSPVKDLVHATEEEVNIGIYSYLVDEIKKHKTTLIFTNTRHAAERVAYKLRKMFEDQNIFDSDLVAAHHSSLSRDVRLEVEEKLKRGELKVVVSSTSLELGIDIGYIDLVTLLSSPKSVSRLLQRVGRAGHHIREVSKGRVVVVDRDDLVECTVLAKLAIDRKIDNIHVPENPLDVLTQLIVAASLITPIEKDKLYEIIKNVYNFRSLSYDEYNNVAEYLAGNYGLDSNKVYAKIRIKDGMISPKRGTRMIFFLNSGTIPDEAMIPVKMENGGYVGNLEEEFVEILAPGDIFVLAGKTYEFIRSEGNSVIVKKSEGQRPTVPSWFSEMLPLAFDSAIEIGKFRGKIAEAIMNEVPKDEVISSIMSEYNLSRFAALSIYNYVKEELLFTGGIVPTDKLLLIEVYDDDDQNRNFIFHGLYGRRTVDALSRAIAYIISKDLNMDVRIAITDNGFAITVPGKQEYEISKVFDKLEPDKMYEILSDVILRTEMIKRRFRHCAERSFMLLKRYKGRETSIDRRQINSEVLLGVVRQIEHFPVLKETVREILEDYMDIKRAIEIVEKIRNGDIKVATIGPNQVPSPFAHNILVKQYTDVVLAEDKRELLKELHNKVIEFLRNKGIDIDLEYTEAGIK" }, { "InterPro": [ { "InterPro-ID": "IPR025402", "InterPro-Name": "DMP19_C", "InterPro-Type": "DOMAIN", "Beg": 41, "End": 155 } ], "response#1": "MTALTLPEDIRQQEPSALLYTLVSAYLEHTAQTGDESLSCLSDDQHTLTAFCYLDSQVEEGGFVQLIASGYGEYIFRNPLADSLRRWKIKAVPKVLDKAKALYEQHGKTIETLADGGADIPSLRKQFPEFEEWDGAYYEAAEQDLPLLAEHIQSNWETFAHIGQA", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more DMP19_C that are essential for its biological function. The designed protein sequence is ", "reference": "MTALTLPEDIRQQEPSALLYTLVSAYLEHTAQTGDESLSCLSDDQHTLTAFCYLDSQVEEGGFVQLIASGYGEYIFRNPLADSLRRWKIKAVPKVLDKAKALYEQHGKTIETLADGGADIPSLRKQFPEFEEWDGAYYEAAEQDLPLLAEHIQSNWETFAHIGQA" }, { "InterPro": [ { "InterPro-ID": "IPR023170", "InterPro-Name": "HhH_base_excis_C", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 143, "End": 214 }, { "InterPro-ID": "IPR003265", "InterPro-Name": "HhH-GPD_domain", "InterPro-Type": "DOMAIN", "Beg": 35, "End": 194 }, { "InterPro-ID": "IPR003651", "InterPro-Name": "Endonuclease3_FeS-loop_motif", "InterPro-Type": "CONSERVED_SITE", "Beg": 197, "End": 217 }, { "InterPro-ID": "IPR003265", "InterPro-Name": "HhH-GPD_domain", "InterPro-Type": "DOMAIN", "Beg": 40, "End": 176 }, { "InterPro-ID": "IPR011257", "InterPro-Name": "DNA_glycosylase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 21, "End": 220 }, { "InterPro-ID": "IPR003265", "InterPro-Name": "HhH-GPD_domain", "InterPro-Type": "DOMAIN", "Beg": 43, "End": 196 } ], "response#1": "MDIANQLYMKLREEYKIDQKEFISSYICGKTRNVFATILATILSQNSTDKSALIAFSKLNETVGEITPDRIKHADINTIIDAIRVAGLGNSKARYIKNVAEVINDLDLNIEIDCQKLRDFLTAIEGIGDKTADVVLLTCFRCREFPIDTHIRRVISRLGFLGSSPKYKDISEYFKTRFSSEDLLNLHHLLIAHGRKTCKSRKPICDKCVIRDYCKYYLDNIKN", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more HhH-GPD_domain, HhH-GPD_domain, HhH-GPD_domain that are essential for its biological function; 2. The protein should be classified within HhH_base_excis_C, DNA_glycosylase sharing conserved structural features; 3. The protein should contain Endonuclease3_FeS-loop_motif that is preserved across related proteins. The designed protein sequence is ", "reference": "MDIANQLYMKLREEYKIDQKEFISSYICGKTRNVFATILATILSQNSTDKSALIAFSKLNETVGEITPDRIKHADINTIIDAIRVAGLGNSKARYIKNVAEVINDLDLNIEIDCQKLRDFLTAIEGIGDKTADVVLLTCFRCREFPIDTHIRRVISRLGFLGSSPKYKDISEYFKTRFSSEDLLNLHHLLIAHGRKTCKSRKPICDKCVIRDYCKYYLDNIKN" }, { "InterPro": [ { "InterPro-ID": "IPR000757", "InterPro-Name": "GH16", "InterPro-Type": "DOMAIN", "Beg": 20, "End": 220 }, { "InterPro-ID": "IPR013320", "InterPro-Name": "ConA-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 19, "End": 235 }, { "InterPro-ID": "IPR017168", "InterPro-Name": "Glyco_hydro_16_CRH1_prd", "InterPro-Type": "FAMILY", "Beg": 1, "End": 342 }, { "InterPro-ID": "IPR050546", "InterPro-Name": "Glycosyl_Hydrlase_16", "InterPro-Type": "FAMILY", "Beg": 35, "End": 235 }, { "InterPro-ID": "IPR000757", "InterPro-Name": "GH16", "InterPro-Type": "DOMAIN", "Beg": 46, "End": 213 } ], "response#1": "MMLPLLAVSAFASLGAAQTYTSCNPTNSLKTWSLSTDFTQGSSDGWTAISGNVTYGSNGAEFTINKRYDAPTLETNFYIFFGEVEVVMRAANGTGIVSSIVMESDDLDEIDWECTGTDTTQIQTNYFGKGNTTTYDRAIWETVSSPQDEFHTYKVVWTAAAITWYIDGTAVRTLEYADAVDGKNYPQTPMVVKLGIWAGGDPSNSEGTIEWAGGETDYDEVPFTMYVKSVNIINYNPAASYNYTDKTGSYTSIVASNSTTGSGIHSSNSVSVFAPSSSTSTFTSSRALIATASTYPASVQTSSSGVVSLSSSSASSSSAAASSTSGSASAVFTGAAVTNLPSFFFTVFFALAIALAF", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more GH16, GH16 that are essential for its biological function; 2. The protein should belong to Glyco_hydro_16_CRH1_prd, Glycosyl_Hydrlase_16 that shares evolutionary origin and functional similarity; 3. The protein should be classified within ConA-like_dom_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MMLPLLAVSAFASLGAAQTYTSCNPTNSLKTWSLSTDFTQGSSDGWTAISGNVTYGSNGAEFTINKRYDAPTLETNFYIFFGEVEVVMRAANGTGIVSSIVMESDDLDEIDWECTGTDTTQIQTNYFGKGNTTTYDRAIWETVSSPQDEFHTYKVVWTAAAITWYIDGTAVRTLEYADAVDGKNYPQTPMVVKLGIWAGGDPSNSEGTIEWAGGETDYDEVPFTMYVKSVNIINYNPAASYNYTDKTGSYTSIVASNSTTGSGIHSSNSVSVFAPSSSTSTFTSSRALIATASTYPASVQTSSSGVVSLSSSSASSSSAAASSTSGSASAVFTGAAVTNLPSFFFTVFFALAIALAF" }, { "InterPro": [ { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 34, "End": 108 }, { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 34, "End": 111 } ], "response#1": "MVSFRAFTVAASLFATLAAATPLDTALPRAADQCNVSNQQCCNSVQQASSGPAALILGLLGVVLQDVNVLVGLDCSPITVIGGGNGGCNASPVCCENNSFGSLISIGCVPISI", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Hydrophobin, Hydrophobin that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MVSFRAFTVAASLFATLAAATPLDTALPRAADQCNVSNQQCCNSVQQASSGPAALILGLLGVVLQDVNVLVGLDCSPITVIGGGNGGCNASPVCCENNSFGSLISIGCVPISI" }, { "InterPro": [ { "InterPro-ID": "IPR000757", "InterPro-Name": "GH16", "InterPro-Type": "DOMAIN", "Beg": 55, "End": 223 }, { "InterPro-ID": "IPR000757", "InterPro-Name": "GH16", "InterPro-Type": "DOMAIN", "Beg": 26, "End": 237 }, { "InterPro-ID": "IPR050546", "InterPro-Name": "Glycosyl_Hydrlase_16", "InterPro-Type": "FAMILY", "Beg": 8, "End": 244 }, { "InterPro-ID": "IPR013320", "InterPro-Name": "ConA-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 22, "End": 246 } ], "response#1": "MSLLYLVALFVASICSVTAQTWTSCNPLTTTCPPDQALGINTTFTFNKTLDDTIWNVTNGVLSHTDEGTEFTITGENQSPTMQSNFYIFFGIVESHVKMAKGAGIISSIVLQSDDLDEIDWEWVGYNTSEVQSNYFGKGNNETFNRGGYHYVPNADTEFHNYTTYWTQEKLEWWIDGKLARTLTYEDSQGAGKYYPQTPCNIRYGIWPAGIKGNAQGTIEWAGGLVDYSKAPFTMVLQSVRVHDFHTGKEYNYTDHSGSWQSIDVIAGNSTIANAIQNPPKSLSEKWAELPTGAKAGVYIGAGCVGAALLAGFIFFFIAQRKKGRLEHALEDAKWANERTEMSTFQNDWKQSEWKHKGYQPVN", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more GH16, GH16 that are essential for its biological function; 2. The protein should belong to Glycosyl_Hydrlase_16 that shares evolutionary origin and functional similarity; 3. The protein should be classified within ConA-like_dom_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MSLLYLVALFVASICSVTAQTWTSCNPLTTTCPPDQALGINTTFTFNKTLDDTIWNVTNGVLSHTDEGTEFTITGENQSPTMQSNFYIFFGIVESHVKMAKGAGIISSIVLQSDDLDEIDWEWVGYNTSEVQSNYFGKGNNETFNRGGYHYVPNADTEFHNYTTYWTQEKLEWWIDGKLARTLTYEDSQGAGKYYPQTPCNIRYGIWPAGIKGNAQGTIEWAGGLVDYSKAPFTMVLQSVRVHDFHTGKEYNYTDHSGSWQSIDVIAGNSTIANAIQNPPKSLSEKWAELPTGAKAGVYIGAGCVGAALLAGFIFFFIAQRKKGRLEHALEDAKWANERTEMSTFQNDWKQSEWKHKGYQPVN" }, { "InterPro": [ { "InterPro-ID": "IPR015424", "InterPro-Name": "PyrdxlP-dep_Trfase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 9, "End": 470 }, { "InterPro-ID": "IPR039429", "InterPro-Name": "SHMT-like_dom", "InterPro-Type": "DOMAIN", "Beg": 18, "End": 417 }, { "InterPro-ID": "IPR019798", "InterPro-Name": "Ser_HO-MeTrfase_PLP_BS", "InterPro-Type": "BINDING_SITE", "Beg": 241, "End": 257 }, { "InterPro-ID": "IPR049943", "InterPro-Name": "Ser_HO-MeTrfase-like", "InterPro-Type": "FAMILY", "Beg": 7, "End": 470 }, { "InterPro-ID": "IPR001085", "InterPro-Name": "Ser_HO-MeTrfase", "InterPro-Type": "FAMILY", "Beg": 20, "End": 463 }, { "InterPro-ID": "IPR015421", "InterPro-Name": "PyrdxlP-dep_Trfase_major", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 47, "End": 321 }, { "InterPro-ID": "IPR015422", "InterPro-Name": "PyrdxlP-dep_Trfase_small", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 22, "End": 470 }, { "InterPro-ID": "IPR001085", "InterPro-Name": "Ser_HO-MeTrfase", "InterPro-Type": "FAMILY", "Beg": 3, "End": 471 }, { "InterPro-ID": "IPR001085", "InterPro-Name": "Ser_HO-MeTrfase", "InterPro-Type": "FAMILY", "Beg": 17, "End": 471 } ], "response#1": "MATYALSQAHREQMEKSLVDSDPEIAQIMEKEIQRQRESILLIASENVTSRAVFDALGSPMSNKYSEGYPGARYYGGNQHIDAIELTCQARALKAFNLDPEKWGVNVQCLSGSPANLEVYQALMRPHDRLMGLDLPHGGHLSHGYQTPSRKISAVSTYFETFPYRVNTETGIIDYDTLEANAELYRPKCLVAGTSAYCRLIDYGRMRKIADKVGAYLIVDMAHISGLVAAGVIPSPFEYADVVTTTTHKSLRGPRGAMIFFRKGVRSTDPKTGKEIMYDLEGPINFSVFPGHQGGPHNHTITALAVALKQAATPEFRQYQEQVLKNAKALEVEFKALGHKLVSDGTDSHMVLLDLRPKGLDGARVEAVLEQINIACNKNSIPGDKSALTPCGIRIGTPAMTSRGMSEEDFKRVARYIDQVINLCKSIQADLPKEANKLKDFKAKVASGSVPEILALRKEVAEWASTYPLPV", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more SHMT-like_dom that are essential for its biological function; 2. The protein should belong to Ser_HO-MeTrfase-like, Ser_HO-MeTrfase, Ser_HO-MeTrfase, Ser_HO-MeTrfase that shares evolutionary origin and functional similarity; 3. The protein should be classified within PyrdxlP-dep_Trfase, PyrdxlP-dep_Trfase_major, PyrdxlP-dep_Trfase_small sharing conserved structural features; 4. The protein should include a Ser_HO-MeTrfase_PLP_BS that enables ligand binding under diverse conditions. The designed protein sequence is ", "reference": "MATYALSQAHREQMEKSLVDSDPEIAQIMEKEIQRQRESILLIASENVTSRAVFDALGSPMSNKYSEGYPGARYYGGNQHIDAIELTCQARALKAFNLDPEKWGVNVQCLSGSPANLEVYQALMRPHDRLMGLDLPHGGHLSHGYQTPSRKISAVSTYFETFPYRVNTETGIIDYDTLEANAELYRPKCLVAGTSAYCRLIDYGRMRKIADKVGAYLIVDMAHISGLVAAGVIPSPFEYADVVTTTTHKSLRGPRGAMIFFRKGVRSTDPKTGKEIMYDLEGPINFSVFPGHQGGPHNHTITALAVALKQAATPEFRQYQEQVLKNAKALEVEFKALGHKLVSDGTDSHMVLLDLRPKGLDGARVEAVLEQINIACNKNSIPGDKSALTPCGIRIGTPAMTSRGMSEEDFKRVARYIDQVINLCKSIQADLPKEANKLKDFKAKVASGSVPEILALRKEVAEWASTYPLPV" }, { "InterPro": [ { "InterPro-ID": "IPR010636", "InterPro-Name": "Cerato-ulmin_hydrophobin", "InterPro-Type": "FAMILY", "Beg": 122, "End": 184 }, { "InterPro-ID": "IPR036686", "InterPro-Name": "Hydrophobin_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 114, "End": 184 }, { "InterPro-ID": "IPR036686", "InterPro-Name": "Hydrophobin_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 126, "End": 184 }, { "InterPro-ID": "IPR010636", "InterPro-Name": "Cerato-ulmin_hydrophobin", "InterPro-Type": "FAMILY", "Beg": 121, "End": 183 }, { "InterPro-ID": "IPR010636", "InterPro-Name": "Cerato-ulmin_hydrophobin", "InterPro-Type": "FAMILY", "Beg": 120, "End": 183 } ], "response#1": "MNFMLLSAALASMAVAGPIAGTYPITYPSSNTPATYPSGNAPIWSSPIHGGNNGGNGGNGGDNNGGNGGNGGSGGGNTGGNAGNGGGNNGGNNNGGNNGGNTGGEGGNGGNGGNGGAPVELCPANRVPQCCQLSVLGVADVTCASPSSGLTSVSAFEADCANDGTTAQCCLIPVLGLGLFCSNP", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Cerato-ulmin_hydrophobin, Cerato-ulmin_hydrophobin, Cerato-ulmin_hydrophobin that shares evolutionary origin and functional similarity; 2. The protein should be classified within Hydrophobin_sf, Hydrophobin_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MNFMLLSAALASMAVAGPIAGTYPITYPSSNTPATYPSGNAPIWSSPIHGGNNGGNGGNGGDNNGGNGGNGGSGGGNTGGNAGNGGGNNGGNNNGGNNGGNTGGEGGNGGNGGNGGAPVELCPANRVPQCCQLSVLGVADVTCASPSSGLTSVSAFEADCANDGTTAQCCLIPVLGLGLFCSNP" }, { "InterPro": [ { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 33, "End": 107 }, { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 33, "End": 110 } ], "response#1": "MQFTKMSAFATLALATLAAATPTRRNDSPSNQCNTGSLQCCNSLQSANSASLAGLLGLLGVVVGTITGQVGVTCSPITGVGVSGTSCSEQPVCCTNNAFNGVIALGCSPININL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Hydrophobin, Hydrophobin that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MQFTKMSAFATLALATLAAATPTRRNDSPSNQCNTGSLQCCNSLQSANSASLAGLLGLLGVVVGTITGQVGVTCSPITGVGVSGTSCSEQPVCCTNNAFNGVIALGCSPININL" }, { "InterPro": [ { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 29, "End": 106 }, { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 29, "End": 103 } ], "response#1": "MFARAASVFVLSLPILATANVLPRQDNQCNTGSLQCCSSVQSSSSSLVAILLGLLGVAAGGLTGQVGVTCSPITVIGVSGTSCSEQPVCCTGNTFNGVIATGCTPVNVNL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Hydrophobin, Hydrophobin that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MFARAASVFVLSLPILATANVLPRQDNQCNTGSLQCCSSVQSSSSSLVAILLGLLGVAAGGLTGQVGVTCSPITVIGVSGTSCSEQPVCCTGNTFNGVIATGCTPVNVNL" }, { "InterPro": [ { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 26, "End": 103 }, { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 26, "End": 100 } ], "response#1": "MQFKVLAALVIGATLAAATGSPSNQCNTGSLQCCNSTGSATDPAIAKLFALLGINVEDVTALVGVTCSPITVVGASGSSCSEQPVCCTNDSFNGIVALGCAPINLNL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Hydrophobin, Hydrophobin that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MQFKVLAALVIGATLAAATGSPSNQCNTGSLQCCNSTGSATDPAIAKLFALLGINVEDVTALVGVTCSPITVVGASGSSCSEQPVCCTNDSFNGIVALGCAPINLNL" }, { "InterPro": [ { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 35, "End": 108 }, { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 35, "End": 105 } ], "response#1": "MFSKATLFFTTVSRYRDTQAPIPTGQTNQPTTNQCNTGPVQCCDTTQSASDPINIPGMGLVHVSNANGLVAFGNCSPLVSGGSKCNNQAVCCNGTEFNGLVNVGCTNVSL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Hydrophobin, Hydrophobin that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MFSKATLFFTTVSRYRDTQAPIPTGQTNQPTTNQCNTGPVQCCDTTQSASDPINIPGMGLVHVSNANGLVAFGNCSPLVSGGSKCNNQAVCCNGTEFNGLVNVGCTNVSL" }, { "InterPro": [ { "InterPro-ID": "IPR052511", "InterPro-Name": "ATP-dep_Helicase", "InterPro-Type": "FAMILY", "Beg": 7, "End": 804 }, { "InterPro-ID": "IPR001650", "InterPro-Name": "Helicase_C-like", "InterPro-Type": "DOMAIN", "Beg": 266, "End": 347 }, { "InterPro-ID": "IPR001650", "InterPro-Name": "Helicase_C-like", "InterPro-Type": "DOMAIN", "Beg": 242, "End": 348 }, { "InterPro-ID": "IPR045628", "InterPro-Name": "Lhr_WH_dom", "InterPro-Type": "DOMAIN", "Beg": 375, "End": 544 }, { "InterPro-ID": "IPR017170", "InterPro-Name": "Lhr-like_ATP-dep_RNA_helic_prd", "InterPro-Type": "FAMILY", "Beg": 3, "End": 813 }, { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 5, "End": 204 }, { "InterPro-ID": "IPR026362", "InterPro-Name": "DEXH_lig_assoc", "InterPro-Type": "FAMILY", "Beg": 8, "End": 810 }, { "InterPro-ID": "IPR014001", "InterPro-Name": "Helicase_ATP-bd", "InterPro-Type": "DOMAIN", "Beg": 27, "End": 193 }, { "InterPro-ID": "IPR001650", "InterPro-Name": "Helicase_C-like", "InterPro-Type": "DOMAIN", "Beg": 240, "End": 402 }, { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 26, "End": 360 }, { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 235, "End": 392 }, { "InterPro-ID": "IPR013701", "InterPro-Name": "DEAD/DEAH_assoc", "InterPro-Type": "DOMAIN", "Beg": 596, "End": 781 }, { "InterPro-ID": "IPR014001", "InterPro-Name": "Helicase_ATP-bd", "InterPro-Type": "DOMAIN", "Beg": 15, "End": 230 }, { "InterPro-ID": "IPR011545", "InterPro-Name": "DEAD/DEAH_box_helicase_dom", "InterPro-Type": "DOMAIN", "Beg": 22, "End": 194 } ], "response#1": "MPAATDLANAWFAKRGWKPFAFQRRVWAAVERGESGLLHASTGAGKTYAVWLAALRAFKPRPQGRHLAPIQVLWVTPMRALAADTARALQAPLDELQLPWSVGVRSGDTNSAERARQARRLPSVLITTPESLTLLLTRAKAREDFATLQLVVVDEWHELLGNKRGVQLQLALARLRHWHPGLPTWGLSATLGNLQHARDVLLPQGGLLVQGRQDKALQVDTLLPKAIERFPWAGHMGLKMLDQVCHEIDASASSLVFTNTRAQAEIWYQALLEARPDWAGLIALHHASLARDTRDWVERSLKQGSLKAVICTSSLDLGVDFLPVERVLQIGSAKGIARLMQRAGRSGHAPGRRSRVTLVPTHSLELVEAAAARQALLAGHIEARFSPRLCMDVLVQHLVSMALGSGFRPEQLLAEVRSTWAFRQLRDSQWQWALDFVCHGGSSLTAYPDYQRVERQADGVYRVTSERLARRHRMGIGTIVSDANLQLKYWSKGGGGKTLGSVEEAFIARLRPGDTLVFAGRVLELVRVENMTAYVRRSTARKAAVARWNGGRMPLSSELADALVEQLDAAAHERFEGPEMRAVRPLLALQAQWSALPTTSTLLAETFKSRQGWHLFLYPFAGRMANLGLANLIAWRVSRAQPLSVSIAVNDYGFELLSPAQVDWASHLPQALGTADLLEDVLASLNAGEMALRRFREIAQIAGLVFGGYPAAQKSTRQIQASSGLFYEVFRKHDAGNLLLGQARDEVLSEELEIERLHRQLLKMSELQLDLQALRRPGPLAFALLVEGMRETLSTEKLADRIARMVAELEQAANAG", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Helicase_C-like, Helicase_C-like, Lhr_WH_dom, Helicase_ATP-bd, Helicase_C-like, DEAD/DEAH_assoc, Helicase_ATP-bd, DEAD/DEAH_box_helicase_dom that are essential for its biological function; 2. The protein should belong to ATP-dep_Helicase, Lhr-like_ATP-dep_RNA_helic_prd, DEXH_lig_assoc that shares evolutionary origin and functional similarity; 3. The protein should be classified within P-loop_NTPase, P-loop_NTPase, P-loop_NTPase sharing conserved structural features. The designed protein sequence is ", "reference": "MPAATDLANAWFAKRGWKPFAFQRRVWAAVERGESGLLHASTGAGKTYAVWLAALRAFKPRPQGRHLAPIQVLWVTPMRALAADTARALQAPLDELQLPWSVGVRSGDTNSAERARQARRLPSVLITTPESLTLLLTRAKAREDFATLQLVVVDEWHELLGNKRGVQLQLALARLRHWHPGLPTWGLSATLGNLQHARDVLLPQGGLLVQGRQDKALQVDTLLPKAIERFPWAGHMGLKMLDQVCHEIDASASSLVFTNTRAQAEIWYQALLEARPDWAGLIALHHASLARDTRDWVERSLKQGSLKAVICTSSLDLGVDFLPVERVLQIGSAKGIARLMQRAGRSGHAPGRRSRVTLVPTHSLELVEAAAARQALLAGHIEARFSPRLCMDVLVQHLVSMALGSGFRPEQLLAEVRSTWAFRQLRDSQWQWALDFVCHGGSSLTAYPDYQRVERQADGVYRVTSERLARRHRMGIGTIVSDANLQLKYWSKGGGGKTLGSVEEAFIARLRPGDTLVFAGRVLELVRVENMTAYVRRSTARKAAVARWNGGRMPLSSELADALVEQLDAAAHERFEGPEMRAVRPLLALQAQWSALPTTSTLLAETFKSRQGWHLFLYPFAGRMANLGLANLIAWRVSRAQPLSVSIAVNDYGFELLSPAQVDWASHLPQALGTADLLEDVLASLNAGEMALRRFREIAQIAGLVFGGYPAAQKSTRQIQASSGLFYEVFRKHDAGNLLLGQARDEVLSEELEIERLHRQLLKMSELQLDLQALRRPGPLAFALLVEGMRETLSTEKLADRIARMVAELEQAANAG" }, { "InterPro": [ { "InterPro-ID": "IPR024738", "InterPro-Name": "Hfi1/Tada1", "InterPro-Type": "FAMILY", "Beg": 8, "End": 253 }, { "InterPro-ID": "IPR024738", "InterPro-Name": "Hfi1/Tada1", "InterPro-Type": "FAMILY", "Beg": 8, "End": 199 } ], "response#1": "MLTDRVLATKEALVVALGDNWERYRANMKNWFRSRWTKEEFDAESRKILTPDKLHLHNQFLLALLNKIDAFAPLENPPAVQTSSSSGNRSKRRKRSSRTFAERLNFELSDVLDFVAEDNMQIIRPPTTIGIPSDQQQQQLQSQRYCAQELFLPDAGFIMGRFLIGAWEIGLVSVDDNVAEYVAMAVQVLLKDLLSAIIKKRKHYKTSGEGNFYYDVGAPLRDPSLRNTVTRQKVDDTPLELDKELNTANFMRRQNDDVTFLSACEEVQPTERTVITLKDCQLALRDRNLIGSHAVYSINMERLNMMMH", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Hfi1/Tada1, Hfi1/Tada1 that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MLTDRVLATKEALVVALGDNWERYRANMKNWFRSRWTKEEFDAESRKILTPDKLHLHNQFLLALLNKIDAFAPLENPPAVQTSSSSGNRSKRRKRSSRTFAERLNFELSDVLDFVAEDNMQIIRPPTTIGIPSDQQQQQLQSQRYCAQELFLPDAGFIMGRFLIGAWEIGLVSVDDNVAEYVAMAVQVLLKDLLSAIIKKRKHYKTSGEGNFYYDVGAPLRDPSLRNTVTRQKVDDTPLELDKELNTANFMRRQNDDVTFLSACEEVQPTERTVITLKDCQLALRDRNLIGSHAVYSINMERLNMMMH" }, { "InterPro": [ { "InterPro-ID": "IPR024738", "InterPro-Name": "Hfi1/Tada1", "InterPro-Type": "FAMILY", "Beg": 8, "End": 199 }, { "InterPro-ID": "IPR024738", "InterPro-Name": "Hfi1/Tada1", "InterPro-Type": "FAMILY", "Beg": 8, "End": 253 } ], "response#1": "MLTDRVLATKEALVVALGDNWERYRANMKNWFRSRWTKEEFDAESRKILTPDKLHLHNQFLLALLNKIDAFAPLENPPAVQTSSSSGNRSKRRKRSCRTFAERLNFELSDVLDFVAEDNMQIIRPPTTIGIPSDQQQQQLQSQRYCAQELFLPDAGFIMGRFLIGAWEIGLVSVDDNVAEYVAMAVQVLLKDLLSAIIKKRKHYKTSGEGNFYYDVGAPLRDPSLRNTVTRQKVDDTPLELDKELNTANFMRRQNDDVTFLSACEEVQPTERTVITLKDCQLALRDRNLIGSHAVYSINMERLNMMMH", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Hfi1/Tada1, Hfi1/Tada1 that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MLTDRVLATKEALVVALGDNWERYRANMKNWFRSRWTKEEFDAESRKILTPDKLHLHNQFLLALLNKIDAFAPLENPPAVQTSSSSGNRSKRRKRSCRTFAERLNFELSDVLDFVAEDNMQIIRPPTTIGIPSDQQQQQLQSQRYCAQELFLPDAGFIMGRFLIGAWEIGLVSVDDNVAEYVAMAVQVLLKDLLSAIIKKRKHYKTSGEGNFYYDVGAPLRDPSLRNTVTRQKVDDTPLELDKELNTANFMRRQNDDVTFLSACEEVQPTERTVITLKDCQLALRDRNLIGSHAVYSINMERLNMMMH" }, { "InterPro": [ { "InterPro-ID": "IPR000504", "InterPro-Name": "RRM_dom", "InterPro-Type": "DOMAIN", "Beg": 37, "End": 128 }, { "InterPro-ID": "IPR035979", "InterPro-Name": "RBD_domain_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 48, "End": 178 } ], "response#1": "MDFESKYCTSQVNGTITITTRKVLDENLKSLLDEGKGELFLSCIPRNHSCSPRWIVEVASELGEVYIMRYKIDFSGNSRGYAYLQYINVDLKESAMQYLPMRFRQLCMCLRVEPSTNNRELVLKNVESSLRPWQVYQEMLKIHPFTIVRVYEYQLDQFFYIFEYRNNDSAASAHQRVRNSIRKFGEHAHISWLTAENILSRASGSFCFQREVSQNRTRRVPPRQKGCFKF", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more RRM_dom that are essential for its biological function; 2. The protein should be classified within RBD_domain_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MDFESKYCTSQVNGTITITTRKVLDENLKSLLDEGKGELFLSCIPRNHSCSPRWIVEVASELGEVYIMRYKIDFSGNSRGYAYLQYINVDLKESAMQYLPMRFRQLCMCLRVEPSTNNRELVLKNVESSLRPWQVYQEMLKIHPFTIVRVYEYQLDQFFYIFEYRNNDSAASAHQRVRNSIRKFGEHAHISWLTAENILSRASGSFCFQREVSQNRTRRVPPRQKGCFKF" }, { "InterPro": [ { "InterPro-ID": "IPR016084", "InterPro-Name": "Haem_Oase-like_multi-hlx", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 107, "End": 302 }, { "InterPro-ID": "IPR016084", "InterPro-Name": "Haem_Oase-like_multi-hlx", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 130, "End": 288 } ], "response#1": "MIRKIIILMFTFFSNIHNEKIYHHKQRRKFLKGPLGYLNRNVIQKKHYNLYAKKFINYKEIQIQRINDYRKRSGVDKNNINYNLRDTYNYHETHLFVRNEVLPTLAKIENENLKEKEKNKEIFRNINDYNSNFTRQTFLQFLMDLYNIFLKIDDLFLENKTYFSILIYNGPMQLTNHLYDDIIYVSSVVENSDDVSPSEYCMEYISHLENLCEENKLSFLAHAYVFYKNFHLSKEHLLKSICKYLNIIKKLKSSTYVADVENFEFCLNKMSRKWSRWEKDNFLASLHNATNKMMILTKHFEKVKS", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should be classified within Haem_Oase-like_multi-hlx, Haem_Oase-like_multi-hlx sharing conserved structural features. The designed protein sequence is ", "reference": "MIRKIIILMFTFFSNIHNEKIYHHKQRRKFLKGPLGYLNRNVIQKKHYNLYAKKFINYKEIQIQRINDYRKRSGVDKNNINYNLRDTYNYHETHLFVRNEVLPTLAKIENENLKEKEKNKEIFRNINDYNSNFTRQTFLQFLMDLYNIFLKIDDLFLENKTYFSILIYNGPMQLTNHLYDDIIYVSSVVENSDDVSPSEYCMEYISHLENLCEENKLSFLAHAYVFYKNFHLSKEHLLKSICKYLNIIKKLKSSTYVADVENFEFCLNKMSRKWSRWEKDNFLASLHNATNKMMILTKHFEKVKS" }, { "InterPro": [ { "InterPro-ID": "IPR003689", "InterPro-Name": "ZIP", "InterPro-Type": "FAMILY", "Beg": 7, "End": 312 } ], "response#1": "MWLSTFLALLIFVECVIVVYIPAYIESKLSKIKKNRFFNMENFENIASGAILALAFLHMLPEVIILSNKKNMNLYYIFILVLVSVTFLNITDILYDHHFESTFDVNCTLACENSNNQIKNINDKEITTNYIDIKSNEVIDLELKAMDTNINNNNNNNNNNKTDPCKTNIFFEIFKSNSFFIVLSLFIHSFIEGLLMGSLKDKNAIIIVGLSMLAHKWAECLIVYKNVVNKIENPLLASIYAWSFILSLPLGVFIAIFSFPSNEFVEIIFSSIACGFFLYLSFNMTKEIKITKSNKHFISFSYFLGVGGMSTLMILFNSFESNNII", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to ZIP that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MWLSTFLALLIFVECVIVVYIPAYIESKLSKIKKNRFFNMENFENIASGAILALAFLHMLPEVIILSNKKNMNLYYIFILVLVSVTFLNITDILYDHHFESTFDVNCTLACENSNNQIKNINDKEITTNYIDIKSNEVIDLELKAMDTNINNNNNNNNNNKTDPCKTNIFFEIFKSNSFFIVLSLFIHSFIEGLLMGSLKDKNAIIIVGLSMLAHKWAECLIVYKNVVNKIENPLLASIYAWSFILSLPLGVFIAIFSFPSNEFVEIIFSSIACGFFLYLSFNMTKEIKITKSNKHFISFSYFLGVGGMSTLMILFNSFESNNII" }, { "InterPro": [ { "InterPro-ID": "IPR010489", "InterPro-Name": "Effector_NleG", "InterPro-Type": "FAMILY", "Beg": 94, "End": 205 }, { "InterPro-ID": "IPR038436", "InterPro-Name": "Effector_NleG_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 93, "End": 207 } ], "response#1": "MPVILNFSSERVLSESELEALRHVGRVSQSEQLVVRGRTMRLHHISFMDSFSVEPVSGGLLDRLSARGHRLLAENLEIQLNRGHTFLQAFRLYMEQSRATPCTRQNVSSAIQNKINSHAFTVSHQDFSCHEQHLNCPITLCIPETGVFVRNAKNSEICSLYDHNALTELIRRNAPHPLSREPFVPEMIVSKDECHFNLIEQYFCILATQNICTRI", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Effector_NleG that shares evolutionary origin and functional similarity; 2. The protein should be classified within Effector_NleG_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MPVILNFSSERVLSESELEALRHVGRVSQSEQLVVRGRTMRLHHISFMDSFSVEPVSGGLLDRLSARGHRLLAENLEIQLNRGHTFLQAFRLYMEQSRATPCTRQNVSSAIQNKINSHAFTVSHQDFSCHEQHLNCPITLCIPETGVFVRNAKNSEICSLYDHNALTELIRRNAPHPLSREPFVPEMIVSKDECHFNLIEQYFCILATQNICTRI" }, { "InterPro": [ { "InterPro-ID": "IPR003601", "InterPro-Name": "Topo_IA_2", "InterPro-Type": "DOMAIN", "Beg": 133, "End": 227 }, { "InterPro-ID": "IPR034144", "InterPro-Name": "TOPRIM_TopoIII", "InterPro-Type": "DOMAIN", "Beg": 10, "End": 153 }, { "InterPro-ID": "IPR006171", "InterPro-Name": "TOPRIM_dom", "InterPro-Type": "DOMAIN", "Beg": 9, "End": 133 }, { "InterPro-ID": "IPR023406", "InterPro-Name": "Topo_IA_AS", "InterPro-Type": "ACTIVE_SITE", "Beg": 308, "End": 322 }, { "InterPro-ID": "IPR013497", "InterPro-Name": "Topo_IA_cen", "InterPro-Type": "DOMAIN", "Beg": 391, "End": 407 }, { "InterPro-ID": "IPR013497", "InterPro-Name": "Topo_IA_cen", "InterPro-Type": "DOMAIN", "Beg": 107, "End": 120 }, { "InterPro-ID": "IPR013497", "InterPro-Name": "Topo_IA_cen", "InterPro-Type": "DOMAIN", "Beg": 491, "End": 505 }, { "InterPro-ID": "IPR013497", "InterPro-Name": "Topo_IA_cen", "InterPro-Type": "DOMAIN", "Beg": 313, "End": 322 }, { "InterPro-ID": "IPR013497", "InterPro-Name": "Topo_IA_cen", "InterPro-Type": "DOMAIN", "Beg": 197, "End": 215 }, { "InterPro-ID": "IPR000380", "InterPro-Name": "Topo_IA", "InterPro-Type": "FAMILY", "Beg": 10, "End": 607 }, { "InterPro-ID": "IPR003602", "InterPro-Name": "Topo_IA_DNA-bd_dom", "InterPro-Type": "DOMAIN", "Beg": 271, "End": 528 }, { "InterPro-ID": "IPR013826", "InterPro-Name": "Topo_IA_cen_sub3", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 279, "End": 405 }, { "InterPro-ID": "IPR006171", "InterPro-Name": "TOPRIM_dom", "InterPro-Type": "DOMAIN", "Beg": 11, "End": 141 }, { "InterPro-ID": "IPR013825", "InterPro-Name": "Topo_IA_cen_sub2", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 221, "End": 475 }, { "InterPro-ID": "IPR013497", "InterPro-Name": "Topo_IA_cen", "InterPro-Type": "DOMAIN", "Beg": 157, "End": 565 }, { "InterPro-ID": "IPR013497", "InterPro-Name": "Topo_IA_cen", "InterPro-Type": "DOMAIN", "Beg": 159, "End": 576 }, { "InterPro-ID": "IPR005739", "InterPro-Name": "TopoI_arch", "InterPro-Type": "FAMILY", "Beg": 13, "End": 606 }, { "InterPro-ID": "IPR013824", "InterPro-Name": "Topo_IA_cen_sub1", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 167, "End": 575 }, { "InterPro-ID": "IPR023405", "InterPro-Name": "Topo_IA_core_domain", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 10, "End": 580 } ], "response#1": "MNLCNVNNYYLIIAEKSKAAKKIAEALSEKPILCRKYNVSYWIIKDHNSSKYVIVPAAGHLFGLKGESGFPVYDADWKPLWEIDKNSYYTKRYYQLISSLSKYALGFINACDYDIEGSVIGYLIIKNLGDIKKAKRMKFSALTKSDILSAFRNISALDYDMINAGIARHKIDWLWGINVSRALMISLQDFAKKRVILSAGRVQSPTLVQVVNSEIERNLFIPLPKFTVSIIVKIKDYSLNIKVNKEFEKITEAKEFLNKLINKTVKVVEVENRVRLLERPSPFNLTDLQIEAGRIYGISPYNVERIAEDLYLDGLISYPRTNSQKIPSTISIYNIIKGLENSSYRKLVDLVRKITGGKYVVKQGIKDDPAHPAIHPTGEAPKNLPNSKFKIYDLIARRFLGSVSADAKLSNTIYTLKVSDFPLEFTVSYTKILERNWLDIYHFHNVKEDKPIFLSKGDEGKIVDGKVNISLSKPTSRYTKVSLLKWMESSNLGTEATRGRIIEILVKRKYLTNNGRYIIPTKLGFYIAEILNKFFPDIVDVRMTADMESKLEMIKTGKVLESKVIKENIEKLNKFIEEYKVNKDKVGESLAKALGLIKIVKCKYCDLEQYKDGLCKYHYEAKVRLLDAVEIWKERTKYDHKKILKRISSSKSTGKYVKDIVTYMLSSE", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Topo_IA_2, TOPRIM_TopoIII, TOPRIM_dom, Topo_IA_cen, Topo_IA_cen, Topo_IA_cen, Topo_IA_cen, Topo_IA_cen, Topo_IA_DNA-bd_dom, TOPRIM_dom, Topo_IA_cen, Topo_IA_cen that are essential for its biological function; 2. The protein should belong to Topo_IA, TopoI_arch that shares evolutionary origin and functional similarity; 3. The protein should be classified within Topo_IA_cen_sub3, Topo_IA_cen_sub2, Topo_IA_cen_sub1, Topo_IA_core_domain sharing conserved structural features; 4. The protein must have Topo_IA_AS that is conserved among related catalytic enzymes. The designed protein sequence is ", "reference": "MNLCNVNNYYLIIAEKSKAAKKIAEALSEKPILCRKYNVSYWIIKDHNSSKYVIVPAAGHLFGLKGESGFPVYDADWKPLWEIDKNSYYTKRYYQLISSLSKYALGFINACDYDIEGSVIGYLIIKNLGDIKKAKRMKFSALTKSDILSAFRNISALDYDMINAGIARHKIDWLWGINVSRALMISLQDFAKKRVILSAGRVQSPTLVQVVNSEIERNLFIPLPKFTVSIIVKIKDYSLNIKVNKEFEKITEAKEFLNKLINKTVKVVEVENRVRLLERPSPFNLTDLQIEAGRIYGISPYNVERIAEDLYLDGLISYPRTNSQKIPSTISIYNIIKGLENSSYRKLVDLVRKITGGKYVVKQGIKDDPAHPAIHPTGEAPKNLPNSKFKIYDLIARRFLGSVSADAKLSNTIYTLKVSDFPLEFTVSYTKILERNWLDIYHFHNVKEDKPIFLSKGDEGKIVDGKVNISLSKPTSRYTKVSLLKWMESSNLGTEATRGRIIEILVKRKYLTNNGRYIIPTKLGFYIAEILNKFFPDIVDVRMTADMESKLEMIKTGKVLESKVIKENIEKLNKFIEEYKVNKDKVGESLAKALGLIKIVKCKYCDLEQYKDGLCKYHYEAKVRLLDAVEIWKERTKYDHKKILKRISSSKSTGKYVKDIVTYMLSSE" }, { "InterPro": [ { "InterPro-ID": "IPR018108", "InterPro-Name": "Mitochondrial_sb/sol_carrier", "InterPro-Type": "REPEAT", "Beg": 1106, "End": 1193 }, { "InterPro-ID": "IPR018108", "InterPro-Name": "Mitochondrial_sb/sol_carrier", "InterPro-Type": "REPEAT", "Beg": 793, "End": 876 }, { "InterPro-ID": "IPR018108", "InterPro-Name": "Mitochondrial_sb/sol_carrier", "InterPro-Type": "REPEAT", "Beg": 32, "End": 72 }, { "InterPro-ID": "IPR018108", "InterPro-Name": "Mitochondrial_sb/sol_carrier", "InterPro-Type": "REPEAT", "Beg": 723, "End": 758 }, { "InterPro-ID": "IPR023395", "InterPro-Name": "Mt_carrier_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 31, "End": 93 }, { "InterPro-ID": "IPR023395", "InterPro-Name": "Mt_carrier_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1072, "End": 1199 }, { "InterPro-ID": "IPR018108", "InterPro-Name": "Mitochondrial_sb/sol_carrier", "InterPro-Type": "REPEAT", "Beg": 1109, "End": 1191 }, { "InterPro-ID": "IPR023395", "InterPro-Name": "Mt_carrier_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 722, "End": 878 }, { "InterPro-ID": "IPR018108", "InterPro-Name": "Mitochondrial_sb/sol_carrier", "InterPro-Type": "REPEAT", "Beg": 792, "End": 873 }, { "InterPro-ID": "IPR023395", "InterPro-Name": "Mt_carrier_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 13, "End": 100 }, { "InterPro-ID": "IPR023395", "InterPro-Name": "Mt_carrier_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 710, "End": 879 }, { "InterPro-ID": "IPR023395", "InterPro-Name": "Mt_carrier_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1092, "End": 1187 } ], "response#1": "MNELSVNDAFDDIEIESFDFIWEEWEEYKGDVPLWQHIFCGSIAGLMEHVFMYPLDTLKTYFQTNGHMKYNMIYDNCNTINNNNNNIYRGNNSSYKNTCDKNYKDMNNHRNMQTFKRNFCSSTNCDKCIINNFCKYKTNCYNVMAALHTKNNRYIHNIAEPLKNMANYKINTTNNNNVNNIINNNNNNNKKKSRNIFSYPSHTKQYRNVTYVVNKKMQQNLFNNYISNKCINDPFCCRTKTNVLNMKKDIHKFCHLSKEKYNNVFYQNDTYHPNIYGRKRKTLCRNKNNINLFKNHVHKKYCHSLDDQICHSKIKEDMRNLQNFKNYTCAKNMKRHLYSTVPFFNLKNKGNKNITLPYKEIRSKYILKNGYKSMYQRNAGYYKNLIKMQSAKKNRHQLLALRKCLMSEKKYTIIKNEPFIIRKKKNMRNEYFIGNMKGRCIINTSLNSYTLKRNCLDYHHFVNNLKNICYSIMNICYNIKNTILINPSLPINNNNNNNNNTKMDTFIKLINKCLYNNNAHKIDHKILLSNYLNLFKHTNYSYYYILNNFLKNNAPCTSRKNEWNIFSNFINVLKNKIITNNVDYIRNPNVRRNQILRNNYLYSFLRNYNKNLKRNTHMILNKLTSFKYSIPYIKNKYSNVLINNINTNNNTYSNRNVLNSIRYNNIYKNIMHPIFFPGYYNTIHFRYYNYFSRIIDDKDKGKNKNIINISTKRNNCSSIIRNNLSNLYKGVNVVVLGCIPAHALYFSTFEYSKKYFSRMTSNNSSLKMNNRNISTVSNDIKSEKSNFKLYDLNYFSIAVSGFLATLVHDLIITPIDTLKQRIQLGINKNSKDSLKLLKQNGIRSLYLSLPITLLMNIPYQIIMICTNEKMKKIYFEYICGLNTQNNKKNMENKVIDKVHDETRNQDNIGKDIKNDTYNMDKNGTFLRNQEMINKENRIYNSGALEKHVTSQEKEDKILQSVKQENVSSNNDIVNFYEGQSIYNNDAHNIIRDDINKMTHKNLENNIDNTINSNESDVNRIDNMTNDMNKECDIFSINKNNNSTVLYDQIMKRLEMNSSNKNFSLNFHDKIIRQESSPFEKENYNMNLKNIWIDNYKNDFFNKPFNHITSYFVCAGIGGGIAAVLTNPLDVIKTRIQTECFQTKGFNFFRIVSNIYYREGMRSFFKGSLARMALCIPASAVSWGTYETMKRFFKINFNTT", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should be classified within Mt_carrier_dom_sf, Mt_carrier_dom_sf, Mt_carrier_dom_sf, Mt_carrier_dom_sf, Mt_carrier_dom_sf, Mt_carrier_dom_sf sharing conserved structural features; 2. The protein should include one or more Mitochondrial_sb/sol_carrier, Mitochondrial_sb/sol_carrier, Mitochondrial_sb/sol_carrier, Mitochondrial_sb/sol_carrier, Mitochondrial_sb/sol_carrier, Mitochondrial_sb/sol_carrier that provide structural or functional support. The designed protein sequence is ", "reference": "MNELSVNDAFDDIEIESFDFIWEEWEEYKGDVPLWQHIFCGSIAGLMEHVFMYPLDTLKTYFQTNGHMKYNMIYDNCNTINNNNNNIYRGNNSSYKNTCDKNYKDMNNHRNMQTFKRNFCSSTNCDKCIINNFCKYKTNCYNVMAALHTKNNRYIHNIAEPLKNMANYKINTTNNNNVNNIINNNNNNNKKKSRNIFSYPSHTKQYRNVTYVVNKKMQQNLFNNYISNKCINDPFCCRTKTNVLNMKKDIHKFCHLSKEKYNNVFYQNDTYHPNIYGRKRKTLCRNKNNINLFKNHVHKKYCHSLDDQICHSKIKEDMRNLQNFKNYTCAKNMKRHLYSTVPFFNLKNKGNKNITLPYKEIRSKYILKNGYKSMYQRNAGYYKNLIKMQSAKKNRHQLLALRKCLMSEKKYTIIKNEPFIIRKKKNMRNEYFIGNMKGRCIINTSLNSYTLKRNCLDYHHFVNNLKNICYSIMNICYNIKNTILINPSLPINNNNNNNNNTKMDTFIKLINKCLYNNNAHKIDHKILLSNYLNLFKHTNYSYYYILNNFLKNNAPCTSRKNEWNIFSNFINVLKNKIITNNVDYIRNPNVRRNQILRNNYLYSFLRNYNKNLKRNTHMILNKLTSFKYSIPYIKNKYSNVLINNINTNNNTYSNRNVLNSIRYNNIYKNIMHPIFFPGYYNTIHFRYYNYFSRIIDDKDKGKNKNIINISTKRNNCSSIIRNNLSNLYKGVNVVVLGCIPAHALYFSTFEYSKKYFSRMTSNNSSLKMNNRNISTVSNDIKSEKSNFKLYDLNYFSIAVSGFLATLVHDLIITPIDTLKQRIQLGINKNSKDSLKLLKQNGIRSLYLSLPITLLMNIPYQIIMICTNEKMKKIYFEYICGLNTQNNKKNMENKVIDKVHDETRNQDNIGKDIKNDTYNMDKNGTFLRNQEMINKENRIYNSGALEKHVTSQEKEDKILQSVKQENVSSNNDIVNFYEGQSIYNNDAHNIIRDDINKMTHKNLENNIDNTINSNESDVNRIDNMTNDMNKECDIFSINKNNNSTVLYDQIMKRLEMNSSNKNFSLNFHDKIIRQESSPFEKENYNMNLKNIWIDNYKNDFFNKPFNHITSYFVCAGIGGGIAAVLTNPLDVIKTRIQTECFQTKGFNFFRIVSNIYYREGMRSFFKGSLARMALCIPASAVSWGTYETMKRFFKINFNTT" }, { "InterPro": [ { "InterPro-ID": "IPR010636", "InterPro-Name": "Cerato-ulmin_hydrophobin", "InterPro-Type": "FAMILY", "Beg": 1, "End": 95 }, { "InterPro-ID": "IPR036686", "InterPro-Name": "Hydrophobin_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 29, "End": 96 }, { "InterPro-ID": "IPR036686", "InterPro-Name": "Hydrophobin_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 18, "End": 97 }, { "InterPro-ID": "IPR010636", "InterPro-Name": "Cerato-ulmin_hydrophobin", "InterPro-Type": "FAMILY", "Beg": 30, "End": 93 }, { "InterPro-ID": "IPR010636", "InterPro-Name": "Cerato-ulmin_hydrophobin", "InterPro-Type": "FAMILY", "Beg": 31, "End": 94 } ], "response#1": "MQFTIATVLSLLTITLAAPAAMERQVPYTPCSGLYGTAQCCATDVLGVADLDCANPPATLANATHFESTCAAIGQRARCCVLPILGQDILCQTPAGL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Cerato-ulmin_hydrophobin, Cerato-ulmin_hydrophobin, Cerato-ulmin_hydrophobin that shares evolutionary origin and functional similarity; 2. The protein should be classified within Hydrophobin_sf, Hydrophobin_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MQFTIATVLSLLTITLAAPAAMERQVPYTPCSGLYGTAQCCATDVLGVADLDCANPPATLANATHFESTCAAIGQRARCCVLPILGQDILCQTPAGL" }, { "InterPro": [ { "InterPro-ID": "IPR000742", "InterPro-Name": "EGF-like_dom", "InterPro-Type": "DOMAIN", "Beg": 256, "End": 303 }, { "InterPro-ID": "IPR000742", "InterPro-Name": "EGF-like_dom", "InterPro-Type": "DOMAIN", "Beg": 171, "End": 209 }, { "InterPro-ID": "IPR000742", "InterPro-Name": "EGF-like_dom", "InterPro-Type": "DOMAIN", "Beg": 398, "End": 440 }, { "InterPro-ID": "IPR000742", "InterPro-Name": "EGF-like_dom", "InterPro-Type": "DOMAIN", "Beg": 444, "End": 486 }, { "InterPro-ID": "IPR000742", "InterPro-Name": "EGF-like_dom", "InterPro-Type": "DOMAIN", "Beg": 352, "End": 394 }, { "InterPro-ID": "IPR000742", "InterPro-Name": "EGF-like_dom", "InterPro-Type": "DOMAIN", "Beg": 128, "End": 168 }, { "InterPro-ID": "IPR000742", "InterPro-Name": "EGF-like_dom", "InterPro-Type": "DOMAIN", "Beg": 537, "End": 579 }, { "InterPro-ID": "IPR000742", "InterPro-Name": "EGF-like_dom", "InterPro-Type": "DOMAIN", "Beg": 490, "End": 533 }, { "InterPro-ID": "IPR000742", "InterPro-Name": "EGF-like_dom", "InterPro-Type": "DOMAIN", "Beg": 214, "End": 252 }, { "InterPro-ID": "IPR013032", "InterPro-Name": "EGF-like_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 229, "End": 244 }, { "InterPro-ID": "IPR050751", "InterPro-Name": "ECM_structural_protein", "InterPro-Type": "FAMILY", "Beg": 347, "End": 575 }, { "InterPro-ID": "IPR000742", "InterPro-Name": "EGF-like_dom", "InterPro-Type": "DOMAIN", "Beg": 238, "End": 251 }, { "InterPro-ID": "IPR000742", "InterPro-Name": "EGF-like_dom", "InterPro-Type": "DOMAIN", "Beg": 211, "End": 252 }, { "InterPro-ID": "IPR001881", "InterPro-Name": "EGF-like_Ca-bd_dom", "InterPro-Type": "DOMAIN", "Beg": 349, "End": 394 }, { "InterPro-ID": "IPR001881", "InterPro-Name": "EGF-like_Ca-bd_dom", "InterPro-Type": "DOMAIN", "Beg": 168, "End": 209 }, { "InterPro-ID": "IPR001881", "InterPro-Name": "EGF-like_Ca-bd_dom", "InterPro-Type": "DOMAIN", "Beg": 487, "End": 539 }, { "InterPro-ID": "IPR001881", "InterPro-Name": "EGF-like_Ca-bd_dom", "InterPro-Type": "DOMAIN", "Beg": 211, "End": 252 }, { "InterPro-ID": "IPR001881", "InterPro-Name": "EGF-like_Ca-bd_dom", "InterPro-Type": "DOMAIN", "Beg": 253, "End": 303 }, { "InterPro-ID": "IPR000152", "InterPro-Name": "EGF-type_Asp/Asn_hydroxyl_site", "InterPro-Type": "PTM", "Beg": 229, "End": 240 } ], "response#1": "MKANRIWCFFAWRMVVRASFLKEMDSIFVSAIRQNVQHTHSALLAKLKEPPDPDDENSWLCRISKKYDACGSREYSDKGLKGTYCPEDFCCSKTACFYGSCGSWCHDNWALCSSSIIYHDEYSYGKCNCKRFQENCDVNAICVHANREDGGAYCQCKEGYWGDGKSCKIDFCQLQPCGAGTCTRTDEGYKCDCPETHKLIVVEDKETCKAKPDFCAEEPCGPPSMVENCVNTDDSYECVCKQGYEVRNGRCEEIDLCADKPCGPDEGVHECVTERQPKLRYRCTCKAGFDLTTLPDGVSQKCLKNFCYEEPCGTRDLVESCKSKAYGYSCLCAAGAMVQVINGKEKCIKADLCRNDPCGPETAVIQCYSHGTSYRCLCKAGYTEVFVNGKSSCQKGDPCTLNMCGGNEAVQECTTDGTAYGCTCKPGYSIAIKHGQKFCNPEEECASHCGSAAAVKSCEILDSGGYQCTCNPGYVMRYSDYVKGCVEGNQCSLNPCGEQEAVQRCIPEGDTYDCECNPGFVKRVLPDGNFICADPASCVGNPCGSSDAVDACIAGTSTYTCRCKDGYTPQSIGSKLQCLPESTDQTDFDSKHKPEDNKGRYSKGTIALVVVGCVALLGIIAGGISYARNRGGERDDEDLAPPPRSTRERRLSSMGEGFENASWASSVSMIPSAPAPPPSGGIWS", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more EGF-like_dom, EGF-like_dom, EGF-like_dom, EGF-like_dom, EGF-like_dom, EGF-like_dom, EGF-like_dom, EGF-like_dom, EGF-like_dom, EGF-like_dom, EGF-like_dom, EGF-like_Ca-bd_dom, EGF-like_Ca-bd_dom, EGF-like_Ca-bd_dom, EGF-like_Ca-bd_dom, EGF-like_Ca-bd_dom that are essential for its biological function; 2. The protein should belong to ECM_structural_protein that shares evolutionary origin and functional similarity; 3. The protein should contain EGF-like_CS that is preserved across related proteins; 4. The protein should contain EGF-type_Asp/Asn_hydroxyl_site that allow regulation through chemical modifications. The designed protein sequence is ", "reference": "MKANRIWCFFAWRMVVRASFLKEMDSIFVSAIRQNVQHTHSALLAKLKEPPDPDDENSWLCRISKKYDACGSREYSDKGLKGTYCPEDFCCSKTACFYGSCGSWCHDNWALCSSSIIYHDEYSYGKCNCKRFQENCDVNAICVHANREDGGAYCQCKEGYWGDGKSCKIDFCQLQPCGAGTCTRTDEGYKCDCPETHKLIVVEDKETCKAKPDFCAEEPCGPPSMVENCVNTDDSYECVCKQGYEVRNGRCEEIDLCADKPCGPDEGVHECVTERQPKLRYRCTCKAGFDLTTLPDGVSQKCLKNFCYEEPCGTRDLVESCKSKAYGYSCLCAAGAMVQVINGKEKCIKADLCRNDPCGPETAVIQCYSHGTSYRCLCKAGYTEVFVNGKSSCQKGDPCTLNMCGGNEAVQECTTDGTAYGCTCKPGYSIAIKHGQKFCNPEEECASHCGSAAAVKSCEILDSGGYQCTCNPGYVMRYSDYVKGCVEGNQCSLNPCGEQEAVQRCIPEGDTYDCECNPGFVKRVLPDGNFICADPASCVGNPCGSSDAVDACIAGTSTYTCRCKDGYTPQSIGSKLQCLPESTDQTDFDSKHKPEDNKGRYSKGTIALVVVGCVALLGIIAGGISYARNRGGERDDEDLAPPPRSTRERRLSSMGEGFENASWASSVSMIPSAPAPPPSGGIWS" }, { "InterPro": [ { "InterPro-ID": "IPR027381", "InterPro-Name": "LytR/CpsA/Psr_C", "InterPro-Type": "DOMAIN", "Beg": 77, "End": 162 } ], "response#1": "MLVTVGSMNERVPDSSGLPLRAMVMVLLFLGVVFLLLVWQALGSSPNSEDDSSAISTMTTTTAAPTSTSVKPAAPRAEVRVYNISGTEGAAARTADRLKAAGFTVTDVGNLSLPDVAATTVYYTEVEGERATADAVGRTLGAAVELRLPELSDQPPGVIVVVTG", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more LytR/CpsA/Psr_C that are essential for its biological function. The designed protein sequence is ", "reference": "MLVTVGSMNERVPDSSGLPLRAMVMVLLFLGVVFLLLVWQALGSSPNSEDDSSAISTMTTTTAAPTSTSVKPAAPRAEVRVYNISGTEGAAARTADRLKAAGFTVTDVGNLSLPDVAATTVYYTEVEGERATADAVGRTLGAAVELRLPELSDQPPGVIVVVTG" }, { "InterPro": [ { "InterPro-ID": "IPR038372", "InterPro-Name": "PA/PA-X_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1, "End": 198 }, { "InterPro-ID": "IPR001009", "InterPro-Name": "PA/PA-X", "InterPro-Type": "FAMILY", "Beg": 21, "End": 204 } ], "response#1": "MEDFVRQCFNPMIVELAEKAMKEYGEDPKIETNKFAAICTHLEVCFMYSDFHFIDERGESIIVESGDPNALLKHRFEIIEGRDRIMAWTVVNSICNTTGVEKPKFLPDLYDYKENRFIEIGVTRREVHIYYLEKANKIKSEKTHIHIFSFTGEEMATKADYTLDEESRARIKTRLFTIRQEMASRSLWDSFVSPKEAKRQLKKNLRLQELCASLPTKVSHRTSPALKTLEPM", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to PA/PA-X that shares evolutionary origin and functional similarity; 2. The protein should be classified within PA/PA-X_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MEDFVRQCFNPMIVELAEKAMKEYGEDPKIETNKFAAICTHLEVCFMYSDFHFIDERGESIIVESGDPNALLKHRFEIIEGRDRIMAWTVVNSICNTTGVEKPKFLPDLYDYKENRFIEIGVTRREVHIYYLEKANKIKSEKTHIHIFSFTGEEMATKADYTLDEESRARIKTRLFTIRQEMASRSLWDSFVSPKEAKRQLKKNLRLQELCASLPTKVSHRTSPALKTLEPM" }, { "InterPro": [ { "InterPro-ID": "IPR013154", "InterPro-Name": "ADH-like_N", "InterPro-Type": "DOMAIN", "Beg": 36, "End": 154 }, { "InterPro-ID": "IPR047109", "InterPro-Name": "CAD-like", "InterPro-Type": "FAMILY", "Beg": 14, "End": 352 }, { "InterPro-ID": "IPR013149", "InterPro-Name": "ADH-like_C", "InterPro-Type": "DOMAIN", "Beg": 194, "End": 317 }, { "InterPro-ID": "IPR036291", "InterPro-Name": "NAD(P)-bd_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 156, "End": 321 }, { "InterPro-ID": "IPR011032", "InterPro-Name": "GroES-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 19, "End": 185 }, { "InterPro-ID": "IPR047109", "InterPro-Name": "CAD-like", "InterPro-Type": "FAMILY", "Beg": 8, "End": 356 }, { "InterPro-ID": "IPR020843", "InterPro-Name": "PKS_ER", "InterPro-Type": "DOMAIN", "Beg": 23, "End": 351 }, { "InterPro-ID": "IPR002328", "InterPro-Name": "ADH_Zn_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 71, "End": 85 } ], "response#1": "MAISPEVEHPNKAFGFAARDPSGLLSPFNFSRRATGEHDVQFKVLYCGICHSDLHMIKNEWGFTKYPIVPGHEIVGVVTEVGSKVEKFKVGDKVGVGCLVGSCRKCDMCSQDLENYCPDQILTYSATYTDGTTTYGGYSSLMVADEHFVIRWPENLPMDIGAPLLCAGITTYSPLRHFGLDKPGTHVGIVGLGGLGHVAVKFAKAFGAKVTVISTSEGKKQEAVEKLGADAFLVSRDPEQMQAAAATLDGIIDTVSAVHPILPLVNLLKSQGKLIMVGAPEKPIELPVFPLLLGRKIVAGSAIGGLKETQDMIDFAAKHNILPDVELIPMDYVNTAMERLLKADVKYRFVIDICNTLKSA", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more ADH-like_N, ADH-like_C, PKS_ER that are essential for its biological function; 2. The protein should belong to CAD-like, CAD-like that shares evolutionary origin and functional similarity; 3. The protein should be classified within NAD(P)-bd_dom_sf, GroES-like_sf sharing conserved structural features; 4. The protein should contain ADH_Zn_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MAISPEVEHPNKAFGFAARDPSGLLSPFNFSRRATGEHDVQFKVLYCGICHSDLHMIKNEWGFTKYPIVPGHEIVGVVTEVGSKVEKFKVGDKVGVGCLVGSCRKCDMCSQDLENYCPDQILTYSATYTDGTTTYGGYSSLMVADEHFVIRWPENLPMDIGAPLLCAGITTYSPLRHFGLDKPGTHVGIVGLGGLGHVAVKFAKAFGAKVTVISTSEGKKQEAVEKLGADAFLVSRDPEQMQAAAATLDGIIDTVSAVHPILPLVNLLKSQGKLIMVGAPEKPIELPVFPLLLGRKIVAGSAIGGLKETQDMIDFAAKHNILPDVELIPMDYVNTAMERLLKADVKYRFVIDICNTLKSA" }, { "InterPro": [ { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 14, "End": 88 }, { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 14, "End": 91 } ], "response#1": "PTKMTRRTEPASSCSTGSLDCCNSSGDATDTSITTLLAGIGLPIGSVTGLVGVTCSPITGIGLGGSGCSSEALCCSNNSFKGLVALGCVPVDLSL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Hydrophobin, Hydrophobin that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "PTKMTRRTEPASSCSTGSLDCCNSSGDATDTSITTLLAGIGLPIGSVTGLVGVTCSPITGIGLGGSGCSSEALCCSNNSFKGLVALGCVPVDLSL" }, { "InterPro": [ { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 28, "End": 105 }, { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 28, "End": 102 }, { "InterPro-ID": "IPR019778", "InterPro-Name": "Hydrophobin_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 79, "End": 90 } ], "response#1": "MFAQSFIITALAALAVASPLQVRTSDKCNTGTVHCCNSMKKSDSADISKIASLLQLDVKGVVGDVGLQCSPLVSLVGGGSKCSGQTVCCDQTKFNGLVNIGCSPINVGL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Hydrophobin, Hydrophobin that shares evolutionary origin and functional similarity; 2. The protein should contain Hydrophobin_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MFAQSFIITALAALAVASPLQVRTSDKCNTGTVHCCNSMKKSDSADISKIASLLQLDVKGVVGDVGLQCSPLVSLVGGGSKCSGQTVCCDQTKFNGLVNIGCSPINVGL" }, { "InterPro": [ { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 48, "End": 123 } ], "response#1": "MRLTPLLAALALPLLTVLATPLTPVGEAEVVEVDVAPRQISLNPASSCPKGQLWCCVSLDLVSNSLIAGLLVTLGILDPTGINTAGVQCTPLSWPFQMSCGNKDLCCDPDLPVVGLLLKLNCRSVNPLL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Hydrophobin that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MRLTPLLAALALPLLTVLATPLTPVGEAEVVEVDVAPRQISLNPASSCPKGQLWCCVSLDLVSNSLIAGLLVTLGILDPTGINTAGVQCTPLSWPFQMSCGNKDLCCDPDLPVVGLLLKLNCRSVNPLL" }, { "InterPro": [ { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 36, "End": 130 }, { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 36, "End": 127 } ], "response#1": "MFSNAAAFSTVALATYAAATPAVVARTEPHPSSSNCGTTTIECCKDVGTATSLESPLKSAFIQHGLVSSLLVALGVVKVVDVVLGVVVDPNVVLGLTCSTVAVGGSCNAQQVCCENVAFNGLVNVGCTAIDIL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Hydrophobin, Hydrophobin that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MFSNAAAFSTVALATYAAATPAVVARTEPHPSSSNCGTTTIECCKDVGTATSLESPLKSAFIQHGLVSSLLVALGVVKVVDVVLGVVVDPNVVLGLTCSTVAVGGSCNAQQVCCENVAFNGLVNVGCTAIDIL" }, { "InterPro": [ { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 48, "End": 121 }, { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 48, "End": 124 }, { "InterPro-ID": "IPR019778", "InterPro-Name": "Hydrophobin_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 98, "End": 109 } ], "response#1": "MILLAFSGELFKRINTSPIVHVERRTNPTTTVTVTTKPSPTPISPNQCNTNKIQCCNSVQSSDAPLLTGLLGLLGIVLQGVIPIGVTCSPISVIGIGGNSCSAQTVCCENNTFNGVIAIGCTPINIDL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Hydrophobin, Hydrophobin that shares evolutionary origin and functional similarity; 2. The protein should contain Hydrophobin_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MILLAFSGELFKRINTSPIVHVERRTNPTTTVTVTTKPSPTPISPNQCNTNKIQCCNSVQSSDAPLLTGLLGLLGIVLQGVIPIGVTCSPISVIGIGGNSCSAQTVCCENNTFNGVIAIGCTPINIDL" }, { "InterPro": [ { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 30, "End": 104 }, { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 30, "End": 107 } ], "response#1": "MLFNTFVVTALASLAAATPTRRNEPAAGSCSTGELQCCKSVQSADSKSLTSLFGLLGLVVGDITGLVGVTCSPVTVVGAGGAQCNAQAVCCNDNSFNGLIALGCTPINLNL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Hydrophobin, Hydrophobin that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MLFNTFVVTALASLAAATPTRRNEPAAGSCSTGELQCCKSVQSADSKSLTSLFGLLGLVVGDITGLVGVTCSPVTVVGAGGAQCNAQAVCCNDNSFNGLIALGCTPINLNL" }, { "InterPro": [ { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 30, "End": 107 }, { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 30, "End": 109 } ], "response#1": "MFAAPATMLVLAALAALSSAIPAAQTASKCSTGPVQCCDSVEHHTQPHVNNLLLGLEHFGLVKGLVGGLTGNVGIKCNPILLSSNDCTAQSVCCEHVHFKGNIAVGCTPANIDIL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Hydrophobin, Hydrophobin that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MFAAPATMLVLAALAALSSAIPAAQTASKCSTGPVQCCDSVEHHTQPHVNNLLLGLEHFGLVKGLVGGLTGNVGIKCNPILLSSNDCTAQSVCCEHVHFKGNIAVGCTPANIDIL" }, { "InterPro": [ { "InterPro-ID": "IPR019778", "InterPro-Name": "Hydrophobin_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 104, "End": 115 }, { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 50, "End": 130 }, { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 50, "End": 127 } ], "response#1": "MFAKSATIAIVLAALAGFSAAVPTADCRTSKTCSSGKVALVAPAAPVGSCSTGKVQCCNSVEHSTQPHVNNLLLGLEHFGLVKGLIGGLTGNVGIQCSPLLLSGNSCTAQTACCENVHFNGLIAVGCSPVNLSLL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Hydrophobin, Hydrophobin that shares evolutionary origin and functional similarity; 2. The protein should contain Hydrophobin_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MFAKSATIAIVLAALAGFSAAVPTADCRTSKTCSSGKVALVAPAAPVGSCSTGKVQCCNSVEHSTQPHVNNLLLGLEHFGLVKGLIGGLTGNVGIQCSPLLLSGNSCTAQTACCENVHFNGLIAVGCSPVNLSLL" }, { "InterPro": [ { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 28, "End": 102 }, { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 28, "End": 105 } ], "response#1": "MFTEQVLNVIILLQTATVTATAIPASGCNAGDVQCCKSVQKADSAGGAALLGLVGIVLSNLDVFIGGDCSPITAIGVGGTSCSSQAVCCENNSFNGLIALGCVPINLSL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Hydrophobin, Hydrophobin that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MFTEQVLNVIILLQTATVTATAIPASGCNAGDVQCCKSVQKADSAGGAALLGLVGIVLSNLDVFIGGDCSPITAIGVGGTSCSSQAVCCENNSFNGLIALGCVPINLSL" }, { "InterPro": [ { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 39, "End": 124 }, { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 39, "End": 121 }, { "InterPro-ID": "IPR019778", "InterPro-Name": "Hydrophobin_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 98, "End": 109 } ], "response#1": "MFNKQTNAIVLLFTFALFATLAVATPTIVARTGGSGSSCPTTDIKCCSHVGTFSEVQGYIDDDTKVKLIPALLGLLGATIDVVLGVVLGVTCSSISVGSSCSATTVCCENVVFNGLINVGCTAIDIL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Hydrophobin, Hydrophobin that shares evolutionary origin and functional similarity; 2. The protein should contain Hydrophobin_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MFNKQTNAIVLLFTFALFATLAVATPTIVARTGGSGSSCPTTDIKCCSHVGTFSEVQGYIDDDTKVKLIPALLGLLGATIDVVLGVVLGVTCSSISVGSSCSATTVCCENVVFNGLINVGCTAIDIL" }, { "InterPro": [ { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 37, "End": 120 }, { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 37, "End": 117 } ], "response#1": "MFFFNTKPIVFLVVLSVVATFAAATPAMLARGGGSSCAPSTSLKCCDHVGTFSEVSPYINPLELVGVIAALLGLVGGLFTSVTLALTCSGIDIGGSCNSQTVCCENVVFNGLVNVGCTAIDIL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Hydrophobin, Hydrophobin that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MFFFNTKPIVFLVVLSVVATFAAATPAMLARGGGSSCAPSTSLKCCDHVGTFSEVSPYINPLELVGVIAALLGLVGGLFTSVTLALTCSGIDIGGSCNSQTVCCENVVFNGLVNVGCTAIDIL" }, { "InterPro": [ { "InterPro-ID": "IPR020400", "InterPro-Name": "Cecropin_insect", "InterPro-Type": "FAMILY", "Beg": 1, "End": 59 }, { "InterPro-ID": "IPR000875", "InterPro-Name": "Cecropin", "InterPro-Type": "FAMILY", "Beg": 29, "End": 57 } ], "response#1": "MNFSKVFALVLLIGLVLLTGHTEAGGLKKLGKKLEGVGKRVFKASEKALPVVTGYKAIGK", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Cecropin_insect, Cecropin that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MNFSKVFALVLLIGLVLLTGHTEAGGLKKLGKKLEGVGKRVFKASEKALPVVTGYKAIGK" }, { "InterPro": [ { "InterPro-ID": "IPR036686", "InterPro-Name": "Hydrophobin_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 18, "End": 98 }, { "InterPro-ID": "IPR010636", "InterPro-Name": "Cerato-ulmin_hydrophobin", "InterPro-Type": "FAMILY", "Beg": 1, "End": 96 }, { "InterPro-ID": "IPR036686", "InterPro-Name": "Hydrophobin_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 28, "End": 97 }, { "InterPro-ID": "IPR010636", "InterPro-Name": "Cerato-ulmin_hydrophobin", "InterPro-Type": "FAMILY", "Beg": 28, "End": 94 }, { "InterPro-ID": "IPR010636", "InterPro-Name": "Cerato-ulmin_hydrophobin", "InterPro-Type": "FAMILY", "Beg": 29, "End": 95 } ], "response#1": "MQFFTTVVLFAAAAMALPGGQQSRPYDPCPNNLLSVPQCCDTDALGLVGLGCVAPPNNRPASPRAFADCCHASSRRPKCCAVTTGLEASVLCDDPAGF", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Cerato-ulmin_hydrophobin, Cerato-ulmin_hydrophobin, Cerato-ulmin_hydrophobin that shares evolutionary origin and functional similarity; 2. The protein should be classified within Hydrophobin_sf, Hydrophobin_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MQFFTTVVLFAAAAMALPGGQQSRPYDPCPNNLLSVPQCCDTDALGLVGLGCVAPPNNRPASPRAFADCCHASSRRPKCCAVTTGLEASVLCDDPAGF" }, { "InterPro": [ { "InterPro-ID": "IPR010982", "InterPro-Name": "Lambda_DNA-bd_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 17, "End": 83 }, { "InterPro-ID": "IPR001387", "InterPro-Name": "Cro/C1-type_HTH", "InterPro-Type": "DOMAIN", "Beg": 25, "End": 75 }, { "InterPro-ID": "IPR001387", "InterPro-Name": "Cro/C1-type_HTH", "InterPro-Type": "DOMAIN", "Beg": 26, "End": 80 }, { "InterPro-ID": "IPR010982", "InterPro-Name": "Lambda_DNA-bd_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1, "End": 91 }, { "InterPro-ID": "IPR001387", "InterPro-Name": "Cro/C1-type_HTH", "InterPro-Type": "DOMAIN", "Beg": 25, "End": 80 }, { "InterPro-ID": "IPR001387", "InterPro-Name": "Cro/C1-type_HTH", "InterPro-Type": "DOMAIN", "Beg": 27, "End": 76 }, { "InterPro-ID": "IPR050807", "InterPro-Name": "Bact_TransReg_Diox", "InterPro-Type": "FAMILY", "Beg": 23, "End": 97 } ], "response#1": "MMGNKLTLPAELPDEQDLRAVLAYNMRLFRVNKGWSQEELARQCGLDRTYVSAVERKRWNIALSNIEKMAAALGVAAYQLLLPPQERLKLMTNSADTRQMPSESGI", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Cro/C1-type_HTH, Cro/C1-type_HTH, Cro/C1-type_HTH, Cro/C1-type_HTH that are essential for its biological function; 2. The protein should belong to Bact_TransReg_Diox that shares evolutionary origin and functional similarity; 3. The protein should be classified within Lambda_DNA-bd_dom_sf, Lambda_DNA-bd_dom_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MMGNKLTLPAELPDEQDLRAVLAYNMRLFRVNKGWSQEELARQCGLDRTYVSAVERKRWNIALSNIEKMAAALGVAAYQLLLPPQERLKLMTNSADTRQMPSESGI" }, { "InterPro": [ { "InterPro-ID": "IPR010636", "InterPro-Name": "Cerato-ulmin_hydrophobin", "InterPro-Type": "FAMILY", "Beg": 5, "End": 86 }, { "InterPro-ID": "IPR036686", "InterPro-Name": "Hydrophobin_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 18, "End": 97 }, { "InterPro-ID": "IPR036686", "InterPro-Name": "Hydrophobin_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 29, "End": 90 }, { "InterPro-ID": "IPR010636", "InterPro-Name": "Cerato-ulmin_hydrophobin", "InterPro-Type": "FAMILY", "Beg": 31, "End": 85 }, { "InterPro-ID": "IPR010636", "InterPro-Name": "Cerato-ulmin_hydrophobin", "InterPro-Type": "FAMILY", "Beg": 32, "End": 85 } ], "response#1": "MRIDILATAALLAQLASASPAPAKRQTYIACSGLYGTAQCCATDVLGLVNLDCGNPPSLPTSPDEFSSVCSAIGQRARCCVLPIVSFMRLIIQDYPISY", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Cerato-ulmin_hydrophobin, Cerato-ulmin_hydrophobin, Cerato-ulmin_hydrophobin that shares evolutionary origin and functional similarity; 2. The protein should be classified within Hydrophobin_sf, Hydrophobin_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MRIDILATAALLAQLASASPAPAKRQTYIACSGLYGTAQCCATDVLGLVNLDCGNPPSLPTSPDEFSSVCSAIGQRARCCVLPIVSFMRLIIQDYPISY" }, { "InterPro": [ { "InterPro-ID": "IPR011060", "InterPro-Name": "RibuloseP-bd_barrel", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 51, "End": 303 }, { "InterPro-ID": "IPR013785", "InterPro-Name": "Aldolase_TIM", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 50, "End": 308 }, { "InterPro-ID": "IPR044524", "InterPro-Name": "Isoase_HisA-like", "InterPro-Type": "FAMILY", "Beg": 51, "End": 308 }, { "InterPro-ID": "IPR006062", "InterPro-Name": "His_biosynth", "InterPro-Type": "FAMILY", "Beg": 54, "End": 288 }, { "InterPro-ID": "IPR011858", "InterPro-Name": "His6-like_euk", "InterPro-Type": "FAMILY", "Beg": 50, "End": 304 } ], "response#1": "MRSPASTPSIRGGAFASSPILRHNHLPFLRLNPPSSSPTRSSPPSIQCSVQFRPCIDIHKGKVKQIVGSTLKDLKDDDGSDPITNFESDKSAAEYATLYKQDGLKGGHVIMLGADPFSKAASLEALHAYPGGLQVGGGINSDNCLSYIEEGASHVIVTSYVFNNGQMDLERLKDLVRIVGKERLVLDLSCRKKEGKYAIVTDRWQKFSDVSLDAKVMEFLANFADEFLVHGVDVEGKKLGIDEELVALLGKHSPIPVTYAGGVTVMDDLERIRTAGMDNVDVTVGSALDIFGGNLAYKDVVAWHNQQKVSVA", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Isoase_HisA-like, His_biosynth, His6-like_euk that shares evolutionary origin and functional similarity; 2. The protein should be classified within RibuloseP-bd_barrel, Aldolase_TIM sharing conserved structural features. The designed protein sequence is ", "reference": "MRSPASTPSIRGGAFASSPILRHNHLPFLRLNPPSSSPTRSSPPSIQCSVQFRPCIDIHKGKVKQIVGSTLKDLKDDDGSDPITNFESDKSAAEYATLYKQDGLKGGHVIMLGADPFSKAASLEALHAYPGGLQVGGGINSDNCLSYIEEGASHVIVTSYVFNNGQMDLERLKDLVRIVGKERLVLDLSCRKKEGKYAIVTDRWQKFSDVSLDAKVMEFLANFADEFLVHGVDVEGKKLGIDEELVALLGKHSPIPVTYAGGVTVMDDLERIRTAGMDNVDVTVGSALDIFGGNLAYKDVVAWHNQQKVSVA" }, { "InterPro": [ { "InterPro-ID": "IPR026306", "InterPro-Name": "RSBN1/Dpy-21", "InterPro-Type": "FAMILY", "Beg": 1976, "End": 2536 }, { "InterPro-ID": "IPR001368", "InterPro-Name": "TNFR/NGFR_Cys_rich_reg", "InterPro-Type": "DOMAIN", "Beg": 1354, "End": 1400 } ], "response#1": "MSSSASSRSVESSPARSSAASSSSSSEQHVAGGRLSSSQVNSTSVSSQSSSSRRARDDWCQSSHSSSSGSASSDSSSFCRGSRDSSSASVSRGTWRVDRDSFSVSGTSRSRLLSFPGSSHQPNRTENASHPDDLSSFRDSCVRRDTDTAERVATVRVNFPSRQNNDSSSGTCTSPISSSCDYSATESHSSASPSLRPSSGVVSSSRSSSRPGAALPLSVSSSSLLSQKKGRRKEAESLVDSSSTHSKQRDSAACRLLRVSPSASETTSVCRMSSGSGTARVARLEHQVEASFNPEEYPECFVCHPSLVAPSRLRETGKAQRDQRGLYTRFGRLHLSPQRLSVEATCVYGHCSSPPLSHLGAGAENSEGTNDLALSNEDKKGETQNARKRSASAFSESVSFREDTRRGSLLSVSLPAASSVLGSDLLSPSLREVYRHRGDSYLSRFKGGSSLLPAPRRSSCCVSSVPPFPESEKRNAGSDRRPTRSASLSSLLPNQPPASSSRRPSCSFSLLPAPLFSFGRRDPGGFDTDDACLRHDKESGVCTPAGTDLFVDVSREIRIIDALSEIQKESLIAAHCLDHSAALSEASAPLDASPSSSTVPHVSPSSVSSSLGRLHSSEKQTDCLRLRGSRGLQRRQRHTCSVAPSSADPLAPSFLQPHPSSKQLNQLLDHWRSGRVSVPRGSRVETRGEASCHAFDASPSCPPCSSQSLGSAAPNNACSRAAYGARLEAQANVLSNLDSRQGGRKEEEAADGGEDGEEGSRRLSQQTRPEGVEDRRGWTAIEEFNDCDGNVPRRSQLADFLRTCHVSRSQVGSVLGTHAKESSQDGEGEDQTGEDKGDAGDRCVTHEDDGGILCRSLESRKSEAKGYAMRKGSQKERVEKERMEGSPAKRRGPFPGGGETWTLPAYEADGLSSPRGREVVASCSSAGRLETSSKDASLSCSAFAGSENERLRAWALQAPSAEAFDRVDLVVRRLGLPQKTLQEKQTRPGDPGRSLLDEKPTVSEEKTKDRGGVAVPALASAAVKPFGNNEGGDGSAWSRLTNDLEAFRWKQMMQPSSTFLSAPVAKRGRALSPQGGADSEGRGESEEGRRGGCAAARRRAGAEEETRELLEAYEAARVKILAKSDEEAMQAAVSNSLHQSERVLGKLENVTRRLLEATCQSPKTKPISCSSSSAPSSSSSSSFSSSSSSSDCFSGDGASEATTVAPNGSAALSPPDGEKQRPSVGQRDALQAKLWESERELNSKDAEIGRTLQAVADSQAELARCRQELQESRSKALEAAKKAAVAQRMVRLLHQRRQEDRERWRQAVEECYRSRRSDQEADEDKQETDSASKKTDGNRNTESSLSRTSSCSSCSSSCSSFSSGSSSCSSSCSSCSSSCSSSCSSCSSSCSSSCSSSSSCSASCCGSTLLASASRPSSLSSAWFPAEDELPEVEELVAEYEAETRGYESRIAELQTLLEARNSAVEQLEVKGEALRNEVAFLQSMTEELRRARDAEEDCVLGALRQQVEEAEQSTLRLGREKDQLRSELDRVRASFTKQLAALETLNCRLRKEKEIFAEREKSQRRLHQEEHERMTRELHALRSEKEAGEAELLVLATAKAAAEMKCQQLEQQQETLKIHQERLCGNLLHLKNKAHGLSLSRRNHVSRQDSTNQAPSAECVDASSRRRVTSSVSEDDPSSALWSSSAERTDTSGNLFSSLSGPRSRSSGSPGESFERSHSSSCLASSPSCPSAASGSKEETSGSLQRMRSSASGSSKSVSVSSVNVLTYSEGPPLQSRSEFASSRPSFPSPSSASLSSESHRACGAPQAKEAANFFERLSSRLQSMREESERRQHALPGLPPHARSLEATQRQGRDSELGSFGEGPQGRAHSRQSGGDSAPSSFPAVPSQSGSSSASRGTEAFLGLAGDLERKDENASRFLSDSLGAQGQAQTDRGPMGFTARDEAGHLQGLPSGENDESITSSAFFARARQMKNSGKAVHSPDPRKDSGSESSDSQDPSAEEEEGDERAEEEEGDERAEDEEEDEREEEEEEEDEREEEEEEEDEREEEEEEGDERAEDEEEDEREEEEEEDERVEEEEEEDEREEEESVRGEGESGSGSISSSRRSRRSTPERGTRISSFSPRNGAGRKTSRSSFSGESRTSSEGSRRSGTSRSRDYASSPTSSRRDGETSPPGKSGHRRKRSNSASSEDSSRSAPQSDVSVNQVYAHPAALGSKTSGVRTPQASASRGAPASTAGATGGRPVSGSHPSRATERRDDGRQAKSVKKKEPQTRVRSRPRPESQESKTPESADSGATLDRGARHRETPRRNSESEEARPGEGERTCVSPASGGEKRRNFVSRDETSMGASRADHQETMKNAKLSTISRKRTPSPVAIYRVSPSSSSNASASQRESRAAKSSNTGMSSSSSFSLYRPHDFSREGSQGGPPPDFKFSEASSSSSSSISSSHSSSVPFPFSALASGSSSSAPAKTEKKVECEGAASSLSSLGASSSCHERVDPELRQQRGNTAEAQQKSDPSTVSPRKHSDEQRTEREGKTRRPEDSGCATQHRNPETRGRPPQPSLVAIQEGHPTSPFSVLPQHPPAARQLQPLSPSLRLSPSSVRCKQCAGVSSRFPHAHDLRVEPCCHRRCEGRNCSSGEESGEREQAVRCRHNPIPGRGPPVTENTVCHAPSDQGRTLAGGPRLAGSRHKEPENLSSASSCPSSSCPRAARQREGEGEKRHRETPSVKREENRKSSRTGEASSSVSIPNERSSDDVSPSGLERLSFGCTYTRYGREGREEKSPLLAPGHAANQRLTDGRSLHSFPDERKPSDMERRVASHMLPEKRTEEASPAAASGPGQRRLCGEACRPETGDKCGERQPVSSFSREKGTSSVQARRDESDEPRFVEKLRIGEQNPSLVLREMEDLRVTSRTAAEIDACMRHARLACRRAEPVSACPPSPFSFRGSVGDQLSPCESPHGPSHGASVSCVSAPTAIPPACCWLPEETAARGHRGNCVHANWQALADEELLEEEDGDTRRGEGEEREAREFGDRGERDDGHRAARGEVGCGVLGGRRERREETGRRRDTTRIPESCGGGEESFSPSSPYIQEERRQREAAQAVEAVARDADRNAYSHEHVQSLKEKLLRTIQTNEILRKRSRELSKKNRELRQHLLGDPAALPLPSFPSSSLLSSLSLAHSDRCRDMPQRLPSPPREDLKSSDSGVSSGALAGESDRRYSCPRETSSPSCGGRGGRRHPVFCRELSRNGNSRLDAQSGPQCRDFSPQLWRGERGNAGEMRPRESRESFGSCREVDDDSPQRWTRDGDREERRRARLPPSSSSPRHAGQAVDQRRLNYPQSFGASELRLCSSTPSFDEGGFPCSSTPSFDDEAILPCGREELQDSVGDNRGHLWGKRGRGREDPSWEATARTSGASPAYEEGWFRQEAFEEREEERRRQQFSPGCSPRSPTFLPCGGGTLRDAVEAPQPSKAACDGGYAGTVWSLPCVPDKAEVDNERREWKQATCEREPAEGDKTKCDKDAEGSERNCEGEREEKRRVKGLSEEVASVEGDFWAPASIIPSPLPSPAFAATGEKRLGDTVAPGVSSQAAFSLSCLSSARCASNPLPLTLDEAAGKVAAVESRSPPSVSPPPSTVSLLSSPEKARQGSDEGEETREAEQKREPREAIFPSPSLFSPAASFSSDASSSPCLAALRAVSPPGSRAKRLGEGAPEQVFLKEGETVNAGRHVLPQSLDAETGGFSNSAPVRERPRSLDLGKRNLHLAHEEDALAIHDQTSRTGSENEDSRDAAEDEAGVYAMPKAFEACGRAADGNGSSQTSCASLPKARDGESQEARPSLIVSTCEESPFCLCRKPPASLFEDPGSQKEAEKPLGKGEDGGVERGGEADRGAELELEEESSRVRQEAGEKANRDCNAKLRREQRGEGEIREETHEEKRTKAEAAEEETGGERREEETLKGDQEFRCERRDQSTGEQAAEERKTTGTKARCLADVLSRNINPLFPAEAVPGEEEDQDAGIFAEETNAAGCAKSERNEVDDAQFGSPRETGDSQTVCFSPHSALRCLSIKRLSLPLPSRSCKTFAEKLLSPSHVRSSLSSALAGSDSSSPGALGVSENVNAESRSPSYASTCWSSFLEDGERTEEARGCSRPSQPGVCTPSFQPSSLPPSFFTELPTTHMIQTARTNFPSTPLSFRSSSSSSPILGDLSRKSSSSRCSCGSSSPSPARGTAPRRPPVSSLRLSLPRAVASAQPSFCCNSSRSSSSLSSFSLSSSRPFLSARPPWGSTLGLKSKTRVGRQPRGYPAYLFHLHEAGKTICRRCDACPFRLLQREQEELRRLQALLLARKNRERSETREDVKPVQRESPSFLLKHSEERKDVLPGRTENDGQGPSLTSTRLRLGLLCQPMATALRQNEFRRENMDLCPRSPSPRGASSSVSPASSASPASSASPASSASRTSRTSRASRTSSPRSSVSHVSSARQGEAVRDVTESSDLRRLRPFESLRTLEKLRPLETRSVSSRALPLTPRVQTKSLTSRSASMAPVSSRAVSTSRGPRASLNSLSSMWTSQLVSAHHMKSRRLPDVDSCLARFPWFSAEDARLLACLLQQRRRELWEEIFNYERDLALAAAAPSQKRAAAPEDRREDGDTHRPGSLTETTEREGKEQERKAETDREEQERKTETDREEQERKTETDREEQKRKTETDREEHERKTETDREEQGRKAETDREEQERKTETDREEQERKAETERLQDWRETRKSEKTAKGSEQKSSRQRKLKTDAKDPRAGREEDTEKGKEGRKENARCRLVMRESGNLYGGSSCADLLLSPPGEDGGSSGCDRNGGESHESREEKKSRPPWRRPPSLVPRLCKGAWCGASKAAAALRHAEMNTR", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more TNFR/NGFR_Cys_rich_reg that are essential for its biological function; 2. The protein should belong to RSBN1/Dpy-21 that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MSSSASSRSVESSPARSSAASSSSSSEQHVAGGRLSSSQVNSTSVSSQSSSSRRARDDWCQSSHSSSSGSASSDSSSFCRGSRDSSSASVSRGTWRVDRDSFSVSGTSRSRLLSFPGSSHQPNRTENASHPDDLSSFRDSCVRRDTDTAERVATVRVNFPSRQNNDSSSGTCTSPISSSCDYSATESHSSASPSLRPSSGVVSSSRSSSRPGAALPLSVSSSSLLSQKKGRRKEAESLVDSSSTHSKQRDSAACRLLRVSPSASETTSVCRMSSGSGTARVARLEHQVEASFNPEEYPECFVCHPSLVAPSRLRETGKAQRDQRGLYTRFGRLHLSPQRLSVEATCVYGHCSSPPLSHLGAGAENSEGTNDLALSNEDKKGETQNARKRSASAFSESVSFREDTRRGSLLSVSLPAASSVLGSDLLSPSLREVYRHRGDSYLSRFKGGSSLLPAPRRSSCCVSSVPPFPESEKRNAGSDRRPTRSASLSSLLPNQPPASSSRRPSCSFSLLPAPLFSFGRRDPGGFDTDDACLRHDKESGVCTPAGTDLFVDVSREIRIIDALSEIQKESLIAAHCLDHSAALSEASAPLDASPSSSTVPHVSPSSVSSSLGRLHSSEKQTDCLRLRGSRGLQRRQRHTCSVAPSSADPLAPSFLQPHPSSKQLNQLLDHWRSGRVSVPRGSRVETRGEASCHAFDASPSCPPCSSQSLGSAAPNNACSRAAYGARLEAQANVLSNLDSRQGGRKEEEAADGGEDGEEGSRRLSQQTRPEGVEDRRGWTAIEEFNDCDGNVPRRSQLADFLRTCHVSRSQVGSVLGTHAKESSQDGEGEDQTGEDKGDAGDRCVTHEDDGGILCRSLESRKSEAKGYAMRKGSQKERVEKERMEGSPAKRRGPFPGGGETWTLPAYEADGLSSPRGREVVASCSSAGRLETSSKDASLSCSAFAGSENERLRAWALQAPSAEAFDRVDLVVRRLGLPQKTLQEKQTRPGDPGRSLLDEKPTVSEEKTKDRGGVAVPALASAAVKPFGNNEGGDGSAWSRLTNDLEAFRWKQMMQPSSTFLSAPVAKRGRALSPQGGADSEGRGESEEGRRGGCAAARRRAGAEEETRELLEAYEAARVKILAKSDEEAMQAAVSNSLHQSERVLGKLENVTRRLLEATCQSPKTKPISCSSSSAPSSSSSSSFSSSSSSSDCFSGDGASEATTVAPNGSAALSPPDGEKQRPSVGQRDALQAKLWESERELNSKDAEIGRTLQAVADSQAELARCRQELQESRSKALEAAKKAAVAQRMVRLLHQRRQEDRERWRQAVEECYRSRRSDQEADEDKQETDSASKKTDGNRNTESSLSRTSSCSSCSSSCSSFSSGSSSCSSSCSSCSSSCSSSCSSCSSSCSSSCSSSSSCSASCCGSTLLASASRPSSLSSAWFPAEDELPEVEELVAEYEAETRGYESRIAELQTLLEARNSAVEQLEVKGEALRNEVAFLQSMTEELRRARDAEEDCVLGALRQQVEEAEQSTLRLGREKDQLRSELDRVRASFTKQLAALETLNCRLRKEKEIFAEREKSQRRLHQEEHERMTRELHALRSEKEAGEAELLVLATAKAAAEMKCQQLEQQQETLKIHQERLCGNLLHLKNKAHGLSLSRRNHVSRQDSTNQAPSAECVDASSRRRVTSSVSEDDPSSALWSSSAERTDTSGNLFSSLSGPRSRSSGSPGESFERSHSSSCLASSPSCPSAASGSKEETSGSLQRMRSSASGSSKSVSVSSVNVLTYSEGPPLQSRSEFASSRPSFPSPSSASLSSESHRACGAPQAKEAANFFERLSSRLQSMREESERRQHALPGLPPHARSLEATQRQGRDSELGSFGEGPQGRAHSRQSGGDSAPSSFPAVPSQSGSSSASRGTEAFLGLAGDLERKDENASRFLSDSLGAQGQAQTDRGPMGFTARDEAGHLQGLPSGENDESITSSAFFARARQMKNSGKAVHSPDPRKDSGSESSDSQDPSAEEEEGDERAEEEEGDERAEDEEEDEREEEEEEEDEREEEEEEEDEREEEEEEGDERAEDEEEDEREEEEEEDERVEEEEEEDEREEEESVRGEGESGSGSISSSRRSRRSTPERGTRISSFSPRNGAGRKTSRSSFSGESRTSSEGSRRSGTSRSRDYASSPTSSRRDGETSPPGKSGHRRKRSNSASSEDSSRSAPQSDVSVNQVYAHPAALGSKTSGVRTPQASASRGAPASTAGATGGRPVSGSHPSRATERRDDGRQAKSVKKKEPQTRVRSRPRPESQESKTPESADSGATLDRGARHRETPRRNSESEEARPGEGERTCVSPASGGEKRRNFVSRDETSMGASRADHQETMKNAKLSTISRKRTPSPVAIYRVSPSSSSNASASQRESRAAKSSNTGMSSSSSFSLYRPHDFSREGSQGGPPPDFKFSEASSSSSSSISSSHSSSVPFPFSALASGSSSSAPAKTEKKVECEGAASSLSSLGASSSCHERVDPELRQQRGNTAEAQQKSDPSTVSPRKHSDEQRTEREGKTRRPEDSGCATQHRNPETRGRPPQPSLVAIQEGHPTSPFSVLPQHPPAARQLQPLSPSLRLSPSSVRCKQCAGVSSRFPHAHDLRVEPCCHRRCEGRNCSSGEESGEREQAVRCRHNPIPGRGPPVTENTVCHAPSDQGRTLAGGPRLAGSRHKEPENLSSASSCPSSSCPRAARQREGEGEKRHRETPSVKREENRKSSRTGEASSSVSIPNERSSDDVSPSGLERLSFGCTYTRYGREGREEKSPLLAPGHAANQRLTDGRSLHSFPDERKPSDMERRVASHMLPEKRTEEASPAAASGPGQRRLCGEACRPETGDKCGERQPVSSFSREKGTSSVQARRDESDEPRFVEKLRIGEQNPSLVLREMEDLRVTSRTAAEIDACMRHARLACRRAEPVSACPPSPFSFRGSVGDQLSPCESPHGPSHGASVSCVSAPTAIPPACCWLPEETAARGHRGNCVHANWQALADEELLEEEDGDTRRGEGEEREAREFGDRGERDDGHRAARGEVGCGVLGGRRERREETGRRRDTTRIPESCGGGEESFSPSSPYIQEERRQREAAQAVEAVARDADRNAYSHEHVQSLKEKLLRTIQTNEILRKRSRELSKKNRELRQHLLGDPAALPLPSFPSSSLLSSLSLAHSDRCRDMPQRLPSPPREDLKSSDSGVSSGALAGESDRRYSCPRETSSPSCGGRGGRRHPVFCRELSRNGNSRLDAQSGPQCRDFSPQLWRGERGNAGEMRPRESRESFGSCREVDDDSPQRWTRDGDREERRRARLPPSSSSPRHAGQAVDQRRLNYPQSFGASELRLCSSTPSFDEGGFPCSSTPSFDDEAILPCGREELQDSVGDNRGHLWGKRGRGREDPSWEATARTSGASPAYEEGWFRQEAFEEREEERRRQQFSPGCSPRSPTFLPCGGGTLRDAVEAPQPSKAACDGGYAGTVWSLPCVPDKAEVDNERREWKQATCEREPAEGDKTKCDKDAEGSERNCEGEREEKRRVKGLSEEVASVEGDFWAPASIIPSPLPSPAFAATGEKRLGDTVAPGVSSQAAFSLSCLSSARCASNPLPLTLDEAAGKVAAVESRSPPSVSPPPSTVSLLSSPEKARQGSDEGEETREAEQKREPREAIFPSPSLFSPAASFSSDASSSPCLAALRAVSPPGSRAKRLGEGAPEQVFLKEGETVNAGRHVLPQSLDAETGGFSNSAPVRERPRSLDLGKRNLHLAHEEDALAIHDQTSRTGSENEDSRDAAEDEAGVYAMPKAFEACGRAADGNGSSQTSCASLPKARDGESQEARPSLIVSTCEESPFCLCRKPPASLFEDPGSQKEAEKPLGKGEDGGVERGGEADRGAELELEEESSRVRQEAGEKANRDCNAKLRREQRGEGEIREETHEEKRTKAEAAEEETGGERREEETLKGDQEFRCERRDQSTGEQAAEERKTTGTKARCLADVLSRNINPLFPAEAVPGEEEDQDAGIFAEETNAAGCAKSERNEVDDAQFGSPRETGDSQTVCFSPHSALRCLSIKRLSLPLPSRSCKTFAEKLLSPSHVRSSLSSALAGSDSSSPGALGVSENVNAESRSPSYASTCWSSFLEDGERTEEARGCSRPSQPGVCTPSFQPSSLPPSFFTELPTTHMIQTARTNFPSTPLSFRSSSSSSPILGDLSRKSSSSRCSCGSSSPSPARGTAPRRPPVSSLRLSLPRAVASAQPSFCCNSSRSSSSLSSFSLSSSRPFLSARPPWGSTLGLKSKTRVGRQPRGYPAYLFHLHEAGKTICRRCDACPFRLLQREQEELRRLQALLLARKNRERSETREDVKPVQRESPSFLLKHSEERKDVLPGRTENDGQGPSLTSTRLRLGLLCQPMATALRQNEFRRENMDLCPRSPSPRGASSSVSPASSASPASSASPASSASRTSRTSRASRTSSPRSSVSHVSSARQGEAVRDVTESSDLRRLRPFESLRTLEKLRPLETRSVSSRALPLTPRVQTKSLTSRSASMAPVSSRAVSTSRGPRASLNSLSSMWTSQLVSAHHMKSRRLPDVDSCLARFPWFSAEDARLLACLLQQRRRELWEEIFNYERDLALAAAAPSQKRAAAPEDRREDGDTHRPGSLTETTEREGKEQERKAETDREEQERKTETDREEQERKTETDREEQKRKTETDREEHERKTETDREEQGRKAETDREEQERKTETDREEQERKAETERLQDWRETRKSEKTAKGSEQKSSRQRKLKTDAKDPRAGREEDTEKGKEGRKENARCRLVMRESGNLYGGSSCADLLLSPPGEDGGSSGCDRNGGESHESREEKKSRPPWRRPPSLVPRLCKGAWCGASKAAAALRHAEMNTR" }, { "InterPro": [ { "InterPro-ID": "IPR038275", "InterPro-Name": "Nuf2_N_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 39, "End": 204 }, { "InterPro-ID": "IPR005549", "InterPro-Name": "Kinetochore_Nuf2_N", "InterPro-Type": "DOMAIN", "Beg": 40, "End": 182 } ], "response#1": "MAAPGLPQPGSLSTLAGYPSSTYSSQNSPFFPSADRGGRMTLEEIKRDFTKHKLECPDTMWREPQPEQVQGLYSFAIESIFGLTVNDVRIEEVTGDVRSCLPSIDSLQFLSQDGRLHAKAIGNLRFIRLCQRLNRVLGLPEFSRETFASPTASGVQRFASAVCMLLRLRESLCRQFESQIQQRASLQQSLQKLSQNAQLVEQELLRFRAERQTQQPLAQRQKQQQSELEEELRQRHSELGALMEEFKERQAVHGRLELELGDLVLELMNLKQEREELHDQVVHSPEKLMERRDELRVQQKHLDAQLQELENLAASQQKLLLAFAKAVKKAKKAMEILSAHRDQVLAPHLGFRSDMRTREKLFRELGEQKEQLSKAVQDLQAEREELARQLEDQERKKDEEETELRGHLARAKREVEERKKALADQQDMTAAFLREAEKLEEKLAEQKQRHKLLVDAIEEEIQKVYAAFLTYVSQMQFIRSQMPLSLDLSQSASFLAEHSEKTHRGSPLACEREENDDFLASLLAESSPSSLGEEKENLPQSRPTAAADAERRLADFSPEKGRKRLSCLDEETEEEARMHERERESDRLFPAAREPREDGDFPMYGHAE", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Kinetochore_Nuf2_N that are essential for its biological function; 2. The protein should be classified within Nuf2_N_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MAAPGLPQPGSLSTLAGYPSSTYSSQNSPFFPSADRGGRMTLEEIKRDFTKHKLECPDTMWREPQPEQVQGLYSFAIESIFGLTVNDVRIEEVTGDVRSCLPSIDSLQFLSQDGRLHAKAIGNLRFIRLCQRLNRVLGLPEFSRETFASPTASGVQRFASAVCMLLRLRESLCRQFESQIQQRASLQQSLQKLSQNAQLVEQELLRFRAERQTQQPLAQRQKQQQSELEEELRQRHSELGALMEEFKERQAVHGRLELELGDLVLELMNLKQEREELHDQVVHSPEKLMERRDELRVQQKHLDAQLQELENLAASQQKLLLAFAKAVKKAKKAMEILSAHRDQVLAPHLGFRSDMRTREKLFRELGEQKEQLSKAVQDLQAEREELARQLEDQERKKDEEETELRGHLARAKREVEERKKALADQQDMTAAFLREAEKLEEKLAEQKQRHKLLVDAIEEEIQKVYAAFLTYVSQMQFIRSQMPLSLDLSQSASFLAEHSEKTHRGSPLACEREENDDFLASLLAESSPSSLGEEKENLPQSRPTAAADAERRLADFSPEKGRKRLSCLDEETEEEARMHERERESDRLFPAAREPREDGDFPMYGHAE" }, { "InterPro": [ { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 35, "End": 112 }, { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 35, "End": 109 } ], "response#1": "MLFKQAILVATTLTDLAVATPVVDVRRRTDPASSCSTGTLNCCNSSGTVEDKTIAGLLGILNIVVSDITALVGITCTPITVVGAGGTSCTSQTLCCDNNNFSGLITLGCIPININL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Hydrophobin, Hydrophobin that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MLFKQAILVATTLTDLAVATPVVDVRRRTDPASSCSTGTLNCCNSSGTVEDKTIAGLLGILNIVVSDITALVGITCTPITVVGAGGTSCTSQTLCCDNNNFSGLITLGCIPININL" }, { "InterPro": [ { "InterPro-ID": "IPR025723", "InterPro-Name": "Anion-transp_ATPase-like_dom", "InterPro-Type": "DOMAIN", "Beg": 20, "End": 285 }, { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 18, "End": 287 }, { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 6, "End": 381 }, { "InterPro-ID": "IPR016300", "InterPro-Name": "ATPase_ArsA/GET3", "InterPro-Type": "FAMILY", "Beg": 15, "End": 375 } ], "response#1": "MSVTPKTLDMGAILADTSNRVVVCCGAGGVGKTTTAAALALRAAEYGRTVVVLTIDPAKRLAQALGINDLGNTPQRVPLAPEVPGELHAMMLDMRRTFDEMVMQYSGPERAQSILDNQFYQTVATSLAGTQEYMAMEKLGQLLSQDRWDLIVVDTPPSRNALDFLDAPKRLGSFMDSRLWRLLLAPGRGIGRLITGVMGLAMKALSTVLGSQMLADAAAFVQSLDATFGGFREKADRTYALLKRRGTQFVVVSAAEPDALREASFFVDRLSQESMPLAGLVFNRTHPMLCALPIERAIDAAETLDAETTDSDATSLAAAVLRIHAERGQTAKREIRLLSRFTGANPTVPVVGVPSLPFDVSDLEALRALADQLTTVGNDAGRAAGR", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Anion-transp_ATPase-like_dom that are essential for its biological function; 2. The protein should belong to ATPase_ArsA/GET3 that shares evolutionary origin and functional similarity; 3. The protein should be classified within P-loop_NTPase, P-loop_NTPase sharing conserved structural features. The designed protein sequence is ", "reference": "MSVTPKTLDMGAILADTSNRVVVCCGAGGVGKTTTAAALALRAAEYGRTVVVLTIDPAKRLAQALGINDLGNTPQRVPLAPEVPGELHAMMLDMRRTFDEMVMQYSGPERAQSILDNQFYQTVATSLAGTQEYMAMEKLGQLLSQDRWDLIVVDTPPSRNALDFLDAPKRLGSFMDSRLWRLLLAPGRGIGRLITGVMGLAMKALSTVLGSQMLADAAAFVQSLDATFGGFREKADRTYALLKRRGTQFVVVSAAEPDALREASFFVDRLSQESMPLAGLVFNRTHPMLCALPIERAIDAAETLDAETTDSDATSLAAAVLRIHAERGQTAKREIRLLSRFTGANPTVPVVGVPSLPFDVSDLEALRALADQLTTVGNDAGRAAGR" }, { "InterPro": [ { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 39, "End": 128 }, { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 39, "End": 131 } ], "response#1": "MRFALAITTLIAAVTAAPSGHHGGKDLHKMTLGQAGDRCGADQSIYCCNEKTTKIEHSSPETGLGGLLGATVGADGLLSHLLGTCTKIPVNVLAVGNLLQSECTNRAACCHNTPSVAYGGLVNLALPCVAIGSLIQ", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Hydrophobin, Hydrophobin that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MRFALAITTLIAAVTAAPSGHHGGKDLHKMTLGQAGDRCGADQSIYCCNEKTTKIEHSSPETGLGGLLGATVGADGLLSHLLGTCTKIPVNVLAVGNLLQSECTNRAACCHNTPSVAYGGLVNLALPCVAIGSLIQ" }, { "InterPro": [ { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 33, "End": 112 }, { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 33, "End": 109 } ], "response#1": "MLATTIFATLLALAAAAPHGPSHGPSVKTGDICGNGNTMHCCNDESVTNKLTGPSVLSDLDLRKLLASECSPISVNVLLNQLVPIDNKCKQQSICCGEQKQNGLVNLGCTPITVLG", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Hydrophobin, Hydrophobin that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MLATTIFATLLALAAAAPHGPSHGPSVKTGDICGNGNTMHCCNDESVTNKLTGPSVLSDLDLRKLLASECSPISVNVLLNQLVPIDNKCKQQSICCGEQKQNGLVNLGCTPITVLG" }, { "InterPro": [ { "InterPro-ID": "IPR039460", "InterPro-Name": "SUPT7L", "InterPro-Type": "FAMILY", "Beg": 3, "End": 353 }, { "InterPro-ID": "IPR009072", "InterPro-Name": "Histone-fold", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 138, "End": 233 } ], "response#1": "MQTEHWGSLPAEDDGGQLTPDKYVPTAAKKLKLDEIRQRGDPQPQEKHHKLELRSALVTQTIEVMKQTEVLQSLIETYSNKNGSSNYLLNPCLMIPEVDFPPENAAELVGSQKFQKPIWFTPTVDTAYSRGDPEAYPEIPSSACRQAMRKVMCGMLRLAGFTDCSESAVQLLTDATEEFLRSFIGEYRGYYDSQPRLQNSTVLQLVPLERAHFAQTGTSLTQVHNYYKHKVLARNRAEIAEFNSVLQEYDKLMKESQSSMQKQHNEFNGHDFLNILDNSATGSSQSIGGMAMGDMLQDLGGSTGSSGTVSSQQMLYGLLDGQISSNTSNMTGTSGNGSTGGNGNGNGATISNFHATFET", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to SUPT7L that shares evolutionary origin and functional similarity; 2. The protein should be classified within Histone-fold sharing conserved structural features. The designed protein sequence is ", "reference": "MQTEHWGSLPAEDDGGQLTPDKYVPTAAKKLKLDEIRQRGDPQPQEKHHKLELRSALVTQTIEVMKQTEVLQSLIETYSNKNGSSNYLLNPCLMIPEVDFPPENAAELVGSQKFQKPIWFTPTVDTAYSRGDPEAYPEIPSSACRQAMRKVMCGMLRLAGFTDCSESAVQLLTDATEEFLRSFIGEYRGYYDSQPRLQNSTVLQLVPLERAHFAQTGTSLTQVHNYYKHKVLARNRAEIAEFNSVLQEYDKLMKESQSSMQKQHNEFNGHDFLNILDNSATGSSQSIGGMAMGDMLQDLGGSTGSSGTVSSQQMLYGLLDGQISSNTSNMTGTSGNGSTGGNGNGNGATISNFHATFET" }, { "InterPro": [ { "InterPro-ID": "IPR003021", "InterPro-Name": "Rad1_Rec1_Rad17", "InterPro-Type": "FAMILY", "Beg": 13, "End": 253 }, { "InterPro-ID": "IPR003011", "InterPro-Name": "Cell_cycle_checkpoint_Rad1", "InterPro-Type": "FAMILY", "Beg": 199, "End": 212 }, { "InterPro-ID": "IPR003011", "InterPro-Name": "Cell_cycle_checkpoint_Rad1", "InterPro-Type": "FAMILY", "Beg": 219, "End": 237 }, { "InterPro-ID": "IPR003011", "InterPro-Name": "Cell_cycle_checkpoint_Rad1", "InterPro-Type": "FAMILY", "Beg": 38, "End": 51 }, { "InterPro-ID": "IPR003011", "InterPro-Name": "Cell_cycle_checkpoint_Rad1", "InterPro-Type": "FAMILY", "Beg": 76, "End": 92 }, { "InterPro-ID": "IPR046938", "InterPro-Name": "DNA_clamp_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 20, "End": 135 }, { "InterPro-ID": "IPR003021", "InterPro-Name": "Rad1_Rec1_Rad17", "InterPro-Type": "FAMILY", "Beg": 12, "End": 271 }, { "InterPro-ID": "IPR003021", "InterPro-Name": "Rad1_Rec1_Rad17", "InterPro-Type": "FAMILY", "Beg": 219, "End": 236 }, { "InterPro-ID": "IPR003021", "InterPro-Name": "Rad1_Rec1_Rad17", "InterPro-Type": "FAMILY", "Beg": 121, "End": 141 }, { "InterPro-ID": "IPR003021", "InterPro-Name": "Rad1_Rec1_Rad17", "InterPro-Type": "FAMILY", "Beg": 58, "End": 74 }, { "InterPro-ID": "IPR003021", "InterPro-Name": "Rad1_Rec1_Rad17", "InterPro-Type": "FAMILY", "Beg": 236, "End": 253 }, { "InterPro-ID": "IPR003021", "InterPro-Name": "Rad1_Rec1_Rad17", "InterPro-Type": "FAMILY", "Beg": 16, "End": 33 }, { "InterPro-ID": "IPR003021", "InterPro-Name": "Rad1_Rec1_Rad17", "InterPro-Type": "FAMILY", "Beg": 41, "End": 58 } ], "response#1": "MTDVEPSPYGDCKFVARVEHIKTFIQAIKSICFNDYGMVQVSEDGLRITVEQGKSIQATLFMPPGAFMEFRVQDFQCFGVKMNVLSECLSLFGSADCSLRMMYRDKGDPLKIILYPHDDDDVSTECAIKTMDCDEPIDYDQNLKDPDLNVIFVRGPNLSKVFNELEKSAEEFEFVTSPNRPHFKITTVGIMQAVFSVEVAKTSPMMMMFNCKQTVVARYKSQQIRMTNKAMQSATKVAIKTNSVGLLELHLVMQGDSQEEIFIQFFIIPLLNTD", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Rad1_Rec1_Rad17, Cell_cycle_checkpoint_Rad1, Cell_cycle_checkpoint_Rad1, Cell_cycle_checkpoint_Rad1, Cell_cycle_checkpoint_Rad1, Rad1_Rec1_Rad17, Rad1_Rec1_Rad17, Rad1_Rec1_Rad17, Rad1_Rec1_Rad17, Rad1_Rec1_Rad17, Rad1_Rec1_Rad17, Rad1_Rec1_Rad17 that shares evolutionary origin and functional similarity; 2. The protein should be classified within DNA_clamp_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MTDVEPSPYGDCKFVARVEHIKTFIQAIKSICFNDYGMVQVSEDGLRITVEQGKSIQATLFMPPGAFMEFRVQDFQCFGVKMNVLSECLSLFGSADCSLRMMYRDKGDPLKIILYPHDDDDVSTECAIKTMDCDEPIDYDQNLKDPDLNVIFVRGPNLSKVFNELEKSAEEFEFVTSPNRPHFKITTVGIMQAVFSVEVAKTSPMMMMFNCKQTVVARYKSQQIRMTNKAMQSATKVAIKTNSVGLLELHLVMQGDSQEEIFIQFFIIPLLNTD" }, { "InterPro": [ { "InterPro-ID": "IPR011696", "InterPro-Name": "Huwentoxin-1", "InterPro-Type": "FAMILY", "Beg": 2, "End": 26 } ], "response#1": "YCQKFLWTCDSERPCCEGLVCRLWCKIN", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Huwentoxin-1 that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "YCQKFLWTCDSERPCCEGLVCRLWCKIN" }, { "InterPro": [ { "InterPro-ID": "IPR009003", "InterPro-Name": "Peptidase_S1_PA", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 1, "End": 192 }, { "InterPro-ID": "IPR001254", "InterPro-Name": "Trypsin_dom", "InterPro-Type": "DOMAIN", "Beg": 1, "End": 180 }, { "InterPro-ID": "IPR043504", "InterPro-Name": "Peptidase_S1_PA_chymotrypsin", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 50, "End": 187 }, { "InterPro-ID": "IPR001254", "InterPro-Name": "Trypsin_dom", "InterPro-Type": "DOMAIN", "Beg": 1, "End": 183 }, { "InterPro-ID": "IPR001254", "InterPro-Name": "Trypsin_dom", "InterPro-Type": "DOMAIN", "Beg": 36, "End": 185 }, { "InterPro-ID": "IPR033116", "InterPro-Name": "TRYPSIN_SER", "InterPro-Type": "ACTIVE_SITE", "Beg": 134, "End": 145 }, { "InterPro-ID": "IPR001254", "InterPro-Name": "Trypsin_dom", "InterPro-Type": "DOMAIN", "Beg": 56, "End": 180 } ], "response#1": "VVGGDECNINEHRSLVAIFVSTGFFCSGTLINQEVLNQEDKFICPNXKKNNEVLDVTNSENIVPLSLPSSPPSVGSVCRIMGWGTITPEKKTYPNVPHCANINLLDDAECHVGYERQGKEYRTLCAGVVQGGKDTCQGDSGGPLICNGQFQGIVSWGPHPCGHPGEPGVYTKVFDYTEWIQSIIAGNTAATCPP", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Trypsin_dom, Trypsin_dom, Trypsin_dom, Trypsin_dom that are essential for its biological function; 2. The protein should be classified within Peptidase_S1_PA, Peptidase_S1_PA_chymotrypsin sharing conserved structural features; 3. The protein must have TRYPSIN_SER that is conserved among related catalytic enzymes. The designed protein sequence is ", "reference": "VVGGDECNINEHRSLVAIFVSTGFFCSGTLINQEVLNQEDKFICPNXKKNNEVLDVTNSENIVPLSLPSSPPSVGSVCRIMGWGTITPEKKTYPNVPHCANINLLDDAECHVGYERQGKEYRTLCAGVVQGGKDTCQGDSGGPLICNGQFQGIVSWGPHPCGHPGEPGVYTKVFDYTEWIQSIIAGNTAATCPP" }, { "InterPro": [ { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 53, "End": 122 }, { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 53, "End": 125 } ], "response#1": "MLSLLSKAVSLAILVTAVVASPAGNGVEWSGGGTTTVTVTASSPTTTVTQSQCSTGDQKCCQSVQNSSAAGVSSLLGLLGIVLSGTDVPVGLTCLPIVGGACQSQAVCCTDNSYGNLISLGCSPLQL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Hydrophobin, Hydrophobin that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MLSLLSKAVSLAILVTAVVASPAGNGVEWSGGGTTTVTVTASSPTTTVTQSQCSTGDQKCCQSVQNSSAAGVSSLLGLLGIVLSGTDVPVGLTCLPIVGGACQSQAVCCTDNSYGNLISLGCSPLQL" }, { "InterPro": [ { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 30, "End": 104 }, { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 30, "End": 107 } ], "response#1": "MQFKLAFVSIALATLAVATPAPRGEPASSCSTGDLQCCNTVEPASSPSASTILGLLGIVIQGVDVLVGLTCSPITVIGLESGGCSAQAVCCTDNSNGGLISIGCLPVTL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Hydrophobin, Hydrophobin that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MQFKLAFVSIALATLAVATPAPRGEPASSCSTGDLQCCNTVEPASSPSASTILGLLGIVIQGVDVLVGLTCSPITVIGLESGGCSAQAVCCTDNSNGGLISIGCLPVTL" }, { "InterPro": [ { "InterPro-ID": "IPR001753", "InterPro-Name": "Enoyl-CoA_hydra/iso", "InterPro-Type": "FAMILY", "Beg": 11, "End": 197 }, { "InterPro-ID": "IPR051053", "InterPro-Name": "ECH/Chromodomain_protein", "InterPro-Type": "FAMILY", "Beg": 7, "End": 279 }, { "InterPro-ID": "IPR029045", "InterPro-Name": "ClpP/crotonase-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 5, "End": 264 } ], "response#1": "MSGVTTVEYRGRVAVITICNERKLNALDLHGYYELSERMREVATHDEVYVTLLTAKGRFFSAGADVSTIRDPPTTGEDDSGIADGGRRQWLQSFVAFNLNITQAFYSHPKILVVGLNGPVVGLSAALVSFADFIYATPSTFLLTPFSSLGLVAEGGASRALVQRLGVSKANEALLMSRRVPADELLQTGFVNKVFTELKGAKDDDVRFKELVLAEIDDKLGDHLVGDSLIGIKELIRRPEIDVLEGQNAREVFAGLGRFMSGVPQREFLKLASGEKRHKL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Enoyl-CoA_hydra/iso, ECH/Chromodomain_protein that shares evolutionary origin and functional similarity; 2. The protein should be classified within ClpP/crotonase-like_dom_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MSGVTTVEYRGRVAVITICNERKLNALDLHGYYELSERMREVATHDEVYVTLLTAKGRFFSAGADVSTIRDPPTTGEDDSGIADGGRRQWLQSFVAFNLNITQAFYSHPKILVVGLNGPVVGLSAALVSFADFIYATPSTFLLTPFSSLGLVAEGGASRALVQRLGVSKANEALLMSRRVPADELLQTGFVNKVFTELKGAKDDDVRFKELVLAEIDDKLGDHLVGDSLIGIKELIRRPEIDVLEGQNAREVFAGLGRFMSGVPQREFLKLASGEKRHKL" }, { "InterPro": [ { "InterPro-ID": "IPR001138", "InterPro-Name": "Zn2Cys6_DnaBD", "InterPro-Type": "DOMAIN", "Beg": 172, "End": 207 }, { "InterPro-ID": "IPR001138", "InterPro-Name": "Zn2Cys6_DnaBD", "InterPro-Type": "DOMAIN", "Beg": 176, "End": 212 }, { "InterPro-ID": "IPR036864", "InterPro-Name": "Zn2-C6_fun-type_DNA-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 175, "End": 258 }, { "InterPro-ID": "IPR036864", "InterPro-Name": "Zn2-C6_fun-type_DNA-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 167, "End": 212 }, { "InterPro-ID": "IPR001138", "InterPro-Name": "Zn2Cys6_DnaBD", "InterPro-Type": "DOMAIN", "Beg": 171, "End": 215 }, { "InterPro-ID": "IPR050815", "InterPro-Name": "TF_fung", "InterPro-Type": "FAMILY", "Beg": 120, "End": 866 }, { "InterPro-ID": "IPR001138", "InterPro-Name": "Zn2Cys6_DnaBD", "InterPro-Type": "DOMAIN", "Beg": 176, "End": 206 }, { "InterPro-ID": "IPR007219", "InterPro-Name": "Transcription_factor_dom_fun", "InterPro-Type": "DOMAIN", "Beg": 432, "End": 514 }, { "InterPro-ID": "IPR001138", "InterPro-Name": "Zn2Cys6_DnaBD", "InterPro-Type": "DOMAIN", "Beg": 176, "End": 204 }, { "InterPro-ID": "IPR007219", "InterPro-Name": "Transcription_factor_dom_fun", "InterPro-Type": "DOMAIN", "Beg": 331, "End": 579 } ], "response#1": "MSGRAVLSPQHAQASFDSGLQLYGDVPELNAVPPPSHSALMDFTRFDDFAFAYYGLPDQSSLVSLVDHTHTFQSLTTFPQHQAISGLAHSGLPFGTLPTDNYNQSMEDSKAPPDRTSPASNALEDPTTDEFGLASPNRAGGTDLGGKPKEDKADATPAWSELKTKAGKERKRLPLACIACRRKKIRCSGEKPACKQCLHSCIPCVYKVATRKAAPRTNCMAMLDKRPKRMEERAIKAISKSDQEVASSVTHPVVKQAIPGTVTSSRPTKKRGAEEAFEPDLEAWAKASSEPKIEGDDGSSSLQVQEGEENKLQHEGTEALPSREIQEHLAEVFFENIYGQSYHLLHKPSYMRKLKNGTLPPVLVLTVCAVAARFTSNPLVSSSGPEFLRGEEWASHARDICTRRYEWPNLTILTCLLILGLHEFGTCQGGRSWALGGQAIRMAFALQLHKDLEYDPSGRNGTTTQLSFIDREIRRRIMWACFLMDRFNSSGTDRPMFIREDTIQIPLPVKEKYFQFDMPAPTEMLDGRVPHPPSPNDGQIANSRENMGVAAFLIRAIALWGRIITYLSQGCKDLDPNPLWEDESHYMKHLDDVVNLEASLPLSLKHSAENLEVHKTENTASQFLFMHICLQHNILFVNRAAMSARKQHGVHDDFVSEASKRAFNAANRISELLREAEQSGCFVSAPFAGYCAFSSTTVHILGIISRNPFTKLAAQANLTTNIKYLHRMKKYWGMFHWMVENVRTQYRNVLDAMRAGANVEERATQPSFLQYGDWFNRYPRGLSDAEFMDPATHKRKDSGADGVLEAKRELRSVEEYFTLPTPRRVENKDTIRATAPKRKQSAKKQAGMPAQPGQHLDSLQSIDADAVSQERKFSGGLGLQITGAAGFNPLAASNQQSPDFSTTISPTRPANMTPFAHHAHTPTFFPPELLAMNFGQGSNGNIDPLDRQLIYGGYSMDASTGLGGGQDMMSGLGWDTVALGAQPDGRLQSRPSNAKAGMHGQSAGMADGAGLSRPEASSAWFMPFNMEPPDMDQDAGFNMGGIDPFTGVFGGGGSGLATPNALGGLILGHCRGSSTHSTR", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Zn2Cys6_DnaBD, Zn2Cys6_DnaBD, Zn2Cys6_DnaBD, Zn2Cys6_DnaBD, Transcription_factor_dom_fun, Zn2Cys6_DnaBD, Transcription_factor_dom_fun that are essential for its biological function; 2. The protein should belong to TF_fung that shares evolutionary origin and functional similarity; 3. The protein should be classified within Zn2-C6_fun-type_DNA-bd_sf, Zn2-C6_fun-type_DNA-bd_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MSGRAVLSPQHAQASFDSGLQLYGDVPELNAVPPPSHSALMDFTRFDDFAFAYYGLPDQSSLVSLVDHTHTFQSLTTFPQHQAISGLAHSGLPFGTLPTDNYNQSMEDSKAPPDRTSPASNALEDPTTDEFGLASPNRAGGTDLGGKPKEDKADATPAWSELKTKAGKERKRLPLACIACRRKKIRCSGEKPACKQCLHSCIPCVYKVATRKAAPRTNCMAMLDKRPKRMEERAIKAISKSDQEVASSVTHPVVKQAIPGTVTSSRPTKKRGAEEAFEPDLEAWAKASSEPKIEGDDGSSSLQVQEGEENKLQHEGTEALPSREIQEHLAEVFFENIYGQSYHLLHKPSYMRKLKNGTLPPVLVLTVCAVAARFTSNPLVSSSGPEFLRGEEWASHARDICTRRYEWPNLTILTCLLILGLHEFGTCQGGRSWALGGQAIRMAFALQLHKDLEYDPSGRNGTTTQLSFIDREIRRRIMWACFLMDRFNSSGTDRPMFIREDTIQIPLPVKEKYFQFDMPAPTEMLDGRVPHPPSPNDGQIANSRENMGVAAFLIRAIALWGRIITYLSQGCKDLDPNPLWEDESHYMKHLDDVVNLEASLPLSLKHSAENLEVHKTENTASQFLFMHICLQHNILFVNRAAMSARKQHGVHDDFVSEASKRAFNAANRISELLREAEQSGCFVSAPFAGYCAFSSTTVHILGIISRNPFTKLAAQANLTTNIKYLHRMKKYWGMFHWMVENVRTQYRNVLDAMRAGANVEERATQPSFLQYGDWFNRYPRGLSDAEFMDPATHKRKDSGADGVLEAKRELRSVEEYFTLPTPRRVENKDTIRATAPKRKQSAKKQAGMPAQPGQHLDSLQSIDADAVSQERKFSGGLGLQITGAAGFNPLAASNQQSPDFSTTISPTRPANMTPFAHHAHTPTFFPPELLAMNFGQGSNGNIDPLDRQLIYGGYSMDASTGLGGGQDMMSGLGWDTVALGAQPDGRLQSRPSNAKAGMHGQSAGMADGAGLSRPEASSAWFMPFNMEPPDMDQDAGFNMGGIDPFTGVFGGGGSGLATPNALGGLILGHCRGSSTHSTR" }, { "InterPro": [ { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 34, "End": 114 }, { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 39, "End": 117 } ], "response#1": "MRLSISKLSVVMLALPILASASVLPRTGSTGASCGSTTSGQAQCCNSTQSNTTPLPFPLSVITGLLGIDLGAITGLVGLTCNPITVLGLGGTNCNSQAVCCTGNTFNGLINLGCSPLNVAL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Hydrophobin, Hydrophobin that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MRLSISKLSVVMLALPILASASVLPRTGSTGASCGSTTSGQAQCCNSTQSNTTPLPFPLSVITGLLGIDLGAITGLVGLTCNPITVLGLGGTNCNSQAVCCTGNTFNGLINLGCSPLNVAL" }, { "InterPro": [ { "InterPro-ID": "IPR003103", "InterPro-Name": "BAG_domain", "InterPro-Type": "DOMAIN", "Beg": 75, "End": 152 }, { "InterPro-ID": "IPR036533", "InterPro-Name": "BAG_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 69, "End": 152 }, { "InterPro-ID": "IPR003103", "InterPro-Name": "BAG_domain", "InterPro-Type": "DOMAIN", "Beg": 81, "End": 150 }, { "InterPro-ID": "IPR040400", "InterPro-Name": "BAG5/6/7/8", "InterPro-Type": "FAMILY", "Beg": 52, "End": 152 }, { "InterPro-ID": "IPR000048", "InterPro-Name": "IQ_motif_EF-hand-BS", "InterPro-Type": "BINDING_SITE", "Beg": 55, "End": 72 } ], "response#1": "MGSYHYTSTSHFFFAGGGEGEYSSYKGTGSTDTHRPTTVRIPVTTPGPERPPDDAAAARIQAAFRGHLVRRHAAAVRGADDEATRLERLLRRQETVDAVRGDERERARFSEALMAVLLRLDAVPGYYPAVREARRAVTRRVVGLQEVFDAVLAAPDAADTCGVPASLDQVLEGIWGESPAAPPPPPPPPPPAAVEVEEEVVRSPCWRRFFGGV", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more BAG_domain, BAG_domain that are essential for its biological function; 2. The protein should belong to BAG5/6/7/8 that shares evolutionary origin and functional similarity; 3. The protein should be classified within BAG_dom_sf sharing conserved structural features; 4. The protein should include a IQ_motif_EF-hand-BS that enables ligand binding under diverse conditions. The designed protein sequence is ", "reference": "MGSYHYTSTSHFFFAGGGEGEYSSYKGTGSTDTHRPTTVRIPVTTPGPERPPDDAAAARIQAAFRGHLVRRHAAAVRGADDEATRLERLLRRQETVDAVRGDERERARFSEALMAVLLRLDAVPGYYPAVREARRAVTRRVVGLQEVFDAVLAAPDAADTCGVPASLDQVLEGIWGESPAAPPPPPPPPPPAAVEVEEEVVRSPCWRRFFGGV" }, { "InterPro": [ { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 31, "End": 119 }, { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 31, "End": 122 } ], "response#1": "MMFSKPVVLATTALATFAAATPLVARTEPTCSSTEIKCCENVGTAAVVSSVLTPILVSIPLVGPLLSLLGLNAVVALLFGTVDVVLGLTCSGIDVGGSCNAQTVCCENVQFNGLINVGCVAIDIL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Hydrophobin, Hydrophobin that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MMFSKPVVLATTALATFAAATPLVARTEPTCSSTEIKCCENVGTAAVVSSVLTPILVSIPLVGPLLSLLGLNAVVALLFGTVDVVLGLTCSGIDVGGSCNAQTVCCENVQFNGLINVGCVAIDIL" }, { "InterPro": [ { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 33, "End": 109 }, { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 33, "End": 106 } ], "response#1": "MFSIRIATVVLAASALLAAASPITNTETPVNQCGSGSIQCCESVQSASAAQAAGILGPLDILTNLQGLVASHCSPLAAVGVSGTSCSSQTVCCKDVSKSGLVNLGCSPINLNL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Hydrophobin, Hydrophobin that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MFSIRIATVVLAASALLAAASPITNTETPVNQCGSGSIQCCESVQSASAAQAAGILGPLDILTNLQGLVASHCSPLAAVGVSGTSCSSQTVCCKDVSKSGLVNLGCSPINLNL" }, { "InterPro": [ { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 30, "End": 107 }, { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 30, "End": 104 } ], "response#1": "MYSQSMVLLAAAFASFVAASPMALHGANSCSTGPVHCCNSVEHHTQPHANSLARGSGLVGLDIETLVGNIGLDCSPIGLSSTDCTAQTVCCDDVTFDGKVAVGCTPVNLSVL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Hydrophobin, Hydrophobin that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MYSQSMVLLAAAFASFVAASPMALHGANSCSTGPVHCCNSVEHHTQPHANSLARGSGLVGLDIETLVGNIGLDCSPIGLSSTDCTAQTVCCDDVTFDGKVAVGCTPVNLSVL" }, { "InterPro": [ { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 60, "End": 159 }, { "InterPro-ID": "IPR019778", "InterPro-Name": "Hydrophobin_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 129, "End": 140 }, { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 60, "End": 157 } ], "response#1": "MRFSISALVLGLAATVYALPPGAPSAGGAGSGNGVGNKGNTDVRFSVPDNMTVKQAQAECGDQAQLSCCNKAVYAGDTTDINSGILGGTLSNLIGSGSGASGLGLFDQCSKLDLQIPVLIGIPIQDLINQKCKQNIACCQNSPSSANSDLIGLGLPCVALGSIL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Hydrophobin, Hydrophobin that shares evolutionary origin and functional similarity; 2. The protein should contain Hydrophobin_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MRFSISALVLGLAATVYALPPGAPSAGGAGSGNGVGNKGNTDVRFSVPDNMTVKQAQAECGDQAQLSCCNKAVYAGDTTDINSGILGGTLSNLIGSGSGASGLGLFDQCSKLDLQIPVLIGIPIQDLINQKCKQNIACCQNSPSSANSDLIGLGLPCVALGSIL" }, { "InterPro": [ { "InterPro-ID": "IPR020400", "InterPro-Name": "Cecropin_insect", "InterPro-Type": "FAMILY", "Beg": 1, "End": 62 }, { "InterPro-ID": "IPR000875", "InterPro-Name": "Cecropin", "InterPro-Type": "FAMILY", "Beg": 32, "End": 61 } ], "response#1": "MNFNRLFILVLVAVLVVLGQQQCGVEAAPRWKFGKKLEKVGKNVFNAAKKALPVVAGYKALG", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Cecropin_insect, Cecropin that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MNFNRLFILVLVAVLVVLGQQQCGVEAAPRWKFGKKLEKVGKNVFNAAKKALPVVAGYKALG" }, { "InterPro": [ { "InterPro-ID": "IPR000875", "InterPro-Name": "Cecropin", "InterPro-Type": "FAMILY", "Beg": 28, "End": 56 }, { "InterPro-ID": "IPR020400", "InterPro-Name": "Cecropin_insect", "InterPro-Type": "FAMILY", "Beg": 1, "End": 58 } ], "response#1": "MNFTKLFAIVLLAALVLLGQTEAGGLKKLGKKLEGAGKRVFKASEKALPVVVGIKAIGK", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Cecropin, Cecropin_insect that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MNFTKLFAIVLLAALVLLGQTEAGGLKKLGKKLEGAGKRVFKASEKALPVVVGIKAIGK" }, { "InterPro": [ { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 35, "End": 109 }, { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 35, "End": 112 } ], "response#1": "MLFKQAILVATTLTTLAVATPVVDVRRRTDPASSCSTGTLNCCNSSGTVEDKTIAGLLGILNIVVSDITALVGITCTPITVVGAGGTSCTSQTLCCDNNNFSGLITLGCIPININL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Hydrophobin, Hydrophobin that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MLFKQAILVATTLTTLAVATPVVDVRRRTDPASSCSTGTLNCCNSSGTVEDKTIAGLLGILNIVVSDITALVGITCTPITVVGAGGTSCTSQTLCCDNNNFSGLITLGCIPININL" }, { "InterPro": [ { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 58, "End": 132 }, { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 58, "End": 129 } ], "response#1": "MKFTSVIALVATAATLVGAVPFETNAERLARGLPPLPPARRASGVEAAKPKPSPSHGCSTGPVQCCNDLVDRSNHTVGILIGLLGIVLGPVTGLFGLGCSPLLGGGAKCQSQTVCCSDNKFSGIINIGCSPINIGL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Hydrophobin, Hydrophobin that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MKFTSVIALVATAATLVGAVPFETNAERLARGLPPLPPARRASGVEAAKPKPSPSHGCSTGPVQCCNDLVDRSNHTVGILIGLLGIVLGPVTGLFGLGCSPLLGGGAKCQSQTVCCSDNKFSGIINIGCSPINIGL" }, { "InterPro": [ { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 41, "End": 133 }, { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 41, "End": 134 } ], "response#1": "MKFFVPAFLFAATAMALPGSGSAAGVAPHSNNEVEDAVNKCGDGAHMSCCNKINKNEGISQNNIGVLSNVLGAIGSEGLGLGQGCTQLDIPISVLGAAGLTDFLKKNCQQNIACCQNSNSQANGNLVGVAAPCVSFGGLL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Hydrophobin, Hydrophobin that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MKFFVPAFLFAATAMALPGSGSAAGVAPHSNNEVEDAVNKCGDGAHMSCCNKINKNEGISQNNIGVLSNVLGAIGSEGLGLGQGCTQLDIPISVLGAAGLTDFLKKNCQQNIACCQNSNSQANGNLVGVAAPCVSFGGLL" }, { "InterPro": [ { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 38, "End": 107 } ], "response#1": "MRLSILSVFSLVGAGMVSALPQESNLSMKRSDTSECVGPLLCCGTLTTPLDPVVDPLLLALGIDAANIVGSIGLLCHGYEESSCPTKPQCCTEANLLGGTLALGCADLK", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Hydrophobin that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MRLSILSVFSLVGAGMVSALPQESNLSMKRSDTSECVGPLLCCGTLTTPLDPVVDPLLLALGIDAANIVGSIGLLCHGYEESSCPTKPQCCTEANLLGGTLALGCADLK" }, { "InterPro": [ { "InterPro-ID": "IPR020956", "InterPro-Name": "TF_Aft1_OSM", "InterPro-Type": "DOMAIN", "Beg": 24, "End": 76 }, { "InterPro-ID": "IPR046347", "InterPro-Name": "bZIP_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 349, "End": 409 }, { "InterPro-ID": "IPR004827", "InterPro-Name": "bZIP", "InterPro-Type": "DOMAIN", "Beg": 345, "End": 409 }, { "InterPro-ID": "IPR004827", "InterPro-Name": "bZIP", "InterPro-Type": "DOMAIN", "Beg": 349, "End": 405 }, { "InterPro-ID": "IPR051027", "InterPro-Name": "bZIP_transcription_factors", "InterPro-Type": "FAMILY", "Beg": 25, "End": 433 }, { "InterPro-ID": "IPR021756", "InterPro-Name": "TF_Aft1_HRR", "InterPro-Type": "DOMAIN", "Beg": 173, "End": 238 }, { "InterPro-ID": "IPR021755", "InterPro-Name": "TF_Aft1_HRA", "InterPro-Type": "DOMAIN", "Beg": 98, "End": 167 }, { "InterPro-ID": "IPR004827", "InterPro-Name": "bZIP", "InterPro-Type": "DOMAIN", "Beg": 347, "End": 410 } ], "response#1": "MKPPTRSQNRSDSQAASSQKDQKSNVENQTSLAPPPRPGAPTASDTPDYFNSMHNPFSLEPNPFEQSFGGNPADTPGKSLLPSVAALTSPALPGTSSASGYNWNNSLRSGPLSPAMLPGPTGPNDYFDSIGRGFPTPNESSLRTGLTPGGGGSMFPAPSPNSQALLQQLQNGGATPSTIDFHRTALAAKKNNSNAPTSNPNEQEQAAANMDVKPARPADFTQHDAADAANGLFMLAKGGQANNAPMNHAPMSNDTRAAARRVSQNTNGTSAEDASDHEPAKPAKGKGKKNTAKAPAANNRRKAEDAPKGSNKRSKSSMEMPSDMDDEDDEDDDMKQFPMDTKKMTDEEKRRNFLERNRVAALKCRQRKKQWLANLQNKVELFTSENDALTATVTQLREEIVNLKTLLLAHKDCPVSQAQGLGPLMMNGMSAGYDHHGYNMPPNMGMQPGGIPTQGMRR", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more TF_Aft1_OSM, bZIP, bZIP, TF_Aft1_HRR, TF_Aft1_HRA, bZIP that are essential for its biological function; 2. The protein should belong to bZIP_transcription_factors that shares evolutionary origin and functional similarity; 3. The protein should be classified within bZIP_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MKPPTRSQNRSDSQAASSQKDQKSNVENQTSLAPPPRPGAPTASDTPDYFNSMHNPFSLEPNPFEQSFGGNPADTPGKSLLPSVAALTSPALPGTSSASGYNWNNSLRSGPLSPAMLPGPTGPNDYFDSIGRGFPTPNESSLRTGLTPGGGGSMFPAPSPNSQALLQQLQNGGATPSTIDFHRTALAAKKNNSNAPTSNPNEQEQAAANMDVKPARPADFTQHDAADAANGLFMLAKGGQANNAPMNHAPMSNDTRAAARRVSQNTNGTSAEDASDHEPAKPAKGKGKKNTAKAPAANNRRKAEDAPKGSNKRSKSSMEMPSDMDDEDDEDDDMKQFPMDTKKMTDEEKRRNFLERNRVAALKCRQRKKQWLANLQNKVELFTSENDALTATVTQLREEIVNLKTLLLAHKDCPVSQAQGLGPLMMNGMSAGYDHHGYNMPPNMGMQPGGIPTQGMRR" }, { "InterPro": [ { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 52, "End": 151 }, { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 52, "End": 149 } ], "response#1": "MQFTLSAVVLALAGFSAALPAESMNNGLQHQNGTPRFPVPDSLTIEQAQAKCGDQAQLSCCNKATYAGDTTDINSGILGGTLSNLIGAGSGASGLGLFDQCSKLGAQIPIVIGIPIQDILNQQCKQNIACCANSPSTASGNLVGAALPCVALGSIL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Hydrophobin, Hydrophobin that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MQFTLSAVVLALAGFSAALPAESMNNGLQHQNGTPRFPVPDSLTIEQAQAKCGDQAQLSCCNKATYAGDTTDINSGILGGTLSNLIGAGSGASGLGLFDQCSKLGAQIPIVIGIPIQDILNQQCKQNIACCANSPSTASGNLVGAALPCVALGSIL" }, { "InterPro": [ { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 60, "End": 151 }, { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 60, "End": 145 } ], "response#1": "MQFSLSAIVLGLAATVYALPPSAPVAGGAGAGNGVGNKGNTDVRFSVPDNLTVKQAQAKCGDQAQLSCCNKAVYAGDTTDINSGILGGTLSNLIGSGSGASGLGLFDQCSKLDLQVPILALLPIQDLVNQKCKQNIACCQNSPSSAVSTPPIIDQKAQLTHHRTPTSLVLASPVLPLAPSSKRLAMFSRIMQAALVITPALWTLVQSSTYAEMWIVIDSEDGKQAFD", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Hydrophobin, Hydrophobin that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MQFSLSAIVLGLAATVYALPPSAPVAGGAGAGNGVGNKGNTDVRFSVPDNLTVKQAQAKCGDQAQLSCCNKAVYAGDTTDINSGILGGTLSNLIGSGSGASGLGLFDQCSKLDLQVPILALLPIQDLVNQKCKQNIACCQNSPSSAVSTPPIIDQKAQLTHHRTPTSLVLASPVLPLAPSSKRLAMFSRIMQAALVITPALWTLVQSSTYAEMWIVIDSEDGKQAFD" }, { "InterPro": [ { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 33, "End": 112 }, { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 33, "End": 115 } ], "response#1": "MQFKTIFATLAAFAAVASALPTSSSEQNGNGQCAVGQAQCCSQVQKQGKDASDALAGLGLAFNQILDGAIGLDCQQIPVGVLGGAIAIQNTCKNTAVCCQGSANNGLIQTSCTPLSIN", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Hydrophobin, Hydrophobin that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MQFKTIFATLAAFAAVASALPTSSSEQNGNGQCAVGQAQCCSQVQKQGKDASDALAGLGLAFNQILDGAIGLDCQQIPVGVLGGAIAIQNTCKNTAVCCQGSANNGLIQTSCTPLSIN" }, { "InterPro": [ { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 28, "End": 103 }, { "InterPro-ID": "IPR019778", "InterPro-Name": "Hydrophobin_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 80, "End": 91 }, { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 28, "End": 106 } ], "response#1": "MQFKFLTTVALATLAVAVPTDPPPTNQCNAPNNLECCNSVQAPTNSGLIGTLLGLLNISVGDITGLVGLTCNPISLIGGGNSCNAQTVCCQNNYFGGLISIGCTPIIIDV", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Hydrophobin, Hydrophobin that shares evolutionary origin and functional similarity; 2. The protein should contain Hydrophobin_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MQFKFLTTVALATLAVAVPTDPPPTNQCNAPNNLECCNSVQAPTNSGLIGTLLGLLNISVGDITGLVGLTCNPISLIGGGNSCNAQTVCCQNNYFGGLISIGCTPIIIDV" }, { "InterPro": [ { "InterPro-ID": "IPR019778", "InterPro-Name": "Hydrophobin_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 83, "End": 94 }, { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 32, "End": 106 }, { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 32, "End": 109 } ], "response#1": "MQFKFLSTVALATLAVAAPAPTDPTPIPPSQCNTGPIQCCNTVTQASNPVAGLLLGLLGIVLQDLNVLVGLTCSPISIIGLPGNSCNAQPVCCQNNNFNGLIAIGCTPININL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Hydrophobin, Hydrophobin that shares evolutionary origin and functional similarity; 2. The protein should contain Hydrophobin_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MQFKFLSTVALATLAVAAPAPTDPTPIPPSQCNTGPIQCCNTVTQASNPVAGLLLGLLGIVLQDLNVLVGLTCSPISIIGLPGNSCNAQPVCCQNNNFNGLIAIGCTPININL" }, { "InterPro": [ { "InterPro-ID": "IPR018208", "InterPro-Name": "GH11_AS_1", "InterPro-Type": "ACTIVE_SITE", "Beg": 112, "End": 122 }, { "InterPro-ID": "IPR000254", "InterPro-Name": "Cellulose-bd_dom_fun", "InterPro-Type": "DOMAIN", "Beg": 260, "End": 286 }, { "InterPro-ID": "IPR033123", "InterPro-Name": "GH11_dom", "InterPro-Type": "DOMAIN", "Beg": 31, "End": 219 }, { "InterPro-ID": "IPR033123", "InterPro-Name": "GH11_dom", "InterPro-Type": "DOMAIN", "Beg": 40, "End": 216 }, { "InterPro-ID": "IPR013320", "InterPro-Name": "ConA-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 31, "End": 218 }, { "InterPro-ID": "IPR001137", "InterPro-Name": "Glyco_hydro_11", "InterPro-Type": "FAMILY", "Beg": 188, "End": 196 }, { "InterPro-ID": "IPR001137", "InterPro-Name": "Glyco_hydro_11", "InterPro-Type": "FAMILY", "Beg": 140, "End": 146 }, { "InterPro-ID": "IPR001137", "InterPro-Name": "Glyco_hydro_11", "InterPro-Type": "FAMILY", "Beg": 165, "End": 174 }, { "InterPro-ID": "IPR001137", "InterPro-Name": "Glyco_hydro_11", "InterPro-Type": "FAMILY", "Beg": 112, "End": 122 }, { "InterPro-ID": "IPR001137", "InterPro-Name": "Glyco_hydro_11", "InterPro-Type": "FAMILY", "Beg": 160, "End": 165 }, { "InterPro-ID": "IPR001137", "InterPro-Name": "Glyco_hydro_11", "InterPro-Type": "FAMILY", "Beg": 102, "End": 111 }, { "InterPro-ID": "IPR000254", "InterPro-Name": "Cellulose-bd_dom_fun", "InterPro-Type": "DOMAIN", "Beg": 256, "End": 283 }, { "InterPro-ID": "IPR013319", "InterPro-Name": "GH11/12", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 31, "End": 221 }, { "InterPro-ID": "IPR035971", "InterPro-Name": "CBD_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 255, "End": 287 }, { "InterPro-ID": "IPR001137", "InterPro-Name": "Glyco_hydro_11", "InterPro-Type": "FAMILY", "Beg": 1, "End": 219 }, { "InterPro-ID": "IPR000254", "InterPro-Name": "Cellulose-bd_dom_fun", "InterPro-Type": "DOMAIN", "Beg": 255, "End": 287 }, { "InterPro-ID": "IPR033119", "InterPro-Name": "GH11_AS_2", "InterPro-Type": "ACTIVE_SITE", "Beg": 203, "End": 214 }, { "InterPro-ID": "IPR000254", "InterPro-Name": "Cellulose-bd_dom_fun", "InterPro-Type": "DOMAIN", "Beg": 252, "End": 287 } ], "response#1": "MVCFSSLFVAASAIAVVFASPVDHEQLAKRQSTPSSQGTHDGYFYSWWTDGGAAATYTNLAGGEYSVSWSNGGNLVGGKGWNPGSARTITYSGTYNPNGNSYLAVYGWTRNPLVEYYVVENFGTYNPSSGATARGQVTHDGALYRLFESTRTNQPSIDGTATFQQYWAVRDVKRTGGTVNMATFFNAWTSAGMRLGTHNYQVVATEGYFSSGSARINVAGGGGSTPSPPSTPSPPTTPSPPPVTPPPSGGGSCAARWGQCGGSGWNGATCCSAGTCQAQNQWYSQCL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Cellulose-bd_dom_fun, GH11_dom, GH11_dom, Cellulose-bd_dom_fun, Cellulose-bd_dom_fun, Cellulose-bd_dom_fun that are essential for its biological function; 2. The protein should belong to Glyco_hydro_11, Glyco_hydro_11, Glyco_hydro_11, Glyco_hydro_11, Glyco_hydro_11, Glyco_hydro_11, Glyco_hydro_11 that shares evolutionary origin and functional similarity; 3. The protein should be classified within ConA-like_dom_sf, GH11/12, CBD_sf sharing conserved structural features; 4. The protein must have GH11_AS_1, GH11_AS_2 that is conserved among related catalytic enzymes. The designed protein sequence is ", "reference": "MVCFSSLFVAASAIAVVFASPVDHEQLAKRQSTPSSQGTHDGYFYSWWTDGGAAATYTNLAGGEYSVSWSNGGNLVGGKGWNPGSARTITYSGTYNPNGNSYLAVYGWTRNPLVEYYVVENFGTYNPSSGATARGQVTHDGALYRLFESTRTNQPSIDGTATFQQYWAVRDVKRTGGTVNMATFFNAWTSAGMRLGTHNYQVVATEGYFSSGSARINVAGGGGSTPSPPSTPSPPTTPSPPPVTPPPSGGGSCAARWGQCGGSGWNGATCCSAGTCQAQNQWYSQCL" }, { "InterPro": [ { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 60, "End": 159 }, { "InterPro-ID": "IPR019778", "InterPro-Name": "Hydrophobin_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 129, "End": 140 }, { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 60, "End": 157 } ], "response#1": "MQFSISALVLGLAATVYALPPGAPSAGGAGSGNGVGNKGNTDVRFSVPDNMTVKQAQAKCGDQAQLSCCNKAVYAGDTTDINSGILGGTLSNLIGSGSGASGLGLFDQCSKLDLQIPVLIGIPIQDLINQKCKQNIACCQNSPSSANSDLIGLGLPCVALGSIL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Hydrophobin, Hydrophobin that shares evolutionary origin and functional similarity; 2. The protein should contain Hydrophobin_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MQFSISALVLGLAATVYALPPGAPSAGGAGSGNGVGNKGNTDVRFSVPDNMTVKQAQAKCGDQAQLSCCNKAVYAGDTTDINSGILGGTLSNLIGSGSGASGLGLFDQCSKLDLQIPVLIGIPIQDLINQKCKQNIACCQNSPSSANSDLIGLGLPCVALGSIL" }, { "InterPro": [ { "InterPro-ID": "IPR036388", "InterPro-Name": "WH-like_DNA-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 3, "End": 88 }, { "InterPro-ID": "IPR000847", "InterPro-Name": "Tscrpt_reg_HTH_LysR", "InterPro-Type": "DOMAIN", "Beg": 3, "End": 60 }, { "InterPro-ID": "IPR036390", "InterPro-Name": "WH_DNA-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 3, "End": 113 }, { "InterPro-ID": "IPR000847", "InterPro-Name": "Tscrpt_reg_HTH_LysR", "InterPro-Type": "DOMAIN", "Beg": 5, "End": 63 }, { "InterPro-ID": "IPR005119", "InterPro-Name": "LysR_subst-bd", "InterPro-Type": "DOMAIN", "Beg": 89, "End": 296 } ], "response#1": "MTHDLNDTLIFVKVVEQGSFIAAANSLGLPKTTVSRKVQELETRLGARLLHRTTRRIGLTEAGAVYHEHCQRIARELEEAESAVGQLQSGPRGWLRFTVPYSLGITWIAPLLGEFHAQYPEIQLDMHLGNEKLDLIGGEADLALRVGALPDSNLVARKLGSLRTQVFASPSYIERYGEPLHPDELQFHRTLALRKNRNVHNNRFFWSLSDGSDVREFPVNPLMVANDPAALNGAVLCGEGLLLTGDVMAKPFVQSGMVRRVLAGWTGPEVDFNAVFAGGRLVSPKVRAFVDFLVTRLNFDADYMMAQCPARLAAQRANGDAEVEVEVEAELRAEGKRILEKATA", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Tscrpt_reg_HTH_LysR, Tscrpt_reg_HTH_LysR, LysR_subst-bd that are essential for its biological function; 2. The protein should be classified within WH-like_DNA-bd_sf, WH_DNA-bd_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MTHDLNDTLIFVKVVEQGSFIAAANSLGLPKTTVSRKVQELETRLGARLLHRTTRRIGLTEAGAVYHEHCQRIARELEEAESAVGQLQSGPRGWLRFTVPYSLGITWIAPLLGEFHAQYPEIQLDMHLGNEKLDLIGGEADLALRVGALPDSNLVARKLGSLRTQVFASPSYIERYGEPLHPDELQFHRTLALRKNRNVHNNRFFWSLSDGSDVREFPVNPLMVANDPAALNGAVLCGEGLLLTGDVMAKPFVQSGMVRRVLAGWTGPEVDFNAVFAGGRLVSPKVRAFVDFLVTRLNFDADYMMAQCPARLAAQRANGDAEVEVEVEAELRAEGKRILEKATA" }, { "InterPro": [ { "InterPro-ID": "IPR003675", "InterPro-Name": "Rce1/LyrA-like_dom", "InterPro-Type": "DOMAIN", "Beg": 120, "End": 214 } ], "response#1": "MKNNKISGFQWAMTIFVFFVITMALSIMLRDFQSIIGVKHFIFEVTDLAPLIAAIICILVFKYKKVQLAGLKFSISLKVIERLLLALILPLIILIIGMYSFNTFADSFILLQSTGLSVPITHILIGHILMAFVVEFGFRSYLQNIVETKMNTFFASIVVGLMYSVFSANTTYGTEFAAYNFLYTFSFSMILGELIRATKGRTIYIATTFHASMTFGLIFLFSEEIGDLFSIKVIAISTAIVAVGYIGLSLIIRGIAYLTTRRNLEELEPNNYLDHVNDDEETNHTEAEKSSSNIKDAEKTGVATASTVGVAKNDTENTVADEPSIHEGTEKTEPQHHIGNQTESNHDEDHDITSESVESAESVKQAPQSDDLTNDSNEDEIEQSLKEPVTYKEDRRSSVVIDAEKHIEKTEEQSSDKNK", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Rce1/LyrA-like_dom that are essential for its biological function. The designed protein sequence is ", "reference": "MKNNKISGFQWAMTIFVFFVITMALSIMLRDFQSIIGVKHFIFEVTDLAPLIAAIICILVFKYKKVQLAGLKFSISLKVIERLLLALILPLIILIIGMYSFNTFADSFILLQSTGLSVPITHILIGHILMAFVVEFGFRSYLQNIVETKMNTFFASIVVGLMYSVFSANTTYGTEFAAYNFLYTFSFSMILGELIRATKGRTIYIATTFHASMTFGLIFLFSEEIGDLFSIKVIAISTAIVAVGYIGLSLIIRGIAYLTTRRNLEELEPNNYLDHVNDDEETNHTEAEKSSSNIKDAEKTGVATASTVGVAKNDTENTVADEPSIHEGTEKTEPQHHIGNQTESNHDEDHDITSESVESAESVKQAPQSDDLTNDSNEDEIEQSLKEPVTYKEDRRSSVVIDAEKHIEKTEEQSSDKNK" }, { "InterPro": [ { "InterPro-ID": "IPR001138", "InterPro-Name": "Zn2Cys6_DnaBD", "InterPro-Type": "DOMAIN", "Beg": 136, "End": 172 }, { "InterPro-ID": "IPR001138", "InterPro-Name": "Zn2Cys6_DnaBD", "InterPro-Type": "DOMAIN", "Beg": 136, "End": 164 }, { "InterPro-ID": "IPR001138", "InterPro-Name": "Zn2Cys6_DnaBD", "InterPro-Type": "DOMAIN", "Beg": 131, "End": 175 }, { "InterPro-ID": "IPR001138", "InterPro-Name": "Zn2Cys6_DnaBD", "InterPro-Type": "DOMAIN", "Beg": 132, "End": 167 }, { "InterPro-ID": "IPR007219", "InterPro-Name": "Transcription_factor_dom_fun", "InterPro-Type": "DOMAIN", "Beg": 392, "End": 474 }, { "InterPro-ID": "IPR007219", "InterPro-Name": "Transcription_factor_dom_fun", "InterPro-Type": "DOMAIN", "Beg": 291, "End": 475 }, { "InterPro-ID": "IPR036864", "InterPro-Name": "Zn2-C6_fun-type_DNA-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 127, "End": 172 }, { "InterPro-ID": "IPR036864", "InterPro-Name": "Zn2-C6_fun-type_DNA-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 135, "End": 215 }, { "InterPro-ID": "IPR050815", "InterPro-Name": "TF_fung", "InterPro-Type": "FAMILY", "Beg": 80, "End": 857 }, { "InterPro-ID": "IPR001138", "InterPro-Name": "Zn2Cys6_DnaBD", "InterPro-Type": "DOMAIN", "Beg": 136, "End": 166 } ], "response#1": "MDFTNFDDFAFAYYGLPVRASLVSLVDHTHTFQSPTALPQHQAISGLAHSGLPFGTLPTGNRNQSMEGSKAHPDRTSPASEAPEDPTTDEFGLASRSRAGGIDPGGKPKEDKADATPAWSELKTKAGKERKRLPLACVACRRKKSRCSGEKPACEHCLRSYIPCVYKVTTRKAAPRTNCMAMLDKRPKRMEERVIEAISKSDQEVASSVTRPVVKPAIPGTVPSSQPTKKRGAEEAFGPDLEAWAKAPSEPKTEGDDGSSSLQVQEGEENKLQHEGTDALPSKEIQEHLAEVFFDNIYGQSYHLLHKPSYMRKLKNGTLPPVLVLTVCAVAARFTSSPLVSSSGPEFLRGEEWASHARDICTRRYEWPNLTILTCLLILGLHEFGTCQGGRSWALGGQAIRMAFALQLHKDLEYDPLDRNGTKTQLSFIDREIRRRIMWACFLMDRFNSSGTDRPMFVREDTIQIPLPVKEKYFQFGLPAPTEMLDGRVPHPPSPNDGQIADVRENMGVAAFLIRAITLWGRITTYLSQGCKDLDPNPLWEDESHHMKHLNDAVNLEASLPLSLKYSAENLEVHKTENTPSQFLFMHICLQHNILLVSRAAMSARKQHGVHDDFFFEASKRTFNAANRISELLREAEQSGCFVSAPFAGYCAFSSATVHSVGIISRNPSMKLAAQANLTTNVKYLHKMKKYWGMFHWMVENVRTQYQNVLDAMRAGANVEERATQLSFLQYGDWFNRYPRGLSHAEFMDPATHKRKDSGADGVLEANPELRSVEEYFTLPTPQRVENKDTISAAAPKRKQNAKKQTDMPAQSDRNLDWLQSTDADAVSQERKLSGGLGLQITGSAGFNPLTASNQQSPDFSTTMLPMSPVNMTSFAHHAHTPTFFPPQPFAMNFGQGSNGNIDPLDRQFIYGGYSMDASTSLGDGHTWAL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Zn2Cys6_DnaBD, Zn2Cys6_DnaBD, Zn2Cys6_DnaBD, Zn2Cys6_DnaBD, Transcription_factor_dom_fun, Transcription_factor_dom_fun, Zn2Cys6_DnaBD that are essential for its biological function; 2. The protein should belong to TF_fung that shares evolutionary origin and functional similarity; 3. The protein should be classified within Zn2-C6_fun-type_DNA-bd_sf, Zn2-C6_fun-type_DNA-bd_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MDFTNFDDFAFAYYGLPVRASLVSLVDHTHTFQSPTALPQHQAISGLAHSGLPFGTLPTGNRNQSMEGSKAHPDRTSPASEAPEDPTTDEFGLASRSRAGGIDPGGKPKEDKADATPAWSELKTKAGKERKRLPLACVACRRKKSRCSGEKPACEHCLRSYIPCVYKVTTRKAAPRTNCMAMLDKRPKRMEERVIEAISKSDQEVASSVTRPVVKPAIPGTVPSSQPTKKRGAEEAFGPDLEAWAKAPSEPKTEGDDGSSSLQVQEGEENKLQHEGTDALPSKEIQEHLAEVFFDNIYGQSYHLLHKPSYMRKLKNGTLPPVLVLTVCAVAARFTSSPLVSSSGPEFLRGEEWASHARDICTRRYEWPNLTILTCLLILGLHEFGTCQGGRSWALGGQAIRMAFALQLHKDLEYDPLDRNGTKTQLSFIDREIRRRIMWACFLMDRFNSSGTDRPMFVREDTIQIPLPVKEKYFQFGLPAPTEMLDGRVPHPPSPNDGQIADVRENMGVAAFLIRAITLWGRITTYLSQGCKDLDPNPLWEDESHHMKHLNDAVNLEASLPLSLKYSAENLEVHKTENTPSQFLFMHICLQHNILLVSRAAMSARKQHGVHDDFFFEASKRTFNAANRISELLREAEQSGCFVSAPFAGYCAFSSATVHSVGIISRNPSMKLAAQANLTTNVKYLHKMKKYWGMFHWMVENVRTQYQNVLDAMRAGANVEERATQLSFLQYGDWFNRYPRGLSHAEFMDPATHKRKDSGADGVLEANPELRSVEEYFTLPTPQRVENKDTISAAAPKRKQNAKKQTDMPAQSDRNLDWLQSTDADAVSQERKLSGGLGLQITGSAGFNPLTASNQQSPDFSTTMLPMSPVNMTSFAHHAHTPTFFPPQPFAMNFGQGSNGNIDPLDRQFIYGGYSMDASTSLGDGHTWAL" }, { "InterPro": [ { "InterPro-ID": "IPR001138", "InterPro-Name": "Zn2Cys6_DnaBD", "InterPro-Type": "DOMAIN", "Beg": 136, "End": 164 }, { "InterPro-ID": "IPR001138", "InterPro-Name": "Zn2Cys6_DnaBD", "InterPro-Type": "DOMAIN", "Beg": 136, "End": 172 }, { "InterPro-ID": "IPR001138", "InterPro-Name": "Zn2Cys6_DnaBD", "InterPro-Type": "DOMAIN", "Beg": 132, "End": 167 }, { "InterPro-ID": "IPR027443", "InterPro-Name": "IPNS-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 874, "End": 996 }, { "InterPro-ID": "IPR036864", "InterPro-Name": "Zn2-C6_fun-type_DNA-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 135, "End": 213 }, { "InterPro-ID": "IPR050815", "InterPro-Name": "TF_fung", "InterPro-Type": "FAMILY", "Beg": 340, "End": 746 }, { "InterPro-ID": "IPR007219", "InterPro-Name": "Transcription_factor_dom_fun", "InterPro-Type": "DOMAIN", "Beg": 343, "End": 425 }, { "InterPro-ID": "IPR007219", "InterPro-Name": "Transcription_factor_dom_fun", "InterPro-Type": "DOMAIN", "Beg": 344, "End": 491 }, { "InterPro-ID": "IPR007219", "InterPro-Name": "Transcription_factor_dom_fun", "InterPro-Type": "DOMAIN", "Beg": 291, "End": 339 }, { "InterPro-ID": "IPR001138", "InterPro-Name": "Zn2Cys6_DnaBD", "InterPro-Type": "DOMAIN", "Beg": 136, "End": 166 }, { "InterPro-ID": "IPR036864", "InterPro-Name": "Zn2-C6_fun-type_DNA-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 127, "End": 172 }, { "InterPro-ID": "IPR001138", "InterPro-Name": "Zn2Cys6_DnaBD", "InterPro-Type": "DOMAIN", "Beg": 131, "End": 175 } ], "response#1": "MDFTHFDDVAFAYYGLPDQSSLVSLLDHTHTFQSPTAFPQHQAMSGLAHSGLPFGTLPTGNRSQSMEGSKAPPDRTSPASNAFENPTTDEFGLASCNRADGTDLGGKPREDKAGATPAWSGLKTKAGKERKRLPLACIACRRKKVRCSGEKPACKHCLHSHIPCVYKVTTRKAAPRTNYMVMLDKRPKCMEERIIKATPKSDQEVASFVTRPVVKPAIPGAVPSSKPTKKRGAEEAFGLDLEAWAKAPSKPKIEGDDRPSSLQAQEGEENKLQHEGTEALPSEEIQEHLAEVFFDNIYGQSYHLLHKPSYLRKLKNGTLPPVLVLTVCAVAARFTSNPLGGRSWALGGQAIRMAFALQLHKDLEYDPSGRNGAKTQLSFIDREIRRRIMWACFLLDRFNSSGTDRPMFIREDTIQIPLPVKEKYFQFDMPAPTELLDGQVPHPPSPNDGQIADARENMGVAAFLIRAIALWGRIITYLSQGCKDLDPNLLWEEEPHYIKHLNDAVNLEASLPLSLNYSAENLEVHKTENAASQFLFMHICLQHNILLVSRAAMSARKQQGVHDDFFSEASQRTFSAANRISEFLREAEQSRCFVSAPFAGYCAFSSATVHILGIISCNPSMKPTAEANLTTNVKYLHKMKKYWERATQLSFLQYGDWYNRYPRGLSDAEFMDPATHKRKDSGADGVLEAKPELRSVEEYSTLPTPRRVENKDTIRAAAPKRKQSAKKQTGMPAQPGQHLDSLQSTDADAVSQERKFSGGLGLQITGAAGFNPLSASNQQNPDFSTTMSPTSPANMTPFSHYAHTPTFFPPELLSIDFGQGSNGNIDPLDRQLIYGGYSMDASTGLCGGQDMMSGLGWDTVASGAQPDGCLQGRPPNVKAGMHGQSAASSSFPAINKTNGKGKEGRGIGSHTDYGLLVIAAADDVGGDMMQYMTNSVLPSTPHKVGLNLRERFAFAYFHEPSFQAVVRPLPGYDHGQEPKGGIHYGKQFTDMFMRNYPQRITTQRLNDEGRYRLLDQESLQTMSP", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Zn2Cys6_DnaBD, Zn2Cys6_DnaBD, Zn2Cys6_DnaBD, Transcription_factor_dom_fun, Transcription_factor_dom_fun, Transcription_factor_dom_fun, Zn2Cys6_DnaBD, Zn2Cys6_DnaBD that are essential for its biological function; 2. The protein should belong to TF_fung that shares evolutionary origin and functional similarity; 3. The protein should be classified within IPNS-like_sf, Zn2-C6_fun-type_DNA-bd_sf, Zn2-C6_fun-type_DNA-bd_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MDFTHFDDVAFAYYGLPDQSSLVSLLDHTHTFQSPTAFPQHQAMSGLAHSGLPFGTLPTGNRSQSMEGSKAPPDRTSPASNAFENPTTDEFGLASCNRADGTDLGGKPREDKAGATPAWSGLKTKAGKERKRLPLACIACRRKKVRCSGEKPACKHCLHSHIPCVYKVTTRKAAPRTNYMVMLDKRPKCMEERIIKATPKSDQEVASFVTRPVVKPAIPGAVPSSKPTKKRGAEEAFGLDLEAWAKAPSKPKIEGDDRPSSLQAQEGEENKLQHEGTEALPSEEIQEHLAEVFFDNIYGQSYHLLHKPSYLRKLKNGTLPPVLVLTVCAVAARFTSNPLGGRSWALGGQAIRMAFALQLHKDLEYDPSGRNGAKTQLSFIDREIRRRIMWACFLLDRFNSSGTDRPMFIREDTIQIPLPVKEKYFQFDMPAPTELLDGQVPHPPSPNDGQIADARENMGVAAFLIRAIALWGRIITYLSQGCKDLDPNLLWEEEPHYIKHLNDAVNLEASLPLSLNYSAENLEVHKTENAASQFLFMHICLQHNILLVSRAAMSARKQQGVHDDFFSEASQRTFSAANRISEFLREAEQSRCFVSAPFAGYCAFSSATVHILGIISCNPSMKPTAEANLTTNVKYLHKMKKYWERATQLSFLQYGDWYNRYPRGLSDAEFMDPATHKRKDSGADGVLEAKPELRSVEEYSTLPTPRRVENKDTIRAAAPKRKQSAKKQTGMPAQPGQHLDSLQSTDADAVSQERKFSGGLGLQITGAAGFNPLSASNQQNPDFSTTMSPTSPANMTPFSHYAHTPTFFPPELLSIDFGQGSNGNIDPLDRQLIYGGYSMDASTGLCGGQDMMSGLGWDTVASGAQPDGCLQGRPPNVKAGMHGQSAASSSFPAINKTNGKGKEGRGIGSHTDYGLLVIAAADDVGGDMMQYMTNSVLPSTPHKVGLNLRERFAFAYFHEPSFQAVVRPLPGYDHGQEPKGGIHYGKQFTDMFMRNYPQRITTQRLNDEGRYRLLDQESLQTMSP" }, { "InterPro": [ { "InterPro-ID": "IPR007219", "InterPro-Name": "Transcription_factor_dom_fun", "InterPro-Type": "DOMAIN", "Beg": 433, "End": 515 }, { "InterPro-ID": "IPR001138", "InterPro-Name": "Zn2Cys6_DnaBD", "InterPro-Type": "DOMAIN", "Beg": 177, "End": 205 }, { "InterPro-ID": "IPR001138", "InterPro-Name": "Zn2Cys6_DnaBD", "InterPro-Type": "DOMAIN", "Beg": 177, "End": 213 }, { "InterPro-ID": "IPR050815", "InterPro-Name": "TF_fung", "InterPro-Type": "FAMILY", "Beg": 114, "End": 865 }, { "InterPro-ID": "IPR001138", "InterPro-Name": "Zn2Cys6_DnaBD", "InterPro-Type": "DOMAIN", "Beg": 172, "End": 216 }, { "InterPro-ID": "IPR001138", "InterPro-Name": "Zn2Cys6_DnaBD", "InterPro-Type": "DOMAIN", "Beg": 173, "End": 208 }, { "InterPro-ID": "IPR001138", "InterPro-Name": "Zn2Cys6_DnaBD", "InterPro-Type": "DOMAIN", "Beg": 177, "End": 207 }, { "InterPro-ID": "IPR007219", "InterPro-Name": "Transcription_factor_dom_fun", "InterPro-Type": "DOMAIN", "Beg": 332, "End": 569 }, { "InterPro-ID": "IPR036864", "InterPro-Name": "Zn2-C6_fun-type_DNA-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 168, "End": 213 }, { "InterPro-ID": "IPR036864", "InterPro-Name": "Zn2-C6_fun-type_DNA-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 176, "End": 258 } ], "response#1": "MSGRAVSNPQHAQQSFDSGPQLYRDVPELHAVPSPSHSALMDSTHFDDFAFAYHGLPDQSSLVSLADHTHTSQSPTAFPQHQAMSGLAHSGLPFGTLPTGNRSQSMEGSELPPPDRTSPASNALEDPTTDEFGLASRNRADGTDLGGKHKEDKVDATPAWSELKTKAGKERKRLPLACMACRRKKIRCSGEKPACKHCLRSRILCVYKVTTRKAAPRTGYIAMLDKPLKRMEERIIKVIPKSDQEVASSVTRAVVKPVIPGTVPSSKPTKKRGAEEVFGPDLDAWAKAPSKPKIEGDDRPSCLQVQEAEENMLQHEGAEALPSKEIQEHLAEVFFDNIYGQSYHLLHKPSYMRKLKNGTLPPVLVLTVCAVAARFTSNPLVSSSGPELLRGEEWASHAQDICTRRYEWPNLTILTCLLILGLHEFGTCQSGRSWALGGHAIRMAFALQLHKDLEYDPSGRHSTKTQLSFIDREIRRRIMWACFLMDRFNSSGTDRPMFIREDTIQIPLPVKEKYFQFDLPAPTEMLDGQVPHPVSPNDGQIADARENMGVAAFLIRAIALWGRIITYLSQGGKDLDPNPMWEDESHYVKHLNDVVNLEASLPLSLKYSAENLEVHKTENTASQFLFMHICLQHNILFVSRAAMSARKQRGVHDDFFSEASKRTFDAANRISELLREAEQLRCFVSAPFAGYCAFSSTTVHILGIISRNPSMKLAAQANLTTNVKYLHKMKKYWGMFHWMVENVHTQYRNALDAMRAGANVQERATQSSFLQYGDWFNCYPHGLSDAEFMDPATLKRKDSGADGVLEAKSELQSVEEYFSTLPTPRSAENKDTIRAAAPKRKQSAKKQTGMPAQPGQHLDSLQSTDADAVSQERKFSGGLGLQTTGAADFNPLAASNPQNPAFSTTMPPTSPANMTAFAHHAYTPTFFPPELLAMNFGQGSNGNIDPLDRQLVYGGYSMDASTGLGDGQDMTSGLDWDTVASGAQPDGGLQGRRSNVKAGMHGQSAGMADGAGLSGLEASSAWFMPFNMEPPDIGQDPGFNMGGIDPFAGVFGGGGSGLATPNALGGLQQQGP", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Transcription_factor_dom_fun, Zn2Cys6_DnaBD, Zn2Cys6_DnaBD, Zn2Cys6_DnaBD, Zn2Cys6_DnaBD, Zn2Cys6_DnaBD, Transcription_factor_dom_fun that are essential for its biological function; 2. The protein should belong to TF_fung that shares evolutionary origin and functional similarity; 3. The protein should be classified within Zn2-C6_fun-type_DNA-bd_sf, Zn2-C6_fun-type_DNA-bd_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MSGRAVSNPQHAQQSFDSGPQLYRDVPELHAVPSPSHSALMDSTHFDDFAFAYHGLPDQSSLVSLADHTHTSQSPTAFPQHQAMSGLAHSGLPFGTLPTGNRSQSMEGSELPPPDRTSPASNALEDPTTDEFGLASRNRADGTDLGGKHKEDKVDATPAWSELKTKAGKERKRLPLACMACRRKKIRCSGEKPACKHCLRSRILCVYKVTTRKAAPRTGYIAMLDKPLKRMEERIIKVIPKSDQEVASSVTRAVVKPVIPGTVPSSKPTKKRGAEEVFGPDLDAWAKAPSKPKIEGDDRPSCLQVQEAEENMLQHEGAEALPSKEIQEHLAEVFFDNIYGQSYHLLHKPSYMRKLKNGTLPPVLVLTVCAVAARFTSNPLVSSSGPELLRGEEWASHAQDICTRRYEWPNLTILTCLLILGLHEFGTCQSGRSWALGGHAIRMAFALQLHKDLEYDPSGRHSTKTQLSFIDREIRRRIMWACFLMDRFNSSGTDRPMFIREDTIQIPLPVKEKYFQFDLPAPTEMLDGQVPHPVSPNDGQIADARENMGVAAFLIRAIALWGRIITYLSQGGKDLDPNPMWEDESHYVKHLNDVVNLEASLPLSLKYSAENLEVHKTENTASQFLFMHICLQHNILFVSRAAMSARKQRGVHDDFFSEASKRTFDAANRISELLREAEQLRCFVSAPFAGYCAFSSTTVHILGIISRNPSMKLAAQANLTTNVKYLHKMKKYWGMFHWMVENVHTQYRNALDAMRAGANVQERATQSSFLQYGDWFNCYPHGLSDAEFMDPATLKRKDSGADGVLEAKSELQSVEEYFSTLPTPRSAENKDTIRAAAPKRKQSAKKQTGMPAQPGQHLDSLQSTDADAVSQERKFSGGLGLQTTGAADFNPLAASNPQNPAFSTTMPPTSPANMTAFAHHAYTPTFFPPELLAMNFGQGSNGNIDPLDRQLVYGGYSMDASTGLGDGQDMTSGLDWDTVASGAQPDGGLQGRRSNVKAGMHGQSAGMADGAGLSGLEASSAWFMPFNMEPPDIGQDPGFNMGGIDPFAGVFGGGGSGLATPNALGGLQQQGP" }, { "InterPro": [ { "InterPro-ID": "IPR001138", "InterPro-Name": "Zn2Cys6_DnaBD", "InterPro-Type": "DOMAIN", "Beg": 131, "End": 175 }, { "InterPro-ID": "IPR036864", "InterPro-Name": "Zn2-C6_fun-type_DNA-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 127, "End": 172 }, { "InterPro-ID": "IPR001138", "InterPro-Name": "Zn2Cys6_DnaBD", "InterPro-Type": "DOMAIN", "Beg": 136, "End": 164 }, { "InterPro-ID": "IPR001138", "InterPro-Name": "Zn2Cys6_DnaBD", "InterPro-Type": "DOMAIN", "Beg": 132, "End": 167 }, { "InterPro-ID": "IPR050815", "InterPro-Name": "TF_fung", "InterPro-Type": "FAMILY", "Beg": 75, "End": 821 }, { "InterPro-ID": "IPR007219", "InterPro-Name": "Transcription_factor_dom_fun", "InterPro-Type": "DOMAIN", "Beg": 291, "End": 540 }, { "InterPro-ID": "IPR007219", "InterPro-Name": "Transcription_factor_dom_fun", "InterPro-Type": "DOMAIN", "Beg": 392, "End": 474 }, { "InterPro-ID": "IPR001138", "InterPro-Name": "Zn2Cys6_DnaBD", "InterPro-Type": "DOMAIN", "Beg": 136, "End": 166 }, { "InterPro-ID": "IPR001138", "InterPro-Name": "Zn2Cys6_DnaBD", "InterPro-Type": "DOMAIN", "Beg": 136, "End": 172 }, { "InterPro-ID": "IPR036864", "InterPro-Name": "Zn2-C6_fun-type_DNA-bd_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 135, "End": 215 } ], "response#1": "MDFTHFDDFAFAYYGLPDQASLASLVDHTHMFQSPTAFPQHQAMSGLAHSGLPLGTLPTGNRSQSMEGSKAPPDRTSPASNALEDPTTDEFGLASRNRVGGIDLGGKPKEDKADATPAWSGLKTKAGKERKRLPLACIPCRRKKIRCSGEKPACEHCLRSYIPCVYKITTRKAAPRTDYMAMLDKRPKCMEERVIKAIPKSDQEVASSVTRPVVKPAIPGTVPSSKPTKKRSAEEAFGPDLEACAKAPSEPKIEGDNGPSNLQVQEGEENKLQHEGTEALPSKDIQEHLADVFFDNIYGQSYHLLHKPSYMRKLKNGTLPPVLVLTVCAVAARFTSNPLVSSSGPEFLRGEEWASHARDICTKRYEWPNLTILTCLLILGLHEFGTCQGGRSWALGGQAIRMAFALQLHKDLEYDPSGRNGTKTQLSFIDREIRRRIMWACFLMDRFNSSGTDRPMFIREDTIQIPLPVKEKYFQFGMPAPTEMLDGRVPHPPSPNDGQIADVRENMGVAAFLIRAIALWGRITTCLSQGCKDLDSNPLWEGKSHYMNHLNDAVNLEASLPLSLKYSAENLEVHKTENTPSQFLFMHICLQHNILLVSRAAMSARKQHGVHDDFFSEASKRTFNAANRISELLREAEQSGCFVSAPFAGYCAFSSTTVHILAIISRNPSMKLTAEANLTTNVKYLHKMKKYWGMFHWMVENVRTQYRNVLDAMRAGANVEERATQLSFLQYGDWFNRYPRGLSDAEFMDPATHKRKDSGADGVLDAKPELRSVEKYFTLPTPRRVENKDTIRAAAPKRKQSAKKQTGMPAQPGQHLDSLQSIDADAVSQEHKFSGGLGLQITGAAGFNPLAASNQQNPDFSTTMSPTSPANMTAFAHYAHTPTFFPPELLAMNFGQDSNGNIDPLDRQLIYGGYSMDASTGLGHGHTWSL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Zn2Cys6_DnaBD, Zn2Cys6_DnaBD, Zn2Cys6_DnaBD, Transcription_factor_dom_fun, Transcription_factor_dom_fun, Zn2Cys6_DnaBD, Zn2Cys6_DnaBD that are essential for its biological function; 2. The protein should belong to TF_fung that shares evolutionary origin and functional similarity; 3. The protein should be classified within Zn2-C6_fun-type_DNA-bd_sf, Zn2-C6_fun-type_DNA-bd_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MDFTHFDDFAFAYYGLPDQASLASLVDHTHMFQSPTAFPQHQAMSGLAHSGLPLGTLPTGNRSQSMEGSKAPPDRTSPASNALEDPTTDEFGLASRNRVGGIDLGGKPKEDKADATPAWSGLKTKAGKERKRLPLACIPCRRKKIRCSGEKPACEHCLRSYIPCVYKITTRKAAPRTDYMAMLDKRPKCMEERVIKAIPKSDQEVASSVTRPVVKPAIPGTVPSSKPTKKRSAEEAFGPDLEACAKAPSEPKIEGDNGPSNLQVQEGEENKLQHEGTEALPSKDIQEHLADVFFDNIYGQSYHLLHKPSYMRKLKNGTLPPVLVLTVCAVAARFTSNPLVSSSGPEFLRGEEWASHARDICTKRYEWPNLTILTCLLILGLHEFGTCQGGRSWALGGQAIRMAFALQLHKDLEYDPSGRNGTKTQLSFIDREIRRRIMWACFLMDRFNSSGTDRPMFIREDTIQIPLPVKEKYFQFGMPAPTEMLDGRVPHPPSPNDGQIADVRENMGVAAFLIRAIALWGRITTCLSQGCKDLDSNPLWEGKSHYMNHLNDAVNLEASLPLSLKYSAENLEVHKTENTPSQFLFMHICLQHNILLVSRAAMSARKQHGVHDDFFSEASKRTFNAANRISELLREAEQSGCFVSAPFAGYCAFSSTTVHILAIISRNPSMKLTAEANLTTNVKYLHKMKKYWGMFHWMVENVRTQYRNVLDAMRAGANVEERATQLSFLQYGDWFNRYPRGLSDAEFMDPATHKRKDSGADGVLDAKPELRSVEKYFTLPTPRRVENKDTIRAAAPKRKQSAKKQTGMPAQPGQHLDSLQSIDADAVSQEHKFSGGLGLQITGAAGFNPLAASNQQNPDFSTTMSPTSPANMTAFAHYAHTPTFFPPELLAMNFGQDSNGNIDPLDRQLIYGGYSMDASTGLGHGHTWSL" }, { "InterPro": [ { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 54, "End": 140 }, { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 54, "End": 137 } ], "response#1": "MLSHPMKLLFFVFALSALLAAATPVVEVRDYQQFSRVSLINFISFNKARGGDLCANGKKTMCCGELKTFDKNILGLLDGLLTTVVGLAGEILKPTGLVGLECVPITLLGNGGLSDVCKANGVCCKDLTLRAAINVGCVPINIL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Hydrophobin, Hydrophobin that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MLSHPMKLLFFVFALSALLAAATPVVEVRDYQQFSRVSLINFISFNKARGGDLCANGKKTMCCGELKTFDKNILGLLDGLLTTVVGLAGEILKPTGLVGLECVPITLLGNGGLSDVCKANGVCCKDLTLRAAINVGCVPINIL" }, { "InterPro": [ { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 27, "End": 99 }, { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 27, "End": 102 } ], "response#1": "MFSKATLFFTAAVVIVAAGATPTTSQCNTGPVQCCDHTQQASGPTTLTGIGEVDLGDTSTLIAYGNCSPVLPVLGGPKCQGQTVCCDNTEFEGLVNVGCTNVAV", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Hydrophobin, Hydrophobin that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MFSKATLFFTAAVVIVAAGATPTTSQCNTGPVQCCDHTQQASGPTTLTGIGEVDLGDTSTLIAYGNCSPVLPVLGGPKCQGQTVCCDNTEFEGLVNVGCTNVAV" }, { "InterPro": [ { "InterPro-ID": "IPR035985", "InterPro-Name": "Ubiquitin-activating_enz", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 2, "End": 356 }, { "InterPro-ID": "IPR001763", "InterPro-Name": "Rhodanese-like_dom", "InterPro-Type": "DOMAIN", "Beg": 288, "End": 384 }, { "InterPro-ID": "IPR000594", "InterPro-Name": "ThiF_NAD_FAD-bd", "InterPro-Type": "DOMAIN", "Beg": 11, "End": 254 }, { "InterPro-ID": "IPR036873", "InterPro-Name": "Rhodanese-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 290, "End": 389 }, { "InterPro-ID": "IPR001763", "InterPro-Name": "Rhodanese-like_dom", "InterPro-Type": "DOMAIN", "Beg": 297, "End": 380 }, { "InterPro-ID": "IPR045886", "InterPro-Name": "ThiF/MoeB/HesA", "InterPro-Type": "FAMILY", "Beg": 7, "End": 293 }, { "InterPro-ID": "IPR028885", "InterPro-Name": "MOCS3/Uba4", "InterPro-Type": "FAMILY", "Beg": 1, "End": 389 }, { "InterPro-ID": "IPR001763", "InterPro-Name": "Rhodanese-like_dom", "InterPro-Type": "DOMAIN", "Beg": 298, "End": 387 } ], "response#1": "MSLSLNEYLRYGRQLIVPEFGLQGQISLKNSRVLVVGAGGLGCPALQYLVGAGFGTVGIVDHDTVDISNLHRQILHTSETVEMLKCESAKLQLAKLNPLVQINTHPVALSPDNSFGIFEQYDIILDCTDTPATRYLINDTAVLLGLTVISGSGLKTEGQLSILNFNNTGPCYRCFYPTPPPPSSVTACSDGGVLGPVIGIMGVMMALEAIKVVSGYYLREDVEFQPFLSLYSGYGPLQSLRTFKMRRRSPKCRVCNAGTREITRHVIETELDYAVWCGKMDYNVLEKDERVSVEQLSAQRAPYLVDVRAKEQYSIVHLPNSINIPLNALKHMDTLDVPKETMIYVICRFGNDSQLAVKHLKSIGYENCVDVIGGLTQWSRQIDPNFPIY", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Rhodanese-like_dom, ThiF_NAD_FAD-bd, Rhodanese-like_dom, Rhodanese-like_dom that are essential for its biological function; 2. The protein should belong to ThiF/MoeB/HesA, MOCS3/Uba4 that shares evolutionary origin and functional similarity; 3. The protein should be classified within Ubiquitin-activating_enz, Rhodanese-like_dom_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MSLSLNEYLRYGRQLIVPEFGLQGQISLKNSRVLVVGAGGLGCPALQYLVGAGFGTVGIVDHDTVDISNLHRQILHTSETVEMLKCESAKLQLAKLNPLVQINTHPVALSPDNSFGIFEQYDIILDCTDTPATRYLINDTAVLLGLTVISGSGLKTEGQLSILNFNNTGPCYRCFYPTPPPPSSVTACSDGGVLGPVIGIMGVMMALEAIKVVSGYYLREDVEFQPFLSLYSGYGPLQSLRTFKMRRRSPKCRVCNAGTREITRHVIETELDYAVWCGKMDYNVLEKDERVSVEQLSAQRAPYLVDVRAKEQYSIVHLPNSINIPLNALKHMDTLDVPKETMIYVICRFGNDSQLAVKHLKSIGYENCVDVIGGLTQWSRQIDPNFPIY" }, { "InterPro": [ { "InterPro-ID": "IPR002919", "InterPro-Name": "TIL_dom", "InterPro-Type": "DOMAIN", "Beg": 23, "End": 75 }, { "InterPro-ID": "IPR036084", "InterPro-Name": "Ser_inhib-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 21, "End": 75 }, { "InterPro-ID": "IPR051368", "InterPro-Name": "SerProtInhib-TIL_Domain", "InterPro-Type": "FAMILY", "Beg": 21, "End": 75 } ], "response#1": "MSRILFVFLAVMAIFSTSFGQQCGLNEEFKSCGSCEPTCAKPRVTICTMECKIGCQCKSGYLRNGEGTCVLPEKC", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more TIL_dom that are essential for its biological function; 2. The protein should belong to SerProtInhib-TIL_Domain that shares evolutionary origin and functional similarity; 3. The protein should be classified within Ser_inhib-like_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MSRILFVFLAVMAIFSTSFGQQCGLNEEFKSCGSCEPTCAKPRVTICTMECKIGCQCKSGYLRNGEGTCVLPEKC" }, { "InterPro": [ { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 38, "End": 119 }, { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 38, "End": 121 } ], "response#1": "MQYMTIVAFLAATVAAGPQIRAYPSIDQITVAQANNACGNNMQVTCCNKVTNTPAGNAVGNGAGILNNLSLFDQCSKLDVNVLAIANGLLNKECQANAACCQNSGGSATGGLVNVALPCIALSSLI", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Hydrophobin, Hydrophobin that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MQYMTIVAFLAATVAAGPQIRAYPSIDQITVAQANNACGNNMQVTCCNKVTNTPAGNAVGNGAGILNNLSLFDQCSKLDVNVLAIANGLLNKECQANAACCQNSGGSATGGLVNVALPCIALSSLI" }, { "InterPro": [ { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 35, "End": 116 }, { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 35, "End": 119 } ], "response#1": "MYAYTVIAFLAASVAAAGNGPSISSLTVQQAANSCANGQSVYCCNKTSNKPAGNSVGDGAGIANGLSLFSQCSKVDVNVIAIANNLLNKECQANAACCQDSPGTAAAGLVNAALPCVAISNLV", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Hydrophobin, Hydrophobin that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MYAYTVIAFLAASVAAAGNGPSISSLTVQQAANSCANGQSVYCCNKTSNKPAGNSVGDGAGIANGLSLFSQCSKVDVNVIAIANNLLNKECQANAACCQDSPGTAAAGLVNAALPCVAISNLV" }, { "InterPro": [ { "InterPro-ID": "IPR036686", "InterPro-Name": "Hydrophobin_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 28, "End": 96 }, { "InterPro-ID": "IPR036686", "InterPro-Name": "Hydrophobin_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 18, "End": 96 }, { "InterPro-ID": "IPR010636", "InterPro-Name": "Cerato-ulmin_hydrophobin", "InterPro-Type": "FAMILY", "Beg": 1, "End": 94 }, { "InterPro-ID": "IPR010636", "InterPro-Name": "Cerato-ulmin_hydrophobin", "InterPro-Type": "FAMILY", "Beg": 29, "End": 92 }, { "InterPro-ID": "IPR010636", "InterPro-Name": "Cerato-ulmin_hydrophobin", "InterPro-Type": "FAMILY", "Beg": 30, "End": 93 } ], "response#1": "MQFSLALVTLLATAVSALPTEEKRQAYIPCSGLYGTSQCCATDVLGVADLDCGNPPSTPANATDFSAVCSAIGQRARCCVLPILDQGILCNTPTGVQD", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Cerato-ulmin_hydrophobin, Cerato-ulmin_hydrophobin, Cerato-ulmin_hydrophobin that shares evolutionary origin and functional similarity; 2. The protein should be classified within Hydrophobin_sf, Hydrophobin_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MQFSLALVTLLATAVSALPTEEKRQAYIPCSGLYGTSQCCATDVLGVADLDCGNPPSTPANATDFSAVCSAIGQRARCCVLPILDQGILCNTPTGVQD" }, { "InterPro": [ { "InterPro-ID": "IPR046462", "InterPro-Name": "TerL_nuclease", "InterPro-Type": "DOMAIN", "Beg": 212, "End": 483 }, { "InterPro-ID": "IPR027417", "InterPro-Name": "P-loop_NTPase", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 4, "End": 207 }, { "InterPro-ID": "IPR005021", "InterPro-Name": "Terminase_largesu-like", "InterPro-Type": "FAMILY", "Beg": 4, "End": 496 }, { "InterPro-ID": "IPR046461", "InterPro-Name": "TerL_ATPase", "InterPro-Type": "DOMAIN", "Beg": 43, "End": 190 } ], "response#1": "MTRGERVIAFIERFCIVPEGKLIGQPMRLDPFQKDFILAVYDNPAGTDMAILSIARKNGKTGLIAGILLAHLVGPEAVQNTQIVSGALSREQAAIVFNLAVKMVNLNPKLQEIVHITPSGKKLIGLPCNVEYKALSAEGKTTHGLSPILAILDETGQVRGPQDDFIDAITTAQGAHENPLLIVISTQAANDADLLSIWIDDAVKSKDPHIVCHVYEAPKDADISKRESWLAANPALGTFRSEKDMARQAEKAGRMPSFENTFRNLNLNQRVSTVSPFISRSVWELCGEMPINTPRKWYAGLDLSARNDLTALVIAGEADDGVWDVFPFFWTPQKTLEERTKTDRAPYDVWVREGLLRTTPGASVDYSFVVADIAEIIGDFDLTSMAFDRWRIDQFRKDADAIGLSLPLVEFGQGFKDMGPAVDTLESLMLNGRVRHGMHPVLTMCAVNAVVVKDAAGNRKLDKSKATGRIDGMVAMTMSVGAANGEVTEQGGDFDDFIFRPLSM", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more TerL_nuclease, TerL_ATPase that are essential for its biological function; 2. The protein should belong to Terminase_largesu-like that shares evolutionary origin and functional similarity; 3. The protein should be classified within P-loop_NTPase sharing conserved structural features. The designed protein sequence is ", "reference": "MTRGERVIAFIERFCIVPEGKLIGQPMRLDPFQKDFILAVYDNPAGTDMAILSIARKNGKTGLIAGILLAHLVGPEAVQNTQIVSGALSREQAAIVFNLAVKMVNLNPKLQEIVHITPSGKKLIGLPCNVEYKALSAEGKTTHGLSPILAILDETGQVRGPQDDFIDAITTAQGAHENPLLIVISTQAANDADLLSIWIDDAVKSKDPHIVCHVYEAPKDADISKRESWLAANPALGTFRSEKDMARQAEKAGRMPSFENTFRNLNLNQRVSTVSPFISRSVWELCGEMPINTPRKWYAGLDLSARNDLTALVIAGEADDGVWDVFPFFWTPQKTLEERTKTDRAPYDVWVREGLLRTTPGASVDYSFVVADIAEIIGDFDLTSMAFDRWRIDQFRKDADAIGLSLPLVEFGQGFKDMGPAVDTLESLMLNGRVRHGMHPVLTMCAVNAVVVKDAAGNRKLDKSKATGRIDGMVAMTMSVGAANGEVTEQGGDFDDFIFRPLSM" }, { "InterPro": [ { "InterPro-ID": "IPR001137", "InterPro-Name": "Glyco_hydro_11", "InterPro-Type": "FAMILY", "Beg": 144, "End": 150 }, { "InterPro-ID": "IPR001137", "InterPro-Name": "Glyco_hydro_11", "InterPro-Type": "FAMILY", "Beg": 164, "End": 169 }, { "InterPro-ID": "IPR001137", "InterPro-Name": "Glyco_hydro_11", "InterPro-Type": "FAMILY", "Beg": 192, "End": 200 }, { "InterPro-ID": "IPR001137", "InterPro-Name": "Glyco_hydro_11", "InterPro-Type": "FAMILY", "Beg": 106, "End": 115 }, { "InterPro-ID": "IPR001137", "InterPro-Name": "Glyco_hydro_11", "InterPro-Type": "FAMILY", "Beg": 116, "End": 126 }, { "InterPro-ID": "IPR001137", "InterPro-Name": "Glyco_hydro_11", "InterPro-Type": "FAMILY", "Beg": 169, "End": 178 }, { "InterPro-ID": "IPR033123", "InterPro-Name": "GH11_dom", "InterPro-Type": "DOMAIN", "Beg": 43, "End": 220 }, { "InterPro-ID": "IPR033123", "InterPro-Name": "GH11_dom", "InterPro-Type": "DOMAIN", "Beg": 34, "End": 223 }, { "InterPro-ID": "IPR033119", "InterPro-Name": "GH11_AS_2", "InterPro-Type": "ACTIVE_SITE", "Beg": 207, "End": 218 }, { "InterPro-ID": "IPR018208", "InterPro-Name": "GH11_AS_1", "InterPro-Type": "ACTIVE_SITE", "Beg": 116, "End": 126 }, { "InterPro-ID": "IPR013319", "InterPro-Name": "GH11/12", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 37, "End": 223 }, { "InterPro-ID": "IPR013320", "InterPro-Name": "ConA-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 35, "End": 222 }, { "InterPro-ID": "IPR001137", "InterPro-Name": "Glyco_hydro_11", "InterPro-Type": "FAMILY", "Beg": 1, "End": 223 } ], "response#1": "MVSFTTLLAGFVAVTGVLSAPTETVEVVDVEKRQTIGPGTGFNNGYYYSYWNDGHSGVTYTNGAGGSFSVNWANSGNFVGGKGWNPGSSSRVINFSGSYNPNGNSYLSVYGWSKNPLIEYYIVENFGTYNPSTGTTKLGEVTSDGSVYDIYRTQRVNQPSIIGTATFYQYWSVRRNHAPAARSRLRTTSNAWRNLGLTLGTLDYQIIAVEGYFSSGNANINVS", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more GH11_dom, GH11_dom that are essential for its biological function; 2. The protein should belong to Glyco_hydro_11, Glyco_hydro_11, Glyco_hydro_11, Glyco_hydro_11, Glyco_hydro_11, Glyco_hydro_11, Glyco_hydro_11 that shares evolutionary origin and functional similarity; 3. The protein should be classified within GH11/12, ConA-like_dom_sf sharing conserved structural features; 4. The protein must have GH11_AS_2, GH11_AS_1 that is conserved among related catalytic enzymes. The designed protein sequence is ", "reference": "MVSFTTLLAGFVAVTGVLSAPTETVEVVDVEKRQTIGPGTGFNNGYYYSYWNDGHSGVTYTNGAGGSFSVNWANSGNFVGGKGWNPGSSSRVINFSGSYNPNGNSYLSVYGWSKNPLIEYYIVENFGTYNPSTGTTKLGEVTSDGSVYDIYRTQRVNQPSIIGTATFYQYWSVRRNHAPAARSRLRTTSNAWRNLGLTLGTLDYQIIAVEGYFSSGNANINVS" }, { "InterPro": [ { "InterPro-ID": "IPR005599", "InterPro-Name": "GPI_mannosylTrfase", "InterPro-Type": "FAMILY", "Beg": 78, "End": 589 }, { "InterPro-ID": "IPR005599", "InterPro-Name": "GPI_mannosylTrfase", "InterPro-Type": "FAMILY", "Beg": 76, "End": 498 } ], "response#1": "MAPPAARARYIANKADNQILSKKPPKRPGLNGNNKTKEATPAGKKKDKDAKKRNQPTSGGQEKGLPNPIMPSVQTAFKTFVSARLCSAIWAYIADCDETFNYWEPLHYIINGHGLQTWEYSPQFGLRSYTYLLLQGVPGYFYQKLFNPSPILIFYMVRCMLGFGCAVMERYMYKSICQEFGIHIGRLWLIFQLFSVGMFVSSTALLPSSFSMYFGCAALAAWWQQNYCFAIFLTAISALLGWPFAALIGIPLVLEMLLRQRDWKTFVQWTLISGATVAIPMIAIDTSYFGKLTFAPLNIVWYNVFTSHGPNIFGTEPLSYYIINGFLNFNIIWLLALQLPIMLVIDYLIVPAKSKSTLNFPHYISLAPLYLWLLVFFAQPHKEERFLFPIYPLISLCGAITVDVYQRIFFRMKSVVFKIKAGVHYLDHSMFIAILVMVTSTLLGLSRVFALYRNYHAPMDLMLELNQFKATPQYDPDVIYNVCIGKDWHRYPGSFFFPAKNFRLRFLKSEFRGMLPAYYDEGQNATKVVQPYFNDLNQENEHMYFDYDRCDFLVDFDEGKYTALEPNYSKRSKDWSVMKSLPFLIPEKSHKVLRAFYVPFLTDNHIQYGDFNLLKRKTKRNGR", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to GPI_mannosylTrfase, GPI_mannosylTrfase that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MAPPAARARYIANKADNQILSKKPPKRPGLNGNNKTKEATPAGKKKDKDAKKRNQPTSGGQEKGLPNPIMPSVQTAFKTFVSARLCSAIWAYIADCDETFNYWEPLHYIINGHGLQTWEYSPQFGLRSYTYLLLQGVPGYFYQKLFNPSPILIFYMVRCMLGFGCAVMERYMYKSICQEFGIHIGRLWLIFQLFSVGMFVSSTALLPSSFSMYFGCAALAAWWQQNYCFAIFLTAISALLGWPFAALIGIPLVLEMLLRQRDWKTFVQWTLISGATVAIPMIAIDTSYFGKLTFAPLNIVWYNVFTSHGPNIFGTEPLSYYIINGFLNFNIIWLLALQLPIMLVIDYLIVPAKSKSTLNFPHYISLAPLYLWLLVFFAQPHKEERFLFPIYPLISLCGAITVDVYQRIFFRMKSVVFKIKAGVHYLDHSMFIAILVMVTSTLLGLSRVFALYRNYHAPMDLMLELNQFKATPQYDPDVIYNVCIGKDWHRYPGSFFFPAKNFRLRFLKSEFRGMLPAYYDEGQNATKVVQPYFNDLNQENEHMYFDYDRCDFLVDFDEGKYTALEPNYSKRSKDWSVMKSLPFLIPEKSHKVLRAFYVPFLTDNHIQYGDFNLLKRKTKRNGR" }, { "InterPro": [ { "InterPro-ID": "IPR001680", "InterPro-Name": "WD40_rpt", "InterPro-Type": "REPEAT", "Beg": 493, "End": 524 }, { "InterPro-ID": "IPR037264", "InterPro-Name": "TFIID_NTD2_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 95, "End": 278 }, { "InterPro-ID": "IPR001680", "InterPro-Name": "WD40_rpt", "InterPro-Type": "REPEAT", "Beg": 619, "End": 660 }, { "InterPro-ID": "IPR015943", "InterPro-Name": "WD40/YVTN_repeat-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 342, "End": 572 }, { "InterPro-ID": "IPR020472", "InterPro-Name": "G-protein_beta_WD-40_rep", "InterPro-Type": "REPEAT", "Beg": 554, "End": 568 }, { "InterPro-ID": "IPR020472", "InterPro-Name": "G-protein_beta_WD-40_rep", "InterPro-Type": "REPEAT", "Beg": 680, "End": 694 }, { "InterPro-ID": "IPR020472", "InterPro-Name": "G-protein_beta_WD-40_rep", "InterPro-Type": "REPEAT", "Beg": 596, "End": 610 }, { "InterPro-ID": "IPR015943", "InterPro-Name": "WD40/YVTN_repeat-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 573, "End": 741 }, { "InterPro-ID": "IPR055442", "InterPro-Name": "Beta-prop_EML-like_2nd", "InterPro-Type": "DOMAIN", "Beg": 542, "End": 721 }, { "InterPro-ID": "IPR001680", "InterPro-Name": "WD40_rpt", "InterPro-Type": "REPEAT", "Beg": 661, "End": 702 }, { "InterPro-ID": "IPR001680", "InterPro-Name": "WD40_rpt", "InterPro-Type": "REPEAT", "Beg": 381, "End": 419 }, { "InterPro-ID": "IPR001680", "InterPro-Name": "WD40_rpt", "InterPro-Type": "REPEAT", "Beg": 570, "End": 609 }, { "InterPro-ID": "IPR001680", "InterPro-Name": "WD40_rpt", "InterPro-Type": "REPEAT", "Beg": 528, "End": 567 }, { "InterPro-ID": "IPR001680", "InterPro-Name": "WD40_rpt", "InterPro-Type": "REPEAT", "Beg": 486, "End": 525 }, { "InterPro-ID": "IPR001680", "InterPro-Name": "WD40_rpt", "InterPro-Type": "REPEAT", "Beg": 612, "End": 651 }, { "InterPro-ID": "IPR001680", "InterPro-Name": "WD40_rpt", "InterPro-Type": "REPEAT", "Beg": 654, "End": 693 }, { "InterPro-ID": "IPR037264", "InterPro-Name": "TFIID_NTD2_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 93, "End": 272 }, { "InterPro-ID": "IPR001680", "InterPro-Name": "WD40_rpt", "InterPro-Type": "REPEAT", "Beg": 492, "End": 524 }, { "InterPro-ID": "IPR019775", "InterPro-Name": "WD40_repeat_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 680, "End": 694 }, { "InterPro-ID": "IPR001680", "InterPro-Name": "WD40_rpt", "InterPro-Type": "REPEAT", "Beg": 535, "End": 576 }, { "InterPro-ID": "IPR001680", "InterPro-Name": "WD40_rpt", "InterPro-Type": "REPEAT", "Beg": 577, "End": 618 }, { "InterPro-ID": "IPR036322", "InterPro-Name": "WD40_repeat_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 385, "End": 700 } ], "response#1": "MSLPSASNHAHAASPVYSNSNNNKSSASSKKTSSKNDLLRCAVGLLLKQKNYVSNERFRRSDFLLLQNKQQFAVNKMLDTDLHGGNSFTFSNVQVITNNQHTVDQQFGRFSQFVEAQAEPLRLEMKRFYGPMLCHFYLDLLKAREPRGAVELLRKYAHLVAPVDMYDAPPPTKINGCSTTANESTFNIRFAKEAQDTGDTELDYFMRLVQTLSGYTRLEAAESDDTVAHFRSSKYELHTTAVVVNRICAYLQRRGHVLIMNLLYTWLHVHIVENEQRAFSEDHLLGLTDDLEGEDGEDDVVSKPAVTLNTRGDIRPSKSLTEKSNRKRPAEEPNIMLETDIKQEVETDESAELSKLQLNIDACLDTLKSATEQILKSQVELPRFLRISERSRGLTSAHLDPSECHMLAGFDNSAVQLWQLNQSYCRGKSFYRRYPQKRCPWELNNCANQEEETDEDSSDEDVKCSEEERRERNRARHCKYADNSYNEYGGFQLRGHTKGVTDVRFSAHYPLMYSVSKDATMRCWRAHNLHCAAIYRSHNYPIWCLDESPVGQYVVTGSKDLSARLWSLEKEHALIIYAGHTQDVECVAFHPNGNYIATGSADHSVRLWCATSGKLMRVFADCRQAVTQLAFSPDGKMLAAAGEETKVRIFDLAAGAQLAELKDHSASISSLSWSTHNRHLATACSDGTLRLWDIKKLSPMSDNSSAGSSSSATTNRVLTVNSSCQRLVDVFYGTSKTLYCIGT", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Beta-prop_EML-like_2nd that are essential for its biological function; 2. The protein should be classified within TFIID_NTD2_sf, WD40/YVTN_repeat-like_dom_sf, WD40/YVTN_repeat-like_dom_sf, TFIID_NTD2_sf, WD40_repeat_dom_sf sharing conserved structural features; 3. The protein should include one or more WD40_rpt, WD40_rpt, G-protein_beta_WD-40_rep, G-protein_beta_WD-40_rep, G-protein_beta_WD-40_rep, WD40_rpt, WD40_rpt, WD40_rpt, WD40_rpt, WD40_rpt, WD40_rpt, WD40_rpt, WD40_rpt, WD40_rpt, WD40_rpt that provide structural or functional support; 4. The protein should contain WD40_repeat_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MSLPSASNHAHAASPVYSNSNNNKSSASSKKTSSKNDLLRCAVGLLLKQKNYVSNERFRRSDFLLLQNKQQFAVNKMLDTDLHGGNSFTFSNVQVITNNQHTVDQQFGRFSQFVEAQAEPLRLEMKRFYGPMLCHFYLDLLKAREPRGAVELLRKYAHLVAPVDMYDAPPPTKINGCSTTANESTFNIRFAKEAQDTGDTELDYFMRLVQTLSGYTRLEAAESDDTVAHFRSSKYELHTTAVVVNRICAYLQRRGHVLIMNLLYTWLHVHIVENEQRAFSEDHLLGLTDDLEGEDGEDDVVSKPAVTLNTRGDIRPSKSLTEKSNRKRPAEEPNIMLETDIKQEVETDESAELSKLQLNIDACLDTLKSATEQILKSQVELPRFLRISERSRGLTSAHLDPSECHMLAGFDNSAVQLWQLNQSYCRGKSFYRRYPQKRCPWELNNCANQEEETDEDSSDEDVKCSEEERRERNRARHCKYADNSYNEYGGFQLRGHTKGVTDVRFSAHYPLMYSVSKDATMRCWRAHNLHCAAIYRSHNYPIWCLDESPVGQYVVTGSKDLSARLWSLEKEHALIIYAGHTQDVECVAFHPNGNYIATGSADHSVRLWCATSGKLMRVFADCRQAVTQLAFSPDGKMLAAAGEETKVRIFDLAAGAQLAELKDHSASISSLSWSTHNRHLATACSDGTLRLWDIKKLSPMSDNSSAGSSSSATTNRVLTVNSSCQRLVDVFYGTSKTLYCIGT" }, { "InterPro": [ { "InterPro-ID": "IPR029448", "InterPro-Name": "FANCD2", "InterPro-Type": "FAMILY", "Beg": 92, "End": 1403 }, { "InterPro-ID": "IPR029448", "InterPro-Name": "FANCD2", "InterPro-Type": "FAMILY", "Beg": 1, "End": 1413 }, { "InterPro-ID": "IPR029448", "InterPro-Name": "FANCD2", "InterPro-Type": "FAMILY", "Beg": 1, "End": 1426 } ], "response#1": "MVSKRKLSKIDAAEESSKTDLQSRCPETKRSRISDKRAPSQGGLENEGVFEELLRTSGIILKVGEGQNEIAVDQTAFQKKLRVALEKHPSYPGVVNEFISGLESHIKDRSQFKNCLLPCTPARTEGSRTLVHSYCESLIKLLLGIKILQPAVVTLLLEKIPEFFFDVVGTFGTNFPRLIVNQFKWLDGLLDSQDLVKKLMQMLSVSPVPIQHDIITSLPEILEDSQQNEVARELSCLLKQGRRLTVPILDALSRLDLDAELLAEVRQSAMTIVPSVKLEDLPVVIKFILHNVKAADAVEVISDLRKSLDLSSCVLPLQLLGSQRKLKSQAQASSSMSQVTTSQNCVKLLFDVIKQAVRFQKDVSEAWIKAIENSTSVSDHKVLDLIVLLLIHSTNSKNRKQTEKVLRSKIRLGCMPEQLMQNAFQNHSMVIKDFFPSILSLAQTFLHSAHPAVVSFGSCMYKQAFAVFDSYCQQEVVCALVTHVCSGNETELDISLDVLTDLVILHPSLLLRYATFVKTILDSMQKLNPCQIRKLFYILSTLAFSQRQEGSYIQDDMHMVIRKWLSSSVPNHKQMGIIGAVTMMGSVALKRNEADGGLLERPELSIECDGQLSTLLDLVGFCCEQTPEVLALYYDELANLIEKQKGNLDLQLLDKFGKSLVEDFPNDFVVDLSPTVDGSFLFPVKSLYNLDEDETQGAIAINLLPLVSQSEPGRVADEMSNSRKRVVSPICLSPCFRLLRLYTGEQNNGSLEEIDALLGCPLYLTDLEVEGKLDSLSKQEREFLCSLLFYALNWFREVVNAFCQQQDAEMKGKVLTRLQNITELQNVLGKCLAATPGYVPPPATFDSEAPEGVPSINAGGPVRKKNGKKRKSDSSKACSAERTQADESSDGNQPDTELSELEKSATEKETGNPLAQLQSYRPYFRELDLEVFSVLHCGLLTKSILDTEMHTEASEVVQLGPAELCFLLDDMCWKLEHVLTPGSTRRVPFLKERGNKDVGFSHLCQRSPKEVAVCVVKLLKPLCNHMENMHNYFQTVIPNQGVVDESGLNIQEYQLMSSCYHQLLLAFRLLFAWSGFSQHENSNLLRSALQVLADRLKPGETEFLPLEELISESFQYLLNFQASIPSFQCAFILTQVLMAISEKPMTGWKREKMASLAKQFLCQSWMKPGGDREKGSHFNSALHTLLCVYLEHTDNILKAIEEISSVGVPELINSAKDGCSSTYPTLSRQTFPVFFRVMMAQLESSVKSIPAGKPSDSGEVQLEKLLKWNIAVRNFHILINLVKVFDSRPVLSICLKYGRLFVEAFLKLAMPLLDHSFKKHRDDVQSLLKTLQLSTRQLHHMCGHSKIHQDLGLTNHVPLLKKSLEQFVYRVKAMLAFNHCQEAFWVGVLKNRDLQGEEILSQASAAPEEDSAEGSEEDTADSAAEEPDGTDSDSGGAGR", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to FANCD2, FANCD2, FANCD2 that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MVSKRKLSKIDAAEESSKTDLQSRCPETKRSRISDKRAPSQGGLENEGVFEELLRTSGIILKVGEGQNEIAVDQTAFQKKLRVALEKHPSYPGVVNEFISGLESHIKDRSQFKNCLLPCTPARTEGSRTLVHSYCESLIKLLLGIKILQPAVVTLLLEKIPEFFFDVVGTFGTNFPRLIVNQFKWLDGLLDSQDLVKKLMQMLSVSPVPIQHDIITSLPEILEDSQQNEVARELSCLLKQGRRLTVPILDALSRLDLDAELLAEVRQSAMTIVPSVKLEDLPVVIKFILHNVKAADAVEVISDLRKSLDLSSCVLPLQLLGSQRKLKSQAQASSSMSQVTTSQNCVKLLFDVIKQAVRFQKDVSEAWIKAIENSTSVSDHKVLDLIVLLLIHSTNSKNRKQTEKVLRSKIRLGCMPEQLMQNAFQNHSMVIKDFFPSILSLAQTFLHSAHPAVVSFGSCMYKQAFAVFDSYCQQEVVCALVTHVCSGNETELDISLDVLTDLVILHPSLLLRYATFVKTILDSMQKLNPCQIRKLFYILSTLAFSQRQEGSYIQDDMHMVIRKWLSSSVPNHKQMGIIGAVTMMGSVALKRNEADGGLLERPELSIECDGQLSTLLDLVGFCCEQTPEVLALYYDELANLIEKQKGNLDLQLLDKFGKSLVEDFPNDFVVDLSPTVDGSFLFPVKSLYNLDEDETQGAIAINLLPLVSQSEPGRVADEMSNSRKRVVSPICLSPCFRLLRLYTGEQNNGSLEEIDALLGCPLYLTDLEVEGKLDSLSKQEREFLCSLLFYALNWFREVVNAFCQQQDAEMKGKVLTRLQNITELQNVLGKCLAATPGYVPPPATFDSEAPEGVPSINAGGPVRKKNGKKRKSDSSKACSAERTQADESSDGNQPDTELSELEKSATEKETGNPLAQLQSYRPYFRELDLEVFSVLHCGLLTKSILDTEMHTEASEVVQLGPAELCFLLDDMCWKLEHVLTPGSTRRVPFLKERGNKDVGFSHLCQRSPKEVAVCVVKLLKPLCNHMENMHNYFQTVIPNQGVVDESGLNIQEYQLMSSCYHQLLLAFRLLFAWSGFSQHENSNLLRSALQVLADRLKPGETEFLPLEELISESFQYLLNFQASIPSFQCAFILTQVLMAISEKPMTGWKREKMASLAKQFLCQSWMKPGGDREKGSHFNSALHTLLCVYLEHTDNILKAIEEISSVGVPELINSAKDGCSSTYPTLSRQTFPVFFRVMMAQLESSVKSIPAGKPSDSGEVQLEKLLKWNIAVRNFHILINLVKVFDSRPVLSICLKYGRLFVEAFLKLAMPLLDHSFKKHRDDVQSLLKTLQLSTRQLHHMCGHSKIHQDLGLTNHVPLLKKSLEQFVYRVKAMLAFNHCQEAFWVGVLKNRDLQGEEILSQASAAPEEDSAEGSEEDTADSAAEEPDGTDSDSGGAGR" }, { "InterPro": [ { "InterPro-ID": "IPR009072", "InterPro-Name": "Histone-fold", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 103, "End": 143 }, { "InterPro-ID": "IPR003195", "InterPro-Name": "TFIID_TAF13", "InterPro-Type": "FAMILY", "Beg": 103, "End": 304 }, { "InterPro-ID": "IPR003195", "InterPro-Name": "TFIID_TAF13", "InterPro-Type": "FAMILY", "Beg": 104, "End": 180 }, { "InterPro-ID": "IPR009072", "InterPro-Name": "Histone-fold", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 103, "End": 142 } ], "response#1": "MNYNAKRVMRQNSVCVGSNDMAASPIMIGPAPPSAPSTPQLQTTEDIKPLLVQRQVILLQSGSIPTNPSPQQINLAGHNVAGGASGSNVANVLIPDDAPVSLLTEIADIMRSFGDSDQPRTGSVKLVEQILQQQLRGIFNEASLVAMRRKQNPCPSQADFEFLMRNHPVKIARMRKHLKDMRILKRFLSIRTGRPQDFMDDLEQQEEDEELAIDVYELHDEDRMRRLFRADRISQILTGQQYLEFNEARKTSFYCRHGEKIKNKFRRFLDLPADLRIPTPTMNILAYLAHETIAAIVDYSILTRLNSDNRATEPYSRVTSAGGSPAMMHVCPEVTQGRGMEVVKPISVPEIHEAMRRFRQMSSRKIGRYRNSCDIDFRRSFLAI", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to TFIID_TAF13, TFIID_TAF13 that shares evolutionary origin and functional similarity; 2. The protein should be classified within Histone-fold, Histone-fold sharing conserved structural features. The designed protein sequence is ", "reference": "MNYNAKRVMRQNSVCVGSNDMAASPIMIGPAPPSAPSTPQLQTTEDIKPLLVQRQVILLQSGSIPTNPSPQQINLAGHNVAGGASGSNVANVLIPDDAPVSLLTEIADIMRSFGDSDQPRTGSVKLVEQILQQQLRGIFNEASLVAMRRKQNPCPSQADFEFLMRNHPVKIARMRKHLKDMRILKRFLSIRTGRPQDFMDDLEQQEEDEELAIDVYELHDEDRMRRLFRADRISQILTGQQYLEFNEARKTSFYCRHGEKIKNKFRRFLDLPADLRIPTPTMNILAYLAHETIAAIVDYSILTRLNSDNRATEPYSRVTSAGGSPAMMHVCPEVTQGRGMEVVKPISVPEIHEAMRRFRQMSSRKIGRYRNSCDIDFRRSFLAI" }, { "InterPro": [ { "InterPro-ID": "IPR036249", "InterPro-Name": "Thioredoxin-like_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 3, "End": 177 }, { "InterPro-ID": "IPR024253", "InterPro-Name": "Phosducin_thioredoxin-like_dom", "InterPro-Type": "DOMAIN", "Beg": 29, "End": 163 } ], "response#1": "MANILENQLFTAAKTIEQQLDQQLDRLDNLDSDDLKVLREQRLREMKDLNNKKQEWLRNGHGTYTELADEKEFFEMSKKSPNIVCHFYRDSTERCKIVDMHLKILAAKHVEAKFCKVNAEKTPFLTQRLRIKVIPTIALVKDSKTKDFIVGFTDLGNCDDFATEMLEWRIAHSGAIDYKGDLMQPPDVKRKPFINRPQKTIRGGYDSDDSDIDLDD", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Phosducin_thioredoxin-like_dom that are essential for its biological function; 2. The protein should be classified within Thioredoxin-like_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MANILENQLFTAAKTIEQQLDQQLDRLDNLDSDDLKVLREQRLREMKDLNNKKQEWLRNGHGTYTELADEKEFFEMSKKSPNIVCHFYRDSTERCKIVDMHLKILAAKHVEAKFCKVNAEKTPFLTQRLRIKVIPTIALVKDSKTKDFIVGFTDLGNCDDFATEMLEWRIAHSGAIDYKGDLMQPPDVKRKPFINRPQKTIRGGYDSDDSDIDLDD" }, { "InterPro": [ { "InterPro-ID": "IPR000719", "InterPro-Name": "Prot_kinase_dom", "InterPro-Type": "DOMAIN", "Beg": 410, "End": 597 }, { "InterPro-ID": "IPR000719", "InterPro-Name": "Prot_kinase_dom", "InterPro-Type": "DOMAIN", "Beg": 147, "End": 299 }, { "InterPro-ID": "IPR011009", "InterPro-Name": "Kinase-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 134, "End": 602 }, { "InterPro-ID": "IPR017441", "InterPro-Name": "Protein_kinase_ATP_BS", "InterPro-Type": "BINDING_SITE", "Beg": 151, "End": 181 }, { "InterPro-ID": "IPR000719", "InterPro-Name": "Prot_kinase_dom", "InterPro-Type": "DOMAIN", "Beg": 145, "End": 597 }, { "InterPro-ID": "IPR008271", "InterPro-Name": "Ser/Thr_kinase_AS", "InterPro-Type": "ACTIVE_SITE", "Beg": 264, "End": 276 } ], "response#1": "MDKKEVQHHRSQQAMTKSLYAIGMGLLGKSATNMDCANTNLESAGKSSSTNYNRNRFYNERFVPMASGTMPSVSGTNHHSRHQQLLLQQAPKCTADLNEKLVKINRQNANKELSTIQAKDMQSVDKNEEALKELQESIPEINKIFDVHCRIGSGTFSTVLLGTLQRERGLVETQRRRFAIKHHNPTNHPERILRELECMYRIGGVENVIGINCCIRYNDNVAFIMPYMTHDRFHDIYRSLNFPEIRDYLRNLLIALRHVHKFNVIHRDVKPSNILYNRRTGKFLLCDFGLAQRIADDGSVVQSSDLSSREVFSILRDLENGRSVTLTDGNSAQAEAEDYMARRRMRALGGGGSVERAVTGPPSIQKLREQAGGHLTKKDVANQRADTMRLLNRLRLVSPNADPNNYVVSTNTSKKEMHASRAGTPGYRPPEVLLRYPKQSTAVDVWAAGVIMLSLLSGLHPFFKAPHDCGALAEIINLFGDMPVRKTAFLLDRLILLAQKVNTLDLRRVCMRFRHADFFLAPEIQRKYQRPDGTTEMCRSCEQPTFNCLCSNSGHNLERYDGLDIFPAVAYDLLSRLLEVNPQKRITAEEALKHPFFSDQHRITPGIPLHQQQLIMHQQQHIMQHQQHLQRSRETLPSSAARTLKAFVCYPMEITSTASQAAGNI", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Prot_kinase_dom, Prot_kinase_dom, Prot_kinase_dom that are essential for its biological function; 2. The protein should be classified within Kinase-like_dom_sf sharing conserved structural features; 3. The protein must have Ser/Thr_kinase_AS that is conserved among related catalytic enzymes; 4. The protein should include a Protein_kinase_ATP_BS that enables ligand binding under diverse conditions. The designed protein sequence is ", "reference": "MDKKEVQHHRSQQAMTKSLYAIGMGLLGKSATNMDCANTNLESAGKSSSTNYNRNRFYNERFVPMASGTMPSVSGTNHHSRHQQLLLQQAPKCTADLNEKLVKINRQNANKELSTIQAKDMQSVDKNEEALKELQESIPEINKIFDVHCRIGSGTFSTVLLGTLQRERGLVETQRRRFAIKHHNPTNHPERILRELECMYRIGGVENVIGINCCIRYNDNVAFIMPYMTHDRFHDIYRSLNFPEIRDYLRNLLIALRHVHKFNVIHRDVKPSNILYNRRTGKFLLCDFGLAQRIADDGSVVQSSDLSSREVFSILRDLENGRSVTLTDGNSAQAEAEDYMARRRMRALGGGGSVERAVTGPPSIQKLREQAGGHLTKKDVANQRADTMRLLNRLRLVSPNADPNNYVVSTNTSKKEMHASRAGTPGYRPPEVLLRYPKQSTAVDVWAAGVIMLSLLSGLHPFFKAPHDCGALAEIINLFGDMPVRKTAFLLDRLILLAQKVNTLDLRRVCMRFRHADFFLAPEIQRKYQRPDGTTEMCRSCEQPTFNCLCSNSGHNLERYDGLDIFPAVAYDLLSRLLEVNPQKRITAEEALKHPFFSDQHRITPGIPLHQQQLIMHQQQHIMQHQQHLQRSRETLPSSAARTLKAFVCYPMEITSTASQAAGNI" }, { "InterPro": [ { "InterPro-ID": "IPR053109", "InterPro-Name": "Ser/Thr-Kinase-Related", "InterPro-Type": "FAMILY", "Beg": 30, "End": 927 } ], "response#1": "MPLNDVAPAGGGAYPENGTKHKVSGMWKPDSSAGSNSGSGSAGLSLFSLQGQKWQQVFDMEKVIKQLRTAEKTYLRGGKNSSAGADQQAKVQVQRLQSADMAYYDLAPKLASRDIVLCSSCSGCYTKAGFQHHIALQHPSVWEATSSKVNPNPNGTAISSDSRLTATEISQEGGAIVPSSPTDTLSASTLSSCSNGSSSSASLQHPAAAGSSSTTSSSSSSRHKSSSSKSSSSSSSKGSSSTSAGSRSRSKSSKNRHHSSPAPALLESNHKESKGSKKSSAIAAPPVVAAVVKEEPPSVGAAPAAITMFSSSSNSSCSLPPTPTLGAASSEVAMGVNYSPAQLQTDAEKLPELQPKKKLKGSSDHRIKAEKEKNKDKSLVNSYEQQQVLSELDQAVSSITGAVSAEQVAPDEEELPLPNTSDENSISQTLDEMLDSKLINEILNNFDESALDTSQQQSQQQAQNGSLSHPAQATKRLRFEDGTIGEDYAVYQQQAVQQVYGEEEHQQELTTIDAMQLQQLIYQQQQMLEQQQLQEQQQQQQQDQKLQDHEQQRQFSVYNVPSLTDEAMVNPQQQQLEEHMILPSIIYEITESNPVSMLEQKVLAEFLTNAGYENVDVNVVQSGGIQTNLSSGTEANQLADELADFEFSKLETVSDTVKTVKLEAKAASQPPTTNPQINHHPSLANAKYHEDSYFNVMLYSGAPRPLAMNTFGMVKLPQGLGVTFRKNLLTTRKANNNLLSLSGGNHLGVVGQLARTPPPPSPALSNGLPGKNPASGRTIYAQRSNVIAQDRLRCNKRALVGGKAGGGSSGSPGVMTAKRLNELLMGKAKKEEKPPPDSEDGGEQPTKDKERDKEEDNKLTFSFYEKRRRLLAGKLEQLQPLGRPSFTLPLQSNHNASQSQSHSPQQLLKKQLLRTLSDSSSNMNISNMNNISNLNSSNTPSANSNPPWKGNSSNPGGNSTPTSSDLMRVFV", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Ser/Thr-Kinase-Related that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MPLNDVAPAGGGAYPENGTKHKVSGMWKPDSSAGSNSGSGSAGLSLFSLQGQKWQQVFDMEKVIKQLRTAEKTYLRGGKNSSAGADQQAKVQVQRLQSADMAYYDLAPKLASRDIVLCSSCSGCYTKAGFQHHIALQHPSVWEATSSKVNPNPNGTAISSDSRLTATEISQEGGAIVPSSPTDTLSASTLSSCSNGSSSSASLQHPAAAGSSSTTSSSSSSRHKSSSSKSSSSSSSKGSSSTSAGSRSRSKSSKNRHHSSPAPALLESNHKESKGSKKSSAIAAPPVVAAVVKEEPPSVGAAPAAITMFSSSSNSSCSLPPTPTLGAASSEVAMGVNYSPAQLQTDAEKLPELQPKKKLKGSSDHRIKAEKEKNKDKSLVNSYEQQQVLSELDQAVSSITGAVSAEQVAPDEEELPLPNTSDENSISQTLDEMLDSKLINEILNNFDESALDTSQQQSQQQAQNGSLSHPAQATKRLRFEDGTIGEDYAVYQQQAVQQVYGEEEHQQELTTIDAMQLQQLIYQQQQMLEQQQLQEQQQQQQQDQKLQDHEQQRQFSVYNVPSLTDEAMVNPQQQQLEEHMILPSIIYEITESNPVSMLEQKVLAEFLTNAGYENVDVNVVQSGGIQTNLSSGTEANQLADELADFEFSKLETVSDTVKTVKLEAKAASQPPTTNPQINHHPSLANAKYHEDSYFNVMLYSGAPRPLAMNTFGMVKLPQGLGVTFRKNLLTTRKANNNLLSLSGGNHLGVVGQLARTPPPPSPALSNGLPGKNPASGRTIYAQRSNVIAQDRLRCNKRALVGGKAGGGSSGSPGVMTAKRLNELLMGKAKKEEKPPPDSEDGGEQPTKDKERDKEEDNKLTFSFYEKRRRLLAGKLEQLQPLGRPSFTLPLQSNHNASQSQSHSPQQLLKKQLLRTLSDSSSNMNISNMNNISNLNSSNTPSANSNPPWKGNSSNPGGNSTPTSSDLMRVFV" }, { "InterPro": [ { "InterPro-ID": "IPR021950", "InterPro-Name": "Spt20", "InterPro-Type": "FAMILY", "Beg": 998, "End": 1803 }, { "InterPro-ID": "IPR046468", "InterPro-Name": "Spt20-like_SEP", "InterPro-Type": "DOMAIN", "Beg": 344, "End": 564 } ], "response#1": "MQSLDSSCQEADFIINDTLKKLKGSSNADHVQGLAVHAHGSGVHQTQFVQYGTSGSSPQLQPQQSYHQLHPTLQQQQFASSSSKSYLETSLLQAIPQIPAQPPICIFDDDESPTEGTGGSLGSLLTEPTSATPSGLPTAIAPSPSSCSSSTTTMSNFNSITSPSPVVPDLLLSTPPGVNSSLSNSSTGAASVSSKKSEKRPPSANSTASGGGHHLHHHHLHQTHNHHVLASPTSSPSKRQKSNSSSKESSSSSRSSAIPAASVSTATSSSQSARAGAGAASSNSNSKPPSSVCQSGNSKFFNLHEKIRDLYLQLLSNDLNYFAETGLKQRTRSFTLERLVDREKLNTIVVNLYPGNKGYSLALHYDEHMVLNPQTNEWSPTDKDETSSDAAGLGTGTGSHRSRPKPLAQDESQSKTEAGHAKHDFGLVEVLRWPYENDLLLQCIDREMLPEFLMDLLVAETVSLSDGEGTRVYAKPSVFYAGCVIAQIRDFRQTFATSTNICDMKHILLRPTNATLFAEVQQMGSQLPAEDKLALESQLVLATAEPLCLEPDPSIGRQAINSQHQRQLYNSHELRRQMKKFTQTAINRKRKLDQFTHHHGLELCDYLARLRQRPRTGSSSGGANATPATAPTNNPLVGAMLSSFTSKVPRRPHEVIRPIRPPTLEYPANLKVPEHVISVEKYAKAYEPLNEFSEACKDGCQPNCRHNFQPQLVEEYILETEREASEGRRALYHIKLSIFQRPSDAEYLGELYVDRDYREGERNGESCRFALGTRVHANRYIQQFREIFTEEGRKAVKITHLIPGHMPIVTHTGLTNEQRILLQQQQQQQQRQAQMQQQQQQQQQQVVVVANQQQQSQQQQQTQQAGQQLSATVHHVALPRQQITQKTLNLAGSNVINVQQNFRQQSAQQQQPQTYTIEAPQQQAAAQIVPQQQQQQQQQQQQHIHLQQLATGSSNTSTTTHQVSLSNGSLVLVQQQQPQQQSQQLAQALQHSGITIQPATIQQQQQQVKGTSVVGANSALRAQLNSNVPILQTQLKVQQQQIMQKQQQQQTTATSNNNNNNNNNNNMNNNTAIHPNPAINAIVNSIMNSANQYQQQQQQQHQQQHQQQTGNTSSNNNAAGSGGSTNNNGSSTSATTLKNSSNASILNLLNSAPAAMTSTPVASGTFTTSTGQQQPQTLTLVQHQQQSTPNTADAATATYVQTTRGTPTLVSTQRKQQSSEVLQNLLNANRKIGGGGTTTTTFRTNSAGNLIAVNLNQAGQSHHQQTGDGSQTVRVSMSALASQLASPPAVMTNPTTSYTVISSGNSAAAAAAWIQSPTGPVQQRILSSLRRDSTTAPPNAIVVGMAAPSPGSDSNASNASGFAVPNNLASTSSGGGGGGGALSALLTNAATPSPSGSDHSQSSQTHQNQALLERLSNVTSNVSAVSMPHMSPQQPQPTQQFITKTIVHSPATSSIHSPMSSPHPQPSASPQQQQQQQQQQTTATLNLQGINLSQLQGAMANFAGLQNVQVQIPGFTQPISLQFSGNSLQQQQSGNTATGAGTAQGQQRSVLVSVPVSSQQQQLPHTITLQTQSAPHHQQQHQQTQQQHAPPTGTIVSLPSSGPGTQTVVITNNSGGGVTAGSSTSGSAGGGGGSGATTAMLTLPIAQIVGAGVQKLNPQTIRTSNVGGGIGIAQQTVQQQTIQSQSGGNSTAAIQLLGTIQPRARNVQVVGTKQLANRQLITTQRQIGGSTLKIATTPVNAANVVTSSANLTTTPIVMSAQKLQLKTVKAPVQQQQQPQQQQQQLQQQHRILNQQSTATVSSQTLPSPNQVQVAQQQQQQQQQLQHIQIAGRATTASGAISQRTLTALAAAKQQQQQQQAAVNRRRSTTDATK", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Spt20-like_SEP that are essential for its biological function; 2. The protein should belong to Spt20 that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MQSLDSSCQEADFIINDTLKKLKGSSNADHVQGLAVHAHGSGVHQTQFVQYGTSGSSPQLQPQQSYHQLHPTLQQQQFASSSSKSYLETSLLQAIPQIPAQPPICIFDDDESPTEGTGGSLGSLLTEPTSATPSGLPTAIAPSPSSCSSSTTTMSNFNSITSPSPVVPDLLLSTPPGVNSSLSNSSTGAASVSSKKSEKRPPSANSTASGGGHHLHHHHLHQTHNHHVLASPTSSPSKRQKSNSSSKESSSSSRSSAIPAASVSTATSSSQSARAGAGAASSNSNSKPPSSVCQSGNSKFFNLHEKIRDLYLQLLSNDLNYFAETGLKQRTRSFTLERLVDREKLNTIVVNLYPGNKGYSLALHYDEHMVLNPQTNEWSPTDKDETSSDAAGLGTGTGSHRSRPKPLAQDESQSKTEAGHAKHDFGLVEVLRWPYENDLLLQCIDREMLPEFLMDLLVAETVSLSDGEGTRVYAKPSVFYAGCVIAQIRDFRQTFATSTNICDMKHILLRPTNATLFAEVQQMGSQLPAEDKLALESQLVLATAEPLCLEPDPSIGRQAINSQHQRQLYNSHELRRQMKKFTQTAINRKRKLDQFTHHHGLELCDYLARLRQRPRTGSSSGGANATPATAPTNNPLVGAMLSSFTSKVPRRPHEVIRPIRPPTLEYPANLKVPEHVISVEKYAKAYEPLNEFSEACKDGCQPNCRHNFQPQLVEEYILETEREASEGRRALYHIKLSIFQRPSDAEYLGELYVDRDYREGERNGESCRFALGTRVHANRYIQQFREIFTEEGRKAVKITHLIPGHMPIVTHTGLTNEQRILLQQQQQQQQRQAQMQQQQQQQQQQVVVVANQQQQSQQQQQTQQAGQQLSATVHHVALPRQQITQKTLNLAGSNVINVQQNFRQQSAQQQQPQTYTIEAPQQQAAAQIVPQQQQQQQQQQQQHIHLQQLATGSSNTSTTTHQVSLSNGSLVLVQQQQPQQQSQQLAQALQHSGITIQPATIQQQQQQVKGTSVVGANSALRAQLNSNVPILQTQLKVQQQQIMQKQQQQQTTATSNNNNNNNNNNNMNNNTAIHPNPAINAIVNSIMNSANQYQQQQQQQHQQQHQQQTGNTSSNNNAAGSGGSTNNNGSSTSATTLKNSSNASILNLLNSAPAAMTSTPVASGTFTTSTGQQQPQTLTLVQHQQQSTPNTADAATATYVQTTRGTPTLVSTQRKQQSSEVLQNLLNANRKIGGGGTTTTTFRTNSAGNLIAVNLNQAGQSHHQQTGDGSQTVRVSMSALASQLASPPAVMTNPTTSYTVISSGNSAAAAAAWIQSPTGPVQQRILSSLRRDSTTAPPNAIVVGMAAPSPGSDSNASNASGFAVPNNLASTSSGGGGGGGALSALLTNAATPSPSGSDHSQSSQTHQNQALLERLSNVTSNVSAVSMPHMSPQQPQPTQQFITKTIVHSPATSSIHSPMSSPHPQPSASPQQQQQQQQQQTTATLNLQGINLSQLQGAMANFAGLQNVQVQIPGFTQPISLQFSGNSLQQQQSGNTATGAGTAQGQQRSVLVSVPVSSQQQQLPHTITLQTQSAPHHQQQHQQTQQQHAPPTGTIVSLPSSGPGTQTVVITNNSGGGVTAGSSTSGSAGGGGGSGATTAMLTLPIAQIVGAGVQKLNPQTIRTSNVGGGIGIAQQTVQQQTIQSQSGGNSTAAIQLLGTIQPRARNVQVVGTKQLANRQLITTQRQIGGSTLKIATTPVNAANVVTSSANLTTTPIVMSAQKLQLKTVKAPVQQQQQPQQQQQQLQQQHRILNQQSTATVSSQTLPSPNQVQVAQQQQQQQQQLQHIQIAGRATTASGAISQRTLTALAAAKQQQQQQQAAVNRRRSTTDATK" }, { "InterPro": [ { "InterPro-ID": "IPR032395", "InterPro-Name": "Phage_tail_NK", "InterPro-Type": "DOMAIN", "Beg": 108, "End": 282 }, { "InterPro-ID": "IPR038681", "InterPro-Name": "Phage_tail_NK_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 127, "End": 282 } ], "response#1": "MADSNLNVPVIIQATRLDTSVLPRNIFSQSYLLYVIAQGTDVGNVANKANEAGQGAYDAQVRNDEQDVILADHEQRISAAEATLVNHEERIRQAESTLQDHETRIAQNESDISSLDTRVQSLESQVSDHETRIDALEYATTRKKSEVVYSGVSVTIPTAPTNLVSLLKTLTPSSGTLAPFFDTVNNKMVVFNENKTLFFKLSIVGTWPSGTANRSMQLTFSGSVPDTLVSSRNSATTTDNILLATFFSVDKDGFLATNGSTLTIQSNGASFTATTIKIIAEQ", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Phage_tail_NK that are essential for its biological function; 2. The protein should be classified within Phage_tail_NK_sf sharing conserved structural features. The designed protein sequence is ", "reference": "MADSNLNVPVIIQATRLDTSVLPRNIFSQSYLLYVIAQGTDVGNVANKANEAGQGAYDAQVRNDEQDVILADHEQRISAAEATLVNHEERIRQAESTLQDHETRIAQNESDISSLDTRVQSLESQVSDHETRIDALEYATTRKKSEVVYSGVSVTIPTAPTNLVSLLKTLTPSSGTLAPFFDTVNNKMVVFNENKTLFFKLSIVGTWPSGTANRSMQLTFSGSVPDTLVSSRNSATTTDNILLATFFSVDKDGFLATNGSTLTIQSNGASFTATTIKIIAEQ" }, { "InterPro": [ { "InterPro-ID": "IPR037802", "InterPro-Name": "SGF29", "InterPro-Type": "FAMILY", "Beg": 7, "End": 274 }, { "InterPro-ID": "IPR010750", "InterPro-Name": "SGF29_tudor-like_dom", "InterPro-Type": "DOMAIN", "Beg": 137, "End": 278 }, { "InterPro-ID": "IPR047287", "InterPro-Name": "Tudor_SGF29_rpt2", "InterPro-Type": "DOMAIN", "Beg": 213, "End": 272 }, { "InterPro-ID": "IPR047288", "InterPro-Name": "Tudor_SGF29_rpt1", "InterPro-Type": "DOMAIN", "Beg": 139, "End": 202 }, { "InterPro-ID": "IPR010750", "InterPro-Name": "SGF29_tudor-like_dom", "InterPro-Type": "DOMAIN", "Beg": 144, "End": 272 } ], "response#1": "MPLTAESAAQQIQDRLKDIQQNIHNVDEERRRAENSIASLVRSLHATNQKVKPLLKASLTEAAQEEATIRAALAKIHEIRSIRNERRIQARNAGNKEAIRRGALMKMVQLSAQTLPLFVGKLGERAPALCGAIPAEGNYVAKVGDNVAALAKGIDEEENWILAEVVQFLHRQNKYDVIDIDEEQKDRHVLSKRKVIPLPLMRANPETDGHALFPKDTVVMALYPQTTCFYKAIVHRLPQTATEDYEVLFEDSSYTNGYAEPLPVAQRYVIAYRPTKKGAGSGSGNLSSA", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more SGF29_tudor-like_dom, Tudor_SGF29_rpt2, Tudor_SGF29_rpt1, SGF29_tudor-like_dom that are essential for its biological function; 2. The protein should belong to SGF29 that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MPLTAESAAQQIQDRLKDIQQNIHNVDEERRRAENSIASLVRSLHATNQKVKPLLKASLTEAAQEEATIRAALAKIHEIRSIRNERRIQARNAGNKEAIRRGALMKMVQLSAQTLPLFVGKLGERAPALCGAIPAEGNYVAKVGDNVAALAKGIDEEENWILAEVVQFLHRQNKYDVIDIDEEQKDRHVLSKRKVIPLPLMRANPETDGHALFPKDTVVMALYPQTTCFYKAIVHRLPQTATEDYEVLFEDSSYTNGYAEPLPVAQRYVIAYRPTKKGAGSGSGNLSSA" }, { "InterPro": [ { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 35, "End": 128 }, { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 35, "End": 130 } ], "response#1": "MKFIGLATLSLFALASADKFPVPDSITVAEGSSKCGDQAQLSCCNDVKYGGDTTVVQKGIAAGLLSDLLGAGSAAEGLGAFSGCSKLDISLLIGIEDILNQKCKQNIACCAKSGGSADGDLVGATLPCIALGSIL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Hydrophobin, Hydrophobin that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MKFIGLATLSLFALASADKFPVPDSITVAEGSSKCGDQAQLSCCNDVKYGGDTTVVQKGIAAGLLSDLLGAGSAAEGLGAFSGCSKLDISLLIGIEDILNQKCKQNIACCAKSGGSADGDLVGATLPCIALGSIL" }, { "InterPro": [ { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 43, "End": 125 } ], "response#1": "MQFTIASLIATAVLGLQMASAAPHAPGSSNAAIISQAQEQNTCGNAHLSCCESTDNSVSLTQEEEEGLLHLLGGTSSVLSDGLLGKYSGCSSLASVEGILGAGGNQGLVSGQCNNHVACCDAGDNELVGFLEPGVAVLKPNSDGIQNGLANVAVPCVPVQVL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Hydrophobin that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MQFTIASLIATAVLGLQMASAAPHAPGSSNAAIISQAQEQNTCGNAHLSCCESTDNSVSLTQEEEEGLLHLLGGTSSVLSDGLLGKYSGCSSLASVEGILGAGGNQGLVSGQCNNHVACCDAGDNELVGFLEPGVAVLKPNSDGIQNGLANVAVPCVPVQVL" }, { "InterPro": [ { "InterPro-ID": "IPR019778", "InterPro-Name": "Hydrophobin_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 78, "End": 89 }, { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 28, "End": 104 }, { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 28, "End": 101 } ], "response#1": "MFFQTTIVAALAFLAVATPLALRTDSRCNTESVKCCNKSEDAETFKKSASAALIPIKIGDITGKVYSECSPIVGLIGGSSCSAQTVCCDNAKFNGLVNIGCTPINVAL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Hydrophobin, Hydrophobin that shares evolutionary origin and functional similarity; 2. The protein should contain Hydrophobin_CS that is preserved across related proteins. The designed protein sequence is ", "reference": "MFFQTTIVAALAFLAVATPLALRTDSRCNTESVKCCNKSEDAETFKKSASAALIPIKIGDITGKVYSECSPIVGLIGGSSCSAQTVCCDNAKFNGLVNIGCTPINVAL" }, { "InterPro": [ { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 36, "End": 105 } ], "response#1": "MKVATALSVLAVAGSALASALPSAANSEKRQSDCIGPLLCCGSLTTPLDPLVDPILELVGIDAAAIVGSVGLLCHAYDDTCTSEPQCCTEANLLGGTLGLGCGPLEHGH", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Hydrophobin that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MKVATALSVLAVAGSALASALPSAANSEKRQSDCIGPLLCCGSLTTPLDPLVDPILELVGIDAAAIVGSVGLLCHAYDDTCTSEPQCCTEANLLGGTLGLGCGPLEHGH" }, { "InterPro": [ { "InterPro-ID": "IPR000801", "InterPro-Name": "Esterase-like", "InterPro-Type": "FAMILY", "Beg": 46, "End": 200 }, { "InterPro-ID": "IPR029058", "InterPro-Name": "AB_hydrolase_fold", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 23, "End": 298 }, { "InterPro-ID": "IPR029058", "InterPro-Name": "AB_hydrolase_fold", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 15, "End": 301 }, { "InterPro-ID": "IPR052558", "InterPro-Name": "Siderophore_Hydrolase_D", "InterPro-Type": "FAMILY", "Beg": 6, "End": 299 } ], "response#1": "MTHWAFSPIQPGAARNMAAWQIAGKKDGPYQIDVSWPLTWSESGDASGKSANAVYLVDGNALFLTATETLRRRESHRPSETGTVVIAIGYPITDSVFSPRRSYDLTPPCDHYIPPEGPDGSPKPEAHGGADEFLTFIAEIVRPFVELKVFPRVSFGRTALFGHSYGGLFALHALFTKPSSFDVYLAASPSIWWNNRSILTEARRFISGAALFSSAHPVLRLSFGSREQYPVRQRVESDEMFKRRQRAAEQRRMNDNCEELYSELLASGRLCKLEVKEYLDEDHGSVIGPALSGGIMFLSNLSA", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Esterase-like, Siderophore_Hydrolase_D that shares evolutionary origin and functional similarity; 2. The protein should be classified within AB_hydrolase_fold, AB_hydrolase_fold sharing conserved structural features. The designed protein sequence is ", "reference": "MTHWAFSPIQPGAARNMAAWQIAGKKDGPYQIDVSWPLTWSESGDASGKSANAVYLVDGNALFLTATETLRRRESHRPSETGTVVIAIGYPITDSVFSPRRSYDLTPPCDHYIPPEGPDGSPKPEAHGGADEFLTFIAEIVRPFVELKVFPRVSFGRTALFGHSYGGLFALHALFTKPSSFDVYLAASPSIWWNNRSILTEARRFISGAALFSSAHPVLRLSFGSREQYPVRQRVESDEMFKRRQRAAEQRRMNDNCEELYSELLASGRLCKLEVKEYLDEDHGSVIGPALSGGIMFLSNLSA" }, { "InterPro": [ { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 59, "End": 124 } ], "response#1": "MKPSIVTFLMLAAVTAAVSAEDPTMSALKSRVEEIAGQVHGVEDQETTPDLSHCVEPKLCCGSLTTPLDPILDPILLSLGINAAQIVGSVGLLCHPWTEECSSAPQCCTEANLLGGTLALGCSKL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Hydrophobin that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MKPSIVTFLMLAAVTAAVSAEDPTMSALKSRVEEIAGQVHGVEDQETTPDLSHCVEPKLCCGSLTTPLDPILDPILLSLGINAAQIVGSVGLLCHPWTEECSSAPQCCTEANLLGGTLALGCSKL" }, { "InterPro": [ { "InterPro-ID": "IPR004302", "InterPro-Name": "Cellulose/chitin-bd_N", "InterPro-Type": "DOMAIN", "Beg": 55, "End": 157 } ], "response#1": "MMLSKVVMGLLTASLAAAHMEMSWPYPLRSRFDPQVPEEDIDYSMTSPLNSDGSNFPCKGYQTNTPWRATAQYTAGQTYNMTITGSATHGGGSCQLSLSYDNGKTFKVIQSMEGGCPLVSKYNFKIPGDVANGQALFAWTWYNLIGNRELYMNCADVVISGGTGTPSSFESAYPDLFVANVGNGCSTVEGRETVFANPGDQVIYGGTVTPSSPAFPICH", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Cellulose/chitin-bd_N that are essential for its biological function. The designed protein sequence is ", "reference": "MMLSKVVMGLLTASLAAAHMEMSWPYPLRSRFDPQVPEEDIDYSMTSPLNSDGSNFPCKGYQTNTPWRATAQYTAGQTYNMTITGSATHGGGSCQLSLSYDNGKTFKVIQSMEGGCPLVSKYNFKIPGDVANGQALFAWTWYNLIGNRELYMNCADVVISGGTGTPSSFESAYPDLFVANVGNGCSTVEGRETVFANPGDQVIYGGTVTPSSPAFPICH" }, { "InterPro": [ { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 59, "End": 132 } ], "response#1": "MRPITILCTLATLSTTLAVPFSQASKSTSASRSTSSSTVPASLPSPTLSGPNACPPNKFKQCCTTLSQVGDDLLKPLGAVVPLVGAIQVNSLVGVSCRPMADAAPESTCGNAVMCCDSSTVGGDDLMQTSCQDFALAKKREREAIERQQRRFSEYQRMMLSQSATPAPTSTGVDVMGSSFSKAKATPTRV", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Hydrophobin that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MRPITILCTLATLSTTLAVPFSQASKSTSASRSTSSSTVPASLPSPTLSGPNACPPNKFKQCCTTLSQVGDDLLKPLGAVVPLVGAIQVNSLVGVSCRPMADAAPESTCGNAVMCCDSSTVGGDDLMQTSCQDFALAKKREREAIERQQRRFSEYQRMMLSQSATPAPTSTGVDVMGSSFSKAKATPTRV" }, { "InterPro": [ { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 52, "End": 143 }, { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 52, "End": 140 } ], "response#1": "MHPRPEHLSPTLNHNHRLKLKQPATTSRMLARTILATLVSAACFATVNAQTCSATNAVCCQQLQDPDNLNADALNLLRLLNINPNTLTGAVGLTCKRLTEACFACLLLTRPGTSLVSGSCNANAACCTGNNYNGLIVLGCTQIQV", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Hydrophobin, Hydrophobin that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MHPRPEHLSPTLNHNHRLKLKQPATTSRMLARTILATLVSAACFATVNAQTCSATNAVCCQQLQDPDNLNADALNLLRLLNINPNTLTGAVGLTCKRLTEACFACLLLTRPGTSLVSGSCNANAACCTGNNYNGLIVLGCTQIQV" }, { "InterPro": [ { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 52, "End": 150 }, { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 52, "End": 148 } ], "response#1": "MLVTMRLSRSIAVFTLVTYATGLPSLQVIPRGEPQLPLLDPSMTIKEAARKCGDKAQLSCCNRVVKAGDYTSVDEGIGAGLLSNLAGGGSGISSILAFDQCSRLDAQVPVVLLPIQDLLNQHCKQNVACCQKNPGDASSSGVGVSLPCIALGSVA", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Hydrophobin, Hydrophobin that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MLVTMRLSRSIAVFTLVTYATGLPSLQVIPRGEPQLPLLDPSMTIKEAARKCGDKAQLSCCNRVVKAGDYTSVDEGIGAGLLSNLAGGGSGISSILAFDQCSRLDAQVPVVLLPIQDLLNQHCKQNVACCQKNPGDASSSGVGVSLPCIALGSVA" }, { "InterPro": [ { "InterPro-ID": "IPR000719", "InterPro-Name": "Prot_kinase_dom", "InterPro-Type": "DOMAIN", "Beg": 350, "End": 504 }, { "InterPro-ID": "IPR000719", "InterPro-Name": "Prot_kinase_dom", "InterPro-Type": "DOMAIN", "Beg": 132, "End": 264 }, { "InterPro-ID": "IPR003527", "InterPro-Name": "MAP_kinase_CS", "InterPro-Type": "CONSERVED_SITE", "Beg": 146, "End": 248 }, { "InterPro-ID": "IPR050117", "InterPro-Name": "MAP_kinase", "InterPro-Type": "FAMILY", "Beg": 77, "End": 525 }, { "InterPro-ID": "IPR000719", "InterPro-Name": "Prot_kinase_dom", "InterPro-Type": "DOMAIN", "Beg": 77, "End": 504 }, { "InterPro-ID": "IPR008271", "InterPro-Name": "Ser/Thr_kinase_AS", "InterPro-Type": "ACTIVE_SITE", "Beg": 232, "End": 244 }, { "InterPro-ID": "IPR011009", "InterPro-Name": "Kinase-like_dom_sf", "InterPro-Type": "HOMOLOGOUS_SUPERFAMILY", "Beg": 72, "End": 510 } ], "response#1": "MSQSTSAGGSQAVAQNPGAKLGFSMRSASIASDSVPCESGLCEAPPGVLSGAGTVFCESTYKVKIDNETVWQVPTRLKFVKKVGSGAYGCVASFEDTSASASEEGTEDDPSRREQSGETRTSQTGSAEGDSGTNKKVAVKKIGDLFRDLIDAKRIYREIKILKELKHENIINLVEILDPLTPDFEDIYLVSDLMDTDLHRVIYSRQPLTPEHHQYFLYQLLLGLSFLHQADIIHRDLKPSNILVNLNCDIKICDFGLARGLNMNPAPPPNLLPPATHRAGPAAAQDVVCTYTPPDNLSGAGKWGDQKLAAAAGAGSIAATRLVRLAHQQGSSLIGAQHQVPAKTDDASDDMELTDYVVTRWYRPPEILISPFCYSKPVDLWSVGCIFAELLGRRALFAGKDHFDQLRRIVRVLGRPSTAEINKVANEGRGRHFNNPSKGTSNTKRKRSEAARRFIESLPNSDPYKLEDLFPDASKAALDLLSNLLTFDPAKRITVQEALRHEYFEGLHSVEDEPTVTTPVNWSFDNFVPTKRLLQNKVYQEIISYHPEIVLRDFHLLPPRGIHVAPSSLPACIRQPLATLQQQMASLSTTARAVSRSSGSLPTVSRGAFLRTPLSGVNPPSGFFLGEDRSLSAASTAPPDEQSEGIDACGPMVRTASAPSVATSVANQLSVPGGFGAGLCSLKKESSSCGGGGGSARRPPNSGSHQVAAFSELPTAETSHSLPSAYAASLSPFPQAHAQPVSLRSNHVPFASPASQLGLSSSGGGSGGALVSAETLGASGTPAASSSPQVCSTAYSASYSAGFSASAASFASLSGVLTTSASSSAPFARKGELCRETTGQPVTTSDPLSARHTTSTSEAGAGEAVTAAPLSSRGRSELGVSPRVPVTQTAHPYIHKFLAHQRETSRRSSAIVCRATQHAAMPSASLRDRGSSGMFAETKVSLSDSRLPSVCGTVSGHSTSLPSTAAELLAAAQACGASGDGLASCHHASCSGQSCSLPSLGTVGVVSSSLLGLLPSGHPGDKDIEAGLAPDLAFFRGTSFGGRSTSCCVEGVSERSSGFLPNASLTPESSASMALVAALNSFPQTEGEARPGGPLTGHSAPARASHAASGTRCMRSGAETLGTGNGFFSAFGERAATAGPEGAGGSSAQESRTTTRSSVCTDDGAFFLGTPGESCQAQQLPGVTSASLLQQYQKELQQRQFAAHQAQTAQQQKRLQAGGIETVVVEPVQGAAASESNLVGVSRDISFNVGERTVENAMEIEESGRSEASVPQRVSYSLSEQQFLLLRQQQLQHGQQQL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should contain one or more Prot_kinase_dom, Prot_kinase_dom, Prot_kinase_dom that are essential for its biological function; 2. The protein should belong to MAP_kinase that shares evolutionary origin and functional similarity; 3. The protein should be classified within Kinase-like_dom_sf sharing conserved structural features; 4. The protein should contain MAP_kinase_CS that is preserved across related proteins; 5. The protein must have Ser/Thr_kinase_AS that is conserved among related catalytic enzymes. The designed protein sequence is ", "reference": "MSQSTSAGGSQAVAQNPGAKLGFSMRSASIASDSVPCESGLCEAPPGVLSGAGTVFCESTYKVKIDNETVWQVPTRLKFVKKVGSGAYGCVASFEDTSASASEEGTEDDPSRREQSGETRTSQTGSAEGDSGTNKKVAVKKIGDLFRDLIDAKRIYREIKILKELKHENIINLVEILDPLTPDFEDIYLVSDLMDTDLHRVIYSRQPLTPEHHQYFLYQLLLGLSFLHQADIIHRDLKPSNILVNLNCDIKICDFGLARGLNMNPAPPPNLLPPATHRAGPAAAQDVVCTYTPPDNLSGAGKWGDQKLAAAAGAGSIAATRLVRLAHQQGSSLIGAQHQVPAKTDDASDDMELTDYVVTRWYRPPEILISPFCYSKPVDLWSVGCIFAELLGRRALFAGKDHFDQLRRIVRVLGRPSTAEINKVANEGRGRHFNNPSKGTSNTKRKRSEAARRFIESLPNSDPYKLEDLFPDASKAALDLLSNLLTFDPAKRITVQEALRHEYFEGLHSVEDEPTVTTPVNWSFDNFVPTKRLLQNKVYQEIISYHPEIVLRDFHLLPPRGIHVAPSSLPACIRQPLATLQQQMASLSTTARAVSRSSGSLPTVSRGAFLRTPLSGVNPPSGFFLGEDRSLSAASTAPPDEQSEGIDACGPMVRTASAPSVATSVANQLSVPGGFGAGLCSLKKESSSCGGGGGSARRPPNSGSHQVAAFSELPTAETSHSLPSAYAASLSPFPQAHAQPVSLRSNHVPFASPASQLGLSSSGGGSGGALVSAETLGASGTPAASSSPQVCSTAYSASYSAGFSASAASFASLSGVLTTSASSSAPFARKGELCRETTGQPVTTSDPLSARHTTSTSEAGAGEAVTAAPLSSRGRSELGVSPRVPVTQTAHPYIHKFLAHQRETSRRSSAIVCRATQHAAMPSASLRDRGSSGMFAETKVSLSDSRLPSVCGTVSGHSTSLPSTAAELLAAAQACGASGDGLASCHHASCSGQSCSLPSLGTVGVVSSSLLGLLPSGHPGDKDIEAGLAPDLAFFRGTSFGGRSTSCCVEGVSERSSGFLPNASLTPESSASMALVAALNSFPQTEGEARPGGPLTGHSAPARASHAASGTRCMRSGAETLGTGNGFFSAFGERAATAGPEGAGGSSAQESRTTTRSSVCTDDGAFFLGTPGESCQAQQLPGVTSASLLQQYQKELQQRQFAAHQAQTAQQQKRLQAGGIETVVVEPVQGAAASESNLVGVSRDISFNVGERTVENAMEIEESGRSEASVPQRVSYSLSEQQFLLLRQQQLQHGQQQL" }, { "InterPro": [ { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 40, "End": 118 }, { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 40, "End": 115 } ], "response#1": "MFARVSTLFAMFFLGLALMVSATPAALKPVARDTIPASQCNTGDLQCCNTVENADSPSAAALLGLLGVVVQGLDVLVGLTCTPITVIGVGSGANCVQQPVCCENNNFNGLINIGCTPVNLGL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Hydrophobin, Hydrophobin that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MFARVSTLFAMFFLGLALMVSATPAALKPVARDTIPASQCNTGDLQCCNTVENADSPSAAALLGLLGVVVQGLDVLVGLTCTPITVIGVGSGANCVQQPVCCENNNFNGLINIGCTPVNLGL" }, { "InterPro": [ { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 57, "End": 135 }, { "InterPro-ID": "IPR001338", "InterPro-Name": "Hydrophobin", "InterPro-Type": "FAMILY", "Beg": 57, "End": 132 } ], "response#1": "MFFRISTVFVVALAAFAAASPAPWGAPPPTTTTHPPVTTTVTVTAPATTTTIPASQCNTGDAQCCNSVQSATAPAVTSLLGLLGIVLEDINVLVGLSCDPISVIGVGGGANCVQQPVCCENNNFNGLINIGCTPINIFL", "instruction": "Generate a protein sequence for a novel protein that integrates the following function keywords: 1. The protein should belong to Hydrophobin, Hydrophobin that shares evolutionary origin and functional similarity. The designed protein sequence is ", "reference": "MFFRISTVFVVALAAFAAASPAPWGAPPPTTTTHPPVTTTVTVTAPATTTTIPASQCNTGDAQCCNSVQSATAPAVTSLLGLLGIVLEDINVLVGLSCDPISVIGVGGGANCVQQPVCCENNNFNGLINIGCTPINIFL" } ]