interpro_id string | interpro_numeric_id int64 | name string | short_name string | entry_type string | protein_count int64 | is_llm bool | is_llm_reviewed bool | abstract string | go_ids list | go_terms list | go_categories list | go_count int64 | member_databases list | member_accessions list | member_names list | member_protein_counts list | member_count int64 | external_databases list | external_accessions list | external_xrefs list | external_xref_count int64 | pdb_ids list | structure_count int64 | publication_ids list | pubmed_ids list | publication_titles list | publication_years list | publication_count int64 | parent_ids list | child_ids list | parent_count int64 | child_count int64 | tree_depth float64 | taxonomy_names list | taxonomy_protein_counts list | taxonomy_count int64 | key_species_names list | key_species_protein_counts list | key_species_count int64 | in_entry_list bool | entry_list_type string | entry_list_name string | names_dat_name string | short_names_dat_name string | split_bucket int64 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
IPR004669 | 4,669 | C4-dicarboxylate anaerobic carrier | C4_dicarb_anaerob_car | Family | 3,845 | false | false | Escherichia coli contains four different secondary carriers (DcuA, DcuB, DcuC, and DctA) for C4-dicarboxylates [ , , , ] DcuA is used for aerobic growth on C4-dicarboxylates [ , ], whereas the Dcu carriers (encoded by the dcuA, dcuB, and dcuC genes) are used under anaerobic conditions and form a distinct family of carr... | [
"GO:0015556",
"GO:0015740",
"GO:0016020"
] | [
"C4-dicarboxylate transmembrane transporter activity",
"C4-dicarboxylate transport",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"NCBIFAM",
"PANTHER",
"NCBIFAM"
] | [
"NF037994",
"PTHR42002",
"TIGR00771"
] | [
"DcuC_1",
"",
"DcuC"
] | [
3715,
3836,
3407
] | 3 | [] | [] | [] | 0 | [] | 0 | [
"PUB00000013",
"PUB00011102",
"PUB00033878",
"PUB00033879",
"PUB00033884",
"PUB00033885",
"PUB00033886",
"PUB00033887",
"PUB00033888",
"PUB00033889",
"PUB00033890",
"PUB00033891",
"PUB00105500",
"PUB00105501"
] | [
"9889977",
"9765574",
"7961398",
"9852003",
"10482502",
"1512189",
"8955408",
"5541510",
"8020497",
"9230919",
"9973351",
"10368146",
"24323285",
"28223978"
] | [
"Molecular phylogeny as a basis for the classification of transport proteins from bacteria, archaea and eukarya.",
"Fumarate regulation of gene expression in Escherichia coli by the DcuSR (dcuSR genes) two-component regulatory system.",
"Escherichia coli possesses two homologous anaerobic C4-dicarboxylate membr... | [
1998,
1998,
1994,
1998,
1999,
1992,
1996,
1971,
1994,
1997,
1999,
1999,
2014,
2017
] | 14 | [
"IPR018385"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Opisthokonta",
"metagenomes"
] | [
3812,
2,
31
] | 3 | [
"Escherichia coli (strain K12)"
] | [
2
] | 1 | true | Family | C4-dicarboxylate anaerobic carrier | C4-dicarboxylate anaerobic carrier | C4_dicarb_anaerob_car | 3 |
IPR004670 | 4,670 | Na+/H+ antiporter NhaA | NhaA | Family | 17,104 | false | false | NhaA is a sodium ion/proton antiporter that uses the proton electrochemical gradient to expel sodium ions from the cytoplasm and functions primarily in the adaptation to high salinity at alkaline pH. NhaA is also believed to be responsible for adaptation to alkaline pH when sodium is available. NhaA is one of the three... | [
"GO:0006814",
"GO:0006885",
"GO:0016020"
] | [
"sodium ion transport",
"regulation of pH",
"membrane"
] | [
"biological_process",
"biological_process",
"cellular_component"
] | 3 | [
"HAMAP",
"PFAM",
"PANTHER",
"NCBIFAM"
] | [
"MF_01844",
"PF06965",
"PTHR30341",
"TIGR00773"
] | [
"NhaA",
"Na_H_antiport_1",
"",
"NhaA"
] | [
16073,
17102,
16969,
15396
] | 4 | [] | [] | [] | 0 | [
"1zcd",
"3fi1",
"4atv",
"4au5",
"7a0w",
"7a0x",
"7a0y",
"7s24",
"8ps0"
] | 9 | [
"PUB00054014"
] | [
"19448069"
] | [
"NhaA crystal structure: functional-structural insights."
] | [
2009
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Odinarchaeota yellowstonii (strain LCB_4)",
"metagenomes",
"uncultured Caudovirales phage"
] | [
16611,
160,
1,
331,
1
] | 5 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Na+/H+ antiporter NhaA | Na+/H+ antiporter NhaA | NhaA | 3 |
IPR004671 | 4,671 | Na+/H+ antiporter NhaB | Na+/H+_antiporter_NhaB | Family | 3,155 | false | false | The Escherichia coli NhaB Na+:H+ Antiporter (NhaB) protein has 12 predicted TMS, and catalyses sodium/proton exchange. Unlike NhaA, , this activity is not pH dependent. | [
"GO:0015385",
"GO:0006814",
"GO:0016020"
] | [
"sodium:proton antiporter activity",
"sodium ion transport",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"HAMAP",
"NCBIFAM",
"PFAM",
"NCBIFAM"
] | [
"MF_01599",
"NF007093",
"PF06450",
"TIGR00774"
] | [
"NhaB",
"PRK09547.1",
"NhaB",
"NhaB"
] | [
2993,
2952,
3155,
2055
] | 4 | [] | [] | [] | 0 | [] | 0 | [
"PUB00013426",
"PUB00071777",
"PUB00104462",
"PUB00104463",
"PUB00104464"
] | [
"12562793",
"16390457",
"11544242",
"7929345",
"8093613"
] | [
"Roles of NhaA, NhaB, and NhaD Na+/H+ antiporters in survival of Vibrio cholerae in a saline environment.",
"Cloning, functional expression and primary characterization of Vibrio parahaemolyticus K+/H+ antiporter genes in Escherichia coli.",
"Residue aspartate-147 from the third transmembrane region of Na(+)/H(... | [
2003,
2006,
2001,
1994,
1993
] | 5 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
3127,
4,
24
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Na+/H+ antiporter NhaB | Na+/H+ antiporter NhaB | Na+/H+_antiporter_NhaB | 9 |
IPR004672 | 4,672 | Na(+)/H(+) antiporter NhaD | Na(+)/H(+)_antiporter_NhaD | Family | 60 | false | false | These proteins are members of the NhaD Na(+)/H(+) antiporter (NhaD) Family (TC 2.A.62) and include the NhaD protein of Vibrio parahaemolyticus which has been characterised [ ]. It has 12 predicted transmembrane regions and has been shown to catalyse Na+/H+ antiport, though Li+ can also be a substrate. | [
"GO:0015297",
"GO:0006814"
] | [
"antiporter activity",
"sodium ion transport"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"NCBIFAM"
] | [
"TIGR00775"
] | [
"NhaD"
] | [
60
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00061682"
] | [
"9518619"
] | [
"A new Na+/H+ antiporter, NhaD, of Vibrio parahaemolyticus."
] | [
1998
] | 1 | [
"IPR045016"
] | [] | 1 | 0 | 1 | [
"Pseudomonadati"
] | [
60
] | 1 | [] | [] | 0 | true | Family | Na(+)/H(+) antiporter NhaD | Na(+)/H(+) antiporter NhaD | Na(+)/H(+)_antiporter_NhaD | 8 |
IPR004673 | 4,673 | L-rhamnose-proton symport, RhaT | L-rhamnose-proton_sym_RhaT | Family | 2,809 | false | false | These proteins are members of the L-Rhamnose Symporter (RhaT) family. This family includes two characterised members, both of which function as L-rhamnose:H+ symporters and have 10 GES predicted transmembrane domains. | [
"GO:0015153",
"GO:0008645",
"GO:0016020"
] | [
"rhamnose transmembrane transporter activity",
"hexose transmembrane transport",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"HAMAP",
"PFAM"
] | [
"MF_01532",
"PF06379"
] | [
"RhaT",
"RhaT"
] | [
1015,
2809
] | 2 | [
"GP"
] | [
"GenProp0457"
] | [
"GP:GenProp0457"
] | 1 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
2754,
15,
40
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | L-rhamnose-proton symport, RhaT | L-rhamnose-proton symport, RhaT | L-rhamnose-proton_sym_RhaT | 6 |
IPR004674 | 4,674 | Alkylhydroperoxidase AhpD | AhpD | Family | 3,431 | false | false | Alkyl hydroperoxide reductase AhpD catalyse the reduction of peroxides to their corresponding alcohols via oxidation of cysteine residues. In these alkylhydroperoxidases, the cysteines are located in a conserved -CXXC- motif located towards the C terminus. In Mycobacterium tuberculosis, two non-homologous alkylhydroper... | [
"GO:0051920",
"GO:0006979"
] | [
"peroxiredoxin activity",
"response to oxidative stress"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"HAMAP",
"NCBIFAM"
] | [
"MF_01676",
"TIGR00777"
] | [
"AhpD",
"ahpD"
] | [
3431,
2383
] | 2 | [
"EC",
"GP",
"REACTOME"
] | [
"1.11.1.28",
"GenProp0213",
"R-HSA-1222541"
] | [
"EC:1.11.1.28",
"GP:GenProp0213",
"REACTOME:R-HSA-1222541"
] | 3 | [
"1gu9",
"1knc",
"1lw1",
"1me5"
] | 4 | [
"PUB00026775"
] | [
"11799204"
] | [
"Metabolic enzymes of mycobacteria linked to antioxidant defense by a thioredoxin-like protein."
] | [
2002
] | 1 | [] | [] | 0 | 0 | null | [
"Arthropoda",
"Bacteria",
"metagenomes",
"uncultured Caudovirales phage"
] | [
2,
3422,
6,
1
] | 4 | [] | [] | 0 | true | Family | Alkylhydroperoxidase AhpD | Alkylhydroperoxidase AhpD | AhpD | 4 |
IPR004675 | 4,675 | Alkylhydroperoxidase AhpD core | AhpD_core | Domain | 45,898 | false | false | This entry represents the core region of homology among a group of related proteins, including Alkyl hydroperoxide reductase AhpD and Alkyl hydroperoxide reductase Rv2159c Mycobacterium tuberculosis [ ]. Most members in this entry contain the motif Exxxxxx[SA]xxxxC[VIL]xCxxxH. AhpD from Streptococcus pneumoniae contrib... | [
"GO:0032843"
] | [
"hydroperoxide reductase activity"
] | [
"molecular_function"
] | 1 | [
"NCBIFAM"
] | [
"TIGR00778"
] | [
"ahpD_dom"
] | [
45898
] | 1 | [
"EC",
"REACTOME"
] | [
"1.11.1.28",
"R-HSA-1222541"
] | [
"EC:1.11.1.28",
"REACTOME:R-HSA-1222541"
] | 2 | [
"1gu9",
"1knc",
"1lw1",
"1me5",
"1p8c",
"1vke",
"2gmy",
"2ijc",
"2o4d",
"2ouw",
"2oyo",
"2pfx",
"2prr",
"3bey",
"3c1l",
"3lvy",
"5dik",
"5dip",
"6e8l",
"6k40",
"7xw1",
"7y4r"
] | 22 | [
"PUB00022129",
"PUB00163381",
"PUB00163382"
] | [
"12761216",
"26402328",
"31974167"
] | [
"The mechanism of Mycobacterium tuberculosis alkylhydroperoxidase AhpD as defined by mutagenesis, crystallography, and kinetics.",
"Structure of lpg0406, a carboxymuconolactone decarboxylase family protein possibly involved in antioxidative response from Legionella pneumophila.",
"Structure-function analyses of... | [
2003,
2015,
2020
] | 3 | [
"IPR003779"
] | [] | 1 | 0 | 1 | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
812,
44286,
497,
303
] | 4 | [
"Danio rerio"
] | [
1
] | 1 | true | Domain | Alkylhydroperoxidase AhpD core | Alkylhydroperoxidase AhpD core | AhpD_core | 3 |
IPR004676 | 4,676 | Cadmium resistance transporter | Cd-R_transporter | Family | 4,155 | false | false | These proteins are members of the Cadmium Resistance (CadD) family. The CadD family includes two close orthologues in two Staphylococcus species that have been reported to function in cadmium resistance [ ]. | [] | [] | [] | 0 | [
"PFAM",
"NCBIFAM"
] | [
"PF03596",
"TIGR00779"
] | [
"Cad",
"cad"
] | [
4155,
1022
] | 2 | [] | [] | [] | 0 | [] | 0 | [
"PUB00070760"
] | [
"10383976"
] | [
"Cloning and expression of cadD, a new cadmium resistance gene of Staphylococcus aureus."
] | [
1999
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanobacteriota",
"metagenomes"
] | [
3792,
313,
31,
19
] | 4 | [] | [] | 0 | true | Family | Cadmium resistance transporter | Cadmium resistance transporter | Cd-R_transporter | 7 |
IPR004677 | 4,677 | Cytochrome c oxidase cbb3-type, subunit I | Cyt_c_oxidase_cbb3_su1 | Family | 9,585 | false | false | This family represents the largest subunit, I, of the ccb3-type cytochrome c oxidase , with two protohaem's and copper. It shows strong homology to subunits of other types of cytochrome oxidases. Species with this type, all from the proteobacteria so far, include Neisseria meningitidis, Helicobacter pylori, Campylobact... | [
"GO:0004129"
] | [
"cytochrome-c oxidase activity"
] | [
"molecular_function"
] | 1 | [
"NCBIFAM",
"CDD"
] | [
"TIGR00780",
"cd01661"
] | [
"ccoN",
"cbb3_Oxidase_I"
] | [
9566,
5415
] | 2 | [
"EC",
"GP",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"
] | [
"7.1.1.9",
"GenProp0483",
"PWY-3781",
"PWY-4521",
"PWY-6692",
"PWY-7279",
"PWY-7429",
"PWY-8271"
] | [
"EC:7.1.1.9",
"GP:GenProp0483",
"METACYC:PWY-3781",
"METACYC:PWY-4521",
"METACYC:PWY-6692",
"METACYC:PWY-7279",
"METACYC:PWY-7429",
"METACYC:PWY-8271"
] | 8 | [
"3mk7",
"5djq",
"6xkw",
"6xkx",
"6xkz",
"8smr",
"8snh"
] | 7 | [] | [] | [] | [] | 0 | [
"IPR000883"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
9472,
6,
107
] | 3 | [] | [] | 0 | true | Family | Cytochrome c oxidase cbb3-type, subunit I | Cytochrome c oxidase cbb3-type, subunit I | Cyt_c_oxidase_cbb3_su1 | 9 |
IPR004678 | 4,678 | Cytochrome c oxidase cbb3-type, subunit III | Cyt_c_oxidase_cbb3_su3 | Family | 7,071 | false | false | This family describes a di-haem subunit of approximately 26kDa of the cbb3 type copper and haem-containing cytochrome oxidase . | [] | [] | [] | 0 | [
"PIRSF",
"NCBIFAM"
] | [
"PIRSF000006",
"TIGR00782"
] | [
"Cbb3-Cox_fixP",
"ccoP"
] | [
6850,
6804
] | 2 | [
"GP"
] | [
"GenProp0483"
] | [
"GP:GenProp0483"
] | 1 | [
"3mk7",
"5djq",
"6xkw",
"6xkx",
"6xkz",
"8smr",
"8snh"
] | 7 | [] | [] | [] | [] | 0 | [
"IPR008168"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
6973,
7,
91
] | 3 | [] | [] | 0 | true | Family | Cytochrome c oxidase cbb3-type, subunit III | Cytochrome c oxidase cbb3-type, subunit III | Cyt_c_oxidase_cbb3_su3 | 5 |
IPR004679 | 4,679 | 2-hydroxycarboxylate transporter | 2-OHcarboxylate_transport | Family | 3,735 | false | false | The 2-hydroxycarboxylate transporter family is a family of secondary transporters found exclusively in the bacterial kingdom. They function in the metabolism of the di- and tricarboxylates malate and citrate, mostly in fermentative pathways involving decarboxylation of malate or oxaloacetate [ ]. The majority of protei... | [
"GO:0022857",
"GO:0055085",
"GO:0016020"
] | [
"transmembrane transporter activity",
"transmembrane transport",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PFAM",
"PIRSF",
"PANTHER"
] | [
"PF03390",
"PIRSF005348",
"PTHR40033"
] | [
"2HCT",
"YxkH",
""
] | [
3726,
3322,
3720
] | 3 | [] | [] | [] | 0 | [
"5a1s",
"5x9r",
"5xar",
"5xas",
"5xat",
"9lsh",
"9lsi",
"9lsj",
"9lsk"
] | 9 | [
"PUB00034458",
"PUB00034459",
"PUB00034460",
"PUB00044708"
] | [
"8810332",
"11566984",
"12949159",
"16339740"
] | [
"Membrane topology of the sodium ion-dependent citrate carrier of Klebsiella pneumoniae. Evidence for a new structural class of secondary transporters.",
"Bacillus subtilis YxkJ is a secondary transporter of the 2-hydroxycarboxylate transporter family that transports L-malate and citrate.",
"The Bacillus subtil... | [
1996,
2001,
2003,
2005
] | 4 | [] | [
"IPR018025"
] | 0 | 1 | 0 | [
"Bacteria",
"Dickeya phage phiDP10.3",
"Eukaryota",
"Halalkalicoccus tibetensis",
"metagenomes"
] | [
3720,
1,
8,
2,
4
] | 5 | [] | [] | 0 | true | Family | 2-hydroxycarboxylate transporter | 2-hydroxycarboxylate transporter | 2-OHcarboxylate_transport | 4 |
IPR004680 | 4,680 | Citrate transporter-like domain | Cit_transptr-like_dom | Domain | 52,257 | false | false | This domain is found in proteins belonging to the CitM transporter, NhaD Na+/H+ antiporter and Na+/sulfate symporter families, such as CitM from Bacillus subtilis [ ], NhaD from Halomonas elongata [ ] and SLT1 from Chlamydomonas reinhardtii [ ]. | [
"GO:0055085",
"GO:0016020"
] | [
"transmembrane transport",
"membrane"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PFAM"
] | [
"PF03600"
] | [
"CitMHS"
] | [
52257
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-5662702",
"R-MMU-5662702"
] | [
"REACTOME:R-HSA-5662702",
"REACTOME:R-MMU-5662702"
] | 2 | [
"4f35",
"5ul7",
"5ul9",
"5uld",
"5ule",
"6okz",
"6ol0",
"6ol1",
"6wtx",
"6wu3",
"6ww5",
"7t9f",
"7t9g",
"8r33",
"8r34",
"8r35"
] | 16 | [
"PUB00078038",
"PUB00078039",
"PUB00078040"
] | [
"16872527",
"11891560",
"20498339"
] | [
"NhaD type sodium/proton-antiporter of Halomonas elongata: a salt stress response mechanism in marine habitats?",
"Functional characterization of CitM, the Mg2+-citrate transporter.",
"Identification and regulation of plasma membrane sulfate transporters in Chlamydomonas."
] | [
2006,
2002,
2010
] | 3 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Oenococcus phage fOg30",
"unclassified sequences"
] | [
1285,
40508,
9754,
1,
709
] | 5 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae... | [
14,
2,
16,
2,
4,
1,
1,
24,
6,
3,
30
] | 11 | true | Domain | Citrate transporter-like domain | Citrate transporter-like domain | Cit_transptr-like_dom | 2 |
IPR004681 | 4,681 | TRAP transporter large membrane protein DctM | TRAP_DctM | Family | 54,323 | false | false | The tripartite ATP-independent periplasmic (TRAP) transport system is firmly established as a new type of extracytoplasmic solute receptor (ESR)-dependent uptake systems, unrelated to ABC transporters. In TRAP transport systems the driving force for solute accumulation is an electrochemical ion gradient and not ATP hyd... | [
"GO:0016020"
] | [
"membrane"
] | [
"cellular_component"
] | 1 | [
"PIRSF",
"PANTHER",
"NCBIFAM"
] | [
"PIRSF006066",
"PTHR33362",
"TIGR00786"
] | [
"HI0050",
"",
"dctM"
] | [
42171,
54282,
44924
] | 3 | [
"GP",
"GP"
] | [
"GenProp0176",
"GenProp0714"
] | [
"GP:GenProp0176",
"GP:GenProp0714"
] | 2 | [
"7qe5",
"7qha",
"8b01",
"8thi",
"8thj",
"8y4w",
"8y4x",
"9pym"
] | 8 | [
"PUB00007692",
"PUB00015015",
"PUB00044822",
"PUB00060348",
"PUB00060349"
] | [
"9287004",
"11524131",
"16262798",
"14668138",
"16385129"
] | [
"TRAP transporters: a new family of periplasmic solute transport systems encoded by the dctPQM genes of Rhodobacter capsulatus and by homologs in diverse gram-negative bacteria.",
"The tripartite ATP-independent periplasmic (TRAP) transporters of bacteria and archaea.",
"Sialic acid transport in Haemophilus inf... | [
1997,
2001,
2005,
2004,
2006
] | 5 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Sym plasmid",
"unclassified sequences"
] | [
114,
52957,
70,
2,
1180
] | 5 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | TRAP transporter large membrane protein DctM | TRAP transporter large membrane protein DctM | TRAP_DctM | 3 |
IPR004682 | 4,682 | TRAP transporter solute receptor, DctP family | TRAP_DctP | Family | 26,752 | false | false | Substrate-binding proteins (SBPs) are extracytoplasmic proteins involved in substrate recognition for several different bacterial transporters. This entry includes a subset of the DctP family of the substrate-binding proteins. They are part of the DctP-TRAP (tripartite ATP-independent periplasmic) transporter. Proteins... | [
"GO:0055085",
"GO:0030288"
] | [
"transmembrane transport",
"outer membrane-bounded periplasmic space"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PIRSF",
"NCBIFAM"
] | [
"PIRSF006470",
"TIGR00787"
] | [
"DctB",
"dctP"
] | [
25655,
25490
] | 2 | [
"GP",
"GP"
] | [
"GenProp0176",
"GenProp0714"
] | [
"GP:GenProp0176",
"GP:GenProp0714"
] | 2 | [
"2cex",
"2cey",
"2hpg",
"2v4c",
"2wx9",
"2wyk",
"2wyp",
"2xa5",
"2xwi",
"2xwk",
"2xwo",
"2xwv",
"2xxk",
"3b50",
"4ln5",
"4mag",
"4mhf",
"4mij",
"4mmp",
"4mnp",
"4mx6",
"4n15",
"4n17",
"4n8g",
"4n8y",
"4n91",
"4nf0",
"4ng7",
"4nn3",
"4nq8",
"4nx1",
"4o7m"... | 87 | [
"PUB00078592",
"PUB00078596"
] | [
"20584082",
"10708364"
] | [
"Tripartite ATP-independent periplasmic (TRAP) transporters in bacteria and archaea.",
"Regulation of the transport system for C4-dicarboxylic acids in Bacillus subtilis."
] | [
2011,
2000
] | 2 | [
"IPR018389"
] | [] | 1 | 0 | 1 | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences",
"uncultured Caudovirales phage"
] | [
3,
26493,
22,
233,
1
] | 5 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | TRAP transporter solute receptor, DctP family | TRAP transporter solute receptor, DctP family | TRAP_DctP | 5 |
IPR004683 | 4,683 | Type III secretion system substrate exporter FlhB-like | T3SS_FlhB-rel | Family | 234 | false | false | This group describes a short protein (80-93 residues) homologous to the C terminus of the flagellar biosynthetic protein FlhB. It is found so far only in species that also have FlhB. In a phylogenetic tree based on alignment of both this family and the homologous region of FlhB and its homologues, the members of this f... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"TIGR00789"
] | [
"flhB_rel"
] | [
234
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [
"IPR006135"
] | [] | 1 | 0 | 1 | [
"Bacteria"
] | [
234
] | 1 | [] | [] | 0 | true | Family | Type III secretion system substrate exporter FlhB-like | Type III secretion system substrate exporter FlhB-like | T3SS_FlhB-rel | 9 |
IPR004684 | 4,684 | 2-keto-3-deoxygluconate permease | 2keto-3dGluconate_permease | Family | 3,881 | false | false | This family includes the characterised 2-Keto-3-Deoxygluconate transporters from Bacillus subtilis and Erwinia chrysanthemi. There are homologues of this protein found in both Gram-positive and Gram-negative bacteria. In E. chrysanthemi, a phytopathogenic bacterium, degraded pectin products from plant cell walls are tr... | [
"GO:0015649",
"GO:0008643",
"GO:0046411",
"GO:0016020"
] | [
"2-keto-3-deoxygluconate:proton symporter activity",
"carbohydrate transport",
"2-keto-3-deoxygluconate transmembrane transport",
"membrane"
] | [
"molecular_function",
"biological_process",
"biological_process",
"cellular_component"
] | 4 | [
"HAMAP",
"PFAM"
] | [
"MF_00070",
"PF03812"
] | [
"KdgT",
"KdgT"
] | [
2008,
3881
] | 2 | [] | [] | [] | 0 | [] | 0 | [
"PUB00043309",
"PUB00043310"
] | [
"2684787",
"3571157"
] | [
"Nucleotide sequence of the Erwinia chrysanthemi gene encoding 2-keto-3-deoxygluconate permease.",
"2-keto-3-deoxygluconate transport system in Erwinia chrysanthemi."
] | [
1989,
1987
] | 2 | [] | [
"IPR018395"
] | 0 | 1 | 0 | [
"Bacteria",
"Eukaryota",
"Halobacteriales",
"metagenomes"
] | [
3858,
3,
6,
14
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | 2-keto-3-deoxygluconate permease | 2-keto-3-deoxygluconate permease | 2keto-3dGluconate_permease | 9 |
IPR004685 | 4,685 | Branched-chain amino acid transport system II carrier protein | Brnchd-chn_aa_trnsp_Livcs | Family | 12,604 | false | false | Characterised members of the branched chain Amino Acid:Cation Symporter (LIVCS) family transport all three of the branched chain aliphatic amino acids (leucine (L), isoleucine (I) and valine (V)) [ ]. They function by a Na+ or H+ symport mechanism and display 12 putative transmembrane helical spanners. | [
"GO:0015658",
"GO:0015803",
"GO:0016020"
] | [
"branched-chain amino acid transmembrane transporter activity",
"branched-chain amino acid transport",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PFAM",
"PANTHER",
"NCBIFAM"
] | [
"PF05525",
"PTHR30588",
"TIGR00796"
] | [
"Branch_AA_trans",
"",
"livcs"
] | [
12604,
12541,
11935
] | 3 | [] | [] | [] | 0 | [] | 0 | [
"PUB00011268"
] | [
"8544834"
] | [
"Cloning and characterization of brnQ, a gene encoding a low-affinity, branched-chain amino acid carrier in Lactobacillus delbruckii subsp. lactis DSM7290."
] | [
1995
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Opisthokonta",
"metagenomes"
] | [
12555,
7,
42
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Branched-chain amino acid transport system II carrier protein | Branched-chain amino acid transport system II carrier protein | Brnchd-chn_aa_trnsp_Livcs | 5 |
IPR004686 | 4,686 | Tricarboxylate/iron carrier | Mtc | Family | 10,083 | false | false | The MTC family consists of a limited number of homologues, all from eukaryotes. One member of the family has been functionally characterised as a tricarboxylate carrier from rat liver mitochondria. The rat liver mitochondrial tricarboxylate carrier has been reported to transport citrate, cis-aconitate, threo-D-isocitra... | [
"GO:0015075",
"GO:0006811",
"GO:0055085",
"GO:0016020"
] | [
"monoatomic ion transmembrane transporter activity",
"monoatomic ion transport",
"transmembrane transport",
"membrane"
] | [
"molecular_function",
"biological_process",
"biological_process",
"cellular_component"
] | 4 | [
"PFAM",
"PANTHER",
"NCBIFAM"
] | [
"PF03820",
"PTHR11153",
"TIGR00798"
] | [
"SFXNs",
"",
"mtc"
] | [
10082,
9901,
6259
] | 3 | [
"REACTOME",
"REACTOME"
] | [
"R-BTA-6799198",
"R-HSA-6799198"
] | [
"REACTOME:R-BTA-6799198",
"REACTOME:R-HSA-6799198"
] | 2 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
10083
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strai... | [
10,
29,
2,
29,
14,
1,
31,
1,
1
] | 9 | true | Family | Tricarboxylate/iron carrier | Tricarboxylate/iron carrier | Mtc | 5 |
IPR004687 | 4,687 | Lysosomal-associated transmembrane protein 4/5 | LAPTM4/5 | Family | 2,994 | false | false | The lysosome associated protein transmembrane (LAPTM) family is comprised of three members: LAPTM5, LAPTM4a and LAPTM4b; they are lysosome-associated transmembrane proteins, found in mammals, insects and nematodes. | [
"GO:0016020"
] | [
"membrane"
] | [
"cellular_component"
] | 1 | [
"PFAM"
] | [
"PF03821"
] | [
"Mtp"
] | [
2994
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [
"IPR018396"
] | 0 | 1 | 0 | [
"Eukaryota"
] | [
2994
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
3,
11,
24,
12
] | 5 | true | Family | Lysosomal-associated transmembrane protein 4/5 | Lysosomal-associated transmembrane protein 4/5 | LAPTM4/5 | 6 |
IPR004688 | 4,688 | Transition metal uptake transporter nickel/cobalt | Ni/Co_transpt | Family | 6,432 | false | false | This family is found in both Gram-negative and Gram-positive bacteria. The functionally characterised members of the family catalyse uptake of either Ni2+ or Co2+ in a proton motive force-dependent process [ ]. Topological analyses with the HoxN Ni2+ transporter of Ralstonia eutropha suggest that it possesses 8 TMSs wi... | [
"GO:0035444",
"GO:0005886"
] | [
"nickel cation transmembrane transport",
"plasma membrane"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PANTHER",
"NCBIFAM"
] | [
"PTHR31611",
"TIGR00802"
] | [
"",
"nico"
] | [
6431,
3784
] | 2 | [
"GP"
] | [
"GenProp0051"
] | [
"GP:GenProp0051"
] | 1 | [] | 0 | [
"PUB00072948",
"PUB00072949"
] | [
"7896709",
"10201093"
] | [
"The Alcaligenes eutrophus protein HoxN mediates nickel transport in Escherichia coli.",
"Selective transport of divalent cations by transition metal permeases: the Alcaligenes eutrophus HoxN and the Rhodococcus rhodochrous NhlF."
] | [
1995,
1999
] | 2 | [
"IPR011541"
] | [] | 1 | 0 | 1 | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
88,
4702,
1551,
91
] | 4 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
1
] | 2 | true | Family | Transition metal uptake transporter nickel/cobalt | Transition metal uptake transporter nickel/cobalt | Ni/Co_transpt | 7 |
IPR004690 | 4,690 | Malonate transporter MadL subunit | Maln_transptMadL | Family | 1,464 | false | false | The MSS family includes the monobasic malonate:Na+ symporter of Malonomonas rubra [ ]. It consists of two integral membrane proteins, MadL and MadM. The transporter is believed to catalyse the electroneutral reversible uptake of H+-malonate with one Na+, and both subunits have been shown to be essential for activity [ ... | [
"GO:0016020"
] | [
"membrane"
] | [
"cellular_component"
] | 1 | [
"PFAM",
"NCBIFAM"
] | [
"PF03817",
"TIGR00807"
] | [
"MadL",
"malonate_madL"
] | [
1464,
1431
] | 2 | [
"GP"
] | [
"GenProp0674"
] | [
"GP:GenProp0674"
] | 1 | [] | 0 | [
"PUB00043060",
"PUB00060976"
] | [
"9128730",
"9573154"
] | [
"Sequence of a gene cluster from Malonomonas rubra encoding components of the malonate decarboxylase Na+ pump and evidence for their function.",
"Identification of an Na+-dependent malonate transporter of Malonomonas rubra and its dependence on two separate genes."
] | [
1997,
1998
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Pleodorina starrii",
"ecological metagenomes"
] | [
1456,
1,
7
] | 3 | [] | [] | 0 | true | Family | Malonate transporter MadL subunit | Malonate transporter MadL subunit | Maln_transptMadL | 3 |
IPR004691 | 4,691 | Malonate/sodium symporter MadM subunit | Mal/Na_symporter_MadM | Family | 1,483 | false | false | The MSS family includes the monobasic malonate:Na+ symporter of Malonomonas rubra. It consists of two integral membrane proteins, MadL and MadM [ ].The transporter is believed to catalyze the electroneutral reversible uptake of H+-malonate with one Na+, and both subunits have been shown to be essential for activity. | [
"GO:0044668"
] | [
"sodium:malonate symporter activity"
] | [
"molecular_function"
] | 1 | [
"NCBIFAM"
] | [
"TIGR00808"
] | [
"malonate_madM"
] | [
1483
] | 1 | [
"GP"
] | [
"GenProp0674"
] | [
"GP:GenProp0674"
] | 1 | [] | 0 | [
"PUB00060976"
] | [
"9573154"
] | [
"Identification of an Na+-dependent malonate transporter of Malonomonas rubra and its dependence on two separate genes."
] | [
1998
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"ecological metagenomes"
] | [
1472,
2,
9
] | 3 | [] | [] | 0 | true | Family | Malonate/sodium symporter MadM subunit | Malonate/sodium symporter MadM subunit | Mal/Na_symporter_MadM | 6 |
IPR004692 | 4,692 | Preprotein translocase SecG subunit | SecG | Family | 24,464 | false | false | Secretion across the inner membrane in some Gram-negative bacteria occurs via the preprotein translocase pathway. Proteins are produced in the cytoplasm as precursors, and require a chaperone subunit to direct them to the translocase component [ ]. From there, the mature proteins are either targeted to the outer membra... | [
"GO:0015450",
"GO:0009306",
"GO:0016020"
] | [
"protein-transporting ATPase activity",
"protein secretion",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PFAM",
"PRINTS",
"PANTHER",
"NCBIFAM"
] | [
"PF03840",
"PR01651",
"PTHR34182",
"TIGR00810"
] | [
"SecG",
"SECGEXPORT",
"",
"secG"
] | [
24375,
19531,
18632,
24310
] | 4 | [
"GP",
"GP",
"GP",
"REACTOME",
"REACTOME"
] | [
"GenProp0209",
"GenProp1132",
"GenProp1176",
"R-HSA-1222387",
"R-HSA-9760173"
] | [
"GP:GenProp0209",
"GP:GenProp1132",
"GP:GenProp1176",
"REACTOME:R-HSA-1222387",
"REACTOME:R-HSA-9760173"
] | 5 | [
"2akh",
"2aki",
"3din",
"3dl8",
"3j45",
"3j46",
"5aww",
"5ch4",
"5mg3",
"5nco"
] | 10 | [
"PUB00007064",
"PUB00007065",
"PUB00007066",
"PUB00007693",
"PUB00007694"
] | [
"2202721",
"11336818",
"10418149",
"7650029",
"11445571"
] | [
"The sec and prl genes of Escherichia coli.",
"SecB, a molecular chaperone with two faces.",
"Effects of pre-protein overexpression on SecB synthesis in Escherichia coli.",
"SecYEG and SecA are the stoichiometric components of preprotein translocase.",
"Mapping the sites of interaction between SecY and SecE... | [
1990,
2001,
1999,
1995,
2001
] | 5 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified Caudoviricetes",
"unclassified sequences",
"uncultured marine group III euryarchaeote KM3-28-E8"
] | [
23720,
242,
2,
499,
1
] | 5 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Preprotein translocase SecG subunit | Preprotein translocase SecG subunit | SecG | 3 |
IPR004693 | 4,693 | Silicon transporter | Silicon_transpt | Family | 596 | false | false | Marine diatoms such as Cylindrotheca fusiformis encode at least six silicon transport protein homologues which exhibit similar size and topology. One characterised member of the family (Sit1) functions in the energy-dependent uptake of either silicic acid [Si(OH)4] or silicate [Si(OH)3O-] by a Na + symport mechanism [ ... | [
"GO:0015708"
] | [
"silicic acid import across plasma membrane"
] | [
"biological_process"
] | 1 | [
"PFAM"
] | [
"PF03842"
] | [
"Silic_transp"
] | [
596
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00062323"
] | [
"9894919"
] | [
"Characterization of a silicon transporter gene family in Cylindrotheca fusiformis: sequences, expression analysis, and identification of homologs in other diatoms."
] | [
1998
] | 1 | [] | [
"IPR018403"
] | 0 | 1 | 0 | [
"Bacteria",
"Eukaryota"
] | [
3,
593
] | 2 | [] | [] | 0 | true | Family | Silicon transporter | Silicon transporter | Silicon_transpt | 4 |
IPR004694 | 4,694 | Hydroxy amino acid transporter | Hydroxy_aa_transpt | Family | 3,291 | false | false | The Hydroxy/Aromatic Amino Acid Permease (HAAAP) family includes well characterised aromatic amino acid:H+ symport permeases and hydroxy amino acid permeases. This group is specific for hydroxy amino acid transporters and includes the serine permease, SdaC [ , ] and threonine/serine permease, TdcC, of Escherichia coli ... | [
"GO:0015171",
"GO:0006865",
"GO:0016020"
] | [
"amino acid transmembrane transporter activity",
"amino acid transport",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"NCBIFAM"
] | [
"TIGR00814"
] | [
"stp"
] | [
3291
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00060294",
"PUB00087359",
"PUB00101732"
] | [
"9498571",
"8026499",
"31680488"
] | [
"Isolation and characterization of an Escherichia coli mutant lacking the major serine transporter, and cloning of a serine transporter gene.",
"Sequencing and characterization of the sdaC gene and identification of the sdaCB operon in Escherichia coli K12.",
"The serine transporter SdaC prevents cell lysis upo... | [
1997,
1994,
2020
] | 3 | [
"IPR018227"
] | [
"IPR023726"
] | 1 | 1 | 0 | [
"Bacteria",
"Beauveria bassiana D1-5"
] | [
3290,
1
] | 2 | [
"Escherichia coli (strain K12)"
] | [
2
] | 1 | true | Family | Hydroxy amino acid transporter | Hydroxy amino acid transporter | Hydroxy_aa_transpt | 4 |
IPR004695 | 4,695 | Transporter protein SLAC1/Mae1/ Ssu1/TehA | SLAC1/Mae1/Ssu1/TehA | Family | 20,558 | false | false | Each of these transporters has ten α helical transmembrane segments [ ]. The structure of a bacterial homologue of SLAC1 shows it to have a trimeric arrangement. The pore is composed of five helices with a conserved Phe residue involved in gating. One homologue, Mae1 from the yeast Schizosaccharomyces pombe, functions ... | [
"GO:0055085",
"GO:0016020"
] | [
"transmembrane transport",
"membrane"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PFAM"
] | [
"PF03595"
] | [
"SLAC1"
] | [
20558
] | 1 | [] | [] | [] | 0 | [
"3m71",
"3m72",
"3m73",
"3m74",
"3m75",
"3m76",
"3m77",
"3m78",
"3m7b",
"3m7c",
"3m7e",
"3m7l",
"4ycr",
"7en0",
"7wnq",
"8en9",
"8gw6",
"8gw7",
"8j0j",
"8j1e",
"8vi2",
"8vi3",
"8vi4",
"8vi5"
] | 24 | [
"PUB00066753",
"PUB00066754"
] | [
"20981093",
"18305484"
] | [
"Homologue structure of the SLAC1 anion channel for closing stomata in leaves.",
"SLAC1 is required for plant guard cell S-type anion channel function in stomatal signalling."
] | [
2010,
2008
] | 2 | [] | [
"IPR011552",
"IPR030183",
"IPR030185"
] | 0 | 3 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
172,
10399,
9922,
65
] | 4 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",
"Zea mays"
] | [
22,
1,
4,
34,
1,
6,
35
] | 7 | true | Family | Transporter protein SLAC1/Mae1/ Ssu1/TehA | Transporter protein SLAC1/Mae1/ Ssu1/TehA | SLAC1/Mae1/Ssu1/TehA | 5 |
IPR004697 | 4,697 | p-Aminobenzoyl-glutamate transport protein AbgT | AbgT | Family | 6,843 | false | false | AbgT catalyzes the concentration-dependent uptake of p-aminobenzoyl-glutamate (PABA-GLU) into cells. This allows accumulation of PABA-GLU to a concentration enabling AbgAB to catalyze cleavage into p-aminobenzoate and glutamate [ ]. | [
"GO:0015558",
"GO:1902604"
] | [
"secondary active p-aminobenzoyl-glutamate transmembrane transporter activity",
"p-aminobenzoyl-glutamate transmembrane transport"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM",
"PANTHER"
] | [
"PF03806",
"PTHR30282"
] | [
"ABG_transport",
""
] | [
6842,
6734
] | 2 | [] | [] | [] | 0 | [
"4r0c",
"4r1i"
] | 2 | [
"PUB00060288"
] | [
"17307853"
] | [
"Escherichia coli abg genes enable uptake and cleavage of the folate catabolite p-aminobenzoyl-glutamate."
] | [
2007
] | 1 | [] | [
"IPR011540"
] | 0 | 1 | 0 | [
"Bacteria",
"Eukaryota",
"Thermococcus",
"metagenomes"
] | [
6770,
5,
3,
65
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | p-Aminobenzoyl-glutamate transport protein AbgT | p-Aminobenzoyl-glutamate transport protein AbgT | AbgT | 9 |
IPR004698 | 4,698 | Zinc/iron permease, fungal/plant | Zn/Fe_permease_fun/pln | Family | 7,855 | false | false | Members of the zinc (Zn2+)-Iron (Fe2+) permease (ZIP) family consist of proteins with eight putative transmembrane spanners. They are derived from animals, plants and yeast. They comprise a diverse family, with several paralogues in any one organism (e.g., at least five in Caenorhabditis elegans, at least five in Arabi... | [
"GO:0005385",
"GO:0071577",
"GO:0016020"
] | [
"zinc ion transmembrane transporter activity",
"zinc ion transmembrane transport",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"NCBIFAM"
] | [
"TIGR00820"
] | [
"zip"
] | [
7855
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [
"IPR003689"
] | [] | 1 | 0 | 1 | [
"Eukaryota"
] | [
7855
] | 1 | [
"Arabidopsis thaliana",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",
"Zea mays"
] | [
53,
1,
19,
2,
1,
33
] | 6 | true | Family | Zinc/iron permease, fungal/plant | Zinc/iron permease, fungal/plant | Zn/Fe_permease_fun/pln | 1 |
IPR004699 | 4,699 | Phosphotransferase system, enzyme II sorbitol-specific factor | PTS_IID_sorb | Family | 2,274 | false | false | Bacterial PTS transporters transport and concomitantly phosphorylate their sugar substrates, and typically consist of multiple subunits or protein domains.The Man family is unique in several respects among PTS permease families. It is the only PTS family in which members possess a IID protein. It is the only PTS family... | [
"GO:0009401",
"GO:0016020"
] | [
"phosphoenolpyruvate-dependent sugar phosphotransferase system",
"membrane"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"NCBIFAM",
"PFAM",
"PIRSF",
"PROFILE",
"PANTHER",
"NCBIFAM"
] | [
"NF049923",
"PF03608",
"PIRSF038321",
"PS51107",
"PTHR40399",
"TIGR00821"
] | [
"PTSGlctlSorbSrlA",
"EII-GUT",
"PTS_glc_srb_IIC",
"PTS_EIIC_TYPE_5",
"",
"EII-GUT"
] | [
2204,
2274,
2005,
2209,
2256,
1907
] | 6 | [
"GP",
"PROSITEDOC"
] | [
"GenProp0119",
"PDOC51103"
] | [
"GP:GenProp0119",
"PROSITEDOC:PDOC51103"
] | 2 | [] | 0 | [
"PUB00002449",
"PUB00012919",
"PUB00159492"
] | [
"3553176",
"3062173",
"1100608"
] | [
"Glucitol-specific enzymes of the phosphotransferase system in Escherichia coli. Nucleotide sequence of the gut operon.",
"Positive and negative regulators for glucitol (gut) operon expression in Escherichia coli.",
"Nature and properties of hexitol transport systems in Escherichia coli."
] | [
1987,
1988,
1975
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Trichuris trichiura",
"metagenomes"
] | [
2260,
1,
13
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Phosphotransferase system, enzyme II sorbitol-specific factor | Phosphotransferase system, enzyme II sorbitol-specific factor | PTS_IID_sorb | 2 |
IPR004700 | 4,700 | Phosphotransferase system, mannose/fructose/sorbose family, IIC subunit | PTS_IIC_man | Family | 11,461 | false | false | Bacterial PTS transporters transport and concomitantly phosphorylate their sugar substrates, and typically consist of multiple subunits or protein domains. The Mannose (Man) family is unique in several respects among PTS permease families [ ]. It is the only PTS family in which members possess a IID protein. It is the ... | [
"GO:0009401",
"GO:0016020"
] | [
"phosphoenolpyruvate-dependent sugar phosphotransferase system",
"membrane"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PFAM",
"PROFILE",
"NCBIFAM"
] | [
"PF03609",
"PS51106",
"TIGR00822"
] | [
"EII-Sor",
"PTS_EIIC_TYPE_4",
"EII-Sor"
] | [
11461,
11009,
1989
] | 3 | [
"GP",
"PROSITEDOC"
] | [
"GenProp0119",
"PDOC51103"
] | [
"GP:GenProp0119",
"PROSITEDOC:PDOC51103"
] | 2 | [
"6k1h",
"7dyr",
"7vlx",
"7vly",
"7xno",
"7xtg",
"8hfs",
"9wjr",
"9wju",
"9wjw"
] | 10 | [
"PUB00017925"
] | [
"15667312"
] | [
"Evolution of the bacterial phosphotransferase system: from carriers and enzymes to group translocators."
] | [
2005
] | 1 | [] | [
"IPR047835"
] | 0 | 1 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
11,
11401,
8,
41
] | 4 | [
"Escherichia coli (strain K12)"
] | [
3
] | 1 | true | Family | Phosphotransferase system, mannose/fructose/sorbose family, IIC subunit | Phosphotransferase system, mannose/fructose/sorbose family, IIC subunit | PTS_IIC_man | 2 |
IPR004702 | 4,702 | Phosphotransferease, sorbitol phosphotransferase enzyme II | PTS_sorb_EIIBC | Family | 2,705 | false | false | Bacterial PTS transporters transport and concomitantly phosphorylate their sugar substrates, and typically consist of multiple subunits or protein domains. The Man family is unique in several respects among PTS permease families. It is the only PTS family in which members possess a IID protein. It is the only PTS famil... | [
"GO:0008982",
"GO:0009401",
"GO:0016020"
] | [
"protein-N(PI)-phosphohistidine-sugar phosphotransferase activity",
"phosphoenolpyruvate-dependent sugar phosphotransferase system",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"NCBIFAM",
"PANTHER",
"NCBIFAM"
] | [
"NF049924",
"PTHR39427",
"TIGR00825"
] | [
"PTSGlctlSorbSrlE",
"",
"EIIBC-GUT"
] | [
2358,
2705,
1597
] | 3 | [
"EC",
"GP"
] | [
"2.7.1.198",
"GenProp0119"
] | [
"EC:2.7.1.198",
"GP:GenProp0119"
] | 2 | [] | 0 | [
"PUB00002449",
"PUB00012919",
"PUB00159492"
] | [
"3553176",
"3062173",
"1100608"
] | [
"Glucitol-specific enzymes of the phosphotransferase system in Escherichia coli. Nucleotide sequence of the gut operon.",
"Positive and negative regulators for glucitol (gut) operon expression in Escherichia coli.",
"Nature and properties of hexitol transport systems in Escherichia coli."
] | [
1987,
1988,
1975
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Ecdysozoa",
"metagenomes"
] | [
2689,
2,
14
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Phosphotransferease, sorbitol phosphotransferase enzyme II | Phosphotransferease, sorbitol phosphotransferase enzyme II | PTS_sorb_EIIBC | 9 |
IPR004703 | 4,703 | Phosphotransferase system, sugar-specific permease component | PTS_sugar-sp_permease | Family | 13,600 | false | false | The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active-transport system, catalyses the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. This family includes the IIC component of the ascorbate-specific PTS system, Ul... | [
"GO:0009401",
"GO:0016020"
] | [
"phosphoenolpyruvate-dependent sugar phosphotransferase system",
"membrane"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PFAM"
] | [
"PF03611"
] | [
"EIIC-GAT"
] | [
13600
] | 1 | [
"GP"
] | [
"GenProp0119"
] | [
"GP:GenProp0119"
] | 1 | [
"4rp8",
"4rp9",
"5zov",
"9u82",
"9u84",
"9u8e",
"9u8h"
] | 7 | [
"PUB00054949"
] | [
"14996803"
] | [
"Regulation of expression of the divergent ulaG and ulaABCDEF operons involved in LaAscorbate dissimilation in Escherichia coli."
] | [
2004
] | 1 | [] | [
"IPR013853"
] | 0 | 1 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
24,
13536,
11,
29
] | 4 | [
"Escherichia coli (strain K12)"
] | [
3
] | 1 | true | Family | Phosphotransferase system, sugar-specific permease component | Phosphotransferase system, sugar-specific permease component | PTS_sugar-sp_permease | 8 |
IPR004704 | 4,704 | Phosphotransferase system, mannose/fructose/sorbose family IID component | PTS_IID_man | Family | 11,807 | false | false | The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS) [ , ] is a major carbohydrate transport system in bacteria. The PTS catalyses the phosphorylation of incoming sugar substrates and coupled with translocation across the cell membrane, makes the PTS a link between the uptake and metabolism of sugars... | [
"GO:0009401",
"GO:0016020"
] | [
"phosphoenolpyruvate-dependent sugar phosphotransferase system",
"membrane"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PFAM",
"PROFILE",
"NCBIFAM"
] | [
"PF03613",
"PS51108",
"TIGR00828"
] | [
"EIID-AGA",
"PTS_EIID",
"EIID-AGA"
] | [
11807,
11732,
3477
] | 3 | [
"GP",
"PROSITEDOC"
] | [
"GenProp0119",
"PDOC51108"
] | [
"GP:GenProp0119",
"PROSITEDOC:PDOC51108"
] | 2 | [
"6k1h",
"7dyr",
"7vlx",
"7vly",
"7xno",
"7xtg",
"8hfs",
"9wjr",
"9wju",
"9wjw"
] | 10 | [
"PUB00000073",
"PUB00002162",
"PUB00003612",
"PUB00017027",
"PUB00017028"
] | [
"2197982",
"1537788",
"8246840",
"7815935",
"11361063"
] | [
"The bacterial phosphoenolpyruvate: glycose phosphotransferase system.",
"Proposed uniform nomenclature for the proteins and protein domains of the bacterial phosphoenolpyruvate: sugar phosphotransferase system.",
"Phosphoenolpyruvate:carbohydrate phosphotransferase systems of bacteria.",
"The bacterial phosp... | [
1990,
1992,
1993,
1994,
2001
] | 5 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
11,
11735,
6,
55
] | 4 | [
"Escherichia coli (strain K12)"
] | [
2
] | 1 | true | Family | Phosphotransferase system, mannose/fructose/sorbose family IID component | Phosphotransferase system, mannose/fructose/sorbose family IID component | PTS_IID_man | 2 |
IPR004705 | 4,705 | Cation/H+ exchanger, CPA1 family, bacteria | Cation/H_exchanger_CPA1_bac | Family | 11,787 | false | false | Sodium proton exchangers (NHEs) constitute a large family of integral membrane protein transporters that are responsible for the counter-transport of protons and sodium ions across lipid bilayers [ , ]. These proteins are found in organisms across all domains of life. In archaea, bacteria, yeast and plants, these excha... | [
"GO:0015385",
"GO:0006812",
"GO:1902600",
"GO:0016020"
] | [
"sodium:proton antiporter activity",
"monoatomic cation transport",
"proton transmembrane transport",
"membrane"
] | [
"molecular_function",
"biological_process",
"biological_process",
"cellular_component"
] | 4 | [
"NCBIFAM"
] | [
"TIGR00831"
] | [
"a_cpa1"
] | [
11787
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00001715",
"PUB00002996",
"PUB00003039",
"PUB00044825",
"PUB00044828",
"PUB00044829",
"PUB00044830",
"PUB00044831",
"PUB00044832",
"PUB00044833",
"PUB00044834"
] | [
"9537504",
"9278382",
"9507001",
"11700351",
"12027219",
"12502567",
"16734752",
"17071327",
"16513813",
"11187762",
"17218973"
] | [
"Comparative molecular analysis of Na+/H+ exchangers: a unified model for Na+/H+ antiport?",
"Na+/H+ exchangers of mammalian cells.",
"Identification of a mitochondrial Na+/H+ exchanger.",
"Deletion of one of two Escherichia coli genes encoding putative Na+/H+ exchangers (ycgO) perturbs cytoplasmic alkali cat... | [
1998,
1997,
1998,
2001,
2002,
2002,
2006,
2006,
2006,
2000,
2006
] | 11 | [
"IPR018422"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Eukaryota",
"Methanobacteriota",
"unclassified sequences"
] | [
11744,
3,
27,
13
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Cation/H+ exchanger, CPA1 family, bacteria | Cation/H+ exchanger, CPA1 family, bacteria | Cation/H_exchanger_CPA1_bac | 4 |
IPR004706 | 4,706 | Arsenical-resistance protein Acr3 | Arsenical-R_Acr3 | Family | 19,026 | false | false | Members of the ACR3 family of arsenite (As(III)) permeases confer resistance to arsenic by extrusion from cells [ ]. They exist in prokaryotes and eukaryotes (lower plants and fungi) [ , ]. The ACR3 permeases have ten-transmembrane span topology [ ]. Corynebacterium glutamicum has three Acr3 proteins, CgAcr3-1, CgAcr3-... | [
"GO:0015297",
"GO:0022857",
"GO:0016020"
] | [
"antiporter activity",
"transmembrane transporter activity",
"membrane"
] | [
"molecular_function",
"molecular_function",
"cellular_component"
] | 3 | [
"PIRSF",
"PANTHER",
"NCBIFAM"
] | [
"PIRSF005508",
"PTHR43057",
"TIGR00832"
] | [
"Acr3",
"",
"acr3"
] | [
14074,
19022,
14560
] | 3 | [
"GP"
] | [
"GenProp0474"
] | [
"GP:GenProp0474"
] | 1 | [] | 0 | [
"PUB00005662",
"PUB00070752",
"PUB00070753",
"PUB00070754",
"PUB00070755",
"PUB00070756",
"PUB00070758",
"PUB00070759",
"PUB00072662"
] | [
"9234670",
"19494117",
"22102279",
"18088595",
"20530755",
"24291645",
"19039703",
"12949088",
"21447319"
] | [
"Isolation of three contiguous genes, ACR1, ACR2 and ACR3, involved in resistance to arsenic compounds in the yeast Saccharomyces cerevisiae.",
"Properties of arsenite efflux permeases (Acr3) from Alkaliphilus metalliredigens and Corynebacterium glutamicum.",
"Efflux permease CgAcr3-1 of Corynebacterium glutami... | [
1997,
2009,
2012,
2008,
2010,
2014,
2008,
2003,
2011
] | 9 | [
"IPR002657"
] | [] | 1 | 0 | 1 | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
652,
15799,
2141,
434
] | 4 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
1,
1
] | 2 | true | Family | Arsenical-resistance protein Acr3 | Arsenical-resistance protein Acr3 | Arsenical-R_Acr3 | 9 |
IPR004707 | 4,707 | Membrane transport protein MmpL family | MmpL_fam | Family | 3,945 | false | false | This entry represents the MmpL family of membrane transport proteins, which may be involved in lipid transport [ ]. Mycobacterium tuberculosis MMPL10 is required for the biosynthesis of polyacyltrehalose (PAT) and the transport of diacyltrehalose (DAT) and possibly PAT to the cell surface [ ], while MMPL4 is a part of ... | [
"GO:0016020"
] | [
"membrane"
] | [
"cellular_component"
] | 1 | [
"NCBIFAM"
] | [
"TIGR00833"
] | [
"actII"
] | [
3945
] | 1 | [] | [] | [] | 0 | [
"8zkp",
"8zkq",
"9b43",
"9b46",
"9dp6",
"9mvz",
"9mw0",
"9mx0"
] | 8 | [
"PUB00007714",
"PUB00066028",
"PUB00077564"
] | [
"10694977",
"23431276",
"25124040"
] | [
"Analysis of the proteome of Mycobacterium tuberculosis in silico.",
"Discovery of a Siderophore Export System Essential for Virulence of Mycobacterium tuberculosis.",
"Biosynthesis and translocation of unsulfated acyltrehaloses in Mycobacterium tuberculosis."
] | [
1999,
2013,
2014
] | 3 | [] | [] | 0 | 0 | null | [
"Mycobacteriales"
] | [
3945
] | 1 | [] | [] | 0 | true | Family | Membrane transport protein MmpL family | Membrane transport protein MmpL family | MmpL_fam | 4 |
IPR004708 | 4,708 | Aspartate ammonia-lyase | ApsA | Family | 6,245 | false | false | A number of enzymes, belonging to the lyase class, for which fumarate is a substrate have been shown [ ] to share a short conserved sequence around a methionine which is probably involved in the catalytic activity of this type of enzymes. Aspartate ammonia-lyase catalyses the conversion of aspartate to fumarate. | [
"GO:0008797",
"GO:0006531"
] | [
"aspartate ammonia-lyase activity",
"aspartate metabolic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"NCBIFAM"
] | [
"TIGR00839"
] | [
"aspA"
] | [
6245
] | 1 | [
"EC",
"GP",
"GP",
"METACYC",
"METACYC",
"METACYC"
] | [
"4.3.1.1",
"GenProp1233",
"GenProp1404",
"PWY-8291",
"PWY-8294",
"PWY-8419"
] | [
"EC:4.3.1.1",
"GP:GenProp1233",
"GP:GenProp1404",
"METACYC:PWY-8291",
"METACYC:PWY-8294",
"METACYC:PWY-8419"
] | 6 | [
"1j3u",
"1jsw",
"3r6q",
"3r6v",
"6wng",
"8rj0",
"8rj1"
] | 7 | [
"PUB00000586"
] | [
"3282546"
] | [
"Two biochemically distinct classes of fumarase in Escherichia coli."
] | [
1988
] | 1 | [
"IPR000362"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Eukaryota",
"ecological metagenomes"
] | [
6224,
12,
9
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Aspartate ammonia-lyase | Aspartate ammonia-lyase | ApsA | 7 |
IPR004709 | 4,709 | Na+/H+ exchanger | NaH_exchanger | Family | 24,164 | false | false | Sodium proton exchangers (NHEs) constitute a large family of integral membrane protein transporters that are responsible for the counter-transport of protons and sodium ions across lipid bilayers [ , ]. These proteins are found in organisms across all domains of life. In archaea, bacteria, yeast and plants, these excha... | [
"GO:0015385",
"GO:0006814",
"GO:0006885",
"GO:0055085",
"GO:0016020"
] | [
"sodium:proton antiporter activity",
"sodium ion transport",
"regulation of pH",
"transmembrane transport",
"membrane"
] | [
"molecular_function",
"biological_process",
"biological_process",
"biological_process",
"cellular_component"
] | 5 | [
"PRINTS",
"NCBIFAM"
] | [
"PR01084",
"TIGR00840"
] | [
"NAHEXCHNGR",
"b_cpa1"
] | [
23235,
19696
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-2160916",
"R-BTA-425986",
"R-CEL-2160916",
"R-CEL-425986",
"R-DDI-425986",
"R-HSA-2160916",
"R-HSA-425986",
"R-HSA-5619052",
"R-HSA-5619092",
"R-MMU-2160916",
"R-MMU-425986",
"R-RNO-2160916",
"R-RNO-425986",
"R-SCE-425986",
"R-SPO-425986"
] | [
"REACTOME:R-BTA-2160916",
"REACTOME:R-BTA-425986",
"REACTOME:R-CEL-2160916",
"REACTOME:R-CEL-425986",
"REACTOME:R-DDI-425986",
"REACTOME:R-HSA-2160916",
"REACTOME:R-HSA-425986",
"REACTOME:R-HSA-5619052",
"REACTOME:R-HSA-5619092",
"REACTOME:R-MMU-2160916",
"REACTOME:R-MMU-425986",
"REACTOME:R-R... | 15 | [
"1y4e",
"6z3y",
"6z3z",
"7dsv",
"7dsw",
"7dsx",
"7x2u",
"8pvr",
"8pxb"
] | 9 | [
"PUB00001715",
"PUB00002996",
"PUB00003039",
"PUB00044828",
"PUB00044829",
"PUB00044830",
"PUB00044831",
"PUB00044832",
"PUB00044833",
"PUB00044834"
] | [
"9537504",
"9278382",
"9507001",
"12027219",
"12502567",
"16734752",
"17071327",
"16513813",
"11187762",
"17218973"
] | [
"Comparative molecular analysis of Na+/H+ exchangers: a unified model for Na+/H+ antiport?",
"Na+/H+ exchangers of mammalian cells.",
"Identification of a mitochondrial Na+/H+ exchanger.",
"The Na+/H+ exchanger gene family.",
"Multiple modes of regulation of Na+/H+ exchangers.",
"Na+/H+ exchangers and the... | [
1998,
1997,
1998,
2002,
2002,
2006,
2006,
2006,
2000,
2006
] | 10 | [
"IPR018422"
] | [
"IPR001953",
"IPR001970",
"IPR002090"
] | 1 | 3 | 0 | [
"Bacteria",
"Eukaryota",
"Methanobacteriota",
"ecological metagenomes"
] | [
687,
23460,
12,
5
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
22,
15,
26,
28,
27,
24,
1,
16,
34,
1,
1,
48
] | 12 | true | Family | Na+/H+ exchanger | Na+/H+ exchanger | NaH_exchanger | 3 |
IPR004710 | 4,710 | Bile acid:sodium symporter | Bilac:Na_transpt | Family | 23,087 | false | false | Functionally characterised members of the bile Acid:Na+ Symporter (BASS) family catalyse Na+:bile acid symport. These systems have been identified in intestinal, liver and kidney tissues of animals. These symporters exhibit broad specificity, taking up a variety of non bile organic compounds as well as taurocholate and... | [] | [] | [] | 0 | [
"PANTHER",
"NCBIFAM"
] | [
"PTHR10361",
"TIGR00841"
] | [
"",
"bass"
] | [
23077,
1755
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-159418",
"R-HSA-425366",
"R-MMU-159418",
"R-MMU-425366",
"R-RNO-159418",
"R-RNO-425366"
] | [
"REACTOME:R-HSA-159418",
"REACTOME:R-HSA-425366",
"REACTOME:R-MMU-159418",
"REACTOME:R-MMU-425366",
"REACTOME:R-RNO-159418",
"REACTOME:R-RNO-425366"
] | 6 | [
"3zux",
"3zuy",
"4n7w",
"4n7x",
"6lgv",
"6lgy",
"6lgz",
"6lh0",
"6lh1",
"7cyg",
"7cyk",
"7fci",
"7pqg",
"7pqq",
"7vad",
"7vae",
"7vaf",
"7vag",
"7wsi",
"7zyi",
"8hrx",
"8hry",
"8oyf",
"8oyg",
"8rqf",
"8xcd",
"9qzq"
] | 27 | [
"PUB00101344"
] | [
"33222321"
] | [
"Targeting the Four Pillars of Enterohepatic Bile Salt Cycling; Lessons From Genetics and Pharmacology."
] | [
2021
] | 1 | [
"IPR002657"
] | [] | 1 | 0 | 1 | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
366,
12847,
9726,
148
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
18,
1,
7,
3,
9,
15,
10,
19,
20
] | 9 | true | Family | Bile acid:sodium symporter | Bile acid:sodium symporter | Bilac:Na_transpt | 8 |
IPR004711 | 4,711 | Benzoate transporter | Benzoate_Transporter | Family | 9,542 | false | false | Several proteins in this entry have been identified as benzoate transporters [ , , ]. They exhibit about 30% identity to each other and show limited sequence similarity to members of the aromatic acid:H+symporter (AAHS) family of the major facilitator superfamily (MFS). Interestingly, they have different protein struct... | [
"GO:0042925",
"GO:0042919",
"GO:0016020"
] | [
"benzoate transmembrane transporter activity",
"benzoate transport",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PFAM",
"PANTHER",
"NCBIFAM"
] | [
"PF03594",
"PTHR30199",
"TIGR00843"
] | [
"BenE",
"",
"benE"
] | [
9542,
9503,
8644
] | 3 | [] | [] | [] | 0 | [] | 0 | [
"PUB00002151",
"PUB00034647",
"PUB00055028",
"PUB00062359",
"PUB00076709"
] | [
"1885518",
"11053377",
"10839820",
"17322206",
"22588501"
] | [
"Nucleotide sequences of the Acinetobacter calcoaceticus benABC genes for benzoate 1,2-dioxygenase reveal evolutionary relationships among multicomponent oxygenases.",
"BenR, a XylS homologue, regulates three different pathways of aromatic acid degradation in Pseudomonas putida.",
"A functional-phylogenetic cla... | [
1991,
2000,
2000,
2007,
2012
] | 5 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Halobacteriales",
"unclassified sequences"
] | [
9452,
12,
3,
75
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Benzoate transporter | Benzoate transporter | Benzoate_Transporter | 2 |
IPR004712 | 4,712 | Na+/H+ antiporter, fungi | Na+/H+_antiporter_fungi | Family | 5,297 | false | false | This entry represents a group of fungal Na+/H+ antiporters, including Nha1 from budding yeasts and Sod2 (SPAC977.10) from fission yeasts. Nha1 is involved in sodium and potassium efflux through the plasma membrane. It plays a role in the homeostatic regulation of the plasma membrane potential [ ]. Sod2 is a Na+/H+ exch... | [
"GO:0015385",
"GO:0036376",
"GO:0042391",
"GO:0120029",
"GO:0005886"
] | [
"sodium:proton antiporter activity",
"sodium ion export across plasma membrane",
"regulation of membrane potential",
"proton export across plasma membrane",
"plasma membrane"
] | [
"molecular_function",
"biological_process",
"biological_process",
"biological_process",
"cellular_component"
] | 5 | [
"PANTHER"
] | [
"PTHR31382"
] | [
""
] | [
5297
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00071871",
"PUB00076412",
"PUB00076413"
] | [
"16879429",
"19171118",
"23836910"
] | [
"The Na+,K+/H+ -antiporter Nha1 influences the plasma membrane potential of Saccharomyces cerevisiae.",
"Proline 146 is critical to the structure, function and targeting of sod2, the Na+/H+ exchanger of Schizosaccharomyces pombe.",
"Structural and functional analysis of transmembrane segment IV of the salt tole... | [
2006,
2009,
2013
] | 3 | [] | [
"IPR032516"
] | 0 | 1 | 0 | [
"Bacteria",
"Eukaryota",
"Stenosarchaea group",
"ecological metagenomes"
] | [
177,
5092,
25,
3
] | 4 | [
"Caenorhabditis elegans",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
2,
1,
2
] | 4 | true | Family | Na+/H+ antiporter, fungi | Na+/H+ antiporter, fungi | Na+/H+_antiporter_fungi | 6 |
IPR004714 | 4,714 | Cytochrome oxidase maturation protein cbb3-type | Cyt_oxidase_maturation_cbb3 | Family | 8,081 | false | false | Cytochrome cbb3 oxidases are found almost exclusively in Proteobacteria, and represent a distinctive class of proton-pumping respiratory haem-copper oxidases (HCO) that lack many of the key structural features that contribute to the reaction cycle of the intensely studied mitochondrial cytochrome c oxidase (CcO). Expre... | [] | [] | [] | 0 | [
"PFAM",
"PANTHER",
"NCBIFAM"
] | [
"PF03597",
"PTHR41532",
"TIGR00847"
] | [
"FixS",
"",
"ccoS"
] | [
8081,
7350,
7930
] | 3 | [
"GP"
] | [
"GenProp0483"
] | [
"GP:GenProp0483"
] | 1 | [] | 0 | [
"PUB00014947"
] | [
"15100055"
] | [
"The bacterial cytochrome cbb3 oxidases."
] | [
2004
] | 1 | [] | [] | 0 | 0 | null | [
"Achromobacter phage phiAxp-3",
"Bacteria",
"Eukaryota",
"Methanosarcinaceae",
"unclassified sequences"
] | [
1,
7962,
2,
4,
112
] | 5 | [] | [] | 0 | true | Family | Cytochrome oxidase maturation protein cbb3-type | Cytochrome oxidase maturation protein cbb3-type | Cyt_oxidase_maturation_cbb3 | 9 |
IPR004715 | 4,715 | Phosphotransferase system, IIA component fructose subfamily | PTS_IIA_fruc | Domain | 11,414 | false | false | The Man family is unique in several respects among PTS permease families. It is the only PTS family in which members possess a IID protein. It is the only PTS family in which the IIB constituent is phosphorylated on a histidyl rather than a cysteyl residue. Its permease members exhibit broad specificity for a range of ... | [
"GO:0008982",
"GO:0009401",
"GO:0016020"
] | [
"protein-N(PI)-phosphohistidine-sugar phosphotransferase activity",
"phosphoenolpyruvate-dependent sugar phosphotransferase system",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"NCBIFAM"
] | [
"TIGR00848"
] | [
"fruA"
] | [
11414
] | 1 | [
"EC",
"GP",
"GP"
] | [
"2.7.1.202",
"GenProp0119",
"GenProp0693"
] | [
"EC:2.7.1.202",
"GP:GenProp0119",
"GP:GenProp0693"
] | 3 | [] | 0 | [
"PUB00000073",
"PUB00002162",
"PUB00003612",
"PUB00017027",
"PUB00017028"
] | [
"2197982",
"1537788",
"8246840",
"7815935",
"11361063"
] | [
"The bacterial phosphoenolpyruvate: glycose phosphotransferase system.",
"Proposed uniform nomenclature for the proteins and protein domains of the bacterial phosphoenolpyruvate: sugar phosphotransferase system.",
"Phosphoenolpyruvate:carbohydrate phosphotransferase systems of bacteria.",
"The bacterial phosp... | [
1990,
1992,
1993,
1994,
2001
] | 5 | [
"IPR002178"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Eukaryota",
"Methanobacteriota",
"metagenomes"
] | [
11253,
5,
111,
45
] | 4 | [
"Escherichia coli (strain K12)"
] | [
3
] | 1 | true | Domain | Phosphotransferase system, IIA component fructose subfamily | Phosphotransferase system, IIA component fructose subfamily | PTS_IIA_fruc | 5 |
IPR004716 | 4,716 | Phosphotransferase system, glucitol/sorbitol-specific IIA component | PTS_IIA_glucitol/sorbitol-sp | Family | 2,969 | false | false | The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS) [ , ] is a major carbohydrate transport system in bacteria. The PTS catalyses the phosphorylation of incoming sugar substrates and coupled with translocation across the cell membrane, makes the PTS a link between the uptake and metabolism of sugars... | [
"GO:0008982",
"GO:0009401",
"GO:0005737"
] | [
"protein-N(PI)-phosphohistidine-sugar phosphotransferase activity",
"phosphoenolpyruvate-dependent sugar phosphotransferase system",
"cytoplasm"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PFAM",
"PROFILE",
"PANTHER"
] | [
"PF03829",
"PS51097",
"PTHR40398"
] | [
"PTSIIA_gutA",
"PTS_EIIA_TYPE_5",
""
] | [
2968,
2855,
2951
] | 3 | [
"GP",
"PROSITEDOC"
] | [
"GenProp0119",
"PDOC00528"
] | [
"GP:GenProp0119",
"PROSITEDOC:PDOC00528"
] | 2 | [
"2f9h"
] | 1 | [
"PUB00000073",
"PUB00002162",
"PUB00003612",
"PUB00017027",
"PUB00017028"
] | [
"2197982",
"1537788",
"8246840",
"7815935",
"11361063"
] | [
"The bacterial phosphoenolpyruvate: glycose phosphotransferase system.",
"Proposed uniform nomenclature for the proteins and protein domains of the bacterial phosphoenolpyruvate: sugar phosphotransferase system.",
"Phosphoenolpyruvate:carbohydrate phosphotransferase systems of bacteria.",
"The bacterial phosp... | [
1990,
1992,
1993,
1994,
2001
] | 5 | [] | [
"IPR018454"
] | 0 | 1 | 0 | [
"Bacteria",
"Ecdysozoa",
"metagenomes"
] | [
2951,
2,
16
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Phosphotransferase system, glucitol/sorbitol-specific IIA component | Phosphotransferase system, glucitol/sorbitol-specific IIA component | PTS_IIA_glucitol/sorbitol-sp | 4 |
IPR004718 | 4,718 | Phosphotransferase system, mannitol-specific enzyme IIC | PTS_IIC_mtl | Domain | 4,602 | false | false | Bacterial PTS transporters transport and concomitantly phosphorylate their sugar substrates, and typically consist of multiple subunits or protein domains.The Man family is unique in several respects among PTS permease families. It is the only PTS family in which members possess a IID protein. It is the only PTS family... | [
"GO:0008982",
"GO:0009401",
"GO:0016020"
] | [
"protein-N(PI)-phosphohistidine-sugar phosphotransferase activity",
"phosphoenolpyruvate-dependent sugar phosphotransferase system",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"NCBIFAM"
] | [
"TIGR00851"
] | [
"mtlA"
] | [
4602
] | 1 | [
"EC",
"GP"
] | [
"2.7.1.197",
"GenProp0119"
] | [
"EC:2.7.1.197",
"GP:GenProp0119"
] | 2 | [] | 0 | [] | [] | [] | [] | 0 | [
"IPR013014"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Beauveria bassiana D1-5",
"metagenomes"
] | [
4593,
1,
8
] | 3 | [
"Escherichia coli (strain K12)"
] | [
2
] | 1 | true | Domain | Phosphotransferase system, mannitol-specific enzyme IIC | Phosphotransferase system, mannitol-specific enzyme IIC | PTS_IIC_mtl | 5 |
IPR004719 | 4,719 | Phosphotransferase system, maltose/glucose-specific subfamily IIC component | PTS_maltose/Glc_sub_IIC | Domain | 4,246 | false | false | Bacterial PTS transporters transport and concomitantly phosphorylate their sugar substrates, and typically consist of multiple subunits or protein domains. The Glc family includes permeases specific for glucose, N-acetylglucosamine and a large variety of alpha-and beta-glucosides. However, not all b-glucoside PTS perme... | [
"GO:0008982",
"GO:0009401",
"GO:0016020"
] | [
"protein-N(PI)-phosphohistidine-sugar phosphotransferase activity",
"phosphoenolpyruvate-dependent sugar phosphotransferase system",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"NCBIFAM"
] | [
"TIGR00852"
] | [
"pts-Glc"
] | [
4246
] | 1 | [
"EC",
"GP"
] | [
"2.7.1",
"GenProp0119"
] | [
"EC:2.7.1",
"GP:GenProp0119"
] | 2 | [
"8qsr",
"8qst",
"9hnp"
] | 3 | [] | [] | [] | [] | 0 | [
"IPR013013"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Opisthokonta"
] | [
4239,
7
] | 2 | [
"Escherichia coli (strain K12)"
] | [
6
] | 1 | true | Domain | Phosphotransferase system, maltose/glucose-specific subfamily IIC component | Phosphotransferase system, maltose/glucose-specific subfamily IIC component | PTS_maltose/Glc_sub_IIC | 4 |
IPR004720 | 4,720 | Phosphotransferase system, sorbose subfamily IIB component | PTS_IIB_sorbose-sp | Domain | 12,095 | false | false | Bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) transporters transport and concomitantly phosphorylate their sugar substrates, and typically consist of multiple subunits or protein domains [ ]. The Man family is unique in several respects among PTS permease families: It is the only PTS family in wh... | [
"GO:0008982",
"GO:0009401",
"GO:0005737"
] | [
"protein-N(PI)-phosphohistidine-sugar phosphotransferase activity",
"phosphoenolpyruvate-dependent sugar phosphotransferase system",
"cytoplasm"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PFAM",
"PROFILE",
"CDD"
] | [
"PF03830",
"PS51101",
"cd00001"
] | [
"PTSIIB_sorb",
"PTS_EIIB_TYPE_4",
"PTS_IIB_man"
] | [
12091,
12038,
7658
] | 3 | [
"EC",
"GP",
"PROSITEDOC"
] | [
"2.7.1",
"GenProp0119",
"PDOC00795"
] | [
"EC:2.7.1",
"GP:GenProp0119",
"PROSITEDOC:PDOC00795"
] | 3 | [
"1ble",
"1nrz",
"1vsq",
"2jzh",
"2jzn",
"2jzo",
"3eye",
"3lfj",
"3p3v",
"5t5d",
"8yri"
] | 11 | [
"PUB00017031",
"PUB00080194",
"PUB00080195"
] | [
"12662934",
"10393270",
"11532441"
] | [
"Crystal structure of the IIB(Sor) domain of the sorbose permease from Klebsiella pneumoniae solved to 1.75A resolution.",
"Structure/function studies on the bacterial carbohydrate transporters, enzymes II, of the phosphoenolpyruvate-dependent phosphotransferase system.",
"Carbohydrate transporters of the bacte... | [
2003,
1999,
2001
] | 3 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Opisthokonta",
"metagenomes"
] | [
9,
12024,
4,
58
] | 4 | [
"Escherichia coli (strain K12)"
] | [
3
] | 1 | true | Domain | Phosphotransferase system, sorbose subfamily IIB component | Phosphotransferase system, sorbose subfamily IIB component | PTS_IIB_sorbose-sp | 9 |
IPR004721 | 4,721 | Dihydroorotase homodimeric type | DHOdimr | Family | 11,595 | false | false | Dihydroorotase belongs to MEROPS peptidase family M38 (clan MJ), where it is classified as a non-peptidase homologue. DHOase catalyses the third step in the de novo biosynthesis of pyrimidine, the conversion of ureidosuccinic acid (N-carbamoyl-L-aspartate) into dihydroorotate. Dihydroorotase binds a zinc ion which is r... | [
"GO:0004151",
"GO:0019856"
] | [
"dihydroorotase activity",
"pyrimidine nucleobase biosynthetic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"HAMAP",
"PIRSF",
"PANTHER",
"NCBIFAM",
"CDD"
] | [
"MF_00219",
"PIRSF001237",
"PTHR43137",
"TIGR00856",
"cd01294"
] | [
"PyrC_classII",
"DHOdimr",
"",
"pyrC_dimer",
"DHOase"
] | [
10568,
10519,
11584,
10661,
9388
] | 5 | [
"EC",
"GP",
"GP",
"GP",
"METACYC",
"METACYC",
"METACYC"
] | [
"3.5.2.3",
"GenProp0187",
"GenProp1427",
"GenProp1614",
"PWY-5686",
"PWY-7790",
"PWY-7791"
] | [
"EC:3.5.2.3",
"GP:GenProp0187",
"GP:GenProp1427",
"GP:GenProp1614",
"METACYC:PWY-5686",
"METACYC:PWY-7790",
"METACYC:PWY-7791"
] | 7 | [
"1j79",
"1xge",
"2e25",
"2eg6",
"2eg7",
"2eg8",
"2z24",
"2z25",
"2z26",
"2z27",
"2z28",
"2z29",
"2z2a",
"2z2b",
"3jze",
"3mjm",
"3pnu",
"4lfy",
"5vgm",
"6cty",
"6l0a",
"6l0b",
"6l0f",
"6l0g",
"6l0h",
"6l0i",
"6l0j",
"6l0k",
"7ca0",
"7ca1"
] | 30 | [
"PUB00000720",
"PUB00001777",
"PUB00002652",
"PUB00003725",
"PUB00004994"
] | [
"8098212",
"2570735",
"1671037",
"2897615",
"9144792"
] | [
"The evolutionary history of the first three enzymes in pyrimidine biosynthesis.",
"Organization of the yeast URA2 gene: identification of a defective dihydroorotase-like domain in the multifunctional carbamoylphosphate synthetase-aspartate transcarbamylase complex.",
"Dihydroorotase from Escherichia coli. Subs... | [
1993,
1989,
1991,
1988,
1997
] | 5 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
8462,
3009,
124
] | 3 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",
"Zea mays"
] | [
2,
1,
2,
1,
1,
1,
7
] | 7 | true | Family | Dihydroorotase homodimeric type | Dihydroorotase homodimeric type | DHOdimr | 9 |
IPR004722 | 4,722 | Dihydroorotase | DHOase | Family | 20,175 | false | false | Dihydroorotase belongs to MEROPS peptidase family M38 (clan MJ), and includes peptides classified as a non-peptidase homologues. DHOase catalyses the third step in the de novo biosynthesis of pyrimidine, the conversion of ureidosuccinic acid (N-carbamoyl-L-aspartate) into dihydroorotate. Dihydroorotase binds a zinc ion... | [
"GO:0004151",
"GO:0046872",
"GO:0006221"
] | [
"dihydroorotase activity",
"metal ion binding",
"pyrimidine nucleotide biosynthetic process"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"HAMAP",
"HAMAP",
"CDD"
] | [
"MF_00220_A",
"MF_00220_B",
"cd01317"
] | [
"PyrC_classI_A",
"PyrC_classI_B",
"DHOase_IIa"
] | [
642,
10971,
19533
] | 3 | [
"EC",
"GP",
"GP",
"METACYC",
"METACYC",
"METACYC"
] | [
"3.5.2.3",
"GenProp0187",
"GenProp1418",
"PWY-5686",
"PWY-7790",
"PWY-7791"
] | [
"EC:3.5.2.3",
"GP:GenProp0187",
"GP:GenProp1418",
"METACYC:PWY-5686",
"METACYC:PWY-7790",
"METACYC:PWY-7791"
] | 6 | [
"1xrf",
"1xrt",
"2z00",
"3d6n",
"3gri",
"3mpg",
"4bjh",
"4yiw",
"6gdd",
"6gde",
"6gdf",
"7uof"
] | 12 | [
"PUB00000720",
"PUB00001777",
"PUB00002652",
"PUB00003725",
"PUB00004994"
] | [
"8098212",
"2570735",
"1671037",
"2897615",
"9144792"
] | [
"The evolutionary history of the first three enzymes in pyrimidine biosynthesis.",
"Organization of the yeast URA2 gene: identification of a defective dihydroorotase-like domain in the multifunctional carbamoylphosphate synthetase-aspartate transcarbamylase complex.",
"Dihydroorotase from Escherichia coli. Subs... | [
1993,
1989,
1991,
1988,
1997
] | 5 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
634,
19067,
29,
445
] | 4 | [] | [] | 0 | true | Family | Dihydroorotase | Dihydroorotase | DHOase | 1 |
IPR004723 | 4,723 | 8-amino-7-oxononanoate synthase, Archaea/Proteobacteria type | AONS_Archaea/Proteobacteria | Family | 7,535 | false | false | 8-amino-7-oxononanoate synthase (AONS) is a pyridoxal 5'-phosphate-dependent enzyme, which catalyses the decarboxylative condensation of L-alanine with pimeloyl-CoA to form 8(S)-amino-7-oxononanoate. This is the first committed step in biotin biosynthesis [ ]: 6-carboxyhexanoyl-CoA + L-alanine = 8-amino-7-oxononanoate ... | [
"GO:0008710",
"GO:0009102"
] | [
"8-amino-7-oxononanoate synthase activity",
"biotin biosynthetic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"NCBIFAM"
] | [
"TIGR00858"
] | [
"bioF"
] | [
7535
] | 1 | [
"EC",
"GP",
"GP",
"METACYC",
"METACYC",
"METACYC",
"METACYC"
] | [
"2.3.1.47",
"GenProp0036",
"GenProp1577",
"PWY-6519",
"PWY-6578",
"PWY-7147",
"PWY-8203"
] | [
"EC:2.3.1.47",
"GP:GenProp0036",
"GP:GenProp1577",
"METACYC:PWY-6519",
"METACYC:PWY-6578",
"METACYC:PWY-7147",
"METACYC:PWY-8203"
] | 7 | [
"1bs0",
"1dj9",
"1dje",
"2g6w",
"5jay",
"5vnx",
"6onn",
"7poa",
"7pob",
"7poc",
"8dle",
"8s1y"
] | 12 | [
"PUB00023713",
"PUB00024209",
"PUB00040947"
] | [
"9813126",
"10642176",
"16557306"
] | [
"The crystal structure of 8-amino-7-oxononanoate synthase: a bacterial PLP-dependent, acyl-CoA-condensing enzyme.",
"Mechanism of 8-amino-7-oxononanoate synthase: spectroscopic, kinetic, and crystallographic studies.",
"Suicide inhibition of alpha-oxamine synthases: structures of the covalent adducts of 8-amino... | [
1998,
2000,
2006
] | 3 | [] | [
"IPR022834"
] | 0 | 1 | 0 | [
"Archaea",
"Bacteria",
"Myoviridae sp. ctQQg4",
"Opisthokonta",
"metagenomes"
] | [
50,
7421,
1,
2,
61
] | 5 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | 8-amino-7-oxononanoate synthase, Archaea/Proteobacteria type | 8-amino-7-oxononanoate synthase, Archaea/Proteobacteria type | AONS_Archaea/Proteobacteria | 4 |
IPR004724 | 4,724 | Epithelial sodium channel, chordates | ENaC_chordates | Family | 5,497 | false | false | The epithelial Na+ channel (ENaC) proteins consist of sodium channels from animals and has no recognizable homologues in other eukaryotes or bacteria. The vertebrate ENaC proteins from epithelial cells cluster tightly together on the phylogenetic tree: voltage-insensitive ENaC homologues are also found in the brain. El... | [
"GO:0015280",
"GO:0006814",
"GO:0016020"
] | [
"ligand-gated sodium channel activity",
"sodium ion transport",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"NCBIFAM"
] | [
"TIGR00859"
] | [
"ENaC"
] | [
5497
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-2672351",
"R-BTA-9730628",
"R-DRE-2672351",
"R-GGA-2672351",
"R-HSA-2672351",
"R-HSA-9730628",
"R-MMU-2672351",
"R-MMU-9730628",
"R-RNO-2672351",
"R-RNO-9730628"
] | [
"REACTOME:R-BTA-2672351",
"REACTOME:R-BTA-9730628",
"REACTOME:R-DRE-2672351",
"REACTOME:R-GGA-2672351",
"REACTOME:R-HSA-2672351",
"REACTOME:R-HSA-9730628",
"REACTOME:R-MMU-2672351",
"REACTOME:R-MMU-9730628",
"REACTOME:R-RNO-2672351",
"REACTOME:R-RNO-9730628"
] | 10 | [
"2qts",
"3ij4",
"3s3w",
"3s3x",
"4fz0",
"4fz1",
"4ntw",
"4ntx",
"4nty",
"4nyk",
"5wku",
"5wkv",
"5wkx",
"5wky",
"6ave",
"6bqn",
"6cmc",
"6l6i",
"6l6n",
"6l6p",
"6vtk",
"6vtl",
"6wth",
"6x9h",
"7cfs",
"7cft",
"7rnn",
"9blr",
"9btg",
"9btu"
] | 30 | [] | [] | [] | [] | 0 | [
"IPR001873"
] | [] | 1 | 0 | 1 | [
"Vertebrata"
] | [
5497
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
21,
27,
16,
25
] | 4 | true | Family | Epithelial sodium channel, chordates | Epithelial sodium channel, chordates | ENaC_chordates | 4 |
IPR004726 | 4,726 | Degenerin | Deg-1 | Family | 416 | false | false | The Caenorhabditis elegans mec-4 gene encodes a subunit of a candidate mechano-sensitive ion channel that plays a critical role in touch reception [ ]. The product is a mechano-sensory protein (degenerin). At least some of the proteins in this group form part of a mechano-transducing complex for touch sensitivity. Othe... | [
"GO:0005216",
"GO:0006811",
"GO:0016020"
] | [
"monoatomic ion channel activity",
"monoatomic ion transport",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"NCBIFAM"
] | [
"TIGR00867"
] | [
"deg-1"
] | [
416
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-CEL-2672351",
"R-CEL-9730628"
] | [
"REACTOME:R-CEL-2672351",
"REACTOME:R-CEL-9730628"
] | 2 | [] | 0 | [
"PUB00007695"
] | [
"8655580"
] | [
"Sequence and transmembrane topology of MEC-4, an ion channel subunit required for mechanotransduction in Caenorhabditis elegans."
] | [
1996
] | 1 | [
"IPR001873"
] | [] | 1 | 0 | 1 | [
"Nematoda"
] | [
416
] | 1 | [
"Caenorhabditis elegans"
] | [
19
] | 1 | true | Family | Degenerin | Degenerin | Deg-1 | 2 |
IPR004727 | 4,727 | Calcium-activated chloride channel protein, chordata | CLCA_chordata | Family | 1,412 | false | false | This entry represents a family of Ca(2+)-regulated chloride channels (CLCA) which includes bovine, murine and human proteins [ , ]. Each CLCA exhibits a distinct, often overlapping, tissue expression pattern. With the exception of the truncated, secreted protein hCLCA3 [ ], they are synthesized as an approximately 125k... | [
"GO:0005229",
"GO:0006821"
] | [
"intracellularly calcium-gated chloride channel activity",
"chloride transport"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"NCBIFAM"
] | [
"TIGR00868"
] | [
"hCaCC"
] | [
1412
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-2672351",
"R-MMU-2672351"
] | [
"REACTOME:R-HSA-2672351",
"REACTOME:R-MMU-2672351"
] | 2 | [] | 0 | [
"PUB00033867",
"PUB00033868",
"PUB00033869"
] | [
"11071307",
"15987802",
"10095065"
] | [
"Molecular characteristics and functional diversity of CLCA family members.",
"Structure and function of CLCA proteins.",
"Molecular cloning and biochemical characterization of a truncated, secreted member of the human family of Ca2+-activated Cl- channels."
] | [
2000,
2005,
1999
] | 3 | [] | [] | 0 | 0 | null | [
"Vertebrata"
] | [
1412
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
12,
12
] | 3 | true | Family | Calcium-activated chloride channel protein, chordata | Calcium-activated chloride channel protein, chordata | CLCA_chordata | 6 |
IPR004728 | 4,728 | Translocation protein Sec62 | Sec62 | Family | 4,784 | false | false | Members of the NSCC2 family have been sequenced from various yeast, fungal and animals species including Saccharomyces cerevisiae, Drosophila melanogaster and Homo sapiens. These proteins are the Sec62 proteins, believed to be associated with the Sec61 and Sec63 constituents of the general protein secretary systems of ... | [
"GO:0015031",
"GO:0005789"
] | [
"protein transport",
"endoplasmic reticulum membrane"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PFAM",
"PANTHER"
] | [
"PF03839",
"PTHR12443"
] | [
"Sec62",
""
] | [
4589,
4739
] | 2 | [] | [] | [] | 0 | [
"6zzz",
"7aft",
"7kal",
"7kam"
] | 4 | [] | [] | [] | [] | 0 | [] | [
"IPR011553"
] | 0 | 1 | 0 | [
"Eukaryota"
] | [
4784
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
5,
1,
1,
6,
7,
4,
1,
3,
6,
1,
1,
15
] | 12 | true | Family | Translocation protein Sec62 | Translocation protein Sec62 | Sec62 | 3 |
IPR004730 | 4,730 | Transaldolase type 1 | Transaldolase_1 | Family | 12,561 | false | false | Transaldolase ( ) catalyses the reversible transfer of a three-carbon ketol unit from sedoheptulose 7-phosphate to glyceraldehyde 3-phosphate to form erythrose 4-phosphate and fructose 6-phosphate. This enzyme, together with transketolase, provides a link between the glycolytic and pentose-phosphate pathways. Transaldo... | [
"GO:0004801",
"GO:0006098",
"GO:0005737"
] | [
"transaldolase activity",
"pentose-phosphate shunt",
"cytoplasm"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"HAMAP",
"NCBIFAM",
"CDD"
] | [
"MF_00492",
"TIGR00874",
"cd00957"
] | [
"Transaldolase_1",
"talAB",
"Transaldolase_TalAB"
] | [
9417,
11438,
12561
] | 3 | [
"EC",
"GP",
"GP",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"2.2.1.2",
"GenProp0120",
"GenProp1294",
"PWY-1861",
"PWY-5723",
"R-DDI-163754",
"R-DDI-71336",
"R-DME-163754",
"R-DME-71336",
"R-HSA-163754",
"R-HSA-6791055",
"R-HSA-6791462",
"R-HSA-71336",
"R-HSA-8950505",
"R-HSA-9818028",
"R-MMU-163754",
"R-MMU-71336",
"R-RNO-163754",
"R-RNO-... | [
"EC:2.2.1.2",
"GP:GenProp0120",
"GP:GenProp1294",
"METACYC:PWY-1861",
"METACYC:PWY-5723",
"REACTOME:R-DDI-163754",
"REACTOME:R-DDI-71336",
"REACTOME:R-DME-163754",
"REACTOME:R-DME-71336",
"REACTOME:R-HSA-163754",
"REACTOME:R-HSA-6791055",
"REACTOME:R-HSA-6791462",
"REACTOME:R-HSA-71336",
"... | 25 | [
"1f05",
"1i2n",
"1i2o",
"1i2p",
"1i2q",
"1i2r",
"1onr",
"1ucw",
"2cwn",
"2e1d",
"3cq0",
"3cwn",
"3hjz",
"3igx",
"3kof",
"3m16",
"3te9",
"3tk7",
"3tkf",
"3tno",
"3upb",
"4e0c",
"4rz5",
"4rz6",
"4s2b",
"4s2c"
] | 26 | [
"PUB00005649",
"PUB00081753"
] | [
"8109173",
"9343352"
] | [
"Lysine144 is essential for the catalytic activity of Saccharomyces cerevisiae transaldolase.",
"Microbial aldolases and transketolases: new biocatalytic approaches to simple and complex sugars."
] | [
1993,
1997
] | 2 | [
"IPR001585"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
8090,
4426,
45
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
15,
1,
1,
2,
2,
3,
2,
1,
2,
6,
2,
1,
2
] | 13 | true | Family | Transaldolase type 1 | Transaldolase type 1 | Transaldolase_1 | 4 |
IPR004731 | 4,731 | Transaldolase type 3B/Fructose-6-phosphate aldolase | Transaldolase_3B/F6P_aldolase | Family | 10,222 | false | false | This entry includes transaldolases type 3B and fructose-6-phosphate aldolase. They share a high degree of structural similarity and sequence identity. Transaldolase ( ) catalyses the reversible transfer of a three-carbon ketol unit from sedoheptulose 7-phosphate to glyceraldehyde 3-phosphate to form erythrose 4-phospha... | [
"GO:0005975"
] | [
"carbohydrate metabolic process"
] | [
"biological_process"
] | 1 | [
"NCBIFAM"
] | [
"TIGR00875"
] | [
"fsa_talC_mipB"
] | [
10222
] | 1 | [
"EC",
"METACYC",
"METACYC"
] | [
"2.2.1.2",
"PWY-1861",
"PWY-5723"
] | [
"EC:2.2.1.2",
"METACYC:PWY-1861",
"METACYC:PWY-5723"
] | 3 | [
"1l6w",
"1vpx",
"1wx0",
"3r8r",
"3s0c",
"3s1u",
"3s1v",
"3s1w",
"3s1x",
"4rxf",
"4rxg",
"4rz4",
"4s1f",
"4xz9",
"5zol",
"6yr3",
"6yre",
"6yrh",
"6yrm",
"6yrt",
"6ys0",
"7qxf",
"8s7h",
"8s7i",
"9lkp",
"9ll3",
"9ui2",
"9v4b",
"9v4c"
] | 29 | [
"PUB00005649",
"PUB00053971"
] | [
"8109173",
"11120740"
] | [
"Lysine144 is essential for the catalytic activity of Saccharomyces cerevisiae transaldolase.",
"Fructose-6-phosphate aldolase is a novel class I aldolase from Escherichia coli and is related to a novel group of bacterial transaldolases."
] | [
1993,
2001
] | 2 | [
"IPR033919"
] | [
"IPR022999",
"IPR023001"
] | 1 | 2 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
145,
9953,
22,
102
] | 4 | [
"Escherichia coli (strain K12)"
] | [
2
] | 1 | true | Family | Transaldolase type 3B/Fructose-6-phosphate aldolase | Transaldolase type 3B/Fructose-6-phosphate aldolase | Transaldolase_3B/F6P_aldolase | 4 |
IPR004732 | 4,732 | Transaldolase type 2 | Transaldolase_2 | Family | 8,881 | false | false | Transaldolase ( ) catalyses the reversible transfer of a three-carbon ketol unit from sedoheptulose 7-phosphate to glyceraldehyde 3-phosphate to form erythrose 4-phosphate and fructose 6-phosphate. This enzyme, together with transketolase, provides a link between the glycolytic and pentose-phosphate pathways. Transaldo... | [
"GO:0004801",
"GO:0006098",
"GO:0005737"
] | [
"transaldolase activity",
"pentose-phosphate shunt",
"cytoplasm"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"HAMAP",
"PIRSF",
"NCBIFAM",
"CDD"
] | [
"MF_00493",
"PIRSF036915",
"TIGR00876",
"cd00955"
] | [
"Transaldolase_2",
"Trnald_Bac_Plnt",
"tal_mycobact",
"Transaldolase_like"
] | [
8879,
7681,
8355,
8067
] | 4 | [
"EC",
"GP",
"METACYC",
"METACYC"
] | [
"2.2.1.2",
"GenProp0120",
"PWY-1861",
"PWY-5723"
] | [
"EC:2.2.1.2",
"GP:GenProp0120",
"METACYC:PWY-1861",
"METACYC:PWY-5723"
] | 4 | [
"3clm",
"3r5e",
"6zwf",
"6zwh",
"6zwj",
"6zx4",
"7b0l",
"7bbw",
"7bbx",
"7odo",
"7odp",
"7odq",
"7oey"
] | 13 | [
"PUB00005649"
] | [
"8109173"
] | [
"Lysine144 is essential for the catalytic activity of Saccharomyces cerevisiae transaldolase."
] | [
1993
] | 1 | [
"IPR001585"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
7838,
769,
274
] | 3 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
3,
3,
9
] | 3 | true | Family | Transaldolase type 2 | Transaldolase type 2 | Transaldolase_2 | 9 |
IPR004733 | 4,733 | Phosphoribosylformylglycinamidine cyclo-ligase | PurM_cligase | Family | 31,090 | false | false | The purine biosynthetic pathway in prokaryotes enlists eleven enzymes, six of which use ATP. Enzymes 5 and 6 of this pathway, formylglycinamide ribonucleotide (FGAR) amidotransferase (PurL) and aminoimidazole ribonucleotide (AIR) synthetase (PurM or AIRS) utilise ATP to activate the oxygen of an amide within their subs... | [
"GO:0004641",
"GO:0006189"
] | [
"phosphoribosylformylglycinamidine cyclo-ligase activity",
"'de novo' IMP biosynthetic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"HAMAP",
"PANTHER",
"NCBIFAM",
"CDD"
] | [
"MF_00741",
"PTHR10520",
"TIGR00878",
"cd02196"
] | [
"AIRS",
"",
"purM",
"PurM"
] | [
26563,
31075,
27227,
27461
] | 4 | [
"EC",
"GP",
"GP",
"GP",
"GP",
"GP",
"GP",
"GP",
"METACYC",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"6.3.3.1",
"GenProp0110",
"GenProp1216",
"GenProp1284",
"GenProp1406",
"GenProp1592",
"GenProp1628",
"GenProp1689",
"PWY-6121",
"PWY-6122",
"PWY-6277",
"R-BTA-73817",
"R-DDI-73817",
"R-DME-73817",
"R-GGA-419140",
"R-HSA-73817",
"R-MMU-73817",
"R-SCE-73817",
"R-SPO-73817"
] | [
"EC:6.3.3.1",
"GP:GenProp0110",
"GP:GenProp1216",
"GP:GenProp1284",
"GP:GenProp1406",
"GP:GenProp1592",
"GP:GenProp1628",
"GP:GenProp1689",
"METACYC:PWY-6121",
"METACYC:PWY-6122",
"METACYC:PWY-6277",
"REACTOME:R-BTA-73817",
"REACTOME:R-DDI-73817",
"REACTOME:R-DME-73817",
"REACTOME:R-GGA-... | 19 | [
"1cli",
"2btu",
"2v9y",
"2z01",
"3kiz",
"3m84",
"3mdo",
"3p4e",
"3qty",
"5avm",
"5vk4",
"7lvp",
"9jzw",
"9jzx",
"9jzy",
"9jzz",
"9k00",
"9k01",
"9k02",
"9k03",
"9k04",
"9k05",
"9k06"
] | 23 | [
"PUB00014643",
"PUB00074111",
"PUB00080725"
] | [
"10508786",
"3015935",
"10433689"
] | [
"X-ray crystal structure of aminoimidazole ribonucleotide synthetase (PurM), from the Escherichia coli purine biosynthetic pathway at 2.5 A resolution.",
"Nucleotide sequence of the purM gene encoding 5'-phosphoribosyl-5-aminoimidazole synthetase of Escherichia coli K12.",
"Investigation of the ATP binding site... | [
1999,
1986,
1999
] | 3 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
856,
24225,
5289,
59,
661
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
5,
1,
4,
4,
1,
7,
2,
1,
3,
3,
1,
1,
15
] | 13 | true | Family | Phosphoribosylformylglycinamidine cyclo-ligase | Phosphoribosylformylglycinamidine cyclo-ligase | PurM_cligase | 5 |
IPR004736 | 4,736 | MFS transporter, metabolite:H symporter | MHS_symport | Family | 9,312 | false | false | Recent genome-sequencing data and a wealth of biochemical and molecular genetic investigations have revealed the occurrence of dozens of families of primary and secondary transporters. Two such families have been found to occur ubiquitously in all classifications of living organisms. These are the ATP-binding cassette ... | [
"GO:0022857",
"GO:0055085",
"GO:0016020"
] | [
"transmembrane transporter activity",
"transmembrane transport",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"NCBIFAM"
] | [
"TIGR00883"
] | [
"2A0106"
] | [
9312
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00007278",
"PUB00009720",
"PUB00009721",
"PUB00016912",
"PUB00030513",
"PUB00033870",
"PUB00033871",
"PUB00086656"
] | [
"9529885",
"8987357",
"1970645",
"1718953",
"14643666",
"8419306",
"9524262",
"16000740"
] | [
"Major facilitator superfamily.",
"Proton-dependent multidrug efflux systems.",
"Homologous sugar transport proteins in Escherichia coli and their relatives in both prokaryotes and eukaryotes.",
"Cloning and nucleotide sequence of the gene (citA) encoding a citrate carrier from Salmonella typhimurium.",
"So... | [
1998,
1996,
1990,
1991,
2003,
1993,
1998,
2005
] | 8 | [
"IPR005828"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Opisthokonta",
"bioreactor metagenome"
] | [
9303,
8,
1
] | 3 | [
"Escherichia coli (strain K12)"
] | [
5
] | 1 | true | Family | MFS transporter, metabolite:H symporter | MFS transporter, metabolite:H symporter | MHS_symport | 1 |
IPR004737 | 4,737 | Nitrate transporter NarK/NarU-like | NO3_transporter_NarK/NarU-like | Family | 6,946 | false | false | This family represents nitrate/nitrite antiporters in bacteria, fungi, algae and marine diatoms. Nitrate transporters in Escherichia coli are involved in excretion of nitrite produced by the dissimilatory reduction of nitrate. NarK is polytopic membrane protein with 12 transmembrane domains which is involved in nitrate... | [
"GO:0015112",
"GO:0015113",
"GO:0015706",
"GO:0015707",
"GO:0016020"
] | [
"nitrate transmembrane transporter activity",
"nitrite transmembrane transporter activity",
"nitrate transmembrane transport",
"nitrite transport",
"membrane"
] | [
"molecular_function",
"molecular_function",
"biological_process",
"biological_process",
"cellular_component"
] | 5 | [
"NCBIFAM"
] | [
"TIGR00886"
] | [
"2A0108"
] | [
6946
] | 1 | [] | [] | [] | 0 | [
"4iu8",
"4iu9",
"4jr9",
"4jre",
"4u4t",
"4u4v",
"4u4w"
] | 7 | [
"PUB00014835",
"PUB00014836",
"PUB00060973",
"PUB00060974"
] | [
"7934881",
"9508795",
"18691156",
"16391109"
] | [
"NarK is a nitrite-extrusion system involved in anaerobic nitrate respiration by Escherichia coli.",
"Mapping of the nitrate-assimilation gene cluster (crnA-niiA-niaD) and characterization of the nitrite reductase gene (niiA) in the opportunistic fungal pathogen Aspergillus fumigatus.",
"A single channel for ni... | [
1994,
1998,
2009,
2006
] | 4 | [
"IPR044772"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
5428,
1494,
24
] | 3 | [
"Escherichia coli (strain K12)",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
2,
1
] | 2 | true | Family | Nitrate transporter NarK/NarU-like | Nitrate transporter NarK/NarU-like | NO3_transporter_NarK/NarU-like | 3 |
IPR004738 | 4,738 | Phosphate permease | Phos_permease | Family | 5,406 | false | false | In yeast the high-affinity transporter for external inorganic phosphate is not essential since a constitutive, low-affinity transporter exists. The induction of the yeast protein is depressed by phosphate starvation. | [
"GO:0005315",
"GO:0006817",
"GO:0016020"
] | [
"phosphate transmembrane transporter activity",
"phosphate ion transport",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"NCBIFAM"
] | [
"TIGR00887"
] | [
"2A0109"
] | [
5406
] | 1 | [] | [] | [] | 0 | [
"9kmq",
"9kou"
] | 2 | [] | [] | [] | [] | 0 | [
"IPR005828"
] | [] | 1 | 0 | 1 | [
"Eukaryota"
] | [
5406
] | 1 | [
"Arabidopsis thaliana",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",
"Zea mays"
] | [
27,
1,
12,
1,
2,
27
] | 6 | true | Family | Phosphate permease | Phosphate permease | Phos_permease | 7 |
IPR004739 | 4,739 | GMP synthase, glutamine amidotransferase | GMP_synth_GATase | Domain | 30,221 | false | false | This entry represents the N-terminal domain of bacterial GMP synthase [glutamine-hydrolyzing] and similar sequences found in all cellular organisms. This domain covers the whole protein length in some archaeal members of this group. GMP synthase catalyses the synthesis of GMP from XMP [ , ]. ATP + xanthosine 5'-phospha... | [
"GO:0003922",
"GO:0005524",
"GO:0006177"
] | [
"GMP synthase (glutamine-hydrolyzing) activity",
"ATP binding",
"GMP biosynthetic process"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"NCBIFAM",
"CDD"
] | [
"TIGR00888",
"cd01742"
] | [
"guaA_Nterm",
"GATase1_GMP_Synthase"
] | [
29880,
30058
] | 2 | [
"EC",
"GP",
"GP",
"GP",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"6.3.5.2",
"GenProp0696",
"GenProp0697",
"GenProp1650",
"PWY-7221",
"R-CEL-73817",
"R-CEL-9748787",
"R-DDI-73817",
"R-DDI-9748787",
"R-HSA-73817",
"R-HSA-9748787",
"R-MMU-73817",
"R-MMU-9748787",
"R-PFA-73817",
"R-PFA-9748787",
"R-RNO-73817",
"R-RNO-9748787",
"R-SCE-73817",
"R-SC... | [
"EC:6.3.5.2",
"GP:GenProp0696",
"GP:GenProp0697",
"GP:GenProp1650",
"METACYC:PWY-7221",
"REACTOME:R-CEL-73817",
"REACTOME:R-CEL-9748787",
"REACTOME:R-DDI-73817",
"REACTOME:R-DDI-9748787",
"REACTOME:R-HSA-73817",
"REACTOME:R-HSA-9748787",
"REACTOME:R-MMU-73817",
"REACTOME:R-MMU-9748787",
"R... | 21 | [
"1gpm",
"1wl8",
"2a9v",
"2d7j",
"2lxn",
"2vpi",
"2vxo",
"2ywb",
"2ywc",
"3tqi",
"3uow",
"4wim",
"4win",
"4wio",
"5tw7",
"7d40",
"7d95",
"7d96",
"7d97",
"7mo6",
"7sbc",
"7yc6",
"7zu9",
"8gr1",
"8gr3"
] | 25 | [
"PUB00002062",
"PUB00002406",
"PUB00003933"
] | [
"3298209",
"6086650",
"8548458"
] | [
"Structural role for a conserved region in the CTP synthetase glutamine amide transfer domain.",
"Sequence of the small subunit of yeast carbamyl phosphate synthetase and identification of its catalytic domain.",
"The crystal structure of GMP synthetase reveals a novel catalytic triad and is a structural paradi... | [
1987,
1984,
1996
] | 3 | [
"IPR017926"
] | [] | 1 | 0 | 1 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
832,
24215,
4682,
4,
488
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
6,
1,
1,
3,
1,
4,
2,
1,
3,
7,
1,
1,
3
] | 13 | true | Domain | GMP synthase, glutamine amidotransferase | GMP synthase, glutamine amidotransferase | GMP_synth_GATase | 3 |
IPR004740 | 4,740 | Nucleoside:H+ symporter | Nuc_H_symport | Family | 6,707 | false | false | This family of proteins transports nucleosides at a high affinity. The transport mechanism is driven by proton motive force. This family includes nucleoside permease (NupG) and xanthosine permease (XapB) from Escherichia coli. | [
"GO:0005337",
"GO:0015858",
"GO:0016020"
] | [
"nucleoside transmembrane transporter activity",
"nucleoside transport",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PFAM",
"NCBIFAM"
] | [
"PF03825",
"TIGR00889"
] | [
"Nuc_H_symport",
"2A0110"
] | [
6707,
3589
] | 2 | [] | [] | [] | 0 | [
"7dl9",
"7dla",
"8zoj"
] | 3 | [] | [] | [] | [] | 0 | [] | [
"IPR033667"
] | 0 | 1 | 0 | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
6586,
15,
106
] | 3 | [
"Escherichia coli (strain K12)"
] | [
3
] | 1 | true | Family | Nucleoside:H+ symporter | Nucleoside:H+ symporter | Nuc_H_symport | 1 |
IPR004741 | 4,741 | Oxalate/formate antiporter family transporter | Oxa_For_antiport_fam_transptr | Family | 524 | false | false | This subfamily belongs to the major facilitator family. Members include the oxalate/formate antiporter of Oxalobacter formigenes, where one substrate is decarboxylated in the cytosol into the other to consume a proton and drive an ion gradient. | [
"GO:0022857",
"GO:0055085",
"GO:0016020"
] | [
"transmembrane transporter activity",
"transmembrane transport",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"NCBIFAM"
] | [
"TIGR00890"
] | [
"2A0111"
] | [
524
] | 1 | [] | [] | [] | 0 | [
"8hpj",
"8hpk"
] | 2 | [] | [] | [] | [] | 0 | [
"IPR050327"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Opisthokonta",
"Thermoprotei",
"organismal metagenomes"
] | [
484,
18,
19,
3
] | 4 | [
"Caenorhabditis elegans",
"Escherichia coli (strain K12)"
] | [
2,
1
] | 2 | true | Family | Oxalate/formate antiporter family transporter | Oxalate/formate antiporter family transporter | Oxa_For_antiport_fam_transptr | 9 |
IPR004742 | 4,742 | Sialic acid transporter | SA_transporter | Family | 950 | false | false | This entry represents sialic acid transporters. The sugar transporters belong to a family of membrane proteins responsible for the transport of various sugars in a wide range of prokaryotic and eukaryotic organisms [ ]. These integral membrane proteins are predicted to comprise twelve membrane spanning domains. It is l... | [
"GO:0015136",
"GO:0015739",
"GO:0016020"
] | [
"sialic acid transmembrane transporter activity",
"sialic acid transport",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"HAMAP",
"NCBIFAM"
] | [
"MF_01238",
"TIGR00891"
] | [
"MFS_NanT",
"2A0112"
] | [
840,
874
] | 2 | [] | [] | [] | 0 | [] | 0 | [
"PUB00002464",
"PUB00003999",
"PUB00005096"
] | [
"3170580",
"3543693",
"3839598"
] | [
"Evidence for a family of human glucose transporter-like proteins. Sequence and gene localization of a protein expressed in fetal skeletal muscle and other tissues.",
"Mammalian and bacterial sugar transport proteins are homologous.",
"Sequence and structure of a human glucose transporter."
] | [
1988,
1987,
1985
] | 3 | [
"IPR011701"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Saccharomycetaceae"
] | [
928,
22
] | 2 | [
"Escherichia coli (strain K12)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
1,
1
] | 2 | true | Family | Sialic acid transporter | Sialic acid transporter | SA_transporter | 7 |
IPR004743 | 4,743 | Monocarboxylate transporter | MCT | Family | 4,352 | false | false | Monocarboxylate transporters (MCTs) catalyse the proton-linked transport of monocarboxylates such as L-lactate, pyruvate, and the ketone bodies across the plasma membrane [ , ]. All of the MCT family (also known as SLC16 solute carrier family) members share conserved sequence motifs. They are are predicted to have 12-t... | [
"GO:0008028",
"GO:0015718",
"GO:0016020"
] | [
"monocarboxylic acid transmembrane transporter activity",
"monocarboxylic acid transport",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"NCBIFAM"
] | [
"TIGR00892"
] | [
"2A0113"
] | [
4352
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-210991",
"R-BTA-433692",
"R-BTA-9749641",
"R-GGA-210991",
"R-GGA-373920",
"R-GGA-433692",
"R-HSA-210991",
"R-HSA-433692",
"R-HSA-5619070",
"R-HSA-9749641",
"R-MMU-210991",
"R-MMU-433692",
"R-MMU-9749641",
"R-RNO-210991",
"R-RNO-433692",
"R-RNO-9749641"
] | [
"REACTOME:R-BTA-210991",
"REACTOME:R-BTA-433692",
"REACTOME:R-BTA-9749641",
"REACTOME:R-GGA-210991",
"REACTOME:R-GGA-373920",
"REACTOME:R-GGA-433692",
"REACTOME:R-HSA-210991",
"REACTOME:R-HSA-433692",
"REACTOME:R-HSA-5619070",
"REACTOME:R-HSA-9749641",
"REACTOME:R-MMU-210991",
"REACTOME:R-MMU-... | 16 | [
"6lyy",
"6lz0",
"7bp3",
"7cko",
"7ckr",
"7da5",
"7y1q",
"7yr5"
] | 8 | [
"PUB00000552",
"PUB00073943",
"PUB00073947"
] | [
"9425115",
"22131303",
"22407107"
] | [
"Cloning and sequencing of four new mammalian monocarboxylate transporter (MCT) homologues confirms the existence of a transporter family with an ancient past.",
"The monocarboxylate transporter family--Structure and functional characterization.",
"Role of monocarboxylate transporters in human cancers: state of... | [
1998,
2012,
2012
] | 3 | [
"IPR050327"
] | [] | 1 | 0 | 1 | [
"Eukaryota"
] | [
4352
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
27,
12,
14,
7
] | 4 | true | Family | Monocarboxylate transporter | Monocarboxylate transporter | MCT | 1 |
IPR004745 | 4,745 | Na-dependent inorganic phosphate cotransporter | Pi_cotranspt | Family | 139 | false | false | Na(+)-dependent inorganic phosphate cotransporter proteins belong to this group. The mammalian proteins are important for the resorption of phosphate by the kidney and may be involved in actively transporting phosphate into cells via sodium ion cotransport in the renal brush border membrane. | [
"GO:0005315",
"GO:0035435",
"GO:0016020"
] | [
"phosphate transmembrane transporter activity",
"phosphate ion transmembrane transport",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"NCBIFAM"
] | [
"TIGR00894"
] | [
"2A0114euk"
] | [
139
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DME-2672351",
"R-DME-428643",
"R-HSA-428643",
"R-MMU-428643",
"R-RNO-428643"
] | [
"REACTOME:R-DME-2672351",
"REACTOME:R-DME-428643",
"REACTOME:R-HSA-428643",
"REACTOME:R-MMU-428643",
"REACTOME:R-RNO-428643"
] | 5 | [] | 0 | [] | [] | [] | [] | 0 | [
"IPR011701"
] | [] | 1 | 0 | 1 | [
"Bilateria"
] | [
139
] | 1 | [
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
5,
1,
2,
4
] | 4 | true | Family | Na-dependent inorganic phosphate cotransporter | Na-dependent inorganic phosphate cotransporter | Pi_cotranspt | 1 |
IPR004746 | 4,746 | Major facilitator superfamily, aromatic acid:H+ symporter family | MFS_AAHS | Family | 1,494 | false | false | The aromatic acid:H+ symporter family (AAHS) is classified as family 15 of the major facilitator superfamily (MFS) [ ]. Members of the AAHS family show fairly uniform sizes (418 to 460 residues). They transport a variety of aromatic acids as well as cis,cis-muconate [ ]. 4-hydroxybenzoate transporter (PcaK Ppu), a memb... | [
"GO:0022857",
"GO:0055085",
"GO:0016020"
] | [
"transmembrane transporter activity",
"transmembrane transport",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"NCBIFAM"
] | [
"TIGR00895"
] | [
"2A0115"
] | [
1494
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00007278",
"PUB00018323",
"PUB00019527",
"PUB00055026",
"PUB00055028"
] | [
"9529885",
"7961399",
"9294455",
"9294456",
"10839820"
] | [
"Major facilitator superfamily.",
"Identification of the pcaRKF gene cluster from Pseudomonas putida: involvement in chemotaxis, biodegradation, and transport of 4-hydroxybenzoate.",
"mucK, a gene in Acinetobacter calcoaceticus ADP1 (BD413), encodes the ability to grow on exogenous cis,cis-muconate as the sole ... | [
1998,
1994,
1997,
1997,
2000
] | 5 | [
"IPR011701"
] | [] | 1 | 0 | 1 | [
"Bacteria"
] | [
1494
] | 1 | [] | [] | 0 | true | Family | Major facilitator superfamily, aromatic acid:H+ symporter family | Major facilitator superfamily, aromatic acid:H+ symporter family | MFS_AAHS | 2 |
IPR004747 | 4,747 | Cyanate transport protein CynX-like | CynX-like | Family | 2,787 | false | false | This entry includes the cyanate transport protein CynX and 2-nitroimidazole transporter yeaN from E. coli. Protein yeaN is involved in efflux of 2-nitroimidazole [ ]. | [
"GO:0016020"
] | [
"membrane"
] | [
"cellular_component"
] | 1 | [
"NCBIFAM"
] | [
"TIGR00896"
] | [
"CynX"
] | [
2787
] | 1 | [
"GP"
] | [
"GenProp1072"
] | [
"GP:GenProp1072"
] | 1 | [] | 0 | [
"PUB00008197",
"PUB00062336",
"PUB00062337",
"PUB00076415"
] | [
"3049588",
"2094285",
"8444806",
"25790494"
] | [
"Characterization of the cyn operon in Escherichia coli K12.",
"The cyanase operon and cyanate metabolism.",
"A physiological role for cyanate-induced carbonic anhydrase in Escherichia coli.",
"Role of transcription factor NimR (YeaM) in sensitivity control of Escherichia coli to 2-nitroimidazole."
] | [
1988,
1990,
1993,
2015
] | 4 | [
"IPR011701"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Trichuris trichiura"
] | [
2786,
1
] | 2 | [
"Escherichia coli (strain K12)"
] | [
2
] | 1 | true | Family | Cyanate transport protein CynX-like | Cyanate transport protein CynX-like | CynX-like | 6 |
IPR004748 | 4,748 | Polyol permease-like | Polyol_permease-like | Family | 2,303 | false | false | This entry represents a group of related bacterial proteins, including known or predicted polyol transporters. The best characterised of these proteins are DalT and RbtT from Klebsiella pneumoniae, which tranpsort D-arabinatol and ribotol respectively. Like other members of the Major Facilitator Superfamily (MFS), DalT... | [
"GO:0022857",
"GO:0055085",
"GO:0016020"
] | [
"transmembrane transporter activity",
"transmembrane transport",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"NCBIFAM",
"CDD"
] | [
"TIGR00897",
"cd17337"
] | [
"2A0118",
"MFS_CsbX"
] | [
2303,
2152
] | 2 | [] | [] | [] | 0 | [] | 0 | [
"PUB00007926",
"PUB00034479",
"PUB00075603",
"PUB00094019",
"PUB00096970",
"PUB00097058",
"PUB00102173",
"PUB00102174",
"PUB00106858"
] | [
"9639934",
"9324246",
"26098515",
"23530251",
"26758938",
"23403214",
"18537473",
"26234418",
"9099855"
] | [
"Genes for D-arabinitol and ribitol catabolism from Klebsiella pneumoniae.",
"Substrate recognition domains as revealed by active hybrids between the D-arabinitol and ribitol transporters from Klebsiella pneumoniae.",
"Structural Biology of the Major Facilitator Superfamily Transporters.",
"Evolutionary mix-a... | [
1998,
1997,
2015,
2013,
2016,
2013,
2008,
2015,
1997
] | 9 | [
"IPR011701"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Beauveria bassiana D1-5"
] | [
2302,
1
] | 2 | [] | [] | 0 | true | Family | Polyol permease-like | Polyol permease-like | Polyol_permease-like | 8 |
IPR004749 | 4,749 | Organic cation transport protein/SVOP | Orgcat_transp/SVOP | Family | 3,686 | false | false | This family consists of organic cation transporters, members of the solute carrier family 22 (SLC22) [ ], and also includes transporter-like protein SVOP (synaptic vesicle 2-related protein), which has similarity to the SLC22 family [ ]. SVOP may contribute to neuronal development, but its role is not clear and no tran... | [
"GO:0016020"
] | [
"membrane"
] | [
"cellular_component"
] | 1 | [
"NCBIFAM"
] | [
"TIGR00898"
] | [
"2A0119"
] | [
3686
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-112311",
"R-BTA-181430",
"R-BTA-2161517",
"R-BTA-442660",
"R-BTA-549127",
"R-BTA-9793528",
"R-HSA-112311",
"R-HSA-181430",
"R-HSA-200425",
"R-HSA-2161517",
"R-HSA-442660",
"R-HSA-549127",
"R-HSA-561048",
"R-HSA-5619053",
"R-HSA-9749641",
"R-HSA-9793528",
"R-MMU-112311",
"R-M... | [
"REACTOME:R-BTA-112311",
"REACTOME:R-BTA-181430",
"REACTOME:R-BTA-2161517",
"REACTOME:R-BTA-442660",
"REACTOME:R-BTA-549127",
"REACTOME:R-BTA-9793528",
"REACTOME:R-HSA-112311",
"REACTOME:R-HSA-181430",
"REACTOME:R-HSA-200425",
"REACTOME:R-HSA-2161517",
"REACTOME:R-HSA-442660",
"REACTOME:R-HSA-... | 41 | [
"7zh0",
"7zh6",
"7zha",
"8bvr",
"8bvs",
"8bvt",
"8bw7",
"8et6",
"8et7",
"8et8",
"8et9",
"8jts",
"8jtt",
"8jtv",
"8jtw",
"8jtx",
"8jty",
"8jtz",
"8ju0",
"8omu",
"8sc1",
"8sc2",
"8sc3",
"8sc4",
"8sc6",
"8sdu",
"8sdy",
"8sdz",
"9j02",
"9j04",
"9j06",
"9kkk"... | 40 | [
"PUB00076666",
"PUB00076667",
"PUB00076668",
"PUB00076669",
"PUB00101350",
"PUB00101351"
] | [
"17714910",
"25540139",
"23894296",
"9801366",
"14586168",
"11306713"
] | [
"Identification of six putative human transporters with structural similarity to the drug transporter SLC22 family.",
"The organic anion transporter (OAT) family: a systems biology perspective.",
"Loss of the SV2-like protein SVOP produces no apparent deficits in laboratory mice.",
"SVOP, an evolutionarily co... | [
2007,
2015,
2013,
1998,
2003,
2001
] | 6 | [
"IPR005828"
] | [
"IPR045915"
] | 1 | 1 | 0 | [
"Bilateria"
] | [
3686
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
2,
16,
16,
25
] | 5 | true | Family | Organic cation transport protein/SVOP | Organic cation transport protein/SVOP | Orgcat_transp/SVOP | 1 |
IPR004750 | 4,750 | Sugar efflux | Sugar_efflux | Family | 1,743 | false | false | This family of proteins is an efflux system for lactose, glucose, aromatic glucosides and galactosides, cellobiose, maltose, a-methyl glucoside and other sugar compounds. They are found in both Gram-negative and Gram-positive bacteria. | [
"GO:0005351",
"GO:0008643",
"GO:0016020"
] | [
"carbohydrate:proton symporter activity",
"carbohydrate transport",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"NCBIFAM"
] | [
"TIGR00899"
] | [
"2A0120"
] | [
1743
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [
"IPR011701"
] | [] | 1 | 0 | 1 | [
"Opisthokonta",
"Pseudomonadota",
"human gut metagenome"
] | [
2,
1740,
1
] | 3 | [
"Escherichia coli (strain K12)"
] | [
3
] | 1 | true | Family | Sugar efflux | Sugar efflux | Sugar_efflux | 7 |
IPR004752 | 4,752 | AmpG-like permease/Acetyl-coenzyme A transporter 1 | AmpG_permease/AT-1 | Family | 19,911 | false | false | This family consists of AmpG-like permease and acetyl-coenzyme A transporter 1 (AT-1). AT-1 is a probable acetyl-CoA transporter necessary for O-acetylation of gangliosides [ ]. The signal transducer encoded by AmpG is essential for induction of chromosomal AmpC beta-lactamase in Escherichia coli by beta-lactam antibio... | [
"GO:0016020"
] | [
"membrane"
] | [
"cellular_component"
] | 1 | [
"PANTHER"
] | [
"PTHR12778"
] | [
""
] | [
19911
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-425397",
"R-HSA-5619061",
"R-MMU-425397",
"R-RNO-425397",
"R-SCE-425397",
"R-SPO-425397"
] | [
"REACTOME:R-HSA-425397",
"REACTOME:R-HSA-5619061",
"REACTOME:R-MMU-425397",
"REACTOME:R-RNO-425397",
"REACTOME:R-SCE-425397",
"REACTOME:R-SPO-425397"
] | 6 | [
"8zbb",
"8zgz",
"8zke",
"9c3f",
"9j9z",
"9m0s"
] | 6 | [
"PUB00007028",
"PUB00056020"
] | [
"7773404",
"10570973"
] | [
"The signal transducer encoded by ampG is essential for induction of chromosomal AmpC beta-lactamase in Escherichia coli by beta-lactam antibiotics and 'unspecific' inducers.",
"Cloning and characterization of a putative mouse acetyl-CoA transporter cDNA."
] | [
1995,
1999
] | 2 | [
"IPR011701"
] | [
"IPR024371"
] | 1 | 1 | 0 | [
"Bacteria",
"Eukaryota",
"Methanobacteriati",
"unclassified sequences"
] | [
14026,
5659,
5,
221
] | 4 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
... | [
5,
4,
3,
1,
10,
5,
1,
4,
2,
1
] | 10 | true | Family | AmpG-like permease/Acetyl-coenzyme A transporter 1 | AmpG-like permease/Acetyl-coenzyme A transporter 1 | AmpG_permease/AT-1 | 7 |
IPR004753 | 4,753 | Cell shape determining protein MreB | MreB | Family | 27,491 | false | false | MreB proteins are essential for cell-shape maintenance and cell morphogenesis in most non-spherical bacteria [ , ]. Most rod-shaped or non-spherical bacteria possess at least one mreB homologue. In Bacillus subtilis, sidewall elongation during vegetative growth is controlled by three MreB isoforms: MreB, Mbl and MreBH ... | [
"GO:0000902"
] | [
"cell morphogenesis"
] | [
"biological_process"
] | 1 | [
"HAMAP",
"PRINTS",
"NCBIFAM",
"CDD"
] | [
"MF_02207",
"PR01652",
"TIGR00904",
"cd10225"
] | [
"MreB",
"SHAPEPROTEIN",
"mreB",
"ASKHA_NBD_MreB-like"
] | [
26240,
27391,
24238,
25656
] | 4 | [
"GP"
] | [
"GenProp0166"
] | [
"GP:GenProp0166"
] | 1 | [
"1jce",
"1jcf",
"1jcg",
"2wus",
"4cze",
"4czf",
"4czg",
"4czh",
"4czi",
"4czj",
"4czk",
"4czl",
"4czm",
"7bvy",
"7bvz",
"7e1c",
"7e1g",
"7zpt",
"7zpu",
"8aam",
"8ab4",
"8azg"
] | 22 | [
"PUB00080600",
"PUB00080601",
"PUB00080602",
"PUB00080603",
"PUB00080604",
"PUB00080605",
"PUB00080606",
"PUB00080607",
"PUB00127205",
"PUB00156842"
] | [
"22652894",
"17158703",
"19659933",
"12809607",
"25578957",
"23826965",
"17880425",
"15922599",
"21636745",
"24843005"
] | [
"The actin-like MreB proteins in Bacillus subtilis: a new turn.",
"The bacterial actin-like cytoskeleton.",
"Partial functional redundancy of MreB isoforms, MreB, Mbl and MreBH, in cell morphogenesis of Bacillus subtilis.",
"Control of cell morphogenesis in bacteria: two distinct ways to make a rod-shaped cel... | [
2012,
2006,
2009,
2003,
2015,
2013,
2007,
2005,
2011,
2014
] | 10 | [
"IPR056546"
] | [] | 1 | 0 | 1 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Siphoviridae sp. ctgu013",
"unclassified sequences"
] | [
52,
26711,
73,
1,
654
] | 5 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Cell shape determining protein MreB | Cell shape determining protein MreB | MreB | 9 |
IPR004754 | 4,754 | Amino acid antiporter | Amino_acid_antiprt | Family | 7,697 | false | false | Amino acid permeases are integral membrane proteins involved in the transport of amino acids into the cell. A number of such proteins have been found to be evolutionary related [ , , ]. These proteins seem to contain up to 12 transmembrane segments. The best conserved region in this family is located in the second tran... | [
"GO:0006865",
"GO:0016020"
] | [
"amino acid transport",
"membrane"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"NCBIFAM"
] | [
"TIGR00905"
] | [
"2A0302"
] | [
7697
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00001779",
"PUB00003402",
"PUB00005006"
] | [
"2687114",
"3146645",
"8382989"
] | [
"Nucleotide sequence of the Saccharomyces cerevisiae PUT4 proline-permease-encoding gene: similarities between CAN1, HIP1 and PUT4 permeases.",
"Evolutionary relationship and secondary structure predictions in four transport proteins of Saccharomyces cerevisiae.",
"Mammalian integral membrane receptors are homo... | [
1989,
1988,
1993
] | 3 | [
"IPR002293"
] | [
"IPR022461"
] | 1 | 1 | 0 | [
"Bacteria",
"Opisthokonta",
"metagenomes"
] | [
7689,
6,
2
] | 3 | [
"Escherichia coli (strain K12)"
] | [
3
] | 1 | true | Family | Amino acid antiporter | Amino acid antiporter | Amino_acid_antiprt | 3 |
IPR004755 | 4,755 | Cationic amino acid transport permease | Cat_AA_permease | Family | 3,954 | false | false | Amino acid permeases are integral membrane proteins involved in the transport of amino acids into the cell. A number of such proteins have been found to be evolutionary related [ , , ]. These proteins seem to contain up to 12 transmembrane segments. The best conserved region in this family is located in the second tran... | [
"GO:0006865",
"GO:0016020"
] | [
"amino acid transport",
"membrane"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"NCBIFAM"
] | [
"TIGR00906"
] | [
"2A0303"
] | [
3954
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DRE-352230",
"R-HSA-352230",
"R-MMU-352230",
"R-RNO-352230"
] | [
"REACTOME:R-DRE-352230",
"REACTOME:R-HSA-352230",
"REACTOME:R-MMU-352230",
"REACTOME:R-RNO-352230"
] | 4 | [
"9fqt",
"9fqu",
"9fqv",
"9fqw"
] | 4 | [
"PUB00001779",
"PUB00003402",
"PUB00005006"
] | [
"2687114",
"3146645",
"8382989"
] | [
"Nucleotide sequence of the Saccharomyces cerevisiae PUT4 proline-permease-encoding gene: similarities between CAN1, HIP1 and PUT4 permeases.",
"Evolutionary relationship and secondary structure predictions in four transport proteins of Saccharomyces cerevisiae.",
"Mammalian integral membrane receptors are homo... | [
1989,
1988,
1993
] | 3 | [
"IPR002293"
] | [] | 1 | 0 | 1 | [
"Bilateria"
] | [
3954
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
20,
7,
13,
11
] | 5 | true | Family | Cationic amino acid transport permease | Cationic amino acid transport permease | Cat_AA_permease | 5 |
IPR004756 | 4,756 | Amino acid permease subfamily | AA_permease | Family | 884 | false | false | Amino acid permeases are integral membrane proteins involved in the transport of amino acids into the cell. A number of such proteins have been found to be evolutionary related [ , , ]. These proteins seem to contain up to 12 transmembrane segments. The best conserved region in this family is located in the second tran... | [
"GO:0006865",
"GO:0016020"
] | [
"amino acid transport",
"membrane"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"NCBIFAM"
] | [
"TIGR00907"
] | [
"2A0304"
] | [
884
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00001779",
"PUB00003402",
"PUB00005006"
] | [
"2687114",
"3146645",
"8382989"
] | [
"Nucleotide sequence of the Saccharomyces cerevisiae PUT4 proline-permease-encoding gene: similarities between CAN1, HIP1 and PUT4 permeases.",
"Evolutionary relationship and secondary structure predictions in four transport proteins of Saccharomyces cerevisiae.",
"Mammalian integral membrane receptors are homo... | [
1989,
1988,
1993
] | 3 | [
"IPR002293"
] | [] | 1 | 0 | 1 | [
"Eukaryota"
] | [
884
] | 1 | [
"Arabidopsis thaliana",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",
"Zea mays"
] | [
6,
1,
2,
1,
1,
3
] | 6 | true | Family | Amino acid permease subfamily | Amino acid permease subfamily | AA_permease | 2 |
IPR004757 | 4,757 | Ethanolamine permease | EtNH_permease | Family | 4,355 | false | false | Amino acid permeases are integral membrane proteins involved in the transport of amino acids into the cell. A number of such proteins have been found to be evolutionary related [ , , ]. These proteins seem to contain up to 12 transmembrane segments. The best conserved region in this family is located in the second tran... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"TIGR00908"
] | [
"2A0305"
] | [
4355
] | 1 | [
"GP",
"GP"
] | [
"GenProp0292",
"GenProp0294"
] | [
"GP:GenProp0292",
"GP:GenProp0294"
] | 2 | [] | 0 | [
"PUB00001779",
"PUB00003402",
"PUB00005006"
] | [
"2687114",
"3146645",
"8382989"
] | [
"Nucleotide sequence of the Saccharomyces cerevisiae PUT4 proline-permease-encoding gene: similarities between CAN1, HIP1 and PUT4 permeases.",
"Evolutionary relationship and secondary structure predictions in four transport proteins of Saccharomyces cerevisiae.",
"Mammalian integral membrane receptors are homo... | [
1989,
1988,
1993
] | 3 | [
"IPR002293"
] | [] | 1 | 0 | 1 | [
"Acyrthosiphon pisum",
"Bacteria",
"ecological metagenomes"
] | [
1,
4340,
14
] | 3 | [] | [] | 0 | true | Family | Ethanolamine permease | Ethanolamine permease | EtNH_permease | 1 |
IPR004758 | 4,758 | Amino acid transporter | AA_transporter | Family | 653 | false | false | Amino acid permeases are integral membrane proteins involved in the transport of amino acids into the cell. A number of such proteins have been found to be evolutionary related [ , , ]. These proteins seem to contain up to 12 transmembrane segments. The best conserved region in this family is located in the second tran... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"TIGR00909"
] | [
"2A0306"
] | [
653
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00001779",
"PUB00003402",
"PUB00005006",
"PUB00101915",
"PUB00101916"
] | [
"2687114",
"3146645",
"8382989",
"32743959",
"25645558"
] | [
"Nucleotide sequence of the Saccharomyces cerevisiae PUT4 proline-permease-encoding gene: similarities between CAN1, HIP1 and PUT4 permeases.",
"Evolutionary relationship and secondary structure predictions in four transport proteins of Saccharomyces cerevisiae.",
"Mammalian integral membrane receptors are homo... | [
1989,
1988,
1993,
2020,
2015
] | 5 | [
"IPR002293"
] | [] | 1 | 0 | 1 | [
"Archaeoglobus fulgidus",
"Bacteria"
] | [
2,
651
] | 2 | [] | [] | 0 | true | Family | Amino acid transporter | Amino acid transporter | AA_transporter | 3 |
IPR004760 | 4,760 | L-type amino acid transporter | L_AA_transporter | Family | 1,691 | false | false | null | [
"GO:0006865",
"GO:0016020"
] | [
"amino acid transport",
"membrane"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"NCBIFAM"
] | [
"TIGR00911"
] | [
"2A0308"
] | [
1691
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-210991",
"R-HSA-352230",
"R-HSA-71240",
"R-HSA-9818027",
"R-MMU-210991",
"R-MMU-352230",
"R-MMU-71240",
"R-RNO-210991",
"R-RNO-352230",
"R-RNO-71240"
] | [
"REACTOME:R-HSA-210991",
"REACTOME:R-HSA-352230",
"REACTOME:R-HSA-71240",
"REACTOME:R-HSA-9818027",
"REACTOME:R-MMU-210991",
"REACTOME:R-MMU-352230",
"REACTOME:R-MMU-71240",
"REACTOME:R-RNO-210991",
"REACTOME:R-RNO-352230",
"REACTOME:R-RNO-71240"
] | 10 | [
"6irs",
"6irt",
"6jmq",
"7b00",
"7ccs",
"7cmh",
"7cmi",
"7dsk",
"7dsl",
"7dsn",
"7dsq",
"7epz",
"7p9u",
"7p9v",
"8a6l",
"8ida",
"8j8l",
"8j8m",
"8kdd",
"8kdf",
"8kdg",
"8kdh",
"8kdi",
"8kdj",
"8kdn",
"8kdo",
"8kdp",
"8x0w",
"8xpu"
] | 29 | [
"PUB00001779",
"PUB00003402",
"PUB00005006"
] | [
"2687114",
"3146645",
"8382989"
] | [
"Nucleotide sequence of the Saccharomyces cerevisiae PUT4 proline-permease-encoding gene: similarities between CAN1, HIP1 and PUT4 permeases.",
"Evolutionary relationship and secondary structure predictions in four transport proteins of Saccharomyces cerevisiae.",
"Mammalian integral membrane receptors are homo... | [
1989,
1988,
1993
] | 3 | [
"IPR002293"
] | [] | 1 | 0 | 1 | [
"Bilateria"
] | [
1691
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
7,
8,
7
] | 4 | true | Family | L-type amino acid transporter | L-type amino acid transporter | L_AA_transporter | 2 |
IPR004761 | 4,761 | Spore germination GerAB | Spore_GerAB | Family | 14,292 | false | false | Amino acid permeases are integral membrane proteins involved in the transport of amino acids into the cell. A number of such proteins have been found to be evolutionary related [ , , ]. These proteins seem to contain up to 12 transmembrane segments. The best conserved region in this family is located in the second tran... | [
"GO:0009847",
"GO:0016020"
] | [
"spore germination",
"membrane"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PFAM",
"PANTHER",
"NCBIFAM"
] | [
"PF03845",
"PTHR34975",
"TIGR00912"
] | [
"Spore_permease",
"",
"2A0309"
] | [
14278,
13711,
11559
] | 3 | [
"GP"
] | [
"GenProp0610"
] | [
"GP:GenProp0610"
] | 1 | [] | 0 | [
"PUB00001779",
"PUB00003402",
"PUB00005006"
] | [
"2687114",
"3146645",
"8382989"
] | [
"Nucleotide sequence of the Saccharomyces cerevisiae PUT4 proline-permease-encoding gene: similarities between CAN1, HIP1 and PUT4 permeases.",
"Evolutionary relationship and secondary structure predictions in four transport proteins of Saccharomyces cerevisiae.",
"Mammalian integral membrane receptors are homo... | [
1989,
1988,
1993
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
14253,
5,
34
] | 3 | [
"Arabidopsis thaliana"
] | [
1
] | 1 | true | Family | Spore germination GerAB | Spore germination GerAB | Spore_GerAB | 8 |
IPR004763 | 4,763 | Cation efflux system CusA-like | CusA-like | Family | 21,253 | false | false | This family consists of the H+/heavy metal cation antiporters. CzcA has a low cation transport activity for cobalt and is essential for the expression of cobalt, zinc and cadmium resistance. CusA is a part of a cation efflux system that mediates resistance to copper and silver [ , ]. | [
"GO:0008324",
"GO:0006812",
"GO:0016020"
] | [
"monoatomic cation transmembrane transporter activity",
"monoatomic cation transport",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"NCBIFAM"
] | [
"TIGR00914"
] | [
"2A0601"
] | [
21253
] | 1 | [
"GP"
] | [
"GenProp1168"
] | [
"GP:GenProp1168"
] | 1 | [
"3k07",
"3k0i",
"3kso",
"3kss",
"3ne5",
"3t51",
"3t53",
"3t56",
"4dnr",
"4dnt",
"4dop",
"4k0e",
"4k0j",
"7kf5",
"7kf6",
"7kf7",
"7kf8"
] | 17 | [
"PUB00060427",
"PUB00060428"
] | [
"11399769",
"12813074"
] | [
"The independent cue and cus systems confer copper tolerance during aerobic and anaerobic growth in Escherichia coli.",
"Molecular analysis of the copper-transporting efflux system CusCFBA of Escherichia coli."
] | [
2001,
2003
] | 2 | [
"IPR001036"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Eukaryota",
"Siphoviridae sp. ctBLh2",
"unclassified sequences"
] | [
20946,
29,
1,
277
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Cation efflux system CusA-like | Cation efflux system CusA-like | CusA-like | 6 |
IPR004764 | 4,764 | Multidrug resistance protein MdtF-like | MdtF-like | Family | 33,359 | false | false | This entry represents a group of resistance-nodulation-cell division (RND) from bacteria, including Multidrug resistance protein MdtF from Escherichia coli. MdtF id part of the tripartite efflux system MdtEF-TolC, which confers resistance to compounds such as rhodamine 6G, erythromycin, doxorubicin, ethidium bromide, T... | [
"GO:0015562",
"GO:0042908",
"GO:0016020"
] | [
"efflux transmembrane transporter activity",
"xenobiotic transport",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"NCBIFAM"
] | [
"TIGR00915"
] | [
"2A0602"
] | [
33359
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-9638334",
"R-HSA-9760173",
"R-HSA-9913143"
] | [
"REACTOME:R-HSA-9638334",
"REACTOME:R-HSA-9760173",
"REACTOME:R-HSA-9913143"
] | 3 | [
"1iwg",
"1oy6",
"1oy8",
"1oy9",
"1oyd",
"1oye",
"1t9t",
"1t9u",
"1t9v",
"1t9w",
"1t9x",
"1t9y",
"2dhh",
"2dr6",
"2drd",
"2gif",
"2hqc",
"2hqd",
"2hqf",
"2hqg",
"2hrt",
"2i6w",
"2j8s",
"2rdd",
"2v50",
"2w1b",
"3aoa",
"3aob",
"3aoc",
"3aod",
"3d9b",
"3noc"... | 166 | [
"PUB00053912"
] | [
"11566977"
] | [
"Analysis of a complete library of putative drug transporter genes in Escherichia coli."
] | [
2001
] | 1 | [
"IPR001036"
] | [
"IPR061504"
] | 1 | 1 | 0 | [
"Bacteria",
"Eukaryota",
"Plasmid pMCBF1",
"unclassified sequences"
] | [
33228,
26,
1,
104
] | 4 | [
"Escherichia coli (strain K12)"
] | [
4
] | 1 | true | Family | Multidrug resistance protein MdtF-like | Multidrug resistance protein MdtF-like | MdtF-like | 9 |
IPR004765 | 4,765 | NPC1-like | NPC1-like | Family | 4,456 | false | false | This family includes mammalian Niemann-Pick C1 (NPC1) protein and its homologues from plants and yeasts. Human NPC1 is a endosomal/lysosomal membrane protein that facilitates the trafficking of cholesterol and other cargo from lysosomes, and is involved in cholesterol homeostasis. Mutations in the NPC1 gene cause the r... | [
"GO:0005319",
"GO:0016020"
] | [
"lipid transporter activity",
"membrane"
] | [
"molecular_function",
"cellular_component"
] | 2 | [
"NCBIFAM"
] | [
"TIGR00917"
] | [
"2A060601"
] | [
4456
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-8964038",
"R-MMU-8963678",
"R-MMU-8964038",
"R-RNO-8963678"
] | [
"REACTOME:R-HSA-8964038",
"REACTOME:R-MMU-8963678",
"REACTOME:R-MMU-8964038",
"REACTOME:R-RNO-8963678"
] | 4 | [
"3jd8",
"5jnx",
"5u73",
"5u74",
"6uox",
"6v3f",
"6v3h",
"6w5r",
"6w5s",
"6w5t",
"6w5u",
"6w5v",
"7df8",
"7dfw",
"7dfz",
"7n4u",
"7n4v",
"7n4x"
] | 18 | [
"PUB00077151"
] | [
"20007703"
] | [
"Niemann-Pick C1 functions independently of Niemann-Pick C2 in the initial stage of retrograde transport of membrane-impermeable lysosomal cargo."
] | [
2010
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4456
] | 1 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus",
"Zea mays"
] | [
11,
8,
4,
8,
6,
6,
3
] | 7 | true | Family | NPC1-like | NPC1-like | NPC1-like | 5 |
IPR004766 | 4,766 | Transmembrane receptor, patched | TM_rcpt_patched | Family | 3,116 | false | false | Patched (Ptc) is a Drosophila melanogaster (Fruit fly) membrane protein that plays a critical role in patterning embryonic and imaginal tissues. It constitutively inactivates the transcription of genes wingless, decapentaplegic, and patched itself. The secreted protein, hedgehog (Hh) induces transcription of genes by o... | [
"GO:0008158",
"GO:0016020"
] | [
"hedgehog receptor activity",
"membrane"
] | [
"molecular_function",
"cellular_component"
] | 2 | [
"NCBIFAM"
] | [
"TIGR00918"
] | [
"2A060602"
] | [
3116
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DME-209338",
"R-DME-5610787",
"R-DME-5632681",
"R-DME-5632684",
"R-HSA-373080",
"R-HSA-5610787",
"R-HSA-5632681",
"R-HSA-5632684",
"R-HSA-5635838",
"R-MMU-5610787",
"R-MMU-5632681",
"R-MMU-5632684",
"R-MMU-5635838"
] | [
"REACTOME:R-DME-209338",
"REACTOME:R-DME-5610787",
"REACTOME:R-DME-5632681",
"REACTOME:R-DME-5632684",
"REACTOME:R-HSA-373080",
"REACTOME:R-HSA-5610787",
"REACTOME:R-HSA-5632681",
"REACTOME:R-HSA-5632684",
"REACTOME:R-HSA-5635838",
"REACTOME:R-MMU-5610787",
"REACTOME:R-MMU-5632681",
"REACTOME:... | 13 | [
"6dmb",
"6dmo",
"6dmy",
"6e1h",
"6mg8",
"6n7g",
"6n7h",
"6n7k",
"6oeu",
"6oev",
"6rmg",
"6rvd",
"7k65",
"7rhq",
"7rhr",
"7v6y",
"7v6z",
"9ms8"
] | 18 | [
"PUB00035901",
"PUB00035902",
"PUB00035903"
] | [
"8575316",
"12192414",
"17284519"
] | [
"patched overexpression alters wing disc size and pattern: transcriptional and post-transcriptional effects on hedgehog targets.",
"Patched acts catalytically to suppress the activity of Smoothened.",
"A large complex containing Patched and Smoothened initiates Hedgehog signaling in Drosophila."
] | [
1995,
2002,
2007
] | 3 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
3116
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
1,
5,
4,
7
] | 5 | true | Family | Transmembrane receptor, patched | Transmembrane receptor, patched | TM_rcpt_patched | 4 |
IPR004768 | 4,768 | Oligopeptide transporter | Oligopep_transport | Family | 978 | false | false | This entry represents a subfamily of OPT proteins that are involved in oligopeptide transport. Their transport activity is proton dependent [ ]. These proteins may constitute a major route for the absorption of the end products of protein digestion [ ]. | [
"GO:0035673",
"GO:0006857",
"GO:0016020"
] | [
"oligopeptide transmembrane transporter activity",
"oligopeptide transport",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"NCBIFAM"
] | [
"TIGR00926"
] | [
"2A1704"
] | [
978
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-427975",
"R-DME-427975",
"R-HSA-427975",
"R-MMU-427975",
"R-RNO-427975"
] | [
"REACTOME:R-CEL-427975",
"REACTOME:R-DME-427975",
"REACTOME:R-HSA-427975",
"REACTOME:R-MMU-427975",
"REACTOME:R-RNO-427975"
] | 5 | [
"7nqk",
"7pmw",
"7pmx",
"7pmy",
"7pn1",
"7s8u",
"9bir",
"9bis",
"9bit",
"9biu"
] | 10 | [
"PUB00060980"
] | [
"9730971"
] | [
"The opt1 gene of Drosophila melanogaster encodes a proton-dependent dipeptide transporter."
] | [
1998
] | 1 | [
"IPR000109"
] | [] | 1 | 0 | 1 | [
"Bilateria"
] | [
978
] | 1 | [
"Caenorhabditis elegans",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
2,
7,
6,
8
] | 5 | true | Family | Oligopeptide transporter | Oligopeptide transporter | Oligopep_transport | 7 |
IPR004769 | 4,769 | Adenylosuccinate lyase | Pur_lyase | Family | 29,250 | false | false | This family consists of adenylosuccinate lyase, the enzyme that catalyses step 8 in the purine biosynthesis pathway for de novo synthesis of IMP, and also the final reaction in the two-step sequence from IMP to AMP [ , ]. It is a member of lyase class I family, which functions as homotetramers. The four active sites of... | [
"GO:0004018",
"GO:0009152"
] | [
"N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity",
"purine ribonucleotide biosynthetic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"NCBIFAM"
] | [
"TIGR00928"
] | [
"purB"
] | [
29250
] | 1 | [
"EC",
"GP",
"GP",
"GP",
"GP",
"GP",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"4.3.2.2",
"GenProp0110",
"GenProp0747",
"GenProp1372",
"GenProp1730",
"GenProp1757",
"PWY-6123",
"PWY-6124",
"PWY-7219",
"PWY-7234",
"PWY-8289",
"R-GGA-419140",
"R-GGA-421203",
"R-HSA-73817",
"R-MMU-73817",
"R-SCE-73817",
"R-SPO-73817"
] | [
"EC:4.3.2.2",
"GP:GenProp0110",
"GP:GenProp0747",
"GP:GenProp1372",
"GP:GenProp1730",
"GP:GenProp1757",
"METACYC:PWY-6123",
"METACYC:PWY-6124",
"METACYC:PWY-7219",
"METACYC:PWY-7234",
"METACYC:PWY-8289",
"REACTOME:R-GGA-419140",
"REACTOME:R-GGA-421203",
"REACTOME:R-HSA-73817",
"REACTOME:... | 17 | [
"1c3c",
"1c3u",
"1dof",
"1f1o",
"2hvg",
"2j91",
"2pfm",
"2ptq",
"2ptr",
"2pts",
"2qga",
"2vd6",
"2x75",
"3bhg",
"3gzh",
"4eei",
"4efc",
"4ffx",
"4flc",
"4mx2",
"4nle",
"4nsl",
"5e3v",
"5eyt",
"5eyv",
"5hw2",
"5nx8",
"5nx9",
"5nxa",
"5v4l",
"5vkw",
"7t24"... | 35 | [
"PUB00017611",
"PUB00023841",
"PUB00151518"
] | [
"1729205",
"10673438",
"36309089"
] | [
"Escherichia coli purB gene: cloning, nucleotide sequence, and regulation by purR.",
"The structure of adenylosuccinate lyase, an enzyme with dual activity in the de novo purine biosynthetic pathway.",
"Identification of a S-(2-succino)cysteine breakdown pathway that uses a novel S-(2-succino) lyase."
] | [
1992,
2000,
2022
] | 3 | [
"IPR000362"
] | [
"IPR047136"
] | 1 | 1 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
674,
23595,
4536,
3,
442
] | 5 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae... | [
10,
1,
2,
1,
15,
4,
1,
3,
4,
1,
1,
7
] | 12 | true | Family | Adenylosuccinate lyase | Adenylosuccinate lyase | Pur_lyase | 1 |
IPR004770 | 4,770 | Na+/H+ antiporter NhaC | Na/H_antiport_NhaC | Family | 7,876 | false | false | Members of the NhaC family of antiporters are found in bacteria and Archaea. The family member from Bacillus firmus has been functionally characterised and is involved in pH homeostasis and sodium extrusion [ ]. In Bacillus subtilis, this antiporter influence bacterial growth, alkaline phosphatase synthesis, and its ow... | [
"GO:0015297",
"GO:0016020"
] | [
"antiporter activity",
"membrane"
] | [
"molecular_function",
"cellular_component"
] | 2 | [
"NCBIFAM"
] | [
"TIGR00931"
] | [
"antiport_nhaC"
] | [
7876
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00019907",
"PUB00057359",
"PUB00094157"
] | [
"9190799",
"18930051",
"11274110"
] | [
"Role of the nhaC-encoded Na+/H+ antiporter of alkaliphilic Bacillus firmus OF4.",
"Identification of the arginine/ornithine antiporter ArcD from Halobacterium salinarum.",
"Bacillus subtilis NhaC, an Na+/H+ antiporter, influences expression of the phoPR operon and production of alkaline phosphatases."
] | [
1997,
2008,
2001
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Methanobacteriota",
"Protostomia",
"metagenomes"
] | [
7643,
194,
4,
35
] | 4 | [] | [] | 0 | true | Family | Na+/H+ antiporter NhaC | Na+/H+ antiporter NhaC | Na/H_antiport_NhaC | 9 |
IPR004771 | 4,771 | K+/H+ exchanger | K/H_exchanger | Domain | 14,292 | false | false | The monovalent Cation:Proton antiporter-2 (CPA2) family acts as a K+/H+ exchangers that facilitate potassium-efflux, possibly by potassium-proton antiport. This family includes KefB and KefC transporters, which are part of a glutathione-gated K(+) efflux system in Escherichia coli [ ]. The activity of the KefB and KefC... | [
"GO:0008324",
"GO:0006812",
"GO:0016020"
] | [
"monoatomic cation transmembrane transporter activity",
"monoatomic cation transport",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"NCBIFAM"
] | [
"TIGR00932"
] | [
"2a37"
] | [
14292
] | 1 | [] | [] | [] | 0 | [
"8bxg",
"8by2",
"9emb"
] | 3 | [
"PUB00044836",
"PUB00044837"
] | [
"17679694",
"10632882"
] | [
"Three two-component transporters with channel-like properties have monovalent cation/proton antiport activity.",
"Protection of the DNA during the exposure of Escherichia coli cells to a toxic metabolite: the role of the KefB and KefC potassium channels."
] | [
2007,
2000
] | 2 | [
"IPR006153"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Eukaryota",
"Methanosarcinaceae",
"metagenomes"
] | [
13343,
904,
4,
41
] | 4 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)",
"Oryza sativa subsp. japonica",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Zea mays"
] | [
9,
3,
4,
1,
41
] | 5 | true | Domain | K+/H+ exchanger | K+/H+ exchanger | K/H_exchanger | 2 |
IPR004772 | 4,772 | TrkH potassium transport family | TrkH | Family | 17,010 | false | false | The Trk system is a low to medium affinity potassium uptake system, widely found in both in bacteria and archaea, where the uptake of K(+) is believed to be linked to H(+) symport [ ]. The core Trk system consists of two proteins, the integral membrane K(+)-translocating protein TrkH (or TrkG), and the regulatory NAD-b... | [
"GO:0015379",
"GO:0071805",
"GO:0016020"
] | [
"potassium:chloride symporter activity",
"potassium ion transmembrane transport",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PIRSF",
"NCBIFAM"
] | [
"PIRSF006247",
"TIGR00933"
] | [
"TrkH",
"2a38"
] | [
12058,
9314
] | 2 | [] | [] | [] | 0 | [
"3pjz",
"4j7c",
"4j9u",
"5but",
"6v4j",
"6v4k",
"6v4l",
"7zp9",
"7zpo",
"7zpr",
"8k1s",
"8k1t",
"8k1u",
"8poo",
"8xmh",
"8xmi"
] | 16 | [
"PUB00005718",
"PUB00042655",
"PUB00042656",
"PUB00042657",
"PUB00061657",
"PUB00099198",
"PUB00099201"
] | [
"8157629",
"10423425",
"15205426",
"9720051",
"22316140",
"31992706",
"27803167"
] | [
"Sequencing and characterization of the ntp gene cluster for vacuolar-type Na(+)-translocating ATPase of Enterococcus hirae.",
"Evolutionary relationship between K(+) channels and symporters.",
"Multiple paths for nonphysiological transport of K+ in Escherichia coli.",
"Cloning of the trkAH gene cluster and c... | [
1994,
1999,
2004,
1998,
2012,
2020,
2016
] | 7 | [
"IPR003445"
] | [] | 1 | 0 | 1 | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
811,
15977,
7,
215
] | 4 | [
"Escherichia coli (strain K12)"
] | [
2
] | 1 | true | Family | TrkH potassium transport family | TrkH potassium transport family | TrkH | 6 |
IPR004773 | 4,773 | Potassium/sodium transporter Trk1/HKT1 | K/Na_transp_Trk1/HKT1 | Family | 2,698 | false | false | Trk1 (also known as Trk) transporters play a crucial roles in K(+) transport in yeasts and filamentous fungi [ , , ]. A related transporter from plants is known as HKT1 (also known as HKT). It was identified in barley as a high-affinity potassium transporter [ ]. In Arabidopsis, HKT1 functions as a salt tolerance deter... | [
"GO:0015079",
"GO:0071805",
"GO:0016020"
] | [
"potassium ion transmembrane transporter activity",
"potassium ion transmembrane transport",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"NCBIFAM"
] | [
"TIGR00934"
] | [
"2a38euk"
] | [
2698
] | 1 | [] | [] | [] | 0 | [
"8w9n",
"8w9o"
] | 2 | [
"PUB00073533",
"PUB00073535",
"PUB00073540",
"PUB00073541",
"PUB00153147"
] | [
"11698666",
"9437867",
"24021239",
"17626012",
"15485849"
] | [
"AtHKT1 is a salt tolerance determinant that controls Na(+) entry into plant roots.",
"The HAK1 gene of barley is a member of a large gene family and encodes a high-affinity potassium transporter.",
"Role of Saccharomyces cerevisiae Trk1 in stabilization of intracellular potassium content upon changes in extern... | [
2001,
1997,
2014,
2007,
2004
] | 5 | [
"IPR003445"
] | [
"IPR015958"
] | 1 | 1 | 0 | [
"Eukaryota"
] | [
2698
] | 1 | [
"Arabidopsis thaliana",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
6,
1,
2,
2
] | 4 | true | Family | Potassium/sodium transporter Trk1/HKT1 | Potassium/sodium transporter Trk1/HKT1 | K/Na_transp_Trk1/HKT1 | 4 |
IPR004775 | 4,775 | Na(+)/H(+) antiporter subunit D1 | MnhD1 | Family | 78 | false | false | This entry represents the Na(+)/H(+) antiporter subunit D1. It forms a complex (consists of seven subunits:MrpA, MrpB, MrpC, MrpD, MrpE, MrpF and MrpG) that is involved in Na+ and/or Li+ excretion [ ]. Na+/H+ antiport consumes a transmembrane electrical potential, and is thus inferred to be electrogenic [ , ]. It share... | [
"GO:0015386",
"GO:0006812",
"GO:0016020"
] | [
"potassium:proton antiporter activity",
"monoatomic cation transport",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"NCBIFAM"
] | [
"TIGR00944"
] | [
"2a6301s04"
] | [
78
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00009818",
"PUB00057356",
"PUB00067873"
] | [
"10198001",
"17293423",
"17693497"
] | [
"mrp, a multigene, multifunctional locus in Bacillus subtilis with roles in resistance to cholate and to Na+ and in pH homeostasis.",
"Catalytic properties of Staphylococcus aureus and Bacillus members of the secondary cation/proton antiporter-3 (Mrp) family are revealed by an optimized assay in an Escherichia co... | [
1999,
2007,
2007
] | 3 | [
"IPR003918"
] | [] | 1 | 0 | 1 | [
"Bacteria"
] | [
78
] | 1 | [] | [] | 0 | true | Family | Na(+)/H(+) antiporter subunit D1 | Na(+)/H(+) antiporter subunit D1 | MnhD1 | 7 |
IPR004776 | 4,776 | Membrane transport PIN-like | Mem_transp_PIN-like | Family | 51,370 | false | false | This entry represents a family of membrane transport proteins found in eukaryotes, bacteria and archaea. Most characterised members of this family are the PIN components of auxin efflux systems from plants [ ]. These carriers are saturable, auxin-specific, and localized to the basal ends of auxin transport-competent ce... | [
"GO:0055085",
"GO:0016020"
] | [
"transmembrane transport",
"membrane"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PFAM"
] | [
"PF03547"
] | [
"Mem_trans"
] | [
51370
] | 1 | [] | [] | [] | 0 | [
"7qp9",
"7qpa",
"7qpc",
"7wks",
"7wkw",
"7xxb",
"7y9t",
"7y9u",
"7y9v",
"8jh5",
"8u54",
"8u56",
"8u58",
"8u5c",
"8u5n",
"8u5q",
"8u5v",
"8u5x",
"8wr3",
"8y56",
"8z8z",
"9g0w",
"9g0x",
"9g0z",
"9g10",
"9j3x",
"9j3z",
"9j40",
"9jbe",
"9jbf",
"9jbg",
"9jbh"... | 34 | [
"PUB00033872",
"PUB00033873",
"PUB00151519",
"PUB00151524"
] | [
"16054428",
"15564124",
"35768502",
"36007018"
] | [
"Auxin transport.",
"PIN and AUX/LAX proteins: their role in auxin accumulation.",
"Structures and mechanism of the plant PIN-FORMED auxin transporter.",
"Lysosomal GPCR-like protein LYCHOS signals cholesterol sufficiency to mTORC1."
] | [
2005,
2004,
2022,
2022
] | 4 | [] | [
"IPR014024",
"IPR039305",
"IPR040254",
"IPR045033"
] | 0 | 4 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
666,
31234,
19181,
2,
287
] | 5 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae... | [
71,
9,
2,
1,
2,
2,
2,
46,
6,
4,
1,
83
] | 12 | true | Family | Membrane transport PIN-like | Membrane transport PIN-like | Mem_transp_PIN-like | 2 |
IPR004777 | 4,777 | L-lysine exporter/arginine exporter | Lys/arg_exporter | Family | 1,416 | false | false | L-lysine exporter, LysE is an exporter, which: (i) structurally represents a new type of translocator; (ii) demonstrates that exporters are also present for primary metabolites such as amino acids; and (iii) serves in one physiological function to link import with export activity [ ]. The arginine exporter protein ArgO... | [
"GO:0016020"
] | [
"membrane"
] | [
"cellular_component"
] | 1 | [
"NCBIFAM"
] | [
"TIGR00948"
] | [
"2a75"
] | [
1416
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00003877",
"PUB00042858"
] | [
"8971704",
"15150242"
] | [
"A new type of transporter with a new type of cellular function: L-lysine export from Corynebacterium glutamicum.",
"Evidence for an arginine exporter encoded by yggA (argO) that is regulated by the LysR-type transcriptional regulator ArgP in Escherichia coli."
] | [
1996,
2004
] | 2 | [
"IPR001123"
] | [
"IPR023445"
] | 1 | 1 | 0 | [
"Bacteria",
"human gut metagenome"
] | [
1415,
1
] | 2 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | L-lysine exporter/arginine exporter | L-lysine exporter/arginine exporter | Lys/arg_exporter | 9 |
IPR004778 | 4,778 | Homoserine/Threonine efflux protein | Homoserine/Threonine_efflux | Family | 2,751 | false | false | Proteins in this group include: A chemotactic transduction protein from Pseudomonas aeruginosa. The homoserine/homoserine lactone efflux protein from Escherichia coli. and a number of hypothetical proteins. | [
"GO:0016020"
] | [
"membrane"
] | [
"cellular_component"
] | 1 | [
"NCBIFAM"
] | [
"TIGR00949"
] | [
"2A76"
] | [
2751
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [
"IPR001123"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Rhizophagus irregularis"
] | [
2750,
1
] | 2 | [
"Escherichia coli (strain K12)"
] | [
3
] | 1 | true | Family | Homoserine/Threonine efflux protein | Homoserine/Threonine efflux protein | Homoserine/Threonine_efflux | 2 |
IPR004783 | 4,783 | Galactose-6-phosphate isomerase subunit LacA | LacA | Family | 638 | false | false | Galactose-6-phosphate isomerase ( ) is a heteromultimeric protein consisting of subunits LacA and LacB, and catalyses the conversion of D-galactose 6-phosphate to D-tagatose and 6-phosphate in the tagatose 6-phosphate pathway of lactose catabolism [ ]. Galactose-6-phosphate isomerase is induced by galactose or lactose.... | [
"GO:0050044",
"GO:0005990"
] | [
"galactose-6-phosphate isomerase activity",
"lactose catabolic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"HAMAP",
"NCBIFAM"
] | [
"MF_01555",
"TIGR01118"
] | [
"LacA",
"lacA"
] | [
533,
637
] | 2 | [
"EC",
"GP"
] | [
"5.3.1.26",
"GenProp0141"
] | [
"EC:5.3.1.26",
"GP:GenProp0141"
] | 2 | [] | 0 | [
"PUB00002200"
] | [
"1400164"
] | [
"Nucleotide and deduced amino acid sequences of the lacR, lacABCD, and lacFE genes encoding the repressor, tagatose 6-phosphate gene cluster, and sugar-specific phosphotransferase system components of the lactose operon of Streptococcus mutans."
] | [
1992
] | 1 | [
"IPR003500"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"metagenomes"
] | [
636,
2
] | 2 | [] | [] | 0 | true | Family | Galactose-6-phosphate isomerase subunit LacA | Galactose-6-phosphate isomerase subunit LacA | LacA | 4 |
IPR004784 | 4,784 | Galactose-6-phosphate isomerase subunit LacB | LacB | Family | 597 | false | false | Galactose-6-phosphate isomerase ( ) is a heteromultimeric protein consisting of subunits LacA and LacB, and catalyses the conversion of D-galactose 6-phosphate to D-tagatose and 6-phosphate in the tagatose 6-phosphate pathway of lactose catabolism [ ]. Galactose-6-phosphate isomerase is induced by galactose or lactose.... | [
"GO:0016861",
"GO:0050044",
"GO:0005990"
] | [
"intramolecular oxidoreductase activity, interconverting aldoses and ketoses",
"galactose-6-phosphate isomerase activity",
"lactose catabolic process"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"HAMAP",
"NCBIFAM"
] | [
"MF_01556",
"TIGR01119"
] | [
"LacB",
"lacB"
] | [
595,
549
] | 2 | [
"EC",
"GP"
] | [
"5.3.1.26",
"GenProp0141"
] | [
"EC:5.3.1.26",
"GP:GenProp0141"
] | 2 | [] | 0 | [
"PUB00002200"
] | [
"1400164"
] | [
"Nucleotide and deduced amino acid sequences of the lacR, lacABCD, and lacFE genes encoding the repressor, tagatose 6-phosphate gene cluster, and sugar-specific phosphotransferase system components of the lactose operon of Streptococcus mutans."
] | [
1992
] | 1 | [
"IPR003500"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"human gut metagenome"
] | [
596,
1
] | 2 | [] | [] | 0 | true | Family | Galactose-6-phosphate isomerase subunit LacB | Galactose-6-phosphate isomerase subunit LacB | LacB | 1 |
IPR004785 | 4,785 | Ribose 5-phosphate isomerase B | RpiB | Family | 10,587 | false | false | Ribose 5-phosphate isomerase ( ) forms a homodimer and catalyses the interconversion of D-ribose 5-phosphate and D-ribulose 5-phosphate in the non-oxidative branch of the pentose phosphate pathway. This reaction permits the synthesis of ribose from other sugars, as well as the recycling of sugars from nucleotide breakd... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"TIGR01120"
] | [
"rpiB"
] | [
10587
] | 1 | [
"EC",
"GP",
"GP",
"GP",
"GP"
] | [
"5.3.1",
"GenProp0120",
"GenProp1294",
"GenProp1438",
"GenProp1463"
] | [
"EC:5.3.1",
"GP:GenProp0120",
"GP:GenProp1294",
"GP:GenProp1438",
"GP:GenProp1463"
] | 5 | [
"1nn4",
"1o1x",
"2vvr",
"3he8",
"3hee",
"3k7o",
"3k7p",
"3k7s",
"3k8c",
"3m1p",
"3ph3",
"3ph4",
"3s5p",
"4em8",
"6fxl",
"6fxs",
"6fxw",
"6mu0"
] | 18 | [
"PUB00029142",
"PUB00091681"
] | [
"14499611",
"29867142"
] | [
"The 2.2 A resolution structure of RpiB/AlsB from Escherichia coli illustrates a new approach to the ribose-5-phosphate isomerase reaction.",
"Functional assignment of multiple catabolic pathways for D-apiose."
] | [
2003,
2018
] | 2 | [
"IPR003500"
] | [] | 1 | 0 | 1 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
9,
10186,
143,
2,
247
] | 5 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Ribose 5-phosphate isomerase B | Ribose 5-phosphate isomerase B | RpiB | 9 |
IPR004786 | 4,786 | 6-phosphogluconate dehydratase | 6-phosphgluc_deHydtase | Family | 8,207 | false | false | Two dehydratases, dihydroxy-acid dehydratase (gene ilvD or ILV3) and 6-phosphogluconate dehydratase (gene edd) have been shown to be evolutionary related [ ]. Dihydroxy-acid dehydratase catalyzes the fourth step in the biosynthesis of isoleucine and valine, the dehydration of 2,3-dihydroxy-isovaleic acid into alpha-ket... | [
"GO:0004456",
"GO:0009255"
] | [
"phosphogluconate dehydratase activity",
"Entner-Doudoroff pathway through 6-phosphogluconate"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"HAMAP",
"NCBIFAM"
] | [
"MF_02094",
"TIGR01196"
] | [
"Edd",
"edd"
] | [
7948,
8193
] | 2 | [
"EC",
"GP",
"GP",
"GP"
] | [
"4.2.1.12",
"GenProp0468",
"GenProp1557",
"GenProp1691"
] | [
"EC:4.2.1.12",
"GP:GenProp0468",
"GP:GenProp1557",
"GP:GenProp1691"
] | 4 | [
"2gp4"
] | 1 | [
"PUB00001841",
"PUB00002191",
"PUB00101687"
] | [
"8299945",
"1624451",
"17102132"
] | [
"Cloning of the dihydroxyacid dehydratase-encoding gene (ILV3) from Saccharomyces cerevisiae.",
"Molecular characterization of the Entner-Doudoroff pathway in Escherichia coli: sequence analysis and localization of promoters for the edd-eda operon.",
"Micromolar intracellular hydrogen peroxide disrupts metaboli... | [
1993,
1992,
2007
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Candidatus Nitrosopumilus salarius BD31",
"Eukaryota",
"unclassified sequences"
] | [
8160,
1,
7,
39
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | 6-phosphogluconate dehydratase | 6-phosphogluconate dehydratase | 6-phosphgluc_deHydtase | 2 |
IPR004787 | 4,787 | Competence protein ComEA | Competence_ComE | Family | 258 | false | false | Competence is the ability of a cell to take up exogenous DNA from its environment, resulting in transformation. It is widespread among bacteria and is probably an important mechanism for the horizontal transfer of genes. DNA usually becomes available by the death and lysis of other cells. Competent bacteria use compone... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"TIGR01259"
] | [
"comE"
] | [
258
] | 1 | [] | [] | [] | 0 | [
"8dfk"
] | 1 | [
"PUB00007027",
"PUB00052316",
"PUB00052317"
] | [
"7768800",
"8901420",
"10361283"
] | [
"ComEA, a Bacillus subtilis integral membrane protein required for genetic transformation, is needed for both DNA binding and transport.",
"Who's competent and when: regulation of natural genetic competence in bacteria.",
"Mutational analysis of ComS: evidence for the interaction of ComS and MecA in the regulat... | [
1995,
1996,
1999
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria"
] | [
258
] | 1 | [] | [] | 0 | true | Family | Competence protein ComEA | Competence protein ComEA | Competence_ComE | 9 |
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