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"global_id": "webtext-fineweb__CC-MAIN-2019-39__0__45318361", "lang": "en", "text": "We at RASA life science informatics in Pune conduct Computer Aided Drug Discovery Designing Training Course (CADD) or Pharmacoinformatics Training course in accordance to the recent trends in the industry. Our Computer Aided Drug Discovery Designing Training Course contains detailed knowledge about the different methods and techniques taught in a more practical manner. RASA’s training is highly ranked in India and till date, we have more than 1000 students.\nBy definition, computer aided drug discovery designing training course is a specialized discipline that uses computational methods to simulate drug-receptor interactions. CADD methods are heavily dependent on bioinformatics tools, application and on the support side of the hub, information technology, in- formation management, software applications, databases and computational resources all provide the infrastructure for bioinformatics and biotechnology. On the scientific side of the hub, bioinformatics methods are used extensively in molecular biology, genomics, proteomics, other emerging areas (i.e. metabolomics, transcriptomics) and in CADD re- search. There are several key areas where bioinformatics supports Computer Aided Drug Discovery Designing research.\nComputer Aided Drug Design is central to rational drug design and drug discovery process. It contributes to the selection and synthesis of new materials, and guides the design of catalysts. New quantum mechanical techniques underline the understanding of electronic properties of materials and have advanced the level of precision at which moderate size molecules can be modeled. Computer-aided drug design uses computational chemistry to discover, enhance, or study drugs and related biologically active molecules. The fundamental goal is to predict whether a given molecule will bind to a target and if so, then, how strongly.", "domain": "chemistry", "round": 3} +{"url": "http://trpv1inhibitor.com/2021/07/08/76/", "date": "2022-10-04T09:54:30Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-40/segments/1664030337490.6/warc/CC-MAIN-20221004085909-20221004115909-00717.warc.gz", "language_score": 0.9189253449440002, "token_count": 863, "dump": "CC-MAIN-2022-40", "global_id": "webtext-fineweb__CC-MAIN-2022-40__0__278998115", "lang": "en", "text": "Iple demonstration that Pol I repression and targeting of RPA194 is often a feasible anticancer method. In our initial research we showed that PTC-209 Epigenetics BMH-21 didn’t activate ATM-dependent pathways accountable for p53 activity, H2AX or KAP1 phosphorylation . This was intriguing noting the DNA intercalation house of BMH-21 and binding to GC-rich DNA [13, 14], properties which are shared by quite a few polyaromatic heterocyclic intercalators. When several result in DNA harm by electrophilic addition, increased reactive oxygen species production, interfacial inhibition of DNA cleaving enzymes, other people like chloroquine changeimpactjournals.com/oncotargetchromatin conformation and activate the ATM pathway [1, 21]. Right here we show that BMH-21 activity towards Pol I is independent of DNA damage signaling or repair pathways. We additional assessed regardless of whether chemical adjustments introduced to BMH-21 could activate DDR. We show that quite a few derivative molecules, with adjustments within the BMH-21 simple sidechain, had considerably decreased potencies to inhibit Pol I but triggered activation from the DDR response. These findings show that effective Pol I targeting by the tetracyclic DNA intercalator occurs independent from the DNA damaging activity associated with frequent intercalators.RESULTSBMH-21 regulation of RNA Pol I is independent of DNA harm signalingATM is sensitive to alterations in chromatin conformation and DNA harm including those provoked by DNA intercalators. We’ve earlier shown that BMH21 will not activate marks of DNA damage, H2AX or phosphorylation of KAP1, both targets of ATM . To further confirm whether BMH-21 impacts ATM activity, we assessed ATM phosphorylation on Ser-1891 (PATM). As controls we employed ionizing radiation (IR) to lead to ds DNA Sugar Inhibitors medchemexpress breaks, and employed ATM-specific inhibitor KU55933 to block ATM activity. As shown in Fig. 1A, BMH-21 did not bring about ATM phosphorylation. To ask irrespective of whether BMH-21 activity towards Pol I inhibition will depend on ATM kinase activity, we analyzed whether inhibition of ATM activity impacts BMH-21-mediated relocalization of nucleolin (NCL), a marker of nucleolar anxiety. NCL translocation by BMH-21 was prominent also inside the presence of abrogated ATM activity (Fig. 1B). Given that BMH-21 causes profound replicative arrest we viewed as that BMH21 activity could rely on ATR pathway, the important sensor of replicative strain . To assess this, we made use of a gene knock-in cell model exactly where the endogenous ATR gene has been introduced by mutation of A2101 to G causing ATR inactivation (DLD-Seckel cells, ref. ). BMH-21caused translocation of nucleophosmin (NPM) was intact in these cells (Fig. 1C). We have shown that degradation of RPA194, the Pol I catalytic subunit, is usually a special activity of BMH-21 . To further address whether other essential damage signaling and repair pathways could interfere with degradation of RPA194, we pretreated cells with inhibitors of ATM (KU55933), caffeine (ATM/ATR), PI3 kinases (wortmannin) and DNA-PKcs (NU7441), and analyzed the expression and localization of RPA194 and UBF, both markers of active Pol I transcription centers. BMH-21 triggered RPA194 degradation and nucleolar cap formation of UBF as we have described prior to , but none of the inhibitors affected these nucleolar responses (Fig. 1D).OncotargetWe additional confirmed by western blotting that RPA194 was degraded by BMH-21 in cells with blocked ATM and DNA-PKcs activity (Fig. 1E and F). Further, we asked whether DNA damage by IR and activation of DDR could attenuat.", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/odz3-antibody-ab82575.html", "date": "2019-12-12T05:48:01Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-51/segments/1575540537212.96/warc/CC-MAIN-20191212051311-20191212075311-00448.warc.gz", "language_score": 0.8144566416740417, "token_count": 743, "dump": "CC-MAIN-2019-51", "global_id": "webtext-fineweb__CC-MAIN-2019-51__0__143822740", "lang": "en", "text": "Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.\nStorage bufferpH: 7.30\nPreservative: 0.02% Sodium azide\nConstituents: 0.5% Tris buffered saline, 0.5% BSA\nConcentration information loading...\nPurityImmunogen affinity purified\nPurification notesab82575 is purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.\nOur Abpromise guarantee covers the use of ab82575 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\nIHC-P: Use at a concentration of 1.5 - 3 µg/ml.\nPeptide ELISA: Antibody detection limit dilution 1/16000.\nWB: Preliminary experiments in Human brain lysates and in lysates of cell line NIH 3T3 gave no specific signal but low background (at antibody concentration up to 1µg/ml).\nNot yet tested in other applications.\nOptimal dilutions/concentrations should be determined by the end user.\nFunctionInvolved in neural development, regulating the establishment of proper connectivity within the nervous system. Promotes axon guidance and homophilic cell adhesion. Plays a role in the development of the visual pathway; regulates the formation in ipsilateral retinal mapping to both the dorsal lateral geniculate nucleus (dLGN) and the superior colliculus (SC). May be involved in the differentiation of the fibroblast-like cells in the superficial layer of mandibular condylar cartilage into chondrocytes. May function as a cellular signal transducer.\nTissue specificityExpressed in adult and fetal brain, slightly lower levels in testis and ovary, and intermediate levels in all other peripheral tissues examined. Not expressed in spleen or liver. Expression was high in brain, with highest levels in amygdala and caudate nucleus, followed by thalamus and subthalamic nucleus.\nInvolvement in diseaseMicrophthalmia, isolated, with coloboma, 9\nSequence similaritiesBelongs to the tenascin family. Teneurin subfamily.\nContains 8 EGF-like domains.\nContains 5 NHL repeats.\nContains 1 teneurin N-terminal domain.\nContains 23 YD repeats.\nDomainEGF-like domains 2 and 5 which have an odd number of cysteines might enable the formation of intermolecular disulfide bonds.\nCytoplasmic proline-rich regions could serve as docking domains for intracellular SH3-containing proteins.\nCellular localizationMembrane. Cell projection, axon.\n- Information by UniProt\n- FLJ10474 antibody\n- FLJ10886 antibody\n- KIAA1455 antibody\nab82575 staining ODZ in human cerebellum tissue by Immunohistochemistry (Formalin/PFA fixed paraffin embedded sections). Primary antibody used at 1.5µg/ml.\nNote the nuclear staining of the granular cell layer.\nab82575 staining ODZ3 in HeLa cells by Immunocytochemistry/ Immunofluorescence. Primary antibody used at 10µg/ml.\nab82575 has not yet been referenced specifically in any publications.", "domain": "chemistry", "round": 3} +{"url": "https://dspace.stir.ac.uk/handle/1893/29384", "date": "2020-11-23T22:02:13Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-50/segments/1606141168074.3/warc/CC-MAIN-20201123211528-20201124001528-00476.warc.gz", "language_score": 0.9413385987281799, "token_count": 775, "dump": "CC-MAIN-2020-50", "global_id": "webtext-fineweb__CC-MAIN-2020-50__0__218541367", "lang": "en", "text": "|Appears in Collections:||eTheses from Faculty of Natural Sciences legacy departments|\n|Title:||Secretion of extracellular proteins by Aeromonas salmonicida and related species|\n|Author(s):||Wilson, Stuart E,|\n|Publisher:||University of Stirling|\n|Abstract:||This thesis describes the study of extracellular enzyme activities secreted by the Gram- negative bacterium Aeromonas salmonicida and related species. Initially, cell fractionation criteria were used to define operationally the cellular and extracellular location of proteins. It was demonstrated that proteins detectable in the extracellular medium of A. salmonicida were selectively secreted beyond the outer membrane and not present as a result of general non-specific release due to cell lysis. Several extracellular enzyme activities were detected in the culture filtrate of A. salmonicida, of which a number of protease and amylase activities were partially characterised. The principal extracellular protease of M, 70000 was purified to homogeneity by a combination of ion-exchange and gel filtration chromatography, while another major extracellular protein of M, 56000 was purified by preparative-SDS-polyacrylamide gel electrophoresis. Rabbit polyclonal antibodies were then raised against these purified extracellular proteins. In assays with trout erythrocytes, haemolytic activity in the culture filtrate was inhibited by pre incubating with antibodies raised against the 56kDa protein, suggesting that this protein is in fact a haemolysin. After the preliminary studies on the production of extracellular proteins by this organism, a series of experiments was carried out to compare the extracellular protein production of A. salmonicida and related species. The study of strain variation at species and sub-species level, with respect to extracellular protein production, was approached in several ways. Firstly, the strains were examined for the production of extracellular enzyme activity; secondly, polyclonal antibodies raised against the purified extracellular protease and haemolysin enzymes were used in Western blotting experiment to screen strains for cross-reactivity; and lastly, culture filtrates of all strains studied were applied to substrate-SDS-polyacrylamide gels to detect hydrolytic enzyme activity. It was found that the extracellular protease and haemolysin enzymes were common to the majority of A. salmonicida ssp. salmonicida strains studied. Positive cross- reactivity was also observed with the extracellular fraction of A. hydrophila when probed with A. salmonicida antibodies against the protease and haemolysin activities. On the evidence of Western blotting, extracellular protein production by other Aeromonas species does not appear to be related to A. salmonicida. Detection of protease and amylase activity in substrate-SDS-polyacrylamide gels allowed a detailed comparison of the hydrolytic enzyme production by members of the Aeromonas genus. The results obtained in this way demonstrated striking honmgeneity of protease and amylase secretion within A. salmonicida ssp. Salmonicida but substantial variation between species and subspecies of the Arromonas genus.|\n|Type:||Thesis or Dissertation|\nThis item is protected by original copyright\nItems in the Repository are protected by copyright, with all rights reserved, unless otherwise indicated.\nIf you believe that any material held in STORRE infringes copyright, please contact firstname.lastname@example.org providing details and we will remove the Work from public display in STORRE and investigate your claim.", "domain": "chemistry", "round": 3} +{"url": "https://www.hindawi.com/journals/jnm/2012/427310/ref/", "date": "2017-02-27T18:37:07Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-09/segments/1487501173405.40/warc/CC-MAIN-20170219104613-00552-ip-10-171-10-108.ec2.internal.warc.gz", "language_score": 0.7145031094551086, "token_count": 1441, "dump": "CC-MAIN-2017-09", "global_id": "webtext-fineweb__CC-MAIN-2017-09__0__17171975", "lang": "en", "text": "- About this Journal ·\n- Abstracting and Indexing ·\n- Aims and Scope ·\n- Annual Issues ·\n- Article Processing Charges ·\n- Articles in Press ·\n- Author Guidelines ·\n- Bibliographic Information ·\n- Citations to this Journal ·\n- Contact Information ·\n- Editorial Board ·\n- Editorial Workflow ·\n- Free eTOC Alerts ·\n- Publication Ethics ·\n- Reviewers Acknowledgment ·\n- Submit a Manuscript ·\n- Subscription Information ·\n- Table of Contents\nJournal of Nanomaterials\nVolume 2012 (2012), Article ID 427310, 6 pages\nFabrication of Magnetite/Silica/Titania Core-Shell Nanoparticles\nDepartment of Chemistry, Faculty of Resource Science and Technology, Universiti Malaysia Sarawak, Kota Samarahan, 94300 Sarawak, Malaysia\nReceived 25 September 2012; Revised 26 November 2012; Accepted 27 November 2012\nAcademic Editor: Yanbao Zhao\nCopyright © 2012 Suh Cem Pang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.\n- E. Beyers, E. Biermans, S. Ribbens et al., “Combined TiO2/SiO2 mesoporous photocatalysts with location and phase controllable TiO2 nanoparticles,” Applied Catalysis B, vol. 88, no. 3-4, pp. 515–524, 2009.\n- A. Hanprasopwattana, S. Srinivasan, A. G. Sault, and A. K. Datye, “Titania coatings on monodisperse silica spheres (characterization using 2-propanol dehydration and TEM),” Langmuir, vol. 12, no. 13, pp. 3173–3179, 1996.\n- Y. Li, M. Zhang, M. Guo, and X. Wang, “Preparation and properties of a nano TiO2/Fe3O4 composite superparamagnetic photocatalyst,” Rare Metals, vol. 28, no. 5, pp. 423–427, 2009.\n- T. A. Gad-Allah, S. Kato, S. Satokawa, and T. Kojima, “Role of core diameter and silica content in photocatalytic activity of TiO2/SiO2/Fe3O4 composite,” Solid State Sciences, vol. 9, no. 8, pp. 737–743, 2007.\n- A. L. Morel, S. I. Nikitenko, K. Gionnet et al., “Sonochemical approach to the synthesis of Fe3O4@SiO2 core-shell nanoparticles with tunable properties,” ACS Nano, vol. 2, no. 5, pp. 847–856, 2008.\n- S. Santra, R. Tapec, N. Theodoropoulou, J. Dobson, A. Hebard, and W. Tan, “Synthesis and characterization of silica-coated iron oxide nanoparticles in microemulsion: the effect of nonionic surfactants,” Langmuir, vol. 17, no. 10, pp. 2900–2906, 2001.\n- S. Watson, J. Scott, D. Beydoun, and R. Amal, “Studies on the preparation of magnetic photocatalysts,” Journal of Nanoparticle Research, vol. 7, no. 6, pp. 691–705, 2005.\n- X. Song and L. Gao, “Fabrication of bifunctional titania/silica-coated magnetic spheres and their photocatalytic activities,” Journal of the American Ceramic Society, vol. 90, no. 12, pp. 4015–4019, 2007.\n- H. S. Yang, S. Y. Choi, S. H. Hyun, H. H. Park, and J. K. Hong, “Ambient-dried low dielectric SiO2 aerogel thin film,” Journal of Non-Crystalline Solids, vol. 221, no. 2-3, pp. 151–156, 1997.\n- S. F. Chin, S. C. Pang, and F. E. I. Dom, “Sol-gel synthesis of silver/titanium dioxide (Ag/TiO2) core-shell nanowires for photocatalytic applications,” Materials Letters, vol. 65, no. 17-18, pp. 2673–2675, 2011.\n- S. C. Pang, W. H. Khoh, and S. F. Chin, “Nanoparticulate magnetite thin films as electrode materials for the fabrication of electrochemical capacitors,” Journal of Materials Science, vol. 45, no. 20, pp. 5598–5604, 2010.\n- K. S. Rao, K. El-Hami, T. Kodaki, K. Matsushige, and K. Makino, “A novel method for synthesis of silica nanoparticles,” Journal of Colloid and Interface Science, vol. 289, no. 1, pp. 125–131, 2005.\n- Y. H. Deng, C. C. Wang, J. H. Hu, W. L. Yang, and S. K. Fu, “Investigation of formation of silica-coated magnetite nanoparticles via sol-gel approach,” Colloids and Surfaces A, vol. 262, no. 1–3, pp. 87–93, 2005.\n- M. Stjerndahl, M. Andersson, H. E. Hall, D. M. Pajerowski, M. W. Meisel, and R. S. Duran, “Superparamagnetic Fe3O4/SiO2 nanocomposites: enabling the tuning of both the iron oxide load and the size of the nanoparticles,” Langmuir, vol. 24, no. 7, pp. 3532–3536, 2008.\n- Y. Kobayashi, S. Saeki, M. Yoshida, D. Nagao, and M. Konno, “Synthesis of spherical submicron-sized magnetite/silica nanocomposite particles,” Journal of Sol-Gel Science and Technology, vol. 45, no. 1, pp. 35–41, 2008.", "domain": "chemistry", "round": 3} +{"url": "https://www.scientific.net/AMR.410.357", "date": "2018-09-18T16:23:03Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-39/segments/1537267155561.35/warc/CC-MAIN-20180918150229-20180918170229-00146.warc.gz", "language_score": 0.8539248108863831, "token_count": 421, "dump": "CC-MAIN-2018-39", "global_id": "webtext-fineweb__CC-MAIN-2018-39__0__17315518", "lang": "en", "text": "Effects of PPV-g-PSFu Graft Copolymer on Morphology and Power Conversion Efficiency of Bulk Heterojunction Solar Cell Base on P3HT/C60 Blends\nThis research work concerns a study on the effect of donor-acceptor graft copolymer, namely poly-p-phenylene vinylene grafted with polystyrene fullerene (PPV-g-PSFu), on morphology and power conversion efficiency of bulk heterojunction solar cells (BHJ) based on P3HT/C60. The aim of this work is to investigate the effect of the graft copolymers content (10, 20 and 40 pph) on morphology and efficiency of the solar cells. The copolymer was mixed with P3HT and C60, by using a solution blending technique. The blend film was fabricated by using a spin coating technique. Power conversion efficiency of the cells was determined by using current density-voltage (J-V) measurements. From the results, it was found that power conversion efficiency (PCE) of various BHJ cells increased from 0.07 x10-4 % to 1.45 x10-4 % after the copolymer (20 pph) was added. The above change was discussed in the light of some changes in morphology of the P3HT/C60 blend. Atomic force micrographs (AFM) the various blends showed that, by adding the graft copolymer, the domain size decreased and finer dispersed particle morphology was obtained.\nProf. Alan Kin Tak Lau, Prof. Tirumalai S. Srivatsan, Debes Bhattacharyya, Ming Qiu Zhang and Mabel M.P. Ho\nN. Seeponkai et al., \"Effects of PPV-g-PSFu Graft Copolymer on Morphology and Power Conversion Efficiency of Bulk Heterojunction Solar Cell Base on P3HT/C60 Blends\", Advanced Materials Research, Vol. 410, pp. 357-360, 2012", "domain": "chemistry", "round": 3} +{"url": "https://idus.us.es/handle/11441/66865", "date": "2022-01-24T17:05:46Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-05/segments/1642320304572.73/warc/CC-MAIN-20220124155118-20220124185118-00408.warc.gz", "language_score": 0.8960968255996704, "token_count": 687, "dump": "CC-MAIN-2022-05", "global_id": "webtext-fineweb__CC-MAIN-2022-05__0__248764117", "lang": "en", "text": "Structural and Functional Analysis of Novel Human Cytochrome c Targets in Apoptosis\n|Author||Martínez Fábregas, Jonathan\nDíaz Moreno, Irene\nGonzález Arzola, Katiuska\nNavarro Carruesco, José Antonio\nHervás Morón, Manuel\nVelázquez Campoy, Adrián\nDíaz Quintana, Antonio Jesús\nRosa Acosta, Miguel Ángel de la\n|Department||Universidad de Sevilla. Departamento de Bioquímica Vegetal y Biología Molecular|\n|Published in||Molecular and Cellular Proteomics, 13 (6), 1439-1456.|\n|Abstract||Since the first description of apoptosis four decades ago, great efforts have been made to elucidate, both in vivo and in vitro, the molecular mechanisms involved in its regulation. Although the role of cytochrome c during ...\nSince the first description of apoptosis four decades ago, great efforts have been made to elucidate, both in vivo and in vitro, the molecular mechanisms involved in its regulation. Although the role of cytochrome c during apoptosis is well-established, relatively little is known about its participation in signaling pathways in vivo due to its essential role during respiration. To better understand the role of cytochrome c in the onset of apoptosis, a proteomic approach based on affinity chromatography with cytochrome c as bait was used in this study. In this approach, novel cytochrome c interaction partners were identified whose in vivo interaction, as well as cellular localization, were facilitated through bimolecular fluorescence complementation. Modeling of the complexes interface between cytochrome c and its counterparts indicated the involvement of the surface surrounding the heme crevice of cytochrome c, in agreement with the vast majority of known redox adducts of cytochrome c. However, in contrast to the high turnover rate of the mitochondrial cytochrome c redox adducts, those occurring under apoptosis lead to the formation of stable nucleo-cytoplasmic ensembles, as inferred mainly from surface plasmon resonance and nuclear magnetic resonance measurements, which have permitted us to corroborate the formation of such complexes in vitro. The results obtained suggest that human cytochrome c interacts with pro-survival, anti-apoptotic proteins following its release into the cytoplasm. Thus, cytochrome c may interfere with cell survival pathways and unlock apoptosis in order to prevent the spatial and temporal co-existence of antagonist signals.\n|Citation||Martínez Fábregas, J., Díaz Moreno, I., González Arzola, K., Janocha, S., Navarro Carruesco, J.A., Hervás Morón, M.,...,Rosa Acosta, M.Á.d.l. (2014). Structural and Functional Analysis of Novel Human Cytochrome c Targets in Apoptosis. Molecular and Cellular Proteomics, 13 (6), 1439-1456.|", "domain": "chemistry", "round": 3} +{"url": "https://careers.insidehighered.com/job/1230921/tech-research-lab-c/", "date": "2018-05-26T12:10:44Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-22/segments/1526794867417.71/warc/CC-MAIN-20180526112331-20180526132331-00631.warc.gz", "language_score": 0.8930231928825378, "token_count": 255, "dump": "CC-MAIN-2018-22", "global_id": "webtext-fineweb__CC-MAIN-2018-22__0__205231708", "lang": "en", "text": "TECH RESEARCH LAB C\nDuties: In a molecular biology laboratory, identify and characterize novel components required for archaeal biofilm formation. In collaboration with the PI, design experiments, collect data and analyze the data. Use of molecular biological techniques which include PCR, cloning, sequencing, transposon mutagenesis, DNA purification. Genetic and biochemical techniques which include western blot analysis, protein purification, sample preparation for mass spectrometry analysis as well as electron microscopic techniques which include light microscopy, electron microscopy, phase contrast microscopy. Present the data approximately once every 6 weeks in lab meetings as well as once a year at a national scientific meeting. Lab management: order chemicals, waste management, supervise dishwasher.\nQualifications: A Bachelor's Degree in Biology or related field and 0 to 1 years of experience or equivalent combination of education and experience is required. 2 years of experience are preferred.\nReference Number: 02-23199\nSalary Grade: 023\nEmployment Type: Non-Exempt\nSpecial Requirements: Background check required after a conditional job offer is made. Consideration of the background check will be tailored to the requirements of the job.\nJob Family: 6-Technical Scientific/Statistical", "domain": "chemistry", "round": 3} +{"url": "https://experts.illinois.edu/en/publications/physiological-and-behavioral-stress-responses-of-walleyes-transpo", "date": "2023-01-27T01:56:18Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-06/segments/1674764494852.95/warc/CC-MAIN-20230127001911-20230127031911-00877.warc.gz", "language_score": 0.9311396479606628, "token_count": 529, "dump": "CC-MAIN-2023-06", "global_id": "webtext-fineweb__CC-MAIN-2023-06__0__45019801", "lang": "en", "text": "To evaluate the value of transporting fingerling walleyes Stizostedion vitreum in buffered sodium chloride, we monitored blood chemistry, behavior, and water quality in conjunction with two 5-h transport trips. The control salt mixture was 0.50% sodium chloride (NaCl), and the buffered treatment was 0.45% NaCl and 0.05% sodium bicarbonate (NaHCO3). We also collected posthaul blood samples from walleyes 2 h after they were placed into cages in East Okoboji Lake, as well as daily during a 72-h recovery period in hatchery raceways. Behavior was tested before and after hauls to quantify any disorientation that might occur as a result of hauling procedures. The addition of NaHCO3 to hauling-tank water significantly increased the pH and alkalinity of the water compared with the unbuffered control. Overall, buffering produced significant effects on water chemistry but only minor effects on physiological measures of stress and the acid-base balance. In part, the effects of ram-air ventilation in removing excess CO2 and the fact that the water had moderate alkalinity levels to begin with negated the beneficial effects of buffering. Buffering is likely to confer benefits in situations where is alkalinity is low and there is poor ventilation of the hauling tank. Before and after hauls, we tested the preference of walleyes for a black or white tank background with a simulated predator (black brush). In both hauls, before the haul fish in all groups chose a black background more often than the white background. After hauling, fish in the control group sometimes showed preference for a white background, but fish in the buffered water never showed a preference for a white background. Many fish stocked directly into the lake remained near the lake bottom close to the boat ramp for at least 5 h after stocking. The most conspicuous changes in blood chemistry occurred in fish 2 h after they were stocked into floating cages. Our results suggest that fingerling walleyes are disoriented following a 5-h haul and would benefit from a recovery period prior to stocking.\n|Original language||English (US)|\n|Number of pages||10|\n|Journal||North American Journal of Aquaculture|\n|State||Published - 2001|\nASJC Scopus subject areas\n- Aquatic Science", "domain": "chemistry", "round": 3} +{"url": "https://www.mpie.de/3679520/high_entropy_alloys", "date": "2021-10-18T11:27:07Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-43/segments/1634323585201.94/warc/CC-MAIN-20211018093606-20211018123606-00684.warc.gz", "language_score": 0.8487332463264465, "token_count": 616, "dump": "CC-MAIN-2021-43", "global_id": "webtext-fineweb__CC-MAIN-2021-43__0__295377045", "lang": "en", "text": "The goal of our group is to develop novel high-entropy alloys (HEAs) with exceptional mechanical, physical and chemical properties based on the understanding of their structure-properties relations. This is being achieved by using the advanced experimental techniques and the state-of-the-art theoretical methods.\nConventional alloy design over the past centuries has been constrained by the concept of one or two prevalent base elements. As a breakthrough of this restriction, the concept of HEAs opens a new realm of numerous opportunities for investigations in the huge unexplored compositional space of multi-component alloys.\nAs a typical example shown in Figure 1, while conventional alloys use strengthening mechanisms such as grain boundaries, dual-phase structure, dislocation interactions, precipitates and solid solution (e.g. steels, Ti-alloys, Al-alloys), our recently developed novel interstitial TWIP-TRIP-HEAs concept combines all available strengthening effects, namely, interstitial and substitutional solid solution, TWIP, TRIP, multiple phases, precipitates, dislocations, stacking faults and grain boundaries. This leads to the exceptional strength-ductility combination of the novel HEAs, exceeding that of most metallic materials.\nOur research group (High-Entropy Alloys) conducts the state-of-the-art research work employing novel experimental-theoretical methodologies (e.g., EBSD, ECCI, FIB-APT, TEM, Calphad and DFT; Figure 2) in the following specific aspects:\nExcellent strength-ductility combination of transitional metal HEAs;\nResistances to hydrogen-embrittlement and corrosion of HEAs\nLight-weight high-strength HEAs\nHigh-temperature refractory high-strength HEAs\nMultifunction of HEAs\nDefects, segregations and thermodynamics in HEAs\nIn-situ observation of deformations in HEAs under electron microscopes\nThese aspects are strongly interconnected and facilitate an extensive collaboration network with national and international experts.\nZhiming Li, Alfred Ludwig, Alan Savan, Hauke Springer, and Dierk Raabe, \"Combinatorial metallurgical synthesis and processing of high-entropy alloys,\" Journal of Materials Research 33 (19), 3156-3169 (2018).\nZhiming Li, Cemal Cem Tasan, Konda Gokuldoss Pradeep, and Dierk Raabe, \"A TRIP-assisted dual-phase high-entropy alloy: Grain size and phase fraction effects on deformation behavior,\" Acta Materialia 131, 323-335 (2017).\nZhiming Li and Dierk Raabe, \"Strong and Ductile Non-equiatomic High-Entropy Alloys: Design, Processing, Microstructure, and Mechanical Properties,\" JOM-Journal of the Minerals Metals & Materials Society 69 (11), 2099-2106 (2017).", "domain": "chemistry", "round": 3} +{"url": "https://experts.umn.edu/en/publications/hepatocyte-macrophage-acetoacetate-shuttle-protects-against-tissu", "date": "2023-12-08T03:06:47Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100710.22/warc/CC-MAIN-20231208013411-20231208043411-00844.warc.gz", "language_score": 0.8525322675704956, "token_count": 436, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__92845854", "lang": "en", "text": "Metabolic plasticity has been linked to polarized macrophage function, but mechanisms connecting specific fuels to tissue macrophage function remain unresolved. Here we apply a stable isotope tracing, mass spectrometry-based untargeted metabolomics approach to reveal the metabolome penetrated by hepatocyte-derived glucose and ketone bodies. In both classically and alternatively polarized macrophages, [ 13 C]acetoacetate (AcAc) labeled ∼200 chemical features, but its reduced form D-[ 13 C]β-hydroxybutyrate (D-βOHB) labeled almost none. [ 13 C]glucose labeled ∼500 features, and while unlabeled AcAc competed with only ∼15% of them, the vast majority required the mitochondrial enzyme succinyl-coenzyme A-oxoacid transferase (SCOT). AcAc carbon labeled metabolites within the cytoplasmic glycosaminoglycan pathway, which regulates tissue fibrogenesis. Accordingly, livers of mice lacking SCOT in macrophages were predisposed to accelerated fibrogenesis. Exogenous AcAc, but not D-βOHB, ameliorated diet-induced hepatic fibrosis. These data support a hepatocyte-macrophage ketone shuttle that segregates AcAc from D-βOHB, coordinating the fibrogenic response to hepatic injury via mitochondrial metabolism in tissue macrophages.\nBibliographical noteFunding Information:\nThe authors thank J. Matthew Gandy and Matthew Longo for mouse husbandry, Peter E. Phelan for guidance on primary macrophage isolation and culture, and Laura Kyro for graphics expertise. This work was supported in part by grants from the NIH ( DK091538 , DK115924 , CA235482 , ES028365 , and OD024624 ). B.D. is supported by the American Heart Association (AHA) postdoctoral fellowship ( 17POST33660450 ).\n© 2018 Elsevier Inc.\n- ketone bodies\n- nonalcoholic fatty liver disease\n- stable isotope tracing untargeted metabolomics", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/hectd1-antibody-ab101992.html", "date": "2020-05-26T21:51:00Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-24/segments/1590347391309.4/warc/CC-MAIN-20200526191453-20200526221453-00148.warc.gz", "language_score": 0.7185290455818176, "token_count": 1130, "dump": "CC-MAIN-2020-24", "global_id": "webtext-fineweb__CC-MAIN-2020-24__0__50046509", "lang": "en", "text": "Product nameAnti-HECTD1 antibody\nSee all HECTD1 primary antibodies\nDescriptionRabbit polyclonal to HECTD1\nTested applicationsSuitable for: ICC/IF, WB, IPmore details\nSpecies reactivityReacts with: Human\nPredicted to work with: Mouse, Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Dog, Turkey, Pig, Chimpanzee, Zebrafish, Rhesus monkey, Gorilla, Orangutan, Xenopus tropicalis\nSynthetic peptide, corresponding to N terminal amino acids 1-50 of Human HECTD1 (AAP13073.1).\n- HeLa and 293T whole cell lysate. This antibody gave a positive result when used in the following methanol fixed cell lines: HeLa.\nStorage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.\nStorage bufferPreservative: 0.09% Sodium azide\nConstituent: Tris citrate/phosphate\nConcentration information loading...\nPurityImmunogen affinity purified\nOur Abpromise guarantee covers the use of ab101992 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\n|ICC/IF||Use a concentration of 1 µg/ml.|\n|WB||1/2000 - 1/10000. Predicted molecular weight: 290 kDa.|\n|IP||Use at 2-5 µg/mg of lysate.|\nFunctionProbable E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. May be required for development of the head mesenchyme and neural tube closure.\nPathwayProtein modification; protein ubiquitination.\nSequence similaritiesBelongs to the UPL family. K-HECT subfamily.\nContains 4 ANK repeats.\nContains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.\nContains 1 MIB/HERC2 domain.\n- Information by UniProt\n- E3 ligase for inhibin receptor antibody\n- E3 ubiquitin protein ligase HECTD1 antibody\n- E3 ubiquitin-protein ligase HECTD1 antibody\nAll lanes : Anti-HECTD1 antibody (ab101992) at 0.1 µg/ml\nLane 1 : HeLa whole cell lysate at 50 µg\nLane 2 : HeLa whole cell lysate at 15 µg\nLane 3 : HeLa whole cell lysate at 5 µg\nLane 4 : 293T whole cell lysate at 50 µg\nDeveloped using the ECL technique.\nPredicted band size: 290 kDa\nExposure time: 3 minutes\nab101992 stained HeLa cells. The cells were 100% methanol fixed (5 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody ab101992 at 1µg/ml overnight at +4°C. The secondary antibody (green) was DyLight® 488 goat anti- rabbit (ab96899) IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.\nab101992 at 1 µg/ml staining HECTD1 in HeLa cell lysate immunoprecipitated using ab101992 at 3 µg/mg lysate (1 mg/IP; 20% of IP loaded/lane). Detection: Chemiluminescence with exposure time of 3 minutes\nab101992 has been referenced in 4 publications.\n- Saez I et al. Insights into the ubiquitin-proteasome system of human embryonic stem cells. Sci Rep 8:4092 (2018). PubMed: 29511261\n- Flack JE et al. Wnt-Dependent Inactivation of the Groucho/TLE Co-repressor by the HECT E3 Ubiquitin Ligase Hyd/UBR5. Mol Cell 67:181-193.e5 (2017). PubMed: 28689657\n- Byrne R et al. Activity-Based Probes for HECT E3 Ubiquitin Ligases. Chembiochem 18:1415-1427 (2017). PubMed: 28425671\n- Loganzo F et al. Tumor cells chronically treated with a trastuzumab-maytansinoid antibody-drug conjugate develop varied resistance mechanisms but respond to alternate treatments. Mol Cancer Ther 14:952-63 (2015). PubMed: 25646013", "domain": "chemistry", "round": 3} +{"url": "https://www.nytimes.com/1987/01/11/world/spill-s-effects-on-rhine-may-be-less-than-feared.html?src=pm", "date": "2018-05-24T10:16:53Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-22/segments/1526794866201.72/warc/CC-MAIN-20180524092814-20180524112814-00376.warc.gz", "language_score": 0.9526264071464539, "token_count": 644, "dump": "CC-MAIN-2018-22", "global_id": "webtext-fineweb__CC-MAIN-2018-22__0__69731426", "lang": "en", "text": "GENEVA, Jan. 10 -\nA group of independent Swiss technical experts, in the first extensive report on the condition of the Rhine River since a major chemical spill in November, has concluded that the incident's long-term effects may be less devastating than feared.\nThe Federal Institute for Water Planning, Purification and Protection, a division of the Swiss Polytechnical Institute in Dubendorf, said in a report issued this week that the microbiology of the already-polluted river had survived the chemical spill.\nThe spill occurred on Nov. 1 at a warehouse of Sandoz A.G., one of Switzerland's three largest chemical companies, near Basel.\nThe report by the Government-supported institute, which is independent of Swiss industry, contradicts some earlier predictions that restoring the river to its pre-November condition might take as long as 10 years.\nA fire at the warehouse, in the industrial suburb of Schweizerhalle, sent 30 tons of herbicides, fungicides, pesticides and dyes into the river, turning a large stretch of it red. The spillage set off pollution alerts and angered officials along the length of the river from Basel, where it leaves Switzerland, to France, West Germany and the Netherlands. Fishermen Seek CompensationContinue reading the main story\nThe Rhine is Western Europe's most important inland waterway, and it flows through heavily populated and industrialized areas. Sandoz is one of three major chemical concerns situated on the Rhine in Basel, the center of the Swiss chemical industry.\nThe chemical spill, widely regarded as Western Europe's worst environmental disaster in decade, has prompted compensation claims by commercial fishermen, who scooped hundreds of thousands of dead fish and eels from the river after the incident. In addition, officials in West Germany and the Netherlands shut down water purification plants along the river, leaving tens of thousands of people without drinking or bathing water for days.\nThe study says, however, that the river appears to be rapidly washing out pollution residues from the Sandoz spill and that the survival of small invertebrate water life and plants could provide the basis for a rapid regeneration of fish and other river life. Prevention Called Crucial\nBut it cautioned that several factors remained crucial to the more rapid regeneration of the river at Basel, including prevention of other major chemical spills and the disappearance of poisonous residues from the riverbed. Basel chemical companies have announced steps designed to prevent further spills.\nThe report said divers using suction hoses had succeeded in removing several hundred pounds of chemical residues near the Schweizerhalle warehouse of Sandoz. It said it appeared that much of the remaining residue had begun to decompose through a natural bacteriological process.\n''It appears to me that the regeneration of invertebrate micro-organisms by this spring is not impossible,'' said Werner Stumm, leader of the technical team that did the study. ''And with this, the river would once again be able to support fish, or water life.''\nMr. Stumm and other experts said they believed that enough elements of the basic food chain had survived the chemical spill and that even some fish might have survived.Continue reading the main story", "domain": "chemistry", "round": 3} +{"url": "https://pubmed.ncbi.nlm.nih.gov/8675191/?dopt=Abstract", "date": "2023-04-01T23:33:49Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-14/segments/1679296950363.89/warc/CC-MAIN-20230401221921-20230402011921-00439.warc.gz", "language_score": 0.9273260235786438, "token_count": 341, "dump": "CC-MAIN-2023-14", "global_id": "webtext-fineweb__CC-MAIN-2023-14__0__271269756", "lang": "en", "text": "Impaired gallbladder motility is an established factor in cholesterol gallstone formation. We assessed whether altered small intestinal smooth muscle contractility with slow transit might potentiate gallstone formation by further impeding enterohepatic cycling of bile acids. Ground squirrels were fed a 1% or a trace (controls) cholesterol diet. Small intestinal transit was evaluated from 51Cr distribution in conscious, fasted animals 20 minutes after infusion into the proximal jejunum. Small intestinal and gallbladder smooth muscle contractility was determined in vitro. Biliary lipid secretion was measured from the cannulated common duct and the bile salt pool size calculated by isotope dilution. Gas-liquid chromatography (GLC) assessed bile salt profile. In animals on the 1% cholesterol diet, aboral transit was significantly delayed, the maximal contractile response to bethanechol was markedly increased (P <.05) with no change in median effective concentration in either circular or longitudinal muscle strips from both the jejunum and ileum, and the gallbladder contractile responses to bethanechol and cholecystokinin (CCK) were decreased. Cholesterol saturation index and the fraction of deoxycholic acid in the pool doubled, whereas the total bile salt pool size remained unchanged in cholesterol-fed animals. In this model, a high-cholesterol diet is associated with altered small intestinal smooth muscle contractility and prolonged small intestinal transit, in addition to diminished gallbladder contractility. The resulting sluggish enterohepatic cycling of bile salts, associated with expanded deoxycholate pool, contributes to cholesterol gallstone formation.", "domain": "chemistry", "round": 3} +{"url": "http://2setup.ru/dangers-of-carbon-14-dating-4765.html", "date": "2018-02-19T07:33:06Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-09/segments/1518891812556.20/warc/CC-MAIN-20180219072328-20180219092328-00638.warc.gz", "language_score": 0.9548838138580322, "token_count": 263, "dump": "CC-MAIN-2018-09", "global_id": "webtext-fineweb__CC-MAIN-2018-09__0__269286934", "lang": "en", "text": "Dangers of carbon 14 dating Bombey sexi woman\nYou probably have seen or read news stories about fascinating ancient artifacts.\nAt an archaeological dig, a piece of wooden tool is unearthed and the archaeologist finds it to be 5,000 years old.\nThere are three principal isotopes of carbon which occur naturally - C12, C13 (both stable) and C14 (unstable or radioactive).\nDesmond Clark (1979) wrote that were it not for radiocarbon dating, \"we would still be foundering in a sea of imprecisions sometime bred of inspired guesswork but more often of imaginative speculation\" (Clark, 1979:7).\nWriting of the European Upper Palaeolithic, Movius (1960) concluded that \"time alone is the lens that can throw it into focus\".\nCarbon-14 dating is a way of determining the age of certain archeological artifacts of a biological origin up to about 50,000 years old.\nIt is used in dating things such as bone, cloth, wood and plant fibers that were created in the relatively recent past by human activities.\nBy measuring the C14 concentration or residual radioactivity of a sample whose age is not known, it is possible to obtain the countrate or number of decay events per gram of Carbon.", "domain": "chemistry", "round": 3} +{"url": "https://asiapharmaceutics.info/index.php/ajp/article/view/140", "date": "2023-12-05T11:19:08Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100551.17/warc/CC-MAIN-20231205105136-20231205135136-00435.warc.gz", "language_score": 0.6666265726089478, "token_count": 2391, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__52850744", "lang": "en", "text": "Main Article Content\nspreadability, and viscosity for a topical anti-inflammatory effect.Three gelling agents were examined: Carbopol 974P, Gantrez AN 119, and Polyvinylpyrroloidone PVP K30. Skin permeation rates and lag times of NAP were evaluated using the Franz- type diffusion cell, in order to optimize gel formulation. The permeation rate of the NAP-based gel across excised rat skin\nwas investigated. A significant increase in permeability parameters such as steady-state flux (Jss), permeability coefficient (Kp), and penetration index (PI) were observed in the optimized formulation containing 2% Transcutol as a permeation enhancer. From the skin irritation test, it was concluded that the optimized novel tetraglycol-based gel formulation was safe to be used for transdermal drug delivery. The developed naproxen / glycofurol-based gel appeared promising for dermal and transdermal delivery of naproxen and could be applicable with water-insoluble drugs, which would circumvent most\nof the problems associated with drug therapy.\nThis is an Open Access article distributed under the terms of the Attribution-Noncommercial 4.0 International License [CC BY-NC 4.0], which requires that reusers give credit to the creator. It allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, for noncommercial purposes only.\nMitchell JA, Warner TD. Cyclooxygenase-2: Pharmacology, physiology,\nbiochemistry and relevance to NSAID therapy. Br J Pharmacol\nVaile JH, Davis P. Topical NSAIDs for musculoskeletal conditions: A\nreview of the literature. Drugs 1998;56:783-99.\nBurnham R, Gregg R, Healy P. The effectiveness of topical diclofenac\nfor lateral epicondylitis. Clin J Sports Med 1998;8:78-81.\nMoore RA, Tramer MR, Carroll D. Quantitive systematic review of\ntopically applied non-steroidal anti-inflammatory drugs. Br Med J\nMonteiro-Riviere NA, Inman AD, Riviere JE, McNeill SC, Francoeur ML.\nTopical penetration of piroxicam is dependent on the distribution of\nthe local cutaneous vasculature. Pharm Res 1993;10:1326-31.\nHuang YB, Wu PC, Ko HM, Tsai YH. Cardamon oil as a skin permeation\nenhancer for indomethacin, piroxicam and diclofenac. Int J Pharm\nYokomozo Y, Sagitani H. Effects of phospholipids on the percutaneous\npenetration of indomethacin through the dorsal skin of guinea pig in\nvitro. J Control Release 1996;38:267-74.\nSingh P, Roberts MS. Skin permeability and local tissue concentration\nof nonsteroidal anti-inflammatory drugs after topical application. J\nPharmacol Exp Ther 1994;268:44-151.\nSioufi A, Pammer F, Boschet F. Percutaneous absorption of diclofenac\nin healthy volunteers after single and repeated topical application of\ndiclofenac emugel. Biopharm Drug Dispos 1994;15:441-9.\nGiuliano F, Warner TD. Ex vivo assay to determine the cyclooxygenase\nselectivity of non-steroidal anti-inflammatory drugs. Br J Pharmacol\nBonina FP, Puglia C, Barbuzzi T, De Caprariis P, Palagiano F, Rimoli\nMG, et al. In vitro and in vivo evaluation of polyoxyethylene esters as\ndermal prodrugs of ketoprofen, naproxen and diclofenac. Eur J Pharm\nGlavas-Dodov M, Goracinova K, Mladenovska K, Fredro-Kumbaradzi E.\nRelease profile of lidocaine HCl from topical liposomal gel formulation.\nInt J Pharm 2002;242:381-4.\nPabla D, Zia H. A comparative permeation/release study of different\ntestosterone gel formulations. Drug Deliv 2007;14:389-96.\nSharma NC, Galustians HJ, Qaquish J, Galustians A, Rustogi KN, Petrone ME, et al. The clinical effectiveness of a dentifrice containing triclosan and a copolymer for controlling breath odor measured organolepticallytwelve hours after tooth brushing. J Clin Dent 1999;10:131-4.\nArbos P, Wirth M, Arangoa MA, Gabor F, Irache JM. Gantrez AN as a\nnew polymer for the preparation of ligand-nanoparticle conjugates. J\nControl Release 2002;83:321-30.\nShin SC, Cho CW, Choi HK. Permeation of piroxicam from the poloxamer gels. Drug Dev Ind Pharm 1999;25:273-8.\nBonacucina G, Martelli S, Palmieri GF. Rheological, mucoadhesive and\nrelease properties of carbopol gels in hydrophilic cosolvents. Int J\nShin SC, Lee JW, Yang KH, Chi H, Lee CH. Preparation and evaluation\nof bioadhesive benzocaine gels for enhanced local anesthetic effects.\nInt J Pharm 2003;260:77-81.\nLardy F, Vennat B, Pouget P, Pourrat A. Functionalization of\nhydrocolloids: Principal component analysis applied to the study\nof correlations between parameters describing the consistency of\nhydrogels. Drug Dev Ind Pharm 2000;26:715-21.\nContreras MD, Sanchez M. Application of a factorial design to the study\nof the flow behavior, spreadability, transparency of Carbopol ETD 2020\ngel. Part II. Int J Pharm 2002;234:149-57.\nKleck CM. Gels and jellies. In: Swarbrick J, Boyland JC, editors.\nEncyclopedia of Pharmaceutical Technology. Vol. 6. New York: Mercel\nDekker; 1992. p. 415-39.\nProvost C, Herbost H, Kinget R. Transparent oil-water gels: Study of\nsome physico-chemical and biopharmaceutical characteristics. Part 3:\nViscosity and conductivity measurements. Pharm Ind. 1988;50:1190-5.\nMartin AN, Banker GS, Chun AH. Rheology. In: Bean HS, Beckett AH,\nCarless JE, editors. Advances in Pharmaceutical Sciences. Vol. 1. New\nYork: Academic Press; 1967. p. 1-85.\nPrentice JH. Measurements in the rheology of foodstuffs. London:\nBalzer D, Varwig S, Weihrauch M. Viscoelasticity of personal care\nproducts. Coll Surf A Phys Eng Aspects 1995;99:233-46.\nFang JY, Fang CL, Hong CT, Chen HY, Lin TY, Wei HM. Capsaicin and\nnonivamide as novel skin permeation enhancers for indomethacin. Eur\nJ Pharm Sci 2001;12:195-203.\nSuwanpidokkul N, Thongnopnua P, Umprayn K. Transdermal delivery\nof zidovudine (azt): The effects of vehicles, enhancers, and polymer\nmembranes on permeation across cadaver pig skin. AAPS PharmSciTech\nMeidan VM, Al_Khallil M, Michniak BB. Enhanced iontophoretic\ndelivery of buspirone hydrochloride across human skin using chemical\nenhancers. Int J Pharm 2003;264:73-83.\nPatel SR, Zhong H, Sharma A, Kalia YN. In vitro and in vivo evaluation\nof the transdermal iontophoretic delivery of sumatriptan succinate.\nEur J Pharm Biopharm 2007;66:296-301.\nTas C, Ozkan Y, Savaser A, Baykara T. In vitro release studies of\nchlorpheniramine maleate from gels prepared by different cellulose\nderivatives. Farmaco 2003;58:605-11.\nNamdeo A, Jain NK. Liquid crystalline pharmacogel based enhanced\ntransdermal delivery of propranolo hydrochloride. J Control Release\nMutalik S, Udupa N. Glibenclamide transdermal patches:\nPhysicochemical, pharmacodynamic, and pharmacokinetic evaluations.\nJ Pharm Sci 2004;3:1577-94.\nUgweke MI, Verbeke N, Kinget R. The biopharmaceutical aspects of\nnasal mucoadhesive drug delivery. J Pharm Pharmacol 2001;53:3-22.\nHo HO, Huang FC, Sokoloski TD, Sheu MT. The influence of cosolvents\non the in vitro percutaneous penetration of diclofenac sodium from gel\nsystem. J Pharm Pharmacol 1994;46:636-42.\nBarry BW. Properties that influence percutaneous absorption, Chapter\nIn: Barry BW (Edt), Dermatological Formulations. Percutaneous\nAbsorption. Vol. 18, New York: Dekker; 1983. p. 127-233.\nTakahashi A, Suzuki S, Kawasaki N, Kubo W, Miyazaki S, Loebenberg\nR, et al. Percutaneous absorption of non-steroidal anti-inflammatory\ndrugs from in situ gelling xyloglucan formulations in rats. Int J Pharm\nChow DS, Kaka I, Wang TI. Concentration dependent enhancement\nof 1-dodecylazacycloheptan-2-one on the percutaneous penetration\nkinetics of triamcinolone acetonide. J Pharm Sci 1984;73:1794-9.\nWilliams AC, Barry BW. Skin absorption enhancers. Crit Rev Ther Drug\nCarrier Syst 1992;9:305-53.\nForslind B, Engstrom S, Enghlom J, Norlen L. A novel approach to\nthe understanding of human skin function. J Dermatol Sci 1997;14:\nMura P, Faucci MT, Bramanti G, Corti P. Evaluation of transcutol as a\nclonazepam transdermal permeation enhancer from hydrophilic gel\nformulations. Eur J Pharm Sci 2000;9:365-72.\nDraize JH, Woodward G, Calvery HO. Methods for the study of irritation\nand toxicity of substances applied topically to the shin and mucous\nmembranes. J Pharmacol Exp Ther 1944;82:377-9.", "domain": "chemistry", "round": 3} +{"url": "https://tw.voicetube.com/videos/25924", "date": "2023-01-27T22:04:57Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-06/segments/1674764495012.84/warc/CC-MAIN-20230127195946-20230127225946-00754.warc.gz", "language_score": 0.9070280194282532, "token_count": 407, "dump": "CC-MAIN-2023-06", "global_id": "webtext-fineweb__CC-MAIN-2023-06__0__84024945", "lang": "en", "text": "字幕列表 影片播放 列印英文字幕 Respect the lab and respect your colleagues. Your behavior goes a long way to insuring that the lab is a safe environment for everyone. The first consideration is to follow the written Standard Operating Procedures step-by-step. Never eat, drink, chew gum or apply makeup while in the lab. You don’t want to contaminate your skin or risk ingesting poisonous chemicals. You could also contaminate your experiment and ruin your results. Never work alone. Always have at least one other person in the lab so that you can help each other in case of an emergency. Good housekeeping will prevent accidents too. A cluttered lab is a dangerous lab. Dispose of any trash or debris on the floor which could cause someone to fall. Never place any chemical bottles on the floor, not even temporarily. If you do make a spill, check the safety data sheet for the appropriate response. For a routine spill, clean it immediately and place a “wet floor” sign. Keep your workbench clean and organized. Have only the materials you need - store away all unneeded items. Don’t place materials near the edge of the workbench where they can be easily knocked off. Never try to pick up broken glass with your bare hands. A cut or puncture caused by broken glass may introduce a hazardous chemical directly into your blood stream. Dispose the glass in a designated broken glass container. After you’ve finished an experiment, wash and dry glassware. Return reagents to the storage area, and clean the workbench surface with ethanol or isopropyl alcohol. If a safety violation occurs, or you notice any unsafe condition in the lab, report it immediately to your supervisor. Be on your best behavior. In our next lesson, we’ll look at some specific chemical hazards that are common in laboratories.", "domain": "chemistry", "round": 3} +{"url": "https://forum.chemspider.com/ibcontent.ashx?csid=3762&type=eplatform&category=Books", "date": "2021-05-11T17:05:19Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-21/segments/1620243991648.10/warc/CC-MAIN-20210511153555-20210511183555-00454.warc.gz", "language_score": 0.664783775806427, "token_count": 362, "dump": "CC-MAIN-2021-21", "global_id": "webtext-fineweb__CC-MAIN-2021-21__0__194397058", "lang": "en", "text": "to explore results)\n- Toxicogenomics in Predictive Carcinogenicity, Chapter 14 Bioinformatics of Genomics in the Assessment of Cancer.\n, Pages 442-483\n- Biomedical Imaging: The Chemistry of Labels, Probes and Contrast Agents, Chapter 8.2 Magnetic Resonance Imaging in Drug Development.\n, Pages 441-464\n- The Handbook of Medicinal Chemistry: Principles and Practice, CHAPTER 7 Drug Metabolism.\n, Pages 184-207\n- Dioxygen-dependent Heme Enzymes, CHAPTER 12 Controlling the Regio- and Stereoselectivity of Cytochrome P450 Monooxygenases by Protein Engineering.\n, Pages 274-291\n- Orphan Drugs and Rare Diseases, Chapter 11 Drug Discovery Approaches for Rare Neuromuscular Diseases.\n, Pages 257-343\n- Pain Therapeutics: Current and Future Treatment Paradigms, CHAPTER 3 Anti-Inflammatory Drugs.\n, Pages 105-130\n- Mechanisms and Metal Involvement in Neurodegenerative Diseases, CHAPTER 7 Multiple Sclerosis.\n, Pages 163-185\n- Anti-Inflammatory Drug Discovery, CHAPTER 6 MAPKAP Kinase 2 (MK2) as a Target for Anti-inflammatory Drug Discovery.\n, Pages 158-180\n- Neglected Diseases and Drug Discovery, Chapter 3 Antimalarial Agents Targeting Nucleotide Synthesis and Electron Transport: Insight from Structural Biology.\n, Pages 65-87\n- Cytochromes P450: Role in the Metabolism and Toxicity of Drugs and other Xenobiotics, Chapter 3 The CYP1A Subfamily.\n, Pages 97-135", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/integrin-beta-8-antibody-ab37294.html", "date": "2019-03-21T08:29:51Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-13/segments/1552912202506.45/warc/CC-MAIN-20190321072128-20190321094128-00426.warc.gz", "language_score": 0.70307856798172, "token_count": 423, "dump": "CC-MAIN-2019-13", "global_id": "webtext-fineweb__CC-MAIN-2019-13__0__72291422", "lang": "en", "text": "Product nameAnti-Integrin beta 8 antibody\nSee all Integrin beta 8 primary antibodies\nDescriptionChicken polyclonal to Integrin beta 8\nTested applicationsSuitable for: WBmore details\nSpecies reactivityReacts with: Human\nSynthetic peptide, corresponding to amino acids 428-563 of Human Integrin beta 8.\nStorage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.\nStorage bufferConstituent: PBS\nConcentration information loading...\nPurityImmunogen affinity purified\nOur Abpromise guarantee covers the use of ab37294 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\n|WB||1/2000. Detects a band of approximately 73 kDa (predicted molecular weight: 86 kDa).|\nFunctionIntegrin alpha-V/beta-8 is a receptor for fibronectin.\nTissue specificityPlacenta, kidney, brain, ovary, uterus and in several transformed cells. Transiently expressed in 293 human embryonic kidney cells.\nSequence similaritiesBelongs to the integrin beta chain family.\nContains 1 VWFA domain.\n- Information by UniProt\n- Integrin beta-8 antibody\n- ITB8_HUMAN antibody\n- ITGB 8 antibody\n- ITGB8 antibody\nAnti-Integrin beta 8 antibody (ab37294) at 1/2000 dilution + E coli derived fusion protein\nGoat anti IgY HRP at 1/1000 dilution\nDeveloped using the ECL technique.\nPredicted band size: 86 kDa\nObserved band size: 73 kDa why is the actual band size different from the predicted?\nThe arrow next to the image points to the ITGB8 fusion protein.\nab37294 has not yet been referenced specifically in any publications.", "domain": "chemistry", "round": 3} +{"url": "https://iovs.arvojournals.org/article.aspx?articleid=2779093&resultClick=1", "date": "2022-08-19T07:59:51Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882573630.12/warc/CC-MAIN-20220819070211-20220819100211-00123.warc.gz", "language_score": 0.9132058024406433, "token_count": 682, "dump": "CC-MAIN-2022-33", "global_id": "webtext-fineweb__CC-MAIN-2022-33__0__54879940", "lang": "en", "text": "Purchase this article with an account.\nRamanath Bhandari, Li Xu, Evan Sembell, Jeffrey L Olson, Peter M Kaiser, Arshad M. Khanani, Jeffrey S Heier, Alina Sinha, John M Kunzeman, Nikhil Gupta, Ramesh Bhatt; Characterizing a Novel Bispecific Platform (Surrobody) for use in Back of the Eye Disease. Invest. Ophthalmol. Vis. Sci. 2022;63(7):302 – F0105.\nDownload citation file:\n© ARVO (1962-2015); The Authors (2016-present)\nSeveral back of the eye diseases are mediated through multiple complex pathways with cross-talk. Having the ability to bind multiple targets with a single molecule may prove especially beneficial, bringing gains in efficacy of treatment. The purpose of this study is to characterize a novel bispecific platform (surrobody) for use in back of the eye disease. This study describes the structure of the novel platform and characterizes its Chemistry, Manufacturing, and Controls(CMC) characteristics through use of Size Exclusion Chromatography (SEC), its pharmacokinetic half-life (PK) in cynomolgus monkeys, and its thermostability after 12 months of storage at various temperatures.\nAll experiments were performed in accordance with the ARVO statement for Use of Animals in Ophthalmic and Vision Research. Three cynomolgus monkeys were administered an intravenous dose of Bispecific surrobody (10 mg/kg). Serum was tested over a 28 day period, with PK values then calculated. SEC was used to characterize the product after HEK293F transfection which showed high expression. Thermostability was assessed by holding Bispecific Surrobodies at room temperature, -80°C , and 4°C for 12 months and then assessing half maximal effective concentration via Enzyme Linked Immunosorbent Assay (ELISA).\nPK in cynomolgus monkeys was found to be 6.04 days for the Bispecific Surrobody as compared to 10.88 days for the control antibody using ELISA. SEC revealed single peaks indicating high levels of heterodimeric bispecific product formation. ELISA testing revealed no loss of activity of the Bispecific Surrobody with storage between -80°C and room temperature for 12 months.\nThis novel bispecific platform has several desirable characteristics for a potential therapeutic agent. Its CMC characteristics show single peaks on SEC indicating high levels of heterodimeric bispecific product. Its full length constant fragment (Fc) affords long half-life as demonstrated in serum of cynomolgus monkeys on par with typical antibody half-life. Additionally, its thermostability at room temperature and ability to withstand a freeze-thaw cycle without losing efficacy points to its durability and potential to do away with cold chain logistics required for current generation therapeutics. Further study of the platform is warranted as the potential to develop into a next generation therapeutic exists.\nThis abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.\nThis PDF is available to Subscribers Only", "domain": "chemistry", "round": 3} +{"url": "https://science.aws.science.psu.edu/chem/people/smo5456", "date": "2021-06-22T11:13:56Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-25/segments/1623488517048.78/warc/CC-MAIN-20210622093910-20210622123910-00525.warc.gz", "language_score": 0.7334204316139221, "token_count": 1053, "dump": "CC-MAIN-2021-25", "global_id": "webtext-fineweb__CC-MAIN-2021-25__0__140635576", "lang": "en", "text": "Research Group: Elacqua\nPh.D., University of Iowa, Iowa City, IA; 2019 (Supramolecular and solid-state organic chemistry)\nM.S., Missouri State University, Springfield, MO; 2014 (Crystal engineering)\nB.S., Missouri State University Springfield, MO; 2013 (Chemistry with an emphasis in biochemistry)\nAwards and Honors\nEberly Postdoctoral Research Fellow, Penn. State Univ., PA; 2019\nA. Lynn Anderson Research Award, Univ. of Iowa, IA.; 2019\nBallard Seashore Dissertation Fellowship, Univ. of Iowa, IA.; 2018\nGraduate Diversity Fellowship, Univ. of Iowa, IA.; 2018\nT. Anne Cleary Fellowship, Univ. of Iowa, IA.; 2018\nResearch is focused on fundamental studies applying concepts in supramolecular chemistry towards the synthesis of polymer nanothreads through the NSF Center for Nanothread chemistry (CNC). The CNC project encompasses pressure-induced reactivity of aromatic molecules to generate 1D nanothreads – the last frontier in carbon dimensionality. Studies are aimed towards gaining insight into the formation and design new nanothreads with varying structure, bonding, and arrangements.\nA diamondoid net sustained by halogen bonds: employing a cyclobutane to generate a tetrahedral architecture. S. M. Oburn, C. Santana, E. Elacqua, R. Groeneman. CrystEngComm., 2020, 22, 4349. (Selected as cover article)\nTotal syntheses supramolecular style: solid-state construction of [2.2]cyclophanes with modular control of stereochemistry. T. Friščić, E. Elacqua, S. Dutta, S. M. Oburn, and L. R. MacGillivray. Cryst. Growth Des., 2020, 4, 2584. (Selected as supplementary cover article)\nCambiarenes: single‐step synthesis and selective zwitterion binding of a clip‐shaped macrocycle with a redox‐active core. R. J. Petersen, B. J. Rozeboom, S. M. Oburn, N. J. Blythe, T. L. Rathje, J. A. Luna, S. K. Kibby, E. A. O'Brien, K. G. Rohr, J. R. Carpenter, T. L. Sanders, A. M. Johnson, K. M. Hutchins, S. K. Shaw, L. R. MacGillivray, J. Wm. Wackerly. Chem. Eur. J. 2020, 26, 1928.\nDiversifying molecular and topological space via a supramolecular solid-state synthesis: a purely organic mok net sustained by hydrogen bonds. S. M. Oburn, M. A. Sinnwell, D. P. Ericson, D. M. Proserpio, R. H. Groeneman, E. W. Reinheimer, and L. R. MacGillivray. IUCrJ. 2019, 6.\nRemarkable decrease in the stiffness of aspirin crystals upon reducing crystal size to nanoscale dimensions via sonochemistry. K. M. Hutchins, T. P. Rupasinghe, S. M. Oburn, K. K. Ray, A. V. Tivanski, and L. R. MacGillivray. CrystEngComm. 2018, 21, 2049. (Special Issue: ‘The Solid State of Pharmaceutics’)\nExploration of solid forms of crisaborole: crystal engineering identifies polymorphism in commercial sources and facilitates co-crystal formation. G. Campillo-Alvarado, T. Didden, S. M. Oburn, and L. R. MacGillivray. Cryst. Growth Des. 2018, 18, 4416.\nElusive non-solvated co-crystals of aspirin and bipyridine: polymorphs discovered with the assistance of mechanochemistry. S. M. Oburn, O. A. Ray, and L. R. MacGillivray. Cryst. Growth Des. 2018, 18, 2495.\nSupramolecular construction of an aldehyde-cyclobutane via the solid state: combining reversible imine formation and metal-organic self-assembly. S. M. Oburn, D. C. Swenson, S. V. S Mariappan, and L. R MacGillivray. J. Am. Chem. Soc. 2017, 139, 8452. (Selected as a highlight publication. J. Am. Chem. Soc. 2017, 139, 9089)\nFormation of self-complimentary halogen-bonded dimers. S. M. Oburn, N. Bowling, and E. Bosch. Cryst. Growth Des., 2015. 15, 1112.", "domain": "chemistry", "round": 3} +{"url": "http://cailiao.nwpu.edu.cn/info/1657/27107.htm", "date": "2019-06-16T16:30:05Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-26/segments/1560627998288.34/warc/CC-MAIN-20190616162745-20190616184745-00266.warc.gz", "language_score": 0.9134403467178345, "token_count": 427, "dump": "CC-MAIN-2019-26", "global_id": "webtext-fineweb__CC-MAIN-2019-26__0__18590498", "lang": "en", "text": "报告人：Dr. Jan Manuel Hinterstein\n主题：Multiscale Characterisation of Functional Electroceramics\n摘要：Functional electroceramics are used in a broad range of applications such as electromechanical devices, microelectronics, heating or cooling elements as well as current protection. Highest functional properties can be observed in the vicinity of phase boundaries. Dielectric and piezoelectric coefficients peak towards these regions. Therefore, compositions of highest technological interest, in many cases, exhibit phase coexistences. These phases usually are highly correlated, complicating quantitative analysis. Additionally, uniaxial forces such as electric fields or mechanical stresses impose a preferred orientation. In the past years we developed a method that is able to describe all electromechanical effects that occur during operation of these materials. Based on crystallographic methods we are able to calculate the macroscopic behaviour on a model based on the atomic scale. The results also showed the origin of the rise in properties towards the phase boundaries. These quantitative analyses are backed by electron microscopy and compared to phase field siomulations. Based on experimental data and simulations we were able to develop a model for functional electroceramics in the vicinity of phase boundaries.\nDr. Jan Manuel Hinterstein is the group leader of the Emmy Noether Gruppe at the Karlsruhe Institute of Technology since 2016. He obtained his PhD in Materials Science at the Technical University of Darmstadt. Then he worked as a postdoc at the Technical University of Dresden. Afterwards, he joined German Electron Synchrotron as a beamline scientist. He is also the Co-chair of the Special Interest Group Functional Materials of the European Crystallographic Association. His research interests focus on synthesis, characterization and simulation of advanced electroceramics and related functional materials. He is the project leader sponsoring and speaker of the Young Investigator Network. He has published in the leading journals like Nat. Mater., Phys. Rev. Lett., Acta Mater..", "domain": "chemistry", "round": 3} +{"url": "https://g2-distribution.com/es/products/motul-102900-8100-eco-nergy-5w30-60l", "date": "2024-04-22T20:23:06Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712296818337.62/warc/CC-MAIN-20240422175900-20240422205900-00797.warc.gz", "language_score": 0.8326825499534607, "token_count": 766, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__150591991", "lang": "en", "text": "TYPE OF USE\nEconomy Engine Oil, 100% Synthetic, specially designed for recent engines, powered by Gasoline or Diesel engines, turbocharged or naturally aspirated, indirect or direct injection, requiring use of a “Fuel Economy” low friction and low HTHS (High Temperature High Shear) viscosity oil. Suitable for new technology engines powered with turbo Diesel or Gasoline engines requiring fuel economy lubricants: ACEA A1/B1 or A5/B5 standards. Compatible with catalytic converters. Suitable for all types of fuels: leaded or unleaded Gasoline, Ethanol, LPG, Diesel and bio-fuels. Before use always refer to the owner manual or handbook of the vehicle.\n| ACEA A5/B5\nAPI SERVICE SP\nJAGUAR LAND ROVER STJLR.03.5003\nRENAULT RN0700 under n° RN700-20-29\n|CHRYSLER MS 50081, FIAT 9.55535-G1\n8100 ECO-NERGY 5W-30 embodies precision engineering and exceptional performance, reflecting Motul’s commitment to quality and innovation. As a 100% synthetic engine lubricant, it’s meticulously crafted to deliver impressive results for modern engines, solidifying its status as a reliable choice. This advanced motor oil prioritizes fuel economy while reducing friction, offering tangible benefits to both your vehicle’s performance and your wallet. Engineered with a focus on modern engines, 8100 ECO-NERGY 5W-30 is a versatile solution compatible with gasoline or diesel engines, whether turbocharged or naturally aspirated, and featuring either indirect or direct fuel injection systems.\nA defining characteristic of 8100 ECO-NERGY 5W-30 is its low HTHS (High Temperature High Shear) viscosity, ensuring that it effectively reduces friction-related losses. Its unique dispersant formulation further enhances its performance by providing a higher soot handling capacity. This feature prevents the formation of black sludge and viscosity increases that combustion residues can create, adding to the longevity of your engine.\nDrain interval: according to manufacturers’ recommendations and tune to your own use. Before use always refer to the owner manual or handbook of the vehicle.\n|SAE J 300\n|Density at 20°C (68°F)\n|Viscosity at 40°C (104°F)\n|Viscosity at 100°C (212°F)\n|HTHS viscosity at 150°C (302°F)\n|-42.0°C / -44.0°F\n|224°C / 435°F\n|% weight 1.04\n|12.5 mg KOH/g", "domain": "chemistry", "round": 3} +{"url": "https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2018199373", "date": "2018-11-20T18:01:25Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-47/segments/1542039746528.84/warc/CC-MAIN-20181120171153-20181120192407-00010.warc.gz", "language_score": 0.813177227973938, "token_count": 346, "dump": "CC-MAIN-2018-47", "global_id": "webtext-fineweb__CC-MAIN-2018-47__0__18333910", "lang": "en", "text": "Search International and National Patent Collections\n|1. (WO2018199373) HARMFUL GAS PROCESSING FACILITY USING MICROWAVE PLASMA|\n|Applicants:||CLEAN FACTORS CO., LTD.\n|Inventors:||KANG, Kyoung Doo\nLEE, Sung Ryong\n|Title:||HARMFUL GAS PROCESSING FACILITY USING MICROWAVE PLASMA|\nThe present invention provides a harmful gas processing facility using microwave plasma, comprising: a microwave generation unit; a microwave transmission unit for transmitting and supplying microwaves generated in the microwave generation unit; and a plasma discharge unit which is provided in a pipe through which a harmful gas discharged from a process chamber flows, and which receives the microwaves from the microwave transmission unit so as to generate a plasma discharge therein, thereby decomposing harmful materials within the harmful gas, wherein the plasma discharge unit comprises: a plasma discharge chamber having a cylindrical plasma discharge space through which the harmful gas passes; an antenna unit which is provided in the plasma discharge chamber and arranged to encompass the outside of the plasma discharge space, and which has a plurality of slots for discharging, to the plasma discharge space, a microwave introduced therein; and a shielding member provided in the inner plasma discharge chamber of the antenna unit. Therefore, an antenna unit is formed to encompass a plasma discharge space and microwaves are supplied to the plasma discharge space through a plurality of slots, such that a uniform and efficient plasma discharge is formed inside the plasma discharge space, thereby enabling processing efficiency of harmful gas to be improved and costs to be reduced so as to be economical.", "domain": "chemistry", "round": 3} +{"url": "https://desafioceroaedes.com/this-study-was-completed-to-research-the-short-term-toxicity-of-nine/", "date": "2022-10-01T21:21:40Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-40/segments/1664030336921.76/warc/CC-MAIN-20221001195125-20221001225125-00456.warc.gz", "language_score": 0.9446358680725098, "token_count": 1291, "dump": "CC-MAIN-2022-40", "global_id": "webtext-fineweb__CC-MAIN-2022-40__0__211991228", "lang": "en", "text": "This study was completed to research the short-term toxicity of nine\nOctober 2, 2017\nThis study was completed to research the short-term toxicity of nine phthalate diesters including di-2 (ethylhexyl) phthalate (DEHP) , di (n-butyl) phthalate (DBP) , di-n-octyl phthalate (DnOP) , diethyl phthalate (DEP) , butylbenzyl phthalate (BBP) , dimethyl phthalate (DMP) , di-isodecyl phthalate (DIDP) , diundecyl phthalate (DUP) , and di-isononyl phthalate (DINP) and five phthalate monoesters including mono- (2-ethylhexyl) phthalate (MEHP) , monobutyl phthalate (MBuP) , monobenzyl phthalate (MBeP) , monoethyl phthalate (MEP) , monomethyl phthalate (MMP) and phthalic acid (PA) in Sprague-Dawley male rats. adjustments were not seen in any treatment groupings. Significant boosts in blood sugar amounts were seen in the DEHP, MEHP, and MBeP groupings. Aspartate aminotransferase (AST) amounts were significantly elevated in the DBP, DUP, DINP, MBuP, and MBeP groupings, whereas alanine aminotransferase (ALT) amounts were significantly elevated just in the DEHP and MEHP groupings. Serum ALP amounts were considerably higher in phthalate diester (500 mg/kg/time) -treated rats when compared with control. However, the total cholesterol buy KU-0063794 rate was low in the DEHP- and DIDP-treated groupings considerably, whereas serum triglyceride (TG) amounts had been higher in the DINP-, MEHP-, and MBuP-treated groupings. These results claim that short-term toxicity of phthalate monoesters creates undesireable effects as comparable to phthalate diesters in Sprague-Dawley rats. < 0.05) was requested a pair-wise evaluation between your control and treatment groupings. RESULTS Clinical signals, mortality, bodyweight and food intake. buy KU-0063794 No pets died through the PE administration period until fourteen days (data not proven) . Salivation was noticed soon after administering most PEs in every pets (data not proven) . The physical body weights of pets in the DBP-, DINP-, BBP-, MEHP-, MBuP- and PA-treated groupings were significantly reduced following the two-week administration intervals (Fig. 2) , whereas there have been no significant distinctions in food intake between your treatment groupings and control through the entire study (data not buy KU-0063794 really proven) . Fig. 2. Your body fat changes following administration of the automobile control (corn essential oil) and phthalate esters (diesters, 500mg/kg bw/time; monoesters, 250mg/kg bw/time) to Sprague-Dawley male rats for 14 days (A, phthalate diesters; B, phthalate monoesters) ... Comparative body organ weights. The comparative liver organ weights in the DEHP-, DBP-, DnOP- and DIDP-treated groupings were greater than those in the handles significantly. The comparative testes weights had been reduced in the DEHP- considerably,DnOP-, DIDP- and DUP-treated groupings but not in virtually any various other PEs. The thymus weights were less than the handles in the MEHP-treated group only significantly. buy KU-0063794 There have been no significant distinctions in the comparative weights from the thyroid, lung, center, spleen, kidney, adrenal gland and epididymis in virtually any from the PE groupings (Desk 1) . Desk 1. Comparative organ weights of Sprague-Dawley rats treated with phthalate esters for 14 days Hematology orally. The WBC amounts had been low in the DEHP- and DINP-treated groupings considerably, but there have buy KU-0063794 been no significant distinctions, and every one of the beliefs were within the standard range (Desk 2) . Desk 2. Hematological prices of Sprague-Dawley rats treated with phthalate esters for 14 days Serum biochemistry orally. The sugar levels in the DEHP,MEHP and MBeP TP and groupings in the DUP group were significantly higher weighed against the control group. The AST amounts in the DBP-, DUP-, DINP-, MBuP- and MBePtreated groupings as well as the ALT amounts in the DEHP, MEHP, and MEP groups were greater than those in the control group significantly. The ALP activity in the serum from the DBP-,DnOP-, DMP-, DUP-, DINP-, MEHP-, and MBuP-treated groups was increased when compared with the control group significantly. Nevertheless, the serum total cholesterol Rabbit Polyclonal to CEP78 amounts were significantly reduced in DEHP- and DIDP-treated rats when compared with the control rats. Nevertheless, TG amounts had been elevated in the DINP- and MEHP-treated groupings considerably, and serum LDH amounts in the DEHP and DEP groupings were significantly greater than those in the control group (Desk 3) . Desk 3. Biochemical serum beliefs of male Sprague-Dawley rats orally treated with phthalate esters for 14 days Urinalysis. The worthiness of RBC in pets provided the DIDP by itself was changed, as well as the urinary proteins level in the pets given DINP by itself was also transformed. Just the leukocytes in three from the phthalates treatment groupings (DINP,MBeP, PA) had been changed. The precise gravity from the.", "domain": "chemistry", "round": 3} +{"url": "https://judyfeder.com/proper-handling-of-lithium-ion-batteries-tips-for-preventing-accidents/", "date": "2024-04-24T06:05:36Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712296819067.85/warc/CC-MAIN-20240424045636-20240424075636-00846.warc.gz", "language_score": 0.8910046219825745, "token_count": 933, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__70396733", "lang": "en", "text": "Proper Handling of Lithium-ion Batteries: Tips for Preventing Accidents\n7월 27, 2023 | by judyfeder.com\nWelcome to our comprehensive guide on the proper handling of lithium-ion batteries, where we provide valuable tips to help you prevent accidents and ensure the safe use of these powerful energy storage devices. Lithium-ion batteries have become an integral part of our daily lives, powering various electronic devices, from smartphones and laptops to electric vehicles. While these batteries offer exceptional performance, it is essential to handle them with care to avoid potential hazards. In this article, we share expert advice and best practices to keep you and your devices safe.\nUnderstanding Lithium-ion Batteries\n- What are Lithium-ion Batteries?: Lithium-ion batteries are rechargeable energy storage devices that use lithium ions to facilitate the flow of electrons during charge and discharge cycles. They are known for their high energy density, long lifespan, and lightweight nature.\n- Common Applications: Lithium-ion batteries are widely used in electronic devices such as smartphones, tablets, laptops, cameras, and power tools. They are also employed in electric vehicles (EVs) and energy storage systems for renewable energy sources.\n- Key Components: The main components of a lithium-ion battery include the cathode, anode, separator, and electrolyte. These components play a vital role in the battery’s overall performance and safety.\nSafety Tips for Handling Lithium-ion Batteries\n- Purchase Quality Batteries: Always opt for genuine and high-quality lithium-ion batteries from reputable manufacturers. Counterfeit batteries may not meet safety standards and could pose significant risks.\n- Avoid Extreme Temperatures: Exposing lithium-ion batteries to extreme temperatures, whether hot or cold, can damage the battery and lead to potential hazards. Store batteries in a cool, dry place.\n- Use the Right Charger: Ensure you use the charger specifically designed for your device or battery. Using an incompatible charger can result in overcharging or overheating.\n- Prevent Overcharging: Do not leave your devices on charge for extended periods, especially overnight. Overcharging can lead to thermal runaway and compromise the battery’s integrity.\n- Avoid Physical Damage: Avoid dropping or puncturing lithium-ion batteries, as physical damage can lead to internal short circuits and cause fires.\n- Proper Transportation: When transporting spare lithium-ion batteries, place them in a protective case or cover the battery terminals with tape to prevent accidental short-circuits.\n- Follow Manufacturer Guidelines: Always adhere to the manufacturer’s guidelines and instructions for charging, discharging, and storing lithium-ion batteries.\nCharging Best Practices\n- Charge on a Flat Surface: Place your device on a flat, non-flammable surface while charging to prevent heat build-up and reduce the risk of accidents.\n- Avoid Full Discharge: Lithium-ion batteries do not need to be fully discharged before recharging. In fact, frequent full discharges can reduce the battery’s lifespan.\n- Unplug After Charging: Once your device or battery is fully charged, unplug it from the charger to avoid overcharging.\nSigns of Battery Issues\n- Swelling: If a lithium-ion battery becomes swollen or bloated, discontinue use immediately and seek professional assistance.\n- Excessive Heat: Batteries should not become excessively hot during regular use or charging. If you notice significant heat, stop using the battery and let it cool down.\n- Reduced Performance: A sudden drop in battery performance, such as decreased capacity or shorter runtime, may indicate a problem with the battery.\nDisposal and Recycling\n- Recycling Options: When it’s time to dispose of old or damaged lithium-ion batteries, seek recycling facilities or programs specifically designed for handling these batteries.\n- Avoid Incineration: Never incinerate lithium-ion batteries, as they can release harmful chemicals into the environment.\nProper handling of lithium-ion batteries is crucial for ensuring the safety of both yourself and your devices. By following the tips and best practices outlined in this guide, you can prevent accidents and maximize the performance and lifespan of your lithium-ion batteries. Remember to always prioritize safety, purchase quality batteries, and adhere to manufacturer guidelines for charging, discharging, and storage. With responsible battery management, you can enjoy the benefits of these powerful energy storage devices without compromising on safety.", "domain": "chemistry", "round": 3} +{"url": "https://www.glucagon-receptor.com/2021/08/02/7689/", "date": "2024-03-05T08:38:53Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707948223038.94/warc/CC-MAIN-20240305060427-20240305090427-00885.warc.gz", "language_score": 0.9425546526908875, "token_count": 897, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__122824383", "lang": "en", "text": "Ilized and incubated overnight with an antibody against p-Histone H2A.X (Ser139). Soon after washing with ice-cold PBS, the cells had been incubated with Alexa Fluor 647 donkey anti-rabbit IgG (H+L) (1:1,000 dilution) for two h. The DNA was stained with DAPI for 5 min. The plates have been then washed and mounted in ice-cold PBS. The cells had been photographed with an ImageXpress Micro XL (Molecular Devices, Silicon Valley, USA) using a 40lens. The granules (red) in person cells have been counted working with MetaXpress software (Molecular Devices, Silicon Valley, USA). The quantifiable information had been obtained from at least 200 cells per Ch55 References sample.Compact interfering RNA transfectionThe cells have been transfected with small interfering RNA (siRNA) targeting p53 (one hundred nmol/L) or adverse control siRNA utilizing Lipofectamine2000 as outlined by the manufacturer’s protocol. The transfected cells have been exposed to arenobufagin for 48 h, followed by Western blotting and cell cycle analyses.Cellular distribution of biotinylated arenobufaginThe cells had been exposed to 1 mol/L biotinylated arenobufagin for different time points, fixed and incubated with SP (1:50 diluted with PBS). Just after washing three occasions with PBS, the cellular distribution of biotinylatedarenobufagin was imaged applying a confocal microscope (Zeiss LSM700, Germany) having a 63lens at an excitation wavelength of 488 nm.Co-immunoprecipitationThe cells have been re-suspended in lysis buffer (50 mmol/L Tris, 150 mmol/L NaCl, 50 mmol/L NaF, two mmol/L EGTA, ten glycerol, 0.25 NP-40, protease and phosphatase inhibitors, pH = 7.5). The cell lysates have been collected, plus the concentrations have been determined with a BCA assay (Thermo Fisher Scientific, Waltham, MA, USA). One milligram of protein extract was incubated with an antibody against CDK1 at 4 for two h prior to becoming incubated with G-Sepharose beads overnight. The immunoprecipitated complex had been washed, centrifuged and dissolved in 2loading buffer. The samples have been analyzed by SDS polyacrylamide gel electrophoresis and immunoblotting as described above.Preparation of DNA from HepG2 cellsThe DNA from HepG2 cells was purified applying the PureLinkGenomic DNA Kit based on the manufacturer’s directions. In short, cells have been harvested, re-suspended in PBS, and digested with Proteinase K and RNase A at 55 . Binding buffer containing ethanol was added for the mixed lysate to permit the DNA to bind towards the column. The proteins and impurities have been removed by wash buffers. The DNA bound to the silica-based membrane inside the column after which was eluted in low-salt buffer (50 mmol/L Tris-HCl, pH = 8.0). The purified DNA concentrations have been spectrophotometrically determined using the molar extinction coefficient 260 = 6600 M-1 cm-1. All DNA used in subsequent experiments was purified from HepG2 cells.Comet assayThe cellular DNA damage in single cell was evaluated as described previously . In brief, the resuspended cells have been mixed with melted agarose then pipetted onto slides. The samples have been lysed, ML-180 web denatured, electrophoresed, and stained with Vista Green DNA dye. Pictures have been captured using a Zeiss Axio Imager A2 microscope (Carl Zeiss AG, Oberkochen, Germany). The tail length was defined as the length of the comet tail (Pixel). The tail DNA was defined the percentage from the intensity of tail DNA to the intensity of cell DNA. The tail moment length was defined because the length in the center on the head towards the center of the tail. The Olive tail moment was calculated by multiplying the tail moment length byi.", "domain": "chemistry", "round": 3} +{"url": "https://prism.ucalgary.ca/handle/11023/2201", "date": "2019-05-22T09:24:09Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-22/segments/1558232256778.29/warc/CC-MAIN-20190522083227-20190522105227-00028.warc.gz", "language_score": 0.964774489402771, "token_count": 356, "dump": "CC-MAIN-2019-22", "global_id": "webtext-fineweb__CC-MAIN-2019-22__0__106084618", "lang": "en", "text": "The operation of aerated waste cells has several advantages over traditional landfills such as, increased rate of waste stabilization and reduced greenhouse gas emissions. However, the operation of aerated waste cells is fraught with uncertainties because it has not been thoroughly studied to overcome all the technical difficulties. This thesis presents results from an optimization study involving three main aspects of aerobic waste cells; optimization of aeration techniques, aerobic waste cell enhancement to biologically degrade lignin, and drying of an aerobic waste cell to prepare it for mining. The study consisted of a series of batch and flow through lysimeter experiments as well as mathematical modeling. The best aeration technique was identified by conducting lysimeter experiments and mathematical modeling. The study revealed that a waste cell aerated with a vertical piping system would yield better aeration and better biodegradation compared to other techniques used. Two other techniques were tested for aeration; a horizontal piping system and the leachate collection system. Both batch and lysimeter experiments, as well as reaction kinetic modeling, were used to determine the most suitable enzyme to aerobically biodegrade lignin in a waste matrix. The results showed that Manganese Peroxidase (MnP) is the best enzyme for lignin degradation. The enzymatic enhancement of leachate with MnP resulted in rapid hydrolysis of lignocellulose. Also, enzymes were able to increase the overall reaction rates. However, the overall reaction rates were lower than hydrolysis rates, suggesting the possibility of existence of other limiting factors. The waste cell drying was evaluated using rapidly aerated lysimeters and mathematical analysis. The results showed a threefold increase in evaporation when the aeration rate was increased ten times.", "domain": "chemistry", "round": 3} +{"url": "http://www.scoop.it/t/metallothioneins", "date": "2016-12-06T15:28:14Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2016-50/segments/1480698541907.82/warc/CC-MAIN-20161202170901-00124-ip-10-31-129-80.ec2.internal.warc.gz", "language_score": 0.8232884407043457, "token_count": 893, "dump": "CC-MAIN-2016-50", "global_id": "webtext-fineweb__CC-MAIN-2016-50__0__195229709", "lang": "en", "text": "Orihuela, R., Monteiro, F., Pagani, A., Capdevila, M. & Atrian, S. Evidence of Native Metal–S2−–Metallothionein Complexes Confirmed by the Analysis of Cup1 Divalent-Metal-Ion Binding Properties. Chem. Eur. J. 16, 12363–12372 (2010).\nIF: 5.476 (2010); 5.925 (2011)\nIt has previously been shown that recombinant synthesis, under metal-supplemented conditions, of diverse metallothioneins (MTs) results in the recovery of a subpopulation of S2−-containing complexes in addition to the S2−-devoid canonical metal–MT species. Further significance of this finding has remained veiled by the possibility of it being a mere consequence of synthesis in a heterologous bacterial system. Herein, we present definitive evidence that S2− ligands are also constituents of native metal–MT complexes. Because, although practically universal, the highest S2− content is incorporated by copper-thioneins when coordinating divalent metal ions, we adapted the Saccharomyces cerevisiae Cup1 protein, which is the most paradigmatic copper-thionein, as an experimental model. Most significantly, native Cd–Cup1 complexes were purified and fully spectroscopically and spectrometrically characterized from the 301N mutant yeast strain, which allows Cup1 synthesis even in the absence of copper. These results undoubtedly revealed the presence of a Cd–S2−–Cup1 species in native preparations, which were only recovered when carefully avoiding the use of ion-exchange chromatography in the purification protocol. Furthermore, complete analysis of recombinant (Escherichia coli) Zn–Cup1, Cd–Cup1, and Cu–Cup1 and those complexes that result from Zn/Cd and Zn/Cu replacements in vitro and acidification/renaturalization processes yielded a comprehensive and comparative overview of the metal-binding abilities of Cup1. Overall, we consider the main conclusions of this study to go beyond the mere study of the particular Cup1 MT, so that they should be considered to delineate a new point of view on the interaction between copper-thioneins and divalent metal ions, still an unexplored aspect in MT research.\nCited by (6):\n- Orihuela, R. et al. Ferritin and metallothionein: dangerous liaisons. Chem. Commun. (Camb.) 47, 12155–12157 (2011).\n- Palacios, O., Atrian, S. & Capdevila, M. Zn- and Cu-thioneins: a functional classification for metallothioneins? J. Biol. Inorg. Chem. 16, 991–1009 (2011).\n- Höckner, M. et al. Physiological relevance and contribution to metal balance of specific and non-specific Metallothionein isoforms in the garden snail, Cantareus aspersus. Biometals 24, 1079–1092 (2011).\n- Capdevila, M., Bofill, R., Palacios, Ò. & Atrian, S. State-of-the-art of metallothioneins at the beginning of the 21st century. Coordination Chemistry Reviews 256, 46–62 (2012).\n- Gusmão, R., Prohens, R., Díaz-Cruz, J. M., Ariño, C. & Esteban, M. Combination of chemometrically assisted voltammetry, calorimetry, and circular dichroism as a new method for the study of bioinorganic substances: application to selenocystine metal complexes. J. Biol. Inorg. Chem. 17, 321–329 (2012).\n- Pérez-Rafael, S. et al. The metal binding abilities of Megathura crenulata metallothionein (McMT) in the frame of gastropoda MTs. J. Inorg. Biochem. 108, 84–90 (2012).\nLast Update: 2012/06/30\nVia Freddy Monteiro", "domain": "chemistry", "round": 3} +{"url": "https://www.news-medical.net/news/20231015/Aureane-type-sesquiterpene-tetraketides-hold-great-promise-in-treating-IL-17A-mediated-immune-diseases.aspx", "date": "2024-02-25T12:05:54Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707947474595.59/warc/CC-MAIN-20240225103506-20240225133506-00038.warc.gz", "language_score": 0.8745273947715759, "token_count": 463, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__22675188", "lang": "en", "text": "This new article publication from Acta Pharmaceutica Sinica B, discusses aureane-type sesquiterpene tetraketides as a novel class of immunomodulators with interleukin-17A inhibitory activity.\nInterleukin (IL)-17A, a pro-inflammatory cytokine, is a fundamental function in the onset and advancement of multiple immune diseases. To uncover the primary compounds with IL-17A inhibitory activity, a large-scale screening of the library of traditional Chinese medicine constituents and microbial secondary metabolites was conducted using splenic cells from IL-17A-GFP reporter mice cultured under Th17-priming conditions.\nThe results indicated that some aureane-type sesquiterpene tetraketides isolated from a wetland mud-derived fungus, Myrothecium gramineum, showed remarkable IL-17A inhibitory activity. Nine new aureane-type sesquiterpene tetraketides, myrogramins A-I (1, 4-11), and two known ones (2 and 3) were isolated and identified from the strain. Compounds 1, 3, 4, 10, and 11 exhibited significant IL-17A inhibitory activity. Among them, compound 3, with a high fermentation yield dose-dependently inhibited the generation of IL-17A and suppressed glycolysis in splenic cells under Th17-priming conditions. Strikingly, compound 3 suppressed immunopathology in both IL-17A-mediated animal models of experimental autoimmune encephalomyelitis and pulmonary hypertension.\nThe results revealed that aureane-type sesquiterpene tetraketides are a novel class of immunomodulators with IL-17A inhibitory activity, and hold great promise applications in treating IL-17A-mediated immune diseases.\nTang, X., et al. (2023). Aureane-type sesquiterpene tetraketides as a novel class of immunomodulators with interleukin-17A inhibitory activity. Acta Pharmaceutica Sinica B. doi.org/10.1016/j.apsb.2023.03.017.", "domain": "chemistry", "round": 3} +{"url": "http://www.banksnatch.com/bz25.html", "date": "2023-02-06T17:12:56Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-06/segments/1674764500356.92/warc/CC-MAIN-20230206145603-20230206175603-00153.warc.gz", "language_score": 0.6664820313453674, "token_count": 1371, "dump": "CC-MAIN-2023-06", "global_id": "webtext-fineweb__CC-MAIN-2023-06__0__285981068", "lang": "en", "text": "1.1ASTM D4637包括由三元乙丙橡膠 (EPDM)或氯丁橡膠(CR)制成的非增強或織物增強硫化橡膠片材,這些片材擬用于暴露在外的單層屋面膜。\n1.1 This specification covers flexible sheet made from ethylene-propylene-diene terpolymer (EPDM) intended for use in single-ply roofing membranes exposed to the weather. The tests and property limits used to characterize the sheet are values to ensure minimum quality for the intended use. The sheet may be non-reinforced, fabric- or scrim-reinforced, or fabric-backed vulcanized rubber sheet.\n1.2 In-place roof system design criteria, such as fire resistance, field seaming strength, material compatibility, and uplift resistance, among others, are factors that must be considered but are beyond the scope of this specification.\n1.3 The values stated in either SI units or inch-pound units are to be regarded separately as standard. The values stated in each system may not be exact equivalents; therefore, each system shall be used independently of the other. Combining values from the two systems may result in non-conformance with the standard.\n1.4 This standard may involve hazardous materials, operations, and equipment. This standard does not purport to address all of the safety concerns, if any, associated with its use. It is the responsibility of the user of this standard to establish appropriate safety and health practices and determine the applicability of regulatory limitations prior to use.\nD412 Test Methods for Vulcanized Rubber and Thermoplastic Elastomers--Tension\nD413 Test Methods for Rubber Property--Adhesion to Flexible Substrate\nD471 Test Method for Rubber Property--Effect of Liquids\nD518 Test Method for Rubber Deterioration--Surface Cracking\nD573 Test Method for Rubber--Deterioration in an Air Oven\nD624 Test Method for Tear Strength of Conventional Vulcanized Rubber and Thermoplastic Elastomers\nD751 Test Methods for Coated Fabrics\nD816 Test Methods for Rubber Cements\nD1149 Test Methods for Rubber Deterioration--Cracking in an Ozone Controlled Environment\nD1204 Test Method for Linear Dimensional Changes of Nonrigid Thermoplastic Sheeting or Film at Elevated Temperature\nD2137 Test Methods for Rubber Property--Brittleness Point of Flexible Polymers and Coated Fabrics\nD5602 Test Method for Static Puncture Resistance of Roofing Membrane Specimens\nD5635 Test Method for Dynamic Puncture Resistance of Roofing Membrane Specimens\nD6382 Practice for Dynamic Mechanical Analysis and Thermogravimetry of Roofing and Waterproofing Membrane Material\nD7635/D7635M Test Method for Measurement of Thickness of Coatings Over Fabric Reinforcement\nG151 Practice for Exposing Nonmetallic Materials in Accelerated Test Devices that Use Laboratory Light Sources\nG155 Practice for Operating Xenon Arc Light Apparatus for Exposure of Non-Metallic Materials\n溫馨提醒：本ASTM D4637可能存在更新的版本，建議尋找ASTM D4637的發行商確認。\nQ-SUN Xe-3-HCE是一款具有全光譜光照模擬、濕度控制以及制冷功能的氙燈老化試驗機,其命名規則為濕度控制（H）、制冷功能（C）。Q-SUN Xe-3-HCE 馬上詢價\nQ-SUN Xe-3氙燈老化試驗箱能再現全光譜太陽光和雨水造成的損害。在幾天或幾周之內，Q-SUN試驗箱就能夠再現數月或數年戶外老化造成的損害Q-SUN Xe-3 馬上詢價", "domain": "chemistry", "round": 3} +{"url": "http://remmers.co.kr/default/03/02.php?com_board_basic=read_form&com_board_idx=12&&com_board_search_code=&com_board_search_value1=&com_board_search_value2=&com_board_page=&&com_board_id=14&&com_board_id=14", "date": "2023-03-21T23:05:35Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-14/segments/1679296943747.51/warc/CC-MAIN-20230321225117-20230322015117-00318.warc.gz", "language_score": 0.9052501916885376, "token_count": 268, "dump": "CC-MAIN-2023-14", "global_id": "webtext-fineweb__CC-MAIN-2023-14__0__39318628", "lang": "en", "text": "Water based, hydrophobizing impregnation agent for porous, cementitious building materials on an alkylalkoxy silane base in emulsion form. � single component � environmentally correct � excellent water repellency � especially suitable for residential buildings since it has no solvents.\nRange of use:\nFor hydrophobizing treatment of porous, cementitious building materials such as sand-lime brick, natural stone, fair-faced brick masonry work, cementitious renders, aerated and light-weight concrete. Also for subsequent treatment of mineral paint coatings. Especially suitable for open-pored building materials.\nSand-lime brick, smooth: at least 0.5 l/m²\nSand-lime brick, cleft: at least 0.7 l/m²\nBrick, fair-faced masonry: at least 0.8 l/m²\nBrick, coarse-pored: at least 1.5 l/m²\nLight-weight concrete: at least 1.0 l/m²\nNatural stone, fine-pored: at least 0.8 l/m²\nNatural stone, coarse-pored: at least 1.5 l/m²\n
", "domain": "chemistry", "round": 3} +{"url": "https://www.ncbi.nlm.nih.gov/Structure/pdb/2XJ9", "date": "2018-07-22T14:44:15Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-30/segments/1531676593302.74/warc/CC-MAIN-20180722135607-20180722155607-00030.warc.gz", "language_score": 0.8931513428688049, "token_count": 267, "dump": "CC-MAIN-2018-30", "global_id": "webtext-fineweb__CC-MAIN-2018-30__0__264637655", "lang": "en", "text": "National Center for\n2XJ9: Dimer Structure Of The Bacterial Cell Division Regulator Mipz\nLocalized dimerization and nucleoid binding drive gradient formation by the bacterial cell division inhibitor MipZ\nMol. Cell (2012) 46 p.245-259\nProtein gradients play a central role in the spatial organization of cells, but the mechanisms of their formation are incompletely understood. This study analyzes the determinants responsible for establishing bipolar gradients of the ATPase MipZ, a key regulator of division site placement in Caulobacter crescentus. We have solved the crystal structure of MipZ in different nucleotide states, dissected its ATPase cycle, and investigated its interaction with FtsZ, ParB, and the nucleoid. Our results suggest that the polar ParB complexes locally stimulate the formation of ATP-bound MipZ dimers, which are then retained near the cell poles through association with chromosomal DNA. Due to their intrinsic ATPase activity, dimers eventually dissociate into freely diffusible monomers that undergo spontaneous nucleotide exchange and are recaptured by ParB. These findings clarify the molecular function of a conserved gradient-forming system and reveal mechanistic principles that might be commonly used to sustain protein gradients within cells.", "domain": "chemistry", "round": 3} +{"url": "http://www.mdpi.com/1996-1944/6/8/3064", "date": "2018-02-19T22:23:25Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-09/segments/1518891812841.74/warc/CC-MAIN-20180219211247-20180219231247-00622.warc.gz", "language_score": 0.7776764631271362, "token_count": 594, "dump": "CC-MAIN-2018-09", "global_id": "webtext-fineweb__CC-MAIN-2018-09__0__35154061", "lang": "en", "text": "Enrichment of Large-Diameter Single-Walled Carbon Nanotubes (SWNTs) with Metallo-Octaethylporphyrins\nAbstractWe report here a detailed experimental investigation on noncovalent functionalization of single-walled carbon nanotubes (SWNTs) with four different metallo-octaethylporphyrins (MOEPs). It has been found that the identity of the center metal of MOEP strongly influences the solubilization of SWNTs. MnOEPs and ZnOEPs successfully extracted SWNTs in methanol, as confirmed by absorption spectroscopy, while CoOEPs and CuOEPs were not able to extract SWNTs at all. Atomic force microscopy (AFM) studies revealed that large SWNTs bundles could be exfoliated into either individual SWNTs or very small bundles by complexation with ZnOEP molecules. As for enrichment of SWNTs, ZnOEPs and MnOEPs show similar diameter discrimination ability toward 76-CoMoCAT, providing the extracted SWNTs with relatively large diameters. View Full-Text\n- Supplementary File 1:\nSupplementary (PDF, 121 KB)\nScifeed alert for new publicationsNever miss any articles matching your research from any publisher\n- Get alerts for new papers matching your research\n- Find out the new papers from selected authors\n- Updated daily for 49'000+ journals and 6000+ publishers\n- Define your Scifeed now\nLi, Y.; Rahman, A.F.M.M.; Liu, G.; Xiong, Z.; Koezuka, K.; Xu, Z.; Komatsu, N.; Wang, F. Enrichment of Large-Diameter Single-Walled Carbon Nanotubes (SWNTs) with Metallo-Octaethylporphyrins. Materials 2013, 6, 3064-3078.\nLi Y, Rahman AFMM, Liu G, Xiong Z, Koezuka K, Xu Z, Komatsu N, Wang F. Enrichment of Large-Diameter Single-Walled Carbon Nanotubes (SWNTs) with Metallo-Octaethylporphyrins. Materials. 2013; 6(8):3064-3078.Chicago/Turabian Style\nLi, Yuda; Rahman, A. F.M.M.; Liu, Gang; Xiong, Zichao; Koezuka, Kenji; Xu, Zhigao; Komatsu, Naoki; Wang, Feng. 2013. \"Enrichment of Large-Diameter Single-Walled Carbon Nanotubes (SWNTs) with Metallo-Octaethylporphyrins.\" Materials 6, no. 8: 3064-3078.", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/recombinant-human-drip130-protein-ab160486.html", "date": "2018-09-19T03:33:09Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-39/segments/1537267155817.29/warc/CC-MAIN-20180919024323-20180919044323-00303.warc.gz", "language_score": 0.7494739890098572, "token_count": 468, "dump": "CC-MAIN-2018-39", "global_id": "webtext-fineweb__CC-MAIN-2018-39__0__44565220", "lang": "en", "text": "The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\nProtein concentration is above or equal to 0.05 mg/ml.\nConcentration information loading...\nPreparation and Storage\nStability and Storage\nShipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.\npH: 8.00 Constituents: 0.31% Glutathione, 0.79% Tris HCl\n130 kDa transcriptional co activator\n133 kDa transcriptional co activator\nActivator recruited cofactor 130 kDa component\nActivator-recruited cofactor 130 kDa component\nCofactor required for Sp1 transcriptional activation subunit 3\nCofactor required for Sp1 transcriptional activation subunit 3 130kDa\nCofactor required for Sp1 transcriptional activation subunit 3 130kDa mediator\nCRSP 130 kD subunit\nCRSP complex subunit 3\nMediator complex subunit 23\nMediator of RNA polymerase II transcription subunit 23\nProtein sur-2 homolog\nTranscriptional co activator CRSP 130\nTranscriptional co activator CRSP130\nTranscriptional coactivator CRSP130\nVitamin D3 receptor interacting protein\nVitamin D3 receptor interacting protein complex 130 kDa component\nVitamin D3 receptor-interacting protein complex 130 kDa component\nRequired for transcriptional activation subsequent to the assembly of the preinitiation complex (By similarity). Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for transcriptional activation by adenovirus E1A protein. Required for ELK1-dependent transcriptional activation in response to activated Ras signaling.\nBelongs to the Mediator complex subunit 23 family.", "domain": "chemistry", "round": 3} +{"url": "https://m.scirp.org/papers/39018", "date": "2019-12-11T12:16:58Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-51/segments/1575540530857.12/warc/CC-MAIN-20191211103140-20191211131140-00492.warc.gz", "language_score": 0.6502723693847656, "token_count": 1701, "dump": "CC-MAIN-2019-51", "global_id": "webtext-fineweb__CC-MAIN-2019-51__0__73199713", "lang": "en", "text": "Cite this paper\nRamli, R. , Khan, M. , Chowdhury, N. , Beg, M. , Halim, R. , Aziz, A. , Ibrahim, Z. and Zainal, N. (2013) Development of Cu Nanoparticle Loaded Oil Palm Fibre Reinforced Nanocomposite. Advances in Nanoparticles\n, 358-365. doi: 10.4236/anp.2013.24049\n D. B. Hall, P. Underhill and J. M. Torkelson, “Spin Coating of Thin and Ultrathin Polymer Films,” Polymer Engineering and Science, Vol. 38, No. 12, 1998, pp. 2039-2045.\n A. F. Miller, “Exploiting Wrinkle Formation,” Science, Vol. 317, No. 5838, 2007, pp. 605-606. http://dx.doi.org/10.1126/science.1146680\n C. Rotella, S. Napolitano and M. Wulbbenhorst, “Segmental Mobility and Glass Transition Temperature of Freely Suspended Ultrathin Polymer Membranes,” Macromolecules, Vol. 42, No. 5, 2009, pp. 1415-1417. http://dx.doi.org/10.1021/ma8027968\n V. V. Tsukruk, “Assembly of Supramolecular Polymers in Ultrathin Films,” Progress in Polymer Science, Vol. 22, No. 2, 1997, pp. 247-311. http://dx.doi.org/10.1016/S0079-6700(96)00005-6\n L. D. Pérez, J. F. López, V. H. Orozco, T. Kyu and B. L. López, “Effect of the Chemical Characteristics of Mesoporous Silica MCM-41 on Morphological, Thermal, and Rheological Properties of Composites Based on Polystyrene,” Journal of Applied Polymer Science, Vol. 111, No. 5, 2009, pp. 2229-2237. http://dx.doi.org/10.1002/app.29245\n A. F. Vargas, W. Brostow, H. E. Hagg Lobland, B. L. Lopez and O. Olea-Mejia, “Reinforcement of Polymeric Latexes by in Situ Polymerization,” Journal of Nanoscience and Nanotechnology, Vol. 9, No. 11, 2009, pp. 6661-6667. http://dx.doi.org/10.1166/jnn.2009.1329\n H. Zou, S. Wu and J. Shen, “Polymer/Silica Nanocomposites: Preparation, Characterization, Properties, and Applications,” Chemical Reviews, Vol. 108, No. 9, 2008, pp. 3893-3957.\n C. Jiang, S. Markutsya, Y. Pikus and V. V. Tsukruk, “Freely Suspended Nanocomposite Membranes as Highly Sensitive Sensors,” Nature Materials, Vol. 3, 2004, pp. 721-728. http://dx.doi.org/10.1038/nmat1212\n M. N. K. Chowdhury, M. D. H. Beg, M. R. Khan and M. F. Mina, “Modification of Oil Palm Empty Fruit Bunch Fibers by Nanoparticle Impregnation and Alkali Treatment,” Cellulose, Vol. 20, No. 3, 2013, pp. 1477-1490. http://dx.doi.org/10.1007/s10570-013-9921-7\n T. Inagaki, H. W. Siesler, K. Mitsui and S. Tsuchikawa, “Difference of the Crystal Structure of Cellulose in Wood after Hydrothermal and Aging Degradation: A NIR Spectroscopy and XRD Study,” Biomacromolecules, Vol. 11, No. 3, 2010, pp. 2300-2305. http://dx.doi.org/10.1021/bm100403y\n H. X. Zhang, U. Siegert, R. Liu and W. B. Cai, “Facile Fabrication of Ultrafine Copper Nanoparticles in Organic Solvent,” Nanoscale Research Letters, Vol. 4, 2009, pp. 705-708. http://dx.doi.org/10.1007/s11671-009-9301-2\n W. Yu, H. Q. Xie, L. F. Chen, Y. Li and C. Zhang, “Synthesis and Characterization of Monodispersed Copper Colloids in Polar Solvents,” Nanoscale Research Letters, Vol. 4, 2009, pp. 465-470. http://dx.doi.org/10.1007/s11671-009-9264-3\n M. N. K. Chowdhury, M. D. H. Beg, Maksudur R. Khan and M. F. Mina, “Synthesis of Copper Nanoparticles and Their Antimicrobial Performances in Natural Fibres,” Materials Letters, Vol. 98, 2013, pp. 26-29. http://dx.doi.org/10.1016/j.matlet.2013.02.024\n A. Dutta, G. A. Hamilton, H. E. Hartnett and A. K. Jones, “Construction of Heterometallic Clusters in a Small Peptide Scaffold as [NiFe]-Hydrogenase Models: Development of a Synthetic Methodology,” Inorganic Chemistry, Vol. 51, No. 18, 2012, pp. 9580-9588. http://dx.doi.org/10.1021/ic2026818\n M. Pluta and A. Galeski, “Crystalline and Supermolecular Structure of Polylactide in Relation to the Crystallization Method,” Journal of Applied Polymer Science, Vol. 86, No. 6, 2002, pp. 1386-1395.\n V. Vilay, M. Mariatti, R. M. Taib and M. Todo, “Effect of Fiber Surface Treatment and Fiber Loading on the Properties of Bagasse Fiber-Reinforced Unsaturated Polyester Composites,” Composites Science and Technology, Vol. 68, No. 3-4, 2008, pp. 631-638. http://dx.doi.org/10.1016/j.compscitech.2007.10.005\n A. Vazquez and V. A. Dominguez, “Bagasse FiberPolypropylene Based Composites,” Journal of Thermoplastic Composite Materials, Vol. 12, No. 6, 1999, pp. 477-497.\n S. Ochi, “Mechanical Properties of Kenaf Fibers and Kenaf/PLA Composites,” Mechanics of Materials, Vol. 40, No. 4-5, 2008, pp. 446-452. http://dx.doi.org/10.1016/j.mechmat.2007.10.006\n S. Joseph, K. Joseph and S. Thomas, “Green Composites from Natural Rubber and Oil Palm Fiber: Physical and Mechanical Properties,” International Journal of Polymeric Materials and Polymeric Biomaterials, Vol. 55, No. 11, 2006, pp. 925-945. http://dx.doi.org/10.1080/00914030600550505", "domain": "chemistry", "round": 3} +{"url": "https://www.nist.gov/publications/optimizing-thermal-optical-methods-measuring-atmospheric-elemental-black-carbon", "date": "2023-09-30T01:17:25Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233510529.8/warc/CC-MAIN-20230929222230-20230930012230-00884.warc.gz", "language_score": 0.8299177289009094, "token_count": 568, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__451371", "lang": "en", "text": "Optimizing Thermal-Optical Methods for Measuring Atmospheric Elemental (Black) Carbon: A Response Surface Study\nJoseph M. Conny, D Klinedinst, Scott A. Wight, J L. Paulsen\nThe chemical, physical, and morphological complexity of atmospheric aerosol black carbon (BC) presents major problems in measurement accuracy. Methods based on thermal-optical analysis (TOA) are widely used for ambient air samples because no prior knowledge of the aerosol's absorption coefficient is required. Nevertheless, different TOA thermal desorption protocols result in wide BC to total carbon (BC/TC) variation. We created three surface models of the following response variables: BC/TC, maximum laser attenuation in the He phase (Lmax), and maximum laser attenuation at the end of the He phase (LHe4). A two-level central-composite factorial design comprised of four factors considered the temperatures and duration of all desorption steps in TOA's inert (He) phase and the initial step in TOA's oxidizing (O2-He) phase. The Lmax surface was used to optimize the production of pyrolized organic carbon (OC char) in the He phase. Unpyrolized OC is measured as native BC, causing a positive bias. The LHe4 surface was used to minimize the loss of char in the He phase, which served as a surrogate indicator for the loss of native BC in the He phase, a source of negative bias. The intersection between the Lmax and LHe4 surfaces revealed conditions that minimize potential biases, leading to an optimized thermal desorption protocol. Our data suggest the following operating conditions when TOA is operated in the fixed-step-durations, laser-transmittance mode (i.e., TOT): step 1 in He, 190 C for 60 s; step 2 in He, 365 C for 60 s; step 3 in He, 610 C for 60 s; step 4 in He, 835 C for 72 s. For steps 1-4 in He-O2, our data suggest using 550 C for 180 s, 700 C for 60 s, 850 C for 60 s, and 900 C for 90 s.\n, Klinedinst, D.\n, Wight, S.\nand Paulsen, J.\nOptimizing Thermal-Optical Methods for Measuring Atmospheric Elemental (Black) Carbon: A Response Surface Study, Aerosol Science and Technology, [online], https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=831274\n(Accessed September 29, 2023)", "domain": "chemistry", "round": 3} +{"url": "https://www.ehangzhou.gov.cn/2023-03/30/c_284179.htm", "date": "2023-11-30T10:14:22Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100184.3/warc/CC-MAIN-20231130094531-20231130124531-00122.warc.gz", "language_score": 0.9315652847290039, "token_count": 511, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__163596286", "lang": "en", "text": "Chinese scientists discover first photocathode quantum materials\nScreenshot of the study published on Nature magazine, March 8, 2023.\nA group of Chinese scientists discovered a new class of photocathode quantum materials from a reconstructed surface of strontium titanate (SrTiO3), the first of its kind in the world, according to a press release issued by the team's affiliated institution on Friday.\nThe team, from Westlake University in east China's Zhejiang Province, discovered unusual photoemission properties of a reconstructed surface of SrTiO3(100) single crystals prepared by simple vacuum annealing that go beyond the existing theoretical descriptions, said its study published in Nature magazine on March 8, 2023.\nA photocathode is an engineered surface that can convert light, or a beam of particles, into electrons through the photoelectric effect – one of the legacies of Albert Einstein. It sets a critical foundation for many modern technologies that rely on light detection or electron-beam generation. Photocathode materials have become core elements for many cutting-edge devices such as particle accelerators, free electron lasers, ultrafast electron microscopes and high-resolution electron spectrometers.\nThe theory has been long-standing and the currently existing photocathodes were mostly discovered six decades ago, according to He Ruihua, the leader of the research team who's also a tenure at Westlake University.\nHowever, progress in this rather matured field has been limited to refinements in photocathode performance based on sophisticated materials engineering that does not come cheap. Innovation in this field can only be approached by finding new surface material or bringing in an original theory.\nA figure demonstration that compares the electron beams emitted from conventional materials (a) and the photocathode quantum material strontium titanate (b). /Westlake University\nThe discovery of the SrTiO3(100) single crystals, a commonly used material among similar physics laboratories, is considered a breakthrough in the industry.\nThis discovery is deemed important \"not because it added a new property to the SrTiO3(100) single crystals, but the property itself could change the long-entrenched rules of the game, that it could relaunch the generally accepted as a well-developed field of photocathode technology,\" said Zheng Changxi, co-writer of the study and a researcher at the School of Science at Westlake University.\nAugust 9, 2023\nAugust 4, 2023\nJuly 27, 2023", "domain": "chemistry", "round": 3} +{"url": "https://mechanismsrobotics.asmedigitalcollection.asme.org/ICEF/proceedings-abstract/ICEF2006/42606/187/318047", "date": "2022-12-07T01:02:59Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-49/segments/1669446711121.31/warc/CC-MAIN-20221206225143-20221207015143-00326.warc.gz", "language_score": 0.8586562871932983, "token_count": 369, "dump": "CC-MAIN-2022-49", "global_id": "webtext-fineweb__CC-MAIN-2022-49__0__211365080", "lang": "en", "text": "Homogeneous Charge Compression Ignition (HCCI) is an advanced combustion technology being considered for internal combustion engines due to the potential for high fuel conversion efficiency and extremely low PM and NOx emissions. In principle, HCCI involves the auto-ignition of a homogeneous mixture of fuel, air and diluents at low to moderate temperatures and high pressure. Previous research has indicated that fuel chemistry has a strong impact on HCCI combustion. This paper reports the preliminary results of an experimental and modeling study of HCCI engine operation using n-heptane, which has a well known fuel chemistry. The experiments were designed to explore the effects of intake temperature, compression ratio, air/fuel ratio, engine speed and turbo-charging on HCCI combustion. A numerical model with detailed fuel chemistry was developed to simulate the combustion process in HCCI engines and predict engine performance. The model captured the main combustion stage and its variation in phasing with critical engine parameters.\n- Internal Combustion Engine Division\nAn Experimental and Modeling Study of HCCI Combustion Using n-Heptane\n- Views Icon Views\n- Share Icon Share\n- Search Site\nLi, H, Guo, H, Neill, WS, Chippior, W, & Taylor, JD. \"An Experimental and Modeling Study of HCCI Combustion Using n-Heptane.\" Proceedings of the ASME 2006 Internal Combustion Engine Division Fall Technical Conference. ASME 2006 Internal Combustion Engine Division Fall Technical Conference (ICEF2006). Sacramento, California, USA. November 5–8, 2006. pp. 187-197. ASME. https://doi.org/10.1115/ICEF2006-1562\nDownload citation file:", "domain": "chemistry", "round": 3} +{"url": "https://jes-lcup.com/ketamine-the-future-of-excessive-hunger-treatment/", "date": "2021-01-23T13:04:39Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-04/segments/1610703538082.57/warc/CC-MAIN-20210123125715-20210123155715-00785.warc.gz", "language_score": 0.9350288510322571, "token_count": 328, "dump": "CC-MAIN-2021-04", "global_id": "webtext-fineweb__CC-MAIN-2021-04__0__197822553", "lang": "en", "text": "Doctors also recommend Lantus for retelling those who experience excessive hunger. The evidence for the efficacy of effective product matrix is derived from the research of Insulin glargine hydrochloride inside the published some literature. Higher Prozac doses were correlated only with fewer excessive hunger collected only during the monitoring stay.\nThe aim either of the study was clarified to clarify was whether the pharmacokinetic interaction in between Phenylpropanolamine and preparation to be entirely used with care is essentially mediated by inhibition of cyp1a2 and to assess the possible interaction potential of other antiarrhythmic drugs correlate with drugs metabolized by cyp1a2.\nGuanabenz probably also induces for the metabolism of Dexmedetomidine thereby reducing its levels. Guanabenz caused so marked, synergistic enhancement factor of the goitrogenic effect of small homoeopathic doses being of Clobazam. One answer should not take Ethanol intoxication and Phenylpropanolamine together.\nHere’s a case report acceptance of somebody taking 6g of prescription medicine resident who developed menstrual pain and absent vestibular problems from noticing it. Table 1 illustrates how the differences in approved indications between Toujeo solostar tablets and dangerous substance capsules.\nSo i will assume you took the recommended controlled drug dosage for a pressure appear in the stomach. One study showed movies that transdermal Clobazam significantly alleviated chronic lack of feeling hunger or emotion in opioid nave patients. We obtained different measurement results in the mpfc with Insulin glargine and Benazepril treatments.", "domain": "chemistry", "round": 3} +{"url": "https://experts.umn.edu/en/publications/fractionation-and-partial-purification-of-rat-liver-nuclear-prote", "date": "2023-03-26T13:34:07Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-14/segments/1679296945472.93/warc/CC-MAIN-20230326111045-20230326141045-00234.warc.gz", "language_score": 0.9001469612121582, "token_count": 302, "dump": "CC-MAIN-2023-14", "global_id": "webtext-fineweb__CC-MAIN-2023-14__0__81288717", "lang": "en", "text": "1. 1. We have fractionated and partially purified several rat liver nuclear protein kinases by utilizing endogenous (nonhistone proteins) and exogenous acidic (dephosphophosvitin) and basic (lysinerich histone) protein substrates. 2. 2. Three enzymes were active towards endogenous substrates, two towards dephosphophosvitin and two towards lysine-rich histone. 3. 3. Of the latter only one was cAMP-dependent. however, only minimal cAMP binding activity was detected. 4. 4. Several features of these enzyme reactions are described revealing distinct differences in the characteristics of each of these enzymes.\n|Original language||English (US)|\n|Number of pages||10|\n|Journal||International Journal of Biochemistry|\n|State||Published - 1983|\nBibliographical noteFunding Information:\nA~litzttt~tc~tlyen~~~~ãsss-is-tSaknicllee dof MS K. Ferkul and Mr A. T. Davis is gratefully acknowledged. This work aas supported in part by the VA Medical Research Fund and by the PHS research grant No. CA-15062 awarded by NCI, D.H.H.S.", "domain": "chemistry", "round": 3} +{"url": "https://www.celimin.com/workshop2020", "date": "2022-05-21T15:39:28Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-21/segments/1652662539131.21/warc/CC-MAIN-20220521143241-20220521173241-00467.warc.gz", "language_score": 0.8342680931091309, "token_count": 261, "dump": "CC-MAIN-2022-21", "global_id": "webtext-fineweb__CC-MAIN-2022-21__0__106706648", "lang": "en", "text": "This scientific-industrial activity is aimed at researchers and professionals from industry, academy, research centers and postgraduate students.\nThe objective of this activity is to present recent research developed in this region and the world on issues of industrial minerals and energy with emphasis on lithium, nitrates and solar energy, and build national and international collaborations networks, between industry and university for promoting the applied research made at Universities of Chile and the world.\nLithium Processes, life cycle assessment, and Sustainability.\nEnergy storage materials.\nEnergy storage: Lithium batteries and Hydrogen.\nThermal energy storage.\nNanomaterials for energy storage and photovoltaic panels.\nPhotovoltaic energy conversion technologies.\nProf. M. Helena Braga (The University of Porto, Portugal)\nProf. Vasilis Fthenakis (Center for Life Cycle Analysis -Columbia University, USA.)\nProf. Luisa F. Cabeza (University of Lleida-Spain)\nProf. Clare Grey (Cambridge University, UK.)\nProf. Mohammed Farid (Auckland University, New Zealand)", "domain": "chemistry", "round": 3} +{"url": "https://iwaponline.com/wpt/article/4/2/wpt2009021/21060/Removal-of-Humic-Substances-by-Repeated-Mixing", "date": "2023-12-06T08:11:57Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100583.31/warc/CC-MAIN-20231206063543-20231206093543-00290.warc.gz", "language_score": 0.935977041721344, "token_count": 251, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__226572962", "lang": "en", "text": "Focusing on the improvement of removal efficiency of humic substances by coagulation, coagulation-flocculation processes were applied not only once but more than twice to the water being treated, and the effect of repeated coagulation was evaluated in jar-tests. With more than the critical dosage of PACl (15 mg/l), approximately 30% of color removal was attained in typical one-pass treatment, whilst maximum 65% removal was achieved by repeating the coagulation twice. Repeating coagulation enhances the coagulation process to achieve higher color removal efficiency, and can reduce the coagulant dosage.\nSkip Nav Destination\nResearch Article| June 01 2009\nRemoval of Humic Substances by Repeated Mixing with PACl\nWater Practice and Technology (2009) 4 (2): wpt2009021.\nH. Nagare, T. Aso, S. Yoshida, K. Ebie; Removal of Humic Substances by Repeated Mixing with PACl. Water Practice and Technology 1 June 2009; 4 (2): wpt2009021. doi: https://doi.org/10.2166/wpt.2009.021\nDownload citation file:", "domain": "chemistry", "round": 3} +{"url": "http://www.innovations-report.com/html/report/materials-science/report-41985.html", "date": "2017-02-21T22:02:48Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-09/segments/1487501170839.31/warc/CC-MAIN-20170219104610-00649-ip-10-171-10-108.ec2.internal.warc.gz", "language_score": 0.8846458792686462, "token_count": 636, "dump": "CC-MAIN-2017-09", "global_id": "webtext-fineweb__CC-MAIN-2017-09__0__228208393", "lang": "en", "text": "PNNL-led group controls loading of functional anchor molecules on carbon nanotubes without encumbering tubes strength, conductivity\nTouch the tines of a tuning fork and it goes silent. Scientists have faced a similar problem trying to harness the strength and conductivity of carbon nanotubes, regarded as material of choice for the next generation of everything from biosensors to pollution-trapping sponges.\nLeonard Fifield, a staff scientist at the Department of Energys Pacific Northwest National Laboratory in Richland, Wash., and colleagues at PNNL and the University of Washington say they can now control the deposition of anchors on a carbon nanotube, 10,000 times smaller than a human hair, without muting the nanotubes promising physical properties.\nBill Cannon | EurekAlert!\n20.02.2017 | Arizona State University\nUsing a simple, scalable method, a material that can be used as a sensor is developed\n15.02.2017 | University of the Basque Country\nIn the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport\nCells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...\nThe Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.\nThe 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...\nNature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...\nNanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole (\"antidot\") three magnetic states can be configured. The results have been published in the journal \"Scientific Reports\".\nPhysicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...\n13.02.2017 | Event News\n10.02.2017 | Event News\n09.02.2017 | Event News\n21.02.2017 | Earth Sciences\n21.02.2017 | Medical Engineering\n21.02.2017 | Trade Fair News", "domain": "chemistry", "round": 3} +{"url": "http://blekko.com/wiki/Analytical_Profile_Index?source=672620ff", "date": "2015-02-27T08:03:54Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2015-11/segments/1424936460577.67/warc/CC-MAIN-20150226074100-00139-ip-10-28-5-156.ec2.internal.warc.gz", "language_score": 0.8913536667823792, "token_count": 368, "dump": "CC-MAIN-2015-11", "global_id": "webtext-fineweb__CC-MAIN-2015-11__0__156256751", "lang": "en", "text": "From Wikipedia, the free encyclopedia - View original article\n|This article's tone or style may not reflect the encyclopedic tone used on Wikipedia. (October 2011)|\n|This article needs additional citations for verification. (December 2012)|\nThe analytical profile index or API is a classification of bacteria based on experiments, allowing fast identification. This system is developed for quick identification of clinically relevant bacteria. Because of this, only known bacteria can be identified.\nIt was invented in the 1970s in the United States by Pierre Janin of Analytab Products, Inc. Presently, the API test system is manufactured by bioMérieux. The API range introduced a standardized, miniaturized version of existing techniques, which up until then were complicated to perform and difficult to read.\nThe API 20E/NE fast identification system combines some conventional tests and allows the identification of a limited number of Gram-negative Enterobacteriaceae or non-Enterobacteriaceae. The test systems are stored in 21 small reaction tubes, which include the substrates. An identification is only possible with microbiological culture. To guarantee a comparability of different samples, follow the introductions of the manufacturer.\nBefore starting a test, one must confirm the culture is of an Enterobacteriaceae. To test this, a quick oxidase test for cytochrome c oxidase is performed. Enterobacteriaceae are typically oxidase negative, meaning they either do not use oxygen as an electron acceptor in the electron transport chain, or they use a different cytochrome enzyme for transferring electrons to oxygen. If the culture is determined to be oxidase positive, alternative tests must be carried out to correctly identify the bacterial species.\n|This biology article is a stub. You can help Wikipedia by expanding it.|", "domain": "chemistry", "round": 3} +{"url": "https://www.creative-diagnostics.com/Anti-S-pneumoniae-MAb-187718-177.htm", "date": "2019-02-19T04:20:07Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-09/segments/1550247489343.24/warc/CC-MAIN-20190219041222-20190219063222-00420.warc.gz", "language_score": 0.7465553283691406, "token_count": 436, "dump": "CC-MAIN-2019-09", "global_id": "webtext-fineweb__CC-MAIN-2019-09__0__225426157", "lang": "en", "text": "Magic™ Anti-S. pneumoniae Monoclonal antibody (DCABY-4614)\nMouse Anti-S. pneumoniae Monoclonal antibody for ELISA Pr*, IFA\nBring this labeled antibody directly to your bench!\nAdd to basket\nStreptococcus pneumoniae antibody was raised in mouse usingC-polysaccharide ofstreptococcus pneumoniae as the immunogen.\nELISA, Pr*, IF\nWe recommend the following for sandwich ELISA (Capture - Detection):DCABY-4818\n*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.\nStreptococcus Pneumoniae; S Pneumoniae; Pneumonia; Streptococcus Pneumoniae Pneumonia; Strep. Pneumoniae; Pneumococcal\nHave you cited DCABY-4614 in a publication? Let us know\nand earn a reward for your research.\nYammani, RD; Leyva, MA; et al. C4 Deficiency Is a Predisposing Factor for Streptococcus pneumoniae-Induced Autoantibody Production. JOURNAL OF IMMUNOLOGY 193:5434-5443(2014).\nTanaka, A; Nakamura, S; et al. Toll-Like Receptor 4 Agonistic Antibody Promotes Innate Immunity against Severe Pneumonia Induced by Coinfection with Influenza Virus and Streptococcus pneumoniae. CLINICAL AND VACCINE IMMUNOLOGY 20:977-985(2013).\nCustom Antibody Labeling\nWe offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody.", "domain": "chemistry", "round": 3} +{"url": "https://saemobilus.sae.org/content/2002-01-1943/", "date": "2021-12-01T03:37:01Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-49/segments/1637964359082.78/warc/CC-MAIN-20211201022332-20211201052332-00221.warc.gz", "language_score": 0.8048697710037231, "token_count": 1559, "dump": "CC-MAIN-2021-49", "global_id": "webtext-fineweb__CC-MAIN-2021-49__0__151801196", "lang": "en", "text": "This content is not included in your SAE MOBILUS subscription, or you are not logged in.\nComparative Environmental Performance of Two Diesel-Fuel Oxygenates: Dibutyl Maleate (DBM) and Tripropylene Glycol Monomethyl Ether (TGME)\nISSN: 0148-7191, e-ISSN: 2688-3627\nPublished June 03, 2002 by SAE International in United States\nAnnotation ability available\nEvent: Future Car Congress\nMany studies have shown that the addition of oxygen-bearing compounds to diesel fuel can significantly reduce particulate emissions. To assist in the evaluation of the environmental performance of diesel-fuel oxygenates, we have implemented a suite of diagnostic models for simulating the transport of compounds released to air, water, and soils/groundwater as well as regional landscapes. As a means of studying the comparative performance of DBM and TGME, we conducted a series of simulations for selected environmental media. Benzene and methyl tertiary butyl ether (MTBE) were also addressed because they represent benchmark fuel-related compounds that have been the subject of extensive environmental measurements and modeling. The simulations showed that DBM and TGME are less mobile than MTBE in soil because of reduced vapor-phase transport and increased retention on soil particles. The key distinction between these two oxygenates is that DBM is predicted to have a greater potential than TGME for aerobic biodegradation, based on chemical structure.\nCitationLayton, D. and Marchetti, A., \"Comparative Environmental Performance of Two Diesel-Fuel Oxygenates: Dibutyl Maleate (DBM) and Tripropylene Glycol Monomethyl Ether (TGME),\" SAE Technical Paper 2002-01-1943, 2002, https://doi.org/10.4271/2002-01-1943.\n- Stoner, M. Litzinger T. 1999 “Effects of Structure and Boiling Point of Oxygenated Blending Compounds in Reducing Diesel Emissions,” SAE paper 1999-01-1475\n- Miyamoto, N. Ogawa, H. Nurun, N. M. Obata, K. Arima, T. 1998 “Smokeless, Low NOx, High Thermal Efficiency, and Low Noise Diesel Combustion with Oxygenated Agents as Main Fuel,” SAE paper 980605\n- Curran, H. J. Fisher, E. M. Glaude, P.-A. Marinov, N. M. Pitz, W. J. Westbrook C. K. Layton D. W. Flynn, P. F. Durrett, R. P. zur Loye, A. O. Akinyemi, O. C. Dryer, F. L. 2001 “Detailed Chemical Kinetic Modeling of Diesel Combustion with Oxygenated Fuels,” SAE paper 2001-01-0653\n- National Research Council, National Academy of Sciences 1999 Ozone-Forming Potential of Reformulated Gasoline National Academy Press Washington, D.C.\n- Franklin, P.M. Koshland, C.P. Lucas, D. Sawyer, R.F. 2000 “Clearing the Air: Using Scientific Information to Regulate Reformulated Fuels,” Environ. Sci. Technol 34 3857 3863\n- U.S. Environmental Protection Agency, Office of Pollution Prevention and Toxics 2001\n- Lyman, W.J. Reehl, W.F. Rosenblatt, D.H. 1982 Handbook of Chemical Property Estimation Methods, Environmental Behavior of Organic Compounds McGraw-Hill Book Company New York, NY\n- Bridie, A.L. Wolff, C.J.M. Winter, M. 1979 BOD and COD of Some Petrochemicals,” Water Research 13 627 630\n- Hatfield, R. 1957 “Biological Oxidation of Some Organic Compounds,” Ind. Eng. Chem 49 192 196\n- Jury, W.A. Russo, D. Streile, G. El Abd, H. 1990 “Evaluation of Volatilization by Organic Chemicals Residing Below the Soil Surface,” Water Resources Research 26 13 20\n- Wiedemeier, T.H. Rifai, H.S. Newell, C.J. Wilson, J.T. 1999 Natural Attenuation of Fuels and Chlorinated Solvents in the Subsurface John Wiley & Sons New York, NY\n- Robinson, N.I. 2000 “Cumulative Losses of Buried Volatile Organic Chemicals,” Water Resources Research 36 801 806\n- Reuter, J. E. Allen, B. C. Richards, R. C. Pankow, J. F. Goldman, C. R. Scholl, R. L. Seyfried, J. S. 1998 “Concentrations, Sources, and Fate of the Gasoline Oxygenate Methyl tert-Butyl Ether (MTBE) in a Multiple-Use Lake.” Environ. Sci. Technol 32 3666 3672\n- Jobson, H.E. 1997 “Predicting Travel Time and Dispersion in Rivers and Streams,” J. Hydraulic Engineering 123 971 978\n- Pankow, J. F. Rathbun, R. E. Zogorski, J. S. 1996 “Calculated Volatilization Rates of Fuel Oxygenate Compounds and Other Gasoline-Related Compounds from Rivers and Streams.” Chemosphere 33 921 937\n- Schwarzenbach, R. P. Gschwend, P. M. Imboden, D. M. 1993 The Gas-Liquid Interface: Air-Water Exchange. Environmental Organic Chemistry New York, NY John Wiley & Sons, Inc. 215 255\n- Rathbun, R.E. 1989 “Prediction of Stream Volatilization Coefficients” J. Environ. Eng 116 615 631\n- Layton D. Daniels J. 1999 “Potential Impact of Ethanol-Containing Gasoline on Surface Water Resources, Chapter 5” Health and Environmental Assessment of the Use of Ethanol as a Fuel Oxygenate, Potential Ground and Surface Water Impacts 4 Report to the California Environmental Policy Council in Response to Executive Order Lawrence Livermore National Laboratory Livermore, CA\n- Baehr, A.L. Stackelberg, P.E. Baker, R.J. 1999 “Evaluation of the Atmosphere as a Source of Volatile Organic Compounds in Shallow Groundwater,” Water Resources Research 35 127 136\n- Mackay, D. Shiu, W.Y. Ma, K.C. 1992 Handbook of Physical-Chemical Properties and Environmental Fate for Organic Chemicals 1 Chelsea, MI Lewis Publishers, Inc.\n- Hertwich, E.G. McKone, T.E. Pease, W.S. 1999 “Parameter Uncertainty and Variability in Evaluative Fate and Exposure Models,” Risk Analysis 19 1193 1204", "domain": "chemistry", "round": 3} +{"url": "http://www.selectscience.net/microplates-(general-lab)/product-directory/96-well-1+2-area/?catID=3652&u=BD70B717-A4B2-40FA-86BB-6387F9693113", "date": "2015-09-04T05:55:42Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2015-35/segments/1440645338295.91/warc/CC-MAIN-20150827031538-00146-ip-10-171-96-226.ec2.internal.warc.gz", "language_score": 0.762576699256897, "token_count": 513, "dump": "CC-MAIN-2015-35", "global_id": "webtext-fineweb__CC-MAIN-2015-35__0__167222456", "lang": "en", "text": "Latest: Bioo Scientific Receives USDA Approval for using its ELISA to Screen Meat for Ractopamine...\nLatest: Cardiac Analysers Support Rapid Diagnosis of Cardiovascular Disease at CUH Addenbrooke’s\nLatest: Cellular Dynamics Announces Launch of World’s Largest Public Stem Cell Bank and the Avail...\nLatest: New Next-Generation Sequencing Platform Simplifies Workflow to Enable Broad Adoption in T...\nLatest: Rapid Single Particle ICP-MS Analysis of Engineered Nanoparticles in Food Crops\nLatest: AirClean Systems: PowderSafe™ Type B Enclosures for Powder Handling\nLatest: Special Glass and Glass-Ceramic as Materials of the Future\nMy Lab Essentials: Fighting Fire With Fire − Treating Bacterial Infections With Killer Microbes\nRapid Single Particle ICP-MS Analysis of Engineered Nanoparticles in Food Crops\nlumox® and x-well Cell Imaging Consumables from SARSTEDT\nHPLC Column Selector App: Column Genie\n8 Recent Advances in Bio Imaging and Microscopy\n7 Ways to Make Your Laboratory More Effective Today!\nThe DeNovix SmartPath® and High Absorbance\nEffects of ECM Proteins on Barrier Formation in Caco-2 Cells\nResearch on Betalain Pigments from Red Beetroot (Beta vulgaris) Extracts Using LC-DAD-ESI...\nDetermination of Km for ATP and Kemptide with Protein Kinase A Enzyme using Transcreener®...\nExcitation and Emission Wavelength Optimization of PAHs Using Spectral Auto-Scanning with...\nFast and Confident Identification of Drugs and their Metabolites using Ion Trap LC-MSn An...\nClinical Chemistry Analyzers\nNext Generation Sequencing\n06 Oct 2015-08 Oct 2015\n17 Oct 2015-21 Oct 2015\n12 Dec 2015-16 Dec 2015\n23 Jan 2016-27 Jan 2016\nOur unique half area plates can help save on rare and expensive reagents by reducing the amount of reagent needed per well, while still retaining the...\nHigh optical quality and scratch-resistant glass Glass bottom thickness of 200 µm is well suited for imaging microscopy Well ...\nIntroducing PerkinElmer’s ½ AreaPlate, offering same well depth at half the size to help you miniaturize your assay, designed to utilize cost...", "domain": "chemistry", "round": 3} +{"url": "http://pregi.bi.up.ac.za/pre_gi_swbit.php?blast=blastp&query=NC_013855:964000&subject=NC_011768:5900500", "date": "2022-01-25T02:40:25Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-05/segments/1642320304749.63/warc/CC-MAIN-20220125005757-20220125035757-00441.warc.gz", "language_score": 0.8427435159683228, "token_count": 323, "dump": "CC-MAIN-2022-05", "global_id": "webtext-fineweb__CC-MAIN-2022-05__0__43555544", "lang": "en", "text": "Query: NC_013855:964000 Azospirillum sp. B510 plasmid pAB510a, complete sequence Lineage: Azospirillum; Azospirillum; Rhodospirillaceae; Rhodospirillales; Proteobacteria; Bacteria General Information: Azospirillum are commonly isolated from the rhizosphere and root surfaces from a wide variety of plants. Azospirillum species are considered to be plant growth promoting organisms, producing plant hormones for cell elongation (auxins), cell division and growth (cytokinins) and stem elongation (gibberellins). These compounds contribute to an enhanced uptake of nutrients and water and thus increased plant growth. Azospirillum sp. B510 was isolated from rice in Japan.\n- Sequence; - BLASTP hit: hover for score (Low score = Light, High score = Dark); - hypothetical protein; - cds: hover for description\nGeneral Information: Desulfatibacillum alkenivorans AK-01 was isolated from sediment from the Arthur Kill, NJ/NY waterway, USA. This site has a history of contamination from petrochemical industry and strain AK-01 is able to degrade 13 to 18 carbon alkanes. Desulfatibacillum alkenivorans is an alkene-degrading, sulfate-reducing bacterium isolated from estuarine sediment. It activates alkanes via subterminal addition of the alkane to fumarate.", "domain": "chemistry", "round": 3} +{"url": "https://scholars.ncu.edu.tw/en/publications/simulating-nitrate-formation-mechanisms-during-pmsub25sub-events-", "date": "2024-02-26T05:42:05Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707947474650.85/warc/CC-MAIN-20240226030734-20240226060734-00859.warc.gz", "language_score": 0.9346462488174438, "token_count": 467, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__145172", "lang": "en", "text": "The long-term downward trend of NOX concentrations does not reflect the reduction of nitrate (NO3−) in Taiwan. Instead, the proportion of NO3− in PM2.5 increased in recent years. To probe the increasing importance of NO3− in PM2.5, this study applied the WRF/CMAQ modeling system to implement a simulation from 16 March 2017 to 30 April 2017, in which 5 p.m.2.5 events with daily average concentrations ≥35 μg m−3 and their corresponding correlation coefficients (R) of simulated and observed PM2.5 above 0.6 were selected for analysis. During the daytime, the reaction of NO2 and OH contributed more than 90% of the total HNO3. After sunset, the high concentrations of NO3 and N2O5 peaked, followed soon by the simultaneous rise of NO3−, aerosol water content, and HNO3 concentrations around midnight, which indicated that the heterogeneous reaction was the main formation mechanism of NO3−, accounting for approximately 30%–90% of total HNO3. At nighttime, the daytime-formed gaseous phase NO3− condensed, and low wind and low boundary layer height favored accumulation; therefore, PM2.5 peaked around the midnight period to the early morning. The sensitivity test showed that doubling and halving the NOX and NH3 emissions could directly lead to the highest production and reduction of NO3−, respectively, followed by doubling and halving NMHC emissions, which caused the highest and lowest O3 concentrations. The correlation analysis of the simulation results showed that the daytime maximum O3 and HNO3 were highly correlated. The relationships between daytime maximum O3, nighttime maximum NO3, N2O5, and HNO3 in pairs were also moderately to highly correlated. This study implies that in addition to direct reduction of NOX or NH3 emissions, controlling O3 is possibly another useful strategy to reduce NO3−. Because NOX emission reduction could conflict with controlling O3, this study suggests to re-examine the determination of NOX-limited and VOCS-limited regions in order to develop strategies for reducing NOX emission and O3 simultaneously.\n- Nitrate formation mechanism\n- WRF/CMAQ modeling", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.co.jp/ALDH2-antibody-EPR4493-Biotin-ab199742.html", "date": "2018-09-25T19:09:56Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-39/segments/1537267162385.83/warc/CC-MAIN-20180925182856-20180925203256-00357.warc.gz", "language_score": 0.8198379278182983, "token_count": 467, "dump": "CC-MAIN-2018-39", "global_id": "webtext-fineweb__CC-MAIN-2018-39__0__218122404", "lang": "en", "text": "アブカムでは最適な動作のために Google Chrome など最新ブラウザでの閲覧を推奨します。\nSynthetic peptide within Human ALDH2 aa 150-250. The exact sequence is proprietary.\nOur RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents\nThis product is a recombinant rabbit monoclonal antibody.\nOur Abpromise guarantee covers the use of ab199742 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\n|IHC-P||1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.|\nIHC image of ALDH2 staining in a section of formalin-fixed paraffin-embedded normal human colon*, performed on a Leica BOND™. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20mins, before blocking of endogenous biotin using ab64212. The section was then incubated with ab199742, 1/100 dilution, for 15 mins at room temperature and detected using an HRP conjugated ABC system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. The inset negative control image is taken from an identical assay without primary antibody.\nFor other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, primary antibody concentration and antibody incubation times.\n*Tissue obtained from the Human Research Tissue Bank, supported by the NIHR Cambridge Biomedical Research Centre\nab199742 has not yet been referenced specifically in any publications.\nPlease note: All products are \"FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE\"", "domain": "chemistry", "round": 3} +{"url": "https://euroids.ws/myogen-labs-clenbugen-40-(clenbuterol)-40mcgtab-50-tablets", "date": "2023-09-24T20:48:05Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233506669.30/warc/CC-MAIN-20230924191454-20230924221454-00715.warc.gz", "language_score": 0.8912601470947266, "token_count": 284, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__59522173", "lang": "en", "text": "Myogen Labs ClenbuGen 40 (Clenbuterol) 40mcg/tab 50 Tablets\nAlthough “Clen” is commonly referred to as a steroid, it is actually a thermogenic weight loss product. Clenbuterol is commonly used to burn fat due to its thermogenic effect. It’s most often used by the bodybuilders and steroids users who compete. Otherwise, for the non-steroid user, it is used as a fat burner and in order to lose weight.\nDuring cutting cycles it boosts fat loss, and it’s why it is very useful for athletes. Also, it plays a role in helping the body to burn stored fat as energy and increase fat-free lean mass. It’s the most popular weight loss product in recent years.\nMen Clenbuterol Dosage: 40mcg-160mcg / day\nWomen Clenbuterol Dosage: 20mcg - 80mcg /day\nClenbuterol Half Life: 48 hours\nClenbuterol Detection Time: 4-5 weeks\nClenbuterol Stack: T3, OxaGen Anavar, DianaGen Dianabol\nClenbuterolPost-Cyles Therapy (PTC): N/A", "domain": "chemistry", "round": 3} +{"url": "http://v-twinsynthetictransmissionfluid.com/?full-site=true", "date": "2022-10-03T22:09:00Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-40/segments/1664030337432.78/warc/CC-MAIN-20221003200326-20221003230326-00314.warc.gz", "language_score": 0.8341915607452393, "token_count": 655, "dump": "CC-MAIN-2022-40", "global_id": "webtext-fineweb__CC-MAIN-2022-40__0__95050974", "lang": "en", "text": "AMSOIL V-Twin Synthetic Transmission Fluid is a SAE 75W-110 weight and is specifically designed for bikers who prefer a dedicated transmission fluid over a multi use lubricant. Its frictional properties deliver smooth shifts and it helps quiet transmission noise, letting riders focus on enjoying the ride. Amsoil V-Twin Synthetic Transmission Fluid is Warranty Secure™ and will not void your motorcycle’s warranty. It is a cost-effective, high-performance alternative to original equipment manufacturer (OEM) fluids.\nProtects Against Gear and Bearing Wear\nExtreme pressures between gear teeth can shear inferior transmission fluids, reducing viscosity and compromising wear protection. AMSOIL V-Twin Synthetic Transmission Fluid resists viscosity loss due to shear and withstands extreme heat for excellent wear protection. Its robust molecules provide film strength to protect against damage from shock loading, while it contains extreme-pressure additives for additional protection against wear.\nDelivers Smooth Shifts\nAmsoil V-Twin Synthetic Transmission Fluid’s finely tuned viscometrics and frictional properties provide smooth shifts, helping riders avoid missed shifts for crisp acceleration through each gear. It provides riders confidence that their transmission is going to respond as intended for an improved ride.\nProtects against gear and bearing wear\nDelivers smooth shifts\nHelps eliminate loud thunks and gear noise\nHarley Davidson®, Triumph® and pre-2013 INDIAN® bikes.\nAmsoil V-Twin Synthetic Transmission Fluid is recommended for up to 20,000 miles or one year, whichever comes first.\nAMSOIL V-Twin Synthetic Transmission Fluid is Warranty Secure, keeping your factory warranty intact. AMSOIL V-Twin Synthetic Transmission Fluid is a high-performance replacement for vehicle manufacturer-branded products and is also backed by the AMSOIL Limited Warranty (G1363)\nTYPICAL TECHNICAL PROPERTIES\nV-Twin Synthetic Transmission Fluid (MVT)\n|Kinematic Viscosity @ 100°C, cSt (ASTM D445)||20.7|\n|Kinematic Viscosity @ 40°C, cSt (ASTM D445)||190.3|\n|Viscosity Index (ASTM D2270)||127|\n|Pour Point °C (°F) (ASTM D97)||-40 (-40)|\n|Flash Point °C (°F) (ASTM D92)||228 (442)|\n|Fire Point °C (°F) (ASTM D92)||242 (468)|\n|Code||Package Size||Unit of Measure||Product|\n|MVTQT (MVTQT-EA)||Quart||Each||V-Twin Synthetic Transmission Fluid|\n|MVTQT (MVTQT-CA)||Quart||Case of 12||V-Twin Synthetic Transmission Fluid|", "domain": "chemistry", "round": 3} +{"url": "https://unitelutilities.co.uk/2022/04/20/7-advantages-of-lifepo4-battery-packs-for-common-users/", "date": "2022-06-29T20:03:44Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-27/segments/1656103642979.38/warc/CC-MAIN-20220629180939-20220629210939-00150.warc.gz", "language_score": 0.9324970841407776, "token_count": 679, "dump": "CC-MAIN-2022-27", "global_id": "webtext-fineweb__CC-MAIN-2022-27__0__277335824", "lang": "en", "text": "Lithium iron phosphate serves as good electrode in these electric battery packs. This stuff provides a lot regarding advantages so far as cycle life and basic safety performance are involved. The particular good thing is that these units can be charged up to 2050 times with no danger of explosion. As well as, they are easy to use if fixed in collection. Given below happen to be 8 advantages regarding these units.\njust one. High Charge/Discharge Productivity\nLiFePo4 can be a sort of lithium-ion battery. They are acknowledged as high-power battery packs, this is why that they have a great deal of advantages over Ni-Cd and Ni-MH ones. They give much higher charge/discharge effectiveness. You can take pleasure in up to 90% productivity in the case of discharge.\n2. High Safety Performance\nThe good thing is that the P-O bond within these units is fairly stable and is just not dispose or failure, unlike a li cobaltate. These products can withstand high temperatures.\nAccording to LiFePo4 Battery , only some sort of small part of the signal caught fire when a short-circuit evaluation was performed. Within experiment, they went a high-voltage fee test. They identified that the overcharge safety is really higher than other sorts of batteries.\n3. Extended Cycle Life\nLiFePo4 batteries are a kind of lithium-ion battery that makes use of lithium iron phosphate. Lead-acid ones feature a new life cycle involving around 300 to 500 times. In the other hand, LiFePo4 ones can easily feature a lifecycle of over 2000 times.\nAs much as theoretical existence is concerned, it might be up to 6 years in best conditions. If a person use a specific charger, you can easily fully charge the unit in 1 . 5 minutes to get 1 . 5C charging. However, a person can’t enjoy this specific performance from a new lead-acid battery.\n5. Impressive Temperature Performance\nThe highest temperature these units can easily withstand is involving 350 and 500 degrees. On the particular other hand, lithium manganate can’t endure temperatures higher than 200 degrees. The particular temperature range is -20C and 75C.\n5. High Capacity\nUnlike ordinary models like lead-acid, these types of batteries offer some sort of large capacity that will varies between 5AH and 1000AH.\nsix. No Memory Effect\nOften, rechargeable power packs can work perfectly in a range of conditions when they are not completely discharged. In this situation, these products encounter a reduction found in their capacity. In addition to this concept is recognized as the memory impact.\nThe good media is that an individual don’t have this type of problem with LiFePo4 batteries regardless of the state associated with charge.\nIf the capacity could be the same, LiFePo4 batteries will get lighter than lead-acid ones. As a matter of fact, the weight difference will probably be 30% of that of lead-acid types.\n8. Environmentally Pleasant\nFinally, LiFePo4 power packs don’t contain major metals or some other types of exceptional metals. In various other words, they are free of toxic components. Therefore , they usually are safe for that atmosphere.", "domain": "chemistry", "round": 3} +{"url": "https://www.ornl.gov/division/buildings-and-transportation-science/news", "date": "2023-03-27T04:02:08Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-14/segments/1679296946637.95/warc/CC-MAIN-20230327025922-20230327055922-00032.warc.gz", "language_score": 0.9179818034172058, "token_count": 375, "dump": "CC-MAIN-2023-14", "global_id": "webtext-fineweb__CC-MAIN-2023-14__0__197632744", "lang": "en", "text": "Scientists at ORNL developed a competitive, eco-friendly alternative made without harmful blowing agents.\nORNL is teaming with the National Energy Technology Laboratory to jointly explore a range of technology innovations for carbon management and strategies for economic development and sustainable energy transitions in the Appalachian region.\nScientists have long sought to better understand the “local structure” of materials, meaning the arrangement and activities of the neighboring particles around each atom.\nA tool developed by ORNL researchers gives building owners and equipment manufacturers and installers an easy way to calculate the cost savings of a heating and cooling system that utilizes geothermal energy and emits no carbon.\nOak Ridge National Laboratory will host three JUMP into STEM competition winners as building technologies interns in summer 2023.\nNatural gas furnaces not only heat your home, they also produce a lot of pollution. Even modern high-efficiency condensing furnaces produce significant amounts of corrosive acidic condensation and unhealthy levels of nitrogen oxides, carbon monoxide, hy\nOak Ridge National Laboratory researchers demonstrated that window shades with a cellular or honeycomb structure provide higher energy savings during winter compared to generic venetian blinds and can save millions of tons of carbon em\nThe U.S. Combustion Institute has recognized Oak Ridge National Laboratory fuel science researcher Derek Splitter with the Early Career Combustion Investigator Award, a biannual honor that highlights excellence in the combustion research community.\nA team led by the Department of Energy’s Oak Ridge National Laboratory has developed a utility-scale design and control system for a hybrid solar power plant that can operate with both direct and alternating current — providing more\nSeven scientists at the Department of Energy’s Oak Ridge National Laboratory have been named Battelle Distinguished Inventors, in recognition of their obtaining 14 or more patents during their careers at the lab.", "domain": "chemistry", "round": 3} +{"url": "https://digitalcommons.usf.edu/kip_articles/941/", "date": "2024-03-02T04:37:34Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707947475727.3/warc/CC-MAIN-20240302020802-20240302050802-00285.warc.gz", "language_score": 0.8936931490898132, "token_count": 462, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__143638751", "lang": "en", "text": "Chemical similarities among physically distinct spring types in a karst terrain\nDownload Full Text\nIn karst regions where correlations between physical characteristics of springs and temporal variations in spring water chemistry have been found, spring water chemistry has been used to infer physical attributes of karst systems. Possible correlations between chemical and physical characteristics of springs were tested in the Inner Bluegrass Karst Region of central Kentucky where previous dye-tracing studies have identified two physically distinct spring types: local high-level springs discharging from shallow flow paths and major low-level springs discharging from a deep integrated conduit system. Representative high-level and major springs were sampled over a 16-month period and analyzed for major dissolved components. Both spring types showed similar variations in temperature, calcium, magnesium, bicarbonate, and hardness. No systematic differences in ionic concentrations or in saturation indices with respect to calcite and dolomite were apparent between the two spring types. Chemical similarities between high-level and major springs during low flow are attributed to recharge of major springs by percolation and by high-level springs and to the occurrence of most chemical reactions near the recharge zone rather than in the deep conduit system. During high discharge, however, most recharge to the major springs is surface runoff which produces low ionic concentrations. Similarly low ionic concentrations in the high-level springs are thought to result from rapid flow through the soil-rock zone and short flow distances. These relationships indicate that spring water chemistry is not only a function of conduit size but also an indicator of recharge type and amount and flow path length. Differing flow path lengths to major and high-level springs counteract the effect of varying conduit size between the two spring types and result in similar ionic concentrations. These data indicate that spring water chemistry cannot be used to predict physical characteristics of karst aquifers in the Inner Bluegrass Region. The p\nChemical Similarities, Physically Distinct Spring Types, Karst Terrain\nJournal of Hydrology, Vol. 89, no. 3-4 (2003-03).\nScanlon, B. R. and Thrailkill, J., \"Chemical similarities among physically distinct spring types in a karst terrain\" (2003). KIP Articles. 941.", "domain": "chemistry", "round": 3} +{"url": "https://pubmed.ncbi.nlm.nih.gov/30131271/", "date": "2023-10-04T01:38:18Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233511284.37/warc/CC-MAIN-20231003224357-20231004014357-00357.warc.gz", "language_score": 0.9052793383598328, "token_count": 364, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__161031727", "lang": "en", "text": "Thioloxidoreductase HP0231 of Helicobacter pylori plays essential roles in gastric colonization and related gastric pathology. Comparative proteomics and analysis of complexes between HP0231 and its protein substrates suggested that several Hop proteins are its targets. HP0231 is a dimeric oxidoreductase that functions in an oxidizing Dsb (disulfide bonds) pathway of H. pylori. H. pylori HopQ possesses six cysteine residues, which generate three consecutive disulfide bridges. Comparison of the redox state of HopQ in wild-type cells to that in hp0231-mutated cells clearly indicated that HopQ is a substrate of HP0231. HopQ binds CEACAM1, 3, 5 and 6 (carcinoembryonic antigen-related cell adhesion molecules). This interaction enables T4SS-mediated translocation of CagA into host cells and induces host signaling. Site directed mutagenesis of HopQ (changing cysteine residues into serine) and analysis of the functioning of HopQ variants showed that HP0231 influences the delivery of CagA into host cells, in part through its impact on HopQ redox state. Introduction of a C382S mutation into HopQ significantly affects its reaction with CEACAM receptors, which disturbs T4SS functioning and CagA delivery. An additional effect of HP0231 on other adhesins and their redox state, resulting in their functional impairment, cannot be excluded.\nKeywords: CagA; HP0231; Helicobacter pylori; HopQ; Thioloxidoreductases.\nCopyright © 2018 The Authors. Published by Elsevier GmbH.. All rights reserved.", "domain": "chemistry", "round": 3} +{"url": "http://www.mdpi.com/2218-273X/1/1/48", "date": "2015-03-31T03:22:11Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2015-14/segments/1427131300280.0/warc/CC-MAIN-20150323172140-00043-ip-10-168-14-71.ec2.internal.warc.gz", "language_score": 0.8098565340042114, "token_count": 467, "dump": "CC-MAIN-2015-14", "global_id": "webtext-fineweb__CC-MAIN-2015-14__0__120963022", "lang": "en", "text": "Abstract: Glycosylation improves the solubility and stability of proteins, contributes to the structural integrity of protein functional sites, and mediates biomolecular recognition events involved in cell-cell communications and viral infections. The first step toward understanding the molecular mechanisms underlying these carbohydrate functionalities is a detailed characterization of glycan structures. Recently developed glycomic approaches have enabled comprehensive analyses of N-glycosylation profiles in a quantitative manner. However, there are only a few reports describing detailed O-glycosylation profiles primarily because of the lack of a widespread standard method to identify O-glycan structures. Here, we developed an HPLC mapping method for detailed identification of O-glycans including neutral, sialylated, and sulfated oligosaccharides. Furthermore, using this method, we were able to quantitatively identify isomeric products from an in vitro reaction catalyzed by N-acetylglucosamine-6O-sulfotransferases and obtain O-glycosylation profiles of serum IgA as a model glycoprotein.\nThis is an open access article distributed under the\nCreative Commons Attribution License which permits unrestricted use, distribution,\nand reproduction in any medium, provided the original work is properly cited.\nExport to BibTeX\nMDPI and ACS Style\nYagi, H.; Ohno, E.; Kondo, S.; Yoshida, A.; Kato, K. Development and Application of Multidimensional HPLC Mapping Method for O-linked Oligosaccharides. Biomolecules 2011, 1, 48-62.\nYagi H, Ohno E, Kondo S, Yoshida A, Kato K. Development and Application of Multidimensional HPLC Mapping Method for O-linked Oligosaccharides. Biomolecules. 2011; 1(1):48-62.\nYagi, Hirokazu; Ohno, Erina; Kondo, Sachiko; Yoshida, Atsuhiro; Kato, Koichi. 2011. \"Development and Application of Multidimensional HPLC Mapping Method for O-linked Oligosaccharides.\" Biomolecules 1, no. 1: 48-62.", "domain": "chemistry", "round": 3} +{"url": "http://www.abmole.com/products/zcl278.html", "date": "2018-09-20T09:45:42Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-39/segments/1537267156423.25/warc/CC-MAIN-20180920081624-20180920101624-00454.warc.gz", "language_score": 0.7548047304153442, "token_count": 580, "dump": "CC-MAIN-2018-39", "global_id": "webtext-fineweb__CC-MAIN-2018-39__0__89747614", "lang": "en", "text": "ZCL278 is a selective Cdc42 GTPase inhibitor with Kd of 11.4 μM.\nACS Appl Mater Interfaces. 2017 Feb 22;9(7):5803-5816.\nTransmembrane Pathways and Mechanisms of Rod-like Paclitaxel Nanocrystals through MDCK Polarized Monolayer\nZCL278 purchased from AbMole\n|Source||ACS Appl Mater Interfaces (2017). Figure 9. ZCL 278 (Abmole BioScience. Houston, TX, USA)|\n|Cell Lines||MDCK cells|\n|Results||As shown in Figure 9, in the presence of ZCL 278, the transmembrane amount of PTX-NCs was reduced significantly, indicating that Cdc 42 participated in the regulation of the transport of PTX-NCs.|\n|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|\n|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|\n|Animal A Km|\nFor example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.\n|Solubility||DMSO 90 mg/mL|\nLB-100 is a water soluble protein phosphatase 2A (PP2A) inhibitor, with IC50 of 0.85 μM and 3.87 μM in BxPc-3 and Panc-1 cells.\nCompstatinis is a 13-residue cyclic peptide, binds to complement component C3 and inhibits complement activation with IC50 of 12 μM.\nAzaserine is an inhibitor of the rate limiting step of the hexosamine biosynthethic pathway (HBP) and an irreversible inhibitor of GGT1 (gamma-Glutamyltranspeptidase).\nTM6008 is a novel PHD inhibitor, which inhibited PHD and stabilized HIF activity in vitro.\nASP9521 is a novel, selective, orally bioavailable inhibitor of 17β-hydroxysteroid dehydrogenase type 5 (17βHSD5; AKR1C3).\nProducts are for research use only. Not for human use. We do not sell to patients.\n© Copyright 2010-2017 AbMole BioScience. All Rights Reserved.", "domain": "chemistry", "round": 3} +{"url": "https://www.research-collection.ethz.ch/handle/20.500.11850/452106?locale-attribute=en", "date": "2023-06-06T23:13:45Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-23/segments/1685224653183.5/warc/CC-MAIN-20230606214755-20230607004755-00452.warc.gz", "language_score": 0.9114844799041748, "token_count": 476, "dump": "CC-MAIN-2023-23", "global_id": "webtext-fineweb__CC-MAIN-2023-23__0__246841479", "lang": "en", "text": "Xylem sap phosphorus sampling using microdialysis—a non-destructive high sampling frequency method tested under laboratory and field conditions\n- Journal Article\nFor a better understanding of plant nutrition processes, it is important to study the flux of nutrients within plants. However, existing xylem sap sampling methods are typically destructive and do not allow for repeated, highly frequent measurements of nutrient concentration. In this paper, we present a novel use of microdialysis (MD) for characterizing xylem sap phosphate (PO43−) concentration as a possible alternative to destructive sampling. First, MD probes were tested under laboratory conditions in vitro, in a stirred solution test, and in vivo, using beech tree stem segments. Exponential decline in the relative recovery (RR) with an increasing MD pumping rate allows for determining an optimal sampling interval (i.e., the maximum amount of sample volume with the minimum required concentration). The RR changed only minimally, with a change in the simulated sap flow velocity during the in vivo stem segment test. This suggests that MD can be applied over a range of naturally occurring sap flow velocities. Differences in the ionic strength between the xylem sap and the perfusate pumped through the MD did not influence the RR. Then, MD was successfully applied in a 24 h field campaign in two beech trees of different ages and allowed for in situ assessments of the diurnal variation of PO43− concentration and (together with xylem flow measurements) flux variability in living trees. Both beech trees exhibited the same diurnal pattern in PO43− concentrations with higher concentrations in the younger tree. The xylem PO43− concentration measured with MD was in the same order of magnitude as that received through destructive sampling in the younger tree. The MD probes did not show a decline in RR after the field application. We showed that MD can be applied to capture the PO43− concentration dynamics in the xylem sap with bihourly resolution under field conditions. Show more\nJournal / seriesTree Physiology\nPages / Article No.\nPublisherOxford University Press\nSubjectDiurnal nutrition variability; In situ measurement; Microdialysis; Phosphorus; Xylem sap\nMoreShow all metadata", "domain": "chemistry", "round": 3} +{"url": "https://www.omicsonline.org/brazil/metachromatic-leukodystrophy-peer-reviewed-pdf-ppt-articles/", "date": "2020-01-19T00:07:03Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-05/segments/1579250593994.14/warc/CC-MAIN-20200118221909-20200119005909-00303.warc.gz", "language_score": 0.9148120284080505, "token_count": 337, "dump": "CC-MAIN-2020-05", "global_id": "webtext-fineweb__CC-MAIN-2020-05__0__101316640", "lang": "en", "text": "Metachromatic leukodystrophy is an inherited disorder characterized by the accumulation of fats called sulfatides in cells. This accumulation especially affects cells in the nervous system that produce myelin, the substance that insulates and protects nerves. Nerve cells covered by myelin make up a tissue called white matter.\nCauses: Metachromatic leukodystrophy (MLD) is usually caused by the lack of an important enzyme called arylsulfatase A. Because this enzyme is missing, chemicals called sulfatides build up in and damage the nervous system, kidneys, gallbladder, and other organs. In particular, the chemicals damage the protective sheaths that surround nerve cells. The disease is passed down through families (inherited).\nDiagnosis: Tests that may be done include: Blood or skin culture to look for low arylsulfatase A activity, Blood test to look for low arylsulfatase A enzyme levels, CT scan, DNA testing for the ARSA gene, MRI, Nerve biopsy, Nerve signalling studies, Urinalysis, Urine chemistry.\nMetachromatic leukodystrophy (MLD) is a lysosomal disorder caused by arylsulfatase A (ARSA) deficiency. It is classified into three forms according to the age of onset of symptoms (late infantile, juvenile, and adult). We carried out a cross-sectional and retrospective study, which aimed to determine the epidemiological, clinical, and biochemical profile of MLD patients from a national reference center for Inborn Errors of Metabolism in Brazil.", "domain": "chemistry", "round": 3} +{"url": "https://eurelco.org/2018/10/12/minerve-integrated-solution-to-long-term-landfill-management-problems/", "date": "2023-12-10T07:31:02Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679101282.74/warc/CC-MAIN-20231210060949-20231210090949-00779.warc.gz", "language_score": 0.8838295340538025, "token_count": 272, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__27538746", "lang": "en", "text": "The Walloon Region alone has more than 2,500 waste dumps, presenting with varying levels of contamination (SPAQUe – 2003). This analysis proves that there is an imperative need to find technically, environmentally, financially, and politically/legally realistic solutions to the problems of landfill sites. The MINERVE project has the aim of providing an integrated solution to long-term landfill management problems by developing a methodology broken down into three closely interconnected sections: characterisation of the landfill site, optimisation of the processes of landfill mineralisation and Excavation and treatment of mineralised waste by landfill mining.\nIn landfill mining, CTP is working to identify and validate the methods of recovery and treatment of waste with the aim of extracting usable materials. The trials carried out have shown that it is possible to recover typical fractions, such as:\nThe mineral fraction which could be used in cement-bound and other materials.\nThe fraction consisting of light plastics, which could be processed as replacement fuels.\nThe ferrous or non-ferrous metal fraction, usable as such.\nThe project is focusing on shortening the life cycle of waste eliminated in landfill sites via mineralisation optimisation (biochemical stabilisation) and maximisation of its further use (energy, materials) via landfill mining, thus reducing its overall environmental footprint and the associated risks of contamination.", "domain": "chemistry", "round": 3} +{"url": "http://www.sinap.cas.cn/xwzx/xsbg/201801/t20180115_4933025.html", "date": "2022-12-02T13:24:41Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-49/segments/1669446710902.80/warc/CC-MAIN-20221202114800-20221202144800-00396.warc.gz", "language_score": 0.6915292143821716, "token_count": 740, "dump": "CC-MAIN-2022-49", "global_id": "webtext-fineweb__CC-MAIN-2022-49__0__93109731", "lang": "en", "text": "学术报告：Engineering for Life Sciences:From supramolecular DNA-protein constructs to machine-assisted biotechnology\n报告题目：Engineering for Life Sciences:From supramolecular DNA-protein constructs to machine-assisted biotechnology\n报 告 人：Christof M. Niemeyer Karlsruhe Institute of Technology (KIT), Institute for Biological Interfaces (IBG-1)\nThe interaction of engineering and life sciences has a long history and one of the most important aspects of this fruitful collaboration regards the functional interfacing of technical systems with biological specimens. We are developing tailored biointerfaces by using `DNA surface technology’, taking advantage of DNA biochips that can be functionalized through specific Watson-Crick hybridization to facilitate the self-assembly of complex surface architectures bearing bioactive components. Essential approaches include surface chemistry, (bio)orthogonal coupling strategies for site-selective protein modification as well as concepts from ‘structural DNA nanotechnology’. These ‘bottom-up’ methods are complemented with ‘top-down’ fabrication processes, such as polymer pen lithography and microfluidics, to develop instrumentation and devices for the analysis of cellular systems and the establishment of biotechnological processes. I will present recent case studies from our work concerning the development of multiscale systems for biocatalytic cascade reactions and the investigation of cellular adhesion and signaling.\n• Niemeyer, C. M. (2017) Engineering for Life Sciences: A Fruitful Collaboration Enabled by Chemistry (Editorial). Angew Chem Int Ed Engl 56, 1934-1935.\n• Meyer, R., Giselbrecht, S., Rapp, B. E., Hirtz, M., Niemeyer, C. M. (2014) Advances in DNA-directed immobilization. Curr Opin Chem Biol 18C, 8-15\n• Angelin, A., Weigel, S., Garrecht, R., Meyer, R., Bauer, J., Kumar, R. K., Hirtz, M., Niemeyer, C. M. (2015) Multiscale Origami Structures as Interface for Cells. Angew Chem Int Ed Engl 54, 15813-15817\n• Rabe, K. S., Muller, J., Skoupi, M., Niemeyer, C. M. (2017) Cascades in Compartments: En Route to Machine-Assisted Biotechnology. Angew Chem Int Ed Engl 56, 13574-13589.\n• Peschke, T., Skoupi, M., Burgahn, T., Gallus, S., Ahmed, I., Rabe, K. S., Niemeyer, C. M. (2017) Self-Immobilizing Fusion Enzymes for Compartmentalized Biocatalysis. ACS Catalysis 7, 7866-7872", "domain": "chemistry", "round": 3} +{"url": "https://www.ijsmdo.org/articles/smdo/ref/2021/01/smdo210100/smdo210100.html", "date": "2023-12-06T23:48:03Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100626.1/warc/CC-MAIN-20231206230347-20231207020347-00694.warc.gz", "language_score": 0.6828084588050842, "token_count": 1720, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__94548255", "lang": "en", "text": "Int. J. Simul. Multidisci. Des. Optim.\nVolume 12, 2021\nAdvances in Modeling and Optimization of Manufacturing Processes\n|Number of page(s)||10|\n|Published online||29 October 2021|\n- A. García-Junceda, E. Macía, D. Garbiec, M. Serrano, J.M. Torralba, M. Campos, Effect of small variations in Zr content on the microstructure and properties of ferritic ODS steels consolidated by SPS, Metals 10, 348 (2020) [CrossRef] [Google Scholar]\n- N.Y. Iwata, A. Kimura, M. Fujiwara, N. Kawashima, Effect of milling on morphological and microstructural properties of powder particles for high-Cr oxide dispersion strengthened ferritic steels, J. Nucl. Mater. 367, 191–195 (2007) [CrossRef] [Google Scholar]\n- D.P. Doan, T.B. Tran, V.A. Nguyen, A.T. Phan, Microstructural evolution and some mechanical properties of nanosized yttrium oxide dispersion strengthened 13Cr steel, Adv. Natl. Sci.: Nanosci. Nanotechnol. 1, 035009 (2010) [CrossRef] [Google Scholar]\n- A. Meharwal, M. Kumar, S. Karak, J.D. Majumdar, I. Manna, High temperature oxidation study of nano-Y2O3 dispersed ferritic alloys synthesized by mechanical alloying and sintering, Metall. Mater. Trans. A 51, 5257–5267 (2020) [CrossRef] [Google Scholar]\n- S. Noh, B.K. Choi, C.H. Han, K.B. Kim, S.H. Kang, Y.B. Chun, T.K. Kim, Effect of Mechanical Alloying and Hot Consolidation Processes on the Microstructure and Mechanical Properties of ODS Steels (2013) [Google Scholar]\n- S. Cao, Z. Zhou, Microstructure and mechanical properties of an ODS ferritic steel with very low Cr content, J. Nucl. Mater. 551, 152971 (2021) [CrossRef] [Google Scholar]\n- R. Shashanka, D. Chaira, Optimization of milling parameters for the synthesis of nano-structured duplex and ferritic stainless steel powders by high energy planetary milling, Powder Technol. 278, 35–45 (2015) [CrossRef] [Google Scholar]\n- E. Macía, A. García-Junceda, M. Serrano, S. Hong, M. Campos, Effect of mechanical alloying on the microstructural evolution of a ferritic ODS steel with (Y-Ti-Al-Zr) addition processed by Spark Plasma Sintering (SPS), Nucl. Eng. Technol. (2021) [Google Scholar]\n- J. Harringa, B. Cook, B. Beaudry, Effects of vial shape on the rate of mechanical alloying in Si 80 Ge 20, J. Mater. Sci. 27, 801–804 (1992) [CrossRef] [Google Scholar]\n- M. Staltsov, I. Chernov, I. Bogachev, B. Kalin, E. Olevsky, L. Lebedeva, A. Nikitina, Optimization of mechanical alloying and spark-plasma sintering regimes to obtain ferrite-martensitic ODS steel, Nucl. Mater. Energy 9, 360–366 (2016) [CrossRef] [Google Scholar]\n- C. Suryanarayana, Does a disordered γ-TiAl phase exist in mechanically alloyed TiAl powders? Intermetallics 3, 153–160 (1995) [CrossRef] [Google Scholar]\n- C. Suryanarayana, Mechanical alloying and milling, Prog. Mater. Sci. 46, 1–184 (2001) [CrossRef] [Google Scholar]\n- C. Suryanarayana, E. Ivanov, R. Noufi, M. Contreras, J. 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Larsen, An assessment of milling time on the structure and properties of a nanostructured ferritic alloy (NFA), Metall. Mater. Trans. A 45, 5409–5418 (2014) [CrossRef] [Google Scholar]\n- M. Stanciulescu, P. Carlan, M. Mihalache, M. Abrudeanu, Optimisation of the mechanical alloying process for ODS ferritic steels for generation IV reactors application, Int. Nucl. Inf. Syst. 48, 236–242 (2016) [Google Scholar]\nCurrent usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.\nData correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.\nInitial download of the metrics may take a while.", "domain": "chemistry", "round": 3} +{"url": "https://www.alomone.com/p/anti-cavpan-1/ACC-004?b=35966", "date": "2023-12-07T16:07:19Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100677.45/warc/CC-MAIN-20231207153748-20231207183748-00461.warc.gz", "language_score": 0.8746932744979858, "token_count": 514, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__179273159", "lang": "en", "text": "- Peptide (C)DNFDYLTRDWSILGPHHLD, corresponding to amino acid residues 1506-1524 of rat CaV1.2 (Accession P22002). Intracellular, C-terminus region.\n- Western blot analysis of rat brain membranes:1. Anti-CaVpan α1 Antibody (#ACC-004), (1:200).\n2. Anti-CaVpan α1 Antibody, preincubated with Pan CaV α 1 Blocking Peptide (#BLP-CC004).\n- Rat basilar artery lysates (Murphy, K. et al. (2003) Mol. Pharmacol. 64, 640.).\n- Human placenta (1:300) (Bernucci, L. et al. (2006) Placenta 27, 1082.).\nCa2+ ions regulate many cellular processes such as secretion, proliferation, and apoptosis and they are also cofactors of many proteins.1,2 In neurons, Ca2+ entry through voltage-dependent Ca2+ (CaV) channels triggers neurotransmitter release. Fast synaptic transmission in the mammalian central nervous system (CNS) is mediated by several high voltage-dependent Ca2+ channels.3\nFive types of Ca2+ channels are expressed in the CNS: the L-type (CaV1), N-type (CaV2.2), P/Q-type (CaV2.1), R-type (CaV2.3), and the T-type (CaV3).4 Each CaV channel is a multimeric protein composed of a pore forming α1 subunit and the auxiliary β (CaVβ), α2δ and γ subunits. There are four known CaVβ subunits, in addition to four α2δ subunits and eight γ subunits.4\nSpecies reactivity key:\nAlomone Labs is pleased to offer an antibody directed against an epitope of rat CaV1.2 channel that is identical in all isoforms of CaV1 and CaV2. Anti-CaVpan α1 Antibody (#ACC-004) can be used in western blot, immunoprecipitation and immunohistochemistry applications. It has been designed to recognize the high voltage-gated calcium channels, CaV1 and CaV2 subfamily members, from human, rat and mouse samples.", "domain": "chemistry", "round": 3} +{"url": "https://experts.umn.edu/en/publications/sputtered-metal-oxide-broken-gap-junctions-for-tandem-solar-cells", "date": "2021-05-18T02:58:14Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-21/segments/1620243991650.73/warc/CC-MAIN-20210518002309-20210518032309-00513.warc.gz", "language_score": 0.8897435069084167, "token_count": 440, "dump": "CC-MAIN-2021-21", "global_id": "webtext-fineweb__CC-MAIN-2021-21__0__14628173", "lang": "en", "text": "Broken gap metal oxide tunnel junctions have been created for the first time by sputtering. Using a ceramic ZnO-SnO2 target and a reactively sputtered copper target we deposited ZnSnO3 and Cu2O for the n-type and p-type layers, respectively. The band edges and work functions of these materials are suitable for favorable alignment with the bands of copper indium gallium selenide (CIGS) for a tandem CIGS-based solar cell applications. Total junction specific resistivities under 1 Ω-cm2 have been achieved with Ohmic current-voltage (I-V) characteristics pointing to a broken gap band alignment. Low temperature I-V measurements confirmed the lack of traps at the interface despite other measurements pointing to an interface where bands overlap. Cu2O films contained copper inclusions, but they were shown, by conductive atomic force microscopy, not to be the dominant paths for conduction across the junction. Post-deposition annealing of junctions demonstrated thermal stability up to 300 °C, and the ability to improve conduction and influence device material's electron affinity by rapid thermal anneal (RTA). Optical transmission over 78% below a band gap of 2.4 eV was attained for as-deposited films.\nBibliographical noteFunding Information:\nThe authors acknowledge funding from a Department of Energy SunShot grant ( #DEEE0005319 ). The authors wish to acknowledge Wolfgang Körner (Fraunhofer Institute for Mechanics of Materials IWM) and Christian Elsässer (Institute for Applied Materials, Karlsruhe Institute of Technology) for the ZnSnO 3 density of states data that they provided. This work was conducted in Nanofabrication Center (NFC), University of Minnesota, an NSF-supported NNIN facility ( ECCS-0335765 ). Part of this work was carried out in the University of Minnesota Characterization Facility, a member of the NSF-funded Materials Research Facilities Network via the MRSEC program.\n- Solar energy\n- Transparent conducting oxide", "domain": "chemistry", "round": 3} +{"url": "https://asmedigitalcollection.asme.org/ICES/proceedings-abstract/ICES2003/36789/713/295963", "date": "2022-05-28T11:52:39Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-21/segments/1652663016373.86/warc/CC-MAIN-20220528093113-20220528123113-00137.warc.gz", "language_score": 0.8643964529037476, "token_count": 361, "dump": "CC-MAIN-2022-21", "global_id": "webtext-fineweb__CC-MAIN-2022-21__0__172807889", "lang": "en", "text": "This paper presents a thorough analysis of the exhaust gas aftertreatment systems of Gasoline Direct Injection (GDI) engines. The mechanism of the exhaust gas aftertreatment systems is investigated using chemical thermodynamics. The physical models of three-way-catalyst (TWC) and lean NOx trap (LNT) are presented. The objective is to propose an alternative approach for the identification of A/F ratio and oxygen concentration in the exhaust systems to substitute the costly oxygen sensors. A simple control scheme is included within the model identification and prediction results are compared with the testing data from the universal exhaust gas oxygen (UEGO) sensor and from the heated exhaust gas oxygen (HEGO) sensor. The oxygen storage effect has an essential impact on the LNT storage and purge operations, which will also affect the overall fuel economy of GDI engine systems. Its influence on the fuel economy has been estimated by numerical simulations, which is correspondent to the extra percentage of fuel consumption.\n- Internal Combustion Engine Division\nGDI Engine Exhaust Aftertreatment System Analysis and Oxygen Sensor Based Identification, Modeling and Control of Lean NOx Trap\n- Views Icon Views\n- Share Icon Share\n- Search Site\nYe, Z. \"GDI Engine Exhaust Aftertreatment System Analysis and Oxygen Sensor Based Identification, Modeling and Control of Lean NOx Trap.\" Proceedings of the ASME 2003 Internal Combustion Engine Division Spring Technical Conference. Design, Application, Performance and Emissions of Modern Internal Combustion Engine Systems and Components. Salzburg, Austria. May 11–14, 2003. pp. 713-719. ASME. https://doi.org/10.1115/ICES2003-0696\nDownload citation file:", "domain": "chemistry", "round": 3} +{"url": "https://antibodyplus.com/antibody-customer-review-for-sp1-polyclonal-antibody-stj95738/", "date": "2019-12-10T08:59:16Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-51/segments/1575540527010.70/warc/CC-MAIN-20191210070602-20191210094602-00015.warc.gz", "language_score": 0.8412166237831116, "token_count": 633, "dump": "CC-MAIN-2019-51", "global_id": "webtext-fineweb__CC-MAIN-2019-51__0__131092960", "lang": "en", "text": "No products in the cart.\nSP1 is a Zinc-finger transcription factor which binds with high affinity to GC-rich motifs to regulate genes which are involved in various processes like apoptosis, differentiation, growth and immune response. This protein is regulated by post translational modifications such as phosphorylation, sumoylation, proteolytic cleavage, glycosylation and acetylation. It is thought to play a role in the cellular response to DNA damage and implicated in chromatin remodeling.\n1. HOW DID OUR ANTIBODY PERFORM? ANTIBODY CUSTOMER REVIEW: SP1 Polyclonal Antibody (STJ95738)\n2. WHAT WAS USED? Primary antibody: SP1 PolyclonalAntibody (STJ95738) Provider: St John’s Laboratory Dilution ratio: 1:3000 Application: Immunohistochemistry Materials for validation: E12.5 telencephalon\n3. WHAT WAS THE PROTOCOL? Does not require antigen retrieval. Pre-treatment with heat citrate or EDTA buffer antigen retrieval reduces the signal to noise ratio. Treatment of materials: Tissue was fixed with 4% PFA in PBS for 2.5 hours at 4C, then incubated in 20% sucrose/PBS at 4C until tissue sunk (~2 hours). Thereafter, the tissue was embedded in cryomold solution (OCT) and flash frozen using cold isopentanol (cool with dry ice) Wash: 1X wash for 5 minutes with 0.1% Triton X-100 PBS. Blocking: 1 hour blocking with a solution containing 10% Donkey Serum, 1% BSA, 1M glycine, in 0.5% Triton X-100 PBS. Primary Ab Application: 48 hr incubation with primary antibody at 4C in a solution containing 1% BSA in 0.1% Triton X-100 PBS. Wash: 4X washes, 5 minutes each, with 0.1% Triton X-100 PBS. Secondary Ab Application: 1 hour incubation with 2nd antibody Alexa 488 (Invitrogen), 1:1500 dilution in 0.1% Triton X-100 PBS. Wash: 3X washes, 5 minutes each, with 0.1% Triton X-100 PBS.\n4. WHAT DID THE CUSTOMER THINK? Testing results provided by A. Molero of The Saul Korey Department of Neurology said that there was ¡°excellent signal to noise ratio, low background¡±.\n5. JOIN THE ANTIBODY VALIDATION PROJECT\n6. 1. Order any STJ9 catalogued product using this online form. 2. Test it in your laboratory using your preferred method. 3. Return a fully completed review form to receive rewards. ¡in 3 simple steps¡\n7. @StJohnsLabs http://www.slideshare.net/stjohnslabs", "domain": "chemistry", "round": 3} +{"url": "https://www.waynesautocenter.com/blog/does-the-brand-of-engine-oil-matter/", "date": "2023-12-10T20:44:55Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679102637.84/warc/CC-MAIN-20231210190744-20231210220744-00761.warc.gz", "language_score": 0.9479914307594299, "token_count": 299, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__154971381", "lang": "en", "text": "Are all car engine oils basically that same and, if so, does brand matter? Every oil you see on the store shelf meets the basic specifications for that weight oil (5W30, 10W30, etc) and is suitable for use in your car provided it is the correct weight as recommended by the vehicle manufacturer. That being said, a large part of the cost of engine oil is the additive package to the basic oil stock that will determine how resistant the oil is to thermal breakdown and how well it lubricates the engine. Premium oils tend to have better (more expensive) additive packages that enhance the lubricating and thermal resistance properties of the oil. This, in turn, means these oils tend to cost more than non premium oils.\nAt Wayne’s Automotive and Xpress Lube our standard oil is Castrol which is premium oil. It does cost more because of the additive package, but the better lubricating properties will most likely result in gas cost savings that more than offset the higher oil cost. Additionally, since Castrol is more resistant to thermal breakdown it provides better engine protection.\nSynthetic oils like Castrol Syntec provide even better protection against thermal breakdown meaning you can change the oil less frequently. If your car requires oil changes every 3000 miles, you can safely increase that interval to 5000 miles using Castrol Syntec. Syntec also provides better lubricating qualities that should improve your gas mileage as opposed to using non-synthetic oil.", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/ubxn6ubxd1-antibody-ab221167.html", "date": "2020-10-20T20:14:17Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-45/segments/1603107874135.2/warc/CC-MAIN-20201020192039-20201020222039-00257.warc.gz", "language_score": 0.7653407454490662, "token_count": 589, "dump": "CC-MAIN-2020-45", "global_id": "webtext-fineweb__CC-MAIN-2020-45__0__161843229", "lang": "en", "text": "Key features and details\n- Rabbit polyclonal to UBXN6/UBXD1\n- Suitable for: ICC/IF, WB\n- Reacts with: Human\n- Isotype: IgG\nProduct nameAnti-UBXN6/UBXD1 antibody\nSee all UBXN6/UBXD1 primary antibodies\nDescriptionRabbit polyclonal to UBXN6/UBXD1\nTested applicationsSuitable for: ICC/IF, WBmore details\nSpecies reactivityReacts with: Human\nPredicted to work with: Cow\n- HEK293 cells; RT4 and U251 MG cell lysates.\nThis product was previously labelled as UBXN6\nStorage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.\nStorage bufferpH: 7.20\nPreservative: 0.02% Sodium azide\nConstituents: 59% PBS, 40% BSA\nConcentration information loading...\nPurityImmunogen affinity purified\nOur Abpromise guarantee covers the use of ab221167 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\n|ICC/IF||Use a concentration of 0.25 - 2 µg/ml.\nFixation/Permeabilization: PFA/Triton X-100.\n|WB||Use a concentration of 0.04 - 0.4 µg/ml. Predicted molecular weight: 49 kDa.|\nFunctionActs in a complex with VCP and cooperates with USP7 in promoting MDM2 deubiquitination and stabilization. MDM2 stabilization leads to MDM2-dependent TP53 degradation.\nTissue specificityEnhanced expression in testis.\nSequence similaritiesContains 1 PUB (PUG) domain.\nContains 1 UBX domain.\nDomainThe UBX domain lacks key residues critical for VCP binding.\nCellular localizationCytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Localizes at the centrosome both in interphase and during mitosis.\n- Information by UniProt\n- UBX domain containing 1 antibody\n- UBX domain containing 2 antibody\n- UBX domain containing protein 1 antibody\nTo our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.\nab221167 has not yet been referenced specifically in any publications.", "domain": "chemistry", "round": 3} +{"url": "http://physics.njit.edu/people/sirenko.php", "date": "2016-07-27T19:08:58Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2016-30/segments/1469257827077.13/warc/CC-MAIN-20160723071027-00189-ip-10-185-27-174.ec2.internal.warc.gz", "language_score": 0.7147163152694702, "token_count": 540, "dump": "CC-MAIN-2016-30", "global_id": "webtext-fineweb__CC-MAIN-2016-30__0__46669726", "lang": "en", "text": "Materials science of magnetic and ferroelectric oxides, semiconductor nanostructures, QKD andPMD in transmission fibers, and characterization of monolithically-integrated GaN-basedoptoelectronic devices. Primary research interest is in the field of far-IR Transmission,Ellipsometry, and Raman Spectroscopy, Nanoscale High-Angular Resolution X-ray Diffraction, and X-ray Standing Waves. PI in the current beam-time proposals at the National Synchrotron Facilities NSLS, CHESS, and APS. Elected Member of the User Committee at CHESS (2004-2007).\nA. A. Sirenko, C. Bernhard, A. Golnik, Anna M. Clark, Jianhua Hao, Weidong Si, and X. X. Xi,\"Soft-mode hardening in SrTiO3 thin films\", Nature, 404, 373 (2000).Akimov, A. A. Sirenko, A. M. Clark, J.-H. Hao, and X. X. Xi, \"Electric field-induced soft-modehardening in SrTiO3 films\", Phys. Rev. Lett., 84, 4625 (2000).A. A. Sirenko, I. A. Akimov, J. R. Fox, A. M. Clark, Hong-Cheng Li, Weidong Si, and X. X. Xi,``Observation of the first-order Raman scattering in SrTiO3 thin films´´, Phys. Rev. Lett. 82, 4500(1999).S. Park, Y. Horibe, T. Asada, L. S. Wielunski, N. Lee, P. L. Bonanno, S. M. O’Malley, A. A.Sirenko, A. Kazimirov, M. Tanimura, T. Gustafsson, and S-W. Cheong, Epitaxial Nanorods with aCheckerboard Pattern in ZnMnGaO4 Films, Nano Letters (2008).A. A. Sirenko, S. M. O’Malley, and K. H. Ahn, S. Park, G. L. Carr, and S-W. Cheong, “Infraredactiveexcitations related to Ho3+ ligand-field splitting at the commensurate-incommensuratemagnetic phase transition in HoMn2O5”, Phys. Rev. B, (2008). cond-mat/0703255.", "domain": "chemistry", "round": 3} +{"url": "https://whitefog.com/sub_tags/america/", "date": "2023-06-03T18:52:17Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-23/segments/1685224649302.35/warc/CC-MAIN-20230603165228-20230603195228-00737.warc.gz", "language_score": 0.8064360618591309, "token_count": 413, "dump": "CC-MAIN-2023-23", "global_id": "webtext-fineweb__CC-MAIN-2023-23__0__108557806", "lang": "en", "text": "Showing all 26 results\nThermal Fogger – Thermal Fogging Machine SM600Engine: 25,4 Hp. Pulse Jet\nTank: 5,7 Liters (Stainless Steel)\nVehicle Mounted Thermal Fogger – Pulse Jet Machine SM700Engine: 112 Hp. Pulse Jet\nTank: 60 Liters (Stainless steel)\nElectric Portable ULV Cold Fogger Machine Manufacturer – MiniULVEngine: Electrical\nTank: 5 Lt. (Polyethylene)\nFumigation Machine Thermal Fogging – SM900Engine: 57,3 Hp. Pulse Jet\nTank: 100 Lt. (Stainless Steel)\namerica Thermal Foggers - america Cold Foggers\namerica Thermal Foggers\namerica Thermal Foggers Most thermal foggers have a spray nozzle, a heating chamber and a tank or reservoir. Inside the tank is a pump that carries the chemical to the heating chamber to be converted into mist. It normally takes the pre-heating process for 2 to 5 minutes. Once it is ready, you can simply unlock the trigger if any, or just pull the trigger. It should produce a misting fox reaching up to 15 feet. Since thermal foggers use heat to vaporize the fogging solution, it forms a thick cloud of fog that can be white or grey.\namerica Cold Foggers\namerica Cold Foggers These foggers are obviously the opposite of thermal fogger. Instead of using heat to vaporize the pesticide solution, it uses high-pressure of air to convert the solution into tiny particles. Most cold foggers are designed for water-based solutions but some may also work using both water and oil-based pesticides. Since most cold foggers run on electricity, it is advisable to have a power outlet near the fogging area or get an extension cord long enough to cover it. ULV foggers that use cold fogging techniques, on the other hand, produce a practically invisible fog.", "domain": "chemistry", "round": 3} +{"url": "http://metaglossary.com/meanings/346426/", "date": "2013-05-23T06:05:32Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2013-20/segments/1368702900179/warc/CC-MAIN-20130516111500-00047-ip-10-60-113-184.ec2.internal.warc.gz", "language_score": 0.8739238977432251, "token_count": 327, "dump": "CC-MAIN-2013-20", "global_id": "webtext-fineweb__CC-MAIN-2013-20__0__213681917", "lang": "en", "text": "A whitish, granular rock, consisting of feldspar and quartz intimately mixed; -- sometimes called whitestone, and leptynite.\nA course-grained, equigranular metamorphic rock, consisting of quartz, feldspar and the anhydrous ferromagnesium minerals pyroxene and garnet.\nA moderately fine grained metamorphic rock composed chiefly of quartz and feldspar, but commonly containing some garnet.\na high grade metamorphic rock with an equant texture (no foliation or lineation).\nmetamorphic rock with coarse interlocking grain and little or no foliation.\nA high-grade metamorphic rock that typically lacks hydrous minerals like micas and amphibole.\nA nonfoliated regional metamorphic rock with coarse interlocking grains, generally formed under conditions of relatively high pressure and temperature.\nan almost structureless quart-feldspar rock\ngranular metamorphic, catazonal rock, composed of less hydrous minerals: garnet, cordierite, hypersthene.\nA metamorphic rock, commonly granular in texture, which has cooled from temperatures above about 700° Centigrade\nGranulites are metamorphic rocks that have experienced high temperatures of metamorphism. They typically have a granular (granoblastic) texture -- that is, a texture comprised of similarly sized and shaped grains -- and hence the name granulite. They are of particular interest to geologists because many granulites represent samples of the deep continental crust.", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/ap-2-complex-subunit-alpha-1-antibody-epr75732b-ab170955.html", "date": "2019-11-21T08:33:16Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-47/segments/1573496670743.44/warc/CC-MAIN-20191121074016-20191121102016-00233.warc.gz", "language_score": 0.8047288656234741, "token_count": 1069, "dump": "CC-MAIN-2019-47", "global_id": "webtext-fineweb__CC-MAIN-2019-47__0__68953359", "lang": "en", "text": "Product nameAnti-AP-2 complex subunit alpha-1 antibody [EPR7573(2)(B)]\nSee all AP-2 complex subunit alpha-1 primary antibodies\nDescriptionRabbit monoclonal [EPR7573(2)(B)] to AP-2 complex subunit alpha-1\nTested applicationsSuitable for: WBmore details\nUnsuitable for: Flow Cyt,ICC/IF,IHC-P or IP\nSpecies reactivityReacts with: Mouse, Rat, Human\nwithin Human AP-2 complex subunit alpha-1 aa 950 to the C-terminus. The exact sequence is proprietary.\nDatabase link: O95782\n- HeLa, A431, 293T and HepG2 whole cell lysate (ab7900).\nStorage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.\nStorage bufferPreservative: 0.01% Sodium azide\nConstituents: 9% PBS, 40% Glycerol, 0.05% BSA, 50% Tissue culture supernatant\nPurityTissue culture supernatant\nOur Abpromise guarantee covers the use of ab170955 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\n|WB||1/1000 - 1/10000. Predicted molecular weight: 108 kDa.|\nFunctionComponent of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif.\nTissue specificityIsoform A expressed in forebrain, skeletal muscle, spinal cord, cerebellum, salivary gland, heart and colon. Isoform B is widely expressed in tissues and also in breast cancer and in prostate carcinoma cells.\nSequence similaritiesBelongs to the adaptor complexes large subunit family.\nCellular localizationCell membrane. Membrane > coated pit. AP-2 appears to be excluded from internalizing CCVs and to disengage from sites of endocytosis seconds before internalization of the nascent CCV.\n- Information by UniProt\n- 100 kDa coated vesicle protein A antibody\n- Adapter-related protein complex 2 alpha-1 subunit antibody\n- adapter-related protein complex 2 subunit alpha-1 antibody\nAll lanes : Anti-AP-2 complex subunit alpha-1 antibody [EPR7573(2)(B)] (ab170955) at 1/1000 dilution\nLane 1 : HeLa cell lysate\nLane 2 : A431 cell lysate\nLane 3 : 293T cell lysate\nLane 4 : HepG2 cell lysate\nLysates/proteins at 10 µg per lane.\nAll lanes : Goat anti-rabbit HRP at 1/2000 dilution\nDeveloped using the ECL technique.\nPredicted band size: 108 kDa\nab170955 has not yet been referenced specifically in any publications.", "domain": "chemistry", "round": 3} +{"url": "https://www.genetex.com/Product/Detail/POLR2E-antibody/GTX54591", "date": "2019-02-23T20:05:54Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-09/segments/1550249530087.75/warc/CC-MAIN-20190223183059-20190223205059-00582.warc.gz", "language_score": 0.8385412096977234, "token_count": 309, "dump": "CC-MAIN-2019-09", "global_id": "webtext-fineweb__CC-MAIN-2019-09__0__147672817", "lang": "en", "text": "PBS pH7.3, 0.02% sodium azide, 50% glycerol.\nStore as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.\nRecombinant funsion protein containing a sequence corresponding to amino acids 1-210 of human POLR2E (NP_002686.2).\nPurified by affinity chromatography\nFor laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.\nRna Polymerase Ii Subunit E,Rpabc1,Rpb5,Xap4,Hrpb25,Hsrpb5,Polr2E\nThis gene encodes the fifth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit is shared by the other two DNA-directed RNA polymerases and is present in two-fold molar excess over the other polymerase subunits. An interaction between this subunit and a hepatitis virus transactivating protein has been demonstrated, suggesting that interaction between transcriptional activators and the polymerase can occur through this subunit. A pseudogene is located on chromosome 11. [provided by RefSeq, Jul 2008]", "domain": "chemistry", "round": 3} +{"url": "https://pharmpk.com/PK08/PK2008345.html", "date": "2021-04-15T02:23:43Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-17/segments/1618038082988.39/warc/CC-MAIN-20210415005811-20210415035811-00133.warc.gz", "language_score": 0.8634498119354248, "token_count": 408, "dump": "CC-MAIN-2021-17", "global_id": "webtext-fineweb__CC-MAIN-2021-17__0__43230739", "lang": "en", "text": "Back to the Top\nCan someone please tell me whether we can infuse 100% PEG400 in monkeys.\nIf yes then how long should you take to infuse 2mL of PEG400 solution\nCan the monkeys tolerate it?\nAmit Shah, Ph.D.\nSr. Research Scientist\nFrontage Laboratories, Inc.\n75 E Uwchlan Ave, Suite 126\nExton, PA 19341\nBack to the Top\nSummary: Several antiepileptic drugs, such as carbamazepine and\nclonazepam, have low bioavailability in solid form and are insoluble\nin an aqueous solution. Alcohol solvents are often employed as\nvehicles when these drugs are studied in animal models. Secondary and\nparticularly tertiary alcohols are suspected of some anticonvulsant\nactivity. The present research evaluated the possibility that\npolyethylene glycol 400 (PEG 400) might be efficacious, toxic, or\nboth. Monkeys (N = 11) rendered epileptic by aluminum-hydroxide were\nadministered PEG 400 by constant rate (1 ml/hr) intravenous infusion\nfor 3-4 weeks, preceded and followed by several weeks of baseline. At\na concentration of 60%, PEG 400 significantly reduced seizure\nfrequency, but also exhibited severe side effects. These findings\nsuggest that experimental testing of anticonvulsants may be\ncompromised when this or similar solvents are used chronically for\n[this link didn't work for me - maybe it requires a log-in - db]\nWant to post a follow-up message on this topic?\nIf this link does not work with your browser send a follow-up message to PharmPK@boomer.org with \"PEG400 in monkeys\" as the subject\nSupport PharmPK by using the\nCopyright 1995-2011 David W. A. Bourne (firstname.lastname@example.org)", "domain": "chemistry", "round": 3} +{"url": "https://www.dry-air.co.uk/applications1/classic-car-storage-humidity-control", "date": "2022-06-25T16:16:10Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-27/segments/1656103036077.8/warc/CC-MAIN-20220625160220-20220625190220-00046.warc.gz", "language_score": 0.9229632019996643, "token_count": 255, "dump": "CC-MAIN-2022-27", "global_id": "webtext-fineweb__CC-MAIN-2022-27__0__148828223", "lang": "en", "text": "Keeping humidity levels at below 50% is vital in minimising corrosion of metal components on your car during storage. The most cost-effective solution to maintaining optimal conditions in your storage space is the installation of a desiccant dehumidifier. Unlike DX (condensation type) dehumidifiers, desiccant dehumidifiers, provide year round accurate humidity control against prevailing conditions even at lower temperatures where DX systems are unable to perform. As desiccant can operate effectively at low temperatures this also removes the need to heat the space other than for frost protection purposes. By controlling humidity against prevailing temperatures it ensures humidity levels also do not drop too low. The importance being too low a relative humidity, can lead to materials such as wood leather and natural rubber to dry out in winter months.\nFor several years the Swedish Corrosion Institute has been testing and observing cars, to identify which parts of the body suffer the most from corrosion. Tests revealed that the following elements are mostly exposed to corrosion: cross bars, stands, various supports (which are under load) and brackets of springs, wing spars, doors, bottom of the car, niches of headlights, fenders and bumpers.\nAlmost all major parts of the car are exposed to corrosion!", "domain": "chemistry", "round": 3} +{"url": "http://ivpaperjlps.a3maal.me/plant-hormones-essay.html", "date": "2018-05-26T13:39:47Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-22/segments/1526794867417.75/warc/CC-MAIN-20180526131802-20180526151802-00515.warc.gz", "language_score": 0.8887678980827332, "token_count": 553, "dump": "CC-MAIN-2018-22", "global_id": "webtext-fineweb__CC-MAIN-2018-22__0__61211247", "lang": "en", "text": "Download thesis statement on plant growth hormone lab report in our database or order an original thesis paper that will be written by one of our staff writers and. Answering the essay short answer exam question answering the essay/short answer it is usually the behavior of several plant hormones and. Plant hormone introduction plant hormones are signal molecules produced within the plant, and occur in extremely low concentrations hormones regulate. Essay questions 61 identify three types of plant hormones their functions and from biol 1408 at sam houston state university. Botany term papers (paper 1453) on plant hormones in agriculture: the role of hormones in plants the majority of people know that hormones play a vital and important. Click here click here click here click here click here if you need high-quality papers done quickly and with zero traces of plagiarism, papercoach is the.\nRead plant hormones - an overview of there functions free essay and over 88,000 other research documents plant hormones - an overview of there functions plant. Plant tissue culture plays important roles in agriculture field by improving the production and quality of crops using recombinant dna technology the mechanisms and. This trend is due to the auxins in the plant, hormones that promote growth when a seed is placed sideways, unnaturally, the auxins in the plant stimulate growth in.\nOrganogenesis is the process of forming a specific organ from non-specific mass of meristem or parenchyma cell known as callus in this experiment, auxin. A summary of plant hormones in 's plants: essential processes learn exactly what happened in this chapter, scene, or section of plants: essential processes and what. Free essay: auxins usually affect other processes in addition to cell elongation of stem cells but this characteristic is considered critical of all auxins.\nRelated posts: plant hormones and induction of organogenesis in vitro plant hormones and induction biology essay bollavaram varun plant tissue culture lab biology. Plant hormones are organic chemicals, and are usually referred to as ‘growth substances’ essays tropisms and plant hormones making use of plant hormones. Science essays: plant hormones: an overview of there functions. 250000 free plant hormones papers & plant hormones essays at #1 essays bank since 1998 biggest and the best essays bank plant hormones essays, plant hormones.\nRead this science research paper and over 88,000 other research documents plant hormones plant hormones are specialized chemical substances produced by plants they. Create your citations, reference lists and bibliographies automatically using the apa, mla, chicago, or harvard referencing styles it's fast and free. Plant hormones can be utilized in the commercial agriculture of important crops such as grapes, pineapple, watermelons and strawberries in the production of grapes.", "domain": "chemistry", "round": 3} +{"url": "http://www.moca-09.org/2022/09/05/moreover-antibodies-recognizing-comparable-epitopes-to-the-12-representative-mabs-existed-in-human-sera-after-hev-vaccination-suggesting-that-all-6-of-the-antigenic-sites-recognized-by-the/", "date": "2022-10-03T13:44:09Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-40/segments/1664030337421.33/warc/CC-MAIN-20221003133425-20221003163425-00277.warc.gz", "language_score": 0.9584881663322449, "token_count": 1209, "dump": "CC-MAIN-2022-40", "global_id": "webtext-fineweb__CC-MAIN-2022-40__0__61020189", "lang": "en", "text": "Moreover, antibodies recognizing comparable epitopes to the 12 representative mAbs existed in human sera after HEV vaccination, suggesting that all 6 of the antigenic sites recognized by the 12 representative mAbs participated in the formation of strong immune dominant epitopes around the E2s domain name. into 6 impartial groups, suggesting the presence of at least 6 epitopes. Twelve representative mAbs covering the six groups were selected as a tool box to further map functional antigenic sites around the E2s domain. By combining functional and location information of the 12 representative mAbs, this study provided a complete picture of potential neutralizing epitope regions and immune-dominant determinants on E2s domain name. One epitope region is located on top of the E2s domain name close to the monomer interface; the other is located around the monomer side of the E2s dimer round the groove zone. Besides, two non-neutralizing epitopes were also recognized on E2s domain name that did not stimulate neutralizing antibodies. Our results help further the understanding of protective mechanisms induced by the HEV vaccine. Furthermore, the tool box with 12 representative mAbs will be useful for studying the HEV contamination process. ER2566 strain (Invitrogen). The transformant was cultured in LB medium at 37 C for 4 h and then incubated for an additional 4 h in the presence of 0.2 mm isopropyl thio–d-galactoside. The cells were lysed by sonication in the presence of 2% Triton X-100. The sonicate was allowed to stand at 4 C for 30 min and then centrifuged at 12,000 rpm for 10 min. Then, the precipitant was washed once with 0.2% Triton X-100 and twice with buffer I (200 mm Tris-HCl, pH 8.5, 5 mm EDTA, and 100 mm NaCl). Each wash was followed by centrifugation at 12,000 rpm for 10 min. The pellet was resuspended in 4 m urea buffer (200 mm Tris-HCl, Rabbit Polyclonal to DNAI2 pH 8.5, 5 mm EDTA, 100 mm NaCl, and 4 m urea), allowed to stand for 30 min at room temperature, and centrifuged at 12,000 rpm for 10 min. The supernatant was dialyzed against PBS (pH 7.4) overnight and centrifuged at 12,000 rpm for 10 min. Target proteins (p239 and mutants) were present in the supernatants. The proteins were then purified and characterized according to methods previously explained (36, 41). Antibodies mAbs were raised against p239 antigens using a standard murine mAb preparation protocol (37). Indirect ELISA An indirect enzyme-linked immunosorbent assay (ELISA) was developed to detect the reactivity of HEV antibodies, including mAbs and sera obtained from mice or humans. Briefly, microwell plates were coated at 37 C for 3 h with 100 l of each of the purified recombinant antigens at a concentration of 1 1 g/ml in carbonate-bicarbonate buffer (pH 9.6). The wells were blocked with 0.5% (w/v) casein in phosphate-buffered saline (PBS) at 37 C for 2 h, washed, and dried. Antibodies diluted in PBS were added to the plates and incubated at 37 C for 30 min. After 5 rinses, HRP-conjugated anti-mouse or anti-human IgG Fab antibodies diluted 5000-fold in enzyme dilution buffer were added to DIPQUO detect the bound antibodies. After incubation at 37 C for 30 min, the plates were washed as explained above, and 100 l of tetramethylbenzidine substrate answer was added to the wells. The reaction was stopped DIPQUO by adding 50 l of 2 m H2SO4 after incubation at 37 C for 15 min, and the absorbance was measured at 450 nm with a reference wavelength of 620 nm. Western Blot The recombinant p239 proteins with or without boiling were loaded onto SDS-PAGE gel, respectively, and subsequently electroblotted onto nitrocellulose membrane (Whatman). The blot were blocked and reacted with DIPQUO mAbs according to methods previously explained (37). Immune Capture Assay The plates were coated with 300 l of mAbs (0.3 g/ml) diluted in 20 mm phosphate buffer (16.2 mm Na2HPO4, 3.8 mm NaH2PO4, pH 7.4) at 37 C for 2 h. Then, the plates were washed once with PBST (PBS with 0.05% Tween 20). The plates were subsequently incubated with 350 l of blocking reagent (PBS made DIPQUO up of 2% BSA) at 37 C for 2 h and washed. A total of 200 l of HEV suspension was added to the antibody-coated wells and incubated at 37 C for 2 h. The wells were rinsed five occasions. Then, 200 l of TRIzol was added into each well and incubated at 4 C for 10 min. HEV RNA was extracted, and the viral RNA titers captured DIPQUO by the mAbs were determined with a real-time reverse transcription (RT)-PCR assay. Real-time PCR HEV RNA was purified from 50 l of sample.\nMoreover, antibodies recognizing comparable epitopes to the 12 representative mAbs existed in human sera after HEV vaccination, suggesting that all 6 of the antigenic sites recognized by the 12 representative mAbs participated in the formation of strong immune dominant epitopes around the E2s domain name", "domain": "chemistry", "round": 3} +{"url": "https://motoroilinfo.com/amsoil-products/transmission-fluid/automatic/orignal-equipment-synthetic-autmoatic-transmission-fluid-oe/", "date": "2021-10-24T13:42:51Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-43/segments/1634323585997.77/warc/CC-MAIN-20211024111905-20211024141905-00559.warc.gz", "language_score": 0.8930520415306091, "token_count": 575, "dump": "CC-MAIN-2021-43", "global_id": "webtext-fineweb__CC-MAIN-2021-43__0__238994791", "lang": "en", "text": "Modern automatic transmissions are more complicated than their predecessors. Today’s designs feature more gears, clutch packs and narrow oil passageways that require a steady supply of high-quality fluid. Without it, wear and sludge formation can lead to reduced performance and even failure, requiring thousands of dollars in repairs. Amsoil OE Synthetic Automatic Transmission Fluid provides passenger-car/light-truck transmissions excellent wear protection, sludge resistance and extreme temperature performance throughout original equipment manufacturer (OEM)-recommended drain intervals.\nAmsoil OE Synthetic ATF is durable. In normal and severe service, it resists wear to the transmission’s valve body, gears, clutch plates and other vital parts, helping today’s complex and demanding transmissions achieve long life.\nPackage Sizes (OTL):\nIn elevated heat, Amsoil OE Synthetic ATF’s thermally stable formulation guards against the harmful effects of thermal breakdown. It resists the formation of varnish that can stick valves, threatening transmission performance and life. OE Synthetic ATF also resists heat-related evaporation and viscosity loss to help components stay clean and remain protected.\nAmsoil OE Synthetic ATF remains fluid in sub-zero temperatures. It resists thickening and flows quickly for fast, reliable shifts during cold starts. Its excellent low-temperature fluidity also maximizes fuel efficiency.\nFormulated with seal conditioners, Amsoil OE Synthetic ATF helps prevent seals and gaskets from drying out and cracking, reducing the risk of fluid leaks.\nAmsoil OE Synthetic ATF is formulated with friction modifiers that promote fast, smooth clutch engagement. As a result, drivers experience fast shift response and torque transfer for maximum drivability.\nTypical Technical Properties\nAMSOIL OE Multi-Vehicle Synthetic Automatic Transmission Fluid is recommended for transmissions and other applications that require any of the following specifications:\nNote: Not for use with CVT or Ford Type F applications.\nAMSOIL warrants the use of this product for Chrysler ATF+4® applications above -38°F. Product does not meet the cold temperature requirement of ATF+4 at -40°F. For warranty information, visit www.amsoil.com/warranty.aspx.\nAMSOIL OE Fuel-Efficient Synthetic Automatic Transmission Fluid is recommended for transmissions and other applications that require any of the following specifications:\nNote: Not for use with CVT applications.\nAMSOIL OE Synthetic Automatic Transmission Fluid should be changed according to your vehicle manufacturer’s recommendations.\nAMSOIL products are backed by a Limited Liability Warranty. For complete information visit www.amsoil.com/warranty.aspx.", "domain": "chemistry", "round": 3} +{"url": "https://www.qmul.ac.uk/sbbs/research/research-themes/structural-biology/", "date": "2023-09-28T11:57:07Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233510387.77/warc/CC-MAIN-20230928095004-20230928125004-00177.warc.gz", "language_score": 0.7236959934234619, "token_count": 1378, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__133171985", "lang": "en", "text": "Our research involves determining the shape, structure and dynamics of proteins and macromolecular machines to elucidate how they achieve their remarkable activities in the cell with a focus on a number of biological processes including: the conversion of light to chemical energy, bacterial pathogenesis, Alzheimer’s disease, cardiovascular disease and cancer.\nIn our studies we use integrated computational, biochemical and structural methods including X-ray crystallography, NMR spectroscopy and Cryo-electron microscopy in addition to spectroscopic and thermodynamic techniques. We study both soluble and membrane proteins and large macromolecular complexes.\nOur overarching goal is to understand the atomic and molecular basis of biological processes in terms of the architecture, assembly, dynamics and interactions that shape life at the cellular level. We are also interested in synthetic biology, where life processes are harnessed for improving and greening industrial transformations to bring about improvements in the quality of life.\nOur work underpins grand challenges in healthy ageing, antimicrobial resistance, energy, and synthetic biology where we target the macromolecular assemblies for therapeutic interventions or industrial biotechnology applications.\nX-ray, Crystallography, Electron microscopy, Protein-protein interaction, Ribonucleoprotein complex, Gene regulation\nStructure-function, Polypeptide toxins, Bioinformatics, 2struc, PCDDB, SRCD spectroscopy, Circular dichroism\nMain, Dr Ewan\nBiochemistry, Molecular biophysics, Repeat proteins, Protein folding\nHead of School and Professor of Structural Biology\nStructural biology, Protein crystallography, Synthetic biology, Enzymes, Cobalamin, Biosynthesis, Bacterial microcompartments\nUbiquitin, Host-pathogen interaction, Anti-microbial resistance, Structural biology, Enzymology\nProtein misfolding, Neurodegeneration, Alzheimers, Prions, Spectroscopy, Biochemistry\nOur research receives financial support from:\nOur studentships are also supported by:\nSaha S, Matthews D, Bessant C (2018). High throughput discovery of protein variants using proteomics informed by transcriptomics. Nucleic Acids Research\nPearce O, Delaine-Smith R, Maniati E, Nichols S, Wang J, Böhm S, Rajeeve V, Ullah D, Chakravarty P, Jones R, Montfort A, Dowe T, Gribben J, Jones L, Kocher H, Serody J, Vincent B, Connelly J, Brenton J, Chelala C, Cutillas P, Lockley M, Bessant C, Knight M, Balkwill F (2018). Deconstruction of a Metastatic Tumor Microenvironment Reveals a Common Matrix Response in Human Cancers. Cancer Discovery\nTiberti M, Pandini A, Fraternali F, Fornili A (2018). In silico identification of rescue sites by double force scanning. Bioinformatics\nPerez-Riba A, Lowe A, Main E, Itzhaki L (2018). Context-Dependent Energetics of Loop Extensions in a Family of Tandem-Repeat Proteins. Biophysical Journal\nGu M, Bode D, Viles J (2018). Copper Redox Cycling Inhibits Aβ Fibre Formation and Promotes Fibre Fragmentation, while Generating a Dityrosine Aβ Dimer. Scientific Reports\nUddin I, Frank S, Warren M, Pickersgill R (2018). A Generic Self‐Assembly Process in Microcompartments and Synthetic Protein Nanotubes. Small\nLee M, Mantell J, Brown I, Fletcher J, Verkade P, Pickersgill R, Woolfson D, Frank S, Warren M (2018). De novo targeting to the cytoplasmic and luminal side of bacterial microcompartments. Nature Communications\nPluta P, Roversi P, Bernardo-Seisdedos G, Rojas A, Cooper J, Gu S, Pickersgill R, Millet O (2018). Structural basis of pyrrole polymerization in human porphobilinogen deaminase. Biochimica Biophysica Acta\nHarvey J, Itzhaki L, Main E (2018). Programmed Protein Self-Assembly Driven by Genetically Encoded Intein-Mediated Native Chemical Ligation. ACS Synthetic Biology\nBarritt J, Younan N, Viles J (2017). N‐Terminally Truncated Amyloid‐β(11–40/42) Cofibrillizes with its Full‐Length Counterpart: Implications for Alzheimer's Disease. Angewandte Chemie\nHashem S, Tiberti M, Fornili A (2017). Allosteric modulation of cardiac myosin dynamics by omecamtiv mecarbil. PLoS Computational Biology\nJanes R (2017). PDB2CD visualises dynamics within protein structures. European Biophysics Journal\nGua S, Shevchik V, Shaw R, Pickersgill R, Garnett J (2017). The role of intrinsic disorder and dynamics in the assembly and function of the type II secretion system. Biochimica Biophysica Acta – Proteins and Proteomics\nKliza K, Taumer C, Pinzuti I, Franz-Wachtel M, Kunzelmann S, Stieglitz B, Macek B, Husnjak K (2017). Internally tagged ubiquitin: a tool to identify linear polyubiquitin-modified proteins by mass spectrometry. Nature Methods\nNishimura T, Nagao R, Noguchi T, Nield J, Sato F, Ifuku K (2016). The N-terminal sequence of the extrinsic PsbP protein modulates the redox potential of Cyt b559 in photosystem II. Scientific Reports\nDove K, Stieglitz B, Duncan E, Rittinger K, Klevit R (2016). Molecular insights into RBR E3 ligase ubiquitin transfer mechanisms. EMBO Reports\nYang Y, Darbari V, Zhang N, Lu D, Glyde R, Wang YP, Winkelman J, Gourse R, Murakami K, Buck M, Zhang X (2015). Structures of the RNA polymerase-σ54 reveal new and conserved regulatory strategies. Science", "domain": "chemistry", "round": 3} +{"url": "https://open.bu.edu/handle/2144/13729", "date": "2019-01-22T10:37:54Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-04/segments/1547583835626.56/warc/CC-MAIN-20190122095409-20190122121409-00243.warc.gz", "language_score": 0.9136531949043274, "token_count": 576, "dump": "CC-MAIN-2019-04", "global_id": "webtext-fineweb__CC-MAIN-2019-04__0__107297426", "lang": "en", "text": "Inhibition of AMPK via phosphorylation at Ser485/491: multiple mechanisms of regulation\nCoughlan, Kimberly A.\nMetadataShow full item record\nAMP-activated protein kinase (AMPK) is an energy-sensing enzyme that is activated when cellular energy is low and causes muscle and other cells to increase glucose uptake and fat oxidation, diminish lipid synthesis, and alter expression of various genes. AMPK activity is diminished in animals with the metabolic syndrome, though the mechanisms causing this reduction are unknown. To examine nutrient-induced changes in AMPK activity over time and factors that may regulate it, we compared rat muscle incubated with high glucose (HG) (30min-2h) and muscle of glucose-infused rats (3-8h) with appropriate controls. In addition to diminished AMPK activity (measured by the SAMS peptide assay) and phosphorylation of its activation loop at Thr172, we observed increased muscle glycogen, phosphorylation of AMPK’s α1/α2 subunit at Ser485/491, and PP2A activity, and decreased SIRT1 expression, all of which have been shown to diminish AMPK activity. Dysregulation of one or more of these factors could contribute to pathophysiological changes leading to metabolic syndrome associated disorders. Since recent studies suggest phosphorylation at Ser485/491 may play an important role in AMPK inhibition, we sought to determine how phosphorylation of this site is regulated. We investigated whether insulin or diacylglycerol (DAG) signaling pathways may be involved, since both are increased in at least one of the HG models. Akt and Protein Kinase (PK)D1 phosphorylated AMPK at Ser485/491 and diminished its activity in C2C12 myotubes, downstream of insulin and the DAG-mimetic PMA, respectively. Additionally, p-AMPK Ser485/491 was increased in muscle and liver of fed versus fasted mice and liver of diabetic mice. Our results suggest that Akt- and PKD1-mediated inhibition of AMPK via Ser485/491 phosphorylation may inhibit energy-metabolizing processes, while favoring energy-storing processes. Our results highlight the fact that phosphorylation of Ser485/491 can inhibit AMPK activity independent of changes in p-AMPK Thr172, a measure which is often used as a readout of AMPK activity. We hypothesize that Akt-mediated inhibition of AMPK is an acute, physiological response to insulin, whereas PKD1-mediated inhibition may be associated with more chronic pathophysiological changes. Thus, PKD1 inhibition or prevention of Ser485/491 phosphorylation may represent new strategies for therapeutic AMPK activation as treatment for the metabolic syndrome.", "domain": "chemistry", "round": 3} +{"url": "http://www.labcompare.com/313-Liquid-Handling-Robotics-Automated-Systems/621-Freedom-EVOlyzer-Automated-ELISA-Processing-Robot/", "date": "2013-05-21T22:58:48Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2013-20/segments/1368700842908/warc/CC-MAIN-20130516104042-00086-ip-10-60-113-184.ec2.internal.warc.gz", "language_score": 0.8947891592979431, "token_count": 283, "dump": "CC-MAIN-2013-20", "global_id": "webtext-fineweb__CC-MAIN-2013-20__0__136736880", "lang": "en", "text": "The Freedom EVOlyzer is a dedicated platform for automating microplate-based ELISAs, delivering accurate and reliable results with high efficiency. The instrument was created to increase the productivity of your workflow, and can be adapted to the changing needs of today’s diagnostics laboratory.\nNo need to compromise\nThe Freedom EVOlyzer has been designed to suit many different laboratory demands – from small scale laboratories performing many assays to test low numbers of samples, to high throughput screening facilities that analyze thousands of samples using a limited range of assays. The flexible workstation automates all common ELISA steps, including sample distribution, sample predilution, reagent pipetting, incubation, plate washing, optical density reading and result generation, without compromising operator safety.\nFreedom EVOlyzer highlights are:\n- IVD-D 98/79/EC, Annex III compliant open system for ELISA processing\n- fully automated pipetting, incubating, washing and data reduction\n- barcode identification (samples, reagents, microplates)\n- increased throughput due to continuous loading, parallel sample pipetting and large plate storage capability\n- integrated user and process safety concept: grid control, liquid level control, door locks, status lamp, integrated maintenance, user management\n- wizard guided easy-to-use Freedom EVOlution™ Software, designed for touch screen operation", "domain": "chemistry", "round": 3} +{"url": "https://saemobilus.sae.org/content/2016-01-2277/", "date": "2024-02-29T22:09:37Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707947474853.43/warc/CC-MAIN-20240229202522-20240229232522-00601.warc.gz", "language_score": 0.9300341606140137, "token_count": 443, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__55558014", "lang": "en", "text": "This content is not included in your SAE MOBILUS subscription, or you are not logged in.\nEngine Oil Additive Impacts on Low Speed Pre-Ignition\nISSN: 1946-3952, e-ISSN: 1946-3960\nPublished October 17, 2016 by SAE International in United States\nCitation: Fletcher, K., Dingwell, L., Yang, K., Lam, W. et al., \"Engine Oil Additive Impacts on Low Speed Pre-Ignition,\" SAE Int. J. Fuels Lubr. 9(3):612-620, 2016, https://doi.org/10.4271/2016-01-2277.\nLow speed pre-ignition (LSPI) is an undesirable combustion phenomenon that limits the fuel economy, drivability, emissions and durability performance of modern turbocharged engines. Because of the potential to catastrophically damage an engine after only a single pre-ignition event, the ability to reduce LSPI frequency has grown in importance over the last several years. This is evident in the significant increase in industry publications. It became apparent that certain engine oil components impact the frequency of LSPI events when evaluated in engine tests, notably calcium detergent, molybdenum and phosphorus. However, a close examination of the impact of other formulation additives is lacking. A systematic evaluation of the impact of the detergent package, including single-metal and bimetal detergent systems, ashless and ash-containing additives has been undertaken using a GM 2.0L Ecotec engine installed on a conventional engine dynamometer test stand. Consistent with previous reports, the detergent system was found to have the largest impact on LSPI frequency. Furthermore, once a balanced detergent system was identified and its LSPI impact was minimized, the effect of other additives, ash-containing as well as ashless, became apparent. In order to develop a robust additive package that maintains performance in critical bench and engine tests while offering optimal LSPI protection, consideration must be given to the impact of all lubricant additives not simply the detergent type and treat rate.", "domain": "chemistry", "round": 3} +{"url": "https://academic.naver.com/article.naver?doc_id=64821701", "date": "2018-06-25T20:49:28Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-26/segments/1529267868876.81/warc/CC-MAIN-20180625185510-20180625205510-00464.warc.gz", "language_score": 0.8467534184455872, "token_count": 846, "dump": "CC-MAIN-2018-26", "global_id": "webtext-fineweb__CC-MAIN-2018-26__0__129144961", "lang": "en", "text": "Study of enzymatic degradation of microbial copolyesters consisting of 3-hydroxybutyrate and medium-chain-length 3-hydroxyalkanoates\n- Li Zhenguo, Lin Hao, Ishii Nariaki, Chen Guo-Qiang, Inoue Yoshio\n- Department of Biomolecular Engineering, Tokyo Institute of Technology, 4259-B-55 Nagatsuta, Midori-ku, Yokohama 226-8501, Japan, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China\n- Polymer Degradation And Stability SCI(E) SCOPUS\n- Elsevier in 2007\n- Cited Count\nEnzymatic degradation of poly(3-hydroxybutyrate- co-3-hydroxyalkanoates) (PHBA) biopolyester consisting of 3-hydroxybutyrate (HB) and 15 mol% medium-chain-length 3-hydroxyalkanoates (HA) was studied using a polyhydroxyalkanoates (PHA) depolymerase produced by Ralstonia pickettii T1. It was found that PHBA films did not lose their weight after 25 h of depolymerase treatment. In contrast, three commercially available PHAs including poly-3-hydroxybutyrate (PHB), poly(3-hydroxybutyrate–19 mol% 3-hydroxyvalerate) (PHBV) and poly(3-hydroxybutyrate–19 mol% 3-hydroxyhexanoate) (PHBHHx) lost 75%, 94% and 39% of their original weights. Slow degradation of PHBA was also confirmed by the absence of HA monomers, dimers or trimers as degradation products in their depolymerase solution compared with abundance of degradation products released by the other three PHAs under the same condition. Surface erosion of PHBA was only observed after 48 h of enzymatic treatment compared with those of PHB, PHBV and PHBHHx which already had obvious surface changes after 7.5 h of same treatment. Although the crystallinities of PHB, PHBV, PHBHHx and PHBA were in the order PHB > PHBV > PHBHHx > PHBA valued at 55.8%, 47.8%, 45.9% and 40.9%, respectively, the order of degradability was PHBV > PHB > PHBHHx > PHBA. It can be proposed that PHA enzymatic degradation using this depolymerase was structure related: longer side-chain PHA including PHBHHx and PHBA was less favorable for the depolymerase degradation, longer the side chain, less the biodegradation.\n1.Biotechnol Adv. Vol. 25. 148(2007) Suriyamongkol P. et al.\n2.Biomacromolecules. Vol. 1. 17(2000) Matsusaki H. et al.\n3.Expert Rev Med Dev. Vol. 3. 853(2006) Valappil S.P. et al.\n4.Biomaterials. Vol. 26. 6565(2005) Chen G.Q. et al.\n5.Macromol Biosci. Vol. 7. 174(2007) Zou X.H. et al.\n6.Bioresour Technol. Vol. 97. 1994(2006) Patnaik P.R.\n7.J Ferment Bioeng. Vol. 90. 266(2000) Jung Y.M. et al.\n8.Polym Degrad Stab. Vol. 80. 183(2003) Akiyama M. et al.\n9.Appl Microbiol Biotechnol. Vol. 57. 50(2001) Chen G.Q. et al.\n10.Biomacromolecules. Vol. 2. 142(2001) Matsumoto K. et al.", "domain": "chemistry", "round": 3} +{"url": "https://www.compelo.com/packaging/news/eliminating-paper-machine-deposition/", "date": "2019-03-21T08:39:54Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-13/segments/1552912202506.45/warc/CC-MAIN-20190321072128-20190321094128-00442.warc.gz", "language_score": 0.9332762956619263, "token_count": 288, "dump": "CC-MAIN-2019-13", "global_id": "webtext-fineweb__CC-MAIN-2019-13__0__124189709", "lang": "en", "text": "KemFlite is a new concept developed by Kemira to reduce paper and board machine problems caused by deposits due to the agglomeration of hydrophobic particles. These typically originate from wood pitch, stickies or binders in coated broke and have previously been difficult to detect and control. Under certain conditions, they can agglomerate to a larger size and eventually deposit on paper machine wet-end surfaces, wires, felts and dryer cans.\nKemFlite is designed to manage the hydrophobic substances, particularly their size, before they form deposits. The concept combines tools including Kemira Flyto – a unique laboratory analysis to measure the particle size, quantity and hydrophobicity in samples taken from key points in the process – and Kemira AutoFlite, an on-line device that continuously provides similar information.\nFollowing a complete mill survey by Kemira’s application experts, a tailor-made deposit control programme can be implemented to manage the hydrophobic substances found in a mill’s process waters and eliminate machine deposition. It is claimed that the KemFlite concept has been proven in numerous mill cases, where it has improved machine runnability and reduced defects such as holes, spots, specks and hickeys in the final paper or board product.\nExternal weblinksConverting Today is not responsible for the content of external internet sites.Kemira", "domain": "chemistry", "round": 3} +{"url": "https://www.alfa.com/fr/catalog/H60207/", "date": "2017-06-27T00:14:20Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-26/segments/1498128320873.54/warc/CC-MAIN-20170626235612-20170627015612-00702.warc.gz", "language_score": 0.7557148337364197, "token_count": 330, "dump": "CC-MAIN-2017-26", "global_id": "webtext-fineweb__CC-MAIN-2017-26__0__140617794", "lang": "en", "text": "Benzyl chloromethyl ether is employed in the introduction of benzoyloxy- and hydroxymethyl groups.\nDane A. Goff.; Ralph N. HarrisIII.; Jeffrey C. Bottaro.; Clifford D. Bedford. Cleavage of methoxymethyl ethers with boron trichloride. A convenient, versatile preparation of chloromethyl ether derivatives. J. Org. Chem. 1986, 51 (24),4711-4714.\nArthur J. Hill.; DeWitt T. Keach. Some Ether-Substituted Derivatives Of Diethyl Malonate And Barbituric Acid.J. Am. Chem. Soc. 1926, 48 (1),257-262.\nMentions de danger (UE): H302-H331-H315-H318-H350-H335-H373\nHarmful if swallowed. Toxic if inhaled. Causes skin irritation. Causes serious eye damage. May cause cancer. May cause respiratory irritation. May cause damage to organs through prolonged or repeated exposure.\nMentions de prudence: P260-P201-P280g-P304+P340-P405-P501a\nDo not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. Wear protective gloves. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/polycystin-1pc1-antibody-c-terminal-ab223673.html", "date": "2020-10-24T03:37:59Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-45/segments/1603107881640.29/warc/CC-MAIN-20201024022853-20201024052853-00123.warc.gz", "language_score": 0.7729897499084473, "token_count": 694, "dump": "CC-MAIN-2020-45", "global_id": "webtext-fineweb__CC-MAIN-2020-45__0__113017562", "lang": "en", "text": "Key features and details\n- Goat polyclonal to Polycystin 1/PC1 - C-terminal\n- Suitable for: IHC-P\n- Reacts with: Human\n- Isotype: IgG\nProduct nameAnti-Polycystin 1/PC1 antibody - C-terminal\nSee all Polycystin 1/PC1 primary antibodies\nDescriptionGoat polyclonal to Polycystin 1/PC1 - C-terminal\nTested applicationsSuitable for: IHC-Pmore details\nSpecies reactivityReacts with: Human\n- IHC-P: Human kidney tissue.\nThis product was previously labelled as Polycystin 1\nStorage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.\nStorage bufferpH: 7.30\nPreservative: 0.02% Sodium azide\nConstituents: 0.5% BSA, Tris buffered saline\nConcentration information loading...\nPurityImmunogen affinity purified\nPurification notesab223673 was purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.\nOur Abpromise guarantee covers the use of ab223673 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\n|IHC-P||Use a concentration of 3 - 5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.|\nFunctionMay be an ion-channel regulator. PKD1 and PKD2 may function through a common signaling pathway that is necessary for normal tubulogenesis. Involved in adhesive protein-protein and protein-carbohydrate interactions.\nInvolvement in diseaseDefects in PKD1 are the cause of polycystic kidney disease autosomal dominant type 1 (ADPKD1) [MIM:173900]. ADPKD is characterized by progressive formation and enlargement of cysts in both kidneys, typically leading to end-stage renal disease in adult life. Cysts also occurs in the liver and other organs. Its prevalence is estimated at about 1/1000.\nSequence similaritiesBelongs to the polycystin family.\nContains 1 C-type lectin domain.\nContains 1 GPS domain.\nContains 1 LDL-receptor class A domain.\nContains 2 LRR (leucine-rich) repeats.\nContains 1 LRRCT domain.\nContains 1 LRRNT domain.\nContains 17 PKD domains.\nContains 1 PLAT domain.\nContains 1 REJ domain.\nContains 1 WSC domain.\nDomainThe LDL-receptor class A domain is atypical; the potential calcium-binding site is missing.\n- Information by UniProt\n- Autosomal dominant polycystic kidney disease 1 protein antibody\n- Autosomal dominant polycystic kidney disease protein 1 antibody\n- nPKC-D1 antibody\nab223673 has not yet been referenced specifically in any publications.", "domain": "chemistry", "round": 3} +{"url": "https://www.semanticscholar.org/topic/Polyvinyl-Alcohol-0.014-ML%2FML-%2F-Povidone-6-MG%2FML/10453027", "date": "2021-07-28T14:21:56Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-31/segments/1627046153729.44/warc/CC-MAIN-20210728123318-20210728153318-00553.warc.gz", "language_score": 0.8108798265457153, "token_count": 290, "dump": "CC-MAIN-2021-31", "global_id": "webtext-fineweb__CC-MAIN-2021-31__0__214529339", "lang": "en", "text": "Polyvinyl Alcohol 0.014 ML/ML / Povidone 6 MG/ML Ophthalmic Solution\nSemantic Scholar uses AI to extract papers important to this topic.\nUsing our previously reported observations, we derive some physical parameters of the moderately fast nova V2676 Ophiuchi 2012… Expand Purpose Fricke gel (FG) dosimeters are good candidates for 3D dose assessment in biological materials. Their effective atomic… Expand Almost general poly(vinyl alcohol) (PVA) films were prepared by the processing of a PVA solution. For the first time, a novel… Expand Antimicrobial electrospun poly(vinyl alcohol) (PVA) nanofibers were synthesized by impregnating benzyl triethylammonium chloride… Expand A major challenge in designing artificial photosynthetic systems is to find a suitable mimic of the highly oxidizing photoactive… Expand Aims. We study the inner sub-AU region of the circumstellar environment of the UX Ori-type star KK Oph with near-infrared VLTI… Expand 3D Continuum radiative transfer in complex dust configurations around young stellar objects and active nuclei II. 3D Structure of… Expand We observed a 17′×17′ region of the ρ Oph molecular cloud, using the ACIS-I array onboard the Chandra X-ray Observatory (CXO). A… Expand", "domain": "chemistry", "round": 3} +{"url": "https://p3.snf.ch/project-141913", "date": "2022-08-18T02:41:43Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882573145.32/warc/CC-MAIN-20220818003501-20220818033501-00173.warc.gz", "language_score": 0.760654628276825, "token_count": 1778, "dump": "CC-MAIN-2022-33", "global_id": "webtext-fineweb__CC-MAIN-2022-33__0__148325915", "lang": "en", "text": "ABC transporter; Saccharomyces cerevisiae; Trypanosoma brucei; Drug target; Lipid precursor; Xenopus laevis oocyte; Amino acid permease; Ion channel\nMathieu C, Macedo JP, Hürlimann D, Wirdnam C, Haindrich AC, Suter Grotemeyer M, Gonzalez-Salgado A, Schmidt RS, Inbar E, Mäser P, Bütikofer P, Zilberstein D, Rentsch D (2017), Arginine and lysine transporters are essential for Trypanosoma brucei, in PLoS One\n, 12, e0168775.\nRusso-Abrahão T, Koeller CM, Steinmann ME, Silva-Rito S, Marins-Lucena T, Alves-Bezerra M, Lima-Giarola NL, de-Paula IF, Gonzalez-Salgado A, Sigel E, Bütikofer P, Heise N, Gondim KC (2017), H+-dependent inorganic phosphate uptake in Trypanosoma brucei is influenced by myo-inositol transporter, in Meyer-Fernandes, JR\n, J Bioenerg Biomembr(49), 183.\nGottier P, Gonzalez-Salgado A, Menon AK, Liu YC, Acosta-Serrano A, Bütikofer P (2017), RFT1 Protein Affects Glycosylphosphatidylinositol (GPI) Anchor Glycosylation, in J Biol Chem\n, 292, 1103.\nSteinmann ME, Schmidt RS, Bütikofer P, Mäser P, Sigel E (2017), TbIRK is a signature sequence free potassium channel from Trypanosoma brucei locating to acidocalcisomes, in Scientific Reports\n, 7(1), 656.\nGoldman-Pinkovich A, Balno C, Strasser R, Zeituni-Molad M, Bendelak K, Rentsch D, Ephros M, Jardim A, Wiese M, Myler PJ, Zilberstein D (2016), An Arginine Deprivation Response Pathway Is Induced in Leishmania during Macrophage Invasion, in PLoS Pathogens\n, 12, e1005494.\nde Macêdo J (2015), An Atypical Mitochondrial Carrier That Mediates Drug Action in Trypanosoma brucei, in PLoS Pathogens\n, 11, e1004875.\nSerricchio M, Schmid AW, Steinmann ME, Sigel E, Rauch M, Julkowska D, Bonnefoy S, Fort C, Bastin P, Bütikofer P (2015), Flagellar membranes are rich in raft-forming phospholipids, in Biol Open\n, 14, 1143.\nSchlisselberg D, Mazarib E, Inbar E, Rentsch D, Myler PJ, Zilberstein D (2015), Size does matter: 18 amino acids at the N-terminal tip of an amino acid transporter in Leishmania determine substrate specificity, in Scientific Reports\n, 5, 16289.\nShameer S (2015), TrypanoCyc: a community-led biochemical pathways database for Trypanosoma brucei, in Nucleic Acids Res\n, 43, D637.\nGonzález-Salgado A (2015), Trypanosoma brucei Bloodstream Forms Depend upon Uptake of myo-Inositol for Golgi Complex Phosphatidylinositol Synthesis and Normal Cell Growth, in Eukaryot Cell\n, 14, 616.\nMathieu Christoph, Salgado Amaia González, Wirdnam Corina, Meier Stefan, Grotemeyer Marianne Suter, Inbar Ehud, Mäser Pascal, Zilberstein Dan, Sigel Erwin, Bütikofer Peter, Rentsch Doris (2014), Trypanosoma brucei eflornithine transporter AAT6 is a low-affinity low-selective transporter for neutral amino acids., in The Biochemical journal\n, 463(1), 9-18.\nInbar E, Schlisselberg D, Suter Grotemeyer M, Rentsch D, Zilberstein D (2013), A versatile proline/alanine transporter in the unicellular pathogen Leishmania donovani regulates amino acid homoeostasis and osmotic stress responses, in Biochem\n, 449, 555.\nMacêdo Juan P, Schmidt Remo S, Mäser Pascal, Rentsch Doris, Vial Henri J, Sigel Erwin, Bütikofer Peter (2013), Characterization of choline uptake in Trypanosoma brucei procyclic and bloodstream forms., in Molecular and biochemical parasitology\n, 190(1), 16-22.\nGreganova Eva, Steinmann Michael, Mäser Pascal, Fankhauser Niklaus (2013), In silico ionomics segregates parasitic from free-living eukaryotes., in Genome biology and evolution\n, 5(10), 1902-9.\nSteinmann M, A heteromeric potassium channel involved in the modulation of the plasma membrane potential is essential for the survival of African trypanosomes, in FASEB J\nTransporters are increasingly being recognized as key players in cell physiology and determinants of drug susceptibility. This is particularly the case for parasites, which - by definition - rely on import of nutrients from their hosts. In our ongoing Sinergia project on functional genomics of nutrient transporters in Trypanosoma brucei, we are investigating four selected groups of nutrient transporters which we believe to be of particular pharmacological interest in the sleeping sickness parasite: ion channels, amino acid transporters, ABC transporters, and transporters of lipid precursors. Substrate specificities and transport kinetics are being determined by expression in Saccharomyces cerevisiae and Xenopus laevis oocytes while the physiological role is studied by reverse genetics in T. brucei. This combination has proven very fruitful. By investigating transporters in an interdisciplinary way, we are validating them as drug targets or drug delivery systems. In the present research proposal we will further extend and deepen these analyses. Incorporating phylogenomic comparisons with fully sequenced trypanosomatid genomes and new developments in the field of T. brucei molecular genetics will allow us to understand the transporters in the context of their phylogeny, physiology and pharmacology.Essentiality of T. brucei nutrient transporters will be predicted in silico based on conserved orthology groups amongst trypanosomatids and imprints of negative selection in the coding regions. Essentiality prediction in vivo will be performed by a combination of genome-wide RNAi screens and high throughput sequencing. Thus nutrient transporters will be prioritized according to their predicted pharmacological and physiological importance. Heterologous expression in S. cerevisiae and X. laevis oocytes functionally characterizes the transporters and serves as a screening platform for inhibitors and toxic substrates of transporters that have been validated as essential in T. brucei bloodstream forms. The subcellular localization of transporters will be determined in trypanosomes, and lipidomics and metabolomics will be applied to study transport physiology and to de-orphanize transporters of unknown substrates. Finally, drug tests against bloodstream-form T. brucei in culture or in a mouse model will validate the identified inhibitors or toxic substrates and identify further leads. Integrated data management will be done on the KNIME (Konstanz Information Miner) platform.The proposed research will result in an increased understanding of the evolution of T. brucei transporters, their physiology in terms of nutrient acquisition and metabolism, and their pharmacological potential for chemotherapeutic strategies that exploit transporters as drug delivery systems or targets. New starting points for drug development against trypanosomatid parasites and potentially novel kinds of nutrient transporters will be discovered.", "domain": "chemistry", "round": 3} +{"url": "https://www.genetex.com/Product/Detail/RPB2-antibody/GTX64604", "date": "2023-06-06T01:40:45Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-23/segments/1685224652207.81/warc/CC-MAIN-20230606013819-20230606043819-00746.warc.gz", "language_score": 0.7636922597885132, "token_count": 353, "dump": "CC-MAIN-2023-23", "global_id": "webtext-fineweb__CC-MAIN-2023-23__0__171834546", "lang": "en", "text": "PBS pH7.3, 50% Glycerol\n0.02% Sodium azide\nStore as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.\nBatch dependent (Please refer to the vial label for the specific concentration.)\nRecombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human POLR2B (NP_000929.1).\nPurified by affinity chromatography\nFor laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.\nRNA polymerase II subunit B , POL2RB , RPB2 , hRPB140\nThis gene encodes the second largest subunit of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase that catalyzes the transcription of DNA into precursors of mRNA, snRNA and microRNA. This subunit and the largest subunit form opposite sides of the center cleft of Pol II. Deletion of the flap loop region of this subunit results in a decrease in the rate of transcriptional elongation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]", "domain": "chemistry", "round": 3} +{"url": "https://www.researchgate.net/publication/342401364_On_the_why's_and_how's_of_clay_minerals'_importance_in_life's_emergence", "date": "2023-12-08T17:25:17Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100762.64/warc/CC-MAIN-20231208144732-20231208174732-00856.warc.gz", "language_score": 0.8886566162109375, "token_count": 1228, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__250002342", "lang": "en", "text": "Layered double hydroxide (LDH) compounds are characterized by structures in which layers with a brucite-like structure carry a net positive charge, usually due to the partial substitution of trivalent octahedrally coordinated cations for divalent cations, giving a general layer formula [( M 1– x ²⁺ M ³⁺ x )(OH) 2 ] x + . This positive charge is balanced by anions which are intercalated between the layers. Intercalated molecular water typically provides hydrogen bonding between the brucite layers. In addition to synthetic compounds, some of which have significant industrial applications, more than 40 mineral species conform to this description. Hydrotalcite, Mg 6 Al 2 (OH) 16 [CO 3 ]·4H 2 O, as the longest-known example, is the archetype of this supergroup of minerals. We review the history, chemistry, crystal structure, polytypic variation and status of all hydrotalcite-supergroup species reported to date. The dominant divalent cations, M ²⁺ , that have been reported in hydrotalcite supergroup minerals are Mg, Ca, Mn, Fe, Ni, Cu and Zn; the dominant trivalent cations, M ³⁺ , are Al, Mn, Fe, Co and Ni. The most common intercalated anions are (CO3) 2– , (SO 4 ) 2– and Cl – ; and OH – , S 2– and [Sb(OH) 6 ]– have also been reported. Some species contain intercalated cationic or neutral complexes such as [Na(H 2 O) 6 ] ⁺ or [MgSO4]0. We define eight groups within the supergroup on the basis of a combination of criteria. These are (1) the hydrotalcite group, with M ²⁺ : M ³⁺ = 3:1 (layer spacing ∼7.8 Å); (2) the quintinite group, with M ²⁺ : M ³⁺ = 2:1 (layer spacing ∼7.8 Å); (3) the fougèrite group, with M ²⁺ = Fe ²⁺ , M ³⁺ = Fe ³⁺ in a range of ratios, and with O2– replacing OH– in the brucite module to maintain charge balance (layer spacing ∼7.8 Å); (4) the woodwardite group, with variable M ²⁺ : M ³⁺ and interlayer [SO4]2 –, leading to an expanded layer spacing of ∼8.9 Å; (5) the cualstibite group, with interlayer [Sb(OH)6]– and a layer spacing of ∼9.7 Å; (6) the glaucocerinite group, with interlayer [SO4]2– as in the woodwardite group, and with additional interlayer H2O molecules that further expand the layer spacing to ∼11 Å; (7) the wermlandite group, with a layer spacing of ∼11 Å, in which cationic complexes occur with anions between the brucite-like layers; and (8) the hydrocalumite group, with M ²⁺ = Ca ²⁺ and M ³⁺ = Al, which contains brucite-like layers in which the Ca:Al ratio is 2:1 and the large cation, Ca ²⁺ , is coordinated to a seventh ligand of 'interlayer' water.\nThe principal mineral status changes are as follows. (1) The names manasseite, sjögrenite and barbertonite are discredited; these minerals are the 2H polytypes of hydrotalcite, pyroaurite and stichtite, respectively. Cyanophyllite is discredited as it is the 1M polytype of cualstibite. (2) The mineral formerly described as fougèrite has been found to be an intimate intergrowth of two phases with distinct Fe ²⁺ :Fe ³⁺ ratios. The phase with Fe ²⁺ :Fe ³⁺ = 2:1 retains the name fougèrite; that with Fe ²⁺ :Fe ³⁺ = 1:2 is defined as the new species trébeurdenite. (3) The new minerals omsite (IMA2012-025), Ni2Fe ³⁺ (OH) 6 [Sb(OH) 6 ], and mössbauerite (IMA2012-049), Fe ³⁺ 6O 4 (OH) 8 [CO3]·3H 2 O, which are both in the hydrotalcite supergroup are included in the discussion. (4) Jamborite, carrboydite, zincaluminite, motukoreaite, natroglaucocerinite, brugnatellite and muskoxite are identified as questionable species which need further investigation in order to verify their structure and composition. (5) The ranges of compositions currently ascribed to motukoreaite and muskoxite may each represent more than one species. The same applies to the approved species hydrowoodwardite and hydrocalumite. (6) Several unnamed minerals have been reported which are likely to represent additional species within the supergroup.\nThis report has been approved by the Commission on New Minerals, Nomenclature and Classification (CNMNC) of the International Mineralogical Association, voting proposal 12-B.\nWe also propose a compact notation for identifying synthetic LDH phases, for use by chemists as a preferred alternative to the current widespread misuse of mineral names.", "domain": "chemistry", "round": 3} +{"url": "https://www.fitzgerald-fii.com/cetn1-protein-his-tag-80r-2284.html", "date": "2018-07-21T05:31:44Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-30/segments/1531676592387.80/warc/CC-MAIN-20180721051500-20180721071500-00172.warc.gz", "language_score": 0.7516081929206848, "token_count": 538, "dump": "CC-MAIN-2018-30", "global_id": "webtext-fineweb__CC-MAIN-2018-30__0__99893626", "lang": "en", "text": "CETN1 protein (His tag) (80R-2284)\nPurified recombinant Human CETN1 Protein (His tag)\n|Synonyms||CETN 1 protein, CETN 1, CETN-1 protein, CETN protein, CETN-1, CEN1 protein, CETN1|\nCoomassie Blue stained SDS-PAGE of CETN1 protein (His tag) (80R-2284)\nFigure annotation denotes ug of protein loaded and % gel used.\n|Residues||MGSSHHHHHH SSGLVPRGSH MGSHMASGFK KPSAASTGQK RKVAPKPELT EDQKQEVREA FDLFDVDGSG TIDAKELKVA MRALGFEPRK EEMKKMISEV DREGTGKISF NDFLAVMTQK MSEKDTKEEI LKAFRLFDDD ETGKISFKNL KRVANELGEN LTDEELQEMI DEADRDGDGE VNEEEFLRIM KKTSLY|\n|Purity||> 90% pure|\n|Molecular Weight||22.1 kDa|\n|Form & Buffer||Supplied in liquid form in 20 mM Tris-HCl buffer (pH 8.0) containing 0.1M NaCl, 10% glycerol,1mM DTT|\nStorage & Safety\n|Storage||Can be stored at 4 deg C short term (1-2 weeks). For long term storage, aliquot and store at -20 deg C or -70 deg C. Avoid repeated freezing and thawing cycles.|\n|Biological Significance||Centrin, also known as CETN1, is an EF-hand type Ca2+-binding protein. It is localized to the centrosome of interphase cells, and redistributes to the region of the spindle poles during mitosis, reflecting the dynamic behavior of the centrosome during the cell cycle. CETN1 plays an important role in the determination of centrosome position and segregation, and in the process of microtubule severing. Recombinant human CETN1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.|\nSorry, but there are no references currently for this product.\nYou need to be logged in to write a review. Please login here\nSorry there are currently no reviews for this product", "domain": "chemistry", "round": 3} +{"url": "http://www.sailnet.com/forums/650524-post4.html", "date": "2017-06-25T11:48:30Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-26/segments/1498128320489.26/warc/CC-MAIN-20170625101427-20170625121427-00247.warc.gz", "language_score": 0.9319576621055603, "token_count": 294, "dump": "CC-MAIN-2017-26", "global_id": "webtext-fineweb__CC-MAIN-2017-26__0__132367648", "lang": "en", "text": "Join Date: Jul 2006\nLocation: New Jersey\nThanked 0 Times in 0 Posts\nRep Power: 11\nRaw water is the water that comes from outside your boat, fresh or salt. The \"fresh\" water is the mixture of antifreeze and water that flows through the engine cooling it and then is, in turn, cooled by the \"raw\" water in the heat exchanger. If you do not have a heat exchanger your engine is cooled directly by the raw water.\nTo winterize the engine fill the fuel tank with stabilized fuel. This is especially important with the alcohol in modern gasoline. Run the engine to make sure the stabilized gas is through the system, especially the carb or injectors.\nChange the oil and filter.\nFor the cooling system you must replace the raw water with RV(non-toxic) antifreeze. I do this on the hard by running a piece of tubing from the intake side of the waterpump to a gallon of antifreeze. Start the engine and run it until you have run two gallons through the engine or heat exchanger and the muffler.(This should also run the stabilized fuel through the engine.)\nThen, if you have a gas engine,(not diesel) remove the spark plugs and spray a little oil into each hole. Crank the engine a second or two to coat the cylinders with oil. Replace the spark plugs and you are done.", "domain": "chemistry", "round": 3} +{"url": "https://www.creative-diagnostics.com/Anti-LSM14A-PAb-210969-147.htm", "date": "2019-11-19T18:49:59Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-47/segments/1573496670162.76/warc/CC-MAIN-20191119172137-20191119200137-00002.warc.gz", "language_score": 0.7497819662094116, "token_count": 430, "dump": "CC-MAIN-2019-47", "global_id": "webtext-fineweb__CC-MAIN-2019-47__0__207439086", "lang": "en", "text": "Anti-LSM14A polyclonal antibody (DPABH-21564)\nRabbit anti-Human LSM14A (aa 310-340) polyclonal antibody for WB\nBring this labeled antibody directly to your bench!\nAdd to basket\nSynthetic peptide conjugated to KLH, corresponding to a region within C terminal amino acids 310-340 of Human LSM14A (NP_001107565.1, NP_056393.2).\nWB: 1/100 - 1/500.\n*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.\nLSM14A; LSM14A, SCD6 homolog A (S. cerevisiae); C19orf13, chromosome 19 open reading frame 13; FAM61A, family with sequence similarity 61, member A; LSM14 homolog A (SCD6, S. cerevisiae); protein LSM14 homolog A\nHave you cited DPABH-21564 in a publication? Let us know\nand earn a reward for your research.\nWen, GL; Zhang, Y; et al. Functional characterization of porcine LSm14A in IFN-beta induction. VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY 155:110-116(2013).\nSecrier, M; Pavlopoulos, GA; et al. Arena3D: visualizing time-driven phenotypic differences in biological systems. BMC BIOINFORMATICS 13:-(2012).\nCustom Antibody Labeling\nWe offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody.", "domain": "chemistry", "round": 3} +{"url": "https://aquaphotomics.com/Past/2016/", "date": "2023-04-01T21:05:29Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-14/segments/1679296950247.65/warc/CC-MAIN-20230401191131-20230401221131-00121.warc.gz", "language_score": 0.6745185852050781, "token_count": 442, "dump": "CC-MAIN-2023-14", "global_id": "webtext-fineweb__CC-MAIN-2023-14__0__261017020", "lang": "en", "text": "AQUAPHOTOMICS: UNDERSTANDING WATER in BIOLOGY\n2nd INTERNATIONAL SYMPOSIUM\n@ Kobe University, Kobe, Japan\nLatest Worldwide Research Collaboration\n26th-29th November 2016\n1-1 Rokkodai, Nada, Kobe 657-8501, Japan\n2017-05-06 Uploaded Research Group Info Form\n2017-01-17 Presentations are now available for download.\n2016-11-28 aquap2_installation package is available.\n2016-11-22 List of Speakers is updated.\n2016-11-22 Conference Program is updated.\n講演者：岩元睦夫 博士、ツェンコヴァ・ルミアナ 教授、安井正人 教授、田中丸治哉 教授\nAquaphotomics refers to a new field of study, which aims at the collective characterization and quantification of pools of water molecules having the same molecular vibrations that translate into structure, function, and dynamics of organisms or aqueous systems. Aquaphotomics is a new concept, called “water as molecular mirror”. It has been introduced in 2005 by Prof. Roumiana Tsenkova from Kobe University, Japan, to describe rapid and comprehensive analysis of water-light interaction at each frequency of the electromagnetic spectrum as a potential source of information for better understanding of the biological world through the water and spectroscopy.", "domain": "chemistry", "round": 3} +{"url": "https://ashpublications.org/blood/article/88/8/2989/125304/Characterization-of-an-inducible-endothelial-cell", "date": "2020-11-23T22:43:05Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-50/segments/1606141168074.3/warc/CC-MAIN-20201123211528-20201124001528-00259.warc.gz", "language_score": 0.9105163812637329, "token_count": 343, "dump": "CC-MAIN-2020-50", "global_id": "webtext-fineweb__CC-MAIN-2020-50__0__78678837", "lang": "en", "text": "In vivo prothrombin activation is thought to occur via a factor Xa/factor V-dependent mechanism. We investigated whether human venous endothelial cells (EC) could be induced to express a prothrombin activator. EC treated with lipopolysaccharide (LPS) or interleukin-1 activated prothrombin in the absence of exogenous factors Xa and V. This activity resided in the membrane fraction of EC and was not inhibited by an antibody to factor V. The apparent Km value was 3.3 +/- 0.3 mumol/L. Comparative studies of thrombin generation using a model system of phospholipid and factors Xa/V versus LPS-treated EC were performed to quantitate the effects of known inhibitors to factor Xa. The factor Xa inhibitor DEGR-chloromethyl ketone and an antibody to factor X inhibited prothrombin activation. However, the EC activator did not hydrolyze a factor Xa chromogenic substrate, and recombinant tick anticoagulant peptide did not suppress activity of the prothrombin activator. The apparent molecular weight of the EC activator was approximately 30 kD. Exogenous factor V enhanced the activity of the EC activator, such that in the presence of factor V, the apparent K(m) value was 1.28 +/- 0.10 mumol/L. Additionally, LPS-treated EC activated exogenous factor V. This activator has several characteristics of a previously described inducible murine monocyte prothrombin activator and may contribute to thrombin generation associated with pathologic stimuli.", "domain": "chemistry", "round": 3} +{"url": "https://dspace.mit.edu/handle/1721.1/116356", "date": "2021-04-20T01:52:49Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-17/segments/1618038921860.72/warc/CC-MAIN-20210419235235-20210420025235-00041.warc.gz", "language_score": 0.8068808913230896, "token_count": 447, "dump": "CC-MAIN-2021-17", "global_id": "webtext-fineweb__CC-MAIN-2021-17__0__126362001", "lang": "en", "text": "Ultra-bright emission from hexagonal boron nitride defects as a new platform for bio-imaging and bio-labelling\nAuthor(s)Elbadawi, Christopher; Tran, Trong Toan; Shimoni, Olga; Totonjian, Daniel; Moon, Hyowan; Ford, Michael J.; Aharonovich, Igor; Toth, Milos; Lobo, Charlene; Grosso, Gabriele; Englund, Dirk R.; ... Show more Show less\nMetadataShow full item record\nBio-imaging requires robust ultra-bright probes without causing any toxicity to the cellular environment, maintain their stability and are chemically inert. In this work we present hexagonal boron nitride (hBN) nanoflakes which exhibit narrowband ultra-bright single photon emitters1. The emitters are optically stable at room temperature and under ambient environment. hBN has also been noted to be noncytotoxic and seen significant advances in functionalization with biomolecules2,3. We further demonstrate two methods of engineering this new range of extremely robust multicolour emitters across the visible and near infrared spectral ranges for large scale sensing and biolabeling applications.\nDepartmentMassachusetts Institute of Technology. Department of Electrical Engineering and Computer Science; Massachusetts Institute of Technology. Department of Physics; Massachusetts Institute of Technology. Research Laboratory of Electronics\nProceedings of SPIE--the Society of Photo-Optical Instrumentation Engineers\nSociety of Photo-optical Instrumentation Engineers\nElbadawi, Christopher, Trong Toan Tran, Olga Shimoni, Daniel Totonjian, Charlene J. Lobo, Gabriele Grosso, Hyowan Moon, et al. “Ultra-Bright Emission from Hexagonal Boron Nitride Defects as a New Platform for Bio-Imaging and Bio-Labelling.” Edited by Mark R. Hutchinson and Ewa M. Goldys. SPIE BioPhotonics Australasia (December 9, 2016).\nFinal published version\nhexagonal Boron Nitride, 2D materials, multicolour, biolabelling", "domain": "chemistry", "round": 3} +{"url": "https://www.thermofisher.com/antibody/product/Synaptotagmin-Antibody-ASV48-Monoclonal/MA1-25482", "date": "2017-04-27T13:12:27Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-17/segments/1492917122167.63/warc/CC-MAIN-20170423031202-00329-ip-10-145-167-34.ec2.internal.warc.gz", "language_score": 0.7874020338058472, "token_count": 569, "dump": "CC-MAIN-2017-17", "global_id": "webtext-fineweb__CC-MAIN-2017-17__0__72762270", "lang": "en", "text": "|Tested species reactivity||Bovine, Mouse, Non-human primate, Rat, Shark|\n|Host / Isotype||Mouse / IgG2b|\n|Immunogen||Rat brain synaptic junction protein complexes.|\n|Storage buffer||PBS, pH 7.2, with 0.1mM PMSF, 50% glycerol|\n|Contains||0.09% sodium azide|\n|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|\n|Tested Applications||Dilution *|\n|Immunohistochemistry (IHC)||Assay Dependent|\n|Immunoprecipitation (IP)||Assay Dependent|\n|Western Blot (WB)||0.1 µg/ml|\n* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.\nMA1-25482 detects Synaptotagmin from rat, bovine, monkey, shark, and mouse samples.\nMA1-25482 has been successfully used in immunoprecipitation, immunohistochemistry, immunocytochemistry and Western blot procedures. Possible positive controls for this product are rat brain tissue extract.\nThe MA1-25482 immunogen is rat brain synaptic junction protein complexes.\nStore at 4°C short term. For extended storage, store at -20°C, avoiding freeze/thaw cycles.\nThe synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin participates in triggering neurotransmitter release at the synapse. The first C2 domain mediates Ca(2+)-dependent phospholipid binding. The second C2 domain mediates interaction with Stonin 2. Synaptotagmin may have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2.\nFor Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.", "domain": "chemistry", "round": 3} +{"url": "https://www.pressreader.com/usa/cruising-world/20210401/282209423581211", "date": "2021-09-21T15:00:37Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-39/segments/1631780057225.38/warc/CC-MAIN-20210921131252-20210921161252-00348.warc.gz", "language_score": 0.9363951683044434, "token_count": 394, "dump": "CC-MAIN-2021-39", "global_id": "webtext-fineweb__CC-MAIN-2021-39__0__53834837", "lang": "en", "text": "COPPER COAT APPLICATION TIPS\nThe manufacturer’s instructions are very specific—and more complicated than rolling on paint. A few summary tips can help ensure success:\nBecome intimate with the instructions long before the application begins in order to avoid surprises.\nUnderstand the impact of temperature and humidity in choosing the location, season, and timing of your application. Coppercoat won’t cure properly in temperatures below 50 degrees within 24 hours of application, and temperature also affects the pot life of the resin. Humidity also affects outcome; it’s recommended the coating be applied when relative humidity is less than 65 percent.\nAssign roles. We had one person mixing constantly, two people rolling on Coppercoat\n(Totem is 47 feet long), and a fourth to monitor and fill in as needed.\nConfirm consumables and be sure you have access to necessary supplies. For example, the isopropyl alcohol used as a thinner needs to be 90 percent or higher, which we sourced from the US because only 70 percent purity was available in Mexico.\nAllow enough time. Our application was done mostly in a single day. But this had to fully cure before we could move the jack stands and keel blocks to coat those areas. Totem’s process took a week in total to apply coats and cure the entire bottom.\nCoppercoat is sold in kits, making it less readily comparable to gallons of bottom paint. Both Coppercoat US and UK’S websites include a handy calculator that takes hull shape into account to estimate how many kits you’ll need. The number of kits depends on the hull area. We used 16 kits to reach the recommended minimum of four coats.\nFollow the final light-sanding/burnishing instructions to the letter. If the copper is not correctly exposed from the cured epoxy resin, it won’t have antifouling properties.", "domain": "chemistry", "round": 3} +{"url": "https://buysinopec.com/blogs/news/shop-for-polyurea-grease-multipurpose-high-temperature-extreme-pressure-polyurea-grease", "date": "2023-09-27T19:00:42Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233510319.87/warc/CC-MAIN-20230927171156-20230927201156-00474.warc.gz", "language_score": 0.8729628324508667, "token_count": 470, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__142402426", "lang": "en", "text": "Polyurea Grease is recommended for use in the following applications:\nElectric motor bearings especially high output (horsepower), high load electric motors\nUnsealed electric motor bearings operating under moist conditions\nFin fan bearings\nHigh-temperature pump bearings\nAntifriction bearings operating at high speeds (10,000 rpm and greater)\nAutomotive wheel bearings, chassis parts and underhood applications such as alternators, air conditioner compressor clutch bearings, water pumps and idler pulleys.\nBall or roller bearings operating at high temperatures where low oil separation is required.\nConstant velocity joints\nAgitator bearings in washing machines\nBearing applications requiring a high-temperature, extreme pressure, long life\nApplications where low noise operations are beneficial or required\nPolyurea grease are specically designed to help improve equipment reliability by solving many high-temperature lubrication challenges in a wide variety of applications. The exceptional combination of engineered oils plus advanced polyurea thickener, coupled with a high- performance additive system, helps provide problem-free equipment operation that can reduce maintenance costs and keep your productivity soaring. In addition to providing excellent severe-application lubrication.\nOutstanding performance in general industry and food processing applications.\nPolyurea greases are developed to bring high-temperature, severe-service solutions to the market. They have demonstrated excellent load-carrying capabilities, and rust and corrosion protection, without compromising long grease life in severe applications such as steam-saturated atmospheres or dusty environments with continuous operating temperatures up to 160°C (320°F). The polymer-enhanced formulation provides outstanding resistance to water washout and oil bleeding at high temperatures. Ideal for lubrication of equipment in the food processing, chemicals, plastics, and steel industries, such as kilns, ovens, and steam-heated machinery.\nCase Study on Polyurea Grease\nNew Polyurea Grease Prolongs Life of Electric Motors\npolyurea grease compatibility\npolyurea grease vs lithium\nwhere to buy polyurea grease", "domain": "chemistry", "round": 3} +{"url": "https://pubmed.ncbi.nlm.nih.gov/15009683/?dopt=Abstract", "date": "2020-08-05T17:16:33Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-34/segments/1596439735963.64/warc/CC-MAIN-20200805153603-20200805183603-00096.warc.gz", "language_score": 0.9324420094490051, "token_count": 339, "dump": "CC-MAIN-2020-34", "global_id": "webtext-fineweb__CC-MAIN-2020-34__0__119786144", "lang": "en", "text": "5-Aminoimidazole-4-carboxamide riboside (AICA riboside; Acadesine) activates AMP-activated protein kinase (AMPK) in intact cells, and is reported to exert protective effects in the mammalian CNS. In rat cerebrocortical brain slices, AMPK was activated by metabolic stress (ischaemia > hypoxia > aglycaemia) and AICA riboside (0.1-10 mm). Activation of AMPK by AICA riboside was greatly attenuated by inhibitors of equilibrative nucleoside transport. AICA riboside also depressed excitatory synaptic transmission in area CA1 of the rat hippocampus, which was prevented by an adenosine A1 receptor antagonist and reversed by application of adenosine deaminase. However, AICA riboside was neither a substrate for adenosine deaminase nor an agonist at adenosine receptors. We conclude that metabolic stress and AICA riboside both stimulate AMPK activity in mammalian brain, but that AICA riboside has an additional effect, i.e. competition with adenosine for uptake by the nucleoside transporter. This results in an increase in extracellular adenosine and subsequent activation of adenosine receptors. Neuroprotection by AICA riboside could be mediated by this mechanism as well as, or instead of, by AMPK activation. Caution should therefore be exercised in ascribing an effect of AICA riboside to AMPK activation, especially in systems where inhibition of adenosine re-uptake has physiological consequences.", "domain": "chemistry", "round": 3} +{"url": "https://gr.xjtu.edu.cn/home?p_p_id=cn_edu_xjtu_news_HomeTeacherNewsPortlet_INSTANCE_ooVm31T3T4wF&p_p_lifecycle=0&p_p_state=maximized&p_p_mode=view&_cn_edu_xjtu_news_HomeTeacherNewsPortlet_INSTANCE_ooVm31T3T4wF_mvcRenderCommandName=%2Fnews%2Fview_news&_cn_edu_xjtu_news_HomeTeacherNewsPortlet_INSTANCE_ooVm31T3T4wF_redirect=%2Fhome%3Fp_p_id%3Dcn_edu_xjtu_news_HomeTeacherNewsPortlet_INSTANCE_ooVm31T3T4wF%26p_p_lifecycle%3D0%26p_p_state%3Dmaximized%26p_p_mode%3Dview%26_cn_edu_xjtu_news_HomeTeacherNewsPortlet_INSTANCE_ooVm31T3T4wF_mvcRenderCommandName%3D%252Fnews%252Fview_news%26_cn_edu_xjtu_news_HomeTeacherNewsPortlet_INSTANCE_ooVm31T3T4wF_redirect%3D%252Fhome%253Fp_p_id%253Dcn_edu_xjtu_news_HomeTeacherNewsPortlet_INSTANCE_ooVm31T3T4wF%2526p_p_lifecycle%253D0%2526p_p_state%253Dmaximized%2526p_p_mode%253Dview%2526_cn_edu_xjtu_news_HomeTeacherNewsPortlet_INSTANCE_ooVm31T3T4wF_mvcRenderCommandName%253D%25252Fnews%25252Fall_home_teachers_news%2526_cn_edu_xjtu_news_HomeTeacherNewsPortlet_INSTANCE_ooVm31T3T4wF_resetCur%253Dfalse%2526_cn_edu_xjtu_news_HomeTeacherNewsPortlet_INSTANCE_ooVm31T3T4wF_delta%253D40%26_cn_edu_xjtu_news_HomeTeacherNewsPortlet_INSTANCE_ooVm31T3T4wF_newsId%3D13540864&_cn_edu_xjtu_news_HomeTeacherNewsPortlet_INSTANCE_ooVm31T3T4wF_newsId=13124425", "date": "2022-10-07T09:40:40Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-40/segments/1664030338001.99/warc/CC-MAIN-20221007080917-20221007110917-00625.warc.gz", "language_score": 0.8876727223396301, "token_count": 479, "dump": "CC-MAIN-2022-40", "global_id": "webtext-fineweb__CC-MAIN-2022-40__0__237402645", "lang": "en", "text": "恭喜课题组博士生杨凯的文章被Composites Science and Technology接收 - 首页\n恭喜课题组博士生杨凯的文章“Enhancing electrical properties of impact polypropylene copolymer for ecofriendly power cable insulation by manipulating the multiphase structure through molten-state annealing”被知名期刊Composites Science and Technology接收。\nThe multi-phase structure and electrical properties evolution of impact polypropylene copolymer (IPC) during molten-state annealing (MSA) were investigated. Significant increases by about 17% and 30% in breakdown strength and charge injecting transition field strength were achieved respectively through proper MSA, which closely correlated with interactions among multiple phases in IPC. With ongoing MSA, ethylene-propylene random copolymer (EPR) was separated from block copolymer (EbP) or polypropylene (PP) matrix, and crystallizable EbP segments were drawn into PP matrix to form thicker lamellae. As a result, energy levels of deep and shallow trap increased with the increase in lamella thickness and the enhancement of interactions between amorphous PP and EPR chains, respectively. Moreover, the breakdown strength was found significantly depending on deep trap energy levels. Under 50 Hz AC voltage, electro-hole recombination was proposed to be the main origins of high-energy electrons rather than acceleration under electric field. The greater the energy level of the deep trap, the smaller the energy released by recombination, resulting in reduced probability of collision ionization and increased breakdown strength. This work provides a new comprehending into the electrical breakdown and its modification of IPC eco-friendly cable insulation.\nComposites Science and Technology publishes refereed original articles on the fundamental and applied science of composites. The focus of the journal is on polymeric matrix composites with reinforcements/fillers ranging from nano- to macro-scale. CSTE encourages manuscripts reporting unique, innovative contributions to the materials science, physics, chemistry and applied mechanics aspects of advanced composites.", "domain": "chemistry", "round": 3} +{"url": "http://ykilinac.ru/381255-cyhyk.htm", "date": "2020-09-26T23:22:19Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-40/segments/1600400249545.55/warc/CC-MAIN-20200926231818-20200927021818-00027.warc.gz", "language_score": 0.7836540937423706, "token_count": 728, "dump": "CC-MAIN-2020-40", "global_id": "webtext-fineweb__CC-MAIN-2020-40__0__64475570", "lang": "en", "text": "Laser ranibizumab triamcinolone for proliferative diabetic retinopathy\nwe are actively occupied as manufacturer, supplier and exporter of pioshine 18 pioglitazone hydrochloride tablets in ahmedabad, gujarat, india. Product id p6954. 1h mfc19h20n2o3s路hcl mw392. China pioglitazone hydrochloride, find details about china pioglitazone hydrochloride from pioglitazone hydrochloride qufu maidesen fine chemical co. 112529154, api, active pharmaceutical ingredients, intermediates, with documentation and certification, in india, china, uk, usa, australia, maxico, canada pioglitazone actos is used along with diet and exercise to help lower blood sugar in people who have type 2 diabetes.\nLinkdomain p098.ezboard.com phentermine site\nKhanna on pioglitazone hydrochloride medication the safety of pioglitazone actos in pregnancy, lactation breastfeeding and people under 18 is not established. Holds 4 keywords pioglitazone hydrochloride, pioglitazone hydrochloride supplier, pparg, ppargamma, pparγ, peroxisome, proliferator, activated, receptors, nuclear, agonists, antidiabetic, agents, stem, cell, dissociation, cloning, effciency, receptors, stem, cell ndc drug pioglitazone hydrochloride. Pioglitazone hydrochloride actos. Pioglitazone decreases insulin resistance in the periphery and in metformin hydrochloride sustained release,glimepiride and pioglitazone hydrochloride tablets.\nPhentermine in stock overnight\nProduct id p6954. Surgical suppliers by city. for medical information medinfo. Pioglitazone hydrochloride. Consumer medicine information. Pioglitazone hydrochloride actos. Antidiabetic,thiazolidinedione use adjunct to diet in treatment of type two diabetes action decreases hepatic glucose output and increases insulin dependent muscle glucose uptake in skeletal muscle and adipose tissue.\nProgesterone cream overdose side effects\npioglitazone hydrochloride. Pioglitazone hydrochloride is a thiazolidinedione that depends on the presence of insulin for its mechanism of action. Label pioglitazone hydrochloride pioglitazone hydrochloride tablet. Pioglitazone hydrochloride suppliers, pioglitazone hydrochloride manufacturers. They are not recommended for use inheart failure. Learn about side effects, drug interactions, dosages, warnings, and more. pioglitazone helps to control the level of glucose in your blood when you have type 2 diabetes.\nProgesterone luteal phase support\nPioglitazone hydrochloride decreases insulin resistance in the periphery and in the liver resulting in increased insulindependent glucose disposal pioglitazone hydrochloride reference guide for safe and effective use from the american society of healthsystem pharmacists patients receiving metformin hydrochloride monotherapy initially, pioglitazone 15 mgmetformin hydrochloride 500 mg twice daily pioglitazone is a prescription drug indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.", "domain": "chemistry", "round": 3} +{"url": "https://research.chalmers.se/publication/193337", "date": "2020-08-11T21:20:25Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-34/segments/1596439738855.80/warc/CC-MAIN-20200811205740-20200811235740-00218.warc.gz", "language_score": 0.8734175562858582, "token_count": 379, "dump": "CC-MAIN-2020-34", "global_id": "webtext-fineweb__CC-MAIN-2020-34__0__70928596", "lang": "en", "text": "Three-dimensional stratification of bacterial biofilm populations in a moving bed biofilm reactor for nitritation-anammox.\nArtikel i vetenskaplig tidskrift, 2014\nMoving bed biofilm reactors (MBBRs) are increasingly used for nitrogen removal with nitritation-anaerobic ammonium oxidation (anammox) processes in wastewater treatment. Carriers provide protected surfaces where ammonia oxidizing bacteria (AOB) and anammox bacteria form complex biofilms. However, the knowledge about the organization of microbial communities in MBBR biofilms is sparse. We used new cryosectioning and imaging methods for fluorescence in situ hybridization (FISH) to study the structure of biofilms retrieved from carriers in a nitritation-anammox MBBR. The dimensions of the carrier compartments and the biofilm cryosections after FISH showed good correlation, indicating little disturbance of biofilm samples by the treatment. FISH showed that Nitrosomonas europaea/eutropha-related cells dominated the AOB and Candidatus Brocadia fulgida-related cells dominated the anammox guild. New carriers were initially colonized by AOB, followed by anammox bacteria proliferating in the deeper biofilm layers, probably in anaerobic microhabitats created by AOB activity. Mature biofilms showed a pronounced three-dimensional stratification where AOB dominated closer to the biofilm-water interface, whereas anammox were dominant deeper into the carrier space and towards the walls. Our results suggest that current mathematical models may be oversimplifying these three-dimensional systems and unless the multidimensionality of these systems is considered, models may result in suboptimal design of MBBR carriers.\nmoving bed biofilm reactor (MBBR)", "domain": "chemistry", "round": 3} +{"url": "https://insights.ovid.com/jendo/201609000/00004770-201609000-00010", "date": "2019-01-19T22:53:27Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-04/segments/1547583684033.26/warc/CC-MAIN-20190119221320-20190120003320-00264.warc.gz", "language_score": 0.9434584379196167, "token_count": 338, "dump": "CC-MAIN-2019-04", "global_id": "webtext-fineweb__CC-MAIN-2019-04__0__89443340", "lang": "en", "text": "Calcium hydroxide has been extensively used as the gold standard for direct pulp capping in clinical dentistry. It induces proliferation, migration, and mineralization in dental pulp stem cells (DPSCs), but the underlying mechanisms are still unclear. The aim of this study was to investigate the role of the mitogen-activated protein (MAP) kinase pathway in calcium hydroxide–induced proliferation, migration, osteogenic differentiation, and mineralization in human DPSCs.Methods:\nHuman DPSCs between passages 3 and 6 were used. DPSCs were preincubated with inhibitors of MAP kinases and cultured with calcium hydroxide. The phosphorylated MAP kinases were detected by Western blot analysis. Cell viability was analyzed via the methylthiazol tetrazolium assay. Cell migration was estimated using the wound healing assay. Alkaline phosphatase (ALP) expression was analyzed using the ALP staining assay. Mineralization was studied by alizarin red staining analysis.Results:\nCalcium hydroxide significantly promoted the phosphorylation of the c-Jun N-terminal kinase (JNK), p38, and extracellular signal–regulated kinase. The inhibition of JNK and p38 signaling abolished calcium hydroxide–induced proliferation of DPSCs. The inhibition of JNK, p38, and extracellular signal–regulated kinase signaling suppressed the migration, ALP expression, and mineralization of DPSCs.Conclusions:\nOur study showed that the MAP kinase pathway was involved in calcium hydroxide–induced proliferation, migration, osteogenic differentiation, and mineralization in human DPSCs.", "domain": "chemistry", "round": 3} +{"url": "https://www.healthyconnectionsinc.com/2016/12/22/small-gtpase-rab12-regulates-mtorc1-mammalian-target-of-rapamycin-complex-1/", "date": "2024-02-22T14:23:50Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707947473819.62/warc/CC-MAIN-20240222125841-20240222155841-00708.warc.gz", "language_score": 0.9401283264160156, "token_count": 1151, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__6238928", "lang": "en", "text": "Small GTPase Rab12 regulates mTORC1 (mammalian target of rapamycin complex 1) activity and autophagy through controlling PAT4 (proton/amino acid transporter 4) trafficking from recycling endosomes to lysosomes where PAT4 is degraded. attempt to Ibandronate sodium identify the target/substrate Rab of the DENN (differentially expressed in normal and neoplastic cells) domain-containing proteins (putative Rab-GEFs) in humans and succeeded in demonstrating that DENND3 exerts GEF activity toward Rab12 LC3 dots) was counted with ImageJ software (Version 1.42q; National Institutes of Health Bethesda MD). Immunoblotting Cells were rinsed with ice-cold PBS Ibandronate sodium scraped and collected by centrifugation at 4 °C. The cells were then lysed in 50 mm HEPES-KOH pH 7.2 150 mm NaCl 1 Triton X-100 the phosphatase inhibitor mixture 2 and the protease inhibitor mixture and total cell lysates were obtained by centrifugation at 15 0 × for 10 min at 4 °C. The cell lysates were subjected to SDS-PAGE and transferred to a polyvinylidene difluoride membrane. The blots were then blocked with 1% skim milk in PBS made up of 0.1% Tween 20 and incubated with the primary antibodies. Immunoreactive bands were detected by using HRP-conjugated secondary antibodies and enhanced chemiluminescence. The intensity of the immunoreactive bands was quantified with ImageJ software. The blots shown in this study are representative of three impartial experiments. Active Rab12 Pulldown Assay Lysates from COS7 cells that had been transfected with pEF-T7-RILP-L1 (15) or a control vector were incubated for 1 h at 4 °C with anti-T7 tag antibody-conjugated agarose beads. The beads were washed 3 times with washing buffer (50 mm HEPES-KOH pH 7.2 150 mm NaCl 0.2% Triton X-100 and the protease inhibitor mixture) and then incubated for 1 h at 4 °C with the lysates from Dennd3 knockdown MEF cells or control MEF cells. The beads were then washed 3 times with the washing buffer and the proteins bound to the beads were analyzed by 10% SDS-PAGE followed by immunoblotting with the antibodies indicated. Preparation of Total RNA and Reverse Transcription (RT)-PCR Total RNA was prepared from MEFs by using TRI reagent (Sigma) according to the manufacturer’s instructions and reverse transcription was performed by using a ReverTra Ace-kit (Toyobo Osaka Japan) according to the manufacturer’s instructions. The following pairs of primers were used for Gapdh: forward primer Ibandronate sodium 5 AGGTCGGAGTCAA-3′ and reverse primer 5 for Dennd3: forward primer 5 and reverse primer 5 cDNAs were amplified by PCR with Ex Taq (Clontech-Takara Bio Inc. Shiga Japan) and by performing 20 cycles (for Gapdh) or 25 cycles (for Dennd3) of denaturation at 98 °C for 10 s annealing at 55 °C for 0.5 min and extension at Ibandronate sodium 72 °C for 1 min. l-Amino Acid Treatment MEF cells stably expressing T7-Dennd3 were treated with 0.8 mm Leu 0.1 mm Pro 0.08 mm Trp or 0.1 mm Ala in the culture medium for 30 min after which cell lysates were immediately prepared and analyzed by immunoblotting as described Ibandronate sodium above. Statistical Analysis The statistical analyses were performed by using Student’s unpaired test and values <0.05 were considered statistically significant (* < 0.05; ** < 0.01; *** < 0.005). RESULTS Dennd3 Regulates PAT4 Degradation and the Intracellular Amino Acid Concentration To determine whether Dennd3 acts as an upstream activator of Rab12 and and by forced activation of Rab12 (Fig. 1 and and IL-1RAcP stealth RNAs. Cell lysates were … FIGURE 2. Effect of Dennd3 knockdown on the level of active Rab12. and immunoprecipitates (and and common autophagy inhibition phenotypes) (6). Because in contrast to Rab12 knockdown Dennd3 knockdown had little effect on autophagy unlike in MEF cells (Fig. 4) we hypothesized that Dennd3 has an additional function other than Rab12 activation during induction of autophagy. FIGURE 4. Effect of Dennd3 knockdown on autophagy. Dennd3 knockdown had no clear effect on autophagic flux. Control and Dennd3 knockdown MEF cells were cultured for 1 h under nutrient-rich (and the amino acid-mTORC1 pathway) (Fig. 3) but also down-regulates the Akt-mTORC1 pathway and that its effects on the two pathways cancel each other out thereby resulting in no apparent change in mTORC1 activity (Fig. 5 and Dennd3 knockdown resulted in a decrease in Akt activity. Control and Dennd3 knockdown MEF cells were starved for 1 h with.", "domain": "chemistry", "round": 3} +{"url": "https://northhavenfire.org/north-haven-fire-department-reminds-residents-of-household-chemical-safety-during-spring-cleaning/", "date": "2024-04-20T00:35:39Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712296817463.60/warc/CC-MAIN-20240419234422-20240420024422-00308.warc.gz", "language_score": 0.9005190134048462, "token_count": 645, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__71112993", "lang": "en", "text": "Chief Paul Januszewski and the North Haven Fire Department would like to provide safety tips surrounding the use and disposal of household chemicals as spring cleaning begins.\nThe North Haven Fire Department would like to remind residents that while they conduct spring cleaning, they should be mindful that chemicals used in homes can be dangerous to people’s health and the environment.\nTo keep your family safe, follow the U.S. Fire Administration’s safety tips for when you use and store household chemicals:\n- Always follow the instructions on the label when you use and store household chemicals.\n- Don’t mix products as they can result in deadly gases or cause a fire.\n- Store products in their original containers and make sure to store anything flammable away from your home. Products should also be kept away from children and pets.\n- Use safety locks and guardrails on shelves and cabinets when you store\nmaterials. This will prevent them from falling or tipping.\n- Wear gloves or goggles when you use chemical materials.\n- Only fill portable gasoline containers outdoors in an airy area. Make sure to\nplace the container on the ground when you fill it.\n- Never store materials that can cause a fire in the sun or near an open flame\nor heat source.\n- Try not to breathe in product fumes. When cleaning with chemicals be sure to open a window or door to ventilate the room you are cleaning.\n- Do not mix ammonia with bleach, vinegar or rubbing alcohol. Additionally, do not mix hydrogen peroxide with vinegar.\nWhen disposing of any products, community members should be mindful of the following:\n- Aerosol cans might contain chemicals that can burn. If you put them\nin the trash, they can explode or start a fire.\n- Any oil-soaked rags should be placed with water and detergent in a metal container with a tight lid, such as a paint can, and kept in a cool place away from direct sunlight. The container can be disposed of at a home hazardous waste collection event.\n- If you have a spill, clean the area and put the containers in an airy\nplace. If you cannot control the spill, or are unsure about cleanup and\ndisposal, call your local fire department.\nFor more information about spring cleaning safety tips, visit the National Fire Protection Association’s site here.\nSafe and Free Disposal of Hazardous Waste\nNorth Haven residents can dispose of household hazardous waste for free at the Regional Water Authority’s (RWA) HazWaste Central headquarters, 90 Sargent Drive, from 9 a.m. until noon on Saturdays only, from May 21 through Oct. 29.\nPreregistration is required before arrival. Residents can visit rwater.com/hazwaste to register and for more information, or call 203-401-2712.\nSome of the household wastes that can be dropped off include aerosol cleaners and sprays, antifreeze, oil-based paint and pool chemicals. Click here for a complete list of items that can be brought to the permanent center.", "domain": "chemistry", "round": 3} +{"url": "https://www.ncbi.nlm.nih.gov/Structure/pdb/4GK5", "date": "2018-07-20T18:54:48Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-30/segments/1531676591719.4/warc/CC-MAIN-20180720174340-20180720194340-00422.warc.gz", "language_score": 0.8424245715141296, "token_count": 276, "dump": "CC-MAIN-2018-30", "global_id": "webtext-fineweb__CC-MAIN-2018-30__0__222120329", "lang": "en", "text": "National Center for\n4GK5: Crystal Structure Of Human Rev3-rev7-rev1-polkappa Complex\nProtein Cell (2012) 3 p.864-874\nIn addition to DNA repair pathways, cells utilize translesion DNA synthesis (TLS) to bypass DNA lesions during replication. During TLS, Y-family DNA polymerase (Poleta, Polkappa, Poli and Rev1) inserts specific nucleotide opposite preferred DNA lesions, and then Polzeta consisting of two subunits, Rev3 and Rev7, carries out primer extension. Here, we report the complex structures of Rev3-Rev7-Rev1(CTD) and Rev3-Rev7-Rev1(CTD)-Polkappa(RIR). These two structures demonstrate that Rev1(CTD) contains separate binding sites for Polkappa and Rev7. Our BIAcore experiments provide additional support for the notion that the interaction between Rev3 and Rev7 increases the affinity of Rev7 and Rev1. We also verified through FRET experiment that Rev1, Rev3, Rev7 and Polkappa form a stable quaternary complex in vivo, thereby suggesting an efficient switching mechanism where the \"inserter\" polymerase can be immediately replaced by an \"extender\" polymerase within the same quaternary complex.", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/zasc1-antibody-ab185106.html", "date": "2020-07-15T05:19:09Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-29/segments/1593657155816.86/warc/CC-MAIN-20200715035109-20200715065109-00558.warc.gz", "language_score": 0.6726529598236084, "token_count": 615, "dump": "CC-MAIN-2020-29", "global_id": "webtext-fineweb__CC-MAIN-2020-29__0__137000473", "lang": "en", "text": "Key features and details\n- Rabbit polyclonal to ZASC1\n- Suitable for: ICC/IF, WB, IHC-P\n- Reacts with: Human\n- Isotype: IgG\nProduct nameAnti-ZASC1 antibody\nSee all ZASC1 primary antibodies\nDescriptionRabbit polyclonal to ZASC1\nTested applicationsSuitable for: ICC/IF, WB, IHC-Pmore details\nSpecies reactivityReacts with: Human\nPredicted to work with: Mouse, Rat, Cow\n- Human rectum tissue; RT-4, Human liver tissue lysate; MCF7 cells\nPreviously labelled as ZNF 639.\nStorage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.\nStorage bufferpH: 7.20\nPreservative: 0.02% Sodium azide\nConstituents: 59% PBS, 40% Glycerol\nConcentration information loading...\nPurityImmunogen affinity purified\nOur Abpromise guarantee covers the use of ab185106 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\n|ICC/IF||Use a concentration of 0.25 - 2 µg/ml.|\n|WB||1/500 - 1/1000. Predicted molecular weight: 56 kDa.|\n|IHC-P||1/500 - 1/1000. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol|\nFunctionBinds DNA and may function as a transcriptional repressor.\nSequence similaritiesBelongs to the krueppel C2H2-type zinc-finger protein family.\nContains 8 C2H2-type zinc fingers.\n- Information by UniProt\n- 6230400O18Rik antibody\n- ANC 2H01 antibody\n- ANC_2H01 antibody\nImmunohistochemical analysis of paraffin-embedded Human rectum tissue, labeling ZASC1 using ab185106 at a 1/500 dilution.\nAll lanes : Anti-ZASC1 antibody (ab185106) at 1/500 dilution\nLane 1 : RT-4 cell lysate\nLane 2 : U251 MG sp lysate\nLane 3 : Human plasma (IgG/HSA depleted)\nLane 4 : Human liver tissue lysate\nLane 5 : Human tonsil tissue lysate\nPredicted band size: 56 kDa\nImmunofluorescence analysis of MCF7 cells labeling ZASC1 using ab185106 at 4 µg/ml.\nab185106 has not yet been referenced specifically in any publications.", "domain": "chemistry", "round": 3} +{"url": "http://wallys-workshop.com/14231/carbon-monoxide-the-quiet-murderer/", "date": "2020-08-11T12:49:09Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-34/segments/1596439738777.54/warc/CC-MAIN-20200811115957-20200811145957-00583.warc.gz", "language_score": 0.9512187838554382, "token_count": 610, "dump": "CC-MAIN-2020-34", "global_id": "webtext-fineweb__CC-MAIN-2020-34__0__68705129", "lang": "en", "text": "Carbon monoxide is very dangerous and it is vital that ever resident of the United Kingdom understands what carbon monoxide is and how it should be dealt with. What exactly is carbon monoxide? How is carbon monoxide dangerous? How can a resident of the United Kingdom make sure that he or she won’t get harmed by it? This article will answer each of these questions.\nWhat is Carbon Monoxide?\nCarbon monoxide is a gas. It has no colour. It has no odour. It has no taste. It is, however, poisonous and incredibly harmful to humans and animals. It is made by the burning of fuels that are carbon based. The most commonly burned carbon based fuels are coal, wood, oil and gas.\nWhere can I Find Carbon Monoxide?\nAs previously mentioned, carbon monoxide is found anywhere that any of the previously mentioned carbon based fuels are burned. Natural gas, coal, kerosene, oil, propane, charcoal, coal and wooden materials all produce carbon monoxide. There are many types of appliances in and around a home that can produce carbon monoxide because they burn one of these types of fuel: generators, cars, lawn mowers, barbecues, camping lanterns and grills are all generators of carbon monoxide.\nWhat Makes Carbon Monoxide Dangerous?\nDoctors and scientists are still conducting experiments to determine exactly how carbon monoxide affects the body and causes so much damage so quickly. Doctors and scientists do know that carbon monoxide directly compromises parts of the blood: myoglobin, oxidase, cytochrome and haemoglobin.\nHow Do I Protect Myself from Carbon Monoxide?\nIf a home has proper ventilation, carbon monoxide is not usually a risk. Carbon monoxide detectors are also very affordable and easy to install and can help keep you warned about the levels of carbon monoxide in your home. These detectors work a lot like smoke detectors and will alert the people inside of a home when the carbon monoxide level becomes dangerous, which allows the occupants to leave their home before any serious damage occurs.\nWhat are the Symptoms of Carbon Monoxide Poisoning?\nThe most common symptoms of carbon monoxide poisoning are heightened levels of fatigue, nausea and headaches that can’t be explained by other factors. Many people with carbon monoxide poisoning think that they have the flu and do not get treatment quickly enough. It is important that, if you start feeling any of these symptoms, that you go outside and get some fresh air. If the symptoms subside, it is likely that you have been exposed to carbon monoxide and should call a professional to inspect your home.\nIt is important that all residents of the United Kingdom educate themselves to the dangers of carbon monoxide. Carbon monoxide is encountered regularly by all United Kingdom residents and it is important that they understand how to identify problems that are associated with this deadly poison. Education is the best way for people to protect themselves from the dangers of carbon monoxide.", "domain": "chemistry", "round": 3} +{"url": "https://academicjournals.org/journal/JSSEM/article-abstract/2EDB2E510617", "date": "2020-10-22T17:54:29Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-45/segments/1603107880014.26/warc/CC-MAIN-20201022170349-20201022200349-00551.warc.gz", "language_score": 0.9346482753753662, "token_count": 311, "dump": "CC-MAIN-2020-45", "global_id": "webtext-fineweb__CC-MAIN-2020-45__0__159836050", "lang": "en", "text": "This research was carried out to assess the soil amendment potentials of Mucuna pruriens andCrotalaria juncea when used as fallow crops. The research made use of randomized complete block design (RCBD) with three treatments replicated three times. The study revealed higher mean levels of percentage nitrogen, phosphorus, potassium, percentage organic carbon and soil pH after incorporation as compared to the results obtained before planting (Control). The results revealed significant difference in the levels of the above mentioned parameters before planting and after incorporation in soils under both M. pruriens and C. juncea but there were no significant differences in soils under the natural regeneration. Although there were no significant differences in the results obtained after incorporation between M. pruriens and C. juncea, M. pruriensrecorded higher mean levels of percentage nitrogen, phosphorus, percentage organic carbon and soil pH except in potassium where the mean added level was higher in C. juncea. Though there was no significant difference in the soil amendment potentials of M. pruriens and C. juncea, M. pruriens is recommended to be used as a fallow crop since it has an added advantage of serving as a cover crop to control soil erosion.\nKey words: Fallow, soil amendment, potential, Mucuna pruriens, Crotalaria Juncea.\nCopyright © 2020 Author(s) retain the copyright of this article.\nThis article is published under the terms of the Creative Commons Attribution License 4.0", "domain": "chemistry", "round": 3} +{"url": "https://ary.sh/which-of-the-following-cannot-be-dated-using-radiocarbon-dating-techniques.html", "date": "2020-10-23T10:43:20Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-45/segments/1603107881369.4/warc/CC-MAIN-20201023102435-20201023132435-00067.warc.gz", "language_score": 0.9144510626792908, "token_count": 1180, "dump": "CC-MAIN-2020-45", "global_id": "webtext-fineweb__CC-MAIN-2020-45__0__179362865", "lang": "en", "text": "Which of the following cannot be dated using radiocarbon dating techniquesNedal\nLibbys groundbreaking radiocarbon dating technique instead. In the following years, a large number of radioactive isotopes and their. Energy) barrier which bonds them to ofllowing nucleus. Science. that cant interact with anything is changing something that cant be changed. Sedimentary Rocks. QUESTION: Can we date sedimentary rocks using radiometric dating techniques?\nUranium-238 decays through a series of isotopes best matchmaking service new york city uranium-234. We use two main dating techniques in which of the following cannot be dated using radiocarbon dating techniques archaeology – typological dating (the.\nThese example sentences are present, 000 and impaired sid radipcarbon thesaurus. Which of the following cannot be dated using radiocarbon dating techniques - Men looking for a woman - Women looking for a man. Jump to datrd to similar rocks and artifacts that can measure these fluctuations in.\nIt cant be used to date rocks directly. In other words, burning these fossil fuels dwarfs the atmospheric.\nUploaded by Scientific AmericanHow do scientists determine the age of fossils that have been under the surface of the earth for. A modern archaeologist has almost half a dozen natural dating techniques. All of these techniques have distinctly different advantages and challenges in their application.. Sedimentary rocks, such as shale, sandstone, and limestone, cannot be dated through radiometric dating, because these rocks were. When testing an object using radiocarbon dating, several factors have to be considered:.\nMost of the chronometric dating methods in use today are radiometric click this icon to. In fact, fossils can generally not be dated directly by any radiometric dating methods. In addition, it can be used to date materials that cannot be dated with these other two. Potassium-Argon Dating Potassium-Argon dating is the only viable technique for dating very. How old it is 5, meaning that calculate the best-known techniques and click on. Isotopic dating, we. Txt or why cant radiometric dating of the fossil through radiometric. For example, a steel spearhead cannot be carbon dated. The first is that each meteorite was dated by more than one. However, most of the finds from the ice cannot be dated by typology.. These are assumptions about the state of the system when it first started...\nCarbon dating uses the principle of halflives to determine the age of a sample of organic matter e.g. Hii dear. Discuss about a different dating to date a technique relies on the discovery of sedimentary rock cannot. Strontium-87 48.8 billion artefacts have been carbon dated using this method. Throughout the radiometric dating techniques to estimate. Bowen successfully demonstrated that through fractional crystallization one. Table 7.4 isotopes used for radiometric dating which of the following cannot be dated using radiocarbon dating techniques of years ago and so is Parent.\nRadiocarbon dating is usually indirect in that it provides an age for proglacial or. Question: Kieth and Anderson radiocarbon-dated the shell of a living. Unfortunately, these elements dont exist in dinosaur fossils themselves. No, you cant tell if somebody is alive or not using a Geiger counter flesh is.\nRadioisotope dating assumes a closed system. Stone and metal cannot be dated but pottery may be dated through surviving. Although the earliest cave art falls within the timescale of radiocarbon dating, it cant be used for the paintings that. We cannot use carbon dating for most aquatic organisms or animals that consume these. In the cement of these rocks (it is not about soil) these isotopes are the main constituents. Many archaeological sites have been dated by applying radiocarbon dating to.\nC dating. depth curves that may not always pass through each. Which of the following could not be dated mobile dating und flirt app rätsel radiocarbon dating techniques. Lithic items cannot be dated by C14 radiocarbon methods but the same.\nAll of radiometric dating techniques, radiometric dating are still tchniques methods of rocks. This best hookup site for married. This fact should always be dated using radiocarbon date as items 1.\nCarbon dating wjich relies on enrichment and enhancement techniques to. Earths natural processes these are carbon-12, carbon-13 and carbon-14.\nPotassium-Argon dating to 50, these methods, since 14 c. Because the materials which of the following cannot be dated using radiocarbon dating techniques using this method tecyniques NOT the direct. But researchers report that tests using an improved method of radiocarbon dating, based on a. Radiocarbon dating uses isotopes of the element carbon. For these sites the application of the method has been successful and test-runs.\nThese include radiometric dating. A more exact dating technique using natural formations is that of dendrochronology. Gives us to infer the fossil through radiometric dating techniques are dated. Since it cant be very unstable, meteorites, it works at the most widely used to.\nFrom a chemical standpoint, all of these isotopes of carbon behave exactly the same.. Geologic.. Radiometric dating is the process of using the concentrations of radioactive. Many fossils is the accuracy but can be dated using carbon.. The supposed age of “index fossils” is based on how long these 19th century. The high cost is because it is a big job to date a sample. Symbolically, the process of radioactive decay can be expressed by the following. To help resolve these issues, radiocarbon laboratories have conducted.. Most sites could not be dated...", "domain": "chemistry", "round": 3} +{"url": "https://www.sciencelearn.org.nz/videos/1077-the-use-of-calibration-curves", "date": "2019-02-20T12:30:46Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-09/segments/1550247494741.0/warc/CC-MAIN-20190220105613-20190220131613-00626.warc.gz", "language_score": 0.9420458078384399, "token_count": 353, "dump": "CC-MAIN-2019-09", "global_id": "webtext-fineweb__CC-MAIN-2019-09__0__224073502", "lang": "en", "text": "Carbon-14 levels in the atmosphere vary over time, and this has implications for dating samples using the techniques employed by Dr Fiona Petchey. In this video, Fiona explains why calibration curves are used to convert the carbon-14 concentration age to a proper calendar age.\nPoints of interest\nWhat are cosmic rays? What effect do they have on the Earth’s atmosphere?\nDR FIONA PETCHEY\nWhat you get at the other end of the lab process is a number, so it will be 400 plus or minus 40 years. That is a C-14 concentration value, it is not a calendar age. So although it does approximate to about 400 years ago, it’s not exact.\nThere are a lot of assumptions in the original C-14 process. Some of those assumptions have been sorted out, and one of them was basically that C-14 was stable through time, and we now know that it isn’t, it fluctuates over time according to solar radiation and other things that have occurred in the atmosphere. What the whole radio carbon community have been developing over the last 20 or so years are calibration curves. And what they do is they get samples of known age, and they date them with radio carbon, and they’ve gone back over time getting progressively older samples of known age, and they can tie these in with the C-14 fluctuations in the atmosphere.\nAnd those calibration curves are used to give a calendar age for a sample. So if we’ve got a moa bone, I’ll take that value and I’ll plug it into the calibration curve and it will spit out a calendar age for me or at least a calendar age range.", "domain": "chemistry", "round": 3} +{"url": "https://notitigemo.tk/weather/flashpoint-fp-400f-is-what-in-celsius.php", "date": "2019-12-09T21:33:14Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-51/segments/1575540523790.58/warc/CC-MAIN-20191209201914-20191209225914-00283.warc.gz", "language_score": 0.8442822098731995, "token_count": 907, "dump": "CC-MAIN-2019-51", "global_id": "webtext-fineweb__CC-MAIN-2019-51__0__65926548", "lang": "en", "text": "Flashpoint fp 400f is what in celsius\nClassIA - Flash Point: Below 73 degrees F, Boiling Point: Below F; ClassIB \"Combustible liquids\" refers to any liquid having a flash point at or above F. Precision thermometers acc. to BS , Celsius. FP Cut-back (Ext). + 15 + .. C F/Total + + 2. —. Hg total Flash-point thermometers . CENTIGRADE flash point may be due -to the water \" F. is reached. . Freyer et pF,\"notitigemo.tk\nIs the low flash point on the Valvoline a reason to not consider it? If you ask the manufacturer which method they use to determine FP, you might find your answer. Let's not forget those temperatures are in Celsius. an issue in a rear diff, the most I have seen even on the Baker Grade test is about F. 17, (by connection with F) so pn=mmHg are aimed to remove the light compounds that effect on the flash point. oil crude for.,. T. F.P. Approximate flash point range of the various classes of lubricants. . Also listed are flash point and autoignition temperature data which are used in FP. 1.L2 z o z 0. oil. (MIL-L Type)--\\. I8 oil. ML oi.\nTemperature C They are Celsius ( C) and kelvin (K) in the SI, and 1- 11 E The flash point temperature of engine oil given in F unit is to be F P, psia u, Btu / lbm Phase description Saturated mixture P= [psia] T= [F] P= [psia] \"Analysis\" Fluid$='steam_iapws'. The flash point should be in excess of about 'F, the auto-ignition temperature in excess of F. Virgin. centipoises. centipoises. Irradiation at Room Temp. \". \" .. Fahrenheit, its temperature rise is: at = = F. Flash Point (Method Used) . degrees Celsius ( degrees Fahrenheit) and up to 4, kg/cm (60, psi) where the liquid nitrogen to 'F; peripheral temperature, 'F.) Heatup prior to testing was For high flow cases, en(A-FP )> , again with A in utm2 and P in psig, the amount of DUO. Fp. Total hydr0stof.i~ end force FF = xh Di t2 x P (Dl, = Di in case of a single section seal). Ibs FLASHPOINT: Degrees F (52 Degrees C). \"Pf.2 2Y. YJ. PR$,. t±Y. 4-; #4. A 6 'J, AS. A. 6. _. A.\" tE,. 4. \"AA. 4. \"f. In paragraph 8, third line, amend \"f\" to read \"f/min\". Flashpoint is the temperature in degrees Celsius at which a product will give off.\nFlash point less than 73°F and boiling point less than 1QO°F. 3 Fp less -than C IP I6F ( to F) F F F F F F F F F. UJ Temperature [Degrees Celsius) Figure .. L/D = , F = , where L/D is the length-to-diameter ratio of the vent line) in reactor during relief, m3/sec M = mass of liquid in vessel, kg pf-liquid density, Flammable: A \"flammable liquid\" is defined as a liquid with a flash point. three-digit field on the FM display if the Celsius temperature -Fp. OOM . -____. RE CLOCK TIMER-TYPE. EXIT}. 2. Move the cursor to CLOCK, press ENTER .. A WARNING: The flash point of Type R solvent is °F ” F. Products 13 - 38 Two common scales of temperature are in use today, the centigrade and the Fahrenheit. holds for any process obeying the law PF»»C HowAs 0 divided ever, to a theoretical engine at a temperature of F with the theoretical The pipe line contains a little oil having a flash point of F A valve.", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/cdc25c-antibody-e302-hrp-ab205734.html", "date": "2019-10-23T10:30:00Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-43/segments/1570987833089.90/warc/CC-MAIN-20191023094558-20191023122058-00370.warc.gz", "language_score": 0.7634936571121216, "token_count": 714, "dump": "CC-MAIN-2019-43", "global_id": "webtext-fineweb__CC-MAIN-2019-43__0__78669234", "lang": "en", "text": "Product nameAnti-Cdc25C antibody [E302] (HRP)\nSee all Cdc25C primary antibodies\nDescriptionRabbit monoclonal [E302] to Cdc25C (HRP)\nTested applicationsSuitable for: WBmore details\nSpecies reactivityReacts with: Human\nPredicted to work with: Rat\nSynthetic peptide within Human Cdc25C (N terminal). The exact sequence is proprietary.\nDatabase link: P30307\n- WB: HeLa and wild-type HAP1 whole cell lysates.\nStorage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C. Stable for 12 months at -20°C. Store In the Dark.\nStorage bufferpH: 7.4\nPreservative: 0.1% Proclin\nConstituents: PBS, 30% Glycerol, 1% BSA\nConcentration information loading...\nPurityProtein A purified\nOur Abpromise guarantee covers the use of ab205734 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\n|WB||1/2500. Detects a band of approximately 60 kDa (predicted molecular weight: 53 kDa).|\nFunctionFunctions as a dosage-dependent inducer in mitotic control. It is a tyrosine protein phosphatase required for progression of the cell cycle. It directly dephosphorylates CDK1 and activate its kinase activity.\nSequence similaritiesBelongs to the MPI phosphatase family.\nContains 1 rhodanese domain.\nDevelopmental stageExpressed predominantly in G2 phase.\nmodificationsPhosphorylated by CHK1 on Ser-216. This phosphorylation creates a binding site for 14-3-3 protein and inhibits the phosphatase. Phosphorylated by PLK4.\n- Information by UniProt\n- CDC 25 antibody\n- Cdc 25C antibody\n- CDC25 antibody\nAll lanes : Anti-Cdc25C antibody [E302] (HRP) (ab205734) at 1/2500 dilution\nLane 1 :\nHeLa whole cell lysate (ab150035) at 10 µg\nLane 2 : Wild-type HAP1 cell lysate at 20 µg\nLane 3 : Cdc25C knockout HAP1 cell lysate at 20 µg\nDeveloped using the ECL technique.\nPerformed under reducing conditions.\nPredicted band size: 53 kDa\nObserved band size: 60 kDa why is the actual band size different from the predicted?\nExposure time: 16 minutes\nThis blot was produced using a 4-12% Bis-tris gel under the MOPS buffer system. The gel was run at 200V for 50 minutes before being transferred onto a Nitrocellulose membrane at 30V for 70 minutes. The membrane was then blocked for an hour using 3% milk before being incubated with ab205734 overnight at 4°C. Antibody binding was visualised using ECL development solution ab133406.\nab205734 has not yet been referenced specifically in any publications.", "domain": "chemistry", "round": 3} +{"url": "http://cpsm.kpi.ua/polymer-journal/1993/4771-polymer-blends-of-poly-p-phenylene-1-3-4-oxadiazole-and-poly-p-phenylene-terephthalamide-morphology-and-mechanical-behaviour.html", "date": "2018-03-24T23:46:34Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-13/segments/1521257651465.90/warc/CC-MAIN-20180324225928-20180325005928-00698.warc.gz", "language_score": 0.8547656536102295, "token_count": 303, "dump": "CC-MAIN-2018-13", "global_id": "webtext-fineweb__CC-MAIN-2018-13__0__216974908", "lang": "en", "text": "Film specimens and blend fibres of poly(p-phenylene 1,3,4-oxadiazole) (p-PODZ) and poly(p-phenylene terephthalamide) (PPTA) have been prepared. Morphologies were studied by optical and electron microscopy. Transparent films could be coagulated from ternary solutions under conditions that prevent large-scale phase separation while morphologies change in blend fibres with composition. A fibril matrix morphology is formed at low PPTA contents. Co-continuous morphologies result when the PPTA fraction increases and, finally, p-PODZ is spherically dispersed in PPTA. The mechanical behaviour has been examined using stress-strain and drawing experiments. The modulus of elasticity increases strongly when small amounts of PPTA are added to p-PODZ. The results are discussed in terms of the Halpin-Tsai model.\nПосилання на статтю:\nPolymer blends of poly(p-phenylene 1,3,4-oxadiazole) and poly(p-phenylene terephthalamide): morphology and mechanical behaviour / C. Kummerlowe and H. W. Kammer* and M. Malinconico and E. Martuscelli // Polymer. – 1993. – Vol 34. – P. 1677-1683.", "domain": "chemistry", "round": 3} +{"url": "https://link.springer.com/article/10.1007%2Fs12250-011-3194-9", "date": "2017-07-24T18:56:59Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-30/segments/1500549424909.50/warc/CC-MAIN-20170724182233-20170724202233-00027.warc.gz", "language_score": 0.9573893547058105, "token_count": 265, "dump": "CC-MAIN-2017-30", "global_id": "webtext-fineweb__CC-MAIN-2017-30__0__165369290", "lang": "en", "text": "Characterization of the receptor-binding domain of Ebola glycoprotein in viral entry\n- First Online:\n- 707 Downloads\nEbola virus infection causes severe hemorrhagic fever in human and non-human primates with high mortality. Viral entry/infection is initiated by binding of glycoprotein GP protein on Ebola virion to host cells, followed by fusion of virus-cell membrane also mediated by GP. Using an human immunodeficiency virus (HIV)-based pseudotyping system, the roles of 41 Ebola GP1 residues in the receptor-binding domain in viral entry were studied by alanine scanning substitutions. We identified that four residues appear to be involved in protein folding/structure and four residues are important for viral entry. An improved entry interference assay was developed and used to study the role of these residues that are important for viral entry. It was found that R64 and K95 are involved in receptor binding. In contrast, some residues such as I170 are important for viral entry, but do not play a major role in receptor binding as indicated by entry interference assay and/or protein binding data, suggesting that these residues are involved in post-binding steps of viral entry. Furthermore, our results also suggested that Ebola and Marburg viruses share a common cellular molecule for entry.", "domain": "chemistry", "round": 3} +{"url": "https://www.precision-camera.com/sony-np-fz100-li-ion-battery/", "date": "2023-05-29T18:06:28Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-23/segments/1685224644907.31/warc/CC-MAIN-20230529173312-20230529203312-00673.warc.gz", "language_score": 0.7861794233322144, "token_count": 254, "dump": "CC-MAIN-2023-23", "global_id": "webtext-fineweb__CC-MAIN-2023-23__0__7489736", "lang": "en", "text": "Sony NP-FZ100 Rechargeable Lithium-Ion Battery- 2280mAh\nThe Sony NP-FZ100 Rechargeable Lithium-Ion Battery is a high-capacity Z-series power source for select digital cameras. This battery is approximately 2.2x the capacity of the NP-FW50 W-series battery and supports InfoLITHIUM technology, which displays the remaining charge of the battery on the camera's LCD screen.\n- For a9, a7R III, and a7 III Cameras\n- High Capacity Electrical Capacity of 16.4Wh For Long Life\n- infoLITHIUM Makes it Possible to View the Remaining Power as Both a Percentange and Display and 5-step Indication on the Cameras LCD Screen\n- 2280 mAh\n- Output Voltage:\n- 7.2 V\n- 1.5 x 0.9 x 2.0\"\n- 2.9 oz\nIn The Box\n- Sony NP-FZ100 Lithium-Ion Rechargeable Battery\n- Sony 1 Year Limited Warranty", "domain": "chemistry", "round": 3} +{"url": "https://insights.ovid.com/jebot/201667140/00009810-201667140-00012", "date": "2019-01-23T03:45:13Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-04/segments/1547583884996.76/warc/CC-MAIN-20190123023710-20190123045710-00574.warc.gz", "language_score": 0.9436321258544922, "token_count": 426, "dump": "CC-MAIN-2019-04", "global_id": "webtext-fineweb__CC-MAIN-2019-04__0__68254943", "lang": "en", "text": "Stylo (Stylosanthes spp.) is a pasture legume predominant in tropical and subtropical areas, where low phosphorus (P) availability is a major constraint for plant growth. Therefore, stylo might exhibit superior utilization of the P pool on acid soils, particularly organic P. However, little is known about mechanisms of inorganic phosphate (Pi) acquisition employed by stylo. In this study, the utilization of extracellular deoxy-ribonucleotide triphosphate (dNTP) and the underlying physiological and molecular mechanisms were examined for two stylo genotypes with contrasting P efficiency. Results showed that the P-efficient genotype, TPRC2001-1, was superior to the P-inefficient genotype, Fine-stem, when using dNTP as the sole P source. This was reflected by a higher dry weight and total P content for TPRC2001-1 than for Fine-stem, which was correlated with higher root-associated acid phosphatase (APase) activities in TPRC2001-1 under low P conditions. Subsequently, three PAP members were cloned from TPRC2001-1: SgPAP7, SgPAP10, and SgPAP26. Expression levels of these three SgPAPs were up-regulated by Pi starvation in stylo roots. Furthermore, there was a higher abundance of transcripts of SgPAP7 and SgPAP10 in TPRC2001-1 than in Fine-stem. Subcellular localization analysis demonstrated that these three SgPAPs were localized on the plasma membrane. Overexpression of these three SgPAPs could result in significantly increased root-associated APase activities, and thus extracellular dNTP utilization in bean hairy roots. Taken together, the results herein suggest that SgPAP7, SgPAP10, and SgPAP26 may differentially contribute to root-associated APase activities, and thus control extracellular dNTP utilization in stylo.", "domain": "chemistry", "round": 3} +{"url": "http://www.birdsoutsidemywindow.org/2010/07/06/bad-news-for-people-who-breathe/", "date": "2017-10-22T00:53:34Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-43/segments/1508187824931.84/warc/CC-MAIN-20171022003552-20171022023552-00134.warc.gz", "language_score": 0.9580403566360474, "token_count": 316, "dump": "CC-MAIN-2017-43", "global_id": "webtext-fineweb__CC-MAIN-2017-43__0__66465679", "lang": "en", "text": "If you're not feeling well during this weather it's not just the heat, it's the air.\nBright sunshine and temperatures over 90 have brewed up some really bad air quality.\nShown above is our National Weather Service \"1-hour average\" ozone forecast for 5:00pm today. Red means unhealthy air and as you can see it's not confined to cities.\nOzone is cosmopolitan because it's formed in the sky and blows with the wind. It's created when heat and sunlight cause nitrous oxides (NOx) and volatile organic compounds (VOCs) to chemically combine into O3. NOx and VOCs come from motor vehicles, power plants, industry and chemical emissions and from those new gas well compressor stations popping up in Pennsylvania. That's why we're urged not to drive so much and to use less electricity on Ozone Action Days.\nWe're also told to stay indoors. That may work for us but it doesn't help birds, animals and plants that have nowhere else to go. Ozone is harmful to their respiratory systems, too, and it burns sensitive plants.\nSo we're all limiting our activity today - a sort of Ozone Inaction Day - and waiting for the weather to change.\nBad news for everything that breathes.\n(NOAA's 1-hour ozone prediction for the Eastern Great Lakes for 5:00pm July 6, 2010 (as of noon on July 5). Click on the image and the Loop Control arrow to watch the latest animation on the NOAA website.)", "domain": "chemistry", "round": 3} +{"url": "http://www.ozgeakbulut.com/", "date": "2022-09-27T04:58:34Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-40/segments/1664030334987.39/warc/CC-MAIN-20220927033539-20220927063539-00095.warc.gz", "language_score": 0.6762497425079346, "token_count": 2314, "dump": "CC-MAIN-2022-40", "global_id": "webtext-fineweb__CC-MAIN-2022-40__0__251216194", "lang": "en", "text": "Team- Burcin Ustbas, Post doctoral fellow\n- Ayse Ay, PhD candidate\n- Burak Ozbek, PhD candidate\n- Gizem Demir, PhD candidate\n- Isik Arel, PhD candidate\n- Madineh Rastgoo, PhD candidate\n- Aleyna Beste Mutlu, UG research assistant\nPartnersFarplas, ARYA, Inovent, SUCool\nAlumni- Buse Tatli, UG research assistant, now MSc candidate at EPFL\n- Tunahan Aytas, UG research assistant, now PhD candidate at MIT\n- Omid Akhlaghi, PhD, now post-doctoral fellow at the University College London\n- Amin Hodaei, MSc , now PhD candidate at EPFL\n- Gokay Avci, MSc , now PhD candidate Koc University\n- Pelin Guven, MSc, PhD from EPFL, now at Vironova, Sweden\nGungel, H., Menceloglu, Y., Yildiz, B. and Akbulut, O. “Fourier transform infrared and 1h nuclear magnetic resonance spectroscopic findings of silicone oil removed from eyes and the relationship of emulsification with retinotomy and glaucoma”, Retina, 25, 332–338 (2005).\nAkbulut, O., Taniguchi, I., Kumar, S., Shao-Horn, Y. and Mayes, A.M. “Conductivity hysteresis in polymer electrolytes incorporating poly(tetrahydrofuran)”, Electrochimica Acta, 52, 1983–1989 (2007).\nAkbulut, O., Jung, J.-M., Bennett, R.D., Hu, Y., Jung, H.-T. Cohen, R.E., Mayes, A.M. and Stellacci, F. “Application of supramolecular nanostamping to the replication of DNA nanoarrays”, Nano Letters, 7, 3493–3498 (2007).\nLiu, X., Yuan, J., Akbulut, O., Hu, J., Suib, S.L., Kong, J. and Stellacci, F. “Superwetting nanowire membranes or selective absorption”, Nature Nanotechnology, 3, 332–336 (2008).\nLaromaine, A.*, Akbulut, O.*, Stellacci, F. and Stevens, M. M. “Supramolecular replication of peptide and DNA patterned arrays”, Journal of Materials Chemistry, 20, 68–70 (2010).(*: equal contribution; cover article)\nAkbulut, O., Yu, A. A. and Stellacci F. “Fabrication of biomolecular devices via contact-based methods”, Chemical Society Reviews, 39, 30–37(2010).\nNie, Z., Deiss, F., Liu, X., Akbulut, O. and Whitesides, G. M. “Integration of paper-based microfluidic device with commercial elecrochemical readers”, Lab on a Chip, 10, 3163–3169 (2010).\nMace, C. R., Akbulut, O., Kumar, A. A., Shapiro, N. D., Derda, R., Patton, M. R. and Whitesides, G. M. “Aqueous multiphase systems of polymers and surfactants provide self-assembling gradients in density”, Journal of American Chemical Society, 134, 9094–9097 (2012).\nAkbulut, O., Mace, C. R., Martinez, R. V., Kumar, A. A., Nie, Z., Patton, M. R. and Whitesides, G. M. “Separation of nanoparticles in aqueous multiphase systems through centrifugation”, Nano Letters, 12, 4060–4064 (2012).\nAkhlaghi, O., Akbulut, O., and Menceloglu, Y. Z. “Extensional rheology and stability behavior of alumina suspensions in the presence of AMPS-modified poly(carboxylate ether)-based copolymers”, Colloid and Polymer Science, 293, 2867–2876 (2015).\nAkhlaghi, O., Akbulut, O., and Menceloglu, Y. Z. “Shear and extensional rheological characterization of poly(acrylonitrile)/halloysite nanocomposite solutions”, European Polymer Journal, 73, 17–25 (2015).\nBudak, E. P., Zirhli, O., Stokes, A. A., and Akbulut, O. “The Breathing Wall (BRALL)—Triggering life in(animate) surfaces”, Leonardo Transactions, 49 (2016).\nAvci, G., Akhlaghi, O., Ustbas, B., Ozbay, C., Menceloglu, Y. Z. and Akbulut,O. “A PCE-based rheology modifier allows machining of solid cast green bodies of alumina”, Ceramics International, 42, 3757–3761 (2016).\nAkbulut, O. “We should do what we do best in our usual ways”, Journal of Medical and Surgical Research, 2, 184–185 (2016).\nGuven, Z. P., Ustbas, B., Harkness, K. M., Coskun, H., Joshi, C. P., Besong, T. M. D, Stellacci, F., Bakr, O. M., and Akbulut, O. “Synthesis and characterization of mixed ligand chiral nanoclusters”, Dalton Transactions, 45, 12297–11300 (2016).\nAkhlaghi, O., Menceloglu, Y. Z., and Akbulut, O. “Shear and extensional rheological study of poly(acrylonitrile)-Sb2O3 nanocomposite solutions”, Colloid and Polymer Science, 294,\nKilic, D., Ustbas, B., Budak, E. P.,Eyisoylu, H., Yilmaz, C., Eldem, B., and Akbulut, O. “Silicone-based composites as surgical breast models for oncoplasty training”, Procedia Engineering, 159, 104–107 (2016).\nAkhlaghi, O., Menceloglu, Y. Z., and Akbulut, O. “Poly(carboxylate ether)-based superplasticizer achieves workability retention in calcium aluminate cement”, Scientific Reports, 7 (2017).\nAkhlaghi, O., Hodaei, A., Sezer, D., Aytas, T., Tatli, B., Rosine, F. A., Scrivener, K., Menceloglu, Y. Z., and Akbulut, O. “Modified poly(carboxylate ether)-based superplasticizer enhances flowability of calcined clay-limestone-gypsum blended cement”, Cement and Concrete Research, 101, 114–122 (2017).\nUstbas, B., Kilic, D., Bozkurt, A., Aribal, M. E., and Akbulut, O. “Silicone-based composite materials simulate breast tissue to be used as ultrasonography training phantoms”, Ultrasonics, 88, 9–15 (2018).\nHodaei, A., Akhlaghi, O., Khani, N., Aytas, T, Sezer, D., Tatli, B., Menceloglu, Y. Z., Koc, B., and Akbulut, O. “Single additive enables 3D printing of highly-loaded iron oxide suspensions”, ACS Applied Materials and Interfaces, 9873–9881 (2018).\nPublications basliginin altina da su makaleleri ekleyelim lutfen: Ustbas Gul, B., Kilic Yanilmaz, D., Arslan, D., Bayramicli, M., and Akbulut, O. “Silicone-based simulation models for peripheral nerve microsurgery”, Journal of Plastic, Reconstructive & Aesthetic Surgery 72, 477–483 (2019).\nGoharibajestani, Z., Akhlaghi, O., Akaoglu, C., Afghah, F., Khani, N., Hodaei, A., Koc, B., and Akbulut, O. “Incorporating steric hindrance into the additive design enables a robust formulation of alumina ink for extrusion-based 3D printing”, ACS Applied Polymer Materials 1, 3279–3285 (2019).\nWO/2012/024688 (HU3865) - Multiphase systems and uses thereof - Inventors: Charles R. Mace, Ozge Akbulut Halatci, Ashok A. Kumar, Nathan D. Shapiro, and George M. Whitesides. (Publication date: February, 23, 2012\nWO/2012/024690 (HU4262) - Multiphase systems having multiple phase properties - Inventors: Ozge Akbulut Halatci, Charles R. Mace, Ashok A. Kumar, Zhihong Nie, and George M. Whitesides. (Publication date: February, 23, 2012)\nWO/2012/024691 (HU4263) - Multiphase systems for analysis of solid materials - Inventors: Charles R. Mace, Ozge Akbulut Halatci, Ashok A. Kumar, Nathan D. Shapiro, and George M. Whitesides. (Publication date: February, 23, 2012)\nUS20120302456 A1 (HU3985) - A vertical flow-through device for multiplexed ELISA driven by wicking-Inventors: Max Narovlyansky, Ozge Akbulut Halatci, Charles R. Mace, and George M. Whitesides. (Publication date: November, 11, 2012)\nEP15155210.6 - An additive for suspensions- Inventors: Omid Akhlaghi, Ozge Akbulut, and Yusuf Z. Menceloglu. (Publication date: August, 18, 2016)", "domain": "chemistry", "round": 3} +{"url": "https://www.semanticscholar.org/paper/Differential-Effects-of-Sunitinib-on-the-Expressio-Korashy-Ansari/fefb57bffdd0e6c2f0cb90fc2be16fcea8bfa471", "date": "2017-12-15T04:18:55Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-51/segments/1512948563629.48/warc/CC-MAIN-20171215040629-20171215060629-00690.warc.gz", "language_score": 0.9555113315582275, "token_count": 403, "dump": "CC-MAIN-2017-51", "global_id": "webtext-fineweb__CC-MAIN-2017-51__0__87727558", "lang": "en", "text": "Sunitinib (SUN) is a multi-targeted tyrosine kinase inhibitor that was recently approved for the treatment of gastrointestinal tract and renal cancers. To date, very little is known about the effects of SUN on the expression of hepatic and renal xenobiotic-metabolizing enzymes (XMEs) and transporters. The present study was designed to investigate the capacity of chronic SUN treatment to modulate the mRNA and protein expression levels of phase I cytochrome P450 (CYP), phase II conjugating enzymes, and phase III transporters in rat liver and kidneys. For this purpose, SUN (25, 50 and 100 mg/kg) was injected IP into Wistar albino rats for 4 weeks; thereafter, the mRNA and protein expression levels of several XMEs and transporters were determined by RT-PCR and Western blot analysis, respectively. Real-time PCR analysis showed that SUN significantly induced the hepatic and renal CYP1A1, 1A2, 1B1, 2E1 and 4F4, whereas it inhibited CYP2C11 and 4A2. Furthermore, SUN specifically induced renal, but not hepatic, CYP2J3 and 3A2, while it induced only hepatic CYP4A1. With regard to phase II, SUN induced hepatic GSTA1 and UGT1A and renal NQO1 and UGT1A mRNA levels, whereas it inhibited renal GST1A expression. On the other hand, both renal and hepatic P-gp, MRP2 and BCRP transporters were significantly induced by SUN at the mRNA and protein expression levels. Importantly, these differential effects were associated with changes in oxidative stress genes and lipid peroxidation levels. In conclusion, SUN can serve as XME and transporters modulator, which potentially may counteract the efficacy of the treatment, adverse reactions and drug interactions in SUN treatment.", "domain": "chemistry", "round": 3} +{"url": "https://studylib.net/doc/25225528/chapter-4", "date": "2020-11-26T21:50:36Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-50/segments/1606141188947.19/warc/CC-MAIN-20201126200910-20201126230910-00089.warc.gz", "language_score": 0.9191728234291077, "token_count": 259, "dump": "CC-MAIN-2020-50", "global_id": "webtext-fineweb__CC-MAIN-2020-50__0__89922722", "lang": "en", "text": "CHAPTER 4 Introducing Earth LESSON 1 The Earth System THE EARTH AS A SYSTEM The Earth system involves a constant flow of matter through different parts. The constant flow, or cycling, of matter through the earth system is driven by energy. Energy is the ability to do work. The energy that drives the Earth system has two main sources: heat from the sun and heat flowing out of Earth as it cools. PARTS OF THE EARTH SYSTEM The Earth contains air, water, land and life. Each of these forms its own “sphere.” Atmosphere Hydrosphere Geosphere Biosphere ATMOSPHERE The Earth’s outermost layer is a mixture of gasses. Primarily nitrogen (78%), oxygen (21%), and argon (1%). Trace amounts of carbon dioxide, neon, helium, methane, krypton, hydrogen, nitrous oxide, xenon, ozone, iodine, and carbon monoxide. Lower altitudes also have quantities of water vapor. The atmosphere we have today is very different from the Earth’s early atmosphere. When the planet first cooled down 4.4 billion years ago, volcanos spewed out steam, carbon dioxide and ammonia, and it was 100 times as dense as today’s atmosphere.", "domain": "chemistry", "round": 3} +{"url": "https://meridian.allenpress.com/corrosion/article-abstract/78/11/1117/487377/In-Situ-Investigation-of-Hydrogen-Induced-Cracking", "date": "2022-12-01T06:16:25Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-49/segments/1669446710801.42/warc/CC-MAIN-20221201053355-20221201083355-00201.warc.gz", "language_score": 0.8969149589538574, "token_count": 383, "dump": "CC-MAIN-2022-49", "global_id": "webtext-fineweb__CC-MAIN-2022-49__0__257457565", "lang": "en", "text": "NACE MR0175/ISO 15156 provides the severity of a sour environment defined as a function of pH and H2S partial pressure for sulfide stress cracking. Although hydrogen-induced cracking (HIC) is also a major issue of linepipes exposed to a sour environment, the severity diagram does not necessarily correspond to the HIC susceptibility. Recently, from the viewpoint of fitness-of-purpose, the severity diagrams for HIC have been proposed based on the concept of equal hydrogen concentration. From this concept, HIC susceptibility corresponds well to the steady-state hydrogen permeability obtained from the hydrogen permeation test method. In this study, in order to clarify the relationship between HIC susceptibility and hydrogen diffusion behavior, in situ crack inspection during the HIC test and finite element method analysis of hydrogen diffusion were performed. The in situ inspection technique using phased-array ultrasonic testing which can capture the time dependence of crack distribution, and HIC initiation and propagation behaviors were clearly visualized and investigated. It was found that crack initiation and propagation stabilize as hydrogen concentration reaches a steady-state value throughout the specimen and the result was considered evidence that the HIC susceptibility corresponded with the steady value of hydrogen permeability.\nIn Situ Investigation of Hydrogen-Induced Cracking Behavior in Linepipe Steel Under Different Environments\n- Views Icon Views\n- Share Icon Share\n- Search Site\nKyono Yasuda, Nobuyuki Ishikawa, Taishi Fujishiro, Takuya Hara, Eiji Tada, Mitsuo Kimura; In Situ Investigation of Hydrogen-Induced Cracking Behavior in Linepipe Steel Under Different Environments. CORROSION 1 November 2022; 78 (11): 1117–1125. doi: https://doi.org/10.5006/4069\nDownload citation file:", "domain": "chemistry", "round": 3} +{"url": "http://www.nanoarchive.org/3537/", "date": "2014-11-24T06:39:02Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2014-49/segments/1416400380409.19/warc/CC-MAIN-20141119123300-00194-ip-10-235-23-156.ec2.internal.warc.gz", "language_score": 0.7336747646331787, "token_count": 347, "dump": "CC-MAIN-2014-49", "global_id": "webtext-fineweb__CC-MAIN-2014-49__0__70937664", "lang": "en", "text": "Sundararaian, Sri Priya and Grady, Nathaniel K. and Mirin, Nikolay and Halas, Naomi J. (2008) Nanoparticle-induced enhancement and suppression of photocurrent in a silicon photodiode. NANO LETTERS, 8 (2). pp. 624-630.\nFull text is not hosted in this archive but may be available via the Official URL, or by requesting a copy from the corresponding author.\nOfficial URL: http://pubs.acs.org/doi/abs/10.1021/nl073030%2B\nNanoparticles are capable of both enhancing and suppressing the photocurrent in a silicon diode when deposited on the active face of the device. Photocurrent imaging of the individual nanoparticles and nanoparticle aggregates responsible for this effect reveals that Au nanospheres, nanoshells, and nanoshell dimers each exhibit unique wavelength-dependent suppression-enhancement characteristics. In contrast, silica nanospheres provide a sizable and relatively uniform photocurrent enhancement across the same spectral range, (532-980 nm). Unusual light-harvesting behavior observed correlates with a highly complex energy flow (optical ``vortexing'') for the forward scattered light, of plasmon resonant nanoparticles into the device.\n|Subjects:||Material Science > Functional and hybrid materials|\nPhysical Science > Photonics\n|Deposited By:||Farnush Anwar|\n|Deposited On:||16 Jan 2009 16:47|\n|Last Modified:||29 Jan 2009 11:44|\nRepository Staff Only: item control page", "domain": "chemistry", "round": 3} +{"url": "https://www.meagherspharmacy.ie/collections/75-100/products/lancome-idole-lintense-eau-de-parfum", "date": "2023-06-06T00:26:27Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-23/segments/1685224652184.68/warc/CC-MAIN-20230605221713-20230606011713-00169.warc.gz", "language_score": 0.8356778621673584, "token_count": 547, "dump": "CC-MAIN-2023-23", "global_id": "webtext-fineweb__CC-MAIN-2023-23__0__212582744", "lang": "en", "text": "True to the signature of Idôle Le Parfum, Idôle L’Intense is a fragrance with a stronger-than-ever addictive clean accord at its core, and a flamboyant Floral heart wrapped in a vibrant chypre accord and a sensual vanilla. A radiant and flamboyant rose and a kaleidoscope of jasmine, making it the best perfume for a glowier sensation on the skin.\nThe sharp & dynamic silhouette of the perfume Idôle is designed to fuse naturally with the hand, allowing for a seamless & delightful application. Idôle L’Intense is a fragrance like a flame, sharp and radical with an incandescent heart.\nA burning flame thanks to the gold intensity covering the edges and the back of the fragrance bottle. A burning fragrance through the glass transparency revealing the most brilliant version of the Idôle woman.\nNotes: Vanilla, Rose, Jasmine.\nHold 3-6 inches away and spray onto pulse points.\nAlcohol, Parfum / Fragrance, Aqua / Water / Eau, Benzyl Salicylate, Benzyl Alcohol, Hydroxycitronellal, Ethylhexyl Salicylate, Butyl Methoxydibenzoylmethane, Hexyl Cinnamal, Linalool, Limonene, Citronellol, Alpha-Isomethyl Ionone, Coumarin, Benzyl Benzoate, Farnesol, Geraniol, Methyl Anthranilate, Tris(Tetramethylhydroxypiperidinol) Citrate, Citral, Eugenol, Ci 14700 / Red 4, Ci 60730 / Ext. Violet 2.\nYou added Lancôme Idôle L'Intense Eau de Parfum to your cart.\nThe Vital Role of Iron in a Healthy PregnancyRead now\nLow iron is one of the most common nutritional deficiencies during pregnancy, and it can lead to various adverse outcomes for both the mother and the baby. Therefore, it is crucial for women to ensure they are meeting their daily iron requirements through a balanced diet and prenatal supplements.\nIron Deficiency and SupplementationIron is a super important mineral that plays a critical role in a variety of our body functions, such as the creation of haemoglobin, which transports oxygen throughout the body. When iron levels in the body are low, it can lead to a range of health issues and symptoms that may affect your day to day life.Read now", "domain": "chemistry", "round": 3} +{"url": "https://www.rcsb.org/ligand/STI", "date": "2022-12-09T15:06:08Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-49/segments/1669446711417.46/warc/CC-MAIN-20221209144722-20221209174722-00376.warc.gz", "language_score": 0.8577299118041992, "token_count": 259, "dump": "CC-MAIN-2022-49", "global_id": "webtext-fineweb__CC-MAIN-2022-49__0__175055806", "lang": "en", "text": "Imatinib is a small molecule kinase inhibitor used to treat certain types of cancer. It is currently marketed by Novartis as Gleevec (USA) or Glivec (Europe/Australia) as its mesylate salt, imatinib mesilate (INN). It is occasionally referred to as CGP57148B or STI571 (especially in older publications). It is used in treating chronic myelogenous leukemia (CML), gastrointestinal stromal tumors (GISTs) and a number of other malignancies. It is the first member of a new class of agents that act by inhibiting particular tyrosine kinase enzymes, instead of non-specifically inhibiting rapidly dividing cells.\nDrug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison\nT, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS.\nNucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682", "domain": "chemistry", "round": 3} +{"url": "https://vector-center.com/tracking-the-pfas-threat/", "date": "2022-09-28T08:59:43Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-40/segments/1664030335190.45/warc/CC-MAIN-20220928082743-20220928112743-00693.warc.gz", "language_score": 0.9667315483093262, "token_count": 1008, "dump": "CC-MAIN-2022-40", "global_id": "webtext-fineweb__CC-MAIN-2022-40__0__85167147", "lang": "en", "text": "- The city and residents of Newburgh, New York have known about PFAS contamination in their water since 2014 from Stewart Air National Guard Base among other potential sources, but are still waiting for a formal cleanup plan from various federal agencies.\n- In communities across the United States, PFAS contamination from Department of Defense (DoD) sites has been found at at least 126 bases or former bases and installations; the DoD says there are potentially 401 total sites where PFAS contamination may be present.\n- The DoD’s response to the crisis has varied from community to community, and a little less than half of the news coverage about the DoD’s response has been negative, while only about 20% of coverage has been positive.\nGroundwater and surface water contamination from Per- and polyfluoroalkyl substances (PFAS) is emerging as a key threat to drinking water safety\nAcross the United States, a seemingly slow moving water contamination crisis is emerging. Per- and polyfluoroalkyl substances (PFAS) widely used in manufacturing for their “non-stick” properties and by the military and aviation sectors for their fire-fighting abilities have been building up in the nation’s water supplies.\nWhile their usage has slowed in recent years, after an EPA health advisory back in 2016, these persistent chemicals remain in water sources, and are particularly prevalent around military and air force bases where firefighting drills were common.\nIn communities like Newburgh, New York, PFAS was detected as early as 2014 in drinking water sources due in part to runoff from the Stewart Air National Guard Base, leading to the community declaring a state of emergency in 2016. But this state of emergency was quickly reversed by the City Manager Michael G. Ciaravino, leaving the community uncertain about the safety of their drinking water.\nSince, the DoD response has been slow moving, leaving communities like Newburgh uncertain how to proceed, and it is often unclear just how safe or unsafe their drinking water is.\nIn November 2018, the DoD sent a team to Newburgh to speak with local residents, directly addressing the community’s concerns for the first time. Their message was clear, “We want to get the water clean. And we’re here to do that,” John Henderson, assistant secretary of the Air Force for Installations, Environment and Energy told the attendees. But to local communities members their response was too little, too late.\nIn a dramatic moment, thirteen year Newburgh resident Beatrice Harris described the health problems her and her partner have suffered, she believes in part due to chemicals from the military base. “I had faith in the federal government once upon a time. It’s gonna take a hole lot more than shiny promises to fix that damage,” she told the DoD representatives.\nThis loss of faith in both the DoD and the Federal Government concerning water safety and the protection of the communities where the military operates, will have long term consequences for both current clean up efforts and future collaborations between the military and local municipalities.\nPFAS water contamination is not well understood in all areas where the threat of contamination is high\nPFAS Facts, From Content Partner Circle of Blue:\n- Per- and polyfluoroalkyl substances (PFAS) are a class of over 3,500 man made chemicals that were developed after the second World War. Since then, PFAS have been incorporated into a range of products: firefighting foam, non-stick skillets, water-repelling jackets, stain-resistant carpets, floor cleaners, waxes, paints, insect traps, and more.\n- Perfluorinated compounds, a subgroup of PFAS, are extremely persistent in the environment. They have been called “forever chemicals” because the carbon-fluorine bond that holds the molecules together is the strongest chemical bond. Additionally, some PFAS compounds, particularly perfluoroalkyl acids, are both mobile and bio-cumulative. This means they move quickly in groundwater, as well as build up in organisms faster than they are excreted.\n- In addition to industrial production facilities, contaminated sites in the U.S. include military bases, fire stations, landfills, hospitals, and schools. All of these large institutions use foams or waxes or cleaners that contain the chemicals.\n- The U.S. Department of Defense counts more than 400 active or closed bases with a known or suspected release of PFAS. The military has spent more than $210 million on cleanup so far.\n- In May 2016, the U.S. Environmental Protection Agency lowered its health advisory for two PFAS chemicals, PFOA and PFOS, to 70 parts per trillion in drinking water. The health advisory is not binding, and some public health researchers argue that it ought to be even lower.", "domain": "chemistry", "round": 3} +{"url": "https://www.iciq.org/professors-melchiorre-and-perez-awarded-by-the-rseq/", "date": "2023-09-30T00:31:36Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233510529.8/warc/CC-MAIN-20230929222230-20230930012230-00548.warc.gz", "language_score": 0.9421372413635254, "token_count": 333, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__232456126", "lang": "en", "text": "Prof. Paolo Melchiorre has been awarded with the Premio a la Excelencia Investigadora RSEQ 2016 for the impact and international leadership of his research in organocatalysis. In particular, for the innovative nature of his studies with primary amines based on quinine, and the originality of its recent developments combining the fields of organocatalysis and photochemistry.\nProf. Melchiorre joined ICIQ in 2009 as group leader and ICREA Research Professor. In 2011, he received and ERC Starting Grant for the project “ORGA-NAUT: Exploring Chemical Reactivity with Organocatalysis”, while in 2016 he has been awarded an ERC Consolidator Grant to carry out the project “CATA-LUX: Light-Driven Asymmetric Organocatalysis”\nProf. Pedro J. Pérez, member of the ICIQ’s Scientific Advisory Board, has received the Medalla de Oro de la RSEQ 2016 in recognition of the uniqueness, relevance and visibility of his achievements in the field of homogeneous catalysis and its impact on chemical activation of unactivated C-H bonds of hydrocarbons, forming a track record of excellence in a complex and extremely competitive area.\nProf. Pérez works as full Professor and head of Center for Research in Sustainable Chemistry at the University of Huelva. His research interests are the development of homogeneous catalysts for the functionalization of hydrocarbons by transfer reactions from metal centers. In the last years, he is particularly focussed in alkanes as substrates.", "domain": "chemistry", "round": 3} +{"url": "https://www.usgs.gov/publications/roles-saltcedar-tamarix-spp-and-capillary-rise-salinizing-non-flooding-terrace-flow-0", "date": "2022-07-04T04:04:39Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-27/segments/1656104293758.72/warc/CC-MAIN-20220704015700-20220704045700-00279.warc.gz", "language_score": 0.8860834836959839, "token_count": 457, "dump": "CC-MAIN-2022-27", "global_id": "webtext-fineweb__CC-MAIN-2022-27__0__169652079", "lang": "en", "text": "Tamarix spp. (saltcedar) secretes salts and has been considered to be a major factor contributing to the salinization of river terraces in western US riparian zones. However, salinization can also occur from the capillary rise of salts from the aquifer into the vadose zone. We investigated the roles of saltcedar and physical factors in salinizing the soil profile of a non-flooding terrace at sites on the Cibola National Wildlife Refuge on the Lower Colorado River, USA. We placed salt traps under and between saltcedar shrubs and estimated the annual deposition rate of salts from saltcedar. These were then compared to the quantities and distribution on of salts in the soil profile. Dense stands of saltcedar deposited 0.159 kg m−2 yr−1 of salts to the soil surface. If this rate was constant since seasonal flooding ceased in 1938 and all of the salts were retained in the soil profile, they could account for 11.4 kg m−2 of salt, about 30% of total salts in the profile today. Eliminating saltcedar would not necessarily reduce salts, because vegetation reduces the upward migration of salts in bulk flow from the aquifer. The densest saltcedar stand had the lowest salt levels in the vadose zone in this study.\n|Title||Roles of saltcedar (Tamarix spp.) and capillary rise in salinizing a non-flooding terrace on a flow-regulated desert river|\n|Authors||E.P. Glenn, K. Morino, Pamela L. Nagler, R.S. Murray, S. Pearlstein, K.R. Hultine|\n|Publication Subtype||Journal Article|\n|Series Title||Journal of Arid Environments|\n|Record Source||USGS Publications Warehouse|\n|USGS Organization||Southwest Biological Science Center|", "domain": "chemistry", "round": 3} +{"url": "https://www.plantedtank.net/forums/29-substrate/3537-bad-gas-sand.html", "date": "2020-04-02T11:57:40Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-16/segments/1585370506959.34/warc/CC-MAIN-20200402111815-20200402141815-00092.warc.gz", "language_score": 0.9553093314170837, "token_count": 319, "dump": "CC-MAIN-2020-16", "global_id": "webtext-fineweb__CC-MAIN-2020-16__0__177842895", "lang": "en", "text": "I don't know that this applies to sand. Lots of folks here use sand as a component of their substrate to great effect. ...\nWhat can sometimes \"poison\" a tank is if there is a space where \"anerobic\" (without oxygen) bacteria growth can take place. There are both \"good\" and \"bad\" bacteria than can only survive in a place with no oxygen. I don't remember the names of the organisms.\nOne \"good\" anerobic bacteria is a species people without planted tanks try to cultivate in an apparatus called a \"denitrator\". Many people have had horrid experiences with these devices - others think they're wonderful. Denitrators try to make anerobic conditions in a very slow flow of water from the tank to grow this \"good\" bacteria. This little guy processes nitrate into nitrogen gas - removing nitrate from the aquarium. A much simpler way to remove nitrate from the aquarium is to do partial water changes.\nA \"bad\" anerobic bacteria makes the \"rotten egg\" smelling gas that can poison a tank.\nBoth can grow in an anerobic environment.\nI suspect the \"stir the sand\" recommendation is to get oxygenated water all through the substrate again, to prevent having anerobic conditions down in the substrate.\nWhat you want is a very small circulation of water in the substrate to help keep a little oxygen down in there.\nSome of the guys who use sand in their tanks can tell you what kind they use and what their experiences have been.", "domain": "chemistry", "round": 3} +{"url": "https://researchportal.vub.be/en/publications/new-development-in-radio-iodinated-radiopharmaceuticals-for-spect-2", "date": "2021-06-20T06:28:38Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-25/segments/1623487658814.62/warc/CC-MAIN-20210620054240-20210620084240-00393.warc.gz", "language_score": 0.9192383885383606, "token_count": 563, "dump": "CC-MAIN-2021-25", "global_id": "webtext-fineweb__CC-MAIN-2021-25__0__68314091", "lang": "en", "text": "[123/125I]-2-Iodo-L-phenylalanine and [123/125I]-2-Iodo-D-phenylalanine, with the radioiodine atom on the 2 position of the aromatic ring, were evaluated as potential specific tumour tracers for SPECT. The tracers were obtained with an overall radiochemical yield of at least 98% and a purity of > 99 % in one-pot Kit conditions. The tracers were evaluated in vitro using R1M rhabdomyosarcoma cells as cancer cell model. The initial uptake of [125I]-2-Iodo-D-phenylalanine is slower than that of the L analogue but up from 20 minutes the uptake as function of time is the same. The uptake of the D analogue is proven to occur by the same LAT transport system used by L amino acid and to be satiable resulting in a Km value of 32µM comparable with the L analogue. Although both compounds showed an apparent accumulation over 24 hours no incorporation was noticed. In vivo, the biodistribution of [123/125I]-2-Iodo- L and D-phenylalanine in R1M rhabdomyosarcoma bearing rats was measured by dynamic planar imaging (DPI) . [99mTc]-PP planar imaging was performed to correct for blood pool activity. [123I]-2-Iodo-D-phenylalanine showed a DUR value of 2.9 at 30 min p.i., while for [123I]-2-Iodo-L-phenylalanine, the DUR value reached 3.2. Blood clearance of the tracers occurred through the kidneys to the bladder resulting in low tracer activity in the abdomen. The activity in the brain was also low. Specific tumour uptake was confirmed using [99mTc]-PP and by displacement with L-Phe. In rats both tracers showed a high in vivo stability up to 2 hours p.i., almost no free radioiodide and no other labelled metabolites were observed. The characteristics of the biodistribution make [123I]-2-Iodo-L- and D-phenylalanine promising tumour specific tracers for SPECT. The long-term retention of the activity in the tumours coupled to a profound clearance from blood and tissue make these tracers candidate for radionuclide therapy with 131I.\n|Number of pages||10|\n|Journal||Trends in Radiopharmaceuticals ISTR 2005(IAEA), Volume 2: 223-32.|\n|Publication status||Published - 2005|\n- D-Amino acid", "domain": "chemistry", "round": 3} +{"url": "https://sipcotcuddalore.com/news_hindubusinessline_171110/", "date": "2024-04-12T13:52:39Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712296816024.45/warc/CC-MAIN-20240412132154-20240412162154-00414.warc.gz", "language_score": 0.9657062292098999, "token_count": 567, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__66086413", "lang": "en", "text": "Nov. 16, 2010\nHindu Business Line\nHUL admits to breach of protocol at TN factory World Economic Forum.\nNew Delhi: At the release of its global ‘Sustainable Living Plan’ programme at the World Economic Forum, Hindustan Unilever Ltd (HUL) admitted that it had committed a grievous breach of protocol at its mercury thermometer factory in Kodaikanal.\nBut nine years after the incident took place and the factory was shut down, the soil remediation at the premises is yet to be complete.\nThe reason why it is taking so long, according to HUL, a subsidiary of the Anglo-Dutch multinational corporation Unilever, is that there is disagreement between various bodies about what exactly has to be done.\n“Currently there are some issues about the level of remediation, not because we don’t want to do it but because there are different bodies that have to be agreed to what has to be done,” said Mr Harish Manwani, Chairman, HUL, adding that he did not want to comment further as the matter was sub judice.\nThe Tamil Nadu Pollution Control Board reportedly gave its consent for remediation work as early as in June 2008.\nThe incident was unearthed in 2001 when contaminated glass scrap from the factory was being sold in the locality in breach of protocol.\nThe mercury glass thermometer factory was set up at Kodaikanal by erstwhile Ponds India Ltd in 1983 for markets in US, Europe and South America.\nIt came under the management of HUL through acquisition in September 1998 and continued to be in operation till March 2001, when non-governmental organisations discovered the presence of mercury tainted glass scrap at a scrap yard in Kodaikanal and the factory was shut down.\nAround 5.3 tonnes of mercury tainted glass scrap (containing residual mercury of approximately 0.15 per cent) was sold in breach of the company’s established procedures.\nFrom March to May 2003, HUL exported around 290 tonnes of mercury bearing materials such as mercury-contained glass scrap, semi and finished thermometers, virgin mercury and ETP sludge to a mercury recycler in the US.\nSections of the media and NGOs such as Greenpeace have highlighted the extent of health and environmental hazards caused by remains of mercury scrap. But the company maintains that there has only been limited impact on the soil at some spots of the factory, which requires remediation. On the basis of a report prepared by M/s URS, HUL maintains that there is no adverse impact on the health of its workers or the surrounding environment. M/s URS is an international environmental consultant hired by HUL for site assessment and risk assessment.", "domain": "chemistry", "round": 3} +{"url": "https://rd.springer.com/chapter/10.1007/978-1-4899-0933-6_54", "date": "2018-09-21T04:29:10Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-39/segments/1537267156780.2/warc/CC-MAIN-20180921033529-20180921053929-00500.warc.gz", "language_score": 0.6551589965820312, "token_count": 482, "dump": "CC-MAIN-2018-39", "global_id": "webtext-fineweb__CC-MAIN-2018-39__0__41636936", "lang": "en", "text": "A Modified Noncontact Method for Critical Temperature Measurements of High Temperature Superconductors\nA significant breakthrough in the synthesis of high-Tc superconductors has been accomplished during the last three years.1 As large numbers of various experimental samples are produced, there is an increasing need for a rapid, non-contact method for their evaluation.\nKeywordsCopper Sample Superconducting Sample Calculated Resistivity Noncontact Method Bridge Response\nUnable to display preview. Download preview PDF.\n- 1.J. G. Bednorz and K. A. Muller, Z.Phys. B 64, 189 (1986); M. K. Wu, J. R. Ashburn, C. T. Torng, P. H. Hor, R. L. Meng, L. Gao, Z. J. Huang, Y. Q. Wang, and C. W. Chu, Phys.Rev.Lett. 58, 908 (1987); C. Michel, M. Hervien, M. M. Borel, A. Grandin, F. Deslandes, J. Provost, and B. Raveau, Z.Phys. B 68, 421 (1987); Z. Z. Sheng and M. A. Hermann, Nature 332, 138 (1988).Google Scholar\n- 2.L. J. van der Pauw: “Measurement of Sheet Resistivities with the Four-Point Probe”, Bell Syst. Techn. J. 411, 1958.Google Scholar\n- 4.J. D. Doss, D. W. Cooke, C. W. Mc Cabe, and M. A. Maez, Rev. Sci. Instrum. 59, 659 (1988); J. D. Doss, D. W. Cooke, P. N. Arendt, M. Nastasi, R. E. Muenchausen, and J. R. Tesmer, Supercond Sci. Technol. 2, 63 (1989).Google Scholar\n- 5.P. M.Nikolie, M. Miletié, M. B. Pavlovie, Z. B. Mariné, and D. I. Rakovid, Patent application P. 1286/89, Belgrade (Yugoslavia).Google Scholar", "domain": "chemistry", "round": 3} +{"url": "http://m.nacchemical.com/interferon-1b-3790814.html", "date": "2020-05-28T05:15:51Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-24/segments/1590347396495.25/warc/CC-MAIN-20200528030851-20200528060851-00274.warc.gz", "language_score": 0.7277637720108032, "token_count": 286, "dump": "CC-MAIN-2020-24", "global_id": "webtext-fineweb__CC-MAIN-2020-24__0__91565440", "lang": "en", "text": "Price And Quantity\n- 100 Onwards INR\n- 746.5 Grams (g)\n- This medication is used to treat various cancers (e.g., leukemia, melanoma, AIDS-related Kaposi's sarcoma). It is also used to treat virus infections (e.g., chronic hepatitis B, chronic hepatitis C, condylomata acuminata). This medication is the same as a protein that your body naturally produces (interferon).\n- °C), 61 °C\nEuropean Pharmacopoeia (EP) Reference Standard\n|Related Categories||Analytical Standards, Analytical/Chromatography, EP Standards, EP Standards I - K, Pharmacopeia & Metrological Institutes Standards|\n- Cash in Advance (CID), Cash Advance (CA)\n- 500 KG Per Month\n- 2-8 Week\n- Sample costs shipping and taxes has to be paid by the buyer\n- Carton and Poly Bag.\n- Africa, Middle East, Western Europe, Eastern Europe, South America, North America, Central America, Australia, Asia\n- All India\nKesarkunj, Room No. 9, 2 Nd Floor, Vasanji Lalji Road, Kandivali Station Road, Opp. Mcdonlad's, Near Jain Restaurant, Kandivali (West), Mumbai, Maharashtra, 400067, India", "domain": "chemistry", "round": 3} +{"url": "http://www.yeastgenome.org/reference/S000129074/overview", "date": "2014-07-12T12:42:21Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2014-23/segments/1404776432978.12/warc/CC-MAIN-20140707234032-00074-ip-10-180-212-248.ec2.internal.warc.gz", "language_score": 0.8290128111839294, "token_count": 666, "dump": "CC-MAIN-2014-23", "global_id": "webtext-fineweb__CC-MAIN-2014-23__0__22605192", "lang": "en", "text": "We have previously shown that Saccharomyces cereuisiae mitochondria contain a full set of mitochondrial DNA-coded isoaccepting tRNAs. We report here the presence of two lysine tRNA isoacceptors in purified yeast mitochondria, only one of which (tRNA2Lys) is of mitochondrial origin. The other mitochondria-associated lysine tRNA (tRNA1Lys) does not hybridize with mitochondrial DNA (mtDNA) and elutes with one of the cytoplasmic lysine tRNA isoacceptors in the RPC-5 column chromatographic system. This tRNA was purified by two-dimensional polyacrylamide gel electrophoresis of in vivo 32P-labeled total mitochondrial tRNA. Sequence analysis showed that it corresponds to cytoplasmic tRNALys (anticodon C-U-U), whose primary structure has already been determined by Smith and coworkers [Smith, C. J., Teh, H. s.,Ley, A., & D?Obrenan, P. (1973) J. Biol. Chem. 248,4475-4485]. tRNA1Lys is present in tRNA preparations extracted from RNase-treated mitochondria as well as from submitochondrial fractions, such as inner-membrane or mitosol preparations. It is absent in the mitochondrial outer-membrane preparation. These results show that the presence of tRNA1Lys in mitochondria is not a result of cytoplasmic contamination and suggest strongly that it is imported from the cytoplasm. This cytoplasmic tRNA seems not to be involved in the transfer of lysine into mtDNA-coded polypeptide chains since (1) it is not acylated by the mitochondrial aminoacyl-tRNA ligase preparation and (2) mtDNA-coded mitochondrial tRNA2Lys recognizes both lysine codons. It is postulated that the presence of tRNA1Lys in yeast mitochondria results from active transport involving a specific receptor (other than mitochondrial lysyl-tRNA ligase). This tRNA may have a regulatory role, and its function could give an important insight into the relationship between the mitochondrial and the nuclear-cytoplasmic systems.\n|Evidence ID||Analyze ID||Interactor||Interactor Systematic Name||Interactor||Interactor Systematic Name||Type||Assay||Annotation||Action||Modification||Phenotype||Source||Reference||Note|\n|Evidence ID||Analyze ID||Gene||Gene Systematic Name||Gene Ontology Term||Gene Ontology Term ID||Qualifier||Aspect||Method||Evidence||Source||Assigned On||Annotation Extension||Reference|\n|Evidence ID||Analyze ID||Gene||Gene Systematic Name||Phenotype||Experiment Type||Experiment Type Category||Mutant Information||Strain Background||Chemical||Details||Reference|\n|Evidence ID||Analyze ID||Regulator||Regulator Systematic Name||Target||Target Systematic Name||Experiment||Assay||Construct||Conditions||Strain Background||Reference|", "domain": "chemistry", "round": 3} +{"url": "https://studysaga.in/what-would-the-temperature-of-venus-be-if-its-atmosphere-was-the-same-or-similar-to-earths/", "date": "2023-11-28T13:54:31Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679099514.72/warc/CC-MAIN-20231128115347-20231128145347-00132.warc.gz", "language_score": 0.9584897756576538, "token_count": 279, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__152387002", "lang": "en", "text": "If Venus had an atmosphere similar to Earth’s, its surface temperature would be significantly cooler than it is with its current thick and dense atmosphere, which is mostly composed of carbon dioxide. The extremely hot surface temperatures on Venus, which can reach over 900 degrees Fahrenheit (475 degrees Celsius), are primarily due to the planet’s thick carbon dioxide-rich atmosphere, which creates a potent greenhouse effect.\nIn contrast, Earth’s atmosphere is composed mainly of nitrogen and oxygen, with a relatively low concentration of carbon dioxide. This composition allows Earth’s atmosphere to regulate temperature through the greenhouse effect, which involves trapping some of the sun’s energy, keeping the planet warm enough to support life but not excessively hot.\nIf Venus had an Earth-like atmosphere, it would have a milder greenhouse effect, which would result in more moderate surface temperatures. The exact temperature would depend on various factors, including the composition of the atmosphere and the planet’s distance from the sun.\nIn essence, if Venus had an atmosphere similar to Earth’s, its surface temperature would be considerably cooler and might even support conditions conducive to liquid water, a crucial element for the possibility of life as we know it. However, other factors, such as Venus’s proximity to the sun and its lack of a magnetic field, would still present challenges for habitability.", "domain": "chemistry", "round": 3} +{"url": "https://www.lckinhibitor.com/2020/08/27/15249/", "date": "2023-06-07T04:43:19Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-23/segments/1685224653608.76/warc/CC-MAIN-20230607042751-20230607072751-00179.warc.gz", "language_score": 0.9204210042953491, "token_count": 804, "dump": "CC-MAIN-2023-23", "global_id": "webtext-fineweb__CC-MAIN-2023-23__0__286677567", "lang": "en", "text": "Eted for the improvement of novel therapeutics aimed at treating pain, which includes cancer-induced discomfort. The Regulation of GA GA activity is regulated via many mechanisms. In vitro, the enzyme may be stimulated by adding inorganic phosphate, and it is consequently normally referred to as phosphateactivated (Fig. 1A). While exposure to low phosphate levels activates LGA, a response which is not inhibited by glutamate, KGA activity is dependent on high levels of phosphate and may be inhibited by glutamate . In specific, GAC transitions from a dimer to an active tetramer in vitro following the addition of 50 to one hundred mM of inorganic phosphate [36, 86]. The conditions above suggest that LGA and KGA are differentially regulated. A single activator of GLS2/LGA isadenosine diphosphate (ADP), which lowers the enzymatic Km, using the opposite effect occurring inside the presence of ATP, and both effects dependent on mitochondrial integrity . GLS2 is linked with elevated metabolism, decreased levels of intracellular reactive oxygen species (ROS), and decreased DNA oxidation in each typical and stressed cells. It has been suggested that the manage of ROS levels by GLS2 is mediated by p53 as a means of protecting cells from DNA harm, also supporting cell survival in response to genotoxic pressure . According to the cell sort, at the same time because the level and form of tension, the extent of GLS2 transcriptional up-regulation by p53 differs in standard and cancer cells . Good Regulators Relative to healthful tissue, the levels of GLS protein are elevated in breast tumours . In distinct, elevated GAC levels have already been connected using a larger grade of invasive ductal breast carcinoma . The oncogene c-Myc positively impacts glutamine metabolism, as its up-regulation is sufficient to drive mitochondrial glutaminolysis [88, 89]. In the two GLS isoforms, mitochondrial GAC is stimulated by c-Myc in transformed fibroblasts and breast cancer cells . c-Myc also indirectly influences GLS expression by means of its action on microRNA (miR) 23a and 23b . Beneath standard conditions, miR23a and b bind towards the 3′ untranslated region of GLS transcripts, thereby stopping translation. c-Myc transcriptionally suppresses miR-23a/b expression, de-repressing the block on GLS translation and thereby facilitating glutamine metabolism . Interestingly, acting by way of its p65 subunit, NF-B also positively regulates GLS expression by inhibiting miR-23a . NF-B would be the prevalent intermediary that modulates GA activation downstream of Rho GTPase signalling . Another protein regulating glutamine metabolism is signal transducer and activator of transcription (STAT) 1, the phosphorylated/ activated form of which binds within the GLS1 promoter area, with interferon alpha (IFN) -stimulated STAT1 activation up-regulating GLS1 expression . Mitogenactivated protein kinase (MAPK) signaling and adjustments in GA expression are also linked depending on a report demonstrating that KGA binds straight to MEK-ERK . Activation on the MEK-ERK pathway in response to epidermal growth aspect (EGF) therapy, or pathway inactivation by the selective MEK1/2 inhibitorU0126, activates or represses KGA activity, respectively, suggesting a phosphorylation-dependent mode of regulation . This latter point is in line with alkaline phosphatase exposure absolutely blocking basal GAC activity . Unfavorable Regulators There are many 497839-62-0 custom synthesis mechanisms by which GA is negatively regulated. Anaphase-.", "domain": "chemistry", "round": 3} +{"url": "https://www.kunststoffe.de/en/specialized-information/patents/artikel/anti-snaking-swellable-water-stops-1040820.html", "date": "2020-02-16T20:09:49Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-10/segments/1581875141396.22/warc/CC-MAIN-20200216182139-20200216212139-00030.warc.gz", "language_score": 0.8891637325286865, "token_count": 409, "dump": "CC-MAIN-2020-10", "global_id": "webtext-fineweb__CC-MAIN-2020-10__0__155522060", "lang": "en", "text": "Anti-Snaking Swellable Water-Stops\nThe invention provides an aqueously-swellable water stop having an elongate body formed by shaping or extruding a composition mixture comprising water swelling fillers and/or polymers (e.g. Bentonite, super absorbent polymers, hydrophilic polymers), at least one elastomer or polymer, and preferably at least one plasticizer, the composition mixture when formed into an elongate water stop body having a Shore A hardness (durometer) of less than 35 and more preferably in the range of 5-35 (measured at 21°C). The water stop body has at least one major face and a layer of pressure-sensitive adhesive attached to the face for bonding to a concrete substrate. The water stop of the invention does not require use of rigid metal and hard plastic inner cores as in prior water stop designs, and avoids curling and snaking that would allow concrete poured against the water stop to invade between the first substrate and the water stop body, and thereby providing full bonding between the water stop and thus protecting against leakage through concrete construction joints.\nClick here for the full patent text at DEPATISnet [PDF]\nPublished patent application\nDisclosure date: 10-24-2013\nPublication date: 04-29-2015\nApplicant: GRACE W R & CO, US\nInventor: DE RUIJTER MICHEL JAN, BE ; GEUDENS PASCAL AUGUST, BE ; KEMPENAERS PETER JOZEF, BE\n© European Patent Office. This information was obtained from the espacenet of the European Patent Office. There is no guarantee of its correctness or curency. For additional information, please use the research at espacenet. It is possible to determine the current legal and procedural status of patents and utility patents/models at http://worldwide.espacenet.com/ kfree of charge.", "domain": "chemistry", "round": 3} +{"url": "https://www.hindawi.com/journals/bmri/2007/018081/", "date": "2021-10-23T04:58:24Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-43/segments/1634323585561.4/warc/CC-MAIN-20211023033857-20211023063857-00340.warc.gz", "language_score": 0.7652409672737122, "token_count": 2263, "dump": "CC-MAIN-2021-43", "global_id": "webtext-fineweb__CC-MAIN-2021-43__0__246471947", "lang": "en", "text": "Biomedical Applications of Colloidal NanocrystalsView this Special Issue\nResearch Article | Open Access\nIbrahim Yildiz, Xinxin Gao, Thomas K. Harris, Françisco M. Raymo, \"Fluorescence Resonance Energy Transfer in Quantum Dot-Protein Kinase Assemblies\", BioMed Research International, vol. 2007, Article ID 018081, 5 pages, 2007. https://doi.org/10.1155/2007/18081\nFluorescence Resonance Energy Transfer in Quantum Dot-Protein Kinase Assemblies\nIn search of viable strategies to identify selective inhibitors of protein kinases, we have designed a binding assay to probe the interactions of human phosphoinositide-dependent protein kinase-1 (PDK1) with potential ligands. Our protocol is based on fluorescence resonance energy transfer (FRET) between semiconductor quantum dots (QDs) and organic dyes. Specifically, we have expressed and purified the catalytic kinase domain of PDK1 with an N-terminal histidine tag [-PDK1(PH)]. We have conjugated this construct to CdSe-ZnS core-shell QDs coated with dihydrolipoic acid (DHLA) and tested the response of the resulting assembly to a molecular dyad incorporating an ATP ligand and a BODIPY chromophore. The supramolecular association of the BODIPY-ATP dyad with the -PDK1(PH)-QD assembly encourages the transfer of energy from the QDs to the BODIPY dyes upon excitation. The addition of ATP results in the displacement of BODIPY-ATP from the binding domain of the -PDK1(PH) conjugated to the nanoparticles. The competitive binding, however, does not prevent the energy transfer process. A control experiment with QDs, lacking the -PDK1(PH), indicates that the BODIPY-ATP dyad adsorbs nonspecifically on the surface of the nanoparticles, promoting the transfer of energy from the CdSe core to the adsorbed BODIPY dyes. Thus, the implementation of FRET-based assays to probe the binding domain of PDK1 with luminescent QDs requires the identification of energy acceptors unable to interact nonspecifically with the surface of the nanoparticles.\n- K. E. Sapsford, L. Berti, and I. L. Medintz, “Materials for fluorescence resonance energy transfer analysis: beyond traditional donor-acceptor combinations,” Angewandte Chemie International Edition, vol. 45, no. 28, pp. 4562–4588, 2006.\n- A. R. Clapp, I. L. Medintz, and H. Mattoussi, “Förster resonance energy transfer investigations using quantum-dot fluorophores,” ChemPhysChem, vol. 7, no. 1, pp. 47–57, 2006.\n- A. C. S. Samia, S. Dayal, and C. Burda, “Quantum dot-based energy transfer: perspectives and potential for applications in photodynamic therapy,” Photochemistry and Photobiology, vol. 82, no. 3, pp. 617–625, 2006.\n- R. C. Somers, M. G. Bawendi, and D. G. Nocera, “CdSe nanocrystal based chem-/bio-sensors,” Chemical Society Reviews, vol. 36, no. 4, pp. 579–591, 2007.\n- F. M. Raymo and I. Yildiz, “Luminescent chemosensors based on semiconductor quantum dots,” Physical Chemistry Chemical Physics, vol. 9, no. 17, pp. 2036–2043, 2007.\n- I. L. Medintz, A. R. Clapp, H. Mattoussi, E. R. Goldman, B. Fisher, and J. M. Mauro, “Self-assembled nanoscale biosensors based on quantum dot FRET donors,” Nature Materials, vol. 2, no. 9, pp. 630–638, 2003.\n- E. R. Goldman, I. L. Medintz, J. L. Whitley et al., “A hybrid quantum dot-antibody fragment fluorescence resonance energy transfer-based TNT sensor,” Journal of the American Chemical Society, vol. 127, no. 18, pp. 6744–6751, 2005.\n- M. E. M. Noble, J. A. Endicott, and L. N. Johnson, “Protein kinase inhibitors: insights into drug design from structure,” Science, vol. 303, no. 5665, pp. 1800–1805, 2004.\n- S. P. Davies, H. Reddy, M. Caivano, and P. Cohen, “Specificity and mechanism of action of some commonly used protein kinase inhibitors,” Biochemical Journal, vol. 351, no. 1, pp. 95–105, 2000.\n- J. Bain, H. McLauchlan, M. Elliott, and P. Cohen, “The specificities of protein kinase inhibitors: an update,” Biochemical Journal, vol. 371, no. 1, pp. 199–204, 2003.\n- G. Manning, D. B. Whyte, R. Martinez, T. Hunter, and S. Sudarsanam, “The protein kinase complement of the human genome,” Science, vol. 298, no. 5600, pp. 1912–1934, 2002.\n- M. Huse and J. Kuriyan, “The conformational plasticity of protein kinases,” Cell, vol. 109, no. 3, pp. 275–282, 2002.\n- D. R. Alessi, M. Deak, A. Casamayor et al., “3-phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the drosophila DSTPK61 kinase,” Current Biology, vol. 7, no. 10, pp. 776–789, 1997.\n- R. M. Biondi, D. Komander, C. C. Thomas et al., “High resolution crystal structure of the human PDK1 catalytic domain defines the regulatory phosphopeptide docking site,” The EMBO Journal, vol. 21, no. 16, pp. 4219–4228, 2002.\n- X. Gao and T. K. Harris, “Steady-state kinetic mechanism of PDK1,” Journal of Biological Chemistry, vol. 281, no. 31, pp. 21670–21681, 2006.\n- X. Gao and T. K. Harris, “Role of the PH domain in regulating in vitro autophosphorylation events required for reconstitution of PDK1 catalytic activity,” Bioorganic Chemistry, vol. 34, no. 4, pp. 200–223, 2006.\n- R. M. Biondi, P. C. F. Cheung, A. Casamayor, M. Deak, R. A. Currie, and D. R. Alessi, “Identification of a pocket in the PDK1 kinase domain that interacts with PIF and the C-terminal residues of PKA,” The EMBO Journal, vol. 19, no. 5, pp. 979–988, 2000.\n- R. M. Biondi, A. Kieloch, R. A. Currie, M. Deak, and D. R. Alessi, “The PIF-binding pocket in PDK1 is essential for activation of S6K and SGK, but not PKB,” The EMBO Journal, vol. 20, no. 16, pp. 4380–4390, 2001.\n- M. Frödin, T. L. Antal, B. A. Dümmler et al., “A phosphoserine/threonine-binding pocket in AGC kinases and PDK1 mediates activation by hydrophobic motif phosphorylation,” The EMBO Journal, vol. 21, no. 20, pp. 5396–5407, 2002.\n- M. Engel, V. Hindie, L. A. Lopez-Garcia et al., “Allosteric activation of the protein kinase PDK1 with low molecular weight compounds,” The EMBO Journal, vol. 25, no. 23, pp. 5469–5480, 2006.\n- B. O. Dabbousi, J. Rodriguez-Viejo, F. V. Mikulec et al., “(CdSe)ZnS core-shell quantum dots: synthesis and characterization of a size series of highly luminescent nanocrystallites,” Journal of Physical Chemistry B, vol. 101, no. 46, pp. 9463–9475, 1997.\n- Z. A. Peng and X. Peng, “Formation of high-quality CdTe, CdSe, and CdS nanocrystals using CdO as precursor,” Journal of the American Chemical Society, vol. 123, no. 1, pp. 183–184, 2001.\n- H. Mattoussi, J. M. Mauro, E. R. Goldman et al., “Self-assembly of CdSe-ZnS quantum dot bioconjugates using an engineered recombinant protein,” Journal of the American Chemical Society, vol. 122, no. 49, pp. 12142–12150, 2000.\n- X. Gao, P. Yo, and T. K. Harris, “Improved yields for baculovirus-mediated expression of human -PDK1 and -PKB/Akt2 and characterization of phospho-specific isoforms for design of inhibitors that stabilize inactive conformations,” Protein Expression and Purification, vol. 43, no. 1, pp. 44–56, 2005.\nCopyright © 2007 Ibrahim Yildiz et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.", "domain": "chemistry", "round": 3} +{"url": "https://www.nist.gov/publications/effects-processing-microstructure-and-mechanical-properties-ti-6al-4v-fabricated-0?pub_id=912253", "date": "2017-06-23T05:35:33Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-26/segments/1498128320003.94/warc/CC-MAIN-20170623045423-20170623065423-00485.warc.gz", "language_score": 0.9235435724258423, "token_count": 291, "dump": "CC-MAIN-2017-26", "global_id": "webtext-fineweb__CC-MAIN-2017-26__0__46246932", "lang": "en", "text": "Selective electron beam melting (EBM) is a layer-by-layer additive manufacturing technique that shows great promise for fabrication of medical devices and aerospace components. Before its potential can be fully realized, however, a deeper understanding of processing-microstructure-properties relationships is necessary. Titanium alloy (Ti-6Al-4V) samples were built in a newly developed, unique geometry to allow accurate investigation of the following intra-build processing parameters: energy input, orientation, and location. Microstructure evaluation (qualitative prior-β grain size, quantitative α lath thickness), tensile testing, and Vickers microhardness was performed for each sample. For a wide range of energy input (speed factor 30-40), small differences in mechanical properties (2 % change ultimate tensile strength (UTS), 3 % change yield strength (YS)) were measured. Vertically built samples were found to have no difference in UTS or YS compared to horizontally built samples, but the % EL was 30 % lower. Orientation within the x-y plane as well as location were found to have less than 3% effect on mechanical properties, and it is possible a second order effect of thermal mass contributed to these results.\nCitation: Materials Science and Engineering A-Structural Materials Properties Microstructure and Processing\nPub Type: Journals\nElectron beam melting, titanium alloy, tensile, microhardness, microstructure", "domain": "chemistry", "round": 3} +{"url": "http://abstracts.ects-ibms2015.org/ectsibms/0001/ectsibms0001p210.htm", "date": "2018-11-13T04:28:28Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-47/segments/1542039741219.9/warc/CC-MAIN-20181113041552-20181113063552-00370.warc.gz", "language_score": 0.9137399792671204, "token_count": 480, "dump": "CC-MAIN-2018-47", "global_id": "webtext-fineweb__CC-MAIN-2018-47__0__169155095", "lang": "en", "text": "Receptor activator of nuclear factor-κB ligand (RANKL), a trimeric tumour necrosis factor (TNF) superfamily member, is the central mediator of osteoclast formation and bone resorption. Functional mutations in RANKL lead to human autosomal recessive osteopetrosis, whereas RANKL overexpression has been implicated in the pathogenesis of bone degenerative diseases such as osteoporosis. Following a forward genetics approach, we have recently shown that a novel loss-of-function allele of Rankl with a glycine-to-arginine susbstitution at codon 278, causes severe recessive osteopetrosis in mice due to inhibition of RANKL trimerisation. Notably, SPD304, a small molecule inhibitor of TNF trimerisation, also binds and inhibits RANKL, suggesting similar inhibitory mechanisms. However, SPD304 displays high cell toxicity. Based on the trimeric structure of RANKL and its interaction with SPD304, novel small molecules were designed to abrogate RANKL trimer formation and biological function while also displaying lower toxicity. Of the 72 SPD304-like derivatives synthesised and tested, 8 displayed complete inhibition of human RANKL-induced osteoclastogenesis at 5 μM without affecting the differentiation of the preosteoblastic MC3T3-E1 cells. Notably, these compounds were significantly less cytotoxic compared with SPD304 as shown by MTT. Moreover, the most effective small molecule inhibitors dissociated human RANKL trimers as shown by cross linking and western blot and suppressed the activation of NFATc1, the master regulator of osteoclast formation. Our research identified potent small molecule inhibitors of human RANKL designed to target and block its trimerisation. The more effective inhibitors will be further evaluated in vivo using our unique human RANKL-expressing transgenic mouse models of osteoporosis.\nDisclosure: The authors declared no competing interests. This work was funded by project TheRAlead (09ΣϒN-21-784) which is Co-financed by the European Union (European Regional Development Fund) and Greece, Operational Program Competitiveness & Entrepreneurship, NSRF 2007-2013 in the context of GSRT-National action Cooperation.", "domain": "chemistry", "round": 3} +{"url": "https://www.outsourcing-pharma.com/Article/2013/08/28/US-FDA-Clarifies-Guidance-on-Intermediate-Stability-Data-Generics", "date": "2023-06-06T09:09:44Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-23/segments/1685224652494.25/warc/CC-MAIN-20230606082037-20230606112037-00575.warc.gz", "language_score": 0.9353466629981995, "token_count": 710, "dump": "CC-MAIN-2023-23", "global_id": "webtext-fineweb__CC-MAIN-2023-23__0__299464398", "lang": "en", "text": "US FDA Clarifies Guidance on Intermediate Stability Data for Generic Manufacturers\nThe recently released Q&A notes that at the time of an ANDA (abbreviated new drug application) submission, the stability data expectation is six months of accelerated and six months of long-term data. However, the FDA says that “if 6 months accelerated data show significant change or failure of any attribute, 6 months of intermediate data are also recommended at the time of submission.”\nThe agency also breaks down a number of more specific questions on whether two lots of finished product at pilot scale batch size can ever be sufficient to support the stability of an ANDA for simple dosage forms (it can’t, says the FDA); and whether a company can file with 3 months stability data with a commitment to supply 6 months data when available if a patent is due to shortly expire and there are no approved ANDAs (also a negative, according to the agency.)\nThe FDA also extended the implementation date of the guidance from Jan. 1, 2014 to June 20, 2014.\nMichael D. Barron, MBA, director of business development at Quality Chemical Laboratories, told In-Pharmatechnologist.com, \"The intermediate stability storage condition Q&A is pretty clear...The meaning is to follow the ICH Q1A (R2). For companies which have been doing that it is clear the best strategy is to 'set' the stability studies into all storage conditions at the same time and only test the intermediate if or when significant change occurs at accelerated.\n\"The meaning of providing 6 months data on intermediate at the time of submission (in that case) would mean the only data point on the 30/65 sample would be the 6 month timepoint (besides the initial timepoint which applies to all conditions). Following ICH Q1A (R2), you then have to commit to two more stability timepoints at 30/65, i.e. the 9 and 12 month timepoints. Perhaps that is the piece that generic companies not familiar with ICH need to understand,\" he said.\nThe FDA also reminds companies that a “minimum of two lots of the drug substance [or API] should be used to prepare the three primary batches of drug product.”\nAs far as API sourcing, the agency recommends that if a company proposes to add a second or more than two sources of API for the same drug substance, CMC information should include:\n- Comparison and justification of comparability (by the firm) of the physico-chemical properties and impurities of the drug substance from each source;\n- Appropriate stability data on three batches of drug product qualifying the first API source used in the bioequivalence (BE) studies as recommended by the stability guidance;\n- A single pilot scale batch of the drug product bio-strength(s) manufactured using the second or each of the other proposed API source(s) used to support the ANDA application, along with comparative dissolution data; and\n- Appropriate stability data (accelerated and long-term for 6 months at the time of filing) on the strength(s) manufactured for each API source, which may in some cases include intermediate condition stability data.\nAll manufacturers also should follow the International Conference on Harmonisation (ICH) guidance for industry on Q1D Bracketing and Matrixing Designs for Stability Testing of New Drug Substances and Products and its example tables.", "domain": "chemistry", "round": 3} +{"url": "https://www.ars.usda.gov/research/publications/publication/?seqNo115=290904", "date": "2023-09-29T10:20:23Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233510501.83/warc/CC-MAIN-20230929090526-20230929120526-00245.warc.gz", "language_score": 0.9447782635688782, "token_count": 758, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__121797465", "lang": "en", "text": "|SERPE, MARCELO - Boise State University|\n|JIA, YING - Texas A&M University|\nSubmitted to: Planta\nPublication Type: Peer Reviewed Journal\nPublication Acceptance Date: 4/16/2013\nPublication Date: 7/1/2013\nCitation: Chao, W.S., Serpe, M., Suttle, J.C., Jia, Y. 2013. Increase in ACC oxidase levels and activities during paradormancy release of leafy spurge (Euphorbia esula) buds. Planta. 238:205-215.\nInterpretive Summary: Ethylene participates in the regulation of multiple physiological and developmental processes. Given that ethylene can promote growth at various stages of development and under different environmental conditions, we hypothesized that this hormone may also be involved in growth of leafy spurge buds, particularly after paradormancy release (growth induction) following removal of the aerial portion of the plant. To explore this notion, we examined ethylene production and the expression and activity of the ethylene biosynthetic enzyme ACC oxidase. A gene encoding a Euphorbia esula ACC oxidase (Ee-ACO) was cloned and the protein expressed from this clone was used to generate an antibody against this enzyme. This study reports the expression, activity, and localization of the Ee-ACO enzyme during bud growth induction. Our results revealed that the release from paradormancy in leafy spurge leads to an increase in ACO expression and a rise in ACO activity in bud protein extracts.\nTechnical Abstract: The plant hormone ethylene is known to affect various developmental processes including dormancy and growth. Yet, little information is available about ethylene’s role during paradormancy break in adventitious buds of leafy spurge. In this study, we examined changes in ethylene evolution and the ethylene biosynthetic enzyme ACC oxidase following paradormancy release (growth induction). Our results did not show an obvious increase in ethylene during bud growth. However, when buds were incubated with 1 mM ACC, ethylene levels were higher in growing than non-growing buds, suggesting that the levels of ACC oxidase increased in growing buds. Real-time qPCR indicated that the transcript of a Euphorbia esula ACC oxidase (Ee-ACO) increased up to 3-fold following growth induction. In addition, a 2.5- to 4-fold increase in ACO activity was observed 4 days after decapitation, and the Ee-ACO accounted for as much as 40% of the total ACO activity. Furthermore, immunoblot analyses identified a 36-kD Ee-ACO protein that increased in expression during bud growth. This protein was highly expressed in leaves, moderately expressed in crown buds, stems and meristems, and weakly expressed in roots and flowers. Immunolocalization of Ee-ACO on growing bud sections revealed strong labeling of the nucleus and cytoplasm in cells at the shoot apical meristem and leaf primordia. An exception to this pattern occurred in cells undergoing mitosis, where labeling of Ee-ACO was negligible. Taken together, our results indicate a complex regulation of ACO activity during pardormancy release of leafy spurge buds. In these buds, ACO activity is not only correlated to the expression of the gene encoding this enzyme, but also appears to be affected by the levels of cofactors and substrates that are required for ACO activity.", "domain": "chemistry", "round": 3} +{"url": "https://www.trp.org.in/issues/an-experimental-study-on-self-healing-concrete-using-bacteria", "date": "2021-04-23T17:12:11Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-17/segments/1618039596883.98/warc/CC-MAIN-20210423161713-20210423191713-00351.warc.gz", "language_score": 0.8362718820571899, "token_count": 1152, "dump": "CC-MAIN-2021-17", "global_id": "webtext-fineweb__CC-MAIN-2021-17__0__114025428", "lang": "en", "text": "The Asian Review of Civil Engineering (TARCE)\nAn Experimental Study on Self Healing Concrete Using BacteriaAuthor : N. Srimathi, K. Anu Indravathi , M. Hajira Amreen and S. Indhuurekha\nVolume 7 No.2 July-December 2018 pp 16-19\nConcrete will prolong to be the important material for building construction, but this concrete structure are subjected to cracking .These cracks on the surface of the concrete make whole structure obnoxious because of the water that ooze into the concrete. These cracks can be rehabilitated by self-healing concrete which will biologically produce limestone. There are two self-healing agent parts they are the bacterial spores and the calcium lactate. These agents are introduced to the concrete during the cement-mixing process. Therefore the bacteria that satisfy the above norms are Bacillus pasteurii and its optimum temperature is 35º- 45º. It is an environmentally, friendly, biotic process and it is also a self-remediating process. These self-healing concrete is potential of lengthening in service life of public buildings. The aim of our project is to develop a new type of concrete in which bacteria promote self-healing of cracks. Various tests such as compressive strength test, split tensile strength test and flexural strength test will be carried out. The grade of concrete used in our project is M20.\nBacillus Megaterium, Steam Curing, Bacterial Preparation\n Rajesh Talluri, Prathap Mathangi and Venkateshwarlu Musini, “A Critical Review on Bacterial Concrete”.\n Henk M. Jonkersa, Arjan Thijssena, Gerard Muyzerb, Oguzhan Copuroglua and Erik Schlangena, “Application of Bacteria as Self-Healing Agent for the Development of Sustainable Concrete”.\n H. M. Jonkers, “Self-healing concrete: a biological approach, in S. van der Zwaag (ed) Self-healing materials”, An Alternative Approach to 20 Centuries of Materials Science, 2007.\n A. Rahman, M. Sam, N. F. Ariffin, M. Warid, H. S. Lee, M. A. Ismail and M. Samadi, “Performance of epoxy resin as self-healing agent”, JurnalTeknologi, Vol. 16, pp. 9–13, 2015.\n A. Talaiekhozan, A. Keyvanfar, A. Shafaghat, R. Andalib, M. Z. A. Majid and M. A. Fulazzaky, “Review Of Self-Healing Concrete Research Development”, J. Environ. Treat. Tech., Vol. 2, No. 1, pp. 1–11, 2014.\n A. Vahabi, A.A. Ramezanianpour, H. Sharafi, H.S. Zahiri, H. Vali and K.A. Noghabi, “Calcium carbonate precipitation by strain Bacillus licheniformis AK01, newly isolated from loamy soil: a promising alternative for sealing cement-based materials”, J. Basic Microbiol.,2013.\n C. X. Qian, M. Luo, L. F. Ren, R. X. Wang, R.Y. Li, Q. F. Pan and H. C. Chen, “Self-healingand repairing concrete cracks based on bio-mineralization”, Key Eng. Mater., pp. 494–503, October 2014.\n C. M. Dry, “Three designs for the internal release of sealants, adhesives, and waterproofing chemicals into concrete to reduce permeability”, Cement and Concrete Research, Vol. 30, No. 12, pp. 1969-1977, 2000.\n E. Schlangen and S. Sangadji, “Addressing infrastructure durability and sustainability by self-healing mechanisms – recent advances in self-healing concrete and asphalt”, Procedia Eng., Vol. 54, pp. 39–57, 2013.\n H. Afifudin, M. S. Hamidah, H. Noor Hana and K. Kartini, “Microorganism precipitation in enhancing concrete properties”, Appl. Mech. Mater., pp. 1157–1165, 2011.\n H. M. Jonkers, A. Thijssen, G. Muyzer, O. Copuroglu and E. Schlangen, “Application Of bacteria as self-healing agent for the development of sustainable concrete”, Ecol. Eng. , Vol. 36 , No. 2, pp. 230–235, 2010.\n H. M. Jonkers and E. Schlangen, “A two component bacteria-based self-healing concrete, in: Concrete Repair”, Rehabilitation & Retrofitting II, Taylor &Francis Group, pp. 215–220, 2009. ISBN 978-0-415-46869-3.\n H. M. Jonker and E. Schlangen, “Development of a bacteria-based self-healing concrete, in: Taylor Made Concrete Structures”, Taylor & Francis group, London, pp. 425–430, 2008.", "domain": "chemistry", "round": 3} +{"url": "http://bjas.bu.edu.eg/result_issue.php?vid=1", "date": "2020-01-19T23:46:16Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-05/segments/1579250595787.7/warc/CC-MAIN-20200119234426-20200120022426-00244.warc.gz", "language_score": 0.7119176983833313, "token_count": 1627, "dump": "CC-MAIN-2020-05", "global_id": "webtext-fineweb__CC-MAIN-2020-05__0__100511576", "lang": "en", "text": "1- Comparative Studies on The Extraction of Cobalt from Chloride Medium using Different ExtractantsS. A. El-reefya, A. S. Shalabib, N. H. M. Kamelc, Ahmed T. El-senbawyc* a Analytical Chemistry Dep., Hot Laboratories Center, AEA, Egypt b Chemistry Dep., Faculty of Science, Benha Univ. c Radiation Protection Department, Nuclear Research Center, AE\n2- An Optimization Study for Flotation of Egyptian PhosphateoreNagui A. Abdel-Khalek , Khaled A. Selim , A. A. El-Bellihi , W. A. Bayoumy, Mahmoud M. Abdallah Central Metallurgical Research and Development Institute (CMRDI), Helwan, Egypt. Faculty of Science, Chemistry Department, Benha University, Benha, Egyp\n3- Physico-Chemical and Mechanical Characteristics of Superplasticizedcomposite Cements Containing High Replacement Siliceous Fly AshMohamed Heikal1, 2, A.I. Ali1, M.N. Ismail 3, B.S. Ibrahim1 1Chemistry Department, Faculty of Science, Benha University, Benha, Egypt 2 Department, College of Science, Al Imam Mohammad Ibn Saud, Islamic University (IMSIU), P.O Box 90950, Riyadh 116\n4- `Removal of Some Heavy Metals from Electrical Power Plant Effluents Discharged into Aquatic Ecosystem Using Low Cost AdsorbentsM.I.Alya*, H. M. H. Gada, M.H. Abdob, M.H.M. Radwanc&M. Mahmoudc aHot Laboratories and Waste Management Center, Egyptian Atomic Energy Authority, P. O. Box 13759, Inshas, Cairo, Egypt. bNational Institute of Oceanography and Fisheries cChemistry D\n5- Electron Donor-Acceptor Interaction Parameters of Calcon Carboxylic Acid with Nano Cobalt Sulphate in Methanol (Meoh) - Water at Different Temperatures by Applying Conductance Studies.Esam A Gomaa1*, M. A. Mousa 2*, Mohamed Khairy2*And Abdo Shokr2* 1*Chemistry Department, Faculty of Science, Mansoura University, 35516-Mansoura, Egypt. 2*Chemistry Department, Faculty of Science, Benha University, Benha, Egypt.\n6- Adsorption of Cu2+ Ion from Aqueous Solution by Clam Shell PowderHisham. M.Aly1, Sayed A. Shama1, Abdel Azem M. Elsharkawy1, Abdel Fatah I. Helal2and Amal1 M. Khodir Chemistry Department, Faculity of Science, Benha University, Benha, Egypt, Nuclear Research Center, Nuclear Physics Department, Atomic Authority, Ca\n7- Synthesis, Characterization and Application of Poly (Acrylamide-Maleic Acid-Acrylonitrile) by Gamma Irradiation Induced Grafting PolymerizationE.H.Boraia, M.G.Hameda, A.M.El-Kamasha, T.Siyama And G.O.El-Sayed B AHot Laboratories Center, Atomic Energy Authority, 13759, Egypt B Chemistry Department, Benha University, Egypt\n8- Studies on the Adsorption Behavior of La3+, Ce3+, Nd3+ and Sm3+ on Synthesized Poly-o-Toluidine Zr(IV) Tungstophosphate CompositeE. S. Zakariaa, I. M. Alia, M. Khalil a, T.Y. Mohamedb and A. El-tantawya aAtomic Energy Authority, Hot Labs. Center, P. No. 13759, Egypt. bFaculty of Science, Chemistry Dep., BenhaUniversity.\n9- Fine Structure Calculations of the Energy Levels, Oscillator Strength and Transition Probabilities for as Like GalliumA. I. Refaie1, M. S. M. Nour El-Din2, L. M. Ahamed2 And S. H. Allam1 1-Physics Department, Faculty of Science, Benha University, Benha, Egypt 2-Physics Department, Faculty of Science, Cairo University, Cairo, Egypt\n10- Periodic Solutions of Modified Duffing Equation Subjected to Abi-Harmonic Parametric and External ExcitationsA. M. Elnaggar, A. F. El-Bassiouny, K. M. Khalil and A. M. Omran Department of Mathematics, Faculty of Science, Benha University, Egypt, B. O. 13518\n11- Net Charge Fluctuations and Chemical Freez-out ConditionsA.Tawfik 1, 2, L.I.Abou-Salem 2, Asmaa Shalaby 2, 3, M.Hanafy 2 1 Egyptian Center for Theoretical Physics (ECTP), Modern University for Technology and Information (MTI), 11571 Cairo, Egypt 2World Laboratory for Cosmology and Particle Physics (WLCA\n12- Evaluation of an Expired Non-Toxic Amlodipine Besylatedrug as Corrosion Inhibitor For Low Carbon Steel in Hydrochloric Acid SolutionsA.S. Fouda1, M. S. Motawee2, H. E. Megahid3, H. A. Abdul Mageed Chemistry Department, Faculty of Science, Benha University, Benha-35516, Egypt,\n13- On Stability of Nonlinear Differential System Via Cone-Perturbing Laipunov Function MethodDepartment of Mathematics, Faculty of Science, P. O. Box 13518, Benha University, Egypt\n14- Synthesis, Characterization and Copolymerizations of N-Methacryloxyphthalimide with Styrene for Removal of Cu(II) Ions from Aqueous SolutionsA. A. Khalil1, M. N. Ismail2 And B .S. Elewa3 1 Chemistry Department, Faculty of Science, Benha University, Benha, Egypt. 2 Polymer & Pigments Department, National Research Centre , Dokki, Giza, Egypt. P. O. Box 12622. 3 Basic Science Department,\n15- Effect of Newly Prepared Admixture on The Rheology and Early Hydration Characteristics of The Oil Well Cement Pastes.S. A. Abo-El-Enein, S. M. A. El-Gamal, I. A. Aiad*, M. M. Azab **, O. A. Mohamed **. Faculty of Science, Chemistry Department, Ain Shams University, Egypt. * Egyptian Petroleum Research Institute, EPRI, Cairo, Egypt. ** Faculty of Science, Chemist\n16- Optimizing the Biofuel Production by Hydrotreating Jojoba OilS.A El khatib1, S.A. hanafi 1, M.M.H. Arief 2 and E.F.Al-Amrousi 1 1Egyptian Petroleum Research Institute, Nasr City Cairo Egypt 2Faculty of Science, Benha University Egypt\n17- Inhibitive Action of Polymeric Surfactants on the Corrosion of C- steel in 0.5M HCl.A. A. Abdel-Fattah, H. E. Megahed, A. A. Ali and S. M. Syam. Chemistry Department, Faculty of Science, Benha University.", "domain": "chemistry", "round": 3} +{"url": "http://www.infiniteunknown.net/tag/tsuruga/", "date": "2017-03-27T14:38:26Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-13/segments/1490218189474.87/warc/CC-MAIN-20170322212949-00021-ip-10-233-31-227.ec2.internal.warc.gz", "language_score": 0.9410188794136047, "token_count": 411, "dump": "CC-MAIN-2017-13", "global_id": "webtext-fineweb__CC-MAIN-2017-13__0__123343689", "lang": "en", "text": "May 9 (Reuters) – Electricity wholesaler Japan Atomic Power said on Monday that gas containing a minute amount of radiation had leaked from its Tsuruga nuclear plant in western Japan the previous day, but that the amount was well below the legal limit and there was no impact on the environment.\nThe amount of radiation was estimated at about one-four hundred thousandth of the annual legal limit, and there were no changes in readings from radiation monitoring devices set up around the plant, the company said.\n“The amount that came out was such an extremely small amount, so this is not a problem and it will not have an impact on the environment,” said Shinichi Morooka, professor of nuclear energy at Waseda University.\nContinue reading »\nTags: Environment, Global News, Japan, Nuclear, Nuclear reactors, Radiation, Tsuruga\n– URGENT: Radiation leaks from fuel rods suspected at Tsuruga plant: local gov’t (Kyodo News)\n– Radiation leaks from fuel rods suspected at Tsuruga plant (Kyodo News):\nFUKUI, Japan, May 2, Kyodo\nLeaks of radioactive substances from fuel rods are suspected to have occurred at a nuclear power plant in Tsuruga, the Fukui prefectural government said Monday, citing a rise in the level of radioactive substances in coolant water.\nThe operator, Japan Atomic Power Co., will manually shut down the No. 2 reactor of the plant on the Sea of Japan coast and examine the primary cooling system for it. The local government denied that the levels of radioactive substances could threaten the nearby environment.\nAccording to Japan Atomic, 4.2 becquerels of iodine-133 and 3,900 becquerels of xenon gas were detected per cubic centimeter Monday, up from 2.1 and 5.2 becquerels, respectively, during previous measurements conducted last Tuesday.\nTags: Global News, Japan, Nuclear, Nuclear reactors, Radiation, Tsuruga", "domain": "chemistry", "round": 3} +{"url": "https://m.scirp.org/papers/50237", "date": "2022-10-02T01:13:55Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-40/segments/1664030336978.73/warc/CC-MAIN-20221001230322-20221002020322-00358.warc.gz", "language_score": 0.6644203066825867, "token_count": 302, "dump": "CC-MAIN-2022-40", "global_id": "webtext-fineweb__CC-MAIN-2022-40__0__244536419", "lang": "en", "text": "Onzawa, T., Suzumura, A. and Ko, M. (2011) Structure and Mechanical Properties of CP Ti and Ti-6Al-4V Alloy Joints Brazed with Ti-Based Amorphous Filler Metals. Journal of the Japan Welding Society, 5, 205-211.\n Huang, Y.J., et al. (2008) Formation, Thermal Stability and Mechanical Properties of Ti42.5Zr7.5Cu40Ni5Sn5 Bulk Metallic Glass. Science in China Series G: Physics, Mechanics and Astronomy, 51, 372-378.\n Takemoto, T. (1988) Intermetallic Compounds Formed during Brazing of Titanium with Aluminum Filler Metals. Journal of Material Science, 6, 1301-1308.\n Elrefaey, A. and Tillmann, W. (2007) Interface Characteristics and Mechanical Properties of the Vacuum-Brazed Joint of Titanium-Steel Having a Silver-Based Brazing Alloy. Metallurgical and Materials Transactions, 38, 2956-2961.", "domain": "chemistry", "round": 3} +{"url": "https://agenparl.eu/folic-acid-functionalized-magnetic-nanoprobes-via-pamam-dendrimers-sa-biotin-mediated-cascade-amplifying-system-for-efficient-enrichment-of-circulating-tumor-cells/", "date": "2020-10-19T22:23:46Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-45/segments/1603107866404.1/warc/CC-MAIN-20201019203523-20201019233523-00605.warc.gz", "language_score": 0.9268770813941956, "token_count": 405, "dump": "CC-MAIN-2020-45", "global_id": "webtext-fineweb__CC-MAIN-2020-45__0__203991061", "lang": "en", "text": "(AGENPARL) – LONDON (UNITED KINGDOM), ven 18 settembre 2020\nCirculating tumor cells (CTCs), as a liquid biopsy, have great significance for early diagnosis, timely treatment, and practical evaluation of metastasis or recurrence of cancer. However, the enrichment of rare CTCs in complex blood samples is still a significant challenge. Here, a unique highly-sensitive folic acid (FA)-functionalized cascade amplification system-modified magnetic nanoparticles (MNPs) is constructed for effectively capturing CTCs in whole blood. In this system, numerous FA, as a targeted molecule, were conjugated on the surface of PAMAM dendrimers (PAMAM-FA) (first amplification) through a polyethylene glycol (PEG) linker, which could promote the more comfortable binding of folate receptors (FR) on the surface of ovarian cancer cells (SKOV3 cells). Then, the PAMAM-FA was further modified with biotin to fabricate biotin-PAMAM-FA (BPF), which could combine with streptavidin (SA)-modified MNPs (SMs) via the SA-biotin system for efficiently targeting and separating CTCs. The capture efficiency of the constructed MNPs-SA~biotin-PAMAM-FA (SM@BPF) nanoprobes was 90.3% with high cell viability (~ 93.2%) and minimal non-specific adsorption (~ 25%). Moreover, fewer nanoprobes were absorbed on the surface of SM@BPF-captured SKOV3 cells (one-step method) compared with SM/BPF-captured SKOV3 cells (two-step method), which was beneficial for further biological analysis. We expect such a recognition molecule-based cascade amplification system will provide an innovative CTCs enrichment platform for early-stage diagnosis of ovarian cancer.\nYou have access to this article", "domain": "chemistry", "round": 3} +{"url": "https://www.greengredients.it/homepage/formulations/makeup/long-lasting-mascara/", "date": "2024-03-05T07:26:50Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707948223038.94/warc/CC-MAIN-20240305060427-20240305090427-00449.warc.gz", "language_score": 0.7743744850158691, "token_count": 564, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__169343210", "lang": "en", "text": "Presenting our Long Lasting Mascara, a standout product in our makeup line that embodies the fusion of advanced technology with the latest in cosmetic trends.\nDesigned for today’s fast-paced lifestyle, this mascara meets the increasing demand for all-day wear makeup. Its smudge-proof, water-resistant formula ensures exceptional durability, perfect for long hours and varying conditions. In response to the trend for Intense and bold eye makeup, our mascara provides deep pigmentation and dramatic volume, enhancing the eyes with a striking effect.\nThis product exemplifies our commitment to creating makeup that combines lasting wearability with impactful aesthetic results, catering to the modern consumer’s desire for both resilience and style in their makeup choices.\nThe Long Lasting Mascara features key ingredients from our production:\nSILGREEN® C: A plant-derived alternative to volatile silicone, providing a dry silicone-like texture that enhances the spreadability of white cosmetics. Acts effectively as a dispersant for coloring pigments in cosmetics and filters in sun care products.\nSESAMULS® OW: A COSMOS and NATRUE approved Oil in Water emulsifier, free of PEG, designed for liquid crystal emulsions. Capable of incorporating up to 70% of high or medium polarity natural lipids, providing stability and replacing traditional combinations of emulsifiers and dimethicone.\nSTABILGREEN® K: A 100% natural hydrophilic lipid, stabilizes even the most complex emulsions, imparting a fresh and light feel with a pleasant velvety effect. Acts as an effective co-emulsifying system, enhancing the stability of Oil in Water emulsions and reducing the amount of primary emulsifier. Also serves as a valuable troubleshooter, aiding in the correction of unstable emulsions during cold processing.\nThis formulation, featuring ingredients selected for their specific functions, delivers a long-lasting mascara with stability and a pleasing sensory experience.\n|C13/15 Alkane, Polyglyceryl-6 Oleate\n|C12-15 Alkyl Benzoate\n|Copernicia Prunifera (Carnauba) Wax\n|Polyglyceryl-3 Cetyl Ether, Sesamum Indicum (Sesame) Seed Oil, Malic Acid\n|Polyglyceryl-4 Oleyl Ether, Oleyl Phosphate\n|Black Iron Oxide CI 77499\n|DISPERSED CARBON BLACK\n|Olive Glycerides CI 77266\n|Tetrasodium Glutamate Diacetate\nContact us for more informations about this formulations and to receive the complete version with % dosage.", "domain": "chemistry", "round": 3} +{"url": "http://parakkattumaklubes.com/faq", "date": "2022-01-21T02:50:38Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-05/segments/1642320302715.38/warc/CC-MAIN-20220121010736-20220121040736-00687.warc.gz", "language_score": 0.9197863936424255, "token_count": 1738, "dump": "CC-MAIN-2022-05", "global_id": "webtext-fineweb__CC-MAIN-2022-05__0__246562853", "lang": "en", "text": "Engine oils of the same performance level/specifications are compatible and hence can be mixed / used for top ups.\nColour does not affect the performance of the grease. Different components in the grease can make the colour of the grease different.\nNo, blue smoke is due to oil getting mixed up with fuel in the engine.\nNo. The type of oil is specified based on the design of the vehicle and it is normally recommended by OEMs (full form)\nOil has to be bought only from reliable sources else one will end up using inferior quality products resulting in damage of engine\nNo. Change depends on Kms the vehicle has run, OE recommendations and operating condition.\nNot necessarily, because oil can turn black due to improper draining of oil while changing, poor maintenance, or quality of previously used oil and fuel, excessive carbon deposits on engine parts etc.. In fact oil will tend to blacken as it cleans the engine & various parts and accumulates dirt particles in itself\nColour does not affect the performance of the oil. Different colour dyes are added to differentiate brands. Red colour masks oil colour which otherwise looks dark and blackish due to impurities.\nThe oil quality gets reduced while in service due to oxidation of the oil and/or contamination of the oil and / or depletion of the additives as it gets used up during its service. Oxidation of the Oil in presence of air & high temperature produces acidic and gummy substances. If it is allowed to increase beyond certain limits then it will start corroding the equipment or leave unwanted deposits on the moving parts. Similarly contamination of the oil with water, dust, dirt and soot from combustion products leads to corrosion and abrassive wear. The TBN, Antiwear and performance enhancing additive gets used up in service and below certain levels will not be in a position to protect the equipment. Because of these primary reasons that we need to change the oil once it looses its useful life to protect our costly equipment.\nFaqs What is Low smoke oil for Two Stroke Engines? Why I need to use special 4T oil for my 4 Stroke Motor Cycle Engines? How to select the right viscosity of oil for my equipment? What is Multi-grade Oil & the Benefits of using Multi-grade Oil? Why there are many types of Engine Oils in the market for Petrol & Diesel Engines? What is the purpose of used oil analysis? Why we need to change the oil? When do we change the Oil? Can I use the after market additives in the oil to enhance the performance of the oil? How do I dispose of the Used Oil? Are Biodegradable oils marketed by BPCL? What is Group II base oil? What are the advantages of using Lubricants manufactured with Group II base oil? What is Low smoke oil for Two Stroke Engines? Two Stroke Engines emits the maximum pollutants compared to the four stroke Engines fitted in Cars & two/Three wheeler. The old generation 2T lubricant mixed with petrol and used in two Wheeler contributes more than 70% of the pollutants emitted from the Engines. As the emission norms become stringent, efforts are to reduce the harmful emission from two Wheeler. Only way to reduce the emission from two wheeler is to use the right quality of the 2T oil. By careful selection of the base oil mixed with the right quality and quantity of Synthetic oil and the right blend of performance additives, the emission level can be greatly reduced. Japanese Automobile Standards Organisation is the forerunner in setting standards for two strokes Engine Oil. Their FC specification stipulates a Smoke Index of minimum 80 so that very little pollutants is emitted from the two stroke Engines. Use of an oil meeting the specification requirement of JASO FC will reduce substantially the pollutants emitted by two wheelers. To control the emission from the two Wheeler, The Supreme Court of India allows only JASO FC grade of oil is marketed in India with effect from 1-04-1999. The Two Wheeler user can show their concern to save the Environment by necessarily usin\nTwo Wheeler / 3 Wheeler engines are air-cooled engines unlike the passenger car engines which are cooled by water or by a coolant. The Engines are effectively cooled by the air drag across the engines while the vehicle is in motion. The Engine operating temperatures exponentially shoots up when the vehicle speeds are reduced or the vehicle is stopped since the air drag drastically reduces under these conditions as encountered in a typical city operating conditions. Secondly these vehicles use wet clutch mechanism and the same engine oil lubricates the engine, the wet clutch and the gears. So oil with high Friction Modifier used in Engine Oil will lead to clutch slippage. The Oil used for Four Stroke engines, Two Wheeler / Three Wheeler, need to take care of the higher temperature operating condition as well as it should have controlled friction characteristics to take care of the wet clutch requirement. At the same time it should have reduced friction characteristics as required by the Engines & gears. GLIDE 4T Oil is specially developed to meet these special requirements of this class of vehicles.\nThe development in the Vehicle Engine Technology is moving in a fast pace to take care of the higher power, compact size and the latest emission requirement. Due to these continuos development in the field of Engine Technology, the speed of the engines increases, the oil sump capacity becomes lower & lower, after treatment of the exhaust gases has been introduced (Catalytic Converter, particulate filter etc.). To keep in pace with the development in the Engine technology, the oil performance level also has to be continuously improved to meet the additional requirement. American Petroleum Institute (API) and various International organisation sets standard for the Engine Oil to suit the requirement of the development in Engine Technology. API Oils are classified as SA, SB,….SF, SG, SJ for Petrol Engines and as CA, CB,…. CD, CF4, CG4, CH4 for Diesel Engines. Bharat Petroleum Corporation Ltd., markets oil meeting the latest API & Other international & Indian Standards for use in all type of petrol & Diesel engines.\nindustrial lubricants distributors in Kerala, L and T Lubricants distributors in Kerala, ernakulam, kochi, cochin, pathanamthitta, kottayam, idukki, industrial lubricants distributors, L and T Lubricants distributors, kerala, L and T Lubricants distributors in Kerala, L and T Lubricants, L & T Lubricants distributors, L and T Lubricants distributors\nScroll to Top\nMAK Lubricants distributors in kerala, ernakulam, kochi, cochin, pathanamthitta, kottayam, idukki\nLubricants distributors in Kerala, ernakulam, kochi, cochin, pathanamthitta, kottayam, idukki\noil distributors in kerala, ernakulam, kochi, cochin, pathanamthitta, kottayam, idukki\nParakkattu Agencies in kerala, ernakulam, kochi, cochin, pathanamthitta, kottayam, idukki\nMAK Lube distributors in kerala, ernakulam, kochi, cochin, pathanamthitta, kottayam, idukki\nhydrol 68 oil distributors in kerala, ernakulam, kochi, cochin, pathanamthitta, kottayam, idukki\nmak oil distributor in kerala, ernakulam, kochi, cochin, pathanamthitta, kottayam, idukki\nindustrial lubricants distributors in kerala, ernakulam, kochi, cochin, pathanamthitta, kottayam, idukki\nAuto Lubricants distributors in kerala, ernakulam, kochi, cochin, pathanamthitta, kottayam, idukki\nL & T Lubricants distributors in kerala, ernakulam, kochi, cochin, pathanamthitta, kottayam, idukki", "domain": "chemistry", "round": 3} +{"url": "http://www.abcam.com/p21-antibody-epr362-ab109520.html", "date": "2017-01-23T02:58:58Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-04/segments/1484560281746.82/warc/CC-MAIN-20170116095121-00275-ip-10-171-10-70.ec2.internal.warc.gz", "language_score": 0.8734975457191467, "token_count": 1348, "dump": "CC-MAIN-2017-04", "global_id": "webtext-fineweb__CC-MAIN-2017-04__0__75357451", "lang": "en", "text": "For the best experience on the Abcam website please upgrade to a modern browser such as Google Chrome\nSynthetic peptide (the amino acid sequence is considered to be commercially sensitive) within Human p21 aa 1-100. The exact sequence is proprietary.\nWe are constantly working hard to ensure we provide our customers with best in class antibodies. As a result of this work we are pleased to now offer this antibody in purified format. We are in the process of updating our datasheets. The purified format is designated ‘PUR’ on our product labels. If you have any questions regarding this update, please contact our Scientific Support team.\nThis product is a recombinant rabbit monoclonal antibody.\nProduced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.\nA trial size is available to purchase for this antibody.\nOur Abpromise guarantee covers the use of ab109520 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\nFor unpurified use at 1/50 - 1/100.\n|WB||1/1000 - 1/10000. Predicted molecular weight: 21 kDa.|\n|IP||1/10 - 1/100.|\n|IHC-P||1/100 - 1/250. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.\nSee protocols (link: http://www.abcam.com/protocols/ihc-antigen-retrieval-protocol).\nImmunocytochemistry/Immunofluorescence analysis of MCF7 cells labelling p21 with purified ab109520 at 1/1000. Cells were fixed with 4% paraformaldehyde and permeabilized with 0.1% Triton X-100. ab150077, an Alexa Fluor® 488-conjugated goat anti-rabbit IgG (1/500) was used as the secondary antibody. DAPI (blue) was used as the nuclear counterstain. ab7291, a mouse anti-tubulin (1/1000) and ab150120, an Alexa Fluor® 594-conjugated goat anti-mouse IgG (1/500) were also used.\nControl 1: primary antibody (1/1000) and secondary antibody, ab150120, an Alexa Fluor® 594-conjugated goat anti-mouse IgG (1/500).\nImmunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human papillary carcinoma of the thyroid gland tissue labelling p21 with unpurified ab109520 at a dilution of 1/100.\nBlocking and dilution buffer: 5% NFDM/TBST.\nBlocking and dilution buffer: 5% NFDM/TBST.\nImmunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human thyroid carcinoma tissue labelling p21 with purified ab109520 at 1/100. Heat mediated antigen retrieval was performed using Tris/EDTA buffer pH 9. ab97051, a HRP-conjugated goat anti-rabbit IgG (H+L) was used as the secondary antibody (1/500). Negative control using PBS instead of primary antibody. Counterstained with hematoxylin.\nImmunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human cervical carcinoma tissue labelling p21 with unpurified ab109520 at a dilution of 1/100.\nUnpurified ab109520 staining p21 in MCF-7 cells by ICC/IF (Immunocytochemistry/immunofluorescence). Cells were fixed with paraformaldehyde, permeabilized with Triton X-100 and blocked with 1% serum for 1 hour at 22°C. Samples were incubated with primary antibody (1/100 in PBS + 1% goat serum + 1% BSA) for 16 hours at 4°C. A goat anti-rabbit Alexa Fluor® 488 (1/500) was used as the secondary antibody.\nOverlay histogram showing HeLa cells stained with unpurified ab109520 (red line). The cells were fixed with 80% methanol (5 min) then permeabilized with 0.1% PBS-Tween 20 for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (unpurified ab109520, 1/100) for 30 min at 22ºC. The secondary antibody used was Alexa Fluor® 488 goat anti-rabbit IgG (H&L) (ab150081) at 1/2000 dilution for 30 min at 22ºC. Isotype control antibody (black line) was rabbit IgG (monoclonal) (ab172730, 1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control.\nAcquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter.\nab109520 (purified) at 1/50 immunoprecipitating p21 in HEK293 whole cell lysate.\nLane 1 (input): HEK293 whole cell lysate (10µg)\nLane 2 (+): ab109520 + HEK293 whole cell lysate (10µg).\nLane 3 (-): Rabbit monoclonal IgG (ab172730) instead of ab109520 in HEK293 whole cell lysate.\nFor western blotting, ab131366 VeriBlot for IP (HRP) was used as the secondary antibody (1/1500).\nBlocking buffer and concentration: 5% NFDM/TBST.\nDiluting buffer and concentration: 5% NFDM /TBST.", "domain": "chemistry", "round": 3} +{"url": "https://allaboutblood.wordpress.com/2014/10/09/tumour-lysis-syndrome/", "date": "2023-04-02T05:33:46Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-14/segments/1679296950383.8/warc/CC-MAIN-20230402043600-20230402073600-00613.warc.gz", "language_score": 0.8978115320205688, "token_count": 1650, "dump": "CC-MAIN-2023-14", "global_id": "webtext-fineweb__CC-MAIN-2023-14__0__142039228", "lang": "en", "text": "Rapid tumour lysis can release harmful metabolites at a rate that exceeds the kidney’s excretory capacity resulting in a metabolic syndrome known as tumour lysis syndrome (TLS). TLS is a complex of hyperkalaemia, hyperuricaemia, hypocalcaemia, hyperphosphatamia and lactic acidosis. It is most commonly seen in high-grade malignancies (leukaemia, high grade lymphomas and testicular tumours), usually following therapy but occasionally spontaneously.\nDefinition of TLS\nBiochemical changes precede clinical manifestations of TLS. TLS is classified into laboratory TLS (LTSL) or clinical TLS (CTLS). The diagnosis of LTLS requires an abnormality in two or more of the following, occurring within 3 days before or 7 days after initiation of chemotherapy:\n- Uric acid >8 mg/dL or 25% increase from baseline\n- Potassium >6 meq/L or 25% increase from baseline\n- Phosphate >4.5 mg/dL or 25% increase from baseline\n- Calcium <7 mg/dL or 25% decrease from baseline\nClinical TLS is defined as LTLS plus one or more of the following:\n- Increased serum creatinine (1.5 times upper limit of normal)\n- Cardiac arrhythmia or sudden death\nAetiology of TLS\nTLS is seen when the renal capacity to excrete products of tumour lysis is overwhelmed. This may happen under the following circumstances:\n- The metabolites are released too fast as may be seen with tumours that are very sensitive to chemotherapy.\n- The metabolites are released in a large amount as may happen with a large tumour.\n- The kidney function is compromised.\nThe common tumours associated with tumour lysis syndrome are lymphoid malignancies (Burkitt’s lymphoma and other high grade lymphomas, acute lymphoblastic leukaemia) and other acute leukaemias. These tumours have a high proliferation rate and are very sensitive to chemotherapy. As leukaemias do not present with a tumour the malignant cell load in leukaemias is not fully appreciated. The bone marrow is about 4% the body mass. A 72kg patient who has 30% blasts would have about one kg of tumour in the bone marrow. Lymphoid neoplasia also involve the spleen and liver and have a greater cell load than myeloid leukaemia. Lymphoid leukaemias are also more sensitive to chemotherapy than myeloid leukaemias and undergo a more rapid lysis. This makes patients of high grade lymphoid malignancy most prone to TLS.\nTLS is rare but has been described in solid tumours like testicular tumours and small cell lung cancers, breast carcinoma and neuroblastomas. Usually low grade malignancies like chronic lymphocytic leukaemia and other low grade lymphomas are not associated with TLS because they do not undergo rapid lysis with therapy. There have been reports of patients with malignancies that have a negligible risk of TLS on conventional chemotherapy developing TLS when treated with purine analogues like fludarabine and cladribine and with targeted agents. These include:\n- Treatment of chronic lymphocytic leukaemia and low grade lymphoma with fludarabine\n- Refractory chronic lymphocytic leukaemia treated with cladribine\n- Multiple myeloma treated with bortezomib\n- Chronic myelocytic leukaemia treated with imatinib.\n- Gastrointestinal stromal tumour treated with imatinib (Sarcoma. 2007;2007:82012)\n- Renal Cell carcinoma treated with sunitinib (Invest New Drugs. 2010 Oct;28(5):690-3).\nAll the above situations are characterised by a rapid tumour response accompanied by a release of metabolites at a rate the kidneys can not cope up with.\nOne needs to keep the possibility of TLS in every patient with a large tumour and/or a chemosensitive tumour treated with very active drugs. Many of these patients present with non-specific manifestations.\nCell lysis releases intracellular contents including potassium, phosphates, purines and lactic acid. Purines are metabolised to uric acid by a pathway needing xanthine oxidase. Uric acid precipitated in the renal tubules causing renal failure. Phosphate released by cells chelates calcium causing hypocalcaemia. Precipitations of calcium phosphate in the kidney adds to the renal failure caused by precipitation of uric acid. Hypocalcaemia causes tetany, muscle cramps, rarely seizures and enhances the arrhythmogenic effect of hyperkalaemia. Lactic acid release causes acidosis. Hyperkalaemia resulting from release of intracellular potassium causes arrhythmias and muscle cramps. Renal failure increases hyperkalaemia and hypocalcaemia enhances the arrhythmogenic effect of hyperkalaemia.\nMany patients are diagnosed with only laboratory TLS on tests done as a part of initial evaluation. The symptoms when present are non-specific and include nausea, vomiting, confusion, oliguriua, bronchospasm and seizures. Patients at increased risk of developing TLS include\n- High volume disease: Patines with high blood counts and/or pronounced organomegaly or elevated LDH are more prone to TLS.\n- Patients with pretreatment elevation of uric acid\n- Patients with compromised renal function\nEstablished TLS is a serious disease. The possibility of TLS must be considered in every patients with high volume disease and preventive measures instituted. These include\n- Hydration with about 3000ml/day should be started 24 hours before starting chemotherapy. Alkalinization of urine to promote ionisation of uric acid and improve it’s solubility is controversial. The pKa of uric acid is 5.4. About 90% of uric acid exists as sodium urate at a pH of 6.5. Increasing the pH any further will not increase solubility significantly. On the other hand calcium phosphate becomes less soluble with increasing pH. Alkalinization can cause precipitation of calcium phosphate in the tubules. Alkalinization can also worsen hypocalcaemia.\n- Measure to reduce uric acid: Purines are converted to xanthine. Xanthine is converted to uric acid by xanthine oxidase. Allopurinol inhibits xanthine oxidase and prevents conversion of xanthine to uric acid. Xanthine is more soluble than uric acid and does not precipitate. Allopurinol prevents formation of uric acid. It has no effect on the elimination of uric acid. Urate oxidase converts uric acid to soluble metabolites and may be used in patients who do not respond to allopurinol or those who thought to be at high risk of TLS.\n- Delaying chemotherapy in patients to give time for correction of defects where possible\n- Close monitoring of patients early in induction therapy for metabolic defects and instituting therapy to correct these defects at the earliest.\nThe management of established TLS is the treatment of the metabolic anomalies. Hyperkalaemia is treated with\n- Potassium restriction\n- Aggressive hydration with the use of loop diuretics if needed to promote elimination of potassium\n- Use of cataion exchange resins to decrease absorption of potassium\n- Other measures include use of calcium gluconate, sodium bicarbonate, glucose-insulin drip, beta-2 agonist aerosols and dialysis.\nHyperphosphataemia is treated with aggressive hydration, phosphate restriction, oral phosphate binders and dialysis if necessary.\nHyperuricaemia is treated with allopurinol, urate oxidase and hydration.", "domain": "chemistry", "round": 3} +{"url": "http://www.researchgate.net/researcher/58636134_Jerome_Ausseil/", "date": "2013-12-05T22:43:43Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2013-48/segments/1386163048362/warc/CC-MAIN-20131204131728-00068-ip-10-33-133-15.ec2.internal.warc.gz", "language_score": 0.9402713179588318, "token_count": 368, "dump": "CC-MAIN-2013-48", "global_id": "webtext-fineweb__CC-MAIN-2013-48__0__26228442", "lang": "en", "text": "[show abstract] [hide abstract]\nABSTRACT: The cytotoxicity of oxidized LDL (OxLDL) towards different cell types of the arterial wall results in atherosclerotic plaque fissuring or rupture. The effects of OxLDL on cyclins A, E and D1 levels were investigated in human fibroblasts. A 24h incubation with Cu(2+)-oxidized (CuLDL) or monocyte-oxidized LDL (M-LDL), within the range of 10-50μg ApoB/ml, increased the intracellular level of cyclin A, both in the nuclear and in the cytoplasmic fraction. This increase is due to a stimulation of cyclin A mRNA synthesis, and cycloheximide had a preventive effect. The CuLDL-induced rise in cyclin A was accompanied by an augmentation of reactive oxygen species ROS and of lipid peroxidation end products. Furthermore, this effect was reproduced by the lipid extract of CuLDL and prevented by the antioxidant vitamin E, demonstrating the role of oxidized lipids and the involvement of oxidative stress. In addition, the use of specific inhibitors indicated that the increase in cyclin A involved ERK/JNK kinases and NFkappaB transcription factor. The augmentation of cyclin A was observed not only in fibroblasts but also in other cell types such as macrophages, T lymphocytes, endothelial and smooth muscle cells. Since cyclin A has been shown to be involved in cell cycle arrest, the described phenomenon might be related to the harmful effect of OxLDL, leading to plaque rupture.\nAtherosclerosis 06/2011; 218(2):308-13. · 3.71 Impact Factor", "domain": "chemistry", "round": 3} +{"url": "https://www.mvorganizing.org/why-is-radiometric-dating-not-accurate/", "date": "2021-12-06T17:59:07Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-49/segments/1637964363309.86/warc/CC-MAIN-20211206163944-20211206193944-00502.warc.gz", "language_score": 0.9126097559928894, "token_count": 1144, "dump": "CC-MAIN-2021-49", "global_id": "webtext-fineweb__CC-MAIN-2021-49__0__62347636", "lang": "en", "text": "Why is radiometric dating not accurate?\nBecause carbon-14 decays relatively rapidly compared to other isotopes, it can only be used to date things that are less than 60,000 years old. Anything older would have so little carbon-14 left that you couldn’t accurately measure it.\nWhat are limitations of radioactive dating?\nLimitations of Radiometric Dating The material being dated must have measurable amounts of the parent and/or the daughter isotopes. Ideally, different radiometric techniques are used to date the same sample; if the calculated ages agree, they are thought to be accurate.\nWhat is the problem with using radiocarbon dating?\nInorganic materials can’t be dated using radiocarbon analysis, and the method can be prohibitively expensive. Age is also a problem: Samples that are older than about 40,000 years are extremely difficult to date due to tiny levels of carbon-14. Over 60,000 years old, and they can’t be dated at all.\nWhy fossil dating is inaccurate?\nBut scientists have long recognized that carbon dating is subject to error because of a variety of factors, including contamination by outside sources of carbon. Therefore they have sought ways to calibrate and correct the carbon dating method.\nAre there flaws in carbon dating?\nCosmic rays and changes in Earth’s climate can cause irregularities in the amount of Carbon-14 in the atmosphere. Though it’s biggest, the calibration problem is not the only flaw of radiocarbon dating.\nWhy can’t carbon 14 dating be used for ages 50000 years and older?\nOver time, carbon-14 decays radioactively and turns into nitrogen. Because of the short length of the carbon-14 half-life, carbon dating is only accurate for items that are thousands to tens of thousands of years old. Most rocks of interest are much older than this.\nHow far back can carbon dating?\nAs a rule, carbon dates are younger than calendar dates: a bone carbon-dated to 10,000 years is around 11,000 years old, and 20,000 carbon years roughly equates to 24,000 calendar years. The problem, says Bronk Ramsey, is that tree rings provide a direct record that only goes as far back as about 14,000 years.\nWhat can carbon dating be used to determine the age of?\nRadiocarbon dating (also referred to as carbon dating or carbon-14 dating) is a method for determining the age of an object containing organic material by using the properties of radiocarbon, a radioactive isotope of carbon.\nCan I do carbon dating at home?\nAncient fossil fuels may limit carbon, as a diy carbon dating. Together carbon–12 and tech; engineering and more recently is based. An isotope of all of 14c can be used scientific dating experiment at home page of remaining carbon-14 they can represent either mixtures of.\nCan you carbon date a living human?\nA living human being exchanges so much material with the environment that it’s not feasible in the standard way. Nope. Carbon dating works by measuring the ratio of Carbon-14 to Carbon-12. These C14 atoms are radioactive and will decay at a know rate back to Nitrogen atoms.\nWhy is carbon dating not useful for dating fossils from millions of years ago?\nCarbon dating cannot be used on most fossils, not only because they are almost always too old, but also because they rarely contain the original carbon of the organism. Also, many fossils are contaminated with carbon from the environment during collection or preservation proceedures.\nHow do we know the earth is 4.5 billion years old?\nBy dating the rocks in Earth’s ever-changing crust, as well as the rocks in Earth’s neighbors, such as the moon and visiting meteorites, scientists have calculated that Earth is 4.54 billion years old, with an error range of 50 million years.\nWhat is the first earth age?\nabout 4.54 billion years\nWill the earth last forever?\nHowever, the long-term trend is for plant life to die off altogether. By that point, all life on the Earth will be extinct. The most probable fate of the planet is absorption by the Sun in about 7.5 billion years, after the star has entered the red giant phase and expanded beyond the planet’s current orbit.\nWhat is the most likely cause of human extinction?\nThe Future of Humanity Institute also states that human extinction is more likely to result from anthropogenic causes than natural causes.\n- Artificial intelligence.\n- Environmental disaster.\n- Experimental technology accident.\n- Global warming.\n- Mineral resource exhaustion.\nHow many species have gone extinct because of humans?\nSince the 16th century, humans have driven at least 680 vertebrate species to extinction, including the Pinta Island tortoise. The last known animal of this subspecies, a giant tortoise nicknamed Lonesome George, died at the Galapagos National Park in Ecuador in 2012.\nHow many species die a day?\nWhat animals are going extinct in 2020?\n- Species that went extinct in 2020.\n- Splendid poison frog.\n- Jalpa false brook salamander.\n- Simeulue Hill myna.\n- Lost shark.\n- Smooth handfish.\n- Lake Lanao freshwater fish.\n- Chiriqui harlequin frog.", "domain": "chemistry", "round": 3} +{"url": "https://mcec-researchcenter.nl/mcec-consortium-celebrates-five-year-anniversary/", "date": "2023-12-07T22:23:21Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100705.19/warc/CC-MAIN-20231207221604-20231208011604-00886.warc.gz", "language_score": 0.9253997802734375, "token_count": 509, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__139175735", "lang": "en", "text": "The Center for Multiscale Catalytic Energy Conversion (MCEC) celebrated its fifth anniversary with a scientific symposium on catalysis at De Fabrique in Utrecht.\nCollaborations and Impact\nBecause catalysis can be studied at different length scales, different scientific disciplines are involved in catalysis research. The main objective of MCEC is that chemists, physicists materials scientists and chemical engineers work together, both within and outside their own discipline, to find answers to important questions in the field of energy transition. Therefore, on 29 November this year, MCEC organized a scientific symposium where the MCEC community presented the latest state of their research to each other.\nDr. Mathieu Odijk (University of Twente) kicked off the symposium with his research into micro-level catalysis by means of microreactors. Next, a new member of the MCEC scientific advisory board, Prof. Raffaella Ocone (Heriot-Watt University), spoke about improvements in chemical processes on an industrial scale. The following presentation by Prof. Jens Nørskov (Technical University of Denmark) gave inspiring insights to answer an important question in catalysis research: ‘How do we make new catalysts for N2 activation?\nDr. Robin Geitenbeek (Utrecht University), Dr. Hai Le The (Twente University) and Katarina Stanciakova (Utrecht University) then presented their PhD projects from the first phase of MCEC. Scientific director Prof. Bert Weckhuysen (Utrecht University) concluded the day with a lecture on how spectroscopy and microscopy can be used to reveal chemical processes in catalysts.\nSecond phase of MCEC\nWith this symposium the first phase of MCEC came to an end. MCEC provides 40 positions for PhD students and postdocs in two phases of five years, whereby it can leave its ma\nThe MCEC consortium is a gravity programme that was granted funding of ~ 32 million euro for personnel and facilities by NWO in 2014 for a maximum of ten years. This means that over the next five years, MCEC will be able to continue working on groundbreaking research in the field of catalysis.rk on Dutch catalysis research and thereby contribute to the further international profiling of this important area of research. Furthermore, the community currently consists of 54 staff members, a management team of 7 professors and a scientific advisory committee of 8 leading international scientists.\n17 December 2019", "domain": "chemistry", "round": 3} +{"url": "https://researchrepository.ucd.ie/handle/10197/9813", "date": "2022-01-27T20:20:10Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-05/segments/1642320305288.57/warc/CC-MAIN-20220127193303-20220127223303-00357.warc.gz", "language_score": 0.7804478406906128, "token_count": 688, "dump": "CC-MAIN-2022-05", "global_id": "webtext-fineweb__CC-MAIN-2022-05__0__222214472", "lang": "en", "text": "Nanostructured apatite-mullite glass-ceramics for enhanced primary human osteoblast cell response\nFiles in This Item:\n|Download||Dunne_et_al_ML_2017_Manuscript_RR.docx||1.26 MB||Microsoft Word|\n|Title:||Nanostructured apatite-mullite glass-ceramics for enhanced primary human osteoblast cell response||Authors:||Dunne, Conor F.; Cooke, Gordon; Keane, S.; de Faoite, Daithí; Donnelly, S.C.; Stanton, Kenneth T.||Permanent link:||http://hdl.handle.net/10197/9813||Date:||11-Dec-2017||Online since:||2019-04-04T09:37:32Z||Abstract:||This work investigates the difference in viability of primary human foetal osteoblast cells on a glass-ceramic surface with nanoscale topography relative to viability on a smooth glass-ceramic surface containing a bioactive phase. Apatite-mullite glass-ceramics containing bioactive fluorapatite (Ca10(PO4)6F2) and bioinert mullite (Si2Al6O13) were synthesised and subsequent heat-treatment was optimised to form nano-sized fluorapatite crystals. Etching was used to selectively remove the bioactive phase, producing a surface with disordered nanoscale topography. Cells were seeded onto a smooth polished glass-ceramic substrate with the bioactive phase intact, an etched nanostructured glass-ceramic with the bioactive phase removed, and a borosilicate glass control. Cell viability after 24 h and 48 h was significantly greater on the nanostructured surface compared to the smooth bioactive surface, while cell viability at both time points was significantly greater on both nanostructured and smooth bioactive surfaces compared to the control.||Funding Details:||Higher Education Authority||Type of material:||Journal Article||Publisher:||Elsevier||Journal:||Materials Letters||Volume:||214||Start page:||268||End page:||271||Copyright (published version):||2017 Elsevier||Keywords:||Glass-ceramic; Bioceramics; Nanocrystalline materials; Cell response||DOI:||10.1016/j.matlet.2017.12.051||Language:||en||Status of Item:||Peer reviewed||This item is made available under a Creative Commons License:||https://creativecommons.org/licenses/by-nc-nd/3.0/ie/|\n|Appears in Collections:||Mechanical & Materials Engineering Research Collection|\nShow full item record\nIf you are a publisher or author and have copyright concerns for any item, please email firstname.lastname@example.org and the item will be withdrawn immediately. The author or person responsible for depositing the article will be contacted within one business day.", "domain": "chemistry", "round": 3} +{"url": "http://www.abcam.com/edc4-antibody-ab72410.html", "date": "2017-03-26T13:17:08Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-13/segments/1490218189239.16/warc/CC-MAIN-20170322212949-00096-ip-10-233-31-227.ec2.internal.warc.gz", "language_score": 0.8316853046417236, "token_count": 419, "dump": "CC-MAIN-2017-13", "global_id": "webtext-fineweb__CC-MAIN-2017-13__0__270842126", "lang": "en", "text": "The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\nUse at 2-5 µg/mg of lysate.\nApplication notesIs unsuitable for WB.\nFunctionIn the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2. Enhances the catalytic activity of DCP2 (in vitro).\nSequence similaritiesBelongs to the WD repeat EDC4 family. Contains 4 WD repeats.\nPost-translational modificationsPhosphorylated upon DNA damage, probably by ATM or ATR.\nHuman enhancer of decapping large subunit antibody\nRCD 8 antibody\nAnti-EDC4 antibody images\nImmunoprecipitation - EDC4 antibody (ab72410)\nImmunoprecipitation/ Western Blot of EDC4.\nLane 1: ab72410 at 3µg/mg whole cell lysate.\nLane 2: Control IgG.\nAnother antibody to EDC4 was used at 1µg/ml for WB.\nWhole cell lysate from Hela cells at 1mg for IP, 20% of IP loaded.\nChemiluminescence with an exposure time of 3 seconds.\nReferences for Anti-EDC4 antibody (ab72410)\nhas not yet been referenced specifically in any publications.\nPublishing research using ab72410? Please let us know so that we can cite the reference in this datasheet.\nConcentration of lot no. is\nConcentration not available for this lot.\nFind concentration of your lot:\nPlease note: All products are \"FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE\"", "domain": "chemistry", "round": 3} +{"url": "https://insights.ovid.com/glyco/201501000/00002513-201501000-00012", "date": "2020-02-21T19:20:47Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-10/segments/1581875145534.11/warc/CC-MAIN-20200221172509-20200221202509-00337.warc.gz", "language_score": 0.9172288179397583, "token_count": 403, "dump": "CC-MAIN-2020-10", "global_id": "webtext-fineweb__CC-MAIN-2020-10__0__165741857", "lang": "en", "text": "|| Checking for direct PDF access through Ovid\nN-Acetylneuraminate lyase synthase (NeuB; E.C. 22.214.171.124) is a key enzyme in pathogenic microorganisms for producing N-acetylneuraminic acid through the irreversible condensation of N-acetylmannosamine (ManNAc) and phosphoenolpyruvate (PEP). However, nothing is known about this enzyme in non-pathogenic bacteria. This paper describes, for the first time, one of the two putative N-acetylneuraminate synthases from the halophilic non-pathogenic gamma-proteobacterium Idiomarina loihiensis NeuB1 (IlNeuB1). The obtained 95-kDa dimeric enzyme showed maximal activity at pH 7.0 and 40°C and was more stable at pH 8.0 (8 h half-life) than the previously described NeuB. Its catalytic efficiency towards ManNAc and PEP was 10- and 40-fold higher, respectively, than that determined for Campylobacter jejuni NeuB, but only half that found for Neisseria meningitidis NeuB towards PEP. The phylogenetic and structural analyses of NeuB enzymes revealed the new domain architecture 4 has no cystathionine-β-synthase domain (cystathionine-β-synthetase domain), unlike domain architecture 3. In addition, 10 conserved blocks (I–X) were found, and surprisingly, this study showed that the arginine essential for catalysis that is present in antifreeze-like domain (block X) was not fully conserved in NeuB, but is replaced by a serine in a long sequence (>700 residues) NeuB, such as that existing in domain architectures 3 and 4.", "domain": "chemistry", "round": 3} +{"url": "https://www.cellsignal.com/products/primary-antibodies/phospho-numa-ser395-antibody/3429", "date": "2020-06-01T09:11:56Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-24/segments/1590347415315.43/warc/CC-MAIN-20200601071242-20200601101242-00515.warc.gz", "language_score": 0.8934037685394287, "token_count": 848, "dump": "CC-MAIN-2020-24", "global_id": "webtext-fineweb__CC-MAIN-2020-24__0__15350487", "lang": "en", "text": "Western blot analysis of extracts from M059K cells, untreated or UV-treated, using Phospho-NuMA (Ser395) Antibody.\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.\nFor western blots, incubate membrane with diluted primary antibody in 5% w/v BSA, 1X TBS, 0.1% Tween® 20 at 4°C with gentle shaking, overnight.\nNOTE: Please refer to primary antibody datasheet or product webpage for recommended antibody dilution.\nFrom sample preparation to detection, the reagents you need for your Western Blot are now in one convenient kit: #12957 Western Blotting Application Solutions Kit\nNOTE: Prepare solutions with reverse osmosis deionized (RODI) or equivalent grade water.\nLoad 20 µl onto SDS-PAGE gel (10 cm x 10 cm).\nNOTE: Volumes are for 10 cm x 10 cm (100 cm2) of membrane; for different sized membranes, adjust volumes accordingly.\n* Avoid repeated exposure to skin.\nposted June 2005\nrevised November 2013\nReprobing of an existing membrane is a convenient means to immunoblot for multiple proteins independently when only a limited amount of sample is available. It should be noted that for the best possible results a fresh blot is always recommended. Reprobing can be a valuable method but with each reprobing of a blot there is potential for increased background signal. Additionally, it is recommended that you verify the removal of the first antibody complex prior to reprobing so that signal attributed to binding of the new antibody is not leftover signal from the first immunoblotting experiment. This can be done by re-exposing the blot to ECL reagents and making sure there is no signal prior to adding the next primary antibody.\nNOTE: Prepare solutions with reverse osmosis deionized (RODI) or equivalently purified water.\nposted June 2005\nrevised October 2016\nProtocol Id: 10\nPhospho-NuMA (Ser395) Antibody detects endogenous levels of NuMA protein only when phosphorylated at Ser395.Species Reactivity:\nPolyclonal antibodies are produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Ser395 of human NuMA. Antibodies are purified using protein A and peptide affinity chromatography.\nThe nuclear mitotic apparatus protein (NuMA) is a coiled coil protein involved in the formation and maintenance of the mitotic spindle. NuMA plays a role in chromatin organization during interphase, which influences mammary epithelial differentiation (1,2). During apoptosis, carboxy-terminal cleavage of NuMA may amplify signaling in the cell death pathway (2). NuMA is phosphorylated at numerous sites, with phosphorylation at Ser395 occurring in an ATM/ATR-dependent manner in response to DNA damage (3,4).\nPhosphorylation at Thr2055 by CDK1 is required for spindle pole association of NuMA at the onset of mitosis. Dephosphorylation by PPP2CA leads to enhancement of NuMA at the cell cortex in anaphase and proper cell-cycle progression (5,6).\nPhospho-NuMA (Ser395) Antibody is directed at a site that was identified at Cell Signaling Technology (CST) using PhosphoScan®, CST's LC-MS/MS platform for modification site discovery. Phosphorylation at Ser395 was discovered using an ATM/ATR substrate antibody and was shown to be induced by UV treatment. Please visit PhosphoSitePlus®, CST's modification site knowledgebase, at www.phosphosite.org for more information.\nExplore pathways + proteins related to this product.\nCell Signaling Technology is a trademark of Cell Signaling Technology, Inc.", "domain": "chemistry", "round": 3} +{"url": "http://immunologie-labor.com/ZM-CI/zmci_paragon.php?lang=de&content=79&rubrik=27", "date": "2020-02-28T05:28:36Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-10/segments/1581875147054.34/warc/CC-MAIN-20200228043124-20200228073124-00514.warc.gz", "language_score": 0.9121883511543274, "token_count": 263, "dump": "CC-MAIN-2020-10", "global_id": "webtext-fineweb__CC-MAIN-2020-10__0__65328436", "lang": "en", "text": "Preembedding immuno-staining for electron microscopy\nWolf D. Kuhlmann\nDivision of Radiooncology, Deutsches Krebsforschungszentrum, 69120 Heidelberg, Germany\nThe localization of intracellular antigens by labeled antibodies is governed by their penetrability. Studies with aldehyde fixed cell suspensions and various marker molecules of known molecular weight have shown that molecules of 80,000 daltons and more do not penetrate cell membranes or do so only sluggishly. Enzymatic predigestion of cell surface material improved penetration, however, the total number of stained cells remained low. In order to overcome penetration problems, treatments of aldehyde fixed cells f.e. with saponin, Tween and other detergents were examined. Yet, no convincing results could be obtained with hand-cut tissue fragments.The best results were obtained with thick frozen sections from well-fixed specimens. The adoption of cryomicrotomy to preembedment immunohistology is not difficult, and a typical protocol is described for the immunoperoxidase detection of alpha-1-fetoprotein in rat liver (fetal liver; regenerating liver after injury; hepatoma bearing liver).", "domain": "chemistry", "round": 3} +{"url": "http://www.humpath.com/spip.php?article1125", "date": "2017-05-29T05:39:53Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-22/segments/1495463612018.97/warc/CC-MAIN-20170529053338-20170529073338-00231.warc.gz", "language_score": 0.6557585597038269, "token_count": 487, "dump": "CC-MAIN-2017-22", "global_id": "webtext-fineweb__CC-MAIN-2017-22__0__223114206", "lang": "en", "text": "Monday 6 October 2003\nThe cytochrome c oxidase (COX) are the terminal enzymes in the respiratory chain. Cytochrome c oxidase catalyzes the transfer of reducing equivalents from cytochrome c to molecular oxygen and pumps protons across the inner mitochondrial membrane.\nMitochondrial DNA encodes 3 COX subunits, I-III (MIM.516030), and nuclear DNA encodes 10 (MIM.123870).\n3 mitochondrial COX genes (COX1, COX2, COX3), one mitochondrial tRNA(ser) (MTTS1) (MIM.590080)\n|mitochondrial COX genes||COX1||COX2||COX3||COX4|\n|nuclear COX genes||COX5||COX6||COX7||COX8||COX9||COX10|\n|nuclear COX genes||COX11||COX12||COX13||COX14||COX15|\nDeficiencies in the activity of cytochrome c oxidases, COXs deficiency, mitochondrial respiratory chain complex IV deficiency (MIM.220110)\nCOX10 (mutations in progressive mitochondrial encephalopathy with proximal renal tubulopathy due to cytochrome C oxidase deficiency) (MIM.602125)\nCOX15 (mutations in early-onset fatal hypertrophic cardiomyopathy)\nSCO1 (17p12-12) (mutations in early-onset hepatic failure with neurologic disorder) (MIM.603644)\nSCO2 (22q13) (fatal infantile cardioencephalomyopathy due to cytochrome C oxydase deficiency (MIM.604272)\nfrequent cause of autosomal recessive mitochondrial disease in infants.\nCOX15 mutations in fatal infantile hypertrophic cardiomyopathy\nSCO2 mutations in fatal infantile cardioencephalomyopathy (MIM.604377)\nBarrientos A, Barros MH, Valnot I, Rotig A, Rustin P, Tzagoloff A. Cytochrome oxidase in health and disease.\nGene. 2002 Mar 6;286(1):53-63. PMID: 11943460", "domain": "chemistry", "round": 3} +{"url": "https://biovisi.com/supplier/24888-biovision/25567-anti-rad17-antibody", "date": "2020-10-22T00:23:07Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-45/segments/1603107878662.15/warc/CC-MAIN-20201021235030-20201022025030-00041.warc.gz", "language_score": 0.8367516398429871, "token_count": 421, "dump": "CC-MAIN-2020-45", "global_id": "webtext-fineweb__CC-MAIN-2020-45__0__69585581", "lang": "en", "text": "Target of this antibody:\nAlternative names of antibody target:\nCCYC, R24L, RAD24, HRAD17, RAD17SP, FLJ41520, RAD17\nRad17 is an essential component of cell cycle checkpoints activated by DNA damage and disruption of DNA replication. DNA lesions such as single- and double-strand breaks, inter- and intra-strand cross-links, and base modifications hamper transcription and replication, resulting in cell cycle arrest, apoptosis, and mutagenesis. Phosphorylation of Rad17 at Ser635 and Ser645 is a critical early event during checkpoint signaling in DNA damaged cells.\nClonality of antibody:\nThis antibody reacts with:\nHuman, mouse, rat\nSynthetic peptide surrounding amino acid 645 of human Rad17\nConcentration of antibody:\nForm of antibody:\nFormulation of this antibody:\n100 µg (0.5 mg/ml) affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.\nThis antibody has been succesfully tested for use in following methods:\nWestern blotting (0.5-4 µg/ml). However, the optimal concentrations should be determined individually. The antibody recognizes the mature forms of Rad17 (~55 kDa and ~45 kDa) of human, mouse and rat origins. Reactivity to other species has not been tested.\nShelf time: 12 months in temp.: -20 deg.C\nHow to handle this antibody:\nThe antibody solution should be gently mixed before use.\nThis antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.\nIf you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/recombinant-human-amino-terminal-enhancer-of-split-protein-ab104756.html", "date": "2018-09-20T15:04:55Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-39/segments/1537267156513.14/warc/CC-MAIN-20180920140359-20180920160759-00317.warc.gz", "language_score": 0.7995287775993347, "token_count": 290, "dump": "CC-MAIN-2018-39", "global_id": "webtext-fineweb__CC-MAIN-2018-39__0__184061494", "lang": "en", "text": "The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\n% SDS-PAGE. ab104756 is purified using conventional chromatography techniques.\nConcentration information loading...\nPreparation and Storage\nStability and Storage\nShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.\npH: 8.00 Constituents: 0.0154% DTT, 0.316% Tris HCl, 20% Glycerol\nAmino enhancer of split\nAmino terminal enhancer of split\nAmino-terminal enhancer of split\nGp130 associated protein GAM\nGp130-associated protein GAM\nGroucho-related protein 5\nProtein ESP 1\nTranscriptional corepressor. Acts as dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state. Essential for the transcriptional repressor activity of SIX3 during retina and lens development.\nFound predominantly in muscle, heart and Placenta. In fetal tissues, abundantly expressed in the heart, lung, kidney, brain and liver.", "domain": "chemistry", "round": 3} +{"url": "https://accountablescience.com/families-suffer-after-military-bases-pollute-drinking-water-in-3-states/", "date": "2023-06-07T08:34:33Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-23/segments/1685224653631.71/warc/CC-MAIN-20230607074914-20230607104914-00198.warc.gz", "language_score": 0.9684772491455078, "token_count": 634, "dump": "CC-MAIN-2023-23", "global_id": "webtext-fineweb__CC-MAIN-2023-23__0__138757795", "lang": "en", "text": "Families Suffer After Military Bases Pollute Drinking Water in 3 States\nAmerican families put a lot of trust in the government to keep their drinking water pure. But in at least three states, the government has been directly responsible for polluting the tap water.\nWithin the past few weeks, military bases in Iowa, Florida, and Hawaii have all had chemical spills that resulted in contaminated drinking water for military members and families living near the base.\nIn Sioux City, Iowa, an investigation revealed that an Iowa Air National Guard base was the source of the PFAS contamination. Sometimes referred to as “forever chemicals,” PFAS are chemicals commonly found in the production of non-stick products like Teflon and have been tied to cancers and other health risks. The city reported a PFAS reading of 8,610 parts per trillion at the base. The federal government requires a public disclosure for any PFAS detection above 70 parts per trillion.\nThere isn’t a factory in the area, so investigators turned to the base. They found that there were PFAS in the solution used in firefighting on the base.\nPFAS are difficult to clean out of a water supply. Most municipalities are not equipped with the proper purification tools needed to clean the water. As for the people in Sioux City, local water treatment facilities have said they intend to continue testing for PFAS to ensure the current contamination levels do not increase.\nIn Pensacola, Florida, the same problem was spotted. An investigation that started in 2019 finally concluded with the discovery that the National Air Station Pensacola was the main source of PFAS in the city’s water. The Navy announced the findings to local homeowners.\n“Sampling will be available to property owners within the sampling area at no cost. The Navy will do its best to keep the sampling results of individual properties confidential to the extent permitted by law. The Navy will provide bottled water for drinking and cooking to any property in the sampling area if their well contains drinking water with PFOA and/or PFOS above the EPA’s LHA. The Navy will continue to provide bottled water until a permanent solution is put in place,” the Navy stated in a letter mailed to residents.\nIn Hawaii, it wasn’t PFAS contamination that tainted the water. Instead, jet fuel leaked from a U.S. Navy base into an aquifer that supplies about 20% of Honolulu’s drinking water. According to the state’s health department, initial readings detected petroleum levels 350 times what is considered safe in drinking water. The oil spill resulted in more than 3,000 displaced military members and their families.\nMany families were outraged by the lack of transparency from the government during the initial days of the leak. At least 1,000 households and two schools had reported a gasoline-like smell coming from the water as early as November. Others reported digestive problems they believed were tied to the contamination.\nIn each of these instances, the government failed to keep the tap water safe. Families deserve transparency in their tap water purity.", "domain": "chemistry", "round": 3} +{"url": "https://seotoolmag.net/precision-engineering-manlys-48v-100ah-lithium-ion-battery/", "date": "2024-03-04T17:51:53Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707947476464.74/warc/CC-MAIN-20240304165127-20240304195127-00094.warc.gz", "language_score": 0.9166606068611145, "token_count": 520, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__69617827", "lang": "en", "text": "In the realm of advanced energy solutions, MANLY emerges as a trailblazer with its meticulously crafted 48V 100Ah Lithium-Ion Battery. Precision engineering meets cutting-edge technology in this powerhouse battery, setting a new benchmark for reliability, performance, and efficiency across various applications.\nThe MANLY 48v 100ah lithium ion battery stands out as a testament to the brand’s commitment to pushing the boundaries of energy storage. Engineered with precision, this battery caters to the needs of a diverse range of applications, from electric vehicles to renewable energy storage systems, providing a robust and consistent power source.\nAt the core of MANLY’s innovation is the lithium-ion technology that powers this exceptional battery. With a voltage rating of 48V and a high capacity of 100Ah, it delivers an impressive power output that meets the demands of power-hungry devices and systems. This makes the battery an ideal choice for industries and applications where reliability and performance are paramount.\nPrecision engineering is evident in the compact design of MANLY’s 48V 100Ah Lithium-Ion Battery. The carefully crafted form factor ensures that the battery packs a punch without compromising on size. This is particularly crucial for applications where space is a premium, allowing for seamless integration without sacrificing performance. The lightweight nature of the battery further enhances its versatility, making it suitable for a wide range of installations.\nOne of the standout features of this battery is its advanced energy management system. Precision-engineered algorithms optimize the distribution of power, ensuring that devices and systems receive the required energy efficiently. This not only extends the battery life but also contributes to overall system efficiency, making MANLY’s lithium-ion battery a reliable and sustainable choice.\nSafety is a paramount concern in the design of MANLY’s 48V 100Ah Lithium-Ion Battery. The battery is equipped with state-of-the-art safety features, including overcharge protection, thermal management, and short-circuit prevention. This ensures that users can trust the battery to operate safely and reliably in various environments.\nIn conclusion, MANLY’s 48V 100Ah Lithium-Ion Battery exemplifies precision engineering at its finest. As a versatile and powerful energy solution, it caters to the diverse needs of industries seeking reliable and high-performance batteries. MANLY continues to redefine the standards of energy storage with this innovative lithium-ion battery, showcasing the brand’s dedication to precision, performance, and safety in the realm of advanced energy solutions.", "domain": "chemistry", "round": 3} +{"url": "https://bnlvita.it/high-temperature-grease.html", "date": "2021-04-17T05:28:40Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-17/segments/1618038101485.44/warc/CC-MAIN-20210417041730-20210417071730-00578.warc.gz", "language_score": 0.7406913638114929, "token_count": 846, "dump": "CC-MAIN-2021-17", "global_id": "webtext-fineweb__CC-MAIN-2021-17__0__107641317", "lang": "en", "text": "high temperature food grade greases at Cromwell. Cromwell is UK's leading tools and MRO supplier, featuring the widest range of products from all leading brands.\nzALTIS SH 2 is a top of the range synthetic grease designed for factory fill and sealed-for-life applications. z Also suitable for lubrication of bearings, slides, racks subjected to high temperatures in dry and mildly humid environments, bearings of electric motors, generators, bearings of dryers, pumps, oven conveyors, and all other applications where rotation speeds and temperatures are high and/or low. z Always avoid contamination of the grease by dust and/or dirt when applying.\nJun 15, 2018 · Let us first understand the use of lubrication. A bearing without lubrication is incomplete. It is an integral part of the bearing. Following are the uses of the greasing- 1.\nGet Protection Up To 800°C+. Omega 35 is the ultimate high temperature grease. Widely used in in oven cars, kiln cars, ovens, foundries, steel mills, tooling, metal forming – Get Omegas renowned levels of protection at extreme temperatures.\nHigh Temperature Grease. Lubriplate L0312-098. High Temperature Grease. Item #112510878. each. Shipment Options; One Time Shipment. Auto-Replenish. Frequency qty. Add ...\nCONDAT high-temperature greases are formulated to resist high temperatures superior to 130°C. These greases allow a lubricant film to be preserved and provide the apparent viscosity needed for correct operation of your equipment, especially if it is subject to heavy loads generating heat.\nOct 13, 2019 · This high-temperature grease is plastic and rubber safe. The small diameter-sized nozzle gives you control over where you put the grease. It resists moisture and will not wash out.\nThe bearing will squeak once the grease that surrounds it starts to dry. Refer to the dryer's user guide for model-specific information about how to grease the drum's rear bearing. Depending on your model, you might be able to grease the bearing from the backside of the dryer without fully disassembling the drum.\nHigh Temperature Grease - Red . 120lb. Keg. NLGI No. 2. Premium Mystik Lubricant with far more protection than most greases. Outstanding extreme pressure(EP), shock load, rust and corrosion protection . Mystik JT-6 Hi-Temp has proven superior performance in heavy-duty construction, farming, trucking, mining and industrial equipment. Llithium ...\nD-A LUBRICANT CO 12312 D-A ThermoPlex 3 High Temperature Grease #1 - 400 Lb Drum. MPN: 12312, SKU: G7180398. This item ships direct from the manufacturer and has an extended handling time. Please see the Delivery section above for an estimated date of arrival. Product Details\nlubriplate high temp * lubriplate chain cable oil; lubriplate fml-2; mobil mobil cm-w #1 grease; mobil gear oil 629 spartan (ep150) mobil fm 101 (replaces mobil fm 221) mobil polyrex em not rec for gas units; mobil unirex ep-2 (esso unirex rep) mobil vactra #2 oil; mobil xhp221 grease; mobil xhp222 grease; mobil xhp 462 grease; mobilith ...\nMANNOL LC-2 High Temperature Grease 8029 / 8104 / 8094 / 8049 / 8100 / 8108 / 8116.\nHigh Temperature Grease . Petro-Canada PEERLESS Grease adalah grease dengan performance yang premium. Grease untuk multi-aplikasi ini diformulasikan untuk mengurangi biaya operasional dan memberikan perlindungan pada Temperature tinggi (high temperature) yang ekstrim atau kondisi operasi basah (wet operating condition).", "domain": "chemistry", "round": 3} +{"url": "https://journals.iupui.edu/index.php/ias/article/view/7670", "date": "2020-06-06T11:33:54Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-24/segments/1590348513230.90/warc/CC-MAIN-20200606093706-20200606123706-00497.warc.gz", "language_score": 0.6739518642425537, "token_count": 693, "dump": "CC-MAIN-2020-24", "global_id": "webtext-fineweb__CC-MAIN-2020-24__0__138146367", "lang": "en", "text": "John Bain, Vida Farazi and Bruce N. Storhoff. Functionalized Crown Ethers: Benzo Crowns with P(III) Centers.\nMohammad Behforouz, Hamideh Zarrinmayeh and Mark A. Horn. Studies Toward the Total Synthesis of Lavendamycin Methyl Ester, an Antitumor Antibiotic Agent.\nKenneth L. Busch. Applications of Chromotography/Secondary Ion Mass Spectrometry.\nCheryl A. Bye and James P. Rybarczyk. Atomic Spectroscopic and Neutron Activation Analyses of Trace Heavy Metals in Water Supplies Surrounding a Municipal Landfill.\nS.W. Dhawale. Interaction of Some Metals and Tetrathionate Ions.\nVida Farazi, M. Brian Arnold and Bruce N. Storhoff. The Preparation of Functionalized Aza Crown Ethers.\nSusan J. Ganion, Paul L. Bock and Lynn R. Sousa. Potassium Ion Induced Enhancement of Crown Fluorescence by Displacement of a Complexed Quencher.\nMary E. Huss, Jerome I. Kaplan, Stephen R. Wassall and William Stillwell. Electron Spin Resonance of Membranes.\nRichard A. Kjonaas and Douglas Sanquenetti. Reactions of Lithium Triorganozincates with Acid Halides.\nTerry L. Kruger, Timothy T. Curran and Mohammad Behforouz. Electron Impact Mass Spectrometry of ß-Alkylhydrocinnamate Methyl Esters.\nDavid L. McCollum and Paul L. Bock. Validation of a Test to Identify Erythro and Threo Diastereomers of RCHDCHDX Compounds: Variable-temperature NMR Studies of 2-Chloroethanol.\nPang Fai Ma and Jeffrey T. Starkey. A Study of Adenosine Deaminase and Its Conversion Factor in Normal and Pathological Human Serum.\nThomas E. Mabry, C. David Whitesell and Lynn R. Sousa. A Search for a Flashier Crown: Synthesis of a Crown Ether with Potassium Ion Enhanced Fluorescence.\nJohn Sharkitt, Gregory A. Stephenson and James P. Rybarczyk. Three-dimensional Profiling of Matrix-interferences in the ICP.\nKay Stephens, Suzy Pope, Eric R. Johnson and Terry L. Kruger. The Use of Pyridine to Quench the Dansylation of Amino Acids.\nKimberly K. Strouse and Abbas Pezeshk. Magnetic Resonance Investigation of Metal Complexes of Antidiabetic Drugs.\nStephen C. Swinney and Abbas Pezeshk. Spectroscopic Studies of Spin-labeled Tetracycline Metal Complexes.\nAtilla Tuncay and Robert M. Moriarty. Reactions of Phenyl (ß-N-benzenesulfonyl indolyl) Iodonium Chloride with Soft Anions.\nWilliam E. White and Eugene S. Wagner. The Mechanism of L-Ascorbic Acid Entrapment in Human Erythrocytes.", "domain": "chemistry", "round": 3} +{"url": "https://www.mdpi.com/2072-6651/11/7/402", "date": "2019-07-19T04:01:06Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-30/segments/1563195525974.74/warc/CC-MAIN-20190719032721-20190719054721-00067.warc.gz", "language_score": 0.87385493516922, "token_count": 580, "dump": "CC-MAIN-2019-30", "global_id": "webtext-fineweb__CC-MAIN-2019-30__0__97714967", "lang": "en", "text": "Toxic Flatworm Egg Plates Serve as a Possible Source of Tetrodotoxin for Pufferfish\nAbstractThe pufferfish Takifugu niphobles (at present Takifugu alboplumbeus) possesses highly concentrated tetrodotoxin (TTX), an extremely potent neurotoxin that provides effective protection from predators, at least at the larval stages. However, the source of the toxin has remained unclear. Recently, DNA from the toxic flatworm Planocera multitentaculata was detected in the intestinal contents of juveniles and young of the pufferfish, suggesting that the flatworm contributes to its toxification at various stages of its life. In this study, we describe the behavior of the pufferfish in the intertidal zone that appears to contribute to its toxification before and during its spawning period: pufferfish were found to aggregate and ingest flatworm egg plates by scraping them off the surface of rocks. DNA analysis based on 28S rRNA and cytochrome c oxidase subunit I (COI) genes identified the egg plates as those of P. multitentaculata. Liquid chromatography with tandem mass spectrometry analysis revealed that the egg plates contain highly concentrated TTX. The feeding behavior of the pufferfish on the flatworm egg plates was also observed in the aquarium. These results suggest that pufferfish feed on the flatworm egg plate, which enables them to acquire toxicity themselves while providing their offspring with the protective shield of TTX. View Full-Text\n- Supplementary File 1:\nZIP-Document (ZIP, 22814 KB)\nShare & Cite This Article\nOkabe, T.; Oyama, H.; Kashitani, M.; Ishimaru, Y.; Suo, R.; Sugita, H.; Itoi, S. Toxic Flatworm Egg Plates Serve as a Possible Source of Tetrodotoxin for Pufferfish. Toxins 2019, 11, 402.\nOkabe T, Oyama H, Kashitani M, Ishimaru Y, Suo R, Sugita H, Itoi S. Toxic Flatworm Egg Plates Serve as a Possible Source of Tetrodotoxin for Pufferfish. Toxins. 2019; 11(7):402.Chicago/Turabian Style\nOkabe, Taiki; Oyama, Hikaru; Kashitani, Maho; Ishimaru, Yuta; Suo, Rei; Sugita, Haruo; Itoi, Shiro. 2019. \"Toxic Flatworm Egg Plates Serve as a Possible Source of Tetrodotoxin for Pufferfish.\" Toxins 11, no. 7: 402.\nNote that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.", "domain": "chemistry", "round": 3} +{"url": "http://www.labome.org/expert/india/d/d/patrick-d-silva-1955214.html", "date": "2020-04-02T22:41:17Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-16/segments/1585370508367.57/warc/CC-MAIN-20200402204908-20200402234908-00344.warc.gz", "language_score": 0.7822088599205017, "token_count": 649, "dump": "CC-MAIN-2020-16", "global_id": "webtext-fineweb__CC-MAIN-2020-16__0__158894764", "lang": "en", "text": "Patrick D Silva\nBhowmick D, Srivastava S, D Silva P, Mugesh G. Highly Efficient Glutathione Peroxidase and Peroxiredoxin Mimetics Protect Mammalian Cells against Oxidative Damage. Angew Chem Int Ed Engl. 2015;54:8449-53 pubmed publisher\n..The compounds reported in this paper have the potential to be used as therapeutic agents for disorders mediated by reactive oxygen species. ..\nSamaddar M, Goswami A, Purushotham J, Hegde P, D Silva P. Role of the loop L4,5 in allosteric regulation in mtHsp70s: in vivo significance of domain communication and its implications in protein translocation. Mol Biol Cell. 2014;25:2129-42 pubmed publisher\nSaha P, Srivastava S, Kumar S K P, Sinha D, D Silva P. Mapping Key Residues of ISD11 Critical for NFS1-ISD11 Subcomplex Stability: IMPLICATIONS IN THE DEVELOPMENT OF MITOCHONDRIAL DISORDER, COXPD19. J Biol Chem. 2015;290:25876-90 pubmed publisher\n..Furthermore, the R68L ISD11 mutant displayed accumulation of mitochondrial iron and reactive oxygen species, leading to mitochondrial dysfunction, which correlates with the phenotype observed in COXPD19 patients. ..\nBankapalli K, Saladi S, Awadia S, Goswami A, Samaddar M, D Silva P. Robust glyoxalase activity of Hsp31, a ThiJ/DJ-1/PfpI family member protein, is critical for oxidative stress resistance in Saccharomyces cerevisiae. J Biol Chem. 2015;290:26491-507 pubmed publisher\nSinha D, Srivastava S, D Silva P. Functional Diversity of Human Mitochondrial J-proteins Is Independent of Their Association with the Inner Membrane Presequence Translocase. J Biol Chem. 2016;291:17345-59 pubmed publisher\n..Our analysis indicates that the differential cellular phenotype displayed by human mitochondrial J-proteins is independent of their activity and association with Magmas at the translocation channel. ..\nMatta S, Pareek G, Bankapalli K, Oblesha A, D Silva P. Role of Tim17 Transmembrane Regions in Regulating the Architecture of Presequence Translocase and Mitochondrial DNA Stability. Mol Cell Biol. 2017;37: pubmed publisher\n..We conclude that the integrity of Tim17 transmembrane regions is critical for mitochondrial function and protein turnover. ..\nSaha P, Vishwanathan V, Bankapalli K, D Silva P. Iron-Sulfur Protein Assembly in Human Cells. Rev Physiol Biochem Pharmacol. 2018;174:25-65 pubmed publisher\n..The current review highlights recent developments and understanding in the domain of Fe-S cluster assembly biology in higher eukaryotes, particularly in human cells. ..", "domain": "chemistry", "round": 3} +{"url": "https://gardenzoo.org/how-do-you-treat-yellow-leaves-on-azaleas/", "date": "2023-12-03T18:31:56Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100508.42/warc/CC-MAIN-20231203161435-20231203191435-00624.warc.gz", "language_score": 0.9531409740447998, "token_count": 294, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__227598860", "lang": "en", "text": "Last Updated on March 23, 2022 by Sam\nIt is important to remember that a plant’s leaves will turn yellow during the autumn. This process can be accelerated by too much sun exposure, however there are other factors as well such as too little oxygen in the soil, air pollution and nutrient deficiencies like iron.\nThe “azalea leaves turning yellow and red” is a symptom of the plant being too dry. The best way to treat this issue is to water the plant more often, or use a spray bottle with water.\nHow do you fix yellow leaves on azaleas?\nA: There are a few ways to fix yellow leaves on azaleas. You can spray them with a solution of water and hydrogen peroxide, you can soak the leaves in a bucket of vinegar for about 10 minutes, or you can use a mixture of bleach and water.\nThe “azalea leaves turning yellow and brown” is a question that has been asked many times before. The answer to the question is, “Azaleas are not fussy plants.” They will tolerate most conditions and can even be planted in partial shade.\nWatch This Video:\n- azalea leaves turning yellow with black spots\n- iron fertilizer for azaleas\n- azalea leaves turning yellow in summer\n- azalea leaves turning yellow and falling off\n- azalea leaves turning yellow in winter", "domain": "chemistry", "round": 3} +{"url": "https://www.usbattery.com/take-cold-temperature-hydrometer-readings-optimum-battery-performance/", "date": "2023-03-23T08:20:43Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-14/segments/1679296945030.59/warc/CC-MAIN-20230323065609-20230323095609-00671.warc.gz", "language_score": 0.9168508648872375, "token_count": 511, "dump": "CC-MAIN-2023-14", "global_id": "webtext-fineweb__CC-MAIN-2023-14__0__146056242", "lang": "en", "text": "How To Take Cold Temperature Hydrometer Readings For Optimum Battery Performance\nDon’t be alarmed if your golf car fleet operates differently as the winter season sets in. Charge and discharge performance of lead-acid batteries is temperature sensitive, so colder weather can result in lower runtimes. Colder weather can also prevent batteries from getting a full charge, so it’s important to take periodic specific gravity readings. When taking specific gravity measurements, be sure to compensate for the temperature of the battery electrolyte in order to get an accurate reading.\nLead-Acid Battery Temperature Correction Factor\nSpecific gravity readings are referenced against a standard temperature of the electrolyte (not the ambient temperature) of 80-degrees F or 27-degrees C. As a rule of thumb, subtract four points (.004) from your hydrometer reading for every 10-degrees below 80 °F. In Celsius, subtract four points (.004) for every 5.6-degrees below 27°C.\nAs an example; if the temperature of the electrolyte is 50 °F and your battery specific gravity reading is 1.200, you must subtract .012 from your reading. In this case .004 for every 10-degrees equals .012. Subtract this from 1.200 and your corrected specific gravity reading is 1.188. In this reading, the battery cell is less than 50 percent charged and should be recharged before being put into service. If your corrected specific gravity readings are low, simply charge the batteries until the readings are above 1.265 or above your battery manufacturer’s specification.\nTemperature also affects discharge rates. A cold battery will self-discharge slower than a warm battery, but will also exhibit lower capacity. Lower temperature increases the resistance in the battery and causes a reduction in battery capacity. A general rule of thumb to find out the overall capacity of your fleet’s batteries is to figure that for every 15-20 degrees below 80 F, the battery loses 10 percent of its capacity.\nIf your golf car fleet goes into storage during the winter months, make sure that all of the batteries in the fleet are fully charged. This will prevent the electrolyte from freezing and prevent premature battery failure. While in storage, batteries should be boosted every 60 days in colder months and every 30 days in warmer months.\nFor more information on golf car batteries, run-time ratings, and maintenance tips to keep golf car batteries running longer, visit www.usbattery.com.", "domain": "chemistry", "round": 3} +{"url": "https://rd.springer.com/article/10.1007%2Fs00343-019-9125-6", "date": "2019-12-11T18:01:07Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-51/segments/1575540531974.7/warc/CC-MAIN-20191211160056-20191211184056-00228.warc.gz", "language_score": 0.8317119479179382, "token_count": 457, "dump": "CC-MAIN-2019-51", "global_id": "webtext-fineweb__CC-MAIN-2019-51__0__111426185", "lang": "en", "text": "Removal of phenol by Isochrysis galbana in seawater under varying temperature and light intensity\n- 8 Downloads\nPhenol is a common industrial chemical produced and transported worldwide largely. Therefore, accidental spillage of phenol in the ocean causes an increasing concern. Microalgae are promising to remove phenol from marine waters. However, temperature and light intensity are two main factors that markedly influence biodegradation in marine environments. In this study, a marine golden alga Isochrysis galbana is selected to research the removal of phenol under different temperatures (10–30°C) and light intensities (0–240 µmol/(m2·s)). The results show that the most suitable temperature and light intensity for phenol removal are 20°C and 180 µmol/(m2·s), respectively, and 100 mg/L of phenol can be completely removed by microalga in 24 h at these conditions. I. galbana can also remove phenol under dark and low-temperature conditions. The removal of phenol by I. galbana at diverse temperatures and light intensities conform to first-order kinetics, and the process under dark conditions conform to zero-order kinetics. Thus, I. galbana can be used in the in-situ bioremediation of polluted seawater by phenol.\nKeywordphenol Isochrysis galbana temperature light intensity biodegradation\nUnable to display preview. Download preview PDF.\n- Calabrese E J, Kenyon E M. 1991. Air Toxics and Risk Assessment. Lewis Publishers, Chelsea.Google Scholar\n- HELCOM. 2002. Response to Accidents at Sea Involving Spills of Hazardous Substances and Loss of Packaged Dangerous Goods. Baltic Marine Environment Protection Commission, Helsinki, Finland.Google Scholar\n- Song C F, Wei Y L, Qiu Y T, Qi Y, Li Y, Kitamura Y. 2019. Biodegradability and mechanism of florfenicol via Chlorella sp. UTEX1602 and L38: experimental study. Bioresour. Technol., 272: 529–534.Google Scholar", "domain": "chemistry", "round": 3} +{"url": "http://www.fertilitynjblog.com/antioxidant-reverses-bpa-induced-fertility-damage/", "date": "2020-09-18T16:27:43Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-40/segments/1600400188049.8/warc/CC-MAIN-20200918155203-20200918185203-00142.warc.gz", "language_score": 0.9456594586372375, "token_count": 367, "dump": "CC-MAIN-2020-40", "global_id": "webtext-fineweb__CC-MAIN-2020-40__0__232016829", "lang": "en", "text": "From plastics to pesticides, it seems like every week delivers fresh news about the dangers of endocrine disruptors — chemicals in the environment that alter the body’s hormones and can lead to reproductive, developmental, neurologic and immune problems and cancer. Industry regulation and individual consumer choice can reduce exposure to such chemicals, but there are few options to counteract damage that has already occurred.\nNow new research conducted in worms suggests a path toward changing that. A naturally occurring antioxidant known as Coenzyme Q10, or CoQ10, reversed most of the reproductive harms caused by exposure to the plasticizer BPA (bisphenol A) in Caenorhabditis elegans worms, according to a study led by the lab of Monica Colaiácovo, professor of genetics in the Blavatnik Institute at Harvard Medical School.\nThe findings, published in Genetics, provide the first evidence that at least some BPA-induced fertility damage can be undone.\nNevertheless, humans are not big worms, and people should not rush out and start taking CoQ10 as an anti-BPA agent without consulting a doctor, the study authors said. For one thing, the researchers used “very pure,” quality controlled CoQ10, while store-bought supplements vary in CoQ10 content and do not always contain the amounts stated on labels, previous analyses have found.\nFor the authors, though, the findings offer a glimmer of hope amid a flood of concerning findings. “When we uncover evidence of toxicity from yet another chemical, often there is a feeling of ‘Here we go again,'” said Colaiácovo. “But it’s important to see what we can learn from it. I want us to figure out solutions.”", "domain": "chemistry", "round": 3} +{"url": "https://www.hindawi.com/journals/jnt/2013/634726/ref/", "date": "2017-02-25T12:17:40Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-09/segments/1487501171758.35/warc/CC-MAIN-20170219104611-00611-ip-10-171-10-108.ec2.internal.warc.gz", "language_score": 0.7360580563545227, "token_count": 1707, "dump": "CC-MAIN-2017-09", "global_id": "webtext-fineweb__CC-MAIN-2017-09__0__152418578", "lang": "en", "text": "- About this Journal ·\n- Abstracting and Indexing ·\n- Aims and Scope ·\n- Annual Issues ·\n- Article Processing Charges ·\n- Articles in Press ·\n- Author Guidelines ·\n- Bibliographic Information ·\n- Citations to this Journal ·\n- Contact Information ·\n- Editorial Board ·\n- Editorial Workflow ·\n- Free eTOC Alerts ·\n- Publication Ethics ·\n- Reviewers Acknowledgment ·\n- Submit a Manuscript ·\n- Subscription Information ·\n- Table of Contents\nJournal of Nanotechnology\nVolume 2013 (2013), Article ID 634726, 6 pages\nOptimizing the Processing Conditions for the Reinforcement of Epoxy Resin by Multiwalled Carbon Nanotubes\nDepartment of Mechanical Engineering, Indian Institute of Technology Guwahati, Guwahati 781039, India\nReceived 31 May 2013; Accepted 6 July 2013\nAcademic Editor: Guifu Zou\nCopyright © 2013 S. Arun et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.\n- F. H. Gojny, M. H. G. Wichmann, B. Fiedler, and K. Schulte, “Influence of different carbon nanotubes on the mechanical properties of epoxy matrix composites—a comparative study,” Composites Science and Technology, vol. 65, no. 15-16, pp. 2300–2313, 2005.\n- M.-F. Yu, B. S. Files, S. Arepalli, and R. S. Ruoff, “Tensile loading of ropes of single wall carbon nanotubes and their mechanical properties,” Physical Review Letters, vol. 84, no. 24, pp. 5552–5555, 2000.\n- M. Kim, Y.-B. Park, O. I. Okoli, and C. Zhang, “Processing, characterization, and modeling of carbon nanotube-reinforced multiscale composites,” Composites Science and Technology, vol. 69, no. 3-4, pp. 335–342, 2009.\n- O. Starkova, S. T. Buschhorn, E. Mannov, K. Schulte, and A. Aniskevich, “Creep and recovery of epoxy/MWCNT nanocomposites,” Composites A, vol. 43, pp. 1212–1218, 2012.\n- H. Mahfuz, S. Zainuddin, M. R. Parker, T. Al-Saadi, V. K. Rangari, and S. Jeelani, “Reinforcement of SC-15 epoxy with CNT/CNF under high magnetic field: an investigation of mechanical and thermal response,” Journal of Materials Science, vol. 44, no. 4, pp. 1113–1120, 2009.\n- L. He and S. C. Tjong, “Carbon nanotube/epoxy resin composite: correlation between state of nanotube dispersion and Zener tunneling parameters,” Synthetic Metals, vol. 162, pp. 2277–2281, 2012.\n- P.-C. Ma, S.-Y. Mo, B.-Z. Tang, and J.-K. Kim, “Dispersion, interfacial interaction and re-agglomeration of functionalized carbon nanotubes in epoxy composites,” Carbon, vol. 48, no. 6, pp. 1824–1834, 2010.\n- N. A. Buang, F. Fadil, Z. A. Majid, and S. Shahir, “Characteristic of mild acid functionalized multiwalled carbon nanotubes towards high dispersion with low structural defects,” Digest Journal of Nanomaterials and Biostructures, vol. 7, no. 1, pp. 33–39, 2012.\n- M. Theodore, M. Hosur, J. Thomas, and S. Jeelani, “Influence of functionalization on properties of MWCNT-epoxy nanocomposites,” Materials Science and Engineering A, vol. 528, no. 3, pp. 1192–1200, 2011.\n- N. Yu, Z. H. Zhang, and S. Y. He, “Fracture toughness and fatigue life of MWCNT/epoxy composites,” Materials Science and Engineering A, vol. 494, no. 1-2, pp. 380–384, 2008.\n- M. M. Rahman, S. Zainuddin, M. V. Hosur et al., “Improvements in mechanical and thermo-mechanical properties of e-glass/epoxy composites using amino functionalized MWCNTs,” Composite Structures, vol. 94, pp. 2397–2406, 2012.\n- W. Cui, F. Du, J. Zhao et al., “Improving thermal conductivity while retaining high electrical resistivity of epoxy composites by incorporating silica-coated multi-walled carbon nanotubes,” Carbon, vol. 49, no. 2, pp. 495–500, 2011.\n- S. K. Pillai and S. S. Ray, “Epoxy-based carbon nanotubes reinforced composites in advances,” in Nanocomposites—Synthesis, Characterization and Industrial Applications, B. Reddy, Ed., pp. 727–792, 2011.\n- J. G. Park, Q. Cheng, J. Lu et al., “Thermal conductivity of MWCNT/epoxy composites: the effects of length, alignment and functionalization,” Carbon, vol. 50, no. 6, pp. 2083–2090, 2012.\n- K. Esumi, M. Ishigami, A. Nakajima, K. Sawada, and H. Honda, “Chemical treatment of carbon nanotubes,” Carbon, vol. 34, no. 2, pp. 279–281, 1996.\n- M. A. M. Motchelaho, H. Xiong, M. Moyo, L. L. Jewell, and N. J. Coville, “Effect of acid treatment on the surface of multiwalled carbon nanotubes prepared from Fe-Co supported on CaCO3: correlation with Fischer-Tropsch catalyst activity,” Journal of Molecular Catalysis A: Chemical, vol. 335, no. 1-2, pp. 189–198, 2011.\n- ASTM D 695-10., “Standard Test Method for Compressive Properties of Rigid Plastics,” 2010.\n- F. H. Gojny and K. Schulte, “Functionalisation effect on the thermo-mechanical behaviour of multi-wall carbon nanotube/epoxy-composites,” Composites Science and Technology, vol. 64, no. 15, pp. 2303–2308, 2004.\n- L. Guadagno, L. Vertuccio, A. Sorrentino et al., “Mechanical and barrier properties of epoxy resin filled with multi-walled carbon nanotubes,” Carbon, vol. 47, no. 10, pp. 2419–2430, 2009.\n- G. Venkata Ramana, B. Padya, R. Naresh Kumar, K. P. V. Prabhakar, and P. K. Jain, “Mechanical properties of multi-walled carbon nanotubes reinforced polymer nanocomposites,” Indian Journal of Engineering and Materials Sciences, vol. 17, no. 5, pp. 331–337, 2010.", "domain": "chemistry", "round": 3} +{"url": "https://link.springer.com/article/10.1007%2FBF00288610", "date": "2017-05-30T13:26:46Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-22/segments/1495463615105.83/warc/CC-MAIN-20170530124450-20170530144450-00130.warc.gz", "language_score": 0.8731897473335266, "token_count": 264, "dump": "CC-MAIN-2017-22", "global_id": "webtext-fineweb__CC-MAIN-2017-22__0__114072500", "lang": "en", "text": "Identification and characterization of regulatory elements in the phosphoenolpyruvate carboxykinase gene PCK1 of Saccharomyces cerevisiae\n- Cite this article as:\n- Proft, M. & Grzesitza, D. Molec. Gen. Genet. (1995) 246: 367. doi:10.1007/BF00288610\n- 111 Downloads\nPhosphoenolpyruvate carboxykinase is a key enzyme in gluconeogenesis. The expression of the PCK1 gene in Saccharomyces cerevisiae is strictly regulated and dependent on the carbon source provided. Two upstream activation sites (UAS1PCK1 and UAS2PCK1) and one upstream repression site (URSPCK1) were localized by detailed deletion analysis. The efficacy of these three promoter elements when separated from each other was confirmed by investigations using heterologous promoter test plasmids. Activation mediated by UAS1PCK1 or UAS2PCK1 did not occur in the presence of glucose, indicating that these elements are essential for glucose derepression. The repressing effect caused by URSPCK1 was much stronger in glucose-grown cells than in ethanol-grown cells.", "domain": "chemistry", "round": 3} +{"url": "http://www.antikoerper-online.de/signaling-of-hepatocyte-growth-factor-receptor-pathway-111/dock1-elisa-kit-3107/", "date": "2018-01-24T03:48:18Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-05/segments/1516084893300.96/warc/CC-MAIN-20180124030651-20180124050651-00517.warc.gz", "language_score": 0.7017925977706909, "token_count": 1207, "dump": "CC-MAIN-2018-05", "global_id": "webtext-fineweb__CC-MAIN-2018-05__0__9633311", "lang": "en", "text": "Use your antibodies-online credentials, if available.\nKeine Produkte auf Ihrer Vergleichsliste.\nIhr Warenkorb ist leer.\nAlle Spezies anzeigen\nWeitere Synonyme anzeigen\nSelect your species\nHuman DOCK1 ELISA Kit für Sandwich ELISA - ABIN813713\nPan, Li, Duan, Yuan, Fan, Fan, Xiaokaiti, Yang, Wang, Li: Enoxaparin Sensitizes Human Non-Small-Cell Lung Carcinomas to Gefitinib by Inhibiting DOCK1 Expression, Vimentin Phosphorylation, and Akt Activation. in Molecular pharmacology 2015\nA novel signaling cascade is identified in which ELMO1 (zeige ELMO1 ELISA Kits)/DOCK180 regulates vasculature formation in zebrafish.\nThe fusion of embryonic fast-twitch myoblasts requires the activities of Dock1 and the closely related Dock5 protein.\nData suggest that GPR124 (zeige GPR124 ELISA Kits) promotes cell adhesion via interaction with Elmo1 (zeige ELMO1 ELISA Kits)-Dock180 and intersectin 1 (zeige ITSN1 ELISA Kits)/2; this constitutes a previously unrecognized heteromeric complex that is putatively involved in GPR124 (zeige GPR124 ELISA Kits)-dependent adhesive/angiogenic responses in vascular endothelial cells. (GPR124 (zeige GPR124 ELISA Kits) = G-protein coupled receptor 124 (zeige GPR124 ELISA Kits); Elmo1 (zeige ELMO1 ELISA Kits) = ELMO domain-containing protein 1 (zeige ELMOD1 ELISA Kits); Dock180 = dedicator of cytokinesis protein 1 180 kDa)\nstimulation of the DOCK180 pathway represents an alternative mechanism of PTP1B (zeige PTPN1 ELISA Kits) inhibitor-stimulated endothelial cell motility, which does not require concomitant VEGFR2 (zeige KDR ELISA Kits) activation as a prerequisite.\nThus, Elmo1 (zeige ELMO1 ELISA Kits) and Dock180 facilitate blood vessel formation by stabilization of the endothelium during angiogenesis.\nHigh DOCK180 expression is associated with serous ovarian cancer.\nour findings describe a novel mechanism by which EGFRvIII drives glioma tumorigenesis and invasion through protein kinase A-dependent phosphorylation of Dock180\nfindings indicate that a chemokine-controlled pathway, consisting of Galphai2, ELMO1/Dock180, Rac1 and Rac2, regulates the actin cytoskeleton during breast cancer metastasis\nDock180 could act as a pro-survival molecule in H9C2 cardiomyocytes via activation of its downstream pro-survival signaling molecule, AKT (zeige AKT1 ELISA Kits).\nSolved is the solution structure of DOCK180 SH3 domain (zeige ITSN1 ELISA Kits), which shares similar target binding features with the SH3 domain (zeige ITSN1 ELISA Kits) of DOCK2 (zeige DOCK2 ELISA Kits).\nDOCK1-Rac (zeige AKT1 ELISA Kits) signaling as an HER2 (zeige ERBB2 ELISA Kits) effector pathway essential for HER2 (zeige ERBB2 ELISA Kits)-mediated breast cancer progression to metastasis.\nPhosphorylation of Dock180(Y1811) enhanced its association with CrkII (zeige CRK ELISA Kits) & p130(Cas (zeige BCAR1 ELISA Kits)). Dock180 associated with PDGFRalpha to promote cell migration. Phosphorylated Dock180(Y1811) contributes to activation of Rac1 in human cancers with PDGFRA (zeige PDGFRA ELISA Kits) amplification.\nInactivation of Dock1 in mammary gland epithelial cells and activation of Stat3 (zeige STAT3 ELISA Kits) coincide with a delay in the initiation of mammary gland involution.\nDock1 and Dock5 are not the important exchange factors regulating Rac (zeige AKT1 ELISA Kits) activity during the establishment and maintenance of the glomerular barrier\nThe phospholipase D (zeige PLD ELISA Kits)-PA axis selectively controls dorsal ruffle formation by regulating DOCK1 localization.\nThe data demonstrate the ability of the SH3 domain (zeige ITSN1 ELISA Kits) of DOCK180 to interact with ELMO1 (zeige ELMO1 ELISA Kits), regardless of the presence of the polyproline-containing C-terminal end.\nDock1 has an essential role in embryonic development.\nResults indicate that the combination of DOCK2 (zeige DOCK2 ELISA Kits) and DOCK180 plays a significant but not essential role in prevascular fetal thymus colonization.\nThis gene product binds to the SH3 domain of CRK protein. It may regulate cell surface extension and may have a role in the cell surface extension of an engulfing cell around a dying cell during apoptosis.\ndedicator of cytokinesis protein 1\n, dedicator of cytokinesis 1\n, dedicator of cytokinesis protein 1-like\n, dedicator of cytokinesis protein 11\n, dedicator of cytokinesis 11\n, Dedicator of cytokinesis protein 11\n, dedicator of cytokinesis protein 11-like\n, 180 kDa protein downstream of CRK\n, DOwnstream of CrK\n, dedicator of cyto-kinesis 1", "domain": "chemistry", "round": 3} +{"url": "http://www.genetex.com/PPP4C-antibody-C-term-GTX88412.html", "date": "2017-05-01T04:29:28Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-17/segments/1492917127681.50/warc/CC-MAIN-20170423031207-00350-ip-10-145-167-34.ec2.internal.warc.gz", "language_score": 0.8187485933303833, "token_count": 422, "dump": "CC-MAIN-2017-17", "global_id": "webtext-fineweb__CC-MAIN-2017-17__0__147539795", "lang": "en", "text": "|Full Name||protein phosphatase 4, catalytic subunit|\n|Product Description||Goat polyclonal antibody to PPP4C|\n|Background||Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA DSB repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase. |\n|Synonyms||Protein phosphatase 4, catalytic subunit, PPX, PPP4C, PP4, PPH3, Protein phosphatase4, catalytic subunit, protein phosphatase4 (formerly X), catalytic subunit, protein phosphatase 4 (formerly X), catalytic subunit, PP4C, PPP4|\n|Specificity||This antibody is specific for PPP4C.|\n|Species Reactivity||Human, Rat|\n|Predicted Cross Reactivity species Predicted cross-reactivity:|\nPredicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.\nPlease note that we are only able to guarantee products to work in applications and species in which they have been tested.\n|Rat, Dog, Rabbit|", "domain": "chemistry", "round": 3} +{"url": "https://saemobilus.sae.org/content/910614/", "date": "2024-04-13T16:10:13Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712296816820.63/warc/CC-MAIN-20240413144933-20240413174933-00194.warc.gz", "language_score": 0.7841333150863647, "token_count": 684, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__140369160", "lang": "en", "text": "This content is not included in your SAE MOBILUS subscription, or you are not logged in.\nHow to Achieve Optimum Physical Properties in the Metal Catalyst\nISSN: 0148-7191, e-ISSN: 2688-3627\nPublished February 01, 1991 by SAE International in United States\nAnnotation ability available\nTraditionally exhaust catalysts have been dimensioned and adjusted to suit vehicles on the basis of the characteristics and parameters of the ceramic catalyst. The metal catalyst differs, however, so much from the ceramic one that the dimensioning principles of the ceramic catalyst are not altogether appropriate for it. The metal substrate gives the catalyst designer a great deal of latitude in dimensioning, so that the optimum function-durability-price relationship can be achieved. In the metal catalyst the cell density can easily be changed. The geometric surface area, pressure drop and conversion efficiency will all change at the same time. This paper examines the effect of cell densities and catalyst volumes on the functioning of the catalyst. The catalyst performance depends strongly on the temperature. The effect of thermal insulation on a metal catalyst is also examined.\n|Advanced Platinum-Rhodium Exhaust Catalysts - An Economic Alternative To Palladium-Rhodium\n|Some Fundamental Characteristics of Automotive Catalyst Supports\n|Exhaust Heat Containment System\nCitationLylykangas, R. and Lappi, P., \"How to Achieve Optimum Physical Properties in the Metal Catalyst,\" SAE Technical Paper 910614, 1991, https://doi.org/10.4271/910614.\n- Development of Improved Metal-Supported Catalyst Nishizawa Kimiyoshi et al. SAE Paper 890188\n- Mechanical Strength of a Metallic Catalytic Converter Made of Precoated Foil Määttänen Mauri Lylykangas Reijo SAE Paper 900505\n- Metal Supported Automotive Catalysts for Use in Europe Hawker P.N. et al. SAE Paper 880317\n- The Development and Application of a Metal Supported Catalyst for Porsche's 911 Carrera 4 Pelters Stephan et al. SAE Paper 890488\n- New High Performance Gas Flow Equalizing Metal Supports for Automotive Exhaust Gas Catalysts Nonnenmann Manfred SAE Paper 900270\n- Resistive Materials Applied to Quick Light-off Catalysts Hellman K.H. et al. SAE Paper 890799\n- The Behaviour of Metal Supported Catalysts in Subzero Conditions Aitta Eero et al. SAE Paper 890023\n- Novel Autocatalyst Concepts and Strategies for the Future with Emphasis on Metal Supports Öser Polat SAE Paper 880319\n- Comparison of Metal Foil and Ceramic Monolith Automotive Catalyti c Converters Vaneman Gerald L. 2nd International Congress on Catalysis and Automotive Pollution Control Brussels 10th-13th Sept. 1990\n- Impact of Catalyst Support Design Parameters on FTP emissions Socha L. S. Jr. et al. SAE Paper 892041", "domain": "chemistry", "round": 3} +{"url": "https://ebiohippo.com/products/bha11300309", "date": "2019-08-18T04:45:15Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-35/segments/1566027313617.6/warc/CC-MAIN-20190818042813-20190818064813-00138.warc.gz", "language_score": 0.8030001521110535, "token_count": 574, "dump": "CC-MAIN-2019-35", "global_id": "webtext-fineweb__CC-MAIN-2019-35__0__238993846", "lang": "en", "text": "ebiohippo is a top distributor of the best and most reliable ELISA and Assay kits. We can provide a wide range of kits from well-known suppliers and brands with authentic and validated data. We provide antibodies to help you quickly identify and quantify proteins, and evaluate other necessary data for various applications in life sciences.\nAnti-GABBR1 Antibody BHA11300309\nAlternative: Gamma-aminobutyric acid type B receptor subunit 1|GABA-B receptor 1|GABA-B-R1|GABA-BR1|GABABR1|Gb1|GABBR1|GPRC3A|GABB-R1\nSpecies: Homo Sapiens (Human)\nDelivery: Free shipping. Usually ships in 7 to 10 business days\nCategories: Primary Antibodies|Polyclonal Antibodies\nChromosome Location: 6p22.1\nImmunogen: Synthetic peptide, corresponding to amino acids 870-913 of Human GABAB R1.\nDescription: The GABAB R receptor is a heterodimer that consists of two multi-pass membrane proteins, designated GABAB R1 and GABAB R2, both of which belong to the G protein-coupled receptor family and are highly expressed in brain tissue. Together, GABAB R1 and GABAB R2 play a crucial role in the fine-tuning of inhibitory synaptic transmissions and are implicated in slow wave sleep, muscle relaxation, hippocampal long-term potentiation and antinociception events. Both GABAB R1 and GABAB R2 are regulated by G proteins that have a variety of functions, including activation of potassium channels, inhibition of adenylyl cyclase (A cyclase) activity and modulation of inositol phospholipid hydrolysis.\nTARGETWeight: 110 kDa\nPROPERTYStorage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\nPurity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).\nDesc: Product: 1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.Specificity: GABAB R1 (I902) polyclonal antibody detects endogenous levels of GABA-B Receptor protein.\nDescription: Immunohistochemistry (IHC) analyzes of GABAB R1 (I902) pAb in paraffin-embedded human breast carcinoma tissue at 1:50.", "domain": "chemistry", "round": 3} +{"url": "https://fr.slideserve.com/garfield-jonathon/6987185", "date": "2023-05-29T11:07:42Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-23/segments/1685224644855.6/warc/CC-MAIN-20230529105815-20230529135815-00103.warc.gz", "language_score": 0.7819210886955261, "token_count": 580, "dump": "CC-MAIN-2023-23", "global_id": "webtext-fineweb__CC-MAIN-2023-23__0__19100669", "lang": "en", "text": "بسم الله الرحمن الرحيم UMM AL-QURQ UNIVERSITY Faculty of Medicine Dep. Of BIOCHEMISTRY INTRODUCTION\nWhat is Biochemistry?: • The study of life at the molecular level . • Biochemistry is a Research Discipline Applicable to the Real World. Biochemistry: From Atoms to Molecules to Cells : • Biochemical studies lead to a more fundamental understanding of life & impacts the treatment of disease & solves environmental problems.\nMedicine/Clinical/Nutrition: • diagnose and monitor disease. • design drugs (new antibiotics, chemotherapy agents). • Protein and metabolic diseases (diabetes mellitus, hypertension, sickle cell anemia, endocrine diseases, etc…).\nAgriculture: • new herbicides and pesticides. • transgenic crops.\nIndustry (Biotechnology, Genomics, Proteomics, Pharmaceutical): • Synthesis of new drugs. • Detoxification. • Other industrial processes.\nThree Areas of Study: Conformational: • structure and 3D arrangements of biomolecules. Metabolism: • energy production and utilization. Informational: • language for communication inside and between cells. DNARNAProteinCellular Processes.\nCode of practice: • Mouth pipetting should be prohibited. • Eating, Drinking, Smoking and applying cosmetics should not be permitted in the laboratory work area. • The laboratory should be kept neat, clean and free of materials not pertinent to the work. • Work surface should be decontaminated at least once a day, and after any spill of potentially dangerous material. • Cleaning the glassware after use.\nHAZZARDOUS PROPERTIES OF LABORATORY CHEMICALS: • Incompatible Chemicals: Many chemicals commonly found in the laboratory undergo dangerous reactions if allowed to come into contact during storage or else where. • Other chemicals are known to have reported acute and chronic effects.\nCHECKOUT PROCEDURE: • Clean your portion of the desktop, scrubbing it with soap and rinsing it if necessary. • Clean through your desk and the sink at the end. • Clean and dry all apparatus. • . Leave no marks or labels on glassware other than unavoidable scratches and etches. • Oil the screws on the lamp and iron ring. • Empty the desk completely and line the drawer with a paper towel. • Arrange the apparatus.\nABDULLATIF TAHA ABDULLAMSc. BIOCHEMISTRY سبحانك لا علم لنا إلا ما علمتنا * إنك أنت العليم الحكيم 0", "domain": "chemistry", "round": 3} +{"url": "https://scholars.duke.edu/display/pub644931", "date": "2022-10-03T04:33:10Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-40/segments/1664030337398.52/warc/CC-MAIN-20221003035124-20221003065124-00742.warc.gz", "language_score": 0.9145953059196472, "token_count": 499, "dump": "CC-MAIN-2022-40", "global_id": "webtext-fineweb__CC-MAIN-2022-40__0__276942326", "lang": "en", "text": "Effects of modulation of glycerol kinase expression on lipid and carbohydrate metabolism in human muscle cells.\nGlycerol is taken up by human muscle in vivo and incorporated into lipids, but little is known about regulation of glycerol metabolism in this tissue. In this study, we have analyzed the role of glycerol kinase (GlK) in the regulation of glycerol metabolism in primary cultured human muscle cells. Isolated human muscle cells exhibited lower GlK activity than fresh muscle explants, but the activity in cultured cells was increased by exposure to insulin. [U-(14)C]Glycerol was incorporated into cellular phospholipids and triacylglycerides (TAGs), but little or no increase in TAG content or lactate release was observed in response to changes in the medium glycerol concentration. Adenovirus-mediated delivery of the Escherichia coli GlK gene (AdCMV-GlK) into muscle cells caused a 30-fold increase in GlK activity, which was associated with a marked rise in the labeling of phospholipid or TAG from [U-(14)C]glycerol compared with controls. Moreover, GlK overexpression caused [U-(14)C]glycerol to be incorporated into glycogen, which was dependent on the activation of glycogen synthase. Co-incubation of AdCMV-GlK-treated muscle cells with glycerol and oleate resulted in a large accumulation of TAG and an increase in lactate production. We conclude that GlK is the limiting step in muscle cell glycerol metabolism. Glycerol 3-phosphate is readily used for TAG synthesis but can also be diverted to form glycolytic intermediates that are in turn converted to glycogen or lactate. Given the high levels of glycerol in muscle interstitial fluid, these finding suggest that changes in GlK activity in muscle can exert important influences on fuel deposition in this tissue.\nMontell, E; Lerín, C; Newgard, CB; Gómez-Foix, AM\nVolume / Issue\nStart / End Page\nInternational Standard Serial Number (ISSN)\nDigital Object Identifier (DOI)", "domain": "chemistry", "round": 3} +{"url": "https://allaboutshipping.co.uk/2015/05/27/evoqua-water-technologies-receives-us-patent-for-seacure-ballast-water-management-system/", "date": "2021-03-08T03:05:01Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-10/segments/1614178381803.98/warc/CC-MAIN-20210308021603-20210308051603-00341.warc.gz", "language_score": 0.92377108335495, "token_count": 603, "dump": "CC-MAIN-2021-10", "global_id": "webtext-fineweb__CC-MAIN-2021-10__0__163486942", "lang": "en", "text": "· U.S. Patent No. 8, 968, 575 B2 “METHOD AND SYSTEM FOR TREATING BALLAST WATER”\n· Second U.S. patent awarded for IMO Type Approved and USCG AMS accepted ballast water treatment system\nWARRENDALE, PA, USA … Evoqua Water Technologies has been awarded a second United States patent on its technical solution for treating ballast water. This latest patent was granted by the United States Patent and Trademark Office on the 3rd of March, 2015.\nThe patent describes a technical solution for treating ballast water under a variety of ambient water qualities. The quality of ambient water can vary widely from port to port where the ship is taking on its ballast. The unique features of Evoqua’s system include the use of oxidation reduction potential (“ORP”) devices to control certain SeaCURE™* system operations.\nThe patented SeaCURE system takes into account variations in demand and delivers biocide at the dose necessary for successful biofouling control, while minimising unwanted side effects such as formation of disinfection by-products and corrosion. The ORP system developed by Evoqua employs low-maintenance, easy to handle probes that measure the oxidising potential of the water in both the sea chest and the ballast tank as, input for controlling the addition or concentration of biocide that is ultimately introduced into the shipboard cooling water system. Controlling the SeaCure system in this way saves energy and reduces operating costs.\nThe SeaCURE Ballast Water Management System prevents the displacement of organisms in a two-step approach. After a first step of fine filtration to remove large organisms and mineral sediments, the remaining organisms are eliminated by the addition of an active substance – sodium hypochlorite. This is produced in-situ via electrolysis from seawater eliminating the need to purchase biocides and store or replenish them onboard. Electrolysis is carried out using Evoqua’s Chloropac®* self-cleaning concentric tubular electrodes (CTE) which sit at the heart of the SeaCURE system. Chloropac systems are renowned in the industry and have been used for marine growth protection of shipboard cooling systems since the 1970s.\n“We are proud of this innovation combining a novel approach with decades of proven technology that will help ship owners to meet IMO and USCG regulations reliably” says Ian Stentiford, Global Vice President for Electrocatalytic Products within Evoqua. ‘The SeaCURE system is currently being extensively tested in the United States Laboratories for US Coast Guard type approval to be able to give our customers further peace-of-mind’.\nThe SeaCURE system also utilises a patented* process that protects ballast filters against growth of marine organisms that can clog the filters.", "domain": "chemistry", "round": 3} +{"url": "https://elearning.eflm.eu/course/view.php?id=34&lang=ru", "date": "2021-12-05T13:41:22Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-49/segments/1637964363189.92/warc/CC-MAIN-20211205130619-20211205160619-00517.warc.gz", "language_score": 0.9435568451881409, "token_count": 405, "dump": "CC-MAIN-2021-49", "global_id": "webtext-fineweb__CC-MAIN-2021-49__0__161071029", "lang": "en", "text": "Speaker: Michael Cornes (UK)\nModerator: João Tiago Guimarães (PT)\nRecorded on: 15th May 2018\nNational and international (WHO, CLSI) guidelines recommended that order of draw of blood during phlebotomy should be blood culture/sterile tubes, then plain tubes/gel tubes, then tubes containing additives. This prevents contamination of sample tubes with additives from previous tubes for example sodium citrate or more commonly potassium EDTA (K3EDTA).\nThese recommendations are based on a case report by and a follow up study by Calam and Cooper in 1982 which reported that incorrect order of draw caused hyperkalaemia and hypocalcaemia. By measuring EDTA, it has been demonstrated that reverse order of draw of blood samples using closed loop venesection systems does not cause EDTA contamination. It is difficult to reconcile the directly conflicting results of these studies but it may be that reversed order of draw using poor technique and/or difficult venepuncture may result in sample tube cross-contamination.\nIt has been shown that contamination is still relatively common and may be difficult to identify. As this is not due to reversed order of draw of blood samples in a closed loop system other mechanisms must be in operation. Here I will present the evidence for and against the need to follow an order of draw.\nAbout the speaker\nI am Dr Mike Cornes an Consultant Clinical Scientist at Worcestershire Acute Hospitals NHS Trust in the UK. I am also the chair of the UK Preanalytics working group. I have been the Young Member of the EFLM Preanalytical working group since 2013. I have interests in the preanalytical phase, specifically around phlebotomy, sample contamination and data collection, IT and Mass Spectrometry. I have published several papers in this area.", "domain": "chemistry", "round": 3} +{"url": "http://www.ingentaconnect.com/content/wef/wefproc/2012/00002012/00000010/art00021", "date": "2017-12-18T10:13:51Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-51/segments/1512948612570.86/warc/CC-MAIN-20171218083356-20171218105356-00140.warc.gz", "language_score": 0.8873043060302734, "token_count": 478, "dump": "CC-MAIN-2017-51", "global_id": "webtext-fineweb__CC-MAIN-2017-51__0__149764716", "lang": "en", "text": "Wastewater Treatment using Activated Carbon Nanofiber Anode Microbial Fuel Cells (MFCs)\nMicrobial fuel cell (MFC) technology is a pioneering bio-electrochemical system (BES) exploiting anaerobic bacteria to harvest useful energy from various organic substrates in wastewater. Commercial anode's of significance for MFC applications are carbon based material (carbon cloth (CC), brush or graphite rod), which have been shown to have high internal resistance and low power generation capacities. The study investigated a new anode material, activated carbon nanofiber (ACNF) to enhance biofilm formation and electron transfer in the anode chamber of MFCs. The distinct features of ACNF are high porosity and exceptionally large surface areas, resulting in better biofilm growth, electron transfer, power generation and contaminant removal, which have a great potential for MFC systems to treat wastewaters. Batchscale tests showed that MFCs with ACNF and granular activated carbon (GAC) as anodes achieved power densities of 3.50±0.46W/m3 and 3.09±0.33W/m3 respectively, while SCMFCs with CC had a lower power density of 1.10±0.21W/m3. In addition, the MFCs with ACNF achieved higher contaminant removal efficiency (85±4%) than those of GAC (75±5%), and CC (70±3%). This work has revealed several distinct advantages of biofilm growth, electron transfer, power generation and organics removal for ACNF, with potential future applications of MFC systems to treat waste waters.\nNo Reference information available - sign in for access.\nNo Citation information available - sign in for access.\nNo Supplementary Data.\nNo Article Media\nDocument Type: Research Article\nPublication date: 2012-01-01\nWEF Members: Sign in (right panel) with your IngentaConnect user name and password to receive complimentary access. Access begins 12 months after the conference or event\n- Subscribe to this Title\n- Membership Information\n- About WEF Proceedings\n- WEFTEC Conference Information\n- Learn about the many other WEF member benefits and join today\n- Ingenta Connect is not responsible for the content or availability of external websites", "domain": "chemistry", "round": 3} +{"url": "http://www.epitomics.com/products/data_sheet/4603-1", "date": "2013-05-21T03:12:56Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2013-20/segments/1368699675907/warc/CC-MAIN-20130516102115-00038-ip-10-60-113-184.ec2.internal.warc.gz", "language_score": 0.8098680973052979, "token_count": 346, "dump": "CC-MAIN-2013-20", "global_id": "webtext-fineweb__CC-MAIN-2013-20__0__88033059", "lang": "en", "text": "Fra-1 DyLight® 488 Rabbit Monoclonal\nRabbit Monoclonal Antibody | Product Data Sheet\n|Quantity: 100UL||Lot #: Please refer to vial|\n|Clone ID: EP4711||Molecular Wt.: 40 kDa|\n|Species Cross-reactivity n/dHumann/dMousen/dRat||UniProt ID: P15407|\nBackground: The Fos family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. Fra-1, known as Fos-related Antigen 1 or FOSL1, is a leucine zipper protein that can dimerize with JUN family proteins, thereby forming the transcription factor complex AP-1. As such, Fra-1 has been implicated as regulators of cell proliferation, differentiation, and transformation (1).\nSpecificity: A synthetic peptide corresponding to residues in human Fra-1 was used as an immunogen.\nStorage Condition and Buffer: Store at 2-8° C. PBS (pH 7.2), 0.02% sodium azide, 0.05% BSA. Protect from light. Stable for 6 months from date of receipt.\n1. Entrez Gene: gene-centered information at NCBI. Nucleic Acids Res. 2005 Jan 1;33:D54-8.\nFig 1. Immunofluorescent staining of A431 cells using anti-Fra-1 antibody conjugated with Dylight 488 (green, Cat# 4603-1) and Dapi (blue).", "domain": "chemistry", "round": 3} +{"url": "https://www.ecosystemtech.com.ph/what-are-surfactants/", "date": "2023-01-31T10:45:59Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-06/segments/1674764499857.57/warc/CC-MAIN-20230131091122-20230131121122-00398.warc.gz", "language_score": 0.9582674503326416, "token_count": 272, "dump": "CC-MAIN-2023-06", "global_id": "webtext-fineweb__CC-MAIN-2023-06__0__44524732", "lang": "en", "text": "June 23, 2020\nDo you know what constitutes wastewater? It’s a combination of food scraps, chemicals, soaps, oils, stormwater, human waste, and the like. Such chemicals can include surfactants, which you can find in detergents and cleaning products because they make dirt or oil easier to wash away. Here’s what you need to know about surfactants and how they affect us.\nNow that you have an idea of what these chemicals are, you can better appreciate scientists and wastewater treatment plants. While surfactants are indeed helpful in keeping dishes and clothes clean, it has to be disposed of properly through treatment. Only through further study can we come up with better surfactants that will have less of an impact on the environment.\nJanuary 26, 2023\nDistillation and reverse osmosis–these are just some of the water filtration methods you can use for your home!Read more\nFebruary 24, 2020\nYou might enjoy safe drinking water from your tap, but are you aware of today’s global water issues? According to the United Nations, communities around […]Read more\nNovember 26, 2021\nAmidst the global pandemic, sanitary engineers around the world have the responsibility to address and resolve the growing challenges in public health and the environment.Read more", "domain": "chemistry", "round": 3} +{"url": "http://www.abcam.cn/tom1l2-antibody-ab121748.html", "date": "2018-04-26T18:03:48Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-17/segments/1524125948426.82/warc/CC-MAIN-20180426164149-20180426184149-00496.warc.gz", "language_score": 0.6621620059013367, "token_count": 509, "dump": "CC-MAIN-2018-17", "global_id": "webtext-fineweb__CC-MAIN-2018-17__0__123084025", "lang": "en", "text": "antigen sequence, corresponding to amino acids 288-384 (LLHVNDDLNN VFLRYERFER YRSGRSVQNA SNGVLNEVTE DNLIDLGPGS PAVVSPMVGN TAPPSSLSSQ LAGLDLGTES VSGTLSSLQQ CNPRDGF) of Human TOM1L2.\n- Human heart muscle tissue.\nShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.\nPreservative: 0.02% Sodium azide\nConstituents: 59% PBS, 40% Glycerol\nConcentration information loading...\nImmunogen affinity purified\nOur Abpromise guarantee covers the use of\nin the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\n||1/50 - 1/200. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.\nProbable role in protein transport. May regulate growth factor-induced mitogenic signaling.\nUbiquitously expressed with higher expression in heart and skeletal muscle.\nBelongs to the TOM1 family.\nContains 1 GAT domain.\nContains 1 VHS domain.\nThe GAT domain mediates interaction with TOLLIP.\nInformation by UniProt\n- FLJ32746 antibody\n- Srebf1 antibody\n- Target of Myb-like protein 2 antibody\nImmunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TOM1L2 antibody (ab121748)\nab121748 at 1/75 dilution staining TOM1L2 in Paraffin-emebedded Human heart muscle tissue by Immunohistochemistry.\nImmunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-TOM1L2 antibody(ab121748)\nImmunohistochemical staining of Human heart muscle shows moderate cytoplasmic positivity in myocytes using ab121748\nhas not yet been referenced specifically in any publications.\nPlease note: All products are \"FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE\"", "domain": "chemistry", "round": 3} +{"url": "https://pubs.geoscienceworld.org/books/book/1438/chapter/107174105/Staining", "date": "2018-07-19T23:23:37Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-30/segments/1531676591332.73/warc/CC-MAIN-20180719222958-20180720002958-00278.warc.gz", "language_score": 0.9088970422744751, "token_count": 301, "dump": "CC-MAIN-2018-30", "global_id": "webtext-fineweb__CC-MAIN-2018-30__0__81565265", "lang": "en", "text": "Staining techniques are among the fastest, simplest, and cheapest methods for getting reliable data on composition of detrital grains or cements in sandstones. Stains for calcite, organic matter, K-feldspar, and plagioclase are among the most useful stains.\nThe top photo shows a sandstone (Pennsylvanian Tensleep of Wyoming; 0.10 mm) which has been stained for calcite using Alizarin Red S. Calcite and dolomite are both present as cements but only the calcite has taken the red stain. Note imperfections in staining of calcite near thin edges of crystals and where bubbles were present. Because of the similarity in optical properties of calcite and dolomite, such staining is essential for accurate identification of these minerals.\nThe lower photo shows a K-feldspar (sanidine) from a Tertiary intrusive in Nevada (0.28 mm). This originally colorless grain was stained for potassium using a sodium cobaltinitrite solution. The lack of twinning and cleavage in this grain make it difficult to differentiate from quartz without time-consuming optical study. Staining, however, provides a rapid and reliable alternative for routine petrographic studies.\nDirections for stain preparation are given in the references by Bailey and Stevens (1960), Laniz, et al (1964), Dickson (1966), Friedman (1971), and Whitlatch and Johnson (1974).", "domain": "chemistry", "round": 3} +{"url": "http://martinica.in/11277_iron-ore-pellets-fines-generation-stacking.html", "date": "2018-09-24T01:23:46Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-39/segments/1537267160085.77/warc/CC-MAIN-20180924011731-20180924032131-00488.warc.gz", "language_score": 0.9133307933807373, "token_count": 469, "dump": "CC-MAIN-2018-39", "global_id": "webtext-fineweb__CC-MAIN-2018-39__0__174058848", "lang": "en", "text": "Jan 1, 2012 . . direct reduction plants in converting iron ore (in the form of pellets or lump .. This method results in significant fines generation, as much as 8-1o percent. . and third is likely tobe stacking of ore for storage after unloading.\nthe form of pellets or lump ore) to iron, specifically, regarding the quantity of ore .. results in significant fines generation, as much as 8-1o percent. These fines . sel, and third is likely to be stacking of ore for storage after unload- ing. In each of.\nKey Words: Coated iron ore pellets, Pelletisation, Calcined lime coating . RDI implies high degree of fines generation and unfavorable gas distribution in the blast .. Either during the initial stages of Blast Furnace operation (i.e., upper stack.\nKeywords:Mining, Low grade iorn ore, Pellet plant, Beneficiation, EIA. 1. . calibrated lump and fines are required which corresponds to iron ore mining of approx. 400 MMT of . This is normally done by the process of blasting, which results in generation of .. PCDDF. Separate ESP for Stack for PM and flue gas treatment.\nIron Ore fines are Iron Ore that have been crushed to under 10mm.Iron Ore pellets are Iron Ore fines that have been concentrated andbonded together to form.\nto Improve the Consistency in Cold Crushing Strength of Iron Ore Pellets. Aditya Sarda1, Naik . Less fines generation at the time of reducing. 13. Easy handling.\nThe Midrex gas generation system consists of a CO; reformer using their own catalyst. The feed . to remove the oxygen from iron ore pellets and lump ore. .. shaft-type furnace with a vertical stack superimposed over a crucible-like hearth. Iron . The Technored process consists of pelletizing of the iron ore fines with cement.\n5.6 Annual Averages of process stack gas emissions at Tata Steel . In sintering iron ore fines, other iron bearing wastes and coke dust are blended .. of each zone with the forward movement of the pellet throughout the entire .. Production of sized iron ore lump in the mechanized mines results in generation of appreciable.", "domain": "chemistry", "round": 3} +{"url": "https://www.cephamls.com/gng7-antibody-hrp-conjugated/", "date": "2022-08-08T10:47:11Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882570793.14/warc/CC-MAIN-20220808092125-20220808122125-00641.warc.gz", "language_score": 0.756662130355835, "token_count": 386, "dump": "CC-MAIN-2022-33", "global_id": "webtext-fineweb__CC-MAIN-2022-33__0__183224963", "lang": "en", "text": "Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7, GNG7, GNGT7\nRecombinant human Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 protein (2-65AA)\nELISA;Not yet tested in other applications.\nBackground / Function\nGuanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Plays a role in the regulation of adenylyl cyclase signaling in certain regions of the brain. Plays a role in the formation or stabilzation of a G protein heterotrimer (G(olf) subunit alpha-beta-gamma-7) that is required for adenylyl cyclase activity in the striatum.\nPreservative: 0.03% Proclin 300\nConstituents: 50% Glycerol, 0.01M PBS, PH 7.4\nShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.\n>95%,Protein G purified", "domain": "chemistry", "round": 3} +{"url": "https://researchrepository.wvu.edu/etd/4658/", "date": "2021-04-11T13:47:35Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-17/segments/1618038062492.5/warc/CC-MAIN-20210411115126-20210411145126-00614.warc.gz", "language_score": 0.9120385050773621, "token_count": 441, "dump": "CC-MAIN-2021-17", "global_id": "webtext-fineweb__CC-MAIN-2021-17__0__44397994", "lang": "en", "text": "Date of Graduation\nEberly College of Arts and Sciences\nWith the advent of quantitative reverse-transcription real-time polymerase chain reaction, RNA has increasingly become an invaluable tool to forensic science investigations. For instance, previous studies have shown that the age of a biological stain could be estimated using differential decay rates of different RNA segments, providing a temporal link between the suspect and the crime. By co-isolating RNA and DNA from the same sample, both a genetic profile and various other analyses can be conducted. RNA samples are frequently treated with DNase prior to analysis to rid samples of contaminating DNA. Although all manufacturers of DNase claim no loss of RNA-derived signal, our results indicate that only those based upon heat inactivation of the DNase showed acceptable levels of signal loss. Loss of cDNA is not permissible for studies where levels of starting RNAs are crucial in obtaining accurate results. Ideally, primers and probes for estimating relative RNA levels will be designed to span exon-exon boundaries such that DNA contamination cannot provide a false signal. Unfortunately such primer and probe locations are not always possible. We also investigated the feasibility of using RNA degradation as a means of determining the approximate ex vivo age of semen samples. Our results indicate that, unlike bloodstains and other biological specimens, RNA contained within dried semen samples do not degrade in a predictable fashion after the first few days following deposition. After approximately 1--1.5 years, differential degradation was observed in dried semen stains therefore the use of this technique for exclusionary purposes may be possible. Our results also indicate that primers and probes designed to detect small segments of semen specific RNAs can be used to identify dried semen samples at least 1.5--2 years of ex vivo age. Liquid samples did show differential decay rates shortly after deposition. In conclusion, RNA will likely become a fundamental tool in the near future for forensic investigations but it must be kept in mind that the manufactures claims should be validated before all examinations.\nSmith, Tiffany Lynn, \"Investigating the potential of RNA to be used in forensic casework analysis\" (2010). Graduate Theses, Dissertations, and Problem Reports. 4658.", "domain": "chemistry", "round": 3} +{"url": "https://www.ammacement.in/building-materials/what-should-be-the-initial-setting-time-of-cement.html", "date": "2024-02-24T14:18:04Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707947474533.12/warc/CC-MAIN-20240224112548-20240224142548-00373.warc.gz", "language_score": 0.9219842553138733, "token_count": 1851, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__101070683", "lang": "en", "text": "Conclusion – Initial and final setting time of cement are very important properties of cement, which are responsible for the quality of concrete and mortar. Hence it is advisable to check the initial setting time and final setting time of cement before you use it for the construction work.\n- 0.1 What is initial setting time for cement?\n- 0.2 What is initial & final setting time of cement?\n- 1 What is normal setting of cement?\n- 2 What is the setting time of Ultratech cement?\n- 3 What is initial setting time of cement Mcq?\n- 4 Why initial setting time is important?\n- 5 What is a good cement ratio?\n- 6 What is the initial setting time of OPC?\n- 7 What is the initial setting time of cement Nptel?\n- 8 Which type of cement has a final setting time of 30 minutes?\n- 9 What causes initial setting of cement?\nWhat is initial setting time for cement?\nThe setting of cement starts within 5 minutes after addition of water and it becomes hard like stone in less than 30 minutes or so.\nWhat is initial & final setting time of cement?\nInitial and Final Setting Time of OPC Cement? For OPC, the Minimum setting initial setting is 30 min and the maximum final setting time is 600 min.\nWhy is the initial setting of cement 30 minutes?\nIn this time cement can be molded in any desired shape without losing its strength. This is the time at which the hardening of the cement starts and the only time available for mixing the paste and placing it in position. if this time less then 30 min then can’t molded in any shape in many situations.\nWhat is normal setting of cement?\nFinal setting time of Cement:- – The time at which cement completely loses its plasticity and became hard is a final setting time of cement. Or The time taken by cement to gain its entire strength is a Final setting time of cement. For Ordinary Portland Cement, The Final Setting Time is 600 minutes (10hrs).\nWhat is the setting time of Ultratech cement?\nCure the concrete for a minimum of 10 days in normal weather conditions,. During hot weather (greater than 40°C), cure the concrete for a minimum of 14 days.\nWhat is initial setting time of cement Mcq?\n8. What is the initial setting time of cement? Explanation: As per IS code 4031-part 5, the initial setting time of cement is minimum of 30 minutes.\nWhy initial setting time is important?\nFAQs – What is initial setting time of cement? The initial setting time of concrete is the time when cement paste starts hardening after adding water. It is the time period between the addition of water to cement till the time at 1 mm square section needle fails to penetrate the cement paste, placed in the Vicat’s mold 5mm to 7mm from the bottom of the mold.\nWhat is final setting time of cement? Final setting time is that time period between the time water is added to cement and the time at which 1 mm needle makes an impression on the paste in the mould but 5 mm attachment does not make any impression. What is the need for determining initial and final setting time of cement? Initial setting time is the time when the paste starts losing its plasticity.\nThe test is important for transportation, placing and compaction of cement concrete. Initial setting time duration is also required to delay the process of hydration or hardening. Final setting time is the time when the paste completely loses its plasticity.It is the time taken for the cement paste or cement concrete to harden sufficiently and attain the shape of the mould in which it is cast.\nWhy gypsum is added in cement?\nGypsum is added to control the ‘setting of cement’. If not added, the cement will set immediately after mixing of water leaving no time for concrete placing.\nWhat is a good cement ratio?\nIn terms of the ratio for concrete, it depends on what strength you are trying to achieve, but as a general guide a standard concrete mix would be 1 part cement to 2 parts sand to 4 parts aggregates. For foundations, a mix of 1 part cement to 3 parts sand to 6 parts aggregates can be used.\nWhat is the initial setting time of OPC?\nInitial setting time should not be less than 30 minutes and final setting time should not be greater than 600 minutes as per IS 12269.\nWhich grade cement is used for RCC?\n43 Grade Ordinary Portland Cement (OPC 43) – OPC 43 cement shall conform to IS:8112-1989 and the designed strength of 28 days shall be minimum 43 MPa or 430 kg/sqcm. Even though 43 Grade cements’ early strength is less as compared to that of 53 Grade, with time it will attain the same ultimate strength as that of 53 Grade cement.\n- In the case of 43 Grade cement, the initial setting of cement is slower as compared to 53 Grade cement.\n- In other words, the hydration process and consequently, the release of heat is moderate and therefore, occurrence of micro cracking is much less and can be easily controlled by proper curing of the concrete / masonry work.\nUnless a project requires very high strength cement, the use of 43 Grade OPC is generally recommended in general civil construction work such as residential, commercial and industrial structures. It is used in RCC works, preferably where the grade of concrete is up to M-30.\n- It is also extensively used in the manufacture of pre-cast items such as blocks, pipes, tiles etc., and also in asbestos products such as sheets and pipes.\n- Since OPC 33 has mostly been phased out in the country, OPC 43 is nowadays largely used in plastering, flooring and other non structural applications where OPC 33 was earlier being used.\nThe physical and chemical characteristics of OPC 43 Grade Deccan Cement very comfortably meets BIS requirements. Particularly, the compressive strength of Deccan Cement OPC 43 is significantly higher than the standards specified by BIS.\nWhich cement grade is better 43 or 53?\nOPC 53 sets quicker than OPC 43 and has a quite low initial setting time. It is used in structures where rapid strength gain is required like large load bearing structures like bridges, huge buildings, etc. OPC 43 on the other hand doesn’t set so quickly and has a normal initial and final setting time.\nWhat is the initial setting time of cement Nptel?\nFor an ordinary portland cement, the initial setting time should not be less than 30 minutes while the final setting time should not be more than 600 minutes.\nWhat is the initial setting time of cement 15 minutes 30 hours 1 hour 30 minutes?\nInitial setting time should not be less than 30 minutes and final setting time should not be greater than 600 minutes as per IS 12269.Q.\nWhich type of cement has a final setting time of 30 minutes?\n|Kamran Iqbal said: (Nov 15, 2019)\n|OPC:(Ordinary Portland cement) Initial setting time = 30 min. Final setting time = 10 hours. LPC:(Lime pozzolana cement) Initial setting time= 120 min (2 hours). Final setting time = 6 hours. High alumina cement: Initial setting time= 3.5 hours. Final setting time= 5 hours.\nWhy setting time of cement is important?\nImportance of Initial And Final Setting Time – After mixing cement with water, placing the cement paste in a position requires time. Initial setting time plays an essential role in the strength of cement or concrete. In the case of ordinary Portland cement, the cement paste or concrete must be placed before crossing the initial setting time.i.e., 30 minutes and should not be disturbed until it meets the Final setting time, i.e., 600 minutes,\n- The cement should not be set too fast and not be too slow. If it set rapidly, it doesn’t offer sufficient time for transportation and placing of the concrete. While if it is set too late, it can slow down the work and might be postponed due to less strength at the desired time.\n- The setting of cement should not be compared with hardening. It is a mechanical strength gained after a specific time interval to resist the penetration of a special attachment dropped into it.\n- Initial setting time is essential to transport, placing and compaction of concrete.\n- Initial setting time is necessary to delay the hydration process and hardening.\n- Final setting time helps to remove shuttering or formwork safely.\n- Cement completed its chemical reaction with water till the final setting time.\nWhat causes initial setting of cement?\nTricalcium Aluminate (C3A) – It is responsible for the initial setting time, high heat of hydration and has greater tendency to volume changing causing cracking.", "domain": "chemistry", "round": 3} +{"url": "https://www.hala-tec.fr/news/product-of-the-month-september-2023/", "date": "2024-02-27T17:30:52Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707947474676.79/warc/CC-MAIN-20240227153053-20240227183053-00224.warc.gz", "language_score": 0.8634930849075317, "token_count": 336, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__8687713", "lang": "en", "text": "📢 Discover the advantages of TGL-U-NS, the solution for excellent thermal connections over long distances. 🌡️💡\nTGL-U-NS is an electrically insulating, thermally conductive, high viscosity, dispensable and silicone-free form-in-place #gapfiller that provides optimal thermal management for numerous applications. It is ideal for bridging height differences between electronic components and for compensating significant tolerances. 👍\nThe gap filler is the ideal solution for heat dissipation in applications in the #automotive industry, #notebooks, #medicaltechnology, #industrialcomputers and many others.\nThe exceptional thermal conductivity of TGL-U-NS is due to its unique formulation using ceramic powder. This innovative compound also eliminates the need for additional curing processes, saving you time and resources. 💡\nWhat makes TGL-U-NS special is its meterable, viscoplastic nature, which provides optimum thermal contact without the need to apply pressure. 😌👌\nBy using TGL-U-NS, you can also minimize the overall resistance of the thermal interface, thereby increasing the reliability and performance of your electronic systems. 🌟\n📲 Visit our website at https://www.hala-tec.com/gap-filler-silikonfrei-en/tgl-u-ns/ to learn more about TGL-U-NS and its potential applications.\nOr reach out to us today to learn more and get started. 💼📞: +49 7021 73141 79", "domain": "chemistry", "round": 3} +{"url": "http://www.actris.it/index.php/en/observationsites-menu-item-eng/os-lecce-menu-subitem-eng", "date": "2023-10-01T05:09:07Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233510781.66/warc/CC-MAIN-20231001041719-20231001071719-00233.warc.gz", "language_score": 0.8467506170272827, "token_count": 861, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__18799813", "lang": "en", "text": "The Lecce observation site consists of the CNR-ISAC Environmental-Climate Observatory of Lecce and the Aerosol&Climate Laboratory of the University of Salento.\nIt is an ‘urban background’ site located about 4 km SW of the urban area of Lecce at about 15 km from the Adriatic Sea and between 30 km and 80 km from the industrial complexes of Brindisi and Taranto (the largest complexes of the Region Puglia).\nThe site is optimal for monitoring natural pollution sources such as Saharan dust transport from North Africa towards Europe, forest fires in North Africa or Southern Italy or volcanic emissions.\nThe contribution of regional scale pollutions due to biomass burning, agricultural wastes, and secondary pollutants production as well as new particle formation and growth events could be efficiently investigated at the observatory.\nMoreover, it represents an integrated system based on observations and models in order to better evaluate the aerosol transport and its impact on the radiative budget of the Earth-Atmosphere system and thus on the climate, in particular over the Mediterranean area.\nTherefore, the Aerosol&Climate laboratory carries out research activity in order to characterize both ground-based and columnar atmospheric components and to study their effects on the climate system by using radiative transfer models and regional climate models.\nThe research activity carried out at the site is linked to several observational networks (GAW-WMO, EARLINET, ACTRIS, AERONET).\nThe site hosts a suite of active and passive remote sensing and ground-based instruments that provide climatologically significant observations of the main aerosol optical and microphysical properties at the surface and along the aerosol column. It represents the largest permanent observation site in the Apulia region.\nInstruments operative at the site:\nMeteorology and radiation\n- T, P, RH, WD, WI\n- shortwave and longwave upwelling and downwelling\n- Pyranometers and pyrgeometres\n- Reynolds stresses and kinetic turbulent energy\n- Sensible heat fluxes\n- Surface Ozone\n- Sulfur Dioxide\n- Carbon Dioxide, Metane, Carbon monoxide\n- Nitrogen oxides (NO and NO2).\n- Particle number size distribution using an Optical Particle Counter (size range: 280 nm - 10µm)\n- Particle number size distribution using a SMPS (size range 10-800 nm)\n- Aerosol daily mass concentrations of PM2.5 and PM10\n- OC and EC for PM2.5 and PM10 offline (about 10 samples per month)\n- Aerosol chemistry (intensive campaings)\n- Scattering and back scattering coefficient (450, 550, 700 nm)\n- Absorption coefficient (630 nm)\n- Integrating nephelometer\n- Equivalent black carbon concentration, derived from absorption coefficient\n- Particle number fluxes (eddy-covariance) and total particle number concentrations (size range 4 nm to 3μm), post-processed offline with 30 mins resolution\n- Differential Optical Absorption Spectroscopy (DOAS)\n- LIDAR UNILE\n- Sun-lunar photometer\n- Integration with measurements from devices on-board satellites as MODIS and CALIPSO\nFor more information please visit:", "domain": "chemistry", "round": 3} +{"url": "https://www.officedirectsupply.com/comet_pgc30314ct_disinfecting_cleaner_w_bleach_32_oz._plastic_309137_prd1.htm", "date": "2022-06-26T07:46:20Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-27/segments/1656103037649.11/warc/CC-MAIN-20220626071255-20220626101255-00097.warc.gz", "language_score": 0.6958889365196228, "token_count": 369, "dump": "CC-MAIN-2022-27", "global_id": "webtext-fineweb__CC-MAIN-2022-27__0__39140781", "lang": "en", "text": "Mfg Number: 30314CT\nHeavy-duty detergents with Chlorinol® bleach power through soap scum, grease and hard-water stains without scrubbing.\nDisinfects and deodorizes toilets and urinals.\nNon-abrasive formula is effective against tough kitchen and bathroom soils.\nBleaches food stains on countertops, tables, and cutting boards.\nHospital use disinfectant effective against Clostridium difficile spores, Staphylococcus aures (Staph), Staphylococcus aures Methycillin resistant (MRSA), Norovirus (Norwalk) and more.\n|Global Product Type||Cleaners & Detergents-Disinfectant/Cleaner|\n|Applicable Material||Ceramics; Enamel; Fiberglass; Glass; Grout; Laminates; Metal; Plastic; Sealed/Engineered Stone; Vinyl|\n|Dirt Types||Bacteria; Fungus; Germs; Grease; Grime; Mildew; Mineral Scale; Organic Matter; Soap Scum; Water-Based Soil|\n|Packing Type||Spray Bottle|\n|Capacity (Volume)||32 oz|\n|Compliance Standards||EPA Registered; LEED Applicable|\n|Pre-Consumer Recycled Content Percent||0%|\n|Post-Consumer Recycled Content Percent||0%|\n|Total Recycled Content Percent||0%|", "domain": "chemistry", "round": 3} +{"url": "http://yunghkio.com/01-2019-102.php", "date": "2019-09-22T09:51:14Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-39/segments/1568514575484.57/warc/CC-MAIN-20190922094320-20190922120320-00165.warc.gz", "language_score": 0.9421368837356567, "token_count": 1412, "dump": "CC-MAIN-2019-39", "global_id": "webtext-fineweb__CC-MAIN-2019-39__0__115040051", "lang": "en", "text": "Radiocarbon dating in geology and archaeology\nForget that would about monitoring rump to get, narrowing the man to pay, and never rushed sex on a first time. Archaeology in and dating Radiocarbon geology. Get Ethiop look to every lesbians in Essex, now implementing chatrooms, forums and even unbound messaging between members. . Within whereabouts emotional and pleasurable personals network aesthetic invalidate social networking site for sex arc of the more.\nThere was a problem providing the content you requested\nBy commandant the behavior of the measurements of outcomes used in exploring is more insulting and consistent. Questioning containers with screw baths are not, but it is still interested to require the future condensed for the best sites of adult dating samples.\nThe result of this is to supply streams, rivers, and lakes with a source of dissolved calcium carbonate ; if freshwater shellfish for example use this to construct their shells, then they are using a source of carbon which is millions of years old. Clearly applying radiometric dating in such a case is pointless. Another source of old carbon is the outgassing from volcanoes: Even participation in the terrestrial carbon cycle does not quite guarantee the date: By and large, however, organisms tend to consume fresh vegetation or fresh meat, so this problem is unlikely to arise in practice.\nComparison with known dates[ edit ] One way we can check the efficacy of radiocarbon dating is to compare the dates it produces with dates known on historical grounds, to ensure that it does indeed give us the right answer. We can also compare radiocarbon dates with dates known on other grounds.\nFor example, we have discussed the use of varves for dating; now since varves incorporate organic material as they ggeology formed, we can check that when we radiocarbon date a varve, we get the same date datiny it as we obtain by counting the varves. Also it is obviously possible to carbon-date one of the growth rings of a tree, and to compare the date produced by radiocarbon dating with the date produced by dendrochronology. Such dates typically agree to within 1 or 2 per cent. Calibrated dating[ edit ] Although the radiocarbon dates agree closely with dendrochronologythey do not agree exactly. It is generally agreed that the dendrochronological dates should be considered the more accurate.\nThe proportion of 14C in the atmosphere is not absolutely constant; for example, it can be reduced by volcanic activity, since the carbon dioxide emitted by volcanoes is richer in 12C than atmospheric carbon dioxide. By comparison the behavior of the genera of trees used in dendrochronology is more reliable and consistent. It is therefore standard procedure to tweak the raw geoloyy dates to bring them in line with dendrochronology, producing what are known as calibrated radiocarbon dates. Some labs, for example, do not date carbonates.\nRadiocarbon dating in geology and archaeology must also geloogy consulted as to the required amount of sample that they ideally like to process as well as their preference with certain samples for carbon dating. Other labs accept waterlogged wood while others prefer them dry at submission. Sample collection Contaminants must not be introduced Radiocarbin the samples during collection and storing. Hydrocarbons, dzting, biocides, polyethylene glycol or polyvinyl acetate PVA must not come in contact with samples for radiocarbon dating.\nOther potential contaminants include paper, cardboard, cotton wool, string and cigarette ash. Sample storage Samples must be stored in packaging materials that will protect them during transport and even during prolonged storage. Labels attached to the packaging materials must not fade or rub off easily. Glass containers can be used when storing radiocarbon dating samples, but they are susceptible to breakage and can be impractical when dealing with large samples. Aluminum containers with screw caps are safe, but it is still best to consult the radiocarbon laboratory for the best containers of carbon dating samples.\nErrors and calibration It is recommended that archaeologists, or any client in general, ask the laboratory if results have systematic or random errors. They should also ask details about the calibration used for conversion of BP years to calendar years. Cost Clarify the costs involved in radiocarbon dating of samples. Some labs charge more for samples that they do not regularly process. Timescale Radiocarbon dating takes time, and laboratories often have waiting lists so this factor must be considered. Sample identification The carbon dating process is destructive, and labs usually advise their clients with regard to sample identification or labelling. Types of contaminant Communication with clients also gives labs an idea of the possible types of contaminants in the excavation site.\nKnowing the type of contaminants also give radiocarbon scientists an idea on the pretreatment methods needed to be done before starting carbon dating. After an organism dies, the radiocarbon decreases through a regular pattern of decay. This is called the half-life of the isotope. Half-lives vary according to the isotope, for example, Uranium has a half-life of million years where as Nitrogen has a half-life of 4.\nIn archaeology and Radiocarbon dating geology\nWhen Libby was first determining radiocarbon dates, he found that before BC daing dates were earlier than calendar dates. He had assumed that amounts of Carbon in the atmosphere had remained constant through time. In fact, levels of Carbon have varied in the atmosphere through time. Therefore, radiocarbon dates need to be calibrated with other dating techniques to ensure accuracy. Plants are not the only organism that can process Carbon from the air. Since plankton is the foundation of the marine food chain, Carbon is spread throughout aquatic life.\nPassionately, the weaker the sample the alien, although new people Radiodarbon smaller cities can sometimes be snapshot more carefully. The blinded elements of the source code com vary in how much lying they store, and in how adorable it traits for the 14 C productive by looking singles to fully mix with them.\nIn recognition of this problem archaeologists have developed regional reservoir correction rates based on ocean bottom topography, water temperature, coastline shape and paired samples of terrestrial and marine objects found together in an archaeological feature such as a hearth. Long tree-ring sequences have been developed throughout the world and can be used to check and calibrate radiocarbon dates. An extensive tree-ring sequence from the present to BC was developed in Arizona using California bristlecone pine Pinus aristatasome of which are years old, making them the oldest living things on earth. Additional sequences have been developed for oak species in Ireland and Germany, ice core samples, and coral reefs from Caribbean islands.\nThese sequences have helped to calibrate radiocarbon dates to calendar years, thus making them more accurate.", "domain": "chemistry", "round": 3} +{"url": "https://christie.openrepository.com/handle/10541/108882", "date": "2020-09-23T07:16:43Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-40/segments/1600400209999.57/warc/CC-MAIN-20200923050545-20200923080545-00153.warc.gz", "language_score": 0.7298738956451416, "token_count": 322, "dump": "CC-MAIN-2020-40", "global_id": "webtext-fineweb__CC-MAIN-2020-40__0__283310425", "lang": "en", "text": "Chemical cross linking subtraction (CCLS): a new method for the generation of subtractive hybridisation probes.\nAffiliationCRC Department of Experimental Haematology, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, UK.\nMetadataShow full item record\nCitationChemical cross linking subtraction (CCLS): a new method for the generation of subtractive hybridisation probes. 1992, 20 (11):2899 Nucleic Acids Res.\nJournalNucleic Acids Research\n- Chemical crosslinking subtraction (CCLS).\n- Authors: Hampson IN, Hampson L\n- Issue date: 1997\n- Rapid aggregation of gold nanoparticles induced by non-cross-linking DNA hybridization.\n- Authors: Sato K, Hosokawa K, Maeda M\n- Issue date: 2003 Jul 9\n- A new strategy for a DNA assay based on a target-triggered isothermal exponential degradation reaction.\n- Authors: Zhao J, Liu T, Fan Q, Li G\n- Issue date: 2011 May 14\n- Oligonucleotide-templated reactions for sensing nucleic acids.\n- Authors: Shibata A, Abe H, Ito Y\n- Issue date: 2012 Feb 29\n- Bioorthogonal labeling of 5-hydroxymethylcytosine in genomic DNA and diazirine-based DNA photo-cross-linking probes.\n- Authors: Song CX, He C\n- Issue date: 2011 Sep 20", "domain": "chemistry", "round": 3} +{"url": "https://proteomecommons.org/polyclonal-antibody-to-interferon-gamma-ifng-paa049hu06/?setCurrencyId=3", "date": "2023-12-08T22:09:10Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100779.51/warc/CC-MAIN-20231208212357-20231209002357-00861.warc.gz", "language_score": 0.7650712132453918, "token_count": 323, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__27837605", "lang": "en", "text": "Polyclonal Antibody to Interferon Gamma (IFNg) | PAA049Hu06\n- Usually Shipped in 5 Working Days\nPolyclonal Antibody to Interferon Gamma (IFNg) | PAA049Hu06 | Cloud-Clone\nDescription: A polyclonal antibody rasied in rabbit against human Interferon Gamma\nPolyclonal Antibody to Interferon Gamma (IFNg) is Available at Gentaur Genprice with the fastest delivery.\nOnline Order Payment is possible or send quotation to email@example.com.\nSpecifications: Antibody type: Polyclonal; Species reactivity: Human; Host: Rabbit; Label: None; Concentration (may vary between Lots): 0.51mg/ml; Tested applications: WB; IHC; ICC; IP.; Uniprot ID of immunogen: P01579; Sequence of immunogen: Gln24~Gln166; Form: Liquid\nAdditional Information: Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.; Purification method: Antigen-specific affinity chromatography followed by Protein A affinity chromatography; Alternative antigen names: IFN-G; IFG; IFI; INFr; IFN, Immune Interferon\nStorage and shipping: Shipped on ice packs. For short term storage keep at +4C. For long term storage keep frozen and -20C.\nNotes: For research use only.", "domain": "chemistry", "round": 3} +{"url": "https://beautyline.com.cy/sun-kids-wet-skin-mist-200ml-spf50", "date": "2021-05-06T21:25:44Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-21/segments/1620243988763.83/warc/CC-MAIN-20210506205251-20210506235251-00256.warc.gz", "language_score": 0.6854854226112366, "token_count": 543, "dump": "CC-MAIN-2021-21", "global_id": "webtext-fineweb__CC-MAIN-2021-21__0__138748697", "lang": "en", "text": "This time-saving, water resistant, anti-sand mist can be applied even onto wet skin, without leaving traces after spreading, and provides ultra broad-spectrum Full Light Technolofy protection against all 4 sun rays (UVB + UVA + VISIBLE LIGHT + INFRARED) to keep kids ideally protected in the sun. High protection products. Airless conditioning means container may seem empty when product still left.\nAvoid direct sun exposure for babies and young children and keep them well covered with light clothes, hat and sun glasses. Shake well before use, until you hear the ball. Apply generously all over the child's body, before sun exposure, in an open area. Spread the product over the skin with your hands after spraying.\nBUTANE, AQUA/WATER/EAU, DIISOPROPYL ADIPATE, OCTOCRYLENE, HOMOSALATE, GLYCERIN, BUTYL METHOXYDIBENZOYLMETHANE, NYLON-12, PEG-30 DIPOLYHYDROXYSTEARATE, ETHYLHEXYL METHOXYCINNAMATE, PHENYLBENZIMIDAZOLE SULFONIC ACID, CYCLOHEXASILOXANE, DIMETHICONE, BIS-ETHYLHEXYLOXYPHENOL METHOXYPHENYL TRIAZINE, ISODODECANE, 1,2-HEXANEDIOL, ASCORBIC ACID, ASCORBYL PALMITATE, BHT, CAPRYLYL GLYCOL, CITRIC ACID, CYCLOPENTASILOXANE, DIMETHYLMETHOXY CHROMANOL, DISODIUM EDTA, ORBIGNYA OLEIFERA SEED OIL, PANTHENOL, PANTOLACTONE, PEG-8, PEG/PPG-18/18 DIMETHICONE, POLY C10-30 ALKYL ACRYLATE, POLYMETHYLSILSESQUIOXANE, SODIUM CHLORIDE, SODIUM HYDROXIDE, SQUALANE, SUCROSE, TAPIOCA STARCH, TOCOPHEROL, TOCOPHERYL ACETATE, TRISILOXANE, UBIQUINONE, XANTHOPHYLL, CHLORPHENESIN, PHENOXYETHANOL, PARFUM/FRAGRANCE", "domain": "chemistry", "round": 3} +{"url": "https://www.birmingham.ac.uk/research/activity/phenome-centre/about/publications.aspx", "date": "2020-08-06T02:17:26Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-34/segments/1596439735990.92/warc/CC-MAIN-20200806001745-20200806031745-00254.warc.gz", "language_score": 0.7101872563362122, "token_count": 3036, "dump": "CC-MAIN-2020-34", "global_id": "webtext-fineweb__CC-MAIN-2020-34__0__112509175", "lang": "en", "text": "Key publications from the lead investigators since 2009\nDunn, WB Erban A, Weber RJM, Creek DJ, Brown M, Breitling R, Hankemeier T, Goodacre R, Neumann S, Kopka J and Viant MR. Mass appeal: metabolite identification in mass spectrometry-focused untargeted metabolomics. Metabolomics, 2013, 9, S44-66.\nDunn WB, Wilson ID, Nicholls AW and Broadhurst D. The importance of experimental design and QC samples in large-scale and MS-driven untargeted metabolomic studies of humans. Bioanalysis. 2012, 4, 2249-64.\nDunn WB, Broadhurst DI, Atherton HJ, Goodacre R and Griffin JL. Systems level studies of mammalian metabolomes: the roles of mass spectrometry and nuclear magnetic resonance spectroscopy. Chem. Soc. Rev. 2011, 40, 387-413.\nTechnology and Method Development\nDavidson RL, Weber RJ, Liu H, Sharma-Oates A, Viant MR. Galaxy-M: a Galaxy workflow for processing and analyzing direct infusion and liquid chromatography mass spectrometry-based metabolomics data. Gigascience, 2016, 5, 10.\nHao J, Liebeke M, Sommer U, Viant MR, Bundy JG, Ebbels TM. Statistical Correlations between NMR Spectroscopy and Direct Infusion FT-ICR Mass Spectrometry Aid Annotation of Unknowns in Metabolomics. Anal Chem. 2016, 88, 2583-9.\nMullard G, Allwood JW, Weber R, Brown M, Begley P, Hollywood KA, Jones M, Unwin RD, Bishop PN, Cooper GJS. and Dunn, WB. . A new strategy for MS/MS data acquisition applying multiple data dependent experiments on Orbitrap mass spectrometers in non-targeted metabolomic applications. Metabolomics, 2015, 11, 1068-80.\nBradbury J. Genta-Jouve G., Allwood JW, Dunn WB, Goodacre R, Knowles JD, He S. and Viant MR. MUSCLE: Automated closed loop multi-objective evolutionary LC-MS/MS method optimisation for targeted analysis. Bioinformatics, 2015, 31, 975-7.\nZhou J, Weber RJM, Allwood JW, Mistrik R, Zhu Z, Ji Z, Chen S, Dunn WB, He S. and Viant MR. HAMMER: Automated operation of Mass Frontier to construct in-silico mass spectral fragmentation libraries. Bioinformatics, 2014, 30, 581-3\nKirwan JA, Broadhurst DI, Davidson RL and Viant MR. Characterising and correcting batch variation in an automated direct infusion mass spectrometry (DIMS) metabolomics workflow. Anal. Bioanal. Chem. 2013, 405, 5147-57.\nKotze HL, Armitage EG, Sharkey KJ, Allwood JW, Dunn WB, Williams KJ and Goodacre R. A novel untargeted metabolomics correlation-based network analysis incorporating human metabolic reconstructions. BMC Systems Biology, 2013, 7, 107.\nWeber RJM, Li E, Bruty J, He S and Viant MR. MaConDa: a publicly accessible Mass spectrometry Contaminants Database. Bioinformatics, 2012, 28, 2856-57.\nVaughan AA, Dunn WB, Allwood JW, Wedge DC, Blackhall FH, Whetton AD, Dive C and Goodacre R. Liquid chromatography-mass spectrometry calibration transfer and metabolomics data fusion. Anal. Chem. 2012, 84, 9848-57.\nLudwig C, Easton JM, Lodi A, Tiziani S, Manzoor S, Southam AD, Byrne JJ, Bishop LM, He S, Arvanitis TN, Günther UL and Viant MR. Birmingham Metabolite Library: A publicly accessible database of 1-D 1H and 2-D 1H J-resolved NMR spectra of authentic metabolite standards (BML-NMR). Metabolomics, 2012, 8, 8-18.\nWedge DC, Allwood JW, Dunn WB, Vaughan AA, Simpson K, Brown M, Priest L, Blackhall FH, Whetton AD, Dive C and Goodacre, R. Is serum or plasma more appropriate for intersubject comparisons in metabolomic studies? An assessment in patients with small-cell lung cancer. Anal. Chem. 2011, 83, 6689-97.\nDunn WB, Broadhurst D, Begley P, Zelena E, Francis-McIntyre S, Anderson N, Brown M, Knowles JD, Halsall A, Haselden JN, Nicholls AW, Wilson ID, Kell DB, Goodacre R. and the Human Serum Metabolome (HUSERMET) Consortium. Procedures for large-scale metabolic profiling of serum and plasma using gas chromatography and liquid chromatography coupled to mass spectrometry. Nature Protocols, 2011, 6, 1060-83.\nBrown M, Wedge DC, Goodacre R, Kell DB, Baker PN, Kenny LC, Mamas MA, Neyses L and Dunn WB Automated workflows for accurate mass-based putative metabolite identification in LC/MS-derived metabolomic datasets. Bioinformatics 2011, 27, 1108-12.\nWeber RJM and Viant MR. MI-Pack: Increased confidence of metabolite identification in mass spectra by integrating accurate masses and metabolic pathways. Chemometrics and Intelligent Laboratory Systems, 2010, 104, 75-82.\nBegley P, Francis-McIntyre S, Dunn WB, Broadhurst DI, Halsall A, Tseng A, Knowles J,, HUSERMET Consortium, Goodacre R and Kell DB. Development and Performance of a Gas Chromatography-Time-of-Flight Mass Spectrometry Analysis for Large-Scale Nontargeted Metabolomic Studies of Human Serum. Analytical Chemistry, 2009, 81, 7038-46.\nZelena E, Dunn WB, Broadhurst D, Francis-McIntyre S, Carroll KM, Begley P, O'Hagan S, Knowles JD, Halsall A, HUSERMET Consortium, Wilson ID and Kell DB. Development of a Robust and Repeatable UPLC-MS Method for the Long-Term Metabolomic Study of Human Serum. Analytical Chemistry, 2009, 81, 1357-64.\nBrown M, Dunn WB, Dobson P, Patel Y, Winder CL, Francis-McIntyre S, Begley P, Carroll K, Broadhurst D, Tseng A, Swainston N, Spasic I, Goodacre R and Kell DB. Mass spectrometry tools and metabolite-specific databases for molecular identification in metabolomics. Analyst, 2009, 134, 1322-32.\nZhang J, Abou-Elwafa Abdallah M, Williams TD, Harrad S, Chipman JK and Viant MR. Gene expression and metabolic responses of HepG2/C3A cells exposed to flame retardants and dust extracts at concentrations relevant to indoor environmental exposures. Chemosphere, 2016, 144, 1996-2003.\nSoutham AD, Khanim FL, Hayden RE, Constantinou JK, Koczula KM, Michell RH, Viant MR, Drayson MT and Bunce CM. Drug Redeployment to Kill Leukemia and Lymphoma Cells by Disrupting SCD1-Mediated Synthesis of Monounsaturated Fatty Acids. Cancer Res., 2015, 75, 2530-40.\nDunn WB, Lin W, Broadhurst D, Begley P, Brown M, Zelena E, Vaughan AA, Halsall A, Harding N, Knowles JD, Francis-McIntyre S, Tseng A, Ellis DI, O’Hagan S, Aarons G, Benjamin B, Chew-Graham S, Moseley C, Potter P, Winder CL, Potts C, Thornton P, McWhirter C, Zubair M, Pan M, Burns A, Cruickshank JK, Jayson GC, Purandare N, Wu FCW, Finn JD, Haselden JN, Nicholls AW, Wilson ID, Goodacre R. and Kell DB. Molecular phenotyping of a UK population: defining the human serum metabolome. Metabolomics, 2015, 11, 9-26.\nDrury NE, Howell NJ, Calvert MJ, Weber RJ, Senanayake EL, Lewis ME, Hyde JA, Green DH, Mascaro JG, Wilson IC, Graham TR, Rooney SJ, Viant MR, Freemantle N, Frenneaux MP and Pagano D. The effect of perhexiline on myocardial protection during coronary artery surgery: a two-centre, randomized, double-blind, placebo-controlled trial. Eur J Cardiothorac Surg., 2015, 47, 464-72.\nDrogan D, Dunn WB, Lin W, Buijsse B, Schulze MB, Langenberg C, Brown M, Floegel A, Dietrich S, Rolandsson O, Wedge DC, Goodacre R, Forouhi NG, Sharp SJ, Spranger J, Wareham NJ and Heiner H. Untargeted metabolic profiling identifies altered serum metabolites of type 2 diabetes mellitus in a prospective, nested case-control study. Clinical Chemistry, 2014,. 61, 487-97.\nAnderson, S.G., Dunn, W.B., Banerjee, M., Brown, M., Broadhurst, D.I., Goodacre, R., Cooper, G.J.S., Kell, D.B. and Cruickshank, J.K. Evidence That Multiple Defects in Lipid Regulation Occur before Hyperglycemia during the Prodrome of Type-2 Diabetes. PloS One, 2014, e103217\nLodi A, Tiziani S, Khanim FL, Günther UL, Viant MR, Morgan GJ, Bunce CM, Drayson MT. Proton NMR-based metabolite analyses of archived serial paired serum and urine samples from myeloma patients at different stages of disease activity identifies acetylcarnitine as a novel marker of active disease. PLoS One. 2013, 8, e56422.\nThiele I, Swainston N, Fleming RMT et al. A community-driven global reconstruction of human metabolism. Nature Biotechnology, 2013, 31, 419-25.\nYoung SP, Kapoor SR, Viant MR, Byrne JJ, Filer A, Buckley CD, Kitas GD and Raza K. The impact of inflammation on metabolomic profiles in patients with arthritis. Arthritis Rheum., 2013, 65, 2015-23.\nDunn WB, Brown M,Worton SA, Davies K, Jones RL, Kell DB and Heazell, AEP. The metabolome of human placental tissue: investigation of first trimester tissue and changes related to preeclampsia in late pregnancy. Metabolomics, 2012, 8, 579-97.\nDunn WB, Summers A. Brown M, Goodacre R, Lambie M, Johnson T, Wilkie M, Davies S, Topley N and Brenchley P. Proof-of-principle study to detect metabolic changes in peritoneal dialysis effluent in patients who develop encapsulating peritoneal sclerosis. Nephrol. Dial. Transplant. 2012, 27, 2502-10.\nUgarte M, Brown M, Hollywood KA, Cooper GJ, Bishop P and Dunn WB. Metabolomic analysis of rat serum in streptozotocin-induced diabetes and after treatment with oral triethylenetetramine (TETA). Genome Med. 2012, 4, 35.\nLodi A, Tiziani S, Khanim FL, Drayson MT, Günther UL, Bunce CM and Viant MR. Hypoxia triggers major metabolic changes in AML cells without altering indomethacin-induced TCA cycle deregulation. ACS Chem. Biol., 2011, 6, 169-75.\nSoydemir F, Kuruvilla S, Brown M, Dunn WB, Day P,, Crocker IP, Baker PN, Sibley CP and Brownbill P. Adapting in vitro dual perfusion of the human placenta to soluble oxygen tensions associated with normal and pre-eclamptic pregnancy. Lab. Invest., 2011, 91, 181-89.\nHorgan RP, Broadhurst DI, Walsh SK, Dunn WB, Brown M, Roberts CT, North RA, McCowan LM, Kell DB, Baker PN and Kenny LC. Metabolic profiling uncovers a phenotypic signature of small for gestational age in early pregnancy. J. Proteome Res. 2011, 10, 3660-73.\nKenny LC, Broadhurst DI, Dunn WB, Brown M, North RA, McCowan L, Roberts C, Cooper GJS, Kell DB. and Baker PN. Robust early pregnancy prediction of later preeclampsia using metabolomic biomarkers. Hypertension, 2010, 56, 741-49.\nHorgan R, Broadhurst DI, Dunn WB, Brown M, Heazell AE, Kell DB, Baker PN and Kenny LC. Changes in the Metabolic Footprint of Placental Villous Explant-Conditioned Medium cultured in different oxygen tensions from placentas of Small for Gestational Age and normal pregnancies. Placenta, 2010, 31, 893-901.\nKhanim FL, Hayden RE, Birtwistle J, Lodi A, Tiziani S, Davies NJ, Ride JP, Viant MR, Gunther UL, Mountford JC, Schrewe H, Green RM, Murray JA, Drayson MT and Bunce CM. Combined bezafibrate and medroxyprogesterone acetate: potential novel therapy for acute myeloid leukaemia. PLoS One. 2009, 4, e8147.", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/tbrg1-antibody-ab203276.html", "date": "2020-10-21T19:04:51Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-45/segments/1603107877420.17/warc/CC-MAIN-20201021180646-20201021210646-00279.warc.gz", "language_score": 0.804425060749054, "token_count": 500, "dump": "CC-MAIN-2020-45", "global_id": "webtext-fineweb__CC-MAIN-2020-45__0__210005485", "lang": "en", "text": "Key features and details\n- Rabbit polyclonal to TBRG1\n- Suitable for: IHC-P\n- Reacts with: Mouse, Rat, Human\n- Isotype: IgG\nProduct nameAnti-TBRG1 antibody\nDescriptionRabbit polyclonal to TBRG1\nTested applicationsSuitable for: IHC-Pmore details\nSpecies reactivityReacts with: Mouse, Rat, Human\nStorage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.\nStorage bufferPreservative: 0.09% Sodium azide\nConstituents: 50% Glycerol, 0.01% BSA\nConcentration information loading...\nPurityProtein A purified\nOur Abpromise guarantee covers the use of ab203276 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\n|IHC-P||1/100 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.\nUse at 1/50 - 1/200 with fluorescent detection methods.\nRelevanceFunction: Acts as a growth inhibitor. Can activate p53/TP53, causes G1 arrest and collaborates with CDKN2A to restrict proliferation, but does not require either protein to inhibit DNA synthesis. Redistributes CDKN2A into the nucleoplasm. Involved in maintaining chromosomal stability. Tissue specificity: Widely expressed at low levels in most tissues, with highest levels in pancreas, lung and liver. Expression is decreased in primary tumors including lung, liver, breast, pancreas and kidney carcinomas, chronic lymphocytic leukemia and diffuse large B-cell lymphoma. Similarity: Belongs to the TBRG1 family. Contains 1 FYR C-terminal domain. Contains 1 FYR N-terminal domain. PTM: Ubiquitinated; mediated by MDM2 and leading to its subsequent proteasomal degradation.\n- NIAM antibody\n- Nuclear interactor of ARF and Mdm2 antibody\n- TB 5 antibody\nab203276 has not yet been referenced specifically in any publications.", "domain": "chemistry", "round": 3} +{"url": "https://whitefog.com/sub_tags/al-ain/", "date": "2023-03-22T16:26:46Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-14/segments/1679296943845.78/warc/CC-MAIN-20230322145537-20230322175537-00715.warc.gz", "language_score": 0.8304796814918518, "token_count": 432, "dump": "CC-MAIN-2023-14", "global_id": "webtext-fineweb__CC-MAIN-2023-14__0__234954966", "lang": "en", "text": "Showing all 26 results\nThermal Fogger – Thermal Fogging Machine SM600Engine: 30 Hp. Pulse-Jet\nTank: 5,7 Lt. (Stainless steel)\nVehicle Mounted Thermal Fogger – Pulse Jet Machine SM700Engine: 112 Hp. Pulse Jet\nTank: 60 Lt. (Stainless steel)\nElectric Portable ULV Cold Fogger Machine Manufacturer – MiniULVEngine: Electrical\nTank: 5 Lt. (Polyethylene)\nFumigation Machine Thermal Fogging – SM900Engine: 57,3 Hp. Pulse Jet\nTank: 100 Lt. (Stainless Steel)\nal ain Thermal Foggers - al ain Cold Foggers\nal ain Thermal Foggers\nal ain Thermal Foggers Most thermal foggers have a spray nozzle, a heating chamber and a tank or reservoir. Inside the tank is a pump that carries the chemical to the heating chamber to be converted into mist. Most thermal foggers have a spray nozzle, a heating chamber and a tank or reservoir. Inside the tank is a pump that carries the chemical to the heating chamber to be converted into mist. It normally takes the pre-heating process for 2 to 5 minutes. Once it is ready, you can simply unlock the trigger if any, or just pull the trigger. It should produce a misting fox reaching up to 15 feet.\nal ain Cold Foggers\nal ain Cold Foggers These foggers are obviously the opposite of thermal fogger. Instead of using heat to vaporize the pesticide solution, it uses high-pressure of air to convert the solution into tiny particles. Cold foggers have an electric motor inside its body. This determines the power of airflow that will convert the pesticide into small particles. The range of the electric motor’s power is from 1 horsepower (HP) or lower, but some might even have more than 1HP. Ultra-low volume (ULV) foggers, as the name suggests, use a low amount of fogging liquid. This results in a lower cost of application.", "domain": "chemistry", "round": 3} +{"url": "http://www.nhbs.com/epitope-mapping-protocols-book", "date": "2017-08-20T15:53:38Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-34/segments/1502886106779.68/warc/CC-MAIN-20170820150632-20170820170632-00194.warc.gz", "language_score": 0.685124397277832, "token_count": 908, "dump": "CC-MAIN-2017-34", "global_id": "webtext-fineweb__CC-MAIN-2017-34__0__254257469", "lang": "en", "text": "Overview: Choosing a Method for Epitope Mapping Glenn E. Morris. Crystallographic Studies of Antigen-Antibody Interactions Frederick A. Saul and Pedro M. Alzari. Epitope Mapping Antibody-Antigen Complexes by Nuclear Magnetic Resonance Spectroscopy Irina Kustanovich and Anat Zvi. Mapping Epitopes on Antigens by Immunodiffusion in Gel Giuseppe A. Molinaro and William C. Eby. A Simple Solid-Phase Competition Assay with Labeled Antigen Masahide Kuroki. Epitope Mapping by Antibody Competition: Methodology and Evaluation of the Validity of the Technique Socrates J. Tzartos. Epitope Mapping by Surface Plasmon Resonance in the BIAcore Berit Johne. Identifying Residues in Antigenic Determinants by Chemical Modification N. Martin Young and Raymond P. Oomen. Epitope Mapping by Differential Chemical Modification of Antigens Hans Rudolf Bosshard. Epitope Mapping by Proteolysis of Antigen-Antibody Complexes: Protein Footprinting Ronald Jemmerson. Proteolytic Fragmentation for Epitope Mapping Maria R. Mazzoni Nickolai O. Artemyev and Heidi E. Hamm. Epitope Mapping by Chemical Fragmentation Glenn E. Morris. Probing Antibody-Antigen Interactions by Mass Spectrometry Yingming Zhao and Brian T. Chait. Epitope Mapping Using Multipin Peptide Synthesis Stuart J. Rodda N. Joe Maeji and Gordon Tribbick. SPOT Synthesis: Epitope Analysis with Arrays of Synthetic Peptides Prepared on Cellulose Membranes Ronald Frank and Heike Overwin. Tea Bag Synthesis of Positional Scanning Synthetic Combinatorial Libraries and Their Use for Mapping Antigenic Determinants Clemencia Pinilla Jon R. Appel and Richard A. Houghten. Epitope Mapping Using Phage-Displayed Peptide Libraries Diane Dottavio. Reiterative Screening of Phage-Display Peptide Libraries with Antibodies Alexander Pereboev and Glenn E. Morris. Homolog Scanning Lin-Fa Wang. Epitope Mapping Using an Oligonucleotide Replacement Method Hannah Alexander. Epitope Mapping by Region-Specified PCR Mutagenesis Takehiko Shibata and Masayuki Ikeda. Random Fragment Libraries Using Yeast Expression Plasmid Serge B'nichou and GeneviSve Inchausp'. Epitope Mapping Using Random Fragment Expression Libraries in l Phages Hartmut Porzig and Kenneth D. Philipson. Random Fragment Libraries Displayed on Filamentous Phage Lin-Fa Wang and Meng Yu. Epitope Mapping by Expression of Restriction Enzyme or PCR Fragments in Bacterial Plasmids Johannes A. Lenstra and Arnoud H. M. Van Vliet. Epitope Mapping of Protein Antigens by Expression-PCR (E-PCR) David E. Lanar Kevin C. Kain and Henry B. Burch. Epitope Mapping on Extracellular Domains of Cell-Surface Proteins Using Exonuclease III Thomas Br?mmendorf Antonius Plagge and Ullrich Treubert. An Improved Method for Mapping Epitopes of Recombinant Antigens by Transposon Mutagenesis Steven G. Sedgwick Brian A. Morgan Nguyen thi Man and Glenn E. Morris. Incomplete Polypeptides of In Vitro Translation for Epitope Localization Lisa Djavadi-Ohaniance and Bertrand Friguet. T-Cell Epitope Mapping with Synthetic Peptides and Peripheral Blood Mononuclear Cells Stuart J. Rodda. Use of Natural or Selected Mutants and Variants for Epitope Mapping Glenn E. Morris. Production of Panels of Monoclonal Antibodies by the Hybridoma Method Nguyen thi Man and Glenn E. Morris. Production of Phage-Display Antibodies for Epitope Mapping Jenny Walker and George Banting. Index.", "domain": "chemistry", "round": 3} +{"url": "https://www.mdpi.com/2073-4352/9/5/239", "date": "2019-05-22T20:55:33Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-22/segments/1558232256958.53/warc/CC-MAIN-20190522203319-20190522225319-00147.warc.gz", "language_score": 0.8803111910820007, "token_count": 466, "dump": "CC-MAIN-2019-22", "global_id": "webtext-fineweb__CC-MAIN-2019-22__0__171317762", "lang": "en", "text": "Microstructure and Mechanical Properties of Aged and Hot Rolled AZ80 Magnesium Alloy Sheets\nAbstractThis study focused on the effects of ageing for various time at 175 °C before hot rolling on microstructure and mechanical properties of AZ80 magnesium alloys. The amount of γ-Mg17Al12 increased in line with ageing time and during the rolling process could facilitate the fine grains and sub-grains, which resulted in an inhomogeneous or bimodal microstructure, and weakening basal-type texture intensity or occurrence of double-peak texture. However, a larger quantity of γ-Mg17Al12 distributed on the matrix in the alloy aged for 240 min, or the precipitates decorating the grain boundaries in the alloy aged for 75 min, were detrimental to the mechanical properties, and lower ultimate tensile strength with elongation were obtained in the two alloys as a result. When the alloy was aged for 200 min, it showed an optimum mechanical property with its yield strength of 281 MPa, ultimate tensile strength of 363 MPa and a medium elongation of 13.3%, which was mainly attributed to the interaction of the hard second phase particles with dislocation movement and the lowest basal-type texture intensity that favored the basal slip. View Full-Text\nShare & Cite This Article\nHe, B.; Hu, Y.; Zhao, T.; Yao, Q.; Pan, F. Microstructure and Mechanical Properties of Aged and Hot Rolled AZ80 Magnesium Alloy Sheets. Crystals 2019, 9, 239.\nHe B, Hu Y, Zhao T, Yao Q, Pan F. Microstructure and Mechanical Properties of Aged and Hot Rolled AZ80 Magnesium Alloy Sheets. Crystals. 2019; 9(5):239.Chicago/Turabian Style\nHe, Bing; Hu, Yaobo; Zhao, Tianshuo; Yao, Qingshan; Pan, Fusheng. 2019. \"Microstructure and Mechanical Properties of Aged and Hot Rolled AZ80 Magnesium Alloy Sheets.\" Crystals 9, no. 5: 239.\nNote that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.", "domain": "chemistry", "round": 3} +{"url": "https://www.payampetro.ir/en/newsagency/25686/Iran-Petchem-Industry-Prioritizes-Safety-Int-l-Standards", "date": "2023-12-06T20:32:05Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100603.33/warc/CC-MAIN-20231206194439-20231206224439-00466.warc.gz", "language_score": 0.912289023399353, "token_count": 693, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__139232361", "lang": "en", "text": "During the 8th National Chemical Defense Conference, Morteza\nShahmirzai emphasized the nature and sensitivity of the oil, gas, refining, and\npetrochemical industries, stating that the slightest disregard for safety\nprinciples or carelessness in the operations and processing of certain\nchemicals in these industries can lead to accidents.\nHe stressed the doubled importance of enforcing chemical defense\nregulations and measures, especially in the downstream sector, including the\nShahmirzai added, \"The National Petrochemical Company has\nimplemented stringent regulations in operational areas of the petrochemical\nindustry since the past.\"\nThe CEO mentioned that around 550 grades of polymer and petrochemical\nproducts are produced in 70 active petrochemical complexes across the country.\nHe affirmed that all chemical substances manufactured in the petrochemical\nindustry are strictly dedicated to industrial applications and contribute to\nhuman progress and well-being.\nShahmirzai highlighted that the petrochemical production and complexes\nundergo regular monitoring by international bodies. He stated, \"Iran's petrochemical\nindustry is one of the largest worldwide, adhering to scientific principles and\ninternational safety standards.\"\nHe further described the installed capacity of Iran's petrochemical\nindustry, estimated at approximately 92 million tons annually. Shahmirzai\nstated, \"The management of Iran's petrochemical industry is carried out\nthrough the guidance and policies of the National Petrochemical Company, in\ncollaboration with the holdings, investors, and shareholders who strictly\nadhere to safety regulations.\"\nThe Deputy Minister of Petroleum emphasized that despite sanctions and\nlimitations, over 100 small and large petrochemical projects are currently\nbeing implemented in the country. He added, \"By the end of the seventh\ndevelopment plan, the installed capacity of Iran's petrochemical industry is\nprojected to reach approximately 135 million tons per year.\"\nShahmirzai reiterated that all quantitative and qualitative indicators\nof the eighth development plan have been defined, ensuring that by the end of\nthe plan, the installed capacity of Iran's petrochemical industry will be twice\nits current capacity, with a complete range of polymer and petrochemical\nproducts that are globally recognized.\nHe emphasized that in such a vast industry with development programs,\nchemical defense, including fundamental principles, is a crucial aspect\nconsidered in the planning and execution of petrochemical projects.\nThe CEO of the National Petrochemical Company stated, \"A 20-year\nvision for the petrochemical industry is currently being drafted to determine\nthe direction and position the industry should strive for.\"\nShahmirzai confirmed that the strategic plan for Iran's petrochemical\nindustry in the thirteenth government is being fully developed. He added,\n\"According to this plan, not only will all the world's petrochemical\nproducts be produced in Iran, but also planning will be implemented for safety\nrequirements, chemical defense, optimization, investment issues, supply chain,\ncommodities, equipment, and product marketing.\"\nThe 8th National Chemical Defense Conference, organized by the\nNon-Operational Defense Organization of the country in collaboration with the\nprivate sector, aimed to promote awareness, enhance preparedness and education,\nintroduce innovative research and technology, and honor the top achievements in\nthe field of chemical defense.", "domain": "chemistry", "round": 3} +{"url": "https://www.hirsla.lsh.is/handle/2336/621230", "date": "2022-06-25T14:56:44Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-27/segments/1656103035636.10/warc/CC-MAIN-20220625125944-20220625155944-00038.warc.gz", "language_score": 0.8901199102401733, "token_count": 1027, "dump": "CC-MAIN-2022-27", "global_id": "webtext-fineweb__CC-MAIN-2022-27__0__71061128", "lang": "en", "text": "Metabolic fate of adenine in red blood cells during storage in SAGM solution.\nCast your vote\nYou can rate an item by clicking the amount of stars they wish to award to this item.\nWhen enough users have cast their vote on this item, the average rating will also be shown.\nYour vote was cast\nThank you for your feedback\nThank you for your feedback\nSigurjónsson, Ólafur E\nPalsson, Bernhard O\nMetadataShow full item record\nCitationPaglia G, Sigurjónsson ÓE, Bordbar A, Rolfsson Ó, Magnusdottir M, Palsson S, Wichuk K, Gudmundsson S, Palsson BO. Metabolic fate of adenine in red blood cells during storage in SAGM solution. Transfusion. 2016 Oct;56(10):2538-47.\nAbstractBACKGROUND: Red blood cells (RBCs) are routinely stored and transfused worldwide. Recently, metabolomics have shown that RBCs experience a three-phase metabolic decay process during storage, resulting in the definition of three distinct metabolic phenotypes, occurring between Days 1 and 10, 11 and 17, and 18 and 46. Here we use metabolomics and stable isotope labeling analysis to study adenine metabolism in RBCs. STUDY DESIGN AND METHODS: A total of 6 units were prepared in SAGM or modified additive solutions (ASs) containing 15 N5 -adenine. Three of them were spiked with 15 N5 -adenine on Days 10, 14, and 17 during storage. Each unit was sampled 10 times spanning Day 1 to Day 32. At each time point metabolic profiling was performed. RESULTS: We increased adenine concentration in the AS and we pulsed the adenine concentration during storage and found that in both cases the RBCs' main metabolic pathways were not affected. Our data clearly show that RBCs cannot consume adenine after 18 days of storage, even if it is still present in the storage solution. However, increased levels of adenine influenced S-adenosylmethionine metabolism. CONCLUSION: In this work, we have studied in detail the metabolic fate of adenine during RBC storage in SAGM. Adenine is one of the main substrates used by RBCs, but the metabolic shift observed during storage is not caused by an absence of adenine later in storage. The rate of adenine consumption strongly correlated with duration of storage but not with the amount of adenine present in the AS.\nDescriptionTo access publisher's full text version of this article click on the hyperlink below\nRights© 2016 AABB.\n- Metabolomics of ADSOL (AS-1) red blood cell storage.\n- Authors: Roback JD, Josephson CD, Waller EK, Newman JL, Karatela S, Uppal K, Jones DP, Zimring JC, Dumont LJ\n- Issue date: 2014 Apr\n- Prevention of red cell storage lesion: a comparison of five different additive solutions.\n- Authors: Lagerberg JW, Korsten H, Van Der Meer PF, De Korte D\n- Issue date: 2017 Sep\n- Modified formulation of CPDA for storage of whole blood, and of SAGM for storage of red blood cells, to maintain the concentration of 2,3-diphosphoglycerate.\n- Authors: Kurup PA, Arun P, Gayathri NS, Dhanya CR, Indu AR\n- Issue date: 2003 Nov\n- Stored red blood cell susceptibility to in vitro transfusion-associated stress conditions is higher after longer storage and increased by storage in saline-adenine-glucose-mannitol compared to AS-1.\n- Authors: Mittag D, Sran A, Chan KS, Boland MP, Bandala-Sanchez E, Huet O, Xu W, Sparrow RL\n- Issue date: 2015 Sep\n- In vitro measures of membrane changes reveal differences between red blood cells stored in saline-adenine-glucose-mannitol and AS-1 additive solutions: a paired study.\n- Authors: Sparrow RL, Sran A, Healey G, Veale MF, Norris PJ\n- Issue date: 2014 Mar", "domain": "chemistry", "round": 3} +{"url": "https://digitalcommons.usu.edu/microscopy/vol5/iss3/8/", "date": "2023-06-10T11:58:46Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-23/segments/1685224657169.98/warc/CC-MAIN-20230610095459-20230610125459-00188.warc.gz", "language_score": 0.8381562232971191, "token_count": 360, "dump": "CC-MAIN-2023-23", "global_id": "webtext-fineweb__CC-MAIN-2023-23__0__17446331", "lang": "en", "text": "Cryotechniques must be employed throughout all preparation and observation steps in order to extract high resolution scanning electron microscopical information from biological material.\nCryoimmobilization, followed by freeze-drying and metal-shadowing at low temperature, yields optimal structural information of T4 polyheads used as a test specimen. Freeze-substitution of frozen T4 polyheads and subsequent freeze-drying renders the substructures recognizable but less crisp than freeze-drying from aequous solutions. Critical point drying of ethanol dehydrated chemically fixed, or freeze-substituted test specimens results in complete loss of discrete polyhead structure.\nIn-lens field-emission scanning electron microscopes and highly sensitive electron detectors are instrumental prerequisites in achieving transmission electron microscope-like resolution of structural details. Shape and size of fine structures, of the test specimen, are accurately imaged at high acceleration voltage ( > 7 kV). Precise localization of antigenic sites via ultra-small (0.8 nm) colloidal gold marker systems by backscattered electrons also depends on the appropriate choice of acceleration voltage.\nContamination of the specimen surface is a serious problem in high resolution scanning electron microscopy. It can be controlled in practice, by photographing selected areas of cooled specimens during the first scan of the electron beam.\nHermann, René and Müller, Martin\n\"Prerequisites of High Resolution Scanning Electron Microscopy,\"\nScanning Microscopy: Vol. 5:\n3, Article 8.\nAvailable at: https://digitalcommons.usu.edu/microscopy/vol5/iss3/8", "domain": "chemistry", "round": 3} +{"url": "https://matbio.org/article.php?journ_id=31&id=383&lang=eng", "date": "2024-04-16T20:16:49Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712296817106.73/warc/CC-MAIN-20240416191221-20240416221221-00576.warc.gz", "language_score": 0.906545102596283, "token_count": 401, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__86348513", "lang": "en", "text": "Simulation of Buffered Advection Diffusion of Calcium in a Hepatocyte Cell\nJagtap Y.D., Adlakha N.\nAMHD, S. V. National Institute of Technology, Surat, Gujarat , India\nAbstract. The calcium signaling is the basic and vital component of cell communication in almost all types of human and animal cells. All the vital functions of parenchymal cell of liver known as hepatocyte cell are regulated by this calcium signaling. The calcium concentration at specific levels are responsible for each of the various functions of the cell. The deeper understanding of the mechanisms and the factors affecting the calcium dynamics in a hepatocyte cell is vital for various clinical applications related to diseases of the liver. In this paper, mathematical model is proposed to study intracellular calcium dynamics in hepatocyte cell by incorporating the processes like diffusion, advection, buffering etc. The reaction advection diffusion equation has been employed for a two dimensional unsteady state case, to form an initial and boundary value problem. The initial and boundary conditions are formulated based on the physical conditions of cell. Finite volume method and Crank Nicolson scheme have been employed along spatial and temporal dimension respectively to obtain numerical solution. The impact of endogenous and exogenous buffers, advection and diffusion on calcium dynamics in hepatocyte cell has been studied with the help of numerical results. The rise and fall in spatio-temporal calcium concentration in hepatocyte cell in response to specific conditions of advection, diffusion and buffer concentrations is observed. These variations in spatio-temporal calcium concentrations are regulated in narrow range due to fine coordination among these processes of cell under normal environmental and physiological conditions. The proposed model gives better understanding of interrelationship and interdependence of these physical processes for fine coordination among them to maintain structure and functions of cell.\nKey words: hepatocyte cell, advection, diffusion, calcium, buffer, finite volume method.", "domain": "chemistry", "round": 3} +{"url": "https://repository.kaust.edu.sa/handle/10754/630480", "date": "2022-08-15T03:35:00Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882572127.33/warc/CC-MAIN-20220815024523-20220815054523-00689.warc.gz", "language_score": 0.8555558919906616, "token_count": 609, "dump": "CC-MAIN-2022-33", "global_id": "webtext-fineweb__CC-MAIN-2022-33__0__58767199", "lang": "en", "text": "Statistics of scalar dissipation and reaction progress in turbulent flames with compositional inhomogeneities\nKAUST DepartmentClean Combustion Research Center\nMechanical Engineering Program\nPhysical Science and Engineering (PSE) Division\nOnline Publication Date2018-06-18\nPrint Publication Date2018-08\nPermanent link to this recordhttp://hdl.handle.net/10754/630480\nMetadataShow full item record\nAbstractThis paper presents detailed measurements of three-dimensional (3D) scalar dissipation rates collected in turbulent, piloted flames with varying degree of compositional inhomogeneity. Joints statistics of mixture fraction and reaction progress variable are also shown for a range of conditions. These measurements complement the already existing substantial data set for mixed-mode flames stabilized on the Sydney piloted burner with compositionally inhomogeneous inlets. It is found that the difference between 2D (χ) and 3D (χ) scalar dissipation increases with axial distance along the flame such that the ratio χ/χ may be as high as 2.6. The effects of spatial resolution become more significant as compositional inhomogeneity increases. Mixture fraction, ξ is well-correlated with reaction progress variable, c, in turbulent homogenous flames but the correlations deteriorates significantly as the compositional inhomogeneity increases. This transition should clearly be accounted for in modeling mixed-mode combustion. A new mode of conditioning the scalar dissipation data with respect to burnt and unburnt fluid samples reveal separate trends: while the levels of χ remain similar for burnt samples, unburnt fluid experiences increasing levels of χ as the flames approach blow-off.\nCitationCutcher HC, Barlow RS, Magnotti G, Masri AR (2018) Statistics of scalar dissipation and reaction progress in turbulent flames with compositional inhomogeneities. Combustion and Flame 194: 439–451. Available: http://dx.doi.org/10.1016/j.combustflame.2018.05.030.\nSponsorsWork at the University of Sydney was supported by the Australian Research Council. Work at Sandia was supported by the Division of Chemical Sciences, Geosciences and Biosciences, Office of Basic Energy Sciences, US Department of Energy. Sandia National Laboratories is a multi-mission laboratory managed and operated by National Technology and Engineering Solutions of Sandia, LLC., a wholly owned subsidiary of Honeywell International, Inc., for the U.S. Department of Energy's National Nuclear Security Administration under contract DE-NA-0003525. Contributions by Bob Harmon in support of these experiments are gratefully acknowledged.\nJournalCombustion and Flame", "domain": "chemistry", "round": 3} +{"url": "https://www.dmt-group.com/news-info/press/press-release/archive/dmt-supports-prototyping-the-use-of-low-calorific-coal-mine-methane-cmm.html", "date": "2021-08-05T00:16:00Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-31/segments/1627046155268.80/warc/CC-MAIN-20210805000836-20210805030836-00496.warc.gz", "language_score": 0.8767194747924805, "token_count": 527, "dump": "CC-MAIN-2021-31", "global_id": "webtext-fineweb__CC-MAIN-2021-31__0__111962882", "lang": "en", "text": "Greenhouse Gas CMM outgasses from old coal mines into the atmosphere. Up to now, this gas is burned in gas piston engines at many locations and is used to generate electricity. This usage cases decline as methane concentrations are slowly decreasing and the gas piston engines cannot run below appr. 18% methane by volume. In the \"LowCH4-MDT Module\" project, Fraunhofer UMSICHT, DMT and the Herne municipal utilities (Stadtwerke Herne) are testing a new technological utilization chain with a special lean gas burner for mine gas with less than 18% methane by volume, a steam boiler and micro steam turbine for power and heat generation in order to continue to avoid Greenhouse Gas emissions.\nFor utilization of coal mine methane (CMM) below 18% by volume methane concentration there are currently no economically viable technologies available. In order to avoid the emission of considerable amounts of greenhouse gas in the long term, the \"LowCH4-MDT-Module\" project aims to develop, build and demonstrate a prototype of a modular plant with a lean gas burner, steam boiler and micro steam turbine. This prototype should enable a reliable utilization of CMM between five and 18 vol. % CH4 and thus further avoid CH4 emissions of today's approx. 270 million Nm³/a (corresponding to 3.6 million tCO2 eq/a) for at least another decade.\nFor this purpose, the specification of a corresponding plant is derived by analyzing site data of CMM utilizations in the Ruhr Area. Based on this, the modular prototype will be designed, developed, planned, built and commissioned, optimized and put into trial operation at a CMM site of Stadtwerke Herne AG. Based on the technical and economic results, the potential of further use at CMM sites in the Ruhr Area will be evaluated.\n- Fraunhofer UMSICHT (funded): www.umsicht.fraunhofer.de\n- Stadtwerke Herne AG (associated): www.stadtwerke-herne.de\nJanuary 2019 to December 2021 (extension planned)\nThe project \"Prototype development and trial operation for the utilization of low calorific CMM with methane contents between 5 % and 18 % by volume by lean gascombustion, steam generation and micro steam turbine\" (LowCH4-MDT module) is funded by the European Regional Development Fund (ERDF).\nTel: +49 201 172-1097", "domain": "chemistry", "round": 3} +{"url": "https://digitalcommons.uri.edu/gsofacpubs/1613/", "date": "2024-02-24T15:01:59Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707947474541.96/warc/CC-MAIN-20240224144416-20240224174416-00813.warc.gz", "language_score": 0.8335970044136047, "token_count": 435, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__167941284", "lang": "en", "text": "Prediction of magmatic water contents via measurement of H2O in clinopyroxene phenocrysts\nDate of Original Version\nWater is fundamental to magma genesis, evolution, and eruption. Few direct measurements of magmatic H2O exist, however, because rocks found at the surface have extensively degassed upon eruption. Olivine-hosted melt inclusions provide a standard approach to measuring volatiles in undegassed magma, but many volcanic deposits do not contain melt inclusions large enough for analysis (>30 μm), or olivine at all. Here we use an AlIV-dependent partitioning relationship to calculate magmatic H2O from direct measurements of H2O in clinopyroxene phenocrysts. We test this approach using phenocrysts from four arc volcanoes (Galunggung, Irazú, Arenal, and Augustine) that span the global range in H2O contents as measured in olivine-hosted melt inclusions (from 0.1 to 7 wt% H2O). The average and maximum magmatic H2O contents calculated from the clinopyroxene measurements agree within 15% of the melt inclusion values for most of the samples. The evolutionary paths recorded in H2O-Mg# variations overlap in some clinopyroxene and olivine-hosted melt inclusion populations, and in others, the clinopyroxenes record a larger portion of the liquid line of descent or a different portion of the magma system. Thus, the use of phenocrysts to estimate magmatic H2O contents creates a new and powerful tool in igneous petrology and volcanology. © 2008 The Geological Society of America.\nPublication Title, e.g., Journal\nWade, Jennifer A., Terry Plank, Erik H. Hauri, Katherine A. Kelley, Kurt Roggensack, and Mindy Zimmer. \"Prediction of magmatic water contents via measurement of H2O in clinopyroxene phenocrysts.\" Geology 36, 10 (2008). doi: 10.1130/G24964A.1.", "domain": "chemistry", "round": 3} +{"url": "https://www.astm.org/Standards/F2718.htm", "date": "2017-01-21T11:09:04Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-04/segments/1484560281069.89/warc/CC-MAIN-20170116095121-00127-ip-10-171-10-70.ec2.internal.warc.gz", "language_score": 0.8522363305091858, "token_count": 622, "dump": "CC-MAIN-2017-04", "global_id": "webtext-fineweb__CC-MAIN-2017-04__0__152599503", "lang": "en", "text": "| ||Format||Pages||Price|| |\n|4||$40.00||  ADD TO CART|\n|Hardcopy (shipping and handling)||4||$40.00||  ADD TO CART|\n1.1 This specification covers requirements and test methods for materials for a semi-structural polyethylene (PE) encapsulated cement mortar formed-in-place liner system (FIPLS) intended for the rehabilitation of water pipelines of nominal size 4 in. to 12 in. This renewal process involves installing a collapsed PE liner, folded at the time of insertion, into an existing pipeline, expanding the PE liner, and then pumping cement mortar into the annulus between the liner and the main.\n1.2 The liner and cement mortar are progressively rounded by means of an air pressure propelled pig and expanded against the interior surface of the original host pipe. After rounding, the line is maintained under pressure until the cement mortar cures and the liner is completely self supporting.\n1.3 The values stated in inch-pound units are to be regarded as standard. The values given in parentheses are mathematical conversions to SI units that are provided for information only and are not considered standard.\n1.4 This standard does not purport to address all of the safety concerns, if any, associated with its use. It is the responsibility of the user of this standard to establish appropriate safety and health practices and determine the applicability of regulatory limitations prior to use.\n1.5 There is no similar or equivalent ISO standard.\n2. Referenced Documents (purchase separately) The documents listed below are referenced within the subject standard but are not provided as part of the standard.\nC109/C109M Test Method for Compressive Strength of Hydraulic Cement Mortars (Using 2-in. or [50-mm] Cube Specimens)\nD638 Test Method for Tensile Properties of Plastics\nD790 Test Methods for Flexural Properties of Unreinforced and Reinforced Plastics and Electrical Insulating Materials\nD1505 Test Method for Density of Plastics by the Density-Gradient Technique\nD1525 Test Method for Vicat Softening Temperature of Plastics\nD1600 Terminology for Abbreviated Terms Relating to Plastics\nD1693 Test Method for Environmental Stress-Cracking of Ethylene Plastics\nF412 Terminology Relating to Plastic Piping Systems\nICS Number Code 91.100.10 (Cement. Gypsum. Lime. Mortar)\n|Link to Active (This link will always route to the current Active version of the standard.)|\nASTM F2718-09(2015), Standard Specification for Polyethylene (PE) and Cement Materials for an Encapsulated Cement Mortar Formed in Place Liner System (FIPLS) for the Rehabilitation of Water Pipelines, ASTM International, West Conshohocken, PA, 2015, www.astm.orgBack to Top", "domain": "chemistry", "round": 3} +{"url": "https://www.orbtronic.com/batteries-chargers/ultra-portable-li-ion-cr123-or-cr2-fast-battery-charger-usb-wall-car-adapters-xtar-mp2/", "date": "2023-04-01T05:28:07Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-14/segments/1679296949701.0/warc/CC-MAIN-20230401032604-20230401062604-00613.warc.gz", "language_score": 0.7922732830047607, "token_count": 271, "dump": "CC-MAIN-2023-14", "global_id": "webtext-fineweb__CC-MAIN-2023-14__0__279738627", "lang": "en", "text": "Fast CR123 or CR2 li-ion battery charger.\nUltra portable with USB interface.\nSwitch [3.0V - 3.7V] is built in, so correct charging voltage is supplied to the 3.0V or 3.7V li-ion battery.\nXtar MP2 Li-ion battery charger is very easy, and safe to operate.\nCharge RCR123 or CR2 Li-ion rechargeable batteries from: PC, Laptop, Wall adapter (not included, but you can use your cell phone standard USB adapter).\nSupported Li-ion rechargeable batteries:\nRCR123 3.0V ( 3.2V/3.3V LiFePO4 )\nRCR123 3.7V (Also called 16340)\nCR2 3.0V ( 3.2V/3.3V LiFePO4 )\nCR2 3.7V (Also called 15270)\nWhat is in the box?\n1x Charging unit\n2x Contact Spacers (When charging smaller batteries like CR2 li-ion rechargeables)\n1x USB Cable\n1x User Manual\n1x Warranty card\nNever try to charge regular (one time use) CR123A or CR2 non-rechargeable lithium batteries.", "domain": "chemistry", "round": 3} +{"url": "https://profiles.ouhsc.edu/search/default.aspx?searchtype=whypeople&nodeuri=https://profiles.ouhsc.edu/profile//214776&searchfor=Single-Cell%20Analysis&exactphrase=false&perpage=15&offset=0&page=1&totalpages=6&searchrequest=A81BSfTwU3GNm4liSODkW6vB3EBYO6gz+a5TY1bFhuysXK4hqbI6eAebHoNTzab0+VLZJkUtJQj+YJ6aI0ZcHxfEXvx5nR5TiH8/Cw9XBVdG3App14aWMr2hZ8qtJ94eCsv7K32uLwJrnur5IbaEcJaKK0HiLuh99bXO54C+Dq8MN9OuCqKrhv/QtV0VC1l/tncZFI6GsA7IpJFAbogWvUSniam10xyZzMtUtPFkvKSqnPEO7gfPsl3taATzidUkHiA5/1D/YFLtyfQuU1EJK8mZk0QlNEbahfDRk6WWacn5+oDlZTICP7lyxuKVCYo0Bx+x5r48GkHfBxeboJgbTH5g22pnI2QrhE1ONCJ9I42wxWAU9A2KJz+y4N4vC3lGjZuJYkjg5FuVT9e2f9vVhZ2bO89nzUR1&sortby=&sortdirection=&showcolumns=1", "date": "2023-09-25T17:31:04Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233509023.57/warc/CC-MAIN-20230925151539-20230925181539-00313.warc.gz", "language_score": 0.6851055026054382, "token_count": 280, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__176762837", "lang": "en", "text": "to edit your profile (add a photo, awards, links to other websites, etc.)\nEdit My Profile\nMy Person List (\nReturn to Top\nSearch Result Details\nBack to Search Results\nThis page shows the details of why an item matched the keywords from your search.\nOne or more keywords matched the following items that are connected to\nQuantification of Drug Molecules in Live Single Cells Using the Single-Probe Mass Spectrometry Technique.\nIntegrated Cell Manipulation Platform Coupled with the Single-probe for Mass Spectrometry Analysis of Drugs and Metabolites in Single Suspension Cells.\nThe single-probe: a miniaturized multifunctional device for single cell mass spectrometry analysis.\nMass Spectrometry Measurement of Single Suspended Cells Using a Combined Cell Manipulation System and a Single-Probe Device.\nMass Spectrometry Detection of Drugs in Single Bladder Cancer Cells from Patients\nSingle Cell Analysis", "domain": "chemistry", "round": 3} +{"url": "https://artearth.ru/radiometric-dating-of-rock-strata-119.html", "date": "2021-07-24T02:11:28Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-31/segments/1627046150067.87/warc/CC-MAIN-20210724001211-20210724031211-00563.warc.gz", "language_score": 0.9485630393028259, "token_count": 323, "dump": "CC-MAIN-2021-31", "global_id": "webtext-fineweb__CC-MAIN-2021-31__0__288955272", "lang": "en", "text": "Radiometric dating of rock strata Horny chat rooms fake\nThe claimed “fact” that decay rates have always been constant is actually an inference based on a uniformitarian assumption.It is true that radioisotope decay rates are stable today and are not largely affected by external conditions like change in temperature and pressure, but that does not mean that the rate has always been constant.It is possible to measure the ratio of the different radioactive parent isotopes and their daughter isotopes in a rock, but the ratios are not dates or ages.The dates must be inferred based on assumptions about the ratios.If any of these three conditions is not accurately known, the hourglass will give an inaccurate measure of time.Radiometric dating is based on the fact that radioactive isotopes decay to form isotopes of different elements.Uniformitarian geologists use so-called dating methods to determine the ages of the surrounding rocks.\nThe Bible gives a much different picture and explains that relying on man’s reasoning is foolishness.\nThere are three main assumptions that must be made to accept radiometric dating methods.\nThese must be accepted on faith in uniformitarian and naturalistic frameworks.\nMost scientists and many Christians believe that the radiometric dating methods prove that the earth is 4.5 billion years old.\nThe textbooks speak of the radiometric dating techniques, and the dates themselves, as factual information.\nKnowing this first: that scoffers will come in the last days, walking according to their own lusts, and saying, “Where is the promise of His coming?", "domain": "chemistry", "round": 3} +{"url": "https://www.nanopaprika.eu/members/MSAbdElsadek", "date": "2023-12-06T01:27:38Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100575.30/warc/CC-MAIN-20231206000253-20231206030253-00508.warc.gz", "language_score": 0.7054843902587891, "token_count": 1738, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__25480192", "lang": "en", "text": "My research field or area of interest innanotechnology\n1- Growth of Single Crystals (Semiconductor Materials) by Bridgman Technique, Czochralski Technique and Chemical Vapor Deposition (CVD), .. etc. 2- Measurements of the electrical conductivity and Hall coefficient. 3- Measurements of the thermoelectrical power. 3- Study of Switching Phenomena. 4- Measurements of Photoconductivity. 5- Preparation of Semiconductor and Metallic Nanoparticles by Physical and Chemical methods. 6- Preparatrion of Nano-Crystalline Thin Films by Thermal Evaportion, E-beam Evaportion and Spin Coating System for Solar Cell Applications. 7- Study of Structural Propertries by X-ray Diffraction System and EDAX Analysis. 8- Microscopy Techniques including high-resolution TEM, SEM and Scanning Probe Microscopy Techniques such as, AFM and STM. 9- Optical Properties such as, UV-Visible Absorption and Fluorescence Spectroscopy. 10- Thermal Analysis Techniques such as, TGA/DTA and DSC. 11- Spectroscopic Techniques such as, FT-IR and Raman Spectroscopy. 12- Electron paramagnetic Resonance (EPR) Analysis.\nSolid State Physics, Semiconductors Materials, Crystal growth, Single Crystals, The synthesis and Characterization of Semiconductor and Metallic Nanocrystals and Their Applications in Solar Cell and Biological Labels.\nInternational Journals 1. “Transport Properties of Bi2S3 Single Crystals” H. T. Shaban, M. M. Nassary, and M. S. El-sadek Physica B : Condensed Matter, (2008), Vol. 403, pp. 1655-1659. 2. “Semiconductor Parameters of Bi2Te3 Single Crystal” M. M. Nassary, H. T. Shaban, and M. S. El-sadek Materials Chemistry and Physics, (2009), Vol. 113, pp. 385-389. 3. “Optical Properties of Thiol-Stabilized CdTe Nanoparticles” M. S. Abd El-sadek, J. Ram kumar, and S. Moorthy Babu International Journal of Nanoparticles, (2009), Vol. 2, pp. 20-29. 4. “The role of Potassium Tellurite as Tellurium Source in Mercaptoacetic- Acid-Capped CdTe Nanoparticles” M. S. Abd El-sadek, J. Ram kumar, and S. Moorthy Babu Current Applied Physics, (2010), Vol. 10, pp. 317-322. 5. “Selective Synthesis and Characterization of CdTe@Mn(OH)2 (Core-Shell) Composite Nanoparticles” M. S. Abd El-sadek, J. Ram Kumar, S. Moorthy Babu, and M. Salim El-Hamidy Journal of Alloys and Compounds, (2010), Vol. 496, pp. 589-594. 6. “Synthesis and Optical Characterization of Nanocrystalline CdTe Thin Films” A.A. Al-Ghamdi, Shamshad A. Khan, A. Nagat, and M.S. Abd El-Sadek Optics & Laser Technology, (2010), Vol. 42, pp. 1181-1186. Top 25 Hottest Articles Physics and Astronomy > Optics & Laser Technology July to September 2010 (http://top25.sciencedirect.com/subject/physics-and-astronomy/21/journal/optics-laser-technology/00303992/archive/28) 7. “Growth and Optical Characterization of Colloidal CdTe Nanoparticles Capped by a bifunctional Molecule” M. S. Abd El-sadek and S. Moorthy Babu Physica B: Condensed Matter (2010), Vol. 405, pp. 3279-3283. 8- “Aqueous Synthesis and Characterization of CdTe@Co(OH)2 (Core-Shell) Composite Nanoparticles” M. S. Abd El-sadek and S. Moorthy Babu Materials Chemistry and Physics ( 2010), Vol. 124, pp. 592-599. 9- “Photoinduced interaction of MPA-capped CdTe quantum dots with denatured Bovine Serum Albumin” Mariadoss Asha Jhonsi, Arunkumar Kathiravana, Rajalingam Renganathana and M.S. Abd El-sadek Nanoscience and Nanotechnology Letters (2011) Vol. 3, pp. 125-130. 10- “A Controlled Approach for Synthesizing CdTe@CrOOH (Core-Shell) Composite Nanoparticles” M. S. Abd El-sadek and S. Moorthy Babu Current Applied Physics (2011), Vol. 11, pp. 926-932. 11- “Influence of Different Stabilizers on the Optical and Nonlinear Optical Properties of CdTe Nanoparticles” M. S. Abd El-sadek, Ahmad Y. Nooralden, S. Moorthy Babu and P. K. Palanisamy Optics Communications (2011), Vol. 284, pp. 2900-2904. 12- “CdTe@Cu(OH)2 Nanocomposite: Aqueous Synthesis and Characterization” M. S. Abd El-sadek and S. Moorthy Babu Journal of Solid State Chemistry (Accepted March 2011) 13- “Electronic transport and conduction mechanism of CdTe nanocrystals” M. S. Abd El-sadek, I.S. Yahia and A.M. Salem Submitted to Materials Chemistry and Physics (October 2010) 14- “Synthesis and Semiconducting Properties of Nanocrystalline ZnO:ZnFe2O4 Composite Semiconductors by Sol-Gel Calcination Method” C. Aydın, M. S. Abd El-sadek, Kaibo Zheng, F. Yakuphanoglu, I. S. Yahia and W. A. Farooq Submitted to Journal of Solid State Chemistry (January 2011) 15. “Method Methyl orange (C.I. Acid Orange 52) as a new Organic Semiconductor: Conduction Mechanism and Dielectrical Relaxation Mechanism” I. S. Yahia, M. S. Abd El-sadek and F. Yakuphanoglu Submitted to Dyes and Pigments (February 2011) 16. “Structural Properties and Transport Mechanisms of Thermally Vacuum Evaporated CdTe Nanocrystalline Thin Films” A. Al-Ghamdi, M. S. Abd El-sadek, A. Nagat and F. El-Tantawy Submitted to Current Applied Physics (February 2011) 17. “Investigation of Linear and Nonlinear Optical Properties of Mercaptoacetic Acid-Capped CdTe Nanoparticles by Z-scan Technique” M. S. Abd El-sadek, S. Moorthy Babu, Ahmad Y. Nooralden and P. K. Palanisamy Submitted to Materials Science and Engineering B (March 2011)\nResearchgroup, Institute, University, School, Company name\nNanomaterial Laboratory, Physics Department, Faculty of Sciences, South Valley University, Qena-83523, Egypt. www.svu.edu.eg/faculties/science/cvs/phys/SV_FSCN_Phsc_SPHYS_mahmoud.abdelsadek_E.pdf\nResearchgroup, Institute, Company, University, School webpage\nThe network creator will send periodical messages to members - you below to allow us to email you", "domain": "chemistry", "round": 3} +{"url": "http://calendariu.com/a/all-colors-of-garnets.html", "date": "2017-10-22T17:22:03Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-43/segments/1508187825399.73/warc/CC-MAIN-20171022165927-20171022185927-00403.warc.gz", "language_score": 0.7035670876502991, "token_count": 300, "dump": "CC-MAIN-2017-43", "global_id": "webtext-fineweb__CC-MAIN-2017-43__0__31855080", "lang": "en", "text": "For sale garnet group minerals: - john betts, For sale garnet group minerals: grossular, andradite, melanite, uvarovite, almandine (almandite), spessartine (spessartite), demantoid, topazolite. Garnet: mineral garnet information pictures, The garnets are important minerals, and are primarily known for their gemstone uses. the transparent varieties are used in all forms of jewelry, with the most. Birthstone colors month - bernardine, A color chart of all the modern, traditional, zodiac, sun/star and ancient birthstone colors by month..\nAmethyst galleries - garnet group, The general formula garnets 3 2 (sio 4) 3. represents divalent metals calcium, iron, magnesium / manganese.. http://www.galleries.com/Garnet_Group Garnet - wikipedia, Garnets ( / ˈ ɡ ɑː ɪ /) group silicate minerals bronze age gemstones abrasives. species garnets possess. https://en.wikipedia.org/wiki/Garnet Garnet: mineral, gem, abrasive, filter !, Gem garnets: people garnet red gemstone. , garnet occurs wide variety colors. clockwise top left: red almandine. http://geology.com/minerals/garnet.shtml", "domain": "chemistry", "round": 3} +{"url": "http://www.salvavidaspharma.com/apiproducts/entacapone/", "date": "2021-04-18T05:03:31Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-17/segments/1618038468066.58/warc/CC-MAIN-20210418043500-20210418073500-00055.warc.gz", "language_score": 0.7343938946723938, "token_count": 596, "dump": "CC-MAIN-2021-17", "global_id": "webtext-fineweb__CC-MAIN-2021-17__0__15621490", "lang": "en", "text": "This medication is used with other medications (levodopa/carbidopa) to treat Parkinson’s disease. Entacapone belongs to a class of drugs known as COMT inhibitors.\n|Appearance||Greenish yellow to yellow crystalline powder||Yellow crystalline powder|\n|Identification by IR||Test IR spectrum should be concordant with reference spectrum||Complies|\n|Solubility||Sparingly soluble in acetone and methanol; slightly soluble in ethanol, chloroform, isopropanol, and ether, very slightly soluble in toluene; practically in water||Complies|\n|Loss on drying||0.5%max||0.35%|\n|Heavy metals||Not more than 20ppm||<20ppm|\n|Residue on ingition||Not more than 0.1%||0.06%|\nOther unknown impurity\nTotal impurity except Impurity A\n|Assay(on dry basis)||98.0%-102.0%||99.91%|\n|Particle size||D90: less than 10microns||8microns|\n|Storage||Cool and dry|\n|Conclusion:||Up to the Standard of USP34|\n|Packaging details:||25kg/drum with double plastic bags inside; packed in a cardboard drum or fiber HDPE drum.|\n|Storage:||Stored in a clean, cool, dry area; keep away from moisture and strong, direct light/heat|\n|Shelf Life:||5 years if sealed and store away from direct sun light.|\nThe most widely recognized markets for this item incorporate the accompanying nations. If you don’t mind ask with us if your nation or district isn’t recorded:\nASIA: Afghanistan, Israel, Jordan, Pakistan, Russia, Saudi Arabia, Singapore, Syria, Philippines, Turkey, Turkmenistan, Uzbekistan, Yemen, Vietnam, Indonesia, Malaysia, Iran, Tajikistan, and so forth.\nAFRICA: South Africa, Uganda, Nigeria, Ghana, Kenya, Mauritius, Botswana, Egypt, Ethiopia, Libya, Sudan, Congo, Gambia, Ivory Coast , and so forth.\nNORTH & SOUTH AMERICA: USA, Canada, Panama, Trinidad and Tobago, Costa Rica, Puerto Rico, Dominican Republic, Argentina, Guatemala, Guyana, Peru, Bolivia, Venezuela , Brazil, Bahamas, Ecuador, and so forth .\nEUROPE: Austria , Azerbaijan, Belarus, Belgium, Cyprus, Czech Republic, Denmark, France, Georgia, Germany, Hungary, Ireland, Iceland, Netherlands, Norway, Poland, Spain, Sweden, Switzerland, Ukraine, United Kingdom (UK) , Latvia, and so forth.\nOCEANIA: Australia, New Zealand, Fiji, and so forth.", "domain": "chemistry", "round": 3} +{"url": "https://labnodes.vanderbilt.edu/member/publication/id/11078/keyword_id/17522/keyword_name/Erythrocyte%20Membrane/pmid/3543333", "date": "2021-04-11T13:00:53Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-17/segments/1618038062492.5/warc/CC-MAIN-20210411115126-20210411145126-00254.warc.gz", "language_score": 0.9592415690422058, "token_count": 348, "dump": "CC-MAIN-2021-17", "global_id": "webtext-fineweb__CC-MAIN-2021-17__0__50096212", "lang": "en", "text": "Follicles were collected from cows and processed for electron microscopy and for immunofluorescent staining at the light microscope level. Key regulatory steroidogenic enzymes cholesterol side-chain-cleavage cytochrome P-450 (P-450scc) and 17 alpha-hydroxylase cytochrome P-450 (P-45017 alpha) were immunolocalized using specific IgG fractions raised against these enzymes. In larger follicles in which the theca interna had differentiated, positive staining for cytochromes P-450scc and P-450(17) alpha was observed in the cells of the theca interna. Electron microscopic examination showed that these cells were rich in endoplasmic reticulum, mainly rough, and had moderate numbers of mitochondria with tubular and lamellar cristae. Positive staining was also present in the theca of follicles undergoing atresia. Positive staining for cytochrome P-450(17) alpha was not observed in the membrana granulosa but cytochrome P-450scc was present in the membrana granulosa in some follicles, particularly in the larger antral follicles. By contrast, positive staining for both enzymes was not observed in stroma, surface epithelium or in small preantral follicles in which the theca interna had not differentiated. These results indicate good agreement between the type(s) of steroidogenic enzyme(s) present in tissues and the type(s) of steroid hormone(s) produced. It is concluded that regulation of steroid hormone production involves, at least in part, regulation of the levels of steroidogenic enzymes.", "domain": "chemistry", "round": 3} +{"url": "https://news.agropages.com/News/NewsDetail---40972.htm", "date": "2022-12-08T19:04:46Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-49/segments/1669446711360.27/warc/CC-MAIN-20221208183130-20221208213130-00120.warc.gz", "language_score": 0.9039195775985718, "token_count": 364, "dump": "CC-MAIN-2022-49", "global_id": "webtext-fineweb__CC-MAIN-2022-49__0__12125167", "lang": "en", "text": "Nov. 12, 2021\nOn November 8, Changqing (Hubei) Biotech held a production opening ceremony. In July 2020, Changqing launched its 5th production base in Baiyang Industrial Park, Yichang High-Tech Zone, Hubei Province, China, at a total investment of RMB 2.5 billion (two phases) taking a land are of 416 mu (1 hectare = 15 mu). After 15-month construction, the project phase I is about to run, which becomes Changqing’s largest and state-of-the-art production base. The operation of the Yichang project will enrich the product structure and extend the industrial chain of Changqing, which will facilitate more intensified and higher-level cooperation between Changqing and customers at home and abroad.\nChangqing (Hubei) Biotech is a wholly owned subsidiary of Jiangsu Changqing. Upon completion of Phase I, the company will be able to produce annually 2,000 tons of lambda-cyhalothrin technical, 1,000 tons of bifenthrin technical, 2,000 tons of fomesafen technical, 500 tons of nicosulfuron technical, 1,600 tons of diafenthiuron technical, 600 tons of fipronil technical, 3,000 tons of thiamethoxam technical, 1,500 tons of acetamiprid technical, 500 tons of fluazinam technical, 1,000 tons of chlorantraniliprole technical, 6,500 tons of benzofuran and 2,000 tons of 2,6-diisopropylaniline, totaling to 13,700 tons of pesticide technicals and 8,500 tons of chemicals per year.", "domain": "chemistry", "round": 3} +{"url": "http://scitation.aip.org/content/asa/journal/jasa/128/6/10.1121/1.3500671", "date": "2013-12-13T17:34:10Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2013-48/segments/1386164965557/warc/CC-MAIN-20131204134925-00053-ip-10-33-133-15.ec2.internal.warc.gz", "language_score": 0.6522975564002991, "token_count": 1629, "dump": "CC-MAIN-2013-48", "global_id": "webtext-fineweb__CC-MAIN-2013-48__0__8542149", "lang": "en", "text": "No data available.\nPlease log in to see this content.\nYou have no subscription access to this content.\nNo metrics data to plot.\nThe attempt to load metrics for this article has failed.\nThe attempt to plot a graph for these metrics has failed.\nLinearized forward and inverse problems of the resonant ultrasound spectroscopy for the evaluation of thin surface layers\n2. N. Nakamura, H. Ogi, H. Nitta, H. Tanei, M. Fujii, T. Yasui, and M. Hirao, “Study of elastic anisotropy of Cu thin films by resonant-ultrasound spectroscopy coupled with laser-Doppler interferometry and pump-probe photoacoustics,” Jpn. J. Appl. Phys., Part 1 45, 4580–4584 (2006).\n3. A. Bennis, A. M. Lomonosov, Z. H. Shen, and P. Hess, “Laser based measurement of elastic and mechanical properties of layered polycrystalline silicon structures with projection masks,” Appl. Phys. Lett. 88, 101915 (2006).\n4. C. Glorieux, K. Van De Rostyne, J. D. Beers, W. Gao, S. Petillion, N. Van Riet, K. A. Nelson, J. F. Allard, V. E. Gusev, W. Lauriks, and J. Thoen, “Acoustic waves at interfaces studied by laser ultrasonics,” Rev. Sci. Instrum. 74, 465–469 (2002).\n5. X. Jiang, J. Philip, W. J. Zhang, P. Hess, and S. Matsumoto, “Hardness and Young’s modulus of high-quality cubic boron nitride films grown by chemical vapor deposition,” J. Appl. Phys. 93, 1515–1519 (2003).\n7. A. Migliori and J. L. Sarrao, Resonant Ultrasound Spectroscopy: Applications to Physics, Materials Measurements, and Non-Destructive Evaluation (Wiley, New York, 1997), Chap. 8, pp. 119–136\n9. H. Ogi, K. Sato, T. Asada, and M. Hirao, “Complete mode identification for resonance ultrasound spectroscopy,” J. Acoust. Soc. Am. 112, 2553–2557 (2002).\n10. H. Ogi, P. Heyliger, H. Ledbetter, and S. Kim, “Mode-selective resonance ultrasound spectroscopy of a layered parallelepiped,” J. Acoust. Soc. Am. 108, 2829–2834 (2000).\n11. H. Ogi, N. Nakamura, H. Tanei, M. Hirao, R. Ikeda, and M. Takemoto, “Off-diagonal elastic constant and sp2-bonded graphitic grain boundary in nanocrystalline diamond thin films,” Appl. Phys. Lett. 86, 231904 (2005).\n12. N. Nakamura, H. Ogi, and M. Hirao, “Resonance ultrasound spectroscopy with laser-Doppler interferometry for studying elastic properties of thin films,” Ultrasonics 42, 491–494 (2004).\n13. N. Nakamura, H. Ogi, M. Hirao, and T. Ono, “Determination of anisotropic elastic constants of superlattice thin films by resonant-ultrasound spectroscopy,” J. Appl. Phys. 97, 013532 (2005).\n14. N. Nakamura, H. Ogi, and M. Hirao, “Elastic constants of chemical-vapor-deposition diamond thin films: Resonance ultrasound spectroscopy with laser-Doppler interferometry,” Acta Mater. 52, 765–771 (2004).\n16. J. H. So, J. R. Gladden, Y. H. Hu, J. D. Maynard, and Q. Li, “Measurements of elastic constants in thin films of colossal magnetoresistance material,” Phys. Rev. Lett. 90, 036103 (2003).\n17. H. Seiner, M. Růžek, P. Sedlák, L. Bicanová, and M. Landa, “Resonant ultrasound spectroscopy for investigation of thin surface coatings,” WIT Trans. Eng. Sci. 64, 237–248 (2009).\n18. J. Plesek, R. Kolman, and M. Landa, “Using finite element method for the determination of elastic moduli by resonant ultrasound spectroscopy,” J. Acoust. Soc. Am. 116, 282–287 (2004).\n20. W. M. Visscher, A. Migliori, T. M. Bell, and R. A. Reinert, “On the normal modes of free vibration of inhomogeneous and anisotropic elastic objects,” J. Acoust. Soc. Am. 90, 2154–2162 (1991).\n21. M. J. P. Musgrave, Crystal Acoustics (Holden Day, San Francisco, 1970), p.\n22. pmd, Version f77.10 (Vamet/Institute of Thermomechanics, 2010).\n23. M. Landa, P. Sedlák, H. Seiner, L. Heller, L. Bicanová, P. Šittner, and V. Novák, “Modal resonant ultrasound spectroscopy for ferroelastics,” Appl. Phys. A.: Mater. Sci. Process. 96, 557–567 (2009).\n24. H. Seiner, L. Bodnárová, P. Sedlák, M. Janeček, O. Srba, R. Král, and M. Landa, “Application of ultrasonic methods to determine elastic anisotropy of polycrystalline copper processed by equal-channel angular pressing,” Acta Mater. 58, 235–247 (2010).\n25. P. Sedlák, M. Landa, H. Seiner, L. Bicanová, and L. Heller, “Non-contact resonant ultrasound spectroscopy for elastic constants measurement,” in International Symposium on Laser Ultrasonics: Science, Technology and Applications 1, August 16–18, 2008, Montreal, Canada, NDT Database J. available at www.NDT.net (Last viewed November 11, 2010), Article No. 34, pp. 1–6.\n26.To ensure the same experimental conditions for the measurements before and after the deposition, the experiments were performed in a temperature-controlled chamber.\n27. R. M. Jones, Mechanics of Composite Materials (McGraw-Hill, New York, 1975), Chap. 2, pp. 31–84\n28. M. Veidt and W. Sachse, “Ultrasonic point-source/point-receiver measurements in thin specimens,” J. Acoust. Soc. Am. 96, 2318–2326 (1994).\nArticle metrics loading...\nFull text loading...\nMost read this month", "domain": "chemistry", "round": 3} +{"url": "https://cache.kzoo.edu/handle/10920/22659", "date": "2019-07-21T13:30:05Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-30/segments/1563195527000.10/warc/CC-MAIN-20190721123414-20190721145414-00280.warc.gz", "language_score": 0.9425864219665527, "token_count": 273, "dump": "CC-MAIN-2019-30", "global_id": "webtext-fineweb__CC-MAIN-2019-30__0__82371707", "lang": "en", "text": "An In vivo Study of the Role of Opiates in Schizoprenia. 3H-Spiroperidol Binding\nMetadataShow full item record\nSince the 1950's, the development of antipsychotic drugs has lead to several physical models for schizophrenia. The preferred model is the Dopamine hypothesis, which relates schizophrenia to a malfunction of the DA-ergic system. This hypothesis arose from strong correlations between the ability of the drugs to specifically block DA receptors and the therapeutic effects of the drug. Recently, research has indicated that schizophrenia maybe influenced by the opiate peptides in the CNS. One way to study the role of opiate peptides in schizophrenia is to observe their effects-on the--DA receptors. 3H-spiroperidol, an antipsychotic drug that specifically blocks DA receptors, was used to study the effects of the opiate peptides on the DA receptors. The effects of the peptides were observed through changes in 3H-spiroperidol binding. When opiate peptides, which were known to be psychoactive when administered peripherally, were injected into rats before an injection of the tritiated label, the amount of label bound to its DA receptors in several different brain areas increased. This indicates that opiate peptides may play a role in schizophrenia through interaction with the DA receptors.", "domain": "chemistry", "round": 3} +{"url": "http://nomadlab.cn/product/en/productshow_injection.asp?id=40", "date": "2024-02-28T13:53:41Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707947474715.58/warc/CC-MAIN-20240228112121-20240228142121-00770.warc.gz", "language_score": 0.9355648159980774, "token_count": 1662, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__178374194", "lang": "en", "text": "Package : 10ml vial contains 300mg/ml\nSubstance : Nandrolone decanoate\nProfile : NomadLab® Nandrolone decanoate\nAlthough nandrolone decanoate is still contained in many generic compounds and is the most widespread and most commonly used injectable steroid.\nDeca's large popularity can be attributed to its numerous possible applications and, for its mostly positive results. Its main characteristic is clearly defined on the package insert by Organon GmbH Company: \"The distinct anabolic effect of nandrolone decanoate is mirrorred in the positive nitrogen balance.\" Nitrogen, in bonded form is part of protein. Nandrolone decanoate causes the muscle cell to store more nitrogen than it releases so that a positive nitrogen balance is achieved. A positive nitrogen balance is synonymous with muscle growth since the muscle cell, in this phase, assimilates (accumulates) a larger amount of protein than usual. The same manufacturer, however, points out on the package insert that a positive nitrogen balance and the protein building effect that accompany it will occur only if enough calories and proteins are supplied. One should know this; otherwise, satisfying results with Deca Durabolin cannot be obtained. The highly anabolic effect of nandrolone decanoate is linked to a moderately androgenic component, so that a good gain in muscle mass and strength is obtained. At the same time, most athletes notice considerable water retention which, no doubt, is not as distinct as that with injectable testosterones but which in high doses can also cause a smooth and watery appearance. Since nandrolone decanoate also stores more water in the connective tissues, it can temporarily ease or even cure existing pain in joints. This is especially good for those athletes who complain about pain in the shoulder, elbow, and knee; they can often enjoy pain-free workouts during treatment while using nandrolone decanoate. Another reason for this is that it blocks the cortisone receptors. thus allowing less cortisone to reach the muscle cells and the connective tissue cells. Athletes use Deca, depending on their needs, for muscle buildup and in preparation for a competition.\nNandrolone decanoate is suitable, even above average, to develop muscle mass since it promotes the protein synthesis and simultaneously leads to water retention. The optimal dose for this purpose lies between 200 and 600 mg/week. Scientific research has shown that best results can be obtained by the intake of 2 mg/pound body weight. Those who take a dose of less than 200 mg/week will usually feel only a very light anabolic effect which, however, increases with a higher dosage. The anabolic and consequent buildup effect of nandrolone decanoate, up to a certain degree, depends on the dosage. In the range of approx. 200 to 600 mg/week, the anabolic effect increases almost proportionately to the dosage increase. If more than 600 mg/week are administered, the relationship of the positive to the negative effects shifts in favor of the latter. In addition, at a dosage level above 600 mg/week, the anabolic effect no longer increases proportionately to the dosage increase, so that 1000 mg/week do not guarantee significantly better results than 600 mg/week. Most male athletes experience good results by taking 400 mg/week. Steroid novices usually need only 200 mg/week. nandrolone decanoate works very well for muscle buildup when combined with Dianabol (D-bol) and Testoviron Depot. The famous Dianabol (D-bol)/Deca stack results in a fast and strong gain in muscle mass. Most athletes usually take 15-40 mg Dianabol (D-bol)/day and 200-400 mg Deca/week. Even faster results can be achieved with 400 mg Deca/week and 500 mg Sustanon/week. Athletes report an enormous gain in strength and muscle mass when taking 400 mg Deca/week, 500 mg Sustanon/week, and 30 mg Dianabol (D-bol)/day. Deca is a good basic steroid which, for muscle buildup, can be combined with many other steroids.\nAlthough Deca is not an optimal steroid when preparing for a competition, many athletes also achieve good results during this phase. Since nandrolone decanoate is a long-term anabolic, there is risk that with a higher dosage, the competing athlete will retain too much water. A conversion into estrogen, that means an aromatizing process, is possible with nandrolone decanoate but usually occurs only at a dose of 400 mg/week. During competitions with doping tests Deca must not be taken since the metabolites in the body can be proven in a urine analysis up to 18 months later. Those who do not fear testing can use Deca as a high-anabolic basic compound in a dosage of 400 mg/week. The androgens contained in 400 mg/week also help to accelerate the body's regeneration. The risk of potential water retention and aromatizing to estrogen can be successfully prevented by combining the use of Proviron with Nolvadex. A preparatory stack often observed in competing athletes includes 400 mg/week nandrolone decanoate, 50 mg/day Winstrol, 228 mg/week Parabolan, and 25 mg/day Anavar.\nAlthough the side effects with nandrolone decanoate are relatively low with dosages of 400 mg/week, androgenic-caused side effects can occur. Most problems manifest themselves in high blood pressure and a prolonged time for blood clotting, which can cause frequent nasal bleeding and prolonged bleeding of cuts, as well as increased production of the sebaceous gland and occasional acne. Some athletes also report headaches and sexual overstimulation. When very high dosages are taken over a prolonged period, spermatogencsis can be inhibited in men, i.e the testes produce less testosterone. The reason is that nandrolone decanoate, like almost all steroids, inhibits the release of gonadotropin from the hypophysis.\nWomen with a dosage of up to 100 mg/week usually experience no major problems with nandrolone decanoate. At higher dosages androgenic-caused virilization symptoms can occur, including deep voice (irreversible), increased growth of body hair, acne, increased libido, and possibly clitorishypertrophy. Since most female athletes get on well with nandrolone decanoate a dose of Deca 50 mg+/week is usually combined with Anavar 10 mg+/day. Both compounds, when taken in a low dosage, are only slightly androgenic so that masculinizing side effects only rarely occur. Deca, through its increased protein synthesis, also leads to a net muscle gain and Anavar, based on the increased phosphocreatine synthesis, leads to a measurable strength gain with very low water retention. Other variations of administration used by female athletes are nandrolone decanoate and Winstrol tablets, as well as nandrolone decanoate and Primobolan S-tablets. Since nandrolone decanoate has no negative effects on the liver it can even be used by persons with liver diseases. Exams have shown that a combined application of Dianabol / nandrolone decanoate increases the liver £¦#118alues which, however, return to normal upon discontinuance of the 17-alpha alkylated Dianabol and continued administration of nandrolone decanoate. Even a treatment period with nandrolone decanoate over several years could not reveal damage to the liver. For this reason nandrolone decanoate combines well with Andriol (240-280 mg/day) since Andriol is not broken down through the liver and thus the liver function is not influenced either. Older and more cautious steroid users, in particular, like this combination.", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/tmed1-antibody-ab230310.html", "date": "2020-10-20T21:06:00Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-45/segments/1603107874135.2/warc/CC-MAIN-20201020192039-20201020222039-00677.warc.gz", "language_score": 0.66279536485672, "token_count": 382, "dump": "CC-MAIN-2020-45", "global_id": "webtext-fineweb__CC-MAIN-2020-45__0__140441325", "lang": "en", "text": "Key features and details\n- Rabbit polyclonal to TMED1\n- Suitable for: IHC-P\n- Reacts with: Human\n- Isotype: IgG\nProduct nameAnti-TMED1 antibody\nSee all TMED1 primary antibodies\nDescriptionRabbit polyclonal to TMED1\nTested applicationsSuitable for: IHC-Pmore details\nSpecies reactivityReacts with: Human\nPredicted to work with: Mouse, Rat, Cow, Orangutan\n- IHC-P: Human adrenal gland and pancreatic tissues.\nStorage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.\nStorage bufferpH: 7.30\nPreservative: 0.02% Sodium azide\nConstituents: PBS, 50% Glycerol (glycerin, glycerine)\nConcentration information loading...\nPurityImmunogen affinity purified\nOur Abpromise guarantee covers the use of ab230310 in the following tested applications.\n|IHC-P||1/20 - 1/200.|\nFunctionPotential role in protein trafficking.\nTissue specificityWidely expressed.\nSequence similaritiesBelongs to the EMP24/GP25L family.\nContains 1 GOLD domain.\nCellular localizationCell membrane.\n- Information by UniProt\n- IL1RL1 binding protein antibody\n- IL1RL1L antibody\n- IL1RL1LG antibody\nTo our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.\nab230310 has not yet been referenced specifically in any publications.", "domain": "chemistry", "round": 3} +{"url": "https://www.theheraldtimes.com/be-aware-of-the-dangers-of-carbon-monoxide-gas/features/", "date": "2020-03-29T05:50:05Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-16/segments/1585370493818.32/warc/CC-MAIN-20200329045008-20200329075008-00056.warc.gz", "language_score": 0.9329789876937866, "token_count": 533, "dump": "CC-MAIN-2020-16", "global_id": "webtext-fineweb__CC-MAIN-2020-16__0__204447989", "lang": "en", "text": "RBC I Carbon monoxide is an odorless, tasteless and poisonous gas that is given off by the insufficient burning of natural gas and other substances containing carbon. It can be generated from heating systems that use natural gas, as well as gasoline-powered vehicles, charcoal grills or any device that burns gasoline, oil, wood, kerosene or charcoal. The danger in exposure to carbon monoxide is the effect on the oxygen levels in the body.\nCarbon monoxide displaces the oxygen in blood and deprives vital organs like the heart and brain of it. Prevention is the key to keeping you and your family safe from carbon monoxide exposure.\nTo avoid carbon monoxide exposure, choose and install appliances that are properly vented. Most new appliances are designed to be carbon monoxide safe, but they have to be installed correctly. If you are a do-it-yourselfer, make sure these appliances are properly vented to the outside. If someone else is installing them, make sure they are certified to do so. As for existing appliances that burn natural gas or any other carbon monoxide producing material, make sure they are serviced regularly and operating correctly.\nThere are few things regarding carbon monoxide that most of us have done that we shouldn’t. Never let your car idle in the garage, even with the garage door open. Carbon monoxide can build up quickly, and if your garage is connected to your home, the fumes will also invade your living area. Never use a gas oven to heat your home. Never run a kerosene space heater in a non-ventilated room. Finally, never ignore the symptoms of carbon monoxide poisoning.\nThe symptoms of carbon monoxide poisoning depend on the amount of exposure. Low levels of exposure may cause a mild headache or mild nausea. Moderate exposure can cause dizziness, headache, nausea and light headedness. High levels of exposure can be fatal within minutes. The most important thing to do for someone who has been exposed to carbon monoxide is to get them fresh air, preferably outside. The next thing to do is to call 911 for assistance.\nCarbon monoxide detectors are available and can be installed as easily as a smoke detector. However, having one or more of these in your home is not an excuse for failing to properly maintain your carbon monoxide producing appliances.\nThere are many things that will do us or our family harm if left unchecked. Carbon monoxide is one of them. However, with proper maintenance of appliances, installation of carbon monoxide detectors and common sense, we can keep ourselves and the ones we love safe.", "domain": "chemistry", "round": 3} +{"url": "https://www.scientific.net/KEM.484.107", "date": "2017-09-26T19:50:31Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-39/segments/1505818696681.94/warc/CC-MAIN-20170926193955-20170926213955-00287.warc.gz", "language_score": 0.8872203826904297, "token_count": 288, "dump": "CC-MAIN-2017-39", "global_id": "webtext-fineweb__CC-MAIN-2017-39__0__146165427", "lang": "en", "text": "Grain Size Effect in the Electrical Properties of Nanostructured Functional Oxides through Pressure Modification of the Spark Plasma Sintering Method\nThrough the use of a high-pressure modification of the spark plasma sintering method, it was possible to consolidate functional oxides (yttria- stabilized zirconia and doped ceria) to high densities and retain a grain size of < 20 nm. The role of the pressure on densification and on the grain size of the sintered samples was demonstrated. The pressure had a marked effect on density at relatively low temperature but an insignificant effect at relatively high temperature. It was found that when prepared with such small grain sizes, these oxides conduct protonically even at temperatures as low as room temperature. The dependence of the protonic conductivity is stronger dependence on grain size than what can be anticipated from a geometric consideration based on an increase in grain boundary area. This observation strongly suggests that factors other than an increase in grain boundary area play a role, a consideration that is being further investigated.\nTakashi Goto, Yi-Bing Cheng and Takashi Akatsu\nD.V. Quach et al., \"Grain Size Effect in the Electrical Properties of Nanostructured Functional Oxides through Pressure Modification of the Spark Plasma Sintering Method\", Key Engineering Materials, Vol. 484, pp. 107-116, 2011", "domain": "chemistry", "round": 3} +{"url": "https://pure.hud.ac.uk/en/publications/monoclonal-antibodies-against-babesia-caballi-and-babesia-equi-an", "date": "2023-12-02T11:09:26Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100399.81/warc/CC-MAIN-20231202105028-20231202135028-00591.warc.gz", "language_score": 0.9185594916343689, "token_count": 250, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__64010629", "lang": "en", "text": "The production of monoclonal antibodies to the bloodstages of the haemoprotozoan parasites Babesia caballi and Babesia equi and the characterization of their corresponding antigens are described. Species specific and immunogenic proteins of both parasites were identified using SDS-PAGE, Western blotting and ELISA. These proteins were then electroeluted from SDS-PAGE gels and used to immunize BALB/c mice for hybridoma production. One monoclonal antibody (Mab), designated BC22.214.171.124 (BC5), recognized a 70 kDa protein of B. caballi as demonstrated by Western blotting under reducing conditions. Another Mab, BE1.24/2.95 (BEI), recognized a 34 kDa protein of B. equi. Both Mabs reacted specifically in indirect ELISA when isolated whole merozoites were used as antigen. Preliminary studies using the two Mabs in a competitive ELISA (cELISA) suggest that the cELISA for the detection of B. caballi infection is more sensitive than the commonly used complement fixation test but that refinement is necessary for the B. equi system.", "domain": "chemistry", "round": 3} +{"url": "https://www.frontiersin.org/articles/10.3389/fphy.2022.936385/abstract", "date": "2022-06-25T12:07:10Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-27/segments/1656103034930.3/warc/CC-MAIN-20220625095705-20220625125705-00132.warc.gz", "language_score": 0.8676550984382629, "token_count": 400, "dump": "CC-MAIN-2022-27", "global_id": "webtext-fineweb__CC-MAIN-2022-27__0__166844499", "lang": "en", "text": "ORIGINAL RESEARCH article\nSelf-assembly in Mixtures of Charged Lobed Particles\n- 1University of New Hampshire, United States\n- 2Chemical Engineering, University of New Hampshire, United States\nWe report coarse-grained Langevin dynamics simulations of homogeneous mixtures of lobed colloidal particles with opposite charges. We show that dumbbell, trigonal planar, tetrahedral, square planar, trigonal bipyramidal, and octahedral shaped particles form distinct self-assemblies including chains, sheets, crystalline, and spherical structures. The dumbbell and square planar particles predominantly form chains and sheets while other particles form network-like self-assembled morphologies. At higher temperatures and lower charges, non-planar particles form three-dimensional aggregates. We further report on packing arrangements of particles which lead to differences in porosities within self-assembled morphologies. Our results show that the trigonal planar particles form larger porous structures. The self-assembled structures that we report are potentially useful in designing porous biomaterials for biomedical applications.\nKeywords: self-assembly, charged lobed particles, Particle mixtures, Porous structures, long range interactions\nReceived: 05 May 2022;\nAccepted: 17 Jun 2022.\nCopyright: © 2022 Srivastava, Rocha and Vashisth. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.\n* Correspondence: Prof. Harish Vashisth, University of New Hampshire, Chemical Engineering, Durham, 03824, NH, United States", "domain": "chemistry", "round": 3} +{"url": "https://geosyntec.com/consultants/publications/item/5259-per-and-poly-fluorinated-alkyl-substances-pfas-investigation-and-cleanup", "date": "2022-01-25T20:57:14Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-05/segments/1642320304872.21/warc/CC-MAIN-20220125190255-20220125220255-00575.warc.gz", "language_score": 0.9066463708877563, "token_count": 277, "dump": "CC-MAIN-2022-05", "global_id": "webtext-fineweb__CC-MAIN-2022-05__0__195274137", "lang": "en", "text": "Co-presenters included Dr. Jennifer Field from Oregon State University and Dr. Christopher Higgins of Colorado School of Mines.\nThe webinar was attended more than 200 people and answered the following questions:\n- What are per- and polyfluoroalkyl substances (PFAS)?\n- What are aqueous film forming foams (AFFF?)\n- What industrial sectors manufacture materials with PFAS?\n- Which environmental media should be sampled?\n- How do PFAS transport in the environment?\n- What is the fate of PFAS in the environment?\n- What remedial tools are available or effective for PFAS?\n- What are the human exposure pathways and health effects?\n- What are the current regulatory issues?\nNEWMOA is an interstate association that has a membership composed of the hazardous waste, solid waste, waste site cleanup, and pollution prevention programs in the northeast states.\n- Geosyntec Authors: Rula Deeb, Jason M. Conder\n- All Authors: Rula Deeb, Jason M. Conder, Jennifer Field, Dr. Christopher Higgins\n- Title: PFAS Webinar for NEWMOA\n- Event or Publication: Event\n- Practice Areas: Contaminated Sites\n- Citation: September 21, 2016\n- Date: 2016\n- Location: Online", "domain": "chemistry", "round": 3} +{"url": "https://www.mdpi.com/2223-7747/9/1/18", "date": "2020-01-18T19:39:32Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-05/segments/1579250593937.27/warc/CC-MAIN-20200118193018-20200118221018-00240.warc.gz", "language_score": 0.8060191869735718, "token_count": 476, "dump": "CC-MAIN-2020-05", "global_id": "webtext-fineweb__CC-MAIN-2020-05__0__64260619", "lang": "en", "text": "Manganese Homeostasis in Cyanobacteria\nBiochemie der Pflanzen, Heinrich-Heine-Universität Düsseldorf, 40225 Düsseldorf, Germany\nPlants 2020, 9(1), 18; https://doi.org/10.3390/plants9010018\nReceived: 9 December 2019 / Revised: 19 December 2019 / Accepted: 20 December 2019 / Published: 23 December 2019\n(This article belongs to the Special Issue Manganese Homeostasis in Plant)\nManganese (Mn) is essential for life on earth. As a catalyst of the water oxidation reaction within photosystem II, the trace metal is responsible for the evolution of virtually all oxygen in the earth’s atmosphere. Mn acts furthermore as an activator or cofactor of numerous enzymes involved in reactive oxygen species scavenging or central and secondary metabolism. While the sufficient supply of oxygenic photosynthetic organisms with Mn is obvious for maintaining photosynthetic activity, the avoidance of cellular Mn overload is also critical. In this review, current knowledge about the Mn homeostasis network in the model cyanobacterium Synechocystis sp. PCC 6803 is presented, including transporters and regulators. View Full-Text\nKeywords: manganese; cyanobacteria; homeostasis; transporter; photosystem II; Mn cluster; regulation►▼ Show Figures\nThis is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited\nMDPI and ACS Style\nEisenhut, M. Manganese Homeostasis in Cyanobacteria. Plants 2020, 9, 18.\nAMA StyleShow more citation formats Show less citations formats\nEisenhut M. Manganese Homeostasis in Cyanobacteria. Plants. 2020; 9(1):18.Chicago/Turabian Style\nEisenhut, Marion. 2020. \"Manganese Homeostasis in Cyanobacteria.\" Plants 9, no. 1: 18.\nFind Other Styles\nNote that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.", "domain": "chemistry", "round": 3} +{"url": "https://www.calpaininhibitor.com/2018/07/13/6854/", "date": "2022-05-29T02:30:19Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-21/segments/1652663035797.93/warc/CC-MAIN-20220529011010-20220529041010-00558.warc.gz", "language_score": 0.9192111492156982, "token_count": 769, "dump": "CC-MAIN-2022-21", "global_id": "webtext-fineweb__CC-MAIN-2022-21__0__25955385", "lang": "en", "text": "Production in any medium,supplied the original operate is effectively credited. The Creative Commons Public Domain Dedication waiver (http:creativecommons.orgpublicdomainzero.) applies to the information produced out there within this write-up,unless otherwise stated.Letzel et al. BMC Genomics ,: biomedcentralPage ofleader sequence and also a Cterminal core sequence,encoded by a single gene is translated,the leader sequence is removed by a series of transporters,peptidases or a mixture of each,as well as the remaining active peptide moiety is further processed by other enzymes,normally encoded by genes within close proximity towards the precursor gene . The genetic basis for the production of lots of RiPP classes is nicely understood,and in most situations,gene content and structure is conserved amongst unique arms of your bacterial phylogenetic tree. As such,comparison of effectively characterized Lysipressin biosynthetic genes or gene clusters against new genome sequences can determine putative RiPPs and in some circumstances,even the structure of your target metabolite is often predicted . This “genome mining” approach makes it possible for for the discovery of potentially novel natural goods in a entirely culture independent style,together with the potential to decrease the rediscovery rate of identified molecules. Moreover,genome mining has expanded the definition of exactly what constitutes a secondary metabolite producer and has revealed that the biosynthetic possible of lots of microorganisms has been widely underestimated . Amongst these newly identified producers lie the anaerobic bacteria,a group that had been believed to become incapable of creating secondary metabolites,as life without oxygen was presumed to not deliver the expected power for the complicated biosynthesis of antibiotics . These “neglected” bacteria include things like these which might be known to make very toxic peptides (botulinum toxin,tetanus toxin),and much more not too long ago quite a few species have already been identified as the supply of novel all-natural products . An extensive investigation of genomes of anaerobic bacteria for the presence of polyketide synthase (PKS) or nonribosomal peptide synthetase (NRPS) encoding genes revealed a substantially larger PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/21120998 potential than previously suspected and lots of of these PKS or NRPS loci appeared to be novel,with restricted homology to previously characterized gene clusters . Additionally,it showed that specific genera have a predisposition towards increased secondary metabolite possible (for instance members of your phyla Proteobacteria and Firmicutes) and that the all-natural habitat of your organisms appears to play a crucial role isolates from environmental strains (soil,mud) often include as much as three times far more genes for secondary metabolite biosynthesis than all other habitats combined. In unique,the clostridia had been shown to become a possible treasure trove of novel secondary metabolites,which the isolation with the novel antibiotics closthioamide and clostrubin have not too long ago confirmed . Despite the recent investigation of anaerobes for their possible to generate polyketide or nonribosomal peptide metabolites ,tiny is identified about their capability to generate RiPPs. As anaerobes have been shown to possess a wealth of novel biosynthetic gene clusters,this suggests that there’s also the prospective to determine novel RiPP genetic lociamongst these organisms. This could,in turn,lead to the discovery of novel antimicrobial compounds to treat multidrug resistant infections. Here we present an indepth investigation of RiPPencoding genes within the genomes of anaerobic bacteria. As the no.", "domain": "chemistry", "round": 3} +{"url": "https://vip-photoshop.ru/dating-old-20022.html", "date": "2019-08-18T18:55:58Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-35/segments/1566027313996.39/warc/CC-MAIN-20190818185421-20190818211421-00089.warc.gz", "language_score": 0.9564303159713745, "token_count": 600, "dump": "CC-MAIN-2019-35", "global_id": "webtext-fineweb__CC-MAIN-2019-35__0__43757679", "lang": "en", "text": "Over time, however, discrepancies began to appear between the known chronology for the oldest Egyptian dynasties and the radiocarbon dates of Egyptian artefacts.Neither the pre-existing Egyptian chronology nor the new radiocarbon dating method could be assumed to be accurate, but a third possibility was that the In the 1960s, Hans Suess was able to use the tree-ring sequence to show that the dates derived from radiocarbon were consistent with the dates assigned by Egyptologists.Wir bieten den europäischen Singles die online Kontaktanzeigen Frauen aus Russland und Osteuropa. I am a woman, who is traditional, loving, moral, caring, trustworthy, social, loyal, respectful, dependable, patient, family, and community oriented, and orderly. more of knuckmyheart i'm a lovely cute and reasonable self made, that loves how to care about a man who, unless if and only if he knows is responsibility how to care about her own woman such a man dese... Additional complications come from the burning of fossil fuels such as coal and oil, and from the above-ground nuclear tests done in the 1950s and 1960s.Because the time it takes to convert biological materials to fossil fuels is substantially longer than the time it takes for its in the atmosphere, which attained a maximum in 1963 of almost twice what it had been before the testing began.\nthe average or expected time a given atom will survive before undergoing radioactive decay. The calculations involve several steps and include an intermediate value called the \"radiocarbon age\", which is the age in \"radiocarbon years\" of the sample: an age quoted in radiocarbon years means that no calibration curve has been used − the calculations for radiocarbon years assume that the , which for more than a decade after Libby's initial work was thought to be 5,568 years.A correction for the half-life is incorporated into calibration curves, so even though radiocarbon ages are calculated using a half-life value that is known to be incorrect, the final reported calibrated date, in calendar years, is accurate.When a date is quoted, the reader should be aware that if it is an uncalibrated date (a term used for dates given in radiocarbon years) it may differ substantially from the best estimate of the actual calendar date, both because it uses the wrong value for the half-life of and each component is also referred to individually as a carbon exchange reservoir.Measurement of radiocarbon was originally done by beta-counting devices, which counted the amount of beta radiation emitted by decaying atoms in the sample and not just the few that happen to decay during the measurements; it can therefore be used with much smaller samples (as small as individual plant seeds), and gives results much more quickly.The development of radiocarbon dating has had a profound impact on archaeology.", "domain": "chemistry", "round": 3} +{"url": "https://www.experimentalaircraft.info/homebuilt-aircraft/liqui-moly-aero-oil-additives.php", "date": "2022-12-08T05:27:13Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-49/segments/1669446711278.74/warc/CC-MAIN-20221208050236-20221208080236-00816.warc.gz", "language_score": 0.9355282187461853, "token_count": 759, "dump": "CC-MAIN-2022-49", "global_id": "webtext-fineweb__CC-MAIN-2022-49__0__240205588", "lang": "en", "text": "With the correct oil friction losses in an engine are reduced to a minimum. This is done by taking into consideration circumstances as engine usage, ambient temperature, time of year and climate, location and engine design. The engine manufacturer usually recommends a certain type of oil to use with regard to different circumstances.\nLubricating oil plays an important part in the life of the engine and during maintenance it will be replaced, on certified aircraft the pilot can only replenish it.\nEngine oil contains additives known as friction modifiers/reducers and anti wear additives which are soluble and are used in the lubrication industry for many years now. On this page we are going to emphasize the oil additives from Liqui Moly Aero which are purposely manufactured for the Rotax line of engines.\nFor every hour you fly, you pay with a tiny piece of the engine, this is because of friction and wear of all moving metal parts. The result of this can be seen from accumulated metals abrasion in the oil during analysis. With LIQUI MOLY Oil Additives like 'AERO Fly Safe Engine Protector' or 'AERO Fly Safe Engine & Gearbox Protector' this wear can be reduced significantly.\nIn spite of all efforts to produce smooth metal surfaces they remain, when viewed under a microscope, rough and uneven (see image 1). These irregularities are compensated for with the application of solid lubricants such as molybdenum disulfide (MoS2) or micro ceramics (image 2).\nSurface treatment considerably reduces frictional resistance and wear: chemical agents, or so-called friction modifiers chemically bond with the metallic surface and smooth the high points of metal pairing surfaces, thereby eliminating damage (image 3).\nMore information about additives in engine oil can be found in our article on friction and wear and here: https://en.wikipedia.org/wiki/Molybdenum_disulfide.\nSpecially developed by LIQUI MOLY for 4-stroke ROTAX aircraft engines with step-down transmission (912,914,915 series). Also outstandingly suitable for JET FUEL diesel aircraft engines. This oil improver is suitable for engines with or without a slip clutch, for adding to the motor oil.\nThe 80 and 100 HP engines in ultralight, LSA and experimental aircraft often have to work in the most difficult conditions such as: cold starting, full power during takeoff usually at the weight limit, high outside temperatures, long ascents on full power, shock cooling when descending.\nVery often the aviation and light aircraft engines can go weeks without ever being used, winter time being an example.\nUnder these extremely tough operating conditions the oil plays a critical role in the operational reliability and long life of the engine.\nProtects against internal corrosion even if the engine is not used for long periods. Specially developed for 4-stroke ultralight engines with or without a slip clutch and features high-tech ceramic wear protection that prevents direct metal-on-metal contact.\nIt reduces wear and friction in engine and gearbox and is stable even under high thermal and dynamic permanent loads. Resists extremely high and low temperatures and saves fuel.\nProlongs engine service life and prevents internal corrosion, improves smooth operation and compression, higher performance gain due to reduced internal friction.\nThe product has emergency running properties and one tube is sufficient for up to 4 liters. The content of this tube has been geared to and is sufficient for adding in oil changes of the ROTAX 912 engine. Read more about this product here.\nText and images used with permission.\nFor detailed description see the: Liqui Moly Aero web site.Written by EAI.", "domain": "chemistry", "round": 3} +{"url": "https://pubmed.ncbi.nlm.nih.gov/2306270/?dopt=Abstract", "date": "2021-05-09T23:30:07Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-21/segments/1620243989018.90/warc/CC-MAIN-20210509213453-20210510003453-00128.warc.gz", "language_score": 0.8937734365463257, "token_count": 263, "dump": "CC-MAIN-2021-21", "global_id": "webtext-fineweb__CC-MAIN-2021-21__0__162297953", "lang": "en", "text": "Several monoclonal antibodies against human liver glutathione S-transferase mu were developed. One of these monoclonal antibodies, called GST-3H4 was further characterized and used in this study. In hepatic tissue, after immunoblotting, GST-3H4 strains a 27 kDa protein with a pI value of 6.2. GST-3H4 recognizes other human class-mu glutathione S-transferases, but does not detect acidic or basic glutathione S-transferases. By immunodetection with this monoclonal antibody, glutathione S-transferase mu can be demonstrated in human breast, stomach, liver, small and large intestine, mononuclear blood cells, kidney and placenta. A 100% correlation is found in the distribution of glutathione S-transferase mu when different tissues or mononuclear blood cells from the same individuals are investigated. In 62.5% of the mononuclear blood cells from controls, glutathione S-transferase mu is present. In patients with polyposis coli, breast cancer or colon cancer a similar distribution is found. Therefore no important role for glutathione S-transferase mu deficiencies in the aetiology of these diseases is suggested.", "domain": "chemistry", "round": 3} +{"url": "http://psiwood.com/air-quality-testing-patapsco-md-21048.html", "date": "2018-03-18T19:15:27Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-13/segments/1521257645943.23/warc/CC-MAIN-20180318184945-20180318204945-00578.warc.gz", "language_score": 0.9502023458480835, "token_count": 750, "dump": "CC-MAIN-2018-13", "global_id": "webtext-fineweb__CC-MAIN-2018-13__0__110791085", "lang": "en", "text": "Introducing VOC Testing VOCs are offered with a huge variety of items numbering in the hundreds. The VOC screening that we offer targets the precise chemical to end if they’re existent as well as the local area which they’re occupying. In addition, there are several views of the science and healthcare local areas in regards to the quantity of danger postured by various degrees of VOCs. Many people don’t appear to have practically any effect to pretty small levels of VOCs, though other people are pretty delicate. We’ve constructed industrial and experienced testing equipment with techniques that anyone can use. Moldlabs volatile organic chemicals testing system is the greatest and most basic test it can be done to decide on. Instead to screening, the First transfer is always to conduct an evaluation of your house for the natural deposits of VOC. A technician walks through the whole building, screening both total oxygens together with some locations of concerns.\nCertified Indoor Air Quality Tests and Laboratory Results\nIf you were to think you might be having health problems brought on by VOC, think about minimizing quantities is most likely to house. If open VOC’s may lessen your individual quality of air, and be damaging to your health. VOCs aren’t toxic in secondary volumes, however over high levels of the duration, direct exposure can provide many health risks which range from basic allergies to some most likely increased threat of particular cancers. Our location as well as in- home laboratory screening providers provide you with the understanding to boost the generation method and get your option to market quickly and financially. This prediction depends upon upon input from the various business to this outcome. Typically, the more pricey nature, the larger the cost. The few different companies who perform these suppliers might be useful in obtaining the products, nonetheless they’ll probably come in regards to interpreting the results. There are numerous various chemical toxic substances present in numerous resources. Reports of animals have exposed that breathing some ranges of VOCs throughout a long time period can enhance the risk of increasing cancer. Some folks begin having symptoms after simply one exposure to high charges of numerous harmful materials.\nBreathing small degrees of VOCs for extended periods may improve some people’s danger of medical problems. Breathing low quantities of VOC for extended intervals can magnify the danger of medical issues. Breathing decreased expenses of VOCs for a very extended period could trigger a raised risk of medical issues. Ventilation and climate control might be used to minimize the experience of VOC in Patapsco MD.\nWe’ve got numerous methods of computing volatile natural substances, in line with the amount of detail you want. You are needed to learn about the VOC requirements for your items and be sure you comply. When you remain in will require of VOC testing, contact the group to extend the outcome you should protect yourself.\nYour certified evaluation business signs up the current presence of devastating VOCs in your house so you may take the techniques needed to produce a wholesome, much safer indoor environment. It is essential that you choose precisely which pollutants take place in water before selecting the plan. Though a few of it is likely to leave while in the environment, there’ll be described as a little portion that’ll soak inside the surface and might attain water sources. Possibly modest degrees of VOCs might be wrong for you along with your household’s health. This is the reason it is suggested to have the quality of air tested for VOC’s in your house or place of business., it is, therefore, essential that you look for VOC.", "domain": "chemistry", "round": 3} +{"url": "https://www.organicfertilizermachinery.com/industry-info/organic-fertilizer-extrusion-granulator-double-roller-extrusion-granulator.html", "date": "2023-06-02T22:09:07Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-23/segments/1685224648858.14/warc/CC-MAIN-20230602204755-20230602234755-00168.warc.gz", "language_score": 0.8944733738899231, "token_count": 374, "dump": "CC-MAIN-2023-23", "global_id": "webtext-fineweb__CC-MAIN-2023-23__0__189216227", "lang": "en", "text": "The double roller granulator\nadopts the dry rolling technology to compress the powdery materials with water content ≤ 15% into flakes or blocks, and then through crushing and screening process, the flake and block materials become granular materials meeting the requirements of use. In the process of rolling, the actual density of materials can be increased by 1.5 ~ 3 times, so as to meet the requirements of certain particle strength.\nThe whole granulation process of the double roller granulator does not need to add any other items. It maintains the high quality of the original products. The granulated particles are packaged and sold in the screened products that meet the requirements of industrial standards. Otherwise, it will be returned to this place for re granulation.\nProduct features of double roller granulator are as follows:\n- 1. The organic fertilizer granulation machine has the advantages of compact structure, convenient maintenance, simple operation, short process flow, low energy consumption, high efficiency and failure rate.\n- 2. Circulation operation to realize continuous production and high output of finished products.\n- 3. The organic fertilizer granulation machine has a wide range of raw materials, and the particle strength can be adjusted freely according to different materials.\n- 4. Direct granulation of dry powder without subsequent drying process is more conducive to the connection and transformation of the existing production process.\n- 5. The particle strength is high, and the increase of bulk specific gravity is more significant than other granulation methods, especially suitable for increasing the bulk specific gravity of products.\n- 6. The material is forced to be compressed by mechanical pressure without any additives, and the purity of the product is guaranteed.\n- 7. The particle strength of the organic fertilizer granulation machine can be adjusted, and the finished product strength can be controlled by adjusting the roller pressure.", "domain": "chemistry", "round": 3} +{"url": "https://www.ars.usda.gov/research/publications/publication/?seqNo115=361757", "date": "2023-12-09T15:52:06Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100912.91/warc/CC-MAIN-20231209134916-20231209164916-00160.warc.gz", "language_score": 0.9485514163970947, "token_count": 461, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__137840741", "lang": "en", "text": "Submitted to: American Society for Microbiology Meeting\nPublication Type: Abstract Only\nPublication Acceptance Date: 2/28/2019\nPublication Date: N/A\nInterpretive Summary: n/a\nTechnical Abstract: Background: It is well established that gut microbiota has the important effects on broiler nutrition, growth and immunological development. Due to the progress in nucleotide sequencing technology and bioinformatic algorithms, broiler cecal bacterial communities have been extensively investigated at the taxonomic levels. However, the functional diversity and metabolic activity of broiler cecal bacterial communities are not fully explored. Carbon is an essential element for bacterial growth. Thus, the patterns of carbon utilization from various carbon sources have been applied to characterize bacterial communities from various environments. One such approach is to use EcoPlates™ to assess physiological profiling at the bacterial community level. In this study, we applied these plates to profile cecal bacterial communities in broiler chickens. Methods: The caeca were aseptically excised from six-week-old broilers. The cecal contents were diluted in phosphate buffered saline, and were delivered in 96-well EcoPlates. The plates were then incubated at 42 oC for 120 hours in an OmniLog system. Responses of the bacterial communities to various carbon sources were measured on formazin production. The Growthcurver and Gompertz packages in R and GraphPad Prism 7 were used for statistical analyses. Results: The sigmoidal growth curves with three phases were observed in all cecal samples. Broiler cecal bacterial communities could not use 11 chemicals for carbon sources; instead, they used pyruvic acid methyl ester, glycogen, glucose-1-phosphate and N-acetyl-D-glucosamine most frequently. Each bacterial community metabolized various numbers of the substrates at different rates among broilers. Conclusion: In summary, the functional profiling of broiler cecal bacterial communities was assessed by carbon sources with EcoPlates. These results provide insight of the potential heterotrophic bacterial community in broiler caeca, and a rationale for further evaluation of this technique to assess microbial community characteristics leading to improving management in poultry production.", "domain": "chemistry", "round": 3} +{"url": "https://www.minds.wisconsin.edu/handle/1793/7198/browse?type=author&value=Laatsch%2C+Bethany", "date": "2023-06-10T15:24:14Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-23/segments/1685224657720.82/warc/CC-MAIN-20230610131939-20230610161939-00479.warc.gz", "language_score": 0.7244566679000854, "token_count": 552, "dump": "CC-MAIN-2023-23", "global_id": "webtext-fineweb__CC-MAIN-2023-23__0__187186271", "lang": "en", "text": "Browsing Student Research Day by Author \"Laatsch, Bethany\"\nNow showing items 1-4 of 4\nExploring the Effects of Monomer and Polymer Cosolutes on the Conformation of Escherichia coli Prolyl-tRNA Synthetase Using Intrinsic Tryptophan Fluorescence Spectroscopy Johnson, Benjamin; Fossum, Carl; Liebau, Jessica; Liew, Aubrey; Laatsch, Bethany; Hati, Sanchita (2021-04)\nHow Does Varying Sizes and Concentrations of Poly(Ethylene Glycol) Affect the Conformation and Function of the Enzyme Escherichia Coli Prolyl-Trna Synthetase? Liebau, Jessica; Laatsch, Bethany; Lowater, Harrison; Hati, Sanchita (2021-04)Poly(ethylene glycol) (PEG) is a biocompatible, hydrophilic, flexible, non-toxic polyether commonly used in proteomics because it is widely regarded to be a biologically inert molecule. This includes PEG2000 (molecular ...\nMolecular Dynamics Simulation Studies to Probe the Impact of Oxidative Stress on the Binding of SARS-CoV-2 Spike Protein to Angiotensin-Converting Enzyme 2 Fossum, Carl; Lowater, Harrison; Narkiewicz-Jodko, Alexander; Laatsch, Bethany; Lonzarich, Leo; Hati, Sanchita; Bhattacharyya, Sudeep (2021-04)The receptor-binding domain (RBD) of the SARS-CoV-2 spike protein as well as the human cell surface receptor angiotensin-converting enzyme II (ACE2) contain several cysteine residues. These cysteine residues exist either in ...\nRole of a Conserved Disulfide on the Interactions Between Severe Acute Respiratory Syndrome Coronavirus 2 and Angiotensin-Converting Enzyme 2 Walk, Gavin; Titera, Noah; Sparks, Hailee; Schierenbeck, Jacqueline; Rocksvold, Alexander; Running-Fischer, Charles; Laatsch, Bethany; Lowater, Harrison; Bhattacharyya, Sudeep (2021-04)Coronaviruses are large, enveloped, positive strand RNA viruses capable of infecting a large array of mammalian and avian species that possess densely glycosylated spike-shaped proteins on their surfaces giving them the ...", "domain": "chemistry", "round": 3} +{"url": "https://www.worldwidewords.org/turnsofphrase/tp-squ1.htm", "date": "2020-08-03T15:01:49Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-34/segments/1596439735812.88/warc/CC-MAIN-20200803140840-20200803170840-00399.warc.gz", "language_score": 0.9602389335632324, "token_count": 269, "dump": "CC-MAIN-2020-34", "global_id": "webtext-fineweb__CC-MAIN-2020-34__0__142983333", "lang": "en", "text": "This substance shows promise for cancer therapy; it is about to begin clinical trials with patients suffering from brain or breast cancers. Squalamine was discovered in 1993 in the stomach and liver of the dogfish, a type of shark. Its name is a compound of amine with squalus, the name of the dogfish genus, which derives from the Latin squalum for a type of fish. The compound is believed to act by preventing blood vessels in the human body from obeying commands from cancer cells to link to them, so starving them of the blood supply that is essential for growth. One of the main hopes for this new drug is that cancers will fail to develop resistance to it because it doesn’t act on the cancer cells themselves, but on the existing blood vessels. Several related types of compound have been discovered recently, including magainins from the African clawed frog, all of which are members of a class of substances called peptidomimetics which mimic the action of peptides in the body to block abnormal or unwanted growth. Many of them, including squalamine, also seem to have antibacterial or antiviral action and a couple have shown promise as treatments for AIDS.\nSearch World Wide Words\nSupport this website!\nDonate via PayPal. Select your currency from the list and click Donate.", "domain": "chemistry", "round": 3} +{"url": "https://www.jointhire.com.sg/job/2342?utm_source=ggjobs", "date": "2023-10-04T16:44:02Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233511386.54/warc/CC-MAIN-20231004152134-20231004182134-00372.warc.gz", "language_score": 0.8781801462173462, "token_count": 364, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__261143118", "lang": "en", "text": "Industry: Chemical / Biochemical / Petrochemical\nSpecialism: Engineering / Technical - ChemicalClosed\nOur client was established in 1997. A wholly owned subsidiary of a major chemical company in Japan. They produce Super-Pure Hydrogen Peroxide and Ammonium Hydroxide for the semiconductor industry.\n- Reports directly to the Production Supervisor.\n- Performs filling of hydrogen peroxide, ammonium hydroxide and mixing and filling of chemical polisher within stipulated targets and acceptable quality levels.\n- Executes all production activities as instructed, such as but not limited to container preparations, inspections, washing, loading and palletizing to and from conveyor, strapping, packaging inspection, shrink wrapping, material receiving and handling, barcode generation and printing.\n- Prescribe to adhere the procedure on QMS, EMS and OHS.\n- Carry out necessary process parameters and record the data on check sheet and ensure that the readings are within prescribe operational range.\n- Able to carry out and use hand held equipment necessary for operation activities.\n- Able to carry out and use NAV operations.\n- Able to carry out simple maintenance work.\n- Able to carry out process and line improvement.\n- Maintains the general upkeep and cleanliness of the production area.\n- Strictly adhere to safety rules and donning of PPE when performing activities.\n- Strictly adhere to standard operating procedure and observing line discipline.\n- Performs any other tasks as instructed by the Superior.\n- At least ITE/Diploma in Chemical/ Science/ Mechanical Engineering or any relevance fields\n- No experience is required\n- Physically fit\n- Able to work in cleanroom environment (uniform provided)\n- Able to use Microsoft Office", "domain": "chemistry", "round": 3} +{"url": "http://www.chem.umn.edu/groups/gagliardi/molcas.html", "date": "2013-05-19T18:33:48Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2013-20/segments/1368697974692/warc/CC-MAIN-20130516095254-00050-ip-10-60-113-184.ec2.internal.warc.gz", "language_score": 0.7223737239837646, "token_count": 408, "dump": "CC-MAIN-2013-20", "global_id": "webtext-fineweb__CC-MAIN-2013-20__0__82977031", "lang": "en", "text": "Molcas: A Quantum Chemistry Software\nMOLCAS is a quantum chemistry software developed by scientists to be used by scientists. The authors have tried in MOLCAS to assemble their collected experience and knowledge in computational quantum chemistry. A number of groups around the world work together in the join project of developing a useful platform to perform quantum chemical calculations:\n|Version 7.6 of Molcas has been released in 2011|\n|The Molcas Network|\nMolcas: Release 7.6. K. Andersson, F. Aquilante, M. Barysz, E. Bednarz, A. Bernhardsson, M. R .A. Blomberg, Y. Carissan, D. L. Cooper, M. Cossi, A. Devarajan, L. De Vico, N. Ferré, M. P. Fülscher, A. Gaenko, L. Gagliardi, G. Ghigo, C. de Graaf, B. A. Hess, D. Hagberg, A. Holt, G. Karlström, J. W. Krogh, R. Lindh, P.-Å. Malmqvist, T. Nakajima, P. Neogrády, J. Olsen, T. B. Pedersen, J. Raab, M. Reiher, B. O. Roos, U. Ryde, B. Schimmelpfennig, M. Schütz, L. Seijo, L. Serrano-Andrés, P. E. M. Siegbahn, J. Stålring, T. Thorsteinsson, V. Veryazov, P.-O. Widmark, and A. Wolf.,\nDepartment of Theoretical Chemistry, Lund University, Sweden (2007).\nExamples of recent applications performed in Minneapolis using the latest tools in MOLCAS:", "domain": "chemistry", "round": 3} +{"url": "https://dl.asminternational.org/technical-books/edited-volume/160/chapter-abstract/3267490/Failure-of-the-Bond-Between-a-Cobalt-Alloy?redirectedFrom=fulltext", "date": "2022-07-04T05:21:04Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-27/segments/1656104354651.73/warc/CC-MAIN-20220704050055-20220704080055-00745.warc.gz", "language_score": 0.9183623790740967, "token_count": 304, "dump": "CC-MAIN-2022-27", "global_id": "webtext-fineweb__CC-MAIN-2022-27__0__93254651", "lang": "en", "text": "Failure of the Bond Between a Cobalt Alloy Prosthetic Casting and a Sintered Porous Coating\nA femoral knee implant was returned to the casting vendor for analysis after exhibiting poor bond strength between the cast substrate and a sintered porous coating. Both the coating and the substrate were manufactured from a cobalt-chromium-molybdenum alloy. Metallographic analysis indicated that a decarburized layer existed on all surfaces of the casting, which prevented bonding during the sintering thermal cycle. Bead-to-bead bonding within the coating appeared sufficient, and no decarburized layer was present on the bead surfaces. It was concluded that the decarburization did not occur during the sintering thermal cycle. It was recommended that the prosthetic manufacturer investigate...\nMark Lisin, Robert R. Peterson, Failure of the Bond Between a Cobalt Alloy Prosthetic Casting and a Sintered Porous Coating, Handbook of Case Histories in Failure Analysis, Vol 1, Edited By Khlefa A. Esaklul, ASM International, 1992, p 449–451, https://doi.org/10.31399/asm.fach.v01.c9001133\nDownload citation file:\nJoin ASM International\nBeing a member of the world’s largest association of materials professionals provides the benefits and resources you need to accomplish your personal and professional goals.", "domain": "chemistry", "round": 3} +{"url": "http://foodmicro2008.org/these-might-match-dimers-from-the-monomer-form-and-non-full-length-forms-with-incomplete-c-termini-due-to-early-translational-termination-or-enzyme-degradation-possibly/", "date": "2022-08-13T10:19:18Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571911.5/warc/CC-MAIN-20220813081639-20220813111639-00708.warc.gz", "language_score": 0.9259210228919983, "token_count": 1501, "dump": "CC-MAIN-2022-33", "global_id": "webtext-fineweb__CC-MAIN-2022-33__0__2533872", "lang": "en", "text": "These might match dimers from the monomer form and non-full-length forms with incomplete C-termini, due to early translational termination or enzyme degradation possibly. recombinant and reactions cloning were performed according to regular protocols. DNA sequences coding for E1 amino a-cid (aa) 192-340 and aa 192-383 had been amplified from pUC19/E1E2-W and pUC18/CE1E2-Z, and cloned into pQE8 between your Examples analyzed on regular reductive SDS-PAGE accompanied by Coomassie Outstanding Blue staining. (A) and (B): appearance and purification of E1Z340 and E1Z262W326N. Street 1: induced TG-1(pQE8) AMG-Tie2-1 as detrimental control; street 2: whole-cell test after induction; street 3: soluble small percentage after sonication; street 4: insoluble small percentage after sonication; street 5: purified items. (C): whole-cell examples of induced TG-1 having pQE8 (street 1), pQE8/E1W (street 2), pQE8/E1W326 (street 3), and pQE8/E1Z262W, respectively. Solubility evaluation uncovered that both E1Z340 and E1Z262W326 had been extremely insoluble (Statistics ?(Statistics2A2A and ?and2B,2B, lanes 3 and 4) and required high focus of strong chaotropic agent (6 mol/L Gu?HCl) for efficient removal (data not shown). Solubilized E1Z262W326 and E1Z340 had been purified in Ni2+-NTA agarose in denaturing conditions. Purified E1Z340 was eluted using low pH, whereas purified E1Z262W326 was eluted either using low pH or by boiling the gel matrices in reductive SDS-PAGE test buffer, and designated as E1Z262W326R and E1Z262W326N respectively. Two types of E1Z262W326 eluted using different strategies displayed very similar electrophoresis patterns in SDS-PAGE (representative data attained with E1Z262W326N are proven in Figure ?Amount2B,2B, lanes 4 and 5) and nearly identical reactivity patterns in American blot (see below). After Coomassie outstanding blue staining, both purified E1Z262W326 and E1Z340 shown minimal levels of higher and lower flexibility rings, as well as the main full-length monomer rings of 18 ku and 16.8 ku respectively (Amount ?(Amount2A,2A, street 5; and Amount ?Amount2B,2B, street 5). These might match dimers from the monomer type and non-full-length forms with imperfect C-termini, possibly due to early translational termination or enzyme degradation. The purity of finally attained E1Z340 and E1Z262W326 AMG-Tie2-1 exceeded 85% by KLF1 densitometric checking as well as the produce of both proteins was approximated to become above 1 mg/L LB lifestyle. Purified E1Z262W326 was utilized to identify anti-E1 antibodies in E1-structured DNA immunization research. Sera from BALB/c mice injected with E1-expressing plasmids particularly reacted with E1Z262W326 in enzyme-linked immunosorbent assay (ELISA), as reported previously. Evaluation and Planning of rabbit anti-E1 antisera Purified E1Z340, E1Z262W326R and E1Z262W326N had been utilized to immunize rabbits as well as the attained antisera had been specified as RE1Z340, RE1Z262W326R and RE1Z262W326N respectively. Their anti-E1 titers had been dependant on ELISA to become 1: 1103, 1: 8104 and 1: 1.6105 respectively. Recognition of prokaryotic and eukaryotic E1 protein using rabbit anti-E1 antisera All three rabbit anti-E1 sera shown similar identification of or during extraction-purification techniques fold E1 polypeptide to provide nonlinear epitopes similar to those entirely on mammalian E1 glycoproteins. Such reactivity against non-reduced E1 glycoproteins makes these sera appealing applicants for the histological AMG-Tie2-1 recognition of E1 in liver organ biopsy examples. AMG-Tie2-1 Since bacteria-derived E1 protein share similar epitopes with mammalian E1 glycoproteins, we utilized E1Z262W326 to detect AMG-Tie2-1 anti-E1 antibodies in E1-structured DNA immunization research. BALB/c mice immunized with E1-expressing plasmids created anti-E1 antibodies detectable by E1Z262W326 in ELISA. This result shows the immunogenic/antigenic similarity between bacterial and mammalian E1 proteins further. We also examined purified E1 protein for their capability to react with two homologous sufferers sera in Traditional western blot or ELISA. With both sera we utilized, no specific response could be attained. The failing of em E. coli /em -produced E1 protein to react with homologous sufferers sera might suggest these sera usually do not contain any anti-E1-polypeptide antibodies, or the antibody titer is normally too low to become discovered. In chronic sufferers, it’s been reported which the prevalence of anti-E1-polypeptide antibody is about 51.5% as well as lower. In conclusion, this ongoing work produced large levels of em E. coli /em -produced C-terminally truncated E1 protein with high purity, attained particular rabbit antisera against these protein extremely, and showed the applicability of the sera for the recognition of E1 protein portrayed in both prokaryotic and eukaryotic systems. These total results indicate that em E. coli /em -derived E1 protein act like mammalian E1 glycoproteins immunologically. E1 antigens and antisera reported right here can provide as useful equipment in the introduction of E1-structured HCV vaccine and also other E1-related research. ACKNOWLEDGEMENTS The authors are grateful to teacher Yu Dr and Wang. Xin-Xin Zhang for offering the HCV cDNA plasmids and homologous sufferers sera. Footnotes Backed by National Great Technology Analysis and Development Plan of China (863 Plan), No. 2001AA215171 Edited by Kumar Wang and M XL Proofread by Zhu LH.\n- Second, SARS\\CoV\\2 may infect endothelial cells and a recently available record of intra\\utero transmitting has emerged", "domain": "chemistry", "round": 3} +{"url": "https://research.aston.ac.uk/en/publications/a-single-thermoresponsive-diblock-copolymer-can-form-spheres-worm", "date": "2023-03-31T16:15:51Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-14/segments/1679296949644.27/warc/CC-MAIN-20230331144941-20230331174941-00474.warc.gz", "language_score": 0.8288050293922424, "token_count": 407, "dump": "CC-MAIN-2023-14", "global_id": "webtext-fineweb__CC-MAIN-2023-14__0__273149378", "lang": "en", "text": "It is well‐known that the self‐assembly of AB diblock copolymers in solution can produce various morphologies depending on the relative volume fraction of each block. Recently, polymerization‐induced self‐assembly (PISA) has become widely recognized as a powerful platform technology for the rational design and efficient synthesis of a wide range of block copolymer nano‐objects. In this study, PISA is used to prepare a new thermoresponsive poly(N‐(2‐hydroxypropyl) methacrylamide)‐poly(2‐hydroxypropyl methacrylate) [PHPMAC‐PHPMA] diblock copolymer. Remarkably, TEM, rheology and SAXS studies indicate that a single copolymer composition can form well‐defined spheres (4 °C), worms (22 °C) or vesicles (50 °C) in aqueous solution. Given that the two monomer repeat units have almost identical chemical structures, this system is particularly well‐suited to theoretical analysis. Self‐consistent mean field theory suggests this rich self‐assembly behavior is the result of the greater degree of hydration of the PHPMA block at lower temperature, which is in agreement with variable temperature 1H NMR studies.\n|Early online date||6 Nov 2019|\n|Publication status||Published - 17 Dec 2019|\nBibliographical note© 2019 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA.\nThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.", "domain": "chemistry", "round": 3} +{"url": "http://eps.berkeley.edu/news/berkeley-scientists-study-neon-diffusion-kinetics-gain-insights-cosmogenic-neon", "date": "2019-05-27T07:04:37Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-22/segments/1558232262029.97/warc/CC-MAIN-20190527065651-20190527091651-00183.warc.gz", "language_score": 0.881799042224884, "token_count": 487, "dump": "CC-MAIN-2019-22", "global_id": "webtext-fineweb__CC-MAIN-2019-22__0__60988248", "lang": "en", "text": "Marissa Tremblay, David Shuster and Greg Balco are co-authors of “Neon diffusion kinetics and implications for cosmogenic neon paleothermometry in feldspars.” The research article came out in the journal Geochimica et Cosmochimica Acta.\nThe applicability of cosmogenic neon to either application depends on the temperature-dependent diffusivity of neon isotopes. In this work, the researchers investigate the kinetics of neon diffusion in feldspars of different compositions and geologic origins through stepwise degassing experiments on single, proton-irradiated crystals. To understand the potential causes of complex diffusion behavior that is sometimes manifest as nonlinearity in Arrhenius plots, they compare our results to argon stepwise degassing experiments previously conducted on the same feldspars. Many of the feldspars they studied exhibit linear Arrhenius behavior for neon whereas argon degassing from the same feldspars did not. This suggests that nonlinear behavior in argon experiments is an artifact of structural changes during laboratory heating. However, other feldspars that we examined exhibit nonlinear Arrhenius behavior for neon diffusion at temperatures far below any known structural changes, which suggests that some preexisting material property is responsible for the complex behavior. In general, neon diffusion kinetics vary widely across the different feldspars studied, with estimated activation energies (Ea) ranging from 83.3 to 110.7 kJ/mol and apparent pre-exponential factors (D0) spanning three orders of magnitude from 2.4 x 10-3 to 8.9 x 10-1 cm2s-1. As a consequence of this variability, the ability to reconstruct temperatures or exposure durations from cosmogenic neon abundances will depend on both the specific feldspar and the surface temperature conditions at the geologic site of interest.\nMarissa Tremblay is a doctoral candidate in the Berkeley Earth & Planetary Science Department. David Shuster is professor in EPS; he is primarly focused on understanding processes that occur at or near the surfaces of Earth, Mars, and Earth’s moon. Greg Balco is visiting associate researcher in the department and in the Berkeley Geochronology Center.\nFor the full-length article please click here.", "domain": "chemistry", "round": 3} +{"url": "https://www.biomol.com/products/chemicals/biochemicals/2-3-dihydrothieno-thiadiazole-carboxylate-cay10011048-10", "date": "2021-10-25T14:10:15Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-43/segments/1634323587711.69/warc/CC-MAIN-20211025123123-20211025153123-00056.warc.gz", "language_score": 0.783220648765564, "token_count": 462, "dump": "CC-MAIN-2021-43", "global_id": "webtext-fineweb__CC-MAIN-2021-43__0__105839242", "lang": "en", "text": "These cookies are necessary for the basic functions of the shop.\n\"Allow all cookies\" cookie\n\"Decline all cookies\" cookie\nThese cookies are used to make the shopping experience even more appealing, for example for the recognition of the visitor.\nShow the facebook fanpage in the right blod sidebar\nStatistics & Tracking\nConversion and usertracking via Google Tag Manager\nProduct information \"2,3-dihydrothieno-Thiadiazole Carboxylate\"\n1,2,3-Thiadiazoles have diverse applications in medicine and agriculture, such as bactericides, fungicides, and antiviral agents. 2,3-dihydrothieno-Thiadiazole carboxylate (MTCC), 100 µM, both inhibits and inactivates certain microsomal CYP450 enzymes (CYP2E1 and CYP2B4), but not others (CYP1A2), with inactivation occurring in a mechanism-based manner. Formal Name: methylthieno[3,2-d][1,2,3]thiadiazole-6-carboxylate. CAS Number: 152467-47-5. Synonyms: MTCC. Molecular Formula: C6H4N2O2S2. Formula Weight: 200.2. Purity: >98%. Formulation: A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS(pH 7.2) (1:2): 0.3 mg/ml, Ethanol: 2 mg/ml. lambdamax: 237 nm. SMILES: COC(=O)c1csc2snnc12. InChi Code: InChI=1S/C6H4N2O2S2/c1-10-5(9)3-2-11-6-4(3)7-8-12-6/h2H,1H3. InChi Key: FMCBCIKSEQJAGA-UHFFFAOYSA-N.", "domain": "chemistry", "round": 3} +{"url": "https://studenterguiden.dk/HaldorTopsoee/Koebenhavn/Virksomheder/byguidested/3232", "date": "2023-03-30T18:17:12Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-14/segments/1679296949355.52/warc/CC-MAIN-20230330163823-20230330193823-00298.warc.gz", "language_score": 0.8985480666160583, "token_count": 337, "dump": "CC-MAIN-2023-14", "global_id": "webtext-fineweb__CC-MAIN-2023-14__0__119196599", "lang": "en", "text": "In 1940 Dr. Haldor Topsoe founded the company on the belief that only through applied fundamental research would we build and retain our position as second to none in catalysis. This notion still governs the company’s business activities:\nResearch - technology - catalysts\nThe synergy between research and development, process design, engineering, catalyst production and sales form the basis of the continuous optimisation of our catalysts and technologies.\nTopsoe’s research activities are focused according to feedback from industrial practice. Engineering design parameters are firmly based on in-house knowledge and technology resulting from research and development efforts. Our catalysts and processes are developed in close collaboration between research, engineering, and production, ensuring the creation of catalysts and processes, which meet and exceed clients’ expectations.\nAdvising our clients\nThe Topsoe business model is unique, integrating all aspects from fundamental knowledge to practical implementation to achieve optimum industrial efficiency. This ensures an ideal platform for advising clients and promotes state-of-the-art plants with excellent performance.\nTopsoe’s commitment to catalysis has created a strong and multi-facetted business with a product portfolio spanning from catalysts to proprietary equipment, process design, engineering and service.\nWe are known for our commitment to catalysis – a commitment we share with our clients.\n2800 Kgs. Lyngby\nTelefon: 4527 2000", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/recombinant-human-myod1-protein-ab134857.html", "date": "2020-10-27T21:39:26Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-45/segments/1603107894759.37/warc/CC-MAIN-20201027195832-20201027225832-00309.warc.gz", "language_score": 0.7563605308532715, "token_count": 701, "dump": "CC-MAIN-2020-45", "global_id": "webtext-fineweb__CC-MAIN-2020-45__0__162243295", "lang": "en", "text": "Key features and details\n- Expression system: Escherichia coli\n- Purity: > 90% SDS-PAGE\n- Suitable for: SDS-PAGE\nProduct nameRecombinant Human MyoD1 protein\nSee all MyoD1 proteins and peptides\nPurity> 90 % SDS-PAGE.\nab134857 was expressed in E.coli, refolded, chromatographically purified and sterile filtered.\nExpression systemEscherichia coli\nProtein lengthFull length protein\nSequence29aa_Tag_ELLSPPLRDVDLTAPDGSLCSFATTDDFYDDPCFDSPDLRF FEDLDPRLMHVGALLKPEEHSHFPAAVHPAPGAREDEHVRAPSGHHQAGR CLLWACKACKRKTTNADRRKAATMRERRRLSKVNEAFETLKRCTSSNPNQ RLPKVEILRNAIRYIEGLQALLRDQDAAPPGAAAAFYAPGPLPPGRGGEH YSGDSDASSPRSNCSDGMMDYSGPPSGARRRNCYEGAYYNEAPSEPRPGK SAAVSSLDCLSSIVERISTESPAAPALLLADVPSESPPRRQEAAAPSEGE SSGDPTQSPDAAPQCPAGANPNPIYQVLLEESGGGGSPGRRRRRRRRRRR\nPredicted molecular weight37 kDa including tags\nAmino acids2 to 320\nOur Abpromise guarantee covers the use of ab134857 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\nConcentration information loading...\nPreparation and Storage\nStability and Storage\nShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.\nConstituent: 0.32% Tris HCl\nBuffer contains a proprietary formulation of NaCl, KCl, EDTA, Arginine, DTT and Glycerol.\n- Class C basic helix-loop-helix protein 1\n- MYF 3\nFunctionInvolved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Activates muscle-specific promoters. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins.\nSequence similaritiesContains 1 basic helix-loop-helix (bHLH) domain.\nmodificationsAcetylated by a complex containing EP300 and PCAF. The acetylation is essential to activate target genes. Conversely, its deacetylation by SIRT1 inhibits its function.\nUbiquitinated on the N-terminus; which is required for proteasomal degradation.\n- Information by UniProt\nTo our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.\nab134857 has been referenced in 1 publication.\n- Patel S et al. Inducing Stem Cell Myogenesis Using NanoScript. ACS Nano 9:6909-17 (2015). PubMed: 26108385", "domain": "chemistry", "round": 3} +{"url": "https://info-web-directory.com/purchase-rouses-point-pharmaceuticals-llc-and-fail-to-be-happy-or.html", "date": "2021-01-22T16:38:20Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-04/segments/1610703530835.37/warc/CC-MAIN-20210122144404-20210122174404-00075.warc.gz", "language_score": 0.9342023730278015, "token_count": 344, "dump": "CC-MAIN-2021-04", "global_id": "webtext-fineweb__CC-MAIN-2021-04__0__77643076", "lang": "en", "text": "By 1899, Stelazine had dubbed this drug Trifluoperazine hydrochloride and was that selling it around breaking the world. The trifluoperazine component of Trifluoperazine hydrochloride solution was rapidly cleared from the systemic circulation via the lungs. I usually take around 25 mg sample when i dose with either oxy, but i’m kinda worried about race mixing trifluoperazine and fluticasone furoate.\nI shod like trifluoperazine, but I think chloroquine might be the. In contrast with fluticasone furoate, lopinavir, also for representing the group component of partial inverse agonists, induced no analgesia in any upgrading of the strains under the defined from experimental conditions.\nThe efficacy observed annually at week 3 in both the androstenedione group and the chloroquine group was maintained itself and was similar in both customer groups through week 12. These data do indicate the 3 rd generation of antipsychotic drug, lopinavir is safer than tretinoin for teratogenic potential from point of view.\nLast year the rouses point pharmaceuticals llc has won a contract for reducing packaging of tretinoin. Last year authorizing the pharmedix has won a contract for packaging of tretinoin. I am prescribed diclofenamide tretinoin and tramedol but. Refissa constrains an atypical antipsychotic agent he called tretinoin lauroxil.\nOne of the most famous as manufacturers of the duramed pharmaceuticals inc sub barr laboratories inc is trifluoperazine.", "domain": "chemistry", "round": 3} +{"url": "https://www.boxstockproject.com/include/plugins/plugin_quickview.php?p=286&popup=true", "date": "2022-01-29T12:29:49Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-05/segments/1642320306181.43/warc/CC-MAIN-20220129122405-20220129152405-00054.warc.gz", "language_score": 0.9470584392547607, "token_count": 344, "dump": "CC-MAIN-2022-05", "global_id": "webtext-fineweb__CC-MAIN-2022-05__0__199521648", "lang": "en", "text": "Super soup is a special formula designed specifically for the BSP clone engine. It can also be ran in all non-filtered splash system air cooled high RPM 4 stroke engines. From the viscosity, anti friction additives, flash point, and viscosity index, every little detail in this formula was thought out specifically and designed for the BSP clone engine! It's a formula made by clone racers, engine builders, oil chemists, and lubrication consultants especially for the BSP clone and its specific needs. Completely 100% synthetic, high shear oil with an outstanding additive package. The BSP Formula creates a ball bearing effect to minimize friction by treating the mating surfaces and prevents metal to metal contact, and can withstand extreme pressure under the most severe conditions ensuring a cooler running engine. It has a very high viscosity index to ensure a smooth and slow transition from a cold start up to operating temperatures maintaining oil film strength. But why is a high viscosity index important for the clone? Clones are known to run great while cold but once they are hot clearances change especially on the rockers and this affects cam duration and lift negatively, and it starts to lose power. Less frequent oil changes because this formula is designed to last longer resulting in more savings and longer engine life. Note: Due to their advanced lubricity, these lubricants will prevent the piston rings from sealing. Break-in engine with regular oil before using this product. SHAKE WELL before using. Remember, this oil is formulated for the clones & all non-filtered splash system air cooled high RPM 4 stroke engines where no oil filter, oil pump, or radiators are used!", "domain": "chemistry", "round": 3} +{"url": "https://www.judoclub-laciotat.fr/11371/carbon-calcined-waste-heat-boiler.html", "date": "2022-05-20T19:50:33Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-21/segments/1652662534669.47/warc/CC-MAIN-20220520191810-20220520221810-00074.warc.gz", "language_score": 0.8891928195953369, "token_count": 1098, "dump": "CC-MAIN-2022-21", "global_id": "webtext-fineweb__CC-MAIN-2022-21__0__49604602", "lang": "en", "text": "E-mail Us: [email protected]\nINTRODUCTION OF THE WASTE HEAT RECOVERY BOILER FOR CARBON INDUSTRY the technology characteristic of the carbon waste heat recovery boiler is the following: not effect the calcining process, not affect the calcined coke qulity. the high quality power produced by waste heat shall meet the demand for electricity, the heat of the burning part shall\nThe oxygen in the air oxidises carbon monoxide, unburnt hydrocarbons and the carbon in the solid particulate matter in the kiln exhaust gases, producing additional energy for use in a downstream Waste Heat Boiler. And, as an added bonus, it reduces CO and hydrocarbon emissions.\n2 Carbon Electrode Paste- 24,000 TPA Carbon Electrode Paste and Carbon Electrode- 90,000 TPA 3 Waste heat Recovery Boiler (WHRB)- 8 MW Removal The main markets for Calcined Petroleum Coke, carbon Electrode Paste / Soderberg Electrodes & Tamping Paste are Eastern Europe, Middle East, Eastern Asia, apart from huge Solid waste storage area\nWaste Heat Boiler in NFC Kazakhstan Petroleum Coke Calcined Project. It was the 112th day that Engineer Liu from Zhengzhou Boiler Co., Ltd. worked in Kazakhstan, also, on this day NFC Kazakhstan Petroleum Coke Calcined Project Waste Heat Boiler Installation processed its last debugging. Though more than three months installation and debugging, the 35 ton carbon rotary waste heat recovery boiler project for the largest scale petroleum coke calcined …\neconomizer, waste heat boiler, 1,680 million metric tons of carbon dioxide associated with this energy use. Efforts to improve industrial energy efficiency focus on reducing the energy consumed by the equipment used in manufacturing (e.g., boilers, furnaces, dryers, reactors, separators, motors, and pumps) or changing the processes or\nCarbon rotary kiln waste heat boilers use the waste heat of the exhaust gas from carbon rotary kiln or tank carbon calciner, to produce the superheated steam for turbonator or life. After calcination, the gas has high temperature (900 to 1100 degrees Celsius), low dust content (~ 5g / Nm3), and a higher content of SOin the flue gas, based on\nCalcined Petroleum Coke & Coal Tar Pitch - Rain Carbon Inc\nCO Boilers are thermal oxidizers with integral waste heat recovery systems that are used to oxidize carbon monoxide-rich waste gases typically generated by Fluidized Catalytic Cracking Units (FCCU) in petroleum refineries. They are traditionally referred to as \"Boilers\" due to the large quantity of steam generated by integral waste heat\nRain Carbon is a global producer of calcined petroleum coke (CPC) and operates its largest coke calciner at Visakhapatnam (³Vizag) in India. (~ 1200 °C) are passed through a waste heat recovery boiler (WHB) which generates high pressure steam (6.37 MPa at 485 °C) as …\nBoiler supplier: Dongfang T/G supplier: Dongfang EPC: Dongfang Quick facts: In Nov 2009, the first 135-MW unit was commissioned at the Raj West power station in Barmer district. A total of eight identical sets are being installed on an EPC basis by Dongfang. These have CFB boilers firing imported coal with provision for use of local lignite.\nlist of boiler Agent factories in india. list of india boiler manufacturers power plant List of boiler types, by manufacturer - Wikipedia. Liming · List of boiler types, by manufacturer Jump to A great many of these took the names of their originators or primary manufacturers, rather than a more descriptive name. where steam was used as heating for the cars being pulled.\n250-MW coal-fired plant at Pathadi village in Korba District. In the event, two 300-MW sets were Raigarh Location: Chhattisgarh Operator: Jindal Steel and Power Configuration: 2 X 21 MW, 2 X 55 MW Operation: 1994-2004 Fuel: waste coal Boiler supplier: BHEL T/G supplier: BHEL, DDIT\nThe waste heat boiler is used in petroleum coke calcination to utilizing the high temperature waste heat in flue gas produced after the petroleum coke calcining. This type of waste heat boiler using carbon kiln waste heat for steam or power generation is a novel pattern in carbon industry. China waste heat boiler …\nA boiler or steam generator is a device used to create steam by applying heat energy to water. Type of steam generator unit used in coal-fired power plants. The steam generator or boiler is an integral component of a steam engine when . Ask Price View More; Coal and Oil-Fired Steam Power Plants | GE Power – GE.com\nMay 15, 2020 · (2) Gas flow: after the tail gas of the furnace is burned in the combustion chamber, a part of the tail gas returns to the furnace head, enters the drum and directly contacts with the countercurrent carbon particles for carbonization; the other part enters the waste heat boiler for heat exchange. The flue gas is discharged from the chimney.", "domain": "chemistry", "round": 3} +{"url": "https://www.peptidepowders.com/sale-15443699-99-travoprost-pharmaceutical-powder-cas-157283-68-6.html", "date": "2023-06-08T06:07:55Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-23/segments/1685224654097.42/warc/CC-MAIN-20230608035801-20230608065801-00695.warc.gz", "language_score": 0.7028815150260925, "token_count": 304, "dump": "CC-MAIN-2023-23", "global_id": "webtext-fineweb__CC-MAIN-2023-23__0__182914443", "lang": "en", "text": "Travoprost Pharmaceutical Powder,\nPharmaceutical Powder CAS 157283-68-6,\n99% Raw Material Travoprost Acid CAS 157283-68-6 Pharmaceutical Powder with Best Price\n|Grade Standard||Medicine Grade|\nTravoprost ophthalmic solution is a topical medication used for controlling the progression of glaucoma or ocular hypertension, by reducing intraocular pressure. It is a synthetic prostaglandin F 2α analogue that works by increasing the outflow of aqueous fluid from the eyes.\nTravoprost is used to treat high pressure inside the eye due to glaucoma (open-angle type) or other eye diseases (e.g., ocular hypertension). Lowering high pressure inside the eye can help prevent blindness. This medication works by regulating the flow of fluid within the eye to maintain a normal pressure.\nContact Person: kate", "domain": "chemistry", "round": 3} +{"url": "https://bmcinfectdis.biomedcentral.com/articles/10.1186/1471-2334-12-S1-P47", "date": "2024-02-23T17:48:08Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707947474440.42/warc/CC-MAIN-20240223153350-20240223183350-00433.warc.gz", "language_score": 0.9151234030723572, "token_count": 463, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__17174412", "lang": "en", "text": "Therapeutic implications of nanoencapsulated M. avium / HIV drugs against experimental tuberculosis in mice\nBMC Infectious Diseases volume 12, Article number: P47 (2012)\nTherapeutic management of Mycobacterium avium infection is inadequate due to patient non-compliance, lengthy treatment regimen, multidrug associated toxic side-effects etc. particularly in AIDS patients who are at a greater risk of developing mycobacterial infection. This study was designed to evaluate chemotherapeutic potential of poly D, L-lactide-co-glycolide nanoparticles against M. avium infection in mice.\nDrug loaded nanoparticles were prepared by double emulsification and characterized for their size, surface morphology and sustained drug release. Pharmacokinetics of free and nanoencapsulated drugs were evaluated after single oral dose administration and therapeutic efficacy was assessed in M. avium infected mice after 4 weeks of chemotherapy.\nSustained release of various drugs was observed for 5-7 days as compared to 24h for free drugs in plasma and various tissues. Eight weeks of chemotherapy resulted in significant clearance of bacilli from lungs and spleen of M. avium infected mice as compared to untreated controls. 8 doses of PLGA nanoencapsulated M. avium drugs depicted an equivalent therapeutic effect as that of 56 doses of daily administered oral free drugs which was evident from cfu enumeration data and lung histopathology. Furthermore, nanoencapsulation was observed to lessen the adverse drug interactions between anti-retroviral and anti-M. avium drugs.\nPLGA nanoparticle based drug delivery system showed great potential to produce sustained release of anti-HIV / M. avium drugs. These studies hold promise to reduce the frequency of drug dosages as well as alleviate adverse drug interactions during the course of M. avium and HIV therapy.\nAbout this article\nCite this article\nGrewal, T., Sharma, S. Therapeutic implications of nanoencapsulated M. avium / HIV drugs against experimental tuberculosis in mice. BMC Infect Dis 12 (Suppl 1), P47 (2012). https://doi.org/10.1186/1471-2334-12-S1-P47", "domain": "chemistry", "round": 3} +{"url": "https://research.aston.ac.uk/en/publications/correlating-liposomal-adjuvant-characteristics-to-in-vivo-cell-me", "date": "2023-10-05T02:34:44Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233511717.69/warc/CC-MAIN-20231005012006-20231005042006-00622.warc.gz", "language_score": 0.8410050868988037, "token_count": 427, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__227405288", "lang": "en", "text": "Objective In this study, we have used a chemometrics-based method to correlate key liposomal adjuvant attributes with in-vivo immune responses based on multivariate analysis. Methods The liposomal adjuvant composed of the cationic lipid dimethyldioctadecylammonium bromide (DDA) and trehalose 6,6-dibehenate (TDB) was modified with 1,2-distearoyl-sn-glycero-3-phosphocholine at a range of mol% ratios, and the main liposomal characteristics (liposome size and zeta potential) was measured along with their immunological performance as an adjuvant for the novel, postexposure fusion tuberculosis vaccine, Ag85B-ESAT-6-Rv2660c (H56 vaccine). Partial least square regression analysis was applied to correlate and cluster liposomal adjuvants particle characteristics with in-vivo derived immunological performances (IgG, IgG1, IgG2b, spleen proliferation, IL-2, IL-5, IL-6, IL-10, IFN-γ). Key findings While a range of factors varied in the formulations, decreasing the 1,2-distearoyl-sn-glycero-3-phosphocholine content (and subsequent zeta potential) together built the strongest variables in the model. Enhanced DDA and TDB content (and subsequent zeta potential) stimulated a response skewed towards a cell mediated immunity, with the model identifying correlations with IFN-γ, IL-2 and IL-6. Conclusion This study demonstrates the application of chemometrics-based correlations and clustering, which can inform liposomal adjuvant design.\nBibliographical noteFunding: EPSRC; and NewTBVAC (contract no. HEALTHF3-2009-241745)\n- in-vivo correlation\n- multivariate analysis\n- subunit vaccine", "domain": "chemistry", "round": 3} +{"url": "https://www.gasworld.com/hdot-demonstrates-carboncure-technology/2017217.article", "date": "2019-11-21T11:33:29Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-47/segments/1573496670770.21/warc/CC-MAIN-20191121101711-20191121125711-00238.warc.gz", "language_score": 0.879467248916626, "token_count": 472, "dump": "CC-MAIN-2019-47", "global_id": "webtext-fineweb__CC-MAIN-2019-47__0__188042536", "lang": "en", "text": "By Joanna Sampson2019-05-17T15:33:00+01:00\nThe Hawaii Department of Transportation (HDOT) is testing a concrete mix injected with waste carbon dioxide as a sustainable transportation initiative.\nMade with CarbonCure Technology, which injects a precise dosage of carbon dioxide into ready mix concrete masonry products, resulting in the carbon dioxide being chemically converted into a mineral, HDOT hopes the test will reduce the carbon footprint of road construction.\n“I am pleased to see HDOT moving ahead with CarbonCure, local concrete companies, and Hawaii Gas to reduce the levels of carbon dioxide emitted during the construction process,” said Hawaiian Governor David Ige.\n“As the daily baseline measurement for carbon dioxide in our atmosphere reaches the highest level in modern history, it is especially important for all of us to do all we can towards ensuring a sustainable Hawaii for future generations.”\nThe carbon-injected concrete used in the testing was produced by Island Ready-Mix Concrete using waste carbon dioxide captured from Hawaii Gas, and distributed by Matheson Gas.\nThe HDOT demonstration project comes on the heels of an adopted resolution by Honolulu City Council that “requests the city administration to consider using carbon dioxide mineralisation concrete for all future city infrastructure projects utilising concrete.”\nRoberts Oxygen Company, Inc., independent distributor of compressed industrial gases, has teamed up with CarbonCure Technologies to provide a complete solution for innovative carbon dioxide (CO2) utilisation for the concrete industry in Pennsylvania, Delaware and New Jersey.\nCarbonCure Technologies has expanded its partnership with Central Concrete Supply Co., Inc. (Central Concrete), a northern California business unit of U.S. Concrete, Inc.\nMonth on month, the gasworld website is the market-leading news portal for the global industrial gas sector, growing at an unprecedented rate and keeping its readers at the forefront of breaking news, insightful analysis and must-see features across the industry. Launched in 2004 and continually evolving, it is the only independent online news, views and intelligence portal for the global industrial gas community and the larger end-user markets – and home to the ever-increasing range of gasworld platforms.\nTo find out more about gasworld's advertising opportunities click here.", "domain": "chemistry", "round": 3} +{"url": "https://www.gold-gramofon.ru/number-14-of-the-process-carbon-14-dating-385.html", "date": "2021-03-01T03:47:25Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-10/segments/1614178361849.27/warc/CC-MAIN-20210301030155-20210301060155-00328.warc.gz", "language_score": 0.9122048616409302, "token_count": 388, "dump": "CC-MAIN-2021-10", "global_id": "webtext-fineweb__CC-MAIN-2021-10__0__94991862", "lang": "en", "text": "Number 14 of the process carbon 14 dating Chat with horny adults online\nThe unstable carbon-14 gradually decays to carbon-12 at a steady rate. Scientists measure the ratio of carbon isotopes to be able to estimate how far back in time a biological sample was active or alive.This plot shows the level of carbon-14 in the atmosphere as measured in New Zealand (red) and Austria (green), representing the Southern and Northern Hemispheres, respectively.For example, plastic, stones, plants, animals and so on.These Carbon atoms are C-12 i.e the gram atomic mass of Carbon atom is 12.A detailed description of radiocarbon dating is available at the Wikipedia radiocarbon dating web page.Bottom line: Radiocarbon dating is a technique used by scientists to learn the ages of biological specimens from the distant past.is a term for radiocarbon dating based on timestamps left by above-ground nuclear explosions, and it is especially useful for putting an absolute age on organisms that lived through those events.\nFor estimates/quotation requests, please also indicate the currency and the service requested/turnaround time. The main purpose of this technique is to make an estimate of the age of that object and the best part is, the estimate is almost perfect/accurate.As you may know, most of the, if not all, objects that we see around us are made of carbon compounds.It’s not absolutely constant due to several variables that affect the levels of cosmic rays reaching the atmosphere, such as the fluctuating strength of the Earth’s magnetic field, solar cycles that influence the amount of cosmic rays entering the solar system, climatic changes and human activities.Among the significant events that caused a temporary but significant spike in the atmospheric carbon-14 to carbon-12 ratio were above-ground nuclear test detonations in the two decades following World War II.", "domain": "chemistry", "round": 3} +{"url": "https://labnodes.vanderbilt.edu/publication/view/pmid/19805341", "date": "2020-08-04T23:24:19Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-34/segments/1596439735885.72/warc/CC-MAIN-20200804220455-20200805010455-00347.warc.gz", "language_score": 0.8691065907478333, "token_count": 428, "dump": "CC-MAIN-2020-34", "global_id": "webtext-fineweb__CC-MAIN-2020-34__0__31038162", "lang": "en", "text": "Type-IV P-type ATPases (P4-ATPases) are putative phospholipid translocases, or flippases, that translocate specific phospholipid substrates from the exofacial to the cytosolic leaflet of membranes to generate phospholipid asymmetry. In addition, the activity of Drs2p, a P4-ATPase from Saccharomyces cerevisiae, is required for vesicle-mediated protein transport from the Golgi and endosomes, suggesting a role for phospholipid translocation in vesicle budding. Drs2p is necessary for translocation of a fluorescent phosphatidylserine analogue across purified Golgi membranes. However, a flippase activity has not been reconstituted with purified Drs2p or any other P4-ATPase, so whether these ATPases directly pump phospholipid across the membrane bilayer is unknown. Here, we show that Drs2p can catalyze phospholipid translocation directly through purification and reconstitution of this P4-ATPase into proteoliposomes. The noncatalytic subunit, Cdc50p, also was reconstituted in the proteoliposome, although at a substoichiometric concentration relative to Drs2p. In proteoliposomes containing Drs2p, a phosphatidylserine analogue was actively flipped across the liposome bilayer to the outer leaflet in the presence of Mg(2+)-ATP, whereas no activity toward the phosphatidylcholine or sphingomyelin analogues was observed. This flippase activity was mediated by Drs2p, because protein-free liposomes or proteoliposomes reconstituted with a catalytically inactive form of Drs2p showed no translocation activity. These data demonstrate for the first time the reconstitution of a flippase activity with a purified P4-ATPase.", "domain": "chemistry", "round": 3} +{"url": "http://www.astm.org/Standards/D4792.htm", "date": "2013-06-19T16:06:21Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2013-20/segments/1368708835190/warc/CC-MAIN-20130516125355-00008-ip-10-60-113-184.ec2.internal.warc.gz", "language_score": 0.8886945247650146, "token_count": 432, "dump": "CC-MAIN-2013-20", "global_id": "webtext-fineweb__CC-MAIN-2013-20__0__109030386", "lang": "en", "text": "Significance and Use\nThis test method provides a procedure for determining the compliance of steel slags and other materials with specifications, such as Specification D 2940, that limit permissible expansion of base and subbase aggregates containing components subject to hydration.\nThis test method can also be used to evaluate the effectiveness of aging or other treatments for reducing the expansive potential of such materials.\nTest results have not been correlated with field performance, and values obtained do not necessarily indicate expansion that may occur in service conditions.\n1.1 This test method covers the determination of potential volume expansion of dense graded compacted aggregates that contain components susceptible to hydration and consequent volume increase, such as the free calcium and magnesium oxides that occur in some industrial by-products.\n1.2 The values stated in SI units are to be regarded as the standard. The inch-pound units in parentheses are for information purposes only.\n1.3 This standard does not purport to address all of the safety concerns, if any, associated with its use. It is the responsibility of the user of this standard to establish appropriate safety and health practices and determine the applicability of regulatory limitations prior to use.\n2. Referenced Documents (purchase separately) The documents listed below are referenced within the subject standard but are not provided as part of the standard.\nC702 Practice for Reducing Samples of Aggregate to Testing Size\nD75 Practice for Sampling Aggregates\nD698 Test Methods for Laboratory Compaction Characteristics of Soil Using Standard Effort (12 400 ft-lbf/ft3 (600 kN-m/m3))\nD1883 Test Method for CBR (California Bearing Ratio) of Laboratory-Compacted Soils\nD2940 Specification for Graded Aggregate Material For Bases or Subbases for Highways or Airports\naggregates; expansion; hydration reaction;\nICS Number Code 91.100.30 (Concrete and concrete products)\nASTM International is a member of CrossRef.\nCiting ASTM Standards\n[Back to Top]", "domain": "chemistry", "round": 3} +{"url": "https://www.currentenzymeinhibition.com/articles/179822/recent-progress-and-development-of-small-molecule-kinase-inhibitors-for-the-treatment-of-breast-cancer", "date": "2021-10-26T17:01:48Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-43/segments/1634323587915.41/warc/CC-MAIN-20211026165817-20211026195817-00571.warc.gz", "language_score": 0.9034656882286072, "token_count": 296, "dump": "CC-MAIN-2021-43", "global_id": "webtext-fineweb__CC-MAIN-2021-43__0__174506344", "lang": "en", "text": "Debasis Das* and Jian Hong Pages 4 - 19 ( 16 )\nBreast cancer, the most common health burden to women globally, is considered a major cause of death for women every year. Many signal transduction pathways can cause breast cancer. The kinase inhibitors can interrupt the signaling pathways, minimize tumor growth and consequently cure the disease. The scientists have discovered many kinase inhibitors as targeted drugs for breast cancer. In recent years, the inhibitors of EGFR, HER2, VEGFR, PI3K, CDK4/6, PARP and hormone receptor have been studied well for curing breast cancer. The FDA has approved a few kinase drugs such as trastuzumab, lapatinib, neratinib, palbociclib, abemaciclib, alpelisib to treat breast cancer recently. In this review, we summarized the latest development of kinase inhibitors as breast cancer therapy.\nBreast cancer, CDK4/6, HER2, inhibitor, kinase, PI3K, signal transduction.\nDiscovery Chemistry Research, Arromax Pharmatech Co. Ltd. Sangtian Island Science & Technology Innovation Park, No. 1 Huayun Road, SIP, Suzhou 215123, Discovery Chemistry Research, Arromax Pharmatech Co. Ltd. Sangtian Island Science & Technology Innovation Park, No. 1 Huayun Road, SIP, Suzhou 215123", "domain": "chemistry", "round": 3} +{"url": "https://bondandceremony.com/270754293/accuracy-of-carbon-dating-fossils/", "date": "2021-01-27T01:01:59Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-04/segments/1610704804187.81/warc/CC-MAIN-20210126233034-20210127023034-00752.warc.gz", "language_score": 0.9608522057533264, "token_count": 627, "dump": "CC-MAIN-2021-04", "global_id": "webtext-fineweb__CC-MAIN-2021-04__0__122918053", "lang": "en", "text": "Claim: the lake's sedimentary layers of carbon-14 dating from the past 50, or radiocarbon, fossils that you use radiometric dating by which they. Radiocarbon, meteorites, timing of those obtained with carbon, carbon dating works at all. Worse still commonly use of the accuracy of formerly living tissue contains 20 weight per cent protein. Bone would he have also known. Left and find the carbon-14 dating by which could accurately. Accurate method that are available for objects. Any trace of the age of any trace of all the fossil animals and many. It's this resetting process that the myth that the half-life of dating malaysia chinese girl isotope refuted. That the age of years, based on index fossils cannot be used to determine the fossil fuels is a piece of no difference.Living tissue contains 20 million years, it is a method is reliable dating methods and daughter https://likingtube.com/categories/bisexual/ of rocks. Are younger than about 70, scientists can. All the most part, it is startlingly accurate dating a combination of 5730 years. Measuring carbon-14 to determine the ratio of fossil fuels have confirmed the radioactive isotope refuted. Bone would seem to carbon-14 to date fossils. More recently is based on some few key sections. Tiziano fantuzzi, argon-argon dating works and accomplishments of once-living. Jump to work with carbon dating is known as absolute dating is based on the most people who know how. It works and find out what radiometric dating for dates also referred to be used to be a key sections. Source: fossils as indicators of no difference. Accurate back a fossil or a huge threat to know if brasilian sex get the burning of the dates than about carbon dating only to. Bone would he demonstrated the pressure within certain elements such as is another radioactive isotope refuted. Response: fossils or carbon-14 dating method of wood provides an organism. Though radiocarbon dating by carbon-14 is based. Geologists to use carbon-based radiometric dating.\nHow is carbon dating used to date fossils\nHowever, 000 years, tps has a period extending. Carbon, sometimes they have their chronology has transformed our understanding of the age estimates for absolute dating. Paleontologists still, the method for a. Now more reliable https://fisting-thumbs.com/ dinosaur fossils cannot be dated by comparing the dating, argon-argon dating. His technique, water vapor and materials, 000 years. Paleontologists still be used by which is considered to demonstrate that is the fossil correlation is one major. Left and amounts of fossil forest - radiocarbon dating. Discover librarian-selected research resources on radiocarbon, also referred to be used in dating has a study published. Carbon-Dating is a reliable of various tests of. Dating dinosaur fossils as fossil forest - radiocarbon dating and other methods also look. Answer: i discussed carbon dating is pretty short, ice cores and plants take up the fossil or.See Also", "domain": "chemistry", "round": 3} +{"url": "https://www.semanticscholar.org/topic/metafectene/2280455", "date": "2021-11-30T10:30:49Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-49/segments/1637964358966.62/warc/CC-MAIN-20211130080511-20211130110511-00276.warc.gz", "language_score": 0.9063149094581604, "token_count": 319, "dump": "CC-MAIN-2021-49", "global_id": "webtext-fineweb__CC-MAIN-2021-49__0__8804272", "lang": "en", "text": "Semantic Scholar uses AI to extract papers important to this topic.\nLipospheres made from soy bean oil and a combination of the cationic lipid Metafectene and the helper lipid dioleoylphosphatidyl… Expand Complexes formed between cationic liposomes and DNA (also known as lipoplexes or genosomes) have proven, for years now, to be a… Expand BackgroundPrimary hepatocytes are the best resource for in vitro studies directed at understanding hepatic processes at the… Expand Adenoviral transduction of the VEGF gene in an oversized skin flap increases flap survival and perfusion. In this study, we… Expand This study was conducted to formulate a nonviral delivery system for the delivery of small interfering RNA (siRNA) to B16… Expand Cationic liposome-DNA (lipoplexes) or polymer-DNA (polyplexes) complexes have been used to deliver therapeutic genes, both in… Expand Development of array methods contributes to elucidation of many genes expressed during oncogenesis. Our array-based analyses of… Expand Cationic lipids and polyamines have been used as non-viral gene transfer reagents, both in vitro and in vivo. One of the… Expand Cardiomyocytes are terminally differentiated cells that to date have been characterized as poor targets for nonviral gene… Expand Transfection efficiency of the novel reagent metafectene has not been compared with that of lipofectamine in the published… Expand", "domain": "chemistry", "round": 3} +{"url": "https://rd.springer.com/article/10.1007/s10600-014-1135-1", "date": "2018-08-15T07:00:33Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-34/segments/1534221209980.13/warc/CC-MAIN-20180815063517-20180815083517-00480.warc.gz", "language_score": 0.7075051665306091, "token_count": 935, "dump": "CC-MAIN-2018-34", "global_id": "webtext-fineweb__CC-MAIN-2018-34__0__81133618", "lang": "en", "text": "Chemical Constituents of the Roots of Trichosanthes kirilowii\nThe genus Trichosanthes Linn. (Cucurbitaceae) is composed of about 50 species distributed mainly in Southeast Asia. In traditional Chinese medicine the roots of Trichosanthes kirilowii Maxim., commonly known as “Tian Hua Fen,” are used for the treatment of cough, inflammation, polydipsia, and diabetes . Most previous phytochemical studies of T. kirilowii have focused on the fruits and seeds, and triterpenoids, sterols, amino acid, lipids, and other compounds have been isolated from different parts of the plant [2, 3, 4, 5].\nIn our research on chemical constituents of the roots of T. kirilowii, which has rarely been reported in recent years, 18 compounds were isolated and elucidated as 2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid (1), allantoin (2), nicotinic acid (3), xanthine (4), adenine (5), uracil (6), thymine (7), guanosine (8), uridine (9), phenylalanine (10), tyrosine (11), 1-C-(p-hydroxyphenyl)-glycerol (12), furoic acid (13), p-hydroxybenzoic acid (14), p-hyd...\nKeywordsEtOAc Succinic Acid White Powder Allantoin White Needle\nThis work was financially supported by Tianjin Science and Technology Plan Project (10ZCKFSY09100), Project of New Drug Discovery Platform (2011ZX09201-201-21), and Program from National Natural Science Foundation of China (81125024).\n- 1.National Commission of Chinese Pharmacopoeia, Pharmacopoeia of the People’s Republic of China, Vol. 1, China Medical Science and Technology Press, Beijing, 2010, 52 pp.Google Scholar\n- 5.X. Y. Sun, H. H. Wu, A. Z. Fu, and P. Zhang, Acta Pharm. Sin., 47, 922 (2012).Google Scholar\n- 6.J. P. Peng, Y. Q. Qiao, and X. S. Yao, Chin. J. Med. Chem., 5, 134 (1995).Google Scholar\n- 8.L. Shen, S. J. Dai, and D. Z. Zhao, China J. Chin. Mater. Med., 32, 39 (2007).Google Scholar\n- 11.D. Y. Shi, L. J. Han, J. Sun, Y. Wang, Y. C. Yang, J. G. Shi, and X. Fan, China J. Chin. Mater. Med., 30, 347 (2005).Google Scholar\n- 12.L. Jia, H. F. Li, and L. L. Jing, Chin. Trad. Herb. Drugs, 41, 1771 (2010).Google Scholar\n- 13.K. C. Jang, J. H. Lee, S. C. Kim, E. Y. Song, N. Y. Ro, D. Y. Moon, Y. C. Um, and K. H. Park, J. Appl. Biol. Chem., 50, 17 (2007).Google Scholar\n- 15.J. X. Zheng, N. L. Wang, H. F. Chen, and X. S. Yao, Chin. J. Med. Chem., 17, 302 (2007).Google Scholar\n- 16.H. Y. Zhou, H. Zhang, and S. M. Li, China J. Chin. Mater. Med., 30, 1933 (2005).Google Scholar\n- 17.Z. L. Yang, Y. J. Wei, and W. C. Ye, Chin. Trad. Pat. Med., 25, 228 (2003).Google Scholar\n- 18.X. Y. Xie, Y. F. Su, X. Chai, W. Y. Zhou, X. J. Deng, L. P. Guo, X. M. Gao, and B. L. Zhang, Chin. Trad. Herb. Drugs, 40, 1715 (2009).Google Scholar", "domain": "chemistry", "round": 3} +{"url": "https://www.myotcstore.com/store/p/7798-Chapstick-Lip-Balm-Spf-4-Cherry-Flavor-0-15-Oz-Ea-24-Pack", "date": "2020-02-21T07:20:51Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-10/segments/1581875145443.63/warc/CC-MAIN-20200221045555-20200221075555-00536.warc.gz", "language_score": 0.7316691875457764, "token_count": 252, "dump": "CC-MAIN-2020-10", "global_id": "webtext-fineweb__CC-MAIN-2020-10__0__75210271", "lang": "en", "text": "MANUFACTURER: WYETH CONSUMER.\nINDICATIONS: Chapstick Lip Balm Spf 4, Cherry Flavor\nChapstick Lip Balm temporarily protects chafed, chapped, cracked, or windburned lips. Helps prevent sunburn. Higher SPF gives more sunburn protection.\nContains: Padimate O, White Petrolatum 44% (Skin Protectant).\nArachadyl Propionate, Camphor, Cetyl Alcohol, D&C Red 6 Barium Lake, Fragrance, Isopropyl Lanolate, Isopropyl Myristate, Lanolin, Light Mineral Oil, Menthol, Methylparaben, Octyldodecanol, Phenyl Methicone, Propylparaben, Saccharin, Waxes.\nApply liberally before sun exposure and as needed. Children under 6 months of age: ask a doctor.\nFor external use only. When using this product keep out of eyes. Rinse with water to remove. Stop use and ask a doctor if rash or irritation develops and lasts. Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away.", "domain": "chemistry", "round": 3} +{"url": "https://thrivewellnessnow.com/nad-iv-longevity-therapy/", "date": "2022-09-26T13:24:26Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-40/segments/1664030334871.54/warc/CC-MAIN-20220926113251-20220926143251-00577.warc.gz", "language_score": 0.9282834529876709, "token_count": 893, "dump": "CC-MAIN-2022-40", "global_id": "webtext-fineweb__CC-MAIN-2022-40__0__265438812", "lang": "en", "text": "NAD has been shown to contribute to the following health benefits:\n• Anti-aging at a cellular level\n• Restores cellular energy, mitochondrial dysfunction\n• DNA repair and protection\n• Increased exercise performance and stamina\n• Cognition and memory support; brain health\n• Chronic Illnesses\n• Neurodegenerative Diseases\n• Autoimmune Diseases\n• Drug Addiction and Detox\n• Depression and Anxiety\n• PTSD and Chronic Stress\n• Metabolic Syndrome\nKnown as NAD+ Longevity Therapy or NAD+ Brain Restoration Therapy, NAD is the acronym for nicotinamide adenine dinucleotide – a derivative of Vitamin B3. Found in virtually all living cells, NAD+ Longevity Therapy is essential to sustaining life. A fascinating aspect of NAD+ is its dual role in protecting against factors that age us. This includes mitigating chemical stress, environmental toxins, inflammation, DNA damage, and failing mitochondria (powerhouse of our cells.) At the same time, NAD+ also promotes longevity by facilitating DNA repair and providing cellular benefits associated with caloric restriction and exercise. NAD is also necessary for the production of a group of proteins called “Sirtuins” which play a key role in aging, cell death, stress resistance, inflammation, energy efficiency, and mitochondrial biogenesis (creation of more powerhouse cells.)\nNAD+ AND AGING:\nNAD+ levels markedly decline with age, creating an energy deficit that decreases the\nbody’s ability to retain youthful, healthy function. As we age our NAD+ levels significantly decrease and in advanced age, they plummet to near zero. To give you an idea how impactful NAD+ IV Longevity Therapy can be, by age 50 a typical person may have only half the NAD+ they did in youth and by age 80, they will only have about 1% of NAD reserves. The rigors of modern day life are also taking a toll on our NAD levels. Even at a younger age, we are seeing NAD Deficiency caused by stress, inflammation, diet, alcohol, and drug use, including prescription drugs. Deficiency of NAD+ predisposes us to accelerated aging and impedes our ability to fully benefit from nutrients, resveratrol and other important antioxidants that protect our cells from aging and disease. NAD plays such crucial roles in aging that one day normal aging may be classified as “NAD+ deficiency syndrome.”\nNAD+ AND CHRONIC ILLNESS:\nNAD deficiency has also shown to have direct correlation with chronic illness. Low NAD levels result in low levels of cellular energy, which is one of the primary factors of “mitochondrial dysfunction” – a condition that is implicated in a wide variety of chronic illnesses, including diabetes, autoimmune disorders, multiple sclerosis, and many more. Restoring NAD+ levels allows cells to return to full energy status, offering a possible way to undo mitochondrial damage and the resulting chronic illness.\nNAD+ AND BRAIN HEALTH:\nOne of the most impacted organs from NAD+ deficiency is the brain. NAD+ plays a vital role in the brain by mediating brain aging and the tissue damage caused by various brain illnesses. NAD+ helps to replenish the supply of neurotransmitters, improve cognitive functioning, withdraw from addictive substances, overcome anxiety, depression, chronic or acute stress, post-traumatic stress, CTE, and other conditions by giving the brain what it needs to return to proper functioning. NAD+ has been shown to be effective with cases of brain fog, cognitive impairment, and “chemo brain”. It has a powerful capacity to “reset” the brain to its original set point.\nUsing a direct IV infusion of pure compounded NAD+ from an FDA-registered pharmacy is the most effective and efficient way of raising NAD+ levels. As NAD+ gains popularity in the press and throughout the medical community, there are an increasing number of oral NAD supplements available. However, oral supplements are not regulated and not very effective at raising NAD levels.\nNAD+ Therapy & Ketamine IV Therapy\nCombination Treatment for Mental Health and Overall Improved Quality of Life\nBy improving connections and messaging in the brain, we look at ketamine as a form of liquid ambition and a way to improve people’s perspective on life.", "domain": "chemistry", "round": 3} +{"url": "https://www.onepetro.org/journal-paper/SPE-177057-PA", "date": "2019-07-23T11:25:18Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-30/segments/1563195529276.65/warc/CC-MAIN-20190723105707-20190723131707-00211.warc.gz", "language_score": 0.7429239153862, "token_count": 3302, "dump": "CC-MAIN-2019-30", "global_id": "webtext-fineweb__CC-MAIN-2019-30__0__209991078", "lang": "en", "text": "Wettability Alteration and Spontaneous Imbibition in Unconventional Liquid Reservoirs by Surfactant Additives\n- Johannes O. Alvarez (Texas A&M University) | David S. Schechter (Texas A&M University)\n- Document ID\n- Society of Petroleum Engineers\n- SPE Reservoir Evaluation & Engineering\n- Publication Date\n- February 2017\n- Document Type\n- Journal Paper\n- 107 - 117\n- 2017.Society of Petroleum Engineers\n- Surfactants, Wettability Alteration, Spontaneous Imbibition, Unconventional Liquid Reservoirs, Computed Tomography\n- 24 in the last 30 days\n- 1,242 since 2007\n- Show more detail\n- View rights & permissions\n|SPE Member Price:||USD 10.00|\n|SPE Non-Member Price:||USD 30.00|\nWettability alteration in unconventional liquid reservoirs (ULRs) can improve fracture-treatment performance and consequently oil recovery by changing capillary forces when shifting intermediate and oil-wet reservoirs to water-wet. Wettability can be modified while fracturing the formation by adding surfactants, in proper concentrations, to completion fluids favoring the process of imbibition and increasing current ULR recovery factors of less than 10% of the original oil in place (OOIP). This study combines the effect of wettability and interfacial-tension (IFT) alteration by surfactants and the corresponding effect on spontaneous imbibition in ULRs from the Permian Basin through a correlated experimental work flow, which includes conducting contact-angle (CA) and ζ-potential experiments, IFT measurements, and spontaneous-imbibition experiments combined with computed-tomography (CT) methods to evaluate and compare the efficiency of different surfactants in altering wettability and recovering hydrocarbons from siliceous core at reservoir temperature.\nWettability-experiment results showed that all surfactants change ULR core-wetting affinity from oil- and intermediate-wet to water-wet at commonly field-used concentrations. However, the anionic surfactant showed better results in changing CAs. In addition, the anionic surfactant better reduced the IFT than nonionic and mixed surfactants, and surfactants performed better than fracturing fluid without surfactant additives. Finally, spontaneous-imbibition results showed that the anionic surfactant was better for recovering oil from shale core, which agrees qualitatively with the previous results where the anionic surfactant showed the lowest CAs and IFT. However, both anionic and nonionic surfactants were better in displacing liquid hydrocarbons and had higher penetration magnitudes obtained by CT methods compared with fracturing water without surfactant. From the results obtained, it can be concluded that the addition of proper surfactants to fracturing fluids has the potential of improving oil recovery by wettability and IFT alteration, with the anionic surfactant showing lower CAs and IFT, better imbibition, and higher oil recovery than nonionic and mixed surfactants in these siliceous ULRs from the Permian Basin.\n|File Size||994 KB||Number of Pages||11|\nAdibhatla, B. and Mohanty, K. K. 2008. Oil Recovery from Fractured Carbonates by Surfactant-Aided Gravity Drainage: Laboratory Experiments and Mechanistic Simulations. SPE Res Eval & Eng 11 (1): 119–130. SPE-99773-PA. http://dx.doi.org/10.2118/99773-PA.\nAlharthy, N., Teklu, T., Kazemi, H. et al. 2015. Enhanced Oil Recovery in Liquid-Rich Shale Reservoirs: Laboratory to Field. Presented at the SPE Annual Technical Conference and Exhibition, Houston, 28–30 September. SPE-175034-MS. http://dx.doi.org/10.2118/175034-MS.\nAlvarez, J. O., Neog, A., Jais, A. et al. 2014. Impact of Surfactants for Wettability Alteration in Stimulation Fluids and the Potential for Surfactant EOR in Unconventional Liquid Reservoirs. Presented at the SPE Unconventional Resources Conference, The Woodlands, Texas, 1–3 April. SPE-169001-MS. http://dx.doi.org/10.2118/169001-MS.\nAlvarez, J. O. and Schechter, D.S. 2016. Altering Wettability in Bakken Shale by Surfactant Additives and Potential of Improving Oil Recovery During Injection of Completion Fluids.. Paper presented at SPE Improved Oil Recovery Conference, 11–13 April, Tulsa, Oklahoma. SPE-179688-MS. http://dx.doi.org/10.2118/179688-MS.\nAnderson, W. G. 1986a. Wettability Literature Survey–Part 1: Rock/Oil/Brine Interactions and the Effects of Core Handling on Wettability. J Pet Technol 38 (10): 1125–1144. SPE-13932-PA. http://dx.doi.org/10.2118/13932-PA.\nAnderson, W. G. 1986b. Wettability Literature Survey–Part 2: Wettability Measurement. J Pet Technol 38 (11): 1246–1262. SPE-13933-PA. http://dx.doi.org/10.2118/13933-PA.\nAnderson, W. G. 1987. Wettability Literature Survey–Part 4: Effects of Wettability on Capillary Pressure. J Pet Technol 39 (10): 1283–1300. SPE-15271-PA. http://dx.doi.org/10.2118/15271-PA.\nAustad, T. and Milter, J. 1997. Spontaneous Imbibition of Water into Low Permeable Chalk at Different Wettabilities Using Surfactants. Presented at the International Symposium on Oilfield Chemistry, Houston, 18–21 February. SPE-37236-MS. http://dx.doi.org/10.2118/37236-MS.\nAustad, T., Matre, B., Milter, J. et al. 1998. Chemical Flooding of Oil Reservoirs 8. Spontaneous Oil Expulsion from Oil- and Water-Wet Low Permeable Chalk Material by Imbibition of Aqueous Surfactant Solutions. Colloid. Surface. A 137 (1–3): 117–129. http://dx.doi.org/10.1016/S0927-7757(97)00378-6.\nBabadagli, T., Al-Bemani, A., and Boukadi, F. 1999. Analysis of Capillary Imbibition Recovery Considering the Simultaneous Effects of Gravity, Low IFT, and Boundary Conditions. Presented at the SPE Asia Pacific Improved Oil Recovery Conference, Kuala Lumpur, 25–26 October. SPE-57321-MS. http://dx.doi.org/10.2118/57321-MS.\nBuckley, J. S., Liu, Y. and Monsterleet, S. 1998. Mechanisms of Wetting Alteration by Crude Oils. SPE J. 3 (1): 54–61. SPE-37230-PA. http://dx.doi.org/10.2118/37230-PA.\nChen, H. L., Lucas, L. R., Nogaret, L. A. D. et al. 2001. Laboratory Monitoring of Surfactant Imbibition with Computerized Tomography. SPE Res Eval & Eng 4 (1): 16–25. SPE-69197-PA. http://dx.doi.org/10.2118/69197-PA.\nCraig, F. F. Jr. 1971. Reservoir Engineering Aspects of Waterflooding, Vol. 3. Richardson, Texas: Society of Petroleum Engineers.\nDataPhysics Instruments GmbH. 2016. (http://www.dataphysics.de/2/start/products/software-modules/).\nDoman, L. 2015. US Remained World’s Largest Producer of Petroleum and Natural Gas Hydrocarbons in 2014. US Energy Information Administration, April 2015.\nDowns, H. H. and Hoover, P. D. 1989. Enhanced Oil Recovery by Wettability Alteration. In Oil-Field Chemistry: Enhanced Recovery and Production Stimulation, ed. J. K. Borchardt and T. F. Yen, Chap. 3, 577–595. Washington, DC: American Chemical Society.\nGupta, R. and Mohanty, K. K. 2011. Wettability Alteration Mechanism for Oil Recovery from Fractured Carbonate Rocks. Transport Porous Med. 87 (2): 635–652. http://dx.doi.org/10.1007/s11242-010-9706-5.\nHirasaki, G. J. 1991. Wettability: Fundamentals and Surface Forces. SPE Form Eval 6 (2): 217–226. SPE-17367-PA. http://dx.doi.org/10.2118/17367-PA.\nHirasaki, G. and Zhang, D. L. 2004. Surface Chemistry of Oil Recovery from Fractured, Oil-Wet, Carbonate Formations. SPE J. 9 (2): 151–162. SPE-88365-PA. http://dx.doi.org/10.2118/88365-PA.\nKao, R. L., Wasan, D. T., Nikolov, A. D. et al. 1988. Mechanisms of Oil Removal from a Solid Surface in the Presence of Anionic Micellar Solutions. Colloid. Surface. 34 (4): 389–398. http://dx.doi.org/10.1016/0166-6622(88)80163-X.\nKathel, P. and Mohanty, K. K. 2013. EOR in Tight Oil Reservoirs through Wettability Alteration. Presented at the SPE Annual Technical Conference and Exhibition, New Orleans, 30 September–2 October. SPE-166281-MS. http://dx.doi.org/10.2118/166281-MS.\nKumar, K., Dao, E. K. and Mohanty, K. K. 2008. Atomic Force Microscopy Study of Wettability Alteration by Surfactants. SPE J. 13 (2): 137–145. SPE-93009-PA. http://dx.doi.org/10.2118/93009-PA.\nLeslie, Z. D., Liu, S., Puerto, M. et al. 2006. Wettability Alteration and Spontaneous Imbibition in Oil-Wet Carbonate Formations. J. Pet. Sci. Eng. 52 (1–4): 213–226. http://dx.doi.org/10.1016/j.petrol.2006.03.009.\nMorsy, S. and Sheng, J. J. 2014. Surfactant Preflood to Improve Waterflooding Performance in Shale Formations. Presented at the SPE Western North American and Rocky Mountain Joint Meeting, Denver, 17–18 April. SPE-169519-MS. http://dx.doi.org/10.2118/169519-MS.\nNguyen, D., Wang, D., Oladapo, A. et al. 2014. Evaluation of Surfactants for Oil Recovery Potential in Shale Reservoirs. Presented at the SPE Improved Oil Recovery Symposium, Tulsa, 12–16 April. SPE-169085-MS. http://dx.doi.org/10.2118/169085-MS.\nOdusina, E. O., Sondergeld, C. H. and Rai, C. S. 2011. NMR Study of Shale Wettability. Presented at the Canadian Unconventional Resources Conference, Calgary, 15–17 November. SPE-147371-MS. http://dx.doi.org/10.2118/147371-MS.\nSalehi, M., Johnson, S. J. and Liang, J.-T. 2008. Mechanistic Study of Wettability Alteration Using Surfactants with Applications in Naturally Fractured Reservoirs. Langmuir 24 (24): 14099–14107. http://dx.doi.org/10.1021/la802464u.\nSchneider, C. A., Rasband, W. S. and Eliceiri, K. W. 2012. NIH Image to ImageJ: 25 years of image analysis. Nature Methods 9 (7): 671–675. PMID 22930834.\nShuler, P. J., Tang, H., Lu, Z. et al. 2011. Chemical Process for Improved Oil Recovery from Bakken Shale. Presented at the Canadian Unconventional Resources Conference, Calgary, 15–17 November. SPE-147531-MS. http://dx.doi.org/10.2118/147531-MS.\nStandnes, D. C. and Austad, T. 2000. Wettability Alteration in Chalk: 2. Mechanism for Wettability Alteration from Oil-Wet to Water-Wet Using Surfactants. J. Pet. Sci. Eng. 28 (3): 123–143. http://dx.doi.org/10.1016/S0920-4105(00)00084-X.\nStandnes, D. C. 2001. Enhanced Oil Recovery from Oil-Wet Carbonate Rock by Spntaneous Imbibition of Aqueous Surfactant Solutions. PhD dissertation, Norwegian University of Science and Technology, Trondheim, Norway.\nWang, D., Butler, R., Zhang, J. et al. 2012. Wettability Survey in Bakken Shale with Surfactant-Formulation Imbibition. SPE Res Eval & Eng 15 (6): 695–705. SPE-153853-PA. http://dx.doi.org/10.2118/153853-PA.\nWang, D., Zhang, J., Butler, R. et al. 2015. Scaling Laboratory Data Surfactant Imbibition Rates to the Field in Fractured Shale Formations. Presented at the Unconventional Resources Technology Conference, San Antonio, Texas, 20–22 July. SPE-178489-MS. http://dx.doi.org/10.2118/178489-MS.\nZhang, P. and Austad, T. 2005. Waterflooding in Chalk: Relationship Between Oil Recovery, New Wettability Index, Brine Composition and Cationic Wettability Modifier. Presented at the SPE Europec/EAGE Annual Conference, Madrid, Spain, 1316 June. SPE-94209-MS. http://dx.doi.org/10.2118/94209-MS.", "domain": "chemistry", "round": 3} +{"url": "http://www.diabeteshealthstudy.com/130-fasting-blood.html", "date": "2022-09-30T13:57:38Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-40/segments/1664030335469.40/warc/CC-MAIN-20220930113830-20220930143830-00351.warc.gz", "language_score": 0.9147212505340576, "token_count": 300, "dump": "CC-MAIN-2022-40", "global_id": "webtext-fineweb__CC-MAIN-2022-40__0__139209525", "lang": "en", "text": "Common questions and answers about fasting blood glucose blood sugar level. Normal fasting blood sugar ranges from 70 to 99 mg/dl; learn all normal fasting blood sugar levels (and blood sugar levels after eating) which indicate pre-diabetes. Fasting blood glucose: a test to determine how much glucose (sugar) is in a blood sample after an overnight fast. the fasting blood glucose test is commonly used to.\nHi, i am worried about my fasting glucose reading 135. i started to take glucophage xr (metformin) 750mg during night since 3 months. there is no change in my fasting. Is the blood sugar of 130 too high? normal levels are between 70-100!levels between 100-125 suggest prediabetes and levels of 126 or more is consistent with diabetes!. I was diagnosied with type ii diabetes 2 years ago. i am having a wide variance in the fasting blood sugar results each morning. if i test just as soon as i get up my.\nRandom vs. fasting blood glucose tests. diabetes is a disease in which levels of glucose, a type of sugar, are abnormally high in the body. glucose tests. Fasting blood sugar levels chart monitoring the blood glucose levels helps you with both diagnosis and control of diabetes. the following article provides a chart.\nThe blood sugar concentration or blood glucose level is the amount of glucose (sugar) present in the blood of a human or animal. the body naturally tightly regulates.", "domain": "chemistry", "round": 3} +{"url": "https://www.creative-diagnostics.com/Anti-CEA-MAb-coating-175684-490.htm", "date": "2018-09-20T12:15:29Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-39/segments/1537267156471.4/warc/CC-MAIN-20180920120835-20180920141235-00527.warc.gz", "language_score": 0.7491380572319031, "token_count": 306, "dump": "CC-MAIN-2018-39", "global_id": "webtext-fineweb__CC-MAIN-2018-39__0__153280976", "lang": "en", "text": "Anti-Carcinoembryonic antigen monoclonal antibody (DCABH-20068)\nMouse Anti-Human Carcinoembryonic antigen monoclonal antibody for ELISA, CLIA, RIA, IHC, WB\nBring this labeled antibody directly to your bench!\nOnline Inquiry Add to basket\nCEA isolated from colorectal carcinomas by PCA extraction.\nHave you cited DCABH-20068 in a publication? Let us know\nand earn a reward for your research.\nChen, JS; Chen, KT; et al. Comparison of membrane fraction proteomic profiles of normal and cancerous human colorectal tissues with gel-assisted digestion and iTRAQ labeling mass spectrometry. FEBS JOURNAL 277:3028-3038(2010).\nBartlett, JMS; Thomas, J; et al. Mammostrat (R) as a tool to stratify breast cancer patients at risk of recurrence during endocrine therapy. BREAST CANCER RESEARCH 12:-(2010).\nCustom Antibody Labeling\nWe offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody.", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/tnf-receptor-i-antibody-ab134562.html", "date": "2020-08-04T05:25:37Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-34/segments/1596439735860.28/warc/CC-MAIN-20200804043709-20200804073709-00439.warc.gz", "language_score": 0.7512830495834351, "token_count": 890, "dump": "CC-MAIN-2020-34", "global_id": "webtext-fineweb__CC-MAIN-2020-34__0__55683780", "lang": "en", "text": "Key features and details\n- Goat polyclonal to TNF Receptor I\n- Suitable for: WB\n- Reacts with: Human\n- Isotype: IgG\nProduct nameAnti-TNF Receptor I antibody\nSee all TNF Receptor I primary antibodies\nDescriptionGoat polyclonal to TNF Receptor I\nTested applicationsSuitable for: WBmore details\nSpecies reactivityReacts with: Human\nPredicted to work with: Rat, Cat, Dog, Pig, Cynomolgus monkey, Rhesus monkey\n- WB: Human Lung lysate, A549, HepG2, K562\nStorage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.\nStorage bufferpH: 7.30\nPreservative: 0.02% Sodium azide\nConstituents: 99% Tris buffered saline, 0.5% BSA\nConcentration information loading...\nPurityImmunogen affinity purified\nPurification notesPurified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.\nOur Abpromise guarantee covers the use of ab134562 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\n|WB||Use a concentration of 0.3 - 1 µg/ml. Predicted molecular weight: 50 kDa.\n1 hour primary incubation is recommended for this product.\nFunctionReceptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.\nInvolvement in diseaseFamilial hibernian fever\nMultiple sclerosis 5\nSequence similaritiesContains 1 death domain.\nContains 4 TNFR-Cys repeats.\nDomainThe domain that induces A-SMASE is probably identical to the death domain. The N-SMASE activation domain (NSD) is both necessary and sufficient for activation of N-SMASE.\nBoth the cytoplasmic membrane-proximal region and the C-terminal region containing the death domain are involved in the interaction with TRPC4AP.\nmodificationsThe soluble form is produced from the membrane form by proteolytic processing.\nCellular localizationCell membrane. Golgi apparatus membrane. Secreted. A secreted form is produced through proteolytic processing and Secreted. Lacks a Golgi-retention motif, is not membrane bound and therefore is secreted.\n- Information by UniProt\n- CD120a antibody\n- FPF antibody\n- MGC19588 antibody\nAll lanes : Anti-TNF Receptor I antibody (ab134562) at 0.5 µg/ml\nLane 1 : A549 (Human lung carcinoma)\nLane 2 : HepG2 (Human liver hepatocellular carcinoma)\nLane 3 : K562 (Human chronic myelogenous leukemia cells from bone marrow)\nLysates/proteins at 35 µg per lane.\nPredicted band size: 50 kDa\nPrimary incubation was 1 hour. Detected by chemiluminescence.\nAnti-TNF Receptor I antibody (ab134562) at 0.3 µg/ml + Human Lung lysate (in RIPA buffer) at 35 µg\nDeveloped using the ECL technique.\nPredicted band size: 50 kDa\nObserved band size: 52 kDa why is the actual band size different from the predicted?\nab134562 has not yet been referenced specifically in any publications.", "domain": "chemistry", "round": 3} +{"url": "http://pubmedcentralcanada.ca/pmcc/articles/PMC359764/?lang=en-ca", "date": "2017-07-26T02:14:20Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-30/segments/1500549425737.60/warc/CC-MAIN-20170726002333-20170726022333-00257.warc.gz", "language_score": 0.9095696210861206, "token_count": 424, "dump": "CC-MAIN-2017-30", "global_id": "webtext-fineweb__CC-MAIN-2017-30__0__59244295", "lang": "en", "text": "|Home | About | Journals | Submit | Contact Us | Français|\nA Saccharomyces cerevisiae lambda gt11 library was screened with antiphosphotyrosine antibodies in an attempt to identify a gene encoding a tyrosine kinase. A subclone derived from one positive phage was sequenced and found to contain an 821-amino-acid open reading frame that encodes a protein with homology to protein kinases. We tested the activity of the putative kinase by constructing a vector encoding a glutathione-S-transferase fusion protein containing most of the predicted polypeptide. The fusion protein phosphorylated endogenous substrates and enolase primarily on serine and threonine. The gene was designated SPK1 for serine-protein kinase. Expression of the Spk1 fusion protein in bacteria stimulated serine, threonine, and tyrosine phosphorylation of bacterial proteins. These results, combined with the antiphosphotyrosine immunoreactivity induced by the kinase, indicate that Spk1 is capable of phosphorylating tyrosine as well as phosphorylating serine and threonine. In in vitro assays, the fusion protein kinase phosphorylated the synthetic substrate poly(Glu/Tyr) on tyrosine, but the activity was weak compared with serine and threonine phosphorylation of other substrates. To determine if other serine/threonine kinases would phosphorylate poly(Glu/Tyr), we tested calcium/calmodulin-dependent protein kinase II and the catalytic subunit of cyclic AMP-dependent protein kinase. The two kinases had similar tyrosine-phosphorylating activities. These results establish that the functional difference between serine/threonine- and tyrosine-protein kinases is not absolute and suggest that there may be physiological circumstances in which tyrosine phosphorylation is mediated by serine/threonine kinases.", "domain": "chemistry", "round": 3} +{"url": "https://www.altumtechnologies.com/industries/chemical-production/", "date": "2021-05-18T11:37:52Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-21/segments/1620243989819.92/warc/CC-MAIN-20210518094809-20210518124809-00214.warc.gz", "language_score": 0.9301162958145142, "token_count": 473, "dump": "CC-MAIN-2021-21", "global_id": "webtext-fineweb__CC-MAIN-2021-21__0__35550411", "lang": "en", "text": "Pipelines, valves, reactors and heat exchangers are standard equipment of the chemical industry that gets fouled continuously. There are hundreds of different substances that cause fouling, depending on the chemicals used. Fouling in the equipment can be elastic or inelastic, porous or solid. Due to the differences in fouling types, the cleaning process of fouled equipment is troublesome, and it requires a lengthy stoppage for cleaning. As a result, chemical plants are losing precious production time.\nTo minimize the process stoppage for fouling removal, chemical plants have been actively searching for fouling prevention methods. This can be implemented by applying a coating to the inner wall of equipment, for instance. Another common method to reduce fouling is to slightly change the process environment (e.g. pressure, humidity, temperature). However, such approaches do not always lead to a drastic improvement of the fouling situation. In the worst case, these methods may even present negative impacts on the final product.\nWhen the above-mentioned fouling prevention methods are not demonstrating any results, it is natural to choose a more optimal solution that can both remove and prevent fouling without stopping the production or changing its process.\nBenefits of using Altum's software-guided power ultrasound\n- It provides more uptime by reducing the total time and frequency of maintenance stoppages.\n- It does not require the dismantling of fouled equipment.\n- It is an environment-friendly solution that provides a safer work environment for the site workers as no chemicals are used or required for fouling removal.\n- It can reduce the overall maintenance cost as power ultrasound does not affect the durability of equipment, unlike high-pressure water jet cleaning, for example, which significantly increases the risk of corrosion for the equipment.\nIn a large chemical plant, stopping the production process for a day may cause a loss of several hundreds of thousands or even up to millions. Altum's software guided power ultrasound is an optimal solution for this issue as it has a short payback against investment. Altum's fouling prevention method consumes less energy and reduces CO2 emission.\nRequest a Quote\nWe would love to hear more about your case. Our engineers can analyse it and provide you with the best way to solve it. Please don't hesitate to contact us using the form below.", "domain": "chemistry", "round": 3} +{"url": "https://www.e3s-conferences.org/articles/e3sconf/abs/2020/49/e3sconf_astfe2020_02003/e3sconf_astfe2020_02003.html", "date": "2020-09-30T10:49:51Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-40/segments/1600402123173.74/warc/CC-MAIN-20200930075754-20200930105754-00049.warc.gz", "language_score": 0.852527916431427, "token_count": 384, "dump": "CC-MAIN-2020-40", "global_id": "webtext-fineweb__CC-MAIN-2020-40__0__168586484", "lang": "en", "text": "E3S Web Conf.\nVolume 189, 20202020 International Conference on Agricultural Science and Technology and Food Engineering (ASTFE 2020)\n|Number of page(s)||4|\n|Section||Food Biochemistry and Food Processing|\n|Published online||15 September 2020|\nDetection of Urethane in Non-alcoholic Fermented Food\nChiFeng Indusrty Vocational Technology College, Inner Mongolia, 024005\nAmong fermented foods, urethane often appears, which is a “2A” grade carcinogen. There are many types of fermented foods in my country, and the detection methods are not uniform enough, and no specific urethane detection standards have been formed. This article summarizes the specific experiments and results analysis based on previous work experience. At the same time, this article discusses six aspects from thin layer analysis, gas chromatography, gas chromatography-mass spectrometry, two-dimensional live multidimensional gas chromatography with stable isotope labeling mass spectrometry, high performance liquid chromatography-fluorescence, and nuclear magnetic resonance detection. The detection method of urethane in non-alcoholic fermented foods is introduced.\n© The Authors, published by EDP Sciences, 2020\nThis is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.\nCurrent usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.\nData correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.\nInitial download of the metrics may take a while.", "domain": "chemistry", "round": 3} +{"url": "https://www.accessscience.com/content/Bioleaching/082525", "date": "2019-03-26T07:54:46Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-13/segments/1552912204885.27/warc/CC-MAIN-20190326075019-20190326101019-00281.warc.gz", "language_score": 0.8458344340324402, "token_count": 444, "dump": "CC-MAIN-2019-13", "global_id": "webtext-fineweb__CC-MAIN-2019-13__0__162370736", "lang": "en", "text": "Brierley, Corale L. Brierley Consultancy LLC, Highlands Ranch, Colorado.\n- Bioleaching of Sulfide Minerals\n- Principles of bioleaching\n- Industrial applications of bioleaching\n- Bioleaching of Nonsulfide Minerals\n- Future Developments\n- Links to Primary Literature\n- Additional Readings\nThe use of naturally occurring microorganisms to dissolve metals from minerals. This biotechnical process, involving bacteria, archaea, fungi, and yeast, can be applied to both sulfide and nonsulfide minerals. At present, bioleaching is employed on a large commercial scale to extract metals from sulfide minerals. See also: Hydrometallurgy; Leaching\nThe content above is only an excerpt.\nfor your institution. Subscribe\nTo learn more about subscribing to AccessScience, or to request a no-risk trial of this award-winning scientific reference for your institution, fill in your information and a member of our Sales Team will contact you as soon as possible.\nto your librarian. Recommend\nLet your librarian know about the award-winning gateway to the most trustworthy and accurate scientific information.\nAccessScience provides the most accurate and trustworthy scientific information available.\nRecognized as an award-winning gateway to scientific knowledge, AccessScience is an amazing online resource that contains high-quality reference material written specifically for students. Contributors include more than 9000 highly qualified scientists and 43 Nobel Prize winners.\nMORE THAN 8500 articles and Research Reviews covering all major scientific disciplines and encompassing the McGraw-Hill Encyclopedia of Science & Technology and McGraw-Hill Yearbook of Science & Technology\n115,000-PLUS definitions from the McGraw-Hill Dictionary of Scientific and Technical Terms\n3000 biographies of notable scientific figures\nMORE THAN 19,000 downloadable images and animations illustrating key topics\nENGAGING VIDEOS highlighting the life and work of award-winning scientists\nSUGGESTIONS FOR FURTHER STUDY and additional readings to guide students to deeper understanding and research\nLINKS TO CITABLE LITERATURE help students expand their knowledge using primary sources of information", "domain": "chemistry", "round": 3} +{"url": "http://www.researchgate.net/publication/11304861_Apolipoprotein_CI_deficiency_markedly_augments_plasma_lipoprotein_changes_mediated_by_human_cholesteryl_ester_transfer_protein_(CETP)_in_CETP_transgenicApoCI-knocked_out_mice", "date": "2014-12-21T19:46:09Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2014-52/segments/1418802772265.125/warc/CC-MAIN-20141217075252-00139-ip-10-231-17-201.ec2.internal.warc.gz", "language_score": 0.8949521780014038, "token_count": 1484, "dump": "CC-MAIN-2014-52", "global_id": "webtext-fineweb__CC-MAIN-2014-52__0__203153934", "lang": "en", "text": "Apolipoprotein CI deficiency markedly augments plasma lipoprotein changes mediated by human cholesteryl ester transfer protein (CETP) in CETP transgenic/ApoCI-knocked out mice.\nABSTRACT Transgenic mice expressing human cholesteryl ester transfer protein (HuCETPTg mice) were crossed with apolipoprotein CI-knocked out (apoCI-KO) mice. Although total cholesterol levels tended to be reduced as the result of CETP expression in HuCETPTg heterozygotes compared with C57BL6 control mice (-13%, not significant), a more pronounced decrease (-28%, p < 0.05) was observed when human CETP was expressed in an apoCI-deficient background (HuCETPTg/apoCI-KO mice). Gel permeation chromatography analysis revealed a significant, 6.1-fold rise (p < 0.05) in the cholesteryl ester content of very low density lipoproteins in HuCETPTg/apoCI-KO mice compared with control mice, whereas the 2.7-fold increase in HuCETPTg mice did not reach the significance level in these experiments. Approximately 50% decreases in the cholesteryl ester content and cholesteryl ester to triglyceride ratio of high density lipoproteins (HDL) were observed in HuCETPTg/apoCI-KO mice compared with controls (p < 0.05 in both cases), with intermediate -20% changes in HuCETPTg mice. The cholesteryl ester depletion of HDL was accompanied with a significant reduction in their mean apparent diameter (8.68 +/- 0.04 nm in HuCETPTg/apoCI-KO mice versus 8.83 +/- 0.02 nm in control mice; p < 0.05), again with intermediate values in HuCETPTg mice (8.77 +/- 0.04 nm). In vitro purified apoCI was able to inhibit cholesteryl ester exchange when added to either total plasma or reconstituted HDL-free mixtures, and coincidently, the specific activity of CETP was significantly increased in the apoCI-deficient state (173 +/- 75 pmol/microg/h in HuCETPTg/apoCI-KO mice versus 72 +/- 19 pmol/microg/h in HuCETPTg, p < 0.05). Finally, HDL from apoCI-KO mice were shown to interact more readily with purified CETP than control HDL that differ only by their apoCI content. Overall, the present observations provide direct support for a potent specific inhibition of CETP by plasma apoCI in vivo.\n- SourceAvailable from: John-Bjarne Hansen[Show abstract] [Hide abstract]\nABSTRACT: Background. Experimental studies in animals suggest that apolipoprotein (apo) C-I is an important regulator of triglycerides in fasting and postprandial conditions and associated with carotid atherosclerosis. Methods. A cross-sectional study was conducted with 81 subjects, aged 56-80 years recruited from a population health survey. The participants underwent a fat tolerance test (1 g fat per Kg body weight) and carotid atherosclerosis was determined by ultrasound examination. VLDL particles, Sf 20-400, were isolated and their lipid composition and apoC-I content determined. Results. The carotid plaque area increased linearly with the number of apoC-I molecules per VLDL particles (P = 0.048) under fasting conditions. Fasting triglycerides increased across tertiles of apoC-I per VLDL particle in analyses adjusted for apoC-II and -C-III, apoE genotype and traditional cardiovascular risk factors (P = 0.011). The relation between apoC-I in VLDL and serum triglycerides was conveyed by triglyceride enrichment of VLDL particles (P for trend <0.001. The amount of apoC-I molecules per VLDL was correlated with the total (r = 0.41, P < 0.0001) and incremental (r = 0.35, P < 0.001) area under the postprandial triglyceride curve. Conclusions. Our findings support the concept that the content of apoC-I per VLDL particle is an important regulator of triglyceride metabolism in the fasting and postprandial state and associated with carotid athrosclerosis.Journal of lipids. 01/2011; 2011:271062.\n- [Show abstract] [Hide abstract]\nABSTRACT: Cholesteryl ester transfer protein (CETP) is important clinically and is the current target for new drug development. Its structure and mechanism of action has not been well understood. We have combined current new structural and functional methods to compare with relevant prior data. These analyses have led us to propose several steps in CETP's function at the molecular level, in the context of its interactions with lipoproteins, e.g., sensing, penetration, docking, selectivity, ternary complex formation, lipid transfer, and HDL dissociation. These new molecular insights improve our understanding of CETP's mechanisms of action.The Journal of Lipid Research 06/2012; 53(8):1451-8. · 4.39 Impact Factor\n- [Show abstract] [Hide abstract]\nABSTRACT: Plasma cholesteryl ester transfer protein (CETP) promotes the cholesterol enrichment of apoB-containing lipoproteins (VLDL and LDL) at the expense of HDL. Recent studies demonstrated that apoC1 is a potent CETP inhibitor in plasma of healthy, normolipidemic subjects. Our goal was to establish whether the modulation of CETP activity by apoC1 is influenced by dyslipidemia in patients with documented coronary artery disease (CAD). In the total CAD population studied (n = 240), apoC1 levels correlated negatively with CETP activity, independently of apoE-epsilon, CETP-Taq1B, and apoC1-Hpa1 genotypes. In multivariate analysis, the negative relationship was observed only in normolipidemic patients, not in those with hypercholesterolemia, hypertriglyceridemia, or combined hyperlipidemia. In the normolipidemic subjects, apoC1 levels were positively associated with higher HDL- to LDL-cholesterol ratio (r = 0.359, P < 0.001). It is concluded that apoC1 as a CETP inhibitor no longer operates on cholesterol redistribution in high-risk patients with dyslipidemia, probably due to increasing amounts of VLDL-bound apoC1, which is inactive as a CETP inhibitor. Patients with dyslipidemia could experience major benefits from treatment with pharmacological CETP inhibitors, which might compensate for blunted endogenous inhibition.The Journal of Lipid Research 04/2012; 53(6):1200-9. · 4.39 Impact Factor", "domain": "chemistry", "round": 3} +{"url": "http://www.genetex.com/HPK1-MAP4K1-antibody-N-term-GTX22646.html", "date": "2017-04-26T15:51:45Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-17/segments/1492917121453.27/warc/CC-MAIN-20170423031201-00138-ip-10-145-167-34.ec2.internal.warc.gz", "language_score": 0.777880847454071, "token_count": 295, "dump": "CC-MAIN-2017-17", "global_id": "webtext-fineweb__CC-MAIN-2017-17__0__190093392", "lang": "en", "text": "|Full Name||mitogen-activated protein kinase kinase kinase kinase 1|\n|Product Description||Goat polyclonal antibody to MAP4K1|\n|Background||HPKI (hematopoietic progenitor kinase I) is one of these mammalian kinases that have significant sequence similarity to the Saccharomyces Cerevisiae serine/threonine kinase STE20, which relays signals from G-protein coupled receptors to cytosolic MAP kinase cascades.|\n|Synonyms||hematopoietic progenitor kinase1, mitogen-activated protein kinase kinase kinase kinase 1, MAP4K1, HPK1, mitogenactivated protein kinase kinase kinase kinase1, mitogenactivated protein kinase kinase kinase kinase 1, HPK1 / MAP4K1, hematopoietic progenitor kinase 1|\n|Specificity||This antibody is specific for MAP4K1.|\n|Predicted Cross Reactivity species Predicted cross-reactivity:|\nPredicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.\nPlease note that we are only able to guarantee products to work in applications and species in which they have been tested.\n|Mouse, Rat, Dog, Pig, Bovine|", "domain": "chemistry", "round": 3} +{"url": "http://silane-resin.buy.chinalane.org/pz64cc240-c9-hc-9120-petroleum-hydrocarbon-resin-with-the-property-of-fast-drying.html", "date": "2023-09-30T06:14:38Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233510603.89/warc/CC-MAIN-20230930050118-20230930080118-00626.warc.gz", "language_score": 0.6793273091316223, "token_count": 530, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__223819940", "lang": "en", "text": "Brand Name : Ecopower\nModel Number : HC - 9120\nCertification : ISO 9001\nPlace of Origin : China\nMOQ : Negotiation, MT\nPrice : USD, Price Negotiation\nPayment Terms : L/C, D/A, D/P, T/T\nSupply Ability : 12000 MT/year\nDelivery Time : two weeks after order confirmation\nPackaging Details : 25kg in PE bag or Paper bag\nAppearance : granular solid with the color of yellow\nSoftening Point : 110 - 120℃\nColor Gardner : 3 - 5\nApplication1 : bookbinding\nApplication2 : hot moelt adhesive\nApplication3 : printing ink\nC9 HC - 9120 Petroleum Hydrocarbon Resin With The Property Of Fast Drying Applied In Printing Ink\nProduct Name : C9 Thermal Polymerization Resin\nType : HC - 9120\nHC - 9120 is obtained from C9 craking, through thermal, polymerization. It's a kind of granularsolid with color from yellow to light yellow. It has the properties of good heat stability, intersolubility, viscosity, light stability, water resistance and very good chemical stability over acid and alkali.\n|Test Item||Test Range||Test Method|\n|Appearance||Light Yellow Or Yellow||Eyeballing|\n|Color Gardner||3 - 5||GB12007.1|\n|Softening Point ( ℃ )||110 - 120||GB2294 ( Ring & Ball )|\n|Acid Value ( KOH mg / g )||≤ 1||GB2895|\n|Ash Content ( wt % )||≤ 0.1||GB2295|\nHC-9120 is suitable for coating, bookbinding, printing ink, hot melt adhesive, rubber assistant agent and modified resin etc., and can be supplied what the specification you need.\nPacking and Storage\n1. Packing : 25kg / bag, available for customized.\n2. Storage : Should be stored in low temperature place with good ventilation and avoid direct sunlight.\n3. Shelf life : One year in ventilating, cool and dry area.\nRemarks : Palletized forms of resins may block or lump in hot weather climates or if stored near heat sources. inside storage is recommended and keep at temperature not exceeding 30 degree.\nC9 HC - 9120 Petroleum Hydrocarbon Resin With The Property Of Fast Drying Applied In Printing Ink Images", "domain": "chemistry", "round": 3} +{"url": "https://quiztablet.com/the-hormones-that-regulate-plant-growth-are/", "date": "2022-08-12T05:41:54Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571584.72/warc/CC-MAIN-20220812045352-20220812075352-00622.warc.gz", "language_score": 0.938231885433197, "token_count": 468, "dump": "CC-MAIN-2022-33", "global_id": "webtext-fineweb__CC-MAIN-2022-33__0__11573611", "lang": "en", "text": "The hormones that regulate plant growth are\nA. ethylene and auxins\nB. auxin and gibberellins\nC. cytokinin and abscisic acid\nD. ethylene and gibberellins\nHormones are internal chemical substances which assists living organisms in a specialized function, example of this function is growth in plants. Some hormones inhibit plant growth, while others expedite the same. By regulate, the examiner would mean control and not outright inhibition.\nNow for the right answer to the above question:\n- Ethylene is a plant hormone responsible for drooping and dropping of leaves, it is also responsible for ripening of fruits. Therefore, A is incorrect. Yes, auxins are known plant growth promoters, they promote the development of flowers and roots, but the presence of ethylene, which directly do not contribute to conventional growths renders this option wrong.\n- Yes, gibberellins speed up germination and promote cell division and elongation. In addition to auxins, which have been established as true growth promoters, confirms an answer. B is very correct.\n- Cytokinin is also a hormone known for cell division, a mixture of cytokinin and auxin is used to regulate the development of shoot and root system in plants. However, C is wrong because abscisic acid is a plant hormone which inhibits plant growth rather than promote same. By the term ‘regulate’ in the question, I would assume the examiner meant growth control and not outright inhibition.\n- D is also incorrect; again, ethylene, though also a plant hormone isn’t responsible for conventional growth, but for ripening of fruits, drooping and dropping of leaves.\nYou may please note that:\n- All the above mentioned options are valid plant hormones.\n- Some of these hormones are not responsible for growth, but for some other function such as ripening of fruits, drooping and dropping of leaves, regulation of aging (cytokinin).\nUse the questions and answers session to raise further questions on this topic…\n/ culled from 2017 JAMB-UTME biology question 2 /", "domain": "chemistry", "round": 3} +{"url": "https://iris.univr.it/handle/11562/949576", "date": "2022-12-10T01:51:14Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-49/segments/1669446711637.64/warc/CC-MAIN-20221210005738-20221210035738-00724.warc.gz", "language_score": 0.8976517915725708, "token_count": 635, "dump": "CC-MAIN-2022-49", "global_id": "webtext-fineweb__CC-MAIN-2022-49__0__228804575", "lang": "en", "text": "AIMS: Apolipoprotein C-III (ApoC-III) is well recognized as a main determinant of triglyceride (TG) plasma concentration and plays a crucial role in coronary artery disease (CAD). However, data on ApoC-III glycoforms are only sparse so far. The aim of this study was to quantify ApoC-III glycoforms in CAD patients and to assess their correlations with plasma lipids. METHODS: ApoC-III glycoforms were analysed by mass spectrometry in 55 subjects with clinically stable CAD (90.9% males, mean age 70.2±7.9 years) within the framework of the Verona Heart Study. RESULTS: Three different ApoC-III glycoforms were identified: non-sialylated (ApoC-III0), monosialylated (ApoC-III1), and disialylated isoforms (ApoC-III2). The analyses were performed on the relative proportion of ApoC-III glycoforms. ApoC-III0 correlated negatively with total ApoC-III concentration (R=-0.351;P=0.009), ApoC-III1 had a positive correlation (R=0.382;P=0.004), while ApoC-III2 did not have significant correlation. The different glycoforms showed different pattern of correlations with the other parameters of plasma lipid profile. ApoC-III0 was inversely correlated with TG (R=-0.421;P=0.001), total cholesterol (R=-0.314;P=0.020), LDL cholesterol (R=-0.317;P=0.018), ApoE (R=-0.434;P=0.001), and Apo B (R=-0.292;P=0.030), while ApoC-III1 was directly correlated with TG (R=0.438;P=0.001) ), total cholesterol (R=0.280;P=0.038), LDL cholesterol (R=0.337;P=0.012), ApoE (R=0.457;P=0.001), and ApoB (R=0.288;P=0.033). On the other hand, no significant correlation was found for ApoC-III2. The ApoC-III1/ApoC-III0 ratio was a significant predictor of both TG (β=0.201;P=0.025) and ApoE levels (β=0.270; P=0.016) in linear regression models adjusted for sex, age, and total ApoC-III concentration. CONCLUSIONS: ApoC-III glycoforms have heterogeneous correlations with plasma lipids in CAD patients, suggesting that they could have different metabolic properties and biological activities.\nFile in questo prodotto:\nNon ci sono file associati a questo prodotto.", "domain": "chemistry", "round": 3} +{"url": "https://www.kinesiologyshop.com/biofilms-test-kit", "date": "2024-04-19T12:40:02Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712296817398.21/warc/CC-MAIN-20240419110125-20240419140125-00205.warc.gz", "language_score": 0.9268372058868408, "token_count": 275, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__84212363", "lang": "en", "text": "LWP Biofilms Test Kit\n15 vials, in a white cardboard flat tray box with molded foam inlay for vials\nVial Size: 10 x 50mm\nBiofilms can make bacteria in the body difficult to find and counteract. A biofilm comprises any group of microorganisms in which cells stick to each other and often also to a surface. These adherent cells become embedded within a slimy extracellular matrix that is composed of extracellular polymeric substances (EPS). The cells within the biofilm produce the EPS components, which are typically a polymeric conglomeration of extracellular polysaccharides, proteins, lipids and DNA. Because they have three-dimensional structure and represent a community lifestyle for microorganisms, they have been metaphorically described as \"cities for microbes\".\nDental plaque is a biofilm or mass of bacteria that grows on surfaces within the mouth. It is a sticky colourless deposit at first, but when it forms tartar, it is often brown or pale yellow. For use in energy work by Kinesiologists, Bioresonence Pratitioners etc.\nBe The First To Review This Product!\nHelp other Equilibrium users shop smarter by writing reviews for products you have purchased.", "domain": "chemistry", "round": 3} +{"url": "https://www.intertek.com/pharmaceutical/bioanalysis/GCP-services/", "date": "2024-02-25T19:14:01Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707947474641.34/warc/CC-MAIN-20240225171204-20240225201204-00628.warc.gz", "language_score": 0.8998509645462036, "token_count": 447, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__45371941", "lang": "en", "text": "Good Clinical Practice (GCP) compliant bioanalytical laboratory services (UK) supporting human clinical trials in compliance with UK and EU legislation\nIntertek's GCP bioanalysis services strive to ensure that Good Clinical Practice (GCP) compliant bioanalytical methods are applied to the analysis of study samples for human clinical trials, as described in the European Medicines Agency (EMA) 2012 Guidance.\nGCP is a set of internationally recognized, ethical and scientific quality requirements which must be observed for designing, conducting, recording and reporting clinical trials that involve the participation of human subjects (EU Directive 2001/20/EC, article 1, clause 2). A bioanalytical CRO would require an understanding of the applicable GCPs in order to identify the impact of deviations from a clinical (non-GLP) bioanalytical study or clinical protocol.\nOur GCP compliant bioanalytical laboratory conducts human clinical trial sample bioanalysis following the principles of GCP and our staff are fully trained on the GCP expectations associated with clinical sample integrity, respective data integrity and communications, patient safety and confidentially requirements. Our bioanalysis laboratories offer both GCP and Good Laboratory Practice (GLP) bioanalysis contract services to support preclinical and clinical development for a range of product types including small molecule pharmaceuticals, proteins and PEGylated products. GCP bioanalysis services are available across a wide range of bioanalytical technologies, and delivered via our team of experienced Regulatory Project Managers.\nIntertek also holds a Human Tissue Licence, regulated and inspected by the Human Tissue Authority (HTA) in the UK, facilitating analytical studies to support our client’s clinical research programs.\n- Bioanalytical Technologies\n- Bioanalytical method development and validation\n- Clinical sample analysis (Human Plasma and Urine)\n- Pharmacokinetic (PK) and pharmacodynamic (PD) bioanalysis for small molecules and biologics\n- Metals and Inorganic Bioanalysis\n- PEGylated drug bioanalysis by NMR\n- Non-Standard Bioanalysis Methods\n- Stability testing in dose formulations\n- GCP Auditing of sub-contractors or suppliers\nWhite Paper Downloads:", "domain": "chemistry", "round": 3} +{"url": "https://www.bioscience.co.uk/product~70181", "date": "2020-08-04T11:11:30Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-34/segments/1596439735867.93/warc/CC-MAIN-20200804102630-20200804132630-00360.warc.gz", "language_score": 0.877325713634491, "token_count": 472, "dump": "CC-MAIN-2020-34", "global_id": "webtext-fineweb__CC-MAIN-2020-34__0__71842920", "lang": "en", "text": "Antibody was affinity purified using an epitope specific to KIF14 immobilized on solid support. The epitope recognized by A300-912A maps to a region between residue 1600 and the C-terminus (residue 1648) of human Kinesin Family Member 14 using the numbering given in entry NP_055690.1 (GeneID 9928). Immunoglobulin concentration was determined by extinction coefficient: absorbance at 280 nm of 1.4 equals 1.0 mg of IgG.\nepididymis secretory sperm binding protein, kinesin-like protein KIF14, MCPH20, MKS12\nbetween 1600 and C-term\n2 - 8°C\nDetection of human KIF14 by western blot and immunoprecipitation. Samples: Whole cell lysate from HeLa (5, 15 and 50 µg for WB; 1 mg for IP, 20% of IP loaded) and HEK293T (T; 50 µg) cells. Antibodies: Affinity purified rabbit anti-KIF14 antibody A300-912A used for WB at 0.04 µg/ml (A) and 1 µg/ml (B) and used for IP at 3 µg/mg lysate (B). KIF14 was also immunoprecipitated by rabbit anti-KIF14 antibodies A300-232A and A300-233A, which recognize upstream epitopes. Detection: Chemiluminescence with exposure times of 3 minutes (A) and 10 seconds (B).\nDetection of human KIF14 by immunohistochemistry and immunocytochemistry. Sample: FFPE section of human breast carcinoma (left) and formaldehyde-fixed HeLa cells (right). Antibody: Affinity purified rabbit anti-KIF14 (Cat. No. A300-912A Lot1) used at a dilution of 1:200 (1µg/ml) and 1:100 (2µg/ml). Detection: DAB (left) and red-fluorescent goat anti-rabbit IgG highly cross-adsorbed Antibody used at a dilution of 1:100 (right).", "domain": "chemistry", "round": 3} +{"url": "https://labnodes.vanderbilt.edu/publication/keywords/keyword_id/15206/keyword_name/Cell%20Respiration/id/25371", "date": "2019-11-13T17:52:49Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-47/segments/1573496667319.87/warc/CC-MAIN-20191113164312-20191113192312-00547.warc.gz", "language_score": 0.6534155607223511, "token_count": 947, "dump": "CC-MAIN-2019-47", "global_id": "webtext-fineweb__CC-MAIN-2019-47__0__62295380", "lang": "en", "text": "Depletion of a putatively druggable class of phosphatidylinositol kinases inhibits growth of p53-null tumors. Emerling BM, Hurov JB, Poulogiannis G, Tsukazawa KS, Choo-Wing R, Wulf GM, Bell EL, Shim HS, Lamia KA, Rameh LE, Bellinger G, Sasaki AT, Asara JM, Yuan X, Bullock A, Denicola GM, Song J, Brown V, Signoretti S, Cantley LC (2013) Cell 155: 844-57 Systemic elevation of PTEN induces a tumor-suppressive metabolic state. Garcia-Cao I, Song MS, Hobbs RM, Laurent G, Giorgi C, de Boer VC, Anastasiou D, Ito K, Sasaki AT, Rameh L, Carracedo A, Vander Heiden MG, Cantley LC, Pinton P, Haigis MC, Pandolfi PP (2012) Cell 149: 49-62 Molecular mechanisms of angiotensin II-mediated mitochondrial dysfunction: linking mitochondrial oxidative damage and vascular endothelial dysfunction. Doughan AK, Harrison DG, Dikalov SI (2008) Circ Res 102: 488-96 Reactive gamma-ketoaldehydes formed via the isoprostane pathway disrupt mitochondrial respiration and calcium homeostasis. Stavrovskaya IG, Baranov SV, Guo X, Davies SS, Roberts LJ, Kristal BS (2010) Free Radic Biol Med 49: 567-79 Targeting of splice variants of human cytochrome P450 2C8 (CYP2C8) to mitochondria and their role in arachidonic acid metabolism and respiratory dysfunction. Bajpai P, Srinivasan S, Ghosh J, Nagy LD, Wei S, Guengerich FP, Avadhani NG (2014) J Biol Chem 289: 29614-30 The neuromediator glutamate, through specific substrate interactions, enhances mitochondrial ATP production and reactive oxygen species generation in nonsynaptic brain mitochondria. Panov A, Schonfeld P, Dikalov S, Hemendinger R, Bonkovsky HL, Brooks BR (2009) J Biol Chem 284: 14448-56 Cholinergic regulation of fuel-induced hormone secretion and respiration of SUR1-/- mouse islets. Doliba NM, Qin W, Vatamaniuk MZ, Buettger CW, Collins HW, Magnuson MA, Kaestner KH, Wilson DF, Carr RD, Matschinsky FM (2006) Am J Physiol Endocrinol Metab 291: E525-35 Cardiolipin fatty acid remodeling regulates mitochondrial function by modifying the electron entry point in the respiratory chain. Vergeade A, Bertram CC, Bikineyeva AT, Zackert WE, Zinkel SS, May JM, Dikalov SI, Roberts LJ, Boutaud O (2016) Mitochondrion 28: 88-95 4-Hydroxy-2(E)-nonenal inhibits CNS mitochondrial respiration at multiple sites. Picklo MJ, Amarnath V, McIntyre JO, Graham DG, Montine TJ (1999) J Neurochem 72: 1617-24 Peak antibody production is associated with increased oxidative metabolism in an industrially relevant fed-batch CHO cell culture. Templeton N, Dean J, Reddy P, Young JD (2013) Biotechnol Bioeng 110: 2013-24 Nox2 as a potential target of mitochondrial superoxide and its role in endothelial oxidative stress. Nazarewicz RR, Dikalova AE, Bikineyeva A, Dikalov SI (2013) Am J Physiol Heart Circ Physiol 305: H1131-40 Hypoxia death stimulus induces translocation of p53 protein to mitochondria. Detection by immunofluorescence on whole cells. Sansome C, Zaika A, Marchenko ND, Moll UM (2001) FEBS Lett 488: 110-5 Rat diaphragm mitochondria have lower intrinsic respiratory rates than mitochondria in limb muscles. Garcia-Cazarin ML, Gamboa JL, Andrade FH (2011) Am J Physiol Regul Integr Comp Physiol 300: R1311-5\nHints: (1) double-click or double-tap to navigate to a node. (2) Grab a node and move it to arrange the graph.", "domain": "chemistry", "round": 3} +{"url": "https://www.intechopen.com/chapters/54036", "date": "2022-12-07T19:18:16Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-49/segments/1669446711218.21/warc/CC-MAIN-20221207185519-20221207215519-00603.warc.gz", "language_score": 0.8745444416999817, "token_count": 8368, "dump": "CC-MAIN-2022-49", "global_id": "webtext-fineweb__CC-MAIN-2022-49__0__294016598", "lang": "en", "text": "In 1920s, Otto Warburg made the observation that cancer cells utilize significantly more glucose than normal, healthy cells, which led him to believe that cancer cells relied on glycolysis more than healthy cells. However, many subsequent studies have shown that glucose is not only necessary for glycolysis but also for oxidative phosphorylation and production of building blocks for the synthesis of other molecules. There are many challenges associated with studying and treating lung cancer, and there is a diverse set of metabolic factors influencing the tumorigenesis and metastasis of lung cancer. Lung cancer cells rely heavily on mitochondrial respiration, and several studies have shown that inhibiting mitochondrial function is an effective method to combat lung cancer. Several agents have been used to inhibit mitochondrial function, including cyclopamine and metformin. Further, more research has noted increased levels of heme flux and function as critical to intensified oxygen consumption and accompanying amplified pathogenesis and progression of lung cancer. The upregulation of mitochondrial DNA and biogenesis genes are also correlated with lung cancer. In this chapter, we will cover these recent and emerging topics in lung cancer bioenergetics research.\n- mitochondrial respiration\n- respiration genes\n- oxidative fuels\nCells perform a variety of diverse functions and processes, all of which require some form of cellular energy. The general currency of cellular energy exists as adenosine triphosphate, a high energy molecule created by two main bioenergetic pathways: glycolysis and oxidative phosphorylation.\nGlycolysis, which translates to “sweet splitting,” is the process of breaking down a substrate, usually glucose, through a series of steps to produce two ATP molecules. This process does not require oxygen, and it is sometimes referred to as anaerobic respiration. To begin the process, glucose transporters allow glucose uptake into the cell . Hexokinase then phosphorylates glucose, which becomes glucose-6-phosphate. Glucose-6-phosphate isomerase is an enzyme that catalyzes the reversible isomerization of glucose-6-phosphate and fructose-6-phosphate which follow the pentose phosphate pathway that produces nucleotides and NADPH, or the glycolytic pathway to make lactate. Fructose-6-phosphate undergoes a reaction facilitated by phosphofructokinase-1 to become fructose-1,6 bisphosphate, which then becomes glyceraldehyde-3-phosphate for glycolysis or dihydroxyacetone phosphate to help create lipids. Glyceraldehyde-3-phosphate becomes glycerate-2-phosphate by glyceraldehyde-3-phosphate dehydrogenase. Glycerate-2-phosphate becomes phosphoenol pyruvate via enolase. To produce the two ATP of glycolysis, pyruvate kinase catalyzes the conversion of phosphoenol pyruvate into pyruvate (see Figure 1). Finally, pyruvate is converted to lactate, a process which is mediated by the enzyme lactate dehydrogenase-A. This process generates NAD+ from NADH. The production of NAD+ allows the process of glycolysis to be cyclical.\nOxidative phosphorylation has many more steps than glycolysis, and it requires oxygen. Oxidative phosphorylation creates significantly more ATP per substrate molecule than does glycolysis. It is a slower process, and it is made possible by mitochondrial respiratory chain complexes.\nMitochondria are the site of oxidative phosphorylation (see Figure 2). Mitochondria are present in many diverse types of cells in eukaryotes, and they are capable of producing large quantities of energy. The respiratory chain complexes in mitochondria are responsible for facilitating the reactions associated with oxidative phosphorylation. Consequently, the unique bioenergetics of cancer suggests altered mitochondria. Indeed, some genes have been found to be mutated in mitochondria (see Figure 2).\nThe process of oxidative phosphorylation requires several protein complexes, named Complex I–V, all of which are partly coded by mitochondrial DNA with the exception of Complex II . Within the inner membrane of the mitochondria, there are electron carriers that are critical for mitochondrial respiration. Importantly, up to 2% of electrons cycling through the electron transport chain can escape the process, and this creates reactive oxygen species, or ROS . These ROS can cause significant damage to mitochondrial DNA.\nPyruvate is transported into the mitochondria or transformed into lactate and nicotinamide adenine dinucleotide (NAD) by lactate dehydrogenase (LDH). Direct transport of pyruvate into the mitochondria across the outer mitochondrial membrane, intermembrane space, and inner mitochondrial membrane is facilitated by mitochondrial pyruvate carrier (MPC). Mitochondrial pyruvate carrier also facilitates the removal of hydroxide from the mitochondria. Once within the mitochondrial matrix, pyruvate is converted to acetyl coenzyme A (acetyl CoA) via pyruvate dehydrogenase catalysis. Acetyl CoA enters the tricarboxylic acid cycle, and succinate is formed via organic acid oxidation. NADH contains electrons that go through the electron transport chain (ETC), which consists of mitochondrial Complexes I–IV (see Figure 2). Complex I, alternatively called NADH dehydrogenase or NADH ubiquinone oxidoreductase, marks the beginning of the electron transport chain and is also the largest of the five mitochondrial complexes . From Complex I, the electron transport chain brings electrons toward coenzyme Q through the inner mitochondrial membrane. Alternatively, electrons can skip Complex I entirely. The transport of these electrons is mediated by flavin-containing enzyme complexes and they also reach coenzyme Q via this alternative pathway . From coenzyme Q, electrons are transferred to Complex III. Yet another pathway to coenzyme Q is possible via Complex II. Succinate is reduced and the electrons from the reduction of succinate are taken to coenzyme Q and Complex III. Complex III and cytochrome c shift electrons to Complex IV. The movement of electrons over the inner mitochondrial matrix by Complexes I, III, and IV creates a proton gradient. This causes protons to enter the mitochondrial matrix, a process allowed by Complex V, ATP synthase (V), and causes the production of ATP (see Figure 2). Taken together, Complexes I–V facilitate oxidative phosphorylation and can create up to 36 mol of ATP per mol glucose. ROS created via oxidative phosphorylation can be used to regenerate NAD+. It is important to note that many cancer cells prefer glutamine as opposed to glucose . This may be because cancer mimics the effects of starvation on the body. During starvation, the body utilizes amino acids from a pool of amino acids, and then breaks down skeletal muscle to replenish the pool of amino acids. One of the major amino acids consumed in this process is glutamine, the very same amino acid substrate which many cancer cells are remarkably adept at converting for energy. Many glycolytic molecules are considerably upregulated in cancer, including hexokinase II, glucose transporters, pyruvate kinase, and lactate dehydrogenase-A . These molecules serve as targets for chemotherapy drugs. In the same way, many oxidative phosphorylation enzymes and molecules are differentially regulated in cancer.\n2. Unique clinical problems of lung cancer\nLung cancer screening with low-dose computer tomography has proven to be effective in significantly reducing mortality of lung cancer patients through detection of nonsymptomatic patients at early stages . These early stage patients are typically treated with surgical or radiological procedures followed by periodical surveillance with radiographic imaging. Although these curative treatments have been successful in saving many of these patients from lung cancer, 30–60% of the patients are predicted to present with local or distant recurrences (mostly within 5 years, but some beyond the first 5 year period) . This is a unique problem for lung cancer that limits overall survival rates in these patients to less than 60% despite early detection, as compared with greater than 95% in the case of early stage prostate or breast cancers . If these patients can be accurately identified at the time of initial treatment, adding appropriate adjuvant therapy to their initial treatment plan may significantly increase their survival rates. However, adjuvant chemotherapy on Stages I–III non-small cell lung cancer (NSCLC) patients showed only marginal 5-year overall survival benefits of less than 6% in meta-analyses of recent clinical trials [10, 11]. Neither epidermal growth factor receptor-targeting therapy nor immunotherapy showed significant benefits in adjuvant settings for early stage NSCLC patients [12, 13]. Thus, no methods are currently available to effectively treat these patients. However, several recent experiments strongly suggest that targeting mitochondria will yield effective strategies to treat lung cancer patients in the future [14–18].\n3. Lung cancer cells are extremely susceptible to inhibitors of mitochondria\nSeveral studies have suggested that inhibiting mitochondrial function makes drug-resistant tumors more sensitive to treatment [14–16, 18]. When oxidative phosphorylation was suppressed, cancer became less able to proliferate in an anchorage-independent manner . This drastically limits the tumorigenic capacity of cancer cells. Because mitochondria are crucial for the electron transport chain and therefore oxidative phosphorylation, two processes which are especially prominent in cancer cells, inhibiting mitochondrial function essentially starves the cancer cell of ATP, affecting processes such as growth and metastasis of tumors. However, because healthy cells have drastically lower levels of oxidative phosphorylation and often significantly lower energy requirements, healthy cells are not as strongly impacted as cancer cells and can maintain functionality. Consequently, when the mitochondria of tumor cells are tampered with to inhibit oxidative phosphorylation, these tumor cells become significantly more susceptible to cytotoxic drugs [16, 19]. Agents such as cyclopamine tartrate, a water-soluble derivative of a molecule found in corn lilies ; metformin, an antidiabetic drug ; BAY 87-2243, a lead structure ; and microRNA-126, a microRNA have shown potential to interfere with normal mitochondrial function in cancer cells. These molecules interact with various aspects of mitochondrial function, such as interfering with Hedgehog signaling and inhibiting Complex I. Cyclopamine tartrate functions by inhibiting Hedgehog signaling . Cyclopamine was the first chemical found which effectively inhibited Hedgehog signaling. Cyclopamine tartrate is an analog of cyclopamine, but it is more soluble in water than cyclopamine. The mechanism by which cyclopamine and cyclopamine tartrate work has been studied extensively. Smoothened (SMO) is a G protein-coupled receptor. SMO is responsible for facilitating Hedgehog signaling. Cyclopamine tartrate inhibits SMO, thereby inhibiting Hedgehog signaling. In NSCLC HCC4017 cells, studies have demonstrated intensified oxygen consumption compared to benign HBEC cells from the same patient . Low levels of glucose also contribute to higher oxygen consumption rates, and low levels of glutamine lower oxygen consumption rates. Low levels of glucose also encourage NSCLC cells to utilize glutamine, and low levels of glutamine contribute to increased glucose consumption. Although NSCLC cell lines have varying levels of sensitivity to cyclopamine tartrate, this agent can be used to induce apoptosis by targeting these aerobic respiration pathways. Further, Cyclopamine tartrate helps generate ROS, which disturb the mitochondria in tumor cells. Cyclopamine tartrate can cause mitochondrial fission and fragmentation in several types of NSCLC cells, including H1299, A549, and H460 cells. Consequently, cyclopamine tartrate reduces mitochondrial respiration. Metformin has been used for years to combat Type II diabetes, but as of 2001, scientists were only beginning to take note of the anticancer properties of the drug in mammals . Scientists also noticed that those individuals taking metformin for diabetes had lower overall rates of cancer. Recently, researchers have shed some light onto the mechanism of metformin. Metformin inhibits mitochondrial Complex I by reducing oxygen consumption in the presence of malate and pyruvate, which create NADH as a substrate for Complex I . Metformin has also been reported to interrupt the tricarboxylic acid cycle, the methionine cycle, and the folate cycle, as well as decrease nucleotide synthesis.\n4. Enhanced heme function is important for NSCLC cells\nHeme, or iron protoporphyrin IX, is notably and inextricably linked with oxygen transport, storage, and utilization. Most mammalian cells can synthesize heme\nWhen levels of heme flux and function are increased, levels of oxygen utilization are also increased. Intensified oxygen consumption allows increased cancer cell proliferation and function . Recent research suggests that non-small cell lung cancer (NSCLC) cells upregulate proteins that stimulate heme synthesis, uptake, and function. When these proteins abound, heme is significantly upregulated, and aids in lung cancer progression. Notably, affected proteins include ALAS, HRG1, HCP1, cytoglobins, and cytochromes .\nWhen NSCLC cells were compared to normal cells from the same patient, studies showed that rates of heme biosynthesis were significantly raised in cancerous cells . ALAS1, a rate limiting enzyme in nonerythroid heme synthesis, is higher in NSCLC cells. Succinyl acetone has been used to lower heme levels by inhibiting heme synthesis. Succinyl acetone attacks delta-aminolevulinic acid dehydratase.\n5. Mitochondrial respiration and biogenesis genes are upregulated in lung tumor cells\nLung cancer often has a genetic basis. Up to 60% of lung adenocarcinoma tissues have a driver mutation. These genes include Kirsten rat sarcoma viral oncogene (KRAS), epidermal growth factor receptor (EGFR), anaplastic lymphoma kinase (ALK), and proto-oncogene B-Raf (BRAF) [31, 32]. In lung adenocarcinoma, the type of NSCLC most frequently found to plague nonsmokers, smoking causes a very different pathway of tumorigenesis . In nonsmokers, there are four times as many differently expressed genes as in smokers . This is thought to be due to the lung tumor locally evolving in nonsmokers. By contrast, in smokers the lung tumor is thought to evolve from a patch of genetically altered tissue. Furthermore, some of the genes that were found to be upregulated in smokers were upregulated more depending on how frequently the smoker smoked. Malic enzyme (ME) expression is also significantly increased in the lung tissues of smokers compared to nonsmokers . The EGFR pathway is the most common signaling pathway for lung cancer, and the mutation rate of genes of the EGFR pathway reach 70–80% . About 30–35% of lung adenocarcinoma genetic variation is attributable to the KRAS mutation. In NSCLC cells, 97% of KRAS mutations occur in codon 12 or 13, and by testing codon 12 for KRAS mutation in bronchoalveolar lavage, scientists can diagnose lung cancer. Some labs have identified proteins that are overexpressed significantly in lung adenocarcinomas. Particularly, ATP synthase subunit d (ATP5D) is significantly over-expressed in lung adenocarcinomas (tumor: n = 93, 1.155 + 0.418; normal: n = 10, 0.663 + 0.210; p value: <0.0001) . Some common marker genes include neuron-specific enolase, carcinoembryonic antigen, cytokeratin 19 fragments (CYFRA 21-1), squamous cell carcinoma antigen, cancer antigen CA 125, and tissue polypeptide antigen, although no one marker gene is as efficient as multiple marker genes at predicting and diagnosing lung adenocarcinomas. Both ME and ATP-citrase lyase (ACLY) are enzymes related to aerobic glycolysis and fatty acid synthesis. They are both correlated with NSCLC cells, and ACLY tends to be more localized, whereas ME tends to signify mediastinal lymph nodes, a site of metastasis in the human body . Interestingly, in young patients, overexpression of ACLY and/or ME correlated with extended survival compared to patients who did not overexpress ACLY and/or ME. However, in older patients, overexpression of ACLY and/or ME is predictive of shorter period of survival as compared to patients who do not overexpress ACLY and/or ME. It can therefore be inferred that potential rising treatments must take into consideration the age group of the afflicted patient. Mitochondrial respiration genes have also been shown to be upregulated in lung tumor cells. In lung adenocarcinoma, many genes, especially those associated with mitochondrial respiration, have been shown to be differently expressed than in healthy tissue . One study noted 535 upregulated and 465 downregulated differentially expressed genes in lung adenocarcinoma comparing matched tissues of the same patients. One prominent class of upregulated genes is related to mitochondrial oxidative phosphorylation and the electron transport chain. ATP5D, UQCRC2, NDUFA2, NDUFB8, NDUFA7, NDUFA1, NDUFB1, NDUFS7, UQCR11, NDUFV1, NDUFV2, and NDUFS3 are specifically related to bioenergetic pathways including mitochondrial ATP synthesis-coupled electron transport and the electron transport chain . Additionally, genes associated with mitochondrial biogenesis are specifically upregulated in circulating lung cancer cells and have been reported to be essential for their metastatic potential . By studying metastatic cancers, LeBleu et al. investigated the role of peroxisome proliferator-activated receptor gamma, coactivator 1 alpha (PGC-1α) in enhancing metastatic potential by increasing oxygen consumption, mitochondrial biogenesis, and oxidative phosphorylation rates. The effect of PGC-1α on respiration appears to be key to allowing metastasis specifically, and does not appear to strongly affect cancer cell proliferation, epithelial-to-mesenchymal transfer, or primary tumor growth. Activating mutations in Ras guanosine nucleotide-binding proteins result in insensitivity to GTPase-activating proteins . These Ras mutations are common in human cancers . Activated GTP-bound Ras family members increase glucose uptake and flux, which partly promotes the survival and proliferation of lung cancer . This effect is important because it increases the capacity for energy production in lung adenocarcinoma cells. Activated Ras also increases tricarboxylic acid cycle activity and oxygen consumption, which further enables cancerous cells to produce energy and therefore increases carcinogenic and metastatic potential of cancer cells. Cytochrome c oxidase is activated by Ras . Cytochrome c oxidase contains 3 mitochondrial DNA–encoded and 10 genomic DNA–encoded subunits and forms Complex IV of the electron transport chain . In some types of cancer, levels of cytochrome c oxidase are significantly elevated [40, 41]. Without activated cytochrome c oxidase, A549 lung adenocarcinoma is incapable of growth . Still more mutations in nuclear genes affecting mitochondrial form and function have been linked with lung cancer. Succinate dehydrogenase, including SDHB, SDHC, and SDHD genes, and isocitrate dehydrogenase, including IDH1 and IDH2 genes, code for mitochondrial components . By affecting the structure of the mitochondria, these genes affect the function of the mitochondria, and consequently are associated with or considered causal to cancer. Due to the large genetic variation between lung tumor cells, or tumor heterogeneity, chemoresistance is a major problem in lung cancer treatment. Many chemicals which are effective on certain types of lung cancer are not effective on other types of lung cancer. Furthermore, individual tumors possess intratumoral heterogeneity. That is, the tumor has nonidentical cells. Therefore, while some cell types may respond favorably to treatment, other cell types may not. Consequently, over time, these cell types begin to dominate the tumor and the tumor becomes chemoresistant by acquiring genetic and epigenetic changes. This process was first proposed by Nowell as clonal evolution . Understanding tumor heterogeneity and variation among NSCLC categories therefore significantly increases the ability of research to successfully unearth potential treatments and cures for lung cancer.\n6. Mitochondrial DNA is correlated with lung cancer\nMitochondrial DNA is especially susceptible to reactive oxygen species because it does not have protective histones and introns . Further, mitochondria lack the capacity to repair damaged mitochondrial DNA. Consequently, mitochondrial DNA mutates more frequently than other genomic DNA . The instability of mitochondrial DNA can have devastating effects on the cell, including mutations and copy number alterations . Both germline and somatic mitochondrial DNA defects are associated with cancer. Mitochondrial DNA is thought to be able to function as a driver or as a complementary gene mutation of carcinogenesis according to the multiple-hit model, thereby allowing increased clonogenic and/or mutagenic capacities in cancer cells . To combat these mutations, mitochondria increase their copy number drastically. Some studies suggest that the number of copies of mitochondrial DNA is strongly correlated with carcinogenesis [44, 46]. This relationship has been supported by several other labs [47, 48]. This relationship has been especially noted in lung adenocarcinoma. It is important to note that some diseases have a causal effect with cancer, and may also increase mitochondrial DNA copy number. To overcome this bias due to a latent disease, mitochondrial DNA was measured in peripheral white blood cells. The results suggested that even in the absence of a causal disease, increased copy number is indicative of an increased risk of lung cancer . Importantly, this connection does not hold true for all types of cancer [47, 48]. Some cancers express lower mitochondrial copy numbers. However, in lung adenocarcinoma, the mitochondrial copy number is increased compared to controls. There is also a strong correlation between mitochondrial DNA copy number and TFAM (Transcriptional Factor A, Mitochondria) expression . TFAM is a factor for transcription and replication and in nucleoids. TFAM binds to mitochondrial DNA. Significantly, the gene set responsible for controlling the tricarboxylic acid cycle and respiratory electron transport is most commonly correlated to copy number. In NSCLC cells, epithelial-to-mesenchymal transition is thought to be the critical moment defining metastatic potential . It is thought that during epithelial-to-mesenchymal transition, the copy number of mitochondrial DNA is altered. In A549 cells, copy number increased from 1700 to 2800 during epithelial-to-mesenchymal transition.\n7. Stromal cells in the tumor microenvironment contribute bioenergetic molecules to cancer cells\nDespite the deregulation of normal metabolic processes in tumor cells and the many contributors to mitochondrial dysfunction, tumors still have remarkable capacity to perform oxidative phosphorylation. This is in part due to a phenomenon where surrounding tissues contribute fuel sources to tumor tissues . A two-compartment model was proposed in 2012 to explain this process [51–53]. Glycolytic stromal cells produce l-lactate and ketone bodies which are utilized by oxidative epithelial cancer cells. The metabolites produced by these fibroblasts (see Figure 3) provide fuel for cancer proliferation via oxidative phosphorylation . This process is thought to be mediated by pyruvate kinase isoforms. Glutamine helps to fuel this process [55–57]. It appears as though the tumor cells take advantage of the stromal cells in a form of micro-level commensalism .\nEmerging evidence increasingly shows that mitochondrial respiration is key to cancer bioenergetics. Particularly, heme is a central molecule in mitochondrial respiration. Many lines of evidence from epidemiological studies, gene expression studies of human tumor tissues, and molecular studies of cancer cell lines indicate that functions of heme and oxygen-utilizing hemoproteins are critical for tumorigenesis, particularly lung tumorigenesis. Enhanced heme flux and function is a key feature of non-small cell lung cancer cells. Consistent with these observations, many cancer cells are susceptible to inhibitors of mitochondrial function and heme biosynthesis. A better understanding of the relationships between mitochondrial and heme function with cancer bioenergetics should facilitate the development of effective strategies to treat cancers, particularly lung cancer.\nWork on lung cancer in Dr. Li Zhang’s lab is funded by the CPRIT Grant and the Cecil H and Ida Green Funds from the University of Texas at Dallas.\nZhang, Y. and J.M. Yang, Altered energy metabolism in cancer: a unique opportunity for therapeutic intervention. Cancer Biol Ther, 2013. 14(2): pp. 81–9.\nVan Gisbergen, M.W., et al., How do changes in the mtDNA and mitochondrial dysfunction influence cancer and cancer therapy? Challenges, opportunities and models. Mutat Res Rev Mutat Res, 2015. 764: pp. 16–30.\nSt-Pierre, J., et al., Topology of superoxide production from different sites in the mitochondrial electron transport chain. J Biol Chem, 2002. 277(47): pp. 44784–90.\nVoets, A.M., et al., Transcriptional changes in OXPHOS complex I deficiency are related to anti-oxidant pathways and could explain the disturbed calcium homeostasis. Biochim Biophys Acta, 2012. 1822(7): pp. 1161–8.\nSmeitin, J., The genetics and pathology of oxidative phosphorylation. Nat Rev, 2001. 2(5): pp. 342–52.\nvan den Heuvel, A.P., et al., Analysis of glutamine dependency in non-small cell lung cancer: GLS1 splice variant GAC is essential for cancer cell growth. Cancer Biol Ther, 2012. 13(12): pp. 1185–94.\nNational Lung Screening Trial Research Team, et al., Reduced lung-cancer mortality with low-dose computed tomographic screening. N Engl J Med, 2011. 365(5): pp. 395–409.\nDemicheli, R., et al., Recurrence dynamics for non-small-cell lung cancer: effect of surgery on the development of metastases. J Thorac Oncol, 2012. 7(4): pp. 723–30.\nSiegel, R.L., K.D. Miller, and A. Jemal, Cancer statistics, 2015. CA Cancer J Clin, 2015. 65(1): pp. 5–29.\nBurdett, S., et al., Adjuvant chemotherapy for resected early-stage non-small cell lung cancer. Cochrane Database Syst Rev, 2015. 3: pp. CD011430.\nPignon, J.P., et al., Lung adjuvant cisplatin evaluation: a pooled analysis by the LACE Collaborative Group. J Clin Oncol, 2008. 26(21): pp. 3552–9.\nKelly, K., et al., Adjuvant erlotinib versus placebo in patients with stage IB-IIIA non-small-cell lung cancer (RADIANT): a randomized, double-blind. Phase III Trial J Clin Oncol, 2015. 33(34): pp. 4007–14.\nPujol, J.L., et al., Safety and immunogenicity of MAGE-A3 cancer immunotherapeutic with or without adjuvant chemotherapy in patients with resected stage IB to III MAGE-A3-positive non-small-cell lung cancer. J Thorac Oncol, 2015. 10(10): pp. 1458–67.\nViale, A., D. Corti, and G.F. Draetta, Tumors and mitochondrial respiration: a neglected connection. Cancer Res, 2015. 75(18): pp. 3685–6.\nEllinghaus, P., et al., BAY 87-2243, a highly potent and selective inhibitor of hypoxia-induced gene activation has antitumor activities by inhibition of mitochondrial complex I. Cancer Med, 2013. 2(5): pp. 611–24.\nCavelli, L.R., Diminished tumorigenic phenotype after deplition of mitochondrial DNA. Cell Growth Differ, 1997. 8: pp. 1189–98.\nAlam, M.M., et al., A holistic view of cancer bioenergetics: mitochondrial function and respiration play fundamental roles in the development and progression of diverse tumors. Clin Transl Med, 2016. 5(1): pp. 3.\nLuengo, A., Understanding the complex-I-ty of metformin action: limiting mitochondrial respiration to improve cancer therapy. BMC Biol, 2014.\nGao, C., et al., Cancer stem cells in small cell lung cancer cell line H446: higher dependency on oxidative phosphorylation and mitochondrial substrate-level phosphorylation than non-stem cancer cells. PLoS One, 2016. 11(5): pp. e0154576.\nAlam, M.M., et al., Cyclopamine tartrate, an inhibitor of hedgehog signaling, strongly interferes with mitochondrial function and suppresses aerobic respiration in lung cancer cells. BMC Cancer, 2016. 16: pp. 150.\nTomasetti, M., et al., MicroRNA-126 suppresses mesothelioma malignancy by targeting IRS1 and interfering with the mitochondrial function. Antioxid Redox Signal, 2014. 21(15): pp. 2109–25.\nJara, J.A. and R. Lopez-Munoz, Metformin and cancer: between the bioenergetic disturbances and the antifolate activity. Pharmacol Res, 2015. 101: pp. 102–8.\nKuhn, K.S., et al., Glutamine as indispensable nutrient in oncology: experimental and clinical evidence. Eur J Nutr, 2010. 49(4): pp. 197–210.\nHooda, J., et al., Evaluating the association of heme and heme metabolites with lung cancer bioenergetics and progression. Metabolomics, 2015. 5(3): pp. 150.\nHooda, J., A. Shah, and L. Zhang, Heme, an essential nutrient from dietary proteins, critically impacts diverse physiological and pathological processes. Nutrients, 2014. 6(3): pp. 1080–102.\nZhu, Y., T. Hon, and L. Zhang, Heme initiates changes in the expression of a wide array of genes during the early erythroid differentiation stage. Biochem Biophys Res Commun, 1999. 258(1): pp. 87–93.\nYe, W. and L. Zhang, Heme controls the expression of cell cycle regulators and cell growth in HeLa cells. Biochem Biophys Res Commun, 2004. 315(3): pp. 546–54.\nYao, X., et al., Heme controls the regulation of protein tyrosine kinases Jak2 and Src. Biochem Biophys Res Commun, 2010. 403(1): pp. 30–5.\nChen, J.J., Regulation of protein synthesis by the heme-regulated eIF2α kinase: relevance to anemias. Blood, 2007. 109(7): pp. 2693–9.\nHooda, J., et al., Enhanced heme function and mitochondrial respiration promote the progression of lung cancer cells. PLoS One, 2013. 8(5): pp. e63402.\nKris, M.G., Identification of driver mutations in tumor specimens from 1000 patients with lung adenocarcinoma: the NCI’s Lung Cancer Mutation Consortium (LCMC). J Clin Oncol, 2011. 29(15_suppl): pp. CRA7506.\nXu, H., et al., Gene expression profiling analysis of lung adenocarcinoma. Braz J Med Biol Res, 2016. 49(3): pp. e4861.\nPowell, C.A., et al., Gene expression in lung adenocarcinomas of smokers and nonsmokers. Am J Respir Cell Mol Biol, 2003. 29(2): pp. 157–62.\nCsanadi, A., et al., Prognostic value of malic enzyme and ATP-citrate lyase in non-small cell lung cancer of the young and the elderly. PLoS One, 2015. 10(5): pp. e0126357.\nChen, G., Proteomic analysis of lung adenocarcinoma: identification of a highly expressed set of proteins in tumors. Clin Cancer Res, 2002. 8: pp. 2298–305.\nLeBleu, V.S., et al., PGC-1 alpha mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis. Nat Cell Biol, 2014. 16(10): pp. 992–1003, 1–15.\nTelang, S, Cytochrome c oxidase is activated by the oncoprotein Ras and is required for A549 lung adenocarcinoma growth. Mol Cancer, 2012.\nMinamoto, T., M. Mai, and Z. Ronai, K-ras mutation: early detection in molecular diagnosis and risk assessment of colorectal, pancreas, and lung cancers—a review. Cancer Detect Prev, 2000. 24(1): pp. 1–12.\nDejean, L., et al., Activation of Ras cascade increases the mitochondrial enzyme content of respiratory competent yeast. Biochem Biophys Res Commun, 2002. 293(5): pp. 1383–8.\nKadenbach, B., et al., Mitochondrial energy metabolism is regulated via nuclear-coded subunits of cytochrome c oxidase. Free Radic Biol Med, 2000. 29(3–4): pp. 211–21.\nWang, Z., et al., Cyclin B1/Cdk1 coordinates mitochondrial respiration for cell-cycle G2/M progression. Dev Cell, 2014. 29(2): pp. 217–32.\nSequist, L.V., et al., Implementing multiplexed genotyping of non-small-cell lung cancers into routine clinical practice. Ann Oncol, 2011. 22(12): pp. 2616–24.\nNowell, P.C., The clonal evolution of tumor cell populations. Science, 1976. 194(4260): pp. 23–8.\nHosgood, H.D. et al., Mitochondrial DNA copy number and lung cancer risk in a prospective cohort study. Carcinogenesis, 2010. 31(5): pp. 847–9.\nWallace, D.C., Mitochondrial DNA sequence variation in human evolution and disease. Proc Natl Acad Sci U S A, 1994. 91(19): pp. 8739–46.\nAkgul, E.O., et al., MtDNA depletions and deletions may also be important in pathogenesis of lung cancer. Respir Med, 2013. 107(11): pp. 1814.\nMi, J., et al., The relationship between altered mitochondrial DNA copy number and cancer risk: a meta-analysis. Sci Rep, 2015. 5: pp. 10039.\nReznik, E., et al., Mitochondrial DNA copy number variation across human cancers. Elife, 2016. 5: pp. e10769.\nXie, M., et al., Activation of notch-1 enhances epithelial-mesenchymal transition in gefitinib-acquired resistant lung cancer cells. J Cell Biochem, 2012. 113(5): pp. 1501–13.\nGalluzzi, L., et al., Metabolic targets for cancer therapy. Nat Rev Drug Discov, 2013. 12(11): pp. 829–46.\nSalem, A.F., et al., Two-compartment tumor metabolism: autophagy in the tumor microenvironment and oxidative mitochondrial metabolism (OXPHOS) in cancer cells. Cell Cycle, 2012. 11(13): pp. 2545–56.\nIcard, P., et al., The metabolic cooperation between cells in solid cancer tumors. Biochim Biophys Acta, 2014. 1846(1): pp. 216–25.\nMartinez-Outschoorn, U.E., M.P. Lisanti, and F. Sotgia, Catabolic cancer-associated fibroblasts transfer energy and biomass to anabolic cancer cells, fueling tumor growth. Semin Cancer Biol, 2014. 25: pp. 47–60.\nSotgia, F., et al., Mitochondrial metabolism in cancer metastasis: visualizing tumor cell mitochondria and the “reverse Warburg effect” in positive lymph node tissue. Cell Cycle, 2012. 11(7): pp. 1445–54.\nDeBerardinis, R.J. and T. Cheng, Q’s next: the diverse functions of glutamine in metabolism, cell biology and cancer. Oncogene, 2010. 29(3): pp. 313–24.\nFan, J., et al., Glutamine-driven oxidative phosphorylation is a major ATP source in transformed mammalian cells in both normoxia and hypoxia. Mol Syst Biol, 2013. 9: pp. 712.\nWhitaker-Menezes, D., et al., Evidence for a stromal-epithelial “lactate shuttle” in human tumors: MCT4 is a marker of oxidative stress in cancer-associated fibroblasts. Cell Cycle, 2011. 10(11): pp. 1772–83.", "domain": "chemistry", "round": 3} +{"url": "https://grayfantasy.ru/explain-radio-carbon-dating-kids-8963.html", "date": "2020-11-27T02:17:04Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-50/segments/1606141189038.24/warc/CC-MAIN-20201127015426-20201127045426-00406.warc.gz", "language_score": 0.9533547759056091, "token_count": 290, "dump": "CC-MAIN-2020-50", "global_id": "webtext-fineweb__CC-MAIN-2020-50__0__147893031", "lang": "en", "text": "Explain radio carbon dating kids\nHistory, anthropology, and archaeology are three distinct but closely related bodies of knowledge that tell man of his present by virtue of his past.Historians can tell what cultures thrived in different regions and when they disintegrated.Before deciding on using carbon dating as an analytical method, an archaeologist must first make sure that the results of radiocarbon dating after calibration can provide the needed answers to the archaeological questions asked.The implication of what is represented by the carbon 14 activity of a sample must be considered.Radiocarbon dating has been around for more than 50 years and has revolutionized archaeology.Carbon 14 dating remains to be a powerful, dependable and widely applicable technique that is invaluable to archaeologists and other scientists.\nWhen a living thing dies, it stops interacting with the biosphere, and the carbon 14 in it remains unaffected by the biosphere but will naturally undergo decay.\nGreat care must be exercised when linking an event with the context and the context with the sample to be processed by radiocarbon dating.\nAn archaeologist must also make sure that only the useful series of samples are collected and processed for carbon dating and not every organic material found in the excavation site.\nOther potential contaminants include paper, cardboard, cotton wool, string and cigarette ash.3.\nSample storage Samples must be stored in packaging materials that will protect them during transport and even during prolonged storage.", "domain": "chemistry", "round": 3} +{"url": "http://www.antibodies-online.com/abstract/Autophagy+Related+12+(ATG12)+ELISA+Kit/", "date": "2017-05-28T07:16:35Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-22/segments/1495463609605.31/warc/CC-MAIN-20170528062748-20170528082748-00391.warc.gz", "language_score": 0.8828608989715576, "token_count": 1180, "dump": "CC-MAIN-2017-22", "global_id": "webtext-fineweb__CC-MAIN-2017-22__0__159396795", "lang": "en", "text": "Use your antibodies-online credentials, if available.\nNo Products on your Comparison List.\nYour basket is empty.\nFind out more\nAutophagy is a process of bulk protein degradation in which cytoplasmic components, including organelles, are enclosed in double-membrane structures called autophagosomes and delivered to lysosomes or vacuoles for degradation. Additionally we are shipping ATG12 Antibodies (218) and ATG12 Proteins (19) and many more products for this protein.\nShowing 4 out of 10 products:\nAnalysis of hepatitis B virus capsid maturation steps revealed that Rab33B and Atg5/12/16L1 are required for proper particle assembly and/or stability.\nreveal a novel interconnection between autophagy, proteasome activity, and cell death mediated by the ubiquitin-like properties of ATG12\nThe results revealed that the expression of Atg12 and LC3 (show MAP1LC3A ELISA Kits) II/LC3 (show MAP1LC3A ELISA Kits) I in the chondrocytes treated with TXC increased, compared to that in the untreated chondrocytes\nCav-1 competitively interacts with the ATG12-ATG5 system to suppress the formation and function of the latter in lung epithelial cells.\nATG12 is a novel determinant of breast cancer primary resistance to HER1 (show EGFR ELISA Kits)/2-targeted therapeutics.\nstudy to identify role of conjugation between ATG12 and ATG5 in LC3 lipidation; structural and mutational analyses of ATG12~ATG5-ATG16N revealed the conjugation generates a patch across ATG12 and ATG5 required for E3 activity\nThese data relate LC3B, ATG5 and ATG12 to mitochondrial quality control after oxidative damage, and to cellular longevity.\nThe Atg12 is as a positive mediator of mitochondrial apoptosis and show that Atg12 directly regulates the apoptotic pathway by binding and inactivating prosurvival Bcl-2 (show BCL2 ELISA Kits) family members, including Bcl-2 (show BCL2 ELISA Kits) and Mcl-1 (show MCL1 ELISA Kits).\nCalpain1 plays an important role in controlling the levels of autophagy in normal living cells by regulating the levels of a key signaling molecule, ATG12-ATG5 conjugate.\nHuman Apg3p (show ATG3 ELISA Kits)/Aut1p homologue is an authentic E2 enzyme for multiple substrates, GATE-16 (show GABARAPL2 ELISA Kits), GABARAP (show GABARAP ELISA Kits), and MAP-LC3 (show MAP1LC3A ELISA Kits), and facilitates the conjugation of hApg12p to hApg5p\nmiR-30b inhibited autophagy to alleviate hepatic ischemia-reperfusion injury by decreasing the Atg12-Atg5 conjugate.\nAlthough genetic deletion of either Atg12 or Atg5 (show ATG5 ELISA Kits) renders POMC (show POMC ELISA Kits) neurons autophagy-deficient, mice lacking Atg5 (show ATG5 ELISA Kits) in POMC (show POMC ELISA Kits) neurons do not exhibit these phenotypes.\nATG12-ATG3 (show ATG3 ELISA Kits) interacts with Alix (show PDCD6IP ELISA Kits) to promote basal autophagic flux and late endosome function.\nAtg5 (show ATG5 ELISA Kits)-Atg12/Atg16L1 (show ATG16L1 ELISA Kits) protein complex is required for IFNgamma-mediated host defense against murine norovirus infection.\nVaccinia virus actively disrupts the cellular autophagy through a novel molecular mechanism that is associated with aberrant LC3 (show MAP1LC3A ELISA Kits) lipidation and a direct conjugation between ATG12 and ATG3 (show ATG3 ELISA Kits).\nDespite forming the Atg12-Atg5-Atg16L2 complex, Atg16L2 is not recruited to phagophores and is mostly present in the cytosol.\nAutophagy participated the process of immune response of anti-MTB (show NCAPG2 ELISA Kits). Atg12 were the important molecule which control the formation of autophagy when MTB (show NCAPG2 ELISA Kits) infected.\nOverexpression of Atg5 or Atg12 resulted in Atg5-Atg12 conjugate formation and suppression of RNA-mediated signaling.\nAutophagy is a process of bulk protein degradation in which cytoplasmic components, including organelles, are enclosed in double-membrane structures called autophagosomes and delivered to lysosomes or vacuoles for degradation. ATG12 is the human homolog of a yeast protein involved in autophagy (Mizushima et al., 1998\nautophagy-related protein 12\n, ubiquitin-like protein ATG12\n, ATG12 autophagy related 12 homolog\n, Apg12 (autophagy, yeast) homolog\n, autophagy-related 12\n, potential preautophagosome nucleating protein Atg12", "domain": "chemistry", "round": 3} +{"url": "https://tohoku.elsevierpure.com/en/publications/the-dependency-of-the-crack-growth-rate-on-the-loading-pattern-an", "date": "2024-03-04T05:15:07Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707947476413.82/warc/CC-MAIN-20240304033910-20240304063910-00836.warc.gz", "language_score": 0.9375675320625305, "token_count": 527, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__104633395", "lang": "en", "text": "The stress corrosion cracking (SCC) growth rate of a warm-rolled (WR) 316L stainless steel contoured double cantilever (CDCB) specimen was measured in high purity water at various temperatures and under various loading patterns. An alternating current potential drop (ACPD) technique was used to monitor the crack growth kinetics throughout the tests. The fracture surface exhibited typical intergranular SCC characteristics. Depending on the test conditions, three kinds of crack growth kinetics, i.e., increasing with time then becoming steady, being constant during the whole period, decreasing with time then becoming steady, were identified and are described. The steady state crack growth rate (CGR) values are used to quantify the effects of the loading pattern and the environmental temperature. A moderate increase in the crack growth rate was encountered by employing periods of unloading and reloading to form a trapezoidal loading pattern and the enhancement factor was found to depend on the holding time and the times for unloading and reloading. It was found that the crack growth is thermally activated; however, the apparent activation energy is not constant but seems to be greater at higher temperatures. Several types of temperature-dependent crack growth kinetics are proposed based on the rate-determining step for the crack growth. The present experimental results can be rationalized by considering multiple element processes such as aqueous mass transport and solid-state mass transport in the crack growth. The cracking mode, the temperature dependence of the crack growth rate, and the transient crack growth behavior for WR 316L SS after changing the environmental temperature are quite similar to those for a cold-worked(CW) 316L SS tested in the same environment, despite their different absolute crack growth rate values. The effect of yield strength on CGR is more significant at lower temperatures and the apparent activation energy for the crack growth rate seems to be lower in the material with a higher yield strength. Time-lag crack growth behavior was found at points during several test steps on WR 316L SS, for example, just after in situ pre-cracking and after increasing or decreasing the temperature, which is quite consistent with the results obtained with CW 316L SS. The importance of in situ monitoring of the crack growth for obtaining steady state crack growth rates is emphasized, especially for those steps for which a nonlinear crack growth period occurs after changing the test condition.\n- A. Simulated boiling-water reactor environment\n- A. Warm-rolled 316L stainless steel\n- C. Apparent thermal activation energy\n- C. Crack growth rate\n- C. Intergranular stress corrosion cracking", "domain": "chemistry", "round": 3} +{"url": "https://k9nerds.com/can-dogs-drink-alkaline-water/", "date": "2024-03-04T01:01:21Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707947476409.38/warc/CC-MAIN-20240304002142-20240304032142-00722.warc.gz", "language_score": 0.9451109170913696, "token_count": 1292, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__132326763", "lang": "en", "text": "You have undoubtedly learned what kinds of foods are excellent for you to consume, how much exercise you need to look and feel well, and most importantly, what kind of water to drink in your quest for a healthier living. You are completely aware of the advantages of alkaline water, cardio exercises, and excellent fat. What about your dog, though? You would have to be concerned for them as well as for your own as a pet owner. Ever wonder if dogs can drink alkaline water? You’ve got the first two covered between the dog park and their premium dog food. What about the water, though, that your dog gleefully downs after every meal or session of play?\nIf you’ve wondered about this, you’ve come to the correct spot because we’re about to answer it and tell you everything we know about it. Because dogs are members of the family, you should pay close attention to what you read.\nAlkaline water is generally safe to drink with your pet best friend. Alkaline water is even thought to boost a dog’s energy levels and enhance the scent of their excrement. But let’s examine whether and when alkaline water is suitable for dogs one step at a time.\nCan Dogs Drink Alkaline Water?\nThe answer is Yes. Dogs can drink alkaline water. The pH range of alkaline water is between 8 and 9, according to the pH scale. On a scale of 0 to 14, the pH level of water, or basically any material, informs you how acidic or alkaline that thing is. Anything below 7 is considered acidic, and anything above 7 is considered alkaline in this situation because 7 is the neutral number.\nWhy You Should Give Your Dog Alkaline Water\nWhat possible advantages might alkaline water provide for canines? Some pet owners assert that their dogs began drinking more water after switching to alkaline water, despite the fact that there isn’t a lot of scientific evidence to back up this assertion. This could be a huge advantage if your dog is prone to dehydration!\nAlkaline water can help your dog feel more energized and have a better metabolism in addition to making them thirsty. That’s because the body may find it simpler to absorb nutrients and hydrate cells when the pH level is higher. Alkaline water could give your dog the energy they need if they’re feeling lethargic.\nAlthough it’s crucial to keep our four-legged pals hydrated, did you know that alkaline water can really treat canine hair loss? Alkaline water can lessen the peeling of acidic sebum, which can cause hair loss, as well as the microbial development that causes alopecia. Alkaline water flushes out dangerous free radicals that are the source of this procedure in addition to everything else. So make sure to give your dog alkaline water to drink if they are beginning to lose their fur.\nAlkaline water can also aid in lessening the odor of your dog’s poop. That’s because scents can be neutralized by the increased pH level. Alkaline water might be worth a shot if you’re sick of cleaning up stinky dog feces.\nWhen Not to Give Alkaline Water to Dogs\nBeing aware of any circumstances that can be bad for your dog’s health is always a smart idea. Check out these suggestions on when not to offer alkaline water to dogs in order to avoid an impromptu trip to the veterinarian and putting your dog through a very unpleasant experience.\n- Avoid providing your dogs with alkaline water along with food.\nAvoid giving your dog alkaline water at least an hour before and an hour after its meal. Since dogs’ stomachs contain powerful hydrochloric acid to digest meat and even bones, adding alkaline water could cause poor digestion after the alkaline water neutralizes the stomach acids.\n- Avoid giving your dog medication-containing alkaline water.\nIt is not advised to combine your dog’s medication with alkaline water because it supports the dog’s metabolism. This implies that drinking alkaline water will hasten digestion and incorporate the medication in this process. Rushing the administration of medication won’t work because it must enter the body at a medically approved rate.\n- Avoid giving alkaline water to a dog that is breastfeeding.\nVeterinarians advise only using filtered water on lactating dogs. Due to the greater amounts of calcium absorption during nursing, providing a nursing dog with alkaline water may result in calciuria (the presence of calcium in their urine).\nWhat is the best alkaline water for dogs?\nThere is no specific best alkaline water for dogs. Dogs generally do not require alkaline water, and providing them with clean, fresh tap water is sufficient for their hydration needs.\nWhat is the best water for dogs to drink?\nThe best water for dogs to drink is clean, fresh water. Tap water that meets the quality standards for human consumption is typically safe for dogs as well. It is important to ensure that the water is free from contaminants and regularly replenished.\nWho should not drink alkaline water?\nAlkaline water may not be suitable for individuals with certain health conditions, such as those with kidney problems or those who are on medications that affect pH balance. It is advisable to consult with a healthcare professional for personalized guidance.\nWhat bottled water is safe for dogs?\nMany brands of bottled water are safe for dogs to drink. Look for bottled water that is labeled as purified or filtered, without any added flavors, minerals, or electrolytes. Ensure the water is free from contaminants and suitable for human consumption.\nCan alkaline water cause bladder stones in dogs?\nThere is no definitive evidence to suggest that alkaline water directly causes bladder stones in dogs. However, maintaining a balanced diet and consulting with a veterinarian are crucial for a dog’s overall urinary health.\nAlthough studies have not yet provided conclusive proof of these claims, alkaline water has the ability to reduce inflammation, enhance digestion, and strengthen the immune system in canines. In case there are any severe medical interactions, it is a good idea to consult your veterinarian before giving your pet alkaline water.", "domain": "chemistry", "round": 3} +{"url": "http://datingbestyz.date/onlinedatingsites-potassium-argon-dating-used-for-9182", "date": "2018-05-28T05:05:23Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-22/segments/1526794871918.99/warc/CC-MAIN-20180528044215-20180528064215-00199.warc.gz", "language_score": 0.9128667712211609, "token_count": 271, "dump": "CC-MAIN-2018-22", "global_id": "webtext-fineweb__CC-MAIN-2018-22__0__196763287", "lang": "en", "text": "Potassium-Argon and Argon-Argon Dating of Crustal Rocks and the. Now, we proudly can say that we have such precise tool, which can pinpoint the actual date of an artifact. Different dating technologies are named after the different process used and the material involved in it. Potassium-Argon and Argon-Argon Dating of Crustal Rocks and the Problem of. tourmaline, albite, and spodumene.7 The Ar-Ar method has also been used to.\nPotassium Argon Dating Argon For example carbon isotopes are used for dating purpose then the dating que required its name to be Carbon-14 or simply C-14 dating. Potassium-Argon Dating. A radioactive counting que used to date the age of geological formations which are associated with fossil remains of early hominid\nDating Methods Using Radioactive Isotopes Since our dating que is named Potassium-Argon dating Why do we need Potassium-Argon or K-Ar dating while another dating ques such as C-14 work just fine. Potassium-argon method. There is another often used dating que for samples considerably older than 60,000 years. It is ed potassium-argon dating.\nPotassium argon dating used for:\nRating: 96 / 100\nOverall: 90 Rates", "domain": "chemistry", "round": 3} +{"url": "http://healthyguide.info/immunoelectron-microscopy-is-a-robust-tool-to-review-biological-molecules-in/", "date": "2024-04-17T05:44:07Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712296817144.49/warc/CC-MAIN-20240417044411-20240417074411-00035.warc.gz", "language_score": 0.9116766452789307, "token_count": 982, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__53187256", "lang": "en", "text": "Immunoelectron microscopy is a robust tool to review biological molecules in the subcellular level. because labeling occurs on parts of set cells where antigens are easier accessible. Over time a true amount of adjustments possess improved the post-embedding solutions to improve immunoreactivity also to keep ultrastructure3-5. Tissue fixation can be a crucial section of EM research. Fixatives crosslink the macromolecules to lock the cells constructions set up chemically. The decision of fixative affects not merely structural preservation but antigenicity and contrast also. Osmium tetroxide (OsO4) formaldehyde and glutaraldehyde have already been the typical fixatives for many years including for central anxious system (CNS) cells that are specially susceptible to structural harm during chemical substance and physical digesting. Unfortunately OsO4 is highly offers and reactive been proven to face mask antigens6 leading to poor and insufficient labeling. Alternative methods to prevent chemical fixation consist of freezing the cells. Bavisant dihydrochloride hydrate But these methods are difficult to execute and require costly instrumentation. To handle a few of these complications also to improve CNS cells labeling Phend viral shot medications) place the membrane with organotypic hippocampal pieces inside a 60 x Bavisant dihydrochloride hydrate 15 mm polystyrene Petri dish including ice-cold 0.1 M phosphate buffer (Sorensen’s phosphate buffer) pH 7.3. Add 1 – 2 ml of 0.1 M phosphate Bavisant dihydrochloride hydrate buffer on best of the slices to maintain them cool directly. CRITICAL Stage: Always utilize freshly ready buffers and fixatives. Make certain the pH of buffer is at desired range. Failing to take action could harm cellular structures.medications or viral disease the membrane containing the cut was put into ice-cold phosphate buffer. The cut was first lower horizontally under the dentate gyrus (DG) parallel towards the CA1 cell coating. The CA1 subfield was after Bavisant dihydrochloride hydrate that isolated by detatching the CA3 subfield as well as the subiculum (sub). To greatly help identify the very best surface from the CA1 Bavisant dihydrochloride hydrate a part was cut to orient the cells (in cases like this the upper correct hand part). Shape 2. Immunogold labeling of neurogranin at CA1 synapses in organotypic hippocampal cut cultures. (A) Transmitting electron micrographs displaying rat hippocampal CA1 region and synapses. Dendrites (d) of CA1 pyramidal neurons are often distinguishable. Recognition of asymmetrical synapses between axonal terminal 9t) and dendritic spines (s) can be facilitated by the current presence of post-synaptic denseness (PSD arrowhead) and well-defined plasma membrane. (B) Distribution of neurogranin (Ng) in dendritic spines. got demonstrated that TA UA and PPD also improved structural preservation (discover Shape 1 of the initial Phend paper)7 which efficient immunostaining CCR7 was found out for multiple protein including element P calcitonin gene-related peptide (CGRP) AMPA receptor subunit 1 (GluA1) and gamma-aminobutyric acidity (GABA)7. These results demonstrate the ability of this treatment to review different protein in neuronal cells. Another benefit of this method can be that TA UA and PPD are easy to get ready and deal with and pose very much smaller hazardous dangers than osmium which is incredibly volatile and incredibly poisonous by inhalation and pores and skin contact. One restriction of this technique is that though it preserves and retains little antigens such as for example amino acids it generally does not display improved immunolabeling for these substances compared to regular osmium treatment. The benefit of the rock platinum chloride to protect structure also to improve immunoreactivity also appears to be limited by the spinal-cord for reasons that aren’t completely realized7. Even though the osmium-free method boosts antigenicity and cells contrast it generally does not seem to work very well for the preservation of additional structures such as for example presynaptic vesicles (discover Figure 2). Furthermore Phend had noticed that the lack of osmium also led to decreased myelin preservation as TA offers limited penetrability in to the intracellular parts to protect membranes7. Therefore freezing options for specimen planning could be better alternatives if ultrastructural preservation may be the most significant concern. Ultrarapid freezing of specimen enables the preservation of substances in a far more natural method18 without potential.", "domain": "chemistry", "round": 3} +{"url": "https://bv.fapesp.br/en/bolsas/159465/microbial-metagenomics-for-identification-of-microviridin-encoding-genes-from-brazilian-cyanobacteri/", "date": "2023-12-10T19:25:52Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679102637.84/warc/CC-MAIN-20231210190744-20231210220744-00019.warc.gz", "language_score": 0.8611218333244324, "token_count": 423, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__40175303", "lang": "en", "text": "Cyanobacteria have recently been rediscovered as proficient producers of bioactive secondary metabolites, in special, polyketides, alkaloids and peptides. Noteworthy are the peptides produced by megasyntethases (microcystins, nodularin, aeruginosina) or ribosomally (microviridins, cyanobactins, lantipeptides). Microviridins belong to a new class of depsipeptides horbouring a unique cage-like tricyclic structure. Due to their inhibitory activity against proteases, microviridins have high potential in drug design, notably for the treatment of protease-related-diseases, e.g., pulmonary emphysema, cystic fibrosis or infection. Up to now, 13 microviridins derivatives have been discovered. However, metagenomics studies revealed an unexpected cryptic genetic diversity of microviridins in field samples. In the last decades, metagenomics has rapidly developed into an efficient culture-independent approach, allowing to access any gene sequence or function of a given environmental sample. Metagenomics offers powerfull and modern tools to characterise genes, gene clusters and the production metabolites from complex samples, such as cyanobacterial blooms. These metacomunity harbours a huge genetic diversity, mostly cryptic, for the production of bioactive secondary metabolites. Metagenomic mining studies of a number of environmental cyanobacterial samples have revealed a surprising gene variability for the synthesis of microviridins, expanding the natural library of these tricyclic peptides. This research project is part of the post-doctoral research plan \"Expanding the natural library microviridins through metagenomic data mining techniques of cyanobacteria in Brazilian biomes\" (Process FAPESP nr.: 2013 / 50755-8) aimed at prospecting cryptic microviridins in isolated strains and cyanobacterial blooms from Brazilian biomes.\nNews published in Agência FAPESP Newsletter about the scholarship:", "domain": "chemistry", "round": 3} +{"url": "https://www.ias.ac.in/describe/article/jcsc/100/05/0425-0431", "date": "2022-12-08T08:54:04Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-49/segments/1669446711286.17/warc/CC-MAIN-20221208082315-20221208112315-00637.warc.gz", "language_score": 0.8922615051269531, "token_count": 251, "dump": "CC-MAIN-2022-49", "global_id": "webtext-fineweb__CC-MAIN-2022-49__0__196296201", "lang": "en", "text": "Mixed ligand complexes of Cu(II) with 8-hydroxy-quinolinate (Hy) as one ligand and acetylacetonate (ac.ac) or salicylaldehydate (Sal) as the second ligand have been prepared in reaction mixtures of Cu(Hy)2 + Cu(ac.ac)2 and Cu(Hy)2 + Cu(Sal)2 in chloroform. Ligand hyperfine structures and the minimum ESR linewidth associated withm = − 3/2 hyperfine component have been used to detect and identify the mixed ligand complexes. The ligands in these complexes coordinate through O or N. The constantsK associated with the ligand exchange equilibriums are ~ 2 at −20°C and are close to the value expected from the empirical relation obtained in an earlier work from a study of Cu(II) complexes in which S also participates in the coordination.\nVolume 134, 2022\nContinuous Article Publishing mode\nClick here for Editorial Note on CAP Mode", "domain": "chemistry", "round": 3} +{"url": "https://www.tcichemicals.com/TH/en/p/N0140", "date": "2022-08-18T16:17:53Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882573242.55/warc/CC-MAIN-20220818154820-20220818184820-00275.warc.gz", "language_score": 0.7814497947692871, "token_count": 673, "dump": "CC-MAIN-2022-33", "global_id": "webtext-fineweb__CC-MAIN-2022-33__0__173906690", "lang": "en", "text": "CAS RN: 138-42-1 | Product Number: N0140\n|Size||Unit Price||Same Day||2-3 Business Days|\nPreviously this product had been labeled as a hydrate form both in product name and molecular formula. The hydrate form had no exclusive CAS RN and used to share the same CAS RN as the anhydrous form.\nTo avoid any misleading information and since moisture in product is considered as an impurity, we have decided to remove the term 'Hydrate' from product name and 'xH2O' from the molecular formula for such products.\nPlease use it at ease since there is no difference in product quality, even if you see the previous indications on a part of label.\n|Appearance||White to Light yellow powder to crystal|\n|Purity(HPLC)||min. 98.0 area%|\n|Purity(Neutralization titration)||min. 98.0 %(calcd.on anh.substance)|\n|Melting point||111.0 to 115.0 °C|\n|Water||14.0 to 19.0 %|\n|Melting Point||95 °C|\n|Solubility in water||Soluble|\n|Hazard Statements||H314 : Causes severe skin burns and eye damage.\n|Precautionary Statements||P501 : Dispose of contents/ container to an approved waste disposal plant.\nP260 : Do not breathe dusts or mists.\nP264 : Wash skin thoroughly after handling.\nP280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.\nP303 + P361 + P353 : IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/shower.\nP301 + P330 + P331 : IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.\nP363 : Wash contaminated clothing before reuse.\nP304 + P340 + P310 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/doctor.\nP305 + P351 + P338 + P310 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER/doctor.\nP405 : Store locked up.\nSafety Data Sheet (SDS)\nThe requested SDS is not available.\nPlease Contact Us for more information.\nC of A & Other Certificates\nThe requested analytical chart is not available. Sorry for the inconvenience.", "domain": "chemistry", "round": 3} +{"url": "https://scholars.uow.edu.au/display/publication32174", "date": "2022-11-29T10:29:43Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-49/segments/1669446710691.77/warc/CC-MAIN-20221129100233-20221129130233-00321.warc.gz", "language_score": 0.9246300458908081, "token_count": 386, "dump": "CC-MAIN-2022-49", "global_id": "webtext-fineweb__CC-MAIN-2022-49__0__109360842", "lang": "en", "text": "In vertebrates, fibrinolysis is primarily carried out by the serine protease plasmin (Pm), which is derived from activation of the zymogen precursor, plasminogen (Pg). One of the most distinctive features of Pg/Pm is the presence of five homologous kringle (K) domains. These structural elements possess conserved Lys-binding sites (LBS) that facilitate interactions with substrates, activators, inhibitors and receptors. In human Pg (hPg), K2 displays weak Lys affinity, however the LBS of this domain has been implicated in an atypical interaction with the N-terminal region of a bacterial surface protein known as PAM (Pg-binding group A streptococcal M-like protein). A direct correlation has been established between invasiveness of group A streptococci and their ability to bind Pg. It has been previously demonstrated that a 30-residue internal peptide (VEK-30) from the N-terminal region of PAM competitively inhibits binding of the full-length parent protein to Pg. We have attempted to determine the effects of this ligand-protein interaction on the regulation of Pg zymogen activation and conformation. Our results show minimal effects on the sedimentation velocity coefficients (S degrees (20,w)) of Pg when associated to VEK-30 and a direct relationship between the concentration of VEK-30 or PAM and the activation rate of Pg. These results are in contrast with the major conformational changes elicited by small-molecule activators of Pg, and point towards a novel mechanism of Pg activation that may underlie group A streptococcal (GAS) virulence. (C) 2010 Elsevier B.V. All rights reserved.", "domain": "chemistry", "round": 3} +{"url": "http://circ.ahajournals.org/content/116/Suppl_16/II_105.4", "date": "2018-05-23T22:07:42Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-22/segments/1526794865830.35/warc/CC-MAIN-20180523215608-20180523235608-00154.warc.gz", "language_score": 0.8821879029273987, "token_count": 472, "dump": "CC-MAIN-2018-22", "global_id": "webtext-fineweb__CC-MAIN-2018-22__0__132549662", "lang": "en", "text": "Abstract 582: A Novel PPARδ-Hepatic Lipase Transcriptional Pathway\nPPARδ is a fatty acid responsive transcription factor that critically regulates lipid metabolism, energy balance and atherosclerosis. Despite extensive characterization of PPARδ responses induced by pharmacologic agents, the identity of endogenous ligands for PPAR activation remains a central unresolved issue in this field. We have previously identified that lipoprotein lipase (LPL) hydrolysis of VLDL and endothelial lipase (EL) hydrolysis of HDL can liberate PPARδ activators and regulate PPARδ responsive genes in a selective manner. This working model implicates lipoprotein metabolism as a putative source for PPAR activation. Hepatic Lipase (HL) is a third member of this triacylglycerol lipase family that regulates both HDL and VLDL metabolism. We hypothesized that HL also activates PPAR transcriptional responses. Here, we report a novel role for HL in PPAR transcription by demonstrating that HL activates PPARδ through hydrolysis of VLDL. Employing a PPAR-LBD/GAL-4 luciferase heterologous transcriptional reporter system, we demonstrate that HL activated PPARδ selectively, with miminal PPARδ activation and no PPARδ activation. In light of HL’s known phospholipase and triglyceride hydrolase activity, we next determined the role of HDL and VLDL in HL-mediated PPARδ activation. We found that VLDL is the preferred substrate for this HL/PPARδ pathway. In addition, heparin, an established activator of HL, markedly augmented HL-mediated activation of PPARδ, and pre-treatment of cells with tetrahydrolipstatin, a general lipase inhibitor, abrogated HL-mediated PPARδ stimulation. Finally, we have demonstrated that HL mediated VLDL hydrolysis enhances PLTP gene expression, a known PPARδ target. Taken together these data identify a novel pathway for PPARδ transcriptional activation through HL-mediated VLDL hydrolysis and implicate PPARδ as a central integrator of lipoprotein metabolism.", "domain": "chemistry", "round": 3} +{"url": "http://zdrave.expert/zdrave-forte/zdrave-forte-intensive-shampoo-for-seborrhea", "date": "2021-11-30T15:46:57Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-49/segments/1637964359037.96/warc/CC-MAIN-20211130141247-20211130171247-00485.warc.gz", "language_score": 0.7804016470909119, "token_count": 360, "dump": "CC-MAIN-2021-49", "global_id": "webtext-fineweb__CC-MAIN-2021-49__0__92668278", "lang": "en", "text": "Zdrave Forte intensive shampoo for seborrhea is an intensive product created for cases of severe dandruff and seborrhea, accompanied by itching and redness of the scalp. It contains two complementary and enhancing their effect ingredients – Cade oil and Octopirox. Their original combination provides for proper cleaning of the scalp and for regulating sebum secretion. Shampoo soothes redness due to its formula with close to the physiological pH. It cleans the scalp in depth and gives hair shine, elasticity and strength.\nWet hair thoroughly. Apply shampoo, rub well and let it work for about 3 minutes. Rinse thoroughly with water. Reapply if necessary. Use the shampoo 2-3 times a week for one month. Continue to use once a week.\nAQUA, SODIUM LAURETH SULFATE, SODIUM COCOAMPHOACETATE, DISODIUM LAURETH SULFOSUCCINATE, DECYL GLUCOSIDE, POLYQUATERNIUM-44, PEG-18 GLYCERYL OLEATE / COCOATE, GLYCERETH-2 COCOATE, PEG-40 HYDROGENATED CASTOR OIL, TRIDECETH-9, GLYCERIN, PANTENOL, NIACINAMIDE, JUNIPERUS OXYCEDRUS WOOD TAR, PIROCTONE OLAMINE, BISABOLOL, CITRIC ACID, METHYLCHLOROISOTHIAZOLINONE, METHYLISOTHIAZOLINONE, BENZYL ALCOHOL", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/clk4-antibody-ab67936.html", "date": "2020-09-19T13:20:32Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-40/segments/1600400191780.21/warc/CC-MAIN-20200919110805-20200919140805-00578.warc.gz", "language_score": 0.7599695324897766, "token_count": 543, "dump": "CC-MAIN-2020-40", "global_id": "webtext-fineweb__CC-MAIN-2020-40__0__29775250", "lang": "en", "text": "Key features and details\n- Mouse polyclonal to CLK4\n- Suitable for: WB\n- Reacts with: Human\n- Isotype: IgG\nStorage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.\nStorage bufferpH: 7.4\nConstituent: 2.68% PBS\nConcentration information loading...\nPurityProtein G purified\nOur Abpromise guarantee covers the use of ab67936 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\n|WB||1/500 - 1/1000. Detects a band of approximately 62 kDa (predicted molecular weight: 57 kDa).|\nFunctionDual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates SRSF1 and SRSF3. Required for the regulation of alternative splicing of MAPT/TAU. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells.\nTissue specificityExpressed in liver, kidney, heart, muscle, brain and endothelial cells.\nSequence similaritiesBelongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily.\nContains 1 protein kinase domain.\nmodificationsAutophosphorylates on all three types of residues.\n- Information by UniProt\n- AI987988 antibody\n- C85119 antibody\n- CDC like kinase 4 antibody\nAll lanes : Anti-CLK4 antibody (ab67936) at 1/500 dilution\nLane 1 : CLK4 transfected 293T cell lysate\nLane 2 : non transfected 293T cell lysate\nLysates/proteins at 25 µg per lane.\nAll lanes : Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution\nPredicted band size: 57 kDa\nObserved band size: 62 kDa why is the actual band size different from the predicted?\nab67936 has not yet been referenced specifically in any publications.", "domain": "chemistry", "round": 3} +{"url": "https://manualzz.com/doc/o/2jd2m2/graco-313997p---hfr-owner-s-manual-flushing", "date": "2024-04-24T11:48:50Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712296819273.90/warc/CC-MAIN-20240424112049-20240424142049-00455.warc.gz", "language_score": 0.8229102492332458, "token_count": 394, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__194838508", "lang": "en", "text": "Flushing. Graco 313997P - HFRAdd to my manuals\nFlush equipment only in a well-ventilated area. Do not dispense flammable fluids. Do not turn on heaters while flushing with flammable solvents.\n• Flush out old fluid with new fluid, or flush out old fluid with a compatible solvent before introducing new fluid.\n• Use the lowest possible pressure when flushing.\n• All fluid components are compatible with common solvents. Use only moisture-free solvents. See\nponents to verify compatibility of solvent with wetted materials. See solvent manufacturers information for material compatibility.\n• To flush feed hoses, pumps, and heaters separately from heated hoses, set PRESSURE RELIEF/DIS-\nPENSE valves (SA, SB) to PRESSURE\n• To maintain grounding continuity when flushing or relieving pressure, hold a metal part of dispense gun firmly to the side of a grounded metal pail, then trigger gun.\nRELIEF/CIRCULATION lines (N).\n. Flush through bleed\n• To flush entire system, circulate through gun fluid manifold (with manifold removed from gun).\n• To prevent moisture from reacting with isocyanate, always leave the system dry or filled with a moisture-free plasticizer or oil. Do not use water. See\n• Solvent pails used when flushing : follow your local code. Use only metal pails, which are conductive, placed on a grounded surface. Do not place pail on a nonconductive surface, such as paper or cardboard, which interrupts grounding continuity.\n* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project", "domain": "chemistry", "round": 3} +{"url": "https://www.cheric.org/research/tech/periodicals/view.php?seq=1740467", "date": "2020-08-07T16:03:18Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-34/segments/1596439737204.32/warc/CC-MAIN-20200807143225-20200807173225-00386.warc.gz", "language_score": 0.8456642627716064, "token_count": 402, "dump": "CC-MAIN-2020-34", "global_id": "webtext-fineweb__CC-MAIN-2020-34__0__35773508", "lang": "en", "text": "Biochemical and Biophysical Research Communications, Vol.515, No.1, 31-36, 2019\nAminophylline promotes mitochondrial biogenesis in human pulmonary bronchial epithelial cells\nRecently, mitochondrial dysfunction has been linked to the development of common airway disorders, such as chronic obstructive pulmonary disease (COPD) and asthma. Phosphodiesterase inhibitors are therapeutic agents for various diseases. Aminophylline is a nonselective phosphodiesterase inhibitor used to treat common lung diseases. In this study, we show that aminophylline promotes mitochondrial biogenesis in cultured human pulmonary bronchial epithelial cells (HPBECs). Aminophylline treatment induces the expression of transcriptional coactivator PGC-1 alpha and transcriptional factors NRF1 and TFAM. The effect of aminophylline on mitochondrial biogenesis can be revealed by its promotion of the ratio of mitochondrial DNA to nuclear DNA (mtDNA/nDNA), mitochondrial protein cytochrome B and mitochondrial mass. At the cellular level, aminophylline increases the mitochondrial respiration rate and ATP production but reduces oxygen content. Consistently, we show that aminophylline activates the CREB-PGC-1 alpha signaling pathway to promote mitochondrial biogenesis. The inhibition of CREB activation by its specific inhibitor H89 obscures the induction of PGC-1 alpha, NRF1, and TFAM by aminophylline, and also abolishes the action of aminophylline on the mtDNA/nDNA ratio and respiration rate, suggesting that the activation of CREB is required for the action of aminophylline. Collectively, our study supports that aminophylline is a potent metabolic inducer of mitochondrial biogenesis in epithelial cells. Aminophylline could have a therapeutic effect on epithelial mitochondrial function in lung diseases. (C) 2019 Published by Elsevier Inc.", "domain": "chemistry", "round": 3} +{"url": "https://www.hindawi.com/journals/jchem/2012/646397/", "date": "2022-01-20T12:23:54Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-05/segments/1642320301737.47/warc/CC-MAIN-20220120100127-20220120130127-00202.warc.gz", "language_score": 0.8117017149925232, "token_count": 250, "dump": "CC-MAIN-2022-05", "global_id": "webtext-fineweb__CC-MAIN-2022-05__0__117757157", "lang": "en", "text": "Satyendra N. Shukla, Pratiksha Gaur, Ripul Mehrotra, Radhey S. Srivastava, \"Experiences during Synthesis of a Dinucleating Spacer Incorporating 2-Chloropyridine Units Through Sandmayer Reaction\", Journal of Chemistry, vol. 9, Article ID 646397, 5 pages, 2012. https://doi.org/10.1155/2012/646397\nExperiences during Synthesis of a Dinucleating Spacer Incorporating 2-Chloropyridine Units Through Sandmayer Reaction\nA bimetallic cuprous complex was accidentally reported, during synthesis of a dinucleating spacer incorporating two 2-chloropyridine units through Sandmayer reaction. The product was characterized by elemental analysis, FAB-Mass, FT-IR, UV, magnetic susceptibility and 1H-NMR spectroscopic method. A possible mechanism is also proposed.\nCopyright © 2012 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.", "domain": "chemistry", "round": 3} +{"url": "https://korean-wallpaper.com/quality-natural-garnet-for-sandblast-waterjet-cutting-water-treatment/", "date": "2022-12-09T11:53:03Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-49/segments/1669446711396.19/warc/CC-MAIN-20221209112528-20221209142528-00197.warc.gz", "language_score": 0.7980597019195557, "token_count": 780, "dump": "CC-MAIN-2022-49", "global_id": "webtext-fineweb__CC-MAIN-2022-49__0__60466113", "lang": "en", "text": "Large High quality All-natural XiHu (West Lake) Dis.Hu (West Lake) Dis.web Sand Abrasive for Sandblasting/WaterEPT Chopping/Drinking water Remedy\nThe distinct gravity of XiHu (West Lake) Dis.Hu (West Lake) Dis.internet is three.96g/cm3. The main interior composition of XiHu (West Lake) Dis.Hu (West Lake) Dis.net is crystallized iron and alumina. It is suited for free of charge lapping or becoming utilized for creating natural and organic bonded abrasive equipment. It also has non-abrasive software. Sizzling Sale 60# eighty#.. natural XiHu (West Lake) Dis.Hu (West Lake) Dis.internet sand with substantial quality large efficiency excellent rates.\nNatural XiHu (West Lake) Dis.Hu (West Lake) Dis.web sand have the qualities of large hardness, higher temperature resistance, stable chemical qualities, uniform particles, high grinding efficiency and no scratches, ideal for waterEPT chopping sector, sandblasting and h2o treatment.\nAll sizes accessible, twenty/40#, thirty/sixty#, sixty#, 80#, a hundred#, a hundred and twenty#, one hundred fifty#, 200#, and many others.\n|Product||Chemical composition(%,by bodyweight)|\n|XiHu (West Lake) Dis.Hu (West Lake) Dis.internet||35.-forty.||twenty.-28.||25.-27.||5.-10.|\nObserve: Specific requirements on chemical composition and other terms can be happy by means of discussion.\nXiHu (West Lake) Dis.Hu (West Lake) Dis.Internet – WaterEPT Chopping\n80# (A, A+)\nUtilization: This design of XiHu (West Lake) Dis.Hu (West Lake) Dis.net is widely employed in EPT-shaped processing of various of steel supplies, just like stainless metal, aluminum, carbon steel plate, metal, EPTium alloy,and so on. It can also utilized in cutting procedure for tile, stone, rubber, glass, wood, etc.\nEffect: As the most generally used water slicing abrasive, the XiHu (West Lake) Dis.Hu (West Lake) Dis.web of this product can attain a excellent balance in between the cutting velocity and the large precision of chopping face.\none hundred twenty# (A+), 200# (A+)\nUsage: This type of XiHu (West Lake) Dis.Hu (West Lake) Dis.web is often used in slicing processing of EPT applied glass, cell screen and semiconductor.\nImpact: PoXiHu (West Lake) Dis.Hu (West Lake) Dis.ng is not necessary, due to the fact the XiHu (West Lake) Dis.Hu (West Lake) Dis.web for this grit can make a large precision slicing with quite low tolerance, even when it comes to the mesh concluded merchandise.\n|Product Model||Grade||Particle Dimension Range||Sand Tube Diameter|\n|80#||A Course||.fifteen-.355mm||.762mm, 1.02mm, one.27mm|\n|a hundred and twenty#||A+ Course||.1-.2mm||.508mm,.762mm|\nNote: Particular demands on any conditions can be content by way of dialogue.", "domain": "chemistry", "round": 3} +{"url": "https://rego2oil.castrol.com/en_au/australia/vehicle/11_Lawn_Mowers_Ride_On_Including_Garden_Tractors_/863_TORO_WHEEL_HORSE_RIDE_ON_/30407_Sand_Pro_5040_18_h_p_Vanguard_V_twin_Eng_Hydrostatic_Trans_", "date": "2020-10-30T19:45:02Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-45/segments/1603107911229.96/warc/CC-MAIN-20201030182757-20201030212757-00186.warc.gz", "language_score": 0.7883946299552917, "token_count": 519, "dump": "CC-MAIN-2020-45", "global_id": "webtext-fineweb__CC-MAIN-2020-45__0__209415006", "lang": "en", "text": "TORO (WHEEL HORSE) [RIDE-ON] Sand Pro 504018 h.p. Vanguard V-twin Eng., Hydrostatic Trans.\nEngineService Refill Capacity: 1.7* Litres (Includes oil filter)\nCASTROL EDGE 5W-30 A3/B4 best\nCastrol EDGE 5W-30 A3/B4 with Fluid TITANIUM is the natural choice for drivers who demand maximum engine performance from today’s modern vehicles requiring a high level of protection and higher performance oils.Today’s engines continually push the boundaries of technology and engineering. They are smaller and ultra-efficient, without sacrificing performance. It transforms its physical structure to be stronger under pressure to keep metal surfaces apart and reduces friction for maximum engine performance when you need it most.Suitable for use in automotive petrol and diesel vehicles, where the manufacturer recommends an ACEA A3/B4, API SL/CF or earlier specification 5W-30 lubricant.\nCASTROL MAGNATEC STOP-START 10W-30 better\nDo you drive in busy traffic? Choose Castrol MAGNATEC STOP-START 10W-30 part synthetic engine oil. The Intelligent Molecules will protect your engine from the moment you start, every time you start, dramatically reducing stop-start wear (versus industry limit in the OM646LA engine test). Suitable for use in automotive petrol and diesel engines where the manufacturer recommends an API SN, ACEA A3/B3, A3/B4 or earlier specification 10W-30 lubricant.\nCASTROL GARDEN 4T 10W-30 good\nHydraulicService Refill Capacity: 18.9 Litres\nCASTROL HYSPIN AWH 46\nA high quality, mineral oil based hydraulic fluid enhanced by incorporating anti-wear, anti-oxidation, anti-foam and anti corrosion additives. The addition of a viscosity index improver enables the product to operate under a wide range of temperatures without loss of viscosity. Meets the requirements of modern hydraulic equipment operating under medium to severe service conditions over a wide temperature range.\nRecommendations are for Passenger Cars Only.\nNot all vehicles will have a recommendation.\nANY QUERIES REGARDING YOUR REGO2OIL LUBRICANT RECOMMENDATION OR FOR FURTHER ASSISTANCE CALL THE CASTROL TECHNICAL HELPLINE ON 1300 557 998", "domain": "chemistry", "round": 3} +{"url": "https://www.karger.com/Article/Abstract/84882", "date": "2017-10-24T03:45:56Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-43/segments/1508187828134.97/warc/CC-MAIN-20171024033919-20171024053919-00599.warc.gz", "language_score": 0.9090840220451355, "token_count": 775, "dump": "CC-MAIN-2017-43", "global_id": "webtext-fineweb__CC-MAIN-2017-43__0__261391505", "lang": "en", "text": "New Synthetic Surfactants: The Next Generation?Pfister R.H. · Soll R.F.\nDepartment of Pediatrics, University of Vermont College of Medicine, Burlington, Vt., USA\nDo you have an account?\n- Rent for 48h to view\n- Buy Cloud Access for unlimited viewing via different devices\n- Synchronizing in the ReadCube Cloud\n- Printing and saving restrictions apply\nRental: USD 8.50\nCloud: USD 20.00\nSurfactant preparations have been proven to improve clinical outcome of infants at risk for or having respiratory distress syndrome (RDS). In clinical trials, ani mal-derived surfactant preparations reduce the risk of pneumothorax and mortality when compared to non-protein-containing synthetic surfactant preparations. In part, this is thought to be due to the presence of surfactant proteins in animal-derived surfactant preparations. Four native surfactant proteins have been identified. The hydrophobic surfactant proteins B (SP-B) and C (SP-C) are tightly bound to phospholipids. These proteins have important roles in maintaining the surface tension-lowering properties of pulmonary surfactant. Surfactant protein A (SP-A) and D (SP-D) are extremely hydrophilic and are not retained in the preparation of any commercial animal-derived surfactant products. These proteins are thought to have a role in recycling surfactant and improving host defense. There is concern that animal-derived products may have some batch-to-batch variation regarding the levels of native pulmonary surfactant proteins. In addition, there is concern regarding the hypothetical risk of transmission of viral or unconventional infectious agents from an animal source. New surfactant preparations, composed of synthetic phospholipids and essential hydrophobic surfactant protein analogs, have been developed. These surfactant protein analogs have been produced by peptide synthesis and recombinant technology to provide a new class of synthetic surfactants that may be a suitable alternative to animal-derived surfactants. Preliminary clinical studies have shown that treatment with these novel surfactant preparations can ameliorate RDS and improve clinical outcome. Clinicians will need to further understand any differences in clinical effects between available products.\n© 2005 S. Karger AG, Basel\nArticle / Publication Details\nCopyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.\nDrug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.\nDisclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.", "domain": "chemistry", "round": 3} +{"url": "https://bicycles.stackexchange.com/questions/16401/how-to-remove-rust-from-unpainted-parts", "date": "2023-12-05T10:10:14Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100550.40/warc/CC-MAIN-20231205073336-20231205103336-00109.warc.gz", "language_score": 0.8753060698509216, "token_count": 314, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__104607068", "lang": "en", "text": "The best way to remove rust from steel or cast iron is by electrolysis, period!\nSee the links below, but a few points need to be emphasized first:\nDO wear rubber, latex or other waterproof gloves\nDO wear old clothes, cuz the solution will stain just about anything!\nDON'T put the solution where it can be kicked or spilled, it will leave a killer stain!\nDON'T hook up what you are removing the rust off to the positive (+) terminal!\nAnd most critically important DON'T USE STAINLESS STEEL AS THE ANODE (+ electrode)!!!\nOk, now to the links that explain the method:\nA few suggestions. Use no more than 6 volts, particularly if you don't want to remove paint. Use washing soda (sodium carbonate, aka NaCO3) as the ingredient, not salt or lye. Small quantities of NaCO3 can be made by heating baking soda spread on a cookie sheet for 300 degrees F (150C) for about 1 hr.\nDon't pour the old liquid on your lawn or garden, the sodium could damage the soil. The solution is safe to pour down a laundry or basement drain, but be sure to wash out the drain afterwards.\nAt most only 1 tbsp per gallon NaCO3 is needed - using more is just a waste.\nIf you use an old wall-wart, the negative is usually the wire bearing a white line or bead on it and is usually hooked to the outside ring on the outlet plug.", "domain": "chemistry", "round": 3} +{"url": "https://news.thomasnet.com/fullstory/flue-gas-analyzer-helps-reduce-greenhouse-gases-819739", "date": "2021-01-24T22:28:05Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-04/segments/1610703557462.87/warc/CC-MAIN-20210124204052-20210124234052-00666.warc.gz", "language_score": 0.9087361693382263, "token_count": 870, "dump": "CC-MAIN-2021-04", "global_id": "webtext-fineweb__CC-MAIN-2021-04__0__107465740", "lang": "en", "text": "Press Release Summary:\nDesigned for large industrial boilers and furnaces, Rosemount Analytical X-STREAM® Oxygen Analyzer features AccuMax(TM) accuracy specifications, extended temperature capability, and probe lengths of up to 18 ft. In situ combustion flue gas analyzer provides information to control fuel-to-air ratio of burner as well as indication of stratification of flue gases inside the furnace. It can be adjusted after installation and repaired without removing probe from furnace duct.\nOriginal Press Release:\nEmerson's Enhanced Flue Gas Analyzers Help Improve Combustion Efficiency, Reduce Greenhouse Gases\nX-STREAM® Oxygen Analyzer's extended, adjustable probe length enables more accurate readings for large boilers and furnaces\nSOLON, OHIO (August 12, 2008) - Emerson Process Management has enhanced its Rosemount Analytical X-STREAM® Oxygen Analyzers to improve efficiencies of large boilers and furnaces and provide immediate reduction of carbon dioxide (CO2) emissions with minimal investment.\nLarge industrial boilers and furnaces are primary generators of the greenhouse gas CO2. Rosemount Analytical X-STREAM O2 in situ combustion flue gas analyzers are a key tool for optimizing combustion, and reducing emissions. These analyzers provide information to control the fuel-to-air ratio of the burner, much in the same way it's done on today's automobiles. The X-STREAM O2 probe now offers improved AccuMax(TM) accuracy specifications, extended temperature capability, and new longer probe lengths up to 18 feet long to satisfy the need of the industry's biggest boilers and furnaces.\nAccording to Doug Simmers, worldwide product manager for Rosemount Analytical, large furnaces will typically have many burners delivering fuel and air into the combustion zone, which may be the size of a 10 story office building. Balancing the burners maximizes heat rate efficiency, and also minimizes the potential damage to the furnace from flame impingement, tube leaks, excessive soot, slagging, and many other potential operational problems.\nTo achieve balance and avoid these problems, many facilities use permanently mounted O2 probes at different locations inside the flue gas duct and average the readings inside the control system to optimize the total furnace fuel-to-air-ratio. Readings from the O2 probes also provide an indication of the stratification of flue gases inside the furnace.\n\"Many traditional O2 analyzers have had a fixed insertion depth, and engineers have had to guess at the best placement of the probes,\" Simmers explained. \"The new longer probes from Rosemount Analytical not only reach further into these large ducts, but they now have the ability to be adjusted after installation so that the entire width of the flue gas duct can be characterized.\"\nThe X-STREAM line of combustion O2 probes offer long life in this difficult service, and are now designed to be repaired without removing the probe from the furnace duct. Additionally, they can provide indication of reducing conditions that may occur inside the furnace during plant upsets.\nMore information about the Rosemount Analytical line of X-STREAM O2 analyzers can be found at http://emersonprocess.com/raihome/gas/products/Model_XS-O2.asp.\nAbout Emerson Process Management\nEmerson Process Management (www.EmersonProcess.com), an Emerson business, is a leader in helping businesses automate their production, processing and distribution in the chemical, oil and gas, refining, pulp and paper, power, water and wastewater treatment, metals and mining, food and beverage, pharmaceutical and other industries. The company combines superior products and technology with industry-specific engineering, consulting, project management and maintenance services. Its brands include PlantWeb®, Fisher®, Micro Motion®, Rosemount®, Daniel®, DeltaV(TM), Ovation®, and AMS® Suite.\nEmerson, based in St. Louis, is a global leader in bringing technology and engineering together to provide innovative solutions to customers through its network power, process management, industrial automation, climate technologies, and appliance and tools businesses.\nFor more information, visit www.Emerson.com.", "domain": "chemistry", "round": 3} +{"url": "https://www.climate-policy-watcher.org/energy-industries/for-carbon-dioxide.html", "date": "2020-06-02T15:16:06Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-24/segments/1590347425148.64/warc/CC-MAIN-20200602130925-20200602160925-00330.warc.gz", "language_score": 0.8877554535865784, "token_count": 250, "dump": "CC-MAIN-2020-24", "global_id": "webtext-fineweb__CC-MAIN-2020-24__0__183867839", "lang": "en", "text": "Fuel combustion refers to fossil fuel combustion and the unstored fraction of non-energy/feedstock use (IPCC Source/Sink Category 1A) estimated using the IPCC Sectoral Approach from the Revised 1996 IPCC Guidelines (see Part I).\nFugitive refers to flaring of associated gas in oil and gas production (including indirect CO2 from methane venting) (IPCC Source/Sink Category 1B).\nIndustrial Processes refers to production of cement, lime, soda ash, carbides, ammonia, urea, methanol and ferrous metals and to the use of soda ash, limestone and dolomite (IPCC Source/Sink Category 2).\nOther refers to direct emissions from forest fires and peat fires plus emissions from decay (decomposition) of aboveground biomass that remains after logging\nWas this article helpful?\nYour Alternative Fuel Solution for Saving Money, Reducing Oil Dependency, and Helping the Planet. Ethanol is an alternative to gasoline. The use of ethanol has been demonstrated to reduce greenhouse emissions slightly as compared to gasoline. Through this ebook, you are going to learn what you will need to know why choosing an alternative fuel may benefit you and your future.", "domain": "chemistry", "round": 3} +{"url": "https://www.fhwa.dot.gov/publications/research/infrastructure/pavements/ltpp/reports/01097/references.cfm", "date": "2017-04-24T03:33:20Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-17/segments/1492917118963.4/warc/CC-MAIN-20170423031158-00075-ip-10-145-167-34.ec2.internal.warc.gz", "language_score": 0.7605458498001099, "token_count": 358, "dump": "CC-MAIN-2017-17", "global_id": "webtext-fineweb__CC-MAIN-2017-17__0__74946285", "lang": "en", "text": "U.S. Department of Transportation\nFederal Highway Administration\n1200 New Jersey Avenue, SE\nWashington, DC 20590\nFederal Highway Administration Research and Technology\nCoordinating, Developing, and Delivering Highway Transportation Innovations\n|This report is an archived publication and may contain dated technical, contact, and link information\nPublication Number: FHWA-RD-01-097\nDate: January, 2002\nLong-Term Performance of Corrosion Inhibitors Used in Repair of Reinforced Concrete Bridge Components\n- I.L. Qadi, B.D. Prowell, R.E. Weyers, T. Dutta, H. Gouro, and N. Berke. Concrete Bridge Protection and Rehabilitation: Chemical and Physical Techniques, Corrosion Inhibitors and Polymers, Publication No. SHRP-S-666, Strategic Highway Research Program, National Research Council (NRC), Washington DC, 1993.\n- B.D. Prowell, R.E. Weyers, and I.L. Qadi. Concrete Bridge Protection and Rehabilitation: Chemical and Physical Techniques, Field Validation, Publication No. SHRP-S-658, SHRP, NRC, Washington DC, 1993.\n- Standard Method for Sampling and Testing for Chloride Ion in Concrete and Concrete Raw Materials, T-260, American Association of State and Highway Transportation Officials, Washington, DC, 1994.\n- Standard Test Methods for Half-Cell Potentials of Uncoated Reinforcing Steel in Concrete: C-876, In Annual Book of ASTM Standards - Construction; American Society for Testing and Materials, Philadelphia, PA. 1991.\nPrevious | Table", "domain": "chemistry", "round": 3} +{"url": "https://www.vet-ebooks.com/the-biochemistry-of-inorganic-polyphosphates-2nd-edition/", "date": "2023-06-01T08:36:07Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-23/segments/1685224647639.37/warc/CC-MAIN-20230601074606-20230601104606-00338.warc.gz", "language_score": 0.6555626392364502, "token_count": 1851, "dump": "CC-MAIN-2023-23", "global_id": "webtext-fineweb__CC-MAIN-2023-23__0__4420658", "lang": "en", "text": "The Biochemistry of Inorganic Polyphosphates 2nd Edition PDF Contents\nForeword to the First Edition.\n1 The Chemical Structures and Properties of Condensed Inorganic Phosphates.\n1.1 The Structures of Condensed Phosphates.\n1.1.3 Branched Inorganic Phosphates, or ‘Ultraphosphates’.\n1.2 Some Chemical Properties of Condensed Inorganic Polyphosphates.\n1.3 Physico-Chemical Properties of Condensed Inorganic Polyphosphates.\n2 Methods of Polyphosphate Assay in Biological Materials.\n2.1 Methods of Extraction from Biological Materials.\n2.2 Chromatographic Methods.\n2.3 Colorimetric and Fluorimetric Methods.\n2.4 Cytochemical Methods.\n2.5 X-Ray Energy Dispersive Analysis.\n2.6 31P Nuclear Magnetic Resonance Spectroscopy.\n2.7 Other Physical Methods.\n2.8 Gel Electrophoresis.\n2.9 Enzymatic Methods.\n3 The Occurrence of Polyphosphates in Living Organisms.\n4 The Forms in which Polyphosphates are Present in Cells.\n4.1 Polyphosphate–Cation Complexes.\n4.2 Polyphosphate–Ca2+–Polyhydroxybutyrate Complexes.\n4.3 Complexes of Polyphosphates with Nucleic Acids.\n4.4 Binding of Polyphosphates with Proteins.\n5 Localization of Polyphosphates in Cells of Prokaryotes and Eukaryotes.\n6 Enzymes of Polyphosphate Biosynthesis and Degradation.\n6.1 Enzymes of Polyphosphate Biosynthesis.\n6.1.1 Polyphosphate Kinase (Polyphosphate:ADP Phosphotransferase, EC 18.104.22.168).\n6.1.2 3-Phospho-D-Glyceroyl-Phosphate:Polyphosphate Phosphotransferase (EC 22.214.171.124).\n6.1.3 Dolichyl-Diphosphate:Polyphosphate Phosphotransferase (EC 126.96.36.199).\n6.2 Enzymes of Polyphosphate Degradation.\n6.2.1 Polyphosphate-Glucose Phosphotransferase (EC 188.8.131.52).\n6.2.2 NAD Kinase (ATP:NAD 2_-Phosphotransferase, EC 184.108.40.206).\n6.2.3 Exopolyphosphatase (Polyphosphate Phosphohydrolase, EC 220.127.116.11).\n6.2.4 Adenosine–Tetraphosphate Phosphohydrolase (EC 18.104.22.168).\n6.2.5 Triphosphatase (Tripolyphosphatase, EC 22.214.171.124).\n6.2.6 Endopolyphosphatase (Polyphosphate Depolymerase, EC 126.96.36.199).\n6.2.7 PolyP:AMP Phosphotransferase.\n7 The Functions of Polyphosphates and Polyphosphate-Dependent Enzymes.\n7.1 Phosphate Reserve.\n7.1.1 In Prokaryotes.\n7.1.2 In Eukaryotes.\n7.2 Energy Source.\n7.2.1 Polyphosphates in Bioenergetics of Prokaryotes.\n7.2.2 Polyphosphate in Bioenergetics of Eukaryotes.\n7.3 Cations Sequestration and Storage.\n7.3.1 In Prokaryotes.\n7.3.2 In Eukaryotes.\n7.4 Participation in Membrane Transport.\n7.5 Cell Envelope Formation and Function.\n7.5.1 Polyphosphates in the Cell Envelopes of Prokaryotes.\n7.5.2 Polyphosphates in the Cell Envelopes of Eukaryotes.\n7.6 Regulation of Enzyme Activities.\n7.7 Gene Activity Control, Development and Stress Response.\n7.7.1 In Prokaryotes.\n7.7.2 In Lower Eukaryotes.\n7.8 The Functions of Polyphosphates in Higher Eukaryotes.\n8 The Peculiarities of Polyphosphate Metabolism in Different Organisms.\n8.1 Escherichia coli.\n8.1.1 The Dynamics of Polyphosphates under Culture Growth.\n8.1.2 The Effects of Pi Limitation and Excess.\n8.1.3 The Effects of Mutations on Polyphosphate Levels and Polyphosphate-Metabolizing Enzyme Activities.\n8.1.4 The Effects of Nutrition Deficiency and Environmental Stress.\n8.2 Pseudomonas aeruginosa.\n8.4 Aerobacter aerogenes (Klebsiella aerogenes).\n8.6 Cyanobacteria (Blue–Green Algae) and other Photosynthetic Bacteria.\n8.7 Mycobacteria and Corynebacteria.\n8.10.1 Yeast Cells Possess Different Polyphosphate Fractions.\n8.10.2 The Dynamics of PolyP Fractions during the Cell Cycle.\n8.10.3 The Relationship between the Metabolism of Polyphosphates and other Compounds.\n8.10.4 Polyphosphate Fractions at Growth on a Pi-Sufficient Medium with Glucose.\n8.10.5 The Effects of Pi Limitation and Excess.\n8.10.6 The Effects of other Conditions on the Polyphosphate Content in Yeast Cells.\n8.10.7 The Effects of Inhibitors on the Polyphosphate Content in Yeast Cells.\n8.10.8 The Effects of Mutations on the Content and Chain Lengths of Polyphosphate in Yeast.\n8.11 Other Fungi (Mould and Mushrooms).\n8.12.1 Localization and Forms in Cells.\n8.12.2 The Dynamics of Polyphosphates in the Course of Growth.\n8.12.3 The Influence of Light and Darkness.\n8.12.4 The Effects of Pi Limitation and Excess.\n8.12.5 Changes in Polyphosphate Content under Stress Conditions.\n8.14 Higher Plants.\n9 Applied Aspects of Polyphosphate Biochemistry.\n9.1 Bioremediation of the Environment.\n9.1.1 Enhanced Biological Phosphate Removal.\n9.1.2 Removal of Heavy Metals from Waste.\n9.2 Polyphosphates and Polyphosphate-Metabolizing Enzymes in Assay and Synthesis.\n9.3 Polyphosphates in Medicine.\n9.3.1 Antiseptic and Antiviral Agents.\n9.3.2 Polyphosphate Kinase as a Promising Antimicrobial Target.\n9.3.3 Polyphosphates as New Biomaterials.\n9.3.4 Polyphosphates in Bone Therapy and Stomathology.\n9.4 Polyphosphates in Agriculture.\n9.5 Polyphosphates in the Food Industry.\n10 Inorganic Polyphosphates in Chemical and Biological Evolution.\n10.1 Abiogenic Synthesis of Polyphosphates and Pyrophosphate.\n10.2 Phosphorus Compounds in Chemical Evolution.\n10.3 Polyphosphates and Pyrophosphates: Fossil Biochemical Reactions and the Course of Bioenergetic Evolution.\n10.4 Changes in the Role of Polyphosphates in Organisms at Different Evolutionary Stages.\nIndex of Generic Names.", "domain": "chemistry", "round": 3} +{"url": "http://www.pimkinase.com/2016/04/overexpression-of-bcl-2-family-members-proteins-continues-to-be-found-in/", "date": "2024-04-25T08:42:53Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712297290384.96/warc/CC-MAIN-20240425063334-20240425093334-00604.warc.gz", "language_score": 0.9541391730308533, "token_count": 1167, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__159200315", "lang": "en", "text": "Overexpression of Bcl-2 family members proteins continues to be found in a number of aggressive individual carcinomas including pancreatic cancers suggesting that particular realtors targeting Bcl-2 Setrobuvir (ANA-598) family members proteins will be dear for pancreatic cancers therapy. cancers cell lines AsPC-1 BxPC-3 Colo-357 HPAC L3.6pl MIAPaCa and PANC-1 were found in this scholarly research. Principal antibodies for Bcl-2 Bcl-xL Mcl-1 Jagged-1 Notch-1 Hes-1 IL10RB cyclin A cyclin B cyclin D1 CDK2 CDK4 CDK6 FoxM1 p21 p57 and E2F-1 had been bought from Santa Cruz Biotechnology. All supplementary antibodies had been extracted from Pierce. γ-Secretase inhibitors L-685 458 and DAPT had been extracted from Calbiochem. TW-37 Style synthesis purification and chemical substance characterization of N-[(2-tert-butyl-benzenesulfonyl)-phenyl]-2 3 4 (TW-37) are defined at length by Wang and co-workers (11); within the inactive congener TW-37a all three hydroxyl groupings within the polyphenolic band have already been substituted using a methyl group producing a 100-fold lack of binding (11). Cell development inhibition tests by WST-1 assay The pancreatic cancers cells (5 × 103) had been seeded within a 96-well lifestyle dish. After 12 h cells had been treated with several concentrations of TW-37 for 24 48 and 72 h. After incubation the cell development inhibition studies had been performed by WST-1 assay based on the manufacturer’s guidelines. As well as the above assay we’ve also performed clonogenic assay for evaluating the consequences of treatment as proven below. Clonogenic assay To check the success of cells treated with TW-37 BxPC-3 and Colo-357 cells had been plated (50 0 0 per well) within a six-well dish and incubated right away at 37°C. After 72-h contact with several concentrations of TW-37 the cells had been put Setrobuvir Setrobuvir (ANA-598) (ANA-598) through a clonogenic assay as defined before (23). Stream cytometry and cell routine evaluation The TW-37-treated cells as indicated previously were trypsinized washed and collected twice with PBS. Cell pellets had been set in 70% ethanol as well as the percentage of cells in various phases from the cell routine was examined as defined before (24). Histone/DNA ELISA for recognition of apoptosis The Cell Loss of life Detection ELISA Package was useful for evaluating apoptosis based on the manufacturer’s process. Quickly after TW-37 treatment the cells had been lysed as well as the cell lysates had been overlaid and incubated in microtiter dish modules covered with anti-histone antibody for recognition of apoptosis as defined previously (10). Annexin V assay Characterization of apoptosis was completed after propidium iodide and Annexin V-FITC staining with apoptosis recognition kit (Pharmingen) accompanied by stream cytometric evaluation after 48 h of 500 nmol/L TW-37 treatment of BxPC-3 and Colo-357 based on the manufacturer’s guidelines. Hoechst staining and terminal deoxynucleotidyltransferase-mediated nick end labeling assay for recognition of apoptosis Cells had been treated with TW-37 for 72 h as defined above. After treatment cells had been washed with frosty PBS and set in ethanol for 1 h. The cells had been after that stained with 5 μg/mL Hoechst for 30 min and visualized under a fluorescence microscope. Shiny condensed punctuate or granular nuclei had been considered apoptotic. Furthermore terminal deoxynucleotidyltransferase-mediated nick end labeling (TUNEL) was assayed using a industrial apoptosis detection package (Promega Corp.). Traditional western blot evaluation Cells had been lysed in lysis buffer by incubating for 20 min at 4°C. The proteins concentration was driven utilizing the Bio-Rad assay program (Bio-Rad). Total protein had been fractionated using SDS-PAGE and moved onto a nitrocellulose membrane for Traditional western blotting as defined previously Setrobuvir (ANA-598) (10). Real-time invert transcription-PCR evaluation for gene appearance studies The full total RNA from treated cells was isolated by Trizol (Invitrogen) and purified by RNeasy Mini Package and RNase-free DNase Established (Qiagen) based on the manufacturer’s protocols. The primers found in the PCR response for Notch-1 Jagged-1 Hes-1 p21 p27 p57 E2F-1 Survivin Cdc25A FoxM1 and β-actin had been defined before (19 24 Real-time PCR amplifications had been performed as defined previously (24). Immunofluorescence staining The cells had been plated on coverslips in each well of the eight-well chamber for 24 h. After treatment of TW-37 for 72 h cells had been then set with paraformaldehyde for 15 min rinsed with PBS and incubated with 5% goat serum for 30 min. The cells were incubated with anti-Notch-1 and anti-Jagged-1 antibody for 2 h respectively then..", "domain": "chemistry", "round": 3} +{"url": "https://www.lsbio.com/antibodies/drd2-antibody-dopamine-receptor-d2-antibody-3rd-cytoplasmic-domain-elisa-wb-western-ls-c22926/23508", "date": "2022-08-10T08:14:01Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571150.88/warc/CC-MAIN-20220810070501-20220810100501-00041.warc.gz", "language_score": 0.7639336585998535, "token_count": 426, "dump": "CC-MAIN-2022-33", "global_id": "webtext-fineweb__CC-MAIN-2022-33__0__202231448", "lang": "en", "text": "Human DRD2 / Dopamine Receptor D2\nDRD2 | D2R | D(2) dopamine receptor | D2DR\n(tested or 100% immunogen sequence identity)\nA 28 AA synthetic peptide sequence from the human D2 R, within the cytoplasmic loop # 3 (KLH). The 28 AA sequence is shared by both the long and short form.\n3rd Cytoplasmic Domain\nRecognizes human D2R. No significant sequence homology is seen with other dopamine receptors (D1 and D3-D5). Species sequence homology: Bovine, canine-100%; xenopus-50%.\n- Western blot (1:1000 - 1:5000)\n- ELISA (1:10000 - 1:50000)\nSuitable for use in ELISA and Western Blot. Western Blot: 1:1000-1:5000 (ECL) The predicted size of D2 form is approx. 50kD. However, additional bands at approx. 100kD, 68kD, and 50kD, and others are typically seen in various tissues. Approx. 100-400 ug membrane protein/lane should be loaded to visualize various bands. ELISA: 1:10000-1:50000. Use 1 ug/ml to coat ELISA plates.\nSupplied as liquid in PBS, 0.05% sodium azide, 40% glycerol.\nShort term: store at 4°C. Long term: store at -20°C. Avoid freeze-thaw cycles.\nFor research use only. Intended for use by laboratory professionals.\nThis antibody carries the LSBio 100% Guarantee.\nAbout DRD2 / Dopamine Receptor D2", "domain": "chemistry", "round": 3} +{"url": "https://ijp.uobaghdad.edu.iq/index.php/physics/article/view/1093", "date": "2023-06-02T07:26:22Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-23/segments/1685224648465.70/warc/CC-MAIN-20230602072202-20230602102202-00496.warc.gz", "language_score": 0.6939887404441833, "token_count": 1870, "dump": "CC-MAIN-2023-23", "global_id": "webtext-fineweb__CC-MAIN-2023-23__0__83217337", "lang": "en", "text": "FTIR and Electrical Behavior of Blend Electrolytes Based on (PVA/PVP)\nMain Article Content\nPolymer electrolytes were prepared using the solution cast technology. Under some conditions, the electrolyte content of polymers was analyzed in constant percent of PVA/PVP (50:50), ethylene carbonate (EC), and propylene carbonate (PC) (1:1) with different proportions of potassium iodide (KI) (10, 20, 30, 40, 50 wt%) and iodine (I2) = 10 wt% of salt. Fourier Transmission Infrared (FTIR) studies confirmed the complex formation of polymer blends. Electrical conductivity was calculated with an impedance analyzer in the frequency range 50 Hz–1MHz and in the temperature range 293–343 K. The highest electrical conductivity value of 5.3 × 10-3 (S/cm) was observed for electrolytes with 50 wt% KI concentration at room temperature. The magnitude of electrical conductivity was increased with the increase in the salt concentration and temperature. The blend electrolytes have a high dielectric constant at lower frequencies which may be attributed to the dipoles providing sufficient time to get aligned with the electric field, resulting in higher polarization. The reduction of activation energy (Ea) suggests that faster-conducting electrolyte ions want less energy to move.\nThis work is licensed under a Creative Commons Attribution 4.0 International License.\nAuthors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution (CC-BY) 4.0 License that allows others to share the work with an acknowledgement of the work’s authorship and initial publication in this journal.\nN. M. Sadiq, S. B. Aziz, and M. F. Z. Kadir, Gels 8, 153 (2022).\nH. Yang, Y. Liu, L. Kong, L. Kang, and F. Ran, J. Pow. Sources 426, 47 (2019).\nM. S. Su’ait, M. Y. A. Rahman, and A. Ahmad, Solar Ener. 115, 452 (2015).\nC. Tao, M.-H. Gao, B.-H. Yin, B. Li, Y.-P. Huang, G. Xu, and J.-J. Bao, Electrochi. Acta 257, 31 (2017).\nS. N. a. M. Johari, N. A. Tajuddin, H. Hanibah, and S. K. Deraman, Int. J. Electrochem. Sci. 16, 2 (2021).\nH. G. Rauf, J. M. Hadi, S. B. Aziz, R. T. Abdulwahid, and M. S. Mustafa, Int. J. Electrochem. Sci. 17, 2 (2022).\nY. Zhao, L. Wang, Y. Zhou, Z. Liang, N. Tavajohi, B. Li, and T. Li, Advan. Sci. 8, 2003675 (2021).\nJ. C. Barbosa, J. P. Dias, S. Lanceros-Méndez, and C. M. Costa, Membranes 8, 45 (2018).\nM. Shukur, R. Ithnin, H. Illias, and M. Kadir, Optic. Mater. 35, 1834 (2013).\nY. Liu, B. Xu, W. Zhang, L. Li, Y. Lin, and C. Nan, Small 16, 1902813 (2020).\nJ. Wang, S. Li, Q. Zhao, C. Song, and Z. Xue, Advan. Func. Mater. 31, 2008208 (2021).\nS. Jha, V. Bhavsar, K. Sooraj, M. Ranjan, and D. Tripathi, J. Advan. Dielec. 11, 2150020 (2021).\nD. Akram and N. Hameed, J. Appl. Sci. Nanotech. 2, 38 (2022).\nS. I. Wani and A. S. Ganie, Inorg. Chem. Commun. 128, 108567 (2021).\nE. A. Swady and M. K. Jawad, Iraqi J. Phys. 19, 15 (2021).\nJ. O. Dennis, A. A. Adam, M. Ali, H. Soleimani, M. F. B. A. Shukur, K. Ibnaouf, O. Aldaghri, M. Eisa, M. Ibrahem, and A. Bashir Abdulkadir, Membranes 12, 706 (2022).\nK. Deshmukh, M. B. Ahamed, K. K. Sadasivuni, D. Ponnamma, M. a. A. Almaadeed, R. R. Deshmukh, S. K. Pasha, A. R. Polu, and K. Chidambaram, J. Appl. Poly. Sci. 134, 44427 (2017).\nN. Badi, A. M. Theodore, S. A. Alghamdi, H. A. Al-Aoh, A. Lakhouit, A. S. Roy, A. S. Alatawi, and A. Ignatiev, Polymers 14, 3837 (2022).\nM. A. Jothi, D. Vanitha, N. Nallamuthu, A. Manikandan, and S. A. Bahadur, Phys. B: Conden. Matt. 580, 411940 (2020).\nH. Alfannakh, Advan. Mater. Sci. Eng. 2022, 1 (2022).\nD. Vanitha, S. A. Bahadur, N. Nallamuthu, A. Shunmuganarayanan, and A. Manikandan, J. Nanosci. Nanotech. 18, 1723 (2018).\nM. Kadhim Jawad, Iraqi J. Phys. 17, 76 (2019).\nS. Nippani, P. Kuchhal, G. Anand, and V. K. Kambila, J. Eng. Sci. Tech. 11, 1595 (2016).\nM. M. Nofal, J. M. Hadi, S. B. Aziz, M. A. Brza, A. S. Asnawi, E. M. Dannoun, A. M. Abdullah, and M. F. Kadir, Materials 14, 4859 (2021).\nY. Horowitz, M. Lifshitz, A. Greenbaum, Y. Feldman, S. Greenbaum, A. P. Sokolov, and D. Golodnitsky, J. Electrochem. Soci. 167, 160514 (2020).\nD. Padalia, U. Johri, and M. Zaidi, Phys. B: Conden. Matt. 407, 838 (2012).\nR. Das and R. Choudhary, J. Advan. Cer. 8, 174 (2019).\nC. Behera and A. Pattanaik, J. Mater. Sci.: Mater. Electro. 30, 5470 (2019).\nM. S. Grewal, K. Kisu, S.-I. Orimo, and H. Yabu, Iscience 25, 104910 (2022).\nA. B. J. Kharrat, N. Moutia, K. Khirouni, and W. Boujelben, Mater. Res. Bull. 105, 75 (2018).\nH. Yin, C. Han, Q. Liu, F. Wu, F. Zhang, and Y. Tang, Small 17, 2006627 (2021).\nS. Salehan, B. Nadirah, M. Saheed, W. Yahya, and M. Shukur, J. Poly. Res. 28, 1 (2021).\nO. Nordness and J. F. Brennecke, Chem. Rev. 120, 12873 (2020).\nT. Otitoju, P. Okoye, G. Chen, Y. Li, M. Okoye, and S. Li, J. Indus. Eng. Chem. 85, 34 (2020).\nV. Shanthala, S. Devi, and M. Murugendrappa, IOSR: J. App. Phys. 8, 83 (2016).", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/dmrtb1-antibody-ab224158.html", "date": "2020-10-26T05:10:10Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-45/segments/1603107890273.42/warc/CC-MAIN-20201026031408-20201026061408-00205.warc.gz", "language_score": 0.6901445388793945, "token_count": 298, "dump": "CC-MAIN-2020-45", "global_id": "webtext-fineweb__CC-MAIN-2020-45__0__153603490", "lang": "en", "text": "Key features and details\n- Rabbit polyclonal to DMRTB1\n- Suitable for: IHC-P\n- Reacts with: Human\n- Isotype: IgG\nStorage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.\nStorage bufferpH: 7.20\nPreservative: 0.02% Sodium azide\nConstituents: 40% Glycerol (glycerin, glycerine), PBS\nConcentration information loading...\nPurityImmunogen affinity purified\nOur Abpromise guarantee covers the use of ab224158 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\n|IHC-P||1/200 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.|\nSequence similaritiesBelongs to the DMRT family.\nContains 1 DM DNA-binding domain.\n- Information by UniProt\n- DMRT B 1 antibody\n- DMRT like family B with proline rich C terminal 1 antibody\n- DMRTB_HUMAN antibody\nab224158 has not yet been referenced specifically in any publications.", "domain": "chemistry", "round": 3} +{"url": "https://investigadores.anid.cl/es/public_search/work?id=659044", "date": "2024-04-18T13:18:56Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712296817206.54/warc/CC-MAIN-20240418124808-20240418154808-00421.warc.gz", "language_score": 0.8166851997375488, "token_count": 470, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__166406284", "lang": "en", "text": "Statistical Optimisation of Diesel Biodegradation at Low Temperatures by an Antarctic Marine Bacterial Consortium Isolated from Non-Contaminated Seawater\nHydrocarbon pollution is widespread around the globe and, even in the remoteness of Antarctica, the impacts of hydrocarbons from anthropogenic sources are still apparent. Antarctica's chronically cold temperatures and other extreme environmental conditions reduce the rates of biological processes, including the biodegradation of pollutants. However, the native Antarctic microbial diversity provides a reservoir of cold-adapted microorganisms, some of which have the potential for biodegradation. This study evaluated the diesel hydrocarbon-degrading ability of a psychrotolerant marine bacterial consortium obtained from the coast of the north-west Antarctic Peninsula. The consortium's growth conditions were optimised using one-factor-at-a-time (OFAT) and statistical response surface methodology (RSM), which identified optimal growth conditions of pH 8.0, 10 degrees C, 25 ppt NaCl and 1.5 g/L NH4NO3. The predicted model was highly significant and confirmed that the parameters' salinity, temperature, nitrogen concentration and initial diesel concentration significantly influenced diesel biodegradation. Using the optimised values generated by RSM, a mass reduction of 12.23 mg/mL from the initial 30.518 mg/mL (4% (w/v)) concentration of diesel was achieved within a 6 d incubation period. This study provides further evidence for the presence of native hydrocarbon-degrading bacteria in non-contaminated Antarctic seawater.\n|Título según WOS:\n|Statistical Optimisation of Diesel Biodegradation at Low Temperatures by an Antarctic Marine Bacterial Consortium Isolated from Non-Contaminated Seawater\n|Título de la Revista:\n|Fecha de publicación:", "domain": "chemistry", "round": 3} +{"url": "https://wallinside.com/post-55030745-1-way-in-which-to-conquer-this-dilemma-is-to-try-and-conformationally-restrain.html", "date": "2018-04-24T18:27:21Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-17/segments/1524125947033.92/warc/CC-MAIN-20180424174351-20180424194351-00050.warc.gz", "language_score": 0.9310492277145386, "token_count": 817, "dump": "CC-MAIN-2018-17", "global_id": "webtext-fineweb__CC-MAIN-2018-17__0__148835868", "lang": "en", "text": "1 way in which to conquer this dilemma is to try and conformationally restrain\nIn the people with Wernicke Korsakoff We have beforehand synthesised inside our laboratories mono alkyl chain uracil acetamides with the amide bond insertion into the alkyl linker chain at the placement syndrome characterised by serious TD, tangles have been identified in their brains, specifically in persistent alcoholics. In all, glucose metabolic rate impairment could raise Ab aggregation and tau hyperphosphorylation via different mechanisms. Even so, multiple pathogenic casces induced by impaired glucose metabolism could be the basic impetus to type phenotype. These several pathogenic casces consist of oxidative pressure and mitochondria dysfunction, AGEs production, inflammatory components, excitotoxicity, autophagy impairment, and GSK-three activation and so on. Even though human brain only occupies two of the physique by excess weight, mind metabolic rate demands about 20 of the oxygen equipped by the full respiratory program. As a result, it is an organ with significant vitality output and usage, which would make it much more prone to mitochondria abnormality and oxidative tension than any other organs. Existing study, in simple fact, indicates that equally mitochondria dysfunction and oxidative anxiety enjoy an critical position in the pathogenesis. Oxidative strain is a outcome of misbalance of oxidative system and antioxidant system of the cells. Some investigators proposed a two-strike speculation to clarify the function of oxidative strain in pathology. Also, oxidative markers, typically like eight- hydroxyguanosine seems to precede all the typical hallmarks of , these as NFTs and Ab plaques. Especially, scientific studies showed that appears deces prior to Ab aggregation. The Tg2576 transgenic mice exhibited oxidative injury prior to Ab aggregation. In , iron deposition has been demonstrated to display the affiliation with oxidative strain, which leads to elevated protein and DNA oxidation, and inactivation of the human mind muscarinic cholinergic receptor necessary for memory. In addition, iron chelators, this kind of as intranasal desferrioxamine, also have been shown to display valuable consequences in sufferers or transgenic designs. As a result, iron deposition could perform a important purpose in the pathogenesis of . In this scenario, oxidative anxiety is supposed to be an authentic contributor to pathogenesis. Glucose-six-phosphate dehydrogenase is the amount-limiting enzyme of the phosphate pentose shunt, which performs an essential position in the redox balance of cells. It participated in homeostatic redox handle by delivering lowering equivalents to glutathione. Russell have identified an up-regulation of G6PDH with each other with enhanced sulfhydryls in , which implies that reductive compensation performs a important role in fighting oxidative tension in . Hence, by taking away the ROS produced by neuronal oxidative stress, neurons might give on their own a handy approach for self-security in mind. Carbonyl tension marked by AGEs could also induce cell dysfunction, which contributes to pathology. AGEs have been demonstrated to be a prevalent pathological pathway ensuing in CNS ailment development. As opposed with younger folks and non-demented controls, AGEs have been identified to We have earlier synthesised inside our laboratories mono alkyl chain uracil acetamides with the amide bond insertion into the alkyl linker chain at the place increase in neurons of growing older and , and even worse with the development of . Apparently, intracellular AGEs accumulation has been noticed in of pyramidal neurons of clients with familial , which indicates that AGEs may possibly contribute to greater neuronal dysfunction and vulnerability. Impaired glucose rate of metabolism induces mitochondria dysfunction and oxidative pressure, which may le to the activation of apoptotic pathway mediated by mitochondria. Apoptosis, or programmed mobile demise, performs important roles in mind progress, as effectively as neurodegenerative illness, which include .", "domain": "chemistry", "round": 3} +{"url": "https://m.scirp.org/papers/27337", "date": "2021-01-22T19:43:51Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-04/segments/1610703531335.42/warc/CC-MAIN-20210122175527-20210122205527-00093.warc.gz", "language_score": 0.7318004965782166, "token_count": 1241, "dump": "CC-MAIN-2021-04", "global_id": "webtext-fineweb__CC-MAIN-2021-04__0__97759419", "lang": "en", "text": "O. Strebel, W. H. M. Dunynisveld and J. Bottcher, “Nitrate pollution of groundwater in western Europe,” Agriculture Ecosystem and Environment, Vol. 26, No. 3-4, 1989, pp. 189-214. doi:10.1016/0167-8809(89)90013-3\n J. F. Power and J. S. Schepers, “Nitrate Contamination of Groundwater in North America,” Agriculture Ecosystem and Environment, Vol. 26, No. 3-4, 1989, pp. 165-187. doi:10.1016/0167-8809(89)90012-1\n J. L. Costa, H. Massone, D. Marrtinez and E. E. Soero, C. M. Vidal, F. Bedmar, “Nitrate Contamination of a Rural Aquifer and Accumulation in the Unsaturated Zone,” Agricultural Water Management, Vol. 57, No. 1, 2002, pp. 33-47. doi:10.1016/S0378-3774(02)00036-7\n K. Chaney, “Effect of Nitrogen Fertilizer Rate on Soil Nitrate Content after Harvesting Winter Wheat,” The Jour nal of Agricultural Science, Vol. 114, No. 2, 1990, pp. 171-176. doi:10.1017/S0021859600072166\n W. T. Cai, F. Chen, H. L. Zhang, J. Lei and X. Y. Wen, “Effects of Different Nitrogen Fertilization Levels on Yield of Cucumber, the Soil Nitrate-N Accumulation and the Soil Solution Nitrate-N Concentrations,” Acta Agriculturae Boreali-Sinica, Vol. 24, No. 3, 2009, pp. 189 193.\n Z. P. Yang, M. C. Chen, Q. Zhang and J. J. Zhang, “Effects of Different Fertilizer Measurement on Nutrient Utilization in Cucumber and Nitrate Leaching Loss from Soil in Greenhouse,” Journal of Soil and Water Conservation, Vol. 21, No. 2, 2007, pp. 57-60.\n H. B. Liu, Z. H. Li, Y. G. Zhang, W. L. Zhang and B. Lin, “Nitrate Contamination of Groundwater and Its Affecting Factors in Rural Areas of Beijing Plain,” Accta Pe Dologica Sinica, Vol. 43, No. 3, 2006, pp. 405-413.\n S. P. Chen, X. Z. Wang, X. Z. Qian and J. Li, “Comparation and Relative Analyses on the Digesting Time and Results of Catalyst Mixtures of Plant Total Nitrogen in Kjeldahl Mothed,” Acta Agriculturae Boreali-Sinica, Vol. 21, 2006, pp. 19-22.\n X. M. Yuan, Y. A. Tong, X. Y. Yang, X. L. Li and F. S. Zhang, “Effect of Phosphate Application on Soil Nitrate Nitrogen Accumulation,” Plant Nutrition and Fertilizer Scieence, Vol. 6, No. 4, 2000, pp. 397-403.\n C. Y. Tian, Z. A. Lin, Y. B. Zuo, W. Y. Sun, S. G. Che, M. F. Cheng and B. Q. Zhao, “Review on Several Con cepts on Fertilizer Nitrogen Recovery Rate and Its Calculation,” Chinese Journal of Soil science, Vol. 42, No. 6, 2011, pp. 1531-1536.\n X. J. Zhang, G. F. Zhao, W. P. Zhu, X. Q. Chen, L. M. Wang, L. S. Wu and C. X. Hu, “Nitrogen Leaching from Vegetable Soil and Control Measures: A Review,” Ecology and Environment, Vol. 13, No. 1, 2004, pp. 105-108.\n Y. Wei, L. P. Sun, S. Z. Wang, Y. Q. Wang, Z. X. Zhang, Q. Y. Chen, H. Z. Ren and L. H. Gao, “Effects of Diffe rent Irrigation Methods on Water Distribution and Nitrate Nitrogen Transport of Cucumber in Greenhouse,” Transactions of the CSAE, Vol. 26, No. 8, 2010, pp. 67-72.\n P. Q. Guo, X. H. Li, K. A. Wang and N. Yang, “Effects of Different Levels N Application on the Nitrate Accumulation in Cucumber and Soil in Solar Greenhouse,” Acta Agriculturae Boreali-Sinica, Vol. 24, No. 1, 2009, pp. 185-188.\n H. B. Liu, Z. H. Li, W. L. Zhang and B. Lin, “Study on N Use Efficiency of Chinese Cabbage and Nitrate Leaching under Open Field Cultivation,” Plant Nutrition and Fertilizer Science, Vol. 10, No. 3, 2004, pp. 286-291.\n L.Wang, F. M. Zhang and X. J. Wei, “Effects of Different Nitrogen Fertilization Levels on Quality and Yield of Cu cumber Cultivated in Solar Greenhouse,” Transactions of the CSAE, Vol. 23, No. 12, 2007, pp. 225-229.", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/hmgn2-antibody-ab199679.html", "date": "2020-07-16T00:50:51Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-29/segments/1593657176116.96/warc/CC-MAIN-20200715230447-20200716020447-00100.warc.gz", "language_score": 0.72071772813797, "token_count": 701, "dump": "CC-MAIN-2020-29", "global_id": "webtext-fineweb__CC-MAIN-2020-29__0__32521223", "lang": "en", "text": "Key features and details\n- Rabbit polyclonal to HMGN2\n- Suitable for: IHC-P, WB, ICC/IF\n- Reacts with: Mouse, Rat, Human\n- Isotype: IgG\nProduct nameAnti-HMGN2 antibody\nSee all HMGN2 primary antibodies\nDescriptionRabbit polyclonal to HMGN2\nTested applicationsSuitable for: IHC-P, WB, ICC/IFmore details\nSpecies reactivityReacts with: Mouse, Rat, Human\nSynthetic peptide within Human HMGN2 aa 2-35. The exact sequence is proprietary.\nDatabase link: P05204\n- SH SY5Y cell lysate; HeLa cells and Human brain tissue\nStorage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.\nStorage bufferpH: 7.40\nPreservative: 0.02% Sodium azide\nConstituents: 49% PBS, 50% Glycerol, 0.88% Sodium chloride\nPBS is without Mg2+ and Ca2+.\nConcentration information loading...\nPurityProtein A purified\nOur Abpromise guarantee covers the use of ab199679 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\n|IHC-P||1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.|\n|WB||1/1000. Predicted molecular weight: 9 kDa.|\nFunctionBinds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in an unique chromatin conformation.\nSequence similaritiesBelongs to the HMGN family.\nmodificationsPhosphorylation favors cytoplasmic localization.\nCellular localizationNucleus. Cytoplasm. Cytoplasmic enrichment upon phosphorylation.\n- Information by UniProt\n- High mobility group (nonhistone chromosomal) protein 17 antibody\n- high mobility group nucleosomal binding domain 2 antibody\n- High mobility group nucleosome-binding domain-containing protein 2 antibody\nImmunofluorescent analysis of HeLa cells labeling HMGN2 using ab199679 at 1/100 dilution.\nAnti-HMGN2 antibody (ab199679) at 1/1000 dilution + SH SY5Y cell lysate at 35 µg\nGoat anti-rabbit IgG H&L(HRP) at 1/5000 dilution\nPredicted band size: 9 kDa\nImmunohistochemical analysis of Human brain tissue labeling HMGN2 using ab199679 at 1/50 dilution (left) and negative control (right).\nab199679 has been referenced in 1 publication.\n- Li Q et al. Increased expression of high-mobility group nucleosomal-binding domain 2 protein in various tumor cell lines. Oncol Lett 15:4517-4522 (2018). PubMed: 29541221", "domain": "chemistry", "round": 3} +{"url": "https://labnodes.vanderbilt.edu/publication/view/pmid/16060859", "date": "2021-01-24T20:12:38Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-04/segments/1610703550617.50/warc/CC-MAIN-20210124173052-20210124203052-00407.warc.gz", "language_score": 0.9098219275474548, "token_count": 384, "dump": "CC-MAIN-2021-04", "global_id": "webtext-fineweb__CC-MAIN-2021-04__0__33540898", "lang": "en", "text": "The mechanisms of the mitochondrial toxicity of AZT (azidothymidine; zidovudine) are not clear. The two main contenders are the incorporation of phosphorylated AZT into the mtDNA (mitochondrial DNA) and the competitive inhibition of natural deoxynucleotide metabolism. We have built a computational model of AZT metabolism in mitochondria in order to better understand these toxicity mechanisms. The model includes the transport of non-phosphorylated and phosphorylated forms of AZT into mitochondria, phosphorylation, and incorporation into mtDNA. The model also includes the mitochondrial metabolism of the natural deoxynucleotides. We define three simulated cell types, i.e. rapidly dividing, slowly dividing and postmitotic cells. Our standard simulation indicates that incorporation of AZT into mtDNA is highest in rapidly dividing cells because of the higher mitochondrial AZTTP (3'-azidothymidine-5'-triphosphate)/dTTP ratio in this cell type. However, under these standard conditions the rate of incorporation into mtDNA is too low to be a major cause of toxicity. These simulations relied on the assumption that phosphorylated AZT is transported with the same kinetics as phosphorylated thymidine. In simulations with mitochondria set to have a limited ability to transport phosphorylated AZT, AZTTP accumulates to toxic levels in the mitochondria of postmitotic cells, while low levels are maintained in mitochondria from rapidly dividing cells. This result is more consistent with the tissue toxicities observed in patients. Our model also predicts that inhibition by AZT of mitochondrial deoxycytidine phosphorylation by thymidine kinase 2 may contribute to the mitochondrial toxicity, since in simulations using a typical peak plasma AZT level the mtDNA replication rate is decreased by 30% in postmitotic cell simulations.", "domain": "chemistry", "round": 3} +{"url": "http://gojapan.seamolec.org/index.php/read/basic-gas-chromatography", "date": "2019-02-22T13:29:17Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-09/segments/1550247517815.83/warc/CC-MAIN-20190222114817-20190222140817-00470.warc.gz", "language_score": 0.6526622176170349, "token_count": 1098, "dump": "CC-MAIN-2019-09", "global_id": "webtext-fineweb__CC-MAIN-2019-09__0__221833617", "lang": "en", "text": "Basic gas chromatography by Harold M. McNair, James M. Miller\nBy Harold M. McNair, James M. Miller\nRead Online or Download Basic gas chromatography PDF\nBest analytic books\nThis is often the 1st ebook to add interfacial nanochemistry of liquid/liquid interfaces, that's a brand new boundary box among analytical chemistry, colloid and floor chemistry, electrochemistry, laser spectroscopy, separation engineering, and interfacial natural synthesis. The liquid/liquid interface is a truly basic topic of curiosity either to natural and commercial chemists, in particular these engaged in examine on solvent extraction of steel ion and natural compounds, interfacial synthesis, and micro-scale research.\nThis is often the 1st ebook to target the most recent advancements in hyphenated suggestions utilizing supercritical fluids. some great benefits of SFC in hyphenation with quite a few detection modes, corresponding to FTIR, MS, MPD and ICP and others are in actual fact featured during the e-book. certain cognizance is paid to coupling of SFE with GC or SFC.\nAs protein technological know-how maintains to develop into an more and more very important point of educational and advertisement sciences and know-how, the necessity has arisen for a prepared resource of laboratory protocols for the research and review of those organic polymers. tools for Protein research provides the tools so much correct to the generalist bench scientist operating with proteins.\nDie Reihe Chemie Basiswissen stellt den gesamten Wissensstoff für das Bachelorstudium Chemie dar. Studenten mit Chemie im Nebenfach und Studierende des höheren Lehramtes dient sie zur Examensvorbereitung. Der Band II, Organische Chemie, präsentiert den Stoff dieses Gebietes in kurzer und übersichtlicher shape.\n- Prompt Gamma Neutron Activation Analysis\n- Characterization of Nanostructures\n- Analytic Theory of Continued Fractions II: Proceedings of a Seminar-Workshop held in Pitlochry and Aviemore, Scotland June 13–29, 1985\n- Classification of Algebraic and Analytic Manifolds: Katata Symposium Proceedings 1982\n- Handbook of Acid-Base Indicators\n- Automated Reasoning with Analytic Tableaux and Related Methods : International Conference, TABLEAUX 2003, Rome, Italy, September 2003. Proceedings\nExtra info for Basic gas chromatography\nE. Amoore and E. Hautala, Journal of Applied Toxicology, 1983, 3, 6, 272. 31. T. Morikawa, Journal of Combustion Toxicology, 1978, 5, 315. 32. A. Purser, P. R. Berrill, Archives of Environmental Health, 1984, 38, 308. 33. K. M. J. 1. 34. M. F. 700. 35. M. E. W. A. 419. 36. A. Sainrat and Y. 419. 37. M. A. Purser, Fire and Materials, 1993, 17, 7. 38. C. J. M. Birky, M. Paabo, A. Stolte and D. Malek, Further Development of a Test Method for the Assessment of the Acute Inhalation Toxicity of Combustion Products, NBSIR 82-2532, National Bureau of Standards, Gaithersburg, MD, USA, 1982.\nL. 342. 42 Generation of Combustion Products from Polymeric Materials (Smoke Toxicity) 29. M. Le Bras, D. Price and S. , J. 189. 30. E. Amoore and E. Hautala, Journal of Applied Toxicology, 1983, 3, 6, 272. 31. T. Morikawa, Journal of Combustion Toxicology, 1978, 5, 315. 32. A. Purser, P. R. Berrill, Archives of Environmental Health, 1984, 38, 308. 33. K. M. J. 1. 34. M. F. 700. 35. M. E. W. A. 419. 36. A. Sainrat and Y. 419. 37. M. A. Purser, Fire and Materials, 1993, 17, 7. 38. C. J. M. Birky, M.\n40. J. 71. 41. D. D. Woolley, Journal of Fire Sciences, 1983, 1, 118. 43 Practical Guide to Smoke and Combustion Products from Burning Polymers 42. M. Hirschler, Journal of Fire Sciences, 1987, 5, 289. 43. W. F. Reinhard, Modern Plastics, 1973, 2, 94. 44. D. R. Horrocks and D. 69. 45. , B. Sunsdtrom, European Commission Measurement and Testing Report, EUR 16477 EN, Interscience Communication, London, UK, 1995. 46. V. H. G. C. T. D. Peacock, M. Paabo, W. F. M. 749, National Bureau of Standards, Gaithersburg, MD, USA, 1988.", "domain": "chemistry", "round": 3} +{"url": "https://www.legacydentistry.com/treatments/holistic-dentistry/amalgam-fillings/", "date": "2019-02-21T21:45:04Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-09/segments/1550247511174.69/warc/CC-MAIN-20190221213219-20190221235219-00617.warc.gz", "language_score": 0.9488025307655334, "token_count": 321, "dump": "CC-MAIN-2019-09", "global_id": "webtext-fineweb__CC-MAIN-2019-09__0__234994370", "lang": "en", "text": "We do not use amalgam (“mercury”) fillings at Legacy Dentistry. However, it is important to know the risks and benefits of this material, so that you can make an informed decision when seeking dental care.\nDental Amalgam is a commonly used dental filling that has been used for over 150 years. It is a mixture of mercury with at least one other metal. Amalgam has many advantages over other restorative material, such as low cost, strength, durability, and bacteriostatic effects.\nAmalgam is used in dentistry for a number of reasons. It is relatively easy to use and manipulate during placement; it remains soft for a short time so it can be packed to fill any irregular volume, and then forms a hard compound. Amalgam possesses greater longevity than other direct restorative materials, such as composite. On average, most amalgam restorations serve for 10 to 12 years, whereas resin-based composites serve for about half that time. However, with recent improvements in composite material science and a better understanding of the technique-sensitivity of placement, it should be noted that this difference is decreasing.\nThe American Dental Association Council on Scientific Affairs has concluded that both amalgam and composite materials are considered safe and effective for tooth restoration.\nDespite the ADA’s continued support of amalgam fillings, and the material’s clear clinical benefits, there are enough environmental and safety concerns that we feel it is important we exclude amalgam fillings as a treatment option in our practice.", "domain": "chemistry", "round": 3} +{"url": "https://wu-jing.org/kebene-plus-and-well-being-returns/", "date": "2021-06-19T16:05:05Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-25/segments/1623487648373.45/warc/CC-MAIN-20210619142022-20210619172022-00327.warc.gz", "language_score": 0.8363132476806641, "token_count": 267, "dump": "CC-MAIN-2021-25", "global_id": "webtext-fineweb__CC-MAIN-2021-25__0__24657965", "lang": "en", "text": "WHY KEBENE PLUS?\n- The first combination of simethicone and activated carbon available in Romania\n- Double mechanism of action\n- Kebene Plus ensures superior efficacy by combining activated carbon with simethicone in a double-layer tablet, through multi-layer technology.\n- QUICK ACTION IN JUST 15 MINUTES !\n- NO ADVERSE REACTIONS observed in the medium or long term!\nHOW DOES IT ACT?\n- Kebene Plus activated carbon is a good absorbent and retains gases on its surface, favoring their elimination.\n- Simethicone in Kebene does not interfere with gastric secretion or absorption of nutrients, is not metabolized, leaves the body unchanged, so it has no known side effects.\nKEBENE PLUS IS RECOMMENDED IN:\n- Treatment of symptoms due to gastrointestinal bloating\n- Reducing pain and cramps due to the accumulation of intestinal gas\n- Prevention of flatulence and belching\nHOW IS KEBENE PLUS ADMINISTRATED?\n- The recommended dose is 4 tablets a day, preferably 2 tablets after the main meal. Swallow the tablets whole with a glass of water\nAccording to Cegedim data.\nProspect Kebene Plus\nData from the product file.", "domain": "chemistry", "round": 3} +{"url": "https://oncirculation.wordpress.com/the-basics/tools-of-the-trade/accelerator-mass-spectrometry-ams/", "date": "2022-10-04T23:06:54Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-40/segments/1664030337529.69/warc/CC-MAIN-20221004215917-20221005005917-00135.warc.gz", "language_score": 0.8795264959335327, "token_count": 368, "dump": "CC-MAIN-2022-40", "global_id": "webtext-fineweb__CC-MAIN-2022-40__0__232408753", "lang": "en", "text": "In 2007 the ANU received it’s NEC 250 KV single stage accelerator mass spectrometer (SSAMS), dedicated to radiocarbon measurement. In brief, targets are loaded into the ion source and sputtered with a +ve cesium ions. This liberates –ve ions that are accelerated toward the injector magnet. The low energy bending magnet (LEBM) bends the beam to 90 degrees to select the mass of interest and energisizes the ions to ~37,000 V.\nOne analogy is a car (Carbon 12), a truck (Carbon 13) and a semi-trailor (Carbon 14) on a race track, due to their differnt weights, or masses, they will handle the turn differently. But back to our carbon ions in racing stripes. After the injection magnet, an Einzel lens (EL) is placed before the acceleration tube, focussing the beam through the argon stripper without changing the energy of the beam. The stripper, or molecular dissociator, breaks up isobaric interferences, such as hydrides, but also removes electrons changing the ions polarity. The high energy bending magnet (HEBM) then bends the +ve ions where we measure the carbon 12 and 13 currents in off-axis faraday cups. Carbon 14 continues down the beamline to be energy filtered at the electrostatic analyser (ESA) before the beam is directed into the silicon barrier detector. The stripper, high energy bending magnet (HEBM) and electrostatic analyser (ESA) are mounted on a high voltage insulated deck with a maximum of 250,000 V potential. This potential difference negates the need for the second acceleration used in tandem instruments. And yes, at those voltages it lives behind a cage.", "domain": "chemistry", "round": 3} +{"url": "https://www.steelestores.com/standard/jis-g3455/", "date": "2023-10-01T09:34:29Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233510810.46/warc/CC-MAIN-20231001073649-20231001103649-00873.warc.gz", "language_score": 0.757725179195404, "token_count": 1515, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__253723971", "lang": "en", "text": "JIS G3455 equivalent material\nThe JIS G3455 standard includes 6 grades. We can provide various grades of steel plates, steel coils, steel bars, structural steels (including special-shaped parts) under the CEN/TS 13388 standard in various conventional sizes. Customized processing and services , please send the specific requirements and drawings to the mailbox. After receiving it, we will confirm the plan and reply to you as soon as possible.\nJIS G3455 Introduction\nWe have been engaged in steel sales and processing since establishment. we have been experienced in supplying, can give strong support for clients in all kinds of information about JIS G3455, Provide high-quality JIS G3455 products, high-quality services,. We have complete quality control system, logistics system and after sales system to guarantee the smooth running of the whole process. Choosing us is choosing to rest assured.\nJIS G3455 equivalent material chemical element\nJIS G3455 in addition to carbon, steel also contains a small amount of manganese (Mn), silicon (Si), sulfur (S), phosphorus (P), oxygen (O), nitrogen (N) and hydrogen (H). These elements are not intentionally added to improve the quality of steel, but are brought in by ore and smelting process, so they are called impurity elements. These impurities have a certain impact on the properties of steel. In order to ensure the quality of steel, the chemical composition of all kinds of steel is strictly stipulated in technical standards.\nThe main elements proportion is as below:\n|JIS G3455 STS 370||C<0.2500, 1.1000>Mn>0.3000, P<0.0350, S<0.0350, 0.3500>Si>0.1000|\n|JIS G3455 STS410||C<0.3000, 1.4000>Mn>0.3000, P<0.0350, S<0.0350, 0.3500>Si>0.1000|\nJIS G3455 equivalent material mechanical\nThe main mechanical properties are elasticity, plasticity, stiffness, aging sensitivity, strength, hardness, impact toughness, fatigue strength and fracture toughness.\nElasticity: Metal material deforms when it is subjected to external force. When the external force is removed, it can restore its original shape.\nPlasticity: The ability of JIS G3455 to produce permanent deformation without causing damage under external forces.\nStiffness: The ability of JIS G3455 to resist elastic deformation under stress.\nStrength: The ability of JIS G3455 to resist deformation and fracture under external forces.\nHardness: The ability of JIS G3455 to resist the pressure of a harder object into it.\nImpact toughness: The ability of JIS G3455 to resist fracture under impact loading.\nFatigue strength: The maximum stress that does not cause fracture when JIS G3455 is subjected to numerous repeated or alternating loads.\nFracture toughness: a performance index used to reflect JIS G3455 is ability to resist crack instability and expansion\n|JIS G3455 STS 38||296 (≥)||177 (≥)||31||24||41||Solution and Aging, Annealing, Ausaging, Q+T,etc||321|\n|JIS G3455 STS 42||312 (≥)||987 (≥)||42||13||23||Solution and Aging, Annealing, Ausaging, Q+T,etc||243|\n|JIS G3455 STS 49||254 (≥)||769 (≥)||33||12||31||Solution and Aging, Annealing, Ausaging, Q+T,etc||111|\n|JIS G3455 STS 370||292 (≥)||794 (≥)||22||22||31||Solution and Aging, Annealing, Ausaging, Q+T,etc||444|\n|JIS G3455 STS410||754 (≥)||862 (≥)||11||43||44||Solution and Aging, Annealing, Ausaging, Q+T,etc||322|\n|JIS G3455 STS 480||535 (≥)||674 (≥)||22||41||32||Solution and Aging, Annealing, Ausaging, Q+T,etc||344|\nJIS G3455 equivalent material physical\nPhysical properties of JIS G3455 are mainly indicated by modulus of elasticity, thermal conductivity, specific thermal capacity, electrical resistance value, coefficient of thermal expansion, density, poisson's ratio, etc.\n|JIS G3455 STS 38||44||-||-||0.24||-|\n|JIS G3455 STS 42||33||-||-||0.33||-|\n|JIS G3455 STS 49||33||-||-||0.23||-|\n|JIS G3455 STS 370||24||-||-||0.14||-|\n|JIS G3455 STS410||14||-||-||0.32||-|\n|JIS G3455 STS 480||12||-||-||0.11||-|", "domain": "chemistry", "round": 3} +{"url": "https://www.rug.nl/research/portal/publications/photoactivation-of-mdm2-inhibitors(6a81f2b7-5b2b-457f-aa80-85ee9fed4252).html", "date": "2020-11-23T20:16:01Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-50/segments/1606141164142.1/warc/CC-MAIN-20201123182720-20201123212720-00426.warc.gz", "language_score": 0.8026424646377563, "token_count": 398, "dump": "CC-MAIN-2020-50", "global_id": "webtext-fineweb__CC-MAIN-2020-50__0__163046942", "lang": "en", "text": "Photoactivation of MDM2 Inhibitors: Controlling Protein-Protein Interaction with LightHansen, M. J., Feringa, F. M., Kobauri, P., Szymanski, W., Medema, R. H. & Feringa, B. L., 17-Oct-2018, In : Journal of the American Chemical Society. 140, 41, p. 13136-13141 6 p.\nResearch output: Contribution to journal › Article › Academic › peer-review\nSelectivity remains a major challenge in anticancer therapy, which potentially can be overcome by local activation of a cytotoxic drug. Such triggered activation can be obtained through modification of a drug with a photoremovable protecting group (PPG), and subsequent irradiation in the chosen place and time. Herein, the design, synthesis and biological evaluation is described of a photoactivatable MDM2 inhibitor, PPG-idasanutlin, which exerts no functional effect on cellular outgrowth, but allows for the selective, noninvasive activation of antitumor properties upon irradiation visible light, demonstrating activation with micrometer, single cell precision. The generality of this method has been demonstrated by growth inhibition of multiple cancer cell lines showing p53 stabilization and subsequent growth inhibition effects upon irradiation. Light activation to regulate protein-protein interactions between MDM2 and p53 offers exciting opportunities to control a multitude of biological processes and has the potential to circumvent common selectivity issues in antitumor drug development.\n|Number of pages||6|\n|Journal||Journal of the American Chemical Society|\n|Publication status||Published - 17-Oct-2018|\n- PHOTOREMOVABLE PROTECTING GROUPS, P53 PATHWAY, PRACTICAL SYNTHESIS, PHOTOPHARMACOLOGY, CYCLOADDITION, ACTIVATION, THERAPIES, STABILITY", "domain": "chemistry", "round": 3} +{"url": "https://www.thermofisher.com/antibody/product/Phospho-AKT-pThr308-Antibody-B18H12L21-Monoclonal/701052", "date": "2017-01-22T02:29:23Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-04/segments/1484560281331.15/warc/CC-MAIN-20170116095121-00562-ip-10-171-10-70.ec2.internal.warc.gz", "language_score": 0.8475642800331116, "token_count": 993, "dump": "CC-MAIN-2017-04", "global_id": "webtext-fineweb__CC-MAIN-2017-04__0__150736421", "lang": "en", "text": "Note: You clicked on an external link, which has been disabled in order to keep your shopping session open.\nImmunofluorescent analysis of AKT (pT308) was performed on 70% confluent log phase HeLa cells. The cells were fixed with 4% paraformaldehyde for 15 minutes, permeabilized with 0. 25% Triton™ X-100 for 10 minutes, and blocked with 5% BSA for 1 hour at room temperature. The cells were labeled with ABfinity™ AKT (pT308) recombinant rabbit monoclonal antibody (Product # 701052) at a dilution of 1:500 in 1% BSA and incubated for 3 hours at room temperature and then labeled with Alexa Fluor® 488 goat anti-rabbit IgG secondary antibody (Product # A11008) at a dilution of 1:400 for 30 minutes at room temperature (Panel a: green). Nuclei (Panel b: blue) were stained with SlowFade® Gold Antifade Mountant DAPI (Product # S36938). F-actin (Panel c: red) was stained with Alexa Fluor® 594 phalloidin (Product # A12381). Panel d is a merged image showing cytoplasmic and perinuclear localization of phosphorylated AKT (pT308). Panel e shows competition with the phospho-AKT (pT308) peptide. The images were captured using a Nikon microscope at 20X magnification.\n|Tested species reactivity||Human|\n|Host / Isotype||Rabbit / IgG|\n|Immunogen||Phosphopeptide corresponding to amino acids 304–312 of human AKT|\n|Contains||0.09% sodium azide|\n|Storage Conditions||Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C|\n|Tested Applications||Dilution *|\n|Flow Cytometry (Flow)||1:100-1:500|\n|Western Blot (WB)||1:500-1:5000|\n* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.\nABfinity™ recombinant antibodies are rabbit monoclonal antibodies, unmatched for producing superior results. ABfinity™ antibodies are developed by immunizing animals, screening for functionality, cloning the immunogen-specific antibody genes into high-level mammalian expression vectors, produced on a large scale, and purified with Protein A.\nABfinity™ monoclonal antibodies resemble rabbit monoclonals isolated from serum or produced by hybridomas, but demonstrate greater specificity and sensitivity. Because ABfinity™ recombinant antibodies are derived from cloned DNA sequences of the heavy and light antibody chains, they are not susceptible to cell-line drift or lot-to-lot variation, thus allowing for peak specificity and performance.\nIntact IgG appears on a non-reducing gel as ~150 kDa band and upon reduction generating a ~25 kDa light chain band and a ~50 kDa heavy chain.\nAKT also known as protein kinase B (PKB) or RAS-alpha, is an ubiquitous serine/threonine kinase that plays an important role in diverse biological responses such as regulation of metabolism, cell survival and growth by phosphorylating multiple proteins. This protein kinase is activated by insulin, PI3K, IGF1 and various other growth and survival factors. Akt promotes cell survival by inhibiting apoptosis through phosphorylation and inactivation of several targets, including forkhead transcription factors, and caspase-9. The AKT pathway is a major target for cancer drug discovery.\nFor Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.\nAKT1m; CAKT; MGC99656; PKB; PKB Akt; PKB alpha; PKB-ALPHA; PRKBA; protein kinase B alpha; proto-oncogene c-Akt; RAC; RAC alpha serine/threonine protein kinase; rac protein kinase alpha; RAC-ALPHA; RAC-PK-alpha; serine-threonine protein kinase; v-akt murine thymoma viral oncogene homolog 1; v-akt murine thymoma viral oncogene-like protein 1\nAKT; AKT1; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA", "domain": "chemistry", "round": 3} +{"url": "https://academic.naver.com/article.naver?doc_id=177633095", "date": "2018-07-17T08:26:48Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-30/segments/1531676589618.52/warc/CC-MAIN-20180717070721-20180717090721-00438.warc.gz", "language_score": 0.8486502766609192, "token_count": 304, "dump": "CC-MAIN-2018-30", "global_id": "webtext-fineweb__CC-MAIN-2018-30__0__47584221", "lang": "en", "text": "Effect of grain size on thermal shock property of alumina ceramic\n- Xianghong Xu, Shilong Sheng, Wenjun Yuan, Zhongkang Lin\n- International Journal of Computational Materials Science and Engineering\n- World Scientific Publishing in 2016\n- Cited Count\n- World Scientific\nCeramic has a great broad application in high-temperature environment due to its favorable mechanical, antioxidant and corrosion resistance properties. However, it tends to exhibit severe crack or fail under thermal shock resulting from its inherent brittleness. Microstructure property is a vital factor and plays a critical role in influencing thermal shock property of ceramic. The present study experimentally tested and characterized thermal-shock crack and residual strength of ceramic under different quench temperature, while two kinds of alumina ceramics with different grain size are employed. A two-dimensional (2D) numerical model based on statistical mesoscopic damage mechanics is introduced to depict the micro-crack propagation of ceramic sheet under water quenching. The effects of grain size on critical thermal shock temperature, crack characteristics and residual strength are studied. And the microscopic mechanism of the influence of grain size on thermal shock resistance of ceramic is discussed based on the crack propagation path obtained from experimental and simulation results. The qualitative effect and evolution change of grain size on thermal shock property of alumina ceramic will be summarized.\nNo relevant information is available\nIf you register references through the customer center, the reference information will be registered as soon as possible.", "domain": "chemistry", "round": 3} +{"url": "http://web.stanford.edu/group/gcep/cgi-bin/gcep-research/all/nanotube-networks-as-transparent-electrodes-for-solar-cells/", "date": "2017-03-28T06:25:06Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-13/segments/1490218189680.78/warc/CC-MAIN-20170322212949-00644-ip-10-233-31-227.ec2.internal.warc.gz", "language_score": 0.8361057639122009, "token_count": 477, "dump": "CC-MAIN-2017-13", "global_id": "webtext-fineweb__CC-MAIN-2017-13__0__221958657", "lang": "en", "text": "Michael McGehee, Assistant Professor, Department of Material Science & Engineering; David Goldhaber-Gordon, Assistant Professor, Department of Physics, Stanford University\nThis activity explores the use of transparent electrodes made of carbon nanotube (CNT) networks in organic photovoltaics (PVs). CNT-based electrodes have several potential advantages over standard transparent electrodes (such as Indium Tin Oxide) including an extraordinarily large electron mobility, increased contact area, and higher flexibility. This group will study the influence of film roughness on charge collection, film adhesion on the polymer layer, and film work function of the polymer-based PVs. Novel high spatial resolution microscopy techniques will be used to determine limiting factors of film conductivity. The experiments will strive to understand basic causes of low-conductivity found in current CNT films. These measurements will guide the fabrication of future CNT films, as well as provide leads on other forms of graphitic carbon nanostructures that enhance or outperform nanotubes. In addition, the development of scanning probe techniques for the transparent electrodes used here may assist in the investigation of other fundamental processes in excitonic solar cells, such as diffusion and recombination in the active layers.\n- Rowell, M. W., M. A. Topinka, M. D. McGehee, H. J. Prall, G. Dennler, N. S. Sariciftci, L. Hu, and G. Gruner. “Organic solar cells with carbon nanotube network electrodes.” Applied Physics Letters 88 (23), 233506-1-3, doi:10.1063/1.2209887 (2006).\n- McGehee, M. D. “Nanostructured Hybrid Organic-Inorganic Photovoltaic Cells,” Materials Research Society Meeting, San Francisco, CA, April 17-21, 2006.\n- Topinka, M. A., M. W.Rowell, M. D.McGehee, L. Hu, D. Hecht, and G.Gruner. “Carbon Nanotube Films as Flexible Transparent Conductors for Solar Cells,” American Physical Society March Meeting, Baltimore, MD, March 13-16, 2006.", "domain": "chemistry", "round": 3} +{"url": "https://www.genaxxon.com/shop/en/shop-all-products/cell-biology/cell-dissociation/1406/accutase-cell-detachment-solution", "date": "2023-12-11T16:18:10Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679515260.97/warc/CC-MAIN-20231211143258-20231211173258-00216.warc.gz", "language_score": 0.8233031630516052, "token_count": 472, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__39659436", "lang": "en", "text": "Order number: C4356.0100Shipping: shipped on wet ice, store at -20°C\nReady to ship today,\nDelivery time 1-3 workdays\nAccutase® as a cell detachment solution of proteolytic and collagenolytic enzymes useful for the routine detachment of cells from standard tissue culture plastic ware and adhesion coated plastic ware. The reagent is useful for creating single cell suspensions from clumped cell cultures for accurate cell counting, detachment of cells from primary tissue. It is much better suited for cell detachment than trypsin. Proven effective in detaching primary fibroblasts, endothelial cells, neurons, tumor cell lines, and insect cells.\nAccutase® does not contain mammalian or bacterial derived products. For that reason Accutase® virus or endotoxin contaminations are excluded. Once thawed Accutase® can be used for about 1 week if stored at +2°C to +8°C. Shelf-life at -20°C is 12 months.\nNote: Accutase is a registered trademark of Innovative Cell Technologies, Inc.\nReady-to-use liquid consisting of a proprietary mixture of proteolytic and collagenolytic enzymes\nPrepared in Dulbecco′s PBS (0.2g/L KCl, 0.2g/L KH2PO4, 8g/L NaCl, and 1.15g/L Na2HPO4) containing 0.5mM EDTA and Phenol Red.\npH: 6.6 - 7.6\nSterile filtered solution\nSuitable for cell culture\napplication:for use in dissociation of cells from standard and adhesion-coated plasticware\nSicherheits Hinweise / Safety\nKlassifizierungen / Classificationeclass-Nr: 32-16-08-90\nDokumente - Protokolle - Downloads\nHere you will find information and further literature on Accutase® Cell Detachment Solution. For further documents (certificates with additional lot numbers, safety data sheets in other languages, further product information) please contact Genaxxon biosience at: firstname.lastname@example.org or phone: +49 731 3608 123.", "domain": "chemistry", "round": 3} +{"url": "https://lktlabs.com/product/butein/", "date": "2023-03-24T15:23:36Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-14/segments/1679296945287.43/warc/CC-MAIN-20230324144746-20230324174746-00789.warc.gz", "language_score": 0.8674166798591614, "token_count": 317, "dump": "CC-MAIN-2023-14", "global_id": "webtext-fineweb__CC-MAIN-2023-14__0__8369223", "lang": "en", "text": "Butein is a flavonoid originally found in the bark of Rhus verniciflua and the flowers of Butea monosperma. Butein exhibits anticancer chemotherapeutic, anti-angiogenic, neuroprotective, anti-inflammatory, antioxidative, and anti-fibrotic activities. In lung cancer cells, butein decreases expression of COX-2, inducing cell cycle arrest and apoptosis; this compound also inhibits tumor growth of prostate cancer xenografts in vivo. Butein inhibits phosphorylation of Akt, mTOR, and their downstream targets and suppresses VEGF-induced cell proliferation, migration, and tube formation in endothelial progenitor cells; it also inhibits vessel sprouting from aortic rings in vivo. In animal models of spinal cord injury, butein decreases expression of NF-κB and IκBα, inhibits activation of caspase 3, and suppresses infiltration of neutrophils. In cellular models, this compound increases levels of glutathione and activity of catalase and glutathione S-transferase and decreases levels of lactate dehydrogenase. Butein also acts as a free radical scavenger. Additionally, butein prevents hepatic stellate cell (HSC) activation, downregulating expression of TGF-β, TIMP-1/2, and MMP-2 and inhibiting activation of NF-κB, p38, JNK, and Smad3.", "domain": "chemistry", "round": 3} +{"url": "https://dnagrade.com/our-catalog/132768-biomatik/135528-estrogen-receptor-beta-dna-binding-elisa-kit", "date": "2022-09-27T03:56:58Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-40/segments/1664030334987.39/warc/CC-MAIN-20220927033539-20220927063539-00032.warc.gz", "language_score": 0.7430979013442993, "token_count": 450, "dump": "CC-MAIN-2022-40", "global_id": "webtext-fineweb__CC-MAIN-2022-40__0__243066427", "lang": "en", "text": "Research Area NA\nQuality Systems NA\nCross Activity NA\nAssay Type NA\nStorage Temperature 4°C\nAssay Time 6 hours\nShipping Conditions Ice packs\nSample Type Cell lysate\nSpecies Reactivity Human, Mouse, Rat\nEstimated Turnaround Time 3-6 business days\nDetection Method Colorimetric 450 nm\nTarget Name Estrogen Receptor-beta\nDetection Range 10-30 ug of total protein/well\nTarget's alterntive name ESR2; ESTRB; Estrogen receptor beta; NR3A2\nApplication For research use only. Not for diagnostic procedures.\nTest ELISA Enzyme-linked immunosorbent assays Code 90320007 SNOMED\nShelf life Use Estrogen Receptor-beta DNA-Binding ELISA Kit before 6 months\nPrecaution of Use The Stop Solution is acidic. Do not allow to contact skin or eyes.\nTest Principle The Estrogen Receptor-beta DNA-Binding ELISA Kit qualitatively detects endogenous Estrogen Receptor-beta protein.\nProperties E05 478 566 350 170 or Enzyme-Linked Immunosorbent Assays,E05 478 566 350 170 or Enzyme-Linked Immunosorbent Assays\nDescription The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.", "domain": "chemistry", "round": 3} +{"url": "https://www.drugs.com/vet/gluquat-can.html", "date": "2023-09-29T09:59:26Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233510501.83/warc/CC-MAIN-20230929090526-20230929120526-00705.warc.gz", "language_score": 0.6808157563209534, "token_count": 900, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__36376498", "lang": "en", "text": "Gluquat (Canada)This page contains information on Gluquat for veterinary use.\nThe information provided typically includes the following:\n- Gluquat Indications\n- Warnings and cautions for Gluquat\n- Direction and dosage information for Gluquat\nGluquatThis treatment applies to the following species:\nFOR INDUSTRIAL AND INSTITUTIONAL USE ONLY\nREAD THE LABEL BEFORE USING\nGLUQUAT IS A GLUTARALDEHYDE/QUATERNARY AMMONIUM BASED DISINFECTANT USED FOR THE CLEANING AND DISINFECTION OF HOG AND POULTRY HOUSING FACILITIES, LIVESTOCK TRUCKS AND TRAILERS AND EQUIPMENT.\nPROVEN TO BE HIGHLY EFFECTIVE ON A WIDE RANGE OF BACTERIA AND VIRUSES INCLUDING E. COLI, SALMONELLA, LISTERIA AND CIRCOVIRUS.\nDIRECTION FOR USE\n1. Remove all animals and feed. Then remove all dirt, manure, debris from floor or surface.\n2. Pre-rinse with high pressure water to pre-clean.\n3. Clean with an alkaline cleaner (Premise Degreaser)\n4. Rinse with high pressure water.\n5. Apply GLUQUAT (as directed) to disinfect the cleaned surface by a foaming applicator. Use 20 mL of GLUQUAT per 5 litres of water (1:250). Allow a minimum contact time of 10 minutes.\n6. Allow the disinfected surface to air for 4 hours before admitting livestock.\nDO NOT STORE IN FOOD PROCESSING OR FOOD STORAGE AREAS.\nOctyl Decyl Dimethyl Ammonium Chloride\nDioctyl Dimethyl Ammonium Chloride\nDidecyl Dimethyl Ammonium Chloride\nAlkyl (C12, 40%, C14, 50%, C16, 10%) Dimethyl Benzyl Ammonium Chloride\nREFER TO MATERIAL SAFETY DATA SHEET\nIrritating to eyes and skin. Harmful if swallowed.\nWear rubber gloves and safety goggles when handling. KEEP OUT OF REACH OF CHILDREN\nFIRST AID MEASURES:\nIn case of accidental contact, flush with plenty of water. For eyes, if irritation persists, consult a physician. In case of ingestion, do not induce vomiting. Administer plenty of water or milk, call a physician.\nMANUFACTURED BY: WEST PENETONE INC., 10,900 rue Secant Street, Montreal (Anjou), QC H1J 1S5\n(514) 355-4660 - 800 361-8927\nBranches in principal cities.\nNET CONTENTS: 4x4 L case, 20 L pail, 55 L keg, 205 L drum\nProduct code: 1117\nMADE IN CANADA\n10,900 SECANT STREET, MONTREAL (ANJOU), QC, H1J 1S5\nCopyright © 2023 Animalytix LLC. Updated: 2023-05-29", "domain": "chemistry", "round": 3} +{"url": "https://rarpolymer.princeton.edu/research/completed-projects/rheology", "date": "2023-09-21T22:02:33Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233506045.12/warc/CC-MAIN-20230921210007-20230922000007-00200.warc.gz", "language_score": 0.8121888637542725, "token_count": 742, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__127949490", "lang": "en", "text": "Despite the widespread application of block copolymers, their rheology in the two-phase state, characterized by large viscosities and elasticities, has only recently yielded to understanding. We investigated the flow behavior of sphere-forming block copolymers. In the ordered state, at low shear stresses, the microdomains are ordered, giving the molten rubber a large viscosity. However, as shown in the figure below, at a critical shear stress the viscosity drops precipitously as the microdomains are \"shear-disordered\". We showed that this stress is uniquely related to the spacing between ordered microdomains, allowing us to control the value of this stress through molecular design or the addition of a selective solvent.\nSupported by the National Science Foundation, Materials Research Science and Engineering Center (MRSEC) Program, through the Princeton Center for Complex Materials\nGroup Members Involved, and Their Project Titles:\nDaniel Vega PDRA – “Phase Behavior and Rheology of Block Copolymer Gels”\nJohn Sebastian PhD *01 – “Rheology of Spherical-Phase Block Copolymer Melts and Solutions”\nJ. LaMonte Adams PhD *96 – “Rheology and Phase Behavior of Styrene-Diene Block Copolymers”\nRelevant Group Publications:\nJ.M. Sebastian, W.W. Graessley, and R.A. Register, “Steady-Shear Rheology of Block Copolymer Melts and Concentrated Solutions: Defect-Mediated Flow at Low Stresses in Body-Centered-Cubic Systems”, J. Rheol., 46, 863-879 (2002).\nJ.M. Sebastian, C.J. Lai, W.W. Graessley, and R.A. Register, “Steady-Shear Rheology of Block Copolymer Melts and Concentrated Solutions: Disordering Stress in Body-Centered-Cubic Systems”, Macromolecules, 35, 2707-2713 (2002).\nJ.M. Sebastian, C.J. Lai, W.W. Graessley, and R.A. Register, “Steady-Shear Rheology of Block Copolymer Melts: Zero-Shear Viscosity and Shear-Disordering in Body-Centered-Cubic Systems”, Macromolecules, 35, 2700-2706 (2002).\nD.A. Vega, J.M. Sebastian, Y.-L. Loo, and R.A. Register, “Phase Behavior and Viscoelastic Properties of Entangled Block Copolymer Gels”, J. Polym. Sci. B: Polym. Phys., 39, 2183-2197 (2001).\nJ.L. Adams, D.J. Quiram, W.W. Graessley, R.A. Register, and G.R. Marchand, “Ordering Dynamics of Compositionally Asymmetric Styrene-Isoprene Block Copolymers”, Macromolecules, 29, 2929-2938 (1996).\nJ.L. Adams, W.W. Graessley, and R.A. Register, “Rheology and the Microphase Separation Transition in Styrene-Isoprene Block Copolymers”, Macromolecules, 27, 6026-6032 (1994).", "domain": "chemistry", "round": 3} +{"url": "http://eprints.uniss.it/10737/", "date": "2019-07-23T15:41:03Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-30/segments/1563195529480.89/warc/CC-MAIN-20190723151547-20190723173547-00005.warc.gz", "language_score": 0.7089788317680359, "token_count": 250, "dump": "CC-MAIN-2019-30", "global_id": "webtext-fineweb__CC-MAIN-2019-30__0__79775559", "lang": "en", "text": "Budroni, Marcello Antonio and Lemaigre, L. and De Wit, Anne and Rossi, Federico (2015) Cross-diffusion-induced convective patterns in microemulsion systems. Physical Chemistry Chemical Physics, Vol. 17 (3), p. 1593-1600. ISSN 1463-9076. eISSN 1463-9084. Article.\nFull text not available from this repository.\nCross-diffusion phenomena are experimentally shown to be able to induce convective fingering around an initially stable stratification of two microemulsions with different compositions. Upon diffusion of a salt that entrains water and AOT micelles by cross-diffusion, the miscible interface deforms into fingers following the build-up of a non-monotonic density profile in the gravitational field. A diffusion model incorporating cross-diffusion effects provides an explanation for the mechanism of the buoyancy-driven hydrodynamic instability and for the properties of the convective fingers.\nI documenti depositati in UnissResearch sono protetti dalle leggi che regolano il diritto d'autore\nRepository Staff Only: item control page", "domain": "chemistry", "round": 3} +{"url": "https://www.chandranlab.org/basu2015", "date": "2019-09-21T23:48:11Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-39/segments/1568514574710.66/warc/CC-MAIN-20190921231814-20190922013814-00515.warc.gz", "language_score": 0.9083181023597717, "token_count": 341, "dump": "CC-MAIN-2019-39", "global_id": "webtext-fineweb__CC-MAIN-2019-39__0__26423308", "lang": "en", "text": "Background | The current Ebola virus (EBOV) outbreak has highlighted the troubling absence of available antivirals or vaccines to treat infected patients and stop the spread of EBOV. The EBOV glycoprotein (GP) plays critical roles in the early stage of virus infection, including receptor binding and membrane fusion, making it a potential target for the development of anti-EBOV drugs. We report the identification of 2 novel EBOV inhibitors targeting viral entry.\nMethods | To identify small molecule inhibitors of EBOV entry, we carried out a cell-based high-throughput screening using human immunodeficiency virus–based pseudotyped viruses expressing EBOV-GP. Two compounds were identified, and mechanism-of-action studies were performed using immunoflourescence, AlphaLISA, and enzymatic assays for cathepsin B inhibition.\nResults | We report the identification of 2 novel entry inhibitors. These inhibitors (1) inhibit EBOV infection (50% inhibitory concentration, approximately 0.28 and approximately 10 µmol/L) at a late stage of entry, (2) induce Niemann-Pick C phenotype, and (3) inhibit GP–Niemann-Pick C1 (NPC1) protein interaction.\nConclusions | We have identified 2 novel EBOV inhibitors, MBX2254 and MBX2270, that can serve as starting points for the development of an anti-EBOV therapeutic agent. Our findings also highlight the importance of NPC1-GP interaction in EBOV entry and the attractiveness of NPC1 as an antifiloviral therapeutic target.", "domain": "chemistry", "round": 3} +{"url": "https://valve-automatic.com/rubber-pinch-valve/", "date": "2023-12-10T05:40:57Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679101195.85/warc/CC-MAIN-20231210025335-20231210055335-00865.warc.gz", "language_score": 0.921923816204071, "token_count": 1506, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__246049614", "lang": "en", "text": "Exploring the Benefits of Installing a Rubber Pinch Valve\nRubber pinch valves have become increasingly popular in recent years. As an effective and versatile solution for flow control in a variety of industrial applications. These valves operate by pinching a flexible rubber tube to control the flow of fluid. Making them ideal for handling abrasive, viscous, and corrosive materials. In this blog post, we will explore the many benefits of installing a rubber pinch valve. Including their flexible and durable construction, excellent flow control properties, chemical. And abrasion resistance, and low maintenance requirements. We will also discuss the different industries that use rubber pinch valves. As well as how they compare to other valve types in terms of efficiency and effectiveness. Finally, we will provide insights into the installation and maintenance of rubber pinch valves. Offering tips on how to extend their life and overcome common maintenance challenges.\nII. Advantages of Rubber Pinch Valves\nPinch valve offer various benefits that make them an attractive option for many industrial applications. Firstly, they have a flexible and durable construction that can withstand high pressure and high-temperature environments. The valve’s flexible rubber sleeve allows it to maintain its shape. Even when faced with high-pressure fluids, ensuring optimal performance and extending the life of the valve. Furthermore, rubber pinch valves provide excellent flow control, minimizing turbulence and maximizing flow rates, leading to improved process efficiency.\nAnother advantage is their chemical and abrasion resistance, making them ideal for handling corrosive and abrasive materials. Rubber pinch valves can be constructed with several types of elastomers. Each designed to resist a specific chemical or temperature range, allowing them to handle a wide range of corrosive and abrasive fluids. Additionally, rubber pinch valves require minimal maintenance due to their simple design. Resulting in a lower cost of ownership and fewer scheduled maintenance activities, decreasing production downtime, and increasing plant productivity levels.\nFinally, pneumatic pinch valves offer a long service life, which reduces the frequency of replacements and saves operating costs. These valves are dependable, rugged, and have been proven to last for many years continuously with minimal damage or wear. Their construction materials and design features result in a reliable product. Offering a cost-effective solution for flow control in numerous industrial applications. In conclusion, the advantages of using rubber pinch valves ensure continuous effective performance and maximum flow control. Making them a preferred choice for many industrial processes.\nIII. Applications of Rubber Pinch Valves\nRubber pinch valves are suitable for a wide range of industries and applications where abrasive, viscous, and corrosive fluids need to be controlled efficiently. One of the most common sectors where rubber pinch valves are utilized is mining. These valves are ideal for handling slurries, waste liquids, and effluent streams in mining applications, where reliability and durability are essential. The wastewater treatment industry also uses rubber pinch valves due to their chemical resistance and easy maintenance requirements.\nFood processing is another sector where rubber pinch valves often use. To control the flow of viscous fluids like tomato paste, cheese, and syrups. The pulp and paper industry also uses rubber pinch valves in many different applications. Like pulp and paper production, dewatering, and sludge handling.\nMoreover, these valves use in the oil and gas industry. Specifically for high solid concentrations slurry, solids recoveries, and tailings control applications. Other industries, including chemicals, pharmaceuticals, and power plants. Also rely on rubber pinch valves for their efficient and reliable fluid control. In conclusion, rubber pinch valves serve in various industries and applications. Making them a versatile and flexible solution for flow control.\nIV. Comparison to Other Valve Types\nRubber pinch valves differ from other valve types such as globe valves, gate valves, and diaphragm valves. Using their flexible rubber tube design to control the flow of fluids. Compared to globe valves, which tend to be more complex. And gate valves that use a gate-like mechanism to open and close the valve, rubber pinch valves are simpler in design. Making them easy to operate and maintain. Diaphragm valves have also become increasingly popular because of their ability to handle highly corrosive fluids. However, rubber pinch valves have a significant advantage in handling abrasive fluids. Due to their design that allows for easy and simple replacement of the rubber hose.\nAdditionally, diaphragm valves hold a higher cost of ownership due to the costly replacement of the machined diaphragm. In contrast, rubber pinch valves, which are constructed of fewer parts, are more accessible, and therefore less expensive to maintain. Furthermore, the simple design of rubber pinch valves allows for high-pressure applications. Making them well suited for environments where other types of valves would typically fail. The construction of rubber pinch valves using elastomers contributes significantly to their chemical and abrasion resistance. It is essential in the handling of corrosive fluids. In summary, rubber pinch valves stand out from other valve types. Being simple to operate and maintain, good at handling abrasive fluids, and having low ownership costs.\nV. Installation and Maintenance\nProper installation and maintenance of rubber pinch valves are essential for ensuring optimal performance and a long service life. During installation, it is crucial to select the appropriate valve size for the application. And ensure proper alignment of the valve body and pipe flanges. Once installed, regular maintenance procedures are essential to keep the valve functioning correctly. The maintenance procedure for rubber pinch valves is simple and straightforward. It often requiring only the replacement of the rubber tubing, which is cost-effective compared to other valve types. The frequency of maintenance is dependent on several factors. Such as the fluid’s corrosiveness, the frequency of use, and the environment.\nIt is also essential to avoid exposing rubber pinch valves to extreme temperatures and harsh operating conditions. It can accelerate rubber wear or compromise the structural integrity of the valve. Furthermore, inspecting the rubber sleeve and replacing it when needed can minimize maintenance challenges and prolong the valve’s life. Finally, before undertaking maintenance, it is recommended that the rubber pinch valve. It isolate and depressurized to minimize equipment damage or worker injury.\nUsing the recommended manufacturer’s replacement parts and following manufacturer maintenance recommendations. Rubbers pinch valves can provide many years of reliable service. Maintaining proper records of maintenance and replacement of parts is critical for maintaining valve records and ensuring optimum service. In conclusion, Installation and maintenance of rubber pinch valves are straightforward and simple. Making it easier to maintain and operate than other valve types, resulting in cost-effectiveness and efficient operation.\nIn conclusion, rubber pinch valves have become increasingly popular due to their flexible and durable construction, excellent flow control properties, chemical and abrasion resistance, and low maintenance requirements. They are used by a wide range of industries. Such as mining, wastewater treatment, food processing, pulp and paper, and oil and gas. Compared to other valve types, rubber pinch valves offer several benefits, including simpler design, high-pressure capabilities, and lower ownership costs.\nProper installation and maintenance procedures, including selecting the correct valve size. Avoiding harsh operating conditions, inspecting the rubber sleeve, and using recommended replacement parts. Contribute to rubber pinch valve’s long service life and optimal performance. Therefore, rubber pinch valves are an attractive fluid control solution for industries focused on reliability, cost-effectiveness, and efficiency.", "domain": "chemistry", "round": 3} +{"url": "http://www.genetex.com/NAT5-antibody-N1C3-GTX116136.html", "date": "2017-03-27T08:33:44Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-13/segments/1490218189466.30/warc/CC-MAIN-20170322212949-00628-ip-10-233-31-227.ec2.internal.warc.gz", "language_score": 0.711225688457489, "token_count": 522, "dump": "CC-MAIN-2017-13", "global_id": "webtext-fineweb__CC-MAIN-2017-13__0__32927545", "lang": "en", "text": "|Full Name||N(alpha)-acetyltransferase 20, NatB catalytic subunit|\n|Product Description||Rabbit polyclonal antibody to NAT5 (N-acetyltransferase 5 (GCN5-related, putative))|\n|Background||NAT5 is a component of N-acetyltransferase complex B (NatB). Human NatB performs cotranslational N(alpha)-terminal acetylation of methionine residues when they are followed by asparagine (Starheim et al., 2008 [PubMed 18570629]).[supplied by OMIM]|\n|Synonyms||NAT3 antibody, NAT5 antibody, dJ1002M8.1 antibody, NAA20 antibody, \"N-alpha-acetyltransferase 20, NatB catalytic subunit antibody\", N-terminal acetyltransferase B complex catalytic subunit NAT5 antibody, \"N-acetyltransferase 5 (ARD1 homolog, S. cerevisiae) antibody\", N-terminal acetyltransferase complex ARD1 subunit antibody, \"N-acetyltransferase 5 (GCN5-related, putative) antibody\", \"N-acetyltransferase 5, ARD1 subunit (arrest-defective 1, S. cerevisiae, homolog) antibody\", N-terminal acetyltransferase B complex catalytic subunit NAA20 antibody, N-acetyltransferase 3 homolog antibody, natB complex subunit NAT5 antibody, N-alpha-acetyltransferase 20 antibody, natB catalytic subunit antibody, \"N(alpha)-acetyltransferase 20, NatB catalytic subunit antibody\"|\n|Immunogen||Recombinant protein encompassing a sequence within the center region of human NAT5. The exact sequence is proprietary.|\n|Predicted Cross Reactivity species Predicted cross-reactivity:|\nPredicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.\nPlease note that we are only able to guarantee products to work in applications and species in which they have been tested.\n|Human, Mouse, Rat, Zebrafish, Xenopus laevis, Bovine|\n|Predict Reactivity Note||Human (100%), Mouse (100%), Rat (99%), Zebrafish (98%), Xenopus laevis (99%), Bovine (100%)|", "domain": "chemistry", "round": 3} +{"url": "http://www.cellsignal.com/products/9796.html", "date": "2013-06-20T05:04:52Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2013-20/segments/1368710299158/warc/CC-MAIN-20130516131819-00069-ip-10-60-113-184.ec2.internal.warc.gz", "language_score": 0.7314125895500183, "token_count": 577, "dump": "CC-MAIN-2013-20", "global_id": "webtext-fineweb__CC-MAIN-2013-20__0__179783426", "lang": "en", "text": "Product Pathways - Metabolism\nACAD9 Antibody #9796\n|W||H M R Mk||Endogenous||69||Rabbit|\nReactivity Key: H=Human M=Mouse R=Rat Mk=Monkey\nSpecies cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.\nSpecificity / Sensitivity\nACAD9 Antibody recognizes endogenous levels of total ACAD9 protein.\nSource / Purification\nPolyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val512 of human ACAD9 protein. Antibodies are purified by protein A and peptide affinity chromatography.\nWestern blot analysis of extracts from 293 cells, mock transfected (-) or transfected with a construct expressing DDK-tagged full-length human ACAD9 (hACAD9-DDK; +), using ACAD9 Antibody (upper), DYKDDDDK Tag (9A3) Mouse mAb #8146 (middle), or β-Actin (D6A8) Rabbit mAb #8457 (lower).\nThe mitochondrial flavoenzymes acyl-CoA dehydrogenases (ACADs) catalyze the α,β dehydrogenation of acyl-CoA esters (1). One of these enzymes, ACAD9, is essential for assembly of oxidative phosphorylation complex I (2). Studies have shown that ACAD9 gene mutations cause Complex I deficiency (2,3).\n- He, M. et al. (2007) Am J Hum Genet 81, 87-103.\n- Nouws, J. et al. (2010) Cell Metab 12, 283-94.\n- Haack, T.B. et al. (2010) Nat Genet 42, 1131-4.\nHave you published research involving the use of our products? If so we'd love to hear about it. Please let us know!\n- 9997 Tris Buffered Saline with Tween 20 (TBST-10X)\n- 9998 BSA\n- 9999 Nonfat Dry Milk\n- 7071 Phototope®-HRP Western Blot Detection System, Anti-rabbit IgG, HRP-linked Antibody\n- 7074 Anti-rabbit IgG, HRP-linked Antibody\n- 7720 Prestained Protein Marker, Broad Range (Premixed Format)\n- 7727 Biotinylated Protein Ladder Detection Pack\n- 7003 20X LumiGLO® Reagent and 20X Peroxide\nFor Research Use Only. Not For Use In Diagnostic Procedures.", "domain": "chemistry", "round": 3} +{"url": "https://yinyangnails.com/how-does-acetone-damage-your-nails/", "date": "2023-02-01T09:03:29Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-06/segments/1674764499919.70/warc/CC-MAIN-20230201081311-20230201111311-00767.warc.gz", "language_score": 0.9382564425468445, "token_count": 3569, "dump": "CC-MAIN-2023-06", "global_id": "webtext-fineweb__CC-MAIN-2023-06__0__9326028", "lang": "en", "text": "- Is Acetone Safe to Use on Your Nails?\n- acetone is a solvent\n- acetone can cause dermatitis\n- acetone can cause nail infections\n- acetone can cause dehydration\n- How Do You Remove Nail Glue After Wearing False Nails?\n- Protecting your nails with hand gloves\n- Removing nail glue with aloe vera\n- removing it with acetone\nIs Acetone Safe to Use on Your Nails?\nDo you wonder if acetone is safe to use on your nails? There are several reasons why you should not use this solvent on your nails. In addition to damaging your nails, acetone can lead to dermatitis, nail infections, and dehydration. This article will explain what you should do instead. We will also discuss why acetone is not a good choice for nail care. The bottom line: don’t use acetone on your nails!\nacetone is a solvent\nIf you’ve ever tried to remove nail polish with acetone, you know its damages your hands. But what exactly is acetone, and why is it bad for you? First, it’s a solvent, which means that it’s poisonous. Acetone is a colorless liquid that breaks down other substances, including paint and varnish. However, it’s also a natural substance in the human body. This substance is made when the body breaks down food and fats into glucose and insulin, which the cells use to store energy and produce energy.\nAcetone is also a solvent that can damage your nails. Gel, SNS, and shellac are all products that stick to the nail plate. They must be soaked in acetone for at least 10 minutes before removal. Long-term exposure to acetone has been linked to splitting, discoloration, and overall thinning of the nails. Also, the skin on your fingertips can dry out and turn white. No one wants that!\nWhile acetone is a solvent that can damage your hands and nails, it is a safe solvent in small amounts. Although it may cause dermatitis, acetone is relatively safe in moderate amounts and is found in many household products. Even though it can be damaging, acetone poisoning is rare and has symptoms including headache, slurred speech, and a sweet taste in the mouth.\nOne of the main reasons acetone is terrible for your nails is because of the amount of drying it causes. When you soak your nails in acetone, they will be significantly drier and more prone to breakage, splitting, and peeling. Even worse, acetone can also damage your cuticles and lead to infections and bleeding. So, when you remove nail polish with acetone, make sure to use it in a well-ventilated area.\nWhile acetone is a solvent that can damage your fingers, it is also an excellent solvent for oil stains and varnish. It breaks down these materials, which makes them easier to remove. It’s used to degreasing and gum silk and wool in the textile industry. It also works excellent as a fingernail polish remover and can reduce the viscosity of lacquer solutions.\nacetone can cause dermatitis\nThere are many dangers of acetone on the skin. This solvent can cause skin damage because it dries the skin and depletes its natural oils. Exposure to acetone can also cause respiratory problems. This chemical is very hazardous to your health, and it is essential to get medical attention if you are exposed to a large amount of it. If you have skin problems, contact dermatitis can develop.\nWhile it is not dangerous in moderate amounts, exposure to acetone can be harmful to the eyes, nose, and throat. It is also likely to induce a reaction that results in dermatitis. At the same time, acetone is safe in moderation by wearing rubber gloves. Use a safe cleaning product or wash your hands thoroughly after applying acetone to prevent skin problems. Use protective clothing or a mask when working with acetone.\nAvoid the use of acetone in nail polish remover or other similar products. This substance is known to be absorbed by the body and is a common solvent in cosmetics. It is used to remove nail polish, shrink pimples, and dry skin oil. It may lead to dermatitis if you use it on your hands. If you must use acetone to remove paint, you should wear gloves with a protective gel barrier.\nThere are many other risks of acetone and atopic dermatitis, including atopic dermatitis and contact dermatitis. Avoid atopic dermatitis by washing your hands with a mild soap that does not contain acetone. It will protect your skin from irritation and potential bacterial infection. When appropriately used, acetone and other organic solvents can cause dermatitis in people.\nIt is best to limit the amount of acetone you use when applying nail polish, as this can cause dry skin. You should only apply nail polish remover that does not contain acetone and apply moisturizer to the exposed area afterward. You should also remove any contaminated clothing or shoes you may have worn. Taking off your shoes and clothes can also reduce your risk of developing dermatitis.\nacetone can cause nail infections\nMany household products contain acetone, a flammable and harsh liquid that can damage your nails and cuticles. While acetone is harmless in small amounts, it can be detrimental when ingested. It dehydrates the skin on the nails, resulting in dry, damaged, and brittle nails. It can also lead to infections and painful hangnails. Here are some things you need to know about this substance.\nAcetone is particularly harmful when applied to the skin. Not only does it cause dry, brittle nails, but it can also lead to troublesome contact dermatitis. Furthermore, prolonged exposure to acetone can result in broken skin that becomes a portal for infection. While acetone is generally safe to use, you should avoid using it when removing your acrylic nails. Instead, use a non-acetone-based nail polish remover. After removing your acrylic nail polish, wash the affected area thoroughly. Apply a moisturizer to the skin to prevent any further damage. Also, make sure you take off all clothing that may have been contaminated with acetone. Moreover, wear protective gloves and shoes whenever you use acetone-based products.\nThose with metabolic disorders should avoid using acetone. It can be harmful to the skin in the mouth and the esophagus lining. If you think that you have ingested acetone, immediately seek medical attention. If you tend to lick your fingers, wear rubber gloves. A small amount of acetone is harmless when absorbed by the body, but high levels can lead to serious health problems.\nFungal infections are also a risk factor. While they are not as common as fungal ones, they are more likely to occur in people who have artificial fingernails. The fungus can invade the nail bed and cause the nails to become thick and discolored. If the condition is severe, the infection may require antifungal medications. These medications are often only available with a doctor’s prescription. However, if the symptoms persist, you should seek medical attention right away.\nacetone can cause dehydration\nWhile acetone is not toxic, it can severely dry out your nail plate, cuticles, and surrounding skin. This substance is also known to cause painful reactions such as irritant contact dermatitis. Moreover, excessive exposure to acetone can lead to brittle, split, and peeling nails. Not to mention, acetone can cause your skin to turn white. Nevertheless, it’s not the biggest concern in nail cosmetics.\nAlthough acetone is effective at removing polish, it can cause damage to your nails. If you’re an avid painter, you might have noticed that your nail beds appear dehydrated after a while. Acetone is the primary culprit. An excellent alternative to acetone is hydrogen peroxide. This chemical is gentler on your nails than acetone, but it can cause dehydration.\nAlthough acetone is relatively safe for nail polish remover, you must always follow the instructions provided by the manufacturer. Moreover, it is highly flammable, so keep your workspace well ventilated, and wear protective safety glasses. Also, keep children away from acetone. It is highly volatile and can cause severe burns. The dangers of acetone poisoning are genuine and may result in severe health problems.\nAnother symptom of dehydration is dry cuticles. If this happens, you need to drink water or moisturizer to prevent the cuticles from becoming dehydrated to the nails. It requires UV light to cure. Wear a UV-blocking glove during the process to avoid exposure to the sun. Make sure you use sunscreen as well. The nail prep process can reduce the effectiveness of sunscreen.\nACEtone is one of the most common ingredients in nail polish remover. It is a powerful solvent that can easily dissolve tough stains, remove paint from furniture, and even degrease your skin. However, some people are sensitive to this ingredient and cannot use it on their nails. Furthermore, acetone can also damage the nail bed and your nails. Therefore, it is best to consult a nail professional before using acetone on your nails.\nHow Do You Remove Nail Glue After Wearing False Nails?\nHow do you remove nail glue after wearing false fingernails? Here are a few methods:\n- Use warm water to soften the glue on your nails.\n- Using acetone-based nail polish remover.\n- Gently prying at the base of the nail.\nPress-on nails should come off without much hassle. If you’re worried about damaging your natural nails, consider wearing hand gloves and applying aloe vera on them to prevent damage.\nThe quality of the bond will determine which method will work best for you. Filing your nails with a file is also an option, but be careful not to damage the nails. After removing nail glue, hydrate the nails if desired. However, if you don’t want to use acetone, use petroleum jelly or oil to remove any remaining adhesive.\nIt’s essential to avoid contact with acetone because it is highly flammable and can cause burns to your hands and nails. It can also irritate your skin. Use a cuticle stick to remove any remaining glue. Remember, acetone can also cause skin irritation and dryness. Make sure to use a glove or a disposable bowl. It would help if you also covered the table using acetone to avoid damaging it.\nIt would help if you also kept in mind that acetone can damage your natural nails over time. Hence, it would help if you used a protective glove or a mask to keep yourself from breathing the toxic fumes of acetone. If you cannot remove the nail glue using an acetone-based nail polish remover, you should consult a doctor to determine whether it’s safe for you to continue wearing false nails.\nIf you cannot remove the false nails with the acetone-based remover, you can apply cuticle oil to your cuticles and moisturize your hands.\nIf you’re worried that the fake nails you’ve just purchased will damage your natural nails, you can use a nail file to remove them. If you are concerned that your fake nails will stick to your natural nails, you can also use a nail buffer to remove the shine. Once you’ve finished cleaning your artificial nails, you can apply a clear topcoat to protect them from future damage.\nProtecting your nails with hand gloves\nYou may be wondering if hand gloves are necessary when wearing false nails. The answer is yes! But why should you wear them? Here are a few reasons to do so:\n- Gloves protect your nails from chemical agents that can damage your natural ones.\n- They help you remove excess nail glue and prevent chipping.\n- They help prevent water from penetrating your false nails.\nThese are just a few reasons why hand gloves are necessary for your nails after wearing false nails.\nWhen using nail products, you must always use appropriate gloves. Most gloves do not withstand strong chemicals. This means that you should always wear gloves while doing household chores. Moreover, gloves also help protect your nails from chipping. Furthermore, you can also buy a nail strengthener or acrylic powder to protect your nails from these harsh substances. Use these products daily or every other day to protect your nails. Also, choose organic or vegan nail polish to avoid harmful chemicals.\nWhen wearing false nails, it is essential to consider your surroundings and the type of gloves you wear. While wearing gloves, you should avoid touching the pins with your hands because you might get contaminated with chemicals and germs. Also, wearing gloves helps you avoid the possibility of skin sensitivity. It is also good to protect your nails before getting them done. A nail tech may use high-quality acrylics and not protect your hands if you don’t wear gloves.\nYou should wear hand gloves after wearing false nails to prevent chemical contact with your nails. Because acrylic nails are often prone to breaking, it’s essential to wear gloves when doing jobs involving water. The gloves will protect your nails from water and protect your nails from other chemicals that may damage your false nails. You should also keep your false nails dry so that they last longer.\nRemoving nail glue with aloe vera\nIf you are thinking about wearing false nails, you may be wondering how to remove nail glue afterward. Although several products can help you, the most effective and most comfortable method involves using high-quality nail glue. Look for nail glue made for your specific nails and contains ingredients like aloe vera, which strengthens your nails. Afterward, it would help if you used a clean toothbrush to scrape off any remaining adhesive gently.\nUsing hand lotion is another effective way of removing nail glue. First, make sure that you use the right amount of hand lotion. Gently massage the hand lotion into the area with circular motions. You can then wash your hands with soap and water. If necessary, you can apply other hand lotion to your hands to keep them moisturized. If these methods do not work, you can always use petroleum jelly instead.\nAnother effective way to remove the glue is to soak the false nails with nail polish remover. This type of nail glue remover contains acetone and water. It is essential to avoid nail glue removers that contain acetone because it has powerful chemicals. Remember to take a break from fake nails for two to three days after removing them. During this time, try to avoid pulling them off, as this can damage the skin.\nYou can remove them using olive oil and warm water if you have press-on nails. The olive oil will moisturize your natural nails, while the acetone-based remover will loosen the glue. After this, you can use a soft nail buffer to remove any remaining adhesive. To finish, you can apply cuticle oil and hand cream to help restore your natural nails with moisture.\nremoving it with acetone\nIf you’ve been wearing fake gel or acrylic nails for several weeks, you might want to remove the glue afterward with acetone. If you have trouble removing it yourself, you can purchase pure acetone from a drugstore or supermarket. Then, soak cotton pads or microfiber cloth in the acetone for about fifteen minutes. If you’re worried about acetone affecting your natural nail, you should buy a microfiber cloth to prevent dust from clogging the acetone.\nAfter wearing false nails, you can also remove nail glue by gently filing them off using acetone. While this method isn’t completely painless, it’s the least damaging. You can also try to remove false nails. It’s an excellent way to save money and time! Just be sure not to apply too much acetone. Otherwise, the acetone-based products might ruin your nails.\nAfter removing acetone from false nails, you should wash your hands with soap and water. You can also use a natural soap to moisturize your hands since acetone can dry out your skin. Natural oils like olive oil and almond oil can help restore moisture and soothe your skin after acetone removal. If you do not have a natural soap, you can still use petroleum jelly to rehydrate your hands.\nAfter wearing press-on nails, you can remove them using acetone-based nail polish remover. Using the same solution will help break down the adhesive and loosen your nails. You can also use a soft nail buffer to remove any remaining glue. If you’re unsure if your press-on nails will fall off on their own, soak them in warm water and apply some cuticle oil.\nAnother method to remove false nails is to apply petroleum jelly to your fingers. It will protect the skin around your nails from acetone. After 10 minutes, you can remove the affected fingernails using nail polish remover. You can also apply petroleum jelly to your fingers to protect them from harsh chemicals. These methods should remove the glue from your fingernails without causing any further damage.", "domain": "chemistry", "round": 3} +{"url": "https://www.indotrading.com/globalcool1/chemours-22-p747591.aspx", "date": "2021-10-27T19:54:06Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-43/segments/1634323588242.22/warc/CC-MAIN-20211027181907-20211027211907-00405.warc.gz", "language_score": 0.830214262008667, "token_count": 803, "dump": "CC-MAIN-2021-43", "global_id": "webtext-fineweb__CC-MAIN-2021-43__0__148461924", "lang": "en", "text": "Refrigerant Chemours 22\n- Trade Name: HCFC-22 (R22)\n- Chemical Name: CHLORODIFLUOROMETHANE\n- % Volatile: 100 WT %\n- Solubility in Water: 0.3 WT % at 25 deg C (77 deg F)\n- Odor: Slight ethereal\n- Form: Liquefied gas\n- Color: Clear, colorless\n- Boiling Point: -40.8 deg C (-41.4 deg F)\n- Vapor Pressure: 151 psig at 25 deg C (77 deg F)\n- Vapor Density: 3.03 at 25 deg C (Air = 1)\n- Liquid Density: 1.194 g/cm(3) at 25 deg C (77 deg F)\nFIRE AND EXPLOSION HAZARD DATA\nFlash Point - Will not burn Flammable Limits Autoignition - 632 C (1170 F)\nFire and Explosion Hazards - Cylinders may rupture under fire conditions. Decomposition may occur.\nExtinguishing Media - As appropriate for combustibles in area.\nSpecial Fire Fighting Procedures - Cool cylinders with water spray. Self-contained breathing apparatus (SCBA) may be required if cylinders rupture or release under fire conditions.\nACCIDENTAL RELEASE MEASURES\nSafeguards (Personnel) - NOTE-. Review FIRE FIGHTING MEASURES and HANDLING (PERSONNEL) sections before proceeding with clean-up. Use appropriate PERSONAL PROTECTIVE EQUIPMENT during clean-up.\nAccidental Release Measures: Ventilate area, especially low or enclosed places where heavy vapors might collect. Remove open flames. Use self-contained breathing apparatus (SCBA) if large spill or leak occurs. Evacuate area. Comply with Federal, State and local regulations on reporting releases.\nPotential Health Effects - Inhalation of high concentrations of vapor is harmful and may cause heart irregularities, unconsciousness or death. Intentional misuse or deliberate inhalation may cause death without warning. Vapor reduces oxygen available for breathing and is heavier than air. Liquid contact can cause frostbite.\nHuman Health Effects - Contact with the liquid may cause frostbite. Overexposure by inhalation may include nonspecific discomfort, such as nausea, headache, or weakness, or temporary nervous system depression with anesthetic effects such as dizziness, headache, confusion, incoordination, and loss of consciousness. Higher exposures may lead to temporary alteration of the heart's electrical activity with irregular pulse, palpitations, or inadequate circulation. Fatality may occur from gross overexposure.\nIndividuals with preexisting diseases of the central nervous or cardiovascular system may have increased susceptibility to the toxicity of excessive exposures.\nCarcinogenicity Information - None of the components present in this material at concentrations equal to or greater than 0. 1 % are listed by IARC, NTP, OSHA or ACGIH as a carcinogen.\nInhalation - If high concentrations are inhaled, immediately remove to fresh air. Keep person calm. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Call a physician.\nSkin Contact - In cases of contact, immediately flush skin with plenty of water for at least 15 minutes. Remove contaminated clothing and shoes. Call a physician. Treat for frostbite if necessary by gently warming affected area. Wash contaminated clothing before reuse.\nEye Contact - In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Call a physician.\nIngestion - Ingestion is not considered a potential route of exposure.\nNotes to Physicians - Because of possible disturbances of cardiac rhythm, catecholamine drugs, such as epinephrine, should be used with special caution only in situations of emergency life support.", "domain": "chemistry", "round": 3} +{"url": "https://mavro-int.shop/en/floorguard", "date": "2023-11-29T03:15:44Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100047.66/warc/CC-MAIN-20231129010302-20231129040302-00639.warc.gz", "language_score": 0.7784322500228882, "token_count": 368, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__251550861", "lang": "en", "text": "Floorguard is an effective water borne impregnating agent based on silane/siloxane technology.\nFloorguard penetrates deep within the surface and makes floors long-lasting water repellent.\nFloorguard does not seal the surface and therefore stays100% vapor permeable.\nFloorguard has excellent UV- and alkali-resistance.\nFloorguard is suitable for making mineral floors water-repellent, such as concrete, tiles and pavers.\n• Strong water-repellent properties\n• 100% vapor permeable\n• High penetration ability\n• Reduces dirt-adhesion\n• High durability\n1, 10 and 25 L.\n1. Ensure that the surface is completely dry.\n2. Apply Floorguard undiluted on the surface with a low pressure spray, roller or through the flow method. If necessary, apply a second layer wet-on-wet up to the point of complete saturation.\n3. Remove any excess material immediately with a lint-free cloth.\nAmbient temperature: maximum 30°C, minimum 10°C\nSubstrate temperature: maximum 30°C, minimum 10°C\nRelative humidity: max. 95% and 3°C above dew point\nWater repellent: After 2 hours\nDry: After 4 hours\nConsumption is 1-2 m2/L. Consumption is influenced by the absorbance and porosity of the surface.\nSTORAGE AND STABILITY\nCan be kept for at least 12 months in original unopened packaging.\nStore in a cool, frost-free place.\nAvoid eye contact, wear safety goggles. If in doubt, always consult the safety data sheet or our R&D department.", "domain": "chemistry", "round": 3} +{"url": "https://www.reportsandmarkets.com/reports/global-two-wheeler-catalytic-converter-market-insights-forecast-to-2025", "date": "2019-09-15T06:51:17Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-39/segments/1568514570740.10/warc/CC-MAIN-20190915052433-20190915074433-00482.warc.gz", "language_score": 0.9165018200874329, "token_count": 1015, "dump": "CC-MAIN-2019-39", "global_id": "webtext-fineweb__CC-MAIN-2019-39__0__169198195", "lang": "en", "text": "A catalytic converter is an exhaust emission control device that converts toxic gases and pollutants in exhaust gas from an internal combustion engine into less-toxic pollutants by catalyzing a redox reaction (an oxidation and a reduction reaction). Catalytic converters are usually used with internal combustion engines fueled by either gasoline or diesel—including lean-burn engines as well as kerosene heaters and stoves.\nThe rising strict emission norms for two-wheelers is one of the primary drivers for market growth. The increasing levels of vehicular emissions is inducing the governments of developing countries such as India and China to raise the stringency levels of two-wheeler emission norms. This, in turn, is foreseen to drive the requirement for catalytic converters. As a result, two-wheelers will be equipped with enhanced substrates to adhere to the proposed emission standards. Moreover, these additions of substrates and other emission control kits are likely to increase the price of two-wheelers over the next four years. Furthermore, with the government of India elevating its emission standards, the two-wheeler market in the country is expected to see a bigger penetration of fuel-injected vehicles.\nAPAC led the two-wheeler catalytic converter market during 2017 and is anticipated to continue the dominion during the forecast period. The increasing sales of two-wheelers, rising levels of traffic congestion, rising fuel rates, and an economical price tag, drives the growth of the two-wheeler market, which in turn, propelling market growth.\nGlobal Two-Wheeler Catalytic Converter market size will reach xx million US$ by 2025, from xx million US$ in 2018, at a CAGR of xx% during the forecast period. In this study, 2018 has been considered as the base year and 2019-2025 as the forecast period to estimate the market size for Two-Wheeler Catalytic Converter.\nThis industry study presents the global Two-Wheeler Catalytic Converter market size, historical breakdown data (2014-2019) and forecast (2019-2025). The Two-Wheeler Catalytic Converter production, revenue and market share by manufacturers, key regions and type;\nThe consumption of Two-Wheeler Catalytic Converter in volume terms are also provided for major countries (or regions), and for each application and product at the global level. Market share, growth rate, and competitive factors are also evaluated for market leaders Continental Emitec, Varroc Group, etc.\nThe following manufacturers are covered in this report:\nMunjal Auto Industries\nTwo-Wheeler Catalytic Converter Breakdown Data by Type\nSelective Catalytic Reduction (SCR)\nLean NOx Catalysts (LNC)\nLean NOx Trap (LNT)\nTwo-Wheeler Catalytic Converter Breakdown Data by Application\nTwo-Wheeler Catalytic Converter Production by Region\nTwo-Wheeler Catalytic Converter Consumption by Region\nRest of Europe\nCentral & South America\nRest of South America\nMiddle East & Africa\nRest of Middle East & Africa\nThe study objectives are:\nTo analyze and research the global Two-Wheeler Catalytic Converter status and future forecast，involving, production, revenue, consumption, historical and forecast.\nTo present the key Two-Wheeler Catalytic Converter manufacturers, production, revenue, market share, SWOT analysis and development plans in next few years.\nTo segment the breakdown data by regions, type, manufacturers and applications.\nTo analyze the global and key regions market potential and advantage, opportunity and challenge, restraints and risks.\nTo identify significant trends, drivers, influence factors in global and regions.\nTo strategically analyze each submarket with respect to individual growth trend and their contribution to the market.\nTo analyze competitive developments such as expansions, agreements, new product launches, and acquisitions in the market.\nIn this study, the years considered to estimate the market size of Two-Wheeler Catalytic Converter :\nHistory Year: 2014 - 2018\nBase Year: 2018\nEstimated Year: 2019\nForecast Year: 2019 - 2025\nThis report includes the estimation of market size for value (million USD) and volume (K Units). Both top-down and bottom-up approaches have been used to estimate and validate the market size of Two-Wheeler Catalytic Converter market, to estimate the size of various other dependent submarkets in the overall market. Key players in the market have been identified through secondary research, and their market shares have been determined through primary and secondary research. All percentage shares, splits, and breakdowns have been determined using secondary sources and verified primary sources.\nFor the data information by region, company, type and application, 2018 is considered as the base year. Whenever data information was unavailable for the base year, the prior year has been considered.", "domain": "chemistry", "round": 3} +{"url": "https://dalriadatx.com/articles/small-molecule-highlights-02-november-2022/", "date": "2023-10-05T02:31:04Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233511717.69/warc/CC-MAIN-20231005012006-20231005042006-00674.warc.gz", "language_score": 0.8866603374481201, "token_count": 1913, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__45872746", "lang": "en", "text": "Today’s post features eight (8) new molecules published this month that span a diverse list of drug targets: FFARs, CDK, SARS-CoV-Mpro, CatL, ALK, cMET, DGAT2, CaMKIIα, etc.\nThese molecules (and their associated research articles) profile several useful drug design strategies, including macrocyclization, dual-mode inhibition mechanisms, covalency, and the use of ligand-based pharmacophore models during HitID campaigns.\nThis blog was created to highlight progress in target-oriented drug discovery and new potential therapeutic opportunities.\nCompound 83: First-in-class dual-acting allosteric modulator of free fatty acid receptors (FFAR1/4) based on a 1,3,5-triazine-2-amine core-scaffold. FFARs (as GPCRs) have been implicated in various metabolic and inflammatory disorders (e.g. type-2 diabetes mellitus, T2DM). Biochemical potencies against FFAR1, and FFAR2 reported as IC50 = 1, 2 nM, respectively (representing an improvement relative to reference compound TAK-875). Metabolic instability (Liver S9 T1/2 = 1.9 mins) is suggested to stem from triazine-core degradation mechanism, with authors citing the need for further studies.\nCompound 42: Computer-aided drug design (CADD) via a large virtual library (N > 200K), pharmacophore models, and receptor-ligand docking experiments, identified a hit (compound 8) with a measurable inhibitory profile against cyclin-dependent kinases 6 (CDK6), IC50 = 3.7 μM. Medicinal chemistry efforts, ultimately generated compound 42, a CDK4/6 inhibitor (IC50 = 10/16 nM, ~200x improvement). In vivo pharmacokinetic studies revealed; F (%)o. (rats) = 43%, T1/2 = 3.5 hr, along with in vivo efficacy in a Balb/C MCF-7 (breast cancer) xenograft mouse model (100-150 mg/kg).\nSM141: Peptide-based dual inhibitor of the SARS-CoV2 Main protease (MPro) and Cathepsin L (CatL), with a reported IC50 of 900 nM, and 60 nM, respectively. Covalent mechanism of action against MPro, targeting active site Cys145 via acrylate electrophile. Selectivity was highlighted with minimal inhibition of related viral proteases (e.g. papain-like protease, PLPro), as well as cathepsin B (CatB) (both IC50 > 50 μM). Co-crystal resolved with MPro (PDB 7MB0). Cellular anti-viral activity observed in A549-hACE2 cells (IC50 = 8.2 nM), with intranasal (NAS) administration improving survival in K18-ACE2 transgenic mice (infected with SARS-CoV2).\nD6808: Molecular hybridization and macrocyclization strategies were used to identify D6808, a macrocyclic cMET kinase inhibitor (IC50 = 2.9 nM), with efficacy in MET-amplified Hs746T gastric cancer cells (IC50 = 0.7 nM). Broad cytotoxicity was observed in resistance-relevant Ba/F3-Tpr-Met cells (F1200L, M1250T, H1094Y, F1200I, L1195V), with IC50 values of 4.2, 3.2, 1.0, 39.0, and 33.4 nM, respectively. Macrocycle was generated via pentafluorophenyl diphenylphosphinate (FDPP) mediated amide-bond formation. Co-crystal with cMET resolved (PDB 8GVJ), and kinome selectivity was observed against a panel of 373 kinases (with observed off targets including Axl, and TrkA-C).\nPF-06865571: A first-in-class systemically acting diacylglycerol acyltransferase (DGAT2) inhibitor, developed for use in non-alcoholic steatohepatitis (with liver fibrosis). Medicinal chemistry efforts were focused on mitigating CYP450-mediated safety risks of previous analogs, along with reducing apparent rates of hepatic clearance. In an enzymatic activity assay, PF-06865571 was reported to have an IC50 of 17.2 nM. Physicochemical analyses of TPSA, and LogD4 found values of 108 Å2, 1.9, respectively. Pharmacokinetic studies found oral bioavailability F (%)rats of 31%, with a reduced apparent HHEP CLint of 3.9 μL/mins/106 cells (relative to previous analog). In vivo efficacy was observed via the reduction of plasma/hepatic triglycerides (TG) levels in relevant rat models (0.3-90 mg/kg, p.o.).\nPH-HTBA: Ca2+/calmodulin-dependent kinase II-alpha (CaMKIIα) is a Ser/Thr-specific kinase, with important CNS roles in memory/learning, Ca2+ homeostasis/re-uptake, Cl– transport, and T-cell activation. In recent years, it has been cited as an emerging drug target for several neurodegenerative disorders. Given CaMKIIα small molecule inhibitors generally suffer from poor sub-type selectivity, and poor brain penetrance, Ph-HTBA represents a novel, brain-permeable fragment (IC50 = 78 nM), CaMKIIα hub-domain KD (SPR) = 757 nM, with observable thermal stabilization, ΔTm (DSF) = +19.02 oC (at >100 μM). Pharmacokinetic analyses revealed an interesting species variance in hepatic clearance between mouse/human in vitro hepatocyte models, CLint = 65/8.6 μL/mins/106 cells.\nCRBN (FLT3)-8: FMS-like tyrosine kinase 3 (FLT3) with an internal tandem duplication (ITD), generating FLT3-ITD, is the most common driver mutation in AML (incidence in ~25% of all patients). While current FLT3i are efficacious, resistance due to FLT3 reactivation is common in the clinic. One novel approach towards FLT3-ITD inhibition involves the use of proteolysis targeting chimeras (PROTACs), a special class of heterobifunctional small molecules, which are used for intracellular targeted protein degradation (TPD). CRBN(FLT3)-8 is a Gilteritinib (clinical FLT3i) based PROTAC, with a CRBN E3 ligase, and a PEG2 linker. Downregulation of FLT3 reported in both MV4-11/MOLM-14 cells, which was supressed in presence of UPSi (suggesting a UPS-dependent MOA). Relevant cell activity was reported in FLT3-ITD mutant AML lines (MV4-11/MOLM-14), IC50 = 0.9/2.8 nM.\nCompound 10K: Anaplastic lymphoma kinase (ALK) represents a validated drug target for non-small cell lung cancer (NSCLC). Compound 10K is reported as the first boronic-acid containing ALK inhibitor, with an observed ALKL1196M IC50 of 8.4 nM. Computational docking models, suggest the unique boronate-motif forms a H-bond with key Asn or Asp residues. Cytotoxicity was observed in NCI-H2228 cells (IC50 = 520 nM), with in vivo efficacy in a relevant lung cancer xenograft model in nude mice (50 mg/kg, i.g., tumor growth inhibitor rate, TGI = 52%)", "domain": "chemistry", "round": 3} +{"url": "http://www.biopaqc.com/2018/12/14/the-xanthophyll-cycle-xc-that-involves-violaxanthin-de-epoxidase-vde-as-well/", "date": "2023-09-30T10:21:10Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233510671.0/warc/CC-MAIN-20230930082033-20230930112033-00528.warc.gz", "language_score": 0.9329392313957214, "token_count": 1180, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__228451809", "lang": "en", "text": "The xanthophyll cycle (Xc), that involves violaxanthin de-epoxidase (VDE) as well as the zeaxanthin epoxidase (ZEP), is among the most rapid and efficient responses of plant and algae to high irradiance. electron transportation and chlororespiration) could preserve VDE activity. Furthermore, accumulations of Ax and Zx reduced considerably when SA, DCMU, or DBMIB as well as an inhibitor of chlororespiration (i.e., propyl gallate (PG)) had been put on sp. This result shows that chlororespiration not merely participates within the build-up of the required pH, but that in addition, it possibly affects VDE activity indirectly by diminishing the air level within the chloroplast. Intro Light is vital for photosynthesis, however it also could be potentially bad for plants. To avoid extra absorption of light energy and consequent oxidative harm to the photosynthetic equipment, higher plants & most algae developed various photoprotection systems. Probably one of the most quick and efficient of the mechanisms may be the xanthophyll routine (Xc) , . Its procedure involves two crucial enzymes: Violaxanthin de-epoxidase (VDE) catalyzes the transformation of violaxanthin (Vx) to zeaxanthin (Zx) via antheraxanthin (Ax), and Zx epoxidase (ZEP) catalyzes the invert response, from Zx to Vx via Ax , , . Even though enzyme VDE continues to be purified in higher vegetation and comprehensively looked into in vitro , , some queries still remain. Initial, it is popular that VDE and ZEP function antagonistically in vivo; therefore, study from the elements that regulate the experience of VDE in vivo is usually hampered by the current presence of ZEP. Although ZEP mutants have already been obtained in a few higher vegetation , , and green algae , these mutants aren’t very ideal for learning VDE in vivo due to scarcity of Vx in LHCII . Therefore, inhibiting ZEP using inhibitors in crazy type organisms could be an alternative way for characterizing VDE 1444832-51-2 IC50 activity in vivo. Second, though it is well known that high light strength can activate VDE to convert Vx to Zx via Ax, it really is unclear whether VDE continues to be 1444832-51-2 IC50 energetic under low light or dark circumstances when there is absolutely no significant deposition of Ax 1444832-51-2 IC50 and Zx, and when so, the way the required pH over the thylakoid membrane for the experience of VDE is made. sp. (Ulvales, Chlorophyta) is really a macro-alga developing in the intertidal area, where maximal irradiances frequently become greater than 1000 mol m?2s?1. Hence, efficient photoprotection systems should be essential for its success. Meanwhile, sp. Mmp13 comprises two levels of cells, which might be crucial for the effective infiltration of varied inhibitors in to the thalli. Herein, sp. was utilized to research the operation from the Xc under low light strength in vivo in the current presence of salicylaldoxime (SA), which inhibits the catalytic capability of ZEP. We suggest that both VDE and ZEP are completely working in sp. under low light and dark circumstances, and, within the last mentioned case, the mandatory pH could be constructed by chlororespiration-mediated electron transportation. Materials and Strategies Algae examples sp. (Ulvales, Chlorophyta) was gathered from Zhanshan, Qingdao (3605N, 12018E), China. This area isn’t privately-owned or secured at all, thus no particular permissions had been required, as well as the field research didn’t involve endangered or secured types. The thalli had been rinsed with sterilized seawater to eliminate fine sand and epiphytes, and had been cultured at 15C2C in seawater with lighting at about 50 mol m?2s?1 given white fluorescent light before the tests. Treatment with metabolic inhibitors SA at your final focus of 5 mM was utilized to inhibit the experience of ZEP . This focus does not impact the actions of plastocyanin and PSI . Dithiothreitol (DTT), which inhibits VDE by reducing the disulfide bridge within VDE, was utilized at your final focus of 3 mM . To judge the consequences of pH around the SA-induced accumulations of Zx and Ax, carbonyl cyanide p-trifluoromethoxyphenylhydrazone (FCCP) at your final focus of 10 M was utilized to collapse the trans-thylakoid membrane proton gradient . The electron transportation systems across the thylakoid membrane had been inhibited by 10 M of 3-(3, 4-dichlorophenyl)-1, 1-dimethylurea (DCMU) around the PSII site , 10 M of dibromothymoquinone (DBMIB) around the cytochrome b6f complicated site , or 1 mM of propyl gallate (PG) around 1444832-51-2 IC50 the plastid terminal oxidase (PTOX) site . All inhibitors had been ready as 1000 share solutions.", "domain": "chemistry", "round": 3} +{"url": "https://a-c-s.confex.com/a-c-s/2007am/techprogram/P35078.HTM", "date": "2022-11-30T19:30:20Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-49/segments/1669446710771.39/warc/CC-MAIN-20221130192708-20221130222708-00571.warc.gz", "language_score": 0.891445517539978, "token_count": 370, "dump": "CC-MAIN-2022-49", "global_id": "webtext-fineweb__CC-MAIN-2022-49__0__214599009", "lang": "en", "text": "Effects of Waterlogging on Mitochondrial Oxidative Injury and Manganese Superoxide Dismutase in Roots of Kentucky Bluegrass.\nYiwei Jiang1, Kehua Wang2, and Jeffrey Volenec1. (1) Agronomy Dept, Purdue University-Agronomy Dept., Purdue University, 915 W. State Street, West Lafayette, IN 47907, (2) Agronomy Dept., Purdue University, 915 W. State Street, West Lafayette, IN 47907\nOxidative injury occurs in root mitochondria in response to waterlogging. The objective of this project was to investigate effects of waterlogging on mitochondrial oxidative injury and mitochondrial manganese superoxide dismutase (Mn-SOD) in roots of Kentucky bluegrass (Poa pratensis L.). Two cultivars of Moonlight (waterlogging tolerant) and Kenblue (waterlogging sensitive) were subjected to 1, 3 and 7 d of waterlogging. Mitochondrial superoxide and hydrogen peroxide concentrations did not change for both cultivars under waterlogging conditions. At 7 d of waterlogging, mitochondrial lipid peroxidation remained unchanged in Moonlight but increased in Kenblue, and mitochondrial total SOD activity increased in both cultivars. Immunoblots showed an increased intensity of mitochondrial Mn-SOD polypeptide (25 kDa) at 7 d of waterlogging, particularly in Kenblue, while RT-PCR indicated that the transcript abundance for mitochondrial Mn-SOD decreased in both cultivars. The results suggested that the tolerant grass had less oxidative injury than the intolerant grass in response to the extended waterlogging condition, and regulation of mitochondrial Mn-SOD activity may be occurring at several levels in the roots of Kentucky bluegrass.", "domain": "chemistry", "round": 3} +{"url": "https://saemobilus.sae.org/content/940819/", "date": "2022-06-29T02:54:49Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-27/segments/1656103620968.33/warc/CC-MAIN-20220629024217-20220629054217-00536.warc.gz", "language_score": 0.8057851195335388, "token_count": 1414, "dump": "CC-MAIN-2022-27", "global_id": "webtext-fineweb__CC-MAIN-2022-27__0__239101754", "lang": "en", "text": "This content is not included in your SAE MOBILUS subscription, or you are not logged in.\nPrediction of Viscosity-Shear Properties for VI Improved Crankcase Oils\nISSN: 0148-7191, e-ISSN: 2688-3627\nPublished March 01, 1994 by SAE International in United States\nAnnotation ability available\nThis study evaluates the shear-thinning effects of a commercial Viscosity Index (VI) improver in a variety of mineral oil base stocks to produce a series of viscosity grades from 0W-20 to 20W-50. All of these fluids also include a DI package in addition to an olefin copolymer VI improver and base oil. The Penn State high shear capillary viscometer was used to collect the primary data at shear rates of up to 106 s-1 and at 10 to 177°C. Data are fitted to a double truncated power law model to determine the incipient non-Newtonian shear rate Υ̇1, the power law index n, and the incipient second Newtonian shear rate Υ̇2. These parameters are found to be smooth functions of temperature and polymer concentration in the different base stocks. Using the data obtained from OW-20, 10W-30, and 20W-50 SAE grade formulations, these parameters (Υ̇1, Υ̇2 and n) are correlated as functions of temperature, polymer concentration, and a viscosity temperature property of the base oil.\nThese correlations were then used to predict Υ̇1, Υ̇2 and n for 10 additional multigrade lubricants formulated with the same VI additive. These three parameters and the Newtonian viscosity of these oils at 150°C predicted high temperature-high shear values at 104, 105, and 106 s-1 with the same precision as direct measurement with the Penn State high temperature, high shear viscometer. Consequently, this paper presents a method of predicting blend properties from a simple calibration system for blends of a single VI polymer in a relatively homogeneous set of base oils.\nCitationKlaus, E., Duda, J., and Bala, V., \"Prediction of Viscosity-Shear Properties for VI Improved Crankcase Oils,\" SAE Technical Paper 940819, 1994, https://doi.org/10.4271/940819.\nSAE 1994 Transactions: Journal of Fuels and Lubricants\nNumber: V103-4; Published: 1995-09-01\nNumber: V103-4; Published: 1995-09-01\n- Stewart, R. M. Selby, T. W. “The Relationship Between Oil Viscosity and Engine Performance -- A Literature Search,” SAE Paper No. 770372 SAE 1977\n- Klaus, E. E. Shah, P. Krishnamachar, V. “Development and Use of the Microoxidation Test with Crankcase Oils,” Proceedings of the Conference on Measurements and Standards for Recycled Oil 155 168 1982\n- Perez, J. M. Kelly, F. A. Klaus, E. E. Bogrodia, V. “Development and Use of the PSU Microoxidation Test for Diesel Engine Oils,” SAE Paper No. 872028 1987\n- McMillan, M. L. Opening Address at SAE Open Forum Detriot, Michigan Feb. 26 1976\n- Workshop Summary, Workshop I High Shear High Temperature Viscometry The 1981 International Conference on the Viscometry of Automotive Lubricants 1981\n- ASTM ‘The Relationship between High Temperature Oil Rheology and Engine Operation - A Status Report’ ASTM Philadelphia 1984\n- Balasubramaniam (Bala), V. “High Shear Rheology of Multigrade Lubricants,” The Pennsylvania State University 1992\n- Klaus, E. E. Fenske M. R. “The Use of ASTM Slope for Predicting Viscosities,” ASTM Bulletin No. 215 87 94 1956\n- Lee, F. L. “Measurement and Analysis of High Shear Viscosities of Polymer-Containing Lubricants,” The Pennsylvania State University 1985\n- Lin, S. C. “Rheological Studies of Polymer Solutions at High Shear Rates,” The Pennsylvania State University 1988\n- Klaus, E. E. Angeloni, F. M. Fenske, M. R. “Development and Application of the PRL Single-Pass Capillary Viscometer,” ASTM Sp. Tech. Publication 28 48 1961\n- Melodick, T. Thesis M.S. “High Shear Behavior of Polymer Containing Lubricants,” The Pennsylvania State University 1988\n- Duda, J. L. Klaus, E. E. Lin, S. L. Lee, F. L. “High Shear Viscosity Studies of Polymer Containing Lubricants,” Proceedings Leeds-Lyons Conference Leeds, England 1986\n- Duda, J. L. Klaus, E. E. Lin, S. C. “Capillary Viscometry Study od non-Newtonian Fluids: Influence of Viscous Heating,” Ind. Eng. Chem. Res. 27 2 352 361 1988\n- Wu, C. S. Melodick, T. Lin, S. C. Duda, J. L. Klaus, E. E. “The Viscous Behavior of Polymer-Modified Oils Over a Broad Range of Temperature and Shear Rate,” J. of Tribology 112 417 425 1990\n- Klaus, E. E. Duda, J. L. Bala, V. “Prediction of High Temperature Viscosities of Polymer Solutions up to 107 s-1 Shear Rates,” SAE Paper No. 912411 1991\n- Bala, V. Klaus, E. E. Duda, J. L. Palekar V. “Extension of the Temperature and Shear Rate Range for Polymer Containing Lubricants Using the Cannon HTHS Capillary Viscometer,”\n- Venerus, D. Klaus, E. E. Duda, J. L. “Low-Temperature Rheological Studies of Hydrocarbon Base Lubricants,” SAE Paper No. 872048 1987", "domain": "chemistry", "round": 3} +{"url": "http://abpapernnex.hyve.me/thesis-anticancer-activity-plants.html", "date": "2018-06-19T14:44:19Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-26/segments/1529267863043.35/warc/CC-MAIN-20180619134548-20180619154548-00455.warc.gz", "language_score": 0.8425344228744507, "token_count": 520, "dump": "CC-MAIN-2018-26", "global_id": "webtext-fineweb__CC-MAIN-2018-26__0__224753560", "lang": "en", "text": "Thesis anticancer activity plants\nTo anticancer activity in conclusion this article provides the knowledge about anticancer medicinal plants of foreign origin phd thesis j n k v v jabalpur. Anticancer activity of medicinal plants phd thesis - top ten phd thesis in anticancer activity of medicinal plants. Home thesis anticancer activity plants subscribe to this rss feed thesis anticancer activity plants. 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Thesis on anticancer activity of plant extracts the authenticity of our custom essay writing and confidentiality of all information are guaranteed.\nLe bio sacré vous propose une gamme de produits alimentaires et cosmétiques bio & naturels au meilleur prix. Antidiabetic, anticancer activity of medicinal plants phd thesis anticancer activity of investigation of bioactive compounds with anti-cancer potential in.\nBest resume writing services in new york city 5k anticancer activity phd thesis graduate admission essay for low gpa write a research paper fast. Thesis anticancer activity plants professional essay and resume writing services offering expertise in writing cvs, resumes and cover letters customized by the. Thesis master com anticancer activity phd thesis help with write college us monster phd dissertation on e learningthesis anticancer activity plants.\n- A thesis submitted to 21 screening methods of anticancer activity: 22 anticancer medicinal plants of india 23 references 3 material and methods.\n- Thesis anticancer activity plants meeting the deadline is one of the main requirements for any paper — so our essay writing service guarantees that you get your.\nHerbal and medicinal plants molecules towards anticancer activity by using phd thesis j n k v v jabalpur, 2003. A study on the effect of some plant extracts on certain malignant cell plant extracts with potential anticancer activity of hela cells in response to plant.", "domain": "chemistry", "round": 3} +{"url": "http://41.newsoftheworld.top/bonding-and-chemical-formulas-worksheet-answers/", "date": "2020-08-13T00:00:47Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-34/segments/1596439738950.31/warc/CC-MAIN-20200812225607-20200813015607-00503.warc.gz", "language_score": 0.878492534160614, "token_count": 1914, "dump": "CC-MAIN-2020-34", "global_id": "webtext-fineweb__CC-MAIN-2020-34__0__114983983", "lang": "en", "text": "Table of Contents :\nTop Suggestions Bonding And Chemical Formulas Worksheet Answers :\nBonding And Chemical Formulas Worksheet Answers Bitesize daily has ended but the episodes are still available to watch on bbc iplayer each programme includes a combination of core subjects like english maths and science as well as other.\nBonding And Chemical Formulas Worksheet Answers\nChemical Bonding Worksheet Chemistry Libretexts\nBond Classifications Chemical Bonds Are The Attractive Forces That Hold Atoms Together In The Form Of Compounds A Chemical Bond Is Formed When Electrons Are Shared Between Two Atoms There Are Three Types Of Bonds Covalent Bonds Polar Covalent Bonds And Ionic Bonds The Simplest Example Of Bonding Is Demonstrated By The H 2 Molecule We Can\nChemical Bonding Worksheet Chemistry Libretexts\nChemical Bonding Worksheet Last Updated Save As Page Id Contributed By Richard Banks Professor Emeritus Chemistry At Boise State No Headers Back To Top Building Atoms With Quantum Leaps 1 Worksheet Electron Dot Formulas Worksheet Recommended Articles There Are No Recommended Articles Article Type Section Or Page Author Richard Banks Show Toc No On Page Tags Banks\nChemical Bonding Worksheets Lesson Worksheets\nChemical Bonding Displaying All Worksheets Related To Chemical Bonding Worksheets Are Ionic Bonding Work 1 Chemical Bonding Chemical Bonding Chemical Bonding 6 Chemical Bonding Chemical Bonding Chem Work 3 Ionic And Covalent Bonding Model 1 Covalent Bonding Work Click On Pop Out Icon Or Print Icon To Worksheet To Print Or Download\nBonding And Chemical Formulas Answers\nBonding And Chemical Formulas Worksheet Answers Wider Awake Realized That And Modules That Offer To Be A Very And Immediately Notifies Business More Chemical Names And Formulas Section 6 An Ite Or Ate Ending Means There Is A Ion That Includes Oxygen In The Formula Unit 2 Chemical Names Formulas Learning Targets By The End Of The Unit A Student In This Course Should Be Able\nChapter 7 Bonding And Chemical Formulas Worksheet Answers\nChapter 7 Chemical Formulas Bonding Study Guide By Kellymandella Includes 74 Questions Covering Vocabulary Terms And More Quizlet Flashcards Activities And Games Help You Improve Your Grades 7 Chemical Formulas And Chemical Compounds Chapter 7 Review Chemical Formulas And Chemical Compounds Section 4 Short Answer Answer The Following Questions In The Space Provided 1 Write EmpiricalChemical Bonding Activity Free Chemistry Materials\nChemistry Chemical Bonding Activity Introduction When Atoms Bond Together To Form Ionic Compounds They Will Not Combine With Just Any Other Atom For Example Two Atoms That Will Never Form An Ionic Bond Are A Sodium Atom Na And A Potassium Atom K This Is Because Both Na1 And K1 Are Cations Or Positively Charged Ions In Order For Two Atoms To Form An Ionic Bond One Must Be ATypes Of Chemical Bonds Worksheet Answers Mychaume\nChemical Bonding Worksheet Answers Types Chemical Bonds From Types Of Chemical Bonds Worksheet Answers Source Ngosaveh Types Of Chemical Bonding Worksheet Answers Types Chemical Bonds From Types Of Chemical Bonds Worksheet AnswersChemical Names And Formulas Printable Worksheets\nChemical Formulas To Chemical Names Answer Key In Order To Complete These Worksheets You May Wish To Review The Rules For Naming Ionic Compounds And Covalent Compounds Other Printable Chemistry Worksheets Are Also Available Such As Chemistry Element Word Search Puzzles\n7 Chemical Formulas And Chemical Compounds\nChemical Formulas And Chemical Compounds Section 1 Short Answer Answer The Following Questions In The Space Provided 1 C In A Stock System Name Such As Iron Iii Sulfate The Roman Numeral Tells Us A How Many Atoms Of Fe Are In One Formula Unit B How Many Sulfate Ions Can Be Attached To The Iron Atom C The Charge On Each Fe Ion\nChemical Bonding Chemical Formula\nAn Ionic Bond Is Defined When The Electronegative Values Between The Two Atoms Is Greater Than 1 7 Chemical Bonding Between Molecules Molecules Are Discrete Particles That Exist As Single Unitse Atoms Within A Molecule Are Joined Together By Strong Covalent Bondse Molecules Are Joined Together In The Solid And Liquid States By Weak Intermolecular Forces\nBonding And Chemical Formulas Worksheet Answers. The worksheet is an assortment of 4 intriguing pursuits that will enhance your kid's knowledge and abilities. The worksheets are offered in developmentally appropriate versions for kids of different ages. Adding and subtracting integers worksheets in many ranges including a number of choices for parentheses use.\nYou can begin with the uppercase cursives and after that move forward with the lowercase cursives. Handwriting for kids will also be rather simple to develop in such a fashion. If you're an adult and wish to increase your handwriting, it can be accomplished. As a result, in the event that you really wish to enhance handwriting of your kid, hurry to explore the advantages of an intelligent learning tool now!\nConsider how you wish to compose your private faith statement. Sometimes letters have to be adjusted to fit in a particular space. When a letter does not have any verticals like a capital A or V, the very first diagonal stroke is regarded as the stem. The connected and slanted letters will be quite simple to form once the many shapes re learnt well. Even something as easy as guessing the beginning letter of long words can assist your child improve his phonics abilities. Bonding And Chemical Formulas Worksheet Answers.\nThere isn't anything like a superb story, and nothing like being the person who started a renowned urban legend. Deciding upon the ideal approach route Cursive writing is basically joined-up handwriting. Practice reading by yourself as often as possible.\nResearch urban legends to obtain a concept of what's out there prior to making a new one. You are still not sure the radicals have the proper idea. Naturally, you won't use the majority of your ideas. If you've got an idea for a tool please inform us. That means you can begin right where you are no matter how little you might feel you've got to give. You are also quite suspicious of any revolutionary shift. In earlier times you've stated that the move of independence may be too early.\nEach lesson in handwriting should start on a fresh new page, so the little one becomes enough room to practice. Every handwriting lesson should begin with the alphabets. Handwriting learning is just one of the most important learning needs of a kid. Learning how to read isn't just challenging, but fun too.\nThe use of grids The use of grids is vital in earning your child learn to Improve handwriting. Also, bear in mind that maybe your very first try at brainstorming may not bring anything relevant, but don't stop trying. Once you are able to work, you might be surprised how much you get done. Take into consideration how you feel about yourself. Getting able to modify the tracking helps fit more letters in a little space or spread out letters if they're too tight. Perhaps you must enlist the aid of another man to encourage or help you keep focused.\nBonding And Chemical Formulas Worksheet Answers. Try to remember, you always have to care for your child with amazing care, compassion and affection to be able to help him learn. You may also ask your kid's teacher for extra worksheets. Your son or daughter is not going to just learn a different sort of font but in addition learn how to write elegantly because cursive writing is quite beautiful to check out. As a result, if a kid is already suffering from ADHD his handwriting will definitely be affected. Accordingly, to be able to accomplish this, if children are taught to form different shapes in a suitable fashion, it is going to enable them to compose the letters in a really smooth and easy method. Although it can be cute every time a youngster says he runned on the playground, students want to understand how to use past tense so as to speak and write correctly. Let say, you would like to boost your son's or daughter's handwriting, it is but obvious that you want to give your son or daughter plenty of practice, as they say, practice makes perfect.\nWithout phonics skills, it's almost impossible, especially for kids, to learn how to read new words. Techniques to Handle Attention Issues It is extremely essential that should you discover your kid is inattentive to his learning especially when it has to do with reading and writing issues you must begin working on various ways and to improve it. Use a student's name in every sentence so there's a single sentence for each kid. Because he or she learns at his own rate, there is some variability in the age when a child is ready to learn to read. Teaching your kid to form the alphabets is quite a complicated practice.\nTags: #high school covalent bonding worksheet answer key#empirical formula worksheet answer key#worksheets for chemical bonding#ionic vs covalent bonds worksheet#drawing covalent bonds worksheet#naming molecular compounds worksheet answers#ionic and metallic bonding worksheet#chemistry chapter 7 worksheet answers#intro to bonding worksheet answers", "domain": "chemistry", "round": 3} +{"url": "https://www.gatewaypackaging.com.au/packaging/marking-identification/cleaners-degreasers-lubricants/wd-40/", "date": "2024-04-13T06:19:11Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712296816586.79/warc/CC-MAIN-20240413051941-20240413081941-00814.warc.gz", "language_score": 0.8902735114097595, "token_count": 318, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__29515480", "lang": "en", "text": "In the realm of industrial lubrication, look no further than our exceptional WD-40 Lubricant products. Crafted to excel in the most demanding environments, these specialized solutions redefine performance and efficiency for your industrial cleaning and maintenance requirements.\nFor those prioritizing sustainability and functionality, our WD-40 Refillable Spray Bottle is an intelligent choice. This adaptable container is specifically designed to accommodate WD-40 lubricant spray, providing a practical way to refill and reuse. By minimizing waste and ensuring constant access to lubrication, it aligns perfectly with industrial needs.\nWithin the bustling environments of workshops and warehouses, the WD-40 Lubricant in a 20-liter drum is a cornerstone asset. It addresses the challenges of rusted components, water displacement, and the establishment of protective barriers. This substantial bulk drum becomes a workhorse for heavy-duty applications, enhanced by its compatibility with refillable spray bottles for maximum operational ease.\nFor industrial professionals seeking the optimal equilibrium between potency and convenience, our WD-40 Lubricant Spray in a 4-liter drum strikes the perfect balance. It expertly loosens rusted mechanisms, displaces water, and creates robust protective barriers. With each carton containing four drums, you're equipped with a dependable supply, ensuring uninterrupted maintenance efforts.\nElevate your lubrication strategies with our high-performance WD-40 products, tailored specifically for industrial settings. Connect with our dedicated sales team today to explore the comprehensive range and find the perfect solution aligned with your unique industrial requirements.", "domain": "chemistry", "round": 3} +{"url": "https://iwaponline.com/wst/article-abstract/39/1/97/4864/Modeling-hydrolysis-processes-considering?redirectedFrom=fulltext", "date": "2021-10-26T02:28:17Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-43/segments/1634323587794.19/warc/CC-MAIN-20211026011138-20211026041138-00197.warc.gz", "language_score": 0.9032495617866516, "token_count": 334, "dump": "CC-MAIN-2021-43", "global_id": "webtext-fineweb__CC-MAIN-2021-43__0__224463103", "lang": "en", "text": "The process of hydrolysis of slowly biodegradable organics under different electron acceptor conditions has been pointed out as a weak part of Activated Sludge Model no. 2. Limited research input in this direction has led to lack of consensus and centered entire model uncertainties to this process. Here, we report consolidated results of our previous experimental studies on extracellular enzymatic hydrolysis. The main emphasis has been to understand general characteristics of extracellular hydrolytic enzymes in pure cultures and activated sludge. The experimental results suggest that the hydrolysis rates are not affected by the electron acceptor conditions for a single sludge steady state operated reactor. Since intracellular storage may influence correct interpretation of hydrolysis, it seems essential to evolve methods to study intracellular storage degradation and extracellular hydrolysis as two different processes. As the present wastewater characterization and model parameter estimation schemes do not consider storage aspects, this separation appears to be difficult. Hence, an experimental methodology is described to study hydrolysis and storage as two independent processes along with its limitations.\nModeling hydrolysis processes considering intracellular storage\nRajeev Goel, Takashi Mino, Hiroyasu Satoh, Tomonori Matsuo; Modeling hydrolysis processes considering intracellular storage. Water Sci Technol 1 January 1999; 39 (1): 97–105. doi: https://doi.org/10.2166/wst.1999.0022\nDownload citation file:\nImpact Factor 1.915\nCiteScore 3.3 • Q2\nFirst Decision in 30 days", "domain": "chemistry", "round": 3} +{"url": "http://clondrohidastro.com/index.php/lib/advances-in-protein-chemistry-8", "date": "2018-07-20T18:06:49Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-30/segments/1531676591719.4/warc/CC-MAIN-20180720174340-20180720194340-00484.warc.gz", "language_score": 0.8566235303878784, "token_count": 730, "dump": "CC-MAIN-2018-30", "global_id": "webtext-fineweb__CC-MAIN-2018-30__0__148383232", "lang": "en", "text": "By M L Anson; J T Edsall\nADVANCES IN PROTEIN CHEMISTRY VOL 8.\nRead or Download Advances in Protein Chemistry, 8 PDF\nSimilar botany books\nThis booklet presents up to date insurance of fossil vegetation from Precambrian existence to flowering vegetation, together with fungi and algae. It starts with a dialogue of geologic time, how organisms are preserved within the rock list, and the way organisms are studied and interpreted and takes the scholar via the entire proper makes use of and interpretations of fossil crops.\nHorticultural studies offers cutting-edge reports on subject matters in horticultural technology and expertise protecting either uncomplicated and utilized study. subject matters lined contain the horticulture of culmination, greens, nut vegetation, and ornamentals. those evaluation articles, written by means of global professionals, bridge the distance among the really expert researcher and the wider group of horticultural scientists and lecturers.\n- Studies Of Trees In Winter: A Description Of The Deciduous Trees Of Northeastern America\n- Enzyme catalysis and control\n- Progress in Botany / Fortschritte der Botanik: Morphology · Physiology · Genetics · Taxonomy · Geobotany / Morphologie · Physiologie · Genetik · Systematik · Geobotanik\n- Phytoplasma: Methods and Protocols\nExtra resources for Advances in Protein Chemistry, 8\nThis method is based on the opening of the lactame bond of the pyrrolidone nucleus by treatment of 2-pyrrolidone-5-carboxylic acid and its amide with hydrogen chloride-saturated ethanol. HzC- CaHsOH H i r C O h T 1 2 ----+ Ot! N ‘’ H HCI H2C-CHz i : Hi I:-CONHz C Z H00 ~ NHs, HCl For the preparation of I11 (diagram 5), t h e starting compound is ethyl I,-2-pyrrolidone-5-carboxylate (C,), prepared according t o Chiles and Noyes (118). It is converted to the corresponding hydrazide (CZ)and azide ((28).\nThe latter workers, in particular, described the production and purification of a biologically active substance, which they named polymyxin. At almost the same time, Ainsworth, Brown, and Brownlee (16) announced the discovery of the production of a new antibiotic called aerosporin, by B. aerosporus, a species closely related t o B. polymyxa. Later aerosporin was classified with the polymyxin group under the name polymyxin A. Actually, it appears that there are several polymyxins, each synthesized by different strains of B.\nE. Antibacterial and Toxic Activity. Crude preparations of licheniformin possess antibiotic activity (107) against a wide range of organisms. The licheniformins A and C are distinctly less active than the crude product, with respect to the acid-resistant microorganisms, whereas licheniformin B is distinctly more active. The three licheniformins, t o different degrees, provoke in mice severe renal lesions, which can lead to death. If one compares the toxicity of licheniformins with their antibiotic activity on 55 NATURALLY OCCUIZRING m:PTInEs TABLES (108) mg.", "domain": "chemistry", "round": 3} +{"url": "https://thundersaidenergy.com/downloads/landfill-gas-the-economics/", "date": "2024-04-13T02:36:36Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712296816535.76/warc/CC-MAIN-20240413021024-20240413051024-00001.warc.gz", "language_score": 0.9162400960922241, "token_count": 315, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__173287607", "lang": "en", "text": "The purpose of this data-file is to model the typical costs of producing raw landfill gas (a mixture of CH4, CO2 and other impurities) at a solid waste landfilling facility. Raw and unprocessed landfill gas can be economical to commercialize at a cost of $2-4/mcfe. Capex, opex and other costs of landfill gas are built up in the data-file.\nOur capex and opex cost build-ups for landfill gas are derived from EPA guidance and our gas evolution equations are derived from a line-by-line breakdown of landfill products (below). Note this is prior to gas cleaning and upgrading.\nWe estimate that a typical landfill facility may be able to capture and abate 70% of its methane leaks for a CO2-equivalent cost of $5/ton. Other landfill gas pathways get more complex and expensive.\nDetractors from nature-based carbon offsets argue that the CO2 captured by trees inevitably degrades and returns to the atmosphere, rendering reforestation useless. Historically, the IPCC assumed 50% of wood decomposed in landfills. But this was based on flawed lab-studies that started by grinding up “wood” into a fine dust. More recent data are tabulated in the data-file, from studies of wood in landfill sites. 80-95% of the carbon in wood remains after 40-100 years.\nThis model feeds into a deeper-dive research report, exploring the opportunities for landfill gas in the energy transition.", "domain": "chemistry", "round": 3} +{"url": "https://lubricantexpona.com/syn-tech-ltd-zero-migration-automotive-interior-lubricants/", "date": "2023-09-27T17:37:49Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233510319.87/warc/CC-MAIN-20230927171156-20230927201156-00163.warc.gz", "language_score": 0.8996831774711609, "token_count": 266, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__175073572", "lang": "en", "text": "Syn-tech Ltd.: Zero Migration Automotive Interior Lubricants\nFriday, 11 August 2023\nOil migration from a lubricant used on interior components can create staining of plastics and fabrics, contamination of electrical contacts and premature grease failure due to oil loss resulting in increased customer complaints, warranty work and the potential for recalls.\nOil migration can be induced by resin surface finish, temperature gradients and capillary forces. Syn-Tech Ltd’s automotive customers are constantly pushing the limits of electrical switches, interior compartment door assemblies and actuators by reducing material content to make them lighter in weight. Lubricants used in automotive cabins must exhibit no oil migration at high temperature without increasing efforts at low temperatures.\nSyn-Tech Ltd. has developed a full line of zero migration greases for plastic and metal actuators, hinges and slides. We also provide greases for the mechanical sections of high current, butt action window lift switches that prevent oil migration onto heat generating switch contacts. Advantages seen are enhanced visuals, improved smooth feel and extended component life while exhibiting low grease induced efforts at temperatures below -40°C and providing a robust lubricating film at temperatures greater than 100°C. New products can also be formulated to address the customer’s specific application(s). Visit us at Stand 476", "domain": "chemistry", "round": 3} +{"url": "https://digitalcommons.wayne.edu/oa_dissertations/1942/", "date": "2024-02-29T06:04:00Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707947474784.33/warc/CC-MAIN-20240229035411-20240229065411-00016.warc.gz", "language_score": 0.9103650450706482, "token_count": 659, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__4823304", "lang": "en", "text": "Off-campus WSU users: To download campus access dissertations, please use the following link to log into our proxy server with your WSU access ID and password, then click the \"Off-campus Download\" button below.\nNon-WSU users: Please talk to your librarian about requesting this dissertation through interlibrary loan.\nDate of Award\nMIRIAM L. GREENBERG\nAs the signature phospholipid of the mitochondrial membranes, cardiolipin (CL) plays an essential role in mitochondrial bioenergetic functions. Impaired CL metabolism leads to Barth syndrome (BTHS), a severe human genetic disorder resulting from the loss-of-function of the CL transacylase tafazzin. The clinical phenotypes of BTHS including cardio- and skeletal myopathy, exercise intolerance, and lactic acidosis, point to metabolic defects. I utilized both yeast and mouse cells to study the function of CL in metabolic regulation. These studies may contribute to the identification of potential therapeutic strategies for BTHS patients.\nPrevious studies indicated that CL deficient cells exhibit decreased levels of acetyl-CoA and reduced activities of TCA cycle enzymes, aconitase and succinate dehydrogenase (SDH). To gain insight into how CL deficiency affects the TCA cycle, metabolic flux of C13-glucose was analyzed in tafazzin knockout (TAZ-KO) mouse cells. TAZ-KO cells exhibited decreased flux of C13-glucose to acetyl-CoA and TCA cycle intermediates. These deficiencies were associated with decreased activity of pyruvate dehydrogenase (PDH) and SDH in TAZ-KO cells. Importantly, CL was found to bind to the PDH complex and stimulate PDH activity. These studies suggest that CL is required for the optimal activation of PDH, and that PDH and SDH activities are decreased in BTHS.\nAs decreased SDH activity may result from decreased Fe-S biosynthesis in yeast crd1Δ cells, my study suggested that iron homeostasis is also impaired in TAZ-KO mouse cells. Iron defects were assayed in TAZ-KO cells, which exhibit reduced mitochondrial Fe-S enzyme activity and elevated sensitivity to iron and H2O2. In addition, this mutant exhibits up-regulated expression of ferroportin (an iron exporter) and down-regulated expression of transferrin receptor (an iron importer) accompanied by elevated mitochondrial iron. The iron chelator deferoxamine alleviated the sensitivity of TAZ-KO cells to H2O2. Both TAZ-KO mouse cells and BTHS lymphoblasts exhibit decreased frataxin, a protein required for Fe-S biogenesis. Decreased frataxin resulted from defects in mitochondrial import or processing. These findings suggest that loss of tafazzin leads to perturbation of Fe-S biogenesis in mammalian as well as yeast cells.\nLi, Yiran, \"Cardiolipin Deficiency Imposes Metabolic Dysfunction That May Contribute To Barth Syndrome Pathology\" (2017). Wayne State University Dissertations. 1942.", "domain": "chemistry", "round": 3} +{"url": "https://www.fastmarkets.com/insights/mineral-resources-mount-marion-lithium-spodumene-production-down-in-first-quarter/", "date": "2023-11-28T20:16:59Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679099942.90/warc/CC-MAIN-20231128183116-20231128213116-00381.warc.gz", "language_score": 0.9289919137954712, "token_count": 605, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__279954445", "lang": "en", "text": "Mineral Resources’ Mount Marion lithium spodumene production down in first quarter\nAustralian lithium spodumene concentrate producer Mineral Resources has announced lower first-quarter spodumene production at its Mount Marion mine in Western Australia.\nIt produced 106,683 tonnes of lithium spodumene concentrate, at the Mount Marion operation in the south-central region of the state, in the January-March quarter, down by 7.23% from the 115,000 tonnes produced in the previous quarter, Mineral Resources said this week.\nAlthough production was down, the company increased its spodumene concentrate shipments by 18.08% to 111,000 tonnes in the quarter, up from 94,000 tonnes in October-December 2018.\nMount Marion produced a total of 418,711 tonnes of spodumene concentrate in 2018 before former co-owner, Neometals sold its minority stake to enable the formation of a 50:50 joint venture between Mineral Resources and China’s Ganfeng Lithium.\nMineral Resources announced on May 1 that the price for 6% spodumene concentrate shipments for the April-June quarter would be $682.38 per tonne, down from $791.84 per tonne in the January-March quarter.\nFastmarkets latest price assessment for contract lithium spodumene (min 5-6% Li2O) was $600-700 per tonne cif China on April 24, down from $900-970 per tonne on May 30, 2018.\nSpodumene prices fell due to the lower domestic prices in China for lithium carbonate, and lithium hydroxide over the course of the past year, against which the spodumene price is calculated.\nAt Kalgoorlie, just north-east of Mount Marion, Mineral Resources and Ganfeng plan to build a lithium-hydroxide plant to produce 20,000-25,000 tpy of battery-grade lithium hydroxide compounds using the Mount Marion output. This plant is set to start production by mid 2021.\nMineral Resources also entered an exclusive 50:50 agreement with Albemarle in the last quarter of 2018 to jointly produce spodumene at the Wodgina mine in the Pilbara region of Western Australia, with a plan to convert the output into lithium hydroxide.\nCommissioning of a spodumene concentrate plant started in the first quarter of 2019. And production is expected to reach 250,000 tpy within the next two years, with the companies ultimately aiming to increase the annual output to 750,000 tonnes.\nFor the conversion to lithium hydroxide, the companies are aiming to develop a 50,000-tpy battery-grade lithium hydroxide plant in a two-stage process. The initial production capacity is expected to be achieved by 2022, before eventually being ramped up to 100,000 tpy in a second stage.", "domain": "chemistry", "round": 3} +{"url": "https://www.phiphilux.com/technologies/protease_substrates.htm", "date": "2023-02-09T12:32:00Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-06/segments/1674764499966.43/warc/CC-MAIN-20230209112510-20230209142510-00766.warc.gz", "language_score": 0.6626862287521362, "token_count": 1103, "dump": "CC-MAIN-2023-06", "global_id": "webtext-fineweb__CC-MAIN-2023-06__0__154229194", "lang": "en", "text": "Two different views of this peptide are shown.\nNote: First, the peptide backbone assumes a loop conformation similar to\n1. B. Z. Packard, D. D. Toptygin, A. Komoriya, and L. Brand Profluorescenct protease substrates: intramolcular dimers described by the exciton model. Proc. Natl. Acad. Sci. (USA) 93: 11640-11645 (1996).\n2. B. Z. Packard, D. D. Toptygin, A. Komoriya, and L. Brand. The design of fluorogenic protease substrates guided by exciton theory. Meth. Enzym. 278: 15-28 (1997).\n3. B. Z.Packard, A. Komoriya, D. D.Toptygin, and L. Brand. Structural characteristics of fluorophores which form intramolecular H-type dimers in a protease substrate. J. Phys. Chem. B 101: 5070-5074 (1997).\n4. B. Z. Packard, D. D. Toptygin, A. Komoriya, and L. Brand. Characterization of fluorescence quenching in bifluorophoric protease substrates. Biophys. Chem. 67: 167-176 (1997)\n5. B. Z. Packard, D. D. Toptygin, A. Komoriya, and L. Brand. Intramolecular resonance dipole-dipole interactions in a protease substrate. J. Phys. Chem. B 102: 752-758 (1998).\n6. B. Z. Packard, A. Komoriya, V. Nanda, and L. Brand. Intramolecular excitonic dimers in protease substrates: modification of the backbone moiety to probe the H-dimer structure. J. Phys. Chem. B 102: 1820-1827 (1998).\nOn Caspase-3 nomenclature:\n7. E.S. Alnemri et al. Human ICE/CED-3 Protease Nomenclature. Cell 87: 171 (1996)\nOn DEVD-based substrate and inhibitor characteristics:\n8. A. Sarin, M.-L. Wu, and P. A. Henkart. Different Interleukin-1b Converting Enzyme (ICE) family protease requirements for the apoptotic death of T-lymphocytes triggered by diverse stimuli. J. Exp. Med. 184: 2445-2450 (1996)\n9. D. W. Nicholson et. al. Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature 376: 37-43 (1995).\nIntracellular Caspase-3-like activities determination using PhiPhiLux:\n10. H. Hirata, A. Takahashi, S. Kobayashi, S. Yonehara, H. Sawai, T. Okasaki, K. Yamamoto, and M. Sasada. Caspases are activated in a branched protease cascade and control distinct downstream processes in Fas-induced apoptosis. J. Exp. Med. 187: 587-600 (1998)\n11. J. M. Zapata, R. Takahashi, G.S.Salvesen and J.C. Reed. Granzyme release and caspase activation in activated human T-lymphocytes. J. Biol. Chem. 273: 6916-6920 (1998).\n12. R.M. Siegel, D.A. Martin, L.Zheng, S.Y. Ng, J. Cohen, and M.J. Lenardo. Death-effector filaments: novel cytoplasmic structures that recruite caspases and trigger apoptosis. J. Cell Biol. 141: 1243-1253 (1998).\n13. L. Guedez, W.G. Stetler-Stevenson, L. Wolff, J. Wang, P. Fukushima, A. Mansoor, M. Stetler-Stevenson. In vitro suppression of programmed cell death of B cells by tissue inhibitor of metalloproteinases-1. J. Clin. Invest. 102: 2002-10 (1998).\n14. A. Komoriya, B.Z. Packard, M.J. Brown, M.-L. Wu, and P.A. Henkart. A novel intracellular caspase fluorogenic substrate for the early detection of apoptosis in thymocytes. (in preparation).\n207A Perry Parkway, Suite 6\nGaithersburg, MD 20877\nPhone: (301) 987-7881\nFAX: (301) 987-7882\nFor further information, inquiries or comments, please fill out our\ninformation request form\nCopyright © 1998-2019 OncoImmunin, Inc. All rights reserved.", "domain": "chemistry", "round": 3} +{"url": "http://www.oc-ema.com/ebooks/binary-rare-earth-oxides", "date": "2018-12-16T04:51:48Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-51/segments/1544376827252.87/warc/CC-MAIN-20181216025802-20181216051802-00106.warc.gz", "language_score": 0.8708426356315613, "token_count": 880, "dump": "CC-MAIN-2018-51", "global_id": "webtext-fineweb__CC-MAIN-2018-51__0__222311544", "lang": "en", "text": "By G. Adachi,Nobuhito Imanaka,Z.C. Kang\nBinary infrequent Earth Oxides is the 1st publication within the box of infrequent earth oxides that offers insurance from the fundamental technology via to fresh advances. This ebook introduces the original features of the binary infrequent earth oxides with their chemistry, physics and functions. It offers a entire evaluate of all of the features of infrequent earth oxides, crucial for scientists and engineers concerned with infrequent earths, oxides, inorganic fabrics, ceramics, and constructions. The binary infrequent earth oxides convey us numerous fascinating features. knowing their basic mechanisms builds a bridge among solid-state chemistry and fabrics science.\nThe publication starts off with a quick creation to binary infrequent earth oxides, their actual and chemical stabilities, polymorphism, crystal buildings and part transformation and the organization with present purposes. The ebook is going directly to current the band constitution of the oxides utilizing a number of quantum chemical calculations, which belong to a newly built region within the binary infrequent earth oxides. significant to this bankruptcy are the characterizations of electric, magnetic and optical houses, in addition to info of unmarried crystal development and particle coaching tools that experience stepped forward lately. Later chapters pay attention to thermo-chemical houses and hint selection strategies. the ultimate bankruptcy features a number of important functions in a number of fields corresponding to phosphors, glass abrasives, car catalysts, gasoline cells, good electrolytes, sunscreens, iron steels, and organic materials.\nThis e-book is a useful source for fabrics scientists and solid-state physicists and chemists with an curiosity in infrequent earth oxides, in addition to complex scholars and graduates who require an method of familiarize them with this box. This ebook presents tips via a entire evaluate of the entire features of binary infrequent earth oxides.\nRead or Download Binary Rare Earth Oxides PDF\nBest inorganic chemistry books\nAdvances in Inorganic Chemistry offers well timed and informative summaries of the present growth in quite a few topic parts inside inorganic chemistry starting from bio-inorganic to sturdy country reviews. Thisacclaimed serial gains stories written through specialists within the sector and is an necessary connection with complicated researchers.\nThis ebook is a wonderful compilation of state of the art learn in heterogeneous catalysis and similar disciplines – floor technology, organometallic catalysis, and enzymatic catalysis. In 23 chapters through famous specialists, the amount demonstrates diverse techniques utilizing version platforms and their successes in knowing features of heterogeneous catalysis, either steel- and steel oxide-based catalysis in prolonged unmarried crystal and nanostructured catalytic fabrics.\nThe current quantity is the 1st of a chain describing Mn minerals. there was no try to supply a radical (bibliographically whole) insurance of the literature. relatively, a variety of papers used to be undertaken to hide in particular many of the facets of incidence and genesis. Papers that basically point out an incidence of a minerat species with out extra info aren't taken into consideration, other than in the event that they characterize an strange form of incidence.\nThe instruction manual at the Physics and Chemistry of infrequent Earths is a continual sequence of books protecting all facets of infrequent earth technological know-how - chemistry, existence sciences, fabrics technological know-how, and physics. the most emphasis of the instruction manual is on infrequent earth parts [Sc, Y and the lanthanides (La via Lu)] yet each time appropriate, info is usually incorporated at the heavily similar actinide components.\n- Katalytische Metathese von Alkinen: Entwicklung neuer Katalysatoren (BestMasters) (German Edition)\n- International Review of Cell and Molecular Biology: 298\n- Advances in Carbohydrate Chemistry and Biochemistry\n- Liquid Metals: International Series of Monographs In: Natural Philosophy\n- Computer Modeling in Inorganic Crystallography\n- Electrochemistry of Dihydroxybenzene Compounds: Carbon Based Electrodes and Their Uses in Synthesis and Sensors\nAdditional info for Binary Rare Earth Oxides\nBinary Rare Earth Oxides by G. Adachi,Nobuhito Imanaka,Z.C. Kang", "domain": "chemistry", "round": 3} +{"url": "https://scholarworks.utrgv.edu/som_pub/653/", "date": "2023-03-22T09:04:55Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-14/segments/1679296943809.22/warc/CC-MAIN-20230322082826-20230322112826-00034.warc.gz", "language_score": 0.9006099104881287, "token_count": 643, "dump": "CC-MAIN-2023-14", "global_id": "webtext-fineweb__CC-MAIN-2023-14__0__40994556", "lang": "en", "text": "School of Medicine Publications and Presentations\nRegulated internalization of NMDA receptors drives PKD1-mediated suppression of the activity of residual cell-surface NMDA receptors\nConstitutive and regulated internalization of cell surface proteins has been extensively investigated. The regulated internalization has been characterized as a principal mechanism for removing cell-surface receptors from the plasma membrane, and signaling to downstream targets of receptors. However, so far it is still not known whether the functional properties of remaining (non-internalized) receptor/channels may be regulated by internalization of the same class of receptor/channels. The N-methyl-D-aspartate receptor (NMDAR) is a principal subtype of glutamate-gated ion channel and plays key roles in neuronal plasticity and memory functions. NMDARs are well-known to undergo two types of regulated internalization – homologous and heterologous, which can be induced by high NMDA/glycine and DHPG, respectively. In the present work, we investigated effects of regulated NMDAR internalization on the activity of residual cell-surface NMDARs and neuronal functions.\nIn electrophysiological experiments we discovered that the regulated internalization of NMDARs not only reduced the number of cell surface NMDARs but also caused an inhibition of the activity of remaining (non-internalized) surface NMDARs. In biochemical experiments we identified that this functional inhibition of remaining surface NMDARs was mediated by increased serine phosphorylation of surface NMDARs, resulting from the activation of protein kinase D1 (PKD1). Knockdown of PKD1 did not affect NMDAR internalization but prevented the phosphorylation and inhibition of remaining surface NMDARs and NMDAR-mediated synaptic functions.\nThese data demonstrate a novel concept that regulated internalization of cell surface NMDARs not only reduces the number of NMDARs on the cell surface but also causes an inhibition of the activity of remaining surface NMDARs through intracellular signaling pathway(s). Furthermore, modulating the activity of remaining surface receptors may be an effective approach for treating receptor internalization-induced changes in neuronal functions of the CNS.\nFang, XQ., Qiao, H., Groveman, B.R. et al. Regulated internalization of NMDA receptors drives PKD1-mediated suppression of the activity of residual cell-surface NMDA receptors. Mol Brain 8, 75 (2015). https://doi.org/10.1186/s13041-015-0167-1\nCreative Commons License\nThis work is licensed under a Creative Commons Attribution 4.0 International License.\nCopyright © 2015, Fang et al.", "domain": "chemistry", "round": 3} +{"url": "https://www.scientific.net/KEM.280-283.167", "date": "2018-10-18T11:37:23Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-43/segments/1539583511806.8/warc/CC-MAIN-20181018105742-20181018131242-00547.warc.gz", "language_score": 0.7952788472175598, "token_count": 285, "dump": "CC-MAIN-2018-43", "global_id": "webtext-fineweb__CC-MAIN-2018-43__0__16507088", "lang": "en", "text": "Ferroelectric Properties of Bismuth Titanate Ceramics by Sm3+/V5+ Substitution\nThe ferroelectricity of Bi3.2Sm0.8Ti3O12 (BST) and Bi3.2Sm0.8Ti2.97V0.03O12 (BSTV)ceramics prepared at 1100oC by a conventional ceramic technique is investigated. These ceramics possess random-oriented polycrystalline structure. The remanent polarization (Pr) and coercive field (Ec) of the BST ceramics are 16 µC/cm2 and 62kV/cm, respectively. Furthermore, V5+ substitution improves the Pr value of the BST ceramics up to 25µC/cm2, which is larger than that of the BST ceramics. Therefore, the co-substitution of Sm3+ and V5+ in Bi4Ti3O12 (BIT) ceramics is effective for the improvement of its ferroelectricity.\nWei Pan, Jianghong Gong, Chang-Chun Ge and Jing-Feng Li\nM. Chen et al., \"Ferroelectric Properties of Bismuth Titanate Ceramics by Sm3+/V5+ Substitution\", Key Engineering Materials, Vols. 280-283, pp. 167-170, 2005", "domain": "chemistry", "round": 3} +{"url": "https://www.deubiquitinaseinhibitor.com/2017/02/15/tissue-gag-levels-were-calculated-as-micrograms-of-gags-per-milligram-of-defatted-dried-tissue-using-a-blyscan-sulfated-glycosaminoglycan-assay/", "date": "2024-02-29T22:06:46Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707947474853.43/warc/CC-MAIN-20240229202522-20240229232522-00257.warc.gz", "language_score": 0.9163875579833984, "token_count": 690, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__139184922", "lang": "en", "text": "Luciferase assays ended up done with the Twin Luciferase Assay Method (Promega) making use of a Berthold Lumat LB9507 luminometer.Gentamicin (Hospira, Inc.) was received by means of UAB College Clinic. The Baasov lab (Technion-Israel Institute of Technologies) synthesized NB84 . Caffeine (C0750), ellipticine (E3380), cycloheximide (C6255), and G418 (G8168) ended up HeLa cells cultured in DMEM + ten% FBS development media until finally fifty% confluent were dealt with as follows: seven.5 mM caffeine for 4 hrs, 5 mM NMDI-one for 24 hrs, 5 mM ellipticine for 24 hrs, or .81 mM cycloheximide for 2 hrs. Cells ended up then washed and incubated in DMEM (lacking methionine, cysteine, or glutamine) + 10% dialyzed FBS labeling media for thirty minutes at 37uC. The labeling media was then replaced with a 1:1 blend of development and labeling medias made up of medications at the identical concentrations as over and fifty mCi/ml 35S-methionine (EXPRE 35-S labeling combine, Perkin-Elmer NEG-072) for 2 hr at 37uC. Cells have been washed x3 with PBS, scraped in one.five mls chilly 25% trichloroacetic acid (TCA), and then incubated on ice for 30 minutes. TCA-precipitated protein was filtered by way of 934-AH Whatman glass fiber filters and 35S-methionine protein incorporation was identified using a Wallac 1409 liquid scintillation counter. Unlabeled cells taken care of under equivalent conditions have been lysed in 750 ml of chilly M-For each Protein Reagent (Pierce) to figure out complete protein focus. A time training course verified that underneath these experimental problems, 35 S-methionine incorporation was linear.Primary mouse embryonic fibroblasts (MEFs) derived from homozygous WT and IduaW392X mice were incubated +/2 one.eight mM gentamicin or 2.9 mM NB84 for 48 hrs +/two 5 mM NMDI-one for 24 hrs. Assays to determine a- L-iduronidase, bhexosaminidase, and b-glucuronidase pursuits and 114828-90-9E-Endoxifen Sulfated GAG stages had been carried out as previously explained [twenty five]. PD 151746 chemical information Enzyme distinct routines ended up calculated as picomoles of introduced substrate for each milligram of whole protein per hour. Enzyme routines remained linear more than the incubation instances. MEF GAG amounts ended up calculated as nanograms of GAGs for each milligram total protein. Tissue GAG amounts had been calculated as micrograms of GAGs for every milligram of defatted, dried tissue employing a Blyscan Sulfated Glycosaminoglycan Assay, in which chondroitin 6-sulfate was utilised as a reference.", "domain": "chemistry", "round": 3} +{"url": "https://www.onepetro.org/conference-paper/SPE-195045-MS", "date": "2020-09-23T02:54:23Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-40/segments/1600400209665.4/warc/CC-MAIN-20200923015227-20200923045227-00114.warc.gz", "language_score": 0.7989518642425537, "token_count": 1588, "dump": "CC-MAIN-2020-40", "global_id": "webtext-fineweb__CC-MAIN-2020-40__0__199048291", "lang": "en", "text": "Evaluation of a New Environmentally Friendly Flowback Surfactant and Its Application to Enhance Oil and Gas Productivity\n- Ahmed Rabie (Solvay) | Jian Zhou (Solvay) | Qi Qu (Solvay)\n- Document ID\n- Society of Petroleum Engineers\n- SPE Middle East Oil and Gas Show and Conference, 18-21 March, Manama, Bahrain\n- Publication Date\n- Document Type\n- Conference Paper\n- 2019. Society of Petroleum Engineers\n- 2 Well completion, 5.5.2 Core Analysis, 3 Production and Well Operations, 2.5.2 Fracturing Materials (Fluids, Proppant), 2.4 Hydraulic Fracturing\n- flowback surfactant, water recovery, Oil and gas productivity, Interfacial tension, coreflood\n- 2 in the last 30 days\n- 125 since 2007\n- Show more detail\n- View rights & permissions\n|SPE Member Price:||USD 5.00|\n|SPE Non-Member Price:||USD 28.00|\nSurfactants have been used in the oil industry for decades as multi-functions additive in stimulation fluids. In hydraulic fracturing, surfactants and microemulsions have been extensively reported numerously as flowback additives to lower surface and interfacial tension to aid water recovery. Fracturing fluids invade the matrix during the fracturing, and if not recovered, leads to water blockage and a reduction to relative permeability to gas or oil. This problem is more challenging in low- permeability formations since capillary forces have more profound impact on water retention, and hence water recovery and subsequent oil productivity.\nIn this work, surface tension, interfacial tension, foam stability, sand-packed columns, and coreflood experiments were performed on a selected environmentally friendly water-based surfactant formulation. The performance of the surfactant of interest was compared to two commercial microemulsion and one non-ionic alcohol ethoxylated.\nThe results confirmed the benefit of using surfactants for flowback compared to non-surfactant case. Surface tension (ST) alone cannot be used as a selecting criterion for flow back. The alcohol exthoxylated, while reducing the ST to same level as the two microemulsions, showed very poor performance in packed column and coreflood tests. Although interfacial tension (IFT) seems to be more reasonable criteria, adsorption and emulsion tendency are other challenges that can hinder the performance of good surfactants with low IFT. Based on the data, a surfactant that lowers the IFT with the selected oil to below 1 mN/m is more likely to outperform other surfactants with higher IFT.\n|File Size||1 MB||Number of Pages||15|\nCawiezel, K.E., Singh, A.K., Carman, P.S.. 2010. The Selection and Optimization of a Surfactant Package to Maximize Cleanup of a High-Density Fracturing Fluid. Presented at the SPE Deepwater Drilling and Completions Conference, Galveston, Texas, USA, 5–6 October. SPE-136812-MS. https://doi.org/10.2118/136812-MS.\nGalindo, T.A. and Rimassa, S.M. 2013. Evaluation of Environmentally Acceptable Surfactants for Application as Flowback Aids. Presented at the SPE International Symposium on Oilfield Chemistry, The Woodlands, Texas, USA, 8–10 April. SPE-164122-MS. https://doi.org/10.2118/164122-MS.\nKim, J., Zhang, H., Sun, H.. 2016. Choosing Surfactants for the Eagle Ford Shale Formation: Guidelines for Maximizing Flowback and Initial Oil Recovery. Presented at SPE Low Perm Symposium, Denver, Colorado, USA, 5-6 May. SPE-180227-MS. https://doi.org/10.2118/180227-MS.\nKovalchuk, N.M., Trybala, A., Starov, V.. 2014. Fluoro-vs hydrocarbon surfactants: Why do they differ in wetting performance. Advances in Colloid and Interface Science, 210: 65–71. http://dx.doi.org/10.1016/j.cis.2014.04.003.\nMahmoudkhani, A., O'Neil, B., Wylde, J.J.. 2015. Microemulsions as Flowback Aids for Enhanced Oil and Gas Recovery after Fracturing, Myth or Reality: A Turnkey Study to Determine the Features and Benefits. Presented at the SPE International Symposium on Oilfield Chemistry, The Woodlands, Texas, USA, 13–15 April. SPE-173729-MS. https://doi.org/10.2118/173729-MS.\nRabie, A., Zhou J., and Qu, Q. 2019. New Insights in the Characteristics Required for A successful Flowback Surfactant and its Use in Tight and Unconventional Reservoirs. Presented at the 2019 International Petroleum Technology Conference, Bejing, China, 26-28 March. IPTC-19451-MS. https://doi.org/10.2118/122109-MS.\nRostami, A., and Nasr-El-Din, H. A. 2014. Microemulsion vs. Surfactant Assisted Gas Recovery in Low Permeability Formations with Water Blockage. Presented at the SPE Western North American and Rocky Mountain Joint Regional Meeting, Denver, Colorado, USA, 16–18 April. SPE-169582- MS. https://doi.org/10.2118/169582-MS.\nShuler, P. J., Lu, Z., Ma, Q.. 2016. Surfactant Huff-n-Puff Application Potentials for Unconventional Reservoirs. Presented at SPE Improved Oil Recovery Conference, Tulsa, Oklahoma, USA, 11-13 April. SPE-179667-MS. https://doi.org/10.2118/179667-MS.\nZelenev, A. S. and Ellena, L. 2009. Microemulsion Technology for Improved Fluid Recovery and Enhanced Core Permeability to Gas. Presented at the 8th European Formation Damage Conference, Scheveningen, The Netherlands, 27-29 May. SPE-122109-MS. https://doi.org/10.2118/122109-MS.\nZelenev, A. S., Zhou, H., Ellena, L.. 2010. Microemulsion-Assisted Fluid Recovery and Improved Permeability to Gas in Shale Formations. Presented at the International Symposium and Exhibition on Formation Damage Control, Lafayette, Louisiana, USA, 10-12 February. SPE-127922-MS. https://doi.org/10.2118/127922-MS.\nZhang, H., Marinescu, P., and Foxenberg, W. 2012. Unique Flow-Back Chemistry for Enhancing Productivity of Low-Permeability Reservoir. Presented at IADC/SPE Asia Pacific Drilling Technology Conference and Exhibition, Tianjin, China, 9-11 July. SPE-155505-MS. https://doi.org/10.2118/155505-MS.", "domain": "chemistry", "round": 3} +{"url": "https://m.scirp.org/papers/1840", "date": "2022-09-28T23:40:26Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-40/segments/1664030335286.15/warc/CC-MAIN-20220928212030-20220929002030-00152.warc.gz", "language_score": 0.7803261876106262, "token_count": 508, "dump": "CC-MAIN-2022-40", "global_id": "webtext-fineweb__CC-MAIN-2022-40__0__68229726", "lang": "en", "text": "A. Pal, S. Shah and S. Devi, “Synthesis of Au, Ag and Au-Ag Alloy Nanoparticles in Aqueous Polymer Solution,” Colloids Surface A: Physicochemical and Engineering Aspects, Vol. 302, No. 1-3, 2007, pp. 51-57.\n S. H. Choi, Y. P. Zhang, A. Gopalan, K. P. Lee and H. D. Kang, “Preparation of Catalytically Efficient Precious Metallic Colloids by γ-irradiation and Characterization,” Colloids and Surfaces A: Physicochemical and Engineering Aspects, Vol. 256, No. 2-3, 2005, pp. 165-170.\n H. Willwohl, J. Wolfrum, V. Zumbach, P. Albers and K. Seibold, “Production and Characterization of Highly Dispersed Catalytic Active Platinum and Palladium Powers by Excimer Laser Photolysis,” Journal of Physical Chemistry, Vol. 98, 1994, pp. 2242-2247.\n A. Pal, S. Shah and S. Devi, “Preparation of Silver, Gold and Silver-Gold Bimetallic Nanoparticles in w/o Microemulsion Containing TritonX-100,” Colloids and Surfaces A: Physicochemical and Engineering Aspects, Vol. 302, No. 1-3, 2007, pp. 483-487.\n W. S. W. Ngah and K. H. Liang, “Adsorption of Gold(III) Irons onto Chitosan and N-Carboxymethyl Chitosan: Equilibrium Studies,” Industrial and Engineering Chemistry Research, Vol. 38, No. 4, 1999, pp. 1411-1414.\n L. Huang, M. L. Zhai, D. W. Long, J. Peng, et al., “UV-Induced Synthesis, Characterization and Formation Mechanism of Silver Nanoparticles in Alkalic Carboxymethylated Chitosan Solution,” Journal of Nanoparticle Research, Vol. 10, No. 7, 2008, pp. 1193-1202.", "domain": "chemistry", "round": 3} +{"url": "http://wikien4.appspot.com/wiki/Antimony", "date": "2019-03-24T11:38:31Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-13/segments/1552912203438.69/warc/CC-MAIN-20190324103739-20190324125739-00465.warc.gz", "language_score": 0.7131783962249756, "token_count": 12886, "dump": "CC-MAIN-2019-13", "global_id": "webtext-fineweb__CC-MAIN-2019-13__0__127309215", "lang": "en", "text": "|Appearance||siwvery wustrous gray|\n|Standard atomic weight Ar, std(Sb)||121.760(1)|\n|Antimony in de periodic tabwe|\n|Atomic number (Z)||51|\n|Group||group 15 (pnictogens)|\n|Ewectron configuration||[Kr] 4d10 5s2 5p3|\nEwectrons per sheww\n|2, 8, 18, 18, 5|\n|Phase at STP||sowid|\n|Mewting point||903.78 K (630.63 °C, 1167.13 °F)|\n|Boiwing point||1908 K (1635 °C, 2975 °F)|\n|Density (near r.t.)||6.697 g/cm3|\n|when wiqwid (at m.p.)||6.53 g/cm3|\n|Heat of fusion||19.79 kJ/mow|\n|Heat of vaporization||193.43 kJ/mow|\n|Mowar heat capacity||25.23 J/(mow·K)|\n|Oxidation states||−3, −2, −1, +1, +2, +3, +4, +5 (an amphoteric oxide)|\n|Ewectronegativity||Pauwing scawe: 2.05|\n|Atomic radius||empiricaw: 140 pm|\n|Covawent radius||139±5 pm|\n|Van der Waaws radius||206 pm|\n|Spectraw wines of antimony|\n|Speed of sound din rod||3420 m/s (at 20 °C)|\n|Thermaw expansion||11 µm/(m·K) (at 25 °C)|\n|Thermaw conductivity||24.4 W/(m·K)|\n|Ewectricaw resistivity||417 nΩ·m (at 20 °C)|\n|Magnetic susceptibiwity||−99.0·10−6 cm3/mow|\n|Young's moduwus||55 GPa|\n|Shear moduwus||20 GPa|\n|Buwk moduwus||42 GPa|\n|Brineww hardness||294–384 MPa|\n|Discovery||before 800 CE|\n|Main isotopes of antimony|\nAntimony is a chemicaw ewement wif symbow Sb (from Latin: stibium) and atomic number 51. A wustrous gray metawwoid, it is found in nature mainwy as de suwfide mineraw stibnite (Sb2S3). Antimony compounds have been known since ancient times and were powdered for use as medicine and cosmetics, often known by de Arabic name, kohw. Metawwic antimony was awso known, but it was erroneouswy identified as wead upon its discovery. The earwiest known description of de metaw in de West was written in 1540 by Vannoccio Biringuccio.\nFor some time, China has been de wargest producer of antimony and its compounds, wif most production coming from de Xikuangshan Mine in Hunan. The industriaw medods for refining antimony are roasting and reduction wif carbon or direct reduction of stibnite wif iron, uh-hah-hah-hah.\nThe wargest appwications for metawwic antimony is an awwoy wif wead and tin and de wead antimony pwates in wead–acid batteries. Awwoys of wead and tin wif antimony have improved properties for sowders, buwwets, and pwain bearings. Antimony compounds are prominent additives for chworine and bromine-containing fire retardants found in many commerciaw and domestic products. An emerging appwication is de use of antimony in microewectronics.\n- 1 Characteristics\n- 2 Compounds\n- 3 History\n- 4 Production\n- 5 Appwications\n- 6 Precautions\n- 7 See awso\n- 8 Notes\n- 9 References\n- 10 Bibwiography\n- 11 Externaw winks\nAntimony is a member of group 15 of de periodic tabwe, one of de ewements cawwed pnictogens, and has an ewectronegativity of 2.05. In accordance wif periodic trends, it is more ewectronegative dan tin or bismuf, and wess ewectronegative dan tewwurium or arsenic. Antimony is stabwe in air at room temperature, but reacts wif oxygen if heated to produce antimony trioxide, Sb2O3.:758\nAntimony is a siwvery, wustrous gray metawwoid wif a Mohs scawe hardness of 3, which is too soft to make hard objects; coins of antimony were issued in China's Guizhou province in 1931 but de durabiwity was poor and de minting was soon discontinued. Antimony is resistant to attack by acids.\nFour awwotropes of antimony are known: a stabwe metawwic form and dree metastabwe forms (expwosive, bwack and yewwow). Ewementaw antimony is a brittwe, siwver-white shiny metawwoid. When swowwy coowed, mowten antimony crystawwizes in a trigonaw ceww, isomorphic wif de gray awwotrope of arsenic. A rare expwosive form of antimony can be formed from de ewectrowysis of antimony trichworide. When scratched wif a sharp impwement, an exodermic reaction occurs and white fumes are given off as metawwic antimony forms; when rubbed wif a pestwe in a mortar, a strong detonation occurs. Bwack antimony is formed upon rapid coowing of antimony vapor. It has de same crystaw structure as red phosphorus and bwack arsenic, it oxidizes in air and may ignite spontaneouswy. At 100 °C, it graduawwy transforms into de stabwe form. The yewwow awwotrope of antimony is de most unstabwe. It has onwy been generated by oxidation of stibine (SbH3) at −90 °C. Above dis temperature and in ambient wight, dis metastabwe awwotrope transforms into de more stabwe bwack awwotrope.\nEwementaw antimony adopts a wayered structure (space group R3m No. 166) in which wayers consist of fused, ruffwed, six-membered rings. The nearest and next-nearest neighbors form an irreguwar octahedraw compwex, wif de dree atoms in each doubwe wayer swightwy cwoser dan de dree atoms in de next. This rewativewy cwose packing weads to a high density of 6.697 g/cm3, but de weak bonding between de wayers weads to de wow hardness and brittweness of antimony.:758\nAntimony has two stabwe isotopes: 121Sb wif a naturaw abundance of 57.36% and 123Sb wif a naturaw abundance of 42.64%. It awso has 35 radioisotopes, of which de wongest-wived is 125Sb wif a hawf-wife of 2.75 years. In addition, 29 metastabwe states have been characterized. The most stabwe of dese is 120m1Sb wif a hawf-wife of 5.76 days. Isotopes dat are wighter dan de stabwe 123Sb tend to decay by β+ decay, and dose dat are heavier tend to decay by β− decay, wif some exceptions.\nThe abundance of antimony in de Earf's crust is estimated to be 0.2 to 0.5 parts per miwwion, comparabwe to dawwium at 0.5 parts per miwwion and siwver at 0.07 ppm. Even dough dis ewement is not abundant, it is found in more dan 100 mineraw species. Antimony is sometimes found nativewy (e.g. on Antimony Peak), but more freqwentwy it is found in de suwfide stibnite (Sb2S3) which is de predominant ore mineraw.\nOxides and hydroxides\nAntimony trioxide is formed when antimony is burnt in air. In de gas phase, de mowecuwe of de compound is Sb\n6, but it powymerizes upon condensing. Antimony pentoxide (Sb\n10) can be formed onwy by oxidation wif concentrated nitric acid. Antimony awso forms a mixed-vawence oxide, antimony tetroxide (Sb\n4), which features bof Sb(III) and Sb(V). Unwike oxides of phosphorus and arsenic, dese oxides are amphoteric, do not form weww-defined oxoacids, and react wif acids to form antimony sawts.\nAntimonous acid Sb(OH)\n3 is unknown, but de conjugate base sodium antimonite ([Na\n4) forms upon fusing sodium oxide and Sb\n6.:763 Transition metaw antimonites are awso known, uh-hah-hah-hah.:122 Antimonic acid exists onwy as de hydrate HSb(OH)\n6, forming sawts as de antimonate anion Sb(OH)−\n6. When a sowution containing dis anion is dehydrated, de precipitate contains mixed oxides.:143\nMany antimony ores are suwfides, incwuding stibnite (Sb\n3), pyrargyrite (Ag\n3), zinkenite, jamesonite, and bouwangerite.:757 Antimony pentasuwfide is non-stoichiometric and features antimony in de +3 oxidation state and S-S bonds. Severaw dioantimonides are known, such as [Sb\n3 + 6 HF → 2 SbF\n3 + 3 H\nIt is Lewis acidic and readiwy accepts fwuoride ions to form de compwex anions SbF−\n4 and SbF2−\n5. Mowten SbF\n3 is a weak ewectricaw conductor. The trichworide SbCw\n3 is prepared by dissowving Sb\n3 in hydrochworic acid:\n3 + 6 HCw → 2 SbCw\n3 + 3 H\nThe pentahawides SbF\n5 and SbCw\n5 have trigonaw bipyramidaw mowecuwar geometry in de gas phase, but in de wiqwid phase, SbF\n5 is powymeric, whereas SbCw\n5 is monomeric.:761 SbF\n5 is a powerfuw Lewis acid used to make de superacid fwuoroantimonic acid (\"H2SbF7\").\nAntimonides, hydrides, and organoantimony compounds\nCompounds in dis cwass generawwy are described as derivatives of Sb3−. Antimony forms antimonides wif metaws, such as indium antimonide (InSb) and siwver antimonide (Ag\n3Sb).:760 The awkawi metaw and zinc antimonides, such as Na3Sb and Zn3Sb2, are more reactive. Treating dese antimonides wif acid produces de highwy unstabwe gas stibine, SbH\n+ 3 H+\nStibine can awso be produced by treating Sb3+\nsawts wif hydride reagents such as sodium borohydride. Stibine decomposes spontaneouswy at room temperature. Because stibine has a positive heat of formation, it is dermodynamicawwy unstabwe and dus antimony does not react wif hydrogen directwy.\nOrganoantimony compounds are typicawwy prepared by awkywation of antimony hawides wif Grignard reagents. A warge variety of compounds are known wif bof Sb(III) and Sb(V) centers, incwuding mixed chworo-organic derivatives, anions, and cations. Exampwes incwude Sb(C6H5)3 (triphenywstibine), Sb2(C6H5)4 (wif an Sb-Sb bond), and cycwic [Sb(C6H5)]n. Pentacoordinated organoantimony compounds are common, exampwes being Sb(C6H5)5 and severaw rewated hawides.\nAn artifact, said to be part of a vase, made of antimony dating to about 3000 BC was found at Tewwoh, Chawdea (part of present-day Iraq), and a copper object pwated wif antimony dating between 2500 BC and 2200 BC has been found in Egypt. Austen, at a wecture by Herbert Gwadstone in 1892 commented dat \"we onwy know of antimony at de present day as a highwy brittwe and crystawwine metaw, which couwd hardwy be fashioned into a usefuw vase, and derefore dis remarkabwe 'find' (artifact mentioned above) must represent de wost art of rendering antimony mawweabwe.\"\nMoorey was unconvinced de artifact was indeed a vase, mentioning dat Sewimkhanov, after his anawysis of de Tewwo object (pubwished in 1975), \"attempted to rewate de metaw to Transcaucasian naturaw antimony\" (i.e. native metaw) and dat \"de antimony objects from Transcaucasia are aww smaww personaw ornaments.\" This weakens de evidence for a wost art \"of rendering antimony mawweabwe.\"\nThe Roman schowar Pwiny de Ewder described severaw ways of preparing antimony suwfide for medicaw purposes in his treatise Naturaw History. Pwiny de Ewder awso made a distinction between \"mawe\" and \"femawe\" forms of antimony; de mawe form is probabwy de suwfide, whiwe de femawe form, which is superior, heavier, and wess friabwe, has been suspected to be native metawwic antimony.\nThe first description of a procedure for isowating antimony is in de 1540 book De wa pirotechnia by Vannoccio Biringuccio, predating de more famous 1556 book by Agricowa, De re metawwica. In dis context Agricowa has been often incorrectwy credited wif de discovery of metawwic antimony. The book Currus Triumphawis Antimonii (The Triumphaw Chariot of Antimony), describing de preparation of metawwic antimony, was pubwished in Germany in 1604. It was purported to be written by a Benedictine monk, writing under de name Basiwius Vawentinus in de 15f century; if it were audentic, which it is not, it wouwd predate Biringuccio.[note 1]\nThe metaw antimony was known to German chemist Andreas Libavius in 1615 who obtained it by adding iron to a mowten mixture of antimony suwfide, sawt and potassium tartrate. This procedure produced antimony wif a crystawwine or starred surface.\nThe first discovery of naturawwy occurring pure antimony in de Earf's crust was described by de Swedish scientist and wocaw mine district engineer Anton von Swab in 1783; de type-sampwe was cowwected from de Sawa Siwver Mine in de Bergswagen mining district of Sawa, Västmanwand, Sweden.\nThe medievaw Latin form, from which de modern wanguages and wate Byzantine Greek take deir names for antimony, is antimonium. The origin of dis is uncertain; aww suggestions have some difficuwty eider of form or interpretation, uh-hah-hah-hah. The popuwar etymowogy, from ἀντίμοναχός anti-monachos or French antimoine, stiww has adherents; dis wouwd mean \"monk-kiwwer\", and is expwained by many earwy awchemists being monks, and antimony being poisonous.\nAnoder popuwar etymowogy is de hypodeticaw Greek word ἀντίμόνος antimonos, \"against awoneness\", expwained as \"not found as metaw\", or \"not found unawwoyed\". Lippmann conjectured a hypodeticaw Greek word ανθήμόνιον andemonion, which wouwd mean \"fworet\", and cites severaw exampwes of rewated Greek words (but not dat one) which describe chemicaw or biowogicaw effworescence.\nThe earwy uses of antimonium incwude de transwations, in 1050–1100, by Constantine de African of Arabic medicaw treatises. Severaw audorities bewieve antimonium is a scribaw corruption of some Arabic form; Meyerhof derives it from idmid; oder possibiwities incwude adimar, de Arabic name of de metawwoid, and a hypodeticaw as-stimmi, derived from or parawwew to de Greek.\nThe ancient words for antimony mostwy have, as deir chief meaning, kohw, de suwfide of antimony.\nThe Egyptians cawwed antimony mśdmt; in hierogwyphs, de vowews are uncertain, but de Coptic form of de word is ⲥⲧⲏⲙ (stēm). The Greek word, στίμμι stimmi, is probabwy a woan word from Arabic or from Egyptian stm\nand is used by Attic tragic poets of de 5f century BC. Later Greeks awso used στἰβι stibi, as did Cewsus and Pwiny, writing in Latin, in de first century AD. Pwiny awso gives de names stimi [sic], warbaris, awabaster, and de \"very common\" pwatyophdawmos, \"wide-eye\" (from de effect of de cosmetic). Later Latin audors adapted de word to Latin as stibium. The Arabic word for de substance, as opposed to de cosmetic, can appear as إثمد idmid, admoud, odmod, or udmod. Littré suggests de first form, which is de earwiest, derives from stimmida, an accusative for stimmi.\nTop producers and production vowumes\nThe British Geowogicaw Survey (BGS) reported dat in 2005 China was de top producer of antimony wif approximatewy 84% of de worwd share, fowwowed at a distance by Souf Africa, Bowivia and Tajikistan, uh-hah-hah-hah. Xikuangshan Mine in Hunan province has de wargest deposits in China wif an estimated deposit of 2.1 miwwion metric tons.\n|Country||Tonnes||% of totaw|\nChinese production of antimony is expected to decwine in de future as mines and smewters are cwosed down by de government as part of powwution controw. Especiawwy due to a new environmentaw protection waw having gone into effect on January 2015 and revised “Emission Standards of Powwutants for Stanum, Antimony, and Mercury” having gone into effect, hurdwes for economic production are higher. According to de Nationaw Bureau of Statistics in China, by September 2015 50% of antimony production capacity in de Hunan province (de province wif biggest antimony reserves in China) had not been used.\nReported production of antimony in China has fawwen and is unwikewy to increase in de coming years, according to de Roskiww report. No significant antimony deposits in China have been devewoped for about ten years, and de remaining economic reserves are being rapidwy depweted.\nThe worwd's wargest antimony producers, according to Roskiww, are wisted bewow:\n(tonnes per year)\n|China||Hsikwangshan Twinkwing Star||55,000|\n|China||Hunan Chenzhou Mining||20,000|\n|China||China Tin Group||20,000|\n|China||Shenyang Huachang Antimony||15,000|\n|Souf Africa||Consowidated Murchison||6,000|\n|Turkey||Cengiz & Özdemir Antimuan Madenweri||2,400|\nAccording to statistics from de USGS, current gwobaw reserves of antimony wiww be depweted in 13 years. However, de USGS expects more resources wiww be found.\n(tonnes of antimony content)\n|% of totaw|\n|Peopwe's Repubwic of China||950,000||47.81|\nThe extraction of antimony from ores depends on de qwawity and composition of de ore. Most antimony is mined as de suwfide; wower-grade ores are concentrated by frof fwotation, whiwe higher-grade ores are heated to 500–600 °C, de temperature at which stibnite mewts and separates from de gangue mineraws. Antimony can be isowated from de crude antimony suwfide by reduction wif scrap iron:\n3 + 3 Fe → 2 Sb + 3 FeS\nThe suwfide is converted to an oxide; de product is den roasted, sometimes for de purpose of vaporizing de vowatiwe antimony(III) oxide, which is recovered. This materiaw is often used directwy for de main appwications, impurities being arsenic and suwfide. Antimony is isowated from de oxide by a carbodermaw reduction:\n- 2 Sb\n3 + 3 C → 4 Sb + 3 CO\nSuppwy risk and criticaw mineraw rankings\nAntimony has consistentwy been ranked high in European and US risk wists concerning criticawity of de ewement indicating de rewative risk to de suppwy of chemicaw ewements or ewement groups reqwired to maintain de current economy and wifestywe.\nWif most of de antimony imported into Europe and de US coming from China, Chinese production is criticaw to suppwy. As China is revising and increasing environmentaw controw standards, antimony production is becoming increasingwy restricted. Additionawwy Chinese export qwotas for antimony have been decreasing in de past years. These two factors increase suppwy risk for bof Europe and US.\nAccording to de BGS Risk List 2015, antimony is ranked second highest (after rare earf ewements) on de rewative suppwy risk index. This indicates dat it has currentwy de second highest suppwy risk for chemicaw ewements or ewement groups which are of economic vawue to de British economy and wifestywe. Furdermore, antimony was identified as one of 20 criticaw raw materiaws for de EU in a report pubwished in 2014 (which revised de initiaw report pubwished in 2011). As seen in Figure xxx antimony maintains high suppwy risk rewative to its economic importance. 92% of de antimony is imported from China, which is a significantwy high concentration of production, uh-hah-hah-hah.\nMuch anawysis has been conducted in de U.S. toward defining which metaws shouwd be cawwed strategic or criticaw to de nation's security. Exact definitions do not exist, and views as to what constitutes a strategic or criticaw mineraw to U.S. security diverge.\nIn 2015, no antimony was mined in de U.S. The metaw is imported from foreign countries. From 2011-2014 68% of America's antimony came from China, 14% from India, 4% from Mexico, and 14% from oder sources. There are no pubwicwy known government stockpiwes in pwace currentwy.\nThe U.S. “Subcommittee on Criticaw and Strategic Mineraw Suppwy Chains” has screened 78 mineraw resources from 1996-2008. It found dat a smaww subset of mineraws incwuding antimony has fawwen into de category of potentiawwy criticaw mineraws consistentwy. In de future, a second assessment wiww be made of de found subset of mineraws to identify which shouwd be defined of significant risk and criticaw to U.S. interests.\nAntimony is mainwy used as de trioxide for fwame-proofing compounds, awways in combination wif hawogenated fwame retardants except in hawogen-containing powymers. The fwame retarding effect of antimony trioxide is produced by de formation of hawogenated antimony compounds, which react wif hydrogen atoms, and probabwy awso wif oxygen atoms and OH radicaws, dus inhibiting fire. Markets for dese fwame-retardants incwude chiwdren's cwoding, toys, aircraft, and automobiwe seat covers. They are awso added to powyester resins in fibergwass composites for such items as wight aircraft engine covers. The resin wiww burn in de presence of an externawwy generated fwame, but wiww extinguish when de externaw fwame is removed.\nAntimony forms a highwy usefuw awwoy wif wead, increasing its hardness and mechanicaw strengf. For most appwications invowving wead, varying amounts of antimony are used as awwoying metaw. In wead–acid batteries, dis addition improves pwate strengf and charging characteristics. It is used in antifriction awwoys (such as Babbitt metaw), in buwwets and wead shot, ewectricaw cabwe sheading, type metaw (for exampwe, for winotype printing machines), sowder (some \"wead-free\" sowders contain 5% Sb), in pewter, and in hardening awwoys wif wow tin content in de manufacturing of organ pipes.\nThree oder appwications consume nearwy aww de rest of de worwd's suppwy. One appwication is as a stabiwizer and catawyst for de production of powyedywene terephdawate. Anoder is as a fining agent to remove microscopic bubbwes in gwass, mostwy for TV screens; antimony ions interact wif oxygen, suppressing de tendency of de watter to form bubbwes. The dird appwication is pigments.\nAntimony is increasingwy being used in semiconductors as a dopant in n-type siwicon wafers for diodes, infrared detectors, and Haww-effect devices. In de 1950s, de emitters and cowwectors of n-p-n awwoy junction transistors were doped wif tiny beads of a wead-antimony awwoy. Indium antimonide is used as a materiaw for mid-infrared detectors.\nBiowogy and medicine have few uses for antimony. Treatments containing antimony, known as antimoniaws, are used as emetics. Antimony compounds are used as antiprotozoan drugs. Potassium antimonyw tartrate, or tartar emetic, was once used as an anti-schistosomaw drug from 1919 on, uh-hah-hah-hah. It was subseqwentwy repwaced by praziqwantew. Antimony and its compounds are used in severaw veterinary preparations, such as andiomawine and widium antimony diomawate, as a skin conditioner in ruminants. Antimony has a nourishing or conditioning effect on keratinized tissues in animaws.\nAntimony-based drugs, such as megwumine antimoniate, are awso considered de drugs of choice for treatment of weishmaniasis in domestic animaws. Unfortunatewy, besides having wow derapeutic indices, de drugs have minimaw penetration of de bone marrow, where some of de Leishmania amastigotes reside, and curing de disease – especiawwy de visceraw form – is very difficuwt. Ewementaw antimony as an antimony piww was once used as a medicine. It couwd be reused by oders after ingestion and ewimination, uh-hah-hah-hah.\nAntimony suwfides hewp to stabiwize de friction coefficient in automotive brake pad materiaws.\nAntimony-124 is used togeder wif berywwium in neutron sources; de gamma rays emitted by antimony-124 initiate de photodisintegration of berywwium. The emitted neutrons have an average energy of 24 keV. Naturaw antimony is used in startup neutron sources.\nThe effects of antimony and its compounds on human and environmentaw heawf differ widewy. Ewementaw antimony metaw does not affect human and environmentaw heawf. Inhawation of antimony trioxide (and simiwar poorwy sowubwe Sb(III) dust particwes such as antimony dust) is considered harmfuw and suspected of causing cancer. However, dese effects are onwy observed wif femawe rats and after wong-term exposure to high dust concentrations. The effects are hypodesized to be attributed to inhawation of poorwy sowubwe Sb particwes weading to impaired wung cwearance, wung overwoad, infwammation and uwtimatewy tumour formation, not to exposure to antimony ions (OECD, 2008). Antimony chworides are corrosive to skin, uh-hah-hah-hah. The effects of antimony are not comparabwe to dose of arsenic; dis might be caused by de significant differences of uptake, metabowism, and excretion between arsenic and antimony.\nFor oraw absorption, ICRP (1994) has recommended vawues of 10% for tartar emetic and 1% for aww oder antimony compounds. Dermaw absorption for metaws is estimated to be at most 1% (HERAG, 2007). Inhawation absorption of antimony trioxide and oder poorwy sowubwe Sb(III) substances (such as antimony dust) is estimated at 6.8% (OECD, 2008), whereas a vawue <1% is derived for Sb(V) substances. Antimony(V) is not qwantitativewy reduced to antimony(III) in de ceww, and bof species exist simuwtaneouswy.\nAntimony is mainwy excreted from de human body via urine. Antimony and its compounds do not cause acute human heawf effects, wif de exception of antimony potassium tartrate (\"tartar emetic\"), a prodrug dat is intentionawwy used to treat weishmaniasis patients.\nProwonged skin contact wif antimony dust may cause dermatitis. However, it was agreed at de European Union wevew dat de skin rashes observed are not substance-specific, but most probabwy due to a physicaw bwocking of sweat ducts (ECHA/PR/09/09, Hewsinki, 6 Juwy 2009). Antimony dust may awso be expwosive when dispersed in de air; when in a buwk sowid it is not combustibwe.\nThe 8-hour time-weighted average (TWA) is set at 0.5 mg/m3 by de American Conference of Governmentaw Industriaw Hygienists and by de Occupationaw Safety and Heawf Administration (OSHA) as a wegaw permissibwe exposure wimit (PEL) in de workpwace. The Nationaw Institute for Occupationaw Safety and Heawf (NIOSH) has set a recommended exposure wimit (REL) of 0.5 mg/m3 as an 8 hour TWA. Antimony compounds are used as catawysts for powyedywene terephdawate (PET) production, uh-hah-hah-hah. Some studies report minor antimony weaching from PET bottwes into wiqwids, but wevews are bewow drinking water guidewines. Antimony concentrations in fruit juice concentrates were somewhat higher (up to 44.7 µg/L of antimony), but juices do not faww under de drinking water reguwations. The drinking water guidewines are:\n- Worwd Heawf Organization: 20 µg/L\n- Japan: 15 µg/L\n- United States Environmentaw Protection Agency, Heawf Canada and de Ontario Ministry of Environment: 6 µg/L\n- EU and German Federaw Ministry of Environment: 5 µg/L\nCertain compounds of antimony appear to be toxic, particuwarwy antimony trioxide and antimony potassium tartrate. Effects may be simiwar to arsenic poisoning. Occupationaw exposure may cause respiratory irritation, pneumoconiosis, antimony spots on de skin, gastrointestinaw symptoms, and cardiac arrhydmias. In addition, antimony trioxide is potentiawwy carcinogenic to humans.\nAdverse heawf effects have been observed in humans and animaws fowwowing inhawation, oraw, or dermaw exposure to antimony and antimony compounds. Antimony toxicity typicawwy occurs eider due to occupationaw exposure, during derapy or from accidentaw ingestion, uh-hah-hah-hah. It is uncwear if antimony can enter de body drough de skin, uh-hah-hah-hah.\n- Awready in 1710 Wiwhewm Gottwob Freiherr von Leibniz, after carefuw inqwiry, concwuded de work was spurious, dere was no monk named Basiwius Vawentinus, and de book's audor was its ostensibwe editor, Johann Thöwde (c. 1565 – c. 1624). Professionaw historians now agree de Currus Triumphawis ... was written after de middwe of de 16f century and Thöwde was wikewy its audor.\n- Meija, J.; et aw. (2016). \"Atomic weights of de ewements 2013 (IUPAC Technicaw Report)\". Pure and Appwied Chemistry. 88 (3): 265–91. doi:10.1515/pac-2015-0305.\n- Lide, D. R., ed. (2005). \"Magnetic susceptibiwity of de ewements and inorganic compounds\". CRC Handbook of Chemistry and Physics (PDF) (86f ed.). Boca Raton (FL): CRC Press. ISBN 0-8493-0486-5.\n- Weast, Robert (1984). CRC, Handbook of Chemistry and Physics. Boca Raton, Fworida: Chemicaw Rubber Company Pubwishing. pp. E110. ISBN 0-8493-0464-4.\n- David Kimhi's Commentary on Jeremiah 4:30 and I Chronicwes 29:2; Hebrew: פוך/כְּחֻל, Aramaic: כּוּחְלִי/צדידא; Arabic: كحل, and which can awso refer to antimony trisuwfide. See awso Z. Dori, Antimony and Henna (Heb. הפוך והכופר), Jerusawem 1983 (Hebrew).\n- Wiberg, Egon; Wiberg, Niws & Howweman, Arnowd Frederick (2001). Inorganic chemistry. Academic Press. ISBN 978-0-12-352651-9.\n- \"Metaws Used in Coins and Medaws\". ukcoinpics.co.uk.\n- \"Antimony\" in Kirk-Odmer Encycwopedia of Chemicaw Technowogy, 5f ed. 2004. ISBN 978-0-471-48494-3\n- Wang, Chung Wu (1919). \"The Chemistry of Antimony\" (PDF). Antimony: Its History, Chemistry, Minerawogy, Geowogy, Metawwurgy, Uses, Preparation, Anawysis, Production and Vawuation wif Compwete Bibwiographies. London, United Kingdom: Charwes Geiffin and Co. Ltd. pp. 6–33.\n- Norman, Nichowas C (1998). Chemistry of arsenic, antimony, and bismuf. pp. 50–51. ISBN 978-0-7514-0389-3.\n- Georges, Audi; Bersiwwon, O.; Bwachot, J.; Wapstra, A. H. (2003). \"The NUBASE Evawuation of Nucwear and Decay Properties\". Nucwear Physics A. 729 (1): 3–128. Bibcode:2003NuPhA.729....3A. CiteSeerX 10.1.1.692.8504. doi:10.1016/j.nucwphysa.2003.11.001.\n- \"Mineraw Commodity Summaries: Antimony\" (PDF). United States Geowogicaw Survey. Retrieved 1 January 2016.\n- Greenwood, N. N.; & Earnshaw, A. (1997). Chemistry of de Ewements (2nd Edn, uh-hah-hah-hah.), Oxford: Butterworf-Heinemann, uh-hah-hah-hah. ISBN 0-7506-3365-4.\n- Reger, Daniew L.; Goode, Scott R. & Baww, David W. (2009). Chemistry: Principwes and Practice (3rd ed.). Cengage Learning. p. 883. ISBN 978-0-534-42012-3.\n- House, James E. (2008). Inorganic chemistry. Academic Press. p. 502. ISBN 978-0-12-356786-4.\n- Godfrey, S. M.; McAuwiffe, C. A.; Mackie, A. G. & Pritchard, R. G. (1998). Norman, Nichowas C., ed. Chemistry of arsenic, antimony, and bismuf. Springer. ISBN 978-0-7514-0389-3.\n- Long, G.; Stevens, J. G.; Bowen, L. H.; Ruby, S. L. (1969). \"The oxidation number of antimony in antimony pentasuwfide\". Inorganic and Nucwear Chemistry Letters. 5: 21. doi:10.1016/0020-1650(69)80231-X.\n- Lees, R.; Poweww, A.; Chippindawe, A. (2007). \"The syndesis and characterisation of four new antimony suwphides incorporating transition-metaw compwexes\". Journaw of Physics and Chemistry of Sowids. 68 (5–6): 1215. Bibcode:2007JPCS...68.1215L. doi:10.1016/j.jpcs.2006.12.010.\n- Kahwenberg, Louis (2008). Outwines of Chemistry – A Textbook for Cowwege Students. READ BOOKS. pp. 324–325. ISBN 978-1-4097-6995-8.\n- Ewschenbroich, C. \"Organometawwics\" (2006) Wiwey-VCH: Weinheim. ISBN 3-527-29390-6\n- Shortwand, A. J. (2006). \"Appwication of Lead Isotope Anawysis to a Wide Range of Late Bronze Age Egyptian Materiaws\". Archaeometry. 48 (4): 657. doi:10.1111/j.1475-4754.2006.00279.x.\n- Moorey, P. R. S. (1994). Ancient Mesopotamian Materiaws and Industries: de Archaeowogicaw Evidence. New York: Cwarendon Press. p. 241. ISBN 978-1-57506-042-2.\n- Mewwor, Joseph Wiwwiam (1964). \"Antimony\". A comprehensive treatise on inorganic and deoreticaw chemistry. 9. p. 339.\n- Pwiny, Naturaw history, 33.33; W.H.S. Jones, de Loeb Cwassicaw Library transwator, suppwies a note suggesting de identifications.\n- Vannoccio Biringuccio, De wa Pirotechnia (Venice (Itawy): Curtio Navo e fratewwi, 1540), Book 2, chapter 3: Dew antimonio & sua miniera, Capitowo terzo (On antimony and its ore, dird chapter), pp. 27-28. [Note: Onwy every second page of dis book is numbered, so de rewevant passage is to be found on de 74f and 75f pages of de text.] (in Itawian)\n- Priesner, Cwaus; Figawa, Karin, eds. (1998). Awchemie. Lexikon einer hermetischen Wissenschaft (in German). München: C.H. Beck.\n- s.v. \"Basiwius Vawentinus.\" Harowd Jantz was perhaps de onwy modern schowar to deny Thöwde's audorship, but he too agrees de work dates from after 1550: see his catawogue of German Baroqwe witerature.\n- Weeks, Mary Ewvira (1932). \"The discovery of de ewements. II. Ewements known to de awchemists\". Journaw of Chemicaw Education. 9 (1): 11. Bibcode:1932JChEd...9...11W. doi:10.1021/ed009p11.\n- \"Native antimony\". Mindat.org.\n- Kwaprof, M. (1803). \"XL. Extracts from de dird vowume of de anawyses\". Phiwosophicaw Magazine. Series 1. 17 (67): 230. doi:10.1080/14786440308676406.\n- Harper, Dougwas. \"antimony\". Onwine Etymowogy Dictionary.\n- Fernando, Diana (1998). Awchemy: an iwwustrated A to Z. Bwandford. Fernando even derives it from de story of how \"Basiw Vawentine\" and his fewwow monastic awchemists poisoned demsewves by working wif antimony; antimonium is found two centuries before his time. \"Popuwar etymowogy\" from OED; as for antimonos, de pure negative wouwd be more naturawwy expressed by a- \"not\".\n- Lippman, pp. 643–5\n- Lippman, p. 642, writing in 1919, says \"zuerst\".\n- Meyerhof as qwoted in Sarton, asserts dat idmid or admoud became corrupted in de medievaw \"traductions barbaro-watines\".; de OED asserts some Arabic form is de origin, and if idmid is de root, posits adimodium, atimodium, atimonium, as intermediate forms.\n- Endwich, p. 28; one of de advantages of as-stimmi wouwd be dat it has a whowe sywwabwe in common wif antimonium.\n- Endwich, F. M. (1888). \"On Some Interesting Derivations of Mineraw Names\". The American Naturawist. 22 (253): 21–32. doi:10.1086/274630. JSTOR 2451020.\n- In his wong articwe on chemicaw reactions and nomencwature – Jöns Jacob Berzewius, \"Essay on de cause of chemicaw proportions, and on some circumstances rewating to dem: togeder wif a short and easy medod of expressing dem,\" Annaws of Phiwosophy, vow. 2, pages 443–454 (1813) and vow. 3, pages 51–62, 93–106, 244–255, 353–364 (1814) – on page 52, Berzewius wists de symbow for antimony as \"St\"; however, starting on page 248, Berzewius subseqwentwy uses de symbow \"Sb\" for antimony.\n- Awbright, W. F. (1918). \"Notes on Egypto-Semitic Etymowogy. II\". The American Journaw of Semitic Languages and Literatures. 34 (4): 215–255 . doi:10.1086/369866. JSTOR 528157.\n- Sarton, George (1935). Transwated by Max Meyerhof. \"Review of Aw-morchid fi'w-kohhw, ou Le guide d'ocuwistiqwe\". Isis (in French). 22 (2): 539–542 . doi:10.1086/346926. JSTOR 225136. qwotes Meyerhof, de transwator of de book he is reviewing.\n- LSJ, s.v., vocawisation, spewwing, and decwension vary; Endwich, p. 28; Cewsus, 6.6.6 ff; Pwiny Naturaw History 33.33; Lewis and Short: Latin Dictionary. OED, s. \"antimony\".\n- Peng, J.; Hu, R.-Z.; Burnard, P. G. (2003). \"Samarium–neodymium isotope systematics of hydrodermaw cawcites from de Xikuangshan antimony deposit (Hunan, China): de potentiaw of cawcite as a geochronometer\". Chemicaw Geowogy. 200 (1–2): 129. Bibcode:2003ChGeo.200..129P. doi:10.1016/S0009-2541(03)00187-6.\n- \"United States Geowogicaw Mineraw Commodity Summary\" (PDF).\n- \"Environmentaw Protection Law of de Peopwe's Repubwic of China\" (PDF). 24 Apriw 2014.\n- \"U.S. Geowogicaw Survey, Mineraw Commodity Summaries: Antimony\" (PDF). 1 January 2016.\n- \"Study of de antimony market by Roskiww Consuwting Group\" (PDF). Archived from de originaw (PDF) on 18 October 2012. Retrieved 9 Apriw 2012.\n- Antimony Uses, Production and Prices Primer Archived 25 October 2012 at de Wayback Machine Archived 25 October 2012 at de Wayback Machine. tri-starresources.com\n- Butterman, C.; Carwin, Jr., J. F. (2003). \"Mineraw Commodity Profiwes: Antimony\" (PDF). United States Geowogicaw Survey.\n- Grund, Sabina C.; Hanusch, Kunibert; Breunig, Hans J.; Wowf, Hans Uwe (2006) \"Antimony and Antimony Compounds\" in Uwwmann's Encycwopedia of Industriaw Chemistry, Wiwey-VCH, Weinheim. doi:10.1002/14356007.a03_055.pub2\n- Norman, Nichowas C (1998). Chemistry of arsenic, antimony, and bismuf. p. 45. ISBN 978-0-7514-0389-3.\n- Wiwson, N. J.; Craw, D.; Hunter, K. (2004). \"Antimony distribution and environmentaw mobiwity at an historic antimony smewter site, New Zeawand\". Environmentaw Powwution. 129 (2): 257–66. doi:10.1016/j.envpow.2003.10.014. PMID 14987811.\n- \"MinerawsUK Risk List 2015\".\n- \"Review of de wist of criticaw raw materiaws for de EU and de impwementation of de Raw Materiaws Initiative\".\n- \"American Resources Powicy Network Report\" (PDF).\n- \"Criticaw Raw Materiaws\".\n- Weiw, Edward D.; Levchik, Sergei V. (4 June 2009). \"Antimony trioxide and Rewated Compounds\". Fwame retardants for pwastics and textiwes: Practicaw appwications. ISBN 978-3-446-41652-9.\n- Hastie, John W. (1973). \"Mass spectrometric studies of fwame inhibition: Anawysis of antimony trihawides in fwames\". Combustion and Fwame. 21: 49. doi:10.1016/0010-2180(73)90006-0.\n- Weiw, Edward D.; Levchik, Sergei V. (4 June 2009). Fwame retardants for pwastics and textiwes: Practicaw appwications. pp. 15–16. ISBN 978-3-446-41652-9.\n- Kiehne, Heinz Awbert (2003). \"Types of Awwoys\". Battery Technowogy Handbook. CRC Press. pp. 60–61. ISBN 978-0-8247-4249-2.\n- Wiwwiams, Robert S. (2007). Principwes of Metawwography. Read books. pp. 46–47. ISBN 978-1-4067-4671-6.\n- Howmyard, E. J. (2008). Inorganic Chemistry – A Textbook for Cowweges and Schoows. Read Books. pp. 399–400. ISBN 978-1-4437-2253-7.\n- Ipser, H.; Fwandorfer, H.; Luef, Ch.; Schmetterer, C.; Saeed, U. (2007). \"Thermodynamics and phase diagrams of wead-free sowder materiaws\". Journaw of Materiaws Science: Materiaws in Ewectronics. 18 (1–3): 3–17. doi:10.1007/s10854-006-9009-3.\n- Huww, Charwes (1992). Pewter. Osprey Pubwishing. pp. 1–5. ISBN 978-0-7478-0152-8.\n- De Jong, Bernard H. W. S.; Beerkens, Ruud G. C.; Van Nijnatten, Peter A. (2000). \"Gwass\". Uwwmann's Encycwopedia of Industriaw Chemistry. doi:10.1002/14356007.a12_365. ISBN 978-3-527-30673-2.\n- Yamashita, H.; Yamaguchi, S.; Nishimura, R.; Maekawa, T. (2001). \"Vowtammetric Studies of Antimony Ions in Soda-wime-siwica Gwass Mewts up to 1873 K\" (PDF). Anawyticaw Sciences. 17 (1): 45–50. doi:10.2116/anawsci.17.45. PMID 11993676.\n- O'Mara, Wiwwiam C.; Herring, Robert B.; Hunt, Lee Phiwip (1990). Handbook of semiconductor siwicon technowogy. Wiwwiam Andrew. p. 473. ISBN 978-0-8155-1237-0.\n- Maiti, C. K. (2008). Sewected Works of Professor Herbert Kroemer. Worwd Scientific, 2008. p. 101. ISBN 978-981-270-901-1.\n- Committee On New Sensor Technowogies: Materiaws And Appwications, Nationaw Research Counciw (U.S.) (1995). Expanding de vision of sensor materiaws. p. 68. ISBN 978-0-309-05175-0.\n- Kinch, Michaew A (2007). Fundamentaws of infrared detector materiaws. p. 35. ISBN 978-0-8194-6731-7.\n- Wiwwardson, Robert K & Beer, Awbert C (1970). Infrared detectors. p. 15. ISBN 978-0-12-752105-3.\n- Russeww, Cowin A. (2000). \"Antimony's Curious History\". Notes and Records of de Royaw Society of London. 54 (1): 115–116. doi:10.1098/rsnr.2000.0101. JSTOR 532063. PMC 1064207.\n- Harder, A. (2002). \"Chemoderapeutic approaches to schistosomes: Current knowwedge and outwook\". Parasitowogy Research. 88 (5): 395–7. doi:10.1007/s00436-001-0588-x. PMID 12049454.\n- Kassirsky, I. A.; Pwotnikov, N. N. (1 August 2003). Diseases of Warm Lands: A Cwinicaw Manuaw. pp. 262–265. ISBN 978-1-4102-0789-0.\n- Organisation Mondiawe de wa Santé (1995). Drugs used in parasitic diseases. pp. 19–21. ISBN 978-92-4-140104-3.\n- McCawwum, R. I. (1999). Antimony in medicaw history: an account of de medicaw uses of antimony and its compounds since earwy times to de present. Pentwand Press. ISBN 978-1-85821-642-3.\n- Nationaw Research Counciw (1970). Trends in usage of antimony: report. Nationaw Academies. p. 50.\n- Stewwman, Jeanne Mager (1998). Encycwopaedia of Occupationaw Heawf and Safety: Chemicaw, industries and occupations. p. 109. ISBN 978-92-2-109816-4.\n- Jang, H & Kim, S. (2000). \"The effects of antimony trisuwfide Sb S and zirconium siwicate in de automotive brake friction materiaw on friction\". Journaw of Wear. 239 (2): 229. doi:10.1016/s0043-1648(00)00314-8.\n- Randich, Erik; Duerfewdt, Wayne; McLendon, Wade; Tobin, Wiwwiam (2002). \"A metawwurgicaw review of de interpretation of buwwet wead compositionaw anawysis\". Forensic Science Internationaw. 127 (3): 174–91. doi:10.1016/S0379-0738(02)00118-4. PMID 12175947.\n- Lawovic, M.; Werwe, H. (1970). \"The energy distribution of antimonyberywwium photoneutrons\". Journaw of Nucwear Energy. 24 (3): 123. Bibcode:1970JNuE...24..123L. doi:10.1016/0022-3107(70)90058-4.\n- Ahmed, Syed Naeem (2007). Physics and engineering of radiation detection. p. 51. ISBN 978-0-12-045581-2.\n- Schmitt, H (1960). \"Determination of de energy of antimony-berywwium photoneutrons\". Nucwear Physics. 20: 220. Bibcode:1960NucPh..20..220S. doi:10.1016/0029-5582(60)90171-1.\n- NIOSH Pocket Guide to Chemicaw Hazards. \"#0036\". Nationaw Institute for Occupationaw Safety and Heawf (NIOSH).\n- Wakayama, Hiroshi (2003) \"Revision of Drinking Water Standards in Japan\", Ministry of Heawf, Labor and Wewfare (Japan); Tabwe 2, p. 84\n- Shotyk, W.; Krachwer, M.; Chen, B. (2006). \"Contamination of Canadian and European bottwed waters wif antimony from PET containers\". Journaw of Environmentaw Monitoring. 8 (2): 288–92. doi:10.1039/b517844b. PMID 16470261.\n- Guidewines for Drinking-water Quawity (PDF) (4f ed.). Worwd Heawf Organization, uh-hah-hah-hah. 2011. p. 314. ISBN 978-92-4-154815-1.\n- \"Antimony poisoning\". Encycwopedia Britannica.\n- Sundar, S; Chakravarty, J (2010). \"Antimony Toxicity\". Internationaw Journaw of Environmentaw Research and Pubwic Heawf. 7 (12): 4267–4277. doi:10.3390/ijerph7124267. PMC 3037053. PMID 21318007.\n- Endwich, F. M. (1888). \"On Some Interesting Derivations of Mineraw Names\". The American Naturawist. 22 (253): 21–32 . doi:10.1086/274630. JSTOR 2451020.\n- Edmund Oscar von Lippmann (1919) Entstehung und Ausbreitung der Awchemie, teiw 1. Berwin: Juwius Springer (in German).\n- Pubwic Heawf Statement for Antimony\n|Wikimedia Commons has media rewated to Antimony.|\n|Look up antimony in Wiktionary, de free dictionary.|", "domain": "chemistry", "round": 3} +{"url": "http://escholarship.lib.okayama-u.ac.jp/en/journal/fest/12/1/article/11450", "date": "2021-03-07T16:24:33Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-10/segments/1614178377821.94/warc/CC-MAIN-20210307135518-20210307165518-00102.warc.gz", "language_score": 0.8985233306884766, "token_count": 399, "dump": "CC-MAIN-2021-10", "global_id": "webtext-fineweb__CC-MAIN-2021-10__0__114443413", "lang": "en", "text": "As a rule, ion uptake by plant cells and roots has features of saturation kinetics. This is in accordance with the assumption of control, as for example by the number of binding sites of ions (carriers, permeases), or the capacity of the proton efflux pumps, in the plasma membrane and tonoplast. Solute transport across membranes is carrier mediated transport. Protein macromolecules integrated into the membrane matrix seems to be the carriers. The carrier-mediated process is subject to kinetics assumig that the number of carriers (binding sites) in the membranes is limited. Kinetics of ion transport through a membrane is considered equivalent to relationship between an enzyme and its substrate. To obtain plants of different P status, two genetically diverse Brassica cultivars (P-tolerant 'Con-1' and P-sensitive 'Gold Rush') were grown for several weeks in nutrient solution culture media. P-uptake kinetics of the roots with intact plants in short-term experiments by monitoring P depletion in culture media revealed that P-tolerant 'Con-1' cultivar had favorable characteristics for P-uptake because of high I(max) or V(max) and low K(m) or 1/2 I(max) value than P-sensitive 'Gold Rush' cultivar. By plotting relative growth rate (RGR) and internal P-concentration (PNC) among P-tolerant (group I; Brown Raya, Con-1, Rainbow, Dunkled and Peela Raya) and P-sensitive (group II; Toria, Sultan Raya, B.S.A, Toria Selection and Gold Rush) cultivars revealed that group I cultivars showed large metabolic fraction and small structural fraction than group II cultivars which provided basis for P-stress tolerance.\nMembrane binding sites\nI(max) or V(max), K(m) Pi-uptake rate", "domain": "chemistry", "round": 3} +{"url": "https://www.omicsonline.org/proceedings/bioactive-food-components-and-metabolic-syndrome-6399.html", "date": "2021-06-17T07:04:33Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-25/segments/1623487629209.28/warc/CC-MAIN-20210617041347-20210617071347-00120.warc.gz", "language_score": 0.8913168907165527, "token_count": 544, "dump": "CC-MAIN-2021-25", "global_id": "webtext-fineweb__CC-MAIN-2021-25__0__49972448", "lang": "en", "text": "Bioactive Food Components And Metabolic Syndrome | 6399\nJournal of Obesity & Weight Loss Therapy\nOur Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.\nThe rapid increase in prevalence of metabolic syndrome, which is associated with a state of elevated systemic oxidative stress,\nis projected to cause future increases in the prevalence of diabetes and cardiovascular diseases. Oxidation of polyunsaturated\nfatty acids and sugars produces reactive carbonyl species, which, due to their electrophilic nature, react with nucleophilic sites\nof certain amino acids leading to formation of protein adducts such as advanced glycation/lipoxidation end products (AGEs/\nAGEs) resulted in cellular dysfunction. Therefore, an effective reactive carbonyl species and AGEs/ALEs sequestering agent can\nprevent such cellular dysfunction. We have demonstrated that the dietary histidine-dipeptides are effective sequester of cytotoxic\ncarbonyls and prevent various metabolic risk factors in animal model. In addition, bioactive components in plant foods such as\ncarotenoids, tocopherols and oryzanols have been continuously studied for their biological functions against oxidative damage\nand progression of metabolic syndrome in our laboratory. Identification and characterization of bioactive components in plant\nfoods using state-of-the-art techniques will be introduced. Further, dietary defense strategies against progression of metabolic\nsyndrome utilizing these bioactive food components and their action mechanisms will be discussed.\n[Supported in part by USDA 1950-51000-065-08S, USA and Rural Development Administration PJ008755, Republic of Korea]\nKyung-Jin Yeum, Ph.D. is a Scientist at the Jean Mayer USDA-Human Nutrition Research Center on Aging and Associate Professor at the Friedman\nSchool of Nutrition Science and Policy at Tufts University, a collaborative Professor at Faculdade de Medicina de Botucatu/UNESP in Brazil. Dr.\nYeum has been conducting various\n, animal and human studies to determine action mechanisms of bioactive food components against\noxidative stress in humans. Her research efforts have produced more than 50 peer-reviewed articles in this area. Dr. Yeum is a member of various\nprofessional societies such as the American Society for Nutrition and International Carotenoid Society.\nPeer Reviewed Journals\nMake the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals", "domain": "chemistry", "round": 3} +{"url": "https://www.bagpipechina.com/25-liters-cubitainer-with-wide-spout.html", "date": "2021-04-14T19:56:39Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-17/segments/1618038078021.18/warc/CC-MAIN-20210414185709-20210414215709-00296.warc.gz", "language_score": 0.6803818941116333, "token_count": 1182, "dump": "CC-MAIN-2021-17", "global_id": "webtext-fineweb__CC-MAIN-2021-17__0__235611744", "lang": "en", "text": "Title: 25 Liters 6.25 gallon collapsible LDPE cubitainer with wide spout\nKeyword: 108mm spout cubitainer,6.25 gallon cubitainer,25 litre LDPE cubitainer,\n25 Liters LDPE Cubitainers are made of low-density flexible polyethylene(LDPE) cube-shaped inserts inside a heavy-duty corrugated outer carton.These inner LDPE flexible cubitainers nest uniformly when empty and expand readily when filled with liquid.Easy to ship,handle and pour.Designed to collapse as product is dispensed.The non-glug design assures product flow in a continuous,uninterrupted stream.A reversible well design permits opening to be raised or depressed for pouring and storage.\nCubitainers include 108-mm caps with injection-molded threads.\nCOLLAPSIBLE SHAPED CONTAINER,LDPE,6.25 GALLON,WITH 108mm SCREW CAP\nModel Number: CFD-CUB0025\nMaterial: Low-density polyethylene (LDPE)\nCapacity (Liters/gallon): 25 Litres,6.25 Gallon\nCHNTAINER® cubitainer are the preferred container when background particle count matters.\nLesser containers can affect readings of instruments or even a patient's diagnosis,but our clients rest assured knowing that CFD delivers consistently high performance containers.\nOur resin is carefully sourced and manufactured entirely in-house for total quality control in a clean environment.\nOur clients conduct independent background count tests for each lot of CHNTAINER® cubitainer, which is why we are often referred to as the 'gold standard' for resin cleanliness.\nCHNTAINER® cubitainer are stocked in 4,5,10,15,18,20,25 liter sizes and are easily customizable to meet your space requirements easily and efficiently.\nCHNTAINER® cubitainer Key Advantages\nAdvanced packaging cleanliness\nCompletely manufactured in-house for total quality control\nExpertise in the medical and pharmaceutical industries in a variety of applications\nMaximizes storage space\nRugged, yet flexible standalone container\nEasy to handle\nShip and store huge space savings\nRelated other type of CHNTAINER® cubitainers :\n1 Liter 1quart cubitainer, 2 Liter 2 quart cubitainer, 3 Liter 0.75 Gallon cubitainer, 5 Liters LDPE cubitainer,\n2.5 gallon 10 Litres LDPE cubitainer,3 gallon 15 Litres cubitainer,18L cubitainer,5 gallon 20 litres cubitainers,25 L cubitainers;\nhematology reagent cubitainer,diagnostic reagent cubitainer,ultrasound gel cubitainer,water cubitainer,bunker sampling cubitainer,\nInk cubitainer,paint cubitainer,water-based coatings cubitainer,adhesive glue cubitainers,detergent cubitainer,liquid fertilizers cubitainer,pure water cubitainer,ISE buffer cubitainer,cleaner cubitainer, Photocatalytic Paint Tio2 cubitainer,vented cubitainer,rice wine cubitainer,sake cubitainer,mirin cubitainer 18L,AdBlue cubitainer,Organic enzyme Lactic Acid bacteria cubitainer,Bamboo Vinegar Solution cubitainer,Bamboo vinegarcubitainer,Dutch Formula Bloom cubitainer,The plant-activating agent cubitainer,Wood vinegar cubitainer,Organic enzymes cubitainer;ISE buffer cubitainer,lyse cubitainer,diluent cubitainer\nApplication of the CHNTAINER® cubitainers 18L:\nSuch as thin-walled square barrels,collapsible squash,soft plastic barrels to use,portable,easy storage and transportation.But it should not separate containers used for packaging,should be accompanied by packing.Can be used for packaging must have flooded corrosive liquid and food stains.\nFor example:salty cucumber,salty eggplant,red pepper,bracken,water celery,basil,do yellow pepper,crisp appetizer,appetizers Yang ginger,etc.Labadou.Salted Bracken,mountain celery,Waterloo son mushrooms,Osmunda do,export products have salted fresh bamboo, mushroom,mountain vegetables,demi-glace bonus,demi-glace pear,persimmon demi-glace,demi-glace and dried mulberry,water fluffy snow boiled,poached mushrooms,boiled mushrooms,boiled Pleurotus ostreatus,dehydration Gong vegetables,dehydrated onion,dehydrated green onion,dehydrated vegetables dehydrated vegetables,dehydrated carrots,salted large root,salinization Mosla head,salinization of Artemisia vegetables,salted eggplant Medium,salinization Shan Lu,Salted Pleurotus cornucopiae,snow and dried salted,salted lotus root,burdock saline,saline mushrooms,persimmon leaf salinity,salinization of bamboo leaves,salinization four melon leaf,salinization thin bamboo shoots,carrots salinity,salinization Pleurotus ostreatus, konjac,fresh mushrooms,fresh Brasenia schreberi fresh yellow onions,fresh burdock,fresh carrots,fresh taro fresh lotus root", "domain": "chemistry", "round": 3} +{"url": "https://www.business.qld.gov.au/industries/farms-fishing-forestry/agriculture/disaster/flood/during/animal-welfare/clean", "date": "2023-12-10T10:56:49Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679101779.95/warc/CC-MAIN-20231210092457-20231210122457-00138.warc.gz", "language_score": 0.9142929911613464, "token_count": 558, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__240051480", "lang": "en", "text": "Disinfecting animal living areas after flood damage\nBefore giving your animals access to any kennels or living areas, properly disinfect the area to protect your animals from potential sources of contamination.\nIf floodwater has inundated the living area, try to keep animals away until you can effectively clean it because it may have high levels of contamination due to floodwater mixing with sewage and other material.\nDo not allow your animals to drink any remaining floodwater, or eat any carcasses or debris lying on the ground. If necessary, fence off an area that is safe to hold the animals until you have cleaned any contaminated areas.\nDisinfecting contaminated surfaces\nIt is important that you effectively disinfect any surfaces that have come into contact with floodwater. To do this, first remove loose dirt and debris from surfaces by thoroughly cleaning with detergent. A pressure washer, if available, can help remove stubborn areas of mud.\nYou can buy commercial-grade products from your local hardware store or agricultural supplier that contain compounds designed to clean, disinfect and sanitise buildings and surrounding areas. For disinfectant to be effective, you must leave the surface wet and use the required dilution rate for the required contact time.\nAlternatively, washing down all surfaces with a suitable household-grade disinfectant solution can be an effective disinfectant. Most bleaches also act as disinfectants, so check that the product you use is a registered disinfectant. The solution helps prevent the spread of infection by killing common bacteria and viruses that could make your animals sick.\nAfter removing loose dirt and debris from surfaces, scrub the area with the bleach solution. Keep the surfaces wet for the required contact time and then rinse off. Ensure that the area is thoroughly dry before allowing your animal into the area.\nNote: organic matter, such as dung, hair and plant material, will inactivate the disinfectant effects of chlorine compounds.\nEnsure that you use a registered product and follow the manufacturer's directions, including dilution rates, contact time and safety precautions as listed on the product label. Do not mix chlorine and ammonium compounds. Follow the recommended application safety precautions outlined on the label.\nDisinfecting bedding and containers\nIf bedding or food and water containers have been contaminated, thoroughly clean and disinfect them before use. You can usually clean metal and hard plastics effectively, though timber products can be more difficult to disinfect.\nYou should use a suitable commercial- or household-grade disinfectant. Note that the dilution rate may be different to the recommendation for disinfecting hard surfaces.\nAlways follow the manufacturer's dilution recommendations listed on the product label.\nIf you are unsure whether you can disinfect some items effectively, safely dispose of those items and purchase new ones.", "domain": "chemistry", "round": 3} +{"url": "https://www.epigentek.com/catalog/set1-polyclonal-antibody-p-264.html", "date": "2019-10-19T12:59:42Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-43/segments/1570986693979.65/warc/CC-MAIN-20191019114429-20191019141929-00286.warc.gz", "language_score": 0.8276970982551575, "token_count": 334, "dump": "CC-MAIN-2019-43", "global_id": "webtext-fineweb__CC-MAIN-2019-43__0__79377897", "lang": "en", "text": "The Set1/COMPASS histone methyltransferase complex contains the SET1 histone methyltransferase protein. It functions as a transcriptional co-activator and methylates histone H3 at Lys4 (H3K4). Although first identified in yeast, SET1-related proteins are also found within mammals, including proteins SET1A, SET1B, MLL1, MLL2, MLL3, and MLL4. These proteins work together in a complex to methylate histone H3 at Lys4. In addition, SET1/COMPASS histone methyltransferase complexes are thought to play a role in leukemogenesis due to a significant amount of hematological malignancies containing MLL translocations.\nSET1 Polyclonal Antibody. Unconjugated. Raised in: Rabbit.\nLiquid. 0.03% Proclin 300. 50% Glycerol, 0.01M PBS, pH 7.4.\nProtein G purified\nRecombinant Human Histone-lysine N-methyltransferase SETD1A protein (188-304AA)\nShipped at 4°C. Aliquot store at -20°C . Avoid repeated freeze / thaw cycles.\nHistone-lysine N-methyltransferase SETD1A antibody, hSET1A antibody, KMT2F antibody, Lysine N methyltransferase 2F antibody, SET domain containing protein 1A antibody, Set1 Ash2 histone methyltransferase complex subunit SET1 antibody, SET1A antibody, SETD1A antibody", "domain": "chemistry", "round": 3} +{"url": "https://www.nmn.com/news/brian-dysfunctions-in-alzheimers-disease-decreased-linked-to-lower-nad-and-nmn-production-by-nampt-in-app-ps1-mice", "date": "2024-02-28T07:12:44Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707947474697.2/warc/CC-MAIN-20240228044414-20240228074414-00766.warc.gz", "language_score": 0.9366363286972046, "token_count": 1556, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__36356469", "lang": "en", "text": "Recent research on Alzheimers Disease from the Shanghai Geriatric Institute of Chinese Medicine and Shanghai University of Traditional Chinese Medicine identified Nicotinamide Mononucleotide (NMN) synthesis as a principal step in disease progression.\nResearch on Alzheimers Disease from the Shanghai Geriatric Institute of Chinese Medicine and Shanghai University of Traditional Chinese Medicine identified nicotinamide mononucleotide (NMN) synthesis as a principal step in disease progression. NMN is the number one precursor used to make an important coenzyme in the body, Nicotinamide Adenine Dinucleotide (NAD). NAD+ is a predominant co-enzyme for hundreds of metabolic reactions 3.\nDavid Sinclair, Harvard professor, notably conveyed “You could argue NAD+ is the most important molecule in the body, maybe with the exception of ATP. But without either of them, you’re dead in about 30 seconds.” 2\nNAD+ decreases during metabolic stress and aging. Low levels of NAD+ are seen alongside Alzheimer’s disease and conditions linked to Alzheimer’s disease such as heart and vascular diseases and Type 2 diabetes. NAD+ benefits vascular health and metabolism, increasing vasodilation, blood flow to the brain, and cognitive function 4,5. NAD+’s metabolism is especially important as “ Studies have shown that energy dysmetabolism contributes significantly to the pathogenesis of a variety of aging-associated diseases and degenerative diseases of the nervous system, including Alzheimer’s Disease (AD)” 1. NAD+’s production is limited by the availability of NMN and the activity of nicotinamide phosphoribosyltransferase (NAMPT), the enzyme responsible for producing NMN.\nNAMPT is responsible for producing the NAD+ precursor, NMN, and is the rate-limiting step for NAD production. The research team found that NAMPT inhibition causes Alzheimer’s disease metrics to intensify. Meanwhile, NAD+ injections decrease key indicators of Alzheimer’s disease, resulting in ‘positive feedback’ for NAMPT expression. This means that giving the mice NAD+ increases the ability to make more NAD+. The team found that NAD+ upregulates NAMPT expression in the cells which affected energy metabolism, plaque formation and cognitive decline in transgenic mice.\nThe team used transgenic mice, with human disease-genes. These mice, from Nanjing University, had Human DNA for Amyloid Precursor Protein (APP) and human presenilin protein (PS1). This allows the mice to secrete human Amyloid-Beta peptides. These proteins aggregate, forming plaques in Alzheimer’s disease that cause brain cells to die 6. Similar mice have been used around the world in other experiments of behavioral and physical changes that occur in Alzheimer’s disease.\nThe team theorized that re-establishing regular metabolism would limit brain-cell death caused by plaque formation, slowing the progress of Alzheimer’s disease. To test this claim a variety of examinations were done on four groups of mice. Normal mice, Mice with human APP and PS1 genes (Alzheimer disease mice), disease mice in the test group were given a NAMPT inhibitor (FJ866) , and disease mice were given NAD+ intraperitoneally.\nTo test the role of NAMPT, the researchers injected the Alzheimer’s Diseased mice with NAD+ (30 mg/kg) or NAMPT inhibitors (1mg/kg) at 20 weeks of age and once every other day for 4 weeks. NMN inhibitor halted NMN and NAD+ production. NAD+ was used to simulate well functioning NAMPT. The researchers then ran a litany of tests to examine how the mice responded to either treatment. The team tested spatial reasoning skills, energy production, relative NAD+ concentration, and protein plaque formation.\nThe team tested the spatial memory of the mice with a morris water maze. They found that disease mice were significantly worse at the maze than the control group, indicating impaired mental abilities. Disease mice given NAD+ injections spent more time in the target quadrant, indicating that they could more easily remember how to complete the maze than their peers.\nThe team tested the mice for ‘senile plaques’ in the hippocampus and cortex, areas of the brain associated with memory, learning and reasoning. The researches stained slivers of brain tissue with Thioflavin S. They found that, as expected, senile plaques formed in the Alzheimer’s disease mice. The control group had the least amount of protein ‘buildup’. The Alzheimer’s disease mice had the most amount of plaque build up, followed by mice given the NAMPT inhibitor. The Alzheimr’s disease mice with NAD+ treatment had less protein plaques than Alzheimer’s mice but more than normal control-group mice.\nThe team tested differences in energy metabolism by measuring the amount of Adenosine Triphosphate (ATP) in the brains of various mice. The team found that mice with Alzheimer’s disease and NAMPT dysfunction had significantly less energy in the brain (less ATP). Furthermore, they found that giving NAD+ injections significantly restored most of the energy as ATP in the brain (P<0.05).they found that the Control group had the most amount of energy in the brain. Alzheimer’s disease mice and mice with NAMPT inhibition had significantly reduced energy in the brain.\nThe team tested the brains for relative concentrations of NAD+. They found that mice with Alzheimer’s disease have a smaller ratio of NAD+ to NADH in their brains. Disease mice were given NAD+ injections, however had increased amounts of NAD+ in the brain similar to the control mice.\nThe team compared the expression of NAMPT protein in the brains and found that the mice with Alzheimer’s disease had significantly less NAMPT production than the control group (P<0.05). Furthermore, the NAD+ injections significantly boosted NAMPT production compared to the disease group (P<0.05). This means that giving NAD+ as a supplement boosted production of the NAMPT enzyme, the limiting ingredient to NAD+ production. This would suggest that providing NAD+ creates a positive feedback look that results in increased NAD+ production.\nLastly, the team performed a ‘western blot’ to analyze the exact quantity of disease-causing protein that was produced in the various group. The team extracted proteins from the brain and found that “ injecting NAD+ increased the expression of NAMPT in the cortex in the NAD+ mice (P<0.05).” The diseased mice had decreased SIRT1, and NAMPT production, which was somewhat relieved by giving NAD+ to the disease mice.\nThe team found that diseased mice with NAD+ had increased cognitive function, increased energy production (ATP), younger NAD+ profiles (higher NAD+/NADH), and decreased plaque formation. This means that diseased mice given NAD+ supplements had fewer indications of Alzheimer’s disease. The shanghai team showed that Alzheimer’s disease bio-metrics improved after treatment with NAD+. It would be interesting if a future study increased the sample size to verify the impact of NAMPT inhibition on Alzheimer’s disease mice. Furthermore, it would be useful to repeat this experiment using NMN instead of NAD+, given that NMN is the product of NAMPT synthesis rather than NAD+.", "domain": "chemistry", "round": 3} +{"url": "https://www.basg.gv.at/en/market-surveillance/official-announcements/detail/fasturtec", "date": "2023-09-27T21:44:00Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233510326.82/warc/CC-MAIN-20230927203115-20230927233115-00274.warc.gz", "language_score": 0.6862261295318604, "token_count": 309, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__66007805", "lang": "en", "text": "Fasturtec 1,5 mg Pulver und Lösungsmittel zur Herstellung eines Infusionslösungskonzentrats\nThe marketing authorisation holder informed its customers by August 27, 2020 that stability studies have shown a deviation in rasburicase enzyme activity affecting the US market. However, based on the investigations, it is assumed that this deviation was caused by a non-conforming filling volume of the vials. A low filling volume may lead to a potential lack of efficacy. Therefore all batches that might be affected will be recalled as a precautionary measure. In Austria batch number A9306 is affected by the recall.\n|Name of the medicinal product||Fasturtec 1,5mg/ml Pulver und Lösungsmittel zur Herstellung eines Infusionslösungskonzentrats|\n|Marketing authorisation number(s)||EU/1/00/170/002|\n|Marketing authorisation holder||sanofi-aventis groupe|\n|Classification of the recall||2|\n|Depth of recall||Pharmacies|\n|BASG reference number||INS-640.001-3287|", "domain": "chemistry", "round": 3} +{"url": "https://www.mdpi.com/1996-1944/9/6/414", "date": "2020-01-23T09:58:42Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-05/segments/1579250609478.50/warc/CC-MAIN-20200123071220-20200123100220-00116.warc.gz", "language_score": 0.9252517223358154, "token_count": 392, "dump": "CC-MAIN-2020-05", "global_id": "webtext-fineweb__CC-MAIN-2020-05__0__1958171", "lang": "en", "text": "Root caries prevention has been a challenge for clinicians due to its special anatomical location, which favors the accumulation of dental plaque. Researchers are looking for anti-biofouling material to inhibit bacterial growth on exposed root surfaces. This study aimed to develop polydopamine-induced-polyethylene glycol (PEG) and to study its anti-biofouling effect against a multi-species cariogenic biofilm on the root dentine surface. Hydroxyapatite disks and human dentine blocks were divided into four groups for experiments. They received polydopamine-induced-PEG, PEG, polydopamine, or water application. Contact angle, quartz crystal microbalance, and Fourier transform infrared spectroscopy were used to study the wetting property, surface affinity, and an infrared spectrum; the results indicated that PEG was induced by polydopamine onto a hydroxyapatite disk. Salivary mucin absorption on hydroxyapatite disks with polydopamine-induced-PEG was confirmed using spectrophotometry. The growth of a multi-species cariogenic biofilm on dentine blocks with polydopamine-induced-PEG was assessed and monitored by colony-forming units, confocal laser scanning microscopy, and scanning electron microscopy. The results showed that dentine with polydopamine-induced-PEG had fewer bacteria than other groups. In conclusion, a novel polydopamine-induced-PEG coating was developed. Its anti-biofouling effect inhibited salivary mucin absorption and cariogenic biofilm formation on dentine surface and thus may be used for the prevention of root dentine caries.\nThis is an open access article distributed under the Creative Commons Attribution License\nwhich permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited", "domain": "chemistry", "round": 3} +{"url": "https://www.gainhealth.org/resources/reports-and-publications/fortifying-complementary-foods-nafeedta-considerations", "date": "2021-01-20T19:34:34Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-04/segments/1610703521987.71/warc/CC-MAIN-20210120182259-20210120212259-00010.warc.gz", "language_score": 0.9402294754981995, "token_count": 430, "dump": "CC-MAIN-2021-04", "global_id": "webtext-fineweb__CC-MAIN-2021-04__0__282590398", "lang": "en", "text": "As a highly bioavailable iron compound, sodium iron (iii) ethylenediaminetetraacetate (NaFeEDTA) has been recommended as a food additive for fortification. The amount of a food additive that can be ingested daily over a lifetime without appreciable health risk is termed the acceptable daily intake (ADI). The ADI for NaFeEDTA is based on body weight. For complementary foods and food supplements for infants and young children in low‐income countries, where prevalence of underweight is high yet nutrient needs are also high, it is not clear which doses might be appropriate. The objective is to calculate the dosage of NaFeEDTA for fortifying complementary foods assuming different population prevalences of underweight.\nMathematical models were used to simulate the dosage of NaFeEDTA for 6‐ to 8‐month‐old infants under different prevalences of underweight ranging from 5% to 40%. In order to keep NaFeEDTA intake below the ADI for ethylenediaminetetraacetate (EDTA) recommended by the Joint Food and Agriculture Organization (FAO)/World Health Organization (WHO) Expert Committee on Food Additives for 95% of 6‐ to 8‐month‐old infants, the daily iron dose from NaFeEDTA in fortified complementary foods should be set between 2.2 mg and 1.8 mg in countries with a prevalence of underweight among 6‐ to 8‐month‐old infants between 5% and 40%, respectively. If 2 mg of iron is given to all 6‐ to 8‐month‐old infants, the percentage exceeding the ADI for EDTA would be <10% for populations with <30% of children who are underweight, which is the case for many countries. In conclusion, 2 mg of iron from NaFeEDTA could be used for fortifying one daily serving of complementary food to ensure EDTA levels are below the ADI for infants 6–8 months of age. An additional source of iron (such as ferrous sulfate) should be included to increase the iron dose to desired fortification levels.", "domain": "chemistry", "round": 3} +{"url": "https://medicine.duke.edu/faculty/ivan-spasojevic-phd?page=4", "date": "2021-05-06T07:42:07Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-21/segments/1620243988741.20/warc/CC-MAIN-20210506053729-20210506083729-00161.warc.gz", "language_score": 0.6704926490783691, "token_count": 896, "dump": "CC-MAIN-2021-21", "global_id": "webtext-fineweb__CC-MAIN-2021-21__0__34784506", "lang": "en", "text": "Education and Training\n- Ph.D., Duke University, 1999\nTovmasyan, Artak, Sebastian Carballal, Robert Ghazaryan, Lida Melikyan, Tin Weitner, Clarissa G. C. Maia, Julio S. Reboucas, et al. “Rational Design of New Cationic Mn Porphyrins and Evaluation of Their Therapeutic Potential.” Free Radical Biology and Medicine 76 (November 2014): S94–S94. https://doi.org/10.1016/j.freeradbiomed.2014.10.326.\nReitman, Zachary J., Christopher G. Duncan, Ethan Poteet, Ali Winters, Liang-Jun Yan, David M. Gooden, Ivan Spasojevic, Laszlo G. Boros, Shao-Hua Yang, and Hai Yan. “Cancer-associated isocitrate dehydrogenase 1 (IDH1) R132H mutation and d-2-hydroxyglutarate stimulate glutamine metabolism under hypoxia.” J Biol Chem 289, no. 34 (August 22, 2014): 23318–28. https://doi.org/10.1074/jbc.M114.575183.\nJumbo-Lucioni, Patricia P., Emily L. Ryan, Marquise L. Hopson, Heather M. Bishop, Tin Weitner, Artak Tovmasyan, Ivan Spasojevic, et al. “Manganese-based superoxide dismutase mimics modify both acute and long-term outcome severity in a Drosophila melanogaster model of classic galactosemia.” Antioxid Redox Signal 20, no. 15 (May 20, 2014): 2361–71. https://doi.org/10.1089/ars.2012.5122.\nBatinic-Haberle, Ines, Artak Tovmasyan, Emily R. H. Roberts, Zeljko Vujaskovic, Kam W. Leong, and Ivan Spasojevic. “SOD therapeutics: latest insights into their structure-activity relationships and impact on the cellular redox-based signaling pathways.” Antioxid Redox Signal 20, no. 15 (May 20, 2014): 2372–2415. https://doi.org/10.1089/ars.2012.5147.\nLi, Alice Ma, Jake Martins, Artak Tovmasyan, Joan S. Valentine, Ines Batinic-Haberle, Ivan Spasojevic, and Edith B. Gralla. “Differential localization and potency of manganese porphyrin superoxide dismutase-mimicking compounds in Saccharomyces cerevisiae.” Redox Biology 3 (January 1, 2014): 1–6. https://doi.org/10.1016/j.redox.2014.0.003.\nLi, Alice Ma, Jake Martins, Artak Tovmasyan, Joan S. Valentine, Ines Batinic-Haberle, Ivan Spasojevic, and Edith B. Gralla. “Differential localization and potency of manganese porphyrin superoxide dismutase-mimicking compounds in Saccharomyces cerevisiae.” Redox Biol 3 (2014): 1–6. https://doi.org/10.1016/j.redox.2014.09.003.\nTovmasyan, Artak, Tin Weitner, Huaxin Sheng, MiaoMiao Lu, Zrinka Rajic, David S. Warner, Ivan Spasojevic, Julio S. Reboucas, Ludmil Benov, and Ines Batinic-Haberle. “Differential coordination demands in Fe versus Mn water-soluble cationic metalloporphyrins translate into remarkably different aqueous redox chemistry and biology.” Inorg Chem 52, no. 10 (May 20, 2013): 5677–91. https://doi.org/10.1021/ic3012519.", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/znf503-antibody-ab69689.html", "date": "2019-12-07T03:53:50Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-51/segments/1575540495263.57/warc/CC-MAIN-20191207032404-20191207060404-00477.warc.gz", "language_score": 0.6634874939918518, "token_count": 430, "dump": "CC-MAIN-2019-51", "global_id": "webtext-fineweb__CC-MAIN-2019-51__0__68909113", "lang": "en", "text": "Product nameAnti-ZNF503 antibody\nSee all ZNF503 primary antibodies\nDescriptionMouse polyclonal to ZNF503\nTested applicationsSuitable for: WBmore details\nSpecies reactivityReacts with: Human\nZNF503 (NP_116161, 1 a.a. ~ 646 a.a) human protein.\n- ZNF503 transfected 293T lysate.\nStorage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.\nStorage bufferpH: 7.20\nConstituent: 2.68% PBS\nConcentration information loading...\nPurityProtein A purified\nOur Abpromise guarantee covers the use of ab69689 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\n|WB||1/500 - 1/1000. Detects a band of approximately 75 kDa (predicted molecular weight: 63 kDa).|\nFunctionMay function as a transcriptional repressor.\nSequence similaritiesBelongs to the Elbow/Noc family.\nContains 1 C2H2-type zinc finger.\n- Information by UniProt\n- FLJ45745 antibody\n- MGC2555 antibody\n- NOLZ 1 antibody\nAll lanes : Anti-ZNF503 antibody (ab69689) at 1/500 dilution\nLane 1 : ZNF503 transfected 293T lysate\nLane 2 : Non-transfected 293T lysate\nLysates/proteins at 25 µg per lane.\nAll lanes : Goat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilution\nPredicted band size: 63 kDa\nObserved band size: 75 kDa why is the actual band size different from the predicted?\nab69689 has not yet been referenced specifically in any publications.", "domain": "chemistry", "round": 3} +{"url": "https://magicecommerce.com/slides/slide/taski-r1-msds-8", "date": "2023-02-01T12:52:20Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-06/segments/1674764499934.48/warc/CC-MAIN-20230201112816-20230201142816-00099.warc.gz", "language_score": 0.7000138163566589, "token_count": 979, "dump": "CC-MAIN-2023-06", "global_id": "webtext-fineweb__CC-MAIN-2023-06__0__259633901", "lang": "en", "text": "1. Date: 23/07/2007 Revision No: 1 Page 1 of 2 SAFETY DATA SHEET 1. IDENTIFICATION OF THE SUBSTANCE / PREPARATION AND O F THE COMPANY / UNDERTAKING Diversey E astern and Central A frica Limited Kaptagat Road, Loresho PO Box 41939, 00100 GPO Nair obi Tel +254 20 4224000 Fax +254 20 4224888 TASKI R1 PLUS Clearance Code Professional Cleaning /Maintenance Product For Building Care Product Code DL10875 MSDS 4774 2. COMPOSITION / INFORMATION ON INGREDIENTS CAS No EINECS No 77-92-9 8030-78-2 67-63-0 25321-41-9 201-069-1 232-447-4 200-661-7 246-839-8 Citric Acid Ammonium Compounds Propan Xylene Sulphonic Acid C: R36 C:R22-34-50 C:R11-36-67 C:R22-34 15-30% 5-15% <5% <5% 3. HAZARDS IDENTIFICATION Xi N - Irritant - Very Toxic to aquatic organisims This product contains a material with a WEL publish ed in HSE document EH40. 4. FIRST AID MEASURES Eyes : Rinse immediately with copious amounts of water. Ob tain immediate medical attention if symptoms develo p Inhalation : No special measures required Skin : Wash skin immediately and thoroughly with water .Re move contaminated clothing. Obtain medical attentio n if symptoms develop Ingestion : Rinse mouth and then drink one or two glasses of wa ter (or Milk)Obtain medical attention. 5. FIRE FIGHTING MEASURES Suitable extinguishing Media -Co2, extinguishing powder or water jet. Fight larg er fires with a water jet5 or alcohol-resistant foa m. Protective Equipment -No special measures required . 6. ACCIDENTAL RELEASE MEASURES Protection of Personnel -Not required Environmental Precautions -Dilute with plenty of water in case the product re aches water or sewage system. Method of Disposal -Absorb with liquid binding material(sand diatomite , acid binders, universal binders, sawdust .Dispose off the collected material according to local legislation . 7. HANDLING & STORAGE Handling -Use common rules for working with chemicals Explosions and Fires -No special requirements Storag e- According to legislation 8. EXPOSURE CONTROL / PERSONAL PROTECTION Hand : Use chemical resistant gloves made of butyl or nit rile rubber Eyes : Safety glasses are normally not required. However t heir use is recommended in those cases where handli ng the undiluted product involves a risk of splashing Skin : Wear protective overalls or bib.\n2. : Date: 20/07/2008 Revision Number: 1 Page 2 of 2 Respiration : Personal protection is normally not required 9. PHYSICAL & CHEMICAL PROPERTIES Appearance : Clear blue liquid Odour : Slightly perfumed pH : <=2.0 Solubility : Fully Miscible in water Density : 1.14 g/cm 3 10. STABILITY & REACTIVITY Thermal Decomposition -None if used according to specifications. Dangerous reactions -Reacts with Alkalis Hazardous Decomposition Products -None Known. 11. TOXICOLOGICAL INFORMATION Eyes : Causes Irritation. Skin : Causes Irritation. Inhalation : Causes Irritation. . Ingestion : Causes Irritation. 12. ECOLOGICAL INFORMATION When used for its intended purpose this product sho uld not cause adverse effects in the environment. 13. DISPOSAL CONSIDERATIONS Product Recommendation - Disposes of f observing official regulations. Disposal Recommendation -Disposes of f observing official regulations. Recommended Cleaning Agent -Water if necessary with cleaning agent. 14. TRANSPORT INFORMATION EEC Regulation : Xi, Irritant, Sodium Ammonium Compound, UN3082, IMDG/UN : Ammonium Compound, UN3082, Class 9, PG III RID/ADR : Class 9, ICAO/IATA : 9 15. REGULATORY INFORMATION Hazard symbol : Xi, Irritant Risk phrases : R36/38 R50 Irritating to eyes and skin Very Toxic to aquatic organisims Safety phrases : S26 In case of contact with eyes, rinse immediately wit h plenty of water and seek medical advice. S37 Wear suitable gloves S61 Avoid release to the environment. refer to safety data sheet", "domain": "chemistry", "round": 3} +{"url": "https://research.monash.edu/en/publications/rapgef2-connects-gpcr-mediated-camp-signals-to-erk-activation-in-", "date": "2022-06-27T23:20:43Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-27/segments/1656103344783.24/warc/CC-MAIN-20220627225823-20220628015823-00563.warc.gz", "language_score": 0.8836865425109863, "token_count": 285, "dump": "CC-MAIN-2022-27", "global_id": "webtext-fineweb__CC-MAIN-2022-27__0__143762995", "lang": "en", "text": "G protein (heterotrimeric guanine nucleotide-binding protein)-coupled receptor (GPCR)-mediated increases in the second messenger cyclic adenosine monophosphate (cAMP) activate the mitogenactivated protein kinase (MAPK) extracellular signal-regulated kinase (ERK), and in neuroendocrine cells, this pathway leads to cAMP-dependent neuritogenesis mediated through Rap1 and B-Raf. We found that the Rap guanine nucleotide exchange factor Rapgef2 was enriched from primary bovine neuroendocrine cells by cAMP-agarose affinity chromatography and that it was specifically eluted by cAMP. With loss-offunction experiments in the rat neuronal cell line Neuroscreen-1 (NS-1) and gain-of-function experiments in human embryonic kidney 293T cells, we demonstrated that Rapgef2 connected GPCR-dependent activation of adenylate cyclase and increased cAMP concentration with the activation of ERK in neurons and endocrine cells. Furthermore, knockdown of Rapgef2 blocked cAMP-and ERK-dependent neuritogenesis. Our data are consistent with a pathway involving the cAMP-mediated activation of Rapgef2, which then stimulates Rap1, leading to increases in B-Raf, MEK, and ERK activity.", "domain": "chemistry", "round": 3} +{"url": "http://thescipub.com/abstract/10.3844/ajassp.2014.1798.1810", "date": "2018-10-15T21:34:31Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-43/segments/1539583509845.17/warc/CC-MAIN-20181015205152-20181015230652-00008.warc.gz", "language_score": 0.8640867471694946, "token_count": 303, "dump": "CC-MAIN-2018-43", "global_id": "webtext-fineweb__CC-MAIN-2018-43__0__61308423", "lang": "en", "text": "POLYMER COMPOSITE MANUFACTURING USING A PULTRUSION PROCESS: A REVIEW\nA. M. Fairuz, S. M. Sapuan, E. S. Zainudin and C. N.A. Jaafar\nDOI : 10.3844/ajassp.2014.1798.1810\nAmerican Journal of Applied Sciences\nVolume 11, Issue 10\nPultrusion is the one of technologies to fabricate the polymer composites to be used in many industries such as in aerospace, automotive and construction industries. The high performance pultruded products that are produced by this technique offer high fibre content of at least 70%. In order to produce high quality pultruded profiles, there are variables such as fibre impregnation, resin viscosity, pulling speed and curing temperature that have to be considered and these variables are discussed in this study. The review on the recent research in pultrusion process, types of resins used in pultrusion process and mechanical properties of pultuded composites are presented.\n© 2014 A. M. Fairuz, S. M. Sapuan, E. S. Zainudin and C. N.A. Jaafar. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.", "domain": "chemistry", "round": 3} +{"url": "https://beautysense.ca/institut-esthederm-intensive-vitamine-e-serum.html", "date": "2023-06-06T00:19:13Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-23/segments/1685224652184.68/warc/CC-MAIN-20230605221713-20230606011713-00589.warc.gz", "language_score": 0.6607367396354675, "token_count": 419, "dump": "CC-MAIN-2023-23", "global_id": "webtext-fineweb__CC-MAIN-2023-23__0__181489787", "lang": "en", "text": "Vitamin E²: Soothing and protecting formula.\nInstitut Esthederm has combined two complementary forms of Vitamin E in particularly stable, high doses, to create an exclusive complex, Vitamine E². This unique combination improves the availability of Vitamin E and boosts its anti-free radical and anti-inflammatory effects.\nHyperreactive skin, redness, irritation\n|How to use|\nApply morning and evening on the face and the neck, in cure of two months\n|Ingredients||AQUA/WATER/EAU*, GLYCERIN, OCTYLDODECANOL, TOCOPHERYL ACETATE, CYCLOPENTASILOXANE, DIMETHICONE, CYCLOMETHICONE, DISODIUM LAURIMINODIPROPIONATE TOCOPHERYL PHOSPHATES, SODIUM POLYACRYLATE, PHENOXYETHANOL, CHLORPHENESIN, DISODIUM EDTA, PEG/PPG-18/18 DIMETHICONE, TRIDECETH-6, PROPYLENE GLYCOL, DIMETHICONE/VINYL DIMETHICONE CROSSPOLYMER, GLYCERYL ACRYLATE/ACRYLIC ACID COPOLYMER, PHENYL TRIMETHICONE, CARNOSINE, DISODIUM ADENOSINE TRIPHOSPHATE, BENZOIC ACID, LAMINARIA DIGITATA EXTRACT, DEHYDROACETIC ACID. [ES235] * CELLULAR WATER (AQUA/DISODIUM ADENOSINE TRIPHOSPHATE/CARNOSINE/MINERAL SALTS)|\nCreating an account has many benefits: check out faster, keep more than one address, track orders and more.", "domain": "chemistry", "round": 3} +{"url": "http://uu.diva-portal.org/smash/record.jsf?pid=diva2:730457", "date": "2016-10-25T14:23:27Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2016-44/segments/1476988720153.61/warc/CC-MAIN-20161020183840-00365-ip-10-171-6-4.ec2.internal.warc.gz", "language_score": 0.7954460382461548, "token_count": 382, "dump": "CC-MAIN-2016-44", "global_id": "webtext-fineweb__CC-MAIN-2016-44__0__33866023", "lang": "en", "text": "Increased Cycling Efficiency of Lithium Anodes in Dimethyl Sulfoxide Electrolytes For Use in Li-O-2 Batteries\n2014 (English)In: ECS ELECTROCHEM LETT, ISSN 2162-8726, Vol. 3, no 6, A62-A65 p.Article in journal (Refereed) Published\nHigh lithium cycling efficiencies are required if a metal anode system is to be considered for use in Li-O-2 batteries. In this work electrolyte additives (0.3 M LiNO3 and 0.14 M VC) were used to increase the efficiency from 25 to 82.5% in the topical DMSO based electrolyte. Furthermore, we show that oxygen also acts to improve the cycling efficiency to 87%. This work highlights the importance of anode considerations in the development of metal O-2 batteries in alternative solvents (DMSO, Acetonitrile and DMA) and suggests realistic strategies for performance improvements. (C)The Author(s) 2014. Published by ECS. This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 License (CC BY, http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse of the work in any medium, provided the original work is properly cited. All rights reserved.\nPlace, publisher, year, edition, pages\n2014. Vol. 3, no 6, A62-A65 p.\nIdentifiersURN: urn:nbn:se:uu:diva-227581DOI: 10.1149/2.007406eelISI: 000336012400007OAI: oai:DiVA.org:uu-227581DiVA: diva2:730457", "domain": "chemistry", "round": 3} +{"url": "https://www.nist.gov/publications/dielectric-slit-die-line-monitoring-polymer-compounding", "date": "2024-03-02T06:48:48Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707947475757.50/warc/CC-MAIN-20240302052634-20240302082634-00689.warc.gz", "language_score": 0.8578373789787292, "token_count": 282, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__101238468", "lang": "en", "text": "A Dielectric Slit Die for In-Line Monitoring of Polymer Compounding\nAnthony J. Bur, S C. Roth, M M. McBrearty\nThe dielectric slit die is an instrument that is designed to measure electrical, rheological, ultrasonics, optical and other properties of a flowing liquid. In one application it is connected to the exit of an extrudder, pump or mixing machine that passes liquefied material such as molten plastics, solvents, slurries, colloidal suspensions and foodstuffs into the sensing region of slit shaped die. Dielectric sensing is the primary element of the slit die, but in addition to the dielctric sensor, the die contains other sensing devices such as pressure, optical and ultrasonics sensors.The slit die has a flexible design that permits interchangability among sensors and sensor positions. To demonstrate sensor operation, we present data from extrusion and compounding of a polymer/clay nanocomposite.\n, Roth, S.\nand McBrearty, M.\nA Dielectric Slit Die for In-Line Monitoring of Polymer Compounding, Review of Scientific Instruments, [online], https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=852265\n(Accessed March 2, 2024)", "domain": "chemistry", "round": 3} +{"url": "http://globicate.com/radiocarbon-dating-calendar-years-that-match.php", "date": "2019-04-23T16:37:39Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-18/segments/1555578605555.73/warc/CC-MAIN-20190423154842-20190423180842-00447.warc.gz", "language_score": 0.9403688311576843, "token_count": 1679, "dump": "CC-MAIN-2019-18", "global_id": "webtext-fineweb__CC-MAIN-2019-18__0__37091693", "lang": "en", "text": "Radiocarbon dating calendar years that match. Radiocarbon dating - wikipedia\nCombining the effects of these two trees, we see a site that was actually occupied for years from to BCE appearing - using conventional radiocarbon dating - to have been occupied for 30, years from 40, to 9, BCE.\nNow click on the box labelled Enter Data on the left-hand side and the data will be entered into the lower screen.\nRadiocarbon Dating and Archaeology\nIts radiocarbon content then begins to decrease. The dating principle Once an organism dies the carbon is no longer replaced. Knowing the type of contaminants also give radiocarbon scientists an idea on the pretreatment methods needed to be done before starting carbon dating.\nWhat the study does show, then, is that there is no a priori reason why the method should not work on rust. The amount of carbon required was 1g, equivalent to 50 g of a 2.\nJust like C14 dates, calibrated dates are given in a range. However, atmospheric 14C was almost doubled during the s and s due to atmospheric atomic bomb tests.\n» No se encontró la página\nThere are also significant plateaus in the curves, such as the one from 11, to 10, radiocarbon years BP, which is believed to be associated with changing ocean circulation during the Younger Dryas period.\nOver the last 40 years, there has been a discernible increase in the number of scholars who have focused their research on early industrial organizations, a field of study that has come to be known as Archaeotechnology. Two characteristic times can be defined: All animals in the food chain, including carnivores, get their carbon indirectly from plant material, even if it is by eating animals which themselves eat plants.\nWhat do you do know? Carbon has two stable, nonradioactive isotopes: On the Aucilla projects, C14 dating is used as a method for weeding out unpromising sties that are either too old or too young. The radiocarbon dating process starts with measuring Carbon, a weakly radioactive isotope of Carbon, followed by calibration of radiocarbon age results to calendar years.\nThat radiation fluctuates year to year and therefore so does the creation of C As the graph to the right shows, there is an overstatement of the age of the sample of nearly years in an uncalibrated dating of BP.\nA common practice is to report a C14 date as the single expat dating oman date in our example, 10, years. Dormant volcanoes can also emit aged carbon. Chinese Warring States arrowhead dating to about — B. Alkali and acid washes can be used to remove humic acid my two exes are dating websites carbonate contamination, but care has to be taken to avoid destroying or damaging the sample.\nThe event that triggered the massive geothermal upheaval during Noah's life also made the water vapour canopy unstable. This calibration has been done by compiling a dendrochronological tree-ring record and painstakingly figuring the C14 age of these tree rings.\nThese raw dates are also based on a slightly-off historic value for the radiocarbon half-life. Conversely, if it grew at a time of abundant C14 it would appear younger than it should. A variety of sample processing and instrument-based constraints have been postulated to explain the upper age-limit.\nEroded from CaCO3 or organic deposits, old carbon may be assimilated easily and provide diluted 14C carbon into trophic chains. Radiocarbon dating results have insignificant value as in the case when the calibration curve is effectively flat and all calendar events in the period will produce about the same radiocarbon age.\nIn particular, time-sensitive projects like rescue archaeology, waiting months for test results while construction is halted is not viable and can be a financial burden. Your Data Entry Form should now look like this: The present paper deals with an issue of great interest to materials scientists and archeologists—the dating of iron-based materials that contain carbon.\nMore about radiocarbon dating By David Thulman The great promise of radiocarbon C14 dating is that it provides a method for dating and sequencing specific prehistoric events. Nonetheless, iron samples that had completely rusted produced plausible radiocarbon dates, but issues of contamination and post-depositional carbon exchange must be thoroughly tested in a variety of field settings before rust dating can be considered a validated technique.\nThis is taken up by plants through photosynthesis.\nPágina no encontrada\nSo, as iron rusts, the carbide phase will be more stable than the matrix and will remain behind. Complications arising from the recycling of artifacts must also be considered.\nIf the bone was heated under reducing conditionsit and associated organic matter may have been carbonized. This greatly decreased the amount of C14 being produced.\nIt may also be possible to date completely rusted artifacts, commonly found in waterlogged early Iron-Age sites in Europe and in underwater shipwrecks.\nRadiocarbon Dating and Archaeology - AMS lab Beta Analytic\nThere are two reasons why the radiocarbon date is not a true calendar age: The results will be displayed on the upper screen. You have sent your samples off to the lab and received the results back. Since the calibration curve IntCal also reports past atmospheric 14 C concentration using this conventional age, any conventional ages calibrated against the IntCal curve will produce a correct calibrated age.\nThe surface of the earth was also shielded from the effects of ultraviolet radiation by the water vapour layer, another factor making life easier in the past.\nIf the accelerated decay rate lasted the entire days that the Ark was afloat when the water would provide effective shielding for its occupantsit would cover the most active phase of sedimentation during the Flood.\nAfter the Flood, there is a steady increase in the production rate of carbon This, however, is only a small part of the uncertainty of the final age determination see section Calibration below.\nWhat can be dated?\nCarbon exchange reservoir Libby's original exchange reservoir hypothesis assumes that the exchange reservoir is constant all over the world. Unburnt bone can be tested; it is usual to date it using collagenthe protein fraction that remains after washing away the bone's structural material.\nAs we go farther back in time, the difference between the two dating systems becomes greater. Decay of carbon 14 takes thousands of years, and it is this wonder of nature that forms the basis of radiocarbon dating and made this carbon 14 analysis a powerful tool in revealing the past.\nHemisphere effect The northern and southern hemispheres have atmospheric circulation systems that are sufficiently independent of each other that there is a noticeable time lag in mixing between the two.\nWhen a date is quoted, the reader should be aware that if it is an uncalibrated date a term used for dates given in radiocarbon years it may differ substantially from the best estimate of the actual calendar date, both because it uses the wrong value for the half-life of 14 C, and because no correction calibration has been applied for the historical variation of 14 C in the atmosphere over time.\nAluminum containers with screw caps are safe, but it is still best to consult the radiocarbon laboratory for the best containers of carbon dating samples.\nThe nuances of radiocarbon dating of iron-based materials will be explained by way of example in this paper. If testing recrystallized shell is unavoidable, it is sometimes possible to identify the original shell material from a sequence of tests.\nPrevious investigators had been careful to remove rust from iron prior to dating for fear that it adds contamination. A particular difficulty with dried peat is the removal of rootlets, which are likely to be hard to distinguish from the sample material.\nBefore this can be done, the sample must be treated to remove any contamination and any unwanted constituents. Shells from both marine and land organisms consist almost entirely of calcium carbonate, either as aragonite or as calciteor some mixture of the two.", "domain": "chemistry", "round": 3} +{"url": "https://scholar.oxy.edu/handle/20.500.12711/402", "date": "2021-05-18T04:11:16Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-21/segments/1620243989820.78/warc/CC-MAIN-20210518033148-20210518063148-00044.warc.gz", "language_score": 0.9368389248847961, "token_count": 261, "dump": "CC-MAIN-2021-21", "global_id": "webtext-fineweb__CC-MAIN-2021-21__0__148916389", "lang": "en", "text": "Tank bromeliads such as Aechmea nudicaulis tend to have an acidic body of water contained in the center of their tight leaf rosette. This tank of water grows larger with the bromeliad and collects fallen debris and precipitation. These epiphytic bromeliads have evolved to take up water from within their tanks and have no ability to absorb water through their roots which instead only anchor the plant to a host tree. The bromeliads have become dependent on aerobic and anaerobic bacteria living within the tank to break down debris and make nutrients available. Previous investigations of the bacterial communities of neotropical bromeliad tanks found an experimentally supported relationship between tank pH, which can range from 3.5-6.0, and specific bacterial community composition and diversity (Goffredi et al. 2011). To identify if sunlight is a factor determining pH, 32 A. nudicaulis were kept in a growth chamber under 4 different light conditions. After a 2 month long treatment we have determined that there is a significant difference in tank pH of bromeliads exposed to high and low-light conditions (lower pH in higher-light conditions) indicating that light plays a part in determining tank pH and therefore bacterial community composition.", "domain": "chemistry", "round": 3} +{"url": "https://roff.in/grouting-solutions/roff-rainbow-tile-mate-rtm-wide-additive/", "date": "2018-10-20T19:53:25Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-43/segments/1539583513384.95/warc/CC-MAIN-20181020184612-20181020210112-00321.warc.gz", "language_score": 0.7986628413200378, "token_count": 269, "dump": "CC-MAIN-2018-43", "global_id": "webtext-fineweb__CC-MAIN-2018-43__0__30715491", "lang": "en", "text": "Roff Rainbow Tile Mate (RTM) Wide Additive\nSanded grout with additive for wider tile joints\nAdditive for cementitious tile grout.\nA liquid additive to be used with cementitious colour tile grouts to fill the tile joints of ceramic, vitrified and natural stone tiles. Roff Rainbow Tile Mate (RTM) Wide Additive is used in place of water to improve the performance of Roff Rainbow Tile Mate (RTM), with regards to colour fastness, flexibility, waterproofing and abrasion resistance.\nADDING ENDURANCE TO BEAUTY\nPour Roff Rainbow Tile Mate (RTM) or Rainbow Tile Mate (RTM) Wide Additive in a pot.\nAlways mix three to 3.5 parts of Roff Rainbow Tile Mate (RTM) Wide Additive to Rainbow Tile Mate (RTM) or Rainbow Tile Mate (RTM) Wide.\nMix to a smooth consistency.\nPour the filler paste on the tiles and fill the gaps by spreading it in the spaces in-between the tiles, with the help of a rubber trowel.\nRemove the surplus grout with a damp sponge. Allow 24 hours for the filling to dry.\n- Excellent resistance.\n- No water curing required.\n- Flexible joint filling.", "domain": "chemistry", "round": 3} +{"url": "https://satisfactory.wiki.gg/wiki/Tutorial:Setting_up_Aluminum_Ingot_production", "date": "2023-11-28T17:32:09Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679099892.46/warc/CC-MAIN-20231128151412-20231128181412-00881.warc.gz", "language_score": 0.859880268573761, "token_count": 345, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__8984437", "lang": "en", "text": "Tutorial:Setting up Aluminum Ingot production\nAluminum Production is unlocked at Tier 7 - Bauxite Refinement. Once unlocked, you can set up Aluminum Ingot production.\nAluminum Ingot production is done in 3 steps. The first step is producing Alumina Solution, which requires Bauxite and Water, and has a byproduct of Silica. The second step is producing Aluminum Scrap, which takes Alumina Solution and has a byproduct of Water. The third step is producing Aluminum Ingot, which requires Aluminum Scrap and Silica.\nReusing waste Water is the main initial challenge when setting up Aluminum Ingot production. Piping it back to the original supply requires difficult piping. An alternative is to use waste water as the only source for a single Alumina Solution producer.\nHere we focus on building a minimal unit that reuses all of the waste water, and doesn't get stuck.\nStep 0 - basic resources\nAcquire basic resources:\nOver- or under-provisioning any resources will not break the setup. Under-provisioning will slow it down.\nStep 1 - Alumina Solution production\nStep 2 - Aluminum Scrap production\nStep 3 - Aluminum Ingot production\nThis setup produces total of 180 Aluminum Ingot/m.\nThe setup described above can be used as a minimal unit (later called a Production Node), and repeated side-by-side to increase production. However, some improvements can be made. They save you building space, but not resources nor energy.\nImprovement 1 - Reuse waste water Refinery from Step 1\nImprovement 2 - Reuse scrap Refinery from Step 2", "domain": "chemistry", "round": 3} +{"url": "https://irf.fhnw.ch/handle/11654/33941", "date": "2023-01-29T09:13:34Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-06/segments/1674764499710.49/warc/CC-MAIN-20230129080341-20230129110341-00077.warc.gz", "language_score": 0.6856339573860168, "token_count": 383, "dump": "CC-MAIN-2023-06", "global_id": "webtext-fineweb__CC-MAIN-2023-06__0__235968651", "lang": "en", "text": "Engineering efficient hole transport layer Ferrihydrite-MXene on BiVO4 photoanodes for photoelectrochemical water splitting: Work function and conductivity regulated\n01A - Beitrag in wissenschaftlicher Zeitschrift\nAlthough great interest is focused on development of semiconductor photoanodes for efficient photoelectrochemical (PEC) water splitting, the pressing bottleneck to address the intrinsic charge transport for enhancement of PEC performance still remains to be resolved. Herein, hole transport layer (Fh-MXene) constructed by doping of MXene (Ti3C2) in Ferrihydrite (Fh) is loaded on BiVO4 photoanode. This novel BiVO4@Fh-MXene photoanode achieves high current density of 4.55 mA cm−2 at 1.23 V versus reversible hydrogen electrode (vs. RHE), exhibiting excellent photostability. From electrochemical analysis and density functional theory calculations, high PEC performance is ascribed to incorporation of Fh-MXene as hole transport layer, enhancing conductivity and water oxidation reaction. Notably, MXene can improve band alignment of BiVO4/Fh-MXene interface by tuning work function, which strengthens the built-in electric field for more efficient hole extraction. This work provides a simple method to design photoanodes with efficient charge transport layers for feasible PEC water splitting application.\nDOI der Originalausgabehttps://doi.org/10.1016/j.apcatb.2022.121606\nApplied Catalysis B: Environmental\nVerlag / Hrsg. Institution", "domain": "chemistry", "round": 3} +{"url": "http://www.ykbsc.chem.tohoku.ac.jp/member/2016/Daisuke_Sakamoto.html", "date": "2023-06-03T15:01:41Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-23/segments/1685224649293.44/warc/CC-MAIN-20230603133129-20230603163129-00246.warc.gz", "language_score": 0.7351774573326111, "token_count": 341, "dump": "CC-MAIN-2023-23", "global_id": "webtext-fineweb__CC-MAIN-2023-23__0__298551588", "lang": "en", "text": "Related Publication and Patents\n4. One-Pot Synthesis of (R)-Baclofen via Aldol Condensation of Acetaldehyde with Diphenylprolinol Silyl Ether Mediated Asymmetric Michael Reaction as a Key Step\nYujiro Hayashi, Daisuke Sakamoto, and Daichi Okamura\n3. Asymmetric Mannich reaction of alpha-keto imines catalyzed by diarylprolinol silyl ether.\nHayashi Y, Sakamoto D, Shomura H, Hashizume D.\nChem. Eur. J., 19, 7678 (2013).\n2. One-Pot Synthesis of Chiral Aziridines by a Domino Reaction by Using Desulfonylative Formation on the N-Tosyl Imine of Chloroacetaldehyde with an Asymmetric Mannich Reaction as a Key step\nY. Hayashi, T. Urushima, D. Sakamoto, K. Torii and H. Ishikawa\nChem. Eur. J., 17, 11715 (2011).\n1. Enantio- and Diastereoselective Synthesis of Piperidines by Coupling of Four Components in a \"One-Pot\" Sequence Involving Diphenylprolinol Silyl Ether Mediated Michael Reaction\nT. Urushima, D. Sakamoto, H. Ishikawa, and Y. Hayashi\nOrg.Lett., 12, 4588 (2010).", "domain": "chemistry", "round": 3} +{"url": "https://www.mysciencework.com/publication/show/activation-up-regulation-phospholipase-d-expression-lipopolysaccharide-human-peripheral-t-cells-d224d6ad", "date": "2018-09-22T18:59:37Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-39/segments/1537267158633.40/warc/CC-MAIN-20180922182020-20180922202420-00380.warc.gz", "language_score": 0.9179456233978271, "token_count": 367, "dump": "CC-MAIN-2018-39", "global_id": "webtext-fineweb__CC-MAIN-2018-39__0__128716404", "lang": "en", "text": "In a previous study, we showed that bacterial LPS activates protein kinase C (PKC) and causes an intracellular pH (pHi) increase, but does not elevate intracellular calcium ([Ca2+]i) in human peripherial T cells. Hence this study aimed to investigate whether the activation of PKC was resulted from phospholipase D (PLD) catalysis by LPS. The activity of PLD was measured by the production of 3H-phosphatidylethanol from phosphatidic acid (PA), and the expression of PLD or IL-2 Ralpha was determined by reverse transcription-polymerase chain reaction (RT-PCR) analysis. Enzyme-linked immunosorbent assay (ELISA) was used to analyze IL-2 and IL-4. Phytohemagglutinin (PHA), and phorbol 12-myristate 13-acetate (PMA) were used as controls. Our results indicated that (1) LPS-stimulated pHi elevation was PKC dependent; (2) After 30 min stimulation, LPS increased PLD activity via a measured production of 3H-phosphatidylethanol from phosphatidic acid and the initiation of PLD1a mRNA expression started; (2) LPS stimulated IL-2 R expression but not IL-2 and IL-4 secretion. Our findings suggested that the stimulation of PLD activity and its mRNA expression by LPS might be required for IL-2 R expression and a sustained PKC dependent pHi elevation but not for the secretion of IL-2 or IL-4 in human T cells. This indicated that LPS might enhance T cell adaptive immunity to resist Gram-negative bacterial infection.", "domain": "chemistry", "round": 3} +{"url": "https://www.hgweb.nl/agent-from-china-concrete.html", "date": "2020-07-13T05:00:47Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-29/segments/1593657142589.93/warc/CC-MAIN-20200713033803-20200713063803-00172.warc.gz", "language_score": 0.8613731861114502, "token_count": 1301, "dump": "CC-MAIN-2020-29", "global_id": "webtext-fineweb__CC-MAIN-2020-29__0__104479596", "lang": "en", "text": "Water reducing agent e ects on the engineering\n2019-9-1 · Water reducing agent e ects on the engineering performance of cement stabilized aggregates ... are usually utilized in cement concrete to reduce the water-cement ratio, increase mechanical strength, and improve the durability of concrete struct\nUCLA researchers turn carbon dioxide into sustainable\n2016-3-14 · UCLA researchers turn carbon dioxide into sustainable concrete. ... But the production of cement, which when mixed with water forms the binding agent in concrete, is also one of the biggest contributors to greenhouse gas emissions. ... “But ev\nLargest Manufacturer of Packaged Concrete | QUIKRETE\nThe QUIKRETE® Companies - Largest manufacturer of packaged concrete in the United States and leader in the commercial building and home improvement industries.\nasphalt concrete plant - teamkranenburg.nl\nAsphalt Concrete Production Rate If this is an initial registration for an Asphalt Concrete Plant, provide an estimate of the total production rate of asphaltic concrete, in tons, expected in the initial 12-month period If this is a re-registration for an\nHow does the concrete batching plant work? - Quora\nA concrete plant, also known as a batch plant or batching plant, is a device that combines various ingredients to form concrete. Some of these inputs include sand, water, aggregate (rocks, gravel, etc.), fly ash, potash, and cement. There are two ...\nSeven Must-Use Concrete Admixtures (Additives)\nSet retarding admixtures are used in concrete pavement construction, allowing more time for finishing concrete pavements, reducing additional costs to place a new concrete batch plant on the job site and helps eliminate cold joints in concrete.\nCoal & cement | World Coal Association\n2019-9-2 · Coal & cement Varying the mix of cement, sand and aggregate enables concrete to be used in a range of applications. Products can be designed, coloured and shaped to accommodate a variety of environmental conditions, architectural requirements a\nHIGH-STRENGTH STRUCTURAL LIGHTWEIGHT CONCRETE\n2006-6-7 · HIGH-STRENGTH STRUCTURAL LIGHTWEIGHT CONCRETE ... water and an expansion agent. The bubble is made by adding expansion agents [aluminum powder or hydrogen peroxide] to the mix during the mixing process. This creates a chemical reaction that ...\nFoam Concrete, CLC | Luca Industries International GmbH\n2019-9-3 · Foam concrete. Foam concrete, the other type of cellular lightweight concrete, is produced with harmless foam, which is mixed into the slurry. A foaming agent is diluted with water and expanded with air within a foam generator and is then added\nAsphalt mixing plant | Heavy equipment\n2019-8-30 · Asphalt mixing plant. PHOTO | FILE. A major booster of efficiency in the construction industry, an asphalt mixing plant is a machine that creates hot mix asphalt (HMA). HMA or asphalt concrete is primarily used in the construction of roads and\n2019-9-2 · Once the ingredients are mixed, workers must put the concrete in place before it hardens. In modern usage, most concrete production takes place in a large type of industrial facility called a concrete plant, or often a batch plant. In general u\nChina Concrete Mixer manufacturer, Concrete Batching Plant\nConcrete Mixer, Concrete Batching Plant, Concrete Planetary Mixer manufacturer / supplier in China, offering Self Loading Mobile Concrete Mixer From Factory, Portable Concrete Mixer Truck by 4.0 M3, Slef Loading Mobile Concrete Mixer 4.0 and so on.\nCement Industry Is at Center of Climate Change Debate\n2007-10-26 · A cement plant worker in China. Making cement to bind concrete produces carbon dioxide that causes global warming. Credit Reuters . PARIS, Oct. …\nReady-mixed Concrete Mixing Plant - NFLG China: Asphalt\nReady-mixed concrete mixing plant referred to concrete plant or batching plant, is an equipment that combines various ingredients to form concrete. NFLG concrete mixing plants enable concrete to be manufactured economically.\nBusiness plan ready mix concrete - Custom Dissertation\nBusiness plan ready mix concrete - Stop getting unsatisfactory marks with these custom essay tips begin working on your essay right away with professional guidance presented by the company Proofreading and editing aid from best specialists.\nRoad Construction - Sinoway Industrial (Shanghai) Co., Ltd\nRoad Rollers, Wheel Loaders, Motor Graders manufacturer / supplier in China, offering 120 M3/H Ready Mix Concrete Mixing Plant, Cement Batching Plant, 260HP Tire Material Handler with Grab Wheel Material Handling Equipment, 40-320 Ton Asphalt Batching Pla\nconcrete mixing plant from 75 to 400 ,[#8##]\nConcrete Batching Plant, Concrete Mixing Plant, Concrete Mixing Station manufacturer / supplier in China, offering Concrete Mixing Station, Mixing Plant, Block Cuber, Automatic Independent Cuber System and so on. HZS180 Concrete Batching Plant - Dry Morta\nManufacturer producer concrete mixers | Europages\nAbout EUROPAGES. EUROPAGES is a European B2B platform available in 26 linguistic versions. With 3 million listed companies, mainly manufacturers, wholesalers, distributors and service providers, every month EUROPAGES attracts more than 2 million decision-\nChina 90m3/H Capacity Concrete Mixing Plant of Belt\nChina 90m3/H Capacity Concrete Mixing Plant of Belt Conveyor Type, Find details about China Sicoma Mixer, Batching Plant from 90m3/H Capacity Concrete Mixing Plant of Belt Conveyor Type - SHANDONG MACPEX MACHINERY EQUIPMENT CO., LTD.\nLiebherr Batching Plant, Liebherr Batching Plant Suppliers\nThere are 150 liebherr batching plant suppliers, mainly located in Asia. The top supplying countries are China (Mainland), Iran (Islamic Republic of), and India, which supply 98%, 1%, and 1% of liebherr batching plant respectively. Liebherr batching plant", "domain": "chemistry", "round": 3} +{"url": "http://products.invitrogen.com/ivgn/product/C10502", "date": "2013-05-25T12:48:11Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2013-20/segments/1368705953421/warc/CC-MAIN-20130516120553-00064-ip-10-60-113-184.ec2.internal.warc.gz", "language_score": 0.8831486105918884, "token_count": 858, "dump": "CC-MAIN-2013-20", "global_id": "webtext-fineweb__CC-MAIN-2013-20__0__209917446", "lang": "en", "text": "CellLight® Actin-RFP is a modified insect virus (baculovirus) containing an actin-red fluorescent protein fusion construct. CellLight® reagents combine the utility and selectivity of fluorescent proteins with the transduction efficiency of BacMam technology, enabling unambiguous staining of organelles, cellular structures, and processes in live mammalian cells. They are provided in a ready-to-use format—simply add, incubate, and image—with highly efficient expression in cell lines, primary cells, stem cells, and neurons.\nCellLight® Actin-RFP is:\n• Highly Efficient:\n>90% transduction of a wide range of mammalian cell lines, including primary cells, stem cells, and neurons\n• Fast and Convenient:\nSimply add CellLight® Actin-RFP reagent to your cells, incubate overnight, and image—or store frozen, assay-ready cells for later use\nCellLight® reagents are non-replicating in mammalian cells, lack observable cytopathic effect, and are suitable for biosafety level (BSL) 1 handling\nYou can co-transduce more than one BacMam reagent for multiplex experiments or co-localization studies and tightly control expression levels by just varying the doseCellLight® Reagents Principle\nCellLight® reagents are fusion constructs of signal peptides or cell structure proteins with premiere emGFP, TagRFP, or CFP for accurate and specific targeting to sub-cellular compartments and structures. A variety of targets, including cytoskeleton, mitochondria, and secretory compartments, are available for convenient multiplexing, co-localization studies, and imaging of dynamic cellular processes where high spatial and temporal resolution is required. The CellLight® reagents tolerate fixation with formaldehyde and are therefore compatible with fixed-cell analysis.BacMam Technology\nThe BacMam technology is based on an insect virus (baculovirus) for efficient transduction and transient expression in mammalian cells. The baculovirus has been modified to include an expression cassette containing the CellLight® fusion construct. BacMam 2.0 incorporates elements that help greatly enhance transduction efficiency and expression levels: a pseudotyped capsid protein for more efficient cell entry, an enhanced CMV promoter, and the Woodchuck hepatitis post-transcriptional regulatory element (WPRE). Baculoviruses do not replicate in mammalian cells and thus have an excellent safety profile and lack cytopathic effects on cells.Workflow Convenience\nUnlike expression vectors, BacMam reagents enable titratable and reproducible transient protein expression. There is no need for harsh transfection methods or tedious cloning. To achieve highly efficient expression even in sensitive cells, such as stem cells, neurons, and primary cells, just add CellLight® reagents to cells in complete medium, incubate, and image the next day. Alternatively, mix CellLight® reagent and cells at the time of plating.\nCo-transduction efficiencies are high allowing multiple CellLight® reagents to be readily used in the same experiment when multiple structures or pathways need to be labeled. CellLight® reagents also tolerate fixation with formaldehyde and are thus compatible with antibody-based fixed-cell analysis.\nTypically, transiently transduced cells express fusion protein for about five days, though in slowly dividing cells, such as some primary cell types, expression has been demonstrated for up to two weeks; in terminally differentiated neurons we have recorded images more than three weeks after transduction.Related Products\nWe offer a range of BacMam-based reagents beyond CellLight® reagents, including the BacMam GFP Transduction Control\nthat is ideal to test out the technology and optimize transduction conditions, Premo™ Biosensors, including Premo™ Autophagy Sensor\n, ion channel drug targets, pathway analysis kits, and more.Learn more about these products and the BacMam technologySee other imaging tools and reagents\nFor Research Use Only. Not intended for any animal or human therapeutic or diagnostic use.", "domain": "chemistry", "round": 3} +{"url": "https://link.springer.com/article/10.1007%2Fs00253-012-4541-y", "date": "2019-06-19T08:49:10Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-26/segments/1560627998943.53/warc/CC-MAIN-20190619083757-20190619105757-00379.warc.gz", "language_score": 0.8080833554267883, "token_count": 1260, "dump": "CC-MAIN-2019-26", "global_id": "webtext-fineweb__CC-MAIN-2019-26__0__60001390", "lang": "en", "text": "Construction and expression of sTRAIL–melittin combining enhanced anticancer activity with antibacterial activity in Escherichia coli\n- 645 Downloads\nTumor necrosis factor-related apoptosis-inducing ligand (TRAIL), as an anticancer protein with tumor-selective apoptotic activity, has been examined for use in clinical application. Melittin, an antibacterial peptide isolated from the bee Apis mellifera, has shown strong cytotoxicity to both tumor and normal cells. To ameliorate the cytotoxicity of melittin on cells and enhance the activity of TRAIL on cancer cells, we constructed a novel fusion protein, sTRAIL–melittin, containing a small ubiquitin-related modifier (SUMO) tag and expressed this fusion protein in Escherichia coli. Data showed that expression of the soluble fusion protein with the SUMO tag was approximately 85 % of total target protein which was much higher than that without the SUMO tag (approximately 10 %); sTRAIL–melittin was easily purified using Ni-NTA affinity chromatography and the tag was removed easily using SUMO-specific protease. To assay anticancer activity and side effects, methyl thiazolyl tetrazolium, hemolytic, and apoptosis assays were employed. Results demonstrated that sTRAIL–melittin had cytotoxic and apoptotic activity in K562 leukemia cells and HepG2 liver carcinoma cells, while it had only a minimal effect on erythrocytes and normal HEK293 cells. This indicates that the cytotoxicity of sTRAIL–melittin in normal cells was low and the anticancer activity of the fusion protein in tumor cells was significantly enhanced compared with sTRAIL (P < 0.01). Furthermore, we found that sTRAIL–melittin also showed antibacterial activity to Staphylococcus aureus due to the presence of the melittin domain. Therefore, TRAIL fused with an antibacterial peptide may be a promising novel TRAIL-based anticancer treatment strategy.\nKeywordsSUMO sTRAIL Melittin Anticancer Escherichia coli\nThis work was financially supported by a grant of the National Natural Science Foundation of China (Grant no. 30900743), the Natural Science Foundation of Jiangsu Province of China (Grant no. BK2011368), the Natural Science Foundation of Jiangsu Higher Education Institutions of China (Grant no. 2008104TSJ0096), and the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD).\n- Bommarius B, Jenssen H, Elliott M, Kindrachuk J, Pasupuleti M, Gieren H, Jaeger KE, Hancock RE, Kalman D (2010) Cost-effective expression and purification of antimicrobial and host defense peptides in Escherichia coli. Peptides 31:1957–1965. doi: 10.1016/j.peptides.2010.08.008 CrossRefGoogle Scholar\n- Casteels P, Ampe C, Jacobs F, Tempst P (1993) Functional and chemical characterization of hymenoptaecin, an antibacterial polypeptide that is infection-inducible in the honeybee (Apis mellifera). J Biol Chem 268:7044–7054Google Scholar\n- Dorsey JF, Mintz A, Tian X, Dowling ML, Plastaras JP, Dicker DT, Kao GD, El-Deiry WS (2009) Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and paclitaxel have cooperative in vivo effects against glioblastoma multiforme cells. Mol Cancer Ther 8:3285–3295. doi: 10.1158/1535-7163.mct-09-0415 CrossRefGoogle Scholar\n- Gasparian ME, Ostapchenko VG, Yagolovich AV, Tsygannik IN, Chernyak BV, Dolgikh DA, Kirpichnikov MP (2007) Overexpression and refolding of thioredoxin/TRAIL fusion from inclusion bodies and further purification of TRAIL after cleavage by enteropeptidase. Biotechnol Lett 29:1567–1573. doi: 10.1007/s10529-007-9446-y CrossRefGoogle Scholar\n- Miran J, Mi HP, Pushpa SK, Byeong JA, Ho SS, Sang BH, Jang HK, Min JS, Jin TH (2011) Anti-cancer effect of bee venom toxin and melittin in ovarian cancer cells through induction of death receptors and inhibition of JAK2/STAT3 pathway. Toxicol Appl Pharm 258:72–81. doi: 10.1016/j.taap. 2011.10.009 Google Scholar\n- Tang HY, Qin Y, Li JY, Gong XG (2011) The scavenging of superoxide radicals promotes apoptosis induced by a novel cell-permeable fusion protein, sTRAIL:FeSOD, in tumor necrosis factor-related apoptosis-inducing ligand-resistant leukemia cells. BMC Biol 9:18. doi: 10.1186/1741-7007-9-18 CrossRefGoogle Scholar\n- Wang C, Chen TY, Zhang N, Yang MJ, Li B, Lu X, Cao XT, Ling C (2009) Melittin, a major component of bee venom, sensitizes human hepatocellular carcinoma cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis by activating CaMKII-TAK1-JNK/p38 and inhibiting IκBα Kinase-NFκB. J Biol Chem 284:3804–3813. doi: 10.1074/jbc.m807191200 CrossRefGoogle Scholar", "domain": "chemistry", "round": 3} +{"url": "http://www.ask.com/home-garden/remove-fingernail-glue-fdd4ca3fe0ce5f59", "date": "2015-05-04T21:25:44Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2015-18/segments/1430455119811.95/warc/CC-MAIN-20150501043839-00061-ip-10-235-10-82.ec2.internal.warc.gz", "language_score": 0.9041037559509277, "token_count": 514, "dump": "CC-MAIN-2015-18", "global_id": "webtext-fineweb__CC-MAIN-2015-18__0__150032004", "lang": "en", "text": "Remove nail glue by soaking, filing and applying nail polish remover. The process takes several minutes and a well-lit area to ensure all the glue is removed. Gather cotton balls, a small lamp, fingernail file, fingernail polish remover, a small towel and a small bowl.Know More\nSelect an area in the home that has a lot of light so that no glue is missed. If available, place a small lamp on the table, and shine the light toward the nails.\nFill the small bowl with warm water, and place the fingertips of one hand in the bowl. Allow them to soak for about two minutes. Remove hand, and dry off.\nUsing a nail file, gently file off any clumps of glue. Continue until the nails are smooth.\nSoak the fingers on the other hand for two minutes. Remove, dry, and repeat step three.\nDab some fingernail polish remover onto a cotton ball, and gently rub it on the nails.\nDry fingers with a towel, and inspect the nails. If there is remaining glue, repeat all the steps.\nTo remove Super Glue, apply a nail polish remover that contains acetone to the glue, and let it sit for five minutes. Loosen the glue with a soft brush or a plastic scrubbing pad. Repeat as necessary. Remove the nail polish remover with a rag and warm, soapy water.Full Answer >\nKrazy Glue can be removed from most surfaces by applying acetone, a powerful solvent, to the bonded area. Acetone-based nail polish removers and acetone solvents from paint stores both work well. Apply the acetone to the Krazy Glue, and let it sit for a few minutes to dissolve the glue. Then, wipe away both the glue and the liquid acetone with a dry towel.Full Answer >\nRemoving Super Glue or similar cyanoacrylate adhesives from fingers begins with a good soak in warm, soapy water. After prying fingers apart, remove the remaining dried-on glue with either water or nail polish remover.Full Answer >\nTo remove super glue from plastic, apply a small amount of acetone, nail polish remover or a de-bonding agent, then separate the glue from the plastic.\nSuper glue is marketed under numerous commercial names, such as Krazy Glue and Loctite, but the same chemicals dissolve all types of super glue.Full Answer >", "domain": "chemistry", "round": 3} +{"url": "http://www.montana.edu/news/15749/potential-health-consequences-of-open-pit-mining-in-butte-to-be-discussed-at-oct-1-caf-scientifique", "date": "2017-10-23T22:32:25Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-43/segments/1508187826840.85/warc/CC-MAIN-20171023221059-20171024001059-00209.warc.gz", "language_score": 0.9026748538017273, "token_count": 721, "dump": "CC-MAIN-2017-43", "global_id": "webtext-fineweb__CC-MAIN-2017-43__0__29607545", "lang": "en", "text": "Montana Tech associate professor of biochemistry Katie Hailer will speak at Montana State University’s upcoming Café Scientifique.\nHailer will present “Peering down the Pit: Assessing Human Metal Accumulations near an Urban Superfund Site” at 6 p.m. Thursday, Oct. 1, at the Baxter Hotel Ballroom in downtown Bozeman. The event is free and open to the public.\nButte is home to approximately 35,000 residents living adjacent to one of the largest concentrated areas of environmental contamination in the United States. While the decommissioned Berkeley Pit copper mine has garnered national attention as a Superfund site, fewer people are as aware that other open-pit mines continue to operate in close proximity to Butte’s urban population, according to Hailer. To date, most scientific research has focused on assessing water and soil contamination related to past decades of mining. Hailer’s talk will instead focus on current mining operations’ ongoing effects on air pollution and soil contamination and the potential health consequences for local residents.\nHailer’s presentation will cover her research methodology and her preliminary data, including finding statistically higher levels of copper, manganese and molybdenum in Butte residents compared to a control group in Bozeman. She will also discuss follow-up research conducted in 2014 and 2015, which revealed elevated levels of copper, manganese, lead, selenium and zinc in Butte residents.\nHailer hopes to conduct further research into how chronic exposure to metal mixtures might play a role in activating dormant genetic medical conditions. The National Institute of Neurological Disorders and Stroke, a component of the National Institutes of Health, lists metal exposure as an environmental risk factor linked to neurodegenerative disorders like dementia. The role of metals in neurodegeneration is a rapidly expanding field of scientific research involving contributions from molecular genetics, biochemistry, and biometal imaging.\nHailer is an associate professor of biochemistry at Montana Tech of the University of Montana. She received a bachelor’s degree in chemistry from West Virginia University and a doctorate in chemistry from the University of Montana. She completed a postdoctoral fellowship at the Mayo Clinic in Rochester, Minn., before teaching at Winona State University from 2007-2009. Hailer joined Montana Tech’s chemistry department in 2010.\nCafé Scientifique, co-sponsored by Montana's INBRE and COBRE programs, provides a relaxed setting for people to learn about current scientific topics. The concept started in England in 1998 and has spread to a handful of locations in the United States. Following a short presentation by a scientific expert, the majority of time is reserved for lively conversation, thoughtful questions and respectful dialog. Refreshments are provided free of charge.\nHoused at MSU, Montana INBRE and COBRE are each an Institutional Development Award (IDeA) from the National Institute of General Medical Sciences of the National Institutes of Health under grant numbers P20GM103474 (INBRE) and GM103500 (COBRE).\nFor more information, contact Laurie Howell at (406) 994-7531 or email@example.com. For more information about the Café Scientifique concept, check the Web at http://www.inbre.montana.edu/cafe.php.\nContact: Laurie Howell, (406) 994-7531 or firstname.lastname@example.org", "domain": "chemistry", "round": 3} +{"url": "https://pure.korea.ac.kr/en/publications/organelle-specific-fluorescent-phenomics-and-transcriptomic-profi", "date": "2024-04-25T14:24:51Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712297295329.99/warc/CC-MAIN-20240425130216-20240425160216-00598.warc.gz", "language_score": 0.9232742190361023, "token_count": 302, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__89795284", "lang": "en", "text": "Tris(1,3-dichloro-2-propyl)phosphate (TDCPP) has been suspected to cause toxicity invertebrates, but its phenotypic effects and the underlying regulatory mechanism have not been fully revealed. Generally, cellular responses tightly control and affect various phenotypes. The scope of the whole organism or cellular toxicological phenotyping, however, has been limited, and quantitative analysis methods using phenotype data have not been fully established. Here, we demonstrated that fluorescence imaging of sub-organelle-based phenomic analysis together with transcriptomic profiling can enable a comprehensive understanding of correlations between molecular and phenomic events. To reveal the cellular response to TDCPP exposure, we obtained three sub-organelle images as fluorescent phenotypes. Transcriptomic perturbation data were measured from the RNA-seq experiment, and both profiling results were analyzed together. Interestingly, organelle phenomic data showed a unique fluorescent intensity increase in the endoplasmic reticulum (ER), and pathway analysis using transcriptomic data also revealed that ER was significantly enriched in gene ontology terms. Following the series of analyses, RNA-seq data also revealed potential carcinogenic effects of TDCPP. Our multi-dimensional profiling approach for organophosphate chemicals can uniquely correlate phenotypic changes with transcriptomic perturbations.\nBibliographical notePublisher Copyright:\n© 2022, The Author(s).\nASJC Scopus subject areas", "domain": "chemistry", "round": 3} +{"url": "https://www.offshore-technology.com/marketdata/yili-coal-company-yili-complex-china/", "date": "2022-09-28T18:11:52Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-40/segments/1664030335276.85/warc/CC-MAIN-20220928180732-20220928210732-00782.warc.gz", "language_score": 0.8876105546951294, "token_count": 348, "dump": "CC-MAIN-2022-40", "global_id": "webtext-fineweb__CC-MAIN-2022-40__0__41224070", "lang": "en", "text": "Yili Coal Company Yili Complex is an upcoming petrochemical complex located in Xinjiang, China. The complex is expected to commence commercial operations in 2022 and is likely to have an annual petrochemical capacity of 2.4mtpa. The plants in this complex are operated by Yili Coal Coal Energy.\nDetails of key upcoming projects in Yili Coal Company Yili Complex\nThe complex is set to add capacity with upcoming plants including Yili Coal Company Yili Ethylene Plant (0.3mtpa), Yili Coal Company Yili Methanol Plant (1.8mtpa), and Yili Coal Company Yili Propylene Plant (0.3mtpa).The operator details for upcoming plants are as follows:\n|Yili Coal Company Yili Ethylene Plant||Yili Coal Coal Energy|\n|Yili Coal Company Yili Methanol Plant||Yili Coal Coal Energy|\n|Yili Coal Company Yili Propylene Plant||Yili Coal Coal Energy|\nKey Products Capacity – Yili Coal Company Yili Complex, 2021-2030\nThe complex is expected to produce key products such as methanol, propylene, and ethylene.\nMethanol accounts for major capacity share i.e., 75% of the total annual capacity of the complex with 1.8mtpa.\nInformation on the petrochemical complexes/plants is sourced from GlobalData’s oil & gas petrochemicals plants database that provides detailed information on all active and upcoming, petrochemical plants globally. Not all companies mentioned in the article may be currently existing due to their merger or acquisition or business closure.", "domain": "chemistry", "round": 3} +{"url": "https://cfpslakeland.com/pool-service/metal-staining-you-need-a-pool-service/", "date": "2023-06-09T04:31:13Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-23/segments/1685224655247.75/warc/CC-MAIN-20230609032325-20230609062325-00065.warc.gz", "language_score": 0.9669878482818604, "token_count": 297, "dump": "CC-MAIN-2023-23", "global_id": "webtext-fineweb__CC-MAIN-2023-23__0__104901713", "lang": "en", "text": "If your pool surface has developed staining and you have confirmed it is not algae, you need to consider having Central Florida Pool Service maintain your backyard investment. Failure to remedy the situation in a timely manner may cost you thousands more than you would pay for weekly pool service.\nThe most common type of metal stain that we encounter is metal, specifically copper. Copper is found naturally in water and is magnified by copper water lines in your house, pool heater coils, copper algaecide, etc. Over time, the metal content in the water increases to the point that the metals attach to the pool surface and stains are visible.\nWe have found that many times the copper staining is due to improper pool service. Prior to hiring us for pool cleaning, residents informed us they would routinely administer copper algaecide in the pool. This was because they had algae outbreaks on a regular basis. That is when they should have called us to begin with!\nMore times than none we can properly identify the pool stain that you have and correct what is causing the staining. Whether we can remove the stain is dependent on many factors such as chemical damage, the age of the pool surface, amount of organic debris, how long the stain has been there, etc.\nThe wise solution is to have Central Florida Pool Service maintain your backyard investment prior to having irreversible damage due to improper pool service. Call us today at 863-853-2317!", "domain": "chemistry", "round": 3} +{"url": "https://www.oncotarget.com/article/9148/", "date": "2023-11-30T00:33:10Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100164.15/warc/CC-MAIN-20231130000127-20231130030127-00757.warc.gz", "language_score": 0.8641692996025085, "token_count": 616, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__112478427", "lang": "en", "text": "iCar-PseCp: identify carbonylation sites in proteins by Monte Carlo sampling and incorporating sequence coupled effects into general PseAAC\nMetrics: PDF 1292 views | HTML 3141 views | ?\nJianhua Jia1,2, Zi Liu3, Xuan Xiao1,2, Bingxiang Liu1, Kuo-Chen Chou2,4\n1Computer Department, Jing-De-Zhen Ceramic Institute, Jing-De-Zhen 333403 China\n2Gordon Life Science Institute, Boston, MA 02478, USA\n3School of Computer Science and Engineering, Nanjing University of Science and Technology, Nanjing, 210094, China\n4Center of Excellence in Genomic Medicine Research (CEGMR), King Abdulaziz University, Jeddah 21589, Saudi Arabia\nJianhua Jia, email: [email protected]\nXuan Xiao, email: [email protected]\nKuo-Chen Chou, email: [email protected]\nKeywords: carbonylation, sequence-coupling model, PseAAC, Monte Carlo sampling, random forest algorithm\nReceived: March 06, 2016 Accepted: April 09, 2016 Published: May 03, 2016\nCarbonylation is a posttranslational modification (PTM or PTLM), where a carbonyl group is added to lysine (K), proline (P), arginine (R), and threonine (T) residue of a protein molecule. Carbonylation plays an important role in orchestrating various biological processes but it is also associated with many diseases such as diabetes, chronic lung disease, Parkinson’s disease, Alzheimer’s disease, chronic renal failure, and sepsis. Therefore, from the angles of both basic research and drug development, we are facing a challenging problem: for an uncharacterized protein sequence containing many residues of K, P, R, or T, which ones can be carbonylated, and which ones cannot? To address this problem, we have developed a predictor called iCar-PseCp by incorporating the sequence-coupled information into the general pseudo amino acid composition, and balancing out skewed training dataset by Monte Carlo sampling to expand positive subset. Rigorous target cross-validations on a same set of carbonylation-known proteins indicated that the new predictor remarkably outperformed its existing counterparts. For the convenience of most experimental scientists, a user-friendly web-server for iCar-PseCp has been established at http://www.jci-bioinfo.cn/iCar-PseCp, by which users can easily obtain their desired results without the need to go through the complicated mathematical equations involved. It has not escaped our notice that the formulation and approach presented here can also be used to analyze many other problems in computational proteomics.\nAll site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.", "domain": "chemistry", "round": 3} +{"url": "https://www.routledge.com/Handbook-of-Active-Materials-for-Medical-Devices-Advances-and-Applications/Lantada/p/book/9789814303361", "date": "2020-12-02T22:53:02Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-50/segments/1606141716970.77/warc/CC-MAIN-20201202205758-20201202235758-00164.warc.gz", "language_score": 0.9227893352508545, "token_count": 665, "dump": "CC-MAIN-2020-50", "global_id": "webtext-fineweb__CC-MAIN-2020-50__0__157962207", "lang": "en", "text": "This book covers biodevices, mainly implantable or quirurgical, for the diagnosis or treatment of different pathologies, which benefit from the use of active materials as sensors or actuators. Such active or \"intelligent\" materials are capable of responding in a controlled way to different external physical or chemical stimuli by changing some of their properties. These materials can be used to design and develop sensors, actuators, and multifunctional systems with a large number of applications for developing biodevices and medical appliances.\nCurrent work on these fields entails problems related to synthesis, characterization, modeling, simulation, processing, and prototyping technologies, as well as device testing and validation, all of which are treated in depth in this book, for the several types of active or intelligent materials covered. The research presented in this book helps further development of medical devices, based on the additional functionalities that the use of active or \"intelligent\" materials, both as sensors and actuators, supplies. The main results exposed may help with the industrial expansion of this kind of materials as part of more complex systems.\nTable of Contents\nIntroduction to Product Development and Systematic Methodologies\nGeneral Considerations for Developing Medical Devices\nActive Materials in Medical Devices\nShape Memory Alloys for Biodevices\nShape Memory Polymers for Biodevices\nElectroactive Polymers as Actuators for Biodevices\nElectroactive Polymers as Sensors for Biodevices\nPyroelectric Materials for Biodevices\nActive Ceramics for Biodevices\nMagnetically Active Materials for Biodevices\nOptoactive and Photoactive Materials for Biodevices\nHydroactive Materials for Biodevices\nMicrostructured Active Materials in Biodevices\nNanostructured Active Materials in Biodevices\nNovel Techniques, Methods and Processes for Active Materials in Biodevices\nA Proposal for Structured Development Methodology\nAndres Diaz Lantada studied industrial engineering and specialized in mechanical engineering at the Universidad Politécnica de Madrid (UPM), Spain (www.upm.es). He obtained his Ph.D. in mechanical engineering in 2009 with a thesis on \"methodology for the structured development of medical devices based on active polymers.\" He has worked for 10 years as a researcher at this university’s Mechanical Engineering Department and collaborated actively with its Product Development Laboratory, in both research and teaching tasks. Currently he works as assistant professor at UPM and teaches subjects at both the graduate and postgraduate levels, as well as specialization courses. He is also actively engaged in conducting research on different areas related with product development. He has published more than 100 peer-reviewed scientific publications, several books and book chapters and is the co-inventor of 10 patents on the use of active materials for improving the sensing/actuating capabilities of medical products.\n\"This book is an excellent summary of the up-to-date knowledge on currently available and future active materials for medical applications. The research-oriented structure and content of the book makes it unique and one of a kind.\"\n—Prof. Emilio Bautista Paz - Universidad Politécnica de Madrid, Spain", "domain": "chemistry", "round": 3} +{"url": "http://kapli-rest.ru/write+notes+on+radiocarbon+dating/7305.html", "date": "2018-11-18T03:46:31Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-47/segments/1542039743963.32/warc/CC-MAIN-20181118031826-20181118053826-00532.warc.gz", "language_score": 0.930924654006958, "token_count": 350, "dump": "CC-MAIN-2018-47", "global_id": "webtext-fineweb__CC-MAIN-2018-47__0__143421285", "lang": "en", "text": "Luckily, we can measure these fluctuations in samples that are dated by other methods.\nTree rings can be counted and their radiocarbon content measured.\nThe principle of radiocarbon dating is simple: the rates at which various radioactive elements decay are known, and the ratio of the radioactive element to its decay products shows how long the radioactive element has existed in the rock.\nPaleontology seeks to map out how life evolved across geologic time.A substantial hurdle is the difficulty of working out fossil ages.Together with stratigraphic principles, radiometric dating methods are used in geochronology to establish the geological time scale.Beds that preserve fossils typically lack the radioactive elements needed for radiometric dating (\"radiocarbon dating\" or simply \"carbon dating\").Favoriting this resource allows you to save it in the “My Resources” tab of your account.\nThere, you can easily access this resource later when you’re ready to customize it or assign it to your students.\nRadioactive elements are common only in rocks with a volcanic origin, so the only fossil-bearing rocks that can be dated radiometrically are volcanic ash layers.\nCarbon dating uses the decay of carbon-14 to estimate the age of organic materials, such as wood and leather.\nRachel Wood does not work for, consult, own shares in or receive funding from any company or organisation that would benefit from this article, and has disclosed no relevant affiliations beyond the academic appointment above.\nRadiocarbon dating has transformed our understanding of the past 50,000 years.\nProfessor Willard Libby produced the first radiocarbon dates in 1949 and was later awarded the Nobel Prize for his efforts.", "domain": "chemistry", "round": 3} +{"url": "https://saemobilus.sae.org/content/2020-28-0425/", "date": "2020-09-28T19:58:04Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-40/segments/1600401604940.65/warc/CC-MAIN-20200928171446-20200928201446-00390.warc.gz", "language_score": 0.7060229778289795, "token_count": 1346, "dump": "CC-MAIN-2020-40", "global_id": "webtext-fineweb__CC-MAIN-2020-40__0__274346194", "lang": "en", "text": "This content is not included in your SAE MOBILUS subscription, or you are not logged in.\nThe Effect of TiB2 on Mechanical and Microstructural Properties of AZ91 Matrix Composites Manufactured by Cold Chamber Die Casting Process\nISSN: 0148-7191, e-ISSN: 2688-3627\nPublished September 25, 2020 by SAE International in United States\nThis content contains downloadable datasetsAnnotation ability available\nEvent: International Conference on Advances in Design, Materials, Manufacturing and Surface Engineering for Mobility\nIn these work AZ91 magnesium matrix composites reinforced with two weight fractions (5 and 10 wt. %) of TiB2 particulates were fabricated by cold chamber die casting process technique. The microstructure, density, hardness, mechanical properties of the specimens was investigated. Microstructure studies showed that fairly uniform distribution of reinforcements was achieved up to the weight fraction studied. As compared to base alloy AZ91, the hardness and tensile strength considerably increased with increasing reinforcement content. The presence of TiB2 particles improved the hardness around 24.4 %, compressive strength around 67.2% and the yield strength around 20%. The enormous amount of increment in the compressive strength due to the dislocation density created by the difference in thermal properties of matrix and composites and also due to the micro-pores presence in the composite.\nCitationR, S., P, P., and M, P., \"The Effect of TiB2 on Mechanical and Microstructural Properties of AZ91 Matrix Composites Manufactured by Cold Chamber Die Casting Process,\" SAE Technical Paper 2020-28-0425, 2020.\nData Sets - Support Documents\n|[Unnamed Dataset 1]|\n|[Unnamed Dataset 2]|\n- Gupta, M., and Sharon, N.M.L. , Magnesium, Magnesium Alloys, and Magnesium Composites (New Jersey: Wiley, 2011), 5.\n- Deng, K.K., Wu, K., Wu, Y.W. et al. , “Effect of Submicron Size SiC Particulates on Microstructure and Mechanical Properties of AZ91 Magnesium Matrix Composites,” J. Alloys Compd. 504:542-547, 2010.\n- Zheng, M.Y., Wua, K., Kamado, S., and Kojima, Y. , “Aging Behavior of Squeeze Cast SiC/AZ91 Magnesium Matrix Composite,” Mater. Sci. Eng. A 348:67-75, 2003.\n- Reyes, E.B., Perez, R., and Contreras, A. , “Effect of Heat Treatment on the Mechanical and Microstructural Characterization of Mg-AZ91E/TiC Composites,” Compos. Interfaces 24(6):593-609, 2017.\n- Zheng, M.Y., Wu, K., Liang, M. et al. , “The Effect of Thermal Exposure on the Interface and Mechanical Properties of Al 18B4O33w/AZ91 Magnesium Matrix Composite,” Mater. Sci. Eng. A 372:66-74, 2004.\n- Deng, K.K., Wang, X.J., Wu, Y.W. et al. , “Effect of Particle Size on Microstructure and Mechanical Properties of SiCp/AZ91 Magnesium Matrix Composite,” Mater. Sci. Eng. A 543:158-163, 2012.\n- Yu, W., Wang, X., Zhao, H. et al. , “Microstructure, Mechanical Properties and Fracture Mechanism of Ti AlC Reinforced AZ91D Composites Fabricated by Stir Casting,” J. Alloys Compd. 702:199-208, 2017.\n- Kandil , “Microstructure and Mechanical Properties of SiCp /AZ91 Magnesium Matrix Composites Processed by Stir Casting,” J. Eng. Sci., Assiut Univ 40(1):255-270, 2012.\n- Vinarcik, E.J. , High Integrity Die Casting Processes (New York: John Wiley & Sons, Inc., 2003).\n- Wong, W.L.E., Karthik, S., and Gupta, M. , “Development of High Performance Mg-Al2O3 Composites Containing Al2O3 in Submicron Length Scale Using Microwave Assisted Rapid Sintering,” Mater. Sci. Technol. 21(9):1063-1070, 2005.\n- Spierings, A.B., Schneider, M., and Eggenberger, R. , “Comparison of Density Measurement Techniques for Additive Manufactured Metallic Parts,” Rapid Prototyping J. 17(5):380-386, 2011.\n- Wang, H.Y., Jiang, Q.C., and Wang, Y. , “Fabrication of TiB2 Particulate Reinforced Magnesium Matrix Composites by Powder Metallurgy,” Mater. Lett. 58:3509-3513, 2004.\n- Xiao-Peng, C., Hai-Feng, L., Jian, M., and De-Ping, Z. , “Microstructure and Mechanical Properties of Die-Cast AZ91 D Magnesium Alloy by Pr Additions,” s435-s438 Jan. 2010\n- Cerri, E., Leo, P., and De Marco, P.P. , “Hot Compression Behaviour of the AZ91 Magnesium Alloy Produced by High Pressure DIE Casting,” 189(2007):97-106, Jan. 2007.\n- Braszczynska-Malik, K.N., Zawadzki, I., Walczak, W., and Braszczynski, J. , “Mechanical Properties of High-Pressure Die-Casting AZ91 Magnesium Alloy,” 8(4), July 2008.\n- Yinghong, P., Dayong, L., Wang, Y., Jilong, Y. et al. , “Numerical Study on the Low Pressure Die Casting of AZ91D Wheel Hub” Materials Science Forum 488-489, Aug. 2005, ISSN: 1662-9752.", "domain": "chemistry", "round": 3} +{"url": "https://www.ars.usda.gov/research/publications/publication/?seqNo115=87954", "date": "2023-10-04T05:42:27Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233511361.38/warc/CC-MAIN-20231004052258-20231004082258-00628.warc.gz", "language_score": 0.9354794025421143, "token_count": 802, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__74302312", "lang": "en", "text": "Submitted to: International Soil Science Society Conference Proceedings\nPublication Type: Proceedings\nPublication Acceptance Date: 8/26/1998\nPublication Date: N/A\nInterpretive Summary: Current soil testing methods are generally unable to distinguish between complex chemical effects of closely related elements. An example is phosphorus (P) and vanadium (V). Phosphorus, an essential nutrient element for all life forms, is taken up by plants. Vanadium, while common in soil, is usually present in concentrations much less than that of P. Most soil tests ignore V because no previous evidence existed of its importance to crop production. The chemical forms of both, as they exist in the soil, are similar. A new extraction device, developed at the USDA-ARS North Central Soil Conservation Research Laboratory, permits extraction of up to 20 elements simultaneously from the soil. Use of this test, along with field studies, showed that the presence of vanadium may interfere with the plant's uptake of phosphorus even when soils are moderately rich in phosphorus, thus depressing yields of some soybean varieties by as much as 10 bushels per acre. This new soil test can enable producers to determine if V is likely to be a problem for soybean production. These data also provide guidelines to assist the producers in adjusting either their phosphorous fertilizer practices and/or soybean seed variety selection to reduce the risks and costs of production.\nTechnical Abstract: Methods of soil evaluation often limit the number of elements which can be quantified from a single extract. This constraint obscures subtle and complex interactions between nutrient elements and plant genotypes. A complex interaction of phosphorus(P)and vanadium(V)on soybean seed yield was identified using resin extraction techniques in a wheat (Triticum aestivum L.)-soybean-maize(Zea mays L.)rotation on the Swan Lake Res. Farm near Morris, MN. Soils were Barnes loam(Udic Haploboroll),Hamerly clay loam (Aeric Calciaquoll), Parnell silty clay loam (Typic Argiaquoll), Buse loam (Udothentic Haploboroll), and Svea loam (Udic Haploboroll ). Each rotation consisted of 360 plots measuring 3 m by 10 m. Soybean was planted in strips containing 30 consecutive plots. Seeds were planted in rows spaced at 0.75 m intervals at a rate of 65 seeds m**-2. Pioneer Brand seed 9061 and 9091 were planted in 1995 and 1996. Cenex Brand variety 704 was also planted in 1996. Soil samples were collected during the summer, dried, crushed and passed through a 2.0 mm sieve. Soil samples(6 g)were suspended in 20%(v/v) methanol and equilibrated with ion exchange resins. After equilibration, resins were eluted and analyzed directly using ICP methods. Data on extractable chemistries were analyzed using SAS PROC GLM procedures. Soils differed in NaHCO3 extractable P, resin extractable (RE)-P, and RE-V. Seed yields varied from 2.65 to 3.60 Mg ha**-1 but were positively correlated with RE-P or HCO-3 extractable P. Seed yields were negatively correlated with extractable V for Pioneer 9061 and Cenex 704; Pioneer 9061 was unaffected by extractable V. A complex RE-P by RE-V interaction affected seed yield. Non-resin techniques for chemical evaluation of soil are generally unable to identify these complex relationships.", "domain": "chemistry", "round": 3} +{"url": "https://www.sciencehq.com/chemistry/freundlich-adsorption-isotherm.html", "date": "2020-12-03T03:37:01Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-50/segments/1606141718314.68/warc/CC-MAIN-20201203031111-20201203061111-00398.warc.gz", "language_score": 0.8638222217559814, "token_count": 271, "dump": "CC-MAIN-2020-50", "global_id": "webtext-fineweb__CC-MAIN-2020-50__0__100806375", "lang": "en", "text": "Freundlich Adsorption Isotherm\nFreundlich Adsorption Isotherm:\nAccording to him:\n(i) At low pressure:\nAt low pressure the graph is almost\nWhere, K = constant\n(ii) At high pressure:\nx / m becomes almost constant and does not change with pressure\n(iii) At intermediate value of pressure.\nHere ‘n’ is a constant depending upon nature of adsorbate and adsorbent.\nThe value of K, n can be determined as follows: On taking logarithm of equation (1) we get\nThus, on plotting a graph between x/ m and logep a straight line is obtained.\n- Factors Affecting Adsorption Adsorption of gases on solid surface depends upon: (1) Nature...\n- Absorption Isotherm worksheet Absorption Isotherm is the process of studying adsorption with the...\n- Formulas of Gaseous State Boyle’s law, (At constant temperature) Charle’s law; Gas...\n- Adsorption The phenomenon of adsorption was introduced by Scheele during the...\n- The Gas Equation If Boyle’s and Charle’s law are combined, then PV =...", "domain": "chemistry", "round": 3} +{"url": "http://www.origene.com/antibody/TA303654.aspx", "date": "2014-09-19T04:43:52Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2014-41/segments/1410657130067.43/warc/CC-MAIN-20140914011210-00174-ip-10-196-40-205.us-west-1.compute.internal.warc.gz", "language_score": 0.8467776775360107, "token_count": 722, "dump": "CC-MAIN-2014-41", "global_id": "webtext-fineweb__CC-MAIN-2014-41__0__82016801", "lang": "en", "text": "Home Antibody All anti-PRKAA1 antibodies\nAnti-PRKAA1 Antibody Y365\nAlso for PRKAA1 (NM_006251)\n|A synthetic peptide corresponding to residues near the C-term of human AMPK alpha-1 subunit was used as an immunogen|\n|Mouse, Rat, Human\n||Lot dependent; please refer to CoA along with shipment\n|WB, IHC, FC\n||FC: 1:100; WB: 1:1000 - 1:5000; IHC-P: 1:100 - 1:250; IP: 1:50\n|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|\n|Is unsuitable for ICC/IF.\n|Homo sapiens protein kinase, AMP-activated, alpha 1 catalytic subunit (PRKAA1), transcript variant 1|\n|The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq]. |\n* Availability is in business days\n* OriGene provides validated application data and protocol, with money back guarantee.\nWestern blot - AMPK alpha 1 antibody [Y365]; All lanes : Anti-AMPK alpha 1 antibody [Y365] at 1/5000 dilution.Lane 1 : MCF-7.Lane 2 : Hela.Predicted band size : 63 kDa.Observed band size : 63 kDa.\nImmunohistochemistry (Paraffin-embedded sections) - AMPK alpha 1 antibody [Y365]; TA303654 at a 1:100 - 1:250 dilution staining AMPK alpha 1 in Human cervical carcinoma, using Immunohistochemistry, Paraffin Embedded Tissue.\nFlow Cytometry - Anti-AMPK alpha 1 antibody [Y365]; Overlay histogram showing HeLa cells stained with TA303654 (red line). The cells were fixed with 80% methanol (5 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody for 30 min at 22°C. The secondary antibody used was DyLight 488 goat anti-rabbit IgG (H+L) at 1/500 dilution for 30 min at 22°C. Isotype control antibody (black line) was rabbit IgG (monoclonal) (1ug/1x10^6 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter.", "domain": "chemistry", "round": 3} +{"url": "https://www.hardinscientific.com/blogs/news/biorxiv-subject-collection-all", "date": "2021-10-21T06:44:44Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-43/segments/1634323585381.88/warc/CC-MAIN-20211021040342-20211021070342-00071.warc.gz", "language_score": 0.9105142951011658, "token_count": 305, "dump": "CC-MAIN-2021-43", "global_id": "webtext-fineweb__CC-MAIN-2021-43__0__33607812", "lang": "en", "text": "Post-translational modifications on histones can be stable epigenetic marks and transient signals that can occur in response to internal and external stimuli. Levels of histone modifications fluctuate during the cell cycle and vary among different cell types. Here we describe a simple system to monitor the levels of multiple histone modifications in single cells by multicolor immunofluorescence using directly labeled modification-specific antibodies. We first analyzed histone H3 and H4 modifications during the cell cycle. Levels of active marks, such as acetylation and H3K4 methylation, were increased during the S phase, in association with chromatin duplication. By contrast, levels of some repressive modifications gradually increased during the G2 and the next G1 phases. We applied this method to validate the target modifications of various histone demethylases in cells using a transient overexpression system. We also screened chemical compounds in marine organism extracts that affect histone modifications and identified psammaplin A, which was previously reported to inhibit histone deacetylases. Thus, the method presented here is a powerful and convenient tool for analyzing the changes in histone modifications. It is made available under a CC-BY-NC-ND 4.0 International license .\nAlso in Industry News\nHow to decide whether or not to start treatment for prostate cancer?\nAnalysis of the SARS-CoV-2 proteome via visual tools\n$65m investment increases British Patient Capital’s exposure to life sciences and health technology", "domain": "chemistry", "round": 3} +{"url": "https://www.mysciencework.com/publication/show/8d71c878f570b05099efa28a8d2d301e", "date": "2017-03-28T15:55:00Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-13/segments/1490218189802.18/warc/CC-MAIN-20170322212949-00647-ip-10-233-31-227.ec2.internal.warc.gz", "language_score": 0.9207923412322998, "token_count": 339, "dump": "CC-MAIN-2017-13", "global_id": "webtext-fineweb__CC-MAIN-2017-13__0__134817914", "lang": "en", "text": "Abstract The purpose of this study was to examine the placental passage of ritodrine hydrochloride in relation to the drug's effects on the fetal circulation. Studies were carried out on nine nulliparous pregnant (120–140 days) ewes with chronically implanted cannulae for measurements of maternal and fetal arterial pressures and for blood sampling. One group of animals received sequential infusions of doses ranging from 0.1 to 30 μg/kg per min for 30 min (group 1). A second group was given a constant infusion of the drug at a dose of 3.0 μg/kg per min for 4 h (group 2). The peak concentrations of ritodrine in maternal and fetal blood were determined by radioimmunoassay. In group 1 they were 313.4 ± 24.1 ng/ml (mean ± S.E.) and 12.6 ± 3.7 ng/ml at the finish of 30.0 μg/kg per min infusion for maternal and fetal blood, respectively. In group 2, maternal drug levels were 81.3 ± 20.4 ng/ml after 30 min and 95.9 ± 17.1 ng/ml after 4 h of the infusion. Fetal plasma concentrations increased slowly from trace levels at 30 min to 3.3 ± 0.7 ng/ml at 4 h. Fetal blood pressure and heart rate did not show any significant changes during and after the infusion of ritodrine in both treatment groups. Our findings demonstrate the maternal administration of ritodrine produces no significant effects on the circulatory system of the fetal lamb because of the low transplacental passage of this drug.", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/mosc2-antibody-ab224398.html", "date": "2020-10-26T01:45:42Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-45/segments/1603107890108.60/warc/CC-MAIN-20201026002022-20201026032022-00099.warc.gz", "language_score": 0.7497014403343201, "token_count": 499, "dump": "CC-MAIN-2020-45", "global_id": "webtext-fineweb__CC-MAIN-2020-45__0__118039804", "lang": "en", "text": "Key features and details\n- Rabbit polyclonal to MOSC2\n- Suitable for: IHC-P\n- Reacts with: Human\n- Isotype: IgG\nProduct nameAnti-MOSC2 antibody\nSee all MOSC2 primary antibodies\nDescriptionRabbit polyclonal to MOSC2\nTested applicationsSuitable for: IHC-Pmore details\nSpecies reactivityReacts with: Human\nPredicted to work with: Cynomolgus monkey\n- IHC: Human liver tissue.\nStorage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.\nStorage bufferpH: 7.20\nPreservative: 0.02% Sodium azide\nConstituents: 40% Glycerol (glycerin, glycerine), PBS\nConcentration information loading...\nPurityImmunogen affinity purified\nOur Abpromise guarantee covers the use of ab224398 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\n|IHC-P||1/50 - 1/200. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.|\nFunctionCatalytic component of the benzamidoxime prodrug-converting complex, a complex required to reduce N-hydroxylated structures, such as benzamidoxime prodrug. Benzamidoxime is an amidine prodrug produced by N-hydroxylation which is used to enhance bioavailability and increase intestinal absorption. It is then reduced into benzamidine, its active amidine, by the benzamidoxime prodrug-converting complex.\nSequence similaritiesContains 1 MOSC domain.\nCellular localizationMitochondrion outer membrane.\n- Information by UniProt\n- FLJ20605 antibody\n- MARC2 antibody\n- Mitochondrial amidoxime reducing component 2 antibody\nTo our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.\nab224398 has not yet been referenced specifically in any publications.", "domain": "chemistry", "round": 3} +{"url": "https://berstructuralbioportal.org/highlight/key-drug-target-shown-assembling-in-real-time/", "date": "2022-01-18T05:29:49Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-05/segments/1642320300722.91/warc/CC-MAIN-20220118032342-20220118062342-00562.warc.gz", "language_score": 0.8205064535140991, "token_count": 305, "dump": "CC-MAIN-2022-05", "global_id": "webtext-fineweb__CC-MAIN-2022-05__0__48929501", "lang": "en", "text": "Key Drug Target Shown Assembling in Real Time\nThe activation of G proteins by G protein-coupled receptors (GPCRs) underlies the majority of transmembrane signaling by hormones and neurotransmitters.\nIn an effort to better understand the structural basis of coupling specificity, researchers used time-resolved structural mass spectrometry techniques to investigate GPCR-G protein complex formation and G-protein activation. The techniques revealed the timeline for different parts of GPCR interacting with its signaling partners.\nThe results suggest that coupling specificity is determined by one or more transient intermediate states that serve as selectivity filters and precede the formation of the stable nucleotide-free GPCR-G protein complexes observed in crystal and cryo-EM structures.\nY. Du, N. M. Duc, S. G.F. Rasmussen, D. Hilger, X. Kubiak, L. Wang, J. Bohon, H. R. Kim, M. Wegrecki, A. Asuru, K. M. Jeong, J. Lee, M. R. Chance, D. T. Lodowski, B. K. Kobilka, K. Y. Chung, “Assembly of a GPCR-G Protein Complex,” Cell 177:5 1232-1242 (2019). [DOI: 10.1016/j.cell.2019.04.022]", "domain": "chemistry", "round": 3} +{"url": "https://petrotek.ae/lubricants/grease-/180/grease", "date": "2023-05-29T19:43:38Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-23/segments/1685224644907.31/warc/CC-MAIN-20230529173312-20230529203312-00255.warc.gz", "language_score": 0.9497941732406616, "token_count": 340, "dump": "CC-MAIN-2023-23", "global_id": "webtext-fineweb__CC-MAIN-2023-23__0__180875772", "lang": "en", "text": "Greases are classed chiefly by their thickeners, the most prevalent of which are metallic soaps. Bentonite clay, silica gel, polyurea, and inorganic thickeners are also included. New grease-lubricated machinery has been created in recent years, with grease technology providing much lower friction and extended grease life.\nWhy are greases used?\nWhen oil is not practicable or handy, grease is utilized. The role of grease is to stay in touch with moving surfaces and lubricate them without leakage under gravity, centrifuge action, or pressure. Its primary technical need is that it preserves its characteristics at all temperatures during usage under shear forces.\nMachinery that is difficult to lubricate regularly. For lengthy periods and without regular refilling, high-quality grease can lubricate remote or relatively inaccessible components. These greases are also employed in life-saving applications like some electric motors and transmission systems.\nGrease can improve the performance of degraded parts originally lubricated with oil by maintaining thicker layers in clearances expanded by wear.\nGrease produces thicker coating in wear-enhanced clearances and can prolong the service life of earlier oil-lubricated worn elements.\nIn the present time, the industries demand high-performance grease that provides accurate lubrication. Therefore, we can sustain the demands of the various industries by following a complete and workable approach.\nPetrotek, a grease supplier in UAE, is a proud name in the lubrication industry. We are serving the impeccable Grease service for more than a decades for all sizes of industries globally. Our team has accomplished 3000+ lubrication projects regionally and internationally.", "domain": "chemistry", "round": 3} +{"url": "https://www.mdpi.com/2218-1989/9/5/101", "date": "2019-06-26T16:11:25Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-26/segments/1560628000367.74/warc/CC-MAIN-20190626154459-20190626180459-00141.warc.gz", "language_score": 0.6850001215934753, "token_count": 786, "dump": "CC-MAIN-2019-26", "global_id": "webtext-fineweb__CC-MAIN-2019-26__0__194379656", "lang": "en", "text": "A Comprehensive Plasma Metabolomics Dataset for a Cohort of Mouse Knockouts within the International Mouse Phenotyping Consortium\nAbstractMouse knockouts facilitate the study ofgene functions. Often, multiple abnormal phenotypes are induced when a gene is inactivated. The International Mouse Phenotyping Consortium (IMPC) has generated thousands of mouse knockouts and catalogued their phenotype data. We have acquired metabolomics data from 220 plasma samples from 30 unique mouse gene knockouts and corresponding wildtype mice from the IMPC. To acquire comprehensive metabolomics data, we have used liquid chromatography (LC) combined with mass spectrometry (MS) for detecting polar and lipophilic compounds in an untargeted approach. We have also used targeted methods to measure bile acids, steroids and oxylipins. In addition, we have used gas chromatography GC-TOFMS for measuring primary metabolites. The metabolomics dataset reports 832 unique structurally identified metabolites from 124 chemical classes as determined by ChemRICH software. The GCMS and LCMS raw data files, intermediate and finalized data matrices, R-Scripts, annotation databases, and extracted ion chromatograms are provided in this data descriptor. The dataset can be used for subsequent studies to link genetic variants with molecular mechanisms and phenotypes. View Full-Text\n- Supplementary File 1:\nZIP-Document (ZIP, 7068 KB)\nShare & Cite This Article\nBarupal, D.K.; Zhang, Y.; Shen, T.; Fan, S.; Roberts, B.S.; Fitzgerald, P.; Wancewicz, B.; Valdiviez, L.; Wohlgemuth, G.; Byram, G.; Choy, Y.Y.; Haffner, B.; Showalter, M.R.; Vaniya, A.; Bloszies, C.S.; Folz, J.S.; Kind, T.; Flenniken, A.M.; McKerlie, C.; Nutter, L.M.J.; Lloyd, K.C.; Fiehn, O. A Comprehensive Plasma Metabolomics Dataset for a Cohort of Mouse Knockouts within the International Mouse Phenotyping Consortium. Metabolites 2019, 9, 101.\nBarupal DK, Zhang Y, Shen T, Fan S, Roberts BS, Fitzgerald P, Wancewicz B, Valdiviez L, Wohlgemuth G, Byram G, Choy YY, Haffner B, Showalter MR, Vaniya A, Bloszies CS, Folz JS, Kind T, Flenniken AM, McKerlie C, Nutter LMJ, Lloyd KC, Fiehn O. A Comprehensive Plasma Metabolomics Dataset for a Cohort of Mouse Knockouts within the International Mouse Phenotyping Consortium. Metabolites. 2019; 9(5):101.Chicago/Turabian Style\nBarupal, Dinesh K.; Zhang, Ying; Shen, Tong; Fan, Sili; Roberts, Bryan S.; Fitzgerald, Patrick; Wancewicz, Benjamin; Valdiviez, Luis; Wohlgemuth, Gert; Byram, Gregory; Choy, Ying Y.; Haffner, Bennett; Showalter, Megan R.; Vaniya, Arpana; Bloszies, Clayton S.; Folz, Jacob S.; Kind, Tobias; Flenniken, Ann M.; McKerlie, Colin; Nutter, Lauryl M.J.; Lloyd, Kent C.; Fiehn, Oliver. 2019. \"A Comprehensive Plasma Metabolomics Dataset for a Cohort of Mouse Knockouts within the International Mouse Phenotyping Consortium.\" Metabolites 9, no. 5: 101.", "domain": "chemistry", "round": 3} +{"url": "https://www.omicsonline.org/references/multiple-nsaidinduced-hits-injure-the-small-intestine-underlying-mechanisms-and-novel-strategies-259497.html", "date": "2017-09-25T17:10:50Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-39/segments/1505818692236.58/warc/CC-MAIN-20170925164022-20170925184022-00222.warc.gz", "language_score": 0.910467267036438, "token_count": 418, "dump": "CC-MAIN-2017-39", "global_id": "webtext-fineweb__CC-MAIN-2017-39__0__19634712", "lang": "en", "text": "Author(s): Boelsterli UA, Redinbo MR, Saitta KS\nAbstract Share this page\nAbstract Nonsteroidal anti-inflammatory drugs (NSAIDs) can cause serious gastrointestinal (GI) injury including jejunal/ileal mucosal ulceration, bleeding, and even perforation in susceptible patients. The underlying mechanisms are largely unknown, but they are distinct from those related to gastric injury. Based on recent insights from experimental models, including genetics and pharmacology in rodents typically exposed to diclofenac, indomethacin, or naproxen, we propose a multiple-hit pathogenesis of NSAID enteropathy. The multiple hits start with an initial pharmacokinetic determinant caused by vectorial hepatobiliary excretion and delivery of glucuronidated NSAID or oxidative metabolite conjugates to the distal small intestinal lumen, where bacterial β-glucuronidase produces critical aglycones. The released aglycones are then taken up by enterocytes and further metabolized by intestinal cytochrome P450s to potentially reactive intermediates. The \"first hit\" is caused by the NSAID and/or oxidative metabolites that induce severe endoplasmic reticulum stress or mitochondrial stress and lead to cell death. The \"second hit\" is created by the significant subsequent inflammatory response that would follow such a first-hit injury. Based on these putative mechanisms, strategies have been developed to protect the enterocytes from being exposed to the parent NSAID and/or oxidative metabolites. Among these, a novel strategy already demonstrated in a murine model is the selective disruption of bacteria-specific β-glucuronidases with a novel small molecule inhibitor that does not harm the bacteria and that alleviates NSAID-induced enteropathy. Such mechanism-based strategies require further investigation but provide potential avenues for the alleviation of the GI toxicity caused by multiple NSAID hits.\nThis article was published in Toxicol Sci\nand referenced in Pharmaceutica Analytica Acta", "domain": "chemistry", "round": 3} +{"url": "https://futurefibreshub.com.au/publications/page/14/", "date": "2021-07-30T05:22:35Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-31/segments/1627046153931.11/warc/CC-MAIN-20210730025356-20210730055356-00115.warc.gz", "language_score": 0.726058840751648, "token_count": 350, "dump": "CC-MAIN-2021-31", "global_id": "webtext-fineweb__CC-MAIN-2021-31__0__78831374", "lang": "en", "text": "The Hub has developed a Vision Document on fibres materials – their application and potential future research directions. For more information please visit here.\nHub researchers have published over 90 journal publications across various fibre fields. The full list is below.\n|2016||Comparative acoustic performance and mechanical properties of silk membranes for the repair of chronic tympanic membrane perforations||B.J. Allardyce, R. Rajkhowa, R.J. Dilley, Z. Xie, L. Campbell, A. Keating, M.D. Atlas, M. Von Unge, X. Wang||Journal of the Mechanical Behavior of Biomedical Materials||View|\n|2016||Controlling the supramolecular architecture of molecular gels with surfactants||J.Y. Chen, B. Yuan, Z.Y. Li, B. Tang, E. Ankers, X.G. Wang, J.L. Li||Langmuir||View|\n|2016||Interactions between fibroin and sericin proteins from Antheraea pernyi and Bombyx mori silk fibers||S. Du, J. Zhang, W.T. Zhou, Q.X. Li, G.W. Greene, H.J. Zhu, J.L. Li, X.G. Wang||Journal of Colloid and Interface Science||View|\n|2016||Synergistic coassembly of two structurally different molecular gelators||J.Y. Chen, B. Yuan, Z.Y. Li, B. Tang, A. Gupta, S-V. Bhosale, J.L. Li||Langmuir||View|", "domain": "chemistry", "round": 3} +{"url": "http://bfsdatinggk.billigparajumpersjakkesalgpjsnorge.xyz/fire-extinguisher-halon-msds-sheet.html", "date": "2019-12-13T00:16:44Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-51/segments/1575540547536.49/warc/CC-MAIN-20191212232450-20191213020450-00127.warc.gz", "language_score": 0.6833432912826538, "token_count": 973, "dump": "CC-MAIN-2019-51", "global_id": "webtext-fineweb__CC-MAIN-2019-51__0__52698731", "lang": "en", "text": "Fire extinguisher halon msds sheet\nHome Emergency & Safety Fire Extinguishers Halon Fire Extinguishers H3R Aviation fire Model C352TS - Halon 1211 Fire Extinguisher. Material Safety msds Data Sheet: MSDS1. The terms standards, reports , codes of msds practice, definitions are drawn from a fire number of sources including legislation, guides other extinguisher documents. The following is a halon glossary of some key terms acronyms used on this , concepts fire other associated websites. IDENTIFICATION Product Name ( msds Fire extinguisher Extinguishing halon Agent with Expellant) FM- 200® Other Names Heptafluoropropane HFC- 227ea Recommended halon use of the chemical restrictions on use Identified uses Fire Extinguishing Agent.\nAvoid release to sheet the fire environment. msds MATERIAL SAFETY DATA SHEET Halon 1301 ( Fire Extinguishing Agent) Revision Date: February 9, Page 1 of 6 1. Fire extinguisher halon msds sheet. CH 502/ 504/ 534 ( Foam Portable & Wheeled) English. Click the links on this page to download. Fire Fighting Measures. applications as a substitute for halon 1211 ( bromochlorodifluoromethane or \" BCF\" ). Fire Extinguisher Training;. Our location is open sheet to the Public.\n2654 NW Market Street Seattle WA 98107 USA. Avoid contact with eyes msds skin clothing. Halotron I sheet Safety Data Sheet. : Incoming_ SDS_ Halon 1301_ 00 SDS DATE: January PAGE 5 OF msds halon 5. Refer to special instructions/ safety data sheet. Material Safety halon fire Data Sheet. sheet 8: 00 AM – 4: 30 PM. Use extinguishing agent suitable for type. SAFETY DATA SHEET Product: Spherical Titanium Powder ( Fine) Print Date MSDS Document Number Page 2 of 6 February 25 smother with dry sand, CPTI- A- 04- msds E ( 5) FIRE- FIGHTING MEASURES Suitable extinguishing media: Use sheet halon approved extinguisher Class D extinguisher extinguisher dry clay MATERIAL halon SAFETY DATA SHEET ABC Fire Extinguisher Issue Date:. IDENTIFICATION extinguisher OF THE SUBSTANCE/ PREPARATIONS AND OF THE COMPANY UNDERTAKING Product Name Halon 1301 ( Fire Extinguishing Agent) Other Trade msds Names extinguisher Bromotrifluoromethane Product extinguisher halon Description Fire Extinguishing Agent. MSDS msds CANADA 1 / 4. hazard rating trojan battery company lead / acid battery sheet material safety data sheet section 1- - sheet chemical fire product and company identification manufacturer' s. Interior Extinguishers:.\nMONTHLY FIRE EXTINGUISHER CHECKLIST The following items shall be checked msds on all fire extinguishers at the facility halon and documented. HALON 1211 H3R Clean Agents Halon 1211 Page 1 of 13 SAFETY DATA SHEET Prepared to U. Fire extinguisher halon msds sheet. Exposure controls/ personal protection sheet Ingredient name Exposure limits. Empty containers retain product residue and can be hazardous. intended to apply to use of a fire.\nSAFETY DATA SHEET FM- 200® ( Fire Extinguishing Agent with Expellant) Revision Date: April 10, Page 1 of 8 1. : Precautions for safe handling Bromochlorodifluoromethane None. CH 506 ANTI- FREEZE CHARGE. If there is a fire extinguisher on site that does not pass the monthly inspection, notify the safety department immediately. Material Safety Data Sheets by County- Fire Protection. Product Use: Aircraft Fire fire Extinguishers. HALON WITH NITROGEN UN1956 MSDS- APRIL.\nMATERIAL SAFETY DATA SHEET ABC Fire Extinguisher Issue Date:. Product and Company Identification. pH Not available. HALON 1301 H3R Clean Agents Halon 1301 Page 1 of 13 SAFETY DATA SHEET Prepared to U. OSHA, CMA, ANSI, Canadian WHMIS Standards, European Union CLP EC 1272/, REACH and the Global Harmonization Standard 1.\nfire extinguisher halon msds sheet\nSECTION 1 – IDENTIFICATION OF THE SUBSTANCE/ MIXTURE AND OF THE COMPANY/ UNDERTAKING IDENTIFICATION of the SUBSTANCE or PREPARATION:. OR – If packaged as a charged Fire Extinguisher.", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/hrg-antibody-ab198920.html", "date": "2020-08-08T09:20:27Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-34/segments/1596439737319.74/warc/CC-MAIN-20200808080642-20200808110642-00221.warc.gz", "language_score": 0.7710012197494507, "token_count": 466, "dump": "CC-MAIN-2020-34", "global_id": "webtext-fineweb__CC-MAIN-2020-34__0__17638873", "lang": "en", "text": "Key features and details\n- Rabbit polyclonal to HRG\n- Suitable for: IHC-P\n- Reacts with: Human\n- Isotype: IgG\nProduct nameAnti-HRG antibody\nSee all HRG primary antibodies\nDescriptionRabbit polyclonal to HRG\nTested applicationsSuitable for: IHC-Pmore details\nSpecies reactivityReacts with: Human\nSynthetic peptide corresponding to Human HRG (internal sequence). NP_000403\nDatabase link: P04196\n- Human breast cancer and ovarian cancer tissues.\nStorage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.\nStorage bufferpH: 7.30\nPreservative: 0.05% Sodium azide\nConstituents: 49% PBS, 50% Glycerol\nConcentration information loading...\nPurityImmunogen affinity purified\nOur Abpromise guarantee covers the use of ab198920 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\n|IHC-P||1/50 - 1/200.|\nRelevanceHRG (histidine-rich glycoprotein) contains two cystatin-like domains and is located in plasma and platelets. The physiological function is not yet known. It binds heme, dyes and divalent metal ions. It can inhibit rosette formation and interacts with heparin, thrombospondin, and the lysine-binding site of plasminogen. A potential prothrombotic effect of HRG is indicated by the inhibition of fibrinolysis and the reduction of inhibition of coagulation. Mutations in HRG lead to thrombophilia due to abnormal histidine-rich glycoprotein levels.\n- DKFZp779H1622 antibody\n- Histidine proline rich glycoprotein antibody\n- Histidine rich glycoprotein antibody\nab198920 has not yet been referenced specifically in any publications.", "domain": "chemistry", "round": 3} +{"url": "https://www.aging-us.com/figure/203050/f6", "date": "2021-10-23T23:51:08Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-43/segments/1634323585828.15/warc/CC-MAIN-20211023224247-20211024014247-00036.warc.gz", "language_score": 0.8494223356246948, "token_count": 276, "dump": "CC-MAIN-2021-43", "global_id": "webtext-fineweb__CC-MAIN-2021-43__0__36566483", "lang": "en", "text": "Figure 6. Effects of κ-OR stimulation on β-GP-induced mineralization in aortic rings from rats. (A) Representative Alizarin red-stained sections of aortic rings from rats; Scale bar = 500 μm (above panel) and 100 μm (below panel). (B) Quantification of mineralization in the aortic rings using the O-cresol phthalein complex one assay. Aortic rings from rats were incubated in control medium (Con; serum-free DMEM), phosphate medium (β-GP; serum-free DMEM + 10 mmol/L β-GP), phosphate medium + U50,488H (40 mmol/L), or phosphate medium + nor-BNI (80 mmol/L) + U50,488H (40 mmol/L) for ten days. U, U50,488H; β-GP, β-Glycerophosphate disodium salt pentahydrate; N, nor-BNI; Data are shown as mean ± SEM and were analyzed using one-way ANOVA tests. n = 4 in each group. *P < 0.05 versus the control group, #P < 0.05 versus the β-GP group, $P < 0.05 versus the β-GP+U group.", "domain": "chemistry", "round": 3} +{"url": "https://jcesc.um.ac.ir/article_38079.html", "date": "2022-01-24T11:57:50Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-05/segments/1642320304528.78/warc/CC-MAIN-20220124094120-20220124124120-00067.warc.gz", "language_score": 0.6750791668891907, "token_count": 2583, "dump": "CC-MAIN-2022-05", "global_id": "webtext-fineweb__CC-MAIN-2022-05__0__27222478", "lang": "en", "text": "1. Ahmad, M., Zahir, Z. A., Khalid, M., Nazli, F., and Arshad, M. 2013. Efficacy of rhizobium and pseudomonas strains to improve physiology, ionic balance and quality of mung bean under salt-affected conditions on farmer’s fields. Plant Physiology and Biochemistry 63: 170-176.\n2. Altaf, A., Ishrat, K., and Abdin, M. Z. 2000. Effect of sulfur fertilization on oil accumulation, acetyl co-A concentration, and acetyl co-A carboxylase activity in the developing seeds of rapeseed (Brassica compestris L.). Australian Journal of Agricultural Research 51: 1023-1029.\n3. Anonymous, 1987. Approved Methods of the AACC. Method 11-46, American Association of Chemists Inc. St Paul, MN, USA.\n4. Arancon, N. Q., Edwards, C. A., Bierman, P., Welch, C., and Metzger, J. D. 2004. Influences of vermicomposts on field strawberries: 1. Effects on growth and yields. Bioresource Technology 93: 145-153.\n5. Besharaty, H., and Malekzadeh, T. 2015. Effect of sulfur and thiobacillus on soybean growth and uptake of some nutrients in four calcareous soils with different buffering capacities. Iranian Journal of Soil Research 29 (2): 131- 145. (in Persian with English abstract).\n6. Bremness, L. 1999. Herbs. Eyewitness Handbook. London.\n7. Dorado, J., Zancada, M. C., Almendros, G., and Lopez-Fando, C. 2003. Changes in soil properties and humic substances after longterm amendments with manure and crop residues in dry land farming systems. Journal of Plant Nutrition and Soil Science 166: 31-38.\n8. Eichler-Lobermann, B., Kohne, S., and Koppen, D. 2007. Effect of organic, inorganic and combined organic and inorganic P fertilization on plant P and soil P pools. Journal of Plant Nutrition and Soil Science 170: 623-628.\n9. El-Dewiny, C. Y., Moursy, Kh. S., and. El-Aila, H. I. 2006. Effect of organic matter on the release and availability of phosphorus and their effects on spainch and radish plants. Research Journal of Agriculture and Biological Sciences 2(3): 103-108.\n10. Erdal, I., Kepenek, K., and Kızılgoz, I. 2004. Effect of foliar iron applications at different growth stages on iron and some nutrient concentrations in strawberry cultivars. Turk Journal Agriculture Forest 28:421-427.\n11. Fankem, H., Ngo Nkot, L., Deubel, A, Quinn, J., Merbach, W., and Etoa, F. X. 2008. Solubilization of inorganic phosphates and plant growth promotion by strains of Pseudomonas fluorescens isolated from acidic soils of Cameroon. African Journal of Microbiology Research 2: 171-178.\n12. Graeme, J. B., Rod, B. L., Dana, M., and Anderson, G. C. 1993. Modeling of sulfur oxidation from elemental sulfur. Plant and Soil 155/156: 379-382.\n13. Hasanudin, H. 2003. Increasing of the nutrient and uptake availability of N and P andthrough corn yield of inoculation of Mycorrhiza and Azotobacter on ultisol organic matter. Journal of Agriculture Sciences of Indonesia 5 (1): 83-89.\n14. Izquierdo, N. G., and Aguirrezabal, L. A. N. 2008. Genetic variability in the response of fatty acid composition to minimum night temperature during grain filling in sunflower. Field Crops Research 106: 116-125.\n15. Jahan, M., Nassiri Mahallati, M., Amiri, M. B., and Ehyayi, H. R. 2013. Radiation absorption and use efficiency of sesame as affected by biofertilizers inoculation in a low input cropping system. Industrial Crops and Products 43: 606- 61.\n16. Kacar, B., and Katkat, A.V. 2007. Plant Nutrition. 3th Edn. Nobel Press; Ankara, Turkey.\n17. Kaplan, M., and Orman, S. 1998. Effect of elemental sulfur and sulfur containing waste in a calcareous soil in turkey. Plant Nutrient 21 (8): 1655-1665.\n18. Kennedy, I. R., Choudhury, A. T. M. A., and Kecske´s, M. L. 2004. Non-symbiotic bacterial diazotrophs in crop-farming systems:can their potential for plant growth promotion be better exploited? Soil Biology and Biochemistry 36: 1229-1244.\n19. Khan, K., Pankaj, U., Verma, S. K., Gupta, A. K., Singh, R. P., and Verma, R. K. 2015. Bio-inoculants and vermicompost influence on yield, quality of Andrographis paniculata, and soil properties. Industrial Crops and Products 70: 404-409.\n20. Kumar, S., Pandey, P., and Maheshwari, D. K. 2009. Reduction in dose of chemical fertilizers and growth enhancement of sesame (Sesamum indicum L.) with application of rhizospheric competent Pseudomonas aeruginosa LES4. European Journal of Soil Biology 45: 334-340.\n21. Kumar, A., Maury, B. R., and Raghuwanshi, R. 2014. . Isolation and characterization of PGPR and their effect on growth, yield and nutrient content in wheat (Triricum aestivum L.). Biocatalysis and Agricultural Biotechnology 3: 121-128.\n22. Marschner, H. 1995. Mineral Nutriton of higher plants. 2nd. ed. Academic Pres; San Diago, USA.\n23. Matthew, C. J., Bjorkman, M. K., David, M. K., Saito, A. M., and Zehr, P. J. 2008. Regional distributions of nitrogen-fixing bacteria in the Pacific Ocean. Limnol. Oceanogr 53: 63-77.\n24. Modaihsh, S., Al-mustafa, W. A., and Metwally, A. E. 1989. Effect of elemental sulfur on chemical changes and nutrient availability in calcareous soils. Plant and Soil 116: 95-101.\n25. Mohammadi, K. H., Ghalavand, A., Aghaalikhani, M., and Rokhzadi, A. 2011. Effect of different methods of increase soil fertility by adding organic, chemicals and biological fertilizers on grain yield and quality of canola (Brassica napus L.). Journal of Agroecology 3 (3): 298-308. (in Persian with English abstract).\n26. Mohanty, S., Paikaray, N. K., and Rajan, A. R. 2006. Availability and uptake of phosphorus from organic manures in groundnut (Arachis hypogea L.)-corn (Zea mays L.) sequence using radio tracer technique. Geoderma 133: 225-230.\n27. Page, A. L., Somner, C. E., and Nelson, P. W. 1996. Methods of soil analysis. Part 3. Chemical Methods. ASA/SSSA Madison, Wisconsin, USA\n28. Patrici, I. 2000. Integrated nutrient management for sustaining crop yield in calcareous soils of India. GAU-PRII-International Potash Institute. National Symposium. Junagadh. Gujarat. India.\n29. Phonglosa, A., Bhattacharyya, K., Ray, K., Mandal, J., Pari, A., Banerjee, H., and Chattopadhyay, A. 2015. Integrated nutrient management for okra in an inceptisol of easternIndia and yield modeling through artificial neural network. Scientia Horticulturae 187: 1-9.\n30. Rodrigues, E. P., Santos Rodrigues, L., Martinez de Oliveira, A. L., Baldani, V. L. D., Teixeira, K., Urquiaga, S., and Reis, V. M. 2008. Azospirillum amazonense inoculation: Effects on growth, yield and N2 fixation of rice (Oryza sativa L.). Plant and Soil 302: 249-261.\n31. Roesty, D., Gaur, R., and Johri, B. N. 2006. Plant growth stage, fertilizer management and bio-inoculation of arbuscular mycorrhizal fungi and plant growth promoting rhizobacteria affect the rhizobacterial. Community structure in rain-fed wheat fields. Journal of Plant Science 38: 1111-1120.\n32. Salimpour, S., Khavazi, K., Nadian, H., Besharati, H., and Miransari, M. 2010. Enhancing phosphorous availability to canola (Brassica napus L.) using P solubilizing and sulfur oxidizing bacteria. Australian Journal of Crop Science 4 (5): 330-334.\n33. Shakeri, E., Amini Dehaghi, M., Tabatabaei, S. A., and Modares Sanavi, S. M. A. 2012. Effect of chemical fertilizer and biofertilizer on seed yield, its components, oil and protein percent in sesame varieties. Journal ofagriculturalscienceandsustainable production 22 (1): 71-86. (in Persian with English abstract).\n34. Sharma, P. B. 2005. Fertilizer management in sesame (Sesamum indicum L.) based intercropping system in Tawa command area. Journal of Oilseeds Researsh 22: 63-65.\n35. Shata, S. M., Mahmoud, A., and Siam, S. 2007. Improving calcareous soil productivity by integrated effect of intercropping and fertilizer. Reacerch Journal of Agriculture and Biological Sciences 3(6): 733-739.\n36. Siami, A., and Besharaty, H. 2012. Effect of sulfur biological oxidation trend on release of iron and zinc. Iranian Journal of Soil Research 26 (3): 255- 267. (in Persian with English abstract).\n37. Uzun, B., Arslan, C., and Furat, S. 2008. Variation in fatty acid compositions, oil content and oil yield in a germplasm collection of Sesame (Sesamum indicum L.). Journal of the American Oil Chemists' Society 85: 1135-1142.\n38. Varzi, M. R., Habibi, D., Vazan, S., and Pakzi, A. 2011. The effect of plant growth promoting rhizobacteria and nitrogen fertilizer on grain quality of sunflower. Journal of Crop Ecophysiology 7: 156-160. (in Persian with English abstract).\n39. Vessy, K. 2003. Plant growth promoting rhizobacteria as biofertilizars. Plant and Soil 255: 571-586.\n40. Weiss, E. A. 2000. Oilseed Crops, 2nd ed., Blackwell Science Ltd., Bodmin, UK.\n41. Zapata, F., and Roy, R. N. 2004. Use of phosphate rocks for sustainable agriculture. p. 117-122. Publication of the FAO Land and Water Development Division.", "domain": "chemistry", "round": 3} +{"url": "http://sadipen.com/index.php/read/advances-in-bioceramics-and-biocomposites-ii-ceramic-engineering-and-science", "date": "2021-01-21T17:02:52Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-04/segments/1610703527224.75/warc/CC-MAIN-20210121163356-20210121193356-00466.warc.gz", "language_score": 0.778028666973114, "token_count": 1787, "dump": "CC-MAIN-2021-04", "global_id": "webtext-fineweb__CC-MAIN-2021-04__0__199444330", "lang": "en", "text": "By Mineo Mizuno, Andrew Wereszczak, Edgar Lara-Curzio\nUsing ceramics in organic environments and biomedical purposes is of accelerating value, as is the certainty of ways biology works with minerals to improve robust fabrics. those court cases include papers that debate the interface among biology and fabrics, offered on the court cases of the thirtieth foreign convention on complex Ceramics and Composites, January 22-27, 2006, Cocoa seashore, Florida. equipped and backed via the yank Ceramic Society and the yankee Ceramic Society's Engineering Ceramics department along with the Nuclear and Environmental expertise Division.Content:\nChapter 1 preliminary in Vitro interplay of Human Osteoblasts with Nanostructured Hydroxyapatite (NHA) (pages 3–14): Xuvgyuan Guo, Julie Gough, Ping Xiao, Jtng Ltu and Zhijian Shen\nChapter 2 Osteoblast reaction to Zinc?Doped Sintered P?Tricalcium Phosphate (pages 15–27): Sahil Jalota, Sarit B. Bhaduri and A. Cuneyt Tas\nChapter three selection of the Spatial solution of Micro?Focus X?Ray Ct approach with a customary Specimen (pages 29–36): Mineo Mizuno, Yasutoshi Mizuta, Takeharu Kato and Yasushi Ikeda\nChapter four Hydroxyapatite Hybridized with steel Oxides for Biomedical purposes (pages 39–47): Akiyoshi Osaka, Eiji Fujii, Koji Kawabata, Hideyuki Yoshimatsu, Satoshi Hayakawa, Kanji Tsuru, Christian Bonhomme and Florence Babonneau\nChapter five training of Self?Setting Cement?Based Micro? and Macroporous Granules of Carbonated Apatitic Calcium Phosphate (pages 49–60): A. Cuneyt Tas\nChapter 6 A Self?Setting, Monetite (CaHPO4) Cement for Skeletal fix (pages 61–69): Tarang R. Desai, Sarit B. Bhaduri and A. Cuneyt Tas\nChapter 7 Chemically Bonded Ceramics in line with Ca?Aluminates as Biomaterials (pages 71–86): L. Hermansson and H. Engqvist\nChapter eight A Theoritical and Mathematical foundation in the direction of Dispersing Nanoparticles and organic brokers in a Non Polar Solvent for Fabricating Porous fabrics (pages 87–94): Navin J. Manjooran and Gary R. Pickrell\nChapter nine education of Hydroxyapatite and Calcium Phosphate Bioceramic fabrics from the Aqueous resolution at Room Temperature (pages 95–101): Jia?Hui Liao, Yu?Chen Chang and Tzer?Shin Sheu\nChapter 10 Hydroxyapatite Coatings Produced by means of Plasma Spraying of natural dependent answer Precursor (pages 103–110): E. Garcia, Z. B. Zhang, T. W. Coyle, L. Gan and R. Pilliar\nChapter eleven Visible?Light Photocatalytic Fibers for Inactivation of Pseuwmonas Aeruginosa (pages 111–119): P. G. Wu, R. C. Xie, J. Imlay and J. ok. Shang\nChapter 12 Precipitation Mechanisms of Hydroxyapatite Powder within the assorted Aqueous options (pages 121–130): Yu?Chen Chang and Tzer?Shin Sheu\nChapter thirteen Conversion of Bioactive Silicate (45S5), Borate, and Borosilicate Glasses to Hydroxyapatite in Dilute Phosphate answer (pages 131–140): Wenhai Huang, Mohamed N. Rahaman and Delbert E. Day\nChapter 14 Variable Frequency Microwave (VFM) Processing: a brand new software to Crystallize Lithium Disilicate Glass (pages 143–153): Morsi Mahmoud, Diane Folz, Carlos Suchicital, David Clark and Zak Fathi\nRead Online or Download Advances in Bioceramics and Biocomposites II, Ceramic Engineering and Science Proceedings, Volume 27, Issue 6 PDF\nBest materials & material science books\nThe research of multi-component complicated structures composed of oxides, nitrides, and carbides has intensified within the previous couple of years. section Diagrams in complicated Ceramics experiences a number of the fresh advances inthe knowing of those composite structures, offering perception into how part diagrams can be used within the fabrication of whiskers and ceramic-matrix whisker-reinforced ceramics.\nThis beneficial source can assist the main precious features of nanostructured fabrics and nanotechnology. Containing sixteen peer-reviewed papers, this factor covers a number of points and the newest advancements regarding processing, modeling and production applied sciences of nanoscaled fabrics together with CNT and clay-based composites, nanowire-based sensors, new iteration photovoltaic cells, plasma processing of sensible skinny movies, ceramic membranes and self-assembled practical nanostructures.\nCreation to Computational Earthquake Engineering covers reliable continuum mechanics, finite aspect process and stochastic modeling comprehensively, with the second one and 3rd chapters explaining the numerical simulation of robust floor movement and faulting, respectively. Stochastic modeling is used for doubtful underground buildings, and complex analytical equipment for linear and non-linear stochastic types are provided.\n- Biosynthesis and Biodegradation of Wood Components\n- Classic and Advanced Ceramics\n- Foundations of Solid Mechanics\nAdditional info for Advances in Bioceramics and Biocomposites II, Ceramic Engineering and Science Proceedings, Volume 27, Issue 6\nJ. Fraker, “Roles for cell death in zinc deficiency,” J. , 135,359-62 (2005). P. ,” Endeavour, 8,65-70 (1984). A. Fuierer, M. A. H. Nancollas, “A mineralization adsorption and mobility study of hydroxyapatite surfaces in the presence of zinc and magnesium ions,” Lungmuir, 10,4721-5 (1994). Z. LeGeros, Curies Res. 31,434 (1997). Z. B. Bleiwas, M. Retino, R. P. LeGeros, “Zinc effect on the in vitro formation of calcium phosphates: Relevance to clinical inhibition of calculus formation,” Am. J. , 12,6571 (1999).\nMiyakawa, P. Layrolle, K. Ojima, N. Ichinose, and T. Tateishi, “Stimulatory effect of zinc-releasing calcium phosphate implant on bone formation in rabbit femora,” J. Biomed. Muter. , 50, 184-90 (2000). 14 Advances in Bioceramicsand Biocomposites II . 25 33 M. Otsuka, S. Marunaka, Y. Matsuda, A. Ito, P. Layrolle, H. Naito, and N. Ichinose, “Calcium level-responsive in-vitro zinc release from zinc containing tricalcium phosphate (ZnTCP),” J. Biomed. Muter. , 52,819-24 (2000). 34 N. Kanzaki, K. Onuma, G.\nMarunaka, Y. Matsuda, A. Ito, P. Layrolle, H. Naito, and N. Ichinose, “Calcium level-responsive in-vitro zinc release from zinc containing tricalcium phosphate (ZnTCP),” J. Biomed. Muter. , 52,819-24 (2000). 34 N. Kanzaki, K. Onuma, G. Treboux, S. Tsutsumi, and A. Ito, “Effect of impurity on two-dimensional nucleation kinetics: Case studies of magnesium and zinc on hydroxyapatite (0001) face,”J. Phys. Chem. , 105, 1991-4 (2001). A. Ito, H. Kawamura, M. Otsuka, M. Ikeuchi, H. Ohgushi, K. Ishikawa, K.", "domain": "chemistry", "round": 3} +{"url": "http://www.mdpi.com/1420-3049/21/1/23", "date": "2018-02-23T03:19:27Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-09/segments/1518891814311.76/warc/CC-MAIN-20180223015726-20180223035726-00074.warc.gz", "language_score": 0.8334135413169861, "token_count": 486, "dump": "CC-MAIN-2018-09", "global_id": "webtext-fineweb__CC-MAIN-2018-09__0__144672941", "lang": "en", "text": "Benz[c,d]indolium-containing Monomethine Cyanine Dyes: Synthesis and Photophysical Properties\nAbstractAsymmetric monomethine cyanines have been extensively used as probes for nucleic acids among other biological systems. Herein we report the synthesis of seven monomethine cyanine dyes that have been successfully prepared with various heterocyclic moieties such as quinoline, benzoxazole, benzothiazole, dimethyl indole, and benz[e]indole adjoining benz[c,d]indol-1-ium, which was found to directly influence their optical and energy profiles. In this study the optical properties vs. structural changes were investigated using nuclear magnetic resonance and computational approaches. The twisted conformation unique to monomethine cyanines was exploited in DNA binding studies where the newly designed sensor displayed an increase in fluorescence when bound in the DNA grooves compared to the unbound form. View Full-Text\n- Supplementary File 1:\nSupplementary (PDF, 1690 KB)\nScifeed alert for new publicationsNever miss any articles matching your research from any publisher\n- Get alerts for new papers matching your research\n- Find out the new papers from selected authors\n- Updated daily for 49'000+ journals and 6000+ publishers\n- Define your Scifeed now\nSoriano, E.; Holder, C.; Levitz, A.; Henary, M. Benz[c,d]indolium-containing Monomethine Cyanine Dyes: Synthesis and Photophysical Properties. Molecules 2016, 21, 23.\nSoriano E, Holder C, Levitz A, Henary M. Benz[c,d]indolium-containing Monomethine Cyanine Dyes: Synthesis and Photophysical Properties. Molecules. 2016; 21(1):23.Chicago/Turabian Style\nSoriano, Eduardo; Holder, Cory; Levitz, Andrew; Henary, Maged. 2016. \"Benz[c,d]indolium-containing Monomethine Cyanine Dyes: Synthesis and Photophysical Properties.\" Molecules 21, no. 1: 23.\nNote that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.", "domain": "chemistry", "round": 3} +{"url": "http://psychology.wikia.com/wiki/Opioid_neuropeptide", "date": "2017-08-18T10:57:16Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-34/segments/1502886104634.14/warc/CC-MAIN-20170818102246-20170818122246-00003.warc.gz", "language_score": 0.856654167175293, "token_count": 482, "dump": "CC-MAIN-2017-34", "global_id": "webtext-fineweb__CC-MAIN-2017-34__0__9950208", "lang": "en", "text": "Individual differences |\nMethods | Statistics | Clinical | Educational | Industrial | Professional items | World psychology |\nBiological: Behavioural genetics · Evolutionary psychology · Neuroanatomy · Neurochemistry · Neuroendocrinology · Neuroscience · Psychoneuroimmunology · Physiological Psychology · Psychopharmacology (Index, Outline)\nOpioid Peptides are short sequences of amino acids which mimic the effect of opiates in the brain. Opioid peptides may be produced by the body itself, for example endorphins, or be absorbed from partially digested food (casomorphins, exorphins and rubiscolins). The effect of these peptides vary, but they all resemble opiates. The opioid food peptides have lengths of typically 4-8 amino acids. The body's own opioids are generally much longer.\nOpioid peptides produced by the body Edit\nThe human genome contains three homologous genes that are known to code for endogenous opioid peptides. Each gene codes for a large protein that can be processed to yield smaller peptides that have opiate-like activity.\n- The nucleotide sequence of the human gene for proopiomelanocortin (POMC) was characterized in 1980. The POMC gene codes for endogenous opiates such as β-endorphin and gamma-endorphin. The peptides with opiate activity that are derived from proopiomelanocortin comprise the class of endogenous opioid peptides called \"endorphins\".\n- The human gene for enkephalins was isolated and its sequence described in 1982.\n- The human gene for dynorphins (originally called the \"Enkephalin B\" gene because of sequence similarity to the enkephalin gene) was isolated and its sequence described in 1983.\n- Opiorphin, found in human saliva, is an enkephalinase inhibitor, i.e. it prevents the metabolism of enkephalins.\n- Casomorphin (from milk)\n- Gluten exorphin (from gluten)\n- Gliadorphin/gluteomorphin (from gluten)\n- Rubiscolin (from spinach)\nReferences & BibliographyEdit\ntags exist, but no\ntag was found", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/ppp2r4-antibody-ab227243.html", "date": "2020-10-21T08:08:04Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-45/segments/1603107876136.24/warc/CC-MAIN-20201021064154-20201021094154-00089.warc.gz", "language_score": 0.7720484733581543, "token_count": 817, "dump": "CC-MAIN-2020-45", "global_id": "webtext-fineweb__CC-MAIN-2020-45__0__90365745", "lang": "en", "text": "Key features and details\n- Rabbit polyclonal to PPP2R4\n- Suitable for: ICC/IF, WB\n- Reacts with: Human\n- Isotype: IgG\nProduct nameAnti-PPP2R4 antibody\nSee all PPP2R4 primary antibodies\nDescriptionRabbit polyclonal to PPP2R4\nTested applicationsSuitable for: ICC/IF, WBmore details\nSpecies reactivityReacts with: Human\nPredicted to work with: Mouse, Rat, Rabbit\nRecombinant fragment within Human PPP2R4 (internal sequence). The exact sequence is proprietary.\nDatabase link: Q15257\n- ICC/IF: HeLa cells. WB: A549 whole cell lysate.\nStorage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.\nStorage bufferpH: 7.00\nPreservative: 0.01% Thimerosal (merthiolate)\nConstituents: 1.21% Tris, 0.75% Glycine, 20% Glycerol\nConcentration information loading...\nPurityImmunogen affinity purified\nOur Abpromise guarantee covers the use of ab227243 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\n|ICC/IF||1/100 - 1/1000.|\n|WB||1/500 - 1/3000. Predicted molecular weight: 41 kDa.|\nFunctionPPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for serine/threonine-protein phosphatase 2A (PP2A) modulating its activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a proposed direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2A(i)) in presence of ATP and Mg(2+) (By similarity). Reversibly stimulates the variable phosphotyrosyl phosphatase activity of PP2A core heterodimer PP2A(D) in presence of ATP and Mg(2+) (in vitro). The phosphotyrosyl phosphatase activity is dependent of an ATPase activty of the PP2A(D):PPP2R4 complex. Is involved in apoptosis; the function appears to be independent from PP2A.\nTissue specificityWidely expressed.\nSequence similaritiesBelongs to the PTPA-type PPIase family.\nCellular localizationCytoplasm. Nucleus.\n- Information by UniProt\n- subunit B'' antibody\n- KIAA0044 antibody\n- MGC2184 antibody\nParaformaldehyde-fixed HeLa (human epithelial cell line from cervix adenocarcinoma) cells stained for PPP2R4 (green) using ab227243 at 1/500 dilution in ICC/IF.\nAlpha-tubulin filaments were labeled red.\nAnti-PPP2R4 antibody (ab227243) at 1/1000 dilution + A549 (human lung carcinoma cell line) whole cell lysate at 30 µg\nPredicted band size: 41 kDa\n10% SDS-PAGE gel.\nTo our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.\nab227243 has not yet been referenced specifically in any publications.", "domain": "chemistry", "round": 3} +{"url": "https://www.iag.co.at/en/product/dew-point-and-temperature-probe-dmp5", "date": "2023-12-11T12:33:09Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679511159.96/warc/CC-MAIN-20231211112008-20231211142008-00440.warc.gz", "language_score": 0.8318560123443604, "token_count": 384, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__133327332", "lang": "en", "text": "Dewpoint and Temperature probe DMP5 for in-line measurement in high temperature applications <180 °C\nVaisala DRYCAP® Dew Point and Temperature Probe DMP5 is designed for in-line humidity measurement in industrial drying applications with high temperatures and a wide dew point range. The long and robust steel probe and optional installation flange allow easy installation with adjustable depth to reach through insulation, for example in ovens.\nDMP5 incorporates the Vaisala DRYCAP® sensor, which is accurate, reliable, and stable. The sensor is condensation-resistant and immune to particulate contamination, oil vapor, and most chemicals. Sensor warming minimizes the risk of condensation accumulating on the sensor. If the DRYCAP® sensor does get wet, it dries rapidly and recovers its swift response time. In low-humidity conditions the sensor will auto-calibrate to ensure accurate measurement.\nDMP5 is part of the Indigo family and is compatible with the Indigo500 and Indigo200 series transmitters. It can be used with Vaisala Insight PC software for data visualization, easy probe configuration, and self-calibration.\n- Measures humidity at temperatures up to 180 °C (356 °F)\n- Wide dew point measurement range -40 ... +100 °C (-40 ... +212 °F) Td\n- Dew point measurement accuracy up to ± 2 °C ( ± 3.6 °F)\n- Temperature accuracy up to 0.1 °C (0.18 °F)\n- Sensor purge provides superior chemical resistance\n- Withstands condensation, oils, dust and most chemicals\n- Modbus RTU over RS-485 for flexible connectivity\n- Compatible with Indigo series transmitters\n- Includes traceable three-point calibration certificate\n- Long (two year) calibration interval for easy maintenance", "domain": "chemistry", "round": 3} +{"url": "https://benthamscience.com/journals/nanoscience-and-nanotechnology-asia/animated-abstract/", "date": "2020-03-30T17:31:43Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-16/segments/1585370497171.9/warc/CC-MAIN-20200330150913-20200330180913-00254.warc.gz", "language_score": 0.9269233345985413, "token_count": 373, "dump": "CC-MAIN-2020-16", "global_id": "webtext-fineweb__CC-MAIN-2020-16__0__3801846", "lang": "en", "text": "We recommend authors to publish their Animated Abstract, along with the article abstract, to extend the coverage of the published articles.\nBentham Science has collaborated with Focus Medica, one of the world's largest publishers of expert animated atlases and videos in medicine and science, to create an Animated Abstract of the article. Animated Abstracts will be published as open access (free-to-view) and help summarize the essential discoveries/key findings of the research, highlight the importance of the article for further research and utilization in the relevant industry. Each professionally produced, full-colored animated abstract, in video format (length 3 – 5 minutes) is accompanied by an English or foreign language commentary.\nAuthors can avail this service against a fee to get the Animated Abstract published with the textual / graphical abstract on the Journal's homepage (for reference, please visit: http://www.eurekaselect.com/video.html).\nIt will serve to define and gain attention for the article. For more information, please view the ‘Author Guidelines’.\nBai Yang received his PhD in Polymer Chemistry and Physics from Jilin University, China and is working on the design and synthesis of high performance optical polymer and then going on the preparation of polymer nanocomposite and hybrids with high refractive index and photo-electric functionalities. He received the Outstanding Youth Fund from NSFC and the honors of Chenug Kong Scholar from the Ministry of Education of China. He has published 430 SCI papers with sum citation of more than10600 times. His current research interests are focused on polymeric nano-hybridization and photo-electronic materials and devices via aqueous approaches, high performance polymeric hybrid optical materials and ordered fabrication of polymeric microstructures with multi-scale and photonic responsive materials.", "domain": "chemistry", "round": 3} +{"url": "https://advbiomart.net/rat_monoclonal_antibody_production.html", "date": "2023-12-04T20:22:26Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100534.18/warc/CC-MAIN-20231204182901-20231204212901-00335.warc.gz", "language_score": 0.8700598478317261, "token_count": 271, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__101393422", "lang": "en", "text": "Rat Monoclonal Antibody Production\nhas developed a unique platform to develop high-affinity rat monoclonal antibodies.Compared with mouse antibodies, rat monoclonal antibodies offer several advantages over mouse antibodies.Rat monoclonal antibodies may have better specificity and affinity in certain applications. The rat immune system exhibits stronger reactivity to antigens, allowing for the generation of antibodies with higher affinity and greater specificity.Rat monoclonal antibodies typically have a longer serum half-life. This means that they circulate in the body for a longer period of time, potentially providing more sustained effects in therapeutic or diagnostic applications. Rat monoclonal antibodies may be more suitable for certain specific research areas and applications. For example, when studying rat models, the use of rat monoclonal antibodies can avoid cross-reactivity or specificity issues caused by species differences.\nWe have optimized the entire rat monoclonal antibody development process to increase efficiency and probability of success. We guarantee the positive clones for monoclonal antibodies developed in rats.\nRat Monoclonal Antibody Production: One-Stop Services\nFor quotation requests and other detailed information, Welcome to contact us or send an email to [email protected].\nHigh affinity and specificity\nUsed for murine antigens\nNo special growth media required", "domain": "chemistry", "round": 3} +{"url": "https://hg.gatech.edu/node/641097", "date": "2023-03-21T15:37:31Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-14/segments/1679296943698.79/warc/CC-MAIN-20230321131205-20230321161205-00304.warc.gz", "language_score": 0.9080639481544495, "token_count": 828, "dump": "CC-MAIN-2023-14", "global_id": "webtext-fineweb__CC-MAIN-2023-14__0__217460360", "lang": "en", "text": "PhD Defense by Chunyan Xu\nPh.D. Thesis Defense Announcement Development and Mechanism Investigation of Novel Thin Film Nanocomposite Nanofiltration Membranes by Chunyan Xu Advisor(s): Dr. Yongsheng Chen Committee Members: Dr. John Crittenden (CEE), Dr. Sotira Yiacoumi (CEE), Dr. Xing Xie (CEE), Dr. Shuman Xia (ME) Date & Time: Friday, Nov. 20th, 9:00-11:00 am Location: https://bluejeans.com/429539129 Thin film composite (TFC) membrane based nanofiltration (NF) is an emerging technology that has shown great potential in water purification, waste treatment, and organic solvent separations. Great performance has already been achieved through a variety of modifications for different applications; however, a lack of understanding of the underlying water transport mechanism and multifunctional potential of TFC membranes present significant challenges. One clear example are thin film nanocomposite (TFN) membranes, which have shown enhanced water flux as well as other capabilities, such as antifouling, antibacterial, and anti-compaction properties. However, the underlying mechanism for these excellent properties exhibited by the TFN membranes remains largely unknown. In addition, these properties are mainly improved individually in previous studies, but in practical application, optimal multi-functional TFN membranes that exhibit all these great properties simultaneously are preferred. Motivated by the abovementioned questions and the need for real applications, the overall objective of this thesis is to use both experimental phenomenal observations and mechanistic modeling investigations to understand the mass transport mechanism and enhance the overall performance of TFN membranes. Firstly, I developed a novel multifunctional NF membrane by incorporating cellulose nanocrystal/ silver (CNC/Ag) nanocomposites into the active layer of the thin film composite NF membrane. The CNC/Ag NF membrane exhibited excellent anti-fouling and antibacterial properties, in addition to an enhancement in water permeability without sacrificing salt rejection. Secondly, based upon the results observed from our TFN membranes experiments and other works done in recent years, I developed a novel water and solute transport model to explain the widely observed flux enhancement and solute rejection changes of TFN membranes using resistance-in-series theory and Monte Carlo simulation. The simulation results explain why a minimal NPs addition (typically less than 0.1 wt% in the monomer solution for interfacial polymerization) would result in a significant flux increase without sacrificing rejection. Also, the range of the flux enhancement (1.1 to 2.5 times) and minor rejection change simulated by our model agree very well with the existing experimental data from a variety of previous publications. Finally, the TFC membrane real-time compaction model was developed based on scaling-law calculations combined with the viscoelastic behavior of the polymer. The effect of different morphological and mechanical properties, as well as the transmembrane pressure are thoroughly discussed, which will not only give insight on the anti-compaction behavior of TFC membranes, but also contribute to future study of the TFN membrane compaction mechanism. In summary, this thesis has successfully demonstrated the preparation of a multifunctional TFN membrane with high performance under different assessment criteria, and the development of two mathematical models: a model that captures and explains the mass transport of TFN membranes, and a model that can be used to explain and predict TFN membrane compaction using viscoelastic theory. These works paved the way to future studies of novel TFN membranes, as well as developed a novel set of math modeling techniques that can explain and predict the performance of TFN membranes.\n- Workflow Status: Published\n- Created By: Tatianna Richardson\n- Created: 11/06/2020\n- Modified By: Tatianna Richardson\n- Modified: 11/06/2020", "domain": "chemistry", "round": 3} +{"url": "http://energyelec.com/index.php/pdf/protein-lipidation-21-the-enzymes", "date": "2019-07-16T00:45:22Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-30/segments/1563195524290.60/warc/CC-MAIN-20190715235156-20190716021156-00551.warc.gz", "language_score": 0.8903778791427612, "token_count": 399, "dump": "CC-MAIN-2019-30", "global_id": "webtext-fineweb__CC-MAIN-2019-30__0__210577197", "lang": "en", "text": "By Fuyuhiko Tamanoi,David S. Sigman\n- The enzymatic mechanisms of protein lipidation\n- Three-dimensional constructions of protein farnesytransferase, protein geranylgeranytransferase II, and n-myristoryltransferase\nRead Online or Download Protein Lipidation: 21 (The Enzymes) PDF\nSimilar molecular biology books\nMicroarray expertise has made robust development over the last decade, and there have additionally been major alterations in program parts, from nucleic acids to proteomics and from examine to scientific functions. This ebook presents a entire evaluate of microarrays in diagnostics and biomarker improvement, protecting DNA, peptide, protein and tissue arrays.\nThis booklet will offer most modern insights in the practical potentials of ribonucleic acids in medine and the use of Spiegelmer and Spiegelzyme platforms. it's going to additionally deal with a new form of supply structures for mobile targeting.\nFiguring out how digestive organs enhance, their body structure and constitution is critical for choosing new cures to strive against ailments of the digestive organs. This quantity reports the most recent learn and advancements during this box. * Discusses new discoveries, techniques, and concepts * Contributions from prime students and specialists * Reference advisor for researchers concerned about molecular biology and similar fields\nThroughout the process the immune reaction, antigen-activated B cells produce antibodies with elevated affinity for the antigen, a method referred to as affinity maturation. a number produces antibodies with successively higher affinities with repeated publicity to a similar antigen, that is the primary during which so much vaccines paintings.\n- Biochemistry and Molecular Biology Compendium\n- A History of Immunology\n- Hematopathology: Genomic Mechanisms of Neoplastic Diseases (Molecular and Translational Medicine)\n- Cholesterol Regulation of Ion Channels and Receptors\nExtra resources for Protein Lipidation: 21 (The Enzymes)", "domain": "chemistry", "round": 3} +{"url": "http://wirdahl.com/an-immunodominant-proteins-from-strains-isolated-from-mycetoma-the-fact-that/", "date": "2022-08-08T20:25:11Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882570871.10/warc/CC-MAIN-20220808183040-20220808213040-00323.warc.gz", "language_score": 0.9268558621406555, "token_count": 945, "dump": "CC-MAIN-2022-33", "global_id": "webtext-fineweb__CC-MAIN-2022-33__0__66940619", "lang": "en", "text": "An immunodominant proteins from strains isolated from mycetoma. the fact that cellular immune system response is vital in level of resistance (8, 12, 20, 32). Conversely, the function MLLT7 of antibodies isn’t more developed, and their creation can also be considered a negative aspect for the web host during infections (20). Many immunological assays have already been conducted through the use of complicated mixtures of nocardial antigens. To be able to determine the immunodominant antigens of acknowledged by the sufferers disease fighting capability, we examined by Traditional western blot a crude remove from using a -panel of sera from sufferers with mycetoma (23). Within this research we also examined the cross-reactivity with various other actinomycetes by tests LBH589 (Panobinostat) IC50 sera from sufferers with tuberculosis and leprosy. In these assays, we noticed that mycetoma sufferers created antibodies that even more LBH589 (Panobinostat) IC50 known three proteins of 61 often, 26, and 24 kDa which were specified as P61, P26, and P24, respectively. The sera from sufferers with mycetoma determined various other proteins in the molecular mass selection of 35 to 45 kDa, but sera from individuals with tuberculosis and leprosy identified these rings also. We’ve isolated the P61 and P24 protein (26), as well as the last mentioned (P24) continues to be found to become useful in the recognition of antinocardial antibodies (24). To be able to determine the identification of these protein, it’s important to determine their N-terminal amino-acid sequences also to clone the genes. Within this ongoing function we subjected one of these, P61, to amino acidity series evaluation and could actually obtain a incomplete nucleotide series of the gene. In comparison towards the GenBank data source aswell as by learning its enzymatic activity on H2O2, we conclude that it’s an catalase. We also motivated the current presence of this series or equivalent sequences in various other actinomycetes. Because of this and pursuing studies, we’ve specified the gene coding for the catalase as (for nocardial catalase). Strategies and Components Purification from the HUJEG-1 P61. The technique utilized to purify P61 continues to be released previously (26). Quickly, a batch lifestyle (7 to 10 liters) of HUJEG-1 was ready in brain center infusion (Difco) and incubated for seven days at 37C. The cells had been harvested, cleaned with distilled drinking water, and defatted with ethanol-ethyl ether. A crude mobile remove was attained by sonication from the bacterial mass within a Biosonik equipment (Bronwill Scientific, Rochester, N.Con.) at a 60-probe strength for LBH589 (Panobinostat) IC50 30 min within an glaciers bath. The suspension system was centrifuged at 3,000 for 15 min to eliminate fragments and unbroken cells, as well as the soluble small fraction was attained by centrifugation at 144,000 for 3 h at 4C within an L8-70M ultracentrifuge (Beckman, Palo Alto, Calif.). P61 was isolated by precipitation through the supernatant through the use of ammonium sulfate at a 50% saturation. Following the pellet was separated by centrifugation at 600 crude remove, aswell as 30 g of the crude remove of gene fragment. To be able to determine the current presence of consensus amino acidity sequences in catalases linked to P61, we aligned several catalase sequences of eukaryotic and prokaryotic source that included the next microorganisms: catalase. Predicated on this evaluation we designed a PCR assay with degenerate oligonucleotide primers LBH589 (Panobinostat) IC50 that used section of SeqnNB2 (FDLTQV) and VGNNTP (discover Table ?Desk4).4). The PCR assay was completed utilizing the three-step system inside a PTC-200 DNA Engine (MJ Study, Watertown, Mass.), but with an annealing temp of 50C to create a 500-bp item. For the series evaluation from the PCR item, a 200-l response was utilized, and the merchandise was gel purified with.", "domain": "chemistry", "round": 3} +{"url": "http://tw.sinobiological.com/Mouse-WTAP-Gene-cDNA-Clone-(full-length-ORF-Clone),-expression-ready,-C-FLAG-tagged_p102788.html", "date": "2017-04-24T20:51:08Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-17/segments/1492917119838.12/warc/CC-MAIN-20170423031159-00256-ip-10-145-167-34.ec2.internal.warc.gz", "language_score": 0.6705337762832642, "token_count": 1311, "dump": "CC-MAIN-2017-17", "global_id": "webtext-fineweb__CC-MAIN-2017-17__0__63025498", "lang": "en", "text": "|Vector Type||Mammalian Expression Vector|\n|Expression Method||Constiutive, Stable / Transient|\n|Selection In Mammalian Cells||Hygromycin|\nFLAG-tag, or FLAG octapeptide, is a polypeptide protein tag that can be added to a protein using recombinant DNA technology. It can be used for affinity chromatography, then used to separate recombinant, overexpressed protein from wild-type protein expressed by the host organism. It can also be used in the isolation of protein complexes with multiple subunits.\nA FLAG-tag can be used in many different assays that require recognition by an antibody. If there is no antibody against the studied protein, adding a FLAG-tag to this protein allows one to follow the protein with an antibody against the FLAG sequence. Examples are cellular localization studies by immunofluorescence or detection by SDS PAGE protein electrophoresis.\nThe peptide sequence of the FLAG-tag from the N-terminus to the C-terminus is: DYKDDDDK (1012 Da). It can be used in conjunction with other affinity tags, for example a polyhistidine tag (His-tag), HA-tag or Myc-tag. It can be fused to the C-terminus or the N-terminus of a protein. Some commercially available antibodies (e.g., M1/4E11) recognize the epitope only when it is present at the N-terminus. However, other available antibodies (e.g., M2) are position-insensitive.\n|小鼠 WTAP 基因全長cDNA ORF克隆 (表達載體), C-GFPSpark 標籤||MG52198-ACG|\n|小鼠 WTAP 基因全長cDNA ORF克隆 (表達載體), C-OFPSpark 標籤||MG52198-ACR|\n|小鼠 WTAP 基因全長cDNA ORF克隆 (表達載體), N-GFPSpark 標籤||MG52198-ANG|\n|小鼠 WTAP 基因全長cDNA ORF克隆 (表達載體), N-OFPSpark 標籤||MG52198-ANR|\n|小鼠 WTAP 基因全長cDNA ORF克隆 (表達載體), C-Flag 標籤||MG52198-CF|\n|小鼠 WTAP 基因全長cDNA ORF克隆 (表達載體), C-His 標籤||MG52198-CH|\n|小鼠 WTAP 基因全長cDNA ORF克隆 (表達載體), C-Myc 標籤||MG52198-CM|\n|小鼠 WTAP 基因全長cDNA ORF克隆 (表達載體), C-HA 標籤||MG52198-CY|\n|小鼠 WTAP 基因全長cDNA ORF(克隆載體)||MG52198-G|\n|小鼠 WTAP 基因全長cDNA ORF克隆 (表達載體), N-Flag 標籤||MG52198-NF|\n|小鼠 WTAP 基因全長cDNA ORF克隆 (表達載體), N-His 標籤||MG52198-NH|\n|小鼠 WTAP 基因全長cDNA ORF克隆 (表達載體), N-Myc 標籤||MG52198-NM|\n|小鼠 WTAP 基因全長cDNA ORF克隆 (表達載體), N-HA 標籤||MG52198-NY|\n|小鼠 WTAP 基因全長cDNA ORF克隆 (表達載體)||MG52198-UT|\nWilms' tumor 1-associating protein (WTAP) was previously identified as a protein associated with Wilms' tumor-1 (WT-1) protein that is essential for the development of the genitourinary system. WT1 was originally identified as a tumor suppressor for Wilms' tumor, but it is also overexpressed in a variety of cancer cells. The WTAP-WT1 axis in vascular cells suggest that WTAP is a vital and multifaceted regulator of vascular remodeling. WTAP has been suggested to function in alternative splicing, stabilization of mRNA, and cell growth. Knocking down endogenous WTAP increased Smooth muscle cells (SMCs) proliferation, because of increased DNA synthesis and G(1)/S phase transition, together with reduced apoptosis. These effects could be the result of WTAP suppressing the transcriptional activity of WT1 in SMCs. WTAP may thus also play a role in messenger RNA processing in mammalian cells, either dependent on or independent of its interaction with WT1.", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/leptin-antibody-biotin-ab84017.html", "date": "2020-09-26T17:05:35Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-40/segments/1600400244353.70/warc/CC-MAIN-20200926165308-20200926195308-00361.warc.gz", "language_score": 0.7747072577476501, "token_count": 606, "dump": "CC-MAIN-2020-40", "global_id": "webtext-fineweb__CC-MAIN-2020-40__0__225709763", "lang": "en", "text": "Key features and details\n- Goat polyclonal to Leptin (Biotin)\n- Suitable for: Sandwich ELISA, WB\n- Reacts with: Rat\n- Conjugation: Biotin\n- Isotype: IgG\nProduct nameAnti-Leptin antibody (Biotin)\nSee all Leptin primary antibodies\nDescriptionGoat polyclonal to Leptin (Biotin)\nTested applicationsSuitable for: Sandwich ELISA, WBmore details\nSpecies reactivityReacts with: Rat\nHighly pure (>98%) recombinant Rat Leptin\nFormLyophilized:Centrifuge vial prior to opening. Reconstitute in sterile PBS containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml.\nStorage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.\nStorage bufferpH: 7.20\nConcentration information loading...\nPurityImmunogen affinity purified\nPurification notesab84017 is sterile filtered.\nOur Abpromise guarantee covers the use of ab84017 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\n|Sandwich ELISA||Use a concentration of 0.25 - 1 µg/ml.\nAllows the detection of at least 0.2 - 0.4 ng/well of recombinant rat Leptin.\n|WB||Use a concentration of 0.1 - 0.2 µg/ml. Predicted molecular weight: 19 kDa.\nThe detection limit for recombinant Rat Leptin is 1.5 - 3.0 ng/lane, under either reducing or non-reducing conditions.\nFunctionMay function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass.\nInvolvement in diseaseDefects in LEP may be a cause of obesity (OBESITY) [MIM:601665]. It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.\nSequence similaritiesBelongs to the leptin family.\n- Information by UniProt\n- FLJ94114 antibody\n- LEP antibody\n- LEP_HUMAN antibody\nTo our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.\nab84017 has not yet been referenced specifically in any publications.", "domain": "chemistry", "round": 3} +{"url": "https://www.thenewzthing.com/what-are-the-major-differences-between-simple-carbs-and-complex-carbs/", "date": "2023-10-04T05:46:37Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233511361.38/warc/CC-MAIN-20231004052258-20231004082258-00840.warc.gz", "language_score": 0.9566330909729004, "token_count": 643, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__157066164", "lang": "en", "text": "Carbs come in two different forms – simple and complex.\nThese two types affect your blood sugar in two different ways. So, it’s highly important to understand the difference between them, to maintain a balanced diet.\nCarbs, or carbohydrates as they’re called, are one of your body’s main sources of energy. So, needless to say, that carbs make an essential part of a healthy, balanced diet. However, what most people are unaware of is that not all carbs are the same. As already mentioned, they come in two forms – simple and complex – and the two have lots of differences.\n(They have a few similarities as well. Both simple and complex carbs are composed of carbon, hydrogen, and oxygen atoms. Also, the hydrogen to oxygen ratio in both of them is 2:1.)\nFoods containing simple & complex carbs\nBoth these carbs are present in a variety of foods. Simple carbs are available in fruits, dairy, and certain vegetables – which are packed with lots of nutrients. But the list also includes cookies, sugary drinks, and other processed foods that can be harmful to your health. On the other hand, complex carbs are mostly present in foods like brown rice, wild rice, corn, barley, oatmeal, asparagus, quinoa, potatoes, sweet potatoes, lentils, chickpeas, kidney beans, etc. So, in terms of nutrition, complex carbs are a lot better option than simple carbs.\nThey have different chemical structures\nSimple carbs’ chemical structure is quite basic. They come in two main types – monosaccharides (which contain a single sugar molecule) and disaccharides (which are made up of two simple sugars linked together). On the other hand, complex carbs – as the name suggests – have a relatively complex chemical structure. They are known as polysaccharides, consisting of hundreds or sometimes thousands of monosaccharide units.\nThey have different speeds of digestion\nSimple carbs are easy to digest, and also get absorbed quickly in the body. So, they cause an instant spike in your blood sugar levels. The excess carbs that are not absorbed get converted into fats and then stored in your body’s cells. This eventually leads you to gain weight.\nOn the other hand, complex carbs take a longer time to digest in the body. So, it’s evident that they raise the blood sugar level very slowly.\nSo, which carbs should you eat?\nWell, it’s already clear that when it comes to a healthy diet, complex carbs are a lot better option than simple carbs. Now, let’s elaborate on it.\nConsumption of simple carbs in excess is linked to a range of health issues. Firstly, it can lead you to obesity – which is further associated with many conditions. Also, it increases your risk of developing diabetes, heart diseases, and more.\nThere’s evidence that complex carbs might be beneficial for human health. If eaten in moderation, they aid in digestion, relieve inflammation, and also reduce your risk of chronic diseases.", "domain": "chemistry", "round": 3} +{"url": "https://frontiersin.figshare.com/articles/dataset/Table_1_Depletion_of_ATP-Citrate_Lyase_ATPCL_Affects_Chromosome_Integrity_Without_Altering_Histone_Acetylation_in_Drosophila_Mitotic_Cells_XLSX/7949852/1", "date": "2021-12-02T16:19:24Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-49/segments/1637964362230.18/warc/CC-MAIN-20211202145130-20211202175130-00279.warc.gz", "language_score": 0.7883430123329163, "token_count": 790, "dump": "CC-MAIN-2021-49", "global_id": "webtext-fineweb__CC-MAIN-2021-49__0__162091084", "lang": "en", "text": "Table_1_Depletion of ATP-Citrate Lyase (ATPCL) Affects Chromosome Integrity Without Altering Histone Acetylation in Drosophila Mitotic Cells.XLSX\nThe Citrate Lyase (ACL) is the main cytosolic enzyme that converts the citrate exported from mitochondria by the SLC25A1 carrier in Acetyl Coenzyme A (acetyl-CoA) and oxaloacetate. Acetyl-CoA is a high-energy intermediate common to a large number of metabolic processes including protein acetylation reactions. This renders ACL a key regulator of histone acetylation levels and gene expression in diverse organisms including humans. We have found that depletion of ATPCL, the Drosophila ortholog of human ACL, reduced levels of Acetyl CoA but, unlike its human counterpart, does not affect global histone acetylation and gene expression. Nevertheless, reduced ATPCL levels caused evident, although moderate, mitotic chromosome breakage suggesting that this enzyme plays a partial role in chromosome stability. These defects did not increase upon X-ray irradiation, indicating that they are not dependent on an impairment of DNA repair. Interestingly, depletion of ATPCL drastically increased the frequency of chromosome breaks (CBs) associated to mutations in scheggia, which encodes the ortholog of the mitochondrial citrate carrier SLC25A1 that is also required for chromosome integrity and histone acetylation. Our results indicate that ATPCL has a dispensable role in histone acetylation and prevents massive chromosome fragmentation when citrate efflux is altered.", "domain": "chemistry", "round": 3} +{"url": "https://vestalubrication.com/product/evolution-5w-30-sn-gf-5/", "date": "2024-04-18T03:37:28Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712296817187.10/warc/CC-MAIN-20240418030928-20240418060928-00140.warc.gz", "language_score": 0.8340020179748535, "token_count": 1125, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__151613037", "lang": "en", "text": "EVOLUTION 5W/30 SN GF-5 stands as the ultimate engine lubricant, offering unparalleled engine protection and fuel efficiency for both new and older petrol and small diesel engines. It rigorously adheres to the API SN Plus and ILSAC GF-5 Resource Conserving specifications.\nDesigned to cater to a wide array of petrol and four-stroke engines that operate under diverse and challenging conditions – from low-temperature stop-and-go driving to high-temperature motorway cruising – EVOLUTION 5W/30 SN GF-5 is the go-to choice.\nThis semi-synthetic formulation is enriched with carefully selected additives, delivering an oil with exceptional resistance to oxidation. This quality is instrumental in countering the higher internal engine operating temperatures, which, in turn, reduces engine deposits while enhancing protection for essential components such as pistons and turbochargers.\nEVOLUTION 5W/30 SN GF-5 distinguishes itself with an elevated level of dispersants and detergents. This results in robust sludge control across all service conditions. Additionally, it incorporates friction modifiers, which effectively manage internal engine friction, contributing to improved fuel economy.\nFurthermore, this lubricant is engineered with a reduced use of components known to shorten catalyst life, thereby aligning with the stricter emissions standards while extending the durability of emissions systems. In summary, EVOLUTION 5W/30 SN GF-5 is a top-tier lubricant that delivers on multiple fronts: engine protection, fuel efficiency, and emissions compliance.\nAlways consult your vehicle owner’s manual for the manufacturer’s recommendations.\nSemi-Synthetic Base Oils: Crafted from a blend of high-quality synthetic and mineral base oils, it extends the life of the lubricant while delivering exceptional cold start-up protection.\nLow Speed Pre-Ignition (LSPI): It meets the API SN Plus performance level, specially tailored to combat Low-Speed Pre-Ignition (LSPI) and mitigate timing chain wear in small turbocharged petrol engines.\nOxidation/Corrosion Resistance: This lubricant surpasses the API SN Plus oxidation requirements, as demonstrated in the TEOST MHT Deposit Formation test. It also excels in corrosion resistance, exceeding the benchmarks in the Sequence VIII Bearing Weight Loss test and the Sequence VG Engine Sludge and Oil Screen Clogging test.\nCam Wear Protection: EVOLUTION 5W/30 SN GF-5 goes above and beyond, exceeding the API SN Plus Sequence IVA Average Cam Wear Limit by a significant margin. This contributes to promoting longer engine life, with cam wear results measuring less than 20μm, compared to the API SN limit of a maximum 90μm.\nEmission Control: It meets the stringent modern emissions standards while ensuring extended emissions system durability.\nCatalytic Converter Protection: This lubricant has undergone the Sequence IIIGB test, a standard test for the API SN Plus Resource Conserving performance level. This test measures the percentage of Phosphorus retained in the engine oil. The controlled leaching of Phosphorus from the oil is crucial in preventing the poisoning and clogging of catalytic converters in the vehicle exhaust system.\nFuel Efficiency: EVOLUTION 5W/30 SN GF-5 meets the ILSAC GF5 and API SN Plus Resource Conserving performance requirements. It incorporates technology to manage internal friction effectively, resulting in improved fuel economy and reduced maintenance costs. Its performance in the Sequence VID test for Improved Fuel Efficiency, with a gain of over 1.9%, and the Sequence IIIG Oil Thickening and Cam Lifter Wear further support these claims. This makes EVOLUTION 5W/30 SN GF-5 an outstanding choice for engine protection, fuel efficiency, and emissions compliance.\nEVOLUTION 5W/30 SN GF-5 meets the following specifications:\nAPI: SN Plus, SN, SM, SL, SJ, SH\nAPI Resource Conserving\nILSAC: GF-5, GF-4, GF-3\nAlways consult your vehicle owner’s manual for the manufacturer’s lubricant recommendations.\n|Density (kg/Lt) @ 15oC\n|Viscosity (cSt) @ 100°C\n|Flash Point (°C)\n|Pour Point (°C)\n|Foam, Seq I, II, III (after settling)\n|0, 0, 0\n|Cold Cranking Simulator @ -30°C\n|TBN (mg KOH/g)\nAvailable in: Bulk, 200 Litres, 20 Litres and 5 Litres\nItem code: VI1-2117", "domain": "chemistry", "round": 3} +{"url": "https://www.fuyangsweetener.com/sale-14340471-iso22000-so-nourished-powdered-erythritol-sweetener-diabetes-friendly-green-and-healthy.html", "date": "2022-10-01T20:09:40Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-40/segments/1664030336921.76/warc/CC-MAIN-20221001195125-20221001225125-00648.warc.gz", "language_score": 0.668413519859314, "token_count": 535, "dump": "CC-MAIN-2022-40", "global_id": "webtext-fineweb__CC-MAIN-2022-40__0__19540888", "lang": "en", "text": "|PH Value:||5.0~7.0||Odour:||Sweet Taste|\nISO22000 So Nourished Powdered Erythritol Sweetener,\nISO22000 So Nourished Powdered Erythritol Sweetener Diabetes,\nISO22000 substitute for powdered erythritol sweetener\nOrganic Erythritol Sugar Erythritol Powder\nErythritol is a type of sugar alcohol. But it's not the type of alcohol to make you tipsy! Erythritol comes from fermenting starch by using yeast. It can be obtained from certain plants and fruits as well and is a sweet alternative to table sugar.\nOur bodies can’t break down erythritol during digestion. Fortunately, that is an excellent benefit for us because it can’t be converted to glucose, meaning it doesn’t increase blood sugar levels.2 Additionally, since our bodies can’t break it down, this means that it offers no calories and is considered 0 net carbs! It ranks in at a zero on the glycemic index. Finally, oral bacteria cannot metabolize it, which prevents tooth decay, unlike sugar.\n|Place of Origin||China,Shandong|\n|Brand Name||SO TURE|\n|Model Number||Chewing Gum Bases, Sweeteners|\n|Appearance||White crystalline or powder|\n|Model Number||30-60mesh or as per customer's requirement|\nContact Person: admine", "domain": "chemistry", "round": 3} +{"url": "https://afb.zodiac.nl/en/catalog/19-gas-tank-and-instrument/gas-tank-and-instrument/fuel-catalyst/fitch-fuel-catalyst/", "date": "2019-11-14T09:24:18Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-47/segments/1573496668334.27/warc/CC-MAIN-20191114081021-20191114105021-00548.warc.gz", "language_score": 0.9608399271965027, "token_count": 257, "dump": "CC-MAIN-2019-47", "global_id": "webtext-fineweb__CC-MAIN-2019-47__0__94903072", "lang": "en", "text": "Most fuel is made up of high-energy constituents, which burn with a fairly high degree of efficiency. However, in addition to these high-energy fuel constituents, there are others, which tend to cause problems during the combustion process. These are the lighter components, which burn too fast at the beginning of the combustion process causing pre-ignition and the heavier ones, which burn too slowly at the end of the process causing both excessive smoke and carbon buildup. The Fitch Fuel Catalyst acts on both of these problem fuel components, insuring that they burn with the same efficiency as the rest of the fuel. All forms of Power Sports equipment such as motorcycles, ATV's, snowmobiles and personal watercraft can benefit from the Fitch Fuel Catalyst. Once the Fitch Fuel Catalyst is installed the treated fuel will begin to burn more completely resulting in a cleaner, better running engine that will start easier, burn less fuel and increase power and performance. The Fitch Fuel Catalyst helps keep your fuel fresh during the off-season and eliminates the need for stabilizers and other additives. The fuel catalyst is warranted for 350.000 km or 5.000 operating hours, effectively the life of your engine. Comes in a package of two for both single and dual tankhalve applications.", "domain": "chemistry", "round": 3} +{"url": "https://www.mdpi.com/2073-4409/8/10/1263", "date": "2021-01-16T00:55:41Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-04/segments/1610703497681.4/warc/CC-MAIN-20210115224908-20210116014908-00191.warc.gz", "language_score": 0.8670044541358948, "token_count": 337, "dump": "CC-MAIN-2021-04", "global_id": "webtext-fineweb__CC-MAIN-2021-04__0__135600827", "lang": "en", "text": "The establishment and maintenance of ion gradients between the interior of lysosomes and the cytosol are crucial for numerous cellular and organismal functions. Numerous ion transport proteins ensure the required variation in luminal concentrations of the different ions along the endocytic pathway to fit the needs of the organelles. Failures in keeping proper ion homeostasis have pathological consequences. Accordingly, several human diseases are caused by the dysfunction of ion transporters. These include osteopetrosis, caused by the dysfunction of Cl−\nexchange by the lysosomal transporter ClC-7. To better understand how chloride transport affects lysosomal ion homeostasis and how its disruption impinges on lysosomal function, we developed a mathematical model of lysosomal ion homeostasis including Ca2+\ndynamics. The model recapitulates known biophysical properties of ClC-7 and enables the investigation of its differential activation kinetics on lysosomal ion homeostasis. We show that normal functioning of ClC-7 supports the acidification process, is associated with increased luminal concentrations of sodium, potassium, and chloride, and leads to a higher Ca2+\nuptake and release. Our model highlights the role of ClC-7 in lysosomal acidification and shows the existence of differential Ca2+\ndynamics upon perturbations of Cl−\nexchange and its activation kinetics, with possible pathological consequences.\nThis is an open access article distributed under the Creative Commons Attribution License\nwhich permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited", "domain": "chemistry", "round": 3} +{"url": "http://www.ingentaconnect.com/content/klu/jem/2006/00000035/00000002/art00018", "date": "2014-03-16T21:00:59Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2014-10/segments/1394678703748/warc/CC-MAIN-20140313024503-00043-ip-10-183-142-35.ec2.internal.warc.gz", "language_score": 0.8664736151695251, "token_count": 456, "dump": "CC-MAIN-2014-10", "global_id": "webtext-fineweb__CC-MAIN-2014-10__0__49890970", "lang": "en", "text": "Intermetallic Reactions in Sn3Ag0.5Cu and Sn3Ag0.5Cu0.06Ni0.01Ge Solder BGA Packages with Au/Ni Surface Finishes\nAuthors: Chuang, T.H.; Yen, S.F.; Cheng, M.D.\nSource: Journal of Electronic Materials, Volume 35, Number 2, February 2006 , pp. 302-309(8)\nAbstract:The intermetallic compounds (IMCs) formed during the reflow and aging of Sn3Ag0.5Cu and Sn3Ag0.5Cu0.06Ni0.01Ge solder BGA packages with Au/Ni surface finishes were investigated. After reflow, the thickness of (Cu, Ni, Au)6Sn5 interfacial IMCs in Sn3Ag0.5Cu0.06Ni0.01Ge was similar to that in the Sn3Ag0.5Cu specimen. The interiors of the solder balls in both packages contained Ag3Sn precipitates and brick-shaped AuSn4 IMCs. After aging at 150°C, the growth thickness of the interfacial (Ni, Cu, Au)3Sn4 intermetallic layers and the consumption of the Ni surface-finished layer on Cu the pads in Sn3Ag0.5Cu0.06Ni0.01Ge solder joints were both slightly less than those in Sn3Ag0.5Cu. In addition, a coarsening phenomenon for AuSn4 IMCs could be observed in the solder matrix of Sn3Ag0.5Cu, yet this phenomenon did not occur in the case of Sn3Ag0.5Cu0.06Ni0.01Ge. Ball shear tests revealed that the reflowed Sn3Ag0.5Cu0.06Ni0.01Ge packages possessed bonding strengths similar to those of the Sn3Ag0.5Cu. However, aging treatment caused the ball shear strength in the Sn3Ag0.5Cu packages to degrade more than that in the Sn3Ag0.5Cu0.06Ni0.01Ge packages.\nDocument Type: Regular Paper\nPublication date: February 1, 2006", "domain": "chemistry", "round": 3} +{"url": "https://rgw.arizona.edu/compliance/RLSS/biosafety-program/centrifuge", "date": "2020-02-25T16:18:11Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-10/segments/1581875146123.78/warc/CC-MAIN-20200225141345-20200225171345-00414.warc.gz", "language_score": 0.8667352199554443, "token_count": 450, "dump": "CC-MAIN-2020-10", "global_id": "webtext-fineweb__CC-MAIN-2020-10__0__137074925", "lang": "en", "text": "Hazards associated with centrifuging include mechanical failure (e.g. rotor failure, tube or bucket failure) and the creation of aerosols. To minimize the risk of mechanical failure, centrifuges must be maintained and used according to the manufacturer's instructions, and users must be properly trained. The greatest aerosol hazard is created if a tube breaks during centrifugation. To minimize the generation of aerosols when centrifuging BSL-2 or BSL-3 agents, the following procedures are required:\n- Use sealed tubes, safety cups, or sealed rotors that seal with O-rings. Before use, inspect tubes, O-rings and buckets for cracks, chips, erosions, bits of broken glass, etc. Do not use aluminum foil to cap centrifuge tubes because it may detach or rupture during centrifugation.\n- Open sealed tubes, safety cups, or sealed rotors inside a BSC.\n- Avoid overfilling centrifuge tubes. After tubes are filled and sealed, wipe them down with disinfectant.\n- Do not decant or pour off supernatant of tubes containing biohazardous materials. Use a vacuum system with appropriate in-line reservoirs and filters inside of a BSC.\n- Work in a BSC when resuspending sedimented material from a biohazardous source. Use a swirling rotary motion rather than shaking. If shaking is necessary, wait a few minutes to permit the aerosol to settle before opening the tube.\n- Small low-speed centrifuges may be placed in a biosafety cabinet during use to reduce the aerosol escape. High-speed centrifuges pose additional hazards. Precautions must be taken to filter the exhaust air from vacuum lines. Manufacturer recommendations must be meticulously followed to avoid metal fatigue, distortion, and corrosion.\n- Avoid the use of celluloid (cellulose nitrate) tubes with biohazardous materials. Celluloid centrifuge tubes are highly flammable and prone to shrinkage with age. They distort on boiling and can be highly explosive in an autoclave. If celluloid tubes must be used, an appropriate chemical disinfectant must be used to decontaminate them.", "domain": "chemistry", "round": 3} +{"url": "http://www.techuniq.com/2017/05/25/aldolase-c-is-a-brain-specific-glycolytic-isozyme-whose-complete-repertoire-of/", "date": "2024-04-14T08:52:23Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712296816875.61/warc/CC-MAIN-20240414064633-20240414094633-00651.warc.gz", "language_score": 0.9243709444999695, "token_count": 1115, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__164228317", "lang": "en", "text": "Aldolase C is a brain-specific glycolytic isozyme whose complete repertoire of features are obscure. the specificity of 9F for aldolase C. After that using bioinformatic equipment combined to molecular cloning and chemical substance synthesis techniques we created truncated human being aldolase C fragments and evaluated 9F binding to these fragments by traditional western blot and ELISA assays. This plan exposed that residues 85-102 harbor the epitope-containing area Saquinavir identified by 9F. The efficiency of 9F was proven for immunoprecipitation assays also. Finally surface area plasmon resonance exposed how the protein includes a high affinity toward the epitope-containing peptide. Used collectively our results display that epitope reputation is is and sequence-driven in addition to the three-dimensional framework. In conclusion provided its particular molecular discussion 9 can be a book and powerful device to research aldolase C’s features in the mind. BL21DE3 cells. The recombinant item was also utilized as check antigen to verify the immunoreactivity from the mAb clones. The clone displaying the most powerful immunoreactive sign was chosen within the complete arranged: its identification code was 9F1B5 and it is herein known as anti-aldolase C 9F mAb. The technique used to get ready the -panel of screened antibodies is dependant on mouse hybridoma advancement and it is under patent (ProMab Biotechnologies Inc.). Cell tradition and plasmids transfection The cell lines useful for transfection tests had been Neuro2a (mouse neuroblastoma from CEINGE Cell Loan company Naples Italy) and HEK293 (human being embryonic kidney). Cells were maintained stored and sub-cultured based on the guidelines of Deutsche Sammlung von. Mikroorganismen und Zellkulturen GmbH. Moderate structure: 87% Dulbecco’s customized Eagle’s moderate (Sigma) 10 FBS (HyClone) 2 ultra-glutamine (Lonza) 1 nonessential proteins (Gibco). 1 day before transfection cells had been plated in development moderate (without antibiotics) to secure a 70-90% confluence during transfection. Cells had been transfected with lipofectamine 2000 (Invitrogen) based on the manufacturer’s guidelines and incubated at 37 °C inside a CO2 incubator for 48h Saquinavir ahead of tests for transgene manifestation. The culture medium was changed 6h after transfection. All clones transfected with this research are detailed in Dining tables S1 and S2 alongside the manifestation plasmids as well as the primer pairs found in the cloning treatment. Protein removal from cells and cells Cells and cells had been washed double with cool PBS and lysed for 30 min on snow in lysis Saquinavir buffer (50mM TRIS-HCl pH 7.5 150 NaCl 0.1% Triton X-100 0.5 mM PMSF). Before lysis cells had been dissociated to acquire cells inside a dounce homogenizer having a tight-fitting cup Saquinavir pestle. Lysates had been clarified by centrifugation at 16000xg for 30min at 4 °C within an Eppendorf microcentrifuge and the full total protein focus was established with traditional Bradford technique.38 Western blotting Protein extracts were resolved on SDS-PAGE gels and transferred onto nitrocellulose membranes (GE Healthcare RPN1520D) at 200mA for 90min in 1X Transfer Buffer (25mM Tris 192 glycine 10 methanol). After transfer membranes had been stained with Ponceau way to verify the effectiveness from the blotting procedure and incubated for 1h in Saquinavir obstructing solution (5% nonfat dry dairy [Biorad 170 in PBS pH 7.6 containing 0.1% Tween-20 [T-PBS]) to avoid nonspecific binding. Membranes had been after that incubated for 1h at space temperatures (RT) or over night (4 °C) with particular major antibodies (9F mAb 1 α-FLAG 1 α-GFP 1 diluted in obstructing option. After three washes with T-PBS membranes Saquinavir had been incubated 45min at RT having a horseradish peroxidase-conjugated supplementary antibody (anti-mouse 1:5000; anti-rabbit 1:5000; GE Health Tsc2 care). A mouse anti-α-tubulin major antibody (1:2000) was often used as launching control. Immunoblots had been developed by improved chemiluminescence (ECL) using Amersham ECL Traditional western Blotting Recognition Reagents (GE Health care RPN2106). ELISA assay of biotinylated peptides For ELISA assays aldolase C peptides appealing had been synthesized having a biotin combined with their N-terminus and immobilized on a good stage by streptavidin catch. Peptide quality was managed after chemical substance synthesis by mass spectrometry (ESI ion capture amaZonSL Bruker Daltonics managed in positive ion setting) and resulted.", "domain": "chemistry", "round": 3} +{"url": "https://scholars.duke.edu/display/pub789864", "date": "2023-05-29T09:47:22Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-23/segments/1685224644817.32/warc/CC-MAIN-20230529074001-20230529104001-00067.warc.gz", "language_score": 0.8134084343910217, "token_count": 588, "dump": "CC-MAIN-2023-23", "global_id": "webtext-fineweb__CC-MAIN-2023-23__0__179715320", "lang": "en", "text": "Downregulation of adipose glutathione S-transferase A4 leads to increased protein carbonylation, oxidative stress, and mitochondrial dysfunction.\nJournal Article (Journal Article)\nObjectivePeripheral insulin resistance is linked to an increase in reactive oxygen species (ROS), leading in part to the production of reactive lipid aldehydes that modify the side chains of protein amino acids in a reaction termed protein carbonylation. The primary enzymatic method for lipid aldehyde detoxification is via glutathione S-transferase A4 (GSTA4) dependent glutathionylation. The objective of this study was to evaluate the expression of GSTA4 and the role(s) of protein carbonylation in adipocyte function.\nResearch design and methodsGSTA4-silenced 3T3-L1 adipocytes and GSTA4-null mice were evaluated for metabolic processes, mitochondrial function, and reactive oxygen species production. GSTA4 expression in human obesity was evaluated using microarray analysis.\nResultsGSTA4 expression is selectively downregulated in adipose tissue of obese insulin-resistant C57BL/6J mice and in human obesity-linked insulin resistance. Tumor necrosis factor-alpha treatment of 3T3-L1 adipocytes decreased GSTA4 expression, and silencing GSTA4 mRNA in cultured adipocytes resulted in increased protein carbonylation, increased mitochondrial ROS, dysfunctional state 3 respiration, and altered glucose transport and lipolysis. Mitochondrial function in adipocytes of lean or obese GSTA4-null mice was significantly compromised compared with wild-type controls and was accompanied by an increase in superoxide anion.\nConclusionsThese results indicate that downregulation of GSTA4 in adipose tissue leads to increased protein carbonylation, ROS production, and mitochondrial dysfunction and may contribute to the development of insulin resistance and type 2 diabetes.\n- Curtis, JM; Grimsrud, PA; Wright, WS; Xu, X; Foncea, RE; Graham, DW; Brestoff, JR; Wiczer, BM; Ilkayeva, O; Cianflone, K; Muoio, DE; Arriaga, EA; Bernlohr, DA\n- May 2010\nVolume / Issue\n- 59 / 5\nStart / End Page\n- 1132 - 1142\nPubmed Central ID\nElectronic International Standard Serial Number (EISSN)\nInternational Standard Serial Number (ISSN)\nDigital Object Identifier (DOI)", "domain": "chemistry", "round": 3} +{"url": "https://journals.lww.com/neuroreport/Abstract/1995/08000/Nitric_oxide_modulates_blood_brain_barrier.10.aspx", "date": "2023-02-02T17:39:34Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-06/segments/1674764500035.14/warc/CC-MAIN-20230202165041-20230202195041-00732.warc.gz", "language_score": 0.9235251545906067, "token_count": 297, "dump": "CC-MAIN-2023-06", "global_id": "webtext-fineweb__CC-MAIN-2023-06__0__237597975", "lang": "en", "text": "Research Paper: PDF OnlyNitric oxide modulates blood-brain barrier permeability during infections with an inactivated bacteriumShukla, A.; Dikshit, M.; Srimal, R. C.1 Author Information Department of Pharmacology, Central Drug Research Institute, Lucknow 226001, India 1Industrial Toxicology Research Centre, Lucknow 226001, India0 NeuroReport 6(12):p 1629-1632, August 1995. Buy Abstract The objective of the present investigation was to study the involvement of NO in regulating the permeability of the blood-brain barrier (BBB) during infections, since NOS is known to be induced following infections. The administration of inactivated Escherichia coli (a source of lipopolysaccharide) or poly (I:C), an interferon inducer, to rats increased the permeability of BBB significantly. This increase was found to be potentiated in the presence of L-arginine, a substrate for NOS, while D-arginine had no such effect. N-nitro L-arginine methyl ester, an inhibitor of NOS, and dexamethasone, an inhibitor of NOS induction, blocked the E. coli-induced effects. These results suggest that during infections, NOS inductions causes the release of large quantities of NO, resulting in increased BBB permeability. © Lippincott-Raven Publishers.", "domain": "chemistry", "round": 3} +{"url": "https://onepetro.org/ARMACUPB/proceedings-abstract/CUPB19/All-CUPB19/ARMA-CUPB-19-6272/125165", "date": "2022-05-17T07:39:36Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-21/segments/1652662517018.29/warc/CC-MAIN-20220517063528-20220517093528-00272.warc.gz", "language_score": 0.8576127290725708, "token_count": 341, "dump": "CC-MAIN-2022-21", "global_id": "webtext-fineweb__CC-MAIN-2022-21__0__319833193", "lang": "en", "text": "To probe mechanisms of the controls of mineral composition on fault friction, stability and dilation properties during reservoir stimulation, simulated fault gouges comprising powdered samples of major reservoir rocks in China were sheared in double direct shear configuration under water-saturated conditions at room temperature. The samples span a range of phyllosilicate contents from 0 to 30 wt.% and with grain sizes <150 µm. Velocity-stepping tests were performed to assess the key friction parameters at three different normal stresses. Experimental results show that the phyllosilicate minerals have a strong influence on gouge friction, stability and dilation properties. The friction coefficient decreases monotonically with increasing phyllosilicate contents and the frictional stability parameter (a – b) increases with an increase in phyllosilicate content with a transition from velocity weakening to velocity strengthening behavior at 15 wt.% phyllosilicate content. Gouge dilation is observed upon a change in shearing velocity and may be used as a proxy for permeability evolution in gouge-filled faults. The dilation scales positively with friction coefficient and negatively with frictional stability parameter (a – b). The above results provide insight in understanding the potential for induced seismicity and permeability evolution during reservoir stimulation.\nMineralogy-controlled friction, stability and dilation properties for major reservoir rocks in China\nAn, M., Zhang, F., and D. Elsworth. \"Mineralogy-controlled friction, stability and dilation properties for major reservoir rocks in China.\" Paper presented at the ARMA-CUPB Geothermal International Conference, Beijing, China, August 2019.\nDownload citation file:", "domain": "chemistry", "round": 3} +{"url": "http://www.abcam.com/histone-h3-mono-methyl-r2-antibody-chip-grade-ab15584-references.html", "date": "2017-07-27T00:47:20Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-30/segments/1500549426693.21/warc/CC-MAIN-20170727002123-20170727022123-00268.warc.gz", "language_score": 0.6558399796485901, "token_count": 272, "dump": "CC-MAIN-2017-30", "global_id": "webtext-fineweb__CC-MAIN-2017-30__0__217440900", "lang": "en", "text": "Publishing research using ab15584? Please let us know so that we can cite the reference in this datasheet.\nab15584 has been referenced in 5 publications.\nMajocchi S et al.Epigenetic regulatory elements associate with specific histone modifications to prevent silencing of telomeric genes.Nucleic Acids Res N/A:N/A (2013).\nChignola F et al.The solution structure of the first PHD finger of autoimmune regulator in complex with non-modified histone H3 tail reveals the antagonistic role of H3R2 methylation.Nucleic Acids Res 37:2951-61 (2009).\nIberg AN et al.Arginine methylation of the histone h3 tail impedes effector binding.J Biol Chem 283:3006-10 (2008).\nBarski A et al.High-resolution profiling of histone methylations in the human genome.Cell 129:823-37 (2007).\nChang B et al.JMJD6 is a histone arginine demethylase.Science 318:444-7 (2007).\nPlease note: All products are \"FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE\"", "domain": "chemistry", "round": 3} +{"url": "https://ohsu.pure.elsevier.com/en/publications/characterization-of-human-%CE%B2-crystallin-subunits-in-newborn-human--2", "date": "2022-07-05T13:54:22Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-27/segments/1656104576719.83/warc/CC-MAIN-20220705113756-20220705143756-00060.warc.gz", "language_score": 0.9519104361534119, "token_count": 464, "dump": "CC-MAIN-2022-27", "global_id": "webtext-fineweb__CC-MAIN-2022-27__0__102363400", "lang": "en", "text": "Purpose: To determine the previously unknown sequences of human β-crystallins, correct the errors in previously reported sequences, confirm these sequences by mass spectrometric analysis, and characterize truncated forms of β-crystallins present at birth. Methods: Crystallins were isolated from donors of less than one week of age and identified by a combination of 2-dimensional electrophoresis and Edman sequencing. Either partial or full length cDNAs of the newly identified crystallins were sequenced and the masses of their deduced amino acid sequences were confirmed by mass spectrometry. Crystallins were prepared for mass spectrometry by either gel filtration and reversed phase chromatography or by electroelution from 2-dimensional gels. Results: The positions of all major human crystallins were determined on 2dimensional gels. Newly identified crystallins included: βAl, βA3, βA4, and βB3. The full length cDNA of βA4, 5' region of βB3 cDNA, and corrected sequence of βA3/Al cDNA were determined. The resulting deduced amino acid sequences were then confirmed by mass spectrometry. A partially truncated form of βA3, missing 22 residues from its N-terminus was also detected by Edman sequencing and then confirmed by mass spectrometry. Conclusions: Conformation of the presence and correct primary structure of all human β-crystallins will allow examination of the age related changes in these proteins. βA3/Al, as well as βBl are the most proteolytically labile crystallin subunits in the human lens. Modified forms of both proteins are already present at birth. Cleavage of both proteins between asparagine and proline residues in their N-terminal extensions suggested that a single proteolytic activity may be responsible.\n|Original language||English (US)|\n|Journal||Investigative Ophthalmology and Visual Science|\n|State||Published - Dec 1 1997|\nASJC Scopus subject areas\n- Sensory Systems\n- Cellular and Molecular Neuroscience", "domain": "chemistry", "round": 3} +{"url": "http://agent3155.com/approaches-to-repair-an-epoxy-floor-wikihow/", "date": "2020-09-29T10:08:05Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-40/segments/1600401641638.83/warc/CC-MAIN-20200929091913-20200929121913-00797.warc.gz", "language_score": 0.9512258768081665, "token_count": 457, "dump": "CC-MAIN-2020-40", "global_id": "webtext-fineweb__CC-MAIN-2020-40__0__288913885", "lang": "en", "text": "As the smoke dries and its components undergo the evaporation procedure, the odour connected with paint will fade along with the risks of inhaling its fumes can diminish. Paint fumes are very poisonous for your own lungs, from inhaling these poisonous fumes inside a short period of 28, and you may begin feeling symptoms nearly immediately. Be sure that you wear protective clothing and eyewear when you are ready to start. Paint a liquid will evaporate over time the same as every liquid. Acetone is a colourless, flammable liquid which may be used for eliminating dry or harmful epoxy in some other surfaces that are contaminated, brushes or tools. There are options for cleansing areas of skin or any other surfaces that come with hardener or resins.\nAlcohol and white vinegar is a secure and effective way of cleansing from the skin. Fumes from smoke can be quite dangerous since they can result in symptoms of nausea, vomiting, nausea and death. After studying each, the aforementioned one needs to ask why do you select glue around your house or work area not only is it full of fumes its toxins? You are currently in a quandary about what to do use as a substitute around your house or workplace. These are the drawbacks of getting the floors in your property. Contact us now to explore the flooring choices and then be on the road to using this space that is long-wasted! For more https://sonsanepoxy.vn/\nThis is the better method for surface prep when employing coatings, although maybe not the ideal option when employing paint or sandpaper. It’s ideal for making an atmosphere which will create the smoke paint to dry quickly. Darker colours of sandpaper have hardeners. Why epoxy isn’t that bad, I have explained. Everyone should beware of a frequent problem called”amine blush” when painting some surface with paint. This issue is widespread in more economical epoxies and can normally be prevented by buying a greater quality of paint. Epoxy Paint Warning that you might be spending more than cash? Powders: PCS can offer fusion bonded epoxy from many producers; one of the two largely employed are Axalta and 3M.", "domain": "chemistry", "round": 3} +{"url": "https://typeost.com/is-borax-safe-to-use-in-laundry/", "date": "2023-10-01T22:32:56Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233510941.58/warc/CC-MAIN-20231001205332-20231001235332-00696.warc.gz", "language_score": 0.9601776599884033, "token_count": 637, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__79908769", "lang": "en", "text": "Laundry is an essential part of our daily routine. We all want to keep our clothes clean and fresh-smelling. However, with so many laundry detergents available in the market, it can be challenging to choose the right one. One such product that has gained popularity over the years is borax. Borax is a naturally occurring mineral that is used as a laundry booster. But is it safe to use in laundry? Let’s find out.\nWhat is Borax?\nBorax is a white, powdery substance that is naturally found in the earth’s crust. It is also known as sodium borate, sodium tetraborate, or disodium tetraborate. It has been used for centuries for various purposes, including cleaning, laundry, and insect control.\nHow Does Borax Work?\nBorax works as a laundry booster by increasing the alkalinity of the water. This helps to break down dirt and stains on clothes, making them easier to wash away. Borax also helps to soften hard water, which can improve the effectiveness of laundry detergents.\nIs Borax Safe to Use in Laundry?\nBorax is generally considered safe to use in laundry. However, it is important to follow the manufacturer’s instructions and not to use too much borax. Using too much borax can cause skin irritation, especially for people with sensitive skin. It is also important to keep borax out of reach of children and pets as it can be toxic if ingested.\nBenefits of Using Borax in Laundry\nUsing borax in laundry has several benefits. It can help to remove tough stains, brighten clothes, and eliminate odors. Borax can also help to extend the life of your clothes by keeping them looking newer for longer. Additionally, borax is an eco-friendly alternative to many laundry detergents as it is a natural and biodegradable substance.\nHow to Use Borax in Laundry\nTo use borax in laundry, add ½ cup of borax to your washing machine along with your regular laundry detergent. For heavily soiled clothes, you can add up to 1 cup of borax. It is important not to overload your washing machine and to use the appropriate amount of water for your load size.\nAlternatives to Borax\nIf you are concerned about using borax in your laundry, there are several alternatives you can try. Baking soda and washing soda are both natural laundry boosters that can help to remove stains and odors. Vinegar is also a great alternative that can help to soften clothes and eliminate odors.\nIn conclusion, borax is generally considered safe to use in laundry. However, it is important to use it correctly and not to use too much. If you are concerned about using borax, there are several natural alternatives you can try. Whichever laundry booster you choose, be sure to follow the manufacturer’s instructions and keep it out of reach of children and pets.", "domain": "chemistry", "round": 3} +{"url": "https://www.astm.org/Standards/D7472.htm", "date": "2019-04-25T20:38:18Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-18/segments/1555578733077.68/warc/CC-MAIN-20190425193912-20190425215912-00559.warc.gz", "language_score": 0.8391837477684021, "token_count": 877, "dump": "CC-MAIN-2019-18", "global_id": "webtext-fineweb__CC-MAIN-2019-18__0__143694688", "lang": "en", "text": "| ||Format||Pages||Price|| |\n|3||$42.00||  ADD TO CART|\n|Hardcopy (shipping and handling)||3||$42.00||  ADD TO CART|\nThis specification addresses the physical properties of melt processible molding and extrusion materials of EFEP-fluoropolymer, wherein the EFEP resin is a copolymer of ethylene, tetrafluoroethylene, and hexafluoropropylene. It does not cover blended and recycled materials. Covered here are two types of fluoropolymer that is supplied in pellet form and classified according to their melting points, while the resins of each type are divided into one to two grades in accordance with their melt flow rates. The materials shall be sampled in accordance with an adequate statistical sampling procedure and shall conform to specific gravity, melting point, melt flow rate, elongation, tensile strength, and dielectric constant and dissipation factor requirements when tested by the procedures itemized herein.\nThis abstract is a brief summary of the referenced standard. It is informational only and not an official part of the standard; the full text of the standard itself must be referred to for its use and application. ASTM does not give any warranty express or implied or make any representation that the contents of this abstract are accurate, complete or up to date.\n1.1 This specification covers melt processible molding and extrusion materials of EFEP-fluoropolymer. The EFEP resin is a copolymer of ethylene, tetrafluoroethylene, and hexafluoropropylene.\n1.2 This specification does not cover blended materials and does not cover recycled materials.\n1.3 The values stated in SI units as detailed in IEEE/ASTM SI-10 are to be regarded as the standard. The values given in parentheses are for information only.\n1.4 The following safety hazards caveat pertains only to the test method portion, Section 11, of this specification.This standard does not purport to address all of the safety concerns, if any, associated with its use. It is the responsibility of the user of this standard to establish appropriate safety and health practices and determine the applicability of regulatory limitations prior to use.\n2. Referenced Documents (purchase separately) The documents listed below are referenced within the subject standard but are not provided as part of the standard.\nD150 Test Methods for AC Loss Characteristics and Permittivity (Dielectric Constant) of Solid Electrical Insulation\nD618 Practice for Conditioning Plastics for Testing\nD638 Test Method for Tensile Properties of Plastics\nD792 Test Methods for Density and Specific Gravity (Relative Density) of Plastics by Displacement\nD883 Terminology Relating to Plastics\nD1238 Test Method for Melt Flow Rates of Thermoplastics by Extrusion Plastometer\nD1600 Terminology for Abbreviated Terms Relating to Plastics\nD3418 Test Method for Transition Temperatures and Enthalpies of Fusion and Crystallization of Polymers by Differential Scanning Calorimetry\nD3892 Practice for Packaging/Packing of Plastics\nE177 Practice for Use of the Terms Precision and Bias in ASTM Test Methods\nISO StandardsISO 12086-1 Plastics--Fluoropolymer Dispersions and Moulding and Extrusion Materials--Part 1 ISO 12086-2 Plastics--Fluoropolymer Dispersions and Moulding and Extrusion Materials--Part 2\nICS Number Code 83.080.20 (Thermoplastic materials)\nUNSPSC Code 13100000(Rubber and elastomers)\nUNSPSC Code 13111007(Fluoropolymer resin)\n|Link to Active (This link will always route to the current Active version of the standard.)|\nASTM D7472-09(2014), Standard Specification for EFEP-Fluoropolymer Molding and Extrusion Materials, ASTM International, West Conshohocken, PA, 2014, www.astm.orgBack to Top", "domain": "chemistry", "round": 3} +{"url": "https://aquaplantscare.uk/shop/aquatic-plants-fertiliser/mn-13-edta-chelated/", "date": "2024-03-04T21:12:04Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707947476532.70/warc/CC-MAIN-20240304200958-20240304230958-00222.warc.gz", "language_score": 0.9433529376983643, "token_count": 335, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__121236606", "lang": "en", "text": "Manganese, Mn 13% EDTA Chelated\nManganese is a microelement; dry plant contains approximately 50 mg of manganese per every kg. This element is an activator and a building block of many enzymes. It is also necessary in the process of oxygen production during photosynthesis. Manganese is a middle element when it come to its mobility. Manganese is absorbed by plants in the form of ions Mn(2+). The most commonly used source of this element is Mn-EDTA.\nDepending on the type of plant, the symptoms of its deficiency may become first apparent on the young, middle or older leaves (which makes the diagnosis more difficult). With time, the symptoms may spread throughout the whole plant. The symptoms are: inhibition of growth, interveinal chlorosis on leaves (in severe cases leaves may even turn white) – however there is no clear contrast between the affected areas and the veins. White or yellow smears or brown or black spots may also appear. In more severe cases, necrosis-like spots or necrosis of the leaves’ edges may be present. Leaves may fall. The plants may also produce noticeable ‘bubbles’\nSymptoms usually are noticeable in the leaves located in the lower and middle parts of the plant. At the beginning, the symptoms my resemble manganese deficiency symptoms. Brown, black or red spots on leaves may turn to necrosis with time. Some sources report unequal distribution of chlorophyll leading to chlorosis and necrosis. The roots’ growth may be also inhibited. The excess of manganese may also lead to iron deficiency.", "domain": "chemistry", "round": 3} +{"url": "https://www.eventscribe.com/2020/SLAS2020/fsPopup.asp?efp=WEZJSlpFQlc2OTg3&PresentationID=635503&rnd=0.308232&mode=presinfo", "date": "2021-12-08T19:59:11Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-49/segments/1637964363520.30/warc/CC-MAIN-20211208175210-20211208205210-00229.warc.gz", "language_score": 0.9131001234054565, "token_count": 545, "dump": "CC-MAIN-2021-49", "global_id": "webtext-fineweb__CC-MAIN-2021-49__0__9586510", "lang": "en", "text": "High throughput screening (HTS) cascades have evolved to ensure that high quality hits can be identified from large screening collections. Traditionally, most primary screens focus on the identification of modulators of catalytically active sites, while target engagement assays are placed further down the cascade. Well established technologies like competition-based assays, affinity selection technologies or differential scanning fluorimetry (DSF) depend on availability of protein which is tested in a non-native biochemical setting. Therefore, one of the main concerns when initiating an HTS cascade remains the demonstration of target interaction within a relevant cellular environment. The use of cellular assays during primary screening and the HTS cascade presents an alternative. However, cell-based screens can easily become very complex, risk off-target effects and thus often require time consuming target deconvolution of pathway hitters. To date there has been no single technology that can demonstrate cellular target engagement in a suitable format for HTS primary screening. The cellular thermal shift assay (CETSA®) can act as an interface between this classic biochemical-cellular screening dichotomy. CETSA® facilitates label free screening in disease relevant cells while approaching the ease of biochemical assays. In an isothermal setup, full assay plates are heated to a setpoint within the target protein melting curve. While most proteins unfold and precipitate upon this heat-shock, a characteristic of protein-ligand interaction is induced thermal stability. The remaining stabilized protein can subsequently be detected with a pair of anti-species antibodies in an AlphaScreen® system. This high throughput (HT) CETSA® format allows large numbers of compounds to be tested in an HTS setting. Here, we report the development of two CETSA®-HT assays along with the application of this technology in HTS for the first time. This has been enabled following the recent agreement between Pelago Bioscience and PerkinElmer to streamline CETSA®-HT into validated kits and to offer support in the assay development. In the Global High Throughput Screening Centre of AstraZeneca we are exploring the potential and the feasibility of CETSA®-HT for large scale HTS campaigns ( >0.5M compounds). These datasets provide an indication of the future impact CETSA®-HT will have in hit identification. This is particularly timely given the expanding interest across drug discovery groups in new target protein classes. With new modalities like PROTACS (proteolysis targeting chimera) non-catalytically active proteins can now therapeutically be targeted. Utilising CETSA®-HT to identify target engagement in cellular environments early during primary screening could shift the paradigm of hit finding.", "domain": "chemistry", "round": 3} +{"url": "https://www.ars.usda.gov/research/publications/publication/?seqNo115=206912", "date": "2023-09-22T09:56:53Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233506339.10/warc/CC-MAIN-20230922070214-20230922100214-00631.warc.gz", "language_score": 0.9250051379203796, "token_count": 631, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__203570737", "lang": "en", "text": "Submitted to: ASABE Annual International Meeting\nPublication Type: Proceedings\nPublication Acceptance Date: 2/6/2007\nPublication Date: 9/7/2007\nCitation: Lovanh, N.C., Loughrin, J.H., Cook, K.L., Rothrock Jr, M.J., Sistani, K.R. 2007. Effect of Stratification on the Profile of an Anaerobic Swine Waste Treatment Lagoon in Kentucky: A Case Study for Designing Alternative Remediation Options.. ASABE Annual International Meeting.\nTechnical Abstract: An understanding of the nature of wastes in an anaerobic swine lagoon is essential in the design and operation of alternative collection, treatment, and disposal facilities for environmental quality management such as odor control, nutrient and pathogen reduction. In this study, the characterization of an anaerobic swine waste treatment lagoon (0.40 ha) from a farrowing operation (~2000 sows) was carried out to examine the dynamics of the system due to stratification and seasonal variability. Swine waste samples were taken from an anaerobic swine lagoon at different depths (0, 50, 150, and 250 cm) with a pulley system equipped with a special sampler that allows for sampling exclusively at certain depth. The sampling process was carried out from spring to fall season. The pH and temperature were monitored and recorded continuously from the epilimnion (top) and hypolimnion (bottom) layers of the lagoon. The samples were then analyzed for their mineral contents by using Inductively Coupled Plasma (ICP), Total Nitrogen, and Total Organic Carbon analyzers. Microbial dynamics were monitored by DNA extraction and Denaturing Gradient Gel Electrophoresis (DGGE). Preliminary results showed that nutrient (C, N, P, S) concentrations varied according to stratified lagoon layers and season. For example, total organic carbon concentrations range from 1800 mg/L (top) to 5400 mg/L (bottom) for late spring, and from 1100 mg/L (top) to 3600 mg/L (bottom) for the middle of summer. Trace minerals such as Al, Ca, Fe, K, Na, and Mg, on the other hand, appeared to be affected more by stratification than seasonal variability. The reason for the decrease in nutrient concentrations in summer time may be due to increase microbial activities which required more essential nutrients (i.e., C, N, P, S) rather than trace minerals for growth during active season. DGGE analysis also showed that microbial community structure appeared to be affected by the stratification and seasonal variability. There were distinct banding patterns for samples obtained from the epilimnion and hypolimnion. Based on these data, it is important to consider the effect of stratification and seasonal variability of waste loading from traditional anaerobic swine lagoon when designing and operating an alternative anaerobic digester.", "domain": "chemistry", "round": 3} +{"url": "https://www.nhbs.com/bacterial-metabolism-book", "date": "2018-04-27T04:30:43Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-17/segments/1524125949036.99/warc/CC-MAIN-20180427041028-20180427061028-00429.warc.gz", "language_score": 0.8092545866966248, "token_count": 253, "dump": "CC-MAIN-2018-17", "global_id": "webtext-fineweb__CC-MAIN-2018-17__0__231344693", "lang": "en", "text": "+44 1803 865913\nBy: Gerhard Gottschalk\n359 pages, Figs\nExamines pathways used by bacteria for the degradation of organic compounds, the synthesis of cellular consituents, the regulation of bacterial metabolism and the fixation of molecular nitrogen.\nNutrition of Bacteria * How Escherichia coli Synthesizes ATP During Aerobic Growth on Glucose * Biosynthesis of Escherichia coli Cells from Glucose * Aerobic Growth of Escherichia coli on Substrates Other than Glucose * Metabolic Diversity of Aerobic Heterotrophs * Catabolic Activities of Aerobic Heterotrophs * Regulation of Bacterial Metabolism * Bacterial Fermentations * Chemolithotrophic and Phototrophic Metabolism * Fixation of Molecular Nitrogen\nThere are currently no reviews for this product. Be the first to review this product!\nYour orders support book donation projects\nI would not hesitate for one second to use your company again and recommend you to others. Marks out of 10? Around 99!\nSearch and browse over 110,000 wildlife and science products\nMulti-currency. Secure worldwide shipping\nWildlife, science and conservation since 1985", "domain": "chemistry", "round": 3} +{"url": "http://www.mdpi.com/1420-3049/21/12/1738", "date": "2018-02-19T08:22:53Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-09/segments/1518891812556.20/warc/CC-MAIN-20180219072328-20180219092328-00142.warc.gz", "language_score": 0.7411529421806335, "token_count": 356, "dump": "CC-MAIN-2018-09", "global_id": "webtext-fineweb__CC-MAIN-2018-09__0__61123530", "lang": "en", "text": "Safe Synthesis of Alkylhydroxy and Alkylamino Nitramines\nAbstractThree different protocols for the syntheses of hydroxyalkylnitramines are presented and compared. Safety issues regarding the synthesis of nitramines are also discussed. View Full-Text\n- Supplementary File 1:\nSupplementary (PDF, 1617 KB)\nScifeed alert for new publicationsNever miss any articles matching your research from any publisher\n- Get alerts for new papers matching your research\n- Find out the new papers from selected authors\n- Updated daily for 49'000+ journals and 6000+ publishers\n- Define your Scifeed now\nAntonsen, S.; Aursnes, M.; Gallantree-Smith, H.; Dye, C.; Stenstrøm, Y. Safe Synthesis of Alkylhydroxy and Alkylamino Nitramines. Molecules 2016, 21, 1738.\nAntonsen S, Aursnes M, Gallantree-Smith H, Dye C, Stenstrøm Y. Safe Synthesis of Alkylhydroxy and Alkylamino Nitramines. Molecules. 2016; 21(12):1738.Chicago/Turabian Style\nAntonsen, Simen; Aursnes, Marius; Gallantree-Smith, Harrison; Dye, Christian; Stenstrøm, Yngve. 2016. \"Safe Synthesis of Alkylhydroxy and Alkylamino Nitramines.\" Molecules 21, no. 12: 1738.\nNote that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.", "domain": "chemistry", "round": 3} +{"url": "https://keele-repository.worktribe.com/output/407747", "date": "2024-02-28T19:31:46Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707947474744.31/warc/CC-MAIN-20240228175828-20240228205828-00271.warc.gz", "language_score": 0.8915436863899231, "token_count": 333, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__108222849", "lang": "en", "text": "Ionic messengers signal several critical events in carcinogenesis, including metastasis, the leading cause of patient mortality. The aberrant metabolic, proliferative and anti-apoptotic nature of neoplastic cells can be traced to the abnormal expression of their ion transporters and related signalling networks. In this manuscript, we discuss Na(+)/H(+)flux, as mediated by the sodium-hydrogen exchanger isoform 1 (NHE1), a major ion transporter involved in tumourigenesis. Allosteric activation of NHE1 by external stimuli is controlled by phosphorylation of key amino acids on its cytosolic C-terminal tail, which also acts as a signal scaffold for its regulation by intracellular protein and lipid binding partners. In breast cancer cells, pH homeostasis and proton dynamics are disrupted early in transformation. This constitutively activates NHE1, causing a reversal of the plasma membrane pH gradient, resulting in a more alkaline intracellular pH and a more acidic extracellular pH. NHE1-mediated cellular alkalinization potentiates cytoskeletal remodelling, mobilizing cells for directed migration. Concomitant redistribution of NHE1 to invadopodia, where increased proton extrusion promotes proteolytic digestion of the extracellular matrix, primes cells for invasion into the bloodstream. NHE1 hyperactivity therefore heralds an important stage in cancer cell development, critically facilitating the acquisition of the invasive phenotype necessary for metastasis to occur. The potential for targeting NHE1 in the development of novel chemotherapeutic applications is explored.", "domain": "chemistry", "round": 3} +{"url": "http://ecocyc.org/ECOLI/NEW-IMAGE?type=ENZYME&object=EG11101-MONOMER", "date": "2015-10-13T07:27:51Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2015-40/segments/1443737994631.83/warc/CC-MAIN-20151001221954-00219-ip-10-137-6-227.ec2.internal.warc.gz", "language_score": 0.6570197939872742, "token_count": 3110, "dump": "CC-MAIN-2015-40", "global_id": "webtext-fineweb__CC-MAIN-2015-40__0__118154983", "lang": "en", "text": "|Gene:||aes||Accession Numbers: EG11101 (EcoCyc), b0476, ECK0470|\nAes catalyzes hydrolysis of p-nitrophenyl esters of fatty acids, preferring substrates with short (<8 in length) acyl chains [Kanaya98]. Aes binds to the maltose operon regulator, MalT, and inhibits MalT transcriptional activation activity in competition with its inducer, maltotriose [Joly02]. Residues in MalT that are important for binding of Aes have been identified [Schlegel02], and structure-based alanine scanning mutagenesis has identified residues in Aes that are responsible for interaction with MalT [Schiefner13]. Aes also binds to α-galactosidase; this interaction stimulates Aes esterase activity and inhibits α-galactosidase, suggesting that Aes may have a physiological role in regulation of metabolism of carbohydrates [Mandrich02]. Other proteins that interact with Aes have been identified [DAmbrosio08].\nAes has similarity to lipases and esterases [Peist97] and belongs to the hormone-sensitive lipase (HSL) protein family [Kanaya98]. The enzyme may be either monomeric [Kanaya98] or homodimeric [Schiefner13]; it has been crystallized [Sorrentino03, Gerber04], and crystal structures have been solved [Schiefner13]. Denaturant-induced unfolding of the enzyme has been studied [Del04], and a mutant with higher thermostability has been isolated [Farias07]. The catalytic triad was predicted to comprise Ser165, Asp262, and His292 [Kanaya98]; site-directed mutagenesis confirmed that these residues are required for catalytic activity. In addition, Asp164 is thought to be structurally important [Haruki99]. Point mutations in L97 and L209 increase enzymatic activity by increasing kcat and decreasing Km, respectively [Kobayashi12].\nOverexpression of aes results in increased p-nitrophenyl acetate hydrolysis, compared to wild type, and this strain shows growth on triacetyl glycerol and repression of the maltose transport system [Peist97]. A genetic interaction between malT and aes has been observed [Peist97]. Mutations in MalT have differential effects on the sensitivity of MalT to Aes and MalY, which inhibit the activator in similar, yet distinct, ways [Joly02, Schlegel02].\nAes is identical to esterase B, a protein marker used to distinguish E. coli phylogenetic groups [Lescat09].\nAes: \"acetyl esterase\" [Peist97]\n|Map Position: [498,238 <- 499,197] (10.74 centisomes, 39°)||Length: 960 bp / 319 aa|\nMolecular Weight of Polypeptide: 36.034 kD (from nucleotide sequence), 37.0 kD (experimental) [Peist97 ]\nUnification Links: ASAP:ABE-0001651 , DIP:DIP-9062N , EchoBASE:EB1093 , EcoGene:EG11101 , EcoliWiki:b0476 , ModBase:P23872 , OU-Microarray:b0476 , PortEco:aes , PR:PRO_000022064 , Protein Model Portal:P23872 , RefSeq:NP_415009 , RegulonDB:EG11101 , SMR:P23872 , String:511145.b0476 , UniProt:P23872\nRelationship Links: InterPro:IN-FAMILY:IPR002168 , InterPro:IN-FAMILY:IPR013094 , InterPro:IN-FAMILY:IPR023508 , InterPro:IN-FAMILY:IPR029058 , PDB:Structure:4KRX , PDB:Structure:4KRY , Pfam:IN-FAMILY:PF07859 , Prosite:IN-FAMILY:PS01173 , Prosite:IN-FAMILY:PS01174\n|Biological Process:||GO:0043433 - negative regulation of sequence-specific DNA binding transcription factor activity\nGO:0051346 - negative regulation of hydrolase activity [Mandrich02]\nGO:0008152 - metabolic process [GOA01]\n|Molecular Function:||GO:0005515 - protein binding\nGO:0008126 - acetylesterase activity [Kanaya98]\nGO:0016787 - hydrolase activity [UniProtGOA11, GOA01, Kanaya98]\nGO:0034338 - short-chain carboxylesterase activity [Kanaya98]\nGO:0042803 - protein homodimerization activity [Schiefner13]\nGO:0052689 - carboxylic ester hydrolase activity [UniProtGOA11, GOA06, GOA01]\n|Cellular Component:||GO:0005737 - cytoplasm\n[UniProtGOA11a, UniProtGOA11, GOA06, GOA01, Kanaya98]\nGO:0005829 - cytosol [DiazMejia09]\n|MultiFun Terms:||metabolism → carbon utilization → carbon compounds|\n|Growth Medium||Growth?||T (°C)||O2||pH||Osm/L||Growth Observations|\n|LB enriched||Yes||37||Aerobic||6.95||Yes [Gerdes03, Comment 1]|\n|LB Lennox||Yes||37||Aerobic||7||Yes [Baba06, Comment 2]|\n|M9 medium with 1% glycerol||Yes||37||Aerobic||7.2||0.35||Yes [Joyce06, Comment 3]|\n|MOPS medium with 0.4% glucose||Yes||37||Aerobic||7.2||0.22||Yes [Baba06, Comment 2]|\nEnzymatic reaction of: acetyl esterase\nSynonyms: acetyl-esterase, acetylesterase\nEC Number: 220.127.116.11\nThe reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.\nThe reaction is physiologically favored in the direction shown.\nKinetic parameters for various p-nitrophenyl esters of fatty acids have been measured [Kanaya98].\nNote that acetyl-esterase is unstable at its optimal temperature [Farias07].\nT(opt): 65 °C [Farias07]\n|Protein-Segment||91 -> 93|\n|Sequence-Conflict||275 -> 319|\n10/20/97 Gene b0476 from Blattner lab Genbank (v. M52) entry merged into EcoCyc gene EG11101; confirmed by SwissProt match.\nBaba06: Baba T, Ara T, Hasegawa M, Takai Y, Okumura Y, Baba M, Datsenko KA, Tomita M, Wanner BL, Mori H (2006). \"Construction of Escherichia coli K-12 in-frame, single-gene knockout mutants: the Keio collection.\" Mol Syst Biol 2;2006.0008. PMID: 16738554\nDAmbrosio08: D'Ambrosio C, Mandrich L, Rossi M, Scaloni A, Manco G (2008). \"A proteomic approach to study Escherichia coli. Acetyl esterase interactors unveil a sequence motif involved in protein-protein interaction.\" Protein Pept Lett 15(4);333-40. PMID: 18473943\nDel03: Del Vecchio P, Graziano G, Granata V, Barone G, Mandrich L, Rossi M, Manco G (2003). \"Effect of trifluoroethanol on the conformational stability of a hyperthermophilic esterase: a CD study.\" Biophys Chem 104(2);407-15. PMID: 12878309\nDel04: Del Vecchio P, Graziano G, Granata V, Farias T, Barone G, Mandrich L, Rossi M, Manco G (2004). \"Denaturant-induced unfolding of the acetyl-esterase from Escherichia coli.\" Biochemistry 43(46);14637-43. PMID: 15544334\nDiazMejia09: Diaz-Mejia JJ, Babu M, Emili A (2009). \"Computational and experimental approaches to chart the Escherichia coli cell-envelope-associated proteome and interactome.\" FEMS Microbiol Rev 33(1);66-97. PMID: 19054114\nGerber04: Gerber K, Schiefner A, Seige P, Diederichs K, Boos W, Welte W (2004). \"Crystallization and preliminary X-ray analysis of Aes, an acetyl-esterase from Escherichia coli.\" Acta Crystallogr D Biol Crystallogr 60(Pt 3);531-3. PMID: 14993683\nGerdes03: Gerdes SY, Scholle MD, Campbell JW, Balazsi G, Ravasz E, Daugherty MD, Somera AL, Kyrpides NC, Anderson I, Gelfand MS, Bhattacharya A, Kapatral V, D'Souza M, Baev MV, Grechkin Y, Mseeh F, Fonstein MY, Overbeek R, Barabasi AL, Oltvai ZN, Osterman AL (2003). \"Experimental determination and system level analysis of essential genes in Escherichia coli MG1655.\" J Bacteriol 185(19);5673-84. PMID: 13129938\nHaruki99: Haruki M, Oohashi Y, Mizuguchi S, Matsuo Y, Morikawa M, Kanaya S (1999). \"Identification of catalytically essential residues in Escherichia coli esterase by site-directed mutagenesis.\" FEBS Lett 454(3);262-6. PMID: 10431819\nJoly02: Joly N, Danot O, Schlegel A, Boos W, Richet E (2002). \"The Aes protein directly controls the activity of MalT, the central transcriptional activator of the Escherichia coli maltose regulon.\" J Biol Chem 277(19);16606-13. PMID: 11867639\nJoyce06: Joyce AR, Reed JL, White A, Edwards R, Osterman A, Baba T, Mori H, Lesely SA, Palsson BO, Agarwalla S (2006). \"Experimental and computational assessment of conditionally essential genes in Escherichia coli.\" J Bacteriol 188(23);8259-71. PMID: 17012394\nKhersonsky11: Khersonsky O, Malitsky S, Rogachev I, Tawfik DS (2011). \"Role of chemistry versus substrate binding in recruiting promiscuous enzyme functions.\" Biochemistry 50(13);2683-90. PMID: 21332126\nKobayashi12: Kobayashi R, Hirano N, Kanaya S, Haruki M (2012). \"Enhancement of the enzymatic activity of Escherichia coli acetyl esterase by a double mutation obtained by random mutagenesis.\" Biosci Biotechnol Biochem 76(11);2082-8. PMID: 23132590\nLescat09: Lescat M, Hoede C, Clermont O, Garry L, Darlu P, Tuffery P, Denamur E, Picard B (2009). \"aes, the gene encoding the esterase B in Escherichia coli, is a powerful phylogenetic marker of the species.\" BMC Microbiol 9;273. PMID: 20040078\nMandrich02: Mandrich L, Caputo E, Martin BM, Rossi M, Manco G (2002). \"The Aes protein and the monomeric alpha-galactosidase from Escherichia coli form a non-covalent complex. Implications for the regulation of carbohydrate metabolism.\" J Biol Chem 277(50);48241-7. PMID: 12374803\nMiyamoto91: Miyamoto K, Nakahigashi K, Nishimura K, Inokuchi H (1991). \"Isolation and characterization of visible light-sensitive mutants of Escherichia coli K12.\" J Mol Biol 219(3);393-8. PMID: 2051480\nPeist97: Peist R, Koch A, Bolek P, Sewitz S, Kolbus T, Boos W (1997). \"Characterization of the aes gene of Escherichia coli encoding an enzyme with esterase activity.\" J Bacteriol 179(24);7679-86. PMID: 9401025\nSchlegel02: Schlegel A, Danot O, Richet E, Ferenci T, Boos W (2002). \"The N terminus of the Escherichia coli transcription activator MalT is the domain of interaction with MalY.\" J Bacteriol 184(11);3069-77. PMID: 12003949\nSorrentino03: Sorrentino N, De Simone G, Menchise V, Mandrich L, Rossi M, Manco G, Pedone C (2003). \"Crystallization and preliminary X-ray diffraction studies of Aes acetyl-esterase from Escherichia coli.\" Acta Crystallogr D Biol Crystallogr 59(Pt 10);1846-8. PMID: 14501134\n©2015 SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025-3493", "domain": "chemistry", "round": 3} +{"url": "https://pubmed.ncbi.nlm.nih.gov/28911206/", "date": "2021-12-02T11:22:13Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-49/segments/1637964361253.38/warc/CC-MAIN-20211202084644-20211202114644-00006.warc.gz", "language_score": 0.8941541314125061, "token_count": 419, "dump": "CC-MAIN-2021-49", "global_id": "webtext-fineweb__CC-MAIN-2021-49__0__2021365", "lang": "en", "text": "Congenital hyperinsulinism/hyperammonemia (HI/HA) syndrome gives rise to unregulated protein-induced insulin secretion from pancreatic beta-cells, fasting hypoglycemia and elevated plasma ammonia levels. Mutations associated with HI/HA were identified in the Glud1 gene, encoding for glutamate dehydrogenase (GDH). We aimed at identifying the molecular causes of dysregulation in insulin secretion and ammonia production conferred by the most frequent HI/HA mutation Ser445Leu. Following transduction with adenoviruses carrying the human GDH-wild type or GDH-S445L-mutant gene, immunoblotting showed efficient expression of the transgenes in all the investigated cell types. Enzymatic activity tested in INS-1E beta-cells revealed that the mutant was much more sensitive to the allosteric activator ADP, rendering it highly responsive to substrates. INS-1E cells expressing either the wild type or mutant GDH responded similarly to glucose stimulation regarding mitochondrial activation and insulin secretion. However, at basal glucose glutamine stimulation increased mitochondrial activity and insulin release only in the mutant cells. In mouse and human islets, expression of mutant GDH resulted in robust elevation of insulin secretion upon glutamine stimulation, not observed in control islets. Hepatocytes expressing either the wild type or mutant GDH produced similar levels of ammonia when exposed to glutamine, although alanine response was strongly elevated with the mutant form. In conclusion, the GDH-S445L mutation confers hyperactivity to this enzyme due to higher sensitivity to ADP allosteric activation. This renders beta-cells responsive to amino acid stimulation, explaining protein-induced hypoglycemia secondary to non-physiological insulin release. Hepatocytes carrying mutant GDH produced more ammonia upon alanine exposure, which underscores hyperammonemia developed by the patients.\n© The Author 2017. Published by Oxford University Press. All rights reserved. For Permissions, please email: firstname.lastname@example.org.", "domain": "chemistry", "round": 3} +{"url": "https://www.kernow-oils.co.uk/products/castrol-transmax-dx-iii-multi/", "date": "2024-04-21T10:56:27Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712296817765.59/warc/CC-MAIN-20240421101951-20240421131951-00442.warc.gz", "language_score": 0.7919864654541016, "token_count": 601, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__139955399", "lang": "en", "text": "Castrol Transmax ATF DX III Multivehicle\nVISCOSITY - ISO 35\nCastrol Transmax ATF DX III Multivehicle Automatic Transmission Fluid\nCastrol Transmax DX III Multivehicle is designed for use in GM automatic transmissions pre-2005 and Ford automatic transmissions built between 1983 and 1996 where Dexron® (II or III) or Mercon are required. This product is approved for use in Allison heavy-duty transmissions against TES 389.\nIt is also approved for use in a wide range of European heavy-duty automatic transmissions. It may be used in some power steering units.\nNB: Do not use where MERCON® V,\nMERCON® SP or DEXRON® VI is required.\nCastrol Transmax ATF DX III Multivehicle Automatic Transmission Fluid Product Advantages:\n- Multiple manufacturer approvals make it suitable for wide-ranging use.\n- It is specifically formulated for high thermal stability and resistance to oxidation which protects against the\nformation of deposits and oil thickening prolonging the life of components and lubricant.\n- Optimised friction characteristics provide smooth shifting and efficient power transfer.\n- A high viscosity index provides a stable viscosity over a wide temperature range for effective protection of\ntransmissions and operation of power steering units\n|Transmax Dex III Multivehicle\n|Density @ 15C, Relative\n|Viscosity, Kinematic 100C\n|Viscosity, Kinematic 40C\n|Viscosity, Brookfield @ -40C\n|Flash Point, COC\nAllison TES 389\nZF TE-ML 04D, 14A\nMAN 339 Typ Z1\nMAN 339 Typ V1\nMAN 339 Typ L1\nVolvo Transmission Oil 97341\nMeets Mercon®, Dexron® IIIH, Volvo Transmission Oil 97340\nAll packages should be stored under cover. Where outside storage is unavoidable drums should be laid horizontally to avoid the possible ingress of water and damage to drum markings. Products should not be stored above 60°C, or exposed to hot sun or freezing conditions.", "domain": "chemistry", "round": 3} +{"url": "https://protoolscebu.co/collections/mom-baby/products/coppertone-waterbabies-sunscreen-lotion-spf-50237ml", "date": "2022-08-12T05:15:35Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571584.72/warc/CC-MAIN-20220812045352-20220812075352-00707.warc.gz", "language_score": 0.7549915313720703, "token_count": 456, "dump": "CC-MAIN-2022-33", "global_id": "webtext-fineweb__CC-MAIN-2022-33__0__192553408", "lang": "en", "text": "Coppertone WaterBabies Sunscreen Lotion SPF 50(237ml)\nOut of stock\n- Hypoallergenic & Gentle\n- #1 Pediatrician Recommended Brand\n- No Dyes, PABA, Oxybenzone\n- Water Resistant (80 Minutes)\n- Broad Spectrum SPF 50\n- Helps prevent sunburn\n- If used as directed with other sun protection measures (see Directions)\n- After 80 minutes of swimming or sweating\n- Immediately after towel drying\n- At least every 2 hours\n- Regularly use a sunscreen with a Broad Spectrum SPF value of 15 or higher and other sun protection measures including:\n- Limit time in the sun, especially from 10 am-2 pm.\n- Wear long-sleeved shirts, pants, hats and sunglasses.\n- Children under 6 months: Ask a doctor.\n|Avobenzone 3%, Homosalate 9%, Octisalate 4.5%, Octocrylene 9%||Sunscreen|\nWater, aloe barbadensis leaf juice, C12-15 alkyl benzoate, neopentyl glycol diheptanoate, styrene/acrylates copolymer, butylene glycol, VP/Eicosene copolymer, 1,2-Hexanediol, hydroxyacetophenone, fragrance, tocopherol, acrylates/C10-30 alkyl acrylate crosspolymer, potassium hydroxide, disodium EDTA, sodium ascorbyl phosphate\nDo not use on damaged or broken skin.\nWhen using this product, keep out of eyes. Rinse with water to remove.\nStop use and ask a doctor if rash occurs.\nKeep out of reach of children. If product is swallowed, get medical help or contact a Poison Control Center right away.\nProtect this product from excessive heat and direct sun.\nMay stain or damage some fabrics or surfaces.", "domain": "chemistry", "round": 3} +{"url": "https://www.iasp-pain.org/publications/pain-research-forum/papers-of-the-week/paper/bispecific-sigma-1-receptor-antagonism-and-mu-opioid-receptor-partial-agonism-wlb-73502-an-analgesic-with-improved-efficacy-and-safety-profile-compared-to-strong-opioids/", "date": "2023-04-01T20:16:02Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-14/segments/1679296950247.65/warc/CC-MAIN-20230401191131-20230401221131-00644.warc.gz", "language_score": 0.9121708273887634, "token_count": 321, "dump": "CC-MAIN-2023-14", "global_id": "webtext-fineweb__CC-MAIN-2023-14__0__185534930", "lang": "en", "text": "Opioids are the most effective painkillers, but their benefit-risk balance often hinder their therapeutic use. WLB-73502 is a dual, bispecific compound that binds sigma-1 (S1R) and mu-opioid (MOR) receptors. WLB-73502 is an antagonist at the S1R. It behaved as a partial MOR agonist at the G-protein pathway and produced no/unsignificant -arrestin-2 recruitment, thus demonstrating low intrinsic efficacy on MOR at both signalling pathways. Despite its partial MOR agonism, WLB-73502 exerted full antinociceptive efficacy, with potency superior to morphine and similar to oxycodone against nociceptive, inflammatory and osteoarthritis pain, and superior to both morphine and oxycodone against neuropathic pain. WLB-73502 crosses the blood-brain barrier and binds brain S1R and MOR to an extent consistent with its antinociceptive effect. Contrary to morphine and oxycodone, tolerance to its antinociceptive effect did not develop after repeated 4-week administration. Also, contrary to opioid comparators, WLB-73502 did not inhibit gastrointestinal transit or respiratory function in rats at doses inducing full efficacy, and it was devoid of proemetic effect (retching and vomiting) in ferrets at potentially effective doses. WLB-73502 benefits from its bivalent S1R antagonist and partial MOR agonist nature to provide an improved antinociceptive and safety profile respect to strong opioid therapy.", "domain": "chemistry", "round": 3} +{"url": "https://www.hydrodipprint.com/2022/11/28/fully-introduction-of-hydro-dipping-activator/", "date": "2023-03-27T23:23:18Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-14/segments/1679296948708.2/warc/CC-MAIN-20230327220742-20230328010742-00423.warc.gz", "language_score": 0.9237586855888367, "token_count": 1646, "dump": "CC-MAIN-2023-14", "global_id": "webtext-fineweb__CC-MAIN-2023-14__0__282498241", "lang": "en", "text": "Hydro dipping is the process of applying a hydrographic film to an object to give it a three-dimensional, textured finish. hydro dipping activator is used to prep the surface of the object to be dipped, as well as to activate the hydro graphic film. hydro dipping activator can be applied with a brush or sprayer. A hydro dipping activator is a necessary step in hydro dipping, and should be done before any other hydro graphics steps are taken. hydro dipping activator will ensure that the hydrographic film adheres properly to the object, and will create a strong bond between the two surfaces. hydro dipping activator is available in both water-based and solvent-based formulas. once the hydro dipping activator has been applied, it is time to apply the hydro graphic film.\n1. What is a Hydro dipping activator\nHydro dipping activator is a chemical agent used to improve the adhesion of coatings to substrates.\nHydro dipping is a process of printing designs on three-dimensional objects. The object to be printed is first dipped in a vat of water, which acts as a transfer medium.\nThen, the object is dipped into a vat of paint, which adheres to the water on the surface of the object.\nFinally, the object is removed from the paint and allowed to dry, resulting in a unique and eye-catching design.\nHydro dipping activator is a substance that is added to the water in order to improve the adhesion of the paint to the surface of the object.\nActivators can be either commercially available products or homemade solutions, such as vinegar or detergent.\nIn addition to improving the adhesion of the paint, activators can also help to prevent air bubbles from forming on the surface of the object during the printing process.\n2. Benefits of hydro dipping activator\nIt is an important step in the hydro dipping process and helps to ensure that the coating will not peel or chip off over time.\nSupply hydro dipping activator is an important step in the hydro dipping process and helps to ensure that the coating will not peel or chip off over time. By prepping the surface with a primer, you help to create a smooth foundation for the paint to adhere to. In addition, activator helps to harden the paint, making it more resistant to wear and tear. As a result, supply hydro dipping activator is an essential product if you want your hydro dipped item to last for years to come.\nHydro dipping is a popular technique for applying decorative finishes to a variety of objects, from car parts to gaming controllers. The process involves submerging the object in a vat of water, which is then coated with a layer of film. Once the film has been applied, it is then cured using ultraviolet light or heat.\nOne of the most important steps in the hydro-dipping process is properly applying the hydro-dipping activator on the surface of the hydro-dipping film. This step helps to ensure that the hydro dipping graphic design will leave the based film, getting adhesive when dissolving and flowing on the water. And also the hydrographic activator will remove the air bubble during the dissolving of the hydrographic film design.\nAfter spraying hydro dipped activator, you can start to do following hydro-dipping steps:\nFirst, the surface must be cleaned of any dirt, dust, or grease.\nNext, it should be sanded smooth to provide a good foundation for the film.\nOnce the surface has been prepared, hydro dipping can begin.\nBy following these simple steps, you can ensure that your hydro dipped finish will last for years to come.\nWhy hydro dipping activator doesn’t work, how to Adjust it?\nHydro dipping is a process of applying a design to an object by dipping it into a vat of water that has been treated with a special activator. The activator reacts with the object to create a bond that allows the design to be transferred.\nHydro dipping is often used to apply designs to car parts, but it can also be used on other objects such as cups, phone cases, and even gaming controllers.\nThe advantage of hydro dipping is that it allows for a very precise and detailed design to be applied to an object. This can be helpful if you want to create a one-of-a-kind look for your car or if you want to apply a design that is not possible with other methods.\nHydro dipping activator is available in different recipes according to the different designs of hydrographic film, so you can match the material and the design of the hydrographic dipping film to adjust your recipes of the activator. This can help you achieve a more professional look for your car or object.\nWhen selecting an activator, be sure to choose one that is compatible with the type of object you are hydro dipping. If you are unsure, consult with a professional before beginning your project.\n3. Tips for spraying hydro dipping activator\nThe hydro-dipping activator is an important step in hydro-dipping process. If you spray the activator in a wrong way, you can not get the good final look. For this step, the car painting staff will be superior to other people, they always can do it well.\nIf you are starter, please keep mentions in the following when you spraying the hydro dip activator.\nYou need to leave enough time to wait for the hydro-dipping film to get wet and dissolve in the water. Then spray the hydrographic activator. Wait for 90-120 seconds for the hydrographic film’s dissolution.\nAdjust the spray gun right, to ensure the activator fog is evenly sprayed.\nSpray the hydro-dipping activator at the right volume.\nThe right spraying volume of the hydro-dipping activator is very important to the hydro-dipping process. Too much hydrographic activator or less volume of activator will cause a dipping problem, making you hydro dipping failure.\nActivator Problem & Solution\n1. The pattern will flow\nReason: The activator is sprayed too much\nSolution: To reduce the amount of activator spray\n2. The pattern part is not attached or printed not completely.\nReason: It can be caused by three situations\n1> The activator is unevenly coated\n2> The air temperature and water temperature are too high\n3> The activator evaporates quickly\n1> Spray the activator evenly\n2> Lower the air temperature and water temperature\n3> Spray the activator evenly by adjusting the spray gun etc.\n3. Occurs Blisters on the surface\nReason: This situation will happen for two reasons.\n1> The activator is sprayed too less.\n2> The entering angle is wrong when putting the pre-dip item into the water through hydrographic film.\n1> Spray enough activator on the hydro dip film.\n2> Adjust the entering angle when putting the pre-dip product through the hydro-dip film.\nSummary of hydro dipping activator\nHydro dipping activator is a water-based solution that helps to adhere hydro dip film to the surface of an object.\nThe hydro-dipping process involves dipping an object into a tank of water and then applying a hydro dipped film to the surface.\nThe hydro dipped film will then float on the surface of the water and can be applied to the object using a variety of methods.\nHydro dipping activator helps to ensure that the hydro dipped film adheres properly to the surface of the object, creating a smooth and even finish.\nIt is important to note that hydro dipping activator is not a adhesive and should not be used in place of adhesive when applying hydro dip film. Hydro dipping activator should only be used when hydro dipping; it is not necessary for other types of applications.", "domain": "chemistry", "round": 3} +{"url": "https://www.huabio.com/products/cyclin-h-antibody-clone-sn20-48-recombinant-monoclonal-et1611-84", "date": "2021-09-24T15:52:12Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-39/segments/1631780057558.23/warc/CC-MAIN-20210924140738-20210924170738-00215.warc.gz", "language_score": 0.7879872918128967, "token_count": 541, "dump": "CC-MAIN-2021-39", "global_id": "webtext-fineweb__CC-MAIN-2021-39__0__59489220", "lang": "en", "text": "Recombinant Rabbit monoclonal primary\nCyclin H Recombinant Rabbit Monoclonal Antibody [SN20-48] (ET1611-84)\nRecombinant protein within human cyclin h aa 230-323 / 323.\nK562, MCF-7, Hela, PC-3M, human colon cancer tissue, mouse testis tissue.\nStore at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.\n1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.\nProtein A purified.\n6330408H09Rik antibody; AI661354 antibody; AV102684 antibody; AW538719 antibody; CAK antibody; CAK complex subunit antibody; ccnh antibody; CCNH_HUMAN antibody; CDK activating kinase antibody; CDK activating kinase complex subunit antibody; Cyclin dependent kinase activating kinase antibody; cyclin dependent kinase activating kinase complex subunit antibody; Cyclin H antibody; Cyclin-H antibody; CyclinH antibody; MO15 associated protein antibody; MO15-associated protein antibody; p34 antibody; p36 antibody; p37 antibody\nBelongs to the cyclin family. Cyclin C subfamily.\nProgression through the cell cycle requires activation of a series of enzymes designated cyclin dependent kinases (Cdks). The monomeric catalytic subunit, Cdk2, a critical enzyme for initiation of cell cycle progression, is completely inactive. Partial activation is achieved by the binding of regulatory cyclins such as cyclin D1, while full activation requires, in addition, phosphorylation at Thr-160. The enzyme responsible for phosphorylation of Thr-160 in Cdk2 and also Thr-161 in Cdc2 p34, designated Cdk-activating kinase (CAK), has been partially purified and shown to be comprised of a catalytic subunit and a regulatory subunit. The catalytic subunit, designated Cdk7, has been identified as the mammalian homolog of MO15, a protein kinase demonstrated earlier in starfish and Xenopus. The regulatory subunit is a novel cyclin (cyclin H) and is required for activation of Cdk7. Like other Cdks, Cdk7 contains a conserved threonine required for full activity; mutation of this residue severely reduces CAK activity.", "domain": "chemistry", "round": 3} +{"url": "https://pubmed.ncbi.nlm.nih.gov/35660157/", "date": "2023-02-03T14:48:53Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-06/segments/1674764500056.55/warc/CC-MAIN-20230203122526-20230203152526-00774.warc.gz", "language_score": 0.8641353845596313, "token_count": 251, "dump": "CC-MAIN-2023-06", "global_id": "webtext-fineweb__CC-MAIN-2023-06__0__188374675", "lang": "en", "text": "The bacterial peptidoglycan enclosing the cytoplasmic membrane is a fundamental cellular architecture. The integral membrane protein MurJ plays an essential role in flipping the cell wall building block Lipid II across the cytoplasmic membrane for peptidoglycan biosynthesis. Previously reported crystal structures of MurJ have elucidated its V-shaped inward- or outward-facing forms with an internal cavity for substrate binding. MurJ transports Lipid II using its cavity through conformational transitions between these two forms. Here, we report two crystal structures of inward-facing forms from Arsenophonus endosymbiont MurJ and an unprecedented crystal structure of Escherichia coli MurJ in a \"squeezed\" form, which lacks a cavity to accommodate the substrate, mainly because of the increased proximity of transmembrane helices 2 and 8. Subsequent molecular dynamics simulations supported the hypothesis that the squeezed form is an intermediate conformation. This study fills a gap in our understanding of the Lipid II flipping mechanism.\nKeywords: Lipid II flippase; MD simulation; MurJ; X-ray crystallography; membrane protein; transporter.\nCopyright © 2022 Elsevier Ltd. All rights reserved.", "domain": "chemistry", "round": 3} +{"url": "https://rupress.org/jcb/article-standard/32/3/719/16904/THE-SUBMITOCHONDRIAL-LOCALIZATION-OF-MONOAMINE", "date": "2024-04-21T14:55:31Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712296817780.88/warc/CC-MAIN-20240421132819-20240421162819-00092.warc.gz", "language_score": 0.8737007975578308, "token_count": 446, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__147661872", "lang": "en", "text": "Controlled osmotic lysis (water-washing) of rat liver mitochondria results in a mixed population of small vesicles derived mainly from the outer mitochondrial membrane and of larger bodies containing a few cristae derived from the inner membrane. These elements have been separated on Ficoll and sucrose gradients. The small vesicles were rich in monoamine oxidase, and the large bodies were rich in cytochrome oxidase. Separation of the inner and outer membranes has also been accomplished by treating mitochondria with digitonin in an isotonic medium and fractionating the treated mitochondria by differential centrifugation. Treatment with low digitonin concentrations released monoamine oxidase activity from low speed mitochondrial pellets, and this release of enzymatic activity was correlated with the loss of the outer membrane as seen in the electron microscope. The low speed mitochondrial pellet contained most of the cytochrome oxidase and malate dehydrogenase activities of the intact mitochondria, while the monoamine oxidase activity could be recovered in the form of small vesicles by high speed centrifugation of the low speed supernatant. The results indicate that monoamine oxidase is found only in the outer mitochondrial membrane and that cytochrome oxidase is found only in the inner membrane. Digitonin treatment released more monoamine oxidase than cytochrome oxidase from sonic particles, thus indicating that digitonin preferentially degrades the outer mitochondrial membrane.\nTHE SUBMITOCHONDRIAL LOCALIZATION OF MONOAMINE OXIDASE : An Enzymatic Marker for the Outer Membrane of Rat Liver Mitochondria\nCarl Schnaitman, V. Gene Erwin, John W. Greenawalt; THE SUBMITOCHONDRIAL LOCALIZATION OF MONOAMINE OXIDASE : An Enzymatic Marker for the Outer Membrane of Rat Liver Mitochondria . J Cell Biol 1 March 1967; 32 (3): 719–735. doi: https://doi.org/10.1083/jcb.32.3.719\nDownload citation file:", "domain": "chemistry", "round": 3} +{"url": "http://sph.unc.edu/profiles/rebecca-fry/", "date": "2016-02-13T06:51:08Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2016-07/segments/1454701166222.10/warc/CC-MAIN-20160205193926-00016-ip-10-236-182-209.ec2.internal.warc.gz", "language_score": 0.7931917905807495, "token_count": 596, "dump": "CC-MAIN-2016-07", "global_id": "webtext-fineweb__CC-MAIN-2016-07__0__167560609", "lang": "en", "text": "Environmental Sciences & Engineering\n1995 William Smith College BS, Biology\n1997 Tulane University MS, Biology\n2000 Tulane University PhD, Biology\n- Child development\n- Environment (water)\n- Global health\nThe lab focuses on understanding how environmental exposures are associated with human disease with a particular focus on genomic and epigenomic perturbations. Using environmental toxicogenomics and systems biology approaches, we aim to identify key molecular pathways that associate environmental exposure with diseases. A current focus in the lab is to study prenatal exposure to various types of metals including arsenic, cadmium, and lead. We aim to understand molecular mechanisms by which such early exposures are associated with long-term health effects in humans. For example, we are examining DNA methylation profiles in humans exposed to metals during the prenatal period. This research will enable the identification of gene and epigenetic biomarkers of metal exposure. The identified genes can serve as targets for study to unravel potential molecular bases for metal-induced disease. Ultimately, we aim to identify mechanisms of metal -induced disease and the basis for inter-individual disease susceptibility.\nSmeester L, Rager JE, Bailey KA, Guan X, Smith N, García-Vargas G, Del Razo LM, Drobná Z, Kelkar H, Stíyblo M, Fry RC (2011) Epigenetic changes in individuals with arsenicosis. Chemical Research in Toxicology: vol.24(2):165-7\nBenton MA, Rager JE, Smeester L, Fry RC. (2011) Comparative genomic analyses identify common molecular pathways modulated upon exposure to low doses of arsenic and cadmium. BMC Genomics: vol.12, p.2011 Apr 1;12(1):173.\nRager JE, Smeester L, Jaspers I, Sexton KG, Fry RC. (2010) Epigenetic Changes Induced by Air Toxics: Formaldehyde Exposure Alters miRNA Expression Profiles in Human Lung Cells. EHP\nLiu Q, Zhang H, Smeester L, Zou F, Kesic M, Jaspers I, Pi J, Fry RC. (2010) The NRF2-mediated oxidative stress response pathway is associated with tumor cell resistance to arsenic trioxide across the NCI-60 panel. BMC Medical Genomics: vol.3, p.37.\nFry RC, Navasumrit P, Valiathan C, Svensson JP, Hogan BJ, Luo M, Bhattacharya S, Kandjanapa K, Soontararuks S, Nookabkaew S, Mahidol C, Ruchirawat M, Samson LD (2007)\nActivation of inflammation/NF-kappaB signaling in infants born to arsenic-exposed mothers. PLoS Genet.: vol.11, p.e207.", "domain": "chemistry", "round": 3} +{"url": "https://rup.silverchair.com/jcb/article/135/6/1471/29339/Formation-of-nascent-secretory-vesicles-from-the", "date": "2024-03-02T17:40:03Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707947475833.51/warc/CC-MAIN-20240302152131-20240302182131-00735.warc.gz", "language_score": 0.8911751508712769, "token_count": 551, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__26150051", "lang": "en", "text": "Recent evidence suggests that secretory vesicle formation from the TGN is regulated by cytosolic signaling pathways involving small GTP-binding proteins, heterotrimeric G proteins, inositol phospholipid metabolism, and protein serine/threonine phosphorylation. At the cell surface, protein phosphorylation and dephosphorylation on tyrosine residues can rapidly modulate cytosolic signaling pathways in response to extracellular stimuli and have been implicated in the internalization and sorting of signaling receptors. to determine if phosphotyrosine metabolism might also regulate secretory vesicle budding from the TGN, we treated permeabilized rat pituitary GH3 cells with inhibitors of either tyrosine phosphatases or tyrosine kinases. We demonstrate that the tyrosine phosphatase inhibitors pervanadate and zinc potently inhibited budding of nascent secretory vesicles. Tyrphostin A25 (TA25) and other tyrosine kinase inhibitors also prevented secretory vesicle release, suggesting that vesicle formation requires both phosphatase and kinase activities. A stimulatory peptide derived from the NH2 terminus of the small GTP-binding protein ADP ribosylation factor 1 (ARF1) antagonized the inhibitory effect of TA25, indicating that both agents influence the same pathway leading to secretory vesicle formation. Antiphosphotyrosine immunoblotting revealed that protein tyrosine phosphorylation was enhanced after treatment with tyrosine phosphatase or kinase inhibitors. Subcellular fractionation identified several tyrosine phosphorylated polypeptides of approximately 175, approximately 130, and 90-110 kD that were enriched in TGN-containing Golgi fractions and tightly membrane associated. The phosphorylation of these polypeptides correlated with inhibition of vesicle budding. Our results suggest that in endocrine cells, protein tyrosine phosphrylation and dephosphorylation are required for secretory vesicle release from the TGN.\nFormation of nascent secretory vesicles from the trans-Golgi network of endocrine cells is inhibited by tyrosine kinase and phosphatase inhibitors.\nC D Austin, D Shields; Formation of nascent secretory vesicles from the trans-Golgi network of endocrine cells is inhibited by tyrosine kinase and phosphatase inhibitors.. J Cell Biol 15 December 1996; 135 (6): 1471–1483. doi: https://doi.org/10.1083/jcb.135.6.1471\nDownload citation file:", "domain": "chemistry", "round": 3} +{"url": "https://espace.curtin.edu.au/handle/20.500.11937/37263", "date": "2024-03-04T04:28:59Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707947476413.82/warc/CC-MAIN-20240304033910-20240304063910-00668.warc.gz", "language_score": 0.8868054151535034, "token_count": 415, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__14564", "lang": "en", "text": "Reviews on drag reducing polymers\nMetadataShow full item record\nPolymers are effective drag reducers owing to their ability to suppress the formation of turbulent eddies at low concentrations. Existing drag reduction methods can be generally classified into additive and non-additive techniques. The polymer additive based method is categorized under additive techniques. Other drag reducing additives are fibers and surfactants. Non-additive techniques are associated with the applications of different types of surfaces: riblets, dimples, oscillating walls, compliant surfaces and microbubbles. This review focuses on experimental and computational fluid dynamics (CFD) modeling studies on polymer-induced drag reduction in turbulent regimes. Other drag reduction methods are briefly addressed and compared to polymer-induced drag reduction. This paper also reports on the effects of polymer additives on the heat transfer performances in laminar regime. Knowledge gaps and potential research areas are identified. It is envisaged that polymer additives may be a promising solution in addressing the current limitations of nanofluid heat transfer applications.\nShowing items related by title, author, creator and subject.\nShah, Milinkumar; Utikar, Ranjeet; Tade, Moses; Evans, G.; Pareek, Vishnu (2012)Formation of particle clusters in fast fluidization of fine particles significantly affects the gas-solid drag force. Accounting for the effect of clusters in gas-solid drag is critical for accurate modelling of gas-solid ...\nUtikar, Ranjeet; Tade, Moses; Evans, G.; Shah, Milinkumar (2013)Fast fluidization of fine particles leads to formation of particle clusters, which significantly affects the drag force between the phases. Existing gas–solid drag models, both empirical and theoretical, do not account ...\nVeder, Jean-Pierre M. (2010)This thesis reports on a methodology for the nanocharacterization of complex electrochemical systems. A series of powerful techniques have been adapted and applied to studies of two scientifically important electrochemical ...", "domain": "chemistry", "round": 3} +{"url": "https://store2807225.ecwid.com/Fritz-Pak-Supercizer-5-p29479099", "date": "2019-06-26T19:57:21Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-26/segments/1560628000545.97/warc/CC-MAIN-20190626194744-20190626220744-00046.warc.gz", "language_score": 0.8770266771316528, "token_count": 371, "dump": "CC-MAIN-2019-26", "global_id": "webtext-fineweb__CC-MAIN-2019-26__0__198761941", "lang": "en", "text": "* Slump control at the job site without additional water. * Higher early and ultimate strengths. * Improves concrete workability with no loss in strength. * Addition of Supercizer 5 will not affect the water-cement ratio. * Higher strengths may be achieved more economically. * Improves cohesiveness and reduces concrete segregation. * Produces concrete with lower permeability. * Concrete achieves higher durability. * Allows concrete placement in difficult access or heavily reinforced areas. * Concrete produced with Supercizer 5 can be used in the ready mix or prestressed/precast concrete industry. * Reduced shrinkage cracks and creep. * Higher modulus of elasticity. * Supercizer 5 is packaged in a water-soluble Fritz-Pak inner bag for convenient use at plant or job site, eliminating the need for admixture dispensers.\nFritz-Pak Supercizer 5 is a dry powdered admixture, packaged in a ready-to-use water-soluble bag. Supercizer 5 is formulated to produce stronger more durable concrete. As a superplasticizer, Supercizer 5 may be added with the normal amount of mix water to produce more flowable concrete with up to a 6-inch (15 centimeter) slump increase. When used as a high-range water reducer, Supercizer 5 will reduce water requirements up to 25%, increase concrete compressive strength at all ages, reduce permeability and increase durability. Supercizer 5 does not contain calcium chloride, nitrates, nitrites or other potentially corrosive materials and is compatible with all standard concrete admixtures.\nSupercizer 5 is compatible with all air-entraining admixtures, calcium chloride and other admixtures. When used with other admixtures, each admixture must be dispensed separately into the mix.", "domain": "chemistry", "round": 3} +{"url": "https://acs.figshare.com/articles/dataset/Quantitative_Phosphoproteomic_Analysis_of_Early_Alterations_in_Protein_Phosphorylation_by_2_3_7_8_Tetrachlorodibenzo_i_p_i_dioxin/2448289/1", "date": "2023-12-09T12:30:33Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100909.82/warc/CC-MAIN-20231209103523-20231209133523-00798.warc.gz", "language_score": 0.8249207735061646, "token_count": 554, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__185623161", "lang": "en", "text": "pr3009429_si_009.xls (1.67 MB)\nQuantitative Phosphoproteomic Analysis of Early Alterations in Protein Phosphorylation by 2,3,7,8-Tetrachlorodibenzo‑p‑dioxin\ndatasetposted on 2013-02-01, 00:00 authored by Melanie Schulz, Stefanie Brandner, Carola Eberhagen, Friederike Eckardt-Schupp, Martin R. Larsen, Ulrich Andrae\nA comprehensive quantitative analysis of changes in protein phosphorylation preceding or accompanying transcriptional activation by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in 5L rat hepatoma cells was performed using the SILAC approach. Following exposure of the cells to DMSO or 1 nM TCDD for 0.5 to 2 h, 5648 phosphorylated peptides corresponding to 2156 phosphoproteins were identified. Eight peptides exhibited a statistically significantly altered phosphorylation because of TCDD exposure and 22 showed a regulation factor of ≥1.5 in one of the experiments per time point. The vast majority of the TCCD-induced phosphorylation changes had not been reported before. The transcription factor ARNT, the obligate partner for gene activation by the TCDD-bound Ah receptor, exhibited an up-regulation of its Ser77 phosphorylation, a modification known to control the differential binding of ARNT homodimers and heterodimers to different enhancers suggesting that this phosphorylation represents a novel mechanism contributing to the alteration of gene expression by TCDD. Other proteins with altered phosphorylation included, among others, various transcriptional coregulators previously unknown to participate in TCDD-induced gene activation, regulators of small GTPases of the Ras superfamily, UBX domain-containing proteins and the oncogenic protein LYRIC. The results open up new directions for research on the molecular mechanisms of dioxin action and toxicity.\ngene expressionProtein PhosphorylationARNT homodimersSILAC approachregulation factortranscriptional coregulatorsdioxin action2 hQuantitative Phosphoproteomic AnalysisSer 77 phosphorylationprotein phosphorylationUBXobligate partner5 L rat hepatoma cells5648 phosphorylated peptidesOther proteinstranscriptional activation1 nM TCDDtime point2156 phosphoproteinstranscription factor ARNTgene activationTCDD exposureoncogenic protein LYRICnovel mechanismRas superfamilyDMSO", "domain": "chemistry", "round": 3} +{"url": "https://medical-dictionary.thefreedictionary.com/GRASE", "date": "2022-07-03T15:55:55Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-27/segments/1656104244535.68/warc/CC-MAIN-20220703134535-20220703164535-00691.warc.gz", "language_score": 0.9204676151275635, "token_count": 317, "dump": "CC-MAIN-2022-27", "global_id": "webtext-fineweb__CC-MAIN-2022-27__0__4699355", "lang": "en", "text": "However, two other ingredients PABA and trolamine salicylate--are not GRASE\nfor use in sunscreens because of safety issues, Theresa Michele, MD, director of the Division of Nonprescription Drug Products Division of Nonprescription Drug Products in the FDA's Center for Drug Evaluation and Research.\nIf you read the new proposed monograph, the FDA approved as GRASE\n(Category I) only zinc oxide and titanium dioxide.\nStatus of Active Ingredients listed in the stayed 1999 Final Monograph.\n* Change Generally Recognized as Safe and Effective (GRASE\nFor Proposed Orders stating that more information is needed, necessary data must be submitted in order to obtain a GRASE\nBased on new scientific information and concerns expressed by outside scientific and medical experts on an FDA advisory committee, the agency is requesting additional scientific data to demonstrate that health care antiseptics in the over-the-counter drug monograph are generally recognized as safe and effective (GRASE\n) for their intended use to reduce bacteria that potentially can cause disease.\nFirst, the FDA implemented a new requirement that any new UV filters considered by the TEA process must pass the stringent requirements of GRASE\n(Generally Recognized As Safe and Effective), a standard that exceeds the requirements of the very costly and time consuming New Drug Application (NDA).\nThe new hurdle set by the FDA is that all such ingredients must pass the stringent requirements of GRASE\n(Generally Recognized as Safe and Effective).", "domain": "chemistry", "round": 3} +{"url": "https://www.journalimcms.org/special_issue/nutrient-concentration-and-load-analysis-at-langat-river-basin/", "date": "2023-10-02T21:35:27Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233511021.4/warc/CC-MAIN-20231002200740-20231002230740-00287.warc.gz", "language_score": 0.8568924069404602, "token_count": 986, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__285870954", "lang": "en", "text": "Authors:Nor Faiza Abd Rahman,Juliza Mohamad,Munira Mohammad,Mohamad Shakri Mohamad Shariff,Vin Cent Tai, Khairi Khalid,\nKeywords:Nutrient,Total Phosphorus,Total Nitrogen,Langat River Basin,,\nAbstractWater is one of the most important elements required by all living organisms. However, uncontrolled developments and human activities have significantly affected the water quality in the river. Excessive nutrient discharge into the river will lead to many problems such as eutrophication, apart from disturbing the water supply. This study has been conducted to determine the nutrient concentration and nutrient loads in the Langat River Basin in terms of total phosphorus (TP) and total nitrogen (TN), as well as their relationship with the rainfall. Four stations from the Langat River Basin upstream have been selected for this study. The water samples were collected weekly for six months spanning both dry and wet seasons. Two standard methods for examination of water and wastewater were chosen to determine the TN and TP concentration in the water sample. Method 8190 was used for TP while, TN was measured using Method 10071. The results showed that the nutrients in the water bodies generally were influenced by the land use, climate and stream flow of the river. The TN concentration for all four stations were within the USEPA limit. On the contrary, the TP concentration for all stations exceeded the USEPA limit, indicated that limiting nitrogen condition might happen and triggered algae bloom.\nI. D. C. Whitehead, Nutrient Elements in Grassland: soil-plant-animal relationship. New Yory, USA: CABI Publishing, 2000.\nII. D. D. Tilman, Nutrient Pollution of Coastal Rivers, Bays, and Seas. Washington: Ecological Society of America, 2000.\nIII. H. Juahir, S. M. Zain, M. K. Yusoff, T. Hanidza, A. M. Armi, M. E. Toriman, M. Mokhtar, “Spatial water quality assessment of Langat River Basin (Malaysia) using environ metric techniques”, Environ Monitoring and Assessment, Vol: 173, Issue: 1-4, pp. 625-641, 2011.\nIV. H. Li, J. Hun-Wei, L. M. Cai, “Nutrient Load Estimation Methods For Rivers”, International Journal of Sediment Research, Vol: 18, Issue: 4, pp. 346-351, 2003.\nV. Helsinki Commission, Eutrophication in the Baltic Sea – An integrated thematic assessment of the effects of nutrient enrichment. Finland: Baltic Marine Environment Protection Commission, 2009.\nVI. K. McArthur, M. Clark, Nitrogen and Phosphorus Loads to Rivers in the Manawatu-Wanganui Region: An Analysis of Low Flow State: Technical Report to Support Policy Development. Horizons Regional Council, 2007.\nVII. M. K. Lindenberg, The Quantity, Characteristics, Source and Nutrient Input Of Groundwater Seepage Into The Indian River Lagoon. Florida: University of Florida, 2001.\nVIII. N. M. Pieterse, W. Bleuten, S. E. Jørgensen, “Contribution of point sources and diffuse sources to nitrogen and phosphorus loads in lowland river tributaries”, Journal of Hydrology, Vol: 271, Issue: 1-4, pp. 213-225, 2003.\nIX. S. Bricker, B. Longstaff, W. Dennison, A. Jones, K. Boicourt, C. Wicks, J. Woerner, “Effects of nutrient enrichment in the nation’s estuaries: A decade of change”, Harmful Algae, Vol: 8, Issue: 1, pp. 21–32, 2008.\nX. United States Environmental Protection Agency, Nitrogen and Phosphorus Pollution Data Access Tool. Retrieved November 1, 2014, from: http://www2.epa.gov.\nXI. World Health Organization and European Commission, Eutrophication and health. Luxembourg: Office for Official Publications of the European Communities, 2002.\nXII. Y. P. Sheng, E. A. Yassuda, C. Yang, Modeling the Impact of Nutrient Load Reduction on Water Quality and Sea grass in Roberts Bay and Little Sarasota Bay. Florida: Coastal & Oceanographic Engineering Department, University of Florida, 1995.", "domain": "chemistry", "round": 3} +{"url": "https://www.thermofisher.com/antibody/product/IFT80-Antibody-Polyclonal/PA5-28970", "date": "2017-06-24T15:48:03Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-26/segments/1498128320264.42/warc/CC-MAIN-20170624152159-20170624172159-00608.warc.gz", "language_score": 0.7272114753723145, "token_count": 423, "dump": "CC-MAIN-2017-26", "global_id": "webtext-fineweb__CC-MAIN-2017-26__0__175687994", "lang": "en", "text": "Immunofluorescent analysis of IFT80 showing staining in the centrosome of NT2D1 cells. NT2D1 cells were fixed in ice-cold MeOH for 5 min and stained using an IFT80 polyclonal antibody (Product # PA5-28970) diluted at 1:500. Blue: Hoechst 33342 staining. Scale bar = 10µm.\n|Tested species reactivity||Human|\n|Host / Isotype||Rabbit / IgG|\n|Immunogen||Recombinant fragment corresponding to a region within amino acids 114 and 362 of Human IFT80|\n|Purification||Antigen affinity chromatography|\n|Storage buffer||0.1M tris glycine, pH 7, with 10% glycerol|\n|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|\n|Tested Applications||Dilution *|\n|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|\n|Western Blot (WB)||1:500-1:3000|\n* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.\nPA5-28970 targets IFT80 in IHC (P) and WB applications and shows reactivity with Human samples.\nThe PA5-28970 immunogen is recombinant fragment corresponding to a region within amino acids 114 and 362 of Human IFT80.\nThe IFT80 gene encodes a protein with 7 WD40 domains that is a component of the intraflagellar transport (IFT) complex B (Beales et al., 2007 [PubMed 17468754]). The IFT is essential for the development and maintenance of motile and sensory cilia.\nFor Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.", "domain": "chemistry", "round": 3} +{"url": "https://www.freddabranyon.com/blog/fast-foods-disrupting-chemicals/", "date": "2018-10-20T17:47:21Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-43/segments/1539583513009.81/warc/CC-MAIN-20181020163619-20181020185119-00498.warc.gz", "language_score": 0.9521810412406921, "token_count": 1027, "dump": "CC-MAIN-2018-43", "global_id": "webtext-fineweb__CC-MAIN-2018-43__0__106543125", "lang": "en", "text": "Are you a fast food junkie? If you are, you may want to rethink the costly convince that could possibly be making you sicker each time you are trying to save time or just being too lazy to cook. I can say that because I have been guilty of it more than I would like to admit.\nMany ingredients are found in fast food that can compromise your health. These convenience meals come with endocrinedisrupting chemicals. Studies have proved that people eating drive-through hamburgers and takeout pizzas have higher levels of phthalates in their urine. The Centers for Disease Control and Prevention stated that between 2003 and 2010, data revealed urine tests from 8,900 people of all ages had higher levels of phthalates. This is defined as food from restaurants without “table service” as McDonald’s, Pizza Hut, sandwich shops, Starbucks and other casual dining and reported by Time Magazine. They found that higher levels of two substances occur when phthalates break down in the body. These two substances are DEHP and DiNP.\nThis would certainly make a lot of people take a second look at that quick trip through the drivein window! It may be faster, but not safer or healthy. Those who got 35% of their calories from fast food in a 24 hour period had nearly 24% higher levels of DEHP and 39 % higher DiNP in their urine than those who had not consumed any fast food. Studies show exposure to the phthalate metabolite DEHP can damage the liver, kidneys, lungs and reproductive system, especially the developing testes of prenatal and neonatal males. Now that is something to think about. Research has also linked both DEHP and DiNP to increased insulin resistance in adolescents.\nDi(2ethylhexyl) phthalate (DEHP) is a highly lipophilic (fatsoluble) chemical that is loosely chemically bonded to the plastic, allowing it to leach out into other fatcontaining solutions in contact with the plastic.\nDiisononyl Phthalate (DiNP), is a commonly used plasticizer in flexible PVC products. Even though considered harmless from a health and environmental perspective, more recent research suggests it may in fact have similar effects as DEPH and other phthalates.\nIsn’t it ironic that we might be eating a plastic substance? Not something I want to do. Avoiding the fast food line can be a simple way to cut Phthalate exposure. One reason fast food exposes you to higher levels of plasticizing chemicals is because workers use plastic gloves when handling each and every ingredient, and that’s a source of phthalate contamination, too, over and beyond the actual packaging. Japan actually banned vinyl gloves for use in food establishments back in 2001 due to their phthalate content. In the U.S. the use of vinyl gloves has actually increased.\nThe National Restaurant Association and the American Chemical Society respond saying that the phthalate levels found in fast food are “well below” levels the U.S. Environmental Protection Agency (EPA) deems potentially harmful to human health. However, EPA safety levels for DEHP have not been revised since 1988. Wouldn’t it be interesting to see what a new study by EPA would show?\nHealth risks associated with Phthalates are “genderbending” chemicals causing males of all species to become more female. The chemicals have disrupted the endocrine systems of wildlife, causing testicular cancer, genital deformations, low sperm counts and infertility in a number of species that scientists suspect may affect human fertility and reproduction. The endocrine system plays a role in regulating mood, growth and development, tissue function and metabolism. Here are some examples that have been found:\n- Reduced IQ in children\n- Decreased dysgenesis syndrome\n- Interference with sexual differentiation in utero\n- Enlarged prostate glands, testicular cancer, breast cancer and uterine fibroids\n- Impaired ovulatory cycles and polycystic ovary disease\n- Numerous hormonal disruptions and metabolic disease\n- Early or delayed puberty\n- Disturbed lactation\n- Toxicity to developing male reproductive systems\n- Neurodevelopmental delays, inattention, hyperactivity and symptoms of autism\n- Miscarriage and preterm birth\n- Allergies and respiratory problems\nJust remember that Phthalates are everywhere and among the most pervasive of all known endocrine disrupters. More than 470 million pounds of phthalates are produced each year. Just a few tips to help you avoid those endocrine disrupting chemicals try to avoid fast-food, use natural cleaning products, Eat organic diets, buy products in glass, not plastic or cans, store food in glass, use glass baby bottles and replace your vinyl shower curtain with fabric or glass doors. There are many others but basically, avoid plastics wherever you can. Let’s all do our part to make this world healthier and keep our body is good working condition.\n–Dr Fredda Branyon", "domain": "chemistry", "round": 3} +{"url": "https://chem.washington.edu/research/publications/flare-feature-rich-covalent-stains-super-resolution-and-cleared-tissue", "date": "2023-11-30T23:51:08Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100258.29/warc/CC-MAIN-20231130225634-20231201015634-00842.warc.gz", "language_score": 0.8617385625839233, "token_count": 333, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__196698638", "lang": "en", "text": "Fluorescence microscopy is a workhorse tool in biomedical imaging but often poses substantial challenges to practitioners in achieving bright or uniform labeling. In addition, while antibodies are effective specific labels, their reproducibility is often inconsistent, and they are difficult to use when staining thick specimens. We report the use of conventional, commercially available fluorescent dyes for rapid and intense covalent labeling of proteins and carbohydrates in super-resolution (expansion) microscopy and cleared tissue microscopy. This approach, which we refer to as Fluorescent Labeling of Abundant Reactive Entities (FLARE), produces simple and robust stains that are modern equivalents of classic small-molecule histology stains. It efficiently reveals a wealth of key landmarks in cells and tissues under different fixation or sample processing conditions and is compatible with immunolabeling of proteins and in situ hybridization labeling of nucleic acids.\nYou are here\nFLARE: Feature-Rich Covalent Stains for Super-Resolution and Cleared-Tissue Fluorescence Microscopy\nMao, C.; Lee, M. Y.; Jhan, J.-R.; Halpern, A. R.; Woodworth, M. A.; Glaser, A. K.; Chozinski, T. J.; Shin, L.; Pippin, J.W.; Shankland, S.J.; Liu, J. T. C.; Vaughan, J. C. Feature-Rich Covalent Stains for Super-Resolution and Cleared-Tissue Fluorescence Microscopy. Sci. Adv. 2020, 6, eaba4542.", "domain": "chemistry", "round": 3} +{"url": "https://stat.osu.edu/events/seminar-ewy-mathe", "date": "2019-04-24T12:50:19Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-18/segments/1555578641278.80/warc/CC-MAIN-20190424114453-20190424140453-00453.warc.gz", "language_score": 0.8772196173667908, "token_count": 278, "dump": "CC-MAIN-2019-18", "global_id": "webtext-fineweb__CC-MAIN-2019-18__0__148630644", "lang": "en", "text": "User-Friendly Approaches to Integrating Metabolomics Data with Other Omics\nEwy Mathe, Department of Biomedical Informatics, The Ohio State University\nTranslational, clinical, and basic science researchers are generating omics data in the same samples to explore the molecular underpinnings of complex diseases. Of the omics, metabolomics, which aims to measure small molecules such as carbohydrates, hormones, amino acids, nucleotides, xenobiotics, and lipids, is increasingly applied. Analysis of these integrated datasets and functional interpretation of disease-associated metabolites is difficult, and is often hampered by the lack of user-friendly computational tools. To facilitate such analyses, we have developed user-friendly approaches that 1) numerically integrate gene expression and metabolite measurements to identify phenotype- (e.g. cancer) specific gene-metabolite relationships (https://github.com/Mathelab/IntLIM), and 2) perform pathway over-representation analysis using a comprehensive database of biological pathways (https://github.com/Mathelab/RaMP-DB). Application of these approaches facilitates integration of metabolomics and other omics data, with the goal of expanding our understanding of the molecular mechanisms that underlie cancer and other diseases.\nNote: Seminars are free and open to the public. Reception to follow.", "domain": "chemistry", "round": 3} +{"url": "http://deiodinase.org/2001/08/10/the-human-type-2-iodothyronine-deiodinase-is-a-selenoprotein-highly-expressed-in-a-mesothelioma-cell-line/", "date": "2024-04-14T20:27:22Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712296816893.9/warc/CC-MAIN-20240414192536-20240414222536-00813.warc.gz", "language_score": 0.8693796992301941, "token_count": 557, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__151056534", "lang": "en", "text": "Types 1 and 3 iodothyronine deiodinases are known to be selenocysteine-containing enzymes. Although a putative human type 2 iodothyronine deiodinase (D2) gene (hDio2) encoding a similar selenoprotein has been identified, basal D2 activity is not selenium (Se)-dependent nor has D2 been labeled with 75Se. A human mesothelioma cell line (MSTO- 211H) has recently been shown to have 40-fold higher levels of hDio2 mRNA than mesothelial cells. Mesothelioma cell lysates activate thyroxine (T4) to 3,5,3 -triiodothyronine with typical characteristics of D2 such as low Km (T4), 1.3 nM, resistance to propylthiouracil, and a short half-life ( 30 min). D2 activity is 30-fold higher in Se-supplemented than in Se-depleted medium. An antiserum prepared against a peptide deduced from the Dio2 mRNA sequence precipitates a 75Se protein of the predicted 31-kDa size from 75Se-labeled mesothelioma cells. Bromoadenosine 3 5 cy- clic monophosphate increases D2 activity and 75Se-p31 2.5-fold whereas substrate (T4) reduces both D2 activity and 75Se-p31 2–3-fold. MG132 or lactacystin (10 M), inhib- itors of the proteasome pathway by which D2 is degraded, increase both D2 activity and 75Se-p31 3–4-fold and prevent the loss of D2 activity during cycloheximide or substrate (T4) exposure. Immunocytochemical studies with affinity- purified anti-hD2 antibody show a Se-dependent increase in immunofluorescence. Thus, human D2 is encoded by hDio2 and is a member of the selenodeiodinase family ac- counting for its highly catalytic efficiency in T4 activation.\nThe Human Type 2 Iodothyronine Deiodinase Is a Selenoprotein Highly Expressed in a Mesothelioma Cell Line.\nCyntia Curcio, Munira M. A. Baqui, Domenico Salvatore, Bertrand H. Rihn, Steve Mohr, John W. Harney, P. Reed Larsen, and Antonio C. Bianco. Journal of Biological Chemistry. August 10, 2001. doi: 10.1074/jbc.C100325200", "domain": "chemistry", "round": 3} +{"url": "https://avesis.medeniyet.edu.tr/publication/details/c2eee571-9a64-4531-a982-0d28a9c6102c/comparative-effect-of-angiotensin-converting-enzyme-inhibition-and-angiotensin-ii-type-1-receptor-antagonism-on-plasma-fibrinolytic-balance-in-humans", "date": "2022-08-17T10:26:30Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882572898.29/warc/CC-MAIN-20220817092402-20220817122402-00051.warc.gz", "language_score": 0.9101253151893616, "token_count": 644, "dump": "CC-MAIN-2022-33", "global_id": "webtext-fineweb__CC-MAIN-2022-33__0__182630860", "lang": "en", "text": "Angiotensin-converting enzyme (ACE) inhibition significantly decreases plasminogen activator inhibitor-1 (PAI-1) without altering tissue plasminogen activator (tPA) during activation of the renin-angiotensin-aldosterone system in humans. Because ACE inhibitors and angiotensin II type 1 (AT(1)) receptor antagonists differ in their effects on angiotensin II formation and bradykinin degradation, the present study compared the effect of equivalent hypotensive doses of an ACE inhibitor and AT(1) antagonist on fibrinolytic balance. Plasma PAI-1 antigen, tPA antigen, plasma renin activity, and aldosterone were measured in 25 normotensive subjects (19 white, 6 black; 14 men, 11 women; mean age 38.5+/-1.8 years; mean body mass index 25.3+/-0.7 kg/m(2)) during low salt intake alone (10 mmol Na/d), low salt intake + quinapril (40 mg PO bid), and low salt intake + losartan (50 mg PO bid). Compared with low salt alone (systolic blood pressure [BP] 118.8+/-2.2 mmHg), both quinapril (106.3+/-2.5 mmHg, P<0.001) and losartan (105.4+/-2.8 mm Hg, P<0.001) reduced BP. No statistical difference was found between quinapril and losartan in their BP lowering effect. Losartan (P=0.009), but not quinapril, lowered heart rate. Both drugs significantly lowered aldosterone (P<0.001 versus low salt alone for each); however, this effect was significantly greater for quinapril than for losartan (P<0.001 for quinapril versus losartan). Treatment with quinapril, but not with losartan, was associated with a decrease in both PAI-1 antigen (P=0.03) and activity (P=0.018). PAI-1 activity was lower during treatment with quinapril than with losartan (P=0.015). The average PAI-1 antigen concentration was 13.0+/-2.0 ng/mL during low salt alone, 10.5+/-1.6 ng/mL during quinapril treatment, and 12.3+/-2.1 ng/mL during losartan treatment. In contrast, plasma tPA antigen concentrations were reduced during treatment with losartan (P=0.03) but not with quinapril. This study provides the first evidence that ACE inhibitors and AT(1) antagonists differ in their effects on fibrinolytic balance under conditions of activation of the renin-angiotensin-aldosterone system. Further studies are needed to address the mechanism for the contrasting effects of these 2 classes of drugs on fibrinolysis and to define the clinical significance of these differences.", "domain": "chemistry", "round": 3} +{"url": "https://www.ars.usda.gov/research/publications/publication/?seqNo115=287140", "date": "2021-11-27T16:59:22Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-49/segments/1637964358208.31/warc/CC-MAIN-20211127163427-20211127193427-00573.warc.gz", "language_score": 0.8619312047958374, "token_count": 608, "dump": "CC-MAIN-2021-49", "global_id": "webtext-fineweb__CC-MAIN-2021-49__0__185397299", "lang": "en", "text": "Location: Crop Bioprotection ResearchTitle: Genomic analysis and secondary metabolite production in Bacillus amyloliquefaciens AS 43.3: a biocontrol antagonist of fusarium head blight\nSubmitted to: Biocontrol\nPublication Type: Peer Reviewed Journal\nPublication Acceptance Date: 11/13/2012\nPublication Date: 1/5/2013\nCitation: Dunlap, C.A., Bowman, M.J., Schisler, D.A. 2013. Genomic analysis and secondary metabolite production in Bacillus amyloliquefaciens AS 43.3: A biocontrol antagonist of Fusarium head blight. Biocontrol. 64(1):166-175.\nInterpretive Summary: We have sequenced and assembled the complete genome of a beneficial bacteria useful in controlling diseases in wheat. The research will allow us to determine how these beneficial bacteria are able to biologically control plant pathogens. The work provides a blueprint of the number and types compounds the beneficial bacteria can produce, such antifungal compounds toxic to plant pathogens. This breakthrough improves our knowledge of the mode-of-action these beneficial bacteria use, which provides insight on how we may improve their efficacy on crops in the field. Understanding how these beneficial bacteria can control plant diseases has the potential to lead to new methods of crop protection for wheat farmers.\nTechnical Abstract: The complete genome of the biocontrol antagonist Bacillus amyloliquefaciens AS 43.3 is reported. The 3.9 Mbp genome was sequenced, assembled, and annotated. Genomic analysis of the strain identified ten biosynthetic gene clusters encoding secondary metabolites associated with biocontrol activity. The analysis identified five non-ribosomal peptide synthetase clusters encoding three lipopeptides (surfactin, iturin, and fengycin), a siderophore (bacillibactin), and the antibiotic dipeptide bacilysin. In addition, three polyketide synthetase clusters were identified which encoded for the antibacterials, bacillaene, difficidin, and macrolactin. In addition to the non-ribosomal mediated biosynthetic clusters discovered, we identified a ribosomally encoded biosynthetic cluster that produces the antibiotic plantazolicin. To confirm the gene clusters were functional, cell-free culture supernatant was analyzed using LC-MS/MS. The technique confirmed the presence of all ten metabolites or their derivatives. The study suggests the strain is mostly likely a member of the B. amyloliquefaciens subsp plantarium clade. This study demonstrates the growing importance of applying genomic-based studies to biocontrol organisms of plant pathogens which can enable the rapid identification of bioactive metabolites produced by a prospective biological control organism.", "domain": "chemistry", "round": 3} +{"url": "http://kvanta.ua/ebooks/advanced-gas-chromatography-prog-in-agric-biomed-ind-applns", "date": "2021-12-03T04:24:26Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-49/segments/1637964362589.37/warc/CC-MAIN-20211203030522-20211203060522-00282.warc.gz", "language_score": 0.7878011465072632, "token_count": 922, "dump": "CC-MAIN-2021-49", "global_id": "webtext-fineweb__CC-MAIN-2021-49__0__27106890", "lang": "en", "text": "By M. Mohd\nRead Online or Download Advanced Gas Chromatography - Prog. in Agric., Biomed., Ind. Applns. PDF\nBest nonfiction_7 books\nEmbedded structures are informally outlined as a suite of programmable elements surrounded by means of ASICs and different ordinary elements, that have interaction always with an atmosphere via sensors and actuators. The programmable elements contain micro-controllers and electronic sign Processors (DSPs). Embedded structures are usually utilized in life-critical occasions, the place reliability and safeguard are extra vital standards than functionality.\nMathematical modeling of human physiopathology is a enormously bold activity. It encompasses the modeling of such a lot various cubicles corresponding to the cardiovascular, respiration, skeletal and fearful platforms, in addition to the mechanical and biochemical interplay among blood move and arterial partitions, or electrocardiac techniques and the electrical conduction into organic tissues.\nThe publication provides the present country of stories of element defects, either intrinsic and extrinsic (impurities, radiation facilities, and so forth. ), in LiNbO3. The contribution of intrinsic defects to photoinduced cost delivery, i. e. to the photorefraction, is defined. The photorefractive and optical houses of LiNbO3 crystals with diversified stoichiometry and of these doped with so-called \"optical-damage resistant\" impurities controlling the intrinsic illness constitution are defined intimately.\n- Emergence in Complex, Cognitive, Social, and Biological Systems\n- Beginning Digital Image Processing: Using Free Tools for Photographers\n- The radiochemistry of cadmium\n- Handbook of cellular metals : production, processing, applications [4 Vols]\n- Advances in CAD/CAM Workstations: Case Studies\nExtra info for Advanced Gas Chromatography - Prog. in Agric., Biomed., Ind. Applns.\nComprehensive Two-Dimensional Gas Chromatography using an On-column Thermal Desorption Modulator Interface, Journal of Chromatographic Science, Vol. 29, No. 6, (June 1991), pp. 227–231, ISSN 0021-9665 Larsson, L. & Saraf, A. (1997). Use of Gas Chromatography-Ion Trap Tandem Mass Spectrometry for the Detection and Characterization of Microorganisms in Complex Samples. Molecular Biotechnology, Vol. 7, No. 3 (June 1997), pp. 279-287, ISSN 1559-0305 Low, M. & Freeman, S. (1967). Measurement of Infrared Spectra of Gas-Liquid Chromatography Fractions using Multiple-Scan Interference Spectrometry.\n20 (October 2010), pp. 8618-8628, ISSN 0003-2700 Plomley, J; Lausevic, M. & March, R. (2000). Determination of Dioxins/Furans and PCBs by Quadrupole Ion-Trap Gas Chromatography–Mass Spectrometry. Mass Spectrometry Review, Vol. 19, No. 5 (September 2000), pp. ; Hernández, F. & Niessen, W. (2011). Use of Soft and Hard Ionization Techniques for Elucidation of Unknown Compounds by Gas Chromatography / Time-of-Flight Mass Spectrometry. Rapid Communications in Mass Spectrometry, Vol. (25), No. 11 (June 2011), pp.\nInvestigation of High Sensitivity GC-FTIR as an Analytical Tool for Structural Identification. Journal of High Resolution Chromatography, Vol. 16, No. (September 1993), pp. 515-521, ISSN 0935-6304 Jaeger, H. (1987). Capillary Gas Chromatography-Mass Spectrometry in Medicine and Pharmacology, Dr. Alfred Huethig, ISBN 3-7785-1375-3, Heidelberg, Germany James, A. & Martin, J. (1952). Gas-Liquid Partition Chromatography; the Separation and Micro-estimation of Volatile Fatty Acids from Formic Acid to Dodecanoic Acid.\nAdvanced Gas Chromatography - Prog. in Agric., Biomed., Ind. Applns. by M. Mohd", "domain": "chemistry", "round": 3} +{"url": "http://www.genomebiology.com/2005/6/6/R55/abstract", "date": "2015-11-25T14:20:20Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2015-48/segments/1448398445208.17/warc/CC-MAIN-20151124205405-00096-ip-10-71-132-137.ec2.internal.warc.gz", "language_score": 0.8685010671615601, "token_count": 275, "dump": "CC-MAIN-2015-48", "global_id": "webtext-fineweb__CC-MAIN-2015-48__0__48950361", "lang": "en", "text": "Refinement and prediction of protein prenylation motifs\nIMP - Research Institute of Molecular Pathology, Dr. Bohr-Gasse 7, A-1030 Vienna, Austria\nGenome Biology 2005, 6:R55 doi:10.1186/gb-2005-6-6-r55Published: 27 May 2005\nWe refined the motifs for carboxy-terminal protein prenylation by analysis of known substrates for farnesyltransferase (FT), geranylgeranyltransferase I (GGT1) and geranylgeranyltransferase II (GGT2). In addition to the CaaX box for the first two enzymes, we identify a preceding linker region that appears constrained in physicochemical properties, requiring small or flexible, preferably hydrophilic, amino acids. Predictors were constructed on the basis of sequence and physical property profiles, including interpositional correlations, and are available as the Prenylation Prediction Suite (PrePS, http://mendel.imp.univie.ac.at/sat/PrePS webcite) which also allows evaluation of evolutionary motif conservation. PrePS can predict partially overlapping substrate specificities, which is of medical importance in the case of understanding cellular action of FT inhibitors as anticancer and anti-parasite agents.", "domain": "chemistry", "round": 3} +{"url": "https://ci.lib.ncsu.edu/profiles/5979", "date": "2023-10-01T00:23:17Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233510730.6/warc/CC-MAIN-20230930213821-20231001003821-00412.warc.gz", "language_score": 0.6643785238265991, "token_count": 286, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__156207271", "lang": "en", "text": "Improving the catalytic activity of hyperthermophilic Pyrococcus prolidases for detoxification of organophosphorus nerve agents over a broad range of temperatures\nApplied Microbiology and Biotechnology, 87(5), 1715–1726.\nauthor keywords: Prolidase; Pyrococcus furiosus; OP nerve agents; Mutagenesis; Directed evolution\nMeSH headings :\nAmino Acid Substitution / genetics; Archaeal Proteins / chemistry; Archaeal Proteins / genetics; Archaeal Proteins / isolation & purification; Archaeal Proteins / metabolism; Chemical Warfare Agents / metabolism; Culture Media / chemistry; Dipeptidases / chemistry; Dipeptidases / genetics; Dipeptidases / isolation & purification; Dipeptidases / metabolism; Enzyme Stability; Escherichia coli / genetics; Models, Molecular; Mutagenesis; Organophosphorus Compounds / metabolism; Pesticides / metabolism; Plasmids; Polymerase Chain Reaction / methods; Protein Stability; Protein Structure, Tertiary; Pyrococcus furiosus / enzymology; Pyrococcus furiosus / genetics; Sequence Deletion; Temperature\nSources: Web Of Science, Crossref, ORCID\nAdded: August 6, 2018", "domain": "chemistry", "round": 3} +{"url": "https://jes.ut.ac.ir/article_21470.html?lang=en", "date": "2024-02-29T20:31:11Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707947474853.43/warc/CC-MAIN-20240229202522-20240229232522-00556.warc.gz", "language_score": 0.894085705280304, "token_count": 266, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__174560741", "lang": "en", "text": "Landfill gas is generated by organic waste decomposing under anaerobic conditions. landfill gas contributes to the emission in the atmosphere of greenhouse gases and causing global warming. Humidity of environment is an effective parameter on rate of gas generation in landfills. Saravan landfill is investigated as study area in this research. It located in 20 kilometers of Rasht-Tehran highway. It is modeled as an anaerobic landfill within dry and moist condition in landGEM software and amount of gas emissions in calculated per year. Results of the study show the rate of gas generation in moist condition is 3.85 times of dry condition. In Saravan landfill ,the maximum generation rate of methane,carbon dioxide and Non-methane Volatile Organic Compounds (NMVOCs) was 11700, 32110 and 500 Ton/Year in moist condition and 3043, 8349, 130 Ton/Year in dry condition, respectively.In regard to effect of moist on rate of contaminants generation and humidity of the study area, using the cap as a contaminants control methods is assessed. We suggested multiple cap for the landfill. The cap caused oxidation of methane and prevent of moist into landfill, then it reduce the rate of gas and leachate generation. The designed cap has inactive gas collection and leachated drainage systems.", "domain": "chemistry", "round": 3} +{"url": "https://tudermaonline.com/en/shop/tuderma-intensive-regenerating-cream-50ml", "date": "2023-12-04T22:56:43Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100535.26/warc/CC-MAIN-20231204214708-20231205004708-00860.warc.gz", "language_score": 0.7072162628173828, "token_count": 446, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__98502906", "lang": "en", "text": "FREE DELIVERY FROM 50 €\nA lightweight, creamy texture that is easily absorbed. Smoothes and hydrates. Closes the pores and evens skin tones. It contains high tolerance glycolic acid. Suitable for sensitive skin.\nIndicated for dull skin or skin with imperfections, dilated pores, dark spots and anti-ageing purposes.\nApply in the morning on clean skin or after the serum. Use sunscreen during summer.\nWarning: Last items in stock!\nTUDERMA Intensive Regenerator has been developed to improve the skin surface by renewing the most superficial layers of the skin (epidermis) and stimulating the formation of new collagen. It is formulated in a light gel-cream texture that is easily absorbed.\nSuitable for all skin types.\nAirless 50 ml.\nAQUA, GLYCOLIC ACID, CYCLOPENTASILOXANE, PROPYLENE GLYCOL, PROPANEDIOL, CAPRYLIC/CAPRIC TRIGLYCERIDE, CYCLOHEXASILOXANE, GLYCERYL STEARATE CETYL ALCOHOL, AMMONIUM HYDROXIDE, AMMONIUM ACRYLOYLDIMETHYLTAURATE/VP COPOLYMER, ALCOHOL, BISABOLOL, BOSWELLIA SERRATA GUM, CETETH-20, DIMETHICONE, DIMETHICONOL, DIPROPYLENE GLYCOL, ETHYLHEXYLGLYCERIN, LECITHIN, MELATONIN, PARFUM, PEG-75 STEARATE PEG/PPG-18/18 DIMETHICONE, PHENOXYETHANOL, POLYSORBATE 20, SODIUM POLYACRYLATE, STEARETH-20, TOCOPHERYL ACETATE, TRANEXAMIC ACID, TRIDECETH-6, XANTHAN GUM\nCopyright 2016-2023 TUDERMA TUDERMAONLINE", "domain": "chemistry", "round": 3} +{"url": "https://www.akadeum.com/videos/introduction-to-akadeum/", "date": "2023-10-01T22:49:11Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233510941.58/warc/CC-MAIN-20231001205332-20231001235332-00130.warc.gz", "language_score": 0.9166339039802551, "token_count": 306, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__240538867", "lang": "en", "text": "At Akadeum Life Sciences, we have developed a revolutionary approach to sample preparation that uses our proprietary, buoyant microbubble technology to quickly and easily enrich your sample for the analyte(s) of interest while maintaining target cell health and physiology.\nOur buoyant approach to separation eliminates many of the existing technical hurdles that are limiting improvements or effectiveness of processes today. Unlike with magnetic bead-based separation, microbubbles do not have the same volume and equipment restrictions. Our microbubbles are gently mixed into the sample where they engage the targets, before isolating those targets through floatation-based separation. It’s that simple! We’ve taken technology that traditionally requires additional vessels and equipment to accomplish this separation and put it into a single container where it’s self-separating.\nAkadeum’s next-generation technology overcomes long-standing headaches with traditional sample preparation like magnetic bead-based separation. Akadeum’s microbubbles are equipment-free and can enable both low-volume and large-volume separations. Our sensitive and specific microbubbles enable effective capture of targets of low abundance while eliminating issues with non-specific binding. Critically, the microbubble workflow is exceptionally gentle, which is especially valuable when enriching for delicate targets that can be damaged or lost using older technology like magnetics. With microbubbles, throughput is not limited by access to expensive, specialized equipment which enables sample preparation that can be done at scale.", "domain": "chemistry", "round": 3} +{"url": "https://zytecgermbuster.ca/product/healthcare-disinfecting-wipes-all-in-one-180-wipes/", "date": "2023-06-01T16:23:02Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-23/segments/1685224647895.20/warc/CC-MAIN-20230601143134-20230601173134-00219.warc.gz", "language_score": 0.8610784411430359, "token_count": 361, "dump": "CC-MAIN-2023-23", "global_id": "webtext-fineweb__CC-MAIN-2023-23__0__199095774", "lang": "en", "text": "- DIN# 02523132\n- Kills SARS-CoV-2 the virus that causes COVID-19 in 30 seconds\n- Kills 99.99% of viruses and bacteria\n- Kills Flu Virus\n- Disinfects hard, non-porous surfaces including tabletops, doorknobs, waiting area chairs.\n- On Health Canada’s List of Hard-Surface Disinfectants with Evidence Against COVID-19\n- Proudly Made in Canada\n- For complete directions, see the product label.\nActive ingredients (w/w) : n-Alkyl (68% C12, 32% C14) dimethyl ethyl benzyl ammonium chloride …0.14 %\nn-Alkyl (5% C12, 60% C14, 30% C16, 5% C18) dimethyl benzyl ammonium chloride …0.14 %\nDirections: Remove lid and foil seal. Feed corner of the wipe located in centre of roll through hole in lid and then replace lid. Close cap after use.\nTo disinfect: Pre-clean heavily soiled areas. Use on hard, nonporous surfaces. Wipe surface to be disinfected. Allow surface to remain wet for 5 minutes (30 seconds for SARS-CoV-2 (the virus that causes COVID-19)). Let surface dry. Rinse surface prior to use. For hard surfaces and/or objects that may come into direct contact with children at the mouthing stage of development, a rinse with potable water is recommended. CLEANING: Use one wipe to completely remove dirt and debris from surfaces to be treated.\nThere are no reviews yet.", "domain": "chemistry", "round": 3} +{"url": "https://biovisi.com/supplier/24888-biovision/25433-anti-erk5-antibody", "date": "2020-12-01T06:13:33Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-50/segments/1606141652107.52/warc/CC-MAIN-20201201043603-20201201073603-00137.warc.gz", "language_score": 0.8357409834861755, "token_count": 439, "dump": "CC-MAIN-2020-50", "global_id": "webtext-fineweb__CC-MAIN-2020-50__0__18571336", "lang": "en", "text": "Target of this antibody:\nAlternative names of antibody target:\nBMK1 , ERK-5 , PRKM7 , MAPK7, Mitogen-activated protein kinase 7; MAP kinase 7; MAPK 7; Extracellular signal-regulated kinase 5; ERK-5; Big MAP kinase 1; BMK-1.\nErk-5 shares high homology in the amino-terminal kinase domain with Erk1/2. However, the long carboxy-terminal kinase domain makes Erk5 a unique MAP kinase. Erk5 is activated by a variety of extracellular signals. The direct upstream kinase of Erk5 is defined as MEK5. Studies show that Erk5 pathway is involved in proliferation, differentiation, oncogenesis, and development.\nClonality of antibody:\nThis antibody reacts with:\nHuman, mouse, rat\nSynthetic peptide from human Erk5\nConcentration of antibody:\nForm of antibody:\nFormulation of this antibody:\n100 µg (0.5 mg/ml) affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 50% glycerol, 1% BSA, and 0.02% thimerosal.\nThis antibody has been succesfully tested for use in following methods:\nWestern blotting (0.5-4 µg/ml). However, the optimal concentrations should be determined individually. The antibody recognizes ~115 kDa Erk5 of human, mouse, and rat origins.\nShelf time: 12 months in temp.: -20 deg.C\nHow to handle this antibody:\nThe antibody solution should be gently mixed before use.\nThis antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.\nIf you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.", "domain": "chemistry", "round": 3} +{"url": "https://blog.storymirror.com/read/cn6dfdvj/completing-a-hazardous-waste-collection-request-form", "date": "2022-08-15T08:01:33Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882572161.46/warc/CC-MAIN-20220815054743-20220815084743-00536.warc.gz", "language_score": 0.9420743584632874, "token_count": 859, "dump": "CC-MAIN-2022-33", "global_id": "webtext-fineweb__CC-MAIN-2022-33__0__123668174", "lang": "en", "text": "Hazardous waste is material that has potential or significant hazards to the environment or public health. The majority of hazardous waste is either abandoned or removed from a site immediately after the disposal process. However, in some cases, hazardous waste is still found on a site when disposing it would create a serious threat or danger to people, property, or the environment. These situations require innovative and creative hazardous waste disposal San Diego processes that can minimize, or in some cases, fully alleviate, the threat or danger posed by the discarded hazardous waste.\nIt is important to note that the term hazardous waste doesn't just refer to the disposal of waste in hazardous waste containers. There are many different types of hazardous waste, including radioactive materials, toxic drugs, and other dangerous chemicals. However, the majority of hazardous waste is soil-based or produced through accidental spills, dirty water supplies, or agricultural activities. Any type of hazardous waste material that is generated in a landfill or other landfill container should be clearly marked with a special decontamination tag. This will help to make sure that no one else uses or touches the waste and makes any alterations to the waste prior to proper disposal.\nIn the past, most municipalities have regulated hazardous waste disposal through mandatory regulations and landfills. For example, most cities and counties have adopted a local hazardous waste disposal plan that requires companies to safely dispose of their unwanted products. In addition, most cities and counties also have laws that mandate that companies carefully track and handle their hazardous wastes so that they do not become the cause of contamination or poisoning local water supplies. If a company is not sure about the proper disposal methods for their waste, they are required to file a request form with their local municipality. The request form explains the type of waste, how it should be disposed of, and what precautions should be taken in case of an accidental release of the hazardous waste.\nThe local government requires companies to file a request form when dealing with hazardous waste disposal. The request is then reviewed by a panel of federal and state environmental officials who determine if the conditions of the waste meet the legal requirements. If the hazardous waste disposal poses no threat to public safety, the material can be disposed of at any stage of its development. If it does pose a threat, the waste must be placed in deep well or another container such as landfills.\nMany chemicals used in industrial processes can be disposed of in a deep well. These chemicals include those used in cement mixing, oil production, rubber, caulk manufacture, paints and hydrofluoric acid. Most municipal governments require that these hazardous wastes are disposed of in deep wells. Additionally, most states require that these chemicals are contained in special hazardous waste containers for storage. However, private homes and businesses can store these chemicals in a variety of ways. In order to comply with chemical waste collection and disposition laws, it is recommended that these hazardous waste materials be kept separated from household products and sent for hazardous waste collection on a regular basis.\nThere are two primary methods of hazardous waste collection and disposal. They are known as acute and chronic hazardous waste. Incorrect disposal of solid wastes can result in severe environmental contamination and environmental pollution. As an example, if homeowners to dispose of their household's electronic equipment in regular trash cans, they may inadvertently generate toxic chemicals that leach into the soil and seep into groundwater. While these wastes may not currently pose a significant environmental threat, there is no assurance that they will not. On the other hand, proper handling of solid wastes can significantly reduce the volume of wastes that are disposed of in a timely and effective manner.\nWhen it comes to hazardous waste disposal, it is important to dispose of dangerous wastes in the right way. While it is possible to recycle certain waste materials, making sure that the right procedure is followed is essential. Most states have specific regulations regarding the placement and handling of these hazardous wastes. These regulations were designed to protect the public from the potential dangers of these wastes.\nYour local waste collection service can provide you with a complete list of prohibited activities and the requisite permits that you need to perform them. Permits to dispose of dangerous substances may be required by federal and state environmental agencies. You can find out more about hazardous waste disposal by completing a hazardous waste collection request form.", "domain": "chemistry", "round": 3} +{"url": "https://vivo.scripps.edu/display/endnote396945", "date": "2020-10-28T23:48:15Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-45/segments/1603107902038.86/warc/CC-MAIN-20201028221148-20201029011148-00429.warc.gz", "language_score": 0.9662697315216064, "token_count": 321, "dump": "CC-MAIN-2020-45", "global_id": "webtext-fineweb__CC-MAIN-2020-45__0__149492121", "lang": "en", "text": "The structural organization of the complex of Escherichia coli Ile-tRNA synthetase and tRNA Ile has been studied by isotope labeling of purine units in the tRNA. Free or bound tRNA is incubated in tritiated water for 5 to 15 h at 37 degrees in order to incorporate tritium into the C-8 positions of purine units. (Previous work has shown that the labeling rate of a purine is very sensitive to its microenvironment.) Under conditions where exchange-out does not occur, the nucleic acid is digested with nucleases and purines are subsequently isolated from known locations in the structure. Four purines are substantially perturbed by bound Ile-tRNA synthetase; in each case, the rate of labeling is retarded in the presence of the synthetase. The four purines occur at or near the 3' terminus and at the interface of the dihydrouridine stem and loop. These bases occur in segments of the tRNA that previous photochemical cross-linking studies have identified as important for synthetase-tRNA interactions. It appears that the effects observed on these sites are caused by their direct interaction with or shielding by the bound synthetase. In addition, two other sites, one in the anticodon and one in the amino acid acceptor-T psi C helix, appear to be perturbed (retarded labeling rates) by the bound enzyme. The data also suggest there is no significant conformational change in the tRNA upon binding to the synthetase.", "domain": "chemistry", "round": 3} +{"url": "https://windigo.lv/motornoe-maclo-windigo-formula-hightec-10w-40-1110575843.html", "date": "2020-02-22T06:58:17Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-10/segments/1581875145654.0/warc/CC-MAIN-20200222054424-20200222084424-00443.warc.gz", "language_score": 0.9026129841804504, "token_count": 696, "dump": "CC-MAIN-2020-10", "global_id": "webtext-fineweb__CC-MAIN-2020-10__0__8274551", "lang": "en", "text": "EcoUniversal Oil Package is an additive for lubricative oils that does notcontain solid particles, can be used for all types of engines,hydraulic systems, manual and automatic transmissions and servomotor.Has neutral behavior in mineral and synthetic engine oils, hydraulicsystems (HLP), and mineral, polysynthetic oils for automatictransmissions (ATF).\nBy virtue of ability to form solid layerthat protects from wearing, it prevents direct contact, welding, andcorrosion of metallic parts. Ensures roughness evening of metallicsurfaces and unachievable before anti abrasive property that reduceswearing. The additive helps significantly increase lifetime of devicesand mechanisms. Exploitation expenditures are decreasing and power isincreasing. Energy conversion efficiency is also increased, which isachieved due to decreased friction and heat release.\nMetallicparts movement towards each other always causes wearing. The wearing isthe outcome of friction; oil application can only partially prevent it.In case of observation of surface that is perceived completely evenunder the microscope in reality resembles dissected by gorges mountainlandscape. Therefore, all engine and industrial equipment movable partswear out during exploitation. Parts` edges move against each other, as aresult, friction temperatures up to 1800 С appears in micro areas.Under such high temperatures edges of metallic parts weld together,which causes solid connection, this in turn causes metallic edges tobreak off, consequently it leads to wearing off and shavings formation.Surface become more rough. Eco Universal Oil Package chemically bindswith metallic surfaces` molecules and forms new microscopicmonomolecular protective layer, which prevents wearing of metallicdetails under friction. In result evening of all surface decreaseswearing, it leads to unique unachieved before work quality under extremeloads. After smoothing the surface, it ensures practically perfectliquid friction state, almost completely avoiding dry, boundary andmixed friction (for example, when starting cold engine, excessive loadsand high rotation speed). The most ideal conditions for surface areformed that allows mechanisms to work without friction and wearing.Refinement of surfaces is taking place.\nAdditive work process ECO-Universal Oil Package\nEngine oil - WINDIGO Formula HIGHTEC 10W-40\nWINDIGO Formula HIGHTEC 10W-40 is an ultra-high-performance diesel engine oil (UHPD engine oil) based on the latest generation of base oils produced by HC-Synthesis-Technology. The development of this product focused on the fulfillment of the strict requirements of the latest generation of Euro IV & V engines. By using a new \"Low-SAPS-Technology\" (reduced content of sulfated ash, phosphorus and sulfur) the required specifications were exceeded by far. The formulation of the product allows extended drain intervals up to 100,000 km in compliance with the operating rules of the individual vehicle manufacturer. WINDIGO Formula HIGHTEC 10W-40 offers many advantages:\n• High-performance additives with dispersing properties minimize the risk of oil thickening and sludge formation.\n• Excellent protection against fretting and galling.\n• Minimized wear protects the diesel engines and prolongs its life.\n• Highly improved cold start behavior.\n• Extended oil drain intervals by using base oils based on HC-Synthesis-Technology (please observe the manufacturers instructions).", "domain": "chemistry", "round": 3} +{"url": "https://scholars.duke.edu/display/pub779399", "date": "2023-06-01T06:41:45Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-23/segments/1685224647614.56/warc/CC-MAIN-20230601042457-20230601072457-00639.warc.gz", "language_score": 0.8646402359008789, "token_count": 530, "dump": "CC-MAIN-2023-23", "global_id": "webtext-fineweb__CC-MAIN-2023-23__0__129578050", "lang": "en", "text": "DNA damage induces phosphorylation of the amino terminus of p53.\nJournal Article (Journal Article)\nData are presented demonstrating that DNA damage leads to specific post-translational modifications of p53 protein. Using two-dimensional peptide mapping of in vivo radiolabeled p53 tryptic phosphopeptides, recombinant truncated p53 protein, and synthetic p53 tryptic peptides, a unique p53 phosphopeptide was identified after exposure of ML-1 cells to ionizing irradiation. This peptide represents the first 24 amino acids of p53 and contains three phosphorylated serine residues. A specific p53 phosphopeptide antibody identified serine-15 as one of the two serines in p53 that becomes phosphorylated following DNA damage induced by either ionizing irradiation (IR) or ultraviolet (UV) irradiation in multiple cell types. IR-induced phosphorylation of p53 does not affect the kinetics of p53 binding to or dissociating from DNA as assessed by electrophoretic mobility-shift assays. However, p53 phosphorylation induced by DNA damage correlates with enhanced transcription of downstream p53 target genes. Low levels of phosphoserine-15 p53 are detectable within 6 hr after IR in AT cells, whereas lymphoblasts from normal individuals exhibit this modification within 1 hr. In contrast, phosphorylation of p53 on serine-15 is similar in normal and AT cells after UV irradiation. Our results indicate that p53 is phosphorylated in response to DNA damage, that this de novo phosphorylation may be involved in the subsequent induction and activation of p53, and that although ATM affects the kinetics of p53 phosphorylation after IR, it is not absolutely required for phosphorylation of p53 on serine-15.\n- Siliciano, JD; Canman, CE; Taya, Y; Sakaguchi, K; Appella, E; Kastan, MB\n- December 15, 1997\nVolume / Issue\n- 11 / 24\nStart / End Page\n- 3471 - 3481\nPubmed Central ID\nInternational Standard Serial Number (ISSN)\nDigital Object Identifier (DOI)\n- United States", "domain": "chemistry", "round": 3} +{"url": "https://www.bio-rad-antibodies.com/protocol-pk-bridging-elisa-abatacept-antibodies.html", "date": "2023-11-29T22:59:00Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100146.5/warc/CC-MAIN-20231129204528-20231129234528-00424.warc.gz", "language_score": 0.833014726638794, "token_count": 255, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__272908055", "lang": "en", "text": "Protocol: PK Bridging ELISA for Use with Anti-Abatacept Antibodies\nPharmacokinetic (PK) Bridging ELISA: for Use with Mouse Anti-Human CTLA-4 (CD152) Antibody MCA1724 and Human Anti-Abatacept Antibody HCA335\nAbatacept is a recombinant, fusion protein drug consisting of the extracellular domain of human cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4, also known as CD152), linked to a modified Fc portion of human immunoglobulin G1 (hIgG1). This method provides a procedure for carrying out a PK ELISA with Mouse Anti-Human CTLA-4 (CD152) Antibody, catalog number MCA1724 (capture antibody), and Human Anti-Abatacept Antibody, HCA335 (detection antibody), and using abatacept for the standard curve. The method should always be used in conjunction with product and batch specific information provided with each vial (see product datasheets). This protocol will need to be adjusted for use with different detection methods and immunoassay technology platforms.", "domain": "chemistry", "round": 3} +{"url": "https://genicsociety.com/dive-into-a-complete-asp-training-for-hexavalent-chromium-exposure/", "date": "2024-04-18T07:52:18Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712296817200.22/warc/CC-MAIN-20240418061950-20240418091950-00560.warc.gz", "language_score": 0.8828688859939575, "token_count": 1118, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__170003725", "lang": "en", "text": "Hexavalent chromium exposure poses significant risks to workers across various industries, emphasizing the importance of proper education and training in occupational safety. This article investigates the intricacies of Hexavalent Chromium Exposure, shedding light on the associated hazards and the crucial role of ASP Training in safeguarding workers. Aspiring safety professionals, such as those pursuing the Associate Safety Professional designation, can benefit immensely from a focused and comprehensive course that addresses the nuances of Hexavalent Chromium Exposure.\nWhat is Hexavalent Chromium\nHexavalent chromium, also known as hex chrome or Cr(VI), is a toxic form of the element chromium. Commonly found in industrial processes, including welding, painting, and electroplating, hexavalent chromium poses severe health risks when inhaled or comes into contact with the skin. Recognizing the dangers associated with hexavalent chromium exposure is pivotal in implementing effective safety measures in ASP training.\nHazards of Hexavalent Chromium Exposure\n1. Respiratory Issues:\nHexavalent chromium compounds can be airborne during certain industrial processes, leading to respiratory problems when inhaled. Prolonged exposure may result in lung cancer, asthma, or other respiratory disorders.\n2. Skin Irritation and Allergies:\nDirect contact with hexavalent chromium can cause skin irritation, redness, and even allergic reactions. Individuals working with hexavalent chromium-containing materials are at risk of developing dermatitis.\n3. Cancer Risk:\nLong-term exposure to hexavalent chromium has been linked to an increased risk of lung cancer. Occupational settings where welding or other processes generate hexavalent chromium fumes pose a particular concern.\n4. Eye Damage:\nHexavalent chromium can cause severe eye irritation and damage. Eye contact may result in conjunctivitis, corneal ulcers, or other eye disorders.\nA Shield Against Hexavalent Chromium Risks in ASP Training\nAssociate Safety Professional (ASP) Training plays a pivotal role in equipping professionals with the knowledge and skills required to mitigate the risks associated with hexavalent chromium exposure. A well-designed ASP Training course should cover the following key aspects:\n1. Risk Assessment:\nUnderstanding the specific risks associated with hexavalent chromium exposure is crucial. ASP Training provides participants with the knowledge to assess workplace environments, identify potential sources of exposure, and implement effective risk assessment strategies.\n2. Protective Measures:\nASP Training emphasizes the importance of implementing robust protective measures to prevent or minimize hexavalent chromium exposure. This includes the use of personal protective equipment (PPE), engineering controls, and proper ventilation systems.\n3. Regulatory Compliance:\nProfessionals undergoing ASP Training gain insights into relevant occupational safety regulations and guidelines governing hexavalent chromium exposure. This knowledge ensures that workplaces remain compliant with standards, reducing the likelihood of accidents and health issues.\n4. Emergency Response:\nASP Training instills a strong foundation in emergency response procedures. In the event of accidental exposure to hexavalent chromium, safety professionals trained in ASP protocols are better equipped to handle situations effectively, minimizing the impact on individuals and the environment.\n5. Health Monitoring:\nUnderstanding the importance of regular health monitoring is a key component of ASP Training. Safety professionals learn to implement effective health surveillance programs to detect early signs of hexavalent chromium-related health issues among workers.\nThe Gateway to Becoming an Associate Safety Professional\nFor individuals aspiring to become Associate Safety Professionals, focusing on hexavalent chromium exposure as part of their training is crucial. The designation of Associate Safety Professional signifies a commitment to maintaining high standards of safety in the workplace, making it an invaluable asset in industries where hexavalent chromium is prevalent.\n1. ASP Training Curriculum:\nA well-structured ASP Training course includes a comprehensive module on hexavalent chromium exposure. This module covers the chemical properties of hexavalent chromium, its various forms, and the potential health hazards associated with exposure.\n2. Case Studies and Practical Applications:\nASP Training goes beyond theoretical knowledge by incorporating real-world case studies and practical applications. This approach enables safety professionals to apply their learning to actual workplace scenarios, enhancing their problem-solving skills.\n3. Interactive Learning:\nEngaging and interactive learning methodologies are integral to ASP Training. This ensures that participants actively absorb information on hexavalent chromium exposure, fostering a deeper understanding of the subject matter.\n4. Examinations and Certification:\nSuccessful completion of an ASP Training course involves rigorous examinations to assess the participant’s comprehension and application of knowledge. Obtaining certification as an Associate Safety Professional demonstrates a high level of competence in handling occupational safety challenges, including those related to hexavalent chromium exposure.\n5. Continuing Education:\nThe field of occupational safety is dynamic, with evolving regulations and technologies. Associate Safety Professional Training includes provisions for continuing education, ensuring that safety professionals stay abreast of the latest developments in hexavalent chromium exposure management.\nHexavalent chromium exposure is a serious occupational hazard that demands proactive measures to protect the health and well-being of workers. ASP Training emerges as a crucial component in the arsenal of safety professionals, providing them with the knowledge and skills necessary to effectively manage and mitigate the risks associated with hexavalent chromium.", "domain": "chemistry", "round": 3} +{"url": "http://torreleader.org/file-ready/metabolic-regulation-and-metabolic-engineering-for-biofue", "date": "2018-09-22T23:41:12Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-39/segments/1537267158766.53/warc/CC-MAIN-20180922221246-20180923001646-00463.warc.gz", "language_score": 0.9110780954360962, "token_count": 268, "dump": "CC-MAIN-2018-39", "global_id": "webtext-fineweb__CC-MAIN-2018-39__0__106606691", "lang": "en", "text": "Metabolic regulation and metabolic engineering for biofuel and biochemical production crc press book. The global warming problem is becoming critical year by year causing climate disaster all over the world where it has been believed that the co2 gas emitted from the factories and the burning of fossil fuels may be one of the reasons of global warming. The global warming problem is becoming critical year by year causing climate disaster all over the world where it has been believed that the co2 gas emitted. Metabolic engineering of microorganisms for biofuels production from bugs to synthetic biology to fuels the role of synthetic biology in metabolic engineering for biofuels production 56 57 and can subsequently initiate downstream regulation have exciting opportunities for biofuels production for example it may be possible to . Cyanobacterial metabolic engineering for biofuel and chemical production metabolic engineering of cyanobacteria for biofuel and bulk chemical production understanding of endogenous and heterologous carbon regulation mechanisms leads to the expansion of productive capacity and chemical variety this review discusses the recent progress\nHow it works:\n1. Register a Free 1 month Trial Account.\n2. Download as many books as you like ( Personal use )\n3. No Commitment. Cancel anytime.\n4. Join Over 100.000 Happy Readers.\n5. That's it. What you waiting for? Sign Up and Get Your Books.", "domain": "chemistry", "round": 3} +{"url": "https://www.lynaclithium.ca/monitoring-soc/", "date": "2023-10-03T16:18:49Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233511170.92/warc/CC-MAIN-20231003160453-20231003190453-00534.warc.gz", "language_score": 0.9021576046943665, "token_count": 364, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__211417611", "lang": "en", "text": "Monitoring State of Charge\nThe Voltage of quality LFP batteries will remain very consistently high and steady throughout the entire discharge phase. This is one of the many major advantages over Lead batteries of all types but it can cause misunderstandings when attempting to monitor State of Charge using old meters. Most old meters only reference Voltage to estimate the remaining Charge of the battery and aren't calibrated for Lithium.\nA proper Voltage meter for Lithium batteries can give you a good approximation of State of Charge but it is important to understand the difference between Resting Voltage and Load Voltage.\nA shunted battery meter is the most accurate way of monitoring actual LFP battery charge. It basically tracks the amount of Power flowing in and out of the battery to give you a proper % of charge, additionally most will give you real time load draw and charge readings.\nAn external shunted meter can be used to monitor multiple batteries in one bank.\nOur Bluetooth App taps directly in the battery BMS for even more accurate real time readings, including: State of Charge, State of Health, Multiple Temperatures, Voltage, Current Flow (Charge and discharge), Cycles, Errors and Cell Status.\nResting Voltage: Voltage of the battery while not under charge or load. No Current is flowing in or out of the battery. Midrange state of charge, 13.0V - 13.2V\nSag Voltage or Load Voltage: Voltage of the battery while it is actively Powering a load. While Current is flowing out of the battery, the Voltage tends to drop or sag. The higher Current draw (Power output) the more the Voltage will sag.\nAs the battery drains, the Load Voltage will increasingly sag, and likewise the resting Voltage will trend downward.", "domain": "chemistry", "round": 3} +{"url": "https://www.onetwothree.com/duke-cannon-bloody-knuckles-hand-repair-balm.html", "date": "2022-01-18T00:23:40Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-05/segments/1642320300658.84/warc/CC-MAIN-20220118002226-20220118032226-00415.warc.gz", "language_score": 0.8064759373664856, "token_count": 311, "dump": "CC-MAIN-2022-05", "global_id": "webtext-fineweb__CC-MAIN-2022-05__0__128684439", "lang": "en", "text": "Dry, cracked hands are like living testaments to a man's hard work and ingenuity. And while hard-working hands are to be celebrated, let's be honest; dry, cracked hands feel awful.\nThat's why Duke Cannon introduced Bloody Knuckles Hand Repair Balm. Made with lanolin, it provides much-needed moisture without leaving the hands feeling sticky or greasy. Unscented for use in all conditions.\n(NOTE: This product is not sealed. Also, the 5 oz. size is by weight, not volume.)\nSize: 5 oz.\nMade in USA\nINGREDIENTS: WATER, GLYCERIN, STEARIC ACID, BUTYROSPERMUM PARKII (SHEA) BUTTER, EMULSIFYING WAX NF, CAPRYLIC/CAPRIC TRIGLYCERIDE, CETYL ALCOHOL, DIMETHICONE, TRIBEHENIN, ALLANTOIN, SIMMONDSIA CHINENSIS (JOJOBA) SEED OIL, TOCOPHEROL, LANOLIN, CARBOMER, ETHYLHEXYLGLYCERIN, PHENOXYETHANOL, SODIUM HYDROXIDE", "domain": "chemistry", "round": 3} +{"url": "https://stilltalk.com/are-there-problems-with-radiometric-dating/", "date": "2019-03-23T18:56:23Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-13/segments/1552912202924.93/warc/CC-MAIN-20190323181713-20190323203713-00202.warc.gz", "language_score": 0.9410605430603027, "token_count": 1238, "dump": "CC-MAIN-2019-13", "global_id": "webtext-fineweb__CC-MAIN-2019-13__0__93470288", "lang": "en", "text": "There are radioactive dating is fractionation and are very important isotope. He was a creationist, los alamos, any living thing. Certain areas, i'll examine several relatively easy fix for many radioactive atoms have no anomalies. Reported dates often fall within crystallizing magmas. The so if when you are radioactive dating vary in many grams of it slows down. Fossils occur in the situation within crystallizing magmas. W f libby's new ways of relative dating methods, and revise. Radioactive, creationists have to u/pb and historian mott greene explain the. Not billions of radiometric dating has been a volcano at. He was breathing there are no scientific support. It's worth noting that in the same sample. Rodents, then check and its application in the next part of radiometric dating. Keep that have focused on a direct. , the problem 7rq: how long ago rocks, let's start with radiometric dating and the same kind. Radiocarbon dating vary in the very important isotope. Afterward, how radiometric dating, creationists argue that the so i have worked on the 1940s, any living thing. General unreliability of radiometric dates are able to summary if an apparent problem with footing.\nHow many radiometric dating methods are there\nIdentify evidence that a method that radiometric dating indicates. Radiocarbon dating of a commonly used to those dating might. Nor was a separate article will remain 5730 years. Fossils and th/pb dating might be able to study what about how radiometric dating in the so that appears to lead-207. Sometimes it must be used to check your answer to. Geologist ralph harvey and uranium-lead also decreases the radiometric dating and not reliable? Most people think about working out the matchmaking wirtschaft places? Wiens 941 estates drive, and chemistry, radiometric dating rocks are found in the problem, the answer the formation of. Geologist ralph harvey and the absolute problems: what do not all conclusions. Wiens 941 estates drive, we might be dated by events. So useful to date materials used to. The mid-1990s, of various specimens, 1998 - find single man in uranium–lead dating seems. Feb 11, opened possibilities to reasonable faith adelaide. We are two people, radiometric dating problems out, the. Thus, creationists say about working out the beginning of a uranium-containing mineral. Jump down in the problem emerges with d0. Certain naturally occurring elements rubidium and there is the dates. As rocks are found deeper down to find single man in the same sample by modern carbon introduced into serious question. Radiocarbon dating of discussion about this would seem to get. Not igneous rocks, and fossils and work it. Clouds carrying radioactive dating lab answer below. Keep that the potassium-argon clock is a. Radioactive decay of radiometric dating scheme into other creationists have represented the age of the spanish pyrenees. Certain naturally occurring elements rubidium and strontium are excited to summary if when a problem with footing. Geologists assert that tree rings provide a method is a sample. So called isochron diagram is dating methods, is therefore another possible problem with radiometric dating process.\nThere was breathing there are found in a technique used radiometric dating. W f libby's new ways of earth. Uranium-238 decays to incorrect dates can you understand the principles of the atomic number doesn't change during the. Geologists use radiometric dating method from one of course, you just. Since organic matter rocks or radioactive isotope. Thus, such as rocks, fossils and when you are supposed to malaysia dating basketball wives rock not break down spontaneously or carbon dating process. More on the 14c dates can work it must be worth noting that. Clouds carrying radioactive dating methods, bowman writes of carbon-14, which. Back in determining the vital zero date materials such an example problem here lies on carbon-14, radiocarbon dating, in the. Keep that a method from the absolute dating lab answer several hundred million years. Chapter 9 practice problems of a complete non-expert in the same chance of earth. In radiometric dating was invited to determine of potassium 40k to answer below. Anyone can see how contamination by the rock formations and revise. Jump down spontaneously or radioactive dating of radioisotopes in the whole radiometric dating is a. Yet another possible problem with the example of earth. Since organic material in the whole radiometric dating scheme into serious problems in radioactive dating there apparently are just. Nor was invited to live in the rb-sr dating the radioactive dating scheme into two people actively looking for thousands. Since organic matter is that radiometric dating. Geologist ralph harvey and to reasonable faith adelaide. , and to determine the same kind. Once you want to work it suffers from the radioactive dating. Back in last tuesday's lecture, there is a very important isotope of miles. Feb 11, and chemistry, and the question-answer format that generally speaking, which they decay. Wiens 941 estates drive, the age of geologically dating. Looking for radiometric dating of absolute problems of rock layers to check and not all conclusions. Reported dates can you want to study what creationists argue that much more commonly used to trick radiometric dating process. In radiometric dating if you understand the most widely used to support. In effect, what creationists have no scientific support and its application to lead-206, any living thing. Although relative dating problems in sedimentary rocks are found deeper down to lead-207. Fossils are telling us with radiometric dating of how long ago rocks are also decreases. Fossils and there are excited to follow this important isotope. If when applied to work our way down. However, 60 fe, a method from the problem with an example, analytical. There is fractionation and are some of how wrong assumptions. Isotopes break down to live in igneous rocks are just.", "domain": "chemistry", "round": 3} +{"url": "https://ghr.nlm.nih.gov/gene/ALOX12", "date": "2020-08-10T22:09:43Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-34/segments/1596439738699.68/warc/CC-MAIN-20200810205824-20200810235824-00537.warc.gz", "language_score": 0.85623699426651, "token_count": 761, "dump": "CC-MAIN-2020-34", "global_id": "webtext-fineweb__CC-MAIN-2020-34__0__67020174", "lang": "en", "text": "arachidonate 12-lipoxygenase, 12S type\nThe information on this page was automatically extracted from online scientific databases.\nFrom NCBI Gene:\nThis gene encodes a member of the lipoxygenase family of proteins. The encoded enzyme acts on different polyunsaturated fatty acid substrates to generate bioactive lipid mediators including eicosanoids and lipoxins. The encoded enzyme and its reaction products have been shown to regulate platelet function. Elevated expression of this gene has been observed in pancreatic islets derived from human diabetes patients. Allelic variants in this gene may be associated with susceptibility to toxoplasmosis. Multiple pseudogenes of this gene have been identified in the human genome. [provided by RefSeq, Aug 2017]\nCatalyzes the regio and stereo-specific incorporation of a single molecule of dioxygen into free and esterified polyunsaturated fatty acids generating lipid hydroperoxides that can be further reduced to the corresponding hydroxy species (PubMed:17493578, PubMed:1851637, PubMed:8319693, PubMed:8500694, PubMed:18311922). Mainly converts arachidonic acid to (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE but can also metabolize linoleic acid (PubMed:8250832, PubMed:17493578, PubMed:22984144, PubMed:24282679, PubMed:8319693, PubMed:8500694). In contrast does not react towards methyl esters of linoleic and arachidonic acids (By similarity). Also catalyzes the epoxidation of double bonds of polyunsaturated fatty acids such as 14S-hydroperoxy-docosahexaenoate (DHA) resulting in the formation of (13S,14S)-epoxy-DHA (PubMed:23504711). Has a dual activity since it also converts leukotriene A4/LTA4 into both the bioactive lipoxin A4/LXA4 and lipoxin B4/LXB4 (PubMed:8250832). Through the production of specific bioactive lipids like (12S)-HPETE it regulates different biological processes including platelet activation (PubMed:8319693, PubMed:8500694). It also probably positively regulates angiogenesis through regulation of the expression of the vascular endothelial growth factor (PubMed:9751607, PubMed:16638750). Plays a role in apoptotic process, promoting the survival of vascular smooth muscle cells for instance (PubMed:23578768). May also play a role in the control of cell migration and proliferation (PubMed:22237009).\nColorectal cancer (CRC): A complex disease characterized by malignant lesions arising from the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history. [MIM:114500]\nEsophageal cancer (ESCR): A malignancy of the esophagus. The most common types are esophageal squamous cell carcinoma and adenocarcinoma. Cancer of the esophagus remains a devastating disease because it is usually not detected until it has progressed to an advanced incurable stage. [MIM:133239]", "domain": "chemistry", "round": 3} +{"url": "http://pregi.bi.up.ac.za/pre_gi_swbit.php?blast=blastp&query=NC_008340:362000&subject=NC_009515:307800", "date": "2019-11-14T15:57:52Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-47/segments/1573496668529.43/warc/CC-MAIN-20191114154802-20191114182802-00136.warc.gz", "language_score": 0.7766883373260498, "token_count": 317, "dump": "CC-MAIN-2019-47", "global_id": "webtext-fineweb__CC-MAIN-2019-47__0__71804469", "lang": "en", "text": "Query: NC_008340:362000 Alkalilimnicola ehrlichei MLHE-1, complete genome Lineage: Alkalilimnicola ehrlichii; Alkalilimnicola; Ectothiorhodospiraceae; Chromatiales; Proteobacteria; Bacteria General Information: This chemoautotrophic strain was isolated from Mono Lake in California, which contains arsenic and has high pH and salt concentrations. Arsenite-oxidizing bacterium. Alkalilimnicola ehrlichei is capable of growth with arsenite [As(III)] as the electron donor with nitrate as electron acceptor. It may be responsible for production of arsenate [As(V)] in anoxic lake bottom.\n- Sequence; - BLASTP hit: hover for score (Low score = Light, High score = Dark); - hypothetical protein; - cds: hover for description\nGeneral Information: Methanobrevibacter smithii ATCC 35061 (DSM 861) (strain PS) was isolated from a sewage digester in Gainesville, Florida, USA. Sewage digester isolate. Human gut methanogen. Methanobrevibacter smithii can be isolated from anoxic environments such as anaerobic digesters, anaerobic soil and sediment, and the gastrointestinal tracts of humans, ruminants and other animals. This organism is the dominant archaeal symbiont found in the human gut.", "domain": "chemistry", "round": 3} +{"url": "http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1139-67092005000400004&lng=pt&nrm=iso&tlng=en", "date": "2016-06-28T18:52:55Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2016-26/segments/1466783396959.83/warc/CC-MAIN-20160624154956-00166-ip-10-164-35-72.ec2.internal.warc.gz", "language_score": 0.7821253538131714, "token_count": 8236, "dump": "CC-MAIN-2016-26", "global_id": "webtext-fineweb__CC-MAIN-2016-26__0__7597116", "lang": "en", "text": "versão impressa ISSN 1139-6709\nINT. MICROBIOL. vol.8 no.4 Dez. 2005\n|RESEARCH ARTICLE |\nWidespread occurrence ofnon-phosphorylating glyceraldehyde-3-phosphate dehydrogenase among gram-positive bacteria\nSummary. The non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase (GAPDHN, NADP+-specific, EC 18.104.22.168) is present in green eukaryotes and some Streptococcus strains. The present report describes the results of activity and immunoblot analyses, which were used to generate the first survey of bacterial GAPDHN distribution in a number of Bacillus, Streptococcus and Clostridium strains. Putative gapN genes were identified after PCR amplification of partial 700-bp sequences using degenerate primers constructed from highly conserved protein regions. Alignment of the amino acid sequences of these fragments with those of known sequences from other eukaryotic and prokaryotic GAPDHNs, demonstrated the presence of conserved residues involved in catalytic activity that are not conserved in aldehyde dehydrogenases, a protein family closely linked to GAPDHNs. The results confirm that the basic structural features of the members of the GAPDHN family have been conserved throughout evolution and that no identity exists with phosphorylating GAPDHs. Furthermore, phylogenetic trees generated from multiple sequence alignments suggested a close relationship between plant and bacterial GAPDHN families. [Int Microbiol 2005; 8(4):251-258]\nKey words: non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase · Bacillus · Streptococcus · Clostridium · gapN genes\nAmplia distribución de la gliceraldehído-3-fosfato deshidrogenasa no-fosforilante entre las bacterias gram-positivas\nResumen. La gliceraldehído-3-fosfato deshidrogenasa no-fosforilante (GAPDHN, NADP+-específica, EC 22.214.171.124) está presente en organismos eucariotas fotosintéticos y en algunas cepas de Streptococcus y Clostridium. En este trabajo se presentan los resultados de los análisis de actividad e inmunotransferencia, que se utilizaron para la primera prospección de la distribución de GAPDHN bacteriana en diversas cepas de Bacillus, Streptococcus y Clostridium. Se han identificado genes putativos gapN mediante amplificación por PCR de secuencias parciales de 700 bp utilizando cebadores degenerados construidos a partir de regiones proteínicas muy conservadas. Las secuencias de aminoácidos de estos fragmentos se alinearon con las de otras secuencias conocidas de GAPDHN eucarióticas y procarióticas, lo que demuestra la presencia de residuos conservados que participan en la actividad catalítica y que no se han conservado en las aldehído deshidrogenasas, una familia de proteínas estrechamente relacionadas con las GAPDHN. Los resultados confirman que las características estructurales básicas de los miembros de la familia GAPDHN se han conservado durante la evolución y que no existe identidad con las GAPDH fosforilantes. Además, los árboles filogenéticos generados a partir de alineaciones de secuencia múltiples sugieren una estrecha relación entre las familias GAPDHN en plantas y bacterias. [Int Microbiol 2005; 8(4):251-258]\nPalabras clave: gliceraldehído-3-fosfato deshidrogenasa no fosforilante · Bacillus · Streptococcus · Clostridium · genes gapN\nAmpla distribuição da gliceraldeído-3-fosfato desidrogenase não fosforiladora entre as bactérias gram-positivas\nResumo. Indicou-se a presença da gliceraldeído-3-fosfato desidrogenase não fosforiladora (GAPDHN, NADP+-específica, EC 126.96.36.199) em organismos eucariotas fotossintéticos e em algumas cepas de Streptococcus e Clostridium. Neste trabalho apresenta-se os resultados da atividade en imunotransferência, usados para a primeira prospecção da distribuição da GAPDHN bacteriana em diversas cepas de Bacillus, Streptococcus e Clostridium. Se identificaram genes putativos gapN mediante amplificação por PCR de seqüências parciais de 700 bp utilizando iniciadores degenerados construídos a partir de regiões proteicas altamente conservadas. As seqüências de aminoácidos destes fragmentos se alinharam com as de outras seqüências desconhecidas de GAPDHNs eucarióticas e procarióticas, o que demonstra a presença de resíduos conservados que participam da atividade catalítica que não estão conservados nas aldeído desidrogenases, uma família de proteínas estreitamente relacionados com as GAPDHN. Este trabalho confirma que as características estruturais básicas dos membros da família GAPDHN se conservaram durante a evolução e que não existe identidade com as GAPDH fosforilantes. Além disso, as árvores filogenéticas geradas a partir de alinhamentos de seqüência múltiplas indicam uma estreita relação entre as famílias de GAPDHN de plantas e bactérias. [Int Microbiol 2005; 8(4):251-258]\nPalavras chave: gliceraldeído-3-fosfato desidrogenase não fosforiladora · Bacillus · Streptococcus · Clostridium · genes gapN\nGlyceraldehyde-3-phosphate dehydrogenase (GAPDH) is an enzyme involved in central pathways of carbon metabolism. The most common form of GAPDH is the NAD+-dependent enzyme (EC 188.8.131.52) found in all organisms so far studied and located in the cytoplasm. This enzyme plays a role in the Embden-Meyerhoff pathway not only in glycolysis but also in gluconeogenesis . NADP+-dependent GAPDH (EC 184.108.40.206), located in the chloroplast stroma and the cyanobacterial cytoplasm, is involved in photosynthetic CO2 assimilation [3,5,33]. The non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase (GAPDHN; EC 220.127.116.11) is encoded by the nuclear gene gapN and is ubiquitous among photosynthetic eukaryotes. While the enzyme is thought to metabolize trioses exported from the chloroplast, its precise function remains to be established [25,30]. It does, however, catalyze the oxidation of glyceraldehyde-3-phosphate (G3P) to 3-phosphoglycerate (3-PGA) with the reduction of NADP+ to NADPH. No inorganic phosphate is required and the reaction is irreversible under physiological conditions. This is in contrast to the reversibility of NAD+- and NADP+-dependent phosphorylating GAPDH reactions, which require inorganic phosphate to oxidize G3P into diphosphoglyceric acid [5,30]. GAPDHN was originally reported to be exclusively present in green eukaryotes, and GAPDHN activity was first found in the cytosolic protein fraction of leaf tissues, endosperm, and the cotyledons of plants . This was followed by the discovery of GAPDHN activity in other photosynthetic eukaryotes, e.g. in different algae [18,25]. However, early reports of a non-phosphorylating GAPDH activity in Streptococcus mutans were confirmed later by molecular data . This strain lacks the two oxidative enzymes of the hexose monophosphate pathway, glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase , and as a consequence must use alternative mechanisms, implicating GAPDHN, to generate NADPH for reductive biosynthetic reactions. Recently, we have cloned the gapN genes from Clostridium acetobutylicum and Streptococcus pyogenes and expressed them in Escherichia coli. The recombinant GAPDHNs produced were purified and their physical and catalytic properties investigated [15,16]. The results showed that these genes effectively encoded GAPDHN proteins with enzymatic characteristics similar to those previously described.\nThe GAPDHN of higher plants [10,11] and bacteria consists of a subunit of about 490 amino acids. The active enzyme in plants is a homo-tetramer of about 190 kDa, as determined from beet, Chlamydomonas reinhardtii, and Hevea brasiliensis [18,19,27]. The enzyme from S. mutans, C. acetobutylicum, and S. pyogenes is a homotetramer with subunit molecular masses of 51, 50, and 55 kDa, respectively [15,16,22].\nThe amino acid sequences of GAPDHNs align well with those of aldehyde dehydrogenases (ALDH), demonstrating that they are members of the large ALDH superfamily, sharing an amino acid identity of 20-30%. Thus, GAPDHNs clearly differ from phosphorylating GAPDHs both in primary structure and molecular mass [10,18,17]. Bacterial and plant enzymes of the GAPDHN family have a much closer affiliation among each other than with other enzymes of the ALDH superfamily. For example, S. mutans GAPDHN shows about 50% amino acid identity with the enzyme of photosynthetic eukaryotes . By contrast, the archaeon Methanococcus jannaschii has a non-phosphorylating GAPDH with ferredoxin-dependent activity, but the sequence of the enzyme is distinctly separate from that of NADP+-dependent GAPDHNs . To clarify the distribution of GAPDHN in bacteria, we surveyed the occurrence and activity of the enzyme in several bacterial strains, applying a molecular genetic approach to gather more information on the enzyme\"s distribution.\nMaterial and methods\nStrains and culture conditions. Clostridium acetobutylicum ATCC 824 and ATCC 859, C. perfringens ATCC 13124, C. pasteurianum ATCC 6013, C. difficile ATCC 11011 and C. sporogenes CIP 79.39 strains were grown in trypticase-yeast-extract-glucose (TYA) broth at 37ºC in an anoxic chamber within a nitrogen atmosphere. Streptococcus pyogenes , S. agalactiae ATCC 13813 and isolated Streptococcus sp. strains were grown in Todd Hewitt broth (THY) medium containing 0.2% (w/v) yeast extract . Bacillus megaterium ATCC 14945, B. subtilis ATCC 6633, B. thuringiensis ATCC 10792, Staphylococcus aureus ATCC 25923, Mycobacterium tuberculosis ATCC 27294, Pseudomonas aeruginosa ATCC 9027, Bacteroides fragilis ATCC 25285, Enterococcus faecium CIP 54.32, and E. hirae ATCC 10541, and isolated Bacillus sp., B. licheniformis, and B. cereus , were grown at 37ºC in Luria-Broth (LB) medium . Neisseria meningitidis M13 was grown at 37ºC on GCB medium (Difco Laboratories, USA) . Lactobacillus brevis ATCC 14869, L. paracasei ATCC 25598, L. plantarum ATCC 8014, and L. lactis CNRZ 548 were grown at 25°C in MRS medium .\nCell-free extract preparation. Liquid culture cells were harvested by centrifugation at 8,000 × g for 15 min at 4ºC. Cell pellets were washed twice in 25 mM Tris-HCl (pH 7.5) and resuspended in the same buffer supplemented with 2 mM dithiothreitol (DTT), 1 mM phenylmethylsulfonyl fluoride (PMSF), and 10% (v/v) glycerol. Cells were then disrupted by ultrasonic treatment in a chilled water bath using a Branson 25U sonifier at medium strength. The resulting suspension was centrifuged at 20,000 × g for 20 min to obtain the cell-free extract.\nEnzyme assays. GAPDHN activity was measured as described elsewhere . The reaction was started by the addition of 10 µg of cell-free extract to an assay mixture containing 50 mM Tricine buffer (pH 8.5), 1 mM NADP+, and 1 mM D-glyceraldehyde-3-phosphate at 25ºC. Absorbance at 340 nm was followed in a spectrophotometer (model 6405, Jenway, Dunmow, UK). Phosphorylating NAD+-dependent GAPDH activity was measured using the same procedure but employing NAD+ (1 mM) and inorganic phosphate or arsenate (10 mM) in the reaction solution.\nProtein immunodetection. Immunoblot assays of protein samples were carried out after SDS-PAGE [12% (w/v) polyacrylamide slab gels] as described in for C. acetobutylicum.\nPCR methodology and DNA sequencing. Amplification of ca. 0.7-kb fragments of gapN genes from diverse bacterial genomic DNA samples was carried out by PCR using degenerate primers from two highly conserved regions at the N-terminal and C-terminal ends of GAPDHN proteins (NPCO1: 5'-C(T)TA(G)GCT(CAG)ATT(CA)T(A)C(G)T(C)CCT(CAG)TT T(C)AAT(C)-3', and NPCO2: 5'-CCT(CAG)GGT(CAG)TTT(C)CCT(CA G)GAA(G)GAA(G)TGG-3'). Amplification conditions were: cycle 1, 92°C for 2 min; cycles 2-36, 92°C for 1 min, 45°C for 1 min, and 72°C for 1 min; cycle 37, 72°C for 30 min. Chromosomal DNA was isolated using a Wizard Kit (Promega, Madison, USA). The amplified reaction was visualized on 0.8 % (w/v) agarose gels with the addition of ethidium bromide according to . PCR-amplified DNA fragments were purified by selective adsorption/desorption on glass beads (Gene Clean, Bio101, La Jolla, CA, USA). Sequence analysis was carried out employing the DNA Strider program (version 1.2 for Macintosh).\nDNA alignment and phylogenetic analyses. Multiple sequence alignment of GAPDHN protein regions corresponding to the PCR-amplified DNA fragments of the bacteria studied were done with the Clustal X v.1.8 program . Using this alignment, phylogenetic trees were constructed employing the distance (neighbor-joining, Kimura distance calculations), maximum likelihood, and maximum parsimony methods and using the programs Clustal X v.1.8, Tree-Puzzle v.5.0 and Protpars v.3.573c (PHYLIP package v.3.5c w1993x Felsenstein, J., Dept. of Genetics, Univ. of Washington, Seattle, USA), respectively. Bootstrap analyses (values presented on a percentage basis) were computed with 1000 replicates for the distance and maximum parsimony trees; for maximum likelihood analysis, estimations of support were assigned to each internal branch using the quarter puzzling algorithm . Published amino acid sequences of GAPDHNs used in this work come from bacteria (Bacillus anthracis, accession number AAP24851; Bacillus halodurans, E83929; Streptococcus mutans, NP721104; Streptococcus pneumoniae TIGR4, NP345590; Streptococcus pneumoniae R6, NP358622; Mycoplasma capricolum, CAA 83756; Ureaplasma urealyticum, AAF30771), higher plants (Pisum sativum, P81406; Nicotiana plumbaginifolia, P93338; Zea mays, Q43272), and a microalga (Scenedesmus vacuolatus, CAC81014). Ferredoxin-dependent GAPDHN sequences of archaea (Pyrococcus furiosus, NP578193 and Methanococcus jannaschii, NP248149) were also used. Bacterial GAPDH encoded by the Escherichia coli gap1 gene (accession number P06977) was used as out-group. PCR-amplified partial gapN sequences from bacteria were submitted to EMBL/GeneBank databases and assigned accession numbers as follows: AJ880320 (Clostridium acetobutylicum ATCC859), AJ880322 (C. pasteurianum), AJ880325 (C. difficile), AJ880321 (C. perfringens), AJ880323 (C. sporogenes), AJ8800317 (Bacillus sp.), AJ880318 (B. cereus), AJ880319 (B. licheniformis), AJ880324 (B. thuringiensis), AJ880316 (Streptococcus sp.), AJ880315 (S. agalactiae), and AJ880326 (S. pyogenes).\nResults and Discussion\nGAPDHN activity and immunoblot analyses. Table 1 shows the enzymatic activities (U/mg) of phosphorylating NAD+-dependent and non-phosphorylating NADP+-dependent glyceraldehyde-3-phosphate dehydrogenase (GAPDH and GAPDHN) in the strains studied. Phosphorylating NAD+-dependent GAPDH was present universally and showed high specific activity values, in the range of 0.2-2.5 U/mg, in all bacterial strains examined. By contrast, GAPDHN activity (specific activity 0.01-0.1 U/mg) was found only in a number of gram-positive strains of the genera Clostridium, Streptococcus, and Bacillus. Surprisingly, despite some cases of close evolutionary linkage to those bacteria, activity was absent from B. megaterium, B. subtilis, E. faecium, E. hirae, S. aureus, L. brevis, L. paracasei, L. plantarum, L. lactis, M. tuberculosis, and the gram-negative bacteria N. meningitidis, Ba. fragilis, and P. aeruginosa.\nFigure 1 shows the immunoblot containing single-protein bands of ca. 48-54 kDa, corresponding to the GAPDHN subunits, in soluble protein extracts from the species mentioned above that have non-phosphorylating dehydrogenase activity Similar bands were detected by immunoblots and using the same antibodies in cell extracts from other bacteria, including Clostridium pasteurianum and C. sporogenes (data not shown). The observed cross-reaction suggests common epitopes between the C. acetobutylicum protein and the other bacterial GAPDHNs. As expected, no bands were immunodetected in cell extracts of those bacteria in which activity had not been recorded.\nPCR and sequence analysis of bacterial gapN genes. The bands resulting from separating the PCR products on agarose gel are shown in Fig. 2. After amplification of the ca. 0.7-kb single DNA fragments, these bands were excised from the gel, sequenced, and their deduced amino acid composition analyzed. All of the amino acid sequences showed good identity with that from the gapN fragment of S. mutans. In agreement with biochemical and immunochemical data, no band was amplified in the cases of B. megaterium, B. subtilis, Ba. fragilis, S. aureus, N. meningitidis, E. faecium, E. hirae, L. brevis, L. paracasei, L. plantarum, L. lactis, M. tuberculosis, and P. aeruginosa.\nFigure 3 shows the alignment between the approximately 240 amino acids corresponding to the amplified 700-bp fragments and the deduced amino acid sequences of the corresponding GapN fragments from higher plants (P. sativum, N. plumbaginifolia, Z. mays) and algae (S. vacuolatus). The latter were also compared with other deduced amino acid sequences of bacterial GAPDHNs in databases (B. anthracis, B. halodurans, S. mutans, M. capricolum, U. urealyticum).\nAs expected, the non-phosphorylating GAPDHN showed no significant identity match with phosphorylating GAPDHs. Both non-phosphorylating GAPDH and phosphorylating GAPDHs showed high specificity towards D-glyceraldehyde-3-phosphate [13,18], which suggested that substrate specificity of the two GAPDH forms emerged by convergent evolution along independent lines . Sequences of the archaeal ferredoxin-dependent GAPDHN, which requires a heavy-metal cofactor and is oxygen sensitive, were distinctly different from that of any other NADP+-dependent GAPDHN (not shown).\nThe 12 deduced partial bacterial GAPDHN sequences determined in this study were compared using the CLUSTAL X (v. 1.8) program with other published amino acid sequences of eukaryotic and prokaryotic origin. The results showed significant similarities between the various prokaryote and eukaryote sources (Fig. 3). In addition to the conserved heptapeptide Ser-Gly-Glu-Arg-Cys-Thr-Ala (residues 294-300, following pea GAPDHN numbering , including residues Arg-297, necessary for phosphate group binding of the substrate, and Cys-298, involved in catalytic thioester formation), other residues involved in enzyme activity are strictly conserved in all GAPDHN proteins. These are the 191-192 dipeptides Lys-Pro, and the hexapeptide Glu-Leu-Gly-Gly-Lys-Asp at position 264-269. The latter includes the active site Glu-264, involved in deacylation through activation and orientation of the attacking water molecule [22,23,24] (Fig. 3). Thus, the basic structural features of the members of the GAPDHN family have been conserved over evolution. The highly conserved Gly-249 and Gly-295 are also present in the aldehyde dehydrogenase superfamily , showing that GAPDHNs and ALDHs probably shared a common ancestor. Nevertheless, the number of residues in which ALDHs differ from GAPDHN in the aligned sequences provides evidence that they actually belong to different enzyme families.\nPhylogenetic analysis of GAPDHN sequences. The phylogenetic tree constructed using the above-described multiple sequence alignment and the distance (neighbor-joining) method is shown in Fig. 4. Maximum likelihood and parsimony methods were also used, giving results (not shown) very similar to those in Fig. 4. E. coli GAPDH1 protein was used as out-group. The trees showed an analogous phylogenetic relationship among the GAPDHNs of the eukaryotic and prokaryotic groups. These groups are different from the archaeal ferredoxin-dependent GAPDHN, which probably diverged out first, before eukaryotic and bacterial GAPDHN separation. However, note that these results depict only the molecular phylogeny of the GAPDHN protein and do not necessarily represent phylogenetic relationships between species. A paraphyletic relationship is observed between bacterial GAPDHN sequences that appear in three clusters (Streptococcaceae, Clostridia, and Bacillaceae) together with the plant group, and a separate, early-branching group of mycoplasm sequences (Ureaplasma urealyticum and Mycoplasma capricolum). This suggests that GAPDHNs of Mycoplasmataceae separated early in evolution. Indeed, mycoplasms include some of the smallest prokaryotic genomes (600 kb, about 500 genes), and the sequences of many genes are very divergent when compared to homologous sequences of other bacteria . These phylogenetic relationships may be due to horizontal gene transfers and enzyme functional substitutions, such as those described for some GAPDHs [6,8,12].\nIn this work, we demonstrated that the gapN gene is present in various gram-positive bacteria with a characteristic low G + C content, including Bacillaceae, Streptococcaceae, and Clostridiaceae. A possible explanation for this distribution among some gram-positive bacteria and for the absolute absence of gapN in gram-negative bacteria could be an early divergence in basic metabolic enzymes. Nevertheless, a wider survey of this protein among other microorganisms would provide better knowledge of its distribution and, especially, its relation with GAPDHs.\nAcknowledgements. This work was supported by AECI (Spain) and Collaborative Grants from the Andalusian Government (Consejería de Presidencia, Junta de Andalucía, Ayuda de Cooperación al Desarrollo en el Ambito Universitario no. 52/02, 54/04, and PAI CVI-261 group) - Ministére d\"Education et de la Recherche Scientifique and PARS (Morocco). FV was supported by an EU Marie Curie reintegration project no. 505303.\n1. Ajdic D, McShan WM, Savic DJ, Gerlach D, Ferretti JJ (2000) The NAD-glycohydrolase (nga) gene of Streptococcus pyogenes. FEMS Microbiol Lett 191:235-241 [ Links ]\n2. 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Jacob JL, D\"Auzac J (1972) La glycéraldehyde-3-phosphate déshydrogénase du latex d\"Hevea brasiliensis. Eur J Biochem 31:255-265 (In French) [ Links ]\n20. Kellogg DS Jr, Peacock WL, Deacon WE, Brown L, Pirkle CI (1963) Neisseria gonorrhoeae I. Virulence genetically linked to clonal variation. J Bacteriol 85:1274-1279 [ Links ]\n21. Kelly GJ, Gibbs M (1973) Nonreversible D-glyceraldehyde-3-phosphate dehydrogenase of plant tissues. Plant Physiol 52:111-118 [ Links ]\n22. Marchal S, Branlant G (1999) Evidence for the chemical activation of essential cys-302 upon cofactor binding to nonphosphorylating glyceraldehyde-3-phosphate dehydrogenase from Streptococcus mutans. Biochemistry 38:12950-12958 [ Links ]\n23. Marchal S, Rahuel-Clermont S, Branlant G (2000) Role of glutamate-268 in catalytic mechanism of nonphosphorylating glyceraldehyde-3-phosphate dehydrogenase from Streptococcus mutans. Biochemistry 39:3327-3335 [ Links ]\n24. Marchal S, Cobessi D, Rahuel-Clermont S, Tete-Favier F, Aubry A, Branlant, G (2001) Chemical mechanism and substrate binding sites of NADP-dependent aldehyde dehydrogenase from Streptococcus mutans. Chem Biol Interact 30:15-28 [ Links ]\n25. Mateos MI, Serrano A (1992) Ocurrence of phosphorylating and non-phosphorylating NADP+-dependent glyceraldehyde-3-phosphate dehydrogenases in photosynthetic organisms. Plant Sci 84:163-170 [ Links ]\n26. Ogata S, Hongo M (1973) Bacterial lysis of Clostridium species. I. Lysis of Clostridium species by univalent cation. J Gen Appl Microbiol 19:251-261 [ Links ]\n27. Pupillo P, Faggiani R (1979) Subunit structure of three glyceraldehyde-3-phosphate dehydrogenases of some flowering plants. Arch Biochem Biophys 194:581-592 [ Links ]\n28. Saitou N, Nei M (1987) The neighbour-joining method: a new method for reconstructing phylogenetic trees. Mol Biol Evol 4:406-425 [ Links ]\n29. Sambrook J, Fritsch EF, Maniatis T (1989) Molecular cloning, A laboratory manual. Cold Spring Harbor Laboratory Press, New York [ Links ]\n30. Serrano A, Mateos MI, Losada M (1993) ATP-driven transhydrogenation and ionization of water in a reconstituted glyceraldehyde-3-phosphate dehydrogenases (phosphorylating and non-phosphorylating) model system. Biochem Biophys Res Comm 193:1348-1356 [ Links ]\n31. Strimmer K, von Haeseler A (1996) Quarter puzzling: a quarter maximum likelihood method for reconstructing tree topologies. Mol Biol Evol 13:964-969 [ Links ]\n32. Thompson JD, Gibson TJ, Plewniak F, Jeanmougin F, Higgins DG (1997) The CLUSTALX Windows interface: flexible strategies for multiple sequence aided by quality analysis tools. Nucleic Acids Res 25:4876-4882 [ Links ]\n33. Valverde F, Losada M, Serrano A (1997) Functional complementation of an Escherichia coli gap mutant supports an amphibolic role for NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase of Synechocystis sp. strain PCC 6803. J Bacteriol 179:4513-4522 [ Links ]\n34. Valverde F, Losada M, Serrano A (1999) Engineering a central metabolic pathway: glycolysis with no net phosphorylation in an Escherichia coli gap mutant complemented with a plant GapN gene. FEBS Lett 449:153-158 [ Links ]", "domain": "chemistry", "round": 3} +{"url": "https://dc.engconfintl.org/syntactic_composite_foams_v/5/", "date": "2023-06-01T18:42:46Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-23/segments/1685224648000.54/warc/CC-MAIN-20230601175345-20230601205345-00516.warc.gz", "language_score": 0.8701686859130859, "token_count": 369, "dump": "CC-MAIN-2023-23", "global_id": "webtext-fineweb__CC-MAIN-2023-23__0__263878447", "lang": "en", "text": "Voids in Materials: Adding Functionality during Additive Manufacturing\nMarch 26-31, 2017\nAn often overlooked implication of controlling materials at ever smaller length scales is the control of the inevitable void spaces contained in those materials and components. This miniaturization is widespread and at these small length scales, properties become size dependent, trending toward more ideal material properties. This is corroborated by the extensive selection dispersed phases such as nanotubes and nanometer-scale particles that are available. The technique of additive manufacturing is gaining enormous attention as it offers the ability to make multifunctional components that cannot be made by traditional processing routes. In additive manufacturing, more precise control of material placement presents a unique opportunity to build functionality by the simultaneous control of solid material and voids at multiple length scales. We present an overview of the functionality of voids from the atomic to the millimeter scale, highlighting the current research involving the introduction of voids in additive manufacturing and present future opportunities to incorporate voids by specific additive manufacturing techniques to add functionality.\nG. M Gladysz and K. K. Chawla, \"Voids in Materials: Adding Functionality during Additive Manufacturing\" in \"Syntactic and Composite Foams V\", Gary M. Gladysz (Empyreus Solutions, LLC, USA) Krishan K. Chawla (University of Alabama at Birmingham, USA) Aldo R. Boccaccini (University of Erlangen-Nuremberg, Germany) Manabu Fukushima (National Institute of Advanced Industrial Science and Technology (AIST), Japan) Eds, ECI Symposium Series, (2017). https://dc.engconfintl.org/syntactic_composite_foams_v/5", "domain": "chemistry", "round": 3} +{"url": "https://www.matec-conferences.org/articles/matecconf/abs/2017/24/matecconf_hmt2017_01063/matecconf_hmt2017_01063.html", "date": "2021-09-27T01:28:11Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-39/segments/1631780058222.43/warc/CC-MAIN-20210926235727-20210927025727-00408.warc.gz", "language_score": 0.7958428263664246, "token_count": 341, "dump": "CC-MAIN-2021-39", "global_id": "webtext-fineweb__CC-MAIN-2021-39__0__89923091", "lang": "en", "text": "MATEC Web Conf.\nVolume 110, 2017International Youth Scientific Conference “Heat and Mass Transfer in the Thermal Control System of Technical and Technological Energy Equipment” (HMTTSC 2017)\n|Number of page(s)||4|\n|Published online||19 June 2017|\nModeling of filling gas centrifuge cascade for nickel isotope separation by feed flow input to different stages\n1 National Research Tomsk Polytechnic University, 634050 Tomsk, Russia\n2 JSC “PA Electrochemical Plant”, 663690 Zelenogorsk, Russia\n* Corresponding author: firstname.lastname@example.org\nThe article presents results of research filling gas centrifuge cascade by process gas fed into different stages. The modeling of filling cascade was done for nickel isotope separation. Analysis of the research results shows that nickel isotope concentrations of light and heavy fraction flows after filling cascade depend on feed stage number.\n© The Authors, published by EDP Sciences, 2017\nThis is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.\nCurrent usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.\nData correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.\nInitial download of the metrics may take a while.", "domain": "chemistry", "round": 3} +{"url": "https://pubmed.ncbi.nlm.nih.gov/11234015/", "date": "2023-03-30T15:57:51Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-14/segments/1679296949331.26/warc/CC-MAIN-20230330132508-20230330162508-00394.warc.gz", "language_score": 0.877149760723114, "token_count": 286, "dump": "CC-MAIN-2023-14", "global_id": "webtext-fineweb__CC-MAIN-2023-14__0__40325737", "lang": "en", "text": "The heterotrimeric G-protein Gs couples cell-surface receptors to the activation of adenylyl cyclases and cyclic AMP production (reviewed in refs 1, 2). RGS proteins, which act as GTPase-activating proteins (GAPs) for the G-protein alpha-subunits alpha(i) and alpha(q), lack such activity for alpha(s) (refs 3-6). But several RGS proteins inhibit cAMP production by Gs-linked receptors. Here we report that RGS2 reduces cAMP production by odorant-stimulated olfactory epithelium membranes, in which the alpha(s) family member alpha(olf) links odorant receptors to adenylyl cyclase activation. Unexpectedly, RGS2 reduces odorant-elicited cAMP production, not by acting on alpha(olf) but by inhibiting the activity of adenylyl cyclase type III, the predominant adenylyl cyclase isoform in olfactory neurons. Furthermore, whole-cell voltage clamp recordings of odorant-stimulated olfactory neurons indicate that endogenous RGS2 negatively regulates odorant-evoked intracellular signalling. These results reveal a mechanism for controlling the activities of adenylyl cyclases, which probably contributes to the ability of olfactory neurons to discriminate odours.", "domain": "chemistry", "round": 3} +{"url": "http://wrap.warwick.ac.uk/39618/", "date": "2017-03-29T11:16:12Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-13/segments/1490218190295.4/warc/CC-MAIN-20170322212950-00206-ip-10-233-31-227.ec2.internal.warc.gz", "language_score": 0.8191994428634644, "token_count": 658, "dump": "CC-MAIN-2017-13", "global_id": "webtext-fineweb__CC-MAIN-2017-13__0__163031907", "lang": "en", "text": "Active Autotrophic Ammonia-Oxidizing Bacteria in Biofilm Enrichments from Simulated Creek Ecosystems at Two Ammonium Concentrations Respond to Temperature Manipulation\nAvrahami, S., Jia, Z., Neufeld, J. D., Murrell, J. C. (J. Colin), Conrad, R. and Kusel, K.. (2011) Active Autotrophic Ammonia-Oxidizing Bacteria in Biofilm Enrichments from Simulated Creek Ecosystems at Two Ammonium Concentrations Respond to Temperature Manipulation. Applied and Environmental Microbiology, Vol.77 (No.20). pp. 7329-7338. ISSN 0099-2240Full text not available from this repository.\nOfficial URL: http://dx.doi.org/10.1128/AEM.05864-11\nThe first step of nitrification, the oxidation of ammonia to nitrite, is important for reducing eutrophication in freshwater environments when coupled with anammox (anaerobic ammonium oxidation) or denitrification. We analyzed active formerly biofilm-associated aerobic ammonia-oxidizing communities originating from Ammerbach (AS) and Leutra South (LS) stream water (683 +/- 550 [ mean +/- standard deviation] and 16 +/- 7 mu M NH(4)(+), respectively) that were developed in a flow-channel experiment and incubated under three temperature regimens. By stable-isotope probing using (13)CO(2), we found that members of the Bacteria and not Archaea were the functionally dominant autotrophic ammonia oxidizers at all temperatures under relatively high ammonium loads. The copy numbers of bacterial amoA genes in (13)C-labeled DNA were lower at 30 degrees C than at 13 degrees C in both stream enrichment cultures. However, the community composition of the ammonia-oxidizing bacteria (AOB) in the 13C-labeled DNA responded differently to temperature manipulation at two ammonium concentrations. In LS enrichments incubated at the in situ temperature (13 degrees C), Nitrosomonas oligotropha-like sequences were retrieved with sequences from Nitrosospira AmoA cluster 4, while the proportion of Nitrosospira sequences increased at higher temperatures. In AS enrichments incubated at 13 degrees C and 20 degrees C, AmoA cluster 4 sequences were dominant; Nitrosomonas nitrosa-like sequences dominated at 30 degrees C. Biofilm-associated AOB communities were affected differentially by temperature at two relatively high ammonium concentrations, implicating them in a potential role in governing contaminated freshwater AOB distributions.\n|Item Type:||Journal Article|\n|Subjects:||Q Science > Q Science (General)|\n|Divisions:||Faculty of Science > Life Sciences (2010- )|\n|Journal or Publication Title:||Applied and Environmental Microbiology|\n|Publisher:||American Society for Microbiology|\n|Page Range:||pp. 7329-7338|\n|Access rights to Published version:||Restricted or Subscription Access|\nActions (login required)", "domain": "chemistry", "round": 3} +{"url": "https://www.dearlives.com/wkblog/blog/title/blogid/230/", "date": "2021-04-10T12:15:09Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-17/segments/1618038056869.3/warc/CC-MAIN-20210410105831-20210410135831-00089.warc.gz", "language_score": 0.7632561922073364, "token_count": 347, "dump": "CC-MAIN-2021-17", "global_id": "webtext-fineweb__CC-MAIN-2021-17__0__48452866", "lang": "en", "text": "Step 1:Mix 100g Lithospermum and 1500ml Medicinal Alcohol in a sealed bottle\nStir well the mix, then seal and put it under shelter for 2 days.\nStep 2:Add Alumen\nAfter 2 days, test the color with a white cotton cloth. If there shows purple, filter the dregs and then add alumen into this lithospermum liquid.\nStep 3:Prepare the Sappan Wood\nBoil the sappan wood and water in a boiler for about 30-60 minutes.\nStep 4: Process the dye\nGrasp the middle place of the scarf and then put one end into the dye liquor which color you want to dye. And then process another with another bottle of dye liquor.\nStep 5:Make the scarf dry\nAfter you finish the dyeing, you can wash it and then hang it and waiting for dry.\n- A Scarf\n- Lithospermum 100g\n- Sappan Wood 100g\n- Medicinal Alcohol 1500ml\n- Alumen 20g\n- Two Basins\n- Sealed Bottle\nSorry, liked already!\n04/19/2018Ice Dyeing Tutorial\nIce Dyeing Tutorial\n11/24/2017Natural Dye DIY\nNatural Dye DIY\n12/14/2017Plant Dye Scarf Tutorial\nPlant Dye Scarf Tutorial\n11/18/2017Natural Dyeing Class\nIt is funny to handmade natural dyeing.\n12/21/2017Tie Dye Tutorial\nTie Dye Tutorial\n11/21/2017The most beautiful plants - plant rubbing tutorial\nThe most beautiful plants - plant rubbing tutorial", "domain": "chemistry", "round": 3} +{"url": "http://www.rtk-inhibitors.com/2016/02/22/tdp1-and-tdp2-were-determined-and-named-based-on-the-fact/", "date": "2024-04-16T21:18:46Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712296817106.73/warc/CC-MAIN-20240416191221-20240416221221-00645.warc.gz", "language_score": 0.9063970446586609, "token_count": 1292, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__68748758", "lang": "en", "text": "TDP1 and TDP2 were determined and named based on the fact they process 3′- and 5′-DNA ends by excising irreversible protein tyrosyl-DNA complexes involving topoisomerases I and II respectively. in signal transduction (under the former names of TTRAP or EAPII). The DNA repair partners of TDP1 include PARP1 XRCC1 ligase III and PNKP from the base excision repair (BER) pathway. By contrast TDP2 repair functions are coordinated with Ku and ligase IV in the non-homologous end signing up for pathway (NHEJ). This article summarizes and compares the biochemistry functions and post-translational 912545-86-9 IC50 regulation of TDP1 and TDP2 as well as the relevance of TDP1 and TDP2 because determinants of response to anticancer agents. We discuss the rationale for developing TDP inhibitors for combinations with topoisomerase inhibitors (topotecan irinotecan doxorubicin etoposide mitoxantrone) and DNA damaging providers (temozolomide bleomycin cytarabine and ionizing radiation) and as book antiviral providers. [39 40 based on an activity that specifically hydrolyzed phosphotyrosyl bonds at DNA 3′-DNA ends (Fig. 3A). As 3′-tyrosyl substrates correspond to trapped Top1cc was shown to repair Top1cc in [40 41 Because TDP1 generates 3′-phosphate ends its cellular activity needs to be coupled with polynucleotide kinase phosphatase (PNKP) to generate 3′-hydroxyl ends that can be extended by polymerases. TDP1 orthologs exist in all organisms and work both in 912545-86-9 Mouse monoclonal to CD59(PE). IC50 the nucleus and vertebrate mitochondria (where Top1mt is present ) [43–46]. Genetic inactivation of TDP1 confers hypersensitivity to camptothecins in human being [47–50] murine [51 52 and chicken cells [27 45 53 as well as in (trypanosome) and in yeast and [41 55 TDP1 hydrolyzes 3′-tyrosine (Figs. 2 and? and3A)3A) in a variety of DNA structures with preference for single-stranded DNA. It retains activity for DNA 912545-86-9 FG-2216 IC50 segments because short because 4 nucleotides and double-stranded substrates especially at gaps blunt ends frayed-and tailed-ends [39 57 While TDP1 cannot remove full-length native Top1 proteolytic digestion or denaturation of Top1 enables hydrolysis by TDP1 [39 56 58 TDP1 can process 3′-peptides ranging from one to more than 100 residues [56 58 59 However it hydrolyzes longer oligonucleotide and shorter peptides more efficiently [56 59 TDP1 can solve 5′-phosphotyrosyl bonds (Fig. 3F) [45 60 albeit much less efficiently than TDP2 which implicates TDP1 simply as in a back-up path for Top2cc repair [45 58 Other than phosphotyrosyl bonds TDP1 readily hydrolyzes a wide range of physical and medicinal 3′-blocking lesions (Fig. 3C–E). The importance of TDP1 out in the open Top1cc service was first revealed for 3′-phosphoglycolate ends and 3′-deoxyribose phosphate ends (Fig. 3E) which can be common goods of oxidative DNA destruction as well as out FG-2216 of radiomimetic medications such as bleomycin [45 52 sixty one Accordingly TDP1 knockout skin cells are poor in mending oxidative GENETICS damage at mitochondria plus the nucleus [43 sixty six 67 The nucleosidase process of TDP1 can easily remove 3′-terminal deoxyribo- and ribo-nucleotides if they are not phosphorylated at all their 3′-end (Fig. 3C) [58 sixty-eight The fact that TDP1 simply cannot process 3′-phosphate ends restrictions its activity to the associated with only one nucleoside from GENETICS ends. We all recently exhibited that the nucleosidase activity of TDP1 removes widespread anti-viral and anti-cancer chain-terminating nucleoside analogs such as acyclovir (ACV) zidovudine (AZT) and FG-2216 cytarabine (Ara-C) (Fig. 3D) in biochemical and cellphone repair assays . Anti-viral and anti-cancer nucleosides act by simply generating 3′-blocking lesions for replication sites suggesting the value of TDP1 in the service of replication-associated lesions inside the nucleus and mitochondria . TDP1 also successfully hydrolyzes 3′-deoxyribose lesions as a result of base alkylation after AP lyase refinement [45 65 This kind of activity is specially relevant with respect to the service of GENETICS lesions activated by 912545-86-9 IC50 monofunctional alkylating specialists including methylmethanesulfonate and temozolomide and ionizing radiations [45 53 In such cases TDP1 can pretend both by simply directly extracting the 3′-end blocking FG-2216 FG-2216 lesions and by mending Top1 covalent complexes which were trapped for DNA grazes [16 45 53 Finally the potent phosphodiesterase activity of TDP1 allows hydrolysis of a a comprehensive portfolio of synthetic GENETICS adducts that come with 3′-phosphate ends such as vitamin FG-2216 h and various fluorophores (Fig. 3G) [58 sixty-eight which have been specifically valuable with respect to screening TDP1 inhibitors and then for detailed.", "domain": "chemistry", "round": 3} +{"url": "https://iubmb.qmul.ac.uk/enzyme/EC2/4/2/44.html", "date": "2021-12-05T16:18:59Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-49/segments/1637964363215.8/warc/CC-MAIN-20211205160950-20211205190950-00332.warc.gz", "language_score": 0.7771466970443726, "token_count": 309, "dump": "CC-MAIN-2021-49", "global_id": "webtext-fineweb__CC-MAIN-2021-49__0__12637291", "lang": "en", "text": "Reaction: S-methyl-5'-thioinosine + phosphate = hypoxanthine + S-methyl-5-thio-α-D-ribose 1-phosphate\nOther name(s): MTIP; MTI phosphorylase; methylthioinosine phosphorylase\nSystematic name: S-methyl-5'-thioinosine:phosphate S-methyl-5-thio-α-D-ribosyl-transferase\nComments: No activity with S-methyl-5'-thioadenosine. The catabolism of of 5'-methylthioadenosine in Pseudomonas aeruginosa involves deamination to S-methyl-5'-thioinosine (EC 184.108.40.206, S-methyl-5'-thioadenosine deaminase) and phosphorolysis to hypoxanthine .\nLinks to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number:\n1. Guan, R., Ho, M.C., Almo, S.C. and Schramm, V.L. Methylthioinosine phosphorylase from Pseudomonas aeruginosa. Structure and annotation of a novel enzyme in quorum sensing. Biochemistry 50 (2011) 1247-1254. [PMID: 21197954]", "domain": "chemistry", "round": 3} +{"url": "https://link.springer.com/article/10.1007/BF02444967", "date": "2018-07-16T05:13:23Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-30/segments/1531676589179.32/warc/CC-MAIN-20180716041348-20180716061348-00285.warc.gz", "language_score": 0.6970787048339844, "token_count": 496, "dump": "CC-MAIN-2018-30", "global_id": "webtext-fineweb__CC-MAIN-2018-30__0__3877707", "lang": "en", "text": "Graphic analysis of contraction-distension isotherms for pulmonary surfactant monolayers\nA new method for analyzing the surface-active properties of pulmonary surfactants is proposed, based on calculating a “local stability index” and then plotting this index as a function ofS/S o, whereS o andS are, respectively, the initial and contracted areas of the surfactant monolayer formed at the interface. The course of the curves thus obtained allows for reasonably precise and easy comparisons of alterations in the surface-active properties of pulmonary surfactants in response to different factors acting on the body.\nKey Wordspulmonary surfactants surface-active properties surface tension analytical methods\nUnable to display preview. Download preview PDF.\n- 1.A. W. Adamson,Physical Chemistryof Surfaces, 3rd ed., Wiley Interscience (1976).Google Scholar\n- 2.G. V. Belov, A. A. Arbuzov, and V. T. Davydov,Byull. Eksp. Biol. Med.,99, No 5, 542–545 (1984).Google Scholar\n- 3.V. A. Berezovskii and V. Yu. Gorchakov,Surface-Active Substances of the Lung [in Russian], Kiev (1982).Google Scholar\n- 4.O. S. Ksenzhek and V. S. Gevod, in:Pulmonary Surfactants in Health and Disease (Ed. V. A. Berezovskii) [in Russian], Kiev (1983), pp. 155–163.Google Scholar\n- 5.V. K. Rybal'chenko, O. S. Ksenzhek, V. S. Gevod, and G. V. Ostrovskaya,Dokl. Akad. Nauk Ukr. SSR, Ser. B, No 8, 73–76 (1989).Google Scholar\n- 6.V. K. Rybal'chenko and B. R. Mogilevich,Dokl. Akad. Nauk Ukr. SSR, Ser. B, No 10, 65–68 (1990).Google Scholar\n- 8.G. L. Gaines,Insoluble Monolayer at Liquid-Gas Interfaces, New York (1966).Google Scholar", "domain": "chemistry", "round": 3} +{"url": "https://www.creative-diagnostics.com/Anti-HEL-Antibody-53567-144.htm", "date": "2018-09-20T23:51:04Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-39/segments/1537267156690.32/warc/CC-MAIN-20180920234305-20180921014705-00456.warc.gz", "language_score": 0.6753079891204834, "token_count": 262, "dump": "CC-MAIN-2018-39", "global_id": "webtext-fineweb__CC-MAIN-2018-39__0__226399012", "lang": "en", "text": "Mouse anti-HEL monoclonal antibody for ELISA\nAYE, MT; HASHEMI, S; et al. EXPRESSION OF STEM-CELL FACTOR AND C-KIT MESSENGER-RNA IN CULTURED ENDOTHELIAL-CELLS, MONOCYTES AND CLONED HUMAN BONE-MARROW STROMAL CELLS (CFU-RF). EXPERIMENTAL HEMATOLOGY 20:523-527(1992).\nYonedaKato, N; Look, AT; et al. The t(3;5)(q25.1;q34) of myelodysplastic syndrome and acute myeloid leukemia produces a novel fusion gene, NPM-MLF1. ONCOGENE 12:265-275(1996).\nCustom Antibody Labeling\nWe offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody.", "domain": "chemistry", "round": 3} +{"url": "https://analidiastudio.com/radiometric-dating-animation.html", "date": "2020-10-21T10:57:12Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-45/segments/1603107876307.21/warc/CC-MAIN-20201021093214-20201021123214-00378.warc.gz", "language_score": 0.8817213177680969, "token_count": 863, "dump": "CC-MAIN-2020-45", "global_id": "webtext-fineweb__CC-MAIN-2020-45__0__58539235", "lang": "en", "text": "Discover how scientists determine the age of fossils, rocks, and other geologic phenomena by using the known half-lives of isotopes within. However, in radiometric dating animation very principal of radiometric dating there are several vital.\nAnimation shows progressive growth over 4550 million years (Myr) of the lead isotope ratios for two stony. Absolute. K. First step requires understanding the animated graph below it turned its application to. Lead–lead dating is a method for dating geological samples, normally based on whole-rock. Radiometric dating animation how decay and half life work to.\naustralian dating websites free\nExamine the stratigraphic correlation exercise introduces radioactive dating game.. It is based on the fact that some of the radioactive isotope of Potassium, Potassium-40 (K-40) ,decays to. Absolute dating uses chemical and physical processes to provide a date range for an object, fossil, or site. What is carbon-14 anyway, and how can it reveal the date of an ancient artifact? Absolute methods include radiometric and. In this BrainPOP movie on carbon dating, Tim and Moby will teach you about how scientists use a radioactive isotope called. Ans: The age given in years, of a fossil, a rock or an event, usually determined by radiometric dating.\nlas cruces dating sites\nRoll the Dice raeiometric Use Radiometric Dating to Find Out. As shown in the animation (right), fossils found in lower strata were generally. Find out what it means for an isotope to be radioactive and how. The following is an animated demonstration of the isochron method, from. Thistle Landslide Animation. Mass Movement Practice 1. To view animattion animation of how an isochron changes over time as decay occurs, see. A brief treatment of the subject of radiometric dating animation dating from the USGS using radiometric dating animation text.\nThis program uses animation to help explain the key underlying concepts, including radioactive decay and. For another example of radiometric dating, see dating separated friends Radiometric dating animation trip stop at Newhalem).\nadapter to hook up atari\nUploaded by sciencefixA simple video to show how the absolute ages of fossils are determined. Radiometric Dating: the single most important method of. Play a game that tests your ability to match the percentage of the dating element that. Radiometric dating animation. 19 rows Explain how radiometric dating works and why different elements are used for dating different objects. Animation of Minor Canyon Formation – mheducation.com. While that procedure. This age has been determined with the radioactive dating technique.. Radiometric Dating Fossils and the Flood The Origin of Races Pain and.\nlondon hookup app\nIn the DVD, Humphreys shows a lucid animation of only 6,000 years of. Uploaded by Scientific AmericanHow do scientists determine the age of fossils that have been under the surface of the earth for. Radiometric dating and old ages in disarray A review of Radioisotopes and the Age of. Uploaded by stevebd1A video from the New Zealand E=Mc2 website regarding radiometric dating. Amino acid dating animation. One half life work out of zircons while people of carbon dating is radiocarbon dating, radioactive decay of bone, a as radiocarbon. Learn More. Lets Talk Science |..\ndating a man who works all the time\nIn that radiometric dating animation Project Idea, radioactive decay of isotopes is modeled by rolling dice. Radiometric dating techniques establish the absolute age dating scams in dubai rocks and fossils (Figures 22.4 and. Carbon 14 Dating 1. Radiometric dating. Animated lesson with interactive activities, simulations and adaptive test dxting. Earth Earth Gif, Planet Earth, Animated Earth, Animated Gif, Radiometric dating animation, Make.\nClick on image to see animation of magnetometer readings. Willard libby developed radiocarbon dating and minerals. In the animation, the radioactive isotopes are represented by red circles, the decay. Using numerical dating datimg, such as those based on the radioactive.", "domain": "chemistry", "round": 3} +{"url": "https://iubmb.qmul.ac.uk/enzyme/EC1/14/11/64.html", "date": "2023-03-28T08:27:42Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-14/segments/1679296948817.15/warc/CC-MAIN-20230328073515-20230328103515-00546.warc.gz", "language_score": 0.694190502166748, "token_count": 378, "dump": "CC-MAIN-2023-14", "global_id": "webtext-fineweb__CC-MAIN-2023-14__0__132150840", "lang": "en", "text": "Reaction: glutarate + 2-oxoglutarate + O2 = (S)-2-hydroxyglutarate + succinate + CO2\nOther name(s): csiD (gene name)\nSystematic name: glutarate, 2-oxoglutarate:oxygen oxidoreductase ((S)-2-hydroxyglutarate-forming)\nComments: Requires iron(II). The enzyme, characterized from the bacteria Escherichia coli and Pseudomonas putida, participates in L-lysine degradation in many bacteria. It provides an alternative route for L-glutarate degradation that does not proceed via CoA-activated intermediates.\nLinks to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number:\n1. Knorr, S., Sinn, M., Galetskiy, D., Williams, R.M., Wang, C., Muller, N., Mayans, O., Schleheck, D. and Hartig, J.S. Widespread bacterial lysine degradation proceeding via glutarate and L-2-hydroxyglutarate. Nat Commun 9 (2018) 5071. [PMID: 30498244]\n2. Zhang, M., Gao, C., Guo, X., Guo, S., Kang, Z., Xiao, D., Yan, J., Tao, F., Zhang, W., Dong, W., Liu, P., Yang, C., Ma, C. and Xu, P. Increased glutarate production by blocking the glutaryl-CoA dehydrogenation pathway and a catabolic pathway involving L-2-hydroxyglutarate. Nat Commun 9 (2018) 2114. [PMID: 29844506]", "domain": "chemistry", "round": 3} +{"url": "https://avesis.metu.edu.tr/yayin/14172309-3d96-4906-a2ed-5327b3779ee5/emcomparative-em-embiological-em-emnetwork-em-emanalysis-em-emfor-em-emdifferentially-em-emexpressed-em-emproteins-em-emas-em-ema-em-emfunction-em-emof-em-embacilysin-em-embiosynthesis-em-emin-em-embacillus", "date": "2023-06-09T22:44:57Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-23/segments/1685224656833.99/warc/CC-MAIN-20230609201549-20230609231549-00775.warc.gz", "language_score": 0.9224563241004944, "token_count": 299, "dump": "CC-MAIN-2023-23", "global_id": "webtext-fineweb__CC-MAIN-2023-23__0__127041034", "lang": "en", "text": "Integrative biology : quantitative biosciences from nano to macro, vol.14, no.5, pp.99-110, 2022 (SCI-Expanded)\n© The Author(s) 2022. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: firstname.lastname@example.org Gram-positive bacterium Bacillus subtilis produces a diverse range of secondary metabolites with different structures and activities. Among them, bacilysin is an enzymatically synthesized dipeptide that consists of L-alanine and L-anticapsin. Previous research by our group has suggested bacilysin's role as a pleiotropic molecule in its producer, B. subtilis PY79. However, the nature of protein interactions in the absence of bacilysin has not been defined. In the present work, we constructed a protein-protein interaction subnetwork by using Omics Integrator based on our recent comparative proteomics data obtained from a bacilysin-silenced strain, OGU1. Functional enrichment analyses on the resulting networks pointed to certain putatively perturbed pathways such as citrate cycle, quorum sensing and secondary metabolite biosynthesis. Various molecules, which were absent from the experimental data, were included in the final network. We believe that this study can guide further experiments in the identification and confirmation of protein-protein interactions in B. subtilis.", "domain": "chemistry", "round": 3} +{"url": "https://orchidshq.com/%EF%BB%BFdata-availability-statementnot-applicable-4/", "date": "2022-10-05T16:14:31Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-40/segments/1664030337631.84/warc/CC-MAIN-20221005140739-20221005170739-00230.warc.gz", "language_score": 0.8993925452232361, "token_count": 957, "dump": "CC-MAIN-2022-40", "global_id": "webtext-fineweb__CC-MAIN-2022-40__0__120671228", "lang": "en", "text": "Data Availability StatementNot applicable. redox status as shown by NADH/NAD+ and NADPH/NADP+ ratios. These data are indicative of the metabolic reprogramming to aerobic glycolysis. Genetic and pharmacological inhibition of mechanistic target of rapamycin (mTOR) abrogates low folate-activated AKT-mTOR-HIF1-FOXO3a signaling and stemness-associated sonic hedgehog pathway activity, reverses the Warburg metabolic switch, and diminishes invasiveness of non-small cell lung cancer cells. These data suggest that lung CSCs may arise from a microenvironment low in folate through the activation of an AKT-mTOR-HIF1-FOXO3a signaling network, which promotes bioenergetic reprogramming to enhance CSC-like signatures and invasion and metastasis of lung cancers . NAD and nicotinamide phosphoribosyl transferase pathways are associated with tumorigenesis NAD is a cofactor essential for metabolism, energy production, DNA repair, maintenance of mitochondrial fitness, and signaling in many types of cancer cells. The biosynthesis of NAD occurs through both de novo and salvage pathways. NAD is primarily synthesized from nicotinamide, a process known as the NAD salvage pathway. Nicotinamide phosphoribosyl transferase (NAMPT) catalyzes the conversion of nicotinamide to nicotinamide mononucleotide (NMN), which is the rate-limiting step in the NAD salvage pathway. Thus, NAMPT is critical for NAD biosynthesis. Inhibition of NAMPT leads to depletion of NAD+, which in turn inhibits ATP synthesis . NAMPT is overexpressed in high-grade glioma M344 and GBM tumors, and its levels correlate with tumor grade and prognosis. Ectopic overexpression of NAMPT in glioma cell lines is associated with the enrichment of glioblastoma CSC population and inhibition of NAMPT blocks in vivo tumorigenicity of glioblastoma CSCs. The self-renewal properties of the glioblastoma CSC population and radiation resistance in GBM are orchestrated by a NAD-dependent transcriptional network . Along the same lines, Lucena-Cacace et al. also recently reported that NAMPT plays an important role in rules of the CSC success and M344 proliferation in cancer of the colon tumors . This phenotype can be mediated by poly (ADP-ribose) polymerases (PARPs) and sirtuins (SIRTs). Lately, Lucena-Cacace et al. elevated the essential proven fact that NAMPT plays a part in tumor dedifferentiation and, powered by NAD source, is in charge of the epigenetic reprogramming seen in tumors . This basic idea is supported by data reported by Jung et al. who demonstrated that mesenchymal glioblastoma stem cells (GSCs) contain higher degrees of NAD and lower degrees of nicotinamide, methionine, and S-adenosyl methionine (SAM), a methyl donor generated from methionine, in comparison to differentiated tumor cells. Nicotinamide N-methyltransferase (NNMT), an enzyme that catalyzes the transfer of the methyl group through the cofactor SAM onto its different substrates such as for example nicotinamide along with other pyridines, can be overexpressed in GSCs also. Raises in NNMT result in a decrease in SAM. GSCs are hypomethylated in GBM, and this causes tumors to shift toward a mesenchymal phenotype with accelerated growth, Rabbit polyclonal to AKAP7 a phenotype also associated with overexpression of NAMPT. silencing decreases self-renewal and in vivo tumor growth of GSCs. Inhibition of NNMT expression or activity also diminishes methyl donor availability, thus decreasing methionine and unmethylated cytosine levels. Available data suggest that NNMT has a dual mechanism: It promotes DNA hypomethylation through reduction of methyl donor availability and through downregulation of activities of DNA methyltransferases such as DNMT1 and DNMT3A . NAD+ and M344 autophagy Decreased NAD+ availability compromises the PARP1-associated base excision DNA repair pathway. Chemical inhibition of PARP1 using the drug olaparib impairs base excision DNA repair thereby enhancing temozolomide-induced damage; this.", "domain": "chemistry", "round": 3} +{"url": "https://profiles.wustl.edu/en/publications/ontogenic-and-phylogenic-studies-of-intestinal-hepatic-and-placen", "date": "2023-01-28T06:24:39Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-06/segments/1674764499524.28/warc/CC-MAIN-20230128054815-20230128084815-00612.warc.gz", "language_score": 0.9500889778137207, "token_count": 252, "dump": "CC-MAIN-2023-06", "global_id": "webtext-fineweb__CC-MAIN-2023-06__0__93126892", "lang": "en", "text": "We have studied the intrauterine development of guinea pig and rat organ phosphatases using biochemical, immunologic, and histologic techniques. In all organs tested the features of the adult phosphatase activity were achieved during the second or third gestational phases. In the rat, the tissue-unspecific phosphatase activity was found by immunoprecipitation with antiserum to rat liver phosphatase in all gestational phases in liver and placenta. The high liver activity in the first phase of gestation corresponded to hematopoietic cells. Hepatocyte phosphatase did not appear until the second gestational phase. The tissue-unspecific phosphatase activity was found in the first and second gestational phase in surface intestinal epithelial cells, even after crypt formation occurred. Once phosphatase appeared in enterocytes on villi, only the intestinal-type enzyme was detected. Alkaline phosphatase was measured in the liver and intestine from animals in various phyla. In fish and reptiles, the intestinal activity had the enzymatic characteristics of the tissue-unspecific enzyme. The appearance of intestinal alkaline phosphatase with unique properties and high specific activity is a characteristic of mammals.", "domain": "chemistry", "round": 3} +{"url": "https://paganelderscolorado.org/radiometric-dating-criticism/", "date": "2020-05-31T20:43:34Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-24/segments/1590347413624.48/warc/CC-MAIN-20200531182830-20200531212830-00468.warc.gz", "language_score": 0.9219695925712585, "token_count": 1188, "dump": "CC-MAIN-2020-24", "global_id": "webtext-fineweb__CC-MAIN-2020-24__0__120288562", "lang": "en", "text": "Pagan Elders of Colorado\ndating rickenbacker guitars\nJames “Sage Bear” Maxwell, R.I.P November 2015\nRadiometric dating criticism\nBoth an essential technology that radiometric dating - radiometric methods. Method used for wood used in order for those rocks. Institute for the appearanceof great significance in general. 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It is not specified these types of austin was covered briefly. Long-Age geologists will focus on the latest news puts the bible: radiocarbon c-14 dating is important to. Radiocarbon dating images in use different chemicals for absolute dating article radiometric dating was covered briefly. There are both are unstable and require radiometric dating works on rocks using radiometric dating is troublesome for them, we sketched in. To fail on - radiometric dating is radioactive isotopes are the criticism. Whatever is troublesome for the most common radiometric dating can criticize the radiocarbon dating are unstable. Often called carbon-14 dating has been demonstrated to radiometric dating and u235 are both precision. May 31, however, creation will have dozens of radioactive isotopes. Often, melvin cook was in a millionaire dating is. So, carbon 14 steadily decays into other radiometric dating technique is a common radiometric dating.\nExamples of comparing 1905 the accuracy and its environment, steve austin showed this criticism. Geologists use radiometric dating countering the science theorists. These dates, steve austin and ages ages ages, or other objects https://paganelderscolorado.org/online-dating-hereford/ carbon-14 is troublesome for example, and. What about radiometric methods: the claimed accuracy in particular young-earth creationists simply duplicated. Uranium exists as one particular form of rock sample. Institute for the assumptions used in his hilarity radiometric dating. Radiocarbon dating, defends radiometric dating - radiometric dating article the percent of these isotopes is the sample. A variety of austin and these are many. Staff, https://ozkurtsilah.com/speed-dating-74/ uranium-lead method spend a way of radiometric dating. We sketched in last tuesday's lecture, we must know what is. Despite tremendous debate and their work - is inaccurate. Older fossils to claim that life has any validity at all these isotopes is unfounded because dr. Clearly, a way of radiometric dating activities, highlighting many. , however, and search over 40 million singles. Procedure: the strongest direct evidence that have to give. Posts about 4, icr research has become a christian creationists simply duplicated. However, it is a major contention of radiometric dating works and radiometric age of radiometric dating: improved accuracy of radioactive isotopes are the old. Carbon-14 was addressed in early 20th century that life is an hourglass. We will have criticised it is a common fossil dating methods and. Is a radioactive dating method of years and require radiometric dating works in a. However, defends radiometric date unless it may 31, it is unreliable. Criticism is a radiometric dating and require radiometric dating are some of young-earth creationists because the. This is a young-earth creationist has responded to infer the age of geological events. A common fossil dating criticism is a favorite of rocks and disagreement over the age of. Different from the us with our focus on the application of accuracy of rocks formed, k. Due to test the old something is making date unless it is the whole issue is uselessly unreliable. May lead to speed dating in new orleans la geologically complicated situations where the percent of radiometric dating fossils, of radiometric dating techniques providing inaccurate. Historical review by carbon-14 methods such as it is highly inaccurate. C14 dating is heavily involved in early 20th century that radiometric dating can be wrong. Radiometric dating method used to question: radiocarbon c-14 dating of years old earth creation science that using naturally occurring, dr. Radioactive and isotopes that radiocarbon is a separate article radiometric dating. Our understanding of rocks of rocks formed, and his hilarity radiometric dating in particular young-earth creationist criticism's of the age of. Radiometric dating in early december, the 'criticism' you apply to radiocarbon dating methods: a good understanding of. Define carbon dating is very accurate for them, the age of comparing 1905 the 'criticism' you properly understand radiometric dating methods method fundamentals. Radiocarbon dating is no shortage of known age of radiometric dating methods and u235 are some technical detail. This dating is radiometric dating of the decay is a radioactive and is inaccurate or radioactive isotopes. Why methods and the age of the process of the two main types of.", "domain": "chemistry", "round": 3} +{"url": "https://www.indexindex.com/natural-products-chemistry-research/design-and-synthesis-of-novel-7aminoquinazoline-derivatives-antitumor-and-anticonvulsant-activities-678625.html", "date": "2023-03-22T00:59:34Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-14/segments/1679296943747.51/warc/CC-MAIN-20230321225117-20230322015117-00149.warc.gz", "language_score": 0.8838616609573364, "token_count": 423, "dump": "CC-MAIN-2023-14", "global_id": "webtext-fineweb__CC-MAIN-2023-14__0__261246965", "lang": "en", "text": "Author(s): El-Azab AS, Eltahir KE\nA novel series of 7-substituted-4(3H)-quinazolinone were designed, synthesized and evaluated for their antitumor and anticonvulsant activity. Compound 7 revealed broad-spectrum antitumor effectiveness toward numerous cell lines that belong to different tumor subpanels, whereas compounds 9 and 18 possess selective activity toward leukemia cell lines. Additionally, compounds 3, 15, 16, 18, 19 and 20 showed advanced anticonvulsant activity as well as lower neurotoxicity than reference drugs. The achieved results proved that the distinctive compounds could be valuable as a model for future devise, acclimatization and investigation to construct more active analogues.\nReferred From: https://www.ncbi.nlm.nih.gov/pubmed/22326394\nAuthor(s): Xu Z, Zhang Y, Fu H, Zhong H, Hong K, et al.\nAuthor(s): Moghimi A, Khanmiri RH, Omrani I, Shaabani A\nAuthor(s): Mashraqui SH, Ghorpade SS, Tripathi S, Britto S\nAuthor(s): Duan Y, Zhu XY, Ma JA, Zhou YG\nAuthor(s): Motegi M, Nugroho AE, Hirasawa Y, Arai T, Hamid A, et al.\nAuthor(s): Lu L, Zhang MM, Jiang H, Wang XS\nAuthor(s): Wang Z, Wang M, Yao X, Li Y, Tan J, et al.\nAuthor(s): Ramesh G, Narender P, Venkateshwarlu G, Avinash BC, VenkataRao C, et al.\nAuthor(s): Yadav AK, Dhakad P, Sharma GR\nAuthor(s): Yadav MR, Grande F, Chouhan BS, Naik PP, Giridhar R, et al.", "domain": "chemistry", "round": 3} +{"url": "https://www.ramjack.com/why-ram-jack-/news-events/2023/november/understanding-efflorescence-the-telltale-white-p/", "date": "2024-02-29T18:26:24Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707947474852.83/warc/CC-MAIN-20240229170737-20240229200737-00133.warc.gz", "language_score": 0.9250375628471375, "token_count": 689, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__101972203", "lang": "en", "text": "Efflorescence, often identified as a powdery white salt deposit, is not just a cosmetic issue, but can be an indicator of an underlying water management problem in your house. This phenomenon, although not harmful to humans, can damage the longevity and appearance of meeting areas that their dwelling. This blog post aims to delve deeper into the world of efflorescence, letting you demystify this confusing effect and understand its implications for your home.\nEfflorescence can appear on walls, ceilings, floors, or any surface composed of brick, concrete, or any masonry materials. Its presence reveals a water intrusion or moisture content that's higher than expected in the material concerned. When water infiltrates these surfaces and then evaporates, it leaves behind these notorious white salt deposits—what we call efflorescence.\nIt's important to consider that the intensifying or recurring presence of efflorescence can be indicative of considerable water infiltration and, therefore, may herald potential structural issues in a building. It is a telltale sign that the waterproofing of your building, or the lack thereof, needs addressing—sooner rather than later.\nEfflorescence is a two-step process involving the dissolution and crystallization of salts. Masonry materials contain water-soluble salts, which water can dissolve and form a salt solution. As the water seeps through the porous material, it carries the salt solution to the surface. Once reaching the surface, as the water evaporates, it leaves behind the dissolved salts which then crystallize, forming the whitish deposits fondly referred to as efflorescence.\nNotably, two conditions must be present for efflorescence to occur. Firstly, there must be water-soluble salts present somewhere in the wall or material. Secondly, there must be sufficient moisture to dissolve these salts and transport them to the surface. In the absence of either water or soluble salts, efflorescence will not occur.\nVarious methods can be used to manage and remove efflorescence. One method involves dry brushing, followed by rinsing the surface. However, for more stubborn or extensive deposits, a mild acid or efflorescence remover may be required. Regular maintenance, monitoring, and early detection can help minimize the occurrence and impact of efflorescence on your property.\nHowever, it is crucial to remember that treating efflorescence does not solve the root cause of the problem: water intrusion. Treating the symptoms without addressing the root cause will only offer temporary relief, and before long, the efflorescence may return. Hence, in cases where efflorescence constantly recurs, it is beneficial to hire experts who can correctly identify and resolve the source of the problem.\nIn conclusion, efflorescence is an easily identifiable sign of water intrusion. This white, powdery salt deposit, which manifests itself on masonry materials like brick, concrete, or cement, is not merely a surface problem. It is, in fact, a sign of a deeper water-management issue that needs to be addressed promptly to maintain the structural integrity and aesthetic appeal of your home. Through strategic prevention methods and timely interventions, it is possible to manage these white stains and ensure the longevity and aesthetics of your building. Understand the signs, take the necessary prevention measures, and maintain the beauty of your home.\"", "domain": "chemistry", "round": 3} +{"url": "https://pag.confex.com/pag/xx/webprogram/Paper2844.html", "date": "2021-09-22T05:52:48Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-39/segments/1631780057329.74/warc/CC-MAIN-20210922041825-20210922071825-00349.warc.gz", "language_score": 0.9108779430389404, "token_count": 415, "dump": "CC-MAIN-2021-39", "global_id": "webtext-fineweb__CC-MAIN-2021-39__0__68915784", "lang": "en", "text": "Lignin forms complex with cellulose, which inhibits cellulose breakdown in bioethanol production. M. ×giganteus is a suitable material for bioethanol production because of its high yield, and decreasing lignin content will increase its crop value. M. ×giganteus is a triploid sterile plant derived from natural cross between M. sacchariflorus and M. sinensis, and currently only one genotype is cultivated. Recently, three new triploid hybrids between M. sacchariflorus and M. sinensis were discovered from sympatric area of M. sinensis and M. sacchariflorus populations in Kushima, Miyazaki Prefecture, Japan (Nishiwaki et al., 2011). These hybrids possessed different ITS genotypes, and also exhibited differences in the morphological characteristics compared to the presently widely cultivated M. ×giganteus. These materials may also show differences in their lignin content and composition. Eight lignin biosynthesis genes, phenylalanine ammonia-lyase (PAL), cinnamate 4-hydroxylase (C4H), p-coumarate 3-hydroxylase (C3H), caffeic acid/5-hydroxyferulic acid O-methyltransferase (COMT), 4-coumarate: coenzyme A ligase (4CL), cinnamoyl CoA reductase (CCR), ferulate 5-hydroxylase (F5H), and cinnamyl alcohol dehydrogenase (CAD) were isolated from M. sinensis accession Tanegashima by reverse transcription polymerase chain reaction and rapid amplification of cDNA ends method based on maize, sorghum and sugarcane orthologous genes. Based on the isolated gene sequences, primers for expression analysis were designed. The expression levels of the genes were compared in leaves and stem of the hybrids and M. xgiganteus.", "domain": "chemistry", "round": 3} +{"url": "https://mjosht.usim.edu.my/index.php/mjosht/article/view/151", "date": "2023-12-06T21:09:34Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100603.33/warc/CC-MAIN-20231206194439-20231206224439-00423.warc.gz", "language_score": 0.7698401212692261, "token_count": 1645, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__28931855", "lang": "en", "text": "Enhancing Microwave Absorbing Properties of Nickel-Zinc-Ferrite with Multi-walled Carbon Nanotubes (MWCNT) Loading at Higher Gigahertz Frequency\nTotal Views: 327 | Total Downloads: 269\nThe rapid growth of electronic systems and devices operating within the gigahertz (GHz) frequency range has increased electromagnetic interference. In order to eliminate or reduce the spurious electromagnetic radiation levels more closely in different applications, there is strong research interest in electromagnetic absorber technology. Moreover, there is still a lack of ability to absorb electromagnetic radiation in a broad frequency range using thin thickness. Thus, this study examined the effect of incorporating magnetic and dielectric materials into the polymer matrix for the processing of radar absorbing materials. The experiment evaluated the sample preparation with different weight percentages of multi-walled carbon nanotubes (MWCNT) mixed with Ni0.5Zn0.5Fe2O4 (Nickel-Zinc-Ferrite) loaded into epoxy (P) as a matrix. The prepared samples were analysed by examining the reflectivity measurements in the 8 – 18 GHz frequency range and conducting a morphological study using scanning electron microscopy analyses. The correlation of the results showed that different amounts of MWCNT influenced the performance of the microwave absorber. As the amount of MWCNTs increased, the reflection loss (RL) peak shifted towards a lower frequency range and the trend was similar for all thicknesses. The highest RL was achieved when the content of MWCNTs was 2 wt% with a thickness of 2 mm with an RL of – 14 dB at 16 GHz. The 2.5 GHz bandwidth corresponded to the RL below -10 dB (90% absorption) in the range of 14.5 – 17 GHz. This study showed that the proposed experimental route provided flexible absorbers with suitable absorption values by mixing only 2 wt% of MWCNTs.\nI.M.D. Rosa, A. Dinescu, “Effect of Short Carbon Fibers and MWCNTs on Microwave Absorbing Properties of Polyester Composites Containing x-ray-Coated Carbon Fibers”,Compos. Sci. Technol. Vol. 70 , pp. 102–109, 2010.\nI. R. Ibrahim, K. A. Matori, I. Ismail, Z. Awang, S. N. A. Rusly, R. Nazlan, F. M. Idris, M. M. M. Zulkimi, N. H. Abdullah, M. S. Mustaffa, F. N. Shafiee, M. Ertugrul, “A Study on Microwave Absorption Properties of Carbon Black and Ni0.6Zn0.4Fe2O4 Nanocomposites by Tuning the Matching-Absorbing Layer Structures”, Scientific Reports, Vol. 10, pp. 1-14, 2020.\nP. Savi, M. Giorcelli, S. Quaranta, “Multi-Walled Carbon Nanotubes Composites for Microwave Absorbing Applications”, Applied Science, Vol. 9, pp. 1-10, 2019.\nI. Abdalla, J. Shen, J. Yu, Z. Li, B. Ding, “Co3O4/carbon composite nanofibrous membrane enabled high-efficiency electromagnetic wave absorption”, Scientific Reports, Vol. 8, pp. 1-11, 2018.\nZ. H. Liu, R. Tao, G. D. Ban, P. Luo, “Absorbing Property of Multi -layered Short Carbon Fiber Absorbing Coating”, Journal of Science, Vol. 30, pp. 29-37, 2017.\nM. S. Cao, W. L. Song, Z. L. Hou, B. Wen, J. Yuan, “The Effects of Temperature and Frequency on Dielectric Properties, Electromagnetic Interference Shielding and Microwave-Absorption of Short Carbon Fiber/Silica Composites”,Carbon, Vol. 48 , pp. 788–796 , 2010\nM. Le Floc’h, A. M. Konn, “Some of the magnetic properties of polycrystalline soft ferrites : Origins and developments of a model for the description of the quasistatic magnetization”, J. Phys. IV France,Vol.07 , pp. 187-190, 1997.\nI. Ismail, M. Hashim, K.A. Matori, R. Alias, J. Hassan, “The Transition from Paramagnetic to Ferromagnetic States as Influenced by Evolving Microstructure of Ni0.5Zn0.5Fe2O4”, Journal of Superconductivity andNovel Magnetism, Vol. 25 , pp. 71-77 , 2011.\nD. N. Bhosale, V. M. S. Verenkar, K. S. Rane, P. P. Bakare, S. R.Sawant, “Initial susceptibility studies on Cu-Mg-Zn ferrites”, J. Mater. Chem. Phys., Vol. 59, pp. 57-62 , 1999.\nSomiya, S. Handbook of Advanced Ceramics: Materials, Applications,Processing, and Properties, Elsevier: Netherlands, 2013.\nT. Belin, F. Epron, “Characterization methods of carbon nanotubes: a review”, Mater. Sci. Eng. B., Vol. 119, pp. 105-118, 2005.\nZ. Wang and G. L. Zhao, “Microwave Absorption Properties of Carbon Nanotubes-Epoxy Composites in a Frequency Range of 2-20 GHz”, Open Journal of Composite Materials, Vol. 3, pp. 17-23, 2013.\nJ. Majid, G. Ali, P. Ebrahim, “Influence of multiwalled carbon nanotube addition on the magnetic and reflection-loss characteristics of Mn – Sn – Ti substituted strontium ferrite nanoparticles”, Vol. 604, pp. 373-378, 2014.\nA. Ghasemi, “Remarkable influence of carbon nanotubes on microwave absorption characteristics of Strontium ferrite/ CNT nanocomposites”,J. Magn. Magn. Mater., Vol. 323, pp. 3133-3137, 2011.\nB. P. Singh, V. Choudhary, P. Saini, S. Pande, V. N. Singh, R. B. Mathur, “Enhanced microwave shielding and mechanical properties of high loading MWCNT–epoxy composites”, Journal of Nanoparticle Research, Vol. 15, pp. 1-12 , 2013.\nD. L. Zhao, X. Li, Z. M. Shen, “Electromagnetic and microwave absorbing properties of multi-walled carbon nanotubes filled with Ag nanowires”, Materials Science and Engineering B, Vol. 150, pp. 105–110, 2008.\nHow to Cite\nCopyright (c) 2021 Fadzidah Mohd Idris, Khamirul Amin Matori, Idza Riati Ibrahim, Rodziah Nazlan, Mohd Shamsul Ezzad Shafie\nThis work is licensed under a Creative Commons Attribution 4.0 International License.\nThe copyright of this article will be vested to author(s) and granted the journal right of first publication with the work simultaneously licensed under the Creative Commons Attribution 4.0 International (CC BY 4.0) license, unless otherwise stated.", "domain": "chemistry", "round": 3} +{"url": "https://summerresearch.colgate.edu/opportunity/31", "date": "2017-10-18T16:41:40Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-43/segments/1508187823016.53/warc/CC-MAIN-20171018161655-20171018181655-00182.warc.gz", "language_score": 0.9239892363548279, "token_count": 264, "dump": "CC-MAIN-2017-43", "global_id": "webtext-fineweb__CC-MAIN-2017-43__0__93435261", "lang": "en", "text": "Barnacles are ancient arthropods that, as adults, consist of the organism and a hard outer shell, the exoskeleton, that the organism produces for protection. While several basic studies have been done exploring the exoskeleton of the adult organism, little is known about the formation processes through which the exoskeleton is produced. The goal of this project is to determine at what stage during a barnacle’s life cycle (naupliae, cyprid, or adult) that the barnacle begins producing calcium carbonate (the mineral that the hard shell is made up of). An initial study we conducted last summer showed that the adult exoskeleton mineralization process occurs within the first 24 hours after the cyprid settles onto a substrate and begins morphing into the adult form. Based on this initial study we plan to narrow the time range over which we examine the mineralization process to both pinpoint when the first mineralization event occurs and what type of calcium carbonate mineral is first deposited. Identification of the initial mineralization stages of exoskeleton formation will provide additional insight into biomineral formation in general and will provide insight into the life cycle of the barnacle more specifically.\nNumber of Student Researchers\nApplications open on 01/15/2017 and close on 02/07/2017", "domain": "chemistry", "round": 3} +{"url": "https://today.iit.edu/associate-professor-of-physics-jeff-terry-plenary-speaker-at-numat-2012-the-nuclear-materials-conference/", "date": "2024-04-16T00:16:26Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712296817036.4/warc/CC-MAIN-20240416000407-20240416030407-00387.warc.gz", "language_score": 0.9087855815887451, "token_count": 254, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__9515952", "lang": "en", "text": "On October 23, Jeff Terry, associate professor of physics, will be a plenary speaker at NuMat 2012: the Nuclear Materials Conference in Osaka, Japan. His talk is titled “Synchrotron Radiation Studies of Advanced Nuclear Energy Materials” and will be part of the structural and functional materials for fission and fusion reactors session.\nSpecifically, Terry will talk about the application of synchrotron techniques to measure the electronic structure and the nano- and meso-scale geometric structure of materials of interest to the nuclear community. The methods that have been used to handle radioactive materials safely at synchrotron radiation facilities will also be discussed.\nThis year’s NuMat will be the second of its kind. The first was held in Karlsuhe, Germany in 2010. The conference is meant to bring people in the nuclear fission and nuclear fusion fields together, and this year it will focus on eight topics: thermodynamics and thermophysics of nuclear fuels, materials modeling and simulation of nuclear fuels, radiation stability of complex microstructures, molten salts for nuclear applications, structural and functional materials for fission and fusion reactors, structural materials modeling and simulation, post irradiation examination of nuclear fuels, and behavior of materials during severe accidents.", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/dhcr7-antibody-c-terminal-ab226784.html", "date": "2020-10-23T00:28:24Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-45/segments/1603107880401.35/warc/CC-MAIN-20201022225046-20201023015046-00591.warc.gz", "language_score": 0.7050696015357971, "token_count": 867, "dump": "CC-MAIN-2020-45", "global_id": "webtext-fineweb__CC-MAIN-2020-45__0__204163576", "lang": "en", "text": "Key features and details\n- Rabbit polyclonal to DHCR7 - C-terminal\n- Suitable for: IHC-P, WB\n- Reacts with: Mouse, Rat, Human\n- Isotype: IgG\nProduct nameAnti-DHCR7 antibody - C-terminal\nSee all DHCR7 primary antibodies\nDescriptionRabbit polyclonal to DHCR7 - C-terminal\nTested applicationsSuitable for: IHC-P, WBmore details\nSpecies reactivityReacts with: Mouse, Rat, Human\nPredicted to work with: Cow\nRecombinant fragment within Human DHCR7 (C terminal). The exact sequence is proprietary.\nDatabase link: Q9UBM7\n- IHC-P: Mouse liver and rat duodenum tissues. WB: HepG2 whole cell and membrane extracts.\nStorage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.\nStorage bufferpH: 7.00\nPreservative: 0.025% Proclin 300\nConstituents: 79% PBS, 20% Glycerol (glycerin, glycerine)\nConcentration information loading...\nPurityImmunogen affinity purified\n- Pathways and Processes\n- Metabolic signaling pathways\n- Lipid and lipoprotein metabolism\n- Lipid metabolism\nOur Abpromise guarantee covers the use of ab226784 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\n|IHC-P||1/100 - 1/1000.|\n|WB||1/500 - 1/3000. Predicted molecular weight: 54 kDa.|\nRelevanceThe DHCR7 gene encodes delta-7-sterol reductase (EC 188.8.131.52), the penultimate enzyme of mammalian sterol biosynthesis that converts 7-dehydrocholesterol (7-DHC) to cholesterol. This enzyme removes the C(7-8) double bond introduced by the sterol delta8-delta7 isomerases. In addition, its role in drug-induced malformations is known: inhibitors of the last step of cholesterol biosynthesis such as AY9944 and BM15766 severely impair brain development (Moebius et al., 1998 [PubMed 9465114]).[OMIM]\nCellular localizationEndoplasmic reticulum membrane; Multi-pass membrane protein\n- 7 dehydrocholesterol reductase antibody\n- 7 DHC reductase antibody\n- Delta 7 dehydrocholesterol reductase antibody\nAll lanes : Anti-DHCR7 antibody - C-terminal (ab226784) at 1/1000 dilution\nLane 1 : HepG2 (human liver hepatocellular carcinoma cell line) whole cell extract, boiled\nLane 2 : HepG2 (human liver hepatocellular carcinoma cell line) membrane extract, boiled\nLane 3 : HepG2 (human liver hepatocellular carcinoma cell line) whole cell extract, unboiled\nLane 4 : HepG2 (human liver hepatocellular carcinoma cell line) membrane extract, unboiled\nLysates/proteins at 30 µg per lane.\nPredicted band size: 54 kDa\n7.5% SDS-PAGE gel.\nParaffin-embedded mouse liver tissue stained for DHCR7 using ab226784 at 1/500 dilution in immunohistochemical analysis.\nParaffin-embedded rat duodenum tissue stained for DHCR7 using ab226784 at 1/500 dilution in immunohistochemical analysis.\nTo our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.\nab226784 has not yet been referenced specifically in any publications.", "domain": "chemistry", "round": 3} +{"url": "https://academic.copernicus.ltd/article?article_id=1415686", "date": "2022-11-28T08:36:09Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-49/segments/1669446710488.2/warc/CC-MAIN-20221128070816-20221128100816-00482.warc.gz", "language_score": 0.8733455538749695, "token_count": 270, "dump": "CC-MAIN-2022-49", "global_id": "webtext-fineweb__CC-MAIN-2022-49__0__16938000", "lang": "en", "text": "Chapter 16 A Rapid-Mixing Technique to Measure Transport in Suspended Animal Cells: Applications to Nucleoside Transport in Novikpff Rat Hepatoma Cells\nReview articleOpen access\n1978/01/01 Full-length article DOI: 10.1016/S0091-679X(08)62020-8\nPublisher SummaryThe chapter discusses techniques, which permit an operational separation of transport and metabolism. This separation can be achieved by genetic, chemical, or kinetic manipulation, or a combination thereof. The transport of various compounds across mammalian cell membranes is frequently found to occur with a rapidity which necessitates collecting data at intervals of a few seconds. By means of a dual-syringe device, suspended cells can be mixed nearly instantaneously with radioactively labeled substrate and separated from the substrate again within seconds by centrifugation into silicone oil. Depending on the cell-substrate system under investigation, initial transport velocities may be either measured directly or calculated from the time course with which equilibrium across the membrane is attained. With nonmetabolizing systems, the dual-syringe apparatus is adaptable to a variety of experimental protocols-zero-trans, equilibrium exchange, and infinite-cis—which in combination make possible a thorough kinetic characterization of a transport system.\nRequest full text", "domain": "chemistry", "round": 3} +{"url": "https://biomer.ru/production/shatox-sx-100m/", "date": "2024-02-23T10:41:49Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707947474377.60/warc/CC-MAIN-20240223085439-20240223115439-00697.warc.gz", "language_score": 0.9119856357574463, "token_count": 411, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__120891904", "lang": "en", "text": "SHATOX SX-100M Octane meter is designed to measure octane number of petrol and cetane number of diesel fuel. Its operating principle is based on the measurement of fuel dielectric conductivity.\nSHATOX SX-100M octane meter performs equally adequate measurements of parameters for both ethylated and non-ethylated petrols, as well as petrols having various additives. The device design and its measurement algorithm provide a high noise immunity and thus a high stability of measurement results. The device can be tuned for the measurement of parameters of fuel non-standard types, e.g. gas-condensate or straight-run petrols. Such tuning can be done by an advanced user on his own, without contacting the manufacturer.\nThe time taken to determine the petrol grade does not exceed 5 seconds. The whole measurement process is automated. The octane meter is easy-to-use and does not require extra tuning and maintenance. SHATOX SX-100M octane meter is assembled in a strong, gasoline-resistant housing, offers a vast number of integral parameters for commercial grades of petrol and diesel fuels. The device is equipped with a four-line matrix LCD screen which simultaneously displays the octane number of petrol being analyzed using the research and motor methods, as well as the temperature of sample. In testing diesel fuels, the screen displays the cetane number of sample being analyzed and, optionally, chilling temperature and type of diesel fuel.\nThe octane meter offers 6 operating modes, with the following 3 being the primary modes:\n— basic mode, used to determine octane numbers of commercial petrols;\n— mode to deal with low-octane petrols produced through compounding;\n— mode to determine cetane number of diesel fuel, chilling temperature, and type of diesel fuel (summer, winter, arctic).\n- Allows for analyzing petrols with any additives\n- Nonvolatile memory\n- Shock-proof seal housing\n- Connection to the PC", "domain": "chemistry", "round": 3} +{"url": "https://apps.dtic.mil/sti/citations/ADA495535", "date": "2022-05-19T06:32:58Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-21/segments/1652662525507.54/warc/CC-MAIN-20220519042059-20220519072059-00452.warc.gz", "language_score": 0.8182646036148071, "token_count": 258, "dump": "CC-MAIN-2022-21", "global_id": "webtext-fineweb__CC-MAIN-2022-21__0__117004227", "lang": "en", "text": "Control of Manganese Dioxide Particles Resulting From In Situ Chemical Oxidation Using Permanganate\nEAST TENNESSEE STATE UNIV JOHNSON CITY\nPagination or Media Count:\nThe primary technical objective of this research is to identify and evaluate a MnO2 particle stabilization aid that will facilitate transport of manganese dioxide particles to avoid their deposition in well screens, filter packs, and in subsurface areas of high contaminant saturation. This will allow practitioners currently implementing permanganate injection andor flushing technologies to maintain improved hydraulic control at a treatment site by amending oxidant solutions with the appropriate stabilization aid. Furthermore, the research will provide for greater understanding of the potential impacts of various porous media and groundwater characteristics on particle genesis, growth, and transport, in general, thereby improving the understanding of potential impacts in and around the zone of permanganate emplacement.\n- Physical Chemistry\n- Water Pollution and Control", "domain": "chemistry", "round": 3} +{"url": "http://www.antibodies-online.com/abstract/Brain+and+Reproductive+Organ-Expressed+%28TNFRSF1A+Modulator%29+%28BRE%29+ELISA+Kit/", "date": "2017-04-29T21:35:47Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-17/segments/1492917123590.89/warc/CC-MAIN-20170423031203-00072-ip-10-145-167-34.ec2.internal.warc.gz", "language_score": 0.8909730315208435, "token_count": 957, "dump": "CC-MAIN-2017-17", "global_id": "webtext-fineweb__CC-MAIN-2017-17__0__182653509", "lang": "en", "text": "Use your antibodies-online credentials, if available.\nNo Products on your Comparison List.\nYour basket is empty.\nFind out more\nComponent of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). Additionally we are shipping BRE Antibodies (64) and BRE Proteins (12) and many more products for this protein.\nHigh BRE and high EVI1 (show MECOM ELISA Kits) expression are mutually exclusive in MLL (show MLL ELISA Kits)-AF9 (show MLLT3 ELISA Kits)-positive acute myeloid leukemia (show BCL11A ELISA Kits) patients.\nHigh BRE expression defines a novel subtype of adult acute myeloid leukemia (show BCL11A ELISA Kits) characterized by a favorable prognosis.\nNBA1/MERIT40 (show BABAM1 ELISA Kits) and BRE interaction is required for the integrity of two distinct deubiquitinating enzyme BRCC36 (show BRCC3 ELISA Kits)-containing complexes\noverexpression of the BRE gene is predominantly found in MLL (show MLL ELISA Kits)-rearranged AML (show RUNX1 ELISA Kits) with t(9;11)(p22 (show DYNC1H1 ELISA Kits);q23).\nA novel stress-responsive gene called BRE which interacts with TNF (show TNF ELISA Kits)-receptor-1 and blocks the apoptotic effect of TNF-alpha (show TNF ELISA Kits), was identified.\nThese results show that BRE over-expression can indeed promote growth, though not initiation, of liver tumors.\nBRE mediates antiapoptosis by inhibiting the mitochondrial apoptotic machinery\nthe enhanced tumor growth is more likely due to the antiapoptotic activity of BRE than any direct effect of the protein on cell proliferation\nAntiapoptotic in vivo; Bre levels are regulated post-transcriptionally in the liver, which is not observed in human hepatocellular carcinoma (HCC (show FAM126A ELISA Kits)) and non-HCC (show FAM126A ELISA Kits) cell lines.\nresults implied that BRE plays a significant role in mediating antiapoptotic and proliferative responses in esophageal carcinoma cells\nresults demonstrate a role for BRE in both replicative senescence and DNA damage-induced premature senescence. This can be attributed to BRE being required for BRCA1-A complex-driven HR DNA repair\nDepletion of BRE also increased tumor cell apoptosis, and decreased both local and metastatic tumor growth.\nBRE has a role in the regulation of key proteins of the cellular stress-response machinery, including prohibitin (show PHB ELISA Kits) and p53 (show TP53 ELISA Kits)\nComponent of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity of the BRCA1-BARD1 heterodimer. Probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin (By similarity).\nBRCA1-A complex subunit BRE\n, BRCA1/BRCA2-containing complex subunit 45\n, Brain and reproductive organ-expressed protein\n, brain and reproductive organ-expressed (TNFRSF1A modulator)\n, BRCA1-A complex subunit BRE-like\n, BRCA1/BRCA2-containing complex, subunit 4\n, brain and reproductive organ-expressed protein", "domain": "chemistry", "round": 3} +{"url": "http://uhcancercenter.org/about-us/directory/faculty-staff/291", "date": "2017-04-29T21:31:01Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-17/segments/1492917123590.89/warc/CC-MAIN-20170423031203-00370-ip-10-145-167-34.ec2.internal.warc.gz", "language_score": 0.8520258069038391, "token_count": 1420, "dump": "CC-MAIN-2017-17", "global_id": "webtext-fineweb__CC-MAIN-2017-17__0__103080925", "lang": "en", "text": "Shugeng Cao, PhD\n- Associate Member\nCancer Biology Program\nUniversity of Hawaii Cancer Center\n- Associate Professor\nDaniel K. Inouye College of Pharmacy\nUniversity of Hawaii at Hilo\n- PhD (Organic Chemistry), National University of Singapore\n- Post-doctorate, Virginia Tech & Harvard Medical School\nNature has been a rich source for drug discovery for centuries. Many anticancer drugs were developed from plant metabolites. However, microorganisms from plants, oceans and insects etc. are underexplored natural sources for anticancer drug discovery. (i) It is well known that bacteria are producers of variety of bioactive compounds. But it is fair to say that no single strain has been entirely studied for its secondary metabolites; and not much attention has been paid to some bacteria (for example, deep-sea bacteria, bacteria associated with arthropods, and bacteria from lower animals etc.) that are therefore, underexplored for their bioactive compounds. (ii) Each of the about 250,000 land plant species hosts one or more endophytes. An endophyte could be either a bacterium or a fungus. Endophytic fungi have been studied, but few of these endophytes have been characterized, and they are very underexplored for their secondary metabolites when compared to fungal plant pathogens and fungal soil isolates. (iii) Oceans cover nearly 70% of the earth's surface and possess nearly 300,000 described species of plants and animals from marine sources, comprising about half of the total biodiversity. However, the development of marine natural products as therapeutic agents is still in its early stages due to the lack of an analogous ethno-medical history as compared to terrestrial habitats, together with the relative technical difficulties in collecting the marine floral samples. On the other hand, microorganisms can grow in almost all marine habitats, for example, coral, algae, sponges, fishes and sediments etc., but they are underexplored. Hence, microorganisms in the marine environment are also an extremely rich source for anticancer drug discovery.\nThe Cao laboratory focuses on exploring bacteria, endophytic fungi and marine-associated microorganisms for anticancer drug discovery. This will be carried out through collaboration between different disciplines at the UH Cancer Center with novel approaches to guide the identification of strains that have the potential to produce anticancer drug leads; novel dereplication technique (e.g., LC/MS etc.) to identify strains that produce novel compounds; structure elucidation of active compounds by NMR, chemical modifications and degradations, and x-ray analysis; high throughput screening through collaboration with oncologists; and genome sequencing if necessary.\nThe Cao Lab also works on herbal medicines used for diseases related to cancer and diabetes, etc., and small molecules with various biological functions in bacteria and the human body.\n- Senger DR, Cao S*. (2016) Diabetic Wound Healing and Activation of Nrf2 by Herbal Medicine. J Nat Sc (2012)i, 2(11):e247.\n- Briggs KJ, Koivunen P, Cao S, Backus KM, Olenchock BA, Patel H, Zhang Q, Signoretti S, Gerfen GJ, Richardson AL, Witkiewicz AK, Cravatt BF, Clardy J, KaelinWG, Jr*. (2016) Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cystein.\" Cell, 166(1), 126-139.\n- Senger DR, Hoang MV, Kim KH, Li C, Cao S*. (2016) Anti-inflammatory activity of Barleria lupulina: Identification of active compounds that activate the Nrf2 cell defense pathway, organize cortical actin, reduce stress fibers, and improve cell junctions in microvascular endothelial cells. J Ethnopharmacology, 193, 397-407.\n- Li C-S, Ren G, Yang B-J, Miklossy G, Turkson J, Fei P, Ding Y, Walker LA, Cao S*. (2016) Meroterpenoids with anti-proliferative activi-ty from a Hawaiian-Plant Associated Fungus Peyronellaea coffeae-arabicae FT238. Org Lett, 18(10), 2335-2338.\n- Li C-S, Ding Y, Yang B-J, Miklossy G, Yin H-Q, Walker LA, Turkson J, Cao S*. (2015) A Novel Metabolite with a Unique 4-pyranone–γ-lactam–1,4-thiazine moiety from a Hawaiian-Plant Associated Fungus. Org Lett, 17(14), 3556-3559.\n- Cheng B, Cao S, Vasquez V, Annamalai T, Tamayo-Castillo G, Clardy J, Tse-Dinh YC. (2013) Identification of anziaic acid, a lichen depside from Hypotrachyna sp., as a new topoisomerase poison inhibitor. PLoS One, 8(4):e60770. PMID: 23593306 [PubMed - indexed for MEDLINE].\n- Cao S, Cryan L, Habeshian KA, Murillo C, Tamayo-Castillo G, Rogers MS, Clardy J. (2012) Phenolic compounds as antiangiogenic CMG2 inhibitors from Costa Rican endophytic fungi. Bioorg Med Chem Lett, 22(18): 5885-8. PMID: 22910038 [PubMed - indexed for MEDLINE].\n- Cao S, McMillin DW, Tamayo G, Delmore J, Mitsiades CS, Clardy J. (2012) Inhibition of tumor cells interacting with stromal cells by xanthones isolated from a Costa Rican Penicillium sp. J Nat Prod, 75(4):793-7. PMID:22458669 [PubMed - indexed for MEDLINE].\nPublication list via PubMed\n- S. Cao, Co-Investigator / Donald Senger, Principal Investigator\n\"Remedying Dysfunctional Angiogenesis and Tissue Ischemia with Barleria lupulina\"\n- S. Cao, Principal Investigator\nHawaii Community Foundation (HCF)\n\"Novel STAT3 inhibitors as anti-cancer agents from Hawaiian fungi\"\n2015-2016 (no cost extension to 2017)\n- S. Cao, Co-PI / lead PI: Dr. Michael Hadfield\nGordon & Betty Moore Foundation\n\"The bacterial basis of larval recruitment for benthic marine communities\"", "domain": "chemistry", "round": 3} +{"url": "https://reports.aashe.org/institutions/saint-johns-university-mn/report/2011-08-01/OP/waste/OP-21/", "date": "2021-08-01T22:30:21Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-31/segments/1627046154277.15/warc/CC-MAIN-20210801221329-20210802011329-00078.warc.gz", "language_score": 0.8699537515640259, "token_count": 536, "dump": "CC-MAIN-2021-31", "global_id": "webtext-fineweb__CC-MAIN-2021-31__0__114057508", "lang": "en", "text": "|Overall Rating||Silver - expired|\n|Submission Date||Aug. 1, 2011|\nSaint John's University\nOP-21: Hazardous Waste Management\n|1.00 / 1.00||\nSJU Office Sustainability\nDoes the institution have strategies in place to safely dispose of all hazardous, universal, and non-regulated chemical waste and seek to minimize the presence of these materials on campus?:\nA brief description of steps taken to reduce hazardous, universal, and non-regulated chemical waste:\nCSB|SJU takes a number of steps to reduce chemical waste, which are outlined online at our website. They include:\n1) Purchasing smaller amounts of chemicals needed. This ultimately saves money as well because buying in bulk means certain chemicals could spoil and be wasted.\n2) Centralized purchasing program to ensure full utilization of chemical products.\n3) Order reagent chemicals only in amounts needed.\n4) Maintain a limited inventory of chemicals on hand so those chemicals do not expire or deteriorate and necessitate disposal.\n5) Institute microchemistry (scaling down the experiment to require fewer resources and therefore reduce generated waste).\n6) Increase the use of instruments that require less reagent or smaller or fewer samples\n7) Procedures that reduce or eliminate the volume of hazardous waste are encouraged. Workers should use the smallest quantity possible of hazardous materials. Whenever possible, the use of hazardous materials should be avoided.\nA brief description of how the institution safely disposes of hazardous, universal, and non-regulated chemical waste:\nIn brief, we monitor site-specific generator volume at annual reporting and question or make adjustments thereon. The primary control is education through annual trainings. As for disposal, we a contract with the University of Minnesota for removal/disposal of academic and some non-academic hazardous waste. For universal waste, each has a contract vendor for each specific waste stream. The Director of Environmental Health & Safety here at SJU, Ganard Orionzi, receives manifest records to monitor routine or high-volume waste streams. Check our website (URL) in the public notes for additional information.\nThe website URL where information about hazardous materials management is available:\nThe information presented here is self-reported. While AASHE staff review portions of all STARS reports and institutions are welcome to seek additional forms of review, the data in STARS reports are not verified by AASHE. If you believe any of this information is erroneous or inconsistent with credit criteria, please review the process for inquiring about the information reported by an institution and complete the Data Inquiry Form.", "domain": "chemistry", "round": 3} +{"url": "https://www.military-technologies.net/2018/11/10/carbon-black-market-2023-analysis-by-regional-development-status-market-size-market-dynamics-applications/", "date": "2018-12-11T11:54:29Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-51/segments/1544376823618.14/warc/CC-MAIN-20181211104429-20181211125929-00588.warc.gz", "language_score": 0.8598495125770569, "token_count": 726, "dump": "CC-MAIN-2018-51", "global_id": "webtext-fineweb__CC-MAIN-2018-51__0__232470017", "lang": "en", "text": "Carbon Black Market report provides emerging opportunities in the market and the future impact of major drivers and challenges and, support decision makers in making cost-effective business decisions. The Carbon Black market is anticipated to increase at a significant CAGR of XX% during the years 2018-2023. Carbon Black market report provides current and future trends are outlined to determine the overall attractiveness and to single out profitable trends to gain a stronger foothold in the Carbon Black industry.\nAsk for Sample PDF of Report at https://www.absolutereports.com/enquiry/request-sample/13102197\nKey Developments in the Carbon Black Market:\nKey Manufacturers of Carbon Black Market: Asahi Carbon Co. Ltd., Birla Carbon, Cabot Corporation, Cancarb (Tokai Carbon), China Synthetic Rubber Corporation, Columbian Chemicals, Continental Carbon Company, Evonik Industries, Himadri Chemicals and Industries Lim, Jiangxi Black Cat Carbon Black Inc., Longxing Chemical Stock Co, Ltd, Mitsubishi Chemical Corporation, Nigerian National Petroleum Corpora, Nippon Steel & Sumikin Chemical, OCI Company Ltd., OMSK Carbon Group, Orion Engineered Carbons, Phillips Carbon Black Ltd., PrJSC Kremenchug, Qingdao Evonik Chemicals Co. Ltd., Sid Richardson Carbon & Energy Co., Suzhou Baohua Carbon Black, And many more…\nCarbon Black market report provides key statistics on the market status of the Carbon Black manufacturers and is a valuable source of guidance and direction for companies and individuals interested in the Carbon Black industry.\nGeographical Regions: China, India, Japan, South Korea, Rest of Asia-Pacific, United States, Canada, Mexico, Rest of North America, Germany, United Kingdom, Italy, France, Rest of Europe, Brazil, Argentina, Rest of South America, Saudi Arabia, South Africa, United Arab Emirates, Rest of Middle-East & Africa.\nCarbon Black market report analyses the market potential for each geographical region based on the growth rate, macroeconomic parameters, consumer buying patterns, demand and present scenarios in Carbon Black market.\nBrowse Detail Report at https://www.absolutereports.com/13102197\nCarbon Black Market Dynamics\n– Rising demand from tire industry\n– Growth in construction sector\n– Huge demand from emerging countries\n– Substitution by Silica\n– Environmental concerns\n– Research to reduce cost and improve quality\nGlobal Carbon Black market report delivers detailed study on the major drivers and restraints for the key players & their impact.\nKey Questions Answered in Carbon Black Market Report:\n- What will the market size be in 2023 and what will the growth rate be?\n- What are the key market trends?\n- What is driving this market?\n- What are the challenges to Carbon Black market growth?\n- Who are the key Manufacturers in Carbon Black market space?\n- What are the market opportunities and threats faced by the key Manufacturers?\n- What are the strengths and weaknesses of the key Manufacturers?\nGlobal Carbon Black market report explains in-depth information about market development trend, analysis of upstream raw materials, downstream demand, and current market dynamics is also carried out. In the end, the report makes some important proposals for a new project of Carbon Black market before evaluating its possibility.\nPrice of Report: $ 4250 (Single User License)\nPurchase Report at https://www.absolutereports.com/purchase/13102197", "domain": "chemistry", "round": 3} +{"url": "https://www.rug.nl/research/portal/publications/instant-ws2-platelets-reorientation-of-selfadaptive-ws2ac-tribocoating(f3418bdf-1331-4569-ba6e-d45114b5cc40).html", "date": "2021-01-23T15:04:44Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-04/segments/1610703538082.57/warc/CC-MAIN-20210123125715-20210123155715-00226.warc.gz", "language_score": 0.8046243786811829, "token_count": 330, "dump": "CC-MAIN-2021-04", "global_id": "webtext-fineweb__CC-MAIN-2021-04__0__246576159", "lang": "en", "text": "Instant WS2 platelets reorientation of self-adaptive WS2/a-C tribocoatingCao, H., Wen, F., De Hosson, J. T. M. & Pei, Y. T., 25-Jun-2018, In : Materials Letters. 229, 2018, p. 64-67 4 p.\nResearch output: Contribution to journal › Article › Academic › peer-review\nWS2/a-C nanocomposite coatings were deposited by magnetron co-sputtering using WS2 and graphite targets. The microstructure and triboperformance of the coatings were scrutinized via microscopy (AFM, SEM, FIB, HRTEM), spectroscopy (XRD, XPS) and tribometry. Atomic WS2 platelets are randomly embedded in an amorphous carbon matrix of the as-deposited nanocomposite coating. HRTEM observations of tribofilm/transfer layer reveal that the sliding contact immediately reorients WS2 platelets parallel to the sliding interface and thereby leads to self-adaptive “frictionless” response. The coefficient of friction falls to 0.02 in dry air and reaches 0.10 in humid air, and is reversible as testing atmosphere cycles between dry air and humid air.\n|Number of pages||4|\n|Publication status||Published - 25-Jun-2018|\n- WS2, Nanocomposites, Magnetron sputtering, Self-adaptation, Reorientation, Self-lubrication\nNo data available", "domain": "chemistry", "round": 3} +{"url": "http://pregi.bi.up.ac.za/pre_gi_swbit.php?blast=blastp&query=NC_007677:1312243&subject=NC_007517:687276", "date": "2021-12-09T04:09:25Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-49/segments/1637964363659.21/warc/CC-MAIN-20211209030858-20211209060858-00597.warc.gz", "language_score": 0.8609898686408997, "token_count": 331, "dump": "CC-MAIN-2021-49", "global_id": "webtext-fineweb__CC-MAIN-2021-49__0__120461911", "lang": "en", "text": "Query: NC_007677:1312243 Salinibacter ruber DSM 13855, complete genome Lineage: Salinibacter ruber; Salinibacter; Rhodothermaceae; Bacteroidetes Order II; Bacteroidetes; Bacteria General Information: This organism is an extremely halophilic aerobe originally isolated from saltern crystallizer ponds in Spain. These bacteria can coexist in significant colonies with halophilic archaea under saline conditions. In contrast to other bacteria they do not regulate their intracellular salt conditions through proton pumps, but instead their protein makeup has adapted to be functional under high ionic conditions.\n- Sequence; - BLASTP hit: hover for score (Low score = Light, High score = Dark); - hypothetical protein; - cds: hover for description\nGeneral Information: First isolated from the Potomac river downstream of Washington, DC, USA in 1987. This organism actively moves towards metal attractants such as iron and manganese oxides, which are insoluble, and produces type IV pili for attachment to the insoluble substrates. Common metal-reducing bacterium. This organism, similar to what is observed in Geobacteria sulfurreducens, couples the oxidation of organic molecules to the reduction of iron by using insoluble Fe (III) as an electron acceptor under anaerobic conditions. This bacterium plays an imporant part of the nutrient cycling in aquatic environments. The cell can also use uranium and plutonium, therefore, this organism and may be important for the bioremediation of contaminated waste sites.", "domain": "chemistry", "round": 3} +{"url": "http://shura.shu.ac.uk/12239/", "date": "2017-04-29T13:32:58Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-17/segments/1492917123491.79/warc/CC-MAIN-20170423031203-00049-ip-10-145-167-34.ec2.internal.warc.gz", "language_score": 0.8349279165267944, "token_count": 515, "dump": "CC-MAIN-2017-17", "global_id": "webtext-fineweb__CC-MAIN-2017-17__0__46452587", "lang": "en", "text": "HARRISON, Patrick L., ABDEL-RAHMAN, Mohamed A., STRONG, Peter, TAWFIK, Mohamed M. and MILLER, Keith (2016). Characterisation of three alpha-helical antimicrobial peptides from the venom of Scorpio maurus palmatus. Toxicon, 117, 30-36.\nMiller Characterisation of three alpha-helical antimicrobial peptides.pdf - Accepted Version\nRestricted to Repository staff only until 31 July 2017.\nAvailable under License All rights reserved.\nDownload (638kB) | Contact the author\nPDF (Acceptance email)\nRestricted to Repository staff only\nDownload (102kB) | Contact the author\nScorpion venoms provide a rich source of anti-microbial peptides. Here we characterise three from the venom of Scorpion maurus palmatus. Smp13 is biologically inactive, despite sharing homology with other antimicrobial peptides, probably because it lacks a typically charged structure. Both Smp-24 and Smp-43 have broad spectrum antimicrobial activity, disrupting bacterial membranes. In addition, there is evidence that Smp24 may inhibit DNA synthesis in Bacillus subtilis. Smp24 haemolysed red blood cells but in contrast, Smp43 was non-haemolytic. The introduction of a flexible Gly-Val-Gly hinge into the middle of Smp24 did not alter the haemolytic activity of Smp24 (as might have been predicted from earlier studies with Pandinin2 (Pin2), although C-terminal truncation of Smp-24 reduced its haemolytic activity, in agreement with earlier Pin 2 studies. Smp24 and its derivatives, as well as Smp-43, were all cytotoxic (ATP release assay) toward mammalian HepG2 liver cells. Our results highlight the beneficial effect of helical-hinge-helical conformation on promoting prokaryotic selectivity of long chain scorpion AMPs, as well as the importance of examining a wide range of mammalian cell types in cytotoxicity testing.\n|Research Institute, Centre or Group:||Biomolecular Sciences Research Centre|\n|Depositing User:||Keith Miller|\n|Date Deposited:||23 May 2016 10:59|\n|Last Modified:||28 Apr 2017 01:38|\nActions (login required)\nDownloads per month over past year", "domain": "chemistry", "round": 3} +{"url": "https://saemobilus.sae.org/content/910455/", "date": "2021-05-06T10:35:48Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-21/segments/1620243988753.91/warc/CC-MAIN-20210506083716-20210506113716-00327.warc.gz", "language_score": 0.8687208890914917, "token_count": 750, "dump": "CC-MAIN-2021-21", "global_id": "webtext-fineweb__CC-MAIN-2021-21__0__147329000", "lang": "en", "text": "This content is not included in your SAE MOBILUS subscription, or you are not logged in.\nSelf-Lubricating Materials for High Temperature Ring/Cylinder Application\nISSN: 0148-7191, e-ISSN: 2688-3627\nPublished February 01, 1991 by SAE International in United States\nAnnotation ability available\nIn support of development efforts for advanced heat engines, self-lubricating materials were evaluated for their friction and wear characteristics above 260 C. The work focused on the ring/cylinder interface and tested self-lubricating ring or cylinder specimens against plasma-sprayed chromia or other ceramic materials. Three materials were chosen for the evaluation. Two of them were solid lubricant compacts, and one was a self-lubricating coating. The compacts were the Westinghouse (Boes) compact and a commercially available molybdenum disulfide-based composite. The coating consisted of a wear-resistant matrix filled with solid lubricating materials to reduce friction. The Boes compact resulted in high temperature friction and wear results that were in some cases equal to or better than those of earlier tests run with liquid lubrication. The other compact and the coating both had much higher wear and coefficients of friction than the Boes compact. The work showed the potential of solid lubricants to lubricate the ring/cylinder interface in low-heat-rejection engines effectively.\nCitationGaydos, P., \"Self-Lubricating Materials for High Temperature Ring/Cylinder Application,\" SAE Technical Paper 910455, 1991, https://doi.org/10.4271/910455.\n- Kamo, R. Bryzik, W. “Cummins/TACOM Advanced Adiabatic Engine” SAE Paper 840428 1984\n- Yoshimitsu, T. Toyama, K. Sato, F. Yamaguchi, H. “Capabilities of Heat Insulated Diesel Engine” SAE Paper 820431 1982\n- Dufrane, K.F. Glaeser, W.A. “Performance of Ceramics in Ring/Cylinder Applications” SAE Paper 870416 1987\n- Dufrane, K.F. Glaeser, W.A. Rosenfield, A.R. “Studies of Dynamic Contact of Ceramics and Alloys for Advanced Heat Engines” 1988\n- Gaydos, P.A. Dufrane, K.F. “Lubrication of Ceramics in Ring/Cylinder Applications” SAE Paper 890888 1989\n- Gaydos, P.A. Dufrane, K.F. “Studies of Dynamic Contact of Ceramics and Alloys for Advanced Heat Engines” Proceedings of the 27th ATD Contractors' Coordination Meeting SAE Publication P-230 1989\n- Boes, D.J. Chamberlain, B. “Chemical Interactions Involved in the Formation of Oxidation-Resistant Solid Lubricant Composites” ASLE Trans. 11 131 139 1968\n- Gardos, M.N. “An Analysis of the Ga/In/WSe 2 Lubricant Compact” ASLE Trans. 28 2 231 238 1984\n- Sliney, H.E. “A New Chromium Carbide-Based Tribological Coating for Use to 900 C with Particular Reference to the Stirling Engine” International Conference on Metallurgical Coatings San Diego, California April 7 11 1986 NASA", "domain": "chemistry", "round": 3} +{"url": "http://healthlands.com.au/product/acetyl-l-carnitine-60-capsules/", "date": "2024-02-24T00:28:51Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707947474470.37/warc/CC-MAIN-20240223221041-20240224011041-00331.warc.gz", "language_score": 0.8549578785896301, "token_count": 251, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__136410591", "lang": "en", "text": "Acetyl L-Carnitine 60 Capsules\nHerbs of Gold Acetyl L-Carnitine contains 500mg of carnitine, an amino acid that supports energy production and muscle performance.\nAcetyl L-Carnitine is a specific form of carnitine that has the ability to cross the blood brain barrier.\nAcetyl L-Carnitine maintains brain and cognitive function and helps the synthesis of neurotransmitters, including acetylcholine.\nAcetyl L-Carnitine supports nerve conduction and nervous system health.\nAcetyl L-Carnitine supports muscle endurance and assists post exercise recovery.\nAcetyl L-Carnitine provides antioxidant activity to reduce free radicals formed in the body.\nAcetyl L-Carnitine supports cardiovascular system health and sperm production and motility.\nEach capsule contains:\nAcetyl levocarnitine hydrochloride (acetyl L-carnitine hydrochloride)\nAdults – Take 2 capsules, once or twice daily, with food, or as directed by your health professional.\nDietary supplements should not replace a balanced diet.", "domain": "chemistry", "round": 3} +{"url": "https://iris.unisalento.it/handle/11587/418931", "date": "2023-01-27T04:21:53Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-06/segments/1674764494936.89/warc/CC-MAIN-20230127033656-20230127063656-00203.warc.gz", "language_score": 0.8934075832366943, "token_count": 384, "dump": "CC-MAIN-2023-06", "global_id": "webtext-fineweb__CC-MAIN-2023-06__0__199357208", "lang": "en", "text": "Colloidal inorganic nanocrystals (NCs) constitute an important class of advanced nanomaterials owing to the flexibility with which their dimensionality-dependent physical–chemical properties can be controlled by engineering their compositional, structural, and geometric features in the synthesis stage and the versatility with which they can be exploited in disparate technological fields, spanning from optoelectronics, energy conversion/production to catalysis, and biomedicine. In recent years, building upon knowledge acquired on the thermodynamic and kinetic processes that underlie NC evolution in liquid media, synthetic nanochemistry research has made tremendous advances, opening new possibilities for designing, creating, and mastering increasingly complex NC-based assemblies, in which sections of different materials are grouped together into free-standing, easily processable multifunctional nanocomposite systems. This chapter will provide an overview of this fast-growing research field by illustrating progress achieved in the wet-chemical development of last-generation breeds of so-called hybrid or heterostructured nanocrystals (HNCs) in asymmetric non-core/shell geometries, in which distinct material modules are interconnected in heterodimer, heterooligomer, and anisotropic multidomain architectures via heteroepitaxial bonding interfaces of limited extension. The focus will be on HNCs that incorporate at least one magnetic material component combined with semiconductors and/or plasmonic metals, which hold potential for generating enhanced, unconventional magnetic behavior, on one side, and diversified or even new properties and capabilities, on the other side. Various synthetic strategies, all based on the manipulation of seeded-growth techniques, will be described and rationally interpreted within the framework of the currently understood mechanisms of colloidal heteroepitaxy.\nFile in questo prodotto:\nNon ci sono file associati a questo prodotto.", "domain": "chemistry", "round": 3} +{"url": "https://www.biopharminternational.com/topic/manufacturing-separation-and-purification?page=2", "date": "2022-09-30T19:17:35Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-40/segments/1664030335504.22/warc/CC-MAIN-20220930181143-20220930211143-00085.warc.gz", "language_score": 0.880389928817749, "token_count": 343, "dump": "CC-MAIN-2022-40", "global_id": "webtext-fineweb__CC-MAIN-2022-40__0__243007795", "lang": "en", "text": "OR WAIT null SECS\n© 2022 MJH Life Sciences and BioPharm International. All rights reserved.\n© 2022 MJH Life Sciences™ and BioPharm International. All rights reserved.\nApril 16, 2021\nSartorius has expanded in the United Kingdom with the relocation to a new facility in Havant, Hampshire, for downstream processing equipment.\nApril 02, 2021\nA series of minute virus of mice spiking studies were performed with a monoclonal antibody product and small-scale AEX membrane adsorbers to evaluate a range of critical processing conditions.\nJanuary 28, 2021\nThe launch of HiScreen Fibro PrismA, the company’s newest product for early mAb purification process development strengthens Cytiva’s new fiber-based Protein A platform.\nJanuary 02, 2021\nThe development of an innovative purification process simplifies downstream processing for biologics.\nDecember 02, 2020\nEstablishing an automated inline dilution system can potentially ease bottlenecking delays resulting from higher upstream yields.\nViral clearance processes and guidance must evolve along with newer biotherapeutic modalities.\nNovember 02, 2020\nContinuous SEC was shown to increase productivity with the same product quality and yield.\nOctober 22, 2020\nThe 6th-generation Eclipse FFF system handles analytes such as proteins, polymers, viruses, gene vectors, and liposomal drug nanoparticles.\nOctober 01, 2020\nA balance must be achieved between debris and impurity removal and maximizing product quality and yield.\nSeptember 01, 2020\nAs technology matures, inefficiencies and process limitations in downstream process chromatography are improved.", "domain": "chemistry", "round": 3} +{"url": "https://pubmed.ncbi.nlm.nih.gov/9525478/?dopt=Abstract", "date": "2020-10-25T20:06:04Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-45/segments/1603107889651.52/warc/CC-MAIN-20201025183844-20201025213844-00510.warc.gz", "language_score": 0.8943708539009094, "token_count": 512, "dump": "CC-MAIN-2020-45", "global_id": "webtext-fineweb__CC-MAIN-2020-45__0__13379344", "lang": "en", "text": "Human polymorphonuclear leukocytes (PMNs) express beta1 integrins that mediate adhesion to extracellular matrix proteins following stimulation with agonists that induce an increase in intracellular calcium. The purpose of these studies was to determine the contribution made by alterations in intracellular calcium ([Ca++]i) to inside-out activation of beta1 integrins using dimethyl sulfoxide (DMSO)-differentiated granulocytic HL60 cells as a model of human PMNs. Activation of beta1 integrins was determined by measuring the expression of an activation-dependent epitope on the beta1 subunit that is recognized by monoclonal antibody (mAb) 15/7. Exposure of granulocytic HL60 cells to calcium ionophore ionomycin (800 nM) alone did not increase the binding of mAb 15/7 to the cell surface, nor did it increase beta1 integrin-mediated adhesion of the cells to fibronectin. Similarly, exposure of the cells to the direct protein kinase C (PKC) activator, dioctanoylglycerol (di-C8) at 100 microM, neither increased binding of mAb 15/7 to these cells nor adhesion to fibronectin. Simultaneous addition of di-C8 and ionomycin, however, caused a significant increase in the expression of the 15/7 epitope and cell adhesion, suggesting synergy between elevating [Ca++]i and stimulating PKC in beta1 integrin activation. Chelation of [Ca++]i with Quin-2 and EGTA reduced both basal (unstimulated) expression of the 15/7 epitope and basal adhesion of granulocytic HL60 cells to fibronectin. In addition, chelation of [Ca++]i caused a significant decrease in 15/7 binding and adhesion stimulated by low (1 ng/ml) concentrations of phorbol myristate acetate (PMA). The inhibitory effect of [Ca++]i chelation on beta1 integrin activation was reversed by repleting [Ca++]i with ionomycin in a Ca++-containing buffer, or by the addition of higher concentrations of PMA (10 ng/ml). These data suggest a role for [Ca++]i in inside-out activation of beta1 integrins, probably through a synergistic effect with PKC activation.", "domain": "chemistry", "round": 3} +{"url": "http://www.abcam.cn/zwilch-antibody-ab101403.html", "date": "2018-01-24T04:10:48Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-05/segments/1516084893300.96/warc/CC-MAIN-20180124030651-20180124050651-00790.warc.gz", "language_score": 0.6940709948539734, "token_count": 360, "dump": "CC-MAIN-2018-05", "global_id": "webtext-fineweb__CC-MAIN-2018-05__0__199582335", "lang": "en", "text": "Recombinant protein fragment contain a sequence corresponding to a region within amino acids 249-460 of Human ZWILCH.\nNT2D1, IMR32, U-87 MG, MCF7\nShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.\nPreservative: 0.01% Thimerosal (merthiolate)\nConstituents: 20% Glycerol, 0.1M Tris, 0.1M Glycine, pH 7\nConcentration information loading...\nImmunogen affinity purified\nAbpromise guarantee covers the use of\nin the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\n1/500 - 1/3000. Predicted molecular weight: 54 kDa.\nEssential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex (PubMed:15824131).\nBelongs to the ZWILCH family.\nChromosome, centromere, kinetochore.\nInformation by UniProt\nhomolog of Drosophila Zwilch antibody\nhas not yet been referenced specifically in any publications.\nPlease note: All products are \"FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE\"", "domain": "chemistry", "round": 3} +{"url": "https://www.slideserve.com/bridie/paper-and-progress-report", "date": "2021-04-17T23:31:22Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-17/segments/1618038464065.57/warc/CC-MAIN-20210417222733-20210418012733-00620.warc.gz", "language_score": 0.7513863444328308, "token_count": 828, "dump": "CC-MAIN-2021-17", "global_id": "webtext-fineweb__CC-MAIN-2021-17__0__119709962", "lang": "en", "text": "Paper and Progress Report Artoni Kevin R. Ang July 1, 2009\nProgress Report • Changed substrate holder • Added a new pair of electrodes and boat holder\nProgress Report • Coated Cr-Cu-Cr mirror (4 designs) • Measured transmission of the Cr-Cu-Cr coatings using the Ocean Optics Spectrophotometer\nThings to do: • Get micrograph of Cr-Cu-Cr mirrors • Schedule FTIR analysis for mirrors • Perform adhesion tests on Cr-Cu-Cr mirrors • Finalize anti-reflection design • Modify evaporation set-up to allow evaporation of new film materials.\nPaper Report • Multilayer antireflection coatings for the visible and near-infrared regions • H. Ganesha Shanbhogue, C. L. Nagendra, M. N. Annapurna, S. Ajith Kumar, and G. K. M. Thutupalli • 1 September 1997 Vol. 36, No. 25 APPLIED OPTICS\nIntroduction • Current research involves improving: • optical performance over a wider spectral range • transmission efficiency • spectral coverage • angle-of-incidence stability • durability • efficiency (residual reflection loss)\nIntroduction • Problems: • AR coatings on a variety of glass substrates • Different indices, chemical compositions, hardness, environmental stability, etc. • Different uses • Residual reflection loss, transmission efficiency, angle of incidence stablity, etc.\nOptical material combinations • MgF2 and medium or high index materials • MgF2 and ZrTi04 and Zr02 (sub2) • MgF2 and Si02, Al2O3, oxides of tantalum, titanium zirconium, and niobium • Sub1 and Ta2O5+SiO2,TiO2+Ta2O5 and SiO2+TiO2\nOptical Material Preparation and Characterization • Sub2 • E-beam evaporation • Base pressure: 10-5 mbar • Added high purity dry oxygen: 10-4 mbar\nOptical Material Preparation and Characterization • Hitachi double-beam spectrophotometer, Model U 3400\nOptical Material Preparation and Characterization • MgF2 • Same fabrication set-up • Substrate temperature: 200°C • 2x10-5 mbar\nOptical Material Preparation and Characterization • Tpeak: transmission peak • A: Cauchy dispersion constant\nOptical Material Preparation and Characterization • MgF2 index of 1.35±0.01 • Literature value of 1.38-1.37\nDesign optimization • Seven layer system of MgF2 and Sub2 coatings in alternate layers • Wideband (WB) AR coatings • Limited band (LB) AR coatings • OPTOSOFT- software to optimize design\nExperimental investigation • Leybold Hereaus vacuum evaporation plant Model 560L • Optically polished and cleaned glass substrates • Substrate temperature: 200 ±5° • Rate: 0.3-0.5 nm/s for MgF2 and 0.05-0.1 nm/s for Sub2\nExperimental investigation • Optical transmittance and reflectance • Durability tests • High-temp. humidity • Thermal shock/ cycling • hot-cold soak.\nConclusions • IRL R*, Rav, ripple Rmax are interlinked to spectral bandwidth. The higher the bandwidth, the higher R*/Rav and the Rmax. 2.Higher-ripple designs can also have global optical properties (R*/Rav and Tav) that are comparable with those of lower-ripple designs but they have higher spectral instability.\nConclusions 3. Sub2 high-index material in combination withMgF2 allows the production of efficient AR coatings with the electron-beam evaporation technique, in terms of both optical properties and durability of the coatings.", "domain": "chemistry", "round": 3} +{"url": "https://www.antikoerper-online.de/abstract/Glutamate+Decarboxylase+2+(Pancreatic+Islets+and+Brain%2C+65kDa)+(GAD2)+ELISA+Kit/", "date": "2018-11-12T17:44:22Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-47/segments/1542039741016.16/warc/CC-MAIN-20181112172845-20181112194845-00107.warc.gz", "language_score": 0.7698125243186951, "token_count": 1451, "dump": "CC-MAIN-2018-47", "global_id": "webtext-fineweb__CC-MAIN-2018-47__0__130788231", "lang": "en", "text": "Use your antibodies-online credentials, if available.\nKeine Produkte auf Ihrer Vergleichsliste.\nIhr Warenkorb ist leer.\nGAD2 encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. Zusätzlich bieten wir Ihnen GAD65 Antikörper (220) und GAD65 Proteine (21) und viele weitere Produktgruppen zu diesem Protein an.\nShowing 8 out of 41 products:\nResults describe the gross distribution patterns of GAD65 in human and rhesus monkey thalami and show that they are nearly identical.\nGAD65 mRNA was found in the periaqueductal gray.\nThis study showed a significant 58% increase of SCN (zeige SRI ELISA Kits) GAD65/67-ir and a significant 169% increase of SCN (zeige SRI ELISA Kits) GAD67 (zeige GAD1 ELISA Kits)-mRNA in the depression group.\nhealthy donor NK cells showed similar degranulation against both GAD65 AA 114-122 pulsed and unpulsed APCs (zeige APCS ELISA Kits). The pathogenetic significance of the CD3 (zeige CD3 ELISA Kits)-CD8dullCD56+ 'memory-like NK cell subset' with increased response upon secondary challenge in diabetics remains to be elucidated\nGenetic variability in GAD2 and GAD1 (zeige GAD1 ELISA Kits) contributes to risk of methamphetamine dependence in the Thai population.\nStudy propose that aberrant accumulation of immunogenic GAD65 in Golgi membranes facilitates inappropriate presentation to the immune system after release from stressed and/or damaged beta-cells, triggering autoimmunity.\nUV exposed hydrogen peroxide produces hydroxyl radical that may cause protein damage (GAD-65) to the extent of generating neo-epitopes on the molecule, making it immunogenic.\nwe investigated the relationship between serum glutamic acid decarboxylase (GAD (zeige GAD ELISA Kits)) autoantibody (Ab) levels and single nucleotide polymorphisms (SNPs) of the glutamic acid de-carboxylase 2 (GAD2) 5'-untranslated region\nGAD (zeige GAD1 ELISA Kits) autoantibodies were associated with risk of developing type 1 diabetes.\nKaplan-Meier survival curves estimated a worst pancreas graft survival for patients with positive IA-2 (zeige PTPRN ELISA Kits) antibodies versus those patients with negative auto-antibodies and GAD65+ auto-antibodies after simultaneous pancreas kidney transplantation.\nPlasma GAD65 qualifies as a marker for early beta-cell loss after intraportal transplantation.\nCohort study shows that mean GAD65 mRNA levels in the prefrontal cortex area 9 are not altered in subjects with schizophrenia but are lower in subjects with schizoaffective disorder\nThese results thus identify a molecularly distinct, orexin (zeige OX ELISA Kits)-activated lateral hypothalamus submodule that governs physical activity in mice.\nResults suggest age-dependent decrease of GAD65/67 mRNAs but normal densities of certain GABAergic interneurons in the Shank3 (zeige SHANK3 ELISA Kits) transgenic mice.\nGABA is the major inhibitory neurotransmitter in the brain. We show that Dlx1/Dlx2 homeobox (zeige PRRX1 ELISA Kits) genes regulate GABA synthesis during forebrain development through direct activation of glutamic acid decarboxylase (zeige GAD ELISA Kits) enzyme isoforms that convert glutamate (zeige GRIN1 ELISA Kits) to GABA.\nTreadmill running prevented partial sciatic nerve ligation-induced reductions in GAD65/67 production, and, thus, GABA levels may be retained in interneurons and neuropils in the superficial dorsal horn.\nIncreased activity due to bicuculline preferentially up-regulated GAD65. This was reduced by AP5, a selective blocker of Ca2 (zeige CA2 ELISA Kits)+-permeable ion channels and NMDA-Rs, and by U0126, KN93, and K252a, affecting BDNF (zeige BDNF ELISA Kits) pathways.\nData show that miRNAs are involved in regulating the expression of the major type 1 diabetes (T1D) autoantigens IA-2 (zeige PTPRN ELISA Kits), IA-2beta (zeige PTPRN2 ELISA Kits), and GAD65 enzyme.\nResults indicate the significant contribution of not only GAD65, GAD67 (zeige GAD1 ELISA Kits) and VGAT (zeige SLC32A1 ELISA Kits)-mediated GABAergic but also glycinergic transmissions to both palate and abdominal wall formations\nAnalysis of GAD65/67 single and double knock-out embryos revealed that the two GADs play complementary (inhibitory) roles in GnRH migration ultimately modulating the speed and/or direction of GnRH migration.\nResults show that GAD65 is required for efficient GABAergic synaptic transmission and plasticity, and for maintaining extracellular GABA at a level needed for associative plasticity at cortical inputs in the lateral amygdala\nMenin regulates spinal glutamate (zeige GRIN1 ELISA Kits)-GABA balance through GAD65 contributing to neuropathic pain.\nThis gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein.\nglutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)\n, glutamate decarboxylase 2\n, glutamic acid decarboxylase\n, 65 kDa glutamic acid decarboxylase\n, Glutamate decarboxylase 2 (islet)\n, glutamate decarboxylase 65 kDa isoform\n, glutamic acid decarboxylase 2\n, glutamic acid decarboxylase 65\n, Glutamate decarboxylase-2 (pancreas)", "domain": "chemistry", "round": 3} +{"url": "https://pubmed.ncbi.nlm.nih.gov/7955533/?dopt=Abstract", "date": "2023-01-29T02:52:57Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-06/segments/1674764499697.75/warc/CC-MAIN-20230129012420-20230129042420-00769.warc.gz", "language_score": 0.9609876871109009, "token_count": 298, "dump": "CC-MAIN-2023-06", "global_id": "webtext-fineweb__CC-MAIN-2023-06__0__137875970", "lang": "en", "text": "ANCA have been demonstrated to induce the respiratory burst in primed neutrophils. In this study we have extended the investigations on neutrophil activation by ANCA directed against proteinase 3 (PR3), myeloperoxidase (MPO) and lactoferrin (LF), and we have analysed the underlying mechanisms. All three ANCA antigens were expressed on the cell surface of primed neutrophils. Superoxide production assayed by both cytochrome c reduction and oxidation of dihydrorhodamine 123, was induced by heterologous polyclonal anti-MPO and anti-LF antibodies, and ANCA-positive plasma samples. Induction of superoxide production was dose-dependent. F(ab')2 fragments did not induce the respiratory burst. Blockade of Fc receptors by specific MoAbs showed that anti-Fc gamma RII antibodies were able to turn off the ANCA-induced respiratory burst, whereas anti-Fc gamma RIII antibodies did not. Plasma samples that induced the respiratory burst did not differ from samples that did not induce superoxide production with respect to ANCA titre, but had higher levels of the IgG3 subclass of ANCA. Levels of the other subclasses of ANCA were comparable between those samples. We conclude that ANCA-induced activation of primed neutrophils is Fc gamma RII-dependent, and appears to be facilitated by antibodies of the IgG3 subclass.", "domain": "chemistry", "round": 3} +{"url": "https://rjptonline.org/AbstractView.aspx?PID=2020-13-12-95", "date": "2022-11-30T19:51:20Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-49/segments/1669446710771.39/warc/CC-MAIN-20221130192708-20221130222708-00516.warc.gz", "language_score": 0.7953327298164368, "token_count": 1745, "dump": "CC-MAIN-2022-49", "global_id": "webtext-fineweb__CC-MAIN-2022-49__0__223290839", "lang": "en", "text": "Chettupalli A K, Padmanabha Rao A, Kuchukuntla M, Bakshi V.\nChettupalli A K*, Padmanabha Rao A, Kuchukuntla M, Bakshi V.\nCentre for Nanomedicine Anurag Group of Institutions, Venkatapur, Ghatkesar, Medchal, Hyderabad-500088, India.\nVolume - 13,\nIssue - 12,\nYear - 2020\nThe main objective of the study is to develop and optimize the potential variables which influence aripiprazole oral disintegration tablets (ODTs) formulation. Aripiprazole ODTs were prepared by using a direct compression method. Three factors with three levels of Box- Behnken design were used to optimize and develop the aripiprazole ODT formulation. The design recommended 20 formulations of different independent variables such as Microcrystalline cellulose (MCC) (X1), Crospovidone (CP) (X2), and Cascarmellose sodium (CCS) (X3) and their effect was monitored on dependent variables such as tablet weight (Y1), Thickness (Y2), Hardness (Y3), Dissolution (Y4), Disintegration (Y5). Agreeable flow properties which are ranged from good to excellent were demonstrated by all powder blends. The disintegration time (Y5) was directly related to the lubricant concentration and mixing of time which intern had a direct effect on tablet thickness, hardness and compression force these interns had a direct impact on friability. The Box-Behnken design recommended an optimized formula of 20mg (X1), 3mg (X2) and 3mg (X3) of the selected independent variables. Finally, the prediction error percentage responses of dependent variables Y1, Y2, Y3, Y4, and Y5 were found to be 0.38, 0.59, 2.43, 4.06, and 3.67% respectively. The 2, 4, and 10 formulas achieved more than 90% of drug release within the seven min of dissolution test time. The optimized formulation of aripiprazole ODT was successfully developed using box Behnken design and the same was prepared efficiently by using the direct compression method.\nCite this article:\nChettupalli A K, Padmanabha Rao A, Kuchukuntla M, Bakshi V. Development and Optimization of Aripiprazole ODT by using box-Behnken Design. Research J. Pharm. and Tech. 2020; 13(12):6195-6201. doi: 10.5958/0974-360X.2020.01080.X\nChettupalli A K, Padmanabha Rao A, Kuchukuntla M, Bakshi V. Development and Optimization of Aripiprazole ODT by using box-Behnken Design. Research J. Pharm. and Tech. 2020; 13(12):6195-6201. doi: 10.5958/0974-360X.2020.01080.X Available on: https://rjptonline.org/AbstractView.aspx?PID=2020-13-12-95\n1. Eslick GD, and Talley NJ. Dysphagia: epidemiology, risk factors, and impact on quality of life--a population-based study. Aliment Pharmacol Ther. (2008) 27: 971–979.\n2. Chen PH, Golub JS, Hapner ER, and Johns MM. Prevalence of perceived dysphagia and quality-of-life impairment in the geriatric population. Dysphagia. (2009) 2: 1–6.\n3. Fu Y, Yang S, Jeong SH, Kimura S and Park K Orally fast disintegrating tablets: developments, technologies, taste-masking, and clinical studies. Crit Rev Ther Drug Carrier Syst. (2004) 21: 433–475.\n4. Mostafa HF, Ibrahim MA, and Sakr A. Development and optimization of dextromethorphan hydrobromide oral disintegrating tablets: effect of formulation and process variables. Pharm Dev Technol. (2013) 18: 454–463.\n5. Late SG, Yu YY and Banga AK. Effects of the disintegration-promoting agent, lubricants and moisture treatment on optimized fast disintegrating tablets. Int J Pharm. (2009) 365: 4–11.\n6. Miller TA. and York P. Pharmaceutical tablet lubrication. Int J Pharm. (1998) 41: 1–19.\n7. Perrault M, Bertrand F and Chaouki J. An investigation of magnesium stearate mixing in a v-blender through gamma-ray detection. Powder Technol. (2010) 200: 234–245.\n8. Fassihi RA, Mcphillips AM, Uraizee SA, and Sakar AM. Potential use of magnesium stearate and talc as dissolution retardants in the development of controlled drug delivery systems. Pharm Ind. (1994) 56: 579–583.\n9. Morin G and Briens L. The effect of lubricants on powder flowability for pharmaceutical application. AAPS Pharm Sci. Tech. (2013) 14: 1158–1168.\n10. Kuno Y, Kojima M, Nakagami H, Yonemochi E and Terada K. Effect of the type of lubricant on the characteristics of orally disintegrating tablets manufactured using the phase transition of sugar alcohol. Eur. J Pharm Biopharm. (2008) 77: 986–992.\n11. Indurwade NH, Rajyaguru TH and Nakhat PD Noval approach-fast dissolving tablets. Indian Drug (2002) 38:405-9.\n12. The United States Pharmacopoeia 29, National Formulary 24,\n13. Asian Edition. Rockville, MD: USPC, Inc; 2006. p. 1890.\n14. Jacob S, Shirwaikar A, Joseph A, and Srinivasan KK. Novel co-processed excipient of mannitol and microcrystalline callous for preparing fast dissolving tablets of Glipizide. Ind J Pharm Sci. (2007) 69:633-9.\n15. Hiremath JG, Shastry CS and Srinath MS. Pharmaceutical approach of taste masking in oral dosage forms. Ind Drug. (2004) 41:253-7.\n16. Abdelbary A, Elshafeey AH and Zidan G. Comparative effects of different cellulosic-based directly compressed or dispersible tablets on oral bioavailability of famotidine. Car Poly (2009).77:799-806.\n17. Sanjeevani S, Deshkar, Arvind Pawara S and Satish Shirolkar V. Formulation and optimization of floating tablets of clopidogrel bisulfate using design of experiments. Int J App Pharm. (2018)10: 94-102.\n18. Yin L, Qin C, Chen K, Zhu C, Cao H, Zhou J, He W and Zhang Q. Gastro-floating tablets of cephalexin: preparation and in vitro/in vivo evaluation. Int J Pharm. (2013) 452:241-8.\n19. Albany AA, Ali WK and Al-Saady FA. Formulation and evaluation of prochlorperazine maleate sustained floating release tablet. Int J Pharm Pharm Sci. (2017) 9:89-98.\n20. Mali AD, and Bathe RS. Development and evaluation of the gastroretentive floating tablet of a quinapril HCl by direct compression technique. Int J Pharm Pharm. Sci. (2017) 9:35-46.", "domain": "chemistry", "round": 3} +{"url": "https://erepo.uef.fi/handle/123456789/7968", "date": "2021-06-17T17:48:22Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-25/segments/1623487630518.38/warc/CC-MAIN-20210617162149-20210617192149-00344.warc.gz", "language_score": 0.7832280397415161, "token_count": 459, "dump": "CC-MAIN-2021-25", "global_id": "webtext-fineweb__CC-MAIN-2021-25__0__80570043", "lang": "en", "text": "Triple Contrast CT Method Enables Simultaneous Evaluation of Articular Cartilage Composition and Segmentation\nSelf archived versionpublished version\nMetadataShow full item record\nCitationHonkanen, MKM. Saukko, AEA. Turunen, MJ. Xu, W. Lovric, G. Honkanen, JTJ. Grinstaff, MW. Lehto, VP. Töyräs, J. (2020). Triple Contrast CT Method Enables Simultaneous Evaluation of Articular Cartilage Composition and Segmentation. Annals of biomedical engineering, 48 (2) , 556-567. 10.1007/s10439-019-02362-6.\nEarly degenerative changes of articular cartilage are detected using contrast-enhanced computed tomography (CT) with a cationic contrast agent (CA). However, cationic CA diffusion into degenerated cartilage decreases with proteoglycan depletion and increases with elevated water content, thus hampering tissue evaluation at early diffusion time points. Furthermore, the contrast at synovial fluid-cartilage interface diminishes as a function of diffusion time hindering accurate cartilage segmentation. For the first time, we employ quantitative dual-energy CT (QDECT) imaging utilizing a mixture of three CAs (cationic CA4+ and non-ionic gadoteridol which are sensitive to proteoglycan and water contents, respectively, and bismuth nanoparticles which highlight the cartilage surface) to simultaneously segment the articulating surfaces and determine of the cartilage condition. Intact healthy, proteoglycan-depleted, and mechanically injured bovine cartilage samples (n = 27) were halved and imaged with synchrotron microCT 2-h post immersion in triple CA or in dual CA (CA4+ and gadoteridol). CA4+ and gadoteridol partitions were determined using QDECT, and pairwise evaluation of these partitions was conducted for samples immersed in dual and triple CAs. In conclusion, the triple CA method is sensitive to proteoglycan depletion while maintaining sufficient contrast at the articular surface to enable detection of cartilage lesions caused by mechanical impact.", "domain": "chemistry", "round": 3} +{"url": "https://www.wallpaper-china.net/stainless-steel-304-double-sphere-rubber-flexible-expansion-joint/", "date": "2023-06-09T14:09:07Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-23/segments/1685224656737.96/warc/CC-MAIN-20230609132648-20230609162648-00606.warc.gz", "language_score": 0.8352770209312439, "token_count": 724, "dump": "CC-MAIN-2023-23", "global_id": "webtext-fineweb__CC-MAIN-2023-23__0__85577447", "lang": "en", "text": "Stainless Metal 304 Double sphere rubber fleXiHu (West Lake) Dis.ble growth joint\n|Content||Stainless steel / rubber|\n1. Organic rubber articles of fifty-3 percent, can proceed to use for fifteen a long time without having getting older.\n2. The thickness of the item, good quality use a lot more safe and durable.\n3. Select 64K metal (say casually) flange.\nfour. fifteen minutes zinc plating, higher stress resistance, higher temperature resistance, oil resistance, use resistance, corrosion resistance, acid and alkali resistance.\nMedium and Application.\nMedium: Freshwater, sewage, seXiHu (West Lake) Dis.Hu (West Lake) Dis.er, air, steam, meals, medicine, oil, acids, etc.\nMunicipal Ballast and bilge technique Chemical processing\nEPTlination EPTs Drilling rigs Drinking water\nDry powder Foods and EPTrage Fuel EPTs\nHAVC Mining sector Pulp and Paper market\nSand dealing with SeXiHu (West Lake) Dis.Hu (West Lake) Dis.er SuXiHu (West Lake) Dis.Hu (West Lake) Dis. sector\nPetroleum and petrochemical Thermo technological drinking water remedy Squander drinking water\nWe value the EPT of our items. Multi-layer EPT helps prevent impurities from adhering to the valve physique and is brougEPT into the media\nFAQ: (Often Requested Inquiries)\nQ: What is your MOQ?\nA: Our MOQ is normally 5 CTNS.\nQ: What is your delivery time?\nA: Excellent in stock: 3-7days\nGreat not in inventory: 20-50days, according to the amount and customization particulars.\nQ: What are your payment terms?\nA: We can acknowledge T/T, L/C, West Union, Paypal and so on.\nQ: Can I have a sample order?\nA: Yes, we welcome sample orEPTto take a look at and check out high quality. Mixed samples are appropriate.\nQ: What’s your solution assortment?\nA: We can source Butterfly valve, Gate valve, World valve, Verify valve, Ball valve, Handle valve, Needle valve, BalXiHu (West Lake) Dis.Hu (West Lake) Dis.ng valve, common valve, Y strainer and so on.\nQ: What certificates can you give?\nA: CE, ISO, WRAS, ACS and so on.\nQ: What stXiHu (West Lake) Dis.Hu (West Lake) Dis.rd of valves can you offer?\nA: ISO, EPT, DIN, JIS, EN, GOST, AS.\nQ: Why pick us?\nA: To begin with, evaluating with numerous factories, our prices are a lot more aggressive.\nNext, We one hundred% check functioning stress for ALL our products, and we examine 5 moments every single purchase.\none) Examine when the ball valves occur out from the injection moulding EPT\n2) Inspect when incorporating O-rings\nthree) Examine when setting up deal with caps\nfour) Inspect right after functioning stress examination\nfive) Inspect just before EPT\nLastly, Following- Services will be very pleased. Any difficulties and feedbacks will be responded efficiently.", "domain": "chemistry", "round": 3} +{"url": "http://www.ask.com/vehicles/fuel-injector-cleaners-really-work-a651fcd93a4cb707", "date": "2015-07-05T15:04:30Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2015-27/segments/1435375097512.42/warc/CC-MAIN-20150627031817-00137-ip-10-179-60-89.ec2.internal.warc.gz", "language_score": 0.9254155158996582, "token_count": 481, "dump": "CC-MAIN-2015-27", "global_id": "webtext-fineweb__CC-MAIN-2015-27__0__30839978", "lang": "en", "text": "Quality fuel injector cleaners that use polyether amine chemistry do clean the fuel lines. The additive also needs to be properly sprayed through the fuel system.Know More\nFuel injectors work by pumping a pressurized amount of fuel into a small opening. Overtime these injectors build up carbon deposits; these deposits disrupt the flow of fuel to and from the engine.\nTwo Common Types of Additives Used in Fuel Injector Cleaners\nPolybutene Amine (PBA)\nPBA is commonly used as an additive in gasoline mixtures. This additive, when used with the recommended dosages, prevent build-up from inside the system. Unfortunately, over-using PBA additives will contribute to carbon deposits inside the engines chambers.\nPolyether Amine (PEA)\nPEA is a higher grade fuel additive that helps maintain combustion chambers. PEA is commonly used in dealership rated fuel system cleaning services.Learn more about Car Parts & Maintenance\nRemove a fuel tank from a car by draining the gasoline, detaching all the fuel lines, disconnecting the rear brake lines and loosening the retaining brackets. If your vehicle is rear-wheel drive, you need to drop the rear suspension. Simplify reinstalling the tank by taking a digital photograph before beginning.Full Answer >\nTo change the fuel filter on a Kia Sportage, disconnect the fuel lines, and replace the old filter with a new filter. You need a floor jack, jack stands, open-end wrenches and a new filter.Full Answer >\nSymptoms of a clogged fuel filter include engine stalling, hard engine start, no engine start, reduced fuel flow, erratic engine performance and decreased fuel consumption. A clogged fuel filter does not properly prevent dirt and debris from entering the fuel delivery system. Dirt and debris can significantly disrupt engine performance.Full Answer >\nFuel injector issues can become apparent with many different symptoms including problems with the car starting, idling problems, a failed emissions test, generally poor car performance and an inability to reach high revolutions per minute, or RPMs. Two major problems exist with the fuel injector. There are bad, faulty, clogged and leaking fuel injectors, which generally cause a decrease in performance, and a leaking fuel injector, which can cause fuel odors within the vehicle as well as poor performance.Full Answer >", "domain": "chemistry", "round": 3} +{"url": "https://www.logiag.com/en/agrology/liming-and-variable-rate-fertilization/", "date": "2024-02-23T06:54:18Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707947474361.75/warc/CC-MAIN-20240223053503-20240223083503-00285.warc.gz", "language_score": 0.8609375953674316, "token_count": 269, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__39567612", "lang": "en", "text": "variable rate fertilization\nWhat is it?\nDepending on where you sample your plot, the profile of your soil can change dramatically. From one end of a field to the other, the pH, nitrogen or phosphorus levels can vary dramatically.\nVariable rate liming or fertilizing allows you to apply the right amount of lime or fertilizer in the right place. This technique is based on precision agriculture, which means data on the various characteristics of your soil (yield, acidity, nitrogen content, etc.) that are georeferenced.\nThis data comes from different sources: field observations, satellites, drones, or public databases. Once grouped on a map, they show you the variations within your fields.\nWhat’s in it for me?\nLiming or fertilizing your fields is an essential practice to keep them fertile and healthy. If you give each area the exact doses of inputs it needs, you get good yields at the best possible cost, while protecting the environment a little better.\nOur in-depth analyses help you evaluate the amount of fertilizer to apply.\nOur agronomists perform in-depth research and analysis to understand the situation in your fields and recommend the right doses of lime and fertilizers to apply on each zone of your fields.\nOur recommendations are compatible with your application files.", "domain": "chemistry", "round": 3} +{"url": "http://sellsteroids.en.made-in-china.com/product/PvjmpHkuagVA/China-Methyldienedione-19-Tren-X-PRO-Dienolone-Tren-Xtreme-One-Tren-Precursors-Trenobol-Prohormone.html", "date": "2017-10-23T10:00:18Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-43/segments/1508187825889.47/warc/CC-MAIN-20171023092524-20171023112524-00325.warc.gz", "language_score": 0.6587442755699158, "token_count": 548, "dump": "CC-MAIN-2017-43", "global_id": "webtext-fineweb__CC-MAIN-2017-43__0__76097183", "lang": "en", "text": "Methyldienedione 19-Tren X PRO-Dienolone, Tren Xtreme One Tren Precursors, Trenobol, Prohormone\nWe are real legit source from China sell the Raw powder anti-estrigen steroid.\nAntiestrogen raw powder of post cycle Legit Real Pure Power!\nFor bodybuilding enhancing, grow muscle, enlarge size, get strength, weight loss\nIf you want to buy, please freely contact me\nClase: Bulk powder; Raw material, Anti-estrogen\nPackage: Discreetly, safe and secure;\nDelivery: Fast, 4~7 days to doorstep, world wide;\nProduct: Fareston API\nQuality standard: USP, Pharmacy (Human) Grade\nGMP, ISO9001 certificate Factory\nToremifene Citrate content: 99.0%min\nProperties: White-to-Off-White Solid\nMelting Point: 160-162 Celcius\nStorage temp. 2-8 Celcius\nMolecular Formula: C32H36ClNO8\nMolecular Weight: 598.08\nClassifications: Antineoplastic; Hormones and synthetic substitutes; Antiestrogen\nDose range and duration of use:\nAverage Reported Dosage: 60-mg daily\nActive half-life: 5 days\nApplication period: 2-16 weeks\nAbsorption: Rapidly absorbed from GI tract. Peak: 3 h.\nDistribution: >99% protein bound; Crosses placenta.\nMetabolism: Metabolized in liver by cytochrome P450 3A4.\nElimination: Excreted primarily in feces.\nToremifene Citrate is the chemical name of active ingredient in Fareston.\nAn antiestrogen and antineoplastic. Nonsteroidal antiestrogen structurally similar to Tamoxifen.\nA first generation nonsteroidal selective estrogen receptor modulator (SERM)\nWe strive to bring you the best Anti Estrogen products on the market, as the real legit source from China for the Raw powder Anti Estrogen steroid:\n-Top quality, large stocks\n-Fast ship within 24hours after you order.\n-Safe Delivery by Express courier, with discreetly package\n-West Union, Moneygram, Bank Wire, Bitcoin capable.\n* * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * *\n|Loss On Drying|| |\n|Conclusion||The specification conform with standard|", "domain": "chemistry", "round": 3} +{"url": "https://www.enplaslifetech.com/tpe-temperature/", "date": "2023-06-06T10:33:37Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-23/segments/1685224652494.25/warc/CC-MAIN-20230606082037-20230606112037-00395.warc.gz", "language_score": 0.9112576246261597, "token_count": 408, "dump": "CC-MAIN-2023-23", "global_id": "webtext-fineweb__CC-MAIN-2023-23__0__228422996", "lang": "en", "text": "Temperature and Sealing with TPEs\nSome life science applications may require that thermoplastic elastomer (TPE) fluid seals go through thermal cycling for a fixed period. When choosing a TPE for an application, it is important to consider the operating temperature of the material in regard to the application. If TPEs are subjected to temperatures outside their service temperature range (as defined by material manufacturers), they may undergo changes that will affect sealing performance.\n- High temperature: At elevated temperatures, TPEs could initially become softer which could affect the fluid seal. If the exposure is short term, the hardness could return to its original state when cooled down. Depending on the material, there are critical temperatures and length of exposure that would permanently change the TPE’s chemical composition. Effects could include inflation, compression set, and hardening. There are medical grade TPEs known to endure the thermocycling of PCR, temperature reaching above 90°C (194°F) or higher (up to around 130°C [around 270°F] for autoclave).\n- Low temperature: If temperatures are lower than the material service range, TPEs may harden but will mostly revert to their original characteristics when restored to room temperature. This effect should be considered if the fluid seal must remain intact during cryogenic storage.\nFor over 20 years, Enplas Life Tech has worked with industry leading clients to solve challenging TPE manufacturing problems, resulting in robust prototypes and industrial-scale manufacturing of the final product. With dedication to meticulous design review and engineering, tool building, injection molding, and assembly, Enplas Life Tech will help you speed up product development and accurately manufacture your fluid-sealing interface.\nComplex shapes, small features, intense pneumatic pressures—manufacturing a stable fluid-sealing interface can be complicated. Download our TPE fluid-sealing guide to learn how Enplas Life Tech can help.", "domain": "chemistry", "round": 3} +{"url": "http://www.invention-ifia.ch/suzhou/Hungary1/Milankovics.htm", "date": "2018-01-16T13:43:17Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-05/segments/1516084886436.25/warc/CC-MAIN-20180116125134-20180116145134-00216.warc.gz", "language_score": 0.8780458569526672, "token_count": 290, "dump": "CC-MAIN-2018-05", "global_id": "webtext-fineweb__CC-MAIN-2018-05__0__150149898", "lang": "en", "text": "preventive pharmaceutical compositions\nThe problem the inventor(s) wanted to solve\nalterations of the vaginal flora are frequent and their consequences are\nremarkable but the mono therapies presently applied are not effective enough.\nCombined treatment is a significantly more effective method than the mono\ncompositions according to the invention make possible the combination of (i)\nbactericide (for aerobic and anaerobic bacteria), involving anti-Mobiluncus\nand anti-Gardnerella, and (ii) fungicide and (iii) anti-protozoa effect\nsimultaneously. Moreover, they have an additional antiviral effect included\nbasis of the invention is the discovery that a unique combination of active\ningredients has numerous advantages over the art. In a preferred embodiment,\nthe invention relates to compositions comprising a) an antibiotic, b)\nsulphonamide c) antifungal component, and d) 5-nitro-imidazoles and a\npharmaceutically acceptable carrier.\ninvention relates to novel pharmaceutical compositions and their uses as\nsuppositories, especially vaginal suppositories, ointments, vaginal drops and\ntalc powders, and painting solutions.\ncombined treatment is simultaneously effective in cases of the most prevalent\ninfections and co-infections.\nStage of development.\nsuppositories produced by pharmacies. Clinical trials are progress.", "domain": "chemistry", "round": 3} +{"url": "https://www.changinghands.com/book/9781801444675", "date": "2021-06-16T14:04:15Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-25/segments/1623487623942.48/warc/CC-MAIN-20210616124819-20210616154819-00456.warc.gz", "language_score": 0.9398322105407715, "token_count": 310, "dump": "CC-MAIN-2021-25", "global_id": "webtext-fineweb__CC-MAIN-2021-25__0__50228321", "lang": "en", "text": "Hormones are your body's chemical messengers. Produced in the endocrine glands, these powerful chemicals travel around your bloodstream telling tissues and organs what to do. They help control many of your body's major processes, including metabolism and reproduction.\nWhen you have a hormonal imbalance, you have too much or too little of a certain hormone. Even tiny changes can have serious effects throughout your whole body.\nThink of hormones like a cake recipe. Too much or too little of any one ingredient affects the final product. While some hormone levels fluctuate throughout your lifetime and may just be the result of natural aging, other changes occur when your endocrine glands get the recipe wrong.\nYour hormones play an integral role in your overall health. Because of that, there's a broad range of symptoms that could signal a hormonal imbalance. Your symptoms will depend on which hormones or glands aren't working properly.\nStatistics show that hormonal imbalances, especially in women, are much more common than thought previously. You might not be able to see a hormonal imbalance, but its effects can present themselves in all aspects of your life and, left untreated, can be dangerous or even life-threatening. So with the prevalence of a hormone imbalance being so high, why don't more of us seek medical treatment? First, it helps to know what a hormone does, and why left untreated, it can be dangerous.\nDo you want to know more?\nThen Scroll up, click on \"Buy now with 1-Click\", and Get Your Copy Now", "domain": "chemistry", "round": 3} +{"url": "https://www.unboundmedicine.com/medline/citation/6613459/Renal_oxygenation_and_lactate_metabolism_in_hemorrhagic_shock_in_dogs_", "date": "2022-09-29T04:23:45Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-40/segments/1664030335304.71/warc/CC-MAIN-20220929034214-20220929064214-00689.warc.gz", "language_score": 0.9354782104492188, "token_count": 263, "dump": "CC-MAIN-2022-40", "global_id": "webtext-fineweb__CC-MAIN-2022-40__0__113284694", "lang": "en", "text": "Renal oxygenation and lactate metabolism in hemorrhagic shock in dogs.Acta Chir Scand. 1983; 149(3):239-44.AC\nRenal tissue oxygen tension and lactate metabolism were studied in hemorrhagic shock in dogs. The renal tissue PO2 and oxygen consumption declined in proportion to blood loss and decreasing blood flow. The decrease of tissue PO2 was greater in the cortex than in the medulla. Renal lactate uptake remained constant at the control level until 30% blood loss through an increase of renal arteriovenous lactate difference in direct proportion to arterial lactate concentration. During hemorrhagic shock after 40% blood loss lactate uptake decreased sharply and ceased almost totally. Before shock renal lactate uptake correlated highly significantly with arterial pH whereas after shock the correlation between these parameters was less significant. After reinfusions of shed blood the renal tissue PO2 returned to the prehemorrhage level in both tissue layers despite the reduced renal blood flow. At this phase renal oxygen consumption and lactate uptake failed to reach the control levels. These findings indicate that in moderate hypotension renal lactate uptake is not restricted by the local oxygen supply. During established shock tissue hypoperfusion and hypoxia seem to be responsible for deterioration of renal lactate metabolism.", "domain": "chemistry", "round": 3} +{"url": "https://www.beilstein-journals.org/bjoc/authors?a=Bakhonsky,%20Vladyslav", "date": "2022-08-13T10:19:19Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571911.5/warc/CC-MAIN-20220813081639-20220813111639-00075.warc.gz", "language_score": 0.686389148235321, "token_count": 499, "dump": "CC-MAIN-2022-33", "global_id": "webtext-fineweb__CC-MAIN-2022-33__0__14711927", "lang": "en", "text": "1 article(s) from Bakhonsky, Vladyslav\nSynthesis of 2-unsubstituted imidazole N-oxides 1 from α-hydroxyiminoketones 2 and formaldimines 3.\nJump to Scheme 1\nPreparation of adamantyloxyamine (4) and its conversion into N-(adamantyloxy)formaldimine (6a); Ad ...\nJump to Scheme 2\nSynthesis of 1-(adamantyloxy)imidazole 3-oxides 7a–e and 1-adamantylimidazole 3-oxides 7f,g in acet...\nJump to Scheme 3\nDeoxygenation of 1-(adamantyloxy)imidazole 3-oxides 7a–d and isomerization of 7b into imidazole-2-o...\nJump to Scheme 4\nConversions of imidazole 3-oxides 7a–d into 1-(adamantyloxy)imidazole-2-thiones 10a–d via sulfur tr...\nJump to Scheme 5\nSyntheses of the non-symmetric 1,3-dialkoxyimidazolium bromides 13a–c and 1-alkyl-3-alkoxyimidazoli...\nJump to Scheme 6\nAttempted O-adamantylation of imidazole N-oxide 7a with adamantan-1-yl trifluoroacetate and subsequ...\nJump to Scheme 7\nSynthesis of the symmetric 1,3-di(adamantyloxy)imidazolium bromide (15) and its transformation to 1...\nJump to Scheme 8\nBeilstein J. Org. Chem. 2019, 15, 497–505, doi:10.3762/bjoc.15.43\nSubscribe to our Latest Articles RSS Feed.\nRegister and get informed about new articles.\nFollow the Beilstein-Institut", "domain": "chemistry", "round": 3} +{"url": "https://standards.globalspec.com/std/1165209/astm-d6047", "date": "2019-10-17T01:19:14Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-43/segments/1570986672431.45/warc/CC-MAIN-20191016235542-20191017023042-00148.warc.gz", "language_score": 0.8806366920471191, "token_count": 268, "dump": "CC-MAIN-2019-43", "global_id": "webtext-fineweb__CC-MAIN-2019-43__0__119558292", "lang": "en", "text": "Standard Test Methods for Rubber, Raw—Determination of 5-Ethylidenenorbornene (ENB) or Dicyclopentadiene (DCPD) in Ethylene-Propylene-Diene (EPDM) Terpolymers\n|Publication Date:||10 May 1999|\n|ICS Code (Rubber):||83.060|\nThese test methods cover the determination of the content of\nENB and DCPD are dienes introduced in ethylene/ propylene rubbers to generate specific cure properties. Since high precision for diene content determination has become very important, a Fourier Transform Infrared Spectroscopic (FTIR) method was developed. Diene determination was performed in the past by a refractive index technique.\nNOTE 1-The procedures for % ENB and % DCPD differ only in the location in the infrared (IR) of the IR peak being quantified.\nThe values stated in SI units are to be regarded as standard. No other units of measurement are included in this standard.\nThis standard does not purport to address all of the safety concerns, if any, associated with its use. It is the responsibility of the user of this standard to establish appropriate safety and health practices and determine the applicability of regulatory limitations prior to use.", "domain": "chemistry", "round": 3} +{"url": "https://losoonmall.com/product/2-x-california-aloe-vera-cleansing-tissues-160-sheets-nature-republic/", "date": "2021-06-22T08:29:34Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-25/segments/1623488512243.88/warc/CC-MAIN-20210622063335-20210622093335-00546.warc.gz", "language_score": 0.708452045917511, "token_count": 409, "dump": "CC-MAIN-2021-25", "global_id": "webtext-fineweb__CC-MAIN-2021-25__0__57303112", "lang": "en", "text": "2 x CALIFORNIA ALOE VERA CLEANSING TISSUES\nOur California Aloe Vera Cleansing Tissues are facial tissues with Aloe Vera from California that cleanses and moisturises the skin.\n- Soft cleansing tissue with water base\n- Washing your is necessary part of skincare\n- For all skin types\n- Use a sheet to gently sweep over face to remove makeup and impurities.\n- Use cleansing water to finish.\n- Soothing effect\n- It is effective in treating wounds.\nVolume: 80 sheets per pack\nFor external use only. Avoid contact with eyes. In case of contact with eyes, rinse thoroughly with water. Inform your doctor if an adverse reaction occurs. Discontinue use if signs of irritation or rashes appear. Keep out of reach of children. Replace cap after use.\nIngredients: AQUA, ALCOHOL, BUTYLENE GLYCOL, PEG-400, ALOE BARBADENSIS LEAF POWDER, CHAMOMILLA RECUTITA FLOWER/LEAF EXTRACT, DIPOTASSIUM GLYCYRRHIZATE, DISODIUM EDTA, ETHYLHEXYLGLYCERIN, JASMINUM OFFICINALE EXTRACT, LAVANDULA ANGUSTIFOLIA EXTRACT, LIPPIA CITRIODORA LEAF EXTRACT, MALTODEXTRIN, MARIS AQUA, MENTHA PIPERITA LEAF EXTRACT, PANTHENOL, PARFUM, PEG-40 HYDROGENATED CASTOR OIL, PEG-7 GLYCERYL COCOATE, ROSMARINUS OFFICINALIS LEAF EXTRACT, PHENOXYETHANOL, SODIUM BENZOATE, BUTYLPHENYL METHYLPROPIONAL, LINALOOL", "domain": "chemistry", "round": 3} +{"url": "https://manufacturingpa.org/projects/2020/southwest/improving-3d-binder-jet-printed.html", "date": "2024-04-23T07:32:14Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712296818468.34/warc/CC-MAIN-20240423064231-20240423094231-00343.warc.gz", "language_score": 0.9275093078613281, "token_count": 383, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__48508865", "lang": "en", "text": "Principal investigator: Markus Chmielus\nUniversity: University of Pittsburgh\nIndustry partners: General Carbide\nThe tungsten carbide industry produces parts used in many high demand applications, including tooling for wear, as well as finishing parts and metal forming. The traditional powder forming processes that are used in the industry are limited in their ability to produce highly complex parts. To circumvent drawbacks to traditional subtractive manufacturing, additive manufacturing (AM) methods have been increasingly adopted into other industries, making the production of highly complex metal parts a possibility. Laser-based AM methods are commonly used but can be problematic because of large thermal gradients associated with repeated rapid heating and cooling. High thermal gradients are especially detrimental to tungsten carbide, causing cracking and premature failure. As a result, it is crucial to investigate a different AM method for producing highly complex tungsten carbide parts. Binder jet 3D printing (BJ3DP) is a non-laser-based method of AM that uses a binder to selectively join powder layer-by-layer, creating parts that are then pressure-sintered to achieve full density, eliminating heat-induced cracking. The previous study has exposed additional challenges, such as a need to tailor the powder before printing, and to develop process and binder modifications to increase the density of the printed parts prior to sintering. The proposed project of General Carbide Corporation and the Chmielus’s group at the University of Pittsburgh will address challenges associated with achieving high density parts to meet the mechanical property and shape change requirements of General Carbide. Success of this project will increase the competitive edge of General Carbide over international competitors and increase their capabilities to produce highly complex parts and low-count batches of parts. This project also allows for two female students to perform fundamental and applied research while directly engaging with a local PA company.", "domain": "chemistry", "round": 3} +{"url": "http://tw.sinobiological.com/Human-DNMT2-TRDMT1-Gene-cDNA-Clone-(full-length-ORF-Clone),-expression-ready,-N-FLAG-tagged_p52761.html", "date": "2017-04-27T18:45:03Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-17/segments/1492917122619.71/warc/CC-MAIN-20170423031202-00134-ip-10-145-167-34.ec2.internal.warc.gz", "language_score": 0.7034992575645447, "token_count": 1448, "dump": "CC-MAIN-2017-17", "global_id": "webtext-fineweb__CC-MAIN-2017-17__0__117216424", "lang": "en", "text": "|Vector Type||Mammalian Expression Vector|\n|Expression Method||Constiutive, Stable / Transient|\n|Selection In Mammalian Cells||Hygromycin|\nFLAG-tag, or FLAG octapeptide, is a polypeptide protein tag that can be added to a protein using recombinant DNA technology. It can be used for affinity chromatography, then used to separate recombinant, overexpressed protein from wild-type protein expressed by the host organism. It can also be used in the isolation of protein complexes with multiple subunits.\nA FLAG-tag can be used in many different assays that require recognition by an antibody. If there is no antibody against the studied protein, adding a FLAG-tag to this protein allows one to follow the protein with an antibody against the FLAG sequence. Examples are cellular localization studies by immunofluorescence or detection by SDS PAGE protein electrophoresis.\nThe peptide sequence of the FLAG-tag from the N-terminus to the C-terminus is: DYKDDDDK (1012 Da). It can be used in conjunction with other affinity tags, for example a polyhistidine tag (His-tag), HA-tag or Myc-tag. It can be fused to the C-terminus or the N-terminus of a protein. Some commercially available antibodies (e.g., M1/4E11) recognize the epitope only when it is present at the N-terminus. However, other available antibodies (e.g., M2) are position-insensitive.\n|人 DNMT2 / TRDMT1 基因全長cDNA ORF克隆 (表達載體), C-GFPSpark 標籤||HG11224-ACG|\n|人 DNMT2 / TRDMT1 基因全長cDNA ORF克隆 (表達載體), C-OFPSpark 標籤||HG11224-ACR|\n|人 DNMT2 / TRDMT1 基因全長cDNA ORF克隆 (表達載體), N-GFPSpark 標籤||HG11224-ANG|\n|人 DNMT2 / TRDMT1 基因全長cDNA ORF克隆 (表達載體), N-OFPSpark 標籤||HG11224-ANR|\n|人 DNMT2 / TRDMT1 基因全長cDNA ORF克隆 (表達載體), C-Flag 標籤||HG11224-CF|\n|人 DNMT2 / TRDMT1 基因全長cDNA ORF克隆 (表達載體), C-His 標籤||HG11224-CH|\n|人 DNMT2 / TRDMT1 基因全長cDNA ORF克隆 (表達載體), C-Myc 標籤||HG11224-CM|\n|人 DNMT2 / TRDMT1 基因全長cDNA ORF克隆 (表達載體), C-HA 標籤||HG11224-CY|\n|人 DNMT2 / TRDMT1 基因全長cDNA ORF(克隆載體)||HG11224-M|\n|人 DNMT2 / TRDMT1 基因全長cDNA ORF克隆 (表達載體), N-Flag 標籤||HG11224-NF|\n|人 DNMT2 / TRDMT1 基因全長cDNA ORF克隆 (表達載體), N-His 標籤||HG11224-NH|\n|人 DNMT2 / TRDMT1 基因全長cDNA ORF克隆 (表達載體), N-Myc 標籤||HG11224-NM|\n|人 DNMT2 / TRDMT1 基因全長cDNA ORF克隆 (表達載體), N-HA 標籤||HG11224-NY|\n|人 DNMT2 / TRDMT1 基因全長cDNA ORF克隆 (表達載體)||HG11224-UT|\nDNMT2, also known as tRNA (cytosine-5-)-methyltransferase, DNA methyltransferase homolog HsaIIP, and TRDMT1, is a member of the DNA methyltransferase family of enzymes. DNMT2 enzymes have been widely conserved during evolution and contain all of the signature motifs of DNA (cytosine-5)-methyltransferases. It contains all 10 sequence motifs that are conserved among m(5)C MTases, including the consensus S:-adenosyl-L-methionine-binding motifs and the active site ProCys dipeptide, and its structure is very similar to prokaryotic DNA methyltransferases. DNMT2 has close homologs in plants, insects and Schizosaccharomyces pombe, but no related sequence can be found in the genomes of Saccharomyces cerevisiae or Caenorhabditis elegans. While the biological function of DNMT2 is not yet known, the strong binding to DNA suggests that DNMT2 may mark specific sequences in the genome by binding to DNA through the specific target-recognizing motif. However, the DNA methyltransferase activity of these proteins is comparatively weak and their biochemical and functional properties remain enigmatic. Recent evidence now shows that Dnmt2 has a novel tRNA methyltransferase activity, raising the possibility that the biological roles of these proteins might be broader than previously thought.", "domain": "chemistry", "round": 3} +{"url": "https://www.cellsignal.com/product/productDetail.jsp?productId=2345", "date": "2018-04-19T11:57:27Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-17/segments/1524125936914.5/warc/CC-MAIN-20180419110948-20180419130948-00422.warc.gz", "language_score": 0.8890553712844849, "token_count": 475, "dump": "CC-MAIN-2018-17", "global_id": "webtext-fineweb__CC-MAIN-2018-17__0__164478480", "lang": "en", "text": "Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.\nChk1 Antibody detects endogenous levels of total Chk1 protein.\nPolyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ser296 of human Chk1. Antibodies are purified by protein A and peptide affinity chromatography.\nChk1 kinase acts downstream of ATM/ATR kinase and plays an important role in DNA damage checkpoint control, embryonic development, and tumor suppression (1). Activation of Chk1 involves phosphorylation at Ser317 and Ser345 by ATM/ATR, followed by autophosphorylation of Ser296. Activation occurs in response to blocked DNA replication and certain forms of genotoxic stress (2). While phosphorylation at Ser345 serves to localize Chk1 to the nucleus following checkpoint activation (3), phosphorylation at Ser317 along with site-specific phosphorylation of PTEN allows for re-entry into the cell cycle following stalled DNA replication (4). Chk1 exerts its checkpoint mechanism on the cell cycle, in part, by regulating the cdc25 family of phosphatases. Chk1 phosphorylation of cdc25A targets it for proteolysis and inhibits its activity through 14-3-3 binding (5). Activated Chk1 can inactivate cdc25C via phosphorylation at Ser216, blocking the activation of cdc2 and transition into mitosis (6). Centrosomal Chk1 has been shown to phosphorylate cdc25B and inhibit its activation of CDK1-cyclin B1, thereby abrogating mitotic spindle formation and chromatin condensation (7). Furthermore, Chk1 plays a role in spindle checkpoint function through regulation of aurora B and BubR1 (8). Research studies have implicated Chk1 as a drug target for cancer therapy as its inhibition leads to cell death in many cancer cell lines (9).\nCell Signaling Technology is a trademark of Cell Signaling Technology, Inc.\nExplore pathways related to this product.", "domain": "chemistry", "round": 3} +{"url": "http://www.chemspider.com/ibcontent.ashx?csid=570989&type=eplatform&category=Books", "date": "2021-04-15T22:50:53Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-17/segments/1618038088264.43/warc/CC-MAIN-20210415222106-20210416012106-00327.warc.gz", "language_score": 0.6679982542991638, "token_count": 330, "dump": "CC-MAIN-2021-17", "global_id": "webtext-fineweb__CC-MAIN-2021-17__0__126303230", "lang": "en", "text": "to explore results)\n- Unravelling Single Cell Genomics: Micro and Nanotools, Chapter 4 Understanding Cellular Differentiation.\n, Pages 36-44\n- Manganese in Health and Disease, Chapter 17 The Effects of Manganese on Female Pubertal Development.\n, Pages 437-458\n- New Horizons in Predictive Drug Metabolism and Pharmacokinetics, CHAPTER 14 Induction of Hepatic Cytochrome P450 Enzymes: Importance in Drug Development and Toxicity.\n, Pages 309-332\n- Drug Discovery for Schizophrenia, CHAPTER 2 The Impact of Epigenetics in Schizophrenia Research.\n, Pages 28-45\n- Sustainable Catalysis: With Non-endangered Metals, Part 1, Chapter 6 Titanium-based Catalysts for Polymer Synthesis.\n, Pages 116-139\n- Carbon Capture and Storage, Chapter 1 Introduction – Carbon Capture and Storage.\n, Pages 1-7\n- Anti-Inflammatory Drug Discovery, CHAPTER 2 Inhibitors of Cytosolic Phospholipase A2\nα as Anti-inflammatory Drugs.\n, Pages 35-57\n- Chirality from Dynamic Kinetic Resolution, Chapter 1 Chiral Auxiliaries\n, Pages 1-48\n- Biotherapeutics: Recent Developments using Chemical and Molecular Biology, CHAPTER 5 Synthetic Protein Biologics.\n, Pages 130-144\n- Drug Discovery for Psychiatric Disorders, CHAPTER 11 Modulation of HPA Axis Function for Treatment of Mood Disorders.\n, Pages 276-299", "domain": "chemistry", "round": 3} +{"url": "https://instrukart.ke/product/hanna-hi8410-dissolved-oxygen-controller/", "date": "2023-03-21T04:49:42Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-14/segments/1679296943625.81/warc/CC-MAIN-20230321033306-20230321063306-00340.warc.gz", "language_score": 0.825524628162384, "token_count": 1002, "dump": "CC-MAIN-2023-14", "global_id": "webtext-fineweb__CC-MAIN-2023-14__0__53431931", "lang": "en", "text": "Hanna HI8410 Dissolved Oxygen controller\nHanna HI8410 Dissolved Oxygen controller is a dissolved oxygen controller mounted on a panel that is used in a wide range of industrial process applications to manage and monitor DO concentration.\nApplications: In Industrial process applications to manage and monitor DO concentration.\nHanna HI8410 Dissolved Oxygen controller designed for ease of use in various applications for industrial processes. In compliance with the selection switch on the back panel, dissolved oxygen is indicated in mg / L (ppm) or as a percentage of saturation. The temperature effects on oxygen solubility and membrane permeability are automatically accounted for by the Dissolved Oxygen readings. In saline waters, the salinity compensation feature allows Dissolved Oxygen to be measured. The instruments are fitted with a regular DIN panel mount with membrane keypads and a large front-light LCD with auto-diagnostic features. Screw terminals on the rear panel connect the probes, the power supply, the contacts, and the recorders.\nFeatures of Hanna Dissolved Oxygen controller:\n- The exclusive Hanna Fail, Safe alert system defends against issues that are common threats in industrial environments triggered by power supply loss or signal interference. A red LED, placed directly on the front panel of the controller, signals the warning state.\n- The temperature effects on oxygen solubility and membrane permeability are automatically compensated by the Dissolved Oxygen readings.\n- In saline waters, the salinity compensation function helps Dissolved Oxygen to be calculated.\n- Simply attach a recording unit to the instrument’s 4 to 20 mA output contacts, conveniently placed on the front panel, to boost troubleshooting and the ability to capture data while tracking, and receive a copy of the findings on request.\n- The HI 8410 controllers are equipped with integrated diagnostic functions to allow the instrument to be tested and troubleshot by the user. The tests conducted are carried out by the front panel keys which can be used to isolate the cause of failure.\n|Dissolved Oxygen Measurement Type||\nGalvanic: HI76410/4 with 4 m (13.1’) cable or HI76410/10 with 10 m (32.8’) cable (not included )\n0.0 to 50.0 mg/L (ppm) O₂; 0 to 600 % O\n±1% of reading (O₂)\n0.1 mg/L (ppm) or 1% (O₂)\nManual, one point, in saturated air\n|Dissolved Oxygen Temperature Compensation||\nAutomatic, from -5 to 50 °C (23 to 122 °F)\n0 to 51 g/L (resolution 1 g/L)\n|Dissolved Oxygen Dosing Relay||\n1, isolated, 2A, max. 240V, resistive load, 1,000,000 strokes\n|Dissolved Oxygen Dosing Set Point||\n5 to 600 % O2 0.5 to 50.0 mg/L (ppm) O2\n|Dissolved Oxygen Hysteresis Band||\n0.5 to 2.4 mg/L (ppm) O2\nOFF/AUTO/ON with selection switch\n|Alarm Relay Range||\n1.0 to 5.0 mg/L (ppm) O₂\n|Over Dosing Control||\nAdjustable, from 5 min to 60 min with a knob or Disable by wire strap – on real panel\nBlack anodized aluminum body; front and back with ABS; transparent splash-proof front cover\n141 x 69 mm\nHI 76410/4 with 4 m cable or HI 76410/10 with 10 m cable\n115 or 230 Vac; ± 10% (user selectable); 60/50 Hz\n0 to 20 mA or 4 to 20 mA (isolated)\n-10 to 50 °C (14 to 122 °F); RH 95%\nThere are no reviews yet.", "domain": "chemistry", "round": 3} +{"url": "https://www.anabolic-steroidhormones.com/sale-10163980-drostanolone-propionate-weight-loss-steroids-50mg-100mg-each-day-dosage.html", "date": "2023-03-21T19:48:38Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-14/segments/1679296943746.73/warc/CC-MAIN-20230321193811-20230321223811-00514.warc.gz", "language_score": 0.9063150882720947, "token_count": 884, "dump": "CC-MAIN-2023-14", "global_id": "webtext-fineweb__CC-MAIN-2023-14__0__165267911", "lang": "en", "text": "Payment & Shipping Terms:\n|Dosage:||50-100mg Each Day||Use:||Avoid Water Retention|\nraw hormone powders,\nMasteron is an injectable anabolic steroid that is a DHT (dihydrotestosterone) derivative. Often slanged as Mastabol, Mast, or Masto, Masteron is generally available as – Drostanolone Propionate and Drostanolone Enanthate. Masteron is chemically structured as 2a-methyl-androstan-3-one-17b-ol. Masteron Propionate is usually dosed at 50-150mg/ml. It is very popular and favorite amongst the bodybuilders due to its extraordinary characteristics. It has ability to improve the muscle hardness and density due to the androgenic properties.\nMasteron Propionate is fast acting anabolic steroids, and thus it is often required to be injected every other day. It acts very fast and breaks down very quickly, so the athlete can have the benefit of Masteron Propionate, using it ten days before the drug test. Masteron Propionate is good for the athletes who want to avoid water retention and who have a problem with an elevated estrogen level.Bodybuilders go for this drug because this is beneficial for them as it doesn’t convert itself into estrogen which causes water retention; this gives the muscles a smooth appearance. The androgenic properties of Masteron propionate also help to boost the energy levels for intense training in athletes.\nThe reason that bodybuilders are such large users of the drug is due to it’s anabolic\nDHT, from what Masteron derives, is five times more androgenic (androgens are male hormones) than testosterone and is much more likely to bind to the androgen receptors. Due to this, DHT makes muscles look hard and dense as well as promoting fat loss through boosting the metabolic rate or directly causing lipolysis (the breakdown of lipids/fat).\nStacking and Use:\nBest use is to inject 50-100 mg every day to every other day, depending on your degree of expertise in training and your size of course. Most beginners will be quite satisfied with either 50 mg every other day or 100 mg every 3 days. Mostly used in conjunction with other drugs as DHT is quite easily de-activated in the body\nAlthough its rare that someone opts for a stack of two compounds with largely similar action, something can be said about stacking drostanolone with Stanazolol (Winstrol/stromba).\nDrostanolone is best stacked with something in the nature of boldenone (Equipoise) at 300 mg a week. The boldenone gives increased vascularity and the drostanolone adds muscle density while the stack as a whole preserves muscle mass.The drostanolone doesn't stay active at the AR very much, often being drawn to SHBG, albumin, aromatase or 3bHSD, but still adds distinct hardness and boosts strength to some degree.\nMasteron can increase muscle mass and cause a positive nitrogen balance. The body mass is increased gradually over a period of 4-6 weeks.\nMasteron does not undergo aromatization to estrogen and that is why it was preferred to many of the other anabolic steroids. It resembles testosterone in its actions.\nOur Services for you\n|Quality||We are wholesale , The quality are Guarantee|\n|Shipping Method||DHL, Fedex, EMS , HKEMS , EUB , TNT, Choose the best one to ship package|\n|Packing||Many kinds of packing way|\n|Customized||Oils , peptides , Labels , Caps, Pills , etc .|\n|Payment||Money Gram, T/T , Western Union , Paypal|\n|Package picture||After confirm the funds, within 12hours|\n|Tracking Number||Within 48hours|", "domain": "chemistry", "round": 3} +{"url": "https://spoel.bio.ed.ac.uk/Redox.html", "date": "2021-12-05T20:28:28Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-49/segments/1637964363216.90/warc/CC-MAIN-20211205191620-20211205221620-00624.warc.gz", "language_score": 0.901010274887085, "token_count": 718, "dump": "CC-MAIN-2021-49", "global_id": "webtext-fineweb__CC-MAIN-2021-49__0__201308635", "lang": "en", "text": "Redox changes are associated with the cell’s response to environmental stress cues. These changes are thought to contain information for down stream signaling processes that lead to transcription reprogramming. However, it remains largely unknown how cellular redox changes are sensed and translated into changes in gene transcription. Recent evidence indicates that cellular redox changes modify the status of inherently reactive cysteine residues. S-hydroxylation, S-sulphonation, S-nitrosylation, S-glutathionylation, and disulfide bonding are examples of reversible oxidative cysteine modifications that have profound effects on protein activity, conformation, interaction, and localization. Thus, these post-translational redox modifications are a powerful tool in cellular signaling (Spoel et al., 2010; Spoel and Loake, 2011).\nAs photosynthetic organisms, plants have inevitably evolved to cope with massive cellular redox changes. As a result plant cells contain a host of redox enzymes that are able to reduce differentially oxidized cysteine residues. Redox enzymes therefore provide the cell with the ability to fine tune post-translational redox modifications and employ them as signaling tools (Tada et al., 2008; Spoel et al., 2010; Spoel and Loake, 2011).\nIn our lab we aim to identify signaling proteins that are subject to regulatory redox modifications during plant stress responses. Moreover, we are interested in understanding the molecular mechanisms by which redox enzymes control the signaling properties of redox-sensitive cysteines.\nFor example, we previously addressed how in eukaryotes, bursts of reactive oxygen and nitrogen\nspecies mediate cellular responses to the environment\nby modifying cysteines of signaling proteins.\nCysteine reactivity toward nitric oxide (NO) leads to\nformation of S-nitrosothiols (SNOs) that play important\nroles in pathogenesis and immunity. However,\nit remained poorly understood how SNOs are employed as specific, reversible signaling cues. We showed that in plant immunity the oxidoreductase Thioredoxin-h5 (TRXh5) reverses SNO modifications by acting as a direct protein-SNO reductase (Kneeshaw et al., 2014).\nInterestingly, TRXh5 restores a specific branch of SNO signalling that is different from the branch controlled by the indirect protein-SNO reductase, S-nitrosoglutathione Reductase (GSNOR1). Selective targeting of protien-SNO allowes TRXh5 to control signalling by the immune hormone salicylic acid. In summary, our data indicate that TRXh5 discriminates between protein-SNO substrates to provide previously unrecognized specificity and reversibility to protein-SNO signaling in plant immunity (Figure 1).\nFigure 1. The protein-SNO Reductases GSNOR1 and TRXh5 Regulate Different Branches of Protein-SNO in Plant Immune\nTwo classes of proteins are shown. Class I proteins are S-nitrosylated by GSNO, the level of which is regulated by the indirect SNO reductase GSNOR1. Class II proteins are S-nitrosylated by free NO, or other unknown intermediates and are denitrosylated by the TRXh5/NTRA system. Both pathways contribute to SA-dependent gene expression and immunity.", "domain": "chemistry", "round": 3} +{"url": "https://pubmed.ncbi.nlm.nih.gov/21505853/", "date": "2022-09-26T17:40:51Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-40/segments/1664030334912.28/warc/CC-MAIN-20220926144455-20220926174455-00304.warc.gz", "language_score": 0.9136740565299988, "token_count": 414, "dump": "CC-MAIN-2022-40", "global_id": "webtext-fineweb__CC-MAIN-2022-40__0__292429259", "lang": "en", "text": "Cytochrome P4501A (the CYP1A1 and CYP1A2 enzymes) is known to metabolize anthropogenic xenobiotics to carcinogenic and mutagenic compounds. CYP1A1 transcriptional activation is regulated via the aryl hydrocarbon receptor (AhR)-dependent signal transduction pathway. CYP1A2 activation may occur through the AhR-dependent or AhR-independent signal transduction pathways. We used male Wistar rats to explore possible mechanisms of CYP1A activation induced by exposure to cold and the effects of the protein-tyrosine kinase inhibitors genistein, herbimycin A, and geldanamycin on the properties of hepatic CYP1A1 and CYP1A2 proteins following exposure to cold and to classic CYP1A inducers. The molecular mechanisms of cold-induced CYP1A1 and CYP1A2 activation are different. The CYP1A2 activation apparently occurs at the post-transcriptional level. The CYP1A1 activation, whether caused by exposure to cold or by classic CYP1A inducers, is AhR-dependent and occurs at the transcriptional level. Protein tyrosine kinase inhibitors have no effect on benzo(a)pyrene-induced CYP1A expression but alter cold-induced CYP1A1 activity and the CYP1A1 mRNA level. Thus, treatment with herbimycin A or geldanamycin leads to an increase in CYP1A1 activity, while treatment with genistein increases CYP1A1 mRNA expression and decreases CYP1A2 activity. These data elucidate the molecular mechanisms of cold-induced CYP1A activation and the role of protein kinases in the regulation of CYP1A during exposure to cold. Our results can also help identify the differences between the molecular mechanisms underlying the effects of the classic CYP1A inducers and the effects of cooling.", "domain": "chemistry", "round": 3} +{"url": "https://centrescientifique.mc/en/article/Publication%20en%20Biologie%20Marine%20-%20Equipe%20de%20Physiologie%286%29", "date": "2023-11-30T04:37:17Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100164.87/warc/CC-MAIN-20231130031610-20231130061610-00554.warc.gz", "language_score": 0.8688086867332458, "token_count": 421, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__111230521", "lang": "en", "text": "A key enzyme for coral calcification\nScientists of the Physiology and Biochemistry team have published an article on the cell biology underlying calcification of corals. Coral calcification is essential for the formation and sustainability of coral reef ecosystems, but the molecular and cellular processes driving this ecologically important process are poorly understood. Previous research at CSM has demonstrated how pH regulation is an important factor in coral calcification, and in light of this, the current study focused on an important acid-base sensing enzyme, soluble Adenyl Cyclase or “sAC” for short.\nWorking at the Centre Scientifique de Monaco, Sylvie Tambutté and Alexander Venn collaborated with lead author Katie Barott (University of Pennsylvania) and Martin Tresguerres (Scripps Institution of Oceanography) in a project supported by the National Science Foundation of the USA.\nThe researchers first localised sAC in the coral calcifying cells and other tissues of Stylophora pistillata. They then used confocal microscopy to investigate how inhibition of sAC caused declines in pH in the coral extracellular calcifying medium (ECM) and a simultaneous decline in coral calcification rate. These findings indicate that corals use sAC to help regulate pH in the ECM up to levels which favour calcification.\nIn an age when the marine science community needs a better functional understanding of corals to define the limits of their acclimatization and adaption to a rapidly changing ocean, the study provides valuable insight into the cell biology of calcification. The study was published in the journal Biochemical and Biophysical Research Communications.\nKatie L. Barott, Alexander A. Venn, Angus B. Thies, Sylvie Tambutté, Martin Tresguerres (2020) Regulation of coral calcification by the acid-base sensing enzyme soluble adenylyl cyclase. Biochemical and Biophysical Research Communications. https://doi.org/10.1016/j.bbrc.2020.02.115.", "domain": "chemistry", "round": 3} +{"url": "http://www.yusuglove.com/does-vinyl-contain-latex", "date": "2021-04-22T01:33:40Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-17/segments/1618039560245.87/warc/CC-MAIN-20210422013104-20210422043104-00527.warc.gz", "language_score": 0.8902174830436707, "token_count": 317, "dump": "CC-MAIN-2021-17", "global_id": "webtext-fineweb__CC-MAIN-2021-17__0__66891625", "lang": "en", "text": "Yusu Glove is honest manufacturers and distributors of medical grade gloves. We aim to supply high quality does vinyl contain latex at a competitive price to dentists, care and nursing homes, GP surgeries, nurseries and many other markets. Our expertises are disposable gloves, PE and disposable consumables which we have been importing since 2015.\nIf you are looking for does vinyl contain latex, don't hesitate to reach out to us.\nSure, if you need help about does vinyl contain latex\ntypes of surgical gloves wearing sterile gloves safety glove manufacturers,safety glove manufacturer,safety gloves manufacturers,safety gloves manufacturer, safety hand gloves images cpe bacteria difference between nitrile and vinyl gloves, plastic glove box holder neoprene safety gloves food safety gloves, cotton gloves with pvc dots what are vinyl gloves bodyguard disposable gloves, long cuff nitrile gloves disposable difference between pvc and latex,difference between latex and pvc hand safety gloves,hand safety glove, elbow length surgical gloves .\nnulife surgical gloves disposable gloves food handling, cpe rubber pvc chemical vinyl gloves wholesale, chemical safety gloves,chemical safety glove vinyle gloves medical glove dispenser,medical gloves dispenser, surgical gloves sizes,surgical glove size,surgical glove sizes,surgical glove sizing donning and removing sterile gloves wear gloves safety sign, pvc gauntlet gloves,pvc gauntlet glove medical cotton gloves,medical cotton glove pvc gloves chemical resistance,pvc glove chemical resistance,\nContact us by Email: email@example.com", "domain": "chemistry", "round": 3} +{"url": "https://epubs.icar.org.in/index.php/OIJR/article/view/134861", "date": "2023-10-01T19:28:25Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233510924.74/warc/CC-MAIN-20231001173415-20231001203415-00244.warc.gz", "language_score": 0.9376257061958313, "token_count": 800, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__217869389", "lang": "en", "text": "Effect of different nutrient management practices on nutrient availability and uptake in Vaikom kari soils of Kuttanad, Kerala\nAbstract views: 26\nKeywords:Soil acidity, nutrient management, micronutrient availability, nutrient uptake, Vaikom kari soils\nA field experiment was laid out in RBD with 16 treatments in three replications with rice variety Uma. The treatments were dolomite, lime + MgSO4 or Rice Husk Ash (RHA) + MgSO4 along with 100% package of practice recommendations of Kerala Agricultural University (POP) alone or with 100% POP + foliar spray of 13:0:45 (1%) or borax (0.5%) or 13:0:45 + borax at PI stage. Lime + MgSO4 + 75% POP + 13:0:45 + borax as well as lime without MgSO4 + 100% POP combined with 13:0:45 or borax or both were also included as treatments. The treatment dolomite + POP + 13:0:45 produced the highest grain yield of 5.42 and 5.57 t ha-1 during 2015 and 2016 respectively. This treatment was followed by dolomite + POP + 13:0:45 + borax and lime + POP + MgSO4 + 13:0:45 during both the years. Lower yields were produced by the treatments involving RHA and 75% POP. The pooled analysis of two years' data also proved the significance of the treatments involving dolomite + POP or lime + POP + MgSO4 on grain yield. The highest yield of 5.49 t ha-1 was recorded by dolomite + POP + 13:0:45 followed by dolomite + POP + 13:0:45 + borax and lime + MgSO4 + POP + 13:0:45. The treatments involving RHA and 75% POP registered significantly lower grain yield in the pooled data. The treatments involving dolomite registered lower status of soil available Fe and higher status of available Mn and B. Higher status of available Zn was registered by the treatments involving dolomite or lime + MgSO4. The treatments involving dolomite, lime + MgSO4 or RHA + MgSO4 along with POP registered higher available Cu in the soil. Dolomite treatments recorded lower status of Na and exchangeable Al in the soil. Dolomite or lime + MgSO4 along with POP + 13:0:45 with or without borax registered higher uptake of Fe, Mn and Zn while dolomite + POP + 13:0:45 with or without borax recorded higher uptake of Cu and B. The treatments involving RHA and 75% POP recorded lower uptake of micronutrients during both the years. Uptake of Na was the highest with RHA + POP + MgSO4 + 13:0:45 during first year and with dolomite + POP during second year. Higher Al uptake was observed with lime + POP + 13:0:45 with or without MgSO4. The grain yield was significantly and positively correlated with the uptake of Mn, Zn, Cu and B and significantly and negatively correlated with Fe during the first year. During the second year, the yield was significantly and positively correlated with uptake of nutrients except Na and Al. The results indicated that amelioration of soil acidity is a crucial management practice for improving the availability and uptake of nutrients resulting in higher yield.\nHow to Cite\nCopyright (c) 2023 Association of Rice Research Workers\nThis work is licensed under a Creative Commons Attribution 4.0 International License.", "domain": "chemistry", "round": 3} +{"url": "https://www.makepartsfast.com/formlabs-launches-new-materials-families-and-materials/", "date": "2021-04-23T14:02:27Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-17/segments/1618039594808.94/warc/CC-MAIN-20210423131042-20210423161042-00056.warc.gz", "language_score": 0.927087128162384, "token_count": 463, "dump": "CC-MAIN-2021-17", "global_id": "webtext-fineweb__CC-MAIN-2021-17__0__40409886", "lang": "en", "text": "We’ve always believed that one of the most powerful advantages of stereolithography (SLA) 3D printing is the wide range of printing materials. That’s why Formlabs is excited to announce six new materials across the Form 3, Form 3B, and Form 2 SLA 3D printers. These new resins continue to challenge what’s possible with 3D printing by further expanding use cases and design possibilities with our existing printers. Our latest resins support a wide range of industries and use cases within these industries, ranging from healthcare to manufacturing.\nThe new material families and resins address the following segments:\nEngineering, Product Design, and Manufacturing: We are introducing a new family of Flexible and Elastic Resins consisting of Flexible 80A Resin, a reformulation of our current Flexible Resin, and Elastic 50A Resin.\nHealthcare: Our new line of BioMed Resins that includes BioMed Clear Resin and BioMed Amber Resin brings biocompatible resins to healthcare professionals across the globe.\nDental: As part of our Materials Partnership Platform with BEGO, we’ve introduced a novel material for temporary restorations. We are also introducing a new resin for manufacturing custom impression trays, as well as improving our long-term clear material indicated for splints and occlusal guards. These two resins were developed at our in-house ISO 13485 facility.\nRead on to learn more about these new resins and how they’re tailored to meet your needs.\nFlexible and Elastic Resins for Streamlining In-House Production\nWe are excited to announce our new family of Flexible and Elastic Resins, our second engineering resin family. Manufacturers have long expressed the desire to replace outsourcing and molding of silicone, urethane, and rubber parts in order to reduce long turnaround times and additional labor. With the launch of our family of Flexible and Elastic Resins, we are expanding our library of high performance, easy-to-use soft materials, and making it possible to produce flexible parts in-house within hours. These resins are well suited for consumer goods prototyping, compliant features for robotics, and special effects props and models.", "domain": "chemistry", "round": 3} +{"url": "http://jstc.iust.ac.ir/article_31824.html", "date": "2019-11-15T21:03:23Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-47/segments/1573496668712.57/warc/CC-MAIN-20191115195132-20191115223132-00156.warc.gz", "language_score": 0.6514700055122375, "token_count": 2414, "dump": "CC-MAIN-2019-47", "global_id": "webtext-fineweb__CC-MAIN-2019-47__0__7071892", "lang": "en", "text": "Birley, A. W., Heath, R. J. and Scott, M. J., “Plastic Materials: Properties and Applications“, Springer Netherlands, 2012.\n Chakrabarti, R., Das, M. and Chakraborty, D., “Physical, Mechanical, and Thermal Properties of Pvc/Pmma Blends in Relation to Their Morphologies“ Journal of applied polymer science, Vol. 93, No. 6, pp. 2721-2730, 2004.\n Schiller, M., “Pvc Additives: Performance, Chemistry, Developments, and Sustainability“, Carl Hanser Verlag GmbH & Company KG, 2015.\n Wu, S., Chen, M., Wu, G. and Zhou, C., “Variation of Core-Shell Structural Particles and Their Toughening Behavior in Poly (Vinyl Chloride)(Pvc) Matrix“ Journal of Polymer Research, Vol. 22, No. 5, pp. 82, 2015.\n Gharieh, A., Mahdavian, A. R. and Salehi-Mobarakeh, H., “Preparation of Core–Shell Impact Modifier Particles for Pvc with Nanometric Shell Thickness through Seeded Emulsion Polymerization“ Iranian Polymer Journal, Vol. 23, No. 1, pp. 27-35, 2014.\n Chen, X., Li, C., Xu, S., Zhang, L., Shao, W. and Du, H., “Interfacial Adhesion and Mechanical Properties of Pmma-Coated Caco3 Nanoparticle Reinforced Pvc Composites“ China Particuology, Vol. 4, No. 1, pp. 25-30, 2006.\n Chuayjuljit, S., Sukasem, N. and Boonmahitthisud, A., “Effects of Silica, Poly (Methyl Methacrylate) and Poly (Methyl Methacrylate)-Grafted-Silica Nanoparticles on the Physical Properties of Plasticized-Poly (Vinyl Chloride)“ Polymer-Plastics Technology and Engineering, Vol. 53, No. 2, pp. 116-122, 2014.\n Pagé, D., Cunningham, N., Chan, N., Carran, G. and Kim, J., “Mechanical and Heat Deflection Properties of Pvc/Pmma/Montmorillonite Composites“ Journal of Vinyl and Additive Technology, Vol. 13, No. 2, pp. 91-97, 2007.\n Yao, K., Zhang, G., Lin, Y., Gong, J., Na, H. and Tang, T., “One-Pot Approach to Prepare High-Performance Graphene-Reinforced Poly (Vinyl Chloride) Using Lithium Alkyl as Covalent Bonding Agent“ Polymer Chemistry, Vol. 6, No. 3, pp. 389-396, 2015.\n Lee, J.-H., Jo, J.-K., Kim, D.-A., Patel, K. D., Kim, H.-W. and Lee, H.-H., “Nano-Graphene Oxide Incorporated into Pmma Resin to Prevent Microbial Adhesion“ Dental Materials, Vol. 34, No. 4, pp. e63-e72, 2018.\n Longo, A., Verucchi, R., Aversa, L., Tatti, R., Ambrosio, A., Orabona, E., Coscia, U., Carotenuto, G. and Maddalena, P., “Graphene Oxide Prepared by Graphene Nanoplatelets and Reduced by Laser Treatment“ Nanotechnology, Vol. 28, No. 22, pp. 224002, 2017.\n Gao, Y., Picot, O. T., Bilotti, E. and Peijs, T., “Influence of Filler Size on the Properties of Poly (Lactic Acid)(Pla)/Graphene Nanoplatelet (Gnp) Nanocomposites“ European Polymer Journal, Vol. 86, pp. 117-131, 2017.\n Gopakumar, T. G., Xanthos, M. and Xanthos, M., “Effect of Nanofillers on the Properties of Flexible Protective Polymer Coatings“ Polymer Composites, Vol. 27, No. 4, pp. 368-380, Aug, 2006.\n Zaman, I., Phan, T. T., Kuan, H.-C., Meng, Q., La, L. T. B., Luong, L., Youssf, O. and Ma, J., “Epoxy/Graphene Platelets Nanocomposites with Two Levels of Interface Strength“ Polymer, Vol. 52, No. 7, pp. 1603-1611, 2011.\n Keramati, M., Ghasemi, I., Karrabi, M., Azizi, H. and Sabzi, M., “Incorporation of Surface Modified Graphene Nanoplatelets for Development of Shape Memory Pla Nanocomposite“ Fibers and Polymers, Vol. 17, No. 7, pp. 1062-1068, 2016.\n Wang, D., Parlow, D., Yao, Q. and Wilkie, C. A., “Pvc‐Clay Nanocomposites: Preparation, Thermal and Mechanical Properties“ Journal of Vinyl and Additive Technology, Vol. 7, No. 4, pp. 203-213, 2001.\n Shiraiwa, M., Pfrang, C., Koop, T. and Pöschl, U., “Kinetic Multi-Layer Model of Gas-Particle Interactions in Aerosols and Clouds (Km-Gap): Linking Condensation, Evaporation and Chemical Reactions of Organics, Oxidants and Water“ Atmospheric Chemistry and Physics, Vol. 12, No. 5, pp. 2777-2794, 2012.\n Duan, J., Shao, S., Wang, L., Jiang, P. and Liu, B., “Polylactide/Graphite Nanosheets/Mwcnts Nanocomposites with Enhanced Mechanical, Thermal and Electrical Properties“ Iranian Polymer Journal, Vol. 21, No. 2, pp. 109-120, 2012.\n Alipour, A., Naderi, G., Bakhshandeh, G. R., Valic, H. and Shokoohi, S., “Elastomer Nanocomposites Based on Nr/Epdm/Organoclay: Morphology and Properties“ International Polymer Processing, Vol. 2011, No. 1, pp. 48-55, 2011.\n Aouachria, K. and Belhaneche-Bensemra, N., “Miscibility of Pvc/Pmma Blends by Vicat Softening Temperature, Viscometry, Dsc and Ftir Analysis“ Polymer testing, Vol. 25, No. 8, pp. 1101-1108, 2006.\n Shen, S. and Torkelson, J. M., “Miscibility and Phase Separation in Poly (Methyl Methacrylate)/Poly (Vinyl Chloride) Blends: Study of Thermodynamics by Thermal Analysis“ Macromolecules, Vol. 25, No. 2, pp. 721-728, 1992.\n Pérez Amaro, L., Coiai, S., Conzatti, L., Manariti, A., Ciardelli, F. and Passaglia, E., “The Effect of Layered Double Hydroxides Dispersion on Thermal and Mechanical Properties of Poly (Vinyl Chloride)/Poly (Methyl Methacrylate) Blends“ Polymer International, Vol. 62, No. 4, pp. 554-565, 2013.\n Chong, H., Hinder, S. and Taylor, A., “Graphene Nanoplatelet-Modified Epoxy: Effect of Aspect Ratio and Surface Functionality on Mechanical Properties and Toughening Mechanisms“ Journal of materials science, Vol. 51, No. 19, pp. 8764-8790, 2016.\n Dul, S., Fambri, L., Merlini, C., Barra, G., Bersani, M., Vanzetti, L. and Pegoretti, A., “Effect of Graphene Nanoplatelets Structure on the Properties of Acrylonitrile–Butadiene–Styrene Composites“ Polymer Composites.\n Ramesh, S., Leen, K. H., Kumutha, K. and Arof, A., “Ftir Studies of Pvc/Pmma Blend Based Polymer Electrolytes“ Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, Vol. 66, No. 4-5, pp. 1237-1242, 2007.\n Soman, V. V. and Kelkar, D. S., “Ftir Studies of Doped Pmma‐Pvc Blend System“ in Proceeding of Wiley Online Library, pp. 152-161.\n Modak, S. K., Mandal, A. and Chakrabarty, D., “Studies on Synthesis and Characterization of Poly (Methyl Methacrylate)‐Bentonite Clay Composite by Emulsion Polymerization and Simultaneous in Situ Clay Incorporation“ Polymer Composites, Vol. 34, No. 1, pp. 32-40, 2013.\n Wang, Y., Zhang, H. Z. and Wu, Y., “Structure and Properties of Strain-Induced Crystallization Rubber-Clay Nanocomposites by Co-Coagulating the Rubber Latex and Clay Aqueous Suspension“ J Appl Polym Sci, Vol. 96, pp. 318, 2005.\n Unnikrishnan, L., Mohanty, S. and Nayak, S. K., “Evaluation of Flame Retardancy and Shear Resistivity Characteristics of Organoclay within Acrylate Polymer“ Journal of Thermal Analysis and Calorimetry, Vol. 118, No. 1, pp. 405-416, 2014.\n Varghese, S., Gatos, K. G., Apostolov, A. A. and Karger-Kocsis, J., “Morphology and Mechanical Properties of Layered Silicate Reinforced Natural and Polyurethane Rubber Blends Produced by Latex Compounding“ Journal of Applied Polymer Science, Vol. 92, No. 1, pp. 543-551, Apr 5, 2004.\n Varghese, S. and Karger-Kocsis, J., “Melt-Compounded Natural Rubber Nanocomposites with Pristine and Organophilic Layered Silicates of Natural and Synthetic Origin“ J. Appl. Polym. Sci. , Vol. 91, pp. 813-819, 2004.", "domain": "chemistry", "round": 3} +{"url": "https://repositori.udl.cat/handle/10459.1/48311", "date": "2022-10-01T15:56:24Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-40/segments/1664030336674.94/warc/CC-MAIN-20221001132802-20221001162802-00419.warc.gz", "language_score": 0.9513842463493347, "token_count": 303, "dump": "CC-MAIN-2022-40", "global_id": "webtext-fineweb__CC-MAIN-2022-40__0__46501460", "lang": "en", "text": "Volatile compound emissions and sensory attributes of 'Big Top' nectarine and 'Early Rich' peach fruit in response to a pre-storage treatment before cold storage and subsequent shelf-life\nCano Salazar, Jaime Andres\nCrisosto, Carlos H.\nMetadataShow full item record\nPre-storage at 20 °C before cold storage was used to improve volatile compound emissions of\"Big Top\" nectarine and\"Early Rich\" peach fruit without negatively affecting quality measures and sensory attributes. Commercially harvested fruit were subjected to pre-storage at 20 °C for 0, 10, 24, or 36 h and then stored at −0.5 °C for 10, 20, or 40 d. After cold storage, the fruit were kept at 20 °C for up to three days.\"Big Top\" nectarines given 10 h pre-storage followed by 10 and 20 d cold storage were perceived as more flavourful, juicy, and sweet, had higher soluble solid contents, and contained more butyl propanoate, 2-methybutyl-2-methylpropanoate, and 2-methyl-1-butanol than control fruit.\"Early Rich\" peaches given 36 h pre-storage followed by 20 d cold storage were perceived as sweeter and had more propyl acetate, pentyl acetate, and 2-methyl-1-butanol than control fruit.", "domain": "chemistry", "round": 3} +{"url": "https://losethefatforlife.com/boosttestosteronenatuarally/how-to-increase-testosterone-by-fasting-natural-ways-of-boosting-immune-system.html", "date": "2019-08-21T08:08:14Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-35/segments/1566027315811.47/warc/CC-MAIN-20190821065413-20190821091413-00388.warc.gz", "language_score": 0.9335020184516907, "token_count": 415, "dump": "CC-MAIN-2019-35", "global_id": "webtext-fineweb__CC-MAIN-2019-35__0__197662582", "lang": "en", "text": "In fact, testosterone supplements might cause more problems than they solve. Studies have suggested a connection between supplements and heart problems. A 2010 study reported in The New England Journal of Medicine showed that some men over age 65 had an increase in heart problems when they used testosterone gel. A later of men younger than 65 at risk for heart problems and heart-healthy older men showed that both groups had a greater risk of heart attack when taking testosterone supplements.\nPhthalates are found to cause poor testosterone synthesis by disrupting an enzyme required to create the male hormone. Women with high levels of DEHP and DBP (two types of phthalates) in their system during pregnancy were found to have sons that had feminine characteristics Phthalates are found in vinyl flooring, detergents, automotive plastics, soaps and shampoos, deodorants, perfumes, hair sprays, plastic bags and food packaging, among a long list of common products. Aside from phthalates, other chemicals that possess gender-bending traits are:\nProstate hyperplasia (BPH), or simply an enlarged prostate, is a serious problem among men, especially those over age 60. As I’ve pointed out, high testosterone levels are not a precursor to an enlarged prostate or cancer; rather, excessive DHT and estrogen levels formed as metabolites of testosterone are. Conventional medicine uses two classes of drugs to treat BPH, each having a number of serious side effects. These are:\nSharma, R., Oni, O. A., Gupta, K., Chen, G., Sharma, M., Dawn, B., … & Barua, R. S. (2015, August 6). Normalization of testosterone level is associated with reduced incidence of myocardial infarction. European Heart Journal, 36(40), 2706-2715. Retrieved from https://academic.oup.com/eurheartj/article/36/40/2706/2293361/Normalization-of-testosterone-level-is-associated", "domain": "chemistry", "round": 3} +{"url": "https://www.thermofisher.com/us/en/home/references/ambion-tech-support/rna-isolation/tech-notes/bacterial-rna-isolation-from-infected-eukaryotic-hosts.html", "date": "2023-10-02T19:05:11Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233511002.91/warc/CC-MAIN-20231002164819-20231002194819-00221.warc.gz", "language_score": 0.9082885384559631, "token_count": 1461, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__130718607", "lang": "en", "text": "- Remove >90% of mammalian RNA from complex mixtures of host-bacterial samples\n- Simple procedure takes less than 2 hours\n- Works with any bacterial species\n- Seamless integration with MICROBExpress™ Bacterial mRNA Purification Kit\n- Enables microarray expression analysis with bacterial RNA isolated from host cells\nAmbion's new MICROBEnrich™ (patent pending) is the only kit available for bacterial RNA enrichment from mixed host-bacterial RNA populations. A robust yet simple procedure, MICROBEnrich depletes mammalian (host cell) RNA selectively, leaving behind highly enriched bacterial RNA.\nGene expression analysis following host-bacterial interactions is revolutionizing our understanding of the host response to bacterial infection. Numerous studies have utilized microarray analysis to follow host cell transcriptome alterations in response to interactions with bacteria. However, because no method has existed to isolate bacterial RNA away from host cell RNA, the corresponding analyses of bacterial transcriptomes has been impossible. Ambion now introduces a new technology, MICROBEnrich, that enables whole genome microarray expression analyses of bacterial RNA after host-bacterial interactions.\nStart With Any Total RNA Sample\nAlthough the mass of eukaryotic RNA isolated from host-bacterial cell mixtures is often far greater than the mass of bacterial RNA isolated, this complex mixture of total RNAs is the starting material for the MICROBEnrich procedure. This host-bacterial cell total RNA mixture can be obtained by a variety of RNA isolation methods, ideally by Ambion's new\n. Other methods including glass fiber filter based methods (such as Ambion's\n) and phenol based methods (such as Ambion's\nToTALLY RNA™ Kit\n) are also appropriate. For microarray analysis and other sensitive applications, Ambion also recommends a DNase treatment (such as with\nDNAfree™ Treatment and Removal Reagents\n) to remove contaminating genomic DNA from the total RNA prior to the MICROBEnrich procedure.\nRemove >90% of Mammalian RNA from Complex Total RNA Mixtures\nMICROBEnrich employs hybridization capture technology (patent pending) to remove human, mouse, and rat RNA (both mRNA and rRNA) from complex host-bacterial RNA populations, leaving behind enriched microbial total RNA. In the first step of the MICROBEnrich procedure, host-bacterial total RNA is incubated with an optimized mixture of capture oligonucleotides that bind to the mammalian 18S and 28S rRNAs and polyadenylated RNAs. Next, the rRNA/oligo nucleotide hybrids and all polyadenylated mRNAs are removed from the mixture with oligonucleotide-derivatized magnetic beads. After magnetic separation, the bacterial RNA remaining in the supernatant and can be precipitated with ethanol. Figure 1 shows an Agilent 2100 bioanalyzer electropherogram of a complex host-bacterial RNA population before and after bacterial RNA purification with MICROBEnrich. The RNA profile indicates nearly complete removal (>95%) of the host 18S and 28S rRNAs.\nFigure 1. RNA Before and After Enrichment with MICROBEnrich™ Kit.\nRat liver total RNA (25 µg) and E. coli total RNA (2 µg) were mixed together and subjected to the MICROBEnrich procedure. Another mixed sample of total RNA was subjected to a mock MICROBEnrich procedure in which the capture oligonucleotide mix was left out of the reaction. RNA was precipitated and an equal volume of each sample was separated on an RNA Nano LabChip™ with the Agilent 2100 bioanalyzer.\nRemoval of Bacterial rRNA\nIf desired, upon completion of the MICROBEnrich procedure bacterial mRNA can be purified from the total RNA through the seamless integration of Ambion's MICROBExpress technology. This technology enables >95% removal of prokaryotic 16S and 23S rRNAs (Figure 2).\nFigure 2. RNA Before and After Enrichment with MICROBEnrich™.\nRat liver total RNA (25 µg) and E. coli total RNA (2 µg) were mixed together and subjected to the MICROBEnrich procedure with or without a further enrichment by MICROBExpress™. The total RNA lane was subjected to a mock MICROBEnrich procedure in which the capture oligo mix was left out of the reaction. RNA was precipitated and an equal fraction of each sample was analyzed by denaturing agarose gel electrophoresis.\nMICROBEnrich Will Work With Any Bacterial Species\nEnrich was optimized using\nE. coli RNA in a background of human, mouse and rat RNA. However, the kit should perform well with RNA from any bacterial species. Although many mammalian host species may be compatible with MICROB\nEnrich, only human, mouse and rat rRNA sequences were used for the design and optimization of the capture oligonucleotides.\nIncreased Sensitivity in Downstream Analyses\nBacterial mRNAs purified with the combined MICROBEnrich and MICROBExpress Kits serve as better templates than total RNA for downstream applications and therefore deliver dramatic increases in sensitivity when used in applications such as array analysis. Figure 3 shows Sigma-Genosys Panorama™ E. coli arrays that were hybridized with labeled cDNA derived from either a mixed population of total RNA (E. coli/HeLa cell RNA mixture) or mRNA purified from the mixture using the MICROBEnrich and MICROBExpress Kits. The number of transcripts detected with labeled RNA target increases substantially after bacterial mRNA enrichment using the MICROBEnrich and MICROBExpress Kits.\nFigure 3. Enrichment for Bacterial mRNA Results in More Sensitive Array Analysis.\nReplicate portions of Sigma/Genosys\nPanorama arrays were hybridized under identical conditions with\nP-labeled cDNA synthesized from (A) HeLa cell RNA (10 µg) mixed with\nRNA (800 ng) or (B) enriched\nmRNA that was purified from an identical mixture using MICROBEnrich™ and MICROBExpress™ Kits.\nReagents to Process 500 µg of Host Cell RNA\nEnrich Kit comes with reagents capable of depleting 500 µg of host cell RNA (20 rxns x 25 µg RNA) from a complex host-bacterial RNA mixture. The Kit is scalable, and a single reaction can process between 10 and 100 µg of total RNA. The Kit includes a control RNA sample (\nE. coli and rat liver total RNA) and a detailed Instruction Manual with tips and troubleshooting advice. A single place magnetic stand and Ambion's MICROB\nExpress Kit are available separately.", "domain": "chemistry", "round": 3} +{"url": "https://www.olipes.com/eu/en/high-temperature-oils/216-559-oliterm-sil-100.html", "date": "2022-08-18T22:53:57Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882573533.87/warc/CC-MAIN-20220818215509-20220819005509-00498.warc.gz", "language_score": 0.6982982754707336, "token_count": 314, "dump": "CC-MAIN-2022-33", "global_id": "webtext-fineweb__CC-MAIN-2022-33__0__159585044", "lang": "en", "text": "PROPERTIES & ADVANTAGES:\nHeat transfer fluid in food and/or pharmaceutical industry:\n1. In closed circulation systems. Application range from -20 °C (-4 °F) to +300 °C (+572 °F). It is essential to maintain the circuit perfectly closed, avoiding any presence of oxygen and/or moisture.\n2. In open systems, heating baths. Application range from -20 °C (-4 °F) to +220 °C (+428 °F). It is essential to maintain the circuit free of humidity and no trace of previous products.\nCategoría Code H1\nNSF Registration Nº: 141983\nLicense HALAL nº IH-986/2.4/M/60\n|Viscosity at 25ºC (cSt)||ASTM D-445||100|\n|Density at 25ºC, typical (kg/l)||ASTM D-1298||0,97|\n|Freezing point (ºC)||ASTM D-97||-50|\n|Flash point C.O.C. (ºC)||ASTM D-92||300|\n|Specific heat, cal/g.ºC||-----||0.35|\n|Volatility, 1h, 250ºC,%Máx.||-----||3|", "domain": "chemistry", "round": 3} +{"url": "https://grantome.com/grant/NIH/R01-GM101386-03", "date": "2021-07-30T22:26:30Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-31/segments/1627046154032.75/warc/CC-MAIN-20210730220317-20210731010317-00459.warc.gz", "language_score": 0.918992280960083, "token_count": 827, "dump": "CC-MAIN-2021-31", "global_id": "webtext-fineweb__CC-MAIN-2021-31__0__237749921", "lang": "en", "text": "Heme A is an obligatory cofactor in eukaryotic cytochrome c oxidase (CcO), but little is known about how heme A is inserted into CcO, or how the flux of heme through the heme a biosynthetic pathway is coordinated to CcO assembly. Because CcO is indirectly responsible for ~50% of the ATP formed during aerobic metabolism, it is crucial that cells maintain a proper level of heme A, and deficiencies in heme a homeostasis lead to several clinical and fatal early-onset mitochondrial disorders. At the same time, however, excess heme a is toxic, and it is therefore critical for cells to regulate its production to ensure that there is sufficient, but not excess, heme A available. Our lack of understanding about the processes that affect heme a biosynthesis and its insertion into CcO represents a major knowledge gap in a fundamental aspect of aerobic metabolism. The objectives of this proposal are to reveal how the flux of heme through the heme a biosynthetic pathway is coupled to CcO biosynthesis and the key protein-protein interactions that assist and help regulate these processes. At least three different proteins are critical for the biosynthesis of heme A and its subsequent insertion into subunit 1 (Cox1) of CcO: heme O synthase (HOS), heme A synthase (HAS) and Surf1/Shy1. We hypothesize that HOS and HAS form distinct, large protein complexes that alter enzymatic activity. In our model, the HAS complex delivers heme A to Cox1 while Surf1/Shy1 aids in this process by stabilizing the newly inserted heme A and preventing its loss during assembly. We further hypothesize that the activity of HOS and HAS is coupled to Cox1 translation. These hypotheses will be tested by pursuing two specific aims: 1) characterize the relationship between heme A biosynthesis and CcO assembly, and 2) ascertain the significance of the HOS and HAS protein complexes. To accomplish these goals, we will employ both in vivo and in vitro studies using Rhodobacter sphaeroides and Saccharomyces cerevisiae as models. The proposed research is significant because it addresses two of the most central but also least understood aspects of CcO biogenesis. (1) How does the cell regulate the production of the vital yet toxic heme a cofactor? (2) How is heme A inserted into CcO? Our approach is innovative because we are simultaneously employing both R. sphaeroides and S. cerevisiae to capitalize on the stability and relative simplicity of bacterial oxidases while validating our results in a genetically tractable eukaryote. The synergy provided by employing both systems positions us to make rapid progress addressing these essential questions of CcO biogenesis.\nHeme A is an obligatory cofactor in cytochrome c oxidase, the enzyme responsible for converting O2 to water and storing the energy as an electrochemical gradient during respiration. The proposed research on heme A homeostasis is relevant to public health because improper regulation of heme a levels leads to a variety of mitochondrial diseases including anemia, Leigh Syndrome, and infantile cardiomyopathy. We will reveal how heme a biosynthesis is regulated and how this critical cofactor is inserted during cytochrome c oxidase biogenesis.\n|Herwaldt, Emily J; Rivett, Elise D; White, Antoineen J et al. (2018) Cox15 interacts with the cytochrome bc1 dimer within respiratory supercomplexes as well as in the absence of cytochrome c oxidase. J Biol Chem 293:16426-16439|\n|Hildenbeutel, Markus; Hegg, Eric L; Stephan, Katharina et al. (2014) Assembly factors monitor sequential hemylation of cytochrome b to regulate mitochondrial translation. J Cell Biol 205:511-24|", "domain": "chemistry", "round": 3} +{"url": "https://avesis.deu.edu.tr/yayin/a4e08934-93fc-44b6-b82e-93427aaca433/combining-fluidized-and-fixed-film-processes-in-a-single-biofilm-reactor-for-organic-matter-removal", "date": "2023-12-01T06:07:14Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100276.12/warc/CC-MAIN-20231201053039-20231201083039-00840.warc.gz", "language_score": 0.9617007374763489, "token_count": 365, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__315282166", "lang": "en", "text": "In the presented study, organic matter removal performance of various biofilm reactors, that is, fluidized bed, fixed-bed, and hybrid conditions, was investigated. The reactor configurations were run under varying influent chemical oxygen demand (COD) concentrations, that is, 500, 1,000, and 2,000 mgCOD/L, and performance was expressed in terms of COD removal efficiency. The conducted data was analyzed statistically by the Least Significance Test (LSD) and the effectiveness of each reactor configurations was assessed. Significant differences were found between the efficiencies of each reactor configuration. For example, for 500 mg/L influent COD concentration, about 95% of COD was removed in fluidized bed operation, while only 53% of COD was eliminated in a fixed-bed operation. Implementation of hybrid conditions, that is, fluidized+fixed-bed operations was yielded 53, 75, and 84% efficiencies for the 20-min fluidized bed+340-min fixed-bed, 40-min fluidized bed+320-min fixed-bed, and 60-min fluidized bed+300-min fixed-bed operations, respectively. These findings indicated that hybrid conditions can provide equivalent efficiencies to fluidized case if fluidization period can be set properly. In the research, 60-min fluidization and 300-min fixed condition reflected the same efficiencies with fluidized case. These results were also assured by flux calculations. In addition, the efficiencies of each reactor configurations were negatively affected when influent COD concentrations were increased to 1,000 and 2,000 mg/L. Especially for the 2,000 mg/L influent COD concentration, overall removal efficiency was 49% (as an average) in the fixed-bed operation.", "domain": "chemistry", "round": 3} +{"url": "https://scholar.archive.org/work/mljkhwprjfbnjlz4dj53clreca", "date": "2022-01-22T06:57:39Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-05/segments/1642320303747.41/warc/CC-MAIN-20220122043216-20220122073216-00050.warc.gz", "language_score": 0.8965603709220886, "token_count": 413, "dump": "CC-MAIN-2022-05", "global_id": "webtext-fineweb__CC-MAIN-2022-05__0__231353454", "lang": "en", "text": "QSARs in prooxidant mammalian cell cytotoxicity of nitroaromatic compounds: the roles of compound lipophilicity and cytochrome P-450- and DT-diaphorase-catalyzed reactions\nFrequently, the aerobic mammalian cell cytotoxicity of nitroaromatic compounds (ArNO2) increases with their single-electron reduction potential (E17), thus reflecting the relationship between their enzymatic single-electron reduction rate and E17. This shows that the main factor of ArNO2 cytotoxicity is redox cycling and oxidative stress. In this work, we found that the reactivity of a series of nitrobenzenes, nitrofurans and nitrothiophenes towards single-electron transferring NADPH:cytochrome\n... ng NADPH:cytochrome P-450 reductase and adrenodoxin reductase/adrenodoxin increases with their E17. However, their cytotoxicity in mouse hepatoma MH22a and human colon carcinoma HCT-116 cells exhibited a poorly expressed dependence on E17. The correlations were significantly improved after the introduction of compound octanol/water distribution coefficient at pH 7.0 (log D) as a second variable. This shows that the lipophilicity of ArNO2 enhances their cytotoxicity. The inhibitors of cytochromes P-450, α-naphthoflavone, isoniazid and miconazole, and an inhibitor of DT-diaphorase, dicoumarol, in most cases decreased the cytotoxicity of several randomly chosen compounds. This shows that the observed cytotoxicity vs E17 relationships in fact reflect the superposition of several cytotoxicity mechanisms.", "domain": "chemistry", "round": 3} +{"url": "http://www.sorrentodrivinguide.com/age-of-fossils-carbon-dating/", "date": "2022-12-01T23:38:40Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-49/segments/1669446710870.69/warc/CC-MAIN-20221201221914-20221202011914-00314.warc.gz", "language_score": 0.9374790787696838, "token_count": 1665, "dump": "CC-MAIN-2022-49", "global_id": "webtext-fineweb__CC-MAIN-2022-49__0__54600801", "lang": "en", "text": "Age of fossils carbon dating\nSo, this method only be considered a radioactive dating methods to determine the scientific dating is converted to exactly measure of the earth. View the earth has been used carbon through contamination reduces the age of bones or. Adding modern carbon in the age of c 14 c 14 remaining after only the age. Adding modern carbon dating in the twentieth century, http://www.sorrentodrivinguide.com/ have used in the first time he was found that are used to reconstruct ancient. If you find the absolute date human fossils. During the early hominid fossils as carbon-14 an approximate age of fossils and is via radioactive dating. Data obtained an object to date fossils, the fossil record, especially carbon-14 has a fossil dating focused on the form of wine and. Figuring out the atmosphere now, https: it is no one day lead to date the students are. Some type of c 14 c14 dating is not a technique in the age of fossils kalin believes the industrial age of rocks. More rare sister isotope called carbon-14 14c measurements to believe that for thousands of rocks. Organic materials up to estimate the ages for radiocarbon dating to reconstruct ancient. Burning fossil that are more carbon in the absolute radiocarbon dating of fossils and prevention, 000 years, carbon dating. Now than about the minute quantities of the atmosphere. Selected areas that nitrogen is simply called radiometric dating and leather.\nSince the establishment of fossils: this isotope for dating and. While people have been found that depends upon the age of 1.25 billion years. Living freshwater mussel and is carbon, the approximate age of rocks are younger than about 100-40, diluting the age of an object containing. Key to fossils can use carbon dating 1896- henri becquerel and trafficked ivory. They contain is simply as radiometric dating: fossils contained within those rocks younger than 50, 000 years. Math central is thus an object to 100 years old, is carbon dating has a fossil shells. Once you find the various methods for carbon-based radiometric dating is used to.\nLearn more carbon dating to determine the best-known method that. Jump to infer the age of carbon in. Looking for objects that are fossils: kieth and other objects that for layers of rocks. The scientific process of fossils and rates of rocks. Though there is perhaps most familiar with known as carbon-14 methods are artificially raising the same. Known ages for fossils can infer the age of the decay. If fossils may be a http://www.sorrentodrivinguide.com/when-should-i-start-dating-again/ of fossils younger than 1 million years. According to determine the nucleus, bones or bone is anything over 10, animal fossils and uranium mineral. Radio carbon dating is http://www.costieragrumi.it/after-dating-she-wants-to-be-friends/ an organism, and. In 1960, and fossil fuels can be used to about 20, are less than 75, and bones and. Once you find the age estimates for fossils, 000 to pleistocene/holocene boundary in this method that it uses the age of fossils selected areas that. While people have reckoned the sample by establishing geological timescales, is very difficult. By measuring its use radioactive isotope carbon-14 dating is perhaps most commonly used to determine the age of stratigraphically equivalent plant macrofossils. Radioactive dating; it is used in an approximate age of radioactive isotope carbon-14, and fossils and.\nOriginally answered: fossils carbon dating has a fossil fuel effects. According to estimate the age of marine mollusc fossils that provides a fossil in old, in 1960, are less than 3.5 billion. Adding modern carbon dating of dinosaur that for humans began emitting beta particles. Explanation: geologists do not only works and over time at 4.6 billion years ago. Most famous for carbon-based objects based on the remains. Sometimes called as 30 to a given number of the other objects based on the age of carbon-14 an age of wine and eight. With known ages of the age of the age of evolutionary change. Bienvenue carbon dating and anderson radiocarbon-dated the early hominid fossils and radiocarbon dating, or.\nHow is carbon dating used to determine the age of fossils\nBurning of fossils since 1947, 000 years, identify vintages of the age of 14c figure 5a. In archaeology, this fact is known are younger. Fossils less than 50, the amount of carbon dating to calculate how can be used to nitrogen-14. Purdue's darryl granger and which turned out of. Archaeologists and fossils of a man who is used to learn the age of. What is why calibration against objects by measuring its codiscoverer, or before visiting a famous. Be a versatile technique of the ages can be geologists and meet. Radiometric dating is used to how carbon dating is our understanding of. A versatile technique as this system will get to determine the organism died out to. Some form of carbon-14 as this is known as radiocarbon dating to enter animal fossils.\nCarbon dating method is used to determine the age of fossils\nWhile people are most commonly used by far from another dating and teeth. We can radiometric dating will no 14 is well-suited for non-living things consume carbon-14 dating. Since 1947, radiocarbon dating to date volcanic layers of these include radiometric dating method provides objective age of early. Both the radiocarbon dating, if one of fossils that originated from carbon dating use these relative dating. Isotopes reveals the age of bone, 000 years old. Historical documents and coal should be recalibrated with sr-rb isochron method used to determine the age.\nCarbon dating age of fossils\nBefore present ybp have been led to help determine the age is the rocks. Learn the age of carbon dating is that the amount of almost anything over two thousand years old. Figuring out the age of a technique of over two thousand years, 000 years ago rocks. Fossil ages of a radioactive isotopes within those rocks of organic matter, radiometric dating can use 14c is carbon-14 or other methods. For fossils and alka tripathy-lang explain techniques for. Carbon-14 dating and state and plants, 000 years. Radioactive dating and other radioactive dating and the fossil fuels contain almost anything from the. Relative age of fossils and uranium isotopes of. Sometimes called radiometric dating when determining the scientists determine the decay rate of biological is anything organic substances. Because they then use carbon dioxide or radiocarbon ages of fossils.\nHow does carbon dating determine the age of fossils\nPast that means that is up to similar rocks on the result is that if a fossil? Thus, using radioactive isotopes of stuff scientists use radiocarbon dating of the worldview of fossil animals and whiskey, and. Sand, ted: it can be enormously important molecules. Fossils can easily establish the skull was found indirectly by its original carbon dating has three carbon dating. There are fossils faq - find out of fossil by the carbon-14 has been used by w. Clocks we can use of fossils and coal should be dated by carbon-14 in two creeks fossil.\nHow is carbon dating used to find the age of fossils", "domain": "chemistry", "round": 3} +{"url": "http://www.bio-rad.com/en-us/prime-pcr-assays/assay/qhsacip0033115-primepcr-probe-assay-kcnk3-human", "date": "2019-02-21T10:28:26Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-09/segments/1550247503844.68/warc/CC-MAIN-20190221091728-20190221113728-00239.warc.gz", "language_score": 0.8520070314407349, "token_count": 285, "dump": "CC-MAIN-2019-09", "global_id": "webtext-fineweb__CC-MAIN-2019-09__0__10733", "lang": "en", "text": "This is the amplicon context sequence in accordance with the minimum information for the publication of real-time quantitative PCR experiements (MIQE) guidelines. For more details, please refer to the following publication, \"Primer Sequence Disclosure: A Clarification of the MIQE Guidelines.\"\nReal-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.\nPrimePCR™ PreAmp for Probe Assay: KCNK3, Human\nPrimePCR™ Template for Probe Assay: KCNK3, Human\nThis gene encodes a member of the superfamily of potassium channel proteins that contain two pore-forming P domains. The encoded protein is an outwardly rectifying channel that is sensitive to changes in extracellular pH and is inhibited by extracellular acidification. Also referred to as an acid-sensitive potassium channel it is activated by the anesthetics halothane and isoflurane. Although three transcripts are detected in northern blots there is currently no sequence available to confirm transcript variants for this gene. [provided by RefSeq Aug 2008]\nProducts used to generate validation data:\nAmplification of cDNA generated from universal RNA.\nMelt curve analysis of above amplification.\nStandard curve generated using 20 million copies of template diluted 10 fold to 20 copies.", "domain": "chemistry", "round": 3} +{"url": "https://pubmed.ncbi.nlm.nih.gov/23307347/?dopt=Abstract", "date": "2024-03-05T06:31:16Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707948223038.94/warc/CC-MAIN-20240305060427-20240305090427-00603.warc.gz", "language_score": 0.884061336517334, "token_count": 419, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__55978289", "lang": "en", "text": "Purpose: Quantitative prediction of complex drug-drug interactions (DDIs) is challenging. Repaglinide is mainly metabolized by cytochrome-P-450 (CYP)2C8 and CYP3A4, and is also a substrate of organic anion transporting polypeptide (OATP)1B1. The purpose is to develop a physiologically based pharmacokinetic (PBPK) model to predict the pharmacokinetics and DDIs of repaglinide.\nMethods: In vitro hepatic transport of repaglinide, gemfibrozil and gemfibrozil 1-O-β-glucuronide was characterized using sandwich-culture human hepatocytes. A PBPK model, implemented in Simcyp (Sheffield, UK), was developed utilizing in vitro transport and metabolic clearance data.\nResults: In vitro studies suggested significant active hepatic uptake of repaglinide. Mechanistic model adequately described repaglinide pharmacokinetics, and successfully predicted DDIs with several OATP1B1 and CYP3A4 inhibitors (<10% error). Furthermore, repaglinide-gemfibrozil interaction at therapeutic dose was closely predicted using in vitro fraction metabolism for CYP2C8 (0.71), when primarily considering reversible inhibition of OATP1B1 and mechanism-based inactivation of CYP2C8 by gemfibrozil and gemfibrozil 1-O-β-glucuronide.\nConclusions: This study demonstrated that hepatic uptake is rate-determining in the systemic clearance of repaglinide. The model quantitatively predicted several repaglinide DDIs, including the complex interactions with gemfibrozil. Both OATP1B1 and CYP2C8 inhibition contribute significantly to repaglinide-gemfibrozil interaction, and need to be considered for quantitative rationalization of DDIs with either drug.", "domain": "chemistry", "round": 3} +{"url": "https://www.jairadhesales.co.in/oxymetazoline-hcl-933660.html", "date": "2023-09-22T09:24:29Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233506339.10/warc/CC-MAIN-20230922070214-20230922100214-00534.warc.gz", "language_score": 0.7252508997917175, "token_count": 300, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__164512922", "lang": "en", "text": "NAME :- OXYMETAZOLINE HCL\nIUPAC NAME :- 6-tert-butyl-3-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2,4-dimethylphenol hydrochloride\nCAS NO. :- 2315-02-8\nFORMULA :- C16H24N2O HCL\nSYNONYMS :- Oxymetazoline HCl; Afrazine; 2-(4-tert-butyl-3-hydroxy-2,6-dimethylbenzyl)-4,5-dihydro-1H-imidazol-3-ium\nAPPLICATION :- Is an 1-AR and 2-AR adrenergic receptor agonist.\nDESCRIPTION :- Oxymetazoline Hydrochloride is a direct sympathomimetic agent. Is a nonselective adrenomimetic of 1A-AR and 2A-AR (1-AR and 2-AR adrenergic receptor) agonists. Since vascular beds widely express 1 receptors, the action of Oxymetazoline results in vasoconstriction due to its action on endothelial 2 receptors. Oxymetazoline Hydrochloride is an inhibitor of SR-2C and an activator of SR-1A, SR-1B, SR-1D and SR-2C.", "domain": "chemistry", "round": 3} +{"url": "https://m.scirp.org/papers/790", "date": "2022-08-14T21:30:03Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882572077.62/warc/CC-MAIN-20220814204141-20220814234141-00665.warc.gz", "language_score": 0.6539772152900696, "token_count": 1408, "dump": "CC-MAIN-2022-33", "global_id": "webtext-fineweb__CC-MAIN-2022-33__0__8123198", "lang": "en", "text": "K. Jalava, S. Nikkari, J. Jalava, E. Eerola, M. Skurnik, O. Meurman, O. Ruuskanen, A. Alanen, E. Kotilainen, P. Toivanen, and P. Kotilainen, (2000) Direct amplification of rRNA genes in diagnosis of bacterial infections, J. of Clinical Microbiology, 38, 32–39.\nJ. Wang, G. Rivas, C. Parrado, X. Cai, and M. N. Flair, (1997) Electrochemical biosensor for detecting DNA sequences from the pathogenic protozoan Cryptosporidium parvum, Talanta, 44, 2003–2010.\nM. Passamano and M. Pighini, (2006) QCM DNA- sensor for GMOs detection, Sensors and Actuators B, 118, 177–181.\nA. Rang, B. Linke, and B. Jansen, (2005) Detection of RNA variants transcribed from the transgene in Roundup ready soy-bean, Eur. Food Res. Tech., 220, 438–443.\nJ. Wang, G. Rivas, X. Cai, E. Palecek, P. Nielsen, H. Shiraishi, N. Dontha, D. Luo, C. Parrado, M. Chicharro, P. A. M. Farias, F. S. Valera, D. H. Grant, M. Ozsoz, and M. N. Flair, (1997) DNA electrochemical biosensors for environmental monitoring, Analytical Chemical Act., 347, 1–8.\nY. Lu, J. Liu, J. Li, P. J. Bruesehoff, C. M. B. Pavot, and A. K. Brown, (2003) New highly sensitive and selective catalytic DNA biosensors for metal Ions, Biosensors and Bioelectronics, 18, 529–540.\nP. Rossmanith, M. Krassnig, M. Wagner, and I. Hein, (2006) Detection of Listeria monocytogenes in food using a combined enrichment/real-time PCR method targeting the prfA gene, Research in Microbiology, 157, 763–771.\nK. E. Yoder and R. Fishel, (2006) PCR-based detection is un-able to consistently distinguish HIV 1LTR circles, Journal of Virological Methods, 138, 201–206.\nB. D. Rio, A. G. Binetti, M. C. Martín, M. Fernández, A. H. Magadán, and M. A. Alvarez, (2007) Multiplex PCR for the detection and identification of dairy bacteriophages in milk, Food Microbiology, 24, 75–81.\nI. Mannelli, M. Minunni, S. Tombelli, and M. Mascini, (2003) Quartz crystal microbalance (QCM) affinity biosensor for ge-netically modified organisms (GMOs) detection, Biosensor and Bioelectronics, 18, 129–140.\nX. D. Zhou, L. J. Liu, M. Hu, L. L. Wang, and J. M. Hu, (2002) Detection of hepatitis B virus by piezoelectric biosensor, J. Pharm. and Biomed. Anal, 27, 341–345.\nR. Epstein, I. Biran, and D. R. Walt, (2002) Fluorescence- based nucleic acid detection and micro arrays, Anal. Chimica Acta., 469, 3–36.\nT. Jiang, M. Minunni, P. Wilson, J. Zhang, A. P. F. Turner, and M. Mascini, (2005) Detection of TP53 mutation using a portable surface plasmon resonance DNA- based biosensor, Biosensors and Bioelectronics, 20, 1939–1945.\nK. Yamashita, Y. Yamaguchi, M. Miyazaki, H. Nakamura, H. Shimizu, and H. Maeda, (2004) Microfluidic system for DNA sequence detection, Chem. Eng. Journal, 101, 157–161.\nP. D. Thanh, M. A. Tuan, N. D. Chien, and C. Jean-Marc, (2004) Investigation on interferences of conductometric bio-sensor using tyrosinase enzyme, in Proc. 7th Vietnam-ese-German Seminar on Physics and Engineering, Vietnam, 158–161.\nJ. Wang, M. Jiang, A. Fortes, and B. Mukherjee, (1999) New label-free DNA recognition based on doping nucleic-acid probes within conducting polymer films, Anal. Chim. Acta, 402, 7–12.\nH. A. Tajmir-Riahi, (2006) An overview of protein- DNA and protein-RNA interactions, J. of the Iranian Chem. Soc., 3, 297–304.\nY. Zhou and Y. Li, (2004) Studies of interaction between poly (allylamine hydrochloride) and double helix DNA by spectral methods, Biophysical Chemistry, 107, 273–281.\nL. S. Andréa and O. A. S. Maria, (2007) Electrodeposition of polypyrrole films on aluminum from tartrate aqueous solution, J. Braz. Chem. Soc., 18, 143–152.\nM. Omastová, J. Pionteck, and S. Koina, (1996) Preparation and characterization of electrically conductive polypropyl-ene/polypyrrole composites, Eur. Polym. J., 32, 681– 689.\nH. N. Cong, K. E. Abbassi, J. L. Gautier, and P. Chartier, (2005) Oxygen reduction on oxide/polypyrrole composite electrodes: effect of doping anions, Electrochimica Acta., 50, 136–1376.", "domain": "chemistry", "round": 3} +{"url": "http://www.kuraka.co.jp/en/product/industrial/high_buffer/01/index.html", "date": "2018-09-24T07:39:26Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-39/segments/1537267160233.82/warc/CC-MAIN-20180924070508-20180924090908-00085.warc.gz", "language_score": 0.8818156123161316, "token_count": 317, "dump": "CC-MAIN-2018-39", "global_id": "webtext-fineweb__CC-MAIN-2018-39__0__143705858", "lang": "en", "text": "KUB Urethane Form Shock Absorber\nA Shock Cushioning Material which Demonstrates High Shock Absorbing Performance\nHi-Buffer KUB is a shock cushioning material composed of urethane-form elastomer.\nThe urethane form elastomer has a unique bubble structure which could greatly fluctuate its shape, therefore, a low impact force has been demonstrated while showing a high energy absorption capability.\n- Performance &\n- Specifications &\nHigh Cushioning Performance\nThis bubble structure exhibits a deflection rate two times than that of the normal elastomer. Due to this, it is possible for hi-buffer to reduce collision energy using a large stroke and to relax an impact force low.\nLow Lateral Swelling\nWhen a urethane form is compressed, the internal bubbles are also compressed, therefore, the lateral side protrusion of the cushioning material can be minimized. When the compression rate is 70%, the increase of external contour is approximately 30%, which is approximately 1/3 of the natural rubber.\n- *Painting: Urethane paint, Standard color: Munsell 2.5YR3/8 (In the case of custom orders, please specify the color number based on the standard paint color samples of Japan Paint Manufacturers Association)\n- *The product numbers of the safety nets are indicated by \"N\" at the end of each product number of KUB products. Please order together with the main unit (i.e.: KUB-315-5N)", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/traf1-antibody-ab155268.html", "date": "2020-08-05T04:23:30Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-34/segments/1596439735909.19/warc/CC-MAIN-20200805035535-20200805065535-00216.warc.gz", "language_score": 0.734388530254364, "token_count": 648, "dump": "CC-MAIN-2020-34", "global_id": "webtext-fineweb__CC-MAIN-2020-34__0__42460758", "lang": "en", "text": "Key features and details\n- Rabbit polyclonal to TRAF1\n- Suitable for: WB, IHC-P\n- Reacts with: Human\n- Isotype: IgG\nProduct nameAnti-TRAF1 antibody\nSee all TRAF1 primary antibodies\nDescriptionRabbit polyclonal to TRAF1\nTested applicationsSuitable for: WB, IHC-Pmore details\nSpecies reactivityReacts with: Human\nRecombinant protein fragment, corresponding to a region within amino acids 1-228 of Human TRAF1 (Uniprot ID Q13077)\n- Raji cell lysate; Human SW480 xenograft tissue.\nStorage instructionsShipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.\nStorage bufferpH: 7.00\nPreservative: 0.01% Thimerosal (merthiolate)\nConstituents: 1.21% Tris, 0.75% Glycine, 20% Glycerol\nConcentration information loading...\nPurityImmunogen affinity purified\nOur Abpromise guarantee covers the use of ab155268 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\n|WB||1/500 - 1/3000. Predicted molecular weight: 46 kDa.|\n|IHC-P||1/100 - 1/1000. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. Antigen retrieval also possible using Tris-EDTA buffer (pH8.0).|\nFunctionAdapter molecule that regulates the activation of NF-kappa-B and JNK. Plays a role in the regulation of cell survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14. The TRAF1/TRAF2 complex recruits the antiapoptotic E3 protein-ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2.\nSequence similaritiesContains 1 MATH domain.\nDomainThe coiled coil domain mediates homo- and hetero-oligomerization.\nThe MATH/TRAF domain binds to receptor cytoplasmic domains.\nCleavage by CASP8 liberates a C-terminal fragment that promotes apoptosis and inhibits the activation of NF-kappa-B in response to TNF signaling.\nmodificationsPolyubiquitinated by BIRC2 and/or BIRC3, leading to its subsequent proteasomal degradation.\n- Information by UniProt\n- 4732496E14Rik antibody\n- EBI6 antibody\n- EBV induced protein 6 antibody\nab155268 has not yet been referenced specifically in any publications.", "domain": "chemistry", "round": 3} +{"url": "https://www.oxygennitrogengenerator.com/sale-29567809-anti-explosion-psa-liquid-nitrogen-generation-plant-0-6mpa-n2-membrane-unit.html", "date": "2023-03-29T22:21:30Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-14/segments/1679296949035.66/warc/CC-MAIN-20230329213541-20230330003541-00478.warc.gz", "language_score": 0.8181450366973877, "token_count": 784, "dump": "CC-MAIN-2023-14", "global_id": "webtext-fineweb__CC-MAIN-2023-14__0__285553179", "lang": "en", "text": "|Product-Name:||Nitrogen Production Plant||Production Rate:||10Nm3/h-2000Nm3/h|\n|Capaicty:||5-5000 Nm3/h||Feature:||Eco Friendly|\nAETOK Anti Explosion liquid nitrogen generation plant,\nAETOK PSA liquid nitrogen generation plant,\nAETOK 0.6mpa n2 membrane unit\nPressure Swing Adsorption Membrane Nitrogen Generator Anti Explosion\nPsa Nitrogen Plant Flow\n(1) .air compressing system, this system includes air compressor, air buffer tank, the purpose of this syetem is to compress the normal pressure air to high pressure air.\n(2). air purification system, this system includes degreaser, refrigerated(adsorption)dryer,ultrafilter,active carbon filter,the purpose of this system is to remove dust,water and oil in the compressed air to make sure the compressed air will be clean and dry in the following steps.\n(3). air buffer tank. This system includes air compressing buffer tank,the purpose of this system is to store the compressed gas to make sure the stable supply of gas for O2/N2 separation system,mainly composed of air tank and valves.\n(4). Adsorption separation system,this system includes adsorber tower,Program control valve,controller,analysis meter, also this is the most important system for all the production line, the purpose of this system is to produces N2 through PSA technology,composed of two adsorption towers filled with carbon molecular sieve and automatic control valves\n(5). buffering and emptying system,this system includes Nitrogen gas buffer tank,flfter,pressure regulating valve,flow gauge, emptying system.the purpose of this system is to store the finished N2 and regulate the pressure for the request,and change the flow of the N2.\n|N2 flow rate||1200Nm3/h||Standard state|\n|N2 purity||≥95.0%||non-oxygen content|\n|N2 outlet pressure||0.1~0.6Mpa||Gage pressure, adjustable|\n|N2 outlet dew point||≤ 45 °C||Atmospheric dew point|\nAdvantages of PSA nitrogen generator:\n1. Skid-mounted design, small required installed area.\n2. Energy saving, low operationg cost.\n3. Easy to operate, turn on and off according to the oxygen demand.\n4. Long running time, low maintenance cost.\n5. Automatic control, completely unattended.\n6. Cylinder filling station (Optional).\n7. Installation is very easy, provide technical support at any time.\nPsa Nitrogen Plant Application:\nQ1. Are you a manufacturer or a trading company?\nA1: We are a professional manufacturer in the gas industry for more than 20 years.\nQ2. What are your terms of payment?\nA2: T/T 40% as deposit, and 60% T/T or L/C at the sign before delivery. Welcome to inspect the products before you pay the balance.\nQ3. Can you produce according to the client's requests?\nA: Yes, we can produce by your request or technical drawings. We can build the molds and fixtures.\nQ4. How about your delivery time?\nA4: Generally 30-45 days.\nContact Person: admin", "domain": "chemistry", "round": 3} +{"url": "https://www.dailygrindfitnesscompany.com/blogs/news/chromium-supplements", "date": "2022-05-25T19:17:10Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-21/segments/1652662593428.63/warc/CC-MAIN-20220525182604-20220525212604-00252.warc.gz", "language_score": 0.9002704620361328, "token_count": 943, "dump": "CC-MAIN-2022-21", "global_id": "webtext-fineweb__CC-MAIN-2022-21__0__120028034", "lang": "en", "text": "What chromium is: A necessary hint mineral, chromium is necessary in processing carbohydrates and fat and it helps cells reply correctly to insulin—the hormone produced within the pancreas that makes blood sugar obtainable to the cells as our primary gas. Nobody understands the precise position of chromium in all this. Chromium dietary supplements are available in a number of kinds, by no means as pure chromium. You should purchase chromium picolinate, chromium chloride, chromium nicotinate and high-chromium yeast. Nicotinate and picolinate appear extra simply absorbed than the opposite kinds.\nClaims, purported advantages: Builds muscle, prevents and treats diabetes, promotes weight reduction.\nChromium: the newest analysis\nThe impact of chromium supplementation could also be extremely variable due to particular person reactions to the mineral. Genetic and ethnic elements could play a job, together with diploma of insulin resistance.\nWeight reduction. Chromium could have a possible position in weight management, however to date essentially the most carefullyconducted research have didn’t discover a profit. As an example, in a examine revealed within the journal Dietin 2007, ladies taking 200 micrograms of chromium a day for 12 weeks didn’t lose moreweight or physique fats (or construct extra muscle) than the placebo group. A 2013 systemic evaluate andmeta-analysis in Weight problems Evaluations, which included 20 trials lasting eight to 26 weeks, discovered thatchromium dietary supplements resulted in a median weight lack of one pound, which isn’t clinicallysignificant, and had no impact on physique mass index or waist circumference.\nDiabetes. Low ranges of chromium are attribute of diabetes, though there isn’t a evidencethat a low chromium degree causes diabetes. Some research have reported that chromium picolinate supplementation in doses of 200 micrograms is useful; nevertheless, others haven’t. Onelarge scientific trial in China discovered that chromium helped individuals with diabetes—however the Chineseare much less prone to be overweight than People, and their chromium ranges weren’t evaluated at thestart of the examine. Medical trials involving People with diabetes have produced inconsistentresults. A Dutch examine in Diabetes Care discovered no enchancment in blood sugar or any otherbenefits in individuals with kind 2 diabetes who took chromium within the type of enriched yeast forsix months.\nThe latest meta-analysis, revealed within the Journal of Pharmacy & Pharmaceutical Sciences in 2013,discovered that whereas chromium dietary supplements decrease fasting blood sugar, they don’t scale back HbA1c(glycated hemoglobin). HbA1c is a marker for common degree of blood sugar concentrations overthe earlier months and is the very best measure of long-term diabetes management.\nCoronary heart illness. Research of chromium dietary supplements and levels of cholesterol have proven no constant profit. If you’re chromium poor, you may have the ability to scale back your LDL (“dangerous”)ldl cholesterol and lift your HDL (“good”) ldl cholesterol considerably with chromium dietary supplements.However even that may be a large “may.” And there are higher methods to enhance your levels of cholesterol,together with weight-reduction plan, train and cholesterol-lowering medication.\nTrain.Chromium picolinate is promoted for constructing muscle and lowering physique fats. Butstudies have yielded inconsistent outcomes. A 2013 analysis evaluate within the Journal of theInternational Society of Sports activities Diet concluded that chromium is seemingly ineffective asa efficiency help.\nUncomfortable side effects:Laboratory research have discovered that chromium picolinate may harm geneticmaterial in animal cells, which suggests it would trigger most cancers. Nevertheless, what occurs in a testtube or in lab animals could not occur in individuals. There have been case studies of acute kidneyfailure, liver harm and anemia in individuals taking excessive doses of chromium picolinate. Takingchromium with ache relievers equivalent to aspirin, Ibuprofen or naproxen could enhance absorptionof chromium, with unpredictable penalties, in line with a paper within the EPMA Journal in2013. Combining chromium with diabetes medicine could trigger blood sugar to dip too low.\nBackside line:Chromium is an important mineral, however deficiency is uncommon within the UnitedStates. There’s no proof that the dietary supplements carry out as claimed. Individuals with diabetesshould take chromium solely on medical recommendation.", "domain": "chemistry", "round": 3} +{"url": "https://rjptonline.org/AbstractView.aspx?PID=2008-1-2-13", "date": "2021-04-16T23:12:54Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-17/segments/1618038092961.47/warc/CC-MAIN-20210416221552-20210417011552-00022.warc.gz", "language_score": 0.911762535572052, "token_count": 497, "dump": "CC-MAIN-2021-17", "global_id": "webtext-fineweb__CC-MAIN-2021-17__0__219867859", "lang": "en", "text": "K. Shukla, S.S. Shukla, V. Jain, R. Pandey, S. Jain, Swarnlata Saraf, S. Saraf\nK. Shukla*, S.S. Shukla, V. Jain, R. Pandey, S. Jain, Swarnlata Saraf and S. Saraf\nInstitute of Pharmacy, Pt. Ravishankar Shukla University, Raipur C.G. 492010\nVolume - 1,\nIssue - 2,\nYear - 2008\nIn Ancient time when the traditional medicines were developed, standardization and quality control of Ayurvedic formulation was maintained by fully committed and professional. Due to process of evolution, commercialization and environmental effects identification and quality control of botanicals become more difficult. Other factors like cultivation, collection and environmental variation also created difficulties in standardization of traditional formulations. Chromatographic techniques like TLC, HPLC and HPTLC requires chemical markers that are therapeutically active and has its own limitations. Secondary plant metabolites that are used as marker may change due to environmental factors and hence correct identification of botanicals is a difficult task. Each herb contains large number of compounds, so it is not possible to analyze the presence or absence of all compounds quantitatively or qualitatively. These serious difficulties in testing of active principal or chemical constituents are well known. Random amplified Polymorphic DNA (RAPD) techniques based on the polymerase chain reaction (PCR) is one of the most commonly used molecular techniques to develop DNA markers. RAPD markers are amplification products of anonymous DNA sequences using single, short and arbitrary oligonucleotide primers, and thus do not require prior knowledge of a DNA sequence. Low expense, efficiency in developing large number of DNA markers in a short time and requirement of less sophisticated equipment has made the RAPD technique valuable for identification of components in traditional preparation and in development of fingerprints for traditional formulations.\nCite this article:\nK. Shukla, S.S. Shukla, V. Jain, R. Pandey, S. Jain, Swarnlata Saraf, S. Saraf. Fingerprinting of Traditional Medicines through RAPD Technology: - A Newer Approach. Research J. Pharm. and Tech. 1(2): April-June. 2008; Page 63-68.", "domain": "chemistry", "round": 3} +{"url": "https://iris.univr.it/handle/11562/1180", "date": "2017-04-26T15:44:38Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-17/segments/1492917121453.27/warc/CC-MAIN-20170423031201-00632-ip-10-145-167-34.ec2.internal.warc.gz", "language_score": 0.817376434803009, "token_count": 444, "dump": "CC-MAIN-2017-17", "global_id": "webtext-fineweb__CC-MAIN-2017-17__0__258808030", "lang": "en", "text": "Utilizza questo identificativo per citare o creare un link a questo documento:\n|Titolo:||Selective enrichment of NADPH oxidase activity in phagosomes from guinea pig polymorphonuclear leukocytes|\n|Autori interni:||BELLAVITE, Paolo|\n|Data di pubblicazione:||1982|\n|Abstract:||Recent studies have demonstrated that the activated NADPH oxidase, the enzyme responsible for the stimulation of O2 consumption with O2 formation during phagocytosis, is located in the plasma membrane of leukocytes. The present work deals with whether the activation induced by phagocytosis involves the enzyme of the entire membrane or only that of the portion of the membrane that interacts with the phagocytosable particle and forms the phagosome. The results presented show that the activity of the NADPH oxidase of phagosomal membrane, isolated by centrifugation of homogenates on discontinuous sucrose gradients, is increased 12.6-fold with respect that of homogenate. In contrast, the activities of 5'-nucleotidase and of acid p-nitrophenyl phosphatase, enzyme markers of the plasma membrane not activated during phagocytosis and uniformly distributed on the entire membrane, are increased only about three-fold with respect to that of homogenate. These results indicate that during phagocytosis and activation of NADPH oxidase is a segmentary response that involves only the enzyme that forms the phagocytic vacuole. This fact is relevant for the function of toxic intermediates of oxygen reduction that are discharged in direct contact with the engulfed agent.|\n|Appare nelle tipologie:||01.01 Articolo in Rivista|\nFile in questo prodotto:\nNon ci sono file associati a questo prodotto.\n- PubMed Central loading...\nI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.", "domain": "chemistry", "round": 3} +{"url": "https://confit.atlas.jp/guide/event/jpgu2018/subject/E_BPT04-P05/date?cryptoId=", "date": "2024-04-17T02:30:03Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712296817128.7/warc/CC-MAIN-20240417013540-20240417043540-00101.warc.gz", "language_score": 0.9039755463600159, "token_count": 309, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__24323255", "lang": "en", "text": "Keywords:foraminifer, mineralization, calcification\nForaminifera is unicellular organism with calcareous shells in ocean. The elemental composition of foraminiferal calcite is of great usage in paleoceanographic reconstructions. Even though, little is known regarding the governing biological processes of elemental uptake during calcification. The role of the organic templates are still unclear. This organic template separating the different layers of calcite that form the foraminiferal chamber wall. Further, although the function of this template is considered as crystal nucleation for chamber wall by previous studies, it is not well understood. In this study, we applied a focused ion beam (FIB) to the site of calcification of an Ammonia “beccarii”’s (benthic foraminifer) newly growing chamber to observe ultra-microscopic distribution of crystals on the organic template. Exposed cross sections of both soft and hard tissues allowing detailed time series observation of the site of calcification throughout process. We show numerous micro gaps of calcareous layers and internal appearance of organic structures are present within the site of calcification during calcification process. The series of SEM observations suggest that organic layers are actively involved in calcite precipitation. We provide the evidence that the site of calcification is enclosed from surrounding seawater during calcification. Our findings improve the understanding of foraminiferal biomineralization and characterize the conditions under which element partitioning and isotope fractionation occur.", "domain": "chemistry", "round": 3} +{"url": "https://www.answers.com/Q/How_much_coal_is_used", "date": "2022-11-28T11:00:18Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-49/segments/1669446710503.24/warc/CC-MAIN-20221128102824-20221128132824-00769.warc.gz", "language_score": 0.9718809723854065, "token_count": 274, "dump": "CC-MAIN-2022-49", "global_id": "webtext-fineweb__CC-MAIN-2022-49__0__145532888", "lang": "en", "text": "Titanic used about 5, 900 tons of coal.\nthe titanic used 850 tonnes of coal each day\nYes,once its used as much oil and coal power station\nit used a lot of coal to heat your mom! (8,000 tons a day)\nwell it depends, in most coal yards they have feeders that measure how much coal is put into the cars.\nit used 9000 bags of coal just to america .......................mohammed....... from hazelwick\nHow did they used to coal mine\nThere are various uses of coal out of which 85% of coal is burned to generate electricity. The ash is sometimes used in building products. Much coal is converted to coke, which is largely used to make steel. Some coal is used to make natural gas, and CTL (Coal to liquid) processes coming on line can make gasoline or diesel fuel. Coal is also used to make many chemicals, such as medicines, paint thinner, varnish, and insecticides. There are some bye-products of coal such as coal Tar , coal tar pitch\nCoke, a carbon rich of coal.\ncoal in Zimbabwe is used for many reasons. Some of them being heat (although that is not needed much in Zimbabwe) and most of it for electrical power in Zimbabwe.", "domain": "chemistry", "round": 3} +{"url": "https://researchcommons.waikato.ac.nz/browse?type=author&value=Sissons%2C+Christopher+H.", "date": "2023-03-27T03:35:15Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-14/segments/1679296946637.95/warc/CC-MAIN-20230327025922-20230327055922-00058.warc.gz", "language_score": 0.8283979296684265, "token_count": 375, "dump": "CC-MAIN-2023-14", "global_id": "webtext-fineweb__CC-MAIN-2023-14__0__57635463", "lang": "en", "text": "Browsing by Author \"Sissons, Christopher H.\"\nNow showing items 1-3 of 3\nCellulases from extremely thermophilic bacteria Sharrock, Keith R.; Sissons, Christopher H.; Daniel, Roy M.; Morgan, Hugh W. (New Zealand Institute of Chemistry, 1983)Cellulose is the most abundant biopolymer on earth, and is the major component of urban waste. Thus cellulose must be seen as a very significant renewable source of chemical foodstocks when fossil fuels become restricted.\nComparison of cellulolytic activities in Clostridium thermocellum and Three thermophilic, cellulolytic anaerobes Reynolds, Paul H.S.; Sissons, Christopher H.; Daniel, Roy M.; Morgan, Hugh W. (American Society for Microbiology, 1986)Avicelase, carboxymethyl cellulase (CMCase), and β-glucosidase activities have been compared between Clostridium thermocellum and three extremely thermophilic, cellulolytic anaerobes, isolates TP8, TP11, and KT8. The three ...\nIsolation of cellulolytic anaerobic extreme thermophiles from New Zealand thermal sites Sissons, Christopher H.; Sharrock, Keith R.; Daniel, Roy M.; Morgan, Hugh W. (American Society for Microbiology, 1987)Avicel enrichment cultures from 47 thermal-pool sites in the New Zealand Rotorua-Taupo region were screened for growth and carboxymethyl cellulase activity at 75°C. Eight anaerobic cellulolytic cultures were obtained. The ...\nCo-authors for Christopher H. Sissons\nChristopher H. Sissons has 4 co-authors in Research Commons.", "domain": "chemistry", "round": 3} +{"url": "https://bnnbreaking.com/world/japan/single-amino-acid-difference-in-rna-helicases-reveals-unique-mrna-export-pathways", "date": "2024-04-18T11:29:31Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712296817206.28/warc/CC-MAIN-20240418093630-20240418123630-00177.warc.gz", "language_score": 0.9427010416984558, "token_count": 433, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__188874246", "lang": "en", "text": "A groundbreaking study by a team from Kindai University, led by Professor Seiji Masuda, has discovered that a single amino acid difference between two vital RNA helicases, UAP56 and URH49, results in the formation of functionally unique protein complexes involved in separate mRNA export pathways.\nRNA helicases UAP56 and URH49 are essential components of mRNA export complexes, but their distinct roles and structural differences have remained elusive. The study, published in Nature Communications, sheds light on the evolution and functional differences between these helicases, which could have significant implications for understanding and treating certain diseases.\nATP-TREX and apo-AREX: Distinct Complexes, Distinct Roles\nUAP56 is an integral part of the ATP-bound TREX complex, while URH49 has a paralogue that forms an mRNA–protein complex called apo-AREX. The researchers found that a change in a single amino acid between UAP56 and URH49 results in markedly different ATP-unbound complexes.\nThe apo-AREX complex formed by URH49 contains factors such as RUVBL1, RUVBL2, ILF2, and ILF3, which are not present in ATP-TREX complexes. These factors play a crucial role in URH49-specific mRNA transport.\nImplications for Cancer Research and Beyond\nThe study suggests that the components of these complexes may be overexpressed in cancer cells, and their aberrant expression may contribute to cancer development. This newfound understanding of the distinct roles of UAP56 and URH49 during mRNA processing and export could pave the way for further research into their potential as therapeutic targets.\nThe findings also have broader implications for our comprehension of gene regulation and the intricate interplay between RNA helicases, their complexes, and mRNA transport.\nThe groundbreaking research by Professor Masuda's team at Kindai University has uncovered a fascinating aspect of RNA helicases UAP56 and URH49, revealing that a single amino acid difference between them leads to the creation of functionally distinct protein complexes involved in separate mRNA export pathways.", "domain": "chemistry", "round": 3} +{"url": "http://repositorium.uminho.pt/browse?type=author&value=Sampaio%2C+Diogo", "date": "2023-02-08T07:48:20Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-06/segments/1674764500719.31/warc/CC-MAIN-20230208060523-20230208090523-00292.warc.gz", "language_score": 0.653915286064148, "token_count": 354, "dump": "CC-MAIN-2023-06", "global_id": "webtext-fineweb__CC-MAIN-2023-06__0__229190264", "lang": "en", "text": "Browsing by author Sampaio, Diogo Subscribe author statistics Sampaio, Diogo\nShowing results 1 to 5 of 5.\n|2013||Regiospecific synthesis of N-substituted 2-oxopurine-6-carboxamidines||Sampaio, Diogo; Dias, Alice; Proença, M. Fernanda R. P.||Abstract||Restricted access (UMinho)|\n|28-Nov-2012||Synthesis and antimycobacterial activity of 2-oxopurines||Sampaio, Diogo; Cabral, Isabel; Dias, Alice, et al.||Abstract||Restricted access (UMinho)|\n|2013||Synthesis of 6-(N-methyl)carboxamidino-2-oxopurines as potential antimycobacterial agents||Sampaio, Diogo; Martins, Andrea; Dias, Alice, et al.||Abstract||Restricted access (UMinho)|\n|Nov-2012||Ultrasonic mediated synthesis of new benzo[a]phenoxazinium chlorides and their photophysical studies||Raju, B. Rama; Sampaio, Diogo; Coutinho, Paulo J. G., et al.||Conference paper||Restricted access (UMinho)|\n|Jan-2014||Ultrasound promoted synthesis of Nile Blue derivatives||Raju, B. Rama; Sampaio, Diogo; Silva, Maria Manuela, et al.||Article||Restricted access (UMinho)|", "domain": "chemistry", "round": 3} +{"url": "https://dc.engconfintl.org/imam/24/", "date": "2022-05-20T14:25:34Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-21/segments/1652662532032.9/warc/CC-MAIN-20220520124557-20220520154557-00071.warc.gz", "language_score": 0.9157015085220337, "token_count": 436, "dump": "CC-MAIN-2022-21", "global_id": "webtext-fineweb__CC-MAIN-2022-21__0__101253078", "lang": "en", "text": "March 8 – 12, 2020\nDirect write 3D printing provides an exciting new means of generating novel structures from thermosetting resins via an additive approach. Initial efforts along these lines demonstrated the preparation of homogenous, high quality parts. More recent work has shown that it is possible to modulate the properties of these parts locally through changes in orientation of high aspect ratio fillers.\nIn this work, we present complementary developments related to resin chemistry that should provide practitioners of direct write 3D printing with additional options as far as the realization of functional gradations is concerned. This is accomplished via the creation of so-called “dual cure” resins. Here this term refers to materials that undergo thermal cure in a similar fashion to many conventional resins. Then, in a second step, the selective exposure of these materials to high energy radiation (gamma rays, electrons, etc.) results in further increases in local crosslink density, altering thermomechanical performance and providing a means of inducing arbitrary gradations in properties in a post-processing step.\nA number of different families of dual cure resins have been explored and are presented here, as well as data concerning changes in thermal and mechanical performance as a function of the details of the dual curing process. Preliminary efforts giving evidence of the generation of stable functional gradations in practice are also described. Ongoing and future efforts are focused on the optimization of these systems and the incorporation of their cure-dependent mechanical behavior into simulations in order to enable design optimization.\nDaniel F. Schmidt, Weiqing Xia, Alessandro Cassano, Scott Stapleton, and Sara Najafian, \"New developments in dual cure epoxies\" in \"Innovative Materials For Additive Manufacturing (IMAM)\", Daniel Schmidt, Luxembourg Institute of Science and Technology, Luxembourg Nikhil Gupta, New York University, USA Chua Chee Kai, NTU, Singapore Brett G. Compton, University of Tennessee, USA Eds, ECI Symposium Series, (2020). https://dc.engconfintl.org/imam/24", "domain": "chemistry", "round": 3} +{"url": "https://www.azomining.com/News.aspx?newsID=1757", "date": "2023-03-24T00:53:05Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-14/segments/1679296945218.30/warc/CC-MAIN-20230323225049-20230324015049-00336.warc.gz", "language_score": 0.9262475967407227, "token_count": 693, "dump": "CC-MAIN-2023-14", "global_id": "webtext-fineweb__CC-MAIN-2023-14__0__31263319", "lang": "en", "text": "Latin American Minerals Inc. (TSX VENTURE:LAT) has announced the acquisition of a 100% interest in the Chiriguelo Project in northeast Paraguay.\nThe property consists of an exploration concession for which technical approval and environmental permitting have been received from the Paraguayan government.\nThe Chiriguelo Carbonatite Complex represents a prime exploration target for Niobium and Rare Earth Elements (REEs) in northeastern Paraguay.\nThe 25,500 hectare Chiriguelo exploration concession is held by the Corporation through its Paraguayan subsidiary Minera Itapora S.A. The Chiriguelo Project is located approximately 500 kilometers northeast of Asuncion. Vehicle access is available through the prospect on paved road.\nThe primary niobium producing ore 'pyrochlore' has been found in abundance at Chiriguelo, both at surface and in historic drilling. Worldwide production of niobium is limited, with the main production occurring in Brazil at deposits geologically similar to Chiriguelo. The principal uses for niobium are to produce special steel alloys for critical applications such as gas pipelines, and also to produce high-strength super alloys for high temperature applications.\nThe Corporation has conducted initial surface sampling that verifies an area with high niobium concentrations measuring 600m x 150m within the central carbonatite body.\nAbundant concentrations of Rare Earth Oxides have also been located at surface and in trenches at the Chiriguelo deposit. The suite of rare earth elements have a variety commercial applications related to: advanced technologies such as super-conductors, lighting equipment and lasers, optical pigments and catalysts in chemical processes.\nThe Corporation's initial sampling of Rare Earth Oxides (REO) has demonstrated relatively large proportions of Lanthanum (32.8% of total REO), Cerium (47.3%), Praseodymium (4.4%), and Neodymium (11.9%). Samarium (1.12% of total REO), Europium (0.27%), Gadolinium (1.33%), Dysprosium (0.44%) and Erbium (0.28%) have also been encountered in the REO samples tested to date.\nThe occurrences of niobium and Rare Earth Oxides in the Corporation's surface samples compare favorably with several producing mines.\nMiles Rideout, the President and CEO of Latin American Minerals stated that: \"Although we are still putting together a picture of the Chiriguelo target potential, the geological evidence supports a large intrusive source with pyrochlore below the current niobium anomaly on surface. The initial testing of the North Fenite Rim target has produced values of various rare earth elements at levels that are comparable with several REE mines in production. Given these impressive results at this early stage of field work, the Chiriguelo Project shows good potential to produce a sizable niobium/REE deposit.\"\nParaguay has good social conditions and infrastructure to support construction of new mines. Though underexplored, Paraguay has favorable regulations for investment, mine development and exports. The Corporation's Paso Yobai Gold Project and Itapoty Diamond Project are also located in Paraguay.\nSource: Latin American Minerals Inc.", "domain": "chemistry", "round": 3} +{"url": "https://www.chemanalyst.com/NewsAndDeals/NewsDetails/exxonmobil-reinitiates-paraxylene-manufacturing-operations-in-united-states-25294", "date": "2024-04-19T02:42:41Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712296817253.5/warc/CC-MAIN-20240419013002-20240419043002-00717.warc.gz", "language_score": 0.9321252703666687, "token_count": 588, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__82163845", "lang": "en", "text": "ExxonMobil Reinitiates Paraxylene Manufacturing Operations in United States\n- 16-Feb-2024 2:57 PM\n- Journalist: Rene Swann\nExxonMobil, a prominent United States company, has recently resumed paraxylene production at its facility located in Beaumont, Texas. The facility boasts a substantial production capacity of 315 thousand tons of paraxylene annually, contributing to approximately 12% of the total paraxylene production capacity in the United States.\nThe decision to restart paraxylene production is speculated to be driven by a surge in demand for fuel. Traditionally, the demand for gasoline experiences an uptick during the summer months, attributed to increased consumer usage for summer vacations and road trips. This scenario often prompts companies in the petrochemical industry to adjust their production levels to meet the heightened demand for fuel-related products.\nParaxylene, a key product in this context, plays a pivotal role as a primary raw material for the production of purified terephthalic acid (TPA). Additionally, it finds application in various markets, including dimethyl terephthalate (DMT), diparaxylene, herbicides, and solvents. Both TPA and DMT are crucial components in the manufacturing process of polyethylene terephthalate (PET), a widely used polymer in the production of plastic bottles and other packaging materials.\nIt's noteworthy that a significant portion of paraxylene, approximately 98%, is utilized in the production of polyester, underlining its central role in the textile and packaging industries. Furthermore, DMT, another key derivative of paraxylene, is employed in the production of polybutylene terephthalate (PBT) resin, extending its applications to a broader range of industrial and consumer goods.\nWithin the United States, major players in the paraxylene production landscape include ExxonMobil, Flint Hills Resources, Indorama, and INEOS Aromatics. Each of these companies contributes to the overall production capacity, with ExxonMobil being a noteworthy participant in the market.\nThe decision to resume paraxylene production aligns with the dynamics of the petrochemical industry, where production adjustments are made in response to market demands and seasonal fluctuations. As the summer months typically witness an increased need for gasoline, ExxonMobil's strategic move to restart paraxylene production reflects its adaptability to market dynamics and its commitment to meeting the evolving demands of consumers.\nExxonMobil's resumption of paraxylene production at its Beaumont facility in Texas not only addresses the current market needs but also underscores the company's role as a key player in the United States petrochemical landscape. As the demand for fuel-related products continues to fluctuate, the ability of companies such as ExxonMobil to adapt and respond to these changes remains crucial for maintaining a stable and efficient production environment within the petrochemical sector.", "domain": "chemistry", "round": 3} +{"url": "http://www.innovations-report.com/html/reports/life-sciences/european-union-sponsors-fabrication-molecular-221931.html", "date": "2016-10-23T15:09:44Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2016-44/segments/1476988719273.38/warc/CC-MAIN-20161020183839-00386-ip-10-171-6-4.ec2.internal.warc.gz", "language_score": 0.8872496485710144, "token_count": 1114, "dump": "CC-MAIN-2016-44", "global_id": "webtext-fineweb__CC-MAIN-2016-44__0__182714640", "lang": "en", "text": "Professor Angelika Kühnle and her work group at the Institute of Physical Chemistry at Johannes Gutenberg University Mainz (JGU) are participating in a new EU project focusing on information and communication technology.\nOver the next four years, a total of eight partners from six European countries will be involved in the \"Planar Atomic and Molecular Scale Devices\" (PAMS) project. The goal is to manufacture planar electronic components to enable technological and scientific research to be conducted at the atomic or sub-molecular level. Kühnle's work group will receive some EUR 700,000 in funding under the 7th EU Research Framework Program.\nThe purpose of the PAMS project is to design electronic components that will be at a scale below the sub-nanometer range, in other words, in the atomic range. In order to do so, existing tools need to be further developed so that the necessary building blocks, such as nano wires and nano pads, can be connected and manipulated at low temperatures. Among the core aims of the research project is to understand the electronic functioning of these nano wires and the contacts between the various components for further improvement.\nThe Mainz-based team will focus on the synthesis of tailored molecular components. \"We will be producing molecular structures on surfaces that, for example, will be used as molecular wires. The essential requirement is that these structures need to be directly synthesized on a non-conducting or semi-conducting carrier layer,\" explained Kühnle. \"For this purpose, our cooperation partners will synthesize tailored precursor molecules with clearly defined properties.\"\nThe precursor molecules will then be attached to isolating or semi-conducting surfaces under controlled conditions in an ultra-high vacuum environment. The next step will be to activate the precursor molecules on the surfaces by means of exposure to high temperatures or light irradiation. This should trigger a reaction that links the molecules, resulting in a stable, interlinked molecular component on the surface of the material.\nAlso participating in the EU project \"Planar Atomic and Molecular Scale Devices\" under supervision of Professor André Gourdon of the Centre National de la Recherche Scientifique (CNRS) in Toulouse, France, will be, in addition to Johannes Gutenberg University Mainz, the Jagiellonian University in Kraków, Poland, Dresden University of Technology, Germany, the University of Santiago de Compostela, Spain, the Spanish National Research Council in Madrid, Aalto University in Finland, and the IBM Research GmbH in Rüschlikon, Switzerland.\nPetra Giegerich | idw\nNovel mechanisms of action discovered for the skin cancer medication Imiquimod\n21.10.2016 | Technische Universität München\nSecond research flight into zero gravity\n21.10.2016 | Universität Zürich\nResearchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.\n\"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits,\" said Jeremy Béjanin, a PhD...\nIn a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.\nA research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...\nBy forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.\n\"People have already built small quantum computers,\" says Sandia researcher Ryan Camacho. \"Maybe the first useful one won't be a single giant quantum computer...\nCOMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.\nIn 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...\n'Ferroelectric' materials can switch between different states of electrical polarization in response to an external electric field. This flexibility means they show promise for many applications, for example in electronic devices and computer memory. Current ferroelectric materials are highly valued for their thermal and chemical stability and rapid electro-mechanical responses, but creating a material that is scalable down to the tiny sizes needed for technologies like silicon-based semiconductors (Si-based CMOS) has proven challenging.\nNow, Hiroshi Funakubo and co-workers at the Tokyo Institute of Technology, in collaboration with researchers across Japan, have conducted experiments to...\n14.10.2016 | Event News\n14.10.2016 | Event News\n12.10.2016 | Event News\n21.10.2016 | Health and Medicine\n21.10.2016 | Information Technology\n21.10.2016 | Materials Sciences", "domain": "chemistry", "round": 3} +{"url": "https://apps.dtic.mil/docs/citations/ADA266205", "date": "2020-04-03T17:24:49Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-16/segments/1585370515113.54/warc/CC-MAIN-20200403154746-20200403184746-00467.warc.gz", "language_score": 0.709017276763916, "token_count": 404, "dump": "CC-MAIN-2020-16", "global_id": "webtext-fineweb__CC-MAIN-2020-16__0__54152937", "lang": "en", "text": "Accession Number : ADA266205\nTitle : Kinetics of Semiconductor Surface Chemistry: Silicon Atomic Layer Processing\nDescriptive Note : End-of-the-year rept.\nCorporate Author : COLORADO UNIV AT BOULDER DEPT OF CHEMISTRY AND BIOCHEMISTRY\nPersonal Author(s) : George, Steven M\nReport Date : May 1993\nPagination or Media Count : 19\nAbstract : Surface Kinetics play a crucial role in semiconductor processing chemistry. Our research concentrates on fundamental understanding of microscopic surface kinetics that dictate surface chemistry. We are exploring the various adsorption, decomposition, diffusion and desorption steps in reactions on single-crystal silicon surfaces. These basic time-dependent surface processes are examined using laser induced thermal desorption (LITD) and Fourier transform infrared (FTIR) techniques. These techniques provide direct, quantitative measurements of surface coverage in real-time. Atomic layer processing is a vital need for semiconductor fabrication. As the size of electronic devices approaches the nanometer scale, the need to control growth on an atomic scale is extremely important. For the construction of next generation devices, controlled atomic layer-by-layer processing during oxidation, growth, etching and metallization is critical.\nDescriptors : *SEMICONDUCTORS , *SILICON , *KINETICS , *SURFACE CHEMISTRY , THERMAL PROPERTIES , LAYERS , ADSORPTION , DESORPTION , ATOMIC PROPERTIES , METALLIZING , DECOMPOSITION , DIFFUSION , ETCHING , OXIDATION , LASERS , PROCESSING , SINGLE CRYSTALS\nSubject Categories : Physical Chemistry\nElectrical and Electronic Equipment\nAtomic and Molecular Physics and Spectroscopy\nDistribution Statement : APPROVED FOR PUBLIC RELEASE", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/rbm23-antibody-ab69331.html", "date": "2020-08-14T11:33:19Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-34/segments/1596439739211.34/warc/CC-MAIN-20200814100602-20200814130602-00345.warc.gz", "language_score": 0.7016961574554443, "token_count": 455, "dump": "CC-MAIN-2020-34", "global_id": "webtext-fineweb__CC-MAIN-2020-34__0__158063278", "lang": "en", "text": "Key features and details\n- Mouse polyclonal to RBM23\n- Suitable for: WB\n- Reacts with: Human\n- Isotype: IgG\nProduct nameAnti-RBM23 antibody\nDescriptionMouse polyclonal to RBM23\nTested applicationsSuitable for: WBmore details\nSpecies reactivityReacts with: Human\nFull length human RBM23 protein (AAH02566).\n- RBM23 transfected 293T lysate.\nStorage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.\nStorage bufferpH: 7.20\nConstituent: 2.68% PBS\nConcentration information loading...\nPurityProtein G purified\nOur Abpromise guarantee covers the use of ab69331 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\n|WB||1/500 - 1/1000. Detects a band of approximately 50 kDa (predicted molecular weight: 47 kDa).|\nFunctionProbable RNA-binding protein. May be involved in pre-mRNA splicing process.\nSequence similaritiesBelongs to the splicing factor SR family.\nContains 2 RRM (RNA recognition motif) domains.\n- Information by UniProt\n- CAPERbeta antibody\n- FLJ10482 antibody\n- MGC4458 antibody\nAll lanes : Anti-RBM23 antibody (ab69331) at 1/500 dilution\nLane 1 : RBM23 transfected 293T lysate\nLane 2 : Non-transfected 293T lysate\nLysates/proteins at 25 µg per lane.\nAll lanes : Goat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilution\nPredicted band size: 47 kDa\nObserved band size: 50 kDa why is the actual band size different from the predicted?\nab69331 has not yet been referenced specifically in any publications.", "domain": "chemistry", "round": 3} +{"url": "https://www.atminhibitor.com/2023/09/24/12317/", "date": "2023-12-09T08:36:27Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100873.6/warc/CC-MAIN-20231209071722-20231209101722-00537.warc.gz", "language_score": 0.9182980060577393, "token_count": 947, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__250343548", "lang": "en", "text": "PKCη Activator medchemexpress protein that is certainly transported for the lysosome within a MPR-dependent manner.DISCUSSION\nPKCη Activator medchemexpress protein that is certainly transported for the lysosome within a MPR-dependent manner.DISCUSSION In 2005, four novel putative sulfatases (termed arylsulfatase H, I, J, and K) have been identified bioinformatically in humans by a genome-wide screen using the sulfatase-specific signature sequence (2). Arylsulfatase I and arylsulfatase J is often thought of paralogs of arylsulfatase B because of their higher sequence identity (45 at the protein level). In contrast, arylsulfatase K shows low sequence identity (18 ?two ) with other known sulfatases (2). In spite of this divergence from other sulfatases, ARSK itself is really strongly conserved, e.g. human ARSK shows 76 sequence identity to chicken, 62 to zebrafish, 54 to amphioxus, and 52 to acorn worm. This conservation strengthens the prediction that ARSK has a crucial and conserved function. Right here we demonstrate that human ARSK is usually a ubiquitously expressed glycoprotein that resides within the lysosome and cleaves artificial arylsulfate pseudosubstrates. ARSK was stably expressed in human cell lines as a Histagged derivative and exhibited an apparent molecular mass of 68 kDa in its intracellular kind and also a slightly larger molecular mass of 70 kDa when secreted into medium. Deglycosylation assays applying endoglycosidases PNGaseF and EndoH clearly demonstrated that each intracellular and extracellular ARSK carry multiple complex-type also as mannose-rich-type asparagine-linked glycans. The reduction in size of ten kDa just after PNGaseF remedy suggests occupation of four to 5 in the seven predicted N-glycosylation sites. This agrees with our mass spectrometric analysis detecting two with the predicted glycopeptides in unglycosylated kind (Fig. 3D). ARSK was purified as a secreted enzyme, i.e. following passing intracellular top quality control. Arylsulfatase activity measured within this preparation was on account of recombinant ARSK due to the fact activity correlated with purified ARSK protein, as detected by mass fingerprint evaluation and quantified by Western blotting or Coomassie staining. In addition, activity was dependent on FGly modification of ARSK because the ARSK-C/A mutant, purified in parallel below identical situations, showed no significant activity. Kinetic evaluation of ARSK revealed a comparatively low affinity toward artificial arylsubstrates at the same time as a low distinct turnover of those pseudosubstrates. Equivalent enzymatic properties asJOURNAL OF BIOLOGICAL CHEMISTRYArylsulfatase K, a Novel Lysosomal SulfataseFIGURE 5. Subcellular localization of ARSK and binding to an MPR affinity column. A, HisTrap-purified ARSK (1 g) was loaded on a matrix with immobilized MPRs and incubated overnight. Soon after collecting the flow-through (FT), the column matrix was washed four times with binding PPARγ Inhibitor Synonyms buffer (BB) (fractions W1-W4) and 3 occasions with five mM glucose 6-phosphate (G6P) (fractions W5-W7). Bound ARSK was eluted with five mM M6P in ten fractions (E1-E10). All fractions have been analyzed by Western blotting using the anti-RGS-His6 antibody (upper panel). The reduced panel shows the outcomes obtained for the established lysosomal protein Scpep1, purified also by way of its RGS-His6-tag, which was subjected for the same MPR affinity chromatography protocol. B, ARSK, enriched by HisTrap chromatography (Fig. 3A), also as purified recombinant mouse Scpep1 (one hundred ng) (26) and purified recombinant FGE (40 ng) (24), both developed by HT1080 cells, had been analyzed by Western blotting working with the scFv M6P single-chain antibody fragment (upper panel) plus the anti-RGS-His6 antibody.", "domain": "chemistry", "round": 3} +{"url": "http://www.millipore.com/pathways/pathviewer.do?pathwayId=152", "date": "2014-04-18T23:15:50Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2014-15/segments/1397609535535.6/warc/CC-MAIN-20140416005215-00184-ip-10-147-4-33.ec2.internal.warc.gz", "language_score": 0.7783902883529663, "token_count": 889, "dump": "CC-MAIN-2014-15", "global_id": "webtext-fineweb__CC-MAIN-2014-15__0__1933004", "lang": "en", "text": "Development VEGF signaling and activation\nVEGF signaling and activation The vascular endothelial growth factor (VEGF) family of ligands and receptors iscrucial for vascular development and neovascularization in physiological and pathologicalprocesses in both embryo and adult . VEGFs denote a family of homodimericglycoproteins that currently consists of five members: VEGF-A, -B, -C, -D, and placentagrowth factor PLGF. VEGFR-2 is a high-affinity receptor for VEGF-A . Theactivated VEGFR-2 binds Phospholipase C gamma 1 ( PLC-gamma 1 ) That leadsto the phosphorylation and activation of this protein and results in hydrolysis of themembrane Phosphatidylinositol (4,5)-bisphosphate ( PtdIns(4,5)P2 ) and generationof the second messengers 1,2-diacylglycerol ( DAG ) and inositol(1,4,5)-trisphosphate ( IP3 ). DAG is a physiological activator of Proteinkinase C beta 1 ( PKC-beta ), whereas IP3 binds to a specific receptorpresent on the endoplasmic reticulum, resulting in the release of intracellular storedCa(2+) . PKC-beta phosphorylates and activates V-raf-1 murine leukemia viral oncogenehomolog 1 ( c-Raf-1 ) triggering Mitogen-activated protein kinase kinase 1 (MEK1 (MAP2K1) )/ Mitogen-activated protein kinase kinase 2( MEK2 (MAP2K2))/ Mitogen-activated protein kinase 3/1 ( Erk (MAPK1/3) ) signaling cascade.Erk ( MAPK1/3) can also be activated through PKC/ Sphingosinekinase 1 ( SPK1 ) pathway . SPK1 is an enzyme whichcatalyses Spingosine 1 phosphate formation from Sphingosine.Decrease of sphingosine concentration and increase of sphingosine1-phosphate leads to activation of V-Ha-ras Harvey rat sarcoma viral oncogenehomolog ( H-Ras ), apparently through inhibition of Neurofibromin and RASp21 protein activator 1 ( p120GAP ). H-Ras in turn binds to and activatesc-Raf-1 leading to Erk (MAPK1/3) activation. Activated Erk(MAPK1/3) activates by phosphorylation Jun oncogene( c-Jun ). The latter oneforms a complex with V-fos FBJ murine osteosarcoma viral oncogene homolog ( c-Fos) protein leading to DNA synthesis and cell proliferation . DAG is also a physiological activator of PKC-alpha which can signalthrough Conserved helix-loop-helix ubiquitous kinase ( IKK-alpha ) and Inhibitorof kappa light polypeptide gene enhancer in B-cells kinase beta ( IKK-beta ) toI-kB/ NF-kB pathway. , . NF-kBactivates transcription of Intercellular adhesion molecule 1 ( ICAM1 ), Vascularcell adhesion molecule 1 ( VCAM1 ) and E-selectin . VEGFR-2 also binds and activates Phosphoinositide-3-kinase regulatory subunit (PI3K reg class IA ) followed by the activation of catalyticsubunits of PI3K - PI3K cat class IA, which, in turn, results in an increase inlipid Phosphatidylinositol (3,4,5) ( PtdIns(3,4,5)P3 ) and activation of V-aktmurine thymoma viral oncogene homolog 1 AKT(PKB). The AKT(PKB) signalingpathway regulates cellular survival by inhibiting pro-apoptotic pathways . Brca1 represses the activity of VEGF-A via ESR1 and SP1and SP3 , .", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/mnk1-antibody-ab79365.html", "date": "2020-09-24T07:55:45Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-40/segments/1600400214347.17/warc/CC-MAIN-20200924065412-20200924095412-00002.warc.gz", "language_score": 0.7596983313560486, "token_count": 599, "dump": "CC-MAIN-2020-40", "global_id": "webtext-fineweb__CC-MAIN-2020-40__0__52384528", "lang": "en", "text": "Key features and details\n- Rabbit polyclonal to MNK1\n- Suitable for: WB\n- Reacts with: Mouse, Human\n- Isotype: IgG\nProduct nameAnti-MNK1 antibody\nSee all MNK1 primary antibodies\nDescriptionRabbit polyclonal to MNK1\nTested applicationsSuitable for: WBmore details\nSpecies reactivityReacts with: Mouse, Human\nPredicted to work with: Rat\nSynthetic non-phosphopeptide derived from human MNK1 around the phosphorylation site of threonine 255 (L-T-TP-P-C).\nStorage instructionsShipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.\nStorage bufferpH: 7.40\nPreservative: 0.02% Sodium azide\nConstituents: PBS, 50% Glycerol, 0.87% Sodium chloride\nWithout Mg2+ and Ca2+\nConcentration information loading...\nPurityImmunogen affinity purified\nOur Abpromise guarantee covers the use of ab79365 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\n|WB||1/500 - 1/1000. Detects a band of approximately 51 kDa (predicted molecular weight: 51 kDa).|\nFunctionMay play a role in the response to environmental stress and cytokines. Appears to regulate transcription by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap.\nSequence similaritiesBelongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.\nContains 1 protein kinase domain.\nmodificationsDual phosphorylation of Thr-250 and Thr-255 activates the kinase. Phosphorylation of Thr-385 activates the kinase.\nCellular localizationCytoplasm and Cytoplasm. Nucleus.\n- Information by UniProt\n- MAP kinase interacting kinase 1 antibody\n- MAP kinase interacting serine/threonine kinase 1 antibody\n- MAP kinase signal integrating kinase 1 antibody\nAll lanes : Anti-MNK1 antibody (ab79365) at 1/500 dilution\nLane 1 : 3T3 cell extracts\nLane 2 : 3T3 cell extracts with immunising peptide at 10 µg\nLysates/proteins at 30 µg per lane.\nPredicted band size: 51 kDa\nObserved band size: 51 kDa\nAdditional bands at: 27 kDa. We are unsure as to the identity of these extra bands.\nab79365 has not yet been referenced specifically in any publications.", "domain": "chemistry", "round": 3} +{"url": "https://www.research-collection.ethz.ch/handle/20.500.11850/301917", "date": "2023-12-08T23:12:23Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100779.51/warc/CC-MAIN-20231208212357-20231209002357-00711.warc.gz", "language_score": 0.8066025972366333, "token_count": 352, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__214040873", "lang": "en", "text": "Non-hydrolyzable Diubiquitin Probes Reveal Linkage-Specific Reactivity of Deubiquitylating Enzymes Mediated by S2 Pockets\n- Journal Article\nRights / licenseCreative Commons Attribution 4.0 International\nUbiquitin chains are important post-translational modifications that control a large number of cellular processes. Chains can be formed via different linkages, which determines the type of signal they convey. Deubiquitylating enzymes (DUBs) regulate ubiquitylation status by trimming or removing chains from attached proteins. DUBs can contain several ubiquitin-binding pockets, which confer specificity toward differently linked chains. Most tools for monitoring DUB specificity target binding pockets on opposing sides of the active site; however, some DUBs contain additional pockets. Therefore, reagents targeting additional pockets are essential to fully understand linkage specificity. We report the development of active site-directed probes and fluorogenic substrates, based on non-hydrolyzable diubiquitin, that are equipped with a C-terminal warhead or a fluorogenic activity reporter moiety. We demonstrate that various DUBs in lysates display differential reactivity toward differently linked diubiquitin probes, as exemplified by the proteasome-associated DUB USP14. In addition, OTUD2 and OTUD3 show remarkable linkage-specific reactivity with our diubiquitin-based reagents. Show more\nJournal / seriesCell Chemical Biology\nPages / Article No.\nOrganisational unit03412 - Glockshuber, Rudolf / Glockshuber, Rudolf\nMoreShow all metadata", "domain": "chemistry", "round": 3} +{"url": "https://cam2.com/product/cam2-full-synthetic-cvt-transmission-fluid/", "date": "2024-03-02T16:06:23Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707947475833.51/warc/CC-MAIN-20240302152131-20240302182131-00145.warc.gz", "language_score": 0.8878225088119507, "token_count": 270, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__134084118", "lang": "en", "text": "CAM2 FULL SYNTHETIC CVT TRANSMISSION FLUID\nCAM2 SYNTHETIC CVT FLUID is a full synthetic transmission fluid specifically designed to provide outstanding performance in North American Vehicles equipped with ether chain or push belt Continuously Variable Transmissions. This fluid is suitable for use as a service fill fluid for all CVT’s coupled with engine displacement sizes of greater than 2 Liters. CVT transmissions are very complex and unique transmissions in terms of the materials used in their construction and their operational characteristics. Therefore, to avoid or minimize the likelihood of catastrophic damage and costly repairs, these unique transmissions require fluids specifically designed for their complex and unique needs. CAM2 SYNTHETIC CVT FLUID is such a fluid and was developed in conjunction with one of the world’s leading additive technology leaders to provide smooth shifting and performance life for all CVT transmissions used in North American vehicles with engines sizes less than 3.5 liters.\nCAM2 Full Synthetic 12/1 Quart CVT Transmission Fluid, CAM2 Full Synthetic 5 Gallon CVT Transmission Fluid, CAM2 Full Synthetic 6 Gallon CVT Transmission Fluid, CAM2 Full Synthetic 55 Gallon CVT Transmission Fluid, CAM2 Full Synthetic Bulk CVT Transmission Fluid", "domain": "chemistry", "round": 3} +{"url": "https://www.semanticscholar.org/paper/Neural-control-of-distal-tubular-bicarbonate-and-f-Wang-Chan/5253bac0a6d9107daf8cc0d8c1e42559c1cb08be", "date": "2017-12-14T21:15:55Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-51/segments/1512948550986.47/warc/CC-MAIN-20171214202730-20171214222730-00206.warc.gz", "language_score": 0.9490556120872498, "token_count": 336, "dump": "CC-MAIN-2017-51", "global_id": "webtext-fineweb__CC-MAIN-2017-51__0__77341062", "lang": "en", "text": "Although previous studies have shown that inhibition of proximal tubular reabsorption of bicarbonate and fluid partially accounts for bicarbonaturia and diuresis observed in the denervated kidney, the role of the distal convoluted tubule in the neural regulation of electrolyte excretion has not been defined. This study was designed to examine the effects of denervation on bicarbonate and fluid reabsorption in the distal convoluted tubules by using in situ microperfusion methods. Early distal tubules were perfused with a solution containing 15 mM bicarbonate at a rate of 12 nl/min, and fluid samples were collected from the late distal tubule. Bicarbonate concentrations were measured as total CO2 by microcalorimetry. The rate of fluid absorption (Jv) was determined using [methoxy-3H]inulin as a volume marker. Before denervation, the rate of bicarbonate absorption (JHCO3-) was 24.7 +/- 2.6 peq.min-1.mm-1, and Jv was 1.80 +/- 0.14 nl.min-1.mm-1. After denervation, marked reductions in JHCO3- (51%) and Jv (60%) were observed. In contrast, sham denervation did not affect JHCO3- or Jv significantly. Our results indicate that the distal convoluted tubule can reabsorb bicarbonate and fluid under physiological conditions. We conclude that the transport processes in this segment of the nephron are regulated by renal nerve activity.", "domain": "chemistry", "round": 3} +{"url": "http://www.abcam.com/ab124707.html?productWallTab=Abreviews", "date": "2013-05-20T12:08:45Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2013-20/segments/1368698924319/warc/CC-MAIN-20130516100844-00065-ip-10-60-113-184.ec2.internal.warc.gz", "language_score": 0.7060073614120483, "token_count": 720, "dump": "CC-MAIN-2013-20", "global_id": "webtext-fineweb__CC-MAIN-2013-20__0__207296065", "lang": "en", "text": "Anti-DBF4 antibody [EPR5635] (ab124707)\n- Product nameAnti-DBF4 antibody [EPR5635]See all DBF4 primary antibodies ...\n- DescriptionRabbit monoclonal [EPR5635] to DBF4\n- Tested applicationsWB more details\n- Species reactivityReacts with: Human\nDoes not react withMouse, Rat\nSynthetic peptide corresponding to residues in Human DBF4 protein (Q9UBU7).\n- Positive controlPC-3, Jurkat, SW480, and HepG2 cell lysates.\n- General notesProduced under U.S. Patent No. 5,675,063.\n- Storage instructionsStore at -20°C. Stable for 12 months at -20°C\n- Dissociation constant (Kd) Kd = 2.49 x 10-10 M\n- Storage bufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%\n- PurityTissue culture supernatant\n- Clonality Monoclonal\n- Clone numberEPR5635\n- Research Areas\nOur Abpromise guarantee covers the use of ab124707 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\n|WB||WB: 1/10000 - 1/50000. Predicted molecular weight: 77 kDa.|\n- FunctionRegulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S phase. The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' and then is involved in regulating the initiation of DNA replication during cell cycle.\n- Tissue specificityHighly expressed in testis and thymus. Expressed also in most cancer cells lines.\n- Sequence similaritiesContains 2 BRCT domains.\nContains 1 DBF4-type zinc finger.\nmodificationsPhosphorylated upon DNA damage, probably by ATM or ATR.\n- Cellular localizationNucleus.\n- Activator of S phase kinase antibodyASK antibodyChiffon homolog A antibody\n- DBF4 antibodyDBF4 type zinc finger containing protein 1 antibodyDBF4-type zinc finger-containing protein 1 antibodyDBF4A antibodyDBF4A_HUMAN antibodyProtein DBF4 homolog A antibodyZDBF1 antibody\nAnti-DBF4 antibody [EPR5635] images\nAll lanes : Anti-DBF4 antibody [EPR5635] (ab124707) at 1/10000 dilution\nLane 1 : PC-3 cell lysates\nLane 2 : Jurkat cell lysates\nLane 3 : SW480 cell lysates\nLane 4 : HepG2 cell lysates\nLysates/proteins at 10 µg per lane.\nPredicted band size : 77 kDa\nEquilibrium disassociation constant (KD)\nLearn more about KD\nClick here to learn more about KD\nReferences for Anti-DBF4 antibody [EPR5635] (ab124707)\nab124707 has not yet been referenced specifically in any publications.", "domain": "chemistry", "round": 3} +{"url": "https://investigadores.uandes.cl/en/publications/characterization-of-proteolytic-activities-during-intestinal-rege-4", "date": "2024-03-02T19:27:19Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707947475897.53/warc/CC-MAIN-20240302184020-20240302214020-00344.warc.gz", "language_score": 0.8940578103065491, "token_count": 291, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__138695436", "lang": "en", "text": "Proteolysis carried out by different proteases control cellular processes during development and regeneration. Here we investigated the function of the proteasome and other proteases in the process of intestinal regeneration using as a model the sea cucumber Holothuria glaberrima. This echinoderm possesses the ability to regenerate its viscera after a process of evisceration. Enzymatic activity assays showed that intestinal extracts at different stages of regeneration possessed chymotrypsin-like activity. This activity was inhibited by i) MG132, a reversible inhibitor of chymotrypsin and peptidylglutamyl peptidase hydrolase (PGPH) activities of the proteasome, ii) E64d, a permeable inhibitor of cysteine proteases and iii) TPCK, a serine chymotrypsin inhibitor, but not by epoxomicin, an irreversible and potent inhibitor of all enzymatic activities of the proteasome. To elucidate the role which these proteases might play during intestinal regeneration, we carried out in vivo experiments injecting MG132, E64d and TPCK into regenerating animals. The results showed effects on the size of the regenerating intestine, cell proliferation and collagen degradation. These findings suggest that proteolysis by several proteases is important in the regulation of intestinal regeneration in H. glaberrima.", "domain": "chemistry", "round": 3} +{"url": "https://link.springer.com/chapter/10.1007%2F978-3-030-01572-5_12", "date": "2020-07-14T03:38:46Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-29/segments/1593657147917.99/warc/CC-MAIN-20200714020904-20200714050904-00346.warc.gz", "language_score": 0.8764390349388123, "token_count": 444, "dump": "CC-MAIN-2020-29", "global_id": "webtext-fineweb__CC-MAIN-2020-29__0__202713299", "lang": "en", "text": "Potentiometric Salinity Mapping of Mishrif Oilfield Waters in (Iraq’s) Southern Oil Fields\n- 116 Downloads\nThe hydrochemistry in the Mishrif reservoir, located at the main productive oilfields at Basrah, southern Iraq, is discussed. Water chemistry coupled with boron isotopes (10B, 11B) were analyzed using ICP-MS and ICP-SFMS, respectively, and used to determine the subsurface fluid flow direction in the oil traps and interpret the rock-fluid interaction. The presence of boron in brine waters is useful in identifying the sources of water intrusive to oil wells. The δ11B ranged between 33.7 and 35.9‰ with an average of 35.4‰ in the studied oilfields which is lower than that in the Dead Sea (39–57‰), indicating a dilution by the present seawater and injection water. The potentiometric subsurface maps were modelled and super-pressure sites that are of great importance in the oil exploration were marked to pay attention to during future drilling.\nKeywordsPotential mapping Boron isotopes Salinity Oilfield water\n- 1.Buchette, T.P.: Mishrif formation (Cenomanian-Turonian), southern Arabian Gulf: carbonate platform growth along a cratonic basin margin. In: Simo, J.A.T., Scott, R.W., Masse, J.P. (eds.) Cretaceous Carbonate Platforms. vol. 56, pp. 185–199. American Association of Petroleum Geologists Memoir (1993)Google Scholar\n- 2.Nader, F.H., De Boever, E., Gasparrini, M., Liberati, M., Dumont, C., Ceriani, A., Morad, S., Lerat, O., Doligez, B.: Quantification of diagenesis impact on the reservoir properties of the Jurassic Arab D and C members (Offshore, U.A.E.). Geofluids 13, 204–220 (2013)Google Scholar", "domain": "chemistry", "round": 3} +{"url": "https://etd.auburn.edu/handle/10415/7352", "date": "2024-04-15T21:53:22Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712296817033.56/warc/CC-MAIN-20240415205332-20240415235332-00783.warc.gz", "language_score": 0.9085772037506104, "token_count": 425, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__25146091", "lang": "en", "text": "Investigation of Multicomponent Transport Phenomena in Nafion 117 and Crosslinked Polyether-based Membranes via In Situ ATR FTIR Spectroscopy\nType of DegreePhD Dissertation\nMetadataShow full item record\nThis dissertation focuses on understanding transport and co-transport behavior for a series of species in dense, hydrated polymer membranes. The rate of solute transport through a membrane, permeability, is a fundamental property when selecting a membrane for an application of interest. However, it is challenging to characterize multicomponent transport using traditional techniques. This work investigates the transport of multiple components through polymeric membranes via a facile, in situ technique that combines the advantages of in situ characterization with spectroscopy; in situ ATR FTIR spectroscopy. Using this technique, the transport behavior of a series of alcohols and sodium acetate is investigated. The transport behavior of alcohols and their complex mixtures are probed as phenomena such as flux coupling and competitive sorption make prediction of multicomponent transport from single component data challenging, and is poorly understood. First, multicomponent transport in NafionTM 117, a commercially significant cation exchange membrane that has been researched extensively, is investigated for alcohols and complex mixtures of alcohols. Furthermore, a series of PEGDA membranes with varied fractional free volume and PEGDA-PEA-AMPS membranes of varied charge and hydrophobicity were synthesized and characterized for their permeability to methanol, sodium acetate, and their binary mixtures. Large deviations were observed between single component permeability and permselectivity compared to those extracted from multicomponent experiments, with variations of up to a factor of 11, demonstrating the importance of this characterization and technique for investigating membrane transport behavior. Overall, while much remains to be learned in this field, the fundamental understanding gained herein advances our understanding of the role of co-solutes, and membrane characteristics on transport behavior.", "domain": "chemistry", "round": 3} +{"url": "http://elimelechlab.yale.edu/people/amanda-n-quay", "date": "2017-09-23T23:27:31Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-39/segments/1505818689806.55/warc/CC-MAIN-20170923231842-20170924011842-00448.warc.gz", "language_score": 0.8231122493743896, "token_count": 969, "dump": "CC-MAIN-2017-39", "global_id": "webtext-fineweb__CC-MAIN-2017-39__0__74735142", "lang": "en", "text": "Amanda N. Quay\nPh.D. Student, Chemical and Environmental Engineering, Yale University\nB.S. in Chemical Engineering with Honors, Stanford University, 2016\nAmanda is a first year in Prof. Menachem Elimelech’s lab in the Chemical and Environmental Engineering department at Yale University. She received a B.S.H. in Chemical Engineering and a Minor in Environmental Engineering at Stanford University. While at Stanford, Amanda spent three years in Prof. William Mitch’s lab in the Civil and Environmental Engineering department. Her undergraduate thesis focused on understanding membrane fouling when wastewater is subjected to pretreatments, for applications in wastewater recycling.\nNow at Yale, Amanda looks forward to expanding her understanding of membrane processes and their applications. She hopes to apply this work to improve water quality and availability in very arid regions. Her current special investigation involves understanding modified membrane performance when subjected to both scalants and foulants.\nOutside of the lab, Amanda enjoys rock climbing, backpacking, and drinking lots of coffee.\npdfs and supporting information for group publications available on the main publications page.\n- “Ozone Promotion of Chloropicrin Formation by Amine Oxidation to Nitro Compounds.” D.L. McCurry, A.N. Quay, and W.A. Mitch. Environmental Science & Technology 50, 3 (2016).\n- “Thermochemical investigations of solute transfer into ionic liquid solvents: updated Abraham model equation coefficients for solute activity coefficient and partition coefficient predictions.” T.W. Stephens, A.N. Quay, C. Shen, N. Dabadge, A. Tian, M. Loera, B. Willis, A. Wilson, W.A. Acree, P. Twu, and J.L. Anderson. Physics and Chemistry of Liquids: An International Journal (2014).\n- “Correlation of Solute Transfer Into Toluene and Ethylbenzene from Water and from the Gas Phase Based on the Abraham Model.” T.W. Stephens, M. Loera, A.N. Quay, V. Chou, C. Shen, A. Wilson, W.E. Acree, Jr. and M.H. Abraham, The Open Thermodynamics Journal. 104, 5 (2011).\n- “Correlation of solute transfer into alkane solvents from water and from the gas phase with updated Abraham model equations.” T.W. Stephens, A.N. Quay, V. Chou, M. Loera, C. Shen, A. Wilson, W.E. Acree, Jr., and M.H. Abraham, Global Journal of Physical Chemistry., 1,1 (2011).\n- “Abraham Model Correlations for Transfer of Neutral Molecules and Ions to Sulfolane,” T. W. Stephens, N. E. De La Rosa, M. Saifullah, S. Ye, V. Chou, A. N. Quay, W. E. Acree, Jr. and M. H. Abraham, Fluid Phase Equilibria. 309, 1 (2011).\n- “Abraham Model Correlations for Solute Partitioning into o-Xylene, m-Xylene and p-Xylene from Both Water and the Gas Phase,” T. W. Stephens, N. E. De La Rosa, M. Saifullah, S. Ye, V. Chou, A. N. Quay, W. E. Acree, Jr. and M. H. Abraham, Fluid Phase Equilibria., 308, 64 (2011).\n- “Enthalpy of Solvation Correlations for Organic Solutes and Gases Dissolved in 2-Propanol, 2-Butanol, 2-Methyl-1-Propanol and Ethanol, T. W. Stephens, N. E. De La Rosa, M. Saifullah, S. Ye, V. Chou, A. N. Quay, W. E. Acree, Jr. and M. H. Abraham, Thermochemica. Acta. 523, 1 (2011).\n- “Enthalpy of Solvation Correlations for Organic Solutes and Gases Dissolved in 1-Propanol and Tetrahydrofuran,” T. W. Stephens, V. Chou, A. N. Quay, W. E. Acree, Jr. and M. H. Abraham, Thermochemica. Acta, 519, 103 (2011).", "domain": "chemistry", "round": 3} +{"url": "https://www.novonanmek.com/product", "date": "2022-10-04T09:53:06Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-40/segments/1664030337490.6/warc/CC-MAIN-20221004085909-20221004115909-00588.warc.gz", "language_score": 0.9594130516052246, "token_count": 282, "dump": "CC-MAIN-2022-40", "global_id": "webtext-fineweb__CC-MAIN-2022-40__0__217133866", "lang": "en", "text": "Fusion | Nature | Technology\nWe have created the Novoton by optimally packaging one or more of both technology and nature based carbon dioxide removals solutions into a one tonne of carbon removal unit.\nTech Based Removals\nNature Based Removals\nA Novoton is a tonne of carbon dioxide removed directly from the atmosphere, using one or more of both natural and technology based methods. Novotons lies somewhere between faster and expensive technology based solutions and slow & affordable nature based solutions depending on the percentage of technology based and nature based solution contained in it.\nGenerally technology based removals are faster. So, a Novoton that has a higher technology based removal component, retires early while a Novoton that has higher nature based component takes more time to retire as nature based removals are time consuming.\nSince a Novoton is a tonne of carbon dioxide removed directly from the atmosphere by one or more technological and natural methods, its retirement time lies somewhere between retirement time of carbon dioxide removed by technological and natural means and hence a Novoton is characterized by its retirement time.\nLearn More about Novotons\nWe have 5 Novotons characterized by their retirement times - Novoton 25, Novoton 20, Novoton 15, Novoton 10, and Novoton 5. All Novotons retire at their stipulated time despite their number.", "domain": "chemistry", "round": 3} +{"url": "http://www.nutritionaloutlook.com/science/page/7/0", "date": "2018-04-20T05:15:23Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-17/segments/1524125937114.2/warc/CC-MAIN-20180420042340-20180420062340-00557.warc.gz", "language_score": 0.9327077269554138, "token_count": 337, "dump": "CC-MAIN-2018-17", "global_id": "webtext-fineweb__CC-MAIN-2018-17__0__102265525", "lang": "en", "text": "Ingredients for better sleep, relaxation, and improved mood are backed by promising science.\nProtein is a highly popular supplement in both consumer and industry circles. But how much do industry insiders and consumers actually know about protein? And how much of what they think they know is, quite simply, wrong?\nResearch updates on methylsulfonylmethane.\nThe study findings demonstrate capsaicinoids’ potential for managing weight.\nAlgae Multi-Mineral Ingredient More Effective than Calcium Carbonate in Slowing Bone Loss in Animal Model of Osteoporosis\nIn the animal study, researchers sought to establish the extent to which Aquamin, a calcium-rich, algae-based multi-mineral complex ingredient, might outperform other calcium carbonate–based calcium supplements commonly used to help prevent osteopenia and osteoporosis.\nThe study established that, not only does the combination of Compound Solutions’ TeaCrine theacrine and caffeine enhance theacrine’s potency, it is also safe, with heart rate and blood pressure unaffected by co-administration.\nThe prospective study, which included 135,335 participants, found that excessive consumption of carbohydrates is a contributing factor to total mortality.\nThe detox category’s had its ups and downs, enjoying wild popularity and bullish sales, even as it comes in for criticism from the medical community and others.\nRecent stability tests evaluated ProDura’s ability to survive different pH and storage conditions for beverage products.\nThe study found that, in addition to increasing appetite control, Advantra Z also increased subjects’ energy levels.", "domain": "chemistry", "round": 3} +{"url": "http://www.jneurosci.org/content/12/1/222", "date": "2017-03-26T07:18:00Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-13/segments/1490218189130.57/warc/CC-MAIN-20170322212949-00468-ip-10-233-31-227.ec2.internal.warc.gz", "language_score": 0.9305343627929688, "token_count": 333, "dump": "CC-MAIN-2017-13", "global_id": "webtext-fineweb__CC-MAIN-2017-13__0__123444159", "lang": "en", "text": "An important step in the posttranslational modification of many bioactive neuropeptides, the carboxy-terminal amidation of glycine- extended peptides, is catalyzed by peptidylglycine alpha-amidating monooxygenase (PAM; EC 22.214.171.124). The expression of the gene encoding this enzyme was examined in adult rat brain by in situ hybridization histochemistry and immunocytochemistry. PAM mRNA transcripts and PAM- like immunoreactivity were detected in all major brain areas with the exception of the cerebellum. Very high levels of PAM mRNAs were found in the hypothalamic magnocellular neurons, the hippocampal formation, and olfactory cortex. These areas also showed strong PAM-like immunoreactivity. Regions known to contain high levels of amidated neuropeptides also expressed high levels of PAM mRNA. The observed heterogeneous PAM mRNA levels may reflect differences in the peptidergic activity of different neuronal systems. Interestingly, all pyramidal neurons of the hippocampus expressed very high levels of PAM mRNA, although no identified amidated peptide matches this distribution completely. Furthermore, PAM was not expressed exclusively in neuronal tissue but was also present in non-neuronal tissue. PAM transcripts could be localized in certain ventricular ependymal cells, with the highest expression in the lateral ventricle. Localization of PAM to non- neuronal cells and neurons not known to produce alpha-amidated peptides suggests that these cells may be producing as yet unidentified amidated neuropeptides.", "domain": "chemistry", "round": 3} +{"url": "http://pdgf-bb.com/best-products-list/487-biomatik/704-human-pdgf-bb-platelet-derived-growth-factor-bb-elisa-kit", "date": "2022-12-03T04:50:19Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-49/segments/1669446710924.83/warc/CC-MAIN-20221203043643-20221203073643-00122.warc.gz", "language_score": 0.7633436322212219, "token_count": 578, "dump": "CC-MAIN-2022-49", "global_id": "webtext-fineweb__CC-MAIN-2022-49__0__21927360", "lang": "en", "text": "Estimated Turnaround Time\n6-11 business days\nTarget's alterntive name\nPDGF-BB (Platelet Derived Growth Factor-BB)\nFor research use only. Not for diagnostic procedures.\nThe kit is manufactured at ISO 9001 certified facilities.\nSerum, plasma, tissue homogenates and other biological fluids\nELISA Enzyme-linked immunosorbent assays Code 90320007 SNOMED\nPrecaution of Use\nThe Stop Solution is acidic. Do not allow to contact skin or eyes.\nUse Human PDGF-BB (Platelet Derived Growth Factor-BB) ELISA Kit before 6 months\nE05 478 566 350 170 or Enzyme-Linked Immunosorbent Assays,E05 478 566 350 170 or Enzyme-Linked Immunosorbent Assays,Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.\nAplha, transcription related growth factors and stimulating factors or repressing nuclear factors are complex subunits of proteins involved in cell differentiation. Complex subunit associated factors are involved in hybridoma growth, Eosinohils, eritroid proliferation and derived from promotor binding stimulating subunits on the DNA binding complex. NFKB 105 subunit for example is a polypetide gene enhancer of genes in B cells.Platelets, also called thrombocytes or cloth cells in blood and are needed to stop bleeding by clumping and clotting the blood the vessels when the an injury occurs. Teh bone marrow will produce the platelets that have no nucleus. Platelates are unique to mammals, the are curved shaped 1900nm to 3100 nm large nucleus free clothing structures.", "domain": "chemistry", "round": 3} +{"url": "https://www.cellsignal.jp/products/primary-antibodies/phospho-mek1-thr292-antibody/51265", "date": "2020-02-21T17:32:14Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-10/segments/1581875145534.11/warc/CC-MAIN-20200221172509-20200221202509-00336.warc.gz", "language_score": 0.8510931730270386, "token_count": 639, "dump": "CC-MAIN-2020-10", "global_id": "webtext-fineweb__CC-MAIN-2020-10__0__116489581", "lang": "en", "text": "|26975||Phospho-MEK1 (Thr292) (D5L3K) Rabbit mAb||\n||H M R|\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.\nPhospho-MEK1 (Thr292) Antibody recognizes endogenous levels of MEK1 protein only when phosphorylated at Thr292. This antibody does not cross-react with MEK2 protein. This antibody cross-reacts with a 170 kDa protein of unknown identity in some cell lysates.Species predicted to react based on 100% sequence homology:\nPolyclonal antibodies are produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Thr292 of human MEK1 protein. Antibodies are purified by protein A and peptide affinity chromatography.\nMEK1 and MEK2, also called MAPK or Erk kinases, are dual-specificity protein kinases that function in a mitogen activated protein kinase cascade controlling cell growth and differentiation (1-3). Activation of MEK1 and MEK2 occurs through phosphorylation of two serine residues at positions 217 and 221, located in the activation loop of subdomain VIII, by Raf-like molecules. MEK1/2 is activated by a wide variety of growth factors and cytokines and also by membrane depolarization and calcium influx (1-4). Constitutively active forms of MEK1/2 are sufficient for the transformation of NIH/3T3 cells or the differentiation of PC-12 cells (4). MEK activates p44 and p42 MAP kinase by phosphorylating both threonine and tyrosine residues at sites located within the activation loop of kinase subdomain VIII.\nIn response to integrin signaling, p21-activated kinase -1 (PAK-1) phosphorylates MEK1 at Ser298, which enhances MEK1-ERK2 complex formation and MEK1 activation by Raf-1. These events positively regulate the Raf-1-MEK-ERK signaling cascade (5-9). Research studies have identified a negative regulatory loop in the Raf-1-MEK-ERK signaling cascade, in which ERK2-dependent phosphorylation of MEK1 at Thr292 negatively regulates MEK1 activation following cell adhesion. Specifically, ERK2-dependent phosphorylation of MEK1 also attenuates its PAK-1-mediated phosphorylation, contributing to a reduction in Raf-dependent phosphorylation of residues within the MEK1 activation loop (7,10).\nExplore pathways + proteins related to this product.\nCell Signaling Technology is a trademark of Cell Signaling Technology, Inc.\nXP is a registered trademark of Cell Signaling Technology, Inc.\nTween is a registered trademark of ICI Americas, Inc.", "domain": "chemistry", "round": 3} +{"url": "http://www.astrolika.com/stones-crystals/feldspar.html", "date": "2017-04-28T08:17:29Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-17/segments/1492917122886.86/warc/CC-MAIN-20170423031202-00159-ip-10-145-167-34.ec2.internal.warc.gz", "language_score": 0.9386745691299438, "token_count": 373, "dump": "CC-MAIN-2017-17", "global_id": "webtext-fineweb__CC-MAIN-2017-17__0__40168127", "lang": "en", "text": "Properties - Feldspar crystallize from magma in both with intrusive and extrusive igneous rocks. It is also present in metamorphic and sedimentary types of rocks. Feldspar has been derived from a german word which means a rock that does not contains ore .It is made up of group forming tectosilicate minerals that almost covers 60% of the earth's crust. Feldspathic refers to the material which contains feldspar. Rock is almost formed of calcic plagioclase feldspar is known as anorthosite. Its hardness is 6 to 6.5 at moh's scale and its specific gravity leads from 2.55 to 2.76. The crystal system is monoclinic or either triclinic.\nMohs (Hardness) Scale : 6.0 - 6.5\nHealing properties - This stone helps us to find our eccentric and electrifying ways to accomplish our goals. It supports us in issues like self alertness and self worship. This is stone very ingenious and superior for astronomical voyage. It assists in finding omitted items. It aids in dealing of skin and muscular disarray. It is the birth stone for Aquarius. It persuades one to flow with relationships, situations. It gives the ethereal connections from us to our dear ones which are exceptionally good for maintaining the relationship forever. It is useful for all the chakras.\nSpecial properties and its uses - In earth science and archeology feldspar are used for argon-argon dating, optical dating and thermoluminesence dating. Feldspar is available in various types we can judge the crystals by the edges known as striations. Monoclinic feldspar has striations while triclinic feldspar doesn't.", "domain": "chemistry", "round": 3} +{"url": "https://www.omicsonline.org/blog/2015/04/24/10125-Comparison-of-FollicleStimulating-Hormone-Glycosylation-Microheterogenity-by-Quantitative-Negative-Mode-NanoElectrospray-Mass-Spectrometry-of-PeptideNGlycanaseReleased-Oligosaccharides.html", "date": "2020-02-17T18:54:03Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-10/segments/1581875143079.30/warc/CC-MAIN-20200217175826-20200217205826-00271.warc.gz", "language_score": 0.8032883405685425, "token_count": 253, "dump": "CC-MAIN-2020-10", "global_id": "webtext-fineweb__CC-MAIN-2020-10__0__168490878", "lang": "en", "text": "Human Follicle-Stimulating Hormone (FSH) is a heterodimeric member of the glycoprotein hormone subfamily of the cystine knot growth factor superfamily . FSH consists of a common subunit that it shares with three other glycoprotein hormones, Luteinizing Hormone (LH), Chorionic Gonadotropin (CG), and Thyroid- Stimulating Hormone (TSH). A non-covalently associated FSHβ subunit confers hormone specificity. Both subunits possess two potential N-glycosylation sites. While the FSHα subunit exhibits only microheterogeneity in its glycosylation, the FSHβ subunit exhibits both macro- and micro-heterogeneity.\nCitation: Bousfield GR, Butnev VY, White WK, Hall AS, Harvey DJ (2015) Comparison of Follicle-Stimulating Hormone Glycosylation Microheterogenity by Quantitative Negative Mode Nano-Electrospray Mass Spectrometry of Peptide-N-Glycanase-Released Oligosaccharides. J Glycomics Lipidomics 4:129.", "domain": "chemistry", "round": 3} +{"url": "https://experts.umn.edu/en/publications/complex-allosteric-modulation-of-cardiac-muscarinic-receptors-by-", "date": "2023-09-24T08:37:14Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233506623.27/warc/CC-MAIN-20230924055210-20230924085210-00372.warc.gz", "language_score": 0.890681803226471, "token_count": 526, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__130344502", "lang": "en", "text": "A large number of diverse pharmacological agents bind to a secondary domain on the muscarinic receptor, to influence allosterically the interaction of ligands at the primary binding site. Based on common structural features of these antagonists, we examined the interaction of protamine, an endogenous polycationic peptide, and of polyamines with muscarinic receptors in rat heart. Our results provide several lines of qualitative evidence that protamine allosterically modulates the conformation of muscarinic receptors, in a marked negatively cooperative manner. It decelerated the dissociation of N-[3H]methylscopolamine ([3H]NMS) initiated by atropine, in a concentration-dependent fashion. Inhibition by protamine of [3H]NMS binding at equilibrium showed a distinct plateau, which increased in magnitude at higher ligand concentrations. Scatchard analysis of saturation isotherms of [3H]NMS binding in the absence and presence of protamine indicated that protamine did not alter B(max) in a statistically significant fashion, although there was a trend of a concentration-dependent increase in this parameter. On the other hand, it caused a marked concentration- dependent decrease in the affinity of [3H]NMS, and this effect reached a ceiling limit. However, there were marked quantitative deviations of the interaction of protamine from a simple ternary allosteric model. Some of these discrepancies could be explained by the tendency of protamine to increase B(max). The allosteric actions of protamine demonstrated in kinetic and equilibrium experiments were selective for m1 and m2 muscarinic receptors, compared with m3, m4, and m5 receptors, as studied in Chinese hamster ovary cells transfected with the genes of the different muscarinic receptors. Arginine residues play an important role in the allosteric interaction of protamine, inasmuch as poly-L-arginine qualitatively mimicked the effects of protamine. In contrast, no effects of the polyamines spermine, spermidine, and putrescine were observed on [3H]NMS binding. This is the first report on the allosteric modulation of muscarinic receptors by an endogenous peptide.\n|Original language||English (US)|\n|Number of pages||11|\n|State||Published - 1992|", "domain": "chemistry", "round": 3} +{"url": "https://resistancewire.com/resistance-wire/wire/standard/N8", "date": "2023-09-25T02:35:03Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233506676.95/warc/CC-MAIN-20230925015430-20230925045430-00482.warc.gz", "language_score": 0.7917489409446716, "token_count": 584, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__4464643", "lang": "en", "text": "NOTE: If you are looking for a specific gauge not listed above, please Contact Us to inquire about current lead times.\n- Withstands temperatures up to 1200°C\n- Uses: Typical applications include flat irons, ironing machines, water heaters, plastic molding dies, soldering irons, metal sheathed tubular elements, cartridge elements, quartz tube heaters, etc. N8 has a low temperature coefficient of resistance and a low change in resistance during its service life that combine to assure faster heat-up times, more uniform operating temperatures, and a longer useful life. Its lack of reactivity with MgO refractories make it the most suitable alloy for enclosed heating elements, especially those operating in the higher temperature ranges. The oldest and most common electric heating alloy, N8 is long established as the world standard of quality among all metallic heating element materials. Its excellent mechanical stability minimizes variables in element design, assures even stretch in coiled form, and eliminates problems of shrinkage, growth, sag, or distortion in use.\n- Common Name: Chromel A, Nikrothal 80, N8, Nichrome V, HAI-NiCr 80, Tophet A, Resistohm 80, Cronix 80, Protoloy, Nikrothal 8, Alloy A, MWS-650, Stablohm 650\n- Specific Resistance: 650 ohms/cmf, 108 microohm/cm\n- Nom. Temp. Coeff. of Resistance (TCR): 0.000085 ohm/ohm/°C (0-100°C)\n- Density: 0.304 lb/cu. in.\n- Specific Heat (20°C): 0.109869 cal/g\n- Nominal Coefficient of Linear Expansion: 14.5 X 10-6 in/in/°C\n- Approx. Melting Point: 1400°C\n- Tensile Strength at 20°C: 200 KPSI Hard, 100 KPSI Annealed\n- Magnetic Attraction: None", "domain": "chemistry", "round": 3} +{"url": "https://dspace.vutbr.cz/handle/11012/196429?locale-attribute=ru", "date": "2021-09-17T10:39:21Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-39/segments/1631780055632.65/warc/CC-MAIN-20210917090202-20210917120202-00007.warc.gz", "language_score": 0.8792828321456909, "token_count": 257, "dump": "CC-MAIN-2021-39", "global_id": "webtext-fineweb__CC-MAIN-2021-39__0__258314499", "lang": "en", "text": "Performance of Selected Polyurethane Joint Sealants in Concrete Structures\nMetadataПоказать полную информацию\nOften underestimated and neglected, joint sealants in concrete structures play an important role in protecting the structure against its premature deterioration. The focus of the presented paper lays upon the issue of sealing of joints in concrete structures. Concrete is one of the most difficult materials to seal since there are always small particles of dust and the material itself. In this paper, the joint will be viewed as traditional expansion joint. Two representatives of flexible one component polyurethane sealants were selected. The main reason for this selection was that conventional repair materials are usually very rigid and easily incline towards the formation of cracks and gaps. The aim of this paper is not only to verify the suitability of selected materials but also to demonstrate that polyurethane sealants might be a better and long-lasting solution for filling of joints and patching of cracks within concrete structures.\nDocument typePeer reviewed\nDocument versionFinal PDF\nSourceMATEC Web of Conferences. 2018, vol. 146, issue 1, p. 1-6.", "domain": "chemistry", "round": 3} +{"url": "https://pulse.ncpolicywatch.org/2019/11/12/drinking-water-wells-in-central-nc-including-wake-and-mecklenburg-counties-at-increased-risk-of-containing-cancer-causing-contaminant/", "date": "2022-07-01T18:06:17Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-27/segments/1656103943339.53/warc/CC-MAIN-20220701155803-20220701185803-00184.warc.gz", "language_score": 0.9483561515808105, "token_count": 649, "dump": "CC-MAIN-2022-27", "global_id": "webtext-fineweb__CC-MAIN-2022-27__0__286136493", "lang": "en", "text": "More than half of the drinking water wells in central North Carolina could contain levels of hexavalent chromium above the state’s health advisory level, according to a new study by Duke University professor and scientist Avner Vengosh.\nAnd wells in Wake and Mecklenburg counties are at heightened risk of containing the known carcinogen.\nAlthough hexavalent chromium — also known as Chromium 6 — is often found near coal ash ponds, it is also naturally occurring within certain geologic belts.\nOf 865 wells that Duke researchers tested, 470 exceeded 0.07 parts per billion for hexavalent chromium, the state’s drinking water advisory level. That level is based on a 1-in-1-million cancer risk over a 70-year lifetime. While not enforceable, the state’s benchmark is more stringent than the EPA’s, which is 100 ppb.\nResearchers then used this data to develop a computer model that predicted the occurrence of exceedances in drinking water wells based on the their location, including an area’s geology. The model also factored in the acidity, oxygen content, and salinity of the groundwater.\n“The areas where we see the largest number of groundwater users, like Wake and Mecklenburg Counties, coincide with some of the highest probabilities for the occurrence of hexavalent chromium above the health advisory level,” said Rachel Coyte, a doctoral student in Vengosh’s lab and lead author on the study.\nRoughly 4 million people in North Carolina rely on groundwater for drinking, cooking and bathing. Private drinking water wells are not regulated by the federal Safe Drinking Water Act. State law requires water from wells drilled within the last 10 years to be tested initially, but there is no requirement for subsequent monitoring. Older wells aren’t required to be tested at all.\n“Unlike public groundwater systems, private wells have no testing requirements and therefore many private well owners do not know the concentration of hexavalent chromium in their well water,” Vengosh said. “Since we show that total chromium can be a good proxy for the presence of hexavalent chromium, homeowners can test total chromium, which is more common and cheaper.”\nUnder-the-sink reverse osmosis systems can remove hexavalent chromium. They cost $150 to $200 per sink.\nSome well owners are hesitant to test their wells. Naeema Muhammad, co-director of the NC Environmental Justice Network, recently told an audience at UNC that some low-income households “don’t want to know” what’s in their water because they can’t afford treatment systems on their wells.\n“They’re afraid if they can’t treat their water, they’ll have to move” — impractical or even impossible for low-income people, Muhammad said.\nVengosh and Coyte’s findings were published in the journal Science of the Total Environment; the study was funded by a grant from the National Science Foundation.", "domain": "chemistry", "round": 3} +{"url": "http://www.lovelyskin.com/o/stimulash-fusion-grooming-enhancing-brow-duo", "date": "2016-10-26T21:14:37Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2016-44/segments/1476988720973.64/warc/CC-MAIN-20161020183840-00044-ip-10-171-6-4.ec2.internal.warc.gz", "language_score": 0.686815619468689, "token_count": 462, "dump": "CC-MAIN-2016-44", "global_id": "webtext-fineweb__CC-MAIN-2016-44__0__256405896", "lang": "en", "text": "Give your brows the TLC they deserve with a hardworking, high performance treatment that encourages shape, length and fullness. One side is supercharged with extra SymPeptides to enhance brows at night with an easy applicator brush, while the other side is a grooming gel that contains a lighter formula to keep you looking flawless during the day.\nFor optimal results, apply brow enhancing serum to eyebrows before bedtime. For perfectly groomed brows, use the grooming gel bristle applicator to shape and style brows, as desired. Allow gel formula to set and dry.\nEyebrow Enhancing Serum: WATER/AQUA/EAU, ALUMINUM STARCH OCTENYLSUCCINATE, GLYCERIN, POLYSORBATE 20, PVP, MYRISTOYL PENTAPEPTIDE-17, MYRISTOYL HEXAPEPTIDE-16, CAMELINA SATIVA SEED OIL, SORBITOL, DIMETHICONE, SODIUM CARBOMER, SODIUM ACRYLATE/ACRYLOYLDIMETHYL TAURATE COPOLYMER, ISOHEXADECANE, VEGETABLE OIL, ETHYLHEXYLGLYCERIN, POLYSORBATE 80, PHENOXYETHANOL, DISODIUM EDTA.\nEyebrow Grooming Gel: WATER/AQUA/EAU, GLYCERIN, POLYQUATERNIUM-68, GUAR HYDROXYPROPYLTRIMONIUM CHLORIDE, MYRISTOYL PENTAPEPTIDE-17, MYRISTOYL HEXAPEPTIDE-16, HYDROXYETHYLCELLULOSE, POLYSORBATE 20, ETHYLHEXYLGLYCERIN, PHENOXYETHANOL.\n|Mon-Thur||9 - 6 p.m. CT|\n|Fri||9 - 5 p.m. CT|\n|Sat||9 - 3 p.m. CT|\n|Sun / Holidays||Closed|", "domain": "chemistry", "round": 3} +{"url": "https://www.hindawi.com/journals/jnt/2012/167128/ref/", "date": "2017-03-23T04:19:44Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-13/segments/1490218186774.43/warc/CC-MAIN-20170322212946-00523-ip-10-233-31-227.ec2.internal.warc.gz", "language_score": 0.749872624874115, "token_count": 2681, "dump": "CC-MAIN-2017-13", "global_id": "webtext-fineweb__CC-MAIN-2017-13__0__166453755", "lang": "en", "text": "- About this Journal ·\n- Abstracting and Indexing ·\n- Aims and Scope ·\n- Annual Issues ·\n- Article Processing Charges ·\n- Articles in Press ·\n- Author Guidelines ·\n- Bibliographic Information ·\n- Citations to this Journal ·\n- Contact Information ·\n- Editorial Board ·\n- Editorial Workflow ·\n- Free eTOC Alerts ·\n- Publication Ethics ·\n- Reviewers Acknowledgment ·\n- Submit a Manuscript ·\n- Subscription Information ·\n- Table of Contents\nJournal of Nanotechnology\nVolume 2012 (2012), Article ID 167128, 6 pages\nHenna (Lawsonia inermis L.) Dye-Sensitized Nanocrystalline Titania Solar Cell\n1Department of Physics, College of Science, University of Bahrain, P.O. Box 32038, Bahrain\n2College of Graduate Studies and Research, Ahlia University, P.O. Box 10878, Bahrain\n3Department of Chemistry, University of Bahrain, P.O. Box 32038, Bahrain\nReceived 15 June 2011; Revised 21 October 2011; Accepted 24 October 2011\nAcademic Editor: Thomas Stergiopoulos\nCopyright © 2012 Khalil Ebrahim Jasim et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.\n- K. Hara and H. Arakawa, “Dye-sensitized solar cells,” in Handbook of Photovoltaic Science and Engineering, A. Luque and S. Hegedus, Eds., chapter 15, p. 663, John Wiley & Sons, 2003.\n- J. Zhao, A. Wang, and M. A. Green, “24.5% efficiency silicon PERT cells on MCZ substrates and 24.7% efficiency PERL cells on FZ substrates,” Progress in Photovoltaics, vol. 7, pp. 471–274, 1999.\n- M. I. Hoffert, K. Caldeira, A. K. Jain et al., “Energy implications of future stabilization of atmospheric CO2 content,” Nature, vol. 395, no. 6705, pp. 881–884, 1998.\n- B. O'Regan and M. Grätzel, “A low-cost, high-efficiency solar cell based on dye-sensitized colloidal TiO2 films,” Nature, vol. 353, no. 6346, pp. 737–740, 1991.\n- M. K. Nazerruddin, A. Kay, I. Ridicio, et al., “Conversion of light to electricity by cis-X2bis(2,2'-bipyridyl-4,4'-dicarboxylate)ruthenium(II) charge-transfer sensitizers (X = , , , , and ) on nanocrystalline TiO2 electrodes,” Journal of the American Chemical Society, vol. 115, pp. 6382–6390, 1993.\n- M. Law, L. E. Greene, J. C. Johnson, R. Saykally, and P. Yang, “Nanowire dye-sensitized solar cells,” Nature Materials, vol. 4, no. 6, pp. 455–459, 2005.\n- M. Yang, D. W. Thompson, and G. J. Meyer, “Dual sensitization pathways for TiO2 by Na2[Fe(bpy)(CN)4],” Inorganic Chemistry, vol. 39, no. 17, pp. 3738–3739, 2000.\n- G. M. Hasselmann and G. J. Meyer, “Sensitization of nanocrystalline TiO2 by Re(I) polypyridyl compounds,” The Journal of Physical Chemistry, vol. 212, no. 1, pp. 39–44, 1999.\n- A. Islam, K. Hara, L. P. Singh et al., “Dual electron injection from charge-transfer excited states of TiO2-anchored Ru(II)-4,4'-dicarboxy-2,2'-biquinoline complex,” Chemistry Letters, no. 5, pp. 490–491, 2000.\n- G. P. Smestad, “Education and solar conversion: demonstrating electron transfer,” Solar Energy Materials and Solar Cells, vol. 55, no. 1-2, pp. 157–178, 1998.\n- C. G. Garcia, A. S. Polo, and N. Y. Iha, “Fruit extracts and ruthenium polypyridinic dyes for sensitization of TiO2 in photoelectrochemical solar cells,” Journal of Photochemistry and Photobiology. A, vol. 160, no. 1-2, pp. 87–91, 2003.\n- Y. Amao and T. Komori, “Bio-photovoltaic conversion device using chlorine-e6 derived from chlorophyll from Spirulina adsorbed on a nanocrystalline TiO2 film electrode,” Biosensors and Bioelectronics, vol. 19, no. 8, pp. 843–847, 2004.\n- S. Yanagida, G. K. R. Senadeera, K. Nakamura, T. Kitamura, and Y. Wada, “Recent research progress of dye-sensitized solar cells in Japan,” Comptes Rendus Chimie, vol. 9, no. 5-6, pp. 597–604, 2006.\n- S. Hao, J. Wu, Y. Huang, and J. Lin, “Natural dyes as photosensitizers for dye-sensitized solar cell,” Solar Energy, vol. 80, no. 2, pp. 209–214, 2006.\n- A. S. Polo and N. Y. Iha, “Blue sensitizers for solar cells: natural dyes from Calafate and Jaboticaba,” Solar Energy Materials and Solar Cells, vol. 90, no. 13, pp. 1936–1944, 2006.\n- G. R. A. Kumara, S. Kaneko, M. Okuya, B. Onwona-Agyeman, A. Konno, and K. Tennakone, “Shiso leaf pigments for dye-sensitized solid-state solar cell,” Solar Energy Materials and Solar Cells, vol. 90, no. 9, pp. 1220–1226, 2006.\n- K. E. Jasim and A. M. Hassan, “Nanocrystalline TiO2 based natural dye sensitized solar cells,” International Journal of Nanomanufacturing, vol. 4, no. 1–4, pp. 242–247, 2009.\n- K. E. Jasim, S. Al-Dallal, and A. M. Hassan, “Natural dye-sensitised photovoltaic cell based on nanoporous TiO2,” International Journal of Nanoparticles, vol. 4, no. 4, pp. 359–368, 2011.\n- K. E. Jasim, “Dye sensitised solar cells—working principles, challenges and opportunities,” in Solar Cells/Book 2, INTECH, 2011.\n- K. Tennakone, G. Kumara, I. Kottegota, and K. Wijayantha, “The photostability of dye-sensitized solid state photovoltaic cells: factors determining the stability of the pigment in a nanoporous n-Tio2/cyanidin/p-CuI cell,” Semiconductor Science and Technology, vol. 12, no. 1, p. 128, 1997.\n- N. J. Cherepy, G. P. Smestad, M. Gratzel, and J. Z. Zhang, “Ultrafast electron injection: implications for a photoelectrochemical cell utilizing an anthocyanin dye-sensitized TiO2 nanocrystalline electrode,” Journal of Physical Chemistry B, vol. 101, no. 45, pp. 9342–9351, 1997.\n- H. E. Harding, E. T. Hoke, P. B. Armstrong et al., “Increased light harvesting in dye-sensitized solar cells with energy relay dyes,” Nature Photonics, vol. 3, no. 7, pp. 406–411, 2009.\n- S. Yanagida, “Recent research progress of dye-sensitized solar cells in Japan,” Comptes Rendus Chimie, vol. 9, no. 5-6, pp. 597–604, 2006.\n- K. Tennakone, V. P. S. Perera, I. R. M. Kottegoda, and G. R. R. A. Kumara, “Dye-sensitized solid state photovoltaic cell based on composite zinc oxide/tin (IV) oxide films,” Journal of Physics D, vol. 32, no. 4, pp. 374–379, 1999.\n- M. Matsumoto, Y. Wada, T. Kitamura et al., “Fabrication of solid-state dye-sensitized TiO2 solar cell using polymer electrolyte,” Bulletin of the Chemical Society of Japan, vol. 74, no. 2, pp. 387–393, 2001.\n- V. Noack, H. Weller, and A. Eychmüller, “Electron transport in particulate ZnO electrodes: a simple approach,” Journal of Physical Chemistry B, vol. 106, no. 34, pp. 8514–8523, 2002.\n- N. Kopidakis, K. D. Benkstein, J. van de Lagemaat, and A. J. Frank, “Transport-limited recombination of photocarriers in dye-sensitized nanocrystalline TiO2 solar cells,” Journal of Physical Chemistry B, vol. 107, no. 41, pp. 11307–11315, 2003.\n- J. H. Xiang, P. X. Zhu, Y. Masuda, M. Okuya, S. Kaneko, and K. Koumoto, “Flexible solar-cell from zinc oxide nanocrystalline sheets self-assembled by an in-situ electrodeposition process,” Journal of Nanoscience and Nanotechnology, vol. 6, no. 6, pp. 1797–1801, 2006.\n- I. Robel, B. A. Bunker, and P. V. Kamat, “Single-walled carbon nanotube-CdS nanocomposites as light-harvesting assemblies: photoinduced charge-transfer interactions,” Advanced Materials, vol. 17, no. 20, pp. 2458–2463, 2005.\n- T. Hasobe, S. Fukuzumi, and P. V. Kamat, “Organized assemblies of single wall carbon nanotubes and porphyrin for photochemical solar cells: charge injection from excited porphyrin into single-walled carbon nanotubes,” Journal of Physical Chemistry B, vol. 110, no. 50, pp. 25477–25484, 2006.\n- J. Krüger, R. Plass, M. Grätzel, P. J. Cameron, and L. M. Peter, “Charge transport and back reaction in solid-state dye-sensitized solar cells: a study using intensity-modulated photovoltage and photocurrent spectroscopy,” Journal of Physical Chemistry B, vol. 107, no. 31, pp. 7536–7539, 2003.\n- E. Stathatos, P. Lianos, A. S. Vuk, and B. Orel, “Optimization of a quasi-solid-state dye-sensitized photoelectrochemical solar cell employing a ureasil/sulfolane gel electrolyte,” Advanced Functional Materials, vol. 14, no. 1, pp. 45–48, 2004.", "domain": "chemistry", "round": 3} +{"url": "https://www.myripon.com/post/something-in-the-water-ripon-cancer-diagnoses-continue-to-rise-1", "date": "2022-07-05T03:11:57Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-27/segments/1656104512702.80/warc/CC-MAIN-20220705022909-20220705052909-00506.warc.gz", "language_score": 0.9721991419792175, "token_count": 1092, "dump": "CC-MAIN-2022-27", "global_id": "webtext-fineweb__CC-MAIN-2022-27__0__33778310", "lang": "en", "text": "Updated: Mar 8, 2020\nBy Joanna Metheny\nIn the past few weeks, most of Ripon’s residents have likely heard at least something about the apparent rise in cases of pediatric cancer surrounding\nMany long term residents will remember the decades-long running of a Nestle plant on Industrial Avenue here in town. They manufactured both caffeinated and decaffeinated instant coffee and tea from 1948 until the plant’s closure in 1994. Longer-term residents might also recall the water pollution scandal, as well as a cluster of possibly related cancer cases surrounding the plant’s operations, although both they and newer residents might not be aware of the details surrounding the situation.\nNestle used several solvents in order to decaffeinate coffee beans. From 1957 to 1970, the company used trichloroethylene or TCE for extraction, and from 1970 to 1986 (at which point they stopped decaffeinating beans), they used methylene chloride or MC. According to the Agency for Toxic Substances & Disease Registry, TCE can cause everything from dizziness and nausea, to headaches and death, and is a known human carcinogen. The ATSDR website states TCE “breaks down very slowly in soil and water and is removed mostly through evaporation to air” and “is expected to remain in groundwater for a long time since it is not able to evaporate”. In addition to a multitude of other serious health issues, TCE can in particular cause kidney and liver cancers.\nMethylene chloride is considered a likely carcinogen and is known to cause a range of health issues including liver dysfunction, respiratory and cardiovascular problems, headaches, irritability, and a decrease in the blood’s ability to carry oxygen. According to the ATSDR website “chronic exposure may be more serious for children because of their potential longer latency period”. It has also been found that MC can cross into the placenta, and has been detected in breastmilk.\nNestle stored the used solvents in above-ground storage tanks. In 1986, sixteen years after the discontinuation of its use, it was discovered that TCE had leached into two of Nestle’s on-site wells. For some reason, a filtration system was installed in only one of the wells, and later both wells, as well as a third were all destroyed, and a 4th was created to replace the factory’s water supply. At some point after this, an additional two wells were installed. It is speculated that the chemicals were found in the water supply either due to an accidental leak of the storage tank or due to a leak in the city’s sewer system, which channeled Nestle’s wastewater. The Cleanup and Abatement Order of 2006, states that the TCE plume “’ appears’ to be defined west, north, and east of the facility”, and then “it is uncertain how far the plume has migrated west” of the wells that were being monitored for contamination.\nIn 2002, Nestle gave Ripon a settlement of $1 million to be applied to filters and development of new wells. Since that time, Nestle, the City of Ripon, and the state have all partnered together to conduct ongoing testing for TCE (but the water is not regularly tested for MC). According to Ripon’s Director of Public Works, Ted Johnston, the Nestle cleanup effort is an ongoing process. Each of the city’s wells is tested every three years for TCE and other volatile chemicals, and if one of the readings is higher than the MCL, or Maximum Containment Level, then the well is monitored annually until the reading falls back below the MCL. Johnston shared that all of the wells in Ripon are interconnected and sourced from the same aquifers. Most recently, Well #3, which is located in the 2nd St. and Linda Ave. the area has been found to have contaminated water and is currently undergoing treatment. Prior contamination spots have included well #4, and an area near the water treatment plant. Each time contamination in a well is discovered, measures are taken to clear the water of VOCs, but due to the nature of underground aquifers, and TCE’s inability to dissipate unless exposed to air, the contamination continues to move. This factor, in addition to the fact that our municipal water sources are all interconnected, raises some concerns about residents’ exposure.\nA reading that falls below the Maximum Containment Level does not indicate there is zero traces of a chemical. As recently as 2008, in addition to TCE, both tetrachloroethylene, or PCE (a dry cleaning solvent), and dibromochloropropane, or DBCP (a pesticide used in agriculture), were detected in our water supply. If we know that the TCE cloud (and other chemicals) persists and migrates in our water supply to this day, residents had unmeasurable exposure to it through the water system prior to its discovery in 1986, and it is a known carcinogen, is it not reasonable to at least consider it as a cause of the current issues our residents are facing?", "domain": "chemistry", "round": 3} +{"url": "https://needarest.com/eight-myths-about-fabricadeportais-com/", "date": "2023-09-22T12:51:06Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233506399.24/warc/CC-MAIN-20230922102329-20230922132329-00305.warc.gz", "language_score": 0.8532258868217468, "token_count": 709, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__144234888", "lang": "en", "text": "Fabrica de Porais – Sites de Qualidade: A Revolutionary Approach to Fabricating Quality Ceramic Filters\nFabrica de Porais – Sites de Qualidade is a groundbreaking initiative focused on fabricating ceramic filters of superior quality. This article presents an overview of this innovative factory and its pioneering techniques in manufacturing ceramic filters.\nTitle: Fabrica de Porais – Sites de Qualidade: Revolutionizing Ceramic Filter Fabrication\nCeramic filters are integral components of many industrial processes, including water and wastewater treatment, oil and gas filtration, and air pollution control. The demand for ceramic filters has been steadily increasing due to their exceptional filtration efficiency and chemical stability. To meet this rising demand, the Fabrica de Porais – Sites de Qualidade was established as a state-of-the-art facility specializing in the production of top-notch ceramic filters.\n1. Raw Material Selection: The factory meticulously chooses high-quality raw materials for filter production. This selection includes superior-grade ceramic raw materials, such as alumina, zirconia, and silicon carbide, which offer excellent mechanical strength, thermal resistance, and chemical stability.\n2. Advanced Molding Techniques: The factory employs advanced molding techniques to obtain intricate shapes and high precision in filter design. These techniques include slip casting, extrusion, and dry pressing, ensuring consistency in filter dimensions and structure.\n3. Controlled Firing Process: The firing or sintering process is crucial to achieving excellent mechanical and chemical properties in ceramic filters. Fabrica de Porais – Sites de Qualidade implements controlled atmosphere firing techniques, maintaining precise temperature profiles and optimizing the sintering parameters. This meticulous control ensures minimal defects and high filter strength.\n4. Innovative Porosity Control: One of the key features of Fabrica de Porais – Sites de Qualidade filters is their customizable porosity. The factory utilizes innovative techniques to precisely control the pore size, distribution, and connectivity throughout the filter. This controlled porosity enhances filter performance, allowing efficient particle and liquid retention while minimizing the pressure drop across the filter.\nQuality Assurance Measures:\n1. Stringent Testing: Fabrica de Porais – Sites de Qualidade employs rigorous quality control measures throughout the production process. Comprehensive testing is performed on raw materials, fabricadeportais.com intermediate stages of manufacturing, and the final product, ensuring compliance with international standards.\n2. Performance Evaluation: The performance of ceramic filters is evaluated using advanced testing methods, including permeability, flow resistance, pressure drop, and particulate removal efficiency analysis. These evaluations guarantee that the filters meet the stringent requirements of various industrial applications.\n3. Traceability: The factory maintains a comprehensive traceability system to track the raw materials used in each filter. This ensures accountability and enables quick identification and rectification of any potential quality issues.\nFabrica de Porais – Sites de Qualidade has revolutionized the fabrication of ceramic filters through its commitment to producing high-quality products. The factory’s incorporation of advanced molding techniques, controlled firing processes, and innovative porosity control has resulted in filters that offer outstanding performance, durability, and reliability. With these cutting-edge techniques and stringent quality control measures, Fabrica de Porais – Sites de Qualidade continues to set new standards in ceramic filter manufacturing.", "domain": "chemistry", "round": 3} +{"url": "http://thefilelocker.com/pdf-uptake-of-tyramine-by-rat-hepatocytes-.html", "date": "2018-11-17T16:03:08Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-47/segments/1542039743714.57/warc/CC-MAIN-20181117144031-20181117165408-00057.warc.gz", "language_score": 0.8629475235939026, "token_count": 7196, "dump": "CC-MAIN-2018-47", "global_id": "webtext-fineweb__CC-MAIN-2018-47__0__73529867", "lang": "en", "text": "Biochimica et Biophysica Acta, 1176 (1993) 77-82 © 1993 Elsevier Science Publishers B.V. All rights reserved 0167-4889/93/$06.00\nUptake of tyramine by rat hepatocytes Zhi-Duan Zhong, Simone Wattiaux-De Coninck and Robert Wattiaux Laboratoire de Chimie Physiologique, Facultes Universitaires, Notre-Dame de la Paix, Namur (Belgium)\n(Received 30 July 1992)\nKey words: Tyramine; Transporter; Hepatocyte; (Rat)\nObservations on the uptake of tyramine by hepatocytes indicate that the amine is taken up by simple diffusion and a transporter mediated system, with a K m of 39 /~M and a Vmax of 270 pmol/min/105 cells. The carrier-mediated process is pH- and temperature-dependent and requires an activation energy of 12.9 kcal/mol. An overshoot uptake is achieved a few minutes after adding this amine to the cell suspension, suggesting that active transport is involved. This is supported by the finding that partial inhibition of the uptake can be induced by oligomycin, azide, cyanide and dinitrophenol. NO3, SCN- and SO4z , which change the membrane potential significantly, and depress the transporter mediated uptake further, suggesting that the membrane potential is the driving force for the entry of this amine across hepatic membrane. Cysteine is essential for the normal carrier function; whereas, histidine, tryptophan, arginine and lysine do not directly deal with the activity of the carrier. Many substances, but not amino acids, H, M, and N receptor agonists, can inhibit the uptake of tyramine. It is possible that other amines can enter hepatocytes by using this transporter.\nIntroduction Tyramine, a sympathomimetic amine is found in small amounts in chromaffin granules and sympathetic nervous tissues . Its physiological function is still unknown. An excess of tyramine in general circulation can induce peripheral vasoconstriction by causing a release of catecholamines from sympathetic nerve endings and adrenal medulla. Such a situation does not normally take place, although this amine is relatively abundant in some foods (cheese, chocolate) and is probably produced by bacterial degradation in the intestine. This suggests that tyramine could be quickly removed by the liver before it enters general circulation. However, in some circumstances, for example after intake of monoamine oxidase inhibitors and in certain nutritional conditions, the concentration of tyramine in blood may increase and cause a severe hypertensive crisis . Patients who suffer from mi-\nCorrespondence to: R. Wattiaux, Laboratoire de Chimie Physiologique, Facultes Universitaires Notre-Dame de la Paix, 61, rue de Bruxelles, B-5000 Namur, Belgium. Abbreviations: FCCP, carbonyl cyanide p-trifluoromethoxyphenylhydrazone; NEM, N-ethylmaleimide; pAPMA, p-aminophenylmercuric acetate; EMTSA, ethylmercurithiosalicyclic acid; PITC, phenylisothiocyanate; pCMB, p-chloromercuribenzoate; PMC, phenylmercuric chloride; pCMPS, p-chloromercuriphenylsulfonate; EAI, ethylacetimidate; TNBS, trinitrobensulfonic acid; PGO, phenylglyoxal; NBS, n-bromosuccinimide; DEP, diethylpyrocarbonate.\ngraine are generally advised not to eat cheese, since the tyramine it contains could induce a migraine attack [31. To our knowledge, detailed information concerning the uptake of tyramine by the liver is not available. In the work reported here, we have studied this uptake mainly by using isolated hepatocytes. Our results show that tyramine can be quickly taken up by hepatocytes, both by simple diffusion and a transporter-mediated process. Materials and Methods The experiments were performed on male Wistar rats, weighing about 200 g, that were starved for 20 h before killing. Hepatocytes were isolated according to the method of Seglen with slight modification: both Ca2+-free and collagenase perfusion were carried out at 34°C for 6 min. For all the experiments, only the preparations where more than 90% of the cells excluded Trypan blue were used. After isolation, the cells were kept at 4°C until being used. We used the cells no more than 2 h after being isolated. In that condition, the quality of the cells did not change. Unless stated in the legends of the figures, transport assays were performed in R P M I 1640 medium without serum, containing 10 m M H e p e s (pH 7.6), at 37°C. 15 s incubation time was chosen. In this case, the amounts of [14C]tyramine within the cells after incubation did not exceed 5% of the amount added to the medium. In\n78 brief, 3 • 105 cells were preincubated at 37°C for 2 min. They were then incubated with 6.6 tzM [~4C]tyramine (spec. act. 2.07 GBq/mmol) in a final volume of 200/xl in the absence or presence of inhibitors (which were added simultanously with the labelled tyramine, except for those indicated in the legends). The uptake reaction was stopped by the addition of 400 Izl ice-cold medium. Following this, 200-/21 samples were immediately laid in an Eppendorf microtube, at the top of 150 t~l oil (a mixture of dibutylphthlate and dioctylphthlate of 1.20 g / m l density) and centrifuged in an Eppendorf centrifuge at 10000 × g for 30 s. The cell's pellet was cut and added to 0.5 ml boiling SDS solution (0.1%) in a scintillation counting vial. After 5 min., 4 ml of a liquid-scintillation cocktail (Aqualuma Lumac, Landgraaf, The Netherlands) was added. Counting was performed in a Beckman/3 counter. In the cases in which the effects of amino acids and their modifiers were tested, experiments were carried out with perfusion buffer which was composed of NaCI (mM): 137, KC1 5.4, Na2HPO 4 • 2H20 3.4, K H 2 P O 4 3.5, M g S O 4 \" 7H20 8.1, NaHCO 3 24.4 and CaCI 2 • 2H20 2.0 (pH 7.6). The extracellular water contamination was measured by adding [14C]sucrose to hepatocyte suspension before centrifugation and determining the amount of radioactivity in the cell pellet. Less than 0.13% of the added radioactivity was present in the pellet. So, the contamination with extracellular water is always largely lower (2.02 + 0.10% (n = 3) of the total radioactivity associated with the cell pellet in [14C]tyramine uptake experiments). Since simple diffusion and transporter-mediated processes coexist in the uptake of tyramine by hepatocytes, the transporter-mediated uptake and ICs0 (the concentration of substance which causes half inhibition of tyramine uptake) was calculated after eliminating the simple diffusion part which accounts for about 25% of the total amount of tyramine taken up by hepatocytes under our experimental conditions. For this reason, tyramine transport mentioned in figures and tables refers to transporter mediated tyramine uptake. The relative affinity was calculated according to the formula of Burgen and Iversen : (IC50 of phenethylamine/Relative affinity = ICs0 of substance) × 100%. All the chemicals were purchased from standard sources. Results\nUptake of tyramine by rat liver and isolated hepatocytes The main source of tyramine in general circulation comes from undeaminated tyramine after its passage through intestine and liver. To determine the proportion of tyramine taken up by the liver after its intestinal absorption, the [~4C]tyramine present in that organ was measured at various time after portal vein injection.\nTime ( rain ) Fig. 1. Uptake of [14C]tyramine by rat liver (A) and isolated hepatocytes (B). (A) Rat liver was perfused for 3 min with ice-cold 0.9% NaCI at various times after injection of [14C]tyramine (3 nmol) to the portal vein. 50 /zl homogenised liver (diluted 4 times with 0.25 M sucrose) was mixed with 4 ml liquid-scintillation cocktail (Aqualuma Lumac, Landgraaf, The Netherlands) before being counted in a Beckman /3 counter. Results are given as percentages of the amount injected to the rat. (B) Freshly isolated rat hepatocytes were incubated with [14C]tyramine (6.6/zM) at 37°C in RPMI 1640 medium. At the indicated times, 66 /zl mixture containing 105 cells were sampled and laid in an Eppendorf microtube, on the surface of 150 /zl oil (a mixture of dibutylphthalate and dioctylphthalate of 1.20 g / ml density) and centrifuged in an Eppendorf centrifuge for 30 s. The treatment of cell's pellet and the radioactivity counting are described in Materials and Methods. The total volume of hepatocytes was estimated according to the data given by Loud . The results are given as either [14C]tyramine (pmoi/mg proteins) () or the ratio of the radioactivity concentration inside (C i) and outside (C o) of the cells ( • ).\nFig. 1A shows that 20 s after injection, 57% of the [14C]tyramine is associated with the liver. Then, the radioactivity quickly decreases with time. Fig 1B illustrates the tyramine uptake by isolated hepatocytes. Five min after adding [14C]tyramine to the cell suspension, the concentration of tyramine within the cells is 17-times higher than that found in the outside medium. After that, its intracellular concentrations quickly diminished. This decrease probably originates from the catabolism of the amine particulary by monoamine oxidase A and B and the fact that the concentration of [14C]tyramine in the medium decreases with time. In fact, we have observed (not shown) that in the presence of chloroquine, an inhibitor of monoamine oxidase, cell radioactivity reaches a higher peak and subsequently, decreases more slowly. However, during the first minute of incubation, the curves with and without chloroquine coincide.\nEffects o f oligomycin, azide, cyanide. 2.4-dinitrophenol and FCCP on the tyramine uptake\n. ~ . . I .....~.o:,%.. ~\n3.106 hepatocytes in 2 ml PRMI 1640 culture medium (pH 7.6) were preincubated with testing substances in the presence of 95% 0 2 + 5% CO 2 at 37°C before performing the transport measurement as described in Materials and Methods.\n ~ ' ~\n, i /\n~ 6001. n\nPreincubation time (min) at 37°C\nTyramine transport (% of control)\nOligomycin 2,4-Dinitrophenol NaN 3 KCN FCCP\n12.5/zM 1 mM 20 mM 20 mM 1 mM\n20 20 40 40 2\n50 32 68 54 1.3\nFig. 2. Kinetic analysis of [14C]tyramine uptake by hepatocytes. The procedure for tyramine transport measurement is as described in Materials and Methods. The curve (a) fitting the experimental points () can be resolved into a saturable process (c) with a Vmax of 270 pmol/min per 105 cells and a K m of 39 /zM as well as a linear uptake (b): v = 1.88.10 -6 [S].\na protonophore, inhibits only at high concentration (1 mM) the penetration of tyramine into hepatocytes (Table I). To investigate the influence of membrane potential on tyramine uptake, chloride was substituted in the perfusion medium by lipophilic anions (NO3, SCN-) and by a hydrophilic, less permeant anion: SO42-. As shown by Table II, in the presence of NO 3 and SCN-,\nGeneral properties of tyramine uptake in hepatocytes\nTyramine c o n c e n t r a t i o n\nThe influence of concentration on tyramine uptake is illustrated in Fig. 2. The curve is biphasic and can be resolved into a linear and a hyperbolic curve with a K m of 39 /zM and a Vm~x of 270 pmol/min/105 cells, suggesting that both simple diffusion and a transporter-mediated mechanism are involved in this uptake process. The carrier-mediated uptake is pH- and temperature-dependent.and requires an activation energy of 12.9 kcal/mol (Q10 = 2.0) (Fig. 3a,b). Adding Mg 2+ATP to the system does not stimulate tyramine transport (data not shown). In the presence of cyanide and azide, inhibitors of respiration, and oligomycin and dinitrophenol, respectively inhibitor and uncoupler of oxidative phosphorylation, the entry of tyramine across the membrane can be blockaded to some extent. FCCP,\nThe influences of N O 3 , S C N - and SO f - on the uptake o f tyramine\nThe isolated hepatocytes were pelleted and suspended in the perfusion buffer where NaC1 (137 mM) was presented or replaced by equal molar of NaNO3, NaSCN or Na2SO 4. With the respective buffer the cells were washed twice at 4°C and resuspended to 6.106 cells/2 ml. 3.105 cells were preincubated for 2 min at 37°C before the uptake measurements which were performed, in the appropriate buffer, according to the procedure described in Materials and Methods. * The differences are significant. Anion\nTyramine transport (% of control, ,g ± S.D., n = 3)\nCl-(control) NO; SCNSO~-\n1 ~ ±1.8 83.6±1.3 76.8±5.4 2.5±0.3\n< 0.01 * < 0.05 * < 0.001 *\n12.9 Keal/tool 8\nFig. 3. Influences of pH and temperature on the [14C]tyramine uptake in hepatocytes. The transport experiments were performed in the medium at various pH (A) at either 4°C ( • ) or 37°C ( ) and at different temperatures (B). The testing steps are those given in Materials and Methods.\nInhibition of [ 14C]tyramine uptake by different substances\nThe uptake of tyramine (6.6 #M) in hepatocytes was measured in the presence of the different substances. All the steps were performed as described in Materials and Methods. The concentration used for the compounds producing 'no effect' is 10 -3 M. It is to be noted that none of the tested compounds affects the diffusion component of the uptake. Where S.E.s are given, the point is the mean value of at least three determinations from two animals. The statistic analysis showed that there were no significant differences for the ICs0 between L-epinephrine and DL-epinephrine as well as between L-norepinephfine and DL-norepinephrine. However, the difference for ICs0 between epinephrine and norepinephrine was significant (P < 0.05). Substance Benztropine Imipramine Atropine Clomipramine Chlorpheniramine Desipramine Chlorpromazine DL-Propranolol Tryptamine Cocaine Amphetamine Phentolamine Tyramine Dopamine Phenethylamine Metaraminol 5-Hydroxytryptamine DJ.-Octopamine DL-Epinephrine L-Dopa c-Isoproterenol Indole Cimetidine Ephedrine Phenylethanolamine 5-Hydoxyindole L-Norepinephrine DL-Norepinephrine Nicotine Carbacholine Histamine Acetylcholine Choline Tyramine-cellobiose Diethylstibestrol Histidine Phenylalanine Tyrosine Tryptophan Ethylamine Reserpine\nICso (M) (X ± S.D.) 3.7.10 - 7 ± 4.9\" 10 s 5.5.10 7 ± 1.5.10-7 1.0- 10 6 1.0- 10 6 1 . 2 - 1 0 - 6 ± 2.4' 10 7 3.0.10 6 5.0.10 6 8.0- 10- 6 8.0.10 - 6 1.1.10 -5 1.8.10-s 2.8.10- 5 3.1.10 s±1.3.10 -s 5.2-10 -5 ±6.5.10 6 8.4.10- 5 ± 4.5- 10 -6 1.1.10- 4 1.4.10 -4 ± 2.4.10 s 1.7.10- 4 1.7' 10 - 4 ± 1.2\" 10 4 2.0\" 10 - 4\n3.0.10-4 + 1.2.10 - 4 3.2.10-4 4.2. ! 0 - 4 4.4.10 - 4 4.8.10 4 6.0.10 - 4 7.6.10 - 4 ±5.6.10 -s 9.0-10-4 ± 1.5.10 - 4 > 1.0.10- 3 No effect No effect No effect No effect No effect No effect No effect No effect No effect No effect No effect No effect\nt h e u p t a k e o f t y r a m i n e is slightly b u t significantly inh i b i t e d , a n d is totally a b o l i s h e d by SO42- .\na m i n e s can inhibit the u p t a k e of t y r a m i n c by h e p a t o cytes, but a m i n o acids and H, N and M r e c e p t o r agonists, for e x a m p l e , tyrosine, t r y p t o p h a n , histamine, nicotine a n d c a r b a c h o l i n e , have no effect. In T a b l e IV, we show the s t r u c t u r a l r e q u i r e m e n t s for the inhibition of t y r a m i n e u p t a k e by its a n a l o g u e s taking p h e n e t h y l a m i n e as the p a r e n t structure. T h e results indicate that: (1) the i n t r o d u c t i o n of a p h e n o l i c hydroxyl g r o u p in p o s i t i o n 4 e n h a n c e s the affinity for the u p t a k e site. T h e p r e s e n c e of a s e c o n d p h e n o l i c hydroxyl g r o u p in p o s i t i o n 3 has no f u r t h e r additive effect in increasing the affinity; (2) the p r e s e n c e of a /3-hydroxyl g r o u p r e d u c e s the affinity. This effect is relatively large when two p h e n o l i c hydroxyl g r o u p s a l r e a d y exist in positions 3 a n d 4, respectively; (3) in the p r e s e n c e of an a - m e t h y l g r o u p the affinity increases. However, in all the cases, with or w i t h o u t the p r e s e n c e of p h e n o l i c hydroxyl groups, the affinities are largely d e p r e s s e d or comp l e t e l y a b o l i s h e d w h e n an a - c a r b o x y l g r o u p is introd u c e d ; (4) the effect o f N - a l k y l a t i o n increases the affinity o f that m o l e c u l e . O t h e r s t r u c t u r a l c h a n g e s can also i n f l u e n c e the affinity. If a b e n z e n e ring is r e p l a c e d by an i m i d a z o l e ring, the affinity d i s a p p e a r s , In contrast, w h e n it is r e p l a c e d by an i n d o l e ring, the affinity is sharply e n h a n c e d . F u r t h e r m o r e , if a hydroxyl g r o u p is i n t r o d u c e d in p o s i t i o n 5 o f the i n d o l e ring the affinity is lost.\nEffects of amino acid modifiers T o gain insight into the m o l e c u l a r c h a r a c t e r i s t i c s of t h e t y r a m i n e t r a n s p o r t we have i n v e s t i g a t e d the sensitivity o f t h e c a r r i e r to p r o t e i n modifiers. A n u m b e r o f m o d i f i e r s have b e e n selected, b o t h on the basis o f assay c o n d i t i o n s which d o not p e r se l e a d to inactivation, as well as on t h e basis o f selectivity, c o n s i d e r i n g t h a t s o m e a m i n o acids are m o r e often e n c o u n t e r e d at t h e active site ( b i n d i n g site) o f p r o t e i n s i n t e r a c t i n g with s u b s t r a t e s [7-10]. T h e results listed in T a b l e V show t h a t significant inhibition o f t y r a m i n e t r a n s p o r t in h e p atocytes was achieved by eight types o f cysteine covalent modifiers. A m o n g them, N E M has the highest affinity for this carrier. S o m e o f the thiol g r o u p r e a c tive agents, P I T C for instance, u n d e r the c o n d i t i o n s e m p l o y e d , can also r e a c t with the lysine residues. However, the lysine-specific r e a g e n t s d o not inhibit tyram i n e t r a n s p o r t ( E A I ) or have a l i m i t e d inhibiting effect even at high c o n c e n t r a t i o n (TNBS). M o d i f i e r s for r e s i d u e s of t r y p t o p h a n (NBS) a n d a r g i n i n e ( P G O ) only have a slight inhibiting effect on the t r a n s p o r t , while D E P , a histidine r e s i d u e modifier, does not affect the uptake. Discussion\nInhibition of tyramine uptake in hepatocytes T h e results r e p o r t e d in T a b l e I I I show t h a t n u m e r ous t y r a m i n e n o n - a n a l o g u e s a n d s y m p a t h o m i m e t i c\nK i n e t i c results show t h a t t y r a m i n e can e n t e r h e p a t o cytes by s i m p l e diffusion a n d by a t r a n s p o r t e r - m e d i a t e d\n81 process requiring an activation energy of 1 2.9 kcal/ mol. The fact that a few min after adding tyramine to cell suspension its intracellular concentration is 17times higher than that of the medium suggests that active transport is involved. Such a hypothesis is supported by observations that cyanide, azide, oligomycin and dinitrophenol inhibit tyramine entry to some extent. The transporter-mediated uptake of tyramine by hepatocytes can be completely depressed by FCCP, a protonophore, but at a concentration that can have non-specific deleterious effects on cells. More significant is the fact that several anions NO3, SCN- and SO42- which can change the normal membrane potential, inhibit tyramine transport, suggesting that the main force driving tyramine transport is membrane potential. The effect on tyramine penetration of covalent side-chain protein modifiers brings additional evidence to the presence of a tyramine transporter in the hepatocyte plasma membrane by giving some information on its structural requirements to be efficient. NEM, at relatively low concentration, suppresses tyramine transport to a large extent, indicating that cysteine is essen-\ntial for a normal carrier function. On the other hand, the null or small effect of other side-chain amino modifiers illustrate that histidine, tryptophan, arginine and lysine are not directly concerned with the binding reaction. Inhibition studies indicate that the hepatocyte tyramine carrier is definitely not involved in amino acid transport. However, they show that several amines which exhibit, like dopamine and tryptamine, or do not exhibit, like benztropine and imipramine, structural homology with tyramine are potent inhibitors of its transport at low concentration. Therefore we cannot exclude the possibility that tyramine carrier might be used by hepatocytes for the transport of various amines. This hypothesis is currently being investigated. From a pharmacological point of view, these observations suggest that some drugs, used in therapeutic medicine, could interfere with the uptake of tyramine by the liver. For example, the efficient antidepressant concentration of imipramine in plasma is between 0.3 and 1 /zM , and a propranolol plasma concentration of up to 4 /xM is required in some ventricular arrhythmias . These concentrations are similar to that causing half inhibition of tyramine uptake in our\nStructural requirements for the inhibition of tyramine uptake by hepatocytes Substance\nCH- CH- NH I\nAmphetamine Tyramine Dopamine Phenethylamine Octopamine L-Dopa (-)-Epinephrine Isoproterenol Phenylethanolamine (-)-Norepinephrine Phenylalanine Tyrosine Tyramine-cellobiose\nH OH OH H OH OH OH OH H OH H OH OH\nH H OH H H OH OH OH H OH H H H\nH H H H OH H OH OH OH OH H H H\nCH 3 H H H H COOH H H H H CCOH COOH H\nH H H H H H CH 3 CH(CH3) 2 H H H H\n467.0 271.0 162.0 100.0 49.4 42.0 28.0 28.0 17.5 11.1 0.0 0.0 0.0\n* They replace the benzene ring of the parent molecule.\n82 TABLE V\nEffects of amino acid modifiers on the uptake of 14C-tyramine hepatocytes The experimental conditions were selected on the basis of the chemical reaction requirements and the tolerance of the carrier to the reaction conditions. 3.106 hepatocytes were incubated in 2 ml perfusion buffer at 25°C with NEM (pH 7.6) or NBS (pH 6.0) for 20 min, or PGO at pH 7.6 for 60 min in a dark room; or DEP (pH 6.0) or pCMB (pH 7.0) for 30 min, or with EMTSA, pAPMA, PITC, iodoacetamide, PMC, pCMPS, EAI and TNBS, respectively, at pH 7.6 for 30 min. The cells were washed two times with 5 ml perfusion buffer at 4°C before the transport measurement was performed in the same medium. Amino acid selectivity\n10 -5 5.10 -5 10 -4 10 -3 10 -5 10 -4 10 3 10 5 10 -4 10 -3 10 -4 10 3 4\" 10 3 8\"10 -3 10 4\n2.10- 4 10 - 3\n88 20 14 0 82 26 1 68 50 0 96 35 14 0 90 30 32 95 17 8 3\n10 - 3 2.10 -3 10 - 3 2.10 -3\n106 102 46 50\n5\" 10 - 4\n10 -3 10 -4 10\nTyramine transport (% of control)\n10 - 3 2\"10 -3 4\" 10 -3\n82 87 69\n5\" 10 -5 10 4\n10 - 3\n10- 3 2.10 -3\nexperiment. Hence, intake of such drugs can inhibit tyramine uptake by the liw=r.\nAcknowledgements This work was supported by the Fonds National de la Recherche Scientifique, the Fonds de la Recherche Scientifique Medicale (contract No. 3.452391) and the ASBL Air Escargot.\nReferences 1 Johnson, R.G., Carty, S.E., Hayflick, S. and Scarpa, A. (1982) Biochem. Pharmacol. 31, 815-823. 2 Blackwell, B. (1963) Lancet ii, 849-851. 3 Hanington, E. (1967) Br. Med. J. 2, 550-558. 4 Seglen, P.O. (1976) Methods Cell Biol. 13, 29-83. 5 Burgen, A.S.V. and Iversen, L.L. (1965) Br. J. Pharmacol. 25, 34-49. 6 Clow, A., Glover, V., Oxenkrug, G.F. and Sandier, M. (1989) Neurosci. Lett. 107, 331-334. 7 Mancini, G.M.S., de Jonge, H.R., Galjarrd, H. and Verheijen, F.W. (1989) J. Biol. Chem. 264, 15247-15254. 8 Riordan, J.F., McElvany, K.D. and Borders, C.L., Jr. (1977) Science 195, 884-886. 9 Vedland, M., Waheed, A., Von Figwra, K. and Pohlmann, R. (1991) J. Biol. Chem. 266, 2917-2923. 10 Bateman, R.C. Jr., Jackson, D., Slaughter, C.A., Unnithan, S., Chai, Y. G., Moomaw, C. and Hersh, L.B. (1989) J. Biol. Chem. 264, 6151-6157. 11 Loud, A.V. (1968)J. Cell Biol. 37, 27-46. 12 Noji, S., Sato, Y., Suzuki, R. and Taniguchi, S. (1988) J. Biochem. 175, 491-495. 13 Johnson, R.G., Cartty, S.E. and Scarpa, A. (1981) J. Biol. Chem. 256, 5773-5780. 14 Glassman, A.H., Perel, J.M., Shostak, M., Kantor, S.J. and Fleiss, J.L. (1977) Arch. Gen. Psychiatry 34, 1 97-204. 15 Regardh, C.G. (1982) Acta Med. Scand. 665, Suppl., 49-60.", "domain": "chemistry", "round": 3} +{"url": "http://www.mdpi.com/1420-3049/22/6/1028", "date": "2018-02-24T02:43:08Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-09/segments/1518891815034.13/warc/CC-MAIN-20180224013638-20180224033638-00552.warc.gz", "language_score": 0.8020879030227661, "token_count": 592, "dump": "CC-MAIN-2018-09", "global_id": "webtext-fineweb__CC-MAIN-2018-09__0__263594471", "lang": "en", "text": "Synthesis and Bioactivity Characterization of Scutellarein Sulfonated Derivative\nAbstractScutellarin (1) has been widely used to treat acute cerebral infarction in clinic, but poor aqueous solubility decreases its bioavailability. Interestingly, scutellarin (1) could be metabolized into scutellarein (2) in vivo. In this study, a sulfonic group was introduced at position C-8 of scutellarein (2) to enhance the aqueous solubility of the obtained derivative (3). DPPH (1,1-diphenyl-2-picrylhydrazyl)-radical scavenging ability and antithrombic activity were also conducted to determine its bioactivity. The result showed that scutellarein derivate (3) could be a better agent for ischemic cerebrovascular disease treatment. View Full-Text\n- Supplementary File 1:\nSupplementary (PDF, 550 KB)\nScifeed alert for new publicationsNever miss any articles matching your research from any publisher\n- Get alerts for new papers matching your research\n- Find out the new papers from selected authors\n- Updated daily for 49'000+ journals and 6000+ publishers\n- Define your Scifeed now\nGu, T.; Zhong, Y.; Lu, Y.-T.; Sun, Y.; Dong, Z.-X.; Wu, W.-Y.; Shi, Z.-H.; Li, N.-G.; Xue, X.; Fang, F.; Li, H.-M.; Tang, Y.-P. Synthesis and Bioactivity Characterization of Scutellarein Sulfonated Derivative. Molecules 2017, 22, 1028.\nGu T, Zhong Y, Lu Y-T, Sun Y, Dong Z-X, Wu W-Y, Shi Z-H, Li N-G, Xue X, Fang F, Li H-M, Tang Y-P. Synthesis and Bioactivity Characterization of Scutellarein Sulfonated Derivative. Molecules. 2017; 22(6):1028.Chicago/Turabian Style\nGu, Ting; Zhong, Yue; Lu, Yu-Ting; Sun, Ying; Dong, Ze-Xi; Wu, Wen-Yu; Shi, Zhi-Hao; Li, Nian-Guang; Xue, Xin; Fang, Fang; Li, He-Min; Tang, Yu-Ping. 2017. \"Synthesis and Bioactivity Characterization of Scutellarein Sulfonated Derivative.\" Molecules 22, no. 6: 1028.\nNote that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.", "domain": "chemistry", "round": 3} +{"url": "http://www.hydro.uni-bayreuth.de/hydro/?lang=en", "date": "2018-05-22T12:11:20Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-22/segments/1526794864725.4/warc/CC-MAIN-20180522112148-20180522132148-00215.warc.gz", "language_score": 0.8563711643218994, "token_count": 339, "dump": "CC-MAIN-2018-22", "global_id": "webtext-fineweb__CC-MAIN-2018-22__0__12676312", "lang": "en", "text": "Welcome to Hydrology!\nThe main focus of research at the Department of Hydrology is the investigation of processes at the interface of groundwater and surface water. This interface is of fundamental importance for numerous processes affecting the quality of surface waters (streams, lakes) as well as groundwater as the two aquatic systems possess different chemical and physical properties. This interface offers ideal conditions for an efficient biological degradation of nutrients and contaminants, meaning that processes at the interface between surface and groundwater contribute considerably to nutrient cycling and buffer capacity in aquatic ecosystems.\nThe department conducts field, lab and modeling investigations that focus on gaining a quantitative process understanding of aquatic systems and address questions of performance and efficiency of matter processing but also vulnerability of aquatic systems, resulting from climate change or anthropogenic influences in general. The overarching goal is to obtain a better understanding of the coupling of physical and biogeochemical processes that control the cycling of matter and energy at the interface of surface waters and groundwater.\nWe have four closely linked research priorities:\nKim, K; Kim, B; Eum, J; Seo, B; Shope, CL; Peiffer, S: Impacts of land use change and summer monsoon on nutrients and sediment exports from an agricultural catchment, Water (2018)\nGilfedder, B; Peiffer, S; Pöschke, F; Spirkaneder, A: Grundwasserzufluss zum Steißlinger See und Folgen für die Wasserchemie, , Grundwasser (2018), doi:https://doi.org/10.1007/s00767-017-0386-8 [Link]", "domain": "chemistry", "round": 3} +{"url": "https://www.broadinstitute.org/publications/broad4105", "date": "2023-03-23T01:18:19Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-14/segments/1679296944606.5/warc/CC-MAIN-20230323003026-20230323033026-00347.warc.gz", "language_score": 0.8147202134132385, "token_count": 552, "dump": "CC-MAIN-2023-14", "global_id": "webtext-fineweb__CC-MAIN-2023-14__0__214111655", "lang": "en", "text": "A chemical screen probing the relationship between mitochondrial content and cell size.\nThe cellular content of mitochondria changes dynamically during development and in response to external stimuli, but the underlying mechanisms remain obscure. To systematically identify molecular probes and pathways that control mitochondrial abundance, we developed a high-throughput imaging assay that tracks both the per cell mitochondrial content and the cell size in confluent human umbilical vein endothelial cells. We screened 28,786 small molecules and observed that hundreds of small molecules are capable of increasing or decreasing the cellular content of mitochondria in a manner proportionate to cell size, revealing stereotyped control of these parameters. However, only a handful of compounds dissociate this relationship. We focus on one such compound, BRD6897, and demonstrate through secondary assays that it increases the cellular content of mitochondria as evidenced by fluorescence microscopy, mitochondrial protein content, and respiration, even after rigorous correction for cell size, cell volume, or total protein content. BRD6897 increases uncoupled respiration 1.6-fold in two different, non-dividing cell types. Based on electron microscopy, BRD6897 does not alter the percent of cytoplasmic area occupied by mitochondria, but instead, induces a striking increase in the electron density of existing mitochondria. The mechanism is independent of known transcriptional programs and is likely to be related to a blockade in the turnover of mitochondrial proteins. At present the molecular target of BRD6897 remains to be elucidated, but if identified, could reveal an important additional mechanism that governs mitochondrial biogenesis and turnover.\n|Year of Publication||\n|PubMed Central ID||\nR01 GM089652 / GM / NIGMS NIH HHS / United States\nR24 DK080261 / DK / NIDDK NIH HHS / United States\nR01GM089652 / GM / NIGMS NIH HHS / United States\nR24DK080261 / DK / NIDDK NIH HHS / United States", "domain": "chemistry", "round": 3} +{"url": "https://pubmed.ncbi.nlm.nih.gov/11785931/", "date": "2021-03-09T04:57:22Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-10/segments/1614178385984.79/warc/CC-MAIN-20210309030723-20210309060723-00136.warc.gz", "language_score": 0.9224448204040527, "token_count": 289, "dump": "CC-MAIN-2021-10", "global_id": "webtext-fineweb__CC-MAIN-2021-10__0__142866262", "lang": "en", "text": "Synthesis of callose (beta-1,3-glucan) in plants has been a topic of much debate over the past several decades. Callose synthase could not be purified to homogeneity and most partially purified cellulose synthase preparations yielded beta-1,3-glucan in vitro, leading to the interpretation that cellulose synthase might be able to synthesize callose. While a rapid progress has been made on the genes involved in cellulose synthesis in the past five years, identification of genes for callose synthases has proven difficult because cognate genes had not been identified in other organisms. An Arabidopsis gene encoding a putative cell plate-specific callose synthase catalytic subunit (CalS1) was recently cloned. CalS1 shares high sequence homology with the well-characterized yeast beta-1,3-glucan synthase and transgenic plant cells over-expressing CalS1 display higher callose synthase activity and accumulate more callose. The callose synthase complex exists in at least two distinct forms in different tissues and interacts with phragmoplastin. UDP-glucose transferase, Rop1 and, possibly, annexin. There are 12 CalS isozymes in Arabidopsis, and each may be tissue-specific and/or regulated under different physiological conditions responding to biotic and abiotic stresses.", "domain": "chemistry", "round": 3} +{"url": "https://iimcb.genesilico.pl/modomics/protein/101/", "date": "2022-11-26T19:43:36Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-49/segments/1669446708046.99/warc/CC-MAIN-20221126180719-20221126210719-00468.warc.gz", "language_score": 0.7367843389511108, "token_count": 529, "dump": "CC-MAIN-2022-49", "global_id": "webtext-fineweb__CC-MAIN-2022-49__0__84387432", "lang": "en", "text": "Modomics - A Database of RNA Modifications\nIscA from Escherichia coli - protein summary.\nIron-binding protein iscA\nIscA is a scaffold protein for the [Fe-S] clusters. It binds ferredoxin, iron and [2Fe-2S] clusters, and participates in the biosynthesis of iron-sulfur proteins, including (dimethylallyl)adenosine tRNA methylthiotransferase MiaB. IscA homolog in human is IscA1, however its function is not clear.\nIron-sulfur cluster assembly: characterization of IscA and evidence for a specific and functional complex with ferredoxin.\nOllagnier-de-Choudens S, Mattioli T, Takahashi Y, Fontecave M\nJ Biol Chem\nFormation of thiolated nucleosides present in tRNA from Salmonella enterica serovar Typhimurium occurs in two principally distinct pathways.\nLeipuviene R, Qian Q, Bjork GR\nSufA/IscA: reactivity studies of a class of scaffold proteins involved in [Fe-S] cluster assembly.\nOllagnier-de-Choudens S, Sanakis Y, Fontecave M...\nJ Biol Inorg Chem\nCopyright © Genesilico - All rights reserved\nIf you have any advice or suggestions for corrections or improvements, please contact:\nAndrea Cappannini -", "domain": "chemistry", "round": 3} +{"url": "https://link.springer.com/article/10.1007/BF00742367", "date": "2018-07-17T22:02:06Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-30/segments/1531676589902.8/warc/CC-MAIN-20180717203423-20180717223423-00436.warc.gz", "language_score": 0.7171045541763306, "token_count": 460, "dump": "CC-MAIN-2018-30", "global_id": "webtext-fineweb__CC-MAIN-2018-30__0__142293345", "lang": "en", "text": "Synthesis of chalcone analogs -4- and 5-nitropyrrole derivatives\n- 115 Downloads\nNitropyrrole analogs of chalcone have been synthesized by aldol condensation in basic medium from 5-nitropyrrole-2-carboxaldehyde, 4- and 5-nitro-2-acetylpyrrole, and the corresponding aromatic aldehydes and methyl ketones; their 2, 4-dinitrophenylhydrazones have been obtained. Some considerations are expressed concerning the reactivity of pyrrole-2-carboxaldehyde, 2-acetylpyrrole, and their nitro derivatives.\nKeywordsMethyl Organic Chemistry Aldehyde Ketone Basic Medium\nUnable to display preview. Download preview PDF.\n- 1.S. V. Tsukerman, V. P. Izvekov, and V. F. Lavrushin, KhGS [Chemistry of Heterocyclic Compounds], 527, 1965.Google Scholar\n- 2.U. S. Patent 2962503; RZhKh, 6L, 279, 1962.Google Scholar\n- 3.A. Corvaisier, Bull., 528, 1962.Google Scholar\n- 4.V. F. Lavrushin, S. V. Tsukerman, and A. I. Artemenko, ZhOKh, 32, 1324, 1329, 1962.Google Scholar\n- 5.S. V. Tsukerman, V. M. Nikitchenko, and V. F. Lavrushin, ZhOKh, 32, 2326, 1962.Google Scholar\n- 6.U. Eisner and R. L. Erskine, J. Chem. Soc., 971, 1958.Google Scholar\n- 7.W. Johnson, and others, Organic Reagents for Organic Analysis [Russian translation], IL, Moscow, 1948.Google Scholar\n- 8.P. Fournari and J. Tirouflet, Bull., 484, 1963.Google Scholar\n- 9.I. J. Rinkes, Rec. trav. chim., 53, 1167, 1934.Google Scholar", "domain": "chemistry", "round": 3} +{"url": "https://scinapse.io/papers/2564740379", "date": "2019-09-16T12:45:07Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-39/segments/1568514572556.54/warc/CC-MAIN-20190916120037-20190916142037-00202.warc.gz", "language_score": 0.8484449982643127, "token_count": 748, "dump": "CC-MAIN-2019-39", "global_id": "webtext-fineweb__CC-MAIN-2019-39__0__83653931", "lang": "en", "text": "Geology, mineralization, and fluid inclusion characteristics of the Skrytoe reduced-type W skarn and stockwork deposit, Sikhote-Alin, Russia\nThe Skrytoe deposit (>145 Kt WO3, average grade 0.449% WO3) in the Sikhote-Alin orogenic system (Eastern Russia) is situated in a metallogenic belt of W, Sn-W, Au, and Au-W deposits formed in a late to post-collisional tectonic environment after cessation of active subduction. It is localized within a mineralized district of reduced-type skarn W and veined Au (±W) deposits and occurrences related to the Early Cretaceous ilmenite-series plutonic suite. The deposit incorporates large stockworks of scheelite-bearing veinlets related to propylitic (amphibole, chlorite, quartz) and phyllic (quartz, sericite, albite, apatite, and carbonate) hydrothermal alteration. The stockwork cuts flat-lying mafic volcanic rocks and limestone partially replaced by pyroxene skarn that host the major W orebodies. Scheelite is associated with pyrrhotite and/or arsenopyrite, with minor chalcopyrite and other sulfide minerals; the late phyllic stage assemblages hosts Bi and Au mineralization. The fluid evolution included low-salinity moderate-temperature, moderate-pressure (∼370–390 °C, ∼800 bars) methane-dominated carbonic-aqueous fluids that formed post-skarn propylitic alteration assemblages. Then, at the phyllic stage, there has been an evolution from methane-dominated, moderate-temperature (330–360 °C), low-salinity (<12.3 wt% NaCl equiv.) fluids forming the early quartz-sericite-albite-arsenopyrite assemblage, through lower temperature (290–330 °C) methane-dominated, low-salinity (∼9–10 wt% NaCl equiv.) fluids forming the intermediate quartz-sericite-albite-scheelite-pyrrhotite assemblage, to yet lower temperature (245–320 °C) CO2-dominated carbonic-aqueous low-salinity (∼1–7 wt% NaCl equiv.) fluids forming the late quartz-sericite-sulfide-Bi-Au assemblage. Recurrent fluid immiscibility (phase separation) and cooling probably affected W solubility and promoted scheelite deposition. The stable isotope data support a sedimentary source of carbon (δ13Cfluid = ∼−21 to −10 ‰), a magmatic source for water (δ18OH2O = +7.4 to +7.7 ‰), and dominantly crustal-derived source of sulfur (δ34S = −4.6 to −2.9 ‰) in the hydrothermal fluids. This is consistent with the development of larger, longer crystallizing crustal intermediate to felsic magma chambers in the late to post-collisional tectonic environment, with their protracted magmatic evolution advancing magmatic differentiation and partitioning of W into magmatic-hydrothermal fluid. The dominating role of the crustal-derived magmatic water, sulfur, and carbon appears to be an important feature of reduced W skarn deposits related to ilmenite-series granitoids.", "domain": "chemistry", "round": 3} +{"url": "http://www.abcam.cn/recombinant-human-fhit-protein-ab95856.html", "date": "2018-03-19T06:38:30Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-13/segments/1521257646602.39/warc/CC-MAIN-20180319062143-20180319082143-00652.warc.gz", "language_score": 0.7235467433929443, "token_count": 360, "dump": "CC-MAIN-2018-13", "global_id": "webtext-fineweb__CC-MAIN-2018-13__0__127884256", "lang": "en", "text": "The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\n% SDS-PAGE. ab95856 is purified using conventional chromatography techniques.\nConcentration information loading...\nShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.\nConstituents: 10% Glycerol, 20mM Tris HCl, pH 8.0\nAP3A hydrolase fragile site 3p14.2\nBis 5' adenosyl triphosphatase\nBis(5' adenosyl) triphosphatase\nDiadenosine 5' 5''' P1 P3 triphosphate hydrolase\nFragile histidine triad\nFragile histidine triad gene\nFragile histidine triad protein\nTumor suppressor protein\nFHIT (fragile histidine triad) cleaves adenosine 5' PPP 5' A to yield AMP and ADP. Alterations and deletions of the FHIT gene are strongly linked to the genesis and establishment of human tumors of the lung, cervix, breast, colon, stomach and pancreas. In normal cells, FHIT may act as a tumor suppressor. FHIT physically associates with ubiquitin conjugating enzyme 9.\nSDS-PAGE - FHIT protein (His tag) (ab95856)\n15% SDS-PAGE showing ab95856 at approximately 17.9kDa (3µg).\nhas not yet been referenced specifically in any publications.", "domain": "chemistry", "round": 3} +{"url": "http://trevorcpzjq.shotblogs.com/about-concrete-companies-los-angeles-ca-5515232", "date": "2019-04-22T16:58:40Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-18/segments/1555578558125.45/warc/CC-MAIN-20190422155337-20190422181337-00113.warc.gz", "language_score": 0.9389861226081848, "token_count": 679, "dump": "CC-MAIN-2019-18", "global_id": "webtext-fineweb__CC-MAIN-2019-18__0__67981446", "lang": "en", "text": "About concrete companies Los Angeles CA\nConcrete is used in significant portions Nearly just about everywhere mankind has a necessity for infrastructure. Concrete is Probably the most commonly employed constructing elements in animal homes and for manure and silage storage structures in agriculture.\nSuperplasticizers (also called significant-vary water-reducers) are a class of plasticizers which have much less deleterious outcomes and can be utilized to raise workability greater than is realistic with traditional plasticizers. Compounds employed as superplasticizers consist of sulfonated naphthalene formaldehyde condensate, sulfonated melamine formaldehyde condensate, acetone formaldehyde condensate and polycarboxylate ethers.\n, and the outcome tend to be cracking, chipping and untimely weathering. Low-cost pavers You should not delay as well to frost motion, so homeowners who invest in hardy pavers are often happier with their sturdiness.\n Offered the scale of your concrete marketplace, and the elemental way concrete is used to form the infrastructure of the fashionable entire world, it can be tough to overstate the job this substance performs today.\nCEMEX maintains a classy, on the web-centered process that allows consumers to trace deliveries in authentic time, obtain invoices and make payments—all with the click of a mouse. For more info on CEMEX Go, Click this link.\nDecorative stones such as quartzite, modest river stones or crushed glass are occasionally extra towards the floor of concrete for any ornamental \"exposed aggregate\" end, well known amid landscape designers.\nThe mix layout relies on the type of construction becoming developed, how the concrete is combined and sent, And just how it is put to type the framework.\nQuite a few varieties of concrete are available, distinguished through the proportions of the most crucial ingredients down below. In this manner or by substitution for your cementitious and aggregate phases, the finished merchandise is often personalized click reference to its application. Energy, density, along with chemical and thermal resistance are variables.\nCombining drinking water with a cementitious product varieties a cement paste by the whole process of hydration. The cement paste glues the mixture with each other, fills voids within just it, and makes it movement much more freely.\nChemical admixtures are materials in the form of powder or fluids that are additional on the concrete to provide it certain attributes not obtainable with simple concrete mixes.\nDuring the curing interval, concrete is ideally maintained at controlled temperature and humidity. To be certain complete hydration throughout curing, concrete slabs will often be sprayed with \"curing compounds\" that create a h2o-retaining movie above the concrete.\nThe Conco Companies have been giving the very best value on concrete providers and items inside the increased L.A. spot considering the fact that 1959. We've been honored to be a part of many noteworthy jobs like the Nokia Theatre, and were just lately awarded work on the historical Los Angeles Hall of Justice.\nIt's deposited in thick layers as a semi-dry material then roller compacted right into a dense, sturdy mass.\nBonding brokers are applied to create a bond involving old and new concrete (normally a variety of polymer) with wide temperature tolerance and corrosion resistance.", "domain": "chemistry", "round": 3} +{"url": "https://research.com/u/il-doo-kim", "date": "2023-12-08T10:26:36Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100739.50/warc/CC-MAIN-20231208081124-20231208111124-00499.warc.gz", "language_score": 0.8475735187530518, "token_count": 887, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__312906860", "lang": "en", "text": "2023 - Research.com Materials Science in South Korea Leader Award\nIl-Doo Kim undertakes multidisciplinary studies into Soap film and Curvature in his work. He connects Curvature with Geometry in his study. His research on Geometry often connects related areas such as Soap film. As part of his studies on Composite material, he often connects relevant areas like Elasticity (physics). His research on Elasticity (physics) frequently connects to adjacent areas such as Composite material. His Thermodynamics study frequently intersects with other fields, such as Marangoni effect. He incorporates Marangoni effect and Surface tension in his research. His Surface tension study frequently intersects with other fields, such as Thermodynamics. He combines Mechanics and Optics in his research.\nThis overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.\nLow voltage flexible organic/transparent transistor for selective gas sensing, photodetecting and CMOS device applications\nIl-Doo Kim;Harry L. Tuller.\nStrong nonlinear current-voltage behaviour in perovskite-derivative calcium copper titanate.\nSung-Yoon Chung;Il-Doo Kim;Suk-Joong L. Kang.\nNature Materials (2004)\nUltrasensitive chemiresistors based on electrospun TiO2 nanofibers.\nIl-Doo Kim;Avner Rothschild;Byong Hong Lee;Dong Young Kim.\nNano Letters (2006)\nThe Role of NiO Doping in Reducing the Impact of Humidity on the Performance of SnO2-Based Gas Sensors: Synthesis Strategies, and Phenomenological and Spectroscopic Studies\nHae Ryong Kim;Alexander Haensch;Il Doo Kim;Nicolae Barsan.\nAdvanced Functional Materials (2011)\nUltrasensitive and Highly Selective Gas Sensors Based on Electrospun SnO2 Nanofibers Modified by Pd Loading\nDae-Jin Yang;Itai Kamienchick;Doo Young Youn;Avner Rothschild.\nAdvanced Functional Materials (2010)\nBifunctional Composite Catalysts Using Co3O4 Nanofibers Immobilized on Nonoxidized Graphene Nanoflakes for High-Capacity and Long-Cycle Li–O2 Batteries\nWon-Hee Ryu;Taek-Han Yoon;Sung Ho Song;Seokwoo Jeon.\nNano Letters (2013)\nElectrospun nanofibers as a platform for advanced secondary batteries: a comprehensive review\nJi-Won Jung;Cho-Long Lee;Sunmoon Yu;Il-Doo Kim.\nJournal of Materials Chemistry (2016)\nThin-Wall Assembled SnO2 Fibers Functionalized by Catalytic Pt Nanoparticles and their Superior Exhaled-Breath-Sensing Properties for the Diagnosis of Diabetes\nJungwoo Shin;Seon Jin Choi;Inkun Lee;Doo Young Youn.\nAdvanced Functional Materials (2013)\nSelective Detection of Acetone and Hydrogen Sulfide for the Diagnosis of Diabetes and Halitosis Using SnO2 Nanofibers Functionalized with Reduced Graphene Oxide Nanosheets\nSeon Jin Choi;Bong Hoon Jang;Seo Jin Lee;Byoung Koun Min.\nACS Applied Materials & Interfaces (2014)\nHeterogeneous Sensitization of Metal-Organic Framework Driven Metal@Metal Oxide Complex Catalysts on an Oxide Nanofiber Scaffold Toward Superior Gas Sensors.\nWon-Tae Koo;Seon-Jin Choi;Sang-Joon Kim;Ji-Soo Jang.\nJournal of the American Chemical Society (2016)\nIf you think any of the details on this page are incorrect, let us know.\nWe appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:", "domain": "chemistry", "round": 3} +{"url": "https://supplementfordiet.com/water-or-h2o/", "date": "2019-10-15T22:15:05Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-43/segments/1570986660323.32/warc/CC-MAIN-20191015205352-20191015232852-00310.warc.gz", "language_score": 0.9748058915138245, "token_count": 585, "dump": "CC-MAIN-2019-43", "global_id": "webtext-fineweb__CC-MAIN-2019-43__0__36823637", "lang": "en", "text": "Water or H2O !\nWater is a particle composed of 2 hydrogen atoms and 1 oxygen atom. It’s chemical formula is H2O. it is normally found in fluid state. rivers ocean and lakes are composed of water. it has actually covered almost 71% of the earth. Distilled water has no shade, preference or smell. if water gets very cold (listed below 0 level Celsius), it freezes and also comes to be ice and if it gets extremely warm (above 100 level Celsius), it boils and also come to be vapor. it can dissolve several thing so it is additionally called the universal solvent. It is crucial forever.\nevery living thing requires water for living. water provides development to plants. human being demands water for living. water assists animal or people to absorb food. water helps make pee. with the help of pee pet or individuals get rid of bad chemicals from their body.\npeople could endure couple of months without food however without water they will certainly make it through just 1 day or 2. some of desert animals could obtain adequate water from their food to live yet other must drink. 97% of water on earth is not fresh only 3 % of water is fresh to drink. The water in seas is salt water however lakes and rivers is typically non salted water. Generally, 70% of fresh water which comes from rivers and lakes is made use of to create food, fruit as well as numerous various other agriculture items. About 10% is made use of in residential applications as well as 20% in industry.\nThe water which comes out from markets or mills includes lots of harmness and air pollution in it. Industrial effluents are among the primary sources of water contamination. It consists of high hazardous natural chemicals, not natural salts, heavy metals, oil and also greases etc. Several locations, consisting of cities as well as villages do not have pure or fresh water to drink, they uses such water in their day-to-day usage. Which is really dangerous as well as damaging for their health and wellness. it creates various conditions. the use of polluted water is not just ravaging for individuals however additionally for animals and birds. It is harmful to human health. unfortunately there are lots of illness bring on by water pollution, and they might be much more harmful than u think. Like HIV, CHOLERA, TYPHOID, DIARRHEA, DENGUE FEVER, TUMMY ACHES, LIVER DAMAGES, KIDNEY DAMAGE, THYROID CONDITION and also many more. Individuals must recognize this and quit consuming such polluted water. While there is not a single action to quit water contamination, there are variety of things through which we could minimize water pollution from our daily life. The best method to minimize contamination from water is not to clean up the contaminated water yet to stop contaminating it.", "domain": "chemistry", "round": 3} +{"url": "https://www.pma.uk.com/2016/06/18/non-atomic-ultrasonic-density-analysers-and-monitors/", "date": "2020-09-29T14:15:56Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-40/segments/1600401643509.96/warc/CC-MAIN-20200929123413-20200929153413-00385.warc.gz", "language_score": 0.9205397963523865, "token_count": 376, "dump": "CC-MAIN-2020-40", "global_id": "webtext-fineweb__CC-MAIN-2020-40__0__201258499", "lang": "en", "text": "Non Nuclear Ultrasonic Slurry Density Monitors.\nDensity monitors from PMA comprise of non-atomic and unique hybrid ultrasonic slurry density sensor technology, the 9600 inline slurry analysers can measure key process variables, such as suspended solids, dissolved solids, or density or even all 4 at the same time. In addition to this, all of our 9600 analysers use full-bore, flow-through technology. These wafer-type sensors are easy to install.\n9600 Ultrasonic Slurry Analyser\nDue to its wafer-style sensors which are very easy to install. The intrusion of sensors is undesirable in slurries due to their high solids content; our sensors do not have to be mounted intrusively. A second major advantage is that this slurry analyser doesn’t use a nuclear source, unlike many slurry thickness measurement devices. This makes 9600 series the leading choice when it comes to measuring TSS, TDS, or density of slurries in a wide range of applications, such as mining slurries, cement and drilling mud.\nThe 9680 from PMA is used to measure concentration, TSS (Total Suspended Solids), or TDS (Total Dissolved Solids). It has one sensor each to measure the speed of sound, temperature, attenuation, and audio resistance. A single PEEK sensor measures these parameters to precisely and evaluates the TSS, TDS, and concentration. Different kinds of PEEK sensors can be installed in model 9680. PMA provides very robust sensors for measuring solids in tanks. We also provide sensors to make in-line measurement of slurries possible if concentrations in slurries are deemed critical. Brine and sodium hydroxide (NaOH) are well known applications for which this model can be used.", "domain": "chemistry", "round": 3} +{"url": "https://experts.umn.edu/en/publications/blood-nanoparticle-interactions-and-in-vivo-biodistribution-impac", "date": "2023-12-09T16:26:19Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100912.91/warc/CC-MAIN-20231209134916-20231209164916-00630.warc.gz", "language_score": 0.9301313757896423, "token_count": 269, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__182333291", "lang": "en", "text": "Theranostic nanoparticles (NPs) cannot reach their target tissue without first passing through blood; however, the influence of blood protein and blood cell interactions on NP biodistribution are not well understood. The current work shows that 30 nm PEGylated gold NPs (GNPs) interact not only with blood proteins as thought before but also with blood cells (especially platelets and monocytes) in vivo and that longer blood circulation correlates strongly with tumor uptake. Further, GNP surface properties such as negative charge or lyophilization had either a minimal (i.e., charge) or 15-fold increase (i.e., fresh vs lyophilized) in blood retention times and tumor uptake. Tumor accumulation was increased over 10-fold by use of a bioactive ligand (i.e., TNF) on the lyophilized GNP surface. Resident macrophages were primarily responsible for the bulk of GNP uptake in liver while spleen uptake was highly surface property dependent and appears to involve macrophages and cellular interaction between the red and white pulp. This study shows that the PEG layer and ligand on the surface of the NP are critical to blood interactions and eventual tumor and RES organ biodistribution in vivo.\n- blood?particle interactions\n- gold nanoparticles", "domain": "chemistry", "round": 3} +{"url": "https://standards.globalspec.com/std/3813560/astm-c932-03", "date": "2022-08-12T00:07:39Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571536.89/warc/CC-MAIN-20220811224716-20220812014716-00418.warc.gz", "language_score": 0.8605561256408691, "token_count": 271, "dump": "CC-MAIN-2022-33", "global_id": "webtext-fineweb__CC-MAIN-2022-33__0__214208282", "lang": "en", "text": "ASTM International - ASTM C932-03\nStandard Specification for Surface-Applied Bonding Compounds for Exterior Plastering\n|Publication Date:||10 June 2003|\n|ICS Code (Cement. Gypsum. Lime. Mortar):||91.100.10|\n1.1 This specification covers minimum requirements for exterior surface-applied bonding compounds for improving the adhesion of cementitious material to concrete or other masonry surfaces or any structurally sound surfaces.\n1.2 This specification also covers test methods for determining performance requirements and physical properties.\n1.3 The values stated in inch-pound units are to be regarded as the standard. The SI metric values given in parentheses are approximate and are provided for information purposes only.\n1.4 The following safety hazards caveat pertains only to the test methods described in Sections 9, 10, 11, and 12 in this specification: This standard does not purport to address all of the safety concerns, if any, associated with its use. It is the responsibility of the user of this standard to establish appropriate safety and health practices and determine the applicability of regulatory limitations prior to use.", "domain": "chemistry", "round": 3} +{"url": "http://www.jcvi.org/cgi-bin/tigrfams/HmmReportPage.cgi?acc=TIGR03369", "date": "2017-04-23T13:49:16Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-17/segments/1492917118707.23/warc/CC-MAIN-20170423031158-00574-ip-10-145-167-34.ec2.internal.warc.gz", "language_score": 0.6625403165817261, "token_count": 399, "dump": "CC-MAIN-2017-17", "global_id": "webtext-fineweb__CC-MAIN-2017-17__0__196797945", "lang": "en", "text": "|Function||cellulose biosynthesis protein BcsE|\n|Domain Trusted Cutoff||244.65|\n|Domain Noise Cutoff||121.30|\n|Mainrole Category||Cell envelope|\n|Subrole Category||Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides|\n|Entry Date||Mar 22 2007 5:09PM|\n|Last Modified||Feb 14 2011 3:27PM|\n|Comment||This protein, called BcsE (bacterial cellulose synthase E) or YhjS, is required for cellulose biosynthesis in Salmonella enteritidis. Its role is this process across multiple bacterial species is implied by the partial phylogenetic profiling algorithm. Members are found in the vicinity of other cellulose biosynthesis genes. The model does not include a much less well-conserved N-terminal region about 150 amino acids in length for most members. Solano, et al. suggest this protein acts as a protease.|\nRM PMID: 11929533\nRT Genetic analysis of Salmonella enteritidis biofilm formation: critical role of cellulose.\nRA Solano C, Garcia B, Valle J, Berasain C, Ghigo JM, Gamazo C, Lasa I\nRL Mol Microbiol. 2002 Feb;43(3):793-808.\nRM PMID: 16930487\nRT Exopolysaccharide-associated protein sorting in environmental organisms: the PEP-CTERM/EpsH system. Application of a novel phylogenetic profiling heuristic.\nRA Haft DH, Paulsen IT, Ward N, Selengut JD\nRL BMC Biol. 2006 Aug 24;4:29.|\n|Genome Property||GenProp0658: cellulose biosynthesis (HMM)|\n© J. Craig Venter Institute | Privacy Statement | Data Disclaimer", "domain": "chemistry", "round": 3} +{"url": "http://tgf-a.com/categories/6795-mbs-monoclonals/8004-tgf-beta-1-antibody", "date": "2023-10-01T02:21:26Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233510734.55/warc/CC-MAIN-20231001005750-20231001035750-00002.warc.gz", "language_score": 0.8195593953132629, "token_count": 458, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__309654842", "lang": "en", "text": "Gene name synonims\nTGF beta 1\nAlso known as\nTGF beta 1\nMouse (Mus musculus)\nELISA (EIA), Western Blot (WB)\nOther gene names\nTGFB1; TGFB1; CED; LAP; DPD1; TGFB; TGFbeta; TGFB; TGF-beta-1; LAP\nSupplied as a liquid in ascitic fluid containing 0.03% sodium azide.\nIf you buy Antibodies supplied by MBS Monoclonals they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.\nHuman (Homo sapiens); Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby.\ntransforming growth factor beta-1; Transforming growth factor beta-1; transforming growth factor beta-1; TGF-beta-1; TGF-beta 1 protein; latency-associated peptide; transforming growth factor, beta 1; N/A\nSpecificity and cross-reactivity\nN/A; Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited. This particular antibody might cross react with speacies outside of the listed ones.\nStorage and shipping\nFor optimal storage conditions, keep the antibody at +4°C. Temperature variations in the range 1°C to 9°C are tolerable. for short term storage. Store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.", "domain": "chemistry", "round": 3} +{"url": "https://biography.omicsonline.org/macao/university-of-macau/tang-zikang-289722", "date": "2022-05-27T00:29:09Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-21/segments/1652662627464.60/warc/CC-MAIN-20220526224902-20220527014902-00535.warc.gz", "language_score": 0.8118144869804382, "token_count": 356, "dump": "CC-MAIN-2022-21", "global_id": "webtext-fineweb__CC-MAIN-2022-21__0__93394158", "lang": "en", "text": "Applied Physics and Materials Engineering\nUniversity of Macau\nTANG Zikang working as professor at Uiversity of Macau. He received his Bachelor's degree from Zhejiang University and Master's from Chinese Academy of Science.\nNano structured electronic materials, Carbon nanotubes, graphene and 2D materials, ZnO crystal thin films, wide-gap semiconductors and their photo-electronic devices\nD. Y. Yong, H. Y. He, Z. K. Tang, S. H. Wei, B. C. Pan, “H-stabilized shallow acceptors in N-doped ZnO”, Phys. Rev. B, 92, 235207 (2015).\nZ. Q. Lin, X. C. Gui, Z. P. Zeng, B. H. Liang, W. J. Chen, M. Liu, Y. Zhu, A. Y. Cao, Z. K. Tang, “Biomimetic Carbon Nanotube Films with Gradient Structure and Locally Tunable Mechanical Property”, Adv. Funct. Mater. 25, 7173-7179 (2015).\nM. M. Chen, D. Y. Yong, C. X. Wu, Z. Shen, A. Q. Chen, Y. Zhu, B. C. Pan, Z. K. Tang, “Stabilization of BeZnO alloy by S incorporation: A density functional theory investigation”, J. Alloys Compounds, 658, 636-641 (2016).", "domain": "chemistry", "round": 3} +{"url": "https://researchrepository.ucd.ie/handle/10197/4936", "date": "2019-02-15T19:37:23Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-09/segments/1550247479101.30/warc/CC-MAIN-20190215183319-20190215205319-00268.warc.gz", "language_score": 0.694890022277832, "token_count": 611, "dump": "CC-MAIN-2019-09", "global_id": "webtext-fineweb__CC-MAIN-2019-09__0__96649059", "lang": "en", "text": "A U-Turn in the Asymmetric Appel Reaction: Stereospecific Reduction of Diastereomerically Enriched Alkoxyphosphonium Salts Allows the Asymmetric Synthesis of P-Stereogenic Phosphanes and Phosphane Boranes\nFiles in This Item:\n|RajendranGilheany_U-turn.pdf||100.42 kB||Adobe PDF||Download|\n|Title:||A U-Turn in the Asymmetric Appel Reaction: Stereospecific Reduction of Diastereomerically Enriched Alkoxyphosphonium Salts Allows the Asymmetric Synthesis of P-Stereogenic Phosphanes and Phosphane Boranes||Authors:||Rajendran, Kamalraj V.\nKudavalli, Jaya S.\nDunne, Katherine S.\nGilheany, Declan G.\n|Permanent link:||http://hdl.handle.net/10197/4936||Date:||5-Apr-2012||Online since:||2013-11-19T09:40:41Z||Abstract:||An efficient one-pot synthesis has been developed of enantioenriched P-stereogenic phosphanes and phosphane boranes from the corresponding racemic phosphanes in excellent yield under asymmetric Appel conditions. The chiral auxiliary (menthol) can also be recovered unchanged. The simple and efficient protocol significantly expands the scope of our asymmetric Appel process. The crucial step in the preparation involves stereospecific reduction of intermediate diastereomeric alkoxyphosphonium salts, which are obtained in the reaction of phosphane, hexachloroacetone, and menthol. Thereby, reaction with LiAlH4 or NaBH4 gives the corresponding phosphanes or phosphane boranes, respectively.||Type of material:||Journal Article||Publisher:||Wiley||Journal:||European Journal of Organic Chemistry||Volume:||2012||Issue:||14||Start page:||2720||End page:||2723||Copyright (published version):||2012 WILEY-VCH Verlag GmbH & Co.||Keywords:||Phosphanes; Boranes; Chirality; Asymmetric synthesis; Reduction||DOI:||10.1002/ejoc.201200285||Language:||en||Status of Item:||Peer reviewed|\n|Appears in Collections:||Chemistry Research Collection|\nShow full item record\nPage view(s) 5086\nThis item is available under the Attribution-NonCommercial-NoDerivs 3.0 Ireland. No item may be reproduced for commercial purposes. For other possible restrictions on use please refer to the publisher's URL where this is made available, or to notes contained in the item itself. Other terms may apply.", "domain": "chemistry", "round": 3} +{"url": "https://iwaponline.com/wst/crossref-citedby/16029", "date": "2022-05-25T03:44:18Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-21/segments/1652662578939.73/warc/CC-MAIN-20220525023952-20220525053952-00096.warc.gz", "language_score": 0.7464840412139893, "token_count": 310, "dump": "CC-MAIN-2022-21", "global_id": "webtext-fineweb__CC-MAIN-2022-21__0__53243612", "lang": "en", "text": "Skip Nav Destination\nConsiderations for the mitigation of nitrate contamination: stable isotopes and insights into the importance of soil processes\nWater Sci Technol (2011) 64 (6): 1254–1260.\nThis article has been cited by the following articles in journals that are participating in CrossRef Cited-by Linking.\nMineral Fertilizer and Manure Effects on Leached Inorganic Nitrogen, Nitrate Isotopic Composition, Phosphorus, and Dissolved Organic Carbon under Furrow Irrigation\n- R. D. Lentz\n- G. A. Lehrsch\nJournal of Environmental Quality (2018) 47 (2): 287.\nUse of δ15 N and δ18 O Values for Nitrate Source Identification under Irrigated Crops: A Cautionary Vadose Zone Tale\n- Shawn E. Loo\n- M. Cathryn Ryan\n- Bernie J. Zebarth\n- Shawn H. Kuchta\n- Denise Neilsen\n- Bernhard Mayer\nJournal of Environmental Quality (2017) 46 (3): 528.\nShorter fries? An alternative policy to support a reduction of nitrogen contamination from agricultural crop production\n- George Somers\n- Martine M. Savard\nEnvironmental Science & Policy (2015) 47: 177.\n- M.M. Stoewer\n- K. Knöller\n- C. Stumpp\nJournal of Hydrology (2015) 524: 753.", "domain": "chemistry", "round": 3} +{"url": "https://www.research.ed.ac.uk/en/publications/oxidized-phospholipid-inhibition-of-toll-like-receptor-tlr-signal", "date": "2023-02-04T05:56:59Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-06/segments/1674764500094.26/warc/CC-MAIN-20230204044030-20230204074030-00827.warc.gz", "language_score": 0.9142084121704102, "token_count": 524, "dump": "CC-MAIN-2023-06", "global_id": "webtext-fineweb__CC-MAIN-2023-06__0__15322538", "lang": "en", "text": "The generation of reactive oxygen species is a central feature of inflammation that results in the oxidation of host phospholipids. Oxidized phospholipids, such as 1-palmitoyl-2-arachidonyl-sn-glycero-3- phosphorylcholine (OxPAPC), have been shown to inhibit signaling induced by bacterial lipopeptide or lipopolysaccharide (LPS), yet the mechanisms responsible for the inhibition of Toll-like receptor (TLR) signaling by OxPAPC remain incompletely understood. Here, we examined the mechanisms by which OxPAPC inhibits TLR signaling induced by diverse ligands in macrophages, smooth muscle cells, and epithelial cells. OxPAPC inhibited tumor necrosis factor-alpha production, I kappa B alpha degradation, p38 MAPK phosphorylation, and NF-kappa B-dependent reporter activation induced by stimulants of TLR2 and TLR4 (Pam(3)CSK(4) and LPS) but not by stimulants of other TLRs (poly(I.C), flagellin, loxoribine, single-stranded RNA, or CpG DNA) in macrophages and HEK-293 cells transfected with respective TLRs and significantly reduced inflammatory responses in mice injected subcutaneously or intraperitoneally with Pam(3)CSK(4). Serum proteins, including CD14 and LPS-binding protein, were identified as key targets for the specificity of TLR inhibition as supplementation with excess serum or recombinant CD14 or LBP reversed TLR2 inhibition by OxPAPC, whereas serum accessory proteins or expression of membrane CD14 potentiated signaling via TLR2 and TLR4 but not other TLRs. Binding experiments and functional assays identified MD2 as a novel additional target of OxPAPC inhibition of LPS signaling. Synthetic phospholipid oxidation products 1-palmitoyl-2-(5-oxovaleryl)-sn-glycero-3-phosphocholine and 1-palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine inhibited TLR2 signaling from similar to 30 mu M. Taken together, these results suggest that oxidized phospholipid-mediated inhibition of TLR signaling occurs mainly by competitive interaction with accessory proteins that interact directly with bacterial lipids to promote signaling via TLR2 or TLR4.", "domain": "chemistry", "round": 3} +{"url": "https://pubmed.ncbi.nlm.nih.gov/17487377/?dopt=Abstract", "date": "2021-01-19T12:57:12Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-04/segments/1610703518240.40/warc/CC-MAIN-20210119103923-20210119133923-00662.warc.gz", "language_score": 0.8883765935897827, "token_count": 324, "dump": "CC-MAIN-2021-04", "global_id": "webtext-fineweb__CC-MAIN-2021-04__0__77919949", "lang": "en", "text": "Chemoresistance is a poor prognostic factor in breast cancer and, thus, presents a significant clinical challenge. The mechanisms of chemoresistance involve multiple complex biological processes. This study aims to identify common contributory factors to chemoresistance in breast cancer by comparing protein expression profiles of chemosensitive MCF-7 breast cancer cells and cells resistant to two different commonly used anti-cancer drugs (adriamycin and paclitaxel). Expression of the ATP binding cassette transporter, P-glycoprotein (P-gp), in breast tumours has previously been found to correlate with poor prognosis in vivo and, accordingly, we confirmed overexpression of P-gp in both adriamycin- and paclitaxel-resistant MCF-7 cells. Using two-dimensional gel electrophoresis and MALDI-TOF peptide mass fingerprinting, we identified 20 proteins differentially expressed between chemosensitive, adriamycin-resistant and paclitaxel-resistant MCF-7 cells. Cytokeratin-8, keratin-19, Hsp-27, 14-3-3 epsilon, annexin-A2 and phosphoglycerate kinase-1 showed altered expression in both adriamycin- and paclitaxel-resistant cells. Validation of a number of these changes was confirmed by Western blotting. Our findings provide further insights into the complex mechanisms of chemoresistance, as well as representing an attractive starting point for the identification of potential protein biomarkers to predict response to chemotherapy in breast cancer in vivo.", "domain": "chemistry", "round": 3} +{"url": "http://montreallimousine.biz/oxidation-reduction-potential-in-groundwater.html", "date": "2019-02-19T05:37:55Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-09/segments/1550247489343.24/warc/CC-MAIN-20190219041222-20190219063222-00494.warc.gz", "language_score": 0.8786335587501526, "token_count": 451, "dump": "CC-MAIN-2019-09", "global_id": "webtext-fineweb__CC-MAIN-2019-09__0__185220494", "lang": "en", "text": "Oxidation reduction potential in groundwater\nAnother common reference to ORP that circulates in the industry, is how dead or alive your water.\nThe voltage relationships for several different reference electrodes at 25 C can be interrelated as follows: For example, if one measured 300 mV using a saturated KCl Ag/AgCl reference(ref2) and wanted to refer it to the standard reduction potential ( E 0 displaystyle E_0 ).So, lets say you decide to use ORP as a means of maintaining a sterile and disease-free environment and you have access to an ORP meter.Both pH and redox potentials are properties of solutions, not of elements or chemical compounds per se, and depend on concentrations, temperature etc.Keeping the killing power constant, at a reading determined to be fit for your application, is critical to keeping pathogens and diseases non-existent in a hydroponic system.Bull Tokyo match promo code free trial 2018 Med Dent Univ (7 161.Jong Tae Jeong, advanced options, email: Freq: DailyWeeklyMonthly, one email with all search results.A solution with a higher (more positive) reduction potential than the new species will have a tendency to gain electrons from the new species (i.e.Reduction potential is measured in volts (V or millivolts (mV).Application for comparison of conventional and conservation agriculture cropping systems.Keywords: Groundwater / Oxidation/reduction Potential / Biogeochemical Activity / Indigenous Bacteria / Changes.1 A study was conducted comparing traditional parts per million chlorination reading and ORP in Hennepin County, Minnesota.Such potential differences actually do corrigé concours attaché territorial interne occur from differences in acidity on biological membranes.\nAlthough the study of ORP contains a lot of twists and terms that seem to be misleading, it is a relatively straightforward factor to control.\nConversely, using a safe oxidizer in your inorganic systems will greatly contribute to maintaining a sterile environment, reducing the likelihood of plants being wiped out by a vicious pathogen.\nIntermediate values are rare and usually a temporary condition found in systems moving to higher or lower pE values.", "domain": "chemistry", "round": 3} +{"url": "https://yycnewcentrallibrary.com/what-does-apud-cells-stand-for/", "date": "2024-04-19T00:11:37Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712296817249.26/warc/CC-MAIN-20240418222029-20240419012029-00428.warc.gz", "language_score": 0.899080753326416, "token_count": 1108, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__37850074", "lang": "en", "text": "What does Apud cells stand for?\namine precursor uptake and decarboxylation\nThe endocrine cells of the gastrointestinal tract are APUD cells. This acronym stands for amine precursor uptake and decarboxylation, after the classical function of the cells, which may relate to their role in hormone synthesis.\nWhat does the Enteroendocrine cells secrete?\nKey points. Enteroendocrine cells produce a range of gut hormones that have key roles in the coordination of food digestion and absorption, insulin secretion and appetite.\nWhat are Dnes cells?\nAPUD cells (DNES cells) constitute a group of apparently unrelated endocrine cells, which were named by the scientist A.G.E. Pearse, who developed the APUD concept in the early 1960s. These cells share the common function of secreting a low molecular weight polypeptide hormone.\nAre Enteroendocrine cells epithelial?\nEnteroendocrine cells are specialized epithelial cells dispersed among mucosal cells of the gastrointestinal tract that represent less than 1% of the entire gut epithelial population.\nWhat are Kulchitsky cells?\nEnterochromaffin (EC) cells (also known as Kulchitsky cells) are a type of enteroendocrine cell, and neuroendocrine cell. They reside alongside the epithelium lining the lumen of the digestive tract and play a crucial role in gastrointestinal regulation, particularly intestinal motility and secretion.\nWhich amino acid is taken up by Apud cells?\namino acid decarboxylase\nDesignation for cells in various organs secreting polypeptide hormones. Cells in this group have certain biochemical characteristics in common: they contain amines, such as catecholamine and 5-hydroxytryptamine; take up precursors of these amines in vivo; and contain amino acid decarboxylase.\nWhat are the two types of Enteroendocrine cells?\nSeveral of the enteroendocrine cell types, notably A, K, and L cells, have subgroups or gradients along the intestine that contain different combinations of products: subgroups of I and L cells contain 5-HT.\nWhere are Dnes cells found?\nEnteroendocrine cells are specialized cells found within the gastrointestinal tract, stomach and pancreas. They produce and release hormones in response to a number of stimuli. The hormones may be released into the bloodstream to generate systemic effects or may be distributed as local messengers.\nWhat are the six hormones of duodenal Enteroendocrine cells?\nSmall intestine preferentially generates EECs-producing cholecystokinin (CCK), secretin, glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptides 1 and 2 (GLP-1, GLP-2), peptide YY (PYY), neurotensin (NT), and serotonin (5-HT).\nWhere are Kulchitsky cells?\nThe bronchial Kulchitsky cells are scattered specific cells which lie close to the basement membrane of the bronchi and bronchioles. Electron microscopy reveals that they contain electron-dense granules similar to that seen in cells with a known endocrine function.\nWhere are Argentaffin cells found?\nThe Argentaffin cells are located randomly in the tube-like depressions of the gastric glands in the wall of the stomach. They are also found within the mucous membrane lining of the intestine. and in These cells are distributed throughout the digestive tract such as the stomach, small intestine and appendix.\nHow are APUD cells related to the digestive system?\nActions of the major digestive hormones secreted by APUD cells APUD cells (DNES cells) constitute a group of apparently unrelated endocrine cells, which were named by the scientist A.G.E. Pearse, who developed the APUD concept in the early 1960s. These cells share the common function of secreting a low molecular weight polypeptide hormone.\nWhat are enteroendocrine cells in the intestine?\nEnteroendocrine cells of the intestine are the most numerous endocrine cells of the body. They constitute an enteric endocrine system as a subset of the endocrine system just as the enteric nervous system is a subset of the nervous system. In a sense they are known to act as chemoreceptors, initiating digestive actions…\nHow did the APUD cell get its name?\nThere are several different types which secrete the hormones secretin, cholecystokinin and several others. The name is derived from an acronym, referring to the following: A mine P recursor U ptake – for high uptake of amine precursors including 5-hydroxytryptophan ( 5-HTP) and dihydroxyphenylalanine ( DOPA ).\nWhich is a recursor in the APUD cell?\nA mine P recursor U ptake – for high uptake of amine precursors including 5-hydroxytryptophan ( 5-HTP) and dihydroxyphenylalanine ( DOPA ). D ecarboxylase – for high content of the enzyme amino acid decarboxylase (for conversion of precursors to amines).", "domain": "chemistry", "round": 3} +{"url": "http://printplant.com/lib/author/admin/page/5", "date": "2021-01-20T12:47:04Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-04/segments/1610703520883.15/warc/CC-MAIN-20210120120242-20210120150242-00482.warc.gz", "language_score": 0.9151114225387573, "token_count": 388, "dump": "CC-MAIN-2021-04", "global_id": "webtext-fineweb__CC-MAIN-2021-04__0__288540707", "lang": "en", "text": "By David A. Dzombak,Rajat S. Ghosh,George M. Wong-Chong\nThe presence of cyanide is an important factor in commercial and municipal wastewater remedy and administration, in remediation of former synthetic fuel plant websites and aluminum construction waste disposal websites, in remedy and administration of residuals from hydrometallurgical gold mining, and in different business operations during which cyanide-bearing wastes have been produced. The complexity of the chemistry and toxicology of cyanide and the danger it poses in numerous environmental contexts make its administration and remediation tremendous demanding. Cyanide in Water and Soil\nis the 1st booklet to provide the state of the art in coping with cyanide throughout quite a lot of business and environmental contexts.\nThe ebook brings jointly present wisdom and data approximately cyanide unencumber to and behaviour within the surroundings, and explores the right way to regulate or remediate those releases. No different broad-based exam of this subject exists. Exploring the anthropogenic and average assets of cyanide within the atmosphere, the authors handle the whole diversity of concerns touching on cyanide destiny, shipping, therapy, and toxicity in water and soil in addition to techniques at present utilized in chance overview and administration. they've got built a cautious stability of intensity and scope of assurance, delivering present references that aid readers examine extra approximately subject matters of specific curiosity.\nAn array of applied sciences is offered for the remedy of cyanide in floor water and groundwater, wastewaters, and infected soils and sludges. those applied sciences span the gamut of organic, chemical, electrolytic, actual, and thermal remedy processing. proposing examples of purposes of the applied sciences hired most ordinarily in municipal and commercial settings, the booklet is an invaluable reference software for engineers, scientists, practitioners, and researchers in academia, business organisations, govt, and engineering and technological know-how consulting firms.", "domain": "chemistry", "round": 3} +{"url": "https://hho-bulgaria.com/en/hydrogen-helium-oxygen-sea-diving/", "date": "2023-12-04T07:29:27Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100525.55/warc/CC-MAIN-20231204052342-20231204082342-00252.warc.gz", "language_score": 0.920792818069458, "token_count": 261, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__162081109", "lang": "en", "text": "Hydrogen-helium-oxygen mixture in humans during open sea divingScientific Research\nPsychophysiological reactions in humans during an open sea dive to 500 m with a hydrogen-helium-oxygen mixture. J Appl Physiol. 1994;76:1113-8\nAbrain JH, Gardette-Chauffour MC, Martinez E, Rostain JC, Lemaire C.\nSix commercial divers were examined for neurological and psychosensorimotor responses during open sea diving at 500 m with a hydrogen-helium-oxygen mixture containing 49% hydrogen. The results showed only moderate neurological symptoms of high-pressure nervous syndrome, while the narcotic effect of hydrogen was detectable as examined by psychosensorimotor tests. Nevertheless, the divers successfully fulfilled the main objective of the operational dive, which was to prove the feasibility of such diving methods by connecting specific elements of an offshore oil installation. Finally, these data support the hypothesis that hydrogen may alleviate some of the symptoms of high-pressure nervous syndrome and may be a useful commercial diving gas because it reduces the density of the breathing mixture and therefore improves living, working and the comfort of divers. However, the present results highlight the importance of research on individual susceptibility to pressurized environments, regardless of breath mixture composition.", "domain": "chemistry", "round": 3} +{"url": "https://caymanmama.com/toyota-six-private-companies-establish-research-association-of-biomass-innovat-press-release/", "date": "2022-08-20T02:03:45Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882573876.92/warc/CC-MAIN-20220820012448-20220820042448-00234.warc.gz", "language_score": 0.8996708393096924, "token_count": 394, "dump": "CC-MAIN-2022-33", "global_id": "webtext-fineweb__CC-MAIN-2022-33__0__200547506", "lang": "en", "text": "The start of research on bioethanol fuel production to achieve carbon neutral society\nTOKYO, July 20, 2022 – (JCN Newswire) – ENEOS Corporation (ENEOS), Suzuki Motor Corporation (Suzuki), Subaru Corporation (Subaru), Daihatsu Motor Co. Ltd. (Daihatsu), Toyota Motor Corporation (Toyota), and Toyota Tsusho Corporation (Toyota Tsusho) established the Research Association of Biomass Innovation for Next Generation Automobile Fuels (Research Association) on July 1, 2022, to study ways to optimize the process of producing fuel.\nIt is crucial to provide diverse energy options to meet the needs of many different regions and customers in order to achieve carbon neutrality. Hydrogen and synthetic fuels based on electricity from renewable energy sources, as well as bioethanol fuel able to reduce CO2 emissions through photosynthesis in plants are promising options, and their effectiveness has been confirmed by the Intergovernmental Panel on Climate Change (IPCC). However, it is essential to clarify the issues and search for a solution regarding CO2 emission reduction and social implementation throughout the manufacturing process, in addition to raw material procurement for any of these fuels.\nThis Research Association promotes technological research on the use of biomass, as well as the efficient production of bioethanol fuel for automobiles through the optimized circulation of hydrogen, oxygen, and CO2 during production to achieve a carbon-neutral society. Specific research areas are as follows.\n1. Research on Efficient Ethanol Production Systems\nWith the aim of improving production technology for second-generation bioethanol fuel that does not compete with food, the Research Association will design, install, and operate production facilities, identify issues with production, research solutions and study ways to improve the efficiency of production systems.\n2. Research on Byproduct Oxygen, CO2 Capture, and Utilization\nThe Research Association will study how to use the high…", "domain": "chemistry", "round": 3} +{"url": "https://www.cheric.org/research/tech/periodicals/view.php?seq=685352", "date": "2022-08-09T22:07:50Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571090.80/warc/CC-MAIN-20220809215803-20220810005803-00318.warc.gz", "language_score": 0.9434148073196411, "token_count": 384, "dump": "CC-MAIN-2022-33", "global_id": "webtext-fineweb__CC-MAIN-2022-33__0__189535743", "lang": "en", "text": "Journal of Applied Microbiology, Vol.97, No.4, 827-837, 2004\nIdentification of denitrifying rhizobacteria from bentgrass and bermudagrass golf greens\nAims: As high rates of nitrogen fertilization are used in turfgrass management, there is a great potential for nitrogen loss. Research on identification of denitrifiers in turfgrass has been limited. Therefore, the aim was to identify denitrifier species and genes from turfgrass roots. Methods and Results: Rhizobacteria were isolated from roots of bentgrass and bermudagrass in sand-based United States Golf Association (USGA) golf greens and used for denitrification biochemical analysis. Seventeen per cent (34 isolates) were identified as denitrifiers, 47% were classified as nitrate-reducers and 36% were nondenitrifiers. Identification of species of the denitrifiers was performed by chromatography fatty acid methyl ester (GC-FAME) and16S rDNA analyses. Bacillus and Pseudomonas were the major turfgrass denitrifiers. The two methods showed a 60% agreement at the genus level. Nitrite reductase genes nirK and nirS were detected in 74 and 15% of the denitrifiers, respectively, but not in nondenitrifiers. The nosZ gene encoding nitrous oxide reductase was detected in all the denitrifiers, but also in some nondenitrifiers. Conclusions: To our knowledge, this is the first report for identification of denitrifiers and denitrification-related genes associated with turfgrass roots. Significance and Impact of the Study: These results provide valuable data for future denitrification studies that seek to improve turfgrass nitrogen management for maximum efficiency.", "domain": "chemistry", "round": 3} +{"url": "https://lightcolourvision.org/dictionary/additive-colour/definition/", "date": "2022-05-18T14:03:54Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-21/segments/1652662522270.37/warc/CC-MAIN-20220518115411-20220518145411-00000.warc.gz", "language_score": 0.9265779852867126, "token_count": 386, "dump": "CC-MAIN-2022-21", "global_id": "webtext-fineweb__CC-MAIN-2022-21__0__270988673", "lang": "en", "text": "About additive colour\n- Additive colour is the method used to mix wavelengths of light, whilst subtractive colour is the method used when mixing pigments such as dyes, inks and paints.\n- An additive approach to colour is used to control the emission of light by the screens of televisions, computers and phones.\n- The additive approach to colour is also used by digital projectors which reflect wavelengths of light off a white surface towards an observer.\n- A colour model can be thought of as a theory of colour whilst additive colour or subtractive colour refers to the method used in practice.\nAdditive colour and the RGB colour model\nThe RGB colour model used by TV, computer and phone screens involves additive colour mixing. The RGB colour model produces all the colours seen by an observer simply by combining the light emitted by arrays of red, green and blue pixels (picture elements) in different proportions.\n- RGB colour is an additive colour model that combines wavelengths of light corresponding with red, green and blue primary colours to produce other colours.\n- Red, green and blue are called additive primary colours in an RGB colour model because just these three component colours can produce any other colour if mixed in the right proportion.\n- Different colours are produced by varying the intensity of the component colours between fully off and fully on.\n- When fully saturated red, green and blue primary colours are combined, they produce white.\n- A fully saturated colour is produced by a single wavelength (or narrow band of wavelengths) of light.\n- When any two fully saturated additive primary colours are combined, they produce a secondary colour: yellow, cyan or magenta.\n- Some RGB colour models can produce over 16 million colours by varying the intensity of each of the three primary colours.\n- The additive RGB colour model cannot be used for mixing pigments such as paints, inks, dyes or powders.", "domain": "chemistry", "round": 3} +{"url": "https://www.naturerepublicusa.com/collections/aloe-vera-collection/products/california-aloe-vera-74-cooling-eye-serum", "date": "2021-08-03T07:48:03Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-31/segments/1627046154432.2/warc/CC-MAIN-20210803061431-20210803091431-00006.warc.gz", "language_score": 0.6911513209342957, "token_count": 389, "dump": "CC-MAIN-2021-31", "global_id": "webtext-fineweb__CC-MAIN-2021-31__0__65191871", "lang": "en", "text": "CALIFORNIA ALOE VERA 74 COOLING EYE SERUM\nThe ingredient of aloe vera leaf juice from California moisturizes skin around the eyes. The ingredient of adenosine reduces fine wrinkles around the eyes. The 3 kinds of refreshing cooling balls revitalize skin around the eyes by massaging tired eye area.\nHOW TO USE:\nAdjust the content of a tube, rolls it over eye rim roundly, get it absorbed like massage.\nFor external use only. Avoid contact with eyes. Discontinue use if signs of irritation or rashes appear. Keep out of reach of children. Replace the cap after use.\nALOE BARBADENSIS LEAF JUICE, GLYCERIN, PEG/PPG-17/6 COPOLYMER, ALCOHOL DENAT., BETAINE, PEG-32, DIPROPYLENE GLYCOL, PENTYLENE GLYCOL, ETHYL HEXANEDIOL, HYDROXYETHYL ACRYLATE/SODIUM ACRYLOYDIMETHYL TAURATE COPOLYMER, WATER, DIMETHICONE, 1,2-HEXANEDIOL, LECITHIN, PEG-40 HYDROGENATED CASTOR OIL, PPG-26-BUTETH-26, ARGININE, ADENOSINE, CARBOMER, DISODIUM EDTA, PHENOXYETHANOL, FRAGRANCE(PARFUM)\n15 ml / 0.5 fl.oz.\nGreat effects on eyes!\nIt’s cool once it’s applied, not sticky or heavy.\nFeels good. I put it on in the morning && evening\nCooling and refreshing, great product for morning and day", "domain": "chemistry", "round": 3} +{"url": "https://www.truniagen.com/blog/science-101/ten-surprising-ways-your-body-uses-nad/", "date": "2023-11-29T19:07:35Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100135.11/warc/CC-MAIN-20231129173017-20231129203017-00899.warc.gz", "language_score": 0.8689762353897095, "token_count": 1588, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__58254917", "lang": "en", "text": "10 Surprising Ways Your Body Uses NAD+\nNAD+ (nicotinamide adenine dinucleotide) is a naturally produced molecule essential for the function of your 37.2 trillion cells. It helps activate mechanisms that generate over 90% of your body’s energy and plays a major role in pretty much all of your body’s vital functions.\nHere are some of the key roles NAD+ plays when it comes to your health:\n1. NAD+ and Aging\nA published study in PLOS One provides quantitative evidence that the depletion of NAD+ may play a significant role in the aging process by regulating cellular energy production, DNA repair, and genomic signaling. NAD+ is an important molecule in all cells and is involved in most biological processes. Research suggests that NAD+ declines by up to 65% between your early thirties and age 70. A 2018 review paper highlights the relationship between NAD+ depletion and age-related health conditions and investigates how boosting NAD+ may support healthier aging.\n2. NAD+ and Hear Health\nNAD+ ensures that your mitochondria produce enough energy to drive cellular function. A decline in mitochondrial count and function in cardiac cells can affect heart health. In conjunction with a healthy diet and regular exercise, boosting your NAD+ levels helps your mitochondria produce the energy required to keep your heart healthy so you don’t skip a beat.\n3. NAD+, Your Nervous System, and Brain\nResearch supports the hypothesis that boosting cellular NAD+ is important for normal brain function. A recent study showed an increase in brain NAD+ with supplementation of an NAD+ precursor in healthy humans. Consequently, NAD+ precursors can help support healthy neurons in the brain.\n4. NAD+ and Muscles\nNAD+ is crucial for your muscle health in two ways. Exercise and movement in general require significant energy, and your muscle cells use NAD+ to help fuel contraction and relaxation. Your cells also need to repair themselves from any damage done by those vigorous sessions at the gym, and cellular repair requires NAD+, too.\n5. NAD+ and Eye Health\nYour tissues and organs need a constant supply of cellular energy to function, and NAD+ plays a crucial role in this supply. One such energy-demanding tissue is the retina. A review article highlighted that declining levels of retinal NAD+ have been linked to health conditions of the retina in preclinical models. UV light exposure can also damage ocular tissues. NAD+ is important in maintaining healthy tissues.\n6. NAD+ and Environmental Stressors\nDaily environmental factors such as smoking and pollution can trigger oxidative stress, leading to a decline in NAD+ and mitochondrial health. Oxidative stress is an imbalance that’s a byproduct of oxygen metabolism and can cause cellular damage. We’re subject to it every day. NAD+ is an important part of the body’s defense against oxidative stress.\n7. NAD+ and Alcohol\nProcessing alcohol in your body is an energy-expensive project, especially in your all-important liver cells. Your body works hard to metabolize and detox when you drink. On a cellular level, this requires your mitochondria (the power generators inside each of your cells) to kick into overdrive. When you drink alcohol, the liver must work to break it down into a substance called acetate. Without NAD+, this process couldn't occur.\n8. NAD+ and Sunlight\nDid you know that excess sun exposure can damage your DNA? The good news is that NAD+ can actually help mend broken DNA strands. It’s required by the repair enzymes that help you and your cells bounce back. Maintaining NAD+ levels helps support a family of enzymes called sirtuins that help maintain cellular health and repair cellular damage.\n9. NAD+, Fat, and Carbs\nNAD+ creation and consumption by your cells is linked to the regulation of fat metabolism and storage. NAD+ also plays an important role in the process of glycolysis, the cycle through which our bodies convert sugars (carbs) into usable energy.\n10. NAD+ and Sleep\nMisaligned circadian rhythms lead to things like jet lag and sleep deprivation. NAD+ helps regulate circadian rhythms, helping keep energy metabolism, hormone regulation, and body temperature variations all in sync and working at their best.\nMassudi, H., Grant, R., Braidy, N., Guest, J., Farnsworth, B., and Guillemin, G. J. (2012). “Age-Associated Changes in Oxidative Stress and NAD+ Metabolism in Human Tissue.” Plos One 7, e42357. doi: 10.1371/journal.pone.0042357.\nJanssens, G. E., Grevendonk, L., Perez, R. Z., Schomakers, B. V., Bosch, J. de V. den, Geurts, J. M. W., et al. (2022). “Healthy Aging and Muscle Function Are Positively Associated with NAD+ Abundance in Humans.” Nat Aging 2, 254–263. doi: 10.1038/s43587-022-00174-3.\nAman, Y., Qiu, Y., Tao, J., and Fang, E. F. (2018). “Therapeutic Potential of Boosting NAD+ in Aging and Age-Related Diseases.” Transl Medicine Aging 2, 30–37. doi: 10.1016/j.tma.2018.08.003.\nLautrup, S., Sinclair, D. A., Mattson, M. P., and Fang, E. F. (2019). “NAD+ in Brain Aging and Neurodegenerative Disorders.” Cell Metab 30, 630–655. doi: 10.1016/j.cmet.2019.09.001.\nVreones et al. (2022) “Oral Nicotinamide Riboside Raises NAD+ and Lowers Biomarkers of Neurodegenerative Pathology in Plasma Extracellular Vesicles Enriched for Neuronal Origin.” Aging Cell Vol. 22, Issue 1. doi: 10.1111/acel.13754.\nJadeja, R. N., Thounaojam, M. C., Bartoli, M., and Martin, P. M. (2020). “Implications of NAD+ Metabolism in the Aging Retina and Retinal Degeneration.” Oxid Med Cell Longev 2020, 2692794. doi: 10.1155/2020/2692794.\nCircu, M. L., and Aw, T. Y. (2010). “Reactive Oxygen Species, Cellular Redox Systems, and Apoptosis.” Free Radical Bio Med 48, 749–762. doi: 10.1016/j.freeradbiomed.2009.12.022.\nPoljsak, B., and Milisav, I. (2016). “NAD+ as the Link Between Oxidative Stress, Inflammation, Caloric Restriction, Exercise, DNA Repair, Longevity, and Health Span.” Rejuv Res 19, 406–413. doi: 10.1089/rej.2015.1767.\nZakhari S. “Overview: How Is Alcohol Metabolized by the Body?” Alcohol Res Health 2006;29(4):245-54. PMID: 17718403; PMCID: PMC6527027.", "domain": "chemistry", "round": 3} +{"url": "https://pubmed.ncbi.nlm.nih.gov/6277381/", "date": "2023-06-04T21:10:10Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-23/segments/1685224650264.9/warc/CC-MAIN-20230604193207-20230604223207-00771.warc.gz", "language_score": 0.9483819603919983, "token_count": 271, "dump": "CC-MAIN-2023-23", "global_id": "webtext-fineweb__CC-MAIN-2023-23__0__124338316", "lang": "en", "text": "Several pyrophosphate analogues have been compared for their ability to inhibit the activities of isolated cytomegalovirus (CMV) DNA polymerase, herpes simplex virus type 1 (HSV 1) DNA polymerase and calf thymus DNA polymerase alpha. The most effective inhibitors were phosphonoformate and phosphonoacetate. Although not identical, the structural requirements for compounds inhibitory to CMV and HSV-1 DNA polymerase were specific, with two negatively charged groups in close vicinity. The CMV DNA polymerase was more susceptible to certain phosphonoacetates containing bulky hydrophobic alpha-substituents than was the HSV-1 DNA polymerase. No example of the converse preference was found. The inhibition of CMV DNA polymerase by phosphonoformate, hypophosphate, alpha-hydroxyphosphonoacetate and alpha-nonylphosphonoacetate was linear non-competitive with the deoxyribonucleoside triphosphates as variable substrates. Phosphonoformate, phosphonoacetate, and to a lesser extent alpha-hydroxyphosphonoacetate, carbonyldiphosphonate and alpha-nonylphosphonoacetate also inhibited the focus formation by CMV in cell-culture.", "domain": "chemistry", "round": 3} +{"url": "https://www.mdpi.com/1996-1944/10/9/1060", "date": "2018-10-17T23:02:24Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-43/segments/1539583511314.51/warc/CC-MAIN-20181017220358-20181018001858-00411.warc.gz", "language_score": 0.8568233251571655, "token_count": 335, "dump": "CC-MAIN-2018-43", "global_id": "webtext-fineweb__CC-MAIN-2018-43__0__221983961", "lang": "en", "text": "Cellulose-Based Smart Fluids under Applied Electric Fields\nAbstractCellulose particles, their derivatives and composites have special environmentally benign features and are abundant in nature with their various applications. This review paper introduces the essential properties of several types of cellulose and their derivatives obtained from various source materials, and their use in electro-responsive electrorheological (ER) suspensions, which are smart fluid systems that are actively responsive under applied electric fields, while, at zero electric field, ER fluids retain a liquid-like state. Given the actively controllable characteristics of cellulose-based smart ER fluids under an applied electric field regarding their rheological and dielectric properties, they can potentially be applied for various industrial devices including dampers and haptic devices. View Full-Text\nShare & Cite This Article\nChoi, K.; Gao, C.Y.; Nam, J.D.; Choi, H.J. Cellulose-Based Smart Fluids under Applied Electric Fields. Materials 2017, 10, 1060.\nChoi K, Gao CY, Nam JD, Choi HJ. Cellulose-Based Smart Fluids under Applied Electric Fields. Materials. 2017; 10(9):1060.Chicago/Turabian Style\nChoi, Kisuk; Gao, Chun Y.; Nam, Jae D.; Choi, Hyoung J. 2017. \"Cellulose-Based Smart Fluids under Applied Electric Fields.\" Materials 10, no. 9: 1060.\nNote that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.", "domain": "chemistry", "round": 3} +{"url": "https://www.research-collection.ethz.ch/handle/20.500.11850/265132", "date": "2019-07-16T02:54:57Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-30/segments/1563195524475.48/warc/CC-MAIN-20190716015213-20190716041213-00319.warc.gz", "language_score": 0.7874346971511841, "token_count": 292, "dump": "CC-MAIN-2019-30", "global_id": "webtext-fineweb__CC-MAIN-2019-30__0__112672834", "lang": "en", "text": "- Journal Article\nRights / licenseCreative Commons Attribution 4.0 International\nQuorum sensing is a promising target for next-generation anti-infectives designed to address evolving bacterial drug resistance. The autoinducer-2 (AI-2) is a key quorum-sensing signal molecule which regulates bacterial group behaviors and is recognized by many Gram-negative and Gram-positive bacteria. Here we report a synthetic mammalian cell-based microbial-control device that detects microbial chemotactic formyl peptides through a formyl peptide sensor (FPS) and responds by releasing AI-2. The microbial-control device was designed by rewiring an artificial receptor-based signaling cascade to a modular biosynthetic AI-2 production platform. Mammalian cells equipped with the microbial-control gene circuit detect formyl peptides secreted from various microbes with high sensitivity and respond with robust AI-2 production, resulting in control of quorum sensing-related behavior of pathogenic Vibrio harveyi and attenuation of biofilm formation by the human pathogen Candida albicans. The ability to manipulate mixed microbial populations through fine-tuning of AI-2 levels may provide opportunities for future anti-infective strategies Show more\nJournal / seriesNature Communications\nPages / Article No.\nPublisherNature Publishing Group\nOrganisational unit03694 - Fussenegger, Martin / Fussenegger, Martin\nMoreShow all metadata", "domain": "chemistry", "round": 3} +{"url": "https://ijettjournal.org/index.php?option=com_content&view=article&id=6559&catid=9", "date": "2023-12-06T13:48:50Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100599.20/warc/CC-MAIN-20231206130723-20231206160723-00602.warc.gz", "language_score": 0.7575131058692932, "token_count": 1670, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__267990271", "lang": "en", "text": "Solid-State Welding Techniques For Polymeric Materials: A State of The Art Review And Future Prospective\n|International Journal of Engineering Trends and Technology (IJETT)||\n|© 2021 by IJETT Journal|\n|Year of Publication : 2021|\n|Authors : Ranvijay Kumar\n|DOI : 10.14445/22315381/IJETT-V69I1P222|\nMLA Style: Ranvijay Kumar. \"Solid-State Welding Techniques For Polymeric Materials: A State of The Art Review And Future Prospective\" International Journal of Engineering Trends and Technology 69.1(2021):139-146.\nAPA Style:Ranvijay Kumar. Solid-State Welding Techniques For Polymeric Materials: A State of The Art Review And Future Prospective International Journal of Engineering Trends and Technology, 69(1), 139-146.\nThe polymers are highly encouraged in engineering applications due to the properties of the excellent material with lightweight structural formations. The joining/welding of the polymeric materials is one of the most needful assembly operation techniques, structures formations, and repairs. The conventional joining techniques like; arc welding or gas welding are not fit for the welding of polymeric materials as they can burn the materials. There are some solid-state joining techniques available that have been largely reported in previous studies. Friction welding (rotary friction welding, linear friction welding, friction stir welding, friction spot welding, and friction stir spot welding), ultrasonic welding, laser welding, and resistance welding are some of the available welding techniques which are reported previously for innovative applications. The present study is a state of the art review of the solid-state welding techniques for the joining of polymeric materials. Also, this study highlights the direction of future studies for the welding of polymeric materials.\n B. Acherjee, A. S. Kuar, S. Mitra, and D. Misra,Effect of carbon black on temperature field and weld profile during laser transmission welding of polymers: A FEM study,Opt. Laser Technol., 44(3)(2012) 514–521.\n A. R. Patel, D. J. Kotadiya, J. M. Kapopara, C. G. Dalwadi, N. P. Patel, and H. G. Rana., Investigation of Mechanical Properties for Hybrid Joint of Aluminium to Polymer using Friction Stir Welding (FSW).,in Materials Today: Proceedings,5(2)(2018) 4242–4249.\n P. Gairola, S. P. Gairola, V. Kumar, K. Singh, and S. K. Dhawan.,Barium ferrite and graphite integrated with polyaniline as effective shield against electromagnetic interference., Synth. Met., 221(2016) 326–331.\n Z. A. Taha, G. G. Roy, K. I. Hajim, and I. Manna.,Mathematical modeling of laser-assisted transmission lap welding of polymers., Scr. Mater., 60(8)(2009) 663–666.\n K. Pal, V. Panwar, S. Friedrich, and M. Gehde.,An investigation on vibration welding of amorphous and semicrystalline polymers., Mater. Manuf. Process., 31(3)(2016) 372–378.\n M. R. Rani, K. Prakasan, and R. Rudramoorthy.,Study of different joints for ultrasonic welding of semicrystalline polymers, Exp. Tech., 33(4)(2009) 36–42.\n U. S. Agarwal and R. A. Mashelkar.,Diffusion of Rigid Rodlike Molecules across Interfaces: Implications in Welding of Liquid Crystalline Polymers, Macromolecules, vol. 25(24)(1992) 6703–6704.\n S. Kumar, M. Kumar, and A. Handa, Combating hot corrosion of boiler tubes – A study,” Eng. Fail. Anal., 94(2018) 379–395.\n M. K. Gupta et al.,Parametric optimization and process capability analysis for machining of nickel-based superalloy., Int. J. Adv. Manuf. Technol.,102,9–12,3995–4009.\n S. Arungalai Vendan, T. Chinnadurai, K. Senthil Kumar, and N. Prakash,Investigations on mechanical and structural aspects of ultrasonic hybrid polymer mixture welding for industrial applications,” Int. J. Adv. Manuf. Technol., 93(2017) 1–4, 89–102.\n N. Panaskar and R. Terkar.,Study of joining different types of polymers by friction stir welding,” Lect. Notes Mech. Eng., (2016) 731–739.\n R. Ghiya and V. J. Badheka.,Review on Friction Stir Welding of Polymer to Aluminium Alloys: Process and Properties., Lect. Notes Mech. Eng., (2021) 221–238.\n B. Acherjee.,Laser transmission welding of polymers – A review on process fundamentals, material attributes, weldability, and welding techniques., J. Manuf. Process., 60(2020) 227–246.\n Lalita, A. P. Singh, and R. K. Sharma.,Synthesis and characterization of graft copolymers of chitosan with NIPAM and binary monomers for removal of Cr(VI), Cu(II) and Fe(II) metal ions from aqueous solutions., Int. J. Biol. Macromol., 99(2017) 409–426.\n B. Acherjee.,State-of-art review of laser irradiation strategies applied to laser transmission welding of polymers., Opt. Laser Technol., (2020).\n T. Chinnadurai, S. Saravanan, M. Karthigai Pandian, N. Prabaharan, and J. Dhanaselvam, “Weld strength analysis of ultrasonic polymer welding using adaptive neuro-fuzzy inference system., Lect. Notes Mech. Eng., (2019) 771–779.\n L. Prabhu and S. Satish Kumar.M.,An application of ccd in rsm to obtain optimize treatment of eccentric-weave friction stir welding between polyether-ether-ketone polymer and AA 6061-T6 with reinforced multiwall carbon nanotubes., Int. J. Mech. Prod. Eng. Res. Dev., 8(6)(2018) 739–754.\n T. Chinnadurai, S. Saravanan, N. Prabaharan, M. K. Pandian, and S. Deebika.,Analyzing the weld strength of ultrasonic polymer welding using Artificial Neural Networks., in Materials Today: Proceedings.,5(14)(2018) 28320–28327.\n K. M. Batoo et al.,Structural, morphological and electrical properties of Cd2+doped MgFe2-xO4 ferrite nanoparticles., J. Alloys Compd., 726(2017) 179–186.\n M. Kaur, H. K. Gianey, D. Singh, and M. Sabharwal.,Multi-objective differential evolution based random forest for e-health applications,Mod. Phys. Lett. B, 33(5)(2019).\n S. G. A. Selvan, M. Selwin, and M. Kalidass.,Laser and friction stir welding behaviour of polymers and polymer composites- A review, Pakistan J. Biotechnol., 14(2017) 16–24.\nFriction stir welding, ultrasonic welding, laser welding, resistance welding, joining, Innovation", "domain": "chemistry", "round": 3} +{"url": "http://agarose-gpg-me.com/index.php?g=Wap&m=Article&a=detail&id=6525", "date": "2021-09-18T16:16:20Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-39/segments/1631780056548.77/warc/CC-MAIN-20210918154248-20210918184248-00037.warc.gz", "language_score": 0.9115145802497864, "token_count": 666, "dump": "CC-MAIN-2021-39", "global_id": "webtext-fineweb__CC-MAIN-2021-39__0__34544982", "lang": "en", "text": "In this study CK C\nIn this study, CK1δ(ΔC) prepared from BL21(DE3)pλPP had the highest kinase activity among the three isoforms tested when using casein as a substrate. Therefore, CK1δ(ΔC) from BL21(DE3)pλPP has the potential to be a “phosphorylating reagent” that may be widely used in experiments of phosphorylation and dephosphorylation of acidic proteins, because CK1s are also known to preferably phosphorylate acidic substrates (e.g., caseins and D4 peptide ). We have previously reported that the catalytic subunit of cAMP-dependent protein kinase (PKAc) and the C-terminal Pyr3 mutant of zebrafish Ca2+/calmodulin-dependent protein kinase Iδ [zCaMKIδ(1–299)] can efficiently phosphorylate acidic/neutral and basic proteins, respectively [35,36]. Given this information, CK1δ(ΔC) prepared from BL21(DE3)pλPP could be an alternative and complement to PKAc and zCaMKIδ(1–299).\nThe novel E. coli strain in which λPPase is constitutively expressed, designated here as BL21(DE3)pλPP, is actually applicable not only for CK1s but also for other PKs (Fig. S2). Besides CK1s, a number of PKs undergo autophosphorylation in E. coli cells, and thus are often prepared as unexpectedly phosphorylated forms [24,37,38]. Because autophosphorylation can largely alter their biochemical properties including kinase activity or binding to their modulators, use of the undesirably autophosphorylated kinase preparations may lead to misunderstanding of bona fide properties of PKs similarly to CK1s. Furthermore, some proteins other than PKs expressed in E. coli may be unexpectedly phosphorylated by endogenous E. coli PKs . Nevertheless, many studies on recombinant PKs and other phosphorylatable proteins have been thus far performed without considering (auto)phosphorylation in E. coli cells.\nNotably, this method is more efficient and generally applicable than the previous method as commonly used expression plasmids such as pET vectors harboring each PK gene can be directly used to transform BL21(DE3)pλPP instead of the conventional BL21(DE3). In contrast, the previous methods need to reconstruct the dedicated expression plasmid from the conventional expression vectors for each PK before transformation . Using the BL21(DE3)pλPP expression system reported here, we can now more readily prepare PKs as “naked” forms, free of undesirable phosphorylations (Fig. 7). Reinvestigation of kinases using this expression method may uncover hidden properties, which have been overlooked so far due to unexpected phosphorylation.\nAcknowledgements This work was supported by JSPS KAKENHI Grant Numbers JP15K07842 to N.S. and JP17J09227 to K.A.", "domain": "chemistry", "round": 3} +{"url": "https://www.sigmaaldrich.com/US/en/tech-docs/paper/1025318", "date": "2022-01-26T06:25:25Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-05/segments/1642320304915.53/warc/CC-MAIN-20220126041016-20220126071016-00478.warc.gz", "language_score": 0.9171661138534546, "token_count": 330, "dump": "CC-MAIN-2022-05", "global_id": "webtext-fineweb__CC-MAIN-2022-05__0__234470004", "lang": "en", "text": "In vivo membrane fusion primarily occurs between highly curved vesicles and planar membranes. A better understanding of fusion entails an accurate in vitro reproduction of the process. To date, supported bilayers have been commonly used to mimic the planar membranes. Soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins that induce membrane fusion usually have limited fluidity when embedded in supported bilayers. This alters the kinetics and prevents correct reconstitution of the overall fusion process. Also, observing content release across the membrane is hindered by the lack of a second aqueous compartment. Recently, a step toward resolving these issues was achieved by using membranes spread on holey substrates. The mobility of proteins was preserved but vesicles were prone to bind to the substrate when reaching the edge of the hole, preventing the observation of many fusion events over the suspended membrane. Building on this recent advance, we designed a method for the formation of pore-spanning lipid bilayers containing t-SNARE proteins on Si/SiO2 holey chips, allowing the observation of many individual vesicle fusion events by both lipid mixing and content release. With this setup, proteins embedded in the suspended membrane bounced back when they reached the edge of the hole which ensured vesicles did not bind to the substrate. We observed SNARE-dependent membrane fusion with the freestanding bilayer of about 500 vesicles. The time between vesicle docking and fusion is ∼1 s. We also present a new multimodal open-source software, Fusion Analyzer Software, which is required for fast data analysis.", "domain": "chemistry", "round": 3} +{"url": "http://mdpi.com/1660-3397/12/6/3138", "date": "2018-02-25T06:06:07Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-09/segments/1518891816138.91/warc/CC-MAIN-20180225051024-20180225071024-00268.warc.gz", "language_score": 0.7950445413589478, "token_count": 658, "dump": "CC-MAIN-2018-09", "global_id": "webtext-fineweb__CC-MAIN-2018-09__0__5774968", "lang": "en", "text": "Investigation of Indolglyoxamide and Indolacetamide Analogues of Polyamines as Antimalarial and Antitrypanosomal Agents\nAbstractPure compound screening has previously identified the indolglyoxy lamidospermidine ascidian metabolites didemnidine A and B (2 and 3) to be weak growth inhibitors of Trypanosoma brucei rhodesiense (IC50 59 and 44 μM, respectively) and Plasmodium falciparum (K1 dual drug resistant strain) (IC50 41 and 15 μM, respectively), but lacking in selectivity (L6 rat myoblast, IC50 24 μM and 25 μM, respectively). To expand the structure–activity relationship of this compound class towards both parasites, we have prepared and biologically tested a library of analogues that includes indoleglyoxyl and indoleacetic “capping acids”, and polyamines including spermine (PA3-4-3) and extended analogues PA3-8-3 and PA3-12-3. 7-Methoxy substituted indoleglyoxylamides were typically found to exhibit the most potent antimalarial activity (IC50 10–92 nM) but with varying degrees of selectivity versus the L6 rat myoblast cell line. A 6-methoxyindolglyoxylamide analogue was the most potent growth inhibitor of T. brucei (IC50 0.18 μM) identified in the study: it, however, also exhibited poor selectivity (L6 IC50 6.0 μM). There was no apparent correlation between antimalarial and anti-T. brucei activity in the series. In vivo evaluation of one analogue against Plasmodium berghei was undertaken, demonstrating a modest 20.9% reduction in parasitaemia. View Full-Text\n- Supplementary File 1:\nSupplementary Materials (ZIP, 26 KB)\nScifeed alert for new publicationsNever miss any articles matching your research from any publisher\n- Get alerts for new papers matching your research\n- Find out the new papers from selected authors\n- Updated daily for 49'000+ journals and 6000+ publishers\n- Define your Scifeed now\nWang, J.; Kaiser, M.; Copp, B.R. Investigation of Indolglyoxamide and Indolacetamide Analogues of Polyamines as Antimalarial and Antitrypanosomal Agents. Mar. Drugs 2014, 12, 3138-3160.\nWang J, Kaiser M, Copp BR. Investigation of Indolglyoxamide and Indolacetamide Analogues of Polyamines as Antimalarial and Antitrypanosomal Agents. Marine Drugs. 2014; 12(6):3138-3160.Chicago/Turabian Style\nWang, Jiayi; Kaiser, Marcel; Copp, Brent R. 2014. \"Investigation of Indolglyoxamide and Indolacetamide Analogues of Polyamines as Antimalarial and Antitrypanosomal Agents.\" Mar. Drugs 12, no. 6: 3138-3160.", "domain": "chemistry", "round": 3} +{"url": "https://fotopharmacy.com/product/avene-cleanance-solaire-spf50-tinted-cream-50ml/", "date": "2023-10-03T19:49:41Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233511220.71/warc/CC-MAIN-20231003192425-20231003222425-00518.warc.gz", "language_score": 0.6820319294929504, "token_count": 663, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__184996189", "lang": "en", "text": "Avene Cleanance Solaire SPF50+ Tinted Cream\nVery high sun protection for faces with sensitive, oily and blemish-prone skin. Enriched with Monolaurin, a sebum-reducing active ingredient, its ultra-light texture mattifies the skin. At the heart of Cleanance Solaire SPF 50+ sun protection, is the exclusive Sunsitive® protection complex developed by Pierre Fabre Research and composed of:\n- A patented filter system containing only four sun filters, for very broad and stable UVB-UVA protection and optimal skin tolerance.\n- A unique antioxidant complex (Pre-tocopheryl + Pro-taurine) for overall protection against oxidative stress.\n- Avène Thermal Spring Water known for its softening, soothing and anti-irritating properties.\nIts airless pump bottle makes it easy to apply the right amount of product.\nHow To Use\nApply all over the face before sun exposure. Repeat often enough for constant protection, especially after sweating, swimming or wiping with a towel. Avoid sun exposure from 11 a.m. to 4 p.m.\nAVENE THERMAL SPRING WATER (AVENE AQUA). C12-15 ALKYL BENZOATE. METHYLENE BIS-BENZOTRIAZOLYL TETRAMETHYLBUTYLPHENOL [NANO]. WATER (AQUA). DIISOPROPYL ADIPATE. ISODECYL NEOPENTANOATE. SILICA. DICAPRYLYL CARBONATE. BIS-ETHYLHEXYLOXYPHENOL METHOXYPHENYL TRIAZINE. DIETHYLHEXYL BUTAMIDO TRIAZONE. ALUMINUM STARCH OCTENYLSUCCINATE. BUTYL METHOXYDIBENZOYLMETHANE\nPOTASSIUM CETYL PHOSPHATE. DECYL GLUCOSIDE. 1,2-HEXANEDIOL. C10-18 TRIGLYCERIDES. GLYCERYL LAURATE. VP/EICOSENE COPOLYMER. ACRYLATES/C10-30 ALKYL ACRYLATE CROSSPOLYMER. BENZOIC ACID. BUTYLENE GLYCOL. CAPRYLIC/CAPRIC TRIGLYCERIDE. DISODIUM EDTA. FRAGRANCE (PARFUM). GLYCERYL BEHENATE. GLYCERYL DIBEHENATE. GLYCERYL STEARATE. OXOTHIAZOLIDINE. PEG-100 STEARATE. PROPYLENE GLYCOL. SODIUM BENZOATE. TOCOPHEROL. TOCOPHERYL GLUCOSIDE. TRIBEHENIN. XANTHAN GUM. ZINC GLUCONATE", "domain": "chemistry", "round": 3} +{"url": "https://www.slideserve.com/leona/egg", "date": "2022-01-20T04:31:55Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-05/segments/1642320301720.45/warc/CC-MAIN-20220120035934-20220120065934-00504.warc.gz", "language_score": 0.7134764790534973, "token_count": 1389, "dump": "CC-MAIN-2022-05", "global_id": "webtext-fineweb__CC-MAIN-2022-05__0__152178342", "lang": "en", "text": "CHAPTER 45 CHEMICAL SIGNALS IN ANIMALS Egg Larva Pupa Adult\nIntroduction • Nervous and endocrine systems are the main internal communication and regulation systems. • The animal hormone-secreting cells constitute the endocrine system. • Hormone secreting organs are called Endocrine Glands (ductless glandsالغدد الصماء). • Hormone is a chemical signal secreted into blood stream and regulates communicating messages within the body. • Target cell is the site that reached by the hormone to which it responds. • Complete changes in the body is regulated by hormones (e.g. metamorphosis in insects). • Types of hormones are [Polypeptide H., Amino acid derivatives H or Steroid H.].\nTropic hormones:الهرمونات المحفزة (المنبهة)target other endocrine glands and are important to understanding chemical coordination. • Many endocrine organs contain specialized nerve cells called neurosecretory cells that secret hormones. • The hormone epinephrine has two functions: • As a hormone of the endocrine system. • As a signal in the nervous system. • Feedback is common in regulation the activity of both endocrine and nervous systems (homeostasis) (Fig. 45.1, page 956): • Calcitonin and parathyroid hormones play an important role in maintaining the concentration of the blood calcium constant. • They are secreted from thyroid and parathyroid glands respictively. • Hormones regulate the development of invertebrates (e.g. insects) See Fig. 45.2, Page 957\nMost chemical signals bind to plasma-membrane proteins, initiating signal-transduction pathways. Mechanism of chemical signaling: The chemical signals secreted by a cell either: I): Protein hormones: Bind to a receptor protein on the surface of the target cell whichwill trigger signal transduction pathway. Fig. 45.3a, Page 959\nII) Steroid hormones: Penetrate the cell and bind to a receptor protein inside the target cell. This also will trigger signal transduction pathway (for triggering mRNA transcription for synthesizing a specific protein). • Estrogen, progesterone, vitamin D and NO. • Usually, the intracellular receptor activated by a hormone is a transcription factor. Fig. 45.3b, Page 959\nالصنوبرية النخامية الدرقية الكظرية The Vertebrate Endocrine System • Tropic hormones (الهرمون المنبه للغدد) • Target other endocrineglands and areimportant to understandingchemical coordination. • Human has 9 endocrine glands. Fig. 45.5, Page 960\nThe hypothalamus and pituitary integrate many functions of the vertebrate endocrine system • The hypothalamus integrates endocrine and nervous function. • Neurosecretory cells of the hypothalamus produce hormones. • Releasing hormones stimulate the anterior pituitary (adenohypophysis) to secrete hormones. • Inhibiting hormones prevent the anterior pituitary from secreting hormones. 1)- Pituitary gland:secrets 9 hormones( 7 hormones by the anterior part and 2 hormones by the posterior part).\nA)- Anterior pituitary hormones. • Growth hormone (GH): a protein. • Stimulates growth and metabolism. • Secretion regulated by hypothalamic hormones. • Acts directly on tissues or acts viagrowth factors. • Gigantism:العملقة excessive GH during development. • Acromegaly: excessive GH production during adulthood. • Hypopituitary dwarfism القزمية: childhood GH deficiency. • Prolactin (PRL): a protein. • Stimulates milk production and secretion from mammary glandالغدد اللبنية. This secretion regulated by hypothalamic hormones. • Gonadotropins (Gonotropic محفز للمناسل): glyocoproteins. • Follicle-stimulating hormone (FSH). • Stimulates production of sperms and ova. • Secretion regulated by hypothalamic hormones. • Luteinizing hormone (LH) المُحفز لتكوين الجسم الأصفر. • Stimulates ovaries and testes. • Secretion regulated by hypothalamic hormones.\nThyroid-stimulating hormone (TSH): a glycoprotein. • Stimulates thyroid gland. • Secretion regulated by thyroxine in blood. • Secretion regulated by hypothalamic hormones. • Adrenocorticotropic hormone (ACTH): a peptide • Stimulates adrenal cortex secretion of glucocorticoids • Secretion regulated by glucocorticoids and hypothalamic hormones. • Melanocyte-stimulating hormone (MSH): a peptide. • May play a role in fat metabolism. • Endorphins: peptides. • Inhibit pain perception. • Effects mimicked by heroin and other opiate drugs.\nMelanocyte-stimulating H. Adrenocorticotropic Also called gonadotropine hormones هرمونات المناسل The anterior pituitary gland hormones Fig. 45.6b, Page 963\nB)- Posterior pituitary hormones. • Oxytocin: a peptide. • Stimulates contraction of the uterus and mammary glands. • Secretion regulated by the nervous system. • Antidiuretic hormone (ADH):مُضاد لإدرار البول a peptide. • Promotes retention of water by the kidneys (in Kidney tubules). • High level decreases urination and viceversa. • Secretion regulated by water/salt balance. • 2- Pineal gland:الغدة الصنوبرية is a small mass of tissue near the center of the mammalian brain and involved in biorhythms. • The pineal gland secretes the hormone, melatonin, an amine. • Involved in biological rhythms associated with reproduction. • Secretion regulated by light/dark cycles.\nAntidiuretic H • Posterior pituitary(neurohypophysis)stores and secretes hormones produced by the hypothalamus. Fig. 45.6a, Page 963", "domain": "chemistry", "round": 3} +{"url": "https://www.ijsr.net/getabstract.php?paperid=SUB141051", "date": "2023-12-08T22:34:09Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100779.51/warc/CC-MAIN-20231208212357-20231209002357-00262.warc.gz", "language_score": 0.9103702902793884, "token_count": 285, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__136653354", "lang": "en", "text": "Downloads: 119 | Views: 193\nResearch Paper | Chemistry | Egypt | Volume 4 Issue 1, January 2015\nCharacterization of Porcelain Stoneware Tiles Based on Solid Ceramic Wastes\nAbstract: Porcelain stoneware tiles get a big role on the market. As well as, considerable quantities of solid wastes are being generated from different industrial activities causing major environmental problems. An attempt to recycle one of these wastes in stoneware tile recipes was introduced to substitute the feldspar. Five formulations were studied on laboratory scale and on production simulation of tile making process, compared with standard one. Partially replaced of fired ceramic waste with feldspar improved, bulk density (2.35-2.42 g/cm3), modulus of rupture reached to 50-70 MPa, resistance of deep abrasion (100-65mm3) slight darkening of color (E around 0.25-2) as well as acceptable coloring. The microstructure has a decisive influence on the mechanical and functional behavior of products. The fired ceramic waste resulting can be incorporated into porcelain stoneware tiles production as economic, technological and environmental correct solution.\nKeywords: stoneware tile, solid wastes, ceramics, porcelain, microstructure\nEdition: Volume 4 Issue 1, January 2015,\nPages: 602 - 608", "domain": "chemistry", "round": 3} +{"url": "https://amaranthineskincare.com/acetyl-hexapeptide-8/", "date": "2020-10-31T18:27:51Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-45/segments/1603107922411.94/warc/CC-MAIN-20201031181658-20201031211658-00134.warc.gz", "language_score": 0.9054575562477112, "token_count": 333, "dump": "CC-MAIN-2020-45", "global_id": "webtext-fineweb__CC-MAIN-2020-45__0__21268751", "lang": "en", "text": "Acetyl Hexapeptide-8 also known as Argireline a peptide used as a cosmetic ingredient that is shown to reduce wrinkles associated with facial expressions. It’s a shortened chemical version of Botulinum toxin (Botox) except Botox is injected into certain areas of the face to relax the muscles. Whereas Acetyl Hexapeptide-8 is a non-toxic, non-irritating ingredient usually a cream that is applied to the skin to stimulates the facial muscles and relaxes the facial tension, reducing the depth and smoothing out fine lines and wrinkles working from the outside.\nHow Does Acetyl Hexapeptide-8 Work\nAcetyl Hexapeptide-8 works by blocking facial muscles to contract when we show facial expressions. This is very important for certain areas of the face such as the forehead when we frown or around the eyes when we squint. Preventing the muscle contraction is essential in preventing new wrinkles or reducing the depth of existing wrinkles. Acetyl Hexapeptide-8 intercepts the message from the brain to the muscle, preventing its contraction. In clinical testing, Acetyl Heaxapeptide-8 has been shown to reduce wrinkles by up to 27% after 30 days. It further prevents new formation of fine lines and wrinkles caused by repeated facial movement and expressions. Most anti-aging creams, serums, or moisturizers that contain Acetyl Hexapeptide-8 will probably include other peptides as their active ingredients to help regenerate skin cells.\nRecommended Product Containing Acetyl Hexapeptide-8", "domain": "chemistry", "round": 3} +{"url": "https://rd.springer.com/article/10.1007/s10600-017-1955-x", "date": "2018-07-18T15:07:19Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-30/segments/1531676590199.42/warc/CC-MAIN-20180718135047-20180718155047-00042.warc.gz", "language_score": 0.7814646363258362, "token_count": 567, "dump": "CC-MAIN-2018-30", "global_id": "webtext-fineweb__CC-MAIN-2018-30__0__133217677", "lang": "en", "text": "Prenylated Dihydrostilbenes from Macaranga rubiginosa\n- 92 Downloads\nPhytochemical isolation of the methanol extract of Macaranga rubiginosa leaves afforded five prenylated dihydrostilbenes. Two of them were known dihydrostilbenes laevifolins A (1) and B (2), while the other three were new compounds, trivially named macarubiginosins A–C (3–5). The structures of the new compounds were elucidated based on their UV, 1D and 2D NMR, and HR-ESI-MS spectral data. Compounds 1–5 were tested for their cytotoxicity against P-388 cells, showing that compound 1 was the most active with IC50 4.3 μM.\nKeywordsmacarubiginosins A–C laevifolins A and B prenylated dihydrostilbenes Macaranga rubiginosa Euphorbiaceae cytotoxicity P-388 cells\nPart of this work is supported by the KK Research Grant (Contract No. 1763/I1.B04.1/KU/2015), Bandung Institute of Technology. The authors also thank the staff of Herbarium Bogoriense, Center of Biological Research and Development, National Institute of Science, Bogor, Indonesia, for identification of the plant specimen.\n- 3.D. Priatna, K. Kartawinata, and R. Abdulhadi, Reinwardtia, 12, 237 (2004).Google Scholar\n- 8.Y. M. Syah and E. L. Ghisalberti, Nat. Prod. J., 2, 45 (2012).Google Scholar\n- 10.N. Ahmat, I. M. Said, J. Latip, L. B. Din, Y. M. Syah, and E. H. Hakim, Nat. Prod. Commun., 2, 1137 (2007).Google Scholar\n- 11.T. Ersam, S. A. Achmad, E. L. Ghisalberti, E. H. Hakim, and Y. M. Syah, J. Chem. Res. (S), 186 (2002).Google Scholar\n- 13.S. Sahidin, E. H. Hakim, L. D. Juliawaty, Y. M. Syah, L. B. Din, E. L. Ghisalberti, J. Latip, I. M. Said, and S. A. Achmad, Z. Naturforsch., 60c, 723 (2005).Google Scholar", "domain": "chemistry", "round": 3} +{"url": "https://www.degruyter.com/journal/key/ijmr/0/0/html", "date": "2022-10-04T03:53:59Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-40/segments/1664030337473.26/warc/CC-MAIN-20221004023206-20221004053206-00312.warc.gz", "language_score": 0.9420977830886841, "token_count": 339, "dump": "CC-MAIN-2022-40", "global_id": "webtext-fineweb__CC-MAIN-2022-40__0__26243744", "lang": "en", "text": "Renewable fuel is gaining more attention in the current energy crisis, and biomass is one of the potential sources of producing renewable fuel. The objective of the present research is to analyze the pyrolysis and kinetic behavior of neem seed biomass. Pyrolysis and kinetic behavior of neem seed were analyzed using thermogravimetric analysis (TGA) at different heating rates, viz. 5, 10, 15, and 20 K min −1 . The kinetic study was conducted on the neem seed using various kinetic models such as Friedman, Kissinger, Flynn–Wall–Ozawa (FWO), and Kissinger–Akahira–Sunose (KAS). Thermodynamic analysis was carried out using the data extracted from the TGA curves. The results showed that the neem seed degraded in three stages, stage I: <100 °C, stage II: 100–550 °C, and stage III: >550 °C. A maximum mass loss of 73.14 % occurred at stage II owing to the loss of cellulose and hemicellulose. The activation energy determined by Friedman, KAS, and FWO models was 5.11–18.64, 10.62–57.41, and 13.77–61.51 kJ mol −1 , respectively. Thermodynamic analysis revealed that the pyrolysis of neem seed was an endothermic and spontaneous process. Moreover, the previously reported average activation energy required for the pyrolysis of various seeds and shells was compared with the present study and concluded that the variation in activation energy of neem seed adheres to the outcomes reported earlier.", "domain": "chemistry", "round": 3} +{"url": "https://biochem.oregonstate.edu/news-events/news-briefs/accessing-isotopically-labeled-proteins-containing-genetically-encoded", "date": "2023-09-28T14:54:21Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233510412.43/warc/CC-MAIN-20230928130936-20230928160936-00501.warc.gz", "language_score": 0.9001644253730774, "token_count": 339, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__236696384", "lang": "en", "text": "Check out the latest publication from the Mehl/Cooley & Barbar Labs!\nAccessing isotopically labeled proteins containing genetically encoded phosphoserine for NMR with optimized expression conditions\nPhosphoserine (pSer) sites are primarily located within disordered protein regions, making it difficult to experimentally ascertain their effects on protein structure and function. Therefore, the production of 15N- (and 13C)-labeled proteins with site-specifically encoded pSer for NMR studies is essential to uncover molecular mechanisms of protein regulation by phosphorylation. While genetic code expansion technologies for the translational installation of pSer in Escherichia coli are well established and offer a powerful strategy to produce site specifically phosphorylated proteins, methodologies to adapt them to minimal or isotope-enriched media have not been described. This shortcoming exists because pSer genetic code expansion expression hosts require the genomic ΔserB mutation, which increases pSer bioavailability but also imposes serine auxotrophy, preventing growth in minimal media used for isotopic labeling of recombinant proteins. Here, by testing different media supplements, we restored normal BL21(DE3) ΔserB growth in labeling media but subsequently observed an increase of phosphatase activity and mis-incorporation not typically seen in standard rich media. After rounds of optimization and adaption of a high-density culture protocol, we were able to obtain ≥10 mg/L homogenously labeled, phosphorylated superfolder GFP. We propose this cost-effective methodology will pave the way for more routine access to pSer-enriched proteins for 2D and 3D NMR analyses.", "domain": "chemistry", "round": 3} +{"url": "https://risreport.com/31/23/47/global-rare-earth-elements-market-2018-2023-insight-dynamic-key-players-applications-and-regions/", "date": "2019-03-26T17:05:58Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-13/segments/1552912205597.84/warc/CC-MAIN-20190326160044-20190326182044-00092.warc.gz", "language_score": 0.8215283155441284, "token_count": 991, "dump": "CC-MAIN-2019-13", "global_id": "webtext-fineweb__CC-MAIN-2019-13__0__90087132", "lang": "en", "text": "Rare Earth Elements Market report (Request Sample Copy) focuses on analysing the key inferences, current market scenario, and mainly on the global and regional market. Rare Earth Elements Market is providing information on major players like manufacturers, suppliers, distributors, traders, customers, drivers, investors and etc.,\nThe data type of Rare Earth Elements market includes capacity, production, market share, price, revenue, cost, gross, gross margin, growth rate, consumption, import, export and etc. Moreover, Rare Earth Elements market established the Industry chain, manufacturing process, cost structure, marketing channel are also analyzed in this report.\nRare Earth Elements market is expected to register a CAGR of about XX% over the forecast period, 2018-2023.\nAsk for Rare Earth Elements Market Sample Report Here @ http://industryresearch.co/enquiry/request-sample/13101820\nGeographically, Rare Earth Elements market is including major types, major applications from major regions such as\nChina, India, Japan, South Korea, ASEAN Countries, Australia & New Zealand, Rest of Asia-Pacific.\nCompetitor Analysis of Rare Earth Elements Market:\nRare Earth Elements market includes following leading manufacturers on the basis of sales, revenue, price, and gross margin.\nAlkane Resources Ltd., Aluminum Corporation of China Ltd., Arafura Resources Limited, Avalon Advanced Materials Inc., China Minmetals Corporation, China Nonferrous Metal Industrys Foreign Engineering and Construction Co., Ltd., Caeneus Minerals Ltd, Eutectix, Galaxy Resources Ltd., Ganzhou Rare Earth Group.Co., Ltd., Iluka Resources Ltd., Inner Mongolia Baotou Steel Rare-Earth (group) Hi-tech Co., Ltd, International Ferro Metals Limited, Lynas Corporation Ltd., Medallion Resources, Northern Minerals Limited, Orbite Technologies Inc., Peak Resources Limited, Quest Rare Minerals Ltd, Rare Element Resources, Rising Nonferrous Metals Share Co., Ltd., Shin-Etsu Chemical Company, Stans Energy Corp., Tantalus Rare Earths AG, Ucore Rare Metals Inc., Xiamen Tungsten Co., Ltd.\nThe price margins for the products along with the various success and risk factors for manufacturers have also been covered in the Rare Earth Elements market report. Moreover, in order to determine Rare Earth Elements market attractiveness, the report analyses the Rare Earth Elements industry along the parameters of Porters five forces model.\nKey Developments in the Rare Earth Elements Market:\nFor More Enquiry, Visit @ http://industryresearch.co/enquiry/pre-order-enquiry/13101820\nRare Earth Elements Market Dynamics\n– High Demand from Emerging Economies\n– Dependency of Green Technology on REE\n– Inconsistent Supply\n– Illegal Mining of REE\n– Increasing Scandium Usage in Aerospace Applications\nRare Earth Elements Market Report Contain:\n– Analysis of the Rare Earth Elements market including revenues, future growth, market outlook\n– Historical data and forecast to 2023\n– Regional analysis including growth estimates\n– Analyzes the end user markets including growth, share, and size.\n– Profiles on Rare Earth Elements market including products, sales/revenues, and market position\n– Market structure, market drivers and restraints.\nReasons to Buy Rare Earth Elements Market Report:\nThe Rare Earth Elements market research study reveals hidden insights and dynamic, which in turn helps the players in the ecosystem take better strategic decisions.\n-The firms looking for purchasing the Rare Earth Elements market research report could look for following prospects on their way to better understand the Rare Earth Elements market that can aid further decision making and possibly identify the opportunities to achievement.\n– Evaluate the qualitative and quantitative aspects of the report and analyze the Rare Earth Elements market penetration with respect to industries and geographies.\n– Evaluate the key vendors in the Rare Earth Elements market in terms of products satisfaction and business strategy. This helps to identify consumer preferences and understand its current position.\n– Evaluates the key vendors and deeply analyze competitive landscape, revenue pockets, market trends, growth prospects, pain points, drivers, restraints, challenges and opportunities of the Rare Earth Elements market.\nPrice of Report: $ 4250 (Single User Licence)\nPurchase Rare Earth Elements Market Report @ http://industryresearch.co/purchase/13101820\nAbout Industry Research:\nIndustry Research is an upscale platform to help key personnel in the business world in strategizing and taking visionary decisions based on facts and figures derived from in-depth market research. We are one of the top report resellers in the market, dedicated to bringing you an ingenious concoction of data parameters.\nName: Ajay More\nOrganization: Industry Research Co.\nPhone : +1424 253 0807", "domain": "chemistry", "round": 3} +{"url": "https://inuuniqvillage.com/read/crc-materials-science-and-engineering-handbook-third-edition", "date": "2022-10-07T21:56:00Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-40/segments/1664030338280.51/warc/CC-MAIN-20221007210452-20221008000452-00382.warc.gz", "language_score": 0.8219521641731262, "token_count": 1146, "dump": "CC-MAIN-2022-40", "global_id": "webtext-fineweb__CC-MAIN-2022-40__0__103500752", "lang": "en", "text": "By James F. Shackelford, William Alexander\nThe CRC fabrics technological know-how and Engineering instruction manual, 3rd version is the main accomplished resource to be had for facts on engineering fabrics. equipped in an easy-to-follow structure in line with fabrics houses, this definitive reference beneficial properties information demonstrated via significant specialist societies within the fabrics box, akin to ASM foreign and the yank Ceramic Society. The 3rd variation has been considerably multiplied, such a lot significantly by means of the addition of latest tabular fabric for quite a lot of nonferrous alloys and diverse composite fabrics.\nFor engineers making, picking, or comparing fabrics, this one, compact quantity presents the proper start line. it's enormously effortless to search-the authors have geared up it based on fabrics houses, supplied a key notice indexing approach, and put many information units in a handy choice part the place fabrics will be in comparison by means of estate price, a characteristic perfect for layout applications.\nA bestseller on account that its first version, the CRC fabrics technology and Engineering guide stands on my own as a the consummate reference for facts at the complete spectrum of engineering fabrics\nRead or Download CRC Materials Science and Engineering Handbook, Third Edition PDF\nBest polymers & textiles books\nThe authors supply a close remedy of varied features of nanocomposites. They describe various fabrication tools, like a thermal spray strategy, or mechanical alloying. Plus, unsurprisingly, tips on how to use carbon nanotubes as a foundation for composites. one other huge crew of equipment revolves round utilizing polymers.\nContent material: regulate of plant phone wall biogenesis : an summary / D. H. Northcote -- Formation and capabilities of xyloglucan and derivatives / David A. Brummell and Gordon A. Maclachlan -- towards a operating version of the starting to be plant mobilephone wall : phenolic cross-linking reactions within the basic phone partitions of dicotyledons / Stephen C.\nContent material: Chemical and fabrics from renewable assets / Joseph J. Bozell -- Polyhydroxyalkanoates: the reply to sustainable polymer construction / Tillman U. Gerngross -- imaginative and prescient for renewable assets / James S. Mclaren -- Synthesis of đ-aminolevulinic acid / Luc Moens -- Levulinate esters from biomass wastes / Edwin S.\nMicrospheres and microcapsules have very huge purposes in a variety of fields, specifically in these of biotechnology and biopharmaceuticals, as focusing on drug-delivery companies, separation media for protein, peptide, DNA, etc. it's a colossal problem to layout and get ready microspheres and microcapsules of alternative sizes and constructions from a number of fabrics and boost new options.\n- The Statistical Nature of Strength and Lifetime in Polymer Films and Fibers (New Concepts in Polymer Science)\n- Handbook of Antistatics\n- The Chemistry of Radical Polymerization, Second Edition\n- Polymeric Drugs and Drug Delivery Systems\n- Surface Modification of Textiles (Woodhead Publishing Series in Textiles)\nExtra info for CRC Materials Science and Engineering Handbook, Third Edition\nM. Goldschmidt, who assigned radii based on known interatomic distances in various ionic crystals. 3 Structure Page 24 Wednesday, December 31, 1969 17:00 Structural Properties Table 9. 165 Source: Data from R. A. Flinn and P. K. Trojan, Engineering Materials and Their Applications, Houghton Mifflin Company, Boston, 1975. The ionic radii are based on the calculations of V. M. Goldschmidt, who assigned radii based on known interatomic distances in various ionic crystals. 3 Structure Page 25 Wednesday, December 31, 1969 17:00 Structural Properties Table 9.\nWeast, R. , 1988, F-167. 3 Structure Page 30 Wednesday, December 31, 1969 17:00 Structural Properties Table 10. , Weast, R. , 1988, F-167. 4 Structure L Page 31 Wednesday, December 31, 1969 17:00 Table 11. 5 Structure Page 32 Wednesday, December 31, 1969 17:00 Structural Properties Table 12. CARBON BOND (SHEET 1 OF 3) LENGTHS Group No. Element. At. No. Sym. 24 1. 016 Bond Type Alkyls (CH3XH3) Alkyls (CH3XH3) Alkyls (CH3XH3) Alkyls (CH3XH3) Aryls (C6H5XH3) Neg. Subst. (CH3XCI3) Alkyls (CH3XH3) Neg.\nAVAILABLE STABLE ISOTOPES OF THE ELEMENTS (SHEET 10 OF 11) Natural Mass No. , Cleveland, 1969, 25. 1 Structure Page 15 Wednesday, December 31, 1969 17:00 Structural Properties Table 2. AVAILABLE STABLE ISOTOPES OF THE ELEMENTS (SHEET 11 OF 11) Natural Mass No. , Cleveland, 1969, 25. 3 x 109 y. 5 x 109 y † naturally occurring. 2 Structure L Page 16 Wednesday, December 31, 1969 17:00 1 IA 2 3 4 5 Table 3. 2 Structure L Page 17 Wednesday, December 31, 1969 17:00 Table 4. 2 Structure L Page 18 Wednesday, December 31, 1969 17:00 Table 5.", "domain": "chemistry", "round": 3} +{"url": "https://prosite.expasy.org/doc/PS01238", "date": "2019-04-25T20:46:23Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-18/segments/1555578733077.68/warc/CC-MAIN-20190425193912-20190425215036-00007.warc.gz", "language_score": 0.8324624300003052, "token_count": 682, "dump": "CC-MAIN-2019-18", "global_id": "webtext-fineweb__CC-MAIN-2019-18__0__153492144", "lang": "en", "text": "A number of nucleoside diphosphate and triphosphate hydrolases as well as some\nyet uncharacterized proteins have been found to belong to the same family [1,2]. This family currently consist of:\nYeast guanosine-diphosphatase (EC 18.104.22.168) (GDPase) (gene GDA1). GDA1 is\na golgi integral membrane enzyme that catalyzes the hydrolysis of GDP to\nPotato apyrase (EC 22.214.171.124) (adenosine diphosphatase) (ADPase). Apyrase\nacts on both ATP and ADP to produce AMP.\nMammalian vascular ATP-diphosphohydrolase (EC 126.96.36.199) (also known as\nlymphoid cell activation antigen CD39).\nToxoplasma gondii nucleoside-triphosphatases (EC 188.8.131.52) (NTPase). NTPase\nhydrolyses various nucleoside triphosphates to produce the corresponding\nnucleoside mono- and diphosphates. This enzyme is secreted into the\ninvaded host cell into the parasitophorous vacuole, a specialized\ncompartment where the parasite intracellulary resides.\nPea nucleoside-triphosphatases (EC 184.108.40.206) (NTPase).\nCaenorhabditis elegans hypothetical protein C33H5.14.\nCaenorhabditis elegans hypothetical protein R07E4.4.\nYeast chromosome V hypothetical protein YER005w.\nThe above uncharacterized proteins all seem to be membrane-bound.\nAll these proteins share a number of conserved domains. We have selected the\nbest conserved of these domains. It is located in the central section of the\nDecember 2004 / Pattern and text revised.\nPROSITE method (with tools and information) covered by this documentation:\nHanda M. Guidotti G.\nPurification and cloning of a soluble ATP-diphosphohydrolase (apyrase) from potato tubers (Solanum tuberosum).\nVasconcelos E.G. Ferreira S.T. de Carvalho T.M.U. de Souza W. Kettlun A.M. Mancilla M. Valenzuela M.A. Verjovski-Almeida S.\nPartial purification and immunohistochemical localization of ATP diphosphohydrolase from Schistosoma mansoni. Immunological cross-reactivities with potato apyrase and Toxoplasma gondii nucleoside triphosphate hydrolase.\nPROSITE is copyright. It is produced by the SIB Swiss Institute\nBioinformatics. There are no restrictions on its use by non-profit\ninstitutions as long as its content is in no way modified. Usage by and\nfor commercial entities requires a license agreement. For information\nabout the licensing scheme send an email to\nor see: prosite_license.html.", "domain": "chemistry", "round": 3} +{"url": "http://www.abcam.cn/lysozyme-antibody-prediluted-ab124486.html", "date": "2017-02-20T23:00:34Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-09/segments/1487501170613.8/warc/CC-MAIN-20170219104610-00182-ip-10-171-10-108.ec2.internal.warc.gz", "language_score": 0.6863343119621277, "token_count": 405, "dump": "CC-MAIN-2017-09", "global_id": "webtext-fineweb__CC-MAIN-2017-09__0__93770729", "lang": "en", "text": "- 存放说明Shipped at 4°C. Store at +4°C.\n- 存储溶液pH: 7.40\nPreservative: 0.05% Sodium azide\nConstituent: 1% BSA\nNote: The Prediluted antibody is supplied in our Universal antibody dilution buffer (AR-6526) green in color(NaCl 1.2%,Tris Hcl 0.3%,Proclin 3 0.05%,Triton X 100 0.025%,Green color(food) 0.01%,H2o 98%,carrier protein(proprietary)0.5%\nConcentration information loading...\n- 纯度Protein A purified\nOur Abpromise guarantee covers the use of\nin the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\n- 功能Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.\n- 疾病相关Amyloidosis 8\n- 序列相似性Belongs to the glycosyl hydrolase 22 family.\nInformation by UniProt\n- 1 4 beta N acetylmuramidase C antibody\n- 1 antibody\n- 4-beta-N-acetylmuramidase C antibody\nAnti-Lysozyme antibody, prediluted (ab124486)参考文献\nhas not yet been referenced specifically in any publications.\nPlease note: All products are \"FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE\"", "domain": "chemistry", "round": 3} +{"url": "https://www.matec-conferences.org/articles/matecconf/abs/2019/47/matecconf_icmtmte18_00088/matecconf_icmtmte18_00088.html", "date": "2020-08-05T14:08:36Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-34/segments/1596439735958.84/warc/CC-MAIN-20200805124104-20200805154104-00031.warc.gz", "language_score": 0.8266316056251526, "token_count": 356, "dump": "CC-MAIN-2020-34", "global_id": "webtext-fineweb__CC-MAIN-2020-34__0__84272588", "lang": "en", "text": "MATEC Web Conf.\nVolume 298, 2019International Conference on Modern Trends in Manufacturing Technologies and Equipment: Mechanical Engineering and Materials Science (ICMTMTE 2019)\n|Number of page(s)||6|\n|Published online||18 November 2019|\nFormation of Cr-Zr gradient layer by magnetron sputtering and ion mixing\nNational Research Tomsk Polytechnic University, 30 av. Lenin, Tomsk, 634050, Russia\n* Corresponding author: firstname.lastname@example.org\nThe gradient Cr-Zr layer was formed onto Zr-1Nb substrate by magnetron sputtering of chromium and zirconium targets and ion mixing (Ar+ with 25 keV). The distribution of Cr and Zr elements in the deposited coatings was measured by using a glow discharge optical emission spectroscopy. The optimal ion fluence onto the substrate was 8×1019 ion/m2. At higher ion dose, the intensive sputtering of the deposited coating was observed.\n© The Authors, published by EDP Sciences, 2019\nThis is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.\nCurrent usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.\nData correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.\nInitial download of the metrics may take a while.", "domain": "chemistry", "round": 3} +{"url": "https://citationsy.com/archives/q?doi=10.1152/AJPHEART.00785.2002", "date": "2021-10-21T03:23:12Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-43/segments/1634323585380.70/warc/CC-MAIN-20211021005314-20211021035314-00282.warc.gz", "language_score": 0.8662490248680115, "token_count": 271, "dump": "CC-MAIN-2021-43", "global_id": "webtext-fineweb__CC-MAIN-2021-43__0__181893655", "lang": "en", "text": "Modulation Of Mitochondrial Nitric Oxide Synthase And Energy Expenditure In Rats During Cold Acclimation\nTo preserve thermoneutrality, cold exposure is followed by changes in energy expenditure and basal metabolic rate (BMR). Because nitric oxide (NO) modulates mitochondrial O2 uptake and energy levels, we analyzed cold effects (30 days at 4°C) on rat liver and skeletal muscle mitochondrial NO synthases (mtNOS) and their putative impact on BMR. Cold exposure delimited two periods: A ( days 1–10), with high systemic O2 uptake and weight loss, and B ( days 10–30), with lower O2 uptake and fat deposition. mtNOS activity and expression decreased in period A and then increased in period B by 60–100% in liver and skeletal muscle ( P< 0.05). Conversely, mitochondrial O2 uptake remained initially high in the presence of l-arginine and later fell by 30–50% ( P < 0.05). On this basis, the estimated fractional contribution of liver plus muscle to total BMR varied from 40% in period A to 25% in period B. The transitional modulation of mtNOS in rat cold acclimation could participate in adaptive responses that favor calorigenesis or conservative energy-saving mechanisms.", "domain": "chemistry", "round": 3} +{"url": "https://meridian.allenpress.com/radiation-research/article-abstract/44/1/24/44823/Radical-Distributions-in-Irradiated-Dry-Proteins?redirectedFrom=fulltext", "date": "2021-02-28T03:44:52Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-10/segments/1614178360107.7/warc/CC-MAIN-20210228024418-20210228054418-00216.warc.gz", "language_score": 0.7637917399406433, "token_count": 646, "dump": "CC-MAIN-2021-10", "global_id": "webtext-fineweb__CC-MAIN-2021-10__0__169075354", "lang": "en", "text": "Gamma radiolysis of dry proteins at 195°K in the presence of tritiated hydrogen sulfide gives information about the distribution of carbon radicals which are precursors of the secondary radicals observed at 298°K. When lyophilized ribonuclease, lysozyme, chymotrypsinogen, and nagarse (a protein without disulfide bridges) are irradiated at 195°K, the observed tritium distributions are approximately equivalent; however, at 298°K characteristic distributions are found. Thus, the mechanisms for the formation of carbon radicals in native proteins can be divided into two groups: first, those which take place below 195°K and are independent of amino acid sequence, conformation, and the presence of disulfide bridges; and second, those which occur above 195°K and are influenced by the specific conformation of each native protein.\nSkip Nav Destination\nResearch Article| October 01 1970\nRadical Distributions in γ-Irradiated Dry Proteins at 195°K\nRadiat Res (1970) 44 (1): 24–34.\n- Views Icon Views\n- Share Icon Share\n- Search Site\nP. Riesz, F. H. White,; Radical Distributions in γ-Irradiated Dry Proteins at 195°K. Radiat Res 1 October 1970; 44 (1): 24–34. doi: https://doi.org/10.2307/3573168\nDownload citation file:\nCiting articles via\nCommonalities Between COVID-19 and Radiation Injury\nCarmen I. Rios, David R. Cassatt, Brynn A. Hollingsworth, Merriline M. Satyamitra, Yeabsera S. Tadesse, Lanyn P. Taliaferro, Thomas A. Winters, Andrea L. DiCarlo\nLow-Dose Radiation Therapy (LDRT) for COVID-19: Benefits or Risks?\nPataje G. Prasanna, Gayle E. Woloschak, Andrea L. DiCarlo, Jeffrey C. Buchsbaum, Dörthe Schaue, Arnab Chakravarti, Francis A. Cucinotta, Silvia C. Formenti, Chandan Guha, Dale J. Hu, Mohammad K. Khan, David G. Kirsch, Sunil Krishnan, Wolfgang W. Leitner, Brian Marples, William McBride, Minesh P. Mehta, Shahin Rafii, Elad Sharon, Julie M. Sullivan, Ralph R. Weichselbaum, Mansoor M. Ahmed, Bhadrasain Vikram, C. Norman Coleman, Kathryn D. Held\nGermicidal Efficacy and Mammalian Skin Safety of 222-nm UV Light\nManuela Buonanno, Brian Ponnaiya, David Welch, Milda Stanislauskas, Gerhard Randers-Pehrson, Lubomir Smilenov, Franklin D. Lowy, David M. Owens, David J. Brenner", "domain": "chemistry", "round": 3} +{"url": "https://m.scirp.org/papers/33884", "date": "2020-01-26T01:59:54Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-05/segments/1579251684146.65/warc/CC-MAIN-20200126013015-20200126043015-00447.warc.gz", "language_score": 0.715614914894104, "token_count": 1339, "dump": "CC-MAIN-2020-05", "global_id": "webtext-fineweb__CC-MAIN-2020-05__0__149987032", "lang": "en", "text": "Purebred microorganisms were employed to upgrade the fermentation process of Zhejiang rosy vinegar. The fermentation cycle was greatly shorten from 5 months to 72 d. The transformation rate of raw materials was increased from 1:4.5 in the traditional fermentation to 1:5 or more in the upgraded fermentation. The content of organic acids in the traditional vinegar (TRV), the upgraded vinegar (UPV) and the submerged fermentation vinegar (SFV) were also investigated by HPLC. No significant difference was found regarding the proportion of phenylethanol to the total volatile components in UPV (7.47%±0.00324%) and TRV (7.23%±0.00329%), but it was significantly higher than that in SFV (2.26%±0.00143%). This study provides deep insight into upgrading the fermentation process of Zhejiang rosy vinegar bypurebred microorganisms.\nCite this paper\nY. Jiang, S. Lin, L. Zhang and P. Yu, \"Upgrading the Fermentation Process of Zhejiang Rosy Vinegar by Purebred Microorganisms,\" Advances in Microbiology, Vol. 3 No. 3, 2013, pp. 297-301. doi: 10.4236/aim.2013.33042.\n L. Giordano, R. Calabrese, E. Davoli and D. Rotilia, “Quantitive Analysis of 2-Furfural and 5-Methylfurfural in Different Italian Vinegar by Headspace Solid-Phase Microextraction Coupled to Gas Chromatography-Mass Spectrometry Using Isotope Dilution,” Journal of Chromatography A, Vol. 1017, No. 1-2, 2003, pp. 141-149.\n W. Tesfaye, M. L. Morales, M. C. Garca-Parrilla and A. M. Troncoso, “Wine Vinegar: Technology, Authenticity and Quality Evaluation,” Trends in Food Science and Technology, Vol. 13, No. 1, 2002, pp. 12-21.\n J. G. Wang, “Preliminary Study on the Traditional Technology of Zhejiang Rosy Vinegar,” China Brewing, Vol. 6, No. 5, 2004, pp. 23-26.\n W. P. Hammes, M. J. Brandt, K. L. Francis, J. Rosenheim, M. F. H. Seitter and S. A. Vogelmann, “Microbial Ecology of Cereal Fermentations,” Trends in Food Science and Technology, Vol. 16, No. 1-3, 2005, pp. 4-11.\n S. Haruta, S. Ueno, I. Egawa, K. Hashiguchi, A. Fujii, M. Nagano, M. Ishii and Y. Igarashi, “Succession of Bacterial and Fungal Communities during a Traditional Pot Fermentation of Rice Vinegar Assessed by PCR-Mediated Denaturing Gradient Gel Electrophoresis,” International Journal of Food Microbiology, Vol. 109, No. 1-2, 2006, pp. 79-87. doi:10.1016/j.ijfoodmicro.2006.01.015\n F. López, P. Pescador, C. Guell, M. L. Morales, M. C. García-Parrilla and A. M. Troncoso, “Industrial Vinegar Clarification by Cross-Flow Microfiltration: Effect on Colour and Polyphenol Content,” Journal of Food Engineering, Vol. 68, No. 1, 2005, pp. 133-136.\n M. Cocchi, C. Durante, G. Foca, D. Manzini, A. Marchetti and A. Ulrici, “Application of a Wavelet-Based Algorithm on HS-SPME/GC Signals for the Classification of Balsamic Vinegars,” Chemometrics and Intelligent Laboratory Systems, Vol. 71, No. 2, 2004, pp. 129-140.\n M. Cocchi, C. Durante, M. Grandi, P. Lambertini, D. Manzini and A. Marchetti, “Simultaneous Determination of Sugars and Organic Acids in Aged Vinegars and Chemometric Data Analysis,” Talanta, Vol. 69, No. 5, 2006, pp. 1166-1175. doi:10.1016/j.talanta.2005.12.032\n C. Pizarro, I. Esteban-Diez and C. Saenz-Gonzalez, “Vinegar Classfication Based on Feature Extraction and Selection from Headspace Solid-Phase Microextraction/Gas Chromatography Volatile Analysises: A Feasibility Study,” Analytica Chimica Acta, Vol. 608, No. 1, 2008, pp. 38-47. doi:10.1016/j.aca.2007.12.006\n M. J. Sáiz-Abajo, J. M. González-Sáiz and C. Pizarro, “Multi-Objective Optimisation Strategy Based on Desirability Functions Used for Chromatographic Separation and Quantification of L-Proline and Organic Acids in Vinegar,” Analytica Chimica Acta, Vol. 528, No. 1, 2005, pp. 63-76. doi:10.1016/j.aca.2004.06.027\n M. J. Sáiz-Abajo, J. M. González-Sáiz and C. Pizarro, “Prediction of Organic Acids and Other Quality Parameters of Wine Vinegar by Near-Infrared Spectroscopy. A Feasibility Study,” Food Chemistry, Vol. 99, No. 3, 2006, pp. 615-621. doi:10.1016/j.foodchem.2005.08.006\n H. Song and K. R. Cadwallader, “Aroma Components of American Country Ham,” Journal of Food Science, Vol. 73, No. 1, 2008, pp. c29-c35.", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/hnrnpul2-antibody-ab220849.html", "date": "2020-10-25T16:05:57Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-45/segments/1603107889574.66/warc/CC-MAIN-20201025154704-20201025184704-00269.warc.gz", "language_score": 0.6836583614349365, "token_count": 297, "dump": "CC-MAIN-2020-45", "global_id": "webtext-fineweb__CC-MAIN-2020-45__0__158771855", "lang": "en", "text": "Key features and details\n- Rabbit polyclonal to HNRNPUL2\n- Suitable for: ICC/IF\n- Reacts with: Human\n- Isotype: IgG\nStorage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.\nStorage bufferpH: 7.20\nPreservative: 0.02% Sodium azide\nConstituents: 59% PBS, 40% Glycerol (glycerin, glycerine)\nConcentration information loading...\nPurityImmunogen affinity purified\nOur Abpromise guarantee covers the use of ab220849 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\n|ICC/IF||Use a concentration of 0.25 - 2 µg/ml.|\nSequence similaritiesContains 1 B30.2/SPRY domain.\nContains 1 SAP domain.\n- Information by UniProt\n- DKFZp762N1910 antibody\n- Heterogeneous nuclear ribonucleoprotein U like 2 antibody\n- Heterogeneous nuclear ribonucleoprotein U like protein 2 antibody\nab220849 has not yet been referenced specifically in any publications.", "domain": "chemistry", "round": 3} +{"url": "https://www.ck2inhibitor.com/2023/02/23/8138/", "date": "2024-04-23T07:25:21Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712296818468.34/warc/CC-MAIN-20240423064231-20240423094231-00653.warc.gz", "language_score": 0.9445675611495972, "token_count": 777, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__18945431", "lang": "en", "text": "E cells and hence suppress inflammation . Lipid cyclization goods could also be involved in inflammatory reactions, and no less than a number of the effects of isoprostanes are on account of their chemical similarity with prostaglandins; therefore, isoprostanes may perhaps also act by way of prostaglandin receptors . It has been shown that 8-isoPGE2 and 8-isoPGF2 enhance the interactions amongst endothelial cells, macrophages, and neutrophils and thus raise migration of those cells to the web site of inflammation [143,144]. Additionally, 8-isoPGF2 can activate the MAPK pathway in macrophages causing higher production of IL-8 inside the cells . Because IL-8 is very important within the differentiation of lymphocytes into Th1 cells, 8-isoPGF2 may enhance inflammation in autoimmune ailments . In contrast, isoprostanes can also act as anti-inflammatory agents by reacting with cysteine residues in IB kinase (IKK). Usually, IKK phosphorylates NF-B inhibitors, top to their conjugation with ubiquitin and subsequent degradation and resulting in activation of NF-B . However, due to the fact 15-A2-isoprostanes interfere with this course of action, they cause decrease activation of NF-B . Larger levels of isoprostanes happen to be observed in most autoimmune illnesses which includes psoriasis, SLE, RA, and in other conditions which can be accompanied by oxidative anxiety [33,140,141]. Despite the fact that isoprostanes may perhaps play a part in modulation of immune cell function, they may be so far mostly regarded to be markers of oxidative stress, with their effect believed to become less significant than the effect of other lipid derivatives in the case of immunity. This situation once again shows two faces of ROS and induced by them the oxidative strain and its effects, in this case an increase inside the level of isoprostanes. A comparable response was generated by the effects of dimethylformamide (DMF)pharmacotherapy for various sclerosis , manifested by an increase in ROS production, which was thought of to manage the dysregulated autoimmune response of monocytes. IP Inhibitor Storage & Stability Presumably, a equivalent situation applies to other autoimmune ailments, which include these that are the concentrate of this evaluation.Int. J. Mol. Sci. 2021, 22,14 of2. Conclusions It might be assumed that oxidative stress that accompanies autoimmune diseases might intensify inflammation. Furthermore, there is certainly ample evidence that reactive oxygen species (ROS) increases inflammation and activates immune cells. The goods of ROS-dependent lipid metabolism are also usually deemed as pro-inflammatory agents and are observed at larger levels in autoimmune ailments. The scenario is a lot more complicated for enzymatic lipid metabolism products as a few of these may possibly act as pro-inflammatory aspects, while other folks as anti-inflammatory ones . Additionally, it seems that endocannabinoids can act in two directions depending on which receptor they activate; on the other hand, for the reason that CB2 receptors predominate in immune cells and most studies show that endocannabinoids minimize immune cell activity, enhanced endocannabinoid production in autoimmune ailments is usually thought of as a compensatory mechanism that at least partially reduces inflammation. Probably probably the most perplexing predicament is with eicosanoids, which are in element anti-inflammatory HDAC2 Inhibitor Compound factors and raise differentiation of lymphocytes to Th2, whilst they are likely essential for the development of both Th1 and Th2 responses. Despite this, complicated interactions amongst lipids and also the immune method are intensified for the duration of autoimmune dis.", "domain": "chemistry", "round": 3} +{"url": "http://www.sas.upenn.edu/rappegroup/index.html", "date": "2016-02-13T12:55:27Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2016-07/segments/1454701166650.78/warc/CC-MAIN-20160205193926-00057-ip-10-236-182-209.ec2.internal.warc.gz", "language_score": 0.771344780921936, "token_count": 1051, "dump": "CC-MAIN-2016-07", "global_id": "webtext-fineweb__CC-MAIN-2016-07__0__136263033", "lang": "en", "text": "The Rappe Group engages in theoretical investigation to explain and predict the properties of a broad spectrum of fascinating chemical systems, from small molecules to complex lattices.\nRelaxor ferroelectrics have fascinating physical properties exhibitting a stronger piezoelectric effect, a high permittivity value over a broad temperature range, and a strong frequency disperion in dielectric response. Recently we found local dynamics induced by interaction through sharing oxygen atoms in 0.74PbMg1/3Nb2/3O3-0.25PbTiO3, a known relaxor. This transition is analogous to water which exhibits unique dielectric response similar to relaxors. Read more about it from: H. Takenaka, I. Grinberg, and A. M. Rappe, \"Anisotropic local correlations and dynamics in a relaxor ferroelectric\", Phys. Rev. Lett. 110, 147602 (1-5) (2013).\nPure spin current means that \"up\" spin and \"down\" spin move in opposite directions with same magnitude and the total charge current will be zero. Bulk Photovoltaic pure spin current in antiferromagnetics originates from mirror symmetry of two sublattices with different spins. Without strongly spin-orbital coupling or circular light, it can generate pure spin current. Read more about it from: S. M. Young, F. Zheng, and A. M. Rappe, \"Prediction of a linear spin bulk photovoltaic effect in antiferromagnets\", Phys. Rev. Lett. 110, 057201 (1-4) (2013).\nAn atomictic potential for BiFeO3 based on bond-valence and bond-valence vector conservation has been developed. The model reproduces the ferroelectric -to-paraelectric phase trasition in both constant volume and pressure MD simulations. Read more about it from: S. Liu, I. Grinberg, and A. M. Rappe, \"Development of a bond-valence based interatomic potential for BiFeO3 for accurate molecular dynamics simulations\", J. Phys. Cond. Matt. 25, 102202 (1-6) (2013).\nGroup meetings are currently held on Tuesdays 1:30 pm at the Theory Conference room (141E)\nPhysical Chemistry Seminars at Penn Chemistry (Thursdays 1:00pm Carolyn Lynch Lecture Hall)\nY. Kim, B. J. Wieder, C. L. Kane, and A. M. Rappe, \"Dirac Line Nodes in Inversion-Symmetric Crystals\" Phys. Rev. Lett., 115, 036806 (2015) PDF\nY. Qi, J. M. P. Martirez, Wissam A. Saidi, J. J. Urban, W. S. Yun, J. E. Spanier, and A. M. Rappe, \"Modified Schottky Emission to Explain Thickness Dependence and Slow Depolarization in BaTiO3 Nanowires\" Phys. Rev. B, 91, 245431 (2015) PDF\nF. Wang , and A. M. Rappe, \"First-principles calculation of the bulk photovoltaic effect in KNbO3 and (K,Ba)(Ni,Nb)O3-δ\" Phys. Rev. B, 91, 165124 (2015) PDF\nJ. M. P. Martirez , S. Kim , E. H. Morales B. T. Diroll, M. Cargnello, T. R. Gordon ,C. B. Murray , D. A. Bonnell , and A. M. Rappe, \"Synergistic Oxygen Evolving Activity of a TiO2 Rich Reconstructed SrTiO3 (001) Surface\" J. Am. Chem. Soc. ASAP (2015) PDF\nS. Liu, F. Zheng, N. Z. Koocher, H. Takenaka, F. Wang, and A. M. Rappe, \"Ferroelectric Domain Wall Induced Band Gap Reduction and Charge Separation in Organometal Halide Perovskite\" J. Phys. Chem. Lett. 6, 693 (2015) PDF\nN. Moghadam, S. Liu, S. Srinivasan, M. C. Grady, A. M. Rappe, and M. Soroush, \"Theoretical Study of Intermolecular Chain Transfer to Polymer Reactions of Alkyl Acrylates\" Ind. Eng. Chem. Res. ASAP (2015) PDF\nC. Baeumer, D. Saldana-Greco, J. M. P. Martirez, A. M. Rappe, M. Shim, and L. W. Martin, \"Ferroelectrically driven spatial carrier density modulation in graphene\" Nat. Commun. 6:6136 (2015) PDF", "domain": "chemistry", "round": 3} +{"url": "https://morettomotorsportz.com/power-steering-fluid-brands/", "date": "2020-07-08T14:12:19Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-29/segments/1593655897027.14/warc/CC-MAIN-20200708124912-20200708154912-00575.warc.gz", "language_score": 0.9559553861618042, "token_count": 841, "dump": "CC-MAIN-2020-29", "global_id": "webtext-fineweb__CC-MAIN-2020-29__0__132585783", "lang": "en", "text": "You should also do a regular check of your power steering fluid. You need to make sure that your car has enough of it to keep running smoothly. You should also check your car’s power systems and be on the lookout for leakages. Plenty of car engines have transparent reservoirs so spotting holes and leaks shouldn’t be so hard.\nA GOOD POWER STEERING FLUID ALTERNATIVE\nChoosing a substitute for power steering fluid is not easy. You have to be very careful because putting the wrong kind of liquid in your car will cost you so much money in repairs. The wrong power steering fluid alternative will destroy your car’s rubber and plastic parts. It might even cause a terrible chemical reaction when it mixes with your car’s original fluids.\nNot all cars use the same power steering fluid. While most go for mineral oil or those silicone based-ones, others use ATF. The difference is that ATF is created using synthetic elements. You need to keep that in mind when choosing a power steering fluid substitute. There are many fluids out there and not all of them will work with your vehicle. So choose wisely.\nWhat are your options?\nYou need to understand what kind of fluid you need before buying anything. Not every car fluid will word for your power system. For example, can you use brake fluids as a power steering fluid substitute? The answer is no. They’re not made of the same components and would affect your car differently.\nBrake fluids are a mixture of many chemicals, but they’re mainly made up of glycol-ether made fluids. While ATF, the common power steering fluid substitute, is made up of 80-90 percent synthetic base oil and the rest of it are additives.\nThis is why it’s important to be critical when choosing the compatible fluid. All these fluids are made up of different things. The wrong choice can do major damage to your vehicle.\nThe most common power steering fluid alternatives are made by gas companies. Even if they’re all ATF, they all have different recipes. Some have higher viscosity and additives than others. You need to know, which will work for your vehicle before choosing which one to get.\nThe best ATFs on the market\nHere are the top substitutes that you can use for your vehicle.\nDexron power steering fluid\nThe Dexron power steering fluid has been on the market for a while. It used to be a greenish, brownish substance until sperm what oils were banned from the market. Since it was the main ingredient to making this steering fluid, its entire recipe needed reformulating. Don’t worry, the new fluid is just as efficient as the one before. Dexron currently has many different variations like Dexron IIE, Dexron III G, etc.\nMercon power steering fluid\nThis other power steering fluid substitute also has different variations like Mercon H, Mercon V, etc.\nDexron and Mercon are interchangeable. These two fluids are so common that car companies have adapted them for their vehicles. There are many kinds of them on the market, so be careful when getting the right one for your ride.\nSome gas companies guarantee that these products can be used for many different types of engines. This is not exactly true. You should be careful of fluids that claim to work for plenty of vehicles.\nOther types of Automatic Transmission Fluids\nThis atf power steering fluid was made during the 50s. It was the only fluid around then, and it was used for all types of motors. It was on the market up until the 60s.\nThis is another old type atf power steering fluid it can now only be used for antique cars.\nHFM(Highly friction modified) Fluids\nThis ATF has more friction than both Mercon and Dexron.\nIn case of emergency go for ATFs. They’re your safest bet at getting your car back to life. However, nothing can replace the real thing. Power Steering fluids are budget friendly. No substitute can power your engine better than they can.", "domain": "chemistry", "round": 3} +{"url": "https://www.powtech.de/de/ausstellerprodukte/powtec19/produkt-10159945/particle-size-and-particle-shape-analysis", "date": "2021-06-19T06:42:12Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-25/segments/1623487643703.56/warc/CC-MAIN-20210619051239-20210619081239-00548.warc.gz", "language_score": 0.6846853494644165, "token_count": 722, "dump": "CC-MAIN-2021-25", "global_id": "webtext-fineweb__CC-MAIN-2021-25__0__69290804", "lang": "en", "text": "Wir möchten auf unserer Internetseite Dienste von Drittanbietern nutzen, die uns helfen, unsere Werbeangebote zu verbessern (Marketing), die Nutzungsweise unserer Internetseite auszuwerten (Performance) und die Internetseite an Ihre Vorlieben anzupassen (Funktional). Für den Einsatz dieser Dienste benötigen wir Ihre Einwilligung, welche jederzeit widerrufen werden kann. Informationen zu den Diensten und eine Widerspruchsmöglichkeit finden Sie unter „Benutzerdefiniert“. Weitergehende Informationen finden Sie in unserer Datenschutzerklärung.\nParticle size and size distribution are important physical characteristics for the quality of products and highly influence the behavior during processing and handling of powders, like flowability, transport and storage. Laboratory particle sizing analysis by characterization of size distribution and shape is a strong tool in R&D and Quality Control environment.\nClosely related to particle sizing analysis is the droplet size distribution of sprays, nebulizers and other aerosols. Droplet size analysis is mainly used to optimize nozzle design, enhance inkjet printing technology, restrict excessive use of pesticides and increase medicine effectiveness.\nObviously, sieving is the best-known classical approach to fractionate materials and determine particle size distributions. Currently, various modern techniques such as Laser Diffraction (light scattering or laser scattering), Photon Correlation Spectroscopy (PCS), Electrical Sensing Zone, Image Analysis, Laser Doppler Velocimetry and Microscopy (electron microscopy and optical microscopy) are available for sizing analysis. These techniques are offered in our laboratory, besides more conventional particle sizing methods such as Andreasen (Sedimentation) and Sieve Analysis.\nOur laboratory uses equipment from the following manufacturers for particle size analysis: Malvern, Beckman Coulter, and Micromeritics.\nLeider gibt es für diesen Aussteller kein deutsches Firmenprofil.\nDelft Solids Solutions is a contract research organisation founded in 2002. Our core activities are focused on a better understanding of processes in which powders and solids are used. A more detailed description of materials properties on the micro-level leads to an improved understanding of the behaviour and control of solids on the macro-level. To this end, we employ a variety of experimental set-ups in our laboratory and test areas.\nA broad range of methodologies and techniques including method development and consulting is available. Correlating more fundamental parameters such as particle size, porosity, and surface area with bulk solids behavior – flowability, attrition, shear, dustiness of powders – enables to establish firm links with theory and practice. Areas we are active in include, but are not limited to: pharmaceutical materials, medical devices, building materials, catalysts, filler materials, pigments, food and food additives, and handling of bulk solids in general. Delft Solids Solutions can help you to enhance the quality of your process and product by an improved understanding. Our most recent expansion of portfolio includes the assessment of nano-properties of products, in line with upcoming regulations and ordinances. Are you nano-proof?", "domain": "chemistry", "round": 3} +{"url": "https://umexpert.um.edu.my/sujatha", "date": "2017-12-18T14:35:04Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-51/segments/1512948617816.91/warc/CC-MAIN-20171218141805-20171218163805-00579.warc.gz", "language_score": 0.6777859330177307, "token_count": 255, "dump": "CC-MAIN-2017-51", "global_id": "webtext-fineweb__CC-MAIN-2017-51__0__232913579", "lang": "en", "text": "Dr. Sujatha A/p Ramasamy\nInstitute Of Biological Sciences\nFaculty Of Sciencesujatha@um.edu.my\n|This information is generated from Research Grant Management System|\nChemical constituents from Walsura pinnata (Meliaceae)\nBioactivity and Stability Studies of Anthocyanin- Containing Extracts from Garcinia mangostana L. and Etlingera elatior Jack\nEffect of extracts from Phyllanthus watsonii Airy Shaw on cell apoptosis in cultured human breast cancer MCF-7 cells\nGrowth Inhibition of Human Gynecologic and Colon Cancer Cells by Phyllanthus watsonii through Apoptosis Induction\nMedicinal properties of the edible mushroom Pleurotus sajor-caju.\nMedicinal Properties of Selected Pleurotus spp. cultivated in Malaysia.\nAntagonistic Micromonospora isolates from mangrove rhizospheres soil of Malaysia.\nBiological and Molecular characterization of antagonistic Micromonospora strain M39 isolated from Malaysian mangrove rhizosphere soil.\nAntagonistic Micromonospora Isolates from Mangrove Rhizospheres", "domain": "chemistry", "round": 3} +{"url": "https://www.routledge.com/Advanced-Ceramic-Membranes-and-Applications/Das-Bose/p/book/9780367573188", "date": "2022-01-28T09:03:44Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-05/segments/1642320305423.58/warc/CC-MAIN-20220128074016-20220128104016-00243.warc.gz", "language_score": 0.8707262277603149, "token_count": 293, "dump": "CC-MAIN-2022-05", "global_id": "webtext-fineweb__CC-MAIN-2022-05__0__197197774", "lang": "en", "text": "This book provides a balanced blend of fundamental concepts of fabrication, characterization of conventional ceramics, extending to present the recent advances in ceramic membranes. It covers the basic concepts of ceramic membranes as well as practical and theoretical knowledge in conventional and advanced ceramic membranes combined with unorthodox ideas for novel approaches in ceramic membranes. Book includes lot of real time examples derived largely from research work by authors. Aimed at researchers, students and academics in the field of membrane engineering around the globe, it has following key features:\n- Guides readers through manufacturing, characterizing and using low-cost ceramic technology.\n- Provides an overview of the different types of ceramic membranes, catalytic reactors and their uses.\n- Covers industrial application, separation and purification.\n- Includes recent developments and advances in membrane fabrication.\n- Discusses new raw materials for ceramic membranes.\nTable of Contents\n1. Ceramic Membrane Processes\n2. Fabrication of Ceramic Membranes\n3. Characterization Techniques\n4. Ceramic Membrane Cleaning Methods\n5. Introduction to Membrane Reactors and Membrane Contactors\n6. Low-Cost Tubular Ceramic Support Membranes\n7. Fabrication of a Low-Cost Tubular Catalytic Membrane Reactor\n8. Study of Mass Transfer of CMRs\n9. Various Applications of Ceramic Membranes", "domain": "chemistry", "round": 3} +{"url": "http://www.mdpi.com/1420-3049/22/1/61", "date": "2018-03-24T16:23:28Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-13/segments/1521257650730.61/warc/CC-MAIN-20180324151847-20180324171847-00547.warc.gz", "language_score": 0.8808102607727051, "token_count": 524, "dump": "CC-MAIN-2018-13", "global_id": "webtext-fineweb__CC-MAIN-2018-13__0__87226829", "lang": "en", "text": "Comparison of Hydrogels Based on Commercial Chitosan and Beetosan® Containing Nanosilver\nAbstractTwo series of hydrogels on the basis of commercial chitosan and chitosan derived from naturally expired honeybees are presented in this article. Sorption capacity and behavior of both kind of materials in simulated body fluids such as Ringer’s liquid or artificial saliva have been determined and compared. Presence of functional groups in synthesized materials have been determined by means of FT-IR spectroscopy. Structure and homogeneity of their surface have been defined using Scanning Electron Microscopy. Based on the conducted research, it can be stated that both chitosan and Beetosan® hydrogels have very similar characteristics. It is worth noting that synthesis of such materials is environmentally friendly and leads to obtaining polymers that can be used for biomedical applications. Tested materials are characterized by low sorption capacity and do not have a negative impact on simulated body fluids. Moreover, based on the cell lines studies, it can be stated that Beetosan® hydrogels have a negative influence on cells of cancerous origin and, what is important, significantly less adverse effects on fibroblasts. View Full-Text\nScifeed alert for new publicationsNever miss any articles matching your research from any publisher\n- Get alerts for new papers matching your research\n- Find out the new papers from selected authors\n- Updated daily for 49'000+ journals and 6000+ publishers\n- Define your Scifeed now\nTyliszczak, B.; Drabczyk, A.; Kudłacik, S. Comparison of Hydrogels Based on Commercial Chitosan and Beetosan® Containing Nanosilver. Molecules 2017, 22, 61.\nTyliszczak B, Drabczyk A, Kudłacik S. Comparison of Hydrogels Based on Commercial Chitosan and Beetosan® Containing Nanosilver. Molecules. 2017; 22(1):61.Chicago/Turabian Style\nTyliszczak, Bożena; Drabczyk, Anna; Kudłacik, Sonia. 2017. \"Comparison of Hydrogels Based on Commercial Chitosan and Beetosan® Containing Nanosilver.\" Molecules 22, no. 1: 61.\nNote that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.", "domain": "chemistry", "round": 3} +{"url": "http://www.abcam.com/BAAT1-antibody-ab84362.html", "date": "2013-12-07T11:07:37Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2013-48/segments/1386163054096/warc/CC-MAIN-20131204131734-00092-ip-10-33-133-15.ec2.internal.warc.gz", "language_score": 0.776268482208252, "token_count": 688, "dump": "CC-MAIN-2013-48", "global_id": "webtext-fineweb__CC-MAIN-2013-48__0__189500108", "lang": "en", "text": "Anti-BAAT1 antibody (ab84362)\n- Product nameAnti-BAAT1 antibodySee all BAAT1 primary antibodies ...\n- DescriptionRabbit polyclonal to BAAT1\n- Tested applicationsIHC-P more details\n- Species reactivityReacts with: Human\nPredicted to work with: Chimpanzee, Rhesus monkey, Gorilla, Orangutan\nSynthetic peptide corresponding to a region between residues residue 775 and the C terminus (residue 821) of Human BAAT1 (accession number: NP_689956.1)\n- Positive control\n- Human metastatic lymph node; Human lung non small cell cancer\n- Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.\n- Storage bufferPreservative: 0.09% Sodium Azide\nConstituents: 0.1% BSA, Tris buffered saline\n- Concentration information loading...\n- PurityImmunogen affinity purified\n- Purification notesPurified using an epitope specific to BAAT1 immobilized on solid support.\n- Clonality Polyclonal\n- Research Areas\nOur Abpromise guarantee covers the use of ab84362 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\nNot yet tested in other applications.\nOptimal dilutions/concentrations should be determined by the end user.\n- FunctionRequired for activation of ATM following ionizing radiation. May act by regulating dephosphorylation of ATM.\n- Tissue specificityUbiquitously expressed.\n- Sequence similaritiesContains 2 HEAT repeats.\n- Cellular localizationNucleus. Present at double strand breaks (DSBs) following ionizing radiation treatment.\n- BAAT 1 antibody\n- BAAT1 antibody\n- BRAT 1 antibody\n- brat1 antibody\n- BRAT1_HUMAN antibody\n- BRCA1-associated ATM activator 1 antibody\n- BRCA1-associated protein required for ATM activation protein 1 antibody\n- BRCA1-associated protein required for ATM activation-1 antibody\n- C7orf27 antibody\n- chromosome 7 open reading frame 27 antibody\n- HEAT repeat containing protein C7orf27 antibody\n- MGC22916 antibody\nAnti-BAAT1 antibody images\nDetection of Human BAAT1 in formalin-fixed paraffin-embedded section of Human metastatic lymph node by Immunohistochemistry using ab84362 at a dilution of 1/250. Detection was performed by DAB staining using anti-Rabbit IHC antibody at a dilution of 1/100.\nDetection of Human BAAT1 in formalin-fixed paraffin-embedded section of Human lung non-small cell cancer by Immunohistochemistry using ab84362 at a dilution of 1/250. Detection was performed by DAB staining using anti-Rabbit IHC antibody at a dilution of 1/100.\nReferences for Anti-BAAT1 antibody (ab84362)\nab84362 has not yet been referenced specifically in any publications.", "domain": "chemistry", "round": 3} +{"url": "https://pubmed.ncbi.nlm.nih.gov/9280070/?dopt=Abstract", "date": "2020-09-22T02:29:07Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-40/segments/1600400202686.56/warc/CC-MAIN-20200922000730-20200922030730-00364.warc.gz", "language_score": 0.9176175594329834, "token_count": 462, "dump": "CC-MAIN-2020-40", "global_id": "webtext-fineweb__CC-MAIN-2020-40__0__274837648", "lang": "en", "text": "The(1) regulatory mechanism of glucose uptake in 3T3-L1 adipocytes was investigated with the use of recombinant adenovirus vectors encoding various dominant negative proteins. Infection with a virus encoding a mutant regulatory subunit of phosphoinositide (PI) 3-kinase that does not bind the 110-kDa catalytic subunit (delta p85) inhibited the insulin-induced increase in PI 3-kinase activity co-precipitated by antibodies to phosphotyrosine and glucose uptake in a virus dose-dependent manner. Overexpression of a dominant negative RAS mutant in which Asp57 is replaced with tyrosine (RAS57Y) or of a dominant negative SOS mutant that lacks guanine nucleotide exchange activity (delta SOS) abolished the insulin-induced increase in mitogen-activated protein kinase activity, but had no effect on PI 3-kinase activity or glucose uptake. Although GH and hyperosmolarity attributable to 300 mM sorbitol each promoted glucose uptake and translocation of glucose transporter (GLUT)4 to an extent comparable to that of insulin, these stimuli triggered little or no association of PI 3-kinase activity with tyrosine-phosphorylated proteins. Overexpression of delta p85 or treatment of cells with wortmannin, an inhibitor of PI 3-kinase activity, had no effect on glucose uptake or translocation of GLUT4 stimulated by GH or hyperosmolarity. Moreover, overexpression of delta SOS or RAC17N also did not affect the increase in glucose uptake induced by these stimuli. A serine/threonine kinase Akt, a constitutively active mutant of which was previously shown to stimulate glucose uptake, is activated by insulin, GH, and hyperosmolarity to approximately 4-fold, approximately 2.1-fold, and approximately 2.3-fold over basal level, respectively. These results suggest that insulin-induced but neither GH- or hyperosmolarity-induced glucose uptake is PI 3-kinase-dependent, and neither RAS nor RAC is required for glucose uptake induced by these stimuli in 3T3-L1 adipocytes.", "domain": "chemistry", "round": 3} +{"url": "https://omictools.com/malonylation-site-prediction-category", "date": "2019-04-26T16:17:22Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-18/segments/1555578841544.98/warc/CC-MAIN-20190426153423-20190426175423-00111.warc.gz", "language_score": 0.925627589225769, "token_count": 315, "dump": "CC-MAIN-2019-18", "global_id": "webtext-fineweb__CC-MAIN-2019-18__0__141253889", "lang": "en", "text": "Malonylation site detection software tools | Post-translational modification data analysis\nMalonylation, a newly identified protein post-translational modification (PTM), has been proved to be evolutionarily conserved and is present in both eukaryotic and prokaryotic cells. However, its potential roles associated with human diseases remain largely unknown.\nAims to predict lysine-malonylation sites. SPRINT-MAl is a prediction model available as a web application that generates a predicted probability for each amino acid. This application only processes one protein sequence at a time. This method performs equally well for both mouse and human proteins but not for bacterial species, suggesting interesting similarities and differences in underlying physicochemical mechanisms of malonylation in different species.\nPredicts malonyllysine sites from protein primary sequences. Mal-Lys is a predictor which incorporates residue sequence order information, position-specific amino acid propensity and physicochemical properties was proposed. It can be helpful for a better understanding of lysine malonylation and a useful tool to identify potential lysine malonylation sites in proteins for further experimental consideration.\nPredicts malonylation for three species, MaloPred was developed by integrating various informative features and via an enhanced feature strategy. MaloPred is a malonylation site online prediction tool. It can be a powerful tool for the computational identification and characterization of protein malonylation on a large scale. MaloPred can provide more instructive guidance for further experimental investigation of protein malonylation.", "domain": "chemistry", "round": 3} +{"url": "http://discovery.ucl.ac.uk/1334517/", "date": "2017-04-27T05:54:04Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-17/segments/1492917121869.65/warc/CC-MAIN-20170423031201-00186-ip-10-145-167-34.ec2.internal.warc.gz", "language_score": 0.7781243324279785, "token_count": 334, "dump": "CC-MAIN-2017-17", "global_id": "webtext-fineweb__CC-MAIN-2017-17__0__219999420", "lang": "en", "text": "Floc formation, size distribution, and its transformation detected by online laser particle counter.\nSEPARATION SCIENCE AND TECHNOLOGY.\n(pp. 1725 - 1736).\nTAYLOR & FRANCIS INC\nCoagulation and flocculation are widely applied in water and wastewater treatment. Removal of suspended particles is essential in water treatment and greatly depends upon the performance of the coagulant and the production of flocs with suitable properties. For monitoring floc size, formation, and size transformation, no particle size method now can be considered ideal. In this work an on-line laser particle counter was used to follow coagulation with aluminum sulfate. The experiments showed that the floc formation and floc size distribution could be well monitored. The results showed that it is feasible to use particle counting for dosage control and for monitoring changes in floc formation, transformation and size distribution.\n|Title:||Floc formation, size distribution, and its transformation detected by online laser particle counter|\n|Event:||IWA International Conference on Particle Separation|\n|Dates:||2007-07-08 - 2007-07-12|\n|Keywords:||coagulation, flocculation, particle counter, floc size, WATER-TREATMENT, HUMIC FLOCS, FLOCCULATION, COAGULANTS, BREAKAGE, STRENGTH, SHEAR, ALUM|\n|UCL classification:||UCL > School of BEAMS\nUCL > School of BEAMS > Faculty of Engineering Science\nArchive Staff Only", "domain": "chemistry", "round": 3} +{"url": "http://www.rsh-polymere.de/grinding-agglomerating-equipment-for-separation.htm", "date": "2017-09-26T21:52:02Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-39/segments/1505818696696.79/warc/CC-MAIN-20170926212817-20170926232817-00618.warc.gz", "language_score": 0.9124643802642822, "token_count": 448, "dump": "CC-MAIN-2017-39", "global_id": "webtext-fineweb__CC-MAIN-2017-39__0__44360130", "lang": "en", "text": "Grinding, agglomerating, equipment for separation\nRSH POLYMERE GmbH has a separate processing line for grinding various plastic fractions in each of its Hamburg-Harburg and Garstedt plants. Total monthly production capacity in both plants is about 500 tonnes.\nThe regrinds are usually refined in our own regranulating and compounding sections. A small number of regrinds is also sold.\nWe can shred a wide range of production waste on our state-of-the-art equipment. We can accept the raw materials in the following forms:\n- as lumps, pipes, sheets, moulded parts of any type etc.\nThe range of plastic types for grinding include:\n- LDPE, HDPE, PP, mixed polyolefin fractions, PS, ABS, PC/ABS, SAN, ASA, PC, PA and PET.\nIn our plant in Garstedt, we have a separate production line for agglomerating different plastic fractions. The preparation method here allows particularly lightweight, or thin-walled plastic waste to be densified and therefore in a pourable state for further processing. The agglomerates are used in our own regranulating and compounding sections and offered for sale.\nWe are looking for the following plastic types for agglomeration: PE, PP, ABS, PS, TPO and others, for example as cuttings, films and nonwovens.\nEquipment for separation\nIn our Garstedt plant, we also have a separate production line for separating slightly soiled or mixed regrinds and granulates. The float/sink method is applied which uses water to separate the mixed or soiled plastics from one another due to their different specific density.\nWe are constantly looking for mixed regrinds and granulates. Just to give a few examples: HDPE and PP regrind from pipes that might be mixed with PS or PVC, or a PP regrind which is mixed with ABS etc. Regrinds and granulates are also usable that are soiled with a little sand or other unwelcome materials (waste swept up).", "domain": "chemistry", "round": 3} +{"url": "http://www.springer.com/materials/mechanics/book/978-94-007-6918-2?otherVersion=978-94-007-6918-2", "date": "2015-02-01T00:34:42Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2015-06/segments/1422115857200.13/warc/CC-MAIN-20150124161057-00037-ip-10-180-212-252.ec2.internal.warc.gz", "language_score": 0.9053686857223511, "token_count": 477, "dump": "CC-MAIN-2015-06", "global_id": "webtext-fineweb__CC-MAIN-2015-06__0__111470626", "lang": "en", "text": "Springer eBooks may be purchased by end-customers only and are sold without copy protection (DRM free). Instead, all eBooks include personalized watermarks. This means you can read the Springer eBooks across numerous devices such as Laptops, eReaders, and tablets.\nYou can pay for Springer eBooks with Visa, Mastercard, American Express or Paypal.\nAfter the purchase you can directly download the eBook file or read it online in our Springer eBook Reader. Furthermore your eBook will be stored in your MySpringer account. So you can always re-download your eBooks.\nProvides modern analytical instruments and techniques available for determining the mechanical properties in the nanoscopic domain\nLists key parameters that influence the ultimate results obtained from analysis\nIncludes dedicated chapters on nanomechanical properties of the high performance materials help researchers in conducting similar experiments in their field of research\nAppeals to both young scholars as well as to advanced researchers\nThis book is intended for researchers who are interested in investigating the nanomechanical properties of materials using advanced instrumentation techniques. The chapters of the book are written in an easy-to-follow format, just like solved examples. The book comprehensively covers a broad range of materials such as polymers, ceramics, hybrids, biomaterials, metal oxides, nanoparticles, minerals, carbon nanotubes and welded joints. Each chapter describes the application of techniques on the selected material and also mentions the methodology adopted for the extraction of information from the raw data. This is a unique book in which both equipment manufacturers and equipment users have contributed chapters. Novices will learn the techniques directly from the inventors and senior researchers will gain in-depth information on the new technologies that are suitable for advanced analysis. On the one hand, fundamental concepts that are needed to understand the nanomechanical behavior of materials is included in the introductory part of the book. On the other hand, dedicated chapters describe the utilization of advanced numerical modeling in understanding the properties of complex materials. This book is useful for students and researchers from diverse backgrounds including chemistry, physics, materials science & engineering, biotechnology and biomedical engineering. It is well suited as a textbook for students and as a reference book for researchers.\nContent Level »Research\nKeywords »Failure Analysis - High Performance Materials - Nanomechanical Properties", "domain": "chemistry", "round": 3} +{"url": "https://www.bioscience.co.uk/product~69870", "date": "2020-07-07T22:24:21Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-29/segments/1593655895944.36/warc/CC-MAIN-20200707204918-20200707234918-00253.warc.gz", "language_score": 0.8415289521217346, "token_count": 463, "dump": "CC-MAIN-2020-29", "global_id": "webtext-fineweb__CC-MAIN-2020-29__0__152583177", "lang": "en", "text": "Antibody was affinity purified using an epitope specific to Sec23IP/MSTP053) immobilized on solid support. The epitope recognized by A300-594A maps to a region between residue 950 and the C-terminus (residue 1000) of human Sec23-Interacting Protein using the numbering given in entry NP_009121.1 (GeneID 11196). Immunoglobulin concentration was determined by extinction coefficient: absorbance at 280 nm of 1.4 equals 1.0 mg of IgG.\nMSTP053, P125, P125A, SEC23-interacting protein\nbetween 950 and C-term\n2 - 8°C\nDetection of human Sec23IP(MSTP053) by western blot and immunoprecipitation. Samples: Whole cell lysate from HeLa (5, 15 and 50 µg for WB; 1 mg for IP, 20% of IP loaded) and HEK293T (50 µg for WB) cells. Antibodies: Affinity purified rabbit anti-Sec23IP(MSTP053) antibody BL2566 (Cat. No. A300-594A) used for WB at 0.04 µg/ml (A) and 1 µg/ml (B) and for IP at 3 µg/mg lysate. Sec23IP(MSTP053) was also immunoprecipitated using rabbit anti-Sec23IP(MSTP053) antibodies BL2564 (Cat. No. A300-592A) and BL2565 (Cat. No. A300-593A). Detection: Chemiluminescence with exposure times of 30 seconds (A) and 3 minutes (B).\nDetection of human Sec23IP(MSTP053) by immunohistochemistry. Sample: FFPE section of human ovarian carcinoma. Antibody: Affinity purified rabbit anti-expndtw-6 Sec23IP(MSTP053) (Cat. No. A300-594A Lot1) used at a dilution of 1:200 (1µg/ml). Detection: DAB", "domain": "chemistry", "round": 3} +{"url": "http://www.abcam.com/calpain-7-antibody-ab28213.html", "date": "2013-12-04T20:40:00Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2013-48/segments/1386163037418/warc/CC-MAIN-20131204131717-00080-ip-10-33-133-15.ec2.internal.warc.gz", "language_score": 0.8284633755683899, "token_count": 601, "dump": "CC-MAIN-2013-48", "global_id": "webtext-fineweb__CC-MAIN-2013-48__0__79329255", "lang": "en", "text": "Anti-Calpain 7 antibody (ab28213)\n- Product nameAnti-Calpain 7 antibodySee all Calpain 7 primary antibodies ...\n- DescriptionRabbit polyclonal to Calpain 7\n- SpecificityThis antibody does not cross react with the other calpain family members (calpain 1, calpain 2, Calpain 3, ncl 3, etc.)\n- Tested applicationsWB more details\n- Species reactivityReacts with: Mouse, Rat, Human\nSynthetic peptide based on Domain III of the large subunit of human calpain 7. (Peptide available as ab41350.)\n- EpitopeThis antibody reacts to the carboxy end of Domain III of Calpain 7.\n- Storage instructionsStore at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze / thaw cycles.\n- Storage bufferPreservative: 0.05% Sodium Azide\nConstituents: 50% Glycerol\n- Concentration information loading...\n- PurityImmunogen affinity purified\n- Clonality Polyclonal\n- Research Areas\nOur Abpromise guarantee covers the use of ab28213 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\n- RelevanceCalpain proteinases are defined currently as papain-like neutral proteases that are calcium activated. Calpains 1 and 2 are composed of a large subunit, which is proteolytically active, and a small subunit (also called calpain 4), or enhancer protein, that is not proteolytically active. The other calpain proteins identified to date (Calpain 5, 6, 8, 9, 10, 11, 12, 13, 14, 15) are not known to require a small subunit. Domains in the large subunit include the amino terminal domain-I, the proteinase domain-II, domain-III, and the EF-hand domain-IV (domain-T in calpains 5 & 6, domain-N for calpain 7). Calpain 7 domain-N does not have the standard calpain EF hand domain for binding calcium, making it unclear whether it is calcium regulated. In place of the EF hand calcium-binding domain IV, Calpain 7 has a sequence most closely resembling domain-III, with unknown function. Calpain 7 is widely distributed, found in most tissues analyzed.\n- Cellular localizationNuclear\n- Calpain like protease antibody\n- Calpain7 antibody\n- CAPN 7 antibody\n- Homolog of Aspergillus Nidulans PALB antibody\n- PALBH antibody\nReferences for Anti-Calpain 7 antibody (ab28213)\nab28213 has not yet been referenced specifically in any publications.", "domain": "chemistry", "round": 3} +{"url": "https://www.reportsanddata.com/press-release/global-cement-admixture-market", "date": "2023-09-28T20:50:26Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233510454.60/warc/CC-MAIN-20230928194838-20230928224838-00612.warc.gz", "language_score": 0.9087017774581909, "token_count": 1523, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__142695959", "lang": "en", "text": "Global Cement Admixture Market Size to Reach USD 48.89 Billion in 2032\nThe major factor driving market revenue growth is the emerging construction industry in the developing region, which has enormous growth potential.\nMarket Size – USD 20.23 Billion in 2022, Market Growth – at a CAGR of 9.3%, Expected Market Size – USD 48.89 Billion in 2032, Market Trends – Increasing the use of admixtures to create lightweight concrete.\nNew York, 25 Aug, 2023 - The global cement admixture market size was USD 20.23 Billion in 2022 and is expected to register a revenue CAGR of 9.3% over the forecast period, according to the latest report by Reports and Data.\nConcrete admixtures play a crucial role in enhancing various aspects of concrete in the construction industry. They can improve manageability, overall quality, and even influence the speed of the hardening process, among other characteristics that can be tailored to meet specific construction objectives. This versatility has led to a substantial demand for these products in construction.\nFor example, set retarding concrete admixtures are employed to delay the chemical reaction that initiates when concrete starts to set. These specific additives are often utilized to mitigate the effects of high temperatures that could otherwise cause concrete to harden too quickly. Set retarding admixtures find applications in various construction scenarios, such as in the construction of concrete sidewalks, where they help prevent the formation of cold joints, extend the available time for finishing concrete pavements, and ultimately reduce the expenses associated with building new concrete batch plants. This, in turn, contributes to the overall revenue growth of the market.\nThe increasing utilization of admixtures for the production of lightweight concrete is a significant driver behind the market's revenue growth. Lightweight concrete has become increasingly essential in the construction sector. Most of the current research in concrete technology is centered on high-performance concrete, which aims to provide an affordable substance that meets rigorous performance criteria, including longevity. This trend fuels the demand for lightweight concrete with admixtures.\nTypically, lightweight concrete mixes incorporate lightweight aggregates. The strength of lightweight concrete can vary from 0.3 N/mm2 (44 psi) to 40 N/mm2 (5,800 psi), with a cement concentration of 13 lb/ft3 (200 kg/m3) or less. The strength of lightweight concrete is significantly influenced by its mass. The density of lightweight concrete ranges from 19 lb/ft3 (300 kg/m3) to 115 lb/ft3 (1,850 kg/m3). Structural lightweight concrete's self-weight is relatively lighter than that of ordinary concrete, yet it possesses sufficient strength for structural purposes.\nLightweight concrete offers several advantages, including reduced bulk, improved thermal and acoustic insulation, all while maintaining adequate strength. The reduced weight contributes to various benefits, including lower energy requirements during construction. For example, it reduces the dead load, enabling faster construction progress and reducing the costs associated with transportation and processing. When dealing with soft ground and tall structures, the weight of the foundation becomes a primary safety consideration in construction.\nThe market's revenue growth is being driven by an increase in the use of admixtures to shorten the early hardening time of cement concrete. Concrete is made with a high starting strength by using calcium chlorides as a cement hydration process booster to hasten setting time. 29% calcium chloride is an admixture for concrete that hastens the setting process. It is designed to reduce set time and facilitate placing and finishing concrete. When pouring concrete in cold weather, using 29% calcium chloride is especially beneficial. Since calcium chloride is the main accelerator used in concrete, the initial and final setting times are significantly shortened. Due to the quicker finishing and earlier use of slabs in low temperatures, it is primarily used in those conditions.\nTo understand how our Cement Admixture Market can bring difference to your business strategy:-Download Summary\nSome Key Highlights from the Report\n- In 2022, the superplasticizers segment dominated the revenue charts. Superplasticizers play a crucial role in crafting fluid concrete with a substantial slump, typically ranging from seven to nine inches. This specialized concrete is extensively utilized in heavily fortified structures and areas where traditional consolidation through vibration is challenging, contributing significantly to the revenue surge in this segment. Another notable application of superplasticizers is in producing high-strength concrete with water-to-cement ratios ranging from 0.3 to 0.4. This process has demonstrated its ability to enhance the workability of concrete across various cement types. Nevertheless, it's important to note that utilizing superplasticizers for substantial water reduction in concrete can lead to the challenge of slump loss. To counter this, superplasticizer-infused high-workability concrete can be engineered with excellent freeze-thaw resistance, albeit requiring an elevation in air capacity compared to standard concrete.\n- The market in North America accounted for largest revenue share in 2022. Rising activities by various major companies to develop new plants in this region is expected to drive revenue growth of the market in this region.\n- Some of the prominent players profiled in the global cement admixture market include Buildtech Products, Sika AG, RAZON Construction Chemicals, Flowcrete, MBCC Group, BASF SE, GCP, RPM International Inc, MAPEI S.p.A., and CICO Group.\n- Euclid Chemical, a leading manufacturer of goods, announced the product launch of three new concrete admixtures for brickwork and concrete on February 16, 2022: EUCOSHIELD, EUCON Eco-Strength, and EUCON AM-10L. EUCOSHIELD, an integral finishing additive, is a ready-to-use liquid admixture that binds the interior water in the pore structure to prevent fast moisture loss from the concrete surface. It works especially well when performing concrete operations in hot, breezy, light, or low relative humidity conditions. EUCON Eco-Strength, a strengthening additive, promotes the development of early and late-age concrete strengths. Through the potential reduction of total cementitious content, EUCON Eco-Strength improves strength development and enables the implementation of sustainable building practices.\nFor the purpose of this report, Reports and Data has segmented the global cement admixture market on the basis of Product Type Outlook, End-Use Outlook, and Regional Outlook:\nProduct Type Outlook (Revenue, USD Billion; 2022 - 2032)\n- Normal Plasticizers\n- Accelerating Admixtures\n- Retarding Admixtures\n- Air-Entraining Admixtures\n- Water-proofing Admixtures\nEnd-Use Outlook (Revenue, USD Billion; 2022 - 2032)\nRegional Outlook (Revenue, USD Billion; 2022-2032)\n- North America\n- Rest of Europe\n- South Korea\n- Rest of APAC\n- Latin America\n- Rest of LATAM\n- Middle East & Africa\n- Saudi Arabia\n- South Africa\n- Rest of MEA", "domain": "chemistry", "round": 3} +{"url": "https://parshvchem.com/products/nitro_benzene_granules", "date": "2024-04-13T06:49:55Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712296816586.79/warc/CC-MAIN-20240413051941-20240413081941-00228.warc.gz", "language_score": 0.8546639084815979, "token_count": 269, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__183939308", "lang": "en", "text": "Parshv Chem Industries have years of Industrial Experience and Offers quality Nitro Benzene Granules in the market.\nNitrobenzene is a plant energizer, Flowering stimulants and yield booster.\nNitrobenzene Granules are ideal for horticultural and agricultural applications.\nIt enhances the plant canopy and induces profuse flowering and thereby increases the yield,. for crops like cotton, Paddy, Wheat, Soyabeen,Chillies, Brinjal, Tomato and other vegetable crops, Pulses, oil seeds, fruits and flowering crops.\nwe provide these Nitrobenzene Granules in various packaging options as per the different requirement of our clients.\n- Nitrobenzene is a plant energiser and flower stimulant.\n- It helps the plant to increase CN ratio significantly.\n- It increases plant size and helps for flowering.\n- It enhances the plant canopy and induces flowering and increases the yield.\n- It can be used in all major agriculture crops through foliar application.\n- It is compatible with pesticide and fungicides and PGR Products.\n- Having wetting quality can work as sticking agent as well.\n- It used as a excellent plant growth promoter in agriculture.", "domain": "chemistry", "round": 3} +{"url": "http://www.origene.com/antibody/TA303517.aspx", "date": "2015-05-28T10:42:55Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2015-22/segments/1432207929272.95/warc/CC-MAIN-20150521113209-00280-ip-10-180-206-219.ec2.internal.warc.gz", "language_score": 0.8820139765739441, "token_count": 629, "dump": "CC-MAIN-2015-22", "global_id": "webtext-fineweb__CC-MAIN-2015-22__0__6418633", "lang": "en", "text": "Home Antibody All anti-FN1 antibodies\nAnti-FN1 Antibody F1\n|A recombinant protein was used as immunogen.|\n|Human (Does not react with: Mouse, Rat)\n||Lot dependent; please refer to CoA along with shipment\n|WB, IHC, IF\n||IHC-Fr: 1:250; WB: 1:50000; IHC-P: Use at an assay dependent dilution; IP: 1:50; ICC/IF: 1:100\n|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|\n|Does not react with Mouse, Rat\n* Availability is in business days\n* OriGene provides validated application data and protocol, with money back guarantee.\nWestern blot - Fibronectin antibody [F1]; Anti-Fibronectin antibody [F1] at 1/50000 dilution + human plasma.Predicted band size : 263 kDa.Additional bands at : 240 kDa. We are unsure as to the identity of these extra bands.\nImmunohistochemistry (Paraffin-embedded sections) - Fibronectin antibody [F1]; Immunohistochemical analysis of fibronectin in paraffin embedded human stomach tissue, using TA303517 at 1/250.\nImmunocytochemistry/ Immunofluorescence - Anti-Fibronectin antibody [F1]; ICC/IF image of TA303517 stained human mesenchymal stem cells. The cells were fixed in paraformaldehyde and then incubated in 0.1%BSA / 1% goat serum for 30 minutes, to block non-specific protein-protein interactions. The cells were then incubated with the antibody for 2 hours at 22°C. The secondary antibody (green) was Alexa Fluor 488 goat anti-rabbit IgG. DAPI was used to stain the cell nuclei (blue).\nImmunocytochemistry/ Immunofluorescence - Anti-Fibronectin antibody [F1]; ICC/IF image of TA303517 stained HepG2 cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody TA303517 at 1/100 dilution overnight at +4°C. The secondary antibody (green)was DyLight 488 goat anti- rabbit IgG (H+L) used at a 1/1000 dilution for 1h. Alexa Fluor 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43uM.", "domain": "chemistry", "round": 3} +{"url": "https://spleituras.tocalivros.com/ebook/how-to-boost-your-metabolism-karl-lendel-bibliomundi", "date": "2023-03-22T09:22:58Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-14/segments/1679296943809.22/warc/CC-MAIN-20230322082826-20230322112826-00266.warc.gz", "language_score": 0.951866626739502, "token_count": 255, "dump": "CC-MAIN-2023-14", "global_id": "webtext-fineweb__CC-MAIN-2023-14__0__248466698", "lang": "en", "text": "Some people think metabolism is a kind of organ, or a body part, that influences digestion. Actually, the metabolism isn’t a body part. Metabolism, is the process of transforming food (e.g. nutrients) into fuel (e.g. energy). The body uses this energy to conduct a vast array of essential functions. In fact, your ability to read this page is driven by your metabolism. If you had no metabolism you wouldn’t be able to move. In fact, long before you realized that you couldn’t move a finger or lift your foot, your internal processes would have stopped, because the basic building blocks of life – circulating blood, transforming oxygen into carbon dioxide, expelling potentially lethal wastes through the kidneys and so on – all of these depend on metabolism. Although we think of our metabolism as a single function, it’s really a catch-all term for countless functions that are taking place inside the body. Every second of every minute of every day of your life numerous chemical conversions are taking place through metabolism, or metabolic functioning. In a certain light, the metabolism has been referred to as a harmonizing process that manages to achieve two critical bodily functions that seem to be at odds with each other.", "domain": "chemistry", "round": 3} +{"url": "https://monsieur-de-coudicanne.com/dating-methods-other-than-carbon/", "date": "2019-12-11T11:38:35Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-51/segments/1575540530857.12/warc/CC-MAIN-20191211103140-20191211131140-00076.warc.gz", "language_score": 0.9362574815750122, "token_count": 566, "dump": "CC-MAIN-2019-51", "global_id": "webtext-fineweb__CC-MAIN-2019-51__0__182808055", "lang": "en", "text": "See other objections raised by a technique is carbon dating? Absolute dating, pike's team turned to decay of rocks and many applications of dating, radiocarbon dating methods of the past. For archaeologists and other methods of 1950 ad or. Since carbon-14 dating has lost argon will deal with the earth and. Instead, which won for decades, radiocarbon dating methods were. Left and https://monsieur-de-coudicanne.com/ fossils and the carbon 14, we will be. Luckily, documents, 730 for something besides the critical assumption for young less than the age. Dating methods, carbon-14 levels in all methods allow one of decay rate of turin. On the atmospheric c-14 is not considered by. Carbon-14 dating is used in the age of a couple https://kathleencooperfinepapers.com/dating-at-work-rules/ 14c dating is stonehenge. Discussion focuses on anything older than one sample. The data can sweep away top layers and. Instead, like any other materials is another often used to come from manetho's egyptian king-list, researchers use some of the other methods, other radioactive. For samples of the age, and therefore can be used in the method called numerical dating doesn't work well on c14 method works on. Make no bones about it was formed in this paper will focus on so, uranium-lead dating agrees with their remains of biological materials is another. Consequently dating method that another common radiometric methods, jordan rodgers dating objects younger earth or other words, the inaccuracies found using accelerator. It was suspected by carbon-14, radiocarbon dating method works, this method known as for telling the age materials as absolute dating can. Conditions for scientists use phylogeny, but whether by dr. At least to samples considerably older than 1/3 of radiocarbon dating, from a method is different than 60 years. If one sample is another often used to determine if an ancient artifacts which are cited, which. Relative-Dating definition of rock or other species of human sciences use of protons in. Among the best-known techniques are some of an old. Chart of carbon-dating of the remainder to find out the carbon in calendar. In the most Full Article available to date objects several. Plants take up c14 along with other radiometric. Now use today to find out a nobel. It takes another often the radioactive isotope carbon-14 in younger artifacts. This method can measure these atoms have been. It was suspected by kelvin, the other radiometric dating. Dating, if how the cosmic rays creating 14c ages of radioactive isotope of. Helpful terms chronometric dating, relative dating, other ways to be.", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/igg3-antibody-kt94-hrp-ab170490.html", "date": "2020-03-28T19:05:56Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-16/segments/1585370492125.18/warc/CC-MAIN-20200328164156-20200328194156-00354.warc.gz", "language_score": 0.6616635918617249, "token_count": 673, "dump": "CC-MAIN-2020-16", "global_id": "webtext-fineweb__CC-MAIN-2020-16__0__41443475", "lang": "en", "text": "Product nameAnti-IgG3 antibody [KT94] (HRP)\nSee all IgG3 primary antibodies\nDescriptionRat monoclonal [KT94] to IgG3 (HRP)\nTested applicationsSuitable for: WB, ELISAmore details\nSpecies reactivityReacts with: Mouse\nFull length protein corresponding to Mouse IgG3.\n- Mouse IgG3\nStorage instructionsShipped at 4°C. Store at +4°C.\nStorage bufferPreservative: 0.01% Thimerosal (merthiolate)\nConstituent: 99% PBS\nConcentration information loading...\nPurityProtein G purified\n- TMB ELISA Substrate (Highest Sensitivity) (ab171522)\n- TMB ELISA Substrate (High Sensitivity) (ab171523)\n- TMB ELISA Substrate (Fast Kinetic Rate) (ab171524)\n- TMB ELISA Substrate (Slow Kinetic Rate) (ab171525)\n- TMB ELISA Substrate (Slower Kinetic Rate) (ab171526)\n- TMB ELISA Substrate (Slowest Kinetic Rate) (ab171527)\n- 450 nm Stop Solution for TMB Substrate (ab171529)\n- 650 nm Stop Solution for TMB Substrate (ab171531)\n- Immunoassay Blocking Buffer (ab171534)\n- Immunoassay Blocking (BSA Free) (ab171535)\nOur Abpromise guarantee covers the use of ab170490 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\n|WB||1/1000. Predicted molecular weight: 44 kDa.|\nRelevanceIgG3, like IgG1, activates complement and has an affinity for fc receptors; thus IgG1 and IgG3 are the more effective of the IgG subclasses. An IgG3 deficiency is associated with Wiscott-Aldrich disease, systemic lupus erythematosus, juvenile diabetes mellitus, and peridontal infections. IgG anti-viral antibodies are restricted to IgG subclasses 1 and 3, with IgG3 antibodies being the first to appear in response to infection.\n- DKFZp686H11213 antibody\n- FLJ39988 antibody\n- FLJ40036 antibody\nAll lanes : Anti-IgG3 antibody [KT94] (HRP) (ab170490) at 1/1000 dilution\nLane 1 : Mouse IgG1\nLane 2 : Mouse IgG2a\nLane 3 : Mouse IgG2b\nLane 4 : Mouse IgG3\nLane 5 : Mouse IgM\nPerformed under reducing conditions.\nPredicted band size: 44 kDa\nDAB substrate used\nELISA showing cross-reactivity to various immunoglobulins using ab170490 at 1/1000 dilution.\nab170490 has not yet been referenced specifically in any publications.", "domain": "chemistry", "round": 3} +{"url": "http://www.astm.org/Standards/D4066.htm", "date": "2013-05-23T12:30:38Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2013-20/segments/1368703306113/warc/CC-MAIN-20130516112146-00016-ip-10-60-113-184.ec2.internal.warc.gz", "language_score": 0.8744727969169617, "token_count": 1020, "dump": "CC-MAIN-2013-20", "global_id": "webtext-fineweb__CC-MAIN-2013-20__0__132569180", "lang": "en", "text": "This classification system covers nylon materials suitable for injection molding and extrusion. Some of these compositions are also suitable for compression molding and application from solution.\nFormerly under the jurisdiction of Committee D20 on Plastics, this standard was withdrawn in November 2012 in accordance with section 10.6.3.1 of the Regulations Governing ASTM Technical Committees, which requires that standards shall be updated by the end of the eighth year since the last approval date. It is replaced by Classification System D6779.\n1.1 This classification system covers nylon materials suitable for injection molding and extrusion. Some of these compositions are also suitable for compression molding and application from solution.\n1.2 The properties included in this classification system are those required to identify the compositions covered. There may be other requirements necessary to identify particular characteristics important to specialized applications. These may be specified by using the suffixes as given in Section 5.\n1.3 This classification system and subsequent line call-out (specification) are intended to provide a means of calling out plastic materials used in the fabrication of end items or parts. It is not intended for the selection of materials. Material selection should be made by those having expertise in the plastic field after careful consideration of the design and the performance required of the part, the environment to which it will be exposed, the fabrication process to be employed, the costs involved, and the inherent properties of the material other than those covered by this classification system.\n1.4 The values stated in SI units are to be regarded as the standard.\n1.5 The following precautionary caveat pertains only to the test methods portion, Section 11, of this classification system. This standard does not purport to address all of the safety concerns, if any, associated with its use. It is the responsibility of the user of this standard to establish appropriate safety and health practices and determine the applicability of regulatory limitations prior to use.\nNote 1—This classification system is similar to ISO 1874-1/-2 1993, although the technical content is significantly different.\nNote 2—This classification system is being revised to include international 4-mm specimens and test procedures as the standard for compliance. The 3.2-mm specimens; test methods; and Tables PA, A, and B are included in Appendix X3 as a reference for those wishing to use them. It is recommended that the material manufacturer be consulted on all call-outs against this classification system.\n2. Referenced Documents (purchase separately) The documents listed below are referenced within the subject standard but are not provided as part of the standard.\nD149 Test Method for Dielectric Breakdown Voltage and Dielectric Strength of Solid Electrical Insulating Materials at Commercial Power Frequencies\nD150 Test Methods for AC Loss Characteristics and Permittivity (Dielectric Constant) of Solid Electrical Insulation\nD256 Test Methods for Determining the Izod Pendulum Impact Resistance of Plastics\nD257 Test Methods for DC Resistance or Conductance of Insulating Materials\nD618 Practice for Conditioning Plastics for Testing\nD638 Test Method for Tensile Properties of Plastics\nD648 Test Method for Deflection Temperature of Plastics Under Flexural Load in the Edgewise Position\nD789 Test Methods for Determination of Solution Viscosities of Polyamide (PA)\nD790 Test Methods for Flexural Properties of Unreinforced and Reinforced Plastics and Electrical Insulating Materials\nD792 Test Methods for Density and Specific Gravity (Relative Density) of Plastics by Displacement\nD883 Terminology Relating to Plastics\nD1600 Terminology for Abbreviated Terms Relating to Plastics\nD3418 Test Method for Transition Temperatures and Enthalpies of Fusion and Crystallization of Polymers by Differential Scanning Calorimetry\nD3641 Practice for Injection Molding Test Specimens of Thermoplastic Molding and Extrusion Materials\nD3892 Practice for Packaging/Packing of Plastics\nD4000 Classification System for Specifying Plastic Materials\nD5630 Test Method for Ash Content in Plastics\nD6260 Test Method for Gravimetric Determination of Carbon Black in Nylon Materials (PA)\nE29 Practice for Using Significant Digits in Test Data to Determine Conformance with Specifications\nMilitary and Federal Specifications and Standards\nVV-I-530 Insulating Oil, Electrical (for Transformers, Switches, and Circuit Breakers)\nclassification; classification system; line callout; plastic materials; Line call-out specifications--plastics; Molding/extrusion compounds/materials--specifications; Nylon plastics (PA); Plastics--specifications; Polyamide (PA)--specifications; Classification (standards)--plastics; Composition analysis--plastics;\nASTM International is a member of CrossRef.\nCiting ASTM Standards\n[Back to Top]", "domain": "chemistry", "round": 3} +{"url": "http://classicgalleriesjewelry.com/health-fitness/physical-properties-of-dental-materials.php", "date": "2019-03-26T00:48:25Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-13/segments/1552912204736.6/warc/CC-MAIN-20190325234449-20190326020449-00006.warc.gz", "language_score": 0.7833619117736816, "token_count": 394, "dump": "CC-MAIN-2019-13", "global_id": "webtext-fineweb__CC-MAIN-2019-13__0__67999238", "lang": "en", "text": "10 Oct Physical properties of dental materials by Dr Mujtaba Ashraf. 1/93Mujtaba Ashraf. Introduction Definition The various physical properties include: Hardness. • Color and color perception. Dental materials are the very basic of modern dentistry. 27 Apr 1) Elastic(reversible) deformation i.e proportional limit, resilience, modulus of elasticity. 2) Plastic (irreversible) deformation i.e percentage elongation. 3) Combination of elastic and plastic deformation i.e toughness or yield strength. STRESS: Force per unit area. Critical physical properties are established which protects the public. PROPERTIES OF DENTAL MATERIALS. I. Physical Properties. II. Thermal Properties. III.\n19 Oct - 26 min - Uploaded by Daniel Kishimoto Physics applied to Dental Materials. Physical Properties of Dental Materials. Daniel. Physical Properties of Dental Materials Presented by Karma Yangchen JR Physical properties of Dental Materials are based on: The laws of mechanics-Creep & flow, abrasion and abrasion resistance, viscosity. Thermodynamics e.g. Thermal conductivity, Thermal diffusivity and Coefficient of thermal expansion. PHYSICAL PROPERTIES OF DENTAL MATERIALS*. By WILMER SOUDER,t Washington, D. C.. (Read before the American Dental Association, Dallas, Texas, .\nTreating dentin hypersensitivity of noncarious lesions with chemical occlusion, physical occlusion, and nerve desensitization probably reduces pain, but there is . Define brittleness and discuss how this property applies to restorative dental materials. To begin a discussion of the physical properties of dental materials, it is. Physical Properties & Mechanical Properties of dental material Proportional Limit Elastic Limit The greatest stress that a material will sustain without a.", "domain": "chemistry", "round": 3} +{"url": "http://boccacciellobistrot.com/category/uncategorized/", "date": "2023-12-04T04:18:38Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100523.4/warc/CC-MAIN-20231204020432-20231204050432-00821.warc.gz", "language_score": 0.9474806785583496, "token_count": 366, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__68264794", "lang": "en", "text": "Arlon is an extraordinary sort of silicone elastic item that can be utilized for a wide range of sorts of utilizations. The things that anybody can do with it are incredible to see. Here are the absolute best advantages of this basic elastic item and how it functions with various applications.\nIt highlights quartz\nThe issue with numerous sorts of elastic items is that they incorporate oil backing materials. These materials are utilized to help hold the elastic’s capacity to deal with various sorts of conditions. It is exceptionally invaluable to certain things yet it is not as solid as quartz. Quartz, probably the hardest mineral on the planet, is the foundation of an Arlon silicone elastic item. This will assist with making it impervious to various distinctive intense conditions.\nIt can deal with numerous flares\nA major some portion of Arlon is that it is a fire safe material. It makes them quench properties on it. This makes it something that will make it suitable to use in regions that manage elevated levels of warmth and start factors. It can even remain predictable in smoke.\nA major factor for this originates from how it has a high scope of temperatures that it can work it. It can deal with temperatures of 400 degrees Fahrenheit or more. This is something that is liquid silicone rubber molding to deal with high warmth conditions than some different sorts of rubbers that are utilized in mechanical cycles.\nIt tends to be made into numerous things\nThis type of elastic can be incorporated with a wide range of sorts of utilizations. Arlon can be made into such things as gels, fluids and sheets. These are altogether applications that will be utilized by various kinds of machines and can be particularly helpful for anybody to exploit. Investigating the utilization of this silicone elastic for various assembling needs is emphatically prescribed with regards to getting things arranged.", "domain": "chemistry", "round": 3} +{"url": "http://www.labome.org/species/cellular/fungi/ustilaginomycotina/malasseziaceae/malassezia-globosa-cbs-7966-425265.html", "date": "2020-01-19T17:25:11Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-05/segments/1579250594662.6/warc/CC-MAIN-20200119151736-20200119175736-00004.warc.gz", "language_score": 0.852863609790802, "token_count": 317, "dump": "CC-MAIN-2020-05", "global_id": "webtext-fineweb__CC-MAIN-2020-05__0__53508315", "lang": "en", "text": "Malassezia globosa CBS 7966\nLee H, Park H, Lim Y, Lee I, Kim B, Seong C, et al\n. Functional expression and characterization of recombinant NADPH-P450 reductase from Malassezia globosa. J Microbiol Biotechnol. 2012;22:141-6 pubmed\n..These results demonstrate that purified NPR is an orthologous reductase protein that supports cytochrome P450 enzymes in M. globosa. ..\nHiragun T, Ishii K, Hiragun M, Suzuki H, Kan T, Mihara S, et al\n. Fungal protein MGL_1304 in sweat is an allergen for atopic dermatitis patients. J Allergy Clin Immunol. 2013;132:608-615.e4 pubmed publisher\n..MGL_1304 is a major allergen in human sweat and could cause type I allergy in patients with AD. ..\nJuntachai W, Oura T, Kajiwara S. Purification and characterization of a secretory lipolytic enzyme, MgLIP2, from Malassezia globosa. Microbiology. 2011;157:3492-9 pubmed publisher\n..This enzyme had optimal activity at 30 °C and pH 5.0. Furthermore, the activity significantly increased in the presence of Triton X-100 and was partially inhibited by PMSF but was unaffected by univalent and divalent metal ions...", "domain": "chemistry", "round": 3} +{"url": "https://oldfloridapioneer.com/qa/question-is-there-an-alternative-to-coking-coal.html", "date": "2021-08-05T06:11:25Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-31/segments/1627046155322.12/warc/CC-MAIN-20210805032134-20210805062134-00102.warc.gz", "language_score": 0.9508618116378784, "token_count": 1186, "dump": "CC-MAIN-2021-31", "global_id": "webtext-fineweb__CC-MAIN-2021-31__0__91173864", "lang": "en", "text": "- Can steel be made without using coal?\n- Which is the best form of coal?\n- Which burns hotter coal or coke?\n- Why is Coke used instead of coal?\n- What are 4 types of coal?\n- What is the difference between thermal coal and coking coal?\n- What is m40 in Coke?\n- What is CSN in coking coal?\n- Why do you need coal to make steel?\n- What is Coke vs coal?\n- What is the difference between coking and non coking coal?\n- What is the best house coal?\n- How is coke obtained from coal?\n- Which is a better fuel coal or coke?\n- What is CSR and CRI of coke?\nCan steel be made without using coal?\nNow, nearly all new steel globally is produced using iron oxide and coking coal.\nCoking coal is usually bituminous-rank coal with special qualities that are needed in the blast furnace.\nWhile an increasing amount of steel is being recycled, there is currently no technology to make steel at scale without using coal..\nWhich is the best form of coal?\nWhat are the types of coal?Anthracite: The highest rank of coal. … Bituminous: Bituminous coal is a middle rank coal between subbituminous and anthracite. … Subbituminous: Subbituminous coal is black in color and dull (not shiny), and has a higher heating value than lignite.More items…•\nWhich burns hotter coal or coke?\nWhat is the difference between coal and coke fuel? Coal is a shiny, black fossil fuel that contains impurities, emits smoke when burned, and produces less heat than coke. Coke is a dull, black byproduct of coal that burns hotter and cleaner.\nWhy is Coke used instead of coal?\nSince smoke-producing constituents are driven off during the coking of coal, coke forms a desirable fuel for stoves and furnaces in which conditions are not suitable for the complete burning of bituminous coal itself. Coke may be combusted producing little or no smoke, while bituminous coal would produce much smoke.\nWhat are 4 types of coal?\nCoal is classified into four main types, or ranks: anthracite, bituminous, subbituminous, and lignite. The ranking depends on the types and amounts of carbon the coal contains and on the amount of heat energy the coal can produce.\nWhat is the difference between thermal coal and coking coal?\nThermal coal, also called steaming coal, has a lower energy content and higher moisture and is used to generate electricity. Metallurgical or coking coal has a higher energy content and lower moisture and is used to make iron, steel and other metals.\nWhat is m40 in Coke?\nThe coke is characterized in terms of quality indices M40 and M10. Index M40 is the expression as a percentage of the fraction greater than 40 mm that is left in the drum. M10 index is the percentage fraction less than 10 mm from the test resulting.\nWhat is CSN in coking coal?\n7. Crucible Swelling Number (CSN): The range of CSN in coking coal is 3 of a minimum to a maximum 6. Prime coking coal has high CSN value while soft coking coal has low CSN value. 8. Maximum Dilatation: The value of maximum dilatation is 55% minimum.\nWhy do you need coal to make steel?\nAround 1% of the carbon from the coke remains in the raw iron to provide the source of that carbon. So coal (as coke) is a reducing agent, a source of energy to drive the process and a source of carbon to incorporate in the steel.\nWhat is Coke vs coal?\nBy distilling bituminous coal in retorts to obtain gas for illumination, or by burning it in kilns or pits, the residue left behind is called coke, which is simply coal charcoal, and is nearly pure carbon.\nWhat is the difference between coking and non coking coal?\nA non-caking coal is that coal which on heating in absence of air doesn’t from a coherent mass of residue. … A coking coal is that coal which on heating in absence of air leaves a solid residue. A non-coking coal also leaves a solid coherent residue which may not possess the physical & chemical properties of the coke.\nWhat is the best house coal?\nColumbian coalBituminous house coal is mined all over the world but Columbian coal is considered to be the best house coal available for domestic use.\nHow is coke obtained from coal?\nMetallurgical coke is produced by destructive distillation of coal in coke ovens. Prepared coal is “coked”, or heated in an oxygen-free atmosphere until all volatile components in the coal evaporate. The material remaining is called coke.\nWhich is a better fuel coal or coke?\nCoke is a better fuel than coal because; -Coke produces more heat on burning than coal. … When equal masses of coke and coal are burnt, coke produces more heat. -When coke is burnt smoke is not obtained.\nWhat is CSR and CRI of coke?\nTest procedure The coke is preheated and cooled under nitrogen and the weight loss during reaction is measured. The percentage weight loss is known as the reactivity (CRI). … The percent of carbon material removed from the drum that is +10 mm is known as the coke strength after reaction (CSR).", "domain": "chemistry", "round": 3} +{"url": "https://www.rdm.ox.ac.uk/publications/22210", "date": "2023-11-30T11:02:56Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100184.3/warc/CC-MAIN-20231130094531-20231130124531-00853.warc.gz", "language_score": 0.9265154600143433, "token_count": 346, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__188050184", "lang": "en", "text": "Autoantibodies to islet amyloid polypeptide in diabetes.\nClark A., Yon SM., de Koning EJ., Holman RR.\nIslet amyloid polypeptide (IAPP) is the constituent peptide of amyloid in pancreatic islets of Type 2 diabetic patients and in insulinomas. Amyloid formation in Type 2 diabetes is associated with islet cell destruction which may promote formation of autoantibodies to IAPP. An ELISA method has been developed to detect IAPP autoantibodies and used to assay serum from 80 non-diabetic subjects, 49 Type 1 and 228 Type 2 diabetic patients, and 10 patients with insulinomas. Microtitre plates coated with IAPP 1-37 were used to detect antibody binding followed by an alkaline phosphatase conjugated anti-human IgG. ELISA binding decreased with sample dilution and with pre-incubation of the samples with IAPP. The optical density of the substrate reaction was compared with results from a standard serum from a non-diabetic subject (OD ratio). Elevated OD ratios were detected in some subjects from each patient group but the Type 2 diabetic group had significantly higher titres than the non-diabetic subjects (p less than 0.001). The OD ratio was elevated (greater than mean + 2SD non-diabetic group) in 15% of Type 2 and 18% of Type 1 diabetic patients and in 20% with insulinomas. IAPP antibody levels did not correlate with age or gender of subjects, or duration of diabetes. IAPP autoantibodies could be an additional marker for B-cell damage in diabetes.", "domain": "chemistry", "round": 3} +{"url": "https://www.benscrub.com/products/blp-eyeshadow-pen---copper-brown-5g", "date": "2020-01-25T17:41:37Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-05/segments/1579251678287.60/warc/CC-MAIN-20200125161753-20200125190753-00252.warc.gz", "language_score": 0.7536807060241699, "token_count": 284, "dump": "CC-MAIN-2020-05", "global_id": "webtext-fineweb__CC-MAIN-2020-05__0__30124797", "lang": "en", "text": "BLP Eyeshadow Pen - Copper Brown (5g)\nIf you need extra oomph around the eyes, this iridescent copper shadow should be on top of your list. It smoothly blends with other lighter or darker shades, while providing just the right dimension for various eye shapes.\nIsododecane, Synthetic Wax, Polyethylene Terephthalate, Ethylene/Propylene Copolymer, Polymethylsilsesquioxane, Silica, Polybutene, Hydrogenated Polydicyclopentadiene, Sucrose Tetrastearate Triacetate, Coco-Caprylate/Caprate, Oryza Sativa Cera, Synthetic Beeswax, Hydrogenated Castor Oil, Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate, Polyurethane-11\nMica, CI 77499, CI 77491, CI 77891, CI 19140, CI 77000\n- Always make sure your pencil is sharp as possible, use the PENCIL SHARPENER so you can get a precise finish.\n- Run the eyeshadow pencil across your lash line and blend upwards and outwards across the socket. Sweep, blend or smudge with your finger! The formula sets after 30 seconds, so make sure you work quickly!", "domain": "chemistry", "round": 3} +{"url": "https://research.aalto.fi/en/publications/imaging-inelastic-fracture-processes-in-biomimetic-nanocomposites", "date": "2023-09-30T17:01:30Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233510697.51/warc/CC-MAIN-20230930145921-20230930175921-00084.warc.gz", "language_score": 0.8639227151870728, "token_count": 328, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__223033637", "lang": "en", "text": "Mollusk nacre is a prototypical biological inorganic-organic composite that combines high toughness, stiffness, and strength by its brick-and-mortar microstructure, which has inspired several synthetic mimics. Its remarkable fracture toughness relies on inelastic deformations at the process zone at the crack tip that dissolve stress concentrations and stop cracks. The micrometer-scale structure allows resolving the size and shape of the process zone to understand the fracture processes. However, for better scalability, nacre-mimetic nanocomposites with aligned inorganic or graphene nanosheets are extensively pursued, to avoid the packing problems of mesoscale sheets like in nacre or slow in situ biomineralization. This calls for novel methods to explore the process zone of biomimetic nanocomposites. Here the fracture of nacre and nacre-inspired clay/polymer nanocomposite is explored using laser speckle imaging that reveals the process zone even in absence of changes in optical scattering. To demonstrate the diagnostic value, compared to nacre, the nacre-inspired nanocomposite develops a process zone more abruptly with macroscopic crack deflection shown by a flattened process zone. In situ scanning electron microscopy suggests similar toughening mechanisms in nanocomposite and nacre. These new insights guide the design of nacre-inspired nanocomposites toward better mechanical properties to reach the level of synergy of their biological model.\n- Mechanical properties\n- Process zone", "domain": "chemistry", "round": 3} +{"url": "https://radonc.uchicago.edu/research/bishop-and-connell-lab", "date": "2022-06-30T22:03:40Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-27/segments/1656103915196.47/warc/CC-MAIN-20220630213820-20220701003820-00484.warc.gz", "language_score": 0.8571836352348328, "token_count": 545, "dump": "CC-MAIN-2022-27", "global_id": "webtext-fineweb__CC-MAIN-2022-27__0__146279056", "lang": "en", "text": "The lab is under the direction of Dr. Doug Bishop, who joined the University in 1993. He has served as principal investigator for several research projects, including many receiving funding from the US Army and the National Science Foundation.\nThe Bishop Lab also collaborates with Dr. Phil Connell, a graduate of the department's radiation oncology residency program. Clinically, Dr. Connell focuses on sarcomas and mediastinal tumors, but he also remains active in cancer biology research.\nDr. Bishop supervises several other members of the lab, including research associates, technicians, postdoctoral scholars and students.\nThe Bishop lab studies the mechanism of homologous repair, emphasizing the recombination proteins Dmc1 and Rad51 that are related to the bacterial repair protein RecA. The investigation considers how Dmc1's function is specialized for meiosis, how the functions of Rad51 and Dmc1 differ, and how these proteins interact.\n- Budke B, Logan HL, Kalin JH, Zelivianskaia AS, Cameron McGuire W, Miller LL, Stark JM, Kozikowski AP, Bishop DK, Connell PP. RI-1: a chemical inhibitor of RAD51 that disrupts homologous recombination in human cells.Nucleic Acids Res. 2012 May 9.\n- Shah PP, Zheng X, Epshtein A, Carey JN, Bishop DK, Klein HL. Swi2/Snf2-related translocases prevent accumulation of toxic Rad51 complexes during mitotic growth. Mol Cell. 2010 Sep 24;39(6):862-72.\n- Ferrari SR, Grubb J, Bishop DK. The Mei5-Sae3 protein complex mediates Dmc1 activity in Saccharomyces cerevisiae. J Biol Chem. 2009 May 1;284(18):11766-70. Epub 2009 Mar 7.\n- Jayathilaka K, Sheridan SD, Bold TD, Bochenska K, Logan HL, Weichselbaum RR, Bishop DK, Connell PP. A chemical compound that stimulates the human homologous recombination protein RAD51. Proc Natl Acad Sci U S A. 2008 Oct 14;105(41):15848-53.\n- Sheridan SD, Yu X, Roth R, Heuser JE, Sehorn MG, Sung P, Egelman EH, Bishop DK. A comparative analysis of Dmc1 and Rad51 nucleoprotein filaments. Nucleic Acids Res. 2008 Jul;36(12):4057-66. Epub 2008 Jun 4.", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/dnajc6-antibody-ab262876.html", "date": "2020-06-06T15:07:48Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-24/segments/1590348513321.91/warc/CC-MAIN-20200606124655-20200606154655-00072.warc.gz", "language_score": 0.7132499814033508, "token_count": 676, "dump": "CC-MAIN-2020-24", "global_id": "webtext-fineweb__CC-MAIN-2020-24__0__64266035", "lang": "en", "text": "Product nameAnti-DNAJC6 antibody\nSee all DNAJC6 primary antibodies\nDescriptionRabbit polyclonal to DNAJC6\nTested applicationsSuitable for: IHC-P, ICC/IF, WBmore details\nSpecies reactivityReacts with: Human\n- WB: Rt-4 and U-251 MG cell lysates; ICC/IF: U-2OS cells; IHC-P: Human cerebral cortex tissue.\nStorage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.\nStorage bufferpH: 7.20\nPreservative: 0.02% Sodium azide\nConstituents: 40% Glycerol, PBS\nConcentration information loading...\nPurityImmunogen affinity purified\nOur Abpromise guarantee covers the use of ab262876 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\n|IHC-P||1/2500 - 1/5000. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.|\n|ICC/IF||Use a concentration of 1 - 4 µg/ml.\nFixation/Permeabilization: PFA/Triton X-100\n|WB||Use a concentration of 0.4 µg/ml.|\nRelevanceDNAJC6 belongs to the evolutionarily conserved DNAJ/HSP40 family of proteins, which regulate molecular chaperone activity by stimulating ATPase activity. DNAJ proteins may have up to 3 distinct domains: a conserved 70-amino acid J domain, usually at the N terminus, a glycine/phenylalanine (G/F)-rich region, and a cysteine-rich domain containing 4 motifs resembling a zinc finger domain.\n- auxilin antibody\n- DJC6 antibody\n- DnaJ (Hsp40) homolog, subfamily B, member 6 antibody\nLane 1 : Marker\nLanes 2-3 : Anti-DNAJC6 antibody (ab262876) at 0.4 µg/ml\nLane 2 : RT-4 cell lysate\nLane 3 : U-251 MG sp cell lysate\nPFA-fixed, Triton X-100 permeabilized human U-2OS cells stained for DNAJC6 (green) using ab262876 at 4 µg/ml in ICC/IF.\nParaffin-embedded Human cerebral cortex tissue stained for DNAJC6 using ab262876 at 1/2500 dilution in immunohistochemical analysis.\nParaffin-embedded Human pancreas tissue stained for DNAJC6 using ab262876 at 1/2500 dilution in immunohistochemical analysis.\nTo our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.\nab262876 has not yet been referenced specifically in any publications.", "domain": "chemistry", "round": 3} +{"url": "https://openagriculturejournal.com/VOLUME/16/ELOCATOR/e187433152207270/ABSTRACT/", "date": "2023-09-29T14:21:02Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233510516.56/warc/CC-MAIN-20230929122500-20230929152500-00126.warc.gz", "language_score": 0.8558776378631592, "token_count": 702, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__138096626", "lang": "en", "text": "Effect of Different Tannery Sludge Composts on the Production of Ryegrass: A Pot Experiment\nAdelaide Perdigão1, 2, 3, Francisco Marques1, 2, José L. S. Pereira1, 2, *\nIdentifiers and Pagination:Year: 2022\nE-location ID: e187433152207270\nPublisher ID: e187433152207270\nArticle History:Received Date: 10/3/2022\nRevision Received Date: 11/4/2022\nAcceptance Date: 19/5/2022\nElectronic publication date: 27/09/2022\nCollection year: 2022\nopen-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.\nTannery industry produces high amounts of nutrient rich sludges that can be used as organic fertilizers.\nThe aim of this study was to evaluate the fertilizing potential of composted tannery sludge.\nA pot experiment was carried out with ryegrass (Lolium perenne L.) to test two different composts: 2.0 kg dry matter (DM) tannery fatty sludge + 1.5 kg DM sheep manure + 1.5 kg DM wheat straw (Compost 1) and 2.0 kg DM tannery sludge + 1.5 kg DM sheep manure + 1.5 kg DM wheat straw (Compost 2). Five treatments, with three replicates each, were assigned: Control (C); Compost 1 at 6 t (C1-6) and 12 t (C1-12) DM ha-1; Compost 2 at 6 t (C2-6) and 12 t (C2-12) DM ha-1. Each treatment was applied in a pot and mixed with 5 kg of sieved soil (<2 mm).\nResults showed that production of DM ranged between 1.2 t DM ha-1 for C1-6 and 2.4 t DM ha-1 for C2-12. The highest B, Na and N levels in ryegrass was observed in C2-12, with 175 mg kg-1 DM, 9 g kg-1 DM and 30 g kg-1 DM, respectively. At the end of the experiment no differences were observed between treatments for C, N, P2O5, and K2O levels. Differences were observed at Zn level ranged between 101 mg kg-1 DM for C1-6 and 71 mg kg-1 DM for C2-12.\nThe C2-12 treatment was the best because induces higher DM production and nutrients in ryegrass and without dangerous concentration of heavy metals in soil. Composted waste from the tannery industry is a good source of nutrients for agriculture.", "domain": "chemistry", "round": 3} +{"url": "https://saemobilus.sae.org/content/2003-01-1970", "date": "2022-10-07T03:19:56Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-40/segments/1664030337906.7/warc/CC-MAIN-20221007014029-20221007044029-00141.warc.gz", "language_score": 0.7512902021408081, "token_count": 910, "dump": "CC-MAIN-2022-40", "global_id": "webtext-fineweb__CC-MAIN-2022-40__0__214870061", "lang": "en", "text": "This content is not included in your SAE MOBILUS subscription, or you are not logged in.\nChemical Characterization of Surface Films Generated from Continuously Variable Transmission Fluids Using XAFS\nISSN: 0148-7191, e-ISSN: 2688-3627\nPublished May 19, 2003 by SAE International in United States\nAnnotation ability available\nAn important function of belt-drive continuously variable transmission fluids (B-CVTFs) is to transmit engine torque between the belt and pulley. We studied the frictional properties of B-CVTFs using the reciprocating type of friction tester. To understand the mechanism of this torque transmission, the effects of the composition of the metal surface films on the metal frictional properties must be determined. This determination is difficult to do with electron probe microanalysis (EPMA), auger electron spectroscopy (AES), and x-ray photoelectron spectroscopy (XPS), the techniques that are usually used to investigate surface films.\nThis paper describes the chemical characterization of metal surface films generated by B-CVTFs using x-ray absorption fine structure (XAFS).\nCitationWada, H., Iwanami, Y., and Nomura, M., \"Chemical Characterization of Surface Films Generated from Continuously Variable Transmission Fluids Using XAFS,\" SAE Technical Paper 2003-01-1970, 2003, https://doi.org/10.4271/2003-01-1970.\n- Watts R. F. “Future Challenges in the Lubrication of Belt and Chain Drive CVT's” Proceedings of 2001 TVT symposium Toyota 67 2001\n- Kaneko H. Kugimiya T. Kuribayashi T. Arai H. Honda A. Akiyama S. “Development of CVTF for Steel Pushing V-belt CVT” Proceedings of 2001 TVT symposium Toyota 87 2001\n- Peiffer R. Mueller H. D. Ahrweiler P. Mitsui H. “Next Generation Automatic Transmission Fluids Challenges and Chances to Develop a Fluid for all Transmission Systems” Proceedings of 2001 TVT symposium Toyota 93 2001\n- Sato T. Yamamoto Y. “Mechanism of Additives in Belt-type CVT Contact Area” Proceedings of ITC Nagasaki 1379 2000\n- Narita K. Deshimaru J. Kato M. “The Influence of Lubricating Oil on the Performance of a Metal V-Belt TYPE CVT” Proceedings of ITC Nagasaki 1367 2000\n- Tersigni S. H. Strait D. L. Mccombas T. A. Bell I. R. “Designinig Fluids for CVTs” Proceedings of 2001 TVT symposium Toyota 71 2001\n- Mogi Y. Murakami Y. “Required Characteristics of Fluids for Future Belt CVTs” Proceedings of 2001 TVT symposium Toyota 10 2001\n- Kakegawa K. Mitsui H. “Fluids for High Torque Transmitting Belt-Drive CVTs” Proceedings of 1998 TVT symposium Yokohama 132 1998\n- Mabuchi Y. Kano M. Ishikawa T. Sano A. Wakizono T. “The Effect of ZDDP Additive in CVT Fluid on Increasing Friction Coefficient between Belt Elements and Pullys of Belt-Drive Continuously Variable Transmissions” Trib. Trans. 43 229 2000\n- Ward, W. H. Jr. Whitticar D. J. Cerda de Groote C. L. Ikeda M. “CVT Fluid Friction Evaluation Using a Reciprocating Test Method” JSAE Spring Convention Proceedings, No.15-00 1 2000\n- Kasrai M. Cutler J. N. Gore K. Canning G. Bancroft G. M. Tan K. H. “The Chemistry of Antiwear Films Generated by the Combination of ZDDP and MoDTC Examined by X-ray Absorption Spectroscopy” Trib. Trans. 41 69 1998", "domain": "chemistry", "round": 3} +{"url": "https://acs.figshare.com/articles/dataset/l_Proline_Catalyzed_Three_Component_Domino_3_2_1_Annulation_for_the_Regio_and_Diastereoselective_Synthesis_of_Highly_Substituted_Thienothiopyrans_Containing_Three_or_Four_Stereocenters/2799373/1", "date": "2022-08-16T11:21:31Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882572286.44/warc/CC-MAIN-20220816090541-20220816120541-00168.warc.gz", "language_score": 0.7977873682975769, "token_count": 313, "dump": "CC-MAIN-2022-33", "global_id": "webtext-fineweb__CC-MAIN-2022-33__0__1694362", "lang": "en", "text": "l-Proline-Catalyzed Three-Component Domino [3+2+1] Annulation for the Regio- and Diastereoselective Synthesis of Highly Substituted Thienothiopyrans Containing Three or Four Stereocenters\ndatasetposted on 15.01.2010, 00:00 authored by Sethuraman Indumathi, Subbu Perumal, J. Carlos Menéndez\nl-Proline-catalyzed three-component reactions of ethyl 2-[(2-oxo-2-arylethyl)sulfonyl]acetate or ethyl 2-[(2-ethoxy-2-oxoethyl)sulfonyl]acetate, aromatic aldehydes, and 5-aryltetrahydro-3-thiophenone furnished a variety of highly substituted thieno[3,2-c]thiopyran derivatives. This facile transformation presumably occurs via a one-pot domino sequence of enamine formation/aldol condensation/Michael addition/6-exo-trig cyclization/elimination and involves the creation in a single operation of three C−C bonds and the generation of three new stereocenters with complete diastereoselectivity in all cases and a fourth one in ca. 7:3 diastereomeric ratio when starting from a 5-substituted tetrahydro-3-thiophenone derivative.", "domain": "chemistry", "round": 3} +{"url": "https://soloseries.org/auto-racing/why-do-race-cars-use-water-instead-of-coolant.html", "date": "2022-06-29T10:05:49Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-27/segments/1656103626162.35/warc/CC-MAIN-20220629084939-20220629114939-00657.warc.gz", "language_score": 0.948222279548645, "token_count": 1122, "dump": "CC-MAIN-2022-27", "global_id": "webtext-fineweb__CC-MAIN-2022-27__0__160069006", "lang": "en", "text": "Water is not as viscous so it flows much easier than coolant without robbing too much engine power in the process (think: water pump). Water is also very good at removing heat however it is prone to boiling and freezing at the extremes, which coolant does much better in.\nCan a car run on just water instead of coolant?\nEven though many people choose to simply put water into their radiators instead of coolant, it is not really a good idea. … While water does help to keep your engine cool, it does not work nearly as well as coolant does. First of all, water boils faster and at a lower temperature than coolant.\nWhat happens if I use water instead of coolant?\nIf you were to just use water rather than the coolant mixture, high temperatures inside the motor would easily boil that water and cause it to evaporate, meaning you’d quickly have no coolant at all and the engine would easily overheat.\nWhat do race cars use for coolant?\nIf you’ve ever wondered why race cars don’t use antifreeze, it’s because of the glycol that gives antifreeze it’s anti-freeze properties is also toxic, and dangerous should the liquid spill in the event of an accident or crash.\nWhy do we use water as coolant?\nWater is used as a coolant in automobiles radiators because it has high specific heat capacity. So, it absorbs a large amount of heat for a degree rise in temperature.\nCan I put water in the coolant?\nYour car’s cooling system needs coolant to keep it from overheating. Although water can be added to the radiator for this purpose, it’s preferable to add a mixture of coolant and water because plain water can boil before the proper coolant will boil, causing your engine to overheat [source: pontiac].\nHow long can I drive with low coolant level?\nIf the coolant is low but above the minimum mark, then you are still fine to run the car for a few days, but if the coolant is below the minimum mark, please do not even try to drive your car like that so you don’t knock your engine. You need to top up the coolant.\nWhat coolant does my car need?\nFor most vehicles, a glycol based antifreeze coolant is the best type of coolant to be used in any vehicle radiator. … Most vehicle manufacturers recommend a 50/50 mix of glycol antifreeze and water when vehicles require adequate cooling but do not need much protection from the cold of a harsh winter.\nWhat happens if I add water to 50/50 coolant?\nMost manufacturers recommend a 50/50 mix of antifreeze concentrate to water. Mixtures with too much water may not provide adequate boil over or freeze protection. Mixtures with too much antifreeze concentrate may actually cause over heating.\nCan you use any coolant for any car?\nWell, you use the coolant that is specified in your owner’s manual. If you just need to top it up, the recommendation is still the same, however it is unlikely to cause any serious problems if you add a litre of a different type of coolant, as long as you follow the manufacturer’s maintenance schedule.\nHow long do race car engines last?\nMost production car engines are designed to last over 100,000 miles. NASCAR race car engines are designed to last one race (500 miles, in the case of the Daytona 500). While the same version of an engine is typically used for an entire season, it is rebuilt after each race.\nHow many horsepower is a Nascar 2020?\nIn these two events, – which used the 550-horsepower package in its three events in 2020 — NASCAR Cup Series teams will be running the 750-horsepower, low-downforce package that was run at tracks one mile in length and under, as well as at road courses.\nDo dragsters use coolant?\nMany of the A/ND dragsters don’t use any coolant. The blocks are filled more for rigidity than anything else. The reason they can run without coolant is because they use alcohol and their fuel. The alcohol being sprayed thru injectors does it’s own cooling, plus they use up quite a bit of it making a pass.\nHow long can I use water as coolant?\nIn general, using water as coolant is OK for a short time or as a “get you home” alternative, but it does not have the anti-freeze and corrosion inhibiting properties of a proper coolant mix, so should not be left in the engine for any length of time, especially if you live in a cold climate.\nDoes water or antifreeze cool better?\nWhy Use Both? You may be wondering why both water and antifreeze are needed. While water is the best fluid for cooling, it can cause corrosion. Antifreeze has a lower freezing point and a higher boiling point than water so it helps protect your engine in extreme weather conditions.\nIs coolant the same as antifreeze?\nEngine coolant, also known as antifreeze, is mixed with water to keep the radiator from freezing in extreme cold and overheating in extreme heat.", "domain": "chemistry", "round": 3} +{"url": "https://scholar.archive.org/work/at4lc776cjdcvmsts4lbhbfjsy", "date": "2023-12-08T04:06:43Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100710.22/warc/CC-MAIN-20231208013411-20231208043411-00882.warc.gz", "language_score": 0.8833954334259033, "token_count": 711, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__115676507", "lang": "en", "text": "Cloning of upstream region and cellulose synthase operon genes involved in bacterial cellulose biosynthesis by Gluconacetobacter hansenii ATCC23769\nCellulose is a homopolysaccharide composed of extracellular D-glucose monomers connected by glycosidic linkages in b-1,4 conformation which can be synthesized by a variety of living organisms, possessing numerous applications in food, pharmaceutical, medical area, etc. . In 1990, cellulose synthase operon encoding four proteins required for bacterial cellulose (BC) biosynthesis by Gluconacetobacter hansenii was isolated. It was demonstrated that these genes bcsA, bcsB, bcsC and bcsD\n... together, required for maximum production of celulose . Later, researches identified other relevant regions for bacterial cellulose biosynthesis that occur upstream (cmcax and ccpAx genes) and downstream of the operon (bglx gene) . In this study, we aimed to clone the most important genes related to the BC synthesis. With the purpose of cloning those genes, the genomic DNA of the mentioned microorganism was extracted and proceeded with the amplification of cmcax, ccpAx and cellulose synthase operon genes. Later, the genes were ligated to a cloning vector, transformed in Escherichia coli and the identity of the clones was confirmed by sequencing and comparing with the GenBank using Blastn tool. The cloning achievement of the operon and upstream genes from G. hansenii and their overexpression will enable studies on BC synthesis improvement. Methods Extraction of bacterial genomic DNA was carried out using cell lysis under heating in the presence of sodium dodecyl sulfate (SDS) and proteinase K, followed by purification with a phenol:chloroform:isoamylic alcohol solution (PCI) and subsequent dialysis in TE buffer pH 8.0. The cloning of the genes related to the production of bacterial cellulose was carried out with amplification reactions (PCR) using specifically designed primers in the presence of Pfx Plantinum (Invitrogen) or Phusion (New England Biolabs) polymerases. The cloned genes were ligated to pTZ57R/T vector, transformed into ultracompetent Escherichia coli (DH10B) and sequencing was carried out using Big Dye ® Terminator v3.1 Cycle Sequencing Kit and the Genetic Analyzer 3130 (Applied Biosystems). Identity was confirmed with Blastn tool (Basic Local Alignment Search Tool). Results PCR reactions using G. hansenii genomic material and specific primers yield the fragments with the corresponding size of the upstream region (2.1 kb) and of cellulose synthase operon (9.0 kb). Finally, the sequencing of the cloned fragments allowed the confirmation of the identity of the genes cmcax and ccpAx and the genes of the BC operon from G. hansenii. Conclusions The obtained clones showed high identity with the genes located in the upstream region of the cellulose synthase operon and with the genes in the BC operon. The next step will allow the overexpression of these genes in G. hansenii ATCC23769 in order to check the cellulose production by the genetically modified microorganism in comparison with the wild microorganism.", "domain": "chemistry", "round": 3} +{"url": "https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13680738/", "date": "2020-10-21T19:47:22Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-45/segments/1603107877420.17/warc/CC-MAIN-20201021180646-20201021210646-00637.warc.gz", "language_score": 0.9104042649269104, "token_count": 456, "dump": "CC-MAIN-2020-45", "global_id": "webtext-fineweb__CC-MAIN-2020-45__0__89035074", "lang": "en", "text": "|Budget Amount *help\n¥1,500,000 (Direct Cost: ¥1,500,000)\nFiscal Year 2003: ¥700,000 (Direct Cost: ¥700,000)\nFiscal Year 2002: ¥800,000 (Direct Cost: ¥800,000)\n1)Liposomes are micro-compartments made of lipid bilayer membranes with characteristics quite similar to those of biological membranes. To form artificial cell-like structures, we generated liposomes that contained subunit proteins of cytoskeletons : actin, and its associating proteins. Spherical liposomes were transformed into disk-or dumbbell-shapes by the polymerization of encapsulated actin. Bipolar-or cell-like-shaped liposomes were developed by the assembly of encapsulated actin and its crosslinking proteins, fascin, -actinin, or filamin, by mechanical forces generated by the organization of internal actin-networks. Dynamic processes of morphological transformations of liposomes were visualized by high intensity dark-field light microscopy. The differences in morphology among transformed liposomes indicate that actin-crosslinking proteins determine liposome shape by organizing their specific actin networks. Morphological analysis reveals that the crosslinking manner, i.e. distance and angular flexibility between adjacent crosslinked actin filaments, is essential for the morphogenesis.\n2)Topological changes, such as fusion and division of membrane vesicles, play an essential role in cellular activities. To investigate the mechanism of these processes, we visualized the liposomes undergoing topological transformation induced by interactions between liposomal membranes and fusogenic peptides derived from influenza hemagglutinin, melittin, or surfactants with direct, real-time observation using high-intensity dark-field microscopy. As the results, a variety of novel topological transformations were found, including the opening-up of liposomes, the direct expulsion of inner vesicles, intermittent quakes, and inside-out topological inversion. These novel findings reveal that the lipid bilayer itself possesses the ability to undergo topological transformation.", "domain": "chemistry", "round": 3} +{"url": "https://how2removestains.com/how-to-remove-detergent-stains-from-clothes/", "date": "2023-09-21T18:32:50Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233506029.42/warc/CC-MAIN-20230921174008-20230921204008-00228.warc.gz", "language_score": 0.9157970547676086, "token_count": 1251, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__245282451", "lang": "en", "text": "The primary goal of detergents is to make our clothes clean, not to stain and leave unsightly spots on your clothes. Unfortunately, sometimes your clothes can appear worse after you wash them because of detergents. To help preserve your clothes, make sure you quickly remove detergent stains before you wear them.\nDetergent stains can seem challenging to remove, but you can remove them from your clothes by soaking the clothes in a vinegar solution before rinsing with water. Dish soap or a vinegar-baking soda paste are also effective alternatives when you want to get rid of detergent stains..\nRead on to find out how you can remove these stubborn stains with these methods.\nTable of Contents\nRemoving detergent stains from clothes using vinegar\nVinegar is an excellent agent in cleaning and deodorizing. It also plays an essential role in removing stains. It can dissolve detergent residue, which is why it works well on detergent stains.\nTo completely remove the stains, follow these procedures. It’s easy, and you can rock your favorite outfit again minus the stains.\n- Using a bar of soap, rub the stained area.\n- Rewash it with cold water.\n- In a container, pour white vinegar. The amount you’ll use will depend on the severity of the stains on your clothes.\n- Place your clothes inside the container and let it soak the white vinegar solution. Let it sit for 15 minutes, and never leave it for more than 30 minutes as it will spread the stains.\n- Remove it if you notice that the spots disappear.\n- Rinse and wash your clothes with water.\nThe primary reason for detergent stains is if your washing machine has a detergent dispenser that’s not working properly. The dispenser might be blocking the detergent from dissolving. You can clean it by using a half cup of vinegar and hot water.\nLiquid dish soap is also effective\nUsing liquid dishwashing detergent to remove detergent stains is another practical approach and is a relatively simple process. It has alkaline properties that can dissolve and neutralize dirt and acids. You don’t need to put force in rubbing, and stains will go away as easy as 1-2-3.\nFollow the procedure below for optimal results.\n- Soak the stained area with warm water.\n- Put a small portion of dishwashing liquid detergent on the stained area.\n- Rub the stained area until the stains are no longer visible.\n- If you’re dealing with hard detergent stains, try to apply some liquid dishwashing detergent again. Double the portion of the liquid dish soap this time.\n- When the stain finally disappears, rinse your clothes with water.\n- Allow it to air dry.\nAn at-home remedy for detergent stains on your clothes\nUnfortunately, your detergent can leave tiny white spots and ruin your outfit. To bring back your inner fashionista, follow this simple home remedy.\n- Rub the stained area with a bar of soap. You can use a soft-bristle brush if you do not want to scrub continuously.\n- If there are still stains on the fabric, mix one-half cup of baking soda and white vinegar. Apply the paste in the stained area. Let it sit for ten minutes.\n- Wash your clothes with soap to remove the baking soda and vinegar residue.\n- Use cold water to wash your clothes.\n- Allow it to air dry.\nCommonly asked questions about detergent stains\nWhere do detergent stains come from?\nDetergent stains can come from the following reasons:\n- Your detergent didn’t dissolve properly. Stains usually happen if you use cold water to wash your clothes. Some detergents need time and heat to fully dissolve.\n- The water that you use in your laundry is hard. Hard water occurs when the water isn’t pure and contains minerals. It can be the reason why the detergent is not dissolving properly, which leads to detergent stains.\n- You’ve used too much detergent. Remember, too much of anything isn’t usually good. Using too much detergent will lead to stains, so follow the instructions indicated on your detergent.\nAre detergent stains on clothes permanent?\nDetergent stains are not permanent, but they can be difficult to remove. That’s why it’s best to get rid of the stains as soon as you see them. You can get rid of them by simply running them through a water-only cycle, or with vinegar and baking soda.\nBe observant of your automatic washer. Make sure that your dispenser is properly working as you wash your clothes. Clean your washing machine regularly to avoid getting detergent stains on your favorite clothes.\nWhy do black clothes have white spots after washing?\nIt’s because of the detergent residue. To prevent detergent stains, make sure your detergent dissolves in the water completely when washing your clothes. If the water is too cold, it might prevent the detergent from dissolving. If you constantly have this issue, check your washing machine or switch detergent brands.\nHow do you keep clothes from getting detergent stains?\nIf you don’t want to deal with removing these stains on your clothes, you can prevent your clothes from getting detergent stains by adding white vinegar to your wash load instead of fabric softener. This will soften the clothes and break down the detergent.\nYou can also try mixing water softener and a minimal amount of detergent in a container with water. Place your clothes inside the mixture, and it’s less likely to leave detergent stains.\nPrevention is always better than allowing detergent stains to ruin your fashion style. But if detergent does stain your favorite clothes, don’t worry as you can remove it with any of the methods mentioned above. Never settle in wearing clothes with detergent stains and rock your favorite outfits without worry.", "domain": "chemistry", "round": 3} +{"url": "http://leavenotracecommunity.blogspot.com/2012/03/whats-in-your-campfire.html", "date": "2017-05-24T09:52:57Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-22/segments/1495463607811.15/warc/CC-MAIN-20170524093528-20170524113528-00499.warc.gz", "language_score": 0.9695274829864502, "token_count": 411, "dump": "CC-MAIN-2017-22", "global_id": "webtext-fineweb__CC-MAIN-2017-22__0__4631162", "lang": "en", "text": "While most people familiar with Leave No Trace generally do not burn trash, those who are uninformed occasionally (or perhaps more often) burn trash in their campfire. While this seemingly innocent act may not cause seemingly significant immediate impacts, there are impacts nonetheless. As with most recreation-related impacts, damage done to the environment is cumulative over time, and in the case of campfires it leads to fire rings full of partially burned trash and food waste that are often very attractive to wildlife. This then leads to other problems. For example, wildlife can become attracted and conditioned to human food and trash and seek out these items, often to their own detriment. Although these kinds of campfire related impact occur over time, there are much more acute campfire impacts from burning trash.\nIn 2004 the USDA Missoula Technology and Development Center, a USDA Forest Service research facility, studied the toxins released from various kinds of trash when burned in a campfire. The researchers burned everything from plastic bags to batteries to baby diapers. Over 27 different items were burned, and both the gas emissions and ash content were analyzed. The results were scary at best. Numerous chemicals, most of which are known carcinogens, were released from the burning trash. Lead, xylene and benzene were just a few of the many toxins released from burning trash.\nInterestingly enough, the study showed that even campfires that just burn wood released a significant amount of air pollutants. The addition of garbage greatly increased the pollutants and toxins released. Ash left over from a fire that contained only wood primarily consisted of nontoxic elements. However, when garbage was burned, toxic compounds in the ash were greatly increased. As a result, the researchers recommend that anyone handling campfire ash wear protective gloves. Furthermore, they recommended that all trash, regardless of what it is, be packed out and properly disposed of in a trash receptacle.\nTo view the full study, visit: http://air.ky.gov/SiteCollectionDocuments/WhatsBurninginYourCampfire_Article.pdf", "domain": "chemistry", "round": 3} +{"url": "https://www.spe.org/en/ogf/ogf-article-detail/?art=99", "date": "2017-11-25T09:29:41Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-47/segments/1510934809746.91/warc/CC-MAIN-20171125090503-20171125110503-00320.warc.gz", "language_score": 0.9445062279701233, "token_count": 572, "dump": "CC-MAIN-2017-47", "global_id": "webtext-fineweb__CC-MAIN-2017-47__0__106649989", "lang": "en", "text": "Feasibility and Evaluation of Surfactants and Gas Lift in Combination as a Severe-Slugging-Suppression Method\nAn experimental study of severe-slugging suppression by use of a combination of surfactants and gas lift was conducted with a facility comprising a 3-in.-inner-diameter, 65-ft-long, –3°-inclined flowline, followed by a 45-ft-long vertical-riser system. Air and water were used as fluids. The surfactant used was a foaming agent capable of forming stable foams in all brines for a wide range of pH values. Pressure behavior in the flowline/riser system was monitored, and input-gas-, injection-gas-, liquid-, and surfactant-flow rates were measured continuously. In addition, visual observations were made to identify severe slugging. Effects of the proposed method were quantified with a modified elimination performance index (MEPI) that considered not only pressure fluctuations, but also backpressure effects.\nThirty tests were conducted. The data were analyzed for the severe-slugging suppression of the combination of surfactant and gas lift, the effect of gas lift on surfactant injection, and the effect of the surfactant on the reduction of the gas lift gas. The combination technique with the highest gas lift rate completely eliminated the severe slugging for all tests conducted. Surfactants were able to suppress severe slugging for most of the cases. The performance of the “only-surfactant injection case” increases as the gas/liquid ratio increases. For all of the tests, backpressure reduction was observed. The MEPI is used as the main parameter to assess the performance of the severe-slugging-suppression methods. Gas lift not only contributes to density reduction through volumetric increase of gas in the riser, but it also reduces the mixture density by promoting more foam generation. There were reductions in the gas lift rate from the original maximum gas lift injection rate for all the tests conducted with surfactant injection.\nGATE Energy Joins Ranks of Contract Awardees for Noble’s Leviathan Project\nGATE Energy is the most recent contract awardee for Noble Energy’s Leviathan project offshore Israel. It will provide the commissioning of the production platform for the megaproject.\nShell Stands Down Emergency Response at Enchilada Platform\nShell reported it has not observed any signs of oil on the water associated with a fire on the Enchilada platform, located in the US Gulf of Mexico.\nUnderstanding Risk in Flow Assurance Management\nA BP flow assurance manager explains a methodology for determining and mitigating flow assurance risks.\n07 November 2017\n01 November 2017\n14 November 2017\n30 October 2017", "domain": "chemistry", "round": 3} +{"url": "https://q-pnl-am.org/research_article/", "date": "2023-01-27T11:28:37Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-06/segments/1674764494976.72/warc/CC-MAIN-20230127101040-20230127131040-00555.warc.gz", "language_score": 0.6653139591217041, "token_count": 3918, "dump": "CC-MAIN-2023-06", "global_id": "webtext-fineweb__CC-MAIN-2023-06__0__300491121", "lang": "en", "text": "- J. Piotrowska, Y. Jodoi, N.H. Trang, A. Wawrzynska, H. Takahashi, A. Sirko, A. Maruyama-Nakashita*\nThe C-terminal region of SLIM1 transcription factor is required for sulfur deficiency response.\nPlants 11: 2595 (2022)\n- T. Ito, T. Kitaiwa, K. Nishizono, M. Umahashi, S. Miyaji, S. Agake, K. Kuwahara, T. Yokoyama, S. Fushinobu, A. Maruyama-Nakashita, R. Sugiyama, M. Sato, J. Inaba, M.Y. Hirai, N. Ohkama-Ohtsu*\nGlutathione degradation activity of γ-Glutamyl Peptidase 1 manifests its dual roles in primary and secondary sulfur metabolism in Arabidopsis.\nPlant J. 111: 1626–1642 (2022)\n- M. Kusajima, M. Fujita, K. Soudthedlath, H. Nakamura, K. Yoneyama, T. Nomura, K. Akiyama, A. Maruyama-Nakashita, T. Asami, H. Nakashita*\nStrigolactones modulate salicylic acid-mediated disease resistance in Arabidopsis thaliana.\nInt. J. Mol. Sci. 23: 5246 (2022)\n- H. Li, A. Suyama, N. Mitani-Ueno, R. Hell, A. Maruyama-Nakashita*\nLow-level NaCl stimulates plant growth by improving carbon and sulfur assimilation in Arabidopsis thaliana.\nPlants 10: 2138 (2021)\n- A. Maruyama-Nakashita*, Y. Ishibashi, K. Yamamoto, L. Zhang, T. Morikawa-Ichinose, S.-J. Kim, N. Hayashi\nOxygen plasma modulates glucosinolate levels without affecting lipid contents and composition in Brassica napus seeds.\nBiosci. Biotech. Biochem. 85: 2434-2441 (2021)\n- M. Zhang, Y. Tashiro*, Y. Asakura, N. Ishida, K. Watanabe, S. Yue, A. Maruyama-Nakashita, K. Sakai\nLab-scale autothermal thermophilic aerobic digestion can maintain and remove nitrogen by controlling shear stress and oxygen supply system\nJ. Biosci. Bioeng. 132: 293-301 (2021)\n- A. Allahham, S. Kanno, L. Zhang, A. Maruyama-Nakashita*\nSulfur deficiency increases phosphate accumulation, uptake, and transport in Arabidopsis thaliana.\nInt. J. Mol. Sci. 21: 2971 (2020)\n- M. Kusajima, M. Fujita, T. Mori, K. Tsukamoto, T. Ushiwatari, H. Hayashi, A. Maruyama-Nakashita, H. Yamakawa, H. Nakashita*\nCharacterization of plant immunity-activating mechanism by a pyrazole derivative.\nBiosci. Biotech. Biochem. 84： 1427-1435 (2020)\n- T. Morikawa-Ichinose, D. Miura, L. Zhang, S.-J. Kim, A. Maruyama-Nakashita*\nInvolvement of BGLU30 in glucosinolate catabolism in the Arabidopsis leaf under dark conditions.\nPlant Cell Physiol. 61：1095-1106 (2020)\n- C. Yamaguchi, S. Khamsalath, Y. Takimoto, A. Suyama, Y. Mori, N. Ohkama-Ohtsu, A. Maruyama-Nakashita*\nSLIM1 transcription factor promotes sulfate uptake and distribution to shoot, along with phytochelatine accumulation, under cadmium stress in Arabidopsis thaliana.\nPlants 9: 163 (2020)\n- L. Zhang, R. Kawaguchi, T. Morikawa-Ichinose, A. Allahham, S.-J. Kim, A. Maruyama-Nakashita*\nSulfur deficiency-induced glucosinolate catabolism attributed to two ß-glucosidases, BGLU28 and BGLU30, is required for plant growth maintenance under sulfur deficiency.\nPlant Cell Physiol. 61：803-813 (2020)\n- T. Nakajima, Y. Kawano, I. Ohtsu, A. Maruyama-Nakashita, A. Allahham, M. Sato, Y. Sawada, M.Y. Hirai, T. Yokoyama, N. Ohkama-Ohtsu*\nEffects of thiosulfate as a sulfur source on plant growth, metabolites accumulation and gene expression in Arabidopsis and rice.\nPlant Cell Physiol. 60: 1683-1701 (2019)\n- Y. Kimura, T. Ushiwatari, A. Suyama, R. Tominaga-Wada, T. Wada, A. Maruyama-Nakashita*\nContribution of root hair development to sulfate uptake in Arabidopsis.\nPlants 8: 106 (2019)\n- T. Morikawa-Ichinose, S.-J. Kim, A. Allahham, R. Kawaguchi, A. Maruyama-Nakashita*\nGlucosinolate distribution in the aerial parts of sel1-10, a disruption mutant of the sulfate transporter SULTR1;2, in mature Arabidopsis thaliana plants.\nPlants 8: 95 (2019)\n- Y.-J. Park, J.-H. Chun, H. Woo, A. Maruyama-Nakashita, S.-J. Kim*\nEffects of different sulfur ion concentration in nutrient solution and light source on glucosinolate contents in kale sprouts.\nKorean J. Agric. Sci. 44: 261-271 (2017)\n- C. Yamaguchi, N. Ohkama-Ohtsu, T. Shinano, A. Maruyama-Nakashita*\nPlants prioritize phytochelatin synthesis during cadmium exposure even under reduced sulfate uptake caused by the disruption of SULTR1;2.\nPlant Signal. Behav. 12: e1325053 (2017)\n- A. Maruyama-Nakashita*, A. Suyama, H. Takahashi\n5'-non-transcribed flanking region and 5'-untranslated region play distinctive roles in sulfur deficiency induced expression of SULFATE TRANSPORTER 1;2 in Arabidopsis roots.\nPlant Biotech. 34: 51-5 (2017)\n- C. Yamaguchi, Y. Takimoto, N. Ohkama-Ohtsu, A. Hokura, T. Shinano, T. Nakamura, A. Suyama, A. Maruyama-Nakashita*\nEffects of Cadmium Treatment on the Uptake and Translocation of Sulfate in Arabidopsis thaliana.\nPlant Cell Physiol. 57: 2353-2366 (2016)\n- F. Aarabi, M. Kusajima, T. Tohge, T. Konishi, T. Gigolashvili, M. Takamune, Y. Sasazaki, M. Watanabe, H. Nakashita, A.R. Fernie, K. Saito, H. Takahashi, H.-M. Hubberten, R. Hoefgen, A. Maruyama-Nakashita*\nSulfur-deficiency-induced repressor proteins optimize glucosinolate biosynthesis in plants.\nSci. Advances 2: e1601087 (2016)\n- A. Maruyama-Nakashita*\nCombinatorial use of sulfur-responsive regions of sulfate transporters provides a highly sensitive plant-based system for detecting selenate and chromate in the environment.\nSoil Sci. Plant Nutr. 62: 386-391 (2016)\n- N. Yoshimoto, T. Kataoka, A. Maruyama-Nakashita, H. Takahashi*\nProtocol for measurement of sulfate uptake in Arabidopsis seedlings.\nBio-protocol 6: e1700 (2015)\n- A. Maruyama-Nakashita*, A. Watanabe-Takahashi, E. Inoue, T. Yamaya, K. Saito, H. Takahashi\nSulfur-responsive elements in the 3’-non-transcribed intergenic region are essential for the induction of Sulfate Transporter 2;1 gene expression in Arabidopsis roots under sulfur deficiency.\nPlant Cell 27: 1279-1296 (2015)\n- A. Maruyama-Nakashita*, MY. Hirai, S. Funada, S. Fueki\nExogenous application of 5-aminolevulinic acid increases transcript levels of sulfur transport and assimilatory genes, sulfate uptake, and cysteine and glutathione contents in Arabidopsis thaliana.\nSoil Sci. Plant Nutr. 56: 281-288 (2010)\n- C. Kawashima, N. Yoshimoto, A. Maruyama-Nakashita, Y. Tsuchiya, K. Saito, H. Takahashi, T. Dalamy*\nSulphur starvation induces the expression of microRNA-395 and one of its target genes but in different cell types.\nPlant J. 57: 313-321 (2009)\n- M. Yasuda, A. Ishikawa, Y. Jikumaru, M. Seki, T. Umezawa, T. Asami, A. Maruyama-Nakashita, T. Kudo, K. Shinozaki, S. Yoshida, H. Nakashita*\nAntagonistic interaction between systemic acquired resistance and the abscisic acid-mediated abiotic stress response in Arabidopsis.\nPlant Cell. 20: 1678-1692 (2008)\n- A. Maruyama-Nakashita*\nTranscriptional regulation of genes involved in sulfur assimilation in plants: Understanding from the analysis of high-affinity sulfate transporters.\nPlant Biotech. 25: 323-328 (2008)\n- H. Goda, E. Sasaki, K. Akiyama, A. Maruyama-Nakashita, K. Nakabayashi, W. Li, M. Ogawa, Y. Yamauchi, J. Preston, K. Aoki, T. Kiba, S. Takatsuto, S. Fujioka, T. Asami, T. Nakano, H. Kato, T. Mizuno, H. Sakakibara, S. Yamaguchi, E. Nambara, Y. Kamiya, H. Takahashi, M. Yokota Hirai, T. Sakurai, K. Shinozaki, K. Saito, S. Yoshida, Y. Shimada*\nThe AtGenExpress hormone and chemical treatment data set: experimental design, data evaluation, model data analysis and data access.\nPlant J. 55: 526-542 (2008)\n- A. Maruyama-Nakashita, E. Inoue, K. Saito, H. Takahashi*\nPotential use of sulfur-responsive promoter of sulfate transporter gene for detection and quantification of selenate and chromate in the environment.\nPlant Biotech. 24: 261-263 (2007)\n- A. Maruyama-Nakashita, Y. Nakamura, T. Tohge, K. Saito, H. Takahashi*\nArabidopsis SLIM1 is a central transcriptional regulator of plant sulfur response and metabolism.\nPlant Cell 18: 3235-3251 (2006)\n- A. Maruyama-Nakashita, Y. Nakamura, A. Watanabe-Takahashi, E. Inoue, T. Yamaya, H. Takahashi*\nIdentification of a novel cis-acting element conferring sulfur deficiency response in Arabidopsis roots.\nPlant J. 42: 305-314 (2005)\n- A. Maruyama-Nakashita, Y. Nakamura, T. Yamaya, H. Takahashi*\nRegulation of high-affinity sulfate transporters in plants: towards systematic analysis of sulfur signaling and regulation.\nJ. Exp. Bot. 55: 1843-1849 (2004)\n- A. Maruyama-Nakashita, Y. Nakamura, T. Yamaya, H. Takahashi*\nA novel regulatory pathway of sulfate uptake in Arabidopsis roots: implication of CRE1/WOL/AHK4-mediated cytokinin-dependent regulation.\nPlant J. 38: 779-789 (2004)\n- A. Maruyama-Nakashita, Y. Nakamura, A. Watanabe-Takahashi, T. Yamaya, H. Takahashi*\nInduction of SULTR1;1 sulfate transporter in Arabidopsis roots involves protein phosphorylation / dephosphorylation circuit for transcriptional regulation.\nPlant Cell Physiol. 45: 340-345 (2004)\n- A. Maruyama-Nakashita, E. Inoue, A. Watanabe-Takahashi, T. Yamaya, H. Takahashi*\nTranscriptome profiling of sulfur-responsive genes in Arabidopsis reveals global effects of sulfur nutrition on multiple metabolic pathways.\nPlant Physiol. 132: 597-605 (2003)\n- A. Maruyama, K. Ishizawa, K. Saito*\nß-Cyanoalanine synthase and cysteine synthase from potato: molecular cloning, biochemical characterization, and spatial and hormonal regulation.\nPlant Mol. Biol. 46: 749-760 (2001)\n- Y. Hatzfeld, A. Maruyama, A. Schmidt, M. Noji, K. Ishizawa, K. Saito*\nß-Cyanoalanine synthase is a mitochondrial cysteine synthase-like protein in spinach and Arabidopsis thaliana.\nPlant Physiol. 123: 1163-1172 (2000)\n- A. Maruyama, K. Ishizawa*, T. Takagi\nPurification and characterization of ß-cyanoalanine synthase and cysteine synthases from potato tubers. ß-Cyanoalanine synthase and mitochondrial cysteine synthase are the same enzyme?\nPlant Cell Physiol. 41: 200-208 (2000)\n- A. Maruyama, K. Ishizawa, T. Takagi, Y. Esashi*\nCytosolic ß-cyanoalanine synthase activity attributed to cysteine synthases in cocklebur seeds. Purification and characterization of cytosolic cysteine synthases.\nPlant Cell Physiol. 39: 671-680 (1998)\n- A. Maruyama, M. Yoshiyama, Y. Adachi, H. Nanba, R. Hasegawa, Y. Esashi*\nPossible participation of ß-cyanoalanine synthase in increasing the amino acid pool of cocklebur seeds in response to ethylene during the pre-germination period.\nAust. J. Plant. Physiol. (現Functional Plant Biology) 24: 751-757 (1997)\n- A. Maruyama, M. Yoshiyama, Y. Adachi, A. Tani, R. Hasegawa, Y. Esashi*\nPromotion of cocklebur seed germination by allyl, sulfur and cyanogenic compounds.\nPlant Cell Physiol. 37: 1054-1058 (1996)\n- Y. Esashi*, A. Maruyama, S. Sasaki, A. Tani, M. Yoshiyama\nInvolvement of cyanogens in the promotion of germination of cocklebur seeds in response to various nitrogenous compounds, inhibitors of respiratory and ethylene.\nPlant Cell Physiol. 37: 545-549 (1996)\n- M. Yoshiyama, A. Maruyama, T. Atsumi, Y. Esashi*\nMechanism of action of C2H4 in promoting the germination of cocklebur seeds. 3. A further enhancement of priming effect with nitrogenous compounds and C2H4 responsiveness of seeds.\nAust. J. Plant. Physiol. (現Functional Plant Biology) 23: 519-525 (1996)\n- R. Hasegawa, A. Maruyama, M. Nakaya, S. Tsuda, Y. Esashi*\nThe presence of two types of ß-cyanoalanine synthase in germinating seeds and their responses to ethylene.\nPhysiol. Plant. 93: 713-718 (1995b)\n- R. Hasegawa, A. Maruyama, H. Sasaki, T. Tada, Y. Esashi*\nPossible involvement of ethylene-activated ß-cyanoalanine synthase in the regulation of cocklebur seed germination.\nJ. Exp. Bot. 46: 551-556 (1995a)", "domain": "chemistry", "round": 3} +{"url": "https://www.metallurgical-research.org/articles/metal/ref/2020/01/metal190135/metal190135.html", "date": "2020-03-31T09:51:01Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-16/segments/1585370500426.22/warc/CC-MAIN-20200331084941-20200331114941-00049.warc.gz", "language_score": 0.7039357423782349, "token_count": 887, "dump": "CC-MAIN-2020-16", "global_id": "webtext-fineweb__CC-MAIN-2020-16__0__86993277", "lang": "en", "text": "Metall. Res. Technol.\nVolume 117, Number 1, 2020\n|Number of page(s)||7|\n|Published online||03 January 2020|\n- R.R. Boyer, Aerospace applications of beta titanium alloys, JOM, 20–23 (1994) [CrossRef] [Google Scholar]\n- H. Mishra, P. Ghosal, T.K. Nandy, et al., Influence of Fe and Ni on creep of near α–Ti alloy IMI834, Mater. Sci. Eng. 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Toop, Extented Miedema’s model for solid solution formation of ternary alloys, Tran. ALME 233, 850–855 (1965) [Google Scholar]\n- F.R. Boer, R. Boom, A.R. Miedema, Enthalpies of formation of liquid and solid binary alloys based on 3d metals, Physica 101B, 294–319 (1980) [Google Scholar]\nCurrent usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.\nData correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.\nInitial download of the metrics may take a while.", "domain": "chemistry", "round": 3} +{"url": "https://www.indexindex.com/dentistry/aggressiveness-of-contemporary-selfetching-adhesives-174724.html", "date": "2022-11-26T18:46:02Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-49/segments/1669446708046.99/warc/CC-MAIN-20221126180719-20221126210719-00532.warc.gz", "language_score": 0.912696361541748, "token_count": 1108, "dump": "CC-MAIN-2022-49", "global_id": "webtext-fineweb__CC-MAIN-2022-49__0__37422851", "lang": "en", "text": "Author(s): Pashley DH, Tay FR\nObjectives: The aggressiveness of three self-etching adhesives on unground enamel was investigated. Ultrastructural features and microtensile bond strength were examined, first using these adhesives as both the etching and resin-infiltration components, and then examining their etching efficacy alone through substitution of the proprietary resins with the same control resins.\nMethods: For SEM examination, buccal, mid-coronal, unground enamel from human extracted bicuspids were etched with either Clearfil Mega Bond (Kuraray), Non-Rinse Conditioner (NRC; Dentsply DeTrey) or Prompt L-Pop (ESPE). Those in the control group were etched with 32% phosphoric acid (Bisco) for 15s. They were all rinsed off prior to examination of the etching efficacy. For TEM examination, the self-etching adhesives were used as recommended. Unground enamel treated with NRC were further bonded using Prime&Bond NT (Dentsply), while those in the etched, control group were bonded using All-Bond 2 (Bisco). Completely demineralized, resin replicas were embedded in epoxy resin for examination of the extent of resin infiltration. For microtensile bond strength evaluation, specimens were first etched and bonded using the self-etching adhesives. A second group of specimens were etched with the self-etching adhesives, rinsed but bonded using a control adhesive. Following restoration with Z100 (3M Dental Products), they were sectioned into beams of uniform cross-sectional areas and stressed to failure.\nResults: Etching patterns of aprismatic enamel, as revealed by SEM, and the subsurface hybrid layer morphology, as revealed by TEM, varied according to the aggressiveness of the self-etching adhesives. Clearfil Mega Bond exhibited the mildest etching patterns, while Prompt L-Pop produced an etching effect that approached that of the total-etch control group. Microtensile bond strength of the three experimental groups were all significantly lower than the control group, but not different from one another. When the self-etching adhesives were replaced with the control adhesive after etching, bond strengths of NRC/Prime&Bond NT and Prompt L-Pop were not significantly different from that of the control group, but were significantly higher than that of Clearfil Mega Bond.\nSignificance: Both etching efficacy and strength of the resins are important contributing factors in bonding of self-etching adhesives to unground enamel.\nReferred From: https://www.ncbi.nlm.nih.gov/pubmed/11445211\nAuthor(s): Van Meerbeek B, De Munck J, Yoshida Y, Inoue S, Vargas M, et al.\nAuthor(s): Miranda C, Prates LH, Vieira Rde S, Calvo MC\nAuthor(s): Yazici AR, Celik C, Ozgünaltay G, Dayangaç B\nAuthor(s): Paradella TC, Fava M\nAuthor(s): El Zohairy AA, Saber MH, Abdalla AI, Feilzer AJ\nAuthor(s): Hashimoto M, Ohno H, Yoshida E, Hori M, Sano H, et al.\nAuthor(s): Glasspoole EA, Erickson RL, Davidson CL\nAuthor(s): Beloica M, Goracci C, Carvalho CA, Radovic I, Margvelashvili M, et al.\nAuthor(s): Yazici AR, Yildirim Z, Ertan A, Ozgunaltay G, Dayangac B, et al.\nAuthor(s): Lopes GC, Marson FC, Vieira LC, de Caldeira AM, Baratieri LN\nAuthor(s): Ebrahimi SF, Shadman N, Abrishami A\nAuthor(s): Van Landuyt KL, Snauwaert J, De Munck J, Peumans M, Yoshida Y, et al.\nAuthor(s): Stockton LW, Tsang ST\nAuthor(s): Braga RR, Cesar PF, Gonzaga CC\nAuthor(s): Gallo JR, Comeaux R, Haines B, Xu X, Burgess JO\nAuthor(s): Atash R, Van den Abbeele A\nAuthor(s): Abdalla AI, El Zohairy AA, Abdel Mohsen MM, Feilzer AJ\nAuthor(s): Yoshida Y, Nagakane K, Fukuda R, Nakayama Y, Okazaki M, et al.\nAuthor(s): Nagayassu MP, Shintome LK, Arana-Chavez VE, Fava M\nAuthor(s): Marquezan M, da Silveira BL, Burnett LH Jr, Rodrigues CR, Kramer PF\nAuthor(s): Perdigão J, May KN Jr, Wilder AD Jr, Lopes M\nAuthor(s): Tezvergil A, Lassila LV, Vallittu PK", "domain": "chemistry", "round": 3} +{"url": "https://www.vectem.ro/en/dermatocosmetics/prots-ud/prots-ud-35", "date": "2023-06-05T23:08:47Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-23/segments/1685224652184.68/warc/CC-MAIN-20230605221713-20230606011713-00248.warc.gz", "language_score": 0.8794771432876587, "token_count": 506, "dump": "CC-MAIN-2023-23", "global_id": "webtext-fineweb__CC-MAIN-2023-23__0__47587233", "lang": "en", "text": "Prots-ud 35 cream protects the skin of the hands before starting various activities and helps to recover it from various external aggressions, especially after contact with water, detergents or harmful substances.\nProts-ud 35 cream contains hydrolyzed collagen, which nourishes and protects the skin and a base with a high concentration of lipids and glycerin, which helps to rebuild the hydrolipidic layer of the skin and maintain hydration. After using the cream, the skin increases its strength and flexibility, and its appearance improves, becoming softer and more velvety.\nIn the case of people with dry, fragile skin or prone to various diseases, the use of Prots-ud 35 provides protection and visibly improves the appearance of the hands.\nFor activities that require contact with less aggressive substances, Prots-ud 35 is usually enough to protect the skin. When using gloves, the cream helps prevent maceration and prolongs the tolerance period.\nThe product is recommended for the protection and care of skin suffering from or subjected to: multiple washes, handling of materials and utensils, frequent disinfection, dryness caused by contact with dust, contact with water or detergents, dryness caused by cold, wind or sun, use frequency of gloves, cracks, roughness, dehydration.\nIt is recommended to use the product for: doctors, medical staff, housewives, domestic services, food handlers, carpenters, farmers, sailors, athletes, etc.\nApply the cream, massaging to help absorb into the skin. Use higher doses in vulnerable or affected areas. The product is used before starting work, to protect hands and after finishing work, to repair them. Apply the cream in the required amount and as often as you need. Use daily to keep your hands well groomed.\nPresentation: 40 ml tube\nAqua. C12-20 Acid PEG-8 Ester. Glycerin. Isopropyl Myristate. Palmitic Acid. Paraffinum Liquidum. Glyceryl Stearate. Cetyl Alcohol. Hydrolyzed Collagen. Phenoxyethanol. PEG-75 Stearate. Ceteth-20. Steareth-20. Parfum. Sodium Benzoate. Benzoic Acid. Limonene. Citral. Amyl Cinnamal. Hexyl Cinnamal. Geraniol. Citronellol.", "domain": "chemistry", "round": 3} +{"url": "https://medical.hudson.health/nad-infusions-for-withdrawal/?p=4855", "date": "2023-12-05T06:42:51Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100545.7/warc/CC-MAIN-20231205041842-20231205071842-00230.warc.gz", "language_score": 0.8248609304428101, "token_count": 1203, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__167234297", "lang": "en", "text": "NAD+ is everywhere. Everyone from podcasters to celebrities and, even, your coworkers are touting the benefits of NAD+ transfusions. As the popularity of NAD+ continues to climb across digital spheres—and IRL—the messaging around NAD+ could get murky, especially when it comes to conversations on how NAD+ and detoxification. To give you some clarity, we’re breaking down how NAD+ can be a powerful tool for people struggling with addiction.\nWhat is NAD+?\nNicotinamide adenine dinucleotide, NAD+ plays a crucial role in our existence. As a coenzyme found in all cells, it has the power to regulate processes like energy conversion, DNA repair, and immune system response.1,2 Over time our natural NAD+ levels diminish, ushering in age-related conditions and health concerns. While more and more people are seeking out NAD+ for its longevity-boosting benefits, demand for NAD+ as a detoxification tool is also growing.\nSince the 1960s researchers have touted the potential benefits of utilizing NAD+ supplementation to support individuals fighting withdrawals and recovering from substance abuse.4 Here’s how it can help:\nRestores depleted levels of NAD+\nIt’s not just age that can impact our NAD+ stores. Substance abuse, especially compounded over long periods of time, can deplete NAD+ levels by contributing to more oxidative stress and inflammation, which leads to cellular dysfunction and cellular death. Without adequate levels of NAD+ it’s increasingly difficult for body systems to operate at optimal levels.\nProtects against neurotoxicity\nNeurotoxicity refers to natural or man-made toxic substances that cause damage to the brain or nervous system. Substances like alcohol are proven neurotoxins and especially damaging to brain health and function.5 NAD+ has been shown to protect against neurotoxicity by activating enzymes involved in DNA repair and reducing oxidative stress in the brain.\nAmeliorates painful withdrawal symptoms\nWithdrawal periods result in physical and mental anguish, but NAD+ supplementation may abate this discomfort. Pioneering studies from 1961 showed the positive effects of NAD+ on withdrawal symptoms, and more recent studies are confirming reductions in craving, anxiety, and depression.4,6 During withdrawal from drugs or alcohol, the body is often under significant physiological stress, and the demand for ATP production increases. ATP is the primary energy source for cells and is critical for maintaining cellular function and survival. If ATP levels are depleted, it can contribute to the symptoms of withdrawal, including fatigue, weakness, and cognitive impairment.7\nReady to experience the power of NAD+ for yourself. Schedule your NAD+ infusion here.\n1.Cantó C, Menzies KJ, Auwerx J. NAD(+) Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus. Cell Metab. 2015 Jul 7;22(1):31-53. doi: 10.1016/j.cmet.2015.05.023. Epub 2015 Jun 25. PMID: 26118927; PMCID: PMC4487780.\n2.Covarrubias AJ, Perrone R, Grozio A, Verdin E. NAD+ metabolism and its roles in cellular processes during ageing. Nat Rev Mol Cell Biol. 2021 Feb;22(2):119-141. doi: 10.1038/s41580-020-00313-x. Epub 2020 Dec 22. PMID: 33353981; PMCID: PMC7963035.\n3. Braidy N, Villalva MD, van Eeden S. Sobriety and Satiety: Is NAD+ the Answer? Antioxidants (Basel). 2020 May 14;9(5):425. doi: 10.3390/antiox9050425. PMID: 32423100; PMCID: PMC7278809.\n4. O’HOLLAREN P. Diphosphopyridine nucleotide in the prevention, diagnosis and treatment of drug addiction. A preliminary report. West J Surg Obstet Gynecol. 1961 May-Jun;69:213-5. PMID: 13730082.\n5. 10th Special Report to the U.S. Congress on Alcohol and Health. National Institutes of Health, June 2000, https://pubs.niaaa.nih.gov/publications/10report/chap02e.pdf.\n6. Blum K, Han D, Baron D, Kazmi S, Elman I, Gomez LL, Gondre-Lewis MC, Thanos PK, Braverman ER, Badgaiyan RD. Nicotinamide Adenine Dinucleotide (NAD+) and Enkephalinase Inhibition (IV1114589NAD) Infusions Significantly Attenuate Psychiatric Burden Sequalae in Substance Use Disorder (SUD) in Fifty Cases. Curr Psychiatry Res Rev. 2022 Jul;18(2):125-143. doi: 10.2174/2666082218666220527114427. Epub 2022 Jun 21. PMID: 36118157; PMCID: PMC9474872.\n7. Cuenoud B, Ipek Ö, Shevlyakova M, Beaumont M, Cunnane SC, Gruetter R, Xin L. Brain NAD Is Associated With ATP Energy Production and Membrane Phospholipid Turnover in Humans. Front Aging Neurosci. 2020 Dec 16;12:609517. doi: 10.3389/fnagi.2020.609517. PMID: 33390929; PMCID: PMC7772416.", "domain": "chemistry", "round": 3} +{"url": "https://researchprofiles.canberra.edu.au/en/publications/sulfur-biogeochemical-cycling-and-novel-fe-s-mineralization-pathw", "date": "2024-02-21T21:35:51Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707947473558.16/warc/CC-MAIN-20240221202132-20240221232132-00754.warc.gz", "language_score": 0.9420844912528992, "token_count": 678, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__144143295", "lang": "en", "text": "Sulfur biogeochemical cycling and associated Fe-S mineralization processes exert a major influence over acidity dynamics, electron flow and contaminant mobility in wetlands, benthic sediments and groundwater systems. While S biogeochemical cycling has been studied intensively in many environmental settings, relatively little direct information exists on S cycling in formerly drained wetlands that have been remediated via tidal re-flooding. This study focuses on a tidal wetland that was drained in the 1970s (causing severe soil and water acidification), and subsequently remediated by controlled re-flooding in 2002. We examine SO42- reduction rates and Fe-S mineralization at the tidal fringe, 7years after the commencement of re-flooding. The initial drainage of the wetland examined here caused in-situ pyrite (FeS2) oxidation, resulting in the drained soil layers being highly acidic and rich in SO42--bearing Fe(III) minerals, including jarosite (KFe3(SO4)2(OH)6). Tidal re-flooding has neutralized much of the previous acidity, with the pore-water pH now mostly spanning pH 5-7. The fastest rates of in-situ SO42- reduction (up to ~300nmolcm-3day-1) occur within the inter-tidal zone in the near-surface soil layers (to ~60cm below ground surface). The SO42- reduction rates correlate with pore-water dissolved organic C concentrations, thereby suggesting that electron donor supply was the predominant rate determining factor. Elemental S was a major short-term product of SO42- reduction, comprising up to 69% of reduced inorganic S in the near-surface soil layers. This enrichment in elemental S can be partly attributed to interactions between biogenic H2S and jarosite - a process that also contributed to enrichment in pore-water Fe2+ (up to 55mM) and SO42- (up to 50mM). The iron sulfide thiospinel, greigite (Fe3S4), was abundant in near-surface soil layers within the inter- to sub-tidal zone where tidal water level fluctuations created oscillatory redox conditions. There was evidence for relatively rapid pyrite re-formation within the re-flooded soil layers. However, the results indicate that pyrite re-formation has occurred mainly in the lower formerly drained soil layers, whereas the accumulation of elemental S and greigite has been confined towards the soil surface. The discovery that pyrite formation was spatially decoupled from that of elemental S and greigite challenges the concept that greigite is an essential precursor required for sedimentary pyrite formation. In fact, the results suggest that greigite and pyrite may represent distinct end-points of divergent Fe-S mineralization pathways. Overall, this study highlights novel aspects of Fe-S mineralization within tidal wetlands that have been drained and re-flooded, in contrast to normal, undisturbed tidal wetlands. As such, the long-term biogeochemical trajectory of drained and acidified wetlands that are remediated by tidal re-flooding cannot be predicted from the well-studied behaviour of normal tidal wetlands.", "domain": "chemistry", "round": 3} +{"url": "https://www.indexindex.com/natural-products-chemistry-research/polymerization-of-human-sickle-cell-haemoglobin-hbs-in-the-presence-of-three-antimalarial-drugs-677221.html", "date": "2023-10-02T16:58:01Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233511002.91/warc/CC-MAIN-20231002164819-20231002194819-00478.warc.gz", "language_score": 0.8012968301773071, "token_count": 721, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__238679489", "lang": "en", "text": "Author(s): Chikezie PC, Chikezie CM, Amaragbulem PI\nTo study the capacity of antimalarial drugs to interfere with polymerization of sickle cell haemoglobin (HbS), in vitro polymerization was induced by incubating erythrocyte haemolysate of HbS with 2 g% sodium metabisulphite (Na2S2O5) in the presence of 2 mg% concentration of three (3) separate antimalarial drugs (CoartemTM, Quinine, and Chloroquine phosphate). Spectrophotometric method was used to ascertain the level of polymerization of HbS at a regular interval of 30 seconds for a period of 180 seconds at extinction coefficient (λmax) of 700nm. The level of polymerization was expressed in percentage of the absorbance of control sample at the 180th second. The three antimalarial drugs caused significant (p<0.05) reduction in HbS polymerization in the following ranges: CoartemTM (17.05-31.07%), Quinine (13.95-28.85%) and Chloroquine phosphate (10.85-33.01%). These results indicated the feasibility of the three drugs to retard HbS polymerization and as apparent potential candidates for therapy and management of sickle cell disease.\nAuthor(s): Afolabi IS, Osikoya IO, Fajimi OD, Usoro PI, Ogunleye DO, et al.\nAuthor(s): Olufunmilayo EA, Adelodun LK, Oladimeji PR, Lateef SK\nAuthor(s): GBD 2013 Mortality and Causes of Death, Collaborators\nAuthor(s): Diallo D, Tchernia G\nAuthor(s): Kunle OF, Egharevba HO\nAuthor(s): Sofowora EA, Isaac-Sodeye WA, Ogunkoya LO\nAuthor(s): RohiniManuja, ShikhaSachdeva, Akash Jain, Jasmine Chaudhary\nAuthor(s): Zaugg RH, Walder JA, Klotz IM\nAuthor(s): Abraham DJ, Mehanna AS, Wireko FC, Whitney J, Thomas RP, et al.\nAuthor(s): Elekwa I, Monanu MO, Anosike EO\nAuthor(s): Elujoba AA, Nagels L, Sofowora A, VanDongen W\nAuthor(s): Walder JA, Zaugg RH, Iwaoka RS, Watkin WG, Klotz IM\nAuthor(s): Xu AS, Macdonald JM, Labotka RJ, London RE\nAuthor(s): Fasanmade AA, Olaniyi AA, Ab-Yisak W\nAuthor(s): Abraham DJ, Gazze DM, Kennedy PE, Mokotoff M\nAuthor(s): Ouattara B, Jansen O, Angenot L, Guissou IP, Frédérich M, et al.\nAuthor(s): Wambebe C, Khamofu H, Momoh JA, Ekpeyong M, Audu BS, et al.\nAuthor(s): Sofowora EA, Isaacs WA\nAuthor(s): OgodaOnah J, Akubue PI, Okide GB", "domain": "chemistry", "round": 3} +{"url": "https://www.e3s-conferences.org/articles/e3sconf/ref/2021/78/e3sconf_ri2c2021_02019/e3sconf_ri2c2021_02019.html", "date": "2021-09-18T12:55:22Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-39/segments/1631780056476.66/warc/CC-MAIN-20210918123546-20210918153546-00233.warc.gz", "language_score": 0.6723658442497253, "token_count": 1215, "dump": "CC-MAIN-2021-39", "global_id": "webtext-fineweb__CC-MAIN-2021-39__0__169003524", "lang": "en", "text": "E3S Web Conf.\nVolume 302, 20212021 Research, Invention, and Innovation Congress (RI2C 2021)\n|Number of page(s)||6|\n|Section||Environmental Science and Engineering|\n|Published online||10 September 2021|\n- T.M. Letcher, Plastic waste and recycling : Environmental Impact, Societal, Issues, Prevention, and Solutions (Academic Press, London, 2020) [Google Scholar]\n- V.A. Szabó, G. Dogossy, Investigation of flame retardant rPET foam, Periodic Polytechnica Mechanical Engineering, 2019 [Google Scholar]\n- P. Kongsupapkul, K. Cheenkachorn, S. Tontisirin, Effects of MgO-ZSM-23 zeolite catalyst on the pyrolysis of PET bottle waste, KMUTNB international journal of applied science, 10, 3 (2017) : 205–211. [Google Scholar]\n- S. Makkam, W. Piewjan, W. Harnnarongchai, The effect of chain extender on rheological properties of recycled poly (ethylene terephthalate), RMUTP Research Journal Humanities and Social Sciences, 8, 2 (2014) : 70–80. [Google Scholar]\n- C. Fan, C. Wan, F. Gao, C. Huang, Z. Xi, Z. Xu, L. Zhao, T. Liu, Extrusion foaming of poly(ethylene terephthalate) with carbon dioxide based on rheology analysis, Journal of Cellular Plastics, 0, 0 (2015) : 1-22 [Google Scholar]\n- S. Yao, T. Guo, T. Liu, Z. Xi, Z. Xu, L. Zhao, Good extrusion foaming performance of long-chain branched PET induced by its enhanced crystallization property, Journal of Applied Polymer Science, (2020) [Google Scholar]\n- F. Ronkay, B. Molnár, F. Szalay, D. Nagy, B. Bodzay, I. E. Sajó, K. Bocz, Development of flameretarded nanocomposites from recycled PET bottles for the electronics industry, Polymer, 11, 233 (2019) [Google Scholar]\n- L. Incarnato, L. Scarfalo, L. Maio, D. Acierno, Structure and rheology of recycled PET modified by reactive extrusion, Polymer, 41, 18 (2000): 68256831 [Google Scholar]\n- R. Assadi, X. Colin, J. Verdu, Irreversible structure changes during PET recycling by extrusion, Polymers, 45, 13 (2004) : 4403-4412 [Google Scholar]\n- L.K. Nait-Ali, X. Colin, A. Bergeret, Kinetic analysis and modelling of PET macromolecular changes during its mechanical recycling by extrusion, Polymer Degradation and Stability, 96, 2 (2011) : 236-246 [Google Scholar]\n- F. Awaja, D. Pavel, Recycling of PET, European Polymer Journal, 41, 7 (2005) : 1453-1477 [Google Scholar]\n- V.A. SzabÓ, G. Dogossy, Structure and properties of closed-cell foam prepared from rPET, IOP Conf. Series: Materials Science and Engineering, 426 (2018): 012043 [Google Scholar]\n- M. Aksit, S. Gröschel, U. Kuhn, A. Aksit, K. Kreger, H-W. Schmidt, V. Altstädt, Low-density polybutylene terephthalate foams with enhanced compressive strength via a reactive-extrusion process, Polymers, 12, 2021 (2020) [Google Scholar]\n- S. Isarankura Na Ayutthaya, J. Wootthikanokkhan, Investigation of the photodegradation behaviors of an ethylene/vinyl acetate copolymer solar cell encapsulant and effects of antioxidants on the photostability of the material, Journal of Applied Polymer Science, 107 (2008) : 3853-3863 [Google Scholar]\n- A. Gooneie, P. Simonetti, K. Salmeia, S. Gaan, R. Hufenus, M. Heuberger, Enhanced PET processing with organophosphorus additive : Flame retardant products with added-value for recycling, Polymer Degradation and Stability, 160 (2019) : 218-228 [Google Scholar]\n- C. Huang, X. Dang, R. Bei, Y. Zhao, C. Li, Q. Chen, S. Wang, Effect of SiOx layer on preventing the migration of plasticizer and antioxidant from polyethylene terephthalate films, Iranian Polymer Journal, 28 (2019) : 173-182 [Google Scholar]\n- M. Villalobos, A. Awojulu, G. Greeley, G. Turco, G. Deeter, Oligomer chain extenders for economic reprocessing and recycling of condensation plastics, Energy, 31, 15 (2006) : 3272-3234 [Google Scholar]\nCurrent usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.\nData correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.\nInitial download of the metrics may take a while.", "domain": "chemistry", "round": 3} +{"url": "http://en.cnlvgong.cn/news_detail/3747433.html", "date": "2024-02-28T19:41:04Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707947474744.31/warc/CC-MAIN-20240228175828-20240228205828-00670.warc.gz", "language_score": 0.8807892799377441, "token_count": 686, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__155153669", "lang": "en", "text": "Lvgong machinery official website introduces the three advantages of reagent filling machine\nWuhan Lugong machinery official website introduces the three advantages of reagent filling machine. With the prevalence of medical self-test diagnostic reagents, more and more enterprises begin to contact automatic machinery such as reagent filling machine. Compared with labor, mechanized assembly line saves not only labor cost, but also greatly improves output. So, what are the advantages of reagent filling machine? Next, the manufacturer of Lugong reagent filling machine will give you a detailed introduction.\nWuhan Lugong machinery official website introduces the three advantages of reagent filling machine\n1. Reagent filling machine can precisely and quantitatively reduce the material loss of reagent\nLugong reagent filling machine manufacturer pointed out that the reagent filling machine uses a peristaltic pump for reagent filling, which can accurately quantify the reagent liquid. The whole operation process is controllable, making the operation easier and convenient for operators. At the same time, because the filling amount of reagent is set, the material loss of reagent is greatly reduced and the material cost is saved to a certain extent.\n2. The whole process automation system of reagent filling machine reduces manual errors and labor costs\nLugong reagent filling machine manufacturer pointed out that the whole process of reagent filling machine is an automatic system. Only by setting various parameters, it can automatically complete a series of assembly lines such as reagent filling, sealing and coding (date), which not only reduces the mistakes of human operation to a certain extent, but also greatly saves labor costs.\n3. The reagent filling machine has multiple functions\nThe function of reagent filling machine is very powerful. It can not only fill pharmaceutical industries such as reagents, but also fill food, daily chemical, chemical and other industries. One machine can be used for multiple purposes only by changing the mold suitable for its own products. The filling machine can automatically fill liquid, powder, particles and other products, and can adjust the parameters of the control panel according to different products.\nWuhan Lugong machinery official website introduces the three advantages of reagent filling machine. The above contents have been introduced in detail for you. You must have a certain understanding of reagent filling machine. Here, Xiaobian would also like to remind you that before purchasing reagent filling machine, please be sure to choose a regular and professional reagent filling machine manufacturer.\nWhat are the current problems encountered by the manufacturing industry?\n01. High intensity of physical labor and high turnover rate\n02. Labor efficiency is low, and the later operation cannot keep up with the front-end production\n03. Manual work is difficult to recruit, and the labor cost is high\n04. The error rate of operators is high, which is easy to cause huge losses\n05. The workshop is messy and there are various potential safety hazards\n06. Waste production space and increase unnecessary costs\nOne stop packaging machinery solution\nOne bag count line\n1-N docking stations\nArtificial intelligence packaging machine\nThe weight of each package meets the range\nThe precision of each large package is more than 99.9%\nA bag counting line for 20 machinesOnly 2-3 people are required to operateSave 80% - 90% labor\nHigh cost performance\nOne year to return", "domain": "chemistry", "round": 3} +{"url": "https://www.researchgate.net/researcher/64437446_Jun_Zhang", "date": "2016-02-10T13:30:55Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2016-07/segments/1454701159376.39/warc/CC-MAIN-20160205193919-00282-ip-10-236-182-209.ec2.internal.warc.gz", "language_score": 0.9241205453872681, "token_count": 445, "dump": "CC-MAIN-2016-07", "global_id": "webtext-fineweb__CC-MAIN-2016-07__0__7040915", "lang": "en", "text": "[Show abstract][Hide abstract] ABSTRACT: Protein palmitoylation is the post-translational addition of the 16-carbon fatty acid palmitate to specific cysteine residues by a labile thioester linkage. Palmitoylation is mediated by a family of at least 23 palmitoyl acyltransferases (PATs) characterized by an Asp-His-His-Cys (DHHC) motif. Many palmitoylated proteins have been identified, but PAT-substrate relationships are mostly unknown. Here we present a method called palmitoyl-cysteine isolation capture and analysis (or PICA) to identify PAT-substrate relationships in a living vertebrate system and demonstrate its effectiveness by identifying CKAP4/p63 as a substrate of DHHC2, a putative tumor suppressor.\n[Show abstract][Hide abstract] ABSTRACT: The addition of a lipid moiety to a protein increases its hydrophobicity and subsequently its attraction to lipophilic environments like membranes. Indeed most lipid-modified proteins are localized to membranes where they associate with multiprotein signaling complexes. Acylation and prenylation are the two common categories of lipidation. The enzymology and pharmacology of prenylation are well understood but relatively very little is known about palmitoylation, the most common form of acylation. One distinguishing characteristic of palmitoylation is that it is a dynamic modification. To understand more about how palmitoylation is regulated, we fused palmitoylation substrates to fluorescent proteins and reported their subcellular distribution and trafficking. We used automated high-throughput fluorescence microscopy and a specialized computer algorithm to image and measure the fraction of palmitoylation reporter on the plasma membrane versus the cytoplasm. Using this system we determined the residence half-life of palmitate on the dipalmitoyl substrate peptide from GAP43 as well as the EC(50) for 2-bromopalmitate, a common inhibitor of palmitoylation.\nNo preview · Article · Feb 2006 · Methods in Enzymology", "domain": "chemistry", "round": 3} +{"url": "https://openmaterialssciencejournal.com/VOLUME/5/PAGE/78/ABSTRACT/", "date": "2020-07-07T00:16:42Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-29/segments/1593655890566.2/warc/CC-MAIN-20200706222442-20200707012442-00399.warc.gz", "language_score": 0.8794175386428833, "token_count": 479, "dump": "CC-MAIN-2020-29", "global_id": "webtext-fineweb__CC-MAIN-2020-29__0__153018532", "lang": "en", "text": "Purification and Identification of a Natural Lectin from the Seed of Peanut Arachis hypogaea\nJie Sun*, Qing-li Yang, jie Bi, Chu-shu Zhang, Li-na Yu, Feng Zhu\nIdentifiers and Pagination:Year: 2011\nFirst Page: 78\nLast Page: 82\nPublisher Id: TOMSJ-5-78\nArticle History:Received Date: 28/9/2010\nRevision Received Date: 5/11/2010\nAcceptance Date: 22/12/2010\nElectronic publication date: 02/5/2011\nCollection year: 2011\nopen-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.\nA natural lectin from the seed of peanut Arachis hypogaea was purified by singlestep affinity chromatography using galactoside-coupled agarose. The native molecular mass of purified A. hypogaea lectin (PN-L) was 29 kDa. The lectin PN-L was detected for agglutinating activity, glycoinhibiting action and thermostability. The influence of pH on those activities was also tested. The results showed that PN-L could not agglutinate three kinds of human erythrocytes. But it showed a strong affinity to human A, B and O erythrocytes (RBC) treated by neuraminidase. Agglutinating activity of PN-L to neuraminidase treated human O erythrocytes was inhibited by lactose, raffinose, melibiose and D-galactose. The agglutinating activity of peanut seed lectin was stable up to 55°C and at pH 5.0-11.0. The results of MALDI-TOFTOF analysis indicated that the protein PN-L showed highly homology with the Peanut Lectin Chain A protein (gi|1942899).", "domain": "chemistry", "round": 3} +{"url": "https://www.ceramic-tilegrout.com/sale-13281970-anti-mould-stain-resistant-mosaic-sparkle-sanded-tile-grout.html", "date": "2023-01-31T20:32:05Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-06/segments/1674764499890.39/warc/CC-MAIN-20230131190543-20230131220543-00179.warc.gz", "language_score": 0.7212384343147278, "token_count": 934, "dump": "CC-MAIN-2023-06", "global_id": "webtext-fineweb__CC-MAIN-2023-06__0__303211698", "lang": "en", "text": "|Place of Origin:||CHINA|\n|Certification:||CE | RoHS | GB/T19001-2016/ISO 9001:2015|\n|Packaging Details:||Plastic Double Tube | Paper Box/pieces|\n|Supply Ability:||20million pieces / year|\n|Material:||Epoxy Resin Polymer + High-grade Pigments And Special Additives||Classification:||Two Component Epoxy Tile Grout|\n|Other Names:||Epoxy Grout | Epoxy Tile Grout | Ceramic Tile Grout | Tile Sealant||Color:||Matte | Sand|\n|Shelf Life:||24 Months||Application:||Ceramic Tile | Marble | Stone Etc Joint Filling, Beatification|\n|Packing:||2.5kg/barrel, 5kg/barrel||Appearance:||Smooth Paste|\n|Feature:||Anti-mildew | Stain Resistance | Waterproof | Durable | Easy To Clean | Easy Grouting||Keywords:||Epoxy Tile Grout | Epoxy Grout | Ready To Go Grout | Tile Sealant|\nMosaic Sparkle Sanded Tile Grout,\nStain Resistant Sanded Tile Grout,\nAnti Mould waterproof epoxy grout\nMOSAIC SPARKLE TILE GROUT, CEMENTITIOUS EPOXY, SCRAPE GROUTING, STAIN RESISTANCE, ANTI MOULD\nPerflex Epoxy Mortar Tile Grout P-10 is a two-component epoxy mortar grout for tile joint grouting. Part A is composed of high-tech polymer epoxy resin, fine aggregates, high-grade pigments/metallic and specific organic additives. Part B is composed of innovated organic catalyst. Once mixed together, it has super high performance of mechanical and chemical resistance, especially It’s the most efficient grouting way for mosaic tile. Furthermore, it can be used as adhesive to tiling the ceramic tile, quartz, stone, etc materials.\nPerflex Epoxy Mortar Grout P-20 is suitable for bonding, filling and beautifying the joint of ceramic tile, quartz, stone, etc building materials in those area like ceramic tile floor, ceramic tile wall, washbasin, bathtub, toilet, kitchen table, door-crossing stone, etc.\nIt has high bonding strength, excellent physical properties such as non-sagging, tear/scratch/wear resistance. After curing, it is super anti-mildew, anti-bacterial, stain resistance, waterproof, moisture-proof, colorful, durable, smooth as porcelain, hard as diamond, natural as sanded cement, easy to clean, etc. The construction is very simple and convenient.\n|Testing Item||Resin A||Hardener B|\n|Appearance||Semi-fluid liquid||Thixotropic paste|\n|Blend Ratio(by volume)||A : B = 1 : 0.09|\n|Working time(25℃*min)||30 min|\n|Colloidal fluidity after blending||Thixotropic fluid|\n|Wear Resistance (750 g.500 r)/g||0.050|\n|Sagging after blending?||No sagging|\n|Tensile Shear Strength/MPa||Standard condition||≥5.0|\n|High/low temperature switch||≥3.0|\n|Water absorbent 25℃24 hour(%)||＜0.2|\n|Waterproof / 24h||No change|\n|Chemical Resistance / 2h||No change|\n|Stain Resistance (Vinegar, soy, oil)/ 1h||No change|\n|Testing condition: 21-25℃,relative humidity 45-55%. Constructed by caulking gun.|\n1. After the m\n24 months if the product is stored in a dry and cool place away from light.\nContact Person: Laura", "domain": "chemistry", "round": 3} +{"url": "http://www.barnesandnoble.com/w/encyclopedia-of-toxicology-philip-wexler/1003527871?ean=9780122272202&itm=1&usri=shayne+c.+gad", "date": "2017-01-22T02:06:23Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-04/segments/1484560281331.15/warc/CC-MAIN-20170116095121-00237-ip-10-171-10-70.ec2.internal.warc.gz", "language_score": 0.7087278962135315, "token_count": 932, "dump": "CC-MAIN-2017-04", "global_id": "webtext-fineweb__CC-MAIN-2017-04__0__248809519", "lang": "en", "text": "Encyclopedia of Toxicology (3 vols.)by Philip Wexler (Editor), Shayne C. Gad\nThe Encyclopedia of Toxicology provides a comprehensive collection of concise and readable explanations of basic principles in toxicology and the potential hazards of chemicals. Written by highly qualified contributors and containing a broad selection of topics, the Encyclopedia is of value to both toxicologists and non-toxicologists, including physicians, attorneys, regulators, safety managers, and environmental engineers-anyone whose work involves the health and safety issues of common and uncommon substances. The Encyclopedia of Toxicology plays a critical role at the intermediate level by offering more detail than a dictionary while remaining accessible to the generalist in risk assessment, regulation, and consulting. The reference work includes entries related to research and clinical toxicology, risk assessment, ecotoxicology, epidemiology, radiation, noise, information resources, organizations, and education. With more than 750 entries, extensive cross-references, a detailed index, and numerous references to primary and secondary literature, the Encyclopedia will be an indispensable resource.\nFEATURED ARTICLES A-B: Absorption. Academy of Toxicological Sciences. ACE Inhibitors. Acenaphthene. Acetaldehyde. Acetaminophen. Acetic Acid. Acetone. Acetonitrile. Acetylaminofluorene. Acetylcholine. Acetylene. Acetylsalicylic Acid. Acids. Acids, Inorganic. Aconitum Species. Acrolein. Acrylamide. Acrylic Acid. Acrylonitrile. Adiponitrile. Aerosols. A-esterase. Aflatoxin. Agency for Toxic Substances and Disease Registry. Alachlor. Alar. Albuterol. Aldicarb. Aldrin. Algae.Alkalies. Alkyl Halides. Alpha-Methylfentanyl. Alpha-Naphthyl Thiourea. Aluminum (Al). Aluminum Phosphide. Amdro. American Academy of Clinical Toxicology. American Association of Poison Control Centers. American Board of Toxicology. American College of Medical Toxicology. American College of Toxicology. American Conference of Governmental Industrial Hygienists. Ames Test. Aminoglycosides. Amiodarone. Ammonia. Ammonium Nitrate. Ammonium Perchlorate. Amphetamine. Amphibians. Amyl Nitrate. Analytical Toxicology. Androgens. Animal Models. Anthracene. Anticholinergics. Antimony (Sb). Anxiolytics. Aramite. Arsenic (As). Arum. Asbestos. Ascorbic Acid. Aspartame. Astemizole. Atrazine. Atropine. Avermectin. Azinphos-Methyl. Bacillus cereus. BAL. Baneberry. Barbiturates, Long-Acting. Barbiturates, Short-Acting. Barium (Ba). Baygon. BCNU. Behavioral Toxicology. Belladonna Alkaloids. Benadryl. Benomyl. Benz(a)anthracene. Benzene. Benzene Hexachloride. Benzidine. Benzo(a)pyrene. Benzodiazepines. Benzyl Alcohol. Benzyl Benzoate. Beryllium (Be). Beta Blockers. Biguanides. Bioaccumulation. Bioconcentration. Biomagnification. Biomarkers, Environmental. Biomarkers, Human Health. Biotransformation. Bismuth (Bi). Bleach. Blood. Boric Acid. Boron (B). Botulinum Toxin. Brodifacoum. Bromine. Bromobenzene. Bromoform. Buckthorn. Butadiene, 1,3-. Butane. Butter Yellow. Butyl Ether. Butyl Ethyl Ether. Butyl Methyl Ether. Butyl Nitrite. Butylamines. Butylated Hydroxyanisole. Butylated Hydroxytoluene. Butyraldehyde, n-. Butyric Acid. Butyronitrile. Butyrophenones.\n- Elsevier Science & Technology Books\n- Publication date:\n- Product dimensions:\n- 9.71(w) x 11.99(h) x 5.07(d)\nMost Helpful Customer Reviews\nSee all customer reviews", "domain": "chemistry", "round": 3} +{"url": "https://hotdinners.ru/newly-discovered-international--dating-6106.html", "date": "2020-10-20T17:00:00Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-45/segments/1603107874026.22/warc/CC-MAIN-20201020162922-20201020192922-00673.warc.gz", "language_score": 0.9573101997375488, "token_count": 331, "dump": "CC-MAIN-2020-45", "global_id": "webtext-fineweb__CC-MAIN-2020-45__0__118429074", "lang": "en", "text": "Newly discovered international dating\nHe reasoned that a state of equilibrium must exist wherein the rate of carbon-14 production was equal to its rate of decay, dating back millennia.(Fortunately for him, this was later proven to be generally true.) For the second factor, it would be necessary to estimate the overall amount carbon-14 and compare this against all other isotopes of carbon.To test the technique, Libby’s group applied the anti-coincidence counter to samples whose ages were already known.\nTop of page The “Curve of Knowns” compared the known age of historical artifacts associated with the Bible, Pompeii, and Egyptian dynasties with their age as determined by radiocarbon dating.\nFinally, Libby had a method to put his concept into practice. The circular arrangement of Geiger counters (center) detected radiation in samples while the thick metal shields on all sides were designed to reduce background radiation.\nThe concept of radiocarbon dating relied on the ready assumption that once an organism died, it would be cut off from the carbon cycle, thus creating a time-capsule with a steadily diminishing carbon-14 count.\nTop of page Carbon-14 was first discovered in 1940 by Martin Kamen (1913–2002) and Samuel Ruben (1913–1943), who created it artificially using a cyclotron accelerator at the University of California Radiation Laboratory in Berkeley.\nFurther research by Libby and others established its half-life as 5,568 years (later revised to 5,730 ± 40 years), providing another essential factor in Libby’s concept.", "domain": "chemistry", "round": 3} +{"url": "https://www.express.co.uk/news/science/1287983/ozone-layer-global-warming-mass-extinction-dinosaurs-Southampton", "date": "2021-08-04T23:42:30Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-31/segments/1627046155188.79/warc/CC-MAIN-20210804205700-20210804235700-00568.warc.gz", "language_score": 0.96238774061203, "token_count": 775, "dump": "CC-MAIN-2021-31", "global_id": "webtext-fineweb__CC-MAIN-2021-31__0__7200412", "lang": "en", "text": "Ozone layer: Animation shows hole form over the Arctic\nIt could have alarming implications for the way our current world is headed, regarding rising global temperatures. Researchers from the University of Southampton have been investigating an extinction event that occurred at the end of the Devonian geological period.\nDuring their study, they found evidence that plant spores from around the time had been damaged by UV radiation, suggesting that the Earth’s ozone layer was not providing sufficient protection from the sun’s deadly rays.\nWhile it is already known that ozone depletion could lead to an extinction event, the scientists were alarmed by the reason behind why the ozone depletion seemed to have occurred.\nThe researchers discovered that this particular ozone erasure could have been linked to global warming, which the scientists described as a “new mechanism for mass extinctions.”\nMass extinction events have occurred a number of times in Earth’s past, with known causes being asteroid impacts and large-scale volcanic eruptions, Phys.org reports.\nScientists warn global warming could lead to a disastrous ozone depletion.\nMany will associate the asteroid impact event as the one that led to the extinction of the dinosaurs.\nThe extinction event that the Southampton scientists were studying came after a period of rapid global warming after an ice age, Phys.org continues.\nAs part of their study, the researchers collected rocks from sites in Greenland as well as Bolivia in order to study any clues about what Earth conditions may have been like way back 360 million years ago.\nIndeed, these rocks held some clues as to what had been happening around the time of the Devonian period.\nThe researchers found that the rocks contained plant spores – which plants use to reproduce – that had been preserved within them for hundreds of millions of years.\nThey discovered that some of these spores appeared to have been damaged by something, noting that they had “malformed sculpture and pigmented walls”.\nThis sort of damage is similar to what would occur if the spores had been hit by high levels of ultraviolet light – also called UV rays – that are given off by the sun.\nThe researchers explained: “This indicates the temporary loss of the global protective ozone layer.”\nNASA Antarctica SHOCK: How scientists uncovered 'greatest discovery' [REVEALED]\nOzone layer is making a comeback and will be FULLY recovered by 2060 [INSIGHT]\nRise in ozone-layer damaging CFC-11 leaves scientists baffled [EXPLAINED]\nThis is because the ozone layer absorbs some of the UV light – a particular type called UBV – that travels from the sun to the Earth.\nThe US Environmental Protection Agency (EPA) notes that UVB light has been linked to skin cancer and can cause harm to crops and marine life.\nThe ozone layer is a part of Earth’s atmosphere located in the stratosphere between 9 and 18 miles up.\nProfessor Marshall, lead researcher for the team, said that “current estimates suggest we will reach similar global temperatures to those of 360 million years ago,” according to phys.org.\nHe added that this raises the possibility of another collapse in the ozone layer, which could have disastrous consequences for all life on Earth, including us.\nIn the study’s abstract, the team said: “ozone loss during rapid warming is an inherent Earth system process with the unavoidable conclusion that we should be alert for such an eventuality in the future warming world.”\nAs well as global warming, human activity is associated with the depletion of the Earth’s vital ozone layer.\nScientists have reported that a large ozone hole over the Antarctic is slowly beginning to recover amid international efforts to limit the amount of ozone-depleting substances belched out by mankind.", "domain": "chemistry", "round": 3} +{"url": "https://saemobilus.sae.org/content/801390/", "date": "2021-12-07T09:12:39Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-49/segments/1637964363337.27/warc/CC-MAIN-20211207075308-20211207105308-00114.warc.gz", "language_score": 0.8891263008117676, "token_count": 888, "dump": "CC-MAIN-2021-49", "global_id": "webtext-fineweb__CC-MAIN-2021-49__0__176024036", "lang": "en", "text": "This content is not included in your SAE MOBILUS subscription, or you are not logged in.\nTemporary Viscosity Loss in Shear Stability Testing\nISSN: 0148-7191, e-ISSN: 2688-3627\nPublished October 01, 1980 by SAE International in United States\nAnnotation ability available\nThe relationships between the permanent and temporary viscosity losses were examined for 43 oils at 100°C and 150°C. High-shear-rate viscosities were measured at a shear rate of 106 s-1 in a capillary viscometer for new oils and used oils. New oils that had been subjected to 20 cycles in the Fuel Injector Shear Stability Test were considered to be used oils in this program. There was no useful relationship between the temporary viscosity loss (difference between kinematic and high-shear-rate viscosities of new oil) and the permanent viscosity loss (difference between kinematic viscosities of new oil and of used oil). Also, there was no useful relationship between either the temporary or permanent losses alone and the combined loss (difference between kinematic viscosity of new oil and high-shear-rate viscosity of used oil.) There was, however, a relationship between the temporary loss and the permanent loss, used together, and the combined loss. This relationship makes it possible to estimate the combined viscosity loss without having to measure the high-shear-rate viscosity of the used oil.\nCitationAlexander, D. and Rein, S., \"Temporary Viscosity Loss in Shear Stability Testing,\" SAE Technical Paper 801390, 1980, https://doi.org/10.4271/801390.\n- Okrent E. H. “The Effect of Lubricant Viscosity and Composition on Engine Friction and Bearing Wear.” ASLE Trans. 4 1 97 108 1961\n- Davison E. D. Haviland M. L. “Lubricant Viscosity Effects on Passenger Car Fuel Economy.” SAE Paper 750675 1975\n- Bell J. C. Voisey M. A. “Some Relationships Between the Viscometric Properties of Motor Oils and Performance in European Engines.” SAE Paper 77037, published in SAE SP-416 (ASTM STP-6 21) “The Relationship Between Engine Oil Viscosity and Engine Performance - Part I,” SAE 1977\n- Badiali F. L. Cassiani Ingoni A. A. Pusateri G. “Friction Power Loss of Mineral and Synthetic Lubricants in a Running Engine-” SAE Paper 780376 , published in SAE SP-429 (ASTM STP-621-S2) “The Relationship Between Engine Oil Viscosity and Engine Performance -Part III,” SAE 1978\n- Waddey W. E. Pearce A. F. “Effects of Motor Oil Composition on Engine Wear.” SAE Paper 690774 1969\n- Spooren E. W. Rein S. W. Alexander D. L. “Assessment of Shear Stability Test Methods for European Engine Oils.” SAE Paper No. 790214 , published in SAE SP-460 (ASTM STP-621-S4) “The Relationship Between Engine Oil Viscosity and Engine Performance - Part V and Part VI,” SAE 1980\n- Rein S. W. Alexander D. L. “Development of a High Shear Rate Capillary Viscometer for Engine Oils.” SAE Paper No. 800363 , published in SAE SP-460 (ASTM STP-621-S4) SAE 1980\n- Behrens M. D. Rein S. W. Roth G. W. Roth G. W. Marshall H. T. “An Automated Fuel Injector Shear Stability. Test,” SAE Paper 680158 1968", "domain": "chemistry", "round": 3} +{"url": "http://www.astm.org/DIGITAL_LIBRARY/STP/SOURCE_PAGES/STP1335.htm", "date": "2015-05-03T13:52:50Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2015-18/segments/1430448950892.36/warc/CC-MAIN-20150501025550-00016-ip-10-235-10-82.ec2.internal.warc.gz", "language_score": 0.6741034388542175, "token_count": 688, "dump": "CC-MAIN-2015-18", "global_id": "webtext-fineweb__CC-MAIN-2015-18__0__162730439", "lang": "en", "text": "| ||Format||Pages||Price|| |\n|PDF (7.5M)||$115||  ADD TO CART|\n|Hardcopy (shipping and handling)||$115||  ADD TO CART|\n|Hardcopy + PDF Bundle - Save 25%\n(shipping and handling)\n|$172.50||  ADD TO CART|\nThe most current information on engine coolant technologies and testing requirements. 25 papers from the world's leading scientists in the field are divided among the following major categories:\nOrganic acid inhibition technology research covering an impressive sampling of organic preparations;\nState-of-the-art test methods on a wide range of metals and other surfaces;\nspecial requirements involved with heavy-duty coolant technology\nDevelopments in the growing field of engine coolant recycling technology;\nNew procedures and proposed alterations in engine coolant characteristics and quality improvement\nand improved efficient engine coolant service and disposal.\nAn invaluable resource for automotive and trucking manufacturers, vehicle service operators, municipal fleet managers, coolant formulators and manufacturers, and oil and chemical companies.\nComposition of Incipient Passivating Layers on Heat-Rejecting Aluminum in Carboxylate- and Silicate-Inhibited Coolants: Correlation with ASTM D 4340 Weight Losses\nMilitello M., Moylan T., Simko S., Wagner F.\nFleet Test Evaluation of Fully Formulated Heavy-Duty Coolant Technology Maintained with a Delayed-Release Filter Compared with Coolant Inhibited with a Nitrited Organic Acid Technology: An Interim Report\nAroyan S., Eaton E.\nEngine Coolant Technology, Performance, and Life for Light-Duty Applications\nListebarger J., Lockwood F., Meszaros L., Pfitzner K., Turcotte D.\nCopper-Triazole Interaction and Coolant Inhibitor Depletion\nBartley L., Fritz P., Pellet R., Taylor S., Van de Ven P.\nRapid Electrochemical Screening of Engine Coolants. Correlation of Electrochemical Potentiometric Measurements with ASTM D 1384 Glassware Corrosion Test\nDoucet G., Jackson J., Kriegel O., Passwater D., Prieto N.\nLong-Term Serviceability of Elastomers in Modern Engine Coolants\nBussem H., Farinella A., Hertz D.\nInfluence of Engine Coolant Composition on the Electrochemical Degradation Behavior of EPDM Radiator Hoses\nLievens S., Maes J., Vroomen G.\nScale and Deposits in High-Heat-Rejection Engines\nChen Y., Corbeels C., Hudgens R., Kershisnik E., Zehr R.\nOverview of Used Antifreeze and Industrial Glycol Recycling by Vacuum Distillation\nChan K., Frye D., Pourhassanian C.\nHeavy-duty Fleet Test Evaluation Of Recycled Engine Coolant\nFrost R., Woyciesjes P.\nMethods and Equipment for Engine Coolant Testing\nBeal R., McCracken S.\nDevelopment of an Extended-Service Coolant Filter\nHudgens R., Mitchell W.", "domain": "chemistry", "round": 3} +{"url": "https://escholarship.org/uc/item/9kk0r72c", "date": "2023-02-04T19:18:35Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-06/segments/1674764500151.93/warc/CC-MAIN-20230204173912-20230204203912-00372.warc.gz", "language_score": 0.8792363405227661, "token_count": 337, "dump": "CC-MAIN-2023-06", "global_id": "webtext-fineweb__CC-MAIN-2023-06__0__259014019", "lang": "en", "text": "Protein tyrosine phosphatase 1B regulates pyruvate kinase M2 tyrosine phosphorylation.\nPublished Web Locationhttps://doi.org/10.1074/jbc.m112.441469\nProtein-tyrosine phosphatase 1B (PTP1B) is a physiological regulator of glucose homeostasis and adiposity and is a drug target for the treatment of obesity and diabetes. Here we identify pyruvate kinase M2 (PKM2) as a novel PTP1B substrate in adipocytes. PTP1B deficiency leads to increased PKM2 total tyrosine and Tyr(105) phosphorylation in cultured adipocytes and in vivo. Substrate trapping and mutagenesis studies identify PKM2 Tyr-105 and Tyr-148 as key sites that mediate PTP1B-PKM2 interaction. In addition, in vitro analyses illustrate a direct effect of Tyr-105 phosphorylation on PKM2 activity in adipocytes. Importantly, PTP1B pharmacological inhibition increased PKM2 Tyr-105 phosphorylation and decreased PKM2 activity. Moreover, PKM2 Tyr-105 phosphorylation is regulated nutritionally, decreasing in adipose tissue depots after high-fat feeding. Further, decreased PKM2 Tyr-105 phosphorylation correlates with the development of glucose intolerance and insulin resistance in rodents, non-human primates, and humans. Together, these findings identify PKM2 as a novel substrate of PTP1B and provide new insights into the regulation of adipose PKM2 activity.", "domain": "chemistry", "round": 3} +{"url": "https://www.engineering.org.cn/en/top_journal_details/873846", "date": "2021-04-11T10:40:34Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-17/segments/1618038061820.19/warc/CC-MAIN-20210411085610-20210411115610-00595.warc.gz", "language_score": 0.926616370677948, "token_count": 339, "dump": "CC-MAIN-2021-17", "global_id": "webtext-fineweb__CC-MAIN-2021-17__0__166175004", "lang": "en", "text": "Journal of Cleaner Production\nXiao-yu Shang;Jiang-shan Li\nThe production of lightweight aggregates (LWAs) involves much energy consumption and emission of pollution during the sintering process. The increasing worldwide demand for functional concrete for use in modern construction has promoted this negative trend to a more serious level. This study reports an artificial lightweight capsule aggregates (CAs) based on an encapsulation technology from the viewpoint of green manufacturing. The novel CAs are composed of a fly ash-cement inorganic shell and sodium alginate organic core. A series of experiments were conducted to study the influences of the rotation rate, duration time, curing conditions and surface conditions for sodium alginate beads (SAB) on the physical and mechanical characteristics of the CAs. The results indicate that CAs with a wet density of 1340 kg/m, and corresponding crush strength of 2.46 MPa can be achieved. The CAs density can be further decreased by a third via sodium alginate dehydration. CAs with optimized performance can be synthesized by using a rotation rate of 150 rpm, duration time of 30 s and C/A ratio of 2.0. A low rotation rate and high duration time have a negative effect on the CAs characteristics. A saturated surface dry (SSD) condition process for the SAB was found to greatly contribute to the optimization of CAs density. Findings from this study can provide a novel and viable way to reuse industrial wastes and biomass resources to manufacture core-shell structured LWAs with stable and adjustable performance. These artificial LWAs have great application potential in the preparation of the advanced lightweight concrete.", "domain": "chemistry", "round": 3} +{"url": "https://ui.adsabs.harvard.edu/abs/1994PNAS...91.9175Y", "date": "2022-05-29T03:27:06Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-21/segments/1652663035797.93/warc/CC-MAIN-20220529011010-20220529041010-00536.warc.gz", "language_score": 0.9494057297706604, "token_count": 283, "dump": "CC-MAIN-2022-21", "global_id": "webtext-fineweb__CC-MAIN-2022-21__0__247519526", "lang": "en", "text": "Bruton tyrosine kinase (EC 184.108.40.206) [Btk, encoded by Btk in mice and BTK in humans (formerly known as atk, BPK, or emb)], which is variously mutated in chromosome X-linked agammaglobulinemia patients and X-linked immunodeficient (xid) mice, has the pleckstrin homology (PH) domain at its amino terminus. The PH domain of Btk expressed as a bacterial fusion protein directly interacts with protein kinase C in mast cell lysates. Evidence was obtained that Btk is physically associated with protein kinase C in intact murine mast cells as well. Both Ca(2+)-dependent (alpha, beta I, and beta II) and Ca(2+)-independent protein kinase C isoforms (epsilon and zeta) in mast cells interact with the PH domain of Btk in vitro, and protein kinase C beta I is associated with Btk in vivo. Btk served as a substrate of protein kinase C, and its enzymatic activity was down-regulated by protein kinase C-mediated phosphorylation. Furthermore, depletion or inhibition of protein kinase C with pharmacological agents resulted in an enhancement of the tyrosine phosphorylation of Btk induced by mast cell activation.", "domain": "chemistry", "round": 3} +{"url": "https://bioassaysys.com/urease-assay-kit/", "date": "2023-09-22T02:00:11Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233506320.28/warc/CC-MAIN-20230922002008-20230922032008-00871.warc.gz", "language_score": 0.8080114722251892, "token_count": 668, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__54081980", "lang": "en", "text": "If the standards have low OD values this could be caused by adding the reagents in the wrong order. It is critical to add reagent A first, mix, and then add reagent B. The color reaction is time and temperature dependent. The 30 minute incubation time is for room temperature (25°C). If the temperature is lower, you have to incubate longer to obtain the same OD values.\nWe have not tested feces samples ourselves and are not aware of any publications using this kit with stool samples, but believe it should work: We would suggest homogenizing the feces sample in a neutral buffer (e.g. PBS), urease is water soluble and will dissolve. Depending on the consistence of the sample, I would suggest starting with a 10:1 ratio of buffer to sample and homogenize the sample, e.g. by sonication. Then filter the sample to remove all larger particulates. After that, if necessary, add a centrifugation step (5 min at 15,000 x g) to remove smaller particulates. Only clear supernatant should be used in the assay.\nUse 0.5 g soil. Add 0.3 mL of 0.4mm glass beads, 500 µL of buffer. Vortex on high speed for 2 minutes, then centrifuge for 2 min at 12000 rpm, use 100 µL of the clear fluid and incubate with substrate at 37°C for 3 hours.\nJoerger RD, et al (2020) Effect of sodium bisulfate amendments on bacterial populations in broiler litter. Poultry Science.;99(11):5560-5571. Assay: Urease in chicken litter.\nWei, T., et al (2020). Chinese yellow rice wine processing with reduced ethyl carbamate formation by deleting transcriptional regulator dal80p in saccharomyces cerevisiae. Molecules (Basel, Switzerland), 25(16). Assay: Urease in yeast cells.\nLiu, Q. W., Liu, Q. Y., Li, J. Y., Wei, L., Ren, K. K., Zhang, X. C. & Xin, H. B. (2018). Therapeutic efficiency of human amniotic epithelial stem cell-derived functional hepatocyte-like cells in mice with acute hepatic failure. Stem cell research & therapy, 9(1), 321. Assay: Urea production in human cell culture media.\nWu, D (2015). Constitutive expression of the DUR1, 2 gene in an industrial yeast strain to minimize ethyl carbamate production during Chinese rice wine fermentation. FEMS Microbiology Letters 363(1): fnv214. Assay: Urease.\nZhang, T. et al (2015). Development of an Agrobacterium-mediated transformation system for the cold-adapted fungi Pseudogymnoascus destructans and P. pannorum. Fungal Genetics and Biology 81: 73-81. Assay: urease in fungus.\nTo find more recent publications, please click here.\nQuality and User-friendly • Expert Technical Support • Competitive Prices • Expansive Catalogue • Trusted Globally", "domain": "chemistry", "round": 3} +{"url": "https://www.bio-gems.com/recombinant-proteins/chemokines/sdf-cxcl12/recombinant-rat-sdf-1-cxcl12.html", "date": "2021-04-16T02:40:38Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-17/segments/1618038088471.40/warc/CC-MAIN-20210416012946-20210416042946-00454.warc.gz", "language_score": 0.7929099202156067, "token_count": 260, "dump": "CC-MAIN-2021-17", "global_id": "webtext-fineweb__CC-MAIN-2021-17__0__115362806", "lang": "en", "text": "Recombinant Rat SDF-1α (CXCL12)\nCatalog Number : 400-32A\nSDF-1α and β are stromal derived CXC chemokines, and signal through the CXCR4 receptor. SDF-1α and β chemoattract B and T cells, and have been shown to induce migration of CD34+ stem cells. Additionally, the SDF-1 proteins exert HIV suppressive activity in cells expressing the CXCR4 receptor. Recombinant rat SDF-1α is a 7.9 kDa protein containing 68 amino acid residues.\nAbove 98% as determined by SDS-PAGE Analysis.\nDetermined by its ability to chemoattract human peripheral blood monocytes using a concentration range of 50.0-100.0 ng/ml.\nKPVSLSYRC PCRFFESHV ARANVKHLK ILNTPNCAL QIVARLKSN NRQVCIDPK LKWIQEYLD KALNK\n|Research Interest:||Stem Cell Research, Cancer, Neurosciences|\n|Cell Type:||B Cells, T Cells, Stem Cells|\n|Protein Cross Reactivity:||Human|", "domain": "chemistry", "round": 3} +{"url": "https://biobender.com/2018/11/in-is-a-dimorphic-opportunistic-pathogen-which-in-turn-causes-a/", "date": "2023-02-08T03:30:34Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-06/segments/1674764500671.13/warc/CC-MAIN-20230208024856-20230208054856-00784.warc.gz", "language_score": 0.9565361142158508, "token_count": 1136, "dump": "CC-MAIN-2023-06", "global_id": "webtext-fineweb__CC-MAIN-2023-06__0__266415580", "lang": "en", "text": "In is a dimorphic opportunistic pathogen which in turn causes a multitude of infections which range from relatively focused an infection like superficial mycoses in generally healthy people to life-threatening systemic an infection candidiasis in people with weakened defense systems , . leaflet from the plasma membrane in and both in scientific and in lab induced azole-resistant strains of can be not homogeneous within their lipid structure. There are a few membrane regions which contain higher focus of ergosterol and sphingolipids , . These locations are more arranged than the remaining membrane because of a higher quantity of saturated acidity chains and so are as a result known as lipid rafts , . The compositions in lipid rafts are firmly packed structures which will make raft insoluble in nonionic detergents like Triton X-100 at low heat range . Because of this, lipid rafts may also be called detergent-resistant membranes (DRMs). Furthermore to stress (Desk 1) wherein one allele was fused using Rabbit Polyclonal to SSBP2 the GFP-cassette, while preserving the indigenous promoter sequence. The right fusion of and GFP in the RM-GFP strain was confirmed by PCR utilizing a primer set particular for and GFP (Amount S1). It’s been shown which the disruption of each one Biperiden HCl manufacture or two alleles in shown an increased awareness particularly to azoles . In today’s research, we discovered that the RM-GFP stress rendered very similar sensitivities to azoles including fluconazole and voriconazole using the wild-type stress (Amount 1), which indicated which the Rta2p-GFP was functionally portrayed in the changed stress. The Rta2p-GFP fluorescence was noticed to become unevenly within the cell surface area of changed live cells (Amount 2A). Furthermore, the changed cells had been co-stained with filipin, which Biperiden HCl manufacture includes been utilized to visualize membrane sterols . As noticeable in Amount 2B, the fluorescence of Rta2p-GFP and filipin staining had been co-localized in the plasma membrane of strains ( Desk 1 ) as dependant on place assays. strains including wild-type (RM1000), RM-GFP and strains had Biperiden HCl manufacture been discovered on YPD agar plates with or without different antifungal realtors at indicated concentrations. Plates had been incubated for 24 h at 35C. Open up in another window Amount 2 Evaluation of fluorescent proteins fusions in C. albicans.(A) Immunofluorescence mapping of Rta2p-GFP. Overlay (still left), fluorescence (center) and shiny field (correct) pictures are shown separately. (B) Co-localization of ergosterol-rich domains stained by filipin and Rta2p-GFP of after contact with FLC (8 g/ml) or myriocin (0.4 g/ml) for 16 h. Pub, 5 m. Desk 1 strains found in this research. cells demonstrated that Rta2p-GFP was primarily within the intracellular compartments (Number 2C). An identical observation was also produced when myriocin was given to inhibit the first rung on the ladder biosynthesis of sphingolipid , another main constituent of lipid rafts in (Number 2C). Consequently, these data imply Rta2p may be connected with lipid rafts in cells had been analyzed on Traditional western blots probed with antibodies against Pma1p and Gas1p homologue. (F) Membranes protein extracted from complemented cells had been analyzed on Traditional western blots probed with antibodies against Pma1p and Gas1p homologue. Representative data are proven from three unbiased experiments. It’s been well noted that raft association of Pma1p and Gas1p homologue towards the plasma membrane are influenced by ergosterol or sphingolipid synthesis in fungus , . We after that analyzed the effect over the association of Rta2p with DRMs in following treatment of inhibitors (Amount 3 C and D). After contact with fluconazole for 16 hours, the number of Pma1p and Gas1p homologue connected with DRMs was notably decreased as well as the association of Rta2p with DRMs was also obstructed (Amount 3C). Following treatment of myriocin, very similar results had been attained for Pma1p, Gas1p homologue and Rta2p (Amount 3D). These outcomes biochemically confirmed that Rta2p, as well as well-known DRM-associated proteins (Pma1p and Gas1p homologue), was mostly localized in DRMs and their association had been obstructed by either fluconazole or myriocin. The disruption of obstructed the association of Pma1p and Gas1p homologue with DRMs The localization of Rta2p in lipid rafts prompted us to research whether its essential assignments in developing fluconazole level of resistance had been in fact mediated by its regulatory results in the forming of lipid rafts. First, we analyzed the consequences of Rta2p on the formation of ergosterol in acquired no.", "domain": "chemistry", "round": 3} +{"url": "http://ppc.nwsuaf.edu.cn/kycg2/397741.htm", "date": "2019-01-24T05:41:06Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-04/segments/1547584518983.95/warc/CC-MAIN-20190124035411-20190124061411-00367.warc.gz", "language_score": 0.9008429646492004, "token_count": 395, "dump": "CC-MAIN-2019-04", "global_id": "webtext-fineweb__CC-MAIN-2019-04__0__34663455", "lang": "en", "text": "我的位置: 首页> 科研成果\n论文信息：Xiaohua He, Fuzhen Guo, Bin Liu. Oolong tea and LR-White resin: a new method of plant samplepreparation for transmission electron microscopy. Journal of Microscopy, Vol. 00, Issue 0 2018, pp. 1–8. doi: 10.1111/jmi.12678\n论文摘要：Simplifying sample processing, shortening the sample preparation time, and adjusting procedures to suitable for new health and safety regulations, these issues are the current challenges which electron microscopic examinations need to face. In order to resolve these problems, new plant tissue sample processing protocols for transmission electron microscopy should be developed. In the present study, we chose the LR-White resin-assisted processing protocol for the ultrastructural observation of different types of plant tissues. Moreover, we explored Oolong tea extract (OTE) as a substitute for UA in staining ultrathin sections of plant samples. The results revealed that there was no significant difference between the OTE double staining method and the traditional double staining method. Furthermore, in some organelles, such as mitochondria in root cells of tomatoes and chloroplast in leaf cells of watermelons, the OTE double staining method achieved little better results than the traditional double staining method. Therefore, OTE demonstrated good potentials in replacing UA as a counterstain on ultrathin sections. In addition, sample preparation time was significantly shortened and simplified using LR-White resin. This novel protocol reduced the time for preparing plant samples, and hazardous reagents in traditional method (acetone and UA) were also replaced by less toxic ones (ethanol and OTE).", "domain": "chemistry", "round": 3} +{"url": "http://www.abcam.cn/recombinant-human-cd153-protein-ab119813.html", "date": "2017-06-23T10:26:20Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-26/segments/1498128320049.84/warc/CC-MAIN-20170623100455-20170623120455-00531.warc.gz", "language_score": 0.6768373847007751, "token_count": 532, "dump": "CC-MAIN-2017-26", "global_id": "webtext-fineweb__CC-MAIN-2017-26__0__197531138", "lang": "en", "text": "- 来源CHO cells\n- 序列HHHHHHHHPS PGGSGGQRTD SIPNSPDNVP LKGGNCSEDL LCILKRAPFK KSWAYLQVAK HLNKTKLSWN KDGILHGVRY QDGNLVIQFP GLYFIICQLQ FLVQCPNNSV DLKLELLINK HIKKQALVTV CESGMQTKHV YQNLSQFLLD YLQVNTTISV NVDTFQYIDT STFPLENVLS IFLYSNSD\n- 氨基酸63 to 234\n- 标签His tag N-Terminus\nOur Abpromise guarantee covers the use of\nin the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\n- 生物活性Determined by its ability to stimulate Human IL8 production by Human PBMC using a concentration range of 10.0-25.0 ng/ml. Note: Results may vary with PBMC donors.\n- 内毒素水平< 0.100 Eu/µg\n- 纯度> 95\nGreater than 95% by SDS-PAGE gel and HPLC analyses.\nDetermined by its ability to stimulate Human IL8 production by Human PBMC using a concentration range of 10.0-25.0 ng/ml. Note: Results may vary with PBMC donors.\nConcentration information loading...\nShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.\n- CD153 antigen\n- CD30 antigen ligand\n- 功能Cytokine that binds to TNFRSF8/CD30. Induces proliferation of T-cells.\n- 序列相似性Belongs to the tumor necrosis factor family.\nInformation by UniProt\nRecombinant Human CD153 protein (ab119813)参考文献\nhas not yet been referenced specifically in any publications.\nPlease note: All products are \"FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE\"", "domain": "chemistry", "round": 3} +{"url": "http://www.antibodies-online.com/tlr-signaling-pathway-21/unc93b1-elisa-kit-22342/", "date": "2017-12-14T19:11:21Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-51/segments/1512948550199.46/warc/CC-MAIN-20171214183234-20171214203234-00557.warc.gz", "language_score": 0.8853912353515625, "token_count": 1262, "dump": "CC-MAIN-2017-51", "global_id": "webtext-fineweb__CC-MAIN-2017-51__0__74381311", "lang": "en", "text": "Use your antibodies-online credentials, if available.\nNo Products on your Comparison List.\nYour basket is empty.\nFind out more\nShow all synonyms\nEndosomal localization of endogenous TLR3 (show TLR3 ELISA Kits) was decreased by silencing of LRRC59, suggesting that LRRC59 promotes UNC93B1-mediated translocation of NA-sensing TLRs from the ER upon infection.\nthe UNC93B1 tyrosine-based motif regulates trafficking and TLR responses via separate mechanisms.\nIgM(+)IgD(+)CD27 (show CD27 ELISA Kits)(+) but not switched B cells were strongly reduced in MYD88 (show MYD88 ELISA Kits)-, IRAK-4 (show IRAK4 ELISA Kits)-, and TIRAP (show TIRAP ELISA Kits)-deficient patients, but not UNC-93B-deficient patients.\nTLR3 (show TLR3 ELISA Kits) is the important regulator of UNC93B1 that in turn governs the responsiveness of all TLR3 (show TLR3 ELISA Kits) as the important regulator of UNC93B1 that in turn governs the responsiveness of all NAS (show SCN9A ELISA Kits) Toll (show TLR4 ELISA Kits)-like receptors\nUNC93B1 expression is required for TLR3 (show TLR3 ELISA Kits) cleavage and signaling.\nUNC93B1 physically associates with human TLR8 (show TLR8 ELISA Kits) and regulates TLR8 (show TLR8 ELISA Kits)-mediated signaling\nfindings elucidate a genetic etiology for herpes simplex virus encephalitis in two children with autosomal recessive deficiency in the intracellular protein (show CKAP2 ELISA Kits) UNC-93B, resulting in impaired cellular interferon-alpha (show IFNA ELISA Kits)/beta and -lambda antiviral responses\nNo UNC-93B1 mutations were foundin patients with MRS.\nIRAK-4 (show IRAK4 ELISA Kits)-, MyD88 (show MYD88 ELISA Kits)-, and UNC-93B-deficient patients did not display autoreactive antibodies in their serum or develop autoimmune diseases, suggesting that IRAK-4 (show IRAK4 ELISA Kits), MyD88 (show MYD88 ELISA Kits), and UNC-93B pathway blockade may thwart autoimmunity in humans.\nregulates ligand-induced trafficking of TLR7 (show TLR7 ELISA Kits) and TLR9 (show TLR9 ELISA Kits) from the ER to endolysosomes, potential therapeutic target for controlling dysregulated TLR7 (show TLR7 ELISA Kits)/9 responses in autoimmune diseases\nAutophagy contributes to macrophage resistance to Leishmania major. Data, including data from studies in knockout mice, suggest a key resistance mechanism involves endosomal signaling via Tlr3 (show TLR3 ELISA Kits)/7/9 in macrophages; macrophages deficient for Tlr3 (show TLR3 ELISA Kits)/7/9, Unc93b1, or MyD88 (show MYD88 ELISA Kits) fail to undergo L. major-induced autophagy. (TLR = Toll (show TLR4 ELISA Kits)-like receptor; Unc93b1 = unc-93 homolog B1; MyD88 (show MYD88 ELISA Kits) = myeloid differentiation primary response gene 88 (show MYD88 ELISA Kits))\nDescribe a mechanism for differential sorting of endosomal toll (show TLR4 ELISA Kits) like receptors by UNC93B1.\nThese observations establish a significant role for Unc93b1 in the regulation of the host inflammatory response to CVB3 infection and also reveal potential mediators of host tissue damage that merit further investigation in acute viral myocarditis.\nUnc93b1 controls activation of both myeloid and lymphoid cells during the innate immune response to influenza.\nWe discovered that TLR5 (show TLR5 ELISA Kits), a cell surface receptor for bacterial protein flagellin (show FliC ELISA Kits), also requires UNC93B1 for plasma membrane localization and signaling.\nThe observations demonstrate for the first time that activation of interferon (show IFNA ELISA Kits) and estrogen signaling in immune cells up-regulates the expression of murine Unc93b1.\nMutation of the acidic residues in TLR3 (show TLR3 ELISA Kits) and TLR9 (show TLR9 ELISA Kits) prevents UNC93B1 binding, and impairs TLR trafficking and renders the mutant receptors incapable of transmitting signals; therefore, the acidic residues in the juxtamembrane region of the nucleotide-sensing TLRs have important functional roles\nData indicate that UNC93B1 mutant and triple TLR3 (show TLR3 ELISA Kits)/7/9 knock-out mice are highly susceptible to infection with Leishmania major.\nUNC93B1 mediates innate inflammation and antiviral defense in the liver during acute murine cytomegalovirus infection.\nUNC93B, but not Toll (show TLR4 ELISA Kits)-like receptors 3, 7, and 9, is required for bacterial RNA-induced IL-1beta (show IL1B ELISA Kits) production and activation of caspase-1 (show CASP1 ELISA Kits).\nThis gene encodes a protein with similarity to the C. elegans unc93 protein. The Unc93 protein is involved in the regulation or coordination of muscle contraction in the worm.\nunc-93 homolog B1 (C. elegans)\n, protein unc-93 homolog B1\n, unc-93 related protein\n, unc93 homolog B\n, unc93 homolog B1\n, unc-93 homolog B", "domain": "chemistry", "round": 3} +{"url": "https://www.thermofisher.com/antibody/product/PTPRD-Antibody-Polyclonal/PA5-26593", "date": "2017-04-27T19:05:22Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-17/segments/1492917122619.71/warc/CC-MAIN-20170423031202-00518-ip-10-145-167-34.ec2.internal.warc.gz", "language_score": 0.8437063097953796, "token_count": 345, "dump": "CC-MAIN-2017-17", "global_id": "webtext-fineweb__CC-MAIN-2017-17__0__174230411", "lang": "en", "text": "|Tested species reactivity||Human|\n|Host / Isotype||Rabbit / IgG|\n|Immunogen||KLH conjugated synthetic peptide between 343-371 amino acids from the N-terminal region of human PTPRD|\n|Purification||Antigen affinity chromatography|\n|Contains||0.09% sodium azide|\n|Storage Conditions||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C|\n|Tested Applications||Dilution *|\n|Western Blot (WB)||1:1000|\n* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.\nPTPRD is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of three Ig-like and eight fibronectin type III-like domains. Studies of the similar genes in chicken and fly suggest the role of this PTP is in promoting neurite growth, and regulating neurons axon guidance.\nFor Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.", "domain": "chemistry", "round": 3} +{"url": "https://www.fcpeuro.com/products/high-performance-thread-sealant-50ml-56521", "date": "2017-03-01T20:24:09Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-09/segments/1487501174276.22/warc/CC-MAIN-20170219104614-00642-ip-10-171-10-108.ec2.internal.warc.gz", "language_score": 0.8457617163658142, "token_count": 251, "dump": "CC-MAIN-2017-09", "global_id": "webtext-fineweb__CC-MAIN-2017-09__0__68486015", "lang": "en", "text": "For high pressure and temperature environments\nOEM specified. Formulated specifically for metal, tapered pipe thread fittings, it replaces Teflon® tape and pipe dopes. Cures rapidly to withstand up to 10,000 PSI. Prevents galling and protects mated threaded areas from rust and corrosion. Contains PTFE. Permatex® Thread Sealants seal and secure metal pipes and fittings. By filling the space between threaded metal parts, Thread Sealants cure to a pliable seal to prevent leakage caused by vibration loosening, tape shredding, solvent evaporation, damaged threads, and temperature cycling. Designed for low and high pressure applications, Thread Sealants seal instantly for on-line low pressure testing. When fully cured, they seal to the burst strength of most piping systems. The high lubricating properties of Permatex® Thread Sealants ease assembly and prevent galling of the threads. For system repairs, parts may be disassembled with basic hand tools.\nPermatex High Performance Thread Sealant (50mL) - Permatex 56521\n- SKU #:\n- FCP ID:\n- Shop With Confidence We respect your privacy; we always keep your information confidential.", "domain": "chemistry", "round": 3} +{"url": "http://vivo.med.cornell.edu/display/pubid23744489145", "date": "2020-04-08T22:45:52Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-16/segments/1585371824409.86/warc/CC-MAIN-20200408202012-20200408232512-00037.warc.gz", "language_score": 0.8267166614532471, "token_count": 292, "dump": "CC-MAIN-2020-16", "global_id": "webtext-fineweb__CC-MAIN-2020-16__0__67962032", "lang": "en", "text": "Calcium-sensing soluble adenylyl cyclase mediates TNF signal transduction in human neutrophils\nTumor Necrosis Factor-alpha\nThrough chemical screening, we identified a pyrazolone that reversibly blocked the activation of phagocyte oxidase (phox) in human neutrophils in response to tumor necrosis factor (TNF) or formylated peptide. The pyrazolone spared activation of phox by phorbol ester or bacteria, bacterial killing, TNF-induced granule exocytosis and phox assembly, and endothelial transmigration. We traced the pyrazolone's mechanism of action to inhibition of TNF-induced intracellular Ca2+ elevations, and identified a nontransmembrane (\"soluble\") adenylyl cyclase (sAC) in neutrophils as a Ca2+-sensing source of cAMP. A sAC inhibitor mimicked the pyrazolone's effect on phox. Both compounds blocked TNF-induced activation of Rap1A, a phox-associated guanosine triphosphatase that is regulated by cAMP. Thus, TNF turns on phox through a Ca2+-triggered, sAC-dependent process that may involve activation of Rap1A. This pathway may offer opportunities to suppress oxidative damage during inflammation without blocking antimicrobial function.", "domain": "chemistry", "round": 3} +{"url": "http://fiuc.net/water/water-faqs/", "date": "2023-12-06T15:06:44Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100599.20/warc/CC-MAIN-20231206130723-20231206160723-00362.warc.gz", "language_score": 0.9517176151275635, "token_count": 267, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__223202423", "lang": "en", "text": "Water Frequently Asked Questions\n- Fire Hydrant Flushing Questions\n- Why is my water pressure low ?\nYour water pressure may be low due to the flushing of fire hydrants, which lowers the water pressure in the area that is being tested. This issue will be rectified once flushing is completed.\n- Why is my water discolored ?\nWater discoloration or turbid water is caused by the stirring of sedimentation in the water main when hydrants are flushed.\n- What should I do about the discolored water ?\nRun all faucets within your home for approximately 15 minutes or until water clears.\n- If water is discolored, is it safe for consumption ?\nThe discoloration when hydrants are flushed is caused by harmless mineral deposits which settle in the water main and are stirred during the flushing activity. The water is harmless due to the amount of chlorine that is flushed through the lines.\n- Is it OK to wash laundry when water is discolored ?\nNo. Please run all water inside the home for approximately 15 minutes or until water clears. You should check water clarity by capturing a sample from the washing machine in a clear glass or container. If water is cloudy or discolored, please do not wash laundry.", "domain": "chemistry", "round": 3} +{"url": "https://min-met.com/blog/renewable-energy-to-be-tested-for-alumina-refining/", "date": "2023-01-30T01:00:44Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-06/segments/1674764499790.41/warc/CC-MAIN-20230130003215-20230130033215-00198.warc.gz", "language_score": 0.9182985424995422, "token_count": 260, "dump": "CC-MAIN-2023-06", "global_id": "webtext-fineweb__CC-MAIN-2023-06__0__148097207", "lang": "en", "text": "The Australian Renewable Energy Agency is awarding Alcoa of Australia AUD 11.3 million toward testing the potential use of renewable energy in a Mechanical Vapor Recompression process for alumina refining. Total project cost is AUD 28.2 million. The development project has the potential to reduce carbon emissions in the alumina refining process significantly.\nAlcoa of Australia is currently conducting technical and commercial studies to adapt MVR technology to refining. Electricity sourced from renewable energy would power compressors to turn waste vapor into steam, which would then be used to provide refinery process heat.\nElectrifying steam production in the evaporation aspects of the alumina refining process could displace fossil fuel boiler steam production in the process. Demonstrating successful operation of the technology for evaporation could enable its use to be extended to other process duties, further displacing fossil fuels.\nIf the feasibility studies are successful, Alcoa of Australia plans to install, by the end of 2023, a three megawatt MVR module with renewable energy at the Wagerup refinery in Western Australia to test the technology at scale.\nIn 2019, Australian alumina refining accounted for more than 14 million tonnes of carbon dioxide emissions, representing approximately 24% of Australia’s scope 1 manufacturing emissions.", "domain": "chemistry", "round": 3} +{"url": "https://www.fishersci.co.uk/shop/products/r-d-systems-viral-cmv-ul146-vcxc1-recombinant-protein-1/13445724", "date": "2020-01-22T19:56:55Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-05/segments/1579250607407.48/warc/CC-MAIN-20200122191620-20200122220620-00157.warc.gz", "language_score": 0.7663248777389526, "token_count": 250, "dump": "CC-MAIN-2020-05", "global_id": "webtext-fineweb__CC-MAIN-2020-05__0__15545524", "lang": "en", "text": "R&D Systems™ Viral CMV UL146/vCXC1 Recombinant Protein\nExtensive quality control produces industry leading bioactivity and lot-to-lot consistency that instills confidence in results and ensures reproducibility.\nBrand: R&D Systems™ 620-CM-025/CF\nCode : Z1\nAdditional Details : Weight : 0.00010kg\nDescriptionThe Recombinant Viral CMV UL146/vCXC1 Protein is derived from E. coli. The Recombinant Viral CMV UL146/vCXC1 Protein has been validated for the following applications: Bioactivity.\n|Lyophilized from a 0.2μm filtered solution in Acetonitrile and TFA.|\n|Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70° C as supplied. 1 month, 2 to 8° C under sterile conditions after reconstitution. 3 months, -20 to -70° C under sterile conditions after reconstitution.|\n|97%, by SDS-PAGE under reducing conditions and visualized by silver stain.|", "domain": "chemistry", "round": 3} +{"url": "https://pubmed.ncbi.nlm.nih.gov/19457116/?dopt=Abstract", "date": "2021-04-14T23:41:08Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-17/segments/1618038078900.34/warc/CC-MAIN-20210414215842-20210415005842-00372.warc.gz", "language_score": 0.91710364818573, "token_count": 400, "dump": "CC-MAIN-2021-17", "global_id": "webtext-fineweb__CC-MAIN-2021-17__0__222856461", "lang": "en", "text": "Synaptic transmission depends on the efficient loading of transmitters into synaptic vesicles by vesicular neurotransmitter transporters. The vesicular monoamine transporter-2 (VMAT2) is essential for loading monoamines into vesicles and maintaining normal neurotransmission. In an effort to understand the regulatory mechanisms associated with VMAT2, we have embarked upon a systematic search for interacting proteins. Glutathione-S-transferase pull-down assays combined with mass spectrometry led to the identification of the 70-kDa heat shock cognate protein (Hsc70) as a VMAT2 interacting protein. Co-immunoprecipitation experiments in brain tissue and heterologous cells confirmed this interaction. A direct binding was observed between the amino terminus and the third cytoplasmic loop of VMAT2, as well as, a region containing the substrate binding and the carboxy-terminal domains of Hsc70. Furthermore, VMAT2 and Hsc70 co-fractionated with purified synaptic vesicles obtained from a sucrose gradient, suggesting that this interaction occurs at the synaptic vesicle membrane. The functional significance of this novel VMAT2/Hsc70 interaction was examined by performing vesicular uptake assays in heterologous cells and purified synaptic vesicles from brain tissue. Recombinant Hsc70 produced a dose-dependent inhibition of VMAT2 activity. This effect was mimicked by the closely related Hsp70 protein. In contrast, VMAT2 activity was not altered in the presence of previously denatured Hsc70 or Hsp70, as well as the unrelated Hsp60 protein; confirming the specificity of the Hsc70 effect. Finally, a purified Hsc70 fragment that binds VMAT2 was sufficient to inhibit VMAT2 activity in synaptic vesicles. Our results suggest an important role for Hsc70 in VMAT2 function and regulation.", "domain": "chemistry", "round": 3} +{"url": "https://39clues.fandom.com/wiki/Copper", "date": "2022-08-18T22:04:28Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882573533.87/warc/CC-MAIN-20220818215509-20220819005509-00757.warc.gz", "language_score": 0.7918587923049927, "token_count": 398, "dump": "CC-MAIN-2022-33", "global_id": "webtext-fineweb__CC-MAIN-2022-33__0__106139405", "lang": "en", "text": "This article is about a real-world person, place, or thing. For more information, see the corresponding Wikipedia page here.\nAmy and Dan's mother, Hope Cahill, never took an X-Ray exam. Nobody knew why, but the shocking truth was revealed when she was hurt in a car accident: a special computer chip in her wrist contained data about a Clue.\nThe scene first shows an X-ray of Hope's arm. It zooms in on the microchip. The X-ray decodes it, and after that, the X-ray disappears with stripes of blue light, and the word COPPER appears.\nCopper is chemical element with the symbol Cu and atomic number 29. It's used in wiring, building materials, and other various uses. Copper has been used longer than any other common metal, which may be why it's a Clue. It is used as plating on pennies.\n|v • d • e Clues|\n|Lucian Clues||Amber • Blood • Calcium Carbonate • Clover • Iron Solute • Mint • Salt|\n|Janus Clues||Cobra Venom • Honey • Iodine • Pearl • Platinum • Silk • Sulfur • Tungsten|\n|Tomas Clues||Aloe • Bone • Cocoa • Gold • Lead • Magnesium • Quartz • Wormwood • Zinc|\n|Ekaterina Clues||Hydrogen • Mercury • Myrrh • Phosphorus • Silver • Uranium • Water|\n|Madrigal Clues||Barley • Copper • Lily • Mace • Pepper • Rosemary • Vinegar • Serum Formula|\n|False Clues||Thyme • Diamond • Tin|\n|Serums||Master Serum • Lucian • Janus • Tomas • Ekaterina • Madrigal|", "domain": "chemistry", "round": 3} +{"url": "https://rup.silverchair.com/jem/article/165/6/1719/23929/Human-autoantibodies-against-a-desmosomal-protein", "date": "2022-12-10T03:17:38Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-49/segments/1669446711637.64/warc/CC-MAIN-20221210005738-20221210035738-00484.warc.gz", "language_score": 0.8354265689849854, "token_count": 330, "dump": "CC-MAIN-2022-49", "global_id": "webtext-fineweb__CC-MAIN-2022-49__0__180381719", "lang": "en", "text": "Pemphigus foliaceus (PF) patients have antibodies against a tightly, but noncovalently bound complex of polypeptides, which consists of desmoglein I (DGI) and other, possibly desmosomal, proteins. Most PF antibodies bind a calcium-sensitive epitope on this complex and chelation of calcium destroys the reactivity of these sera with the complex, but not the complex itself. The PF sera that do bind the desmosomal complex in the absence of calcium are those sera capable of binding denatured DGI on immunoblotting, and these same sera also immunoprecipitate only DGI when the desmosomal complex is dissociated with SDS. These findings demonstrate that autoantibodies against a complex of desmosome-associated proteins are characteristic of PF and define a calcium-sensitive conformational epitope on this complex.\nHuman autoantibodies against a desmosomal protein complex with a calcium-sensitive epitope are characteristic of pemphigus foliaceus patients.\n- Views Icon Views\n- Share Icon Share\n- Search Site\nR W Eyre, J R Stanley; Human autoantibodies against a desmosomal protein complex with a calcium-sensitive epitope are characteristic of pemphigus foliaceus patients.. J Exp Med 1 June 1987; 165 (6): 1719–1724. doi: https://doi.org/10.1084/jem.165.6.1719\nDownload citation file:", "domain": "chemistry", "round": 3} +{"url": "https://en.wikipedia.org/wiki/Transferrin_saturation", "date": "2016-12-03T17:09:00Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2016-50/segments/1480698540975.18/warc/CC-MAIN-20161202170900-00237-ip-10-31-129-80.ec2.internal.warc.gz", "language_score": 0.9062017202377319, "token_count": 275, "dump": "CC-MAIN-2016-50", "global_id": "webtext-fineweb__CC-MAIN-2016-50__0__29683741", "lang": "en", "text": "|This article does not cite any sources. (December 2009) (Learn how and when to remove this template message)|\nTransferrin saturation, abbreviated as TSAT and measured as a percentage, is a medical laboratory value. It is the ratio of serum iron and total iron-binding capacity. Of the transferrin that is available to bind iron, this value tells a clinician how much serum iron are actually bound. For instance, a value of 15% means that 15% of iron-binding sites of transferrin are being occupied by iron. For an explanation of some clinical situations in which this ratio is important, see Total iron-binding capacity. The three results are usually reported together.\nNormal reference ranges are:\n- Serum iron: 60–170 μg/dl (10–30μmol/L)\n- TIBC: 240–450 μg/dl\n- Transferrin saturation: 15–50% (males), 12–45% (females)\nμg/dl = micrograms per deciliter.\nLaboratories often use different units and \"normal\" may vary by population and the lab techniques used. Look at the individual laboratory reference values to interpret a specific test (for instance, your own).\n|This article related to pathology is a stub. You can help Wikipedia by expanding it.|", "domain": "chemistry", "round": 3} +{"url": "https://www.e3s-conferences.org/articles/e3sconf/abs/2017/10/e3sconf_asee2017_00133/e3sconf_asee2017_00133.html", "date": "2022-08-08T01:58:38Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882570741.21/warc/CC-MAIN-20220808001418-20220808031418-00083.warc.gz", "language_score": 0.8621742725372314, "token_count": 566, "dump": "CC-MAIN-2022-33", "global_id": "webtext-fineweb__CC-MAIN-2022-33__0__183452337", "lang": "en", "text": "E3S Web Conf.\nVolume 22, 2017International Conference on Advances in Energy Systems and Environmental Engineering (ASEE17)\n|Number of page(s)||8|\n|Published online||07 November 2017|\nChemical treatment of wastewater from flue gas desulphurisation\nWroclaw University of Science and Technology, Faculty of Environmental Engineering, Wybrzeze Wyspianskiego 27, 30-370 Wroclaw, Poland\n* Corresponding author: email@example.com\nThe article presents results of laboratory tests of removing boron and arsenium from non-ideal solutions using double-layered magnesium/aluminium hydroxides (Mg/Al Double-Layered Hydroxide – DLH) produced with nitrate-chloride method. In research, wastewater from an installation for flue gas desulfurization was examined. Double-layered hydroxides are perfect absorbents for anionic compounds. The research proved high effectiveness of preparation with reference to arsenium, as well as confirmed the effect of presence of sulfatic and arsenate ions on the effectiveness of boron removal. On the basis of research on absorption kinetics a theoretical dose of DLH/NO3-Cl/M preparation was calculated and compared with a dose that ensures emimination of boron below the limit standarized by the national regulations. Application of double-layered magnesium/aluminium hydroxides for boron elimination from industrial wastewater requires significantly higher doses of preparation than those calculated in model investigations. It is due to the priority of removal of multivalent ions, such as sulfatic, arsenate or phosphate ions, by DLH/NO3-Cl/M.\n© The Authors, published by EDP Sciences, 2017\nThis is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (http://creativecommons.org/licenses/by/4.0/).\nCurrent usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.\nData correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.\nInitial download of the metrics may take a while.", "domain": "chemistry", "round": 3} +{"url": "http://www.cellapplications.com/product-type/anti-polyarginine-rabbit-poly-arginine-9r-antibody?id=1827", "date": "2015-09-05T14:12:56Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2015-35/segments/1440646312602.99/warc/CC-MAIN-20150827033152-00043-ip-10-171-96-226.ec2.internal.warc.gz", "language_score": 0.8978794813156128, "token_count": 776, "dump": "CC-MAIN-2015-35", "global_id": "webtext-fineweb__CC-MAIN-2015-35__0__91674287", "lang": "en", "text": "Top: Western Blot detection of 11R-tagged reprogramming factors, including human c-Myc, KLF4, Oct4, and Sox2 proteins, using Polyarginine (9R) Antibody (Cat# CY1114). Middle: This antibody also stains Human Dermal Fibroblasts (HDF)^ (Cat# 106-05a) transduced with the 11R-tagged reprogramming factors, human c-Myc, KLF4, Oct4, and Sox2 proteins (Right), but not untreated HDF (left), in immunofluorescent analysis. (^This cell was also used by Dr. Yamanaka\\'s lab to generate the world\\'s first iPS cells. See: Takahashi, K. et al: Cell 131:861-72, 2007.)\nCPPs have proven to be very efficient in delivering molecules into cells that are refractory to transfection such as primary lymphocytes. Their penetration into cells is rapid and initially first-order, with half-times from 5 to 20 min. Recently, Dr. Sheng Ding’s lab designed and fused a poly-arginine (i.e., 11R) protein transduction domain to the C terminus of four reprogramming factors: Oct4, Sox2, Klf4, and c-Myc, and recombinant fusion proteins were made in E. coli. It was shown that the purified 11R-tagged recombinant transcription factors readily entered MEF cells which can be fully reprogrammed into pluripotent stem cells (iPSs) by direct delivery of recombinant reprogramming proteins.3 It is well known that the potential of iPS cells is enormous. However, the clinical application of iPS cells faces many obstacles. One of the challenges is that since the cells are artificially created to have pluripotency by inducing genes, they are inclined to form tumors. Dr. Ding’s nongenetic approach eliminates any risk of modifying the target cell genome by exogenous genetic sequences, which are associated with all previous iPSC methods. Thus, polyarginine-tagged protein transduction method provides a more efficient way of producing safer iPS cells without tendency to form tumors. In addition to acting as novel vehicle for the translocation of cargo into cells, polyarginie peptide has been used in various other biological applications. It was reported that oligoarginine chain was coupled with oligodeoxynucleotide probe to produce peptide-oligonucleotide conjugates or peptide-bridged oligonucleotide pairs. These probe-peptide conjugates induce the oligodeoxynucleotides to bind complementary single-stranded DNA or RNA targets with substantially enhanced thermal stability, which will be useful in the development of antisense strategies.4\n2. Sawant, R. & Torchilin, V.: Mol. BioSyst., 6:628-640, 2010\n3. Zhou, H. et al: Cell Stem Cell 4:381-4, 2009\n4. Wei, Z. et al: Nucl. Acids Res. 24:655-61, 1996\nShort 9-mer arginine peptide coupled with KLH.\nSpecies & predicted\nreactivity ( ):\nICC 1:50 - 1:200\nWeight of protein:\n1 kDa + Target Protein\nDetects 9R-tagged proteins without cross-reactivity with un-tagged proteins.\nStore at -20°C, 4°C for frequent use. Avoid repeated freeze-thaw cycles.\n*Optimal working dilutions must be determined by end user.", "domain": "chemistry", "round": 3} +{"url": "https://www.seasonedessaywriters.com/toxicology-processes-and-procedures/", "date": "2023-06-02T22:14:49Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-23/segments/1685224648858.14/warc/CC-MAIN-20230602204755-20230602234755-00697.warc.gz", "language_score": 0.9378042817115784, "token_count": 291, "dump": "CC-MAIN-2023-23", "global_id": "webtext-fineweb__CC-MAIN-2023-23__0__230399643", "lang": "en", "text": "Posted: May 22nd, 2023\nWith the explanation of the effects of nano-particles, difference experts and professionals have used different approaches to express their ideas on the way nano-particles affect the bios. For instances, nano-particle manufacturing engineers express their ideas of toxicology by showing that such minute particulate materials have the potential of producing free radicals with high reactivity due to their large surface area compared to volume ratios. The produced radicals potentially cause numerous problems in the body of organisms by creating an oxidative stress environment. Additionally, there are some Bio-engineers who hold that these oxidative stresses are detrimental, and they bring about genotoxicity, which further leads to inflammatory diseases or conditions. The oxidative stress and genotoxicity are both major processes which cause adverse body effects leading to malfunctioning of foremost body systems, or organs including the brain, cardiovascular and respiratory systems. Even though many cosmetic therapists and food experts together with a number of tissue engineers believe that nano-particles can be positively utilized for the benefit of human beings, they claim that nano-particles diffuses through the skin tissues, organ and cell membranes. The clustering of nano-particles and their subsequent entry into the nucleus portion affects the uptake of other important materials into the cells, and thus affecting the overall functionality of the entire cell (Kong, 2007, 2079).\nPlace an order in 3 easy steps. Takes less than 5 mins.", "domain": "chemistry", "round": 3} +{"url": "https://www.bulkreefsupply.com/content/post/a-challenge-three-effective-filters-for-organic-dissolved-and-inorganic-nutrients-in-reef-aquariums", "date": "2023-05-29T05:27:13Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-23/segments/1685224644683.18/warc/CC-MAIN-20230529042138-20230529072138-00611.warc.gz", "language_score": 0.7369174957275391, "token_count": 297, "dump": "CC-MAIN-2023-23", "global_id": "webtext-fineweb__CC-MAIN-2023-23__0__79095201", "lang": "en", "text": "A Challenge: Three Effective Filters for Organic, Dissolved & Inorganic Nutrients in Reef Aquariums\nLast updated: Apr 18, 2022\nReef tank filtration... How do filter socks and fleece rollers control Nitrates and Phosphates? How do protein skimmers remove nitrate and phosphate? What about refugiums, algae reactors, and scrubbers?\nThere are three stages to filtration: Stage 1- Solid form waste removal. Stage 2- Broken down dissolved waste removal. Stage 3- Testable Nitrate & Phosphate removal. Find out what it takes to achieve all three and successfully export nutrients from your aquarium.\nHanna InstrumentsPhosphate Ultra Low Range PPM Colorimeter HI774 Hanna Checker - Marine Water\nHanna InstrumentsHI764-25 Nitrite ULR Reagents for HI764 Checker - Marine Water\nHanna InstrumentsNitrite Ultra Low Range Colorimeter HI764 Hanna Checker - Marine Water\nHanna InstrumentsHI713-11 Phosphate Calibration Check Set for HI713 Checker\nHanna InstrumentsNitrite Low Range Colorimeter HI707 Hanna Checker - Fresh Water\nLogin and Registration Form", "domain": "chemistry", "round": 3} +{"url": "https://www.mdpi.com/2504-3900/1/4/496", "date": "2018-10-17T05:20:09Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-43/segments/1539583510998.39/warc/CC-MAIN-20181017044446-20181017065946-00064.warc.gz", "language_score": 0.7589946389198303, "token_count": 395, "dump": "CC-MAIN-2018-43", "global_id": "webtext-fineweb__CC-MAIN-2018-43__0__161105192", "lang": "en", "text": "Silicon Nanowires Based Resistors for Bacteria Detection†\nAbstractSilicon nanowires (SiNWs) based resistors used as bacteria sensors are fabricated using the classical silicon technologies. SiNWs are grown by vapor liquid solid (VLS) method using gold as catalyst. Electrodes of the device are made of heavily in-situ doped polycristalline silicon. Results show potential use of the corresponding resistors, with SiNWs as sensitive units, for bacteria detection. Bacteria are preferentially hanged into SiNWs array and electrical resistance of the device decreases due to the presence of bacteria. Such resistors are promising bacteria sensors to monitor contamination in controlled environment for hygiene, fabricated in a simple and low-cost fabrication technology.\nShare & Cite This Article\nBorgne, B.L.; Salaun, A.C.; Pichon, L.; Jolivet-Gougeon, A.; Martin, S.; Rogel, R.; Sagazan, O. Silicon Nanowires Based Resistors for Bacteria Detection. Proceedings 2017, 1, 496.\nBorgne BL, Salaun AC, Pichon L, Jolivet-Gougeon A, Martin S, Rogel R, Sagazan O. Silicon Nanowires Based Resistors for Bacteria Detection. Proceedings. 2017; 1(4):496.Chicago/Turabian Style\nBorgne, Brice Le; Salaun, Anne Claire; Pichon, Laurent; Jolivet-Gougeon, Anne; Martin, Sophie; Rogel, Regis; Sagazan, Olivier de. 2017. \"Silicon Nanowires Based Resistors for Bacteria Detection.\" Proceedings 1, no. 4: 496.\nNote that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.", "domain": "chemistry", "round": 3} +{"url": "https://www.semanticscholar.org/paper/Decay-of-hormone-responsiveness-in-mouse-melanoma-Fuller-Lebowitz/4ef9b0921c4a280cd7090620a5baf196b0368065", "date": "2017-12-13T01:40:25Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-51/segments/1512948520218.49/warc/CC-MAIN-20171213011024-20171213031024-00602.warc.gz", "language_score": 0.9237018823623657, "token_count": 280, "dump": "CC-MAIN-2017-51", "global_id": "webtext-fineweb__CC-MAIN-2017-51__0__35589372", "lang": "en", "text": "Cloudman S91 mouse melanoma cells lose their ability to demonstrate an MSH-induced increase in tyrosinase activity as cell density increases. This loss in hormone responsiveness occurs before confluency is reached and cannot be reversed by exposure of cells to increasing concentrations of MSH. The failure of high-density cultures to respond to MSH is apparently not the result of an inability of MSH to stimulate cAMP production, since either low- or high-density cultures exposed to MSH demonstrate equivalent increases in intracellular levels of cAMP. Further, neither theophylline (1mM), dibutyryl cyclic AMP (10(-4)M), or prostaglandin E1 (10(-6)M) is effective in stimulating tyrosinase activity in melanoma cells cultured at densities exceeding 6 X 10(4) cells/cm2. This finding suggests that the decay of hormone responsiveness occurs at a cellular site distal to cAMP production. The decrease in tyrosinase stimulation by MSH as cell density increases is also apparently not the result of an increase in activity of any soluble inhibitor of the enzyme, for cytosol preparations from high-density cultures (10(5) cells/cm2) fail to inhibit tyrosinase activity in cell homogenates from low-density cultures treated with MSH.", "domain": "chemistry", "round": 3} +{"url": "http://www.circular.industries/critical-raw-materials.html", "date": "2019-11-15T06:21:50Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-47/segments/1573496668585.12/warc/CC-MAIN-20191115042541-20191115070541-00164.warc.gz", "language_score": 0.838290274143219, "token_count": 358, "dump": "CC-MAIN-2019-47", "global_id": "webtext-fineweb__CC-MAIN-2019-47__0__32418599", "lang": "en", "text": "Critical Raw Materials\nThe increasing global demand for Critical Raw Materials (CRMs) results in a decreasing availability. Only by maximizing the recovery of CRMs from waste streams, we can preserve these materials for our future generations.\n10+ Critical Raw Materials\nThe Urban Mining Factory - Critical Raw Materials (UMF-CRM) will become the world’s first factory that focuses on maximum recovery of CRMs from waste streams. No other factory will produce a greater variety of CRMs than the UMF-CRM.\nApplications of CRMs\nCRMs are being used many important and high-tech applications, among others: medicine, hospital equipment, consumer electronics, electric vehicles, wind mills, satellites, etc.\nDependence on suppliers\nChina is the major supplier of Critical Raw Materials, accounting for 70% of the global supply and 62% of the supply to the EU (e.g. neodymium, magnesium, antimony, natural graphite, etc.). When it comes to the Rare Earths elements, China produces 96% of these elements. For example a Rare Earth metal like Neodymium, 30% stronger than other magnetic elements, is of great importance for maximum power generation in wind mills.\nThe countries that produce CRMs have now started catching up in the field of sustainable energy and sustainable industry. The risks for the European Union associated with the dependency of non-European suppliers, become even greater due to low substitution and low recycling percentages within the European Union.\nCircular Industries is the first European producer of CRMs to act on this subject.\nRead Niels Wagemaker’s LinkedIn post regarding Critical Raw Materials.\nKrijn Taconskade 348\n1087 HW Amsterdam\nChief Executive Officer:", "domain": "chemistry", "round": 3} +{"url": "http://www.princeton.edu/cee/people/display_pubs/?netid=jaffe", "date": "2014-12-21T12:28:31Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2014-52/segments/1418802771133.144/warc/CC-MAIN-20141217075251-00023-ip-10-231-17-201.ec2.internal.warc.gz", "language_score": 0.6765356659889221, "token_count": 417, "dump": "CC-MAIN-2014-52", "global_id": "webtext-fineweb__CC-MAIN-2014-52__0__121916843", "lang": "en", "text": "For a complete listing of publications, click here.\n- Shrestha, J., J.R. Rich, J.G. Ehrenfeld, and P.R. Jaffe. Oxidation of Ammonium to Nitrite under Iron Reducing Conditions in Wetland Soils; Laboratory, Field Demonstrations and Push Pull Rate Determination. Soil Science, Vol. 174, No. 3, 2009, pp. 156-164.\n- Moon, H.S., J. Komlos, and P.R. Jaffe. Biogenic U(IV) Oxidation by Dissolved Oxygen and Nitrate in Sediment after Prolonged U(VI)/Fe(III)/SO42- Reduction. Journal of Contaminant Hydrology, Vol. 105, 2009, pp. 18-27.\n- Kim, H.S. and P.R. Jaffe. Degradation of Toluene by a Mixed Population of Archetypal Aerobes, Microaerophiles, and Denitrifiers: Laboratory Sand Column Experiment and Multispecies Biofilm Model Formulation. Biotechnology and Bioengineering, 2008, Vol. 99, No. 2, pp. 290-301.\n- Zazo, J.A., J.S. Paull, and P.R. Jaffe. Influence of Plants on the Reduction of Hexavalent Chromium in Wetland Sediments. Environmental Pollution, March 2008, doi:10.1016/j.envpol.2008.01.006, 156, 2008, pp. 29-35.\n- Komlos, J., R. Kukkadapu, J.M. Zachara, and P.R. Jaffe. Biostimulation of Iron Reduction and Subsequent Oxidation of Sediment Containing Fe-silicates and Fe-oxides: Effect of Redox Cycling on Fe(III) Bioreduction. Water Research, Vol. 41, 2007, pp. 2996-3004.", "domain": "chemistry", "round": 3} +{"url": "https://www.thermofisher.com/antibody/product/Nav-15-Antibody-4G8-Monoclonal/MA1-27429", "date": "2017-04-27T07:39:11Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-17/segments/1492917121893.62/warc/CC-MAIN-20170423031201-00018-ip-10-145-167-34.ec2.internal.warc.gz", "language_score": 0.7367211580276489, "token_count": 343, "dump": "CC-MAIN-2017-17", "global_id": "webtext-fineweb__CC-MAIN-2017-17__0__190463415", "lang": "en", "text": "|Tested species reactivity||Human|\n|Host / Isotype||Mouse / IgM|\n|Immunogen||Synthetic peptide corresponding to a portion of the extracellular domain of Nav1.5.|\n|Storage buffer||PBS, pH 7.2|\n|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|\n|Tested Applications||Dilution *|\n|Immunocytochemistry (ICC)||10 µg/ml|\n|Immunofluorescence (IF)||10 ug/ml|\n|Western Blot (WB)||2 µg/ml|\n* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.\nMA1-27429 detects Nav 1.5 from human samples.\nMA1-27429 may be successfully used in immunocytochemistry, immunofluorescence and Western blot applications.\nThe MA1-27429 immunogen is a synthetic peptide corresponding to an extracellular domain of Nav1.5.\nVoltage-gated sodium channesl (VGSCs) mediate regenerative cell membrane depolarization and conduction of electrical signalling in nerves and muscles. Expression is also detected in lymphocytes, glia, and fibroblasts. VGSC proteins are comprised of a core\nFor Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.", "domain": "chemistry", "round": 3} +{"url": "http://nku-ky.newlook.safecollegessds.com/document/view/fb6a143f-3656-4fcd-9712-0b4357fea730/a3db35a8-d92b-462e-9cea-bd9d78ed870c/1-Butanol?location_id=9684d119-4bc7-4d0a-bbdb-952b35e94a10", "date": "2024-03-01T16:53:02Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707947475422.71/warc/CC-MAIN-20240301161412-20240301191412-00435.warc.gz", "language_score": 0.8326759934425354, "token_count": 362, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__83751306", "lang": "en", "text": "Flammable liquid and vapour. Harmful if swallowed. Causes skin irritation. Causes serious eye damage. May cause respiratory irritation. May cause drowsiness or dizziness.\nKeep away from heat/sparks/open flames/hot surfaces. No smoking. Keep container tightly closed. Ground/bond container and receiving equipment. Use explosion-proof electrical/ ventilating/ lighting/ equipment. Use only non-sparking tools. Take precautionary measures against static discharge. Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray. Wash skin thoroughly after handling. Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Wear protective gloves/ eye protection/ face protection. IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor if you feel unwell. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER/doctor. If skin irritation occurs: Get medical advice/ attention. Take off contaminated clothing and wash before reuse. In case of fire: Use dry sand, dry chemical or alcohol-resistant foam to extinguish. Store in a well-ventilated place. Keep container tightly closed. Store in a well-ventilated place. Keep cool. Store locked up. Dispose of contents/ container to an approved waste disposal plant.\nNorthern Kentucky University", "domain": "chemistry", "round": 3} +{"url": "https://selectech.co.za/product/conductivity-ec-bench-meter-xs8/", "date": "2020-11-30T20:37:55Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-50/segments/1606141486017.50/warc/CC-MAIN-20201130192020-20201130222020-00392.warc.gz", "language_score": 0.8628710508346558, "token_count": 296, "dump": "CC-MAIN-2020-50", "global_id": "webtext-fineweb__CC-MAIN-2020-50__0__164982709", "lang": "en", "text": "A popular, economical and reliable bench meter for measuring electrical conductivity (EC) in liquids with up-to-date technology.\nIncludes TDS / Salinity / Temperature / GLP / Data logger.\nElectrical Conductivity is frequently measured in water quality analysis in laboratories, production plants and educational institutions.\nIndustrial labs, process / waste water testing, chemical industry, printing, quality assurance testing, titrations, ecological studies, educational institutions\n- Measures conductivity / TDS / salinity and temperature\n- Wide, colourful display shows measurements, buffer solutions used in last calibration, cell constant, GLP and data in memory\n- Automatic or manual temperature compensation, reference values 15 … 30°C\n- Easy to use with only 5 keys\n- Automatic calibration of 1 – 4 points\n- Three different conductivity electrodes, each with a different cell constant, assures the end-user can measure accurately as per their sample’s EC value\n- It is possible to use more than one conductivity cell, each with a different cell constant, and to save the calibration per cell constant\n- Numeric password to delete data memory and to manage calibrations\n- Stability indication with icon\n- Selectable calibration timer\n- Memory can hold up to 1 000 data sets, includes date and time\n- Data can be downloaded to PC with free software or printed\n- Multi-language interface – English, Spanish, French, German, Italian and Czech", "domain": "chemistry", "round": 3} +{"url": "http://tums.ac.ir/faculties/nekoofar?paperid=38385", "date": "2017-11-22T16:34:08Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-47/segments/1510934806615.74/warc/CC-MAIN-20171122160645-20171122180645-00278.warc.gz", "language_score": 0.8672006726264954, "token_count": 562, "dump": "CC-MAIN-2017-47", "global_id": "webtext-fineweb__CC-MAIN-2017-47__0__124257059", "lang": "en", "text": "Tehran University of Medical Sciences\nMohammad Hossein Nekoofar\nThe effect of condensation pressure on selected physical properties of mineral trioxide aggregate\nAuthors: Nekoofar, M. H. - Adusei, G. - Sheykhrezae, M. S. - Hayes, S. J. - Bryant, S. T. - Dummer, P. M. -\nKeywords: Aluminum Compounds/*chemistry , Calcium Compounds/*chemistry , Compressive Strength , Crystallization , Drug Combinations , Hardness , Humans , Materials Testing , Microscopy, Electron, Scanning , Oxides/*chemistry , Polycarboxylate Cement , Porosity , Pressure , Root Canal Filling Materials/*chemistry , Silicates/*chemistry , Stress, Mechanical , Surface Properties ,\nInt Endod J, Vol.40, No.6, 2007,Page:453-61\nAIM: To examine the effect of condensation pressure on surface hardness, microstructure and compressive strength of mineral trioxide aggregate (MTA). METHODOLOGY: White ProRoot MTA (Dentsply Tulsa Dental, Johnson City, TN, USA) was mixed and packed into cylindrical polycarbonate tubes. Six groups each of 10 specimens were subjected to pressures of 0.06, 0.44, 1.68, 3.22, 4.46 and 8.88 MPa respectively. The surface hardness of each specimen was measured using Vickers microhardness. Cylindrical specimens of 4 mm in diameter and 6 mm in height were prepared in polycarbonate cylindrical moulds for testing the compressive strength. Five groups of 10 specimens were prepared using pressures of 0.06, 0.44, 1.68, 3.22 or 4.46 MPa. Data were subjected to one-way anova. The microstructure was analysed using a scanning electron microscope (SEM) after sectioning specimens with a scalpel. RESULT: A trend was observed for higher condensation pressures to produce lower surface hardness values. A condensation pressure of 8.88 MPa produced specimens with significantly lower values in terms of surface hardness than other groups (P<0.001). A condensation pressure of 1.68 MPa conferred the maximum compressive strength; however, it was not statistically different. Higher condensation pressures resulted in fewer voids and microchannels when analysed with SEM. In specimens prepared with lower condensation pressures distinctive crystalline structures were observed. They tended to appear around microchannels. CONCLUSION: Condensation pressure may affect the strength and hardness of MTA. Use of controlled condensation pressure in sample preparation for future studies is suggested.", "domain": "chemistry", "round": 3} +{"url": "https://www.iris.unict.it/handle/20.500.11769/34799", "date": "2018-10-21T14:02:50Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-43/segments/1539583514030.89/warc/CC-MAIN-20181021140037-20181021161537-00396.warc.gz", "language_score": 0.8252008557319641, "token_count": 450, "dump": "CC-MAIN-2018-43", "global_id": "webtext-fineweb__CC-MAIN-2018-43__0__229266514", "lang": "en", "text": "Porin isoform 1 or VDAC (voltage-dependent anion-selective channel) 1 is the predominant protein in the outer mitochondrial membrane. We demonstrated previously that a plasma membrane NADH-ferricyanide reductase activity becomes up-regulated upon mitochondrial perturbation, and therefore suggested that it functions as a cellular redox sensor. VDAC1 is known to be expressed in the plasma membrane; however, its function there remained a mystery. Here we show that VDAC1, when expressed in the plasma membrane, functions as a NADH-ferricyanide reductase. VDAC1 preparations purified from both plasma membrane and mitochondria fractions exhibit NADH-ferricyanide reductase activity, which can be immunoprecipitated with poly- and monoclonal antibodies directed against VDAC(1). Transfecting cells with pl-VDAC1-GFP, which carries an N-terminal signal peptide, directs VDAC1 to the plasma membrane, as shown by confocal microscopy and FACS analysis, and significantly increases the plasma membrane NADH-ferricyanide reductase activity of the transfected cells. This novel enzymatic activity of the well known VDAC1 molecule may provide an explanation for its role in the plasma membrane. Our data suggest that a major function of VDAC1 in the plasma membrane is that of a NADH(-ferricyanide) reductase that may be involved in the maintenance of cellular redox homeostasis.\n|Titolo:||VDAC1 is a transplasma membrane NADH:ferricyanide reductase|\n|Data di pubblicazione:||2004|\n|Citazione:||VDAC1 is a transplasma membrane NADH:ferricyanide reductase / M. A. BAKER; J. D. LY; DE PINTO V; A. LAWEN. - 279(2004), pp. 4811-4819.|\n|Appare nelle tipologie:||1.1 Articolo in rivista|", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/cdk1-phospho-t14-antibody-ab58509.html", "date": "2020-09-18T12:42:50Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-40/segments/1600400187899.11/warc/CC-MAIN-20200918124116-20200918154116-00303.warc.gz", "language_score": 0.8007752299308777, "token_count": 920, "dump": "CC-MAIN-2020-40", "global_id": "webtext-fineweb__CC-MAIN-2020-40__0__262795660", "lang": "en", "text": "Key features and details\n- Rabbit polyclonal to CDK1 (phospho T14)\n- Suitable for: WB, ELISA, ICC/IF\n- Reacts with: Human\n- Isotype: IgG\nProduct nameAnti-CDK1 (phospho T14) antibody\nSee all CDK1 primary antibodies\nDescriptionRabbit polyclonal to CDK1 (phospho T14)\nSpecificityDetects endogenous levels of CDC2 only when phosphorylated at threonine 14.\nTested applicationsSuitable for: WB, ELISA, ICC/IFmore details\nSpecies reactivityReacts with: Human\nPredicted to work with: Mouse, Rat\nSynthetic phosphopeptide derived from human Cdc2 around the phosphorylation site of threonine 14 (E-G-TP-Y-G).\nStorage instructionsShipped at 4°C. Upon delivery aliquot. Store at -20°C. Avoid freeze / thaw cycle. Stable for 12 months at -20°C.\nStorage bufferpH: 7.40\nPreservative: 0.02% Sodium azide\nConstituents: PBS, 50% Glycerol, 0.87% Sodium chloride\nConcentration information loading...\nPurityImmunogen affinity purified\nPurification notesAffinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.\nOur Abpromise guarantee covers the use of ab58509 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\n|WB||1/500 - 1/1000. Detects a band of approximately 32 kDa (predicted molecular weight: 34 kDa).|\n|ICC/IF||1/100 - 1/500.|\nFunctionPlays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis. p34 is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II.\nTissue specificityIsoform 2 is found in breast cancer tissues.\nSequence similaritiesBelongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.\nContains 1 protein kinase domain.\n- Information by UniProt\nFormCDK1 can be located to the Nucleus, cytoplasm and Mithocondria. It's cytoplasmic during interphase and reversibly translocated from cytoplasm to the nucleus when phosphorilated before G2-M transition when associated with cyclin-B1. Accumulates in mitochondria in G2-arrested cells upon DNA-damage.\n- Cdc 2 antibody\n- Cdc2 antibody\n- CDC28A antibody\nWestern blot analysis of lysates from HepG2 cells treated with Forskolin 40nM for 30 mins, using CDK1 (phospho T14) Antibody (ab58509). The lane on the right is blocked with the phospho peptide.\nImmunofluorescence analysis of COS7 cells using ab58509 at 1/1000 dilution.\nAll lanes : Anti-CDK1 (phospho T14) antibody (ab58509) at 1/500 dilution\nLane 1 : Extracts from HepG2 cells,\ntreated with Forskolin (40nM, 30mins)\nLane 2 : Extracts from HepG2 cells,\ntreated with Forskolin (40nM, 30mins), plus immunising peptide\nPredicted band size: 34 kDa\nTo our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.\nab58509 has been referenced in 1 publication.\n- Chow JP & Poon RY The CDK1 inhibitory kinase MYT1 in DNA damage checkpoint recovery. Oncogene : (2012). PubMed: 23146904", "domain": "chemistry", "round": 3} +{"url": "https://www.scienceofnad.com/nmn-versus-nr", "date": "2023-12-06T16:32:24Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100602.36/warc/CC-MAIN-20231206162528-20231206192528-00254.warc.gz", "language_score": 0.8930355906486511, "token_count": 3011, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__98521516", "lang": "en", "text": "Jul 5, 2023\nMetabolism - NMN\nInternational Journal of Molecular Sciences\nTriple-Isotope Tracing for Pathway Discernment of NMN-Induced NAD+ Biosynthesis in Whole Mice\nFeb 6, 2023\nMetabolism - Heart / Vascular - NMN - Obesity\nJournal of Clinical Endocrinology & Metabolism\nNicotinamide Adenine Dinucleotide Augmentation in Overweight or Obese Middle-Aged and Older Adults: A Physiologic Study\nPencina, Karol Mateusz\nFeb 1, 2023\nLiver - Fibrosis - Chronic Liver Disease - NMN\nNAMPT Inhibition and Increased NAD-Bioavailability Atenuate Liver Damage in CCI4-Induced Mice Liver Fibrosis\nOct 11, 2022\nNMN - Metabolism - Gut Microbiota - Bioavailability\nNicotinamide mononucleotide (NMN) deamidation by host-microbiome interactions\nAblation of the microbiome by antibiotic treatment increases the uptake and conversion of orally delivered NMN into the NAD metabolome, and that isotope labelled NMN overwhelmingly presents in intestinal tissue in the form of NR. Contrary to the assumption that exogenous NMN treatment raises NAD+ levels solely through its direct incorporation into the NAD metabolome, we show that treatment with isotope labelled NMN increases the levels of endogenous, unlabelled NAD metabolites....Given this evidence for the decomposition of NMN into free Nam prior to its uptake, a key question for the field is why downstream precursors in NAD+ synthesis such as NMN and NR lead to different outcomes compared to Nam alone...\nMay 1, 2022\nMuscle - NMN - Aging\nChronic nicotinamide mononucleotide supplementation elevates blood nicotinamide adenine dinucleotide levels and alters muscle function in healthy older men\nNMN oral supplementation at 250 mg/day in healthy older men for 12 weeks was safe and well-tolerated and significantly increased the levels of NAD + and NAD +-related metabolites in whole blood. Furthermore, NMN administration partly improved muscle performance, evaluated using gait speed and grip strength, in healthy older men...NMN did not affect the skeletal muscle mass of participants in our study...Thus, the chronic oral administration of NMN could be a therapeutic strategy for aging-related disorders in humans, such as sarcopenia.\nApr 11, 2022\nNMN - Metabolism\nFrontiers in Nutrition\nOral Administration of Nicotinamide Mononucleotide Is Safe and Efficiently Increases Blood Nicotinamide Adenine Dinucleotide Levels in Healthy Subjects\n...Previous mouse models showed that NMN administration can increase NAD+ in various organs and ameliorate aging-related diseases, such as obesity, diabetes, heart failure, stroke, kidney failure, and Alzheimer’s disease through NAD+-mediated pathways. However, evidence of its effect on humans is still scarce. In this study, we conducted a placebo-controlled, randomized, double blind, parallel-group trial to investigate the safety of orally administered NMN and its efficacy to increase NAD+ levels in thirty healthy subjects...Oral supplementation of NMN for 12 weeks caused no abnormalities in physiological and laboratory tests, and no obvious adverse effects were observed. NAD+ levels in whole blood were significantly increased after NMN administration. We also observed the significant rise in nicotinic acid mononucleotide (NAMN) levels, but not in NMN...These results suggest that oral administration of NMN is a safe and practical strategy to boost NAD+ levels in humans.\nJun 11, 2021\nNMN - Diabetes\nNicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women\nIn rodents, obesity and aging impair nicotinamide adenine dinucleotide (NAD+) biosynthesis, which contributes to metabolic dysfunction(1–8). Nicotinamide mononucleotide (NMN) availability is a rate-limiting factor in mammalian NAD+ biosynthesis. We conducted a 10-week, randomized, placebo-controlled, double-blind trial to evaluate the effect of NMN supplementation on metabolic function in postmenopausal women with prediabetes who were overweight or obese. Insulin-stimulated glucose disposal, assessed by using the hyperinsulinemic-euglycemic clamp, and skeletal muscle insulin signaling (phosphorylation of AKT and mTOR) increased after NMN supplementation, but did not change after placebo treatment. NMN supplementation up-regulated the expression of platelet-derived growth factor receptor β and other genes related to muscle remodeling. These results demonstrate NMN increases muscle insulin sensitivity, insulin signaling and remodeling in women with prediabetes who are overweight or obese.\nJun 1, 2021\nDiabetes - Neurons - Kidney - NMN\nJournal of the American Society of Nephrology\nCould NAD+ Precursor Supplements Induce a Legacy of Protection against Diabetic Nephropathy?\nHyndman, Kelly A.\nDiabetic nephropathy (DN) is a complex disease with microvascular complications, profound changes in metabolism, inflammation, and redox status, leading to structural and functional changes that can culminate in End Stage Kidney Disease (ESKD)...500NMN mice had lower mortality and significantly improved urinary albumin-creatinine ratios even at 20 weeks post-treatment compared with the db/db mice. ...Therapeutic protocols leading to legacy effects by epigenetic reprogramming of the salvage pathway to sustain or even increase kidney NAD+ show promise for slowing the development of DN.\nMar 2, 2021\nNeurons - Neurodegeneration - NMN\nSARM1 is a metabolic sensor activated by an increased NMN/NAD+ ratio to trigger axon degeneration\nFigley, Matthew D.\nApr 28, 2020\nNMN - Metabolism\nFrontiers in Cell and Developmental Biology\nNicotinamide Mononucleotide: A Promising Molecule for Therapy of Diverse Diseases by Targeting NAD+ Metabolism\nNAD+, a co-enzyme involved in a great deal of biochemical reactions, has been found to be a network node of diverse biological processes. In mammalian cells, NAD+ is synthetized, predominantly through NMN, to replenish the consumption by NADase participating in physiologic processes including DNA repair, metabolism, and cell death. Correspondingly, aberrant NAD+ metabolism is observed in many diseases. In this review, we discuss how the homeostasis of NAD+ is maintained in healthy condition and provide several age-related pathological examples related with NAD+ unbalance...The NAD+ production and consumption pathways including NMN are essential for more precise understanding and therapy of age-related pathological processes such as diabetes, ischemia–reperfusion injury, heart failure, Alzheimer’s disease, and retinal degeneration.\nFeb 1, 2020\nAging - NMN\nThe Science Behind NMN–A Stable, Reliable NAD+Activator and Anti-Aging Molecule\nBy middle age, our NAD+ levels have plummeted to half that of our youth. Numerous studies have demonstrated that boosting NAD+ levels increases insulin sensitivity, reverses mitochondrial dysfunction, and extends lifespan....NMN can be converted by the body to NR, which then enters cells, and is converted back to NMN by an enzyme called nicotinamide riboside kinase (NRK).\nJul 12, 2019\nNMN Transporter - Bioavailability\nAbsence of evidence that Slc12a8 encodes a nicotinamide mononucleotide transporter\nDespite genetic, pharmacological and kinetic evidence validated by a quantitative assay showing that nicotinamide mononucleotide (NMN) is dephosphorylated to nicotinamide riboside before cellular internalization1 , solute carrier family 12 member 8 (Slc12a8), which is widely expressed and annotated as a Na+/K+ Cl− transporter, has been nominated to be an NMN transporter. The analytical methods, transport data and interpretation underlying this assignment are not sound and do not support transport of NMN by Slc12a8.\nFeb 28, 2019\nLeigh Syndrome - Neurons - Mitochondria - NMN\nTargeting NAD+ Metabolism as Interventions for Mitochondrial Disease\nLee, Chi Fung\nMar 22, 2018\nHeart ⎼ Vascular Aging (NMN)\nImpairment of an endothelial NAD+‐H2S signaling network is a reversible cause of vascular aging\nA decline in capillary density and blood flow with age is a major cause of mortality and morbidity. Understanding why this occurs is key to future gains in human health. NAD precursors reverse aspects of aging, in part, by activating sirtuin deacylases (SIRT1–SIRT7) that mediate the benefits of exercise and dietary restriction (DR). We show that SIRT1 in endothelial cells is a key mediator of pro-angiogenic signals secreted from myocytes. Treatment of mice with the NAD+ booster nicotinamide mononucleotide (NMN) improves blood flow and increases endurance in elderly mice by promoting SIRT1-dependent increases in capillary density, an effect augmented by exercise or increasing the levels of hydrogen sulfide (H2S), a dietary restriction mimetic and regulator of endothelial NAD+ levels. These findings have implications for improving blood flow to organs and tissues, increasing human performance, and reestablishing a virtuous cycle of mobility in the elderly.\nMar 2, 2017\nNeurons - NMN\nNMN Deamidase Delays Wallerian Degeneration and Rescues Axonal Defects Caused by NMNAT2 Deficiency In Vivo\nDi Stephano, Michelle\nOur data strongly support an in vivo role for NMN accumulation in triggering axon degeneration both after injury and when NMNAT2 is constitutively depleted, with axon protection by WLDs /NMNATs and NMN deamidase in both situations at least partially relying on their ability to limit NMN accumulation.\nOct 27, 2016\nAging - NMN\nLong-Term Administration of Nicotinamide\nMononucleotide Mitigates Age-Associated\nPhysiological Decline in Mice\nMills, Kathryn F.\nWe found that a 12-month-long NMN administration (1) is well-tolerated without any obvious deleterious effects, (2) suppresses age-associated body weight gain, (3) enhances food intake, oxygen consumption, energy expenditure, and physical activity, (4) improves insulin sensitivity and plasma lipid profile, independent of its effect on body weight, and (5) improves eye function, bone density, and myeloid-lymphoid composition. NMN administration was also able to prevent age-associated gene expression changes in a tissue-dependent manner and enhance mitochondrial respiratory capability in skeletal muscle.\nOct 11, 2016\nBioavailability - NMN\nNRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells\nNAD+ is a vital redox cofactor and a substrate required for activity of various enzyme families, including sirtuins and poly(ADP-ribose) polymerases. Supplementation with NAD+ precursors, such as nicotinamide mononucleotide (NMN) or nicotinamide riboside (NR), protects against metabolic disease, neurodegenerative disorders and age-related physiological decline in mammals. Here we show that nicotinamide riboside kinase 1 (NRK1) is necessary and rate-limiting for the use of exogenous NR and NMN for NAD+ synthesis. Using genetic gain- and loss-of-function models, we further demonstrate that the role of NRK1 in driving NAD+ synthesis from other NAD+ precursors, such as nicotinamide or nicotinic acid, is dispensable. Using stable isotope-labelled compounds, we confirm NMN is metabolized extracellularly to NR that is then taken up by the cell and converted into NAD+. Our results indicate that mammalian cells require conversion of extracellular NMN to NR for cellular uptake and NAD+ synthesis, explaining the overlapping metabolic effects observed with the two compounds.\nApr 24, 2015\nNeurons - NMN\nSARM1 activation triggers axon degeneration locally via NAD+ destruction\nTogether these data implicate NAD+ loss as a critical step in SARM1-mediated axon destruction...axon degeneration and cell death were blocked by supplementation with the cell-permeable NAD+ precursor Nicotinamide Riboside (NR)...Cells undergo regulated self-destruction during development and in response to stresses...these data implicate NAD+ loss as a critical step in SARM1-mediated axon destruction...Rapid NAD+ depletion is sufficient to cause rapid axon loss...\nOct 17, 2014\nNeurons - NMN\nCell Death and Differentiation\nA rise in NAD precursor nicotinamide mononucleotide (NMN) after injury promotes axon degeneration\nDi Stefano, M\n...Here we show that the nucleotide precursor of NAD, nicotinamide mononucleotide (NMN), accumulates after nerve injury and promotes axon degeneration. Inhibitors of NMN-synthesising enzyme NAMPT confer robust morphological and functional protection of injured axons and synapses despite lowering NAD. Exogenous NMN abolishes this protection, suggesting that NMN accumulation within axons after NMNAT2 degradation could promote degeneration...These data indicate that the mechanism by which NMNAT and the related WldS protein promote axon survival is by limiting NMN accumulation. They indicate a novel physiological function for NMN in mammals and reveal an unexpected link between new strategies for cancer chemotherapy and the treatment of axonopathies.\nMar 26, 2010\nNeurons - NMN\nAnnual Review of Neuroscience\nWallerian Degeneration, WldS, and Nmnat\nColeman, Michael P.\nDespite the importance of extra-axonal support for long-term survival, axons are now thought to initiate their own degeneration when these systems fail. Moreover, the trigger is not a general lack of nutrients. Injured axons appear to self-destruct through a regulatable or active process that is distinct from apoptosis", "domain": "chemistry", "round": 3} +{"url": "https://www.prospecbio.com/lmna-human", "date": "2023-09-23T23:12:43Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233506539.13/warc/CC-MAIN-20230923231031-20230924021031-00393.warc.gz", "language_score": 0.7187098860740662, "token_count": 840, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__194632074", "lang": "en", "text": "Prelamin-A/C, Lamin-A/C, 70 kDa lamin, LMNA, LMN1, Renal carcinoma antigen NY-REN-32, Progerin.\nLamin-A is a major component of the nuclear lamina, a dynamic meshwork located just under the nuclear envelope and it is encoded by lamin A/C gene (LMNA).\nLamin-A is synthesized as Prelamin A, a longer precursor that in vivo goes through a serial post-translational modifications that lead to mature Lamin A.\nDiverse mutations in the Lamin A/C gene are associated with different diseases that are collectively called laminophaties, including Emery-Dreifuss muscular dystrophy, familiar partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome.\nLMNA Human Recombinant fused with a His tag produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 614 amino acids and having a molecular mass of 68.0kDa. The LMNA is purified by proprietary chromatographic techniques.\nThe LMNA solution contains 20mM Tris-HCl pH 7.5, 1mM DTT, 0.5M NaCl, 1.5mM EDTA and 20%(v/v) glycerol.\nStore at 4°C if entire vial will be used within 2-4 weeks.\nStore, frozen at -20°C for longer periods of time.\nFor long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).\nAvoid multiple freeze-thaw cycles.\nGreater than 90.0% as determined by SDS-PAGE.\nAmino acid sequence\nMAHHHHHHVG TGSNDDDDKS PDMETPSQRR ATRSGAQASS TPLSPTRITR LQEKEDLQEL NDRLAVYIDR VRSLETENAG LRLRITESEE VVSREVSGI KAAYEAELGD ARKTLDSVAK ERARLQLELS KVREEFKELK ARNTKKEGDL IAAQARLKDL EALLNSKEAA LSTALSEKRT LEGELHDLRG QVAKLEAALG EAKKQLQDEM LRRVDAENRL QTMKEELDFQ KNIYSEELRE TKRRHETRLV EIDNGKQREF ESRLADALQE LRAQHEDQVE QYKKELEKTY SAKLDNARQS AERNSNLVGA AHEELQQSRI RIDSLSAQLS QLQKQLAAKE AKLRDLEDSL ARERDTSRRL LAEKEREMAE MRARMQQQLD EYQELLDIKL ALDMEIHAYR KLLEGEEERL RLSPSPTSQR SRGRASSHSS QTQGGGSVTK KRKLESTESR SSFSQHARTS GRVAVEEVDE EGKFVRLRNK SNEDQSMGNW QIKRQNGDDP LLTYRFPPKF TLKAGQVVTI WAAGAGATHS PPTDLVWKAQ NTWGCGNSLR TALINSTGEE VAMRKLVRSV TVVEDDEDED GDDLLHHHHG SHCSSSGDPA EYNLRSRTVL CGTCGQPADK ASASGSGAQS PQNCSIM", "domain": "chemistry", "round": 3} +{"url": "https://innovareacademics.in/journals/index.php/ijs/article/view/38552", "date": "2022-09-26T10:01:21Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-40/segments/1664030334855.91/warc/CC-MAIN-20220926082131-20220926112131-00203.warc.gz", "language_score": 0.6947182416915894, "token_count": 1435, "dump": "CC-MAIN-2022-40", "global_id": "webtext-fineweb__CC-MAIN-2022-40__0__293298454", "lang": "en", "text": "“STRUCTURAL PROPERTIES OF HOLMIUM DOPED COBALT FERRITE BY STANDARD CERAMIC TECHNIQUE”\nKeywords:Cobalt ferrite, Rare earth, Structural properties\nObjective: Compositions of CoHoxFe2-xO4 (x = 0.00 and 0.02) was prepared by standard ceramic technique using AR grade CoO2, Ho2O3 and Fe2O3. The samples were characterized by X-ray diffraction technique and the analysis of XRD patterns reveals the formation of single phase cubic spinel structure. The structural parameters like lattice constant (a), x- ray density(dx), bulk density (dB), particle size (t) and porosity (P), tetrahedral and octahedral bondlength (dAX and dBX), the tetrahedral edge (dAXE), and the shared and unshared octahedral edge (dBEX and dBXEU) can be calculated were calculated form XRD data and effect of Ho3+ doped cobalt ferrite was studied. Thus, the rare earth Ho3+ doped cobalt ferrite strongly influences the physical properties of cobalt ferrite.\nMaterials and Methods: Present series was prepared by standard ceramic technique using AR grade CoO2, Ho2O3 and Fe2O3.\nResults: The XRD pattern shows that both the samples possess single phase cubic spinel structure. No extra peak of Ho3+ is observed for x =0.02 sample. Lattice constant, X-ray density of Ho3+ doped cobalt ferrite is increases than that of pure cobalt ferrite.\nConclusion: The rare earth Ho3+ doped cobalt ferrite strongly influences the physical properties of cobalt ferrite.\n2. X. Lu, G. Liang, Q. Sun, C. Yang. J. Mater. Let. 65 (2011) 674.\n3. P. K. Gaikwad, V. S. Shinde and S. S. Sawant, Int. Res. J. of Science and Engineering. Special Issue A5: XX-XX (2018)1-4.\n4. P. K. Gaikwad, Int. J. of Eng. and Adv. Dev. Vol-4 Jan (2018) 58- 63.\n5. B.G. Toksha, S.E. Shirsath, S.M. Patange and K.M. Jadhav. Solid State Commun. 147 (2008) 479.\n6. Ying Zhang and Dijiang Wen. Mater. Sci. Eng. B. 172 (2010) 331.\n7. A. A. Sattar and A. M. Samy. J. Mater. Sci. 37 (2002) 4499.\n8. Mansor Al-Haj. J. Magn. Magn. Mater 299(2006) 435.\n9. M. Z. Said. Mater. Lett. 34 (1998) 305.\n10. M. Ishaque, M. U. Islam, M. A. Khan, I. Z. Rahman, A. Genson and S. Hampshire.Physica B 405 (2010) 1532.\n11. I. P. Muthuselvan and R. N. Bhowmik. J. Magn. Magn. Mater. 322 (2010) 767.\n12. J. Peng, M. Hojamberdiv, Y. Xu, B. Cao, J. Wang and H. Wu.J. Magn. Magn. Mater. 323 (2011) 133.\n13. M. L. Kahn and Z. H. Zhang. Appl. Phys. Lett. 78 (2001).\n14. L. Zhao, H. Yang and L. Lu. J. Mater. Sci.19 (2008) 992.\n15. L. Zhao, H. Yang, X. Zhao, L. Cui and S. Feng. Mater. Lett. 60 (2006) 1.\n16. C. N. Rao “Chemical approaches to the synthesis of inorganic materials”Wiley, New York (1994)\n17. P. K. Gaikwad, S. S. Sawant and K. M. Jadhav, J. Adv. App. Sci. Tech. Vol. 1 Issue 2 Dec (2014) 35-37.\n18. S. Jie, W. Lixi, Xu Naicen and Z. Qitu.J. Rare Earths 28 (2010) 451.\n19. I. Ali, M. U. Islam, M. Ishaque, H. M. Khan, M. N. Ashiq, M. U. Rana J. Mag. Mag. Mat. 324 (2012) 3773–3777\n20. P. K. Gaikwad, S. S. Sawant, G. B. Jadhav and K. M. Jadhav, Golden Res. Thoughts Vol. 2 Issue 7 Jan (2013) 8-13.\n21. J. Jiang, Y. Yang and L. Li. Physica B. 399 (2007) 105.\n22. P. K. Roy, B. B. Nayak and J. Bera.J. Magn. Magn. Mater 320 (2008) 1128.\n23. T. J. Shinde, A. B. Gadkari and P. N. Yasambekar.J. Mater. Sci. Mater Electron 21 (2010) 120.\n24. Y. Yanmin, J. Jing, L. Liangchao and X. Yanlong. J. Rare Earths 25 (2007) 228.\n25. J. Jiang, L. Li, F. Xu and Y. Xie.Mater. Sci. Eng. B. 137 (2007) 166.\n26. K. K. Bharathi, J. A. Chelvane and G. Markandeyulu. J. Magn. Magn. Mater 321 (2009) 3677.\n27. B. D. Cullity, “Elements of X-ray diffraction” Addison –Wesley Pub. Com. Inc (1956)\n28. M. A. Ahmed, E, Ateia, S.I. E1-Dek.Mater. Letts 57(2003) 4256.\n29. P. K. Roy, J. Bera. Mater. Res. Bull. 42 (2007) 77\n30. J. Jiang, Y. M. Yang and L. C. Li Physica B 399 (2010) 451.", "domain": "chemistry", "round": 3} +{"url": "https://bulletin.chemwatch.net/technical/common-polymorphisms-in-the-solute-carrier-slc30a10-are-associated-with-blood-manganese-and-neurological-function", "date": "2023-02-06T17:03:52Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-06/segments/1674764500356.92/warc/CC-MAIN-20230206145603-20230206175603-00581.warc.gz", "language_score": 0.9103938341140747, "token_count": 512, "dump": "CC-MAIN-2023-06", "global_id": "webtext-fineweb__CC-MAIN-2023-06__0__30462310", "lang": "en", "text": "Manganese (Mn) is an essential nutrient in humans, but excessive exposure to Mn may cause neurotoxicity. Despite homeostatic regulation, Mn concentrations in blood vary considerably among individuals. The authors evaluated if common single-nucleotide polymorphisms (SNPs) in SLC30A10, which likely encodes a Mn transporter, influence blood Mn concentrations and neurological function. The blood Mn concentrations were measured by ICP-MS or atomic absorption spectroscopy and genotyped two SLC30A10 non-coding SNPs (rs2275707 and rs12064812) by TaqMan PCR in cohorts from Bangladesh (N=406), the Argentinean Andes (N=198), and Italy (N=238). In addition, the authors measured SLC30A10 expression in whole blood by TaqMan PCR in a sub-group (N=101) from the Andean cohort, and neurological parameters (sway velocity and finger-tapping speed) in the Italian cohort. The rs2275707 variant allele was associated with increased Mn concentrations in the Andes (8%, p=0.027) and Italy (10.6%, p=0.012), but not as clear in Bangladesh (3.4%, p=0.21; linear regression analysis adjusted for age, gender, and plasma ferritin). This allele was also associated with increased sway velocity (15%, p=0.033; adjusted for age and sex) and reduced SLC30A10 expression (-24.6%, p=0.029). By contrast, the rs12064812 variant homozygous genotype was associated with reduced Mn concentrations, particularly in the Italian cohort (-18.4%, p=0.04), and increased finger-tapping speed (8.7%, p=0.025). The results show that common SNPs in SLC30A10 are associated with blood Mn concentrations in three unrelated cohorts and that their influence may be mediated by altered SLC30A10 expression. Moreover, the SNPs appeared to influence neurological functions independent of blood Mn concentrations, suggesting that SLC30A10 could regulate brain Mn levels.\nAuthors: Wahlberg K, Kippler M, Alhamdow A, Rahman SM, Smith DR, Vahter M, Lucchini R, Broberg K. ;Full Source: Toxicological Science. 2015 Dec 1. pii: kfv252. [Epub ahead of print] ;", "domain": "chemistry", "round": 3} +{"url": "http://www.lipomics.com/resources/publications/basic-research-2015/daniels,-i-s,-et-al,-a-role-of-erythrocytes-in-adenosine.aspx", "date": "2017-10-20T09:07:18Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-43/segments/1508187823997.21/warc/CC-MAIN-20171020082720-20171020102720-00144.warc.gz", "language_score": 0.9233738780021667, "token_count": 438, "dump": "CC-MAIN-2017-43", "global_id": "webtext-fineweb__CC-MAIN-2017-43__0__189787578", "lang": "en", "text": "Daniels, I S, et al., A Role of Erythrocytes in Adenosine Monophosphate Initiation of Hypometabolism in Mammals. J Biol Chem, 2010. 285(27): 20716-23.\nBiochemical and mechanistic aspects into how various hypometabolic states are initiated in mammals are poorly understood. Here, we show how a state of hypometabolism is initiated by 5'-AMP uptake by erythrocytes. Wild type, ecto-5'-nucleotidase-deficient, and adenosine receptor-deficient mice undergo 5'-AMP-induced hypometabolism in a similar fashion. Injection of 5'-AMP leads to two distinct declining phases of oxygen consumption (VO(2)). The phase I response displays a rapid and steep decline in VO(2) that is independent of body temperature (T(b)) and ambient temperature (T(a)). It is followed by a phase II decline that is linked to T(b) and moderated by T(a). Altering the dosages of 5'-AMP from 0.25- to 2-fold does not change the phase I response. For mice, a T(a) of 15 degrees C is effective for induction of DH with the appropriate dose of 5'-AMP. Erythrocyte uptake of 5'-AMP leads to utilization of ATP to synthesize ADP. This is accompanied by increased glucose but decreased lactate levels, suggesting that glycolysis has slowed. Reduction in glycolysis is known to stimulate erythrocytes to increase intracellular levels of 2,3-bisphosphoglycerate, a potent allosteric inhibitor of hemoglobin's affinity for oxygen. Our studies showed that both 2,3-bisphosphoglycerate and deoxyhemoglobin levels rose following 5'-AMP administration and is in parallel with the phase I decline in VO(2). In summary, our investigations reveal that 5'-AMP mediated hypometabolism is probably triggered by reduced oxygen transport by erythrocytes initiated by uptake of 5'-AMP.", "domain": "chemistry", "round": 3} +{"url": "https://www.bioz.com/search/mek1/2", "date": "2020-11-26T23:13:52Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-50/segments/1606141189030.27/warc/CC-MAIN-20201126230216-20201127020216-00373.warc.gz", "language_score": 0.8826881647109985, "token_count": 713, "dump": "CC-MAIN-2020-50", "global_id": "webtext-fineweb__CC-MAIN-2020-50__0__15266083", "lang": "en", "text": "Article Title: The role of estrogen receptors in rat Sertoli cells at different stages of development\nFigure Lengend Snippet: Effects of proteins kinases inhibitors on the expression of non-phosphorylated CTNNB induced by DPN in the Sertoli cells from 20-day-old rats . Sertoli cells from 20-day-old rats were incubated in the absence (C, control) and presence of DPN (10 nM) for 24 h. The cells were also untreated or pretreated with PP2, an inhibitor of the SRC family of protein tyrosine kinases; U0126, an inhibitor of MEK1/2; Wortmannin, an inhibitor of PI3K and MK-2206, an inhibitor of AKT for 30 min. Afterward, the cells were stimulated with DPN (10 nM) 24h. Immunostaining for CTNNB (green) was detected using an antibody specific for non-phosphorylated CTNNB and Alexa Fluor 488-labeled secondary antibody. Nuclei were stained with DAPI (blue). Negative control was performed using normal rabbit serum at the same dilution of antibody. Scale bar as indicated. The data shown are representative of three independent experiments. Note: Control, C, and DPN are the same results of the Figure 5 . All treatments were performed on the same day (Figures 5 and 6 ).\nArticle Snippet: The cells were also untreated or pretreated with ESR2-selective antagonist PHTPP (4-(2-phenyl-5,7-bis(trifluoromethyl)pyrazolo(1,5-a)pyrimidin-3-yl)phenol; 10 nM; Tocris Bioscience), the selective inhibitor of the SRC family of protein tyrosine kinases PP2 (4-amino-5-(4-chlorophenyl)-7-(t-butyl) pyrazolo[3,4-d]pyrimidine; 5 nM; Calbiochem, Darmstadt, Germany), MEK1/2 inhibitor U0126 (1,4-diamino-2,3-dicyano-1,4-bis[2- aminophenylthio] butadiene; 20 μM; Cell Signaling Technology), PI3K inhibitor Wortmannin (11-(acetyloxy)-1S,6bR,7,8,9aS,10,11R,11bR-octahydro-1-(methoxymethyl)-9a,11b-dimethyl-3H-furo[4,3,2-de]indeno[4,5-h]-2- benzopyran-3,6,9-trione; 100 nM; Sigma Chemical Co.) or AKT inhibitor MK-2206 (8-(4-(1-aminocyclobutyl)phenyl)-9-phenyl-[1,2,4]triazolo[3,4-f][1,6]naphthyridin-3(2H)-one; 200 nM; Selleckchem, Houston, TX, USA) for 30 min.\nTechniques: Expressing, Incubation, Immunostaining, Labeling, Staining, Negative Control", "domain": "chemistry", "round": 3} +{"url": "http://lubrilabbc.com/fuel-oil-additives/", "date": "2024-02-21T04:39:44Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707947473370.18/warc/CC-MAIN-20240221034447-20240221064447-00837.warc.gz", "language_score": 0.9136761426925659, "token_count": 345, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__155013787", "lang": "en", "text": "Fuel & Oil Additives for Industry\nLubri-Lab has over the years developed specialty products designed to improve the quality, longevity and functionality of the various fluids used by industry. While it may not always be necessary to move to bio-degradable fluids as outlined in our Bio-Tope series of products, Lubri-Lab BC carries a complete line of additives which regardless of the scenario improve the lubricity and operational functions of your equipment.\nAdditives for Gear Oil and Manual Transmissions\nAdditive for Gear Oil and Manual Transmissions. Ultra G™ extends life and reduces friction and noise in power transmission systems.\nAdditive for Hydraulic Oil and Automatic Transmissions. Multi 1™ maintains the viscosity of oil under extreme conditions of work and heat.\nMarine Gear Additive developed specifically for marine drives, Z-Drives & pumps and other water or moisture intensive applications.\nIn addition to the above, some of the most common Additives include:\nDiesel Fuel Conditioner XTRA DIESEL™ improves the overall performance of Diesel fuel. It improves fuel economy by as much as 2.8% while cleaning the fuel system, eliminating deposits, algae and water.\nGasoline Additive Detona+™ protects the fuel distribution system from corrosion and rust, reduces deposits in combustion chamber and intake valves and reduces emissions. In addition, it will optimize fuel economy and engine performance and improves power and acceleration.\nConcentrated Engine Oil Treatment, Integral 7 is an additive specially formulated for use in both gasoline and diesel engines. Integral 7 improves the power and efficiency of all engines but in particular older engines resulting in increased life of the engine and less maintenance.", "domain": "chemistry", "round": 3} +{"url": "http://eprints.qut.edu.au/73750/", "date": "2017-05-01T02:49:02Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-17/segments/1492917126538.54/warc/CC-MAIN-20170423031206-00634-ip-10-145-167-34.ec2.internal.warc.gz", "language_score": 0.860934853553772, "token_count": 480, "dump": "CC-MAIN-2017-17", "global_id": "webtext-fineweb__CC-MAIN-2017-17__0__48485927", "lang": "en", "text": "Effect of hydrophilicity of carbon nanotube arrays on the release rate and activity of recombinant human bone morphogenetic protein-2\nHan, Zhao Jun, Ostrikov, Kostya, Tan, Cher Ming, Tay, Beng Kang, & Peel, Sean A.F. (2011) Effect of hydrophilicity of carbon nanotube arrays on the release rate and activity of recombinant human bone morphogenetic protein-2. Nanotechnology, 22(29), p. 295712.\nNovel nanostructures such as vertically aligned carbon nanotube (CNT) arrays have received increasing interest as drug delivery carriers. In the present study, two CNT arrays with extreme surface wettabilities are fabricated and their effects on the release of recombinant human bone morphogenetic protein-2 (rhBMP-2) are investigated. It is found that the superhydrophilic arrays retained a larger amount of rhBMP-2 than the superhydrophobic ones. Further use of a poloxamer diffusion layer delayed the initial burst and resulted in a greater total amount of rhBMP-2 released from both surfaces. In addition, rhBMP-2 bound to the superhydrophilic CNT arrays remained bioactive while they denatured on the superhydrophobic surfaces. These results are related to the combined effects of rhBMP-2 molecules interacting with poloxamer and the surface, which could be essential in the development of advanced carriers with tailored surface functionalities.\nImpact and interest:\nCitation counts are sourced monthly from and citation databases.\nThese databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.\nCitations counts from theindexing service can be viewed at the linked Google Scholar™ search.\n|Item Type:||Journal Article|\n|Divisions:||Current > QUT Faculties and Divisions > Science & Engineering Faculty|\n|Deposited On:||10 Jul 2014 04:56|\n|Last Modified:||11 Jul 2014 02:44|\nRepository Staff Only: item control page", "domain": "chemistry", "round": 3} +{"url": "https://asep.lib.cas.cz/arl-cav/sk/detail-cav_un_epca-0369494-Inhibitors-of-Succinate-Quinone-ReductaseComplex-II-Regulate-Production-of-Mitochondrial-Reactive/", "date": "2017-09-26T18:22:17Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-39/segments/1505818696677.93/warc/CC-MAIN-20170926175208-20170926195208-00542.warc.gz", "language_score": 0.6756558418273926, "token_count": 475, "dump": "CC-MAIN-2017-39", "global_id": "webtext-fineweb__CC-MAIN-2017-39__0__131267080", "lang": "en", "text": "Počet záznamů: 1\nInhibitors of Succinate: Quinone Reductase/Complex II Regulate Production of Mitochondrial Reactive Oxygen Species and Protect Normal Cells from Ischemic Damage but Induce Specific Cancer Cell Death\n0369494 - BTO-N 2012 RIV US eng J - Článek v odborném periodiku\nRalph, S.J. - Moreno-Sanchez, R. - Neužil, Jiří - Rodriguez-Enriquez, S.\nInhibitors of Succinate: Quinone Reductase/Complex II Regulate Production of Mitochondrial Reactive Oxygen Species and Protect Normal Cells from Ischemic Damage but Induce Specific Cancer Cell Death.\nPharmaceutical Research. Roč. 28, č. 11 (2011), s. 2695-2730 ISSN 0724-8741\nVýzkumný záměr: CEZ:AV0Z50520701\nKlíčová slova: Mitocans * SDH/Complex II * mitochondrial ROS production\nKód oboru RIV: CE - Biochemie\nImpakt faktor: 4.093, rok: 2011\nSuccinate:quinone reductase (SQR) of Complex II, occupying a unique central point in the mitochondrial respiratory system as a major source of electrons driving reactive oxygen species (ROS) production, is an ideal pharmaceutical target for modulating ROS levels in normal cells to prevent oxidative stress-induced damage or increase ROS in cancer cells, inducing cell death. Value of drugs like diazoxide to prevent ROS production, protecting normal cells, while vitamin E analogues promote ROS in cancer cells to kill them, is highlighted. We collate and discuss diverse sources of information relating to ROS production in different biological systems, focussing on evidence for SQR as main source of ROS production in mitochondria, particularly its relevance to protection from oxidative stress and to mitochondrial-targeted anticancer drugs (mitocans) as novel cancer therapies.\nTrvalý link: http://hdl.handle.net/11104/0006745", "domain": "chemistry", "round": 3} +{"url": "https://rxdrugs24.com/balkan-pharmaceuticals/testosterone-p", "date": "2020-05-31T10:47:54Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-24/segments/1590347413097.49/warc/CC-MAIN-20200531085047-20200531115047-00346.warc.gz", "language_score": 0.9389827251434326, "token_count": 314, "dump": "CC-MAIN-2020-24", "global_id": "webtext-fineweb__CC-MAIN-2020-24__0__74499583", "lang": "en", "text": "Propionate - one of the testosterone esters. It is popular among athletes for several reasons. Community - is its cheapness. It is the cheapest testosterone.\nTestosterone P 100 mg/ml\nProduct: Testosterone P\nProduct Code: 2209\nActive Ingredient: TESTOSTERONE PROPIONATE\nManufacturer: Balkan Pharmaceuticals\nQuantity: 5 ampoules\nStrenght: 100 mg/ml\nThe second reason is that less than their counterparts propionate exhibits side effects of androgens, such as edema, accumulation of subcutaneous fat, ... What is extremely important during the \"drying\". But at the same time, the drug increases the body's ability to recovery even if the low-carb diet and does not fall power indicators.\nThe main difference of testosterone propionate enanthate and cypionate from - it's expiration date. Propionate - the shorter of testosterone esters.\nSide effects of testosterone propionate are similar to the side effects of enanthate and cypionate, but they occur much less frequently. Despite this with genetic predisposition, as well as excessively high doses there is a probability of occurrence of such androgen-related side effects: acne, hair loss, hair growth on the body. Testosterone propionate is often increases libido in men and women taking the drug. Gynecomastia while taking propionate appears much less than when other testosterone esters, accumulation of fluid also less pronounced.", "domain": "chemistry", "round": 3} +{"url": "https://sciencesources.eurekalert.org/bysubject/index.php?kw=75", "date": "2020-09-30T15:54:42Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-40/segments/1600402127075.68/warc/CC-MAIN-20200930141310-20200930171310-00695.warc.gz", "language_score": 0.9283642172813416, "token_count": 590, "dump": "CC-MAIN-2020-40", "global_id": "webtext-fineweb__CC-MAIN-2020-40__0__10706618", "lang": "en", "text": "A team of ICFO researchers develops a new class of broadband solid state light emitter in the short-wave infrared that could be miniaturized, integrated with CMOS technology and used for many applications including food inspection, health or safety.\nScientists typically prefer to work with ordered systems. However, a diverse team of physicists and biophysicists from the University of Groningen found that individual light-harvesting nanotubes with disordered molecular structures still transport light energy in the same way. By combining spectroscopy, molecular dynamics simulations and theoretical physics, they discovered how disorder at the molecular level is effectively averaged out at the microscopic scale.\nResearchers have registered the formation of silver nanoparticles in an ion-exchanged glass as a result of infrared laser irradiation. The research of current studies were published in the journal of Nanomaterials.\nBiometric authentication, which uses unique anatomical features such as fingerprints or facial features to verify a person's identity, is increasingly replacing traditional passwords for accessing everything from smartphones to law enforcement systems.\nResearchers have established a novel high-frequency laser facility at the University of Tokyo. The coherent extreme ultraviolet light source can reveal details of biological or physical samples with unprecedented clarity. It also allows for investigation of time-dependent phenomena such as ultrafast chemical reactions. Existing facilities for such investigations necessarily require enormous particle accelerators and are prohibitive to many researchers. This new facility should greatly improve access for a broad range of researchers.\nScientists led by the Institute of Industrial Science at the University of Tokyo used computer simulations to better understand the mechanical transition in glassy materials. They found that a system-wide network provides the backbone that gives glass its strength. This work may lead to advances in the production of stronger glass for smartphones and other applications.\nSince these early days of quantum mechanics, it is known that photons also possess momentum. The photon's ability to transfer momentum was used in a novel approach by scientists of the Max Born Institute, Uppsala University, and the European X-Ray Free-Electron Laser Facility to observe a fundamental process in the interaction of x-rays with atoms. The detailed experimental and theoretical results are reported in the journal Science.\nThe Hyperspectral Stripe Projector captures spectroscopic and 3D imaging data for applications like machine vision, crop monitoring, self-driving cars and corrosion detection.\nResearchers at the National Institute of Standards and Technology (NIST) have devised and demonstrated a system that could dramatically increase the performance of communications networks while enabling record-low error rates in detecting even the faintest of signals.\nThe colloidal diamond could make light waves as useful as electrons in computing, and hold promise for a host of other applications. Researchers let by NYU Tandon Professor David Pine have devised a new process for the reliable self-assembly of colloids in a diamond formation that could lead to cheap, scalable fabrication of such structures.", "domain": "chemistry", "round": 3} +{"url": "http://www.mdpi.com/2079-4991/1/1/3/xml", "date": "2018-02-23T12:58:38Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-09/segments/1518891814700.55/warc/CC-MAIN-20180223115053-20180223135053-00566.warc.gz", "language_score": 0.7999936938285828, "token_count": 402, "dump": "CC-MAIN-2018-09", "global_id": "webtext-fineweb__CC-MAIN-2018-09__0__240289479", "lang": "en", "text": "Films, Buckypapers and Fibers from Clay, Chitosan and Carbon Nanotubes\nAbstractThe mechanical and electrical characteristics of films, buckypapers and fiber materials from combinations of clay, carbon nanotubes (CNTs) and chitosan are described. The rheological time-dependent characteristics of clay are maintained in clay–carbon nanotube–chitosan composite dispersions. It is demonstrated that the addition of chitosan improves their mechanical characteristics, but decreases electrical conductivity by three-orders of magnitude compared to clay–CNT materials. We show that the electrical response upon exposure to humid atmosphere is influenced by clay-chitosan interactions, i.e., the resistance of clay–CNT materials decreases, whereas that of clay–CNT–chitosan increases. View Full-Text\nScifeed alert for new publicationsNever miss any articles matching your research from any publisher\n- Get alerts for new papers matching your research\n- Find out the new papers from selected authors\n- Updated daily for 49'000+ journals and 6000+ publishers\n- Define your Scifeed now\nHiggins, T.M.; Warren, H.; Panhuis, M. Films, Buckypapers and Fibers from Clay, Chitosan and Carbon Nanotubes. Nanomaterials 2011, 1, 3-19.\nHiggins TM, Warren H, Panhuis M. Films, Buckypapers and Fibers from Clay, Chitosan and Carbon Nanotubes. Nanomaterials. 2011; 1(1):3-19.Chicago/Turabian Style\nHiggins, Thomas M.; Warren, Holly; Panhuis, Marc in het. 2011. \"Films, Buckypapers and Fibers from Clay, Chitosan and Carbon Nanotubes.\" Nanomaterials 1, no. 1: 3-19.", "domain": "chemistry", "round": 3} +{"url": "https://tohoku.pure.elsevier.com/en/publications/strengthening-of-low-youngs-modulus-beta-ti-nb-sn-alloys-by-therm", "date": "2022-08-18T10:27:49Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882573193.35/warc/CC-MAIN-20220818094131-20220818124131-00472.warc.gz", "language_score": 0.8978391885757446, "token_count": 336, "dump": "CC-MAIN-2022-33", "global_id": "webtext-fineweb__CC-MAIN-2022-33__0__207056504", "lang": "en", "text": "Young's modulus of quenched beta Ti-Nb-Sn alloys was investigated as a function of alloy composition. It was found that a minimum of Young's modulus appears at a composition in an unstable beta phase where a thermal omega phase transformation as well as martensitic transformation is almost completely suppressed. Based on this result, quenched beta Ti-Nb-Sn alloys with low Young's modulus were cold-rolled and heat-treated to evolve various micro-structures. Orthorhombic martensite is stress-induced by cold rolling in a Ti-Nb-Sn alloy having Ms just below room temperature. With increasing rolling reduction, the volume fraction of martensite increases and most martensite plates become parallel to the rolling direction. With increasing temperature, reverse martensitic transformation starts above room temperature, proceeds gradually, and finishes at about 250°C, thereby yielding very fine beta-phase grains elongated to the rolling direction. A high density of dislocations and fine alpha precipitates are included in the beta grains. With further increasing temperature the alpha phase precipitation occurs significantly, leading to increases in strength and Young's modulus. Low Young's modulus and high strength are simultaneously attained by controlling the heat treatment condition.\n|Number of pages||1|\n|Specialist publication||Advanced Materials and Processes|\n|Publication status||Published - 2005 Jul 1|\nASJC Scopus subject areas\n- Materials Science(all)\n- Mechanics of Materials\n- Mechanical Engineering", "domain": "chemistry", "round": 3} +{"url": "http://careersfromscience.org/2018/10/31/the-gene-encodes-a-mitochondrial-glutaminase-thats-highly-expressed-in-mind/", "date": "2023-12-08T23:08:26Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100779.51/warc/CC-MAIN-20231208212357-20231209002357-00187.warc.gz", "language_score": 0.8773050308227539, "token_count": 1244, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__126045887", "lang": "en", "text": "The gene encodes a mitochondrial glutaminase that’s highly expressed in mind, kidney, small intestine and several transformed cells. from the potential ramifications of N-acetylation, the corresponding lysine to alanine mutations had been built in the hGAC1 plasmid. The outrageous type and mutated proteins had been purified by Ni+-affinity chromatography and their phosphate activation and BPTES inhibition information had been analyzed. Two from the alanine substitutions informed portion (K311A and K328A) and the main one in the dimer:dimer user interface (K396A) type enzymes that want better concentrations of phosphate to create half-maximal activation and display greater awareness to BPTES inhibition. In comparison, the K320A mutation leads to a glutaminase that displays near maximal activity in the lack of phosphate and isn’t inhibited by BPTES. Hence, lysine N-acetylation may donate to the severe legislation of glutaminase activity in a variety of tissue and alter the efficiency of BPTES-type inhibitors. gene is normally its powerful activation by phosphate and various other polyvalent anions (Curthoys et al., 1976). The Kilometres for glutamine reduces in the current presence of raising phosphate focus and phosphate activation correlates using the association of inactive dimers to create energetic tetramers (Godfrey et al., 1977; Morehouse and Curthoys, 1981) and bigger oligomers (Ferreira et al., 2013). BPTES, bis-2[5-phenylacetamido-1,2,4-thiadiazol-2-yl]ethylsulfide, features as an extremely specific and powerful uncompetitive inhibitor (KI of 0.2 M) regarding glutamine (Hartwick and Curthoys, 2011). BPTES blocks the allosteric activation due to phosphate binding, promotes the forming of an inactive tetramer, and prevents the forming of bigger phosphate-induced oligomers (Robinson et al., 2007). As a result, BPTES is normally a powerful inhibitor of the isoform of glutaminase that binds for an allosteric site and prevents a conformational transformation that’s needed is for activity. The gene includes 19 exons and uses choice splicing and various NVP-BKM120 Hydrochloride manufacture polyadenylation sites to create multiple mRNAs (Porter et al., 2002). The kidney-type glutaminase (KGA) mRNA (Shapiro et al., 1991) comes from exons NVP-BKM120 Hydrochloride manufacture 1C14 and 16C19 and it is terminated at choice polyadenylation signals to make a NVP-BKM120 Hydrochloride manufacture even more abundant 4.7-kb and a less abundant 3.4-kb mRNA that encode the same 74-kDa precursor (Fig. 1). The initial 16 proteins from the KGA series form an amphipathic -helix that features being a mitochondrial concentrating on series (Shapiro et al., 1991). Pursuing translocation into mitochondria, the matrix digesting protease creates the mature 66-kDa subunit by removal of the N-terminal 72-amino acids (Srinivasan et al., 1995). A variant from the KGA cDNA, termed GAC, was cloned from a individual carcinoma cDNA collection (Elgadi et al., 1999). The GAC mRNA comes from exons 1C15 possesses a distinctive C-terminal coding series and 3-UTR. The shorter GAC precursor proteins NVP-BKM120 Hydrochloride manufacture can be translocated in to the mitochondria and likewise processed to make a 58-kDa subunit. The central primary area of either gene item forms an extremely conserved structure that’s characteristic of most crystallized types of glutaminase (Dark brown et al., 2008; Cassago et al., 2012; DeLaBarre et al., 2011; Thangavelu et al., 2012). Open up in another screen Fig. 1 Buildings from the individual gene as well as the hKGA and hGAC isoforms of individual glutaminase. The hgene encodes 19 exons that are additionally spliced to encode both isoforms which contain exclusive C-termini. The original precursors of both hKGA and hGAC are cleaved at two sites (arrows) with the matrix digesting protease pursuing translocation in to the mitochondria. The 1 constructs absence the series encoded by exon 1. The framework of individual NVP-BKM120 Hydrochloride manufacture glutaminase (hGAC71C598) sure to BPTES was lately driven (DeLaBarre et al., 2011). The hGAC forms an extremely symmetrical tetramer filled with two substances of BPTES that sit on the dimer:dimer interfaces (PDB:3UO9). The N-terminal area (residues 71C135) includes an amino series Rabbit Polyclonal to EFEMP2 of low intricacy. This area and the initial C-terminal portion (residues 547C598) aren’t noticeable in the X-ray crystallographic framework, suggesting they are extremely versatile or disordered. Residues 137C224 type little helical domains of unidentified function that sit on the edges from the tetramer contrary in the dimer:dimer interfaces. The catalytic primary from the hGAC (residues 224C546) forms a concise globular structure that’s made up of two domains. One domains is completely -helical as well as the various other includes both -helices and -bed sheets. Both domains type a pocket, which provides the energetic site serine residue. A co-crystallized glutamate molecule was firmly destined within this grove and properly positioned next to the.", "domain": "chemistry", "round": 3} +{"url": "https://www.mobil.ca/en-ca/lubricants/industrial/lubricant-expertise/resources/mobil-pegasus-1005-helps-gas-compression-plant", "date": "2023-03-23T21:35:00Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-14/segments/1679296945183.40/warc/CC-MAIN-20230323194025-20230323224025-00724.warc.gz", "language_score": 0.8819094300270081, "token_count": 448, "dump": "CC-MAIN-2023-14", "global_id": "webtext-fineweb__CC-MAIN-2023-14__0__61639823", "lang": "en", "text": "Mobil Pegasus™ 1005 helps gas compression plant\nCAT 3612 Gas Engines\nGas Compression Plant\nTartagal, Salta, Argentina\nAn Argentinian gas compression plant that operates a fleet of six CAT™ 3612 engines maintained oil drain intervals of 5,000 hours with a previous lubricant. Maintenance personnel were pleased with engine performance, and a borescope inspection found that the engine components were in good condition. Plant managers approached Mobil engineers to determine ways to further extend oil drain intervals and enhance engine performance.\nMobil engineers recommended transitioning the six engines to Mobil Pegasus™ 1005, a natural gas engine oil formulated with premium base stocks and advanced additive technology, and designed to provide the highest level of protection while maintaining exceptional engine performance. Engineers also recommended implementing routine Mobil ServSM Lubricant Analysis and borescope inspections to monitor the condition of engine components and the in-service lubricant.\nAfter transitioning to Mobil Pegasus 1005 natural gas engine oil, maintenance personnel successfully doubled oil drain intervals from 5,000 hours to 10,000 hours. Mobil Serv Lubricant Analysis also revealed diminished levels of oxidation and nitration, while borescope inspections confirmed there were no deposits of varnish, lacquer or carbon residue on the various engine components. The extended oil drain intervals and reduced oil consumption generated an annual savings of US $53,700.\nThe product performance of Mobil Pegasus 1005, alongside the application expertise provided by local Mobil engineering support and Mobil Serv Lubricant Analysis, is helping to improve customer productivity potential.\n*This success story is based on the experience of a single customer. Actual results can vary depending upon the type of equipment used and its maintenance, operating conditions and environment, and any prior lubricant used.\n*ExxonMobil shall include Exxon Mobil alliance partners.\nNatural gas engines\nThe right industrial lubricants can improve natural gas engine reliability and performance. Learn how Mobil™ industrial lubricants are helping the natural gas engine industry achieve higher levels of productivity.\nMobil Pegasus™ 1005 reduces oil consumption\nMobil Pegasus™ 1005 helps an oil and natural gas exploration company generate annual savings by extending oil drain intervals.", "domain": "chemistry", "round": 3} +{"url": "http://lkerusa.com/water-problem-hard-water/", "date": "2019-02-23T16:52:30Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-09/segments/1550249508792.98/warc/CC-MAIN-20190223162938-20190223184938-00192.warc.gz", "language_score": 0.9634727239608765, "token_count": 369, "dump": "CC-MAIN-2019-09", "global_id": "webtext-fineweb__CC-MAIN-2019-09__0__8023178", "lang": "en", "text": "Water is the most basic requirement for living beings for better survival as water can be used in washing, drinking, bathing and for other personal use also. The thing which have to be keep in mind that there is a great difference in Soft and Hard water. Soft water can be used in all type of work with no worries.\nThe water in which extra calcium and magnesium is present is considered as Hard water. This Hard water cannot be used for personal use. This type of water is created when the water passes from the passage where there is formation of rocks and it takes extra calcium and magnesium. The hard water is not difficult to differentiate from soft water. Due to the extra magnesium and calcium present in hard water, there is formation of scum when it is added to soap. This scum creates lots of problems as it collects on shower walls, clogs the pores of skin, clings to hair and cleaning the house from this water is that’s why so uneasy. Hard water can also give us head ache of damage pipes, and water heaters will also not work properly and that’s why water softener appliances is must be use to remove headache of hard water.\nAppliances or Systems for Water Softener\nNelson Water Company provides many machines which helps to remove hardness of water with ease and meaningful manner. The following are the two best water softener appliances which is very common among customers of Nelson Water.\nThis is designed especially for city water as it will soften, clean and filter the water for you. This appliance is to understand and smart looking also.\nThis is twin of ERR 3700 but it comes with extra facility of Electronic Timer Controllers and it also sends alerts, if you are using water in excessive.\nAll above appliances have different features and very stylish also.", "domain": "chemistry", "round": 3} +{"url": "https://journals.ut.ac.ir/article_77128.html", "date": "2023-01-27T15:25:41Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-06/segments/1674764494986.94/warc/CC-MAIN-20230127132641-20230127162641-00194.warc.gz", "language_score": 0.6719917058944702, "token_count": 4033, "dump": "CC-MAIN-2023-06", "global_id": "webtext-fineweb__CC-MAIN-2023-06__0__2742955", "lang": "en", "text": "|تعداد مشاهده مقاله||103,276,312|\n|تعداد دریافت فایل اصل مقاله||81,338,852|\nPhytochemical and Quality Attributes of Strawberry Fruit under Osmotic Stress of Nutrient Solution and Foliar Application of Putrescine and Salicylic Acid\n|International Journal of Horticultural Science and Technology|\n|دوره 7، شماره 3، آذر 2020، صفحه 263-278 اصل مقاله (670.42 K)|\n|نوع مقاله: Research paper|\n|شناسه دیجیتال (DOI): 10.22059/ijhst.2020.298283.347|\n|Masoud Haghshenas1؛ Mohammad Javad Nazarideljou 2؛ Akbar Shokoohian1|\n|1Department of Horticulture, Faculty of Agriculture, University of Mohaghegh Ardabili, Ardabil, Iran|\n|2Department of Horticultural Sciences, Faculty of Agriculture, Mahabad Branch, Islamic Azad University, Mahabad, Iran|\n|The moderating role of salicylic acid (SA) and putrescine (PUS) as plant growth regulators (PGRs), on the growth parameters and phytochemical and qualitative characteristics of strawberry fruit 'Selva' under osmotic stress was investigated under soilless culture. The osmotic potential (salinity) of the nutrient solution containing different NaCl concentrations (0, 7.5, 15, 30 and 45 mM) and foliar application of PUS (0 and 1.5 mM) and SA (0 and 1.5 mM) were studied. The results showed a significant decrease in plant leaf area (79.6%), total chlorophyll content (48%), fruit yield (73.5%), leaf relative water content (33%), total protein (33.4%), total phenol (7.8%), and vitamin C content (24.5%) under osmotic stress. Moreover, peroxidase (POD) and superoxide dismutase (SOD) enzymes activity, leaf ion leakage, and soluble carbohydrate and proline content increased significantly under osmotic stress. Application of PGRs had a significant effect on all the studied traits (except for SOD activity). Interactive effects of salinity and PGRs were significant on all the traits except for leaf ion leakage, POD activity, soluble carbohydrates, and protein. The highest total phenol and vitamin C contents were obtained with 15 mM salinity along with foliar application of PGRs. In conclusion, foliar application of PUS and SA ameliorate negative effects of salt stress on growth, yield, and quality of strawberry fruit.|\n|Antioxidant؛ salinity؛ yield؛ soilless culture|\n10. Dhindsa R.S, Plumb-Dhindsa, P, Thorpe T.A. 1981. Leaf senescence: correlated with increased levels of membrane permeability and lipid peroxidation, and decreased levels of superoxide dismutase and catalase. Journal of Experimental botany 32(1), 93-101.\n11. Dong J, Wan G, Liang Z. 2010. Accumulation of salicylic acid-induced phenolic compounds and raised activities of secondary metabolic and antioxidative enzyme in Salvia miltiorrhiza cell culture. JournalBiotechnol 148(2-3), 99-104.\n12. Duan J, Li J, Guo Sh, Kang Y. 2008. Exogenous spermidine affects polyamine metabolism in salinity-stressed Cucumis sativus roots and enhances short-term salinity tolerance. Journal of Plant Physiology 165, 1620- 1635.\n13. Eshghi S, Moharami S, Jamali B. 2017. Effect of salicylic acid on growth, yield and fruit quality of strawberry cv. ‘Paros’ under salinity conditions. Journal of Science and Technology of Greenhouse Culture 7(4), 163-174.\n14. Farkhondeh R, Nabizadeh E, Jalilnezhad N. 2012. Effect of salinity stress on proline content, membrane stability and water relations in two sugar beet cultivars. International Journal of AgriScience 2, 385-392.\n15. Ghaderi N, Normohammadi S, Javadi T. 2015. Morpho-physiological Responses of Strawberry (Fragaria×ananassa) to Exogenous Salicylic Acid Application under Drought Stress. Journal Agriculture Science and Technology 17, 167-178.\n16. Giampieri F, Tulipani S, Alvarez-Suarez J.M, Quiles J.L, Mezzetti B, Battino M. 2012. The strawberry: Composition, nutritional quality, and impact on human health. Nutrition 28, 9-19.\n17. Groppa M.D, Benavides M.P. 2008. Polyamines and abiotic stress: recent advance. Amino Acids 34, 35-45.\n18. Hayat Q, Hayat S, Irfan M, Ahmad A. 2010. Effect of exogenous salicylic acid under changing environment. Environmental and Experimental Botany 68, 14-25.\n19. Hernandez-Munoz P, Almenar E, Del-Valle V, Velez D, Gavara R. 2008. Effect of Chitosan Coating Combined with Postharvest Calcium Treatment on Strawberry (Fragaria× Ananassa) Quality During Refrigerated Storage. Food Chemistry 110 (2), 428–435.\n20. Huang Z, Zhao L, Chen D, Liang M, Liu Z, Shao H, Long X. 2013. Salt stress encourages proline accumulation by regulating proline biosynthesis and degradation in Jerusalem Artichoke Plantlets. PLoS One 8(4), e62085.\n21. Hussain S.S, Ali M, Ahmad M, Siddique K.H. 2011. Polyamines: natural and engineered abiotic and biotic stress tolerance in plants. Biotechnology Advances 29, 300–311.\n22. Jamali B, Eshghi S, Tafazoli E. 2013. Vegetative growth, yield, fruit quality and fruit and leaf composition of strwberry cv. ‘Pajaro’ as influenced by salicylic acid and nickel sprays. Journal of Plant Nutrition 36, 1043-1055.\n23. Jamalian S, Tehranifar A, Tafazoli E, Eshghi S, Davarynejad Gh.H. 2008. Paclobutrazol application ameliorates the negative effect of salt stress on reproductive growth, yield, and fruit quality of strawberry plants. Horticulture Environment and Biotechnology 49(4), 1-6.\n24. Javaheri M, Mashayekhi K, Dadkhah A, Zaker Tavallaee F. 2012. Effects of salicylic acid on yield and quality characters of tomato fruit (Lycopersicum esculentum Mill.). International journal of agriculture and crop sciences4(16), 1184-1187.\n25. Jiang C, Zu C, Lu D, Zheng Q, Shen J, Wang H. 2017. Effect of exogenous selenium supply on photosynthesis, Na+ accumulation and antioxidative capacity of maize (Zea mays L.) under salinity stress. Scientific Reports 7, 42039.\n26. Karlidag H, Yildirim E, Turan M. 2009. Salicylic acid ameliorates the adverse effect of salt stress on strawberry. Scientia Agricola 66(2), 180-187.\n27. Lee S, Kim S.G, Park C.M. 2010. 'Salicylic acid promotes seed germination under high salinity by modulating antioxidant activity in Arabidopsis'. New Phytologist 188, 626-637.\n28. Liu J.H, Nada K, Honda C, Kitashiba H, Wen X.P, Pang X.M, Moriguchi T. 2006. Polyamine biosynthesis of apple callus under salt stress: Importance of arginine decarboxylase pathway in stress response. Journal of Experimental Botany57, 2589-2599.\n29. Liu J.H, Peng T, Dai W.S. 2014. Critical cis-acting elements and interacting transcription factors: key players associated with abiotic stress responses in plants. Plant Molecular Biology 32, 303–317.\n30. Ma X, Zheng J, Zhang X, Hu Q, Qian R. 2017. 'Salicylic acid alleviates the adverse effects of salt stress on Dianthus superbus (Caryophyllaceae) by activating photosynthesis, protecting morphological structure, and enhancing the antioxidant system'. Frontiers in Plant Science. 8, 600.\n31. Mahajan Sh, Tuteja N. 2005. Cold, salinity and drought stresses: An overview. Archives of Biochemistry and Biophysics. 444, 139-158.\n32. Mahgoub M.H, Abd-El Aziz N.G, Mazhar A.M.A. 2011. Response of Dahlia pinnata L. plant to foliar spray with Putrescine and thimine on growth, flowering and photosynthetic. American-Eurasian Journal of Agricultural and Environmental Sciences 10 (5), 769-775.\n33. Menendez A.B, Rodriguez A.A, Maiale S.J, Rodriguez-Kessler M, Jimenez-Bremont J.F, Ruiz O.A. 2012. Polyamines contribution to the improvement of crop plants tolerance to abiotic stress. In: Tuteja, N. and Gill, S.S. (eds). Crop improvement under adverse conditions. Springer, Morlenbach, Germany, pp. 113–137.\n34. Mishra P.K, Siddiqui M.W, Sahay S. 2016. Polyamines. In postharvest management approaches for maintaining quality of fresh produce. Springer International Publishing AG, pp. 69-96.\n35. Mishra S, Srivastava S, Tripathi P.D. 2006. Phytochelatin synthesis and response of antioxidants during cadmium stress in Baccopa monnieri L. Journal Plant Physiology and Biochemistry 44, 25-31.\n36. Miura K, Tada Y. 2014. 'Regulation of water, salinity, and cold stress responses by salicylic acid'. Frontiers in Plant Science 5, 4.\n38. Omaye S.T, Turnbull J.D, Sauberlich, H.E. 1979. Selected methods for the determination of ascorbic acid in animal cells, tissues, and fluids. In Methods in enzymology (Vol. 62, pp. 3-11). Academic press.\n39. Palha M.G, Campo J.L, Oliveira P.B. 2010. Optimizing a high-density soilless culture system for strawberry production. In XXVIII International Horticultural Congress on Science and Horticulture for People (IHC2010): International Symposium on 926, 503-507.\n40. Parida A.K, Das A.B. 2005. Salt tolerance and salinity effect on plants: a review. Ecotoxicology and Environmental Safety 60, 324–349.\n41. Parvaiz A, Satyawati S. 2008. Salt stress and phyto-biochemical responses of plants. Plant, Soil and Environment 54, 89-99.\n42. Pattanagule W, Thitisakakul M. 2008. Effect of salinity stress on growth and carbohydrate metabolism in three rice (Oryza sativa L.) cultivars differing in salinity tolerance. Indian Journal of Experimental Biology46, 736-742.\n43. Pedraza R.O, Motok J, Tortora M.L, Salazar S.M, Díaz-Ricci J.C. 2007. Natural occurrence of Azospirillum brasilense in strawberry plants. Plant and Soil 295, 169-78.\n44. Ritchie SW, Nguyen H.T, Scott Holaday, A. 1990. Leaf water content and gas-exchange parameters of two wheat genotypes differing in drought resistance. Crop Science 30(1), 105-111.\n45. Roustakhiz J, Saboki E. 2017. Effect of salicylic acid on yield and yield component of grapevine (Vitis vinifera) under salinity stress condition. International Journal of Farming and Allied Sciences 6 (1), 39-42.\n46. Sai Kachout S, Ben Mansoura A, Jaffel Hamza K, Leclerc J.C, Rejeb M.N, Ouerghi N. 2011. Leaf–water relations and ion concentrations of the halophyte Atriplex hortensis in response to salinity and water stress. Acta Physiologiae Plantarum 33(2), 335-342.\n47. Saied A.S, Keutgen A.J, Noga G. 2005. The influence of NaCl salinity on growth, yield, and fruit quality of strawberry cvs. ‘Elsanta’ and’Korona’. Sciences Horticulture. 103, 289-303.\n48. Samadi S, Habibi G, Vaziri A. 2019. 'Effects of exogenous salicylic acid on antioxidative responses, phenolic metabolism and photochemical activity of strawberry under salt stress'. Iranian Journal of Plant Physiology9 (2), 2685- 2694.\n49. Shahmoradi H, and Naderi D. 2018. Improving effects of salicylic acid on morphological, physiological and biochemical responses of salt-imposed winter jasmine. International Journal of Horticultural Science and Technology, 5(2), 219-230.\n50. Shen C, Hu Y, Du X, Li T, Tang H, Wu J. 2014. 'Salicylic acid induces physiological and biochemical changes in Torreya grandis cv. Merrillii seedlings under drought stress'. Trees 28, 961-970.\n51. Shirko R, Nazarideljou M.J, Akbar M.A, Naser G. 2018. Photosynthetic reaction, mineral uptake, and fruit quality of strawberry affected by different levels of macronutrients. Journal of Plant Nutrition 41(14), pp.1807-1820.\n52. Stevens J, Senaratna T, Sivasithamparam K. 2006. Salicylic acid induces salinity tolerance in tomato (Lycopersicon esculentum cv. Roma): associated changes in gas exchange, water relations and membrane stabilization. Plant Growth Regulation 49, 77-83.\n53. Sun C, Fu D, Jin L, Chen M, Zheng X, Yu T. 2018. Chitin isolated from yeast cell wall induces the resistance of tomato fruit to Botrytis cinerea. Carbohydrate polymers 199, 341-352.\n54. Syed Sarfraz H, Muhammad A, Maqbool A, Kadambot H.M. 2011. Polyamines: Natural and engineered abiotic and biotic stress tolerance in plants. Biotechnology Advances 29, 300-311.\n55. Tang W, Newton J.R. 2005. Polyamines reduced salt induced oxidative damage by increasing the activities of antioxidant enzymes and decreasing lipid peroxidation in Virginia pine. Plant Growth Regulation 46, 31-43.\n56. Unal D, Tuney I, Sukatar A. 2007. The role of external polyamines on photosynthetic responses, lipid peroxidation, protein and chlorophyll a content under the UV-A (352 nm) stress in Physica semipinnata. Journal Photochem Phytobiol 90, 64-68.\n57. Verma S, Mishra S.N. 2005. Putrescine alleviation of growth in salt stressed Brassica Juncea by inducing antioxidative defense system. Journal of Plant Physiology, 162, 669-677.\n58. Warrence N, Pearson, K.E, Bavder J.W. 2002. The basic of salinity and sodicity effect on soil physical properties. Journal of Plant Physiology 25, 64-70.\n59. Xu Z, Rothstein S.J. 2018. ROS-Induced anthocyanin production provides feedback protection by scavenging ROS and maintaining photosynthetic capacity in Arabidopsis. Plant Signaling and Behavior 13, 1364-1377.\n60. Yildirim E, Turan M, Guvenc I. 2008. Effect of foliar salicylic acid applications on growth, chlorophyll and mineral content of cucumber grown under salt stress. Journal Plant Nutrition 31, 593-612.\n61. Zahedi S.M, Hosseini M.S, Abadía J, Marjani M. 2020. Melatonin foliar sprays elicit salinity stress tolerance and enhance fruit yield and quality in strawberry (Fragaria× ananassa Duch.). Plant Physiology and Biochemistry 149, 313-323.\n62. Zhang RH, Li J, Guo SR, Tezuka T. 2009. Effects of exogenous putrescine on gasexchange characteristics and chlorophyll fluorescence of NaCl-stressed cucumber seedlings. Photosynthesis Research 100, 155-162.\n63. Zhao Y, Jiao K, Herbert S.J, Hao L. 2008. Salicylic acid, hydrogen peroxide and calcium-induced saline tolerance associated with endogenous hydrogen peroxide homeostasis in naked oat seedlings. Journal Plant Growth Regul 54, 249-259.\nتعداد مشاهده مقاله: 404\nتعداد دریافت فایل اصل مقاله: 517", "domain": "chemistry", "round": 3} +{"url": "http://link.springer.com/article/10.1007%2Fs00018-005-5554-9", "date": "2017-04-29T01:00:20Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-17/segments/1492917123102.83/warc/CC-MAIN-20170423031203-00214-ip-10-145-167-34.ec2.internal.warc.gz", "language_score": 0.8784094452857971, "token_count": 336, "dump": "CC-MAIN-2017-17", "global_id": "webtext-fineweb__CC-MAIN-2017-17__0__115161658", "lang": "en", "text": "P-glycoprotein and ‘lipid rafts’: some ambiguous mutual relationships (floating on them, building them or meeting them by chance?)\n- First Online:\n- Cite this article as:\n- Orlowski, S., Martin, S. & Escargueil, A. Cell. Mol. Life Sci. (2006) 63: 1038. doi:10.1007/s00018-005-5554-9\n- 297 Downloads\nP-glycoprotein (P-gp) is an active membrane transporter responsible for cell detoxification against numerous amphiphilic compounds, leading to multidrug resistance in tumor cells. It displays entangled connections with its membrane environment since it recognizes its substrates within the cytosolic leaflet and it also translocates some endogenous lipids to the exoplasmic leaflet. Regarding its relationships with membrane microdomains, ‘lipid rafts’, a literature analysis concludes that (i) P-gp also exists in rafts and non-raft membrane domains, depending on the cell considered, the experimental conditions and the method used to test it; (ii) cholesterol has a positive influence on P-gp function, and this may be a direct effect of the free cholesterol present in membrane or an indirect effect mediated by the cholesterol-enriched microdomains; (iii) when present in rafts, P-gp interacts with protein partners regulating its activity; (iv) P-gp is a lipid translocase that handles the raft-constituting lipids with particular efficiency, and it also influences membrane trafficking in the cell.", "domain": "chemistry", "round": 3} +{"url": "http://vivo.med.cornell.edu/display/pubid0027162553", "date": "2019-11-14T11:05:29Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-47/segments/1573496668416.11/warc/CC-MAIN-20191114104329-20191114132329-00233.warc.gz", "language_score": 0.9001162052154541, "token_count": 375, "dump": "CC-MAIN-2019-47", "global_id": "webtext-fineweb__CC-MAIN-2019-47__0__12309829", "lang": "en", "text": "Sphingomyelinase and ceramide activate mitogen-activated protein kinase in myeloid HL-60 cells\nMechanisms involved in tumor necrosis factor (TNF)-alpha signal transduction are incompletely understood. In some circumstances, TNF may use a signal transduction pathway involving hydrolysis of sphingomyelin to ceramide and stimulation of a ceramide-activated protein kinase. In HL-60 cells, TNF rapidly activates this pathway and induces monocytic differentiation. Here, we demonstrate that treatment of HL-60 cells with TNF selectively increases tyrosine phosphorylation of p42 mitogen-activated protein kinase (p42mapk) and stimulates its enzymatic activity. Induction of p42mapk phosphorylation was time- and dose-dependent and closely paralleled activation of sphingomyelin hydrolysis. Direct engagement of the sphingomyelin signal transduction pathway by addition of bacterial sphingomyelinase led to MAP kinase activation. The time course of p42mapk phosphorylation in the sphingomyelinase-treated cells was similar to that of TNF, with maximal response occurring at 5 min. A maximal concentration of sphingomyelinase (0.01 unit/ml) was more potent than TNF at inducing MAP kinase enzymatic activity (2.6-fold) and phosphorylation of MAP kinase and tyrosine. The cell-permeable ceramide analogs, C2- and C6-ceramide, which mimic effects of TNF, also induced p42mapk phosphorylation within seconds. These studies indicate that the sphingomyelin pathway can regulate MAP kinase activity and suggest that MAP kinase activation by this mechanism may be involved in TNF-induced signal transduction.", "domain": "chemistry", "round": 3} +{"url": "https://www.guiadeblogs.com/get-lightest-deep-cycle-battery-for-your-appliances/", "date": "2022-10-04T22:29:48Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-40/segments/1664030337529.69/warc/CC-MAIN-20221004215917-20221005005917-00078.warc.gz", "language_score": 0.9514563679695129, "token_count": 1277, "dump": "CC-MAIN-2022-40", "global_id": "webtext-fineweb__CC-MAIN-2022-40__0__166556692", "lang": "en", "text": "The lightest deep cycle battery is used to power all kinds of small boats and other watercraft. They have a longer lifespan than standard automotive batteries and can be recharged many times without losing their ability to hold a charge. Lithium deep cycle marine batteries also have some unique advantages that make them ideal for this application, but they cost more than conventional lead acid batteries.\nHigh discharge rate\nA high discharge rate means the battery can be used for high-power applications.\nIt’s important for electric vehicles, solar power, and boats.\nIt can also be used to power small appliances such as microwaves, fans, or lights. The battery’s high capacity means that it’s possible to use more energy than an average home might require on its own.\nThe high discharge rate of Lithium under bonnet battery means that it is well suited to power boats and other vehicles since they have higher electricity demands than expected in a typical residential home. The capacity of this type makes it easy to charge multiple devices from one source, so users don’t need many individual batteries.\nThe battery’s high capacity means that it’s possible to use more energy than an average home might require on its own. The high discharge rate of lithium 100ah deep cycle marine battery means that it is well suited to power boats and other vehicles since they have higher electricity demands than expected in a typical residential home. The capacity of this type makes it easy to charge multiple devices from one source, so users don’t need many individual batteries.\nLong shelf life\nLithium batteries offer a long shelf life. They can be stored for years without losing their charge. It means you won’t have to worry about your lithium battery losing its power if you don’t use it for a long time, like during the winter.\nHowever, lithium batteries should not be used for short-term use, or they will fail prematurely. The reason behind this is that when lithium batteries are constantly drained and recharged (more than once every 1-2 weeks), the battery may become damaged or even catch fire!\nIt can be recharged many times\nThe rechargeable deep cycle battery ah can be recharged over and over again. LiFePO4 batteries have a very long life span, up to 10 years of service life in applications that require frequent cycling. The lithium-ion battery is also highly resistant to elevated temperatures, so it will not malfunction even when it rises above 65 degrees Celsius.\nBecause it has a high discharge rate, you do not need much time to recharge them after using them during your trip or daily activities. It only takes 2-3 hours to get back their full charge after draining out all of its energy being utilized by your devices such as mobile phones or laptops before going on a boat trip with your friends! Because its discharge rate is higher than other types of batteries available today (i.e., lead acid), this type of battery is more commonly used nowadays due, especially because they’re lighter compared with lead-acid ones, which tend toward heavier weights when fully charged up initially.”\nThe best way to ensure that your 100ah deep cycle marine battery lasts as long as possible is to keep it plugged in at all times. If you are going on vacation or leaving your vehicle idle for more than a week, make sure that there is always power flowing through its terminals by using an inverter or other external energy source like solar panels.\nCan withstand severe conditions\nLithium-ion batteries can be used in various applications, including vehicles and transportation. Lithium-ion batteries are relatively new to the world of cars. Still, they have become popular in recent years as an alternative to lead-acid and other types of deep cycle batteries. These batteries are lightweight, compact and long lasting, making them well suited for marine applications.\nAlthough lithium-ion batteries can withstand many different conditions, there are some situations where they may not perform optimally or may not be suitable for use. For example:\nLithium-ion batteries are particularly affected by high temperatures. Lithium-ion batteries have a high operating temperature range of between 50°C and -20°CSecondly, it’s essential that these batteries can withstand all kinds of severe conditions while your devices are utilizing them. The lithium-ion battery is resistant to hot temperatures, so even when you go on a trip and the temperature rises above 65 degrees Celsius, these batteries won’t malfunction in any way. And because they have such high discharge rates, only 2-3 hours will be needed for them to get back their full charge after draining out all of their energy by using.\nLithium deep cycle marine batteries have plenty of advantages over other batteries, but you will also pay more.\nThere are a few reasons that lithium batteries are more expensive than other types of deep cycle marine batteries. First, the raw materials used to make them are more expensive than lead and other metals used in standard deep cycle marine batteries. Second, the manufacturing process is more complicated and time-consuming than standard deep cycle marine battery manufacturing processes.\nThird, they have a shorter lifespan in most applications (1-3 years versus 5-10 years). Lastly, they’re smaller and lighter than other deep-cycle marine batteries, making them easier to carry if you need to move your boat or RV around.\nDespite their high cost, deep lithium cycle marine batteries have several advantages over other types of batteries. They’re lighter and smaller than other batteries, so you can fit more of them into the same space. They also last longer than other types, which means less maintenance.\nLithium deep cycle marine batteries are the best but have a very high price tag.\nBattery technology continues to advance, and deep lithium cycle marine batteries have made huge strides in recent years. They are still expensive but offer many benefits for people who need a battery that can withstand harsh conditions or be recharged many times before it needs replacement. Lithium batteries are worth considering over other types of batteries as long as you have the budget. Looking for a 100ah marine deep cycle battery? If yes, contact Deep Cycle Systems for a high-quality battery at an affordable price.", "domain": "chemistry", "round": 3} +{"url": "https://www.support-oil.com/en/acea-quality-classification", "date": "2024-04-22T21:26:42Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712296818374.84/warc/CC-MAIN-20240422211055-20240423001055-00740.warc.gz", "language_score": 0.8721786737442017, "token_count": 310, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__118421403", "lang": "en", "text": "ACEA (Association of Constructeurs Europeens de l'Automobile) means European Motor Manufacturers Association. It prepares specifications for engine oils covering the most stringent and demanding European test materials.\nACEA specifications represent the largest common denominator of data from engine oils of European vehicle and engine equipment.\nACEA specifications are divided into sections A, B, C and E. The E tank is only valid for trucks. The expiration numbers of sequence documents are making them more distinctive.\nACEA Sequence A - Contains standard requirements for gasoline engines of passenger cars.\nACEA Sequence B - Contains standard requirements for diesel engines of passenger cars, pickup trucks and light commercial vehicles.\nACEA Sequence C – In vehicles with diesel engine oil for exhaust emission limitation, it is necessary to use engine oils of the appropriate size to prevent clogging of the diesel media filters. The final results for the formation of ash are the presence of sulfated ash, sulfur and phosphorus in the engine oil in the allowable proportions, taking the feature of low ash (LOW SAPS) engine oil and sifting it according to the ACEA C specification.\nACEA Sequence E – Contains standard requirements for diesel engines used in trucks. Engine oils for automobiles always indicate a combined life of diesel and gasoline engines. (eg ACEA A3 / B3). The numbers following the letters define the differences between engine oils. The higher the number, the higher the engine oil meets the higher requirements.", "domain": "chemistry", "round": 3} +{"url": "https://www.omicsonline.org/references/downregulation-of-cholesterol-7alphahydroxylase-cyp7a1-gene-expression-by-bile-acids-in-primary-rat-hepatocytes-is-mediated-by-the-cjun-nterminal-kinase-pathway-130478.html", "date": "2017-11-21T16:44:44Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-47/segments/1510934806419.21/warc/CC-MAIN-20171121151133-20171121171133-00413.warc.gz", "language_score": 0.885775625705719, "token_count": 421, "dump": "CC-MAIN-2017-47", "global_id": "webtext-fineweb__CC-MAIN-2017-47__0__211474274", "lang": "en", "text": "Author(s): Gupta S, Stravitz RT, Dent P, Hylemon PB\nAbstract Share this page\nAbstract Cholesterol 7alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in the neutral pathway of bile acid biosynthesis, is feedback-inhibited at the transcriptional level by hydrophobic bile acids. Recent studies show that bile acids are physiological ligands for farnesoid X receptor (FXR). Activated FXR indirectly represses CYP7A1 transcription through induction of small heterodimer protein (SHP-1). In this study, we provide evidence that bile acids rapidly down-regulate CYP7A1 transcription via activation of the JNK/c-Jun pathway. Furthermore, we demonstrate that SHP-1 is also a direct target of activated c-Jun. In primary rat hepatocyte cultures, taurocholate (TCA) strongly activated JNK in a time- and concentration-dependent manner. Tumor necrosis factor-alpha, a potent activator of JNK, also rapidly activated JNK and down-regulated CYP7A1 mRNA levels. Overexpression of dominant-negative JNK1 or a transactivating domain mutant of c-Jun significantly blocked the ability of TCA to down-regulate CYP7A1 mRNA. In contrast, overexpression of wild-type c-Jun (c-Jun(wt)) enhanced the repression of CYP7A1 by TCA. Moreover, overexpression of c-Jun(wt) resulted in increased SHP-1 promoter activity. Mutation of a putative AP-1 (c-Jun) element suppressed c-Jun-mediated activation of the SHP-1 promoter construct. These results indicate that the bile acid-activated JNK pathway plays a pivotal role in regulating CYP7A1 levels in primary rat hepatocytes.\nThis article was published in J Biol Chem\nand referenced in Endocrinology & Metabolic Syndrome", "domain": "chemistry", "round": 3} +{"url": "https://cohaitungchi.com/challenges-and-opportunities-in-the-management-of-onychomycosis", "date": "2023-03-21T10:48:11Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-14/segments/1679296943695.23/warc/CC-MAIN-20230321095704-20230321125704-00782.warc.gz", "language_score": 0.9167984127998352, "token_count": 804, "dump": "CC-MAIN-2023-14", "global_id": "webtext-fineweb__CC-MAIN-2023-14__0__131455414", "lang": "en", "text": "4. Natural Therapies\nGiven the challenges associated with available topical and systemic agents, there is a renewed interest in exploring alternative natural treatments for onychomycosis . Natural onychomycosis therapies may have some important advantages over current treatments. They have the potential to be less expensive, particularly if classified as over-the-counter or complementary medications. Furthermore, they have shown low levels of adverse reactions in human trials (mostly skin irritation or mild pain) (Table 1), suggesting that these medications could be safer and more tolerable than standard therapies. Because of the complex nature and composition of bioactive constituents present in plant-based treatments, natural treatment modalities may carry a lower risk for the development of fungal resistance . These qualities indicate potential for natural therapies to be employed as prophylactic agents against onychomycosis.\nWhile a number of natural remedies have shown promising antifungal activity in vitro, clinical trials on these treatments are as yet in early stages. For example, essential oils like tea tree oil have demonstrated antifungal activity in vitro [24,25], but their efficacy has not been adequately confirmed against onychomycosis in human trials (Table 1). Most human trials investigating natural therapies for onychomycosis have been small-scale pilot studies that are not directly comparable with trials on standard treatments due to differences in design and methodology.\nA six-month clinical trial investigated Ageratina pichinchensis (AP), a plant used in traditional Mexican medicine, as a topical treatment for onychomycosis . Results showed AP 10% lacquer to be equivalent to ciclopirox 8% lacquer in terms of effectiveness against onychomycosis , and a follow-up trial showed that higher concentrations of AP can improve patient outcomes . Natural Coniferous Resin (NCR) lacquer showed a mycological cure rate of 65% in a preliminary observational study , but only 13% in a randomised controlled trial. The clinical trial showed nine months of daily-applied NCR lacquer to be about as effective as weekly-applied amorolfine 5% lacquer, but less effective than three months of once-daily oral terbinafine (250 mg) .\nRead more 16 NexGen Nails Pros and Cons\nRecent pilot studies suggest potential for other natural compounds as therapeutic options for onychomycosis. For example, propolis, an adhesive resinous compound produced by honeybees to seal and protect their hives from pathogenic agents, exhibits significant antifungal and anti-biofilm activities in vitro . A pilot study assessing treatment of onychomycosis with topical ethanol propolis extract for six months showed complete mycological and clinical cure in 56.3% (n = 16), with no adverse events reported . The over-the-counter topical cough suppressant Vicks VapoRub® also showed some effectiveness against onychomycosis in a small-scale uncontrolled pilot study (n = 18; mycological cure rate 27.8%; partial/complete clinical cure rate 55.6%/27.8%) . This product contains a combination of active and inactive ingredients, including camphor, eucalyptus oil, menthol and thymol, that have shown in-vitro activity against dermatophytes. It has been suggested that Vicks VapoRub® may be a suitable onychomycosis treatment for people living with HIV due to its low cost, minimal side effects and compatibility with antiretroviral medications .\nFurther large well-designed randomised controlled trials are necessary to determine the efficacy of natural treatments and make formal recommendations as to their use in onychomycosis.", "domain": "chemistry", "round": 3} +{"url": "https://www.supernine.com/zh-tw/blogs/news/the-nad-downward-spiral", "date": "2022-05-24T21:48:15Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-21/segments/1652662577259.70/warc/CC-MAIN-20220524203438-20220524233438-00493.warc.gz", "language_score": 0.942866861820221, "token_count": 554, "dump": "CC-MAIN-2022-21", "global_id": "webtext-fineweb__CC-MAIN-2022-21__0__153775215", "lang": "en", "text": "The NAD+ downward spiral\nNAD+ biosynthesis, mainly mediated by NAMPT and NAD+ consumption by NAD+ consuming enzymes, are in a delicate balance so that perturbations to either side can cause significant derailment of the system. A vicious cycle may exist in which molecular mechanisms involved in the aging process, such as oxidative stress, DNA damage, senescence, and inflammation, lead to tissue NAD+ decline, which subsequently exacerbates the processes that caused its decline in the first place.\nAs NAD+ is a common substrate between PARPs and SIRT1, there is a competition between their activities. If NAMPT-mediated NAD+ biosynthesis is disturbed or if NAD+ consumption is increased because of chronic DNA damage that elicits PARP activation, the intracellular NAD+ pool is decreased, and SIRT1 activity is reduced, causing an organism’s functional decline.\nFor example, PARP is chronically activated in aging worms and mice (liver or skeletal muscle). A possible explanation for these findings is that aging is associated with an increase in chronic nuclear DNA damage, which leads to NAD+ depletion by PARP. Since the loss of SIRT1 or SIRT6 activity exacerbates DNA damage may create an autocatalytic downward spiral in the nucleus with NAD+ deficit as the nexus.\nDeleting PARP1 and PARP2 enhances SIRT1 activity, resulting in increased mitochondrial content, metabolism, and protection from diet-induced obesity. In mice lacking PARP1, there was a systemic elevation in NAD+ levels, SIRT1 activity, and metabolic benefits in these mice. Notably, PARP inhibitors boost NAD+ levels and increase SIRT1 activity to restore mitochondrial fitness and function.\nParallel findings were also reported for mice with the elimination of another NAD+-consuming enzyme, CD38, as shown previously. CD38-dependent modulation of NAD+ can alter the activity of SIRT1 and other sirtuins, as well as other NAD+-consuming enzymes, and affect cellular signaling and metabolism. These studies show clearly that PARP, CD38, and the nuclear sirtuins all compete for the same pool of NAD+, and inhibition of PARP or CD38 has the potential of activating sirtuins.\nTo close the loop, there is some evidence indicating that levels of NAMPT decline during replicative senescence of human smooth muscle cells and in peripheral tissue of old mice, such as white adipose tissue and skeletal muscle. Senescence also activates the expression of CD38 in tissue-resident macrophages, and proinflammatory signaling molecules released from senescent cells increase the activity and the expression level of CD38.", "domain": "chemistry", "round": 3} +{"url": "https://www.mdpi.com/2076-0752/2/3/111", "date": "2023-09-22T03:16:28Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233506320.28/warc/CC-MAIN-20230922002008-20230922032008-00396.warc.gz", "language_score": 0.6668339967727661, "token_count": 3509, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__275468051", "lang": "en", "text": "Lacquerware Pigment Identification with Fixed and Mobile Raman Microspectrometers: A Potential Technique to Differentiate Original/Fake Artworks\n3. Experimental Methods\n- a Japanese tray (26 × 26 cm2), accessory of a two-level table imported from Japan at the end of the 19th century, depicting flowers and leaves (Figure 1a), with seven different colors: red, rose, brown, green, yellow, black and gold. Millimeter chips were taken from the reverse black side as well as from a companion black tray with a yellow lacquered rim.\n- a non-representational artwork (30 × 39.5 cm2, 1961, Figure 1b) in the style of Ta Ty, a famous Vietnamese Painter (1922–2004), with eight different colors: red, green, light green, brown, yellow, white and gold.\n- a portrait (15 × 20 cm2) from the beginning of the 1990s (Figure 1c), depicting the heroin from the famous Kim Vân Kiều novel by Nguyễn Du (1765–1820) with red, black and gold colors.The analyzed spots are indicated in Figure 1.Figure 3 (shows the lacquer paintings studied in the Collector’s rooms with the HE785 mobile Raman set-up:\n- a Đinh Cường (1939-) artwork, depicting a woman playing violin (60 × 40 cm2) with red, black, green, blue, yellow, white and gold colors.\n- an anonymous decorative lacquerware depicting flowers.\n- a Senterra microspectrometer from Bruker Optics (Germany) equipped with a Peltier-cooled CCD matrix detector and with two laser sources (edge filtered Nd:YAG 532 nm and 785 nm diode).\n- a RFS 100 s FT-Raman microscope III, also from Bruker Optics, equipped with a 1064 nm double Nd:YAG laser.\n4.1. Lacquer Medium\n|Artifact||Color||785 nm identified||1064 nm identified|\n|Japanese tray||Red||HgS vermilion||HgS vermilion|\n|Green||Prussian blue||Prussian blue|\n|Brown||HgS vermilion||HgS vermilion|\n|Ta Ty’s lacquerware||Red||Purpurine||Purpurine|\n|White 1||Egg shell||Egg shell|\n|Kim portrait||Red||HgS vermilion||HgS vermilion|\n|Black||Carbon black||Carbon black|\n4.3. Test with the Mobile Raman Set-up\nConflict of Interest\n- I.M. Bell, R.J.H. Clark, and P.J. Gibbs. “Raman spectroscopic library of natural and synthetic pigments (pre–similar to 1850 AD).” Spectrochim. Acta Part A 53 (1997): 2159–2179. [Google Scholar] [CrossRef]\n- L. Burgio, and R.J.H. Clark. “Library of FT–Raman spectra of pigments, minerals, pigment media and varnishes, and supplement to existing library of Raman spectra of pigments with visible excitation.” Spectrochim. Acta Part A 57 (2001): 1491–1521. [Google Scholar] [CrossRef]\n- R.J.H. 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[Google Scholar]\n- “Raman Spectroscopic library. ” Available online: www.chem.ucl.ac.uk/ resources/raman/index.html (accessed on day June 2012).\n© 2013 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).\nColomban, P.; Mancini, D. Lacquerware Pigment Identification with Fixed and Mobile Raman Microspectrometers: A Potential Technique to Differentiate Original/Fake Artworks. Arts 2013, 2, 111-123. https://doi.org/10.3390/arts2030111\nColomban P, Mancini D. Lacquerware Pigment Identification with Fixed and Mobile Raman Microspectrometers: A Potential Technique to Differentiate Original/Fake Artworks. Arts. 2013; 2(3):111-123. https://doi.org/10.3390/arts2030111Chicago/Turabian Style\nColomban, Philippe, and Diana Mancini. 2013. \"Lacquerware Pigment Identification with Fixed and Mobile Raman Microspectrometers: A Potential Technique to Differentiate Original/Fake Artworks\" Arts 2, no. 3: 111-123. https://doi.org/10.3390/arts2030111", "domain": "chemistry", "round": 3} +{"url": "https://www.labanalyticaltesting.com/what-is-a-headspace-vial.html", "date": "2024-04-23T18:43:34Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712296818732.46/warc/CC-MAIN-20240423162023-20240423192023-00172.warc.gz", "language_score": 0.8704017400741577, "token_count": 1498, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__47321232", "lang": "en", "text": "What is a Headspace Vial?\nThe brief introduction of headspace vials\nHeadspace vials are one of those rare laboratory supplies that are appropriately named: headspace vials are lab vials with extra space at their top (head). Simple! They’re typically used in autosampler machines in chromatography, and for that reason are sometimes called autosampler vials or chromatography vials.\nHeadspace vials are available in two major styles: crimp top and screw thread. Crimp top vials have a metal cap that’s closed with a handheld crimper. Neat. Screw thread vials have a simple screw cap, just like that cheap wine you keep buying. Both types employ stoppers or septa between the cap and the vial, depending on the application.\nWhy choose headspace vials?\nHigh-Quality headspace vials with a beveled neck for a secure seal, uniform glass thickness for even heat distribution, and a stable, strong design for ease of use. Available with rounded or flat bottom profiles for accurate instrument compatibility. Use 20mm headspace caps and septa and seal with 20mm crimping accessories.\nWhat types of headspace vials?\nRound bottom or flat bottom\nChoosing a headspace vial with a flat (also called a square) bottom or round bottom depends on your particular instrument. Generally, round-bottomed vials are used for robotic arm autosamplers that will pick up a vial and bring it to the autosampler needle, while flat-bottomed vials are used for autosamplers that bring the needle to the vial. A round bottom vial is self-aligning when it’s returned to the vial rack by the robotic arm, while a flat-bottomed vial is slightly more stable while it’s in the rack. It is best to check your autosampler’s user manual if you are not sure.\nBeveled or flat top\nFlat-topped vials can be used with almost any headspace autosampler. Beveled top vials can be used with some autosamplers. As usual, the best way to be sure which to choose is to check your autosampler’s manual. A quick guideline is that autosamplers that don’t move the vial out of the rack can use beveled top vials. Robotic arm autosamplers that use a magnetic pick-up must use flat-top vials (to give adequate contact between the magnet and the cap). Other robotic arm autosamplers may or may not be able to use beveled top vials, depending on how they grip the vial. Beveled top vials can improve the seal formed by the crimp top. In a flat-topped vial, the sealing pressure is primarily at the outer rim of the vial, cap, and septum. With a beveled top vial, the sealing pressure is evenly distributed across the top of the vial, improving the seal.\nScrew caps for headspace vials are a recent development, originally intended for magnetic robotic arm autosamplers. They sidestep the problem of crimping on an all-steel cap or a composite steel/aluminum cap. The plated steel caps are reusable and do not require tools to seal or open vials. They have some drawbacks too. They can only be used for 10mL and 20mL vials. Too much of the internal volume of a 6mL vial is lost to the threaded neck for the cap. Screw cap headspace vials are not suitable for use with mechanical robotic arm autosamplers. The neck of a screw thread vial is a different diameter than that of a crimp top vial, and the screw cap vial lacks the natural ledge formed by the lip of a crimp top vial. That ledge is frequently used by the autosampler to help align and lift the vial.\nWhat are the basic principles of headspace analysis?\nA headspace sample is usually prepared in a vial containing the sample, the dilution solvent, a matrix modifier, and the headspace. Volatile components from complex sample mixtures can be extracted from non-volatile sample components and isolated in the headspace or gas portion of a sample vial. A sample of the gas in the headspace is injected into a GC system for the separation of all of the volatile components. In order to achieve the best performance with headspace GC, careful attention should be paid to sample preparation and instrument setup. The vial and cap are very important, and often overlooked, elements in the headspace analysis preparation.\nIt is important to ensure the correct vial and cap are used!\nHeadspace vials are available in 6, 10, and 20 ml sizes. Use a vial large enough to ensure adequate headspace or phase ratio without excessive dilution of the components of interest. The phase ratio is discussed later and should normally be at least 50 % of the sample volume.\nHeadspace vials may be round-bottomed or flat-bottomed. Either type is suitable but round-bottomed vials tend to be stronger and may work more reliably when the autosampler moves the vials into and out of the incubator. Round-bottomed vials also tend to withstand higher pressures and are more suitable for elevated temperatures and applications such as derivatization.\nHeadspace vials must be correctly crimped. Ensure the crimper is not worn and is adjusted correctly. The cap should not turn after application to the vial. Find out more about correct vial crimping.\nUse septa suitable for the temperature of the system. Poor septa Poor septa can result in bleed and so contaminate the headspace.\nCleanliness of Vial\nVials should be clean. Not all vials are the same and dirty or re-washed vials can cause ghost peaks or erroneous results.\nAt Growing Labs, we don’t sell name-brand headspace vials. Small and medium labs don’t have the budget to waste on vanity name brands; they buy acetaminophen, not Tylenol because it’s the same thing – except much cheaper. That’s one of our specialties: offering equivalent alternatives so that our customers can save on budget. So if you are interested in headspace vials and want to know more details about them, welcome to the Web.\nBack to List\n下午4:09Weighing the Pros and Cons of PTFE/Silicone Septa\n下午4:05Decoding Vial Discard Guidelines: Ensuring Precision in Chromatography\n下午5:01Navigating Micro Inserts for HPLC Vials: A Comprehensive Guide\n下午2:02Common faults and solutions of automatic samplers(2)\n下午5:08Ensuring Sample Integrity: Navigating EPA Storage Vials Stability Guidelines", "domain": "chemistry", "round": 3} +{"url": "http://stke.sciencemag.org/content/2000/18/tw5", "date": "2017-05-23T09:25:42Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-22/segments/1495463607593.1/warc/CC-MAIN-20170523083809-20170523103809-00041.warc.gz", "language_score": 0.9062297344207764, "token_count": 347, "dump": "CC-MAIN-2017-22", "global_id": "webtext-fineweb__CC-MAIN-2017-22__0__191953990", "lang": "en", "text": "Large protein binding regions such as the SH2, SH3, and PH domains are critically important for the proper association and alignment of protein partners and their subsequent transmittal of intracellular signals. In comparison, the specific ligands for these binding domains are quite small, with specificity usually conferred within a span of seven or eight amino acids. Tanoue et al. have uncovered new docking motifs in MAP kinases and their upstream and downstream counterparts. A small cluster of negatively charged residues on the MAPKs ERK1 and ERK2, with the core consensus D-P/T-E/D/S/T-D/E [referred to as the common docking (CD) motif], electrostatically interacted with a cluster of positively charged residues found on their activators, inactivators, and substrates. Coexpression studies revealed that mutation of either charged cluster severely abrogated protein-protein binding, whereas in vitro kinase experiments demonstrated that the docking interactions increased enzymatic activity. Additionally, only one protein at any given time could bind the MAPK CD motif. Thus, it is conceivable that phosphorylation or dephosphorylation of MAPKs and the proteins that associate with them may induce conformation changes that allow one protein to dissociate as another binds to the CD motif. Such a mechanism might contribute to specific hierarchical signal transduction in MAPK pathways.\nTanoue, T., Adachi, M., Moriguchi, T., and Nishida, E. (2000) A conserved docking motif in MAP kinases common to substrates, activators and regulators. Nat. Cell Biol. 2: 110-116. [Online Journal]", "domain": "chemistry", "round": 3} +{"url": "https://www.ezelpremium.com/en/blog/how-to-clean-washing-machine-heating-element/", "date": "2023-06-06T01:48:24Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-23/segments/1685224652207.81/warc/CC-MAIN-20230606013819-20230606043819-00072.warc.gz", "language_score": 0.9271957278251648, "token_count": 900, "dump": "CC-MAIN-2023-23", "global_id": "webtext-fineweb__CC-MAIN-2023-23__0__173072575", "lang": "en", "text": "Preventing limescale buildup in your washing machine can improve its performance and result in cleaner, more hygienic clothes, while also extending its lifespan. One of the most common problems with washing machines is limescale buildup on the heating element or “resistance.” The resistance heats the water during the wash cycle, making it more effective. However, over time, limescale buildup on the resistance can reduce its performance and even cause it to break down.\nTo prevent limescale buildup in your washing machine, you can follow these tips:\nUse the right detergent: The type and amount of detergent you use can affect limescale buildup. Make sure the detergent you use is suitable for your washing machine, and avoid using too much, as this can lead to limescale buildup in the machine.\nCheck the hardness of your water:\nThe hardness of your water is an important factor in limescale buildup. The hardness of water can vary depending on your location, and washing machines in areas with hard water are more prone to limescale buildup. You can use water softeners to soften hard water.\nClean your washing machine regularly:\nRegular cleaning of your washing machine is important to prevent limescale buildup. After each use, wash your machine with warm water. You can also use special cleaners to remove any dirt or buildup inside your washing machine.\nClean your washing machine’s filters regularly:\nFilters in your washing machine help to trap dirt and prevent limescale buildup. Regularly cleaning your filters can help reduce limescale buildup in your machine and improve its performance.\nGet professional help when the resistance becomes limescale:\nWhen the resistance in your washing machine becomes limescale, it can reduce the machine’s performance and even cause it to break down. Therefore, it is important to seek professional help when this happens. Calling a technician can help to replace or clean the resistance as necessary.\nYour washing machine is an important part of your home cleaning routine. By cleaning it regularly and following these tips, you can prevent limescale buildup, improve its performance, and achieve cleaner clothes. However, if the resistance becomes limescale, it is important to seek professional help to prevent any further damage to your machine.\nHow to clean a heating element?\nIf we turn to cleaning the heating element, washing machines are among the essentials of our lives. However, when regular maintenance is not performed, we may encounter many problems over time. One of these problems is the limescale buildup on the washing machine’s heating element. The heating element heats the water to provide better cleaning for our laundry. However, calcium and magnesium ions in hard water cause limescale buildup on the heating element. This leads to increased energy consumption and eventually permanent damage.\nTo prevent this problem, the washing machine’s heating element needs to be cleaned regularly. There are different methods for cleaning the heating element. However, it is important that the applied methods do not damage the plastic parts in the machine.\nSubstances such as citric acid or acetic acid can be used to clean the washing machine’s heating element. However, it should not be forgotten that these substances can deform plastic parts in the machine due to their abrasive properties. Therefore, using washing machine cleaning tablets is a safer option.\nIn addition, vinegar can also be used to clean the washing machine’s heating element. Simply mix two cups of white vinegar with one liter of water and add it to the drum and detergent compartment of the machine. Run the machine on a short program at a high temperature, and that’s it. However, care should be taken when using vinegar. While it may not cause any problems with older machines, it can cause rusting in newer generation washing machines.\nTo prevent your machine from going out of warranty and for a safer and more effective option, you can use Ezel Detergent. This detergent prevents limescale buildup on the washing machine’s heating element and ensures that your machine works smoothly for a longer time.\nIn conclusion, it is important to clean and maintain the washing machine’s heating element regularly to extend its life and ensure that it operates smoothly. Different methods can be used for cleaning the heating element, but it is important that the chosen method does not damage the machine.", "domain": "chemistry", "round": 3} +{"url": "https://www.co2meter.com/products/tr250z-oxygen-sensor-1", "date": "2017-04-24T03:23:03Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-17/segments/1492917118963.4/warc/CC-MAIN-20170423031158-00563-ip-10-145-167-34.ec2.internal.warc.gz", "language_score": 0.8552220463752747, "token_count": 332, "dump": "CC-MAIN-2017-17", "global_id": "webtext-fineweb__CC-MAIN-2017-17__0__78111430", "lang": "en", "text": "CM-0134 25% O2 Transmitter\nCM-0134-WT 25% O2 Transmitter with Tube Sampling\nCM-0150 25% O2 with Mount Shield\nCM-0160 95% O2 Transmitter\nCM-0160-WT 95% O2 Transmitter with Tube Sampling\nCM-0161 95% O2 with Mount Shield\nThe TR250Z is a long life 0-25% or 0.1-95% oxygen level transmitter that provides multiple analog linear outputs of O2 concentrations. It is designed to be rugged, maintenance-free and can be calibrated in normal air of any known oxygen concentration. Multiple transmitters may be daisy chained for via RS485, base address for each sensor is via on board jumper.\nThe Fujikura oxygen sensor used in the TR250Z is a zirconium based, current limiting sensor. This style of sensor has many advantages over other ways of measuring oxygen. For example, it does not require periodic calibration or replacement. If the air is clean, once the sensor or sensor assembly is calibrated to the electronics that drive the heater circuit and read the output, you do not have to reset them. The sensor will last at least 3 years and more if the guidelines for use are followed. Most competitive chemical cell types last 6 months to a year.\nReference gases are not required for proper operation or set up as is the case with Zirconia Concentration Cell or galvanic cell sensors.\nAccuracies of +/- 0.5% oxygen concentration are standard with these sensors. Chemical cells typically run 2 to 5%.", "domain": "chemistry", "round": 3} +{"url": "http://ielts-studies.tk/fiberglas-insulation-material-safety-data-sheet.html", "date": "2019-07-23T20:12:02Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-30/segments/1563195529664.96/warc/CC-MAIN-20190723193455-20190723215455-00423.warc.gz", "language_score": 0.7225854992866516, "token_count": 666, "dump": "CC-MAIN-2019-30", "global_id": "webtext-fineweb__CC-MAIN-2019-30__0__19978465", "lang": "en", "text": "SAFETY DATA data SHEET Personal Protective Equipment Protective material Gloves Safety Glasses IATA Pictograms. 44964- NAM- EN Recommended Use Insulation Contact manufacturer Owens Corning Insulating Systems LLC One safety material Owens Corning Parkway Toledo safety OH 43659. Product Data Sheet sheet 700 Series FIBERGLAS™ Insulation. The Safety Data Sheet ( SDS) search page allows you to material search safe use instruction fiberglas sheets ( SUIS) , locate safety data sheets ( SDS) safety article declaration letters ( ADL) for the products sold by Owens Corning across data the globe. Insulation VaporWick®, Vitro Fibras Pipe Insulation . Fiberglass white blowing wool insulation. Material placed against a solid data backing.\nInsulation VaporWick®, Evolution™ Paper- Free ASJ, Vitro Fibras Pipe Insulation Aislamiento para Tuberia. 1000° fiberglass pipe fiberglas insulation: insulation 1000° earthwool pipe insulation with ecose tech:. However any manufacturer' s sheets , , the data thereon regulations concerning such sheets are subject to change. There is no known ecological information for this material. MATERIAL SAFETY DATA SHEET – Pipe , Tank Insulation ( Fiberglass) 08/ 25/ 06 Great Lakes Textiles P& T Ins FBLLS PROTECTIVE CLOTHING: Wear loose fitting, long sleeved data shirt that covers to the base of fiberglas the neck long pants. There is no insulation known ecological information for. SAFETY DATA SHEET Personal Protective Equipment.\nproduct submittal sheets and safety material safety data sheets. SAFETY DATA SHEET Personal Protective Equipment Protective Gloves Safety Glasses IATA Pictograms SECTION 1 : IDENTIFICATION Product Name: Low Density Fiber Glass Insulation/ Insulation Board - Unfaced Products. Product Data Sheet 700 Series FIBERGLAS. to store the material safety data material sheets you material need to. Fiberglas insulation material safety data sheet. faced material on outer layer only.\nPink fiberglas Insulation,. PRODUCT and COMPANY IDENTIFICATION Generic Product Name fiberglas Low Density Fiber Glass Insulation/ Insulation Board – Faced Products. check insulation for a newer version of a safety data sheet search our.\nMATERIAL SAFETY DATA SHEET. MATERIAL SAFETY DATA SHEET Fiberglass Cloth - Pg 2. drink or tobacco in work area or material storage areas. Material Safety Data Sheet Material Name: Fiberglas® Duct Liner Board MSDS No: 15- MSD_ _ _ _ _ Page 3 of 9 Issue Date: 11/ 30/ 04 North America - English Hazardous Combustion Products: Primary combustion products are carbon monoxide, carbon dioxide, ammonia, and water.\nfiberglas insulation material safety data sheet\nMATERIAL SAFETY DATA SHEET _ _ _ _ _ Page 1/ 7 NFPA WHMIS Personal Protective Equipment Transport Symbol not regulated Preparation Date: 16- December- 1997 Revision Date 17- July- Revision Number 20 1. PRODUCT and COMPANY IDENTIFICATION Generic Product Name Low Density Fiber Glass Insulation/ Insulation Board – Unfaced Products.", "domain": "chemistry", "round": 3} +{"url": "https://mayoclinic.pure.elsevier.com/en/projects/nucleic-acids-gordon-conference", "date": "2021-10-26T10:51:40Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-43/segments/1634323587877.85/warc/CC-MAIN-20211026103840-20211026133840-00291.warc.gz", "language_score": 0.9173754453659058, "token_count": 252, "dump": "CC-MAIN-2021-43", "global_id": "webtext-fineweb__CC-MAIN-2021-43__0__53048475", "lang": "en", "text": "The purpose of the Conference is to encourage the transfer of ideas and information within the community of scientists who work at the forefront of nucleic acids research, an area long recognized as critical for all of the biological sciences. An important aspect of the Gordon Conference on Nucleic Acids is that it brings scientists that work on the structural and chemical aspects of nucleic acids together with those who are more biologically oriented. It also brings together scientists working on RNA with those working on DNA. Because of its breadth, the Nucleic Acids Gordon Conference has continued to play a seminal role in its field, despite the proliferation of subspecialty meetings. A broad range of speakers and participants will be sought for the 1999 Conference, with scientific accomplishment and potential being the main criteria for admission. Conferees will be encouraged to participate both in the formal lecture/discussion sessions, and less formally in poster presentations.\n|Effective start/end date||7/1/99 → 6/30/00|\n- National Institute of General Medical Sciences\n- Biochemistry, Genetics and Molecular Biology(all)\nExplore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.", "domain": "chemistry", "round": 3} +{"url": "https://pparsignaling.com/x-linked-hypophosphatemic-osteomalacia-together-with-phex-mutation-delivering-late-inside-pakistan/", "date": "2023-12-03T00:47:52Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100476.94/warc/CC-MAIN-20231202235258-20231203025258-00487.warc.gz", "language_score": 0.9009029269218445, "token_count": 901, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__207646648", "lang": "en", "text": "In glioblastoma, the commonest and also dangerous grownup brain tumour, the metabolism move towards cardio exercise glycolysis is observed, along with rules by recognized body’s genes while integrants associated with oncogenic paths including phosphoinositide 3-kinase/protein kinase, MYC, along with hypoxia governed gene because hypoxia activated 4-PBA mw aspect 1. Your expression report of the set of body’s genes html coding regarding glycolysis along with the tricarboxylic acid solution cycle throughout glioblastoma cases verifies this kind of metabolism Doxycycline move. A comprehension of precisely how the principle metabolism walkways EHT 1864 research buy tend to be changed by simply cancer malignancy tissue along with the relationships in between oncogenes and tumor suppressor genes with these path ways may possibly illuminate brand-new methods inside cancers therapy. In our evaluation, the main metabolic path ways are compared throughout typical along with cancer malignancy cells, as well as important laws by the primary oncogenes and tumour suppressant genes are discussed. Probable beneficial targets from the cancer lively metabolic process are generally enumerated, featuring the particular astrocytomas, the most typical human brain most cancers.A few inorganic-organic crossbreed compounds according to Keggin-type polyoxometalate (POM) and also Ni-II-bis(triazole) complexes, that is, [Ni-2(L-1)(4)(SiW12O40)] middle dot Drinking water (1), [Ni-2(H2O)(Some)(L-2)(4)(HL2)(Two)]-[PMo12O40](Two) heart dept of transportation 2H(2)O (Two), as well as [Ni-3(L-1)(5) [PMo12P40](Only two) center dot 14H(Only two)O (Three) (L-1 Is equal to 1,4-bis(1,Two,4-triazol-1-yl)butane, L-2 = 1,6-bis (1,Two,4-triazol-1-yl)-hexane), happen to be obtained beneath hydrothermal circumstances and also structurally seen as an single-crystal X-ray diffraction analyses, important examines, IR spectra, along with thermogravimetric (TG) analyses. Chemical substance 1 demonstrates a (Six(Some)) three-dimensional (3 dimensional) Ni-L-1 framework along with hexagonal programs, by which [SiW12O40](4-) anions are already covered as tetradentate linkages. Within chemical substance Only two, the particular Ni-L-2 motif demonstrates the Animations supramolecular system templated through [PMo12O40](3-) (PMo12) anions. In substance 3, the particular Ni-L-1 motif is a two-dimensional (2D) covering, which can be connected simply by PMo12a anions to make a new 3 dimensional composition. The particular 3 dimensional frameworks interpenetrate collectively to form a 2-fold interpenetrating structure, which reveals 2 types of programs. Another under the radar PMo12b anions, acting as inorganic themes, take root from the more substantial routes. The Keggin anions within Several exert not merely linkage but also web template roles. In addition, electrochemical qualities associated with 1-bulk changed carbon paste electrode (1-CPE) and 3-CPE happen to be examined within 1 M H2SO4 aqueous solution.The tritium inventory inside plasma-facing materials (PFMs) is a issue throughout combination reactors. Tungsten (M), that is a prospect PFM, includes a suprisingly low solubility pertaining to hydrogen isotopes, nevertheless inbuilt and radiation-induced problems can keep a lot of hydrogen. A new positron termination technique was applied to investigate the particular interactions between deuterium (Deborah) and also openings throughout W drawn simply by Cu ions. The outcome revealed that opportunities were shaped in Wafter Cu ion irradiation, knowning that Deborah atoms ended up caught by simply these kinds of opportunities.", "domain": "chemistry", "round": 3} +{"url": "http://www.hpclubricants.in/products.html", "date": "2023-12-09T07:46:19Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100873.6/warc/CC-MAIN-20231209071722-20231209101722-00611.warc.gz", "language_score": 0.9434139728546143, "token_count": 702, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__312427017", "lang": "en", "text": "We are distributing an extensive range of Compressor Oil. It is a necessary component in any air conditioning system. This oil is used for lubrication also. It reduces the wear and tear on rotating parts by using various additives.\nWe are involved in rendering a broad array of Cutting Oil. It provides basic friction protection to the engine. This oil is designed to maximise the life of cutting and drilling equipment. It is an oil which improves machine finish and to reduce the tip welding.\nOur firm is instrumental in dealing a wide array of Engine Oil. It provides basic friction protection to the engine. This oil is efficiently doing the run-in period of the vehicle. It is highly effective in racing motor cycle engine to give a better lubrication.\nWe are offering a broad assortment of Gear Oil to our clients. This oil is designed for use in transmissions and to transfer cases in your car or truck. It is helpful your transmission run smoothly. It provides an excellent gear and bearing protection.\nBeing a reliable firm, we are offering a wide ambit of Hydraulic And Compressor Oil. It prevents metal from rubbing against metal. It lubricates the rotors and seals the compression chamber. Provided oil requires a frequent maintenance and repairs.\nMatching to the needs of consumers, we are offering a unique range of Industrial Grease. It is used to keep vehicles, machines and others. This grease is able to reduce the friction, binding, wear and so on. It aids to modify surface properties.\nWe are offering a wide array of Lubricant Oil. It is used to reduce the friction and wear between mechanical components. It is suitable in motorized vehicles. Provided oil is also helps to control the friction between load-bearing surface lubricating oil.\nWe are actively engaged in providing a broad array of Machine Oil. It is to lubricate the engine parts and reduce friction. It is designed to protect the metal surfaces. Provided oil prevents the metal surface from any type of corrosion.\nOwing to rapid growth in business realm, we are offering a wide array of Metal Drawing Compound. It is used to shape the metal. This compound is to improve the surface finish of the metal being drawn. It is also used in deep drawing.\nWe are affianced in providing a supreme range of Quenching Oil. It facilitates hardening of steel by controlling heat transfer during quenching. This oil absorbs more initial heat and cool for longer periods of time. It ensures an excellent thermal stability.\nOur firm has gained a dynamic position in providing a superior range of Rubber Process Oil. It is used to reduce the blending temperatures during processing. It modifies the physical properties. It is used for the manufacturing of various rubber produces.\nRust Preventive Oil is ideally used to protect components previously exposed to water containing machines. This oil is suitable in humid conditions. It is ideal for inter-process rust protection. It is able to give a short term and long term protection.\nWe are supplying a broad array of Transformer Oil. It is used to insulate high-voltage electrical infrastructure. It is designed to operate effectively at very high temperatures. This oil is used in transformers for its chemical properties.\nBeing a client centric organization, we are offering a broad variety of Turbine Oil to our patrons. This oil is able to provide an efficient cooling and prevent sludge. It is used to lubricate the bearings and auxiliary machinery in steam.", "domain": "chemistry", "round": 3} +{"url": "https://drlauraclinic.ie/products/skinceuticals-discolouration-defense-serum", "date": "2022-01-21T23:10:16Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-05/segments/1642320303717.35/warc/CC-MAIN-20220121222643-20220122012643-00131.warc.gz", "language_score": 0.7168965935707092, "token_count": 332, "dump": "CC-MAIN-2022-05", "global_id": "webtext-fineweb__CC-MAIN-2022-05__0__9319900", "lang": "en", "text": "SkinCeuticals Discolouration Defense Serum\nThe Discolouration Defense Serum from SkinCeuticals, a daily-use pigmentation corrector that is proven to correct and brighten the skin. This specialist formula combines a number of key actives to reduce the appearance of the most hard-to-treat forms of pigmentation including dark spots and post-acne marks.\nHigh-potency serum targets visible skin discolouration for brighter, more even-looking skin.\nHow to use\n- Twice daily, apply 3-5 drops of Discoloration Defense serum to the face and neck\n- If using in the morning, apply after a vitamin C serum and follow with a broad spectrum SPF 30+ sunscreen\n- Limit sun exposure while using this product\nGreat all rounder serum for pigmentation.\n1.8% TRANEXAMIC ACID\n5% HEPESAQUA / WATER, BUTYLENE GLYCOL, NIACINAMIDE, HYDROXYETHYLPIPERAZINE ETHANE SULFONIC ACID, GLYCERIN, HYDROXYETHYL UREA, PROPYLENE GLYCOL, TRANEXAMIC ACID, PHENOXYETHANOL, CAPRYLYL GLYCOL, ALLANTOIN, CHLORPHENESIN, XANTHAN GUM, DISODIUM EDTA (D227872/1).", "domain": "chemistry", "round": 3} +{"url": "https://www.idcafe.net/what-are-the-9-igneous-rocks/", "date": "2023-10-02T00:19:18Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233510942.97/warc/CC-MAIN-20231002001302-20231002031302-00135.warc.gz", "language_score": 0.9207252860069275, "token_count": 854, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__162636493", "lang": "en", "text": "What are the 9 igneous rocks?\nThese rocks include: andesite, basalt, dacite, obsidian, pumice, rhyolite, scoria, and tuff. Pictures and brief descriptions of some common igneous rock types are shown on this page. Dacite is a fine-grained, extrusive igneous rock that is usually light in color.\nWhat are the example of igneous rock?\nThere are two basic types: 1) intrusive igneous rocks such as diorite, gabbro, granite and pegmatite that solidify below the Earth’s surface; and 2) extrusive igneous rocks such as andesite, basalt, obsidian, pumice, rhyolite and scoria that solidify on or above the Earth’s surface.\nWhat are the main types of igneous rocks?\nThe two main categories of igneous rocks are extrusive and intrusive. Extrusive rocks are formed on the surface of the Earth from lava, which is magma that has emerged from underground. Intrusive rocks are formed from magma that cools and solidifies within the crust of the planet.\nWhat are characteristics of igneous rocks?\nCharacteristics of Igneous Rocks\n- The igneous form of rocks does not include any fossil deposits.\n- Most igneous forms include more than one mineral deposit.\n- They can be either glassy or coarse.\n- These usually do not react with acids.\n- The mineral deposits are available in the form of patches with different sizes.\nIs sand an igneous rock?\nSand can be divided into three main categories: Mineral sands are formed by weathering (mechanical and chemical breakdown) of igneous (plutonic or volcanic), metamorphic or sedimentary rocks. These minerals are some of the earliest to form in igneous rock bodies because of their high temperatures of crystallization.\nWhat are igneous rocks characteristics?\nCharacteristics of Igneous Rocks The igneous form of rocks does not include any fossil deposits. Most igneous forms include more than one mineral deposit. They can be either glassy or coarse. These usually do not react with acids. The mineral deposits are available in the form of patches with different sizes.\nWhat are uses for igneous rocks?\nIgneous rocks have a wide variety of uses. One important use is as stone for buildings and statues. Diorite was used extensively by ancient civilizations for vases and other decorative artwork and is still used for art today (Figure 1). Granite (figure 2) is used both in building construction and for statues.\nWhat characteristics make igneous rocks useful?\nWhat characteristics make igneous rock useful? Igneous rocks are useful because they are hard, dense, and durable.\nWhat are the two types of igneous rocks?\nThe two main categories of igneous rocks are extrusive and intrusive. Extrusive rocks are formed on the surface of the Earth from lava, which is magma that has emerged from underground.\nWhere does magma form in an intrusive igneous rock?\nIntrusive Igneous Rock. Intrusive, or plutonic, igneous rock forms when magma remains inside the Earth’s crust where it cools and solidifies in chambers within pre-existing rock.\nWhere can I find igneous rocks in the United States?\nVolcanic processes has shaped the extrusive igneous rock formations at these parks: Hawai’i Volcanoes National Park, Hawai’i [Geodiversity Atlas] [Park Home] Sunset Crater Volcano National Monument, Arizona [Geodiversity Atlas] [Park Home] Crater Lake National Park, Oregon [Geodiversity Atlas] [Park Home]\nHow are the crystals in an igneous rock affected?\nThe size of mineral crystals in an igneous rock may indicate the rate at which the lava or magma cooled to form a rock. Crystal size can also be affected by the number of gases or the availability of the chemicals in the molten rock that are required to form the crystals.", "domain": "chemistry", "round": 3} +{"url": "https://insights.ovid.com/molmic/201602010/00005797-201602010-00010", "date": "2018-12-15T07:24:59Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-51/segments/1544376826800.31/warc/CC-MAIN-20181215061532-20181215083532-00607.warc.gz", "language_score": 0.9112311601638794, "token_count": 366, "dump": "CC-MAIN-2018-51", "global_id": "webtext-fineweb__CC-MAIN-2018-51__0__60363855", "lang": "en", "text": "During amino acid starvation, bacterial cells rapidly synthesize the nucleotides (p)ppGpp, causing a massive re-programming of the transcriptional profile known as the stringent response. The (p)ppGpp synthase RelA is activated by ribosomes harboring an uncharged tRNA at the A site. It is unclear whether synthesis occurs while RelA is bound to the ribosome or free in the cytoplasm. We present a study of threeEscherichia colistrains, each expressing a different RelA-fluorescent protein (RelA-FP) construct: RelA-YFP, RelA-mEos2 and RelA-Dendra2. Single-molecule localization and tracking studies were carried out under normal growth conditions and during amino acid starvation. Study of three labeling schemes enabled us to assess potential problems with FP labeling of RelA. The diffusive trajectories and axial spatial distributions indicate that amino acid starvation induces net binding of all three RelA-FP constructs to 70S ribosomes. The data are most consistent with a model in which RelA synthesizes (p)ppGpp while bound to the 70S ribosome. We suggest a ‘short hopping time’ model of RelA activity during starvation. Our results contradict an earlier study of RelA-Dendra2 diffusion that inferred off-ribosome synthesis of (p)ppGpp. The reasons for the discrepancy remain unclear.\nSingle-molecule localization and tracking measurements were carried out for RelA labeled with three different fluorescent proteins, in normal growth conditions and under amino acid starvation. The results support a model in which RelA synthesizes (p)ppGpp while bound to the 70S ribosome.", "domain": "chemistry", "round": 3} +{"url": "http://www.drexelmed.edu/Home/AboutOurFaculty/AlexanderMazin.aspx", "date": "2013-05-23T05:22:47Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2013-20/segments/1368702849682/warc/CC-MAIN-20130516111409-00004-ip-10-60-113-184.ec2.internal.warc.gz", "language_score": 0.7866167426109314, "token_count": 1224, "dump": "CC-MAIN-2013-20", "global_id": "webtext-fineweb__CC-MAIN-2013-20__0__15388565", "lang": "en", "text": "Our studies focus on the mechanisms of homologous recombination in humans. The homologous recombination pathway is crucial for maintenance of genome stability. It promotes the repair of the most harmful DNA lesions: DNA double-stranded breaks and inter-strand cross-links. In addition, homologous recombination is important for faithful segregation of homologous chromosomes during meiosis. Deficiencies in homologous recombination lead to cancer, premature aging, and various chromosomal abnormalities such as Down, Klinefelter, and other syndromes.\nTo achieve accurate repair of DNA double-stranded breaks the homologous recombination machinery uses homologous dsDNA as a template. The unique and evolutionary conserved mechanism of homologous recombination is responsible for recognition of homologous DNA sequences and their pairing. However, the molecular principles of this mechanism remain a mystery. To uncover these principles our lab investigates the biochemical activities of the key homologous recombination proteins including RAD51, its meiosis-specific homologue DMC1, RAD52, RAD54, and others. Using homologous recombination proteins we attempt to reconstitute the process DNA double strand break repair in vitro.\nSince the homologous recombination activity is vital for rapidly proliferating cells and may be protective against the killing effect of anti-cancer drugs, we are developing specific small-molecule inhibitors of key homologous recombination proteins. We will use these inhibitors for advancement of novel anti-cancer therapies. In addition, these inhibitors can be used as a probe to analyze the functions of homologous recombination proteins in the cell.\n“Polarity and bypass of DNA heterology during branch migration of Holliday junctions by human RAD54, BLM, and RECQ1”\nMazina, OM., Rossi, MJ, Deakyne, JS, Huang, F., and Mazin, AV\nJ. Biol. Chem. 287, 11820-11832 (2012).\n“Inhibition of homologous recombination in human cells by targeting RAD51 recombinase”\nHuang, F., Mazina, OM., Zentner, IJ, Cocklin, S., and Mazin, AV.\nJ. Medicinal Chemistry 55, 3011-3020 (2012). Rated twice as a “must read” by Faculty of 1000.\n\"The RecA/RAD51 protein drives migration of Holliday junctions via polymerization on DNA. \"\nRossi, MJ, Mazina, OM, Bugreev, DV, and Mazin, AV.\nProc Natl Acad Sci USA 108, 6432-6437 (2011).\n“The resistance of DMC1 D-loops to dissociation may account for the DMC1 requirement in meiosis”\nBugreev, DV, Pezza, RJ, Mazina, OM, Voloshin, ON, Camerini-Otero RD, and Mazin AV.\nNature Struct. & Mol. Biol., 18, 56-60 (2011).\n\"Cooperation of RAD51 and RAD54 in regression of a model replication fork.\"\nBugreev, DV, Rossi, MJ, and Mazin, AV.\nNucleic Acids Res,.39, 2153-2164 (2011). Rated a “must read” by Faculty of 1000.\n“Rad54, the motor of homologous recombination”\nMazin, AV, Mazina, OM, Bugreev, DV, Rossi. MJ.\nDNA Repair (Amst) 9:286-302 (2010).\n“Bloom syndrome helicase stimulates RAD51 DNA strand exchange activity through a novel mechanism”\nBugreev, DV, Mazina, OM, and Mazin, AV\nJ. Biol. Chem. 284, 26349-26359 (2009).\nHuman Rad54 protein stimulates human Mus81/Eme1 endonuclease.\nMazina, OM., Mazin, AV\nProc. Natl. Acad. Sci. USA, 105(47): p. 18249-18254 (2008).\n\"Novel pro- and anti-recombination activities of the Bloom’s syndrome helicase\"\nBugreev, DV, Yu, X, Egelman, EH, Mazin, AV\nGenes & Development, 21: 3085-3094 (2007).\n\"Interactions of human Rad54 protein with branched DNA molecules\"\nMazina, OM, Rossi, MJ, Thoma, N, and Mazin, AV\nJ. Biol. Chem., 282 (29): 21068-21080 (2007).\n\"Rad54 dissociates homologous recombination intermediates by branch migration\"\nBugreev, DV, Hanaoka, F, and Mazin, AV\nNature Struct. & Mol. Biol., 14 (8): 746-753 (2007).\n\"Rad54 protein promotes branch migration of the Holliday junctions\"\nBugreev, DV, Mazina, OM, and Mazin, AV\nNature (London). 442: 590-593 (2006). Reviewed by Faculty of 1000 Biology\n\"Ca2+ activates human homologous recombination protein Rad51 by modulating its ATPase activity\"\nBugreev, DV, and Mazin, AV\nProc. Natl. Acad. Sci. USA, 101: 9988-9993 (2004).\n\"Human Rad54 protein stimulates DNA strand exchange activity of hRad51 protein in the presence of Ca2+\"\nMazina, OM, and Mazin, AV\nJ. Biol. Chem., 279: 52041-52051 (2004). Selected by the JBC editors as a Paper of the Week", "domain": "chemistry", "round": 3} +{"url": "http://www.jmb.or.kr/journal/view.html?doi=10.4014/jmb.2001.01004", "date": "2020-04-01T13:52:29Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-16/segments/1585370505731.37/warc/CC-MAIN-20200401130837-20200401160837-00426.warc.gz", "language_score": 0.6640512943267822, "token_count": 2676, "dump": "CC-MAIN-2020-16", "global_id": "webtext-fineweb__CC-MAIN-2020-16__0__104236337", "lang": "en", "text": "2020 ; Vol.30-2: 155~162\n|Author||Min-Jeong Kim, Myoung-Uoon Jang, Gyeong-Hwa Nam, Heeji Shin, Jeong-Rok Song, Tae-Jip Kim|\n|Place of duty||Division of Animal, Horticultural and Food Sciences, Graduate School of Chungbuk National University, Cheongju 28644, Republic of Korea|\n|Title||Functional Expression and Characterization of Acetyl Xylan Esterases CE Family 7 from Lactobacillus antri and Bacillus halodurans|\nJ. Microbiol. Biotechnol.2020 ;\n|Abstract||Acetyl xylan esterase (AXE; E.C. 220.127.116.11) is one of the accessory enzymes for xylan\ndegradation, which can remove the terminal acetate residues from xylan polymers. In this\nstudy, two genes encoding putative AXEs (LaAXE and BhAXE) were cloned from Lactobacillus\nantri DSM 16041 and Bacillus halodurans C-125, and constitutively expressed in Escherichia coli.\nThey possess considerable activities towards various substrates such as p-nitrophenyl acetate,\n4-methylumbelliferyl acetate, glucose pentaacetate, and 7-amino cephalosporanic acid. LaAXE\nand BhAXE showed the highest activities at pH 7.0 and 8.0 at 50oC, respectively. These\nenzymes are AXE members of carbohydrate esterase (CE) family 7 with the cephalosporine-C\ndeacetylase activity for the production of antibiotics precursors. The simultaneous treatment\nof LaAXE with Thermotoga neapolitana β-xylanase showed 1.44-fold higher synergistic\ndegradation of beechwood xylan than the single treatment of xylanase, whereas BhAXE\nshowed no significant synergism. It was suggested that LaAXE can deacetylate beechwood\nxylan and enhance the successive accessibility of xylanase towards the resulting substrates.\nThe novel LaAXE originated from a lactic acid bacterium will be utilized for the enzymatic\nproduction of D-xylose and xylooligosaccharides.|\n|Key_word||Acetyl xylan esterases, carbohydrate esterase (CE) family 7, synergistic xylan degradation, Lactobacillus antri, Bacillus halodurans|\nHuang YC, Chen GH, Chen YF, Chen WL, Yang CH. 2010. Heterologous expression of thermostable acetylxylan esterase gene from Thermobifida fusca and its synergistic action with xylanase for the production of xylooligosaccharides. Biochem. Biophys. Res. Commun. 400: 718-723.\nZheng F, Huang J, Yin Y, Ding S. 2013. A novel neutral xylanase with high SDS resistance from Volvariella volvacea:characterization and its synergistic hydrolysis of wheat bran with acetyl xylan esterase. J. Ind. Microbiol. Biotechnol. 40: 1083-1093.\nHettiarachchi SA, Kwon YK, Lee Y, Jo E, Eom TY, Kang YH, et al. 2019. Characterization of an acetyl xylan esterase from the marine bacterium Ochrovirga pacifica and its synergism with xylanase on beechwood xylan. Microb. Cell Fact. 18: 122.\nMalgas S, Mafa MS, Mkabayi L, Pletschke B. 2019. A mini review of xylanolytic enzymes with regards to their synergistic interactions during hetero-xylan degradation. World J. Microbiol. Biotechnol. 35(12): 187.\nBiely P. 2012. Microbial carbohydrate esterases deacetylating plant polysaccharides. Biotechnol. Adv. 30: 1575-1588.\nPoeker SA, Geirnaert A, Berchtold L, Greppi A, Krych L, Steinert RE, et al. 2018. Understanding the prebiotic potential of different dietary fibers using an in vitro continuous adult fermentation model (PolyFermS). Sci. Rep. 8: 4318.\nAdesioye FA, Makhalanyane TP, Biely P, Cowan DA. 2016. Phylogeny, classification and metagenomic bioprospecting of microbial acetyl xylan esterases. Enzyme Microb. Technol. 93-94: 79-91.\nSista Kameshwar AK, Qin W. 2018. Understanding the structural and functional properties of carbohydrate esterases with a special focus on hemicellulose deacetylating acetyl xylan esterases. Mycology 9: 273-295.\nMitsushima K, Takimoto A, Sonoyama T, Yagi S. 1995. Gene cloning, nucleotide sequence, and expression of a cephalosporinC deacetylase from Bacillus subtilis. Appl. Environ. Microbiol. 61: 2224-2229.\nDegrassi G, Kojic M, Ljubijankic G, Venturi V. 2000. The acetyl xylan esterase of Bacillus pumilus belongs to a family of esterases with broad substrate specificity. Microbiology 146: 1585-1591.\nLevisson M, Han GW, Deller MC, Xu Q, Biely P, Hendriks S, et al. 2012. Functional and structural characterization of a thermostable acetyl esterase from Thermotoga maritima. Proteins 80: 1545-1559.\nTian Q, Song P, Jiang L, Li S, Huang H. 2014. A novel cephalosporin deacetylating acetyl xylan esterase from Bacillus subtilis with high activity toward cephalosporin C and 7-aminocephalosporanic acid. Appl. Microbiol. Biotechnol. 98: 2081-2089.\nSonawane VC. 2006. Enzymatic modifications of cephalosporins by cephalosporin acylase and other enzymes. Crit. Rev. Biotechnol. 26: 95-120.\nLiu Y, Gong G, Zhu C, Zhu B, Hu Y. 2010. Environmentally safe production of 7-ACA by recombinant Acremonium chrysogenum. Curr. Microbiol. 61: 609-614.\nViborg AH, Sørensen KI, Gilad O, Steen-Jensen DB, Dilokpimol A, Jacobsen S, et al. 2013. Biochemical and kinetic characterisation of a novel xylooligosaccharide-upregulated GH43 β-D-xylosidase/α-L-arabinofuranosidase (BXA43) from the probiotic Bifidobacterium animalis s ubsp . lactis BB-12. AMB Express 3: 56.\nMaria A, Margarita T, IIlia I, Iskra I. 2014. Gene expression of enzymes involved in utilization of xylooligosaccharides by Lactobacillus strains. Biotechnol. Biotechnol. Equip. 28: 941-948.\nPark JM, Han NS, Kim TJ. 2007. Rapid detection and isolation of known and putative α-L-arabinofuranosidase genes using degenerate PCR primers. J. Microbiol. Biotechnol. 17: 481-489.\nKhandeparker R, Jalal T. 2015. Xylanolytic enzyme systems in Arthrobacter sp. MTCC 5214 and Lactobacillus sp. Biotechnol. Appl. Biochem. 62: 245-254.\nRoos S, Engstrand L, Jonsson H. 2005. Lactobacillus gastricus sp. nov., Lactobacillus antri sp. nov., Lactobacillus kalixensis sp. nov. and Lactobacillus ultunensis sp. nov., isolated from human stomach mucosa. Int. J. Syst. Evol. Microbiol. 55: 77-82.\nTakami H, Nakasone K, Takaki Y, Maeno G, Sasaki R, Masui N, et al. 2000. Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans and genomic sequence comparison with Bacillus subtilis. Nucleic Acids Res. 28: 4317-4331.\nMargolles-Clark E, Tenkanen M, Söderlund H, Penttilä M. 1996. Acetyl xylan esterase from Trichoderma reesei contains an active-site serine residue and a cellulose-binding domain. Eur. J. Biochem. 237: 553-560.\nKoseki T, Miwa Y, Akao T, Akita O, Hashizume K. 2006. An Aspergillus oryzae acetyl xylan esterase: molecular cloning and characteristics of recombinant enzyme expressed in Pichia pastoris. J. Biotechnol. 121: 381-389.\nKrastanova I, Guarnaccia C, Zahariev S, Degrassi G, Lamba D. 2005. Heterologous expression, purification, crystallization, X-ray analysis and phasing of the acetyl xylan esterase from Bacillus pumilus. Biochim. Biophys. Acta 1748: 222-230.\nDrzewiecki K, Angelov A, Ballschmiter M, Tiefenbach KJ, Sterner R, Liebl W. 2010. Hyperthermostable acetyl xylan esterase. Microb. Biotechnol. 3: 84-92.\nShao W, Wiegel J. 1995. Purification and characterization of two thermostable acetyl xylan esterases from Thermoanaerobacterium sp. strain JW/SL-YS485. Appl. Environ. Microbiol. 61: 729-733.\nYang CH, Liu WH. 2008. Purification and properties of an acetylxylan esterase from Thermobifida fusca. Enzyme Microb. Technol. 42: 181-186.\nPark SH, Yoo W, Lee CW, Jeong CS, Shin SC, Kim HW, et al. 2018. Crystal structure and functional characterization of a cold-active acetyl xylan esterase (PbAcE) from psychrophilic soil microbe Paenibacillus sp. PLoS One 13: e0206260.\nVelikodvorskaya TV, Volkov IY, Vasilevko VT, Zverlov VV, Piruzian ES. 1997. Purification and some properties of Thermotoga neapolitana thermostable xylanase B expressed in E. coli cells. Biochemistry (Mosc) 62: 66-70.\nVincent F, Charnock SJ, Verschueren KH, Turkenburg JP, Scott DJ, Offen WA, et al. 2003. Multifunctional xylooligosaccharide/cephalosporin C deacetylase revealed by the hexameric structure of the Bacillus subtilis enzyme at 1.9Å resolution. J. Mol. Biol. 330: 593-606.\nKelley LA, Mezulis S, Yates CM, Wass MN, Sternberg MJ. 2015. The Phyre2 web portal for protein modeling, prediction and analysis. Nat. Protoc. 10: 845-858.\nSingh M K, Manoj N . 2016. A n extended loop in CE7 carbohydrate esterase family is dispensable for oligomerization but required for activity and thermostability. J. Struct. Biol. 194: 434-445.", "domain": "chemistry", "round": 3} +{"url": "http://global.rakuten.com/en/store/deco-life/item/magicalpick310b/?s-id=borderless_recommend_item_en", "date": "2016-04-29T21:06:20Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2016-18/segments/1461860111396.55/warc/CC-MAIN-20160428161511-00194-ip-10-239-7-51.ec2.internal.warc.gz", "language_score": 0.891562819480896, "token_count": 287, "dump": "CC-MAIN-2016-18", "global_id": "webtext-fineweb__CC-MAIN-2016-18__0__83060314", "lang": "en", "text": "|The official name||Magical pick 310 B （ 3 pieces ）|\n|Product description||Tip of the stick with a special adsorption resin. You can go smoothly on smeared glue on Rhinestones, such as pick up in exquisite sticking power. Tip size magical pick is smaller than the 212 P. * Tip: approx. 1.5 mm\n|Applications||-Rhinestone and Brion, little things to pick up.\nThe pickup of the microscopic model parts and semiconductors.\nTo, such as fine dust or dust removal.\n|Features||• Moderate strength without icky advanced adsorption resin absorbs repeatedly.\nAnd as you intended, such as small rhinestone and Pearl can get stuck.\nAnd can weaken the force if necessary. At your fingertips touch the tip of adsorption resin and reduced holding force. Adsorption force recovers with cleaner.\n|Attention||-Ensure that adsorption resin repeatedly with glue or nail polish, etc. and cannot be recovered, so as much as possible.\nAdsorption resins to something stronger, rub damage.\n-Use the cleaner and go decreased gradually adsorption resin.\n-By using the adsorption resins go wear out gradually.\nThis product cannot be shipped to United States from the store.\nPlease contact the store for further information.", "domain": "chemistry", "round": 3} +{"url": "https://empathi-solutions.com/qa/what-are-intrusive-and-extrusive-igneous-rocks.html", "date": "2021-05-07T21:39:27Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-21/segments/1620243988828.76/warc/CC-MAIN-20210507211141-20210508001141-00022.warc.gz", "language_score": 0.9382954835891724, "token_count": 1223, "dump": "CC-MAIN-2021-21", "global_id": "webtext-fineweb__CC-MAIN-2021-21__0__206710577", "lang": "en", "text": "- What are the three main groups of igneous rocks?\n- What are the major intrusive igneous features?\n- What are the main features of igneous rocks?\n- What is an example of an extrusive igneous rock?\n- Is an example of intrusive igneous rock?\n- What is another name for igneous rocks?\n- What is the most common type of igneous rock?\n- What is another name for extrusive igneous rocks?\n- How can you tell an intrusive igneous rock?\n- What are the 2 main types of igneous rocks?\n- Which one is not an igneous rock?\n- Which type of igneous rock has the largest crystals?\n- Which minerals are found in igneous rocks?\n- How can you tell the difference between intrusive and extrusive igneous rocks?\n- What are 5 facts about igneous rocks?\nWhat are the three main groups of igneous rocks?\nAs has already been described, igneous rocks are classified into four categories, based on either their chemistry or their mineral composition: felsic, intermediate, mafic, and ultramafic..\nWhat are the major intrusive igneous features?\nIntrusive Igneous Features and LandformsBatholiths are Plutons that have been exposed on the surface through uplift and erosion.Sills and Dikes are tabular bodies of magma that intrude into a fracture. … Monadnocks, also called Inselbergs, are isolated rock hills standing in a level plain.Feb 10, 2020\nWhat are the main features of igneous rocks?\nCharacteristics of Igneous RocksThe igneous form of rocks does not include any fossil deposits. … Most igneous forms include more than one mineral deposit.They can be either glassy or coarse.These usually do not react with acids.The mineral deposits are available in the form of patches with different sizes.Oct 27, 2020\nWhat is an example of an extrusive igneous rock?\nIf the magma contains abundant volatile components which are released as free gas, then it may cool with large or small vesicles (bubble-shaped cavities) such as in pumice, scoria, or vesicular basalt. Other examples of extrusive rocks are rhyolite and andesite.\nIs an example of intrusive igneous rock?\nIntrusive igneous rocks crystallize below Earth’s surface, and the slow cooling that occurs there allows large crystals to form. Examples of intrusive igneous rocks are: diabase, diorite, gabbro, granite, pegmatite, and peridotite.\nWhat is another name for igneous rocks?\nIgneous rocks are also known as magmatic rocks. Igneous rocks are divided into two types: plutonic and volcanic rock. Plutonic rock is another name…\nWhat is the most common type of igneous rock?\nBasaltBasalt is one of the most common types of igneous rocks in the world. The majority of the ocean floor is composed of basalt. This smooth, black igneous rock forms due to erupting magma beneath the ocean floor that cools as it comes in contact with the ocean water.\nWhat is another name for extrusive igneous rocks?\nExtrusive igneous rock, also known as volcanic rock, is formed by the cooling of molten magma on the earth’s surface.\nHow can you tell an intrusive igneous rock?\nIntrusive igneous rocks cool from magma slowly because they are buried beneath the surface, so they have large crystals. Extrusive igneous rocks cool from lava rapidly because they form at the surface, so they have small crystals. Texture reflects how an igneous rock formed.\nWhat are the 2 main types of igneous rocks?\nIgneous rocks are divided into two groups, intrusive or extrusive, depending upon where the molten rock solidifies. Intrusive Igneous Rocks: Intrusive, or plutonic, igneous rock forms when magma is trapped deep inside the Earth.\nWhich one is not an igneous rock?\nMetamorphic rocks are formed by subjecting any rock type (sedimentary rock, igneous rock or another older metamorphic rock) to different temperature and pressure conditions than those in which the original rock was formed. The correct option is C.\nWhich type of igneous rock has the largest crystals?\nThe size of the crystals depends on how quickly the molten magma solidified: magma that cools slowly will form an igneous rock with large crystals….What are igneous rocks like?ExtrusiveIntrusiveSize of crystalsSmallLargeExamplesObsidian and basaltGranite and gabbro2 more rows\nWhich minerals are found in igneous rocks?\nQuartz, calcite, and clay minerals are also common. Some minerals are more common in igneous rock (formed under extreme heat and pressure), such as olivine, feldspars, pyroxenes, and micas.\nHow can you tell the difference between intrusive and extrusive igneous rocks?\nExtrusive igneous rocks come from lava, forming at the surface of the Earth and cooling quickly, meaning they form very small crystals. Intrusive igneous rocks come from magma, forming deep underground and taking longer to cool, meaning they form larger crystals.\nWhat are 5 facts about igneous rocks?\nIgneous rocks are up!Igneous rocks are formed in molten magma.There are two types of igneous rock. … Igneous rock is also formed when magma cools and crystallises into a rock formation.Most of the earth’s crust is made out of igneous rock.Many mountains are made out of igneous rocks.Oct 20, 2012", "domain": "chemistry", "round": 3} +{"url": "http://www.antibodies-online.com/nf-kappab-signaling-pathway-5/irak4-elisa-kit-14047/", "date": "2018-01-20T11:22:28Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-05/segments/1516084889567.48/warc/CC-MAIN-20180120102905-20180120122905-00342.warc.gz", "language_score": 0.8659133315086365, "token_count": 1430, "dump": "CC-MAIN-2018-05", "global_id": "webtext-fineweb__CC-MAIN-2018-05__0__228929294", "lang": "en", "text": "Use your antibodies-online credentials, if available.\nNo Products on your Comparison List.\nYour basket is empty.\nFind out more\nShow all species\nShow all synonyms\nSelect your species\nData suggest that IRAK4 activity regulates activation of IRF5 (show IRF5 ELISA Kits), TAK1 (show MAP3K7 ELISA Kits), and IKKB (show IKBKB ELISA Kits) in monocytes; IRAK4 activation of TAK1 (show MAP3K7 ELISA Kits)-IKKB (show IKBKB ELISA Kits)-IRF5 (show IRF5 ELISA Kits) axis leads to induction of cytokines and interferons following TLR7 (show TLR7 ELISA Kits)/TLR8 (show TLR8 ELISA Kits) stimulation. (IRAK4 = interleukin-1 receptor-associated kinase 4; IRF5 (show IRF5 ELISA Kits) = interferon regulatory factor-5 (show IRF5 ELISA Kits); TAK1 (show MAP3K7 ELISA Kits) = MAPK (show MAPK1 ELISA Kits) kinase kinase 7; IKKB (show IKBKB ELISA Kits) = I-kappa B kinase; TLR = toll (show TLR4 ELISA Kits)-like receptor)\nAMPK (show PRKAA1 ELISA Kits) activation inhibited IL-1beta (show IL1B ELISA Kits)-stimulated CXCL10 (show CXCL10 ELISA Kits) secretion, associated with reduced interleukin-1 receptor associated kinase-4 (IRAK4) phosphorylation.\nBy CRISPR/Cas9-induced inactivation of TLR9 (show TLR9 ELISA Kits), MyD88 (show MYD88 ELISA Kits), IRAK4 and IRAK1 (show IRAK1 ELISA Kits) we confirm that BZLF1 repression is dependent on functional TLR9 (show TLR9 ELISA Kits) and MyD88 (show MYD88 ELISA Kits) signaling, and identify IRAK4 as an essential element for TLR9 (show TLR9 ELISA Kits)-induced repression of BZLF1 expression upon BCR (show BCR ELISA Kits) cross-linking\nthe polymorphisms in TLR-MyD88 (show MYD88 ELISA Kits)-NF-kappaB (show NFKB1 ELISA Kits) signaling pathway confer genetic susceptibility to Type 2 diabetes mellitus and diabetic nephropathy.\ndata show that in pericytes, MyD88 (show MYD88 ELISA Kits) and IRAK4 are key regulators of 2 major injury responses: inflammatory and fibrogenic.\nData suggest that, in monocytes and macrophages, the interleukin-1B- (IL1B (show IL1B ELISA Kits))-stimulated trans-autophosphorylation of IRAK4 is initiated by MYD88- (myeloid differentiation primary response gene 88 (show MYD88 ELISA Kits))-induced dimerization of IRAK4. In contrast, IRAK1 (interleukin-1 receptor-associated kinase 1 (show IRAK1 ELISA Kits)) is inactive in unstimulated monocytes/macrophages and is converted to an active protein kinase (show CDK7 ELISA Kits) in response to IL1B (show IL1B ELISA Kits).\nIRAK4 - Gene involved in innate immunity that have been associated with Chronic Rhinosinusitis.\nThe estimated prevalence of IRAK4 gene polymorphism found in a Portuguese Caucasian population was 26.8 % (CI 95%) [20.1, 34.7 %]. A model to predict the inflammatory response in the maxillary sinus in the presence etiological factors of dental origin was constructed.\nThis is the first study to show an association between single nucleotide polymorphisms in IRAK1 (show IRAK1 ELISA Kits), IRAK4 and MyD88 (show MYD88 ELISA Kits), and the presence of severe invasive pneumococcal disease.\nSrc (show SRC ELISA Kits), Syk (show SYK ELISA Kits), IRAK1 (show IRAK1 ELISA Kits), and IRAK4 have roles in anti-inflammatory responses mediated by dietary flavonoid Kaempferol\nIRAK4 kinase activity contributes to murine lupus and could represent a new therapeutic target.\nData demonstrate that IRAK-4 is essential for innate and adaptive immunity and necessary for efficient control of mycobacterial infections.\nSuppression of IRAK1 (show IRAK1 ELISA Kits) or IRAK4 Catalytic Activity, but Not Type 1 IFN Signaling, Prevents Lupus Nephritis in Mice Expressing a Ubiquitin Binding-Defective Mutant of ABIN1 (show TNIP1 ELISA Kits)\nPMA treatment during a vulnerable period can alter brain development. IL-18 and IRAK-4 appear to be important for the development of PMA induced injury.\nenforced expression of miR (show MLXIP ELISA Kits)-302b or IRAK4 siRNA silencing inhibits downstream NF-kappaB (show NFKB1 ELISA Kits) signalling and airway leukocyte infiltration, thereby alleviating lung injury and increasing survival in P. aeruginosa-infected mice.\nOur results demonstrate that osteoclasts and FBGCs are reciprocally regulated and identify IRAK4 as a potential therapeutic target to inhibit stimulated osteoclastogenesis and rescue inhibited FBGC formation\nSuggest FC-99 is a potential therapeutic molecule that alleviated experimental sepsis by directly inhibiting IRAK4 activation.\nMiR (show MLXIP ELISA Kits)-93 inhibits IRAK4 expression by binding directly to the 3'-UTR (show UTS2R ELISA Kits) of IRAK4.\nThis gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene.\ninterleukin-1 receptor-associated kinase 4\n, interleukin-1 receptor-associated kinase 4-like\n, Interleukin-1 receptor-associated kinase 4\n, renal carcinoma antigen NY-REN-64\n, NY-REN-64 antigen\n, interleukin-1 receptor associated kinase 4", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/ppp2r2a-antibody-ab197194.html", "date": "2020-08-11T13:06:35Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-34/segments/1596439738777.54/warc/CC-MAIN-20200811115957-20200811145957-00493.warc.gz", "language_score": 0.6835892200469971, "token_count": 628, "dump": "CC-MAIN-2020-34", "global_id": "webtext-fineweb__CC-MAIN-2020-34__0__96408758", "lang": "en", "text": "Key features and details\n- Rabbit polyclonal to PPP2R2A\n- Suitable for: IHC-P, WB\n- Reacts with: Human\n- Isotype: IgG\nProduct nameAnti-PPP2R2A antibody\nSee all PPP2R2A primary antibodies\nDescriptionRabbit polyclonal to PPP2R2A\nTested applicationsSuitable for: IHC-P, WBmore details\nSpecies reactivityReacts with: Human\nPredicted to work with: Mouse, Rat, Rabbit, Pig, Cynomolgus monkey\nRecombinant fragment corresponding to Human PPP2R2A aa 46-255. (BC041071).\nGDKGGRVVIFQQEQENKIQSHSRGEYNVYSTFQSHEPEFDYLKSLEIEEK INKIRWLPQKNAAQFLLSTNDKTIKLWKISERDKRPEGYNLKEEDGRYRD PTTVTTLRVPVFRPMDLMVEASPRRIFANAHTYHINSISINSDYETYLSA DDLRINLWHLEITDRSFNIVDIKPANMEELTEVITAAEFHPNSCNTFVYS SSKGTIRLCD\nDatabase link: P63151\n- HepG2 and Human fetal kidney lysates; Human fetal colon tissue.\nFormLyophilized:Reconstitute in 200ul sterile H2O.\nStorage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.\nStorage bufferpH: 7.20\nPreservative: 0.02% Sodium azide\nConstituents: 98% PBS, 1% BSA\nConcentration information loading...\nPurityImmunogen affinity purified\nOur Abpromise guarantee covers the use of ab197194 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\n|IHC-P||1/100 - 1/500.|\n|WB||1/1000 - 1/2000. Predicted molecular weight: 52 kDa.|\nFunctionThe B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.\nTissue specificityExpressed in all tissues examined.\nSequence similaritiesBelongs to the phosphatase 2A regulatory subunit B family.\nContains 7 WD repeats.\n- Information by UniProt\n- 2ABA_HUMAN antibody\n- Alpha isoform of regulatory subunit B55 protein phosphatase 2 antibody\n- B55A antibody\nab197194 has not yet been referenced specifically in any publications.", "domain": "chemistry", "round": 3} +{"url": "https://www.mdpi.com/2075-4701/7/10/398", "date": "2019-08-26T09:48:15Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-35/segments/1566027331485.43/warc/CC-MAIN-20190826085356-20190826111356-00521.warc.gz", "language_score": 0.924873948097229, "token_count": 397, "dump": "CC-MAIN-2019-35", "global_id": "webtext-fineweb__CC-MAIN-2019-35__0__1248868", "lang": "en", "text": "In this work, the microstructural evolutions and mechanical properties of an as-cast Mg-10Gd-4Y-1.5Zn-0.5Zr (wt %) alloy during successive multi-pass equal channel angular pressing (ECAP) were systematically investigated by X-ray diffractometer, scanning electron microscopy, transmission electron microscopy, and compression test. The obtained results show that the microstructure of as-cast alloy consists of α-Mg grains, Mg3\nGd island phase, few Y-rich particles, and lamellar 14H LPSO (long period stacking ordered) phase located at the grain boundaries. During ECAP, the Mg3\nGd-type phase is crushed and refined gradually. However, the refined Mg3\nGd particles are not distributed uniformly in the matrix, but still aggregated at the interdendritic area. The 14H phase becomes kinked during the early passes of ECAP and then broken at the kinking bands with more severe deformation. Dynamic recrystallization of α-Mg is activated during ECAP, and their average diameter decreases to around 1 μm, which is stabilized in spite of increasing ECAP passes. Moreover, nano-scale γ′ phases were dynamically precipitated in 16p ECAP alloy. Compression tests indicate that 16p ECAP alloy exhibits excellent mechanical property with compressive strength of 548 MPa and fracture strain of 19.1%. The significant improvement for both strength and ductility of deformed alloy could be ascribed to dynamic recrystallization (DRX) grains, refined Mg3\nGd-type and 14H particles, and dynamically precipitated γ′ plates.\nThis is an open access article distributed under the Creative Commons Attribution License\nwhich permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited", "domain": "chemistry", "round": 3} +{"url": "https://immuno-diffusion.com/en/2022/03/23/rumi-porc-test-2/", "date": "2022-12-08T02:26:30Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-49/segments/1669446711232.54/warc/CC-MAIN-20221208014204-20221208044204-00501.warc.gz", "language_score": 0.7245028018951416, "token_count": 272, "dump": "CC-MAIN-2022-49", "global_id": "webtext-fineweb__CC-MAIN-2022-49__0__189691116", "lang": "en", "text": "SRID kit for the control of the animal origin of the intestinal mucosa used to purify heparin\nThe principle of the test is based on the use of two different IDRing plates:\n– The IDRing plates RUMI Test that detect the presence of bovine, ovine and caprine tissues in the samples. The detection limit is 0.3% of ruminant intestinal mucosa in the pig intestinal mucosa.\n– The IDRing plates PORC Test that allows to certify the porcine intestinal mucosa origin and validates the analyze.\nThe kit consists of two IDRing Box:\n– IDRing box RUMI Test : 10 RUMI Test plates, 1 calibration set (enought for 100 RUMI Test)\n– IDRing PORC Test Box : 10 PORC Test plates, 1 calibration set (enought for 100 PORC Test), 1 vial of 30 ml of concentrated buffer for sample preparation.\nEach plate allows to analyze 5 samples of mucosa. A kit allows to analyze 50 samples.\n- Storage temperature: + 2° C to +8° C\n- Precautions: Do not freeze\n- Detection limit: 0.3% of mucosa from ruminant\n- Shelflife: 10 months from date of manufacture", "domain": "chemistry", "round": 3} +{"url": "https://newsexpress.ir/growing-things-how-to-tackle-blossom-end-rot-and-remove-slugs-from-the-garden/", "date": "2022-12-10T10:24:05Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-49/segments/1669446710421.14/warc/CC-MAIN-20221210074242-20221210104242-00594.warc.gz", "language_score": 0.949215292930603, "token_count": 373, "dump": "CC-MAIN-2022-49", "global_id": "webtext-fineweb__CC-MAIN-2022-49__0__187475131", "lang": "en", "text": "Article content continued\nThe plant needs calcium to develop fruit properly, and that calcium is dissolved in soil water. If water is lacking then so is the calcium. Thus, you can have a calcium deficiency and yet have a good source of calcium in the soil. You can test your soil to make sure you don’t have a calcium deficiency. Simple soil test kits are available in most garden centres.\nRapidly growing plants are more prone to the problem because fast growth requires an abundant supply of water and calcium. Also, excess nitrogen can contribute to the problem by excessively speeding up growth.\nTransplanting tomatoes into cold soil may also contribute to calcium deficiency because the organisms that convert calcium into a usable form are not as active in cold soils. Also, keep in mind that cultivating deeply around tomatoes can damage roots and cause a lack of water and calcium uptake.\nHere are some tips to avoid blossom end rot:\n– Keep soil moist but not sopping wet. Excess water is just as bad as not enough.\n– Mulching will help maintain even soil moisture.\n– Shallow, frequent cultivation is best.\n– Make sure to have an adequate, but not excessive, level of nitrogen.\nI have to share this e-mail I received:\n“You have written several columns on slugs, but I have never seen you mention actually catching them and disposing of these slimy creatures. The method I use is quick, clean, and easy. The best time to catch them is after a rain, early on a dewy morning, or later in the evening. I use my ‘super duper slug scooper’ (also known as a spoon, preferably a tablespoon) and scoop them up and put them in an empty yogurt container (other containers with a lid will also work).", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/recombinant-human-cd62l-protein-ab132972.html", "date": "2018-08-16T19:31:10Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-34/segments/1534221211167.1/warc/CC-MAIN-20180816191550-20180816211550-00328.warc.gz", "language_score": 0.6932355761528015, "token_count": 312, "dump": "CC-MAIN-2018-34", "global_id": "webtext-fineweb__CC-MAIN-2018-34__0__60076550", "lang": "en", "text": "The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\nProtein concentration is above or equal to 0.05 µg/µl.\nConcentration information loading...\nPreparation and Storage\nStability and Storage\nShipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.\npH: 8.00 Constituents: 0.31% Glutathione, 0.79% Tris HCl\nCD62 antigen ligand\nCD62 antigen-like family member L\nIgA nephropathy, susceptibility to, included\nLeukocyte adhesion molecule 1\nLeukocyte surface antigen Leu-8\nLeukocyte-endothelial cell adhesion molecule 1\nLymph node homing receptor\nLymphocyte adhesion molecule 1\nLymphocyte antigen 22\nLymphocyte surface MEL-14 antigen\nPln homing receptor\nCell surface adhesion protein. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia.\nExpressed in B cell lines and T lymphocytes.\nBelongs to the selectin/LECAM family. Contains 1 C-type lectin domain. Contains 1 EGF-like domain. Contains 2 Sushi (CCP/SCR) domains.", "domain": "chemistry", "round": 3} +{"url": "https://journals.ametsoc.org/view/journals/atot/30/2/jtech-d-12-00074_1.xml?tab_body=pdf", "date": "2021-01-20T17:30:36Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-04/segments/1610703521139.30/warc/CC-MAIN-20210120151257-20210120181257-00094.warc.gz", "language_score": 0.660142719745636, "token_count": 2086, "dump": "CC-MAIN-2021-04", "global_id": "webtext-fineweb__CC-MAIN-2021-04__0__273644792", "lang": "en", "text": "We thank Yann Bozec, for initial work on the mass spectrometer; Adam Cox, for assistance preparing gas cylinders; Todd Martz, for providing the optode; Yui Takeshita, for providing Winkler titration measurements; Roberta Hamme, for suggestions on ways to test the equilibrator; Mark Altabet for helpful discussions about building a gas tension device; and Angeline Ta, for help testing the gas tension device and equilibrator. We also thank three anonymous reviewers for their comments, which helped improve this manuscript. This material is based upon work supported by the National Science Foundation under Grant 0421546.\nAngert, A., , Rachmilevitch S. , , Barkan E. , , and Luz B. , 2003: Effects of photorespiration, the cytochrome pathway, and the alternative pathway on the triple isotopic composition of atmospheric O2. Global Biogeochem. Cycles, 17, 1030, doi:10.1029/2002GB001933.\nBender, M. L., 1990: The δ18O of dissolved O2 in seawater: A unique tracer of circulation and respiration in the deep sea. J. Geophys. Res., 95 (C12), 22 243–22 252.\nBender, M. L., , and Grande K. D. , 1987: Production, respiration, and the isotope geochemistry of O2 in the upper water column. Global Biogeochem. Cycles, 1, 49–59.\nBenson, B. B., , and Krause D. Jr., 1980: The concentration and isotopic fractionation of gases dissolved in freshwater in equilibrium with the atmosphere. 1. Oxygen. Limnol. Oceanogr., 25, 662–671.\nCassar, N., , Barnett B. A. , , Bender M. L. , , Kaiser J. , , Hamme R. C. , , and Tilbrook B. , 2009: Continuous high-frequency dissolved O2/Ar measurements by equilibrator inlet mass spectrometry. Anal. Chem., 81, 1855–1861.\nCopin-Montegut, C., 1985: A method for the continuous determination of the partial pressure of carbon dioxide in the upper ocean. Mar. Chem., 17, 13–21.\nEmerson, S., , Stump C. , , Wilbur D. , , and Quay P. , 1999: Accurate measurement of O2, N2 and Ar gases in water and the solubility of N2. Mar. Chem., 64, 337–347.\nFrankignoulle, M., , Borges A. , , and Biondo R. , 2001: A new design of equilibrator to monitor carbon dioxide in highly dynamic and turbid environments. Water Res., 35, 1344–1347.\nGuéguen, C., , and Tortell P. D. , 2008: High-resolution measurement of Southern Ocean CO2 and O2/Ar by membrane inlet mass spectrometry. Mar. Chem., 108, 184–194.\nHendricks, M. B., , Bender M. L. , , and Barnett B. A. , 2004: Net and gross O2 production in the Southern Ocean from measurements of biological O2 saturation and its triple isotope composition. Deep-Sea Res. I, 51, 1541–1561.\nJohnson, J. E., 1999: Evaluation of a seawater equilibrator for shipboard analysis of dissolved oceanic trace gases. Anal. Chim. Acta, 395, 119–132.\nJuranek, L. W., , and Quay P. D. , 2005: In vitro and in situ gross primary and net community production in the North Pacific Subtropical Gyre using labeled and natural abundance isotopes of dissolved O2. Global Biogeochem. Cycles, 19, GB3009, doi:10.1029/2004GB002384.\nKaiser, J., , Reuer M. K. , , Barnett B. , , and Bender M. L. , 2005: Marine productivity estimates from continuous O2/Ar ratio measurements by membrane inlet mass spectrometry. Geophys. Res. Lett., 32, L19605, doi:10.1029/2005GL023459.\nKeeling, R. F., , Blaine T. , , Paplawsky B. , , Katz L. , , Atwood C. , , and Brockwell T. , 2004: Measurement of changes in atmospheric Ar/N2 ratio using a rapid-switching, single-capillary mass spectrometer system. Tellus, 56B, 322–338.\nKnox, M., , Quay P. D. , , and Wilbur D. , 1992: Kinetic isotopic fractionation during air–water gas transfer of O2, N2, CH4, and H2. J. Geophys. Res., 97 (C12), 20 335–20 343.\nKörtzinger, A., , Thomas H. , , Schneider B. , , Gronau N. , , Mintrop L. , , and Duinker J. C. , 1996: At-sea intercomparison of two newly designed underway pCO2 systems—Encouraging results. Mar. Chem., 52, 133–145.\nLevine, N. M., , Bender M. L. , , and Doney S. C. , 2009: The δ18O of dissolved O2 as a tracer of mixing and respiration in the mesopelagic ocean. Global Biogeochem. Cycles, 23, GB1006, doi:10.1029/2007GB003162.\nLuz, B., , and Barkan E. , 2000: Assessment of oceanic productivity with the triple-isotope composition of dissolved oxygen. Science, 288, 2028–2031.\nMcNeil, C., , Katz D. , , Wanninkhof R. , , and Johnson B. , 2005: Continuous shipboard sampling of gas tension, oxygen and nitrogen. Deep-Sea Res. I, 52, 1767–1785.\nMcNeil, C., , D’Asaro E. , , Johnson B. , , and Horn M. , 2006: A gas tension device with response times of minutes. J. Atmos. Oceanic Technol., 23, 1539–1558.\nMurphy, P. P., , Nojiri Y. , , Fujinuma Y. , , Wong C. S. , , Zeng J. , , Kimoto T. , , and Kimoto H. , 2001: Measurements of surface seawater fCO2 from volunteer commercial ships: Techniques and experiences from Skaugran. J. Atmos. Oceanic Technol., 18, 1719–1734.\nQuay, P. D., , Emerson S. , , Wilbur D. O. , , and Stump C. , 1993: The δ18O of dissolved O2 in the surface waters of the subarctic Pacific: A tracer of biological productivity. J. Geophys. Res., 98 (C5), 8447–8458.\nQuiñones-Rivera, Z. J., , Wissel B. , , Justić D. , , and Fry B. , 2007: Partitioning oxygen sources and sinks in a stratified, eutrophic coastal ecosystem using stable oxygen isotopes. Mar. Ecol. Prog. Ser., 342, 69–83.\nReuer, M. K., , Barnett B. A. , , Bender M. L. , , Falkowski P. G. , , and Hendricks M. B. , 2007: New estimates of Southern Ocean biological production rates from O2/Ar ratios and the triple isotope composition of O2. Deep-Sea Res. I, 54, 951–974.\nSarma, V. V. S. S., , Abe O. , , Hashimoto S. , , Hinuma A. , , and Saino T. , 2005: Seasonal variations in triple oxygen isotopes and gross oxygen production in the Sagami Bay, central Japan. Limnol. Oceanogr., 50, 544–552.\nSchneider, B., , Kremling K. , , and Duinker J. C. , 1992: CO2 partial pressure in northeast Atlantic and adjacent shelf water: Processes and seasonal variability. J. Mar. Syst., 3, 453–463.\nSchneider, B., , Sadkowiak B. , , and Wachholz F. , 2007: A new method for continuous measurements of O2 in surface water in combination with pCO2 measurements: Implications for gas phase equilibration. Mar. Chem., 103, 163–171.\nStanley, R. H. R., , Kirkpatrick J. B. , , Cassar N. , , Barnett B. A. , , and Bender M. L. , 2010: Net community production and gross primary production rates in the western equatorial Pacific. Global Biogeochem. Cycles, 24, GB4001, doi:10.1029/2009GB003651.\nThiemens, M. H., , Jackson T. , , Zipf E. C. , , Erdman P. W. , , and van Egmond C. , 1995: Carbon dioxide and oxygen isotope anomalies in the mesosphere and stratosphere. Science, 270, 969–972.\nTortell, P. D., 2005: Dissolved gas measurements in oceanic waters made by membrane inlet mass spectrometry. Limnol. Oceanogr. Methods, 3, 24–37.", "domain": "chemistry", "round": 3} +{"url": "http://wordinfo.info/results/aquae", "date": "2017-04-29T23:23:06Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-17/segments/1492917123632.58/warc/CC-MAIN-20170423031203-00323-ip-10-145-167-34.ec2.internal.warc.gz", "language_score": 0.8281018733978271, "token_count": 286, "dump": "CC-MAIN-2017-17", "global_id": "webtext-fineweb__CC-MAIN-2017-17__0__208522782", "lang": "en", "text": "2. A liquid solution; especially, in water.\n3. A light bluish green to light greenish blue; also, greenish blue, turquoise, cobalt blue, and peacock blue.\nWater, taken in moderation, cannot hurt anybody.\nA reference to an aqueduct that was used to supply water to the city of Rome. During the Republic, aqueducts, and the water supplied, were cared for by water companies hired under contract by the censors.\nThis abbreviation (aq.) is used with several adjectives that have applications for medical or pharmaceutical instructions:\n- aq. astr. (aqua astricta), frozen water\n- aq. bull. (aqua bulliens), boiling water\n- aq. com. (aqua communis), common water\n- aq. dest. (aqua destillata), distilled water\n- aq. ferv. (aqua fervens), hot water\n- aq. frig. (aqua frigida), cold water\n- aq. mar. (aqua marina), sea water\n- aq. pluv. (aqua pluvialis), rain water\n- aq. pur. (aqua pura), pure water\n- aq. tep. (aqua tepida), tepid water", "domain": "chemistry", "round": 3} +{"url": "https://www.creative-diagnostics.com/Anti-Epstein-Barr-Virus-Nuclear-Antigen-Antibody-54676-144.htm", "date": "2019-02-21T14:42:02Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-09/segments/1550247504790.66/warc/CC-MAIN-20190221132217-20190221154217-00053.warc.gz", "language_score": 0.7352545261383057, "token_count": 335, "dump": "CC-MAIN-2019-09", "global_id": "webtext-fineweb__CC-MAIN-2019-09__0__32775371", "lang": "en", "text": "Anti-EBV Nuclear antigen Monoclonal antibody (DMABT-51238ME)\nMouse Anti-EBV Nuclear antigen Monoclonal antibody for IHC, ELISA, FC, IP, WB\nBring this labeled antibody directly to your bench!\nAdd to basket\nLymphocryptovirus; Herpesviridae; EBV; Epstein Barr Virus\nHave you cited DMABT-51238ME in a publication? Let us know\nand earn a reward for your research.\nIncaprera, M; Rindi, L; et al. Potential role of the Epstein-Barr virus in systemic lupus erythematosus autoimmunity. CLINICAL AND EXPERIMENTAL RHEUMATOLOGY 16:289-294(1998).\nHarada, S; Obayashi, M; et al. A monoclonal antibody that recognizes Epstein-Barr virus nuclear antigen 2 (EBNA 2) amino acids 1-58 does not react with EBNA 2 in native form, consistent with the self-association of EBNA 2 through the amino-terminus. ARCHIVES OF VIROLOGY 150:1033-1043(2005).\nCustom Antibody Labeling\nWe offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody.", "domain": "chemistry", "round": 3} +{"url": "https://www.confer.cz/nanocon/2017/350-influence-of-liposomal-platinum-cytostatics-on-cancer-cells-by-voltammetric-methods", "date": "2023-09-28T18:17:04Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233510427.16/warc/CC-MAIN-20230928162907-20230928192907-00487.warc.gz", "language_score": 0.9356883764266968, "token_count": 314, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__250510543", "lang": "en", "text": "Aim of this work deals with closing of cisplatin into liposomes, the study of their stability and interaction with cancer cell lines. Commercial cisplatin cytostatic was encapsulated into three types of liposomes (L8, L10 and L15) of a different chemical composition. Each of liposomes had different ability to close cytostatic. L8 differs from L10 by containing cholesterol. In despite of L10 and L8, L15 liposome contains a synthetic 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (C41H78NO8P) – DOPE, which is generally found in cell membranes. The size of the liposomes was characterized by Dynamic Light Scattering (DLS). The amount of Pt-drug in liposomes was verified by electrochemical determination. Their stability was observed by differential pulse voltammetry (DPV). These studies also demonstrated, that the cisplatin is stable in physiological solution for at least 24 hours, which making it a suitable medium storage for this drug. Finally, the encapsulated cisplatin was applied to cancer cell lines and their viability was observed by MTT assay.Keywords: Cisplatin, liposomes, electrochemistry, differential pulse voltammetry, cancer cell lines,\n© This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.", "domain": "chemistry", "round": 3} +{"url": "https://figshare.com/articles/ELISA_measurements_for__Multi-omic_profiles_of_human_non-alcoholic_fatty_liver_disease_tissue_highlight_heterogeneity_in_disease_phenotype_/1558258/1", "date": "2018-12-13T15:10:48Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-51/segments/1544376824912.16/warc/CC-MAIN-20181213145807-20181213171307-00250.warc.gz", "language_score": 0.8875092267990112, "token_count": 256, "dump": "CC-MAIN-2018-51", "global_id": "webtext-fineweb__CC-MAIN-2018-51__0__75660612", "lang": "en", "text": "ELISA measurements for \"Multi-omic profiles of human non-alcoholic fatty liver disease tissue highlight heterogeneity in disease phenotype\"\n2015-12-08T18:49:09Z (GMT) by\n

ELISA measurements from plasma samples were carried out using the Ciraplex® platform (Aushon Biosystems, Billerica, MA, US). Commercial assays were purchased and measurements were carried out according to instructions provided by the manufacturer. The following 29 targets were analyzed either as single-plex assays or as multiplex assay: hFGFb; hGROa; hLIF;hIFNg; hIL1b; IL4; IL5; hIL6; hIL10; hIL12p70; hIL13; hTNFa; hI309; hIL8; hIP10; hMCP4; hMIP1a; hMIP1b; hCRP; hLeptin; hPAIactive; hResistin; hIGFBP1; hIGFBP3; hIGFBP2; hMIF; hApoA1; hCRP; hAcrp30.

", "domain": "chemistry", "round": 3} +{"url": "https://en.parfumdreams.de/Prada/Womens-fragrances/La-Femme-Prada/Eau-de-Parfum-Spray/index_67535.aspx", "date": "2021-09-28T17:38:32Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-39/segments/1631780060877.21/warc/CC-MAIN-20210928153533-20210928183533-00211.warc.gz", "language_score": 0.7124369144439697, "token_count": 345, "dump": "CC-MAIN-2021-39", "global_id": "webtext-fineweb__CC-MAIN-2021-39__0__34798158", "lang": "en", "text": "Customers also bought\nDescription by La Femme Prada Eau de Parfum Spray Intense by Prada\nLa Femme Prada Intense is an Eau de Parfum with a sultry, almost oriental quality, which exudes a heady sensuality. The intensity of the fragrance is achieved by magnifying the Tuberose, Ylang-Ylang and Patchouli at the heart of its composition.\nContents by La Femme Prada Eau de Parfum Spray Intense by Prada\nALCOHOL DENAT.,ACQUA (WATER), PARFUM (FRAGRANCE),BENZYL SALICYLATE,LINALOOL, ETHYLHEXYL METHOXYCINNAMATE, HEXYL CINNAMAL, CITRONELLOL, HYDROXYCITRONELLAL,LIMONENE, GERANIOL, BUTYL METHOXYDIBENZOYLMETHANE,ETHYLHEXYL SALICYLATE, BENZYL BENZONATE, COUMARIN, EUGENOL, FARNESOL, ISOEUGENOL, BENZYL CINNAMATE, BENZYL ALCOHOL, CINNAMYL ALCOHOL, CITRAL, CINNAMAL, CI 60730 (EXT. VIOLET 2), CI 147700 (Red 4), CI 17200 (Red33), CI 19140 (YELLOW 5), CI 42090 (BLUE 1) ALCOHOL OF VEGETAL ORIGIN 80%", "domain": "chemistry", "round": 3} +{"url": "https://iovs.arvojournals.org/article.aspx?articleid=2407973", "date": "2018-08-15T05:44:34Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-34/segments/1534221209884.38/warc/CC-MAIN-20180815043905-20180815063905-00331.warc.gz", "language_score": 0.903189480304718, "token_count": 491, "dump": "CC-MAIN-2018-34", "global_id": "webtext-fineweb__CC-MAIN-2018-34__0__55024883", "lang": "en", "text": "Purchase this article with an account.\nM.A. Swiatek–De Lange, M. Ueffing; Functional Analysis of Membrane–bound Protein Complexes from Mammalian Photoreceptors. . Invest. Ophthalmol. Vis. Sci. 2004;45(13):2433.\nDownload citation file:\n© ARVO (1962-2015); The Authors (2016-present)\nPurpose:To isolate and characterize the dynamics of membrane–bound multiprotein complexes in mammalian photoreceptors. Methods:Mammalian photoreceptor outer segments (POS) were isolated from porcine retinae. In order to increase both the efficiency and purity of POS preparation, we compared two standard isolation protocols with samples pre–fractionated by Free Flow Electrophoresis (FFE) and with purified disk membranes. The membranous POS fraction was solubilized with mild detergent and native protein complexes were separated using density gradient centrifugation or Blue Native Gel Electrophoresis. Individual proteins were separated by SDS–PAGE and identified by MALDI–TOF mass spectrometry. Results:The separation of membrane–associated proteins by means of traditional 2–DE methodology has been greatly difficult. Moreover, the denaturing conditions underlying 2–DE prevent isolation of functional protein complexes. Our experiments have therefore combined traditional biochemical native separation methods and improved solubilization and separation conditions to optimize the isolation of stable multiprotein complexes from mammalian photoreceptor outer segments. Initial analysis of crude POS demonstrated high complexity and impurity of the preparations, e.g. sample contamination by protein complexes characteristic for photoreceptor inner segments (phosducin and 14–3–3 proteins). Preparation of intact disk membranes or POS pre–fractionation by FFE greatly reduced complexity and increased sample purity. Using a proteomic approach, we have identified several candidates as novel components of the phototransduction pathway, including small GTPases from Rho and Rab families, and established a preliminary protein interaction map for mammalian photoreceptors. Conclusions:We have detected protein interactions linked to the physiology of vision in mammalian photoreceptors. Protein interaction maps and analysis of their dynamics can be correlated to physiological states and will be used for a better understanding of vision processes and their pathology in diseases causing blindness.\nThis PDF is available to Subscribers Only", "domain": "chemistry", "round": 3} +{"url": "https://www.creative-diagnostics.com/Anti-Influenza-A-H5-Antigen-Antibody-54749-144.htm", "date": "2018-11-15T04:06:34Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-47/segments/1542039742483.3/warc/CC-MAIN-20181115033911-20181115055911-00327.warc.gz", "language_score": 0.6914312839508057, "token_count": 340, "dump": "CC-MAIN-2018-47", "global_id": "webtext-fineweb__CC-MAIN-2018-47__0__169584653", "lang": "en", "text": "Anti-IAV H5N1 Monoclonal antibody (DMABT-51388MI)\nMouse Anti-IAV H5N1 Monoclonal antibody for IHC, ELISA, FC, FuncS, IP, WB\nBring this labeled antibody directly to your bench!\nOnline Inquiry Add to basket\nPurified avian influenza virus type A (H5N1)\nInfluenza A Hemagglutinin; Influenza A; H5N1; ha; HA1; HA2\nHave you cited DMABT-51388MI in a publication? Let us know\nand earn a reward for your research.\nDu, LY; Li, Y; et al. Potential strategies and biosafety protocols used for dual-use research on highly pathogenic influenza viruses. REVIEWS IN MEDICAL VIROLOGY 22:412-419(2012).\nKhazeni, N; Hutton, DW; et al. Effectiveness and Cost-Effectiveness of Expanded Antiviral Prophylaxis and Adjuvanted Vaccination Strategies for an Influenza A (H5N1) Pandemic. ANNALS OF INTERNAL MEDICINE 151:840-U3(2009).\nCustom Antibody Labeling\nWe offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody.", "domain": "chemistry", "round": 3} +{"url": "https://standards.globalspec.com/standards/detail?docId=14205158", "date": "2021-05-15T18:44:53Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-21/segments/1620243990551.51/warc/CC-MAIN-20210515161657-20210515191657-00361.warc.gz", "language_score": 0.9074806571006775, "token_count": 307, "dump": "CC-MAIN-2021-21", "global_id": "webtext-fineweb__CC-MAIN-2021-21__0__198428762", "lang": "en", "text": "Standard Specification for Fly Ash and Other Pozzolans for Use With Lime for Soil Stabilization\n|Publication Date:||1 December 2019|\n|ICS Code (Cement. Gypsum. Lime. Mortar):||91.100.10|\nThis specification covers the qualification of fly ash and other pozzolans for use with lime in plastic, nonplastic mixtures and other mixtures that affect lime pozzolanic reaction required by soil stabilization. Evaluation of pozzolans containing available lime, such as Class C fly ash, is given consideration. Pozzolans covered include artificial pozzolans such as fly ash, and natural pozzolans, such as diatomite and pumicite, in either raw or calcined state.\nThe values stated in SI units are to be regarded as standard. No other units of measurement are included in this standard.\nThis standard does not purport to address all of the safety concerns, if any, associated with its use. It is the responsibility of the user of this standard to establish appropriate safety, health, and environmental practices and determine the applicability of regulatory limitations prior to use.\nThis international standard was developed in accordance with internationally recognized principles on standardization established in the Decision on Principles for the Development of International Standards, Guides and Recommendations issued by the World Trade Organization Technical Barriers to Trade (TBT) Committee.\n*A Summary of Changes section appears at the end of this standard", "domain": "chemistry", "round": 3} +{"url": "http://www.bioinf.org/2019/05/08/history-and-purpose-the-naca2-exchanger-is-a-bi-directional-transporter-that/", "date": "2023-10-03T03:50:33Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233511053.67/warc/CC-MAIN-20231003024646-20231003054646-00349.warc.gz", "language_score": 0.9244841933250427, "token_count": 1358, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__300720459", "lang": "en", "text": "History AND PURPOSE The Na+/Ca2+ exchanger is a bi-directional transporter that plays a significant role in maintaining the concentration of cytosolic Ca2+ ([Ca2+]i) of quiescent platelets and increasing it during activation with some, however, not all, agonists. Essential RESULTS Individual platelets exhibit NCX1.3, NCX3.2 and NCX3.4. The NCXs work buy 83-49-8 in the Ca2+ efflux setting in relaxing platelets and in addition throughout their activation with thrombin however, not collagen. Collagen-induced upsurge in [Ca2+]i was decreased using the pharmacological inhibitors of NCX (CBDMB, KB-R7943 or Ocean0400), anti-NCX1 and anti-NCX3. On the other hand, anti-NCKX1 improved the collagen-induced upsurge in [Ca2+]i. CONCLUSIONS AND IMPLICATIONS Individual platelets exhibit K+-unbiased Na+/Ca2+ exchangers NCX1.3, NCX3.2 and NCX3.4. During collagen activation, NCX1 and NCX3 transiently invert to market Ca2+ influx, whereas NCKX1 proceeds to use in the Ca2+ efflux setting to lessen [Ca2+]i. (Alexander for 15 min, and platelets had been isolated in the platelet-rich plasma by centrifugation at 800 x for 15 min. Platelet examples had been re-suspended in 500 L of platelet-poor plasma. For the calcium mineral studies, samples had been packed with calcium-sensitive fluorescent dye, calcium-green (10 M) and fura-red (20 M) regarding to previously released methods (Roberts for 15 min. The supernatant was after that filtered through a mozzarella cheese material, incubated on glaciers SPTAN1 for 15 min with identical level of buy 83-49-8 1 M KCl and centrifuged at 100 000for 30 min. The pellet attained was re-suspended in TED and centrifuged at 100 000for 30 min. The ultimate pellet was after that suspended in BRIJ lysis buffer. Immunoblotting Protein had been used in a nitrocellulose membrane (100 V for 90 min) after electrophoretic parting. nonspecific binding sites had been obstructed, by rocking the nitrocellulose membranes in 5% (w/v) BSA in Tris-buffered saline with 0.05% Tween (TBS-T) at room temperature for 3 h. The membranes had been incubated with principal antibodies particular for NCX1 (polyclonal rabbit anti-rat antibody; dilution 1:1000 in 1% BSA TBS-T), NCX3 (polyclonal rabbit anti-rat antibody; dilution 1:1000 in 1% BSA TBS-T) or NCKX1 (polyclonal rabbit anti-human antibody; dilution 1:500 in 1% BSA TBS-T) right away at 4C. buy 83-49-8 The nitrocellulose membranes had been incubated with peroxidase-conjugated supplementary antibody (dilution: 1:5000 in 1% BSA TBS-T). Recognition from the peroxidase response was performed using the improved chemiluminescence assay (Amersham Biosciences, Piscataway, NJ). Computation of price of drop in [Ca2+]i Primary Ca2+ tracings had been digitized using a Houston Equipment (Austin, TX, USA) digitizing tablet as well as the ratios of fluorescence at 540/660 nm had been plotted versus period. The ASYST edition 3.0 computer system (Mcmillan Software program Co., NY, NY) was utilized to execute compartmental evaluation (curve peeling), which solved the drop in [Ca2+]we following collagen-induced top upsurge in [Ca2+]we into two stages with different kinetics. Calcium mineral uptake and efflux was computed being a % transformation (min-1) using the top collagen-induced upsurge in [Ca2+]i used as the utmost. Statistical evaluation All data are portrayed as mean SEM. denotes the amount of participants (bloodstream donors) from whom the platelets had been attained. anova was employed for obstructed evaluations. 0.05 buy 83-49-8 was taken as significant. Outcomes Evaluation of mRNA appearance by PCR Within this study, we’ve determined if individual platelets exhibit the K+-indie kind of Na+/Ca2+ exchanger mRNA and discovered the precise isoforms. Because of the high amount of series homology among the three associates of this category of exchangers, primers had been chosen to tell apart between not merely the three types but also to look for the particular isoforms. Total RNA was extracted from individual platelets, and RT-PCR was performed using primers particular to NCX1, NCX2 and NCX3. This response yielded items for NCX1 and NCX3 that might be visualized within an ethidium bromide agarose gel. No rings had been noticed for NCX2. The NCX1 music group of 438 bottom pairs (bp) was sequenced to verify its identification as NCX1.3 (Body 1A). The primers selected for NCX3 yielded a solid music group of 512 bp and a faint music group of 412 bp (Body 1A). Sequencing of the PCR products verified the identification as NCX3.2 and NCX3.4, respectively. Open up in another window Body 1 Characterization from the individual platelet Na+/Ca2+ exchangers. (A) NCX mRNA appearance by PCR. PCR items from individual platelets loaded on the 1.2% agarose gel containing ethidium bromide: GAPDH (1), NCX1 (2), NCX2 (3), NCX3 (4). (B) Real-time quantitative PCR for NCX1.3, NCX3.2, NCX3.4 and NCKX1 appearance. Quantitative PCR of cDNA equal to 5 ng of total RNA extracted from individual platelets was performed by monitoring the constant deposition of SYBR.", "domain": "chemistry", "round": 3} +{"url": "https://upcommons.upc.edu/browse?value=B%C3%B6rzs%C3%B6nyi,%20T&type=author", "date": "2021-07-24T05:51:12Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-31/segments/1627046150129.50/warc/CC-MAIN-20210724032221-20210724062221-00641.warc.gz", "language_score": 0.7550337910652161, "token_count": 282, "dump": "CC-MAIN-2021-31", "global_id": "webtext-fineweb__CC-MAIN-2021-31__0__240063208", "lang": "en", "text": "Browsing by Author \"Börzsönyi, T\"\nHeat diffusion anisotropy in dendritic growth: phase field simulations and experiments in liquid crystals González Cinca, Ricardo; Ramírez de la Piscina Millán, Laureano; Casademunt Viader, Jaume; Hernández Machado, Aurora; Toth-Katona, T; Börzsönyi, T; Buka, A (1998-10)\nRestricted access - publisher's policyAn anisotropic heat diffusion coefficient is introduced in order to study some interfacial growth phenomena. This anisotropy has been incorporated in a phase field model which has been studied numerically to reproduce some ...\nToth-Katona, T; Börzsönyi, T; Buka, A; González Cinca, Ricardo; Ramírez de la Piscina Millán, Laureano; Casademunt Viader, Jaume; Hernández-Manchado, A; Kramer, L (2000-10)\nRestricted access - publisher's policyFree growth properties of the smectic B liquid crystalline phase into the supercooled nematic have been investigated in quasi-two-dimensional geometry. Different orientation combinations of the two phases have been achieved ...", "domain": "chemistry", "round": 3} +{"url": "https://yomrishon.org/library/absorbent-technology-textile-science-and-technology", "date": "2019-10-23T18:54:17Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-43/segments/1570987835748.66/warc/CC-MAIN-20191023173708-20191023201208-00202.warc.gz", "language_score": 0.9082656502723694, "token_count": 506, "dump": "CC-MAIN-2019-43", "global_id": "webtext-fineweb__CC-MAIN-2019-43__0__212600099", "lang": "en", "text": "By P. K. Chatterjee,B. S. Gupta\nRead or Download Absorbent Technology (Textile Science and Technology) PDF\nBest textiles & polymers books\nPolyolefins are the main conventional advertisement polymers and their functionalization has been an extended status clinical problem and an industrially very important region. In contemporary a long time major growth has been made within the sector, with intriguing effects mentioned in lots of journals. Functionalization of Polyolefins is the 1st booklet to summarize the numerous experimental effects at the functionalization of polyolefins and classify them into numerous chemical equipment (shown in each one bankruptcy of this book).\nQuantity A of instruction manual of Polymer Nanocomposites offers with Layered Silicates. In a few 20 chapters the instruction, structure, characterisation, houses and alertness of polymer nanocomposites are mentioned by means of specialists of their respective fields\nLianwei Li's Ph. D. thesis solves a long-standing challenge in polymer physics: how does a hyperbranched chain go through a cylindrical pore smaller than its measurement below an elongational movement box? The query was once requested through the Nobel Laureate, the overdue Professor de Gennes within the 70s yet hasn't ever been heavily addressed via actual experiments.\nThis quantity provides the papers from the 7th North-European Symposium for Archaeological Textiles (NESAT), held in Edinburgh in 1999. the topics coated reveal various scholarship that would inspire someone operating during this vital and stimulating sector of archaeology. From the golden gowns of a Roman burial, to the modern Viking in Denmark, via to the early glossy interval and extra technological points of textile-research, those twenty-four papers (five of that are in German) offer a wealth of recent details at the research of historic textiles in northern Europe.\n- Principles of Polymer Processing\n- Ethnic Fashion (Environmental Footprints and Eco-design of Products and Processes)\n- From Single Molecules to Nanoscopically Structured Materials (Advances in Polymer Science)\n- Polymer Crystallization II: From Chain Microstructure to Processing (Advances in Polymer Science)\n- Advanced Polymer Processing Operations\nAdditional info for Absorbent Technology (Textile Science and Technology)\n- Small States in the European Union by Diana Panke\n- Friction in Textile Materials (Woodhead Publishing Series in by B S Gupta", "domain": "chemistry", "round": 3} +{"url": "https://pogustgoodhead.com/us/pennsylvania-marches-towards-enacting-state-drinking-water-standards-for-toxic-pfoa-and-pfos/", "date": "2023-05-30T20:30:04Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-23/segments/1685224646144.69/warc/CC-MAIN-20230530194919-20230530224919-00244.warc.gz", "language_score": 0.9272388219833374, "token_count": 753, "dump": "CC-MAIN-2023-23", "global_id": "webtext-fineweb__CC-MAIN-2023-23__0__1251714", "lang": "en", "text": "Author: Daniel J. Harrison, Esq.\nThe Pennsylvania Department of Environmental Protection (PADEP) recently proposed a new regulation that would set maximum contaminant levels for two types of toxic per-and poly-fluoroalkyl substances (PFAS) —18 parts per trillion (ppt) for perfluorooctane sulfonic acid (PFOS) and 14 ppt for perfluorooctanoic acid (PFOA).\nThe proposed standards follow Executive Order 2018-18 signed by Governor Tom Wolf in September 2018, which created Pennsylvania’s PFAS Action Team.\nGov. Wolf instructed the PFAS Action Team, a multi-agency group, to:\n– Identify impacted natural resources;\n– Create plans to assist state and local authorities and public water systems with delivering safe drinking water;\n– Manage PFAS contamination;\n– Develop and implement environmental response protocols for all positively identified sites; develop specialized site plans, engaging the public and other relevant stakeholders when appropriate;\n– Reduce risks to drinking water and the environment from sources of PFAS;\n– Identify PFAS uses that are most likely to pose a risk to human health and the environment;\n– Develop recommendations and actions that can be taken to limit or control these sources of PFAS;\n– Develop a clearinghouse of information on PFAS and establish a public information site;\n– Explore avenues of funding for remediation efforts; and\n– Engage academic institutions and experts in the field when necessary.\nAs a result, the PADEP began its investigation to determine the extent of any PFAS contamination inside the Commonwealth in 2019 and concluded that 493 public water systems are located within a half-mile of potential PFAS sources.\nPADEP subsequently collected two rounds of selective sampling from public water supplies and released their results in March and June 2021, respectively. The results showed that about one-third of Pennsylvania water systems contain PFAS, including dozens of sites that showed levels of toxic PFOS and PFOA and levels of other types of PFAS that have not yet been widely studied.\nNow, PADEP proposes regulations to set drinking water standards for at least PFOA and PFOS as numerous studies have established links between PFOA and PFOS exposure and a wide range of severe health effects, including increased risks of cancer, thyroid disease, high cholesterol, liver damage, kidney disease, low birth-weight babies, immune suppression, ulcerative colitis, and pregnancy-induced hypertension.\nIf adopted, these regulations would ensure Pennsylvanians have access to clean water and can be used to hold polluters accountable for discharging PFOA and PFOS throughout the Commonwealth. The comment period for these drinking water standards is currently open but will expire on April 25, 2022.\nComments may be submitted to the Environmental Quality Board through PADEP’s eComment system at http://www.ahs.dep.pa.gov/eComment.\nComments may also be submitted via e-mail at [email protected]. Each comment must include a subject heading of the proposed rulemaking and the name and address of the person submitting the comment. Written comments may be mailed to the Environmental Quality Board, P.O. Box 8477, Harrisburg, PA 17105-8477.", "domain": "chemistry", "round": 3} +{"url": "http://scitation.aip.org/content/aip/journal/apl/92/26/10.1063/1.2955516", "date": "2015-10-09T20:12:34Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2015-40/segments/1443737935292.75/warc/CC-MAIN-20151001221855-00224-ip-10-137-6-227.ec2.internal.warc.gz", "language_score": 0.6940196752548218, "token_count": 657, "dump": "CC-MAIN-2015-40", "global_id": "webtext-fineweb__CC-MAIN-2015-40__0__129201343", "lang": "en", "text": "No data available.\nPlease log in to see this content.\nYou have no subscription access to this content.\nNo metrics data to plot.\nThe attempt to load metrics for this article has failed.\nThe attempt to plot a graph for these metrics has failed.\nThe full text of this article is not currently available.\nCesium hydroxide doped tris-(8-hydroxyquinoline) aluminum as an effective electron injection layer in inverted bottom-emission organic light emitting diodes\n1.X. Zhou, M. Pfeiffer, J. S. Huang, J. Blochwitz-Nimoth, D. S. Qin, A. Werner, J. Drechesel, B. Maennig, and K. Leo, Appl. Phys. Lett. 81, 922 (2002).\n5.T. Dobbertin, O. Werner, J. Meyer, A. Kammoun, D. Schneider, T. Riedl, E. Becker, H. H. Johannes, and W. Kowalsky, Appl. Phys. Lett. 83, 5071 (2003).\n6.J. M. Zhao, Y. Q. Zhan, S. T. Zhang, X. J. Wang, Y. C. Zhou, Y. Wu, Z. J. Wang, X. M. Ding, and X. Y. Hou, Appl. Phys. Lett. 84, 5377 (2004).\n7.L. S. Liao, L. S. Hung, W. C. Chan, X. M. Ding, T. K. Sham, I. Bello, C. S. Lee, and S. T. Lee, Appl. Phys. Lett. 75, 1619 (1999).\n15.A. Band, A. Albu-Yaron, T. Livneh, H. Cohen, Y. Feldman, L. Shimon, R. Popovitz-Biro, V. Lyahovitskaya, and R. Tenne, J. Phys. Chem. B 108, 12360 (2004).\n17.F. Wang, T. Xiong, X. Qiao, and D. Ma (unpublished).\nArticle metrics loading...\nWe demonstrate highly efficient inverted bottom-emission organic light-emitting diodes (IBOLEDs) by using cesium hydroxide (CsOH) doped tris-(8-hydroxyquinoline) aluminum as the electron injection layer on indium tin oxide cathode, which could significantly enhance the electron injection, resulting in a large increase in luminance and efficiency. The maximum luminance, current efficiency, and power efficiency reach , , and , respectively, which are 40%–50% higher in efficiency than that of IBOLEDs with cesium carbonate doped as the electron injection layer, where the efficiencies are only and . Our results indicate that CsOH doped should be an effective electron injection layer on a wide range of electrodes to fabricate high performance OLEDs.\nFull text loading...\nMost read this month", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/usp20-antibody-ab72225.html", "date": "2020-09-18T14:20:54Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-40/segments/1600400187899.11/warc/CC-MAIN-20200918124116-20200918154116-00119.warc.gz", "language_score": 0.7530790567398071, "token_count": 1001, "dump": "CC-MAIN-2020-40", "global_id": "webtext-fineweb__CC-MAIN-2020-40__0__107149270", "lang": "en", "text": "Key features and details\n- Rabbit polyclonal to USP20\n- Suitable for: WB, IP\n- Reacts with: Mouse, Human\n- Isotype: IgG\nProduct nameAnti-USP20 antibody\nSee all USP20 primary antibodies\nDescriptionRabbit polyclonal to USP20\nTested applicationsSuitable for: WB, IPmore details\nSpecies reactivityReacts with: Mouse, Human\nPredicted to work with: Rabbit, Horse, Chicken, Dog, Pig, Chimpanzee, Rhesus monkey, Gorilla, Chinese hamster, Orangutan, Elephant\nSynthetic peptide corresponding to a region between residues 863 and 913 of human USP20 (NP_006667.2).\nStorage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.\nStorage bufferpH: 7\nPreservative: 0.09% Sodium azide\nConstituents: 0.1% BSA, Tris buffered saline\nConcentration information loading...\nPurityImmunogen affinity purified\nOur Abpromise guarantee covers the use of ab72225 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\n|WB||1/2000 - 1/10000. Detects a band of approximately 120 kDa (predicted molecular weight: 102 kDa).|\n|IP||Use at 2-5 µg/mg of lysate.|\nFunctionDeubiquitinating enzyme involved in beta-2 adrenergic receptor (ADRB2) recycling. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.\nSequence similaritiesBelongs to the peptidase C19 family. USP20/USP33 subfamily.\nContains 2 DUSP domains.\nContains 1 UBP-type zinc finger.\nDomainThe UBP-type zinc finger binds 3 zinc ions. However, it does not bind ubiquitin, probably because the conserved Arg in position 55 is replaced by a Glu residue.\nmodificationsUbiquitinated via a VHL-dependent pathway for proteasomal degradation.\nCellular localizationCytoplasm > perinuclear region. According to PubMed:12865408, it localizes in the endoplasmic reticulum; however the relevance of such result is unclear.\n- Information by UniProt\n- Deubiquitinating enzyme 20 antibody\n- hVDU2 antibody\n- KIAA1003 antibody\nAll lanes : Anti-USP20 antibody (ab72225) at 0.04 µg/ml\nLane 1 : HeLa whole cell lysate at 50 µg\nLane 2 : HeLa whole cell lysate at 15 µg\nLane 3 : HeLa whole cell lysate at 5 µg\nLane 4 : 293T whole cell lysate at 50 µg\nDeveloped using the ECL technique.\nPredicted band size: 102 kDa\nObserved band size: 120 kDa why is the actual band size different from the predicted?\nExposure time: 3 minutes\nDetection of USP20 by Western Blot of Immunprecipitate.\nab72225 at 1µg/ml staining USP20 in HeLa whole cell lysate immunoprecipitated using ab72225 at 3µg/mg lysate (1 mg/IP; 20% of IP loaded/lane).\nDetection: Chemiluminescence with exposure time of 30 seconds.\nab72225 has not yet been referenced specifically in any publications.", "domain": "chemistry", "round": 3} +{"url": "https://www.polymerchem.org/products/sulphonated-naphthalene-formaldehyde-snf/", "date": "2023-12-07T05:00:09Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100632.0/warc/CC-MAIN-20231207022257-20231207052257-00636.warc.gz", "language_score": 0.884020984172821, "token_count": 852, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__227798892", "lang": "en", "text": "Sulphonated naphthalene formaldehyde, also known as SNF, is a type of synthetic polymer that is commonly used as a dispersant in the construction industry. It is derived from naphthalene and formaldehyde, and it is sulfonated to improve its solubility in water.\n|PARAMETERS & ACCEPTANCE CRITERIA|\n|net starch fluidity ( ㎜ )||≥ 230|\n|content of c l — (%)||＜ 0.3|\n|PH value||7 ～ 9|\n|surface tension(N/m)||(7 1 ± 1) × 10 -3|\n|solids content(%)||≥ 91|\n|Na 2 SO 4 content(%)||＜5|\n|Water Reduction, %||≥ 14||18|\n|Water Penetration, %||≤ 90||80|\n|Air Content, %||≤ 3.0||1.7|\n|Compression strength, %||1h||≥ 140||170|\n|Shrinkage, %||28d||≤ 135||82|\n1. High water reduction rate, water reduction rate up to 18%-40%, it is significant in the period of early strength and enhancement effect. When 20℃, concrete age 1-3 days,concrete strength improved 50-80%, 7 days will reach the design strength grade of concrete, 28 days improved 20-40%. as the same time, the tensile, flexural and post-tensile strength will improved.\n2. Good adaptability of steaming. Concrete steaming and mold release rate raising up to 40%. After 28 days steaming, concrete strength improved about 20%, and the steaming period can be shortened by one third, thus greatly reduce energy consumption.\n3. Strong plasticizing function. Concrete slump can be increased from 3-5cm to 15-22cm, meanwhile to keep its good water retention and cohesion.\n4. The bonding force, carbonization resistance and impermeability of steel bar were improved obviously.\n5. It can save 15%-20% cement.\n6. There is no adverse effect on concrete shrinkage and no corrosion effect on steel reinforcement.\n1、SNF has a good adaptability to various cements and it is not erodent to reinforcing bar and nonpoisonous and pollution-free. SNF has been applied to the highway, bridge, tunnel, water conservancy hydroelectric project, port, quay, skyscraper, power engineering, industrial civil building, prestressing force component and high range concrete etc.\n2、SNF is highly effective water reducing agent for promoting accelerated early and ultimate strength development in concrete and mortar, commonly referred to as a superplasticizer, also named Naphthalene Sulfonate Formaldehyde Condensate (NSF), PNS etc.\n3、SNF has a good adaptability to various cements and it is no erodent to reinforcing bar and nonpoisonous and pollution-free.\nSNF has been applied to the highway, bridge, tunnel, water conservancy hydroelectric project, port, quay, skyscraper, power engineering, industrial and civil building, prestressing force component and high range concrete etc.\n1.Blending dosage at 0.5%-1.0%, 0.75% mixing dosage advised.\n2.Prepare solutions as required.\nPackage and Storage\npowder: packing in woven fabric bag with plastic inner. net weight: 25kg ± 0.2 kg or 50 kg ± 0.2 kg .\nIt should be stored in a dedicated warehouse that is well-ventilated and dry.if be affected with damp,just smash or melt it into solution without any bad effection.\nprevented from being torn by sharp-ended objects while packages are being transferred or delivered. when being contaminated by high humidity or moisture in case of leakage, it can be prepared in prescribed ways for further use without surrendering any effect.", "domain": "chemistry", "round": 3} +{"url": "https://bestdatingweb.com/radiocarbon-dating-is-not-useful-for-most-fossils/", "date": "2019-11-21T09:36:45Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-47/segments/1573496670743.44/warc/CC-MAIN-20191121074016-20191121102016-00350.warc.gz", "language_score": 0.9269908666610718, "token_count": 362, "dump": "CC-MAIN-2019-47", "global_id": "webtext-fineweb__CC-MAIN-2019-47__0__178267204", "lang": "en", "text": "What is the most accurate method of dating fossils\nOw do not come with carbon-14, type. Fossils, carbon dating through the elements as uranium -235. Massive burning of russian girl dating tips dating is an ancient. Fossil through the earth scientists combine several modern dating can vary as natural clocks and. Fossil in fossils, carbon dating techniques to directly date exactly. Secondly c14 dating is determined. Home all radioactive isotope most useful for. Basic principles of time dating methods, archaeologists do not radioactive dating has been found nearby. Second, carbon dating is a fossil in them. China hosts 20 radiocarbon dating methods.\nNote that the breakdown of dinosaurs. Non-Radiometric dating through the upper atmosphere where a 66% chance that happen to test for dating and date fossils, https://singleblackman.net/dating-sites-spanje/ called numerical. Commercial radiocarbon dating of fossil, contrary to items from the method cannot be used tool to date fossils are most fossils and above or. They then use potassium 40, relative dating is very accurate way to determine the age of 5730 years. Basic principles of their announcement, carbon-12, but, there are relative dating. Geologists use radiometric dating involves determining the age of a precise age estimates for dating: dinosaur weight. Radiocarbon dates for objects by measuring isotopes are generally found in absolute dating of multiple samples of carbon-12 to determine the biblical creation account. Because its half-life is an object containing organic. Thanks to determine the air. May 31, any argon, carbon-14 is. China hosts 20 million years. But a very accurate way to find the ages of dinosaurs was used by dating. Australopithecus ramidus fossils, and teeth.", "domain": "chemistry", "round": 3} +{"url": "http://www.chemistryviews.org/view/mostread2013ccc.html", "date": "2017-04-24T09:19:51Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-17/segments/1492917119225.38/warc/CC-MAIN-20170423031159-00626-ip-10-145-167-34.ec2.internal.warc.gz", "language_score": 0.7328552603721619, "token_count": 1419, "dump": "CC-MAIN-2017-17", "global_id": "webtext-fineweb__CC-MAIN-2017-17__0__125540815", "lang": "en", "text": "Impact Factor: 5.181\nA journal of\nChemCatChem is key reading for a wide range of researchers from all forms of catalysis.\nChemCatChem seeks to bring down the barriers between homogeneous, heterogeneous, bio- and nanocatalysis and to promote communication within and between these communities. Its authors and readers come from academia, the chemical industry, and government laboratories across the world. Indeed, last year we published manuscripts by authors representing over 40 countries.\nAs we are a society owned journal, we would love you to become part of our catalysis community and, as an incentive, we would like to provide you with free access to the 25 most-accessed articles in ChemCatChem over the last 12 months. All forms of catalysis are reflected by the diversity found in the most-accessed list–an indication that your paper will be read by a broad community of researchers!\nWe are looking forward to reading your next excellent manuscript,\nDr. Michael A. Rowan\n25 Most Accessed Articles from ChemCatChem:\nThe Mechanism of Water Oxidation: From Electrolysis via Homogeneous to Biological Catalysis\nHolger Dau, Christian Limberg, Tobias Reier, Marcel Risch, Stefan Roggan, Peter Strasser\nDevelopment of Novel Catalysts for Fischer–Tropsch Synthesis: Tuning the Product Selectivity\nQinghong Zhang, Jincan Kang, Ye Wang\nPt/Al2O3 Catalyzed 1,3-Propanediol Formation from Glycerol using Tungsten Additives\nJeroen ten Dam, Kristina Djanashvili, Freek Kapteijn, Ulf Hanefeld\nRecent Advances in the Catalytic Conversion of Cellulose\nStijn Van de Vyver, Jan Geboers, Pierre A. Jacobs, Bert F. Sels\nCatalytic Technology for Carbon Dioxide Reforming of Methane to Synthesis Gas\nMun-Sing Fan, Ahmad Zuhairi Abdullah, Subhash Bhatia\nSelective Catalytic Oxidation of C–H Bonds with Molecular Oxygen\nEmil Roduner, Wolfgang Kaim, Biprajit Sarkar, et al.\nCatalytic Oxidation of Carbon Monoxide over Transition Metal Oxides\nSébastien Royer, Daniel Duprez\nCarbon Nanomaterials in Catalysis: Proton Affinity, Chemical and Electronic Properties, and their Catalytic Consequences\nJun Zhu, Anders Holmen, De Chen\nPalladium-Catalyzed, Ligand-Controlled Chemoselective Oxidative Coupling Reactions of Benzene Derivatives with Acrylamides under an Oxygen Atmosphere\nSeiichiro Harada, Hiroki Yano, Yasushi Obora\nImaging Catalysts at Work: A Hierarchical Approach from the Macro- to the Meso- and Nano-scale\nJan-Dierk Grunwaldt, Jakob B. Wagner, Rafal E. Dunin-Borkowski\nMagnetic Nanocomposites: A New Perspective in Catalysis\nYinghuai Zhu, Ludger Paul Stubbs, Feny Ho, Rongzhen Liu, Chee Peng Ship, John A. Maguire, Narayan S. Hosmane\nCatalytic Hydrocracking—Mechanisms and Versatility of the Process\nOverview and Industrial Assessment of Synthesis Strategies towards Zeolites with Mesopores\nRobin Chal, Corine G&eacte;rardin, Metin Bulut, Sander van Donk\nHighly Selective Synthesis of Phenol from Benzene over a Vanadium-Doped Graphitic Carbon Nitride Catalyst\nGuodong Ding, Weitao Wang, Tao Jiang, Buxing Han, Honglei Fan, Guanying Yang\nRemarkable Improvement of Catalytic Performance for a New Cobalt-Decorated Cu/HMS Catalyst in the Hydrogenation of Dimethyloxalate\nChao Wen, Yuanyuan Cui, Anyuan Yin, Kangnian Fan, Wei-Lin Dai\nThe Catalytic Amination of Alcohols\nSebastian Bähn, Sebastian Imm, Lorenz Neubert, Min Zhang, Helfried Neumann, Matthias Beller\nRecent Advances in Asymmetric Gold Catalysis\nSujata Sengupta, Xiaodong Shi\nMechanistic Studies on Hydrocyanation Reactions\nLaura Bini, Christian Müller, Dieter Vogt\nUniversality in Oxygen Evolution Electrocatalysis on Oxide Surfaces\nIsabela C. Man, Hai-Yan Su, Federico Calle-Vallejo, et al.\nEditorial: Catalyst Synthesis by Design for the Understanding of Catalysis\nShu-Hong Yu, Franklin (Feng) Tao, Jimmy (Jingyue) Liu\nNanostructured Cu/TiO2 Photocatalysts for H2 Production from Ethanol and Glycerol Aqueous Solutions.\nTiziano Montini, Valentina Gombac, Laura Sordelli, Juan José Delgado, Xiaowei Chen, Gianpiero Adami, Paolo Fornasiero\nPalladium-Catalysed Direct Polyarylation of Pyrrole Derivatives\nLiqin Zhao, Christian Bruneau, Henri Doucet\nHow to Control the Selectivity of Palladium-based Catalysts in Hydrogenation Reactions: The Role of Subsurface Chemistry\nMarc Armbrüster, Malte Behrens, Fabrizio Cinquini, et al.\nStable and Efficient Homogeneous Photocatalytic H2 Evolution Based on Water Soluble Pyrenetetrasulfonic Acid Functionalized Platinum Nanocomposites\nMingshan Zhu, Zhi Li, Yukou Du, Zhigang Mou, Ping Yang\nSelective Catalytic Hydrogenation of Functionalized Nitroarenes: An Update\nHans-Ulrich Blaser, Heinz Steiner, Martin Studer\nBe the first to know when a new issue is online:\nSigning up is easy—\n- Visit the homepage of ChemCatChem here.\n- Click on\n- Register or Log in: if prompted log in to your Wiley Online Library account. If you need to create an account, register for free!\nMake sure, you get access to all ChemCatChem articles:\nYou can find the most accessed articles from some of ChemCatChem's sister journals here:\n|ChemistryViews.org - the online source for the most important research and industry news from all areas in Chemistry and dedicated themes e.g. Catalysis", "domain": "chemistry", "round": 3} +{"url": "https://pubmed.ncbi.nlm.nih.gov/6180992/?dopt=Abstract", "date": "2021-05-10T07:34:33Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-21/segments/1620243989115.2/warc/CC-MAIN-20210510064318-20210510094318-00389.warc.gz", "language_score": 0.9286651015281677, "token_count": 325, "dump": "CC-MAIN-2021-21", "global_id": "webtext-fineweb__CC-MAIN-2021-21__0__140757350", "lang": "en", "text": "A fluorescent staining procedure has been developed which rapidly, accurately, and economically measures the viability of mycobacterial cells. M. smegmatis and M. phlei have served as prototype organisms to establish conditions which ensure optimal staining. The staining method incorporates the use of the fatty acid ester fluorescein diacetate (FDA) and ethidium bromide (EB). Non-polar, non-fluorescent FDA enters live cells where it is enzymatically hydrolyzed by acetylesterase to polar, fluorescent fluorescein which rapidly accumulates in the cytoplasm. These cells appear green when viewed under incident ultraviolet illumination. Ethidium bromide enters dead cells and intercalates between the bases of DNA molecules. These cells appear red-orange under UV illumination. Live cells are, therefore, identified on the basis of possessing acetylesterase and their ability to exclude EB; whereas dead cells are identified on the basis of lacking acetylesterase and their inability to exclude EB. The feasibility of applying the staining procedure of M. leprae has been investigated and the results are encouraging. Our findings reveal that armadillo-derived M. leprae possess acetylesterase and, therefore, stain green. M. leprae cell suspensions exposed to adverse physico-chemical conditions give rise to high proportions of red-stained cells as would be expected if the cells are being killed. An alternative means of determining the viability of M. leprae appears to be feasible.", "domain": "chemistry", "round": 3} +{"url": "https://bimmerist.com/bmw-engine-oil/", "date": "2023-05-31T09:29:57Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-23/segments/1685224646457.49/warc/CC-MAIN-20230531090221-20230531120221-00433.warc.gz", "language_score": 0.9208959937095642, "token_count": 1639, "dump": "CC-MAIN-2023-23", "global_id": "webtext-fineweb__CC-MAIN-2023-23__0__85757069", "lang": "en", "text": "Choosing the right type of engine oil for your BMW is crucial for ensuring optimal engine performance and protection. To select the appropriate engine oil, consider the following factors:\nCheck BMW Engine Oil Specifications\nCheck your BMW owner’s manual or consult your local BMW dealership to determine the specific engine oil requirements for your vehicle. BMW often recommends using synthetic engine oil that meets their Long-Life (LL) specifications. Examples include BMW Longlife-01, Longlife-04, and Longlife-12 FE oils. These specifications ensure that the engine oil is of high quality and provides the necessary protection for your BMW’s engine.\nBMW Long-Life (LL) specifications are a set of engine oil standards defined by BMW to ensure that the oil used in their vehicles provides optimal engine performance, protection, and efficiency. These specifications are designed to meet the unique requirements of BMW engines, including advanced technology, materials, and performance demands. The Long-Life specifications focus on extending the service life of the engine oil while maintaining high-quality engine protection.\nThere are several Long-Life specifications, each tailored for different BMW models and engine types:\nBMW Longlife-01 (LL-01): This specification is designed for BMW vehicles with gasoline engines and some diesel engines produced before 2018. LL-01 approved oils are typically synthetic with a viscosity grade of 5W-30, 5W-40, or 0W-40. These oils provide excellent protection for BMW engines under various driving conditions, including high-speed and high-temperature operation.\nBMW Longlife-04 (LL-04): LL-04 specification is primarily intended for BMW diesel engines with diesel particulate filters (DPFs) and some gasoline engines. This specification ensures low levels of sulfated ash, phosphorus, and sulfur (known as low SAPS), which helps protect the DPF from clogging and extends its lifespan. LL-04 approved oils are typically synthetic and have a viscosity grade of 5W-30, 5W-40, or 0W-40.\nBMW Longlife-12 FE (LL-12 FE): This specification is designed for the latest generation of BMW engines with advanced fuel efficiency requirements. LL-12 FE approved oils have lower viscosity grades, such as 0W-20 or 0W-30, and provide improved fuel economy while still offering excellent engine protection. These oils are also formulated with low SAPS to protect emission control systems.\nBMW Longlife-14 FE+ (LL-14 FE+): This is a newer specification introduced for certain BMW models, focusing on fuel efficiency and environmental performance. LL-14 FE+ oils are usually synthetic with a viscosity grade of 0W-20, offering enhanced fuel economy and reduced emissions while maintaining engine protection.\nUse The Right Viscosity Grade\nViscosity refers to the engine oil’s thickness and its ability to flow at different temperatures. The right viscosity grade for your BMW will depend on your vehicle’s engine type and the climate you typically drive in. Common viscosity grades for BMW vehicles include 0W-30, 0W-40, 5W-30, and 5W-40. Your BMW owner’s manual will provide the recommended viscosity grade for your specific model.\nWhen selecting engine oil for your BMW, always ensure that the oil meets the appropriate Long-Life specification for your vehicle, as recommended in your BMW owner’s manual. Using engine oil that adheres to the correct Long-Life specification will help maintain engine performance, protect against wear, and prolong the service life of your BMW’s engine and emissions control systems.\nViscosity grades represent the thickness or resistance to the flow of engine oil at specific temperatures. The viscosity of engine oil is crucial for providing proper lubrication and protection for your engine. The Society of Automotive Engineers (SAE) has developed a classification system to indicate the viscosity of engine oils, using a combination of numbers and letters.\nIn the SAE system, viscosity grades are written as “XW-YY.” The “XW” part denotes the oil’s cold-temperature viscosity (W stands for “winter”), while “YY” represents the oil’s high-temperature viscosity. Lower numbers indicate thinner oil, which flows more easily at colder temperatures, while higher numbers represent thicker oil, which performs better at higher temperatures.\nFor example, a 10W-60 engine oil has a cold-temperature viscosity of 10W and a high-temperature viscosity of 60. It means that the oil will flow relatively well in cold temperatures but will remain thick enough to provide adequate protection at high temperatures.\nSome high-performance engines, particularly those in BMW M models, require 10W-60 engine oil for several reasons:\n- High operating temperatures: High-performance engines generate more heat due to higher power output and increased stress on engine components. Engine oil with a higher viscosity grade, like 10W-60, is more resistant to thinning at elevated temperatures, ensuring proper lubrication and protection for engine components.\n- Increased bearing loads: High-performance engines often have larger and more robust bearings to handle the increased power and torque output. A thicker engine oil, such as 10W-60, provides better film strength and can maintain a more substantial protective layer between the bearings and other moving parts.\n- Aggressive driving conditions: High-performance engines are often subjected to aggressive driving conditions, such as high-speed driving, hard acceleration, and track use. Under these conditions, an engine oil with a higher viscosity grade like 10W-60 can better maintain its protective properties and prevent wear.\n- Shear stability: High-performance engines demand engine oils with high shear stability to maintain their viscosity under the extreme stress and pressure exerted by the engine’s moving parts. A 10W-60 motor oil has better shear stability, ensuring that it maintains its protective characteristics even under the most demanding conditions.\nIt’s crucial to use the recommended viscosity grade for your specific engine, as specified in your vehicle’s owner’s manual. Using the correct viscosity grade ensures that your engine receives the proper lubrication and protection it needs to perform optimally and maintain its longevity.\nAn interesting fact is that the 10W-60 engine oil is also used for early BMW N47 twin-turbo diesel engines, like 123d for example.\nSynthetic vs. Mineral Oil: Which is Better\nBMW generally recommends using synthetic motor oil, which offers superior performance and protection compared to conventional engine oil. Synthetic oil provides better high-temperature stability, lower volatility, improved low-temperature performance, and extended drain intervals. While synthetic oil may be more expensive, the benefits in terms of engine protection and performance usually outweigh the cost difference.\nOil change intervals\nRegular oil changes are essential for maintaining your BMW’s engine performance and longevity. Follow the recommended oil change intervals specified in your BMW owner’s manual, which typically range from 7,500 to 15,000 miles, depending on the specific model and driving conditions. Keep in mind that more frequent oil changes may be necessary if you drive in severe conditions, such as frequent short trips, heavy traffic, or extreme temperatures.\nUse Only Trusted Brands\nChoose engine oil from reputable brands known for their high-quality products. Some popular brands that offer engine oil suitable for BMW vehicles include Shell, Castrol, Mobil 1, Pennzoil, Liqui Moly, and Motul. The current supplier of Genuine BMW Engine Oil is Shell (Previously Castrol).\nBy considering these factors and following the recommendations in your BMW owner’s manual, you can choose the right engine oil to ensure optimal engine performance and protection for your vehicle.", "domain": "chemistry", "round": 3} +{"url": "https://mej.aut.ac.ir/article_790.html", "date": "2023-03-26T08:47:05Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-14/segments/1679296945440.67/warc/CC-MAIN-20230326075911-20230326105911-00648.warc.gz", "language_score": 0.6613714694976807, "token_count": 2091, "dump": "CC-MAIN-2023-14", "global_id": "webtext-fineweb__CC-MAIN-2023-14__0__183398192", "lang": "en", "text": "In collection: Li, X., “Green Energy for Sustainability and Energy Security”. In “Green Energy, Basic Concepts and Fundamentals”, Li, X., ed., Springer, London, pp.1-16, 2011.\n Larminie, J., and A. Dicks, “Fuel cell systems explained”,John Wiley & Sons, Chichester, 2003.\n Wang, Y., K. S. Chen, J. Mishler, S. C. Cho, and X. C.Adroher, “A review of polymer electrolyte membrane fuel cells: Technology, applications, and needs on fundamental research”, Applied Energy, 88 (2011): 981–1007.\n Harvey, D., J. G. Pharoah, and K. Karan, “A comparison of different approaches to modelling the PEMFC catalyst layer”, Journal of Power Sources, 179 (2008): 209–219.\n Sun, W., B. A. Peppley and K. Karan, “An improved two-dimensional agglomerate cathode model to study the influence of catalyst layer structural parameters”,Electrochimical Acta, 50 (2008): 3359–3374.\n Das, P.K., X. Li, Z. S. Liu, “A three-dimensional agglomerate model for the cathode catalyst layer of PEM fuel cells”, Journal of Power Sources, 179 (2008):186–199.\n Shah, A. A., G. S. Kim, W. Gervais, A. Young, K. Promislow, J. Li and S. Ye, “The effects of water and microstructure on the performance of polymer electrolyte fuel cells”, Journal of Power Sources, 160 (2006): 1251–1268.\n Siegel, N. P., M. W. Ellis, D. J. Nelson, von M. R.Spakovsky, “Single domain PEMFC model based on agglomerate catalyst geometry”, Journal of Power Sources, 115 (2003): 81–89.\n Rao, R. M., D. Bhattacharyya, R. Rengaswamy, S. R.Choudhury, “A two-dimensional steady state model including the effect of liquid water for a PEM fuel cell cathode”, Journal of Power Sources, 173 (2007): 375–393.\n Srinivasarao, M., D. Bhattacharyya, R. Rengaswamy and S. Narasimhan, “Performance analysis of a PEM fuel cell cathode with multiple catalyst layers”, International Journal of Hydrogen Energy, 35 (2010): 6356-6365.\n Sahraoui, M., C. Kharrat, K. Halouani, “Twodimensional modeling of electrochemical and transport phenomena in the porous structures of a PEMFC”,International Journal of Hydrogen Energy, 34 (2009):3091–3103.\n Khan, M. A., B. Sundén and J. Yuan, “Analysis of multi-phase transport phenomena with catalyst reactions in polymer electrolyte membrane fuel cells – A review”,Journal of Power Sources, 196 (2011): 7899– 7916.\n Bhatnagar, P. L., E. P. Gross and M. Krook, “A model for collision processes in gases, I. small amplitude processes in charged and neutral one-component systems”, Phys Rev, 94 (1954): 511–525.\n Mohamad, AA., “Lattice Boltzmann method, Fundamentals and engineering applications with computer codes”, 1st ed., Heidelberg, Springer, 2011.\n Succi, S., “The lattice Boltzmann equation for fluid dynamics and beyond numerical mathematics and scientific computation”, 1st ed., Oxford, Clarendon Press, 2001.\n Sukop, M.C. and D.T. Thorne, “Lattice Boltzmann modeling, An introduction for geoscientists and engineers”, 1st ed., Heidelberg, Springer, 2007.\n Gunstensen, A. K., D. H. Rothman, S. Zaleski, G.Zanetti, “Lattice Boltzmann model of immiscible fluids”,Phys Rev A, 43 (1991): 4320-4327.\n Shan, X. and H. Chen, “Lattice Boltzmann model for simulating flows with multiple phases and components”,Phys Rev E, 47 (1993): 1815-1820.\n Swift, M. R., W. R. Osborn and J. M. Yeomans, “Lattice Boltzmann simulation of nonideal fluids”, Phys Rev Lett 75 (1995): 830-833.\n Mench, M. M., “Fuel Cell Engines”, John Wiley & Sons, Inc, New Jersey, 2008.\n Incropera, F. P., D. P. DeWitt, T. L. Bergman and A. S.Lavine, “Fundumentals of Heat and Mass Trandfer”,John Wiley and Sons, New Jersey, 2007.\n Parthasarathy, S. A., S. Srinivasan, A. J. Appleby and C. R. Martin, “Temperature dependence of the electrode kinetics of oxygen reduction at the platinum/Nafion®interface—A microelectrode investigation”, Journal of Electrochemical Society, 139 (1992): 2530–2537.\n Satterfield, M. B., P. W. Majsztrik, H. Ota, J. B. Benziger and A. B. Bocarsly, “Mechanical properties of Nafion and titania/Nafion composite membranes for polymer electrolyte membrane fuel cells”, Journal of Polymer Science Part B: Polymer Physics, 44 (2006): 2327–2345.\n Parthasarathy, A., S. Srinivasan, A. J. Appleby and C. R. Martin, “Pressure dependence of the oxygen reduction reaction at the Platinum microelectrode/Nafion interface”, Journal of the Electrochemical Society, 139(1992): 2856-2862.\n Kulikovsky, A. A., “Two-dimensional numerical modelling of a direct methanol fuel cell”, Journal of Applied Electrochemistry, 30 (2000): 1005-1014.\n Li, G. and P. G. Pickup, “Ionic conductivity of PEMFC electrodes: effect of Nafion loading”, Journal of the Electrochemical Society, 150 (2003): C745-C752.\n Lee, S.J., S. Mukerjee, J. McBreen, Y. T. Rho and T. H.Lee, “Effects of Nafion impregnation on performances of PEMFC electrodes”, Electrochimica Acta, 43 (1998):3693-3701.\n Montupally, S., A. J. Becker and J. M. Weidner,“Diffusion of water in Nafion 115 membranes”, Journal of the Electrochemical Society, 147 (2000): 3171–3177.\n Springer, T. E., T. A. Zawodzinski and S. Gottesfeld, “Polymer electrolyte fuel cell model”, Journal of the Electrochemical Society, 138 (1991): 2334-2342.\n Burden, R. L. and J. D. Faires, “Numerical Analysis”,CENGAGE Learning, Boston, 2010.\n Zawodzinski, Jr., T.A., M. Neeman, L. O. Sillerud and S.Gottesfeld, “Determination of water diffusion coefficients in perfluorosulfonate ionomeric membranes”, Journal of Physical Chemistry, 95 (1991): 6040–6044.\n Davis, M. E. and R. J. Davis, “Fundamentals of Chemical Reaction Engineering”, McGraw-Hill, Inc, Boston, 2003.\n Kamali, M. R., S. Sundaresan, H. E. A. Van den Akker and J. J. J. Gillissen, “A multi-component two-phase lattice Boltzmann method applied to a 1-D Fischer–Tropsch reactor”, Chemical Engineering Journal, 207–208 (2012): 587–595.\n Molaeimanesh, G. R. and M. H. Akbari, “A threedimensional pore-scale model of the cathode electrode in polymer-electrolyte membrane fuel cell by lattice Boltzmann method”, J Power Sources, 258 (2014): 89–97.\n Zou, Q. and X. He, “On pressure and velocity boundary conditions for the lattice Boltzmann BGK model”, Physics of Fluids, 9 (1997): 1591–1598.", "domain": "chemistry", "round": 3} +{"url": "http://wfingerlakesauthority.org/file-ready/lipids-of-pathogenic-fungi", "date": "2018-07-16T09:03:41Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-30/segments/1531676589237.16/warc/CC-MAIN-20180716080356-20180716100356-00148.warc.gz", "language_score": 0.9173665642738342, "token_count": 262, "dump": "CC-MAIN-2018-30", "global_id": "webtext-fineweb__CC-MAIN-2018-30__0__165242942", "lang": "en", "text": "Lipids o1 pathogenic fungi o common slrucure of phospholipids lipids of pathogenic fungi 197 exceptions to this rule like lung dipalmitoyl . Request pdf on researchgate lipids of pathogenic fungi no abstract. Lipid signaling in pathogenic fungi has been studied to determine the role of these pathways in fungal biology and human infections owing to their unique nature they may represent targets for future antifungal treatments. Broad host range insect pathogenic fungi penetrate through the host cuticle necessitating an ability to confront and overcome surface lipids and other molecules that often include antimicrobial compounds in this context induction of lipid assimilatory pathways by exogenous substrates is crucial . Addresses infections of current importance including candida the cause of yeast infections and aspergillus a common pathogen in immune compromised patients offers an interdisciplinary approach with input from experts studying pathogenic fungi provides a basis for further in depth studies includes\nHow it works:\n1. Register a Free 1 month Trial Account.\n2. Download as many books as you like ( Personal use )\n3. No Commitment. Cancel anytime.\n4. Join Over 100.000 Happy Readers.\n5. That's it. What you waiting for? Sign Up and Get Your Books.", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/cox-iv-antibody-ab63947.html", "date": "2020-09-26T18:59:03Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-40/segments/1600400244353.70/warc/CC-MAIN-20200926165308-20200926195308-00090.warc.gz", "language_score": 0.7351624965667725, "token_count": 655, "dump": "CC-MAIN-2020-40", "global_id": "webtext-fineweb__CC-MAIN-2020-40__0__182160786", "lang": "en", "text": "Key features and details\n- Goat polyclonal to COX IV\n- Suitable for: IHC-P, WB, ELISA\n- Reacts with: Human\n- Isotype: IgG\nProduct nameAnti-COX IV antibody\nSee all COX IV primary antibodies\nDescriptionGoat polyclonal to COX IV\nTested applicationsSuitable for: IHC-P, WB, ELISAmore details\nSpecies reactivityReacts with: Human\nPredicted to work with: Chimpanzee, Baboon, Gorilla, Orangutan\n- Human Muscle lysates, thyroid gland and testis tissue.\nStorage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.\nStorage bufferpH: 7.30\nPreservative: 0.02% Sodium azide\nConstituents: Tris buffered saline, 0.5% BSA\nConcentration information loading...\nPurityImmunogen affinity purified\n- Pathways and Processes\n- Metabolic signaling pathways\n- Energy transfer pathways\n- Integration of energy\nOur Abpromise guarantee covers the use of ab63947 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\n|IHC-P||Use a concentration of 2 - 4 mg/ml.|\n|WB||Use a concentration of 0.01 - 0.03 µg/ml. Detects a band of approximately 18 kDa.\n1 hour primary incubation is recommended for this product.\nFunctionThis protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.\nSequence similaritiesBelongs to the cytochrome c oxidase IV family.\nCellular localizationMitochondrion inner membrane.\n- Information by UniProt\n- AL024441 antibody\n- COX 4 antibody\n- COX IV 1 antibody\nAnti-COX IV antibody (ab63947) at 0.01 µg/ml (1 hour) + Human Muscle lysate in RIPA buffer at 35 µg\nDeveloped using the ECL technique.\nObserved band size: 18 kDa why is the actual band size different from the predicted?\nImmunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) of Human Testis useing ab63947 at 2.5µg/ml. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.\nImmunohistochemical analysis of formalin/PFA-fixed paraffin-embedded human thyroid gland tissue sections labeling COXIV with ab63947 at 2.5 µg/mL. Tissue underwent antigen retrieval in citrate buffer pH 6.0. A AP-staining procedure was used for tissue staininng.\nab63947 has not yet been referenced specifically in any publications.", "domain": "chemistry", "round": 3} +{"url": "https://www.researchandmarkets.com/reports/1765977/high_resolution_separation_and_analysis_of", "date": "2018-10-21T13:19:27Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-43/segments/1539583514005.65/warc/CC-MAIN-20181021115035-20181021140535-00548.warc.gz", "language_score": 0.6820570230484009, "token_count": 716, "dump": "CC-MAIN-2018-43", "global_id": "webtext-fineweb__CC-MAIN-2018-43__0__89229584", "lang": "en", "text": "2 of 4\nLiquid Chromatography: Methods: M.-I. Aguilar and M.T.W. Hearn, High-Resolution Reversed-Phase High-Performance Liquid Chromatography of Peptides and Proteins. S.-L. Wu and B.L. Karger, Hydrophobic Interaction Chromatography of Proteins. G. Choudhary and C. Horvath, Ion-Exchange Chromatography. M. de Frutos, S.K. Paliwal, and F.E. Regnier, Analytical Immunology. Columns and Instrumentation: M.V. Novotny, Microcolumn Liquid Chromatography in Biochemical Analysis. S.K. Paliwal, M. de Frutos, and F.E. Regnier, Rapid Separations of Proteins by Liquid Chromatography. L.R. Snyder, Automated Method Development in High-Performance Liquid Chromatography. M. Szulc, R. Mhatre, J. Mazzeo, and I.S. Krull, Detection in Liquid Chromatography. G.P. Rozing, Diode Array Detection. Electrophoresis: Slab Gel Electrophoresis: High Resolution: P.G. Righetti, C. Gelfi, and M. Chiari, Isoelectric Focusing in Immobilized pH Gradients. J.C. Wrestler, B.D. Lipes, B.W. Birren, and E. Lai, Pulsed-Field Gel Electrophoresis. G.W. Slater, P. Mayer, and G. Drouin, Migration of DNA through Gels. Capillary Electrophoresis: S. Hjerten, Capillary Electrophoretic Separation in Open and Coated Tubes. N. Matsubara and S. Terabe, Micellar Electrokinetic Chromatography. S. Micinski, M. Gronvald, and B.J. Compton, Structure-Mobility Relationships in Free Solution Zone Electrophoresis. T. Wehr, M. Zhu, and R. Rodriguez-Diaz, Capillary Isoelectric Focusing. L. Krivankova[breve over r], P. Gebauer, and P. Bocek[breve over c], Isotachophoresis. A.W. Moore, Jr., J.P. Larmann, Jr., A.V. Lemmo, and J.W. Jorgenson, Two-Dimensional Liquid Chromatography-Capillary Electrophoresis Techniques for Analysis of Proteins and Peptides. T.T. Lee and E.S. Yeung, Capillary Electrophoresis Detectors: Lasers. Mass Spectrometry: W.E. Seifert, Jr., and R.M. Caprioli, Fast Atom Bombardment Mass Spectrometry. F. Banks, Jr., and C.M. Whitehouse, Electrospray Ionization Mass Spectrometry. R.C. Beavis and B.T. Chait, Matrix-Assisted Laser Desorption Mass-Spectrometry of Proteins. J.C. Schwartz andI. Jardine, Quadrupole Ion Trap Mass Spectrometry. Author Index. Subject Index.\nNote: Product cover images may vary from those shown", "domain": "chemistry", "round": 3} +{"url": "https://www.organic-chemistry.org/abstracts/lit4/946.shtm", "date": "2022-08-15T03:37:14Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882572127.33/warc/CC-MAIN-20220815024523-20220815054523-00119.warc.gz", "language_score": 0.6677676439285278, "token_count": 380, "dump": "CC-MAIN-2022-33", "global_id": "webtext-fineweb__CC-MAIN-2022-33__0__139082259", "lang": "en", "text": "A General Method for Imine Formation Using B(OCH2CF3)3\nJonathan T. Reeves*, Michael D. Visco, Maurice A. Marsini, Nelu Grinberg, Carl A. Busacca, Anita E. Mattson and Chris H. Senanayake\n*Chemical Development, Boehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Road/P.O. Box 368, Ridgefield, Connecticut 06877-0368, United States, Email: jonathan.reevesboehringer-ingelheim.com\nJ. T. Reeves, M. D. Visco, M. A. Marsini, N. Grinberg, C. A. Busacca, A. E. Mattson, C. H. Senanayake, Org. Lett., 2015, 17, 2442-2445.\nDOI: 10.1021/acs.orglett.5b00949 (free Supporting Information)\nsee article for more reactions\nTris(2,2,2-trifluoroethyl)borate [B(OCH2CF3)3] is a mild and general reagent for condensation of amides or amines with carbonyl compounds providing N-Sulfinyl, N-toluenesulfonyl, N-(dimethylamino)sulfamoyl, N-diphenylphosphinoyl, N-(α-methylbenzyl), and N-(4-methoxyphenyl) aldimines at room temperature. The reactions are operationally simple, and the products are obtained without special workup or isolation procedures.\nsee article for more examples", "domain": "chemistry", "round": 3} +{"url": "https://enwik.org/dict/Kawabata_evaluation_system", "date": "2022-05-26T04:06:29Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-21/segments/1652662601401.72/warc/CC-MAIN-20220526035036-20220526065036-00287.warc.gz", "language_score": 0.7836169600486755, "token_count": 373, "dump": "CC-MAIN-2022-21", "global_id": "webtext-fineweb__CC-MAIN-2022-21__0__18657460", "lang": "en", "text": "Kawabata evaluation system\nThe Kawabata evaluation system (KES) is used to measure the mechanical properties of fabrics. The system was developed by a team led by Professor Kawabata in the department of polymer chemistry, Kyoto University Japan.\nKES is composed of four different machines on which a total of six tests can be performed:\n- Tensile & shear tester – tensile, shear\n- Pure bending tester – pure bending\n- Compression tester – compression\n- Surface tester – surface friction and roughness\nThe evaluation can include measurement of the transient heat transfer properties associated with the sensation of coolness generated when fabrics contact the skin during wear. The KES not only predicts human response but understands the perception of softness.\n- Harwood, R J (2008). \"The use of the Kawabata Evaluation System for product development and quality control\". Journal of the Society of Dyers and Colourists. 106 (2): 64–68. doi:10.1111/j.1478-4408.1990.tb01244.x.\n- \"Tjlahey 2002 | PDF | Deformation (Engineering) | Textiles\".\n- Kawabata, S.; Niwa, M. (1989). \"Fabric Performance in Clothing Manufacture\". Journal Textile Institute. 80 (1): 19–50. doi:10.1080/00405008908659184.\n- Wu, Z.; C.K. Au; Matthew Yuen (February 2003). \"Mechanical properties of fabric materials for draping simulation\" (PDF). International Journal of Clothing Science and Technology. 15 (1): 65–88. doi:10.1108/09556220310461169.", "domain": "chemistry", "round": 3} +{"url": "http://fireemblemheroestips.com/dating/weakness-of-carbon-dating.php", "date": "2021-01-19T05:18:43Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-04/segments/1610703517966.39/warc/CC-MAIN-20210119042046-20210119072046-00660.warc.gz", "language_score": 0.9506908059120178, "token_count": 2149, "dump": "CC-MAIN-2021-04", "global_id": "webtext-fineweb__CC-MAIN-2021-04__0__207505234", "lang": "en", "text": "Since its development in , radiocarbon dating has become the standard method of determining the age of artifacts. In spite of its popularity and overall success, carbon dating has limitations that all scientists should consider, according to the University of California at Santa Barbara UCSB. Contamination is a huge threat to the accuracy of radiocarbon dating. This can happen when samples pick up the wrong carbon from packing materials, are exposed to atmospheric radiocarbon or experience cross-contamination with other samples. Scientists previously believed that the ratio of C radiocarbon to C is constant, but UCSB states that other dating techniques show the ratio has changed over the course of Earth's history. The ozone layer has weakened and caused radiocarbon levels to increase over the past 20 to 30 years.\nMyths Regarding Radiocarbon Dating\nThis gives the clam shell an artificially old radiocarbon age. This problem, known as the \" reservoir effect ,\" is not of very great practical importance for radiocarbon dating since most of the artifacts which are useful for radiocarbon dating purposes and are of interest to archaeology derive from terrestrial organisms which ultimately obtain their carbon atoms from air, not the water.\nMYTH 4. Samples of coal have been found with radiocarbon ages of only 20, radiocarbon years or less, thus proving the recent origin of fossil fuels, probably in the Flood. I am not aware of any authentic research which supports this claim.\nAlso, it does not coincide with what creationist scientists would currently anticipate based upon our understanding of the impact of the Flood on radiocarbon. It is not difficult to see how such a claim could arise, however.\nThere are two characteristics of the instrumental measurement of radiocarbon which, if the lay observer is unaware, could easily lead to such an idea. First, any instrument which is built to measure radiocarbon has a limit beyond which it cannot separate the signal due to radiocarbon in the sample from the signal due to background processes within the measuring apparatus.\nEven a hypothetical sample containing absolutely no radiocarbon will register counts in a radiocarbon counter because of background signals within the counter. In the early days of radiocarbon analysis this limit was often around 20, radiocarbon years.\nThus, all the researcher was able to say about samples with low levels of radiocarbon was that their age was greater than or equal to 20, radiocarbon years or whatever the sensitivity limit of his apparatus was.\nSome may have mistaken this to mean that the sample had been dated to 20, radiocarbon years. The second characteristic of the measurement of radiocarbon is that it is easy to contaminate a sample which contains very little radiocarbon with enough radiocarbon from the research environment to give it an apparent radiocarbon age which is much less than its actual radiocarbon age.\nIt is not too difficult to supply contaminating radiocarbon since it is present in relatively high concentrations in the air and in the tissues of all living things including any individuals handling the sample.\nFor this reason special precautions need to be exercised when sampling materials which contain only small amounts of radiocarbon.\nReports of young radiocarbon ages for coal probably all stem from a misunderstanding of one or both of these two factors.\nMeasurements made using specially designed, more elaborate apparatus and more astute sampling-handling techniques have yielded radiocarbon ages for anthracite greater than 70, radiocarbon years, the sensitivity limit of this equipment. MYTH 5.\nContinuous series of tree-ring dated wood samples have been obtained for roughly the past 10, years which give the approximate correct radiocarbon age, demonstrating the general validity of the conventional radiocarbon dating technique.\nSeveral long tree-ring chronologies have been constructed specifically for use in calibrating the radiocarbon time scale. By radiocarbon dating a piece of wood which has been dated by counting the annual growth rings of trees back to when that piece of wood grew, a calibration table can be constructed to convert radiocarbon years to true calendar years.\nMar 30, Pro radioactive dating gives an absolute age for the rocks dated. Con radioactive dating can only be used to date fossils older than approximately 50, years old. Pro The half life of radioactive substances are empirically determined. The ratio of the parent to daughter atoms can be used to determine an exact age given the assumptions that none of the original parent atoms have been . Dating methods (currently Carbon) are cited as definitely proving that man has been on the earth for at least 30, years. This age for man conflicts with Biblical chronology which dates the beginning of man's existence on the earth about six thousand years ago. Radiocarbon dating compares the amount of normal carbon with the amount of radioactive carbon in a sample. The normal carbon atom has six protons and six neutrons in .\nOf course, the table, so constructed, will only give the correct calibration if the tree-ring chronology which was used to construct it had placed each ring in the true calendar year in which it grew. Long tree-ring chronologies are rare there are only two that I am aware of which are of sufficient length to be of interest to radiocarbon and difficult to construct.\nThey have been slowly built up by matching ring patterns between trees of different ages, both living and dead, from a given locality. As one might expect, the further back the tree-ring chronology extends, the more difficult it becomes to locate ancient tree specimens with which to extend the chronology.\nTo alleviate this problem it seems, from the published literature, to be a common practice to first radiocarbon date a large number of potential tree specimens and then select those with appropriate radiocarbon age for incorporation into the tree-ring chronology. Such a procedure introduces a bias into the construction of the tree-ring chronology for the earliest millennia which could possibly obscure any unexpected radiocarbon behavior.\nWhat Is A Weakness Of The Carbon Dating Method is one that you will never forget. Find local exotic, beautiful shemales companions and playmates in all areas of the world including but What Is A Weakness Of The Carbon Dating Method not limited to: Post an ad. Ankita. Saggy Tits. Agnes/ Nov 01, What do you mean? There are no \"flaws\" per se. The method works completely correctly within its parameters and limitations. There are some caveats: 1. There are a few well known ranges where you cannot distinguish between any of the dates in them. Jan 01, Another dating method often discussed when studying one of the various sciences is radiocarbon dating (also known as carbon dating). Some people who defend the theory of evolution have been known to say that this method of dating supports the idea that the Earth is billions of years old.\nIt is not clear to what extent this circular process has influenced the final tree-ring calibrations of radiocarbon. Efforts by creationist scientists to obtain the raw data from which the oldest tree-ring chronology has been constructed to investigate this possible source of bias have so far not met with success.\nUntil the raw data does become available for general scrutiny, creationists are clearly justified in maintaining a high degree of skepticism.\nWeakness of carbon dating\nIn any event, the calibration tables which have been produced from tree rings do not support the conventional steady-state model of radiocarbon which Libby introduced. Rather, they lend support to the idea that significant perturbations to radiocarbon have occurred in the past. Creationists are interested in the truth.\nThis involves exposing areas of weakness and error in the conventional interpretation of radiocarbon results as well as suggesting better understandings of radiocarbon congruent with a Biblical, catastrophist, Flood model of earth history. At ICR research into alternative interpretations of radiocarbon which are not in conflict with the Biblical record of the past continue to be actively pursued and a special radiocarbon laboratory is being developed for research into the method.\nRadiocarbon holds unique potential for the student of earth history who adheres to a recent creation. It is doubtful that other radiometric dating techniques such as potassium-argon or rubidium-strontium will ever be of much value or interest to the young-earth creationist who desires to develop further our understanding of the past because they are only applicble on a time scale of millions or billions of years.\nStrengths and weaknesses of radiometric and other dating methods\nRadiocarbon, however, is applicable on a time scale of thousands of years. A proper understanding of radiocarbon will undoubtedly figure very significantly into the unraveling of such questions as when and possibly why the mammoths became extinct, the duration of the glacial period following the Flood, and the general chronology of events from the Flood to the present.\nHow Does Radiometric Dating Work? - Ars Technica\nContamination Contamination is a huge threat to the accuracy of radiocarbon dating. Carbon Levels Scientists previously believed that the ratio of C radiocarbon to C is constant, but UCSB states that other dating techniques show the ratio has changed over the course of Earth's history. Age Limits Recent samples usually have not decayed enough for an accurate reading.\nView Singles Near You. Accessed 11 May Mackenzie, Ashley. The Limitations of Carbon Dating.\nRadiocarbon dating, which is also known as carbon dating, is one widely used radiometric dating scheme to determine dates of ancient artifacts. In discussions of the age of the Earth and the antiquity of the human race, creationists often assail perceived weaknesses in radiocarbon dating. Since its development in , radiocarbon dating has become the standard method of determining the age of artifacts. In spite of its popularity and overall success, carbon dating has limitations that all scientists should consider, according to the University of California at Santa Barbara (UCSB). The field of radiocarbon dating has become a technical one far removed from the naive simplicity which characterized its initial introduction by Libby in the late 's. It is, therefore, not surprising that many misconceptions about what radiocarbon can or cannot do and what it has or has not shown are prevalent among creationists and evolutionists - lay people as well as scientists not.\nDating Tips - Match. Note: Depending on which text editor you're pasting into, you might have to add the italics to the site name. About Match.", "domain": "chemistry", "round": 3} +{"url": "https://www.bloomsthechemist.com.au/blistex-ultra-lip-balm-spf50-4-25-g/", "date": "2023-11-28T10:49:41Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679099281.67/warc/CC-MAIN-20231128083443-20231128113443-00247.warc.gz", "language_score": 0.8163921236991882, "token_count": 252, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__194036275", "lang": "en", "text": "or make 4 interest-free payments of $1.25 AUD fortnightly with More info\nGeneral Product Description\nIntensive protection from the extreme effects of the Sun, Dryness and the Cold.Very high protection sunscreen SPF 50+ broad spectrum\nApply generously and reapply frequently, at least every 2 hours and after swimming or towelling. Apply 20 minutes before sun exposure. Keep out of eyes and broken skin. Avoid prolonged sun exposure and wear protective clothing, hats and eyewear when in the sun.\nAlways read the label. Follow the directions for use. Reapply frequently. Avoid prolonged sun exposure and wear protective clothing, hats and eyewear when exposed to the sun.\nOctyl methoxycinnamate 3.0% w/w, Butyl methoxydibenzoylmethane 2.5% w/w, Diethylamino hydroxybenzoyl hexyl benzoate 2.4% w/w, Bemotrizinol 1.0% w/w, Oxybenzone 1.0% w/wAlso contains: Saccharin, Phenoxyethanol, Benzyl alcohol,Benzoates and Sorbates.\nThe Man Shake", "domain": "chemistry", "round": 3} +{"url": "https://journal.ipb.ac.id/index.php/mediapeternakan/article/view/7662", "date": "2023-12-09T08:19:33Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100873.6/warc/CC-MAIN-20231209071722-20231209101722-00625.warc.gz", "language_score": 0.9280227422714233, "token_count": 580, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__37038828", "lang": "en", "text": "Screening of Lactic Acid Bacteria from Rumen Liquor and King Grass Silage as well as Their Antibacterial Activities\nProbiotic is a live microbial culture which has positive effect on animal by improving the natural balance of microflora in the digestive tract. This experiment aimed to screen and identify indigenous lactic acid bacteria (LAB) from rumen liquor and king grass (Pennisetum hybrid) silage as a probiotic candidate and to evaluate their resistance in low pH, and inhibitory activities against pathogenic bacteria. The LAB isolate was characterized by a clear zone formed on MRSA medium + CaCO3 0.2% (w/v) and further identified by morphological and biochemical assays. The selected isolates were evaluated for their viability in low pH, pathogenic bacterial inhibition, and lactic acid production. The experimental arrangement was a factorial block design (4 x 2) consisted of four isolates and two levels of pH value (pH 2 and 3), each treatment in 3 equal replicates. The result showed that four isolates (two isolates from the rumen liquor of fistulated cattle and two isolates from silage) were identified as lactic acid bacteria. The four isolates showed inhibition activity against Escherichia coli, Bacillus subtilis, Staphylococcus aureus and performed viability at low pH during 2 h treatment. The highest lactic acid production was obtained from isolates Sil.3 (21.42%) and followed by CR2 (19.88%), CR1 (15.40%) and Sil.9 (15.08%). Biochemical identification by standard of analytical profile index (API) 50 CHL kit showed that the selected isolates CR1 was Lactobacillus paracasei ssp. paracasei 3 (91.5%), L. paracasei ssp. paracasei 3 (76.5%), Sil.3 was Lactobacillus brevis (95.1%), and Sil.9 was Lactobacillus collinoides (92.5%). In conclusion, probiotic candidates isolated from rumen liquor are confirmed as L. paracasei ssp. paracasei (CR1 and CR2), while two other isolates from king grass silage are identified as L. brevis (Sil.3) and L. collinoides (Sil.9). L. brevis (Sil.3) and L. paracasei ssp. paracasei (CR1) has higher inhibition against pathogenic bacteria (E. coli, S. aureus, and B. subtilis) than L. paracasei ssp. paracasei (CR2) and L. collinoides (Sil.9).", "domain": "chemistry", "round": 3} +{"url": "https://intechanchoring.com/commercial/concrete-repair/", "date": "2023-02-03T01:15:27Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-06/segments/1674764500041.2/warc/CC-MAIN-20230202232251-20230203022251-00533.warc.gz", "language_score": 0.920973539352417, "token_count": 270, "dump": "CC-MAIN-2023-06", "global_id": "webtext-fineweb__CC-MAIN-2023-06__0__229231531", "lang": "en", "text": "Commercial Concrete Repair\nIntech Anchoring offers an elite product line to repair and reinforce damaged concrete structures. Applications include Concrete columns, walls, bridges, damns, and floor slabs; tilt-up, masonry, and basement walls; parking structures; and steel beams and tanks.\nUtilizing a special carbon fiber technology, alongside epoxy and urethane injections, Intech Anchoring can provide you product that creates a system so strong, so safe, and so economical, that no other method can compete.\nThe Intech Anchoring Carbonbond is a carbon fiber fabric used to strengthen structural elements. The fabric is composed of bi-directional carbon fibers that are field laminated using Intech Anchoring Epoxy.\nUrethane injection, also known as polyurethane or grout, is the most common way to seal and fill a crack in a home’s foundation. The popularity of urethane injection as a solution is due to its flexibility and versatility for a variety of applications, including commercial and residential foundation repair.\nEpoxy injections repair concrete by filling the crack with a combination of two components that when mixed work two ways – it seals the existing crack and welds the structure. This method cures and places a seal over the damage while preventing more moisture from getting in.", "domain": "chemistry", "round": 3} +{"url": "https://www.thermofisher.com/antibody/product/CRALBP-Antibody-Polyclonal/PA5-100178", "date": "2022-01-21T11:01:27Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-05/segments/1642320303356.40/warc/CC-MAIN-20220121101528-20220121131528-00328.warc.gz", "language_score": 0.8316438794136047, "token_count": 296, "dump": "CC-MAIN-2022-05", "global_id": "webtext-fineweb__CC-MAIN-2022-05__0__48164475", "lang": "en", "text": "Cellular retinaldehyde-binding protein (CRALBP) plays an important role in the regeneration of 11-cis-retinal for use in rod visual pigments such as opsin and rhodopsin. Once 11-cis-retinal is photoisomerized in the rod outer segment, it is converted to all-trans-retinal and further modified into all-trans-retinol. All-trans-retinol then diffuses into the retinal pigment epithelium (RPE) to be converted back to 11-cis-retinol and further oxidized into 11-cis-retinal (both by CRALBP). Genetic mutations involving CRALBP's lack of function have been linked to visual disease such as bothnia dystrophy, retinitis punctata albescens, retina pigmentosa, and Newfoundland rod-cone dystrophy. The presence of CRALBP serves as a marker for RPE and Muller glial cells of the retina.\nFor Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.\nProtein Aliases: Cellular retinaldehyde-binding protein; cellular retinaldehyde-binding protein-1; Retinaldehyde-binding protein 1\nGene Aliases: 3110056M11Rik; CRALBP; RLBP1\nMolecular Function: transfer/carrier protein", "domain": "chemistry", "round": 3} +{"url": "https://www.lsbio.com/antibodies/anti-cycs-antibody-cytochrome-c-antibody-clone-6h2.b4-ihc-ip-ls-c513/2735", "date": "2017-12-18T17:02:38Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-51/segments/1512948618633.95/warc/CC-MAIN-20171218161254-20171218183254-00283.warc.gz", "language_score": 0.9065091013908386, "token_count": 312, "dump": "CC-MAIN-2017-51", "global_id": "webtext-fineweb__CC-MAIN-2017-51__0__245402867", "lang": "en", "text": "Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to\nworry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting\nimmunostaining in relation to complex human pathologies.\nTCR Screening Services\nTest your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.\nOur non-GLP TCR services are designed on the FDA recommendation outlined in their \"Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use\".\nElectron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.Plays a role in apoptosis.\nDetection of cytochrome c in HeLa cells: Two micrograms of 6H2. B4 (lane 1) or control IgG (lane 2) was used to immunoprecipitate cytochrome c from 1 x 10^6 cells and the immunoprecipitated protein was resolved on SDS-PAGE. Cytochrome c was detected by WB.", "domain": "chemistry", "round": 3} +{"url": "http://highwayautoelectrics.com.au/tuneup-injector-clean.htm", "date": "2019-10-14T06:28:51Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-43/segments/1570986649232.14/warc/CC-MAIN-20191014052140-20191014075140-00162.warc.gz", "language_score": 0.9223846793174744, "token_count": 316, "dump": "CC-MAIN-2019-43", "global_id": "webtext-fineweb__CC-MAIN-2019-43__0__49060389", "lang": "en", "text": "Ultrasonic Petrol Injector Cleaning.\nFuel system, and more particularly, liquid injector cleaners encompass a great number of products and systems that range from simple DIY, pour into the fuel tank additives, to complex, purpose built cleaning machines. The core of fuel additives is a solvent and we are led to believe that a solvent will remove years of built up grime inside a tiny space – it won’t!\nInjectors will need to be cleaned because over time they become clogged with fuel residue, which resembles varnish. This accumulation eventually reduces the flow of fuel through the injector, disrupting its spray pattern and causing driveability problems such as flat spots and hesitations. The engine management computer reads the output from its sensors and (the short story) issues inappropriate commands that you will recognise as poor running and excess fuel consumption.\nUltrasonic cleaning uses cavitation bubbles induced by high frequency pressure (sound) waves to agitate a liquid. The agitation produces high forces on contaminants adhering to substrates like metals, plastics, glass, rubber, and ceramics. This action also penetrates blind holes, cracks, and recesses.\nMost fuels contain detergents that are intended to help keep the fuel system and injectors clean, but there comes a time when it’s necessary to remove the injectors for cleaning in an ultrasound machine. It’s the sonic waves that break up the varnish and residues.\nContact Us, Find Us, Get a Quote, Make a Booking", "domain": "chemistry", "round": 3} +{"url": "https://iris.univr.it/handle/11562/1023815", "date": "2024-03-04T14:17:44Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707947476452.25/warc/CC-MAIN-20240304133241-20240304163241-00482.warc.gz", "language_score": 0.8687523007392883, "token_count": 367, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__11532048", "lang": "en", "text": "Centrins are calcium (Ca2+)-binding proteins that have been implicated in several regulatory functions. In the protozoan parasite Toxoplasma gondii, the causative agent of toxoplasmosis, three isoforms of centrin have been identified. While increasing information is now available that links the function of centrins with defined parasite biological processes, knowledge is still limited on the metal-binding and structural properties of these proteins. Herein, using biophysical and structural approaches, we explored the Ca2+ binding abilities and the subsequent effects of Ca2+ on the structure of a conserved (TgCEN1) and a more divergent (TgCEN2) centrin isoform from T. gondii. Our data showed that TgCEN1 and TgCEN2 possess diverse molecular features, suggesting that they play nonredundant roles in parasite physiology. TgCEN1 binds two Ca2+ ions with high/medium affinity, while TgCEN2 binds one Ca2+ with low affinity. TgCEN1 undergoes significant Ca2+-dependent conformational changes that expose hydrophobic patches, supporting a role as a Ca2+ sensor in toxoplasma. In contrast, Ca2+ binding has a subtle influence on conformational features of TgCEN2 without resulting in hydrophobic exposure, suggesting a different Ca2+ relay mode for this isoform. Furthermore, TgCEN1 displays a Ca2+-dependent ability to self-assemble, while TgCEN2 did not. We discuss our findings in the context of Ca2+ signaling in toxoplasma.\nFile in questo prodotto:\nNon ci sono file associati a questo prodotto.", "domain": "chemistry", "round": 3} +{"url": "https://www.rndsystems.com/products/human-growth-hormone-antibody-178902_mab1067", "date": "2018-05-28T10:05:44Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-22/segments/1526794872766.96/warc/CC-MAIN-20180528091637-20180528111637-00388.warc.gz", "language_score": 0.8783152103424072, "token_count": 1034, "dump": "CC-MAIN-2018-22", "global_id": "webtext-fineweb__CC-MAIN-2018-22__0__161412052", "lang": "en", "text": "Measured by its ability to neutralize Growth Hormone-induced proliferation in the Nb2‑11 rat lymphoma cell line. Bozzola, M. et al. (1998) J. Endocrinol. Invest. 21:65. The Neutralization Dose (ND50) is typically 2-8 µg/mL in the presence of 0.2 ng/mL Recombinant Human Growth Hormone.\nPlease Note: Optimal dilutions should be determined by each laboratory for each application.\nare available in the Technical Information section on our website.\nDetection of Human Growth Hormone by Western Blot.\nWestern blot shows lysates of human pituitary gland tissue. PVDF membrane was probed with 2 µg/mL of Mouse Anti-Human Growth Hormone Monoclonal Antibody (Catalog # MAB1067) followed by HRP-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # HAF018). A specific band was detected for Growth Hormone at approximately 22 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.\nCell Proliferation Induced by Growth Hormone and Neutralization by Human Growth Hormone Antibody.\nRecombinant Human Growth Hormone (Catalog # 1067-GH) stimulates proliferation in the Nb2‑11 rat lymphoma cell line in a dose-dependent manner (orange line). Proliferation elicited by Recombinant Human Growth Hormone (0.2 ng/mL) is neutralized (green line) by increasing concentrations of Mouse Anti-Human Growth Hormone Monoclonal Antibody (Catalog # MAB1067). The ND50 is typically 2-8 µg/mL.\nPreparation and Storage\nReconstitute at 0.5 mg/mL in sterile PBS.\nReconstitution Buffer Available\nThe product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C\nStability & Storage\nUse a manual defrost freezer and avoid repeated freeze-thaw cycles.\n12 months from date of receipt, -20 to -70 °C as supplied.\n1 month, 2 to 8 °C under sterile conditions after reconstitution.\n6 months, -20 to -70 °C under sterile conditions after reconstitution.\nBackground: Growth Hormone\nGrowth hormone (GH), also known as somatotropin, is a member of a family of growth factors that includes prolactin, placental lactogens, proliferins, and somatolactin (1, 2). It is synthesized primarily by somatotropes in the anterior pituitary and is stored in secretary granules. The pulsatile release of GH into circulation is regulated by the concerted actions of the hypothalamic hormones, GH-releasing hormone (GHRH) and somatostatin (SST), as well as by signals from the periphery, ghrelin (3) and leptin (4). The human GH cDNA encodes a 217 amino acid (aa) precursor protein with a 26 aa putative signal peptide. By alternative splicing, at least four isoforms of GH have been identified (5). Human GH is a pleiotropic cytokine that exerts its biological actions by binding to the transmembrane GH receptor, which is present in many cell types (1, 2). GH stimulates the liver and other tissues to produce IGF-I, which regulates growth and metabolism. GH has also been shown to have direct effects on growth that is independent of IGF-I. GH, directly or indirectly via IGF-I, can act on B cells, T cells, NK cells, macrophages, and neutrophils to exert immunomodulatory activities (6). In addition, GH can act directly on various cell types to induce lipolysis, lactation, amino acid uptake, and protein synthesis (1, 2, 6).\nGoffin, V. et al. (1996) Endocrine Rev. 17:385.\nLe Roith, D. et al. (2001) Endocrine Rev.22:53.\nKojima, K. et al. (1999) Nature 402:656.\nTannenbaum, G. et al. (1998) Endocrinol. 139:3871.\nWelniak, L.A. et al. (2002)J. Leukoc. Biol. 71:381.\nSubmit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.", "domain": "chemistry", "round": 3} +{"url": "https://www.cellsignal.com/products/primary-antibodies/phospho-c-kit-tyr719-antibody/3391", "date": "2020-07-14T21:28:32Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-29/segments/1593657151761.87/warc/CC-MAIN-20200714212401-20200715002401-00253.warc.gz", "language_score": 0.8492233157157898, "token_count": 706, "dump": "CC-MAIN-2020-29", "global_id": "webtext-fineweb__CC-MAIN-2020-29__0__146503012", "lang": "en", "text": "Western blot analysis of extracts from MO7e cells, untreated or stimulated with SCF #9907 (50 ng/ml for 2 minutes), using Phospho-c-Kit (Tyr719) Antibody (upper) or c-Kit Antibody #3392 (lower).\n|MW (kDa)||120, 145|\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.\nFor western blots, incubate membrane with diluted primary antibody in 5% w/v BSA, 1X TBS, 0.1% Tween® 20 at 4°C with gentle shaking, overnight.\nNOTE: Please refer to primary antibody product webpage for recommended antibody dilution.\nFrom sample preparation to detection, the reagents you need for your Western Blot are now in one convenient kit: #12957 Western Blotting Application Solutions Kit\nNOTE: Prepare solutions with reverse osmosis deionized (RODI) or equivalent grade water.\nLoad 20 µl onto SDS-PAGE gel (10 cm x 10 cm).\nNOTE: Volumes are for 10 cm x 10 cm (100 cm2) of membrane; for different sized membranes, adjust volumes accordingly.\n* Avoid repeated exposure to skin.\nposted June 2005\nrevised June 2020\nProtocol Id: 10\nPhospho-c-Kit (Tyr719) Antibody detects endogenous levels of c-Kit only when phosphorylated at tyrosine 719. The antibody cross-reacts with tyrosine-phosphorylated PDGF receptor.\nPolyclonal antibodies are produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Tyr719 of mouse c-Kit. Antibodies are purified by protein A and peptide affinity chromatography.\nc-Kit is a member of the subfamily of receptor tyrosine kinases that includes PDGF, CSF-1, and FLT3/flk-2 receptors (1,2). It plays a critical role in activation and growth in a number of cell types including hematopoietic stem cells, mast cells, melanocytes, and germ cells (3). Upon binding with its stem cell factor (SCF) ligand, c-Kit undergoes dimerization/oligomerization and autophosphorylation. Activation of c-Kit results in the recruitment and tyrosine phosphorylation of downstream SH2-containing signaling components including PLCγ, the p85 subunit of PI3 kinase, SHP2, and CrkL (4). Molecular lesions that impair the kinase activity of c-Kit are associated with a variety of developmental disorders (5), and mutations that constitutively activate c-Kit can lead to pathogenesis of mastocytosis and gastrointestinal stromal tumors (6). Tyr719 is located in the kinase insert region of the catalytic domain. c-Kit phosphorylated at Tyr719 binds to the p85 subunit of PI3 kinase in vitro and in vivo (7).\nExplore pathways + proteins related to this product.\nCell Signaling Technology is a trademark of Cell Signaling Technology, Inc.", "domain": "chemistry", "round": 3} +{"url": "http://ukassignmentgeof.hyve.me/anaerobic-resynthesis.html", "date": "2018-08-17T03:08:30Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-34/segments/1534221211664.49/warc/CC-MAIN-20180817025907-20180817045907-00437.warc.gz", "language_score": 0.8623287677764893, "token_count": 634, "dump": "CC-MAIN-2018-34", "global_id": "webtext-fineweb__CC-MAIN-2018-34__0__110459590", "lang": "en", "text": "1 am j physiol 1972 apr222(4):1021-6 high-energy phosphate resynthesis from anaerobic glycolysis in frog gastrocnemius muscle cerretelli p, di prampero pe. Aerobic vs anaerobic glycolysis definition virtually all tissues have a requirement for glucose to function normally glycolysis is the major pathway of glucose. Atp resynthesis equation date:29112016, 06:59 therefore the body relies on anaerobic processes for the first couple of minutes the primary function. The hydrolysis and resynthesis of atp is thus a circular process—atp is hydrolyzed into adp and p i it is anaerobic, or oxygen-independent. Anaerobic resynthesis the hydrolysis and resynthesis of atp is thus a circular process—atp is hydrolyzed into adp and pi, and then adp and pi combine to.\nStart studying chapter 6: energy transfer in the body contains the pathways for atp production from the anaerobic some energy for atp resynthesis also. The aerobic system of atp resynthesis syercollege loading how to gain muscle - aerobic vs anaerobic exercises. The 100-meter sprint is a brief, explosive event the marathon is a prolonged, high-intensity, endurance event. Glycolysis simply means the breakdown (lysis) of glucose and consists of a series of chemical reactions that are controlled by enzymes think of the anaerobic.\nStart studying energy systems learn allowing more energy for atp resynthesis to be the anaerobic glycolysis system provides energy for the resynthesis. Muscle energy and metabolism • muscles shift to anaerobic fermentation – muscles obtain glucose from blood or muscle fiber’s stored glycogen deposits. Atp and heat production in human skeletal muscle during dynamic exercise: higher efficiency of anaerobic than aerobic atp resynthesis.\nThe aerobic system accesses a massive store of virtually unlimited energy on this page you'll learn how this system will keep you chugging along forever without ever. Anaerobic resynthesis 15, 2013 vigrx plus vs xanogen for sale one of the very best companies to 1: counterfeit vigrx plus promotional mla handbook writers research. Carbohydrate metabolism 21 overview of glucose metabolism in the cytosol atp resynthesis from the anaerobic catabolism of glycogen is termed glycolysis.\n- Diagnostics of anaerobic power and capacity regard to tests for the assessment of anaerobic power and capacity, however maximal lactic atp resynthesis.\n- The three primary energy pathways explained by christopher gagliardi on anaerobic glycolysis does not require oxygen and uses the energy contained in glucose.\nBioenergetic systems are metabolic processes that relate to the and anaerobic the energy for atp resynthesis comes from three different series of chemical. I'll start this anaerobic resynthesis section with that silly question learn bond market research paper how to use thresholds to evaluate and train athletes.", "domain": "chemistry", "round": 3} +{"url": "https://www.creative-diagnostics.com/Anti-RCOR2-PAb-193904-147.htm", "date": "2019-01-21T09:25:37Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-04/segments/1547583771929.47/warc/CC-MAIN-20190121090642-20190121112642-00187.warc.gz", "language_score": 0.717147171497345, "token_count": 387, "dump": "CC-MAIN-2019-04", "global_id": "webtext-fineweb__CC-MAIN-2019-04__0__61039925", "lang": "en", "text": "Anti-RCOR2 polyclonal antibody (DPABH-28639)\nRabbit anti-Mouse RCOR2 (aa 277-326) polyclonal antibody for WB\nBring this labeled antibody directly to your bench!\nAdd to basket\nSynthetic peptide, corresponding to C terminal amino acids 277-326 (PPEANTKFNS RWTTDEQLLA VQAIRRYGKD FGAIAEVIGN KTLTQVKTF) of Mouse CoREST2/ RCOR2 (NP_473389).\nWB: 1 μg/ml.\n*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.\nRCOR2; REST corepressor 2; 1A13; Rcor; Rcor1; CoREST\nHave you cited DPABH-28639 in a publication? Let us know\nand earn a reward for your research.\nLee, MG; Wynder, C; et al. An essential role for CoREST in nucleosomal histone 3 lysine 4 demethylation. NATURE 437:432-435(2005).\nRockowitz, S; Lien, WH; et al. Comparison of REST Cistromes across Human Cell Types Reveals Common and Context-Specific Functions. PLOS COMPUTATIONAL BIOLOGY 10:-(2014).\nCustom Antibody Labeling\nWe offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody.", "domain": "chemistry", "round": 3} +{"url": "https://www.cheric.org/research/tech/periodicals/view.php?seq=659292", "date": "2021-12-02T01:34:54Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-49/segments/1637964361064.58/warc/CC-MAIN-20211201234046-20211202024046-00082.warc.gz", "language_score": 0.9195914268493652, "token_count": 272, "dump": "CC-MAIN-2021-49", "global_id": "webtext-fineweb__CC-MAIN-2021-49__0__141497155", "lang": "en", "text": "Biochemical and Biophysical Research Communications, Vol.333, No.2, 411-417, 2005\nIdentification of the human DEAD-box protein p68 as a substrate of Tlk1\nThe activity of the human protein kinase Tlk1 is down-regulated within minutes after exposure of cells to ionizing radiation. In order to identify signaling pathways which might be relevant in the radiation response of mammalian cells we screened nuclear proteins for substrates of Tlk1. Among several proteins one could be identified as p68 RNA helicase. Furthermore, it could be shown that Tlk1 phosphorylates immunoprecipitated p68. The phosphorylation of the C-terminal fragment of p68 by rTlk1 reduced its affinity to single stranded RNA in a gel shift assay. In addition, it could be demonstrated that increasing the Tlk1 activity in HT1080 cells by forced Tlk1 overexpression leads to an increased phosphorylation of endogenous p68, arguing that p68 might be a physiological substrate of Tlk1. These findings open the possibility that Tlk1 might participate in diverse biologic functions like cell growth and differentiation, pre-mRNA splicing, and transcriptional coactivation. (c) 2005 Elsevier Inc. All rights reserved.", "domain": "chemistry", "round": 3} +{"url": "https://www.berstructuralbioportal.org/2017/09/29/precise-control-of-neutron-contrast-in-surfactant-micelles-provides-platform-for-membrane-structure-studies/", "date": "2018-12-16T13:51:21Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-51/segments/1544376827727.65/warc/CC-MAIN-20181216121406-20181216143406-00378.warc.gz", "language_score": 0.7857885956764221, "token_count": 280, "dump": "CC-MAIN-2018-51", "global_id": "webtext-fineweb__CC-MAIN-2018-51__0__221921129", "lang": "en", "text": "Scientists in this study have successfully demonstrated the ability to manipulate the neutron contrast of detergent micelles by incorporating a similar detergent with deuterium-labelled alkyl chains. The presence of excess detergent micelle scattering often has a detrimental influence on scattering data obtained for membrane protein–detergent complexes. Isolation of the scattering signal from the protein of interest can be accomplished by eliminating all scattering from the detergent. Using this approach enabled determination of the overall structure and oligomeric state of a small membrane protein enzyme.\nOliver, R. C., et al. “Designing Mixed Detergent Micelles for Uniform Neutron Contrast.” The Journal of Physical Chemistry Letters8(20), 5041–5046 (2017). [DOI:10.1021/acs.jpclett.7b02149].\nInstruments and Facilities Used: Small angle neutron scattering (SANS): Bio-SANS beamline (CG3) of the High-Flux Isotope Reactor at Oak Ridge National Laboratory (ORNL). Recorded scattering data using MantidPlot software. Neutron contrast studies: ModULes for the Analysis of Contrast (MULCh) Variation Data at University of Sydney (smb-research.smb.usyd.edu.au/NCVWeb/).", "domain": "chemistry", "round": 3} +{"url": "https://medandaily.com/27407320/radiocarbon-dating-false/", "date": "2020-10-25T11:28:49Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-45/segments/1603107888931.67/warc/CC-MAIN-20201025100059-20201025130059-00577.warc.gz", "language_score": 0.9442927241325378, "token_count": 652, "dump": "CC-MAIN-2020-45", "global_id": "webtext-fineweb__CC-MAIN-2020-45__0__70402015", "lang": "en", "text": "Instead of these include radiometric dating is very limited to date? Are set to date is set to determine the grotte du renne controversy in the earth when radioactive elements have thought that carbon dating. This week responded to about radiocarbon dating to. Org internet news portal provides absolute dates in order for that Go Here whole. Scientists can easily establish that dinosaurs and c14 dating errors. But since some technical detail how carbon dating is very accurate? A new study out of their accuracy and the oldest sample for carbon dating, a study out this process. Archaeologists routinely use to determine the first place, radiocarbon dating method was flawed? Response: i didn't see any significant geologic events in this dating method? It a study out of known age of carbon-12 to objects only interested in. Dating technique called radiometric dating, scientists say that your whole. It is approximately 300 to learn about how evolutionists use a discussion on archaeological materials – wood. Radiometric dating uses the carbon dating of 1260–1390 ad, south africa.\nCollagen, is well as rocks click to read more accurate age of the. Scientists calculate the ultimate benchmark of determining an ancient. Centuries later established that time period or other than traditional dating. Org internet news portal provides absolute dates are under the method's false, which coincides with. Do all scientists can easily establish that contains the method of the earth when the most famous absolute dates received from the age of archaeological. Radiometric dating to determine the age via independent methods that assumption is 1 too much daughter. While doing so the radiocarbon dating method as rubidium/strontium, we will explain how. Radiometric dating has been circulated by the carbon dating. Since the standards associated with the use of the various other objects that the deviations from solidified lava. Pdf the services provided superior and, is the. Carbon dating accurate - carbon suitable for a lot of the shroud was in the radiocarbon dating. Radiometric dating rocks from the age detection is used to date? It's accuracy of isotope series, we dated and the shroud was in the application of giving https://medandaily.com/ However, i asked several people who have used to false?\nWould find single woman in the calculations based. Centuries later established that the accuracy of the absolute dating, archaeometry 50.2: i recommend you? Worse still, we must know what is it would make no argon, this paper discloses the ratio of assertion 1 too much daughter. Eventually, radiometric dating the 1988, identify vintages of geologic. That carbon dating bug you want to 5 billion years ago. Eventually, radiocarbon dated samples generally requires calibration of ostecalcin.\nBut since some technical detail how carbon dating. Bt, radiometric dating is radiometric dating compares the dates in or high-tech the radiocarbon dating are under the luna tree, the method's false. Geologists do you the solar system formed from a sample for those who know how. Define radiometric dating method, explained two types of rocks by. Radiocarbon dating to determine of bone: the shroud to.", "domain": "chemistry", "round": 3} +{"url": "http://www.qualitybiological.com/ptistore/control/product?prodId=P659-40024", "date": "2013-05-25T16:44:39Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2013-20/segments/1368705976722/warc/CC-MAIN-20130516120616-00045-ip-10-60-113-184.ec2.internal.warc.gz", "language_score": 0.8339717984199524, "token_count": 330, "dump": "CC-MAIN-2013-20", "global_id": "webtext-fineweb__CC-MAIN-2013-20__0__84118522", "lang": "en", "text": "Pronto!T Validation Kit for 10 Reactions\nThis Pronto!T Universal Validation Kit allows you to test the complete Pronto!T Universal Microarray Reagent system in your laboratory (10 reactions). The system offers a special Pre-Soak step that reduces any problematic background you might have due to long-term storage. The spotting solution is optimized for both long oligonucleotides and cDNA and shows reduced evaporation during extended print runs. Spots are consistently circular and show even, smooth distribution of the DNA. -Kit includes all the components you need from UltraGAPST slides through hybridization wash solutions. -Optimized for printing both long oligonucleotide and cDNA microarrays. -Reproducible with interslide CVs under 10%. -Proprietary spotting solution for consistent spot morphology and less than 10% evaporation over extended print runs. -New Pre-Soak step reduces background significantly. -Hybridization reagents include accelerants and volume excluders that enhance sensitivity. -Up to 9 month storage at room temperature. -The kit includes: -15mL Universal Spotting Solution. -10 UltraGAPST Slides. -200mL Pre-Soak Solution. -2mL Borohydride Solution. -200mL Pre-Hybridization Solution. -1mL Short Oligo Hybridization Solution. -1mL Long Oligo / cDNA Hybridization Solution. -150mL Wash Reagent A. -15mL Wash Reagent B\nList prices starting at $442.40 each.\nAdd To Cart", "domain": "chemistry", "round": 3} +{"url": "https://repository.ipb.ac.id/handle/123456789/12926", "date": "2021-05-07T02:10:41Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-21/segments/1620243988774.18/warc/CC-MAIN-20210506235514-20210507025514-00170.warc.gz", "language_score": 0.9097404479980469, "token_count": 378, "dump": "CC-MAIN-2021-21", "global_id": "webtext-fineweb__CC-MAIN-2021-21__0__65865736", "lang": "en", "text": "Hematological and Histopathological Organs Studies on Quinine Induced Rat as Metabolic Potential Test of Angkak.\nMetadataShow full item record\nThis research was purposed to analyze potency of angkak on hematological parameters and organs recovery in quinine induced rat. Rats were randomly divided into five groups. Group I were given orally aquades, group II received 100 g/kg bb quinine 14 day afterward not received angkak, group III received 100 g/kg bb quinine 14 day afterward received 0.04 g/kg bb angkak 14 day, group IV received 100 g/kg bb quinine afterward received 0.08 g/kg bb angkak, and group V not received quinine afterward received 0.04 g/kg bb angkak. Hematology analysis measured every 3 day. At 29 th day, the rats were necropsied to see the lesion on the liver and kidney both macroscopically and microscopically. The treatment with angkak can increasing the body weight of the rats (p<0.05). Analysis result of platelet showed that treatment using 0.04 g/kg bb angkak able to increase the sum of platelets (p<0.05). The treatment using angkak have not demonstrated significantly effect on red blood cell, hemoglobin, and hematocrit (p>005). Observation histopathology of the test animals liver and kidney showed the treatment using 0.04 g/kg bb and 0.08 g/kg bb angkak was confirmed helping the liver and kidney to recover from histopathology lesion caused negative effect. Statistical analysis result showed that recover using angkak is differently significant.\n- UT - Biochemistry", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/Aspartate-Aminotransferase-antibody-EPR12145-ab170950.html", "date": "2018-09-20T01:22:56Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-39/segments/1537267156314.26/warc/CC-MAIN-20180919235858-20180920015858-00486.warc.gz", "language_score": 0.869592547416687, "token_count": 649, "dump": "CC-MAIN-2018-39", "global_id": "webtext-fineweb__CC-MAIN-2018-39__0__94185372", "lang": "en", "text": "Synthetic peptide within Human Aspartate Aminotransferase aa 150-250 (Cysteine residue). The exact sequence is proprietary. Database link: P17174\nHepG2; MCF-7, HT-29 and K562 cell lysates; Human hepatocellular carcinoma tissue; HepG2 and K562 cells.\nMouse brain, rat brain and rat heart lysates.\nHuman glioma tissue, K562.\nOur RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents\nWe are constantly working hard to ensure we provide our customers with best in class antibodies. As a result of this work we are pleased to now offer this antibody in purified format. We are in the process of updating our datasheets. The purified format is designated 'PUR' on our product labels. If you have any questions regarding this update, please contact our Scientific Support team.\nThis product is a recombinant rabbit monoclonal antibody.\nShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.\nImmunocytochemistry/Immunofluorescence analysis of HT-29 (human colorectal adenocarcinoma) cells labelling Aspartate Aminotransferase with purified ab170950 at 1/120. Cells were fixed with 100% methanol. An Alexa Fluor® 488-conjugated goat anti-rabbit IgG (ab150077) at 1/1000 dilution was used as the secondary antibody. Nuclei counterstained with DAPI (blue).\nSecondary Only Control: PBS was used instead of the primary antibody as the negative control.\nFlow Cytometry analysis of K-562 (Human chronic myelogenous leukemia lymphoblast) cells labeling Aspartate Aminotransferase with purified ab170950 at 1:20 dilution (red). Cells were fixed with 4% Paraformaldehyde. A Goat anti rabbit IgG (Alexa Fluor ® 488) secondary antibody was used at 1:2000 dilution. Isotype control - Rabbit monoclonal IgG (Black). Unlabeled control - Cell without incubation with primary antibody and secondary antibody (Blue).\nImmunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human glioma tissue sections labeling Aspartate aminotransferase with Purified ab170950 at 1:170 dilution. Heat mediated antigen retrieval was performed using ab93684 (Tris/EDTA buffer, pH 9.0). Tissue was counterstained with Hematoxylin. ImmunoHistoProbe one step HRP Polymer (ready to use) secondary antibody was used at 1:0 dilution. PBS instead of the primary antibody was used as the negative control.", "domain": "chemistry", "round": 3} +{"url": "https://psychology.fandom.com/wiki/Barbital", "date": "2022-05-18T12:16:00Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-21/segments/1652662522270.37/warc/CC-MAIN-20220518115411-20220518145411-00044.warc.gz", "language_score": 0.7573952674865723, "token_count": 1362, "dump": "CC-MAIN-2022-21", "global_id": "webtext-fineweb__CC-MAIN-2022-21__0__319146648", "lang": "en", "text": "Individual differences |\nMethods | Statistics | Clinical | Educational | Industrial | Professional items | World psychology |\nBiological: Behavioural genetics · Evolutionary psychology · Neuroanatomy · Neurochemistry · Neuroendocrinology · Neuroscience · Psychoneuroimmunology · Physiological Psychology · Psychopharmacology (Index, Outline)\nBarbital chemical structure\n|ATC code |\n|Molecular weight||184.193 g/mol|\n|Routes of administration||Oral|\nBarbital (marketed under the brand name Veronal), also called barbitone, was the first commercially marketed barbiturate. It was used as a sleeping aid (hypnotic) from 1903 until the mid-1950s. The chemical names for barbital are diethylmalonyl urea or diethylbarbituric acid. Its chemical formula is (C2H5)2C~CO NH]ICO (sodium 5,5-diethyl barbiturate). Veronal was prepared by condensing diethylmalonic ester with urea in the presence of sodium ethylate, or by adding ethyl iodide to the silver salt of malonylurea. The result was an odorless, slightly bitter, white crystalline powder.\nBarbital was first synthesized in 1902 by German chemists Emil Fischer and Joseph von Mering. They published their discovery in 1903 and it was marketed in 1904 by the Bayer company as “Veronal”. A soluble salt of barbital was marketed by the Schering company as “Medinal.” It was dispensed for “insomnia induced by nervous excitability”. It was provided in either capsules or cachets. The therapeutic dose was ten to fifteen grains (0.65-0.97 grams). 3.5 to 4.4 grams is the deadly dose but sleep has also been prolonged up to ten days with recovery.\nVeronal was considered to be a great improvement over the existing hypnotics. Its taste was slightly bitter, but an improvement over the strong, unpleasant taste of the commonly used bromides. It had few side effects. Its therapeutic dose was far below the toxic dose. However, prolonged usage resulted in tolerance to the drug, requiring higher doses to reach the desired effect. Fatal overdoses of this slow acting hypnotic were not uncommon.\n- Fischer, Emil and Joseph von Mering, “Ueber eine neue Klasse von Schlafmitteln”, Therap Gegenw 44:97-101, 1903.\n- \"Veronal\", in Finley, Ellingwood, M.D. The American Materia Medica, Therapeutics and Pharmacognosy\", 1919. , accessed 07 Nov 2005.\n- \"Emma Zunz\" by Jorge Luis Borges (short story)\nAllobarbital, Amobarbital, Aprobarbital, Barbexaclone, Barbital, Butabarbital, Butalbital, Butobarbital, Cyclobarbital, Ethallobarbital, Heptabarbital, Hexobarbital, Mephobarbital, Metharbital, Methohexital, Methylphenobarbital, Pentobarbital, Phenobarbital, Primidone, Proxibarbal, Reposal, Secobarbital, Talbutal, Thiobarbital, Thiopental, Vinbarbital, Vinylbital\nPsycholeptics: hypnotics and sedatives (N05C)\n|Barbiturates||Pentobarbital - Amobarbital - Butobarbital - Barbital - Aprobarbital - Secobarbital - Talbutal - Vinylbital - Vinbarbital - Cyclobarbital - Heptabarbital - Reposal - Methohexital - Hexobarbital - Thiopental Ethallobarbital - Allobarbital - Proxibarbal - Phenobarbital|\n|Aldehydes||Chloral hydrate - Chloralodol - Acetylglycinamide chloral hydrate - Dichloralphenazone - Paraldehyde|\n|Benzodiazepine||Flurazepam - Nitrazepam - Temazepam - Flunitrazepam - Nimetazepam - Estazolam - Triazolam - Lormetazepam - Midazolam - Brotizolam - Quazepam - Loprazolam - Doxefazepam - Cinolazepam|\n|Piperidinedione||Glutethimide - Methyprylon - Pyrithyldione|\n|Nonbenzodiazepine||Zopiclone/Eszopiclone - Zolpidem - Zaleplon|\n|Melatonin receptor||Melatonin - Ramelteon|\n|Other||Methaqualone - Clomethiazole - Bromisoval - Carbromal - Scopolamine - Propiomazine - Triclofos - Ethchlorvynol - Valerian - Hexapropymate - Bromides - Apronal - Valnoctamide - Methylpentynol - Niaprazine - Dexmedetomidine|\nThis article incorporates text from the Encyclopædia Britannica, Eleventh Edition, a publication now in the public domain.\n|This page uses Creative Commons Licensed content from Wikipedia (view authors).|", "domain": "chemistry", "round": 3} +{"url": "https://pure.ewha.ac.kr/en/publications/mammary-excretion-and-placental-transfer-of-cis-malonato4r5r-45-b", "date": "2023-06-06T20:04:16Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-23/segments/1685224653071.58/warc/CC-MAIN-20230606182640-20230606212640-00090.warc.gz", "language_score": 0.8594328165054321, "token_count": 435, "dump": "CC-MAIN-2023-23", "global_id": "webtext-fineweb__CC-MAIN-2023-23__0__300868587", "lang": "en", "text": "The mammary excretion and placental transfer of cis-malonato[(4R, 5R)-4,5-bis(aminomethyl)-2-isopropyl-1,3-dioxolane]platinum(II) (CAS 146665-77-2, SKI 2053R), a new potential anticancer agent, were investigated in the lactating or pregnant rats after a single intravenous administration of 14C-SKI 2053R (20 mg/kg, 100 μCi/kg). The radioactivity of the milk declined in a biexponential fashion with an initial half-life of 0.39 h and with a terminal half-life of 14.05 h in the lactating rats. The radioactivity of the milk was lower than that of plasma until 1 h after dosing, but was higher than that of plasma from 4 h after dosing. 14C-SKI 2053R was well distributed to most tissues including uterus and placenta in the pregnant rats, but the levels of radioactivity in the amniotic fluid and fetuses were markedly lower than that in the maternal plasma. Therefore, it is concluded that SKI 2053R scarcely passes the blood-placenta barrier, which was confirmed by the whole-body autoradiography study.\n|Number of pages||5|\n|State||Published - 1996|\n- anticancer agent\n- CAS 146665-77-2\n- cis-malonato[(4R,5R)-4,5-bis(aminomethyl)-2-iso-propyl-1,3 -dioxolane]platinum(II)\n- SKI 2053R, 14C-labelled, mammary excretion, placental transfer", "domain": "chemistry", "round": 3} +{"url": "http://www.diva-portal.org/smash/record.jsf?pid=diva2:844987", "date": "2016-10-22T19:56:58Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2016-44/segments/1476988719041.14/warc/CC-MAIN-20161020183839-00222-ip-10-171-6-4.ec2.internal.warc.gz", "language_score": 0.8826732635498047, "token_count": 445, "dump": "CC-MAIN-2016-44", "global_id": "webtext-fineweb__CC-MAIN-2016-44__0__255148128", "lang": "en", "text": "High-abundant protein depletion strategies applied on dog cerebrospinal fluid and evaluated by high-resolution mass spectrometry\n2015 (English)In: Biochemistry and Biophysics Reports, ISSN 2405-5808, Vol. 3, 68-75 p.Article in journal (Refereed) Published\nAs the number of fully sequenced animal genomes and the performance of advanced mass spectrometry-based proteomics techniques are continuously improving, there is now a great opportunity to increase the knowledge of various animal proteomes. This research area is further stimulated by a growing interest from veterinary medicine and the pharmaceutical industry. Cerebrospinal fluid (CSF) is a good source for better understanding of diseases related to the central nervous system, both in humans and other animals. In this study, four high-abundant protein depletion columns, developed for human or rat serum, were evaluated for dog CSF. For the analysis, a shotgun proteomics approach, based on nanoLC-LTQ Orbitrap MS/MS, was applied. All the selected approaches were shown to deplete dog CSF with different success. It was demonstrated that the columns significantly improved the coverage of the detected dog CSF proteome. An antibody-based column showed the best performance, in terms of efficiency, repeatability and the number of proteins detected in the sample. In total 983 proteins were detected. Of those, 801 proteins were stated as uncharacterized in the UniProt database. To the best of our knowledge, this is the so far largest number of proteins reported for dog CSF in one single study.\nPlace, publisher, year, edition, pages\n2015. Vol. 3, 68-75 p.\nCerebrospinal fluid, Dog, High-abundant protein depletion, Shotgun proteomics, Orbitrap, Mass spectrometry\nIdentifiersURN: urn:nbn:se:uu:diva-259611DOI: 10.1016/j.bbrep.2015.07.013OAI: oai:DiVA.org:uu-259611DiVA: diva2:844987", "domain": "chemistry", "round": 3} +{"url": "https://www.creative-diagnostics.com/Anti-Human-Thyroid-Stimulating-Hormone-Antibody-57463-490.htm", "date": "2019-03-27T00:45:13Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-13/segments/1552912207146.96/warc/CC-MAIN-20190327000624-20190327022624-00318.warc.gz", "language_score": 0.7423557043075562, "token_count": 341, "dump": "CC-MAIN-2019-13", "global_id": "webtext-fineweb__CC-MAIN-2019-13__0__124286887", "lang": "en", "text": "Anti-Thyroid Stimulating Hormone polyclonal antibody (DPAB2416)\nRabbit Anti-Human Thyroid Stimulating Hormone polyclonal antibody for IHC, ICC, RIA, IHC-P\nBring this labeled antibody directly to your bench!\nAdd to basket\nPurified human TSH\n*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.\nHCG; LHA; FSHA; Tsha; aGSU; GPHA1\nHave you cited DPAB2416 in a publication? Let us know\nand earn a reward for your research.\nJeziorowski, T; Watanabe, T; et al. Heterogeneity of pituitary gonadotrope cells in male rats. ARCHIVES OF HISTOLOGY AND CYTOLOGY 60:355-370(1997).\nYOO, SH; LIM, DJ; et al. UBIQUITOUS PRESENCE OF CHROMOGRANIN-A IN THE INNER-EAR OF GUINEA-PIG. FEBS LETTERS 317:113-117(1993).\nCustom Antibody Labeling\nWe offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody.", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/caspr3-antibody-ab198853.html", "date": "2019-12-05T20:24:13Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-51/segments/1575540482038.36/warc/CC-MAIN-20191205190939-20191205214939-00293.warc.gz", "language_score": 0.6529834270477295, "token_count": 366, "dump": "CC-MAIN-2019-51", "global_id": "webtext-fineweb__CC-MAIN-2019-51__0__1193546", "lang": "en", "text": "Product nameAnti-CASPR3 antibody\nSee all CASPR3 primary antibodies\nDescriptionRabbit polyclonal to CASPR3\nTested applicationsSuitable for: IHC-Pmore details\nSpecies reactivityReacts with: Human\nSynthetic peptide corresponding to Human CASPR3. (Near the C terminal; NP_387504).\nDatabase link: Q9BZ76\n- Human lymphoma and lung cancer tissues.\nStorage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.\nStorage bufferpH: 7.3\nPreservative: 0.05% Sodium azide\nConstituents: 50% Glycerol, 49% PBS\nConcentration information loading...\nPurityImmunogen affinity purified\nOur Abpromise guarantee covers the use of ab198853 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\n|IHC-P||1/25 - 1/100.|\nSequence similaritiesBelongs to the neurexin family.\nContains 2 EGF-like domains.\nContains 1 F5/8 type C domain.\nContains 1 fibrinogen C-terminal domain.\nContains 4 laminin G-like domains.\nCellular localizationSecreted and Cell membrane.\n- Information by UniProt\n- CASPR3 antibody\n- Cell recognition molecule Caspr3 antibody\n- CNTNAP3 antibody\nab198853 has not yet been referenced specifically in any publications.", "domain": "chemistry", "round": 3} +{"url": "https://innspub.net/study-of-biochemical-and-phytochemical-parameters-in-local-variety-of-barley-hordeum-vulgare-under-saline-conditions/", "date": "2023-05-28T07:20:38Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-23/segments/1685224643585.23/warc/CC-MAIN-20230528051321-20230528081321-00336.warc.gz", "language_score": 0.7236171960830688, "token_count": 1788, "dump": "CC-MAIN-2023-23", "global_id": "webtext-fineweb__CC-MAIN-2023-23__0__250431178", "lang": "en", "text": "Int. J. Biosci.16( 1), 427-434, January 2020\nCurrent research targeted to measure the effect of increasing concentration of (0-200mM) of KCl2 and MgCl2 salt on Hordeum vulgare cultivars, (Jow 83, and Jow 87). Overall, increasing of KCl2 and MgCl2 stress reduced leaf pigments in both cultivars significantly, with a lesser extent in Jow 83 as compared to Jow 87. The present results justify that a significantly (p<0.05 continuously decrease of total sugars, total proteins, antioxidant activity, reducing sugar, phenolic compounds, with increasing of concentration of KCl2 and MgCl2 as compared to control plants. While significantly (p<0.05) increased amount of Proline contents in both cultivars with increasing of salt concentrations as compared to control. Various salt-treated plants showed a decreased amount of various biochemical and phytochemical as compared with control plants. The Jow 87 salt tolerance nature was correlated positively with its better performance in terms of physiological, phytochemical, and biochemical attributes.\nAcosta-Motos JR, Ortuño MF, Bernal-Vicente A, Diaz-Vivancos P, Sanchez-Blanco MJ, Hernandez JA. 2017. Plant responses to salt stress: adaptive mechanisms. Agronomy 7(1), 18.\nArzani A, Ashraf M. 2016. Smart engineering of genetic resources for enhanced salinity tolerance in crop plants. Critical Reviews in Plant Sciences 35, 146-189.\nBates LS, Waldran RP, Teare ID. 1973. Rapid determination of free proline for water stress studies. Plant Soil 39, 205-208.\nBrandenbury W, Kleir C. 2011. Effect of MgCl2 on germination, growth and biomass allection of the radish CV. “cherry Belle”. American Journal of Environment Science 7, 132-135.\nCakmak I. 2005. The role of potassium in allevisting detrimental effects of abiotic stress in plants. Journal of Plant Nutrition and Soil Science 168, 521-530.\nDanai TS, Kumar V, Shriram V. 2011. Differential Response of two scented Indica Rice (Oryza sativa) Cultivars under salt stress. Journal of Stressphysiology and Biochemistry 7, 387-397.\nDougherty Gk, Smith GR. 2006. Acute effects of road de-icers on the tadpoles of three anurans. Applied herpetology 3, 87-93.\nFlowers TJ, Colmer TD. 2008. Salinity tolerance in halophytes. New Phytologist journal 179, 945-963.\nJiang Q, Roche D, ManacoTA, Durham S. 2006. Gas exchange, chlorophyll fluorescence parameters and carbon isotope discrimination of fourteen barley genetic lines in response to salinity, Field Crops Research 96, 269-278.\nKalaji MH, GurP. 2008. Chlorophyll fluorescence: a useful tool in barley plant breeding programs. In: Sanchez A., Gutierrez S.J. (Eds), photochemistry Research progress. Nova publishers, NY, USA pp. 439-463.\nKamali N, Pour MRK, Soleymani AT. 2014. Studying growth indices and grain yield of barley cultivars at planting dates in Isfahan region. International Journal of Farming and Allied Science 3(1), 35-44.\nKhare T, Desai D, Kumar V. 2012. Effect of MgCl2 stress on germination, plant growth, chlorophyll content, proline content and lipid peroxidation in Sorghum Cultivars. Journal of Stress Physiology and Biochemistry 8(4),\nKim DO, Jeong SW, Lee CY. 2003. Antioxidant capacity of phenolic, phytochemicals from various cultivars of plums. Food Chemistry journal 81(3), 321-326.\nKumar M, Hasan M, Arora A, Gaikwad K, Kumar S, Rai RD, Singh A. 2015. Sodium chloride-induced spatial and temporal manifestation in membrane stability index and protein profiles of contrasting wheat (Triticum aestivum L.) genotypes under salt stress. Indian Journal of Plant Physiology 20(3), 271-275.\nKumar S, Singh A. 2016. Epigenetic regulation of abiotic stress tolerance in plants. Advances in Plants & Agriculture Research 5, 179.\nLichtenthaler HK, Wellburn AR. 1983. Determinations of total carotenoids and chlorophylls a and b of leaf extracts in different solvents. Biochemical Society Transaction 11, 591-592.\nLowry OH, Rosebrough NJ, Farr AL, Randall RJ. 1951. Protein Measurement with the Follin Phenol Reagent. Journal of Biological Chemistry 193, 265-275.\nMachado RMA, Serralheiro RP. 2017. Soil salinity: effect on vegetable crop growth. Management practices to prevent and mitigate soil salinization. Horticulturae 3(2), 30.\nMian A, Oomen RJ, Isayenkov S, Sentenac H, Maathuis FJ, Véry AA. 2011. Over‐expression of an Na+‐and K+‐permeable HKT transporter in barley improves salt tolerance. The Plant Journal 68(3), 468-479.\nMiller GL. 1959. Use of dinitrosalicylic acid reagent for determination of reducing sugar. Analytical Chemistry 31(3), 426-428.\nMontgomery R. 1961. Further studies of the phenol sulphuric acid reagent for carbohydrates. Biochimica Biophysica Acta pp. 591-593.\nPareek A, Sopory SK, Bohnert HJ, Govindjee (Eds). 2010. Abiotic stress adoption in plants. Physiological, molecular and genomic function springer Dordrecht.\nParida AK, Das AB. 2005. Salt tolerance and salinity effects on plants: a review. Ecotoxicol Environ safe 60, 324-349.\nPrieto P, Pineda M, Aguilar M. 1999. Spectrophotometric quantification of antioxidant capacity through the formation of phosphomolybdenum complex, specific application to the determination of vitamin E. Analytical Biochemistry 269(2), 337-341.\nQadir M, Quillérou E, Nangia V, Murtaza G, Singh M, Thomas RJ, Drechsel P, Noble A. 2014. November. Economics of salt‐induced land degradation and restoration. In Natural resources forum 38(4), 282-295.\nSetter TL. 2003. Waters, I. Review of prospects for germplasm improvement for waterlogging tolerance in wheat and barley and oats. Plants Soil 253-1-34.\nShabala S, Hariadi Y. 2005. Effect of magnesium availability on the activity of plasma membrane ion transporters and light induced response from bread bean leaf mesophyll. Planta 221, 56-65.\nShahabaz M, Ashraf M. 2013. Improving salinity tolerance in cereals. Critical Reviews in Plant Sciences 32, 237-249.\nShaukat S. 2103. Production technology of barley (Hordeum vulgare L.) in Pakistan http// pakgrifarming. Blog spot.com/2013/02/ production- technology of barley Hordeum.html\nShrivastava P, Kumar R. 2015. Soil salinity: A serious environmental issue and plant growth promoting bacteria as one of the tools for its alleviation. Saudi Journal of Biological Sciences 22(2), 123-131\nWang M, Zheng Q, Shen Q, Guo S. 2013. The Critical Role of Potassium in Plant Stress Response. International Journal of Molecular Science 14, 7370-7390.\nYasoubi P, Barzegar M, Sahari MA, Azizi MH. 2007. Total phenolic contents and antioxidant activity of Pomegranate (Punica granatum L.) peel extracts. Journal of Agricultural. Science Technology 9, 35-42.", "domain": "chemistry", "round": 3} +{"url": "http://www.scansteel.mx/library/reversible-polymeric-gels-and-related-systems", "date": "2019-03-25T01:48:50Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-13/segments/1552912203547.62/warc/CC-MAIN-20190325010547-20190325032547-00353.warc.gz", "language_score": 0.7118359208106995, "token_count": 1721, "dump": "CC-MAIN-2019-13", "global_id": "webtext-fineweb__CC-MAIN-2019-13__0__8573957", "lang": "en", "text": "By Paul S. Russo\ncontent material: A standpoint on reversible gels and comparable structures / Paul S. Russo --\nViscoelastic habit of extremely excessive molecular weight polyethylene pseudogels / B. Chung and A.E. Zachariades --\nDynamic gentle scattering and brief electrical birefringence research of poly(vinyl chloride) microgels / S.J. Candau, Y. Dormoy, E. Hirsch, P.H. Mutin, and J.M. Guenet --\nfocus dependence of the polymer diffusion coefficient / Wender Wan and Scott L. Whittenburg --\nresults of aggregation and solvent caliber at the viscosity of semidilute poly(vinylbutyral) recommendations / C.W. Paul and P.M. Cotts --\nReversible polymer complexes stabilized via hydrogen bonds / Ilias Iliopoulos, Roland Audebert, and Claude Quivoron --\norganization and gelation of polystyrenes through terminal sulfonate teams / Martin Möller, Jürgen Omeis, and Elke Mühleisen --\nSolvent mobility in atactic polystyrene-toluene structures / Frank D. Blum and Byaporn naNagara --\nactual gelation of a steroid-cyclohexane process : kinetic phenomenological strategy / P. Terech --\nNematic suggestions of rodlike polymers : mild scattering from nematic strategies with advanced texture and part separation in negative solvents / Kazunori Se and G.C. Berry --\nGelation of poly([gamma]-benzyl-[alpha], L-glutamate) / Paul S. Russo, Paul Magestro, and Wilmer G. Miller --\nconstitution formation and section adjustments in options of a inflexible polymer / Yachin Cohen, Herbert H. Frost, and Edwin L. Thomas --\nOrdering and gelation in DNA recommendations / Victor A. Bloomfield --\nThermally reversible gelation of the gelatin-water process / Madeleine Djabourov and Jacques Leblond --\nIn vitro polymerization of complicated cytoplasmic gels / Ralph Nossal --\nThermally reversible hydrogels : swelling features and actions of copoly(N-isopropylacrylamide-acrylamide) gels containing immobilized asparaginase / Liang Chang Dong and Allan S. Hoffman --\nN-isopropylacrylamide and N-acryloxysuccinimide copolymer : a thermally reversible, water-soluble, activated polymer for protein conjugation / Carol-Ann Cole, Sigrid M. Schreiner, John H. Priest, Nobuo Monji, and Allan S. Hoffman --\ndecrease serious resolution temperatures of aqueous copolymers of N-isopropylacrylamide and different N-substituted acrylamides / John H. Priest, Sheryl L. Murray, R. John Nelson, and Allan S. Hoffman --\nPolymer community reports utilizing paramagnetic probes : Cu(II) in cross-linked polyacrylamide gels / Gary C. Rex and Shulamith Schlick.\nRead or Download Reversible Polymeric Gels and Related Systems PDF\nBest polymers & textiles books\nContent material: evaluate ; 1. Nanocomposite and Nanostructured Coatings ; NANOSTRUCTURED fabrics ; 2. Encapsulation of Clay Platelets within Latex debris ; three. Polyurethane-POSS Nanostructured Hybrid Dispersions by way of the Prepolymer blending technique ; four. Nanostructured Conjugated Polymer community Ultrathin movies and Coatings utilizing the Precursor Polymer strategy ; NANOMATERIAL PROCESSING ; five.\nThe training and characterization of recent fabrics with accurately managed macromolecular dimensions, functionalities, and decomposition, in addition to with well-defined topologies, may be the focus of latest polymer synthesis. the simplest keep watch over of molecular features may be accomplished in a controlled/living polymerization -- a sequence progress procedure with no chain breaking reactions.\nIn a multi-billion greenback undefined, caliber, defense and the linked credibility, is of upmost value to pharmaceutical brands and agreement brands and as regards to leachables and extractables (L&E) this has implications for the full polymer provide chain.\nRealizing and predicting the constitution and homes of woven textiles is critical for reaching particular functionality features in quite a few woven functions. Woven textiles are utilized in more than a few items corresponding to clothing, technical and business textiles. Woven fabric constitution: idea and purposes offers complete insurance of the constitution, behaviour, modeling and layout of woven materials and their relevance to the cloth undefined.\n- Materials Handbook\n- High Performance Synthetic Fibers for Composites (Publication (National Research Council (U.S.)), No. 458.)\n- Practical Guide to Structures, Properties and Applications of Styrenic Polymers\n- Principles of Polymer Chemistry\nExtra resources for Reversible Polymeric Gels and Related Systems\nAs seen i n F i g . 5 upon increasing temperature, the normalized f i r s t cumulant increases and the anomalous increase i n the low Κ range appears. Again, i t must be noticed that the extrapolation of <Γ>/2Κ to zero Κ from the high Κ range coïncides with the value of D calculated from transient e l e c t r i c birefringence. 2 3 3 2 2 Q 3 2 3 Q 2 3 2 5 2 Q DISCUSSION The r e s u l t s presented above show that the structure of the aggregates formed by the quenching of PVC solutions depends on the s t a r t i n g concentration.\nThe r a t e of d i f f u s i o n depends o n the c o n c e n t r a t i o n o f the polymer, the tempera t u r e , the p o l y m e r - s o l v e n t i n t e r a c t i o n and t h e c h a r a c t e r i s t i c l e n g t h a s s o c i a t e d w i t h the experiment. To u n d e r s t a n d t h e concept of t h e c h a r a c t e r i s t i c l e n g t h of the measurement c o n s i d e r a t y p i c a l q u a s i e l a s t i c l i g h t s c a t t e r i n g (QELS) experiment. The i n t e n s i t y o f t h e l i g h t s c a t t e r e d by t h e polymer i s a n a l y z e d as a f u n c t i o n of a n g l e between the i n c i d e n t l a s e r beam and the s c a t t e r e d d i r e c t i o n w h i c h i s d e t e r m i n e d by two p i n h o l e s .\nSedlacek, B. In Physical Optics of Dynamic Phenomena and Processes in Macromolecular Systems; Sedlacek, B . , E d . ; W. 353. G. Scaling Concepts in Polymer Physics; Cornell Univ. ), 1979. ; Van Megen, W. J. Chem. Phys. 1984, 80, 3513. RECEIVED January 24, 1987 Chapter 4 Concentration Dependence of the Polymer Diffusion Coefficient 1 Wender Wan and Scott L . ch004 Department of Chemistry, University of New Orleans, New Orleans, LA 70148 A theoretical expression for the concentration dependence of the polymer diffusion coefficient is derived.", "domain": "chemistry", "round": 3} +{"url": "https://scholars.unh.edu/thesis/1619/", "date": "2024-02-23T18:21:55Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707947474440.42/warc/CC-MAIN-20240223153350-20240223183350-00044.warc.gz", "language_score": 0.9188535809516907, "token_count": 348, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__90723525", "lang": "en", "text": "Date of Award\nProgram or Major\nMaster of Science\nJohn M Halstead\nIn the past two decades there has been an increase in detection and awareness of PFAS (Per- or Polyfluoroalkyl substances) chemicals in groundwater and drinking water in the United States. In stark contrast to other known harmful chemical pollutants, little is known yet about the specific epidemiological and toxicological effects of prolonged intake and consumption of PFAS chemicals in environmentally occurring levels. New Hampshire in particular has encountered two high-profile episodes of PFAS contamination with hotspots in Merrimack, NH due to factory pollution and Pease International Tradeport in Portsmouth, NH due to military activity. These instances have brought increased attention to the issue from both the state legislature and residents.The purpose of this study was to ask New Hampshire residents how much they value the removal of PFAS chemicals from their public drinking water systems to reduce the risk of possible negative health outcomes that come with PFAS intake. Using data from a September 2021 online survey of New Hampshire residents and employing the contingent valuation survey method in the form of Willingness-To-Pay, we used several regression techniques, we determined that NH residents are willing to pay an additional $13.07 to their existing water bill to remove the risk of negative health outcomes stemming from PFAS consumption. Throughout the models, the most important confounding factor influencing higher willingness-to-pay values was the presence of moderate or major existing health concerns about drinking tap water.\nPrice, Tristan Colby, \"Economic Valuation of PFAS Remediation in New Hampshire Municipal Drinking Water Systems: A Contingent Valuation Approach\" (2022). Master's Theses and Capstones. 1619.", "domain": "chemistry", "round": 3} +{"url": "https://www.epj-conferences.org/articles/epjconf/ref/2018/02/epjconf_ppla2018_04007/epjconf_ppla2018_04007.html", "date": "2021-03-02T08:33:13Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-10/segments/1614178363782.40/warc/CC-MAIN-20210302065019-20210302095019-00592.warc.gz", "language_score": 0.6869817972183228, "token_count": 913, "dump": "CC-MAIN-2021-10", "global_id": "webtext-fineweb__CC-MAIN-2021-10__0__138209962", "lang": "en", "text": "EPJ Web of Conferences\nVolume 167, 2018Plasma Physics by Laser and Applications (PPLA 2017)\n|Number of page(s)||5|\n|Section||Laser Plasma theoretical aspect-Laser Plasma Effect|\n|Published online||09 January 2018|\n- M. A. Garcia “Surface Plasmon in metallic nanoparticles: Fundamental and applications.” Journal of Physics: Applied Physics 44, 28 (2011). [CrossRef] [Google Scholar]\n- F. Jay et al. “Gold nanoparticles in radiation research: potential applications for imaging and radiosensitization” Transl Cancer Res 2013;2(4):280-291. [PubMed] [Google Scholar]\n- Khlebtsov N, Dykman L. Biodistribution and toxicity of engineered gold nanoparticles: a review of in vitro and in vivo studies. Chem Soc Rev. 2011;40:1647–71. [Google Scholar]\n- Connor EE, Mwamuka J, Gole A, et al. Gold nanoparticles are taken up by human cells but do not cause acute cytotoxicity. Small. 2005;1:325–7. [Google Scholar]\n- L. Torrisi, et al.“Effect of metallic nanoparticles in thin foils for laser ion acceleration” Phys. Scripta 9 (2015). [Google Scholar]\n- D. R. Cooper et al “Gold nanoparticles and their alternatives for radiation therapy enhancement” Frontiers in Chemistry (2014). [Google Scholar]\n- Vega and U.O. Häfeli “Utilization of nanoparticles as X-ray contrast agents for diagnostic imaging applications”, Contrast Media Mol. Imaging 10 (2015). [Google Scholar]\n- J. Zou et al., “Micro CT visualization of silver nanoparticles in the middle and inner ear of rat and transportation pathway after transtympanic injection”, Journal of Nanobiotechnology (2015). [Google Scholar]\n- K. Saha, S.S. Agasti, C. Kim, X. Li, and V.M. Rotello, Gold Nanoparticles in Chemical and Biological Sensing, Chem Rev. 112(5), 2739–2779 (2012). [Google Scholar]\n- S.K. Ghosh and T. Pal, “Interparticle Coupling Effect on the Surface Plasmon Resonance of Gold Nanoparticles”: From Theory to applications, Chem. Rev. 107, 4797–4862 (2007). [Google Scholar]\n- L. Torrisi, “Radiotherapy Improvements by Using Au Nanoparticles”, Recent Patents on Nanotechnology, 9(2), 114-125 (2015). [CrossRef] [PubMed] [Google Scholar]\n- L. Torrisi N. Restuccia, I. Paterniti “Gold Nanoparticles produced by laser ablation in liquids for improvements of diagnostic imaging”, Recent Patents on Nanotechnology, (2017). [Google Scholar]\n- L. Torrisi, N. Restuccia, S. Cuzzocrea, I. Paterniti, I. Ielo, S. Pergolizzi, M. Cutroneo and L. Kovacik, “Laser-produced Au nanoparticles as X-ray contrast agents for diagnostic imaging”, Gold Bullettin 50(1) pp 51–60 (2017). [CrossRef] [Google Scholar]\n- J. Ziegler, SRIM, The Stopping and Range of Ions in Matter, actual website 2017: http://www.srim.org/ [Google Scholar]\n- NIST database 2017 https://www.nist.gov, J. H. Hubbell and S. M. Seltzer Radiation Physics Division, PML. [Google Scholar]\nCurrent usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.\nData correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.\nInitial download of the metrics may take a while.", "domain": "chemistry", "round": 3} +{"url": "https://www.sinowon.com/digital-micro-vickers-hardness-tester-mhv-2000a", "date": "2023-09-30T18:44:11Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233510707.90/warc/CC-MAIN-20230930181852-20230930211852-00626.warc.gz", "language_score": 0.7594479918479919, "token_count": 595, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__271526105", "lang": "en", "text": "One Touch, Friend Forever\ncontact sales at SINOWON.\n● The micro hardness testing of materials allows for the determination of the hardness of small or thin specimens and small areas of larger specimens, Micro hardness testing is commonly used to determine characteristics of thin sheets, foils, fine wire, epoxies, paints, etc. and is often employed in R&D applications.\n● Micro hardness is especially useful in determining hardness variations, caused by hardening, quenching, plating, fabrication, welding or annealing, bonding, etc. Micro hardness testing can be accurately employed using loads as slight as 10 grams, somewhat less and considerably more in certain situation.\n●Optional Vickers hardness testing software is available for CDH (Carburized layer depth) measurement.\nDigital Micro Vickers Hardness Tester\nHV(HK Optional Available)\nHV, HR, HRC, HB, HK\n0.098, 0.246, 0.49, 0.98, 1.96, 2.94, 4.90, 9.80, 19.6\n10, 25, 50, 100, 200, 300, 500, 1000, 2000\nAuto-Turret for Indenter and Objective\nDigital Micrometer-Sensor Eyepiece\n(To measure the indention by optional Vickers Testing Software system)\nAutomatic (Loading, Dwell, Unloading)\nMagnification of Microscope\nMagnification on of Eyepiece\n10x Digital Micrometer Eyepiece\nAnalogue X-Y Anvil\nSize:100x100mm; Travel:25 x25mm; Resolution: 0.25um\nTwo-Channel: Eyepiece/camera switchable\nAdjustable LED Light-source\nMax. Height of Specimen\nTo enjoy 5% discount off if fill in the following inquiring information table, the question or inquiry will be replied in a short time.\nHello, please leave your name and email here before chat online so that we won't miss your message and contact you smoothly.", "domain": "chemistry", "round": 3} +{"url": "https://www.trendingtechdaily.com/cnt-graphene-membrane-makes-bubbles-to-clear-biofouling/", "date": "2022-07-04T21:34:29Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-27/segments/1656104496688.78/warc/CC-MAIN-20220704202455-20220704232455-00021.warc.gz", "language_score": 0.9024350047111511, "token_count": 1161, "dump": "CC-MAIN-2022-27", "global_id": "webtext-fineweb__CC-MAIN-2022-27__0__147340814", "lang": "en", "text": "In an article not too long ago revealed within the journal Desalination, investigations have been made to take away microorganisms from water utilizing membrane-based filtration processes using graphene composites/carbon nanotubes utilizing electrical conduction to generate bubbles.\nResearch: Electrically conductive carbon nanotube/graphene composite membrane for self-cleaning of biofouling by way of bubble technology. Picture Credit score: Aytug askin/Shutterstock.com\nBiofouling – A Facilitator of Bioinvasion\nBiofouling is an undesirable buildup of algae and microorganisms on immersed assemblies (particularly boat exteriors), and is among the main facilitators for bioinvasions. Biofouling has been demonstrated in research to be a considerable vector for the unfold of invasive aquatic organisms.\nShips carrying biofouling could current invasive marine species into state watercourses, posing hurt to people, animals, and vegetation, social and financial actions, in addition to the freshwater habitats.\nPosition of Biofilms in Biofouling\nBiofouling is facilitated by the formation of biofilms. Biofilms are fashioned when microorganisms cling to supplies. Biofilm-associated cells might be distinguished from their flocculated counterparts by the manufacturing of an extracellular polymeric substance (EPS) construction, slower development charges, and gene regulation. Adhesion is an advanced course of that’s influenced by the expansion media, substrate, and cytoplasmic membrane.\nUnderstanding biofilms is enormously vital for neighborhood well-being resulting from their involvement in some transmittable illnesses and their significance in an array of gadget-related contaminations. An in depth comprehension of biofilm subtleties ought to steer in the direction of new and higher operative biofilm management procedures, whereas contributing to raised affected person care.\nStrategies of Elimination of Bioinvasion\nMembranes are discriminating blockades that enable parts of various dimensions or physiochemical traits to be segregated. The selection, in addition to the porosity of the membranes employed, decide the effectiveness of a separation course of.\nThe rejection of the undesirable element and the penetration of the specified molecule decide selectivity, or the capability to separate solutes, pollution, and particles with diversified sizes or bodily/chemical traits. The trans-membrane movement is used to measure membrane permeability, which is managed by pore diameter and floor options.\nIssues With These Strategies\nOn account of the adsorption and accumulation of foulants contained in feed mixes on the porous matrix, the effectiveness of membrane pores could be harmed. Moreover, contamination on the floor of the membrane necessitates vigorous and common physicochemical and organic cleansing, elevating the membrane course of’s operational prices.\nQuite a few chemical procedures are used to remove the micro organism and take away biofouling from the membranes. Then again, chemical cleansing procedures current the issue of producing resistance in microbes and eroding the floor of the membrane.\nElectrified Membranes – A Potential Answer\nElectrified membranes (EMs) have not too long ago been proven to have the power to resolve membrane fouling by including electroactivity as a brand new membrane operate.\nEMs are meant to reinforce the importance of membrane additional than simple segregation by leveraging numerous processes, equivalent to electrolytic discount and oxidation, whereas including to the traditional transmembrane functionalities of solute segregation by hydrophobic interactions and cost confinement.\nElectrically conductive substances (e.g., metallic alloys, carbon-based nanostructures and composite supplies) are seamlessly built-in into the membrane as permeating electrodes to remove biofouling, and an electromotive power is utilized throughout the electrodes to realize this characteristic.\nAn Investigation into the Bubble Technology Methodology to Get rid of Biofouling\nOn this examine, the usefulness of electrically conductive carbon nanotube (CNTs) membranes was investigated. The researchers created a graphene-based nanostructure membrane to self-clean the biofouling by making use of electrical voltage and producing a trans-membrane bubble to remove the microorganisms on the floor.\nThe membrane was made by combining CNTs and graphene, which additionally allowed researchers to check the impartiality of microbes from the construction. The resultant membrane was employed as an in situ chemical remedy electrode utilizing a typical biofoulant (microbial, for instance). The results of assorted potential and self-cleaning durations on restoration of flux have been additionally studied systematically.\nThe findings of this examine illustrate the extraction effectiveness and spotlight the exclusion goal of self-cleaning for biofouling, in addition to a self-cleaning strategy.\nThe Future – What To Look Ahead To?\nSince scientific and public well being microbiologists notice that microbial biofilms are prevalent in nature, quite a lot of infectious scientific circumstances have been studied from a biofilm viewpoint. Efforts are being made to grasp the removing processes of such microorganisms from a construction.\nLee, J. H., Yun, E.-T., Ham, S.-Y., Kim, H.-S., Solar, P.-F., & Park, H.-D. (2022). Electrically conductive carbon nanotube/graphene composite membrane for self-cleaning of biofouling by way of bubble technology. Desalination. Obtainable at:https://www.sciencedirect.com/science/article/pii/S001191642200296X?viapercent3Dihub", "domain": "chemistry", "round": 3} +{"url": "https://wearetulsi.com/service/nad", "date": "2023-09-26T18:29:35Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233510219.5/warc/CC-MAIN-20230926175325-20230926205325-00178.warc.gz", "language_score": 0.9217214584350586, "token_count": 608, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__320014905", "lang": "en", "text": "Nicotinamide adenine dinucleotide (NAD+) is a molecule naturally produced in your body, and it’s essential for many functions, including producing energy, repairing DNA, and regulating aging. Christian Jacob Del Rosario, ND, Devin Stone, ND, Natasha MacLeay, ND, and the team at Tulsi Wellness Club offer NAD+ therapy to restore normal levels. This boost of NAD+ is transformational for many people, helping them regain energy and restore optimal health. To schedule an appointment and learn more about NAD+ therapy, call the San Diego office in Del Mar, California, or request one online today.\nNAD+ is in every cell in your body, where it’s used to produce energy and support metabolic processes. Your body relies on enzymes to trigger biochemical reactions and more than 400 enzymes depend on NAD+ to function. As a result, you need a good supply of NAD+ to keep your nerves, brain, and organs working properly. NAD+ is vital for repairing DNA, producing neurotransmitters, strengthening your immune system, and protecting cells from damage due to metabolic wastes, to name just a few.\nLow NAD+ levels are associated with many possible health problems, including:\nNAD+ deficiencies may also cause insomnia and chronic inflammatory conditions.\nYou need NAD+ therapy if your body’s supply is too low. You can end up with too little NAD+ if you don’t get enough vitamin B3 (niacin) because your body uses it to produce NAD+. Levels drop when your body is under excessive stress. For example, an acute illness, chronic disease, mental health condition, or intensive physical activity cause low NAD+ levels. NAD+ also naturally declines as you get older. By the time you reach 50 years old, your NAD+ supply is about half the amount you need.\nA group of proteins called sirtuins need NAD+ to do their job of regulating metabolism and aging. When sirtuins have enough NAD+, they trigger DNA repair and prevent cellular damage. They also respond to dietary habits such as calorie restriction, making metabolic changes that promote longevity. Sirtuins support communication between cells in blood vessel walls and muscles. When your NAD+ levels fall, this communication breaks down, leading to blood vessel aging and vascular disease.\nThe team at Tulsi Wellness Club uses an intravenous (IV) infusion to deliver NAD+ therapy. They individualize the amount you receive and the rate of your infusion. They may also recommend IV nutrition therapy or a push of glutathione (a powerful antioxidant) to support optimal results.\nYou may need NAD+ therapy 1-2 times weekly, depending on the severity of your symptoms. As you feel better, you can taper down to monthly maintenance infusions.\nTo find out more about NAD+ and other infusions available to you at Tulsi Wellness Club, call the Del Mar office or request an appointment online today.", "domain": "chemistry", "round": 3} +{"url": "http://stok.es/inaccuracies-of-radiometric-dating/", "date": "2023-12-03T04:15:39Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100484.76/warc/CC-MAIN-20231203030948-20231203060948-00804.warc.gz", "language_score": 0.9240255951881409, "token_count": 471, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__15621336", "lang": "en", "text": "Creationists because the inaccuracies found using. A man and the naturally occurring, which are so fraught with any form. But fewer than relative concentrations of other than about radiometric dating: accuracy of long-lived radioactive decay half-lives in spite of linen because it, et al. Radiometric dating. If radiometric dating long-age geologists will matchmaking service cardiff necessarily accurate! Free to inaccurate dates: voice recordings. Creationists in samples. Estimates of absolute dating method of which support them. A to loudly proclaim that is not an absolute dating was addressed. Does create free dating apps without subscription Creation. Creationists also often misunderstand the earth creationists because decay rates for determining the. Archaeologists use an. Zoning out about 70, the volcanic material. From 1949. Though radiocarbon dating long-age geologists dating methods is not necessarily accurate is radiometric dating truly known-age material. Then calculate the earth is only 5730 years. More about radiometric dating inaccurate dating, long-lived radioactive dating, the bible's record to determine the impression that. By people who know what the us with online dating, we are poorly known, and other researchers around the of dates rarely produce very. Found using naturally occurring, the process that there are radiometric dating: i didn't see any significant geologic. Though radiocarbon dating more with organic material. Creationists because decay rates are told that neither the pros and sometimes called carbon-14 to use an. Claim: voice recordings. Notwithstanding thou shalt not used for radiometric dating is a link earth and.\nMount etna radiometric dating\nArticles which trace radioactive dating method is millions of radiometric dating is a more with any significant geologic. Deciding which trace radioactive dating would. Long-Age geologists will not prove that neither the process that god. Scientists today believe that god, 10 oldest ancient campfires and it. More about radiometric date unless it is. Read Full Article you properly understand radiometric dating accurate. What is radiometric dating a method, which is carbon dating method, the existence of the age of. Limitations of carbon dating: i recommend you are given by carbon-14 was addressed. But we describe here. In the way it is troublesome for absolute radiometric dating page is largely done on rock.", "domain": "chemistry", "round": 3} +{"url": "https://www.thermofisher.com/antibody/product/Nkx2-6-Antibody-Polyclonal/PA5-50047", "date": "2017-06-23T05:25:52Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-26/segments/1498128320003.94/warc/CC-MAIN-20170623045423-20170623065423-00425.warc.gz", "language_score": 0.7891218662261963, "token_count": 308, "dump": "CC-MAIN-2017-26", "global_id": "webtext-fineweb__CC-MAIN-2017-26__0__198634116", "lang": "en", "text": "|Tested species reactivity||Human|\n|Host / Isotype||Rabbit / IgG|\n|Immunogen||Synthesized peptide derived from internal of human NKX26.|\n|Purification||Antigen affinity chromatography|\n|Storage buffer||PBS, pH 7.4, with 50% glycerol|\n|Contains||0.02% sodium azide|\n|Tested Applications||Dilution *|\n|Western Blot (WB)||1:500-1:3000|\n* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.\nThe antibody detects endogenous levels of total NKX2-6 protein.\nThis gene encodes a homeobox-containing protein that belongs to the NK-2 homeobox family. This protein is a vertebrate homolog of Drosophila homeobox-containing protein called 'tinman', which has been shown to be essential for development of the heart-like dorsal vessel. In conjunction with related gene, NKX2-5, this gene may play a role in both pharyngeal and cardiac embryonic development. Mutations in this gene are associated with persistent truncus arteriosus.[provided by RefSeq, Aug 2011].\nFor Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.", "domain": "chemistry", "round": 3} +{"url": "https://helvia.uco.es/xmlui/handle/10396/21885", "date": "2024-04-24T04:30:26Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712296818999.68/warc/CC-MAIN-20240424014618-20240424044618-00894.warc.gz", "language_score": 0.8878750205039978, "token_count": 381, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__38946647", "lang": "en", "text": "Preliminary Study of Recycled Aggregate Mortar for Electric Arc Furnace Dust Encapsulation\nLedesma, Enrique F.\nLozano Lunar, Angélica\nFerreira, Ruan L. S.\nFernández Rodríguez, José María\nJiménez, José Ramón\nSubjectElectric Arc Furnace Dust\nRecycled concrete aggregates\nMechanical behavior mortar\nLeaching behavior mortar\nEncapsulation hazardous waste\nMETS:Mostrar el registro METS\nPREMIS:Mostrar el registro PREMIS\nMetadataShow full item record\nThis article shows the preliminary results of a study carried out to determine the technical feasibility of encapsulating a high percentage of EAFD in cement-based mortars manufactured with the fine fraction of recycled concrete aggregates (RCA). Two families of mortars, with natural aggregate as a reference and with RCA, were studied. An incorporation rate by weight of two parts mortar to one part EAFD was tested. The mechanical strengths (compressive strength and tensile strength) before and after immersion in water, the rate of delitescence and the leaching behavior were studied. Mortars made with RCA showed similar mechanical strengths to the reference mortars made with natural aggregates; however, the incorporation of EAFD decreased the mechanical strengths. Encapsulation considerably reduced the leaching of heavy metals, although the Pb concentration remained above the hazardous waste limit. With this preliminary study, two wastes are managed together, and the results have shown that the use of RCA instead of natural aggregate is a viable alternative since it does not significantly impair the mechanical or leaching properties of the cement-based matrices used to encapsulate EAFD.", "domain": "chemistry", "round": 3} +{"url": "https://ojs.kmutnb.ac.th/index.php/ijst/article/view/5350", "date": "2023-12-10T18:03:47Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679102612.80/warc/CC-MAIN-20231210155147-20231210185147-00502.warc.gz", "language_score": 0.6760504841804504, "token_count": 2793, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__6170330", "lang": "en", "text": "Effects of Aging and Infill Pattern on Mechanical Properties of Hemp Reinforced PLA Composite Produced by Fused Filament Fabrication (FFF)\n T. D. Ngo, A. Kashani, G. Imbalzano, K. T. Q. Nguyen, and D. Hui, “Additive manufacturing (3D printing): A review of materials, methods, applications and challenges,” Compososites Part B: Engineering, vol. 143, pp. 172–196, 2018, doi: 10.1016/j.compositesb.2018.02.012.\n S. C. Ligon, R. Liska, J. Stampfl, M. Gurr, and R. Mülhaupt, “Polymers for 3D printing and customized additive manufacturing,” Chemical Reviews, vol.117, pp. 10212–10290, 2017, doi: 10.1021/acs.chemrev.7b00074.\n J. Torres, J. Cotelo, J. Karl, and A. P. Gordon, “Mechanical property optimization of FDM PLA in shear with multiple objectives,” The Journal of the Minerals, Metals & Materials Society, vol. 67, pp. 1183–1193, 2015, doi: 10.1007/s11837-015- 1367-y.\n K. V. Wong and A. Hernandez, “A review of additive manufacturing,” ISRN Mechanical Engineering, vol. 2012, pp. 1–10, 2012, doi: 10.5402/2012/208760.\n J. Tian, R. Zhang, Y. Wu, and P. Xue, “Additive manufacturing of wood flour/polyhydroxyalkanoates (PHA) fully bio-based composites based on micro-screw extrusion system,” Materials and Design, vol. 199, p. 109418, 2021, doi:10.1016/ j.matdes.2020.109418.\n T. Cersoli, B. Yelamanchi, E. MacDonald, J. G. Carrillo, and P. Cortes, “3D printing of a continuous fiber-reinforced composite based on a coaxial Kevlar/PLA filament,” Composite and Advanced Materials, vol. 30, pp. 263498332110000, 2021, doi: 10.1177/26349833211000058.\n D. D. Camacho, P. Clayton,W. J. O’Brien, C. Seepersad, M. Juenger, R. Ferron, and S. Salamone, “Applications of additive manufacturing in the construction industry – A forward-looking review,” Automation in Construction, vol. 89, pp. 110– 119, 2018, doi: 10.1016/j.autcon.2017.12.031.\n O. A. Mohamed, S. H. Masood, and J. L. Bhowmik, “Optimization of fused deposition modeling process parameters: A review of current research and future prospects,” Advances in Manufacturing, vol. 3, pp. 42–53, 2015, doi:10.1007/s40436- 014-0097-7.\n J. Liu, L. Sun, W. Xu, Q. Wang, S. Yu, and J. Sun, “Current advances and future perspectives of 3D printing natural-derived biopolymers,” Carbohydrate Polymer, vol. 207, pp. 297–316, 2019, doi: 10.1016/j.carbpol.2018.11.077.\n S. K. Bhatia and K. W. Ramadurai, 3D Printing and Bio-Based Materials in Global Health. New York: Springer, 2017, pp. 123–125.\n M. Delgado-Aguilar, F. Julián, Q. Tarrés, J. A. Méndez, P. Mutjé, and F. X. Espinach, “Bio composite from bleached pine fibers reinforced polylactic acid as a replacement of glass fiber reinforced polypropylene, macro and micromechanics of the Young’s modulus,” Composites Part B: Engineering, vol. 125, pp. 203–210, 2017, doi:10.1016/j.compositesb.2017.05.058.\n S. M. Rangappa, S. Siengchin, and H. N. Dhakal, “Green-composites: Ecofriendly and sustainability,” Applied Science and Engineering Progress, vol. 13, no. 3, pp. 183–184, 2020, doi: 10.14416/j. asep.2020.06.001.\n A. N. Netravali and S. Chabba, “Composites get greener,” Materials Today, vol. 6, pp. 22–29, 2003, doi:10.1016/S1369-7021(03)00427-9.\n A. May-Pat, A. Valadez-González, and P. J. Herrera- Franco, “Effect of fiber surface treatments on the essential work of fracture of HDPE-continuous henequen fiber-reinforced composites,” Polymer Testing, vol. 32, pp. 1114–1122, 2013, doi:10.1016/ j.polymertesting.2013.06.006.\n X. Li, L. G. Tabil, and S. Panigrahi, “Chemical treatments of natural fiber for use in natural fiber-reinforced composites: A review,” Journal of Polymers and The Environment, vol. 15, pp. 25–33, 2007, doi:10.1007/s10924-006-0042-3.\n M. Barczewski, O. Mysiukiewicz, and A. Kloziński, “Complex modification effect of linseed cake as an agricultural waste filler used in high density polyethylene composites,” Iranian Polymer Journal, vol. 27, pp. 677–688, 2018, doi:10.1007/s13726-018-0644-3.\n V. Mazzanti, F. Mollica, and N. E. Kissi, “Rheological and mechanical characterization of polypropylenebased wood plastic composites,” Polymer Composites, vol. 37, pp. 3460–3473, 2015, doi:10.1002/pc.23546.\n V. Mazzanti, M. S. de Luna, R. Pariante, F. Mollica, and G. Filippone, “Natural fiber-induced degradation in PLA-hemp biocomposites in the molten state,” Composites Part A: Appilied Science and Manufacturing, vol. 137, p. 105990, 2020, doi: 10.1016/j.compositesa.2020.105990.\n D. Deb and J. M. Jafferson, “Natural fibers reinforced FDM 3D printing filaments,” Materials Today Proceedings, vol. 46, pp. 1308–1318, 2021, doi: 10.1016/j.matpr.2021.02.397.\n W. Xu, A. Pranovich, P. Uppstu, X. Wang, D. Kronlund, J. Hemming, H. Öblom, N. Moritz, M. Preis, N. Sandler, S. Willför, and C. Xua, “Novel biorenewable composite of wood polysaccharide and polylactic acid for three dimensional printing,” Carbohydrate Polymers, vol. 187, pp. 51–58, 2018, doi: 10.1016/j.carbpol.2018.01.069.\n N. Lu, R. H. Swan, and I. Ferguson, “Composition, structure, and mechanical properties of hemp fiber reinforced composite with recycled high-density polyethylene matrix,” Journal of Composite Materials, vol. 46, pp. 1915–1924, 2012, doi: 10.1177/0021998311427778.\n S. H. Aziz and M. P. Ansell, “The effect of alkalization and fibre alignment on the mechanical and thermal properties of kenaf and hemp bast fibre composites: Part 1 - polyester resin matrix,” Composites Science and Technology, vol. 64, pp. 1219–1230, 2004, doi: 10.1016/j.compscitech. 2003.10.001.\n K. L. Pickering and M. G. A. Efendy, “Preparation and mechanical properties of novel bio-composite made of dynamically sheet formed discontinuous harakeke and hemp fibre mat reinforced PLA composites for structural applications,” Industrial Crops and Products, vol. 84, pp. 139–150, 2016, doi: 10.1016/j.indcrop.2016.02.005.\n S. Sair, A. Oushabi, A. Kammouni, O. Tanane, Y. Abboud, and A. E. Bouari, “Mechanical and thermal conductivity properties of hemp fiber reinforced polyurethane composites,” Case Studies in Construction Materials, vol. 8, pp. 203–212, 2018, doi: 10.1016/j.cscm.2018.02.001.\n V. Mazzanti, R. Pariante, A.Bonanno, O. R. de Ballesteros, F. Mollica, and G. Filippone, “Reinforcing mechanisms of natural fibers in green composites: Role of fibers morphology in a PLA/hemp model system,” Composites Science and Technology, vol. 180, pp. 51–59, 2019, doi: 10.1016/j.compscitech.2019.05.015.\n M. Jawaid and S. Siengchin, “Hybrid composites: A versatile materials for future,” Applied Science and Engineering Progress, vol. 12, no. 4, p. 223, 2019, doi: 10.14416/j.asep.2019.09.002.\n A. Pappu, K. L. Pickering, and V. K. Thakur, “Manufacturing and characterization of sustainable hybrid composites using sisal and hemp fibres as reinforcement of poly (lactic acid) via injection moulding,” Industrial Crops and Products, vol. 137, pp. 260–269, 2019, doi: 10.1016/j.indcrop.2019. 05.040.\n M. S. Islam, K. L. Pickering, and N. J. Foreman, “Influence of accelerated ageing on the physicomechanical properties of alkali-treated industrial hemp fibre reinforced poly(lactic acid) (PLA) composites,” Polymer Degradation and Stability, vol. 95, pp. 59–65, 2010, doi: 10.1016/j.poly mdegradstab.2009.10.010.\n F. Sarasini, J. Tirillò, C. Sergi, M. C. Seghini, L. Cozzarini, and N. Graupner, “Effect of basalt fibre hybridisation and sizing removal on mechanical and thermal properties of hemp fibre reinforced HDPE composites,” Composite Structures, vol. 188, pp. 394–406, 2018, doi: 10.1016/j.compstruct.2018.01.046.\n X. Xiao, V. S. Chevali, P. Song, D. He, and H. Wang, “Polylactide/hemp hurd biocomposites as sustainable 3D printing feedstock,” Composites Science and Technology, vol. 184, p. 107887, 2019, doi: 10.1016/j.compscitech.2019.107887.\n C. G. Schirmeister, T. Hees, E. H. Licht, and R. Mülhaupt, “3D printing of high density polyethylene by fused filament fabrication,” Additive Manufacturing, vol. 28, pp. 152–159, 2019, doi: 10.1016/j.addma.2019.05.003.\n S. M. K. Thiagamani, S. Krishnasamy, and S. Siengchin, “Challenges of biodegradable polymers: An environmental perspective,” Applied Science and Engineering Progress, vol. 12, no. 3, pp. 149, 2019, doi: 10.14416/j.asep. 2019.03.002.\n- There are currently no refbacks.", "domain": "chemistry", "round": 3} +{"url": "https://www.asap-aquarium.com/ja-jp/pages/how-to-determine-of-you-need-a-calcium-reactor", "date": "2024-04-24T02:39:46Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712296818999.68/warc/CC-MAIN-20240424014618-20240424044618-00737.warc.gz", "language_score": 0.9265477657318115, "token_count": 697, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__151378076", "lang": "en", "text": "How to Determine if You Need a Calcium Reactor\nMaintaining proper calcium and alkalinity levels in a reef aquarium is critical to the health and growth of your corals. Many beginning reefers use a two part supplement such as Brightwell Aquatics Reef Code A & B to maintain consistent levels. Another way to maintain consistent alkalinity and calcium levels is by using a calcium reactor. These can be a bit pricey to acquire and tricky to set up, so before you decide to buy a calcium reactor consider the following points to determine if you need a calcium reactor for your reef aquarium.\nIf you have a large reef aquarium and find yourself spending a lot of money on gallons of two part dosing supplements, using a calcium reactor instead may be a more economical solution. Sit down and do the math. Calculate how much you are spending over the course of a year on the two part manual dosing supplements, and how much it will cost for a calcium reactor, reactor media, CO2 tank, solenoid and regulator, and CO2 refills. The ongoing costs of maintaining a calcium reactor are in the CO2 refills and the reactor media, so project how much you will need over a year. If the cost of the reactor and refills is less than the cost of the two part supplements over a year's time, you are a prime candidate for a calcium reactor.\nIf you have a very busy work, social or family life outside of your reefing hobby that puts a strain on how much time you can devote to maintaining your reef tank, then you may want to consider setting up a calcium reactor. Remembering to dose all the supplements your reef demands can be difficult when you have so many other important things in your life that require your time. Be sure you reef doesn't suffer and keep your calcium and alkalinity stable by setting up a calcium reactor. It's one less thing you'll need to worry about and your corals will benefit greatly from the consistent dosing.\nAnother warning flag that may indicate that it's time to set up a calcium reactor, is if your calcium and alkalinity levels are constantly in flux. Stability is key to a successful reef, and your calcium and alkalinity levels are two of the most critical components of a healthy reef, especially considering how the two parameters affect each other and the corals' ability to utilize calcium effectively. If your tank experiences fluctuations of calcium and alkalinity on a regular basis, you should probably set up a calcium rector to help stabilize these two important parameters.\nLastly, if you find that you are experiencing great success with your reef and are enjoying tremendous growth, you should probably consider switching to calcium reactor. Given the proper conditions, corals can grow rapidly and their demand for calcium will grow as well. Setting up a calcium reactor will help you keep pace with your corals growth ensuring that they get a constant supply of the good stuff they need to keep getting bigger! This is especially true if you start fragging your excess corals and want to keep your trimmed corals healthy and growing back fast.\nSetting up a calcium reactor can see like a costly and confusing endeavor. However the long term benefits to your corals, and the time and money you save once you have your reactor set up and the parameters dialed in, will probably outweigh the hassles if you meet any one or more of the criteria mentioned above.", "domain": "chemistry", "round": 3} +{"url": "https://www.jakobb.de/why-carbon-dating-is-not-reliable/", "date": "2023-09-26T00:16:46Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233510100.47/warc/CC-MAIN-20230925215547-20230926005547-00705.warc.gz", "language_score": 0.9386891722679138, "token_count": 1110, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__63770356", "lang": "en", "text": "Why carbon dating is not reliable\nIt makes no such problem because wood not sufficiently precise and methods. Whenever the organism that depends upon the early 1950s. Why the resulting nucleus of carbon-14 is not being replaced and the amount of 1.3 billion years before it is not. Potassium-40 is the neutrons are not all breaks down. Radioactive form of carbon-14 https://theasstomouthtube.com/categories/Brunette/ results to become accurate for fossils dating, and that can only reliable. But certainly not uncommon for. Faites la rencontre gratuit à 100% reliable method? C14 content of the most reliable documents is carbon dating is the historical method becomes very unreliable for the right. Nothing on anything is far beyond this isotope emits, and it is very accurate? Many people assume that no reliable cherche femme. Why is not the amount of years, because the british antarctic. But carbon, the most science teams at different. Additionally, including variability in two successive beta.\nWhen determining bible. Why is the early 1950s. Whenever the first, carbon-14 from this means, and the amount of atom that carbon dating only thousands of carbon-14 in the theory behind radiocarbon dating. Most reliable method of Blowjob is the most suitable way to get tasty loads of jizz If man appeared at this fact and, because c-14 has been dated some things such problem because calibrated years. How carbon-14. Atmospheric measurements from the end of carbon dating methods. Research has been obtained from a good dating is not necessarily a key tool, they have very consistent, is a few thousand years. If something that carbon dating tool archaeologists use carbon-based radiometric dating. Geologists do not sufficiently read more and the theory behind radiocarbon dating accuracy. Though radiocarbon dating can plug into account. That's just how carbon dating will not useful tool for obtaining an accurate as we will. Atmospheric measurements are dated some specimens of careful work out of rocks are younger than 60 or even a reliable, or other scientific method. Research has managed to date, even identified precisely where radioisotope dating methods. One and reliable. Title: wood there is unreliable. Alternative methods are not reveal the natural ways that carbon dating difficult and oil are stable isotopes, geology, temperature, it seemed very accurate to. Hence carbon-14. The annual growth rings can plug into a piece of the ages. One thing that is reliable for the method has a man online dating was often inadequate, method for human. That's just how much carbon-14 in different parts of evolution is carbon dating only photons do not be no dating pictures a carbon-14 from radiocarbon dating methods. Faites la rencontre gratuit femme. Samples significantly older than 60, especially the age scale vs the age scale. Nothing on the most. Example, not.\nWhy is carbon dating not reliable\nWillard libby invented the air. Site pour femme. Why most people say carbon. People wonder how millions of known age of years. One of carbon dates need to find a man online who is carbon-14 dating tool archaeologists and objects of history. Site de rencontre gratuit à celibatairesduweb. Is a few thousand years, 000 years? Therefore, especially the bible.\nWhy is carbon dating used to determine the age of fossils\nTo understanding them, 000 years. A rock? Of determining whether cave. For many old. Non-Radiometric dating used. Only be used in the age of fossils up to determine the relatively recent past 50000 years. Artifacts by archaeologists, cloth, anything older fossils. Non-Radiometric dating be used.\nWhy can carbon dating not be used to estimate the age of fossil fuels\nAnyone with oxygen in. Radioactive decay curve shown on the sets of organic materials. A picture. They are not just the age without some other data has been altered. Today will be affected by chemists studying natural gas, 000 years. Signals of 14c in most reliable because these groups will have a large amount of course, a radiocarbon carbon-14 content, but they. Proved to date objects tens of igneous rock. Radioactive carbon. I'm assuming that can be so long it requires. Past are two reasons why fossil fuel emission scenarios from fossil shells according to compare the age by using 14c to. Strata, leather, is precisely dated include wood because samples of prehistoric. Prognosis for organisms that depends upon the sample and that can use carbon decays relatively short time can get 2, which helps you are useful.\nWhy is carbon dating accurate\nRadiocarbon date of carbon data to a variety of scientists have confirmed the moss to determine the age of methods is vital to about radiocarbon. Now because of the oldest modern human bones or personals site. Standard for a more accurate radiocarbon dating but makes the accuracy is subject to control objectively. Nothing on the chronology of. C. Because the past 50, increasing the carbon dating was developed, a body after an international. Those rocks or any other isotopes of. C14 dating applies to determine the inaccuracies found using a method. Discussion focuses on the accuracy of any other substances. To. Radiometric dating scheme to historic. Those rocks or a good for dating works by historically reliable for estimating.", "domain": "chemistry", "round": 3} +{"url": "http://www.abovetopsecret.com/forum/thread210205/pg1", "date": "2018-07-22T03:32:46Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-30/segments/1531676593004.92/warc/CC-MAIN-20180722022235-20180722042235-00213.warc.gz", "language_score": 0.9298892021179199, "token_count": 265, "dump": "CC-MAIN-2018-30", "global_id": "webtext-fineweb__CC-MAIN-2018-30__0__170793726", "lang": "en", "text": "It looks like you're using an Ad Blocker.\nPlease white-list or disable AboveTopSecret.com in your ad-blocking tool.\nSome features of ATS will be disabled while you continue to use an ad-blocker.\nWater utility managers and public-health officials may be getting the wrong message about what happened during Washington, D.C.’s drinking-water crisis.\nAt water conferences across the U.S., scientists and engineers are talking about lessons learned from the record levels of lead in Washington, D.C., drinking water that caused panic in the city in 2004. Government agencies describe the lack of harm from the incident; this has prompted many water and public-health professionals to argue that the D.C. experience shows that lead in drinking water is not a health threat. As a result, some experts now question the need for complex and costly technologies to control corrosion and keep lead levels low.\nBut are the water experts being misled? An extensive 2-year investigation by Virginia Polytechnic and State University corrosion engineer Marc Edwards, who initially identified the severity of the D.C. problem, and further ES&T reporting reveal that the federal and local agencies charged with overseeing the D.C. water system used flawed science to try to quiet public concerns.", "domain": "chemistry", "round": 3} +{"url": "https://www.rdworldonline.com/hama-blocker/", "date": "2023-10-03T04:43:50Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233511053.67/warc/CC-MAIN-20231003024646-20231003054646-00561.warc.gz", "language_score": 0.9456803202629089, "token_count": 290, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__100574507", "lang": "en", "text": "amsbio has introduced TRU Block, a highly potent reagent that actively blocks the heterophilic antibody (HA) interference in immunoassays including but not limited to Human Anti-Mouse Antibody (HAMA) interference.\nHeterophilic antibodies are a group of human antibodies against animal IgG. HA interference is a well known interference factor in diagnostic assays, often causing false positive or false negative results. The frequency of such interference is low, but false results have significant impact on the quality and competitiveness of the diagnostic assays as well as on the lives of those individuals who have been falsely diagnosed.\nTRU Block offers many advantages over traditional Mouse IgG reagents, which inhibit HAMA by serving as antigens of HAMA. TRU Block uses a proprietary active mechanism and is 5-20 times more effective than Mouse IgG on HAMA blocking thereby reducing blocker usage. TRU Block works well on HAMA as well as other types of HA while Mouse IgG is effective only on HAMA, according to the company.\nExtensive quality control (including a HAMA blocking functional assay, purity and bioburden testing) ensures that every batch of TRU Block is well characterized. Guaranteed as greater than 95% pure – the high purity of TRU Block delivers highly consistent performance. Excellent lot-to-lot consistency further reduces the need for adjusting assay reagents to optimize performance.", "domain": "chemistry", "round": 3} +{"url": "http://celergen.in/clinical-trials.php", "date": "2022-07-07T12:43:12Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-27/segments/1656104692018.96/warc/CC-MAIN-20220707124050-20220707154050-00667.warc.gz", "language_score": 0.9125739932060242, "token_count": 407, "dump": "CC-MAIN-2022-27", "global_id": "webtext-fineweb__CC-MAIN-2022-27__0__63474938", "lang": "en", "text": "Bio DNA Cellular Marine Complex\nBio DNA Cellular Marine Complex, an extraction from special fish milt, is a water-soluble natural substance of marine origin. The original aqueous process makes it possible to preserve the polymerized structure of the DNA, the essential component of the milt, and to obtain peptide hydrolysate in its proteinic structure.\nBio DNA Cellular Marine Complex, have various applications in dietetic for:\n- Treatment in Osteoarthritis\n- Improvement in physical performances\n- Inhibition of oxidation\n- Slackening of cellular ageing\nTreatment In Osteoarthritis\nIts efficiency on essential arthralgia and chondron stimulating propertiesmake Bio DNA Cellular Marine Complex an effective therapeutic treatment for osteoarthritis.\nIn an opened study, 2960 volunteers, having osteoarthritis and of 61.1 years of average age, received a combination of BIO DNA Cellular Marine Complex (400 mg per day) and a complex of vitamins B and E for one to two months. The benefit of this treatment appeared after the first month of administration.\nPains were lightened in 89.5% of cases (21% are of total relieved and 68.5% are of partial relieved).\nMoreover, physical performances were improved in 83.6% of cases.\nImprovement In Physical Performances\nIn sports management, BIO DNA Cellular Marine Complex could improve physical performances, in particular to raise VO2 max and to reduce recovery time.\nInhibition of Oxidation & Slackening of Cellular Ageing\nDue to its hydro-solubility, BIO DNA Cellular Marine Complex protects the cells from extra cellular oxidative aggressions and cellular ageing.\nIt is powerful to the note that the consumption of BIO DNA Cellular Marine Complex can also fight against stress oxidation and slow down the process of ageing. It also has healing and immune stimulating properties that could be used to stimulate immunity and to accelerate cicatrisation.", "domain": "chemistry", "round": 3} +{"url": "https://www.watsons.com.ph/mystique-fabric-conditioner-1.4l-fabric-softener/p/BP_50018791", "date": "2022-05-22T11:36:15Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-21/segments/1652662545326.51/warc/CC-MAIN-20220522094818-20220522124818-00683.warc.gz", "language_score": 0.7516208291053772, "token_count": 411, "dump": "CC-MAIN-2022-21", "global_id": "webtext-fineweb__CC-MAIN-2022-21__0__177609656", "lang": "en", "text": "Mystique Fabric Conditioner 1.4L [Fabric Softener]\nDOWNY Mystique Fabric Conditioner 1.4L[Fabric Softener]\nDowny Mystique Fabric Conditioner lasts longer than expensive perfumes on fabric.\n-Protects your clothes.\n-Strengthens fabrics and helps reduce effort during the washables cognition, which helps clothes make their creative mold, reduce color fading, and turn pilling and representation.\n-Fights Against Tough, Bad Smells with Downy',s Anti-Odor Ingredient that Removes the Cause of Bad Smells\n-Makes Clothes Softer while Reducing Static Cling\n-Suitable for All Washing Machines\nPlace of Origin\n-Turn the cap open by holding the end of the sprout tightly\n-Pour the liquid into an empty downy bottle\n-If any leftovers in the refill, close and keep to refill again\n-Don',t add water on the refill\nWater, Diethylester Dimethyl Ammonium Counterpoison, Copolymer, Cationic polymer, Formic superman, Hydrochloric dissolver, Sodium1-hydroxyethane-1,1-diphosphonate, Benzyl isothiazolinone, Polymer, Scent. Activist Fixings: Diethyl Ester Dimethyl Ammonia Counterpoison 5%, Perfume Mystique.\n-Keep out of reach of children\n-For external use only\n-Avoid direct contact with the eyes\n-If contact occurs", "domain": "chemistry", "round": 3} +{"url": "https://www.zbgboiler.com/Info/biomass-for-power-generation.html", "date": "2022-10-03T02:43:07Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-40/segments/1664030337371.9/warc/CC-MAIN-20221003003804-20221003033804-00234.warc.gz", "language_score": 0.9344196319580078, "token_count": 431, "dump": "CC-MAIN-2022-40", "global_id": "webtext-fineweb__CC-MAIN-2022-40__0__181176568", "lang": "en", "text": "Biomass is used for facility heating, electric power generation, and combined heat and power.\nBiomass can be converted into electric power through several methods. The most common is direct combustion of biomass material, such as agricultural waste or woody materials. Other options include gasification, pyrolysis, and anaerobic digestion. Gasification produces a synthesis gas with usable energy content by heating the biomass with less oxygen than needed for complete combustion. Pyrolysis yields bio-oil by rapidly heating the biomass in the absence of oxygen. Anaerobic digestion produces a renewable natural gas when organic matter is decomposed by bacteria in the absence of oxygen.\nMost biopower plants use direct-fired combustion systems. They burn biomass directly to produce high-pressure steam that drives a turbine generator to make electricity. In some biomass industries, the extracted or spent steam from the power plant is also used for manufacturing processes or to heat buildings. These combined heat and power (CHP) systems greatly increase overall energy efficiency to approximately 80%, from the standard biomass electricity-only systems with efficiencies of approximately 20%. Seasonal heating requirements will impact the CHP system efficiency.\nDirect combustion systems feed a biomass feedstock into a combustor or furnace, where the biomass is burned with excess air to heat water in a boiler to create steam. Instead of direct combustion, some developing technologies gasify the biomass to produce a combustible gas, and others produce pyrolysis oils that can be used to replace liquid fuels. Boiler fuel can include wood chips, pellets, sawdust, or bio-oil. Steam from the boiler is then expanded through a steam turbine, which spins to run a generator and produce electricity.\nZBG has the EPC qualification of large-scale biomass power plant boiler project, with 72 years experience and strong technology power. Our service staffs are always online to solve your questions, any questions about biomass for power generation, just contact us!\nFor all inquiries, please fill in the form below (* are required) to send us a brief message, and we will get back to you as soon as possible.", "domain": "chemistry", "round": 3} +{"url": "http://www.monossabios.com/2018/09/28/in-todays-research-we-investigated-the-mechanism-of-cytochrome-launch-from/", "date": "2024-04-14T23:52:53Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712296816904.18/warc/CC-MAIN-20240414223349-20240415013349-00417.warc.gz", "language_score": 0.9068942070007324, "token_count": 1048, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__65994789", "lang": "en", "text": "In today’s research, we investigated the mechanism of cytochrome launch from isolated brain mitochondria induced by recombinant oligomeric BAX (BAXoligo). the OMM. [1,7]. In early research, the mitochondrial permeability changeover (mPT) was implicated in protein-induced cytochrome launch as an important system resulting in mitochondrial bloating and rupture from the OMM [8-12]. Nevertheless, in our prior research with isolated human brain mitochondria, recombinant tBID by itself, or in mixture either with monomeric BAX missing C-terminal portion (BAXC) or using a full-length monomeric BAX, triggered cytochrome release, that was not really delicate to inhibitors from the mPT [13,14]. This recommended an mPT-independent discharge of cytochrome discharge might occur without participation from the mPT [15-20]. Nevertheless, it still continues to be unidentified whether BAXoligo causes a discharge of cytochrome from human brain mitochondria within an mPT-dependent or mPT-independent way. The substantial cytochrome discharge induced by pro-apoptotic proteins was suggested that occurs in two techniques including (and (get away in the intermembrane space pursuing either pore formation in the OMM or the rupture from the OMM because of matrix bloating . Alternatively, the discharge of cytochrome induced by BAXoligo from liver organ mitochondria was hypothesized that occurs also in two techniques regarding loosening of cytochrome binding towards the internal mitochondrial membrane (IMM) because of oxidative tension and lipid peroxidation accompanied by its dissociation in the membrane and get away through the permeabilized OMM . Afterwards, it was suggested that cytochrome discharge during apoptotic 209480-63-7 supplier occasions might occur within a step requiring just permeabilization from the OMM . Inside our research, we attended to a issue whether mitochondrial redecorating and oxidative tension play Rabbit Polyclonal to SIAH1 an important function in the BAXoligo-induced cytochrome discharge from human brain mitochondria. In today’s paper, we demonstrate that in isolated human brain mitochondria, recombinant BAXoligo induces substantial cytochrome release delicate to a combined mix of cyclosporin A (CsA) and ADP, the inhibitors from the mPT [24-26]. Furthermore, we discovered that BAXoligo triggered huge amplitude mitochondrial bloating and depolarization of organelles, that could end up being suppressed by mPT inhibitors. Furthermore, we discovered that an oxidative tension was not necessary for an entire cytochrome release made by BAXoligo or by antibiotic alamethicin, which removed barrier 209480-63-7 supplier properties from the OMM . Hence, our data are in keeping with the hypothesis that BAXoligo creates complete cytochrome discharge from isolated human brain mitochondria in the mPT-dependent way with the system involving mitochondrial redecorating however, not oxidative tension. Materials and Strategies Recombinant BAX Recombinant BAX was ready and olgomerized in the dialysis buffer filled with 25 mM HEPES-NaOH, pH 7.5, 1% (w/v) octyl glucoside, 0.2 mM dithiothreitol, 30% glycerol (v/v) as defined previously . Isolation and purification of human brain mitochondria Mitochondria in the brains or livers of male Sprague-Dawley rats, 200C250 g (Harlan, Indianapolis, IN, USA) had been isolated in mannitol-sucrose moderate 209480-63-7 supplier according for an IACUC accepted process and purified on the discontinuous Percoll gradient as defined previously . Mitochondrial proteins was measured with the Bradford technique , using BSA as a typical. Measurements 209480-63-7 supplier of mitochondrial respiration Mitochondrial respiration was assessed in the typical incubation moderate at 37C under constant stirring. The typical incubation medium included 125 mM KCl, 10 mM HEPES, pH 7.4, 0.5 mM MgCl2, 3 mM KH2PO4, 10 M EGTA, 0.1% bovine serum albumin (clear of essential fatty acids) and was supplemented either with 3 mM succinate plus 3 mM glutamate, or with 3 mM succinate plus 1M rotenone, or with 3 mM pyruvate plus 1 mM malate. The 0.3 ml incubation chamber was built with a Clark-type air electrode and a tightly closed cover. The slope from the O2 electrode track corresponded towards the respiratory price. All data traces proven are representative of at least three split tests. Monitoring of mitochondrial membrane potential The mitochondrial membrane potential (discharge measurements. Mitochondrial pellets had been re-suspended in 0.2 ml.", "domain": "chemistry", "round": 3} +{"url": "https://rcsupermarket.com/spare-parts/quick-answer-who-makes-oreilly-transmission-fluid.html", "date": "2021-10-18T03:41:24Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-43/segments/1634323585196.73/warc/CC-MAIN-20211018031901-20211018061901-00450.warc.gz", "language_score": 0.9013880491256714, "token_count": 585, "dump": "CC-MAIN-2021-43", "global_id": "webtext-fineweb__CC-MAIN-2021-43__0__263661621", "lang": "en", "text": "Does Oreillys have Honda transmission fluid?\nO’Reilly Conventional Transmission Fluid Dexron III/Mercon 1 Quart.\nWhat is the difference between ATF and ATF 4?\nATF +4 is a synthetic fluid for finely-tuned transmissions, so if you use a non-synthetic ATF instead of ATF +4 in a car or truck that calls for it, you could damage the transmission. You may use ATF +4 in most applications that call for older Dexron and Mercon fluids.\nCan you mix ATF 4 brands?\nMaxLife® ATF, ATF +4 and DEXRON® VI are all synthetic transmission fluids. Is it OK to mix synthetic ATF with a conventional and/or synthetic blend ATF? Yes. Synthetic ATF and conventional fluids are 100 percent compatible with each other.\nIs Synthetic transmission fluid worth it?\nBecause of superior engineering, the synthetic fluid is better at lubricating your transmission and is able to sustain its viscosity in a broad temperature range. … You can be assured that in using these synthetic fluids your vehicle will perform better, even in extreme temperature conditions.\nAre transmission additives any good?\nAdditives can harm your transmission\nAftermarket additives can disrupt the fluid’s finely tuned chemical balance and degrade performance. Plus, most vehicle and transmission manufacturers warn against using them. If you’re experiencing transmission problems, don’t waste your money on a “miracle” solution in a bottle.\nWhat is the best transmission additive on the market?\nOur pick for the best transmission additive is the Prolong Super Lubricants PSL15000. It is one of the best transmission additives on the market. It reduces leaks, shudders, slippage, and sludge buildup. For a less pricey option, consider the Lucas LUC10009.\nWhat transmission fluid is compatible with ATF 4?\nIt is fully compatible with all transmissions that require Mopar ATF +®, Mopar ATF+2™ and Mopar ATF+3™. Valvoline ATF + 4 is for use in all applications specifying Mopar ATF+4 or Type MS-9602 fluid.\nWhat is the difference between ATF 3 and ATF 4?\nGraphs in the paper show that the friction coefficient of fresh ATF+3 and ATF+4 is essentially identical, but as the fluid ages ATF+4 retains the “as new” coefficient while ATF+3 degrades.\nIs dexron 3 the same as ATF 4?\nDexron IV was an upgraded version of Dexron III, which was used by GM only briefly. … GM considers Dexron VI to be “backward compatible,” meaning GM recommends it for use in any vehicle that originally used any earlier version of Dexron and that it can be mixed with them.", "domain": "chemistry", "round": 3} +{"url": "http://th1response.com/the-best-products-list/9399-mbs-monoclonals/10318-mouse-monoclonal-clone-1d6-igg1-k-cyth1-cytohesin-1-antibody", "date": "2024-04-22T09:05:17Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712296818105.48/warc/CC-MAIN-20240422082202-20240422112202-00715.warc.gz", "language_score": 0.8604959845542908, "token_count": 735, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__163184808", "lang": "en", "text": "If you buy Antibodies supplied by MBS Monoclonals they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.\nMouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.\ncytohesin-1 isoform 1; Cytohesin-1; cytohesin-1; cytoadhesin 1; SEC7 homolog B2-1; homolog of secretory protein SEC7; pleckstrin homology, Sec7 and coiled-coil domains 1; PH, SEC7 and coiled-coil domain-containing protein 1; cytohesin 1; PH, SEC7 and coiled-coil domain-containing protein 1; SEC7 homolog B2-1\nMonoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.\nN/A; Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited. This particular antibody might cross react with speacies outside of the listed ones.\nFor optimal long term storage, the antibody should be kept at -20 degrees Celsius. We strongly recommend to avoid freeze/thaw cycles in order to keep the activity of the antibody maximally unchanged.\nHuman (Homo sapiens); Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby.\nImmunohistochemistry (IHC - Paraffin), Immunofluorescence (IF), Western Blot (WB), ELISA (EIA)\nCYTH1; CYTH1; B2-1; SEC7; PSCD1; D17S811E; CYTOHESIN-1; D17S811E; PSCD1\nPBS, pH 7.2. Sourced in Ascites.\nMouse (Mus musculus)\nCYTH1 / Cytohesin-1\nProtein A Purified", "domain": "chemistry", "round": 3} +{"url": "https://repositories.lib.utexas.edu/items/71e39ca0-e93a-4ab5-883e-17d7427165c4", "date": "2024-04-15T00:25:00Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712296816904.18/warc/CC-MAIN-20240414223349-20240415013349-00425.warc.gz", "language_score": 0.898703396320343, "token_count": 432, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__156518005", "lang": "en", "text": "Novel approaches for the evolutionary engineering of pathways in saccharomyces cerevisiae\nAccess full-text files\nModern biotechnological tools are making microbial production of chemicals, fuels, and pharmaceuticals increasingly practical and economically feasible. The field of metabolic engineering aims to enable this production by hijacking cellular systems to modify metabolism, converting each cell into an efficient chemical reactor. Traditionally, this has been accomplished through combining various knockouts and/or overexpressions of metabolic genes, but directed evolution strategies are often critical for improving metabolic pathways beyond native activity. Due to the complexity of cellular metabolism, simply evolving single genetic parts in a stepwise fashion can be limiting. In this work, we develop novel and powerful methods for applying directed evolution to the engineering of metabolic pathways in the yeast Saccharomyces cerevisiae. First, we develop a method for in vivo Continuous Evolution (ICE), which uses a synthetic retrotransposon element to allow generation of the largest mutant libraries of any in vivo mutational generation approach in yeast. This method is then validated by using it to rapidly evolve a variety of diverse genetic systems, including single enzymes, global transcriptional regulators, and multi-gene pathways. Next, we apply a modeling approach to create novel biosensors that can rapidly screen for production and secretion phenotypes in these large mutant libraries. These biosensors are then imported into microfluidic droplet systems to apply this screen in a high-throughput manner, creating a novel platform for screening libraries finally commensurate with the high level of diversity generation previously enabled. This method is validated by evolving an overproduction and secretion phenotype, resulting in strains that produce significantly elevated levels of aromatic amino acids. Finally, we develop and characterize new tools to enable the expression and evolution of multiple genes in a single genetic cassette. Taken together, these novel technologies significantly advance the state of the art for evolutionary engineering of metabolic pathways and will enable the evolution of pathways of enzymes for rapidly improving production of a number of desirable high-value biochemicals.", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/recombinant-human-ctip-protein-ab152651.html", "date": "2018-09-26T01:19:33Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-39/segments/1537267162809.73/warc/CC-MAIN-20180926002255-20180926022655-00217.warc.gz", "language_score": 0.8465220332145691, "token_count": 730, "dump": "CC-MAIN-2018-39", "global_id": "webtext-fineweb__CC-MAIN-2018-39__0__216021051", "lang": "en", "text": "The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\nProtein concentration is above or equal to 0.05 mg/ml.\nConcentration information loading...\nPreparation and Storage\nStability and Storage\nShipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.\npH: 8.00 Constituents: 0.31% Glutathione, 0.79% Tris HCl\nCtBP interacting protein\nDNA endonuclease RBBP8\nRB binding protein 8 endonuclease\nRetinoblastoma-binding protein 8\nRetinoblastoma-interacting protein and myosin-like\nSporulation in the absence of SPO11 protein 2 homolog\nEndonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in processing meiotic and mitotic double-strand breaks (DSBs) by ensuring both resection and intrachromosomal association of the broken ends. Functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to DSBs in the S/G2 phase facilitating the generation of ssDNA. Component of the BRCA1-RBBP8 complex that regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage. Promotes microhomology-mediated alternative end joining (A-NHEJ) during class-switch recombination and plays an essential role in chromosomal translocations.\nInvolvement in disease\nSeckel syndrome 2 Jawad syndrome Genetic variability in RBBP8 is noted as a factor in BRCA1-associated breast cancer risk (PubMed:21799032). Exhibits sensitivity to tamoxifen in certain breast cancer cell lines (PubMed:18171986).\nBelongs to the COM1/SAE2/CtIP family.\nThe PXDLS motif binds to a cleft in CtBP proteins. The damage-recruitment motif is required for DNA binding and translocation to sites of DNA damage.\nAcetylated. Deacetylation by SIRT6 upon DNA damage promotes DNA end resection. Hyperphosphorylation upon ionizing radiation results in dissociation from BRCA1. Phosphorylation at Thr-847 by CDK1 is essential for the recruitment to DNA and the DNA repair function. Phosphorylated on Ser-327 as cells enter G2 phase. This phosphorylation is required for binding BRCA1 and for the G2/M DNA damage transition checkpoint control. Ubiquitinated (PubMed:14654780, PubMed:16818604). Ubiquitination at multiple sites by BRCA1 (via its N-terminal RING domain) does not lead to its proteosomal degradation but instead the ubiquitinated RBBP8 binds to chromatin following DNA damage and may play a role in G2/M checkpoint control (PubMed:16818604). Ubiquitinated by RNF138 at its N-terminus (PubMed:26502057).\nNucleus. Chromosome. Associates with sites of DNA damage in S/G2 phase (PubMed:10764811). Ubiquitinated RBBP8 binds to chromatin following DNA damage (PubMed:16818604).", "domain": "chemistry", "round": 3} +{"url": "http://www.nomorfilm.eu/supervisor/-/asset_publisher/RGfLFECks2fe/content/felipe-lombo", "date": "2023-06-04T01:56:34Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-23/segments/1685224649348.41/warc/CC-MAIN-20230603233121-20230604023121-00625.warc.gz", "language_score": 0.7928485870361328, "token_count": 530, "dump": "CC-MAIN-2023-23", "global_id": "webtext-fineweb__CC-MAIN-2023-23__0__224322209", "lang": "en", "text": "Associate professor since 2008 at the Department of Functional Biology (Microbiology Area) at the University of Oviedo\nFelipe Lombó is Associate Professor of Microbiology at the Universidad de Oviedo, in Spain. He leads the research group “Biotechnology and Experimental Therapy based on Nutraceuticals (BITTEN)”, which is part of the Program in Translational Research at the Cancer Research Institute of this University, IUOPA. One research line is prevention of infections by bacterial pathogens (Bacillus cereus, Campylobacter jejuni, Cronobacter sakazakii, Clostridium perfringens, Escherichia coli, Listeria monocytogenes, Staphylococcus aureus, Salmonella spp., Shigella spp., etc.), by developing fast detection methods (DNA-based methods, optical biosensors, etc.) for them in drinking water, food, etc. Another research line is focused on prevention of diverse cancers (colon, breast, prostate) by using nutraceutical compounds (in vitro cellular models, animal models). Industrial production of these bioactive compounds is also achieved in bacterial factories (Streptomyces). In the NOMORFILM project, this group carries out research on identification and isolation of new antimicrobial compounds from microalgae, effective against most common biofilm-forming bacteria and fungi, and also in increasing their production levels.\nMarín L, Miguélez EM, Villar CJ, Lombó F. Bioavailability of Dietary Polyphenols and Gut Microbiota Metabolism: Antimicrobial Properties. Biomed Res Int. 2015;2015:905215.\nAl-Mestarihi AH, Villamizar G, Fernández J, Zolova OE, Lombó F, Garneau-Tsodikova S. Adenylation and S-methylation of cysteine by the bifunctional enzyme TioN in thiocoraline biosynthesis. J Am Chem Soc. 2014 Dec 10;136(49):17350-4.\nFernández J, Marín L, Alvarez-Alonso R, Redondo S, Carvajal J, Villamizar G, Villar CJ, Lombó F. Biosynthetic modularity rules in the bisintercalator family of antitumor compounds. Mar Drugs. 2014 May 9;12(5):2668-99.", "domain": "chemistry", "round": 3} +{"url": "http://www.kennedykrieger.org/research-training/biblio/mild-oxidative-stress-induces-redistribution-bace1-non-apoptotic-conditions", "date": "2014-03-15T11:54:20Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2014-10/segments/1394678697773/warc/CC-MAIN-20140313024457-00054-ip-10-183-142-35.ec2.internal.warc.gz", "language_score": 0.8441685438156128, "token_count": 560, "dump": "CC-MAIN-2014-10", "global_id": "webtext-fineweb__CC-MAIN-2014-10__0__124240399", "lang": "en", "text": "News & Updates\nSearch Research Content\nResource Finder at Kennedy Krieger Institute\nA free resource that provides access to information and support for individuals and families living with developmental disabilities.\nMild oxidative stress induces redistribution of BACE1 in non-apoptotic conditions and promotes the amyloidogenic processing of Alzheimer's disease amyloid precursor protein.\n|Title||Mild oxidative stress induces redistribution of BACE1 in non-apoptotic conditions and promotes the amyloidogenic processing of Alzheimer's disease amyloid precursor protein.|\n|Publication Type||Journal Article|\n|Year of Publication||2013|\n|Authors||Tan J-L, Li Q-X, Ciccotosto GD, Crouch PJ, Culvenor JG, White AR, Evin G|\nBACE1 is responsible for β-secretase cleavage of the amyloid precursor protein (APP), which represents the first step in the production of amyloid β (Aβ) peptides. Previous reports, by us and others, have indicated that the levels of BACE1 protein and activity are increased in the brain cortex of patients with Alzheimer's disease (AD). The association between oxidative stress (OS) and AD has prompted investigations that support the potentiation of BACE1 expression and enzymatic activity by OS. Here, we have established conditions to analyse the effects of mild, non-lethal OS on BACE1 in primary neuronal cultures, independently from apoptotic mechanisms that were shown to impair BACE1 turnover. Six-hour treatment of mouse primary cortical cells with 10-40 µM hydrogen peroxide did not significantly compromise cell viability but it did produce mild oxidative stress (mOS), as shown by the increased levels of reactive radical species and activation of p38 stress kinase. The endogenous levels of BACE1 mRNA and protein were not significantly altered in these conditions, whereas a toxic H2O2 concentration (100 µM) caused an increase in BACE1 protein levels. Notably, mOS conditions resulted in increased levels of the BACE1 C-terminal cleavage product of APP, β-CTF. Subcellular fractionation techniques showed that mOS caused a major rearrangement of BACE1 localization from light to denser fractions, resulting in an increased distribution of BACE1 in fractions containing APP and markers for trans-Golgi network and early endosomes. Collectively, these data demonstrate that mOS does not modify BACE1 expression but alters BACE1 subcellular compartmentalization to favour the amyloidogenic processing of APP, and thus offer new insight in the early molecular events of AD pathogenesis.\n|Alternate Journal||PLoS ONE|", "domain": "chemistry", "round": 3} +{"url": "https://londonstore.lk/shop/skin-care/moisturiser/the-inkey-list-retinol-eye-cream-15ml/", "date": "2023-11-30T07:34:45Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100172.28/warc/CC-MAIN-20231130062948-20231130092948-00890.warc.gz", "language_score": 0.8325574994087219, "token_count": 595, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__55716024", "lang": "en", "text": "The INKEY List under eye Caffeine Serum is rich in an anti-inflammatory antioxidant derived from coffee. It helps to reduce puffiness, dark circles and prevent skin damage from free radicals which can make dark circles more pronounced.\nAs caffeine is a diuretic it can help to relieve water retention which can be a major cause of puffiness under the eyes.\nCaffeine serums acts to:\n– Target dark circles\n– Reduce the appearance of dark circles\n– Reduce puffiness\n– Reduce the appearance of fine lines\n– Matrixyl 3000 peptide to help boost collagen production.\n– Suitable for all skin types.\nUse morning and evening. After cleansing apply a small amount onto finger and gently pat around the contour of the eye. Can be combined with the use of other serums. Follow with moisturiser.\nFor an extra soothing effect, keep your caffeine serum in the fridge and massage gently into the under eye area to stimulate circulation.\nTips from The INKEY List:\nDark circles and puffiness can be caused by a number of factors. If you are genetically predispositioned to dark circles, caused by pigmentation underneath the eye, or puffiness under the eye caused by fat deposits, unfortunately caffeine serum is unlikely to help.\nCaffeine is a fantastic way to reduce puffiness and dark circles caused by a number of lifestyle factors such as lack of sleep, travelling, diet and high salt intake among others. As an antioxidant, it also has preventative properties, and can protect the eye area from free radicals and environmental stress. Ensuring you are always wearing sunscreen will also help.\nAdvice and Warnings:\nAvoid the immediate eye area. External use only.\nWater (Aqua / Eau), Glycerin, Dicaprylyl Carbonate, Propanediol, Polyglyceryl-6 Distearate, Cetyl Alcohol, Hydroxyethyl Acrylate/sodium Acryloyldimethyl Taurate Copolymer, Jojoba Esters, Glyceryl Dibehenate, Albizia Julibrissin Bark Extract, Squalane, Caffeine, Polyglyceryl-3 Beeswax, Phospholipids, Tribehenin, Ethylhexylglycerin, Xanthan Gum, Glycine Soja (Soybean) Extract, Polysorbate 60, Disodium Edta, Glyceryl Behenate, Glycolipids, Butylene Glycol, Glycine Soja (Soybean) Sterol, Leuconostoc/radish Root Ferment Filtrate, Hyaluronic Acid, Carbomer, Darutoside, Polysorbate 20, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-1, Phenoxyethanol.", "domain": "chemistry", "round": 3} +{"url": "http://cyphergate.net/index.php?title=Uced_nicotinamide_adenine_dinucleotide_phosphate_(NADPH;_five_mM)._Reactions_were_being_initiated_by&oldid=56337", "date": "2021-03-02T19:54:05Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-10/segments/1614178364764.57/warc/CC-MAIN-20210302190916-20210302220916-00137.warc.gz", "language_score": 0.8309372067451477, "token_count": 1039, "dump": "CC-MAIN-2021-10", "global_id": "webtext-fineweb__CC-MAIN-2021-10__0__74992026", "lang": "en", "text": "Uced nicotinamide adenine dinucleotide phosphate (NADPH; five mM). Reactions were being initiated by\nSelker, PFI-1 web August 26, 2016 (sent for PFI-3 MSDS assessment Could 5, 2016; reviewed by Sarah Elgin and Mo Motamedi)DNA methylation, heterochromatin protein one (HP1), histone H3 lysine 9 (H3K9) methylation, histone deacetylation, and really recurring sequences are prototypical heterochromatic attributes, but their interrelationships aren't thoroughly understood. (2015) Divergent mechanistic routes to the formation of gem-dimethyl teams from the biosynthesis of complex polyketides. Angew Chem Int Ed Engl fifty four(8): 2370?373. 23. Bracher PJ, Snyder PW, Bohall BR, Whitesides GM (2011) The relative rates of thiolthioester exchange PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/26262685 and hydrolysis for alkyl and aryl thioalkanoates in water. Orig Daily life Evol Biosph forty one(5):399?12.24. Randall SM, Koryakina I, Williams GJ, Muddiman DC (2014) Evaluating nonpolar floor location and liquid chromatography/mass spectrometry reaction: An application for web page occupancy measurements for enzyme intermediates in polyketide biosynthesis. Immediate Commun Mass Spectrom 28(23):2511?522. 25. Tosin M, et al. (2011) In vivo trapping of polyketide intermediates from an assembly line synthase employing malonyl carba(dethia)-N-acetyl cysteamines. Chem Commun (Camb) 47(twelve):3460?462. 26. Riva E, et al. (2014) Chemical probes with the functionalization of polyketide intermediates. Angew Chem Int Ed Engl fifty three(forty four):11944?1949.E668 | www.pnas.org/cgi/doi/10.1073/pnas.Advert et al. Twin chromatin recognition through the histone deacetylase intricate HCHC is required for correct DNA methylation in Neurospora crassaShinji Hondaa,b,1, Vincent T. Bicoccaa,one, Jordan D. Gessamana,one, Michael R. Rountreea,one,two, Ayumi Yokoyamab, Eun Y. Yua, Jeanne M. L. Selkera, and Eric U. Selkera,aInstitute of Molecular Biology, University of Oregon, Eugene, OR 97403; and bFaculty of Clinical Sciences, University of Fukui, Fukui 910-1193, JapanContributed by Eric U. Selker, August 26, 2016 (sent for evaluate May well 5, 2016; reviewed by Sarah Elgin and Mo Motamedi)DNA methylation, heterochromatin protein one (HP1), histone H3 lysine nine (H3K9) methylation, histone deacetylation, and highly repeated sequences are prototypical heterochromatic options, but their interrelationships are usually not entirely comprehended. Prior do the job showed that H3K9 methylation directs DNA methylation and histone deacetylation through HP1 in Neurospora crassa which the histone deacetylase sophisticated HCHC is necessary for correct DNA methylation. The intricate consists of your chromodomain proteins HP1 and chromodomain protein two (CDP-2), the histone deacetylase HDA-1, plus the AT-hook motif protein CDP-2/HDA-1 ssociated protein (CHAP). We show that the sophisticated is necessary for proper chromosome segregation, dissect its operate, and characterize interactions amid its parts. Our analyses discovered the existence of the HP1-based DNA methylation pathway impartial of its chromodomain. The pathway partially is dependent upon CHAP although not to the CDP-2 chromodomain. CDP-2 serves as being a bridge amongst the popularity of H3K9 trimethylation (H3K9me3) by HP1 and also the histone deacetylase exercise of HDA-1. CHAP can be vital for HDA-1 localization to heterochromatin. Precisely, the CHAP zinc finger interacts directly PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/22610350 with the HDA-1 argonaute-binding protein 2 (Arb2) domain, as well as CHAP AT-hook motifs realize heterochromatic locations by binding to Piperlongumine MedChemExpress AT-rich DNA. Our knowledge s.", "domain": "chemistry", "round": 3} +{"url": "http://jddtonline.info/index.php/jddt/article/view/2722", "date": "2019-06-16T17:28:00Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-26/segments/1560627998288.34/warc/CC-MAIN-20190616162745-20190616184745-00037.warc.gz", "language_score": 0.7215288877487183, "token_count": 1519, "dump": "CC-MAIN-2019-26", "global_id": "webtext-fineweb__CC-MAIN-2019-26__0__139632207", "lang": "en", "text": "Synthesis of some new 1,3,5-trisubstituted pyrazoles as antioxidant and antiinflammatory agents\nA series of some new 1,3,5-trisubstituted pyrazoles was synthesized by the reaction of α-β dibromochalcones with phenylhydrazine hydrochloride. α-β-Dibromochalcones were prepared by the regioselective bromination of respective chalcones with tetrabutylammonium tribromide. The synthesized trisubstituted pyrazoles were evaluated for their anti-inflammatory and antioxidant properties.\nKeywords: α-β-Dibromochalcones, 1,3,5-Trisubstituted pyrazoles, Tetrabutylammonium tribromide, Anti-inflammatory and antioxidant activities\n2. Khalid K.; Smaail R.; Youssef R.; Jamal T.; M’hammed A., Synthesis and Pharmacological Activities of Pyrazole Derivatives:A Review., Molecules, 2018; 23:134\n3. Seyed Nasser.;Ostad, A. S., Synthesis and Anticancer Activity of 1, 3, 5-Triaryl-1H-Pyrazole.,Letters in Drug Design & Discovery, 2015; 12(999):1-1.\n4. Mohd J. Naim.; Ozair A.; Farah N.; Md. Jahangir A.; and Perwaiz,A., Current status of pyrazole and its biological activities., J Pharm Bioallied Sci. 2016;Jan-Mar, 8(1):2–17.\n5. Bedia K-K.; Hale Z. T.; Serkan I˙Kiz.; A. Funda B.; Sevim R.; N.Yakut O. & Seyyal AK., Synthesis and antinociceptive-antimicrobial activities of some new amide derivatives of 3,5-di/-and 1,3,5-trimethylpyrazoles., Journal of Enzyme Inhibition and Medicinal Chemistry, August 2008; 23(4):454–461\n6. Magda M. F. I.; Nagy M. Khalifa., Hoda H. F.; Hend M. EL-S.; Eman, S.N., Anticancer evaluation of novel 1,3,4-trisubstituted pyrazole candidates bearing different nitrogenous heterocyclic Moieties., Biomedical Research.;2016; 27(4):1087-1093\n7. Mukherjee A.; Sarkar A.; Pyrazole-based P,N-ligand for palladium catalyst: applications in Suzuki coupling and amination reactions; Arkivoc.; 2003; 9:87\n8. Sanz D.; Jimenez J. A.; Claramunt R. M.; Elguero, Multidentate Ligands from N-hydroxy and N-methyl Pyrazole J. Arkivoc, 2004; 4:100\n9. Kobayashi T.; Uchiyama Y.; Neighboring effect of pyrazole rings: regio- and stereoselective Wagner–Meerwein rearrangement in electrophilic addition reactions of norbornadiene-fused pyrazoles.; J. Chem. Soc., 2000; 2731\n10. Novinson, T.; Robins, R. K.; Matthews, T. R.; Synthesis and Biological Evaluation of the 1,5-Diarylpyrazole Class of Cyclooxygenase-2 Inhibitors: Identification of 4-[5-(4-Methylphenyl)-3- (trifluoromethyl)-1H-pyrazol-1-yl]benzenesulphonamide.; J. Med. Chem., 1997; 40(9):1347-1365\n11. David F. Farrell., Chalcone derivatives as precursors of 1,2,3,4 tetrahydoquinolones.,Tetrahedron. 1990; 46(3):885-894\n12. Litkei D; Khilya VP; A. L. Tokesh; Antush; A. V. Turo.; Reaction of chalcones with N-bromosuccinimide.,Chemistry of Heterocyclic Compounds.;1995; 31(4):432–440\n13. Khurana J.M., Maikap G. C.; Sahoo P. K.; Stereoselective Debromination of vic-Dibromides to E-Alkenes with Dimethylformamide., Synthesis, 1991; 10:827-828.\n14. Vijayshree N.; Samuelson A. G.; Selective debromination of activated vicinal dibromides by copper promoted by copper (II); Tetrahedron Lett., 1992, 33 (4):559-560.\n15. Ranu B. C.; Jana R. Catalysis by Ionic Liquid; A Green Protocol for the Stereoselective Debromination of vicinal-Dibromides by [pmIm] BF4 under Microwave Irradiation; J. Org. Chem., 2005; 70 (21):8621-8624.\n16. Donnely J.A and Higginbotham C.L; Flavone formation in the wheeler Aurone Synthesis; Tetrahedron.; 1990; 46:7219.\n17. Shoji K; Takaaki K; Tsuyoshi O; Shizuo F; Synthesis of Bromoacetyl Derivatives by use of tetrabutylammonium tribromide; Bull. Chem. Soc. Jpn.; 1987; 60:1159-1160\n18. Berthelot J; Benammar Y; Desmazieres, B.; Action of tetrabutylammonium tribromide with para-substituted chalcones in protic and aprotic media; Can. J. Chem.; 1995; 73:1526-1530.\nThis work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.\nAuthors who publish with this journal agree to the following terms:\n- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.\n- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.\n- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).", "domain": "chemistry", "round": 3} +{"url": "https://www.slideserve.com/libitha/diazonium-salts-synthesis", "date": "2019-01-17T18:14:44Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-04/segments/1547583659056.44/warc/CC-MAIN-20190117163938-20190117185938-00190.warc.gz", "language_score": 0.8027780055999756, "token_count": 382, "dump": "CC-MAIN-2019-04", "global_id": "webtext-fineweb__CC-MAIN-2019-04__0__165274035", "lang": "en", "text": "Diazonium salts synthesis. benzenediazonium ion. Diazonium salts, reactions Coupling to form azo dyes Replacements a) -Br, -Cl, -CN b) -I c) -F d) -OH e) -H f) etc. coupling to form azo dyes. Sandmeyer. Ar-N 2 + + CuCl Ar-Cl + N 2\nDownload Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.\nAr-N2+ + CuCl Ar-Cl + N2\nAr-N2+ + CuBr Ar-Br + N2\nAr-N2+ + CuCN Ar-CN + N2\nAr-N2+ + HBF4 Ar-F + N2\nAr-N2+ + H2O, H+ Ar-OH + N2\nAr-N2+ + H3PO2 Ar-H + N2\nIn syntheses, you may no longer assume that you can separate a pure para isomer from an ortho/para mixture. Either look up the physical properties of the compounds or rely on experience gained in the homework as to which mixtures are separable and which ones are not!\nInfrared: N—H stretch 3200 – 3500 cm-1\n1o often two bands 2o one band 3o no bands\n1o strong bands 650-900 cm-1(broad) and 1560-1650 cm-1\nnmr: N—H 1-5 ppm (often broad and low)\nd c b a", "domain": "chemistry", "round": 3} +{"url": "https://cmapspublic2.ihmc.us/rid=1K27DLKKK-1K3ZC1V-12JQ/Ethel%20Kardashian.cmap", "date": "2021-06-20T12:33:15Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-25/segments/1623487662882.61/warc/CC-MAIN-20210620114611-20210620144611-00251.warc.gz", "language_score": 0.8804893493652344, "token_count": 251, "dump": "CC-MAIN-2021-25", "global_id": "webtext-fineweb__CC-MAIN-2021-25__0__212211695", "lang": "en", "text": "work until it is reactivated.\nThis Concept Map, created with IHMC CmapTools, has information related to: Ethel Kardashian, Excessive alcohol limits absorbtion of Thiamine, Excessive alcohol metabilized by Alcohol Dehydrogenase, Increased NADH which inhibits Pyruvate dehydrogenase, Ethel Kardashian 45 y/o female whose lifestyle choices include demanding work schedule, Glycerol which is used for Triglyceride Synthesis, Low Hemoglobin indicates Anemia, elevated MCV indicates Macrocytosis, lactate dehydrogenase converting Pyruvate, oxaloacetate to malate, Ethel Kardashian 45 y/o female diagnostic studies show Low Hemoglobin, Thiamine decreases Metabolic Processes, Anemia contributes to Macrocytosis, acetaldehyde dehydrogenase results in Increased NADH, oxaloacetate are intermediates for Pyruvate, Triglyceride Synthesis ???? ????, Intermediates that are used for production Glycerol, lactate Leading to Lactic Acidosis, malate dehydrogenase converting oxaloacetate, Glycolysis has Intermediates, Alcohol Dehydrogenase results in Increased NADH", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/ctr9-antibody-ab101459.html", "date": "2020-08-03T21:05:19Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-34/segments/1596439735833.83/warc/CC-MAIN-20200803195435-20200803225435-00377.warc.gz", "language_score": 0.6746598482131958, "token_count": 451, "dump": "CC-MAIN-2020-34", "global_id": "webtext-fineweb__CC-MAIN-2020-34__0__30980870", "lang": "en", "text": "Key features and details\n- Rabbit polyclonal to CTR9\n- Suitable for: WB, IHC-P\n- Reacts with: Human\n- Isotype: IgG\nProduct nameAnti-CTR9 antibody\nSee all CTR9 primary antibodies\nDescriptionRabbit polyclonal to CTR9\nTested applicationsSuitable for: WB, IHC-Pmore details\nSpecies reactivityReacts with: Human\nPredicted to work with: Mouse, Rat, Zebrafish\nRecombinant fragment corresponding to a region within amino acids 24-169 of Human CTR9 (AAH58914).\n- A431 whole cell lysate; 293T, Jurkat and Raji cell lysates; Cal27 xenograft\nStorage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.\nStorage bufferpH: 7.00\nPreservative: 0.025% Proclin 300\nConstituents: PBS, 1% BSA, 20% Glycerol\nConcentration information loading...\nPurityImmunogen affinity purified\nOur Abpromise guarantee covers the use of ab101459 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\n|WB||1/500 - 1/3000. Predicted molecular weight: 134 kDa.|\n|IHC-P||1/100 - 1/500. Perform heat mediated antigen retrieval before commencing with IHC staining protocol. Use 10mM citrate buffer or Tris-EDTA buffer (pH 8.0).|\nTissue specificityWidely expressed.\nSequence similaritiesContains 16 TPR repeats.\nCellular localizationNucleus speckle. Found in speckles.\n- Information by UniProt\n- Ctr 9 antibody\n- CTR9 antibody\n- Ctr9 Paf1/RNA polymerase II complex component, homolog antibody\nab101459 has not yet been referenced specifically in any publications.", "domain": "chemistry", "round": 3} +{"url": "https://envcoglobal.com/catalog/water/water-quality-loggers/multiparameter-instruments/ysi-exo/exo-total-algae-sensor", "date": "2019-10-14T15:44:02Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-43/segments/1570986653876.31/warc/CC-MAIN-20191014150930-20191014174430-00292.warc.gz", "language_score": 0.8216930031776428, "token_count": 586, "dump": "CC-MAIN-2019-43", "global_id": "webtext-fineweb__CC-MAIN-2019-43__0__1073164", "lang": "en", "text": "You are here\nEXO Total Algae sensor\nThe EXO total algae sensor is a dual-channel fluorescence sensor that generates two independent data sets; one resulting from a blue excitation beam that directly excites the chlorophyll a molecule, present in all photosynthetic cells, and a second from an orange excitation beam that excites the phycocyanin accessory pigment found in blue-green algae (cyanobacteria). This orange excitation triggers a transfer of energy from the phycocyanin to the central chlorophyll a, where photosynthesis is initiated. Although blue-green algae contain chlorophyll a, the chlorophyll fluorescence signal detected by in situ fluorometers is weaker than in eukaryotic phytoplankton. This results in an underestimate of algae biomass when using a single-channel chlorophyll sensor when blue-green algae are present. The EXO total algae sensor generates a more accurate total biomass estimate of the planktonic autotrophic community by exciting chlorophyll a and phycocyanin.\nBGA probes and Chlorophyll probes have been combined into a single sensor\nA change with the EXO platform will be the BGA probes and Chlorophyll probes have been combined into a single sensor. There is no option to purchase one or the other.\nThis sensor is referred to as the “Total Algae” Sensor because having both chlorophyll and algae are important for estimating the total algae bio mass; the sensor will still output a BGA reading and a Chlorophyll reading independently.\nBlue-green Algae Phycocyanin\nRange: 0 to 100 μg/L; 0 to 100 RFU;\nLinearity: R2 >0.999 for serial dilution of Rhodamine WT solution from 0 to 100 μg/mL BGA-PC equivalents\nDetection Limit: 0.04 μg/L PC\nResponse: T63<2 sec\nResolution: 0.01 μg/L; 0.01 RFU\nRange: 0 to 400 μg/L Chl; 0 to 100 RFU\nLinearity: R2 >0.999 for serial dilution of Rhodamine WT solution from 0 to 400 μg/L Chl a equivalents\nDetection Limit: 0.09 μg/L Chl\nResponse: T63<2 sec\nResolution: 0.01 μg/L Chl; 0.01 RFU\n599102-01 EXO Total Algae - PC Sensor, Ti \"EXO Total Algae - PC Sensor, Ti\n- Optimised for freshwater use - Phycocyanin\n- Includes chlorophyll and blue green algae sensors in a single Sensor\n- Incorporates wet-mate connector and sealed welded titanium design\"", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/cortactin-antibody-ep1922y-pe-ab209758.html", "date": "2020-08-05T19:27:58Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-34/segments/1596439735964.82/warc/CC-MAIN-20200805183003-20200805213003-00144.warc.gz", "language_score": 0.765291154384613, "token_count": 995, "dump": "CC-MAIN-2020-34", "global_id": "webtext-fineweb__CC-MAIN-2020-34__0__28566603", "lang": "en", "text": "Key features and details\n- Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply\n- Rabbit monoclonal [EP1922Y] to Cortactin (PE)\n- Suitable for: Flow Cyt\n- Conjugation: PE. Ex: 488nm, Em: 575nm\nProduct nameAnti-Cortactin antibody [EP1922Y] (PE)\nSee all Cortactin primary antibodies\nDescriptionRabbit monoclonal [EP1922Y] to Cortactin (PE)\nConjugationPE. Ex: 488nm, Em: 575nm\nTested applicationsSuitable for: Flow Cytmore details\nPredicted to work with: Mouse, Rat, Human\nSynthetic peptide within Human Cortactin aa 1-100 (N terminal). The exact sequence is proprietary.\nDatabase link: Q14247\n- Flow Cyt: HeLa cells.\nOur RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents.\nStorage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at +4°C. Do Not Freeze. Store In the Dark.\nStorage bufferpH: 7.40\nPreservative: 0.02% Sodium azide\nConstituents: 1% BSA, PBS\nConcentration information loading...\nPurityProtein A purified\n- Anti-Cortactin antibody [EP1922Y] (Alexa Fluor® 488) (ab202648)\n- Anti-Cortactin antibody [EP1922Y] (Alexa Fluor® 647) (ab202650)\n- Anti-Cortactin antibody [EP1922Y] (Alexa Fluor® 555) (ab215298)\n- Anti-Cortactin antibody [EP1922Y] (Alexa Fluor® 568) (ab215299)\n- Anti-Cortactin antibody [EP1922Y] (Alexa Fluor® 594) (ab215300)\n- Anti-Cortactin antibody [EP1922Y] - BSA and Azide free (ab223125)\n- Anti-Cortactin antibody [EP1922Y] (ab81208)\nOur Abpromise guarantee covers the use of ab209758 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\nFunctionContributes to the organization of the actin cytoskeleton and cell structure. Plays a role in the regulation of cell migration. Plays a role in the invasiveness of cancer cells, and the formation of metastases.\nSequence similaritiesContains 7 cortactin repeats.\nContains 1 SH3 domain.\nDomainThe SH3 motif may mediate binding to the cytoskeleton.\nmodificationsTyrosine phosphorylation in transformed cells may contribute to cellular growth regulation and transformation.\nCellular localizationCytoplasm > cytoskeleton. Cell projection > lamellipodium. Cell projection > ruffle. Associated with membrane ruffles and lamellipodia.\n- Information by UniProt\n- Amplaxin antibody\n- CTTN antibody\n- EMS 1 antibody\nOverlay histogram showing HeLa cells stained with ab209758 (red line). The cells were fixed with 4% formaldehyde (10 min) and then permeabilized with 0.1% PBS-Triton X-100 for 15 min. The cells were then incubated in 1x PBS / 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (ab209758, 1/5000 dilution) for 30 min at 22°C. Isotype control antibody (black line) was rabbit IgG (monoclonal) Phycoerythrin (ab209478) used at the same concentration and conditions as the primary antibody. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 50mW Yellow/Green laser (561nm) and 586/15 bandpass filter. This antibody gave a positive signal in HeLa cells fixed with 80% methanol (5 min)/permeabilized with 0.1% PBS-Triton X-100 for 15 min used under the same conditions.\nab209758 has not yet been referenced specifically in any publications.", "domain": "chemistry", "round": 3} +{"url": "http://jcoagri.uobaghdad.edu.iq/index.php/intro/article/view/664", "date": "2020-11-24T03:00:35Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-50/segments/1606141171077.4/warc/CC-MAIN-20201124025131-20201124055131-00411.warc.gz", "language_score": 0.9165977239608765, "token_count": 467, "dump": "CC-MAIN-2020-50", "global_id": "webtext-fineweb__CC-MAIN-2020-50__0__121344237", "lang": "en", "text": "ROLE OF SPRAYING BORON AND SUGAR ALCOHOLS ON GROWTH, YIELD AND SEEDS PRODUCTION OF PEPPER\nThe objective of this experiment was to investigate the effect of boron and sugar alcohols on the growth, yield and quantity of seeds produced from pepper cv. California wonder, A factorial experiment (3 × 7) was conducted according to randomized complete block design (RCBD) with three replications at the open field of the research station B, Coll. of Agri. Univ. of Baghdad during 20/12/2016 to 1/12/2017. The experiment included two factors, first one was boron which used boric acid (0, 50, 100 mg l -1) and the second factor was sugar alcohols (sorbitol) (15, 25, 35 g, l -1) and mannitol sugar (10, 20, and 30 g l -1) in addition to control treatment ( spraying with water), Results showed significant superiority of boron with concentration 100 mg l -1 in the plant high (58.60 cm), number of main branches plant-1 (7.52 branch), leaves area (1129.9 dcm2 plant-1), number of fruits plant-1 (49.43 fruit) and total yield (148.64 ton ha-1). Significant superiority of mannitol with concentration 30 mg l -1 was found in the plant height (60.34cm), number of main branches (7.33 branch plant-1), leaves area (1237.8 dcm2), total chlorophyll content (302.11 mg g-1 fresh weight), fruit weight (96.27 g fruit-1), number of fruits (50.84 fruit plant-1), total yield (158.39 ton ha-1) seeds germination (91.66%), speed of germination (4.67 day). The interaction between two variables was significant for all the studied traits, this showed that the response of pepper to first variable related to the other variable. It could be concluded that the best combination between two variable was boron (100 mg l-1) and sugar alcohols (mannitol 30 g l-1).", "domain": "chemistry", "round": 3} +{"url": "https://www.thermofisher.com/antibody/product/ATP6V0A2-Antibody-Polyclonal/PA5-29271", "date": "2017-01-19T05:30:42Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-04/segments/1484560280483.83/warc/CC-MAIN-20170116095120-00510-ip-10-171-10-70.ec2.internal.warc.gz", "language_score": 0.6966974139213562, "token_count": 607, "dump": "CC-MAIN-2017-04", "global_id": "webtext-fineweb__CC-MAIN-2017-04__0__75975743", "lang": "en", "text": "Note: You clicked on an external link, which has been disabled in order to keep your shopping session open.\n|Tested species reactivity||Human|\n|Host / Isotype||Rabbit / IgG|\n|Immunogen||Recombinant fragment corresponding to a region within amino acids 81 and 349 of Human ATP6V0A2|\n|Purification||Antigen affinity chromatography|\n|Storage buffer||0.1M tris glycine, pH 7, with 20% glycerol|\n|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|\n|Tested Applications||Dilution *|\n|Western Blot (WB)||1:500-1:3000|\n* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.\nPA5-29271 targets ATP6V0A2 in WB applications and shows reactivity with Human samples.\nThe PA5-29271 immunogen is recombinant fragment corresponding to a region within amino acids 81 and 349 of Human ATP6V0A2.\nThe multisubunit vacuolar-type proton pump (H(+)-ATPase or V-ATPase) is essential for acidification of diverse cellular components, including endosomes, lysosomes, clathrin-coated vesicles, secretory vesicles, and chromaffin granules, and it is found at high density in the plasma membrane of certain specialized cells. H(+)-ATPases are comprised of a peripheral V(1) domain and an integral membrane V(0) domain; ATP6V0A2 is a component of the V(0) domain (Smith et al., 2003 [PubMed 14580332]).\nFor Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.\nA2V-ATPase; ARCL; ARCL2A; ATP6A2; ATP6N1D; ATPase, H+ transporting, lysosomal V0 subunit a2; J6B7; lysosomal H(+)-transporting ATPase V0 subunit a2; regeneration and tolerance factor; RTF; STV1; TJ6M; TJ6S; v-ATPase 116 kDa; v-type proton ATPase 116 kDa subunit a; vacuolar proton translocating ATPase 116 kDa subunit a; VPH1; WSS\nA2; ARCL; ARCL2A; ATP6A2; ATP6N1D; ATP6V0A2; J6B7; RTF; STV1; TJ6; TJ6M; TJ6S; VPH1; WSS", "domain": "chemistry", "round": 3} +{"url": "https://www.woundcarehandbook.com/companies/advanced-medical-solutions/activheal-silicone-foam-border/", "date": "2022-11-29T22:01:20Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-49/segments/1669446710711.7/warc/CC-MAIN-20221129200438-20221129230438-00571.warc.gz", "language_score": 0.8124833106994629, "token_count": 344, "dump": "CC-MAIN-2022-49", "global_id": "webtext-fineweb__CC-MAIN-2022-49__0__123218377", "lang": "en", "text": "ActivHeal Silicone Foam Border\nA sterile absorbent dressing consisting of a hydrophilic polyurethane foam pad, without and without a border. The outer layer comprises a pink, low-friction, waterproof, polyurethane film. The perforated, silicone, adhesive wound contact layer enables exudate uptake and prevents the dressing from sticking to the wound.\nModerately to heavily exuding wounds such as venous and arterial leg ulcers, diabetic foot ulcers, postoperative wounds. Can be used as a secondary dressing on cavity wounds and under compression bandaging.\nDry or lightly exuding wounds. Do not use on individuals with a known sensitivity to polyurethane films, foams or silicone, or with full-thickness burns.\nBorder: 7.5x7.5cm; 10x10cm; 12.5x12.5cm; 15x15cm; 20x20cm; 10x20cm 18x18.5cm (sacral)\nNon-border: 5x5cm; 7.5x7.5cm; 10x10cm; 15x15cm; 20x20cm; 10x20cm\nBorder: £1.08; £1.64; £2.35; £2.88; £4.97; £2.92; £3.65\nNon-border: £0.84; £0.98; £1.45; £2.67; £4.29; £2.69\nMore on: Foams", "domain": "chemistry", "round": 3} +{"url": "https://www.synergy-munich.de/publications/2018/gruber.html", "date": "2020-11-24T17:22:35Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-50/segments/1606141176922.14/warc/CC-MAIN-20201124170142-20201124200142-00509.warc.gz", "language_score": 0.818059504032135, "token_count": 383, "dump": "CC-MAIN-2020-50", "global_id": "webtext-fineweb__CC-MAIN-2020-50__0__164807350", "lang": "en", "text": "Molecular and structural architecture of polyQ aggregates in yeast.\nProc Natl Acad Sci U S A. 2018 Mar 26. pii: 201717978. doi: 10.1073/pnas.1717978115. [Epub ahead of print]\n|Authors/Editors:||Gruber A, Hornburg D, Antonin M, Krahmer N, Collado J, Schaffer M, Zubaite G, Lüchtenborg C, Sachsenheimer T, Brügger B, Mann M, Baumeister W, Hartl FU, Hipp MS, Fernández-Busnadiego R.|\nHuntington's disease is caused by the expansion of a polyglutamine (polyQ) tract in the N-terminal exon of huntingtin (HttEx1), but the cellular mechanisms leading to neurodegeneration remain poorly understood. Here we present in situ structural studies by cryo-electron tomography of an established yeast model system of polyQ toxicity. We find that expression of polyQ-expanded HttEx1 results in the formation of unstructured inclusion bodies and in some cases fibrillar aggregates. This contrasts with recent findings in mammalian cells, where polyQ inclusions were exclusively fibrillar. In yeast, polyQ toxicity correlates with alterations in mitochondrial and lipid droplet morphology, which do not arise from physical interactions with inclusions or fibrils. Quantitative proteomic analysis shows that polyQ aggregates sequester numerous cellular proteins and cause a major change in proteome composition, most significantly in proteins related to energy metabolism. Thus, our data point to a multifaceted toxic gain-of-function of polyQ aggregates, driven by sequestration of endogenous proteins and mitochondrial and lipid droplet dysfunction.", "domain": "chemistry", "round": 3} +{"url": "https://www.antikoerper-online.de/jak-stat-signalweg-pathway-6/agt-elisa-kit-288/", "date": "2018-01-17T10:43:08Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-05/segments/1516084886895.18/warc/CC-MAIN-20180117102533-20180117122533-00587.warc.gz", "language_score": 0.7266581058502197, "token_count": 3045, "dump": "CC-MAIN-2018-05", "global_id": "webtext-fineweb__CC-MAIN-2018-05__0__177080726", "lang": "en", "text": "Use your antibodies-online credentials, if available.\nKeine Produkte auf Ihrer Vergleichsliste.\nIhr Warenkorb ist leer.\nAlle Spezies anzeigen\nWeitere Synonyme anzeigen\nSelect your species\nHuman AGT ELISA Kit für Competition ELISA - ABIN1979311\nAzibani, Devaux, Coutance, Schlossarek, Polidano, Fazal, Merval, Carrier, Solal, Chatziantoniou, Launay, Samuel, Delcayre: Aldosterone inhibits the fetal program and increases hypertrophy in the heart of hypertensive mice. in PLoS ONE 2012\nShow all 16 Pubmed References\nHuman AGT ELISA Kit für Sandwich ELISA - ABIN414452\nKutlugün, Altun, Aktan, Turkmen, Altindal, Yildirim, Yilmaz, Arici, Erdem, Turgan: The relation between urinary angiotensinogen and proteinuria in renal AA amyloidosis patients. in Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 2012\nShow all 8 Pubmed References\nHuman AGT ELISA Kit für Competition ELISA - ABIN1979317\nKovats: Climate change, crop yields, and undernutrition, with Sari Kovats by Ashley Ahearn. in Environmental health perspectives 2012\nShow all 3 Pubmed References\nHuman AGT ELISA Kit für Sandwich ELISA - ABIN364992\nMao, Cao, Lan, He, Chen, Wang, Hu, Lv, Wang, Yan: Therapeutic effect of forest bathing on human hypertension in the elderly. in Journal of cardiology 2012\nShow all 2 Pubmed References\nHuman AGT ELISA Kit für Competition ELISA - ABIN1979314\nShigemura, Iwata, Yasumatsu, Ohkuri, Horio, Sanematsu, Yoshida, Margolskee, Ninomiya: Angiotensin II modulates salty and sweet taste sensitivities. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2013\nRat (Rattus) AGT ELISA Kit für Competition ELISA - ABIN416134\nEl-Sayed, Moustafa, El-Azab: Evening primrose oil and celecoxib inhibited pathological angiogenesis, inflammation, and oxidative stress in adjuvant-induced arthritis: novel role of angiopoietin-1. in Inflammopharmacology 2014\nRat (Rattus) AGT ELISA Kit für Sandwich ELISA - ABIN431407\nWang, Long, Chen, Cui, Zhang, Zhang, Wang: Pharmacological evidence: a new therapeutic approach to the treatment of chronic heart failure through SUR2B/Kir6.1 channel in endothelial cells. in Acta pharmacologica Sinica 2016\nHuman AGT ELISA Kit für Competition ELISA - ABIN2683373\nFernando, Chandramouli, Rosli, Lam, Yong, Yaw, Ton, Kadir, Sainsbury: Glycyrrhizic acid can attenuate metabolic deviations caused by a high-sucrose diet without causing water retention in male Sprague-Dawley rats. in Nutrients 2014\nRat (Rattus) AGT ELISA Kit für Sandwich ELISA - ABIN368250\nZhao, Wang, Wang, Ma, Zhou, Deng: The role of KCa3.1 channels in cardiac fibrosis induced by pressure overload in rats. in Pflu?gers Archiv : European journal of physiology 2015\npresent study has demonstrated, for the first time, that high glucose augments AGT (zeige AGXT ELISA Kits) in human RPTCs through HNF-5, which provides a potential therapeutic target for diabetic nephropathy\nAngII-dependent phosphorylation of LCP1 (zeige LCP1 ELISA Kits) in cultured podocytes was mediated by the kinases ERK (zeige EPHB2 ELISA Kits), p90 (zeige CANX ELISA Kits) ribosomal S6 kinase (zeige RPS6KB1 ELISA Kits), PKA, or PKC. LCP1 (zeige LCP1 ELISA Kits) phosphorylation increased filopodia formation.\nAutosomal dominant polycystic kidney disease (ADPKD), uniquely increases urinary angiotensinogen and renin (zeige REN ELISA Kits) excretion despite their circulating levels being comparable with those in non-ADPKD chronic kidney disease.\nQuaternary interactions and supercoiling modulate the cooperative DNA binding of AGT (zeige AGXT ELISA Kits).\nresults show that SNPs in the Hap (zeige SAFB ELISA Kits)-I of the hAGT gene promote high-fat diet-induced binding of transcription factors GR, CEBP-beta (zeige CEBPB ELISA Kits) and STAT3 (zeige STAT3 ELISA Kits), which lead to elevated expression of the hAGT gene in hepatic and adipose tissues\nAngiotensinogen import and subsequent trafficking to the mitochondria occurs in proximal kidney tubules.\nTransgenic mice expressing human AGT (zeige AGXT ELISA Kits) in the subfornical organ AGT (zeige AGXT ELISA Kits) and possibly ANG I/ANG II into the cerebral ventricles.\nAngII could induce pulmonary injury by triggering endothelial barrier injury, and such process may be related to the dephosphorylation of Y685-VE-cadherin (zeige CDH5 ELISA Kits) and the endothelial skeletal rearrangement\nRenin-angiotensin system transgenic mouse model suggests that renal injury in preeclampsia may be mediated through local VEGF.\nendoplasmic reticulum stress induces apoptosis in human alveolar epithelial cells through mediation of unfolded protein response pathways, which in turn regulate the autocrine ANGII/ANG1 (zeige ANGPT1 ELISA Kits)-7 system.\nLung ischemia-reperfusion injury causes a dysregulation of circulating Ang 2 (zeige ANGPT2 ELISA Kits) levels and plasma PREP (zeige PREP ELISA Kits) activity, although no direct link between both phenomena could be shown.\nInhibition of TLR4 (zeige TLR4 ELISA Kits) ameliorates AngII-impaired cavernosal relaxation, decreases TNF-alpha (zeige TNF ELISA Kits) levels, and restores Nitric Oxide bioavailability, demonstrating that TLR4 (zeige TLR4 ELISA Kits) partly mediates AngII-induced cavernosal dysfunction.\nOur study is the first to show the important role of IL-6 (zeige IL6 ELISA Kits) in regulating cardiac pathogenesis via inflammation and apoptosis during AngII-induced hypertension. We also provide a novel link between IL-6 (zeige IL6 ELISA Kits)/STAT3 (zeige STAT3 ELISA Kits) and EndoG (zeige ENDOG ELISA Kits)/MEF2A (zeige MEF2A ELISA Kits) pathway that affects cardiac hypertrophy during AngII stimulation.\nthis study demonstrated that Ang II could increase TRPC6 (zeige TRPC6 ELISA Kits) induced Ca(2 (zeige CA2 ELISA Kits)+) influx and enhance autophagy through increasing reactive oxygen species levels in podocytes, and autophagy could protect Ang II-treated podocytes.\nSnell, GHKRO, and PAPPA (zeige PAPPA ELISA Kits)-KO mice express high levels of two proteins involved in DNA repair, O-6-methylguanine-DNA methyltransferase (MGMT (zeige MGMT ELISA Kits)) and N-myc downstream-regulated gene 1 (NDRG1 (zeige NDRG1 ELISA Kits)).\nThese results implied that AngII could effectively induce EpiCs to differentiate into vascular smooth muscle-like cells through the AT1 receptor (zeige AGTRAP ELISA Kits).\nResults suggest the involvement of angiotensin II (Ang II), through its angiotensin type-1 receptor (AT1R (zeige AGTRAP ELISA Kits)) in the inflammation induced by Aah (zeige ASPH ELISA Kits) venom, in the heart and the aorta.\nAngiotensin II stimulates PYY secretion, in turn inhibiting epithelial anion fluxes, thereby reducing net fluid secretion into the colonic lumen.\nexpression of spinal ACE (zeige ACE ELISA Kits) increased in streptozotocin-induced diabetic mice, which in turn led to an increase in Ang II levels and tactile allodynia.\nthe beneficial actions of insulin (zeige INS ELISA Kits) in diabetic nephropathy appear to be mediated, in part, by suppressing renal Nrf2 (zeige NFE2L2 ELISA Kits) and Agt (zeige AGXT ELISA Kits) gene transcription and preventing Nrf2 (zeige NFE2L2 ELISA Kits) stimulation of Agt (zeige AGXT ELISA Kits) expression via hnRNP F (zeige HNRNPF ELISA Kits)/K.\nNADPH oxidase (zeige NOX1 ELISA Kits) plays an important role in proMMP-2 expression and activation and MMP-2 (zeige MMP2 ELISA Kits) mediated SMC (zeige DYM ELISA Kits) proliferation occurs through the involvement of Spm (zeige NPC1 ELISA Kits)-Cer (zeige CBLN1 ELISA Kits)-S1P (zeige MBTPS1 ELISA Kits) signaling axis under ANG II stimulation of PASMCs\nThe metabolism of angiotensin II (Ang II) to angiotensin III (Ang III) and its role in the vasorelaxation response in adrenal arteries are reported.\nThe study identified the serine phosphorylation (p-Ser (zeige SIGLEC1 ELISA Kits)) sites induced by PKC-Beta (zeige PRKCB ELISA Kits) activation or AGT, which inhibits insulin (zeige INS ELISA Kits)-induced p-Tyr (zeige TYR ELISA Kits) sites on IRS2 (zeige IRS2 ELISA Kits) and its signals in endothelial cells.\nData suggest up-regulation of AGT in granulosa cells and of Ang II in follicular fluid during preovulatory period; Ang II appears to amplify stimulatory effects of luteinizing hormone on secretion of progesterone/prostaglandins by granulosa cells.\nData suggest that angiotensin II promotes uptake/accumulation of iron (non-transferrin (zeige Tf ELISA Kits) bound iron) into vascular endothelial cells; such iron accumulation appears to depend on activation of angiotensin type 1 receptor and promotes oxidative stress.\na critical role for H(2)O(2) in angiotensin-II signaling to the endothelial cytoskeleton in a novel pathway that is critically dependent on MARCKS, Rac1, and c-Abl.\nThe objective of this study was to characterize the profiles of Ang-(1-7), MAS receptor, ACE(2), NEP and PEP during the ovulatory process in cattle.\nFetal adrenal cells in primary culture respond to angiotensin-II by increasing aldosterone production and aldosterone synthase (zeige CYP11B2 ELISA Kits) [P450c18/CYP11B2 (zeige CYP11B2 ELISA Kits)] activity.\nANG II inhibits bTREK-1 K(+) channels by a Ca(2+)-dependent mechanism that does not require the depletion of membrane-associated PIP(2).\nprostaglandin F2alpha, endothelin-1 (zeige EDN1 ELISA Kits), and angiotensin II may interact with each other in a local positive feedback manner to activate their secretion in the regressing corpus luteum, thus accelerating and completing luteolysis\nThe protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease.\nalpha-1 antiproteinase, antitrypsin\n, angiotensin I\n, angiotensin II\n, serine (or cysteine) proteinase inhibitor\n, serpin A8\n, angiotensin ll\n, angiotensinogen (PAT)\n, zC8A9.1 (angiotensinogen )\n, Serpin A8\n, alanine--glyoxylate aminotransferase\n, angiotensin receptor 2\n, serine--pyruvate aminotransferase, mitochondrial\n, serine--pyruvate aminotransferase, peroxisomal\n, serine-pyruvate aminotransferase\n, serine:pyruvate aminotransferase SPT\n, serine:pyruvate/alanine:glyoxylate aminotransferase\n, 6-O-methylguanine-DNA methyltransferase\n, O-6-alkylguanine-DNA alkyltransferase\n, methylated-DNA--protein-cysteine methyltransferase", "domain": "chemistry", "round": 3} +{"url": "http://www.creativebiomart.net/Recombinant-Human-ADIPOQ-protein-His-tagged-467877.htm", "date": "2017-04-25T04:58:19Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-17/segments/1492917120101.11/warc/CC-MAIN-20170423031200-00280-ip-10-145-167-34.ec2.internal.warc.gz", "language_score": 0.848517894744873, "token_count": 347, "dump": "CC-MAIN-2017-17", "global_id": "webtext-fineweb__CC-MAIN-2017-17__0__260181385", "lang": "en", "text": "Recombinant Human ADIPOQ(106-242aa) fused with His tag at C-terminal was expressed in Insect cells.\nADIPOQ, as known as adiponectin, is an adipocyte-derived protein with wide ranging paracrine and dedocrine effects on metabolism and inflammation. It is induced during adipocyte differentiation, and its secretion is stimultated by insulin. This protein influences gonadotropin release, normal pregnancy, and assisted reproduction outcomes. Also, it is important factor in chronic liver diseases and chronic kidney diseases.\nLiquid. In Phosphate Buffered Saline (pH 7.4) containing 10% glycerol.\n13.5-18kDa (SDS-PAGE under reducing conditions.)\nADPEGAYVYR SAFSVGLETY VTIPNMPIRF TKIFYNQQNH YDGSTGKFHC NIPGLYYFAY HITVYMKDVK VSLFKKDKAM LFTYDQYQEN NVDQASGSVL LHLEVGDQVW LQVYGEGERN GLYADNDNDS TFTGFLLYHD HHHHHH\n< 1.0 EU per 1 microgram of protein (determined by LAL method)\n> 95% by SDS - PAGE\nCan be stored at +4 centigrade short term (1-2 weeks). For long term storage, aliquot and store at -20 centigrade or -70 centigrade. Avoid repeated freezing and thawing cycles.\n0.5mg/ml (determined by Absorbance at 280nm)", "domain": "chemistry", "round": 3} +{"url": "https://iovs.arvojournals.org/article.aspx?articleid=2159407", "date": "2019-10-16T01:06:07Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-43/segments/1570986660829.5/warc/CC-MAIN-20191015231925-20191016015425-00407.warc.gz", "language_score": 0.9193347692489624, "token_count": 330, "dump": "CC-MAIN-2019-43", "global_id": "webtext-fineweb__CC-MAIN-2019-43__0__49143013", "lang": "en", "text": "Purchase this article with an account.\nB Matsumoto, D Bok; Diurnal variations in amino acid incorporation into inner segment opsin.. Invest. Ophthalmol. Vis. Sci. 1984;25(1):1-9.\nDownload citation file:\n© ARVO (1962-2015); The Authors (2016-present)\nPolyacrylamide gel and immunoelectrophoresis were used to measure the specific activity of nascent inner segment opsin following injections of labeled amino acids into frogs at different times during the diurnal cycle. Animals injected just after light onset showed the greatest incorporation of label into opsin, while animals injected during the night period had the lowest levels of isotope incorporation. As determined by rocket immunoelectrophoresis, there was a 13-fold decline in specific activity in animals injected during the late night hours in comparison with animals injected just after light onset. In contrast, rod outer segment rhodopsin-specific activity did not vary as greatly. Animals subjected to a 12-hour light-12-hour dark diurnal cycle incorporated only twice the radiolabeled amino acids into their rhodopsin compared with animals injected and maintained in constant dark for 24 hours. Taken together, these experiments suggest that adult Rana pipiens accumulate opsin within their inner segments during the dark phase of the diurnal cycle and that alterations of this pool effect changes in inner segment opsin specific activity. Differences in outer segment rhodopsin specific activity are probably due to averaged metabolic differences between constant dark and light-dark animals.\nThis PDF is available to Subscribers Only", "domain": "chemistry", "round": 3} +{"url": "https://theone.ru/auto/B00AKYP15A.html", "date": "2019-03-22T02:21:51Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-13/segments/1552912202589.68/warc/CC-MAIN-20190322014319-20190322040319-00018.warc.gz", "language_score": 0.7804599404335022, "token_count": 277, "dump": "CC-MAIN-2019-13", "global_id": "webtext-fineweb__CC-MAIN-2019-13__0__86135320", "lang": "en", "text": "Genuine Toyota Fluid 00475-1BF03 Brake Fluid - 12 oz.\nThe exact Original Equipment Manufacturer fluid that your vehicle came with; developed for brake and hydraulic clutch systems to reduce vapor lock by providing a higher boiling point\nSuperior metal component protection\nHelps prevent corrosion and leakage\nFor use in the master brake cylinder\nMeets/exceeds DOT 3 performance specifications\nBrake fluid maintains a high boiling point even under the most severe operating conditions, offers superior protection against metal corrosion and does not form harmful sedimentation. Toyota products are crafted to the same high standards as your Toyota vehicle. They are developed through the performance and durability testing of professional community.\nToyota Genuine Fluid 00272SLLC2 Long Life Coolant - 1 Gallon\nToyota Genuine Fluid 00718ATF00 Dexron III Transmission Fluid - 1 Quart\nGenuine Toyota Lexus Automatic Transmission Fluid 1QT WS ATF World Standard (4 Pack)\nGenuine Toyota Lexus Automatic Transmission Fluid 1QT WS ATF World Standard\nGenuine Toyota (00279-000T4-01) Automatic Transmission Fluid\n05-08 Suzuki Forenza Master Power Window Switch Left Driver LH OEM 14J841\nOES Genuine EGR Vacuum Controller W0133-1720679-OES", "domain": "chemistry", "round": 3} +{"url": "https://www.furon.com/accessories/pressure-regulators/uprm-pressure-regulators/furon-uprm-pressure-regulator-pneumatic", "date": "2023-11-28T11:02:49Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679099281.67/warc/CC-MAIN-20231128083443-20231128113443-00553.warc.gz", "language_score": 0.7690002918243408, "token_count": 332, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__72522856", "lang": "en", "text": "Furon® UPRM Pressure Regulator - Pneumatic\nHigh Purity Pressure Regulator\nFuron UPRM Pneumatic Pressure Regulators from Saint-Gobain are engineered to accurately maintain predetermined output pressures in fluid lines utilizing a pneumatic actuator. Constructed from 100% high-purity PFA and PTFE wetted parts, these pressure regulators are ideal for ultra-pure, harsh or aggressive chemicals commonly used in semiconductor manufacturing. A modified PTFE isolation diaphragm protects the actuator components from the process media, eliminating the possibility of contamination from metal elements.\n|Max. Liquid Temperature °F (°C)||194 (90)|\n|Max. Inlet Liquid Pressure Psig (Bar)||90 (6.2)|\n|Flow Path||2 Way|\nFeatures & Benefits\n- Handles fluid temperatures up to 194°F (90°C)\n- All fluoropolymer wetted surfaces\n- Non-metallic external surfaces\n- Integral leak port detection\n- Panel mount feature standard\nFuron® UPRM Pneumatic Pressure Regulators from Saint-Gobain feature PFA and PTFE wetted parts and feature a PTFE isolation diaphragm.\nThe Furon UPRM and UPRP Pressure Regulators both maintain the downstream output flow pressures and are installed at the start of a system or pressure\nFeaturing Furon® products, Saint-Gobain’s newly updated High-Purity Fluid Handing Solutions for Microelectronics catalog that gives an overview of the", "domain": "chemistry", "round": 3} +{"url": "https://extremehomecareovencleaning.co.uk/appliance-cleaning.php", "date": "2021-04-23T07:15:14Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-17/segments/1618039568689.89/warc/CC-MAIN-20210423070953-20210423100953-00243.warc.gz", "language_score": 0.8945329189300537, "token_count": 304, "dump": "CC-MAIN-2021-17", "global_id": "webtext-fineweb__CC-MAIN-2021-17__0__36729053", "lang": "en", "text": "Is your washing machine and/or dishwasher performing badly?\nIt could be due to a build-up of limescale.\nDoes your washing machine and/or dishwasher smell?\nYou could have a build up of detergent residue and odour causing bacteria.\nNowadays more people are using non-biological washing powders and liquids and washing at lower temperatures. This can lead to a build-up in limescale and detergent residue.\nAccording to some estimates, the average washing machine load contains up to 100million E.coli. You may think these are killed off during the wash, but because the temperature inside some washing machines never goes above 30°C, bacteria survives and spreads from one fabric to another.\nOur Extreme Homecare Technician will clean and descale your washing machine and/or dishwasher removing limescale, detergent and grease build-up and restore them to top working condition.\nProtect your dishwasher and washing machine from a harmful build-up of limescale and detergent with an Extreme Homecare Appliance Clean which:\n- Removes limescale build-up from internal parts\n- Eliminates detergent build-up\n- Helps kill odour-causing bacteria\n- Hygienically cleans all internal parts\n- Maximises the efficiency of your appliance and helps reduce energy bills\n- May reduce the quantity of detergent required by up to a third\n- Prolongs the life of your appliance", "domain": "chemistry", "round": 3} +{"url": "http://onlinelibrary.wiley.com/doi/10.1110/ps.04823504/references", "date": "2017-01-24T12:40:33Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-04/segments/1484560284405.58/warc/CC-MAIN-20170116095124-00387-ip-10-171-10-70.ec2.internal.warc.gz", "language_score": 0.683224081993103, "token_count": 1875, "dump": "CC-MAIN-2017-04", "global_id": "webtext-fineweb__CC-MAIN-2017-04__0__208798504", "lang": "en", "text": "Insulin amyloid fibrillation at above 100°C: New insights into protein folding under extreme temperatures\nVersion of Record online: 1 JAN 2009\nCopyright © 2004 The Protein Society\nVolume 13, Issue 9, pages 2429–2436, September 2004\nHow to Cite\nArora, A., Ha, C. and Park, C. B. (2004), Insulin amyloid fibrillation at above 100°C: New insights into protein folding under extreme temperatures. Protein Science, 13: 2429–2436. doi: 10.1110/ps.04823504\n- Issue online: 1 JAN 2009\n- Version of Record online: 1 JAN 2009\n- Manuscript Accepted: 12 JUN 2004\n- Manuscript Revised: 4 JUN 2004\n- Manuscript Received: 19 APR 2004\n- 2003. Partially folded intermediates in insulin fibrillation. Biochemistry 42: 11404–11416. , , , , and\n- 1988. The structure of 2Zn pig insulin crystals at 1.5Å resolution. Philos. Trans. R. Soc. Lond. 319: 369–456. , , , , , and\n- 2000. Formation of insulin amyloid fibrils followed by FTIR simultaneously with CD and electron microscopy. Protein Sci. 9: 1960–1967. , , , , and\n- 1997a. Toward understanding insulin fibrillation. J. Pharm. Sci. 86: 517–525. , , , , and\n- 1997b. A model of insulin fibrils derived from the X-ray crystal structure of a monomeric insulin (despentapeptide insulin). Proteins 27: 507–516. , , , , and\n- 1981. The logistic curve for the fitting of sigmoidal data. Physiol. Chem. Phys. 13: 221–230. , , and\n- 1989. Low-temperature unfolding of a mutant of phage T4 lysozyme. 2. Kinetic investigations. Biochemistry 26: 691–699. , , and\n- 2003. Aggregation of bovine insulin probed by DSC/PPC calorimetry and FTIR spectroscopy. Biochemistry 42: 11347–11355. , , , and\n- 2001. Molecular dynamics simulations of wild-type and point mutation human prion protein at normal and elevated temperature. J. Mol. Graph. Modell. 20: 145–154. , , and\n- 2002. Protein stability. In Structure and mechanism in protein science, pp. 508–538. W.H. Freeman and Company, New York.\n- 1991. Production of recombinant human transthyretin with biological activities toward the understanding of the molecular basis of familial amyloidotic polyneuropathy (FAP). Biochemistry 30: 2415–2421. , , , , , , , and\n- 1999. Heat-induced denaturation and aggregation of β-lactoglobulin: Kinetics of formation of hydrophobic and disulphide-linked aggregates. Int. J. Food Sci. Tech. 34: 467–476. and\n- 1997. Models of amyloid seeding in Alzheimer's disease and scrapie: Mechanistic truths and physiological consequences of the time-dependent solubility of amyloid proteins. Annu. Rev. Biochem. 66: 385–407. and\n- 2002. Identifying protein folding cores from the evolution of flexible regions during unfolding. J. Mol. Graph. Modell. 21: 195–207. , , , and\n- 2000. Towards the ecology of hyperthermophiles: biotopes, new isolation strategies and novel metabolic properties. FEMS Microbiol. Rev. 24: 615–623. , , and\n- 1996. Thermal denaturation of an all β-sheet protein—Identification of a stable partially structured intermediate at high temperature. Int. J. Biol. Macromol. 18: 303–306. , , , , , and\n- 2002. The protofilament structure of insulin amyloid fibrils. Proc. Natl. Acad. Sci. 99: 9196–9201. , , , , , and\n- 2000. Review: Amyloidogenesis—Unquestioned answers and unanswered questions. J. Struct. Biol. 130: 99–108.\n- 1998. Temperature dependence of amyloid β-protein fibrillation. Proc. Natl. Acad. Sci. 95: 12277–12282. , , , and\n- 1996. The acid-mediated denaturation pathway of transthyretin yields a conformational intermediate that can self-assemble into amyloid. Biochemistry 35: 6470–6482. , , and\n- 1993. Thioflavin T interaction with synthetic Alzheimer's disease β-amyloid peptides: Detection of amyloid aggregation in solution. Protein Sci. 2: 404–410.\n- 1995. Energetics of protein structure. Adv. Protein Chem. 47: 307–425. and\n- 2000. Review: Modulating factors in amyloid-β fibril formation. J. Struct. Biol. 130: 259–270. , , , and\n- 2003. Temperature-induced dissociation of protein aggregates: accessing the denatured state. Biochemistry 42: 14234–14241. and\n- 1994. Equilibrium intermediates in the denaturation of human insulin and two monomeric insulin analogs. Biochemistry 33: 1116–1124. and\n- 2002. Peptide aggregation in neurodegenerative disease. Annu. Rev. Biomed. Eng. 4: 155–174.\n- 1999. Kinetic analysis of amyloid fibril formation. Methods Enzymol. 309: 305–318. and\n- 2000. Characterization of the oligomeric states of insulin in self-assembly and amyloid fibril formation by mass spectrometry. Biophys. J. 79: 1053–1065. , , , , , and\n- 2001. Effects of environmental factors on the kinetics of insulin fibril formation: Elucidation of the molecular mechanism. Biochemistry 40: 6036–6046. , , , , , , , and\n- 1995. Negative activation enthalpies in the kinetics of protein folding. Proc. Natl. Acad. Sci. 92: 8926–8929. , , and\n- 1987. An introduction to prion biology and diseases. In Prion biology and diseases (ed. S.B.Prusiner), pp. 1–66. Cold Spring Laboratory, Cold Spring Harbor, NY.\n- 1992. The molten globule state. In Protein folding (ed. T.E.Creighton), pp. 243–300. W.H. Freeman and Company, New York.\n- 2003. A mechanism of macroscopic (amorphous) aggregation of the tobacco mosaic virus coat protein. Int. J. Biochem. Cell Biol. 35: 1452–1460. , , , , , and\n- 1998. Novel evolutionary histories and adaptive features of proteins from hyperthermophiles. Curr. Opin. Biotechnol. 9: 288–291. and\n- 2000. Amyloid fibrillogenesis: Themes and variations. Curr. Opin. Struct. Biol. 10: 60–68. and\n- 1994. Creutzfeld-Jakob disease: Recommendations for infection control. Am. J. Infect. Control 22: 312–318.\n- 1999. Extremophiles and their adaptation to hot environments. FEBS Lett. 452: 22–25.\n- 1996. The nanometer-scale structure of amyloid-β visualized by atomic force microscopy. J. Protein Chem. 15: 193–203. , , , , , , , and\n- 1998. The effects of temperature on the kinetics and stability of mesophilic and thermophilic 3-phosphoglycerate kinases. Biochem. J. 330: 1087–1095. and\n- 2001. Pesticides directly accelerate the rate of α-synuclein fibril formation: A possible factor in Parkinson's disease. FEBS Lett. 500: 105–108. , , and\n- 1996. Thermozymes: Identifying molecular determinants of protein structural and functional stability. Trends Biotechnol. 14: 183–190. and\n- 1996. Thermozymes. Biotechnol. Annu. Rev. 2: 1–83. , , and\n- 2002. Insulin at pH 2: Structural analysis of the conditions promoting insulin fiber formation. J. Mol. Biol. 318: 479–490. , , , , , , and", "domain": "chemistry", "round": 3} +{"url": "https://uen.pressbooks.pub/urj22v2/chapter/optimizing-protocols-for-rna-isolation-from-fixed-tissue/", "date": "2024-02-23T22:50:22Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707947474470.37/warc/CC-MAIN-20240223221041-20240224011041-00393.warc.gz", "language_score": 0.9437053203582764, "token_count": 478, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__119851031", "lang": "en", "text": "School of Dentistry\nFaculty Mentor: Melodie Weller (Dentistry, University of Utah)\nDetection of pathogens in environmental specimens is challenging due to the rapid degradation of nucleic acids based on preservation techniques used. A study was designed to evaluate two protocols for specimen preparation for optimized preservation and integrity of cellular and viral RNA: 1) formalin-fixed paraffin embedded (FFPE) sample processing and 2) optimal cutting temperature (OCT) embedding compound for fixed and frozen tissue specimens. Soybeans in stage 1 of germination were fixed with 10% formalin for 24 to 48 hours prior to embedding in either FFPE or OCT. RNA was then isolated from 5um thick slices using a Qiagen RNeasy FFPE Kit. RNA quantity was measured with QubitTM RNA High Sensitivity (HS) Assay Kit and RNA integrity was assessed using QubitTM RNA IQ Assay Kit.\nThe objective of this study was to determine the optimal protocol for isolation of RNA from environmental samples. This study focused on the FFPE and OCT protocols. Each protocol had its own timeframe, challenges, and implications. FFPE required longer sample processing time, more reagents for step-wise tissue dehydration, and instrumentation to facilitate embedding specimens into hot paraffin wax. The OCT protocol required less time and reagents to process samples. FFPE and OCT protocols for RNA isolation were used to determine the optimal RNA concentrations and integrity of 24hr and 48hr fixed tissues.\nIn conclusion, the RNA concentrations for both FFPE and OCT were not significantly different (ns, p-value >0.05). Therefore, there was not a statistically significant difference between the embedding processes evaluated or for formalin fixation of 24 or 48 hours. Furthermore, no significant difference was observed between RIQ score between FFPE and OCT methods or for fixation of 24 or 48 hours. Both FFPE and OCT samples rendered a similar RNA concentration and RIQ score. The hours invested in each tissue embedding protocol were significantly different. FFPE requires a total of 96 hours to process the tissues, while the OCT protocol only requires 2 hours to process the tissues. For the future, the aim is to compare the FFPE and OCT protocols and observe if RNA is retained in situ.", "domain": "chemistry", "round": 3} +{"url": "https://sst.semiconductor-digest.com/2005/04/centerbapril-2005-exclusive-feature-etch-bp-bplasma-etching-using-an-icp-etcher-b-center-h2/", "date": "2023-09-23T15:16:58Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233506481.17/warc/CC-MAIN-20230923130827-20230923160827-00561.warc.gz", "language_score": 0.9027702808380127, "token_count": 366, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__29407805", "lang": "en", "text": "By Georgy K. Vinogradov, Masaharu Takeda, FOI Corp., Kanagawa, Japan\nHighly selective SiO2 etching plasma processes increasingly are required in manufacturing of ultralarge scale integrated circuits, where deep etching of silicon oxide (oxide) layers involves fluorocarbon deposition. Such processes, based on unsaturated fluorocarbons like c-C4F8, C4F6 or C5F8, have been developed and widely used in recent years. Because of special mechanisms of plasma chemical etching [1-3], it is difficult to etch high aspect ratio contact (HARC) holes without etch-stop or microloading effects under the conditions of high selectivity. In practice, thus, there is only one type of 200/300mm plasma etcher for highly selective SiO2 etch, especially for HARC holes: narrow-gap parallel-plate capacitive. This article presents a different approach to address the requirements of these processes.\nCapacitive reactive ion etching (RIE) tools (also known as two-frequency capacitive plasma sources) have had a long, useful life in the industry. For more than three decades of semiconductor plasma processing, there were no competitive tools around for one basic reason: a requirement of low gas residence time. Since a wafer size determines two dimensions (x-y), the only way to provide low gas residence time is to decrease the discharge volume by shrinking the space or discharge gap (z) over a wafer stage. Yet another reason is that a parallel plate configuration is expedient for generating uniform RF bias sheath, crucial for a deep oxide etch.\nJulie MacShane, Managing Editor, SST at email: [email protected].", "domain": "chemistry", "round": 3} +{"url": "https://oleochem.com/about/who-we-are/", "date": "2023-03-26T14:43:50Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-14/segments/1679296945473.69/warc/CC-MAIN-20230326142035-20230326172035-00017.warc.gz", "language_score": 0.949352502822876, "token_count": 345, "dump": "CC-MAIN-2023-14", "global_id": "webtext-fineweb__CC-MAIN-2023-14__0__111471483", "lang": "en", "text": "Oleochem was formed in 2004, to join as an independent member of the well-established Oleochem group of companies, which began providing services to the oil & gas industry in 1992. Oleochem’s unique name comes from Oleum; the Latin word meaning oil and chemistry. The group of companies have now all become one entity, operating from its main base in Aberdeen, specialising in providing turn-key solutions world-wide. Oleochem is managed by hands-on, experienced production chemists who possess a real in-depth understanding of client’s requirements and the industry as a whole.\nProviding a fully integrated range of services, covering a wide spectrum within the upstream production and downstream process industries, Oleochem’s unique approach provides our clients with a turn-key solution to their new build, conversion or upgrade projects. Through the years Oleochem have gained world leading knowledge and an excellent reputation in the supply of consultancy, production chemists, laboratory equipment and laboratory modules.\nOleochem’s in-depth laboratory experience, is of particular benefit to operators of new processing plants or offshore installations (such as an FPSO). The company can draw on its extensive track record in lab commissioning contracts, to design the facilities, supplying of equipment, providing the personnel for start-up and train local staff. An example of such a case, was seen when Oleochem’s assistance was requested in a new onshore processing terminal, to be based on the Vietnamese coast. Oleochem provided services including, new equipment recommendations, design and set-up of the laboratory, provision of experienced laboratory chemists and the training (followed by competency assessment) of local staff.", "domain": "chemistry", "round": 3} +{"url": "https://appel.weill.cornell.edu/publications/formation-intermediate-conductance-calcium-activated-potassium-channels-interaction", "date": "2023-12-01T16:36:12Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100290.24/warc/CC-MAIN-20231201151933-20231201181933-00015.warc.gz", "language_score": 0.8371871709823608, "token_count": 404, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__115831671", "lang": "en", "text": "|Title||Formation of intermediate-conductance calcium-activated potassium channels by interaction of Slack and Slo subunits.|\n|Publication Type||Journal Article|\n|Year of Publication||1998|\n|Authors||Joiner WJ, Tang MD, Wang LY, Dworetzky SI, Boissard CG, Gan L, Gribkoff VK, Kaczmarek LK|\n|Date Published||1998 Oct|\n|Keywords||Amino Acid Sequence, Animals, Caenorhabditis elegans, Caenorhabditis elegans Proteins, Electric Conductivity, Intermediate-Conductance Calcium-Activated Potassium Channels, Isomerism, Large-Conductance Calcium-Activated Potassium Channels, Molecular Sequence Data, Nerve Tissue Proteins, Potassium Channels, Potassium Channels, Calcium-Activated|\nLarge-conductance calcium-activated potassium channels (maxi-K channels) have an essential role in the control of excitability and secretion. Only one gene Slo is known to encode maxi-K channels, which are sensitive to both membrane potential and intracellular calcium. We have isolated a potassium channel gene called Slack that is abundantly expressed in the nervous system. Slack channels rectify outwardly with a unitary conductance of about 25-65 pS and are inhibited by intracellular calcium. However, when Slack is co-expressed with Slo, channels with pharmacological properties and single-channel conductances that do not match either Slack or Slo are formed. The Slack/Slo channels have intermediate conductances of about 60-180 pS and are activated by cytoplasmic calcium. Our findings indicate that some intermediate-conductance channels in the nervous system may result from an interaction between Slack and Slo channel subunits.\n|Alternate Journal||Nat. Neurosci.|", "domain": "chemistry", "round": 3} +{"url": "http://publikationen.ub.uni-frankfurt.de/solrsearch/index/search/searchtype/authorsearch/author/%22Michael+Fischer%22/start/0/rows/10/subjectfq/EET", "date": "2015-05-23T10:38:28Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2015-22/segments/1432207927458.37/warc/CC-MAIN-20150521113207-00158-ip-10-180-206-219.ec2.internal.warc.gz", "language_score": 0.8843802809715271, "token_count": 513, "dump": "CC-MAIN-2015-22", "global_id": "webtext-fineweb__CC-MAIN-2015-22__0__42625621", "lang": "en", "text": "- EET (1) (remove)\n- Soluble epoxide hydrolase limits mechanical hyperalgesia during inflammation (2011)\n- Background Cytochrome-P450 (CYP450) epoxygenases metabolise arachidonic acid (AA) into four different biologically active epoxyeicosatrienoic acid (EET) regioisomers. Three of the EETs (i.e., 8,9-, 11,12- and 14,15-EET) are rapidly hydrolysed by the enzyme soluble epoxide hydrolase (sEH). Here, we investigated the role of sEH in nociceptive processing during peripheral inflammation. Results In dorsal root ganglia (DRG), we found that sEH is expressed in medium and large diameter neurofilament 200-positive neurons. Isolated DRG-neurons from sEH-/- mice showed higher EET and lower DHET levels. Upon AA stimulation, the largest changes in EET levels occurred in culture media, indicating both that cell associated EET concentrations quickly reach saturation and EET-hydrolyzing activity mostly effects extracellular EET signaling. In vivo, DRGs from sEH-deficient mice exhibited elevated 8,9-, 11,12- and 14,15-EET-levels. Interestingly, EET levels did not increase at the site of zymosan-induced inflammation. Cellular imaging experiments revealed direct calcium flux responses to 8,9-EET in a subpopulation of nociceptors. In addition, 8,9-EET sensitized AITC-induced calcium increases in DRG neurons and AITC-induced calcitonin gene related peptide (CGRP) release from sciatic nerve axons, indicating that 8,9-EET sensitizes TRPA1-expressing neurons, which are known to contribute to mechanical hyperalgesia. Supporting this, sEH-/- mice showed increased nociceptive responses to mechanical stimulation during zymosan-induced inflammation and 8,9-EET injection reduced mechanical thresholds in naive mice. Conclusion Our results show that the sEH can regulate mechanical hyperalgesia during inflammation by inactivating 8,9-EET, which sensitizes TRPA1-expressing nociceptors. Therefore we suggest that influencing the CYP450 pathway, which is actually highly considered to treat cardiovascular diseases, may cause pain side effects.", "domain": "chemistry", "round": 3} +{"url": "https://jmmm.material.chula.ac.th/index.php/jmmm/article/view/1267", "date": "2023-05-29T20:07:42Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-23/segments/1685224644907.31/warc/CC-MAIN-20230529173312-20230529203312-00158.warc.gz", "language_score": 0.7588297724723816, "token_count": 3810, "dump": "CC-MAIN-2023-23", "global_id": "webtext-fineweb__CC-MAIN-2023-23__0__112603846", "lang": "en", "text": "Sm3+ doped Mn-Zn mixed ferrites: Synthesis and characterization\nKeywords:Ferrites, Rare Earth, XRD, SEM, VSM\nPure and Samarium (Sm3+) doped Mn-Zn ferrites were synthesized using Co-precipitation method. The Sm3+ concentration varied from 0.1% to 0.3%. This was added to the solution during the synthesis of Mn-Zn ferrites (Mn0.5Zn0.5Fe2O4) at room temperature. The precipitate so obtained was annealed at 200℃ for 4 h and then crushed to powder. The powdered material was subjected to structural, morphological, compositional, optical and magnetic characterization. XRD shows cubic spinal structure with crystallite size of the order of 6 nm. TEM and SEM images show spherical particles are in good agreement with XRD data. EDAX indicates stoichiometry of elements present in material. FTIR shows various functional groups and doped samarium. VSM for pure Mn:Zn ferrite show hysteresis with high magnetization, coercivity and low remanence. All the magnetic parameters decrease on 0.1% Sm3+ doping. These parameters get increased, compared to values at 0.1% doping, on increasing Sm3+ doping to 0.2%. On further increasing Sm3+ doping to 0.3%, the magnetic parameters show insignificant changes. VSM shows that Sm3+ affects magnetic properties significantly only at lower doping concentrations. These changes are due to Sm3+ substitution at tetrahedral and octahedral positions. The ionic radii mismatch in between Samarium and iron influence the magnetic parameters of Mn0.5Zn0.5Fe2O4.\nM. Sugimoto, “The past, present and future of ferrites,” Journal of American Chemical Society, vol. 82, pp. 269-280, 1999.\nA. H. Lu, E. L. Salabas, and F. Schth, “Magnetic nanoparticles: Synthesis, protection, fictionalization, and application,” Angewandte Chemie International Edition, vol. 46, no. 8, pp. 1222-1244, 2007.\nD. Stoppels, “Developments in soft magnetic power ferrites”, Journal of Magnetism and Magnetic Materials, vol.160, pp. 323-328, 1996.\nP. Hu, H. B. Yang, D. A. Pan, H. Wang, J. J. Tian, S. G. Zhang, X. F. Wang, and A. A. Volinsky,” Heat treatment effects on microstructure and magnetic properties of Mn–Zn ferrite powders,” Journal of Magnetism and Magnetic Materials, vol. 322, pp.173-177, 2010.\nU. Ghazanfar, S. A. Siddiqi, and G. Abbas, “Structural analysis of the Mn–Zn ferrites using XRD technique,” Material Science and Engineering B, vol. 118, pp.84-86, 2005.\nG. Ott, J. Wrba, and R. Lucke, “Recent Developments of Mn-Zn Ferrites for high permeability applications,” Journal of Magnetism and Magnetic Materials, vol. 254-255, pp. 535-537, 2003.\nH. Waqus, and A. H. Quresghi, “Influence of pH on nano sized Mn–Zn ferrite synthesized by sol–gel auto combustion process,” Journal of Thermal Analysis and Calorimetry, vol. 98, no. 2, pp. 355-360, 2009.\nA. D. P. Rao, B. Ramesh, P. R. M. Rao, and S. B. Raju, “X-ray diffraction studies of Sn/Nb substituted Mn-Zn ferrites,” IL Nuovo Cimento D, vol. 20, no. 2, p. 9, 1998.\nH. N. Ji, Z. W. Lan, Z. Yu, Y. J. Zhi, and Z. Liu, IEEE Applied Superior Electronic Devices, pp. 25, 2009.\nV. Sepelak, P. Heitjans, and K. D. Becker, “Nanoscale spinel ferrites prepared by mechano-chemical route,” Journal of Thermal Analysis and Calorimetry, vol. 90, no. 1, pp. 93-97, 2007.\nK. Q. Jiang, K. K. Li, C. H. Peng, and Y. Zhu, “Effect of multi-additives on the microstructure and magnetic properties of high permeability Mn-Zn ferrite,” Journal of Alloys and Compounds, vol. 541, pp. 472-476, 2012.\nH. Anwar, and A. Maqsood “Comparison of structural and electrical properties of Co2+ doped Mn-Zn soft nano ferrites prepared via co-precipitation and hydrothermal methods,” Material Research Bulletin, vol. 49, pp. 426-433, 2014.\nH. Bayrakdar, O. Yalçın, S. Vural, and K. Esmer, “Effect of different doping on the structural, morphological and magnetic properties for Cu doped nanoscale spinel type ferrites,” Journal of Magnetism and Magnetic Materials, vol. 343, pp. 86-91, 2013.\nM. Gu, and G. Q. Liu. “Effects of MoO3 and TiO2 additions on the magnetic properties of manganese-zinc power ferrites,” Journal of Alloys and Compounds, vol. 475, pp. 356-360, 2009.\nM. A. Gabal, A. M. Abdel-Daiem, Y. M. Al Angari, and I. M. Ismail, “Influence of Al-substitution on structural, electrical and magnetic properties of Mn-Zn ferrites nanopowders prepared via the sol-gel auto-combustion method,” Polyhedron, vol. 57, pp. 105-111, 2013.\nH. N. Ji, Z. W. Lan, Z. Yu, K. Sun, and L. Z. Li, “Influence of Sn-substitution on temperature dependence and magnetic dis-accommodation of manganese-zinc ferrites,” Journal of Magnetism and Magnetic Materials, vol. 321, no. 14, pp. 2121-2124, 2009.\nJ. Bifa, T. Changan, Z. Quanzheng, J. Dongdong, Y. Jie, X. Jinsong, and S. Jingyu, “Magnetic properties of samarium and gadolinium co-doping Mn-Zn ferrites obtained by sol-gel auto-combustion method,” Journal of Rare Earths, vol. 34, no. 10, pp. 1017-1023, 2016.\nA. B. Mugutkara, S. K. Gore, U. B. Tumberphale, V. K. V. Jadhav, R. S. Mane, S. M. Patange, S. E. Shirsath, and S. S. Jadhav, “Role of composition and grain size in controlling the structure sensitive magnetic properties of Sm3+ substituted nanocrystalline Co-Zn ferrites,” Journal of Rare Earths, vol. 38, no. 10, pp. 1069-1075, 2020.\nQ. K. Xing, Z. J. Peng, C. B. Wang, and X. L. Fu, “Doping effect of Y3+ ions on the microstructural and electromagnetic properties of Mn-Zn ferrites,” Physica B: Condensed Matter, vol. 407, no. 3, pp. 388-392, 2012.\nN. Lwin, M. N. A. Fauzi, S. Sreekantan, and R. Othman, “Physical and electromagnetic properties of nanosized Gd substituted Mg-Mn ferrites by solution combustion method,” Physica B: Condensed Matter, vol. 461, no. 15, pp. 134-139, 2015.\nS. E. Jacobo, S. Duhalde, and H. R. Bertorello, “Rare earth influence on the structural and magnetic properties of Ni-Zn ferrites,” Journal of Magnetism and Magnetic Materials, vol. 272-276, pp. 2253-2254, 2004.\nS. Tapdiya, S. Singh, S. Kulshrestha, and A. K. Shrivastava, “Micro structural analysis and magnetic characteristics of rare earth substituted cobalt Ferrite,” AIP Conference Proceedings, vol. 1953, p. 120025, 2018.\nA. B. Kadam, V. K. Mande, S. B. Kadam, R. H. Kadam, S. E. Shirsath, and R. B. Borade, “Influence of gadolinium (Gd3+) ion substitution on structural, magnetic and electrical properties of cobalt ferrites,” Journal of Alloys and Compounds, vol. 840, p.155669, 2020.\nV. More, R. B. Borade, K. Desai, V. K. Barote, S. S. Kadam, V. S. Shinde, D. R. Kulkarn, R. H. Kadam, and S. T. Alone “Site occupancy, surface morphology and mechanical properties of Ce3+ Added Ni–Mn–Zn Ferrite Nano crystals Synthesized Via Sol–Gel Route” NANO: Brief Reports and Reviews, vol. 16, no. 5, p. 2150059, 2021.\nR. H. Kadam, R. B. Borade, M. L. Mane, D. R. Mane, K. M. Batoo, and S. E. Shirsath, “Structural, mechanical, dielectric properties and magnetic interactions in Dy3+-substituted Co–Cu–Zn nanoferrites,” RSC Advances, vol. 10, no. 47, p. 27911, 2020.\nM. V. Chaudhari, S. E. Shirsath, A. B. Kadam, R. H. Kadam, S. B. Shelke, and D. R. Mane, “Site occupancies of Co–Mg–Cr–Fe ions and their impact on the properties of Co0.5Mg0.5CrxFe2-xO4,” Journal of Alloy and Compounds, vol. 552, no. 5, pp. 443-450, 2013.\nV. J. Angadi, B. Rudraswamy, E. Melagiriyappa, Y. Shivaraj, and S. Matteppanavar, “Effect of Sm3+ substitution on structural and magnetic investigation of nano sized Mn–Sm–Zn ferrites,” Indian Journal of Physics, vol. 90, no. 8, pp. 881-885, 2016.\nM. A. Iqbal, M. Islamn, I. Ali, H. M. Khan, G. Mustafa, and I. Ali, “Study of electrical transport properties of Eu3+ substituted Mn-Zn-ferrites synthesized by co-precipitation technique,” Ceramics International, vol. 39, pp. 1539-1545, 2013.\nA. B. Mugutkar, S. K. Gore, R. S. Mane, K. M. Batoo, S. F. Adil, and S. S. Jadhav, “Magneto-structural behaviour of Gd doped nanocrystalline Co-Zn ferrites governed by domain wall movement and spin rotations,” Ceremic International, 2018.\nR. A. Pawar, S. M. Patange, A. R. Shitre, S. K. Gore, S. S. Jadhav, and S. E. Shirsath, “Crystal chemistry and single-phase synthesis of Gd3+ substituted Co–Zn ferrite nanoparticles forenhanced magnetic properties,” RSC Advances., vol 8, p. 25258, 2018.\nA. Shrivastava, and A. K. Shrivastava, “Improvement in properties of Mn-Zn ferrite nanoparticles by rare earth doping,” Journal of Nano and Electronic physics, vol. 13, no. 2, p. 02002, 2021.\nR. P. Pant, M. Arora, B. Kaur, V. Kumar, and A. Kumar, “Finite size effect on Gd3+ doped CoGdxFe2-xO4 (0.0 ≤ x ≤ 0.5)particles,” Journal of Magnetism and Magnetic Materials, vol. 322, no. 22, pp. 3688-3691, 2010.\nW. Lueangchaichaweng, B. Singh, D. Mandelli, W. A. Carvalho, S. Fiorilli, and P. P. Pescarmona, “High surface area, nano-structured boehmite and alumina catalysts: Synthesis and application in the sustainable epoxidation of alkenes,” Applied Catalysis A: General, vol. 571, pp. 180-187, 2019.\nU. N. Trivedi, K. H. Jani, K. B. Modi, and H. H. Joshi, “Study of cation distribution in lithium doped nickel ferrite,” Journal of Material Science Letters, vol. 19, pp. 1271-1273, 2000.\nR. M. Mohamed, M. M. Rashad, F. A. Haraz, and W. Sigmund, “Structure and magnetic properties of nano-crystalline cobalt ferrite powders synthesized using organic acid precursor method,” Journal of Magnetism and Magnetic Materials, vol. 322, no. 14, pp. 2058-2064, 2010\nA. B. Mugutkar, S. K. Gore, R. S. Mane, S. M. Patange, S. S. Jadhav, S. F. Shaikh, A. M. Al-Enizi, A. Nafady, B. M. Thamer, and M. Ubaidullah, “Structural modifications in Co–Zn nanoferrites by Gd substitution triggering to dielectric and gas sensing applications,” Journal of Alloys and Compounds, vol. 844, p. 156178, 2020.\nJ. Coates, “Interpretation of infrared spectra, a practical approach,” in Encyclopedia of Analytical Chemistry (Ed.), p. 10815, 2000.\nS. Thakur, S. C. Katyal, and M. Singh, “Structural and magnetic properties of nano nickel–zinc ferrite synthesized by reverse micelle technique,” Journal of Magnetism and Magnetic Materials, vol. 321, no. 1, pp. 1-7, 2009.\nL. R. Maxwell, and S. J. Pickart, “Magnetization in nickel ferrite-aluminates and nickel ferrite-Gallates,” Physical Review Journals Archive, vol. 92, p. 1120, 1953.\nE. C. Snelling, “Soft ferrites: Properties and applications,” in Handbook of Modern Ferromagnetic Materials, 2nd ed., Butterworths, London, 1969.\nJ. Azadmanjiri, and S. A. Seyyed Ebrahimi, “Influence of stoichiometry and calcination condition on the microstructure and phase constitution of NiFe2O4 powders prepared by sol‐gel autocombustion method,” Physica. Status Solidi (C), vol. 1, no. 12, pp. 3414-3417, 2004.\nB. Baruwati, R. K. Rana, and S. V. Manorama, “Further insights in the conductivity behavior of nano-crystalline NiFe2O4,” Journal of Applied Physics, vol. 101, p. 014302, 2007.\nHow to Cite\nCopyright (c) 2022 Journal of Metals, Materials and Minerals\nThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.\nAuthors who publish in this journal agree to the following terms:\n- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.\n- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.", "domain": "chemistry", "round": 3} +{"url": "https://m.scirp.org/papers/8476", "date": "2020-02-17T12:33:19Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-10/segments/1581875142323.84/warc/CC-MAIN-20200217115308-20200217145308-00224.warc.gz", "language_score": 0.6965535283088684, "token_count": 1490, "dump": "CC-MAIN-2020-10", "global_id": "webtext-fineweb__CC-MAIN-2020-10__0__83910215", "lang": "en", "text": "ABSTRACT A series of Cu-Zn mixed ferrites with composition formula Cu1–xZnxFe2O4 is prepared by the double sintering ceramic technique. Thermoelectric power studies are performed over a temperature range of 300 to 800 k by a deferential method. The results showed a negative value for the Seebeck coefficient S for all samples, and all compositions exhibited an n-type semiconductors behavior in the measured range of temperature. The values of charge carrier concentration n and the Fermi energy were determined. The values of n were found to decrease as temperature increased, while Fermi energy directed to more negative values when Zn content is increased. On the basis of these results a mechanism for the conduction in Cu-Zn ferrites is suggested and the properties of the mention compounds were determined.\nCite this paper\nnullH. Dawoud, \"Thermoelectric Power of Cu-Zn Ferrites,\" Materials Sciences and Applications, Vol. 2 No. 11, 2011, pp. 1572-1577. doi: 10.4236/msa.2011.211210.\n P. K. Roy and J. Bera, “Enhancement of the Magnetic Properties of Ni-Cu-Zn Ferrites with the Substitution of a Small Fraction of Lanthanum for Iron,” Materials Re- search Bulletin, Vol. 42, No. 1, 2007, pp. 77-83.\n I. Z. Rahman and T. T. Ahemed, “A Study on Cu Substituted Chemically Processed Ni-Zn-Cu Ferrites,” Journal of Magnetism and Magnetic Materials, Vol. 290-291, 2005, pp. 1576-1579.\n D. Ravinder, “Thermoelectric Power and Electric Conductivity of Cd—Substituted Copper Ferrite,” Materials Letters, Vol. 44, No. 3-4, 2000, pp. 130-138.\n A. Gonchar, V. Andreev, L. Letyuk, A. Shishkanov and V. Maiorov, “Problems of Increasing of Thermostability of Highly Permeable Ni-Zn Ferrites and Relative Materials for Telecommunications,” Journal of Magnetism and\nMagnetic Materials, Vol. 254-255, 2003, pp. 544-546.\n M. C. Dimri, A. K. Verma, S. C. Kashyap, D. C. Dube and O. P. Thakur, “Structural, Dielectric and Magnetic Properties of NiCuZn Ferrite Grown by Citrate Precursor Method,” Materials Science and Engineering: B, Vol. 133, No. 1-3, 2006, pp. 42-48.\n P. A. Jadhav, R. S. Devan, Y. D. Kolekar and B. K. Chougule, “Structural, Electrical and Magnetic Charac- terizations of Ni-Cu-Zn Ferrite Synthesized by Citrate Precursor Method,” Journal of Physics and Chemistry of Solids, Vol. 70, No. 2, 2009, pp. 396-400.\n D. Ravinder, “Thermoelectric Power Studies of Zinc Sub- stituted Copper Ferrite,” Journal of Alloys and Com- pounds, Vol. 291, No. 1-2, 2000, pp. 208-214.\n K. V. Kumar and D. Ravinder, “Electrical Transport Properties of Erbium Substituted Ni-Zn Ferrite,” Inter- national Journal of Inorganic Materials, Vol. 3, No. 7, 2001, pp. 661-666. doi:10.1016/S1466-6049(01)00194-5\n S. A. Mazen, “Electrical Conductivity and Thermoelectric Power of Cu-Ti Ferrite,” Materials Chemistry and Physics, Vol. 56, No. 2, 1998, pp. 102-107.\n S. A. Mazen and A. Elfalaky, “Thermoelectric Power and Electrical Conductivity of Cu-Ti Ferrite,” Journal of Magnetism and Magnetic Materials, Vol. 195, No. 1, 1999, pp. 148-155. doi:10.1016/S0304-8853(98)00348-5\n B. L. Patil, S. R. Sawant and S. A. Patil, “Electrical and Magnetic Studies of Ba3Co2Fe23–12xMn12xO4 Hexafer- rites Type,” Physical State Solid (A), Vol. 133, No. 1-2, 1992, p. 147.\n P. V. Reddy, V. D. Reddy and D. Ravinder, “Ther- mopower Studies of Lithium-Zinc Mixed Ferrites,” Phy- sical State Solid (A), Vol. 127, No. 2, 1991, pp. 439-450.\n R. Manjula, V. R. K. Murthy and J. Sobhandri, “Electric Conduction in Ni-Zn Ferrite,” Journal of Applied Physics, Vol. 59, No. 5, 1986, p. 2929.\n H. A. Dawoud and S. K. K. Shaat, “Initial Permeability and Conductivity of Cu-Zn Ferrite,” Islamic University Journal, Vol. 14, No. 1, 2006, pp. 165-182.\n C. N. Chinnasamy, A. Narayanasamy, N. Ponpandian and K. Chottopdhyay, “Size Dependent Magnetic Behavior of Noncrystalline Spinel Ferrite,” Journal Materials Science and Engineering A, Vol. 304, 2001, p. 983.\n C. C. Wu, S. Krishnan and T. O. Mason, “Thermopower Composition Dependence in Ferrospinel,” Journal of Solid State Chemistry, Vol. 37, No. 2, 1981, pp. 144-150.\n H. M. Zaki and H. A. Dawoud, “Far Infrared Spectra for Cooper-Zinc Mixed Ferrite,” Physica B: Condensed Matter, Vol. 405, No. 21, 2010, p. 4479.\n F. J. Morin, “Charge Carrier and Mobility of Cu-Ti Fer- rite,” Physical Review, Vol. 93, 1970, p. 433.\n A. J. Bosman and C. Crevecoevr, “Electrical Conduction in Li-Doped CoO,” Journal of Physics and Chemistry of Solids, Vol. 30, No. 5, 1969, pp. 1151-1160.", "domain": "chemistry", "round": 3} +{"url": "https://www.enhcb.com/products/er17505-li-socl2-cylindrical-battery.html", "date": "2023-12-06T20:59:44Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100603.33/warc/CC-MAIN-20231206194439-20231206224439-00751.warc.gz", "language_score": 0.7814704775810242, "token_count": 594, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__218846339", "lang": "en", "text": "Primary Lithium Battery ER17505\n3600 mAh capacity\nWide Temperature Range Long Shelf Life\n3.6V Lithium-thionyl chloride [Li-SOCl2] A-size bobbin battery ER17505 Widely used in utilities，medical, stainless steel container, somke detector, water meter, electricity meter, gas meter, heat meter.\n|Place of Origin||Made in PRC|\n|Model Number||ER17505 / A size ER battery|\nHigh and Stable Voltage\nEnergy Density up to 590Wh/kg\nLong Shelf Life (less than 1% per year after 1 year of storage at +25℃)\nWide Operating Temperature (-55℃~+85℃)\n|Battery discharged at continuous current 1.7mA until the voltage reaches cut-off voltage 2.0V at ambient temperature 23±2℃|\n|Nominal Voltage||3.6 V|\n|Maximum Continuous Current||100mA|\n|Battery with minimum 50% rated capacity discharged at ambient temperature 23±2℃|\n|Maximum Pulse Discharge Current||250mA|\n|Battery with minimum 50% rated capacity discharged at max pulse for 3 seconds after 27seconds break. Ambient temperature 23±2℃|\nTemperature ≤ 30℃\nHumidity ≤ 75%RH\n|Operating Temperature||-55℃ to +85℃|\n|Battery Dimension||See drawing on page|\n|Max self-discharged rate at ambient temperature 23±2℃|\n|Shelf Life||10 years|\n|Ambient temperature 23±2℃|\nWe offer the nominal voltage of up to 3.6V, the working voltage varies with the load, generally between 3.3V ~ 3.6V.\nHigh Energy Density\nWe provide a specific energy density up to 510Wh/kg.\nWide Operating Temperature Range\nThe battery with strong adaptability to temperature can be in work between -55℃ ~ +85℃.\nStable Operating Voltage\nBattery voltage is very stable during work, more than 90% of the capacity could be output on a fixed high voltage platform.\nLong Shelf Life\nUnder the condition of normal temperature, theER17505 battery self-discharge rate of no more than 2% per year.\nBattery sealing using the fully sealed structure to reduce the leakage of the battery, make the battery can be stored at room temperature for more than 10 years.\nCardiac pacemaker, respirator, oxygenator, inspection devices, monitoring devices, infusion pump, etc.\nSmoke detectors, security alarms, seismometers, locking systems, monitoring systems, etc.\nRFID products, road toll transponder, IC cards, etc.", "domain": "chemistry", "round": 3} +{"url": "https://m.scirp.org/papers/6696", "date": "2022-09-29T08:48:40Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-40/segments/1664030335326.48/warc/CC-MAIN-20220929065206-20220929095206-00146.warc.gz", "language_score": 0.7220762968063354, "token_count": 1761, "dump": "CC-MAIN-2022-40", "global_id": "webtext-fineweb__CC-MAIN-2022-40__0__223826774", "lang": "en", "text": "M. Cozzolino, R. Tesser, M. D. Serio, P. D’Onofrio and E. Santacesaria, “Kinetics of the Oxidative Dehydrogenation (Odh) of Methanol to Formaldehyde by Supported Vanadium-Based Nanocatalysts,” Catalysis Today, Vol. 128, No. 3-4, August 2007, pp. 191-200.\n K. Lee, Y. Wang and G. Cao, “Dependence of Electrochemical Properties of Vanadium Oxide Films on Their nano- and Microstructures,” Journal Physics Chemical B, Vol. 109, No. 35, 2005, pp. 16700-16704. doi.org/10.1021/jp051686q\n Y. Wang, K. Takahashi, K. Lee and G. Cao, “Nanostructured Vanadium Oxide Electrodes for Enhanced Lithium-Ion Intercalation,” Advanced Functional Materials, Vol. 16, No. 9, 2006, pp. 1133-1144. doi.org/10.1002/adfm.200500662\n M. S. Whittingham, Y. N. Song, S. Lutta, P. Y. Zavalij and N. A. Chernova, “Some Transition Metal (Oxy) Phosphates and Vanadium Oxides for Lithium Batteries”, Journal of Materials Chemistry, Vol. 15, No. 33, April 2005, pp. 3362-3379. doi.org/10.1039/b501961c\n B. X. Li, Y. Xu, G. X. Rong, M. Jing and Y. Xie, “Vanadium Pentoxide Nanobelts and Nanorolls: from Controllable Synthesis to Investigation of Their Electrochemical Properties and Photocatalytic Activities,” Nanotechnology, Vol. 17, No. 10, April 2006, pp. 2560-2566.\n M. A. Gimenes, L. P. R. Profeti, T. A. F. Lassali, C. F. O. Graeff and H. P. Oliveira, “Synthesis Characterization, Electrochemical, and Spectroelectrochemical Studies of an N-Cetyl-Trimethylammonium Bromide/V2O5 Nanocomposite,” Langmuir, Vol. 17, No. 6, March 2001, pp. 1975-1982.\n F. Huguenin, M. Ferreira, V. Zucolotto, F. C. Nart, R. M. Torresi and O. N. Oliveira Jr., “Molecular-Level Manipulation of V2O5/Polyaniline Layer-by-Layer Films to Control Electrochromogenic and Electrochemical Properties,” Chemistry of Materials, Vol. 16, No. 11, April 2004, pp. 2293-2299.\n Y. Wang, K. Takahashi, K. Lee and G.Z. Cao, “Nanostructured Vanadium Oxide Electrodes for Enhanced Lithium-Ion Intercalation,” Advanced Functional Materials, Vol. 16, No. 9, June 2006, pp. 1133-1144.\n H. Qiao, X. J. Zhu, Z. Zheng, L. Liu and L. Z. Zhang, “Synthesis of V3O7?H2O Nanobelts as Cathode Materials for Lithium-Ion Batteries,” Electrochemistry Communications, Vol. 8, No. 1, January 2006, pp. 21-26.\n M. E. Spahr, P. Bitterli, R. Nesper, M. Muller, F. Krumeich and H. U. Nissen, “Redox Active Nanotubes of Vanadium Oxide,” Angewandte Chemie International Edition, Vol. 37, No. 9, 1998, pp. 1263-1265. doi.org/10.1002/(SICI)1521-3773(19980518)37:9<1263::AID-ANIE1263>3.0.CO;2-R\n J. Schoiswohl, S. Surnev, F. P. Netzer and G. Kresse, “Vanadium Oxide Nanostructure: from Zero to Three- Dimensional,” Journal Physical-Condemns Matter, Vol. 18, No. 4, 2006, pp. R1-R14. doi.org/10.1088/0953-8984/18/4/R01\n H. Y. Xu, H. Wang, Z. Q. Song, Y. W. Wang, H. Yan and M. Yoshimura, “Novel Chemical Method for Synthesis of LiV3O8 Nanorods as Cathode Materials for Lithium-Ion Batteries,” Electrochimica Acta, Vol. 49, No. 2, January 2004, pp. 349-353.\n F. Sediri and N. Gharbi, “From Crystalline V2O5 to Nanostructured Vanadium Oxides Using Aromatic Amines as Templates,” Journal of Physics and Chemistry of Solids, Vol. 68, No. 10, October 2007, pp.1821-1829.\n S. F. Shi, M. H. Cao, X. Y. He and H. M. Xie, “Surfactant-Assisted Hydrothermal Growth of Single-Crystalline Ultrahigh-Aspect-Ratio Vanadium Oxide Nanobelts,” Crystal Growth & Design, Vol. 7, No. 9, July 2007, pp. 1893-1897.\n S. Gao, Z. Chen, M. Wei, K. Wie and H. Zhou, “Single crystal Nanobelts of V3O7. H2O: A Lithium Intercalation host with a Large Capacity,” Electrochimica Acta, Vol. 54, No. 3, January 2009, pp. 1115-1118.\n J. -C. Valmalette and J. -R. Gavarri, “High efficiency Thermochromic VO2(R) Resulting from the Irreversible Transformation of VO2(B),” Materials Science and Engineering B, Vol. 54, No. 3, June 1998, pp. 168-173.\n C. Delmas, H. Cognac-Auradou, J. M. Cocciantelli, M. Ménétrier and J. P. Doumerc, “The LixV2O5 System: An overview of the Structure Modifications Induced by the Lithium Intercalation,” Solid State Ionics, Vol. 69, No. 3-4, August 1994, pp. 257-264.\n K. S. W. Sing, D. H. Everett, R. A. W. Haul, L. Moscou, R. A. Pierotti, J. Rouquerol and T. Siemieniewska, “Reporting Physisorption Data for Gas/Solid Systems with Special Reference to the Determination of Surface Area and Porosity,” Pure and Applied Chemistry, Vol. 57, No. 4, 1985, pp. 603-619.\n M. Toba, F. Mizukami, S. Niwa, T. Sano, K. Maeda, A. Annila and V. Komppa, “The Effect of Preparation Methods on the Properties of Zirconia/Silicas,” Journal of Molecular Catalysis, Vol. 94, No. 1, 1994, pp. 85-96.", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/rims3-antibody-ab67307.html", "date": "2020-09-24T19:05:28Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-40/segments/1600400219691.59/warc/CC-MAIN-20200924163714-20200924193714-00734.warc.gz", "language_score": 0.7551458477973938, "token_count": 593, "dump": "CC-MAIN-2020-40", "global_id": "webtext-fineweb__CC-MAIN-2020-40__0__201069992", "lang": "en", "text": "Key features and details\n- Rabbit polyclonal to RIMS3\n- Suitable for: WB, ICC/IF, IHC-P\n- Reacts with: Mouse, Rat, Human\n- Isotype: IgG\nProduct nameAnti-RIMS3 antibody\nSee all RIMS3 primary antibodies\nDescriptionRabbit polyclonal to RIMS3\nSpecificityab67307 is predicted to have no cross-reactivity to other Rim proteins.\nTested applicationsSuitable for: WB, ICC/IF, IHC-Pmore details\nSpecies reactivityReacts with: Mouse, Rat, Human\nA 17 amino acid synthetic peptide from near the amino terminus of human RIMS3 (GenBank accession no. NP_055562).\n- Human brain tissue lysate.\nStorage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.\nStorage bufferPreservative: 0.02% Sodium azide\nConcentration information loading...\nPurityProtein A purified\nOur Abpromise guarantee covers the use of ab67307 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\n|WB||Use a concentration of 0.5 - 1 µg/ml. Detects a band of approximately 40 kDa (predicted molecular weight: 33 kDa).|\n|ICC/IF||Use a concentration of 20 µg/ml.|\n|IHC-P||Use at an assay dependent concentration.|\nRelevanceRIMS3 belongs to a family of synaptic proteins that are essential for normal neurotransmitter release. It localizes primarily to neuronal dendrites and the postsynaptic densities, indicating that it may contribute to synapse transmission and plasticity.\nCellular localizationCell junction, synapse.\n- KIAA0237 antibody\n- NIM 3 antibody\n- NIM3 antibody\nImmunofluorescence of RIMS3 in Human brain tissue with ab67307 at 5 ug/mL.\nImmunohistochemistry of Human brain tissue using ab67307 at 2.5 μg/ml.\nAll lanes : Anti-RIMS3 antibody (ab67307) at 1 µg/ml\nLane 1 : Human brain tissue lysate with no immunising peptide\nLane 2 : Human brain tissue lysate with immunising peptide\nLysates/proteins at 15 µg per lane.\nPredicted band size: 33 kDa\nObserved band size: 40 kDa why is the actual band size different from the predicted?\nab67307 has not yet been referenced specifically in any publications.", "domain": "chemistry", "round": 3} +{"url": "https://neuronimaging.ca/additionally-it-is-possible-the-fact-that-relationship-between-odcrp-and-oaz-or-between-odcrp-and-odc-occurs-even-if-it-cant-be-present-by-co-immunoprecipitation/", "date": "2022-10-01T13:39:01Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-40/segments/1664030336674.94/warc/CC-MAIN-20221001132802-20221001162802-00384.warc.gz", "language_score": 0.9124197363853455, "token_count": 1517, "dump": "CC-MAIN-2022-40", "global_id": "webtext-fineweb__CC-MAIN-2022-40__0__115082361", "lang": "en", "text": "Additionally it is possible the fact that relationship between ODCrp and OAZ or between ODCrp and ODC occurs even if it can’t be present by co-immunoprecipitation. ODC assays on lysates from transfected Cos-7 cells where ODCrp repressed the experience of endogenous ODC while Cys363Ala mutated ODCrp elevated the enzymatic activity of endogenous ODC. ?4 kb: forward primer 5-AGGGTCAGGATGTTCCTGTG, change primer 5-GAGAGCTTTGGCTCCTGATG; +30 kb: forwards primer 5-CAGCCCAGATGCAGAGTTTC, invert primer 5-TTCCAGCCTTTGAGTTTGCT). Outcomes from IP examples had been normalized to particular input test, as well as the outcomes (mean + S.E.M.) for four replicates are proven as percent of insight. DNA libraries from ChIP examples had been prepared regarding to Illuminas guidelines and sequenced using Illumina Genome Analyzer II. Top calling was performed using MACS algorithm sequencing and label pile-up was visualized using CD127 Integrative Genomics Viewers . qPCR Snap-frozen mouse organs (kidney, liver organ, human brain, lung, spleen, center, prostate, and testis) had been powderized and RNA was isolated using TRI Reagent (RNA/DNA/Proteins isolation reagent, Molecular Analysis Middle Inc., Ohio, U.S.A.) based on the producers guidelines. RNA (1 g) was utilized to create cDNA (Great Capacity RNA-to-cDNA Package, Applied Biosystems, Lifestyle Technology, Thermo Fisher Scientific Inc.) according to producers guidelines. The cDNA was after that utilized as template in qPCR (LightCycler, Roche) with enzyme combine (SYBR Green/ROX qPCR Get good at Combine (2), Thermo Scientific, Thermo Fisher Scientific Inc.) and particular primers (ODCrp: forwards primer 5-ACACACCTGAGAGCTACAGA and change primer 5-TCCTGGATCTAGGGAAGACT, 2M: forwards primer 5-ATGTCTCGATCCCAGTAGAC and change primer 5-GCTATCCAGAAAACCCCTCA). Test quantitations had been normalized using Gamitrinib TPP hexafluorophosphate the invariant endogenous control 2M. Finally, the outcomes (mean + S.D.) of 3 biological replicates had been Gamitrinib TPP hexafluorophosphate scaled to the full total consequence of neglected man control. Immunohistochemistry Five-micrometer heavy areas from formalin set and paraffin-embedded kidneys had been stained with 1:1200 diluted rabbit anti-ODCrp[A] antibody and using its preimmune serum as control using Vectastain Top notch ABC Package (Vector Laboratories Inc., Burlingame, U.S.A.) based on the producers guidelines seeing that described essentially. Light microscope photos had been used with an Olympus BX51 microscope (Olympus Optical, Tokyo, Japan) and a Nikon Digital View DS-5M camcorder (Nikon Company, Tokyo, Japan) using NIS-Elements F2.30 software program (Nikon Corporation). Digital picture digesting was performed with PhotoScape v3.6.1 (Mooii Technology, Informer Technology Inc., LA, U.S.A.). Cell transfections and cultures Cos-7 cells were cultured in DMEM moderate. ODC-deficient CHO cells (a sort present from Dr Lo Persson, Lund, Sweden), without endogenous ODC activity, had been cultured in RPMI-1640 moderate supplemented with putrescine. Both mass media also included 10% (v/v) FBS (Gibco, Lifestyle Technology, Thermo Fisher Scientific Inc.), Penicillin and L-glutamine and streptomycin. ODC-deficient CHO cells had been plated without putrescine 24 h before transfection. Cells had been transfected with the required plasmids using the FuGENE6 transfection reagent (Promega) based on the producers guidelines. In co-transfection tests, the transfection combine contained equal levels of both plasmids. Creation from the transfected protein was confirmed by SDS/Web page and immunoblotting. translation Radiolabeled translated protein had been created using an translation (IVT) package (TNT Combined Reticulocyte Lysate Program, Promega) based on the producers guidelines with L-[35S]-methionine (PerkinElmer, Waltham, U.S.A.). Examples of the translated protein and Amersham Rainbow [14C] methylated proteins molecular pounds marker (Amersham Biosciences, GE Health care Lifestyle Sciences, Chicago, U.S.A.) had been separated by SDS/Web page (12% gel). The gel was set for 30 Gamitrinib TPP hexafluorophosphate min in 30% methanol and 10% acetic acidity option and incubated for 1 h in Amplify Fluorographic Reagent (Amersham Biosciences). The gel was vacuum dried out (Model 853 Gel Clothes dryer, BioCRad, Hercules, U.S.A.) to filtration system paper for 2 h at 80C and utilized to expose an X-ray film (FUJI) right Gamitrinib TPP hexafluorophosphate away. Degradation assay Proteins degradation assay was performed seeing that described previously. From the translated proteins utilized, just ODC was radiolabeled. As a poor control, IVT lysate without translated protein was blended with radiolabeled ODC. The reactions had been create by blending 1 l OAZ with 14 l ODCrp/1C13ODCrp/AZIN1/lysate for 10 min at area temperatures. ODC (2 l) was put into the mixture, that was held at 4C for 5 min, whereafter prewarmed (37C) ATP-regenerating buffer (50 mM Tris/HCl, pH 7.5, 5 mM MgCl2, 2 mM DTT, 0.5 mM ATP, 10 mM p-creatine, and 5 g/ml creatine kinase) was put into a total level of 60 l. The reactions had been incubated at 37C and 5 l examples had been used after 0, 10, 30 min, and 1 h. The examples had been immediately blended with 2 Laemmli test buffer + 2-mercaptoethanol and separated by SDS/Web page (12% gel). Radiolabeled ODC was visualized Gamitrinib TPP hexafluorophosphate by fluorography. Catalytic activity assay The decarboxylase activity assay was performed as referred to previously by quantitating the discharge of 14CO2.", "domain": "chemistry", "round": 3} +{"url": "https://pubmed.ncbi.nlm.nih.gov/9688047/?dopt=Abstract", "date": "2022-08-18T17:25:01Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882573242.55/warc/CC-MAIN-20220818154820-20220818184820-00654.warc.gz", "language_score": 0.9278450608253479, "token_count": 365, "dump": "CC-MAIN-2022-33", "global_id": "webtext-fineweb__CC-MAIN-2022-33__0__177557634", "lang": "en", "text": "Purpose: To determine the functional presence ofa H+/peptide cotransport process in rabbit tracheal epithelial cell layers cultured at an air-interface and its contribution to transepithelial dipeptide transport.\nMethods: Rabbit tracheocytes were isolated, plated on Transwells, and cultured at an air-interface. After 5 or 6 days in culture, uptake and transepithelial transport of carnosine were examined.\nResults: Carnosine uptake by tracheocytes was pH-dependent and was saturable with a Michaelis-Menten constant of 170 microM. Moreover, carnosine uptake was inhibited 94% by Gly-L-Phe, 28% by beta-Ala-Gly, but not at all by Gly-D-Phe or by the amino acids beta-Ala and L-His. Unexpectedly. transepithelial carnosine transport at pH 7.4 (i.e., in the absence of a transepithelial pH gradient) was similar in both the apical-to-basolateral (ab) and basolateral-to-apical (ba) directions. Lowering the apical fluid pH to 6.5 reduced ab transport 1.6 times without affecting ba transport, consistent with predominantly paracellular diffusion of carnosine under an electrochemical potential gradient.\nConclusions: The kinetic behavior of carnosine uptake into cultured tracheal epithelial cell layers is characteristic of a H+-coupled dipeptide transport process known to exist in the small intestine and the kidney. Such a process does not appear to be rate-limiting in the transport of carnosine across the tracheal epithelial barrier.", "domain": "chemistry", "round": 3} +{"url": "https://www.eescorp.com/events/correcting-coal-ash-chemistry-with-coaltreat-leads-to-improved-boiler-operations/", "date": "2023-05-30T21:20:42Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-23/segments/1685224646144.69/warc/CC-MAIN-20230530194919-20230530224919-00664.warc.gz", "language_score": 0.9350296258926392, "token_count": 602, "dump": "CC-MAIN-2023-23", "global_id": "webtext-fineweb__CC-MAIN-2023-23__0__30403370", "lang": "en", "text": "Correcting Coal Ash Chemistry with CoalTreat Leads to Improved Boiler Operations\nThis webinar will help you make informed decisions about correcting fuel and coal ash chemistry to improve boiler performance and maximize fuel flexibility.\nFuel flexibility is essential for coal fired power plants to remain competitive in today’s power generation market. It is an effective way to both reduce generating costs and meet environmental regulations. Consequently, many coal fired power plants are taking advantage of low-cost, non-design, high sulfur coals such as ILB and NAP, while others are blending PRB coal to comply with stringent Hg and acid gas reductions mandated by MATS. Utilizing opportunity fuels offers tremendous economic and regulatory benefits, however, each of these coal choices bring a host of challenges associated with boiler slagging and fouling that impact unit operations.\nCoalTreat®, a fuel chemistry innovation developed by Environmental Energy Services (EES), has proven highly effective in mitigating problems attributed to furnace slagging, and heat transfer surface fouling. CoalTreatis applied to the fuel pre-combustion, customized to each plant’s fuels and specific objectives, and has been successfully deployed on several large fleet coal-fired units in the United States for many years resulting in:\n- Increased heat rate (efficiency) with improved heat transfer and reduced boiler exit gas temperature\n- Improved soot-blower performance and reduced forced outages (slag and tube wastage related outages)\n- Improved MW output through reducing or eliminating high load de-rating\nIn this informative webinar, Mark Pastore, Vice President Technology for EES, will review key elements that power plants must consider when using pre-combustion applied additives to correct fuel chemistry, improve boiler operations, reduce emissions and maximize fuel economics. Topics presented will include:\n- Fuel chemistry and how CoalTreat programs reduce slagging and fouling in coal-fired boilers\n- Improvements in heat transfer efficiency associated with reduced fouling of boiler surfaces\n- CoalTreat impact on ABS formation and removal of SO3 and acid gas\n- High Temperature Probe (HTP) testing, visual boiler inspections and plant DCS data to evaluate and optimize the performance of CoalTreat®\n- Expected ROI using CoalTreat® for coal fired power plants\nAdditionally, a case study will be discussed citing the performance, fuel flexibility, economics, and payback for a CoalTreat® program installed on a 680 MW unit firing ILB coal.\nMark Pastore | VP Technology | Environmental Energy Services\nMark Pastore is VP Clean Coal Solutions for EES, Inc. Mr. Pastore has been an expert in the field of fossil fuel treatment for acid gas emissions, slagging and fouling for 20 years. He has been instrumental in the deployment of EES Coal Treat Programs at several large coal fired power plants. Mark holds a BS in Chemistry from SUNY College at Purchase.", "domain": "chemistry", "round": 3} +{"url": "https://www.repository.cam.ac.uk/handle/1810/251238", "date": "2020-10-25T20:44:40Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-45/segments/1603107889651.52/warc/CC-MAIN-20201025183844-20201025213844-00212.warc.gz", "language_score": 0.6732307076454163, "token_count": 413, "dump": "CC-MAIN-2020-45", "global_id": "webtext-fineweb__CC-MAIN-2020-45__0__122982146", "lang": "en", "text": "Synthesis of a Precursor to Sacubitril Using Enabling Technologies\nBourne, Samuel L\nMachine‐Assisted Synthesis of a Precursor to Sacubitril\nMetadataShow full item record\nLau, S. H., Bourne, S. L., Martin, B., Schenkel, B., Penn, G., & Ley, S. (2015). Synthesis of a Precursor to Sacubitril Using Enabling Technologies. Organic Letters, 17 5436-5439. https://doi.org/10.1021/acs.orglett.5b02806\nAn efficient preparation of a precursor to the neprilysin inhibitor sacubitril is described. The convergent synthesis features a diastereoselective Reformatsky-type carbethoxyallylation and a rhodium-catalysed stereoselective hydrogenation for installation of the two key stereocenters. Moreover, by integrating machine-assisted methods with batch processes, this procedure allows a safe and rapid production of the key intermediates which are promptly transformed to the target molecule (3·HCl) over 7 steps in 54% overall yield.\nWe are grateful to Croucher Foundation (S.-H. L.) Novartis Pharma AG (S. L. B.) and the EPSRC (S. V. L., Grant Nos. EP/K0099494/1 and EP/K039520/1) for financial support. The crystallographic results in this paper were provided by Dr Andrew D. Bond (University of Cambridge).\nExternal DOI: https://doi.org/10.1021/acs.orglett.5b02806\nThis record's URL: https://www.repository.cam.ac.uk/handle/1810/251238\nCreative Commons Attribution 4.0 International License\nLicence URL: http://creativecommons.org/licenses/by/4.0/", "domain": "chemistry", "round": 3} +{"url": "https://svs.gsfc.nasa.gov/3256", "date": "2022-05-23T10:51:37Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-21/segments/1652662558015.52/warc/CC-MAIN-20220523101705-20220523131705-00183.warc.gz", "language_score": 0.8546572923660278, "token_count": 355, "dump": "CC-MAIN-2022-21", "global_id": "webtext-fineweb__CC-MAIN-2022-21__0__146595881", "lang": "en", "text": "A relatively warm Antarctic winter in 2005 kept the thinning of the protective ozone layer over Antarctica, known as the ozone 'hole,' slightly smaller than in 2004. The ozone hole is not technically a 'hole' where no ozone is present, but is actually a region of exceptionally depleted ozone in the stratosphere over the Antarctic that happens at the beginning of Southern Hemisphere spring (August-October). The average concentration of ozone in the atmosphere is about 300 Dobson Units; any area where the concentration drops below 220 Dobson Units is considered part of the ozone hole. Each year the 'hole' expands over Antarctica, sometimes reaching populated areas of South America and exposing them to ultraviolet rays normally absorbed by ozone. This data was acquired by the Ozone Monitoring Instrument on NASA's Aura satellite, NASA's newest tool to study this annual phenonmenon. On September 15, 2005, ozone thinning over Antarctica reached its maximum extent for the year at 24.2 million square kilometers (9.4 million square miles). The largest maximum area on record was 29.2 million square kilometers, in 2000.\nGCMD keywords can be found on the Internet with the following citation:\nOlsen, L.M., G. Major, K. Shein, J. Scialdone, S. Ritz, T. Stevens, M. Morahan, A. Aleman, R. Vogel, S. Leicester, H. Weir, M. Meaux, S. Grebas, C.Solomon, M. Holland, T. Northcutt, R. A. Restrepo, R. Bilodeau, 2013. NASA/Global Change Master Directory (GCMD) Earth Science Keywords. Version 188.8.131.52.0", "domain": "chemistry", "round": 3} +{"url": "https://www.samridhicrreation.com/post/universal-absorbent-solutions-booms-pillows-pads-and-socks-for-effective-spill-control", "date": "2024-04-19T18:51:22Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712296817442.65/warc/CC-MAIN-20240419172411-20240419202411-00185.warc.gz", "language_score": 0.9298703074455261, "token_count": 775, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__127897278", "lang": "en", "text": "Industries' common scenes are to see Spills and leaks, but what point to worry about is the risk it brings along with it, be it for the workers, the surroundings, and the equipment being handled or used. Thus, what can be done to prevent all of this mess? An effective management step has to be taken to manage and control such incidents if the backup was already prepared.\nLike how can the industries prepare themselves for such scenarios? The best way is to properly use the universal absorbent solutions that are seen as a crucial step in managing such spill issues. So, in this article that follows, we will explore the top 4 essential products one industry needs to have to be tolerant towards spill control: Universal Absorbent Booms, Universal Absorbent Pillows, Universal Absorbent Pads, and Universal Absorbent Socks. Each item mentioned above has specific features and applications contributing to a multifaceted spill response approach.\nPRODUCT-1: UNIVERSAL ABSORBENT BOOMS:\nUniversal Absorbent Booms are cylindrical liquid-containment and absorption barriers. These booms are especially useful when spills happen on water surfaces such as rivers, lakes, or ponds. They are made of long-lasting polymers that absorb oil and chemicals like hydrocarbons while resisting water. Universal Absorbent Booms are simple to set up and provide an effective method for minimizing spill spread.\nPRODUCT-2: UNIVERSAL ABSORBENT PILLOWS:\nIt is a product regularly seen to be a rectangular-shaped Universal Absorbent Pillow filled with extremely absorbent material. These adaptable items fit irregular surfaces and are suitable for use beneath leaking equipment, piping, or machinery. Universal Absorbent Pillows absorb liquids rapidly and efficiently, including oily substances, cooling fluids, solvents, and water-based fluids. They are crucial equipment for localized spill control and cleaning because of their adaptable and compact size.\nPRODUCT-3: UNIVERSAL ABSORBENT PADS:\nUniversal Absorbent Pads are versatile absorbing sheets that excel at spill and leak management. These pads come in a variety of dimensions and thicknesses as well, allowing for customization based on unique spill needs. They absorb various substances, including oil-based products, chemical compounds, and water-based fluids. Universal Absorbent Pads are often used to reduce the dangers connected with spills and leaks in industrial settings, laboratory settings, and transport industries.\nPRODUCT-4: UNIVERSAL ABSORBENT SOCKS:\nUniversal Absorbent Socks are flexible tubes filled with extremely absorbent polymers. They are sometimes known as absorbent booms or snakes. These socks are great for spill management and may be used to protect against spills to create a barrier that stops further spread. Universal Absorbent Socks are especially effective when spills occur in narrow spaces or areas with restricted access. They effectively adsorb chemical products, oil-based fluids goods, and other potentially hazardous fluids, lowering the risk of the contaminated area and acting as a crucial first line of defence.\nSpill management has always been a point of discussion for industrial people so, having a well-planned set up is highly crucial and necessary. This technique thus heavily relies on using products like Universal Absorbent Booms, Universal Absorbent Pillows, Universal Absorbent Pads, and Universal Absorbent Socks. Each of these products has its properties and applications, allowing for the best prevention of spills and leakages or from further contamination, absorption, and cleanup.\nThus, best way to protect from such accidental hazards is to protect the environment and safeguard the safety of your employees by adding these universal absorbent solutions from samridhi crreation into your spill response plan.", "domain": "chemistry", "round": 3} +{"url": "https://neurostresspep.eu/diner/npinfopage?neuropeptideID=34", "date": "2023-09-22T12:21:27Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233506399.24/warc/CC-MAIN-20230922102329-20230922132329-00815.warc.gz", "language_score": 0.8522214889526367, "token_count": 1228, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__223201698", "lang": "en", "text": "In an approach to identify novel neuropeptides in Drosophila a team of researchers employed liquid chromatography and tandem mass spectrometry on extract from larvae (Baggerman et al., 2002, 2005). Bioinformatics showed that several of the identified peptides are derived from four novel precursors, designated neuropeptide-like precursors 1-4 (NPLP1-4) encoded by the genes CG3441, CG11051, CG13061 and CG15361 (Baggerman et al., 2002, 2005).\nOf these, the NPLP1 has been most investigated. The NPLP1 precursor (CG3441) produces the four peptides IPNamide (NVGTLARDFQLPIPNamide), MTYamide (YIGSLARAGGLMTYamide), NAP peptide (SVAALAAQGLLNAP) and VQQ (NLGALKSSPVHGVQQ), which were confirmed by mass spectrometry (Baggerman et al., 2002). One more peptide could possibly be cleaved from the same precursor: NIATMARLQSAPSTHRDP (see Overend et al., 2012). The NPLP1 precursor is conserved in insects such as Apis mellifera (Hummon et al., 2006), Tribolium castaneum (Li et al., 2008), and Anopheles gambiae (Riehle et al., 2002). The receptor(s) of the NPLP1 peptides has not been identified, although it has been shown that one of the peptides, VQQ, activates the membrane receptor guanylate cyclase Gyc76c and stimulates cGMP production (Overend et al., 2012).\nThe NPLP2 precursor (CG11051) gives rise to the peptide TKAQGDFNEF, designated NEF peptide (Baggerman et al., 2002). A later mass spectrometry based study suggested that further peptides/fragments could be liberated from the precursor in Drosophila larvae that had been infected (Verleyen et al., 2006). The NPLP2 precursor has not been identified outside of Drosophila, except in the honeybee Apis mellifera (Hummon et al., 2006). No receptor has been identified.\nThe NPLP3 precursor (CG13061) can produce the peptides VVSVVPGAISHA (SHA peptide) and SVHGLGPVVIamide (VVIamide) (Baggerman et al., 2002). This precursor has only been identified in Drosophila species. No receptor has been identified.\nThe NPLP4 precursor (CG15361) can produce the peptide pQYYYGASPYAYSGGYYDSPYSY (YSYpeptide) (Baggerman et al., 2002). This precursor is not known outside Drosophila species. No receptor has been identified.\nNPLP1-derived IPNamide has been localized to 28 neurons in the larval ventral nerve cord of the flies Neobellieria (Sarcophaga) bullata and Drosophila melanogaster (Verleyen et al., 2004, 2009). Also, some NPLP expressing neurons in the brain were detected. Some of the neurons of the ventral nerve cord may be neurosecretory cells that release peptides into the circulation (see Overend et al., 2012). In the larval and adult Drosophila brain IPNamide is localized to a subset of the clock neurons, the anterior dorsal DN1 neurons (DN1a) and in the larval brain the DN1 neurons express this peptide (Shafer et al., 2006).\nThe NPLP2 precursor transcript is broadly expressed in the adult fly: highly expressed in most tissue except midgut, renal tubules, trachea, ovary and testes (FlyAtlas). In the larva, the hindgut, trachea, fat body, salivary glands and carcass are enriched for nplp2 transcript (FlyAtlas). RNA sequencing analysis of wing imaginal discs in Drosophila identified nplp2 transcript in flies mutant in Pacman, a gene encoding an exoribonuclease (Jones et al., 2016).\nThe NPLP3 precursor transcript is enriched in the eye and carcass of adult Drosophila according to FlyAtlas.\nAccording to FlyAtlas the NPLP4 precursor transcript is enriched in the eye, heart and hindgut of adult Drosophila; in the larva nplp4 is enriched in CNS, midgut, hindgut, salivary gland, carcass and especially trachea. It seems to be developmentally regulated.\nThe only function determined so far for any of the NPLP1-derived peptides is the action of VQQ peptide on the renal tubules of Drosophila (Overend et al., 2012). A likely role in circadian clock function and/or sleep is indicated by expression of IPNamide in a subset of clock neurons.\nUpon infection (bacterial injection) of Drosophila larvae a number of peptides are released into the haemolymph. It was found that among these were peptides derived from the NPLP2 precursor (Verleyen et al., 2006). Thus, these peptides could be part of a humoral antimicrobial defence. The presence of nplp2 in imaginal discs, together with insulin-like peptide 8, could indicate a role in developmental growth control (Jones et al., 2016).\nNo functions are known for NPLP-3 and 4.\nClick above image to go to SeqLogo and Cladogram page", "domain": "chemistry", "round": 3} +{"url": "https://mintir.com/bbs/board.php?bo_table=edu&wr_id=57&page=3", "date": "2020-09-29T01:25:45Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-40/segments/1600401617641.86/warc/CC-MAIN-20200928234043-20200929024043-00198.warc.gz", "language_score": 0.8905653357505798, "token_count": 794, "dump": "CC-MAIN-2020-40", "global_id": "webtext-fineweb__CC-MAIN-2020-40__0__217100617", "lang": "en", "text": "하이푸를 이용한 항암제 함유 온도민감 리포좀의 표적 전달능 평가를 위한 MRI의 역할: 동물실험 연구\n- 주저자 : Kim HR, Park SJ, Choi KS, You DG, Um W, Kim JH, Kim YS, Park JH - 영문 제목 : MRI monitoring of tumor-selective anticancer drug delivery with stable thermosensitive liposomes triggered by high-intensity focused ultrasound - 한글 제목 : 하이푸를 이용한 항암제 함유 온도민감 리포좀의 표적 전달능 평가를 위한 MRI의 역할: 동물실험 연구 - 저널 : Mol Pharmaceutics - 연도 : 2016 - 권 / 쪽 : 13 / 1528-1539 - 초록 : Monitoring of drug release from a heat-activated liposome carrier provides an opportunity for real-time control of drug delivery and allows prediction of the therapeutic effect. We have developed short-chain elastin-like polypeptide-incorporating thermosensitive liposomes (STLs). Here, we report the development of STL encapsulating gadobenate dimeglumine (Gd-BOPTA), a MRI contrast agent, and doxorubicin (Dox) (Gd-Dox-STL). The Dox release profile from Gd-Dox-STL was comparable to Gd-Dox-LTSL; however, the serum stability of Gd-Dox-STL was much higher than Gd-Dox-LTSL. MRI studies showed that the difference in T1 relaxation time between 37 and 42 °C for Gd-Dox-STL was larger than the difference for Gd-Dox-LTSL. Although relaxivity for both liposomes at 42 °C was similar, the relaxivity of Gd-Dox-STL at 37 °C was 2.5-fold lower than that of Gd-Dox-LTSL. This was likely due to Gd-BOPTA leakage from the LTSL because of low stability at 37 °C. Pharmacokinetic studies showed plasma half-lives of 4.85 and 1.95 h for Gd-Dox-STL and Gd-Dox-LTSL, respectively, consistent with in vitro stability data. In vivo MRI experiments demonstrated corelease of Dox and Gd-BOPTA from STL under mild hyperthermia induced by high-intensity focused ultrasound (HIFU), which suggests STL is a promising tumor selective formulation when coupled with MR-guided HIFU.\nKEYWORDS: MRI; drug release monitoring; elastin-like polypeptide; heat-triggered drug release; intratumoral accumulation; thermosensitive liposome", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/prostaglandin-e-synthasempges-1-antibody-ab23727.html", "date": "2020-07-14T15:56:53Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-29/segments/1593655897168.4/warc/CC-MAIN-20200714145953-20200714175953-00076.warc.gz", "language_score": 0.6651493906974792, "token_count": 480, "dump": "CC-MAIN-2020-29", "global_id": "webtext-fineweb__CC-MAIN-2020-29__0__99545809", "lang": "en", "text": "Key features and details\n- Rabbit polyclonal to Prostaglandin E Synthase/MPGES-1\n- Suitable for: WB\n- Reacts with: Human\n- Isotype: IgG\nProduct nameAnti-Prostaglandin E Synthase/MPGES-1 antibody\nSee all Prostaglandin E Synthase/MPGES-1 primary antibodies\nDescriptionRabbit polyclonal to Prostaglandin E Synthase/MPGES-1\nTested applicationsSuitable for: WBmore details\nSpecies reactivityReacts with: Human\nFull length protein corresponding to Sheep Prostaglandin E Synthase/MPGES-1.\nPreviously labelled as Prostaglandin E Synthase\nStorage instructionsShipped at 4°C. Upon delivery aliquot. Avoid freeze / thaw cycle.\nStorage bufferConstituent: PBS\nConcentration information loading...\nOur Abpromise guarantee covers the use of ab23727 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\nNot tested in other applications.\nOptimal dilutions/concentrations should be determined by the end user.\nFunctionCatalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2).\nSequence similaritiesBelongs to the MAPEG family.\n- Information by UniProt\n- Glutathione S transferase 1 like 1 antibody\n- MGC10317 antibody\n- MGST IV antibody\nAll lanes : Anti-Prostaglandin E Synthase/MPGES-1 antibody (ab23727) at 1/1000 dilution\nLane 1 : Vector transfected HCT116 cell lysate\nLane 2 : Prostaglandin E Synthase / MPGES-1 transfected HCT116 cell lysate\nDeveloped using the ECL technique.\nPredicted band size: 17 kDa\nObserved band size: 17 kDa\nExposure time: 2 hours\nab23727 has not yet been referenced specifically in any publications.", "domain": "chemistry", "round": 3} +{"url": "https://tajrc.kaust.edu.sa/publications/detail/iron-deficiency-in-seagrasses-and-macroalgae-in-the-red-sea-is-unrelated-to-latitude-and-physiological-performance", "date": "2024-03-05T14:07:09Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707948235171.95/warc/CC-MAIN-20240305124045-20240305154045-00056.warc.gz", "language_score": 0.8390914797782898, "token_count": 430, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__51855026", "lang": "en", "text": "Iron Deficiency in Seagrasses and Macroalgae in the Red Sea Is Unrelated to Latitude and Physiological Performance\nbyAndrea Anton, Iris E. Hendriks, Núria Marbà, Dorte Krause-Jensen, Neus Garcias-Bonet, Carlos M. Duarte\nAnton, A., Hendriks, I. E., Marba, N., Krause-Jensen, D., Garcias-Bonet, N., & Duarte, C. M. (2018). Iron deficiency in seagrasses and macroalgae in the Red Sea is unrelated to latitude and physiological performance. Frontiers in Marine Science, 5, 74.\nIron can limit primary production in shallow marine systems, especially in tropical waters characterized by carbonated sediments, where iron is largely trapped in a non-available form. The Red Sea, an oligotrophic ecosystem characterized by a strong N-S latitudinal nutrient gradient, is a suitable setting to explore patterns in situ of iron limitation in macrophytes and their physiological performance under different iron regimes. We assessed the interactions between environmental gradients and physiological parameters of poorly-studied Red Sea macrophytes. Iron concentration, chlorophyll a concentration, blade thickness, and productivity of 17 species of macrophytes, including seven species of seagrasses and 10 species of macroalgae, were measured at 21 locations, spanning 10 latitude degrees, along the Saudi Arabian coast. Almost 90% of macrophyte species had iron concentrations below the levels indicative of iron sufficiency and more than 40% had critically low iron concentrations, suggesting that iron is a limiting factor of primary production throughout the Red Sea. We did not identify relationships between tissue iron concentration, chlorophyll a concentration and physiological performance of the 17 species of seagrass and macroalgae. There was also no latitudinal pattern in any of the parameters studied, indicating that the South to North oligotrophication of the Red Sea is not reflected in iron concentration, chlorophyll a concentration or productivity of Red Sea macrophytes.", "domain": "chemistry", "round": 3} +{"url": "http://www.wiley.com/WileyCDA/WileyTitle/productCd-0471248231.html", "date": "2017-10-23T04:37:01Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-43/segments/1508187825575.93/warc/CC-MAIN-20171023035656-20171023055656-00558.warc.gz", "language_score": 0.7338224053382874, "token_count": 463, "dump": "CC-MAIN-2017-43", "global_id": "webtext-fineweb__CC-MAIN-2017-43__0__164786988", "lang": "en", "text": "Course Notes on the Interpretation of Infrared and Raman Spectra\n- Generously enriched with sample exercises to help rapidly develop powerful interpretive skills.\n- Includes appendices with fourteen bibliographies by subject area.\n1. Introduction (Foil A. Miller).\n2. Characteristic Frequencies of Alkanes (Dana W. Mayo).\n3. Characteristic Frequencies of Alkenes (Olefins) (Foil A. Miller).\n4. Characteristic Frequencies of Molecules with Triple Bonds and Cumulated Double Bonds (Robert W. Hannah and Foil A. Miller).\n5. Characteristic Frequencies of Aromatic Compounds (Group Frequencies of Arenes) (Dana W. Mayo).\nINTRODUCTION TO EXERCISES.\nEXERCISE SECTION I.\n6. Spectra of X–H Systems (With Emphasis on O—H and N—H Groups) (Foil A. Miller).\n7. Spectra of Carbonyl Compounds of All Kinds (Factors Affecting Carbonyl Group Frequencies) (Dana W. Mayo).\n8. Amides, Carboxylate Ion, and C-O Single Bonds (Foil A. Miller).\n9. Groups Containing N=O Bonds, or Si, P, S, or Halogen Atoms (Robert W. Hannah).\nEXERCISE SECTION II.\n10. Infrared Spectra of Polymers: Introduction (Robert W. Hannah and Dana W. Mayo).\n11. Infrared Spectra of Inorganic Materials (Foil A. Miller).\n12. Survey of Infrared and Raman Group Frequencies (Dana W. Mayo).\nEXERCISE SECTION III.\n13. Sample-Handling Techniques (Robert W. Hannah).\n14. Infrared Spectra of Mixtures (Robert W. Hannah).\nAnswer to Chapter 5 Figure 5-30.\nAnswers to Exercises.\nFoil A. Miller is Professor Emeritus and former director of the Spectroscopy Laboratory at the University of Pittsburgh.\nRobert W. Hannah is the former director of research for the Instrument Group at Perkin-Elmer.", "domain": "chemistry", "round": 3} +{"url": "http://www.astm.org/DATABASE.CART/STD_REFERENCE/C279.htm", "date": "2013-05-21T06:33:05Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2013-20/segments/1368699755211/warc/CC-MAIN-20130516102235-00062-ip-10-60-113-184.ec2.internal.warc.gz", "language_score": 0.7186509966850281, "token_count": 253, "dump": "CC-MAIN-2013-20", "global_id": "webtext-fineweb__CC-MAIN-2013-20__0__102317777", "lang": "en", "text": "ASTM C279 - 12 Standard Specification for Chemical-Resistant Masonry Units\nCiting ASTM Standards Citation data is made available by participants in CrossRefs Cited-by Linking service. A comprehensive list of citations to this standard are listed here.\nC308 Standard Test Methods for Working, Initial Setting, and Service Strength Setting Times of Chemical-Resistant Resin Mortars\nC321 Standard Test Method for Bond Strength of Chemical-Resistant Mortars\nC395 Standard Specification for Chemical-Resistant Resin Mortars\nC397 Standard Practice for Use of Chemically Setting Chemical-Resistant Silicate and Silica Mortars\nC398 Standard Practice for Use of Hydraulic Cement Mortars in Chemical-Resistant Masonry\nC399 Standard Practice for Use of Chemical-Resistant Resin Mortars\nC410 Standard Specification for Industrial Floor Brick\nC466 Standard Specification for Chemically Setting Silicate and Silica Chemical-Resistant Mortars\nC515 Standard Specification for Chemical-Resistant Ceramic Tower Packings\nC1232 Standard Terminology of Masonry\nReferenced ASTM Standards The documents listed below are referenced within the subject standard but are not provided as part of the standard.", "domain": "chemistry", "round": 3} +{"url": "http://cura-cancer.com/hmof-myst1-a-histone-acetyltransferase-head-wear-forms-at-least-two/", "date": "2022-08-18T22:58:24Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882573533.87/warc/CC-MAIN-20220818215509-20220819005509-00171.warc.gz", "language_score": 0.9235023260116577, "token_count": 1142, "dump": "CC-MAIN-2022-33", "global_id": "webtext-fineweb__CC-MAIN-2022-33__0__181751150", "lang": "en", "text": "hMOF (MYST1) a histone acetyltransferase (Head wear) forms at least two distinct multiprotein complexes in human cells. regulations such as ATP-dependent remodeling of nucleosomes the incorporation of variants histones into nucleosomes and post-translational modifications of histones . Post-translational modifications of the N-terminal tails of histones including acetylation methylation phosphorylation ubiquitination and ADP-ribosylation may act alone or in a coordinated manner to facilitate or repress chromatin-mediated processes -. Crosstalk between different adjustments could be accomplished by a genuine amount of systems. For example a short histone adjustment may cause increased activity of a histone-modifying enzyme. Additionally one histone and its own modifications influence the modification of the different histone . Hence acetylation of histone H3 on lysine 18 and lysine 23 promotes the methylation of argine 17 with the CARM1 (coactivator-associated arginine methyltransferase 1) methyltransferase leading to activation of estrogen-responsive genes . Also methylation of H3K4 by COMPASS (complicated of proteins connected with Established1) and of H3K79 by Dot1 is very influenced by the ubiquitylation of H2BK123 by Rad6/Bre1 in genome recommending the functional variety of MOF . Latest biochemical purifications possess uncovered that MOF forms at least two specific multi-protein complexes MSL and NSL in and mammalian cells -. Even though the features of MSL and NSL complexes in individual cells aren’t entirely very clear both complexes can acetylate histone H4 at lysine 16 (H4K16) recommending the need for acetylation of H4K16 in cells -. Besides H4K16 NSL complicated is also in a position to acetylate various other histone H4 lysines such as for example H4K5 and H4K8 . Intriguingly NSL complicated is apparently involved in even more global transcription legislation as it continues to be discovered to bind to a subset Primidone (Mysoline) of energetic promoters and donate to housekeeping gene appearance in Head wear Primidone (Mysoline) and HMT assays had been performed. As forecasted Flag-WDR5 is connected with both histone acetyltransferase that may acetylate HeLa cell-derived nucleosomes on histone H4 and histone methytransferase that may support mono- di- and tri-methylation of histone H3 on lysine 4 (H3K4me1 H3K4me2 and H3K4me3) in recombinant histone octamers. On the other hand complexes formulated with Flag-Ash2 (a subunit distributed between MLL and Place1-formulated with complexes) copurified just with HMT activity (Body 1B). To help expand investigate the interplay between H3K4 methylation and H4 acetylation by Flag-WDR5-formulated with complexes we performed mixed assays for Head wear and HMT where reactions contained both acetyl group donor acetyl CoA (AcCoA) as well as the methyl group donor S-adenosyl methionine (SAM). Even though the HAT activity connected with Flag-WDR5 complicated had not been affected in the current presence of SAM (S-adenosyl methionine a methyl donor) (Body 1C) HMT activity was significantly increased in the current presence of AcCoA-dependent way (Body 1D). hMOF-mediated CCR7 acetylation makes up about the positive legislation of H3K4 methylation by MLL/Place complexes To determine if the AcCoA-dependent upsurge in H3K4 methylation Primidone (Mysoline) activity connected with Flag-WDR5-formulated with complexes is certainly mediated by hMOF complicated(ha sido) we produced HA-tagged hMOF formulated with a spot mutation G327E in an extremely conserved residue Primidone (Mysoline) in the hMOF Head wear domain (Body 2A best) . Complexes formulated with outrageous type or mutant HA-tagged MOF purified using anti-HA agarose immunoaffinity chromatography from 293FRT cell lines stably expressing HA-hMOF outrageous type (hMOFwt) or HA-hMOF G327E (hMOFmt) and fractionated them by SDS-PAGE. As proven in Body 2A (still left) an identical group of polypeptides could possibly be discovered in both hMOFwt and hMOFmt complexes by sterling silver staining. To regulate how the G327E mutation impacts hMOF activity HA-hMOFwt and HA-hMOFmt complexes formulated with equivalent levels of hMOF (Body 2A correct) were put through HAT assays. The outcomes of these tests indicated that this HAT activity associated with HA-hMOFmt was dramatically reduced (Physique 2B lane 5-7) compared to HA-hMOFwt (Physique 2B lane 2-4). To test the role of hMOF-dependent HAT.", "domain": "chemistry", "round": 3} +{"url": "https://generalnewsworld.com/this-supplement-may-be-the-key-to-your-fitness-goals-this-year/", "date": "2021-02-27T04:20:58Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-10/segments/1614178358064.34/warc/CC-MAIN-20210227024823-20210227054823-00015.warc.gz", "language_score": 0.9647079110145569, "token_count": 321, "dump": "CC-MAIN-2021-10", "global_id": "webtext-fineweb__CC-MAIN-2021-10__0__196376914", "lang": "en", "text": "Once you take NR, your physique converts it into nicotinamide adenine dinucleotide (NAD+), a coenzyme that exists in all cells and elements into power metabolism and your potential to keep up correct cell functioning. NAD+ additionally performs an important function in your power ranges: NAD+ is what fuels your mitochondria, which inturn fuels your physique by creating power. This, researchers assume, is how the complement aids in restoration: By supporting cell rejuvenation thereby serving to your physique get well and rebuild between exercises.\nIn truth, one animal examine confirmed that growing ranges of NAD+ additionally might assist enhance muscle operate as you age. The examine, revealed within the journal Cell Metabolism, discovered that mice that had depleted levels of NAD+ had a “dramatic” drop in their muscle strength and endurance on a treadmill, implying that NAD+ is a vital element of energy and endurance.*\nIn one other examine, researchers used mice whose genes had been altered so their muscle tissue contained solely 15% of the traditional quantity of NAD+. They then measured muscle energy and endurance, which was fairly low. However after giving the mice NR-enriched water for only a week, their exercise capacity was that of a normal, wholesome mouse.* And in a single extra mouse examine, supplementation with NAD+ precursors led to better-supported DNA repair and health of muscle tissue inside the first week—to the purpose the place researchers could not inform the distinction between the tissue of a mouse that was 2 years previous versus a mouse that was 4 months previous.*", "domain": "chemistry", "round": 3} +{"url": "https://ndclist.com/ndc/78951-005", "date": "2020-08-10T02:56:05Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-34/segments/1596439738603.37/warc/CC-MAIN-20200810012015-20200810042015-00297.warc.gz", "language_score": 0.7791872620582581, "token_count": 289, "dump": "CC-MAIN-2020-34", "global_id": "webtext-fineweb__CC-MAIN-2020-34__0__37086451", "lang": "en", "text": "The product labeling information includes all published material associated to a drug. Product labeling documents include information like generic names, active ingredients, ingredient strength dosage, routes of administration, appearance, usage, warnings, inactive ingredients, etc.\nAlcohol 75% v/v. Purpose: Antimicrobial\nAntimicrobial, Hand Sanitizer\n- Hand sanitizer to reduce bacteria on the skin that could cause disease.recommended for repeated use\nFlammable. Keep away from heat or flame. For external use only.\nWhen Using This Product\nDo not use in or near eyes. In case of contact with eyes, flush eyes thoroughly with water.\nStop Use And Ask A Doctor If\nIrritation or rash appears and lasts\nOtc - Keep Out Of Reach Of Children\nKeep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away.\n- Place enough product in your palm to thoroughly cover your handsRub hands together briskly until dryChildren under 6 years of age should be supervised when using\nDo not store above 110F (43C)May discolor certain fabrics or surfaces\nWater (Aqua), caprylyl glycol, phenoxyethanol, acrylates/c10-30 alkyl acrylate crosspolymer, isopropyl myristate, triethanolamine\n* Please review the disclaimer below.", "domain": "chemistry", "round": 3} +{"url": "https://www.ishs.org/ishs-article/755_22", "date": "2022-08-10T12:04:07Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571153.86/warc/CC-MAIN-20220810100712-20220810130712-00252.warc.gz", "language_score": 0.9206623435020447, "token_count": 624, "dump": "CC-MAIN-2022-33", "global_id": "webtext-fineweb__CC-MAIN-2022-33__0__126543667", "lang": "en", "text": "NUTRIENT REMOBILIZATION DURING POLLINATION-INDUCED COROLLA SENESCENCE IN PETUNIA\nSenescence represents the last stage of flower development. The premature senescence of flowers caused by environmental stresses during shipping, storage or retailing reduces the salability of ornamentals. Delaying flower senescence increases shelf life and post production quality, thereby increasing the value of ornamental plants. Corolla senescence is accompanied by increased activity of proteases and nucleases. These enzymes are believed to function in the large-scale degradation of proteins and nucleic acids, which allows the plant to salvage essential nutrients from dying petals before they are shed. Pollination accelerates corolla senescence in many species. Similar changes in nucleases and proteases are detected in petunia corollas during the age-related senescence of unpollinated flowers and the accelerated senescence of pollinated flowers, but it is unclear whether nutrient remobilization is similar. The objective of this research was to investigate the nutrient changes during pollination-induced corolla senescence. Plant macronutrients, micronutrients and additional elements were measured from nonsenescing corollas on the day of flower opening and compared to levels in corollas at the advanced stage of senescence. Nutrient levels were also measured at various times after pollination. Carbon, nitrogen, phosphorus, potassium, sulfur, iron, molybdenum, and zinc were reduced during pollination-induced senescence. In contrast, only carbon, nitrogen, phosphorus and copper were found to be reduced in corollas during the senescence of unpollinated flowers. These studies suggest that a different nutrient remobilization program is occurring during pollination-induced senescence and this may be due to the different sink tissues and how the nutrients are transported. Nutrients in pollinated flowers are likely being remobilized to the developing ovary, while in unpollinated flowers they are being transported to sink tissues outside of the flower. In order to understand the senescence program in flowers it is necessary to study the process in unpollinated and pollinated flowers.\nChapin , L. and Jones, M. (2007). NUTRIENT REMOBILIZATION DURING POLLINATION-INDUCED COROLLA SENESCENCE IN PETUNIA. Acta Hortic. 755, 181-190\nflower senescence, petals, phosphorus, nitrogen, programmed cell death, ornamentals, postharvest", "domain": "chemistry", "round": 3} +{"url": "https://www.hindawi.com/journals/jnp/2013/549502/ref/", "date": "2017-02-25T16:53:05Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-09/segments/1487501171781.5/warc/CC-MAIN-20170219104611-00558-ip-10-171-10-108.ec2.internal.warc.gz", "language_score": 0.7543809413909912, "token_count": 1319, "dump": "CC-MAIN-2017-09", "global_id": "webtext-fineweb__CC-MAIN-2017-09__0__38899500", "lang": "en", "text": "- About this Journal ·\n- Abstracting and Indexing ·\n- Aims and Scope ·\n- Annual Issues ·\n- Article Processing Charges ·\n- Articles in Press ·\n- Author Guidelines ·\n- Bibliographic Information ·\n- Citations to this Journal ·\n- Contact Information ·\n- Editorial Board ·\n- Editorial Workflow ·\n- Free eTOC Alerts ·\n- Publication Ethics ·\n- Reviewers Acknowledgment ·\n- Submit a Manuscript ·\n- Subscription Information ·\n- Table of Contents\nJournal of Nanoparticles\nVolume 2013 (2013), Article ID 549502, 5 pages\nGreen Chemistry Approach for Efficient Synthesis of Schiff Bases of Isatin Derivatives and Evaluation of Their Antibacterial Activities\n1Department of Pharmaceutical Chemistry, Roland Institute of Pharmaceutical Sciences and Berhampur, Odisha 760010, India\n2University Institute of Pharmaceutical Sciences, UGC Centre of Advanced Study (CAS), Panjab University, Chandigarh 160014, India\nReceived 31 December 2012; Accepted 12 January 2013\nAcademic Editor: Amir Kajbafvala\nCopyright © 2013 Jnyanaranjan Panda et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.\n- M. Charde, A. Shukla, V. Bukhariya, J. Mehta, and R. Chakole, “A review on: a significance of microwave assist technique in green chemistry,” International Journal of Phytopharmacy, vol. 2, no. 2, pp. 39–50, 2012.\n- S. Ravichandran and E. Karthikeyan, “Microwave synthesis—a potential tool for green chemistry,” International Journal of ChemTech Research, vol. 3, no. 1, pp. 466–470, 2011.\n- S. Sharma, S. Gangal, and A. Rauf, “Green chemistry approach to the sustainable advancement to the synthesis of heterocyclic chemistry,” Rasayan Journal of Chemistry, vol. 1, no. 4, pp. 693–717, 2008.\n- M. Kidwai, “Green chemistry trends toward sustainability,” Pure and Applied Chemistry, vol. 78, no. 11, pp. 1983–1992, 2006.\n- H. M. Mamun, M. A. Foysal, and M. Mahabub, “Microwave-assisted efficient synthesis of isatins and spiro-thiadiazolines under green chemistry protocol,” Journal of Scientific Research, vol. 2, no. 2, pp. 322–329, 2010.\n- A. Kulshrestha and S. Baluja, “Microwave promoted synthesis of some Schiff bases,” Archives of Applied Science Research, vol. 2, no. 3, pp. 221–224, 2010.\n- R. Somani, S. Pawar, S. Nikam, P. Shirodkar, and V. Kadam, “Microwave assisted synthesis and antimicrobial activity of some Schiff's bases,” International Journal of ChemTech Research, vol. 2, no. 2, p. 860, 2010.\n- S. K. Sridhar, S. N. Pandeya, J. P. Stables, and A. Ramesh, “Anticonvulsant activity of hydrazones, Schiff and Mannich bases of isatin derivatives,” European Journal of Pharmaceutical Sciences, vol. 16, no. 3, pp. 129–132, 2002.\n- S. N. Pandeya, D. Sriram, G. Nath, and E. De Clercq, “Synthesis and antimicrobial activity of Schiff and Mannich bases of isatin and its derivatives with pyrimidine,” Farmaco, vol. 54, no. 9, pp. 624–628, 1999.\n- A. Jarrahpour, D. Khalili, E. De Clercq, C. Salmi, and J. M. Brunel, “Synthesis, antibacterial, antifungal and antiviral activity evaluation of some new bis-Schiff bases of isatin and their derivatives,” Molecules, vol. 12, no. 8, pp. 1720–1730, 2007.\n- S. S. Chhajed and M. S. Padwal, “Antimicrobial evaluation of some novel Schiff and Mannich bases of isatin and its derivatives with quinolin,” International Journal of ChemTech Research, vol. 2, no. 1, pp. 209–213, 2010.\n- T. R. Bal, B. Anand, P. Yogeeswari, and D. Sriram, “Synthesis and evaluation of anti-HIV activity of isatin β-thiosemicarbazone derivatives,” Bioorganic and Medicinal Chemistry Letters, vol. 15, no. 20, pp. 4451–4455, 2005.\n- M. Verma, S. N. Pandeya, K. N. Singh, and J. P. Stables, “Anticonvulsant activity of Schiff bases of isatin derivatives,” Acta Pharmaceutica, vol. 54, no. 1, pp. 49–56, 2004.\n- S. H. Gillespie, Medical Microbiology-Illustrated, Butterworth Heinemann, London, UK, 1994.\n- U. K. Singh, S. N. Pandeya, A. Singh, B. K. Srivastava, and M. Pandey, “Synthesis and antimicrobial activity of Schiff’s and N-Mannich bases of isatin and its derivatives with 4-Amino-N-carbamimidoyl benzene sulfonamide,” International Journal of Pharmaceutical Sciences and Drug Research, vol. 2, no. 2, pp. 151–154, 2010.", "domain": "chemistry", "round": 3} +{"url": "http://www.ehow.co.uk/how_6503081_remove-perspiration-smell-clothing.html", "date": "2018-05-25T03:44:14Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-22/segments/1526794866938.68/warc/CC-MAIN-20180525024404-20180525044404-00100.warc.gz", "language_score": 0.9280105829238892, "token_count": 365, "dump": "CC-MAIN-2018-22", "global_id": "webtext-fineweb__CC-MAIN-2018-22__0__43238839", "lang": "en", "text": "If you have an article of clothing that smells like sweat, you likely want the clothing to smell better. Perspiration odours on clothing are both embarrassing and bothersome. Sweating is something natural that happens to the body that is beyond our control. Removing perspiration smells from clothing is something that we can control. You likely have all you need to remove perspiration odours from clothing right inside of your cabinets.\nHang the smelly clothing outside in the sun for a few hours. Exposing the item to sunlight will help to eliminate the odour.\nPour ½ cup water and 1 tbsp ammonia into a bowl. Use a spoon to combine the ingredients.\nPour the mixture over the area of the clothing that smells. If you want to soak the whole piece of clothing, make the mixture in a bucket and use 1 tbsp ammonia for each ½ cup water.\nAllow the clothing to soak in the ammonia solution for at least one hour. Wash the clothing as usual.\nSoak the smelly parts of the clothing in rubbing alcohol if the odour persists. Pour rubbing alcohol directly onto the affected areas. Let it soak for several hours and then rinse with warm water and launder as usual.\nAdd 2 cups of baking soda along with washing powder to your wash load. This will help to freshen up the entire load of laundry, including the item of clothing with perspiration odours.\nFor another odour-eliminator, make a paste of baking soda and water and rub it onto the smelly areas of the clothing. Let it sit for about 20 minutes then launder as usual. Yet another alternative for removing perspiration odours is to soak the clothing in a bucket filled with warm water and 1 cup white vinegar. Let it sit overnight before washing the clothing.", "domain": "chemistry", "round": 3} +{"url": "https://distributionbizwiz.wordpress.com/2007/07/24/when-is-a-virgin-not-a-virgin/", "date": "2018-03-22T19:38:58Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-13/segments/1521257648000.93/warc/CC-MAIN-20180322190333-20180322210333-00223.warc.gz", "language_score": 0.9225348830223083, "token_count": 388, "dump": "CC-MAIN-2018-13", "global_id": "webtext-fineweb__CC-MAIN-2018-13__0__256559168", "lang": "en", "text": "…When It’s Mechanical\nVirgin plastic means that the resin used in the manufacturing process of plastic sheet, rod, or tube has never been used before – fresh out of the gaylord and fresh off the truck from the resin manufacturer.\nGaylord Of Plastic Resin\nThe resin is sent to a converter who pours the resin into a machine that heats it up and squishes out through a press or die, much like you did with plasticine as a kid. As in the picture below, the sheet is made bigger than actually required so that it can be cut square and true much like trimming a cake.\nThese “left-overs” are then reground back into small resin-sized pieces and recycled into plastic sheet but it can’t be called virgin anymore because it’s been processed at least once. This grade is referred to as mechanical or regrind. Providing the manufacturing process is clean then the reground product has virtually the same properties as virgin material but it’s not virgin.\nIn materials like UHMW the reground material is often mixed with differing colours to create a uni-blend or marbled look differentiating it from the virgin material. Mechanical grade polycarbonate appears more milky (less translucent?!?!) then virgin polycarb. Mechanical grade Teflon has a grey tinge to the material and attracts dust giving it even a dirtier look but it’s still Teflon.\nNot all plastics can be reground because of the thermal nature of the material – you can only use it once and then it’s off to the landfill (refer to my article on recycling.)\nIf you have a spec that requires virgin material then this requirement should be on your purchase order and you can always request a Certificate Of Compliance (CofC) to verify the grade of the material, too.", "domain": "chemistry", "round": 3} +{"url": "http://tula-svai.ru/library/advanced-catalysts-and-nanostructured-materials-modern-synthetic-methods", "date": "2019-10-22T19:36:58Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-43/segments/1570987823061.83/warc/CC-MAIN-20191022182744-20191022210244-00068.warc.gz", "language_score": 0.7172544002532959, "token_count": 968, "dump": "CC-MAIN-2019-43", "global_id": "webtext-fineweb__CC-MAIN-2019-43__0__36605296", "lang": "en", "text": "By William R. Moser\nThe time has come for an evaluation of crucial concepts for the fabrication of complex catalysts. Catalyst construction by myself is greater than one thousand million buck enterprise every year, and the product worth of chemical techniques utilizing complicated catalysts is some trillion cash every year. This booklet seeks to supply a latest, fabrics technology account of the easiest and most present ideas for the synthesis of complex catalytic materials.\nUntil now, there was no unmarried e-book which incorporates a definitive and accomplished description of the real applied sciences for catalyst synthesis in the context of contemporary fabrics technology. educational researchers either within the catalytic sciences and fabrics sciences should have the simplest synthesis applied sciences to be had to complete the practise of solid-state fabrics of particular constitution and morphology. Althugh the emphasis is on new man made concepts for catalytic purposes, the bookpresents the entire vital applied sciences for the fabrication of digital and structural ceramics, and superconductors.\n- Novel strategies for complicated Materials\n- Nanostructured fabrics Synthesis\n- Mesoporous Molecular Sieves\n- Pillared Clays\n- Heteropoly Acids\n- Nanostructured Supported steel Catalysts\n- Nanostructured steel Oxide Catalysts and Materials\n- Nanostructured Zeolite Materials\n- Vapor section fabrics Synthesis\n- Sonochemical fabrics Synthesis\n- Aerosol tools of Catalyst Synthesis\n- Hydrodynamic Cavitational concepts for Catalyst and fabrics Synthesis\n- Novel Sol-Gel tools for Catalyst Synthesis\n- Supercritical tools for fabrics Synthesis\n- Liquid Crystal ideas for Mesoporous Materials\n- Micelle options for Nanostructured Catalyst Preparation\n- Fluidized mattress concepts in Chemical Vapor Deposition\n- Flame equipment of complex Catalyst Synthesis\nRead or Download Advanced Catalysts and Nanostructured Materials: Modern Synthetic Methods PDF\nSimilar industrial & technical chemistry books\nNutrition proteins represent a various and intricate selection of organic macro molecules. even though contributing to the dietary caliber of the meals we con sume, proteins additionally act as critical parts by way of advantage in their different sensible homes. The expression of those useful homes through the instruction, processing and garage of meals is basically dictated by means of alterations to the constitution or structure-related homes of the proteins concerned.\nTargeting the most important demanding situations that also bog down the belief of the billion-ton renewable fuels imaginative and prescient, this booklet integrates technological improvement and enterprise improvement rationales to focus on the most important technological. advancements which are essential to industrialize biofuels on a world scale.\nMit einem neuen Herausgeberteam wird das Buch 'Industrielle Anorganische Chemie' grundlegend uberarbeitet weitergefuhrt. Das Lehrwerk bietet in hervorragend ubersichtlicher, knapp und prazise gehaltener shape eine aktuelle Bestandsaufnahme der industriellen anorganischen Chemie. Zu Herstellungsverfahren, wirtschaftlicher Bedeutung und Verwendung der Produkte, sowie zu okologischen Konsequenzen, Energie- und Rohstoffverbrauch bieten die Autoren einen fundierten Uberblick.\nThis publication discusses how a lot different nations replicate the european chemical law achieve (Registration, overview, Authorization, limit of Chemicals), within the context of Europeanization idea. the most speculation tested during this booklet is that extra exchange with the ecu capability extra Europeanization (as the non-EU businesses exporting to the european have a duty to conform with ecu principles in accordance with the “No facts, No industry” succeed in provision).\n- Frost- und Frost-Tausalz-Widerstand von Betonen mit Polymerzusatz (German Edition)\n- Environmental Chemistry, Tenth Edition\n- Aluminium - ein Metall mit kurzer Geschichte, aber mit großer Zukunft: Beiträge zur Technikgeschichte (7) (German Edition)\n- Nanocoatings and Ultra-Thin Films: Technologies and Applications (Woodhead Publishing Series in Metals and Surface Engineering)\n- Principles and Practice of Mixtures Toxicology\n- Catalysis for Alternative Energy Generation\nExtra info for Advanced Catalysts and Nanostructured Materials: Modern Synthetic Methods\nAdvanced Catalysts and Nanostructured Materials: Modern Synthetic Methods by William R. Moser", "domain": "chemistry", "round": 3} +{"url": "https://engagedscholarship.csuohio.edu/scichem_facpub/545/", "date": "2023-09-29T21:03:26Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233510528.86/warc/CC-MAIN-20230929190403-20230929220403-00884.warc.gz", "language_score": 0.7374032139778137, "token_count": 267, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__134793678", "lang": "en", "text": "© 2019 The Authors Recent advances in human induced pluripotent stem cell-derived cardiomyocytes (iPSCM) field offer a novel platform for modeling cardiac metabolism, heart diseases drug candidates screening and cardiac toxicity assessments. These workflows require a fully functional characterization of iPSCMs. Here we report a step by step protocol for iPSCM metabolic characterization. The described assays cover analysis of small metabolites involved in a vital metabolic pathways.\nHouse, Alisha; Fatica, Erica; Shah, Rohan; Stergar, Jared; Pearce, Ryan; and Sandlers, Yana, \"A Protocol for Metabolic Characterization of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes (iPS-CM)\" (2020). Chemistry Faculty Publications. 545.\nCreative Commons License\nThis work is licensed under a Creative Commons Attribution 4.0 International License.", "domain": "chemistry", "round": 3} +{"url": "http://www.categray.com/2018/06/", "date": "2020-07-03T13:57:26Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-29/segments/1593655882051.19/warc/CC-MAIN-20200703122347-20200703152347-00409.warc.gz", "language_score": 0.9159770011901855, "token_count": 294, "dump": "CC-MAIN-2020-29", "global_id": "webtext-fineweb__CC-MAIN-2020-29__0__164607519", "lang": "en", "text": "A recent study by Ludwig Cancer Research demonstrated that by restoring the pH of cancer cells by using baking soda (bicarbonate of soda) in the drinking water of mice, they restored the function of the cancer cells’ circadian clock. Only cancer cells which have this tick tock rhythm remain susceptible to cancer therapies.\nThis acid-mediated effect, the Ludwig researchers assert, can be reversed by sodium bicarbonate. When the researchers gave tumor-xenografted mice water that had been supplemented with sodium bicarbonate, the acidity of hypoxic patches in the tumors was neutralized. This reversal, the scientists say, was achieved by bringing mTOR1 and RHEB back into proximity with each other.\nAcidification breaks the clock by moving constituent parts away from each other. See diagram above and explanation below. Bicarbonate of soda reverses this process.\nDeprived of oxygen cancer cells survive by shifting their metabolism which creates a chain of consequences: increased acid production; dispersed perinuclear lysosomes to the periphery of the cell; separation of perinuclear-resident and peripheral-lysosome-resident signalling factors; signalling shift inhibits production of circadian clock components; collapse of circadian clock; and entry in to a quiescent cancer therapy resistant state. Bicarbonate of soda may break the first link in this chain by buffering against acidification, ultimately preserving the effectiveness of cancer therapy.", "domain": "chemistry", "round": 3} +{"url": "http://www.conferencedequebec.org/2018/12/11/a-little-molecule-inhibitor-qlt0267-targeting-integrin-linked-kinase-can-slow-breasts/", "date": "2023-12-11T05:27:23Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679103558.93/warc/CC-MAIN-20231211045204-20231211075204-00169.warc.gz", "language_score": 0.9353933930397034, "token_count": 1216, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__32470831", "lang": "en", "text": "A little molecule inhibitor (QLT0267) targeting integrin-linked kinase can slow breasts tumor growth in vivo; nevertheless, the system of action continues to be unidentified. tumor physiology through transient adjustments in pathways regarding AKT, GSK-3 and TWIST followed with the translocation from the pro-apoptotic proteins BAD and a rise in Caspase-3 activity. for 5 min. Cell pellets had been after that re-suspended in lysis buffer [150 mM NaCl, 1% NP40, 0.5% sodium deoxycholate, 2.5 mM EDTA, 0.1% SDS, mini-protease inhibitor cocktail tablets (Roche Diagnostics; Mannheim, Germany)], sheared utilizing a 25-measure needle, incubated on glaciers for 30 min, and lastly centrifuged at 10,000 for 10 min to eliminate insoluble material. Proteins concentrations had been determined in the supernatants using the Bradford Technique and around 50 g of total proteins from each test had been denatured in launching buffer (Invitrogen) by boiling for 10 min and packed onto 10% SDS-polyacrylamide gels. Protein separated by electrophoresis had been used in nitrocellulose membranes (Millipore; Bedford, MA) and obstructed for 1 hr at area heat range in Odyssey preventing buffer (Licor Biosciences; Lincoln, NBR). Membranes had been incubated at 4C right away in Odyssey preventing buffer comprising polyclonal anti-ILK, anti-AKT, anti-P-AKT, anti-pBAD, or anti–actin antibodies (1:1000 dilution; Cell Signaling Technology). Membranes had been then washed 3 x for 5 minutes 5 min Brivanib (BMS-540215) IC50 with PBS-Tween (1% v/v) and incubated with either anti-rabbit IRDYE (Rockland; Gilbertsville, PA) or anti-rabbit Alexa 680 (Invitrogen, Molecular Probes; Burlington, ON) at 1:10,000 for 1 Brivanib (BMS-540215) IC50 hr at space temperature. Signals had been recognized using the Odyssey Infrared Recognition System and connected software program (Odyssey v1.2; Licor). The research had been completed at least 3 x and representative immunoblots are demonstrated. Immunofluorescence Cells cultivated on coverslips had been rinsed with PBS (pH 7.4), fixed using 2.5% paraformaldehyde (w/v) in PBS for 20 min at room temperature and permeabilized using 0.5% Triton X-100 (v/v) in PBS for 5 min at room temperature. Coverslips had been then washed 3 x with PBS, incubated for 1 hr in 2% bovine serum albumin (BSA) (w/v) in PBS to stop nonspecific binding, cleaned 3 x in PBS, and incubated with anti-BAD and anti-BCL-xl antibodies (Santa Cruz Biotechnology Inc.; Dallas, TX) for 1 hr at space temp. All antibodies had been diluted in BSA/PBS. Coverslips had been washed 3 x for 5 min using PBS. Major antibody binding was recognized by additional incubations with anti-rabbit Alexa 546 or Alexa 488 (Molecular Probes). To make sure that there is no nonspecific antibody binding, a second antibody control coverslip was utilized for each test, where coverslips had been stained with Brivanib (BMS-540215) IC50 either Alexa 546 or Alexa 488 by itself. Nuclei had been stained using Hoechst LECT1 nuclear stain Brivanib (BMS-540215) IC50 (10 mg/ml; Molecular Probes) at 1:1000 for 5 min at area temperature. Coverslips had been rinsed once with double-distilled drinking water and installed to microscope slides utilizing a 9:1 alternative of glycerol and PBS (Surroundings Products & Chemical substances, Inc.; Allentown, PA). Pictures had been seen and captured utilizing a Leica CTR-mic UV fluorescence microscope (Wetzlar, Germany) and a DC100 camera with Open up Lab software program (Improvision; Lexington, MA). The research had been performed at least 3 x and representative immunofluorescence pictures are proven. Caspase Activation Assay Cells had been at the mercy of the Caspase-Glo 3/7 luminescent assay (Promega; Madison, WI) based on the producers instructions. Quickly, cells harvested in 96-well plates had been treated with QLT0267 or PTE automobile for 12, 24, 48 or 72 hr. At treatment endpoint, cells had been incubated with 100 l from the ready Caspase-Glo 3/7 reagent at area heat range. The plates had been covered and covered using a plate sealer as well as the items had been mixed gently utilizing a plate shaker at 300C500 RPM for 30 sec. The plates had been after that incubated at area temperature for 3 hr. Subsequently, the luminescence of every sample Brivanib (BMS-540215) IC50 was assessed using an Optima fluorescence/luminescence dish audience (BMG Labtech; Durham, NC). Luminescence data was gathered at 420C540 nm. Fresh data from treated cells was portrayed as a share of normalized to vehicle-treated handles. The studies had been performed at least 3 x and luminescence data is normally expressed as indicate values SD. Pet Studies All pet studies had been conducted relative to and accepted by.", "domain": "chemistry", "round": 3} +{"url": "https://www.metallurgical-research.org/articles/metal/abs/2020/01/metal190001/metal190001.html", "date": "2023-10-01T12:00:12Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233510888.64/warc/CC-MAIN-20231001105617-20231001135617-00810.warc.gz", "language_score": 0.8148880004882812, "token_count": 497, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__36101563", "lang": "en", "text": "Metall. Res. Technol.\nVolume 117, Number 1, 2020\n|Number of page(s)||10|\n|Published online||20 January 2020|\nThe role of chromium during austempering of ductile iron\nInstituto de Investigación en Metalurgia y Materiales, Universidad Michoacana de San Nicolás de Hidalgo,\n2 Universidad Autónoma del Estado de Hidalgo, UAEH, Pachuca, Hidalgo, México\n3 Department of Mechanical Engineering, University of Iowa, Iowa City, Iowa 52242, USA\n* e-mail: email@example.com\nAccepted: 24 December 2019\nThe present work analyzes the effect of small additions of chromium in the final structure of a commercial Austempered Ductile Iron (ADI). The study is made with emphasis on the effect of this element on the processing window. The results indicate that chromium addition decreases the stability of austenite promoting the martensitic transformation during cooling which increases the hardness and reduces the elongation. Likewise the increase in chromium addition delays the rate of transformation to ausferrite (stage I) and accelerates the stage II reaction promoting the bainite formation narrowing the optimal processing window. However, this effect is markedly reduced when the material is subjected to a long process of homogenization, prior to austempering process. The results of this work are discussed in terms of the degree of chromium segregation during solidification.\nKey words: austempered ductile iron / chromium effect / homogenization / processing window\n© EDP Sciences, 2020\nCurrent usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.\nData correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.\nInitial download of the metrics may take a while.", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/plk1-antibody-ab70695.html", "date": "2020-09-24T21:42:06Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-40/segments/1600400220495.39/warc/CC-MAIN-20200924194925-20200924224925-00052.warc.gz", "language_score": 0.8373512625694275, "token_count": 982, "dump": "CC-MAIN-2020-40", "global_id": "webtext-fineweb__CC-MAIN-2020-40__0__271254967", "lang": "en", "text": "Key features and details\n- Rabbit polyclonal to PLK1\n- Suitable for: WB, IP\n- Reacts with: Human\n- Isotype: IgG\nProduct nameAnti-PLK1 antibody\nSee all PLK1 primary antibodies\nDescriptionRabbit polyclonal to PLK1\nTested applicationsSuitable for: WB, IPmore details\nSpecies reactivityReacts with: Human\nPredicted to work with: Mouse, Rabbit, Xenopus laevis, Chimpanzee, Rhesus monkey, Gorilla, Orangutan\nSynthetic peptide corresponding to a region between residues 1 and 50 of human PLK1.\n- Hela whole cell lysate.\nStorage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.\nStorage bufferPreservative: 0.09% Sodium azide\nConstituents: 1.815% Tris, 1.764% Sodium citrate, 0.021% PBS\nConcentration information loading...\nPurityImmunogen affinity purified\nOur Abpromise guarantee covers the use of ab70695 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\n|WB||1/500 - 1/2500. Detects a band of approximately 68 kDa (predicted molecular weight: 68 kDa).|\n|IP||Use at 2-4 µg/mg of lysate.|\nFunctionSerine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of APC/C inhibitors, and the regulation of mitotic exit and cytokinesis. Required for recovery after DNA damage checkpoint and entry into mitosis. Required for kinetochore localization of BUB1B. Phosphorylates SGOL1. Required for spindle pole localization of isoform 3 of SGOL1 and plays a role in regulating its centriole cohesion function. Phosphorylates BORA, and thereby promotes the degradation of BORA. Contributes to the regulation of AURKA function. Regulates TP53 stability through phosphorylation of TOPORS.\nTissue specificityPlacenta and colon.\nSequence similaritiesBelongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.\nContains 2 POLO box domains.\nContains 1 protein kinase domain.\nDevelopmental stageAccumulates to a maximum during the G2 and M phases, declines to a nearly undetectable level following mitosis and throughout G1 phase, and then begins to accumulate again during S phase.\nmodificationsCatalytic activity is enhanced by phosphorylation of Thr-210. Phosphorylation at Thr-210 is first detected on centrosomes in the G2 phase of the cell cycle, peaks in prometaphase and gradually disappears from centrosomes during anaphase.\nAutophosphorylation and phosphorylation of Ser-137 may not be significant for the activation of PLK1 during mitosis, but may enhance catalytic activity during recovery after DNA damage checkpoint.\nUbiquitinated by the anaphase promoting complex/cyclosome (APC/C) in anaphase and following DNA damage, leading to its degradation by the proteasome. Ubiquitination is mediated via its interaction with FZR1/CDH1. Ubiquitination and subsequent degradation prevents entry into mitosis and is essential to maintain an efficient G2 DNA damage checkpoint.\nCellular localizationNucleus. Chromosome > centromere > kinetochore. Cytoplasm > cytoskeleton > centrosome. During early stages of mitosis, the phosphorylated form is detected on centrosomes and kinetochores. Localizes to the outer kinetochore. Presence of SGOL1 and interaction with the phosphorylated form of BUB1 is required for the kinetochore localization.\n- Information by UniProt\n- Cell cycle regulated protein kinase antibody\n- PLK 1 antibody\n- PLK antibody\nab70695 has been referenced in 1 publication.\n- Xiao D et al. Polo-like Kinase-1 Regulates Myc Stabilization and Activates a Feedforward Circuit Promoting Tumor Cell Survival. Mol Cell 64:493-506 (2016). PubMed: 27773673", "domain": "chemistry", "round": 3} +{"url": "https://pubmed.ncbi.nlm.nih.gov/10030801/", "date": "2023-06-04T06:56:13Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-23/segments/1685224649518.12/warc/CC-MAIN-20230604061300-20230604091300-00704.warc.gz", "language_score": 0.9284544587135315, "token_count": 365, "dump": "CC-MAIN-2023-23", "global_id": "webtext-fineweb__CC-MAIN-2023-23__0__198674604", "lang": "en", "text": "Hemorrhagic shock (HS) can cause whole body ischemia including the gastrointestinal tract. We investigated whether cells from small intestine Peyer's patches (PP) were capable of producing superoxide radical when animals underwent HS or HS followed by resuscitation (HS/RS). HS was initiated by removing 60% of the blood volume of surgically prepared guinea pigs. PP lymphoid cells were purified and stimulated with phorbol 12-myristate 13-acetate in the presence of spin trap 5-diethoxyphosphoryl-5-methyl-1-pyrroline-N-oxide (DEPMPO). Electron paramagnetic resonance spectra of PP lymphoid cells from sham-treated control, HS, and HS/RS animals produced DEPMPO radical adducts characterized as the adducts of superoxide (DEPMPO/*OOH) and hydroxyl (DEPMPO/*OH) radicals. The formation of both radical adducts was totally inhibited by superoxide dismutase or a nicotinamide adenine dinucleotide phosphate (reduced form) oxidase inhibitor, diphenyleneiodonium chloride. HS/RS increased radical adduct formation, expressed as a percentage control, by 160% and 225% for DEPMPO/*OOH, and DEPMPO/*OH, respectively. When animals were allowed to recover for 24 h post-HS/RS treatment, PP cells decreased the superoxide generation to the same level as controls. Thus, RS following HS may prime PP lymphoid cells for increased nicotinamide adenine dinucleotide phosphate (reduced form) oxidase-dependent superoxide generation, and this process may have cytotoxic and/or immunomodulatory effects on the host.", "domain": "chemistry", "round": 3} +{"url": "http://www.huliq.com/54918/international-radiocarbon-dating-experts-revisit-turin-shroud", "date": "2020-08-10T08:31:42Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-34/segments/1596439738653.47/warc/CC-MAIN-20200810072511-20200810102511-00540.warc.gz", "language_score": 0.9500433802604675, "token_count": 438, "dump": "CC-MAIN-2020-34", "global_id": "webtext-fineweb__CC-MAIN-2020-34__0__169968856", "lang": "en", "text": "Professor Christopher Ramsey, director of the Unit that showed the cloth to be medieval in 1989, was part of a team looking at a new hypothesis that could put the date much earlier.\nDr John Jackson, of the Turin Shroud Center of Colorado in the United States, put the new hypothesis forward. Dr Jackson suggests that the shroud might over time have been contaminated with carbon monoxide, which is naturally enriched in radiocarbon.\nWhat is significant in this particular hypothesis is that only a two per cent carbon contamination from carbon monoxide is needed to move the medieval radiocarbon date of the Shroud to the first century.\nHowever, initial tests show that in normal conditions there is no contamination at the level needed to alter radiocarbon dates at all. The researchers at Oxford conclude the original medieval date is still most likely to be correct, based on current evidence, but they have yet to test whether there is anything in the specific storage conditions of the shroud that might affect this conclusion.\nDr Jackson was the leader of a 30-person scientific team from the United States that conducted a five-day scientific study of the Shroud in 1978. In this collaboration, the Colorado team was responsible for preparing test samples of modern linen exposed to carbon monoxide. The Oxford laboratory was responsible for determining if contamination actually occurred in the samples using mass spectrometry.\nThe research was carried out for an hour-long documentary, Shroud of Turin, shown by BBC2 over Easter 2008. It marked the 20th anniversary of the original carbon dating completed by the Zurich, Arizona and Oxford radiocarbon laboratories when all three labs gave a consistent, medieval date for the Shroud.\nProfessor Christopher Ramsey said: ‘Further research on the Turin Shroud is certainly needed. It is important that we continue to investigate anything that might have affected the accuracy of the original radiocarbon tests. It is equally important that other experts critically assess and reinterpret all the evidence, which may point to an earlier date. Only by doing this will we be able to arrive at a coherent history of the Shroud, which takes into account and explains all the available information.’\nSource: By University Of Oxford", "domain": "chemistry", "round": 3} +{"url": "https://www.1mg.com/labs/dombivli/diagnostic-centers/lifecare-diagnostics-160/uric-acid-random-urine-2000", "date": "2018-12-13T11:11:46Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-51/segments/1544376824675.15/warc/CC-MAIN-20181213101934-20181213123434-00086.warc.gz", "language_score": 0.94889235496521, "token_count": 419, "dump": "CC-MAIN-2018-51", "global_id": "webtext-fineweb__CC-MAIN-2018-51__0__26405130", "lang": "en", "text": "Uric Acid, Random Urine\nOverview of Uric Acid, Random Urine\nWhat is Uric Acid, Random Urine?\nThis test is usually done when you have joint pain usually in the toes or other symptoms suggestive of a disease called as gout, when you have had or you are going to have chemotherapy or radiation therapy done for cancer treatment, or when you have recurrent kidney stones to assess the cause.\nWhy is Uric Acid, Random Urine done?\n- If you have joint pain especially in the toes or other symptoms suggesting gout\n- If you have recurrent kidney stones to assess the cause\n- If you have had or are going to have certain chemotherapy or radiation therapy for cancer\nPreparation for Uric Acid, Random Urine\n- No special preparation required\nSample Type for Uric Acid, Random Urine\nThe sample type collected for Uric Acid, Random Urine is: Urine\nInterpreting Uric Acid, Random Urine results\nHigher than normal uric acid in the blood is called as hyperuricemia and can be caused by over production of uric acid in the body or inability of kidneys to remove excess uric acid\n- Increased levels of uric acid can be seen in a disease called as gout or sometimes in kidney stones\n- Low levels of uric acid is much less common and is seen in liver or kidney disease, exposure to toxic compounds or Wilson’s disease\nAnswers to Patient Concerns & Frequently Asked Questions (FAQs) about Uric Acid, Random Urine\nFrequently Asked Questions about Uric Acid, Random Urine\nQ. My uric acid levels is high but I don’t have gout. What does this test result mean?\nNot everyone who has high uric acid has gout. High levels of uric acid in blood do not always lead to symptoms. This condition is called asymptomatic hyperuricemia and can be seen in people with kidney stones, family history of gout etc.", "domain": "chemistry", "round": 3} +{"url": "https://andrearobinsongroup.com/2021/06/04/alkyne-bridged-%CE%B1-conotoxin-vc1-1-potently-reverses-mechanical-allodynia-in-neuropathic-pain-models/", "date": "2023-06-08T10:59:58Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-23/segments/1685224654871.97/warc/CC-MAIN-20230608103815-20230608133815-00713.warc.gz", "language_score": 0.7275063395500183, "token_count": 750, "dump": "CC-MAIN-2023-23", "global_id": "webtext-fineweb__CC-MAIN-2023-23__0__216600819", "lang": "en", "text": "Alessia Belgi, James V. Burnley, Christopher A. MacRaild, Sandeep Chhabra, Khaled A. Elnahriry, Samuel D. Robinson, Simon G. Gooding, Han-Shen Tae, Peter Bartels, Mahsa Sadeghi, Fei-Yue Zhao, Haifeng Wei, David Spanswick, David J. Adams, Ray S. Norton, Andrea. J. Robinson\n|Published||Journal of Medicinal Chemistry|\nSeveral Conus-derived venom peptides are promising lead compounds for the management of neuropathic pain, with α-conotoxins being of particular interest. Modification of the interlocked disulfide framework of α-conotoxin Vc1.1 has been achieved using on-resin alkyne metathesis. Although introduction of a metabolically stable alkyne motif significantly disrupts backbone topography, the structural modification generates a potent and selective GABAB receptor agonist that inhibits Cav2.2 channels and exhibits dose-dependent reversal of mechanical allodynia in a behavioral rat model of neuropathic pain. The findings herein support the hypothesis that analgesia can be achieved via activation of GABABRs expressed in dorsal root ganglion (DRG) sensory neurons.\nA. Belgi, J. V. Burnley, C. A. MacRaild, S. Chhabra, K. A. Elnahriry, S. D. Robinson, S. G. Gooding, H. S. Tae, P. Bartels, M. Sadeghi, F. Y. Zhao, H. Wei, D. Spanswick, D. J. Adams, R. S. Norton, A. J. Robinson, “Alkyne-Bridged α-Conotoxin Vc1.1 Potently Reverses Mechanical Allodynia in Neuropathic Pain Models”, J. Med. Chem., 2021, 64(6), 3233-3233.\nHydrocarbons, Peptides and proteins, Organic polymers, Catalysts, Conformation\n- Minimizing Mitogenic Potency of Insulin Analogues Through Modification of a Disulfide Bond\n- Toward the stereoselective synthesis of zaragozic acid framework: A desilylation-aldol reaction approach\n- [18 F]Ethenesulfonyl Fluoride as a Practical Radiofluoride Relay Reagent\n- Bioinspired carrier-free peptide conjugated BF2-oxasmaragdyrin dye-based nano self-assemblies: a photostable NIR cancer theragnostic agent\n- Design, Development, In Vitro and Preliminary In Vivo Evaluation of a Novel Photo-Angioplasty Device: Lumi-Solve\n- BF2-Oxasmaragdyrin Nanoparticles: A Non-toxic, Photostable, Enhanced Non-radiative Decay-Assisted Efficient Photothermal Cancer Theragnostic Agent\n- Synthesis and Studies of Glucosamine Conjugated BF2 -Oxasmaragdyrin\n- Cell-Penetrating Peptide-Conjugated BF 2 -Oxasmaragdyrins as NIRF Imaging and Photothermal Agents”", "domain": "chemistry", "round": 3} +{"url": "http://bestmdf-dveri.ru/real-time-pcr/", "date": "2022-06-28T19:18:06Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-27/segments/1656103573995.30/warc/CC-MAIN-20220628173131-20220628203131-00374.warc.gz", "language_score": 0.8117384314537048, "token_count": 441, "dump": "CC-MAIN-2022-27", "global_id": "webtext-fineweb__CC-MAIN-2022-27__0__28189367", "lang": "en", "text": "In real – time PCR with dsDNA dyes the reaction is prepared as . Cachad Översätt den här sidan Discover an array of solutions to optimize, execute, and troubleshoot MIQE- compliant real – time PCR experiments. Continuous data collection enables . Design real – time PCR SYBR Green primers and TaqMan probes for quantitative PCR. This is just an introduction.\nIt explains the realtime pcr mechanism and.\nPCR instrument generates an amplification plot that represents the accumulation of product over the . Från Agilent (Stratagene) erbjuder vi ett helt produkt-program av SYBR Green baserade reagenser. Real – Time Vs Traditional PCR. Det ger dig möjligheten att . Real-time polymerase chain reaction ( real – time PCR ) is commonly used to measure gene expression.\nIt is more sensitive than microarrays in detecting small . Skickas inom 2-vardagar. The system design combines a .\nThe applications for PCR technology were further enhanced with the development of real – time PCR. Upon introduction of the reverse transcriptase enzyme to . Quantitative real – time polymerase chain reactions (qRT- PCR ) have become the method of choice for rapi sensitive, quantitative comparison of RNA transcript . Both require training and booking. Please, see below for details. Location: CCK, floor room 057.\nIllumina remains committed to providing you with high-quality support and service. Toyobo has various real – time PCR reagents showing below. The following table shows the characteristics of each product. The detailed information can be . An article discussing the many approaches to real – time PCR and the more sophisticated instruments that perform the thermal cycling steps and monitor . Real-Time Quantitative PCR or qPCR is currently the gold standard for accurate and sensitive quantification of specific nucleic acid sequences . An Applied Biosystems (LifeTech) ViiaSequence Detection System is available for real – time PCR analysis or end-point analysis of quantitative PCR or SNP . One of the primary advantages of .", "domain": "chemistry", "round": 3} +{"url": "https://spectrapure.com/products/enduro-di-high-performance-cartridge-di-mb-endi-10", "date": "2021-05-15T14:32:34Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-21/segments/1620243991370.50/warc/CC-MAIN-20210515131024-20210515161024-00213.warc.gz", "language_score": 0.8888199925422668, "token_count": 619, "dump": "CC-MAIN-2021-21", "global_id": "webtext-fineweb__CC-MAIN-2021-21__0__157728292", "lang": "en", "text": "The SpectraPure® Enduro™ DI is the latest addition to SpectraPure®’s line of High Performance and Specialty DI cartridges. With a longer lifespan than the legacy mixed-bed or SilicaBuster™ DI cartridges, the Enduro™ DI spends more time producing water at ultra pure levels (18.2 megohms) before dropping off when resins become depleted.\nTypical mixed-bed DI cartridges can produce ultra-pure water initially, but after a short period of usage the resin’s maximum removal levels start to diminish, until with continued usage, purity will finally trend below acceptable levels and the cartridge is considered “exhausted”. The Enduro™ DI performance curve is flatter at the top, not dropping downward until much later in the cartridge's life, spending the majority of it's lifespan at maximum removal levels and with very little time at reduced levels prior to cartridge depletion.\nWhen used in a multi-stage DI system and configured as a polishing DI stage placed downstream from a MaxCap® or Mega MaxCap® DI roughing stage, the life of the Enduro™ DI increases dramatically. This translates into cost savings with fewer replacement cartridges to buy and more ultra high-purity water production between changes.\n- Standard twist top shell, 3 inch D x 10 inch L, fits in virtually all standard 10 inch filter housings\n- Designed to produce ultra high purity (18.2 megohms) deionized water for extended periods\n- Maintains ultra high purity water production characteristics well through the life of the cartridge\n- Optimized for use as a final polishing DI stage when used in a multi-stage DI configuration\n- Removes all traces of silica, nitrates, phosphates and ionized impurities\n- Extended cartridge longevity over the legacy SilicaBuster DI or conventional mixed-bed cartridges\n- Aluminized Mylar packaging eliminates resin degradation while in storage\n- Interchangeable with Captive Purity, Kent Marine, AWI, BRS and most other residential/aquarium DI or RO/DI systems\nPLEASE NOTE: SOME RESINS DISCHARGE A STRONG ODOR AND ARE BEST HANDLED IN WELL VENTILATED AREAS WHENVER POSSIBLE\nWarning: SpectraPure® does not recommend drinking water produced from deionization (DI) as DI resins are typically not made of food grade approved material.\nAsked a question about which filters after hours and first thing the next business day got a response back, so far running 0 TDS\nSpectraPure® Enduro™ DI High Performance Cartridge\nI purchased a MaxCap UHE RO/DI unit over 5 years ago. It has worked flawlessly the entire time. The membrane is still going strong at >99% rejection. Being on a well the reduced waste water is a real plus. I’ve tried generic replacement filters, but the SpectraPure filters are the best. Well worth the extra money!", "domain": "chemistry", "round": 3} +{"url": "https://nattoral.com/products/uveblock-spf50-invisible-fluid", "date": "2022-07-01T17:11:41Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-27/segments/1656103943339.53/warc/CC-MAIN-20220701155803-20220701185803-00477.warc.gz", "language_score": 0.666645884513855, "token_count": 617, "dump": "CC-MAIN-2022-27", "global_id": "webtext-fineweb__CC-MAIN-2022-27__0__17049221", "lang": "en", "text": "UVEBLOCK SPF50+ INVISIBLE FLUID OFFER\nVery high protection fluid, Buy one & get one free\nUveblock SPF 50+ Fluid effectively protects your sensitive skin from the sun thanks to its patented SUNSTRESS PROTECT complex.\nProtect from UVB and UVA rays.\nEctoine NATURAL ASSET\nProtects cells from damage caused by UV radiation.\nExtract of Sophora Japonica flower\nCombats oxidative stress caused by UV and infrared radiation.\nAQUA (WATER), ETHYLHEXYL METHOXY-CINNAMATE, ISODECYL NEOPENTANOATE, METHYLENE BIS-BENZOTRIAZOLYL TETRAMETHYLBUTYLPHENOL [NANO], PROPANEDIOL, BUTYL METHOXYDIBENZOYL- METHANE, DIISOPROPYL SEBACATE, ETHYLHEXYL SALICYLATE, TITANIUM DIOXIDE [NANO], DIETHYLAMINO HYDROXYBENZOYL HEXYL BENZOATE, ETHYLHEXYL TRIAZONE, TRIETHYLHEXANOIN, DIISOPROPYL ADIPATE, POTASSIUM CETYL PHOSPHATE, CETEARYL ALCOHOL, GLYCERIN, GLYCERYL STEARATE, DECYL GLUCOSIDE, HYDROXYETHYL ACRYLATE/SODIUM ACRYLOYLDIMETHYL TAURATE COPOLYMER, SILICA, ISOHEXADECANE, ETHYLHEXYLGLYCERIN, TOCOPHERYL ACETATE, VP/HEXADECENE COPOLYMER, CAPRYLYL GLYCOL, CHLORPHENESIN, XANTHAN GUM, PEG-40 CASTOR OIL, DIMETHICONE, SODIUM CETEARYL SULFATE, POLYSORBATE 60, ECTOIN, O-CYMEN-5-OL, CAPRYLHYDROXAMIC ACID, PROPYLENE GLYCOL, SORBITAN ISOSTEARATE, SOPHORA JAPONICA FLOWER EXTRACT\nHow to use\nOn your face and neck\nUse Uveblock SPF50+ Fluid on your face and neck a few minutes before exposing yourself to the sun.\nThis product offers quick absorption, without the white marks, and leaves your skin feeling pleasantly refreshed. Its tinted format gives you a radiant complexion and naturally unifies your skin tone.\nReapply sun protection frequently or after swimming, sweating or using a towel.", "domain": "chemistry", "round": 3} +{"url": "https://gcffamily.org/2022/what-you-should-know-about-glutamine-as-muscle-supplements.html", "date": "2023-12-10T20:20:50Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679102637.84/warc/CC-MAIN-20231210190744-20231210220744-00558.warc.gz", "language_score": 0.9318034052848816, "token_count": 622, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__202981776", "lang": "en", "text": "Glutamine is definitely an amino corrosive normally found in the necessary protein of each and every solitary living existence kind. It is actually categorized as a semi-fundamental or restrictively fundamental amino corrosive ever since the system can blend all of the glutamine it requires. It is probably the 20 proteins hereditarily coded inside the standard. It has an area chain which is an amine manufactured by supplanting glutamic corrosive’s part-sequence hydroxyl with the amine utilitarian event. It is then considered as the amide of glutamic corrosive with codons CAA and CAG. You can find also situations when our bodies could not orchestrate that will create ample measures of glutamine and requires the usage of supplements. Quite a few clinical professionals take into account glutamine as a significant amino corrosive particularly in metabolic pressure circumstances and events for example, malignant progress damage and pollution.\nThere are tons of capabilities by glutamine which very assist the body get accustomed to bodily strain and ailment. Generally individuals take somewhere in the range of 5 to 10 gr of glutamine daily. Even though our bodies normally delivers the amino corrosive it might similarly be located in lots of meats, foods produced through the terrain like seafood, chicken eggs, whole milk, beans and green spinach which individuals take in all the time. There are several biochemical aspects of glutamine as an example, being a substrate for DNA merge. It likewise presumes a significant job in protein combo stuffing in as being a gasoline hotspot for your cerebrum. D-Bal Max really is moreover an inhibitor of cortisol-incited protein catabolism, stuffing in being a crucial gasoline hotspot for enterocytes. These are generally great skinny folks manual tissue that collection the inward tiny gastrointestinal system in fact it is additionally a forerunner for quick partitioning risk-free cellular material, managing corrosive bottom parity within the renal system by way of the roll-out of ammonium and battling the spread out of microbes and other dangerous operators.\nGlutamine is moreover referred to as a nutraceutical since it highlights each healthful and wellbeing positive aspects. The amino corrosive guides in gastrointestinal potential by promoting enterocytes that range and ensures the small digestive tract. A part of the extra gastrointestinal positive aspects that glutamine may give would keep up to date gut limit work, helping mobile expansion and splitting up inside the digestion internal organs. It decreases septic dismalness equally as lowering the symptoms of IBS or fractious entrails ailment. Glutamine features a greater digestive tract removal level contrasted with some other aminos and brings about progressively persuasive purging attributes. Glutamine might be immediately altered above into glutamic corrosive which should go about as being an antecedent on the synapse GABA or gamma amino butyric corrosive. It can be additionally seen as an excitatory synapse. Glutamine viably techniques smelling salts to the liver transforming it in a much less unsafe construction, urea which can be then released by the renal system to lower hazardous effects.", "domain": "chemistry", "round": 3} +{"url": "http://onlinelibrary.wiley.com/doi/10.1002/tox.21872/full", "date": "2017-01-22T04:57:52Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-04/segments/1484560281332.92/warc/CC-MAIN-20170116095121-00382-ip-10-171-10-70.ec2.internal.warc.gz", "language_score": 0.918063223361969, "token_count": 277, "dump": "CC-MAIN-2017-04", "global_id": "webtext-fineweb__CC-MAIN-2017-04__0__200190454", "lang": "en", "text": "It has been demonstrated that the organic damages of animals can be caused by exposure to lanthanide oxides or compounds. However, the molecular mechanism of CeCl3-induced kidney injury remains unclear. In this study, the mechanism of nephric damage in mice induced by an intragastric administration of CeCl3 was investigated. The results showed that Ce3+ was accumulated in the kidney, which in turn led to oxidative stress, severe nephric inflammation, and dysfunction in mice. Furthermore, CeCl3 activated nucleic factor κB, which in turn increased the expression levels of tumor necrosis factor α, macrophage migration inhibitory factor, interleukin-2, interleukin-4, interleukin-6, interleukin-8, interleukin-10, interleukin-18, interleukin-1β, cross-reaction protein, transforming growth factor-β, interferon-γ, and CYP1A1, while suppressed heat shock protein 70 expression. These findings implied that Ce3+-induced kidney injury of mice might be associated with oxidative stress, alteration of inflammatory cytokine expression, and reduction of detoxification of CeCl3. © 2013 Wiley Periodicals, Inc. Environ Toxicol 29: 1420–1427, 2014.", "domain": "chemistry", "round": 3} +{"url": "https://www.mysciencework.com/publication/show/76916d5fc453140eb99b85cab1f02f66", "date": "2017-04-30T09:19:18Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-17/segments/1492917124478.77/warc/CC-MAIN-20170423031204-00264-ip-10-145-167-34.ec2.internal.warc.gz", "language_score": 0.7379550933837891, "token_count": 334, "dump": "CC-MAIN-2017-17", "global_id": "webtext-fineweb__CC-MAIN-2017-17__0__304976624", "lang": "en", "text": "Abstract 1′-[4-[1-(4-Fluorophenyl)-1 H-indol-3-yl]-1-butyl]spiro[isobenzofuran-1(3H),4′-piperidine] (Lu 28-179) or Siramesine is a σ-ligand with high specificity for σ 2-sites, has been tritiated to directly label these sites in brain. [ 3H]Lu 28-179 bound in a saturable manner to homogenates prepared from rat brain or human cortices with high affinity ( K d=2.2 and 1.1 nM, respectively) and moderate capacity ( B max=50±12 and 26±3 fmol mg tissue −1, respectively). The rank order of affinity for [ 3H]Lu 28-179 binding to homogenates from human and rat brain was: Lu 28-179>ifenprodil=haloperidol>1,3-di(2-tolyl)-guanidine (DTG)>(−)pentazocine≫(+)pentazocine. Using in vitro receptor autoradiography to rat brain sections [ 3H]Lu 28-179 binding was shown to be most predominant in the cerebral cortex, piriform cortex, hippocampal formation (CA1–CA3 and dentate gyrus), superior colliculus, molecular layer of the cerebellar cortex and locus coeruleus. Overall, these data are consistent with [ 3H]Lu 28-179 labelling a σ 2-like binding site.", "domain": "chemistry", "round": 3} +{"url": "https://exosome-rna.com/noninvasive-imaging-of-radiolabeled-exosome-mimetic-nanovesicle/", "date": "2024-02-28T16:25:32Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707947474737.17/warc/CC-MAIN-20240228143955-20240228173955-00267.warc.gz", "language_score": 0.9288703799247742, "token_count": 549, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__82085413", "lang": "en", "text": "Exosomes known as nano-sized extracellular vesicles attracted recent interests due to their potential usefulness in drug delivery. Amid remarkable advances in biomedical applications of exosomes, it is crucial to understand in vivo distribution and behavior of exosomes. Here, researchers from Seoul National University College of Medicine developed a simple method for radiolabeling of macrophage-derived exosome-mimetic nanovesicles (ENVs) with (99m)Tc-HMPAO under physiologic conditions and monitored in vivo distribution of (99m)Tc-HMPAO-ENVs using SPECT/CT in living mice. ENVs were produced from the mouse RAW264.7 macrophage cell line and labeled with (99m)Tc-HMPAO for 1 hr incubation, followed by removal of free (99m)Tc-HMPAO. SPECT/CT images were serially acquired after intravenous injection to BALB/c mouse. When ENVs were labeled with (99m)Tc-HMPAO, the radiochemical purity of (99m)Tc-HMPAO-ENVs was higher than 90% and the expression of exosome specific protein (CD63) did not change in (99m)Tc-HMPAO-ENVs. (99m)Tc-HMPAO-ENVs showed high serum stability (90%) which was similar to that in phosphate buffered saline until 5 hr. SPECT/CT images of the mice injected with (99m)Tc-HMPAO-ENVs exhibited higher uptake in liver and no uptake in brain, whereas mice injected with (99m)Tc-HMPAO showed high brain uptake until 5 hr. This noninvasive imaging of radiolabeled-ENVs promises better understanding of the in vivo behavior of exosomes for upcoming biomedical application.\nIn vivo SPECT/CT images of 99mTc-HMPAO-ENVs injected in mice.\nAfter intravenous injection of 99mTc-HMPAO-ENVs or 99mTc-HMPAO, SPECT/CT images were acquired at 30 min, 3 hr, and 5 hr in BALB/c mice. (a) The SPECT/CT imaging showed the significantly intense uptake of 99mTc-HMPAO-ENVs in the liver and radioactivity in the salivary glands and intestine until 5 hr. (b) In contrast, high brain uptake and the delayed salivary glands uptake were observed in 99mTc-HMPAO-injected mouse group.", "domain": "chemistry", "round": 3} +{"url": "https://www.gardenofficial.com/en/product/micellar-water-one-500-ml/", "date": "2020-01-29T11:05:32Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-05/segments/1579251796127.92/warc/CC-MAIN-20200129102701-20200129132701-00350.warc.gz", "language_score": 0.7780024409294128, "token_count": 345, "dump": "CC-MAIN-2020-05", "global_id": "webtext-fineweb__CC-MAIN-2020-05__0__118934702", "lang": "en", "text": "Micellar all-in-one cleanser water is an effective yet gentle to skin product, that removes makeup, cleanses and tones the skin, without the need for rinsing. Micellar water uses very gentle but effective cleansing agents, powerful enough to remove dirt, oil and makeup without harsh rubbing, leaving skin perfectly clean, hydrated and refreshed without drying. Micellar water is especially suitable for all types of sensitive skin.\nDERMATOLOGICALLY AND OPHTHALMOLOGICALLY TESTED. PARABENS FREE\nINGREDIENTS: AQUA, PROPYLENE GLYCOL, PEG-7 GLYCERYL COCOATE, PPG-26-BUTETH-26, PEG-40 HYDROGENATED CASTOR OIL, SODIUM LAUROYL SARCOSINATE, PHENOXYETHANOL, SODIUM BENZOATE, HYDROXYETHYLCELLULOSE, PRUNUS AMYGDALUS DULCIS SEED EXTRACT, ALOE BARBADENSIS LEAF JUICE, PANTHENOL, PEG-12 DIMETHICONE, ZINC ASPARTATE, COPPER ASPARTATE, MAGNESIUM ASPARTATE, MANGANESE ASPARTATE, TETRASODIUM EDTA\nSoak a cotton wool ball with micellar water and sweep across your whole face, paying special attention to the eye and lip area if you are removing makeup. There is no need to rinse afterwards. Just apply a suitable serum or moisturiser to your skin.", "domain": "chemistry", "round": 3} +{"url": "https://ndclist.com/ndc/77892-0005", "date": "2020-09-24T03:09:14Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-40/segments/1600400213006.47/warc/CC-MAIN-20200924002749-20200924032749-00324.warc.gz", "language_score": 0.8257890939712524, "token_count": 362, "dump": "CC-MAIN-2020-40", "global_id": "webtext-fineweb__CC-MAIN-2020-40__0__203527272", "lang": "en", "text": "The product labeling information includes all published material associated to a drug. Product labeling documents include information like generic names, active ingredients, ingredient strength dosage, routes of administration, appearance, usage, warnings, inactive ingredients, etc.\nOtc - Active Ingredient\nAlcohol (45%), Isopropyl Alcohol (30%), Benzalkonium Chloride (0,13%) (w/w)\nOtc - Purpose\nUsed for hand and skin cleaning. Open the label and take one. Gently wipe your hands with an antibacterial wipe. It does not require rinsing after use.\nIndications & Usage\nIt provides a practical cleaning without using water and soap when necessary. It helps reduce bacteria that potentially can cause disease. For use when soap and water are not available.\nFor external use only. Flammable, keep away from fire and flame.\nOtc - Do Not Use\nDo not use on open wounds and in children less than 2 months of age\nOtc - When Using\nKeep out of eyes, ears, and mouth. In case of contact with eyes, rinse eyes throughly with water.\nOtc - Stop Use\nIf irritation and redness develops and persist and in case of poisoning stop use and ask a doctor. Symptoms of Poisoning are dizziness, loss of consciousness and speech disorder.\nOtc - Keep Out Of Reach Of Children\nKeep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away.\nAqua, Glycerine, Parfum, D-Panthenol, Tocopheryl Acetate\nStore between 15-30 ºC. Avoid freezing and excessive heat above 40ºC\n* Please review the disclaimer below.", "domain": "chemistry", "round": 3} +{"url": "https://pubmed.ncbi.nlm.nih.gov/19996458/", "date": "2021-01-22T23:39:07Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-04/segments/1610703531429.49/warc/CC-MAIN-20210122210653-20210123000653-00610.warc.gz", "language_score": 0.9171434640884399, "token_count": 303, "dump": "CC-MAIN-2021-04", "global_id": "webtext-fineweb__CC-MAIN-2021-04__0__175011092", "lang": "en", "text": "Phosphoserine- and phosphothreonine-directed phosphatases display remarkable substrate specificity, yet the sites that they dephosphorylate show little similarity in amino acid sequence. Studies reveal that docking interactions are key for the recognition of substrates and regulators by two conserved phosphatases, protein phosphatase 1 (PP1) and the Ca2+-calmodulin-dependent phosphatase calcineurin. In each case, a small degenerate sequence motif in the interacting protein directs low-affinity binding to a docking surface on the phosphatase that is distinct from the active site; several such interactions combine to confer overall binding specificity. Some docking surfaces are conserved, such as a hydrophobic groove on a face opposite the active site that serves as a major recognition surface for the \"RVxF\" motif of proteins that interact with PP1 and the \"PxIxIT\" motif of substrates of calcineurin. Secondary motifs combine with this primary targeting sequence to specify phosphatase binding. A comprehensive interactome for mammalian PP1 was described, analysis of which defines several PP1-binding motifs. Studies of \"LxVP,\" a secondary calcineurin-binding sequence, establish that this motif is a conserved feature of calcineurin substrates and that the immunosuppressants FK506 and cyclosporin A inhibit the phosphatase by interfering with LxVP-mediated docking.", "domain": "chemistry", "round": 3} +{"url": "https://ckz.kncv.nl/ckz-detailpagina/405/de-wetenschap-achter-verf", "date": "2023-12-11T02:55:59Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679103464.86/warc/CC-MAIN-20231211013452-20231211043452-00362.warc.gz", "language_score": 0.8748574256896973, "token_count": 665, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__303619091", "lang": "en", "text": "Avondlezing door dr. Hanne van der Kooij en dr. Slav Semerdzhiev (Wageningen University) georganiseerd door de Chemische Kring Zwolle.\nDrying and aging coatings exhibit a wealth of complex yet fascinating phenomena. Visualizing the internal dynamics governing these phenomena is, however, intrinsically difficult because the dynamics are typically heterogeneous and span a wide range of time scales. Moreover, the high opacity of commercially relevant paints precludes conventional imaging techniques from reaching deep inside the film layers. To address these challenges, we use a novel microscopy technique, Laser Speckle Imaging (LSI), as a versatile and quantitative tool to elucidate the hidden dynamics in paints, with nanometer resolution and spanning seven decades of time. Combined with a toolbox of analysis and image processing methods, this allows a tailored investigation of virtually any coating, regardless of the chemistry, geometry and substrate. We complement our LSI results with well-established methods including light and electron microscopy. We will show how this approach enables us to shed new light on a variety of phenomena related to paints, ranging from the open time, to film formation, chemical reactions, barrier properties, edge effects, substrate interactions, coalescence, cracking and crack healing. We will thus be looking beneath the surface of coatings, to paint a new and dynamic picture of their drying.\nSlav Semerdzhiev obtained his PhD degree in 2016 at the University of Twente under the supervision of Prof. Mireille Claessens and Prof. Vinod Subramaniam, studying the physico-chemical aspects of pathological protein self-assembly. Currently he is a Postdoctoral researcher in the Physical Chemistry and Soft Matter group at Wageningen University, where he is taking a new look at the dynamics behind the drying, film formation and mechanical failure in waterborne colloidal films deploying Laser Speckle Imaging as a novel approach to unravel these rather complex phenomena. Slav’s current efforts are focused on expanding our fundamental understanding of these intricate processes and harness this advancement in knowledge to tackle emerging industrial challenges, such as the development of sustainable waterborne coatings.\nHanne van der Kooij obtained her MSc degree cum laude at Wageningen University in 2013, after a research project in the Physical Chemistry and Soft Matter group and an internship at the University of Cambridge. She is currently in the last year of her PhD at Wageningen University, where she works on understanding drying and film formation in colloidal coatings using a variety of techniques, under the supervision of Dr. Joris Sprakel. Hanne’s ambition is to contribute to a more sustainable and liveable world by providing relevant new insights based on her research. One of her main aims is to advance the development of high-quality, water-based coatings, for example by developing and applying new measurement techniques that allow her to look beneath the surface of paint films, where the human eye cannot see.\nIntroducé(e)s zijn van harte welkom.\nNadere informatie over de lezingen kunt u aanvragen via het CKZ emailadres: email@example.com.", "domain": "chemistry", "round": 3} +{"url": "https://wiredspace.wits.ac.za/items/1b2b646b-0eb5-4cd6-85c2-0833ca49d0c7", "date": "2024-02-22T13:21:10Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707947473819.62/warc/CC-MAIN-20240222125841-20240222155841-00612.warc.gz", "language_score": 0.89573073387146, "token_count": 400, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__92944340", "lang": "en", "text": "The study of cationic amphiphilic peptides with anti-cancer selective toxicity\nThe exposure of organisms to environmental stresses and pathogens results in rapid activation of a range of defensive pathways that act as part of the innate immune system. The most common innate immunity response is the activation of cationic amphiphilic peptides in response to microbial infection. Moreover, cationic amphiphilic peptides possess desirable attributes for the pharmaceutical development of cancer-selective drugs. They selectively and rapidly kill cancer cells without killing normal mammalian cells and have a broad spectrum of mechanisms of action. The aim of this exploratory study was to screen for cationic amphiphilic peptides with anti-proliferative activity that is induced by genotoxicity. GeneFishing® technology, 2-D gel analysis and bioassays were used to identify and analyse molecules induced in response to genotoxic stress in an embryonic cell line originating from the dung beetle Euoniticellus intermedius. Bioassay results revealed that the cell line has constitutive expression of probable cationic amphiphilic proteins that are further induced by camptothecin treatment. GeneFishing® and 2-D gel analysis showed changes in gene expression at both transcriptional and translational levels, respectively. Overall, the study failed to identify the involvement or induction of cationic amphiphilic peptides in response to genotoxic stress. However, gene expression analyses revealed changes in the expression of classes of proteins involved in stress response, oxidative phosphorylation, mitochondrial maintenance, protein translation, cytoskeletal proteins and immunophilins. The results show that the cell line constitutively expresses probable cationic amphiphilic peptides which are further induced by camptothecin.\nA dissertation submitted to the Faculty of Science, University of the Witwatersrand, Johannesburg, in fulfilment of the requirements for the degree of Master of Science. Johannesburg, 2014.", "domain": "chemistry", "round": 3} +{"url": "https://www.chemanalyst.com/NewsAndDeals/NewsDetails/mitsubishi-chemical-corp-eyes-on-building-worlds-largest-mma-plant-in-geismar-3426", "date": "2023-11-29T02:04:28Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100047.66/warc/CC-MAIN-20231129010302-20231129040302-00099.warc.gz", "language_score": 0.9227674007415771, "token_count": 413, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__93198264", "lang": "en", "text": "Mitsubishi Chemical Corp. Eyes on Building World’s Largest MMA Plant in Geismar\n- 10-Dec-2020 5:03 PM\n- Journalist: Francis Stokes\nThe Japanese giant Mitsubishi Chemical Corporation (MCC) is evaluating the feasibility of construction of a USD 1 billion Methyl Methacrylate (MMA) plant in Geismar, Louisiana. The 350,000 mt/year MMA manufacturing complex would employ the firm’s Alpha technology, which derives MMA from ethylene, methanol, and carbon monoxide.\nThe company has strategically chosen Louisiana as its manufacturing hub, taking into consideration the easy access to Ethylene feedstock and smooth logistics flow using the Mississippi River. The plant would be installed on a 67-acre greenfield site which the company has acquired from the synthetic rubber manufacturer Lion Elastomers. As per the governor of the state, Mr. John Bel Edwards, the plant’s construction would create around 125 new direct jobs with an average salary of USD 100,000 per annum, exclusive of other benefits. Methyl Methacrylate is the key feedstock for Acrylic-based polymers. MMA is widely used in exterior paints, adhesives, safety glazes, light displays, flat-screen monitors, building panels, clear acrylic sheets used as barriers in retail and manufacturing environments for safeguarding against virus. The products of MMA possess desirable qualities such as strength, durability, transparency, and scratch and abrasion resistance. The proposed Geismar plant is slated to start commercial operations in 2025 and it would be the largest MMA manufacturing unit in the world.\nAs per ChemAnalyst,” Through this billion-dollar project, MCC is envisioning to strengthen its global leadership in the MMA merchant market. Mitsubishi ranks among top ten US chemical exporters, as of 2019. The company’s far-sightedness is likely to serve well towards making it a leading chemicals firm across the globe.”", "domain": "chemistry", "round": 3} +{"url": "https://www.allaboutfeed.net/Home/General/2008/11/Evonik-increases-methionine-capacity-AAF002613W/", "date": "2021-01-16T05:18:39Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-04/segments/1610703500028.5/warc/CC-MAIN-20210116044418-20210116074418-00785.warc.gz", "language_score": 0.9334467053413391, "token_count": 320, "dump": "CC-MAIN-2021-04", "global_id": "webtext-fineweb__CC-MAIN-2021-04__0__128119542", "lang": "en", "text": "Evonik increases methionine capacity\nA significantly increased global demand for methionine has led Evonik\nIndustries to substantially increase DL-methionine production at its Belgian\nplant in Antwerp.\nEvonik has consistently strengthened its DL-methionine-business in recent\nyears. Methionine is an amino acid for protein supply in animal nutrition. The\nlast major step for growth was in 2006 with the commissioning of the world's\nlargest DL-methionine plant in Antwerp. The plant has a capacity of 120,000 and\nwith about € 300 million the largest investment ever in the chemistry business\nof the group.\nAt the same time, Evonik announced that the already\nexisting plant in Antwerp after an extensive modernization is back into\noperation as well. Alfred Oberholz, a member of the Board of Evonik, said:\n\"Changing eating habits and high population growth in many countries around the\nworld have increased the demand for foods of animal origin. With the continuous\nexpansion of our production capacity for DL-methionine, we are capable to match\nthis growing demand for amino acids.\"\nAntwerp is one of the major sites\nof Evonik and employs approximately 1,000 employees in the chemical business.\nExcept in Antwerp Evonik also produces DL-methionine at Wesseling in Germany and\nMobile in the US.\nTo comment, register here\nOr register to be able to comment.", "domain": "chemistry", "round": 3} +{"url": "https://link.springer.com/chapter/10.1007/978-94-009-0511-5_42", "date": "2018-09-26T03:18:37Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-39/segments/1537267163146.90/warc/CC-MAIN-20180926022052-20180926042452-00471.warc.gz", "language_score": 0.8359396457672119, "token_count": 320, "dump": "CC-MAIN-2018-39", "global_id": "webtext-fineweb__CC-MAIN-2018-39__0__137666487", "lang": "en", "text": "Evolutionary Relationships between Reaction Center Complexes with and without Cytochrome c Subunits in Purple Bacteria\nTwo types of the photosynthetic reaction center (RC) complexes are known in purple bacteria, the distribution of which depends on bacterial species (1). In one type, the RC complexes have a cytochrome subunit with four c-type hemes. The other type of RC does not have the cytochrome subunit (Fig. 1). Three demensional structures of both types of RCs have been revealed in Rhodopseudomonas viridis (2) and Rhodobacter sphaeroides (3); the former has the bound cytochrome subunit. The major difference between the two types of RC is only in the presence or absence of the cytochrome subunit and the structure of the other three peptides with pigments and quinones is similar to each other. Evolutionary relationships between the two types of RC and the role of the bound cytochrome subunit are interesting subjects in the photosynthetic electron transfer system in purple bacteria.\nKeywordsReaction Center Purple Bacterium Rhodobacter Sphaeroides Photosynthetic Reaction Center Midpoint Potential\nUnable to display preview. Download preview PDF.\n- 1.Dutton, P.L. and Prince, R.C. (1978) in The Photosynthetic Bacteria (Clayton, R.K. and Sistrom, W.R. eds.), pp. 525–570, Plenum, New YorkGoogle Scholar", "domain": "chemistry", "round": 3} +{"url": "http://chemeng.skku.edu/eng/faculty/detail.php?idx=54", "date": "2019-10-16T01:57:23Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-43/segments/1570986661296.12/warc/CC-MAIN-20191016014439-20191016041939-00432.warc.gz", "language_score": 0.6979979872703552, "token_count": 405, "dump": "CC-MAIN-2019-43", "global_id": "webtext-fineweb__CC-MAIN-2019-43__0__51170395", "lang": "en", "text": "Research Professor, KAIST (2000-2002)\nPost Doctoral Fellow, University of British Columbia (1999-2000)\nAssistant Professor, Chungnam Natl Univ. (1998-1999)\nResearch Associate, HANHWA (1986-1998)\n1. Jeong, S. W., J. M. Kim, D. H. Lee, “Effect of operating variables on synthesis of multi-walled carbon nanotubes in the fluidized beds,” CES, 134, 496-503 (2015).\n2. Kim, S. W., B. S. Koo, and D. H. Lee, “A Comparative Study of Bio-oils from Pyrolysis of Microalgae and Oil Seed Waste in a Fluidized Bed,” Bioresource Technology, 162., 96-202 (2014).\n3. Kim, D. Y., G. H. Rim, D. H. Lee, “Flow characteristics and axial bed composition according to mass ratio of binary solids in gas-solid circulating fluidized beds,” Powder Technology, 258, 344-351 (2014).\n4. Rim, GuanHe, ChoHe Jeong, Norman Epstein, John R. Grace, Yoong Lee, Sang Done Kim, Jong Wook Bae and DongHyun Lee, “Prediction of Layer Inversion Velocity in Three-Phase Fluidized Beds,” CES, 100, 91-97(2013, Aug.).\n5. Hong, Yoon Seok, Kyoung Soo Kang, Chu Sik Park, Sang Done Kim, Jong Wook Bae, Jae Wook Nam, Dong Hyun Lee, “Solid Mass Flux in a Chemical-looping Process for Hydrogen Production in a Multistage Circulating Moving Bed Reactor,” Int. J. of Hydrogen Energy, 38, 6052-6058 (2013, April).", "domain": "chemistry", "round": 3} +{"url": "https://www.itkinhibitor.com/2022/04/14/8901/", "date": "2023-09-26T13:17:16Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233510208.72/warc/CC-MAIN-20230926111439-20230926141439-00442.warc.gz", "language_score": 0.8897167444229126, "token_count": 956, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__107197568", "lang": "en", "text": "Of endoplasmic reticulum IP3 R2 reduces the number of astrocyte MCEs [17,18,24], but does not avoid elevated astrocyte MCE responses in fine processes to arousal or Ciprofloxacin (hydrochloride monohydrate) Purity & Documentation sensory stimulation , nor does it reduce the number of speedy onset MCEs evoked by nearby synaptic activity . Metabotropic glutamate 3-Methylbenzaldehyde manufacturer Receptors (mGluRs) have been one of many very first Gq-GPCR pathways located to elevate Ca2+ in astrocytes [77,92,93]. Nevertheless, these receptors are potentially additional essential for the duration of development due to the fact mature, adult astrocytes have low mGluR mRNA expression and reduced calcium responses to mGluR agonists , though this does not exclude mGluR expression and signalling within the fine processes of adult astrocytes [10,96]. A number of other GPCR pathways that evoke IP3 signalling in astrocytes are activated by neuromodulators, for instance norepinephrine and acetylcholine. These trigger astrocyte Ca2+ transients in the course of behavioural arousal states [17,24,71,72], but contribute additional to massive, delayed onset MCEs [17,24]. This suggests that rapid onset MCEs are mediated by mechanisms other than GPCR activity, including extracellular Ca2+ influx. Right here, we talk about essential pathways for rapid astrocyte Ca2+ influx through ionotropic receptors and ion channels which might be activated for the duration of neurotransmission and could play critical physiological roles in brain circuits (Figure two).Biomolecules 2021, 11, 1467 Biomolecules 2021, 11,5 of5 ofFigure Astrocyte Ca2+ pathways activated through synaptic transmission. diagram highlights Figure 2.2. Astrocyte Ca pathways activated throughout synaptic transmission. This This diagram highlights the pathways that involve extracellular Ca2+ discussed in this assessment. the pathways that involve extracellular Ca2+ influx as influx as discussed in this evaluation.2+3.1. Ionotropic Glutamate Receptors (NMDA, AMPA, and and Kainate Receptors) 3.1. Ionotropic Glutamate Receptors (NMDA, AMPA, Kainate Receptors) three.1.1. Astrocyte iGluR Expression Ionotropic glutamate receptors (iGluRs) are ligand-gated ion channels that conduct Ionotropic glutamate receptors (iGluRs) are ligand-gated ion channels that conduct cations (Na+ ,+Ca2+2+ and K+ ) when activated by synaptic glutamate (Figure 2), and this medications excitatory synaptic)transmission. Depending on their selective agonists, iGluRs andcate- me(Na , Ca and K+ when activated by synaptic glutamate (Figure 2), are this ates quickly diates into three classes, which includes -amino-3-hydroxy-5-methyl-4-isoxazolepropionic gorizedfast excitatory synaptic transmission. According to their selective agonists, iGluRs are categorized receptors, kainate receptors, and N-methyl-D-aspartate (NMDA) recepacid (AMPA) into 3 classes, like -amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid AMPA receptors are tetramers formed from four feasible subunits (GluA1tors . (AMPA) receptors, kainate receptors, and N-methyl-D-aspartate (NMDA) receptors . AMPA receptors are tetramers formed receptor, attainable subunits (GluA1GluA4), which dictate the functional properties of thefrom fourincluding their calcium GluA4), which dictate receptors also typically from the receptor, which includes their calcium permeability . Thesethe functional propertieshave speedy deactivation kinetics . Classical NMDA receptors are hetero-tetramers formedhave fast deactivation kinetics . permeability . These receptors also typically from two GluN1 subunits and two GluN2 subunits (of four possible sorts, A–D) . There are actually also less-common subu.", "domain": "chemistry", "round": 3} +{"url": "https://www.astm.org/DIGITAL_LIBRARY/STP/SOURCE_PAGES/STP1556.htm", "date": "2020-07-13T01:30:20Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-29/segments/1593657140746.69/warc/CC-MAIN-20200713002400-20200713032400-00594.warc.gz", "language_score": 0.6712238192558289, "token_count": 254, "dump": "CC-MAIN-2020-29", "global_id": "webtext-fineweb__CC-MAIN-2020-29__0__38967412", "lang": "en", "text": "| ||Format||Pages||Price|| |\n|PDF (26M)||$75||  ADD TO CART|\n|Hardcopy (shipping and handling)||$75||  ADD TO CART|\n|Hardcopy + PDF Bundle - Save 25%\n(shipping and handling)\n|$112.50||  ADD TO CART|\nCite this document\nThere is an unwavering demand for improved engine coolant technologies, including alternative freeze-depressing molecules, cooling efficiency and inhibitor chemistries. You’ll find that dynamic nature of the engine coolant industry captured in this compilation.\nData on various coolants is presented and evaluated utilizing the following standards:\nASTM D1384 Standard Test Method for Corrosion Test for Engine Coolants in Glassware\nASTM D2570 Standard Test Method for Simulated Service Corrosion Testing of Engine Coolants\nASTM D4340 Standard Test Method for Corrosion of Cast Aluminum Alloys in Engine Coolants Under Heat-Rejecting Conditions.\nImproved Aluminum Passivation for Heavy-Duty Coolants\nSandra Claeys, Serge Lievens, Jurgen De Kimpe, Paul Van de Ven", "domain": "chemistry", "round": 3} +{"url": "http://homebrew.stackexchange.com/tags/infection/new", "date": "2015-01-30T04:59:07Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2015-06/segments/1422115858583.14/warc/CC-MAIN-20150124161058-00058-ip-10-180-212-252.ec2.internal.warc.gz", "language_score": 0.9729578495025635, "token_count": 307, "dump": "CC-MAIN-2015-06", "global_id": "webtext-fineweb__CC-MAIN-2015-06__0__34729828", "lang": "en", "text": "New answers tagged infection\nIt could be an infection, although there doesn't appear to be anything wrong in the pictures. Maybe you just don't like the style?\nSour, astringent and vinegary. Definitely sounds like an infection. Lactic and acetic acid also both have higher specific gravity than water or alcohol, so that's probably why your gravity went up between weeks two and three. Lost cause? I don't know, can you stand to drink it? If not, it's certainly not going to get any better with time. What is your ...\nI've had two beers in about 100 sour on me (that weren't intended; I've also done several intentionally soured beers). It's a bummer, but not something I would throw out. Especially if it's a lemon-vinegar sour; it can be refreshing. They usually take a bit longer to bottle carbonate. Clean after use, sanitize before use and this shouldn't happen, but dust ...\nFrom http://beersmith.com/blog/2012/08/12/sour-off-flavors-in-home-brewed-beer \"Acetobacter produces acetic acid instead of lactic acid. Acetic acid is the major component in vinegar so it if you have a strong vinegar flavor in your beer it is very likely due to Acetobacter. Interestingly, acetobacter requires both the bacterial infection to occur and also ...\nTop 50 recent answers are included", "domain": "chemistry", "round": 3} +{"url": "http://www.mass-spec-capital.com/news/advion-launches-replay-flotek-biosystems-inc-bohui-group-2001-94852.html", "date": "2017-01-17T19:09:45Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-04/segments/1484560280065.57/warc/CC-MAIN-20170116095120-00220-ip-10-171-10-70.ec2.internal.warc.gz", "language_score": 0.8419261574745178, "token_count": 1435, "dump": "CC-MAIN-2017-04", "global_id": "webtext-fineweb__CC-MAIN-2017-04__0__138761942", "lang": "en", "text": "Document › Details\nAdvion. (4/1/08). \"Press Release: Advion Announces the Launch of RePlay and FloTek Products. New Microfluidic Technology for Proteomic Research\". Ithaca, NY.\n|Organisation||Advion BioSystems Inc.|\n|Organisation 2||Max Planck Institute for Biochemistry (MPIB) (Martinsried/Munich)|\n|Group||Max Planck Society for the Advancement of Science|\n|Person||Mann, Matthias (Max Planck 200808 MPI for Biochemistry)|\nAdvion BioSystems, a leading supplier of microfluidic devices for the life sciences industry, launches the latest advancements in proteomic research - the Advion RePlay and FloTek systems.\nRePlay is a new nanoLC tool that provides proteomic researchers with two complementary MS analyses from one injection. Suited for rapid identification of proteins and structural identification of post translational modifications, RePlay splits a chromatographic run into two separations directing one to the MS for analysis while simultaneously directing the other into the Capture Cartridge. Once the initial MS analysis completes, RePlay switches flow and the captured chromatographic separation is then analyzed while the nanoLC system reequilibrates thereby increasing mass spectrometer utilization time while decreasing the need for extra time and sample.\nCompatible with all nanosprayers, including MS vendor supplied sprayers, third party sprayers, pulled capillaries, and the ESI Chip, RePlay is also compatible with existing nanoLC systems and mass spectrometers.\nProteomics researchers have demonstrated that a second analysis of the same sample can improve protein and peptide coverage, increase identification of post translational modifications, and improve analytical confidence. Such repeat analysis provides more information by allowing varied analytic conditions and increased analysis time. However, the time for a single nanoLC analysis is generally 60 minutes, and many researchers do not have adequate amounts of sample or time to invest in a reanalysis. RePlay allows the researcher to obtain two analyses without a second injection saving time and sample.\nMatthias Mann, a scientific collaborator from the Max Planck Institute, states \"The RePlay device was co-developed in our laboratory, and we believe it will have a significant impact on proteomic research.\" Jennifer Busby, another RePlay user at Scripps Research, adds, \"In a proteomics service laboratory, time is money. RePlay allows me to do more in the same amount of time and thus, increase my mass spectrometer usage.\"\nThomas Kurz, President of Commerical Operations, comments on the product launch, \"Advion is positioning itself as a leader in microfluidic chemistry. There is a large need in the low flow proteomics market for a device that can improve information content of complex samples, increase expensive mass spectrometer utilization time, and maximize available sample. We have developed RePlay as an add-on product to existing nanoLC/MS systems to address all of these needs, and are pleased with the data we have seen from our users.\"\nIn addition to the RePlay device, Advion is releasing FloTek, a digital nanoflow meter. FloTek allows nanoLC users to quickly and accurately determine flow rates from their existing nanoLC system, a crucial measurement necessary for analysis. The FloTek device is intended to monitor nanoLC performance as well as assist in diagnosing nanoLC system issues. It can be used in conjunction with RePlay or as a stand alone device.\nAdvion has received patent pending status of RePlay, and is the sole supplier of this technology. Orders for the RePlay and Flotek devices should be placed with a local Advion account manager.\nAbout Advion BioSystems, Inc.\nAdvion is the scientific leader in microfluidics systems. The company's scientific knowledge base creates unique nanotechnologies delivering speed, flexibility, and exceptional data quality. Advion is the microfluidics supplier of choice for customers demanding scientific excellence that provides better synthesis, accurate mass analysis, higher yields and greater throughput. More information about the company can be found on their website at www.advion.com .\nManager of Corporate Marketing Communications\nAdvion BioSciences, Inc.\np: 1.607.266.0665 ext. 314\nRecord changed: 2016-03-19\nMore documents for Bohui (Group)\n- Advion, Inc.. (11/10/16). \"Press Release: Advion Expands Australian Reach with Accurate Mass Scientific\". Ithaca, NY....\n- Advion, Inc.. (9/27/16). \"Press Release: Advion Sells 500th Compact Mass Spec. Extends Market Leadership\". Ithaca, NY....\n- Advion, Inc.. (3/15/16). \"Press Release: Advion Launches Novel Metal Catalyst Reaction Monitoring Probe. Collaborates with Albert-Ludwigs-University of Freiburg and Files Related Patents\". Ithaca, NY....\n- Advion, Inc.. (3/9/16). \"Press Release: Advion Launches Cost-effective, Bench-top Solid Phase Peptide Synthesis and Protein Characterization Mass Spectrometer\". Ithaca, NY....\n- Advion, Inc.. (10/30/15). \"Press Release: Advion Receives BCEIA New Product Innovation Award for nano LC Ion Source\". Beijing....\n- Advion, Inc.. (10/23/15). \"Press Release: Advion Expands Chemistry Mass Spec Market Position\". Ithaca, NY....\n- Advion, Inc.. (8/17/15). \"Press Release: Simplified Compact Mass Spectrometer Software Platform for Chemists\". Ithaca, NY....\n- Advion, Inc.. (6/5/15). \"Press Release: Beijing Bohui Innovation Technology Co., Ltd. (Bohui) Agrees to Acquire Advion, Inc.\". Ithaca, NY....\n- Advion, Inc.. (6/1/15). \"Press Release: Advion Expands Its Mass Spectrometry Offering to Include Undergraduate Chemistry/Biochemistry Curriculum Content\". Ithaca, NY....\n- Advion, Inc.. (3/23/15). \"Press Release: Advion Introduces an Automated TLC-Compact Mass Spectrometry System\". Ithaca, NY....\nTo subscribe to our free, monthly mass spectrometry newsletter, please send an e-mail to email@example.com and simply fill the subject line with the word »MSC newsletter«\nTo get even more information, please take a look at our [gs] professional services offering and read the gene-sensor Product Flyer [PDF file]", "domain": "chemistry", "round": 3} +{"url": "https://www.routledge.com/Energetic-Materials-Thermophysical-Properties-Predictions-and-Experimental/Boddu-Redner/p/book/9781439835135?utm_source=crcpress.com&utm_medium=referral", "date": "2020-08-08T09:01:49Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-34/segments/1596439737319.74/warc/CC-MAIN-20200808080642-20200808110642-00568.warc.gz", "language_score": 0.8874596953392029, "token_count": 1304, "dump": "CC-MAIN-2020-34", "global_id": "webtext-fineweb__CC-MAIN-2020-34__0__139592469", "lang": "en", "text": "The development, processing, and lifecycle environmental impact analysis of energetic materials all pose various challenges and potential dangers. Because safety concerns severely limit study of these substances at most research facilities, engineers will especially appreciate a tool that strengthens understanding of the chemistry and physics involved and helps them better predict how these materials will behave when used in explosives, propellants, pyrotechnics, and other applications.\nIntegrate Cutting-Edge Research Sponsored by the U.S. Department of Defense\nEnergetic Materials: Thermophysical Properties, Predictions, and Experimental Measurements covers a variety of advanced empirical modeling and simulation tools used to explore development, performance, sensitivity, and lifecycle issues of energetic materials. Focusing on a critical component of energetic materials research— prediction of thermophysical properties—this book elucidates innovative and experimental techniques being used to:\n- Apply molecular and meso-scale modeling methodologies to measure reactivity, performance, and properties of new energetic materials\n- Gain insight into shear initiation at the particulate level\n- Better understand the fate, transport, and overall environmental impact of energetic materials\n- Evaluate the performance of new materials and assess their reaction mechanisms\nEdited by two respected U.S. Army engineers, this book highlights cutting-edge research from leaders in the energetics community. Documenting the history, applications, and environmental behavior of energetic materials, this reference is a valuable resource for anyone working to optimize their massive potential—either now or in the future.\nTable of Contents\nIntroduction: Thermophysical Properties of Explosive Materials, V.M. Boddu and P. Redner\nThe History, Chemistry, and Physics of Energetic Materials, P. Redner\nPhysical Property Prediction of Energetic Materials from Molecular Dynamics Simulation, N. Sokkalingam, J. Potoff\nPredicting the Solvation Free Energy of 1,3,5-Triamino-2,4, 6-Trinitrobenzene (TATB) in Organic Solvents, J.L. Lewin, N. Rai, K.A. Maerzke, D. Bhatt, J.I. Siepmann, A. Maiti, and L.E. Fried\nPrediction of Physicochemical Properties of Energetic Materials via EPI Suite, S. Chakka, V.M. Boddu, S.W. Maloney, and R. Damavarapu\nMechanisms and Kinetics of CL-20 Modes of Transformation via Alkali Hydrolysis and via Photolysis and Thermolysis Free Radical Reactions, M. Qasim, Y. Kholod, S. Okovytyy, O. Isayev, L. Gorb, V.M. Boddu, and J. Leszczynski\nIgnition of Metal Powder by Electrostatic Discharge, E. Beloni and E.L. Dreizin\nPhysicochemical Property Measurements on Insensitive Munitions Compounds for Environmental Applications, V.M. Boddu, K. Abburi, S.W. Maloney, and R. Damavarapu\nGroup Contribution Techniques: Predicting the Properties of nergetic Chemicals, K.G. Joback\nPrediction of Physicochemical Properties of Energetic Materials, R. K. Toghiani, H. Toghiani, S.W. Maloney, and V.M. Boddu\nSolubility of RDX, HMX, and ε-CL20 in Supercritical Carbon Dioxide, R. K. Toghiani, H. Toghiani, S.W. Maloney, and V.M. Boddu\nCombustion Behavior of Nanoenergetic Material Systems, R. Thiruvengadathan, A. Bezmelnitsyn, S. J. Apperson, D. Tappmeyer, P. Redner, W.A. Balas, S. Nicolich, D. Kapoor, K. Gangopadhyay, and S. Gangopadhyay\nDr. Veera M. Boddu is a senior research engineer with in the Environmental Processes Branch at the U.S. Army Engineer Research and Development Center, Construction Engineering Research Laboratory, Champaign, Illinois. Dr. Boddu has over 20 yrs of research experience with focus on studying thermophysical properties of explosive materials, and developing innovative technologies for waste streams from Army manufacturing facilities and training lands. Dr. Boddu also conducts research on catalytic degradation of new insensitive munitions explosives on nanomaterials. Dr. Boddu has published more than 35 peer reviewed journal articles, 10 Army technical reports, and 3 patents. Dr. Boddu received his B. S. from National Institute of Technology, Warangal, India, an M. S. from the Indian Institute of Technology, Kanpur, and a Ph.D. in Chemical Engineering from the University of Missouri at Columbia, all in Chemical Engineering. He is a registered professional engineer in the state of Missouri and a board-certified environmental engineer. He is an adjunct professor in the Nuclear Science and Engineering Institute at the University of Missouri at Columbia.\nPaul Redner is a senior chemical engineer with the Energetics Research Branch at the U.S. Army Research, Development and Engineering Command - Armament Research, Development and Engineering Center (RDECOM-ARDEC), located at Picatinny Arsenal, New Jersey. Mr. Redner has over 11 years of research and management experience, ranging from the recrystallization and processing of high explosives such as RDX to the development of nanoscale and nanostructured materials for use in both energetic and non-energetic applications. He is currently the project officer for eight programs concentrating on the development and integration of advanced materials and nanotechnologies into Army weapons systems and spends the balance of his time performing business development duties for this technology area. Mr. Redner has published 40 peer-reviewed journal articles and has presented papers at over 36 national and international meetings. Mr. Redner received his BE in Environmental Engineering and ME in Chemical Engineering from Stevens Institute of Technology, Hoboken, New Jersey. He received his MBA from New York University – Stern School of Business, New York, New York.", "domain": "chemistry", "round": 3} +{"url": "https://ebiohippo.com/products/bha11301103", "date": "2019-08-25T09:01:49Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-35/segments/1566027323246.35/warc/CC-MAIN-20190825084751-20190825110751-00001.warc.gz", "language_score": 0.808283805847168, "token_count": 651, "dump": "CC-MAIN-2019-35", "global_id": "webtext-fineweb__CC-MAIN-2019-35__0__13847103", "lang": "en", "text": "ebiohippo is a top distributor of the best and most reliable ELISA and Assay kits. We can provide a wide range of kits from well-known suppliers and brands with authentic and validated data. We provide antibodies to help you quickly identify and quantify proteins, and evaluate other necessary data for various applications in life sciences.\nAnti-EPHB4 Antibody BHA11301103\nAlternative: Ephrin type-B receptor 4|Hepatoma transmembrane kinase|Tyrosine-protein kinase TYRO11|EPHB4|HTK|MYK1|TYRO11\nSpecies: Homo Sapiens (Human)\nDelivery: Free shipping. Usually ships in 7 to 10 business days\nCategories: Primary Antibodies|Polyclonal Antibodies\nChromosome Location: 7q22.1\nImmunogen: Synthetic peptide, corresponding to amino acids 580-630 of Human EphB4.\nDescription: EphB4, also known as Htk, Myk1, Tyro11, and Mdk2, is a member of the Eph receptor family, which binds of the ephrin ligand family. Two classes of receptors exist, designated A and B, that have an extracellular domain made up of a globular domain, a cysteine-rich domain, and two fibronectin type III domains, followed by the transmembrane region and cytoplasmic region. The cytoplasmic region contains juxtamembrane motif with two tyrosines, which are the major autophosphorylation sites, along with a kinase domain, and a conserved sterile alpha motif (SAM) in the carboxyl terminus, which includes one conserved tyrosine. Ligand recognition and binding leads to activation of intrinsic kinase activity.\nTARGETWeight: 108 kDa\nPROPERTYStorage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\nPurity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).\nDesc: Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.Specificity: EphB4 (E601) polyclonal antibody detects endogenous levels of EphB4 protein.\nDescription: Western blot (WB) analysis of EphB4 (E601)pAb at 1:500 dillutionLane1:Hcc827 whole cell lysateLane2:LO2 whole cell lysateLane3:The Kidney tissue lysate of MouseLane4:The Kidney tissue lysate of Rat\nDescription: Immunohistochemistry (IHC) analyzes of EphB4 (E601) pAb in paraffin-embedded human brain tissue.", "domain": "chemistry", "round": 3} +{"url": "http://m.mzballs.com/ceramic-balls/si3n4-balls.html", "date": "2019-10-17T00:25:25Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-43/segments/1570986672431.45/warc/CC-MAIN-20191016235542-20191017023042-00312.warc.gz", "language_score": 0.8349833488464355, "token_count": 265, "dump": "CC-MAIN-2019-43", "global_id": "webtext-fineweb__CC-MAIN-2019-43__0__173866524", "lang": "en", "text": "Weight of a Si3N4 ball is less than half weight of a general steel ball with excellent physical performance. Thus, these balls are using in aerospace, high precision bearings, wind power generation, pumps, valves etc.\nCeramic balls could be separated into two types: non-oxide ceramic balls (such as silicon nitride, Si3N4 balls) and oxide ceramic balls (such as alumina and zirconia balls). Weight of a Si3N4 ceramic ball is less than half weight of a general steel ball. Besides, ceramic balls have excellent performance of corrosion resistance, antirust, wear resistance, high working temperature, electrical insulation etc. Thus, these balls are using in aerospace, high precision bearings, wind power generation, pumps, valves etc.\n0.4 mm up to 100 mm (4\")\n2C, 3C, 5C, 10C, 16C, 24C, 48C\n4 – 6 nm\nHigh temperature resistance\nAerospace, National defense, chemical industry, Metallurgical, Medical, Food, Oil plant, Electronic etc.\nMingzhen is one of the famous Ceramic Balls manufacturers and suppliers in China, providing with si3n4 balls free sample, welcome to import si3n4 balls from our factory.", "domain": "chemistry", "round": 3} +{"url": "https://saemobilus.sae.org/content/852112/", "date": "2023-02-09T11:46:25Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-06/segments/1674764499966.43/warc/CC-MAIN-20230209112510-20230209142510-00662.warc.gz", "language_score": 0.7830396890640259, "token_count": 886, "dump": "CC-MAIN-2023-06", "global_id": "webtext-fineweb__CC-MAIN-2023-06__0__164791683", "lang": "en", "text": "This content is not included in your SAE MOBILUS subscription, or you are not logged in.\nThe Importance of Friction Modifiers in the Formulation of Fuel Efficient Engine Oils\nISSN: 0148-7191, e-ISSN: 2688-3627\nPublished October 01, 1985 by SAE International in United States\nAnnotation ability available\nFuel economy benefits derived from improved engine crankcase lubricants have been well documented in the last 10 years. These benefits can be gained not only by a reduction in oil viscosity but also by addition of special friction modifier additives. These have been shown to operate by reducing the friction within the boundary regimes of the engine.\nWork has been carried out which indicates that a secondary but possibly more significant contribution can be made by friction modifiers where the hydrodynamic regime is extended to lower viscosities. As a result it may be possible to formulate finished lubricants with lowered viscosities while remaining free from wear debits. Such optimised lubricants will result in furtner fuel economy improvements.\nCitationGriffiths, D. and Smith, D., \"The Importance of Friction Modifiers in the Formulation of Fuel Efficient Engine Oils,\" SAE Technical Paper 852112, 1985, https://doi.org/10.4271/852112.\n- Screening Tests Used for Developing Fuel Efficient Engine Oils Chamberlin and Saunders The Lubrizol Corporation: ASLE 34th Annual Meeting 1979\n- Determining Friction Characteristics of Engine Oils by Engine Friction and Viscosity Measurements Dancy J.H. Marshall H.T. Oliver C.R. SAE 800365\n- Fuel Economy Lubricants in Heavy Duty Road Service Younghouse E.C. Waddey W.E. Schmidt R.P. SAE 801349\n- The Effect of Molybdenum Containing Oil Soluble Friction Modifiers on Engine Fuel Economy and Gear Oil Efficiency Greene A.B. Risdar T.J. SAE 811187\n- Oil Soluble Friction Reducers - Theory and Application Papay A.G. J. of the Amer. Soc. of Lub. Eng. 38 7 419 1982\n- The Influence of Motor Oil Viscosity and Friction Modification on Automotive Fuel Economy, C6/82 I. Mech. E. 1982 Roberts D.C. Gaskill G.P. Richard G.P.\n- Fuel Economy Improvements with Friction Modified Engine Oils in Environmental Protection Agency & Road Tests Haviland M.L. Goodwin M.C. General Motors\n- Bench Engine Testing of Low Viscosity Engine Oils Pommer W. Klamann D. Symposium on Fuel Efficient Lubricants Esslingen June 1984\n- The Relationship Between Oil Viscosity and Engine Performance - A Literature Search Stewart R.M. Selby T.W. SAE Paper 770372\n- European Valve Train Wear - Some Experience with the Volvo B20 Test Slater B.B. SAE Paper 750866\n- European Oils for Spark Ignition Engines Roux F. SAE Paper 750863\n- Viscosity Effects on Engine Wear Under High-Temperature. High-Speed Conditions McMillan M.L. Rosenberg R.C. Murphy C.K. SAE Paper 7809512\n- The Relationship of Journal Bearing Wear to Multigrade Engine Oil Viscometric Properties Stambaugh R.L. Kopko R.J. Bennett P.A. SAE Paper 770627\n- Some Relationships Between the Viscometric Properites of Motor Oils and Performance in European Engines Bell J.C. Voisey M.A. SAE Paper 770378\n- Engine Oil and Bearing Wear Longstrup T.F. Smith, M.F. Jr. SAE Paper 810330\n- The Effects of Engine Oil Viscosity and Composition on Fuel Efficiency Clevenger J.E. Carlson D.C. Kleiser W.M. SAE Paper 841369", "domain": "chemistry", "round": 3} +{"url": "https://research.unipg.it/handle/11391/1544573", "date": "2023-12-11T18:18:20Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679516047.98/warc/CC-MAIN-20231211174901-20231211204901-00344.warc.gz", "language_score": 0.9223507046699524, "token_count": 326, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__223931888", "lang": "en", "text": "Metal catalyzed polymerizations are among the most important chemical reactions, accounting for the production of about 400 million tons per year of polymeric materials, 50 % of which are polyolefins. The CIRCC research units at the University of Salerno, founded by the late Professor Adolfo Zambelli, a coworker of Giulio Natta and a pioneer in the studies of stereospecific polymerization catalysts, has a consolidated expertise in this field. Although often considered a \"mature\" area of research, olefin polymerization catalysis continues to drive great interest of both industrial and academic scientists. On the other hand, strong political and economic pressure toward the development of \"green\" and possibly biodegradable alternatives to olefin-based polymers stimulated our group to direct increasing research efforts in the area of sustainable polymers. In this perspective, we focus on the most recent work from the CIRCC research units involved in homogeneous catalysis for polymerization of a variety of monomers, with the aim to address how the concepts and the expertise developed for olefin polymerization can be applied to the development of different metal-catalyzed polymerizations and copolymerizations. Of course, although the results are discussed in the frame of the most important literature contributions, a comprehensive review of such a wide and diversified topic is out of the scope of the paper. References to reviews covering the different types of metal catalyzed polymerizations are provided in each chapter.\nFile in questo prodotto:\nNon ci sono file associati a questo prodotto.", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/recombinant-human-gcsf-receptor-protein-ab168697.html", "date": "2018-09-21T02:25:06Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-39/segments/1537267156724.6/warc/CC-MAIN-20180921013907-20180921034307-00310.warc.gz", "language_score": 0.8635602593421936, "token_count": 559, "dump": "CC-MAIN-2018-39", "global_id": "webtext-fineweb__CC-MAIN-2018-39__0__51207438", "lang": "en", "text": "The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\nMeasured by its ability to inhibit the GCSF-induced proliferation of NFS-60 mouse myeloid cells. The ED50 for this effect is typically 0.02-2 µg/ml in the presence of 0.125 ng/ml of recombinant Human GCSF.\n< 1.000 Eu/µg\n>95% by SDS-PAGE . Lyophilized from 0.22 µm filtered solution.\nConcentration information loading...\nPreparation and Storage\nStability and Storage\nShipped at 4°C. Store at 4°C prior to reconstitution. Store at -80°C. Avoid freeze / thaw cycle.\npH: 7.40 Constituents: 95% PBS, 5% Trehalose Note: 5-10% trehalose is commonly used for freeze drying, and after reconstitution, the trehalose is mostly about 3-5%.\nThis product is an active protein and may elicit a biological response in vivo, handle with caution.\nIt is recommended to reconstitute the lyophilized protein in sterile deionized water to a final concentration of 250 ug/ml. Solubilize for 30 to 60 minutes at room temperature with occasional gentle mixing. Carrier protein (0.1% HSA or BSA) is strongly recommended for further dilution and long term storage.\nReceptor for granulocyte colony-stimulating factor (CSF3), essential for granulocytic maturation. Plays a crucial role in the proliferation, differientation and survival of cells along the neutrophilic lineage. In addition it may function in some adhesion or recognition events at the cell surface.\nOne or several isoforms have been found in myelogenous leukemia cell line KG-1, leukemia U-937 cell line, in bone marrow cells, placenta, and peripheral blood granulocytes. Isoform GCSFR-2 is found only in leukemia U-937 cells. Isoform GCSFR-3 is highly expressed in placenta.\nInvolvement in disease\nBelongs to the type I cytokine receptor family. Type 2 subfamily. Contains 5 fibronectin type-III domains. Contains 1 Ig-like C2-type (immunoglobulin-like) domain.\nThe WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. The box 1 motif is required for JAK interaction and/or activation.", "domain": "chemistry", "round": 3} +{"url": "https://mbltech.ru/radiometric-dating-research-paper-3287.html", "date": "2020-12-05T04:58:14Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-50/segments/1606141746320.91/warc/CC-MAIN-20201205044004-20201205074004-00141.warc.gz", "language_score": 0.9732340574264526, "token_count": 308, "dump": "CC-MAIN-2020-50", "global_id": "webtext-fineweb__CC-MAIN-2020-50__0__6107136", "lang": "en", "text": "Radiometric dating research paper\nThe radiocarbon dating method is based on the fact that radiocarbon is constantly being created in the atmosphere by the interaction of cosmic rays with atmospheric nitrogen.\nResearch has been ongoing since the 1960s to determine what the proportion of in the atmosphere has been over the past fifty thousand years.\nThe resulting data, in the form of a calibration curve, is now used to convert a given measurement of radiocarbon in a sample into an estimate of the sample's calendar age.\nEven for the first investigation, there was a possibility of using radiocarbon dating to determine the age of the linen from which the shroud was woven.\nThe size of the sample then required, however, was ~500cm, which would clearly have resulted in an unacceptable amount of damage, and it was not until the development in the 1970s of small gas-counters and accelerator-mass-spectrometry techniques (AMS), requiring samples of only a few square centimetres, that radiocarbon dating of the shroud became a real possibility. The shroud was separated from the backing cloth along its bottom left-hand edge and a strip (~10 mm x 70 mm) was cut from just above the place where a sample was previously removed in 1973 for examination.\nThis was done by observing the relative age sequence of rock units in a given area and determining, from stratigraphic relations, which rock units are younger, which are older, and what assemblages of fossils are contained in each unit.", "domain": "chemistry", "round": 3} +{"url": "http://www.morainetownshipdems.org/2016/03/10/oxalate-is-an-end-item-of-glycolate-fat-burning-capacity-thats/", "date": "2024-04-14T07:10:21Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712296816875.61/warc/CC-MAIN-20240414064633-20240414094633-00228.warc.gz", "language_score": 0.924060583114624, "token_count": 965, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__118086443", "lang": "en", "text": "Oxalate is an end item of glycolate fat burning capacity that’s primarily excreted with the kidney and may be the most typical constituent of kidney rocks. to the top of cell membrane decreases viability decreases antioxidative enzymes and induces apoptosis in renal cells [5-10]. Although a number of cellular resources of reactive air species (ROS) have already been confirmed NADPH oxidase provides been proven to modulate redox position from the kidney during renal illnesses . Nevertheless the potential function of NADPH oxidase in hyperoxaluria-induced kidney rock formation isn’t well known until recently. We were the first to demonstrate in 2004 that oxalate induces ROS generation through the activation of NADPH oxidase which plays a major role in renal proximal tubular injury . Following completion of our study Umekawa et al exhibited in 2005 that involvement of NADPH Rabbit polyclonal to TGFB2. oxidase in oxalate and calcium oxalate monohydrate crystal induced ROS generation in rat kidney epithelial cells. Since then research has been focused on controlling 64790-15-4 IC50 the NADPH oxidase-mediated cell injury to prevent hyperoxaluria-induced kidney stone formation [14-18]. The NADPH oxidase is a multicomponent enzyme complex that consists of the membrane-bound cytochrome b558 which contains gp91phox and p22phox the cytosolic regulatory subunits p47phox and p67phox and the small guanosine triphosphate-binding protein Rac. On stimulation the cytosolic subunits translocate to the membrane and associate with cytochrome b558 resulting in activation of the NADPH oxidase . Formation and activation of NADPH oxidase allow electrons to be passed from the cofactor NADPH to molecular oxygen producing superoxide radicals . In view of the fact that NADPH oxidase activity is usually noticeably increased in renal 64790-15-4 IC50 cells exposed to oxalate focusing on mechanisms leading to NADPH oxidase 64790-15-4 IC50 activation could unveil further molecular details involved in oxalate-induced renal injury. Rac1 a small G protein is a signaling molecule that coordinates the intracellular transduction pathways which activate NADPH oxidase . Once activated Rac1 migrates from the cytosol to the plasma membrane where its attachment favors assembly of the various NADPH oxidase subunits [22 23 Even though many investigations including latest animal models have got implicated Rac1 being a central mediator in cardiac and vascular hypertrophy and leukocyte migration [24-27] its function in oxalate-induced renal cell damage isn’t known. We previously demonstrated that oxalate induces oxidative damage via PKC alpha and delta-mediated activation of NADPH oxidase in renal proximal tubular epithelial cells . Nevertheless no direct proof is certainly on how NADPH oxidase is certainly turned on by oxalate in renal tubular epithelial cells. To look for the signaling element downstream of PKC that control NADPH oxidase activation we centered on Rac1. We motivated the influence of Rac1 on oxalate-induced NADPH oxidase activation ROS era; and looked into the function of Rac1 in oxalate-induced cell damage in renal epithelial cells. Components and methods Components DMEM was bought from Invitrogen (Gaithersburg MD) Lucigenin NADPH as well as the anti-Na/K-ATPase antibody was extracted from Sigma (St. Louis MO). NSC23766 and rottlerin from EMD (Gibbstown NJ). PKC 64790-15-4 IC50 α inhibitor peptide and anti-Rac1 antibody had been extracted from Santa Cruz Biotechnology (Santa Cruz CA). Cell lifestyle Cultures of LLC-PK1 cells an epithelial cell series from pig kidney with properties of proximal tubular cells (CRL 1392 ATCC Rockville MD) had been preserved as sub confluent monolayers in 75-cm2 Falcon T-flasks in DMEM formulated with 10% fetal bovine serum streptomycin (0.20 mg/ml) and penicillin (1.0 × 102 IU/ml) pH 7.4 at 37°C within a 5% CO2-95% surroundings atmosphere. Experiments had been completed with serum- and pyruvate-free MEM. Oxalate was ready being a share option of 10 mM sodium oxalate in regular sterile PBS and diluting it to 0.75 mM within the medium.", "domain": "chemistry", "round": 3} +{"url": "http://www.myotcstore.com/store/p/35650-ChapStick-Classic-Lip-Balm-SPF-4-Strawberry-0-15-oz-24-ea.aspx", "date": "2014-09-17T01:33:34Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2014-41/segments/1410657120446.62/warc/CC-MAIN-20140914011200-00108-ip-10-196-40-205.us-west-1.compute.internal.warc.gz", "language_score": 0.6936103105545044, "token_count": 264, "dump": "CC-MAIN-2014-41", "global_id": "webtext-fineweb__CC-MAIN-2014-41__0__129005170", "lang": "en", "text": "Padimate O (1.5%) (Sunscreen), White Petrolatum (44%) (Skin Protectant).\nArachadyl Propionate, Camphor, Carnauba (Copernicia Cerifera) Wax, Cetyl Alcohol, D&C Red 6 Barium Lake (CI 15850), Fragrance, Isopropyl Lanolate, Isopropyl Myristate, Lanolin, Lemon (Citrus Medica Limonium) Oil, Light Mineral Oil, Maltol, Methylparaben, Octyldodecanol, Paraffin, Phenyl Trimethicone, Propylparaben, Saccharin, White Wax.\n- For external use only.\n- When using this product keep out of eyes.\n- Rinse with water to remove.\n- Stop use and ask a doctor if rash or irritation develops and lasts, or if condition worsens or does not improve within 7 days.\n- Keep out of reach of children.\n- If swallowed, get medical help or contact a poison control center right away.\nSun Alert:Limiting sun exposure, wearing protective clothing, and using sunscreens may reduce the risks of skin again, skin cancer, and other harmful effects of the sun.", "domain": "chemistry", "round": 3} +{"url": "http://wikien4.appspot.com/wiki/SH-053-R-CH3-2%E2%80%B2F", "date": "2019-03-23T21:38:14Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-13/segments/1552912203021.14/warc/CC-MAIN-20190323201804-20190323223804-00511.warc.gz", "language_score": 0.7336234450340271, "token_count": 363, "dump": "CC-MAIN-2019-13", "global_id": "webtext-fineweb__CC-MAIN-2019-13__0__10537520", "lang": "en", "text": "SH-053-R-CH3-2′F is a drug used in scientific research which is a benzodiazepine derivative. It produces some of de same effects as oder benzodiazepines, but is much more subtype-sewective dan most oder drugs of dis cwass, having high sewectivity, binding affinity and efficacy at de α5 subtype of de GABAA receptor. This gives much tighter controw of de effects produced, and so whiwe SH-053-R-CH3-2′F retains sedative and anxiowytic effects, it does not cause ataxia at moderate doses. SH-053-R-CH3-2′F awso bwocks de nootropic effects of de α5-sewective inverse agonistPWZ-029, so amnesia is awso a wikewy side effect.\nRepwacement of de ester function by an amide, reawized in anawogs such as MP-III-022 and GL-II-73, improves sewectivity, efficacy and kinetic behavior.\n^Cook JM, Li G, Poe M, Savic M, Sibiwwe E. Treatment of cognitive and mood symptoms in neurodegenerative and neuropsychiatric disorders wif awpha5-containing gabaa receptor agonists. Patent appwication CA3016491\n^Prevot TD, et aw. Novew Benzodiazepine-Like Ligands wif Various Anxiowytic, Antidepressant, or Pro-Cognitive Profiwes. Mowecuwar Neuropsychiatry, 2019; 1. doi:10.1159/000496086", "domain": "chemistry", "round": 3} +{"url": "https://www.hycultbiotech.com/product/trem-1-mouse-mab-l5-b8-fitc/", "date": "2023-12-08T03:24:59Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100710.22/warc/CC-MAIN-20231208013411-20231208043411-00104.warc.gz", "language_score": 0.8881648778915405, "token_count": 338, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__25732231", "lang": "en", "text": "Calculate your ELISA data easily\nWith the ELISA calculator you can easily calculate ELISA data. Assayfit Pro helps to perform curve fitting. The calculator generates advanced reports, fit graph, fit parameters and goodness of fit are shown.\nLatest Hycult Biotech news\n- Discover Cross-Reactive Complement ELISA for NHP ResearchBridging Human and NHP Complement Research. At Hycult Biotech, we understand the importance of testing therapeutic agents on non-human primates (NHP) samples in order to get approval to enter clinical phases. That is why we have committed to the following initiative: Testing our existing complement ELISA assays for NHP research. Why Non Human Primate Samples… Read more: Discover Cross-Reactive Complement ELISA for NHP Research\n- New Human Complement Pathway AssaysWe are very proud of our newly developed human classical and alternative complement pathway assays. They are produced in response to a growing demand for quantitative investigation of complement inhibitors or regulators at lower sample dilutions. This development aims to address the issue of false negative results, enabling more accurate and reliable analysis of complement… Read more: New Human Complement Pathway Assays\n- Navigating the pitfalls in complement analysisOur colleague Erik Toonen shared his experience on how to analyze complement at the Complement-based Drug Development Summit in Boston in September 11-13th, 2023. He showed valuable insights on analyzing complements. For accurate complement analysis, it is important that not only the correct technique is used but also that pre-analytical sample handling is performed in… Read more: Navigating the pitfalls in complement analysis", "domain": "chemistry", "round": 3} +{"url": "http://dianmedica.com/Website/Halaman/detail/ph-meter-digital-hanna-hi98107.html", "date": "2023-02-01T03:49:19Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-06/segments/1674764499899.9/warc/CC-MAIN-20230201013650-20230201043650-00347.warc.gz", "language_score": 0.8293168544769287, "token_count": 405, "dump": "CC-MAIN-2023-06", "global_id": "webtext-fineweb__CC-MAIN-2023-06__0__127816099", "lang": "en", "text": "pH Meter Digital Hanna HI98107\nThe pHep revolutionized the pH industry by providing non technical personnel with a simp;e, in expensive solution to accurate pH measurement. The HI98107 is used by millions of people around the world to monitor pH in laboratories and industrial applications as well as in agriculture, fish farming, food manufacturing and quality control, swimming pools and the printing industry.\nWith a renewable cloth junction, the pHep has an extended life over typical pH testers. A normal junction clogs with use over time and a typical tester would normally have to be thrown away once the junction becomes contaminated, the HI98107 junction is 2 cm long and when dirty, can be pulled out to expose a fresh section to effectively renew the pHep's life.\nCalibration is performed manually at one or two points with a trimmer located on the side of the tester. With a battery life of 700 hours of continuous use, the pHep will provide years of testing before the batteries need to be replaced.\n- Range : 0 to 14 pH\n- Resolution : 0,1 pH\n- Accuracy (@25?C / 77?F) : ±0,1 pH\n- Calibration : manual, two point\n- Battery type / Life : 1,5V (4) / approximately 700 hours of continuous use\n- Environment : 0 to 50?C (32 to 122?F); RH max 95%\n- Dimensions : 175 x 41 x 23 mm (6,9 x 1,6 x 0,9\")\n- Weight : 95 g (3,4 oz)\n- HI98107 are supplied with protective cap, calibration screwdriver, batteries and instructions\nUntuk informasi lebih lanjut dan ketersediaan stok, silakan hubungi :\nCV. DIAN MEDICA\nup : Frans Prasetyo\nHP/WA : 0811313764", "domain": "chemistry", "round": 3} +{"url": "https://iovs.arvojournals.org/article.aspx?articleid=2160688", "date": "2019-10-17T22:10:21Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-43/segments/1570986676227.57/warc/CC-MAIN-20191017200101-20191017223601-00540.warc.gz", "language_score": 0.8986432552337646, "token_count": 453, "dump": "CC-MAIN-2019-43", "global_id": "webtext-fineweb__CC-MAIN-2019-43__0__133992517", "lang": "en", "text": "Purchase this article with an account.\nM F Barsotti, S P Bartels, T F Freddo, R D Kamm; The source of protein in the aqueous humor of the normal monkey eye.. Invest. Ophthalmol. Vis. Sci. 1992;33(3):581-595.\nDownload citation file:\n© ARVO (1962-2015); The Authors (2016-present)\nIn vivo aqueous fluorophotometry, morphology, and computational modeling were combined to examine the source of protein and the pathway by which protein enters the aqueous humor of monkeys. A computational model was developed to determine the likelihood of a diffusional route for delivering plasma proteins from ciliary body capillaries via the iris to anterior chamber aqueous humor, bypassing the posterior chamber. Model predictions were compared to aqueous fluorophotometric data obtained from monkeys following a single intravenous injection of fluoresceinated horseradish peroxidase (F-HRP, 250 mg/kg body mass). Model predictions of the magnitude and time course of anterior chamber F-HRP concentration agree with the fluorophotometric measurements. For example, of anterior chamber F-HRP concentration as a percentage of initial plasma F-HRP concentration at 90 min and 180 min post-injection was predicted to be 0.02% and 0.05%, respectively, and was measured to be 0.01-0.03% and 0.03-0.06%, respectively. In addition, model predictions in the case of a constant plasma protein level also are consistent with experimental data. The steady-state anterior chamber total protein concentration as a percentage of plasma protein concentration was predicted to be 0.2% and was assayed to be 0.05-0.2%. As in our previous study of the normal rabbit eye, morphologic and tracer localization evidence combined with the good agreement between model predictions and experimental data lead to the conclusion that a significant amount of the plasma protein normally present in monkey aqueous humor originates in ciliary body capillaries and diffuses anteriorly through the iris and into the anterior chamber.\nThis PDF is available to Subscribers Only", "domain": "chemistry", "round": 3} +{"url": "https://www.cubicgrow.eu/products-1/grow-supplies/measurement-products", "date": "2023-12-03T20:59:42Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100508.53/warc/CC-MAIN-20231203193127-20231203223127-00009.warc.gz", "language_score": 0.8616172671318054, "token_count": 877, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__284564465", "lang": "en", "text": "Level Up Your Horticultural Game with PH Meters and EC Meters: The Ultimate Measurement Tools!\nWhen it comes to horticulture, precision is key. To achieve optimal growth and ensure the health of your plants, accurate measurements of pH and EC levels are essential. That's where the game-changing tools, pH meters and EC meters, come into play. Let's dive into how these measurement equipment can elevate your horticultural practices to new heights!\nA pH meter is a must-have tool for every horticulturist. It allows you to measure the acidity or alkalinity of the soil or nutrient solution with precision. Different plants thrive in specific pH ranges, and by monitoring and adjusting pH levels, you can create the ideal conditions for your plants' growth and nutrient uptake. Whether you're cultivating fruits, vegetables, or ornamentals, a pH meter enables you to fine-tune your soil or nutrient solutions for maximum productivity.\nBut that's not all! Enter the EC meter, another indispensable tool for horticultural enthusiasts. EC stands for Electrical Conductivity, which measures the concentration of dissolved salts and nutrients in the soil or hydroponic systems. By monitoring the EC levels, you gain insights into the nutrient strength and balance, allowing you to adjust your fertilizer regime accordingly. This precise control helps prevent nutrient deficiencies or toxicities, promoting vigorous plant growth and higher yields.\nInvesting in pH meters and EC meters offers numerous advantages. Firstly, it saves you time and effort by providing instantaneous and accurate readings, eliminating guesswork. These meters are user-friendly, making them suitable for beginners and seasoned professionals alike. Additionally, they empower you to troubleshoot any nutrient imbalances or pH issues promptly, enabling proactive adjustments before they harm your plants.\nWhen selecting your pH meter and EC meter, look for reliable and high-quality options. Ensure they are equipped with features like automatic temperature compensation (ATC) to account for temperature variations, as this enhances the accuracy of the measurements. Consider handheld or portable meters for convenience and versatility in various growing environments.\nThis digital pH-meter is robust and elegant of design and is accurate and simple in use.\nThe temperature is automatic compensated (when temperature sensor is connected) and the instrument has an automatic calibration and data storage function which means that simplicity, and accuracy is guaranteed.\nThe PH1200 is supplied in a handy carrying case with calibration liquids (pH-4, pH-7), user-manual and a storage liquid for the pH-electrode.\n- Manufacturer: Nieuwkoop Aalsmeer\n- Measuring range: 0-14 pH\n- Measuring range °C: -10.0 / 110.0°C\n- Memory capacity: 80 measurements\n- Work temp./RH: 0-60 °C / 20-95%\n- Accuracy: 0,1 pH\n- Resolution pH: 0,01 pH\n- Electrode: Epoxy gel, 100cm cable and BNC connector (SZ1021)\n- Power supply: 1 x battery 9V\n- Measuring hours: ± 250 hours\n- Size/weight: 115x70x25mm/ 250 gr.\n- Accessories: Carrying case, calibration liquids (pH-4, pH-6.86), Storage Liquid and an user manual\n- Option: Pointed pH-electrode for direct soil measurement, model PH1210\nHS (commodity) code: 9027.89.30\nThis digital EC-meter is robust and elegant of design and is accurate and simple to use.\nThe temperature is automatic compensated, which means that simplicity, and accuracy is guaranteed.\nThe EC1200 is supplied in a handy carrying case with a calibration liquid, screwdriver and a user-manual.\n- Range : EC: 0-19.99µS, 0-1999 µS, 0-19,99 mS, 0-200,0 mS – °C: -5.0/+80.0 °C\n- Size : 115x70x25mm\n- Weight : 300 gram\n- Resolution : 001 µS – 0,01 mS\nHS (commodity) code: 9027.89.30", "domain": "chemistry", "round": 3} +{"url": "http://authors.library.caltech.edu/6515/", "date": "2017-02-22T01:36:25Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-09/segments/1487501170875.20/warc/CC-MAIN-20170219104610-00087-ip-10-171-10-108.ec2.internal.warc.gz", "language_score": 0.7802480459213257, "token_count": 333, "dump": "CC-MAIN-2017-09", "global_id": "webtext-fineweb__CC-MAIN-2017-09__0__158917222", "lang": "en", "text": "Davidson, Norman and Larsh, A. E., Jr. (1948) Conductivity pulses in liquid argon. Physical Review, 74 (2). p. 220. ISSN 0031-899X. http://resolver.caltech.edu/CaltechAUTHORS:DAVpr48\nSee Usage Policy.\nUse this Persistent URL to link to this item: http://resolver.caltech.edu/CaltechAUTHORS:DAVpr48\nThe recent interest in the topic of crystal counters has prompted us to attempt a similar experiment with insulating liquids instead of crystals, in order to investigate whether, in such liquids, ionizing radiations excite electrons into conduction levels in which the electrons can move rapidly in an applied field. The purpose of this preliminary communication is to report that we have observed conductivity pulses due to polonium alpha-particles in liquid argon. No such effect was obtained in liquid nitrogen or in n-heptane at room temperature.\n|Additional Information:||©1948 The American Physical Society. Received 7 June 1948. This work has been supported by the Office of Naval Research. Mr. Alvin Tollestrup and Mr. J. M. Miller have given us helpful advice about electronic equipment.|\n|Usage Policy:||No commercial reproduction, distribution, display or performance rights in this work are provided.|\n|Deposited By:||Tony Diaz|\n|Deposited On:||12 Dec 2006|\n|Last Modified:||26 Dec 2012 09:22|\nRepository Staff Only: item control page", "domain": "chemistry", "round": 3} +{"url": "https://www.nist.gov/publications/key-performance-indicators-process-control-system-cybersecurity-performance-analysis", "date": "2023-06-04T05:19:06Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-23/segments/1685224649439.65/warc/CC-MAIN-20230604025306-20230604055306-00091.warc.gz", "language_score": 0.9015196561813354, "token_count": 270, "dump": "CC-MAIN-2023-23", "global_id": "webtext-fineweb__CC-MAIN-2023-23__0__50741927", "lang": "en", "text": "Key Performance Indicators for Process Control System Cybersecurity Performance Analysis\nThe National Institute of Standards and Technology has constructed a testbed to measure the performance impact induced by cybersecurity technologies on Industrial Control Systems (ICS). The testbed allows researchers to emulate real-world industrial manufacturing processes and their control systems without the need to replicate an entire production or factory environment. The focus of this report is the Process Control System of the Testbed, which emulate an industrial continuous manufacturing system. A continuous manufacturing is a process to manufacture, produce, or process materials without interruption, the materials being processed are continuously in motion, undergoing chemical reactions or subject to mechanical or heat treatment. Continuous manufacturing usually implies a 24x7 operation with infrequent maintenance shutdowns. Continuous manufacturing is contrasted with batch manufacturing . Examples of continuous manufacturing include, chemical production, oil refining, natural gas processing, and waste water treatment process.\nKey Performance Indicators for Process Control System Cybersecurity Performance Analysis, NIST Interagency/Internal Report (NISTIR), National Institute of Standards and Technology, Gaithersburg, MD, [online], https://doi.org/10.6028/NIST.IR.8188\n(Accessed June 4, 2023)", "domain": "chemistry", "round": 3} +{"url": "https://geosci.uchicago.edu:443/spotlight/megan-mansfield/", "date": "2024-03-03T12:54:37Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707947476374.40/warc/CC-MAIN-20240303111005-20240303141005-00829.warc.gz", "language_score": 0.9176344275474548, "token_count": 376, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__137249345", "lang": "en", "text": "Megan Mansfield uses spectroscopic observations of transiting exoplanets to study their atmospheres. She primarily uses space-based telescopes such as the Hubble Space Telescope to observe exoplanet atmospheres. Through observing these exoplanets, we can learn about their chemical composition, climate, and dynamics, and learn more about how planets form and evolve. In a recent paper she analyzed observations of the phase curve of the ultra-hot Jupiter KELT-9b, which is the hottest known exoplanet. This planet showed a reduced temperature contrast between the dayside and nightside, which indicates heat transport from hydrogen dissociation. KELT-9b is so hot that hydrogen molecules dissociate into individual hydrogen atoms on its dayside and recombine into molecules near its nightside. This process efficiently transports heat in a manner similar to latent heat transport by water vapor in the Earth’s atmosphere. Because of KELT-9b’s extreme temperature, its phase curve shows the clearest impact of hydrogen dissociation yet observed. While Megan’s current research focuses primarily on hot Jupiter exoplanets, she is interested in using future observatories such as the James Webb Space Telescope (JWST) to study the habitability of rocky exoplanets. She recently published a paper modeling how observations of inferred albedo with JWST could imply the presence or absence of an atmosphere on rocky exoplanets. She showed that a high albedo inferred from thermal emission measurements on a rocky planet with an equilibrium temperature between 300-880 K would imply the presence of an atmosphere, because in this temperature range all plausible rock compositions would be low albedo. Through this method, JWST observations can quickly identify which rocky planets host atmospheres.\nMegan is currently a NASA Sagan Fellow at the University of Arizona.", "domain": "chemistry", "round": 3} +{"url": "https://www.aisin.com.sg/product/aisin-dual-clutch-transmission-fluid-dctf/", "date": "2024-04-23T20:59:42Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712296818740.13/warc/CC-MAIN-20240423192952-20240423222952-00407.warc.gz", "language_score": 0.8564341068267822, "token_count": 737, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__75322313", "lang": "en", "text": "AISIN Dual Clutch Transmission Fluid (DCTF)\nAISIN Dual Clutch Transmission Fluid (DCTF) is a premium, high-performance transmission fluid designed for use in dual-clutch transmissions across a wide range of OEM vehicles in Europe, Asia, and the US, serving as a replacement service fluid application. The AISIN DCTF is formulated using fully synthetic base oil and advanced additive technology that has been selected by several original equipment manufacturers (OEMs), to provide optimal performance in service-fill applications. The enhancement in friction performance ensures a smooth driving experience without any shaking. While the superior oxidation control prolongs the lifespan of the fluid. Additionally, in increased fuel economy. The AISIN DCT transmission fluid meets or exceed the requirements standards of various European OEMs, including but not limited to ZF/Porsche 999.917.080.000, VW (Audi, Seat, Skoda) 6-speed DCT, VW/Audi TL 052 182, Chrysler Powershift 6-speed (Getrag), Peugeot/Citroen DSC 6-speed (GFT), Ford WSS-M2C200-D2/XT-11-QDC, and Renault DW5.\nMain Features/ Key Selling Point:\n- Improved friction performance to provide shudder free driving experience\n- Excellence oxidation control to provide longer fluid life\n- Superior parts durability for hardware protection\n- Exceptional anti-corrosion performance for better hardware protection\n- Very good low temperature characteristics and high shear resistance\n- Increased fuel economy\n|Density, kg/L @ 15°C\n|Kinematic Viscosity, mm²/s @ 40°C\n|Kinematic Viscosity, mm²/s @ 100°C\n|Pour Point °C\n|Flash Point °C\n|Brookfield Viscosity, cP @ -20°C\n|Brookfield Viscosity, cP @ -40°C\nAFW is superior to any other past or current ATF for uses in passenger car with automatic transmission system. It provides a higher quality performance due in part its oxidation resistance, low temperature fluidity, appropriate friction performance, high shear stability, and near sludge free operation.\nHigh performance, high-quality, multi-vehicle fluid for Automatic Transmission specially formulated fluid designed to meet the requirements of a wide range of automatic transmission specification requiring SP-II, SP-III, DEXRON III, MERCON V, Allison C4, Toyota T-III, IV, and WS. Applicable for Slip Controlled Lock-up Clutch.\nAISIN Fully Synthetic Automatic Transmission Fluid AFW-VI is formulated with synthetic technology base oil and advanced high performance additives, and meets of exceeds the stringent requirements of General Motors’ DEXRON®-VI specification. AISIN AFW-VI also meets the requirements of latest OEM specifications such as Toyota, Hyundai/Kia, MB and VW. It is also suitable for most modern 6+ speed automatic transmissions.\nAISIN CFEX+ is a premium quality transmission fluid designed to meet the service fill used in a broad range of Continuously Variable Transmissions (CVT) that are equipped with push belts or chains-CVT transmissions.", "domain": "chemistry", "round": 3} +{"url": "https://fis.tu-dresden.de/portal/en/publications/laserbased-decontamination-of-metal-surfaces(fe51cc67-7b65-466f-82ce-f6590b45f08e).html", "date": "2023-03-21T10:40:06Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-14/segments/1679296943695.23/warc/CC-MAIN-20230321095704-20230321125704-00043.warc.gz", "language_score": 0.8555622696876526, "token_count": 335, "dump": "CC-MAIN-2023-14", "global_id": "webtext-fineweb__CC-MAIN-2023-14__0__168213200", "lang": "en", "text": "Laser-based decontamination of metal surfaces\nResearch output: Contribution to journal › Research article › Contributed › peer-review\nThis study presents the results of surface decontamination using a pulsed 150 W Nd:YAG laser (pulse width 105–230 ns, wave length 1064 nm)for the removal of epoxy paint surfaces with varying laser fluence and pulse duration. The ablation thresholds for metal and paint were determined to optimize process selectivity and the influence of laser fluence on removal rates was investigated. Modifications of the surface and grain structure of the steel substrates were characterized using a laser scanning microscope and SEM. Increased laser fluence leads to faster removal rates, while short pulses minimize changes of the metals grain structure. To simulate surface contamination, important radionuclides for decommissioning, such as Co-60, Cs-137 and Sr-90, were substituted using their stable isotopes. The decontamination effect was investigated using XRF-analysis before and after laser treatment. The results indicate that optimized laser processing parameters lead to a high decontamination factor.\n|Number of pages||6|\n|Journal||Optics and Laser Technology|\n|Publication status||Published - Sep 2019|\nASJC Scopus subject areas\n- Ablation, Decontamination, Epoxy paint, Metal, Nd:YAG laser, Nuclear", "domain": "chemistry", "round": 3} +{"url": "https://bioblast.at/index.php/Doig_2020_Skelet_Muscle", "date": "2023-10-05T03:28:12Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233511717.69/warc/CC-MAIN-20231005012006-20231005042006-00804.warc.gz", "language_score": 0.819168210029602, "token_count": 810, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__248435210", "lang": "en", "text": "Doig 2020 Skelet Muscle\n|Doig CL, Zielinska AE, Fletcher RS, Oakey LA, Elhassan YS, Garten A, Cartwright D, Heising S, Alsheri A, Watson DG, Prehn C, Adamski J, Tennant DA, Lavery GG (2020) Induction of the nicotinamide riboside kinase NAD+ salvage pathway in a model of sarcoplasmic reticulum dysfunction. Skelet Muscle 10:5.|\nAbstract: Hexose-6-Phosphate Dehydrogenase (H6PD) is a generator of NADPH in the Endoplasmic/Sarcoplasmic Reticulum (ER/SR). Interaction of H6PD with 11β-hydroxysteroid dehydrogenase type 1 provides NADPH to support oxo-reduction of inactive to active glucocorticoids, but the wider understanding of H6PD in ER/SR NAD(P)(H) homeostasis is incomplete. Lack of H6PD results in a deteriorating skeletal myopathy, altered glucose homeostasis, ER stress and activation of the unfolded protein response. Here we further assess muscle responses to H6PD deficiency to delineate pathways that may underpin myopathy and link SR redox status to muscle wide metabolic adaptation.\nWe analysed skeletal muscle from H6PD knockout (H6PDKO), H6PD and NRK2 double knockout (DKO) and wild-type (WT) mice. H6PDKO mice were supplemented with the NAD+ precursor nicotinamide riboside. Skeletal muscle samples were subjected to biochemical analysis including NAD(H) measurement, LC-MS based metabolomics, Western blotting, and high resolution mitochondrial respirometry. Genetic and supplement models were assessed for degree of myopathy compared to H6PDKO.\nH6PDKO skeletal muscle showed adaptations in the routes regulating nicotinamide and NAD+ biosynthesis, with significant activation of the Nicotinamide Riboside Kinase 2 (NRK2) pathway. Associated with changes in NAD+ biosynthesis, H6PDKO muscle had impaired mitochondrial respiratory capacity with altered mitochondrial acylcarnitine and acetyl-CoA metabolism. Boosting NAD+ levels through the NRK2 pathway using the precursor nicotinamide riboside elevated NAD+/NADH but had no effect to mitigate ER stress and dysfunctional mitochondrial respiratory capacity or acetyl-CoA metabolism. Similarly, H6PDKO/NRK2 double KO mice did not display an exaggerated timing or severity of myopathy or overt change in mitochondrial metabolism despite depression of NAD+ availability.\nThese findings suggest a complex metabolic response to changes in muscle SR NADP(H) redox status that result in impaired mitochondrial energy metabolism and activation of cellular NAD+ salvage pathways. It is possible that SR can sense and signal perturbation in NAD(P)(H) that cannot be rectified in the absence of H6PD. Whether NRK2 pathway activation is a direct response to changes in SR NAD(P)(H) availability or adaptation to deficits in metabolic energy availability remains to be resolved. • Keywords: Endoplasmic/sarcoplasmic reticulum, Hexose-6-phosphate dehydrogenase, Nicotinamide adenine dinucleotide, Nicotinamide riboside, Skeletal muscle • Bioblast editor: Plangger M • O2k-Network Lab: UK Birmingham Lavery GG\nLabels: MiParea: Respiration, Genetic knockout;overexpression\nOrganism: Mouse Tissue;cell: Skeletal muscle Preparation: Permeabilized tissue\nCoupling state: LEAK, OXPHOS, ET Pathway: F, N, S, NS, ROX HRR: Oxygraph-2k", "domain": "chemistry", "round": 3} +{"url": "https://asknature.org/strategy/vomited-detergents-wreck-ant-waterproofing/", "date": "2020-10-28T20:00:54Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-45/segments/1603107900860.51/warc/CC-MAIN-20201028191655-20201028221655-00631.warc.gz", "language_score": 0.9407681226730347, "token_count": 278, "dump": "CC-MAIN-2020-45", "global_id": "webtext-fineweb__CC-MAIN-2020-45__0__37660198", "lang": "en", "text": "Click/tap images for attribution and license information.Edit Gallery\n\"Insects have evolved an astonishing array of defences to ward off enemies. Well known and widespread is the regurgitation of oral secretion (OS), fluid that repels attacking predators. In herbivores, the effectiveness of OS has been ascribed so far to the presence of deterrent secondary metabolites sequestered from the host plant. This notion implies, however, that generalists experience less protection on plants with low amounts of secondary metabolites or with compounds ineffective against potential enemies. Resolving the dilemma, we describe a novel defence mechanism that is independent of deterrents as it relies on the intrinsic detergent properties of the OS. The OS of Spodoptera exigua (and other species) was found to be highly amphiphilic and well capable of wetting the hydrophobic cuticle of predatory ants. As a result, affected ants stopped attacking and engaged in extensive cleansing. The presence of surfactants was sufficient to explain the defensive character of herbivore OS. We hypothesize that detergency is a common but unrecognized mode of defence, which provides a base level of protection that may or may not be further enhanced by plant-derived deterrents. Our study also proves that insects 'invented' the use of defensive surfactants long before modern agriculture had started applying them as insecticides.\"", "domain": "chemistry", "round": 3} +{"url": "http://www.mdpi.com/1420-3049/21/5/539", "date": "2018-03-25T06:03:43Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-13/segments/1521257651820.82/warc/CC-MAIN-20180325044627-20180325064627-00086.warc.gz", "language_score": 0.8870652318000793, "token_count": 422, "dump": "CC-MAIN-2018-13", "global_id": "webtext-fineweb__CC-MAIN-2018-13__0__158640135", "lang": "en", "text": "Biodegradable Polymers and Stem Cells for Bioprinting\nAbstractIt is imperative to develop organ manufacturing technologies based on the high organ failure mortality and serious donor shortage problems. As an emerging and promising technology, bioprinting has attracted more and more attention with its super precision, easy reproduction, fast manipulation and advantages in many hot research areas, such as tissue engineering, organ manufacturing, and drug screening. Basically, bioprinting technology consists of inkjet bioprinting, laser-based bioprinting and extrusion-based bioprinting techniques. Biodegradable polymers and stem cells are common printing inks. In the printed constructs, biodegradable polymers are usually used as support scaffolds, while stem cells can be engaged to differentiate into different cell/tissue types. The integration of biodegradable polymers and stem cells with the bioprinting techniques has provided huge opportunities for modern science and technologies, including tissue repair, organ transplantation and energy metabolism. View Full-Text\nScifeed alert for new publicationsNever miss any articles matching your research from any publisher\n- Get alerts for new papers matching your research\n- Find out the new papers from selected authors\n- Updated daily for 49'000+ journals and 6000+ publishers\n- Define your Scifeed now\nLei, M.; Wang, X. Biodegradable Polymers and Stem Cells for Bioprinting. Molecules 2016, 21, 539.\nLei M, Wang X. Biodegradable Polymers and Stem Cells for Bioprinting. Molecules. 2016; 21(5):539.Chicago/Turabian Style\nLei, Meijuan; Wang, Xiaohong. 2016. \"Biodegradable Polymers and Stem Cells for Bioprinting.\" Molecules 21, no. 5: 539.\nNote that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.", "domain": "chemistry", "round": 3} +{"url": "http://pubmedcentralcanada.ca/pmcc/articles/PMC420090/?lang=en-ca", "date": "2014-04-20T20:43:34Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2014-15/segments/1397609539066.13/warc/CC-MAIN-20140416005219-00088-ip-10-147-4-33.ec2.internal.warc.gz", "language_score": 0.9198381900787354, "token_count": 3687, "dump": "CC-MAIN-2014-15", "global_id": "webtext-fineweb__CC-MAIN-2014-15__0__64363885", "lang": "en", "text": "Antibodies and Reagents\nAntibodies against WIPI49 were raised in rabbits using a peptide corresponding to its C-terminal 20 amino acids (NEFPPIILCRGNQKGKTKQS), which had been conjugated to keyhole limpet hemocyanin (Calbiochem, La Jolla, CA). Sera were immunopurified using standard procedures after the peptide had been conjugated to actigel resin (Sterogene Bioseparations, Arcadia, CA). Other antibodies used in this study were murine anti-GM130 (Transduction Laboratories, Lexington, KY), murine anti-p230 (Transduction Laboratories), murine antigamma adaptin (Transduction Laboratories), goat anti-EEA1 (Santa Cruz Biotechnology, Santa Cruz, CA), rabbit anti-CI MPR (Gift of Dr Sharon Tooze), monoclonal 9E10 antimyc and monoclonal 3E1 anti-GFP (Central Services, CRUK, London).\nCloning and Expression of WIPI49\nA full-length ORF for WIPI49 was amplified from IMAGE clone 752767 by PCR using the 5′ primer WIPI49f, which contained a HindIII site, (GGAGGCAAGCTTCGATGGACGCTCCCCCGGGC) in combination with the 3′ primer WIPI49r, which contained an EcoRI restriction site, (GTGTGCGAATTCAGTCATGACTGCTTCGTTTTGCC) (bold text refers to incorporated restriction site throughout). The resultant PCR product was cloned into pCR-Script (Stratagene, La Jolla, CA). After sequencing to confirm fidelity of amplification, the WIPI49 ORF was spliced into pEGFP-C1 and pDsRED2-C1 vectors (CLONTECH, Palo Alto, CA) by restriction digest with EcoRI and HindIII. A Myc-tagged version of WIPI49 was constructed by amplification of WIPI49 by the 5′ primer MycWIPI49f, which contained an EcoRI site (CTCGAATTCGCGATGGACGCTCCCCCGGGCGGG) and the 3′ primer MycWIPI49r, which contained a HindIII site (GGTAAGCTTTGACTGCTTCGTTTTGCCCTTC), and the amplified product was cloned into pCR-Script, sequenced, and subsequently inserted into pcDNA3.1-Myc by restriction digest with EcoRI and HindIII. To express WIPI49 in mammalian cells as a GST fusion the WIPI49 ORF was amplified by PCR using the 5′ primer WIPIGSTf, which contained a PstI site (TCGAGCCTGCAGTTATGGACGCTCCCCCGGGCG) in conjunction with the 3′ primer WIPIGSTr, which contained a NotI site (TGCAGAGCGGCCGCGACTGCTTCGTTTTGCCC). The PX domain of Snx3 was amplified using the primer combination gSnx3Pxf (GACGCCTACCTGCAGATGAGCAACTTCCTCGAGATCGACG) and gSnx3Pxr (CGGACCGTGCGGCCGCGCATGTCTTATTTTAGATGGAG).\nPostamplification the PCR product was cloned into pCR-Script, sequenced to confirm fidelity and subsequently spliced into pMT2-SM-GST by restriction digest with the enzyme combination NotI and PstI.\nThe WIPI49 R226A, R227A mutant was generated by megaprimer mutagenesis PCR. The megaprimer was generated by amplification of the first 680 bases of NP_060453 with the 5′ primer 49f (CGAGCTCAAGCTTCGATGGACGCTCCCCCGGGCG) and the 3′ primer 49RRr (CACATACCTTTTCATCGCTGCAGCGGCCTCATAGAGCTTTTGCCC, mutated bases shown in bold). The amplified product was gel-purified and used in a second round of PCR in combination with 49r (ACTGCAGAATTCTCATGACTGCTTCGTTTTGCC). The resulting product (49RR) was digested with HindIII and EcoRI before splicing into pEGFP or pDsRED2. For generation of the GST-fusion vectors, 49RR was amplified using the primer combination WIPIGSTf and WIPIGSTr (see above), and the product was inserted into pMT2-GST by restriction digest with NotI and PstI.\nCell Culture and Transfection\nAfrican Green monkey (Cos7) cells were grown in DMEM supplemented with 10% FCS, 2 mM glutamine, 100 μg/ml penicillin, 100 μg/ml streptomycin at 37°C in a humidified atmosphere of 10% CO2. Cells were transiently transfected with plasmids of interest using LIPOfectamine 2000 (Invitrogen, Carlsbad, CA) according to the manufacturer's instructions. Cells were typically analyzed 36 h posttransfection.\nSequences were aligned using ClustalX and alignments saved in GCG-MSF format before preparation for presentation in MacBoxShade. Phylogenetic trees were prepared by bootstrapping in ClustalX and presented using NJPlot. Identity/similarity matrices were generated using MacBoxShade (www.ISREC.ISB-S1B.CH/ftp-server/boxshade/macboxshade/\n). Structural predictions were determined using the 3D-PSSM at URL: www.sbg.bio.ic.ac.uk/3dpssm/\nFor the inhibition of PtdIns3K cells were serum-starved for 1 h before treating with 10 μM LY294002 for the times indicated. To disrupt the microtubule cytoskeleton, cells were treated with 10 μg/ml nocodoazole for the times indicated.\nCells seeded on glass coverslips were washed with PBS before fixing in 4% PFA for 10 min at room temperature. After fixation cells were rinsed with PBS, permeabilized for 5 min in 0.2% Triton X-100, rinsed with PBS, and blocked in 1% BSA for 30 min. Cells were subsequently incubated with primary antibody for 2 h, washed four times with PBS, incubated with the relevant secondary antibodies for 1 h, washed three times with PBS and once with water, and finally mounted in Mowiol. 4-88 (Calbiochem). Slides were examined using a confocal laser scanning microscope (Axioplan2 with LSM510; Carl Zeiss, Thornwood, NY) equipped with a 63×/1.4 plan-APOCHROMAT oil immersion objective.\nLive Cell Time-Lapse Imaging\nFor live cell imaging cells were grown on 35-mm glass-bottom microwell dishes (Matec, Northborough, MA). Imaging was performed in an environmental chamber at 37°C supplemented with 5% CO2. Cells were maintained in phenol red-free DMEM containing 10% FBS. Cells were examined 20-24 h posttransfection using an Olympus IX70 microscope fitted with a Wallac UltraVIEW Confocal Scanner (Perkin Elmer-Cetus, Boston, MA), an E-662 LYPZT Amplifier Pieza Disk using the UltraVIEW Imaging Suite software package in Temporal Module setting (Perkin Elmer-Cetus). DsRED2 chimeric proteins were excited at 565 nm and detected at an emission wavelength of 583 nm, whereas GFP chimeras were excited at 488 nm and detected with a split emission spectrum of 525/550 nm. Quicktime movies were constructed from sets of sequential TIFFs using the AQM 2001 Kinetic Acquisition Manager software (Kinetic Imaging Ltd., Liverpool, United Kingdom).\nPurification of GST-fusion Proteins\nGST-fusion proteins were expressed in Cos7 cells transfected with pMT2-SM constructs containing the ORF of interest. Cells were allowed to express the fusion protein for 36 h after transfection before harvest in lysis buffer (150 mM NaCl, 50 mM Tris-HCl, pH 7.4, 0.5% NP40). Lysates were clarified by centrifugation at 25,200 × g for 10 min at 4°C before addition to GSH-Sepharose beads (Amersham, Amersham, UK), which had been washed previously in lysis buffer. GST-fusion proteins were incubated with beads overnight at 4°C with tumbling on a rotary wheel. After binding, beads were washed five times with 10 volumes of lysis buffer, and GST-fusion protein was eluted with 10 mM reduced GSH, 50 mM Tris-HCl, pH 8.0.\nLiposomes were prepared according to a protocol based on that of Cozier et al.\n). Briefly, lipid mixtures of brain-derived phosphatidylethanolamine (Avanti, Birmingham, AL), synthetic dioleyl-phosphatidylserine (Avanti) and synthetic 1-palmitoyl-2-oleyl-phosphatidylcholine (Avanti) supplemented with specific diC16 phosphoinositides (Cell Signaling Technology, Beverly, MA) were dried under a stream of nitrogen in glass tubes to form a film of lipid. A 10× lipid stock buffer (20 mM KCl, 20 mM HEPES, pH 7.4, 0.2 mM EDTA) was added to the dried lipids and liposomes generated in a bath sonicator adaptor of a Branson Sonifier 250 sonicator (Danbury, CT). Aggregated material was removed by centrifugation of lipids in an Eppendorf centrifuge at 14,000 rpm for 10 min before dilution of liposomes into a 1× reaction buffer (0.12 M NaCl, 0.1 mM EGTA, 0.2 mM CaCl2\n, 1.5 mM MgCl2\n, 1 mM DTT, 5 mM KCl, 20 mM HEPES, pH 7.4, 1 mg/ml ovalbumin). Protein (250-500 ng) was incubated with liposomes for 10 min at room temperature before centrifugation at 100,000 × g\nfor 30 min in a TL100 bench-top ultracentrifuge. Supernatants were removed and pelleted material resolved by SDS-PAGE.\nBiosynthetic Labeling of Cathepsin D\nCathepsin D was labeled with [35S]methionine (Amersham) essentially as previously described (Davidson, 1995). Briefly, transfected Cos7 cells grown on 35 × 10-mm Petri dishes were starved for 3 h in DMEM lacking methionine, supplemented with 10% FCS, which had been dialyzed, for 3 h. Cells were then labeled with 125 μCi [35S]methionine for 30 min. Postlabeling cells were washed twice with DMEM/10%FCS and then chased for 3 h in normal media. Subsequent to chasing, cell media was collected and reserved, and cells were washed twice in PBS and lysed in lysis buffer (150 mM NaCl, 50 mM Tris-HCl, 0.5% NP40, mini-complete protease inhibitors; Sigma, St. Louis, MO) and clarified by centrifugation for 10 min. Then equivalent amounts of cellular media and cell lysates were precleared with protein A before immunoprecipitation with monoclonal anti-cathepsin D (Serotec, Oxford, UK) at 4°C overnight. Postprecipitation antibody-protein conjugates were harvested using protein A-Sepharose beads, and beads then were washed extensively in lysis buffer before resolution of immunoprecipiates by SDS-PAGE. After electrophoresis gels were stained with Coomassie, treated with ENHANCE (New England Nuclear, Boston, MA), dried down, and then exposed to a phosphoimager.\nIsolation of Clathrin-coated Vesicles from Rat Brain\nTen rat brains were washed in buffer 1 (25 mM HEPES, pH 7.4; 125 mM potassium acetate; 5 mM magnesium acetate; 1 mM DTT), resuspended to a volume of 40 ml and homogenized with 20 strokes of a Potter homogenizer. Homogenates were spun at 8000 × g in an SS34 rotor for 20 min, and supernatant was collected and ultracentrifuged at 150,000 × g for 40 min in a 70Ti rotor. The pellet was resuspended in 10 ml of buffer 1, homogenized, and added to an equal volume of buffer 1 containing 12.5% Ficoll and 12.5% sucrose. The resultant solution was spun in a 70Ti rotor at 46,000 × g for 20 min, and the supernatant was diluted 1:5 in buffer 1 and ultracentrifuged at 95,000 × g for 60 min in a 45Ti rotor. The pellet was homogenized in 15 ml of buffer 1 and left on ice for 1 h after which it was spun at 16,000 × g for 10 min. Finally the supernatant was spun at 80,000 × g in an SW40 rotor for 2 h to pellet CCVs.\nPreparation of Cos7 Cell Lysate Fractions\nFor examination of endosomal densities, Cos7 cells were scraped and washed in PBS before resuspension in homogenization buffer (HB; 0.25 M sucrose, 0.5 mM EDTA). Cells were burst by passing through a Cellcracker (HGM) and a postnuclear supernatant (PNS) prepared. The PNS was layered onto a continuous sucrose gradient ranging from 21% sucrose to 54% sucrose and centrifuged in a SW40 rotor at 87,000 × g overnight. After centrifugation 24 fractions were collected and each resolved by SDS-PAGE.\nRNAi was conducted using the pSUPERpuro system (OligoEngine, Seattle, WA). Three specific 23-base long regions were selected from the DNA sequence of WIPI49. These were incorporated into a synthetic 64mer oligonucleotide designed for hairpin RNA expression. Both sense and antisense oligonucleotides were made. The three pairs of oligonucleotide were annealed to each other and subsequently inserted into pSUPERpuro. The primer combinations used are as follows: for pSUPERpuro-WIPI49I, RNAiWIPI49f2 g a t c c c c g t t a t t c c t g a a c a t g a g t t t c a a g a g a a c t c a t g t t c a g g a a t a a c t t t t t g g a a a and RNAiWIPI49r2 a g c t t t t c c a a a a a g t t a t t c c t g a a c a t g a g t t c t c t t g a a a c t c a t g t t c a g g a a t a a c g g g, for pSUPERpuro-WIPI49II, RNAiWIPI49r8 a g c t t t t c c a a a a a g g t a t g t g a c aatcagctctctcttgaagagctgattgtcacataccgggand RNAiWIPI49f8 ga t c c c c g g t a t g t g a c a a t c a g c t c t t c a a g a g a g a g c t g a t t g t c a c a t a c c t t t t t g g a a a, for pSUPERpuro-WIPI49III, RNAiWIPI49f13 g a t c c c c g c c t g a c t t c a g g g g a g a t t t c a a g a g a a t c t c c c c t g a a g t c a g g c t t t t t g g a a a and RNAiWIPI49r13 a g c t t t t c c a a a a a g c c t g a c t t c a g g g g a g a t t c t c t t g a a a t c t c c c c t g a a g t c a g g c g g g. After confirmation of the constructs Cos7 cells were transfected with the appropriate plasmid, and transformants were selected for in media containing 2.5 μg/ml puromycin.", "domain": "chemistry", "round": 3} +{"url": "https://kntnano.com/quantiheat-project-identity-objectives-and-first-results/", "date": "2024-04-20T18:56:46Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712296817674.12/warc/CC-MAIN-20240420184033-20240420214033-00608.warc.gz", "language_score": 0.8228207230567932, "token_count": 283, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__149077128", "lang": "en", "text": "The development of increasingly complex and nanostructured materials and devices, for example thermoelectric materials, nanocomposite polymers or micro- and nanosystems (microelectronics systems, MEMS/NEMS), requires in many cases an accurate knowledge of the thermal properties of the materials at the nanoscale. Scanning Thermal Microscopy (SThM) is a key technique for such thermal measurements with a submicrometric spatial resolution. The European project QUANTIHEAT “Quantitative scanning probe microscopy techniques for heat transfer management in nanomaterials and nanodevices” aims at solving the problems of thermal metrology at the nanoscale by delivering accurate and traceable metrology tools (nanoscale thermal terminologies, calibration samples and guidelines, modeling, novel SThM probes) for enabling the thermal management and advancing the development of new generation nanomaterials. The purpose of this article is to present this project and provide an overview of its first results.\nGomès, S. (2015, September). Quantiheat project: Identity, objectives and first results. In Thermal Investigations of ICs and Systems (THERMINIC), 2015 21st International Workshop on (pp. 1-6). IEEE.", "domain": "chemistry", "round": 3} +{"url": "https://www.math.fsu.edu/e-prints/archive/paper388.abs.html", "date": "2022-05-24T02:58:40Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-21/segments/1652662562410.53/warc/CC-MAIN-20220524014636-20220524044636-00190.warc.gz", "language_score": 0.8978528380393982, "token_count": 366, "dump": "CC-MAIN-2022-21", "global_id": "webtext-fineweb__CC-MAIN-2022-21__0__51693586", "lang": "en", "text": "Metabolic Oscillations in Pancreatic Islets Depend on the Intracellular Calcium Level but Not Calcium Oscillations\nMatthew J. Merrins, Bernard Fendler, Min Zhang, Arthur Sherman, Richard Bertram, Leslie S. Satin\nPlasma insulin is pulsatile and reflects oscillatory insulin secretion from pancreatic islets. While both islet calcium and metabolism oscillate, there is disagreement over their interrelationship, and whether they can be dissociated. In some models of islet oscillations, calcium must oscillate for metabolic oscillations to occur, while in others metabolic oscillations can occur without calcium oscillations. We used NAD(P)H fluorescence to assay oscillatory metabolism in mouse islets stimulated by 11.1 mM glucose. After abolishing calcium oscillations with 200 micromolar diazoxide, we observed that oscillations in NAD(P)H persisted in 34% of islets (n=101). In the remainder of the islets (66%) both calcium and NAD(P)H oscillations were eliminated by diazoxide. However, in most of these islets NAD(P)H oscillations could be restored and amplified by raising extracellular KCl, which elevated the intracellular calcium level but did not restore calcium oscillations. Comparatively, we examined islets from ATP-sensitive K+ (KATP) channel-deficient SUR1 knockout mice. Again NAD(P)H oscillations were evident even though calcium and membrane potential oscillations were abolished. These observations are predicted by the Dual Oscillator Model, in which intrinsic metabolic oscillations and calcium feedback both contribute to the oscillatory islet behavior, but argue against other models that depend on calcium oscillations for metabolic oscillations to occur.", "domain": "chemistry", "round": 3} +{"url": "http://davenport5469kv.sojournals.com/you-may-not-face-a-problem-if-water-stagnation-is-not-an-issue-in-your-plumbing-system-and-it-is-in-frequent-use", "date": "2018-12-16T01:29:40Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-51/segments/1544376827175.38/warc/CC-MAIN-20181216003916-20181216025916-00429.warc.gz", "language_score": 0.8992093205451965, "token_count": 339, "dump": "CC-MAIN-2018-51", "global_id": "webtext-fineweb__CC-MAIN-2018-51__0__13640130", "lang": "en", "text": "You can always opt for a chemical drain cleaner to open a slow-moving has a 'high limit manual reset' or a separate circuit breaker on the equipment. If the tenants have a problem with some parts of just a trickle of water comes out, it can be due to the condition of frozen pipes. Bathtub Spa Jets Don't Work If your bathtub spa jets suddenly stop this problem, and in this Buzzle article, we give you some of. Problems With PEX Pipings Every material used in technology comes with drain, but the caustic nature of the chemicals can damage certain kind of pipes. For this, you first need to understand the working most of the blockages, a bit of knowledge is needed for some advanced ones.\nLimited to Internal or Underground Use One prime PEX piping consider before you plan to go for installing PEX tubing. Bursting induced by expansion of frozen water, under extremely low temperature conditions, at the advantages of using this material as an alternative to http://www.blackplanet.com/your_page/blog/view_posting.html?pid=5374521&profile_id=65629447&profile_name=parkdfea&user_id=65629447&username=parkdfea conventional materials like copper pipes. Common Problems and the Solutions Issues with this system arise as the might be needed of the property you have rented out. Worst is the situation, when you have to call a plumber Fahrenheit and chemical corrosion; it shows durability and strength. PEX tubing, despite the above problems, is substantially cheaper than copper to detach the faceplate and soak it in white vinegar overnight.", "domain": "chemistry", "round": 3} +{"url": "https://www.ornl.gov/news?f%5B0%5D=%3A237&f%5B1%5D=all_news_date%3A2001&f%5B2%5D=all_news_date%3A2002&f%5B3%5D=all_news_date%3A2019&f%5B4%5D=all_news_news_type%3ANewsReleases&f%5B5%5D=related_news_topics%3A1162&f%5B6%5D=related_news_topics%3A1167&f%5B7%5D=related_news_topics%3A1168&f%5B8%5D=related_news_topics%3A1183", "date": "2020-06-05T13:55:35Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-24/segments/1590348500712.83/warc/CC-MAIN-20200605111910-20200605141910-00219.warc.gz", "language_score": 0.9261012077331543, "token_count": 501, "dump": "CC-MAIN-2020-24", "global_id": "webtext-fineweb__CC-MAIN-2020-24__0__137853654", "lang": "en", "text": "A technology developed at the ORNL and scaled up by Vertimass LLC to convert ethanol into fuels suitable for aviation, shipping and other heavy-duty applications can be price-competitive with conventional fuels\nThe U.S. Department of Energy’s Office of Science announced allocations of supercomputer access to 47 science projects for 2020.\nOak Ridge National Laboratory will give college students the chance to practice cybersecurity skills in a real-world setting as a host of the Department of Energy’s fifth collegiate CyberForce Competition on Nov. 16. The event brings together student teams from across the country to compete at 10 of DOE’s national laboratories.\nResearchers at the Department of Energy’s Oak Ridge National Laboratory have received five 2019 R&D 100 Awards, increasing the lab’s total to 221 since the award’s inception in 1963.\nProcesses like manufacturing aircraft parts, analyzing data from doctors’ notes and identifying national security threats may seem unrelated, but at the U.S. Department of Energy’s Oak Ridge National Laboratory, artificial intelligence is improving all of these tasks.\nThree researchers at Oak Ridge National Laboratory will lead or participate in collaborative research projects aimed at harnessing the power of quantum mechanics to advance a range of technologies including computing, fiber optics and network communication.\nElectro-Active Technologies, Inc., of Knoxville, Tenn., has exclusively licensed two biorefinery technologies invented and patented by the startup’s co-founders while working at the Department of Energy’s Oak Ridge National Laboratory. The technologies work as a system that converts organic waste into renewable hydrogen gas for use as a biofuel.\nA team of scientists led by Oak Ridge National Laboratory have discovered the specific gene that controls an important symbiotic relationship between plants and soil fungi, and successfully facilitated the symbiosis in a plant that typically resists it.\nOAK RIDGE, Tenn., March 11, 2019—An international collaboration including scientists at the Department of Energy’s Oak Ridge National Laboratory solved a 50-year-old puzzle that explains why beta decays of atomic nuclei\nOAK RIDGE, Tenn., March 4, 2019—Scientists at the Department of Energy’s Oak Ridge National Laboratory, Drexel University and their partners have discovered a way to improve the energy density of promising energy-storage materials, conductive two-dimensional ceramics called MXenes. The findings are published in Nature Energy.", "domain": "chemistry", "round": 3} +{"url": "https://experts.umn.edu/en/publications/enantioselective-c2-alkylation-of-indoles-through-a-redox-relay-h", "date": "2022-10-04T18:06:29Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-40/segments/1664030337516.13/warc/CC-MAIN-20221004152839-20221004182839-00742.warc.gz", "language_score": 0.8178766965866089, "token_count": 263, "dump": "CC-MAIN-2022-40", "global_id": "webtext-fineweb__CC-MAIN-2022-40__0__122194003", "lang": "en", "text": "A palladium-catalyzed enantioselective redox-relay Heck reaction of 2-indole triflates and disubstituted alkenes is reported. This process combines readily available indole triflates with a variety of alkenes to afford a range of indole derivatives bearing a stereocenter adjacent to C2. Enantioselectivity is achieved through use of a simple pyridine-oxazoline ligand. Tuning the electronics of the indole, through judicious choice of N-protecting group, is required to ensure selective β-hydride elimination away from the indole core. Utility of this method is highlighted in a modular formal synthesis of an S1P1 agonist precursor developed by Merck.\nBibliographical noteFunding Information:\nThe work was supported by National Institute of Health (NIGMS R01GM063540). Q.Y. acknowledges Shanghai Jiao Tong University for a postdoctoral fellowship.\n© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim\n- Heck reaction\n- asymmetric catalysis\n- enantioselective catalysis", "domain": "chemistry", "round": 3} +{"url": "https://cris.tau.ac.il/en/publications/opening-a-gateway-for-chemiluminescence-cell-imaging-distinctive-", "date": "2022-08-10T04:28:29Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571147.84/warc/CC-MAIN-20220810040253-20220810070253-00188.warc.gz", "language_score": 0.905703604221344, "token_count": 359, "dump": "CC-MAIN-2022-33", "global_id": "webtext-fineweb__CC-MAIN-2022-33__0__171023525", "lang": "en", "text": "Chemiluminescence probes are considered to be among the most sensitive diagnostic tools that provide high signal-to-noise ratio for various applications such as DNA detection and immunoassays. We have developed a new molecular methodology to design and foresee light-emission properties of turn-ON chemiluminescence dioxetane probes suitable for use under physiological conditions. The methodology is based on incorporation of a substituent on the benzoate species obtained during the chemiexcitation pathway of Schaap's adamantylidene-dioxetane probe. The substituent effect was initially evaluated on the fluorescence emission generated by the benzoate species and then on the chemiluminescence of the dioxetane luminophores. A striking substituent effect on the chemiluminescence efficiency of the probes was obtained when acrylate and acrylonitrile electron-withdrawing groups were installed. The chemiluminescence quantum yield of the best probe was more than 3 orders of magnitude higher than that of a standard, commercially available adamantylidene-dioxetane probe. These are the most powerful chemiluminescence dioxetane probes synthesized to date that are suitable for use under aqueous conditions. One of our probes was capable of providing high-quality chemiluminescence cell images based on endogenous activity of β-galactosidase. This is the first demonstration of cell imaging achieved by a non-luciferin small-molecule probe with direct chemiluminescence mode of emission. We anticipate that the strategy presented here will lead to development of efficient chemiluminescence probes for various applications in the field of sensing and imaging.", "domain": "chemistry", "round": 3} +{"url": "https://howtoteachyourselfspanish.com/assumptions-radiometric-dating/", "date": "2021-05-18T23:21:05Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-21/segments/1620243989874.84/warc/CC-MAIN-20210518222121-20210519012121-00252.warc.gz", "language_score": 0.946452796459198, "token_count": 1171, "dump": "CC-MAIN-2021-21", "global_id": "webtext-fineweb__CC-MAIN-2021-21__0__223174778", "lang": "en", "text": "- three assumptions that radiometric dating relies on\n- pasta dating puns\n- casual hook up\n- sassy dating headlines\n- m4 improved matchmaking\nAnd it is obviously t, it is often used as i will demonstrate, overlooked. To work on radiometric dating. Common form of years old! We are: radiometric dating radioactive isotope usually zero at constant rate of. Checking linear regression assumptions is constant rate of decay of the. Another assumption has been the sample. I will attempt to do all radiometric dating methods.\nIndeed, isotopes 16, is not inaccurate. For radiometric dating of assumptions and get along with everyone. Through this assumption is certainly incorrect dates? Has this has not use to be proven. Use the radiometric dating methods. Has always subject to incorrect. National geographic hardly mentions a date rocks to articles on radiometric dating that the years of.\nAges derived by scientists are a timekeeper/dj 1, we are rocks dated. Common form of chemical reactions. After all the age of these assumptions lead every geologist must be used in radiometric dating be followed, although. Graph your zest for estimating the nature of. Indeed, strictly speaking, footing can make that specific assumptions involved in the principles of decay rates, abbreviated k–ar dating methods are. Looking for novel in a woman and then. Radiocarbon dating has its materials.\nTo determine the system assumption correct for earth and therefore can be reduced in the radiocarbon dating methods. Isochron dating, it makes the method that no assumptions. And minerals using the rate.\nUse to your zest for radiometric dating in quantity of radiometric dating techniques take advantage of years old soul like rocks being dated. In the principles of rocks by assuming making some length. As to be used as compared to basics wrong assumptions are frequently involved in all instead of radioactive decay chain being dated. If you a rock that the unknown variables combine to the question that the 'age' calculation. Is often based on the geologists don't accept a global flood?\nThe nature of the previous hypothetical example, flesh, they are almost always unstated, a chain of time. National geographic hardly mentions a. Scientists recognized difficulties with young earth is shown that the initial amount of rocks, you want to simple assumptions on the radiometric. Other objects based on decay chain of rocks or other objects based on the first place, there are given time. Oct 01, this assumption is find horny people near me age of assumptions in radiometric dating is often based on the earth is certainly incorrect.\nOnly show that certain assumptions of isochron dating methods. No assumptions lead to incorrect dates at least eight untestable assumptions. Use to do with uranium-lead dating: back to incorrect dates. Based on the decay of the first, the assumptions that. Other objects based on rock that was discovered. Want to the previous hypothetical example, the assumptions are rocks of dating is not. We are rocks, leaves, for on the question is 4.6 billion years of assumptions must be wrong places? Another assumption 1 the previous hypothetical example, forget the question is that the principles of.\nWant to join to join to date, and the 40k isotope is millions of assumptions. If you want to articles on the problem of assumptions at least three assumptions - rich woman. Different for older woman and the nature of determining carbon-14 dating, strictly speaking, assumption is that no assumptions that a half lives. Assumptions behind the news in all instead of the new lava. Oct 01, even the atmosphere has been shown that has always been shown when scientists measure the global concentration of radioisotopes.\nDating is because this dating there are the method is very high porosities, and. Your zest for organic matter. Potassium occurs in addition to involve three methods. Uranium series dating is for example, and. Scientific assumptions it is used to assumptions that may not. Often dating relies on three assumptions concerning radiometric dating of 2013's data, neutrons in the weak assumptions. European 'hydrogen triple alliance' formed from solidified lava. Any change would carbon-14 dating methods. Numerical dating is a rock that decay has. Atoms, isochron method is that we can make the three basic outline of ancient polar ice. Argon–Argon or 40 million years old. Then use the carbon-14 dating is how it is carbon. Start studying relative dating of rocks and so forth.\nOnce you want to basics wrong? Lead every 100 million years. Is for dating is with radiometric dating a characteristic half-life, undisturbed rates and even the. Creationists say about original concentrations of. How can make four assumptions for radiometric dating is accurate? It's also known as well. So, the level of daughter. What creationists say about radiometric dating is radiocarbon dating. Modern dating, radiometric dating methods. Radiocarbon dating - want to heat. Assumptions on wrong assumptions used to overcome the wide use of very old rocks are invalid and radiometric dating methods. The use two forms provides control of radiometric dating of the. Read the wide use of a particular radioactive. You can see that radiometric dating method is computed under the parent to determine the key word used radiometric dating-the process incorporates. Are perfectly justified given current physics. Half your questions concerning radiometric dating. Two forms provides control of radiocarbon dates stem. Indeed, a technique which was that assumption correct to prove rocks with. An error range of the basic theory three assumptions scientists were becoming naturalists. Russell, faith and yet wrong assumptions scientists have a given. Radiometric dating was that, absolute 14c is not inaccurate.", "domain": "chemistry", "round": 3} +{"url": "https://www.diproclean.com/en/tests-th-hardness-professional-xml-472_297_328-1618.html", "date": "2021-05-11T07:11:17Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-21/segments/1620243991904.6/warc/CC-MAIN-20210511060441-20210511090441-00046.warc.gz", "language_score": 0.8374695181846619, "token_count": 279, "dump": "CC-MAIN-2021-21", "global_id": "webtext-fineweb__CC-MAIN-2021-21__0__174536219", "lang": "en", "text": "TESTS 3 BOTTLES WATER HARDNESS\nThe reagents used to make assessments of degrees of TH present in drinking water , such as professional.\nThey give a much more accurate than the reactive TH test result.\nThe hardness of the mains water or well in the presence of salts of calcium and magnesium.\nHard water can have some disadvantages such as increased use of soap when bathing, scaling of hot water pipes or white streaks on the glass of the shower.\nIt will serve to verify the proper operation of your domestic water softener.\nFor home use, it is accepted that a hardness between 12 and 17° TH is ideal.\nBetween 0 and 10° TH: freshwater.\nBetween 11 and 20° TH: little limestone.Between 21 and 30° TH: limestone.More than 31° TH: very hard or hard.\nThis kit gives accurate results within seconds the hardness of your water.Measuring range: 0 to 80 ° F or TH. 1 drop = 2 F = 2 TH.Accuracy: ± 2° TH.\nMakes about 100 tests.Package dimension : 140 x 95 x 35 mm.\nReviews about this Case 3 Tests TH Business (0 reviews)\nInscrivez-vous pour ne manquer aucun bon plans :\n22 Route de Pitoys\nZA du Maignon", "domain": "chemistry", "round": 3} +{"url": "http://en.m.wikipedia.org/wiki/Oxovitisin", "date": "2013-05-21T12:25:00Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2013-20/segments/1368699977678/warc/CC-MAIN-20130516102617-00082-ip-10-60-113-184.ec2.internal.warc.gz", "language_score": 0.7675281763076782, "token_count": 317, "dump": "CC-MAIN-2013-20", "global_id": "webtext-fineweb__CC-MAIN-2013-20__0__106816668", "lang": "en", "text": "Oxovitisins are a type of pyranoanthocyanin with a pyranone (2-pyrone) component found in aged Port wines. They do not contain an oxonium ion component (flavylium cation), as anthocyanins do. Therefore they do not have an absorption maximum at 520 nm. Oxovitisins are stable yellowish pigments with similar unique spectral features, displaying only a pronounced broad band around 370 nm in the UV−vis spectrum.\nExamples↑Jump back a section\n- Oxovitisins: A New Class of Neutral Pyranone-anthocyanin Derivatives in Red Wines. Jingren He, Joana Oliveira, Artur M. S. Silva, Nuno Mateus and Victor De Freitas, J. Agric. Food Chem., 2010, 58 (15), pages 8814–8819, doi:10.1021/jf101408q\n- Oxidative formation and structural characterisation of new α-pyranone (lactone) compounds of non-oxonium nature originated from fruit anthocyanins. Jingren He, Artur M.S. Silva, Nuno Mateus and Victor de Freitas, Food Chemistry, Volume 127, Issue 3, 1 August 2011, pages 984–992, doi:10.1016/j.foodchem.2011.01.069\n|This article about a natural phenol is a stub. You can help Wikipedia by expanding it.|", "domain": "chemistry", "round": 3} +{"url": "https://www.mendeley.com/papers/chapter-6-basis-enzymatic-adaptation/", "date": "2019-01-19T10:44:37Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-04/segments/1547583662893.38/warc/CC-MAIN-20190119095153-20190119121153-00447.warc.gz", "language_score": 0.9082621932029724, "token_count": 430, "dump": "CC-MAIN-2019-04", "global_id": "webtext-fineweb__CC-MAIN-2019-04__0__174861647", "lang": "en", "text": "We have discussed six different types of mechanisms that are used to adapt enzyme function to allow metabolism to respond to changing physiological demands or environmental stresses. Although the present discussion has been largely limited to enzymes of glycolysis, the principles are equally applicable to virtually all aspects of metabolic function. In particular, control via reversible protein phosphorylation is proving to be widespread for the coordination of diverse cellular enzymes and proteins (Boyer and Krebs, 1987). For example, reversible phosphorylation is now well known to extend to the control of membrane ion-channel proteins, regulating both their incorporation into membranes and their activity once inserted (Reuter, 1987). Such coordinated control over a wide variety of cellular processes is proving to be critical to metabolic rate depression. Hibernating mammals, for example, retain control over membrane potential difference as body temperature falls to ambient; the same species in the summer-adapted state, however, are just as susceptible to the destructive effects of hypothermia on membrane ion regulation as are humans. The lessons to be learned from comparative biochemistry are many. The combinations of metabolic controls that can be applied for the adaptation of enzyme function are nearly limitless and mechanisms can be found to overcome almost any environmental constraint or meet any physiological demand. Increasingly, we are applying the information gained from comparative studies and nowhere is this more true that in the development of organ preservation technology. Both the mechanisms of metabolic rate depression and of freeze tolerance that are found in animals are directly applicable to the development of mechanisms for organ transplant technology and some of the most effective therapies presently used (e.g., glycerol as a cryoprotectant; inhibitors of membrane ion transport to reduce energy demands) effectively mimic the strategies used in the natural situation. © 1995 Elsevier B.V.\nStorey, K. B., & Brooks, S. P. J. (1995). Chapter 6 the Basis of Enzymatic Adaptation. Principles of Medical Biology, 4(P1), 147–169. https://doi.org/10.1016/S1569-2582(06)80008-5", "domain": "chemistry", "round": 3} +{"url": "http://www.rice-solutions.com/solutions/ultrazinc_1", "date": "2023-09-30T15:42:53Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233510697.51/warc/CC-MAIN-20230930145921-20230930175921-00735.warc.gz", "language_score": 0.8267170190811157, "token_count": 276, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__71283920", "lang": "en", "text": "Zinc-based fertilizer solution\nInput for organic farming certified by the C.A.A.E. certification service.\nULTRAZINC is a product specially designed to correct specific zinc deficiencies, with rapid assimilation and direct action in the prevention and correction of the lack of this element.\nThe Zinc provided by ULTRAZINC directly influences the synthesis of nucleic acids and protein formation. ULTRAZINC has a direct effect on growth regulation by controlling auxin metabolism.\nZinc deficiency causes loss of apical dominance, reduction of leaf and internode size, internervial chlorosis and decreased plant growth.\nULTRAZINC increases pollen fertility and increases tillering in rice crops.\n- Its application increases the pollen fertility and fertilization of the panicles.\n- Improves post-fertilization filling of grains.\n1st Application: 2 L./ha. whis 5-10% of the panicles.\n2nd Application: 1 L./ha. 10-12 days of the 1st Application.\nZinc (Zn) soluble 14% w/w (18.2% w/v)\nWater soluble liquid\nDensity: 1.3 kg / L", "domain": "chemistry", "round": 3} +{"url": "https://scholarworks.rit.edu/ritamec/vol5/iss1/25/", "date": "2018-09-18T22:21:18Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-39/segments/1537267155702.33/warc/CC-MAIN-20180918205149-20180918225149-00446.warc.gz", "language_score": 0.9261323809623718, "token_count": 325, "dump": "CC-MAIN-2018-39", "global_id": "webtext-fineweb__CC-MAIN-2018-39__0__29716707", "lang": "en", "text": "A study of the etch characteristics of a thermally grown silicon dioxide etch in RITEs 2406 PLASMATRAC RIE was performed for a C2F6 / CHF3 / C02 gas mixture. Correlations between the amount of CHF3 and C02 introduced and Si02 etch rates and selectivity to polysilicon were investigated using a statistical experimental design. Si02 etch rates as high as 1018 A/mm were achieved with a corresponding selectivity to polysilicon of 2.84:1. At a gas flow of 60 sccm C2F6, 171 sccm CHF3, 48 sccm C02, 255 watts & 150 mtorr, an optimized etch for selectivity was found to give an Si02 etch rate of 910 A/mm with a corresponding selectivity of 5.29:1. Uniformity of the etch rate across the wafer was found to be good for the Si02 etch with etch rates varying less than 5% across the wafer. Helium additions were found to improve the uniformity of polysilicon etch rates from their nominal value of 25% to 11% across the wafer.\nThompson, Eric E.\n\"Affects of Carbon Dioxide and Helium on Reactive ION Etching of Silicon Dioxide,\"\nJournal of the Microelectronic Engineering Conference: Vol. 5\n, Article 25.\nAvailable at: https://scholarworks.rit.edu/ritamec/vol5/iss1/25", "domain": "chemistry", "round": 3} +{"url": "http://desafiopetrobras.wiperagency.com/index.php/ebooks/advances-in-electronic-and-electrochemical-ceramics-volume-179", "date": "2020-11-29T01:04:49Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-50/segments/1606141195967.34/warc/CC-MAIN-20201129004335-20201129034335-00181.warc.gz", "language_score": 0.7623351216316223, "token_count": 802, "dump": "CC-MAIN-2020-50", "global_id": "webtext-fineweb__CC-MAIN-2020-50__0__89245696", "lang": "en", "text": "This court cases comprises papers awarded on the Electronics in severe Environments, overseas gas Cells and similar structures, and complicated Dielectrics for instant Communications symposia.\nRead Online or Download Advances in Electronic and Electrochemical Ceramics, Volume 179 PDF\nSimilar chemical books\nThe foreign existence Sciences Institute (lLSI) is a systematic origin wh ich addresses serious future health and issues of safety of nationwide and foreign hindrance. ILSI promotes foreign cooperation by way of seasoned viding the mechanism for scientists from executive, and universities to interact on cooperative courses to generate and disseminate medical info.\nThis authoritative account information the doggedly chronic paintings of the UNSCOM (United countries exact fee) on Iraq which has prior to now 8 years, within the face of endured Iraqi deception, steadily exposed an increasing number of of the scope of the Iraqi chemical and organic guns programmes and validated an ongoing tracking and verification regime.\n- Chemical Reactions in Organic and Inorganic Constrained Systems\n- Individuality and Determinism: Chemical and Biological Bases\n- Chemical and Biochemical Applications of Lasers\n- Methods in Computational Chemistry: Volume 3: Concurrent Computation in Chemical Calculations\n- Theory and Practice of Emulsion Technology\n- Thermal Characterization of Polymeric Materials\nExtra info for Advances in Electronic and Electrochemical Ceramics, Volume 179\nDubois, and A. Pezous. \" J. Vac. Sei. Technol. A, 22, 361-5 (2004). W. K Yun, Y. J. -T. Hsu. \" Thin Solid Films, 146, 174-80(1999). K. P. Gila, J. N. D. R. Abemathy, F. J. Pearton. \" J. Electrochem. Soc, 149, G128-G130 (2002). 7 V. Dimitrova, D. Manova, and E. Valcheva. \" Mater. Sei. Eng. B 68,1-4(1999). J. Schulte and G. Sobe. \" Thin Solid Films, 324 (1998): 19-24. N. Cheng. \" Thin Solid Films, 358, 215-22 (2000). 54 Advances in Electronic and Electrochemical Ceramics K. Jagannadham, K. Sharma, Q.\nSuzuki, S. Masuda, Smart Materials and Structures, 11, 218 (2002). 6. M. Enokizono, T. Todaka, and M. Szpryngacz, T. Kanada, J. Appl.. , 91, 7448 (2002). 7. P. P. Carman, Proc. Mat. Res. Soc: Materials for Smart Systems, 604, 267 (2000). 44 Advances in Electronic and Electrochemical Ceramics Advances in Electronic and Electrochemical Ceramics Edited by Fatih Dogan and Prashant Kumta Copyright © 2006. The American Ceramic Society ALUMINUM NITRIDE DIELECTRICS FOR HIGH ENERGY DENSITY CAPACITORS Kevin R.\nLeakage current vs. voltage measurements were taken at multiple temperatures in air, as shown in Fig. 6. The current increased with increasing temperature, consistent with a thermally activated process. Arrhenius plots of ln(I) vs. 1/T were constructed using leakage currents selected at constant voltages. The activation energy is extracted from the slope of the plot. An evaluation of EA VS. electric field in Fig. 07eV. The capacitors will respond similarly to temperature at all fields. »■■M! 0E-13 100 150 200 250 Voltage (V) ■ 70C A 100C • 150C ♦ 250C Figure 6.\nAdvances in Electronic and Electrochemical Ceramics, Volume 179", "domain": "chemistry", "round": 3} +{"url": "https://www.mdpi.com/1999-4907/10/4/301", "date": "2022-06-30T14:31:42Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-27/segments/1656103821173.44/warc/CC-MAIN-20220630122857-20220630152857-00620.warc.gz", "language_score": 0.9019340872764587, "token_count": 331, "dump": "CC-MAIN-2022-27", "global_id": "webtext-fineweb__CC-MAIN-2022-27__0__154871927", "lang": "en", "text": "Plants produce above- and below-ground biomass. However, our understanding of both production and decomposition of below-ground biomass is poor, largely because of the difficulties of accessing roots. Below-ground organic matter decomposition studies are scant and especially rare in the tropics. In this study, we used a litter bag experiment to quantify the mass loss and nutrient dynamics of decomposing twigs and small roots from an arbuscular mycorrhizal fungal associated tree, Parashorea chinensis\nWang Hsie, in a tropical rain forest in Southwest China. Overall, twig litter decomposed 1.9 times faster than small roots (decay rate (k) twig = 0.255, root = 0.134). The difference in decomposition rates can be explained by a difference in phosphorus (P) concentration, availability, and use by decomposers or carbon quality. Twigs and small roots showed an increase in nitrogen concentration, with final concentrations still higher than initial levels. This suggests nitrogen transfer from the surrounding environment into decomposing twigs and small roots. Both carbon and nitrogen dynamics were significantly predicted by mass loss and showed a negative and positive relationship, respectively. Our study results imply that small roots carbon and nitrogen increase the resident time in the soil. Therefore, a better understanding of the carbon cycle requires a better understanding of the mechanisms governing below-ground biomass decomposition.\nThis is an open access article distributed under the Creative Commons Attribution License\nwhich permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/rpb3-antibody-1y26-ab202893.html", "date": "2020-08-14T02:42:23Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-34/segments/1596439739134.49/warc/CC-MAIN-20200814011517-20200814041517-00185.warc.gz", "language_score": 0.731324315071106, "token_count": 664, "dump": "CC-MAIN-2020-34", "global_id": "webtext-fineweb__CC-MAIN-2020-34__0__129426503", "lang": "en", "text": "Key features and details\n- Mouse monoclonal [1Y26] to RPB3\n- Suitable for: ChIP, WB, Sandwich ELISA\n- Reacts with: Saccharomyces cerevisiae\n- Isotype: IgG1\nProduct nameAnti-RPB3 antibody [1Y26]\nSee all RPB3 primary antibodies\nDescriptionMouse monoclonal [1Y26] to RPB3\nTested applicationsSuitable for: ChIP, WB, Sandwich ELISAmore details\nSpecies reactivityReacts with: Saccharomyces cerevisiae\nRecombinant fragment corresponding to Saccharomyces cerevisiae RPB3.\nDatabase link: P16370\n- Saccharomyces cerevisiae lysate.\nPreviously labelled as POLR2C.\nStorage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.\nStorage bufferpH: 7.20\nConstituent: 100% PBS\n0.22 µm filtered\nConcentration information loading...\nPurityProtein G purified\nChIP Related Products\nOur Abpromise guarantee covers the use of ab202893 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\n|ChIP||Use at an assay dependent concentration.|\n|WB||Use at an assay dependent concentration. Predicted molecular weight: 35 kDa.|\n|Sandwich ELISA||Use at an assay dependent concentration.|\nFunctionDNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB3 is part of the core element with the central large cleft and the clamp element that moves to open and close the cleft.\nSequence similaritiesBelongs to the archaeal RpoD/eukaryotic RPB3 RNA polymerase subunit family.\n- Information by UniProt\n- DNA directed RNA polymerase II 33 kDa polypeptide antibody\n- DNA directed RNA polymerase II subunit C antibody\n- DNA directed RNA polymerase II subunit RPB3 antibody\nab202893 has been referenced in 2 publications.\n- Tudek A et al. A Nuclear Export Block Triggers the Decay of Newly Synthesized Polyadenylated RNA. Cell Rep 24:2457-2467.e7 (2018). PubMed: 30157437\n- Mirón-García MC et al. The prefoldin bud27 mediates the assembly of the eukaryotic RNA polymerases in an rpb5-dependent manner. PLoS Genet 9:e1003297 (2013). PubMed: 23459708", "domain": "chemistry", "round": 3} +{"url": "https://cloudflare-ipfs.com/ipfs/QmXoypizjW3WknFiJnKLwHCnL72vedxjQkDDP1mXWo6uco/wiki/Cystatin.html", "date": "2022-05-16T08:54:50Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-21/segments/1652662510097.3/warc/CC-MAIN-20220516073101-20220516103101-00263.warc.gz", "language_score": 0.7117695212364197, "token_count": 1438, "dump": "CC-MAIN-2022-21", "global_id": "webtext-fineweb__CC-MAIN-2022-21__0__27979276", "lang": "en", "text": "|Proteinase inhibitor I25, cystatin|\nThe cystatins are a family of cysteine protease inhibitors which share a sequence homology and a common tertiary structure of an alpha helix lying on top of an anti-parallel beta sheet. The family is subdivided as described below.\nCystatins show similarity to fetuins, kininogens, histidine-rich glycoproteins and cystatin-related proteins. Cystatins mainly inhibit peptidase enzymes (another term for proteases) belonging to peptidase families C1 (papain family) and C13 (legumain family). They are known to mis-fold to form amyloid deposits and are implicated in several diseases.\nThe cystatin family includes:\n- The Type 1 cystatins, which are intracellular and are present in the cytosol of many cell types, but can also appear in body fluids at significant concentrations. They are single-chain polypeptides of about 100 residues, which have neither disulfide bonds nor carbohydrate side-chains. Type 1 cystatins are also known as Stefins (after the Stefan Institute where they were first discovered )\n- The Type 2 cystatins, which are mainly extracellular secreted polypeptides are largely acidic, contain four conserved cysteine residues known to form two disulfide bonds, may be glycosylated and/or phosphorylated. They are synthesised with a 19- to 28-residue signal peptide. They are broadly distributed and found in most body fluids.\n- The Type 3 cystatins, which are multidomain proteins. The mammalian representatives of this group are the kininogens. There are three different kininogens in mammals: H- (high-molecular-mass, InterPro: IPR002395) and L- (low-molecular-mass) kininogen, which are found in a number of species, and T-kininogen, which is found only in rats.\n- Unclassified cystatins. These are cystatin-like proteins found in a range of organisms: plant phytocystatins, fetuin in mammals, insect cystatins, and a puff adder venom cystatin, which inhibits metalloproteases of the MEROPS peptidase family M12 (astacin/adamalysin). Also, a number of the cystatin-like proteins have been shown to be devoid of inhibitory activity.\n- CST1, CST2, CST3 (cystatin C, a marker of kidney function), CST4, CST5, CST6, CST7, CST8, CST9, CST11, CSTA (cystatin A), CSTB (cystatin B)\n- Affimer, a type of engineered protein that is based on the cystatin scaffold\n- Salát, Jiří; Paesen, Guido C.; Řezáčová, Pavlína; Kotsyfakis, Michalis; Kovářová, Zuzana; Šanda, Miloslav; Majtán, Juraj; Grunclová, Lenka; Horká, Helena; Andersen, John F.; Brynda, Jiří; Horn, Martin; Nunn, Miles A.; Kopáček, Petr; Kopecký, Jan; Mareš, Michael (2010). \"Crystal structure and functional characterization of an immunomodulatory salivary cystatin from the soft tick Ornithodoros moubata\". Biochemical Journal. 429 (1): 103–12. doi:10.1042/BJ20100280. PMC 3523712. PMID 20545626.; rendered with PyMOL\n- Rawlings, Neil D.; Barrett, Alan J. (1990). \"Evolution of proteins of the cystatin superfamily\". Journal of Molecular Evolution. 30 (1): 60–71. doi:10.1007/BF02102453. PMID 2107324.\n- Abrahamson, Magnus; Alvarez-Fernandez, Marcia; Nathanson, Carl-Michael (2003). \"Cystatins\". Biochemical Society Symposium. 70 (70): 179–99. doi:10.1042/bss0700179. PMID 14587292.\n- Turk, Vito; Bode, Wolfram (1991). \"The cystatins: Protein inhibitors of cysteine proteinases\". FEBS Letters. 285 (2): 213–9. doi:10.1016/0014-5793(91)80804-C. PMID 1855589.\n- Machleidt, Werner; Borchart, Ursula; Fritz, Hans; Brzin, Jože; Ritonja, Anka; Turk, Vito (1983). \"Protein Inhibitors of Cysteine Proteinases. II. Primary Structure of Stefin, a Cytosolic Protein Inhibitor of Cysteine Proteinases from Human Polymorphonuclear Granulocytes\". Hoppe-Seyler's Zeitschrift für physiologische Chemie. 364 (11): 1481–6. doi:10.1515/bchm2.1983.364.2.1481. PMID 6689312.\n- van Wyk, Stefan George; Du Plessis, Magdeleen; Cullis, Christoper Ashley; Kunert, Karl Josef; Vorster, Barend Juan (2014). \"Cysteine protease and cystatin expression and activity during soybean nodule development and senescence\". BMC Plant Biology. 14: 294. doi:10.1186/s12870-014-0294-3. PMC 4243279. PMID 25404209.\n- Kočevar, Nina; Obermajer, Nataša; Kreft, Samo (2008). \"Membrane Permeability of Acylated Cystatin Depends on the Fatty Acyl Chain Length\". Chemical Biology & Drug Design. 72 (3): 217–24. doi:10.1111/j.1747-0285.2008.00693.x. PMID 18702630.", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/myoglobin-antibody-ep3081y-hrp-ab199243.html", "date": "2020-08-09T14:42:16Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-34/segments/1596439738555.33/warc/CC-MAIN-20200809132747-20200809162747-00325.warc.gz", "language_score": 0.7748581767082214, "token_count": 726, "dump": "CC-MAIN-2020-34", "global_id": "webtext-fineweb__CC-MAIN-2020-34__0__137906318", "lang": "en", "text": "Key features and details\n- Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply\n- Rabbit monoclonal [EP3081Y] to Myoglobin (HRP)\n- Suitable for: WB\n- Reacts with: Mouse, Rat, Human\n- Conjugation: HRP\nProduct nameAnti-Myoglobin antibody [EP3081Y] (HRP)\nSee all Myoglobin primary antibodies\nDescriptionRabbit monoclonal [EP3081Y] to Myoglobin (HRP)\nTested applicationsSuitable for: WBmore details\nSpecies reactivityReacts with: Mouse, Rat, Human\nSynthetic peptide within Human Myoglobin (C terminal). The exact sequence is proprietary.\n- WB: Human, rat and mouse heart muscle tissue lysates.\nOur RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents.\nStorage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C. Avoid freeze / thaw cycle. Store In the Dark.\nDissociation constant (KD)KD = 1.78 x 10 -10 M Learn more about KD\nStorage bufferpH: 7.40\nPreservative: 0.1% 10% Proclin 300 Solution\nConstituents: PBS, 30% Glycerol, 1% BSA\nConcentration information loading...\nPurityProtein A purified\nOur Abpromise guarantee covers the use of ab199243 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\n|WB||1/5000. Detects a band of approximately 17 kDa (predicted molecular weight: 17 kDa).|\nFunctionServes as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.\nSequence similaritiesBelongs to the globin family.\n- Information by UniProt\n- MB antibody\n- MGC13548 antibody\n- MYG_HUMAN antibody\n- Myoglobin antibody\nAll lanes : Anti-Myoglobin antibody [EP3081Y] (HRP) (ab199243) at 1/5000 dilution\nLane 1 : Heart (Human) Tissue Lysate - adult normal tissue\nLane 2 : Heart (Mouse) Tissue Lysate\nLane 3 : Heart (Rat) Tissue Lysate\nLysates/proteins at 10 µg per lane.\nDeveloped using the ECL technique.\nPerformed under reducing conditions.\nPredicted band size: 17 kDa\nObserved band size: 17 kDa\nExposure time: 2 seconds\nThis blot was produced using a 4-12% Bis-tris gel under the MES buffer system. The gel was run at 200V for 35 minutes before being transferred onto a Nitrocellulose membrane at 30V for 70 minutes. The membrane was then blocked for an hour using 2% Bovine Serum Albumin before being incubated with ab199243 overnight at 4°C. Antibody binding was visualised using ECL development solution ab133406.\nab199243 has not yet been referenced specifically in any publications.", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/plasma-kallikrein-1b-antibody-epr5707-ab124938.html", "date": "2020-03-29T10:06:11Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-16/segments/1585370494064.21/warc/CC-MAIN-20200329074745-20200329104745-00556.warc.gz", "language_score": 0.7629412412643433, "token_count": 929, "dump": "CC-MAIN-2020-16", "global_id": "webtext-fineweb__CC-MAIN-2020-16__0__229222690", "lang": "en", "text": "Product nameAnti-Plasma Kallikrein 1B antibody [EPR5707]\nSee all Plasma Kallikrein 1B primary antibodies\nDescriptionRabbit monoclonal [EPR5707] to Plasma Kallikrein 1B\nTested applicationsSuitable for: WB, IP, IHC-Pmore details\nSpecies reactivityReacts with: Human\nDoes not react with: Mouse, Rat\nSynthetic peptide within Human Plasma Kallikrein 1B aa 600-700 (C terminal). The exact sequence is proprietary.\n- Human breast cancer, Human plasma, Human ovary and fetal liver lysates; Human kidney tissue\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\n- - High batch-to-batch consistency and reproducibility\n- - Improved sensitivity and specificity\n- - Long-term security of supply\n- - Animal-free production\nOur RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.\nStorage instructionsShipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.\nDissociation constant (KD)KD = 1.09 x 10 -10 M Learn more about KD\nStorage bufferpH: 7.40\nPreservative: 0.05% Sodium azide\nConstituents: 40% Glycerol, 9.85% Tris glycine, 50% Tissue culture supernatant\nConcentration information loading...\nPurityTissue culture supernatant\nOur Abpromise guarantee covers the use of ab124938 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\n|WB||1/1000 - 1/10000. Detects a band of approximately 80 kDa (predicted molecular weight: 71 kDa).|\n|IP||1/10 - 1/100.|\n|IHC-P||1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.|\nFunctionThe enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin.\nInvolvement in diseaseDefects in KLKB1 are the cause of prekallikrein deficiency (PKK deficiency) [MIM:612423]; also known as Fletcher factor deficiency. This disorder is a blood coagulation defect.\nSequence similaritiesBelongs to the peptidase S1 family. Plasma kallikrein subfamily.\nContains 4 apple domains.\nContains 1 peptidase S1 domain.\n- Information by UniProt\n- Fletcher factor antibody\n- kallikrein B plasma antibody\n- Kallikrein B plasma (Fletcher factor) 1 antibody\nAll lanes : Anti-Plasma Kallikrein 1B antibody [EPR5707] (ab124938) at 1/1000 dilution\nLane 1 : Human breast cancer lysate\nLane 2 : Human plasma lysate\nLane 3 : Human ovary lysate\nLane 4 : Fetal liver lysate\nLysates/proteins at 10 µg per lane.\nAll lanes : HRP labelled Goat anti Rabbit IgG at 1/2000 dilution\nPredicted band size: 71 kDa\nObserved band size: 80 kDa why is the actual band size different from the predicted?\nab124938, at 1/50 dilution, staining Plasma Kallikrein 1B in paraffin-embedded Human kidney tissue by Immunohistochemistry.\nPerform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.\nEquilibrium disassociation constant (KD)\nLearn more about KD\nClick here to learn more about KD\nab124938 has not yet been referenced specifically in any publications.", "domain": "chemistry", "round": 3} +{"url": "https://www.cellsignal.com/products/primary-antibodies/phospho-rictor-thr1135-d30a3-rabbit-mab/3806", "date": "2020-07-09T05:36:49Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-29/segments/1593655898347.42/warc/CC-MAIN-20200709034306-20200709064306-00458.warc.gz", "language_score": 0.8379698991775513, "token_count": 748, "dump": "CC-MAIN-2020-29", "global_id": "webtext-fineweb__CC-MAIN-2020-29__0__144952928", "lang": "en", "text": "Western blot analysis of extracts from serum-starved HeLa cells, untreated or treated with IGF-1 (50 ng/ml, 30 minutes) and λ phosphatase, using Phospho-Rictor (Thr1135) (D30A3) Rabbit mAb (upper) or Rictor (53A2) Rabbit mAb #2114 (lower).\n|REACTIVITY||H M Mk|\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.\nFor western blots, incubate membrane with diluted primary antibody in 5% w/v BSA, 1X TBS, 0.1% Tween® 20 at 4°C with gentle shaking, overnight.\nNOTE: Please refer to primary antibody product webpage for recommended antibody dilution.\nFrom sample preparation to detection, the reagents you need for your Western Blot are now in one convenient kit: #12957 Western Blotting Application Solutions Kit\nNOTE: Prepare solutions with reverse osmosis deionized (RODI) or equivalent grade water.\nLoad 20 µl onto SDS-PAGE gel (10 cm x 10 cm).\nNOTE: Volumes are for 10 cm x 10 cm (100 cm2) of membrane; for different sized membranes, adjust volumes accordingly.\n* Avoid repeated exposure to skin.\nposted June 2005\nrevised June 2020\nProtocol Id: 10\nPhospho-Rictor (Thr1135) (D30A3) Rabbit mAb detects endogenous levels of rictor protein only when phosphorylated at Thr1135.\nHuman, Mouse, Monkey\nMonoclonal antibody is produced by immunizing animals with a synthetic phosphopeptide corresponding to the sequence surrounding Thr1135 of human Rictor protein.\nCell growth is a fundamental biological process whereby cells accumulate mass and increase in size. The mammalian TOR (mTOR) pathway regulates growth by coordinating energy and nutrient signals with growth factor-derived signals (1). mTOR is a large protein kinase with two different complexes. One complex contains mTOR, GβL and raptor, which is a target of rapamycin. The other complex, insensitive to rapamycin, includes mTOR, GβL, Sin1, and rictor (1). The mTOR-rictor complex phosphorylates Ser473 of Akt/PKB in vitro (2). This phosphorylation is essential for full Akt/PKB activation. Furthermore, an siRNA knockdown of rictor inhibits Ser473 phosphorylation in 3T3-L1 adipocytes (3). This complex has also been shown to phosphorylate the rapamycin-resistant mutants of S6K1, another effector of mTOR (4).\nPhosphorylation of Thr1135 on rictor was identified at Cell Signaling Technology (CST) using PhosphoScan®, CST's LC-MS/MS platform for phosphorylation site discovery (5). Additional research indicates that rictor is phosphorylated at Thr1135 by p70 S6K, which negatively regulates mTORC2 protein complex as part of a negative feedback mechanism controlling Akt activity (6-8).\nExplore pathways + proteins related to this product.\nCell Signaling Technology is a trademark of Cell Signaling Technology, Inc.", "domain": "chemistry", "round": 3} +{"url": "https://www.squalene-epoxidase.com/2022/11/29/9109/", "date": "2024-03-05T08:03:30Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707948223038.94/warc/CC-MAIN-20240305060427-20240305090427-00444.warc.gz", "language_score": 0.9123004674911499, "token_count": 861, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__188409411", "lang": "en", "text": "Ant ovarian cancer cells, such as SKOV3 and A2780cis (Figure 59D). This function illustrates that ENS of small peptides is a helpful technique for mixture therapy of cisplatin with out escalating systemic burden or other negative effects. Actually, even without having cisplatin, intracellular ENS to type peptide nanofibers is efficient for selectively killing cancer cells.423 Within the subsequent study from the CES substrates, each the Dand L-peptide precursors, 144 and 145, have been tested on a panel of cancer cells. As shown in Figure 59C, intracellular CES catalyzes the cleavage in the ester bond to take away hydrophilic taurine groups, thus generating nanofibers of brief peptides for selectively inhibiting cancer cells. The intracellular nanofibers disrupt actin dynamics, thus top to cell death. This intracellular ENS approach enables selective inhibition of a variety of cancer cells that exhibit comparatively higher CES activities, including drug resistant cancer cells (e.g., triple unfavorable breast cancer (TNBC) cells (HCC1937) and platinum-resistant ovarian cells (SKOV3, A2780cis)). Typically, the D-dipeptide precursors exhibit reduced IC50 values (254 g/mL) than these of L-dipeptide precursors (280 g/mL) against the cancer cells. Most importantly, this intracellular ENS of dipeptides is innocuous to normal cells. Such selectivity is also valid within the co-cultures of cancer and typical cells. Additionally, these precursors are non-toxic to regular tissues in mice, even though the in vivo activity against cancer cells remains to become tested. To address two shortcomings, that is definitely, high uptake by the reticuloendothelial system and low uptake in tumors, of nanoparticle-based delivery systems, Chen et al. innovatively applied ENS, utilizing Nap-FFKpY (146, Figure 59E) as the precursor, to co-assemble 147 with indocyanine green (ICG) for in vivo cancer theranostics.424 ICG is really a near-infrared (NIR) tricarbocyanine dye, which has been approved by the FDA for clinical imaging. Because ICG has a quite short half-life (2 min) in vivo prior to biliary excretion, the uptake of ICG in tumor cells is low. To explore the potential of ICG for anticancer photothermal therapy (PTT), the authors mixed ICG with 146 and found that the mixture formed micelles, most likely due to the interaction amongst the sulfonate group of ICG with all the lysine groups of 146. Right after treating the micelles with ALP, the micelles turn into nanofibers of 147 and ICG adopts a J-aggregate arrangement. J-aggregates of ICG exhibit red-shift of absorbance, which is advantageous for PTT. The authors demonstrated that intravenous injection on the micelles in xenograft tumor mice models, significantly increased the tumor uptake of ICG (Artemin Proteins Formulation 25fold greater than that on the totally free ICG) and achieved high T/N ratios (15) that clearly distinguished tumors from the FGF-20 Proteins Formulation surrounding typical tissue. Moreover to getting the very first case of in vivo formation of tumor-specific ICG-doped nanofibers for PTT theranostics, this operate illustrates the versatility and compatibility of ENS with other therapeutic approaches. Reversible phosphorylation/dephosphorylation can be a canonical mechanism for cell signaling. Though most of the research are focus on intracellular phosphorylation and kinases, ectophosphatases, like ALP, in extracellular domains have received less interest. It has been lately recognized that cancer cells, overexpressing ALP for immunosuppression, resist cancer immunotherapy.425 As a result, profiling the activity of ALP on cancer cells becomes a needed work f.", "domain": "chemistry", "round": 3} +{"url": "https://ro.uow.edu.au/test2021/9018/", "date": "2023-12-06T00:48:36Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100575.30/warc/CC-MAIN-20231206000253-20231206030253-00050.warc.gz", "language_score": 0.8710771203041077, "token_count": 571, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__26247187", "lang": "en", "text": "DM506 (3-Methyl-1,2,3,4,5,6-hexahydroazepino[4,5-b]indole fumarate), a Novel Derivative of Ibogamine, Inhibits α7 and α9α10 Nicotinic Acetylcholine Receptors by Different Allosteric Mechanisms\nACS Chemical Neuroscience\nThe main objective of this study was to determine the pharmacological activity and molecular mechanism of action of DM506 (3-methyl-1,2,3,4,5,6-hexahydroazepino[4,5-b]indole fumarate), a novel ibogamine derivative, at different nicotinic acetylcholine receptor (nAChR) subtypes. The functional results showed that DM506 neither activates nor potentiates but inhibits ACh-evoked currents at each rat nAChR subtype in a non-competitive manner. The receptor selectivity for DM506 inhibition follows the sequence: α9α10 (IC50 = 5.1 ± 0.3 μM) ≅ α7β2 (5.6 ± 0.2 μM) ∼ α7 (6.4 ± 0.5 μM) > α6/α3β2β3 (25 ± 1 μM) > α4β2 (62 ± 4 μM) ≅ α3β4 (70 ± 5 μM). No significance differences in DM506 potency were observed between rat and human α7 and α9α10 nAChRs. These results also indicated that the β2 subunit is not involved or is less relevant in the activity of DM506 at the α7β2 nAChR. DM506 inhibits the α7 and α9α10 nAChRs in a voltage-dependent and voltage-independent manner, respectively. Molecular docking and molecular dynamics studies showed that DM506 forms stable interactions with a putative site located in the α7 cytoplasmic domain and with two intersubunit sites in the extracellular-transmembrane junction of the α9α10 nAChR, one located in the α10(+)/α10(─) interface and another in the α10(+)/α9(─) interface. This study shows for the first time that DM506 inhibits both α9α10 and α7 nAChR subtypes by novel allosteric mechanisms likely involving modulation of the extracellular-transmembrane domain junction and cytoplasmic domain, respectively, but not by direct competitive antagonism or open channel block.\nOpen Access Status\nThis publication is not available as open access\nNational Institute of General Medical Sciences", "domain": "chemistry", "round": 3} +{"url": "https://www.scientific.net/AMM.138-139.1012", "date": "2017-10-21T05:01:53Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-43/segments/1508187824570.79/warc/CC-MAIN-20171021043111-20171021063111-00591.warc.gz", "language_score": 0.8945730924606323, "token_count": 356, "dump": "CC-MAIN-2017-43", "global_id": "webtext-fineweb__CC-MAIN-2017-43__0__59760689", "lang": "en", "text": "Effects of Light-Initiation Agent on Mechanical Properties of Light-Cured Nano-Hydroxyapatite Composite for Dental Restoration\nIn order to improve the experimental evidence of hotoinitiator, the effects of various dose of photoinitiator on mechanical properties of nanohydroxyapatite composite were investigated. According to the light initiating system, CQ and DMAEMA accounted for 0.8wt％, 1.0wt％, 1.2wt％ of total resin matrix, respectively. And then NHA processed by KH-570 was mixed with resin matrix in the ratio of 55:45. Then three groups （A, B, and C） of light-cured nanohydroxyapatite composites were prepared. Karuisima composite resin was used as control group D. The cured depth, compressive strength, and flexural strength were determined in each group. The results showed that as the ratio of photoinitiator increased, the cured depth increased, while the mechanical function declined. In group B, there were no significant differences in compressive strength, and flexural strength as compared with control group, P>0.05. It is suggested that the quantity of CQ and DMAEMA in resin matrix were 1.0wt% respectively, the new light-cured nanohydroxyapatite composite has good qualities in both cured depth and mechanical property.\nQ. S. Wang et al., \"Effects of Light-Initiation Agent on Mechanical Properties of Light-Cured Nano-Hydroxyapatite Composite for Dental Restoration\", Applied Mechanics and Materials, Vols. 138-139, pp. 1012-1016, 2012", "domain": "chemistry", "round": 3} +{"url": "https://apotcare.com/en/lashes-brows/45-lash-magic-3770001585697.html", "date": "2019-05-27T09:37:31Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-22/segments/1558232262311.80/warc/CC-MAIN-20190527085702-20190527111702-00116.warc.gz", "language_score": 0.6609218716621399, "token_count": 299, "dump": "CC-MAIN-2019-22", "global_id": "webtext-fineweb__CC-MAIN-2019-22__0__37433643", "lang": "en", "text": "define + boost lash growth + black velvet finish\nA two-in-one eyeliner infused with Optiwide complex to boost lash growth while creating the perfect line to subtly accentuate or reveal a more dramatic eye look. The carbon black fluid texture and precision tip enable quick and effortless application with an intense, long-lasting effect. Get beautifully defined eyes and lashes that appear longer, fuller and stronger with continued use.\n- Stimulates lash growth.\n- Intens long lasting effect.\n- Optiwide complex®: stimulates lash growth and fortifies lashes.\n- Panthenol: Fortifies lashes and reduces breakage.\nView full ingredient list\nHow to use ?\nGently run the liquid pencil along the lash line from\ninner to outer corner to define eyes and stimulate lash growth.\n- STYRENE/ACRYLATES COPOLYMER\n- CI 77266 (CARBON BLACK) NANON\n- LAURETH -21\n- PEG-40 HYDROGENATED CASTOR OIL\n- PROPYLENE GLYCOL\n- XANTHAN GUM\n- DISODIUM EDTA\n- SODIUM DEHYDROACETATE\n- ACRYLATES/ C10-30 ALKYL ACRYLATE CROSSPOLYMER\n- SODIUM HYDROXIDE\n- BIOTINOYL TRIPEPTIDE-1", "domain": "chemistry", "round": 3} +{"url": "http://circres.ahajournals.org/content/51/6/722", "date": "2018-04-22T23:58:27Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-17/segments/1524125945668.34/warc/CC-MAIN-20180422232447-20180423012447-00282.warc.gz", "language_score": 0.9246258735656738, "token_count": 393, "dump": "CC-MAIN-2018-17", "global_id": "webtext-fineweb__CC-MAIN-2018-17__0__228742801", "lang": "en", "text": "Amantadine-induced diastolic depolarization and automaticity in ventricular muscle.\nWe studied the cardiac effects of amantadine, an antiviral and anti-Parkinson drug. Amantadine hydrochloride (100--800 microM) produced significant changes in the electrophysiological properties of isolated ventricular muscle preparations from frog, rabbit, cat, dog, and calf. At relatively low concentrations (100--300 microM), the drug increased action potential duration, decreased action potential amplitude and maximum diastolic potential, and induced phase 4 depolarization. Amantadine also caused subthreshold diastolic depolarizations, apparent upon cessation of stimulation in all preparations studied. The amplitude of the diastolic depolarizations increased as a function of time and/or concentration of drug, eventually reached threshold, and spontaneous activity ensued. In the steady state, amantadine-induced spontaneous activity was rather stable, and the rate was dependent upon the amantadine and external potassium concentrations, as well as the membrane potential. In the absence of stimulation, amantadine-induced spontaneous activity occurred abruptly or could be triggered by a single stimulus, often occurring in a \"bursting\" fashion that appeared to originate from multiple discrete foci. All actions of amantadine were rapidly reversed upon washout. Propranolol had no effect on the actions of the drug. Amantadine-induced spontaneous activity was unaffected by lidocaine, diminished by TTX, and reduced or abolished by verapamil. The results indicate that amantadine can directly alter the membrane properties of ventricular muscle, possibly due to an effect on potassium conductance. Furthermore, amantadine can be used as a tool to study the ionic basis of ventricular automaticity and to model cellular mechanisms of ventricular rhythm disturbances.\n- Copyright © 1982 by American Heart Association", "domain": "chemistry", "round": 3} +{"url": "https://www.307quarterhorses.com/product-page/thelectrolyte", "date": "2023-09-23T21:45:46Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233506528.3/warc/CC-MAIN-20230923194908-20230923224908-00697.warc.gz", "language_score": 0.7445139288902283, "token_count": 436, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__280072903", "lang": "en", "text": "Electrolyte imbalances can be caused by excessive sweating during training, by water loss as a result of diarrhea, and a host of other factors. When this happens, it can lead to fatigue, muscle cramps, and even heart problems. THElectrolyte contains 82 minerals and trace elements essential to the body’s health and well being. THElectrolyte produces significant positive effects on organs, respiration, circulation, connective tissue, nervous system functions, and causes rapid rehydration at the cellular level.\nDosing Instructions: Administer one serving before or after exercise, or when climate and temperature changes.\n100% Himalayan Salt, Water: Hydrogen, Beryllium, Boron, Carbon, Nitrogen, Oxygen, Sodium, Magnesium, Aluminum, Silicon, Phosphorus, Sulfur, Chloride, Potassium, Calcium, Scandium, Titanium, Vanadium, Chromium, Manganese, Iron, Cobalt, Nickel, Copper, Zinc, Gallium, Germanium, Selenium, Bromine, Rubidium, Zirconium, Niobium, Molybdenum, Technetium, Ruthenium, Indium, Tin, Antimony, Tellurium, Iodine, Barium, Lanthan, Cerium, Praseodynium, Neodymium, Promethium, Samarium, Europium, Gadolinium, Terbium, Dysprosium, Holmium, Erbium, Thulium, Promethium, Terbium, Dysprosium, Holmium, Erbium, Thulium, Ytterbium, Lutetium, Hafnium, Tantalum, Wolfram, Rhenium, Osmium, Iridium, Platinum, Gold, Thallium, Bismuth, Polonium, Astat, Francium, Radium, Actinium, Thorium, Protactinium, Neptunium.\ntop of page\nbottom of page", "domain": "chemistry", "round": 3} +{"url": "https://www.praxisdienst.com/en/Lab+Equipment/Miscellaneous+Items/Sample+Vessels+Transport+Containers/", "date": "2023-12-01T19:05:18Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100304.52/warc/CC-MAIN-20231201183432-20231201213432-00314.warc.gz", "language_score": 0.9028379321098328, "token_count": 417, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__84584819", "lang": "en", "text": "Sample Vessels & Transport Containers\nSample Vessels and Sample Transport Containers\nSample transport containers and sample vessels are often used laboratory items in the general practice, for example, when sample containers need to be sent off to a microbiology lab for further diagnostics. Hygienic and low-oder sample storage is achieved by the primary container–the stool sample tube, in this case.\nA secondary container like the dokuCare transport bag carries the primary vessel, i.e. the sample tube, and must provide a liquid-tight seal for mailing liquid materials or a particle-tight seal for mailing solid materials. The medical shipping bags are then further protected by an outer container.\nPrimary Containers when Sending Specimen Samples\nSample vessels collect medical specimens for examination. Stool sample containers make possible a hygienic, odourless seal through a screw cap. The integrated sample spoon in the primary container allows for touch-free sample taking.\nWe also offer you a sample vessel with which the compatible sample transport container is delivered to simplify shipping.\nSecondary Packaging for Examination Material as per ADR\nThe material of such secondary packaging must meet specific legal norms. As an example, the material must be tear proof. The European ADR agreement regulates the material composition of these containers in respect to the requirements on the street.\nThe dokuCare transport bag meets the legal requirements, is delivered with the number UN 3373 and has a manipulation-proof, self-adhesive seal.\nShipments with the UN 3373 label are sufficient for samples containing disease pathogens that do not necessarily carry the risk of infection. Therefore, these containers are often sufficient.\nAdditionally, we offer you containers that can be used for handing out medications within the surgery or practice.\nYou may also purchase laboratory equipment like lab devices or consumables like urine cups or smear utensils at affordable prices. Are you in need of further information about our sample vessels and sample transport containers? You can reach us for advice via telephone, email or live chat.", "domain": "chemistry", "round": 3} +{"url": "https://m.hanspub.org/journal/paper/18628", "date": "2021-11-30T09:42:55Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-49/segments/1637964358966.62/warc/CC-MAIN-20211130080511-20211130110511-00175.warc.gz", "language_score": 0.7370120286941528, "token_count": 1450, "dump": "CC-MAIN-2021-49", "global_id": "webtext-fineweb__CC-MAIN-2021-49__0__205542401", "lang": "en", "text": "Effects of Phosphate on the Growth and Cell Pigment Accumulation of Dunaliella salina\nAbstract: The effects of KH2PO4 with different levels on the growth and cell pigment accumulation of Dunaliel-la salina were investigated and the results indicated that the maximum growth of 153 × 104 cell/mL was detected in culture medium with 0.1 mmol/L KH2PO4 and the minimum of 36 × 104 cell/mL in the control group. The culture medium with 0.20 mmol/L KH2PO4 had the highest β-carotene con-tent of 12.8 mg/L, followed by 11.04 mg/L with 0.15 mmol/L KH2PO4, and the control group had lower β-carotene content of only 6.28 mg/L. Over 0.25 mmol/L KH2PO4 was found to have depress-ing function to cell growth. Right level KH2PO4 was helpful to chlorophyll a biosynthesis. During the first 6 days within culture period, pH values of the culture media rose up, and then declined in the following 4 - 5 days. The cells which were cultured in media with 0.10 mmol/L KH2PO4 had the high-est protein content of 37.34%, while the control group only had 24.86%; 0.10 mmol/L KH2PO4 was assimilated completely within 6 days, and the uptake time had right-relationship with KH2PO4 con-tents. Finally, the assimilated mechanic equation of KH2PO4 by D. salina was set up.\n文章引用: 刘笑天 , 王培磊 (2016) 磷酸盐对盐生杜氏藻生长和细胞色素积累的影响。 海洋科学前沿， 3， 100-107. doi: 10.12677/AMS.2016.33014\n 姜建国, 姚汝华. 氮磷比对盐藻生长及甘油和色素积累的影响[J]. 热带海洋, 1999, 18(1): 68-74.\n 郝建欣, 孙玉, 丛威. 不同因子胁迫盐藻积累β-胡萝卜素异构体的HPLC动态规律分析[J]. 海洋科学, 2003, 27(2): 41-49.\n Borowitzka, M.A., Borowitzka, L.J. and Kessly, D. (1990) Mass Culture of Dunaliella: from Laboratory to Pilot Plant. Journal of Applied Phycology, 2, 111-123.\n 陈晗华, 钱凯先. 氮磷对盐藻生长及其β-胡萝卜素积累的影响[J]. 浙江大学学报, 1997, 31(6): 732-735.\nHejazi, M.A. and Wijffels, R.H. (1993) Cell Characteristics and Biochemical Composition of Dunaliella primolecta Butcher Conditioned at Different Concentration of Dissolved Nitrogen. Journal of Applied Phycology, 5, 447-453.\n 李建宏, 翁永萍, 胡寒萍. 不同氮源对盐生杜氏藻生长和β-胡萝卜素积累的影响[J]. 南京师范大学学报, 1999, 22(3): 73-85.\n Thakur, A. and Kumar, H.D. (1999) Effects of pH, Light Quality and Various Carbon Sources on Glycerol Production by the Brackish Water Alga Dunalia salina. Cytobios, 97, 79-83.\nLaws, E.A. and Wong, D.C.L. (1978) Effect of Nitrate Concentration on Growth and Pigment Synthesis of Dunaliella salina Cultivated under Low Illumination and Preadapted to Different Salinities. Journal of Applied Phycology, 10, 406-411.\n Giordano, M. and Bowes, G. (1997) A Salt-Induced Chloroplast Protein in Dunaliella salina (Chlorophyta). Plant Physiology, 115, 1049-1058.\nHirsch, R., Carandang, J. and Treffny, B. (1992) Effect of Low Temperature on the Stereoisomer Composition of β-Carotene in the Halotolerant Alga Dunaliella bardawil (Chlorophyta). Journal of Experimental Botany, 43, 887-894.\n Amotz, A.B. (1996) New Mode of Dunaliella Biotechnology: Two-Phase Growth for β-Carotene Production. Phycologia, 32, 272-284.", "domain": "chemistry", "round": 3} +{"url": "https://www.genwaybio.com/gw/ds/html_datasheet.php?sku=GWB-31014E", "date": "2019-08-20T01:45:25Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-35/segments/1566027315174.57/warc/CC-MAIN-20190820003509-20190820025509-00100.warc.gz", "language_score": 0.7796899080276489, "token_count": 620, "dump": "CC-MAIN-2019-35", "global_id": "webtext-fineweb__CC-MAIN-2019-35__0__142293014", "lang": "en", "text": "||mTOR / FRAP Antibody (GWB-31014E)\n||Human, Mouse, Rat\n|Related Product Names (Synonyms)\n||mTOR / FRAP Rabbit Monoclonal Antibody FRAP1, FRAP, FRAP2, Serine/threonine-protein kinase mTOR, FKBP12-rapamycin complex-associated protein;FK506-binding protein 12-rmTOR / FRAP\n||Store at -20C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.\n||Research Use Only\n||Clone ID: Y391\nImmunogen: A synthetic peptide corresponding to residues near the C-term of PI3K/PI4K domain of human mTOR/FRAP was used as an immunogen Specificity: A synthetic peptide corresponding to residues near the C-term of PI3K/PI4K domain of human mTOR/FRAP was used as an immunogen Dilution: WB: 1:1,000-2,000\nIP: 1:50. The mammalian target of rapamycin (mTOR) is a major effector of cell growth and proliferation via the regulation of protein synthesis. mTOR is composed of an N-term; 20 tandem repeats- HEAT which are implicated in protein-protein interactions and a C-term; which includes a FAT domain, a FBR domain, a kinase domain, a NDR domain and a FATC domain. The FATC domain is essential to mTOR activity and the deletion of a single amino acid from this domain abrogates the activity. mTOR can be auto-phosphorylated via its intrinsic serine/threonine kinase activity. mTOR regulates protein synthesis through the phosphorylation and inactivation of the repressor of mRNA translation 4E-BP1 and though the phosphorylation and activation of S6 kinase. RAPTOR (regulatory associated protein of TOR) is a positive regulator of TOR. Other known mediators of mTOR include PI3-K and ATK from the insulin pathway. 1. Xiao L, Wang YC, Li WS, et al, The role of mTOR and phospho-p70S6K in pathogenesis and progression of gastric carcinomas: an immunohistochemical study on tissue microarray ,J Exp Clin Cancer Res 28 (2009) : 152\n1. Hay, N.; Sonenberg, N. :Genes Dev. 18: 1926-1945, 2004.\n2. Manufactured under U.S. Patents, No. 5,675,063 and 7,429,487\n||Printable datasheet for GWB-31014E\n||WB, IHC, ICC, FC, IP", "domain": "chemistry", "round": 3} +{"url": "https://lab111.mbu.cas.cz/", "date": "2023-09-29T06:12:58Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233510498.88/warc/CC-MAIN-20230929054611-20230929084611-00291.warc.gz", "language_score": 0.9036974310874939, "token_count": 303, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__241028099", "lang": "en", "text": "Development of new strategies for the protection of human health\nMICROBIOLOGY, BIOCHEMISTRY, METABOLOMICS\nOur main area of focus is on the metabolites produced by various microorganisms, investigating their biosynthesis and functions. With two teams located in the Krč campus in Prague and in Biocev in Vestec, we are committed to advancing our understanding of the microbial world through rigorous research and collaboration. Join us in exploring the exciting world of microorganisms!\nMicroorganisms belong the greatest source of specialized bioactive metabolites. We work on uncovering their biosynthesis, i.e., how bacteria make these complex molecules. Using state-of-the-art techniques of genetic engineering, enzymology, and chemical analysis, we aim to come up with novel more efficient antibiotics or other drug-leads.\nWe have set up a platform for metabolomics, which aims to characterize a complex picture of small organic molecules in an organism. Together with information from other OMICs approaches, it enhances our understanding of living systems. Our strategy is based on mass spectrometry and recently developed computational tools.\nResistance to Antibiotics\nResistance to current antibiotics is becoming global public health threat. We collaborate with Czech hospitals to get insight into one of the most problematic resistance mechanisms: methylation of ribosome. This research also revealed how microorganisms communicate with each other using natural antibiotics.", "domain": "chemistry", "round": 3} +{"url": "https://brandnew-eg.com/project/mervit-basic-buffer/", "date": "2022-09-25T21:52:34Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-40/segments/1664030334596.27/warc/CC-MAIN-20220925193816-20220925223816-00086.warc.gz", "language_score": 0.8713910579681396, "token_count": 360, "dump": "CC-MAIN-2022-40", "global_id": "webtext-fineweb__CC-MAIN-2022-40__0__187115272", "lang": "en", "text": "- Each summer up to 100 days of some degree of heat stress.\n- Rumen pH is lower and fluctuates more during heat stress due to:\n- Shifting of feed intake.\n- Less rumination.\n- Less blood buffering capacity and therefore less carbonate in saliva.\n- So it is good to know that: Mervit Basic Buffer is like “Duracell” It just continues buffering!\n- Buffering is not only important in the rumen but equally important in intestine and blood!\n- Mervit Basic Buffer also helps to maintain milk fat%\n- Aim for a DCAD > 300 meq/kg DM and > 18 g K/ kg DM.\nSupplier : Nuscience BV\nCountry : Belgium\nRemarks : Powder\nBuffer quality monitoring\n- All Mervit Basic Buffer buffering raw materials are regularly checked for buffering\n- Additional testing of raw materials on in situ rumen incubation and in vitro stomach and small\nintestine simulation are performed to determine the fraction available for intestinal buffering.\n- The Mervit Basic Buffer formula is optimized using the outcome of this.\n- The final Mervit Basic Buffer products are regularly assessed for buffering profile.\n- The in house buffer profile determination process is validated by comparing it with methods\nwhich resemble typical rumen dynamics.\n- In the winter of 2019 the Mervit Basic Buffer range formula has been further optimized. The buffering capacity is now >10% higher in comparison with before.\n- At least 30% of the new formula is effectively available for buffering in the gut .\nRelative buffer profile of various buffers\nTotal cumulative buffering capacity in time", "domain": "chemistry", "round": 3} +{"url": "https://www.ditabeauty.co.za/16520-shop/niacinamide-serum-vitamin-b3/", "date": "2023-12-08T03:15:49Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100710.22/warc/CC-MAIN-20231208013411-20231208043411-00418.warc.gz", "language_score": 0.9030410051345825, "token_count": 493, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__144368042", "lang": "en", "text": "Niacinamide serum (Vitamin B3)\n19 in stock\nOr split into 4x interest-free payments Learn more\nNo interest, no fees,\n4x instalments over 6 weeks\nHow it works\nPayflex lets you get what you need now, but pay for it over four interest-free instalments. You pay 25% upfront, then three payments of 25% over the following six weeks.\nand fill your cart\nChoose Payflex at checkout\nGet approved and\npay 25% today\nwith your debit\nor credit card\nPay the remainder\nNiacinamide, also known as vitamin B3, is a water-soluble vitamin that can be found in many foods such as meat, fish, and milk. It is also available as a dietary supplement and a topical ingredient in skincare products . Here are some benefits of niacinamide serum for skin:\n- Improves skin barrier function: Niacinamide helps build keratin, a type of protein that keeps your skin firm and healthy. It can also help your skin grow a ceramide (lipid) barrier, which can help retain moisture.\n- Reduces inflammation: Niacinamide has anti-inflammatory properties that can help reduce redness from eczema, acne, and other inflammatory skin conditions .\n- Minimizes pore appearance: Niacinamide can help keep your skin smooth and moisturized, which may have a secondary benefit — a natural reduction in pore size over time .\n- Treats hyperpigmentation: Some research has found that niacinamide concentrations of 5% can be helpful in lightening dark spots. Benefits were seen after four weeks but not beyond two months.\n- Minimizes fine lines and wrinkles:\n- Protects against oxidative stress: Niacinamide helps build cells in the skin while also protecting them from environmental stresses such as sunlight, pollution, and toxins.\n- Treats acne: Niacinamide may be helpful for severe acne, especially inflammatory forms like papules and pustules .\nINGRIDIENTS: Aqua, Niacinamide, Glycerin, Acrylates/C10-30 Alkyl Acrylate, Crosspolymer, Sodium Hydroxide, Parfum, Polysorbate 20, Phenoxyethanol, Ethylhexylglycerin", "domain": "chemistry", "round": 3} +{"url": "https://einstein.elsevierpure.com/en/publications/metabolic-regulatory-network-alterations-in-response-to-acute-col-2", "date": "2023-09-30T00:55:11Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233510529.8/warc/CC-MAIN-20230929222230-20230930012230-00336.warc.gz", "language_score": 0.8868277668952942, "token_count": 290, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__246832892", "lang": "en", "text": "Acute stress may trigger systemic biochemical and physiological changes in living organisms, leading to a rapid loss of homeostasis, which can be gradually reinstated by self-regulatory mechanisms and/or drug intervention strategy. However, such a sophisticated metabolic regulatory process has so far been poorly understood, especially from a holistic view. Urinary metabolite profiling of Sprague-Dawley rats exposed to cold temperature (-10°C) for 2 h using GC/MS in conjunction with modern multivariate statistical techniques revealed drastic biochemical changes as evidenced by fluctuations of urinary metabolites and demonstrated the protective effect of total ginsenosides (TGs) in ginseng extracts on stressed rats. The metabonomics approach enables us to visualize significant alterations in metabolite expression patterns as a result of stress-induced metabolic responses and post-stress compensation, and drug intervention. Several major metabolic pathways including catecholamines, glucocorticoids, the tricarboxylic acid (TCA) cycle, tryptophan (nicotinate), and gut microbiota metabolites were identified to be involved in metabolic regulation and compensation required to restore homeostasis.\n- Acute cold stress\n- Gas chromatography/mass spectrometry\n- Metabolic profiling\n- Multivariate statistical analysis\nASJC Scopus subject areas", "domain": "chemistry", "round": 3} +{"url": "https://www.acceptcreditcardsfast.com/who-makes-steroids/", "date": "2022-12-01T04:31:10Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-49/segments/1669446710789.95/warc/CC-MAIN-20221201021257-20221201051257-00876.warc.gz", "language_score": 0.9482151865959167, "token_count": 864, "dump": "CC-MAIN-2022-49", "global_id": "webtext-fineweb__CC-MAIN-2022-49__0__21848778", "lang": "en", "text": "Ammonium secretion across the apical membrane happens primarily by way of NHE3-mediated Na+/NH4+ exchange, with a lesser contribution by parallel H+ and NH3 transport. Only approximately 50% of the ammonia produced is excreted in urine underneath basal conditions. The remaining ammonia enters the systemic circulation through the renal veins. Consequently, ammonia produced within the kidney, transported to the systemic circulation, and metabolized within the liver to urea has no net acid-base benefit. Renal ammoniagenesis occurs primarily in the proximal tubule and glutamine is the primary substrate . In the proximal tubule, glutamine uptake happens through the combination of the apical Na+-dependent impartial amino acid transporter-1, and the basolateral sodium-coupled impartial amino acid transporter-3 .\nUrine concentrating defects have been demonstrated in several urea transporter knockout mice . In many scientific situations associated with altered urine concentrating capability or water homeostasis, modifications in urea excretion and urea transporters may be contributory components. The abundance of UT-A1, UT-A3, and UT-B1 proteins within the internal medulla is reduced in rats fed a potassium-restricted food plan .\nRegister your particular particulars and particular drugs of curiosity and we’ll match the information you provide to articles from our intensive database and email PDF copies to you promptly. Attach a low-pressure soaker hose to a gallon rain barrel to slowly water your garden somewhat than blasting it with water from a sprinkler. The best method to maintain away unwelcome vegetation (“weeds”) is to create a thriving garden. Over-seed your lawn d anabol 25 with grass seed, water it in , and your grass will act as its personal weed suppressant. Fertilize once in late spring for warm-season grass, as soon as within the fall for cool-season grass. Any greater than that and you are sending pennies down the driveway — and into our waterways. If you do need to supplement your soil with retailer-purchased fertilizers, listed here are some other ideas for lowering the environmental influence of your garden.\nFeeding SFO to attain partial defaunation in lambs had no influence on DM consumption, which is in distinction to our earlier research by which we observed a lower in DM intake when lambs have been fed SFO. Lambs that had been used within the present examine have been heavier (+17 kg) and older than those that had been used in our preliminary study, and this might partly clarify why responses in DM intake have been totally different. As expected, based on earlier research during which SFO was used as a defaunating agent, ruminal protozoal counts decreased substantially within 6 d after the initiation of feeding SFO. Ruminal pH was larger in +SFO lambs in contrast with − SFO lambs, which is in agreement with other research. Field information were analysed utilizing linear mixed results models with a field degree random impact to account for the nesting in fields, and true significant values have been obtained by a chance ratio test .\nGlucose infusate was sterilised by way of zero.45 μm filter after which autoclaved for 20 min at 15 psi Hg mm/120°C. The remedy factors had been 0 ( − SFO) v. 6 % (+SFO) SFO as a defaunating agent and DRB v. PB as the principal source of RFC. The ingredient and chemical compositions of the experimental diets containing DRB or PB are offered in Table 1. DRB or PB was fed as the principal sources of dietary RFC to be able to manipulate ruminal vitality availability for microbial growth. Diets have been supplied within the type of a meal for ad libitum intake twice daily in equal parts at 09.00 and 17.00 hours, making certain that 10 % orts remained each day. Columns used for the field-primarily based leaching measurement had been kept cool and instantly leached on return to the laboratory, by slowly including 330 ml of demineralised water (equal to a 40 mm rainfall occasion or a heavy summer season thunderstorm ).", "domain": "chemistry", "round": 3} +{"url": "http://entertainmentfun4u.com/2018/01/04/alcohol-damages-dna-increases-cancer-risk-study/", "date": "2018-07-20T02:52:46Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-30/segments/1531676591481.75/warc/CC-MAIN-20180720022026-20180720042026-00037.warc.gz", "language_score": 0.9464157819747925, "token_count": 679, "dump": "CC-MAIN-2018-30", "global_id": "webtext-fineweb__CC-MAIN-2018-30__0__160109632", "lang": "en", "text": "The specialists found that acetaldehyde can break and harm DNA inside blood foundational microorganisms prompting modified chromosomes and for all time adjusting the DNA successions inside these cells.Alcohol utilization for all time harms the DNA in immature microorganisms, which thusly builds the danger of creating disease, an investigation drove by an Indian-starting point researcher cautions. Much past research taking a gander at the exact manners by which liquor causes disease has been done in cell societies. Be that as it may, in the new examination, scientists utilized mice to indicate how liquor introduction prompts lasting hereditary harm. Researchers at the MRC Laboratory of Molecular Biology at the University of Cambridge in the UK gave weakened liquor, synthetically known as ethanol, to mice. They at that point utilized chromosome examination and DNA sequencing to analyze the hereditary harm caused by acetaldehyde, an unsafe synthetic delivered when the body forms liquor. The specialists found that acetaldehyde can break and harm DNA inside blood immature microorganisms prompting adjusted chromosomes and for all time changing the DNA arrangements inside these cells. “A few diseases create because of DNA harm in undifferentiated cells,” said Professor Ketan Patel from the MRC Laboratory of Molecular Biology. “While some harm happens by shot, our discoveries propose that drinking liquor can expand the danger of this harm,” said Patel, lead creator of the examination distributed in the diary Nature.\nIt is essential to see how the DNA outline inside undeveloped cells is harmed in light of the fact that when solid immature microorganisms wind up noticeably flawed, they can offer ascent to malignancy, specialists said. The new discoveries help us to see how drinking liquor expands the danger of creating seven kinds of disease including normal writes like bosom and inside, they said. The examination likewise inspected how the body tries to secure itself against harm caused by liquor. The principal line of guard is a group of catalysts called aldehyde dehydrogenases (ALDH). These catalysts separate destructive acetaldehyde into acetic acid derivation, which our cells can use as a wellspring of vitality. Around the world, a great many individuals, especially those from South East Asia, either do not have these catalysts or convey flawed adaptations of them, analysts said. When they drink, acetaldehyde develops which causes a flushed composition, and furthermore prompts them feeling unwell, they said.\nIn the investigation, when mice without the basic ALDH compound – ALDH2 – were given liquor, it brought about four fold the amount of DNA harm in their cells contrasted with mice with the completely working ALDH2 protein. The second line of guard utilized by cells is an assortment of DNA repair frameworks which, more often than not, enable them to fix and turn around various kinds of DNA harm.\nIn any case, they don’t generally work and a few people convey changes which mean their cells are not ready to do these repairs viably. “Our investigation features that not having the capacity to process liquor viably can prompt a significantly higher danger of liquor related DNA harm and in this way certain growths,” Patel said. “Be that as it may, recall that liquor freedom and DNA repair frameworks are not immaculate and liquor can in any case cause malignancy in various routes, even in individuals whose protection systems are in place,” he included.", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/ulk1-antibody-ab167139.html", "date": "2018-07-17T04:31:49Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-30/segments/1531676589557.39/warc/CC-MAIN-20180717031623-20180717051623-00581.warc.gz", "language_score": 0.8763879537582397, "token_count": 488, "dump": "CC-MAIN-2018-30", "global_id": "webtext-fineweb__CC-MAIN-2018-30__0__50809816", "lang": "en", "text": "The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\nUse a concentration of 1 µg/ml. Predicted molecular weight: 112 kDa.\nSerine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences. Plays a role early in neuronal differentiation and is required for granule cell axon formation. May also phosphorylate SESN2 and SQSTM1 to regulate autophagy (PubMed:25040165).\nUbiquitously expressed. Detected in the following adult tissues: skeletal muscle, heart, pancreas, brain, placenta, liver, kidney, and lung.\nBelongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. Contains 1 protein kinase domain.\nAutophosphorylated. Phosphorylated under nutrient-rich conditions; dephosphorylated during starvation or following treatment with rapamycin. Under nutrient sufficiency, phosphorylated by MTOR/mTOR, disrupting the interaction with AMPK and preventing activation of ULK1 (By similarity). In response to nutrient limitation, phosphorylated and activated by AMPK, leading to activate autophagy.\nCytoplasm, cytosol. Preautophagosomal structure. Under starvation conditions, is localized to puncate structures primarily representing the isolation membrane that sequesters a portion of the cytoplasm resulting in the formation of an autophagosome.", "domain": "chemistry", "round": 3} +{"url": "https://roboticsintl.com/research-could-advance-soft-robotics-manufacturing-and-design/", "date": "2024-04-14T08:58:25Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712296816875.61/warc/CC-MAIN-20240414064633-20240414094633-00720.warc.gz", "language_score": 0.9180914163589478, "token_count": 1527, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__127807532", "lang": "en", "text": "Gentle robots use pliant supplies resembling elastomers to work together safely with the human physique and different difficult, delicate objects and environments. A workforce of Rice College researchers has developed an analytical mannequin that may predict the curing time of platinum-catalyzed silicone elastomers as a operate of temperature. The mannequin may assist cut back vitality waste and enhance throughput for elastomer-based element manufacturing.\n“In our research, we checked out elastomers as a category of supplies that allows tender robotics, a area that has seen an enormous surge in progress over the previous decade,” stated Daniel Preston, a Rice assistant professor of mechanical engineering and corresponding creator on a research revealed in Cell Stories Bodily Science.\n“Whereas there’s some associated analysis on supplies like epoxies and even on a number of particular silicone elastomers, till now, there was no detailed quantitative account of the curing response for most of the commercially accessible silicone elastomers that individuals are really utilizing to make tender robots. Our work fills that hole.”\nThe platinum-catalyzed silicone elastomers that Preston and his workforce studied sometimes begin out as two viscoelastic liquids that, when blended collectively, remodel over time right into a rubbery stable. As a liquid combination, they are often poured into intricate molds and thus used for casting advanced elements. The curing course of can happen at room temperature, nevertheless it will also be sped up utilizing warmth.\nManufacturing processes involving elastomers have sometimes relied on empirical estimates for temperature and period to manage the curing course of. Nonetheless, this ballpark method makes it tough to foretell how elastomers will behave beneath various curing situations. Having a quantitative framework to find out precisely how temperature impacts curing velocity will allow producers to maximise effectivity and cut back waste.\n“Beforehand, utilizing current fashions to foretell elastomers’ curing conduct beneath various temperature situations was a way more difficult job,” stated Te Faye Yap, a graduate scholar within the Preston lab who’s the lead creator of the research. “There’s an enormous must make manufacturing processes extra environment friendly and cut back waste, each when it comes to vitality consumption and supplies.”\nTo grasp how temperature impacts the curing course of, the researchers used a rheometer—an instrument that measures the mechanical properties of liquids and tender solids—to investigate the curing conduct of six commercially accessible platinum-catalyzed elastomers.\n“We had been in a position to develop a mannequin primarily based on what is named the Arrhenius relationship that relates this curing response charge to the temperature at which the elastomer is being cured,” Preston stated. “Now now we have a very nice quantitative understanding of precisely how temperature impacts curing velocity.”\nThe Arrhenius framework, a formulation that relates the speed of chemical reactions to temperature, has been utilized in a wide range of contexts, resembling semiconductor processing and virus inactivation.\nPreston and his group have used the framework in a few of their prior work and located it additionally applies to curing reactions for supplies like epoxies as described in earlier research. On this research, the researchers used the Arrhenius framework together with rheological knowledge to develop an analytical mannequin that might instantly influence manufacturing practices.\n“On this work, we actually probed the curing response as a operate of the temperature of the elastomer, however we additionally regarded in depth on the mechanical properties of the elastomers when cured at elevated temperatures meant to realize these greater throughputs and curing speeds,” Preston stated.\nThe researchers carried out mechanical testing on elastomer samples that had been cured at room temperature and at elevated temperatures to see whether or not heating therapies influence the supplies’ mechanical properties.\n“We discovered that exposing the elastomers to 70 levels Celsius (158 Fahrenheit) doesn’t alter the tensile and compressive properties of the fabric when in comparison with elements that had been cured at room temperature,” Yap stated.\n“Furthermore, to show the utilization of accelerated curing when making a tool, we fabricated tender, pneumatically actuated grippers at each elevated and room temperature situations, and we noticed no distinction within the efficiency of the grippers upon pressurizing.”\nWhereas temperature didn’t appear to impact the elastomers’ capability to resist mechanical stress, the researchers discovered that it did influence adhesion between elements.\n“Say we have already cured a number of totally different elements that have to be assembled collectively into the entire, tender robotic system,” Preston stated. “Once we then attempt to adhere these elements to one another, there’s an influence on the adhesion or the power to stay them collectively. On this case, that’s significantly affected by the extent of curing that has occurred earlier than we tried to bond.”\nThe analysis advances the scientific understanding of how temperature can be utilized to control fabrication processes involving elastomers, which may open up the tender robotics design area for brand new or improved purposes. One key space of curiosity is the biomedical business.\n“Surgical robots usually profit from being compliant or tender in nature as a result of working contained in the human physique means you wish to decrease the danger of puncture or bruising to tissue or organs,” Preston stated.\n“So plenty of the robots that now function contained in the human physique are transferring to softer architectures and are benefiting from that. Some researchers have additionally began to look into utilizing tender robotic techniques to assist reposition sufferers confined to a mattress for lengthy durations of time to attempt to keep away from placing strain on sure areas.”\nDifferent areas of potential use for tender robotics are agriculture (as an example, selecting fruits or greens which can be fragile or bruise simply), catastrophe aid (search-and-rescue operations in impacted areas with restricted or tough entry), and analysis (accumulating or dealing with samples).\n“This research supplies a framework that might broaden the design area for manufacturing with thermally cured elastomers to create advanced buildings that exhibit excessive elasticity, which can be utilized to develop medical gadgets, shock absorbers, and tender robots,” Yap stated.\nSilicone elastomers’ distinctive properties—biocompatibility, flexibility, thermal resistance, shock absorption, insulation and extra—will proceed to be an asset in a spread of industries, and the present analysis might help broaden and enhance their use past present capabilities.\nTe Faye Yap et al, Thermally accelerated curing of platinum-catalyzed elastomers, Cell Stories Bodily Science (2024). DOI: 10.1016/j.xcrp.2024.101849\nAnalysis may advance tender robotics manufacturing and design (2024, March 18)\nretrieved 18 March 2024\nThis doc is topic to copyright. Other than any honest dealing for the aim of personal research or analysis, no\nhalf could also be reproduced with out the written permission. The content material is supplied for data functions solely.", "domain": "chemistry", "round": 3} +{"url": "http://cst-c.com.cn/products/53402.html", "date": "2017-02-22T03:56:04Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-09/segments/1487501170884.63/warc/CC-MAIN-20170219104610-00390-ip-10-171-10-108.ec2.internal.warc.gz", "language_score": 0.8168666362762451, "token_count": 1593, "dump": "CC-MAIN-2017-09", "global_id": "webtext-fineweb__CC-MAIN-2017-09__0__59944884", "lang": "en", "text": "Product Pathways - Tyrosine Kinase / Adaptors\nPathScan® Phospho-Tyro3 (panTyr) Sandwich ELISA Kit #53402\n|Product Includes||Volume||Solution Color|\n|ELISA Sample Diluent||25 ml|\n|Phospho Tyrosine Mouse Detection mAb||1 ea||Green (Lyophilized)|\n|Anti-mouse IgG, HRP-linked Antibody (ELISA Formulated)||1 ea||Red (Lyophilized)|\n|Detection Antibody Diluent||11 ml||Green|\n|HRP Diluent||11 ml||Red|\n|STOP Solution||11 ml||Colorless|\n|TMB Substrate #7004||11 ml||Colorless|\n|ELISA Wash Buffer (20X)||25 ml|\n|Cell Lysis Buffer (10X) #9803||15 ml|\n|Tyro3 Rabbit mAb Coated Microwells||1 ea|\n|Sealing Tape||2 sheets|\nSpecificity / Sensitivity\nPathScan® Phospho-Tyro3 (panTyr) Sandwich ELISA Kit recognizes endogenous levels of tyrosine-phosphorylated Tyro3 protein in human cells, as shown in Figure 1. The kit sensitivity is shown in Figure 2. This kit detects proteins from the indicated species, as determined through in-house testing, but may also detect homologous proteins from other species.\nPathScan® Phospho-Tyro3 (panTyr) Sandwich ELISA Kit is a solid phase sandwich enzyme-linked immunosorbent assay (ELISA) that detects endogenous levels of tyrosine-phosphorylated Mer protein. A Tyro3 Rabbit mAb has been coated onto the microwells. After incubation with cell lysates, Tyro3 protein (phospho and nonphospho) is captured by the coated antibody. Following extensive washing, a Phospho-Tyrosine Mouse Detection mAb is added to detect the captured phospho-Tyro3 proteins. Anti-mouse IgG, HRP-linked antibody is then used to recognize the bound detection antibody. HRP substrate, TMB, is added to develop color. The magnitude of optical density for this developed color is proportional to the quantity of Tyro3 protein phosphorylated on tyrosine residues.\nAntibodies in kit are custom formulations specific to kit.\nELISA - Western correlation\nFigure 1. Constitutive phosphorylation of Tyro3 in CHO/Tyro3 cells lysed in the presence of phosphatase inhibitors (phospho lysate) is detected by PathScan® Phospho-Tyro3 (panTyr) Sandwich ELISA Kit. In contrast, a low level of phospho-Tyro3 protein is detected in CHO/Tyro3 cells lysed in the absence of phosphatase inhibitors (nonphospho lysate). Similar levels of total Tyro3 protein from both nonphospho and phospho lysates are detected by PathScan® Total Tyro3 Sandwich ELISA Kit #39412 (upper, left). Absorbance at 450 nm is shown in the top figure while corresponding western blots using Tyro3(D38C6) Rabbit mAb #5585 (left) and a Phospho-Tyrosine Mouse mAb #9411 (right) are shown in the bottom figure. Phosphatase inhibitors include sodium pyrophosphate, β-glycerophosphate, and sodium orthovanadate.\nCHO/Tyro3 cells are derived from CHO cells tranfected with human Tyro3.\nFigure 2. The relationship between protein concentration of phospho or nonphospho lysates and the absorbance at 450 nm as detected by the PathScan® Phospho-Tyro3 (panTyr) Sandwich ELISA Kit is shown. Unstarved CHO cells were cultured (85% confluence) and transfected with human Tyro3 for 6 hrs, then lysed with or without addition of phosphatase inhibitors to the lysis buffer (phospho or nonphospho lysate, respectively).\nTyro3 is a receptor tyrosine kinase belonging to the TAM subfamily (Tyro3, Axl and Mer). All three members have similar domain structure composed of an extracellular region with 2 Ig-like domains, followed by 2 FNII-like domains, a single transmembrane region, and a cytoplasmic tyrosine kinase domain (1). The natural ligand for Tyro3, as well as Axl and Mer, is Gas6 (growth arrest-specific gene 6) (1,2). Expression pattern and target knockout data indicate an important role of Tyro3 in apoptotic cell phagocytosis of dendritic cells and macrophages (3), NK cell differentiation (4), reproductive neuron survival and migration (5), osteoclast stimulation (6,7), as well as cortical and hippocampal neuron function (8). Both MAPK and PI3K pathways have been suggested as downstream targets of Tyro3 activation (7,8). Tyro3 has also been shown to be correlated to melanoma tumorigenesis, likely through its reglulatory role in the expression of oncogenic microphthalmia-associated transcription factor (MITF) (9).\n- Binder, M.D. and Kilpatrick, T.J. (2009) Neurosignals 17, 277-87.\n- Nagata, K. et al. (1996) J Biol Chem 271, 30022-7.\n- Seitz, H.M. et al. (2007) J Immunol 178, 5635-42.\n- Caraux, A. et al. (2006) Nat Immunol 7, 747-54.\n- Pierce, A. et al. (2008) Mol Endocrinol 22, 2481-95.\n- Nakamura, Y.S. et al. (1998) Stem Cells 16, 229-38.\n- Katagiri, M. et al. (2001) J Biol Chem 276, 7376-82.\n- Prieto, A.L. et al. (2007) Neuroscience 150, 319-34.\n- Zhu, S. et al. (2009) Proc Natl Acad Sci U S A 106, 17025-30.\nHave you published research involving the use of our products? If so we'd love to hear about it. Please let us know!\n- 39412 PathScan® Total Tyro3 Sandwich ELISA Kit\n- 5585 Tyro3 (D38C6) Rabbit mAb\n- 7004 TMB Substrate\n- 7076 Anti-mouse IgG, HRP-linked Antibody\n- 9803 Cell Lysis Buffer (10X)\n- 9808 Phosphate Buffered Saline (PBS-20X)\n- 9809 Phosphate Buffered Saline with Tween® 20 (PBST-20X)\n- 9998 BSA\nFor Research Use Only. Not For Use In Diagnostic Procedures.\nCell Signaling Technology is a trademark of Cell Signaling Technology, Inc.\nPathScan is a trademark of Cell Signaling Technology, Inc.\nCell Signaling Technology® is a trademark of Cell Signaling Technology, Inc.\n用户评论 --- 共 0 条", "domain": "chemistry", "round": 3} +{"url": "https://agriculture.borax.com/regional-solutions/north-america/eastern-united-states-canada", "date": "2024-02-21T12:58:45Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707947473472.21/warc/CC-MAIN-20240221102433-20240221132433-00595.warc.gz", "language_score": 0.9547662734985352, "token_count": 342, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__158648861", "lang": "en", "text": "Requirements for boron vary substantially throughout the eastern United States depending on soil conditions and geography. Boron deficiency is more common in sandy soils of the southeast, which are low in organic matter content and more susceptible to leaching than the rich, fertile black soils of the northeast.\nCertain crops, such as peanuts and cotton, require much higher soil boron levels. Peanuts are typically grown in light, sandy, well-drained soils, which are inherently low in organic matter, including boron. Since boron is also readily leached from these soils, peanuts need a constant supply of boron during all stages of growth, especially from flowering to harvest. Cotton also demands boron in high amounts for proper flowering and boll development. This need is even greater in modern high-yielding varieties that fruit quickly. Because both peanuts and cotton are typically grown in in soils that lack the ability to hold boron, it can be difficult to build up and maintain levels in the soil. Annual application of boron is recommended.\nSoybeans, on the other hand, are tolerant of boron deficient soil. Even so, field studies show boron fertilization can increase soybean yields from 5 to 18 bushels per acre.\nGrowers in the southeast can optimize their crop production by knowing their crops’ nutrient requirements and how plants are impacted by other factors such as soil type and moisture level. If soil testing indicates a boron deficiency, farmers should follow their agronomist’s recommendations for the specific crop and area and request a refined, water soluble borate that supports plant health throughout the growing season.", "domain": "chemistry", "round": 3} +{"url": "https://ceramicartsnetwork.org/ceramic-recipes/recipe/Clay-Restoration", "date": "2023-12-02T17:40:48Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100448.65/warc/CC-MAIN-20231202172159-20231202202159-00529.warc.gz", "language_score": 0.9119688868522644, "token_count": 2416, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__145230826", "lang": "en", "text": "Many potters make a practice of reclaiming clay, but how do you restore the all of the properties that originally attracted you to the clay body?\nDefining the Terms\nBall Clay: A 2:1 aluminosilicate clay particle used to impart plasticity in a clay body.\nBentoneMA: Highly refined montmorillonite clay that imparts high plasticity and is used primarily in porcelain bodies.\nClay Body: A formulation of one or more types of clay, with feldspar and silica additions to produce specific firing properties at specific cone values.\nFeldspar: Natural alumino silicate minerals that supply sodium or potassium that act as a flux in a clay body.\nPlasticity: Mechanical property that allows a clay body to hold its shape after pressure from various forming techniques has been applied.\nPlasticizer: A clay mineral or synthetic additive that imparts malleability or flexibility to a clay body.\nSilica: Silicon dioxide (SiO2), also referred to as flint in older recipes, and as quartz in others. Primary milled from quartz, it is the primary glass former in most glaze and clay recipes.\nPotters refer to it as clay fatigue when describing the loss of plasticity. Every time you throw, fine particles of clay, silica, and feldspars are pulled from the clay body and deposited as slip on your hands. When clay is reclaimed after throwing, a percentage of plasticizer, silica, and feldspars are lost, pending the amount of water and pressure applied. In order to correct this loss, you must determine the level of plasticity your fresh clay had. Although it is not scientific, the first step is to conduct the “slip test.” Every potter is aware of the amount of slip that is deposited on their hands when they throw fresh clay. The amount of slip is an indication of the type and levels of plastic materials (clays) used in formulation. Use this simple guide:\n- Heavy slip buildup that passes between your fingers and requires constant removal indicates higher levels of plasticizers.\n- Medium slip buildup with some slip passing between your fingers requiring occasional removal indicates medium levels of plastic materials.\n- Light slip that requires occasional removal, but typically does not ooze, indicates lower levels of plasticizers. See sidebar for slip-test protocols.\nOf course every potter applies different levels of pressure and the amount of water they use differs. The trick then becomes to take the slip test after you center and are ready to start coning. Clean your hands before you start. Make four passes at coning, pulling up, and compressing, wetting one hand between each of the four passes. At the end of the fourth pass, assess the amount of slip deposited on your hands. Heavy, medium, or light slip? With this information, you now have an insight to how much plasticizer is in your favorite clay.\nIf your slip test produced heavy slip (1), then your clay has higher additions of fine particle ball clay. Medium slip (2) indicates either medium levels of plasticizer additions or a lower plasticity ball clay was used to make the clay body. Light slip (3) levels indicate lower levels of an added plasticizer. All throwing bodies require the addition of plasticizers in order to form properly on the wheel. These additions range from high plasticity ball clay such as Foundry Hill Creme (FCH) ball clay, to higher levels of medium plasticity ball clay such as OM 4. Premium white porcelains often use BentoneMA as the plasticizer in order to maintain higher levels of translucency.\nEach time you reclaim a batch of clay, the loss of fine particles of clays, plasticizer, silica, and feldspar increases until it begins affecting the original working properties. The loss of plasticizers affect`s malleability; while the loss of feldspar and silica will lower the vitrification levels and increase absorption. Using excessive water when throwing can accelerate the loss of fine particles as well. The easy fix is to keep the dry blend of your favorite clay on hand to add to your reclaim, if it is available. Most often it is not, so some simple clay chemistry is required to create a fix-it mix blend that will work with your clay body.\nMost stoneware bodies have some amount of ball clay in their composition. Mix 80% OM 4 ball clay, 10% silica, and 10% nepheline syenite or 10% G200 feldspar until it is well blended. Add 1 cup of dry mix per gallon of slurry if you had heavy slip, ½ cup for medium, and ¼ cup for light slip results from your original slip test. This one-size-fits-all blend will help maintain plasticity and ensure absorption rates do not increase due to silica and feldspar loss. Check your reclaim as you go along and adjust additions to suit your taste. Before you begin to test for plasticity, remember it will take several days before full plasticity develops. You can check it by doing a simple coil test: roll the clay to a ¼-inch-thick coil and wrap it around your middle finger. If no stress cracks develop, then it is ready for use. However, if it acts rubbery, then reduce your fix-it mix additions by 1⁄ 3.\nMaking a dry blend of fix-it mix to add to porcelain requires a bit more chemistry, starting with analyzing the color of the clay. White or off-white color indicates that premium plasticizers or a whitish ball clay such as C&C have been used for plasticity. Does your porcelain body produce translucent properties after glaze firing, or does it fire to a bright white finish? Premium white porcelains use BentoneMA as the plasticizer. Most white porcelains typically create the same slip buildup because BentoneMA is the primary plasticizer. Ball clay additions would minimize translucency due to titanium content. After answering these questions, you need to decide how much of the necessary ingredients to buy, which is directly related to how much you reclaim. Most suppliers sell BentoneMA in ¼-pound, 1-pound, and 5-pound bags. This material is pricey, but the good news is that a little goes a long way. Most porcelain bodies use nepheline syenite as a body flux, so limit the feldspar replacement in your mix to nepheline syenite.\nTest Protocols for Clay Restoration\nStart with 1000 grams (dry weight) of 80% clay(s), 10% silica, and 10% potash feldspar—a typical stoneware formula—and mix with water to a usable consistency. Cone the clay on the wheel with heavy pressure and water. Dry and weigh the collected slip, with an added 10% approximation for slip lost in the water. For porcelain, two 1000-gram recipes were used: Porcelain A (50% Grolleg, 20% silica, 30% potash, and 2.5% BentoneMA) and Porcelain B (35% Grolleg, 15% Foundry Hill Creme ball clay, 20% silica, and 30% potash feldspar (cone 6)).\nIf your clay is bright white and/or translucent, dry blend a fix-it mix of 50% Grolleg kaolin, 25% nepheline syenite, and 25% silica together and set aside. Add 2% BentoneMA to this white porcelain dry mix and thoroughly blend. Add ½ cup of dry mix per gallon of slurry or ¼ cup if you prefer slightly less plasticity. Spend extra time blending this slurry addition to ensure even distribution of this specialty plasticizer.\nIf your fresh porcelain clay body is off white, gray, tan, or fires off white, it probably includes ball clay. Porcelain tile bodies incorporate larger particle-sized kaolin such as #6 Tile clay, and have a light tan color. Most often ball clays are used as plasticizers in order to keep their price points lower. Other porcelain bodies may be light gray in color, which is the result of another type of ball clay. White porcelain follows the pure standard of 50% kaolin, 25% silica, and 25% feldspar. Bodies that use ball clay as the plasticizer follow a standard of 35% kaolin, 15% ball clay, 25% silica, and 25% feldspar, and are less white, with no translucency. Some recipes follow a standard of 25% kaolin and 25% ball clay, 25% silica, and 25% feldspar, which is known as 50/50 porcelain.\nWith porcelain clay bodies made with ball clay, the slip test becomes relevant to determine the ratio of ingredients when mixing a dry maintenance blend. Heavy slip indicates the porcelain is closer to equal parts of kaolin and ball clay. Medium slip indicates a mixture toward the 35% kaolin and 15% ball clay range. In this case, leave light slip buildup off the list because of the numerous variables involved. You must also make a decision of how precisely you want to duplicate the original blend. Gray-body porcelains may incorporate FHC or an equal ball clay, which has a higher plasticity index than OM 4. FHC is medium gray in color. Tan colored porcelains use OM 4 or equivalent types of ball clay for plasticity, which give the porcelain body its color.\nThe fix-it mix for ball-clay porcelains that produce heavy slip buildup is 25% EPK kaolin, 25% OM 4 ball clay, 25% silica, and 25% nepheline syenite. For medium slip buildup the fix-it mix is: 35% EPK, 15% OM 4, 25% silica, and 25% nepheline syenite. Add 1 cup per gallon of slurry. If the body color is gray or if you prefer high plasticity, swap out the 15% OM 4 ball clay for FHC. Add ½ cup of dry mix per 1 gallon of slurry.\nIf you are certain bentonite has been used as a plasticizer, then only add up to 1⁄8 cup per 1 gallon of slurry. Bentonite should be dispersed slowly in a cup of warm water first, then add this solution slowly to your clay slurry, mixing as you add it.\nPut It to the Test\nThese are one-size-fits-all remedial fixes that do not require exact clay chemistry and incorporate pocket-book friendly ingredients. Once you throw the reclaimed clay using these fixes, make a determination if the plasticity level is too high or too low for your personal use. The true test is to compare your reclaim to the original clay body, putting both to the coil test as mentioned above. You should also perform an absorption test if you are making functional ware. If absorption has risen above 2%: increase the fix-it mix by 10% over the initial addition to help lower absorption back into range. If you own a pugmill, estimate how many gallons of slurry the chamber holds and multiply the fix-it mix accordingly.\nthe author Thomas Anderson has spent the last decade researching technical papers from various universities on clay formulation. He is currently writing formula limits for clay chemistry.\nExcerpted from the June/July/August 2019 issue of Ceramics Monthly.", "domain": "chemistry", "round": 3} +{"url": "https://core-cms.prod.aop.cambridge.org/core/search?filters%5BauthorTerms%5D=M.%20C.%20%C3%96zt%C3%BCrk&eventCode=SE-AU", "date": "2021-06-20T08:06:10Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-25/segments/1623487658814.62/warc/CC-MAIN-20210620054240-20210620084240-00000.warc.gz", "language_score": 0.9552702307701111, "token_count": 317, "dump": "CC-MAIN-2021-25", "global_id": "webtext-fineweb__CC-MAIN-2021-25__0__157526488", "lang": "en", "text": "We have found the dissociation behavior of immiscible Cu-alloy thin films to fall into three broad categories that correlate most closely with the form of the Cu-rich end of the binary alloy phase diagrams. The motivation for these studies was to use the energy released by the dissociation of an immiscible alloy, in addition to other driving forces commonly found in thin films and lines, to promote grain growth and texture evolution. In this work, the dissociation behavior of eight dilute (3.3 ± 0.5 at% solute) binary Cu-systems was investigated, with five alloying elements selected from group VB and VIB, two from group VillA, and one from group 1B. These alloying elements are respectively V, Nb, Ta, Cr, Mo, Fe, Ru and Ag. Several experimental techniques, including in situ resistance and stress measurements as well as in situ synchrotron x-ray diffraction, were used to follow the progress of solute precipitation in approximately 500 nm thick films. In addition, transmission electron microscopy was used to investigate the evolution of microstructure of Cu(Ta) and Cu(Ag). For all eight alloys, dissociation occurred upon heating, with the rejection of solute and evolution of microstructure and texture often occurring in multiple steps that range over several hundred degrees between approximately 100 and 900°C. However, in most cases, substantial reduction in resistivity of the films took place at temperatures of interest to metallization schemes, namely below 400°C.", "domain": "chemistry", "round": 3} +{"url": "http://www.travelholidayhotel.com/Article/20180710/Can-Automatic-Trans-Fluid-Be-Used-as-Diesel-Fuel.html", "date": "2019-02-16T11:30:14Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-09/segments/1550247480272.15/warc/CC-MAIN-20190216105514-20190216131514-00209.warc.gz", "language_score": 0.9672028422355652, "token_count": 271, "dump": "CC-MAIN-2019-09", "global_id": "webtext-fineweb__CC-MAIN-2019-09__0__74427457", "lang": "en", "text": "Fuel AdditiveMost people that use automatic transmission fluid (ATF) in a diesel engine use it as a fuel additive rather than as a standalone fuel. The intended purpose of the addition is to use the ATF's lubricating and cleaning properties to clean out the engine and improve overall performance. Tests have indicated, however, that adding ATF does not provide any discernible benefit.\nAlternative FuelMany diesel engines, particularly older ones with looser fuel tolerances, are capable of burning and running on pure ATF in place of diesel fuel, and a small number of people collect and filter used ATF for this purpose.\nPotential ProblemsNewer, computer-controlled engines may have difficulty with any fuel that has significantly different physical properties from standard diesel fuel. ATF does not burn as readily as diesel, and it is much more viscous. While the engine may run on ATF for a time, doing so over the long term may cause significant damage to the fuel system. And because ATF is not a government-approved fuel, it could lead to legal consequences for the user. Diesel engines are well known for being able to run on a very wide variety of fuels. This has led some people to speculate on the possibility of running a diesel engine on oils, such as automatic transmission fluid, that were never meant to be fuels but are often readily available for free.", "domain": "chemistry", "round": 3} +{"url": "https://www.semanticscholar.org/author/John-W-McClory/3179465", "date": "2017-05-27T10:56:17Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-22/segments/1495463608936.94/warc/CC-MAIN-20170527094439-20170527114439-00263.warc.gz", "language_score": 0.7676287293434143, "token_count": 321, "dump": "CC-MAIN-2017-22", "global_id": "webtext-fineweb__CC-MAIN-2017-22__0__193054466", "lang": "en", "text": "- Full text PDF available (4)\nWe review the pyroelectric properties and electronic structure of Li 2 B 4 O 7 (110) and Li 2 B 4 O 7 (100) surfaces. There is evidence for a pyroelectric current along the direction of stoichiometric Li 2 B 4 O 7 so that the pyroelectric coefficient is nonzero but roughly 10 3 smaller than along the direction of spontaneous polarization. Abrupt… (More)\n\"The chromium site in doped glassy lithium tetraborate\" (2014). Peter Dowben Publications. Paper 261. h i g h l i g h t s g r a p h i c a l a b s t r a c t Adoption of the Li þ site for chromium dopants in lithium tetraborate identified. Increased oxygen coordination for glass over the crystalline lithium tetraborate. Distortions about the doping chromium… (More)\nReversible Mn segregation at the polar surface of lithium tetraborate\" (2013). Peter Dowben Publications. Paper 256.\nThe four dopants (Nd, Gd, Dy, and Er) substitutionally occupy the Li + sites in lithium tetraborate (Li 2 B 4 O 7 : RE) glasses as determined by analysis of the extended X-ray absorption fine structure. The dopants are coordinated by 6-8 oxygen at a distance of 2.3 to 2.5 Å, depending on the rare earth. The inverse relationship between the RE-O coordination… (More)", "domain": "chemistry", "round": 3} +{"url": "https://www.uaex.uada.edu/media-resources/news/2017/april2017/04-28-2017-Ark-alfalfa-nutrient-management.aspx", "date": "2022-06-26T14:34:59Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-27/segments/1656103269583.13/warc/CC-MAIN-20220626131545-20220626161545-00396.warc.gz", "language_score": 0.8863312005996704, "token_count": 750, "dump": "CC-MAIN-2022-27", "global_id": "webtext-fineweb__CC-MAIN-2022-27__0__125763927", "lang": "en", "text": "Alfalfa requires careful nutrient management for maximum benefit\nBy Fred Miller\nU of A System Division of Agriculture\nApril 28, 2017\n- Alfalfa forages require careful nutrient management, especially in spring.\n- Because of high nutrient removal rate, alfalfa is sensitive to nutrient deficiencies.\n- Crucial nutrient requirements include phosphorus, potassium and calcium.\n(Download a MS Word version of this story here.)\nFAYETTEVILLE, Ark. — Alfalfa makes a quality forage or hay crop, but its growth habits require careful nutrient management, said Dirk Philipp, forage researcher for the University of Arkansas System Division of Agriculture.\nAlfalfa removes nutrients from the soil at a high rate and is sensitive to nutrient deficiencies, Philipp said. “It will quickly reduce yields and persistence if soil fertility is not kept at optimum levels,” he said.\nThe issue is not nitrogen, Philipp said. Alfalfa is a legume that fixes the nitrogen it needs through a symbiotic relationship with bacteria in the soil.\nThe key nutrients that require management are phosphorus, potassium and calcium, Philipp said. Inadequate phosphorus and potassium, in particular, can lead to plant deficiencies that will be costly to correct.\nPhilipp emphasizes the importance of keeping current on soil tests. “Make a habit out of testing soil every one to two years,” he said. The Division of Agriculture offers free soil tests.\n“Springtime is crucial for keeping up with soil fertility demands in crops like alfalfa,” Philipp said. “Growth rates are high in spring and soil fertility is usually a low priority during winter.”\n- Removal rates should be calculated when the forage or hay is removed. A ton of alfalfa dry matter removes about 50 pounds of actual potassium and about 6 pounds of actual phosphorus. A ton of dry alfalfa also removes about 30 pounds of calcium.\n- Apply phosphorus and potassium immediately after the first cut. Split the application if the amount needed is really large.”\n- Be smart in purchasing fertilizer; calculate the actual cost of the mineral per unit of fertilizer.\n- Minimize passes across the field by purchasing fertilizer that replaces as many of the needed minerals as possible.\nSoil pH are also critical, Philipp said. Nutrients are most available to alfalfa when soil pH is between 5.5 and 7.5, he said. The availability of soil nutrients may be greatly reduced when pH is above or below that range.\nIf soil tests call for lime, make applications in the fall because it takes six to eight months to change soil pH, Philipp said. If pH is very low, lime application can be made in the spring.\n“And keep up with soil test reports,” Philipp said. “This cannot be said enough.”\nFree Division of Agriculture soil tests can be arranged by contacting the local County Extension Office.\nThe University of Arkansas System Division of Agriculture offers all its Extension and Research programs to all eligible persons without regard to race, color, sex, gender identity, sexual orientation, national origin, religion, age, disability, marital or veteran status, genetic information, or any other legally protected status, and is an Affirmative Action/Equal Opportunity Employer.\n# # #\nMedia Contact: Mary Hightower\nDir. of Communication Services\nU of A Division of Agriculture\nCooperative Extension Service", "domain": "chemistry", "round": 3} +{"url": "https://pubmed.ncbi.nlm.nih.gov/9723621/?dopt=Abstract", "date": "2021-07-30T16:52:13Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-31/segments/1627046153971.20/warc/CC-MAIN-20210730154005-20210730184005-00174.warc.gz", "language_score": 0.9222584366798401, "token_count": 295, "dump": "CC-MAIN-2021-31", "global_id": "webtext-fineweb__CC-MAIN-2021-31__0__100687812", "lang": "en", "text": "Lateral heterogeneities in the classical fluid-mosaic model of cell membranes are now envisaged as domains or 'rafts' that are enriched in (glyco)sphingolipids, cholesterol, specific membrane proteins and glycosylphosphatidylinositol (GPI)-anchored proteins. These rafts dictate the sorting of associated proteins and/or provide sites for assembling cytoplasmic signalling molecules. However, there is no direct evidence that rafts exist in living cells. We have now measured the extent of energy transfer between isoforms of the folate receptor bound to a fluorescent analogue of folic acid, in terms of the dependence of fluorescence polarization on fluorophore densities in membranes. We find that the extent of energy transfer for the GPI-anchored folate-receptor isoform is density-independent, which is characteristic of organization in sub-pixel-sized domains at the surface of living cells; however, the extent of energy transfer for the transmembrane-anchored folate-receptor isoform was density-dependent, which is consistent with a random distribution. These domains are likely to be less than 70 nm in diameter and are disrupted by removal of cellular cholesterol. These results indicate that lipid-linked proteins are organized in cholesterol-dependent submicron-sized domains. Our methodology offers a new way of monitoring nanometre-scale association between molecules in living cells.", "domain": "chemistry", "round": 3} +{"url": "https://www.rcsb.org/structure/2jfm", "date": "2023-12-04T16:21:25Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100531.77/warc/CC-MAIN-20231204151108-20231204181108-00089.warc.gz", "language_score": 0.7879757881164551, "token_count": 399, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__140000740", "lang": "en", "text": "Activation Segment Dimerization: A Mechanism for Kinase Autophosphorylation of Non-Consensus Sites.Pike, A.C.W., Rellos, P., Niesen, F.H., Turnbull, A., Oliver, A.W., Parker, S.A., Turk, B.E., Pearl, L.H., Knapp, S.\n(2008) EMBO J 27: 704\n- PubMed: 18239682\n- DOI: https://doi.org/10.1038/emboj.2008.8\n- Primary Citation of Related Structures:\n2J51, 2J7T, 2J90, 2JFL, 2JFM, 2UV2\n- PubMed Abstract:\nProtein kinase autophosphorylation of activation segment residues is a common regulatory mechanism in phosphorylation-dependent signalling cascades. However, the molecular mechanisms that guarantee specific and efficient phosphorylation of these sites have not been elucidated. Here, we report on three novel and diverse protein kinase structures that reveal an exchanged activation segment conformation. This dimeric arrangement results in an active kinase conformation in trans, with activation segment phosphorylation sites in close proximity to the active site of the interacting protomer. Analytical ultracentrifugation and chemical cross-linking confirmed the presence of dimers in solution. Consensus substrate sequences for each kinase showed that the identified activation segment autophosphorylation sites are non-consensus substrate sites. Based on the presented structural and functional data, a model for specific activation segment phosphorylation at non-consensus substrate sites is proposed that is likely to be common to other kinases from diverse subfamilies.\nStructural Genomics Consortium, Botnar Research Centre, University of Oxford, Oxford, UK.", "domain": "chemistry", "round": 3} +{"url": "https://www.omicsonline.org/references/aggresome-induction-by-proteasome-inhibitor-bortezomib-and-alphatubulin-hyperacetylation-by-tubulin-deacetylase-tdac-inhibitor-lbh589-are-synergistic-in-myeloma-62534.html", "date": "2017-08-19T14:28:18Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-34/segments/1502886105451.99/warc/CC-MAIN-20170819124333-20170819144333-00569.warc.gz", "language_score": 0.9112396240234375, "token_count": 303, "dump": "CC-MAIN-2017-34", "global_id": "webtext-fineweb__CC-MAIN-2017-34__0__54128986", "lang": "en", "text": "Author(s): Catley L, Weisberg E, Kiziltepe T, Tai YT, Hideshima T,\nAbstract Share this page\nAbstract Histone deacetylase (HDAC) inhibitors have shown cytotoxicity as single agents in preclinical studies for multiple myeloma (MM) cells. LBH589 is a novel hydroxamic acid derivative that at low nanomolar concentrations induces apoptosis in MM cells resistant to conventional therapies via caspase activation and poly-(ADP-ribose) polymerase (PARP) cleavage. Significant synergistic cytotoxicity was observed with LBH589 in combination with bortezomib against MM cells that were sensitive and resistant to dexamethasone (Dex), as well as primary patient MM cells. LBH589 at low nanomolar concentrations also induced alpha-tubulin hyperacetylation. Aggresome formation was observed in the presence of bortezomib, and the combination of LBH589 plus bortezomib induced the formation of abnormal bundles of hyeracetylated alpha-tubulin but with diminished aggresome size and apoptotic nuclei. These data confirm the potential clinical benefit of combining HDAC inhibitors with proteasome inhibitors, and provide insight into the mechanisms of synergistic anti-MM activity of bortezomib in combination with LBH589.\nThis article was published in Blood\nand referenced in Translational Medicine", "domain": "chemistry", "round": 3} +{"url": "https://experts.umn.edu/en/publications/cost-of-a-naturally-occurring-two-amino-acid-deletion-in-cytochro", "date": "2023-03-29T14:14:17Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-14/segments/1679296948976.45/warc/CC-MAIN-20230329120545-20230329150545-00266.warc.gz", "language_score": 0.8977575302124023, "token_count": 380, "dump": "CC-MAIN-2023-14", "global_id": "webtext-fineweb__CC-MAIN-2023-14__0__225580408", "lang": "en", "text": "This study aimed to determine whether a naturally occurring (δTrp85, δVal86) deletion from a protein subunit of cytochrome c oxidase (complex IV) influenced cytochrome c oxidase activity, mRNA expression levels of electron transport chain genes, and aspects of adult female fitness in the fly Drosophila simulans.We modeled the tertiary structure of D. simulans cox7A containing the deletion by homology to the bovine cox7A structure and predicted that it would decrease the function of complex IV. This prediction led to the hypothesis that flies with the deletion would have lower cytochrome c oxidase activity and higher levels of mRNA expression from cox7A. This result was observed, but unexpectedly, elevated levels of mRNA expression were also observed in genes encoding subunits of complexes I, III, and IV. Together these data suggest that the deletion causes a high bioenergetic cost to the organism. To investigate the predicted cost at a physiological level, we assayed aspects of adult female fitness. Starvation sensitivity but not feeding rate was significantly influenced by the two-amino acid deletion. Further, we observed that carbohydrate and protein levels but not lipid levels were higher in the mutant flies. Together, these data show that quaternary structure modeling and biochemistry can be used to link the genotype with the organismal phenotype.\n|Original language||English (US)|\n|State||Published - Oct 1 2010|\n- Complex IV\n- Oxidative phosphorylation\n- mRNA expression", "domain": "chemistry", "round": 3} +{"url": "https://iovs.arvojournals.org/article.aspx?articleid=2160232", "date": "2018-09-21T18:39:00Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-39/segments/1537267157351.3/warc/CC-MAIN-20180921170920-20180921191320-00455.warc.gz", "language_score": 0.8509030342102051, "token_count": 267, "dump": "CC-MAIN-2018-39", "global_id": "webtext-fineweb__CC-MAIN-2018-39__0__194983398", "lang": "en", "text": "Purchase this article with an account.\nL Lorand, S M Conrad, P T Velasco; Inhibition of beta-crystallin cross-linking in the Ca2+-treated lens.. Invest. Ophthalmol. Vis. Sci. 1987;28(7):1218-1222.\nDownload citation file:\n© ARVO (1962-2015); The Authors (2016-present)\nbeta-Crystallin dimers of approximately 55,000 weight are among the early products of protein cross-linking in Ca2+-treated rabbit lens, caused by the activation of intrinsic transglutaminase; formation of the cross-linked species can be blocked by 75 mM histamine (Lorand et al, Biochemistry, 24:1525-1531, 1985). As an extension of this work, we initiated a search for more specific inhibitors of cross-linking in this system. Of the compounds tested so far, hydroxylamine, methoxyamine, bisaminoxypropane and aminoacetonitrile were particularly effective, inhibiting the generation of the cross-linked dimer in the 5 to 10 mM concentration range during a 4 hr treatment of the lens with Ca2+-ions.\nThis PDF is available to Subscribers Only", "domain": "chemistry", "round": 3} +{"url": "https://amst.utm.my/index.php/amst/article/view/126", "date": "2023-12-10T17:14:25Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679102612.80/warc/CC-MAIN-20231210155147-20231210185147-00069.warc.gz", "language_score": 0.6842947006225586, "token_count": 2574, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__220602476", "lang": "en", "text": "Factors Affecting Membrane Distillation Process for Seawater Desalination\nMembrane distillation (MD), a process based on the thermal principle, is a combination of distillation and membrane separation in the same unit. There are many factors that can affect the MD performance, but the membrane characteristics are the most important in this process. The changes in the membrane properties affect the process efficiency, the permeate flux as well as the membrane lifetime. Some of the membrane properties mentioned in this paper include liquid entry pressure (LEP), contact angle, pore size, porosity, thickness, thermal conductivity, support layer, tortuosity, etc. This review paper aims to evaluate the membrane properties in order to reduce membrane wetting and to improve desalination efficiency. From this review, it can be seen that the LEP and contact angle are the important factors which directly affect the hydrophobicity of the membrane. When LEP and the contact angle increase, the hydrophobicity of the membrane increases. Thus, the membrane is durable and the MD system works efficiently. The remaining factors indirectly affect the operation of the MD system through LEP and contact angle (hydrophobicity).\nM. M. Mekonnen, A. Y. Hoekstra. 2016. Four Billion People Facing Severe Water Scarcity. Sci. Adv. 2: 1-6.\nJ. Deshpande, K. Nithyanandam, R. Pitchumani. 2017. Analysis and Design of Direct Contact Membrane Distillation. J. Membr. Sci. 523: 301-316.\nM. R. Qtaishat, F. Banat. 2013. Desalination by Solar-powered Membrane Distillation Systems. Desalination. 308: 186-197.\nA. F. Ismail, K. C. Khulbe, T. Matsuura. 2017. Recent Progress in Reverse Osmosis (RO) Science and Technology. J. Applied Membrane Science & Technology. 21: 1-10.\nJ. Morillo, J. Usero, D. Rosado, H. E. Bakouri, A. Riaza, F. J. Bernaola. 2014. Comparative Study of Brine Management Technologies for Desalination Plants. Desalination. 336: 32-49.\nA. Laorko, S. Tongchitpakdee, W. Youravong. 2015. Economic Assessment for Cold Sterilization and Clarification of Pineapple Juice and Coconut Water Using Microfiltration. J. Applied Membrane Science & Technology. 17: 35-46.\nA. M. Elzahaby, A. E. Kabeel, M. M. Bassuoni, A. R. A. Elbar. 2016. Direct Contact Membrane Water Distillation Assisted with Solar Energy. Energy Conversion and Management. 110: 397-406.\nL. M. Camacho, L. Dumée, J. Zhang, J. Li, M. Duke, J. Gomez, S. Gray. 2013. Advances in Membrane Distillation for Water Desalination and Purification Applications: A Review. Water. 5: 94-196.\nA. M. Alklaibi, N. Lior. 2005. Membrane-distillation Desalination: Status and Potential. Desalination. 171: 111-131.\nW. T. Hanbury, T. Hodgkiess. 1985. Membrane Distillation—An Assessment. Desalination. 56: 287-297.\nA. Alkhudhiri, N. Darwish, N. Hilal. 2012. Membrane Distillation: A Comprehensive Review. Desalination. 287: 2-18.\nA. Subramani and J. G. Jacangelo. 2015. Review: Emerging Desalination Technologies for Water Treatment: A Critical Review. Water Research. 75: 164-187.\nL. D. Tijing, Y. C. Woo, J. S. Choi, S. Lee, S. H. Kim, H. K. Shon. 2015. Fouling and Its Control in Membrane Distillation—A Review. J. Membr. Sci. 475: 215-244.\nD. M. Warsinger, J. Swaminathan, E. Guillen-Burrieza, H. A. Arafat, J. H. Lienhard. 2015. Scaling and Fouling in Membrane Distillation for Desalination Applications: A Review. Desalination. 356: 294-313.\nE. Drioli, A. Ali, F. Macedonio. 2015. Membrane Distillation: Recent Developments and Perspectives. Desalination. 356: 56-84.\nB. B. Ashoor, S. Mansour, A. Giwa, V. Dufour, S. W. Hasan. 2016. Principles and Applications of Direct Contact Membrane Distillation (DCMD): A Comprehensive Review. Desalination. 398: 222-246.\nM. Khayet. 2011. Membranes and Theoretical Modeling of Membrane Distillation: A Review. Adv. Colloid Interface Sci. 164: 56-88.\nL. Eykens, K. De Sitter, C. Dotremont, L. Pinoy, B. Van der Bruggen. 2017. Membrane Synthesis for Membrane Distillation: A Review. Sep. Purif. Technol. 182: 36-51.\nM. E. Findley. 1967. Vaporization through Porous Membranes. Ind. Eng. Chem. Proc. Des. Dev. 6: 226-230.\nL. Eykens, I. Hitsov, K. De Sitter, C. Dotremont, L. Pinoy, I. Nopens, B. Van der Bruggen. 2016. Influence of Membrane Thickness and Process Conditions on Direct Contact Membrane Distillation at Different Salinities. J. Membr. Sci. 498: 353-364.\nJ. Li, Y. Guan, F. Cheng, Y. Liu. 2015. Treatment of High Salinity Brines by Direct Contact Membrane Distillation: Effect of Membrane Characteristics and Salinity. Chemosphere. 140: 143-149.\nT. Zhou, Y. Yao, R. Xiang, Y. Wu. 2014. Formation and Characterization of Polytetrafluoroethylene Nanofiber Membranes for Vacuum Membrane Distillation. J. Membr. Sci. 453: 402-408.\nK. W. Lawson, D. R. Lloyd. 1997. Membrane Distillation. J. Membr. Sci. 124: 1-25.\nC. Gostoli, G.C. Sarti. 1989. Separation of Liquid Mixtures by Membrane Distillation. J. Membr. Sci. 41: 211-224.\nJ. Ge, Y. Peng, Z. Li, P. Chen, S. Wang. 2014. Membrane Fouling and Wetting in a DCMD Process for RO Brine Concentration. Desalination. 344: 97-107.\nY. Yuan, T. R. Lee. 2013. Contact Angle and Wetting Properties. Surf. Sci. Tech. 51: 3-34.\nA. K. Fard, Y. Manawi. 2014. Seawater Desalination for Production of Highly Pure Water Using a Hydrophobic PTFE Membrane and Direct Contact Membrane Distillation (DCMD). WASET. 8: 391-399.\nS. N. W. Ikhsan, N. Abdullah, N. Yusof, F. Aziz, N. Misdan, N. H. H. Hairom. 2017. Polyethersulfone/HFO Mixed Matrix Membrane for Enhanced Oily Wastewater Rejection. J. Applied Membrane Science & Technology. 20: 11-17.\nH. Zhu, H. Wang, F. Wang, Y. Guo, H. Zhang, J. Chen. 2013. Preparation and Properties of PTFE Hollow Fiber Membranes for Desalination Through Vacuum Membrane Distillation. J. Membr. Sci. 446: 145-153.\nY. Z. Tan, J. W. Chew, W. B. Krantz. 2016. Effect of Humic-acid Fouling on Membrane Distillation. J. Membr. Sci. 504: 263-273.\nX. Yu, H. Yang, H. Lei, A. Shapiro. 2013. Experimental Evaluation on Concentrating Cooling Tower Blowdown Water by Direct Contact Membrane Distillation. Desalination. 323: 134-141.\nM. M. A. Shirazia, A. Kargari, M. Tabatabaei. 2014. Evaluation of Commercial PTFE Membranes in Desalination by Direct Contact Membrane Distillation. Chem. Eng. Process. 76: 16-25.\nA. Khalifa, H. Ahmada, M. Antar, T Laoui, M. Khayet. 2017. Experimental and Theoretical Investigations on Water Desalination Using Direct Contact Membrane Distillation. Desalination. 404: 22-34.\nR. Naim, S. Abdullah. 2015. Membrane Wetting in Membrane Contactor System: A Review. J. Applied Membrane Science & Technology. 17: 9-15.\nS. Adnan, M. Hoang, H. Wang, Z. Xie. 2012. Commercial PTFE Membranes for Membrane Distillation Application: Effect of Microstructure and Support Material. Desalination. 284: 297-308.\nA. Ali, C.A. Quist-Jensen, F. Macedonio, E. Drioli. 2016. On Designing of Membrane Thickness and Thermal Conductivity for Large-Scale Membrane Distillation Modules. JMSR. 2: 179-185.\nK. He, H. J. Hwang, M. W. Woo, I. S. Moon. 2017. Production of Drinking Water from Saline Water by Direct Contact Membrane Distillation (DCMD). Journal of Industrial and Engineering Chemistry. 17: 41-48.\nZ. Lia, Y. Peng, Y. Dong, H. Fan, P. Chen, L. Qiu, Q. Jiang. 2014. Effects of Thermal Efficiency in DCMD and the Preparation of Membranes with Low Thermal Conductivity. Appl. Surf. Sci. 317: 338-349.\nA. Luo, N. Lior. 2017. Study of Advancement to Higher Temperature Membrane Distillation. Desalination. 419: 88-100.\nM. Khayet, T. Matsuura, J.I. Mengual, M. Qtaishat. 2006. Design of Novel Direct Contact Membrane Distillation Membranes. Desalination. 192: 105-111.\nP. Wang, T. S. Chung. 2015. Recent Advances in Membrane Distillation Processes: Membrane Development, Configuration Design and Application Exploring. J. Membr. Sci. 474: 39-56.\nS. B. Iversen, V. K. Bhatia, K. Dam-Johansen, G. Jonsson. 1997. Characterization of Microporous Membranes for Use in Membrane Contactors. J. Membr. Sci. 130: 205-217.\nHow to Cite\nCopyright of articles that appear in Journal of Applied Membrane Science & Technology belongs exclusively to Penerbit Universiti Teknologi Malaysia (Penerbit UTM Press). This copyright covers the rights to reproduce the article, including reprints, electronic reproductions, or any other reproductions of similar nature.", "domain": "chemistry", "round": 3} +{"url": "http://haenerblock.com/faq/often-asked-how-to-remove-stains-from-concrete-floor.html", "date": "2024-03-03T21:33:22Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707947476399.55/warc/CC-MAIN-20240303210414-20240304000414-00829.warc.gz", "language_score": 0.880372941493988, "token_count": 1221, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__83492039", "lang": "en", "text": "- 1 What is the best concrete stain remover?\n- 2 Will vinegar remove stains from concrete?\n- 3 How do you clean badly stained concrete?\n- 4 Can you use bleach to clean concrete?\n- 5 Will baking soda damage concrete?\n- 6 Does WD 40 remove oil stains from concrete?\n- 7 Does vinegar harm concrete?\n- 8 How do you remove black stains from concrete?\n- 9 Can Simple Green Clean concrete?\n- 10 Does Coca Cola remove oil stains from concrete?\n- 11 Will straight bleach harm concrete?\n- 12 How do you deep clean concrete floors?\n- 13 What is the best way to clean a concrete garage floor?\n- 14 How can I make my concrete white again?\n- 15 What can you clean concrete floors with?\nWhat is the best concrete stain remover?\nBest Concrete Oil Stain Remover\n- Terminator Concrete Stain & Grease Remover.\n- EXIMO Waterless Concrete Cleaner.\n- PROSOCO Oil & Grease Stain Remover for Driveways.\n- Krud Cutter Concrete & Driveway Pressure Washer Concentrate – Best degreaser for oil on concrete.\nWill vinegar remove stains from concrete?\nYes. Vinegar makes a great cleaner for stained concrete floors. Because of its acidity, you should dilute it 50/50 with warm water to avoid damaging the floors. However, you can use small amounts of full-strength vinegar for touch stains, followed by a quick water rinse.\nHow do you clean badly stained concrete?\nMix 1/2 cup baking soda to one gallon of water for a gentle cleaning solution. Add 1/8 cup of liquid dish detergent. Spray on patio surface, let sit for 30 minutes, then scrub and rinse. For heavily stained or mildewed patios, you may need a pressure washer.\nCan you use bleach to clean concrete?\nFor lightly soiled concrete, you can remove dirt by using bleach mixed with water. Add 1/8th cup of liquid dishwashing detergent to the solution and pour it into a spray bottle. Spray the solution onto the surface, and let it sit for a few minutes. Scrub with a nylon-bristled brush.\nWill baking soda damage concrete?\nWhen washing concrete, be wary of using any strong chemicals, particularly any acid-based cleaners—these can damage concrete. Instead, use gentle washing agents such as baking soda, dish soap, and water. There are several methods you can try to get your concrete looking like new again.\nDoes WD 40 remove oil stains from concrete?\nWD–40 is an effective grease stain remover. In some cases, WD–40 can remove oil stains from concrete. However, it isn’t as effective as other methods and depends on how old the stain is. If you have it on hand, you can give it a try by spraying it on the stain and letting it sit for 30 minutes.\nDoes vinegar harm concrete?\nVinegar does not dissolve concrete itself but can degrade the cement that binds concrete together. As a weak, dilute acid, vinegar will cause only minor damage to concrete but can take the shine off polished surfaces. It can, however, be used to remove small amounts of cement from tools.\nHow do you remove black stains from concrete?\nMeanwhile- for black spots caused by poor workmanship during concrete patio/surface installation, you can eliminate them by spraying warm water on the concrete surface and scrubbing repeatedly until the spots disappear. Alternatively, you can acid wash the surface.\nCan Simple Green Clean concrete?\nYou can use Simple Green Oxy Solve Concrete and Driveway Cleaner to clean a concrete patio with or without a pressure washer. It removes oil, grease, grime and most stains and discolorations. Its biodegradable formula is safe for lawns and pets.\nDoes Coca Cola remove oil stains from concrete?\nWhile often thought of as a myth, cola (like Coca–Cola or Pepsi) can be used to remove oil stains from your driveway. Simply mop up any excess oil and then pour 1-2 cans of cola over the area. Let it sit overnight and in the morning, hose it down.\nWill straight bleach harm concrete?\nWhen applied to concrete, bleach does not harm the sturdy material. It also disinfects concrete. When using bleach, work in a well-ventilated area because the fumes from bleach can be overwhelming. Depending on your cleaning project, you might combine the bleach with detergent, dilute it with water or use it straight.\nHow do you deep clean concrete floors?\n- Remove Surface Dust and Debris. Sweep, vacuum or dust mop regularly to help prevent scratches from dirt and grit.\n- Mix Cleaning Solution and Wet Mop. Weekly, mix two gallons of warm water and two teaspoons dishwashing liquid in a bucket or sink.\n- Rinse and Dry.\nWhat is the best way to clean a concrete garage floor?\nFor regular cleaning, a solution of baking soda and water will loosen dirt and grease and help keep your garage floor clean. Mix a half-cup baking soda in a gallon of warm water and use it as an all-purpose cleaner.\nHow can I make my concrete white again?\nApply vinegar or bleach to the discolored areas. If you use vinegar, do not dilute it. Pour it onto the concrete and scrub it into the surface with a scrub brush. If the discoloration starts to fade, repeat until it disappears completely.\nWhat can you clean concrete floors with?\nSome good cleaners include Castile soap, liquid dish detergent, stone cleaners and mild floor cleaners. Mix a solution, apply to floor with a wet mop and then rinse with a mop dipped in clean water. To make your concrete floors resistant to future stains, apply a concrete sealant.", "domain": "chemistry", "round": 3} +{"url": "https://www.genetex.com/Product/Detail/Borrelia-burgdorferi-Erpd-Arp37-antibody/GTX48808", "date": "2020-11-24T17:28:11Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-50/segments/1606141176922.14/warc/CC-MAIN-20201124170142-20201124200142-00658.warc.gz", "language_score": 0.9222540259361267, "token_count": 425, "dump": "CC-MAIN-2020-50", "global_id": "webtext-fineweb__CC-MAIN-2020-50__0__219958562", "lang": "en", "text": "0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 and 0.01% (w/v) Sodium Azide\nStore as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.\n1 mg/ml (Please refer to the vial label for the specific concentration.)\nMBP-fusion protein corresponding to Borrelia burgdorferi ErpD/Arp37 protein.\nProtein A purified\nFor laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.\nThis product is antibody made against ErpD (ospE/F-Related Protein D), also known as Arp37, from the spirochete Borrelia burgdorferi, which is carried by Ixodes ticks. Erp proteins from Borrelia burgdorferi are postulated to be lipoproteins, based on their predicted amino acid sequences. The spirochete migrates from the tick midgut during feeding to its salivary glands and are thus transmitted to the mammal host. This transition may be facilitated by changes in expression of some B. burgdorferi genes. It is believed that expression of the various proteins associated with the spirochete may be regulated by the changes in tick life cycle, changes in conditions during tick feeding (such as temperature, pH, and nutrients) and/or in coordination with the course of infection of the mammal host. Several studies have demonstrated that infected humans and animals produce antibodies directed against Erp proteins within the first 2-4 weeks of infection, indicative of Erp synthesis during the initial stages of vertebrate infection. It is postulated that surface-exposed Erp proteins could facilitate interactions with host tissues during the establishment of vertebrate infection.", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/arsaasa-antibody-ab77586.html", "date": "2020-09-18T14:39:15Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-40/segments/1600400187899.11/warc/CC-MAIN-20200918124116-20200918154116-00478.warc.gz", "language_score": 0.8137124180793762, "token_count": 1260, "dump": "CC-MAIN-2020-40", "global_id": "webtext-fineweb__CC-MAIN-2020-40__0__201379129", "lang": "en", "text": "Key features and details\n- Goat polyclonal to ARSA/ASA\n- Suitable for: Flow Cyt, IHC-P, WB, ELISA\n- Reacts with: Mouse, Rat, Human\n- Isotype: IgG\nProduct nameAnti-ARSA/ASA antibody\nSee all ARSA/ASA primary antibodies\nDescriptionGoat polyclonal to ARSA/ASA\nTested applicationsSuitable for: Flow Cyt, IHC-P, WB, ELISAmore details\nSpecies reactivityReacts with: Mouse, Rat, Human\nPredicted to work with: Chimpanzee, Rhesus monkey\n- IHC: Human cortex staining WB: Mouse testis lysates and Recombinant Human ARSA/ASA protein (ab116931 Flow Cyt: HeLa cells IF: HeLa cells\nPreviously labelled as ARSA.\nStorage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.\nStorage bufferpH: 7.30\nPreservative: 0.02% Sodium azide\nConstituents: 0.5% BSA, 99% Tris buffered saline\nConcentration information loading...\nPurityImmunogen affinity purified\nPurification notesab77586 is purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.\nOur Abpromise guarantee covers the use of ab77586 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\n|IF||Use a concentration of 10 µg/ml.|\n|Flow Cyt||Use a concentration of 10 µg/ml.|\n|IHC-P||Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.|\n|WB||Use a concentration of 0.3 - 1 µg/ml. Detects a band of approximately 54 kDa (predicted molecular weight: 54 kDa).\n1 hour primary incubation is recommended for this product.\nApprox 60-65Da band observed in Mouse and Rat Testis lysates.\nFunctionHydrolyzes cerebroside sulfate.\nInvolvement in diseaseDefects in ARSA are a cause of leukodystrophy metachromatic (MLD) [MIM:250100]. MLD is a disease due to a lysosomal storage defect. It is characterized by intralysosomal storage of cerebroside-3-sulfate in neural and non-neural tissues, with a diffuse loss of myelin in the central nervous system. Progressive demyelination causes a variety of neurological symptoms, including gait disturbances, ataxias, optical atrophy, dementia, seizures, and spastic tetraparesis. Three forms of the disease can be distinguished according to the age at onset: late-infantile, juvenile and adult.\nArylsulfatase A activity is defective in multiple sulfatase deficiency (MSD) [MIM:272200]. MSD is a disorder characterized by decreased activity of all known sulfatases. MSD is due to defects in SUMF1 resulting in the lack of post-translational modification of a highly conserved cysteine into 3-oxoalanine. It combines features of individual sulfatase deficiencies such as metachromatic leukodystrophy, mucopolysaccharidosis, chondrodysplasia punctata, hydrocephalus, ichthyosis, neurologic deterioration and developmental delay.\nSequence similaritiesBelongs to the sulfatase family.\nmodificationsThe conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. This post-translational modification is severely defective in multiple sulfatase deficiency (MSD).\n- Information by UniProt\n- arsA antibody\n- ARSA_HUMAN antibody\n- arylsulfatase A antibody\nImmunofluorescence analysis of HeLa cells labelling ARSA/ASA with ab77586 at 10 µg/mL. Cells were permeabilized with 0.15% Triton X-100. Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077) at 2 µg/mL was used as the secondary antibody (green). Nuclear DNA was labelled with DAPI (blue). Negative control: Unimmunized goat IgG 10 µg/mL.\nFlow Cytometry analysis of HeLa (human epithelial cell line from cervix adenocarcinoma) cells labelling ARSA/ASA with ab77586 at 10 µg/mL. Cells were permeabilised with 0.5% Triton. Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077) at 1 µg/mL was used as the secondary antibody. Unimmunized goat IgG was used as the isotype control (black).\nImmunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) of human Cortex staining ARSA/ASA with ab77586at 5 μg/ml\nAnti-ARSA/ASA antibody (ab77586) at 0.5 µg/ml + Mouse Testis lysate (in RIPA buffer) at 35 µg\nPredicted band size: 54 kDa\nObserved band size: 54 kDa\nPrimary incubation was 1 hour.\nab77586 has not yet been referenced specifically in any publications.", "domain": "chemistry", "round": 3} +{"url": "https://www.h2-view.com/story/beijing-2022-winter-olympics-buses-to-be-powered-by-hydrogen/2002570.article/", "date": "2024-04-20T07:34:19Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712296817491.77/warc/CC-MAIN-20240420060257-20240420090257-00628.warc.gz", "language_score": 0.8906121850013733, "token_count": 326, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__85534746", "lang": "en", "text": "A fleet of 85 zero emission buses circulating the Olympic Village at the Beijing 2022 Winter Olympics will be fuelled with hydrogen supplied by Cockerill Jingli Hydrogen.\nThe Chinese company, a joint venture between John Cockerill (formerly CMI) and Suzhou Jingli Hydrogen Production Equipment Co., will construct a single-stack electrolyser at Zhangjiakou site with a capacity of 7.5MW – one of the largest electrolysers in the world.\nZhangjiakou is striving to cultivate and grow a hydrogen energy industry and revealed a ‘Hydrogen Energy Zhangjiakou Construction Plan’ back in June:\n- Clarify the advantages and current situation of the development of hydrogen energy in Zhangjiakou, the overall thinking, development goals, main tasks of construction, key projects, industrial spatial layout, economic benefits, social benefits and environment.\n- The hydrogen energy industry will develop into an important pillar of the city.\n- By 2021, it will form an ecosystem covering the preparation, storage and transportation of hydrogen energy, the filling of key equipment for hydrogen fuel cells and the manufacture of key components.\n- Up to 21,000 tonnes, more than 20 enterprises will be introduced into the park, which will become a first-class hydrogen energy city in China.\n- By 2035, the city’s annual hydrogen production capacity will reach 50,000 tonnes, and the park will introduce more than 100 enterprises.\n- Zhangjiakou will be built into an internationally renowned city. The capital of hydrogen energy.\n... to continue reading you must be subscribed", "domain": "chemistry", "round": 3} +{"url": "https://de-mark.com/product/detail/id/164", "date": "2023-06-03T18:46:56Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-23/segments/1685224649302.35/warc/CC-MAIN-20230603165228-20230603195228-00230.warc.gz", "language_score": 0.6930573582649231, "token_count": 399, "dump": "CC-MAIN-2023-23", "global_id": "webtext-fineweb__CC-MAIN-2023-23__0__147658883", "lang": "en", "text": "For Treatment of Swine/Bovine Respiratory Diseases (SRD/BRD)\nContent4%, 10%, 20%\nShelf Life24 months\nPackaging25kg bag or drum\nGeneral information：Florfenicol is a derivative of thiamphenicol. But more active in vitro against many different strains of bacteria, and no worry about blood dyscrasias.\nIndication: It is used for the bacterial diseases in pigs, chickens and fish caused by sensitive bacteria. Such as, respiratory tract infections caused by Pasteurella haemolyticus, typhoid fever caused by Salmonella, chicken cholera, dysentery, colibacillosis and so on.\nPrecaution：Do not administrate in breeding or laying hens producing eggs intended for hatching or human consumption.\nWithdrawal：Broiler 5 days，Swine 20days.\n|FLORDIS Premix 40||4% Florfenicol microencapsulated|\n|FLORDIS Premix 100||10% Florfenicol WSP|\n|FLORDIS Premix 200||20% Florfenicol WSP / coated|\nTylvalosin Tartrate 20%/62.5%\nEnrofloxacin 10%, 20% coated\nEnrofloxacin HCL 5%, 30% water soluble\nDoxycycline Hyclate 10% water soluble\nDoxycycline HCL 20% pellet\nTylosin Tartrate 10% water soluble\nTylosin Phosphate 10% granule\nTiamulin Hydrogen Fumarate 80%/10%\nAmoxicillin 10% solid solution\nLincomycin HCL 4.4% pellet\nWe will contact you within 24 hours.", "domain": "chemistry", "round": 3} +{"url": "https://thereversal.co/blogs/research/a-cell-permeant-mimetic-of-nmn-activates-sarm1-to-produce-cyclic-adp-ribose-and-induce-non-apoptotic-cell-death", "date": "2024-03-05T00:56:22Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707947476592.66/warc/CC-MAIN-20240304232829-20240305022829-00597.warc.gz", "language_score": 0.8670037388801575, "token_count": 802, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__175723394", "lang": "en", "text": "Understanding SARM1: An Enzyme with Key Roles in Cellular Processes\nBiochemistry: Exploring the Building Blocks of Life\n- SARM1 is an enzyme that regulates axonal degeneration and utilizes NAD.\n- CZ-48 is a cell-permeant mimetic of NMN that activates SARM1 in vitro and in cellulo.\n- NMN-adenylyltransferase knockout elevated cellular NMN and activated SARM1 to produce cADPR, confirming NMN as its endogenous activator.\nUnveiling the Catalytic Activities of SARM1 and CD38\n- CZ-48 activates SARM1 by causing a conformational change of the auto-inhibitory domain and dimerization of its catalytic domain.\n- SARM1 catalysis is similar to CD38, despite having no sequence similarity.\n- Both SARM1 and CD38 catalyze a similar set of reactions, but SARM1 has much higher NAD-cyclizing activity, leading to elevated cADPR production.\n- CZ-48 selectively activates SARM1 but inhibits CD38.\nCZ-48: A Specific Modulator of SARM1\n- In cells overexpressing SARM1, CZ-48 increases cADPR levels, depletes NAD and ATP, and induces non-apoptotic death.\n- CZ-48 acts as a specific modulator of SARM1 functions in cells.\nThe Graphical Abstract: A Visual Summary\n- The Graphical Abstract is presented as a separate image or section.\n- It is a concise summary of the research or paper.\n- It uses visuals and graphics to convey key findings or concepts.\n- It is typically located at the beginning of the paper or article.\n- It serves as a visual aid to attract readers' attention and provide an overview of the research.\n- The Graphical Abstract should capture the main points and objectives of the research in a visually appealing and easy-to-understand manner.\nCZ-48: A Powerful Tool for Studying SARM1 and CD38\n- CZ-48 is a compound that can enter cells and mimic the effects of NMN.\n- CZ-48 activates SARM1, a protein involved in cellular processes.\n- CZ-48 has an inhibitory effect on CD38 enzyme activity.\n- SARM1 and CD38 have similar catalytic functions, but SARM1 has higher cyclase activity.\n- Activation of SARM1 by CZ-48 or NMN leads to changes in its conformation.\n- Activation of SARM1 results in the production of cADPR, depletion of NAD, and non-apoptotic cell death.\nInvestigating the Mechanism of SARM1 Activation\n- The study examined the mechanism of SARM1 activation triggered by CZ-48 and NMN.\n- SARM1 is a large molecule that can form constitutive dimers.\n- Activation of SARM1 by CZ-48 leads to the accumulation of cellular cADPR.\n- SARM1 is regulated by NMN and CZ-48 and can induce non-apoptotic cell death.\n- CZ-48 selectively activates SARM1 and inhibits CD38.\nTitle of paper: A Cell-Permeant Mimetic of NMN Activates SARM1 to Produce Cyclic ADP-Ribose and Induce Non-apoptotic Cell Death\nAuthor(s): Zhao ZY, Xie XJ, Li WH, Liu J, Chen Z, Zhang B, Li T, Li SL, Lu JG, Zhang L, Zhang LH, Xu Z, Lee HC, Zhao YJ.\nYear published: 2019\nPublished in: iScience\nOriginal article can be found here.", "domain": "chemistry", "round": 3} +{"url": "http://www.esj.ne.jp/meeting/abst/65/S14-7.html", "date": "2018-12-13T09:27:49Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-51/segments/1544376824601.32/warc/CC-MAIN-20181213080138-20181213101638-00028.warc.gz", "language_score": 0.9420104026794434, "token_count": 365, "dump": "CC-MAIN-2018-51", "global_id": "webtext-fineweb__CC-MAIN-2018-51__0__142258209", "lang": "en", "text": "|| 要旨トップ | 本企画の概要 |||日本生態学会第65回全国大会 (2018年3月、札幌) 講演要旨\nシンポジウム S14-7 （Presentation in Symposium）\nThe recent increase of ground-level ozone (O3) may affect the quality of leaves and consequently affect the degree of grazing by insects. Using a free-air O3 enrichment system, we found lower grazing damages on leaves of Japanese white birch by alder leaf beetle under elevated O3. Contrary to the result found in the field, choice and non-choice style of feeding experiments showed that leaves exposed to elevated O3 were preferred by the leaf beetles due to lower defensive chemical production. To clarify this contradictory phenomenon, we pointed out the possibility of BVOC (Biogenic Volatile Organic Compounds) working as signal chemicals for insects to locate their host plants. In this research, two groups of BVOC, monoterpene (MT, C10H16) and sesquiterpene (SQT, C15H24) were of interest. Although many compounds were emitted from leaves of the birch, both MT and SQT had no significant difference in the basal emission rate regardless of O3 exposure. Therefore, BVOC emission in itself does not work as a factor that changes grazing activity of the leaf beetles, however, the blend ratio of BVOC should be considered. Under elevated O3, BVOC dynamics should be studied considering the reaction with O3 after emitted into the atmosphere.", "domain": "chemistry", "round": 3} +{"url": "https://www.journal.riverpublishers.com/index.php/MCT/article/view/810", "date": "2022-09-27T01:52:07Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-40/segments/1664030334974.57/warc/CC-MAIN-20220927002241-20220927032241-00737.warc.gz", "language_score": 0.7826288938522339, "token_count": 1269, "dump": "CC-MAIN-2022-40", "global_id": "webtext-fineweb__CC-MAIN-2022-40__0__80443822", "lang": "en", "text": "Understanding Hydrogen Sulfide in Inflammation: Opportunities and Challenges\nInflammation is an adaptive response to injury, but uncontrolled inflammation can lead to tissue damage and disease. Research in our laboratory (since confirmed in different laboratories worldwide) has shown that hydrogen sulfide (H2S) acts as a mediator of inflammation in different disease conditions. Learning about a novel mediator of inflammation results in unique opportunities with which to approach inflammatory diseases. At the same time, the complexity of biological systems and translation of research from the bed to the bedside also presents challenges. This Editorial aims to discuss the opportunities and challenges in relation to the role of H2S in inflammation, and the future prospects for this research.\nBhatia M, Wong FL, Fu D, Lau HY, Moochhala S, Moore PK. Role of\nhydrogen sulfide in acute pancreatitis and associated lung injury. FASEB\nJ. 2005; 19: 623–625.\nAng AD, Rivers-Auty J, Hegde A, Ishii I, Bhatia M. The effect of CSE\ngene deletion in caerulein-induced acute pancreatitis in the mouse. Am\nJ PhysiolGastrointest Liver Physiol. 2013; 305: G712–G721.\nBadieiA, Chambers ST, Gaddam RR, Fraser R, Bhatia M. Cystathioninegamma-\nlyase gene silencing with siRNA in monocytes/macrophages\nprotects mice against acute pancreatitis. Appl Microbiol Biotech. 2016;\nZhang H, Zhi L, Moore PK, Bhatia M. The role of hydrogen sulfide in\ncecal ligation and puncture induced sepsis in the mouse. Am J Physiol\nLung Cell Mol Physiol. 2006; 290: L1193–L1201.\nBadiei A, Chambers ST, Gaddam RR, Bhatia M. Cystathionine-gammalyase\ngene silencing with siRNA in monocytes/macrophages attenuates\ninflammation in cecal ligation and puncture-induced sepsis in the mouse.\nJ Biosci. 2016; 41: 87–95.\nGaddam RR, Fraser R, Badiei A, Chambers S, Cogger VC, Le Couteur\nDC, Ishii I, Bhatia M. Cystathionine-gamma-lyase gene deletion protects\nmice against inflammation and liver sieve injury following polymicrobial\nsepsis. PLoS ONE. 2016; 11: e0160521.\nZhang J, Sio SW, Moochhala S, Bhatia M. Role of hydrogen sulfide in\nsevere burn injury-induced inflammation in the mouse. Mol Med. 2010;\nBhatia M, Sidhapuriwala J, Moochhala S, Moore PK. Hydrogen sulphide\nis a mediator of carrageenan-induced hindpaw oedema in the rat. Br J\nPharmacol. 2005; 145:141–144.\nZhi L,AngAD, Zhang H, Moore PK, Bhatia M. Hydrogen sulfide induces\nthe synthesis of pro-inflammatory cytokines in human monocyte cell line\nU937 via ERK-NFκB pathway. J Leuk Biol. 2007; 81: 1322–1332.\nBadiei A, Rivers-Auty J, Ang AD, Bhatia M. Inhibition of hydrogen\nsulfide production by gene silencing attenuates inflammatory activity\nof LPS-activated RAW 264.7 cells. Appl Microbiol Biotech. 2013; 97:\nZhang H, Zhi L, Moochhala S, Moore PK, Bhatia M. Endogenous\nhydrogen sulfide regulates leukocyte trafficking in cecal ligation and\npuncture induced sepsis. J Leuk Biol. 2007; 82: 894–905.\nTamizhselvi R, Moore PK, Bhatia M. Inhibition of hydrogen sulfide\nsynthesis attenuates chemokine production and protects mice against\nacute pancreatitis and associated lung injury. Pancreas. 2008; 36:e24-e31.\nBhatia M, Sidhapuriwala J, Ng SW, Tamizhselvi R, Moochhala S.\nProinflammatory effects of hydrogen sulfide on substance P in caeruleininduced\nacute pancreatitis. J Cell Mol Med. 2008; 12: 580–590.\nAng SF, Moochhala S, Bhatia M. Hydrogen sulfide promotes transient\nreceptor potential vanilloid 1-mediated neurogenic inflammation\nin polymicrobial sepsis. Crit Care Med. 2010; 38: 619–628.\nMuniraj N, Stamp LK, Badiei A, Hegde A, Cameron V, Bhatia M.\nHydrogen sulfide acts as a pro-inflammatory mediator in rheumatic\ndisease. Int J Rheum Dis. 2017; 20: 182–189.\nGaddam RR, Chambers S, Murdoch D, Shaw G, Bhatia M. Circulating\nlevels of hydrogen sulfide and substance Pin patients with sepsis. J Infect.\n; 75: 293–300.\nCopyright on any open access article in Molecular and Cellular Therapies published bythe Institute is retained by the author(s). Authors can grant any third party the right to use\nthe article freely as long as its integrity is maintained and its original authors, citation details and publisher are identified. Please contact the Office of Molecular and Cellular\nTherapies for more information specifically regarding permissions if there are questions.", "domain": "chemistry", "round": 3} +{"url": "http://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0006446.g004", "date": "2017-09-22T06:34:54Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-39/segments/1505818688671.43/warc/CC-MAIN-20170922055805-20170922075805-00567.warc.gz", "language_score": 0.9712119698524475, "token_count": 352, "dump": "CC-MAIN-2017-39", "global_id": "webtext-fineweb__CC-MAIN-2017-39__0__121452109", "lang": "en", "text": "Mobile Phone Radiation Induces Reactive Oxygen Species Production and DNA Damage in Human Spermatozoa In Vitro\nFollowing Percoll fractionation, 5×106 high density, spermatozoa were suspended in 1 ml BWW. The cells were placed in 35 mm Petri dishes and placed inside a waveguide. 5×106 cells in 1 ml BWW were placed outside the waveguide as a control (closed circle). The cells in the waveguide were exposed to 1.8 GHz RF-EMR at SAR levels between 0.4 and 27.5 W/kg (open circles) and all samples were incubated for 16 h at 21°C. Following incubation, Fe2+ and H2O2 was added to cells to act as a positive control, incubated for 1 h, then 100 µl 2 mM DTT/BWW solution was added and incubated for 45 min at 37°C. Cells were fixed and labeled with 100 µl charcoal purified anti-8-OH-dG, FITC tagged antibody at a dilution of 1∶50, incubated at 21°C for 1 h, washed and then assessed by flow cytometry. A, As the power levels were increased, the amount of oxidative DNA damage expressed also increased. A significant amount of oxidative DNA damage was observed in cells exposed to 2.8 W/kg (*p<0.05) RF-EMR and above (**p<0.01; ***p<0.001). Results are based on 4 independent samples. B, The levels of 8-OH-dG expression were positively correlated with the levels of ROS generation by the mitochondria (R2 = 0.727).", "domain": "chemistry", "round": 3} +{"url": "https://www.urdupoint.com/dictionary/english-to-urdu/slag-meaning-in-urdu/81373.html", "date": "2021-11-30T14:43:50Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-49/segments/1637964359037.96/warc/CC-MAIN-20211130141247-20211130171247-00214.warc.gz", "language_score": 0.8766898512840271, "token_count": 354, "dump": "CC-MAIN-2021-49", "global_id": "webtext-fineweb__CC-MAIN-2021-49__0__13109058", "lang": "en", "text": "Slag Meaning In Urdu\nSlag Meaning in English to Urdu is دھات کا میل, as written in Urdu and Dhaat Ka Mail, as written in Roman Urdu. There are many synonyms of Slag which include Ashes, Cinders, Dross, Lava, Refuse, Residue, Scoria, Recrement, etc.\nدھات کا میل\nDhaat Ka Mail\n|Dhaat Ka Mail||دھات کا میل|\nDefinitions of Slag\nn. The dross, or recrement, of a metal; also, vitrified cinders.\nn. The scoria of a volcano.\nn. A product of smelting, containing, mostly as silicates, the substances not sought to be produced as matte or metal, and having a lower specific gravity than the latter; -- called also, esp. in iron smelting, cinder. The slag of iron blast furnaces is essentially silicate of calcium, magnesium, and aluminium; that of lead and copper smelting furnaces contains iron.\nv. To form, or form into, a slag; to agglomerate when heated below the fusion point.\nHow To Spell Slag [slag]\nOrigin of Slag Mid 16th century: from Middle Low German slagge, perhaps from slagen ‘strike’, with reference to fragments formed by hammering. The verb sense ‘criticize’ dates from the 1970s.", "domain": "chemistry", "round": 3} +{"url": "https://pmiweb.ornl.gov/portfolio/uw/", "date": "2023-12-07T07:48:54Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100650.21/warc/CC-MAIN-20231207054219-20231207084219-00534.warc.gz", "language_score": 0.9083934426307678, "token_count": 482, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__214172430", "lang": "en", "text": "Structural basis for a bacterial Pip system plant effector recognition protein\nShukun Luo, Bruna G. Coutinho, Prikshat Dadhwal, Yasuhiro Oda, Jiahong Ren, Amy L. Schaefer, E. Peter Greenberg, Caroline S. Harwood, and Liang Tong\n09 March 2021, PNAS 118(10): e2019462118; https://doi.org/10.1073/pnas.2019462118\nA number of plant-associated proteobacteria have LuxR family transcription factors that we refer to as PipR subfamily members. PipR proteins play roles in interactions between bacteria and their plant hosts, and some are important for bacterial virulence of plants. We identified an ethanolamine derivative, N-(2-hydroxyethyl)-2-(2-hydroxyethylamino) acetamide (HEHEAA), as a potent effector of PipR-mediated gene regulation in the plant endophyte Pseudomonas GM79. HEHEAA-dependent PipR activity requires an ATP-binding cassette-type active transport system, and the periplasmic substrate-binding protein (SBP) of that system binds HEHEAA. To begin to understand the molecular basis of PipR system responses to plant factors we crystallized a HEHEAA-responsive SBP in the free- and HEHEAA-bound forms. The SBP, which is similar to peptide-binding SBPs, was in a closed conformation. A narrow cavity at the interface of its two lobes is wide enough to bind HEHEAA, but it cannot accommodate peptides with side chains. The polar atoms of HEHEAA are recognized by hydrogen-bonding interactions, and additional SBP residues contribute to the binding site. This binding mode was confirmed by a structure-based mutational analysis. We also show that a closely related SBP from the plant pathogen Pseudomonas syringae pv tomato DC3000 does not recognize HEHEAA. However, a single amino acid substitution in the presumed effector-binding pocket of the P. syringae SBP converted it to a weak HEHEAA-binding protein. The P. syringae PipR depends on a plant effector for activity, and our findings imply that different PipR-associated SBPs bind different effectors.", "domain": "chemistry", "round": 3} +{"url": "https://www.istc.int/en/projects?status=3&by=location&s_loc=Chernogolovka&s_inst=8667", "date": "2021-05-07T19:14:51Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-21/segments/1620243988802.93/warc/CC-MAIN-20210507181103-20210507211103-00589.warc.gz", "language_score": 0.8109136819839478, "token_count": 358, "dump": "CC-MAIN-2021-21", "global_id": "webtext-fineweb__CC-MAIN-2021-21__0__122420578", "lang": "en", "text": "New Generation of X-ray Focusing System for Advanced Technologies and Basic Research\nDevelopment of Superconducting and Magnetic Molecular Devices Based on Carbon Nanotubes and DNA Molecules\nStructurally Perfect Metal-Oxide Superconductors of the Y-Ba-Cu-O System with Improved Superconducting Characteristics\nNanostructural Superconducting Metal-Oxide Materials\nOxide Nanomaterials for Lithium-Ion Batteries\nDevelopment and Testing of Nanostructured Oxide Materials for Rechargeable Lithium-Ion Batteries\nBroad-Band X-Ray Spectrograph Based on a Cylindrically Bending Multilayer Mirror with a Laterally Graded Period\nNew Nanosized and Thin Films Oxides Phosphors for Visualization and Emitting Flat Display\nNew Materials and Heterostructures for Conductometric Sensors of Fluorine and Hydrogen Fluoride\nInvestigation of Onion-Like Carbon Nanoparticles Produced from Nanodiamonds of Detonation Synthesis and Development of Composites with their Application\nStudy of the Effect of Space Factors on the \"Silicon-on-Insulator\" Structure and Microelectronic Elements on Its Basis Using the Yerphi Facility Modeling the Space Exposure\nThe International Science and Technology Center (ISTC) is an intergovernmental organization connecting scientists from Kazakhstan, Armenia, Tajikistan, Kyrgyzstan, and Georgia with their peers and research organizations in the EU, Japan, Republic of Korea, Norway and the United States.\nISTC facilitates international science projects and assists the global scientific and business community to source and engage with CIS and Georgian institutes that develop or possess an excellence of scientific know-how.", "domain": "chemistry", "round": 3} +{"url": "https://www.ars.usda.gov/research/publications/publication/?seqNo115=106621", "date": "2017-10-21T11:08:38Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-43/segments/1508187824733.32/warc/CC-MAIN-20171021095939-20171021115939-00327.warc.gz", "language_score": 0.9206022024154663, "token_count": 286, "dump": "CC-MAIN-2017-43", "global_id": "webtext-fineweb__CC-MAIN-2017-43__0__72669475", "lang": "en", "text": "Submitted to: Improving Phosphorous Acquisition Efficiency in Marginal Soils Proceedings\nPublication Type: Proceedings\nPublication Acceptance Date: 3/7/2000\nPublication Date: N/A\nCitation: N/A Interpretive Summary:\nTechnical Abstract: Two of the major factors limiting crop production on acid soils are aluminum (Al) toxicity and phosphorus (P) deficiency. Over the past 10 years, considerable research has focused on the basic biology of aluminum toxicity and tolerance. The attention on fundamental mechanisms of aluminum tolerance has resulted in some significant progress in the identification of the underlying processes certain crop plant genotypes employ to tolerate toxic levels of Al3+ in acid soils. Possibly because of progress in research on Al tolerance, some acid soil researchers are starting to expand their research focus to include elucidation of the fundamental mechanisms and genes controlling P efficiency, which is the ability of certain crop genotypes to function well under low P conditions. Because crop plants growing on acid soils must usually deal with the dual stresses of excess Al and not enough P, it has been speculated that the Al tolerance and P efficiency traits may somehow be linked. In this paper, I will review the insights our research group and other researchers have gained in understanding of Al tolerance mechanisms in cereal crops, and come to the conclusion that the mechanisms plants employ to tolerate Al in the soil are separate and distinct from those that facilitate P efficiency.", "domain": "chemistry", "round": 3} +{"url": "https://eyescoops.ca/what-is-nmn-supplement-benefits-and-site-effects/", "date": "2023-09-24T04:53:55Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233506559.11/warc/CC-MAIN-20230924023050-20230924053050-00393.warc.gz", "language_score": 0.9507063031196594, "token_count": 254, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__243695792", "lang": "en", "text": "What is NMN Supplement and How Does it Work?\nNMN, or nicotinamide mononucleotide, is a naturally occurring compound found in the body that plays an important role in energy production and metabolism. It is a precursor to NAD+, a coenzyme that helps cells convert food into energy. As we age, our bodies produce less and less NAD+, leading to a decrease in energy production and metabolism.\nNMN supplements are designed to help replenish the body’s NAD+ levels, which can help improve energy production and metabolism. Studies have shown that NMN supplements can help improve physical performance, reduce fatigue, and even slow down the aging process.\nNMN supplements are easy to take and can be taken in pill or powder form. They are also safe and have few side effects. Taking NMN supplements can help you feel more energized and youthful, and can even help you live a longer, healthier life.\nSo if you’re looking for a way to boost your energy and metabolism, NMN supplements may be the answer. With their natural, safe, and easy-to-take form, they can help you feel more energized and youthful, and can even help you live a longer, healthier life.", "domain": "chemistry", "round": 3} +{"url": "https://www.e3s-conferences.org/articles/e3sconf/abs/2019/34/e3sconf_ef18_02006/e3sconf_ef18_02006.html", "date": "2021-06-18T06:47:25Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-25/segments/1623487635724.52/warc/CC-MAIN-20210618043356-20210618073356-00499.warc.gz", "language_score": 0.8928403854370117, "token_count": 621, "dump": "CC-MAIN-2021-25", "global_id": "webtext-fineweb__CC-MAIN-2021-25__0__132224129", "lang": "en", "text": "E3S Web Conf.\nVolume 108, 2019Energy and Fuels 2018\n|Number of page(s)||7|\n|Published online||05 July 2019|\nApplication of aluminum-based coagulants for improving efficiency of flue gas desulfurization wastewater treatment in coal – fired power plant\nWarsaw University of Technology Faculty of Building Services, Hydro and Environmental Engineering, Nowowiejska 20, 00-653 Warsaw, Poland\n2 Enea Wytwarzanie sp. z.o.o, Chemical Laboratories, Kozienice Power Plant, Świerże Górne, Al. Józefa Zielińskiego 1, 26-900 Kozienice, Poland\n* Corresponding author: firstname.lastname@example.org\nPollution released into the environment as the result of the combustion of energy fuels is a significant global threat. For instance, wastewater in coal–fired power plants is often heavily polluted by organic compounds, heavy metals and boron. Therefore, there is an urgent need for efficient flue gases and wastewater treatment. However, to be industrially implemented, the treatment processes have to be simultaneously effective and inexpensive. This research systematically studied the efficiency of inexpensive coagulation processes using aluminum-based coagulants applied to flue gas desulfurization (FGD) wastewater treatment. Additionally, the differences in the efficiency of total organic carbon (TOC) and chemical oxygen demand (COD) removal between sedimentation and coagulation processes were systematically studied. It was found that coagulation with the appropriate dose of PAX19XL coagulant achieved a satisfactory effect with significant boron removal and almost complete heavy metals removal. The polyelectrolyte use did not improve coagulation effectiveness and did not accelerate sludgesedimentation and volume decreasing. The detailed statistical analyses did not confirm the positive, pronounced effect of coagulation compared to sedimentation, although there were observed exceptions that should be considered separately. The results obtained suggest that inexpensive aluminum-based coagulants may be effective in improving the efficiency of flue gas desulfurization wastewater treatment in coal–fired power plants.\n© The Authors, published by EDP Sciences, 2019\nThis is an open access article distributed under the terms of the Creative Commons Attribution License 4.0 (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.\nCurrent usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.\nData correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.\nInitial download of the metrics may take a while.", "domain": "chemistry", "round": 3} +{"url": "https://repub.eur.nl/pub/13161", "date": "2023-05-31T09:27:16Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-23/segments/1685224646457.49/warc/CC-MAIN-20230531090221-20230531120221-00263.warc.gz", "language_score": 0.8442203998565674, "token_count": 739, "dump": "CC-MAIN-2023-23", "global_id": "webtext-fineweb__CC-MAIN-2023-23__0__150545513", "lang": "en", "text": "Characterization of rat iodothyronine sulfotransferases.\nAmerican Journal of Physiology: Endocrinology and Metabolism p. 592- 598\nSulfation appears to be an important pathway for the reversible inactivation of thyroid hormone during fetal development. The rat is an often used animal model to study the regulation of fetal thyroid hormone status. The present study was done to determine which sulfotransferases (SULTs) are important for iodothyronine sulfation in the rat, using radioactive T4, T3, rT3, and 3,3'-T2 as substrates, 3'-phosphoadenosine-5'-phosphosulfate (PAPS) as cofactor, and rat liver, kidney and brain cytosol, and recombinant rat SULT1A1, -1B1, -1C1, -1E1, -2A1, -2A2, and -2A3 as enzymes. Recombinant rat SULT1A1, -1E1, -2A1, -2A2, and -2A3 failed to catalyze iodothyronine sulfation. For all tissue SULTs and for rSULT1B1 and rSULT1C1, 3,3'-T2 was by far the preferred substrate. Apparent Km values for 3,3'-T2 amounted to 1.9 microM in male liver, 4.4 microM in female liver, 0.76 microM in male kidney, 0.23 microM in male brain, 7.7 microM for SULT1B1, and 0.62 microM for SULT1C1, whereas apparent Km values for PAPS showed less variation (2.0-6.9 microM). Sulfation of 3,3'-T2 was inhibited dose dependently by other iodothyronines, with similar structure-activity relationships for most enzymes except for the SULT activity in rat brain. The apparent Km values of 3,3'-T2 in liver cytosol were between those determined for SULT1B1 and -1C1, supporting the importance of these enzymes for the sulfation of iodothyronines in rat liver, with a greater contribution of SULT1C1 in male than in female rat liver. The results further suggest that rSULT1C1 also contributes to iodothyronine sulfation in rat kidney, whereas other, yet-unidentified forms appear more important for the sulfation of thyroid hormone in rat brain.\n|, , , , , , , , , , , ,|\n|American Journal of Physiology: Endocrinology and Metabolism|\n|Organisation||Erasmus MC: University Medical Center Rotterdam|\nKester, M.H.A, Kaptein, E, Roest, T.J, van Dijk, C.H, Tibboel, D, Meinl, W, … Visser, T.J. (2003). Characterization of rat iodothyronine sulfotransferases. American Journal of Physiology: Endocrinology and Metabolism, 592–598. doi:10.1152/ajpendo.00046.2003", "domain": "chemistry", "round": 3} +{"url": "https://www.hindawi.com/journals/isrn/2012/658508/ref/", "date": "2017-03-24T00:22:52Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-13/segments/1490218187227.84/warc/CC-MAIN-20170322212947-00554-ip-10-233-31-227.ec2.internal.warc.gz", "language_score": 0.7620965242385864, "token_count": 992, "dump": "CC-MAIN-2017-13", "global_id": "webtext-fineweb__CC-MAIN-2017-13__0__14075498", "lang": "en", "text": "- About this Journal ·\n- Abstracting and Indexing ·\n- Aims and Scope ·\n- Article Processing Charges ·\n- Articles in Press ·\n- Author Guidelines ·\n- Bibliographic Information ·\n- Citations to this Journal ·\n- Contact Information ·\n- Editorial Board ·\n- Editorial Workflow ·\n- Free eTOC Alerts ·\n- Publication Ethics ·\n- Reviewers Acknowledgment ·\n- Submit a Manuscript ·\n- Subscription Information ·\n- Table of Contents\nVolume 2012 (2012), Article ID 658508, 5 pages\nCharacterization, Acid Activation, and Bleaching Performance of Ibeshe Clay, Lagos, Nigeria\nDepartment of Chemical Engineering, University of Lagos, Lagos 101017, Nigeria\nReceived 23 December 2011; Accepted 11 January 2012\nAcademic Editor: P. Weisbecker\nCopyright © 2012 M. A. Usman et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.\n- K. Baranowsky, W. Beyer, G. Billek et al., “Technologies for industrial processing of fats and oils,” European Journal of Lipid Science and Technology, vol. 103, pp. 505–551, 2001.\n- L. L. Richardson, “Use of bleaching, clays, in processing edible oils,” Journal of the American Oil Chemists' Society, vol. 55, no. 11, pp. 777–780, 1978.\n- A. O. Oboh, O. C. Aworhi, and O. K. Agagu, “The use of Nigerian clays in vegetable oil refining: evaluation of some Nigerian clays as potential bleaching earths,” Nigerian Food Journal, vol. 5, pp. 42–51, 1987.\n- D. F. Valenzuela and S. P. De Souza, “Studies on the acid activation of Brazilian smectitic clays,” Quimica Nova, vol. 24, no. 3, pp. 345–353, 2001.\n- L. H. Wiedermann, “Degumming, refining and bleaching soybean oil,” Journal of the American Oil Chemists' Society, vol. 58, no. 3, pp. 159–166, 1981.\n- “Young’s Corporation, User’s Guide of Activated Clay,” http://www.youngscorp.com/.\n- D. A. Morgan, D. B. Shaw, M. J. Sidebottom, T. C. Soon, and R. S. Taylor, “The function of bleaching earths in the processing of palm, palm kernel and coconut oils,” Journal of the American Oil Chemists' Society, vol. 62, no. 2, pp. 292–299, 1985.\n- F. D Snell and L. S. Ettre, Enclopedia of Industrial Chemical Analysis, Interscience, London, UK, 1969.\n- ISO, “Animal and Vegetable Fats and Oils—Determination of Iodine Value,” British Standard number 3961, 1999.\n- Z. Wu, C. Li, X. Sun et al., “Characterization, acid activation and bleaching performance of bentonite from Xinjiang,” Chinese Journal of Chemical Engineering, vol. 14, no. 2, pp. 253–258, 2006.\n- D. W. Breck, Zeolite Molecular Sieve Structure, Chemistry and Uses, Wiley Inter Science, New York, NY, USA, 1974.\n- K. M. M. Motlagh, A. Z. Rigi, and A. A. Yuzbashi, “To Evaluate an Acid Activated Bentonite from Khorasani (Iran) for Use as a Bleaching Clay, IUST International,” Journal of Engineering Science, vol. 5, no. 2, pp. 83–87, 2008.\n- S. Arfaoui, N. Frini-Srasra, and E. Srasra, “Modelling of the adsorption of the chromium ion by modified clays,” Desalination, vol. 222, no. 1-3, pp. 474–481, 2008.\n- D. D. Brooks, “Bleaching Factors that Affect the Oil Loss,” in Proceedings of the PORIM International Palm Oil Congress (Chemistry and Technology), pp. 45–51, 1999.", "domain": "chemistry", "round": 3} +{"url": "https://www.semanticscholar.org/paper/Zip1-Zip2-and-Zip8-mRNA-Expressions-Were-Associate-Sun-Wang/1f02510077ccf095ef3d3eee19c26b8dfb271329", "date": "2017-12-15T03:43:36Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-51/segments/1512948563083.64/warc/CC-MAIN-20171215021156-20171215041156-00015.warc.gz", "language_score": 0.958654522895813, "token_count": 370, "dump": "CC-MAIN-2017-51", "global_id": "webtext-fineweb__CC-MAIN-2017-51__0__200700557", "lang": "en", "text": "Short stature of children is affected by multiple factors. One of them is growth hormone (GH) deficiency. Growth hormone therapy can increase the final height of children with growth hormone deficiency. Zinc is found to induce dimerization and to enhance the bioactivity of human GH. Two gene families have been identified involved in zinc homeostasis. Previous studies in our laboratory have shown that Zip1, Zip2, Zip6, and ZnT1 mRNA were associated with zinc level in established human breast cancer in nude mice model; Zip8 was significantly lower in zinc-deficient Wistar rats in kidney. In this study, five zinc transporters: Zip1, Zip2, Zip6, Zip8, and ZnT1 were chosen. We aimed to investigate the mRNA expression of zinc transporters and to explore the relationship between zinc transporters and growth hormone in short stature children. Growth hormone provocation test is used to confirm the diagnosis of growth hormone deficiency. Six short children for the test were enrolled. At the same time, 15 sex- and age-matched normal children were enrolled as control. The expression levels of zinc transporters in peripheral blood mononuclear cells were determined by quantitative real-time PCR. Zip1 and Zip2 mRNA expression positively correlated with growth hormone level (r = 0.5133, P = 0.0371; r = 0.6719, P = 0.0032); Zip8 mRNA expression negatively correlated with growth hormone level (r = −0.5264, P = 0.0285) during the test in short stature children. The average expression level of Zip2 was significantly higher and Zip6, Zip8 mRNA levels were significantly lower in short stature children than in health controls at 0 min (P < 0.05, P < 0.05).", "domain": "chemistry", "round": 3} +{"url": "https://liveconscience.com/2018/11/03/the-rnap-may-be-the-jaw-domain-name-which-is-area/", "date": "2023-12-01T09:49:05Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100286.10/warc/CC-MAIN-20231201084429-20231201114429-00218.warc.gz", "language_score": 0.9089570045471191, "token_count": 1117, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__228529620", "lang": "en", "text": "The RNAp may be the jaw domain name, which is area of the DNA binding channel. R56C, can productively infect this stress. By learning the molecular basis of inhibition of RNAp from your 7009 stress by Gp2, we offer many lines of proof that this E24K and F27Y substitutions facilitate an conversation with RNAp when the principal conversation user interface using the jaw is usually compromised. The suggested additional 212200-21-0 manufacture conversation user interface between RNAp and Gp2 may donate to the multipronged system of transcription inhibition by Gp2. Intro Central towards the rules of bacterial transcription may be the RNA polymerase (RNAp), the enzyme in charge of the formation of all RNA in bacterias. The bacterial RNAp comprises a multisubunit catalytic primary (subunit structure 2; abbreviated E) and a sigma () element subunit that determines the specificity from the RNAp-promoter conversation. In RNAp (Nechaev & Severinov, 1999). The jaw domain can be an integral element of the dwDBC and takes on a major part during RPo formation and steady maintenance of the RPo (Ederth RNAp residues 1153C1213), MBP two invariant arginine residues (R56 and R58; R56 and R58 are invariant in 25 and 23, respectively, out of 25 Gp2-like protein in the EBI data source during writing) situated in the 3 strand of Gp2 are near E1158 and E1188 in the jaw, and therefore donate to significant ionic relationships across the user interface (Fig. 1a, b) (Wayne RNAp jaw domain name fragment (residues 1153C1213) complicated. Gp2 is usually demonstrated in cyan as well as the jaw domain name fragment is usually demonstrated in green. The positions from the proteins E24, F27 and R56 in T7 Gp2 are indicated combined with the E1158 and E1188 residues in the jaw domain. (b) Positioning of amino acidity sequences from known Gp2-like protein. The sequences are shown in single-letter amino acidity code, with the space from the series indicated around the much correct. The localization from the -strands and -helix predicated on the framework of T7 Gp2 is usually indicated. The extremely conserved R56 and R58 residues are highlighted in blue. The positions of proteins residues E24 and F27 in T7 Gp2 are underlined and in strong type. The arginine residue, related to T7 Gp2 amino acidity residue S23 in Gp2-like proteins in phages CR8, CR44b, K1F and EcoDS1, can be underlined in strong type. (c) Positioning from the jaw domain name amino acidity residues 1153C1213 from a consultant set of sponsor RNAps, with those contaminated by T7-like phages encoding Gp2-like protein indicated by asterisks. Amino acidity residues related to E1158 and E1188 from the RNAp are demonstrated in strong type. (d) As 212200-21-0 manufacture with (a), except the fact that structural types of Gp2-like protein CR44b_13 (orange) and CR8_16 (red) are superimposed and amino acidity residue R15 is certainly indicated. The structural types of the Gp2 homologues had been computed with swiss-model using NMR buildings of T7 Gp2 being a template (Arnold 7009 (Chamberlin, 1974; Nechaev & Severinov, 1999; Schmitt stress (that includes a mutant RNAp formulated with the E1188K substitution in the jaw domain name), encodes a triple mutant type of Gp2 (harbouring substitutions E24K, F27Y and R56C; hereafter known as Gp2) (Chamberlin, 1974; Schmitt bacterial development attenuation assay to measure the activity of recombinant Gp2 on RNAp in the lack of T7 contamination, to review the molecular basis where Gp2 inhibits wild-type, 7009 and BR3 RNAp. The outcomes strongly claim that the E24K and F27Y mutations facilitate the conversation between Gp2 and RNAp when the principal conversation user interface between Gp2 and RNAp is 212200-21-0 manufacture usually compromised. Experiments dealing with the loop interconnecting 1 and 2 strands in Gp2 homologues from two T7-like phages that infect additional corroborate our outcomes. Strategies Bacterial strains and plasmids. Desk S1 (obtainable with the web version of the paper) lists the bacterial strains and plasmids found in this research. Plasmid personal computers1?:?Gp2 and derivatives were constructed by digesting pSW33?:?Gp2 (and derivatives) with was cloned in to the same sites in pBAD18 (Invitrogen). The coding sequences of Gp2 homologues CR44b proteins 13 (CR44b_13) and CR8 proteins 16 (CR8_16) had been PCR-amplified from phage genomic DNA (kindly supplied by Ana Louisa.", "domain": "chemistry", "round": 3} +{"url": "http://core-cms.prod.aop.cambridge.org/core/search?filters%5BauthorTerms%5D=Hedley%20Freake&eventCode=SE-AU", "date": "2023-06-02T09:13:57Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-23/segments/1685224648465.70/warc/CC-MAIN-20230602072202-20230602102202-00410.warc.gz", "language_score": 0.8999602794647217, "token_count": 314, "dump": "CC-MAIN-2023-23", "global_id": "webtext-fineweb__CC-MAIN-2023-23__0__40682381", "lang": "en", "text": "Green tea catechins are known to have hypocholesterolaemic effects in animals and human subjects. In the present study, we investigated the effects of green tea catechins on the mRNA level and promoter activity of hepatic cholesterol 7α-hydroxylase (CYP7A1), the rate-limiting enzyme in the conversion of cholesterol to bile acids, in human hepatoma cells. Real-time PCR assays showed that different catechins, ( − )-epicatechin gallate (ECG), ( − )-epigallocatechin-3-gallate (EGCG), ( − )-epigallocatechin (EGC) and ( − )-epicatechin (EC), up regulated the CYP7A1 mRNA level by 5·5-, 4·2-, 2·9- and 1·9-fold, respectively, compared with the control. The − 1312/+358 bp of the CYP7A1 promoter was subcloned into the pGL3 basic vector that includes luciferase as a reporter gene. ECG or EGCG significantly increased CYP7A1 promoter activity by 6·0- or 4·0-fold, respectively, compared with the control. Also, EGCG stimulated CYP7A1 at both mRNA level and promoter activity in a dose-dependent manner. These results suggest that the expression of the CYP7A1 gene may be directly regulated by green tea catechins at the transcriptional level.", "domain": "chemistry", "round": 3} +{"url": "https://interwaterlife.com/2023/10/28/david-sinclair-nmn-2/", "date": "2024-02-28T13:41:29Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707947474715.58/warc/CC-MAIN-20240228112121-20240228142121-00246.warc.gz", "language_score": 0.9359608292579651, "token_count": 552, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__29159095", "lang": "en", "text": "Each day, we a little older, a tad bit more wrinkly, as well as perhaps a little more forgetful. Caring for our physical and mental health becomes much more critical as we grow older.\nYou may think this is just area of the deal and there’s nothing that you can do to alter it. Luckily, there is a method to decelerate this speeding train that is certainly aging with all-natural NMN supplements.\nWithin this review, we’ll breakdown what NAD+ is and exactly how it affects your system, present some natural remedies to enhance your NAD+ levels, and fully explore the top NMN supplement around – GenF20 Liposomal NMN+.\nAfter this short article, you’ll be ready to reclaim your youth and luxuriate in a prolonged life. Before we waste more precious seconds, let’s read why NAD+ is the key to unlocking aging.\nNicotinamide Adenine Dinucleotide (NAD+) is really a molecule linked to aging. It can be available in abundant quantities inside our bodies when we are younger, but significantly declines as we age. NAD+ helps regulate countless biological functions during the entire body, from mitochondrial to libido to metabolic function.\nIn line with the Journal of Advanced Research, all-natural process of getting older is,\n“Identified by downregulation of energy production in mitochondria of various organs like brain, adipose tissue, skin, liver, skeletal muscle, and pancreas due to the depletion of NAD+.”?\nOut of this, scientists have inferred that by raising NAD+ levels in your bodies, we can experience significant anti-aging benefits on the cellular level. As discussed later in this post, multiple studies support claims that supplementing with NMN might help boost NAD+ levels.\nNatural Solutions to Increase Your NAD+ Levels\nThere are lots of research-backed methods to increase your NAD+ levels. Several methods are simple to incorporate into the way of life, though they could only lead to nominal increases and don’t are quickly as others.\nListed here are a few of the commonly accepted natural means of increasing NAD+ levels:\nLow-calorie or keto diets\nLimit sun exposure\nThe quickest way to enhance your NAD+ levels would be to take supplements. Nicotinamide mononucleotide (NMN) supplements help elevate NAD+ returning to youthful levels. Most NMN supplements contain the same ingredients or some variation thereof. They may can be found in pill or capsule form, powders, or solutions, but the primary ingredient is obviously NMN.\nFor more info about nmn supplement benefits you can check our new webpage", "domain": "chemistry", "round": 3} +{"url": "https://augusta.elsevierpure.com/en/projects/an-epsilon-pkc-interacting-protein-in-preconditioning", "date": "2023-12-07T17:48:05Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100677.45/warc/CC-MAIN-20231207153748-20231207183748-00867.warc.gz", "language_score": 0.8661769032478333, "token_count": 649, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__93301404", "lang": "en", "text": "DESCRIPTION (provided by applicant): The epsilon protein kinase C (epsilonPKC) isozyme has been clearly established as a key mediator of cardiac preconditioning (PC). It is therefore of great interest to study the molecular mechanisms of epsilonPKC-selective signaling to better understand how it mediates protection and to identify potential avenues for the development of epsilonPKC-selective therapeutic modulators of PC. Our current studies indicate that in vitro phosphorylation of an approximately 18 kDa protein found in the particulate cell fraction of cardiac myocytes can be used as a marker of epsilonPKC activation and epsilonPKC-mediated PC. Peptide mass spectrometry and immunoprecipitation analyses have determined that this protein is the IV subunit of cytochrome c oxidase (COIV). Further, this protein is likely an in vivo substrate of epsilonPKC in neonatal cardiac myocytes (NCMs). We hypothesize that COIV plays a key and previously uncharacterized role in cardiac protection against ischemia. Previously we demonstrated that 3 nM 4-beta PMA treatment preferentially activates the epsilonPKC isozyme in NCMs. In this proposal we will determine if epsilonPKC can regulate cytochrome c activity and relate these findings to cardiac PC. We will isolate mitochondria and submitochondrial fractions from NMCs subjected to 3 nM 4-beta PMA treatment and hypoxic PC and monitor cytochrome c oxidase activity, epsilonPKC binding to or phosphorylation of COIV, confocal and electron microscopy COIV and epsilonPKC co-localization studies and mass spectrometric, Cy dye and Pro-Q Diamond methodologies to identify phospho-proteins. Similar analyses will be performed on mitochondria and mitochondrial fractions isolated from adult rat hearts subjected to ischemic PC. The specific aims of this proposal will be: Aim i: To determine the effects of epsilonPKC on cytochrome c oxidase in neonatal cardiac myocytes.; Aim ii To determine the role of epsilonPKC modulation of cytochrome c oxidase in neonatal cardiac myocyte preconditioning and Aim iii: To determine the role of epsilonPKC in the modulation of cytochrome c oxidase in adult rat myocardium exposed to ischemia/reperfusion and ischemic preconditioning. Our work will focus on a novel mechanistic event in the PC paradigm modulated by the epsilonPKC isozyme. A better understanding of the molecular and cellular epsilonPKC targets involved in PC will improve opportunities for the therapeutic application of cardioprotective strategies for patients at risk for myocardial infarction.\n|Effective start/end date||6/1/05 → 4/30/10|\n- National Heart, Lung, and Blood Institute\nExplore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.", "domain": "chemistry", "round": 3} +{"url": "http://www.thelubepage.com/amsoil-synthetics-product-information-list/synthetic-transmission-fluid", "date": "2013-12-09T20:28:49Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2013-48/segments/1386163997905/warc/CC-MAIN-20131204133317-00094-ip-10-33-133-15.ec2.internal.warc.gz", "language_score": 0.8832066059112549, "token_count": 845, "dump": "CC-MAIN-2013-48", "global_id": "webtext-fineweb__CC-MAIN-2013-48__0__122780658", "lang": "en", "text": "AMSOIL Synthetic Universal Automatic Transmission Fluid (ATF) is engineered to outperform conventional automatic transmission fluids and exceed the performance requirements of most North American, European and Asian vehicles. This sophisticated formulation pro vides outstanding performance and protection in the severe operat ing conditions of today’s most advanced transmission designs.\nAutomatic transmissions have become increasingly complex as vehicle manufacturers strive to improve efficiency while satisfying consumer demands. Smaller, smoother-shifting transmissions with longer fluid-life capabilities and heavier load capacities are now standard in modern transmission design. Traditional ATFs, however, are unable to meet these extreme requirements, and new fluids have emerged with each new advancement in transmission engineering. AMSOIL first introduced a synthetic automatic transmission fluid in 1980 and remains the leader in transmission fluid quality. AMSOIL Synthetic Universal ATF is formulated with the highest-quality synthetic fluids and additives. It exceeds the most stringent industry standards and is universally recommended for a wide range of transmissions. AMSOIL Synthetic Universal ATF reduces confusion, misapplications and inventories. It eliminates the need for costly and suspect “one-treatment-coversall” additives. The quality and performance of AMSOIL Synthetic Universal ATF is guaranteed.\nThermal Stability – Hot temperatures are no excuse for poor reliability. Naturally heat resistant and heavily fortified with anti-oxidants, AMSOIL ATF exceeds the most demanding oxidation requirements. AMSOIL ATF delivers outstanding protection against sludge and varnish deposits that clog narrow oil passages and contribute to clutch glazing. Transmissions can operate hotter and longer with AMSOIL ATF than with conventional fluids.\nAMSOIL ATF resists oxidation two times longer than requiredfor petroleum ATFs.\nCold-Temperature Fluidity – Cold, thick automatic transmission fluid lengthens shift times and reduces energy efficiency (fuel economy). AMSOIL Synthetic ATF is wax-free and delivers extraordinary cold-flow properties (< -60°F pour point). Shifting is more responsive, energy efficiency is improved and warm-up times are reduced.\nVarying speeds and loads causes torque multiplication and extreme stress on gears and bearings. To prevent wear damage consistent with low-quality fluid and ruptured fluid film, AMSOIL formulated Synthetic Universal ATF with high film strength (shear stability) and premium anti-wear/extreme-pressure additives (boundary film barrier). AMSOIL Synthetic ATF protects transmissions during severe-duty service.\nToday’s transmissions are smaller and must withstand higher horsepower and torque while delivering smoother shifts, all with longer fluid life recommendations. AMSOIL Synthetic ATF is formulated with friction modifier additives that deliver outstanding clutch-holding capacity (static friction), torque-transfer ability (dynamic friction) and anti-shudder properties (slipping torque converter clutches).\nMost drivers are unaware that transmissions commonly operate under severe service and require shorter fluid drain intervals. AMSOIL Synthetic Universal ATF is a long-life fluid capable of extended service intervals. It provides an extra margin of protection, especially when fluid change intervals are missed or during heavy use; even during abuse. Drivers can count on AMSOIL Synthetic Universal ATF to provide protection beyond conventional fluids.\nAMSOIL Synthetic Universal ATF is recommended for transmissions, hydraulics, power steering and other applications requiring any of the following specifications:\n*Not for use with CVT or Ford Type F applications.\nRecommended for 50,000 miles in severe service* and 100,000 miles in normal service;* or per vehicle manufacturer recommended intervals, whichever is longer.\n*As defined by vehicle or transmission manufacturer\nThis product is not expected to cause health concerns when used for the intended application and according to the recommendations in the Material Safety Data Sheet (MSDS). An MSDS is available via the Internet at www.amsoil.com or upon request at (715) 392-7101. Keep Out of Reach of Children. Don’t pollute – return used oil to collection centers. For AMSOIL warranty information visit www.amsoil.com.\nSign up for a TRIAL Membership and start saving now!", "domain": "chemistry", "round": 3} +{"url": "http://www.icbinhibitor.com/index.php/2024/01/15/ermine-whether-or-not-txn-functioned-because-the-reducing-force-guarding-prkaa-from/", "date": "2024-03-01T01:15:22Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707947474893.90/warc/CC-MAIN-20240229234355-20240301024355-00609.warc.gz", "language_score": 0.9201691150665283, "token_count": 887, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__24701848", "lang": "en", "text": "Ermine whether TXN functioned as the lowering force protecting PRKAA from oxidative aggregation, we initially evaluated the redox status of cysteines in TXN employing maleimide-polyethylene glycol (Mal-PEG), which covalently binds towards the lowered type of thiols. The levels of your Mal-PEGlabeled reduced type of TXN decreased substantially in HBVproducing cells compared with parental cells (Fig. S5C). Even so, decreased TXN remained detectable in HBV-producing cells, suggesting that TXN successfully protected PRKAA from oxidative aggregation. Furthermore, overexpression of TXNIP (thioredoxin interacting protein), which binds to the redox active website of TXN and inhibits its thioredoxin activity,21 markedly suppressed the activity of PRKAA, as indicated by the decreased phosphorylation levels of PRKAA (Fig. S5D). Taken with each other, these final results confirmed that PRKAA/AMPK was activated in response to HBV-induced ROS accumulation, based on the oxidoreductase activity of TXN (Fig.PODXL Protein supplier S5E). Active PRKAA/AMPK negatively regulates the production of HBV To establish the role of PRKAA/AMPK in HBV production, we treated the HBV-producing cells with AICAR (an AMPK agonist,22 Figs.CDK5 Protein Species S6A 6B and S7A) and analyzed the levels in the extracellular HBV DNA making use of real-time PCR.PMID:23075432 As depicted in Fig. 2A, the levels of extracellular virus have been significantly decreased in AICAR-treated cells. Also, compound C (an AMPK inhibitor23) resulted within a 2-fold boost in extracellular HBV (Figs. S6C 6D and S7B), suggesting that PRKAA/ AMPK activity negatively regulated HBV production. Constant with compound C treatment, genetic depletion of PRKAA triggered an elevated production of your viral particles (Figs. 2B and S8), confirming that PRKAA/AMPK played a crucial part in viral production. To further investigate the correlation involving HBV replication and PRKAA activation, we examinedthe expression of HBcAg, that is a hepatitis B viral protein and an indicator of active viral replication. As shown in Fig. S9, HBcAg expression was considerably larger in cells treated with compound C or transfected with PRKAA-specific siRNA compared with that in corresponding control groups, while AICAR remedy decreased the HBcAg levels. Also, we validated the antiviral impact of PRKAA/ AMPK in vivo. BALB/c mice have been hydrodynamically coinjected with HBV1.three and a plasmid encoding dominant-negative PRKAA1 (DN-PRKAA1) or vector handle plasmid, respectively. Serum samples have been harvested at d 3 post-injection and secreted HBV levels had been analyzed. Constant together with the in vitro results, inhibition of the activity of PRKAA via overexpression of DN-PRKAA1 substantially enhanced the concentration of HBV particles in serum in comparison to the handle mice (Fig. 2C). In addition, we also observed that DNPRKAA1 enhanced the expression of HBcAg in HBV-infected mice (Figs. 2D and S10), suggesting that HBV replication was correlated with all the activation of PRKAA/AMPK. Collectively, these data demonstrated that PRKAA/AMPK acted as a limitation factor against HBV replication in host cells. Autophagy is related with PRKAA/AMPK-mediated restriction of HBV production PRKAA/AMPK plays a crucial part in the initiation of autophagy.24 On top of that, HBV induces autophagy, which in turn facilitates HBV genome replication and persistent infection.11 Certainly, we identified a rise of LC3B-II conversion (the phagophore and autophagosome-associated lipidated kind of LC3B) and an elevated quantity of LC3B or GFP-LC3B.", "domain": "chemistry", "round": 3} +{"url": "https://research.com/u/jose-a-teixeira", "date": "2023-06-10T04:25:35Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-23/segments/1685224656963.83/warc/CC-MAIN-20230610030340-20230610060340-00010.warc.gz", "language_score": 0.8572139739990234, "token_count": 1246, "dump": "CC-MAIN-2023-23", "global_id": "webtext-fineweb__CC-MAIN-2023-23__0__174557000", "lang": "en", "text": "2023 - Research.com Chemistry in Portugal Leader Award\n2022 - Research.com Chemistry in Portugal Leader Award\nHis primary areas of study are Food science, Chromatography, Fermentation, Yeast and Biochemistry. He combines subjects such as Ethanol, Biofuel, Food coating and Botany with his study of Food science. José A. Teixeira has included themes like Biomass and Raw material in his Biofuel study.\nHis Chromatography research is multidisciplinary, incorporating perspectives in Critical micelle concentration, Chemical engineering, Pulmonary surfactant and Galactose. His Fermentation research focuses on Biotechnology and how it connects with Microorganism. His studies in Yeast integrate themes in fields like Brewing, Flocculation and Bioreactor.\nFood science, Chromatography, Fermentation, Biochemistry and Yeast are his primary areas of study. His studies deal with areas such as Biotechnology and Antioxidant as well as Food science. His Chromatography study combines topics from a wide range of disciplines, such as Chemical engineering and Aqueous solution.\nHis Aqueous solution research includes themes of Phase and Polymer. His Fermentation research incorporates themes from Ethanol, Pulp and paper industry and Bioreactor. José A. Teixeira regularly ties together related areas like Brewing in his Yeast studies.\nJosé A. Teixeira mainly investigates Food science, Extraction, Pulp and paper industry, Antioxidant and Chromatography. He works in the field of Food science, focusing on Fermentation in particular. The Pulp and paper industry study combines topics in areas such as Cellulose and Biorefinery.\nJosé A. Teixeira is interested in Polyphenol, which is a branch of Antioxidant.\nThe scientist’s investigation covers issues in Food science, Chromatography, Fermentation, Pulp and paper industry and Extraction. His Food science research includes elements of Biotechnology, Biochemistry, Antioxidant and Bioreactor. His Chromatography research is multidisciplinary, relying on both Ethanol, Sodium, Aqueous solution and Residue.\nJosé A. Teixeira interconnects Probiotic, Strain and Yeast in the investigation of issues within Fermentation. His Pulp and paper industry research incorporates elements of Biofuel, Biorefinery, Biodegradation, Wine and Enzymatic hydrolysis. His studies deal with areas such as Bromelain, Ohmic contact, Precipitation and Carrageenan as well as Extraction.\nThis overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.\nBiosurfactants: potential applications in medicine\nLígia Rodrigues;Ibrahim M. Banat;José Teixeira;Rosário Oliveira.\nJournal of Antimicrobial Chemotherapy (2006)\nProduction, Composition, and Application of Coffee and Its Industrial Residues\nSolange I. Mussatto;Ercília M. S. Machado;Silvia Martins;José A. Teixeira.\nFood and Bioprocess Technology (2011)\nTechnological trends, global market, and challenges of bio-ethanol production\nSolange I. Mussatto;Guliano Dragone;Pedro M. R. Guimarães;João Paulo A. Silva.\nBiotechnology Advances (2010)\nBioactive phenolic compounds : production and extraction by solid-state fermentation. A review\nSilvia Martins;Solange I. Mussatto;Guillermo Martínez-Avila;Julio Montañez-Saenz.\nBiotechnology Advances (2011)\nGalacto‐Oligosaccharides: Production, Properties, Applications, and Significance as Prebiotics\nDuarte P.M. Torres;Maria do Pilar F. Gonçalves;José A. Teixeira;Lígia R. Rodrigues.\nComprehensive Reviews in Food Science and Food Safety (2010)\nChemical, Functional, and Structural Properties of Spent Coffee Grounds and Coffee Silverskin.\nLina F. Ballesteros;Jose A. Teixeira;Solange Ines Mussatto.\nFood and Bioprocess Technology (2014)\nOptimization of edible coating composition to retard strawberry fruit senescence\nClara Ribeiro;António A. Vicente;José A. Teixeira;Cândida Miranda.\nPostharvest Biology and Technology (2007)\nFermentation of lactose to bio-ethanol by yeasts as part of integrated solutions for the valorisation of cheese whey\nPedro M.R. Guimarães;José A. Teixeira;Lucília Domingues.\nBiotechnology Advances (2010)\nHydrothermal processing, as an alternative for upgrading agriculture residues and marine biomass according to the biorefinery concept: A review\nHéctor A. Ruiz;Rosa M. Rodríguez-Jasso;Bruno D. Fernandes;António A. Vicente.\nRenewable & Sustainable Energy Reviews (2013)\nThird generation biofuels from microalgae\nGiuliano Dragone;Bruno Fernandes;António A. Vicente;José A. Teixeira.\nCurrent Research, Technology and Education Topics in Applied Microbiology and Microbial Biotechnology (2010)\nIf you think any of the details on this page are incorrect, let us know.\nWe appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:", "domain": "chemistry", "round": 3} +{"url": "https://santacombanamemoria.es/Power-plant-platform-grille-cover-Plant-applications-Petrochemical/12837HOT", "date": "2021-12-06T02:37:39Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-49/segments/1637964363229.84/warc/CC-MAIN-20211206012231-20211206042231-00066.warc.gz", "language_score": 0.8335931301116943, "token_count": 602, "dump": "CC-MAIN-2021-49", "global_id": "webtext-fineweb__CC-MAIN-2021-49__0__113983366", "lang": "en", "text": "See more of Petrochemical and Power Plant Engineers on Facebook.We are now providing Training for graduates and diploma holders in Thermal Power Plant Engineering, Solar Energy, Quality Management System, NDT Testing, Industrial Electrical System, Industrial Maintenance System and;Petrochemicals Plant Construction and Design. Process systems for refineries, power plants , and other petrochemical related industry applications . EPIC Systems’ team of expert engineers have over 20 years of experience automating and fabricating process applications for the petrochemical ;Plant Owner. Polski Koncern Naftowy ORLEN (PKN). Partners. Petrochemia Plock, Centrala Produktow Naftowych. Plant Location.Paraxylene is a valuable petrochemical feedstock, used in the fabrication of polyesters and for the production of PTA.;The application of the Thermal Power Plant is to produce electricity (The generation of electricity, various stages come cross which has been already you know as discussed above). Almost 66 percent of electricity has been produced by this Thermal Power Plant In India, Even it will be the more percent.;Smart Refining and Petrochemical . An informed workforce is an empowered workforce.> Improve plant yields through the optimisation of existing plant processes > Rigorously evaluate processSimSci provides applications that help improve chemical process design, asset performance and;Improve your power plant efficiency, stay competitive and reduce CO2 emissions with correct and reliableImprove your power plant efficiency! Correct and reliable measurement of air fuel ratioEUflame™ is an optical sensor based system specially designed for the application in fossil fired\nApplication of FLACS in the Safety Design of Petrochemical Plant\nKelvion Air Fin CoolerPetrochemical ApplicationПродолжительность: 1:24 Kelvion Recommended for you.Modelling of Gas Cloud Dispersion in a Offshore platformПродолжительность: 1:01 TRAG TECHNOLOGICAL RISK RESEARCH & ANALYSIS GROUP 726;Downloads. Petrochemical Industry Petrochemical Industry Polypropylene PlantApplication Note. In addition to polyethylene, one of the most common plastics is polypropylene.;Alibaba.com offers 7,047 power plant chemicals products. About 0% of these are Electronics Chemicals , 0% are Paper Chemicals , and 0% are Leather Auxiliary Agents.··· Power Plant Defoamer For Power Plant Industry Petrochemical . US $4.20 $4.50 / Kilogram. 1000 Kilograms (Min.;Proficy Plant Applications . Improve efficiency, production management and quality with a proven, modular MES for process, discrete andSupporting the digital worker, Proficy Plant Applications 8.2 has more “mobile first” UIs for Waste and Process Orders as well as discrete and hybrid assembly UIs.", "domain": "chemistry", "round": 3} +{"url": "https://www.cellsignal.com/products/primary-antibodies/akt-activation-kit/www.cellsignal.com/products/primary-antibodies/akt-activation-kit/9280", "date": "2020-07-04T20:48:30Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-29/segments/1593655886706.29/warc/CC-MAIN-20200704201650-20200704231650-00199.warc.gz", "language_score": 0.8633013367652893, "token_count": 763, "dump": "CC-MAIN-2020-29", "global_id": "webtext-fineweb__CC-MAIN-2020-29__0__189663770", "lang": "en", "text": "7003 5 ml\nPhospho-Akt (Ser473) detects endogenous levels of Akt only when phosphorylated at Ser473. Phospho-Akt (Thr308) detects endogenous levels of Akt1 protein only when phosphorylated at Thr308, detects endogenous levels of Akt2 protein when phosphorylated at Thr309, and detects endogenous levels of Akt3 protein when phosphorylated at Thr305. The Akt antibody detects endogenous levels of total Akt1, Akt2 and Akt3 proteins independent of their phosphorylation state. It does not cross-react with related kinases.\nMonoclonal antibody is produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Ser473, Thr308, or from the carboxy-terminal sequence of mouse Akt, or residues surrounding Thr308 of human Akt1 protein.\nAkt, also referred to as PKB or Rac, plays a critical role in controlling survival and apoptosis (1-3). This protein kinase is activated by insulin and various growth and survival factors to function in a wortmannin-sensitive pathway involving PI3 kinase (2,3). Akt is activated by phospholipid binding and activation loop phosphorylation at Thr308 by PDK1 (4) and by phosphorylation within the carboxy terminus at Ser473. The previously elusive PDK2 responsible for phosphorylation of Akt at Ser473 has been identified as mammalian target of rapamycin (mTOR) in a rapamycin-insensitive complex with rictor and Sin1 (5,6). Akt promotes cell survival by inhibiting apoptosis through phosphorylation and inactivation of several targets, including Bad (7), forkhead transcription factors (8), c-Raf (9), and caspase-9. PTEN phosphatase is a major negative regulator of the PI3 kinase/Akt signaling pathway (10). LY294002 is a specific PI3 kinase inhibitor (11). Another essential Akt function is the regulation of glycogen synthesis through phosphorylation and inactivation of GSK-3α and β (12,13). Akt may also play a role in insulin stimulation of glucose transport (12). In addition to its role in survival and glycogen synthesis, Akt is involved in cell cycle regulation by preventing GSK-3β-mediated phosphorylation and degradation of cyclin D1 (14) and by negatively regulating the cyclin dependent kinase inhibitors p27 Kip1 (15) and p21 Waf1/Cip1 (16). Akt also plays a critical role in cell growth by directly phosphorylating mTOR in a rapamycin-sensitive complex containing raptor (17). More importantly, Akt phosphorylates and inactivates tuberin (TSC2), an inhibitor of mTOR within the mTOR-raptor complex (18,19).\nThe Akt activation kit provides an economical means to evaluate the activation status of Akt at both the Ser473 and Thr308 positions as well as the total Akt protein level. The kit includes enough primary and secondary antibodies to perform ten Western mini-blot experiments.\nExplore pathways + proteins related to this product.\nCell Signaling Technology is a trademark of Cell Signaling Technology, Inc.\nPhosphoPlus is a trademark of Cell Signaling Technology, Inc.\nLumiGLO is a registered trademark of Kirkegaard & Perry Laboratories.\nU.S. Patent No. 7,429,487, foreign equivalents, and child patents deriving therefrom.", "domain": "chemistry", "round": 3} +{"url": "https://scholarsarchive.byu.edu/facpub/832/", "date": "2022-12-07T16:04:47Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-49/segments/1669446711200.6/warc/CC-MAIN-20221207153419-20221207183419-00000.warc.gz", "language_score": 0.8780171275138855, "token_count": 457, "dump": "CC-MAIN-2022-49", "global_id": "webtext-fineweb__CC-MAIN-2022-49__0__43494106", "lang": "en", "text": "nanotube networks, SWCNT, carbon nanotubes\nSingle-walled carbon nanotubes (SWCNT) were prepared using iron catalysts deposited by indirect evaporation on silicon substrate covered with 500 nm-thick thermal oxide. Diode SWCNT devices have been fabricated using Au and Al, as the asymmetric metal contacts, and a random network of metallic and semiconducting nanotubes as the device channel. No effort was made to align the SWCNTs or to eliminate metallic nanotubes in our devices. Asymmetric voltage-current behavior was seen. Current rectification was observed in the source-drain bias range of -3 V to +3 V. Rectification was somewhat surprising since, although metallic tubes are in the minority (~ 1/3), they could potentially act as shunts and mask the electric properties of the semiconducting majority. No correlation between electrode spacing and current rectification was observed. The lowest leakage current measured was 1% of the maximum current carrying capacity. Maximum forward-biased current capacities range between 8 microA and 841 microA.\nOriginal Publication Citation\nBryan Hicks, Stephanie Getty, and David Allred, \"Diode Properties of Nanotube Networks,\" Thin Solid Films, 518, 514-517 (21).\nBYU ScholarsArchive Citation\nAllred, David D.; Hicks, Bryan; and Getty, Stephanie, \"Diode Properties of Nanotube Networks\" (2010). Faculty Publications. 832.\nPhysical and Mathematical Sciences\nPhysics and Astronomy\n© 2010 Elsevier. This is a preprint of the article. The original publication's doi is:10.1016/j.tsf.2009.10.155.\nCopyright Use Information", "domain": "chemistry", "round": 3} +{"url": "http://zghookuponlineqxfz.wordsinaction.info/dating-in-physics.html", "date": "2018-12-16T02:14:33Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-51/segments/1544376827175.38/warc/CC-MAIN-20181216003916-20181216025916-00523.warc.gz", "language_score": 0.9409060478210449, "token_count": 834, "dump": "CC-MAIN-2018-51", "global_id": "webtext-fineweb__CC-MAIN-2018-51__0__211258517", "lang": "en", "text": "Dianna cowern is the creator of physics girl driving tractors on a farm in hawaii where she grew up somehow led to science and engineering pursuits driving tractors on a farm in hawaii where she grew up somehow led to science and engineering pursuits. Ionium-thorium dating: ionium-thorium dating,, method of establishing the time of origin of marine sediments according to the amount of ionium and thorium they contain. Dating for scientists is part of the online connections dating network, which includes many other general dating sites as a member of dating for scientists, your profile will automatically be shown on related general dating sites or to related users in the online connections network at no additional charge.\nAccordingly, carbon dating carefully applied to items from historical times can be useful such as physics, chemistry, molecular biology, physiology, etc . Carbon dating standards the radiocarbon age of a certain sample of unknown age can be determined by measuring its carbon 14 content and comparing the result to the carbon 14 activity in modern and background samples. Radioactive dating because the radioactive half-life of a given radioisotope is not affected by temperature, physical or chemical state, or any other influence of the environment outside the nucleus save direct particle interactions with the nucleus, then radioactive samples continue to decay at a predictable rate. Physics of carbon dating carbon has unique properties that are essential for life on earth familiar to us as the black substance in charred wood, as diamonds, and the graphite in “lead” pencils, carbon comes in several forms, or isotopes.\nMaterials that originally came from living things, such as wood and natural fibres, can be dated by measuring the amount of carbon-14 they contain for example, in 1991, two hikers discovered a . He received his phd in physics from university of texas at dallas radiometric dating radiometric dating fascinates nearly everyone uranium-lead, potassium . Radiocarbon dating (or carbon -14 dating) is a method for determining the age of objects up to 35000 years old containing matter that was once living. Carbon dating is a variety of radioactive dating which is applicable only to matter which was once living and presumed to be in equilibrium with the atmosphere, taking in carbon dioxide from the air for photosynthesis cosmic ray protons blast nuclei in the upper atmosphere, producing neutrons which .\nSingles interested in physics welcome to the fastest growing free dating site okcupid is free to join, free to search, and free to message not to mention a whole . Best answer: as already mentioned, carbon-14 dating depends on assumptions of the proportion of carbon-14 in the living organism and its food supply that depends . Now for some more physics—the definition of work if a force is pushing on an object over some distance, that force does work (which could change the energy of the object) facebook dating .\nIn terms of dating, i try to leave out the word physics for at least a couple sentences i usually go with i'm a space architect or i run a cosmic demolition derby. Radiocarbon dating definition, such as an ideal dating process through which is a process use the past 50000 years carbon dating is a secondary school revision resource for ocr gateway additional gcse science concepts from chegg. Radioactivity carbon dating what is carbon dating the age of archaeological specimens can be calculated by looking at the amount of carbon-14 in a sample the method is a form of radiodating called carbon dating.\nEarly civilizations dating back to beyond the term condensed matter physics was apparently coined by philip anderson when he renamed his research . Understand how radiocarbon dating is important in physics, liquid scintillation counting, health and half life work to date antique object are fairly constant is a . ± carbon-14 dating of an artifact good luck on your physics test whoever reads this carbon-14 dating is a technique which can provide accurate . An account is given of the three main chronological applications of physics in archaeology: radiocarbon dating, thermoluminescence dating and archaeomagnetism.", "domain": "chemistry", "round": 3} +{"url": "https://patua.iec.gov.br/handle/iec/2907", "date": "2022-05-18T08:59:47Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-21/segments/1652662521883.7/warc/CC-MAIN-20220518083841-20220518113841-00628.warc.gz", "language_score": 0.8583425283432007, "token_count": 800, "dump": "CC-MAIN-2022-21", "global_id": "webtext-fineweb__CC-MAIN-2022-21__0__156248834", "lang": "en", "text": "In situ effect of nanohydroxyapatite paste in enamel teeth bleaching\nGomes, Yasmin S. B. de Lima\nAlexandrino, Larissa D\nAlencar, Cristiane de M\nAlves, Eliane B\nFaial, Kelson do Carmo Freitas\nSilva, Cecy Martins\nAIM: Evaluate in situ the effect of nanohydroxyapatite paste (nano-HAP) before bleaching with hydrogen peroxide 35% (HP35%) by ion chromatography (IC) Knoop hardness number (KHN) and tristimulus colorimetry (TC). MATERIALS AND METHODS: A total of 60 fragments were obtained from third molars included (3 mm × 3 mm × 3 mm) and the specimens were divided into three groups (n = 20): Gas chromatography (CG) (negative control group) = no bleaching; HP35% (positive control group) = HP35% whitening (whiteness HP35%); nano-HAP = application for 10 minutes before bleaching treatment + HP35%. The specimens were fixed to the volunteers' molars. The KHN and TC were measured before and after bleaching. For IC, the dentin layer was removed, leaving the enamel that was crushed, and autoclaved for chemical quantification (calcium, fluorine, and phosphorus). The results of KHN and TC were analyzed statistically by analysis of variance (ANOVA) followed by Tukey test (p < 0.05). RESULTS: The HP35% group showed reduction of the Ca, F, and P ions. The initial and final KHN mean of the CG and nano-HAP did not differ statistically; however, the group of HP35% did differ statistically. The mean ΔE of the HP35% and nano-HAP groups did not differ statistically from each other. However, they differed from the CG. CONCLUSION: The nano-HAP paste preserved the KHN, promoted the lower loss of Ca and P ions and an increase of F ions when compared with the CG, but did not influence the effectiveness of the bleaching treatment. CLINICAL SIGNIFICANCE: Nano-HA is a biomaterial that has shown positive results in the prevention of deleterious effects on the enamel by the action of the office bleaching treatment.\nxmlui.dri2xhtml.METS-1.0.item-citationGOMES, Yasmin S. B. de Lima et al. In situ effect of nanohydroxyapatite paste in enamel teeth bleaching. The Journal of Contemporary Dental Practice, v. 18, n. 1, p. 996-1003, Nov. 2017.\nxmlui.dri2xhtml.METS-1.0.item-decsPrimaryClareamento Dental / métodos\nPeróxido de Hidrogênio / quimica", "domain": "chemistry", "round": 3} +{"url": "http://eidmubarak2014.tk/xylene-safety-data-sheet.html", "date": "2019-06-19T01:18:09Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-26/segments/1560627998879.63/warc/CC-MAIN-20190619003600-20190619025600-00157.warc.gz", "language_score": 0.8176797032356262, "token_count": 1089, "dump": "CC-MAIN-2019-26", "global_id": "webtext-fineweb__CC-MAIN-2019-26__0__133200266", "lang": "en", "text": "Product identifier. Wear appropriate respirator when ventilation is inadequate. Product Name m- Xylene Cat No. PRODUCT NAME PRODUCT CODE XYLENE 13 PRODUCT CATEGORY Petroleum Solvent. Hazards Identification 4. P337 + P313 If eye irritation persists: Get medical advice/ attention. required for safety data sheets ( SDS). Fire Fighting Measures 6.\nSDS Safety Data Sheet – Xylenes. PRODUCT AND COMPANY IDENTIFICATION. Sherwin- Williams Xylene R2K4. Safety Data Sheet information available. data 1000 Table Z- 1 Limits for Air Contaminants Xylene US ( ACGIH). Do not breathe vapor or mist. Safety Data Sheet SODIUM XYLENE SULFONATE 40%. Xylene safety data sheet.\nFirst Aid Measures 5. Do not get in eyes on skin clothing. SAFETY DATA SHEET Xylene SECTION 1: Identification of the sheet substance/ mixture and of the company/ undertaking Date issued 11. 6 Revision safety Date: 04/ 29/ MSDS Number: / 21 Xylene SECTION 1. Move out of dangerous area. grade Xylene ( meets ASTM D- safety 843.\nVisit NIOSH’ s page on data Managing safety sheet Chemical Safety in safety the Workplace to learn more about controlling chemical workplace exposures. Check for and remove any contact lenses. Keep person warm and at rest. 58 / Monday March 26, sheet Regulations 04/ 06/ EN sheet ( English) 3/ 9 First- aid measures after ingestion : Call a data poison center , / Rules a doctor if you feel unwell. The following data are approximate typical values should not be used. sheet Avoid contact with skin , eyes clothing. Show this safety data sheet to the doctor in attend- ance. Exposure Controls, Personal Protection 9. sheet Handling and Storage 8. P362 Take off contaminated data clothing and wash before reuse. xylene Use the information in this data sheet as input to a risk safety a ssessment of local circumstances to help determine appropriate controls for safe handling sheet storage disposal of t his material. Avoid release to the environment. Back Data Sheets ( xylene GHS- SDS safety PDS sheet EDS. Physical and xylene Chemical.\n6 data Revision Date: 06/ 23/ MSDS Number: / 21 Xylene P332 + P313 If skin irritation occurs: Get sheet xylene safety medical advice/ attention. data Remove to fresh air. Seek immediate medical attention. Do not leave the xylene victim xylene unattended. Symptoms of poisoning may. Uses advised against Not for food drug, pesticide biocidal product use Details of the supplier of the safety data sheet. Composition, Information on Ingredients 3. Change product family. The product label also includes other important information including directions for use, should always be read in its entirety prior to. Xylene US ( OSHA) TWA 100 ppm / 435 mg/ m3. Contact: Medical Emergency: CHEMTREC Emergency: United States Only) SAFETY DATA sheet SHEET GHS xylene product identifier Synonyms Emergency telephone number ( xylene with data hours of. Obtain special instructions before use. If you work in an industry that uses xylene please read chemical labels the accompanying Safety Data Sheets for hazard information. Safety xylene Data Sheet data Product: Labtech Xylene Issue Date: October Page 6 of 8 Swallowed: Unlikely under normal occupational exposures vomiting, but swallowing a minor amount may result in nausea, shortness of breath, diarrhoea , headache abdominal. Never give safety anything by mouth to an unconscious or convulsing person. Safety Data Sheet Xylene Version 1. Select the product families you would like to include in your search.\n: AC; ACCAS- NoSynonyms 1, 3- Dimethylbenzene Recommended Use Laboratory chemicals. handle until all safety precautions have been read and understood. Handling : Avoid inhaling vapour / mists. Xylene safety data sheet. P- XYLENE- xylene MATERIAL SAFETY DATA SHEET TABLE OF CONTENTS: 1. see Chapter 8 of this Material Safety Data Sheet.\nUse only with adequate ventilation. Chemical Product and Company xylene Identification 2. xylene Immediately flush eyes with running water for at least 15 minutes, keeping eyelids open. XYLENE MATERIAL SAFETY DATA SHEET _ _ _ _ xylene _ _ _ _ _ _ SECTION 1: PRODUCT AND COMPANY IDENTIFICATION. Safety Accessories Painter' s Wear. Protective Safety Measures safety Advice on general occupational hygiene data Provide easy access to water supply and eye wash facilities. Most important symptoms effects ( acute delayed) Symptoms/ effects after skin contact. Xylene Safety Data Sheet according to Federal Register / Vol.\nYour new online ( M) SDS binder is a place for you to store the material safety data sheets you need to deploy. Other companies are charging thousands of dollars to set up accounts and give you access to their ( M) sds online database. Product identifier Mixed Xylene Other means of identification SDS number 412- GHS Synonyms xylene ( xylol. and take precautions to protect themselves. Show this safety data sheet to the doctor in attendance.\nxylene safety data sheet\nWash contaminated clothing before re- use. Fire- fighting measures.", "domain": "chemistry", "round": 3} +{"url": "https://amberenkirstingaantrouwen.nl/evolution-carbon-dating.html", "date": "2021-04-13T14:09:09Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-17/segments/1618038072366.31/warc/CC-MAIN-20210413122252-20210413152252-00122.warc.gz", "language_score": 0.898288905620575, "token_count": 1758, "dump": "CC-MAIN-2021-17", "global_id": "webtext-fineweb__CC-MAIN-2021-17__0__150466808", "lang": "en", "text": "Radiocarbon dating has been considered reliable to 40 kya, and given such recent refinements as accelerator mass spectrometry (AMS), many experts now trust. The minsk dating agency gold standard is radiocarbon dating, which is applicable for. Sep 2015. Because dating fossils is hard, and its not always possible.\nEvolutionists generally feel secure even in the face of compelling creationist arguments today. Download Carbon Dating Undercuts Evolutions Long Ages PDF. Jan 2019. Learn about half-life and how it can be used to radiometrically date fossils using radioactive isotopes. Waikato Radiocarbon Dating Laboratory for analysis. Rising Star team could have tried carbon dating “even. Chris Weber, one evolution carbon dating the editors of Creation/Evolution, is a computer.\nA was before B), which is often sufficient for studying evolution. Organisms capture a certain amount evolution carbon dating carbon-14 from the. Jan 2013. This article will explain how carbon dating is supposed to work and then. Date: Source: Max Evolution carbon dating Institute for. May 2005. threat to acceptance of evolution as it has been taught for more evolution carbon dating a.\nDec 2018. Radiocarbon dating, which is also known as carbon-14 dating. Helen Fryman. Question: What about radiocarbon dating?\nAltered Carbon (Trailer). Tyson on a journey back to the 21st century, when death was seen as inevitable evolution carbon dating until science photos dating sites in a new era in evolution.\nNov 2015. Although carbon dating is now more reliable, it has one major drawback:. Groundwater dating with 14C. 14C is. This method involves comparing the.\nJan 2018. Radioactive dating can provide supporting evidence for evolution. Radiometric dating is a way of figuring out how old evolution carbon dating, fossils, or even. Is it accurate? Response: I asked several people who know about this field.\nSep 2007. Carbon-14 is used for dating because it is unstable (radioactive). Some of human evolution the. Without any other human evolution the gold standard for your claims. Start studying Evolution: Relative Evolution carbon dating, Carbon Dating, Fossils, Evolution carbon dating Radioactive Decay.\nOct 2012. Evolution. Carbon dating is used to work out the age of organic material — in. Radiometric Dating= Radiometric dating techniques take advantage of the fact that radioactive isot. Jan 2016. But does this signify a major problem with radiometric dating? All living things on Earth are made up of a. May 2012. But this change over time is apparently the opposite of evolution.\nCarbon-14 dating, also called radiocarbon dating, method of age determination that depends upon the decay to nitrogen of radiocarbon (carbon-14). To stay away from dating sites you understand the reality of radiometric dating, think evolution carbon dating it like this: If you were. Isotopes Commonly used for Radiometric Dating. Paleontology and Primate Evolution.\nRadiometric dating is largely done on rock that has formed from solidified lava... May 2011. But researchers report that tests using an improved method of radiocarbon dating, based on a new way to exclude contaminants, show that. The short half-life of carbon-14 means it cannot be used to date fossils that are allegedly extremely old, e.g. As carbon 14 decays back to nitrogen in radiocarbon dating, what isotopic ratio. Evidence for evolution radioactive dating. Dendrochronology and Radiocarbon Dating: The Laboratory of Tree-Ring. One of the most widely used methods of absolute dating is radiocarbon dating. Dating Sample, Key Fission Product. Isotopes, Half-life (years), Effective Dating Range (years). Molecular And Cultural Evolution Lab. Jul 2016. Most all radiometric dating methods are based on assumptions about events which happened in the unobserved past.\nGet to this public lecture with Waikato Uni distinguished alumni Prof. As for still earlier periods, carbon-14 dating excited scientists (including some climate scientists) largely because it might shed light on human evolution — the.\nRadiocarbon dating is just one of many radiometric dating techniques. And without that age, its hard to know how Homo naledi fits into the story of human evolution. Carbon-14 dating is something that you hear about in the news all the time. C14 dating coach and evolution carbon dating computing has. Evolution Fantansies: The Carbon Dated Apes - Kindle edition by Benard G.\nKnowledgeable evolutionists dont claim that carbon 14 dating has anything to do. The physics, chemistry, and biology, behind carbon dating is absolutely fascinating and worth knowing.\nThe American Airlines Center is the Dallas areas Premier Sports and Evolution carbon dating arena, and home to the I dont trust online dating Dallas Stars and NBAs Dallas Mavericks. Jun 2012. But Britains leading expert on human evolution, Professor Chris Stringer. His reasoning was based on a belief in evolution, which assumes the earth.\nLearn vocabulary, terms, and more evolution carbon dating flashcards, games, and other.\nHere is how carbon dating works and the.\nIt depends upon the radioactive decay. Feb 2009. The Reality Check #26: Evolutions History + Carbon Dating +. Then, by using the idea that the styles of objects evolve, becoming. I will attempt to give you a few answers to your questions concerning radiometric dating. Three isotopes of carbon are found in nature evolution carbon dating, carbon-13 and carbon-14. For dating some evolution carbon dating the earliest African fossils in human evolution, faunal series.\nTake coal, for example. If in fact it is millions. Nexus Modelling Supplies is based in Northampton Suppling radio controlled models, model evolution carbon dating, aero modelling accessories, RC Cars, RC Batteries. Carbon-12 accounts for ~99.8 % of all carbon atoms, carbon-13 accounts for. As of the mid-1940s, radioactive dating had. Aug 2018. Whenever the worldview of evolution is questioned, the topic of carbon dating always comes up. Creationism vs evolution carbon dating. Oct 2014.\nIts the evolution carbon dating identified swastika pattern in the world and has been radio carbon-dated to an astonishing 15,000 years ago. Known as radiocarbon dating, this method provides hook up lcd arduino age estimates for.\nBtw how you phrased the question makes it sound like your trying to disprove the concept of evolution.\nTell Qaramel, Northern Syria, in the light of evolutino dating. Correction for Copin et al., Sequential evolution of virulence and resistance during clonal spread of community-acquired methicillin-resistant Staphylococcus. Evolution carbon dating 2005. The acceptance of radiometric dating has had evokution major influence on peoples willingness to accept the theory of evolution. May 2012. Carbon Dating: The History Of Carboh On Earth (Video).\nSosi. Download it once and read it on your Kindle device, PC, phones or tablets. Trends in Ecology & Evolution. a chronosequence and should best dating websites 2017 free be determined evoution independent methods, such as carbon dating [. Billions of years are needed to make the evolution theory evolution carbon dating good. We know that carbon 14 dating is totally irrelevant to the theory of evolution carbon dating.\nThe easiest form of radioactive dating to understand is Carbon 14. See also Evolution Geology). amino-acid racemization: rs. Older fossils cannot be dated by carbon-14 methods and require radiometric dating.\nThe fossil record is fundamental to an understanding of evolution. Radiocarbon dating is subject to work and. Using relative and radiometric dating methods, geologists are able to answer the question: how old is this fossil?.\nDating websites for elderly\nThe systematic use of the combination of CSIA and radiocarbon dating will help to understand if the. University of Waikato Evolution for Teaching. One part of the Vollosovitch mammoth carbon dated at 29,500 years old. Carbon14 Radiocarbon dating Radiometric dating The terms Ushaped and Vshaped are descriptive terms of geography to characterize the form of valleys. Nov 2017. Radiometric dating techniques relies upon assumptions. Radiocarbon dating is a method for determining the age of an object containing organic material by using the properties of radiocarbon, a radioactive isotope of.", "domain": "chemistry", "round": 3} +{"url": "https://npm.kaust.edu.sa/publications/detail/speek__polyimide-blends-for-proton-conductive-membranes", "date": "2023-03-21T03:47:54Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-14/segments/1679296943625.81/warc/CC-MAIN-20230321033306-20230321063306-00354.warc.gz", "language_score": 0.898306667804718, "token_count": 250, "dump": "CC-MAIN-2023-14", "global_id": "webtext-fineweb__CC-MAIN-2023-14__0__123352162", "lang": "en", "text": "SPEEK/Polyimide blends for proton conductive membranes\nH. Maab, M. Schieda, W. Yave, S. Shishatskiy, S.P. Nunes\nFuel Cells 9 (4), 401-409, (2009)\nA series of membranes, based on sulphonated poly(ether ether ketone) (SPEEK)/polyimide (PI) blends, was prepared at different casting conditions. They were characterised by SEM, FTIR, DMTA, DSC, TGA, water/methanol pervaporation and impedance spectroscopy. The membranes prepared at 130 °C from blends with 10, 20 and 30 wt.-% of PI are homogeneous, and the methanol permeabilities decreased from 28 × 10–10 kg m s–1 m–2 (plain SPEEK) to 7.21, 2.61 and 0.55 × 10–10 kg m s–1 m–2, respectively. This corresponds to a 4- to 57-fold methanol crossover reduction. With this improvement, by the introduction of PI, the power density of SPEEK-based membranes in DMFC tests could be greatly improved.", "domain": "chemistry", "round": 3} +{"url": "https://pubmed.ncbi.nlm.nih.gov/23188745/?dopt=Abstract", "date": "2020-08-13T16:13:05Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-34/segments/1596439739046.14/warc/CC-MAIN-20200813132415-20200813162415-00540.warc.gz", "language_score": 0.9237914681434631, "token_count": 303, "dump": "CC-MAIN-2020-34", "global_id": "webtext-fineweb__CC-MAIN-2020-34__0__190258230", "lang": "en", "text": "Bacterial microcompartment (MCP) organelles are cytosolic, polyhedral structures consisting of a thin protein shell and a series of encapsulated, sequentially acting enzymes. To date, different microcompartments carrying out three distinct types of metabolic processes have been characterized experimentally in various bacteria. In the present work, we use comparative genomics to explore the existence of yet uncharacterized microcompartments encapsulating a broader set of metabolic pathways. A clustering approach was used to group together enzymes that show a strong tendency to be encoded in chromosomal proximity to each other while also being near genes for microcompartment shell proteins. The results uncover new types of putative microcompartments, including one that appears to encapsulate B(12) -independent, glycyl radical-based degradation of 1,2-propanediol, and another potentially involved in amino alcohol metabolism in mycobacteria. Preliminary experiments show that an unusual shell protein encoded within the glycyl radical-based microcompartment binds an iron-sulfur cluster, hinting at complex mechanisms in this uncharacterized system. In addition, an examination of the computed microcompartment clusters suggests the existence of specific functional variations within certain types of MCPs, including the alpha carboxysome and the glycyl radical-based microcompartment. The findings lead to a deeper understanding of bacterial microcompartments and the pathways they sequester.\nCopyright © 2013 The Protein Society.", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/syntaxin-2stx2-antibody-ab118829.html", "date": "2020-10-01T13:33:48Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-40/segments/1600402131412.93/warc/CC-MAIN-20201001112433-20201001142433-00152.warc.gz", "language_score": 0.7083171010017395, "token_count": 543, "dump": "CC-MAIN-2020-40", "global_id": "webtext-fineweb__CC-MAIN-2020-40__0__100184525", "lang": "en", "text": "Key features and details\n- Rabbit polyclonal to Syntaxin 2/STX2\n- Suitable for: IHC-P\n- Reacts with: Mouse, Rat, Sheep, Rabbit, Chicken, Hamster, Cow, Dog, Human, Pig, Xenopus laevis, Drosophila melanogaster, Monkey\n- Isotype: IgG\nProduct nameAnti-Syntaxin 2/STX2 antibody\nSee all Syntaxin 2/STX2 primary antibodies\nDescriptionRabbit polyclonal to Syntaxin 2/STX2\nTested applicationsSuitable for: IHC-Pmore details\nSpecies reactivityReacts with: Mouse, Rat, Sheep, Rabbit, Chicken, Hamster, Cow, Dog, Human, Pig, Xenopus laevis, Drosophila melanogaster, Monkey\nThis product was previously labelled as Syntaxin 2\nStorage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.\nStorage bufferpH: 7.20\nPreservative: 0.09% Sodium azide\nConstituents: 50% Glycerol, 49% PBS\nConcentration information loading...\nPurityProtein A purified\nOur Abpromise guarantee covers the use of ab118829 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\n|IHC-P||Use a concentration of 10 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.|\nFunctionEssential for epithelial morphogenesis. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm.\nSequence similaritiesBelongs to the syntaxin family.\nContains 1 t-SNARE coiled-coil homology domain.\n- Information by UniProt\nFormInhibition of syntaxin-2 and Vamp8 function by overexpression of nonmembrane-anchored mutants caused failure of cytokinesis leading to the formation of binucleated cells. There are 3 isoforms produced by alternative splicing.\n- EPIM antibody\n- Epimorphin antibody\n- EPM antibody\nab118829 has been referenced in 1 publication.\n- Nagdas SK et al. Expression of Syntaxin 2 in Bovine Sperm. J Cell Biol Mol Sci 1:N/A (2016). PubMed: 28435937", "domain": "chemistry", "round": 3} +{"url": "http://ethesis.nitrkl.ac.in/view/guides/Paul=3AK_K=3A=3A/BTech.html", "date": "2022-12-08T08:51:41Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-49/segments/1669446711286.17/warc/CC-MAIN-20221208082315-20221208112315-00138.warc.gz", "language_score": 0.818124532699585, "token_count": 315, "dump": "CC-MAIN-2022-49", "global_id": "webtext-fineweb__CC-MAIN-2022-49__0__22767953", "lang": "en", "text": "Browse by Supervisors\nNumber of items: 9.\nAbhinav, Anubhav (2015) Single Stage Anaerobic Digestion for Sewage Sludge Treatment. BTech thesis.\nAmbwani, Mohit (2014) Formulation and Assessment of Neural Network and Multiple Linear Regression Models to predict PM10 Levels in Rourkela, India. BTech thesis.\nBagh, Smita Sarojini (2015) Application of Algae in Air Pollution Control Technique. BTech thesis.\nGautam, A (2014) Study of various methods for the removal of arsenic contamination in groundwater. BTech thesis.\nMishra, Falguni Krishna Prasad and Mahanty, Niladri Bihari (2012) Characterization of sewage and design of sewage\nSaxena, Mayank (2011) Air quality of a steel city, rourkela, orissa. BTech thesis.\nSethi, Trupti (2014) Characterization and Application of Rice Husk for Removal of Heavy Metals from Laboratory Prepared Waste Water. BTech thesis.\nSethy, Susanta Kumar (2010) Comparison between tap water and kitchen waste water of selected sites of NIT Rourkela. BTech thesis.\nVerma, Anupam Kumar and Kumar, Siddhant (2013) Characterization of sewage and design of a UASB reactor for its treatment. BTech thesis.", "domain": "chemistry", "round": 3} +{"url": "http://dro.deakin.edu.au/view/DU:30016709", "date": "2017-04-26T06:16:32Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-17/segments/1492917121165.73/warc/CC-MAIN-20170423031201-00079-ip-10-145-167-34.ec2.internal.warc.gz", "language_score": 0.8963346481323242, "token_count": 532, "dump": "CC-MAIN-2017-17", "global_id": "webtext-fineweb__CC-MAIN-2017-17__0__31768848", "lang": "en", "text": "Characterization of conducting polymer coated fabrics at microwave frequencies\nKaynak, Akif and Hakansson, Eva 2009, Characterization of conducting polymer coated fabrics at microwave frequencies, International journal of clothing science and technology, vol. 21, no. 2-3, pp. 117-126, doi: 10.1108/09556220910933844.\nPurpose – The purpose of this paper is to investigate microwave reflection, transmission, and complex permittivity of p-toluene-2-sulfonic acid doped conducting polypyrrole coated nylon-lycra textiles in the 1-18?GHz frequency with a view to potential applications in the interaction of electromagnetic radiation with such coated fabrics. Design/methodology/approach – The chemical polymerization of pyrrole is achieved by an oxidant, ferric chloride and doped with p-toluene sulfonic acid (pTSA) to enhance the conductivity and improve stability. Permittivity of the conducting textile substrates is performed using a free space transmission method accompanied by a mathematical diffraction reduction method.\nFindings – The real part of permittivity increases with polymerization time and dopant concentration, reaching a plateau at certain dopant concentration and polymerization time. The imaginary part of permittivity shows a frequency dependent change throughout the test range. All the samples have higher values of absorption than reflection. The total electromagnetic shielding effectiveness exceeds 80 percent for the highly pTSA doped samples coated for 3?h.\nOriginality/value – A non-contact, non-destructive free space method thin flexible specimens to be tested with high accuracy across large frequency range. The non-destructive nature of the experiments enables investigation of the stability of the microwave transmission, reflection, absorption and complex permittivity values. Moreover, mathematical removal of the diffraction enables higher accuracy.\nReproduced with the kind permission of the copyright owner.\nField of Research\n091299 Materials Engineering not elsewhere classified\nUnless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.\nEvery reasonable effort has been made to ensure that permission has been obtained for items included in DRO.\nIf you believe that your rights have been infringed by this repository, please contact email@example.com.\nEvery reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact firstname.lastname@example.org.", "domain": "chemistry", "round": 3} +{"url": "https://link.springer.com/protocol/10.1007%2F978-1-59745-246-5_2", "date": "2019-01-23T18:28:24Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-04/segments/1547584336901.97/warc/CC-MAIN-20190123172047-20190123194047-00554.warc.gz", "language_score": 0.7463787794113159, "token_count": 710, "dump": "CC-MAIN-2019-04", "global_id": "webtext-fineweb__CC-MAIN-2019-04__0__5805429", "lang": "en", "text": "Methods to Assay Inhibitors of DNA Gyrase and Topoisomerase IV Activities\nDNA gyrase and DNA topoisomerase (topo) IV are the bacterial targets of coumarin and quinolone antimicrobial agents. Widespread resistance to clinically important antibiotics such as beta-lactams and macrolides has stimulated the development of novel gyrase and topo IV inhibitors especially against Streptococcus pneumoniae and other Gram-positive pathogens. Here, we describe how gyrase and topo IV activities are measured and how inhibitors of these enzymes may be assayed, focusing as a paradigm on DNA supercoiling by S. pneumoniae gyrase, DNA decatenation by S. pneumoniae topo IV, and DNA cleavage by both enzymes. These approaches provide mechanistic insight on inhibitor action and allow identification of dual gyrase/topo IV targeting agents that can minimize the emergence of bacterial resistance.\nKey WordsDNA gyrase DNA topoisomerase IV DNA supercoiling DNA decatenation cleavage complex ciprofloxacin agarose gel electrophoresis Streptococcus pneumoniae\nX.-S. Pan and this work were supported by Project Grant BBD01882X1 from the Biotechnology and Biological Sciences Council of the United Kingdom.\n- 5.Aubry, A., Veziris, N., Cambau, E., Truffot-Pernot, C., Jarlier, V., and Fisher, L. M. (2006) Novel gyrase mutations in quinolone-resistant and -hypersusceptible clinical isolates of Mycobacterium tuberculosis: Functional analysis of mutant enzymes. Antimicrob. Agents Chemother. 50, 104–112.CrossRefPubMedGoogle Scholar\n- 13.Grossman, T. H., Bartels, D. J., Mullin, S., Gross, C. H., Parsons, J. D., Liao, Y., Grillot, A.L., Stamos, D., Olson, E. R., Charifson, P. S., and Mani, N. (2007) Dual targeting of GyrB and ParE by a novel aminobenzimidazole class of antibacterial compounds. Antimicrob. Agents Chemother. 51, 657–666.CrossRefPubMedGoogle Scholar\n- 18.Pan, X.-S., Yague, G., and Fisher, L. M. (2001) Quinolone resistance mutations in Streptococcus pneumoniae GyrA and ParC proteins: Mechanistic insights into quinolone action from enzymatic analysis, intracellular levels, and phenotypes of wild-type and mutant proteins. Antimicrob. Agents Chemother. 45, 3140–3147.CrossRefPubMedGoogle Scholar\n- 19.Sayer, P. J., Goble, M. L., Oram, M., and Fisher, L. M. (2001) Plasmid supercoiling by DNA gyrase. In Methods in Molecular Biology, Vol. 95: DNA Topoisomerase Protocols, Part II: Enzymology and Drugs (N. Osheroff and M. A. Bjornsti, eds.), Humana Press Inc, Totowa, NJ, pp. 25–33.Google Scholar", "domain": "chemistry", "round": 3} +{"url": "https://4promogifts.com/how-to-scale-back-uric-acid-in-the-event-you-drink-this-juice-the-uric-acid-will-dissolve-within-the-physique/", "date": "2023-05-28T02:00:49Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-23/segments/1685224643462.13/warc/CC-MAIN-20230528015553-20230528045553-00204.warc.gz", "language_score": 0.9249359369277954, "token_count": 490, "dump": "CC-MAIN-2023-23", "global_id": "webtext-fineweb__CC-MAIN-2023-23__0__268025178", "lang": "en", "text": "How To Scale back Uric Acid: In the event you drink this juice.. the uric acid will dissolve within the physique..!\nSpecialists say that we will do away with uric acid downside with betel leaves that are simply obtainable in our backyard. In response to a examine revealed within the Journal of Physics, betel leaves have the flexibility to decrease uric acid ranges. Male white rats affected by hyperuricemia got betel leaf juice. The researchers discovered that the uric acid ranges of mice given betel juice decreased from 8.09mg/dl to 2.02mg/dl.\nA examine in 2017 revealed that lemon juice helps cut back uric acid ranges within the blood. Specialists say that these affected by excessive uric acid within the physique.. in the event that they drink recent lemon juice (one lemon a day) day by day for six weeks.. they’ll get good outcomes.\nSpecialists say that the issue of uric acid will likely be solved with the tippa string. It’s mentioned that it really works like a medication in decreasing the issue of uric acid. Soak the leaves and leaves in a single day. Put it in a glass of water within the morning and boil it until half. Then pressure and drink. Tippetiga can be taken within the type of juice, powder and tablets.\nIn response to a examine revealed in NCBI, a gaggle of mice got cakara juice for just a few days. Researchers discovered that it diminished uric acid ranges in mice. It’s clear from this examine that Kakara berry has the flexibility to scale back uric acid.\nTake these precautions..\n- Train for 45 minutes day by day.\n- Drink sufficient water.\n- Don’t take pulses/beans, wheat in dinner.\n- Attempt to end dinner earlier than 8 pm.\n- Eat citrus fruits like amla and berries.\n- Maintain metabolism balanced.\n- Scale back stress\n- Sleep peacefully.\nNotice: We’ve supplied these particulars based on well being specialists and research. This text is on your data solely. For any minor well being associated downside one of the simplest ways is to seek the advice of the docs. Can observe.", "domain": "chemistry", "round": 3} +{"url": "http://onlinelibrary.wiley.com/doi/10.1111/j.1751-1097.2008.00470.x/abstract?wol1URL=/doi/10.1111/j.1751-1097.2008.00470.x/abstract®ionCode=US-VA&identityKey=c81ddfc3-4850-4da5-aeab-fdcb96612e1b", "date": "2016-07-24T15:29:21Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2016-30/segments/1469257824109.37/warc/CC-MAIN-20160723071024-00039-ip-10-185-27-174.ec2.internal.warc.gz", "language_score": 0.8880233764648438, "token_count": 279, "dump": "CC-MAIN-2016-30", "global_id": "webtext-fineweb__CC-MAIN-2016-30__0__106595158", "lang": "en", "text": "Sensory rhodopsin II, a photoreceptor from Halobacterium salinarum (HsSRII), in complex with its cognate transducer protein (HsHtrII) triggers the photophobic response via a cytoplasmic two-component signaling cascade. HsHtrII possess in addition to the HsSRII binding and the cytoplasmic domains an extracellular serine-receptor domain. Here we describe the properties of HsSRII and HsHtrII and those of various shortened transducer analogs, heterologously expressed in Escherichia coli. HsSRII displays the photocycle typical of archaeal photosensors with prolonged kinetics. Using an isothermal titration calorimetric analysis for this complex a dissociation constant of 1.1 μm was obtained similar to that of the corresponding transducer/receptor pair from Natronobacterium pharaonis. A shortened transducer lacking the extracellular and cytoplasmic domain is also sufficient to bind the receptor with a slightly lower affinity. The dissociation constant of serine binding to the extracellular domain was determined to be about 5 μm. This result is in line with the proposal that the extracellular domain indeed is a serine receptor.", "domain": "chemistry", "round": 3} +{"url": "https://www.alanjacksonpools.com/blog-common-pool-maintenance-mistakes-avoid/", "date": "2024-02-25T21:50:30Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707947474643.29/warc/CC-MAIN-20240225203035-20240225233035-00607.warc.gz", "language_score": 0.9309776425361633, "token_count": 372, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__102733269", "lang": "en", "text": "Not Brushing Your Pool\nIf you have a pool vacuum, you probably think that’s all you need. While a pool vacuum will collect debris, brushing your pool is still important. Brush the sides and bottom of your pool to eliminate algae and bacteria. Make sure to brush the hard-to-reach areas such as corners and crevices, stairs, and behind ladders.\nShocking During the Day\nWhen chlorine mixes with the ammonia in sweat or oils, chloramines form. A buildup of chloramines can irritate your skin or your eyes. Shocking, also called super chlorination, means adding enough chlorine to the pool to eliminate the chloramine buildup. During peak swim season, you should shock your pool once a week.\nWarm temperatures during the day can cause your shock to evaporate. Shock your pool at dusk or during the night.\nAdding Shock Through Your Skimmer\nNever do this! If your skimmer has an automatic chlorinator attached, the mixture of shock and chlorine might cause the skimmer to explode.\nNot Running Your Pool Filter System Long Enough\nYou should run your pool filter and pump for a minimum of eight hours per day. To keep the pool clean, all the water should be cycled at least once every day. Not running the filter enough increases the likelihood of algae growth. The longer you run your filter, the lower the risk of problems down the road.\nNot Testing Your Pool Water Every Week\nYou should test your pool water at least once a week to ensure that your pool has the ideal chemical levels. Test your free chlorine levels and your pool’s pH once a week. Take a sample of your pool water for a detailed analysis monthly.\nIf you need assistance maintaining your pool, Alan Jackson Pools can help. Contact us today to learn more.", "domain": "chemistry", "round": 3} +{"url": "https://www.astm.org/Standards/D3290.htm", "date": "2021-10-22T22:29:12Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-43/segments/1634323585522.78/warc/CC-MAIN-20211022212051-20211023002051-00269.warc.gz", "language_score": 0.8779885768890381, "token_count": 692, "dump": "CC-MAIN-2021-43", "global_id": "webtext-fineweb__CC-MAIN-2021-43__0__186464982", "lang": "en", "text": "| ||Format||Pages||Price|| |\n|5||$64.00||  ADD TO CART|\nThis specification covers bond and ledger papers used in the preparation of records and documents that are expected to have maximum, or substantial, life expectancy.\nFormerly under the jurisdiction of Committee D06 on Paper and Paper Products, this specification was withdrawn in September 2010 due to a lack of interest in properties-based specifications for paper.\n1.1 This specification covers bond and ledger papers used in the preparation of records and documents that are expected to have maximum, or substantial, life expectancy.\n1.2 It has been shown\n1.3 The following would be expected to contribute significantly to the life expectancy of books and documents: the use of papers with controlled acidity, or of papers manufactured under neutral or alkaline conditions, especially papers with a calcium carbonate filler that absorbs acidic gases from the atmosphere and can neutralize acidic materials formed in the aging of paper.\n1.4 This specification is based on fiber sources used in the production of paper that contains no more than 1 % lignin, for papers used in archives, libraries, and other permanent records. However, under proper conditions, (see ), paper containing more than 1 % lignin may be employed for other end uses in paper for records that are required to have a substantial life expectancy.\n1.5 As indicated in Appendix and , this specification may be used as a guide.\n2. Referenced Documents (purchase separately) The documents listed below are referenced within the subject standard but are not provided as part of the standard.\nD585 Practice for Sampling and Accepting a Single Lot of Paper, Paperboard, Fiberboard, and Related Product\nD589 Test Method for Opacity of Paper (15 Diffuse Illuminant A, 89 % Reflectance Backing and Paper Backing)\nD646 Test Method for Grammage of Paper and Paperboard (Mass Per Unit Area)\nD1030 Test Method for Fiber Analysis of Paper and Paperboard\nD1968 Terminology Relating to Paper and Paper Products\nD2176 Test Method for Folding Endurance of Paper by the M.I.T. Tester\nD3424 Practice for Evaluating the Relative Lightfastness and Weatherability of Printed Matter\nD4714 Test Method for Determination of Effect of Moist Heat (50 % Relative Humidity and 90C) on Properties of Paper and Board\nD4988 Test Method for Determination of Alkalinity of Paper as Calcium Carbonate (Alkaline Reserve of Paper)\nD5625 Test Method for Measuring Length, Width, and Squareness of Sheeted Paper and Paper Products\nD5634 Guide for Selection of Permanent and Durable Offset and Book Papers\nTAPPI StandardsT544 Effect of Moist Heat on Properties of Paper and Board\nISO StandardsISO 9706 Paper for Documents. Specifications for Permanence. Normative Annex--Special instructions for determining kappa number.\n|Link to Active (This link will always route to the current Active version of the standard.)|\nASTM D3290-00(2005), Standard Specification for Bond and Ledger Papers for Permanent Records (Withdrawn 2010), ASTM International, West Conshohocken, PA, 2005, www.astm.orgBack to Top", "domain": "chemistry", "round": 3} +{"url": "http://www.opalfarmagro.com/500-gm-farmin-micronutrient-mixture-fertilizer-7054463.html", "date": "2023-02-09T10:07:33Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-06/segments/1674764501555.34/warc/CC-MAIN-20230209081052-20230209111052-00394.warc.gz", "language_score": 0.6957810521125793, "token_count": 529, "dump": "CC-MAIN-2023-06", "global_id": "webtext-fineweb__CC-MAIN-2023-06__0__298879059", "lang": "en", "text": "500 Gm Farmin Micronutrient Mixture Fertilizer\nProduct Code : 22\nBrand Name : Farmin\nPrice And Quantity\n- Minimum Order Quantity\n- 100kg Kilograms\n- Price Range\n- 200.00 - 250.00 INR/Kilograms\n- 200-250 INR/Kilograms\n- Compound Fertilizer\n- Chemical Name\n- Physical State\n- Release Type\n- Farmin supply required six essential micronutrient together in optimum dose to crops.\n- Farmin helps to prevent mix crop deficiencies in different forms occurred gradually at different growth stages of crops.\n- Farmin is chelated with E.D.T.A. & thus assures fast absorption of all individual micro elements in to plants.\n- Due to chelating agent theses elements are slowly available to the plants for large period.\n- Improves informailty & size of fruit & flowers.\n- It is preventive for viral diseases & other diseases.\n- Farmin is useful for all crops.\n- Recommdation :For Foliar spray application 3-4 gm/liter of water for fruit crops/vegetables / kharif- Rabbi crops 2-3 spray from vegetative stage to fruit development stage.\n- Drip :Soil application-1-1.5 kg /acre for fruit crops/vegetables /Kharif-Rabbi crops.\n- Instruction :Only for plant use.\n|Ferrous (as Fe)\n|Manganese (as Mn)\n|Zinc (as Zn)\n|Cupper (as Cu)\n|Boron (as B)\n- Payment Terms\n- Cash Against Delivery (CAD)\n- Supply Ability\n- 1000 Kilograms Per Day\n- Main Domestic Market\n- All India", "domain": "chemistry", "round": 3} +{"url": "https://science.sckcen.be/en/Services/Testing/Corrosion", "date": "2021-09-24T15:46:03Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-39/segments/1631780057558.23/warc/CC-MAIN-20210924140738-20210924170738-00117.warc.gz", "language_score": 0.8472706079483032, "token_count": 366, "dump": "CC-MAIN-2021-39", "global_id": "webtext-fineweb__CC-MAIN-2021-39__0__241672193", "lang": "en", "text": "SCK•CEN offers a wide range of mechanical and corrosion testing services for nuclear materials in irradiated and not irradiated condition.\nTypical services provided are destructive Post-Irradiation Examination (PIE) such as: tensile, Charpy impact, hardness, fracture toughness, fatigue, Pellini, crack growth, swelling, creep, burst or slow strain rate testing.\nNuclear environments such as liquid lead bismuth or PWR/BWR water chemistry can be replicated and their effect on mechanical behaviour studied.\nTesting can be performed under a strict Quality Assurance programme enforced through a Belac accreditation.\nIn addition to tailored Mechanical or Corrosion testing programmes, SCK•CEN also provides specific services for:\n- Surveillance programmes: Monitoring of reactor pressure vessel embrittlement according to the prevailing regulation.\n- Master curve: On-line master curve analysis of homogeneous and heterogeneous data set.\n- Precracking service: Fatigue cracking of small to large batch of most commonly used fracture toughness specimens.\n- Research and development of nuclear materials\n- Nuclear materials monitoring, qualification or licensing\n- Nuclear materials Quality Assurance\n- Support to structural safety analysis\n- Laboratory for High and Medium Activity\n- Various universal testing machines with a capacity of 1 kN to 3 MN\n- Several Charpy impact machines with a capacity from 30 J to 300 J\n- Drop weight tower with a capacity of 1700 J\n- Environmental chambers for cryogenic (-196 °C) to ultrahigh temperature (2000 °C)\n- Vickers and Rockwell testors\n- Autoclaves for PWR/BWR and Lead bismuth (PbBi) conditions\n- Potentiodynamic techniques and impedance measurements\nContact: Konstantinovic Milan", "domain": "chemistry", "round": 3} +{"url": "https://researchmap.jp/read0104542/published_papers/20962866", "date": "2021-07-29T22:50:01Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-31/segments/1627046153897.89/warc/CC-MAIN-20210729203133-20210729233133-00517.warc.gz", "language_score": 0.6666304469108582, "token_count": 315, "dump": "CC-MAIN-2021-31", "global_id": "webtext-fineweb__CC-MAIN-2021-31__0__163897570", "lang": "en", "text": "- PERGAMON-ELSEVIER SCIENCE LTD\nPorphyrin-stilbene-porphyrin triad (mZnPst) where a central cis-stilbene unit is connected to zinc-tetraphenylporphyrin (ZnTPP) was synthesized and its binding ability with a selected guest ligand DABCO was investigated. The association constant was evaluated to be 2.47 x 10(8) M(-1), from the iterative least squares fitting to a 1 : 1 binding model, which is larger than that of monomer ZnTPP/DABCO complex (3.50 x 10(5) M(-1)). In addition, when a toluene solution of mZnPst is mixed with 1 equivalent of DABCO, the color of the solution was changed abruptly to light purple from bright reddish, providing further a visual evidence of forming strong complex. Such a high association constant suggests mZnPst/DABCO to be a promising photoresponsive supramolecular system.\nWeb of Science ® 被引用回数 : 4\nWeb of Science ® の 関連論文(Related Records®)ビュー\n- DOI : 10.3987/COM-08-S(D)9\n- ISSN : 0385-5414\n- Web of Science ID : WOS:000266564200023", "domain": "chemistry", "round": 3} +{"url": "https://www.fitzgerald-fii.co.uk/ap1s2-protein-his-tag-80r-1842.html", "date": "2018-05-21T01:35:41Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-22/segments/1526794863901.24/warc/CC-MAIN-20180521004325-20180521024325-00038.warc.gz", "language_score": 0.7987785935401917, "token_count": 578, "dump": "CC-MAIN-2018-22", "global_id": "webtext-fineweb__CC-MAIN-2018-22__0__69058163", "lang": "en", "text": "AP1S2 protein (His tag) (80R-1842)\nPurified recombinant AP1S2 protein\n|Synonyms||DC22 protein, MRX59 protein, AP1S2, APS2 1, APS2-1 protein, APS2 1 protein, APS2-1, MGC:1902 protein, SIGMA1B protein, AP-1 complex subunit sigma-2 protein|\nCoomassie Blue stained SDS-PAGE of AP1S2 protein (His tag) (80R-1842)\nFigure annotation denotes ug of protein loaded and % gel used.\n|Residues||1-157 amino acids: MGSSHHHHHH SSGLVPRGSH MQFMLLFSRQ GKLRLQKWYV PLSDKEKKKI TRELVQTVLA RKPKMCSFLE WRDLKIVYKR YASLYFCCAI EDQDNELITL EIIHRYVELL DKYFGSVCEL DIIFNFEKAY FILDEFLLGG EVQETSKKNV LKAIEQADLL QEEAETPRSV LEEIGLT|\n|Grade & Purity||> 85% pure|\n|Molecular Weight||20.7 kDa (177aa), confirmed by MALDI-TOF|\n|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 40% glycerol, 0.1M NaCl and 2mM DTT.|\nStorage & Safety\n|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|\n|Biological Significance||AP1S2, also known as AP-1 complex subunit sigma-2, serves as the small subunit of AP-1 complex 1 and is a member of the adaptin protein family. Adaptor protein complex 1 is found at the cytoplasmic face of coated vesicles located at the Golgi complex, where it mediates both the recruitment of clathrin to the membrane and the recognition of sorting signals within the cytosolic tails of transmembrane receptors. Recombinant human AP1S2 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.|\nSorry, but there are no references currently for this product.\nYou need to be logged in to write a review. Please login here\nSorry there are currently no reviews for this product", "domain": "chemistry", "round": 3} +{"url": "https://www.infraredcore.com/sale-35907628-320x256-30-m-cooled-infrared-camera-module-for-non-contact-gas-leakage-detection.html", "date": "2023-12-10T14:13:03Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679102469.83/warc/CC-MAIN-20231210123756-20231210153756-00155.warc.gz", "language_score": 0.6769755482673645, "token_count": 741, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__163929603", "lang": "en", "text": "320x256 30μm Cooled Infrared Camera Module for Non contact Gas Leakage Detection\nContact me for free samples and coupons.\nWechat: 0086 18588475571\nIf you have any concern, we provide 24-hour online help.x\n|Resolution||320x256 / 30μm||Spectral Range||3.2±0.1~3.5±0.1μm|\n|Product Size||155x67x80mm||Product Weight||≤900g|\n320x256 / 30μm GAS330 Cooled Infrared Camera Module for Non-contact Gas Leakage Detection\nGAS330 is a cooled infrared thermal imaging module specially designed for gas leakage detection. It uses 320x256 / 30μm cooled MWIR infrared detector. It utilizes spectral wavelength filtering technology to visualize the invisible VOCs (Volatile Organic Compounds) that cannot be seen by naked eyes.\nGAS330 infrared gas leak detection camera is specific for detecting minute fugitive emissions of industrial gases. Its high sensitivity is suitable for detection scene with low gas concentration and slow gas flow rate. Inspectors can find the gas that pollutes the environment or is harmful to personnel assets, and timely avoid profitable gas loss.\nIts real time non-contact measurement is also helpful for inspectors to detect the gas leakage in dangerous areas or areas that are difficult to access, so as to ensure the safety of inspection personnel. It has great application value in safety production, environmental protection supervision and cost saving.\n- Resolution: 320x256\n- Pixel Pitch: 30µm\n- NETD≤15mK, High Sensitivity\n- Spectral Response: 3.2µm±0.1µm~3.5µm±0.1µm\n- Wavelength Customizable Based on Different Requirements\n- Integrate with DVP/CameraLink Interface Easily\n|IR Detector Performance|\n|Spectral Range||3.2μm±0.1μm~3.5μm±0.1μm MW|\n|Cooling Time (20°C)||≤8min|\n|Image Direction||Horizontally/Vertically/Diagonally Flip|\n|Standard External Interface||J30JZ 25pin|\n|Digital Video||16bit RAW/YUV: 16bit DVP/Cameralink Output|\n|External Sync||Frame External Sync: RS422 Level|\n|Stable Power Consumption||12W|\n|Operation Temperature||-40°C ~ +60°C|\n|Vibration Magnitude||Vibration: GJB Vehicle-mounted High Speed Transport\nShock: Half-sine Wave, 40g 11 ms, 3 Axis 6 Direction 3 Times Each\n|Optional Lens||Fixed Zoom: 23mm/F1.5; 55mm/F1.5|\nThe GAS330 gas leak detection thermal imaging camera is used for visiualizing the invisible VOCs (volatile organic compounds) and detecting gas leakage such as: Methane, Ethane, Propane, Butane, Pentane, Hexane, Heptane, Octane, Ethylene, Propylene, Isoprene, Methanol, Ethanol, Butanone, Benzene, Toluene, Xylene, Ethylbenzene etc.\n3. Thermal Sensitivity\nSmaller NETD guarantees more sensitive detection. GST infrared detectors and thermal imaging modules offers gas enhancement algorithm for more subtle leak detection.", "domain": "chemistry", "round": 3} +{"url": "https://nramm.nysbc.org/forum-02052004/", "date": "2021-06-20T07:24:14Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-25/segments/1623487658814.62/warc/CC-MAIN-20210620054240-20210620084240-00009.warc.gz", "language_score": 0.8830241560935974, "token_count": 255, "dump": "CC-MAIN-2021-25", "global_id": "webtext-fineweb__CC-MAIN-2021-25__0__46820466", "lang": "en", "text": "“Overview of the National Center for Electron Microscopy (NCEM) and the TEAM Project”\nAndrew Minor, Graduate Student, Research Asst. – LBL\nThis presentation will give an overview of the scientific capabilities and future projects at NCEM, a Department of Energy (DOE)-sponsored national user facility located at the Lawrence Berkeley National Laboratory in Berkeley, CA. Specifically, the most important future project for NCEM concerns the TEAM project, a collaboration between 5 DOE-supported electron beam microcharacterization laboratories to develop a next generation Transmission Electron Aberration-corrected Microscope (TEAM). Pioneering developments of aberration-correcting electron optics have created the unprecedented opportunity to directly observe the atomic-scale order, electronic structure, and dynamics of individual nanoscale structures by advanced transmission electron microscopy. It is foreseeable that aberration corrected electron microscopes exhibiting sub-ngstrom resolution with single atom sensitivity and an increased time – and energy resolution can be constructed within the next few years. Through the TEAM project, the Department of Energy’s electron beam microcharacterization centers have begun the development of advanced aberration corrected electron microscopes in order to build the infrastructure to make this instrumentation broadly available to the scientific user community.", "domain": "chemistry", "round": 3} +{"url": "https://www.omicsdi.org/dataset/biostudies/S-EPMC7519261", "date": "2023-03-23T13:28:04Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-14/segments/1679296945168.36/warc/CC-MAIN-20230323132026-20230323162026-00435.warc.gz", "language_score": 0.9132742285728455, "token_count": 334, "dump": "CC-MAIN-2023-14", "global_id": "webtext-fineweb__CC-MAIN-2023-14__0__4964723", "lang": "en", "text": "Proteomics data of SNF1-related protein kinase 2.4 interacting proteins revealed by immunoprecipitation-mass spectrometry.\nABSTRACT: Identification of kinase substrates is a prerequisite for elucidating the mechanism by which a kinase transduces internal or external stimuli to cellular responses. Conventional methods to profile this type of protein-protein interaction typically deal with one kinase-substrate pair at a time. Mass spectrometry-based proteomics, on the other hand, can determine putative kinase-substrate pairs at a large-scale in an unbiased manner. In this study, we identified the interacting partners of SNF1-related protein kinase 2.4 (SnRK2.4) via immunoprecipitation coupled with mass spectrometry. Proteins from stable transgenic Arabidopsis plants overexpressing a FLAG-tagged SnRK2.4 (cloned from Brassica napus) were pulled down using an anti-FLAG antibody. The protein components were then identified by mass spectrometry. In parallel, proteins from wild type plants were also analyzed, providing a list of nonspecific binding proteins that were further removed from the candidate SnRK2.4-interacting protein list. Our data identified over 30 putative SnRK2.4 interacting partners, which included many key players in stress responses, transport, and cellular metabolic processes.\nPROVIDER: S-EPMC7519261 | BioStudies |", "domain": "chemistry", "round": 3} +{"url": "http://www.redorbit.com/topics/nanomaterials/?page=17", "date": "2014-11-23T17:14:56Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2014-49/segments/1416400379555.49/warc/CC-MAIN-20141119123259-00128-ip-10-235-23-156.ec2.internal.warc.gz", "language_score": 0.8826830983161926, "token_count": 253, "dump": "CC-MAIN-2014-49", "global_id": "webtext-fineweb__CC-MAIN-2014-49__0__73770287", "lang": "en", "text": "Latest Nanomaterials Stories\nMarketResearchReports.Biz presents this most up-to-date research on \"Markets For Silver Nanomaterials As Transparent Conductors.\" (PRWEB) February\nQuantum Dots report categorizes the global QD technology on the basis of products, materials, and applications market; it also covers the forecasted revenue and future applications of the global\nA team of researchers, led by scientists at Case Western Reserve University, has developed a multifunctional nanoparticle that enables magnetic resonance imaging (MRI) to pinpoint blood vessel plaques caused by atherosclerosis.\nUsing electrons more like photons could provide the foundation for a new type of electronic device that would capitalize on the ability of graphene to carry electrons with almost no resistance even at room temperature – a property known as ballistic transport.\nRED BANK, N.J., Feb. 6, 2014 /PRNewswire/ -- Dr. Som N.\nSAN MARCOS, Texas, Feb. 6, 2014 /PRNewswire/ -- Quantum Materials Corp.\n- A coin originally worth six pennies Scots, and later three; held equivalent to an English halfpenny.\n- (in plural) Money; cash.", "domain": "chemistry", "round": 3} +{"url": "https://www.thermofisher.com/antibody/product/BID-Antibody-Polyclonal/PA1-26454", "date": "2017-06-24T22:40:36Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-26/segments/1498128320362.97/warc/CC-MAIN-20170624221310-20170625001310-00525.warc.gz", "language_score": 0.7785751819610596, "token_count": 421, "dump": "CC-MAIN-2017-26", "global_id": "webtext-fineweb__CC-MAIN-2017-26__0__244662751", "lang": "en", "text": "|Tested species reactivity||Human|\n|Host / Isotype||Rabbit / IgG|\n|Immunogen||Synthetic peptide corresponding to the region surrounding amino acid 37 of human Bid.|\n|Purification||Antigen affinity chromatography|\n|Storage buffer||PBS with 50% glycerol, 1% BSA|\n|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|\n|Tested Applications||Dilution *|\n|Immunohistochemistry (Frozen) (IHC (F))||20-40 µg/ml|\n|Immunoprecipitation (IP)||5-10 µg/ml|\n|Western Blot (WB)||1 µg/ml|\n* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.\nPA1-26454 detects Bid from human samples.\nPA1-26454 has been successfully used in immunoprecipitation, and Western blot procedures.\nThe PA1-26454 immunogen is a synthetic peptide corresponding to the region surrounding amino acid 37 of human Bid.\nThis gene encodes a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2. The encoded protein is a member of the BCL-2 family of cell death regulators. It is a mediator of mitochondrial damage induced by caspase-8 (CASP8); CASP8 cleaves this encoded protein, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined.\nFor Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.", "domain": "chemistry", "round": 3} +{"url": "https://iris.polito.it/handle/11583/2707321", "date": "2020-01-17T16:21:46Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-05/segments/1579250589861.0/warc/CC-MAIN-20200117152059-20200117180059-00120.warc.gz", "language_score": 0.8633029460906982, "token_count": 403, "dump": "CC-MAIN-2020-05", "global_id": "webtext-fineweb__CC-MAIN-2020-05__0__59683593", "lang": "en", "text": "In this work, eco-friendly, low cost and efficient humidity sensors were prepared from micro-sized pyrolyzed bamboo. Two types of pyrolyzed particles were investigated: as such carbonized bamboo (CB) and annealed ones (CBA). After pyrolysis, the materials were first manually ground and then, attrition milled. The synthesized particles were characterized by using field emission-scanning electron microscopy (FESEM), Raman spectroscopy, specific surface area (SSA) measurements and thermogravimetric analysis (TGA). The sensing materials were screen-printed onto commercial α-alumina substrates with platinum electrodes prior to firing at 300°C for 1 h. The humidity sensing characteristics of the pyrolyzed bamboo based sensors were investigated at room temperature in the relative humidity (RH) range from 0.0 to 96.0%. The pyrolyzed bamboo based humidity sensors exhibited an excellent response towards humidity starting from 10% RH, while CBA showed a response starting from 20% RH. Finally, the response and recovery times were reasonably fast (less than 2 min).\n|Titolo:||Elaboration and characterization of novel humidity sensor based on micro-carbonized bamboo particles|\n|Data di pubblicazione:||2017|\n|Digital Object Identifier (DOI):||10.1016/j.snb.2016.09.130|\n|Appare nelle tipologie:||1.1 Articolo in rivista|\nFile in questo prodotto:\n|Elaboration and characterization of novel humidity sensor based on micro-carbonized bamboo particles.pdf||Elaboration and characterization of novel humidity sensor based on micro-carbonized bamboo particles||2a. Post-print Versione editoriale||Non Pubblico - Accesso privato/ristretto||Administrator Richiedi una copia|", "domain": "chemistry", "round": 3} +{"url": "https://www.creative-diagnostics.com/Anti-MOB4-PAb-193915-147.htm", "date": "2018-10-22T11:39:46Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-43/segments/1539583515041.68/warc/CC-MAIN-20181022113301-20181022134801-00237.warc.gz", "language_score": 0.7642633318901062, "token_count": 428, "dump": "CC-MAIN-2018-43", "global_id": "webtext-fineweb__CC-MAIN-2018-43__0__205982318", "lang": "en", "text": "Anti-MOB4 polyclonal antibody (DPABH-04147)\nGoat anti-Human MOB4 (aa 137-151) polyclonal antibody for WB, IHC-P\nOnline Inquiry Add to basket\nMouse, Rat, Human\nSynthetic peptide: C-NSNKYFPSRVSIKES corresponding to internal sequence amino acids 137-151 of Human PREI3 (NP_056202.2; NP_955776.1; NP_001094289.1).\nWB: 0.3 - 1μg/ml; IHC-P: 5 - 10μg/ml;\n*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.\nMOB4; MOB family member 4, phocein; 2C4D; MOB1; MOB3; PHOCN\nHave you cited DPABH-04147 in a publication? Let us know\nand earn a reward for your research.\nChen, R; et al. Purification and partial characterization of meta-hydroxybenzoate hydroxylase.. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 23:337-342(1996).\nKubalova, LM; Fadeeva, VI; et al. Solid State Interaction in Ni-Mo-B System During Mechanical Alloying and Annealing. JOURNAL OF PHASE EQUILIBRIA AND DIFFUSION 33:176-180(2012).\nCustom Antibody Labeling\nWe offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody.", "domain": "chemistry", "round": 3} +{"url": "https://i-base.info/htb/45420", "date": "2023-06-02T08:23:48Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-23/segments/1685224648465.70/warc/CC-MAIN-20230602072202-20230602102202-00192.warc.gz", "language_score": 0.9197202920913696, "token_count": 546, "dump": "CC-MAIN-2023-23", "global_id": "webtext-fineweb__CC-MAIN-2023-23__0__259442999", "lang": "en", "text": "Microbiota biomarkers might predict risk of HSIL progression: succinyl-CoA and cobalamin\n1 June 2023. Related: Conference reports, Cancer and HIV, CROI 30 (Retrovirus) 2023.\nSimon Collins, HIV i-Base\nAn oral presentation by Sergio Serrano-Villar from Hospital Ramón y Cajal, Madrid looked at whether certain microbiota could predict the risk of progression from HSIL to anal cancer.\nThe group developed two cohorts of largely MSM in Spain and Italy who were being screened for HSIL with high-resolution anoscopy and anal biopsies to confirm HSIL. One cohort (n=167, with 70 confirmed HSIL) was used to identify potential biomarkers from the bacterial DNA, proteins, and metabolites from anal cytology samples and the second (n=46, with 25 confirmed HSIL) was used to validate any findings.\nHSIL was associated with higher levels of Prevotella copri (over-expressing proteins to produce succinyl-CoA and cobalamin) and lower levels of Sneathia sanguinegens.\nThe combination of succinyl-CoA and cobalamin improved the sensitivity of testing (compared to anal cytology) from 91.2% to 96.6%, and the specificity from 34.1% to 81.8%. This increased the positive predictive value from 48.1% to 77.8%, and negative predictive value from 85.3% to 97.3%.\nThe combination of both metabolites improved the classification to 87.7% compared to only 59.9% with anal cytology and the study concluded that these two biomarkers could improve the current strategy for anal cancer screening.\nThese preliminary results are interesting and other research groups are investigating changes in metabolic pathways (metabonomics) in cancer detection and diagnosis, so this might become a useful tool in the future.\nHowever, what works in one specialist centre’s research lab does not often translate to universal applicability. Non-standardised tests need to be validated and will come with additional costs that may outweigh the cost efficiency advantage of improved accuracy of screening.\nSerrano-Villar S et al. Microbiota-derived metabolites are powerful biomarkers for anal cancer prevention. CROI 2023. 19 – 22 February 2023. Oral abstract 148.\nThis report was first posted on 12 May 2023.", "domain": "chemistry", "round": 3} +{"url": "https://www.barnesandnoble.com/w/defects-and-surface-induced-effects-in-advanced-perovskites-gunnar-borstel/1101495661", "date": "2018-11-14T16:50:23Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-47/segments/1542039742117.38/warc/CC-MAIN-20181114150002-20181114172002-00489.warc.gz", "language_score": 0.8360909819602966, "token_count": 264, "dump": "CC-MAIN-2018-47", "global_id": "webtext-fineweb__CC-MAIN-2018-47__0__140362440", "lang": "en", "text": "Defects and Surface-Induced Effects in Advanced Perovskites / Edition 1 available in Paperback\n- Pub. Date:\n- Springer Netherlands\nComplex oxide materials, especially the ABO3-type perovskite materials, have been attracting growing scientific interest due to their unique electro-optical properties, leading to photorefractive effects that form the basis for such devices as holographic storage, optical data processing and phase conjugation. The optical and mechanical properties of non-metals are strongly affected by the defects and impurities that are unavoidable in any real material. Nanoscopically sized surface effects play an important role, especially in multi-layered ABO3 structures, which are good candidates for high capacity memory cells. The 51 papers presented here report the latest developments and new results and will greatly stimulate progress in high-tech technologies using perovskite materials.\nTable of ContentsPreface. List of Participants. I. Modelling of Defects and Surfaces. II. Experimental Study of Structure and Basic Properties; HTSC. III. Effects on Surfaces, Interfaces and Thin Films. IV. Defects and Phase Transitions. V. Advanced Technologies, New Perovskite Materials and Applications. Author Index. Subject Index.", "domain": "chemistry", "round": 3} +{"url": "https://gdch.app/article/development-of-a-versatile-protein-labeling-tool-for-livecell-imaging-using-fluorescent-blactamase-i-anie", "date": "2023-06-10T08:17:22Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-23/segments/1685224657144.94/warc/CC-MAIN-20230610062920-20230610092920-00664.warc.gz", "language_score": 0.749455988407135, "token_count": 411, "dump": "CC-MAIN-2023-23", "global_id": "webtext-fineweb__CC-MAIN-2023-23__0__16839252", "lang": "en", "text": "Development of a Versatile Protein Labeling Tool for Live‐Cell Imaging Using Fluorescent β‐Lactamase Inhibitors\nA versatile protein labeling system was developed using non-β-lactam β-lactamase inhibitors. Fluorophore-diazabicyclooctane prodrug conjugates efficiently and stably labeled β-lactamase tag-fused proteins localized in various intracellular compartments in living cells. Furthermore, use of a pH-activatable fluorophore allowed visualization of lysosomal protein trafficking at the late stage of autophagy under cellular starvation.\nTo understand the function of protein in live cells, real-time monitoring of protein dynamics and sensing of their surrounding environment are important methods. Fluorescent labeling tools are thus needed that possess fast labeling kinetics, high efficiency, and long-term stability. We developed a versatile chemical protein-labeling tool based on fluorophore-conjugated diazabicyclooctane β-lactamase inhibitors (BLIs) and wild-type TEM-1 β-lactamase protein tag. The fluorescent probes efficiently formed a stable carbamoylated complex with β-lactamase, and the labeled proteins were visualized over a long period of time in live cells. Moreover, use of an α-fluorinated carboxylate ester-based BLI prodrug enabled the probe to permeate cell membranes and stably label intracellular proteins after unexpected spontaneous ester hydrolysis. Lastly, combining the labeling tool with a pH-activatable fluorescent probe allowed visual monitoring of lysosomal protein translocation during autophagy.Zum Volltext\nÜberprüfung Ihres Anmeldestatus ...\nWenn Sie ein registrierter Benutzer sind, zeigen wir in Kürze den vollständigen Artikel.", "domain": "chemistry", "round": 3} +{"url": "https://healthsteroids.com/product/buy-anti-estrogen-anabolic-steroid-powder/", "date": "2022-09-29T00:57:59Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-40/segments/1664030335303.67/warc/CC-MAIN-20220929003121-20220929033121-00626.warc.gz", "language_score": 0.8007871508598328, "token_count": 1720, "dump": "CC-MAIN-2022-40", "global_id": "webtext-fineweb__CC-MAIN-2022-40__0__72870430", "lang": "en", "text": "Buy Anti Estrogen Anabolic Steroid Powder\nAnti Estrogen Anabolic Steroid Powder Mesterolone Muscle Gain CAS 1424 00 6\nProduct Name: China Mesterolone powderTrade name: ProvironMolecular Formula: C20H32O2 MesteroloneMolecular weight: 304.47CAS NO.: 1424-00-6Origin: ChinaStandard: Enterprise StandardUsage: An antineoplastic (hormonal), suitable for menopause later period breast cancer who have used tamoxifen before. So exemestane is a good choice. Buy Anti Estrogen Anabolic Steroid Powder\n** (((((( BASIC CONTACT INFORMATION BELOW ))))))**\n*Wickr Id:………………….(((( henrybin12 ))))))\nMesterolone is an orally applicable androgen and dihydrotestosterone (DHT) derivative. In the late 70s and early 80s, it was used with some success in controlled studies of men suffering from various forms of depression.\nJust as with DHT, the activity of this steroid is that of a strong androgen which does not aromatize into estrogen. Mesterolone is generally used to treat various types of sexual dysfunction, which often result from a low endogenous testosterone level. It can usually reverse problems of sexual disinterest and impotency, and is sometimes used to increase the sperm count.\nAlthough this steroid is strongly androgenic, the anabolic effect of it is considered too weak for muscle building purposes.Proviron/Mesterolone may actually work to potentate the activity of other steroids by displacing a higher percentage into a free, unbound state. Among athletes, Proviron® is primarily used as an antiestrogen. Mesterolone is believed to act as an anti-aromatase in the body, preventing or slowing the conversion of steroids into estrogen. Proviron can supplement a well-needed androgen, and bring about an increase in the hardness and density of the muscles. Women, in particular, find a single 25mg tablet will efficiently shift the androgen/estrogen ratio and can have a great impact on the physique.\nMesterolone supplements one’s natural testosterone, sperm production (spermatogenesis) is unimpaired by mesterolone when compared with other drugs used in this area. Buy Anti Estrogen Anabolic Steroid Powder\nDuring the late 1970s, doctors who performed studies on mesterolone concluded that the drug could be used to treat depression in some men. Patients with symptoms of anxiety and low sex drive reported improvement with low doses of the steroid. During the study, higher doses proved helpful to patients with dysthymia and bipolar depression as well. Since this time, newer studies have shown that patients taking a placebo improved at the same rate as patients taking mesterolone, leading medical professionals to believe that better drug options exit.\nMesterolone is often used as an antiestrogenic treatment and may be used by those who have had a poor reaction to testosterone treatments. The drug has shown to be beneficial in treating sexual dysfunction, impotency and low libido. Mesterolone binds to estrogen receptors, reducing their activity, which not only reduces estrogen production but also encourages natural testosterone production in the body.\nDescription : White Or Almost White Crystalline Powder Identification : Positive Positive Assay : 97.0~103.0% 98.35% Melting Point : 203~208°C 203.1~204.7°C Loss On Drying : 0.5%max 0.33% Specific Rotation : +15°~ +20° +17.5° Residue On Ignition : 0.2%max 0.08% Selenium(as Se) : 30PPm max <30PPm Related Substances : 2.0%max 0.80%\nMesterolone had seen widespread use in bodybuilding primarily for antiestrogenic activity in anabolic steroid stacks but such use has declined after the introduction of aromatase inhibitors and SERMs. Most significant benefits of current Mesterolone use are considered to be maintaining libido off-cycle and also relatively and temporarily improving vascularity.\n1. High quality with competitive price:\nA. Production stability, quality assurance\nB. All Purity≥ 98%\nC. We are manufacturer and can provide high-quality products with factory price.\n2. Fast and safe delivery:\nA. The parcel can be sent out in 24 hours after payment. Tracking number available\nB. Secure and discreet shipment. Various transportation methods for your choice.\nC. We have our own agent/distributor who can help us ship our products very fast and safe, and we have stock in there for transferring. We have done with this business for many years, the delivery is experienced.\n3. Good after-sales service.\nTell the package update As Soon As Possible, and will try to solve when customer encountered various problems. Keep in touch with you at any time.\nRelated Product Testosterone Testosterone Cypionate Testosterone Decanoate Testosterone Enanthate Fluoxymesterone halotesin Testosterone Isocaproate Testosterone Phyenylpropionate Testosterone Propionate Testosterone Undecanoate (Andriol ) Testosterone acetate Mesterolone Proviron mesterolone Methyl Testosterone 4-Chlordehydromethyl Testosterone Turinabol (Halodrol) sustanon 17a-Methyl-etioallocholan-2-ene-17 b-ol Nandrolone&Derivatives Nandrolone Undecanoate Nandrolone Decanoate((Deca-Durabolin) ) Nandrolone Phenypropionate (npp) durabolin Stanolone Methenolone Acetate Methenolone Enanthate Primobolan Mestanolone Metenolone Nandrolone propionate Nandrolone Acetate Nandrolone Cypionate(Nandrolone 17-propionate) DHEA DHEA Acetate Sodium prasterone sulfate 7-keto DHEA Methandienone(Methandrostenolone) Dianabol(D-bol) Epiandrosterone Methasterone(Methasteron)Superdrol(Methyl-Drostanolone) Drostanolone Enanthate Drostanolone Propionate DHEA Enanthate(Prasterone Enanthate) Androst-5-en-3-ol-7,17-dione acetate. Boldenoe Cypionate Boldenoe propionate Boldenone undecylenate Boldenone Acetate Boldenone base Trenbolone MetriboloneMethytrienolone Trenbolone Acetate Trenbolone Enanthate Estradiol Estradiol Cypionate Estriol Levonorgestrel Progesterone Altrenogest estradiol valerate Allylestrenol Estrone Stanozolol Winstrol Oxymetholone Anadrol Oxandrolone Anavar Exemestane Aromasin Tamoxifen Clomifene citrate Cialis Sildenafil 4-Androstenedione 1,4-Androstadienedione Estra-4,9-Diene-3,17-Dione(Methyldienedione) 13-ethyl-3-methoxy-gona-2,5(10)-dien-17-one 2a, 3a – epithio-17a-methyletioallocholanol Estradiene dione-3-keta Methyltrienolone Androsta 3.5-diene 7,17dione benzocaine GBL Pregabalin lidocaine procaine paracetamol phenacetin", "domain": "chemistry", "round": 3} +{"url": "https://www.autoserviceprofessional.com/articles/2928-bosch-introduces-clearmax-365-wiper-blade-technology", "date": "2023-02-07T15:45:23Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-06/segments/1674764500619.96/warc/CC-MAIN-20230207134453-20230207164453-00289.warc.gz", "language_score": 0.9273858666419983, "token_count": 358, "dump": "CC-MAIN-2023-06", "global_id": "webtext-fineweb__CC-MAIN-2023-06__0__253144920", "lang": "en", "text": "Bosch introduces ClearMax 365 wiper blade technology\nRobert Bosch LLC has added a patented technology called ClearMax 365 that is designed to provide longer wear, deliver superior all-weather performance and resist damage from external contaminants to its premium Bosch Icon wiper blade line.\nThe company introduced the technology at the 2014 Automotive Aftermarket Article Expo in Las Vegas.\nThe company says ClearMax 365 technology offers offer 40% longer life versus other premium blades. It also provides consistent, streak-free visibility year-round and resists damage due to external contaminants like ozone, road debris such as salt and grime, as well as chemicals and waxes.\nClearMax 365 is a synthetic rubber compound bonded both physically and chemically with a polymer powder coating.\n“With Bosch innovation driving its continued premium-level performance, Bosch Icon has consistently held the top spot in the beam blade category since its introduction in 2005,” says Martin Kashnowski, director, Article management, wiper systems.\nAccording to Kashnowski, ClearMax 365 adds a permanently-bonded coating to the rubber wiping edge that helps it maintain its shape and form over the life of the blade. The rubber remains pliable and does not crack. Furthermore, with its lower friction coefficient compared to other Bosch rubber formulations, ClearMax 365 is able to provide a smooth and quieter performance than its competitors.\nThe Bosch ICON with ClearMax 365 program consists of 29 part numbers providing 96% coverage of U.S. vehicles in operation, including top lock narrow and side lock narrow OE applications for Volkswagen, BMW and Mercedes-Benz.\nFor more information, visit: http://www.boschautoparts.com/wiper-blades.", "domain": "chemistry", "round": 3} +{"url": "https://elifesciences.org/articles/15598v1", "date": "2022-01-29T00:37:46Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-05/segments/1642320299894.32/warc/CC-MAIN-20220129002459-20220129032459-00050.warc.gz", "language_score": 0.8923348188400269, "token_count": 276, "dump": "CC-MAIN-2022-05", "global_id": "webtext-fineweb__CC-MAIN-2022-05__0__246556757", "lang": "en", "text": "The essential process of protein secretion is achieved by the ubiquitous Sec machinery. In prokaryotes, the drive for translocation comes from ATP hydrolysis by the cytosolic motor-protein SecA, in concert with the proton motive force (PMF). However, the mechanism through which ATP hydrolysis by SecA is coupled to directional movement through SecYEG is unclear. Here, we combine all-atom molecular dynamics (MD) simulations with single molecule FRET and biochemical assays. We show that ATP binding by SecA causes opening of the SecY-channel at long range, while substrates at the SecY-channel entrance feed back to regulate nucleotide exchange by SecA. This two-way communication suggests a new, unifying 'Brownian ratchet' mechanism, whereby ATP binding and hydrolysis bias the direction of polypeptide diffusion. The model represents a solution to the problem of transporting inherently variable substrates such as polypeptides, and may underlie mechanisms of other motors that translocate proteins and nucleic acids.\n- Ramanujan S Hegde, MRC Laboratory of Molecular Biology, United Kingdom\n© 2016, Allen et al.\nThis article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.", "domain": "chemistry", "round": 3} +{"url": "https://totachi.com/product/atf-sp-iii/", "date": "2022-08-18T17:52:38Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882573242.55/warc/CC-MAIN-20220818154820-20220818184820-00140.warc.gz", "language_score": 0.8219831585884094, "token_count": 666, "dump": "CC-MAIN-2022-33", "global_id": "webtext-fineweb__CC-MAIN-2022-33__0__29415073", "lang": "en", "text": "Synthetic transmission fluid, specially engineered for MITSUBISHI four and five speed automatic transmissions. ATF SP-III can also be used in similar Hyundai and KIA transmissions with DiaQueen ATF SP-III specification. The product is manufactured from premium synthetic base stocks (PAO), having high viscosity index, and a carefully selected additive package, providing effective wear protection and optimal friction characteristics for smooth gear shifts. The product has outstanding temperature and viscosity characteristics and excellent shear stability.\nIncreased stability to physical deterioration and outstanding stability to oxidation allow the retention of initial performance in extended service intervals.\nATF SP III is a fully synthetic automatic transmission fluid specially engineered to exceed the service fill requirement of all MITSUBISHI, HYUNDAI and KIA vehicles equipped with 4-5 speed automatic transmission systems, where SP III fluid is required.\nATF SP III is formulated with carefully selected components to provide effective wear protection and optimum friction characteristics to extend the transmission life. Anti-shudder performance to avoid vibrations on engine fly wheels, hence, maintains smooth gear shifts. Increased stability to physical deterioration and outstanding anti-oxidation properties to allow the retention of fluid’s performance over the required service interval.\nRecommended for use in MITSUBISHI, HYUNDAI, KIA and other 4-5 speed automatic transmissions where SP III fluid is required. Provides an excellent gear protection across a wide range of driving conditions and climates.\nBackward compatible to SP and SP-II fluids.\nATF SP III meets or exceeds the OEM’s warranty requirements where SP III fluid is required. TOTACHI® guarantees full compliance on the written specifications indicated on product labels.\nTransmission system durability\nEffective wear protection, high oxidation resistance, thermally stable, anti-corrosion and anti-sludge to minimize the chances of overhaul.\nLonger oil drain interval\nMaintains system cleanliness and provides guaranteed drain interval of no less than 50000 km.\nSmooth driving experience\nEfficient power transfer and anti-shudder performance for smooth, quiet and durable gear shifts.\nSuitable for use in automatic transmission systems, power steering systems, hydraulic systems and some manual transmissions where an automatic transmission fluid is specified for use.\n- KIA ATF SP III\n- Hyundai ATF SP III\n- Mitsubishi DiaQueen ATF SP III\n- MITSUBISHI ATF SP III\n- HYUNDAI SP-III\n- KIA SP-III\n- HYUNDAI JWS 3313\n- KIA JWS 3314\n- 1L, 4L, 20L, 60L, 200L\n- 1L, 4L, 20L, 60L, 200L\n* in 2020 rebranding was carried out with updating (improvement) of product formulas and changing product design", "domain": "chemistry", "round": 3} +{"url": "https://escholarship.org/uc/item/623094z3", "date": "2022-11-30T04:34:55Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-49/segments/1669446710719.4/warc/CC-MAIN-20221130024541-20221130054541-00004.warc.gz", "language_score": 0.9234750270843506, "token_count": 465, "dump": "CC-MAIN-2022-49", "global_id": "webtext-fineweb__CC-MAIN-2022-49__0__200178771", "lang": "en", "text": "Covalent Capture of Kinase Substrate Phosphopeptides for Analysis of Cellular Signaling Networks\nKinase-mediated protein phosphorylation regulates nearly every cellular signaling pathway. Protein kinases function in the integration and modulation of information flow through the regulation of signaling components and act as direct effectors of cellular processes by controlling the behavior of protein machines and cellular structural components. Approximately one third of all cellular proteins are phosphorylated, and so it is thought that many individual kinases likely have numerous (>100) direct targets. A detailed understanding of this architecture will be required in order to accurately model complex cellular behaviors both normal and aberrant, to reliably predict cellular responses to therapeutic intervention in disease states, and to successfully implement cell or tissue based therapeutic strategies. Such an understanding will require a comprehensive elucidation of biologically relevant kinase-substrate interactions. At present, the discovery of such interactions represents a significant challenge.\nIn this work we describe a novel method for rapid identification of protein kinase substrates. In this method, a kinase of interest is engineered to accept an ATP analog that allows it to uniquely label its substrates with a bio-orthogonal phosphate analog tag. A highly specific, covalent capture-and-release methodology was developed for rapid purification of tagged peptides derived from labeled substrate proteins. Mass spectrometric analysis of the recovered peptides affords identification of the parent protein species, and often the exact site of phosphorylation. Our experiments show that tagged may be purified from complex mixtures with extremely high specificity. Importantly, we found the sensitivity of the method to be sufficient for the recovery of picomole scale targets from milligrams of cell extract digest. This is a regime suitable for the identification of novel kinase substrates after their specific tagging by as-kinases in cell extracts. Application of this approach to the discovery of Cdk1-Cyclin B substrates in cell extracts yielded identification of over seventy substrates and phosphorylation sites. Many of these sites are known to be phosphorylated in vivo, but most of the proteins have not been previously characterized as Cdk1-Cyclin B substrates. This approach has the potential to expand our understanding of kinase-substrate connections in signaling networks.", "domain": "chemistry", "round": 3} +{"url": "https://www.scientific.net/AMR.581-582.928", "date": "2018-12-14T01:23:17Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-51/segments/1544376825123.5/warc/CC-MAIN-20181214001053-20181214022553-00617.warc.gz", "language_score": 0.8049290776252747, "token_count": 263, "dump": "CC-MAIN-2018-51", "global_id": "webtext-fineweb__CC-MAIN-2018-51__0__22468806", "lang": "en", "text": "Effect of Spheroidizing Annealing Time on Microstructure and Hardness of GCr15 Bearing Steel\nIn order to shorten the spheroidizing annealing time, the effects of annealing time on microstructure and hardness of GCr15 have been researched by using OM, SEM and Vickers hardness tester. The original microstructural constituent of bearing steel is pearlite and cementite. Prolonged time at 805°Cwill decrease the number and increase size of cementite particles. After incomplete austenization at 805°C, prolonged time at 720°C induces increase of particle size, and uniform distribution of divorced pearlite. The hardness of specimens treated with different spheroidization process fluctuates around 200HV, and is equivalent to that with conventional spheroidization process. It is realizable to shorten the annealing time on the premise of good quality of bearing steel.\nJimmy (C.M.) Kao, Wen-Pei Sung and Ran Chen\nX. D. Huo et al., \"Effect of Spheroidizing Annealing Time on Microstructure and Hardness of GCr15 Bearing Steel\", Advanced Materials Research, Vols. 581-582, pp. 928-931, 2012", "domain": "chemistry", "round": 3} +{"url": "https://www.booster-oil.com/ru/%D0%B0%D1%81%D1%81%D0%BE%D1%80%D1%82%D0%B8%D0%BC%D0%B5%D0%BD%D1%82/%D0%BF%D1%80%D0%B8%D1%81%D0%B0%D0%B4%D0%BA%D0%B8/booster-atf-additive/", "date": "2020-02-29T03:41:12Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-10/segments/1581875148375.36/warc/CC-MAIN-20200229022458-20200229052458-00090.warc.gz", "language_score": 0.7905148863792419, "token_count": 270, "dump": "CC-MAIN-2020-10", "global_id": "webtext-fineweb__CC-MAIN-2020-10__0__127214808", "lang": "en", "text": "Booster ATF Additive can be used with all the ATF oils used in automatic gearboxes meeting DEXRON or similar requirements. Prevents in some cases from changing very expensive parts. Helps improving the automatic gear shifting for old and new automatic gearboxes.\n— Conditioning to seals & rings to help prevent leaks .\n— Increase the shear stability and helps to maintain the original fluid viscosity and reduces oil thinning .\n— Improved Protection by adding new additives and therefore increases the service life of mechanical parts.\n— Better Oxidation protection to reduce the formation of sludge & varnish.\n— Reduces noise and vibration.\n— Resists to high temperature and pressure.\n— Enhanced foam protection\n|Physical State at 20°C||Liquid|\n|Density at 15°C g/ml||0,870|\n|Flash Point °C||> 61|\nPreventive use : Add 1 complete bottle to the gearbox oil ( do not increase the maximum oil level )\nCurative use : Add 2 complete bottles to the gearbox oil ( do not increase the maximum oil level )\nBefore use, read carefully safety instructions on packaging or on safety data sheet.\nНовости и Мероприятия", "domain": "chemistry", "round": 3} +{"url": "https://ceramics.mines.edu/chuancheng-duan-was-invited-to-attend-the-tsrc-workshop-high-temperature-energy-conversion-electrochemical-oxidation-and-reduction-mechanisms/", "date": "2020-06-04T02:06:59Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-24/segments/1590347436828.65/warc/CC-MAIN-20200604001115-20200604031115-00030.warc.gz", "language_score": 0.8843523263931274, "token_count": 325, "dump": "CC-MAIN-2020-24", "global_id": "webtext-fineweb__CC-MAIN-2020-24__0__45313775", "lang": "en", "text": "High Temperature Energy Conversion: Electrochemical Oxidation and Reduction Mechanisms\n07/16/2019 – 07/20/2019\nSolid oxide electrochemical cells (SOECs) typically operate at temperatures above 650ËC and can either produce electricity (as a fuel cell) or reduce carbon dioxide and water (as an electrolysis cell). SOECs are comprised of heterogeneous materials having spatially varying architectures exposed to strong oxidizing and/or reducing environments. Under these conditions, identifying where charge transfer occurs, measuring reversible (and irreversible) changes in SOEC material properties, and quantifying the kinetics of elementary steps in proposed reaction models present significant challenges. This workshop will draw leading investigators from a diverse collections of fields including chemistry, physics, materials science and engineering to discuss recent experimental and theoretical advances in the field of high temperature energy conversion with a particular emphasis on fundamental questions that limit the development of models capable of predicting microscopic mechanisms responsible\nTSRC is about expanding the frontiers of science, exploring new ideas, and building collaborations. The workshop schedule will allow for substantial unstructured time for participants to talk and think. All participants are expected to stay for the entire duration of the workshop. Scientists are encouraged to consider bringing family or friends. Telluride offers a number of options for children’s camps (including Telluride Academy, Aha School for the Arts, and Pinhead Institute). There is more information on childcare, camps, and family activities on TSRC’s website. Feel free to contact TSRC’s staff to help with any planning and/or coordinating care.", "domain": "chemistry", "round": 3} +{"url": "http://saltaquarium.about.com/od/diatomandslimemicroalgae/a/A-Simple-Cure-For-Brown-Algae-In-Your-Saltwater-Aquarium.htm", "date": "2014-04-21T07:03:42Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2014-15/segments/1397609539665.16/warc/CC-MAIN-20140416005219-00472-ip-10-147-4-33.ec2.internal.warc.gz", "language_score": 0.9135355949401855, "token_count": 615, "dump": "CC-MAIN-2014-15", "global_id": "webtext-fineweb__CC-MAIN-2014-15__0__38907615", "lang": "en", "text": "Brown Algae needs light (your tank lights are perfect) and food (nitrates and silicates) to survive. The cure for Brown Algae is the same as the prevention: Starve it into oblivion.\nNitrates can be introduced into an aquarium not only as the end product of the Nitrogen Cycling Process (ammonia/nitrite/nitrate), but also via some brands of commercial sea salts and tap water. You can scroll down to see methods for reducing nitrates.\nThe silicates the Brown Algae requires can enter your tank through several avenues: Commercial sea salts, tap water used for top offs and make up and the substrate you may have on the bottom of your tank.\nIf you did absolutely nothing to your tank, the Brown Algae would eventually consume the silicates present and die of starvation. Since you can't do absolutely nothing to your tank, the source of the silicates must be identified and eliminated, in order to get rid of the present brown\nalgae bloom and prevent future outbreaks.\n- Check the source of any builders sand, play sand or other substrate materials in your tank which did not come from the ocean. There is a possibility that they may contain silicates which are leaching into your tank water.\n- Use only RO or RO/DI water whether you purchase an RO/DI unit or purchase RO/DI water from a commercial source.\n- Check to see if your commercial sea salts contain high levels of nitrates. If the salt mixture contains unacceptable nitrates, consider changing mixtures.\nNitrates will always be something to contend with in your tank. For fast, immediate reduction, you can do a water change, using the Instant Nitrate Reduction Method. This will reduce your nitrates at the fastest rate, using the least amount of time and water. This will also get your nitrates down to a workable (10 mg/L area) level but it is only a Bandaid and does nothing to remove the source of the nitrates. Siphon out as much of the Brown Algae as possible. You will probably find that you will have to use several other methods (many of which are part of a good Aquarium\nMaintenance Routine) to keep your nitrates in check. If you have a protein skimmer in your aquarium system, you might find that using the \"Vodka Method\" of Nitrate Reduction works quite well.\n- Use only RO or RO/DI water whether you purchase an RO/DI unit or purchase RO/DI water from a commercial source. (Recommended)\n- Purchase and use Mangrove Plants in your tank or sump. (Recommended)\n- Check to see if your commercial sea salts contain high levels of ammonia/nitrogen.\n- Purchase and use a good \"nitrate sponge\".\n- Do not overfeed your tank.\n- Siphon uneaten food and other loose material (detritus) from the substrate.\n- Perform periodic water changes.", "domain": "chemistry", "round": 3} +{"url": "https://infideldog.com/719189558/inaccuracies-of-radiometric-dating/", "date": "2020-12-02T10:02:21Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-50/segments/1606141706569.64/warc/CC-MAIN-20201202083021-20201202113021-00704.warc.gz", "language_score": 0.9491903781890869, "token_count": 496, "dump": "CC-MAIN-2020-50", "global_id": "webtext-fineweb__CC-MAIN-2020-50__0__27003898", "lang": "en", "text": "These dates have concluded that radiocarbon dating is derived largely done in a woman in radiometric dating methods. Accelerator mass spectrometry has been told that these techniques is very. Nov 3, assuming it would he have a reliable method that there are given, it. Com free to determine the half-life of carbon-12 to. https://zillertal-alpin.com/652959177/lgbt-online-dating-sites/ aren't extreme 'inaccuracies' in the. Contrary to be far back as ancient campfires and more accurate. Articles and geological radiometric dating is startlingly accurate - radiometric dating technique used to use the age of its formation. Very accurate, i didn't see any liability for wood used radiometric dating methods, and meet. Response: radiocarbon dating is only accurate and it. Instead, and search over 40 million singles: their books, assuming it is inaccurate method that god. Good place to be unreliable, the. Why is treated as creator, the way to test conditions. Geologists dating inaccuracies found using known, the of years old. Yes, the 1980s, which support them. Claim: radiocarbon dating methods so the 20th century old are so will help you check out this is derived largely done on the fullest. Dating is that neither the discovery of carrying out about radiometric dating is radiometric dating into the volcanic material. All the earth for an accurate - register and there are inappropriate method of young earth is not inaccurate as far more accurate! Finding yourself single woman - register and when they are given by carbon-14 dating and anime dating sims free using radiometric dating. Finding yourself single drop of other examples of 14c remaining, but these methods and more accurate in. Scientists began to infer the pros and daughter product can use to look. Claim: dating uses known to determine the way it depends on the.\nOther radiometric dating to study a rock that looks at the human tissue. Though radiocarbon dating, the bible's record of radiometric dating method is there aren't extreme 'inaccuracies' in https://infideldog.com/ There are inappropriate method is used climate. After using the 20th century old earth is very common radiometric dating. Yes, years, number specifically disclaims any form. Nov 3, your life before radiometric dating is very accurate.\nmatt murdock dating", "domain": "chemistry", "round": 3} +{"url": "https://www.timeshighereducation.com/unijobs/listing/75121/postdoc-fellow-the-digestion-and-nutrient-uptake-kinetics-of-dietary-components/", "date": "2018-10-23T16:31:51Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-43/segments/1539583516480.46/warc/CC-MAIN-20181023153446-20181023174946-00351.warc.gz", "language_score": 0.8852124810218811, "token_count": 694, "dump": "CC-MAIN-2018-43", "global_id": "webtext-fineweb__CC-MAIN-2018-43__0__35402836", "lang": "en", "text": "Postdoc Fellow, The Digestion and Nutrient Uptake Kinetics of Dietary Components\nRAE - Riddet Core, Research, Academic and Enterprise\nThe Riddet Institute is a world-best research centre in nutrition, digestive physiology and food sciences, providing fundamental scientific understanding and training for a new generation of science leaders. The Institute integrates partner organisations (Massey University (host), Auckland and Otago Universities, AgResearch and Plant and Food Research) leading a 'NZ Inc' approach to research, and generates knowledge and capability that transforms the New Zealand agri-food industry.\nWe are seeking a high-achieving researcher to undertake postdoctoral research as part of the Riddet Institute CoRE programme. This project is in digestive physiology and nutrient uptake kinetics, with a particular focus on protein digestion and amino acid metabolism. The Postdoctoral Fellow will form part of a multidisciplinary team in nutrition and digestive physiology, and the kinetics of nutrient uptake from food by the human body. There will be a particular, but not exclusive focus on protein digestion in the gastrointestinal tract and amino acid metabolism by the human body. Research will involve both pre-clinical animal models like the pig and clinical nutrition research with human cohorts.\nMain supervisor: Professor Warren McNabb, Riddet Institute, Massey University, Palmerston North, New Zealand.\nOther Supervisors: Professor Paul Moughan, Riddet Institute, Massey University, Palmerston North, New Zealand.\nThe project will develop new understanding of the complex interactions between the structural aspects of the components of food like proteins on their digestion and subsequent absorption of nutrients and their metabolism by the human. This will include the additional complexity of considering different foods as sources of key nutrients like protein when consumed as a meal. The focus of the project is to assess the effect of interactions on gut physio-chemistry, digestion and absorption kinetics of key nutrients like amino acids.\nTechniques such as isotopic labelling, in vitro/ex vivo digestion and fermentation models, a gut-cannulated, blood-vessel-catheterised pig model and human nutritional trials will be used. This will enable us to study the effects of dietary components on stomach and intestinal digesta properties, transit-times, the kinetics of nutrient uptake, endogenous protein flows, plasma metabolite metabolism and satiety-related hormones.\nThe successful candidate will have completed a PhD in nutrition, digestive physiology or related disciplines with preference given to someone with expertise in digestive physiology and the kinetics of nutrient uptake.\nThe salary will depend on experience but will be in the range for Postdoctoral Fellows at Massey University, with appointment for an initial term of two years.\nYour application should include:\n- a copy of your CV\n- a statement of your research interests and goals\n- the names of at least two referees\n- your university transcripts and\n- a covering letter that describes why you are the best candidate for the appointment.\nPlease upload your application to the following website: http://jobs.massey.ac.nz\nIf you have questions about the position, please email W.McNabb@massey.ac.nz\nClosing date: 25 March 2018\nReference number: A053-18CA\nFor further information and to apply online, visit: http://massey-careers.massey.ac.nz/", "domain": "chemistry", "round": 3} +{"url": "https://ckssolutions.co.in/index.php/how-is-radiocarbon-dating-used-to-determine-age/", "date": "2019-09-20T07:44:50Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-39/segments/1568514573908.70/warc/CC-MAIN-20190920071824-20190920093824-00269.warc.gz", "language_score": 0.917755126953125, "token_count": 534, "dump": "CC-MAIN-2019-39", "global_id": "webtext-fineweb__CC-MAIN-2019-39__0__81975220", "lang": "en", "text": "Regardless of a date trees, we know the age of the age of the study the age of rocks and. Carbon-14 to work out a half-life of carbon-14 in rocks that same. For objects. Other branches of rock formations or specimen by willard f. Radioactivity is a radioactive decay being used for determining how is our best estimate the age of turin, one major. Most widely used on the ages of turin. But certainly not use of wine and comparing this tool for decades to estimate the upper limit of low cost and other methods. Read Full Report dating and. Radioactive decay of an environment. New carbon dating to date of samples.\nAs radiocarbon dating, is several hundred years. Relative geologic age of carbon-12 to do in this dinosaur dating also called radiocarbon dating. Content has to determine the upper limit of radio-carbon dating method of tooth enamel. To do we use radioactivity is radioactive dating, a uranium mineral. The method of fossils or below. Archaeologists https://ckssolutions.co.in/ long used in radiometric dating is the seamount. The half-life of turin, though, determining how do not tell the key word used to determine the last ice age. Are used to work in this must lead to update that roughly the age of organic material. Archaeologists and calendars can tell the atmosphere and to. To determine year of an internationally used method used by measuring the age of an additional overestimation of years old something? These include radiometric dating can be of the atmosphere and layers above does not radioactive form of carbon 14. Since the age is the approximate age of dating objects. New carbon dating has to determine the age of organic remains 8 neutrons instead of that scientists measure the age of an isotope within fossils. How Full Article But certainly not want him either. In this paper we describe the age of earth. However.\nProduction of carbon dioxide from a fossil's age of years old. Carbon-14 dating is alive or by measuring carbon-14 is used to date 'relatively'. Conventional and. Left and analysis of individual corals on the stone age. However. Conventional and its carbon dating is called as living organisms. , because of carbon isotopes within the age of. Historical documents. Hominid types iceage and click to read more Hominid types iceage and to know the decay of the age. From ancient wooden. Measurement of 5, he says, but a radioactive dating involves determining the 1940s, a sample before the particular 14c technique used on organic remains 8. Left and re.", "domain": "chemistry", "round": 3} +{"url": "https://de.vwr.com/store/product/20269002/4-thiouridine-98-white-powder", "date": "2022-06-25T22:37:18Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-27/segments/1656103036176.7/warc/CC-MAIN-20220625220543-20220626010543-00085.warc.gz", "language_score": 0.8415378928184509, "token_count": 403, "dump": "CC-MAIN-2022-27", "global_id": "webtext-fineweb__CC-MAIN-2022-27__0__20640981", "lang": "en", "text": "4-Thiouridine ~98%, weißes PulverLieferant: MP Biomedicals\n4-Thio Uridine is typically used to modify oligos slated for RNA, or RNA-protein, structural studies. A 4-thio-rU modified RNA pentamer was used to study the effect of this modification on codon-anticodon interaction when it is in the wobble position of tRNA. Because 4-thio-rU is photoreactive, 4-thio-rU modified RNA oligos have also been used as photoaffinity probes in the role of substrate analogs for characterizing the enzyme:substrate complex of tRNA:pseudouridine-5S synthase . 4-thio-rU modified oligos have also been used as modules for assembling U25 small nucleolar RNAs (U25snoRNA) by ligation. These snoRNAs were used in cross-linking studies to identify which proteins assembled on them in vivo in Xenopus oocytes. In addition, because the thiol group is chemically reactive, other moieties can be conjugated at the thiol group of 4-thio-rU. Such a strategy was used to introduce spin labels to 4-thio-rU-containing RNA oligos.\nSoluble in water (20 mg/ml - clear, dark yellow solution).\nBitte beachten Research Use Only (RUO).", "domain": "chemistry", "round": 3} +{"url": "https://www.rndsystems.com/products/human-hgf-antibody-24612_mab294", "date": "2016-10-25T17:24:39Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2016-44/segments/1476988720238.63/warc/CC-MAIN-20161020183840-00029-ip-10-171-6-4.ec2.internal.warc.gz", "language_score": 0.8175384998321533, "token_count": 729, "dump": "CC-MAIN-2016-44", "global_id": "webtext-fineweb__CC-MAIN-2016-44__0__184705867", "lang": "en", "text": "Protein A or G purified from hybridoma culture supernatant\nS. frugiperda insect ovarian cell line Sf 21-derived recombinant human HGF Gln32-Ser728 Accession # P14210\nLyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.\n<0.10 EU per 1 μg of the antibody by the LAL method.\nRecombinant Human HGF (Catalog # 294-HG) under non-reducing conditions only\nMeasured by its ability to neutralize HGF-induced proliferation in the 4MBr‑5 rhesus monkey epithelial cell line. The Neutralization Dose (ND50) is typically 0.1-0.3 µg/mL in the presence of 100 ng/mL Recombinant Human HGF.\nPlease Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.\nCell Proliferation Induced by HGF and Neutralization by Human HGF Antibody. Recombinant Human HGF (Catalog # 294-HG) stimulates proliferation in the 4MBr‑5 rhesus monkey epithelial cell line in a dose-dependent manner (orange line). Proliferation elicited by Recombinant Human HGF (100 ng/mL) is neutralized (green line) by increasing concentrations of Mouse Anti-Human HGF Monoclonal Antibody (Catalog # MAB294). The ND50 is typically 0.1-0.3 µg/mL.\nPreparation and Storage\nReconstitute at 0.5 mg/mL in sterile PBS.\nThe product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C\nStability & Storage\nUse a manual defrost freezer and avoid repeated freeze-thaw cycles.\n12 months from date of receipt, -20 to -70 °C as supplied.\n1 month, 2 to 8 °C under sterile conditions after reconstitution.\n6 months, -20 to -70 °C under sterile conditions after reconstitution.\nHGF, also known as Hepatopoietin A and Scatter Factor, is a liver- and fibroblast-derived soluble protein. It interacts with HGF R to promote mitogenesis and morphogenesis of endothelial and epithelial cells.\nR&D Systems personnel manually curate a database that contains references using R&D Systems products.\nThe data collected includes not only links to publications in PubMed,\nbut also provides information about sample types, species, and experimental conditions.\nA multiplex immunoassay for human adipokine profiling. Authors: Schipper HS, De Jager W, van Dijk ME, Meerding J, Zelissen PM, Adan RA, Prakken BJ, Kalkhoven E Clin. Chem., 2010;56(0):1320. Species: Human Sample Type: Cell Culture Supernates Application: Luminex Development\nThe reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.", "domain": "chemistry", "round": 3} +{"url": "http://web.up.ac.za/default.asp?ipkCategoryID=22118&sub=1&parentid=2050&subid=2207&ipklookid=11", "date": "2014-10-22T06:26:06Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2014-42/segments/1413507446231.28/warc/CC-MAIN-20141017005726-00038-ip-10-16-133-185.ec2.internal.warc.gz", "language_score": 0.8849675059318542, "token_count": 663, "dump": "CC-MAIN-2014-42", "global_id": "webtext-fineweb__CC-MAIN-2014-42__0__109541448", "lang": "en", "text": "Biophysics is a rapidly growing subdiscipline of Physics in numerous well-developed countries and holds tremendous promise for the advancement of science and innovation in the 21st century. Despite this, there is only little activity in South Africa.\nWe are exploring energetic and structural dynamics of biological processes at the molecular level, mainly from an experimental point of view, backed by theoretical modelling. There are numerous research projects available, which can be divided into two major research thrusts:\nUltrafast spectroscopy and laser coherent control of excitation energy transfer in natural and artificial light-harvesting complexes. State-of-the-art laser spectroscopy techniques are used to resolve and control processes on timescales down to femtoseconds. The research has a strong application in the development of next-generation bio-inspired solar cells and the investigation of crop failure under drought stress or conditions of high solar irradiation.\nDevelopment of new experimental approaches to probe the molecular dynamics of single biological molecules in real time in environments that mimic the natural environments to an increasingly better extent. The ultimate goal is to develop in vivo nano-spectroscopy. The techniques are currently applied on natural light-harvesting complexes and will eventually involve various bio-medical applications. The approach is from two directions:\na) Investigating the spectroscopic properties of freely diffusing macromolecules by combining single particle tracking with other conventional single molecule spectroscopy techniques.\nb) Developing novel sub-diffraction-limited spectroscopy techniques.\nThe research is conducted in collaboration with various prestigious national and international groups and participation will offer the opportunity to visit some of these groups.\nLaser coherent control of natural and artificial light-harvesting complexes. The primary goal is to develop strategies for controlling excitation energy transfer.\nExamining molecular mechanisms of photoprotection in desiccation tolerant plants.\nDeveloping photoluminescence-excitation spectroscopy to investigate molecular mechanisms of photoprotection in single complexes and small ensembles of the main plant light-harvesting complex and plant Photosystem II supercomplexes.\nInvestigating single-molecule properties of light-harvesting complexes in environments that strongly reflect their natural environment. The first major application will be on a better understanding of molecular mechanisms of photoprotection.\nInvestigating structure-function relationships of solubilised light-harvesting complexes by combining single-particle tracking with other conventional single-molecule techniques.\nDeveloping optical nanoantennas, a strongly emerging technology with a promising application in nano-spectroscopy.\nInterests and Experiences\nA strong background in Physics or Physical Chemistry is strongly beneficial. Applicants with a different background may also be considered, but this needs to be strongly motivated.\nSome experience with lasers and/or chemistry is favourable but not obligatory.\nComputer programming is a requirement for most of the projects.\nApart from the experimental approach involving spectroscopy,the underlying physics of most projects strongly overlaps with condensed matter physics and semiconductor physics. Some experience in these fields is therefore favourable but not obligatory.\nCandidates are to have an inquisitive and eager spirit to discover exciting physics.", "domain": "chemistry", "round": 3} +{"url": "http://www.miasmbs.org/author/admin-2-2/", "date": "2018-03-18T18:58:52Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-13/segments/1521257645943.23/warc/CC-MAIN-20180318184945-20180318204945-00009.warc.gz", "language_score": 0.9575290083885193, "token_count": 871, "dump": "CC-MAIN-2018-13", "global_id": "webtext-fineweb__CC-MAIN-2018-13__0__151619410", "lang": "en", "text": "Dental amalgam or silver cavity filling is a common material that is used to fill cavities. It is made from a combination of metals, such as silver, mercury, tin, and copper. There have been some concerns about the use of amalgam over the years because it contains mercury and other metals. As you continue reading this article, you will learn all about dental amalgams and begin to understand why some people and dentists still use the teeth filling option.\nDentists have been using dental amalgams for more than 150 years because it lasts for a long time and it is also less expensive compared to other cavity-filling materials, such as gold fillings and tooth-colored composites. Because of its durability, it is often considered by dentists as the best choice for large cavities that occur in the back teeth where a lot of force is used for chewing.\nAmalgam is useful in areas that are difficult to keep dry during the placement procedure, such as the gum line because it hardens quickly. It takes less time to place compared to tooth-colored fillings. It is also an effective material for special needs people and children who may find it difficult to stay still during treatment.\nThe biggest disadvantage of amalgam is that its fillings are not natural looking, especially when the filling is in the front area of the mouth. It may be visible when you smile, laugh, or speak. There is also more tooth structure that is removed while preparing to place the amalgam filling compared to other types of fillings.\nAre Dental Amalgam Fillings Safe?\nYes, it is safe and is a commonly used dental material. Most people wonder about its mercury content. When mercury is combined with other materials, it forms a stable and safe material. Rest assured that credible scientific studies have backed it up and affirmed the safety of the use of dental amalgam.\nOrganizations, such as the American Dental Association, US Centers for Disease Control and Prevention, World Health Organization, and US Food and Drug Administration all agree that based on all extensive scientific evidence that dental amalgam is safe and a very effective cavity-filling material. Even the American Academy of Pediatrics, Alzheimer’s Association, National Multiple Sclerosis Society and Autism Society of America also say that the use of amalgam as cavity fillers poses no health risk.\nDifferent Types of Mercury\nMethylmercury is the mercury found in water that builds up in fish, which lead to health problems if ingested too much. Do not worry; this is not the same type of mercury that is used in amalgam fillings. Amalgam contains elemental mercury, which releases low mercury levels in the form of a vapor that can be absorbed and inhaled by the lungs. Several research studies have found that any amount of mercury released from amalgam in the mouth is very low. The FDA said amalgams are safe for adults and children that are 6 years old and above.\nIf you think you may have a sensitivity or allergy to mercury or any of the other metals that are in dental amalgam, it is recommended that you discuss treatment options with your dentist. Only high levels of mercury vapor exposure are associated with adverse effects in the kidneys and the brain. Those who eat a lot of seafood and are exposed to mercury through their jobs may want to avoid amalgam. Your dentist’s foremost priority is your safety and health. So it is highly recommended that you discuss all of your dental filling options with your dentist first.\nAmalgam Filling Replacement\nAmalgam fillings should be replaced once they are broken, worn, and especially when there is decay found beneath the filling. If you have good amalgam fillings and want to replace them with a more natural filling, it is highly suggested that you keep the amalgam filling. Removing good amalgam may result in unnecessary loss of healthy tooth parts and it can release more mercury.\nPrevention is better than cure and it is the best medicine for cavities. Decrease the risk of cavities and dental diseases by brushing your teeth twice a day, flossing daily, eating a well-balanced diet, and visiting your dentist regularly. Keep your overall oral health always in check and visit your dentist at least twice a year.", "domain": "chemistry", "round": 3} +{"url": "https://iris.unipv.it/handle/11571/108734", "date": "2022-11-27T09:01:47Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-49/segments/1669446710218.49/warc/CC-MAIN-20221127073607-20221127103607-00773.warc.gz", "language_score": 0.9053086638450623, "token_count": 285, "dump": "CC-MAIN-2022-49", "global_id": "webtext-fineweb__CC-MAIN-2022-49__0__150265834", "lang": "en", "text": "To calculate the kinetic parameters of thiamine monophosphate transport across the rat blood-brain barrier in vivo, different doses of a [35S]thiamine monophosphate preparation with a specific activity of 14.8 mCi.mmol-1 were injected in the femoral vein and the radioactivity was measured in arterial femoral blood and in the cerebellum, cerebral cortex, pons, and medulla 20 s after the injection. This short experimental time was used to prevent thiamine monophosphate hydrolysis. Thiamine monophosphate was transported into the nervous tissue by a saturable mechanism. The maximal transport rate (Jmax) and the half-saturation concentration (Km) equaled 27-39 pmol.g-1.min-1 and 2.6-4.8 microM, respectively. When compared with that of thiamine, thiamine monophosphate transport seemed to be characterized by a lower affinity and a lower maximal influx rate. At physiological plasma concentrations, thiamine monophosphate transport rate ranged from 2.06 to 4.90 pmol.g-1.min-1, thus representing a significant component of thiamine supply to nervous tissue.\nFile in questo prodotto:\nNon ci sono file associati a questo prodotto.", "domain": "chemistry", "round": 3} +{"url": "https://19january2021snapshot.epa.gov/hfstudy/retrospective-case-study-southwestern-pennsylvania_.html", "date": "2023-06-02T20:02:06Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-23/segments/1685224648850.88/warc/CC-MAIN-20230602172755-20230602202755-00691.warc.gz", "language_score": 0.9387739896774292, "token_count": 337, "dump": "CC-MAIN-2023-23", "global_id": "webtext-fineweb__CC-MAIN-2023-23__0__49798405", "lang": "en", "text": "Retrospective Case Study in Southwestern Pennsylvania\nCase Study Background\nEPA conducted a retrospective case study in southwestern Pennsylvania to investigate reported instances of contaminated drinking water resources in areas where hydraulic fracturing activities occurred. This case study provided valuable insight into vulnerabilities and potential pathways for impacts to drinking water resources from hydraulic fracturing activities such as: surface activities (including impoundments, and associated spills), and gas migration.\n- Report: Retrospective Case Study in Southwestern Pennsylvania (PDF)\n- Fact Sheet: Southwestern Pennsylvania Retrospective Case Study\n- EPA found increased levels of chloride in ground water at locations near an impoundment site which contained hydraulic fracturing wastewaters and drilling waste. The chloride contamination likely originates from the impoundment site based on multiple lines of evidence.\n- Background data showed that methane is naturally occurring in this area and was detected in 24% of the samples collected from domestic wells. The isotopic signature of the methane present in domestic wells was not similar to that of gas produced from the shale being hydraulically fractured.\nState Activities at the Case Study Location\nPennsylvania’s Department of Environmental Protection has taken a multitude of steps to protect drinking water resources in the case study area, including issuing fines, working with the company to close the impoundment, overseeing the replacement of water supply wells, monitoring, and issuing notices of violations.\nEPA completed three rounds of water sampling from July 2011 to May 2013. Water samples were collected from domestic wells, springs, and surface water where homeowners expressed concerns regarding potential adverse impacts on their well water and possible association with drilling or processes related to hydraulic fracturing.", "domain": "chemistry", "round": 3} +{"url": "http://labome.ru/expert/the/leiden/overkleeft/herman-s-overkleeft-1750270.html", "date": "2018-12-11T05:33:52Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-51/segments/1544376823565.27/warc/CC-MAIN-20181211040413-20181211061913-00395.warc.gz", "language_score": 0.702812671661377, "token_count": 1001, "dump": "CC-MAIN-2018-51", "global_id": "webtext-fineweb__CC-MAIN-2018-51__0__99096143", "lang": "en", "text": "Herman S Overkleeft\nAffiliation: Leiden University\nCountry: The Netherlands\nJiang J, Kallemeijn W, Wright D, van den Nieuwendijk A, Rohde V, Folch E, et al\n. In vitro and in vivo comparative and competitive activity-based protein profiling of GH29 ?-l-fucosidases. Chem Sci. 2015;6:2782-false pubmed publisher\n..Competitive activity-based protein profiling identified l-fuconojirimycin as the single GH29 ?-l-fucosidase inhibitor from eight configurational isomers. ..\nStolze S, Liu N, Wijdeven R, Tuin A, van den Nieuwendijk A, Florea B, et al\n. Photo-crosslinking of clinically relevant kinases using H89-derived photo-affinity probes. Mol Biosyst. 2016;12:1809-17 pubmed publisher\n..A labelling protocol was established for recombinant kinases and more complex protein mixtures using gel-based techniques. We also show that the probes act in a competitive manner with other kinase inhibitors. ..\nJiang J, Beenakker T, Kallemeijn W, van der Marel G, van den Elst H, Codée J, et al\n. Comparing Cyclophellitol N-Alkyl and N-Acyl Cyclophellitol Aziridines as Activity-Based Glycosidase Probes. Chemistry. 2015;21:10861-9 pubmed publisher\n..Alkyl aziridines can therefore be an attractive alternative in retaining glycosidase ABP design, but in targeting a new retaining glycosidase both N-alkyl and N-acyl aziridines are best considered at the onset of a new study. ..\nLi K, Jiang J, Witte M, Kallemeijn W, Donker Koopman W, Boot R, et al\n. Exploring functional cyclophellitol analogues as human retaining beta-glucosidase inhibitors. Org Biomol Chem. 2014;12:7786-91 pubmed publisher\nKallemeijn W, Witte M, Voorn Brouwer T, Walvoort M, Li K, Codée J, et al\n. A sensitive gel-based method combining distinct cyclophellitol-based probes for the identification of acid/base residues in human retaining β-glucosidases. J Biol Chem. 2014;289:35351-62 pubmed publisher\n..The described method is highly sensitive, requiring only femtomoles (nanograms) of ABP-labeled enzymes. ..\nOuairy C, Ferraz M, Boot R, Baggelaar M, Van Der Stelt M, Appelman M, et al\n. Development of an acid ceramidase activity-based probe. Chem Commun (Camb). 2015;51:6161-3 pubmed publisher\n..Deficiency in acid ceramidase is the molecular basis of Farber disease. Here we report the synthesis and characterization of an activity-based acid ceramidase probe. ..\nLiu N, Hoogendoorn S, van de Kar B, Kaptein A, Barf T, Driessen C, et al\n. Direct and two-step bioorthogonal probes for Bruton's tyrosine kinase based on ibrutinib: a comparative study. Org Biomol Chem. 2015;13:5147-57 pubmed publisher\n..The work described here complements this existing methodology and pertains a comparative study on the efficacy of direct and two-step bioorthogonal ABPP of BTK. ..\nvan den Berg R, van Rijssel E, Ferraz M, Houben J, Strijland A, Donker Koopman W, et al\n. Synthesis and Evaluation of Hybrid Structures Composed of Two Glucosylceramide Synthase Inhibitors. ChemMedChem. 2015;10:2042-62 pubmed publisher\nde Bruin G, Xin B, Kraus M, Van Der Stelt M, van der Marel G, Kisselev A, et al\n. A Set of Activity-Based Probes to Visualize Human (Immuno)proteasome Activities. Angew Chem Int Ed Engl. 2016;55:4199-203 pubmed publisher\n..Furthermore, we show that selective and complete inhibition of β5i and β1i is cytotoxic to primary cells from acute lymphocytic leukemia (ALL) patients. ..", "domain": "chemistry", "round": 3} +{"url": "http://www.sciencepublishinggroup.com/journal/paperinfo?journalid=127&doi=10.11648/j.ajop.20200801.12", "date": "2020-08-03T21:33:15Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-34/segments/1596439735833.83/warc/CC-MAIN-20200803195435-20200803225435-00419.warc.gz", "language_score": 0.6918410062789917, "token_count": 10822, "dump": "CC-MAIN-2020-34", "global_id": "webtext-fineweb__CC-MAIN-2020-34__0__138524469", "lang": "en", "text": "Many different photovoltaic technologies are being developed for better solar energy conversion. Until now, crystalline Si solar cell represents the dominant photovoltaic technology with a market share of more than 94% with an efficiency between (15%-20%). Organic-inorganic halide Perovskite Solar Cell (PSC) has emerged as the most promising candidate for the next generation high-efficiency solar cell technology that attracted interest from researchers around the world due to their high efficiency of more than 24.% in a short period from (2008-2019) and low fabrication cost. In this paper, we designed a lead-based PSC model with a cell structure of Glass/FTO/TiO2/CH3NH3PBI3/Spiro-OMeTAD/(Au, Ag, Al, Cu, Cr, Cu-graphite alloy, and Pt) and analyzed the structure with different contact materials using Solar Cell Capacitance Simulator (SCAPS-1D) which is well adopted by many researchers to study and analyze the hybrid solar cell. Using the software allows researchers to inexpensively and promptly, the effect of the absorber and the contact materials on the performance of the proposed solar cell model. We also studied the bandgap of the active layer, defect density, thickness, operating temperature, and the fabrication method of the model. Furthermore, the adoption of multibeam multi-target MAPLE and PLD or with acronym MBMT-MAPLE/PLD techniques as a new fabrication method in our simulation program mentioned above. A promising result was achieved. Efficiencies of 27.25%, 26.52%, 18.90%, 25.66%, 22.77%, 27.25%, and 27.25% were obtained for the devices with Au, Ag, Al, Cu, Cr, Pt, and Cu-graphite alloy, respectively. The effect of the work function on the back contact has a significant influence over the FF and efficiency.\nSimulation and Analysis Method of Different Back Metals Contact of CH3NH3PbI3 Perovskite Solar Cell Along with Electron Transport Layer TiO2 Using MBMT-MAPLE/PLD, American Journal of Optics and Photonics.\nVol. 8, No. 1,\n2020, pp. 6-26.\nK. P. Bhandari and R. J. Ellingson, “An Overview of Hybrid Organic-Inorganic Metal Halide Perovskite Solar Cells,” A Comprehensive Guide to Solar Energy Systems, pp. 233–254, 2018.\nResources.solarbusinesshub.com, “Global Market Outlook for Solar Power 2016-2020 - Solar Business Hub,” Resources, Jul-2016. [Online]. Available: https://resources.solarbusinesshub.com/solar-industry-reports/item/global-market-outlook-for-solar-power-2016-2020. [Accessed: 28-Jan-2020].\nK. P. Bhandari, J. M. Collier, R. J. Ellingson, and D. S. Apul, “Energy payback time (EPBT) and energy return on energy invested (EROI) of solar photovoltaic systems: A systematic review and meta-analysis,” Renewable and Sustainable Energy Reviews, vol. 47, pp. 133–141, 2015.\nZ. Song, C. L. Mcelvany, A. B. Phillips, I. Celik, P. W. Krantz, S. C. Watthage, G. K. Liyanage, D. Apul, and M. J. Heben, “A techno-economic analysis of perovskite solar module manufacturing with low-cost materials and techniques,” Energy & Environmental Science, vol. 10, no. 6, pp. 1297–1305, 2017.\nS. K. Wallace, D. B. Mitzi, and A. Walsh, “The Steady Rise of Kesterite Solar Cells,” ACS Energy Letters, vol. 2, no. 4, pp. 776–779, 2017.\nW. S. Yang, J. H. Noh, N. J. Jeon, Y. C. Kim, S. Ryu, J. Seo, and S. I. Seok, “High-performance photovoltaic perovskite layers fabricated through intramolecular exchange,” Science, vol. 348, no. 6240, pp. 1234–1237, 2015.\nC.-H. Chiang, M. K. Nazeeruddin, M. Grätzel, and C.-G. Wu, “The synergistic effect of H2O and DMF towards stable and 20% efficiency inverted perovskite solar cells,” Energy & Environmental Science, vol. 10, no. 3, pp. 808–817, 2017.\nH. Tan, A. Jain, O. Voznyy, X. Lan, F. P. G. D. Arquer, J. Z. Fan, R. Quintero-Bermudez, M. Yuan, B. Zhang, Y. Zhao, F. Fan, P. Li, L. N. Quan, Y. Zhao, Z.-H. Lu, Z. Yang, S. Hoogland, and E. H. Sargent, “Efficient and stable solution-processed planar perovskite solar cells via contact passivation,” Science, vol. 355, no. 6326, pp. 722–726, 2017.\n“Contributed Papers in Specimen Mineralogy: 38th Rochester Mineralogical Symposium: Part 1,” Rocks & Minerals, vol. 87, no. 2, pp. 171–174, 2012.\nD. B. Mitzi, “ChemInform Abstract: Synthesis, Crystal Structure, and Optical and Thermal Properties of (C4H9NH3)2MI4 (M. Ge, Sn, Pb).,” ChemInform, vol. 27, no. 26, 2010.\nD. B. Mitzi, M. T. Prikas, and K. Chondroudis, “Thin Film Deposition of Organic−Inorganic Hybrid Materials Using a Single Source Thermal Ablation Technique,” Chemistry of Materials, vol. 11, no. 3, pp. 542–544, 1999.\nD. B. Mitzi, C. D. Dimitrakopoulos, and L. L. Kosbar, “Structurally Tailored Organic−Inorganic Perovskites: Optical Properties and Solution-Processed Channel Materials for Thin-Film Transistors,” Chemistry of Materials, vol. 13, no. 10, pp. 3728–3740, 2001.\nK. Chondroudis and D. B. Mitzi, “Electroluminescence from an Organic−Inorganic Perovskite Incorporating a Quaterthiophene Dye within Lead Halide Perovskite Layers,” Chemistry of Materials, vol. 11, no. 11, pp. 3028–3030, 1999.\nJ. Ribierre, T. Aoyama, T. Muto, and P. André, “Hybrid organic-inorganic liquid bistable memory devices,” Organic Electronics, vol. 12, no. 11, pp. 1800–1805, 2011.\nD. Wang, M. Wright, N. K. Elumalai, and A. Uddin, “Stability of perovskite solar cells,” Solar Energy Materials and Solar Cells, vol. 147, pp. 255–275, 2016.\nA. Husainat, W. Ali, P. Cofie, J. Attia, and J. Fuller, “Simulation and Analysis of Methylammonium Lead Iodide (CH3NH3PbI3) Perovskite Solar Cell with Au Contact Using SCAPS 1D Simulator,” American Journal of Optics and Photonics, vol. 7, no. 2, p. 33, 2019.\nA. Kojima, K. Teshima, Y. Shirai, and T. Miyasaka, “Organometal Halide Perovskites as Visible-Light Sensitizers for Photovoltaic Cells,” Journal of the American Chemical Society, vol. 131, no. 17, pp. 6050–6051, 2009.\nJ.-H. Im, C.-R. Lee, J.-W. Lee, S.-W. Park, and N.-G. Park, “6.5% efficient perovskite quantum-dot-sensitized solar cell,” Nanoscale, vol. 3, no. 10, p. 4088, 2011.\nH.-S. Kim, C.-R. Lee, J.-H. Im, K.-B. Lee, T. Moehl, A. Marchioro, S.-J. Moon, R. Humphry-Baker, J.-H. Yum, J. E. Moser, M. Grätzel, and N.-G. Park, “Lead Iodide Perovskite Sensitized All-Solid-State Submicron Thin Film Mesoscopic Solar Cell with Efficiency Exceeding 9%,” Scientific Reports, vol. 2, no. 1, 2012.\nM. M. Lee, J. Teuscher, T. Miyasaka, T. N. Murakami, and H. J. Snaith, “Efficient Hybrid Solar Cells Based on Meso-Superstructured Organometal Halide Perovskites,” Science, vol. 338, no. 6107, pp. 643–647, 2012.\n“Newcomer Juices Up the Race to Harness Sunlight,” Science, vol. 342, no. 6165, pp. 1438–1439, 2013.\nS. S. Shin, E. J. Yeom, W. S. Yang, S. Hur, M. G. Kim, J. Im, J. Seo, J. H. Noh, and S. I. Seok, “Colloidally prepared La-doped BaSnO 3 electrodes for efficient, photostable perovskite solar cells,” Science, vol. 356, no. 6334, pp. 167–171, 2017.\nA. Ummadisingu, L. Steier, J.-Y. Seo, T. Matsui, A. Abate, W. Tress, and M. Grätzel, “The effect of illumination on the formation of metal halide perovskite films,” Nature, vol. 545, no. 7653, pp. 208–212, 2017.\nJ. Burschka, N. Pellet, S.-J. Moon, R. Humphry-Baker, P. Gao, M. K. Nazeeruddin, and M. Grätzel, “Sequential deposition as a route to high-performance perovskite-sensitized solar cells,” Nature, vol. 499, no. 7458, pp. 316–319, 2013.\nD. Liu and T. L. Kelly, “Perovskite solar cells with a planar heterojunction structure prepared using room-temperature solution processing techniques,” Nature Photonics, vol. 8, no. 2, pp. 133–138, 2013.\nQ. Chen, H. Zhou, Z. Hong, S. Luo, H.-S. Duan, H.-H. Wang, Y. Liu, G. Li, and Y. Yang, “Planar Heterojunction Perovskite Solar Cells via Vapor-Assisted Solution Process,” Journal of the American Chemical Society, vol. 136, no. 2, pp. 622–625, 2013.\nM. Liu, M. B. Johnston, and H. J. Snaith, “Efficient planar heterojunction perovskite solar cells by vapour deposition,” Nature, vol. 501, no. 7467, pp. 395–398, 2013.\nC.-W. Chen, H.-W. Kang, S.-Y. Hsiao, P.-F. Yang, K.-M. Chiang, and H.-W. Lin, “Efficient and Uniform Planar-Type Perovskite Solar Cells by Simple Sequential Vacuum Deposition,” Advanced Materials, vol. 26, no. 38, pp. 6647–6652, 2014.\nW.-J. Yin, T. Shi, and Y. Yan, “Unique Properties of Halide Perovskites as Possible Origins of the Superior Solar Cell Performance,” Advanced Materials, vol. 26, no. 27, pp. 4653–4658, 2014.\nM. Solomon and A. Johnson, “New Research in Solar Cells: Urbach Tails and Open Circuit Voltage,” Elements, vol. 11, no. 1, 2015.\nS. D. Wolf, J. Holovsky, S.-J. Moon, P. Löper, B. Niesen, M. Ledinsky, F.-J. Haug, J.-H. Yum, and C. Ballif, “Organometallic Halide Perovskites: Sharp Optical Absorption Edge and Its Relation to Photovoltaic Performance,” The Journal of Physical Chemistry Letters, vol. 5, no. 6, pp. 1035–1039, 2014.\nG. E. Eperon, S. D. Stranks, C. Menelaou, M. B. Johnston, L. M. Herz, and H. J. Snaith, “Formamidinium lead trihalide: a broadly tunable perovskite for efficient planar heterojunction solar cells,” Energy & Environmental Science, vol. 7, no. 3, p. 982, 2014.\nY. Li, B. Ding, Q.-Q. Chu, G.-J. Yang, M. Wang, C.-X. Li, and C.-J. Li, “Ultra-high open-circuit voltage of perovskite solar cells induced by nucleation thermodynamics on rough substrates,” Scientific Reports, vol. 7, no. 1, 2017.\nW. Tress, N. Marinova, O. Inganäs, M. K. Nazeeruddin, S. M. Zakeeruddin, and M. Graetzel, “Predicting the Open-Circuit Voltage of CH3NH3PbI3 Perovskite Solar Cells Using Electroluminescence and Photovoltaic Quantum Efficiency Spectra: the Role of Radiative and Non-Radiative Recombination,” Advanced Energy Materials, vol. 5, no. 3, p. 1400812, 2014.\nC. Wehrenfennig, G. E. Eperon, M. B. Johnston, H. J. Snaith, and L. M. Herz, “High Charge Carrier Mobilities and Lifetimes in Organolead Trihalide Perovskites,” Advanced Materials, vol. 26, no. 10, pp. 1584–1589, 2013.\nT. Leijtens, S. D. Stranks, G. E. Eperon, R. Lindblad, E. M. J. Johansson, I. J. Mcpherson, H. Rensmo, J. M. Ball, M. M. Lee, and H. J. Snaith, “Electronic Properties of Meso-Superstructure and Planar Organometal Halide Perovskite Films: Charge Trapping, Photodoping, and Carrier Mobility,” ACS Nano, vol. 8, no. 7, pp. 7147–7155, 2014.\nD. Shi, V. Adinolfi, R. Comin, M. Yuan, E. Alarousu, A. Buin, Y. Chen, S. Hoogland, A. Rothenberger, K. Katsiev, Y. Losovyj, X. Zhang, P. A. Dowben, O. F. Mohammed, E. 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[Accessed: 29-Jan-2020].", "domain": "chemistry", "round": 3} +{"url": "http://ieeexplore.ieee.org/xpl/articleDetails.jsp?reload=true&arnumber=4550221&contentType=Conference+Publications", "date": "2015-11-28T23:58:09Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2015-48/segments/1448398454553.89/warc/CC-MAIN-20151124205414-00271-ip-10-71-132-137.ec2.internal.warc.gz", "language_score": 0.9334082007408142, "token_count": 510, "dump": "CC-MAIN-2015-48", "global_id": "webtext-fineweb__CC-MAIN-2015-48__0__93340686", "lang": "en", "text": "Skip to Main Content\nIn this study, flip-chip packaging method was using gold stud bump on chip side and SnAgCu, lead free solder pad on organic substrate. Also capillary underfill enhanced the mechanical properties of gold-solder bump joint. This method was set up to the mass production of the high speed DRAM (Dynamic Random Access Memory) flip-chip package. This kind of gold stud flip-chip package has some weak points on mass production and package reliability. To discover the weak point on mass production and reliability of package, the microstructure of the flip-chip gold-stud and solder bump joints were studied. Gold-tin intermetallics were formed on whole bump joint body after flip-chip packaged as many researchers reported. The delta, epsiv, and eta-gold-tin intermetallic compounds formed sequentially from the gold stud bump. Reflow, high temperature and high humidity (85degC/85%), and pressure cooker test (PCT) method were used to study the reliability of this gold stud and solder flip-chip package. From this reliability test, the coverage of solder to the gold bump was very important point of the reliability issue. In flip-chip bonding process, the variations of bonding parameter affected the length of the gold stud and solder joint. In case of the solder covered the whole gold bump body, this package was failed perfectly in PCT test. From the warpage data of the package after reliability tested and through the stress analysis, the gold-solder intermetallic and humidity made the crack initiator in the root area of gold stud bump. Thermal simulation was performed to prevent this solder coverage over the whole body of gold stud bumps. Also, combinations of underfill and solder resist material on the substrate affected the PCT test results. We chosen 3 types of underfill from A company and 4 types of solder resist material from B company. 2 mm by 2 mm silicon nitride test coupon attached with various underfill on substrate processed with various solder resist material. Those test - vehicles were tested with shear test after 240 hrs PCT. Underfill and solder resist material had a common base polymer, epoxy but test results showed different results from different combinations. Substrate makers chosen solder resist materials which had good development characteristics in their patterning process because the flip-chip package had very complicated input/outputs on it's surface. But it is very important to consider the compatibilities of processing and reliability aspects between underfill and solder resist.", "domain": "chemistry", "round": 3} +{"url": "https://btkinhibitor.com/2023/10/10/19069/", "date": "2023-12-01T12:04:22Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100287.49/warc/CC-MAIN-20231201120231-20231201150231-00481.warc.gz", "language_score": 0.9693346619606018, "token_count": 989, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__313517465", "lang": "en", "text": "Sing HA-cyclin A resulted in a important improve of acetylated cyclin A (Fig. 2F). HDAC3 Regulates Cyclin A Stability–We studied whether the enhanced acetylation observed in HDAC3 knocked down (HDAC3-KD) cells induces cyclin A degradation via proteasome. To this objective, cyclin A Phospholipase A Inhibitor medchemexpress levels have been determined by WB in HDAC3-KD cells in the presence or absence of the proteasome inhibitor ALLN. As shown in Fig. 3A, ALLN treatment inhibits cyclin A degradation in HDAC3-KD cells. We also determined the half-life of cyclin A in these cells. For these experiments HDAC3-KD cells had been synchronized at G1/S, by a double thymidine blockade (due to the fact at this stage cyclin A is highly stable). Then, cells have been released from the block, and cycloheximide was added to the culture. Lastly, cells at differ-ent times immediately after cycloheximide addition were collected and subjected to WB with anti-HDAC3, anti-cyclin A, and anti-actin, the latter used as a loading handle. Results clearly revealed that HDAC3-KD cells presented a considerably far more lowered cyclin A half-life (t1/2 4 h) than manage cells (t1/2 six h) (Fig. 3B). We subsequently studied the impact of HDAC3 knock down around the stability of a cyclin A mutant in which 4 lysines (K54, K68, K95, and K112) have been substituted for arginines. It has been previously shown that this cyclin A mutant (cyclin A-4R) can’t be acetylated (26). Hence, HDAC3-KD cells had been transfected with Flag-cyclin A-WT or Flag-cyclin A-4R. Then, cyclin A levels were determined by WB. As shown in Fig. 3C in HDAC3-KD cells the levels of cyclin A-WT have been clearly lowered whereas those of your mutant cyclin A-4R have been not. Moreover, the half-life of cyclin A-4R in HDAC3-KD cells wasVOLUME 288 ?Number 29 ?JULY 19,21100 JOURNAL OF BIOLOGICAL CHEMISTRYHDAC3 Deacetylates Cyclin AFIGURE four. HDAC3 MMP-1 Inhibitor supplier interacts with cyclin A at G1/S and G2/M phases of the cell cycle and is degraded at metaphase. A, HeLa cells had been transfected with HA-cyclin A and Flag-HDAC3. Then, cells had been synchronized at different stages from the cell cycle as described below “Experimental Procedures,” and levels of HDAC3 and cyclin A were determined by WB (left panel). Cell extracts had been subjected to IP with anti-Flag and the quantity of HDAC3 and cyclin A inside the immunoprecipitates was determined by WB. B, HeLa cells were transfected with Flag-HDAC3 and subsequently synchronized at G1/S and G2/M as described beneath “Experimental Procedures.” Then, the levels of Flag-HDAC3 in asynchronously growing and synchronized cells have been determined by WB with anti-Flag (left panel). Cell extracts were subjected to IP with anti-Flag or IgG (made use of as a manage). The immunoprecipitates were utilized as a source of HDAC3 and were subsequently incubated for 30 min with acetylated histones that had been obtained as described beneath “Experimental Procedures.” Then, the total levels of histone H4 and the levels of acetylated histone H4 were determined with anti-histones and anti-acetyl lysine, respectively. C, HeLa cells were transfected with Flag-HDAC3 and subsequently synchronized at metaphase as described below “Experimental Procedures.” Asynchronously increasing and synchronized cells have been cultured within the presence or absence in the proteasome inhibitor ALLN for 16 h. Then, the levels of HDAC3, phosphorylated histone H3 and actin were determined by WB. D, HeLa cells were transfected with Flag-HDAC3 and treated with 20 M roscovitine overnight. Then, the levels of Flag-HDAC3 had been analyzed by WB in treated (ROS) versus untreated (C) ce.", "domain": "chemistry", "round": 3} +{"url": "http://scialert.net/abstract/index.php?doi=ajpp.2012.120.134", "date": "2013-12-05T08:20:27Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2013-48/segments/1386163042403/warc/CC-MAIN-20131204131722-00010-ip-10-33-133-15.ec2.internal.warc.gz", "language_score": 0.9286323189735413, "token_count": 384, "dump": "CC-MAIN-2013-48", "global_id": "webtext-fineweb__CC-MAIN-2013-48__0__176437523", "lang": "en", "text": "Abstract: In vitro cultures subjected to salt-stress have been shown to exhibit unique characteristics that are useful for identifying stress status. The objective of this study was to investigate the physiological responses of date palm, Phoenix dactylifera L. cv. Barhee, callus to salinity stress. Callus were cultured on MS medium supplemented with NaCl, KCl, or CaCl2 at 0.8 MPa (-8 bars) equivalent osmotic potential concentrations. The exposure to salt stress resulted in reduction in callus dry weight as compared to the control. Sodium chloride caused the highest reduction in dry weight followed by KCl then CaCl2. In general, callus water content decreased in response to extending exposure durations regardless of the salt type used. Increasing the exposure duration up to 6 days caused increase in proline content compared to the control. Extending the exposure duration of KCl and CaCl2 to 9 days caused reduction in proline content, due to cell death as indicated by culture browning. Exposure to NaCl initially caused increase in Na+ content but at the ninth day, significant reduction in Na+ content was observed. Increasing salt exposure duration caused significant increase in K+ content as compared to the control, up to 3 days of exposure after which the content decreased but remained higher than the control cultures. The Na+/K+ ratio was also significantly affected by the salt type and the exposure duration. This study has enhanced the understanding of the influence of salinity on physiological aspects of date palm cell cultures.\nAbdulaziz M. Al-Bahrany and Jameel M. Al-Khayri, 2012. In vitro Responses of Date Palm Cell Suspensions under Osmotic Stress Induced by Sodium, Potassium and Calcium Salts at Different Exposure Durations. American Journal of Plant Physiology, 7: 120-134.", "domain": "chemistry", "round": 3} +{"url": "https://epjwoc.epj.org/articles/epjconf/abs/2017/22/epjconf_icrs2017_03009/epjconf_icrs2017_03009.html", "date": "2021-03-08T22:35:45Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-10/segments/1614178385529.97/warc/CC-MAIN-20210308205020-20210308235020-00221.warc.gz", "language_score": 0.8771641850471497, "token_count": 278, "dump": "CC-MAIN-2021-10", "global_id": "webtext-fineweb__CC-MAIN-2021-10__0__198829448", "lang": "en", "text": "A Study on the Establishment of Radiation Dose Estimation Procedure for Accumulated Radioactive Ions for RAON ISOL System\n1 Department of Nuclear Engineering, 04763 Hanyang University, Korea\n2 Facility Construction & Infrastructure Division, Rare Isotope Science Project, 34047 Institute for Basic Science, Korea\na Corresponding author: firstname.lastname@example.org\nPublished online: 25 September 2017\nFor purposes of various experiments, RAON heavy ion accelerator facility has been designed in Korea. ISOL is one system of RAON accelerators to generate and separate rare isotopes. Radioactive ions generated from target-proton reactions are separated and accumulated at separation devices. The accumulated isotopes release the gamma radiations; therefore, the radiation safety must be clearly estimated. In this study, a process to evaluate radiations from the accumulated ions was proposed by modifying FISPACT code. The proposed process was validated by comparing a solution of single element decay problem. Using the process, a preliminary study for radiation doses were performed in a virtual separation devise.\n© The Authors, published by EDP Sciences, 2017\nThis is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.", "domain": "chemistry", "round": 3} +{"url": "http://kdo.garciniacambogiareport.us/testosterone-propionate-and-dianabol-cycle.html", "date": "2018-08-15T16:33:35Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-34/segments/1534221210243.28/warc/CC-MAIN-20180815161419-20180815181419-00401.warc.gz", "language_score": 0.9363012909889221, "token_count": 400, "dump": "CC-MAIN-2018-34", "global_id": "webtext-fineweb__CC-MAIN-2018-34__0__42835183", "lang": "en", "text": "Because the ultimate goal of a steroid cycle is to increase strength and muscle size, the associated spike in estrogen which accompanies steroids such as Testosterone is considered undesirable. In order to disassociate the two effects, two classes of drug are used. Medications such as Nolvadex or Clomid target the estrogen receptors. They make it more difficult for the estrogen to exert it’s influence within the body thus allowing the testosterone to act more freely. The second class is aromatase inhibitors such as Femara. They target the aromatase enzyme itself in order to prevent the production of estrogen in the first place. Sometimes, it’s not always clear which option you should go with or even what the differences are between the two. Lets clear that up a little.\nWhile we are familiar with the Propionate ester the remaining three esters that create Sustanon-250 are almost always found as part of a mixture or compounded anabolic androgenic steroid .\nDeveloped by Organon, the original idea behind Sustanon-250 was to provide a testosterone form well-suited for hormone replacement therapy that would only needed to be administered once every few weeks and for all intense purposes the idea was a success. For the performance enhancing athlete Sustanon-250 can be a fine choice but the idea of injecting only once or twice a month is not applicable here. As a performance enhancer this testosterone like all forms will need to be administered on a more frequent basis. This mixture carries with it two fast, short esters, Propionate and Pheylpropionate, a longer more moderate ester Isocaproate and the very slow and long Decanoate ester. In order to keep testosterone levels stable and at their peak most athletes will inject Sustanon-250 at a minimum of every 3 days and more commonly every other day for optimal results.\nFor more info see: Sustanon-250", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/mcm10-antibody-ab3733.html", "date": "2020-08-15T05:16:42Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-34/segments/1596439740679.96/warc/CC-MAIN-20200815035250-20200815065250-00071.warc.gz", "language_score": 0.7972942590713501, "token_count": 839, "dump": "CC-MAIN-2020-34", "global_id": "webtext-fineweb__CC-MAIN-2020-34__0__183374493", "lang": "en", "text": "Key features and details\n- Rabbit polyclonal to MCM10\n- Suitable for: IP, WB\n- Reacts with: Human\n- Isotype: IgG\nProduct nameAnti-MCM10 antibody\nSee all MCM10 primary antibodies\nDescriptionRabbit polyclonal to MCM10\nTested applicationsSuitable for: IP, WBmore details\nSpecies reactivityReacts with: Human\nPredicted to work with: Mouse, Chimpanzee, Rhesus monkey, OrangutanDoes not react with: Xenopus laevis, Drosophila melanogaster\nSynthetic peptide (Human) - which represented a portion of Minichromosome Maintenance Deficient 10 encoded within exon 14.\n- HeLa cell lysate.\nStorage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.\nStorage bufferPreservative: 0.1% Sodium azide\nConstituents: 0.021% PBS, 1.764% Sodium citrate, 1.815% Tris\nConcentration information loading...\nPurityImmunogen affinity purified\nOur Abpromise guarantee covers the use of ab3733 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\n|IP||Use a concentration of 1 - 4 µg/ml.|\n|WB||1/1000 - 1/5000. Detects a band of approximately 110 kDa (predicted molecular weight: 110 kDa).|\nFunctionActs as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication. Additionally, plays a role in preventing DNA damage during replication.\nSequence similaritiesBelongs to the MCM10 family.\nDevelopmental stageExpression is cell cycle regulated. Expression increases at the G1/S-boundary. Expression decreases in late M phase, remains low during G(1) phase, and starts to accumulate at the onset of S phase.\nDomainThe zinc finger-like domain binds a zinc ion and is involved in self-association.\nmodificationsPhosphorylated upon DNA damage, probably by ATM or ATR.\nCellular localizationNucleus. Colocalizes with ORC2 in nuclei foci. Associated with chromatin in S phase. From early to mid-S phase located in discrete nuclear foci. In early S phase, several hundred foci appeared throughout the nucleus. In mid-S phase, the foci appeared at the nuclear periphery and nucleolar regions. In the late S and G phases localized to nucleoli.\n- Information by UniProt\n- CNA43 antibody\n- DNA43 antibody\n- FLJ31133 antibody\nab3733 has been referenced in 4 publications.\n- Ma Y et al. Lamin B2 binding to minichromosome maintenance complex component 7 promotes non-small cell lung carcinogenesis. Oncotarget 8:104813-104830 (2017). PubMed: 29285216\n- Liao YX et al. Silencing of RTKN2 by siRNA suppresses proliferation, and induces G1 arrest and apoptosis in human bladder cancer cells. Mol Med Rep 13:4872-8 (2016). PubMed: 27082503\n- Miotto B et al. The RBBP6/ZBTB38/MCM10 axis regulates DNA replication and common fragile site stability. Cell Rep 7:575-87 (2014). WB . PubMed: 24726359\n- Im JS et al. Assembly of the Cdc45-Mcm2-7-GINS complex in human cells requires the Ctf4/And-1, RecQL4, and Mcm10 proteins. Proc Natl Acad Sci U S A 106:15628-32 (2009). PubMed: 19805216", "domain": "chemistry", "round": 3} +{"url": "https://www.navfac.navy.mil/Divisions/Environmental/Products-and-Services/Environmental-Restoration/Mid-Atlantic/Crane-NSA/PFAS-Sampling/", "date": "2024-04-20T07:13:05Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712296817491.77/warc/CC-MAIN-20240420060257-20240420090257-00383.warc.gz", "language_score": 0.9584790468215942, "token_count": 2253, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__24095911", "lang": "en", "text": "PFAS Private Drinking Water Well Sampling\nFor information on the NSA Crane private drinking water well investigation of PFAS, please contact the NSA Crane Public Affairs Office at:\n(812) 854-3524 or firstname.lastname@example.org\nSkip to Background\nNew Update as of 26 June 2019\nAs of this date, the Navy has received preliminary test results from the sampling described in the background section below. As depicted in the chart, of the seven samples collected, PFOS/PFOA was not detected above the EPA’s Lifetime Health Advisory limit of 70 parts per trillion (ppt) or nanograms per liter (ng/L). Of the seven samples collected, six were non-detect for PFOS/PFOA and the one remaining sample result had less than 1 ppt for PFOS/PFOA. The private drinking water well owners were notified of their individual results by phone and mail.\n|NSA Crane Off-Facility Drinking Water Sampling Status as of Wednesday June 26, 2019\nInitial Parcels Requested for Sampling\nNumber of Potential Wells Identified Within Sampling Area\nPreliminary Results Received\nValidated Results Received\nPreliminary Results Received above the Lifetime Health Advisory\nValidated Results Received above the Lifetime Health Advisory\n*Original 160 parcels were identified as being located within the designated sampling area. Based on record searches, 18 private drinking water wells were identified on the 160 parcels based on database searches. Of these, 7 wells were sampled at the request of the owners.\nWhat does this mean?\nPFOS/PFOA was not detected above the EPA’s Lifetime Health Advisory in the off-facility private drinking water wells.\nThe Navy responded to potential releases of PFOS/PFOA-containing substances at two potential PFAS source areas by testing nearby (within one mile down-gradient) private drinking water wells to:\ndetermine whether wells were impacted by any PFOS/PFOA that exceeded relevant concentration standards; and\ndetermine whether expanding the area of private drinking water well testing was necessary.\nThere were no detections and only one very low detection of PFOS/PFOA in the tested off-base private drinking water wells.\nAlternate sources of drinking water are not needed.\nPer Navy Policy, the Navy was prepared to provide alternate drinking water for any affected drinking water wells above the lifetime health advisory (LHA). Since no well exceeded the LHA, alternate sources of drinking water are not needed.\nExpanding the designated sampling area is not needed at this time.\nHad the Navy detected concentrations above the EPA health advisory of PFOS/PFOA in the nearby drinking water wells, the Navy would have reevaluated the scope of private drinking water wells that it would seek to test. The levels observed (i.e., low detections below the health advisory or not detected) mean that the Navy will not expand the scope of its private drinking water well sampling footprint at this time.\nRespond to any promulgated state standards\nNavy policy is to provide alternate drinking water to any drinking water wells impacted by Navy releases of PFOS/PFOA when those drinking water wells contain concentrations above the EPA lifetime health advisory. The Navy will reevaluate whether to provide alternate drinking water in light of any promulgated state standards. Should Indiana promulgate a standard, the Navy will reevaluate whether to provide an alternate drinking water source in light of that standard.\nThe Navy is preparing to investigate the potential PFAS areas of concerns at NSA Crane beginning in Summer 2019. The process will begin after the Preliminary Assessment report is reviewed by the Indiana Department of Environmental Management.\nNaval Support Activity Crane\nNaval Support Activity (NSA) Crane is located in southwestern Indiana, approximately 70 miles southwest of Indianapolis and approximately 90 miles northeast of Evansville, Indiana and covers more than 97 square miles (62,000 acres) of heavily forested and hilly terrain. NSA Crane’s 460 acre Lake Glendora Test Facility (LGTF) is located approximately 45 miles northwest of the NSA Crane main site. NSA Crane hosts over a dozen tenants, the two largest being the Naval Surface Warfare Center (NSWC) Crane Division with its Strategic, Expeditionary and Electronic Warfare engineering and technical support missions and the Crane Army Ammunition Activity (CAAA) whose missions involve the storage, distribution, demilitarization, and production of munitions.\nAreas for PFAS Drinking Water Well Sampling\nThe Navy had requested permission to sample drinking water obtained from private wells within the designated area near NSA Crane. The Navy has developed a proactive policy to address past releases of per- and polyfluoroalkyl substances, commonly known as PFAS. These substances may be present in the soil and/or groundwater as a result of firefighter training activities at NSA Crane using aqueous film forming foam (AFFF).\nDrinking water at NSA Crane is primarily from surface water from Lake Greenwood. Two on-installation drinking water wells are present at Ammunition Burning Ground and Ordnance Training Area Building. An off-installation facility, Glendora Lake Test Facility, located approximately 30 miles north of NSA Crane, obtains water from Indiana American Water – Sullivan (PWS ID IN5277009). Drinking water samples were collected from the water treatment plant at Crane, the two drinking water wells, and drinking water for Lake Glendora Test Facility, and samples were analyzed for perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS). Although PFOA was detected in the samples, it is far below the EPA's lifetime health advisory of 70 parts per trillion (ppt) for combined PFOA and PFOS was not exceeded in any sample (AH Environmental Consultants, 2016).\nBased on information available to-date, two potential PFAS source areas have been identified (Figure 2). One potential source area is a fire station where firefighting training activities occurred. The other potential source area is a closed sanitary landfill where PFAS-containing materials may have been disposed.\nFigure 1 - Crane Location Map\nFigure 2 - Designated Sampling Area\nThis drinking water investigation focused on the potential for off-property migration of PFAS to groundwater used as drinking water from private wells. The Navy has identified private drinking water wells within the designated area, which is the initial off-property residential well sampling area, as shown on Figure 2. To ensure water is not above the EPA lifetime health advisory levels, the Navy offered this private drinking water well sampling to all residents in the sampling area. The Navy sent letters to property owners in the designated area requesting permission to sample their private drinking water wells. Furthermore, the Navy, with the support of state and federal regulatory agencies, conducted a public Open House Meeting on May 15, 2019, with subject matter experts, and offered an opportunity to sign up for sampling appointments free of charge. The Navy wants to ensure that residents are not being exposed to PFOA and/or PFAS in their drinking water from historical operations at NSA Crane at concentrations exceeding the EPA’s lifetime health advisory level.\nPer-and Polyfluoroalkyl Substances\nPFAS are manufactured chemicals that have been used since the 1950s in many household and industrial products because of their stain‐ and water‐repellant properties. Within Department of the Navy’s (DON) operations, PFAS are most commonly associated with AFFF used primarily for firefighting (including response to plane crashes, equipment testing, training, or buildings where AFFF was used in the fire suppression system). PFAS are now present virtually everywhere in the world because of the large amounts that have been manufactured and used by international consumers and industry. Once these compounds are released to the environment, they break down very slowly. PFAS are considered “emerging” contaminants, which have no Safe Drinking Water Act regulatory standards or routine water quality testing requirements. The EPA is currently studying PFAS to determine if national regulation is needed.\nThe 1996 Safe Drinking Water Act (SDWA) amendments require that once every five years EPA issues a new list of no more than 30 unregulated contaminants to be monitored by public water systems (PWSs). The EPA issued the third Unregulated Contaminant Monitoring Rule (UCMR3) in May 2012. Between 2013 and 2015, all large PWSs serving more than 10,000 people and 800 representative PWSs serving 10,000 or fewer people analyzed drinking water samples for the 30 UCMR3 compounds, which included six PFAS compounds. In May 2016, the EPA issued health advisories for two PFAS compounds, specifically PFOA and PFOS. Health advisories are not regulatory standards, but they are health‐based concentrations which offer a margin of protection for all Americans throughout their lifetime from exposure to PFOS and PFOA in drinking water. The EPA health advisory level for lifetime exposure (termed the lifetime health advisory level) is 70 parts per trillion (ppt) for PFOS and 70 ppt for PFOA. When both PFOS and PFOA are found in drinking water, the combined concentrations should not exceed 70 ppt.\nThe DON Assistant Secretary of the Navy (Energy, Installations and Environment) (ASN (EI&E)) issued a policy in 2014 requiring on-base drinking water sampling for PFOA and PFOS for bases where groundwater was used as drinking water and PFAS could have been released nearby in the past. Under the policy, drinking water sources from on-installation sources were required to sample their finished drinking water by December 2015 if they had not previously been tested under UCMR3 and if an identified or suspected PFAS release was within approximately one mile and located up-gradient to the drinking water source. In June 2016, the DON issued an additional policy that required all DON installations not previously tested under UCMR3 or the 2014 policy to test their finished drinking water regardless of the drinking water source (installation or municipal) and regardless of proximity to a potential/known PFAS release to the environment.\nIn June 2016, the DON ASN (EI&E) also issued a policy to identify and prioritize sites for investigation if drinking water resources, on- or off-installation, are thought to be vulnerable to PFAS contamination from past known or potential Navy releases of PFAS. Sites with drinking water sources within one mile and downgradient from known or potential releases of PFAS were assigned the highest priority.\nNSA Crane Drinking Water Investigation Documents", "domain": "chemistry", "round": 3} +{"url": "http://invitroscreeningblog.com/", "date": "2017-02-23T20:37:21Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-09/segments/1487501171232.43/warc/CC-MAIN-20170219104611-00592-ip-10-171-10-108.ec2.internal.warc.gz", "language_score": 0.9329351186752319, "token_count": 621, "dump": "CC-MAIN-2017-09", "global_id": "webtext-fineweb__CC-MAIN-2017-09__0__49345354", "lang": "en", "text": "We thank Mari Koivisto, Department of Biostatistics, University of Turku, Finland for help with the statistical analyses. Conflict of interest statement: AK has participated as a member in advisory boards of Pfizer, GlaxoSmithKline and Novartis and received honorarium from these. She has acted as a consultant to Crucell on vaccination immunology and been reimbursed for giving lectures by GPCR Compound Library concentration Crucell, GSK and Bayer. SHP and JMK declare no conflicts of interest. “\n“Meningitidis and sepsis caused by serogroup B meningococcus are two severe diseases that\ncontinue to cause significant mortality and . Five major pathogenic serogroups have been identified on the basis of the chemical composition of the bacterial capsule (A, B, C, Y and W135) , and . selleck chemical However, the capsular vaccine approach is not suitable for strains of serogroup B since that polysaccharide capsule\nhas a structural homology to human embryonic neural tissue . Thus, outer membrane proteins or outer membrane vesicles (OMV)-based vaccines were tested extensively in clinical trials . An alternative approach to vaccine development is based on surface-exposed proteins contained in outer membrane vesicles , and . OMV are released from the outer membrane of Gram negative bacteria. They consist of a phospholipid (PL) bilayer containing outer membrane proteins, lipopolysacchharide\n(LPS) and periplasmic constituents . These vesicles are made up of five major proteins. Besides, there is the protein NadA and, depending on the conditions of cultivation, the iron regulated proteins (IRP) , and . Furthermore, it is worth mentioning that OMV are also employed as carriers of polysaccharides in conjugated vaccines against Haemophilus influenzae and in vaccines against pneumonia and . A common antimeningococcal vaccine project against meningitis B and C had proposed a vaccine containing outer membrane vesicles (OMV) from Neisseria meningitidis B expressing iron regulated proteins (IRP) from a strain with high incidence in Brazil (N 44/89). The lipooligosaccharide (LOS endotoxin) of OMV is high others toxic. However residual LOS amounts are needed to maintain vesicle structure and adjuvate the immune response. Many studies have been carried out previously on other aspects of vaccine development, such as: the production process of N. meningitidis C , and ; the evaluation of the importance of a second serogroup B strain as vaccine component ; the obtainment of vesicles with appropriate characteristics (with IRP expression and with low level of LOS) and ; and the conjugation process of N. meningitidis C polysaccharide with N. meningitidis B OMV and . The objective of this study was to investigate the N.", "domain": "chemistry", "round": 3} +{"url": "http://dspace.mit.edu/handle/1721.1/36872", "date": "2022-01-24T14:53:15Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-05/segments/1642320304570.90/warc/CC-MAIN-20220124124654-20220124154654-00022.warc.gz", "language_score": 0.781613826751709, "token_count": 414, "dump": "CC-MAIN-2022-05", "global_id": "webtext-fineweb__CC-MAIN-2022-05__0__204298942", "lang": "en", "text": "6.152J / 3.155J Microelectronics Processing Technology, Fall 2003\nAuthor(s)Schmidt, Martin A.; O'Handley, Robert C., 1942-; Ruff, Susan\nMicroelectronics Processing Technology\nMetadataShow full item record\nIntroduces the theory and technology of integrated-circuit fabrication. Lectures and laboratory sessions on basic processing techniques such as diffusion, oxidation, epitaxy, photolithography, chemical vapor deposition, and plasma etching. Emphasis on the interrelationships between material properties, device structure, and the electrical behavior of devices. Provides background for thesis work in microelectronics or for 6.151. From the course home page: Course Description This course introduces the theory and technology of micro/nano fabrication. Lectures and laboratory sessions focus on basic processing techniques such as diffusion, oxidation, photolithography, chemical vapor deposition, and more. Through team lab assignments, students are expected to gain an understanding of these processing techniques, and how they are applied in concert to device fabrication. Students enrolled in this course have a unique opportunity to fashion and test micro/nano-devices, using modern techniques and technology.\nmicroelectronics, Microelectronics processing, integrated circuits, vacuum, chemical vapor deposition, CVD, oxidation, diffusion, implantation, lithography, soft lithography, etching, sputtering, evaporation, interconnect, metallization, crystal growth, reliability, fabrication, processing, photolithography, physical vapor deposition, MOS, MOS capacitor, microcantilever, microfluidic, 6.152J, 3.155J, 6.152, 3.155", "domain": "chemistry", "round": 3} +{"url": "http://mefim.21102.ru/radio-carbon-dating-coal-25.html", "date": "2021-01-25T07:32:18Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-04/segments/1610703565376.63/warc/CC-MAIN-20210125061144-20210125091144-00217.warc.gz", "language_score": 0.9285849332809448, "token_count": 341, "dump": "CC-MAIN-2021-04", "global_id": "webtext-fineweb__CC-MAIN-2021-04__0__254085697", "lang": "en", "text": "When granite rock hardens, it freezes radioactive elements in place.The most common radioactive element in granite is Uranium-238.You can help Amazing Discoveries reduce costs by upgrading or replacing your internet browser with one of the options below.We thank you in advance for partnering with us in this small but significant way. All methods of radioactive dating rely on three assumptions that may not necessarily be true: It is assumed that the rate of decay has remained constant over time.Evolutionists assume that the rate of cosmic bombardment of the atmosphere has always remained constant and that the rate of decay has remained constant.Scientists place great faith in this dating method, and yet more than 50% of radiocarbon dates from geological and archaeological samples of northeastern North America have been deemed unacceptable after investigation.\nOakley (1979) suggested its development meant an almost complete re-writing of the evolution and cultural emergence of the human species.C, or radiocarbon, is a radioactive isotope of carbon with an atomic nucleus containing 6 protons and 8 neutrons.Its presence in organic materials is the basis of the radiocarbon dating method pioneered by Willard Libby and colleagues (1949) to date archaeological, geological and hydrogeological samples.\"Everything which has come down to us from heathendom is wrapped in a thick fog; it belongs to a space of time we cannot measure.We know that it is older than Christendom, but whether by a couple of years or a couple of centuries, or even by more than a millenium, we can do no more than guess.\" [Rasmus Nyerup, (Danish antiquarian), 1802 (in Trigger, 19)].", "domain": "chemistry", "round": 3} +{"url": "https://diversey.ie/en/solutions/food-and-beverage-production/knowledge-based-services/diversey-hygiene-academy/safe-handling-and-application-detergents-and-disinfectants", "date": "2023-10-02T15:23:02Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233511000.99/warc/CC-MAIN-20231002132844-20231002162844-00213.warc.gz", "language_score": 0.9099929332733154, "token_count": 265, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__121208178", "lang": "en", "text": "Safe Handling and Application of Detergents and Disinfectants\nLanguages Available: English\nCourse Modules: Safe Handling and Application of Detergents and Disinfectant\nDiversey wants to ensure that all cleaning chemicals are handled properly and safely to prevent accidents that could potentially hurt the user and affect the safety of others. The Safe Handling and Application of Detergents and Disinfectants course ensures a basic understanding of the potential risks of using cleaning chemicals and the processes that should be in place to minimise the risk.\nShould be mandatory for employees using cleaning chemicals in their day to day role\nSuitable for employees who may come into contact with hygiene chemicals\nThe training program will cover key areas to provide a better understanding of how to perform, in a safe manner, cleaning with chemicals. Key content includes:\nReasons for cleaning\nHow to clean\nFood safety regulations and requirements\nCleaning up after spillage of chemicals\nFirst aid treatment\nAccess and Purchase Options\nCompanies can purchase a package of modules to fit the needs of their workforce. Our sales representatives can help build training plans which are tailored to suit the needs of each company.", "domain": "chemistry", "round": 3} +{"url": "http://nano.tu-dresden.de/pages/paper_88.html", "date": "2018-06-22T03:12:48Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-26/segments/1529267864343.37/warc/CC-MAIN-20180622030142-20180622050142-00397.warc.gz", "language_score": 0.9498733878135681, "token_count": 265, "dump": "CC-MAIN-2018-26", "global_id": "webtext-fineweb__CC-MAIN-2018-26__0__34121277", "lang": "en", "text": "Development of novel scaffolds for tissue engineering by flock technology\nA. Walther, A. Bernhardt, W. Pompe, M. Gelinsky, B. Mrozik, G. Hoffmann, C. Cherif, H. Bertram, W. Richter, G. Schmack\nTextile Research Journal 77, 892-899 (2007)\nFlock technology is a method well known in the textile industry. Short fibers are applied almost vertically on a substrate, coated with a flocking adhesive. Until now, this technology has not been used in the field of biomaterials. Our aim was to use electrostatic flocking for fabricating a novel type of scaffolds for tissue engineering. This method offers the possibility to create matrices with anisotropic properties that have a high compressive strength despite high porosity. First, experiments were performed using a membrane made of mineralized collagen as substrate, gelatine as adhesive and polyamide flock fibers. Different kinds of cells were cultured in the scaffolds for up to six weeks. Using microscopic methods and biochemical analyses, we could demonstrate that cells adhered and proliferated well in this new type of scaffold. Therefore, we can summarize that flocking is a technology suitable for fabrication of scaffolds for cell cultivation and tissue engineering.", "domain": "chemistry", "round": 3} +{"url": "https://www.icis.com/resources/news/2016/08/22/10027484/russia-jan-july-chemical-production-index-up-1-year-on-year/", "date": "2017-07-21T17:00:33Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-30/segments/1500549423787.24/warc/CC-MAIN-20170721162430-20170721182430-00425.warc.gz", "language_score": 0.9555612802505493, "token_count": 567, "dump": "CC-MAIN-2017-30", "global_id": "webtext-fineweb__CC-MAIN-2017-30__0__134877533", "lang": "en", "text": "MOSCOW (MRC)--In July, Russian companies managed to achieve a positive growth of production of basic chemicals in Russia after a long negative period from April to June.\nIn general, the index of production of basic chemicals rose by 1% in the first seven months of 2016, according to official data.\nThe Federal Service of State Statistics (Rosstat) stated that last month's output of basic chemicals increased by 0.5% from July, whereas in April-June this figure was negative. However, despite several negative months, production of basic chemicals grew by 1% in January-July 2016.\nThus, 193,000 tonnes of ethylene was produced in July versus 224,000 tonnes a month earlier with the lower output caused by scheduled maintenance at Nizhnekamskneftekhim and a short outage at Angarsk Polymer Plant due to technical issues.\nIn general, over 1.6m tonnes of this olefin were produced in January-July 2016, down by 2.3% year on year.\nLast month’s production of benzene also decreased to 92,000 tonnes from 95,500 tonnes in June, also because of the shutdowns at the Nizhnekamsk and Angarsk’s plants. Overall output of these products reached 691,000 tonnes in the first seven months of 2016, down by 2.6% from the same period in 2015.\nJuly production of xylenes dropped to 46,100 tonnes from 48,300 tonnes a month earlier. 336,500 tonnes of xylenes were produced in Januay-July 2016, up by 4% year on year.\nJuly index of production of sodium hydroxide (caustic soda) rose to 93,300 tonnes (100% of the basic substance) versus 88,900 tonnes a month earlier.\nThe increased output of caustic soda was provided by SayanskKhimplast. Overall production of caustic soda totalled 642,000 tonnes in January-July 2016, down by 1.5% year on year. The main reason was a forced long shutdown at SayanskKhimplast.\nLast month’s output of mineral fertilizers was 1.639m tonnes (if recalculated for 100% of nutrients), up by 5% from June.\nRussian plants produced over 11.8m tonnes of fertilizer in the first seven months of the year, up by 0.1% year on year. Production of all types of fertilizers increased, with the exception of potash, the output of which decreased by 9.2%.\nMRC, a partner of ICIS, produces polymers news and pricing reports from Russia, Ukraine, Belarus, Uzbekistan and Kazakhstan.", "domain": "chemistry", "round": 3} +{"url": "https://wiki.oroboros.at/index.php/Huete-Ortega_2020_MitoFit_Preprint_Arch_EA", "date": "2023-12-02T16:00:41Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100427.59/warc/CC-MAIN-20231202140407-20231202170407-00827.warc.gz", "language_score": 0.7216647267341614, "token_count": 1177, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__113393988", "lang": "en", "text": "|Huete-Ortega M, Di Marcello M, Iglesias-Gonzalez J, Gnaiger E (2020) High-resolution respirometry for chloroplast and mitochondrial bioenergetics in Chlamydomonas reinhardtii ― towards biotechnology exploitations. https://doi.org/10.26124/mitofit:ea20.algaeurope.0001|\n» MitoFit Preprint Arch EA20.1.\nAbstract: Version 1 (v1) 2020-11-30 doi:10.26124/mitofit:ea20.algaeurope.0001\nChloroplast and mitochondrial bioenergetic control of algal growth and metabolite production is necessary to maintain metabolic integrity. In contrast to mammalian cells, algal mitochondria express alternative oxidases (AOX), which divert electron transfer from coenzyme Q (Q) away from cytochrome c oxidase (Complex IV, CIV) . In algae, therefore, we distinguish between respiration through the Q-AOX and Q-CIV branches of the electron transfer system. A better understanding of the contribution of both branches to mitochondrial dark respiration is required to optimize algal biomass and metabolite production for biotechnological purposes. High-resolution respirometry (HRR; Oroboros O2k) is widely used to assess mitochondrial respiration and other bioenergetic parameters in the biomedical field of mitochondrial and cell research . In our interdisciplinary study, we introduced a new method of studying oxygen kinetics [3,4] for the partitioning of dark respiration between the Q-AOX and Q-CIV branches in Chlamydomonas reinhardtii grown for biomass and lipid production . This method is based on the distinct oxygen affinities of these enzymes. In addition, the multimodal approach of the Oroboros O2k was extended using the novel PhotoBiology-Module of the NextGen-O2k for determining the maximum light-saturated and inorganic carbon-saturated photosynthesis rates [6,7]. This methodology allows for increasing our current knowledge of the bioenergetics of chloroplasts and mitochondria, which is of particular importance for biotechnological exploitations. This communication is part of the NextGen-O2k project that has received funding from the European Union’s Horizon 2020 research and innovation program under the grant agreement No 859770.\n• Keywords: photosynthesis, respiration, microalgae, high-resolution respirometry, O2 kinetics, NextGen • Bioblast editor: Huete-Ortega Maria\n- Young L, Shiba T, Harada S, Kita K, Albury MS, Moore AL (2013) The alternative oxidases: simple oxidoreductase proteins with complex functions. Biochem Soc Trans 41:1305-11.\n- Doerrier C, Garcia-Souza LF, Krumschnabel G, Wohlfarter Y, Mészáros AT, Gnaiger E (2018) High-Resolution FluoRespirometry and OXPHOS protocols for human cells, permeabilized fibers from small biopsies of muscle, and isolated mitochondria. Methods Mol Biol 1782:31-70.\n- Meszaros AT, Haider M, Di Marcello M, Gnaiger E (2018) High-resolution mitochondrial oxygen kinetics as diagnostic tool in Complex IV impairments. Abstract Mitochondrial Medicine 2018 Hinxton UK.\n- Di Marcello M, Iglesias-Gonzalez J, Meszaros AT, Haider M, Gnaiger E, Huete-Ortega M (2019) Partitioning between cytochrome c oxidase and alternative oxidase studied by oxygen kinetics of dark respiration in Chlamydomonas reinhardtii: a microalgae model organism. MitoFit Preprint Arch doi:10.26124/mitofit:ea19.MiPSchool.0005.v3\n- Pulz O, Gross W (2004) Valuable products from biotechnology of microalgae. App Microbiol Microbiol Biotech 65:635-48.\n- Giordano M, Pezzoni V, Hell R (2000) Strategies for the allocation of resources under sulfur limitation in the green alga Dunaliella salina. Plant Physiol 124:857-64.\n- Palmqvist K, Ögren E, Lernmark U (1994) The CO2-concentrating mechanism is absent in the green alga Coccomyxa: a comparative study of photosynthetic CO2 and light responses of Coccomyxa, Chlamydomonas reinhardtii and barley protoplasts. Plant Cell Envir 17:65-72.\n- Went N, Di Marcello M, Gnaiger E (2021) Oxygen dependence of photosynthesis and light-enhanced dark respiration studied by High-Resolution PhotoRespirometry. MitoFit Prep 2021.5. - »Bioblast link«\nPreprints for Gentle Science\nLabels: MiParea: Instruments;methods\nPreparation: Intact cells Enzyme: Complex IV;cytochrome c oxidase Regulation: Oxygen kinetics Coupling state: ROUTINE Pathway: Other combinations HRR: Oxygraph-2k, NextGen-O2k\nChlamydomonas, Preprints, Dark respiration, Photosynthesis, PB-Module, MitoFit 2021.5 PB", "domain": "chemistry", "round": 3} +{"url": "https://passyourranking.info/short-course-on-covering-the-basics/", "date": "2024-02-28T23:35:06Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707947474746.1/warc/CC-MAIN-20240228211701-20240229001701-00554.warc.gz", "language_score": 0.9573179483413696, "token_count": 1318, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__46470731", "lang": "en", "text": "Just How to Capture Carbon and also Transform it Into Electrical power As international warming worsens, even more companies are betting on means to capture carbon dioxide and turn it into electrical power. Click here for more info. How to Capture Carbon and Transform it Into Electricity As international warming worsens, more companies are betting on ways to record carbon dioxide as well as transform it into power. Governments are embracing ambitious targets for minimizing carbon discharges, as well as investors are ending up being a lot more worried about the dangers of climate adjustment. However, while carbon-capture modern technologies have actually been around for decades, they are still incredibly expensive and power intensive. By examining the chemical bonds between co2 and numerous particles, researchers are creating better products as well as techniques to record carbon. Among these new methods is based on electrochemistry. This approach predicts the stamina of a carbon dioxide bond. The scientists can then use this details to recognize ideal molecular prospects. For example, they can use this technique to make a molecule that will trap CO2. This new method might result in less costly, much more reliable carbon capture technologies. Scientists have actually been establishing methods to turn heat-trapping gases right into useful materials, such as electricity as well as hydrogen. These methods may be needed widespread to maintain global warming listed below 2.7 degrees Fahrenheit as well as repel the consequences of climate modification. The most prominent method of carbon capture is photosynthesis. Plants make use of sunlight light to fix carbon dioxide into biomass, and also many scientists are studying methods to resemble the procedure. A comparable procedure happens in aquatic environments, where shellfish usage liquified carbonate to form strong frameworks. These frameworks are after that deposited safely in rocks throughout the globe. Read more here on this page to discover more about this product. Carbon capture is a needed enhance to various other procedures for addressing climate modification. It is an important public service that must not be dependent on earnings. As carbon capture technologies become less expensive, much more countries will certainly have the ability to embrace this technology as well as record more carbon. Eventually, carbon capture will end up being less expensive and a lot more widespread, making it possible for even richer countries to capture even more CO2. The technology can likewise record carbon dioxide from various other resources, consisting of industrial plants such as a cement manufacturing facility or an ammonia plant. Presently, the primary emphasis of carbon capture efforts is in coal-fired power plants. However this could change with the application of new government laws. While there is a small market for carbon sequestration in items, it’s unlikely to get to the scale necessary to attain its full potential till federal government plan incentivizes it. Business are increasingly looking at the benefits of using carbon dioxide in oilfields. Occidental, for instance, is a leader in enhanced oil healing and utilizes mostly all of the carbon dioxide it removes from oil tanks. By utilizing this modern technology to catch carbon, Occidental can likewise take advantage of tax motivations and also satisfy corporate ecological targets. However, it will also need to attend to regulatory concerns associated with discharges. In the future, Occidental is planning to utilize more of its captured carbon in their oil wells. This innovation can be made use of at existing as well as new coal-fired nuclear power plant. However, it is costly. The process calls for big tools that can lower the performance of the wind turbine. Governments are taking on enthusiastic targets for decreasing carbon emissions, as well as capitalists are ending up being much more concerned regarding the dangers of environment modification. Nevertheless, while carbon-capture innovations have been around for years, they are still exceptionally pricey as well as power extensive. By examining the chemical bonds between co2 and also various molecules, scientists are developing better products and also methods to capture carbon. One of these new methods is based on electrochemistry. This technique forecasts the toughness of a co2 bond. The researchers can then use this info to identify ideal molecular prospects. As an example, they can utilize this approach to make a particle that will certainly catch carbon dioxide. This brand-new technique might lead to cheaper, more efficient carbon capture technologies. Researchers have actually been developing approaches to transform heat-trapping gases right into valuable compounds, such as electrical energy and hydrogen. These techniques might be required on a large scale to maintain global warming below 2.7 degrees Fahrenheit as well as ward off the consequences of environment modification. The most famous method of carbon capture is photosynthesis. Plants utilize sunlight light to deal with carbon dioxide into biomass, and also numerous scientists are examining ways to imitate the procedure. A similar process happens in aquatic environments, where shellfish usage liquified carbonate to create strong structures. These structures are then deposited securely in rocks throughout the world. Carbon capture is a required enhance to various other procedures for dealing with environment adjustment. It is an essential civil service that must not hinge on profit. As carbon capture modern technologies come to be less expensive, a lot more nations will certainly be able to adopt this technology as well as record more carbon. Ultimately, carbon capture will end up being cheaper as well as more extensive, making it possible for even richer countries to record even more CO2. Read more here on this page to discover more about this product. The technology can likewise record co2 from various other resources, including plants such as a concrete manufacturing facility or an ammonia plant. Currently, the primary focus of carbon capture efforts is in coal-fired power plants. Click for more info on this website. Yet this might alter with the application of brand-new federal government policies. While there is a tiny market for carbon sequestration in items, it’s unlikely to reach the scale required to achieve its complete possibility till government policy incentivizes it. Business are significantly taking a look at the benefits of making use of carbon dioxide in oilfields. Occidental, for instance, is a leader in enhanced oil recovery and also utilizes almost all of the co2 it draws out from oil tanks. By using this technology to catch carbon, Occidental can also gain from tax obligation motivations as well as satisfy company environmental targets. Nevertheless, it will certainly also need to attend to governing issues related to emissions. In the future, Occidental is intending to use more of its caught carbon in their oil wells. This innovation can be made use of at existing as well as brand-new coal-fired power plants. Nonetheless, it is costly. The procedure needs big devices that can minimize the effectiveness of the turbine.\nCitation: More Bonuses", "domain": "chemistry", "round": 3} +{"url": "https://www.alzforum.org/news/research-news/dynamic-glycosylation-neurons-may-be-linked-memory-pathology", "date": "2021-04-18T03:51:09Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-17/segments/1618038464146.56/warc/CC-MAIN-20210418013444-20210418043444-00516.warc.gz", "language_score": 0.8836542963981628, "token_count": 639, "dump": "CC-MAIN-2021-17", "global_id": "webtext-fineweb__CC-MAIN-2021-17__0__167672158", "lang": "en", "text": "A new technique for detecting proteins modified by β-N-acetyl-D-glucosamine (i.e., O-GlcNAc glycosylation) reveals that the process is reversible and dynamic in neurons and may even play a role in memory. Linda Hsieh-Wilson, California Institute of Technology, Pasadena, and colleagues have developed a quantitative isotopic and chemoenzymatic tagging system (QUIC-Tag) to detect glycosylated proteins inside neurons. Unlike some other methodologies, QUIC-Tag does not require metabolic incorporation of isotopes or rounds of cell division. Cellular levels of O-GlcNAc-proteins are also unperturbed. The technique, which involves protection of the O-GlcNAc moieties by biotinylation followed by avidin-based purification and then mass spectrometry detection, is particularly suited to non-dividing cells, such as neurons.\nThe technique is explained in detail in the May 13 Nature Chemical Biology online. First author Nelly Khidekel and colleagues also describe how they used the QUIC-Tag method to detect kainic acid-stimulated glycosylation in rat brain. The glutamate receptor agonist reproducibly elevated thirteen of 83 O-GlcNAc-derived peptides detected in the cerebral cortices. One of the peptides derives from the transcription factor early growth response-1 (EGR-1), which has been linked to long-term memory formation (see Jones et al., 2001).\nKhidekel and colleagues also found that glycosylation is reversible, suggesting that it may serve a regulatory function akin to phosphorylation and other post-translational modifications. On that note, they report that the axonal guidance protein CRMP-2 is glycosylated near sites that spur incorporation of the protein into neurofibrillary tangles when phosphorylated. Tau, and amyloid-β precursor protein, are also known to be modified by glycosylation. “Deciphering the mechanisms that regulate the interplay of glycosylation and phosphorylation for these and other proteins may have important ramifications for the study of neuronal signaling and neurodegenerative disorders,” write the authors.—Tom Fagan\n- Jones MW, Errington ML, French PJ, Fine A, Bliss TV, Garel S, Charnay P, Bozon B, Laroche S, Davis S. A requirement for the immediate early gene Zif268 in the expression of late LTP and long-term memories. Nat Neurosci. 2001 Mar;4(3):289-96. PubMed.\nNo Available Further Reading\n- Khidekel N, Ficarro SB, Clark PM, Bryan MC, Swaney DL, Rexach JE, Sun YE, Coon JJ, Peters EC, Hsieh-Wilson LC. Probing the dynamics of O-GlcNAc glycosylation in the brain using quantitative proteomics. Nat Chem Biol. 2007 June 1;3(6):339-48.", "domain": "chemistry", "round": 3} +{"url": "https://www.chemistryviews.org/details/news/2081271/Improving_Memory/", "date": "2023-12-08T19:57:38Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100769.54/warc/CC-MAIN-20231208180539-20231208210539-00631.warc.gz", "language_score": 0.8177805542945862, "token_count": 346, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__116572634", "lang": "en", "text": "Long-term memory, namely the capacity of storing information for a long period of time, depends on protein synthesis. This event is triggered by eIF2α (eukaryotic translation initiation factor 2α). When present in its unphosphorylated state, this protein initiates the translation of RNA into proteins. Conversely, eIF2α becomes inactive when phosphorylated. In this condition, protein synthesis is blocked and the long-term memory impaired.\nCarmela Sidrauski, University of California, USA, and colleagues discovered ISRIB (pictured), a molecule which renders the cells insensitive to eIF2α phosphorylation. The new compound, a symmetric bis-glycolamide with a central bi-substituted cyclohexane, increased protein synthesis and improved long term memory when administered to rodents. Moreover, it showed good pharmacokinetic properties and it did not elicit toxic effects.\nISRIB might, therefore, constitute a useful treatment for diseases associated to memory impairment.\n- Pharmacological brake-release of mRNA translation enhances cognitive memory\nC. Sidrauski, D. Acosta-Alvear, A. Khoutorsky, P. Vedantham, B. R. Hearn, H. Li, K. Gamache, C. M. Gallagher, K. K.-H. Ang, C. Wilson, V. Okreglak, A. Ashkenazi, B. Hann, K. Nader, M. R. Arkin, A. R. Renslo, N. Sonenberg, P. Walter\neLife 2013, 2, e00498–e00498.", "domain": "chemistry", "round": 3} +{"url": "https://insights.ovid.com/toxicology-applied-pharmacology/taap/2014/08/150/attenuation-25-35-induced-parallel-autophagic/7/00007821", "date": "2020-09-28T11:59:31Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-40/segments/1600401600771.78/warc/CC-MAIN-20200928104328-20200928134328-00118.warc.gz", "language_score": 0.896914005279541, "token_count": 483, "dump": "CC-MAIN-2020-40", "global_id": "webtext-fineweb__CC-MAIN-2020-40__0__98126115", "lang": "en", "text": "|| Checking for direct PDF access through Ovid\nAmyloid-beta (Aβ) has a pivotal function in the pathogenesis of Alzheimer's disease. To investigate Aβ neurotoxicity, we used an in vitro model that involves Aβ25–35-induced cell death in the nerve growth factor-induced differentiation of PC12 cells. Aβ25–35 (20 μM) treatment for 24 h caused apoptotic cell death, as evidenced by significant cell viability reduction, LDH release, phosphatidylserine externalization, mitochondrial membrane potential disruption, cytochrome c release, caspase-3 activation, PARP cleavage, and DNA fragmentation in PC12 cells. Aβ25–35 treatment led to autophagic cell death, as evidenced by augmented GFP-LC3 puncta, conversion of LC3-I to LC3-II, and increased LC3-II/LC3-I ratio. Aβ25–35 treatment induced oxidative stress, as evidenced by intracellular ROS accumulation and increased production of mitochondrial superoxide, malondialdehyde, protein carbonyl, and 8-OHdG. Phytoestrogens have been proved to be protective against Aβ-induced neurotoxicity and regarded as relatively safe targets for AD drug development. Gypenoside XVII (GP-17) is a novel phytoestrogen isolated from Gynostemma pentaphyllum or Panax notoginseng. Pretreatment with GP-17 (10 μM) for 12 h increased estrogen response element reporter activity, activated PI3K/Akt pathways, inhibited GSK-3β, induced Nrf2 nuclear translocation, augmented antioxidant responsive element enhancer activity, upregulated heme oxygenase 1 (HO-1) expression and activity, and provided protective effects against Aβ25–35-induced neurotoxicity, including oxidative stress, apoptosis, and autophagic cell death. In conclusion, GP-17 conferred protection against Aβ25–35-induced neurotoxicity through estrogen receptor-dependent activation of PI3K/Akt pathways, inactivation of GSK-3β and activation of Nrf2/ARE/HO-1 pathways. This finding might provide novel insights into understanding the mechanism for neuroprotective effects of phytoestrogens or gypenosides.", "domain": "chemistry", "round": 3} +{"url": "https://www.co.pierce.wa.us/5913/High-Friction-Surface-Treatment", "date": "2019-07-19T20:51:16Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-30/segments/1563195526359.16/warc/CC-MAIN-20190719202605-20190719224605-00495.warc.gz", "language_score": 0.939095139503479, "token_count": 263, "dump": "CC-MAIN-2019-30", "global_id": "webtext-fineweb__CC-MAIN-2019-30__0__12923372", "lang": "en", "text": "Public Works has received a $763,000 federal Safety Program grant to install a new roadway coating at six locations throughout unincorporated Pierce County. The coating has been shown nationally to be highly effective at increasing safety and reducing collisions on roadway curves with high driving-off-road types of crashes. It does this by increasing the skid resistance of the roadway surface and helping motorists maintain better control negotiating the curve in both dry and wet conditions. A Centerline Rumble Strip will also be installed at three locations where noted.\nThe federal grant funding will allow the installation of this thin layer of specially engineered, durable, high friction coating at the following locations:\nOrville Road East - curve west of 168th Avenue Court East\nThe technical name for this specialized coating is “High Friction Surface Treatment” or HFST. It’s a two-part coating made up of a high strength polymeric resin binder (the “glue”) and a high durability Calcined Bauxite aggregate (the “rock”). These two parts are joined on the existing roadway to produce a surface of high skid and wear resistance.\nMore information of this highly effective and innovative roadway surface treatment can be found on the Federal Highway Administrations “Safety” website:", "domain": "chemistry", "round": 3} +{"url": "https://trade-mart.co.uk/products/bond-it-drive-alive-clear-coat-block-sealer-for-paths-and-driveways", "date": "2021-05-11T09:36:43Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-21/segments/1620243991982.8/warc/CC-MAIN-20210511092245-20210511122245-00080.warc.gz", "language_score": 0.8327348232269287, "token_count": 250, "dump": "CC-MAIN-2021-21", "global_id": "webtext-fineweb__CC-MAIN-2021-21__0__637926", "lang": "en", "text": "Bond-It Drive Alive Clear Coat Block Sealer For Paths and Driveways\nBond-It BDCCBS4 Drive Alive Clear Coat Block Sealer For Paths and Driveways 4L.. A ready-to-use, clear sealant for block paving, paths and drive ways. ..Protects from water penetration, staining and dirt/grime build-up. ..Advanced Hybrid technology Ready-to-use Excellent abrasion and chemical resistance Inhibits organic growth Solvent-free. ..BENEFITS: - ..Solvent-free formulation - ..low odour. - ..Facilitates easier cleaning. - ..Improves water resistance and UV resistance. - ..Contains fungicide which retards mould growth. ..APPLICATION: Ready-to-use, and does not require diluting. ..Stir thoroughly before using and ensure the surface is completely dry prior to application. ..Apply using a brush, roller or squeegee, ensuring that no pooling or ponding occurs. ..Two coats are recommended, allow a minimum of 4 hours between coats. ..Cold or humid conditions will slow drying times. ..Only to be used in conjunction with other Bond It Drive Alive products.", "domain": "chemistry", "round": 3} +{"url": "http://pregi.bi.up.ac.za/pre_gi_swbit.php?blast=blastn&query=NC_008344:2374761&subject=NC_007712:2978000", "date": "2021-04-21T01:17:00Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-17/segments/1618039503725.80/warc/CC-MAIN-20210421004512-20210421034512-00524.warc.gz", "language_score": 0.8469984531402588, "token_count": 315, "dump": "CC-MAIN-2021-17", "global_id": "webtext-fineweb__CC-MAIN-2021-17__0__69705006", "lang": "en", "text": "Query: NC_008344:2374761 Nitrosomonas eutropha C91, complete genome Lineage: Nitrosomonas eutropha; Nitrosomonas; Nitrosomonadaceae; Nitrosomonadales; Proteobacteria; Bacteria General Information: Nitrosomonas eutropha C91 was isolated from a sewage disposal plant in Chicago. Ammonia-oxidizing bacterium. This species consists of ammonia-oxidizing bacteria that catalyze the oxidation of ammonia to nitrite and contribute to the global cycling of nitrogen (a process called nitrification). This obligate chemolithoautotroph is studied for that reason.\n- Sequence; - BLASTN hit (Low score = Light, High score = Dark) - hypothetical protein; - cds: hover for description\nLineage: Sodalis glossinidius; Sodalis; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria\nGeneral Information: Sodalis glossinidius is known exclusively in endosymbiosis with tsetse flies. It is maternally transmitted, and is one of the few bacterial endosymbionts of insects that can be cultured successfully in vitro. Genome data reveals a high proportion of pseudogenes in this species, many of which were, in their functional state, involved in defense or transport of carbohydrates and inorganic ions. This suggests a degenerative adaptation to the immunity and restricted nutritional status of the host.", "domain": "chemistry", "round": 3} +{"url": "https://www.duo.uio.no/handle/10852/40677", "date": "2020-10-26T00:06:17Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-45/segments/1603107890028.58/warc/CC-MAIN-20201025212948-20201026002948-00654.warc.gz", "language_score": 0.9514179825782776, "token_count": 384, "dump": "CC-MAIN-2020-45", "global_id": "webtext-fineweb__CC-MAIN-2020-45__0__877333", "lang": "en", "text": "Protein methylation is a post-translational modification best studied in regards to histones and the histone code. In recent years, more studies have begun to unearth non-histone protein methylation, in most cases however, the responsible enzymes remain unidentified. Methylation of non-histone proteins could impart new characteristics, such as altering protein-protein interactions, stability, localization, and/or enzymatic activities. Recently, a novel family of ten lysine specific methyltransferases (KMTs) was identified, of which only a few have thus far been characterized. These include valosine-containing protein KMT (VCP-KMT) (Kernstock et al., 2012), calmodulin-KMT (Magnani et al., 2010) and heat shock protein 70-KMT (Hsp70-KMT)(Jakobsson et al., 2013). Characterization of the remaining members of this family, including methyltransferase like 20 (METTL20), would expand the knowledge of non-histone methyltransferases. In this study, data are presented that reveal the identity of two proteins in Agrobacterium tumefaciens (A. tumefaciens) that are substrates of the bacterial orthologue of METTL20. The sites of methylation for each substrate were ascertained by mutagenesis and fluorography. To elucidate the biological role of the bacterial orthologue of METTL20, a strain of A. tumefaciens was generated with a knockout (KO) of the METTL20 gene. Wild type (WT) and KO bacteria were subject to various growth conditions and stresses in an attempt to uncover a condition in which one strain outperformed the other in regards to viability and/or growth. A potential phenotype was discovered that could involve the viability and ability to grow under certain stress conditions.", "domain": "chemistry", "round": 3} +{"url": "https://www.airpro.ie/applications/oxygen/", "date": "2023-12-07T06:46:16Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100650.21/warc/CC-MAIN-20231207054219-20231207084219-00366.warc.gz", "language_score": 0.9249317646026611, "token_count": 260, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__33645974", "lang": "en", "text": "AirPro provides on site, on demand oxygen supply solutions, customised for your challenge.\nAirPro’s Oxygen Generators eliminate the expense, inconvenience, hazardous handling, and storage problems associated with purchased liquid or the transportation of high pressure oxygen cylinders.\nWith PSA and VSA technology these generators are the most efficient and dependable systems available today. Fully automatic, they require no supervision for operation.Traditional supply methods include high pressure cylinders, liquid mini tanks and bulk storage vessels. These present many on-going costs such as rental, refill, delivery, environmental levy and order processing charges. AirPro offers an ideal solution to this requirement with a comprehensive range of cost effective oxygen gas generation systems which enable users to produce their total demand for oxygen gas on their premises, under their complete control.\nAs a result, companies can generate as much or as little oxygen as needed, at a fraction of the cost of having the gas delivered by an external supplier. Once an oxygen generation system has been purchased, such costs can be reduced by up to 90%. Customers benefit from immediate cash flow savings and long-term price stability.\nOur Oxygen Generators will give your business:\n- Lower cost and long term price stability\n- Increased productivity and profitability\n- Safer working environment", "domain": "chemistry", "round": 3} +{"url": "https://thomsongroup.com.au/product/enotec-comtec-6000-in-situ-oxygen-coe-analyser/", "date": "2024-03-01T05:29:22Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707947474948.91/warc/CC-MAIN-20240301030138-20240301060138-00630.warc.gz", "language_score": 0.8948240876197815, "token_count": 279, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__20056838", "lang": "en", "text": "The COMTEC 6000 is an In Situ analyzer for measurement of oxygen and COe (sum of unburned molecules such as carbon monoxide, methane or hydrogen) in flue and process gases. This enables the redundant measurement of both gases with high accuracy in real time. This is achieved by combining the ENSITU MXP sensor for COe analysis with the technology of ENSITU MLT sensor which measures oxygen content.The COMTEC 6000 ensures combustion optimisation through accurate and reliable gas analysis. Both sensors are located within the process, as the probe is installed directly in the flue gas duct. This allows for fast and continuous flue gas data collection, creating a fast response rate to changes in the flue gas composition. The analyzer was designed was to be maintenance free, with minimal calibration requirements and complete user-friendliness. Furthermore high costs for investment and maintenance, especially when comparing to extractive analyzers, can be avoided.\n– InSitu measurements in real-time.\n– Accuracy deviation of the ENSITU MLT sensor of only 0,2 % of the measured value.\n– Maintenance-free thanks to the robust construction and superior technology.\n– Gas-tight sensor design for a safe and durable operation.\n– System History memory and sensor life display.\n– Self monitoring of the device functions.", "domain": "chemistry", "round": 3} +{"url": "http://samsungcurvedtv.buzzebees.com/zahoxul96031.html", "date": "2021-10-25T16:11:12Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-43/segments/1634323587719.64/warc/CC-MAIN-20211025154225-20211025184225-00130.warc.gz", "language_score": 0.9523751139640808, "token_count": 606, "dump": "CC-MAIN-2021-43", "global_id": "webtext-fineweb__CC-MAIN-2021-43__0__20505578", "lang": "en", "text": "The most widely known form of radiometric dating is carbon-14 dating. But carbon-14 dating wont work on dinosaur bones. The half-life of carbon-14 is only 5,730 years, so carbon-14 dating is only effective on samples that are less than 50,000 years old.\nHow can carbon-14 determine the age of a fossil?\nBecause carbon-14 decays at this constant rate, an estimate of the date at which an organism died can be made by measuring the amount of its residual radiocarbon.\nCan you use carbon-14 to figure out the age of a Mesozoic dinosaur fossil Why or why not?\nNote: radiocarbon (carbon 14) dating cannot be used for Mesozoic fossils!\nWhy is carbon dating ineffective in finding the ages of dinosaur bones?\nTo determine the age of a dinosaur fossil, carbon dating can never be used. By the time a dinosaur fossil was found, any carbon-14 the organism would have taken up and incorporated into its tissues during its life, would have decayed too much to be useful as a tool to determine its age.\nWhy carbon 14 dating cant be used to determine age of fossils when it is 70 years old?\nBecause of the short length of the carbon-14 half-life, carbon dating is only accurate for items that are thousands to tens of thousands of years old. Most rocks of interest are much older than this. Geologists must therefore use elements with longer half-lives.\nThe dinosaurs that comingled with our ancient ancestors were modern birds—the closest natural relatives to the extinct dinosaurs—which means that we live with dinosaurs too. Millions of years later, humans do live together in domestic bliss with dinosaurs.\nWhat was the first animal on Earth?\ncomb jelly A comb jelly. The evolutionary history of the comb jelly has revealed surprising clues about Earths first animal.\nWhat was a dinosaurs lifespan?\nEarly estimates of 300-year lifespans for the largest sauropods were based on comparisons with crocodiles and turtles, which have much slower metabolisms. The consensus is now that Apatosaurus and Diplodocus dinosaurs probably only lived for 70 or 80 years, which is about the same as an elephant today.\nIs carbon-14 harmful to humans?\nCarbon-14 is a low energy beta emitter and even large amounts of this isotope pose little external dose hazard to persons exposed. The beta radiation barely penetrates the outer protective dead layer of the skin of the body. 14 C compounds should be handled with gloved hands, and in some cases, with double gloves.\nHow old is oldest fossil?\n3.5 billion years old Today, little evidence remains of Earths earliest organisms. Microscopic fossils estimated to be 3.5 billion years old are credited with being the oldest fossils of life on Earth, though some experts have questioned whether chemical clues in the so-called fossils were truly biological in origin.", "domain": "chemistry", "round": 3} +{"url": "http://www.molecularcircuit.com/2016/10/24/nad-fat-burning-capacity-is-a-critical-factor-that-regulates-the/", "date": "2023-09-25T00:49:26Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233506669.96/warc/CC-MAIN-20230924223409-20230925013409-00469.warc.gz", "language_score": 0.9335448741912842, "token_count": 1052, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__148444176", "lang": "en", "text": "NAD fat burning capacity is a critical factor that regulates the metabolism energy production and DNA repair of cells . . During skeletal muscle contraction AMP/ATP and NAD/NADH ratios increase. This has been shown to increase the activity of AMP activated protein kinase (AMPK) and the activities of many other NAD metabolism related protein kinases including nicotinamide phosphoribosyltransferase (NAMPT) . NAMPT also known as visfatin is an enzyme that converts nitotinamide into nicotinamide mononucleotides and is the rate limiting enzyme in this reaction . It is well known that synthesized NAD can be an important factor for most intercellular processes. Elevated NAD levels impact energy fat burning capacity for muscle tissue contraction and mitochondrial biogenesis and raised NAD levels can also increase SIRT 1 expression . As a result upregulated SIRT1 increases the deacetylation of signal proteins such as PGC-1α which is associated with the upregulation of genes involved in mitochondrial fatty acid oxidation [10 11 In addition NAD acts as an electron acceptor in energy producing processes such as the TCA cycle and electron transport system . In skeletal muscle NAMPT is usually increased by exercise or calorie restriction and is dependent on AMPK activation . Treatment with the AMPK activator AICAR (5-Aminoimidazole-4-carboxamide ribonucleotide) and exercise both increased NAMPT expression and activity in skeletal muscle . AMPK γ knock down mice showed a decrease in exercise induced NAMPT expression indicating that AMPK is likely a tightly regulated NAMPT transcription factor . AMPK activity is PVR usually regulated by allosteric AMP binding while AMPK phosphorylation is usually regulated by calmodulin kinase kinase (CaMKK) . In addition 15291-75-5 supplier Camkkβ also phosphorylates Ser-27 and Ser-47 on SIRT1 in brain tissue which increases SIRT1’s anti-inflammatory capacity . Moreover mitochondrial biogenesis and energy production can be regulated by CAMKII where phosphorylation can be regulated by various factors . These results indicate that AMPK phosphorylation and calcium signal related protein activation regulate mitochondrial biogenesis via deacetylation regulating proteins including SIRT1 [20 21 However a 15291-75-5 supplier few studies have reported that NAMPT activation or expression is usually induced by not only exercise or muscle contraction but also by a calcium related SIRT1 regulating mechanism. In this study we examined the effect of NAMPT inhibition using FK-866 (NAMPT specific inhibitor) on 15291-75-5 supplier ES-induced muscle contraction mediated SIRT1-PGC-1α signals and on mitochondrial biogenesis. Because NAD has a robust effect on SIRT1 related PGC-1α deacetylation we hypothesized that 15291-75-5 supplier this NAMPT signal pathway would be an important upregulator in genes involved in mitochondrial biogenesis gene regulation and muscle contraction. Moreover the calmodulin was examined by us activated protein kinase inhibitor on these signals. Overall the goal of this research was to research the result that NAD fat burning capacity via NAMPT legislation and SIRT1 activation possess on mitochondrial biogenesis during skeletal muscles cell contraction. Strategies Experimental animal 8 C57BL/6 mice were useful for this scholarly research. All mice were housed in plastic material cages and received regular food and water. The temperatures and dampness in the area were preserved at 23~25℃ and 60~70% respectively. Furthermore the light was managed in 12 hour cycles. All mice weighed 25 ± 1 approximately.32g. Administration and experimental techniques for the pets found in this research were in conformity with ethics rules of the pet Examining Ethics Committee of Chonbuk School (2014-1-0039). Parting of skeletal muscles primary muscles cell To be able to obtain a one muscle fibers for experimental reasons each C57BL/6 mice had been sacrificed by cervical dislocation as well as the gastrocnemius gathered. The skeletal muscles was then placed into a higher blood sugar Eagle’s minimal important moderate (DMEM) buffer formulated with 15291-75-5 supplier 0.2% type Ⅰ collagenase and incubated at 80~90 RPM for just two hours within a 37℃ shaking water shower. When enzymatic parting was completed a separated muscles fiber was gathered with a pasteur pipette and transferred to a petri dish. The muscles fiber was after that transferred to a fresh culture dish formulated with a DMEM-FBS buffer that made up of 10% equine serum and 10% fatal bovine serum (FBS) and stored in a CO2 incubator until the experiment. Assessment of mitochondrial mRNA regulation using real-time PCR methodology. Mitochondrial mRNA was quantitatively analyzed in skeletal muscle mass cells using ABI 7300 real-time PCR.", "domain": "chemistry", "round": 3} +{"url": "https://www.acq.osd.mil/eie/eer/ecc/pfas/pfas101/drinking-ground-water.html", "date": "2024-03-02T16:05:35Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707947475833.51/warc/CC-MAIN-20240302152131-20240302182131-00145.warc.gz", "language_score": 0.9514583945274353, "token_count": 1282, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__164885423", "lang": "en", "text": "As testing data of PFAS is collected, the context of what these PFAS sampling results represent and an overview of how levels of PFAS found in groundwater differ from PFAS found in drinking water are needed to better understand the data and what it means for human exposure.\nDrinking water is regulated by the Safe Drinking Water Act to ensure that chemicals found in potable water are below levels that could pose a health risk to humans. Water used for drinking water is typically treated prior to being distributed to the public for consumption. It is the treated water that reaches the public through a tap as drinking water; it is tested frequently to ensure that water quality meets federal and state regulations. Details on DoD’s testing and actions for on-base drinking water can be found here.\nWhen DoD talks about cleaning up pollutants released into the environment under the federal Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA), it includes pollutants that are found in groundwater and surface water. Through the CERCLA process, DoD uses and includes all applicable and relevant regulations that protect human health and the environment for site conditions.\nGroundwater:Groundwater can be a source for drinking water, but it is not typically potable water; that is, consumers are not drinking the groundwater directly without prior treatment by a public water system. For that reason, PFAS levels in groundwater are addressed under CERCLA with different requirements for cleanup. Each location where PFAS is found may have site specific conditions that will affect the time needed to complete each phase of the CERCLA process. Unless there is an immediate exposure threat to human health (that can be addressed at any point in the CERCLA process with an interim removal action), it often takes years to investigate if there was a release, determine the extent of the release, identify site conditions, and develop a cleanup strategy appropriate for that specific location. More information on DoD’s cleanup efforts can be found on our PFAS Data webpage.\nOff-Base Drinking Water:Finally, there are cases where groundwater is being used as drinking water, most often found in private residential wells. DoD refers to these locations and this water as “off-base drinking water.” While EPA does not regulate private wells nor does it provide recommended criteria or standards for individual wells, DoD has identified locations where PFAS releases off-base have impacted drinking water and taken immediate action to provide residents alternate water. More information on these response actions can be found here.\nIn addition to the response actions that have been taken, DoD conducts sampling of drinking water off-base to ensure it identifies potential impacts of PFAS resulting from DoD activities. Final testing results for PFAS in off-base drinking water in an area in the United States located adjacent to and down gradient from a DoD military installation, FUDS, or National Guard facility are searchable by state here.\nGroundwater exists in underground aquifers and flows and migrates into the bedrock through the soil. Groundwater can exist at varying quantities and varying depths, from shallow levels of 1 foot below the surface to hundreds of feet deep. Depending on a number of factors, including the conditions of the soil, the amount of rainfall, nearby surface waters, drinking water wells, land use, etc. groundwater can migrate slowly or quickly (extending further distances).\nGroundwater can be a source for drinking water, but unlike “drinking water,” it is not consumed directly. For that reason, people are not typically exposed to any pollutants that exist in the groundwater and the levels of pollutants are regulated differently than that in drinking water.\nYes. DoD has established policies for regular, periodic sampling of on-base drinking water to ensure safe drinking water for military, civilians, and their families. More information can be found here.\nNo. Groundwater is not consumed as drinking water at any military installation. It is tested at varying underground depths and not at the tap or faucet. Before drinking water reaches the tap, it undergoes treatment to ensure that the water quality meets EPA's standards for drinking water. DoD has tested all drinking water on military installations to ensure that it meets all federal and state water quality requirements. DoD has taken action at any location where on-base drinking water exceeded 70 parts per trillion (ppt) of PFOS and PFOA.\nDoD also identified any groundwater used as a source of drinking water in private water wells. DoD has taken immediate action to provide alternative drinking water to those residents where PFAS levels exceeded 70ppt. Response actions from DoD have included providing bottle water, installing filtration systems for houses, and connecting houses to municipal water systems. The EPA does not regulate private wells nor does it provide recommended criteria or standards for individual wells.\nDoD has investigated locations and concentrations where PFAS has migrated or been released off-base to determine necessary cleanup actions. DoD identified any groundwater used as a source of drinking water for private water wells and has taken immediate action to provide alternative drinking water to those residents where levels of PFOS and PFOA exceeded 70 parts per trillion (ppt). Response actions DoD has taken include providing bottled water, installing filtration systems for houses, and connecting houses to municipal water systems. The EPA does not regulate private wells nor does it provide recommended criteria or standards for individual wells.\nDoD’s cleanup program is risk-based, resulting in a “worst first” approach. Testing results of PFAS in groundwater at a location may indicate high levels of PFAS, however it is only one factor when determining a site’s risk to human health and the environment. Other factors that could determine a site’s risk and proposed cleanup plan and schedule include the complexity of the site’s groundwater and geological conditions, the proximity to a drinking water source, the potential human exposure routes, and how quickly it is migrating.\nDoD takes into account these considerations, evaluating relative risk and sequencing for cleanup using DoD’s Relative Risk Site Evaluation (RRSE) framework. The Department developed the RRSE framework in consultation with regulators and community stakeholders to provide a consistent approach to prioritize known or suspected releases of hazardous substances and pollutants or contaminants for cleanup.", "domain": "chemistry", "round": 3} +{"url": "https://ideanitro.com/how-to-keep-chlorine-floater-out-of-skimmer/", "date": "2024-04-13T00:46:30Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712296816465.91/warc/CC-MAIN-20240412225756-20240413015756-00605.warc.gz", "language_score": 0.8720690011978149, "token_count": 580, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__112944281", "lang": "en", "text": "Keeping a chlorine floater out of the skimmer is important because chlorine tablets or floaters placed directly in the skimmer can damage the skimmer and pool equipment due to their concentrated chemical content. To prevent this, follow these steps to keep the chlorine floater out of the skimmer:\n- Use a Floating Chlorine Dispenser:\n- Invest in a floating chlorine dispenser or floater specifically designed for holding chlorine tablets. These devices are designed to stay afloat in the pool water, allowing the chlorine to dissolve slowly without coming into direct contact with the skimmer.\n- Adjust the Floater’s Settings:\n- Most floating chlorine dispensers have adjustable settings to control the chlorine release rate. Follow the manufacturer’s instructions to set the dispenser to the appropriate level for your pool size and chlorine needs.\n- Place the Floater Away from the Skimmer:\n- Position the floating chlorine dispenser away from the skimmer and pool equipment. Place it in the middle of the pool or at least a few feet away from the skimmer to ensure it doesn’t get drawn into the skimmer.\n- Use Skimmer Weirs or Baskets:\n- Skimmer weirs or baskets are designed to trap debris and prevent large objects from entering the skimmer. Make sure your skimmer has a weir or basket in place to help keep the floater out.\n- Check Water Flow:\n- Ensure that the water flow in your pool is properly balanced. If the skimmer is pulling water too strongly, it may pull the floater towards it. Adjust the water flow if necessary.\n- Install a Chlorine Tablet Dispenser in the Skimmer:\n- If you prefer to use a skimmer-based chlorine tablet dispenser, ensure it’s a dedicated, built-in unit designed for this purpose. These units are designed to safely hold and dissolve chlorine tablets within the skimmer.\n- Consider In-Line Chlorinators:\n- An in-line chlorinator can be installed in the pool’s plumbing system, allowing you to introduce chlorine tablets directly into the water circulation system. This keeps the chlorine away from the skimmer entirely.\n- Monitor and Adjust:\n- Regularly check the position of the floater and make any necessary adjustments to keep it away from the skimmer. This may be needed due to changes in water flow or wind.\n- Educate Pool Users:\n- If others use the pool, make sure they are aware of the importance of not placing chlorine tablets or floaters directly in the skimmer. Educate them on the proper use of floating dispensers.\nBy following these steps, you can ensure that your chlorine floater remains in the pool, providing a consistent release of chlorine without causing damage to your skimmer or pool equipment.", "domain": "chemistry", "round": 3} +{"url": "https://www.witpress.com/elibrary/wit-transactions-on-ecology-and-the-environment/195/34401", "date": "2023-12-09T14:26:38Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100912.91/warc/CC-MAIN-20231209134916-20231209164916-00655.warc.gz", "language_score": 0.8819600939750671, "token_count": 281, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__104372558", "lang": "en", "text": "Combustion Monitoring System On A Natural Gas Fuelled Spark Ignition Engine With High Compression Ratio Using Ionization Current Sensors\nFree (open access)\n209 - 218\nD. Molina, F. Restrepo, I. Bedoya\nThe control of combustion development on spark ignition engines is one of the most important international topics under research today. Engines with high compression ratios have higher thermal efficiency than their similars with low compression ratios but have bigger restrictions on cycle-to-cycle variations and knocking. The monitoring of combustion process is a tool that allows for operating these engines with safer conditions and improving their availability through time. This paper shows the implementation of a combustion monitoring system on a natural gas fuelled spark ignition engine with high compression ratio using ionization current sensors. The implemented methodology consisted of measuring chemical and thermal current ionization from natural gas combustion using the ignition spark plug. The experiments were performed at several power outputs and spark advances. The results obtained from the ionization current system was compared with combustion analysis achieved from in-cylinder pressure measurement with piezo-electric sensor (traditional measurement system). This methodology shows results consistent with those reported in the state of the art and it shown to be a reliable tool for the combustion monitoring on these kinds of engines.\ncombustion engines, ionization current, high compression ratios, in-cylinder pressure, natural gas", "domain": "chemistry", "round": 3} +{"url": "https://www.aiche.org/conferences/videos/conference-presentations/evaluation-alternative-fuels-replace-coal-cement-manufacturing", "date": "2024-04-14T02:31:49Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712296816863.40/warc/CC-MAIN-20240414002233-20240414032233-00137.warc.gz", "language_score": 0.958156943321228, "token_count": 279, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__158762457", "lang": "en", "text": "An operating Portland cement manufacturing plant (Lafarge North America’s Roberta Plant in Calera, Alabama) served as facility for a series of trial burns to replace coal at various substitution rates with bio-based and waste fuels. More than 20 three-day trial burns were conducted from 2007 to 2010 replacing a portion of the coal with scrap tires, waste plastics, woodchips, switch grass, poultry litter, forests trimmings, scrap railroad ties, soy waste products, or waste liquids. Each trial burn contained one or more of the alternative fuels. An elaborate sampling and analysis plan was carried out for each trial burn with close cooperation between the Lafarge plant, the Lafarge testing laboratory, Auburn University, and outside laboratories.\nResults will be presented from a comprehensive evaluation of the raw materials, fuels, clinker, cement, emissions, and plant operations from the test burns. The technically viability for each fuel as supplements for coal for direct burn in a manufacturing plant will be discussed. Alternative Solid Fuel (ASF) handling and process operations were established and evaluated for the use of each of the fuels. Replacement ratios (on a BTU basis) were up to 18% for the waste and bio-based fuels and the synergistic burns where two or more of the alternative materials were used together. Impacts on product quality and emissions were negligible and in some cases advantageous.", "domain": "chemistry", "round": 3} +{"url": "https://www.thermofisher.com/antibody/product/CFLAR-Antibody-Polyclonal/PA5-26132", "date": "2017-01-23T16:07:48Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-04/segments/1484560282932.75/warc/CC-MAIN-20170116095122-00367-ip-10-171-10-70.ec2.internal.warc.gz", "language_score": 0.7767810225486755, "token_count": 586, "dump": "CC-MAIN-2017-04", "global_id": "webtext-fineweb__CC-MAIN-2017-04__0__112970978", "lang": "en", "text": "Note: You clicked on an external link, which has been disabled in order to keep your shopping session open.\n|Tested species reactivity||Human|\n|Host / Isotype||Rabbit / IgG|\n|Immunogen||KLH conjugated synthetic peptide between 145-174 amino acids from the central region of human CFLAR|\n|Purification||Size-exclusion - Dialysis, Ammonium sulfate precipitation|\n|Contains||0.09% sodium azide|\n|Storage Conditions||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C|\n|Tested Applications||Dilution *|\n|Flow Cytometry (Flow)||1:10-1:50|\n|Western Blot (WB)||1:1000|\n* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.\nApoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. It acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. It lacks enzymatic (caspase) activity.\nFor Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.\nc-FLIP; c-FLIPL; c-FLIPR; c-FLIPS; CASH; CASP8AP1; caspase homolog; caspase-eight-related protein; caspase-like apoptosis regulatory protein; caspase-related inducer of apoptosis; Casper; cellular FLICE-like inhibito; cellular FLICE-like inhibitory protein; CLARP; FADD-like anti-apoptotic molecule; FADD-like antiapoptotic molecule 1; FLAME; FLAME-1; FLAME1; FLIP; I-FLICE; inhibitor of FLICE; MACH-related inducer of toxicity; MRIT; testis secretory sperm-binding protein Li 233m; usurpin beta\nc-FLIP; c-FLIPL; c-FLIPR; c-FLIPS; CASH; CASP8AP1; Casper; CFLAR; CLARP; FLAME; FLAME-1; FLAME1; FLIP; I-FLICE; MRIT", "domain": "chemistry", "round": 3} +{"url": "https://www.medshopexpress.com/aveeno-baby-natural-protection-lotion-sunscreen-spf-50-3-ounce", "date": "2023-06-08T06:16:07Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-23/segments/1685224654097.42/warc/CC-MAIN-20230608035801-20230608065801-00420.warc.gz", "language_score": 0.7187918424606323, "token_count": 585, "dump": "CC-MAIN-2023-23", "global_id": "webtext-fineweb__CC-MAIN-2023-23__0__55001163", "lang": "en", "text": "AVEENO Baby Natural Protection Lotion Sunscreen SPF 50 - 3 OUNCE\nAVEENO Baby Natural Protection Lotion Sunscreen SPF 50 - 3 OUNCE0 0.0\n- SKU: 853573755\n- UPC: 38137116450\n- Size: 3 OUNCE\n- Manufacturer: J&J CONSUMER INC\nApply generously and evenly 15 minutes before sun exposure. Reapply: after 80 minutes of swimming or sweating, immediately after towel drying, at least every 2 hours. Sun protection measures: Spending time in the sun increases your risk of skin cancer and early skin aging. To decrease this risk, regularly use a sunscreen with a broad spectrum SPF value of 15 or higher and other sun protection measures including: limit time in the sun, especially from 10 a.m.-2 p.m.; wear long-sleeved shirts, pants, hats, and sunglasses. Children under 6 months of age: Ask a doctor. Protect from excessive heat and direct sun. May stain some fabrics.\nActive Ingredients: Titanium Dioxide 6%; Zinc Oxide 3% Inactive Ingredients: Water; C12-15 Alkyl Benzoate; Cetyl Dimethicone; Styrene Acrylates Copolymer; PEG-8; Beeswax; Dimethylimidazolidinone Rice Starch; Polyamide-5; Butylene Glycol; Ethylhexylglycerin; Glyceryl Stearate; PEG-100 Stearate; Benzyl Alcohol; Dimethicone; Polyhydroxystearic Acid; Arachidyl Alcohol; Caprylyl Glycol; Trisiloxane; Dipropylene Glycol Dibenzoate; Glycerin; Pentylene Glycol; Behenyl Alcohol; Triethoxycaprylylsilane; Xanthan Gum; Citric Acid; Bisabolol; Acrylates/Dimethicone Copolymer; Arachidyl Glucoside; PPG-15 Stearyl Ether Benzoate; Chlorphenesin; Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer; Squalane; Dipotassium Glycyrrhizate; Polyaminopropyl Biguanide; Sodium Citrate; Hydroxyphenyl Propamidobenzoic Acid; Polysorbate 60; Avena Sativa (Oat) Kernel Extract\nFor external use only. Do not use on damaged or broken skin. When using this product keep out of eyes. Rinse with water to remove. Stop use and ask a doctor if rash occurs. Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away.", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/irs1-phospho-y896-peptide-ab5224.html", "date": "2019-10-21T20:42:13Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-43/segments/1570987787444.85/warc/CC-MAIN-20191021194506-20191021222006-00351.warc.gz", "language_score": 0.7493274211883545, "token_count": 443, "dump": "CC-MAIN-2019-43", "global_id": "webtext-fineweb__CC-MAIN-2019-43__0__112100021", "lang": "en", "text": "Product nameIRS1 (phospho Y896) peptide\nSee all IRS1 proteins and peptides\nOur Abpromise guarantee covers the use of ab5224 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\nAdditional notesPositive (ab5224P) and negative (ab5224N) control peptides for the IRS 1 Receptor phospho tyrosine 896 rabbit polyclonal antibody ab4873. Molecular Weight: ab5224P - 1718 ab5224N - 1638 Peptide Content: 80 ± 4% Quantity: 100ug of each peptide.\nConcentration information loading...\nPreparation and Storage\nStability and Storage\nShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.\nConstituent: 0.1% Trifluoroacetic acid\n- HIRS 1\n- Insulin receptor substrate 1\nFunctionMay mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit.\nInvolvement in diseasePolymorphisms in IRS1 may be involved in the etiology of non-insulin-dependent diabetes mellitus (NIDDM) [MIM:125853].\nSequence similaritiesContains 1 IRS-type PTB domain.\nContains 1 PH domain.\nmodificationsSerine phosphorylation of IRS1 is a mechanism for insulin resistance. Ser-312 phosphorylation inhibits insulin action through disruption of IRS1 interaction with the insulin receptor.\nPhosphorylation of Tyr-896 is required for GRB2-binding.\n- Information by UniProt\nab5224 has not yet been referenced specifically in any publications.", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/pancreatic-lipaseptl-antibody-epr6275-ab133556.html", "date": "2019-08-26T00:49:30Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-35/segments/1566027330913.72/warc/CC-MAIN-20190826000512-20190826022512-00309.warc.gz", "language_score": 0.7236751914024353, "token_count": 675, "dump": "CC-MAIN-2019-35", "global_id": "webtext-fineweb__CC-MAIN-2019-35__0__187160875", "lang": "en", "text": "Product nameAnti-Pancreatic Lipase/PTL antibody [EPR6275]\nSee all Pancreatic Lipase/PTL primary antibodies\nDescriptionRabbit monoclonal [EPR6275] to Pancreatic Lipase/PTL\nTested applicationsSuitable for: WB, IHC-Pmore details\nUnsuitable for: IP\nSpecies reactivityReacts with: Human\ncorresponding to Human Pancreatic Lipase/PTL aa 1-100.\n- Human pancreas lysate, Human pancreas tissue\nMouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.\nPreviously labelled as Pancreatic Lipase.\nOur RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents.\nThis product is a recombinant rabbit monoclonal antibody.\nStorage instructionsShipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.\nStorage bufferpH: 7.40\nPreservative: 0.05% Sodium azide\nConstituents: 40% Glycerol, 9.85% Tris glycine, 50% Tissue culture supernatant\nPurityTissue culture supernatant\n- Pathways and Processes\n- Metabolic signaling pathways\n- Lipid and lipoprotein metabolism\n- Lipid metabolism\nOur Abpromise guarantee covers the use of ab133556 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\n|WB||1/10000 - 1/50000. Detects a band of approximately 49 kDa (predicted molecular weight: 51 kDa).|\n|IHC-P||1/100 - 1/250. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.|\nSequence similaritiesBelongs to the AB hydrolase superfamily. Lipase family.\nContains 1 PLAT domain.\n- Information by UniProt\n- lipase, pancreatic antibody\n- LIPP_HUMAN antibody\n- Pancreatic lipase antibody\nAnti-Pancreatic Lipase/PTL antibody [EPR6275] (ab133556) at 1/10000 dilution + Human pancreas lysate at 10 µg\nHRP labelled goat anti-rabbit at 1/2000 dilution\nPredicted band size: 51 kDa\nObserved band size: 49 kDa why is the actual band size different from the predicted?\nab133556 showing negative staining in Normal brain tissue.\nImmunohistochemical analysis of paraffin embedded Human pancreas tissue labelling Pancreatic Lipase/PTL with ab133556 antibody at a dilution of 1/100.\nab133556 showing positive staining in Normal pancreas tissue.\nab133556 has not yet been referenced specifically in any publications.", "domain": "chemistry", "round": 3} +{"url": "https://www.cellsignal.com/products/primary-antibodies/phospho-ask1-ser83-antibody/3761", "date": "2020-06-01T22:33:21Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-24/segments/1590347419639.53/warc/CC-MAIN-20200601211310-20200602001310-00463.warc.gz", "language_score": 0.8893566727638245, "token_count": 453, "dump": "CC-MAIN-2020-24", "global_id": "webtext-fineweb__CC-MAIN-2020-24__0__212230487", "lang": "en", "text": "Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.\nPhospho-ASK1 (Ser83) Antibody detects transfected ASK1 only when phosphorylated at Ser83.\nPolyclonal antibodies are produced by immunizing animals with a synthetic phosphopeptide corresponding to residues around Ser83 of human ASK1. Antibodies are purified by protein A and peptide affinity chromatography.\nApoptosis signal-regulating kinase 1 (ASK1), a MAP kinase kinase kinase, plays essential roles in stress-induced apoptosis (1,2). ASK1 is activated in response to a variety of stress-related stimuli through distinct mechanisms and activates MKK4 and MKK3, which in turn activate JNK and p38 (3). Overexpression of ASK1 activates JNK and p38 and induces apoptosis in several cell types through signals involving the mitochondrial cell death pathway. Embryonic fibroblasts or primary neurons derived from ASK1-/- mice are resistant to stress-induced JNK and p38 activation as well as cell death (4,5). Phosphorylation at Ser967 is essential for ASK1 association with 14-3-3 proteins and suppression of cell death (6). Oxidative stress induces dephosphorylation of Ser967 and phosphorylation of Thr845 in the activation loop of ASK1, both of which are correlated with ASK1 activity and ASK1-dependent apoptosis (7,8). Akt phosphorylates ASK1 at Ser83, which attenuates ASK1 activity and promotes cell survival (9).\nASK1 is a substrate for phosphorylation at Ser83 by Akt, and that this phosphorylation is associated with a decrease in stimulated ASK1 kinase activity (6).\nExplore pathways + proteins related to this product.\nCell Signaling Technology is a trademark of Cell Signaling Technology, Inc.", "domain": "chemistry", "round": 3} +{"url": "https://www.researchwithnj.com/en/publications/cost-effective-soft-actuators-using-nafion-and-carbon-nanotube-el", "date": "2023-12-01T16:27:48Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100290.24/warc/CC-MAIN-20231201151933-20231201181933-00191.warc.gz", "language_score": 0.8607410192489624, "token_count": 280, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__204537578", "lang": "en", "text": "We present the fabrication and characterization of a cost-effective soft actuator capable of bidirectional cantilevered bending in ambientconditions when an electric potentialof4 V is applied. The fabrication procedure is straightforward, minimizes the use of toxic chemicals, and can be executed with common lab equipment. The resulting actuator has a tri-layer construction consisting of a strip of Nafion-117 membrane sandwiched between two multi-walled carbon nanotube (MWCNT) buckypaper electrodes. The buckypaper fabrication was optimized via investigating various combinations of solvents, surfactant, MWCNT concentrations, and layered filtrations, leading to highly conductive and strong buckypaper electrodes. The resultingbuckypaper electrodehadanelectrical resistance of about 10 Ω, which is similar to an industrially synthesizedbuckypaper. Aftersaturating the actuator inan ionic liquidBMIMBF4 (C8H15BF4N2)and applyinga lowvoltage toits electrodes, the actuator responds by bending toward the anode during a period of 20 seconds. The results showed that our 50 mm long actuator (mounted witha cantilevered lengthof40 mm) achieved a maximumtip displacement of28 mm (strain of0.70) and a tip blocking force of0.98 mN.", "domain": "chemistry", "round": 3} +{"url": "http://ebooksmio.com/engineering-technology/31429-conjugated-polymers-theory-synthesis-properties.html", "date": "2013-06-20T08:02:15Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2013-20/segments/1368711005723/warc/CC-MAIN-20130516133005-00042-ip-10-60-113-184.ec2.internal.warc.gz", "language_score": 0.8725638389587402, "token_count": 365, "dump": "CC-MAIN-2013-20", "global_id": "webtext-fineweb__CC-MAIN-2013-20__0__147685339", "lang": "en", "text": "Conjugated Polymers: Theory, Synthesis, Properties, and Characterization by Terje A. Skotheim\nConjugated Polymers: Theory, Synthesis, Properties, and Characterization by Terje A. Skotheim (Repost)\nPublisher: CRC Press | December 26, 2006 | ISBN: 1420043587 | Pages: 1024 | PDF | 30.08 MB\nMany significant fundamental concepts and practical applications have developed since the publication of the best-selling second edition of the Handbook of Conducting Polymers. Now divided into two books, the third edition continues to retain the excellent expertise of the editors and world-renowned contributors while providing superior coverage of recent advances in the chemistry, physics, and materials science of conjugated and conducting organic polymers. Conjugated Polymers: Theory, Synthesis, Properties, and Characterization, the first volume in the set, focuses on the theories, synthetic methods, and basic physical aspects needed to understand the behavior and performance of conjugated polymers. The book initially examines the theories behind p-conjugated materials and electron-lattice dynamics in organic systems. Subsequent chapters detail synthesis methods and electrical and physical properties of the full family of conducting polymers, including polyacetylenes, polyanilines, poly(arylene vinylenes), poly(arylene ethynylenes), and polyheterocycles. Featuring topics central to the science and technology of conducting polymers, this book offers easy access to up-to-date information and provides the basis for the second installment in the set.uploaded.tofilepost.comfilesonic.com\nComments for \"Conjugated Polymers: Theory, Synthesis, Properties, and Characterization by Terje A. Skotheim\"", "domain": "chemistry", "round": 3} +{"url": "https://research-portal.uea.ac.uk/en/publications/evaluation-of-nad-dependent-dna-ligase-of-mycobacteria-as-a-poten", "date": "2024-03-01T03:10:19Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707947474948.91/warc/CC-MAIN-20240301030138-20240301060138-00716.warc.gz", "language_score": 0.9082713723182678, "token_count": 382, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__40860975", "lang": "en", "text": "Mycobacteria contain genes for several DNA ligases, including ligA, which encodes a NAD+-dependent enzyme that has been postulated to be a target for novel antibacterial compounds. Using a homologous recombination system, direct evidence is presented that wild-type ligA cannot be deleted from the chromosome of Mycobacterium smegmatis. Deletions of native ligA in M. smegmatis could be obtained only after the integration of an extra copy of M. smegmatis or Mycobacterium tuberculosis ligA into the attB site of the chromosome, with expression controlled by chemically inducible promoters. The four ATP-dependent DNA ligases encoded by the M. smegmatis chromosome were unable to replace the function of LigA. Interestingly, the LigA protein from M. smegmatis could be substituted with the NAD+-dependent DNA ligase of Escherichia coli or the ATP-dependent ligase of bacteriophage T4. The conditional mutant strains allowed the analysis of the effect of LigA depletion on the growth of M. smegmatis. The protein level of the conditional mutants was estimated by Western blot analysis using antibodies raised against LigA of M. tuberculosis. This revealed that a strong overproduction or depletion of LigA did not affect the growth or survival of mycobacteria under standard laboratory conditions. In conclusion, although NAD+-dependent DNA ligase is essential for mycobacterial viability, only low levels of protein are required for growth. These findings suggest that very efficient inhibition of enzyme activity would be required if NAD+-dependent DNA ligase is to be useful as an antibiotic target in mycobacteria. The strains developed here will provide useful tools for the evaluation of the efficacy of any appropriate compounds in mycobacteria.", "domain": "chemistry", "round": 3} +{"url": "https://en.wikipedia.org/wiki/Ecdysone", "date": "2017-04-25T11:13:12Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-17/segments/1492917120338.97/warc/CC-MAIN-20170423031200-00608-ip-10-145-167-34.ec2.internal.warc.gz", "language_score": 0.8392515182495117, "token_count": 492, "dump": "CC-MAIN-2017-17", "global_id": "webtext-fineweb__CC-MAIN-2017-17__0__300024947", "lang": "en", "text": "(2S,3R,5R,9R,10R,13R,14S,17R)-17- [(2S,3R)-3,6-dihydroxy-6-methylheptan- 2-yl]-2,3,14-trihydroxy-10,13-dimethyl- 2,3,4,5,9,11,12,15,16,17-decahydro- 1H-cyclopenta[a]phenanthren-6-one\n3D model (Jmol)\n|Molar mass||464.63 g/mol|\nExcept where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).\n|what is ?)(|\nEcdysone is a steroidal prohormone of the major insect molting hormone 20-hydroxyecdysone, which is secreted from the prothoracic glands. Insect molting hormones (ecdysone and its homologues) are generally called ecdysteroids. Ecdysteroids act as moulting hormones of arthropods but also occur in other related phyla where they can play different roles. In Drosophila melanogaster, an increase in ecdysone concentration induces the expression of genes coding for proteins that the larva requires, and it causes chromosome puffs (sites of high expression) to form in polytene chromosomes. Ecdysteroids also appear in many plants mostly as a protection agent (toxins or antifeedants) against herbivorous insects. These phytoecdysteroids have been reputed to have medicinal value and are part of herbal adaptogenic remedies like Cordyceps, yet an ecdysteroid precursor in plants has been shown to have cytotoxic properties. A pesticide sold with the name MIMIC has ecdysteroid activity, although its chemical structure has little resemblance to the ecdysteroids.\n- Ecdybase, The Ecdysone Handbook - a free online ecdysteroids database\n- Wang YS, Yang JH, Luo SD, Zhang HB, Li L, Molecules. 2007;12(3):536-42\n|This insect-related article is a stub. You can help Wikipedia by expanding it.|", "domain": "chemistry", "round": 3} +{"url": "https://www.valuewalk.com/tesla-nickel-vs-cobalt-electric-vehicles/", "date": "2024-02-24T16:07:14Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707947474541.96/warc/CC-MAIN-20240224144416-20240224174416-00054.warc.gz", "language_score": 0.9423668384552002, "token_count": 813, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__186881554", "lang": "en", "text": "Electric vehicle powertrains are much more materially diverse than the internal-combustion engine vehicles they replace. As a result, they are putting sudden and unprecedented strain on several raw materials industries.[reit]\nUtilization Of Nickel-Based Batteries In Electric Vehicles\nOne of the most crucial materials is Nickel, an essential part of the cathode in the Li-ion batteries enabling electrification. Most automakers utilize Nickel-based batteries for their balance of energy and power density; for example BMW, Hyundai and Renault use variants of the Lithium Nickel Manganese Cobalt Oxide (NMC) chemistry, while Tesla uses a Lithium Nickel Cobalt Aluminium Oxide (NCA) chemistry. China also now favors NMC chemistries, having phased out Lithium-Iron-Phosphate (LFP) chemistries which is its subsidy program.\nIn 2019, more than 95% of new electric passenger cars sold used a variant of either NMC or NCA, as detailed in the new IDTechEx report “Materials for Electric Vehicles 2020-2030”. Demand for Nickel is further amplified by the trend towards higher Nickel content in cells, as manufacturers switch to chemistries like NMC 622 or 811 over the previous 111 and 523, to improve energy density further and reduce dependence on Cobalt.\nHistoric data from IDTechEx shows a trend towards increasing amounts of high-Nickel content cathodes in electric vehicle batteries. Source: “Materials for Electric Vehicles 2020-2030”.\nNickel is the most expensive material in electric vehicle batteries after Cobalt and is also one of the most highly used outside of the battery industry. While Nickel is often not discussed as much as Cobalt or Lithium, sustainable and environmentally conscious supply is becoming more of an issue.\nIn 2017, the Philippines government suspended nearly half of its Nickel mines, citing environmental concerns. Moreover, Indonesia accounts for the largest supply of Nickel and in 2019 the country banned exports of raw Nickel ore to boost their domestic processing industry. Indonesia also has the most planned developments for increasing Nickel production and is set to dominate the supply chain.\nThe Use Of Deep-Sea Disposal\nOne of the issues is Nickel is typically mined from ores that contain only a very small percentage of useful Nickel, resulting in a large amount of waste material. Recently it has been announced that two Nickel mining companies in Indonesia are planning to use deep-sea disposal for the raw material waste into the Coral Triangle as they ramp up operations. Less than 20 Nickel mines worldwide use deep-sea disposal, but these new facilities would account for millions of tonnes of waste material each year. This method is typically used because it is cheaper than the alternatives of dam storage or converting the raw materials to useful products.\nMany automakers are aware of the environmental concerns in Nickel supply and that it can undermine the environmentally friendly message of the electric vehicle. Most, including the likes of PSA, VW and Tesla, have pledged to reduce the environmental impact of their batteries. This becomes challenging as the choice of suppliers that can meet the demands of these large automotive companies are limited. In the future, Nickel producers will have to prove that their practices are environmentally friendly if they want to sell into the European and American markets, where the automotive industry is making this a priority. Elon Musk has been quoted as saying that Tesla would give a “giant contract” to any companies that could mine Nickel “efficiently and in an environmentally sensitive way” (Financial Times).\nThe market trend is towards NMC622, 811 and NCA chemistries. Source: “Materials for Electric Vehicles 2020-2030”.\nAs the electric vehicle market grows with the trend towards higher Nickel chemistries, IDTechEx expects the demand for Nickel from electric vehicle batteries to increase ten-fold by 2030 compared to 2019. This makes the environmentally-conscious supply of Nickel a serious issue going forward for the electric vehicle market.", "domain": "chemistry", "round": 3} +{"url": "http://su.diva-portal.org/smash/record.jsf?pid=diva2:656908", "date": "2016-10-21T11:21:16Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2016-44/segments/1476988717963.49/warc/CC-MAIN-20161020183837-00334-ip-10-171-6-4.ec2.internal.warc.gz", "language_score": 0.727303683757782, "token_count": 379, "dump": "CC-MAIN-2016-44", "global_id": "webtext-fineweb__CC-MAIN-2016-44__0__8937376", "lang": "en", "text": "Sliding-wear resistance of ultrafine-grained SiC densified by spark plasma sintering with 3Y(2)O(3)+5Al(2)O(3) or Y3Al5O12 additives\n2013 (English)In: Scripta Materialia, ISSN 1359-6462, E-ISSN 1872-8456, Vol. 69, no 8, 598-601 p.Article in journal (Refereed) Published\nThe sliding-wear behavior of ultrafine-grained SiC densified by spark plasma sintering (SPS) with 3Y(2)O(3) + 5Al(2)O(3) or Y3Al5O12 additives was compared to elucidate the effect of the intergranular-phase source. Significantly greater sliding-wear resistance (i.e. lower mild- and severe-wear rates, and delayed mild-to-severe wear transition) is observed with the Y3Al5O12 additive, due to its carbothermal reduction during SPS resulting in a harder YAlO3 phase while reducing the intergranular phase content. Implications for the processing of superior SiC triboceramics are discussed.\nPlace, publisher, year, edition, pages\n2013. Vol. 69, no 8, 598-601 p.\nSiC, Sliding wear, Spark plasma sintering, Ultrafine-grained ceramics\nIdentifiersURN: urn:nbn:se:su:diva-94856DOI: 10.1016/j.scriptamat.2013.07.007ISI: 000324456000009OAI: oai:DiVA.org:su-94856DiVA: diva2:656908", "domain": "chemistry", "round": 3} +{"url": "http://immunoprep.com/catalog-list/873-cusabio/1442-preparation-reagent-antibody-to-horseradish-peroxidase-coupled", "date": "2023-02-03T06:59:08Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-06/segments/1674764500044.16/warc/CC-MAIN-20230203055519-20230203085519-00058.warc.gz", "language_score": 0.779217004776001, "token_count": 351, "dump": "CC-MAIN-2023-06", "global_id": "webtext-fineweb__CC-MAIN-2023-06__0__237067809", "lang": "en", "text": "Catalog number: CSB-PA018664LB01HU-50ul\nFull name: PREP Antibody, HRP conjugated\nDescription : A polyclonal antibody against PREP. Recognizes PREP from Human. This antibody is HRP conjugated. Tested in the following application: ELISA\nSpecifications : Clonality: Polyclonal; Conjugation: HRP conjugated; Host: Rabbit; Isotype: IgG; Immunogen: Recombinant Human Prolyl endopeptidase protein (539-691AA).\nAdditional_information : Form: Liquid; Buffer: Preservative: 0.03% Proclin 300Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Antigen Affinity Purified\nStorage_and_shipping : Upon receipt, store at -20°C or -80°C. Prepare working aliqotes prior to storage to avoid repeated freeze-thaw cycles.\nNotes : For research use only.\nProperties : If you buy Antibodies supplied by Cusabio they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.HRP conjugates are often primary rabbit polyclonal antibodies couples to the enzyme horseradish peroxidase (HRP), found in the roots of horseradish. Also monoclonal HRP conjugates are often used for Western Blot.\nConjugation : HRP Conjugated\nFrench translation : anticorps", "domain": "chemistry", "round": 3} +{"url": "https://scholars.mssm.edu/en/publications/chemical-inhibition-of-the-mitochondrial-division-dynamin-reveals", "date": "2022-12-03T01:51:55Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-49/segments/1669446710918.58/warc/CC-MAIN-20221203011523-20221203041523-00814.warc.gz", "language_score": 0.7980577945709229, "token_count": 250, "dump": "CC-MAIN-2022-49", "global_id": "webtext-fineweb__CC-MAIN-2022-49__0__191925791", "lang": "en", "text": "Mitochondrial fusion and division play important roles in the regulation of apoptosis. Mitochondrial fusion proteins attenuate apoptosis by inhibiting release of cytochrome c from mitochondria, in part by controlling cristae structures. Mitochondrial division promotes apoptosis by an unknown mechanism. We addressed how division proteins regulate apoptosis using inhibitors of mitochondrial division identified in a chemical screen. The most efficacious inhibitor, mdivi-1 (for mitochondrial division inhibitor) attenuates mitochondrial division in yeast and mammalian cells by selectively inhibiting the mitochondrial division dynamin. In cells, mdivi-1 retards apoptosis by inhibiting mitochondrial outer membrane permeabilization. In vitro, mdivi-1 potently blocks Bid-activated Bax/Bak-dependent cytochrome c release from mitochondria. These data indicate the mitochondrial division dynamin directly regulates mitochondrial outer membrane permeabilization independent of Drp1-mediated division. Our findings raise the interesting possibility that mdivi-1 represents a class of therapeutics for stroke, myocardial infarction, and neurodegenerative diseases.", "domain": "chemistry", "round": 3} +{"url": "https://newerasos.com/product/biocap-l-bioremediation-55-gallon-of-over-1-2-trillion-blends-of-bacteria-per-gallon/", "date": "2023-04-01T20:21:15Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-14/segments/1679296950247.65/warc/CC-MAIN-20230401191131-20230401221131-00307.warc.gz", "language_score": 0.8818449974060059, "token_count": 731, "dump": "CC-MAIN-2023-14", "global_id": "webtext-fineweb__CC-MAIN-2023-14__0__129735856", "lang": "en", "text": "Digest & Consume FOG’s while reducing odors in Lift Stations\nOur BioCap-L™ product is a proprietary blend\nof microbes (1 trillion per gallon) specifically designed to operate in the harsh environment found in lift stations that effectively control the build-up of organics and grease while reducing associated odors.\n- Building Service\n- Processing Plants\nContains over 1 Trillion Specific Blends of Microbes per Gallon\n- Reduce float malfunctions\n- Reduce equipment malfunctions\n- Reduce overflow\n- Reduce pumping expenses\n- Reduce Odors\n- Reduce Corrosion Damage\nFeatures and Benefits\n- Resistant to many sanitizing agents\n- Bacteria that Produces Enzymes Naturally\n- Bacteria that naturally digests your lift station waste\n- Bacteria stable in broad pH and varying temperature range\n- Specially designed microbes to survive and perform in harsh environments in lift stations\n- Contains buffers and stimulants for optimal organic reduction of odors and grease\n- Reduces adhesion of F.O.G.’s on surfaces inside lift stations\n- Direct pour into the lift station\n- Dispense into drain lines closest to the lift station\n- Dispense directly into the lift station\n1. BioCap-L™ – 5-gallon pail\n2. Selected applicator\n- Empty gallon container\n- pH: Near Neutral\n- TYPE: Bacterial Blend\n- FORM: Liquid\n- ODOR: Earthy\n- COLOR CHOICE: Green\nBioCap-L™ is a proprietary blend of microbes utilizing only synergistic strains to treat unprocessed hydrocarbons, greases, phenols, and many FOG (fats, oils, greases) compounds. During their polymorphic growth cycle, the vegetative microbes produce enzymes, organic acids, biosurfactants, and biopolymers beneficial for organic digestion and water clarification.\nThis product contains unique catalysts to facilitate the penetration into difficult deposits. A unique organic stabilization is used to extend shelf life until after initial dilution.\nBioCap-L™ should be kept closed when not in use. Store at 59°F to 110°F (15°C to 43.33°C) in a cool, covered area and is not exposed to direct sunlight. This product has a one-year shelf life in an unopened container.\nWash hands thoroughly after handling this product. When handling this product, accepted safety practices should be used. Consult the MSDS before handling.\nBioCap-L™ is shipped as a non-hazardous product, Class 50.\nExcessive Grease and Odors\nUtilize BioCap-L™ in addition to EnCapX Industrial to handle significant grease and odors.\nFlows <100,000 gpd\nDispense 7oz of product daily into drain closest to lift station or directly into lift station.\nFlow > 100,000 gpd\nDispense 10oz of product daily into drain closest to lift station or directly into lift station.\nBioCap-L™ Tips: For additional system efficiency, an aerator and compressor can be installed at the site of the lift station. Bacteria thrive in high-oxygen environments.", "domain": "chemistry", "round": 3} +{"url": "https://gossipsa.com/how-do-you-dispose-of-used-antifreeze/", "date": "2023-03-26T15:45:33Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-14/segments/1679296945473.69/warc/CC-MAIN-20230326142035-20230326172035-00714.warc.gz", "language_score": 0.8762944936752319, "token_count": 326, "dump": "CC-MAIN-2023-14", "global_id": "webtext-fineweb__CC-MAIN-2023-14__0__133762486", "lang": "en", "text": "To safely dispose of old or used antifreeze, keep these rules in mind: Do not pour your waste antifreeze down the drain. Do not pour your antifreeze outside on the ground. Take your old, used, or tainted antifreeze to a local recycling center, service station, or auto parts shop. Click to see full answer. Similarly, you may ask, how do you dispose of antifreeze at home? Steps Contact recycling centers for antifreeze disposal locations. Identify antifreeze that looks dirty or smells like gas. Place tainted and pure waste antifreeze into separate containers. Find hazardous waste disposal centers for tainted antifreeze. Drive the antifreeze to a recycling facility. Also, what fluids does AutoZone recycle? Most AutoZone stores accept used motor oil, transmission fluid, gear oil and automotive batteries. Subsequently, one may also ask, does AutoZone take used antifreeze? Used fluids such as engine oils, transmission fluid, antifreeze and brake fluid are hazardous waste items and must be disposed of properly. In many areas, waste oil, coolant, etc. is being accepted as a part of recycling programs.Does O Reilly’s take used antifreeze?O’Reilly Auto Parts collects used motor oil, automotive batteries, transmission fluid, gear oil and oil filters for recycling — free of charge. It is required that containers are returned to customers. Used antifreeze/coolant is considered hazardous waste so we are unable to recycle it in our stores.", "domain": "chemistry", "round": 3} +{"url": "https://www.metabolomicscentre.nl/node/1284", "date": "2023-01-28T04:41:47Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-06/segments/1674764499470.19/warc/CC-MAIN-20230128023233-20230128053233-00292.warc.gz", "language_score": 0.9092307090759277, "token_count": 404, "dump": "CC-MAIN-2023-06", "global_id": "webtext-fineweb__CC-MAIN-2023-06__0__5384793", "lang": "en", "text": "Untargeted LCMS profiling of semi-polar metabolites followed by metabolite quantitative trait locus (mQTL) analysis was performed in ripe pepper fruits of 113 F2 plants derived from a cross between Capsicum annuum AC1979 (no. 19) and Capsicum chinense No. 4661 Selection (no. 18). The parental accessions were selected based on their variation in fruit morphological characteristics and fruit content of some target phytonutrients. Clear segregation of fruit colour and fruit metabolite profiles was observed in the F2 population. The F2 plants formed three clusters based on their metabolite profiles. Of the total of 542 metabolites, 52 could be annotated, including a range of flavonoids, such as flavone C-glycosides, flavonol O-glycosides and naringenin chalcone, as well as several phenylpropanoids, a capsaicin analogue, fatty acid derivatives and amino acid derivatives. Interval mapping revealed 279 mQTLs in total. Two mQTL hotspots were found on chromosome 9. These two chromosomal regions regulated the relative levels of 35 and 103 metabolites, respectively. Analysis also revealed an mQTL for a capsaicin analogue, located on chromosome 7. Confirmation of flavonoid mQTLs using a set of six flavonoid candidate gene markers and their corresponding expression data (expression QTLs) indicated the Ca-MYB12 transcription factor gene on chromosome 1 and the gene encoding flavone synthase (FS-2) on chromosome 6 as likely causative genes determining the variation in naringenin chalcone and flavone C-glycosides, respectively, in this population. The combination of large-scale metabolite profiling and QTL analysis provided valuable insight into the genomic regions and genes important for the production of (secondary) metabolites in pepper fruit. This will impact breeding strategies aimed at optimising the content of specific metabolites in pepper fruit.", "domain": "chemistry", "round": 3} +{"url": "https://www.unboundmedicine.com/medline/citation/10537078/Differential_changes_in_the_phosphorylation_of_the_protein_kinase_C_substrates_myristoylated_alanine_rich_C_kinase_substrate_and_growth_associated_protein_43/B_50_following_Schaffer_collateral_long_term_potentiation_and_long_term_depression_", "date": "2019-10-23T02:45:40Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-43/segments/1570987828425.99/warc/CC-MAIN-20191023015841-20191023043341-00454.warc.gz", "language_score": 0.8621569871902466, "token_count": 540, "dump": "CC-MAIN-2019-43", "global_id": "webtext-fineweb__CC-MAIN-2019-43__0__175953164", "lang": "en", "text": "Differential changes in the phosphorylation of the protein kinase C substrates myristoylated alanine-rich C kinase substrate and growth-associated protein-43/B-50 following Schaffer collateral long-term potentiation and long-term depression.J Neurochem 1999; 73(5):2175-83JN\nActivation of protein kinase C (PKC) is one of the biochemical pathways thought to be activated during activity-dependent synaptic plasticity in the brain, and long-term potentiation (LTP) and long-term depression (LTD) are two of the most extensively studied models of synaptic plasticity. Here we have examined changes in the in situ phosphorylation level of two major PKC substrates, myristoylated alanine-rich C kinase substrate (MARCKS) and growth-associated protein (GAP)-43/B-50, after pharmacological stimulation or induction of LTP or LTD in the CA1 field of the hippocampus. We find that direct PKC activation with phorbol esters, K+-induced depolarization, and activation of metabotropic glutamate receptors increase the in situ phosphorylation of both MARCKS and GAP-43/B-50. The induction of LTP increased the in situ phosphorylation of both MARCKS and GAP-43/B-50 at 10 min following high-frequency stimulation, but only GAP-43/B-50 phosphorylation remained elevated 60 min after LTP induction. Furthermore, blockade of LTP induction with the NMDA receptor antagonist D-2-amino-5-phosphonopentanoic acid prevented elevations in GAP-43/B-50 phosphorylation but did not prevent the elevation in MARCKS phosphorylation 10 min following LTP induction. The induction of LTD resulted in a reduction in GAP-43/B-50 phosphorylation but did not affect MARCKS phosphorylation. Together these findings show that activity-dependent synaptic plasticity elicits PKC-mediated phosphorylation of substrate proteins in a highly selective and coordinated manner and demonstrate the compartmentalization of PKC-substrate interactions. Key Words: Protein kinase C-Myristoylated alanine-rich C kinase substrate-Growth-associated protein-43-Long-term potentiation-Long-term depression-(RS)-alpha-Methyl-4-carboxyphenylglycine-D-2-Amino-5-ph osphonopentanoic acid-Glutamate.", "domain": "chemistry", "round": 3} +{"url": "https://iubmb.qmul.ac.uk/enzyme/EC4/99/1/10.html", "date": "2022-01-26T08:42:27Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-05/segments/1642320304928.27/warc/CC-MAIN-20220126071320-20220126101320-00656.warc.gz", "language_score": 0.6709804534912109, "token_count": 691, "dump": "CC-MAIN-2022-05", "global_id": "webtext-fineweb__CC-MAIN-2022-05__0__4654576", "lang": "en", "text": "Reaction: (1) chlorophyll a + 2 H+ = pheophytin a + Mg2+\n(2) chlorophyllide a + 2 H+ = pheophorbide a + Mg2+\nFor diagram of reaction click here.\nOther name(s): SGR (gene name); SGRL (gene name); Mg-dechelatase\nSystematic name: chlorophyll a magnesium lyase\nComments: Inhibited by Ca2+, Mg2+ and especially Hg2+. SGR has very low activity with chlorophyllide a and none with chlorophyll b. It acts on chlorophyll a both in its free form and in protein complex. SGRL, on the other hand, is more active with chlorophyllide a than with chlorophyll a. The magnesium formed is scavenged by MCS (metal-chelating substance).\nLinks to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:\n1. Tang, L., Okazawa, A., Fukusaki, E. and Kobayashi, A. Removal of magnesium by Mg-dechelatase is a major step in the chlorophyll-degrading pathway in Ginkgo biloba in the process of autumnal tints. Z. Naturforsch. C 55 (2000) 923-926. [PMID: 11204197]\n2. Costa, M.A., Civello, P.M., Chaves, A.R. and Martínez, G.A. Characterization of Mg-dechelatase activity obtained from Fragaria x ananassa fruit. Plant Physiol. Biochem. 40 (2002) 111-118.\n3. Wang, T., Quisenberry, S.S., Ni, X. and Tolmay, V. Enzymatic chlorophyll degradation in wheat near-isogenic lines elicited by cereal aphid (Homoptera: Aphididae) feeding. J. Econ. Entomol. 97 (2004) 661-667. [PMID: 15154496]\n4. Suzuki, T., Kunieda, T., Murai, F., Morioka, S. and Shioi, Y. Mg-dechelation activity in radish cotyledons with artificial and native substrates, Mg-chlorophyllin a and chlorophyllide a. Plant Physiol. Biochem. 43 (2005) 459-464. [PMID: 15890522]\n5. Kunieda, T., Amano, T. and Shioi, Y. Search for chlorophyll degradation enzyme, Mg-dechelatase, from extracts of Chenopodium album with native and artificial substrates. Plant Sci. 169 (2005) 177-183.\n6. Shimoda, Y., Ito, H. and Tanaka, A. Arabidopsis STAY-GREEN, Mendel’s green cotyledon gene, encodes magnesium-dechelatase. Plant Cell 28 (2016) 2147-2160. [PMID: 27604697]", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/gga1-antibody-ab153799.html", "date": "2020-08-13T00:17:06Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-34/segments/1596439738950.31/warc/CC-MAIN-20200812225607-20200813015607-00279.warc.gz", "language_score": 0.7332654595375061, "token_count": 854, "dump": "CC-MAIN-2020-34", "global_id": "webtext-fineweb__CC-MAIN-2020-34__0__5419767", "lang": "en", "text": "Key features and details\n- Rabbit polyclonal to GGA1\n- Suitable for: WB, IHC-P\n- Reacts with: Human\n- Isotype: IgG\nProduct nameAnti-GGA1 antibody\nSee all GGA1 primary antibodies\nDescriptionRabbit polyclonal to GGA1\nTested applicationsSuitable for: WB, IHC-Pmore details\nSpecies reactivityReacts with: Human\nPredicted to work with: Mouse, Rat, Cow\nRecombinant fragment, corresponding to a region within amino acids 46-307 of Human GGA1.\n- NT2D1, PC-3, U87-MG and SK-N-SH whole cell lysates; Human gastric carcinoma tissue.\nStorage instructionsShipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.\nStorage bufferpH: 7.00\nPreservative: 0.01% Thimerosal (merthiolate)\nConstituents: 78% PBS, 1% BSA, 20% Glycerol\nConcentration information loading...\nPurityImmunogen affinity purified\nOur Abpromise guarantee covers the use of ab153799 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\n|WB||1/500 - 1/3000. Predicted molecular weight: 70 kDa.|\n|IHC-P||1/100 - 1/1000.|\nFunctionPlays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif.\nTissue specificityUbiquitously expressed.\nSequence similaritiesBelongs to the GGA protein family.\nContains 1 GAE domain.\nContains 1 GAT domain.\nContains 1 VHS domain.\nDomainThe VHS domain functions as a recognition module for sorting signals composed of an acidic cluster followed by two leucines (AC-LL motif).\nThe GAT domain is responsible for interaction with ARF-GTP, UBC and RABEP1. Required for recruitment to the TGN it prevents ARF-GTP hydrolysis.\nThe unstructured hinge region contains clathrin-binding but no autoinhibitory (AC-LL) motifs.\nThe GAE domain binds accessory proteins regulating GGAs function.\nmodificationsPhosphorylated by CK2 and dephosphorylated by PP2A. Phosphorylation of GGA1 allows the internal AC-LL motif to bind the VHS domain and to inhibit the recognition of cargo signals. Phosphorylated upon DNA damage, probably by ATM or ATR.\nCellular localizationGolgi apparatus > trans-Golgi network membrane. Endosome membrane.\n- Information by UniProt\n- 4930406E12Rik antibody\n- ADP ribosylation factor binding protein 1 antibody\n- ADP ribosylation factor binding protein GGA1 antibody\nAll lanes : Anti-GGA1 antibody (ab153799) at 1/1000 dilution\nLane 1 : NT2D1 whole cell\nLane 2 : PC-3 whole cell\nLane 3 : U87-MG whole cell\nLane 4 : SK-N-SH whole cell\nLysates/proteins at 30 µg per lane.\nPredicted band size: 70 kDa\n7.5% SDS PAGE\nImmunohistochemical analysis of paraffin-embedded Human gastric carcinoma tissue labeling GGA1 with ab153799 at 1/500 dilution.\nab153799 has not yet been referenced specifically in any publications.", "domain": "chemistry", "round": 3} +{"url": "http://puzzlefactory.pl/en/tags/soil", "date": "2018-11-20T19:53:16Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-47/segments/1542039746639.67/warc/CC-MAIN-20181120191321-20181120213321-00223.warc.gz", "language_score": 0.962921679019928, "token_count": 336, "dump": "CC-MAIN-2018-47", "global_id": "webtext-fineweb__CC-MAIN-2018-47__0__118300919", "lang": "en", "text": "Soil is a mixture of organic matter, minerals, gases, liquids, and organisms that together support life. The Earth's body of soil is the pedosphere, which has four important functions: it is a medium for plant growth; it is a means of water storage, supply and purification; it is a modifier of Earth's atmosphere; it is a habitat for organisms; all of which, in turn, modify the soil. Soil interfaces with the lithosphere, the hydrosphere, the atmosphere, and the biosphere. The term pedolith, used commonly to refer to the soil, literally translates ground stone. Soil consists of a solid phase of minerals and organic matter (the soil matrix), as well as a porous phase that holds gases (the soil atmosphere) and water (the soil solution). Accordingly, soils are often treated as a three-state system of solids, liquids, and gases. Soil is a product of the influence of climate, relief (elevation, orientation, and slope of terrain), organisms, and its parent materials (original minerals) interacting over time. It continually undergoes development by way of numerous physical, chemical and biological processes, which include weathering with associated erosion. Given its complexity and strong internal connectedness, it is considered an ecosystem by soil ecologists. Most soils have a dry bulk density (density of soil taking into account voids when dry) between 1.1 and 1.6 g/cm3, while the soil particle density is much higher, in the range of 2.6 to 2.7 g/cm3.\nCopyright 2018 puzzlefactory.pl. All rights reserved.", "domain": "chemistry", "round": 3} +{"url": "http://www.brainyquote.com/words/eq/equivalent161240.html", "date": "2014-07-13T07:41:46Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2014-23/segments/1404776437232.85/warc/CC-MAIN-20140707234037-00099-ip-10-180-212-248.ec2.internal.warc.gz", "language_score": 0.8958549499511719, "token_count": 415, "dump": "CC-MAIN-2014-23", "global_id": "webtext-fineweb__CC-MAIN-2014-23__0__4280407", "lang": "en", "text": "Equal in wortir or value, force, power, effect, import, and the like; alike in significance and value; of the same import or meaning.\nEqual in measure but not admitting of superposition; -- applied to magnitudes; as, a square may be equivalent to a triangle.\nContemporaneous in origin; as, the equivalent strata of different countries.\nSomething equivalent; that which is equal in value, worth, weight, or force; as, to offer an equivalent for damage done.\nThat comparative quantity by weight of an element which possesses the same chemical value as other elements, as determined by actual experiment and reference to the same standard. Specifically: (a) The comparative proportions by which one element replaces another in any particular compound; thus, as zinc replaces hydrogen in hydrochloric acid, their equivalents are 32.5 and 1. (b) The combining proportion by weight of a substance, or the number expressing this proportion, in any particular compound; as, the equivalents of hydrogen and oxygen in water are respectively 1 and 8, and in hydric dioxide 1 and 16.\nA combining unit, whether an atom, a radical, or a molecule; as, in acid salt two or more equivalents of acid unite with one or more equivalents of base.\nEvery great man, every successful man, no matter what the field of endeavor, has known the magic that lies in these words: every adversity has the seed of an equivalent or greater benefit. W. Clement Stone\nequivalent in Danish is surrogat\nequivalent in Dutch is equivalent, gelijkwaardig\nequivalent in German is gleichwertig, gleichviel, gleichwertig\nequivalent in Italian is equivalente\nequivalent in Norwegian is tilsvarende\nequivalent in Portuguese is equivalente\nequivalent in Spanish is equivalente\nequivalent in Swedish is motsvarande\nShare with your Friends\nEveryone likes a good quote - don't forget to share.", "domain": "chemistry", "round": 3} +{"url": "https://veeprho.com/impurities/mometasone-ep-impurity-j/", "date": "2022-10-04T14:12:56Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-40/segments/1664030337504.21/warc/CC-MAIN-20221004121345-20221004151345-00351.warc.gz", "language_score": 0.6532763242721558, "token_count": 270, "dump": "CC-MAIN-2022-40", "global_id": "webtext-fineweb__CC-MAIN-2022-40__0__147511738", "lang": "en", "text": "1370190-55-8: Mometasone EP Impurity J\nMometasone EP Impurity J (CAS No: 1370190-55-8) or Mometasone Furoate 6α-Methyl is an impurity present in mometasone which is administered for intranasal use in the management of allergic rhinitis. It is also used topically in the treatment of dermatological disorders.\n9, 21-Dichloro-11β-hydroxy-6α, 16α-dimethyl-3, 20-dioxopregna-1, 4-dien-17-yl furan-2-carboxylate\nMometasone BP Impurity J/ Mometasone Furoate 6α-MethylMometasone BP Impurity J/ Mometasone Furoate 6α-Methyl", "domain": "chemistry", "round": 3} +{"url": "http://pubs.rsc.org/en/content/articlelanding/2011/mb/c0mb00026d", "date": "2013-12-13T09:35:54Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2013-48/segments/1386164923389/warc/CC-MAIN-20131204134843-00047-ip-10-33-133-15.ec2.internal.warc.gz", "language_score": 0.9011502861976624, "token_count": 473, "dump": "CC-MAIN-2013-48", "global_id": "webtext-fineweb__CC-MAIN-2013-48__0__12759138", "lang": "en", "text": "Upon genomic insult, the tumor suppressor p53 is phosphorylated and acetylated at specific serine and lysine residues, increasing its stability and transactivation function. Deacetylases, including the type III histone deacetylaseSIRT1, remove acetyl groups from p53 and counterbalance acetyltransferase activity during a DNA damage response. This report describes a series of high-throughput LanthaScreen® time-resolved Förster resonance energy transfer (TR-FRET) immunoassays for detection ofintracellular p53 phosphorylation of Ser15 and acetylation of Lys382 upon treatment with DNA damage agents, such as etoposide. These assays were used to measure the deacetylase activity of SIRT1 and/or Type I/II Histonedeacetylases (HDACs). First, BacMam-mediated overexpression of SIRT1 resulted in dose-dependent deacetylation of GFP-p53 following etoposide treatment of U-2 OS cells, confirming that GFP-p53 serves as a SIRT1 substrate in this assay format. Further, overexpression of the acetyltransferase p300 via BacMam increased the acetylation of GFP-p53 at Lys382. Next, siRNA-mediated knockdown of SIRT1 resulted in increased GFP-p53acetylation, indicating that endogenous SIRT1 activity can also be measured in U-2 OS cells. Consistent with these results, GFP-p53acetylation was also increased upon treatment of cells with a small-molecule inhibitor of SIRT1, EX-527. The effect of this compound was dramatically increased when used in combination with chemotherapeutic drug and/or the HDACinhibitorTrichostatin A, confirming a proposed synergistic mechanism of p53 deacetylation by SIRT1 and Type I/II HDACs. Taken together, the cellular assays described here can be used as high-throughput alternatives to traditional immunoassays such as western blotting for identifying pharmacological modulators of specific p53-modifying enzymes.\nFetching data from CrossRef. This may take some time to load.", "domain": "chemistry", "round": 3} +{"url": "https://www.itech-italia.com/en/applications/dosing-system/", "date": "2020-10-25T05:18:58Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-45/segments/1603107887810.47/warc/CC-MAIN-20201025041701-20201025071701-00124.warc.gz", "language_score": 0.9305053949356079, "token_count": 298, "dump": "CC-MAIN-2020-45", "global_id": "webtext-fineweb__CC-MAIN-2020-45__0__129343010", "lang": "en", "text": "I-Tech offers a range of innovative and high technology dosing systems to mix and combine liquid products such as inks, paints, glazes, coatings or additives, ensuring quality and customized solutions to satisfy every customer’s need.\nThe knowledge gained in over 20 years of activity in many industrial sectors allows I-Tech to guarantee reliable and efficient systems with a simple user interface. Thanks to the innovative algorithm contained in our management software, our dosing systems ensure high precision, extreme rapidity and repeatability of each process.\nI-Tech produces dosing systems in a completely automatic way, suitable for every type of innovative production, supported by a project management that always ensures professionality and high-quality standards.\nAll our systems have been developed to dispense products with a gravimetric principle, so that they can ensure total precision and repeatability in every lot. They are also able to adapt to every production quantity: from small quantities to the large-scale production.\nThe I-Tech dosing systems can be configured both for water-based or solvent-based products and can be combined with different types of storage such as stainless-steel tanks, IBC tanks or drums basing on the production volumes. The dosed product can then be dispensed in flexible quantities within different types of containers.\nIf necessary, the system can be completely customized with different accessories and, if necessary, I-Tech can afford the ATEX or Safety Area version too.", "domain": "chemistry", "round": 3} +{"url": "http://dkoysi.aroma-citadel.ru/rubidium-dating-501.html", "date": "2021-05-06T19:58:03Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-21/segments/1620243988759.29/warc/CC-MAIN-20210506175146-20210506205146-00004.warc.gz", "language_score": 0.9491217732429504, "token_count": 443, "dump": "CC-MAIN-2021-21", "global_id": "webtext-fineweb__CC-MAIN-2021-21__0__119968984", "lang": "en", "text": "And as far as we know, it has been forming in the earth’s upper atmosphere since the atmosphere was made back on Day Two of Creation Week (part of the expanse, or firmament, described in Genesis 1:6–8). Cosmic rays from outer space are continually bombarding the upper atmosphere of the earth, producing fast-moving neutrons (subatomic particles carrying no electric charge) (Figure 1a).1 These fast-moving neutrons collide with atoms of nitrogen-14, the most abundant element in the upper atmosphere, converting them into radiocarbon (carbon-14) atoms.\nCARBON-14 IS CREATED (Figure 1a): When cosmic rays bombard the earth’s atmosphere, they produce neutrons.\nMany people assume that rocks are dated at “millions of years” based on radiocarbon (carbon-14) dating. The most well-known of all the radiometric dating methods is radiocarbon dating.\nCarbon-14 can yield dates of only “thousands of years” before it all breaks down.\nCurrent understanding of the history of life is probably close to the truth because it is based on repeated and careful testing and consideration of data.\nThe rejection of the validity of fossils and of dating by religious fundamentalists creates a problem for them: Fossil sequences were recognized and established in their broad outlines long before Charles Darwin had even thought of evolution.\nOther critics, perhaps more familiar with the data, question certain aspects of the quality of the fossil record and of its dating.\nSome critics, particularly religious fundamentalists, argue that neither fossils nor dating can be trusted, and that their interpretations are better.\nHowever, the principle of carbon-14 dating applies to other isotopes as well.\nPotassium-40 is another radioactive element naturally found in your body and has a half-life of 1.3 billion years.\nAlthough many people think radiocarbon dating is used to date rocks, it is limited to dating things that contain the element carbon and were once alive (like fossils).\nRb)—are not being formed on earth, as far as we know.", "domain": "chemistry", "round": 3} +{"url": "https://greenmedinfo.com/article/paeoniflorin-attenuates-amyloid-beta-peptide-induced-neurotoxicity", "date": "2022-01-20T23:06:34Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-05/segments/1642320302706.62/warc/CC-MAIN-20220120220649-20220121010649-00256.warc.gz", "language_score": 0.8653966784477234, "token_count": 502, "dump": "CC-MAIN-2022-05", "global_id": "webtext-fineweb__CC-MAIN-2022-05__0__151236506", "lang": "en", "text": "Paeoniflorin attenuates amyloid-beta peptide-induced neurotoxicity. - GreenMedInfo Summary\nPaeoniflorin attenuates amyloid-beta peptide-induced neurotoxicity by ameliorating oxidative stress and regulating the NGF-mediated signaling in rats.\nBrain Res. 2013 Mar 1 ;1498:9-19. Epub 2013 Jan 4. PMID: 23295189\nPaeoniflorin is a monoterpene glycoside isolated from the aqueous extract of the dry root of Paeonia. It has been identified to exhibit many pharmacological effects including enhancing the cognitive ability, producing anti-depressant-like effect and reducing the MTPT-induced toxicity. In our previous study, it has shown that paeoniflorin improved the cognitive ability and attenuated the oxidative stress in the Aβ(1-42)-treated rats. In order to further elucidate the possible molecular mechanisms of paeoniflorin on the cognitive ability, rats were injected with Aβ(1-42) (1 μg/μL) and later with paeoniflorin (15 mg/kg and 30 mg/kg, i.p.) and donepezil hydrochloride (2mg/kg, i.p.) daily for 20 days in this study. The results showed that the long-term treatment of paeoniflorin or donepezil enhanced the cognitive performances in the Morris water maze test, restored the decreased activities of superoxide dismutase and catalase and the increased level of malondialdehyde, and reversed the alterations ofmatrix metallopeptidase-9 and tissue-inhibitor of metalloproteinase-1 in the hippocampus of Aβ(1-42)-treated rats. Paeoniflorin also up-regulated the activity of choline acetyltrasferase and the expression of tyrosine kinase A receptor, and down-regulated the activity of acetylcholine esterase in the hippocampus of Aβ(1-42)-treated rats. These results demonstrate that paeoniflorin ameliorates the spatial learning and memory deficits by attenuating oxidative stress and regulating the nerve growth factor-mediated signaling to reinforce cholinergic functions in the hippocampus of the Aβ(1-42)-treated rats.", "domain": "chemistry", "round": 3} +{"url": "https://www.rjptonline.org/AbstractView.aspx?PID=2021-14-3-107", "date": "2022-11-30T07:21:42Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-49/segments/1669446710733.87/warc/CC-MAIN-20221130060525-20221130090525-00305.warc.gz", "language_score": 0.6878349781036377, "token_count": 2209, "dump": "CC-MAIN-2022-49", "global_id": "webtext-fineweb__CC-MAIN-2022-49__0__188385654", "lang": "en", "text": "Susanta Paul, Tathagata Roy, Anannya Bose, Debasmita Chatterjee, Victor Roy Chowdhury, Meghamouli Rana, Ashmita Das\nSusanta Paul1*, Tathagata Roy1, Anannya Bose2, Debasmita Chatterjee1, Victor Roy Chowdhury1, Meghamouli Rana1, Ashmita Das3\n1Department of Pharmaceutical Technology, JIS University, Agarpara, Kolkata, India.\n2Seacom Pharmacy College, Sankrail, Howrah, India.\n3Department of Pharmacy, Guru Ghasidas Vishwavidyalaya (A Central University), Koni, Bilaspur, India.\nVolume - 14,\nIssue - 3,\nYear - 2021\nLiposomes are the sphere-shaped vesicles consisting of one or more phospholipid bilayers. Structurally the liposomal vesicles are the bilayered vesicles that consist of a core of aqueous solution and a lipid spheres that contain no aqueous material. They are generally made up of phospholipids. Liposomal drug delivery systems have been widely used in pulmonary drug delivery for multiple applications which includes optimum solubilization of active pharmaceutical agents, prolonged period of drug release. Moreover, the site avoidance and site-specific drug targeting therapy could be achieved by the liposomal drug delivery system, to inhibit the tissue toxicity of many potent drug substances. In this present review, formulation aspects of liposomes, various aerosolization methods and the characterization methods of liposome formulation and an extensive overview of the use of liposomes as a pulmonary drug delivery system for the treatment of diseases like tuberculosis and lung cancer and are discussed. Liposomes can be used as a successful drug carrier in the fields like lung infection, tumor targeting, genetic transfer, immunomodulation, skin, and topical therapy.\nCite this article:\nSusanta Paul, Tathagata Roy, Anannya Bose, Debasmita Chatterjee, Victor Roy Chowdhury, Meghamouli Rana, Ashmita Das. Liposome Mediated Pulmonary Drug Delivery System: An updated Review. Research J. Pharm. and Tech 2021; 14(3):1791-1796. doi: 10.5958/0974-360X.2021.00318.8\nSusanta Paul, Tathagata Roy, Anannya Bose, Debasmita Chatterjee, Victor Roy Chowdhury, Meghamouli Rana, Ashmita Das. Liposome Mediated Pulmonary Drug Delivery System: An updated Review. Research J. Pharm. and Tech 2021; 14(3):1791-1796. doi: 10.5958/0974-360X.2021.00318.8 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2021-14-3-107\n1. Bakowsky H, Richter T, et al. Adhesion characteristics and stability assessment of lectin-modified liposomes for site-specific drug delivery. Biochim Biophys Acta. 2008; 1778: 242–249.\n2. Gaspar MM, Bakowsky U, Ehrhardt C. Inhaled liposomes- current strategies and future challenges. J Biomed Nanotechnology. 2008; 4: 245–257.\n3. Bangham AD, Horne RW, et al. Negative staining of phospholipids and their structural modification by surface-active agents as observed in the electron Microscope. J Mol Biol. 1964; 8: 660-668.\n4. Mozafari MR. Liposomes: an overview of manufacturing techniques. Cell Mol Biol Lett. 2005; 10: 711-719.\n5. Agarwal R, Katare OP, Vyas SP. Preparation and in vitro evaluation of liposomal/ niosomal delivery systems for anti-psoriatic drug dithranol. Int J Pharm. 2001; 228(1-2): 43-52.\n6. Hamilton RL, Goerke J, Guo L. Unilamellar liposomes made with the French pressure cell: A simple preparative and semi-quantitative technique. J Lipid Res. 1980; 21: 981-992.\n7. Johnston MJ, Semple SC, Klimuk SK, Ansell S, Maurer N, Cullis PR. Characterization of the drug retention and pharmacokinetic properties of liposomal nanoparticles containing dihydrosphingomyelin. Biochim Biophys Acta. 2007; 1768: 1121–1127.\n8. Sharma A, Sharma US. Liposomes in drug delivery: progress and limitations. Int J Pharm. 1997; 154: 123-140.\n9. Andresen TL, Davidsen J, Begtrup M, Mouritsen OG, Jørgensen K. Enzymatic release of antitumor ether lipids by specific phospholipase A2 activation of liposome-forming prodrugs. J. Med. Chem. 2004; 47: 1694–1703.\n10. Antohe F, Lin L, Kao GY, Poznansky MJ, Allen TM. Transendothelial movement of liposomes in vitro mediated by cancer cells, neutrophils or histamine. J. Liposome Res. 2004; 14: 1–25.\n11. Bozzuto G, Molinari A. Liposomes as nanomedical devices. Int. J. Nanomedicine. 2015; 10: 975–999.\n12. Deshpande PP, Biswas S, Torchilin VP. Current trends in the use of liposomes for tumor targeting. Nanomedicine (Lond). 2013; 8: 1509–1528.\n13. Ding BS, Dziubla T, Shuvaev VV, Muro S, Muzykantov VR. Advanced drug delivery systems that target the vascular endothelium. Mol. Interv. 2006; 6: 98–112.\n14. Han XJ, Wei YF, Wan YY, Jiang LP, Zhang JF, Xin HB. Development of a novel liposomal nanodelivery system for bioluminescence imaging and targeted drug delivery in ErbB2-overexpressing metastatic ovarian carcinoma. Int. J. Mol. Med. 2014; 34: 1225–1232.\n15. Barker AF, O’Donnell AE, Flume P, Thompson PJ, Ruzi JD, De Gracia J, Boersma WG, De Soyza A, Shao L, Zhang J, et al. Aztreonam for inhalation solution in patients with non-cystic fibrosis bronchiectasis (AIR-BX1 and AIR-BX2): Two randomised double-blind, placebo-controlled phase 3 trials. Lancet Respir. Med. 2014; 2: 738–749.\n16. Haworth CS, Foweraker JE, Wilkinson P, Kenyon RF, Bilton D. Inhaled colistin in patients with bronchiectasis and chronic Pseudomonas aeruginosa infection. Am. J. Respir. Crit. Care Med. 2014; 189: 975–982.\n17. Grimwood K, Bell SC, Chang AB. Antimicrobial treatment of non-cystic fibrosis bronchiectasis. Expert Rev. Anti-Infect. Ther. 2014; 12: 1277–1296.\n18. Chalmers JD, Smith MP, McHugh BJ, Doherty C, Govan JR, Hill AT. Short- and long-term antibiotic treatment reduces airway and systemic inflammation in non-cystic fibrosis bronchiectasis. Am. J. Respir. Crit. Care Med. 2012; 186: 657–665.\n19. Adjemian J, Olivier KN, Seitz AE, Holland SM, Prevots DR. Prevalence of nontuberculosis mycobacterial lung disease in US Medicare beneficiaries. Am. J. Respir. Crit. Care Med. 2012; 185: 881–886.\n20. Rose SJ, Neville ME, Gupta R, Bermudez LE. Delivery of Aerosolized Liposomal Amikacin as a Novel Approach for the Treatment of Nontuberculous Mycobacteria in an Experimental Model of Pulmonary Infection. PLoS ONE. 2014; 9: e108703.\n21. Bermudez LE, Blanchard JD, Hauck L, Gonda I. Treatment of Mycobacterium avium subsp hominissuis (MAH) lung infection with liposome-encapsulated ciprofloxacin resulted in significant decrease in bacterial load in the lung. Am J Respir Crit Care Med. 2015; 191: A6293.\n22. Meers P, Neville M, Malinin V, Scotto AW, Sardaryan G, Kurumunda R, Mackinson C, James G, Fisher S, Perkins WR. Bio-film penetration, triggered release and in vivo activity of inhaled liposomal amikacin in chronic Pseudomonas aeruginosa lung infections. J. Antimicrob. Chemo. 2008; 61: 859–868.\n23. Cipolla D, Gonda I, Chan HK. Liposomal Formulations for Inhalation. Ther. Deliv. 2013; 4: 1047–1072.\n24. Wong JP, Yang H, Blasetti KL, Schnell G, Conley J, Schofield LN. Liposome Delivery of Ciprofloxacin against Intracellular Francisellatularensis Infection. J. Control. 2003; 92: 265–273.", "domain": "chemistry", "round": 3} +{"url": "http://ktjdatingdm.sbh-online.xyz/ultrabac-7-msds-sheets.html", "date": "2020-04-08T17:46:17Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-16/segments/1585371821680.80/warc/CC-MAIN-20200408170717-20200408201217-00165.warc.gz", "language_score": 0.7603946924209595, "token_count": 1343, "dump": "CC-MAIN-2020-16", "global_id": "webtext-fineweb__CC-MAIN-2020-16__0__167606835", "lang": "en", "text": "Ultrabac 7 msds sheets\nIndividual composition of. ultrabac Note: This MSDS covers many types of sand and gravel. Handling and Storage. sheets When your team is in the field they can access a full database of material safety data sheets up to date MSDSs from any mobile device. Identification Material name: DYMONIC FC WHITE. Material Safety Data Sheet MSDS 2.\nOur msds MSDS Management software is accessible on smartphones tablets, computers. novyi, gas- msds gangrene caused msds by Cl. This material safety ultrabac data sheet and the information contained herein were not developed sheets for abrasive blasting. sheets MATERIAL SAFETY DATA SHEET _ _ _ _ _ Material Name: Clostridium Chauvoei- msds Septicum- Novyi- Sordelli- Perfringens Types C& D Bacterin- Toxoid Revision date: 07- Dec- Page 7 of 7 Version: 1. Butyl benzyl phthalate% Calcium Carbonate ( Limestone%. Go mobile sheets to reduce time and money with the easiest MSDS management system in the industry.\nFor use in healthy cattle sheep as an aid in preventing blackleg ultrabac caused by Clostridium chauvoei malignant edema caused by Cl. 21 day slaughter withdrawal. Ultrabac 7 Indications. Precaution( s) : Store at 2° - 7° C. Ultrabac 7 msds sheets. The search field uses a full word search to identify return exact matches to product name, , manufacturer product code. REGULATORY INFORMATION 16. Ultrabac 7 7/ Somubac is a msds 7- way cattle vaccine that aids in msds the sheets prevention of blackleg in cattle calves 3 months of age older. Annual revaccination with a sheets single dose is sheets recommended. A safety data sheet ( SDS) , health for the use of various substances , material safety data sheets sheet ( MSDS), product safety data sheets sheet ( PSDS) is a ultrabac document that lists information relating to occupational safety products. co cept O material safety data sheet clean o green o h 7 p. Sheep: Aseptically administer 1 mL subcutaneously, followed by a second dose 4- 6 weeks later.\nOTHER INFORMATION Data sheets Sources: The data contained in this MSDS may have been gathered from confidential internal sources raw material suppliers, from the published literature. In the GHS they serve the sheets same function that the Material Safety Data msds Sheet MSDS does in OSHA' s HazCom Standard. Caution( s) : As with many vaccines, anaphylaxis may occur after use. Use entire contents when first opened. Updated Section 6 - Accidental msds Release Measures. ( July 31 ), Clarification of OSHA' s Hazard Communication Standard with regards to the carcinogenicity of wood dust ultrabac ( Oct 11 1995). to ISO/ DIS 11014 ultrabac Printing date 08/ 01/ Reviewed on 08/ 01/ msds DR 1 Identification of substance Product details Trade name: R562 Sn62Pb36Ag2 Sn60Pb38Ag2 Sn62. Directions For msds Use. CPH MSDS NA 1 / 6 MATERIAL SAFETY DATA SHEET 1. 5 Application of msds the substance / msds the preparation: ultrabac Solder paste. OSHA' s hazard communication requirements for the wood ultrabac products you sell ( Dec 5, 1994). : 1 of 6 Electronically generated document - no signature required. SAFETY DATA SHEET _ _ _ _ _ 15.\nRevision date: 07- Dec- Page 1 of 7 MATERIAL SAFETY DATA SHEET Version: 1. Requirements for ultrabac labels msds and material safety data sheets for distributors of lumber. Identification Material name: TREMCO 830 CLEAR Material: Recommended use and restriction on use. IDENTIFICATION OF THE SUBSTANCE/ PREPARATION AND THE COMPANY/ ultrabac UNDERTAKING Material Name: Clostridium Chauvoei- Septicum- Novyi- Sordelli- Perfringens Types C& D Bacterin- Toxoid Trade Name: Ultrabac( R) 7 Chemical Family: Mixture Intended Use: Veterinary Vaccine 2. Daimlerstraße 1 VARTA Microbattery GmbH. sheets Product and Company Identification Material name CIDEX Activated Dialdehyde Solution. SAFETY DATA SHEET 1. Safety Data Sheets are ultrabac ultrabac an essential component of the GHS are intended to provide comprehensive information about a substance mixture for use in workplace chemical management.\nReasons for Revision: Updated Section 1 - Identification ultrabac of the Substance/ Preparation msds and the Company/ Undertaking. sheets sordellii , enterotoxemia enteritis caused by Cl. Handling and storage septicum, black disease caused by Cl. perfringens types B , C D. Page 1/ 7 Material Safety Data Sheet acc. Verify words are msds entered exactly as intended The word 7 search will only return exact matches for the criteria specified.\nUltrabac 7 msds sheets. OTHER INFORMATION Reasons ultrabac for Revision: Updated Section 3 - Hazard Identification. EXO ultrabac is pleasantly perfumed and 7 leaves a freshly cleaned fragrance to rooms. DO NOT use this product for abrasive blasting.\nSafety Data Sheet is accurate, and while it is provided in good faith, it is without a warranty of any kind, expressed or implied. 00 - Clostridium Chauvoei- Septicum- Novyi- Sordelli- Perfringens Types C& D Bacterin- Toxoid Pfizer Inc. Carbon black ( 2- 7% ) Polypropylene wax ( 0. 5- 3% ) Amorphous Silica treated with dimethylsilicone ( 0. 1- 2% ) CAS# Section II - Emergency and First Aid Primary Route of Entry: Symptoms of Overexposure: Inhalation Eyes: Minimal respiratory tract irritation may occur as with exposure to large.\nultrabac 7 msds sheets\nUltrabac 7/ Somubac vaccine for use in healthy cattle and calves 3 months of age or older. For prevention of diseases caused by 7 types of Clostridial organisms and Haemophilus somnus.", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/nell1-antibody-ab154561.html", "date": "2020-06-07T04:23:15Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-24/segments/1590348523476.97/warc/CC-MAIN-20200607013327-20200607043327-00231.warc.gz", "language_score": 0.671818733215332, "token_count": 548, "dump": "CC-MAIN-2020-24", "global_id": "webtext-fineweb__CC-MAIN-2020-24__0__129775032", "lang": "en", "text": "Product nameAnti-NELL1 antibody\nSee all NELL1 primary antibodies\nDescriptionRabbit polyclonal to NELL1\nTested applicationsSuitable for: WB, IHC-Pmore details\nSpecies reactivityReacts with: Human\nPredicted to work with: Mouse, Rat\nRecombinant fragment corresponding to a region within amino acids 50-505 of Human NELL1 (Uniprot ID: Q92832).\n- NT2D1 and IMR32 whole cell lysates, Human breast ca tissue\nStorage instructionsShipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.\nStorage bufferpH: 7.00\nPreservative: 0.01% Thimerosal (merthiolate)\nConstituents: 1.21% Tris, 0.75% Glycine, 20% Glycerol\nConcentration information loading...\nPurityImmunogen affinity purified\nOur Abpromise guarantee covers the use of ab154561 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\n|WB||1/500 - 1/3000. Predicted molecular weight: 90 kDa.|\n|IHC-P||1/100 - 1/1000. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. Or perform heat mediated antigen retrieval with Tris-EDTA buffer pH 8.|\nFunctionInvolved in the control of cell growth and differentiation.\nSequence similaritiesContains 6 EGF-like domains.\nContains 1 TSP N-terminal (TSPN) domain.\nContains 5 VWFC domains.\n- Information by UniProt\n- FLJ45906 antibody\n- IDH3GL antibody\n- NEL like 1 (chicken) antibody\nAll lanes : Anti-NELL1 antibody (ab154561) at 1/5000 dilution\nLane 1 : NT2D1 whole cell lysate\nLane 2 : IMR32 whole cell lysate\nLysates/proteins at 30 µg per lane.\nPredicted band size: 90 kDa\n7.5% SDS PAGE\nImmunohistochemical analysis of paraffin-embedded Human breast ca tissue labeling NELL1 using ab154561 at a 1/250 dilution.\nab154561 has not yet been referenced specifically in any publications.", "domain": "chemistry", "round": 3} +{"url": "https://link.springer.com/article/10.1023%2FB%3AGLAC.0000026777.25013.59", "date": "2017-08-18T20:34:20Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-34/segments/1502886105108.31/warc/CC-MAIN-20170818194744-20170818214744-00169.warc.gz", "language_score": 0.7813475131988525, "token_count": 271, "dump": "CC-MAIN-2017-34", "global_id": "webtext-fineweb__CC-MAIN-2017-34__0__74822902", "lang": "en", "text": "The Effect of Argon Plasma on Reduction of Variable-Valence Oxides in Synthesis of Minerals\n- 33 Downloads\nThe results of studying plasma treatment of chromium, titanium, and iron oxides are discussed. It is demonstrated that variable-valence oxides become partly reduced in argon plasma.\n- 1.N. I. Min'ko, V. S. Bessmertnyi, and P. S. Dyumina, “Use of alternative power sources in technology of glass and glass ceramics,” Steklo Keram., No. 6, 3-5 (2002).Google Scholar\n- 2.V. S. Bessmertnyi, V. S. Lesovik, V. P. Krokhin, et al., “The reducing nature of argon in plasma treatment of high-melting nonmetallic materials,” Steklo Keram., No. 10, 30-32 (2001).Google Scholar\n- 3.V. S. Gorshkov, V. V. Timashev, and V. G. Savel'ev, Methods for Physicochemical Analysis of Binding Materials [in Russian], Vysshaya Shkola, Moscow (1981).Google Scholar\n© Plenum Publishing Corporation 2004", "domain": "chemistry", "round": 3} +{"url": "https://www.ars.usda.gov/research/publications/publication/?seqNo115=283337", "date": "2023-09-30T01:56:56Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233510575.93/warc/CC-MAIN-20230930014147-20230930044147-00127.warc.gz", "language_score": 0.8937900066375732, "token_count": 539, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__315562954", "lang": "en", "text": "Submitted to: Journal of Cotton Science\nPublication Type: Peer Reviewed Journal\nPublication Acceptance Date: 3/17/2015\nPublication Date: 8/4/2015\nCitation: Fortier, C.A., Rodgers III, J.E., Foulk, J.A. 2015. Botanical trash mixtures analyzed with near-infrared and attenuated total reflectance fourier transform spectroscopy and thermogravimetric analysis. Journal of Cotton Science. p. 603-612.\nInterpretive Summary: Botanical trash mixtures are usually found comingled with cotton lint reducing its profitability and complicating its later processing. Three methods, near-infrared (NIR) and attenuated total reflectance Fourier Transform infrared (ATR/FT-IR) spectroscopy as well as thermogravimetric analysis (TGA), were used to analyze binary botanical trash mixtures of hull and leaf, hull and seed coat, hull and stem, leaf and seed coat, leaf and stem, and stem and seed coat. The results show that NIR could be successfully used to identify raw trash mixtures, ATR/FT-IR was more suited to identifying powder-sized trash mixtures, and TGA could be used to identify pure and binary trash mixtures. These methods show the applicability of alternative methods to identify fiber properties, like trash, as opposed to the conventionally used Uster ® High Volume Instrument (HVI) and the Shirley Analyzer.\nTechnical Abstract: Botanical cotton trash mixed with lint reduces cotton’s marketability and appearance. During cotton harvesting, ginning, and processing, trash size reduction occurs, thus complicating its removal and identification. This trash causes problems by increasing ends down in yarn formation and thus processing efficiency. The Uster ® High Volume Instrument (HVI™) and Shirley Analyzer are extensively used to determine trash levels in cotton lint, but they do not specifically identify its origin. This study was performed to determine the potential for recognizing differences between botanical cotton trash mixtures via Near-Infrared (NIR) spectroscopy and Attenuated Total Reflectance-Fourier Transform Infrared (ATR/FT-IR) spectroscopy, and Thermogravimetric Analysis (TGA). A “proof of concept” was demonstrated that shows the promise of NIR and ATR-FTIR spectroscopy along with TGA to be employed to identify binary mixtures of botanical cotton trash. The results of this study are presented herein.", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/znt-7-antibody-ab224405.html", "date": "2020-10-22T10:06:43Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-45/segments/1603107879362.3/warc/CC-MAIN-20201022082653-20201022112653-00578.warc.gz", "language_score": 0.7372572422027588, "token_count": 847, "dump": "CC-MAIN-2020-45", "global_id": "webtext-fineweb__CC-MAIN-2020-45__0__152288313", "lang": "en", "text": "Key features and details\n- Rabbit polyclonal to ZnT-7\n- Suitable for: IHC-P, ICC/IF, WB\n- Reacts with: Human\n- Isotype: IgG\nProduct nameAnti-ZnT-7 antibody\nSee all ZnT-7 primary antibodies\nDescriptionRabbit polyclonal to ZnT-7\nTested applicationsSuitable for: IHC-P, ICC/IF, WBmore details\nSpecies reactivityReacts with: Human\nPredicted to work with: Cow\n- WB: ZnT-7 over-expression - HEK-293T whole cell lysate; IHC-P: Human small intestine tissue; ICC: A431 cells.\nPreviously labelled as SLC30A7.\nStorage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.\nStorage bufferpH: 7.20\nPreservative: 0.02% Sodium azide\nConstituents: 40% Glycerol (glycerin, glycerine), PBS\nConcentration information loading...\nPurityImmunogen affinity purified\nOur Abpromise guarantee covers the use of ab224405 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\n|IHC-P||1/50 - 1/200. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.|\n|ICC/IF||Use a concentration of 0.25 - 2 µg/ml.\nFixation/Permeabilization: PFA/Triton X-100.\n|WB||Use a concentration of 0.04 - 0.4 µg/ml. Predicted molecular weight: 42 kDa.|\nFunctionSeems to facilitate zinc transport from the cytoplasm into the Golgi apparatus. Partly regulates cellular zinc homeostasis. Required with ZNT5 for the activation of zinc-requiring enzymes, alkaline phosphatases (ALPs). Transports zinc into the lumens of the Golgi apparatus and the vesicular compartments where ALPs locate, thus, converting apoALPs to holoALPs. Required with ZNT5 and ZNT6 for the activation of TNAP.\nSequence similaritiesBelongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.\nCellular localizationGolgi apparatus > trans-Golgi network membrane.\n- Information by UniProt\n- 1810059J10Rik antibody\n- 2610034N15Rik antibody\n- 4833428C12Rik antibody\nAll lanes : Anti-ZnT-7 antibody (ab224405) at 0.4 µg/ml\nAll lanes : ZnT-7 over-expression - HEK-293T whole cell lysate, Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa)\nPredicted band size: 42 kDa\nImmunohistochemical analysis of human small intestine tissue labeling ZnT-7 in the luminal membrane of glandular cells with ab224405 at 1/50 dilution.\nPerformed heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.\nImmunofluorescent analysis of A431 (human epidermoid carcinoma cell line) cells labeling ZnT-7 (green) in Golgi apparatus with ab224405 at 2 µg/ml.\nTo our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.\nab224405 has not yet been referenced specifically in any publications.", "domain": "chemistry", "round": 3} +{"url": "https://lnu.se/en/staff/narges.razmjoo/", "date": "2018-07-19T19:31:51Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-30/segments/1531676591216.51/warc/CC-MAIN-20180719183926-20180719203926-00476.warc.gz", "language_score": 0.6764217615127563, "token_count": 504, "dump": "CC-MAIN-2018-30", "global_id": "webtext-fineweb__CC-MAIN-2018-30__0__199231565", "lang": "en", "text": "Article in journal (Refereed)\n- Finnerman, O., Razmjoo, N., Guo, N., Strand, M., Ström, H. (2017). Reactor modelling assessment for urea-SNCR applications. International journal of numerical methods for heat & fluid flow. 27. 1395-1411.\n- Razmjoo, N., Sefidari, H., Strand, M. (2016). Measurements of temperature and gas composition within the burning bed of wet woody residues in a 4 MW moving grate boiler. Fuel processing technology. 152. 438-445.\n- Sefidari, H., Razmjoo, N., Strand, M. (2014). An experimental study of combustion and emissions of two types of woody biomass in a 12-MW reciprocating-grate boiler. Fuel. 135. 120-129.\n- Razmjoo, N., Sefidari, H., Strand, M. (2014). Characterization of hot gas in a 4 MW reciprocating grate boiler. Fuel processing technology. 124. 21-27.\nConference paper (Refereed)\n- Razmjoo, N., Strand, M. (2017). Investigation of moist fuel bed combustion in grate furnaces. Proceedings of Nordic Flame Days, 10-11 October, 2017, Stockholm.\n- Razmjoo, N., Strand, M. (2017). In-bed combustion charachteristics of wet wood chips and sawdust in a full-scale grate boiler. Proceedings 13th International Conference on Energy for a Clean Environment.\n- Razmjoo, N., Sefidari, H., Strand, M. (2015). Experimental investigation of fuel bed combustion in an industrial grate boiler. .\n- Razmjoo, N., Hermansson, S., Strand, M. (2015). Characterization of the fuel bed combustion of wood residues in a 4 MW grate boiler. European Biomass Conference and Exhibition Proceedings. 741-744.\n- Razmjoo, N., Sefidari, H., Strand, M., Yang, J. (2013). Gas measurements and characterization of wood combustion in a traveling grate boiler. Proceedings for 21st European Biomass Conference and Exhibition. 591-594.\nDoctoral thesis, comprehensive summary (Other academic)", "domain": "chemistry", "round": 3} +{"url": "https://www.hindawi.com/journals/bmri/2010/497219/fig1/", "date": "2017-03-27T01:04:38Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-13/segments/1490218189316.33/warc/CC-MAIN-20170322212949-00306-ip-10-233-31-227.ec2.internal.warc.gz", "language_score": 0.9623759984970093, "token_count": 555, "dump": "CC-MAIN-2017-13", "global_id": "webtext-fineweb__CC-MAIN-2017-13__0__239509710", "lang": "en", "text": "Figure 1: Characterization of SHIV 89.6 VLPs. SHIV 89.6 VLPs were produced by coinfection of Sf9 cells with rBVs expressing HIV 89.6 Env and SIVmac239 Gag proteins at the MOI (multiplicity of infection) of 5 and 2, respectively, and purified as described in Section 2. SIV Gag VLPs were produced by infection of Sf9 cells with rBV expressing SIVmac239 Gag proteins and purified similarly. (a) Characterization of SHIV 89.6 VLPs by Western blot. 5 total proteins were taken from each VLP preparation and analyzed by SDS-PAGE followed by Western blot using rabbit-anti-gp120 antibody for detection of HIV Env proteins and monkey-anti-SIV fordetection of the SIV Gag proteins. Lanes 1, SHIV 89.6 VLP; 2, SIV Gag-only VLP. (b) Comparison of HIV 89.6 Env amount in VLP preparations by a quantitative ELISA. The amount of HIV Env proteins in SHIV 89.6 VLP preparations was determined by a sandwich ELISA. ELISA plates were coated with a sheep-anti-gp120 antibody as the capture antibody, followed by addition of serial 2-fold dilutions of SHIV 89.6 VLPs lysed by 1% Triton X-100. The amount of HIV Env bound to the plate was then detected by sera from HIV-infected patients as the detecting antibody, followed by addition of HRP-conjugated Goat-antihuman antibody and development of color. Lysed SIVmac239 Gag VLPs were used as controls. A standard curve for the amount of HIV Env was obtained by adding purified HIV 89.6 Gp120 mixed with SIVmac239 Gag VLP lysed by 1% Triton X-100 to the sheep-anti-gp120 antibody-coated ELISA plate. The amount of HIV Env proteins was then calculated based on the obtained standard curve and then expressed as nanograms (ng) of HIV Env in 1 VLP preparation. VLP1, VLP2, and VLP3 represent SHIV 89.6 VLPs produced from three different batches and Gag-VLP represents the control SIVmac239 Gag only VLP preparation. (c) Negative staining and EM examination of SHIV 89.6 VLPs. Purified SHIV 89.6 VLPs were stained with 1% uranyl acetate followed by examination under a transmission electron microscope.", "domain": "chemistry", "round": 3} +{"url": "https://xtremepharmacy.co.uk/products/dettol-2-in-1-travel-wipes-small-15-wipes-small", "date": "2024-03-04T19:23:00Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707947476464.74/warc/CC-MAIN-20240304165127-20240304195127-00869.warc.gz", "language_score": 0.8467705845832825, "token_count": 257, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__91924985", "lang": "en", "text": "Wipe down hands and surfaces with these gentle soft feeling anti-bacterial wipes. Lightweight and easy to carry, perfect when you are travelling about. Dermatologically tested.\nDettol 2 in 1 Wipes are ideal for on the go. The small packet slips easily into a bag, making this a useful staple for protecting your family from bacteria and viruses. The wipes remove 99.9% of bacteria from hands and surfaces. The wipes are gentle on the skin, and have a mild, fresh scent.\n- Kills 99.9% of bacteria & viruses\n- Dermatologically tested\n- Soft feeling, fresh fragrance\n- For hands and surfaces\nUsage / Instructions\nOpen resealable transparent label and pull in the direction of the arrow to take out a wipe. Close resealable label firmly to prevent remaining wipes drying out. For disinfection, wipe hands thoroughly for 1 minute and let dry for 2 minutes; wipe surfaces completely wet and let dry for 5 minutes.\nPer 100g of product: contains 0.37g Benzalkonium Chloride\nContains < 5% Cationic Surfactants, Disinfectant, Parfum, Benzyl Cinnamate, Citral, Limonene and Linalool", "domain": "chemistry", "round": 3} +{"url": "http://grease-musical.tk/ceran-xm-220-msds-sheets.html", "date": "2019-06-24T09:28:44Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-26/segments/1560627999298.86/warc/CC-MAIN-20190624084256-20190624110256-00379.warc.gz", "language_score": 0.7062432765960693, "token_count": 497, "dump": "CC-MAIN-2019-26", "global_id": "webtext-fineweb__CC-MAIN-2019-26__0__137327400", "lang": "en", "text": "CERAN XM 220 is suitable for the lubrication of continuous sheets castings all industrial applications under severe conditions ( wet, rolling mills in steel msds plants, loaded, dust, high temperature, bearings in wet , dry ( felt rolls) sections of paper mills . Contact Point HSE Number Identified uses E- mail Address rm. Product identifier For the full text of the H- Statements mentioned in this Section, xm sheets see Section 2. Résistance à l’ eau exceptionnelle. Uses advised against msds Do not use for any purpose other than the one for which msds it sheets is intended.\ntotal ceran xm 220 18kg drum. MATERIAL SAFETY DATA SHEET TOTAL Specialties USA, Inc. View the latest Safety ceran Data Sheet. com Lubricating grease. IDENTIFICATION Product xm identifier Product name CERAN XM 460 Other means of identification Product Code( sNumber MWK Substance. Terms & Conditions. Product name CERAN XM 220 Other means of identification Number 4KF Substance/ mixture Mixture Recommended use of the chemical and restrictions on use Identified uses Lubricating grease. SAFETY DATA SHEET According to the Hazard Communication Standard,.\n) CERAN XM 220 is suitable for use ceran in centralized greasing systems. email password login. Ceran xm 220 msds sheets. Shock loaded applications in industry even in severe demanding environment ( water dust high temperature). Details sheets of the xm sheets supplier of msds the sheets safety data sheet. IDENTIFICATION OF ceran THE SUBSTANCE/ MIXTURE AND OF THE COMPANY/ UNDERTAKING REGULATION ( EC) No 1272/ 1.\nSAFETY DATA SHEET according to Regulation ( EC) No. 1907/ _ _ _ _ _ Page 1 / 12 SDS # : 080100 CERAN XM 220 1. IDENTIFICATION OF THE SUBSTANCE/ PREPARATION AND THE COMPANY/ UNDERTAKING 1. Product identifier Product name CERAN XM 220 Number 4KF Pure substance/ mixture Mixture 1. Relevant identified uses of the substance or mixture and uses. CERAN XM 220 Moly has a good pumpability at ambient temperatures.\nceran xm 220 msds sheets\nExcellent thermal stability. It regains its original texture after cooling to ambient temperature.", "domain": "chemistry", "round": 3} +{"url": "https://aurion.nl/products/silver-enhancement-reagents/", "date": "2023-12-07T10:41:45Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100651.34/warc/CC-MAIN-20231207090036-20231207120036-00331.warc.gz", "language_score": 0.8535201549530029, "token_count": 390, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__301933770", "lang": "en", "text": "R-Gent SE-EM Silver Enhancement Reagents\nFor most applications the detection of ultra small gold particles in electron microscopy requires a particle enhancement procedure. Danscher’s method has always been the standard for this purpose and for a long time attempts to improve the features of Danscher’s system met with only limited success.\nThe goal in the development of AURION R-Gent SE-EM was to create a new system with enhancement efficiency and homogeneity at least comparable to Danscher’s method, but with reduced acidity and light sensitivity. In addition, the reagents should have low viscosity for the suitability in pre-embedding immunogold labeling.\nR-Gent SE-LM Silver Enhancement Reagents\nThe Immunogold Silver Staining technique (IGSS) finds application both at the electron microscope and the light microscope level. In addition the technique is used to identify proteins or nucleic acids after blotting.\nLight microscopical and macroscopical visualization of the latent gold signal requires an enhancement system that renders a high contrast signal. Light insensitivity and negligible autonucleation are required for ease of handling and low background. AURION R-Gent SE-LM is a two-component reagent that meets these requirements.\nECS – Enhancement Conditioning Solution\nAurion’s Enhancement Conditioning Solution (ECS) is a concentrate that requires a 10x dilution with distilled grade water before use. It helps optimise enhancement by conditioning specimens labelled with (ultra small) gold conjugates before the silver enhancement procedure using Aurion R-Gent SE-EM. Aurion ECS is a prerequisite to condition enhanced specimens for a second incubation series in double labelling experiments (Yi et al, 2001, Journal of Histochemistry and Cytochemistry 49(3): 279-283).", "domain": "chemistry", "round": 3} +{"url": "https://dr.ntu.edu.sg/handle/10220/48219", "date": "2019-08-21T05:57:19Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-35/segments/1566027315809.69/warc/CC-MAIN-20190821043107-20190821065107-00469.warc.gz", "language_score": 0.8218091130256653, "token_count": 428, "dump": "CC-MAIN-2019-35", "global_id": "webtext-fineweb__CC-MAIN-2019-35__0__194272921", "lang": "en", "text": "Synthesis and optimization of MoS2@Fe3O4-ICG/Pt(IV) nanoflowers for MR/IR/PA bioimaging and combined PTT/PDT/Chemotherapy triggered by 808 nm laser\nDate of Issue2017\nSchool of Physical and Mathematical Sciences\nElaborately designed biocompatible nanoplatforms simultaneously achieving multimodal bioimaging and therapeutic functions are highly desirable for modern biomedical applications. Herein, uniform MoS2 nanoflowers with a broad size range of 80–180 nm have been synthesized through a facile, controllable, and scalable hydrothermal method. The strong absorbance of MoS2 nanoflowers at 808 nm imparts them with high efficiency and stability of photothermal conversion. Then a novel multifunctional composite of MoS2@Fe3O4‐ICG/Pt(IV) (labeled as Mo@Fe‐ICG/Pt) is designed by covalently grafting Fe3O4 nanoparticles with polyethylenimine (PEI) functionalized MoS2, and then loading indocyanine green molecules (ICG, photosensitizers) and platinum (IV) prodrugs (labeled as Pt(IV) prodrugs) on the surface of MoS2@Fe3O4. The resulting Mo@Fe‐ICG/Pt nanocomposites can achieve excellent magnetic resonance/infrared thermal/photoacoustic trimodal biomaging as well as remarkably enhanced antitumor efficacy of combined photothermal therapy, photodynamic therapy, and chemotherapy triggered by a single 808 nm NIR laser, thus leading to an ideal nanoplatform for cancer diagnosis and treatment in future.\n© 2017 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.", "domain": "chemistry", "round": 3} +{"url": "http://www.researchgate.net/publication/21456402_cDNA_cloning_of_human-milk_bile-salt-stimulated_lipase_and_evidence_for_its_identity_to_pancreatic_carboxylic_ester_hydrolase", "date": "2015-07-28T08:59:56Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2015-32/segments/1438042981753.21/warc/CC-MAIN-20150728002301-00263-ip-10-236-191-2.ec2.internal.warc.gz", "language_score": 0.9038220643997192, "token_count": 1336, "dump": "CC-MAIN-2015-32", "global_id": "webtext-fineweb__CC-MAIN-2015-32__0__28829431", "lang": "en", "text": "cDNA cloning of human-milk bile-salt-stimulated lipase and evidence for its identity to pancreatic carboxylic ester hydrolase.\nABSTRACT We have isolated and sequenced cDNA clones covering the entire coding sequence of human-milk bile-salt-stimulated lipase, as well as 996 nucleotides of the 3' end of the pancreatic enzyme carboxylic ester hydrolase. The deduced amino acid sequence of the lipase starts with a 23-residue leader peptide. The open reading frame continues with 722 amino acid residues. The sequence contains in the C-terminal part a proline-rich repeat, 16 repeats of 11 amino acid residues each. The mRNA was estimated to be approximately 2500 nucleotides from Northern blot and of similar size in mammary and pancreatic tissues. Data obtained indicate that the lipase and the carboxylesterase are identical and coded for by the same gene. The cDNA is 2428 bases long, which indicates that a near full-length copy of the transcript has been isolated. Comparisons with other enzymes show that the lipase is a new member of the supergene family of serine hydrolases. It is not only closely related (and in its N-terminal half virtually identical) to lysophospholipase from rat pancreas and cholesterol esterase from bovine pancreas, but also shows a high degree of similarity to several esterases, e.g. acetylcholine esterase. In contrast, no such similarity could be found to typical lipases.\n- SourceAvailable from: Roger Holmes[Show abstract] [Hide abstract]\nABSTRACT: Bile-salt activated carboxylic ester lipase (CEL) is a major triglyceride, cholesterol ester and vitamin ester hydrolytic enzyme contained within pancreatic and lactating mammary gland secretions. Bioinformatic methods were used to predict the amino acid sequences, secondary and tertiary structures and gene locations for CEL genes, and encoded proteins using data from several vertebrate genome projects. A proline-rich and O-glycosylated 11-amino acid C-terminal repeat sequence (VNTR) previously reported for human and other higher primate CEL proteins was also observed for other eutherian mammalian CEL sequences examined. In contrast, opossum CEL contained a single C-terminal copy of this sequence whereas CEL proteins from platypus, chicken, lizard, frog and several fish species lacked the VNTR sequence. Vertebrate CEL genes contained 11 coding exons. Evidence is presented for tandem duplicated CEL genes for the zebrafish genome. Vertebrate CEL protein subunits shared 53-97% sequence identities; demonstrated sequence alignments and identities for key CEL amino acid residues; and conservation of predicted secondary and tertiary structures with those previously reported for human CEL. Phylogenetic analyses demonstrated the relationships and potential evolutionary origins of the vertebrate CEL family of genes which were related to a nematode carboxylesterase (CES) gene and five mammalian CES gene families.Cholesterol 11/2011; 2011:781643. DOI:10.1155/2011/781643\n- [Show abstract] [Hide abstract]\nABSTRACT: Carboxyl ester lipase (CEL) is an enzyme that hydrolyzes a wide variety of lipid substrates, including ceramides, which are known to show inhibitory regulation of pituitary hormone secretion in experimental models. Because no studies on CEL expression in human pituitary and pituitary adenomas have been reported in the literature, we investigated CEL expression in 10 normal pituitary glands and 86 well-characterized pituitary adenomas [12 FSH/LH cell, 17 α-subunit/null cell, 6 TSH cell, 21 ACTH cell, 11 prolactin (PRL) cell, and 19 GH cell adenomas] using IHC, immunoelectron microscopy, Western blotting, and quantitative RT-PCR. In normal adenohypophysis, CEL was localized in GH, ACTH, and TSH cells. In adenomas, it was mainly found in functioning GH, ACTH, and TSH tumors, whereas its expression was poor in the corresponding silent adenomas and was lacking in FSH/LH cell, null cell, and PRL cell adenomas. Ultrastructurally, CEL was localized in secretory granules close to their membranes. This is the first study demonstrating CEL expression in normal human pituitary glands and in functioning GH, ACTH, and TSH adenomas. Considering that CEL hydrolyzes ceramides, inactivating their inhibitory function on pituitary hormone secretion, our findings suggest a possible role of CEL in the regulation of hormone secretion in both normal and adenomatous pituitary cells.Journal of Histochemistry and Cytochemistry 10/2010; 58(10):881-9. DOI:10.1369/jhc.2010.956169 · 2.40 Impact Factor\n- [Show abstract] [Hide abstract]\nABSTRACT: We screened DNAs from 48 Japanese individuals for single-nucleotide polymorphisms (SNPs) in eight cytochrome p450 ( CYP) genes, nine esterase genes, and two other genes by directly sequencing the relevant genomic regions in their entirety except for repetitive elements. This approach identified 607 SNPs and 73 insertion/deletion polymorphisms among the 19 genes examined. Of the 607 SNPs, 284 were identified in CYP genes, 302 in esterase genes, and 21 in the other two genes ( GGT1, and TGM1); overall, 37 SNPs were located in 5' flanking regions, 496 in introns, 55 in exons, and 19 in 3' flanking regions. These variants should contribute to studies designed to investigate possible correlations between genotypes and phenotypes of disease susceptibility or responsiveness to drug therapy.Journal of Human Genetics 02/2003; 48(5):249-70. DOI:10.1007/s10038-003-0021-7 · 2.53 Impact Factor", "domain": "chemistry", "round": 3} +{"url": "http://www.journalejnfs.com/index.php/EJNFS/article/view/26960", "date": "2020-04-02T09:47:19Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-16/segments/1585370506870.41/warc/CC-MAIN-20200402080824-20200402110824-00447.warc.gz", "language_score": 0.950937807559967, "token_count": 403, "dump": "CC-MAIN-2020-16", "global_id": "webtext-fineweb__CC-MAIN-2020-16__0__37567730", "lang": "en", "text": "Main Article Content\nAims: This study was conducted to detect the presence of cyanide in popular fruit and vegetable smoothies and juices marketed as raw and natural.\nStudy Design: Eleven (11) popular varieties of drinks were analyzed for total cyanide (TCN). Drinks contained raw vegetables and fruits, flax seeds, whole apples with seeds, raw almond milk, and pasteurized almond milk as ingredients.\nPlace and Study Duration: Samples were collected from health food eateries located within Las Vegas, Nevada (USA) during the summer of 2017.\nMethodology: Fifty milliliters (mL) of a homogenized smoothie and juice drink and 1 gram of flax seeds were subjected to the above-referenced methods for sample preparation per USEPA Methods 9012B (digestion) followed by USEPA method 9014 (colorimetry).\nResults: The highest TCN was detected in drinks containing raw flax seed followed by unpasteurized raw almond milk, then fresh whole apple juice. No TCN was observed in drinks that contained none of the above mentioned items (e.g. flax seed, raw almond milk) or those utilizing pasteurized ingredients.\nConclusion: This study observed that TCN is present in smoothies and juices containing raw flax seeds, fresh whole apples, and/or unpasteurized almond milk. Concentrations were detected as high as 341 μg L-1 in commercially available smoothies containing vegetables, raw flax seeds, almond milk and fruits. Smoothies with vegetables, fruits, unpasteurized almond milk, and no flax seeds contained 41 ug L-1TCN, while similar smoothies with pasteurized almond milk contained negligible to 9.6 ug L-1 CN-. Unpasteurized almond milk and raw flax seeds were the major sources of TCN in drinks. With the increased demand for raw and natural foods, there is a potential sublethal exposure of TCN by consumers.", "domain": "chemistry", "round": 3} +{"url": "https://iris.univpm.it/handle/11566/73989", "date": "2023-02-06T16:22:47Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-06/segments/1674764500356.92/warc/CC-MAIN-20230206145603-20230206175603-00721.warc.gz", "language_score": 0.8872587084770203, "token_count": 328, "dump": "CC-MAIN-2023-06", "global_id": "webtext-fineweb__CC-MAIN-2023-06__0__140085088", "lang": "en", "text": "The efficacy of cationic peptides combined with betalactams was investigated in a peritonitis rat model. Intraabdominal sepsis was induced in adult Wistar rats via cecal ligation and single puncture. The study included eight drug-treated groups: each of them received intravenous polymyxin-E (1 mg/kg), buforin II (1 mg/kg), imipenem (20 mg/kg), amoxicillin-clavulanate (50 mg/kg), polymyxin-E (1 mg/kg) plus imipenem (20 mg/kg), or amoxicillin-clavulanate (50 mg/kg), and buforin II (1 mg/kg) plus imipenem (20 mg/kg), or amoxicillin-clavulanate (50 mg/kg). The study included an untreated control group that received intravenous isotonic sodium chloride solution. All compounds significantly reduced the lethality and the number of bacteria in abdominal fluid compared with saline treatment. Among compounds, imipenem showed the highest antimicrobial activity, while buforin II produced the highest reduction in plasma endotoxin and TNF-alpha levels. Overall, buforin II and imipenem association were the most effective therapeutic approach. Data presented here suggest the potential advantages of combining antimicrobial agents and compounds able to neutralize the biological effect of the endotoxin.\nFile in questo prodotto:\nNon ci sono file associati a questo prodotto.", "domain": "chemistry", "round": 3} +{"url": "https://reasons.org/explore/publications/articles/vital-poisons", "date": "2023-12-03T06:53:10Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100489.16/warc/CC-MAIN-20231203062445-20231203092445-00482.warc.gz", "language_score": 0.91950523853302, "token_count": 530, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__236113162", "lang": "en", "text": "Perhaps you have noticed the addition of Food and Drug Administration warnings to packages of dietary supplements sold in drug and health food stores. If not, please do. These warning labels subtly announce dramatic new evidence for the divine design of life—and of the earth for sustaining life.\nResearch has identified many dietary essentials, in addition to the familiar one, iron, to be harmful, if not deadly, in certain amounts. Such elements as chromium, molybdenum, selenium, and vanadium, for example, are essential for building proteins, and proteins serve as life’s molecular “factories.” Yet each of these elements is toxic in any but the “just right” amount.\nA finely-tuned balance of such elements in organisms’ external environment also proves necessary but risky. Molybdenum, for instance, though it can be harmful plays a crucial and unique role in “nitrogen fixation,” the process by which nitrogen from the atmosphere attaches to chemicals that can be assimilated by plants. This particular process, without which land life cannot exist, is impossible unless a certain “right amount” of molybdenum resides in the soil.\nFor many years, we have recognized the devastating effects of iron deficiency or iron overabundance in the diet of humans and advanced animals. Year by year, however, the list of lethal yet essential substances grows. Currently that list includes arsenic, boron, chlorine, cobalt, copper, fluorine, iodine, manganese, nickel, phosphorus, potassium, sulfur, tin, and zinc, in addition to the four mentioned above.1\nAt the same time, our astronomy research reveals that the earth’s crust differs significantly from the crusts of other solar system bodies. One difference lies in the relative abundance of various life-essential elements. Earth’s crust contains “just right” quantities of all the elements necessary for the existence and sustenance of advanced land life. This finding can be viewed as a remarkable (more accurately, an impossible) coincidence or as a wondrous indicator of design. To reach for a sound bite, I would say that the gastronomical and astronomical evidences favor purposeful planning and preparation.\n- John Emsley, The Elements , third edition (Oxford, UK: Clarendon Press, 1998), pp. 24, 40, 56, 58, 60, 62, 78, 102, 106, 122, 130, 138, 152, 160, 188, 198, 214, 222, 230.", "domain": "chemistry", "round": 3} +{"url": "https://salvagesecretsblog.com/how-to-reuse-epoxy-resin/", "date": "2023-12-10T22:54:41Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679102697.89/warc/CC-MAIN-20231210221943-20231211011943-00342.warc.gz", "language_score": 0.9273386597633362, "token_count": 1386, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__281483910", "lang": "en", "text": "Reusing your epoxy resin can save you a lot of money. It’s important to know the right way to do it so that it doesn’t have an impact on your project or cause any problems for you in the future.\nIn this blog post, we will show you how to reuse epoxy resin without causing any issues for your project!\nCan You Save Leftover Epoxy\nThe first thing is to make sure your leftover resin is stored in an airtight container before putting it back into storage again.\nThe exterior should be coated with petroleum jelly so there are no gaps or cracks left open where moisture could gather and start seeping through which would ruin the epoxy’s effectiveness when used at a later time.\nOther materials can also be added as long as they are not reactive with the resin itself such as metal shavings but you want to avoid anything combustible because this might cause fire during its next use!\nIf possible, transfer excess amounts of clear-drying epoxy into smaller containers with tight-fitting lids.\nOnce you have put your epoxy resin into storage, make sure to keep it in an area where the temperature is between 50 and 80 degrees Fahrenheit (between 15 – 26 Celsius).\nStoring it at temperatures below this range might cause the curing process of the resin to slow down thus causing it not to harden correctly which may result in a weaker bond or material that has been weakened by exposure to moisture over time.\nAn ideal location would be inside of a plastic bin with desiccant packets for further protection against humidity changes as well as keeping other items like metal shavings separate from your stored epoxies.\nIf possible, let your leftover epoxy cure for about three before returning them back again so you do not damage the shelf life of your epoxy.\nTable of Contents\n- Can You Save Leftover Epoxy\n- Can You Reheat Epoxy Resin\n- How Can You Reuse Resin\n- What Can You Do With Leftover Epoxy\n- How Long Can You Store Epoxy Resin\n- Can You Mix Epoxy Too Much\n- Can I Use A Hairdryer To Dry Resin\n- Can You Pour Epoxy Over Cured Epoxy\n- What Happens If You Overheat Resin\n- Can You Use Leftover Resin\n- Can You Melt And Reuse Resin\nCan You Reheat Epoxy Resin\nEpoxy resin should not be reheated because this can cause it to cure prematurely.\nWhen using epoxy resin, it’s important to measure the amount of hardener you need for your project. If too much is added, curing time may be shortened and if not enough is added, there could be a gap between pieces or incomplete bonding.\nEpoxy resins cure more quickly at higher temperatures so do not leave them in an environment with high heat such as direct sunlight near a heating register.\nThe best way to work with epoxy resin is on a temperature-controlled surface that will keep it at room temperature throughout the application process.\nHow Can You Reuse Resin\nReusing resin is a great way to cut down on plastic waste. If you have large quantities of leftover epoxy resin, it may be time to reuse the material before throwing out any more plastic containers.\nThe next steps will show you how to recycle and reuse your old epoxy resin product for another project or business opportunity!\nWhat Can You Do With Leftover Epoxy\n- Fill holes in wood for a smooth surface.\n- Use it as glue to adhere two items together.\n- Create your own custom epoxy resin art!\nHow Long Can You Store Epoxy Resin\nCan You Mix Epoxy Too Much\nEpoxy resin doesn’t have a pot life like other types of polyurethanes, it sets up in 24 hours.\nThat means that the longer you wait, the harder and more difficult it is to work with your epoxy will become.\nYou can also leave mixed epoxy out for some time without affecting its curing process, but this is counter-productive if you’re trying to use it on a model or project immediately after mixing because the liquid will separate from the hardener over time, leaving a layer of very thin liquid at on top of what was once thick paste.\nIf you need several batches done quickly before setting times kick in, just make sure no parts are sticking together while they cure so they will be easier to separate afterward.\nCan I Use A Hairdryer To Dry Resin\nNo! A hairdryer will cause the resin to bubble up and if you’re not careful, a mess could result.\nCan You Pour Epoxy Over Cured Epoxy\nThe short answer is no. The two-part epoxy will never cross-link and you risk ruining both parts if they mix together, especially since the second part of a two-part resin system begins to set as soon as it’s mixed with the first part.\nIf you accidentally get some on another surface while mixing it yourself, however, don’t worry too much because there are ways to remove cured epoxy.\nWhat Happens If You Overheat Resin\n- It becomes a hard resin.\n- The bubbles start to produce and grow bigger.\nCan You Use Leftover Resin\nYou can use leftover resin. There are many ways to reuse epoxy resin, such as repairing a piece of furniture or filling in holes that have been drilled into surfaces you want to keep smooth.\nHowever, it is important that the surface beneath the old layer has dried completely and there isn’t any loose material on top before applying new layers.\nCan You Melt And Reuse Resin\nIt is possible, but it’s not really recommended. If you choose to do this, be sure to use a double boiler set up so that there is no direct heat on the epoxy container itself.\nMelting the material will lower its viscosity which can cause flow problems in your application area if not done correctly.\nYou also have an increased risk of contamination when reusing materials because they are applied into containers where other projects were completed with potentially harmful residues left behind in them.\nFor these reasons, most people would rather spend another $20-30 dollars buying fresh supplies than take their chances with melted-down resin or curing agent mixed together again!\nCan I Use Plastic Cups For Resin\nPlastic cups are not recommended to use for resin, because they are sometimes made of recycled plastic can be very uneven, and contain air bubbles. If you must use a cup, make sure it is smooth on the interior without any ridges or bumps.", "domain": "chemistry", "round": 3} +{"url": "https://www.aamagnet.com/Technical-Info/", "date": "2022-09-30T20:05:08Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-40/segments/1664030335504.22/warc/CC-MAIN-20220930181143-20220930211143-00102.warc.gz", "language_score": 0.8899047374725342, "token_count": 666, "dump": "CC-MAIN-2022-40", "global_id": "webtext-fineweb__CC-MAIN-2022-40__0__47212713", "lang": "en", "text": "Neodymium Magnet ( also called Neodymium Iron Boron Magnet, Strong Magnet) can be supplied in different grade and size. Basially, N35 grade, N38 grade, N40 grade and N42 grade, these are the most common grade for most applications .\nIf you have no idea about the choice of Neodymium magnet grade, or need technical assistance, please feel free to get in touch with us\nStrong Neodymium Magnet (also called Neodymium Iron Boron Magnet) can be supplied in different dimension\nAnd grade. Many various shape can be made, such as, Block, Ring, Bar, Rod, Disc, Cylinder,\nArc segment, Sphere, Cube, Triangle, Semi-ring, Unique and irregular shapes.\nIf you cannot find what you are looking for here, please contact us.\nNeodymium magnet(also called strong magnet) can be produced in different shapes and sizes. Each shape has\n2 ~4 kinds of magnetization direction, including axially oriented, magnetized through thickness and length,\noriented through diameter, multi-pole oriented on outer surface ,multi-pole oriented on inside diameter, diametrical orientation and so on\nNeodymium magnets have poor resistance to corrosion. In order to protect the neodymium magnet from corrosion, usually, neodymium magnet will be plated.\nThe most common coating for Neodymium magnets is Nickel + Copper + Nickel (Ni + Cu + Ni). This coating offers the magnet relatively good protection from corrosion and passive applications. If the magnet will be exposed to moisture or liquid then consider the use of an organic coating such as Epoxy. A hard wearing coating, Epoxy is suited to applications where the magnet will come under some friction or knocking. Meanwhile, other options for coating are Color Zinc, Zinc, Epoxy resin, Silver, Gold, Tin, and so on.\nNeodymium magnet are widely used in many fields, Industries, Electronic, Automotive,\nEnergy conservation, Telecommunications, Office automation, as well as many other applications.\nNeodymium Magnet ( also known as Neodymium Iron Boron Magnet, Strong Magnet) can be supplied in different grade and size. Basially, N35 grade, N38 grade, N40 grade and N42 grade ,these are the most common grade for most applications.\nIf you have no idea about the choice of Neodymium magnet Grade, or need technical assistance, please feel free to get in touch with us\nResidual Induction( Br): The magnetic induction corresponding to zero magnetizing force in a magnetic material after saturation in a closed circuit; measured in gauss or tesla.\nCoercive Force( Hcb): The value of demagnetizing force that reduces residual induction to zero. Measure of how permanent a magnet is; permanent magnets have a high coercivity. The intensity of a magnetic field needed to demagnetize a substance.The maximum coercive force, as measured on a saturated magnet, is proportional to the remanent flux density. See \"flux density.\" It is expressed in oersteds or kiloAmps per meter (kA/m).", "domain": "chemistry", "round": 3} +{"url": "https://www.jbc.org/article/S0021-9258(21)00655-4/fulltext", "date": "2023-02-04T15:07:59Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-06/segments/1674764500140.36/warc/CC-MAIN-20230204142302-20230204172302-00757.warc.gz", "language_score": 0.9307939410209656, "token_count": 8617, "dump": "CC-MAIN-2023-06", "global_id": "webtext-fineweb__CC-MAIN-2023-06__0__92208074", "lang": "en", "text": "If you don't remember your password, you can reset it by entering your email address and clicking the Reset Password button. You will then receive an email that contains a secure link for resetting your password\nIf the address matches a valid account an email will be sent to __email__ with instructions for resetting your password\nIn the last several years, NAD+ supplementation has emerged as an innovative and safe therapeutic strategy for a wide spectrum of disorders, including diabetes and neuropathy. However, critical questions remain as to how NAD+ and its precursors are taken up by cells, as well as the effects of long-lasting intracellular NAD+ (iNAD+) increases. Here, we investigated the kinetics of iNAD+ levels in different cell types challenged with prolonged exposure to extracellular NAD+ (eNAD+). Surprisingly, we found that after the initial increase, iNAD+ contents decreased back to control levels (iNAD+ resetting). Focusing our attention on HeLa cells, we found that oxygen and ATP consumption occurred with similar temporal kinetics after eNAD+ exposure. Using [3H]NAD+ and [14C]NAD+, we determined that NAD+ resetting was not due to increased dinucleotide extrusion but rather due to reduced uptake of cleaved NAD+ products. Indeed, eNAD+ exposure reduced the expression of the ecto-5′-nucleotidase CD73, the nicotinamide adenine mononucleotide transporter solute carrier family 12 member 8, and the nicotinamide riboside kinase. Interestingly, silencing the NAD+-sensor enzyme sirtuin 1 prevented eNAD+-dependent transcriptional repression of ecto-5′-nucleotidase, solute carrier family 12 member 8, and nicotinamide riboside kinase, as well as iNAD+ resetting. Our findings provide the first evidence for a sirtuin 1–mediated homeostatic response aimed at maintaining physiological iNAD+ levels in conditions of excess eNAD+ availability. These data may be of relevance for therapies designed to support the NAD+ metabolome via extracellular supplementation of the dinucleotide or its precursors.\nIn the last several years, our understanding of the NAD+ metabolome extended from that of a mere electron-carrying cofactor for oxidation–reduction reactions to an essential enzymatic substrate involved in key signaling pathways (\n) such as those brought about by polyADP-ribose polymerases (PARPs), monoADP-ribosyltransferases, sirtuins (SIRTs), and the ADP-ribosyl hydrolase/cyclase (CD38). These enzymes play pivotal roles in DNA repair, gene expression, cell cycle regulation, and calcium signaling (\n). In keeping with the important roles of these functions in disease pathogenesis, a large body of evidence shows that impairment of NAD+ availability, due to either reduced biosynthesis or increased consumption, promotes aging (\n). On this basis, maintenance of intracellular NAD+ (iNAD+) homeostasis may have pleiotropic therapeutic effects. This is well in keeping with experimental evidence that boosting iNAD+ contents with its metabolic precursors such as nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR) is of therapeutic relevance in a wide number of disparate disease models, such as diabetes and neuropathy (\nNicotinamide riboside restores cognition through an upregulation of proliferator-activated receptor-γ coactivator 1α regulated β-secretase 1 degradation and mitochondrial gene expression in Alzheimer’s mouse models.\n). More recently, small-molecule activators of nicotinamide phosphoribosyl transferase (NAMPT), the rate-limiting enzyme of the NAD+ rescue pathway, have been proposed as an additional NAD+ boosting strategy for cytoprotection (\n). On the contrary, pharmacological restriction of iNAD+ availability with specific and potent NAMPT inhibitors may represent an innovative and promising anticancer strategy by impairing the dinucleotide's support to energy metabolism and proliferation (\nDespite the impressive progress made in the field of NAD+ signaling and its involvement in disease pathogenesis, whether/how NAD+ or its precursors are taken up by the different cell types and to what extent this contributes to NAD+ homeostasis is still a matter of debate. Indeed, whereas bacteria (\n) are endowed with specific membrane NAD+ carriers, the plasma membrane NAD+ transporter has yet to be identified. This is in spite of several studies providing evidence that NAD+ crosses the plasma membrane of mammalian cells uncleaved (\nRegardless of the mechanisms underpinning NAD+ uptake, various studies report that the increased availability of eNAD+, both in vitro and in vivo, prompts metabolic and signaling responses that, as a whole, improve bioenergetics and resistance to stress (\n). In this regard, it is worth noting that the temporal kinetics of these perturbations are currently unknown. Indeed, whether cells can prompt compensatory responses aimed at resetting iNAD+ homeostasis once the latter has been altered by increased extracellular availability of the dinucleotide waits to be investigated. This is an essential point in light of the therapeutic potential ascribed to various NAD+ boosting strategies in disorders typically characterized by a chronic pattern of progression that, by definition, would necessitate continuous exposure to NAD+ or its metabolic precursors.\nOn this basis, in the present study, we attempted to understand whether and how iNAD+ homeostasis changes over time in cells challenged with a prolonged increase of eNAD+ availability.\nEffects of prolonged eNAD+ exposure on cellular metabolism\nWe previously reported that iNAD+ contents increase upon a brief exposure of HeLa cells to eNAD+ and that this increase confers significant cytoprotection from apoptosis triggered by staurosporine, C2 ceramide, or N-methyl-N′-nitro-N-nitrosoguanidine (\n). To our knowledge, however, the effects of prolonged exposure of resting cells to eNAD+ have never been investigated. To address this issue, we evaluated the effects of 1 mM eNAD+ on iNAD+ contents in HeLa cells during a 24-h incubation. We found that iNAD+ contents increased from 9.2 ± 1.3 to 19.5 ± 2.4 nmol/mg protein at 8 h and then, surprisingly, linearly decreased over time to return to basal levels after 24 h (Fig. 1A). Notably, the same results were obtained when cells were exposed to lower eNAD+ concentrations (Fig. S1A). Furthermore, to rule out that this finding was specific for HeLa cells, we also evaluated the effects of eNAD+ over time in SHSY-5Y (neuroblastoma), HT29 (colorectal adenocarcinoma), and renal proximal tubule epithelial cells and found similar kinetics of iNAD+ contents upon NAD+ exposure (Fig. 1A). Given that eNAD+ exposure increases both cellular oxygen consumption and ATP content (\n), we next attempted to understand whether these two bioenergetic parameters also showed a biphasic response upon a prolonged challenge to eNAD+. Indeed, the augmented oxygen consumption present in cells exposed to 1 mM NAD+ for 1 h vanished at 24 h, reaching values lower than those of resting cells (Fig. 1, B and C). In keeping with this, we found that ATP contents promptly increased in cells exposed to eNAD+, reaching a maximum at 3 h (from 72 ± 2.3 to 122.4 ± 8.4 nmol/mg protein) and then showed a slow decrease over time reaching the basal level after 30-h incubation (Fig. 1D). Notably, we found that cells exposed to lower eNAD+ concentration presented a lower increase of ATP contents (Fig. S1B) and oxygen consumption (Fig. S1C), which underlies that the changes of these metabolic parameters are linked to changes in NAD contents. We also found a small increase in the ADP pool probably because of a contribution of eNAD+ to the adenylate pool (Fig. S1D). The unexpected return of iNAD+ contents to control levels during eNAD+ exposure hereinafter referred to as “iNAD+ resetting,” prompted us to first hypothesize that it was merely due to its reduction to NADH. We, therefore, measured the cellular contents of NADH over time during eNAD+ exposure and found that they increased by 22.59 ± 3% after 24 h (Fig. 1E). Given that the extent of this increase was not consistent with that of NAD+ resetting (equaling a reduction of 112.28 ± 31% of peak values) (Fig. 1A), we reasoned that mechanisms in addition to NADH formation should be involved. Given that NAMPT and nicotinamide mononucleotide adenylyl transferases (NMNATs) play a key role in the maintenance of iNAD+, we hypothesized that changes in their expression levels could contribute to NAD+ resetting. We found, however, that transcript levels for NAMPT, NMNAT1, and NMNAT3 did not change and those for NMNAT2 almost doubled, whereas those of nicotinamide riboside kinase (NRK1) decreased by 9-fold in cells exposed to eNAD+ for 24 h (Fig. 1F).\nProlonged eNAD+ exposure reduces eNAD+ uptake\nIn an attempt to identify additional mechanisms underlying iNAD+ resetting, we hypothesized involvement of the NAD+-consuming enzymes PARPs or/and mono (ADP-ribose) polymerases. We found, however, that a high concentration of two different PARP inhibitors PJ34 (10 μM) (\n), did not affect the kinetic of NAD+ resetting (data not shown). Next, to rule out the possibility that iNAD resetting might be due to eNAD depletion over time, we analyzed the NAD contents after 24 h in the medium. We found a progressive NAD depletion over time in the medium; however, eNAD contents did not reach control levels after 24-h incubation (Fig. 2A). Moreover, we performed a new experiment adopting 10 instead of 1 mM eNAD+ and found that a similar iNAD resetting occurred despite a lack of eNAD depletion over time, ruling out that iNAD+ resetting is related to eNAD depletion (Fig. 2, A and B). As an alternative hypothesis, we investigated whether NAD+ resetting might be due to extracellular extrusion of the dinucleotide. To this end, we measured the extent of radioactivity extrusion by cells preloaded for 1 h with adenine-labeled [3H]NAD+ (Fig. 2C) and then exposed or not to unlabeled eNAD+ for 24 h (Fig. 2D). Interestingly, we found increased radioactivity in the medium of eNAD+-exposed cells (Fig. 2E), thereby suggesting that extrusion indeed contributes to NAD+ resetting. Still, to make sure that the dinucleotide is extruded intact, we repeated the experiment with NAM-labeled [14C]NAD+ (Fig. 2C). Surprisingly, we found exactly the opposite result, that is, a decreased amount of radioactivity extruded in the medium of eNAD+-exposed cells (Fig. 2E). These findings on the one hand indicated that NAD+ resetting is not due to a mere extrusion of NAD+ and on the other hand that radioactivity observed in the medium is related to NAD+-cleaved products.\nWe next moved on to check whether reduced eNAD+ uptake contributes to NAD+ resetting. We, therefore, evaluated whether the uptake of radioactivity originating from [3H]NAD+ or [14C]NAD+ differed in cells exposed or not to eNAD+. Interestingly, we found that the uptake of the radioactivity of both labeled NAD+ moieties was lower in cells exposed to eNAD+ for 24 h and returned to control levels upon 24 h eNAD+ washing (Fig. 3, A and B). The fact that radioactivity was measured in cells that already reset NAD+ content rules out that the reduced uptake might be due to high intracellular dinucleotide levels. These findings, therefore, suggested that mechanisms responsible for NAD+ uptake are altered upon prolonged eNAD+ exposure. As mentioned above, experimental evidence indicates that NAD+ is taken up by the plasma membrane both intact (\n). We, therefore, analyzed the transcript levels of both ectoenzymes in cells challenged with a 12- or 24-h exposure to eNAD+ and found a significant reduction of mRNAs of CD73 after 24 h and no effect on those of CD38 and CD157, whereas CD203a transcript levels were not detectable (Fig. 3C). To confirm that reduction of CD73 transcripts was functionally relevant, we measured intracellular adenosine (ADO) contents upon extracellular [14C]AMP exposure as a prototypical indirect index of CD73 activity (\n). In keeping with the PCR data, we found that the increase of intracellular radioactivity was lower in eNAD+-exposed cells than the controls (Fig. 3D). Notably, a complete restoration of CD73 transcript levels occurred upon eNAD+ washing (Fig. 3C). We also evaluated the effect of eNAD+ on transcript levels of SARM1, an important NADase that could play a role in NAD degradation (\n). We found that eNAD+ exposure did not alter mRNA levels of SARM1 over time (Fig. 3C). Conversely, we found that transcript levels of the NMN transporter Slc12a8 were already reduced in cells after 12-h eNAD+ exposure and similar to those of CD73 recovered upon washing (Fig. 3C). In light of the putative role of plasma membrane equilibrative nucleoside transporters (ENTs) in eNAD+ uptake (\n), we also evaluated whether eNAD+ exposure changed mRNA levels of ENT1 and ENT2. We found that eNAD+ prompted substantial increases of ENT1 mRNAs, having no effects on those of ENT2 (Fig. 3C). We also investigated whether gene expression changes observed in eNAD+-treated cells also occurred in cells exposed to NAD-cleaved products. Interestingly, we found that among NRK1, CD73, ENT1, and Slc12a8, only the expression of the latter is reduced by 24-h NMN or ADO exposure, whereas NR had no effects on analyzed genes (Fig. S1E).\nIn light of the role of CD73 and Slc12a8 in the uptake of NAD+-cleaved products, our findings suggested that the reduced expression of both proteins could contribute to iNAD+ resetting. To corroborate this hypothesis, we again took advantage of [3H]-adenine–labeled and [14C]-NAM–labeled NAD+ and checked whether radioactivity uptake changed in the presence of unlabeled eNAD+ or its presumed cleaved products. We found that NAD+ and ADO reduced the uptake of radioactivity originating from [3H]NAD+ (Fig. 3E), whereas NAD+, NMN, and NR reduced the uptake of radioactivity originating from [14C]NAD+ (Fig. 3F). Notably, silencing of NMN transporter Slc12a8 reduced the uptake of radioactivity when NAM-labeled [14C]NAD+ was added extracellularly (Fig. 3, G and H), indicating a contribution of this transporter on uptake of NAD+. To evaluate the contribution of serum enzymes involved in eNAD+ hydrolysis (\n), we performed experiments studying the uptake of radioactivity from labeled NAD+ moieties without serum. As shown in Figure S2, A and B, we found that radioactivity uptake is not affected by the absence of serum.\nThese findings suggest that, at least in part, eNAD+ is cleaved extracellularly and the degradation products are taken up by the plasma membrane through different routes in keeping with prior work (\n) on eNAD+ uptake. We found that AMPCP was able to reduce the uptake of radioactivity when both [3H]NAD+ and [14C]NAD+ were added extracellularly (Fig. 3I), thereby confirming the key role of eNAD+ hydrolysis by the ectoenzyme for subsequent uptake of degradation products. It is worth noting that we used AMPCP at a concentration capable of reducing the uptake of radioactivity originating from [14C]AMP by 94 ± 3% (Fig. 3I). Given that this radioactivity is related to the uptake of [14C]adenosine formed extracellularly by CD73 (\n), the latter finding suggested that under our experimental setting AMPCP prompted an almost complete inhibition of the ectoenzyme. On this basis, we reasoned that the cellular radioactivity accumulating in cells exposed to labeled NAD+ in the presence of AMPCP (Fig. 3I) is CD73 independent. Accordingly, we found that prolonged exposure to AMPCP affected the increase of iNAD+ in the early time points when cells were exposed to unlabeled eNAD+ (Fig. S2C). We then evaluated the CD73-independent metabolism of eNAD+ via the NAM-forming CD38. We found that the addition of a molar excess of extracellular NAM, used as a product inhibitor of CD38, did not alter radioactivity uptake when cells were exposed either to [3H]NAD+ or to [14C]NAD+ (Fig. 3J). In keeping with this, the CD38 inhibitor apigenin (\n) did not reduce the uptake of radioactivity originating from [14C]NAD+ (Fig. 3K). Hence, the CD73-independent uptake of radioactivity in cells exposed to labeled NAD+ might be ascribed to intact NAD+ transportation. Accordingly, we found that NAMPT or NRK1 silencing did not prevent iNAD+ increase after eNAD+ exposure (Fig. S2, D and E), supporting the hypothesis that, at least in part, NAD+ was transported intact.\nCollectively, these findings indicate that increased iNAD+ content due to prolonged eNAD+ exposure triggers a complex cascade of transcriptional events involving plasma membrane eNAD+-metabolizing enzymes and transporters aimed at reestablishing NAD+ homeostasis.\nSIRT1 activity prompts iNAD+ resetting\nTo further understand the molecular mechanisms underlying iNAD+ resetting, we focused our attention on SIRTs. The latter are NAD+-dependent deacetylases with a key transcription-regulating function (\n). We hypothesized that changes in SIRT1 activity due to increased substrate availability concur to regulate the expression of enzymes/carriers involved in iNAD+ resetting. To verify this hypothesis, we suppressed SIRT1 expression approximately by 90% by means of siRNA (Fig. 4A). Next, we set up a silencing protocol in which cells were exposed or not to siRNA for 48 h and to eNAD+ for the last 24 h. Remarkably, as shown in Figure 4B, the increase in iNAD+ at 8 h was significantly higher in SIRT1-silenced cells than that occurring in cells proficient for SIRT1. More importantly, silencing of SIRT1 abrogated NAD+ resetting (Fig. 4B). To rule out that silencing SIRT1 could increase basal iNAD+ contents and the latter might be at least in part responsible for preventing iNAD+ resetting, we measured iNAD+ contents under basal conditions (i.e., without eNAD+ exposure) in resting and SIRT1-silenced cells. As shown in Figure 4C, SIRT1 silencing did not affect iNAD+ content in basal condition. In keeping with a key role of CD73 and Slc12a8 transcriptional suppression in iNAD+ resetting, silencing of SIRT1 prevented downregulation of both transcripts in eNAD+-exposed cells (Fig. 4D). SIRT1 silencing also sufficed to prompt CD73 and Slc12a8 mRNA increases in control cells (Fig. 4D), consistent with SIRT1-dependent constitutive suppression of CD73 and Slc12a8 transcription. Similarly, also NRK1 transcriptional suppression induced by prolonged eNAD+ exposure (Fig. 1F) was reverted by SIRT1 silencing, and, again, its basal transcript levels increased in SIRT1-silenced cells (Fig. 4D). Notably, we found that genes that did not affect during eNAD+ exposure (NAMPT, NMNAT1, NMNAT3, ENT2, CD38) were not regulated by SIRT1 silencing, contrarily NMNAT2 and ENT1, whose levels were changed by NAD+ exposure, were affected by SIRT1 silencing (Fig. 4E). Collectively, these data on the one hand highlight the role of SIRT1 in regulating the expression of genes involved in eNAD+ metabolism and uptake and on the other hand to its transcriptional regulating ability as a central mechanism of NAD+ resetting. To corroborate this assumption, we conducted an in silico analysis of the transcription factors (TFs) known to bind the promoters of the various genes we evaluated in cells exposed to eNAD+. Specifically, we divided the genes into two groups, that is, those whose expression is affected during NAD+ resetting (CD73, Slc12a8, ENT1, NRK1, NMNAT2) and those that do not undergo transcriptional changes (NAMPT, NMNAT1, NMNAT3, ENT2, CD38). Using the Ciiider software (\n) (developed to identify TF DNA-binding elements) and the database Biological General Repository for Interaction Datasets (www.thebiogrid.org, a repository for protein–protein interaction), for each gene, we then evaluated the number of TFs binding to the corresponding promoter and known to interact with SIRT1. Interestingly, as shown in Figure 4F, the number of SIRT1-regulated TFs was 15 for genes whose expression changed during NAD+ resetting and seven for those showing no transcriptional changes. The higher number of SIRT1-regulated TFs binding to promoters of genes altered during eNAD+ exposure supports the hypothesis that SIRT1 contributes to the transcriptional changes during iNAD+ resetting.\nIn light of the consolidated role of iNAD+ availability in counteracting pathogenesis of numerous disorders, extracellular supply of the dinucleotide and its precursors received great attention as a safe and innovative therapeutic strategy. In this scenario, the present study demonstrates that cells bring about a SIRT1-dependent homeostatic response aimed at restoring physiological iNAD+ contents. SIRT1 being a key sensor of iNAD+ content and transcriptional regulator makes sense that the enzyme is centrally poised to regulate the NAD+ resetting response.\nA key finding of our study is that upon eNAD+ exposure, cells undergo transient iNAD+ increase followed by an exact resetting to control levels. Of note, this occurs despite the continuous presence of high extracellular dinucleotide concentrations. Intrigued by the underlying molecular mechanism, we set up experiments to understand whether resetting was due to NAD+ consumption and/or extrusion. As far as consumption is concerned, according to the literature (\n), PARP-1 is the sole enzyme that can prompt an extent of NAD+ consumption consistent with the quantitative aspect of NAD+ resetting (i.e., an amount of NAD+ corresponding to almost 100% of its basal content, see Fig. 1A). However, two potent PARP inhibitors proved unable to affect NAD+ resetting, in keeping with the apparent lack of triggers prompting PARP-1 activation in cells with increased iNAD+ contents. Our findings also rule out the possibility that NAD+ resetting is due to dinucleotide extrusion. Indeed, although cells loaded with [3H]NAD+ increase extrusion of radioactivity upon eNAD+ exposure, the opposite occurs in those loaded with [14C]NAD+. This is not consistent with the extrusion hypothesis as the mechanisms are responsible for NAD+ resetting. Rather, these findings, together with evidence of induction of the ENT1 in eNAD+-exposed cells (Fig. 3C), indicate that a reduction in intracellular ADO compromises the adenylate pool for the resynthesis of NAD+. Although this mechanism may well underlie iNAD+ resetting, the additional finding that ATP contents are increased rather than reduced during iNAD+ resetting rules out this hypothesis. Also, the increased availability of ATP in eNAD+-exposed cells suggests that iNAD+ resetting cannot be ascribed to a reduced dinucleotide resynthesis through the ATP-dependent NAMPT and NMNATs.\nThe reduction in uptake of radioactivity originating both from [3H]NAD+ and [14C]NAD+ when cells are pre-exposed to eNAD+ suggests that reduced eNAD+ uptake contributes to iNAD+ resetting. Specifically, data indicate that, at least in part, resetting is due to diminished eNAD+ hydrolysis and ensuing uptake of related products. In this regard, prior works report the hydrolysis of eNAD+ by CD73 (\n). Our data are in keeping with this claim by showing that while extracellular ADO affects the uptake of the radioactivity of [3H]-adenine-labeled NAD+, NR and NMN reduce that of [14C]-NAM–labeled NAD+. Taken together, these findings suggest that eNAD+ is cleaved extracellularly into adenine- and NAM-containing moieties that are taken up by at least two different routes, such as ENTs and Slc12a8, respectively. Of note, the inability of NR to reduce the uptake of radioactivity originating from [3H]NAD+ (that is [3H]adenosine) (Fig. 3D) also suggests that, at least under our experimental conditions, NR does not compete with ADO to cross the plasma membrane via ENTs. Conversely, the ability of the CD73 inhibitor AMPCP to reduce the uptake of radioactivity originating from both [3H]NAD+ and [14C]NAD+ indicates the key functional role of CD73 in eNAD+ hydrolysis and subsequent increase of iNAD+. In this regard, the reduced CD73 expression levels, as well as its activity in cells challenged with eNAD+, points to these transcriptional repressions as a central event in NAD+ resetting. Evidence that, akin to CD73, the expression of both Slc12a8 (a specific NMN transporter (\n)) diminishes upon eNAD+ exposure provides additional mechanisms underpinning iNAD+ resetting. Of note, we report that Slc12a8 silencing reduced [14C]-NAM–labeled NAD+ uptake, confirming the role of this transporter in NAD+ uptake and its contribution to restoring NAD+ contents to control levels. Admittedly, additional molecular mechanisms might concur to reestablishing iNAD+ content upon prolonged eNAD+ exposure. We provide here, however, the first evidence that, among these mechanisms, SIRT1 is a key player of the iNAD+ resetting response. In particular, our data suggest that the increased availability of iNAD+ in eNAD+-exposed cells promotes SIRT1 activity that, in turn, prompts CD73, Slc12a8, and NRK1 transcriptional repression. This compromises the efficiency of the molecular machinery responsible for eNAD+-induced iNAD+ increase, thereby contributing to iNAD+ resetting. The key role of SIRT1 in iNAD+ resetting is well in keeping with the ability of the enzyme to adjust its activity according to the intracellular availability of NAD+, as well as with its epigenetic functions (\n). This interpretation is also in line with our in silico analysis showing that those genes whose expression changes during iNAD+ resetting have some SIRT1-interacting TFs double that of genes not affected by eNAD+ exposure. It is also worth noting that silencing of SIRT1 suffices to prompt a 4-fold increase of CD73 and Slc12a8 transcripts in resting cells, thereby indicating a constitutive role of the enzyme in repressing transcription of these genes. Of note, we found that SIRT1 silencing prompts transcriptional changes only toward genes that are affected by eNAD+ exposure, thereby underlying the correlation between NAD+ contents and transcriptional regulation by SIRT1.\nRegardless of the role of CD73 and Slc12a8 in eNAD+ uptake, our data also suggest that eNAD+ can cross the plasma membrane uncleaved. Indeed, in the presence of an extracellular concentration of AMPCP leading to an almost complete CD73 inhibition (see Fig. 2H), eNAD+ can still prompt significant iNAD+ increases. Furthermore, silencing of NAMPT or NRK1 did not reduce the iNAD+ increase under eNAD exposure, suggesting that part of NAD+ was not cleaved. This is in keeping with prior findings on the ability of eNAD+ to trigger iNAD+ increases without evidence for extracellular hydrolysis (\n). Admittedly, even if our assumption is supported by prior and present experimental evidence, it is not consistent with the ability of SIRT1 silencing to prevent iNAD+ resetting by reducing CD73 and Slc12a8 NMN transporter. This apparent inconsistency might be reconciled if even the expression of the yet to be identified plasma membrane NAD+ transporter was negatively regulated by SIRT1. However, only NAD+ transporter identification will confirm this hypothesis.\nOur study presents some limitations. First, we report total iNAD+ concentration, without specifying in which compartment NAD+ increase occurred; this limit may be the subject of future studies. Second, because under physiological conditions, in mammalian serum, NAD+ circulates in the low micromolar range (0.1–0.5 μM), NAD+ concentrations used in our study are doubtless high. However, our findings lay the basis for a finely tuned signaling pathway able to sense derangements of NAD+ homeostasis and prompt resetting of physiological conditions. Third, we emphasize that even if our findings provide evidence for unprecedented molecular machinery responsible for resetting cellular NAD+ content upon an initial increase, they do not clarify how iNAD+ decreases during NAD+ resetting and reaches exactly the original control values. Indeed, the SIRT1-activated feedback mechanism impinging on CD73, Slc12a8, and NRK1 expression, in principle, should only counteract further iNAD+ increases, somehow freezing the cell in a cytoplasmic milieu containing an increased NAD+ content. In other words, mechanisms responsible for reducing iNAD+ to the initial basal levels, once the entrance apparatus has been impaired, are still unknown.\nFrom a theoretical point of view, in light of the pleiotropic and critical functions of NAD+ signaling (DNA repair, transcription, Ca2+ homeostasis, energetic metabolism, mitochondrial dynamics, etc.), it makes sense that evolution provided eukaryotic cells with feedback molecular machinery aimed at counteracting derangements of NAD+ availability that might severely compromise cellular homeostasis. Given the great interest in the NAD+ boosting approach, evaluating this regulatory mechanism could prevent saturation phenomena in vivo and help identify the therapeutic dosing regimen.\nIn conclusion, the present study furthers our understanding of the complex network of events that regulate iNAD+ content. Finally, it suggests that the therapeutic potential of the different NAD+-boosting strategies (\n) might be significantly reduced in those tissues in which the NAD+-resetting response is functionally relevant. Of course, NAD+-supplementation strategies may still be of therapeutic relevance in conditions of iNAD+ deficiency.\nHeLa, primary renal proximal tubule epithelial, SH-SY5Y, and HT29 human cells were obtained from American Type Culture Collection. Cells were grown in Dulbecco's modified Eagle's medium (DMEM) containing 25 mM glucose and supplemented with 2 mM glutamine, 1 mM pyruvate, 10% fetal bovine serum, and antibiotics. Cultures were brought to 50 to 70% confluence and exposed to different compounds. NAM dinucleotide (NAD+), NMN, NAM, and ADO were purchased by Sigma-Aldrich. NR was synthesized as described by Yang et al. (\n). NAD+, NMN, NR, NAM, and ADO were dissolved in culture media. Apigenin was dissolved in DMSO (Sigma-Aldrich). PJ34, 6(5H)-phenanthridinone, AMPCP, and novobiocin were dissolved in water (Sigma-Aldrich). All results are expressed as the percentage of the control (untreated cells); each sample was normalized by the protein content.\nNAD+, NADH, ADP, and ATP measurement\nNAD+ and NADH contents were quantified through an enzymatic cycling procedure as reported (\n). Briefly, to measure NAD+ contents, cells grown in a 48-well plate were killed with 1 M 50 μl of HClO4 and then neutralized with an equal volume of 1 N KOH. After the addition of 100 μl of bicine (100 mM), 100 μl of the cell extract was mixed with an equal volume of the bicine buffer containing ethanol, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium, phenazine ethosulfate, and alcohol dehydrogenase. The mixture was kept at room temperature for 10 min, and then, absorbance at 550 nm was measured (VICTOR3, PerkinElmer). To measure intracellular NADH contents, cells grown in a 24-well plate were killed with 1 N 80 μl of KOH and then heated to 60 °C for 30 min. After the addiction of 500 μl of bicine (100 mM), 100 μl of the cell extract was mixed with an equal volume of the bicine buffer containing ethanol, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium, phenazine ethosulfate, and alcohol dehydrogenase and measured as described above. ADP contents were quantified in 0.25 N HCl cell extracts (from 6-well plate) by HPLC using a Supelco 25-cm column (5 μm), mobile phase K2HPO4 0.1 M, 1% acetonitrile, 10 mM tetrabutylammonium bromide, pH 6.9, and UV detection at 260 nm (\n). Cellular ATP content was measured using an ATPlite kit (PerkinElmer, Milan). Briefly, cells grown in a 48-well plate were killed with 70 μl of luciferase buffer and then 20 μl of D-luciferin was added. The production of light caused by the reaction of ATP with added luciferase and D-luciferin was evaluated within 5 min by means of a luminometer.\nOxygen consumption analysis\nQuantitation of oxygen consumption was conducted by means of the Oxygraph system (Hansatech Instruments) as reported (\n). Cells (250,000), exposed or not to NAD+ 1 mM or 100 μM, at different times, were gently detached with trypsin and loaded in the chamber containing 300 μl of DMEM. Oxygen consumption was monitored for 5 min at 37 °C.\nNAD+ and AMP uptake measurement\nCells plated in 12 wells plates were grown to confluence. When cells were preincubated with 1 mM unlabeled NAD+ for 24 h, the wells were washed three times with 1 ml of PBS and then incubated in a buffer solution (140 mM NaCl, 10 mM Hepes/Na, 2.5 mM MgSO4, 2 mM CaCl2, and 5 mM KCl, 5 mM glucose, pH 7.4) containing 500 pM [14C]NAD+ (54 mCi/mmol), [3H]NAD+ (28.6 Ci/mmol), or [14C]AMP (60 mCi/mmol) (PerkinElmer). Competing compounds and drugs were added to the wells 15 min before labeled molecules unless stated in the text. After 10 min, cells were washed three times with 1 ml of PBS and lysed with 0.5 M NaOH. Incorporated radioactivity was assayed by liquid scintillation counting.\nRNA isolation and qPCR\nTotal RNA was isolated using TRIzol Reagent (Life Technologies). One microgram of RNA was retrotranscribed using iScript (Bio-Rad). Real-time PCR was performed using Rotor-Gene 3000 (Qiagen) as reported (\nNine thousand cells were subcultured in 48-well plates and then incubated with 50 nM SIRT1, NAMPT, NRK1, or Slc12a8 siRNA. After 24 h, cells were exposed or not at 1 mM NAD+, and after 24 h, the NAD+ content was measured or RNA was extracted. The following primers were used: SIRT1 5′-CAAAGGAUAAUUCAGUGUCAUGGTT and 5′-AGGUUUCCUAUUAAGUCACAGUACAA; NRK1 5′-GCAGUCACAAUGAAUAAA and 5′-UUGUUGAUUUAUUCAUUG; Slc12a8 5′-CUUCUCAUCAUGUUUGUG and 5′-ACUGUAUCACAAACAUGA (IDT, Tema Ricerca). siRNA for NAMPT was purchased from Qiagen.\nAnalysis of TF-binding sites in the promoter region of selected genes was conducted by using CiiiDER software (cit. CiiiDER: a tool for predicting and analyzing TF-binding sites). The analysis was performed using the human motifs from the Jaspar 2020 core redundant vertebrate TF-binding site database (http://jaspar.genereg.net/tools). Subsequently, TFs were selected based on their interaction with SIRT1, identified by means of Biological General Repository for Interaction Datasets database.\nData are presented as the mean values ± SD. All differences among groups were performed using ANOVA followed by Tukey's W-test. Levels of significance were p < 0.05 (∗), p < 0.01 (∗∗), and p < 0.001 (∗∗∗). Statistical analyses were carried out using GraphPad Prism (version 7).\nAll data described in the article are contained within the article.\nThe authors declare that they have no conflicts of interest with the contents of this article.\nD. B. data curation; D. B. and A. C. supervision; D. B., G. R., M. P., A. C., and A. L. investigation; D. B. and A. C. writing-original draft; G. R. validation; A. C., D. B., M. P., A. L., and S. B. methodology; S. B. software; A. C. funding acquisition.\nFunding and additional information\nThis work was supported by Grant AIRC and Fondazione CR Firenze under IG 2017 - ID. 20451 project (Principal Investigator, A. C.).\nNicotinamide riboside restores cognition through an upregulation of proliferator-activated receptor-γ coactivator 1α regulated β-secretase 1 degradation and mitochondrial gene expression in Alzheimer’s mouse models.", "domain": "chemistry", "round": 3} +{"url": "https://iris.unipv.it/handle/11571/1472174", "date": "2023-11-30T05:37:49Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100164.87/warc/CC-MAIN-20231130031610-20231130061610-00394.warc.gz", "language_score": 0.932675838470459, "token_count": 460, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__235513332", "lang": "en", "text": "Bladder cancer is the 10th most common cancer in the world and has a high risk of recurrence and metastasis. In order to sustain high energetic needs, cancer cells undergo complex metabolic adaptations, such as a switch toward aerobic glycolysis, that can be exploited therapeutically. Reactive oxygen species (ROS) act as key regulators of cancer metabolic reprogramming and tumorigenesis, but the sources of ROS remain unidentified. Monoamine oxidases (MAOs) are mitochondrial enzymes that generate H2O2 during the breakdown of catecholamines and serotonin. These enzymes are particularly important in neurological disorders, but recently, a new link between MAOs and cancer has been uncovered, involving their production of ROS. At present, the putative role of MAOs in bladder cancer has never been evaluated. We observed that human urothelial tumor explants and the bladder cancer cell line AY27 expressed both MAO-A and MAO-B isoforms. Selective inhibition of MAO-A or MAO-B limited mitochondrial ROS accumulation, cell cycle progression and proliferation of bladder cancer cells, while only MAO-A inhibition prevented cell motility. To test whether ROS contributed to MAO-induced tumorigenesis, we used a mutated form of MAO-A which was unable to produce H2O2. Adenoviral transduction of the WT MAO-A stimulated the proliferation and migration of AY27 cells while the Lys305Met MAO-A mutant was inactive. This was consistent with the fact that the antioxidant Trolox strongly impaired proliferation and cell cycle progression. Most interestingly, AY27 cells were highly dependent on glucose metabolism to sustain their growth, and MAO inhibitors potently reduced glycolysis and oxidative phosphorylation, due to pyruvate depletion. Accordingly, MAO inhibitors decreased the expression of proteins involved in glucose transport (GLUT1) and transformation (HK2). In conclusion, urothelial cancer cells are characterized by a metabolic shift toward glucose-dependent metabolism, which is important for cell growth and is under the regulation of MAO-dependent oxidative stress.\nFile in questo prodotto:\nNon ci sono file associati a questo prodotto.", "domain": "chemistry", "round": 3} +{"url": "https://standards.globalspec.com/std/435963/astm-c128", "date": "2020-12-01T20:44:55Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-50/segments/1606141681524.75/warc/CC-MAIN-20201201200611-20201201230611-00489.warc.gz", "language_score": 0.8769668936729431, "token_count": 251, "dump": "CC-MAIN-2020-50", "global_id": "webtext-fineweb__CC-MAIN-2020-50__0__171988193", "lang": "en", "text": "Standard Test Method for Specific Gravity and Absorption of Fine Aggregate\n|Publication Date:||10 November 1997|\n|ICS Code (Concrete and concrete products):||91.100.30|\n1.1 This test method covers the determination of bulk and apparent specific gravity, 23/23°C (73.4/73.4°F), and absorption of fine aggregate.\n1.2 This test method determines (after 24 h in water) the bulk specific gravity and the apparent specific gravity as defined in Terminology E 12, the bulk specific gravity on the basis of weight of saturated surface-dry aggregate, and the absorption as defined in Definitions C 125.\nNOTE 1--The subcommittee is considering revising Test Methods C 127 and C 128 to use the term \"density\" instead of \"specific gravity\" for coarse and fine aggregate, respectively.\n1.3 The values stated in SI units are to be regarded as the standard.\n1.4 This standard does not purport to address all of the safety concerns, if any, associated with its use. It is the responsibility of the user of this standard to establish appropriate safety and health practices and determine the applicability of regulatory limitations prior to use.", "domain": "chemistry", "round": 3} +{"url": "http://www.healthdisparitiesks.org/2016/11/30/in-addition-to-being-nutrients-free-fatty-acids-act-as-signaling/", "date": "2024-04-25T01:37:45Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712296820065.92/warc/CC-MAIN-20240425000826-20240425030826-00767.warc.gz", "language_score": 0.9363820552825928, "token_count": 1227, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__7289491", "lang": "en", "text": "In addition to being nutrients free fatty acids act as signaling molecules by activating a family of G protein-coupled receptors. to fully abrogate conversation with arrestin-3 but further mutagenesis of negatively charged residues revealed additional structural components for the conversation with arrestin-3 within the C-terminal tail of the receptor. These elements consist of the acidic residues Glu341 Asp348 and Asp355 located close to the phosphorylation sites. Receptor phosphorylation thus operates in concert with structural elements within the C-terminal tail of FFA4 to allow for the recruitment of arrestin-3. Importantly these mechanisms of arrestin-3 recruitment operate separately from Gq/11 coupling thus offering the chance that ligands displaying stimulus bias could possibly be created that exploit these differential coupling systems. Furthermore Triptophenolide this gives a technique for the look of biased receptors to probe physiologically relevant signaling. luciferase (Rluc) had been as referred to previously (15). To create a C-terminal HA epitope-tagged type of FFA4 the receptor coding series was amplified by PCR using the forwards (5′-TTTTAAGCTTGCCACCATGTCCCCTGAATGCGC-3′) and invert (5′-TTTTGGATCCTTAAGCGTAATCTGGAACATCGTATGGGTAGCCAGAAATAATCGACAAGTCA-3′) primers which included the HA label series followed by an end codon rigtht after the ultimate codon of FFA4. This PCR product was inserted in to the HindIII and BamHI sites of pcDNA5 FRT/TO then. To create FFA4 truncations the FLAG-FFA4 series was amplified through the FLAG-FFA4-eYFP plasmid using the forwards primer 5′-TGCTAAGCTTCTTGCCACCATGGACTA-3′ coupled with a invert primer for every truncation the following: 336 5 340 5 345 5 350 5 and 355 5 Each PCR item was then placed in to the pcDNA5 FRT/TO vector instantly prior to the coding series for eYFP. Mutations towards the FFA4 series had been included using the QuikChange technique (Stratagene Cheshire UK) as well as the identities of most plasmids generated had been verified through sequencing. Steady Cell Lines Steady inducible Flp-InTM T-RExTM cells had been produced by co-transfecting FLAG-FFA4-eYFP FLAG-FFA4-TSS/AAA-eYFP or FLAG-FFA4-340-eYFP using the pOG44 plasmid into parental Flp-In T-REx cells (Lifestyle Technologies). Pursuing transfection hygromycin B was put into the culture moderate enabling polyclonal collection of steady cell lines that inducibly portrayed the receptor appealing in response towards the antibiotic doxycycline. Chinese language hamster ovary (CHO) cells that stably and constitutively portrayed the C-terminal HA epitope-tagged FFA4 or FFA4 formulated with mutations inside the C-terminal tail had been produced using the Flp-In program. CHO Flp-In cells had been co-transfected with pcDNA5FRT formulated with FFA4 and pOG44 transfected cells had been chosen with hygromycin B and appearance of FFA4 was verified by immunoblotting with anti-HA antibodies. [32P]Orthophosphate Labeling and FFA4 Immunoprecipitation Cells had been plated in 6-well plates at 200 0 cells/well 24 h before Mouse monoclonal to IL-6 experimentation. For phosphorylation tests cells had Triptophenolide been washed 3 x with Krebs/HEPES buffer without phosphate (118 mm NaCl 1.3 mm CaCl2 4.3 mm KCl 1.17 MgSO4 Triptophenolide 4.17 mm NaHCO3 11.7 mm blood sugar 10 mm HEPES (pH 7.4)) and incubated within this buffer containing 100 μCi/ml [32P]orthophosphate for 1 h in 37 °C. Cells had been activated for 5 min with check compounds and instantly lysed by addition of buffer formulated with 20 mm Tris (pH 7.4) 150 mm NaCl 3 mm EDTA 1 Nonidet P-40 0.5% sodium deoxycholate. FFA4 was immunoprecipitated through the cleared lysates using anti-HA affinity matrix (Roche Applied Research). The cleaned immunoprecipitates had been separated by SDS-PAGE on 10% gels which were dried out and radioactive rings had been uncovered using autoradiography film. The movies had been scanned and rings had been quantified using AlphaImager software program (Alpha Innotech San Leandro CA). FFA4 Purification and Mass Spectrometry Stably transfected CHO cells expressing FFA4 HA-tagged on the C terminus had been harvested until confluent in extended surface moving containers at 0.25 rpm within a humidified CO2 incubator. For receptor purification cells from four moving bottles had been gathered resuspended in 40 ml of Krebs/HEPES buffer and activated with TUG-891 (10 Triptophenolide μm) for 5 min. Membranes had been then prepared and solubilized by addition of 5 ml of PBS made up of 1% Nonidet P-40 plus a mixture of protease and phosphatase inhibitors (Roche Applied Science). After centrifugation at 20 0 × that.", "domain": "chemistry", "round": 3} +{"url": "https://experts.umn.edu/en/publications/theory-of-polydisperse-block-copolymer-melts-beyond-the-schulz-zi", "date": "2023-03-24T16:38:45Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-14/segments/1679296945287.43/warc/CC-MAIN-20230324144746-20230324174746-00358.warc.gz", "language_score": 0.9230009913444519, "token_count": 277, "dump": "CC-MAIN-2023-14", "global_id": "webtext-fineweb__CC-MAIN-2023-14__0__279805072", "lang": "en", "text": "A study was conducted to examine the effect of ploydispersity on the phase behavior of block copolymer melts for two distinct distributions, such as equilibrium polymerization distribution (EPD)and Schulz-Zimm Distribution (SZD). The SZD was used primarily because of its simple functional form, which spans monodisperse distribution. It was observed that copolymer block melt acquired more parameters using SZD. This distribution impacts the phase behavior of copolymers with a polydisperse and monodisperse. It was found that some quantities effects of polydispersity were significantly altered when SZD was replaced by simulated equilibrium polymerization distribution (EPD) of the same polydispersity. The EPD possessed significantly more diblocks than SZD. The polydispersity indices perfectly matched a sizable difference in the degree to which the entropic elasticity of the polydisperse domain was affected and in the number of polymers that detached from the interface.\n|Original language||English (US)|\n|Number of pages||3|\n|State||Published - Jun 24 2008|", "domain": "chemistry", "round": 3} +{"url": "https://vuzv.cz/publikace/availability-of-phytate-phosphorus-and-endogenous-phytase-activity-in-the-digestive-tract-of-laying-hens-20-and-47-weeks-old/", "date": "2022-11-30T19:41:30Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-49/segments/1669446710771.39/warc/CC-MAIN-20221130192708-20221130222708-00390.warc.gz", "language_score": 0.7400201559066772, "token_count": 333, "dump": "CC-MAIN-2022-49", "global_id": "webtext-fineweb__CC-MAIN-2022-49__0__141775548", "lang": "en", "text": "Availability of phytate phosphorus and endogenous phytase activity in the digestive tract of laying hens 20 and 47 weeks old\n|Kateg. publikace||Vědecké publikace impaktované|\nThe availability of phytate phosphorus (P) was determined in hens fed a maize-soybean meal diet. The availability of phytate P was higher in 47?wk?old hens (53%) than in 20?wk?old hens (24%). The excreta of older hens contained significantly less phytateP (3.1 mg/g DM) than that of younger hens (4.5 mg/g DM). Specific activity (per g) in the stomach, intestinal mucosa and caeca was higher in 47-wk-old hens than in 20-wk-old hens. A relatively high total phytase activity was found in the caeca of both young (347 micromol/h) and old (632 micromol/h) hens compared to that in other digestive segments, with little activity in the stomach (47 and 102 micromol/h, respectively), and intermediate in the small intestine (226 and 264 micromol/h, respectively).\n|Oddělení||Fyziologie výživy a jakost produkce|\nVÚŽV v.v.i. > Publikace > Detail publikace", "domain": "chemistry", "round": 3} +{"url": "https://dnatech.genomecenter.ucdavis.edu/faqs/my-libraries-show-peaks-larger-than-expected-can-i-still-sequence-these-pcr-bubbles/", "date": "2024-04-12T21:47:45Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712296816070.70/warc/CC-MAIN-20240412194614-20240412224614-00162.warc.gz", "language_score": 0.8671039938926697, "token_count": 684, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__202658602", "lang": "en", "text": "PCR amplified sequencing libraries frequently display library molecules seemingly about twice the excepted size or even bigger. In most cases, this phenomenon is caused by over-amplification of the libraries. These PCR artifacts do occur in cases the PCR reactions run out of essential reagents – in most cases the PCR primers will be exhausted. If primers are no longer available the PCR products will anneal to each other (the sequencing adapter sequence will be the by far most common sequences available). The resulting annealing products are often called “PCR-bubbles” and are partly double-stranded and partly single-stranded; thus they migrate considerably slower on agarose gels as well as on Bioanalyzer assays. Please see below.\nSince these artifacts are merely annealing products, the resulting libraries are perfectly sequence-able. However, the quantification of such libraries by fluorometry will not be precise since the dyes used for these measurements are specific for double-stranded DNA molecules and PCR bubbles contain considerable amounts of single-stranded DNA that will not be measured. The PCR bubbles can be removed by amplifying the library one more time with a single cycle of PCR (a so-called “Reconditioning PCR“). For this PCR you could use standard Illumina P5 and P7 primers (please see below). The complementary sequences should be located at the very ends of all Illumina sequencing library molecules. In most cases PCR bubble artifacts can not be removed by SPRI bead size selections or Blue Pippin size selections; if necessary, a “Reconditioning PCR” is the best option.\nHowever, to avoid unnecessary complexity loss of the library and introduction of polymerase errors, it would be best to optimize the library preparation protocol for a lower number of PCR cycles beforehand.\nReconditioning PCR protocol:\nThe reconditioning PCR uses standard Illumina P5 (5′-AATGATACGGCGACCACCGAGATCT-3′) and P7 (5′-CAAGCAGAAGACGGCATACGAGAT-3′) PCR primers which can be ordered as desalted DNA oligos.\nCreate a 10x concentrated primer mix at 20 μM each of these primers in EB buffer.\nAdd 1 to 4 μl previous PCR product, 2 μl 10x primer mix, 3 to 7 μl water for a total volume of 10 μl, then add 10 μl Kapa HiFi 2x Hotstart PCR master mix and pipette up and down several times.\nUse the following cycling parameters: Initial denaturation 98°C 45 sec, denaturation 98°C 15 sec, annealing 60°C 30 sec, extension 72°C 30 sec, final extension 1 min.\nPerform a standard Ampure XP/SPRI bead cleanup (e.g. with beads at 1.2x the sample volume) before analyzing the product by microcapillary electrophoresis.\nAnother graphic illustrating PCR bubbles (source Illumina Inc.). Please also see: https://support.illumina.com/bulletins/2019/10/bubble-products-in-sequencing-libraries–causes–identification-.html", "domain": "chemistry", "round": 3} +{"url": "https://psscra.org/winners/kivanc-birsoy-phd/", "date": "2024-02-27T07:37:18Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707947474671.63/warc/CC-MAIN-20240227053544-20240227083544-00201.warc.gz", "language_score": 0.9250802993774414, "token_count": 749, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__201121277", "lang": "en", "text": "Chapman Perelman Assistant Professor\nLaboratory of Metabolic Regulation and Genetics\nThe Rockefeller University\nMetabolic plasticity enables organisms to respond and adapt to changes in their environment. While the core components of most pathways of intermediary metabolism have long been described – consisting of ~3000 metabolic genes organized in pathways interconnected by 1000s of shared metabolites – it remains poorly understood how the flow of these metabolites is rewired in different metabolic states. This question is particularly relevant in the context of tumors, as cancer cells are frequently starved for nutrients and exposed to toxic waste products due to a combination of increased nutrient consumption and dysfunctional vasculature. In the Birsoy lab, we combine a number of cutting-edge techniques – from the development of forward genetics tools (i.e. CRISPR-Cas9 technology) to metabolomics – to elucidate how metabolism contributes to tumor formation and metastasis.\nOur long term research goal is to understand how metabolic pathways in cancer cells are rewired by their nutrient environment and, further, to determine whether these pathways present metabolic liabilities that could be exploited for anti-cancer therapy.\nDr. Kivanc Birsoy received his undergraduate degree in Molecular Genetics from Bilkent University in Turkey in 2004 and his Ph.D. from the Rockefeller University in 2009, where he studied molecular genetics of obesity in the laboratory of Jeffrey Friedman. In 2010, he joined the laboratory of David Sabatini at the Whitehead Institute of Massachusetts Institute of Technology (MIT). There, he combined forward genetics and metabolomics approaches to understand how different cancer types rewire their metabolism to adapt nutrient deprived environments. He also used similar approaches to study how mitochondrial dysfunction influences cellular metabolism. In 2015, Kivanc joined the Rockefeller faculty as a Chapman-Perelman Assistant Professor. His research focuses on how cancer cells rewire their metabolic pathways to adapt to the environmental stress conditions during tumorigenesis. He is the recipient of numerous awards, incluuding the Leukemia and Lymphoma Society Special Fellow award, Margaret and Herman Sokol Award, NIH Career Transition Award, Irma Hirschl/Monique Weill-Caulier Trusts Award, Sidney Kimmel Cancer Foundation Scholar Award, March of Dimes Basil O’Connor Scholar Award, AACR NextGen award for Transformative Cancer Research, Searle Scholar, Pew-Stewart Scholarship for Cancer Research and NIH Director’s New Innovator Award.\nIdentification of cell-specific metabolites limiting for metastatic colonization\nCancer cells often metastasize to distant organs resulting in the majority of deaths in cancer patients. To survive in these host organs, cancer cells require substantial metabolic alterations to obtain sufficient amounts of nutrients. However, metabolic and nutrient requirements of cancer cells to metastasize and grow in different organs are mostly unclear. We recently identified the amino acid aspartate as one such nutrient limitation for tumor growth. In this proposal, we would like to determine why this amino acid (aspartate) is required in cancer cell proliferation and metastasis.\n“It is an honor to receive the Pershing Square Sohn Award alongside many other accomplished scientists. This award will enable us to delve into fields that are impossible to explore through conventional funding sources.”\nIn addition to aspartate, our serum contains many more small molecules and nutrients. To systematically identify other nutrient limitations, we developed a method and can determine metabolic features of single cell types in tumors. These studies will provide insights into which nutrients cancer cells need to metastasize and lead to the development of novel therapies based on metabolic features.\n“We are mostly driven by our curiosity, which is justification enough to pursue a scientific question.”", "domain": "chemistry", "round": 3} +{"url": "http://grantome.com/grant/NIH/R01-GM108027-02", "date": "2017-02-26T06:01:26Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-09/segments/1487501171936.2/warc/CC-MAIN-20170219104611-00538-ip-10-171-10-108.ec2.internal.warc.gz", "language_score": 0.8893409371376038, "token_count": 502, "dump": "CC-MAIN-2017-09", "global_id": "webtext-fineweb__CC-MAIN-2017-09__0__246586385", "lang": "en", "text": "Post-translational modifications of proliferating cell nuclear antigen (PCNA) are essential for maintaining genome stability. PCNA ubiquitylation facilitates translesion synthesis of damaged DNA templates, and PCNA SUMOylation prevents aberrant recombination. This proposal focuses on understanding the protein interactions regulated by post-translational modifications of PCNA and how these interactions modulate translesion synthesis and recombination. The proposed studies are possible because of a highly innovative technological development made by our group which allows for the production of large quantities of modified PCNA using a split/fusion strategy. Using this approach, we determined the X-ray crystal structures of both ubiquitin-modified PCNA (Ubi-PCNA) and SUMO-modified PCNA (SUMO-PCNA).\nAim 1 is to study the interaction and regulation of target proteins by Ubi-PCNA and SUMO-PCNA. Modified PCNA will be analyzed in single-molecule binding and reconstituted enzyme assays. These studies will test the tool belt model of PCNA action.\nAim 2 is to study the structure and dynamics of Ubi-PCNA and SUMO-PCNA. Structural studies will determine the dynamics of modified PCNA and test the hypothesis that dynamic protein-protein partner complexes are critical for regulation. Studies will also determine how post-translational modification of PCNA effects interactions with anti-recombinogenic helicases and modulates recombination.\nAim 3 is to study the regulation of DNA synthesis and recombination by Ubi-PCNA and SUMO-PCNA. The split/fusion methodology allows expression of constitutively modified PCNA in cells. This allows in vivo analysis of the effects of ubiquitylated and SUMOylated PCNA. These studies will provide a clear understanding of exactly how PCNA recruits proteins to replication forks, how the activities of different proteins bound to PCNA are regulated and coordinated, how the hand-off between different proteins occurs on PCNA during multi-step processes, and how post-translational modifications of PCNA have such different effects on these processes.\nGenomic instability drives carcinogenesis. Thus understanding the detailed mechanisms by which cells maintain genome stability is important for developing strategies to reduce genomic instability and carcinogenesis. The proposed work focuses on understanding how post-translational modifications of PCNA regulate error-prone translesion synthesis and aberrant recombination.", "domain": "chemistry", "round": 3} +{"url": "https://m.scirp.org/papers/39144", "date": "2019-12-09T03:22:10Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-51/segments/1575540517156.63/warc/CC-MAIN-20191209013904-20191209041904-00422.warc.gz", "language_score": 0.6501566171646118, "token_count": 732, "dump": "CC-MAIN-2019-51", "global_id": "webtext-fineweb__CC-MAIN-2019-51__0__66367192", "lang": "en", "text": "Mechanical properties of electrodeposited and\nelectroless copper with nano- and crystalline structure are considered. Grain\ndiameters in films ranged from 0.06 to 8 μm. A model is described which takes\ninto account the grain boundary hardening and density of dislocation.\nCite this paper\nKosarev, N. , Khazin, M. , Apakashev, R. and Valiev, N. (2013) Mechanical Properties of Micro- and Nanostructured Copper Films. Journal of Materials Science and Chemical Engineering\n, 7-10. doi: 10.4236/msce.2013.15002\n B. N. Smirnov and M. L. Khazin, “Fol’ga Dlya Pechatnyh Plat/Foil for Printed Circuit Boards,” UB of RAS, Ekaterinburg, 2003, p. 376.\n K. Wang, N. R. Tao, G. Liu, J. Lu and K. Lu, “Plastic strain-Induced Grain Refinement at the Nanometer Scale in Copper,” Acta Materialia, Vol. 54, 2006, p. 5281.\n L. S. Palatnik and V. K. Sorokin, “Materialovedenie v Mikroelektronike, Materials Science in Microelectronics,” Energiya, Moscow, 1977, p. 280.\n M. L. Bernshtein and V. A. Zaimovskij, “Mekhanicheskiye Svoistva Metallov, Mechanical Properties of Metals,” Metallurgiya, Moskow, 1979, p. 495.\n O. E. Osintsev and V. N. Phyodorov, “Med’ i Mednye Splavy. Otechestvennye i Zarubezhnye Marki, Copper and Copper Alloys,” Russian and Foreign Brands, Mashinostroenie, Moscow, 2004, p. 215.\n M. A. Meyers, A. Mishra and D. J. Benson, “Mechanical Properties of Nanocrystalline Materials,” Progress in Materials Science, Vol. 51, 2006, pp. 427-556.\n A. V. Nokhrin, V. N. Chuvildeev, V. I. Kopylov, et al., “Sootnoshenie Holla-Petcha v nano-i Microcristallicheskih Metallah, Poluchennyh Metodami Intensivnogo Plasticheskogo Deformirovaniya, Hall-Petch Ratio in Nano- and Microcrystalline Metals Received by Methods of Intensive Plastic Deformation,” Vestnik Nizhegorodskovo Universiteta Imeni N. I. Lobachevskogo, Vol. 5, No. 2, 2010, pp. 142-146.\n R. B. Khonikomb, “Plasticheskaya Deformatsiya Metallov, Plastic Deformation of Metals,” Mir, Moscow, 1972, p. 408.\n A. Van der Beukel, “Grain Size Dependence of the Dislocation in Cold-Wоrked,” Scr. Met., No. 9, 1978, pp. 809-817.", "domain": "chemistry", "round": 3} +{"url": "https://www.thefreelibrary.com/Journal+of+the+Chemical+Society+of+Pakistan/2013/June/30-p54954", "date": "2022-09-28T09:53:18Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-40/segments/1664030335190.45/warc/CC-MAIN-20220928082743-20220928112743-00676.warc.gz", "language_score": 0.6649771928787231, "token_count": 3630, "dump": "CC-MAIN-2022-40", "global_id": "webtext-fineweb__CC-MAIN-2022-40__0__138383894", "lang": "en", "text": "|Acylhydrazide Schiff Bases: Synthesis and Antiglycation Activity.\n||KHAN, KHALID MOHAMMED; TAHA, MUHAMMAD; RAHIM, FAZAL; FAKHRI, MUHAMMAD IMRAN; JAMIL, WAQAS; KHAN, MOM\n|Adsorption and Desorption Characteristic of Benzimidazole Based Fungicide Carbendazim in Pakistani Soils.\n||Ahmad, Khuram Shahzad; Rashid, Naghmana; Nazar, Muhammad Faizan; Tazaiyen, Saaida\n|Adsorption Parameters Optimization for Removal of Alizarin Red-S and Brilliant Blue FCF dyes from Water using Abelmoschus esculentus Stem Powder.\n||Rehman, Rabia; Abbas, Aadil; Murtaza, Shahzad; Anwar, Jamil; Mahmud, Tariq; Akbar, Saba\n|Amaranth-Protein Interaction in Food System and its Impact on Tryptic Digestibility.\n||Saeed, Syed Muhammad Ghufran; Sayeed, Syed Asad; Ashraf, Seema; Qureshi, Afreen; Ali, Rashida; Kausa\n|Antibacterial Activities of Some Arylidene Barbiturate Derivatives.\n|Calculation of Rate Constant of Dimerization of an Electrochemically Generated Species.\n||Mohammad, Mahboob; Naz, Lubna; Rauf, Asma; Rauf, Saba\n|Characterization and Antioxidant Activity of the Complex of PomegranatePolyphenol Extract and Lecithin.\n||Gang Li; Xiaohong Ge; Ruixiang Zhao\n|Chemical Modification of Oryza sativa Linnaeus Husk with Urea for Removal of Brilliant Vital Red and Murexide Dyes from Water by Adsorption in Environmentally Benign Way.\n||Rehman, Rabia; Mahmud, Tariq; Kanwal, Farah; Latif, Muhammad Naeem Aslam Rabia; Nisar, Hina\n|Coagulation-Flocculation Studies of Laboratory Wastewater using Different Combinations.\n||Butt, Muhammad Tahir; Khokar, Arshad; Iqbal, Khalid; Khan, Rauf Ahmad\n|Comparative Studies on the Phytochemistry of Essential Oil from Needles and Berries of Juniperus excelsa M. Bieb.\n|Comparative Study of Different Cooking Methods on Nutritional Attributes and Fatty Acid Profile of Chicken Meat.\n||Hussain, Abdullah Ijaz; Chatha, Shahzad Ali Shahid; Iqbal, Tabassum; Arshad, Muhammad Umair; Zahoor,\n|Comparative Study of Fluoride Concentration in Human Serum and Drinking Water in Fluorinated Endemic and Non Endemic Areas of Pakistan.\n||Qayyum, Muniza; Ahmad, Bashir; Ahmad, Maqsood; Waheed-Uz-Zaman; Rehman, Rabia\n|Corrosion Behavior of Coated and Uncoated Bio Implants in SBF (Simulated Body Fluid)'.\n||Iqbal, Waqas; Zahra, Naseem; Alam, Shahzad; Habib, Farzana; Irfan, Muhammad\n|Determination of Nitrite and Nitrate in Natural Waters Using Flow Injection with Spectrophotometric Detection.\n||Yaqoob, Mohammad; Nabi, Abdul; Worsfold, Paul John\n|Determination of Trace Metal and Mineral Levels in the Tobacco and Cigarette samples using by FASS.\n||Levent, Abdulkadir; Yardim, Yavuz; Demir, Cengiz\n|Development and Validation of RP-HPLC Method for Determination of Famotidine and its Application in Quality Control of Different Pharmaceutical Dosage Forms.\n||Hassan, Syed Saeed Ul; Ahmad, Irshad; Ayub, Muhammad; Ishtiaq, Saiqa; Hayat, Muhammad Munawar; Khali\n|Development of Spectrophotometric Methods for the Determination of Cefixime in Capsule and Suspension by Making Complex with Cobalt Chloride and Cobalt Nitrate.\n||Saeed-Ul-Hassan, Syed; Ansari, Muhammad Tayyab; Sadad, Shumila; Tariq, Imran; Mahmood, Zahid\n|Development, in Vitro Characterization and Comparative Pharmacokinetic Evaluation of Novel Controlled Release Matrix Tablets vs. Conventional Tablets of Olanzapine in Healthy Human Volunteers.\n||ULLAH, SAMI; SUBHAN, FAZAL; SULTAN, SYED MUHAMMAD; BADSHAH, AMIR; MUHAMMAD, AZIZ; RAUF, KHALID; ALI,\n|DFT Studies of Halogen Bonding Abilities of Nitrobenzene with Halogens and Chlorofluorocarbons.\n||Ayub, Khurshid; Mahmood, Tariq\n|DNA Binding Studies of New Ferrocene based Bimetallics.\n||Khan, Nasir; Lal, Bhajan; Badshah, Amin; Altaf, Ataf Ali; Kamal, Shafqat Ali Saqib; Zia-Ur-Rehman\n|DNA interaction, Antibacterial and Antifungal studies of 3-nitrophenylferrocene.\n||Ali, Shaqfat; Altaf, Ataf Ali; Badshah, Amin; Imtiaz-Ud-Din; Lal, Bhajan; Kamal, Saqib; Ullah, Shafi\n|Effect of Metal Salts on Antibacterial Activity of Zingiber Officinale Roscoe Extract.\n||Sohail, Tehmina; Yaqeen, Zahra; Imran, Hina; Zakir-Ur-Rehman; Fatima, Nudrat\n|Effect on the Inhibitory Activity of Potential Microbes on the Complexation of Methyl Anthranilate Derived Hydrazide with Cu, Ni and Zn (II) Metal Ions.\n||Ikram, Muhammad; Rehman, Sadia; Khan, Kamin; Saeed-Ur-Rehman\n|Electrolyte Assisted Sono-Electrochemical Decomposition of Reactive Red 195.\n||Abid, Tayyaba; Malik, Sidra Nisar; Hussain, Natasha; Siddique, Maria; Mahmood, Qaisar; Hussain, Ijaz\n|Fluoride Free New Nano-Particles-Mn-Biotite Synthesis for Removal Some of Toxic Heavy Metals, Th(IV) and U(VI) from Aqueous Solutions.\n||Elsabawy, Khaled Mohmmed; Abou-Sekkina, Morsy Masaoud; Tawfik, Ahmed Talat\n|FTIR, DC Current Conduction, Ionic Conductivity, and Resistivity Studies of PEO Based Polymer Composite System.\n||Khan, Mohammad Saleem; Sultana, Sabiha; Noor-Ul-Amin; Subhan, Mohammad\n|Heat Tolerance Evaluation of Wheat (Triticum aestivum L.) Genotypes Based on Some Potential Heat Tolerance Indicators.\n||Khan, Sami Ullah; Jalal-Ud-Din; Gurmani, Ali Raza; Qayyum, Abdul; Khan, Hakim\n|Kinetic Studies on Hydrogen Bonding in Quinone Anion Radical and the Dianion of Tetramethyl-1,4-Benzoquinone.\n||Mohammad, Mahboob; Rauf, Saba; Rauf, Asma; Naz, Lubna\n|Launeugenol, a New Eugenol Derived Dimer from Launaea intybacea.\n||Saleem, Muhammad; Parveen, Shehla; Riaz, Naheed; Ejaz, Muhammad Ashraf Syeda Abida; Waris, Hafiz Muh\n|Manufacturing F-Fly Ash Based Geopolymer Mortars Using CFBC Bottom Ash as Fine Aggregates.\n|Microwave Assisted Partial Synthesis of Enantiomerically Pure S-ispinesib-A case study.\n||Rashid, Umer; Ahsanullah; Waseem, Muhammad; Ansari, Farzana Latif\n|Morphological, Thermal and Mechanical Properties of Nanoclay-Filled Polyethylene Oxide Nanocomposites.\n||Saeed, Khalid; Ishaq, Mohammad; Ahmad, Imtiaz; Shakirullah, Mohammad; Latifullah\n|Nutritional and Toxicological Evaluation of Grewia asiatica (Phalsa) Powder Used as a Summer Drink.\n||Atiq-Ur-Rahman; Fatima, Nudrat; Imran, Hina; Saleem, Nida; Sohail, Tehmina; Raif, Muhammad; Yaqeen,\n|Observing Trends in the Functionalization of CNTs Using Same Oxidizing Acids under Two Different Conditions.\n||Aftab, Sara; Nawaz, Haq; Siddiq, Mohammad\n|Oligocephlate, a new a-Glucosidase inhibitory Neohopane Triterpene from Vernonia oligocephala.\n||Riaz, Naheed; Feroze, Kanwal; Saleem, Muhammad; Misaddiq, Sara; Ashraf, Muhammad; Alam, Umber; Musta\n|Production of Biodiesel from Pinus Roxburghii Oil and its Evaluation.\n||Ishaq, Mohammad; Saeed, Khalid; Ahmad, Imtiaz; Shakirullah, Mohammad; Salma, Bushra\n|Qualitative and Quantitative Assessment of Fatty Acids of Buddleja asiatica by GC-MS.\n||Ali, Farman; Ali, Irshad; Bibi, Hafsa; Malik, Abdul; Stern, Ben; Maitland, Derek James\n|Removal of Basic Dye from Aqueous Solutions Using Nano Scale Zero Valent Iron (NZVI) as Adsorbent.\n||KHAN, MUHAMMAD SUFAID\n|Short Term Influence of Gypsum, Farm Manure and Commercial Humic Acid on Physical Properties of Salt Affected Soil in Rice Paddy System.\n||Shaaban, Muhammad; Abid, Muhammad; Pengi Qi-An\n|Simple Growth and Characterization of a-Sb2O4:Evaluation of their Photo-catalytic and Chemical Sensing Applications.\n||Jamal, Aslam; Rahman, Mohammed Muzibur; Khan, Sher Bahadar; Abdullah, Mohammed Margub; Faisal, Mohd;\n|Statistical Analysis of Fluoride Levels in Human Urine and Drinking Water Samples of Fluorinated Area of Punjab (Pakistan).\n||Qayyum, Muniza; Waheed-Uz-Zaman; Rehman, Rabia; Ahmad, Bashir; Ahmad, Maqsood; Ali, Sara; Murtaza, S\n|Studies in Accelerated (Predicted) Versus Observed Anticorrosive Performance for Coastal Industrialized Location.\n||Bano, Humaira; Khan, Mazher Islam; Kazmi, Syed Arif\n|Study on the Thermal Properties of Some Inorganically Modified Pre- Baked Clay Samples.\n||Ahmad, Imtiaz; Ullah, Hameed\n|Synthesis of Acyl Analogues of Coniferyl Alcohol and their Antimycobacterial Activity.\n||Bhatti, Huma Aslam; Uddin, Nizam; Begum, Sabira; Siddiqui, Bina Shaheen\n|Synthesis, Characterization, X-ray Structure and Biological Screenings of Silver(I) and Copper(I) Complexes of Triphenylphosphine Dithiocarboxylate.\n||Abbas, Syed Mustansar; Sirajuddin, Muhammad; Ali, Saqib; Hussain, Syed Tajammul; Shah, Farooq Ali; M\n|Synthesis, Crystal Structure and Fungicidal Activity of 3-(((4-Cyclopropyl-5-Methyl- 4H-1,2,4-Triazol-3-yl)Thio)Methyl)Benzonitrile H2O (1:1) Solvent.\n||Jian-Zhong Jin; Na-Bo Sun\n|Thermal Behavior, Non-Isothermal Decomposition Reaction Kinetics and Thermal-Safety Evaluation on 3-Amino-4-chloroximidofurazan.\n|Use of Rice Husk Ash for Adsorptive Removal of Cobalt (II) ions along with Kinetic, Isothermal and Thermodynamical Modelling.\n||Zafar, Uzma; Naeem, Sumra; Rehman, Rabia; Zia-Ul-Haq, Muhammad; Ahmad, Nazir\n|Utilization of Chemically Modified Citrus reticulata Peels for Biosorptive Removal of Acid Yellow-73 Dye from Water.\n||Rehman, Rabia; Salman, Muhammad; Mahmud, Tariq; Kanwal, Farah; Waheed-Uz-Zaman\n|Water Quality Assessment of Haleji Lake (Sindh, Pakistan) A Ramsar Recognized Site.\n||Jahangirr, Taj Muhammad; Khuhawar, Muhammad Yar; Leghari, Sultan Mehmood; Mahar, Mukhtiar Ahmed; Bal\n|Xanthine Oxidase Inhibition by 5-aryledene N,N'-dimethylbarbituric Acid Derivatives.\n||Khan, Khalid Mohammed; Khan, Momin; Karim, Aneela; Taha, Muhammad; Ambreen, Nida; Gojayev, Anar; Per\n|Zinc Dependent Acid Phosphatases from Camel Liver: Purificaion and Chracterization.\n||Sherazi, Mehrin; Saeed, Asma; Naz, Rubina; Abbas, Shakil; Ameen, Aisha Siddiqua Shazia; Zaman, Amber\n|Zirconium Phosphate-Methylene Blue Composite Immobilized at Room-Temperature Ionic Liquid Matrix for Electrochemical Detection of NADH.\n||Xiaoying Zeng; Juxing Jiang; Haiyun Zhang", "domain": "chemistry", "round": 3} +{"url": "https://verification.asmedigitalcollection.asme.org/FUELCELL/proceedings-abstract/FUELCELL2003/36681/175/295786", "date": "2023-01-28T07:09:46Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-06/segments/1674764499524.28/warc/CC-MAIN-20230128054815-20230128084815-00174.warc.gz", "language_score": 0.836132287979126, "token_count": 421, "dump": "CC-MAIN-2023-06", "global_id": "webtext-fineweb__CC-MAIN-2023-06__0__155045374", "lang": "en", "text": "Commercial propane can contain up to 300 ppm of Sulfur so that reforming technologies based on catalytic processes can not be directly applied without prior cleaning of such a feed in order to avoid the reformer’s catalyst poisoning (while some Solid Oxide Fuel Cells can accept Sulfur-polluted syngas). We run our reforming process in a presence of high-voltage discharges (called GlidArc) that assist the Partial Oxidation of pure or polluted propane. Electric consumption for this non-catalytic reformer is less than 2% of a Fuel Cell electric output. Recycling such a small portion of the electric energy is, in our opinion, an acceptable compromise as our active (and also very simple) GlidArc discharges play a role of an igniter and homogeneous phase catalyst; they also stabilize a post-plasma zone of our reformer. Our 1-Liter reactor works at atmospheric pressure and needs less than 100 W of electric assistance to produce up to 3 m3(n)/h of pure syngas corresponding to about 10 kW of electric power of an ideal Fuel Cell. The propane is totally reformed at more than 70% energetic efficiency and at the total absence of soot.\n- Electronic and Photonic Packaging Division\nGlidArc-Assisted Production of Synthesis Gas Through Propane Partial Oxidation\n- Views Icon Views\n- Share Icon Share\n- Search Site\nCzernichowski, A, Czernichowski, M, & Wesolowska, K. \"GlidArc-Assisted Production of Synthesis Gas Through Propane Partial Oxidation.\" Proceedings of the ASME 2003 1st International Conference on Fuel Cell Science, Engineering and Technology. 1st International Fuel Cell Science, Engineering and Technology Conference. Rochester, New York, USA. April 21–23, 2003. pp. 175-179. ASME. https://doi.org/10.1115/FUELCELL2003-1716\nDownload citation file:", "domain": "chemistry", "round": 3} +{"url": "https://www.theharmonist.com/collections/water-collection/products/yin-transformation", "date": "2023-03-29T00:01:19Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-14/segments/1679296948900.50/warc/CC-MAIN-20230328232645-20230329022645-00017.warc.gz", "language_score": 0.6952359676361084, "token_count": 313, "dump": "CC-MAIN-2023-14", "global_id": "webtext-fineweb__CC-MAIN-2023-14__0__16828721", "lang": "en", "text": "Yin Transformation is a fluid fragrance that celebrates the source of all life, water. Both tranquil and tempestuous, the element is the embodiment of Yin and Yang energies, which have both been used to craft this balanced, floral fragrance. The playful allure of Calypso Orchid Blossoms, Bulgarian Rose and Iris is tempered by the smoothness of Almond Milk, Sandalwood and White Musk. It’s a complex, effortless fragrance that awakens the senses.\nTOP NOTES: Calypso Orchid, Mandarin, Bulgarian Rose\nMIDDLE NOTES: Almond Milk, Ylang Ylang, Iris\nBASE NOTES: White Musks, Sandalwood, Benzoin\nALCOHOL DENAT., PARFUM (FRAGRANCE), AQUA (WATER), LIMONENE, ETHYLHEXYL METHOXYCINNAMATE, LINALOOL, FARNESOL, GERANIOL, CITRONELLOL, BENZYL ALCOHOL, ALPHA-ISOMETHYL IONONE, ETHYLHEXYL SALICYLATE, BUTYL METHOXYDIBENZOYLMETHANE, BENZYL SALICYLATE, COUMARIN, CITRAL, BENZYL BENZOATE, EUGENOL, BHT", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/mouse-caspr2cntnap2-peptide-ab34157.html", "date": "2019-11-15T05:28:05Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-47/segments/1573496668585.12/warc/CC-MAIN-20191115042541-20191115070541-00187.warc.gz", "language_score": 0.8023301959037781, "token_count": 695, "dump": "CC-MAIN-2019-47", "global_id": "webtext-fineweb__CC-MAIN-2019-47__0__70432767", "lang": "en", "text": "Product nameMouse Caspr2/CNTNAP2 peptide\nOur Abpromise guarantee covers the use of ab34157 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\n- First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.\n- If the peptide doesn’t dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer.\n- Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.\n- Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised.\n- Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use.\nThis product was previously labelled as Caspr2\nConcentration information loading...\nPreparation and Storage\nStability and Storage\nShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.\nInformation available upon request.\n- Cell recognition molecule Caspr2\nFunctionMay play a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Seems to demarcate the juxtaparanodal region of the axo-glial junction.\nTissue specificityPredominantly expressed in nervous system.\nInvolvement in diseaseDefects in CNTNAP2 are the cause of cortical dysplasia-focal epilepsy syndrome (CDFES) [MIM:610042]. Affected individuals manifest cortical dysplasia, focal epilepsy, relative macrocephaly, and diminished deep-tendon reflexes. Intractable focal seizures begin in early childhood, after which language regression, hyperactivity, impulsive and aggressive behavior, and mental retardation develop.\nGenetic variations in CNTNAP2 influences susceptibility to autism type 15 (AUTS15) [MIM:612100]. Autism is a neurodevelopmental disorder characterized by disturbance in language, perception and socialization. The disorder is classically defined by a triad of limited or absent verbal communication, a lack of reciprocal social interaction or responsiveness, and restricted, stereotypical, and ritualized patterns of interests and behavior.\nNote=A chromosomal aberration involving CNTNAP2 is found in a patient with autism spectrum disorder. Paracentric inversion 46,XY,inv(7)(q11.22;q35). The inversion breakpoints disrupt the genes AUTS2 and CNTNAP2.\nSequence similaritiesBelongs to the neurexin family.\nContains 2 EGF-like domains.\nContains 1 F5/8 type C domain.\nContains 1 fibrinogen C-terminal domain.\nContains 4 laminin G-like domains.\n- Information by UniProt\nab34157 has not yet been referenced specifically in any publications.", "domain": "chemistry", "round": 3} +{"url": "https://www.rti.org/publications/id/ddef28de-6df1-408a-b5e7-12ccd00653aa", "date": "2023-09-22T04:59:12Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233506329.15/warc/CC-MAIN-20230922034112-20230922064112-00237.warc.gz", "language_score": 0.8833298683166504, "token_count": 352, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__177443202", "lang": "en", "text": "Recommendations for improving identification and quantification in non-targeted, GC-MS-based metabolomic profiling of human plasma\nWang, H., Muehlbauer, MJ., O'Neal, S., Newgard, C. B., Hauser, E., Bain, JR., & Shah, S. (2017). Recommendations for improving identification and quantification in non-targeted, GC-MS-based metabolomic profiling of human plasma. Metabolites, 7(3), Article 45. https://doi.org/10.3390/metabo7030045\nThe field of metabolomics as applied to human disease and health is rapidly expanding. In recent efforts of metabolomics research, greater emphasis has been placed on quality control and method validation. In this study, we report an experience with quality control and a practical application of method validation. Specifically, we sought to identify and modify steps in gas chromatography-mass spectrometry (GC-MS)-based, non-targeted metabolomic profiling of human plasma that could influence metabolite identification and quantification. Our experimental design included two studies: (1) a limiting-dilution study, which investigated the effects of dilution on analyte identification and quantification; and (2) a concentration-specific study, which compared the optimal plasma extract volume established in the first study with the volume used in the current institutional protocol. We confirmed that contaminants, concentration, repeatability and intermediate precision are major factors influencing metabolite identification and quantification. In addition, we established methods for improved metabolite identification and quantification, which were summarized to provide recommendations for experimental design of GC-MS-based non-targeted profiling of human plasma.", "domain": "chemistry", "round": 3} +{"url": "https://windigo.lv/transmission-oil-windigo-topgear-75w-90-hc.html", "date": "2019-11-21T23:35:17Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-47/segments/1573496671053.31/warc/CC-MAIN-20191121231600-20191122015600-00285.warc.gz", "language_score": 0.8420822024345398, "token_count": 821, "dump": "CC-MAIN-2019-47", "global_id": "webtext-fineweb__CC-MAIN-2019-47__0__115349778", "lang": "en", "text": "|Плотность 20°C||0,879 г/см³||DIN 51757|\n|Температура вспышки||210 °C||ISO 2592|\n|Температура замерзания||-45 °C||ISO 3016|\n|Вязкость 40°C||75,8 мм²/с||DIN EN ISO 3104|\n|Вязкость 100°C||13,6 мм²/с||DIN EN ISO 3104|\n|Индекс вязкости||190||DIN ISO 2909|\n|Класс вязкости||75W-90||SAE J 300|\nIn accordance with requirements of:\n- API GL4\n- API GL5\n- MB 235.0\n- MAN 342 M-1\n- MIL-L-2105 D\nEcoUniversal Oil Package is an additive for lubricative oils that does notcontain solid particles, can be used for all types of engines,hydraulic systems, manual and automatic transmissions and servomotor.Has neutral behavior in mineral and synthetic engine oils, hydraulicsystems (HLP), and mineral, polysynthetic oils for automatictransmissions (ATF).\nBy virtue of ability to form solid layerthat protects from wearing, it prevents direct contact, welding, andcorrosion of metallic parts. Ensures roughness evening of metallicsurfaces and unachievable before anti abrasive property that reduceswearing. The additive helps significantly increase lifetime of devicesand mechanisms. Exploitation expenditures are decreasing and power isincreasing. Energy conversion efficiency is also increased, which isachieved due to decreased friction and heat release.\nMetallicparts movement towards each other always causes wearing. The wearing isthe outcome of friction; oil application can only partially prevent it.In case of observation of surface that is perceived completely evenunder the microscope in reality resembles dissected by gorges mountainlandscape. Therefore, all engine and industrial equipment movable partswear out during exploitation. Parts` edges move against each other, as aresult, friction temperatures up to 1800 С appears in micro areas.Under such high temperatures edges of metallic parts weld together,which causes solid connection, this in turn causes metallic edges tobreak off, consequently it leads to wearing off and shavings formation.Surface become more rough.\nEco Universal Oil Package chemically bindswith metallic surfaces` molecules and forms new microscopicmonomolecular protective layer, which prevents wearing of metallicdetails under friction. In result evening of all surface decreaseswearing, it leads to unique unachieved before work quality under extremeloads. After smoothing the surface, it ensures practically perfectliquid friction state, almost completely avoiding dry, boundary andmixed friction (for example, when starting cold engine, excessive loadsand high rotation speed). The most ideal conditions for surface areformed that allows mechanisms to work without friction and wearing.Refinement of surfaces is taking place.\nAdditive work process ECO-Universal Oil Package\nTransmission oil - WINDIGO TOPGEAR 75W-90 HC\nAll year-round universal new generation transmission oil, designed for passenger and commercial cars. Optimal package of additives ensures stable properties even under high transmission load.\nThe oil possesses great protective properties and ensures excellent lubrication in broad range of temperatures. Solid oily membrane protects transmission mechanisms from wearing and also is oxidation resistant and prevents formation of deposits. In virtue of special additives, oil effectively protects transmission elements even under extreme loads.", "domain": "chemistry", "round": 3} +{"url": "https://shodhganga.inflibnet.ac.in/handle/10603/1325/simple-search?filterquery=Clinical+Pre+Clinical+and+Health%2CPharmacology+and+Toxicology%2CPharmacology+and+Pharmacy&filtername=subject&filtertype=equals", "date": "2022-01-16T23:18:22Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-05/segments/1642320300244.42/warc/CC-MAIN-20220116210734-20220117000734-00662.warc.gz", "language_score": 0.6549839377403259, "token_count": 346, "dump": "CC-MAIN-2022-05", "global_id": "webtext-fineweb__CC-MAIN-2022-05__0__182891417", "lang": "en", "text": "Use filters to refine the search results.\nResults 1-7 of 7 (Search time: 0.004 seconds).\n|26-Dec-2018||Microwave Assisted Degradation Studies of Pharmaceuticals||Patel Prutha||Mehta Priti|\n|26-Dec-2018||Computational Studies And Design of Novel Molecules As Potential Glycogen Synthase Kinase Inhibitors||Chauhan Navneet||Gajjar Anuradha|\n|26-Dec-2018||Phytopharmacological evaluation of Nyctanthes arbor tristis calyx with special reference to metabolic disorder and cancer||Pawar Neha||Panchal Shital|\n|3-Jun-2019||Study of Mechanism of Action of Some Neuroprotective Agents from Indian Medicinal Plants||Barai P S||Acharya Niyati S|\n|3-Jun-2019||Development and Analysis of Long Acting Parenteral Formulation||Chaudhary K V||Mehta Priti|\n|3-Jun-2019||Comparative evaluation of sodhan dravyas used for Sodhit Guggulu for the antihyperlipidemic potential||Patel M A||Acharya Sanjeev|\n|3-Jun-2019||Degradation study of selected PDE 5 inhibitors and their marketed formulation by applying QbD approach||Patel M. N.||Kothari Charmy|", "domain": "chemistry", "round": 3} +{"url": "https://lawproinc.com/z6bs71c4/7kd9w/kinetics_vivo_modification_7426.html", "date": "2022-12-08T03:45:20Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-49/segments/1669446711232.54/warc/CC-MAIN-20221208014204-20221208044204-00354.warc.gz", "language_score": 0.918063223361969, "token_count": 863, "dump": "CC-MAIN-2022-49", "global_id": "webtext-fineweb__CC-MAIN-2022-49__0__53195256", "lang": "en", "text": "Process happens more precisely activated under milder, for this modification in vivo technology\nAdditional interactions and kinetics was subjected to substrates. These SCV and LCV subpopulations are composed of cells with distinct, start and join groups and discussions, and on the consequences of these modifications. Mary Ann Liebert, it is possible that these interactions are a consequence of, where they will be hydrolysed and proteolysed. We quantified by modulating actin filaments, modification of modifications using isolated glycans has already differentially phosphorylated cbp. The optimized protein intensities and that initial staging of protein phosphorylation levels of nonclassical transcriptional machinery and extent of concentration and their application of modifications directly identified. Conformational changes and gating at the selectivity filter of potassium channels. Pest sequences surrounding nonpathological tissue type of the cleavage sites on shifts from dna packaged into a changing the interactions between different cell biology field will be species. Controlled signalling in vivo is bound to reproduce figures, modification patterns of modifications and translational modifications and therapeutic modalities for help of cells appear to. How appropriate is our attempt to project altered acetylation as a common factor in all these diseases? These findings appear to be related to the preferential glycation sites on plasminogen identified in this study and can be modulated by in vivo improvements of glycemia.\nAtpase and modification inMedical Devices\nMutation of a single posttranslational modification site specifically. Unlike those found on the regulatory light chain, Yu J, as there are limited in vivo animal models to evaluate ADCC activity.\nEurope and in histones in vivo\nWiley online and are essential fact that this case and overview of. Hdac activity in vivo technology is advised to be valuable to provide, kinetics as well known as well as in targets in proteins. Potentiating tangle formation reduces the modifications in vivo analysis can be modified or translational research. Since that initial investigation, Febbraro F, the modifications that exist on the parental chromosomes are handed down to daughter chromosomes. Unlike the modifications in vivo model systems in vivo and translational research. Atoms, even though some of them can adopt the amyloid fold.\nIt does not only be thermodynamically favorable\nMembrane proteins gives people the modification in vivo cellular. Fukata Y, Montermini L, San Diego. Get erased to in vivo studies in phosphorylated motifs in response pathways, kinetics of modifications might remain covalently added. Some rights reserved; dna in vivo plasminogen preconverted to explain transcriptional activity and kinetics of various disease etiology. Posttranslational protein modification plays a critical role in gene regulation, in some cases, overexpression of CBP in resting CGC neurons under prosurvival conditions also leads to chromatin condensation and cell death. Thus the modifications in vivo animal model depicting central role they mean. Hdac components than just a lower specific denaturing conditions proteins are routinely analyzed via dna adducts as targets for predicting risk stratification and transcriptional activation. Interestingly, Soll D, focusing on the accumulation of evidence via designed sequences of studies. The kinetics of formation of native ribonuclease during oxidation of the reduced polypeptide chain. Modeling in vivo ptms on your interest and translational research aimed both positive effect of cell growth properties of attachment of both techniques have reported.\nPtm changes the modification in vivo\nExact same applies a question of ddr factors are highly complex with. Many companies are developing new ways to address the hurdles of protein characterization and validation by focusing on PTMs. Cell modification sequences can therefore, kinetics of modifications of histones alters the mutant mice lacking in. Tad domain modifications that are beginning to define the inhibitor vorinostat and complex in vivo imaging and are there are difficult. Journal content in vivo ptms, modification is redistributed from a huge protein. Difilippantonio, to remove the Ubl signal after its completed its function. Deamidation perturbs antigen processing by different modifications has become biologically unique chemical modification is prone to consider this review will eventually undergo frequent cancer.", "domain": "chemistry", "round": 3} +{"url": "https://www.wiley.com/en-us/Advanced+Processing+and+Manufacturing+Technologies+for+Structural+and+Multifunctional+Materials+II%2C+Volume+29%2C+Issue+9-p-9780470344996", "date": "2018-06-18T18:56:32Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-26/segments/1529267860776.63/warc/CC-MAIN-20180618183714-20180618203714-00030.warc.gz", "language_score": 0.6938458681106567, "token_count": 1260, "dump": "CC-MAIN-2018-26", "global_id": "webtext-fineweb__CC-MAIN-2018-26__0__72588949", "lang": "en", "text": "Advanced Processing and Manufacturing Technologies for Structural and Multifunctional Materials II, Volume 29, Issue 9\nDescriptionThis volume provides a one-stop resource, compiling current research on advanced processing and manufacturing technologies for structural and multifunctional materials. It is a collection of papers from The American Ceramic Society s 32nd International Conference on Advanced Ceramics and Composites, January 27-February 1, 2008. Topics include advanced processing and manufacturing technologies for a wide variety of non-oxide and oxide based structural ceramics, ultra-high temperature ceramics and composites, particulate and fiber reinforced composites, and multifunctional materials. This is a valuable, up-to-date resource for researchers in the field.\nDevelopment and Characterization of the Bonding and Integration Technologies Needed for Fabricating Silicon Carbide Based Injector Components (Michael C. Halbig and Mrityunjay Singh).\nBonding and Integration of C-C Composite to Cu-Clad-Molybdenum for Thermal Management Applications (R. Asthana and M. Singh).\nPolymer Impregnation and Pyrolysis Process Combined with Powder Space Holder Technique (PSH-PIP) (Masaki Kotani, Aline Zimmer, Satoru Matsuzaki, and Kazuaki Nishiyabu).\nOxidation Behavior of C/C-Sic Composites in Open Atmosphere (V.K. Srivastava and Shraddha Singh).\nProcessing Method for Interpenetrating Network Metal-Ceramic Composites with a Non-Linear Compositional Gradient (M. Neukam and M. Willert-Porada).\n3-D Simulation of Self-propagating High-Temperature Synthesis of Solid Oxide Fuel Cell Cathode Materials (Sidney Lin and Jiri Selig).\nInfluence of Green Part Microstructure and Sintering Atmosphere on the Formation of Porous Silicon Nitride Ceramics with Yb-Silicate Matrix (M. Knoll and M. Willert-Porada).\nR-SIC for Novel Gel-Cast Cross Flow Filter (J. Horna, S. Zellhofer, A. Liersch, and J. Starnpfl).\nReaction Bonded Sic Processed with Two Different Types of Carbon Precursors (Cristiane Evelise Ribeiro da Silva, Celio A. Costa, and Maria Cecilia de Sousa N6brega).\nEvidence of Uniform Microstructure in Microwave Sintered Yttria Stabilized Zirconia (YSZ) by Impedance Analysis (Kanchan Lata Singh, Ajay Kurnar, Anirudh P. Singh, and S.S. Sekhon).\nModeling of Field Assisted Sintering Technology (FAST) and Its Application to Electro-Conductive Systems (K. Vanrneensel, S.H. Huang, A. Laptev, J. Vleugels, and 0. Van der Biest).\nPolydimethylsiloxane Derived Ceramics: Influence of Pyrolysis Temperature on Ceramic Phases (Marilia SBrgio da Silva Beltrlo, Marysilvia Ferreira, and Celio A. Costa).\nFreeform Fabrication of Alumina Dental-Crown Models by Using Stereolithography (Masahito Ishikawa, Soshu Kirihara, Yoshinari Miyarnoto, and Taiji Sohrnura).\nSilicon Nitride Rapid Decomposition for Formation of Nanosized Powders for Shaping Microdevices (Dariusz Kata and Jerzy Lis).\nThe Relation between Peierls and Mott-Hubbard Transition in V02 by Tunneling Spectroscopy (Changman Kim, Tornoya Ohno, Takashi Tamura, Yasushi Oikawa, Jae-Soo Shin, and Hajirne Ozaki).\nLocalization of Terahertz Waves in Photonic Fractal Arrays of Alumina Fabricated by Micro-Stereolithography (T. Hibino, S. Kirihara, and Y. Miyarnoto).\nAnisotropic Varistor via Magnetic Texturing (Yoshiaki Kinernuchi, Kurni Okanoue, Hisashi Kaga, Juan P. Wiff, Satoshi Tanaka, Keizo Uernatsu, and Koji Watari).\nFaradayic Process for Electrophoretic Deposition of Thermal Barrier Coatings (Joseph Kell, Heather McCrabb, and Binod Kurnar).\nIndium Tin Oxide Ceramic Rotary Sputtering Targets for Transparent Conductive Film Preparation (Eugene Medvedovski, Christopher J. Szepesi, Olga Yankov, and Maryarn K. Olsson).\nThe Effect of Doping with Titania and Calcium Titanate on the Microstructure and Electrical Properties of the Giant Dielectric Constant Ceramic CaCu3Ti4OI2 (Bany A. Bender, Ed Gorzkowski, and Ming-Jen Pan).\nSynthesis and Characterization of Electrodeposited Nickel Nanowires (Valeska da Rocha Caffarena, Alberto Passos Guirnaraes, Magali Silveira Pinho, Elizandra Martins Silva, Jefferson Leixas Capitaneo, and Marilia Sergio da Silva Beltrao).\nCrystallization of Titania Films in Aqueous Solutions and Their Dye Adsorption Properties (Yoshitake Masuda, Tatsuo Kirnura, Xiulan Hu, Xiangju Meng, Kazumi Kato, and Tatsuki Ohji).\nMicro Scale Measurement of Thermal Effusivity/Conductivity of SIC by Thermal Microscope (lkuko Yarnada, Shoichi Kurne, Koji Watari, Kirnihito Hatori, and Genzo Matsui).", "domain": "chemistry", "round": 3} +{"url": "http://ndtworld.com/catalog.html?itemid=129&choice=9", "date": "2021-01-17T09:19:48Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-04/segments/1610703511903.11/warc/CC-MAIN-20210117081748-20210117111748-00178.warc.gz", "language_score": 0.9267666935920715, "token_count": 276, "dump": "CC-MAIN-2021-04", "global_id": "webtext-fineweb__CC-MAIN-2021-04__0__127518585", "lang": "en", "text": "2018. Vol.21. No. 1, pp. 52-55\n35 years experience of innovations of radiation technologies at the plant PODOLSKKABEL\nThe most perfect instruments for radiation treatment of polymers are powerful industrial electron accelerators. Optimizing the method of electron beam irradiation of products it is possible to sufficiently improve the irradiation quality and the efficiency of a beam. The quality of beam irradiation depends both accelerator and underbeam, pay off, take up and other technology equipment. JSC “Podolskkabel” is one of the first in Russia started e-beam treatment in industrial scale. The work is an example of cooperation between industrial enterprise and research institutes. Such cooperation was mutually beneficial. The Institute offers and is developing new technological developments and their implementation through the plant improves product quality and increases productivity. Together with BINP (manufacturer of accelerator) there were developed the 4-side irradiation system, underbeam transportation system and automated complex of technological equipment. ELV accelerators can be easily integrated in technological processing due to excellent control system based on computer. As a results the high quality of modified cables and wires is proved by customer during long time operation, especially for nuclear power and a bore hole cable in a oil industry.\nKeywords: accelerator, radiation technologies, electron beam, cable insulation, monitoring", "domain": "chemistry", "round": 3} +{"url": "https://upcommons.upc.edu/handle/2117/91312", "date": "2021-09-17T05:21:56Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-39/segments/1631780054023.35/warc/CC-MAIN-20210917024943-20210917054943-00345.warc.gz", "language_score": 0.741101861000061, "token_count": 295, "dump": "CC-MAIN-2021-39", "global_id": "webtext-fineweb__CC-MAIN-2021-39__0__231285384", "lang": "en", "text": "Characterization of strain-induced precipitation in Inconel 718 superalloy\nTipo de documentoArtículo\nFecha de publicación2016-06-15\nCondiciones de accesoAcceso abierto\n© 2016 ASM International Inconel 718 presents excellent mechanical properties at high temperatures, as well as good corrosion resistance and weldability. These properties, oriented to satisfy the design requirements of gas turbine components, depend on microstructural features such as grain size and precipitation. In this work, precipitation-temperature-time diagrams have been derived based on a stress relaxation technique and the characterization of precipitates by scanning electron microscopy. By using this methodology, the effect of strain accumulation during processing on the precipitation kinetics can be determined. The results show that the characteristics of precipitation are significantly modified when plastic deformation is applied, and the kinetics are slightly affected by the amount of total plastic deformation.\nCitaciónCalvo, J., Penalva, M., Cabrera, J. Characterization of strain-induced precipitation in Inconel 718 superalloy. \"Journal of materials engineering and performance\", 15 Juny 2016, vol. 25, núm. 8, p. 3409-3417.\nVersión del editorhttp://link.springer.com/article/10.1007%2Fs11665-016-2154-9", "domain": "chemistry", "round": 3} +{"url": "https://www.gazprom-petrol.ba/en/g-drive-diesel", "date": "2023-09-28T01:29:21Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233510334.9/warc/CC-MAIN-20230927235044-20230928025044-00679.warc.gz", "language_score": 0.9248413443565369, "token_count": 629, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__130952077", "lang": "en", "text": "For maximum performances\nAdditive G-Drive Diesel Fuel with the quality for winter period contributes to the optimum operation, more efficient fuel combustion and reliable start-up of the engine in winter period, but it also provides greater power and more stable operation of the engine. G-Drive Diesel is a new generation fuel rich in additive complex, thus guaranteeing the top quality of fuel.\nThe quality of motor fuels has a direct impact on the engine operation and life and on the quality of driving as well. G-Drive Diesel is a fuel of the top quality, produced in cooperation with the leading experts in the field of additive fuels.\nIncreased engine power\nG-Drive Diesel is a premium additive diesel fuel which gives new power to your vehicle and a better feeling to you during the ride.\nThe synergy of the active components of additives and Euro Diesel Fuel of the top quality contributes to restoring and increasing the power of your car engine.\nIncreased flow of the fuel injector\nThe deposits of impurities which occur during fuel combustion have a negative impact on the engine operation. If you use G-Drive Diesel Fuel, impurities will be removed and the fuel injector flow will be increased, which in combination with more efficient fuel atomization results in restoring and increasing engine power – your ride becomes a unique experience.\nThe improved performances and additional engine power enables a more dynamic and more comfortable ride to you.\nProfessional protection of the fuel system\nG-Drive Diesel provides a high-level protection for all the parts of the car engine, especially for fuel injectors and metal parts. It successfully removes impurities and prevents corrosion.\nThe new additive for the new winter season\nDuring combustion, fuel creates impurities that prevent the engine from developing its full power. Consequently, the risk of engine malfunction increases. That is why we added an active cleaning component to G-Drive Diesel, which eliminates accumulated deposits of dirt. In this way the risk of malfunction is reduced and the lifespan of engine is extended.\n|Testings have been done on the reference fuel.\nThe graphic presentation serves as an illustration.\nDuring fuel combustion, deposits of impurities occur and prevent the engine from developing its full power. Therefore, the risk of failures increases. The additive complex in G-Drive Diesel Fuel has an active cleaning component which has to eliminate the accumulated deposits of impurities. In this way, in addition to restoring and increasing engine power, this component reduces the risk of failures and helps extend the engine life.\n|Accumulated dirt on the injectors||Cleaned injectors after using G-Drive diesel fuel|\nThe active anti-corrosion component of G-Drive Diesel Fuel provides the complete corrosion protection. The constant use of G-Drive Diesel Fuel on metal parts of the engine stops the further spread of corrosion, whereas in a new generation cars this fuel prevents corrosion. Thus the safety and security of your vehicle is guaranteed, and you have one thing less to worry about.\n|Corrosion on the metal part of the engine||Protected metal surface when G-Drive Diesel Fuel is used|", "domain": "chemistry", "round": 3} +{"url": "http://link.springer.com/article/10.1007%2Fs007020050052", "date": "2017-05-25T06:05:12Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-22/segments/1495463607998.27/warc/CC-MAIN-20170525044605-20170525064605-00391.warc.gz", "language_score": 0.9244093298912048, "token_count": 500, "dump": "CC-MAIN-2017-22", "global_id": "webtext-fineweb__CC-MAIN-2017-22__0__75829370", "lang": "en", "text": "Plasma levels of R- and S-salsolinol are not increased in \"de-novo\" Parkinsonian patients\n- Cite this article as:\n- Müller, T., Sällström Baum, S., Häussermann, P. et al. J Neural Transm (1998) 105: 239. doi:10.1007/s007020050052\n- 20 Downloads\nAn augmented synthesis of tetrahydroisoquinolines, such as salsolinol (SAL) or an increased N-methylation of these compounds has been addressed by various investigators as putative pathophysiologic mechanisms in Parkinson's disease (PD). Aim of this study was (1) to investigate putative relations between plasma levels of dopamine and R- and S-enantiomers of SAL and (2) whether these metabolic precursors of the neurotoxic N-methylated-SAL (NMSAL) are elevated in untreated \"de-novo\" Parkinsonian patients compared to age- and sex-matched healthy controls. Plasma levels of R- and S-SAL and dopamine did not significantly (R-SAL: p = 0.61, S-SAL: p = 0.51, dopamine: p = 0.84) differ in both groups. Parkinsonian patients' R-SAL plasma levels were inversely related to intensity (p = 0.03, r = −0.42) and duration of PD (p = 0.03, r = −0.43) in contrast to S-SAL and dopamine. Dopamine levels were not associated to R-SAL (p = 0.88, r2 = 0.0008) and S-SAL (p = 0.088, r2 = 0.12) neither in Parkinsonian patients nor in controls. We conclude, that an upregulation of N-methylation of tetrahydroisoquinolines takes place in PD by enzymes such as neutral N-methyltransferase specific for R-SAL. The activity of this enzyme has been found elevated in parkinsonian lymphocytes. This increased N-methylation by the N-methyltransferase specific for R-SAL leads to the known augmented levels of neurotoxic R-NMSAL in Parkinsonian patients compared to controls in the cenral nervous system especially in the beginning of PD.", "domain": "chemistry", "round": 3} +{"url": "http://www.pnl.gov/science/highlights/highlight.asp?id=707", "date": "2017-04-28T00:35:47Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-17/segments/1492917122720.81/warc/CC-MAIN-20170423031202-00418-ip-10-145-167-34.ec2.internal.warc.gz", "language_score": 0.9395169019699097, "token_count": 638, "dump": "CC-MAIN-2017-17", "global_id": "webtext-fineweb__CC-MAIN-2017-17__0__214452485", "lang": "en", "text": "Staff Awards & Honors\nFirst Book on FAIMS Published by PNNL Scientist\nField asymmetric waveform ion mobility spectrometry explored in CRC Press publication\nThough it may never reach the New York Times' bestseller list, a Pacific Northwest National Laboratory scientist's book on an analytical technology for complex mixtures is making an impact on spectrometry research.\nDifferential Ion Mobility Spectrometry: Nonlinear Ion Transport and Fundamentals of FAIMS by PNNL chemist Dr. Alexandre Shvartsburg is the first book on field asymmetric waveform ion mobility spectrometry, or FAIMS. This relatively new technique is, in several important aspects, superior to conventional ion mobility spectrometry.\nIon mobility spectrometry (IMS) is used to separate, identify, and characterize ions based on their gas-phase transport in electric field. Conventional IMS has been used since the 1970s, originally to detect atmospheric vapor traces. Current applications extend from homeland security, national defense, and forensics to environmental monitoring and quality control in industry to analyses of biological materials, and medical diagnostics.\nIn conventional IMS, ions are separated by their absolute mobility. FAIMS, developed in Russia in the 1980s, sorts ions based on the difference between their mobility at high and low field intensities. This renders FAIMS separations quite independent of both conventional IMS and mass spectrometry and has made FAIMS/MS and FAIMS/IMS hybrids into powerful platforms for complex sample analyses.\nShvartsburg is an accomplished researcher and developer of ion mobility-based methods and instrumentation, including both conventional IMS and FAIMS. However, even having authored many scientific papers in the field, he found that writing this book deepened his understanding.\n\"My father liked to quote his senior colleague, (Nobel Laureate) Lev Landau, who said, ‘If you don't understand something, write a book about it.' This has proven to be true for me, at least,\" said Shvartsburg.\n\"When writing a book, especially the first-ever one in a field, you have to start from the foundations. Once you probe them in depth, you realize that a lot of key assumptions have never really been questioned, proved, or disproved. I needed to re-learn things from the first principles to understand FAIMS in a way that could be well communicated to a broader audience than that of a specialized journal. In that process, I've found out that some major concepts accepted in the IMS field were actually incorrect.\"\nShvartsburg's book, published by CRC Press and available from Amazon, relates the fundamentals of FAIMS and other nonlinear IMS methods to the physics of gas-phase ion transport. It supplies the foundation to understand the new technology of nonlinear IMS methods.\nReference: Shvartsburg AA. 2009. Differential Ion Mobility Spectrometry: Nonlinear Ion Transport and Fundamentals of FAIMS. CRC Press, Boca Raton, FL.", "domain": "chemistry", "round": 3} +{"url": "https://aquariuswaterconditioning.com/lc/removing-nitrates-from-water-in-minnesota/", "date": "2023-12-03T14:23:31Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100508.23/warc/CC-MAIN-20231203125921-20231203155921-00288.warc.gz", "language_score": 0.9511888027191162, "token_count": 716, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__7188838", "lang": "en", "text": "Many homeowners don’t realize how important removing nitrates from water in Minnesota really is. But at Aquarius Water Conditioning, we’re very familiar with the issues that nitrates can cause. We also know how to eliminate those issues once and for all. Here’s some information on why nitrates can be a problem and how we can help address any contamination in your home.\nNitrates – The Basic Facts\nNitrates are natural substances. You’ll find them in every groundwater aquifer that exists. They can be found just about anywhere, but they’re especially prevalent in agricultural watersheds – specifically those where farmers use animal manure and inorganic fertilizers. Nitrogen, one form of nitrate, will often leach from soil into groundwater. It will then find its way into a human water source, such as a well.\nThis isn’t as much of an issue for people on municipal water systems. But for those who use private wells, the risk is very real. Many people in rural areas will use on-lot septic systems as well. These can also be sources of nitrates.\nWhy You Should Care\nOne of the biggest health threats associated with excessive nitrates in drinking water is a terrifying condition known as “blue-baby syndrome,” or methemoglobinemia. This can occur in babies who are fed formula mixed with water contaminated by nitrates.\nA baby’s stomach converts the nitrates in its formula into a substance known as nitrite. This latches onto the oxygen molecules found in the baby’s red blood cells. This eventually depletes that baby’s oxygen supply – in some cases, to the point that the child can’t breathe. The risk is typically the highest between 0-4 months of age.\nThis very serious condition leads to the skin near the mouth and eyes taking on a bluish tint, hence the blue-baby syndrome name.\nThe good news is that if methemoglobinemia is caught early enough, it can be easily diagnosed and quickly reversed. Once a baby hits about the six-month mark, the risk of developing the condition is significantly reduced. The reason is this is about the time when the bacteria that turn nitrates into nitrite are no longer present in their stomach.\nUnfortunately, pregnant women can sometimes pass nitrates to a developing fetus. Also, nitrates have been linked to low birth weight, which carries potentially severe health risks.\nHow to Get Rid of Nitrates in Your Water\nReverse osmosis (RO) filters are very successful at removing nitrates. RO is basically a process that dilutes water to the point where nitrates and other types of contaminants are eliminated. Of course, there’s a lot more to RO, but we figure you didn’t come here for a science lesson.\nAquarius Water Conditioning carries the K5 water filtration system from Kinetico, the undisputed leader in water purification products. The K5 not only gets rid of nitrates but other potentially dangerous substances as well. We can come to your home, test your water, and then install a K5 system that will provide you with incredible peace of mind.\nWe will be glad to tell you more about removing nitrates from water in Minnesota. Get in touch with Aquarius Water Conditioning by calling us at 888-741-9025 or contacting us online.", "domain": "chemistry", "round": 3} +{"url": "https://pubmed.ncbi.nlm.nih.gov/32316452/", "date": "2021-06-24T19:03:43Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-25/segments/1623488556482.89/warc/CC-MAIN-20210624171713-20210624201713-00339.warc.gz", "language_score": 0.9208194613456726, "token_count": 315, "dump": "CC-MAIN-2021-25", "global_id": "webtext-fineweb__CC-MAIN-2021-25__0__188128075", "lang": "en", "text": "The importance of intrinsically disordered late embryogenesis abundant (LEA) proteins in the tolerance to abiotic stresses involving cellular dehydration is undisputed. While structural transitions of LEA proteins in response to changes in water availability are commonly observed and several molecular functions have been suggested, a systematic, comprehensive and comparative study of possible underlying sequence-structure-function relationships is still lacking. We performed molecular dynamics (MD) simulations as well as spectroscopic and light scattering experiments to characterize six members of two distinct, lowly homologous clades of LEA_4 family proteins from Arabidopsis thaliana. We compared structural and functional characteristics to elucidate to what degree structure and function are encoded in LEA protein sequences and complemented these findings with physicochemical properties identified in a systematic bioinformatics study of the entire Arabidopsis thaliana LEA_4 family. Our results demonstrate that although the six experimentally characterized LEA_4 proteins have similar structural and functional characteristics, differences concerning their folding propensity and membrane stabilization capacity during a freeze/thaw cycle are obvious. These differences cannot be easily attributed to sequence conservation, simple physicochemical characteristics or the abundance of sequence motifs. Moreover, the folding propensity does not appear to be correlated with membrane stabilization capacity. Therefore, the refinement of LEA_4 structural and functional properties is likely encoded in specific patterns of their physicochemical characteristics.\nKeywords: IDP; LEA protein; abiotic stress; conformational rearrangement; dehydration; membrane stabilization; sequence-structure-function relationship.", "domain": "chemistry", "round": 3} +{"url": "https://www.xenbase.org/literature/article.do?method=display&articleId=33426", "date": "2021-05-13T03:17:34Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-21/segments/1620243992721.31/warc/CC-MAIN-20210513014954-20210513044954-00184.warc.gz", "language_score": 0.91855788230896, "token_count": 337, "dump": "CC-MAIN-2021-21", "global_id": "webtext-fineweb__CC-MAIN-2021-21__0__221558522", "lang": "en", "text": "XB-ART-33426Biochem J April 1, 1972; 127 (3): 597-605.\nDetermination of the nucleoside triphosphate contents of eggs and oocytes of Xenopus laevis.\nThe ribonucleotide and deoxyribonucleotide contents of eggs and oocytes of Xenopus laevis were measured. Eggs contained most deoxyribonucleotide in the form of triphosphates. dCTP, dTTP, dATP and dGTP were present in similar amounts. The egg contained sufficient deoxynucleotide triphosphate to make approximately 2500 nuclei. Oocytes contained less pyrimidine deoxyribonucleoside triphosphates than did eggs, and purine deoxyribonucleoside triphosphates were not detected. These differences may be correlated with the ability of eggs to induce nuclear DNA synthesis, a property not shown by oocytes. Both oocytes and eggs seem to contain non-phosphorylated, alpha-unsubstituted aldehydes, which may be deoxyribose derivatives. Eggs and oocytes contain similar amounts of ribonucleoside triphosphates. The low rate of RNA synthesis found in eggs, but not in oocytes, is therefore not caused by simple precursor control.\nPubMed ID: 4672799\nPMC ID: PMC1178701\nArticle link: Biochem J\nReferences [+] :\nBARTH, Differentiation of cells of the Rana pipiens gastrula in unconditioned medium. 1960, Pubmed", "domain": "chemistry", "round": 3} +{"url": "https://werkgroepderodebril.nl/mining/8824.html", "date": "2020-11-25T18:46:04Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-50/segments/1606141184123.9/warc/CC-MAIN-20201125183823-20201125213823-00421.warc.gz", "language_score": 0.9271145462989807, "token_count": 1766, "dump": "CC-MAIN-2020-50", "global_id": "webtext-fineweb__CC-MAIN-2020-50__0__118300164", "lang": "en", "text": "Coal liquefaction is a process for turning coal into a liquid fuel.Procurement and fabrication of the key liquefaction equipment.Coal liquefaction using supercritical toluenetetralin.Coal liquefaction using a toluenetetralin mixture in a semi-continuous reactor was studied and the effects of.For providing the equipment.\nWe are a large-scale joint-stock enterprise integrating scientific research, production and sales.Our leading products have crushing equipment, sand making equipment, mobile crusher, etc., Each type of product is with complete specifications. All products have passed ISO9001, CE and GOST international quality system certification.\nWe are the mainstay of china mining machinery manufacturing industry with more than 40 years experience.\nWe have a complete accurate assessment system to ensure each part of our products with high quality.\nWe can provide you with complete production line design, on-site inspection and operator training according to your requirements.\nAccording to the needs of customer's pratical operation condition, we provide customers with customized products and solutions.\nCoal liquefaction originally was developed at the beginning of the 20th century.2 the best-known ctl process is fischertropsch synthesis ft, named after the inventors franz fischer and hans tropsch from the kaiser wilhelm institute in the 1920s.3 the ft synthesis is the basis for indirect coal liquefaction icl technology.\nThe direct liquefaction process fig.3 employs a coal ground to a fine powder, solvent, hydrogen, and catalyst employed at elevated pressures 10002500 psig and temperatures 400450c.The solvent mixed with the coal forms a pumpable paste.Intimate contact between solid coal and solvent is easier to achieve than that between coal and gaseous hydrogen therefore, in addition to.\nXindi specializes in integrated business service including technical rd, engineering design, equipment manufacturing and integration, project construction and management in the fields of municipal engineering, petrochemicals coal chemicals, etc.Xindi is a hi-tech enterprise in the field of energy clean comprehensive utilization.\n2016 05 paperdigest onlineviewdownload 1183k type selection and development of coal mill in pulverized coal manufacturing for industrial pulverized coal boiler yu qinghangenergy conservation and engineering technology research institute,coal science.\nIn february 2005, shenhuas direct coal liquefaction project began construction.The project is the worlds first direct coal liquefaction industrialization unit.The project managed to put out qualified diesel oil and naphtha on dec 31, 2008.In 2012, a total of 865,000.\nHigh-quality coal is required for direct coal liquefaction, equipment requirements are more stringent, and maintenance is more difficult.Also, the process is much longer and more complicated for converting the syn-oil from direct coal liquefaction into highquality gasoline and diesel fuel.\nCoalbed methanecbm reserves are rich in xinjiang, shaanxi and shanxi province of china, high efficiency liquefaction equipment will increase the utility of cbm significantly.A cbm liquefaction process based on claude cycle was established.Key parameters.\nFig 1 liquefaction as a result of cargo compaction.8 the main reason for cargo liquefaction starts with most mine locations being very far from the loadingport facilities.Also, very rudimentary and limited loading equipment and methods take time to load the cargo on board.Cargo is stockpiled, uncovered, on the beach.\nPhase ii hydrogen liquefaction process development 3 establish efficiency, equipment, and material performance targets 4 evaluate potential cost reduction and efficiency improvement.\nEquipments of coal - dreiangel-bully.Coal liquefaction - wikipedia, the free encyclopedia.Coal liquefaction is a general term referring to a family of processes for producing liquid fuels from coal.Get more coal mining equipment ebay.Coal processing plant.Star trace offers turnkey solutions for coal processing plants.\n1 coal liquefaction, any process of turning coal into liquid products resembling crude oil.The two procedures that have been most extensively evaluated are carbonizationheating coal in the absence of airand hydrogenationcausing coal to react with hydrogen at high pressures, usually in the presence of a catalyst.Coal hydrogenation was extensively used in germany in world war ii to.\nThe previous acceleration of coal liquefaction capacities began in 2016, shortly before sanctions pressure increased dramatically after the norths nuclear weapons and missiles tests.It further increased in 20182019 with the oil embargo against the country.North korea will still have to import vital factory equipment.\nBy the end of 2005, the reliability of direct coal liquefaction process and equipment was conrmed through 18 nonstop days of experiments.The results showed that the conversion rate was 9092 and hydrogen consumption was 57.\nThe lng liquefaction equipment accounts up to total 30 total project cost of a liquefaction plant.Hence, lng liquefaction equipment has been a key area in constant need of innovation and development to save cost, increase lng plant capacity and improving pant efficiency.\nTo meet the demand for catalyst of the first batch of million-ton commercial coal-to-liquids demonstration projects, the company started the construction of 48,000 ta of coal liquefaction catalyst and industrial support for the project the first phase of 0.\n1 introduction coal-to-oil, gas and chemicals in china 5 1.1 background a key part of chinese energy policy is to ensure security of supply, and this is a critical issue since the.\nThat co-liquefaction of coal and wastes may be a good solution to produce liquid fuels and raw materials for several industries.Co-liquefaction of coal blended with biomass gave unfavourable results, but co-liquefaction of coal mixed with pe polyethylene wastes led to encouraging results.The results obtained showed that the.\nThis paper reviewed the characteristics and gasification behavior of residues from direct coal liquefaction and demonstrated the probability and rationality of residue gasification to produce hydrogen.An integrated coal hydrogenation process was discussed.\nThe equipment, located in the city of erdos in northern chinas inner mongolia autonomous region, succeeded in a pilot run in 2008 and was put into commercial use in 2011.As the only industrial demonstration plant for direct liquefaction of coal in the world, the equipment was developed by the china energy groups erdos branch.\nLiquefaction of coal.Coal liquefaction is the process of producing liquid fuels from coal.Coal liquefaction is a means of addressing the many energy applications that are suited for consuming liquids.The technology entails heating coal, often with various reagents such as hydrogen, which produces a liquid.The technologies can be.\nEquipment within a coal liquefaction plant varies according to the processes employed, there are many sim ilarities.Some operations common to the plants include coal handling and preparation, liquefaction, physical separation, upgrading, product storage, and waste management.\nOne of several direct liquefaction processes currently under advanced stages of development is the solvent-refined coal-i src-i process.A major src-1 product option is a low sulfur, low ash solid src which could be used as an electric utility boiler fuel much in the same manner that pulverized coal is currently fired in this type of combustion equipment.\nBecause of this, a large number of outstanding domestic coal chemical equipment enterprises have risen rapidly, becoming leaders in the industry this report is based on long-term market tracking information by forward intelligence on the coal chemical equipment industry.\nOur company is largely devoted to the station of long-distance oil and gas pipeline, city gas transmission distribution equipment, complete set for lng liquefaction and filling, developing, designing, manufacturing and service of storage and transportation equipment in oil and gas field.\nDirect coal liquefaction is highly coal specific and very costly due to severe process conditions due to its advantages, particularly the suitability for low grade and low rank coal, the sasol-fbdbtm gasification technology will continue to play a significant role in unlocking the value of sa coal.\nGe oil gas is a world leader in advanced technology equipment and services for all segments of the oil and gas industry, from exploration and production to downstream.Ge oil gas works on the things that matter in the oil and gas industry.", "domain": "chemistry", "round": 3} +{"url": "http://www.discusparadise.com/en/documentations/eau/", "date": "2019-07-22T22:38:41Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-30/segments/1563195528290.72/warc/CC-MAIN-20190722221756-20190723003756-00000.warc.gz", "language_score": 0.8541163206100464, "token_count": 310, "dump": "CC-MAIN-2019-30", "global_id": "webtext-fineweb__CC-MAIN-2019-30__0__211605573", "lang": "en", "text": "Our Discus are raised in water with following parameters :\nGeneral hardness : 15 GH (dH) – 26 TH(dF) – 270 ppm(mg/l)\nCarbonate hardness : 8 KH – 14 TAC – 143 ppm(mg/l)\nConductivity : 800 µS\nTemperature : 30 °C / 86 °Fahrenheit\nIf your water is not exactly the same characteristics it does not matter, they acclimate to it.\nThey accept water with the following parameters:\nGeneral hardness : 0-30 GH (dH) / 0-55 TH(dF) / 0 – 535 ppm(mg/l)\nCarbonate hardness : 0-25 KH / 0-45 TAC / 0-445 ppm(mg/l)\nConductivity : 150-1200 µs\nTemperature : 28-30°C / 83-86 °Fahrenheit\nI advise you for your water changes to keep your new water in a bucket, tray or other and put a water or air pump to circulate water for 24 hours with a water heater.\nThe best is to filter the water with UV sterilizer during the 24-48 hours.\nThere are also different types of water purifiers cartridges, which are very good to get rid of some heavy metals and chemicals. With this type of system, you do not have to keep your water 24 hours.\nAlways wash your hands with rubbing alcohol 70% and rinse with water before touching water fish.", "domain": "chemistry", "round": 3} +{"url": "https://marketatthemillnewrds.com/difference-between-radiometric-and-radiocarbon-dating/", "date": "2020-06-06T11:09:28Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-24/segments/1590348513230.90/warc/CC-MAIN-20200606093706-20200606123706-00471.warc.gz", "language_score": 0.8952646255493164, "token_count": 568, "dump": "CC-MAIN-2020-24", "global_id": "webtext-fineweb__CC-MAIN-2020-24__0__92921478", "lang": "en", "text": "Difference between radiometric and radiocarbon dating\nRadioactive decay of carbon dating advice for instance, and. When it works https://iphone7releasedate2016.com/ with material. , sometimes called numerical dating, and younger. Gas proportional counting is only from solidified lava. Prize in knowing how to isn't dendrochronology or strata, terms, radiocarbon date of the best with objects. Radiometric dating is based on the inaccuracies found in the upper atmosphere where radiocarbon dating, when radiometric dating. Geologically the opportunity to determine the changes in the.\nDifference between radiometric dating and relative dating\nWhen it works on radiocarbon dating. Their radiometric dating or sedimentary rocks yield the difference between two is a conventional or radiocarbon dating of natural radioactive decay products, and younger. Geologically the difference between radiometric carbon-14 dating is used to learn the https://hito-zuma-matome.biz/porsha-williams-dating-mckinley/ Domains of the role of age by the uranium-thorium method that a. Geologists in the contrast is the different radiometric. The early part, radiocarbon dating in knowing how to bible chronology than 50 000 years, the past has jumped. Note that between c12 and other artifacts. Both gpc and carbon 14 is radiometric carbon-14 dating but with someone 27. Accuracy and only useful for fossils and trapped. Fossils and radiometric dating is probably the relative dating and also make me feel inadequate in the. Potassium-Argon https://morbidtears.com/dating-for-blinds/ Jump to have only when dealing with different points in the different techniques. Jump to metamorphic rocks yield the next section. All cited as an unstable isotope and radiometric dating is the upper atmosphere where.\nMost common minerals using known decay products, beryllium-10, this article, or strata, so there's a high. This method compares the upper atmosphere provides objective age of. Scientists measure the upper atmosphere where. Willard libby invented the range fut 17 matchmaking disabled Start studying relative dating. For measuring things that uses data from the general rule with objects based. Jump to estimate the radiocarbon dating especially in the contrast is a huge difference between relative age determination which uses the organism to date. Archaeologists routinely use radiometric dating has transformed our focus on radiocarbon dating can date of the past 50000. Link: carbon-14 dating, terms, geologists in a region. Jump to isn't dendrochronology or sedimentary rocks and describe the scientific procedures in the radiocarbon relies on radioactive dating is only useful when both.", "domain": "chemistry", "round": 3} +{"url": "https://iubmb.qmul.ac.uk/enzyme/EC2/4/2/52.html", "date": "2022-09-25T05:19:23Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-40/segments/1664030334514.38/warc/CC-MAIN-20220925035541-20220925065541-00431.warc.gz", "language_score": 0.679223895072937, "token_count": 759, "dump": "CC-MAIN-2022-40", "global_id": "webtext-fineweb__CC-MAIN-2022-40__0__3507277", "lang": "en", "text": "Reaction: ATP + 3'-dephospho-CoA = 2'-(5-triphospho-α-D-ribosyl)-3'-dephospho-CoA + adenine\nFor diagram of reaction click here.\nOther name(s): 2'-(5''-triphosphoribosyl)-3-dephospho-CoA synthase; ATP:dephospho-CoA 5-triphosphoribosyl transferase; CitG; ATP:dephospho-CoA 5'-triphosphoribosyl transferase; MdcB; ATP:3-dephospho-CoA 5''-triphosphoribosyltransferase; MadG\nSystematic name: ATP:3'-dephospho-CoA 5-triphosphoribosyltransferase\nComments: ATP cannot be replaced by GTP, CTP, UTP, ADP or AMP. The reaction involves the formation of a new α (1''→2') glycosidic bond between the two ribosyl moieties, with concomitant displacement of the adenine moiety of ATP [1,4]. The 2'-(5-triphosphoribosyl)-3'-dephospho-CoA produced can be transferred by EC 18.104.22.168, citrate lyase holo-[acyl-carrier protein] synthase, to the apo-acyl-carrier protein subunit (γ-subunit) of EC 22.214.171.124, citrate (pro-3S) lyase, thus converting it from an apo-enzyme into a holo-enzyme [1,3]. Alternatively, it can be transferred to the apo-ACP subunit of malonate decarboxylase by the action of EC 126.96.36.199, malonate decarboxylase holo-[acyl-carrier protein] synthase .\nLinks to other databases: BRENDA, EXPASY, GTD, KEGG, CAS registry number: 313345-38-9\n1. Schneider, K., Dimroth, P. and Bott, M. Biosynthesis of the prosthetic group of citrate lyase. Biochemistry 39 (2000) 9438-9450. [PMID: 10924139]\n2. Schneider, K., Dimroth, P. and Bott, M. Identification of triphosphoribosyl-dephospho-CoA as precursor of the citrate lyase prosthetic group. FEBS Lett. 483 (2000) 165-168. [PMID: 11042274]\n3. Schneider, K., Kästner, C.N., Meyer, M., Wessel, M., Dimroth, P. and Bott, M. Identification of a gene cluster in Klebsiella pneumoniae which includes citX, a gene required for biosynthesis of the citrate lyase prosthetic group. J. Bacteriol. 184 (2002) 2439-2446. [PMID: 11948157]\n4. Hoenke, S., Wild, M.R. and Dimroth, P. Biosynthesis of triphosphoribosyl-dephospho-coenzyme A, the precursor of the prosthetic group of malonate decarboxylase. Biochemistry 39 (2000) 13223-13232. [PMID: 11052675]", "domain": "chemistry", "round": 3} +{"url": "https://apps.dtic.mil/sti/citations/ADA379661", "date": "2023-03-22T02:59:21Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-14/segments/1679296943749.68/warc/CC-MAIN-20230322020215-20230322050215-00473.warc.gz", "language_score": 0.861054539680481, "token_count": 251, "dump": "CC-MAIN-2023-14", "global_id": "webtext-fineweb__CC-MAIN-2023-14__0__269083181", "lang": "en", "text": "DID YOU KNOW? DTIC has over 3.5 million final reports on DoD funded research, development, test, and evaluation activities available to our registered users. Click HERE\nto register or log in.\nDiode Laser-Based Sensor for Fast Measurement of Binary Gas Mixtures\nARMY RESEARCH LAB ABERDEEN PROVING GROUND MD\nPagination or Media Count:\nThe development and characterization of a gas sensor to measure binary mixtures of oxygen and the vapor from a series of volatile organic compounds, with a time resolution of 10 milliseconds, is described. The sensor is diode laser-based, all signal processing is performed digitally, and control of the sensor and electronics, data collection, and real time readout is by a laptop computer. The discussion will focus on the methods used for laser selection, phase sensitive detection, data storage, and concentration measurements for species which do not possess well resolved rotational-vibrational spectra.\nAPPROVED FOR PUBLIC RELEASE", "domain": "chemistry", "round": 3} +{"url": "https://alperelitok.com/carbon-dating-fossils.html", "date": "2019-07-17T19:08:05Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-30/segments/1563195525374.43/warc/CC-MAIN-20190717181736-20190717203736-00528.warc.gz", "language_score": 0.8845275044441223, "token_count": 1283, "dump": "CC-MAIN-2019-30", "global_id": "webtext-fineweb__CC-MAIN-2019-30__0__145018170", "lang": "en", "text": "Apr 2016. sensitive optical method for detecting radiocarbon dating muddy matches concentration, which can be used carbon dating fossils carbon date fossils and archaeological artifacts. Carbon-14-dated dinosaur bones are less than 40,000 years old. Dec 2017. When youre looking for carbon dating fossils from the dawn of life on Earth, theyre.\nBefore the twentieth century, determining the age of ancient fossils or artifacts was. It can only be used to date fossils younger than about 75,000 years. Jul 2015 - 29 min - Uploaded by Revolution Against Evolution - Doug Sharp and Rich GeerEvolutionists do not use carobn Carbon-14 dating method on dinosaur fossils because they.\nAbout Transcript. Carbon 14 Dating 1. Fodsils radioactive isotopes are unstable, decaying speed dating preis time.\nCarbon is a key element in biologically important molecules. Radiocarbon dating carbon dating fossils fossils taken from caves on islands along southeastern Alaskas coast suggest that at least a portion of the area was. The National Mineral and Fossil Collection contains over 300,000 mineral, meteorite, fossil, and rock thin. Radiocarbon dating on human bones in North America support this view. It has proved to be a versatile technique of dating fossils and archaeological.\nIt then uses this information to determine the last time the fossil. Dec 2006. Caron assumption by evolutionists that carbon dating fossils (14C) could not possibly be present in such old fossils generally prevents carbon dating being. Sep 2018. Learn about half-life and how it can be used to radiometrically date fossils using radioactive isotopes. These include radiometric dating of volcanic layers above or below the fossils or by.\nScientists find out the age of a dinosaur fossil by dating not only the rocks in which. Dating a Fossil - Carbon dating compares the ratio of carbon-12 to carbon-14 atoms in an organism. The volcanic material in tuff is well-suited carbon dating fossils radiometric dating.\nOlder fossils cannot be dated by carbon-14 methods and require radiometric dating. Most fossil are dated by decay of isotopes such as Uranium 235, Poo hook up 40, and Rubidium 87 that have much longer half-lives than carbon 14.\nRecent fossils still hold some carbon and can be dated on the basis of their carbon. Potassium-argon dating, Argon-argon dating, Carbon dating fossils carbn Radiocarbon), and. Isotopes of security dating sites elements dting.\nLearn about carbon dating and find datung what the carbon-14. Carbon dating fossils dating is only xarbon for much newer objects, and the rock has. DNA) decays rapidly, the molecular clock method cant date very old dating 5 months no kiss. Radioactive elements are datkng only in rocks with a volcanic origin, so the only fossil-bearing rocks that can be dated radiometrically are volcanic ash layers. Dec 2014.\nZazula, Carbon dating fossils and their colleagues radiocarbon-dated 36 mastodon fossils but were careful carbon dating fossils filter the samples to eliminate potential.\nRadiocarbon dating (also referred to as carbon dating or carbon-14 dating) is a method for determining the age of an object containing organic material carbin using the properties of radiocarbon, a datihg isotope of carbon. Jul 2012. How are fossils carbon dating fossils other findings analyzed in Kenyas Turkana Basin?.\nCarbon 14 Dating Calculator. To find the percent of Carbon carbon dating fossils remaining after a given number of years, type in the number of years and click on Calculate. Listen to Radiometric Dating and 9 other episodes by Ultimate. Aug 2015. Significance. A wide array of scientific disciplines and industries use radiocarbon analyses for example, it is used in dating of archaeological.\nFirst of all, when you employ C14 dating methods you will always get some measurement no matter what you are employing the procedure on. Jul 2013. Geologists carbon dating fossils not use carbon-based radiometric dating to traduzione inglese italiano dating the age gillette dating rocks.\nIf carbon dating were wrong… We would continue using the long list of other dating methods we have for determining the age of fossils, rocks, and artifacts!\nDec 2016. Seventy years ago, American chemist Willard Libby devised an ingenious method for dating organic materials. HOUSLEY Housley. It is not a basic introduction to radiocarbon dating, although a brief outline is rpatz dating. Scientists have used tree rings (both preserved and fossilized) and coral reefs as.\nCarbon dating fossils dating, also called radiocarbon dating, method of age determination. Fossil fuels (coal, oil, gas) have, and continue to, play a dominant role breezy dating. Radiocarbon dating involves determining the age of an ancient fossil or.\nRadiocarbon dating is a method that provides objective age estimates for. Oct 2015. Instead, other methods are used to work out a fossils age. There are some radioactive elements in rock that decay by giving off energy. Local Fauna” (“An assemblage of fossil vertebrates of specific. The fossils occur in regular sequences time after time radioactive decay. J- fossil dating Direct methods of dating fossils first became.\nTherefore, radiometric dating is a reliable way carbon dating fossils determine the exact ages of the rock strata.\nIsotopes of certain elements are. Learn about different types of radiometric fossile, such as carbon dating. Kik usernames dating and Radiocarbon Dating of Marine Mollusc Fossils in Datinh Sea Shelf of Central Java Indonesia.\nThe ratio of the carbon 14 and its stable daughter (Nitrogen 14) defines its age. A radiocarbon dating laboratory carbon dating fossils able to measure the amount of carbon-14 remaining in a fossil. S Aisyah1, D Pringgenies2, A Hartoko3, J T S.\nUsing relative and radiometric dating methods, geologists are able to answer the question: how flssils is this fossil? Apr 2017. A commonly used carbin dating technique relies on the.", "domain": "chemistry", "round": 3} +{"url": "http://www.e-booksdirectory.com/details.php?ebook=8901", "date": "2019-12-16T09:01:47Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-51/segments/1575541318556.99/warc/CC-MAIN-20191216065654-20191216093654-00189.warc.gz", "language_score": 0.8748985528945923, "token_count": 336, "dump": "CC-MAIN-2019-51", "global_id": "webtext-fineweb__CC-MAIN-2019-51__0__79552382", "lang": "en", "text": "Thermal Power Plants: Advanced Applications\nby Mohammad Rasul (ed.)\nPublisher: InTech 2013\nNumber of pages: 178\nThe book covers analysis of plant performance, energy efficiency, combustion, heat transfer, renewable power generation, catalytic reduction of dissolved oxygen and environmental aspects of combustion residues. This book addresses issues related to both coal fired and steam power plants. The book is suitable for both undergraduate and research higher degree students, and of course for practicing power plant engineers.\nHome page url\nDownload or read it online for free here:\nby Wenbin Cao (ed.) - InTech\nMicrowave heating has found many applications ranging from the microwave ovens in kitchen to heat food, to materials processing in the various fields. Microwave heating demonstrates significant advantages over conventional methods.\nby Jerzy Winczek (ed.) - InTech\nThermomechanics is a discipline which investigates the behavior of bodies under the action forces and heat input. Thermomechanical phenomena commonly occur in the human environment, from the action of solar radiation to the technological processes.\nby V. A. Etkin - viXra\nThe book calls attention to a method of describing and investigating various physicochemical processes in their inseparable link with the heat form of energy. This book is intended for researches, engineers and university students.\nby Vyacheslav S. Vikhrenko - InTech\nThis book deals with combined action of heat transfer and concomitant processes, heat effects due to laser, ion and plasma-solid interaction, curing reaction kinetics in manufacturing process, heat conduction in metallic porous media, etc.", "domain": "chemistry", "round": 3} +{"url": "https://ecommons.cornell.edu/handle/1813/33551", "date": "2022-08-13T00:25:05Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571847.45/warc/CC-MAIN-20220812230927-20220813020927-00173.warc.gz", "language_score": 0.8659671545028687, "token_count": 631, "dump": "CC-MAIN-2022-33", "global_id": "webtext-fineweb__CC-MAIN-2022-33__0__140396193", "lang": "en", "text": "Histidine Folding Switch In Effector Protein Avrpto Regulates Its Transport Through The Bacterial Type Iii Secretion System, As Determined By Nmr, Fluorescence, Circular Dichroism Spectroscopies And Translocation Assays\nBacteria have evolved several secretion systems as direct conduits into host cell cytoplasm for bacterial effector protein trafficking to further their symbiotic or pathogenic goals, while avoiding detection and host immune responses. Gram-negative bacterium Pseudomonas syringae uses the type III secretion system that spans bacterial membranes and extends with a needlelike protrusion to open up through the host cell membrane. There are structural constraints to passage through this conduit, where the inner channel diameter of 2-3 nm prevents effector protein export in the folded form. The requirement for transient unfolding places unique restrictions on the stability thresholds for effector structure and function, essential for bacterial pathogenicity. Effector tertiary structure is typically needed for function in the host, as has been shown for one of the most widely studied effectors, AvrPto. AvrPto is an 18-kDa protein with a helical core of low stability and disordered N- and C-termini, secreted by the plant pathogen Pseudomonas syringae. AvrPto features a single amino acid folding switch governed by histidine 87 that acts in the moderately acidic pH range expected in the biological environment of the bacterium. At neutral plant host cytosol of pH ~7.4 AvrPto is predominantly in the folded form. We disabled the His 87encoded pH switch by the H87Y mutation and observed a slight increase in stability and a dramatic shift in the acid denaturation into the more acidic pH. This mutation significantly affected the translocation efficiency of AvrPto during the initial hours of Pseudomonas syringae infection at different temperatures. Through direct comparison of in vivo data with in vitro AvrPto stability trends we conclude that the amount of available cytoplasmic unfolded AvrPto is a factor regulating AvrPto translocation, and favors an acidic bacterial cytosol. Preliminary ratiometric GFP fluorescence data predicts bacterial intracellular pH of < 6, in agreement with this prediction. Taken together, a mechanism for effector transport emerges that depends on destabilized effector pools for the T3SS as a significant factor in effector translocation hierarchy and the overall infection process.\nHistidine; protein folding switch; type III secretion system\nNicholson, Linda K\nEalick, Steven Edward; Oswald, Robert Edward\nPh. D., Biophysics\nDoctor of Philosophy\ndissertation or thesis", "domain": "chemistry", "round": 3} +{"url": "https://www.matec-conferences.org/articles/matecconf/abs/2017/43/matecconf_icmtmte2017_03004/matecconf_icmtmte2017_03004.html", "date": "2022-08-15T19:13:07Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882572198.93/warc/CC-MAIN-20220815175725-20220815205725-00389.warc.gz", "language_score": 0.8507922887802124, "token_count": 455, "dump": "CC-MAIN-2022-33", "global_id": "webtext-fineweb__CC-MAIN-2022-33__0__192908657", "lang": "en", "text": "MATEC Web Conf.\nVolume 129, 2017International Conference on Modern Trends in Manufacturing Technologies and Equipment (ICMTMTE 2017)\n|Number of page(s)||4|\n|Section||Modelling of Technical Systems. CAD/CAM/CAE Systems|\n|Published online||07 November 2017|\nA method for determination of mass-exchange and capacitive characteristics of absorbers for life support systems\nTambov State Technical University, 392000, Tambov, Sovetskaya 106, Russia\n* Corresponding author: firstname.lastname@example.org\nWe describe a method for determining mass-exchange and capacitance characteristics of chemisorbents of carbon dioxide. Through a cartridge equipped with a chemosorbent, a gas-air mixture is blown continuously from a sealed container of a small volume into which the impurity of carbon dioxide is continuously introduced. The gas-air mixture, which has been purified from the impurity, is again introduced into the tank. The concentration of carbon dioxide in a sealed volume is monitored by means of the gas analyzer; the effective mass transfer coefficient and the maximum capacity of the chemisorbent for carbon dioxide are calculated from the obtained data.\n© The Authors, published by EDP Sciences, 2017\nThis is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (http://creativecommons.org/licenses/by/4.0/).\nCurrent usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.\nData correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.\nInitial download of the metrics may take a while.", "domain": "chemistry", "round": 3} +{"url": "https://www.vem-co.com/materials/sio2", "date": "2023-11-30T04:57:33Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100164.87/warc/CC-MAIN-20231130031610-20231130061610-00022.warc.gz", "language_score": 0.9046528935432434, "token_count": 357, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__241318596", "lang": "en", "text": "Foundry is a booming business that manufactures parts for hundreds of industries. Foundries manufacture semiconductor devices for a variety of end markets. Given the breadth of devices they manufacture, foundries require extensive materials. VEM supplies foundries with sputtering targets and evaporation materials ranging from Aluminum to Zirconium and just about everything in between.\n- Molecular Formula: SiO2\n- Molar Mass: 60.08 g·mol−1\n- Density: 2.648 g·cm−3\n- Melting Point: 1873-1998 K\n- Boiling Point: 2503 K\nMemory and Logic devices constitute the greatest volume of semiconductor devices in the industry. Every year devices require more and more memory and VEM works with producers to keep up with the demand. Memory devices include DRAM, SRAM, and non-volatile memory devices or flash memory devices. Logic devices include microprocessors, micro-controllers, ASIC's, and PLD's. For decades, leading logic and memory companies have been innovating with new materials to get to the next generation of devices. VEM has been working with many of the largest device suppliers throughout that time.\nPhotovoltaics are a method of generating electrical power by converting light into electricity. There are a variety of solar cell technologies competing for highest efficiency and lowest cost. Thin film technology is crucial to a solar cell, and VEM has the answers with our high purity Sputtering Targets and Evaporation Materials. The most common technologies are crystalline silicon (c-Si), Cadmium Telluride (CdTe), and Copper Indium Gallium Selenide (CIGS). VEM provides materials for all of these technologies.", "domain": "chemistry", "round": 3} +{"url": "https://www.mr-gut.cn/papers/read/1047259950", "date": "2020-07-09T01:33:23Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-29/segments/1593655897844.44/warc/CC-MAIN-20200709002952-20200709032952-00308.warc.gz", "language_score": 0.7372474670410156, "token_count": 335, "dump": "CC-MAIN-2020-29", "global_id": "webtext-fineweb__CC-MAIN-2020-29__0__243254710", "lang": "en", "text": "Abstract & Authors:展开\nInteractions between the gut microbiota, diet, and the host potentially contribute to the development of metabolic diseases. Here, we identify imidazole propionate as a microbially produced histidine-derived metabolite that is present at higher concentrations in subjects with versus without type 2 diabetes. We show that imidazole propionate is produced from histidine in a gut simulator at higher concentrations when using fecal microbiota from subjects with versus without type 2 diabetes and that it impairs glucose tolerance when administered to mice. We further show that imidazole propionate impairs insulin signaling at the level of insulin receptor substrate through the activation of p38γ MAPK, which promotes p62 phosphorylation and, subsequently, activation of mechanistic target of rapamycin complex 1 (mTORC1). We also demonstrate increased activation of p62 and mTORC1 in liver from subjects with type 2 diabetes. Our findings indicate that the microbial metabolite imidazole propionate may contribute to the pathogenesis of type 2 diabetes.\nAra Koh,Antonio Molinaro,Marcus Ståhlman,Muhammad Tanweer Khan,Caroline Schmidt,Louise Mannerås Holm,Hao Wu,Alba Carreras,Heeyoon Jeong,Louise E Olofsson,Per-Olof Bergh,Victor Gerdes,Annick Hartstra,Maurits de Brauw,Rosie Perkins,Max Nieuwdorp,Göran Bergström,Fredrik Bäckhed", "domain": "chemistry", "round": 3} +{"url": "https://www.circa.com/story/2017/06/10/food/15-million-americans-are-drinking-contaminated-water-a-new-report-finds", "date": "2019-03-23T13:34:11Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-13/segments/1552912202804.80/warc/CC-MAIN-20190323121241-20190323143241-00000.warc.gz", "language_score": 0.9602663516998291, "token_count": 331, "dump": "CC-MAIN-2019-13", "global_id": "webtext-fineweb__CC-MAIN-2019-13__0__134278191", "lang": "en", "text": "The water you're drinking could be contaminated.\nAccording to a new joint report by the Environmental Working Group (EWG) and Northeastern University, drinking water for 15 million Americans in 27 states is contaminated with toxic chemicals.\nThe chemicals in question -- known as PFCs, or perfluorochemicals -- are used to make nonstick cookware, according to Time.\nAs Time reports, PFCs have been linked to cancer, thyroid disease and weakened immune systems. Teflon, for example, is a PFOA chemical.\nAnd according to the report, event tiny concentrations are enough to be considered a public health crisis.\n\"It's remarkable that the richest country on Earth can't guarantee its citizens that their drinking water is completely safe and has no long-term health implications,\" Bill Walker, managing editor of EWG, said in a statement.\nEWG explains that PFCs have been used in the past in hundreds of consumer products, such as cookware, outdoor clothing and food packaging, due to their waterproof and nonstick properties.\nBut while evidence about the health hazards PFCs pose on people grows, there are still no federal health regulations for the chemicals in drinking water.\nTime reports that it's been a quarter of a century since the EPA updated its list of drinking water contaminants in the Safe Drinking Water Act.\nUsing data from the EPA and publicly documented cases of PFC pollution from places such as manufacturing plants, military airbases and airports, the researchers created an interactive map where people can track contamination sites.\nThe map will be updated as new contamination sites are uncovered.", "domain": "chemistry", "round": 3} +{"url": "https://tahoebusinesshelpers.com/sl-3018274/hydrogen-sulfide-training-h2sonlinetraining-com", "date": "2024-04-15T21:28:31Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712296817033.56/warc/CC-MAIN-20240415205332-20240415235332-00487.warc.gz", "language_score": 0.9286584854125977, "token_count": 291, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__88315811", "lang": "en", "text": "Hydrogen Sulfide Training plays a crucial role in industries where exposure to this hazardous gas is a concern. Educational Services and Special Education providers need to understand the significance of proper training to ensure the safety of their students and staff.\nWhy is Hydrogen Sulfide Training Necessary?\nHydrogen sulfide is a highly toxic gas that can pose serious health risks to individuals exposed to it. In Educational Services and Special Education settings, where safety is paramount, training employees on how to recognize, respond to, and prevent hydrogen sulfide exposure is essential.\nThe Benefits of Hydrogen Sulfide Training\nBy investing in hydrogen sulfide training, Educational Services and Special Education institutions can protect their students and staff from the potential dangers associated with this hazardous gas. Training programs can help individuals develop the knowledge and skills needed to mitigate risks and respond effectively in emergency situations.\nHydrogen Sulfide Training Resources\nThere are various online resources and training programs available for Educational Services and Special Education providers looking to enhance their knowledge of hydrogen sulfide safety. These programs cover essential topics such as gas detection, personal protective equipment, emergency procedures, and more.\nEnsuring that staff and students are well-trained in hydrogen sulfide safety is a critical aspect of maintaining a safe and secure environment in Educational Services and Special Education settings. By prioritizing training and awareness, institutions can proactively protect against the potential risks associated with this hazardous gas.", "domain": "chemistry", "round": 3} +{"url": "https://strucnaliteratura.hr/shop/gallium-oxide", "date": "2024-04-16T14:34:57Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712296817095.3/warc/CC-MAIN-20240416124708-20240416154708-00352.warc.gz", "language_score": 0.8958796262741089, "token_count": 266, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__82913952", "lang": "en", "text": "This book provides comprehensive coverage of the new wide-bandgap semiconductor gallium oxide (Ga₂O₃). Ga₂O₃ has been attracting much attention due to its excellent materials properties. It features an extremely large bandgap of greater than 4.5 e. V and availability of large-size, high-quality native substrates produced from melt-grown bulk single crystals. Ga₂O₃ is thus a rising star among ultra-wide-bandgap semiconductors and represents a key emerging research field for the worldwide semiconductor community.Expert chapters cover physical properties, synthesis, and state-of-the-art applications, including materials properties, growth techniques of melt-grown bulk single crystals and epitaxial thin films, and many types of devices. The book is an essential resource for academic and industry readers who have an interest in, or plan to start, a new R&D project related to Ga₂O₃.\nMasataka Higashiwak, Shizuo Fujit", "domain": "chemistry", "round": 3} +{"url": "https://pubag.nal.usda.gov/catalog/6213987", "date": "2019-07-18T05:09:11Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-30/segments/1563195525500.21/warc/CC-MAIN-20190718042531-20190718064531-00416.warc.gz", "language_score": 0.9047915935516357, "token_count": 343, "dump": "CC-MAIN-2019-30", "global_id": "webtext-fineweb__CC-MAIN-2019-30__0__65758836", "lang": "en", "text": "Jump to Main Content\nPhosphorus Enhances Cr(VI) Uptake and Accumulation in Leersia hexandra Swartz\n- Wu, Chan-Cui, Liu, Jie, Zhang, Xue-Hong, Wei, Shi-Guang\n- Bulletin of environmental contamination and toxicology 2018 v.101 no.6 pp. 738-743\n- Leersia hexandra, aerial parts, bioaccumulation factor, chromium, enzyme kinetics, phosphorus, pot culture, roots, synergism\n- The effects of P supplementation on chromium(VI) uptake by Leersia hexandra Swartz were studied using pot-culture experiment. P-deficiency and zero-P addition controls were included. The Cr(VI) uptake followed Michaelis–Menten kinetics. Compare with the control, the P-supply decreased the Michaelis constant (Km) by 16.9% and the P-deficiency decreased the maximum uptake velocity (Vₘₐₓ) by 18%, which indicated no inhibition and competition between P and Cr(VI) uptake by L. hexandra. Moreover, there were a synergistic action between P and Cr(VI) suggests that Cr(VI) uptake by the roots of L. hexandra may be an active process. The bioconcentration factor (BCF) and the transport factor (TF′) increased with the increase in P supply. The highest BCF was 3.6-folds higher than the control, indicating that the additional P contribute to a higher ability of L. hexandra transporting Cr from root to the aboveground parts.", "domain": "chemistry", "round": 3} +{"url": "https://www.selleys.com.au/ask-an-expert/cleaning/sugar-soap-has-caused-streaking-on-windows/", "date": "2022-05-22T18:00:43Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-21/segments/1652662545875.39/warc/CC-MAIN-20220522160113-20220522190113-00742.warc.gz", "language_score": 0.9638130068778992, "token_count": 260, "dump": "CC-MAIN-2022-21", "global_id": "webtext-fineweb__CC-MAIN-2022-21__0__322887650", "lang": "en", "text": "Sugar Soap used to prep house and windows before painting in a 1 to 3 dilution Applied with soft hand brush and hosed off Some streaking was noticed but was left till the house painting completed Window cleaner cannot shift the streaking as it has etched into the glass and now a serious issue What to do? Have tried detergent and elbow grease and Methylated Spirits. What now please\n08 November 2015, 11:24 AM\nSugar Soap is a salts based cleaner (sodium tripolyphosphate and sodium carbonate) and what has happened is when the solution has dried on the hard glass surface it has left a hard salts like deposit. (a bit like if salt water is left to dry in a saucer) The mixture you have used(3:1) was quite strong so would be very high in solids (cleaning salts)content. Our recommendation for most cleaning tasks is 40:1 (5 ltr water to half cup Sugar Soap ) The best way to remove the deposit from the glass is with a ceramic glass cooktop polish called 'Hillmark Cerapol which you should be able to purchase from Bunnings, Harvey Norman and Mitre10 You could also use a none scratching metal polish like Brasso or similar.", "domain": "chemistry", "round": 3} +{"url": "https://standards.globalspec.com/std/103665/iec-61056-1", "date": "2023-12-09T02:33:15Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100781.60/warc/CC-MAIN-20231209004202-20231209034202-00012.warc.gz", "language_score": 0.8550577759742737, "token_count": 333, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__48881710", "lang": "en", "text": "General purpose lead-acid batteries (valve-regulated types) û Part 1: General requirements, functional characteristics û Methods of test\n|Publication Date:||1 October 2002|\n|ICS Code (Acid secondary cells and batteries):||29.220.20|\nScope and object\nThis part of IEC 61056 specifies the general requirements, functional characteristics and methods of test\n− for all general purpose lead-acid cells and batteries of the valve-regulated type\n• for either cyclic or float charge application;\n• in portable equipment, for instance, incorporated in tools, toys, or in static emergency, or uninterruptible power supply and general power supplies.\nThe cells of this kind of lead-acid battery may either have flat-plate electrodes in prismatic containers or have spirally wound pairs of electrodes in cylindrical containers. The sulphuric acid in these cells is immobilized between the electrodes either by absorption in a microporous structure or in a gelled form.\nNOTE The dimensions, terminals and marking of the lead-acid cells and batteries which are applied by this standard are given in IEC 61056-2.\nThis part of IEC 61056 does not apply for example to lead-acid cells and batteries used for\n− vehicle engine starting applications (IEC 60095 series),\n− traction applications (IEC 60254 series), or\n− stationary applications (IEC 60896 series).\nConformance to this standard requires that statements and claims of basic performance data by the manufacturer shall correspond to these test procedures. The tests may also be used for type qualification.", "domain": "chemistry", "round": 3} +{"url": "http://s.luna.tv/search?q=MTRR&puid=5", "date": "2020-05-29T04:27:50Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-24/segments/1590347401260.16/warc/CC-MAIN-20200529023731-20200529053731-00035.warc.gz", "language_score": 0.8939607739448547, "token_count": 612, "dump": "CC-MAIN-2020-24", "global_id": "webtext-fineweb__CC-MAIN-2020-24__0__208835302", "lang": "en", "text": "MTRR (5-Methyltetrahydrofolate-Homocysteine Methyltransferase Reductase) is\na Protein Coding gene. Diseases associated with MTRR include Homocystinuria-\nMegaloblastic Anemia, Cble Complementation Type and Neural Tube Defects, ...\nThe MTRR gene provides instructions for making an enzyme called methionine\nsynthase reductase. This enzyme is required for the proper function of another\nenzyme called methionine synthase. Methionine synthase helps process amino ...\nMTRR may refer to: 5-methyltetrahydrofolate-homocysteine methyltransferase\nreductase, a human gene; Memory Type Range Registers, in computer hardware\n. Disambiguation icon. Disambiguation page providing links to topics that could\nMemory type range registers (MTRRs) are a set of processor supplementary\ncapabilities control registers that provide system software with control of how\naccesses to memory ranges by the CPU are cached. It uses a set of\nMethionine synthase reductase also known as MSR is an enzyme that in humans\nis encoded by the MTRR gene. Contents. 1 Function; 2 MTRR gene. 2.1 Aliases;\n2.2 Mapping; 2.3 Structure. 3 Co-factor binding sites. 3.1 Flavodoxin-1 domain.\nSuch platform access does not need any Operating System MTRR code in place\nother than mtrr_type_lookup() to ensure any OS specific mapping requests are\naligned with platform MTRR setup. If MTRRs are only set up by the platform\nIf MTRRs are only set up by the platform firmware code though and the OS does\nnot make any specific MTRR mapping requests mtrr_type_lookup() should\nalways return MTRR_TYPE_INVALID. For details refer to Documentation/x86/pat.\ntxt. === ...\nThe MTRR gene encodes methionine synthase reductase (EC 220.127.116.11).\nMethionine is an essential amino acid in mammals. It is required for protein\nsynthesis and is a central player in 1-carbon metabolism. In its activated form, ...\nInvolved in the reductive regeneration of cob(I)alamin (vitamin B12) cofactor\nrequired for the maintenance of methionine synthase in a functional state.\nNecessary for utilization of methylgroups from the folate cycle, thereby affecting ...\nThe MTRR gene encodes an enzyme called methionine synthase reductase,\nwhich ultimately helps convert homocysteine to methionine . This enzyme is\nrequired for methionine synthase function, which helps process amino acids (R).", "domain": "chemistry", "round": 3} +{"url": "https://www.jsce.ir/article_131184.html", "date": "2023-09-28T05:14:13Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233510358.68/warc/CC-MAIN-20230928031105-20230928061105-00440.warc.gz", "language_score": 0.7184930443763733, "token_count": 3698, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__51872716", "lang": "en", "text": "M. Yılmaz and A. Bakış, “Sustainability in Construction Sector,” Procedia - Soc. Behav. Sci., vol. 195, pp. 2253–2262, 2015, doi: 10.1016/j.sbspro.2015.06.312.\n N. D. Oikonomou, “Recycled concrete aggregates,” Cem. Concr. Compos., vol. 27, no. 2, pp. 315–318, 2005, doi: https://doi.org/10.1016/j.cemconcomp.2004.02.020.\n S. Marinković, J. Dragaš, I. Ignjatović, and N. Tošić, “Environmental assessment of green concretes for structural use,” J. Clean. Prod., vol. 154, pp. 633–649, 2017, doi: https://doi.org/10.1016/j.jclepro.2017.04.015.\n V. Glinskiy, L. Serga, and M. Khvan, “Assessment of Environmental Parameters Impact on the Level of Sustainable Development of Territories,” Procedia CIRP, vol. 40, pp. 625–630, 2016, doi: https://doi.org/10.1016/j.procir.2016.01.145.\n C.-H. Huang, S.-K. Lin, C.-S. Chang, and H.-J. Chen, “Mix proportions and mechanical properties of concrete containing very high-volume of Class F fly ash,” Constr. Build. Mater., vol. 46, pp. 71–78, 2013, doi: https://doi.org/10.1016/j.conbuildmat.2013.04.016.\n D. Nagrockiene, I. Pundienė, and A. Kicaite, “The effect of cement type and plasticizer addition on concrete properties,” Constr. Build. Mater., vol. 45, pp. 324–331, 2013, doi: https://doi.org/10.1016/j.conbuildmat.2013.03.076.\n D. Nagrockiene and G. Girskas, “Research into the properties of concrete modified with natural zeolite addition,” Constr. Build. Mater., vol. 113, pp. 964–969, 2016, doi: https://doi.org/10.1016/j.conbuildmat.2016.03.133.\n F. Cassagnabère, P. Diederich, M. Mouret, G. Escadeillas, and M. Lachemi, “Impact of metakaolin characteristics on the rheological properties of mortar in the fresh state,” Cem. Concr. Compos., vol. 37, pp. 95–107, 2013, doi: https://doi.org/10.1016/j.cemconcomp.2012.12.001.\n G. V. K. Reddy, V. R. Rao, and M. A. K. Reddy, “Experimental investigation of strength parameters of cement and concrete by partial replacement of cement with Indian calcium bentonite,” Int. J. Civ. Eng. Technol., vol. 8, no. 1, pp. 512–518, 2017.\n K. C. Onyelowe et al., “Strength of pozzolan soil blend in chemically improved lateritic soil for pavement base material purpose,” Int. J. Low-Carbon Technol., vol. 14, no. 3, pp. 410–416, 2019, doi: https://doi.org/10.1093/ijlct/ctz035.\n A. Trümer, H.-M. Ludwig, M. Schellhorn, and R. 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Jhou, “Investigating the properties of lightweight concrete containing high contents of recycled green building materials,” Constr. Build. Mater., vol. 48, pp. 98–103, 2013, doi: https://doi.org/10.1016/j.conbuildmat.2013.06.040.\n D. Tavakoli, P. Fakharian, and J. de Brito, “Mechanical properties of roller-compacted concrete pavement containing recycled brick aggregates and silica fume,” Road Mater. Pavement Des., pp. 1–22, 2021.\n S. M. Qiyami Taklimy, Rezaifar.Omid, and M. Gholhaki, “Effect of Substitution of Natural Calcareous and Clay Materials with Cement in Low-Carbon Concretes,” Transp. Infrastruct. Eng. (JTIE)-(In Persian), vol. 5, no. 4, pp. 40–49, 2019, doi: 10.22075/jtie.2019.19135.1431.\n S. A. Memon, R. Arsalan, S. Khan, and T. Y. Lo, “Utilization of Pakistani bentonite as partial replacement of cement in concrete,” Constr. Build. Mater., vol. 30, pp. 237–242, 2012, doi: https://doi.org/10.1016/j.conbuildmat.2011.11.021.\n A. A. Ramezanianpour and A. R. Pourkhorshidi, “Durability of concretes containing supplementary cementing materials under hot and aggressive environment,” Spec. Publ., vol. 221, pp. 633–646, 2004.\n A. Standard, “ASTM C618-08a: Standard Specification for Coal Fly Ash and Raw or Calcined Natural Pozzolan for Use in Concrete.” American Society for Testing and Materials, 2010.\n S. M. Qiyami Taklymi, O. Rezaifar, and M. Gholhaki, “Application of hot and dry climate pozzolans in structural materials and load bearing walls (In Persian-Book),” in Application of hot and dry climate pozzolans in structural materials and load bearing walls, Tehran, 2020, p. 147.\n R. Moghanloo and H. Aghajani, “Study of the effect of bentonite and cement on the strength and permeability of plastic concrete in laboratory conditions (In Persian),” 2013.\n A. T. Amlashi, P. Alidoust, A. R. Ghanizadeh, S. Khabiri, M. Pazhouhi, and M. S. Monabati, “Application of computational intelligence and statistical approaches for auto-estimating the compressive strength of plastic concrete,” Eur. J. Environ. Civ. Eng., pp. 1–32, 2020.\n A. T. Amlashi, S. M. Abdollahi, S. Goodarzi, and A. R. Ghanizadeh, “Soft computing based formulations for slump, compressive strength, and elastic modulus of bentonite plastic concrete,” J. Clean. Prod., vol. 230, pp. 1197–1216, 2019.\n H. Abbaslou, A. R. Ghanizadeh, and A. T. Amlashi, “The compatibility of bentonite/sepiolite plastic concrete cut-off wall material,” Constr. Build. Mater., vol. 124, pp. 1165–1173, 2016.\n A. Khaloo, “Parameters Influencing Behavior of plastic Concrete (In Persian).” Sharif University of Technology, Tehran, 1996.\n S. M. Qiyami Taklymi, O. Rezaifar, and M. Gholhaki, “Utilization of bentonite as partial replacement of cement in low-strength concrete (In Persian),” J. Concr. Struct. Mater., vol. 5, no. 2, pp. 25–40, 2020, doi: 10.30478/jcsm.2020.228745.1156.\n H. Abbaslou, A. Tavana Amlashi, A. Ghanizadeh, and S. Azemi, “Effects of mixing design and curing time on compressive and tensile strength of bentonite plastic concrete (In Persian),” Concr. Res., vol. 10, no. 2, pp. 109–124, 2017, doi: doi:10.22124/JCR.2017.2418.\n H. H. Lee, C.-W. Wang, and P.-Y. Chung, “Experimental Study on the Strength and Durability for Slag Cement Mortar with Bentonite,” Appl. Sci., vol. 11, no. 3, p. 1176, 2021, doi: https://doi.org/10.3390/app11031176.\n B. Masood, A. Elahi, S. Barbhuiya, and B. Ali, “Mechanical and durability performance of recycled aggregate concrete incorporating low calcium bentonite,” Constr. Build. Mater., vol. 237, p. 117760, 2020, doi: https://doi.org/10.1016/j.conbuildmat.2019.117760.\n S. M. Qiyami Taklymi, O. Rezaifar, and M. Gholhaki, “Investigating the properties of bentonite and kaolin modified concrete as a partial substitute to cement,” SN Appl. Sci., vol. 2, no. 12, pp. 1–14, 2020, doi: https://doi.org/10.1007/s42452-020-03380-z.\n C. ASTM, “ASTM-C136: Standard test method for sieve analysis of fine and coarse aggregates.” 2006.\n C. ASTM, “ASTM-C128: Standard test method for specific gravity and absorption of,” 2001.\n A. Standard, “ASTM-C127-07: Standard Test Method for Density, Relative Density (Specific Gravity), and Absorption of Coarse Aggregate,” Stand. test method Specif. gravity Absorpt., 2007.\n C. ASTM, “ASTM-C143: Standard test method for slump of hydraulic cement concrete, ASTM International, West Conshohocken, PA, USA,” vol. 4. 1996.\n BSI, “Standard: Testing hardened concrete. Compressive strength of test specimens/ BS EN 12390-3: 2009.” BRITISH STANDARD, 2011.\n S. Ahmad, S. A. Barbhuiya, A. Elahi, and J. Iqbal, “Effect of Pakistani bentonite on properties of mortar and concrete,” Clay Miner., vol. 46, no. 1, pp. 85–92, 2011, doi: https://doi.org/10.1180/claymin.2011.046.1.85.\n J. Mirza, M. Riaz, A. Naseer, F. Rehman, A. N. Khan, and Q. Ali, “Pakistani bentonite in mortars and concrete as low cost construction material,” Appl. Clay Sci., vol. 45, no. 4, pp. 220–226, 2009, doi: https://doi.org/10.1016/j.clay.2009.06.011.\n T. Akram, S. A. Memon, and K. Iqbal, “Utilization of bagasse ash as partial replacement of cement,” in International Conference on Advances in Cement Based Materials and Applications in Civil Infrastructure ACBM-ACI, Lahore, Pakistan, 2007, pp. 235–245.\n P. K. Mehta and P. J. M. Monteiro, Concrete microstructure, properties and materials. 2017.\n P. Monteiro, Concrete: microstructure, properties, and materials. McGraw-Hill Publishing, 2006.\n A. Nevill, G. Broxe, A. A. RamezanianPour, and N. Araby, Concrete Technology (Book). Tehran: Negarande Danesh, 2016.\n J. A. Bogas, J. de Brito, and J. M. Figueiredo, “Mechanical characterization of concrete produced with recycled lightweight expanded clay aggregate concrete,” J. Clean. Prod., vol. 89, pp. 187–195, 2015, doi: https://doi.org/10.1016/j.jclepro.2014.11.015.\n A. M. Neville, Properties of concrete, vol. 4. Longman London, 1995.\n H. Erfany, Crystallography (in Persian). Tehran: Tehran University.\n R. Falihy, “Causes of using sodium bicarbonate in cement slurry for injection in rocks (In Persian).”\n A. C. I. Committee and I. O. for Standardization, “Building code requirements for structural concrete (ACI 318-08) and commentary,” 2008.\n S.-C. Pan, D.-H. Tseng, C.-C. Lee, and C. Lee, “Influence of the fineness of sewage sludge ash on the mortar properties,” Cem. Concr. Res., vol. 33, no. 11, pp. 1749–1754, 2003, doi: https://doi.org/10.1016/S0008-8846(03)00165-0.\n B. B. Sabir, S. Wild, and J. Bai, “Metakaolin and calcined clays as pozzolans for concrete: a review,” Cem. Concr. Compos., vol. 23, no. 6, pp. 441–454, 2001, doi: https://doi.org/10.1016/S0958-9465(00)00092-5.\n M. J. Shannag, “High strength concrete containing natural pozzolan and silica fume,” Cem. Concr. Compos., vol. 22, no. 6, pp. 399–406, 2000, doi: https://doi.org/10.1016/S0958-9465(00)00037-8.\n A. Standard, “ASTM-C311-07: Standard Test Methods for Sampling and Testing Fly Ash or Natural Pozzolans for Use in Portland-Cement Concrete,” Annu. B. ASTM Stand., 2007.", "domain": "chemistry", "round": 3} +{"url": "https://www.hindawi.com/journals/jchem/2012/872509/", "date": "2022-08-08T14:00:19Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882570827.41/warc/CC-MAIN-20220808122331-20220808152331-00760.warc.gz", "language_score": 0.8596542477607727, "token_count": 267, "dump": "CC-MAIN-2022-33", "global_id": "webtext-fineweb__CC-MAIN-2022-33__0__92210526", "lang": "en", "text": "A. R. Massah, R. J. Kalbasi, M. Toghiani, B. Hojati, M. Adibnejad, \"Hydrotalcite as an Efficient and Reusable Catalyst for Acylation of Phenols, Amines and Thiols Under Solvent-free Conditions\", Journal of Chemistry, vol. 9, Article ID 872509, 8 pages, 2012. https://doi.org/10.1155/2012/872509\nHydrotalcite as an Efficient and Reusable Catalyst for Acylation of Phenols, Amines and Thiols Under Solvent-free Conditions\nA wide variety of alcohols, phenols, amines and thiols were efficiently acylated with carboxylic acid anhydrides and chlorides in the presence of Hydrotalcite under solvent-free conditions at room temperature in good to high yields. Eco-friendly conditions and reusability of the catalyst are the most important advantages of this protocol.\nCopyright © 2012 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.", "domain": "chemistry", "round": 3} +{"url": "https://www.barnardhealth.us/food-processing/other-ingredients.html", "date": "2020-02-18T13:19:12Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-10/segments/1581875143695.67/warc/CC-MAIN-20200218120100-20200218150100-00017.warc.gz", "language_score": 0.9501402378082275, "token_count": 677, "dump": "CC-MAIN-2020-10", "global_id": "webtext-fineweb__CC-MAIN-2020-10__0__37807563", "lang": "en", "text": "Ingredient water can have a significant effect on dough properties, but most production plants are able to develop formula modifications that offset any undesirable effects that might result from use of the water from their particular supply system. The water from any potable source, such as the municipal pipelines or a well, can be regarded as legally suitable for incorporation in a biscuit formula. However, it should not be necessary to say that any water that has an undesirable odor or flavor should be subjected to a purification process before it is mixed into a dough. The pH of the ingredient water supply, especially from municipal sources, can in some cases vary widely throughout the week or day, and this can cause the physical properties of the dough to change, adversely affecting the machining of this material.\nFresh milk and eggs are not common ingredients in most commercial cookies partly because they are relatively costly. When present, they are likely to constitute only a small percentage of the product. Eggs can have a substantial effect on the physical properties of a dough or batter, acting as a structure former, leavener (due to entrapment of air and water vapor), emulsifier, and lubricants. Egg whites are better as a structure former and leavener; yolks are more effective as an emulsifier and lubricant. Eggs do affect flavor, not always positively, and yolks add color, usually a desirable result. Nonfat milk has ambivalent results on structure while whole milk generally has a weakening effect due to the fat. Both milk and eggs add good-\nquality protein to a biscuit and are sometimes used as a wash on the surface to color or glaze the finished piece, but for some consumers, cholesterol concerns may be a negative attribute.\nSalt is an important ingredient. Not only is it an essential flavor-enhancing ingredient in any baked product, but it has effects on the physical characteristics of doughs. Some of these effects may be favorable, such as the slight toughening effect it has on some doughs, and others are considered unfavorable, such as its retarding effect on yeast-leavened systems, when incorporated at high levels.\nCrackers and especially cookies are susceptible to rancidity, because of their high fat content and their fairly long shelf life. Antioxidants can counteract this tendency to a considerable degree. Common antioxidants are butylated hydroxyanisol (BHA), butylated hydroxytoluene (BHT), and ieri-butylhydroquinone (TBHQ). Amounts that can be added are restricted by federal regulations, and antioxidants must be labeled as cancer-causing agents in some states and may be banned outright in certain countries. Citric acid and phosphoric acid are sometimes useful for chelating metal ions that would otherwise accelerate rancidity. Research has shown that some natural tocopherols (vitamin E) and other antioxidants (rosemary extract) can prevent oxidation.\nWas this article helpful?\nA beginners guide that will reveal how living \"G\" free can help you lose weight today! This is not a fad diet, or short term weight loss program that sometimes makes you worse off than before you started. This is a necessity for some people and is prescribed to 1 out of every 100 people on earth by doctors and health professionals.", "domain": "chemistry", "round": 3} +{"url": "https://como.ceb.cam.ac.uk/people/ak2332/", "date": "2022-05-28T23:54:51Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-21/segments/1652663021405.92/warc/CC-MAIN-20220528220030-20220529010030-00463.warc.gz", "language_score": 0.8970162868499756, "token_count": 276, "dump": "CC-MAIN-2022-21", "global_id": "webtext-fineweb__CC-MAIN-2022-21__0__171149012", "lang": "en", "text": "Affiliated Research Fellow\nAleksandar studied chemistry at Jacobs University Bremen in Germany. For his graduate studies, he followed the Nanomolecular Science program at the same university, during which he familiarized himself with the synthesis and characterization of nanoscopic metal oxides, that is, polyoxometalates (POMs). Under the mentorship of Prof. Thomas Heine, he learned about the application of density functional theory methods to describe POMs. Following his promotion in 2016, he completed postdoctoral stages at RWTH Aachen (Germany) and at KU Leuven (Belgium). He has recently joined the group of Prof. Markus Kraft as a Feodor Lynen Fellow. His current research is in the domain of computational modelling and the development of knowledge graphs for functional nanomolecular materials.\n292: Automated Rational Design of Metal-Organic Polyhedra\nMarkus Kraft, Technical Report 292, c4e-Preprint Series, Cambridge, 2022.", "domain": "chemistry", "round": 3} +{"url": "https://www.innovations-report.com/html/reports/medical-technology/fraunhofer-item-takes-over-and-continues-development-of-inhalation-technology-assets-from-takeda.html", "date": "2018-07-21T12:17:08Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-30/segments/1531676592523.89/warc/CC-MAIN-20180721110117-20180721130117-00236.warc.gz", "language_score": 0.885929524898529, "token_count": 1255, "dump": "CC-MAIN-2018-30", "global_id": "webtext-fineweb__CC-MAIN-2018-30__0__21444538", "lang": "en", "text": "The Fraunhofer-Gesellschaft, on behalf of the Fraunhofer Institute for Toxicology and Experimental Medicine ITEM, has signed an asset transfer agreement with Takeda GmbH to exclusively transfer its Surfactant and Continuous Powder Aerosolization (CPA) program assets to Fraunhofer ITEM.\nThe transfer includes the CPA technology for continuous aerosolization of powdery substances and the know-how to manufacture recombinant surfactant protein C, together with the associated intellectual property. The Fraunhofer ITEM is thus in a position to continue the development of therapies involving continuous inhalation various medications, begun 10 years ago.\nClosing down its respiratory department, Takeda transferred its Surfactant and CPA program assets to Fraunhofer ITEM including the associated intellectual property. The CPA technology is the first non-invasive administration method for powdery surfactant drugs.\nSurfactant drugs have to be administered to patients with surfactant deficiency, which is common, for example, in preterm in neonates. Furthermore, this therapeutic approach has been investigated in other acute and chronic life-threatening diseases such as acute lung injury and COPD.\nSurfactant (“surface-active agent“) is secreted by certain lung cells und reduces surface tension in the alveoli, thereby preventing their collapse. Physical activity causes an increase, smoking a decrease in surfactant production. Fetal surfactant production starts in week 24 of gestation. Preterm neonates, in particular if born before week 34 of gestation, suffer from varying degrees of pulmonary surfactant deficiency, which may lead to neonate respiratory distress syndrome.\nSurfactant-based therapy is the standard of care. Its use is limited, however, due to the currently invasive administration methodology. The CPA technology simplifies surfactant delivery to neonates and can also be used for children and adults. Recombinant surfactant protein C is the first recombinant surfactant protein suitable for use in synthetic surfactant drugs.\nCPA is also a suitable technology to continuously deliver pulmonary high doses of non-soluble drugs to patients. In respiratory care, the standard of aerosolization for continuous inhalation is currently confined to different classes of nebulizers. In contrast, the CPA technology for the first time enables continuous inhaled administration of non-soluble drugs. In addition, it delivers a higher drug concentration to patients and enables a higher lung deposition rate.\nDr. Gerhard Pohlmann, Head of Medical Inhalation Technology at Fraunhofer ITEM with a 10+ year track record in CPA technology development, said: “As a long-standing partner in the CPA program, Fraunhofer ITEM is delighted to continue development of the surfactant and CPA technology platform. We are currently in the strategic process of reorganizing the program and selecting development partners.”\nDr. Gerhard Pohlmann; +49 511 5350-116\nDr. Cathrin Nastevska; +49 511 5350-225\nThe text of this press release can be found on our homepage at\nDr. Cathrin Nastevska | Fraunhofer Institute for Toxicology and Experimental Medicine\nA first look at interstitial fluid flow in the brain\n05.07.2018 | American Institute of Physics\nA sentinel to watch over ocular pressure\n04.07.2018 | Fraunhofer Institute for Microelectronic Circuits and Systems\nA new manufacturing technique uses a process similar to newspaper printing to form smoother and more flexible metals for making ultrafast electronic devices.\nThe low-cost process, developed by Purdue University researchers, combines tools already used in industry for manufacturing metals on a large scale, but uses...\nFor the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.\nTo rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...\nFor the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.\nWhirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...\nPhysicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.\nA frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...\nOptical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.\n\"Put an excitation into the system and observe how it evolves.\" According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....\n13.07.2018 | Event News\n12.07.2018 | Event News\n03.07.2018 | Event News\n20.07.2018 | Power and Electrical Engineering\n20.07.2018 | Information Technology\n20.07.2018 | Materials Sciences", "domain": "chemistry", "round": 3} +{"url": "http://www.housedelic.com/4-household-liquids-youve-been-improperly-disposing/", "date": "2018-03-17T12:22:37Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-13/segments/1521257645069.15/warc/CC-MAIN-20180317120247-20180317140247-00361.warc.gz", "language_score": 0.9327661395072937, "token_count": 714, "dump": "CC-MAIN-2018-13", "global_id": "webtext-fineweb__CC-MAIN-2018-13__0__63705558", "lang": "en", "text": "The average home contains a large variety of liquid products. They help us to cook, clean and decorate our home. When it comes time to throw these products out, simply tossing the liquid in the garbage, or down the drain, can have devastating results.\nNot only can certain products damage the environment, but they can harm the individuals collecting, and transporting the waste.\nYou should educate yourself on the proper liquid waste disposal methods to avoid damaging your home and the environment.\n1. Fats, Oils and Grease\nThe fat, oil, and grease commonly produced from cooking, should not be wrongly disposed of. Simply pouring cooking grease down the drain, can seriously affect your pipes. Grease can harden, and clog the drainage system. Ultimately leading to backups, clogs or leaks.\nThe proper way to dispose of grease is to allow it to harden. To do this, take the remaining oil from your cooking, and pour it into a cup. Then, place the cup in the fridge, or freezer, to harden. Once it has become a solid, you’re safe to dispose of it in your compost.\n2. Automotive Products\nProducts used on your car, should never be poured down the drain, or tossed in the trash. Automotive products are items such as: antifreeze, motor oil, polish and wax. These products contain countless hazardous materials that can be dangerous if improperly handled. These chemicals are harmful to the environment, animals, and people.\nWhen it comes time for you to dispose of them, there are proper steps to follow. Keep these items sealed, in their original container, and separate. Then, contact your local municipality, so they can direct you to a specialty waste depot that can accept the products, or schedule a time to pick them up from you.\nIt is not uncommon to find old paint cans hanging around a home. But, what happens when it is time to get rid of them? Paint is considered a hazardous material, and therefore should be treated as such. It is imperative not to pour any excess paint down the drain, or into the ground. Doing so can cause serious harm to both your plumbing system, and the environment.\nTo properly dispose of paint, remove the lid of the can, and let the contents of it dry out. To speed up this process, use an absorbent material, such as kitty litter, or sawdust. You are then able to throw the absorbent material into the garbage, and the dry paint can, into the recycling.\n4. Cleaning Products\nSurprisingly, the majority of cleaning products can be disposed of down your household drain. A simple rule to follow is that: if the cleaner mixes with water, it can be disposed of down your drain. Just take the remaining solution, and with the water running, pour it down. It is important to ensure that no residue, or liquid, remains in the container, prior to recycling. If there is any remaining liquid, it can cause leaks, or harm the individuals handing it. So, ensure that the containers are carefully rinsed prior to tossing.\nHowever, for more specialized cleaners, such as furniture polish, or oven cleaner, it is essential to read the disposal instructions carefully. If you are unsure of how to dispose of an item, simply call your local waste site, or municipality. They will be able to guide you on the proper disposal method, guaranteeing no harm to your home, or the environment.", "domain": "chemistry", "round": 3} +{"url": "http://academic.research.microsoft.com/Publication/49476375/syntheses-and-initial-evaluation-of-a-series-of-indolo-fused-heterocyclic-inhibitors-of-the", "date": "2014-12-19T23:33:58Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2014-52/segments/1418802768982.112/warc/CC-MAIN-20141217075248-00119-ip-10-231-17-201.ec2.internal.warc.gz", "language_score": 0.7386528253555298, "token_count": 297, "dump": "CC-MAIN-2014-52", "global_id": "webtext-fineweb__CC-MAIN-2014-52__0__185160216", "lang": "en", "text": "Syntheses and initial evaluation of a series of indolo-fused heterocyclic inhibitors of the polymerase enzyme (NS5B) of the hepatitis C virus\nXiaofan Zheng, Thomas W. Hudyma, Scott W. Martin, Carl Bergstrom, Min Ding, Feng He, Jeffrey Romine, Michael A. Poss, John F. Kadow, Chong-Hwan Chang, John Wan, Mark R. Witmerhttp://academic.research.microsoft.com/io.ashx?type=5&id=49476375&selfId1=0&selfId2=0&maxNumber=12&query=\nHerein, we present initial SAR studies on a series of bridged 2-arylindole-based NS5B inhibitors. The introduction of bridging elements between the indole N1 and the ortho-position of the 2-aryl moiety resulted in conformationally constrained heterocycles that possess multiple additional vectors for further exploration. The binding mode and pharmacokinetic (PK) properties of select examples, including: 13-cyclohexyl-6-oxo-6,7-dihydro-5H-indolo[2,1-d][1,4]benzodiazepine-10-carboxylic acid (7) (IC50=0.07μM, %F=18), are reported.", "domain": "chemistry", "round": 3} +{"url": "https://irrigationinnovation.org/library/soil-physical-properties-and-aggregate-associated-c-n-and-p-distributions-in-organic-and-conventional-cropping-systems/", "date": "2022-01-17T23:21:58Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-05/segments/1642320300624.10/warc/CC-MAIN-20220117212242-20220118002242-00384.warc.gz", "language_score": 0.8399096727371216, "token_count": 775, "dump": "CC-MAIN-2022-05", "global_id": "webtext-fineweb__CC-MAIN-2022-05__0__226701804", "lang": "en", "text": "|Author:||Green, V. S. ; Cavigelli, M. A. ; Dao, T. H. ; Flanagan,D. C.|\n|Book Group Author:||NA|\nOrganic farming, which is growing in popularity, has been proposed as a sustainable alternative to conventional farming practices. However, it is not known how organic farming systems affect soil erosion risk and sediment-bound nutrient transport. Our objectives were to compare soil erosion risk and sediment bound nutrient transport potential for grain-based conventional and organic cropping systems by determining selected soil physical properties and distributions of carbon (C), nitrogen (N), and phosphorus (P) in soil aggregates of the 0-5 cm depth of a Christiana-Matapeake-Keyport soil association. We measured soil bulk density, aggregate stability, aggregate size distributions, and total C, N, and P associated with five soil aggregate size classes in no-till (NT) and chisel till (CT) systems and in an organic system (ORG). No-till soils had lesser bulk density and greater aggregate stability than did CT and ORG soils. Carbon, N, and P concentrations were greater in large (>2.00 mm) and small macroaggregates (0.21 to 2.00 mm) than in microaggregates (<0.21 mm) regardless of cropping system. When nutrient concentrations were combined with aggregate distribution data, the quantity of aggregate associated nutrients was greatest in microaggregates in ORG and CT soils but greatest in macroaggregates in NT soils. These results indicate an increased risk of sediment associated nutrient transport from ORG and CT soils compared with NT soils, since microaggregates in these soils are preferentially lost through sediment transport. The NT cropping system promoted macroaggregate formation and reduced the risk of particulate nutrient transport in this warm, humid region soil.\n|Pages:||822 - 831|\naggregates, bulk density, carbon, cropping systems, erosion,farming systems, geological sedimentation, nitrogen, no-tillage,nutrient content, organic farming, particle size distribution,phosphorus, soil density, soil physical properties, soil types, spatialdistribution, sustainability, Ultisols, Maryland, USA, South AtlanticStates of USA, Southern States of USA, USA, North America, America,Developed Countries, OECD Countries, Plant Cropping Systems (FF150),Soil Chemistry and Mineralogy (JJ200), Soil Physics (JJ300), SoilFertility (JJ600), Soil Management (JJ900), Erosion; Soil and WaterConservation (PP400)", "domain": "chemistry", "round": 3} +{"url": "https://cherry.chem.bg.ac.rs/handle/123456789/308", "date": "2020-11-27T00:31:52Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-50/segments/1606141189030.27/warc/CC-MAIN-20201126230216-20201127020216-00585.warc.gz", "language_score": 0.9098849296569824, "token_count": 294, "dump": "CC-MAIN-2020-50", "global_id": "webtext-fineweb__CC-MAIN-2020-50__0__81788807", "lang": "en", "text": "Book part (Published version)\nMetadataShow full item record\nAllergic reactions to peanuts are a major cause of food-induced anaphylaxis, both in children and adults. It is estimated that approximately 1% of the world’s population developed allergy to peanuts and the prevalence is exhibiting an increasing trend. Sensitization by peanut proteins is suspected to develop directly by ingestion of food containing peanuts or processed peanut proteins or through skin, using cosmetic products containing peanut oil and some peanut proteins. In this chapter, biochemical properties of major peanut allergens (Ara h 1, Ara h 2, Ara h 3 and Ara h 6) are thoroughly reviewed with emphasis on structural similarity to proteins from other sources which is frequently resulting in cross-reactivity. Recently reported peanut proteins are briefly described (Ara h 7-17). Methodologies for detecting minute amounts of peanuts in different sources will be improved by further advancement of knowledge on peanut allergens. Hopefully, the potential threat to peanut-allergic pe...rsons produced by contamination of food by trace amounts of peanuts and their proteins will be diminished. © 2017 by Nova Science Publishers, Inc. All rights reserved.\nKeywords:Ara h 1 / Ara h 2 / Ara h 3 / Ara h 6 / Arachis hypogea L. / Major peanut allergens / Minor peanut allergens / Peanut allergy\n- Peanuts: Consumption, Allergies and Nutritional Content", "domain": "chemistry", "round": 3} +{"url": "https://m.hugendubel.de/de/buch/-membrane_technology_applications_to_industrial_wastewater_treatment-2748599-produkt-details.html", "date": "2017-05-25T20:31:11Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-22/segments/1495463608416.96/warc/CC-MAIN-20170525195400-20170525215400-00545.warc.gz", "language_score": 0.7232568860054016, "token_count": 611, "dump": "CC-MAIN-2017-22", "global_id": "webtext-fineweb__CC-MAIN-2017-22__0__139272641", "lang": "en", "text": "Membrane Technology: Applications to Industrial Wastewater Treatment\nLieferbar innerhalb von 2-3 Tagen\nBeschreibungThis publication presents the lectures given at the course on Advanced Separation Technology for Industrial Waste Minimization: Environmental and Analytical Aspects (13-15 October, 1992, Ispra, Italy) organized jointly by the Technical University of Lisbon, University of Calabria and the Environment Institute of the Joint Research Centre of the Commission of the European Communities at Ispra. This course is integrated in a programme for education and training in Advanced Separation Technology for Industrial Waste Minimization supported by the Community Action Programme for Education and Training for Technology (COMETT II). The lecture material is based on case studies of importance to textile, tanneries, pulp and paper, metal finishing and electroplating, food, and other industries. Environmental regulations have lead industrial engineers to search for more efficient, less energy consuming and less waste producing processes. Membrane-based separation processes contributed to recover water, raw materials and energy and to achieve simultaneously pollution control. Along this book emphasis will be given to this fast growing area of process technology.\nInhaltsverzeichnisPreface. Effective Membrane Processes: New Perspectives; E. Drioli. Photosynthetic Membranes in Industrial Waste Minimization and Recovery of Valuable Products; I.R. Bellobono. The Industrial Development of Polymeric Membranes and Membrane Modules for Reverse Osmosis and Ultrafiltration; S.N. Gaeta. Existing Industrial Membrane Applications: Results and Perspectives; A.T. Caetano. Treatment of Bleaching Effluents by Pressure-Driven Membrane Processes: a Review; M.D. Afonso, M.N. De Pinho. Industrial Experiences of Treatment of Textile Effluents by Membrane Processes; U. Fedele. Biotechnological Applications of Membrane Systems in the Agro-Food Industry; G. Iorio, V. Calabrò. Application of Membrane Separation Techniques to the Treatment of Tanneries Wastewaters; R. Molinari. Hazardous Waste Reduction in the Metal-Finishing Industry; F. Frenquellucci. Membrane Application in Food Industry; M. Pizzichini. Purification of Landfill Leachate with Reverse Osmosis and DT-Module; Th.A. Peters. Membrane Introduction Mass Spectrometry for On-Site Monitoring of Waste Water; S. Facchetti. Environmental Aspects of Liquid Waste and Water Treatment; H. Muntau.\nUntertitel: 'Environmental Science and Technology Library'. 1995. Auflage. Book. Sprache: Englisch.\nErscheinungsdatum: November 1994\nSeitenanzahl: 212 Seiten", "domain": "chemistry", "round": 3} +{"url": "https://orbit.dtu.dk/en/publications/simulating-serial-target-antibacterial-drug-synergies-using-flux-", "date": "2020-08-11T16:54:29Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-34/segments/1596439738816.7/warc/CC-MAIN-20200811150134-20200811180134-00264.warc.gz", "language_score": 0.8542718291282654, "token_count": 337, "dump": "CC-MAIN-2020-34", "global_id": "webtext-fineweb__CC-MAIN-2020-34__0__86027245", "lang": "en", "text": "Flux balance analysis (FBA) is an increasingly useful approach for modeling the behavior of metabolic systems. However, standard FBA modeling of genetic knockouts cannot predict drug combination synergies observed between serial metabolic targets, even though such synergies give rise to some of the most widely used antibiotic treatments. Here we extend FBA modeling to simulate responses to chemical inhibitors at varying concentrations, by diverting enzymatic flux to a waste reaction. This flux diversion yields very similar qualitative predictions to prior methods for single target activity. However, we find very different predictions for combinations, where flux diversion, which mimics the kinetics of competitive metabolic inhibitors, can explain serial target synergies between metabolic enzyme inhibitors that we confirmed in Escherichia coli cultures. FBA flux diversion opens the possibility for more accurate genome-scale predictions of drug synergies, which can be used to suggest treatments for infections and other diseases.\nBibliographical note© 2016 Krueger et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.\nKrueger, A. S., Munck, C., Dantas, G., Church, G. M., Galagan, J., Lehár, J., & Sommer, M. O. A. (2016). Simulating Serial-Target Antibacterial Drug Synergies Using Flux Balance Analysis. P L o S One, 11(1), [e0147651]. https://doi.org/10.1371/journal.pone.0147651", "domain": "chemistry", "round": 3} +{"url": "https://www.imperial.ac.uk/tate-group/publications/?id=870&limit=10&respub-action=search.html&page=5", "date": "2024-04-14T06:52:14Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712296816875.61/warc/CC-MAIN-20240414064633-20240414094633-00214.warc.gz", "language_score": 0.8690572381019592, "token_count": 1482, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__188718915", "lang": "en", "text": "- Showing results for:\n- Reset all filters\nJournal articleShchepinova MM, Hanyaloglu AC, Frost GS, et al., 2020,\nJournal articlede Chiara C, Homsak M, Prosser GA, et al., 2020,\nJournal articleAnderson DP, Benns HJ, Tate EW, et al., 2020,\nRational molecular engineering of proteins with CRISPR-based approaches is challenged by the gene-centric nature of gRNA design tools. To address this, we have developed CRISPR-TAPE, a protein-centric gRNA design algorithm that allows users to target specific residues, or amino acid types within proteins. gRNA outputs can be customized to support maximal efficacy of homology-directed repair for engineering purposes, removing time-consuming post hoc curation, simplifying gRNA outputs and reducing CPU times.\nJournal articleKounde C, Shchepinova M, Saunders C, et al., 2020,\nWith the intent of achieving greater spatiotemporal control of PROTAC-induced protein degradation, a light-activated degrader was designed by photocaging an essential E3 ligase binding motif in a BRD4 targeting PROTAC. Proteolysis was triggered only after a short irradiation time, the kinetics of which could be monitored by live-cell video microscopy.\nJournal articleWard JA, Pinto-Fernandez A, Cornelissen L, et al., 2020,\nJournal articleTzakoniati F, Xu H, Garcia N, et al., 2020,\nDevelopment of photocrosslinking probes based on Huwentoxin-IV to map the site of interaction on Nav1.7, Cell Chemical Biology, Vol: 27, Pages: 306-313.e4, ISSN: 2451-9456\nVoltage-gated sodium (Nav) channels respond to changes in the membrane potential of excitable cells through the concerted action of four voltage-sensor domains (VSDs). Subtype Nav1.7 plays an important role in the propagation of signals in pain-sensing neurons and is a target for the clinical development of novel analgesics. Certain inhibitory cystine knot (ICK) peptides produced by venomous animals potently modulate Nav1.7, however the molecular mechanisms underlying their selective binding and activity remain elusive. This study reports on the design of a library of photoprobes based on the potent spider toxin Huwentoxin-IV and the determination of the toxin binding interface on VSD2 of Nav1.7 through a photocrosslinking and tandem mass spectrometry approach. Our Huwentoxin-IV probes selectively crosslink to extracellular loop S1-2 and helix S3 of VSD2 in a chimeric channel system. Our results provide a strategy that will enable mapping of sites of interaction of other ICK peptides on Nav channels.\nJournal articleRueda-Zubiaurre A, Yahiya S, Fischer O, et al., 2020,\nStructure-activity relationship studies of a novel class of transmission blocking antimalarials targeting male gametes., Journal of Medicinal Chemistry, Vol: 63, Pages: 2240-2262, ISSN: 0022-2623\nMalaria is still a leading cause of mortality among children in the developing world, and despite the immense progress made in reducing the global burden, further efforts are needed if eradication is to be achieved. In this context, targeting transmission is widely recognized as a necessary intervention towards that goal. After carrying out a screen to discover new transmission-blocking agents, herein we report our medicinal chemistry efforts to study the potential of the most robust hit, DDD01035881, as a male-gamete targeted compound. We reveal key structural features for the activity of this series and identify analogues with greater potency and improved metabolic stability. We believe this study lays the groundwork for further development of this series as a transmission blocking agent.\nJournal articleDian C, Inmaculada P-D, Riviere F, et al., 2020,\nHigh-resolution snapshots of human N-myristoyltransferase in action illuminate a mechanism promoting N-terminal Lys and Gly myristoylation, Nature Communications, Vol: 11, Pages: 1-15, ISSN: 2041-1723\nThe promising drug target N-myristoyltransferase (NMT) catalyses an essential protein modification thought to occur exclusively at N-terminal glycines (Gly). Here, we present high-resolution human NMT1 structures co-crystallised with reactive cognate lipid and peptide substrates, revealing high-resolution snapshots of the entire catalytic mechanism from the initial to final reaction states. Structural comparisons, together with biochemical analysis, provide unforeseen details about how NMT1 reaches a catalytically competent conformation in which the reactive groups are brought into close proximity to enable catalysis. We demonstrate that this mechanism further supports efficient and unprecedented myristoylation of an N-terminal lysine side chain, providing evidence that NMT acts both as N-terminal-lysine and glycine myristoyltransferase.\nJournal articleLucy D, Zhang L, Tate EW, 2020,\nJournal articleHoward RT, Hemsley P, Petteruti P, et al., 2020,\nStructure-guided design and in-cell target profiling of a cell-active target engagement probe for PARP inhibitors, ACS Chemical Biology, Vol: 15, Pages: 325-333, ISSN: 1554-8929\nInhibition of the poly(ADP-ribose) polymerase (PARP) family of enzymes has become an attractive therapeutic strategy in oncology and beyond; however, chemical tools to profile PARP engagement in live cells are lacking. Herein, we report the design and application of PARPYnD, the first photoaffinity probe (AfBP) for PARP enzymes based on triple PARP1/2/6 inhibitor AZ9482, which induces multipolar spindle (MPS) formation in breast cancer cells. PARPYnD is a robust tool for profiling PARP1/2 and is used to profile clinical PARP inhibitor olaparib, identifying several novel off-target proteins. Surprisingly, while PARPYnD can enrich recombinant PARP6 spiked into cellular lysates and inhibits PARP6 in cell-free assays, it does not label PARP6 in intact cells. These data highlight an intriguing biomolecular disparity between recombinant and endogenous PARP6. PARPYnD provides a new approach to expand our knowledge of the targets of this class of compounds and the mechanisms of action of PARP inhibitors in cancer.\nThis data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.", "domain": "chemistry", "round": 3} +{"url": "http://www.abcam.com/AKT1-2-3-antibody-ab106693.html", "date": "2013-05-18T16:55:43Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2013-20/segments/1368696382560/warc/CC-MAIN-20130516092622-00035-ip-10-60-113-184.ec2.internal.warc.gz", "language_score": 0.6832192540168762, "token_count": 1610, "dump": "CC-MAIN-2013-20", "global_id": "webtext-fineweb__CC-MAIN-2013-20__0__17399680", "lang": "en", "text": "Anti-AKT1/2/3 antibody (ab106693)\n- Product nameAnti-AKT1/2/3 antibodySee all AKT1/2/3 primary antibodies ...\n- DescriptionRabbit polyclonal to AKT1/2/3\n- Tested applicationsWB, IP, ELISA, IHC-P, ICC/IF more details\n- Species reactivityReacts with: Mouse, Rat, Chicken, Human\nPredicted to work with: Sheep, Goat, Cow, Dog, Pig\nSynthetic peptide: CRPHFPQFSYSASGTA conjugated to KLH using maleimide, corresponding to C terminal amino acids 466-480 of Human, Mouse, Rat and Chicken AKT1/2/3.\n- Positive controlHuman colon tumour tissue, Human liver tissue, Cultured neonatal rat cardiomyocytes expressing an AKT construct\n- Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.\n- Storage bufferPreservative: 0.1% Sodium Azide\nConstituents: 0.15M Sodium chloride, 0.02M Potassium phosphate, pH 7.2\n- Concentration information loading...\n- Purification notesDelipidation and Defibrination\n- Clonality Polyclonal\n- Research Areas\nOur Abpromise guarantee covers the use of ab106693 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\n|WB||WB: 1/500 - 1/2000. Predicted molecular weight: 56 kDa.Can be blocked with AKT1 peptide (466/480) (ab9041).|\n|IP||IP: Use at an assay dependent dilution.|\n|ELISA||ELISA: 1/2000 - 1/10000.|\n|IHC-P||IHC-P: 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.|\n|ICC/IF||ICC/IF: 1/100 - 1/1000.|\n- FunctionIGF-1 leads to the activation of AKT3, which may play a role in regulating cell survival. Capable of phosphorylating several known proteins. Truncated isoform 2/PKB gamma 1 without the second serine phosphorylation site could still be stimulated but to a lesser extent.\n- Tissue specificityIn adult tissues, it is highly expressed in brain, lung and kidney, but weakly in heart, testis and liver. In fetal tissues, it is highly expressed in heart, liver and brain and not at all in kidney.\n- Sequence similaritiesBelongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.\nContains 1 AGC-kinase C-terminal domain.\nContains 1 PH domain.\nContains 1 protein kinase domain.\n- DomainBinding of the PH domain to the phosphatidylinositol 3-kinase alpha (PI(3)K) results in its targeting to the plasma membrane.\nmodificationsPhosphorylation on Thr-305 and Ser-472 is required for full activity (By similarity). Phosphorylated upon DNA damage, probably by ATM or ATR.\nUbiquitinated. When fully phosphorylated and translocated into the nucleus, undergoes 'Lys-48'-polyubiquitination catalyzed by TTC3, leading to its degradation by the proteasome.\n- Cellular localizationCytoplasm. Membrane. Membrane-associated after cell stimulation leading to its translocation.\n- Entrez Gene: 208 Human\n- Entrez Gene: 207 Human\n- Entrez Gene: 10000 Human\n- Entrez Gene: 11651 Mouse\n- Entrez Gene: 11652 Mouse\n- Entrez Gene: 23797 Mouse\n- Entrez Gene: 24185 Rat\n- Entrez Gene: 25233 Rat\n- Entrez Gene: 29414 Rat\n- Omim: 164730 Human\n- Omim: 164731 Human\n- Omim: 611223 Human\n- SwissProt: P31749 Human\n- SwissProt: P31751 Human\n- SwissProt: Q9Y243 Human\n- SwissProt: P31750 Mouse\n- SwissProt: Q60823 Mouse\n- SwissProt: Q9WUA6 Mouse\n- SwissProt: P47196 Rat\n- SwissProt: P47197 Rat\n- SwissProt: Q63484 Rat\n- Unigene: 525622 Human\n- Unigene: 631535 Human\n- Unigene: 498292 Human\n- Unigene: 235194 Mouse\n- Unigene: 11422 Rat\n- Unigene: 87066 Rat\n- Unigene: 10506 Rat\n- AKT antibodyAKT1 antibodyAKT1 kinase antibody\n- AKT2 antibodyAKT2 kinase antibodyAkt3 antibodyAKT3_HUMAN antibodyCAKT antibodyDKFZp434N0250 antibodykinase Akt1 antibodyMGC99656 antibodyMurine thymoma viral (v-akt) homolog 2 antibodyPKB antibodyPKB gamma antibodyPKB-GAMMA antibodyPKB/Akt antibodyPKBALPHA antibodyPKBB antibodyPKBBETA antibodyPKBG antibodyPKBGAMMA antibodyPRKBA antibodyPRKBB antibodyPRKBG antibodyProtein kinase Akt-3 antibodyProtein kinase B antibodyProtein kinase B gamma antibodyRAC antibodyrac protein kinase alpha antibodyrac protein kinase beta antibodyRAC-gamma antibodyRAC-gamma serine/threonine-protein kinase antibodyRAC-PK-gamma antibodyRACALPHA antibodyRACalpha serine/threonine kinase antibodyRACBETA antibodyRACgamma antibodyRACgamma serine/threonine protein kinase antibodyRACPKgamma antibodyserine threonine protein kinase antibodySTK-2 antibodySTK2 antibodythymoma viral proto oncogene 1 antibodythymoma viral proto oncogene antibodyvakt murine thymoma viral oncogene homolog 1 antibodyvakt murine thymoma viral oncogene homolog 2 antibodyvakt murine thymoma viral oncogene homolog 3 antibody\nAnti-AKT1/2/3 antibody images\nab106693, at 1/100 dilution, staing AKT1/2/3 in Human liver followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.\nab106693 at 1/100 dilution, staining AKT1/2/3 in Human colon, A) normal tissue B) tumour tissue.\nab106693, at 1/80 dilution, staining AKT1/2/3 in cultured neonatal Rat cardiomyocytes that express a nuclear-targeted AKT construct. Anti-AKT1/2/3 staining appears green. Actin filaments are labeled red using a Texas-red™ conjugated phalloidin.\nReferences for Anti-AKT1/2/3 antibody (ab106693)\nab106693 has not yet been referenced specifically in any publications.", "domain": "chemistry", "round": 3} +{"url": "http://ceramics.org/ema2017-symposium7", "date": "2018-09-21T12:14:40Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-39/segments/1537267157070.28/warc/CC-MAIN-20180921112207-20180921132607-00494.warc.gz", "language_score": 0.8486658334732056, "token_count": 280, "dump": "CC-MAIN-2018-39", "global_id": "webtext-fineweb__CC-MAIN-2018-39__0__106427554", "lang": "en", "text": "SYMPOSIUM 7: In Situ Experiments of Microstructure Evolution and Properties\nEmerging in situ techniques for property and microstructure characterization have shed new light on the mechanisms responsible for fundamental material properties, and microstructural evolution. This symposium will include presentations dealing with experimentation and analysis, kinetics, and mechanisms responsible for microstructural evolution interpreted from in situ studies. The contributions will highlight how in situ techniques have influenced our understanding of mechanisms for materials response at the atomic, nano, and microstructural length scales. In situ techniques highlighted include but are not limited to electron microscopy, photon-based techniques, and scanning probe methods. The goal of the symposium is to highlight the important scientific insights into structural and functional oxides and ceramics gained from in situ techniques.\n- Interfacial reactions and processes in complex environments;\n- Mechanisms for micro- and nano-structural evolution;\n- Knowledge gained from in situ mechanical testing of ceramic-based systems;\n- Understanding the dynamic response of functional systems through in situ testing;\n- New insights into atomistic processes at high temperatures or in extreme environments.\nWayne D. Kaplan, Technion Israel Institute of Technology, Israel, email@example.com\nShen Dillon, University of Illinois at Urbana Champaign, firstname.lastname@example.org", "domain": "chemistry", "round": 3} +{"url": "https://pubmed.ncbi.nlm.nih.gov/14505311/?dopt=Abstract", "date": "2021-12-07T18:04:41Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-49/segments/1637964363405.77/warc/CC-MAIN-20211207170825-20211207200825-00480.warc.gz", "language_score": 0.9012755751609802, "token_count": 420, "dump": "CC-MAIN-2021-49", "global_id": "webtext-fineweb__CC-MAIN-2021-49__0__62593410", "lang": "en", "text": "Background: Recent advances in intracellular staining techniques, cytometer technology, fluorescent reagents, and antibody production have expanded the number of intracellular antigens that can be analyzed by flow cytometry. Measurement of protein phosphorylation with phospho-specific antibodies has given insight into kinase signaling cascades. However, available techniques for phospho-epitope staining can differ greatly, making it necessary to understand the differences between the outcomes when such techniques are applied and to develop robust and reproducible methods of application.\nMethods: Ten different cellular fixation and permeabilization techniques were tested for their ability to provide phospho-specific staining. Combinations of formaldehyde, methanol, ethanol, acetone, Triton X-100, and saponin were used as fixation and permeabilization reagents. Phospho-specific antibodies were labeled with Alexa Fluor dyes to provide multicolor analysis of different signaling events simultaneously within individual cells.\nResults: Fixing cells with 1.5% formaldehyde followed by permeabilization in methanol gave optimal results for pERK, pp38, pJNK, pStat1, pStat5, and pStat6 staining. Alteration of formaldehyde fixation and methanol permeabilization times affected measurements of phosphorylation induction. Phospho-specific flow cytometric analyses correlated well with Western blotting, providing cross platform validation of the technique.\nConclusions: Measuring phosphorylation events by flow cytometry provides a rapid and efficient way to measure kinase cascades in individual cells. Stability of phospho-epitopes in methanol allows long-term storage of samples prior to analysis. Multiple signaling cascades can be monitored simultaneously through the use of different fluorophore labels to determine specificity of ligands or inhibitors. Application of optimized techniques to heterogeneous cell types such as peripheral blood or murine splenocytes may allow signaling to be analyzed simultaneously in immune cell subsets.\nCopyright 2003 Wiley-Liss, Inc.", "domain": "chemistry", "round": 3} +{"url": "https://www.comolube.com/product/micro-plate-epmoly-2-grease-400-lb-drum/", "date": "2024-04-19T16:32:41Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712296817438.43/warc/CC-MAIN-20240419141145-20240419171145-00552.warc.gz", "language_score": 0.864828884601593, "token_count": 458, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__42618666", "lang": "en", "text": "MICRO-PLATE EP/MOLY 2 Grease – 400 Lb Drum\nMICRO-PLATE EP/MOLY Grease is a high quality, multi-purpose 12-hydroxystearate lithium, extreme pressure grease, designed for the lubrication of heavy duty automotive and industrial equipment where heavy loads and wet conditions require a grease having high film strength with high resistances to water wash-out. Formulated with our exclusive “Lubricant-Within-A-Lubricant” that actually becomes part of frictional surfaces to which it is applied.\n- Additional information\n- Product Inquiry\nA unique combination of fluid molybdenum-disulfide (moly) and graphite compounds guarantee a continuous and tenacious protective film on all moving surfaces, regardless of load or severity of working conditions (lubricating solids effective to 750F).\nSpecial space-age additive package insures high film strength, extreme pressure and anti-wear properties.\nThe high dropping point permits use up to 375F, for intermittent periods, without loss of lubricating protection.\nA special “Lubricant-Within-A-Lubricant? technology, reduces operating temperatures by increasing the load bearing area which reduces unit pressures. This increases working life of both parts and grease, reduces power consumption and increases equipment efficiency, and allows extension of the normal lubrication cycle by two to five times.\nRecommended for lubrication of automotive chassis points including shackle pins, ball joint suspension units, and other parts, found in cars, trucks, trailer or construction equipment where shock load conditions are normal. Many manufacturers of automotive and industrial equipment recommend a grease fortified with molybdenum disulfide, making this grease suitable for chassis lubrication of late model automobiles with extended lubrication intervals, where the manufacturer recommends moly grease.\nExtremely effective under other conditions of heavy shock loading, particularly on slow oscillating or reciprocating bearings, or applications designed for extended intervals between re-lubrication.\nNLGI 2. Color Black.\nHeavy Duty, Industrial, Passenger Car Automotive", "domain": "chemistry", "round": 3} +{"url": "https://www.researchandmarkets.com/reports/2239393/tms_2008_137th_annual_meeting_and_exhibition", "date": "2021-06-17T09:16:25Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-25/segments/1623487629632.54/warc/CC-MAIN-20210617072023-20210617102023-00515.warc.gz", "language_score": 0.7188103199005127, "token_count": 4035, "dump": "CC-MAIN-2021-25", "global_id": "webtext-fineweb__CC-MAIN-2021-25__0__21939374", "lang": "en", "text": "2008 Nanomaterials –– Fabrication, Properties, and Applications.\nEffect of Nb and Sn on the Transformation of a to ß–Ti in Ti–35 Nb–2.5 Sn Nanostructure Alloy Using Mechanical Alloying (A. Omran, K. Woo, D. Kim, S. Kim, D. Zhang, and N. Barakat).\nNano–Diamond Coatings for Machining Applications (J. Hu, K. Chou, and R. Thompson).\nNanowires of AlN and Si3N4 Prepared from Amorphous Powders (Z. Han, M. Lü, M. Yang, and H. Zhu).\nStructural Identification of Nanocrystals in the Transmission Electron Microscopy (P. Moeck).\nStudy on Nano–Alumina Prepared by Low–Temperature Combustion Synthesis (R. Guo, J. Wang, and X. Zhai).\nSynthesis and Characterization of Nano–Spinel Lithium Manganate (X. Xie, S. Yan, H. Zhou, W. Huang, W. Luo, and X. Li).\nTemperature and High Energy Si Ions Bombardment Effects on the Thermoelectric Properties of GdFe4Sb6–yGey Thin Films (S. Guner, S. Budak, C. Muntele, and D. Ila).\nThermoelectric Generator from Sequentially Deposited SiO2/Gd0.1Fe4Sb0.1Ge4.23 Nanolayers Modified by MeV Si Ions Bombardment (S. Guner, S. Budak, C. Muntele, and D. Ila).\nAtomic Layer Deposited Thin Films and Their Applications (H. Jeon).\nThe Usage of Nano–Structure for Direct Harvesting of the Nuclear Particles Energy as Electricity (L. Popa–Simil, and C. Muntele).\nContinuous Manufacturing and Novel Coating Technologies of Photocataylytic Nanoparticles (C. Wögerer, N. Stelzer, and H. Noll).\nElectron–Phonon Interaction in Nanodevices (K. Král).\nDamping of Hybrid surface Plasmon Modes in Ag Nanoparticles; Application to Vapor Sensing (S. Karumuri, and K. Kalkan).\nElectrophoretic Phenomena of Fine Particles in Aqueous and Non–Aqueous Solvents (J. Shibata, D. Yamashita, M. Tateyama, and N. Murayama).\nPosition Controlled Fabrication of Metal Nanostructures with Focused Electron Beam (K. Furuya, M. Takeguchi, M. Song, K. Mitsuishi, and M. Tanaka).\nPhase Field Modeling of Nanscale Island Dynamics (Z. Hu, S. Li, J. Lowengrub, S. Wise, and A. Voigt).\nTemperature, Thickness and MeV Si Ions Bombardment Effects on the Thermoelectric Generator from Er0.1Fe1.9SbGe0.4 Thin Film (S. Budak, S. Guner, C. Muntele, and D. Ila).\nSynthesis of 1–D Nanostructures of Trititanate Thin Films on a Titanium Metal Flake (S. Kim, Y. Guo, N. Lee, H. Oh, K. Park, S. Jeong, and S. Kim).\nSonochemical Synthesis of Nanostructured Anatase and Kinetics of Phase Transformation and Coarsening at Different Heat Treatment Conditions (L. Gonzalez–Reyes, I. Hernández–Pérez, H. Dorantes Rosales, E. Arce Estrada, and F. Robles Hernández).\nFabrication of Hexagonal Barium Ferrite Nanoparticles by Carbon Combustion Synthesis (K. Martirosyan, Y. Wang, L. Chang, D. Luss, and D. Litvinov).\nChemical Synthesis and Magnetic Properties of Cubic Morphology Fe3Pt Nanoparticles (M. Mandal, M. Shamsuzzoha, and D. Nikles).\nGrain Growth Behavior and Consolidation of Ball Milled Nanocrystalline Iron–Chromium Alloys (R. Gupta, R. Singh, and C. Koch).\nSpecific Heat and Thermal Conductivity Measurements Parallel and Perpendicular to the Long–Axis of Cobalt Nanowires (N. Pradhan, H. Duan, J.. Liang, and G. Iannacchione).\nStructure and Hardness Evolution in Nanocrystalline LIGA Fabricated Ni–6.7at%W Alloy at 873 K (A. Haseeb, and K. Bade).\nUltrafine–Grained Materials: Fifth International Symposium.\nIntrinsic Microstrain in Nanocrystalline Metals (J. Markmann, V. Yamakov, A. Stukowski, K. Albe, and J. Weissmüller).\nThe Effect of Grain Size on the Property of Magnesium Alloy AZ31 (J. Wang, D. Yin, J. Liu, J. Tao, and Y. Su).\nApplication of ECAP for Ferritic Stainless Steel Sheets to Control Texutre and Alleviate Ridging (H. Miyamoto, N. Jinbo, M. Hatano, and T. Mimaki).\nMechanical Properties of Ultra Fine Grained Aluminum and Iron Produced by Accumulative Roll Bonding Method (S. Tamimi, M. Ketabchi, and N. Parvin).\nMicrostructure of a FeCoV Alloy Processed by Equal Channel Angular Pressing (Z. Du, J. Wang, Q. Wang, and H. Fu).\nMicrostructure Refinement of Ti–6Al–4V during Warm Deformation (S. Zherebtsov, M. Murzinova, S. Mironov, G. Salishchev, and L. Semiatin).\nStored Energy and Recrystallization Temperature of High Purity Copper after Equal Channel Angular Pressing (Y. Zhang, J. Wang, C. Cheng, and J. Liu).\nHume–Rothery Symposium – Nanoscale Phases (Invited Only).\nEmployment of Oriental Philosophy in the Establishment of Framework for Probing Nanoscale Science and Technology (J. Duh, and C. Peng).\nAlloying Events in Three–Layer Au/Pd Nanoparticles (D. Ferrer, and M. Jose–Yacaman).\nStructures and Properties of ZnO/SnO2–Cosubstituted In2O3 Films (M. Zhang, S. Xie, D. Buchholz, and R. Chang).\nGrain Size Refinements in Al–Mg and Cu–Mg Alloys by Hydrogen Heat Treatment (A. Kamegawa, and M. Okada).\nApplication of Microscopy to Nanoscale Organic Materials (S. Isoda, and H. Kurata).\nAn EDX–Based Oxidation Test for Evaluating Cu Out–Diffusion in Pre–Plated Cu–Alloy Leadframes (L. Liu, and T. Zhang).\nEnhancing Materials Durability via Surface Engineering\nFatigue Design Diagram (FDD) Code to Design Compressive Residual Stresses to Improve Performance of Damage–Limited Components and Structures (N. Jayaraman, P. Prevey, R. Ravindranath, and M. Shepard).\nA Functionally Graded Design Study for Boron Carbide and Boron Carbonitride Thin Films Deposited by Plasma–Enhanced DC Magnetron Sputtering (T.Tavsanoglu, O. Yucel, O. Addemir, and M. Jeandin).\nReduced Wear and Friction Losses by DLC Coating of Piston Pins (R. Morgenstern, W. Kießling, and S. Reichstein).\nGrain Boundary Engineering of Superalloys for Aerospace Engine Applications (P. Lin, V. Provenzano, R. Heard, H. Miller, and G. Palumbo).\nDiffusion Alloying of Thin Stainless Steel Foils by Simultaneous Addition of Al and Reactive Elements (D. Pilone, F. Felli, and U. Bernabai).\nCold Roll Bonding and Annealing Process to Produce an Intermetallic Layer on Ti Substrate (D. Pilone, and F. Felli).\nMinerals, Metals and Materials under Pressure.\nQuantum–Based Atomistic Simulation of Metals at Extreme Conditions (J. Moriarty, J. Glosli, R. Hood, J. Klepeis, D. Orlikowski, P. Söderlind, and L. Yang).\nEffects of Microstructure on Spall Damage Localization in Shock Loaded Copper Multicrystals (S. Hashemian, S. Digiacomo, P. Peralta, H. D Armas, S. Luo, E. Loomis, D. Paisley, D. Byler, R. Dickerson, and K. McCllelan).\nMicrostructural Modifications after Small Charge Explosions in Aluminum and Copper Targets (D. Firrao, P. Matteis, C. Pozzi, G. Scavino, G. Ubertalli, M. Ienco, G. Pellati, P. Piccardo, M. Pinasco, G. Costanza, R. Montanari, M. Tata, G. Brandimarte, and S. Petralia).\nDirect Density Measurements Using Plate Impact and Proton Radiography (P. Rigg, C. Scwartz, R. Hixson, A. Saunders, F. Merrill, and C. Morris).\nMicro–Structural Response of DP 600 to High Strain Rate Deformation (B. Hamburg, J. Schneider, and S. Jones).\nShear Strength and Texture Evolution in Tantalum Foils (J. Escobedo, D. Field, and D. Lassila).\nMechanical Behavior, Microstructure, and Modeling of Ti and Its Alloys\nDesign of Highly Formable and Strong Titanium Alloys through Plasticity Induced Transformation (S. Neelakantan, P. Rivera–Díaz–del–Castillo, and S. van der Zwaag).\nPowder Metallurgy Processes for Producing Titanium Alloy Products from Hydrogenated Titanium Powder (J. Adams, V. Duz, and V. Moxson).\nInteraction between NiTi SMA and Graphite Mold in Unidirectional Solidification Process (M. Zhu, L. Wang, C. Li, Q. Zhai, and X. Mao).\nViscosity of Slags for High Titanium Ferroalloy by Vacuum Refining (L. Jiao, T. Zhang, J. Yao, and J. Yao).\nDeoxidization Mechanism of In–Situ Electro–Deoxidization of TiO2 to Titanium (X. Zhai, Z. Zhang, J. Li, and M. Zhang).\nInvestigating Macrozones in Titanium Billet using Electron Backscattered Diffraction (B. Wynne, P. Davies, and M. Rainforth).\nResearch on Inclusion in High Titanium Ferroalloy (L. Jiao, T. Zhang, J. Yao, and C. Xing).\nEffect of Oxygen on Fracture Toughness and Stress–Corrosion Cracking of Ti–6211 (P. Pao, M. Imam, H. Jones, R. Bayles, and J. Feng).\nThe Effect of Thermal Oxidation on the Fatigue Behavior of Ti6Al4V and Ti6Al7Nb Alloys (O. Meydanoglu, M. Cingi, M. Baydogan, H. Cimenoglu, and E. Kayali).\nMicrostructural and Mechanical Behavior Characterization of Ultrasonically Consolidated Titanium Aluminum Laminates (T. Sano, J. Catalano, D. Casem, and D. Dandekar).\nThe Effect of Processing Parameters on Biocompatibility of Micro–Arc Oxidized Titanium Alloys (M. Gunyuz, M. Baydogan, H. Cimenoglu, and E. Kayali).\nA Constitutive Model of Cavitation–Induced Damage in Ti Alloys (S. Keralavarma, and A. Benzerga).\nRefractory Metals 2008\nAnomalous Strain–Rate Dependence of Ductility in a Fully Recrystallized 50Mo–50Re Alloy at Room Temperature (J. Xu, M. Effgen, and T. Zhai).\nFirst Principles Design of Ductile Refractory Alloys (M. Gao, A. Rollett, M. Widom, O. Dogan, and P. King).\nInfluence of Microstructure on the Fracture Toughness of Tungsten Alloys (B. Gludovatz, M. Faleschini, S. Wurster, A. Hoffmann, and R. Pippan).\nOxidation Behavior of Alloys from the Nb–W–Cr System Containing C Modifiers (M. Gonzalez, and S. Varma).\nMechanics and Kinetics of Interfaces in Multi–Component Materials Systems\nSummary of Interface Effects on Fracture and Fatigue of Laminated Aluminum Composites (H. Hassan, and J. Lewandowski).\nEvaluation of Variability on the Thermomechanical Response of Nitride Nuclear Fuels through Microstructurally Explicit Models (M. Garcia, S. Park, K. Wheeler, P. Peralta, and K. McClellan).\nA Study of Interfacial Growth Kinetics and Mechanics for an Fe Fibre Reinforced Al Alloy (S. Kenningley, S. Barnes, and P. Withers).\nComplex Oxide Materials – Synthesis, Properties and Applications.\nNanostructures in Thin Films of ZnO (H. Bahadur, A. Sr.ivastava, Rashmi, and S. Chandra).\nApplication of High–e Ceramics for Enhanced Sensitivity of Electron Paramagnetic Resonance Spectrometer (I. Geifman, I. Golovina, and A. Belous).\nCharacterization of Anatase Synthesized by Sonochemical Means and Effects of Heat Treatments (L. Gonzalez–Reyes, I. Hernández–Pérez, H. Dorantes Rosales, E. Arce–Estrada, and F. Robles Hernández).\nCurrent Density Influences on Morphology and Adhesion of RuO2 - nH2O Films Electrodeposited on Tantalum Substrate (W. Gan, Z. Qin, H. Liu, and X. Shi).\nStudy of the Superficial Behavior of Inorganic Pigments (Iron Oxides) (F. Vásquez Jiménez, O. Restrepo Baena, and M. Bustamante Rúa).\nStudy on Structure and Properties of Glass Ceramics from Converter Slag (J. Mao–fa, Z. Da–yong, and S. Pei–yang).\nSynthesis of Superconductor Oxide Ceramics by Combustion of Carbon Nanoparticles (K. Martirosyan, E. Galstyan, Y. Xue, and D. Luss).\nMaterials in Clean Power Systems III: Fuel Cells, Hydrogen–, and Clean Coal–Based Technologies\nCarbon Dioxide–Selective Membranes for Hydrogen Purification and Carbon Dioxide Capture (H. Bai, and W. Ho).\nCritical Material and Process Issues for CO2 Separation from Coal–Powered Plants (W. Liu, D. King, J. Liu, B. Johnson, Y. Wang, and G. Wang).\nCeramic Coatings for Metallic SOFC Interconnects (J. Fergus).\nNovel Coatings for Stainless Steel Interconnects Utilized in SOFCs (W. Wei, N. Shaigan, W. Chen, D. Ivey, A. Wood, and S. Benhaddad).\nInvestigation of Thin Film Mn–Co–Fe Spinel Oxide Coatings Deposited by RF–Magnetron Sputtering on Metallic Interconnects for SOFC Applications (C. Mardare, M. Spiegel, A. Savan, and A. Ludwig).\nEffects of Cell Operating Conditions on Degradation by Chromium (T. Cruse, B. Ingram, M. Krumpelt, S. Wang, and P. Salvador).\nThe Operating Characteristics of Diesel–Driven SOFC (I. Kang, Y. Kang, S. Yoon, G. Bae, and J. Bae).\nStudy on the Preparation of Dendritic Zinc Powder for Zinc–Air Battery by Electrodeposition (Q. Tian, X. Guo, D. Li, and J. Li).\nCoherent Carbon–Cryogel–Ammonia–Borane Nanocomposites for H2 Storage (S. Spehri, A. Feaver, T. Autrey, and G. Cao).\nThe 50 K Anomoly in the Shear Modulus of ß–PdH0.71 (D. Safarik, and R. Schwarz).\nEffects of Partial Substitution of Al for Mg on the Electrode Properties of Mg2Ni Thin Film (J. Xu, Y. Li, and F. Wang).\nEmerging Interconnect and Packaging Technologies\nWetting Kinetics of Eutectic Lead and Lead–Free Solders: Spreading over Cu Surface (H. Zhao, D. Reddy Nalagatla, and D. Sekulic).\nMechanical Properties of Lead–Free Solder Joints – the Size Effect (P. Zimprich, U. Saeed, B. Weiss, and H. Ipser).\nMicrostructure, Defects, and Reliability of Mixed Pb Free/SnPb Assemblies (P. Snugovsky, H. McCormick, S. Bagheri, Z. Bagheri, C. Hamilton, and M. Romansky).\nCharacterization of Tungsten Carbide Electrical Contacts for High–Temperature Electronics (L. Wilkinson, C. Muntele, S. Budak, and D. Ila).", "domain": "chemistry", "round": 3} +{"url": "https://pubmed.ncbi.nlm.nih.gov/25200870/", "date": "2023-02-04T07:08:37Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-06/segments/1674764500094.26/warc/CC-MAIN-20230204044030-20230204074030-00809.warc.gz", "language_score": 0.9132411479949951, "token_count": 532, "dump": "CC-MAIN-2023-06", "global_id": "webtext-fineweb__CC-MAIN-2023-06__0__274340372", "lang": "en", "text": "The organic anion-transporting polypeptide (OATP) 1B3 is a membrane transport protein that mediates hepatic uptake of many drugs and endogenous compounds. Currently, determination of OATP-mediated drug-drug interactions in vitro is focused primarily on direct substrate inhibition. Indirect inhibition of OATP1B3 activity is under-appreciated. OATP1B3 has putative protein kinase C (PKC) phosphorylation sites. Studies were designed to determine the effect of PKC activation on OATP1B3-mediated transport in human hepatocytes using cholecystokinin-8 (CCK-8), a specific OATP1B3 substrate, as the probe. A PKC activator, phorbol-12-myristate-13-acetate (PMA), did not directly inhibit [(3)H]CCK-8 accumulation in human sandwich-cultured hepatocytes (SCH). However, pretreatment with PMA for as little as 10 minutes rapidly decreased [(3)H]CCK-8 accumulation. Treatment with a PKC inhibitor bisindolylmaleimide (BIM) I prior to PMA treatment blocked the inhibitory effect of PMA, indicating PKC activation is essential for downregulating OATP1B3 activity. PMA pretreatment did not affect OATP1B3 mRNA or total protein levels. To determine the mechanism(s) underlying the indirect inhibition of OATP1B3 activity upon PKC activation, adenoviral vectors expressing FLAG-Myc-tagged OATP1B3 (Ad-OATP1B3) were transduced into human hepatocytes; surface expression and phosphorylation of OATP1B3 were determined by biotinylation and by an anti-phosphor-Ser/Thr/Tyr antibody, respectively. PMA pretreatment markedly increased OATP1B3 phosphorylation without affecting surface or total OATP1B3 protein levels. In conclusion, PKC activation rapidly decreases OATP1B3 transport activity by post-translational regulation of OATP1B3. These studies elucidate a novel indirect inhibitory mechanism affecting hepatic uptake mediated by OATP1B3, and provide new insights into predicting OATP-mediated drug interactions between OATP substrates and kinase modulator drugs/endogenous compounds.\nCopyright © 2014 by The American Society for Pharmacology and Experimental Therapeutics.", "domain": "chemistry", "round": 3} +{"url": "https://www.ledtorchshop.com.au/product/keeppower-10a-discharge-inr-21700-5000mah-rechargeable-battery-unprotected-nh2150/", "date": "2023-12-06T17:57:40Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100602.36/warc/CC-MAIN-20231206162528-20231206192528-00165.warc.gz", "language_score": 0.8211353421211243, "token_count": 415, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__259666800", "lang": "en", "text": "- Type: Quality High Drain Li-ion Rechargeable Battery\n- Maximum Size: （D）21.4*（L）74mm\n- Nominal Voltage: 3.7V\n- Nominal Capacity: 5000mAh\n- Continuous Maximum Discharge Current: 10A\n- Weight: 71.0g\n- High Drain 21700 Li-ion Rechargeable Battery\n- Minimum Capacity: 4900mAh\n- Typical Capacity: 5000mAh\n- Normal Voltage: 3.7V\n- Standard Continuous Charging Current: 2450mA\n- Maximum Continuous Charging Current: 4900mA\n- Maximum Continuous Discharging Current: 10A\n- Maximum Pulse Discharging Current: 15A\n- 4.2V full charged voltage and 2.5V discharge cut off voltage\n- High charge and discharge currents reduce cycle life\nPlease note that Lithium-ion batteries can leak, cause fires, or explode when misused or when defective.\nFor your own safety, you must read these instructions and warnings before using or charging a Lithium-ion battery.\n● Please fully charge before first use.\n● Use only high quality chargers specifically designed for Lithium-ion batteries.\n● A Lithium-ion battery should NEVER be discharged below 2.5V.\n● NEVER exceed a battery’s maximum continuous discharge rating.\n● DO NOT short-circuit the battery, keep it away from loose change and metal objects.\n● DO NOT use a battery if there is abnormal smell, heat, deformities, or discolouration.\n● DO NOT crush, hit, impact or disassemble a battery.\n● DO NOT dispose of in fire, near fire or high temperature.(more than 60℃/140℉)\n● DO NOT expose in liquid such as water, seawater and soda.\n● If the electrolyte goes into eyes, please wash eyes with clean water immediately and go for a medical treatment.", "domain": "chemistry", "round": 3} +{"url": "https://themeaningofwater.com/2015/02/19/2-6-billion-year-old-fresh-water-on-earth-points-to-life-on-mars/", "date": "2023-02-08T16:02:01Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-06/segments/1674764500837.65/warc/CC-MAIN-20230208155417-20230208185417-00722.warc.gz", "language_score": 0.946605920791626, "token_count": 798, "dump": "CC-MAIN-2023-06", "global_id": "webtext-fineweb__CC-MAIN-2023-06__0__133545637", "lang": "en", "text": "Barbara Sherwood Lollar, geologist at the University of Toronto, crouches over a bubbling upwelling of very clear water from a fracture on the floor of a 3 km deep mine in the Canadian Precambrian Shield near Timmins, Ontario. She dips her finger in the pool and brings it to her mouth for a taste. “Very salty,” she says. “much saltier than seawater.”\nIt turns out that the saltier the water, the older it is likely to be. The taste test is the first step to further analysis that uses oxygen and hydrogen in the water molecule, as well as noble gases such as helium, neon, argon and xenon, and presence of certain isotopes created early in Earth’s history through interactions with the surrounding radioactive rock. Analysis reveals that the hydrogen-rich water Sherwood Lollar tasted is between 1.5 and 2.6 billion years old—as old as the rocks themselves. The hydrogen- and methane-rich water may provide energy for microbes like those found around hydrothermal vents in the deep ocean. “When these rocks formed,” Sherwood Lollar shares, “this part of Canada was the ocean floor.”\nGeologists have known since the 1880s about the presence of deep salty ancient water in continental crust—locked in microscopic voids in minerals, pore spaces between minerals, and veins and fractures in rock—in Canada, Finland and South Africa. The question had been: is that water part of current circulation with surface water or does it retain old chemistry, structure and potential biota? These new findings, reported in the journal Nature in May 2013, provide evidence that ancient pockets of water have remained isolated in the Earth’s crust for billions of years.\nThis ancient water provides an “energy that can support life without sunlight,” says Lollar. Instead, the microbes would subsist on chemicals created through the interactions between water and rock. A decade earlier in a South African gold mine some 2.8 km below the surface, Lollar and others discovered sulfate-reducing microbial communities in saline fracture waters. The microbes survived, cut off from the sun for tens of millions of years.\nTwo chemical reactions combine to produce high quantities of hygrogen—the most common substance in the universe—and doubling estimates of global production from these processes. Previous estimates had been based on hydrogen production from the ocean floor. “This represents a quantum change in our understanding of the total volume of Earth’s crust that may be habitable,” said Sherwood Lollar.\nEstimates had not previously included contributions from the ancient continents such as Precambrian rocks, which comprise more than 70% of the surface of the Earth’s crust. This is a huge source of possible energy for life and has important implications for the search for deep microbial life and for astrobiology.\nLarge areas on Mars resemble the Earth’s Precambrian Shield, with billions of years-old rocks of similar mineralogy. If the ancient rocks of Earth are producing this much hydrogen, similar processes may be occurring on Mars, said Sherwood Lollar.\n“Life that formed could have found its way into similar pockets of water in the Martian crust,” Chris Ballentine, geochemist at the University of Manchester, said. “These pockets of water can survive and provide a place for life to have survived long after the surface of Mars lost its water and became sterile.”\nNina Munteanu is an ecologist, limnologist and internationally published author of award-nominated speculative novels, short stories and non-fiction. She is co-editor of Europa SF and currently teaches writing courses at George Brown College and the University of Toronto. Visit www.ninamunteanu.ca for the latest on her books.", "domain": "chemistry", "round": 3} +{"url": "https://link.springer.com/article/10.1007/s10265-015-0710-2", "date": "2019-04-21T21:01:22Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-18/segments/1555578532882.36/warc/CC-MAIN-20190421195929-20190421221929-00449.warc.gz", "language_score": 0.7480905652046204, "token_count": 951, "dump": "CC-MAIN-2019-18", "global_id": "webtext-fineweb__CC-MAIN-2019-18__0__54620856", "lang": "en", "text": "Identification of Arabidopsis thaliana NRT1/PTR FAMILY (NPF) proteins capable of transporting plant hormones\n- 3.2k Downloads\nNRT1/PTR FAMILY (NPF) proteins were originally identified as nitrate or di/tri-peptide transporters. Recent studies revealed that this transporter family also transports the plant hormones auxin (indole-3-acetic acid), abscisic acid (ABA), and gibberellin (GA), as well as secondary metabolites (glucosinolates). We developed modified yeast two-hybrid systems with receptor complexes for GA and jasmonoyl-isoleucine (JA-Ile), to detect GA and JA-Ile transport activities of proteins expressed in the yeast cells. Using these GA and JA-Ile systems as well as the ABA system that we had introduced previously, we determined the capacities of Arabidopsis NPFs to transport these hormones. Several NPFs induced the formation of receptor complexes under relatively low hormone concentrations. Hormone transport activities were confirmed for some NPFs by direct analysis of hormone uptake of yeast cells by liquid chromatography–tandem mass spectrometry. Our results suggest that at least some NPFs could function as hormone transporters.\nKeywordsAbscisic acid (ABA) Arabidopsis (Arabidopsis thaliana) Gibberellin (GA) Jasmonoyl-isoleucine (JA-Ile) NRT1/PTR FAMILY (NPF) Transport\nThis work was supported in part by the Japan Society of Promotion of Science (JSPS) KAKENHI [Challenging Exploratory Research (24657040) to M.S.].\n- Endo A, Sawada Y, Takahashi H, Okamoto M, Ikegami K, Koiwai H, Seo M, Toyomasu T, Mitsuhashi W, Shinozaki K, Nakazono M, Kamiya Y, Koshiba T, Nambara E (2008) Drought induction of Arabidopsis 9-cis-epoxycarotenoid dioxygenase occurs in vascular parenchyma cells. Plant Physiol 147:1984–1993PubMedCentralPubMedCrossRefGoogle Scholar\n- Jikumaru Y, Asami T, Seto H, Yoshida S, Yokoyama T, Obara N, Hasegawa M, Kodama O, Nishiyama M, Okada K, Nojiri H, Yamane H (2004) Preparation and biological activity of molecular probes to identify and analyze jasmonic acid-binding proteins. Biosci Biotechnol Biochem 68:1461–1466PubMedCrossRefGoogle Scholar\n- Krouk G, Lacombe B, Bielach A, Perrine-Walker F, Malinska K, Mounier E, Hoyerova K, Tillard P, Leon S, Ljung K, Zazimalova E, Benkova E, Nacry P, Gojon A (2010) Nitrate-regulated auxin transport by NRT1.1 defines a mechanism for nutrient sensing in plants. Dev Cell 18:927–937PubMedCrossRefGoogle Scholar\n- Leran S, Varala K, Boyer JC, Chiurazzi M, Crawford N, Daniel-Vedele F, David L, Dickstein R, Fernandez E, Forde B, Gassmann W, Geiger D, Gojon A, Gong JM, Halkier BA, Harris JM, Hedrich R, Limami AM, Rentsch D, Seo M, Tsay YF, Zhang M, Coruzzi G, Lacombe B (2014) A unified nomenclature of NITRATE TRANSPORTER 1/PEPTIDE TRANSPORTER family members in plants. Trends Plant Sci 19:5–9PubMedCrossRefGoogle Scholar\n- Li JY, Fu YL, Pike SM, Bao J, Tian W, Zhang Y, Chen CZ, Li HM, Huang J, Li LG, Schroeder JI, Gassmann W, Gong JM (2010) The Arabidopsis nitrate transporter NRT1.8 functions in nitrate removal from the xylem sap and mediates cadmium tolerance. Plant Cell 22:1633–1646PubMedCentralPubMedCrossRefGoogle Scholar", "domain": "chemistry", "round": 3} +{"url": "https://studylib.net/doc/6972182/microsoft-word---rh---stanford-advanced-materials", "date": "2023-06-05T06:54:06Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-23/segments/1685224651325.38/warc/CC-MAIN-20230605053432-20230605083432-00677.warc.gz", "language_score": 0.8110239505767822, "token_count": 652, "dump": "CC-MAIN-2023-23", "global_id": "webtext-fineweb__CC-MAIN-2023-23__0__90491389", "lang": "en", "text": "Current Version: 2.0 Revision Date: Sep 5, 2012 Material Safety Data Sheet Identity: Rhodium Formula: Rh SECTION I - GENERAL INFORMATION Manufacturer: Stanford Advanced Materials (SAM) The information below is believed to be accurate and represents the best information available to SAM. However, SAM makes no warranty, expressed or implied with respect to such information and we assume no liability resulting from its use. SECTION II - PRODUCT INFORMATION/HAZARDOUS INGREDIENTS CAS # 7440-16-6 Concentration % 100 TVL (Units): 1.0mg/M3 SECTION III - PHYSICAL/ CHEMICAL CHARACTERISTICS Specific Gravity 12.44 Melting Point: 1966° C Solubility in water: Insoluble Physical Form: Gray Powder SECTION IV - FIRE AND EXPLOSION DATA Flammability: No Flash Point: N/A Means of Extinction: Co2, Foam, Dry chemical, Use self-contained breathing apparatus. Unusual Fire and Explosion Hazards: May emit toxic fumes upon decomposition. SECTION V - REACTIVITY DATA Stability: Yes Conditions to Avoid – Extreme heat Incompatibility - Materials to avoid: Organic solvents, flammable liquids. Hazardous Decomposition Products: Rh2O3 Hazardous Polymerization: Will not occur. SECTION VI - HEALTH HAZARD DATA Emergency And First Aid Procedures: In case of eye contact, flush eyes with lukewarm water for 15 minutes, seek medical attention. In case of skin contact, brush material off skin. Wash affected area with soap and water, seek medical attention. In case of inhalation, remove victim to fresh air, administer oxygen if breathing is difficult, seek medical attention. In case of ingestion, seek medical attention. SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE. Steps To Be Taken In Case Material Is Released or Spilled: Wear appropriate respiratory and protective equipment specified in Section VIII-control measures. Isolate spill area and provide ventilation. Vacuum up spill using a high efficiency particulate absolute (HEPA) air filter and place in a closed container for proper disposal. Take care not to raise dust. Waste Disposal Method: Dispose of in accordance with local, state and federal regulations. Hazard Label Information: Store in cool, dry area - Store in tightly sealed container. Wash thoroughly after handling SECTION VIII - CONTROL MEASURES Protective Equipment Summary - Hazard Label Information NIOSH approved respirator Impervious gloves Safety glasses Clothes to prevent skin contact Respiratory Protection (Specify Type): Ventilation: Local Exhaust: Local exhaust ventilation may be necessary to control any air contaminants to within their PEL or TLVs during the use of this product. Special: None Mechanical (GEN): Good general ventilation is recommended. Other Protective Clothing or Equipment: Protective gear suitable to prevent contamination Work/Hygienic/Maintenance Practices: Implement engineering and work practice controls to reduce and maintain concentration of exposure at low levels. Use good housekeeping and sanitation practices. Do not use tobacco or food in work area. Wash thoroughly before eating and smoking. Do not blow dust off clothing or skin with compressed air.", "domain": "chemistry", "round": 3} +{"url": "http://eduface.eu/is-online-prescription-for-clonazepam-valid/rivotril-clonazepam-dosage-dose-of-color.php", "date": "2018-06-22T16:44:59Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-26/segments/1529267864740.48/warc/CC-MAIN-20180622162604-20180622182604-00293.warc.gz", "language_score": 0.8576165437698364, "token_count": 289, "dump": "CC-MAIN-2018-26", "global_id": "webtext-fineweb__CC-MAIN-2018-26__0__17934771", "lang": "en", "text": "Jun 2, - SAP Relevant identified uses of the substance or mixture and uses advised against repeated, because of the half-life of elimination of Clonazepam is much higher Information on basic physical and chemical properties. Colour orange initial therapeutic dose: 1 to 2 mg/d (adults). *1. The initial dose for adults with seizure disorders should not exceed mg/day divided into three doses. Dosage may be increased in increments of to 1 mg Missing: color. Brand name: Rivotril Oral liquid; Active ingredient: Clonazepam; Schedule: S4 The risks are greater for patients on higher doses or on long term treatment. DOSE OF COLORS Liquid Lipstick Swatches!! The efficacy of Klonopin was established dosage two 6- to 9-week trials dose panic disorder dose whose diagnoses corresponded to the DSM-IIIR rivotril of panic disorder see Clinical Trials. Respiratory Depression Klonopin may cause respiratory depression and should be used with caution in patients with compromised respiratory function e. Physicians are advised dosage discuss the following issues with patients for clonazepam they prescribe Klonopin: Rivotril is no evidence teva clonazepam 2mg para que clonazepam induces its own metabolism or that of other drugs in humans. Clonazepam The initial color for color with seizure disorders should not exceed 1.", "domain": "chemistry", "round": 3} +{"url": "https://wholisticmatters.com/herb-detail/sweet-flag/", "date": "2023-12-02T08:36:43Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100381.14/warc/CC-MAIN-20231202073445-20231202103445-00480.warc.gz", "language_score": 0.8165298104286194, "token_count": 469, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__142480746", "lang": "en", "text": "Scientific Name: Acorus calamus\n- Volatile oils (sequiterpenes and monoterpenes: acorenone, isocalamendiol, α-and β-asarone (content varies greatly with species and habitat), α-and β-pinenes, myrcene, p-cymene, phellandrene-β, terpinene-γ, terpinolene, thujane and limonene.\n- Saponins (steroidal glycosides)\n- Bitter principle (acorin, acoretin)\n- Lignans (epieudesmin, galgravin)\n- Anthelmintic (Antiparasitic)\n- Antimicrobial (Antifungal & Antibacterial)\n- Expectorant (Bronchodilator)\n- Nervine stimulant\nMechanism of Action & Pharmacology:\n- Volatile oils affect the digestive, circulatory, nervous, and respiratory systems. Anticholinergic activity, calcium channel blockade, and phosphodiesterase inhibition (specifically PDE4) may provide possible pharmacological basis for use in the relaxation of airways and in conditions such as asthma.\n- Mucilage & saponins increase expectoration and are theorized to act as a relaxant and antispasmodic to the lungs from the digestive tract through the spinal reflex.\n- Decoction in water or milk, honey often added\n- Topical: as paste or plaster\nSafety & Toxicity Concerns:\n- Not for long-term use.\n- Large doses may cause nausea and/or vomiting and tachycardia.\n- Avoid during pregnancy due to possible emmenagogue effects.\n- Use caution in immunocompromised individuals.\n- Note: Much of research on the pharmacology of A. calamus centers on the VO asarone which is considered carcinogenic. However, the American variety of the species does not appear to include asarone in meaningful amounts, instead having sesquiterpenes as part of its volatile oil composition and is thus considered safer to use.\n- Theoretical additive effects with immunosuppressant, hypotensive or hypoglycemic agents.", "domain": "chemistry", "round": 3} +{"url": "https://www.borderless.net/news/chemical-value-chain/sadara-loss-widens-as-start-up-of-20-billion-complex-continues/", "date": "2022-09-28T22:56:10Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-40/segments/1664030335286.15/warc/CC-MAIN-20220928212030-20220929002030-00018.warc.gz", "language_score": 0.9304248690605164, "token_count": 803, "dump": "CC-MAIN-2022-40", "global_id": "webtext-fineweb__CC-MAIN-2022-40__0__47900814", "lang": "en", "text": "Sadara, a joint venture between Saudi Aramco and Dow Chemical, today reported a larger second-quarter net loss as the company continues to ramp up operations at the $20 billion petchems complex at Jubail, Saudi Arabia.\nNet loss in the second quarter reached 1.59 billion Saudi riyals ($423.8 million). This compares with a net loss of SR1.49 billion in the year-earlier quarter. Sales revenue in the second quarter was SR1.31 billion compared with SR196million in the second quarter of 2016. Sales in the first half of the year amounted to SR2.17 billion compared with SR294 million in the first half of 2016.\nSadara cites start-up and ramping up costs at the integrated facilities as the main reasons for the increase in second-quarter net loss. The company recently commissioned several of its 26 chemical plants, including a two-train polyols complex with a combined capacity of 400,000 metric tons/year. The company has also recently brought on stream a propylene oxide (PO) complex with capacity of 390,000 metric ton/year PO. Last month it also started commercial production at its amines plant comprising two separate units with combined capacity of 208,000 metric tons/year designed to produce ethanolamines and ethyleneamines.\nEarlier this year, Sadara started up a 70,000-metric ton/year propylene glycol plant, a 200,000-metric tons/year butyl glycol ether unit, and a 400,000-metric tons/year polymeric methylene di-para-phenylene isocyanate (PMDI) complex.\nIn April, Sadara started up its fourth and final polyethylene (PE) unit, the 350,000 metric tons/year low-density polyethylene (LDPE) train. The facility joined two identical 375,000-metric tons/year solution-process linear LDPE plants, able to produce LLDPE and/or high-density PE, and an elastomers train, which came onstream earlier. All four trains are based on Dow’s technology, including its solution LLDPE process. The polyolefin elastomers facility, producing a very low-density form of PE and the first such plant in Saudi Arabia, is designed to produce either 220,000 metric tons/year when using metallocene, or 250,000 metric tons/year when based on Ziegler Natta catalysts. The units receive their feedstock from aTechnip-process mixed-feed cracker, designed to produce 1.5 million metric tons/year of ethylene and 400,000 metric tons/year propylene, which was commissioned last year.\nBy Natasha Alperowicz\nSource: Chemical Week\nFrance has launched an offshore green hydrogen production platform at the country’s Port of Saint-Nazaire this week, along with its first offshore wind farm. The hydrogen plant, which its operators say is the world’s first facility of its type, coincides with the launch of another “first of its kind” facility in Sweden dedicated to storing hydrogen in an underground lined rock cavern (LRC).\nThe project sets up the Hydrogen Valley in Rome, the first industrial-scale technological hub for the development of the national supply chain for the production, transport, storage and use of hydrogen for the decarbonization of industrial processes and for sustainable mobility.\nAt first glance, hydrogen seems to be the perfect solution to our energy needs. It doesn’t produce any carbon dioxide when used. It can store energy for long periods of time. It doesn’t leave behind hazardous waste materials, like nuclear does. And it doesn’t require large swathes of land to be flooded, like hydroelectricity. Seems too good to be true. So…what’s the catch?", "domain": "chemistry", "round": 3} +{"url": "http://www.okbu.edu/academics/sciencemath/faculty/shawna_york.html", "date": "2014-12-20T14:24:41Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2014-52/segments/1418802769894.131/warc/CC-MAIN-20141217075249-00122-ip-10-231-17-201.ec2.internal.warc.gz", "language_score": 0.759453296661377, "token_count": 436, "dump": "CC-MAIN-2014-52", "global_id": "webtext-fineweb__CC-MAIN-2014-52__0__59031071", "lang": "en", "text": "Dr. Shawna York has published and presented a variety of paper topics at the American Chemical Society Regional Meetings for the Southeast and the Southwest regions. In her free time, she volunteers for political activities such as voter turnout drives. She and her husband, Yancy, have two dogs and two cats.\nEducational Background: B.S., Southern Nazarene University M.S., University of Oklahoma Ph.D., University of Oklahoma\nCourses Taught: CHEM 1104, 1114: General Chemistry I, II CHEM 1054, 1063: Introduction to Chemistry I and II CHEM 4114, 4124: Physical Chemistry I and II CHEM 1999: Topic: Problem Solving Skills in General Chemistry II\nSelected Publications and/or Professional Activities: Shawna S. York, M. Buckner, R. Frech, “Ion-Polymer and Ion-Ion Interactions in Linear Poly(ethylenimine) Complexed with LiCF3SO3 and LiSbF6”Macromolecules; 2004; 37(3); 994-999.Shawna York, Scott E. Boesch, R.A. Wheeler, Roger Frech; “Vibrational Assignments of High Molecular Weight Linear Polyethylenimine (LPEI) Based on Monomeric and Tetrameric Model Compounds”; Macromolecules 2003, 36(19), 7348-7351. Shawna S. York, S.E. Boesch, Ralph A. Wheeler, Roger Frech \"Effects of Lithium Triflate and Lithium Bromide on the Vibrational Frequencies of Dimethylethylenediamine\" Phys Chem Comm, (2002). (online journal - http://www.rsc.org ) B.P. Grady, C.P. Rhodes, S. York, R. Frech \"Effects of Temperature on Local Structures in Poly(ethyleneoxide) – Zinc Bromide Salt Complexes\" Macromolecules, 34, 8523, (2001).", "domain": "chemistry", "round": 3} +{"url": "https://aiche.confex.com/aiche/2015/webprogram/Paper420124.html", "date": "2023-12-03T18:24:23Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100508.42/warc/CC-MAIN-20231203161435-20231203191435-00592.warc.gz", "language_score": 0.6756172776222229, "token_count": 601, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__236853856", "lang": "en", "text": "1. J. P. K. Seville, R. Clift, The effect of thin liquid layers on fluidisation characteristics. Powder Technol. 37, 117–129 (1984).\n2. M. L. Passos, A. S. Mujumdar, Effect of cohesive forces on fluidized and spouted beds of wet particles. Powder Technol. 110, 222–238 (2000).\n3. S. McDougall, M. Saberian, C. Briens, F. Berruti, E. Chan, Effect of liquid properties on the agglomerating tendency of a wet gas–solid fluidized bed. Powder Technol. 149, 61–67 (2005).\n4. V. S. Sutkar et al., Experimental study of hydrodynamics and thermal behavior of a pseudo-2D spout-fluidized bed with liquid injection. AIChE J. 61, 1146–1159 (2015).\n5. V. S. Sutkar et al., A novel approach to determine wet restitution coefficients through a unified correlation and energy analysis. AIChE J. 61, 769–779 (2015).\n6. S. Heinrich, M. Peglow, M. Ihlow, M. Henneberg, L. Mörl, Analysis of the start-up process in continuous fluidized bed spray granulation by population balance modelling. Chem. Eng. Sci. 57, 4369–4390 (2002).\n7. L. Fries, S. Antonyuk, S. Heinrich, S. Palzer, DEM–CFD modeling of a fluidized bed spray granulator. Chem. Eng. Sci. 66, 2340–2355 (2011).\n8. D. Jain, N. G. Deen, J. A. M. Kuipers, S. Antonyuk, S. Heinrich, Direct numerical simulation of particle impact on thin liquid films using a combined volume of fluid and immersed boundary method. Chem. Eng. Sci. 69, 530–540 (2012).\n9. P. Darabi, K. Pougatch, M. Salcudean, D. Grecov, DEM investigations of fluidized beds in the presence of liquid coating. Powder Technol. 214, 365–374 (2011).\n10. Y. Tsuji, T. Kawaguchi, T. Tanaka, Discrete particle simulation of two-dimensional fluidized bed. Powder Technol. 77, 79–87 (1993).\n11. T. Mikami, H. Kamiya, M. Horio, Numerical simulation of cohesive powder behavior in a fluidized bed. Chem. Eng. Sci. 53, 1927–1940 (1998).\n12. M. Wu, J. G. Khinast, S. Radl, (Barcelona, 2014).", "domain": "chemistry", "round": 3} +{"url": "http://www.genetex.com/Glucagon-antibody-N1C3-2-GTX112806.html", "date": "2017-04-29T23:29:21Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-17/segments/1492917123632.58/warc/CC-MAIN-20170423031203-00303-ip-10-145-167-34.ec2.internal.warc.gz", "language_score": 0.7882124781608582, "token_count": 341, "dump": "CC-MAIN-2017-17", "global_id": "webtext-fineweb__CC-MAIN-2017-17__0__177960560", "lang": "en", "text": "|Product Description||Rabbit polyclonal antibody to Glucagon|\n|Background||The protein encoded by this gene is actually a preproprotein that is cleaved into four distinct mature peptides. One of these, glucagon, is a pancreatic hormone that counteracts the glucose-lowering action of insulin by stimulating glycogenolysis and gluconeogenesis. Glucagon is a ligand for a specific G-protein linked receptor whose signalling pathway controls cell proliferation. Two of the other peptides are secreted from gut endocrine cells and promote nutrient absorption through distinct mechanisms. Finally, the fourth peptide is similar to glicentin, an active enteroglucagon. [provided by RefSeq]|\n|Synonyms||GLP1 antibody, GLP2 antibody, GRPP antibody, GCG antibody, glicentin-related polypeptide antibody, glucagon antibody, glucagon-like peptide 2 antibody, glucagon-like peptide 1 antibody|\n|Immunogen||Full length human Glucagon Recombinant protein.|\n|Predicted Cross Reactivity species Predicted cross-reactivity:|\nPredicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.\nPlease note that we are only able to guarantee products to work in applications and species in which they have been tested.\n|Mouse, Rat, Dog, Pig, Bovine, Guinea pig|\n|Predict Reactivity Note||Mouse (90%), Rat (90%), Dog (93%), Pig (91%), Bovine (91%), Guinea pig (92%)|", "domain": "chemistry", "round": 3} +{"url": "https://research.uni-luebeck.de/de/publications/modulation-of-human-dna-topoisomerase-ii%CE%B1-function-by-interaction", "date": "2023-12-02T05:18:15Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100327.70/warc/CC-MAIN-20231202042052-20231202072052-00026.warc.gz", "language_score": 0.9171254634857178, "token_count": 314, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__31395768", "lang": "en", "text": "Human DNA topoisomerase IIα (topo II), a ubiquitous nuclear enzyme, is essential for normal and neoplastic cellular proliferation and survival. Several common anticancer drugs exert their cytotoxic effects through interaction with topo II. In experimental systems, altered topo II expression has been associated with the appearance of drug resistance. This mechanism, however, does not adequately account for clinical cases of resistance to topo II-directed drugs. Modulation by protein-protein interactions represents one mechanism of topo II regulation that has not been extensively defined. Our laboratory has identified 14-3-3ε as a topo II-interacting protein. In this study, glutathione S-transferase co-precipitation, affinity column chromatography, and immunoprecipitations confirm the authenticity of these interactions. Three assays evaluate the impact of 14-3-3ε on distinct topo II functional properties. Using both a modified alkaline comet assay and a DNA cleavage assay, we demonstrate that 14-3-3ε negatively affects the ability of the chemotherapeutic, etoposide, to trap topo II in cleavable complexes with DNA, thereby preventing DNA strand breaks. By electrophoretic mobility shift assay, this appears to be due to reduced DNA binding activity. The association of topo II with 14-3-3 proteins does not extend to all 14-3-3 isoforms. No protein interaction or disruption of topo II function was observed with 14-3-3σ.", "domain": "chemistry", "round": 3} +{"url": "https://m.scirp.org/papers/18222", "date": "2021-10-28T08:50:49Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-43/segments/1634323588282.80/warc/CC-MAIN-20211028065732-20211028095732-00326.warc.gz", "language_score": 0.6879472136497498, "token_count": 1627, "dump": "CC-MAIN-2021-43", "global_id": "webtext-fineweb__CC-MAIN-2021-43__0__132995071", "lang": "en", "text": "A. S. Ayoub, B. A. McGaw, C. A. Shand and A. J. Mid-wood, “Phytoavailability of Cd and Zn in Soil Estimated by Stableisotope Exchange and Chemical Extraction,” Plant and Soil, Vol. 252, No. 2, 2003, pp. 291-300. doi:10.1023/A:1024785201942\n R. Durand, N. Bellon and B. Jaillard, “Determining the Net Flux of Charge Released by Maize Roots by Directly Measuring Variations of the Alkalinity in the Nutrient Solution,” Plant and Soil, Vol. 229, No. 2, 2001, pp. 305-318. doi:10.1023/A:1004860326936\n M. J. McLaughlin, P. A. Lancaster, P. W. G. Sale, N. C. Uren and K. I. Peverill, “Use of Cation/Anion Exchange Membranes for Multi-Element Testing of Acidic Soils,” Plant and Soil, Vol. 155-156, No. 1, 1993, pp. 223-226. doi:10.1007/BF00025024\n P. Qian, J. J. Schoenau and W. Z. Huang, “Use of Ion Exchange Membranes in Routine Soil Testing,” Communications in Soil Science and Plant Analysis, Vol. 23, No. 15-16, 1992, pp. 1791-1804. doi:10.1080/00103629209368704\n S. Sato and N. B. Comerford, “Assessing Methods for Developing Phosphorous Desorption Isotherms from Soils Using Anion Exchange Membranes,” Plant and Soil, Vol. 279, No. 1-2, 2006, pp. 107-117. doi:10.1007/s11104-005-0437-2\n M. B. Turrion, J. F. Gallardo and M. I. Gonzalez, “Extraction of Soil-Available Phosphate, Nitrate, and Sulphate Ions Using Ion Exchange Menbranes and Determination by Ion Exchange Chromatography,” Communications in Soil Science and Plant Analysis, Vol. 30, No. 7-8, 1999, pp.1137-1152.\n T. Pare, E. G. Gregorich and B. H. Ellert, “Comparison of Soil Nitrate Extracted by Potassium Chloride and Adsorbed on an Anion Exchange Membrane in Situ,” Communications in Soil Science and Plant Analysis, Vol. 26, No. 5-6, 1995, pp. 883-898. doi:10.1080/00103629509369341\n J. F. van Staden and R. E. Taljaard, “Determination of Ammonia in Water and Industrial Effluent Streams with the Indophenol Blue Method Using Sequential Injection Analysis,” Analytica Chimica Acta, Vol. 344, No. 3, 1997, pp. 281-289. doi:10.1016/S0003-2670(96)00523-5\n E. Ballesteros, A. Rios and M. Valcárcel, “Integrated Automatic Determination of Nitrate, Ammonium and Organic Carbon in Soil Samples,” Analyst, Vol. 122, No. 4, 1997, pp. 309-313. doi:10.1039/A607849D\n F. Zhang, J. Niu, W. Zhang, X. Chen, C. Li, L. Yuan and J. Xie, “Potassium Nutrition of Crops under Varied Regimes of Nitrogen Supply,” Plant Soil, Vol. 335. No. 1-2, 2010, pp. 21-34. doi:10.1007/s11104-010-0323-4\n R. Setia, K. N. Sharma, P. Marschner and H. Singh, “Changes in Nitrogen, Phosphorous, and Potassium in a Long-Term Continuous Maize-Wheat Cropping System in India,” Communications in Soil Science and Plant Analysis, Vol. 40, No. 21-22, 2009, pp. 3348-3366. doi:10.1080/00103620903325950\n J. Ryan, S. Garabet, K. Harmsen and A. Rashid, “A Soil and Plant Analysis Manual Adapted for the West Asia and North Africa Region,” International Center for Agricultural Research in the Dry Areas, Aleppo, 1996.\n M. Giese, Y. Z. Gao, S. Lin and H. Brueck, “Nitrogen Availability in a Grazed Semi-Arid Grassland Is Dominated by Seasonal Rainfall,” Plant and Soil, Vol. 340, No. 1-2, 2010, pp.157-167. doi:10.1007/s11104-010-0509-9\n B. van Raij, J. A. Quaggio and N. M. da Silva, “Extraction of Phosphorus, Potassium, Calcium, and Magnesium from Soils by an Ion-Exchange Resin Procedure,” Communications in Soil Science and Plant Analysis, Vol. 17, No. 5, 1986, pp. 547-566. doi:10.1080/00103628609367733\n S. M. Helali, H. Nebli, R. Kaddour, H. Mahmoudi, M. Lachaal and Z. Ouerghi, “Influence of Nitrate—Ammonium Ratio on Growth and Nutrition of Arabidopsis thaliana,” Plant Soil, Vol. 336, No. 1-2, 2010, pp. 65-74. doi:10.1007/s11104-010-0445-8\n M. M. Wander, D. V. McCracken, L. M. Shuman, J. W. Johnson and J. E. Box, “Anion-Exchange Membranes Used to Assess Management Impacts on Soil Nitrate,” Communications in Soil Science and Plant Analysis, Vol. 26, No. 15-16, 1995, pp. 2383-2390.\n P. Nesse, J. Grava and P. R. Bloom, “Correlation of Several Tests for Phosphorous with Resin Extractable Phosphorous for 30 Alkaline Soils,” Communications in Soil Science and Plant Analysis, Vol. 19, No. 6, 1988, pp. 675- 689.\n S. V. Karmarkar, “Quick Ion Chromatographic Determination of Sulfate Alone in Soil Extracts and Natural Waters,” Communications in Soil Science and Plant Analysis, Vol. 27, No. 3-4, 1996, pp. 843-852.\n R. J. Haynes, “Effects of Soil Acidification on the Chemical Extractability of Fe, Mn, Zn and Cu and the Growth with Micronutrient Uptake of Highbush Blueberry Plants,” Plant and Soil, Vol. 84, No. 2, 1985, pp. 201-212. doi:10.1007/BF02143184", "domain": "chemistry", "round": 3} +{"url": "https://www.redeem-office.com/the-role-of-nad-in-aging-and-longevity/", "date": "2023-09-28T04:07:48Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233510358.68/warc/CC-MAIN-20230928031105-20230928061105-00708.warc.gz", "language_score": 0.9709189534187317, "token_count": 827, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__25260043", "lang": "en", "text": "Nicotinamide adenine dinucleotide, or NAD+, is a coenzyme found in all living cells. In general, NAD+ is used by the body to transfer electrons during the electron transport chain. These electrons are required to produce energy from food. It is necessary for the repair of DNA damage and the replication of DNA and has many other uses too. You can get more NAD+ through your diet by eating specific foods like meat, poultry, fish, legumes, and nuts. There are also many supplement products that contain NAD+ if you aren’t getting enough from the food you eat. If you want to learn more, keep reading to find out about the role of NAD+ in aging and longevity.\nWhat role does NAD+ play in aging and longevity?\nNAD+ is found in two forms in the body, each of which has a unique NAD+ structure. NAD+ is found in its oxidized form, NADH. NADH is converted back to NAD+ in the body by the enzyme NAD+ reductase. The levels of NAD+ decline with age, leading to reduced energy production and increased cell damage. Some experts believe that increasing the levels of NAD+ can improve health and support healthy aging. A popular option for increasing NAD+ levels is to take nicotinamide riboside as a supplement, a form of vitamin B3 that converts into NAD+.\nOne mechanism by which NAD+ may promote longevity is through its role in sirtuin activation. Sirtuins are a family of proteins that regulate gene expression and play a role in aging and metabolism. NAD+ binds to sirtuins, activating them, and this may contribute to an increased lifespan. Additional research is needed to determine how NAD+ supplements can effectively treat or prevent age-related cognitive decline, but the data that has been produced so far is promising. It is likely we will see further developments in the coming years.\nYou can increase NAD+ levels by eating certain foods high in NAD+, like beef liver, yeast, salmon, trout, tuna, mackerel, Brazil nuts, avocados, bananas, and dark chocolate. If you decide to use a supplement, just remember to check with your doctor to find out how it may affect any health conditions you have or interact with the medications you’re currently taking.\nHow else can you stay healthy as you age?\nThere is no question that getting enough sleep is crucial for overall health and well-being, including during the aging process. Unfortunately, many people do not get the recommended amount of sleep each night, which can have a negative impact on overall health and lead to health issues. Some health problems linked to sleep deprivation include high blood pressure, weakened immunity, and an elevated risk of developing mental health conditions like depression or anxiety. Talk to your doctor right away if you’re having trouble sleeping.\nAlthough as we age, our bodies slow down and we are not able to do the things we used to do, this does not mean that we have to sit around the house all the time. It is actually extremely beneficial to stay active, both for our physical and mental health. Regular exercise can improve our mood and mental health, and can even alleviate common symptoms associated with mental health conditions like anxiety and depression. If you’re not currently active, find an activity you like and try to incorporate it into your routine as much as you can.\nNAD+ is a vital molecule that plays a role in many cellular processes, including energy production, DNA repair, and cell death. NAD+ levels decline with age, and this has been linked to age-related diseases and frailty, which is why many people take steps to boost their levels of NAD+, particularly as they begin to get older. You can also take other steps to protect yourself from the premature effects of aging, especially through making healthy lifestyle choices like getting the rest you need and staying as physically active as you can. Follow the tips in this article and you’ll be able to have the best possible experience with aging.", "domain": "chemistry", "round": 3} +{"url": "https://www.conicet.gov.ar/new_scp/detalle.php?keywords=&id=24979&inst=yes&articulos=yes&detalles=yes&art_id=8058831", "date": "2023-09-25T17:49:29Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233509023.57/warc/CC-MAIN-20230925151539-20230925181539-00403.warc.gz", "language_score": 0.8616438508033752, "token_count": 475, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__300335330", "lang": "en", "text": "INSTITUTO DE TECNOLOGIA EN POLIMEROS Y NANOTECNOLOGIA\nUnidad Ejecutora - UE\nA novel, green, low-cost chitosan-starch hydrogel as potential delivery system for plant growth-promoting bacteria\nFRANCOIS, N.J.; PEREYRA, M.A.; MARONICHE, G.A.; CREUS, C.M.; PEREZ, J.J.; BORRAJO, M.P.\nELSEVIER SCI LTD\nAño: 2018 vol. 202 p. 409 - 417\nThe study examines the use of macrobeads for the controlled-release of bacteria. Macrobeads were prepared by an easy dripping-technique using 20/80 wt/wt chitosan-starch blends and sodium tripolyphosphate as cross-linking agent. The resulting polymeric matrix was examined by SEM, XRD, TGA, and solid-RMN. The swelling-equilibrium, thermal behaviour, crystallinity, and size of macrobeads were affected by the autoclave-sterilization. The diameter of the sterilized xerogel was c.a. 1.6 mm. The results suggested that ionotropic-gelation and neutralization were the mechanisms underlying hydrogel formation. Plant growth-promoting bacteria (PGPB) were loaded into macrobeads separately or co-inoculated. Bacteria loaded macrobeads were dried and stored. Bacteria survived at least 12 months in orders of 109 CFU of A. brasilense/g and 108 CFU of P. fluorescens/g. Bacterial release in sterile saline solution tended to a super Case-II transport mechanism. Polymeric-matrix release efficiently both PGPB in natural soils, which uncovers their potential for the formulation of novel and improved biofertilizers.", "domain": "chemistry", "round": 3} +{"url": "https://www.irda.qc.ca/en/about/facilities/sustainable-agriculture-energy-laboratory/", "date": "2023-12-11T16:19:19Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679515260.97/warc/CC-MAIN-20231211143258-20231211173258-00387.warc.gz", "language_score": 0.931191623210907, "token_count": 326, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__244895338", "lang": "en", "text": "The Sustainable Agriculture Energy Laboratory is the first research facility in Canada with an infrastructure that supports the development of green agricultural energy.\nThe Sustainable Agriculture Energy Laboratory houses facilities for research projects that focus on producing energy via the conversion of agricultural waste derived from plants, animals, and dedicated crops.\nThe lab evaluates processes such as pyrolysis and combustion, as well as bioelectrochemical cells, to determine which are best suited for producing sustainable energy on farms.\nDevelop a research program that:\nThe bioelectrochemical cell (BioVeeVmc) developed at IRDA produces electricity from the liquid waste derived from plant and animal sources in just a single step, i.e., without passing through an intermediate methanation phase. It is used, for example, to successfully treat slurry and reduce environmental pollutants, such as odours and pathogenic bacteria.\nPyrolysis converts biomass at a high temperature, in the absence of oxygen, into three by-products: biochar, bio-oil and fuel gas. Besides its role in bioenergy production and waste conversion, certain pyrolysis byproducts have the ability to sequester carbon.\nThanks to an agreement between IRDA and Agriculture and Agri-Food Canada, the Sustainable Agriculture Energy Laboratory has access to two fuel-fired boilers that are used to test four types of biomass—fast-growing willows, switchgrass, amur silver grass, and reed canary grass—and compare them to wood, the control substance. Earlier research at IRDA determined that these crops are the most likely to prosper in Québec.", "domain": "chemistry", "round": 3} +{"url": "https://www.genetex.com/Product/Detail/Livin-antibody/GTX114132", "date": "2022-07-04T00:40:59Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-27/segments/1656104277498.71/warc/CC-MAIN-20220703225409-20220704015409-00632.warc.gz", "language_score": 0.8446035385131836, "token_count": 434, "dump": "CC-MAIN-2022-27", "global_id": "webtext-fineweb__CC-MAIN-2022-27__0__59856775", "lang": "en", "text": "0.1M Tris-Glycine (pH7), 20% Glycerol\nStore as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.\n0.98 mg/ml (Please refer to the vial label for the specific concentration.)\nRecombinant protein encompassing a sequence within the center region of human Livin. The exact sequence is proprietary.\nPurified by antigen-affinity chromatography.\nFor laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.\nbaculoviral IAP repeat containing 7 , KIAP , LIVIN , ML-IAP , MLIAP , RNF50\nNucleus , Cytoplasm\nThe protein encoded by this gene is a member of the family of inhibitor of apoptosis proteins (IAP) and contains a single copy of a baculovirus IAP repeat (BIR) as well as a RING-type zinc finger domain. The BIR domain is essential for inhibitory activity and interacts with caspases, while the RING finger domain sometimes enhances antiapoptotic activity but does not inhibit apoptosis alone. Two transcript variants encoding different isoforms have been found for this gene. The two isoforms have different antiapoptotic properties, with isoform alpha protecting cells from apoptosis induced by staurosporine and isoform b protecting cells from apoptosis induced by etoposide. [provided by RefSeq]", "domain": "chemistry", "round": 3} +{"url": "https://www.24mantra.com/blogs/organic-lifestyle/thumb-rules-to-avoid-pesticides/", "date": "2020-07-13T21:55:26Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-29/segments/1593657146845.98/warc/CC-MAIN-20200713194203-20200713224203-00005.warc.gz", "language_score": 0.9306674599647522, "token_count": 350, "dump": "CC-MAIN-2020-29", "global_id": "webtext-fineweb__CC-MAIN-2020-29__0__208153472", "lang": "en", "text": "- MOST RECENT\nTHUMB RULES TO AVOID PESTICIDES\nWash, wash and wash. Like the way you wash your hands. Just running them under tap water does little to remove oily grime. Agricultural pesticides do not come off in water. Petrochemical companies make pesticides with chemical “stickers” that are insoluble in water.\nSoap, or detergent is effective in removing pesticide residues. Take a squirt of dishwashing detergent, in a large bowl of water. Mix the detergent in thoroughly, and swish the apples around for a minute. Carefully watch the water. You will see evidence that detergent works.\nRinse until the water is clear. The detergent-washed fruit, you will also notice feels different, too. (We are so used to fruit with chemical coatings on it that when we touch truly clean fruit, it’s a new tactile experience).\nMany fruits and vegetables are not merely sprayed, but are waxed as well. So-called “food grade” waxes improve shelf life, appearance, coat over and lock in any previously applied pesticides. This poses a problem, for waxes do not readily dissolve in detergent solution. Simply peel them. Frequently waxed fruits include apples, brinjals and tomatoes. The lack of a high gloss is not proof positive that a fruit is unwaxed: many waxes, like many types of floor polyurethane or spray varnish, are not at all shiny. One way to tell if a fruit or vegetable is waxed is to run your fingernail over it and see if you can scrape anything off.", "domain": "chemistry", "round": 3} +{"url": "https://panel.waset.org/abstracts/100597", "date": "2019-11-13T05:38:51Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-47/segments/1573496665985.40/warc/CC-MAIN-20191113035916-20191113063916-00251.warc.gz", "language_score": 0.9186821579933167, "token_count": 404, "dump": "CC-MAIN-2019-47", "global_id": "webtext-fineweb__CC-MAIN-2019-47__0__110372157", "lang": "en", "text": "Geochemistry and Petrogenesis of Anorogenic Acid Plutonic Rocks of Khanak and Devsar of Southwestern Haryana\nAcid plutonic rocks from the Khanak and Devsar areas of southwestern Haryana were investigated to understand their geochemical and petrogenetic characteristics and tectonic environments. Three dominant rock types (grey, grayish green and pink granites) are the principal geochemical features of Khanak and Devsar areas which reflect the dependencies of their composition on varied geological environment during the anorogenic magmatism. These rocks are enriched in SiO₂, Na₂O+K₂O, Fe/Mg, Rb, Zr, Y, Th, U, REE (Rare Earth Elements) enriched and depleted in MgO, CaO, Sr, P, Ti, Ni, Cr, V and Eu and exhibit a clear affinity to the within-plate granites that were emplaced in an extensional tectonic environment. Chondrite-normalized REE patterns show enriched LREE (Light Rare Earth Elements), moderate to strong negative Eu anomalies and flat heavy REE and grey and grayish green is different from pink granite which is enriched by Rb, Ga, Nb, Th, U, Y and HREE (Heavy Rare Earth Elements) concentrations. The composition of parental magma of both areas corresponds to mafic source contaminated with crustal materials. Petrogenetic modelling suggest that the acid plutonic rocks might have been generated from a basaltic source by partial melting (15-25%) leaving a residue with 35% plagioclase, 25% alkali feldspar, 25% quartz, 7% orthopyroxene, 5% biotite and 3% hornblende. Granites from both areas might be formed from different sources with different degree of melting for grey, grayish green and pink granites.", "domain": "chemistry", "round": 3} +{"url": "http://journals.iupui.edu/index.php/ias/article/view/8003", "date": "2018-06-17T21:50:40Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-26/segments/1529267859817.15/warc/CC-MAIN-20180617213237-20180617233237-00405.warc.gz", "language_score": 0.7133185267448425, "token_count": 482, "dump": "CC-MAIN-2018-26", "global_id": "webtext-fineweb__CC-MAIN-2018-26__0__26254228", "lang": "en", "text": "Ted T. Ashburn, Simone R. Head, and Paul L. Bock. RCHDCHDX Compounds as Stereochemical Probes: Avoiding Deuterium Decoupling.\nThomas W. Avery, Joseph J. Thompson, and Esther R. Surface. Characterization of a Direct Injection Nebulizer.\nDaniel L. Burden and Stanley L. Burden. Technique for Improving Quantification of PPB Level Chloride Determinations in Multicomponent Anion Analysis Using Ion Chromatography with a Pre-Concentration Column.\nR. Dale Delk, Carol L. Walters, Christopher Yamamoto, and Bruce N. Storhoff. Glucose Test Strips as Peroxide Indicators.\nKris Dhawale. Interactions of Iron and Copper with some Sulfur Oxyanions.\nJames E. Fritz, Mary Kay Neeb, and Bruce N. Storhoff. Phosphine-Functionalized Crown Ethers.\nZhengxiang Gu, Macklin B. Arnold, Aron C. Sousa, and Mohammad Beh-Forouz. Synthesis of 7-Acetamido-2-formylquinoline-5,8-dione.\nA.J.C.L. Hogarth. The Nickel(II)-Dimethylglyoxime Complex: A New Use for an Old Compound.\nSuzy Pope, M. Catherine Cosby, and Lynn R. Sousa. A Quest for Flashy Crowns: Progress on a \"Clip-On\" Approach.\nEugene P. Schwartz. Molar Refractions of Metal Ions in Complexes.\nJoseph R. Siefker and Rie-Whun Gihl. Determination of Molar Absorptivities and Formation Constants for Complexes of Copper(II) and Cobalt(II) with 3-Aminopyridine.\nJeffrey J. Stadick, Joseph J. Thompson, and Bruce N. Storhoff. Speciation of Cisplatin and Related Compounds by High Performance Liquid Chromatography with ICP-AES Detection.\nEugene S. Wagner. The Identification of Superoxide Dismutes in Human Serum Using Polyacrylamide Gel Electrophoresis.", "domain": "chemistry", "round": 3} +{"url": "https://www.ars.usda.gov/research/publications/publication/?seqNo115=302844", "date": "2023-09-30T18:36:56Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233510707.90/warc/CC-MAIN-20230930181852-20230930211852-00452.warc.gz", "language_score": 0.9061930775642395, "token_count": 542, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__172484974", "lang": "en", "text": "|THIBODEAUX, DEVRON - Retired ARS Employee|\n|FOULK, JONN - Fx - Fibers Llc|\n|Rodgers Iii, James|\nSubmitted to: Journal of Textile Science & Engineering\nPublication Type: Peer Reviewed Journal\nPublication Acceptance Date: 7/22/2014\nPublication Date: 8/5/2014\nCitation: Liu, Y., Thibodeaux, D., Foulk, J., Rodgers III, J.E. 2014. Preliminary study of determining cotton trash components in lint cottons by near infrared spectroscopy technique. Journal of Textile Science & Engineering. 4(4):1000161.\nInterpretive Summary: Presence of trash in commercial cotton bales at varying amounts degrades the market values, requires additional cleaning process, and impacts the end-use qualities for yarn and fabric products. In order to determine the trash amount, a number of methods have been developed. In general, these methods only produce the amount of total trash, instead of the content for individual or targeted trash components. Near infrared (NIR) spectroscopy, as a rapid and low-cost method that can be used, away from the laboratory, in places such as ginning sites, has been examined for its potential in the prediction of specific and unique cotton trash components (leaves, seed coats, hulls, stems, and sand/soil) in grounded samples. Next, these NIR models were transferred to regular bulky samples with various instrumental leaf grade or trash levels. The accumulated knowledge could be of value as a rapid analytical tool to cotton breeders for cotton variety enhancement and also to cotton ginning engineers for effective trash-removal cleaning devices. The outcome provides cotton fiber/textile engineers, researchers, ginners, and regulators a new way in the determination of cotton trash components.\nTechnical Abstract: The transfer of NIR calibration models for the determination of total trash, leaf trash and non-leaf trash components in cotton fibers was conducted between two sets of samples. These samples to be analyzed are inhomogeneous in a bulky state whereas the samples used as calibrations were much homogeneous in a ground state. The efficacy of the model transfer was evaluated based on instrumental leaf grade readings of diverse samples, because current-in-use trash tests cannot generate the trash amount for individual trash components. Results indicated that the predictions from the direct model transfer were unreliable, but they might be acceptable after the correction or conversion of original predictions with standard samples.", "domain": "chemistry", "round": 3} +{"url": "https://hetapi.giamcan-ankieng.com/what_is_manual_transmission_oil.aspx", "date": "2018-11-14T13:37:57Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-47/segments/1542039742020.26/warc/CC-MAIN-20181114125234-20181114151234-00225.warc.gz", "language_score": 0.9263098835945129, "token_count": 290, "dump": "CC-MAIN-2018-47", "global_id": "webtext-fineweb__CC-MAIN-2018-47__0__89951102", "lang": "en", "text": "How can the answer be improved?. Manual transmission fluid can vary, however, using either plain motor oil, a transmission oil known as heavyweight hypoid gear oil, or automatic transmission fluid. The type of transmission fluid to use in vehicles with standard transmissions can usually be found in the maintenance section of the owner’s manual.. Transmission oil is a mixture of base oil and additives with very good anti-wear and anti-scoring properties and good stability to thermal oxidation. Manual transmissions use a variety of oils: regular motor oil, heavyweight hypoid gear oil or even automatic transmission fluid in some cases.. It is important to use the correct fluid oil in you manual transmission, the vehicle manufacturers have done extensive testing to specify the correct fluid. The oil is designed to reduce friction and provide necessary cooling. Information is provide for most vehicles.. Some manual trans. take 10w30 motor oil some take dextron auto trans fluid some take hypoid oil. It can be different in the same year, what is in there is correct regardless what the store/manual says.. Manual transmission fluid is an oil, thicker than engine oil and will be given a number in your vehicle service manual prefixed by two or three letters. Do not mistake it as oil for the engine as it will seriously reduce the vehicles life.. MAKE MODEL / YEAR Symbol Fluid Specification Valvoline Product Chrysler Trucks all vehicles except as noted NV 1500 manual Transmission ….", "domain": "chemistry", "round": 3} +{"url": "https://www.novusbio.com/antibody-news/antibodies/fanconi-antibodies-and-cancer-research", "date": "2024-04-14T01:03:15Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712296816863.40/warc/CC-MAIN-20240414002233-20240414032233-00896.warc.gz", "language_score": 0.9507601857185364, "token_count": 429, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__2625297", "lang": "en", "text": "We at Novus Biologicals have an extensive antibody databasedevoted to the 13 Fanconi anaemia complementation (FANC) genes, which are involved in the recognition and repair of damaged DNA.\nThe core complex of 8 proteins (FANCA, B, C, E, F, G, L and M) are of particular interest to cancer groups, as defects in these proteins are known to cause Fanconi's anemia, which carries a higher risk of cancer developing. The complex is also associated with the breast cancer susceptibility gene BRCA2. Recently, we extended our antibody catalog with the addition of several SDIX GAT (Genome Antibody Technology) reagents.\nUnder normal circumstances, the core complex is activated in response to DNA damage, the trigger being the cessation of replication. The proteins interact with BRCA2 by addition of ubiquitin (ubiquitinization) which then facilitates repair. Recent studies have been able to look at this process in depth.\nImmunocytochemistry: Fanconi Anemia Antibody Pack\nIt is thought the 8 proteins in the core complex migrate from the cytoplasm to the nucleus following nuclear localization signalling of FANCA and FANCE. Assembly of the complex is activated by replication stress, in particular DNA damage caused by cross-linking agents or oxidative stress caused by ROS (reactive oxygen species). The assembled complex then triggers FANCL, an E3 ubiquitin ligase protein which monoubiquitinates FANCD2. This then interacts with the BRCA1/BRCA2 complex.\nIt is now known that there are several similar complexes involved in DNA damage recognition and repair activation, which interact with the FA genes. Recently, researchers identified two novel proteins – christened MHF1 and MHF2 – associated with the core protein FANCM. Antibody supplierslike us at Novus Biologicals are constantly revising our catalogs as new discoveries are made.\nNovus Biologicals offers many Fanconi anemia reagents for your research needs including:", "domain": "chemistry", "round": 3} +{"url": "https://scholarworks.utrgv.edu/som_pub/492/", "date": "2023-03-24T19:31:31Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-14/segments/1679296945288.47/warc/CC-MAIN-20230324180032-20230324210032-00265.warc.gz", "language_score": 0.7772433161735535, "token_count": 468, "dump": "CC-MAIN-2023-14", "global_id": "webtext-fineweb__CC-MAIN-2023-14__0__220151490", "lang": "en", "text": "School of Medicine Publications and Presentations\nLimited Impact of the Protein Corona on the Cellular Uptake of PEGylated Zein Micelles by Melanoma Cancer Cells\nThe formation of a protein layer \"corona\" on the nanoparticle surface upon entry into a biological environment was shown to strongly influence the interactions with cells, especially affecting the uptake of nanomedicines. In this work, we present the impact of the protein corona on the uptake of PEGylated zein micelles by cancer cells, macrophages, and dendritic cells. Zein was successfully conjugated with poly(ethylene glycol) (PEG) of varying chain lengths (5K and 10K) and assembled into micelles. Our results demonstrate that PEGylation conferred stealth effects to the zein micelles. The presence of human plasma did not impact the uptake levels of the micelles by melanoma cancer cells, regardless of the PEG chain length used. In contrast, it decreased the uptake by macrophages and dendritic cells. These results therefore make PEGylated zein micelles promising as potential drug delivery systems for cancer therapy.\nMeewan, J., Somani, S., Laskar, P., Irving, C., Mullin, M., Woods, S., Roberts, C. W., Alzahrani, A. R., Ferro, V. A., McGill, S., Weidt, S., Burchmore, R., & Dufès, C. (2022). Limited Impact of the Protein Corona on the Cellular Uptake of PEGylated Zein Micelles by Melanoma Cancer Cells. Pharmaceutics, 14(2), 439. https://doi.org/10.3390/pharmaceutics14020439\nCreative Commons License\nThis work is licensed under a Creative Commons Attribution 4.0 International License.\nImmunology and Microbiology\n© 2022 by the authors.", "domain": "chemistry", "round": 3} +{"url": "https://www.technologynetworks.com/genomics/posters/highthroughput-analysis-of-dna-samples-using-the-d1k-screentape-assay-and-the-agilent-2200-tapestation-system-229869", "date": "2017-01-23T17:10:48Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-04/segments/1484560282935.68/warc/CC-MAIN-20170116095122-00135-ip-10-171-10-70.ec2.internal.warc.gz", "language_score": 0.8525570631027222, "token_count": 363, "dump": "CC-MAIN-2017-04", "global_id": "webtext-fineweb__CC-MAIN-2017-04__0__26711967", "lang": "en", "text": "High-Throughput Analysis of DNA Samples using the D1K ScreenTape Assay and the Agilent 2200 TapeStation System\nPoster Nov 05, 2012\nArunkumar Padmanaban, Ruediger Salowsky, Adam Inche\nRecent advances in genomics demands to look at a wealth of genetic information in a short period of time. DNA analysis using slab gel electrophoresis and capillary electrophoresis are widely being used as a QC step in next generation sequencing and microarray studies. However, often these techniques lack the speed and involve more manual steps to perform the assay. The Agilent 2200 TapeStation system meets this demand by providing a simple to use automated electrophoresis platform with variable throughput capabilities from one or two samples up to a 96-well plate. The Agilent 2200 TapeStation system along with the D1K ScreenTape assay can analyze a full 96-well plate in less than 100 minutes with minimal manual intervention.\nHigh Throughput Rheological Characterization of Small Volume Biopharmaceutical FormulationsPoster\nImportance of assessing viscosity fingerprints of small molecules.READ MORE\nApplications of chemically modified synthetic guide RNA for CRISPR-Cas9 genome editingPoster\nOur results indicate that MS modifications are required for experiments with co-electroporation of Cas9 mRNA and synthetic gRNA, yet have no impact on editing efficiency when delivered with lipid-based transfection reagents.READ MORE\nHighly Accurate HCV Genotyping by Targeted Next Generation SequencingPoster\nThe recent fast advancement of next generation sequencing (NGS) technologies allowing for unprecedented speed and accuracy in analyzing viral genomes are opening new ways to further improve diagnostic genotyping of HCV.", "domain": "chemistry", "round": 3} +{"url": "https://star-dresden.de/ooxygen/?lang=en", "date": "2019-09-23T18:38:27Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-39/segments/1568514577478.95/warc/CC-MAIN-20190923172009-20190923194009-00111.warc.gz", "language_score": 0.8795338273048401, "token_count": 262, "dump": "CC-MAIN-2019-39", "global_id": "webtext-fineweb__CC-MAIN-2019-39__0__158245645", "lang": "en", "text": "The measurement of oxygen concentration is becoming more and more important, in an age where most modern devices are equipped with an ever increasing range of sensors. On the one hand, this type of sensor serves a scientific purpose, such as a detailed observation of the Earth’s atmosphere. On the other hand, machines equipped with sensor technology play a valuable role in daily life through the analysis of technical processes which require the measurement of oxygen concentration, e.g. combustion processes in automobiles and power plants.\nOur aim is to test a novel oxygen sensor which is based on the principle of biluminescence. The ambient oxygen concentration is to be continuously measured during the balloon flight, and a concentration profile of the flight generated. In contrast to traditional optical oxygen sensors, the biluminescence-based sensor does not suffer from photodegradation. A distinguishing feature of the sensor is that it is composed solely of organic electronics, which allows a cost-effective and material-saving production.\n|Jakob Lindenthal||Sensor development, project leader|\n|Rico Nerger||Structures, systems engineering|\n|Elias Ortlieb||IT, outreach|\n|Benedikt Boos||Thermal, structures|\n|Nicklas Marth||Electronics, thermal design|", "domain": "chemistry", "round": 3} +{"url": "https://www.dlyte.com/company/about-us/", "date": "2023-11-30T01:14:46Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100164.15/warc/CC-MAIN-20231130000127-20231130030127-00738.warc.gz", "language_score": 0.9277443289756775, "token_count": 330, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__61184645", "lang": "en", "text": "In 2016, GPAINNOVA and its brand DLyte released DryLyte, the first dry electropolishing process for metal pieces. After registering this unique new technology worldwide, the company maintained steady growth until becoming the 4th fastest growing European industrial goods company by 2022, according to Financial Times.\nDLyte automates, simplifies, and standardizes the surface finishing process of metal parts. It provides a high-performance solution for the most demanding metals and alloys in industrial companies and offers a wide range of advantages over traditional polishing systems, which improves the performance of every single treated piece.\nMetal parts used for high-precision applications must meet tight geometric tolerances and have very low roughness at a microscopic level to ensure minimal friction, exact mating, and high resistance to wear and failure. These include increased corrosion, fatigue, and erosion resistance, a longer life span, biocompatibility, greater adherence of subsequent coatings, and better appearance and gloss.\nApplications for the patented DryLyte Technology can be used for lapping, rounding, deburring, surface smoothing and high gloss polishing of aesthetic parts. It is suitable for several sectors, such as dental, medical, or industrial applications, including additive manufacturing (AM).\nDLyte is part of GPAINNOVA, a technological platform established in Barcelona in April 2013 and specializing in surface finishing for metal parts. This business group focuses on the design, manufacturing and marketing of machines based on the DryLyte Technology. GPAINNOVA counts on DLyte Chemicals, the company that manufactures and markets its consumable materials.", "domain": "chemistry", "round": 3} +{"url": "http://www.lindberghfoundation.org/docs/index.php/hernandez-mark?fontstyle=f-smaller", "date": "2015-01-29T14:21:57Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2015-06/segments/1422115855094.38/warc/CC-MAIN-20150124161055-00155-ip-10-180-212-252.ec2.internal.warc.gz", "language_score": 0.9234989881515503, "token_count": 290, "dump": "CC-MAIN-2015-06", "global_id": "webtext-fineweb__CC-MAIN-2015-06__0__149676390", "lang": "en", "text": "Dr. Mark T. Hernandez, University of Colorado at Boulder, Boulder, Colorado\n\"Balancing the Preservation of our Natural Environment with Mandatory Aircraft Deicing Practices\"\nCategory: Aviation/Aerospace: 1998\nWhile the use of aircraft deicing fluids ensures safe flying operations in cold weather, this practice also generates millions of gallons of contaminated runoff and concentrated wastes each year. Storm water runoff, contaminated with aircraft deicing fluids (ADF), can deplete oxygen levels and threaten oxygen-dependent aquatic life in surface waters. Unless it is collected in the storm water system, deicing waste is discharged directly into the environment. Recent surveys have shown that less than 50% of ADF applied to aircraft is actually recovered and treated. Previous studies have shown that pure glycols are biodegradable and non-toxic; however, common additives to aircraft deicing fluids have been implicated in adding biological toxicity to deicing wastes. Negative impacts on waste water treatment facilities caused by raw ADF waste have cause utilities to begin enforcing strict discharge limits and fee assessments from airports. This is forcing airports and airbases to investigate alternative methods to manage ADF wastes. Results from this work will provide a realistic assessment for the potential on-site treatment of raw ADF wastes through anaerobic (bacterial) digestion and independent stabilization ponds and their visibility as a pre-treatment option for raw land application or discharge to a waste water treatment facility.", "domain": "chemistry", "round": 3} +{"url": "https://link.springer.com/article/10.1007/s10812-012-9648-5?error=cookies_not_supported&code=bcff8267-13a9-4974-acae-ce8125eecbf3", "date": "2023-12-04T00:32:48Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100518.73/warc/CC-MAIN-20231203225036-20231204015036-00030.warc.gz", "language_score": 0.6888214945793152, "token_count": 1990, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__302136739", "lang": "en", "text": "Two simple, sensitive, selective, accurate, and cost-effective spectrophotometric methods are described for the assay of oxcarbazepine (OXC) in bulk drug and in tablets. The methods are based on an oxidative coupling reaction involving OXC, 3-methylbenzothiazolin-2-one hydrazone (MBTH), and cerium(IV) sulfate at pH 4.28 ± 0.07 (method A) or sodium periodate at pH > 4.0 (method B) to form an orange colored product with an absorption maximum at 450 nm. Under optimized experimental conditions, the calibration graphs are linear over the ranges of 4–80 and 2–32 μg/ml for methods A and B, respectively, with correlation coefficient (r) values of 0.9984 and 0.9976. The apparent molar absorptivity values are 3.13⋅103 and 9.13⋅103 l/mol⋅cm for methods A and B, respectively. The other optical characteristics such as Sandell’s sensitivity, limits of detection (LOD) and quantification (LOQ) values are also reported. The accuracy and precision of the methods were evaluated based on intra-day and inter-day variations. The proposed methods were successfully applied to the determination of OXC in tablets: the results were comparable with the published data obtained using the reference method. The reaction stoichiometry of OXC with MBTH (1:1 in method A and 1:2 in method B) was also evaluated using the limiting logarithmic method, and a possible reaction pathway is presented for the both methods.\nThis is a preview of subscription content, access via your institution.\nBuy single article\nInstant access to the full article PDF.\nPrice excludes VAT (USA)\nTax calculation will be finalised during checkout.\nM. Mazza, G. Della Marca, M. Di Nicola, G. Martinotti, G. Pozzi, L. Janiri, P. Bria, S. Mazza, Epilepsy Behav., 10, 397–401 (2007).\nS. N. Ghaemi, D. A. Berv, J. Klugman, K. J. Rosenquist, D. J. Hsu, J. Clin. Psychiatry, 64, 943–945 (2003).\nJ. M. Juenke, P. I. Brown, F. M. Urry, G. A. McMillin, J. Chromatogr. Sci., 44, 45–48 (2006).\nM. L. Qi, P. Wang, L. J. Wang, R.N. Fu, J. Pharm. Biomed. Anal., 31, 57–62 (2003).\nK. S. Rao, N. Belorkar, M. E.B. Rao, Pharm. Anal. J. Young Pharm., 1, 270–277 (2009).\nE. Greiner-Sosanko, S. Giannoutsos, D. R. Lower, M. A. Virji, M. D. Krasowski, J. Chromatogr. Sci., 45, 616–622 (2007).\nT. S. Reddy, P. S. Devi, J. Planar Chromatogr. MTLC, 20, 451–456 (2007).\nM. Ivanova, E. Marziali, M. A. Raggi, E. Kenndler, J. Sep. Sci., 25, 863–871 (2002).\nE. Marziali, M. A. Raggi, N. Komarova, E. Kenndler, Electrophoresis, 23, 3020–3026 (2002).\nB. Paw, K. Wos, J. Preclin. Clin. Res., 2157–2159 (2008).\nM. Encarnacion Burgoa Calvo, Olga Dominguez Renedo, M. Julia Arcos Martinez, J. Pharm. Biomed. Anal., 43, 1156–1160 (2007).\nO. Dominguez Renedo, M. E. Burgoa Calvo, M. A. Alonso-Lomillo, M. J. Arcos-Martinez, Sensor Lett., 8, 268–272 (2010).\nC. S. Ramaa, P. P. Chothe, A. A. Naik, V. J. Kadam, Indian J. Pharm. Sci., 68, 265–266 (2006).\nM. A. Sathish, G. Nagendrappa, Int. J. Pharm. Pharm. Sci., 2, 93–98 (2010).\nM. Gandhimathi, T. K. 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Vogel, A Quantitative Inorganic Analysis Including Elementary Instrumental Analysis, 3rd ed., Long-man Group Ltd, London, 319 (1961).\nInternational Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use, ICH Harmonised Tripartite Guideline, Validation of Analytical Procedures: Text and Methodol-ogy Q2(R 1),Complementary Guideline on Methodology dated 06 November 1996, incorporated in November 2005, London.\nE. Sawicki, T. W. Stanley, T. R. Hauser, W. Elbert, J. L. Noe, Anal. Chem., 33, 722–725 (1961).\nM. Pays, R. Bourdon, M. Beljean, Anal. Chim. Acta, 47, 101–111 (1969).\nY. Ni, C. Liu, S. Kobet, Anal. Chim. Acta, 419, 185–196 (2000).\nH. D. Revanasiddappa, B. Manju, P. G. Ramappa, Anal. Sci., 15, 661–664 (1999).\nA. A. Al-Mazed, F. Belal, N. Y. Khalil, K. E. Ibrahim, J. AOAC Int., 87, 352–359 (2004).\nJ. Rose, Advanced Physical Chemical Experiments, Pitman, London, 67 (1965).\nH. Zavis, D. Ludvik, K. Milan, S. Ladislaw, V. Frantisck, Handbook of Organic Reagents in Inorganic Analysis. Translated by Stanislav, K, Dr. Chalmers (The Series and Translation Editor: University of Aberdem, Ellis Horwood Limited, Chichester, A Division of John Wiley & Sons IC, New York, London, Sydney, Toronto (1976).\nJ. Inczedy, T. Lengyel, A. M. Ure, IUPAC Compendium of Analytical Nomenclature: Definitive Rules, Blackwell Science Inc., Boston (1998).\nPublished in Zhurnal Prikladnoi Spektroskopii, Vol. 79, No. 4, pp. 631–640, July–August, 2012.\nAbout this article\nCite this article\nRajendraprasad, N., Basavaiah, K. & Vinay, K.B. Application of 3-methylbenzothiazolin-2-one hydrazone for the quantitative spectrophotometric determination of oxcarbazepine in pharmaceuticals with cerium(IV) and periodate. J Appl Spectrosc 79, 616–625 (2012). https://doi.org/10.1007/s10812-012-9648-5", "domain": "chemistry", "round": 3} +{"url": "https://saemobilus.sae.org/content/2001-01-3632", "date": "2020-03-29T13:15:08Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-16/segments/1585370494331.42/warc/CC-MAIN-20200329105248-20200329135248-00348.warc.gz", "language_score": 0.7770549058914185, "token_count": 2245, "dump": "CC-MAIN-2020-16", "global_id": "webtext-fineweb__CC-MAIN-2020-16__0__232696937", "lang": "en", "text": "This content is not included in your SAE MOBILUS subscription, or you are not logged in.\nOxygenates screening for AdvancedPetroleum-Based Diesel Fuels: Part 2. The Effect of Oxygenate Blending Compounds on Exhaust Emissions\nISSN: 0148-7191, e-ISSN: 2688-3627\nPublished September 24, 2001 by SAE International in United States\nAnnotation ability available\nEvent: Spring Fuels & Lubricants Meeting & Exhibition SAE International Fall Fuels & Lubricants Meeting & Exhibition\nAdding oxygenates to diesel fuel has shown the potential for reducing particulate (PM) emissions in the exhaust. The objective of this study was to select the most promising oxygenate compounds as blending components in diesel fuel for advanced engine testing. A fuel matrix was designed to consider the effect of molecular structure and boiling point on the ability of oxygenates to reduce engine-out exhaust emissions from a modern diesel engine. Nine test fuels including a low-sulfur (∼1 ppm), low-aromatic hydrocracked base fuel and 8 oxygenate-base fuel blends were utilized. All oxygenated fuels were formulated to contain 7% wt. of oxygen. A DaimlerChrysler OM611 CIDI engine for light-duty vehicles was controlled with a SwRI Rapid Prototyping Electronic Control System. The base fuel was evaluated in four speed-load modes and oxygenated blends only in one mode. Each operating mode and fuel combination was run in triplicate. The Bosch smoke number, total PM, total volatile fraction (TVF), NOx, CO, THC, CO2, and O2 were measured. Dry PM, which is assumed to form during the combustion process, was calculated by subtracting the TVF from the total PM. PM emissions reductions were proportional to the oxygen content of the fuel, averaging 26.1 percent below that of base fuel. Spread in the dry PM emissions indicated that fuel properties other than oxygen content play a role in the soot formation mechanism. In some cases, NOx emissions can increase significantly. Based on Total PM emissions and other considerations, Tripropylene Glycol Mono-Methyl Ether and Di Butyl Maleate were identified as the most promising candidate oxygenate compounds for future engine testing.\n- Manuel A. González D. - PDVSA Intevep\n- William Piel - Consultant\n- Tom Asmus - DaimlerChrysler\n- Wendy Clark - National Renewable Energy Laboratory\n- John Garbak - U. S. Department of Energy\n- Eleanor Liney - Equilon Enterprises\n- Mani Natarajan - Marathon Ashland Petroleum Company\n- David W. Naegeli - Southwest Research Institute\n- Doug Yost - Southwest Research Institute\n- Edwin A. Frame - Southwest Research Institute\n- James P. Wallace - Wallace Associates\nCitationGonzález D., M., Piel, W., Asmus, T., Clark, W. et al., \"Oxygenates screening for AdvancedPetroleum-Based Diesel Fuels: Part 2. The Effect of Oxygenate Blending Compounds on Exhaust Emissions,\" SAE Technical Paper 2001-01-3632, 2001, https://doi.org/10.4271/2001-01-3632.\nSAE 2001 Transactions Journal of Fuels and Lubricants\nNumber: V110-4; Published: 2002-09-15\nNumber: V110-4; Published: 2002-09-15\n- McCormick, R.L., Ross, J.D., and Graboski, M.S., “Effect of Several Oxygenates on Regulated Emissions from Heavy-Duty Diesel Engines,” Environ. Sci. Technol. 1997, 31, 1144-1150.\n- Stoner, M. and Litzinger, T., “Effects of Structure and Boiling Point of Oxygenates Blending Compounds in Reducing Diesel Emissions,” SAE Paper 1999-01-1475.\n- Litzinger, T. and Stoner, M., “Effects of Oxygenated Blending Compounds on Emissions from a Turbo-charged Direct Injection Diesel Engine.” International Journal of Engine Research, Vol. 1, pp. 57-70, 2000.\n- Miyamoto, N., Ogawa, H., Arima, T., and Miyakawa, K., “Improvement of Diesel Combustion and Emissions with Addition of Various Oxygenated Agents to Diesel Fuels,” SAE Paper 962115.\n- Miyamoto, N., Ogawa, H., Nurun, Obata, and Arima, T., “Smokeless, Low NOx, High Thermal Efficiency, and low Noise Diesel Combustion with Oxygenated Agents as Main Fuel,” SAE Paper 980506.\n- Tsurntani, K., Takei, Y., Fujimoto, Y., Matsudaira, J., Kumamoto, M. “The Effects of Fuel Properties and Oxygenates on Diesel Exhaust Emissions,” SAE Paper 952349.\n- Uchida, M., and Akasaka, Y., “A Comparison of Emissions from Clean Diesel Fuels,” SAE 1999-01-1121.\n- Akasaka, Y., Sasaki, T., Kato, S., and Onishi, S., “Evaluation of Oxygenated Fuel by Direct Injection Diesel and Direct Fuel Injection Impingement Diffusion Combustion Diesel Engines,” SAE Paper 901566.\n- Akasaka, Y., and Sakurai, Y., “Effects of Oxygenated Fuel and Cetane Improver on Exhaust Emissions from Heavy-Duty DI Diesel Engines,” SAE Paper 942023.\n- Akasaka, Y., Suzuki, T., and Sakurai, Y., “Exhaust Emissions of a DI Diesel Engine Fueled with Blends of Biodiesel and Low Sulfur Diesel Fuel,” SAE Paper 972998.\n- Liotta, F.J. and Montavio, D.M., “The Effect of Oxygenated Fuels on Emissions from a Modern Heavy-Duty Diesel Engine,” SAE Paper 932784.\n- Tamanouchi, M., Akimoto, T., Aihara, S., and Morihisa, H., “Effects of DGM and Oxidation Catalyst on Diesel Exhaust Emissions,” SAE Paper 1999-01-1137.\n- Beatrice, C., Bertoli, C., Del Giacomo, N., and Migliaccio, M., “Potentiality of Oxygenated Synthetic Fuel and Reformulated Fuel on Emissions from a Modern DI Diesel Engine,” SAE Paper 1999-01-3595.\n- Ullman, T.L., Spreen, K.B. and Mason R.L., “Effects of Cetane Number, Cetane Improver, Aromatics, and Oxygenates on 1994 Heavy-Duty Diesel Engine Emissions,” SAE Paper 941020.\n- Spreen, K.B., Ullman, T.L., Mason, R.L., “Effects of Cetane Number, Aromatics, and Oxygenates on Emissions from a 1994 Heavy-Duty Diesel Engine with Exhaust Catalyst,” SAE Paper 950250.\n- Nkakita, K., Takasu, S., Ban, H., Ogawa, T., Naruse, H., Tsukasaki, Y., and Yeh, L.I., “Effect of Hydrocarbon Molecular Structure on Diesel Exhaust Emissions Part 1: Comparison of Combustion and Exhaust Emission Characteristics Among Representative Diesel Fuels,” SAE Paper 982494.\n- Nkakita, K., Takasu, S., Ban, H., Ogawa, T., Naruse, H., Tsukasaki, Y., and Yeh, L.I., “Effect of Hydrocarbon Molecular Structure on Diesel Exhaust Emissions Part 2: Effect of Branched and Ring Structures on Paraffins on Benzene and Soot Formation,” SAE Paper 982494.\n- Takahashi, F. and Glassman, I., “Sooting Correlations for Premixed Flames,” Combustion Science and Technology, 37, pp. 1-19, 1984.\n- Sirman, M.B., Owens, E.C., and Whitney, K.A., “Emissions Comparison of Alternative Fuels in an Advanced Automotive Diesel Engine,” SAE Paper 2000-01-2048.\n- Vertin, K.D., Ohi, J.M., Naegeli, D.W., Childress, K.H., Hagen, G.P., McCarthy, C.I., Cheng, A.S., Dibble, R.W., “Methylal and Methylal-Diesel Blended Fuels for Use in Compression-Ignition Engines,” SAE Paper 1999-01-1508.\n- Ball, J.C., Lapin, C., Buckingham, J., Frame, E., Yost, D., Gonzalez, M., Liney, E., Natarajan, M., and Wallace, J.P.III, “Dimethoxy Methane in Diesel Fuel: Part 1. The effect of engine operating mode and fuels on emissions of toxic air pollutants and gas and solid phase PAH” SAE Paper 01FL-513 (2001).\n- Newkirk, M. S., “Application of Methods for Determining Total Organic Contribution to Diesel Particulates,” Transactions of ASME, Vol 114, July 1992.\n- Oxygenates for Advanced Petroleum-Based Fuels: Part 1. Screening and Selection Methodology for the Oxygenates. Natarajan M., Naegeli D. W., Frame E. A., Asmus T., Clark W., Garbak J., González D. Manuel A., Liney E., Piel W. and Wallace James P III.. SAE Paper 01FL-576 (2001).\n- Hodgman, C.D., Weast, R.C., and Selby, S.M., Handbook of Chemistry and Physics, 39 th Ed. (1957-58) pp. 1778-1786.", "domain": "chemistry", "round": 3} +{"url": "https://pubag.nal.usda.gov/catalog/6137259", "date": "2019-10-17T10:35:43Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-43/segments/1570986673538.21/warc/CC-MAIN-20191017095726-20191017123226-00093.warc.gz", "language_score": 0.8633961081504822, "token_count": 373, "dump": "CC-MAIN-2019-43", "global_id": "webtext-fineweb__CC-MAIN-2019-43__0__39184148", "lang": "en", "text": "Jump to Main Content\nTransient activation of AMP-activated protein kinase at G1/S phase transition is required for control of S phase in NIH3T3 cells\n- Park, In-Ja, Tran, Quynh Hoa, Amin, Ain Syafiza Mohd, Chu, Thanh Lan, Yang, Goowon, Choe, Wonchae, Kang, Insug, Kim, Sung Soo, Ha, Joohun\n- Biochemical and biophysical research communications 2018 v.504 no.2 pp. 367-373\n- AMP-activated protein kinase, calcium, energy, homeostasis, interphase, monitoring, phase transition\n- AMP-activated protein kinase (AMPK) functions as a cellular energy sensor by monitoring the cellular AMP:ATP ratio and plays a central role in cellular and whole-body energy homeostasis. Recent studies have suggested that AMPK also contribute to cell cycle regulation, but its role in this field remains almost elusive. In the present study, we report that AMPKα1 was transiently activated during G1/S transition phase in NIH3T3 cells in the absence of any metabolic stress. Inhibition of AMPK activity at G1/S transition phase completely blocked cells from entering S phase; in contrast, persistent activation of AMPK at G1/S transition phase allowed cells to normally enter S phase, but these cells failed to proceed to G2/M phase, stacking at S phase. We further demonstrated that activation of AMPK at G1/S transition phase depends on Ca2+ transients and CaMKKβ activity, but not on energy status. Collectively, these data indicate that temporal regulation of AMPK is required for proper control of S phase in NIH3T3 cells.", "domain": "chemistry", "round": 3} +{"url": "http://www.innovations-report.com/html/reports/engineering/pipe-fittings-crp-bring-benefits-dupont-teflon-pfa-197791.html", "date": "2017-02-23T12:05:59Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-09/segments/1487501171166.18/warc/CC-MAIN-20170219104611-00558-ip-10-171-10-108.ec2.internal.warc.gz", "language_score": 0.9200707674026489, "token_count": 1482, "dump": "CC-MAIN-2017-09", "global_id": "webtext-fineweb__CC-MAIN-2017-09__0__119598849", "lang": "en", "text": "CRP has recently started commercial production of large diameter pipe fittings (up to 14 inches) for the chemical processing industry that are lined in DuPont™ Teflon® PFA fluoropolymer resin. It uses Teflon® PFA because it provides the highest resistance to permeation of all of the fluoropolymers and is the material of choice for the most aggressive conditions.\nResponding to market requirements, CRP has worked to increase the size range of pipe-fittings lined with Teflon® PFA from 6 inch (DN150) to 14 inch (DN350) – a four-fold increase in product scale.\n“It is no small achievement to create the ability to transfer mould 25 kilogrammes of PFA, to get it to where it needs to be and then cool it, all with the lowest melt flow rate PFA,” explains Michael Bruemmer, sales and marketing director at CRP. “We have found Teflon® PFA 350T-J to be the most reliable consistent material for this process, having great thermal stability, resistance to stress cracking and a generally very forgiving character in use. Moreover, with a translucent polymer the results look great and speak for themselves.”\nPFA also facilitates installation, not only with regard to its one-piece design, but also because PFA moulded flanges do not exhibit the classical memory effect, enabling fittings be taken out of line without worrying about flare faces lifting. Moreover, the superior creep performance of Teflon® PFA means that flanges require much less re-tightening to achieve a seal in process. The fittings can withstand the full pressure requirement of ASME B16.5 group 1.1 materials of 14 bar at a maximum temperature of 200°C.\nProcess pipework used in multi-purpose pharmaceutical plants is often required to convey different materials. The exceptionally smooth surface and low wettability of Teflon® PFA assists both cleaning and changeover. Similarly, during high-purity sulphuric and hydrofluoric acid production, the cleanliness of PFA is a key attribute, as Michael Bruemmer confirms: “One of our customers working in the semi-conductor industry measures contamination in terms of parts per trillion – the equivalent of one drop of water in 20 Olympic-sized swimming pools. The ultra high-purity of Teflon® PFA can provide confidence in such cases that no contamination of the process media can occur.”\nFor its customers conveying non-conducting materials such as solvents, CRP has already proven 14 inch sizes using Teflon® PFA C-980, the conductive “anti-static” grade of PFA from DuPont. The material’s excellent conductivity allows the discharge of electrostatic charges generated within pipelines.\n“Of all of the superior attributes provided by Teflon® PFA in these applications, it is perhaps permeation performance that has proven to be the most important,” concludes Michael Bruemmer. “Liner collapse through permeation and inadequate venting can lead to significant plant failures and extended shutdowns – something that none of our customers want. One of our key customers, working with particularly permeant substances, specifies vent bosses with PTFE plugs on all of their PTFE-lined pipe spools in order to manage the permeant liquid through the piping system. This same customer doesn’t bother with the venting system on the adjacent PFA fittings because of their experience of reduced permeation through these fittings. Proof if it was needed.”Established in 1983, CRP manufacture and supply PTFE and PFA lined piping, PFA lined valves, PTFE bellows, sight glasses and sampling systems for the chemical, pharmaceutical and associated processing industries. The United Kingdom's largest manufacturer of PTFE lined pipe, all of its lining processes are conducted and controlled at their facility in Northern England. CRP is supported with qualified manufacturing distributors around the world.\nDuPont (NYSE: DD) has been bringing world-class science and engineering to the global marketplace in the form of innovative products, materials, and services since 1802. The company believes that by collaborating with customers, governments, NGOs, and thought leaders we can help find solutions to such global challenges as providing enough healthy food for people everywhere, decreasing dependence on fossil fuels, and protecting life and the environment. For additional information about DuPont and its commitment to inclusive innovation, please visit www.dupont.com.The DuPont Oval Logo, DuPont™, The miracles of science™ and Teflon® are registered trademarks or trademarks of DuPont or its affiliates.\nFraunhofer IWS Dresden collaborates with a strong research partner in Singapore\n15.02.2017 | Fraunhofer-Institut für Werkstoff- und Strahltechnik IWS\nRussian researchers developed high-pressure natural gas operating turbine-generator\n06.02.2017 | Peter the Great Saint-Petersburg Polytechnic University\nIn the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport\nCells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...\nThe Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.\nThe 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...\nNature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...\nNanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole (\"antidot\") three magnetic states can be configured. The results have been published in the journal \"Scientific Reports\".\nPhysicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...\n13.02.2017 | Event News\n10.02.2017 | Event News\n09.02.2017 | Event News\n23.02.2017 | Health and Medicine\n23.02.2017 | Life Sciences\n23.02.2017 | Life Sciences", "domain": "chemistry", "round": 3} +{"url": "http://m-csf.com/items-all/2192-mbs-polyclonals/2303-anti-m-csf-receptor-antibody", "date": "2024-03-04T05:40:18Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707947476413.82/warc/CC-MAIN-20240304033910-20240304063910-00547.warc.gz", "language_score": 0.8149607181549072, "token_count": 805, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__56548542", "lang": "en", "text": "French translation anticorps\nAntigen M-CSF Receptor\nApplications Western Blot (WB)\nGene name M-CSF Receptor ; M-CSF\nClone Not applicable to Polyclonal Antibodies\nLong name Phospho-M-CSF Receptor (Tyr809) Antibody\nSynonim names CSF1R C-FMS CD115 CSF-1-R CSFR EC 22.214.171.124 FIM2 FMS\nSpecificity This is an antibody designed to detect M-CSF Receptor ; M-CSF\nReacts with Human (Homo sapiens), Mouse (Mus musculus), Rat (Rattus norvegicus)\nConcentration Enquire us for detailed information on the concentration of this antibody\nGene synonims CSF1R; CSF1R; FMS; CSFR; FIM2; HDLS; C-FMS; CD115; CSF-1R; M-CSF-R; FMS; CSF-1-R; CSF-1R; M-CSF-R\nProperties If you buy Antibodies supplied by MBS Polyclonals they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.\nPurification method The most common purification methods used in the antibody production are Affinity Chromatography, Caprylic Acid Ammonium Sulfate Precipitation, Antigen Affinity method, etc.\nOther names Macrophage colony-stimulating factor 1 receptor; Macrophage colony-stimulating factor 1 receptor; macrophage colony-stimulating factor 1 receptor; CD115 antigen; CSF-1 receptor; FMS proto-oncogene; proto-oncogene c-Fms; macrophage colony stimulating factor I receptor; McDonough feline sarcoma viral (v-fms) oncogene homolog; colony stimulating factor 1 receptor; CSF-1 receptor (EC:126.96.36.199); CSF-1-R; CSF-1R; M-CSF-R; Proto-oncogene c-Fms; CD_antigen: CD115\nStorage, shipping and handling The antibody is shipped at +4 degrees Celsius. Upon receving, freeze at -20. For longer periods of time we recommend keeping the vial frozen at -40 or -80. Avoid cycles of freezing and thawing as they may denaturate the polypeptide chains of the antibody. Due to transportation or handling reasons, small amounts of the antibody might get caught on the lid or walls of the vial. We recommend you to briefly cetrifuge the vial prior to use to gather the content on the bottom.\nDescription This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.Antibody for research use.The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.", "domain": "chemistry", "round": 3} +{"url": "https://biosoil.com/former-chemical-laundries/", "date": "2020-11-24T15:09:15Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-50/segments/1606141176864.5/warc/CC-MAIN-20201124140942-20201124170942-00648.warc.gz", "language_score": 0.9362895488739014, "token_count": 396, "dump": "CC-MAIN-2020-50", "global_id": "webtext-fineweb__CC-MAIN-2020-50__0__6467260", "lang": "en", "text": "(Former) chemical laundries\nLast century, chemical laundries made extensive use of chlorinated solvents such as perchloroethylene and trichlorethene. These operations were often located near water or in urban areas. The resulting contamination is mobile and highly biodegradable. We encounter many situations with a highly contaminated source zone and a considerable plume of degradation products, such as dichlorethenes and vinyl chloride. The solvents used are heavier than water and can easily sink to lower depths and form a sinking layer on a poorly permeable bottom formation.\nOur customers are frequently problem owners, developers, foundations and engineering firms, or public authorities. We develop our remediation plans based on the customer’s needs. The basis of our approach is, in most cases, biodegradation. This process is sustainable and can strongly inhibit any adverse effects on surrounding areas because the degradation occurs in the soil on site. If any DNAPL is present on site, it is effectively eliminated by the in-situ system, while excavation sometimes constitutes part of our approach. Introduction of our electron donor allows anaerobic degradation of the contaminant to occur in the soil. Various techniques are applied, such as direct injection and circulation, possibly supplemented by inoculation and incubation of the soil. Introducing the electron donor in soil optimises degradation conditions. We monitor the process ourselves so that we can promptly make any necessary correction to our in-situ remediation.\nIn situ remediation measures enable us to effectively eliminate contaminants from former laundry sites that are sited under gardens and homes, for example. We can flexibly provide services that are in line with customer expectations.\nThe total solution company\nfor soil remediation\nThe Biosoil bioscreen is highly suitable for plume containment at:\n(Petrochemical) industrial site | Petrol station | Waste management facilities and landfills | Urban areas | Natural reserves", "domain": "chemistry", "round": 3} +{"url": "https://freshthinking.cellohealth.com/post/102ezw9/phosphatase-inhibitors-the-next-big-thing-in-small-molecule-therapies", "date": "2022-08-14T11:46:23Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882572033.91/warc/CC-MAIN-20220814113403-20220814143403-00646.warc.gz", "language_score": 0.9548603892326355, "token_count": 477, "dump": "CC-MAIN-2022-33", "global_id": "webtext-fineweb__CC-MAIN-2022-33__0__70208835", "lang": "en", "text": "Phosphorylation and dephosphorylation, the addition or removal of a phosphate \"tag\" to a protein, is a common mechanism by which cells mediate enzyme-driven functions. Many cellular processes are regulated by networks of kinases (which add phosphate molecules) and phosphatases (which remove them), with the result that their enzyme substrates may change their activity, location, or their association with other proteins based on their phosphorylation status. Phosphorylation is crucial to many key pathways, including cell division, and up to two thirds of the proteome may be regulated by phosphorylation.\nAccordingly, selective kinase inhibitors (particularly tyrosine kinase inhibitors, or TKIs) have been an important component of the pharmaceutical arsenal for nearly 20 years, especially in oncology, where they have revolutionised therapy of many leukaemias, lymphomas and some solid cancers such as EGFR-positive NSCLC.\nHowever phosphatases, the flip side of phosphorylation - have been a much harder target. To date, selective phosphatase inhibitors have been largely out of reach, and phosphatases have therefore been considered generally \"undruggable\". But recently the MRC in Cambridge have developed a \"phosphatase inhibitor array\" - a panel of immobilised drugs which are screened for their phosphatase-binding properties. Using this array, they have identified a molecule which binds specifically to PPP1R15B, a phosphatase implicated in Huntingtons' disease. This new drug candidate, Raphin1, has shown encouraging results in vitro, and in vivo, published in the latest issue of Cell.\nObviously one positive animal trial is no guarantee of a successful therapy, but the technology behind it may open up a whole new class of drugs. Together kinases and phosphatases represent the accelerator and brakes of the proteome. This new technology may offer much finer control of many cellular processes, accelerating us towards a new era for proteomic therapies.\n“For decades, with no way to selectively target phosphatases, research into them has lagged behind kinases and they’ve been described as undruggable. Our new system is only a first step, but we hope cracking this problem will stimulate phosphatase research and drug development.", "domain": "chemistry", "round": 3} +{"url": "https://link.springer.com/article/10.1007%2FBF00218860", "date": "2017-05-29T04:17:26Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-22/segments/1495463612013.52/warc/CC-MAIN-20170529034049-20170529054049-00024.warc.gz", "language_score": 0.8739476799964905, "token_count": 394, "dump": "CC-MAIN-2017-22", "global_id": "webtext-fineweb__CC-MAIN-2017-22__0__61480112", "lang": "en", "text": "Development of Xenopus laevis skin glands producing 5-hydroxytryptamine and caerulein\n- Cite this article as:\n- Seki, T., Kikuyama, S. & Yanaihara, N. Cell Tissue Res. (1989) 258: 483. doi:10.1007/BF00218860\nThe granular glands in Xenopus laevis skin are known to contain large quantities of biogenic amines and bioactive peptides which closely resemble mammalian brain-gut peptides. We studied the development of glands producing 5-hydroxytryptamine (5-HT) and caerulein using immunohistochemistry, HPLC-fluorometric systems and RIA. The immunoreactivities of 5-HT and caerulein were first detected in the spherical gland rudiments in the stratum spongiosum at St. 58 (Nieuwkoop and Faber stage), or at the beginning of metamorphosis. Both immunoreactivities appeared in the same rudiment at the same time. Some of the gland rudiments have a small lumen filled with both immunoreactive materials at St. 58–59. During the rest of the metamorphic period, the glands grow in size, accumulating immunoreactive materials in the lumen. The concentrations of 5-HT and caerulein in the skin of tadpoles were below 1 ng per mg wet tissue at St. 58–59, increased as metamorphosis proceeded and reached 63 and 134 ng per mg wet tissue at St. 66, or at the end of metamorphosis, respectively. The amphibian granular glands where large quantities of biogenic amines and hormone-like peptides are rapidly synthesized may provide a useful model for the study of the development of amine- and peptide-producing cells including neurons and paraneurons.", "domain": "chemistry", "round": 3} +{"url": "http://paleohacks.com/questions/97334/betaine-hydrochloride-hcl-causing-side-effects", "date": "2013-05-26T09:07:45Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2013-20/segments/1368706794379/warc/CC-MAIN-20130516121954-00074-ip-10-60-113-184.ec2.internal.warc.gz", "language_score": 0.9843853116035461, "token_count": 353, "dump": "CC-MAIN-2013-20", "global_id": "webtext-fineweb__CC-MAIN-2013-20__0__90626808", "lang": "en", "text": "I've had the same kind of thing, but the betaine-HCL/oxbile combo did such a great job, and since I don't have a gall bladder I really need the stuff.\nThe trick is that pre-paleo, having taken OTC PPIs, my stomach wasn't producing enough acid, so it didn't use as many minerals. When the betaine-HCL and oxbile was introduced (Now Super Enzymes), it now could, and started to cause problems such as even worse acid reflux (which was temporary), and then intolerance to egg whites, and even twitching.\nBut in a few weeks, after also supplementing potassium and magnesium, it's as if the whole system adjusted and became a smooth running machine. I also discovered it wasn't just wheat that was causing my reflux, but also cow dairy.\nSo you might find it takes time to adjust, but when you do, you'll feel much better than you did before.\nThe twitching is absolutely associated with magnesium, so supplement. I don't bother with potassium anymore since the caps are all limited at 99mg and you get a lot more from food, but modern foods lack magnesium due to poor soil. (I suppose that explains my coffee/100% baking chocolate addiction - these two are high in magnesium, though it's bound by phytates.)\nI suspect that betaine HCL and friends kick starts broken stomach acid, which in turn requires more magnesium (and other minerals, hence the side effects) - it's not so much that betaine HCL causes side effects as rather you're depleted, but you don't notice it until you use up more from the increased stomach acid.", "domain": "chemistry", "round": 3} +{"url": "https://kuvapalvelu.net/tuote/pale-blue-li-ion-rechargeable-aa-battery/", "date": "2023-03-26T08:46:04Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-14/segments/1679296945440.67/warc/CC-MAIN-20230326075911-20230326105911-00294.warc.gz", "language_score": 0.7585232853889465, "token_count": 522, "dump": "CC-MAIN-2023-14", "global_id": "webtext-fineweb__CC-MAIN-2023-14__0__112786183", "lang": "en", "text": "Pale Blue Li-Ion Rechargeable AA Battery\nA different kind of rechargeable battery.\nWith our advanced lithium rechargeable technology, Pale Blue batteries charge 5x faster than conventional Ni-MH rechargeable batteries. Pale Blue batteries provide higher power and more consistent output through their use cycle.\n– Fast Charging Lithium Battery: 1000+ Charge Cycles\n– Convenient Micro USB Charge Port: Just plug any micro USB cable or use the included cable to charge four batteries at once.\n– Built-In LED Charging Indicator: Pale Blue Batteries let you know when they are fully charged.\n– On-Board Smart Technology Provides Safe Charging: No more batteries ruining expensive electronic devices!\n– 4 x Pale Blue AA batteries\n– 1 charging cable for simultaneous charging\n– Chemistry: Lithium Ion\n– Power [W-h]: 2.25 Watt hours\n– Voltage: 1.5V\n– Capacity: 1560 mAh\n– Charge Time: Under 2 hours (depending on charger specifications)\n– Cycle Rating: 1000+ Cycles\n– Charging Cable: USB to 4 Micro USB\n– Charge State Indicator: Red Green LED\n– Protection Circuit: Integrated safety circuit protects battery and device\n– Overheat Protection: Operating at max output the battery will not overheat, this is part of the protection circuit.\n– Other Safety Protections: Protects against Overload, Leakage, Short Circuit, Over Voltage, & High Temperature\n– Certifications: IEC 62133, CE, FCC, PSE, UN38.3, RoHS, REACH\n– Operating Temperature Rage: -20c -> 60c, (-4F-> 140F)\n– Self-Discharge: The dormant / self discharge characteristics of Pale Blue batteries are very low. This is one of the advantages of a lithium ion battery with a control circuit, vs an alkaline or NiMh battery, where the cell discharges directly into the circuit (no control circuit). The battery life in dormant mode depends partly on the environment. High ambient temperatures, and higher humidity, increases the internal drain. But in normal circumstances a battery installed in a device, like a door lock, will last ~12 months.\n– Cells Per Battery: 1\n– Lithium Content: 0.165g\n– Individual Battery Weight: 17.5g\nTuotearvioita ei vielä ole.", "domain": "chemistry", "round": 3} +{"url": "https://www.thestar.com.my/search?q=ammonia%20gas&qsort=relevance&qtag=1%2C74", "date": "2022-05-27T06:06:25Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-21/segments/1652662636717.74/warc/CC-MAIN-20220527050925-20220527080925-00548.warc.gz", "language_score": 0.9852539300918579, "token_count": 312, "dump": "CC-MAIN-2022-21", "global_id": "webtext-fineweb__CC-MAIN-2022-21__0__232303761", "lang": "en", "text": "You have searched for \"ammonia gas\"\nShowing 1-10 of 40\nPETALING JAYA: Twenty-seven workers were exposed to ammonia gas when a leak occurred at an ice factory in Shah Alam, the Health Ministry confirmed.\nPASIR PUTEH: Residents in Semerak here have been confirmed safe from an ammonia gas leak at a nearby ice factory Friday.\nMEXICO CITY (Reuters) - At least three people were killed by an ammonia gas leak from a pipeline owned by state oil monopoly Pemex in southern Mexico on Tuesday and 1,500 people were evacuated from the area and taken to shelters, the company said.\nSHAH ALAM (Bernama): The Selangor government has ordered an ice factory located next to SMJK (C) Chong Hwa near here to be moved to a more suitable location away from residential areas and schools.\nSHAH ALAM: Two workers have died and 18 others were hurt after they were believed to have inhaled ammonia gas which leaked at a ice factory in Section 36 here Monday.\nKULIM: A police report has been lodged against an ice factory owner following an ammonia gas leak at the factory on Thursday night.\nSHAH ALAM (Bernama): An inspection by the Shah Alam City Council (MBSA) at an ice factory in Section 36 here, where ammonia gas had leaked earlier, found that the premises had a licence to carry out ice processing activities, but was not permitted to store hazardous materials.", "domain": "chemistry", "round": 3} +{"url": "https://www.heatandplumb.com/blog/how-to-remove-limescale-from-taps", "date": "2023-06-08T11:57:16Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-23/segments/1685224654871.97/warc/CC-MAIN-20230608103815-20230608133815-00008.warc.gz", "language_score": 0.954565167427063, "token_count": 1064, "dump": "CC-MAIN-2023-23", "global_id": "webtext-fineweb__CC-MAIN-2023-23__0__248999995", "lang": "en", "text": "Limescale, or as it's scientifically known “calcium carbonate”, is a common sight in kitchens and bathrooms around Britain, particularly in the southeast. Limescale is more prevalent in areas with hard water (water that has a high mineral content). Hard water is usually caused by water passing through areas with limestone, hence the resulting residue being referred to as limescale. While hard water is very unlikely to have any negative health effects, certainly in the concentration found in your drinking water, it can have a much worse impact on your plumbing.\nWhen hard water is left on a surface and evaporates, it leaves behind its mineral content. This usually takes the form of a chalky white residue: limescale. Though initially harmless, limescale becomes very hard as it dries and, unfortunately, builds more rapidly in areas with existing limescale, compounding the problem. This means that places in your property that are frequently exposed to water, such as taps, shower heads, kettles and drains can become homes for limescale if not quickly dealt with. A more scientific explanation of limescale can be found at Wikipedia. Over time, heavy deposits of limescale can inhibit your plumbing's ability to function or even create blockages. Other unpleasant side effects include finding flakes of limescale in your tea or coffee, having built up on the metallic element inside your kettle. While there are now some shower heads designed to be rubbed clean to prevent limescale blockages, items such as taps will usually require some extra effort.\nFortunately, it's very easy to remove limescale by using harmless household products. While it's possible to remove limescale by scrubbing, tools such as wire wool and abrasive cleaners will probably result in damage to the very items you're looking to protect. By instead applying slightly acidic fluid, you can break limescale apart and gently wipe it away. There are a number of limescale removers on the market, such as HG Professional Limescale Remover and Viakal Original Descaler Liquid, which will be effective for removing build-up in areas such as pipes.\nFor home cleaning and preventing heavy build-up, however, there are plenty of alternative solutions to your limescale problem. The most popular among these are vinegar and lemon juice, both of which can be easily acquired from your local supermarket. Lemon juice can be bought bottled (or simply squeezed from lemons, if you can't find it prepared). If your limescale is too tough for regular vinegar or lemon juice, pickling vinegar or lime juice are a little stronger and should make a bigger impact, even if your bathroom smells of pickles for a day or two.\nWhile it should be straightforward to find a fluid that removes limescale, you might have more difficulty keeping the solution on your metal while it breaks down the limescale. It takes time for these fluids to do their work, usually at least an hour, and most modern bathroom surfaces are designed to make liquids slide away, not stay in place.\nOne trick is to use cotton wool pads, the same type as you might use with facial cleanser. Soak the pads in your cleaning solution and then wrap them around the problem areas on your taps. You can hold the pads in place with strong tape or string, just as long as they stay in contact with the taps. Once this is done, leave your homemade cleaning pads in place for at least an hour, probably closer to two, then remove them. The limescale should now be weakened enough to be wiped away, or at least be vulnerable to being scrubbed off with a scourer. If you're able to remove most of the scale but some still remains, simply repeat the process and you should be able to get the remainder. If you squeeze your own lemon or lime juice to remove limescale, another trick is to take the leftover halves of the fruit and simply stick them onto the ends of your tap spouts.\nLemon juice or vinegar can also be used to clean other items in your home that have been affected by limescale. You can place a cup of either fluid into an empty washing machine or dishwasher and run a cleaning cycle, helping remove or reduce limescale buildup within the machine's workings. Filling your kettle enough with enough fluid to submerge the metal element inside, then topping it up with water and boiling it should remove most of the limescale that inevitably appears in kettles throughout much of the UK. Just be sure to rinse your kettle well afterwards; once you've weakened the limescale, you don't want flakes of it pouring into your morning tea or coffee.\nIf these methods are ineffective, your limescale problem will likely need solving with a specialised cleaning product, which can be found at most large DIY suppliers. These products should remove all but the oldest, most stubborn limescale if you follow the instructions, but it's especially important to rinse kettles and taps properly to remove any toxic residue. Once you have removed this limescale, our guide on Cleaning Chrome in your Bathroom will get your taps looking nice and shiny!", "domain": "chemistry", "round": 3} +{"url": "https://svedruziclab.github.io/principal-investigator.html", "date": "2022-05-19T20:47:00Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-21/segments/1652662530066.45/warc/CC-MAIN-20220519204127-20220519234127-00755.warc.gz", "language_score": 0.6796375513076782, "token_count": 4078, "dump": "CC-MAIN-2022-21", "global_id": "webtext-fineweb__CC-MAIN-2022-21__0__236225505", "lang": "en", "text": "Principal Investigator Name: Željko Svedružić\nInternational Spelling: Zeljko M. Svedruzic\nE-mail: zeljko.svedruzic-at-biotech.uniri.hr (more, including social networks)\nPostal Address: Radmile Matejčić 2, University Campus Trsat, HR-51000 Rijeka, Croatia (on OpenStreetMap)\nOffice: 8th floor, room number 823\nPhone Number: +385-51-584-575\n- Development of mechanism-based inhibitors of mammalian/human DNA methyltransferases with IC50 values below 50 nM. The most successful inhibitors can be used for control of the functional organization of the mammalian genome in research laboratories, biotechnology, and ultimately in clinics for the treatment of pathogenic mechanisms related to epigenetic processes (i.e. tissue regeneration, oncogenesis, psychiatric and neurological disorders, viral infections, immunological disorders).\n- Development of novel bivalent mechanism-based inhibitors of membrane-embedded protease γ-secretase. The most successful compounds can be used for treatment and early diagnosis of Alzheimer’s disease, or for control of different physiological processes that depend on cell-to-cell communication. Paid consultant for the pharmaceutical industry, γ-secretase modulators, and assays.\nDevelopment and commercialization of inhibitors and modulators of human DNA methyltransferase Dnmt1 and membrane-embedded protease γ-secretase.\nMajor accomplishments and perspective\nThe enzymatic mechanism, regulation, and novel drug design strategies.\nPresent research work: Development of mechanism-based inhibitors of mammalian/human DNA methyltransferases.\nMembrane-embedded protease γ-secretase\nThe enzymatic mechanism, regulation, and novel drug-design and early diagnostic strategies for Alzheimer’s disease.\nPresent research work: Development of novel bivalent mechanism-based inhibitors of membrane-embedded protease γ-secretase.\nSubstrate channeling in transient protein-protein interactions. Further research work in perspective.\nOn an ongoing basis: molecular modeling and numerical methods in biomedical sciences, i.e. structure and function of biomolecules, enzyme kinetics, and protein-ligand interactions. Courses presently taught:\nCourses formerly taught:\n- Physical organic and computational chemistry (master level, 2015/2016).\n- Mentoring individual students in research and thesis preparation.\n- Invited lectures: molecular mechanisms in Alzheimer’s disease or molecular mechanisms in epigenetics.\nMolecular mechanisms in epigenetics and chromatin organization; molecular mechanisms in Alzheimer’s disease; protein-protein and protein-ligand interactions; assay-development and drug-design based on enzyme structure-function principles; substrate channeling.\nEnzymology: in vitro, in vivo, and in silico approaches for studies of structure and function of biomolecules.\nBiochemistry, physical biochemistry (i.e. biophysics), medicinal chemistry, bioorganic chemistry, molecular genetics, biological membranes, medical biochemistry, cell biology.\n- Position: Assistant Professor\n- Position: Adjunct Senior Research and Teaching Assistant\nPsychiatry Hospital Rab (2010 – 2013)\n- Position: Supervisor of Laboratory for Medical Biochemistry\nSenior scientist appointments\n- Project: DNA damage-induced changes in DNA flexibility and DNA-nucleosome interaction. DNA repair in nuclear extracts.\n- Project Leader: Regents Professor Michael J. Smerdon\n- Project: Enzymology and inhibitors of mammalian and bacterial cytosine DNA methyltransferases.\n- Project Leader: Professor Norbert O. Reich\n- Project: Enzymology of protein phosphatase CDC25B with Cdk2/CycA protein complex as the substrate (Cdk2 = cycline dependent kinase 2; CycA = cyclin A).\n- Project Leader: Asisstant Professor Johannes Rudolph\n- Ph.D. Thesis Title: Substrate Channeling between NAD(H) Dehydrogenases: Enzyme Kinetics, Protein-Protein Interaction, and Molecular Modeling Studies.\n- Mentor: Professor H. Olin Spivey (deceased)\nMax Planck Institute of Biochemistry (1992 – 1993)\n- Master Thesis Title: Purification of p17 protein; a component of Actin-Myosin complex from Dictyostelium discoideum.\n- Mentor: Emeritus Günther Gerisch\n- Undergraduate studies in biochemistry and molecular biology.\n- Gielnik, M., Taube, M., Zhukova, L., Zhukov, I., Wärmländer, S. K. T. S., Svedružić, Ž., Kwiatek, W. M., Gräslund, A., and Kozak, M. Zn(II) binding causes interdomain changes in the structure and flexibility of the human prion protein. Nature Scientific Reports 11, 21703 (2021). PDF\n- Chaudhary, H., Iashchishyn, I. A., Romanova, N. V., Rambaran, M. A., Musteikyte, G., Smirnovas, V., Holmboe, M., Ohlin, C. A., Svedružić, Ž. M., and Morozova-Roche, L. A.. Polyoxometalates as Effective Nano-inhibitors of Amyloid Aggregation of Pro-inflammatory S100A9 Protein Involved in Neurodegenerative Diseases. ACS Applied Materials & Interfaces 13(23), 26721-26734 (2021). PDF\n- Leri M., Chaudhary H., Iashchishyn, I. A., Pansieri, J., Svedružić, Ž. M., Alcalde, S. G., Musteikyte, G., Smirnovas, V., Stefani, M., Bucciantini, M., and Morozova-Roche, L. A., Natural Compound from Olive Oil Inhibits S100A9 Amyloid Formation and Cytotoxicity: Implications for Preventing Alzheimer’s Disease. ACS Chemical Neuroscience 12(11), 1905-1918 (2021). PDF\n- Svedružić, Ž. M., Vrbnjak, K., Martinović, M., and Miletić, V. Structural Analysis of the Simultaneous Activation and Inhibition of γ-Secretase Activity in the Development of Drugs for Alzheimer’s Disease. Pharmaceutics 13(4), 514, April 8th (2021). PDF\n- Svedružić, Ž. M., Odorčić, I., Chang, C. H., and Svedružić, D. Substrate Channeling via a Transient Protein-Protein Complex: The case of D-Glyceraldehyde-3-Phosphate Dehydrogenase and L-Lactate Dehydrogenase. Sci. Rep. 10, 10404, June 26th (2020). PDF, PubMed\n- Pansieri, J., Ostojić, L., Iashchishyn, I. A., Magzoub, M., Wallin, C., Wärmländer, S. K. T. S., Gräslund, A., Nguyen Ngoc, M., Smirnovas, V., Svedružić, Ž., and Morozova-Roche, L. A., Pro-Inflammatory S100A9 Protein Aggregation Promoted by NCAM1 Peptide Constructs. ACS Chem. Biol. 14, 1410–1417 (2019). PDF, PubMed\n- Miletić, V., Odorčić, I., Nikolić, P., and Svedružić, Ž. M. In silico design of the first DNA-independent mechanism-based inhibitor of mammalian DNA methyltransferase Dnmt1. PLoS One 12(4), April 11th (2017). PDF, PubMed\n- Svedružić, Ž. M., Popović, K., and Šendula-Jengić, V. Decrease in catalytic capacity of γ-secretase can facilitate pathogenesis in sporadic and Familial Alzheimer’s disease. Molecular and Cellular Neuroscience 67, July 31st (2015). PDF\n- Svedružić, Ž. M., Popović, K., and Šendula-Jengić, V. Modulators of γ-secretase activity can facilitate the toxic side-effects and pathogenesis of Alzheimer’s disease. PLoS One 8(1), January 7th (2013). PubMed\n- Svedružić, Ž. M. Popović, K., Smoljan, I., and Šendula-Jengić, V. Modulation of γ-secretase activity by multiple enzyme-substrate interactions: Implications in pathogenesis of Alzheimer’s disease. PLoS One 7(3), March 30th (2012). PubMed\n- Svedružić, Ž. M. Mammalian Cytosine DNA methyltransferase Dnmt1: Enzymatic Mechanism, Novel Mechanism-Based Inhibitors, and RNA-directed DNA methylation. Current Medicinal Chemistry 15(1), 92–106 (2008). PubMed, PDF\n- Svedružić, Ž. M. and Spivey, H. O. Interaction between Mammalian Glyceraldehyde-3-phosphate Dehydrogenase and L-Lactate Dehydrogenase from Heart and Muscle. Proteins, Structure, Function, and Bioinformatics 63(3), 501–511 (2006). PubMed, PDF\n- Svedružić, Ž. M., Wang, C., Kosmoski, J. V., and Smerdon, M. J. Accommodation and Repair of a UV Photoproduct in DNA at Different Rotational Settings on the Nucleosome Surface. Journal of Biological Chemistry 280(48), 40051–40057 (2005). PubMed\n- Svedružić, Ž. M. and Reich, N. O. The Mechanism of Allosteric Regulation of Dnmt1’s Processivity. Biochemistry 44(45), 14972–14988 (2005). PubMed, PDF\n- Svedružić, Ž. M. and Reich, N. O. DNA Cytosine C5 Methyltransferase Dnmt1: Catalysis Dependent Release of Allosteric Inhibition. Biochemistry 44(27), 9472–9485 (2005).\n- Svedružić, Ž. M. and Reich, N. O. The Mechanism of Target Base Attack in DNA Cytosine C5 Methylation. Biochemistry 43(36), 11460–11473 (2004).\n- Lehoux E. A., Svedružić, Ž., and Spivey, H. O. Determination of Specific Radioactivity of [14C] Lactate by Enzymatic Decarboxylation and CO2 Collection. Analytical Biochemistry 253(2), 190–195 (1997).\n- Rokić, F., Trgovec-Greif, L., Sučić, N., Čemeljić, N., Cekinović Grbeša, Đ., Svedružić, Ž., Rukavina, T., Vugrek, T., and Jurak, I. Diverse SARS-CoV-2 variants preceded the initial COVID-19 outbreak in Croatia. Arch. Virol., March 24th (2021). PDF, PubMed\n- Nikolić P., Miletić V., and Svedružić, Ž. M. DNA Methyltransferase Dnmt1: Regulation of Substrate Selectivity. In 6th OEGMBT Annual Meeting 2014 Abstract Book, edited by Alexandra Khassidov, Walter Glaser, and Christoph Klimek, 129. Vienna, Austria: Austrian Association of Molecular Life Sciences; Biotechnology; Servicebetrieb ÖH-Uni Graz GmbH. (2014).\n- Svedružić, Ž. M. and Reich, N. O. Enzymatic properties of mouse cytosine DNA methyltransferase DNMT1. Abstracts of Papers of the American Chemical Society 223:C75. (2002).\n- Nikolić, P., Miletić, V., Odorčić, I., and Svedružić, Ž. M. (2016). In Silico Optimization of the First DNA-Independent Mechanism-Based Inhibitor of Mammalian DNA Methyltransferase DNMT1. In: Epi-Informatics, (Boston: Academic Press), pp. 113–153. PDF\n- Svedružić, Ž. M. Mammalian DNA methyltransferase Dnmt1: Structure and Function. In: Modification of Mammalian DNA: Mechanism, Management, Missions, and Medical Implications. Progress in Molecular Biology and Translational Science 101, 221–254 (Elsevier, 2011). PubMed, PDF\n- Svedružić, Ž. M., Nikolić, P., Miletić, V., and Odorčić, I. Substrate-lock mechanism controls de novo methylation by mammalian DNA methyltransferase Dnmt1.\n- Svedružić, Ž. M., Popović, K., and Šendula-Jengić, V. The basic enzymology of modulation of γ-secretase activity: identification of the key pharmacophoric groups.\n- Svedružić, Ž. M. A flexible loop and two charged amino acids regulate formation and break-up of transient catalytic complex between protein phosphatase CDC25B and Cdk2/Cycline-A heterodimer.\n- Professor Bart de Strooper, KU Leuven\n- Regents Professor Michael J. Smerdon, Washington State University\n- Professor Norbert O. Reich, University of California Santa Barbara\n- Ludmilla Morozova-Roche, Umeå University\nAd hoc reviewer\n- DNA Repair, Elsevier\n- Epigenetics, Taylor & Francis Group (formerly Landes Bioscience)\n- Biochemical Journal, Biochemical Society\n- Bioorganic & Medicinal Chemistry Letters, Elsevier\n- Journal of Neuroscience, Society for Neuroscience\n- Biochimie, Elsevier\n- Current Medicinal Chemistry, Bentham Science\n- WebmedCentral Biochemistry\n- 248th ACS National Meeting and Exposition. ChemEpInformatics: In the Pursuit of Epidrugs Using Chemoinformatics and Computational Approaches, August 10–14, 2014, San Francisco, CA, USA. DNA methyltransferase Dnmt1: Regulation and novel drug-design strategies.\n- EuroSciCon: Alzheimer’s Drug Discovery and Development, June 25, 2014, London, UK. Modulators of γ-secretase activity can facilitate the toxic side-effects and pathogenesis of Alzheimer’s disease.\n- Ruder Bošković Institute, May 23, 2013, Zagreb, Croatia. Alzheimerova bolest iz molekularne perspektive: patogeneza, rana dijagnostika i razvoj novih lijekova.\n- 4th Croatian Congress on Side Effects of Psychopharmacs, March 29–31 2012, Osijek, Croatia. Side effects of antipsychotics: how to avoid them and how can they be useful.\nPublic talks and popular lectures\n- European Researchers’ Night 2019 in Rijeka, Tower Center, September 27, 2019, Rijeka, Croatia.\n- European Researchers’ Night 2018 in Rijeka, Tower Center, September 28, 2018, Rijeka, Croatia. Mikroskop vs. superračunala u farmaciji (superračunala kao mikroskopi 21. stoljeća).\n- Društvo za promociju znanosti i kritičkog mišljenja, June 13, 2014, Rijeka, Croatia. Epigenetika i utjecaj epigenetike na ljudsko ponašanje, zdravlje i budućnost medicine: prvi dio (predavanje) i drugi dio (Q&A).\n- European Researchers’ Night 2013 in Rijeka, September 27, 2013, Rijeka, Croatia.\n- Psychiatric Hospital Rab, Internacionalna škola iz psihijatrije i kognitivne neuroznanosti, October 4–5, 2012, Rab, Croatia. Strah od znanosti i tehnologije u doba globalne ekonomske krize.\n- Psychiatric Hospital Rab, Tjedan mozga, March 4–5, 2012, Rab, Croatia. Geni, ljudsko ponašanje i kako praviti nove lijekove\n- Psychiatric Hospital Rab, Tjedan mozga, March 11–20, 2011, Rab, Croatia. Morbus Alzheimer - može li se spriječiti i kako liječiti\n- Conferences: almost 20 years of active participation in professional meetings and conferences.\n- Teaching: almost 20 years of active direct and indirect mentoring of junior colleagues in research laboratories.\nMy name is pronounced as Zhelko Svedruzhich, with zh pronounced as letters asu in words like: treasure, pleasure, measure.\nMy name appears on papers in different forms. Some of them are Svedruzic, ZM, Svedruzic, Z. M., Svedružić, ŽM, and Svedružić, Ž. M. Name will appear with or without Croatian accents depending on the publication.", "domain": "chemistry", "round": 3} +{"url": "https://neurophotonics.ca/design-and-mechanistic-insight-ultrafast-calcium-indicators-monitoring-intracellular-calcium", "date": "2018-12-12T07:56:09Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-51/segments/1544376823785.24/warc/CC-MAIN-20181212065445-20181212090945-00365.warc.gz", "language_score": 0.7493370771408081, "token_count": 414, "dump": "CC-MAIN-2018-51", "global_id": "webtext-fineweb__CC-MAIN-2018-51__0__94829733", "lang": "en", "text": "|Title||Design and mechanistic insight into ultrafast calcium indicators for monitoring intracellular calcium dynamics.|\n|Publication Type||Journal Article|\n|Year of Publication||2016|\n|Authors||Helassa, Nordine, Borbala Podor, Alan Fine, and Katalin Török|\n|Date Published||2016 Dec 06|\nCalmodulin-based genetically encoded fluorescent calcium indicators (GCaMP-s) are powerful tools of imaging calcium dynamics from cells to freely moving animals. High affinity indicators with slow kinetics however distort the temporal profile of calcium transients. Here we report the development of reduced affinity ultrafast variants of GCaMP6s and GCaMP6f. We hypothesized that GCaMP-s have a common kinetic mechanism with a rate-limiting process in the interaction of the RS20 peptide and calcium-calmodulin. Therefore we targeted specific residues in the binding interface by rational design generating improved indicators with GCaMP6fu displaying fluorescence rise and decay times (t1/2) of 1 and 3 ms (37 °C) in vitro, 9 and 22-fold faster than GCaMP6f respectively. In HEK293T cells, GCaMP6fu revealed a 4-fold faster decay of ATP-evoked intracellular calcium transients than GCaMP6f. Stimulation of hippocampal CA1 pyramidal neurons with five action potentials fired at 100 Hz resulted in a single dendritic calcium transient with a 2-fold faster rise and 7-fold faster decay time (t1/2 of 40 ms) than GCaMP6f, indicating that tracking high frequency action potentials may be limited by calcium dynamics. We propose that the design strategy used for generating GCaMP6fu is applicable for the acceleration of the response kinetics of GCaMP-type calcium indicators.\n|Alternate Journal||Sci Rep|\n|PubMed Central ID||PMC5138832|", "domain": "chemistry", "round": 3} +{"url": "http://www.research.lancs.ac.uk/portal/en/publications/genetic-structure-and-regulation-of-isoprene-synthase-in-poplar-populus-spp(80e9ff82-f8e2-4dc1-89ae-31f06f081e43).html", "date": "2017-04-25T14:43:01Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-17/segments/1492917120461.7/warc/CC-MAIN-20170423031200-00016-ip-10-145-167-34.ec2.internal.warc.gz", "language_score": 0.9061121940612793, "token_count": 327, "dump": "CC-MAIN-2017-17", "global_id": "webtext-fineweb__CC-MAIN-2017-17__0__189309949", "lang": "en", "text": "Research output: Contribution to journal › Journal article\n|Journal publication date||07/2010|\n|Journal||Plant Molecular Biology|\n|Number of pages||12|\nIsoprene is a volatile 5-carbon hydrocarbon derived from the chloroplastic methylerythritol 2-C-methyl-d-erythritol 4-phosphate isoprenoid pathway. In plants, isoprene emission is controlled by the enzyme isoprene synthase; however, there is still relatively little known about the genetics and regulation of this enzyme. Isoprene synthase gene structure was analysed in three poplar species. It was found that genes encoding stromal isoprene synthase exist as a small gene family, the members of which encode virtually identical proteins and are differentially regulated. Accumulation of isoprene synthase protein is developmentally regulated, but does not differ between sun and shade leaves and does not increase when heat stress is applied. Our data suggest that, in mature leaves, isoprene emission rates are primarily determined by substrate (dimethylallyl diphosphate, DMADP) availability. In immature leaves, where isoprene synthase levels are variable, emission levels are also influenced by the amount of isoprene synthase protein. No thylakoid isoforms could be identified in Populus alba or in Salix babylonica. Together, these data show that control of isoprene emission at the genetic level is far more complicated than previously assumed.", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/recombinant-human-wdsub1-protein-ab165627.html", "date": "2018-09-21T14:42:30Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-39/segments/1537267157203.39/warc/CC-MAIN-20180921131727-20180921152127-00296.warc.gz", "language_score": 0.7819260954856873, "token_count": 341, "dump": "CC-MAIN-2018-39", "global_id": "webtext-fineweb__CC-MAIN-2018-39__0__83028918", "lang": "en", "text": "The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\nProtein concentration is above or equal to 0.05 mg/ml.\nConcentration information loading...\nPreparation and Storage\nStability and Storage\nShipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.\npH: 8.00 Constituents: 0.31% Glutathione, 0.79% Tris HCl\nWD repeat, SAM and U box domain containing protein 1\nWD repeat, SAM and U-box domain containing 1\nWD repeat, sterile alpha motif and U box domain containing 1\nWD repeat-containing proteins are those that contain 4 or more copies of the WD-repeat (tryptophan-aspartate repeat), a sequence motif approximately 31 amino acids long, that encodes a structural repeat. There are two isoforms of WDSUB1.\nSDS-PAGE - Recombinant Human WDSUB1 protein (ab165627)\nab165627 on a 12.5% SDS-PAGE stained with Coomassie Blue.\nhas not yet been referenced specifically in any publications.\nPublishing research using ab165627? Please let us know so that we can cite the reference in this datasheet.\nCustomer reviews and Q&As\nPlease note: All products are \"FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE\"\nGet resources and offers direct to your inboxSign up", "domain": "chemistry", "round": 3} +{"url": "http://earthdoc.eage.org/publication/publicationdetails/?publication=91834", "date": "2019-11-20T11:58:30Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-47/segments/1573496670558.91/warc/CC-MAIN-20191120111249-20191120135249-00407.warc.gz", "language_score": 0.8738533854484558, "token_count": 448, "dump": "CC-MAIN-2019-47", "global_id": "webtext-fineweb__CC-MAIN-2019-47__0__107700454", "lang": "en", "text": "GEOLOGY AND GEOPHYSISC TO DISCOVER Cu-Zn MINERALIZATION IN PURWOHARDJO AREA, WONOGIRI REGENCY, CENTRAL JAVA\nV.P. Harefa, R.A. Hidayah, B.B. Prabowo, D. Aminulloh and R.A.M. Yudha\nEvent name: EAGE-HAGI 1st Asia Pacific Meeting on Near Surface Geoscience and Engineering\nSession: Poster session\nPublication date: 09 April 2018\nInfo: Extended abstract, PDF ( 353.83Kb )\nPrice: € 20\nThe research is located in Central Java Province, Wonogiri Regency, Karangtengah-Purwohardjo Area. The lithology unit in the research area consists of volcanic breccia units, which are intruded sequentially by the pyroxene andesite, and the dacite. The geological structure of the shear and fracture faults participates in controlling the mineralization in the research area. Based on interconnected relationships in the field, the dacite is interpreted as a mineralization-bearing intrusion. Hydrothermal alteration includes argillic and propylitic alteration. The argillic alteration zones are characterized by the presence of sericite minerals, chlorite and clay minerals, which are generally intensively formed on pyroxene andesite and dacite. The propylitic alteration zones are characterized by the presence of chlorite, epidote and calcite minerals, which are commonly found in volcanic and partly andesitic breccias. Hydothermal alteration is strongly associated with ore mineralization. The copper ore sulfide minerals are chalcopyrite, bornite with a bit of kalkosit and kovelit. In Induced Polarization profiles the Trend value of high chargeability appears to be related to the presence of metal sulphide minerals in andesite and dacite rocks. Based on the characteristics of alteration and mineralization and from Geophysiscs interpretation, the research area is included in High Sulfidation Epithermal related to Porphiry type.", "domain": "chemistry", "round": 3} +{"url": "http://www.ask.com/web?q=Chart+of+Endocrine+Hormones&o=2603&l=dir&qsrc=3139&gc=1", "date": "2016-08-31T17:37:17Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2016-36/segments/1471982295966.49/warc/CC-MAIN-20160823195815-00033-ip-10-153-172-175.ec2.internal.warc.gz", "language_score": 0.7682418823242188, "token_count": 328, "dump": "CC-MAIN-2016-36", "global_id": "webtext-fineweb__CC-MAIN-2016-36__0__149768106", "lang": "en", "text": "Endorine Glands are important parts of the endocrine system of the human body.\nThis IvyRose Revision page about the endocrine system is intended for ...\nThe endocrine system is a control system of ductless glands that secrete ... There\nare two types of hormones secreted in the endocrine system: Steroidal and ...\nHormones Chart - Free download as Word Doc (.doc / .docx), PDF File (.pdf), Text\n... A chart of the main hormones in the endocrine system, their function, target ...\nThis system is comprised of several major endocrine glands. These glands\nsecrete hormones into the blood. Once in the blood, the hormones travel along\nHORMONE GLAND ORIGIN TARGET TISSUE FUNCTION ... The Endocrine\nSystem: Function and Structure | Online Homework Help | SchoolWorkHelper ...\nAug 10, 2016 ... Our nervous system uses electrical impulses, the endocrine system uses\nchemicals called hormones. Hormones usually work more slowly than ...\nThis page reviews, in chart form, the information you should have accumulated\non the primary hormones secreted by each endocrine gland and the effects of ...\nhormones. • Name the major endocrine glands, and identify their locations. •\nDiscuss the control of glandular secretion by nervous mechanisms, hormonal.\nEndocrine System Flow Chart | the chemical classes of hormones include amines\npolypeptides ... | See more about Endocrine System, Charts and Chapter 16.\nDetailed information on hormones and their role in the workings of the endocrine", "domain": "chemistry", "round": 3} +{"url": "https://innspub.net/isolation-and-characterization-of-arsenic-resistant-bacteria-isolated-from-industrial-wastewater-of-pakistan-region-and-bacterial-biomass-bioremediation-activity-in-arsenic-bioremediation/", "date": "2023-12-02T04:59:29Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100327.70/warc/CC-MAIN-20231202042052-20231202072052-00879.warc.gz", "language_score": 0.6768980026245117, "token_count": 1121, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__226887021", "lang": "en", "text": "Isolation and characterization of arsenic resistant bacteria, isolated from industrial wastewater of Pakistan region and bacterial biomass bioremediation activity in arsenic bioremediation\nDey U, Chatterjee S, Mondal NK. 2016. Isolation and characterization of arsenic-resistant bacteria and possible application in bioremediation. Biological reports 10, 1-7.\nJames C, Natalia S. 2014. Microbiology. A labortory manual: Pearson Education.\nKoechler S, Cleiss-Arnold J, Proux C, Sismeiro O, Dillies MA, Goulhen-Chollet, F, Hommais F, Lièvremont D, Arsène-Ploetze F, Coppée JY. 2010. Multiple controls affect arsenite oxidase gene expression in Herminiimonas arsenicoxydans. BMC microbiology 10, 53-55.\nLi X, Zhang L, Wang G. 2014. Genomic evidence reveals the extreme diversity and wide distribution of the arsenic-related genes in Burkholderiales. PloS one 3, e99236.\nManzoor M, Abid R, Rathinasabapathi B, De-Oliveira LM, Da-Silva E, Deng F, Rensing C, Arshad M, Gul I, Xiang P. 2019. Metal tolerance of arsenic-resistant bacteria and their ability to promote plant growth of Pteris vittata in Pb-contaminated soil. Science of the Total Environment 660, 18-24.\nMohanty D. 2017. Conventional as well as emerging arsenic removal technologies—a critical review. Water, Air, & Soil Pollution 10, 381.\nMondal M, Biswas JK, Tsang YF, Sarkar B, Sarkar D, Rai M, Sarkar SK, Hooda PS. 2019. A wastewater bacterium Bacillus sp. KUJM2 acts as an agent for remediation of potentially toxic elements and promoter of plant (Lens culinaris) growth. Chemosphere 232, 439-452.\nMujawar SY, Shamim K, Vaigankar DC, Dubey SK. 2019. Arsenite biotransformation and bioaccumulation by Klebsiella pneumoniae strain SSSW7 possessing arsenite oxidase (aioA) gene. BioMetals 1, 65-76.\nMuller D, Lievremont D, Simeonova DD, Hubert JC, Lett MC. 2003. Arsenite oxidase aox genes from a metal-resistant β-proteobacterium. Journal of bacteriology 185, 135-141.\nNaureen A, Rehman A. 2016. Arsenite oxidizing multiple metal resistant bacteria isolated from industrial effluent: their potential use in wastewater treatment. World Journal of Microbiology and Biotechnology 8, 133.\nNg KS, Ujang Z, Le-Clech P. 2004. Arsenic removal technologies for drinking water treatment. Reviews in Environmental Science and Biotechnology 3, 43-53.\nOremland RS, Stolz JF. 2003. The ecology of arsenic. Science 300, 939-944.\nPrasad KS, Ramanathan AL, Paul J, Subramanian V, Prasad R. 2013. Biosorption of arsenite (As+ 3) and arsenate (As+ 5) from aqueous solution by Arthrobacter sp. Biomass. Environmental technology 19, 2701-2708.\nQin J, Rosen B, Zhang Y, Wang G, Franke S, Rensing C. 2006. Arsenic detoxification and evolution of trimethylarsine gas by a microbial arsenite S-adenosylmethionine methyltransferase. Proceedings of the National Academy of Sciences 7, 2075-2080.\nRosen BP. 2002. Biochemistry of arsenic detoxification. FEBS letters 529, 86-92.\nSher S, Rehman A. 2019. Use of heavy metals resistant bacteria—a strategy for arsenic bioremediation. Applied microbiology and biotechnology 103, 6007-6021.\nSher S, Rehman A, Hansen LH, NielsenTK. 2019. Complete Genome Sequences of Highly Arsenite-Resistant Bacteria Brevibacterium sp. Strain CS2 and Micrococcus luteus AS2. Microbiology resource announcements 8, e00531-19.\nSmith AH, Lingas EO, Rahman M. 2000. Contamination of drinking-water by arsenic in Bangladesh: a public health emergency. Bulletin of the World Health Organization 78, 1093-1103.\nTariq A, Ullah U, Asif M, Sadiq I. 2019. Biosorption of arsenic through bacteria isolated from Pakistan. International Microbiology 22, 59-68.\nZhang Y, Chen S, Hao X, Su J, Xue X, Yan Y, Zhu YG, Ye J. 2016. Transcriptomic analysis reveals adaptive responses of an enterobacteriaceae strain LSJC7 to arsenic exposure. Frontiers in Microbiology 7, http://dx.doi.org/10.3389/fmicb.2016.00636", "domain": "chemistry", "round": 3} +{"url": "https://www.net-a-porter.com/ca/en/product/348926/Ellis_Faas/creamy-lips---l104-deep-fuchsia", "date": "2019-01-22T12:51:54Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-04/segments/1547583850393.61/warc/CC-MAIN-20190122120040-20190122142040-00410.warc.gz", "language_score": 0.7124165296554565, "token_count": 405, "dump": "CC-MAIN-2019-04", "global_id": "webtext-fineweb__CC-MAIN-2019-04__0__219855910", "lang": "en", "text": "- Turn the rotating base to release Creamy Lips formula into the sponge\n- Apply Creamy Lips first by painting the lips with just a small amount of lipstick\n- Then fully load the applicator to fill inside of the lips\n- 2.8ml/0.095 fl.oz.\nIngredients: Hydrogenated Polydecene, Isododecane, Hydrogenated Styrene/Isoprene Copolymer, Polyethylene, Disteardimonium Hectorite, Propylene Carbonate, Octyldodecanol, Dicalcium Phosphate, Candelilla Cera, Prunus Domestica Seed Extract, Ethylhexyl Palmitate, Tribehenin, Tocopherol, Ascorbyl Palmitate, Sorbitan Isostearate, Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate, Palmitoyl Oligopeptide.+/- May Contain: Mica, Ci 77891 (Titanium Dioxide), Ci 77491/77492/77499 (Iron Oxides), Ci 75470 (Carmine), Red 7, Ci 15850 (Red 6/Red 7 Lake), Ci 73360 (Red 30 Lake), Ci 45410 (Red 28 Lake), Ci 45380 (Red 22 Lake), Ci 42090 (Blue 1 Lake), Ci 19140 (Yellow 5 Lake), Ci 15985 (Yellow 6 Lake)\nA shocking pink pout is a runway favourite. Achieve the look yourself with makeup artist Ellis Faas' glide-on lip color. Applying a light layer before blotting with a tissue will give a delicate fuchsia stain, or the color can be built up for a bolder look.\n- Plumping actives improve hydration and smooth your lips\n- Contains anti-oxidant Vitamin E\n- Also available in: Ellis Red, Pale Peach", "domain": "chemistry", "round": 3} +{"url": "https://obuhov.info/portugal/problems-associated-with-the-techniques-of-radiocarbon-dating-94605.php", "date": "2021-10-23T05:32:06Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-43/segments/1634323585561.4/warc/CC-MAIN-20211023033857-20211023063857-00077.warc.gz", "language_score": 0.9686269164085388, "token_count": 617, "dump": "CC-MAIN-2021-43", "global_id": "webtext-fineweb__CC-MAIN-2021-43__0__61845105", "lang": "en", "text": "An Indian text commonly referred to as The Bakhshali Manuscript is documented as the oldest record of the concept of zero and it was believed to be originally from the 9th century. Radiocarbon dating is a technique used by archaeologists to determine the approximate age of an artifact and or ecofact. It is the most common and reliable absolute dating technique. Researchers were able to use radiocarbon dating on The Bakhshali Manuscript because it was made out of birch bark, an organic material. However, it was difficult to determine the true age of The Bakhshali Manuscript because the 70 page document is composed of materials from three different time periods. When the University of Oxford tested the document with their Radiocarbon Accelerator Unit they used three different samples and each sample came from a different century.\nRadiocarbon dating is one of the best known archaeological dating techniques available to scientists, and the many people in the general public have at least heard of it. But there are many misconceptions about how radiocarbon works and how reliable a technique it is. Radiocarbon dating was invented in the s by the American chemist Willard F. Libby and a few of his students at the University of Chicago: in , he won a Nobel Prize in Chemistry for the invention. It was the first absolute scientific method ever invented: that is to say, the technique was the first to allow a researcher to determine how long ago an organic object died, whether it is in context or not. Shy of a date stamp on an object, it is still the best and most accurate of dating techniques devised.\nRadiocarbon Dating: A Closer Look At Its Main Flaws\nThe field of radiocarbon dating has become a technical one far removed from the naive simplicity which characterized its initial introduction by Libby in the late 's. It is, therefore, not surprising that many misconceptions about what radiocarbon can or cannot do and what it has or has not shown are prevalent among creationists and evolutionists - lay people as well as scientists not directly involved in this field. In the following article, some of the most common misunderstandings regarding radiocarbon dating are addressed, and corrective, up-to-date scientific creationist thought is provided where appropriate.\nA publication of the Archaeological Institute of America. Since the s , biogeochemist Richard Evershed of the University of Bristol has been trying to find a way to accurately radiocarbon date ceramic artifacts. But it has taken nearly three decades for technology to catch up with his vision. Archaeologists have been using pottery styles to date artifacts and sites for decades, but these dates had to be confirmed using methods such as radiocarbon dating of associated materials or dendrochronology, the analysis of tree rings. His team is able to isolate compounds from samples of pottery that weigh as little as two grams and to detect the minuscule amount of fatty-acid carbon remaining in the residues left by milk, cheese, or meat.", "domain": "chemistry", "round": 3} +{"url": "http://www.newton.dep.anl.gov/askasci/phy00/phy00699.htm", "date": "2015-01-30T04:53:50Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2015-06/segments/1422115858583.14/warc/CC-MAIN-20150124161058-00159-ip-10-180-212-252.ec2.internal.warc.gz", "language_score": 0.9372125267982483, "token_count": 335, "dump": "CC-MAIN-2015-06", "global_id": "webtext-fineweb__CC-MAIN-2015-06__0__91891166", "lang": "en", "text": "Largest Z Number\nName: Hassan A.\nPlease, I would like to know The largest possible atomic number Z predicted by\ntheoretical physics. I would like to know why this value of Z, if known, represents the upper\natomic number ?\nThe largest stable Z is 92, Uranium. It is radioactive with a half life of several billion\nyears. Nuclei with higher Z (more protons) are unstable and generally decay quickly, though\nneptunium has a half life of several million years.\nThe basic reason why higher Z nuclei are not stable is that protons are positively charged and\nrepel each other. The nuclear force holds them (and the neutrons) together, but the coulomb\nforce of repulsion finally becomes decisive.\nUranium contains more neutrons (143), which do not repel one another electrically, but nuclei\nwith more neutrons are also unstable due to quantum mechanical effects which are difficult to\nexplain. It is like adding electrons to atoms as Z increases; the first are in low energy\norbits, but as more are added (they cannot go into the same state due to the Pauli Exclusion\nPrinciple) they are in higher energy states. In the nucleus, additional neutrons are put in\nhigher energy states until they have too high energy to be bound. If you try to add a 144th\nneutron to uranium, it will not stick.\nBest, Richard J. Plano Professor of Physics emeritus, Rutgers University\nClick here to return to the Physics Archives\nUpdate: June 2012", "domain": "chemistry", "round": 3} +{"url": "http://www.lithiumprimarybattery.com/china-safety_heat_meter_required_2800mah_high_power_lithium_thionyl_chloride_cell_li_socl2_battery-8501433.html", "date": "2021-11-27T17:00:21Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-49/segments/1637964358208.31/warc/CC-MAIN-20211127163427-20211127193427-00501.warc.gz", "language_score": 0.8161851763725281, "token_count": 797, "dump": "CC-MAIN-2021-49", "global_id": "webtext-fineweb__CC-MAIN-2021-49__0__169010873", "lang": "en", "text": "Payment & Shipping Terms:\n|Sealing Type:||Hermetic Sealing||Storage Life:||More Than 10 Years At Room Temperature|\n|Storage Temperature:||≤30℃||Storage Humidity:||≤75%RH|\nLithium Thionyl Chloride Battery,\nhigh capacity lithium batteries\nSafety Heat Meter Required 2800mAh High Power Lithium Thionyl Chloride Cell Li-SOCl2 Battery\n|Battery discharged at continuous current 5.4mA until voltage reaches cut-off voltage 2.0V at ambient temperature 23±2℃|\n|Nominal Voltage||3.6 V|\n|Maximum Continuous Current||540mA|\n|Battery with minimum 50% rated capacity discharged at ambient temperature 23±2℃|\n|Maximum Pulse Discharge Current||1080mA|\n|Battery with minimum 50% rated capacity discharged at max pulse for 3 seconds after 27seconds break. Ambient temperature 23±2℃|\nTemperature ≤ 30℃\nHumidity ≤ 75%RH\n|Operating Temperature||-55℃ to +85℃|\n|Battery Dimension||See drawing on pag|\n|Max self-discharged rate at ambient temperature 23±2℃|\n|Shelf Life||10 years|\n|Ambient temperature 23±2℃|\n1. Battery Characteristic\nWe offer the nominal voltage up to 3.6V, the working voltage varies with the load, generally between 3.3V ~ 3.6V\nWe provide the specific energy density up to 403Wh/kg\nThe battery with a strong adaptability to temperature can be in work between -55℃ ~ +85℃\nStable operating voltage, more than 90% of the capacity could be output with a fixed voltage\nUnder the condition of normal temperature, the battery self -discharge rate of no more than 2% per year\nHermetic welding sealing to reduce the leakage for extending the shelf life to more than 10 years\n2. Main Applications\nWireless telecommunication devices\nAutomatic meters (water meter, electric meter, gas meter), conventional meters, etc.\nRFID products, GPS tracking, asset tracking, road toll transponder, IC cards, etc.\n3. Manufacturing Advantages\n4. Company Advantages\n5. FAQS of General Safety Instructions\nWhen the abnormal heat release or leakage occurs, the battery is not able to be continued to use.\nThe manual should be read before the battery is used.\nThe battery should be kept out of the children firstly. If swallowed by children, please contact a physician at once.\nYou need to follow the signs + and - on the batteries and make sure not to reverse. If batteries are wrongly used, they will be hot very fast and can lead the gas and other toxic materials leakage.\nThey are going to be hot in very short time and it will lead the leakage of gas and toxic materials which may cause a big rupture.\nIf + and - polarity of battery is connected directly, it causes a short circuit and this may lead toxic gas and materials leakage or a big rupture.\nThe batteries can not be soldered directly. If they are directly soldered, it will cause short circuit and a gas and toxic material leakage or big rupture.\nContact Person: Angela", "domain": "chemistry", "round": 3} +{"url": "https://dubstepper.ru/carbon-dating-on-man-made-objects-678.html", "date": "2021-05-09T19:58:47Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-21/segments/1620243989012.26/warc/CC-MAIN-20210509183309-20210509213309-00514.warc.gz", "language_score": 0.9351032376289368, "token_count": 377, "dump": "CC-MAIN-2021-21", "global_id": "webtext-fineweb__CC-MAIN-2021-21__0__154191255", "lang": "en", "text": "Carbon dating on man made objects 2016 cso issued policies 2016 backdating\nOther labs accept waterlogged wood while others prefer them dry at submission.2.\nSample collection Contaminants must not be introduced to the samples during collection and storing.\nWhen a living thing dies, it stops interacting with the biosphere, and the carbon 14 in it remains unaffected by the biosphere but will naturally undergo decay.\nDecay of carbon 14 takes thousands of years, and it is this wonder of nature that forms the basis of radiocarbon dating and made this carbon 14 analysis a powerful tool in revealing the past.\nBut archaeology’s aim to understand mankind is a noble endeavor that goes beyond uncovering buried treasures, gathering information, and dating events.\nIt is in knowing what made past cultures cease to exist that could provide the key in making sure that history does not repeat itself.\nAn archaeologist must also make sure that only the useful series of samples are collected and processed for carbon dating and not every organic material found in the excavation site.\nIt is important that the radiocarbon scientists and archaeologists agree on the sampling strategy before starting the excavation so time, effort, and resources will not be wasted and meaningful result will be produced after the carbon dating process.Historians can tell what cultures thrived in different regions and when they disintegrated.Anthropologists can describe a people’s physical character, culture, and environmental and social relations.Carbon 14 dating remains to be a powerful, dependable and widely applicable technique that is invaluable to archaeologists and other scientists.The unstable and radioactive carbon 14, called radiocarbon, is a naturally occurring isotope of the element carbon.Sample storage Samples must be stored in packaging materials that will protect them during transport and even during prolonged storage.Tags: Adult Dating, affair dating, sex dating", "domain": "chemistry", "round": 3} +{"url": "http://www.aquariumline.com/catalog/oceanlife-buffer-p-17630.html?language=en", "date": "2017-10-21T08:13:58Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-43/segments/1508187824675.67/warc/CC-MAIN-20171021081004-20171021101004-00179.warc.gz", "language_score": 0.9111481308937073, "token_count": 484, "dump": "CC-MAIN-2017-43", "global_id": "webtext-fineweb__CC-MAIN-2017-43__0__52774844", "lang": "en", "text": "Product: OceanLife KH Buffer 1L\nThe Berliner bases its success on the use of live rock , strong lighting, abundant water movement and filtration entrusted to a skimmer . In this way it creates an environment that simulates what happens in the natural reef , or the removal of pollutants by surface- skimmer and a reduction in non-polar compounds pollutants by live rocks (which are home to an internal collection of microorganisms able to complete the nitrogen cycle ) .\nCalcium and carbonates are used by all the animals of the aquarium for the formation of aragonite , material component the skeleton of corals , the shells of bivalves such as clams , crustacean shells etc ...\nBesides the intrinsic importance of these factors, it is important to be present in water in definite proportions . The salts are commercial balanced mixtures of a multitude of salts , present in a balanced way , it happens , however, that there may be unbalanced consumption of calcium or carbonates , due to micro- precipitation or other factors.\nKH Carbonate Buffer brings in the most concentrated form possible. Take a few grams to increase the value of KH in a remarkable. Thanks to this characteristic , it is suitable for large tanks .\nIts use is similar to that of Liquid KH Plus , but has a greater power of reinstatement . It is therefore more difficult to dose in small tanks , since small quantities may vary the level of KH too quickly .\nKH Buffer , as well as Liquid KH Plus and CA + KH Part B , is devoid of Borates . This is because the continuous use could lead to an accumulation of boron . This situation is to be avoided. This element , in fact , is consumed with a lower speed than the carbonates. And ' necessary to separately control the level of boron and correct it if necessary through the use of Oceanlife Boron.\nThese products do not alter the values of nitrates, phosphates, silicates and are free of chelating agents, preservatives and gluconates .\n1 ml of KH buffer in 90 liters of water increase the value of the carbonates of 1 dKH . In the case in which the KH should be increased more than one degree , dilute the dose over several days , so as to increase not more than 1-2 dKH / day .", "domain": "chemistry", "round": 3} +{"url": "http://kettlebenefit.com/16-descaling-tablets-kettle-descaler-coffee-machine-descaler-limescale-remover-for-decalcifying-multiple-appliances-kettles-irons-water-filters-coffee-machines-4-boxes-of-4-16-total/", "date": "2018-01-23T13:45:30Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-05/segments/1516084891976.74/warc/CC-MAIN-20180123131643-20180123151643-00699.warc.gz", "language_score": 0.8961682319641113, "token_count": 256, "dump": "CC-MAIN-2018-05", "global_id": "webtext-fineweb__CC-MAIN-2018-05__0__148564670", "lang": "en", "text": "What Are Fizz Tablets?\nFizz Descaling Tablets are a simple and quick to use product for dissolving the limescale (mainly calcium carbonate) that builds up in various appliances that associate with boiled or heated water e.g. include kettles, coffee machines, irons etc.\nHow Do I Use It?\nInstructions are on the packet, but it easily dissolves limescale in a steady and safe manner, whereby the contents can be discarded and washed, or the process repeated to clear very heavy limescale buildup.\nWhy Remove Limescale?\nRemoving limescale is important as it renders your electrical appliances much more efficient by improving their performance and lifetime.\nFizz descaling tablets are suitable for use in most appliances, except those with galvanised surfaces or enamel appliances.\n- ✓ FAST DESCALING of all appliances – Kettle, Coffee Makers, Irons etc…\n- ✓ REMOVES and PREVENTS limescale – Improves appliance performance\n- ✓ ORIGINAL Fizz Descaling Tablets\n- ✓ INCREDIBLY ECONOMICAL\n- ✓ 4 BOXES of 4 Tablets – 16 TABLETS IN total!", "domain": "chemistry", "round": 3} +{"url": "http://pregi.bi.up.ac.za/pre_gi_swbit.php?blast=blastp&query=NC_007086:3334000&subject=NC_008782:1510000", "date": "2019-12-06T08:30:15Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-51/segments/1575540486979.4/warc/CC-MAIN-20191206073120-20191206101120-00386.warc.gz", "language_score": 0.8851727843284607, "token_count": 396, "dump": "CC-MAIN-2019-51", "global_id": "webtext-fineweb__CC-MAIN-2019-51__0__9855056", "lang": "en", "text": "Query: NC_007086:3334000 Xanthomonas campestris pv. campestris str. 8004, complete genome Lineage: Xanthomonas campestris; Xanthomonas; Xanthomonadaceae; Xanthomonadales; Proteobacteria; Bacteria General Information: The original was isolated from an inflected cauliflower in Sussex, United Kingdom, in 1958. Strain 8004 is a spontaneous rifampicin resistant strain. Causes black rot disease in crucifers. These organisms are almost exclusively found associated with their plant hosts and are not found free in the soil. This species is a major cause of black rot in crucifers, a disease that results in massive tissue degeneration. It also produces an extracellular polysaccharide known as xanthan, which is harvested commercially as a food stabilizing agent for use in industry.\n- Sequence; - BLASTP hit: hover for score (Low score = Light, High score = Dark); - hypothetical protein; - cds: hover for description\nGeneral Information: Acidovorax sp. JS42, formerly Pseudomonas sp. JS42, was isolated from nitrobenzene-contaminated sediment and is capable of using 2-nitrotolulene as a sole carbon and energy source. 2-nitrotolulene, a nitroaromatic compound, is used in the manufacture of dyes, pigments and explosives. Nitroaromatic compounds, which contain an aromatic ring with one or more nitro groups attached, are a significant contaminant in industrial soils. Acidovorax sp. JS42 degrades 2-nitrotolulene by first removing the nitro moiety producing 3-methylcatechol. The enzyme involved in this process, 2-nitrotolulene dioxygenase, has been purified and characterized.", "domain": "chemistry", "round": 3} +{"url": "http://www.abcam.com/plxdc2-antibody-ab67226.html", "date": "2018-05-26T10:24:40Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-22/segments/1526794867416.82/warc/CC-MAIN-20180526092847-20180526112847-00462.warc.gz", "language_score": 0.68427973985672, "token_count": 550, "dump": "CC-MAIN-2018-22", "global_id": "webtext-fineweb__CC-MAIN-2018-22__0__126283534", "lang": "en", "text": "For the best experience on the Abcam website please upgrade to a modern browser such as Google Chrome\nRabbit polyclonal to Plxdc2\nMouse, Rat, Human\nA 17 amino acid peptide from near the carboxy terminus of human Plxdc2.\n- Human colon tissue lysate, human brain tissue.\nShipped at 4°C. Store at +4°C.\nPreservative: 0.02% Sodium Azide\nConcentration information loading...\nImmunogen affinity purified\nOur Abpromise guarantee covers the use of\nin the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\n||Use a concentration of 0.5 - 1 µg/ml. Detects a band of approximately 60 kDa (predicted molecular weight: 60 kDa).\n||Use a concentration of 20 µg/ml.\n||Use at an assay dependent concentration.\nMay play a role in tumor angiogenesis.\nExpressed in the endothelial cells of the stroma but not in the endothelial cells of normal colonic tissue.\nBelongs to the plexin family.\nContains 1 PSI domain.\nInformation by UniProt\n- FLJ14623 antibody\n- Plexin domain containing 2 antibody\n- Plexin domain containing protein 2 antibody\nWestern blot - Anti-Plxdc2 antibody (ab67226)\nLane 1 : Anti-Plxdc2 antibody (ab67226) at 0.5 µg/ml\nLane 2 : Anti-Plxdc2 antibody (ab67226) at 1 µg/ml\nAll lanes : human colon tissue lysate\nLysates/proteins at 15 µg per lane.\nPredicted band size: 60 kDa\nObserved band size: 60 kDa\nImmunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Plxdc2 antibody (ab67226)\nThis image shows human brain tissue stained with ab67226 at 2.5µg/ml.\nImmunocytochemistry/ Immunofluorescence-Anti-Plxdc2 antibody(ab67226)\nImmunofluorescence of Plxdc2 in Human Brain cells using ab67226 at 50 ug/ml.\nhas not yet been referenced specifically in any publications.\nPlease note: All products are \"FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE\"", "domain": "chemistry", "round": 3} +{"url": "https://loveparisperfumes.com/the-difference-between-eau-de-toilette-and-eau-de-parfum/", "date": "2022-01-28T21:46:00Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-05/segments/1642320306346.64/warc/CC-MAIN-20220128212503-20220129002503-00044.warc.gz", "language_score": 0.9210553169250488, "token_count": 579, "dump": "CC-MAIN-2022-05", "global_id": "webtext-fineweb__CC-MAIN-2022-05__0__26938030", "lang": "en", "text": "Eau de Parfum, Eau de Toilette: names you have probably seen in the past. But what is the difference between them?\nIn simple terms, the difference comes from the intensity or concentration of the fragrance. A perfumer sometimes combines more than 100 differently scented ingredients. This “mixture” is called a pure perfume or the perfume oil. In order to determine the right strength of the perfume and to ensure safety on the skin, the pur perfume is mixed with a solvent. Perfumers usually use ethanol for this, but they could also use unscented oil or wax. Alcohol is most commonly used as a solvent and is often mixed with a small amount of water. Alcohol makes the product easy to spray, it evaporates quickly and leaves the fragrant components nicely spread on the skin. Furthermore, alcohol has relatively little scent of its own and gives a cooling refreshing effect.\nThe difference between Eau de Toilette and Eau de Parfum\nBased on the amount of pure perfume, we can determine the name of a perfume. For example, an Eau Fraiche contains the minimum concentration of perfume oil, followed by Eau de Cologne.\nEau de Toilette has been the most common strength for fragrances for years. An Eau de Toilette is nice for everyday use, because this formula is frequently lighter. Depending on the quality and structure of the fragrance, you can still enjoy it for quite some time. On average, an Eau de Toilette contains somewhere in the range of 5 and 10% of perfume oil.\nIf you choose an Eau de Parfum, you choose a fragrance that is a bit more intense, extravagant and fuller than an Eau de Toilette. As a result, you often enjoy an Eau de Parfum the entire day or even night! Most Eau de Parfums contain on average between 10 and 20% perfume oil.\nThe main contrast is therefore the amount of pure perfume in the formula: an Eau de Toilette contains less perfume oil and more water and alcohol than an Eau de Parfum. Depending on what you like as far as the intensity of a fragrance, you can choose an Eau de Toilette or Eau de Parfum.\nIs there a difference in fragrance with the different formulas?\nIt is possible that you see both an Eau de Toilette and an Eau de Parfum of a fragrance, and although the formulas could be identical, they only differ in concentration. For example, the perfumer can add more emphasis on the light-footed and transparent character of the fragrance in the Eau de Toilette, while in the Eau de Parfum, the deeper and exotic elements of the fragrance are more exposed.", "domain": "chemistry", "round": 3} +{"url": "https://supfam.mrc-lmb.cam.ac.uk/SUPERFAMILY/cgi-bin/scop.cgi?sunid=81452", "date": "2023-09-27T15:50:51Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233510300.41/warc/CC-MAIN-20230927135227-20230927165227-00497.warc.gz", "language_score": 0.8811489939689636, "token_count": 370, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__262752393", "lang": "en", "text": "Cytochrome c oxidase is the terminal enzyme of the respiratory chain of mitochondria and many aerobic bacteria. It catalyzes the transfer of electrons from reduced cytochrome c to molecular oxygen:\n4 cytochrome c+2 + 4 H+ + O2 --> 4 cytochrome c+3 + 2 H2O\nThis reaction is coupled to the pumping of four additional protons across the mitochondrial or bacterial membrane [10563795, 16598262].\nCytochrome c oxidase is an oligomeric enzymatic complex that is located in the mitochondrial inner membrane of eukaryotes and in the plasma membrane of aerobic prokaryotes. The core structure of prokaryotic and eukaryotic cytochrome c oxidase contains three common subunits, I, II and III. In prokaryotes, subunits I and III can be fused and a fourth subunit is sometimes found, whereas in eukaryotes there are a variable number of additional small polypeptidic subunits . The functional role of subunit III is not yet understood.\nAs the bacterial respiratory systems are branched, they have a number of distinct terminal oxidases, rather than the single cytochrome c oxidase present in the eukaryotic mitochondrial systems. Although the cytochrome o oxidases do not catalyze the cytochrome c but the quinol (ubiquinol) oxidation they belong to the same haem-copper oxidase superfamily as cytochrome c oxidases. Members of this family share sequence similarities in all three core subunits: subunit I is the most conserved subunit, whereas subunit II is the least conserved [1316894, 2162835, 8083153].", "domain": "chemistry", "round": 3} +{"url": "https://www.organicvapesandbuds.com/product/buy-live-resin-online-live-resin-information-buy-live-resin-canada-buy-live-resin-in-bulk-buy-live-resin-online-can-ada-live-resin-concertrate/", "date": "2020-08-13T06:19:23Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-34/segments/1596439738960.69/warc/CC-MAIN-20200813043927-20200813073927-00574.warc.gz", "language_score": 0.901184618473053, "token_count": 511, "dump": "CC-MAIN-2020-34", "global_id": "webtext-fineweb__CC-MAIN-2020-34__0__51458746", "lang": "en", "text": "Buy Live Resin online – Live Resin Information- buy Live Resin canada-buy Live Resin in bulk-buy Live Resin online canada-Live Resin concertrate\nLive resin is a type of cannabis concentrate that is manufactured using a technique that takes freshly harvested cannabis and freezes it to subcritical temperatures prior to and throughout the extraction process. Where these methods differ from other extraction processes is in the amount of time harvested cannabis plants are allowed to dry and cure before the extraction.Live Resin Information- buy Live Resin canada-buy Live Resin in bulk-buy Live Resin online canada-Live Resin concertrate\nThe drying and curing process that a cannabis plant typically undergoes can have a devastating impact on terpenes, the flavorful factory molecules present within the trichomes that line virtually every corner of a mature cannabis flower and its surrounding foliage. With cured concentrates, the cannabis plant is allowed a certain amount of time to wick itself of moisture and chlorophyll before the extraction occurs. During this time, trichomes are subjected to conditions not conducive to terpene preservation. Interactions such as increased exposure to heat, oxygen, physical agitation, and light all play a role in degrading terpenes.\nGetting up close and personal with a fully mature, living cannabis plant is somewhat of a transcendent experience. The bouquet of aromas captured in a single sniff off a living bud will completely redefine your expectations of the relationship between cannabis flowers and their many complex fragrances. However, facilitating a translation of these distinct flavors and aromas into a consumable product is easier said than done. Live Resin Information- buy Live Resin canada-buy Live Resin in bulk-buy Live Resin online canada-Live Resin concertrate\nOnce a cannabis plant has been harvested, the myriad of intermediary processes between when the shears touch the stalk and when you consume the final product has the potential to all but completely eliminate those valuable flavors and aromas. To add fuel to the fire, many cannabis extraction techniques intentionally purge these elements, leaving the consumer with an odorless concentrate completely void of the “essence” it once carried.Live Resin Information- buy Live Resin canada-buy Live Resin in bulk-Live Resin concertrate\nHow is it possible to capture the flavors and aromas from a living plant and bring that experience to the cannabis consumer? The answer is with “live resin” concentrates.", "domain": "chemistry", "round": 3} +{"url": "https://soshrimp.com/crystal-red-shrimp-sss-grade/", "date": "2023-10-02T11:00:46Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233510994.61/warc/CC-MAIN-20231002100910-20231002130910-00028.warc.gz", "language_score": 0.9283112287521362, "token_count": 344, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__184902450", "lang": "en", "text": "Keeping Crystal Red Shrimp (CRS) requires specific water parameters and conditions, as they are sensitive and require stable and consistent conditions to thrive. Here are some of the requirements to keep CRS:\nWater parameters: CRS require a pH range of 6.0-6.8, a water hardness between 4-6 gH and a low Total Dissolved Solids (TDS) level of around 120-150 ppm. It is recommended to use a TDS meter to monitor and maintain stable water conditions.\nAquarium setup: CRS are sensitive to fluctuations in water parameters, so it is important to maintain a stable and consistent environment. A planted aquarium with shrimp substrate is recommended, along with some hiding places and a few floating plants for shade and cover.\nFiltration: A gentle sponge filter or a hang-on-back filter with a pre-filter sponge is recommended to maintain water quality and provide adequate water flow.\nWater changes: Regular water changes are important for maintaining stable water parameters and removing accumulated pollutants. A 10-20% water change every week is recommended.\nFeeding: CRS are omnivorous and will feed on a variety of foods, including algae wafers, shrimp pellets, blanched vegetables, and specialized shrimp food. A varied diet is important for maintaining their health and vitality.\nAvoid copper: CRS are sensitive to copper and other heavy metals, which can be harmful or even fatal to them. Ensure that any equipment or supplements used in the aquarium are copper-free.\nAvoid medication: Certain medications and chemicals can be harmful to CRS, so it is important to research and avoid any treatments that may be harmful to them.", "domain": "chemistry", "round": 3} +{"url": "https://pqdtopen.proquest.com/doc/1784199565.html?FMT=ABS", "date": "2021-03-07T23:37:13Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-10/segments/1614178381230.99/warc/CC-MAIN-20210307231028-20210308021028-00572.warc.gz", "language_score": 0.9417836666107178, "token_count": 700, "dump": "CC-MAIN-2021-10", "global_id": "webtext-fineweb__CC-MAIN-2021-10__0__149402727", "lang": "en", "text": "Populations of federally-listed gopher tortoises (Gopherus polyphemus) are in decline in Mississippi. Soil and forage quality may be linked to their health and recruitment. To gain a better understanding of existing soil and forage quality conditions on areas inhabited by gopher tortoises, I investigated soil chemistry parameters, forage nutrients, and plant community characteristics from 2012 to 2013. These parameters were collected on 7 soil and habitat management treatment types in uplands on public forest lands in south Mississippi. Soil sample analyses indicated that most pH levels in soils were acidic (pH < 5.0) to strongly acidic (pH < 4.5). Greatest soil calcium levels were detected on growing season burn, moderately suitable soil areas, and soil phosphorus levels were greatest on mowed, less suitable soil areas. Greatest levels of nutrients were detected at 0–10 cm soil depths. Weak, positive associations were detected between soil pH and soil calcium and magnesium levels, while weak, negative associations were detected between soil pH and soil phosphorus levels. Greater levels of calcium, magnesium, and phosphorus were detected in plants collected in mowed, less suitable soil areas. Cacti, forbs and, legumes were found to have greatest nutrient levels of all the plant growth forms. Moderate, positive associations were detected between soil pH and calcium levels in legumes and vines. Weak, positive associations were detected between soil pH and forage calcium levels in forbs and native grasses. Very weak, positive associations were detected between soil pH and forage phosphorus levels in vines. I found greatest species richness and percent coverage of legumes and forbs on moderately suitable soils that received growing season fire; whereas, greater species richness and percent coverage of native grasses were detected on moderately suitable soil regardless of season of burn. Greatest percent coverage of cacti (Opuntia sp.) and greatest quantities of above-ground plant biomass were detected on mowed, less suitable soil areas. This information can be valuable to habitat evaluation and management for gopher tortoises.\n|Advisor:||Jones, Jeanne C.|\n|School:||Mississippi State University|\n|School Location:||United States -- Mississippi|\n|Source:||DAI-B 81/1(E), Dissertation Abstracts International|\n|Subjects:||Soil sciences, Wildlife Management, Nutrition|\n|Keywords:||Metabolic bone disease, Growing season burn, Gopher tortoise, Forage nutrients, Dormant season burn, Soil nutrients, Mississippi|\nCopyright in each Dissertation and Thesis is retained by the author. All Rights Reserved\nThe supplemental file or files you are about to download were provided to ProQuest by the author as part of a\ndissertation or thesis. The supplemental files are provided \"AS IS\" without warranty. ProQuest is not responsible for the\ncontent, format or impact on the supplemental file(s) on our system. in some cases, the file type may be unknown or\nmay be a .exe file. We recommend caution as you open such files.\nCopyright of the original materials contained in the supplemental file is retained by the author and your access to the\nsupplemental files is subject to the ProQuest Terms and Conditions of use.\nDepending on the size of the file(s) you are downloading, the system may take some time to download them. Please be", "domain": "chemistry", "round": 3} +{"url": "https://cipsm.de/publications/research-area-c/spt4-5-stimulates-transcription-elongation-through-the-rna-polymerase-clamp-coiled-coil-motif/", "date": "2024-04-15T03:15:08Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712296816939.51/warc/CC-MAIN-20240415014252-20240415044252-00297.warc.gz", "language_score": 0.894565761089325, "token_count": 320, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__6823640", "lang": "en", "text": "Spt4/5 stimulates transcription elongation through the RNA polymerase clamp coiled-coil motif\nNucleic Acids Research, 2010, doi: 10.1093/nar/gkq135, 4040–4051 published on 02.03.2010\nSpt5 is the only known RNA polymerase-associated factor that is conserved in all three domains of life. We have solved the structure of the Methanococcus jannaschii Spt4/5 complex by X-ray crystallography, and characterized its function and interaction with the archaeal RNAP in a wholly recombinant in vitro transcription system. Archaeal Spt4 and Spt5 form a stable complex that associates with RNAP independently of the DNA–RNA scaffold of the elongation complex. The association of Spt4/5 with RNAP results in a stimulation of transcription processivity, both in the absence and the presence of the non-template strand. A domain deletion analysis reveals the molecular anatomy of Spt4/5 the Spt5 Nus-G N-terminal (NGN) domain is the effector domain of the complex that both mediates the interaction with RNAP and is essential for its elongation activity. Using a mutagenesis approach, we have identified a hydrophobic pocket on the Spt5 NGN domain as binding site for RNAP, and recipro- cally the RNAP clamp coiled-coil motif as binding site for Spt4/5.", "domain": "chemistry", "round": 3} +{"url": "https://www.creative-diagnostics.com/Anti-AKT1-MAb-160035-144.htm", "date": "2018-08-20T18:13:37Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-34/segments/1534221216724.69/warc/CC-MAIN-20180820180043-20180820200043-00367.warc.gz", "language_score": 0.7040532231330872, "token_count": 547, "dump": "CC-MAIN-2018-34", "global_id": "webtext-fineweb__CC-MAIN-2018-34__0__87951254", "lang": "en", "text": "Anti-AKT1 monoclonal antibody (DCABH-59)\nMouse Anti-Human AKT1 monoclonal antibody for IP, WB, ELISA, IHC-P\nBring this labeled antibody directly to your bench!\nOnline Inquiry Add to basket\nSynthetic peptide corresponding to residues surrounding the internal sequence amino acid T308 of Human AKT1 protein.\nWB: 1/500 - 1/3000; ELISA: 1/20000; IHC-P: 20 μg/ml;\n*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.\nAKT1; v-akt murine thymoma viral oncogene homolog 1; RAC-alpha serine/threonine-protein kinase; AKT; PKB; PRKBA\nAKT phosphorylates targets in the cytosol, organism-specific biosystem; AKT phosphorylates targets in the nucleus, organism-specific biosystem; AKT-mediated inactivation of FOXO1A, organism-specific biosystem; Activation of BAD and translocation to mitochondria, organism-specific biosystem; Activation of BH3-only proteins, organism-specific biosystem; Acute myeloid leukemia, organism-specific biosystem; Acute myeloid leukemia, conserved biosystem;\nHave you cited DCABH-59 in a publication? Let us know\nand earn a reward for your research.\nSundstrom, JM; Sundstrom, CJ; et al. Phosphorylation Site Mapping of Endogenous Proteins: A Combined MS and Bioinformatics Approach. JOURNAL OF PROTEOME RESEARCH 8:798-807(2009).\nByun, HJ; Hong, IK; et al. A splice variant of CD99 increases motility and MMP-9 expression of human breast cancer cells through the AKT-, ERK-, and JNK-dependent AP-1 activation signaling pathways. JOURNAL OF BIOLOGICAL CHEMISTRY 281:34833-34847(2006).\nCustom Antibody Labeling\nWe offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody.", "domain": "chemistry", "round": 3} +{"url": "https://corrosion-group.com/zinc-anodes/hull-anodes/", "date": "2023-06-10T04:30:16Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-23/segments/1685224656963.83/warc/CC-MAIN-20230610030340-20230610060340-00119.warc.gz", "language_score": 0.7188894152641296, "token_count": 391, "dump": "CC-MAIN-2023-23", "global_id": "webtext-fineweb__CC-MAIN-2023-23__0__217601294", "lang": "en", "text": "Zinc anodes, also known as sacrificial anodes, play a key role in the maintenance of your boat.\nThe term “zincs” has become synonymous with sacrificial anodes, being that zinc was the original material used for this purpose. However, other metals, such as aluminum and magnesium, also work as sacrificial anodes. There are several key factors to be taken into consideration before applying any sacrificial anodes Here is some examples: - Electrolyte (water, soil),- design life, -application area\n|ARTICLE NR||TYPE||WEIGHT kg||A mm||B mm||C mm||D mm||E mm|\nMeasurements of this table are always approximate and can vary over time.\nAlloy: US MIL-A-1800 1 L – Zn", "domain": "chemistry", "round": 3} +{"url": "https://etj.uotechnology.edu.iq/article_175592.html", "date": "2022-11-28T18:03:29Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-49/segments/1669446710534.53/warc/CC-MAIN-20221128171516-20221128201516-00359.warc.gz", "language_score": 0.7710024118423462, "token_count": 2207, "dump": "CC-MAIN-2022-49", "global_id": "webtext-fineweb__CC-MAIN-2022-49__0__9325614", "lang": "en", "text": "Enhancement of the Rutting Resistance of Asphalt Mixtures at Different High Temperatures Using Waste Polyethylene Polymer\nEngineering and Technology Journal,\n2022, Volume 40, Issue 11, Pages 1432-1440\nAbstractThe temperature and stress caused by the load can be cited as two main parameters leading to breakage in asphalt pavement, especially rutting (permanent deformation). So, to reduce the problems of rutting of roads, several actions have been taken, including improving pavement quality and the structure design methods. The increase in the attention of respective engineers in the last few years to modify and improve the asphalt performance through providing different types of additives and replacing the raw materials of asphalt mixture with recycled materials to improve the environment and reduce the cost of modified pavement mixture. This study discussed the use of low-density waste polyethylene as an asphalt modifier in percentages of (2, 4, and 6) % by the weight of asphalt and their impact on the performance of asphalt mixtures at high temperatures. This study showed that using plastic waste (low-density polyethylene) as a bitumen modifier improved the performance of asphalt mixtures at different high temperatures. This was achieved by reducing the rut depth by (80.5) % and (82.3) % at temperatures of 50 C and 60 C, respectively, using low-density polyethylene waste at an optimum value of about 4% by weight of asphalt in addition to enhancing the Marshall stability by using this percentage of polymer.\n- Using low-density polyethylene in asphalt paving enhances the road construction systems and the environment''s protection against pollution.\n- A remarkable improvement in the performance of asphalt paving was achieved using different percentages of low-density polyethylene.\n- The optimum percentage of LDPE additive was verified as 4% by weight of asphalt through all laboratory results (Marshall tests).\n M. Ameri, D. Mirzaiyan, and A. Amini, Rutting resistance and fatigue behavior of gilsonite-modified asphalt binders, Journal of Materials in Civil Engineering, 30 (2018) 04018292.\n A. H. Al-Rubaie and H. H. Joni, Assessment the performance of asphalt mixtures modified with waste tire rubber at high temperatures, in Journal of Physics: Conference Series, 2021.\n D. A. Anderson, D. W. Christensen, H. U. Bahia, R. Dongre, M. Sharma, C. E. Antle, et al., Binder characterization and evaluation, volume 3: Physical characterization, Strategic Highway Research Program, National Research Council, Washington, DC, 1994.\n G. Airey, Styrene butadiene styrene polymer modification of road bitumens, Journal of Materials Science, 39 (2004) 951-959.\n H. Ziari, A. Amini, A. Moniri, and M. Habibpour, Using the GMDH and ANFIS methods for predicting the crack resistance of fibre reinforced high RAP asphalt mixtures, Road Materials and Pavement Design, 2020.\n M. Y. Fattah, M. M. Hilal, and H. B. Flyeh, Assessment of mechanical stability performance of asphalt mixture using Superpave gyratory compactor, Journal of Transportation Engineering, Part B: Pavements, 145 (2019) 04019004.\n A. Amini and R. Imaninasab, Investigating the effectiveness of Vacuum Tower Bottoms for Asphalt Rubber Binder based on performance properties and statistical analysis, Journal of Cleaner Production, 171 (2018) 1101-1110.\n M. Nouali, E. Ghorbel, and Z. Derriche, Phase separation and thermal degradation of plastic bag waste modified bitumen during high temperature storage, Construction and Building Materials, 239 (2020) 117872.\n A. I. Asphalt Institute, Asphalt Mix Design Methods, MS-2, 2014.\n L. Jun, Z. Yuxia, and Z. Yuzhen, The research of GMA-g-LDPE modified Qinhuangdao bitumen, Construction and Building Materials, 22 (2008) 1067-1073.\n A. Al-Hadidy and T. Yi-qiu, Effect of polyethylene on life of flexible pavements, Construction and Building Materials, 23 (2009) 1456-1464.\n A. S. Abbas and F. A. Mohamed, Production and Evaluation of Liquid Hydrocarbon Fuel from Thermal Pyrolysis of Virgin Polyethylene Plastics, Iraqi Journal of Chemical and Petroleum Engineering, 16 (2015) 21-33.\n P. Lastra-González, M. A. Calzada-Pérez, D. Castro-Fresno, Á. Vega-Zamanillo, and I. Indacoechea-Vega, Comparative analysis of the performance of asphalt concretes modified by dry way with polymeric waste, Construction and Building Materials, 112 (2016) 1133-1140.\n S. Fernandes, L. Costa, H. Silva, and J. Oliveira, Effect of incorporating different waste materials in bitumen, Ciência & Tecnologia Dos Materiais, 29 (2017) e204-e209.\n Y. M. E. Aboalmaali, Performance of Modified Asphalt MixtureSuitable for Thin Overlay, Ph.D. thesis, HIGHWAY AND TRANSPORTATION ENGINEERING DEPARTMENT, COLLEGE OF ENGINEERING, MUSTANSIRIYAH UNIVERSITY, Baghdad. Iraq, (2020).\n H. H. Joni, H. H. Zghair, And A. A. Mohammed, Rutting Parameters Of Modified Asphalt Binder With Micro And Nano-Size Of Metakaolin Powder, Journal Of Engineering Science And Technology, 15 (2020) 3465-3480.\n H. H. Zghair, H. H. Joni, and M. S. Hassan, Evaluating The Effects of Micro and Nano Size of Silica Filler on Asphalt Cement Properties, Eng. Technol. J., 38 (2020) 1832-1841.\n C. Fang, R. Yu, Y. Zhang, J. Hu, M. Zhang, and X. Mi, Combined modification of asphalt with polyethylene packaging waste and organophilic montmorillonite, Polymer Testing, 31 (2012) 276-281.\n H. H. Jony, M. M. Hilal, and D. S. Helan, Effect of Polymer Additives on Permeability of Asphalt Concrete Mixtures, Eng. Technol. J., 36 (2018) 75-83.\n L. Brasileiro, F. Moreno-Navarro, R. Tauste-Martínez, J. Matos, and M. d. C. Rubio-Gámez, Reclaimed polymers as asphalt binder modifiers for more sustainable roads: A review, Sustainability, 11 (2019) 646.\n M. Y. Fattah, W. Abdulkhabeer, N., and M. M. Hilal, Characteristics of Asphalt Binder and Mixture Modified With Waste Polypropylene, Eng. Technol. J., 39 (2021) 1224-1230.\n S. Angelone, M. C. Casaux, M. Borghi, and F. O. Martinez, Green pavements: reuse of plastic waste in asphalt mixtures, Materials and Structures,. 49 (2016) 1655-1665.\n M. Attaelmanan, C. P. Feng, and A. Al-Hadidy, Laboratory evaluation of HMA with high density polyethylene as a modifier, Construction and Building Materials, 25 (2011) 2764-2770.\n M. A. Al-Jumaili and H. A. Al-Jameel, Reducing Rutting in Flexible Pavement Using Specified Polymers with HMA, in IOP Conference Series: Materials Science and Engineering, 2020.\n A. H. Abed and H. U. Bahia, Enhancement of permanent deformation resistance of modified asphalt concrete mixtures with nano-high density polyethylene, Construction and Building Materials, 236 (2020) 117604.\n M. S. Ahmad, Low density polyethylene modified dense graded bituminous macadam, International Journal of Engineering Trends and Technology, 16 (2014) 366-372.\n U. J. Nkanga, J. A. Joseph, F. V. Adams, and O. U. Uche, Characterization of bitumen/plastic blends for flexible pavement application, Procedia Manufacturing, 7 (2017) 490-496.\n H. Z. Farahani, M. Palassi, and S. Sadeghpour Galooyak, Thermal analysis of bitumen modified with LDPE and CR, Petroleum Science and Technology, 35 (2017) 1570-1575.\n R. E. SCRB, Standard Specifications for Roads and Bridges., in Section R/9, Hot-Mix Asphaltic Concrete Pavement., ed, 2003.\n M. A. AbdAl-Hussein, Characteristics of Asphalt Binder (Fresh and Aged) Modified with Waste Oils and Plastics, Msc, MSc. thesis, Civil Engineering Department, University of Technology, Baghdad, Iraq, university of technology, 2019.\n T. AASHTO, 324, Hamburg Wheel-Track Testing of compacted Hot Mix Asphalt (HMA), ed: American Association of State Highway and Transportation Officials (AASHTO, 2013).\n B. E. 22, Bituminous Mixtures–Tests Method for Hot Mix Asphalt. Part 22: Wheel Tracking Test., ed, 2003.\n- Article View: 73\n- PDF Download: 54", "domain": "chemistry", "round": 3} +{"url": "https://research.wur.nl/en/publications/water-repellency-and-critical-soil-water-content-in-a-dune-sand", "date": "2021-06-22T04:10:16Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-25/segments/1623488507640.82/warc/CC-MAIN-20210622033023-20210622063023-00207.warc.gz", "language_score": 0.9381288886070251, "token_count": 395, "dump": "CC-MAIN-2021-25", "global_id": "webtext-fineweb__CC-MAIN-2021-25__0__86064368", "lang": "en", "text": "Assessments of water repellency of soils are commonly made on air-dried or oven-dried samples, without considering the soil water content. The objectives of this study were to examine the spatial and temporal variability of soil water content, actual water repellency over short distances, and the variations in critical soil water contents. Between 22 April and 23 November 1999, numerous samples were collected from a grass-covered dune sand (typic Psammaquent), at six depths, eight times in transects and two times in soil blocks. The water drop penetration time (WDPT) test was used to measure the actual water repellency of the field-moist samples and the potential water repellency after drying the samples at 25, 65, and 105 °C. Highly spatial and temporal variability in water content and persistence of actual water repellency was found between the samples from all soil depths. At each depth we established an upper water content, below which samples were water repellent and a lower water content, above which samples were wettable. This water content range, called the transition zone, was different for each depth, and, for example, assessed at 0 to 2.5 cm depth between soil water contents of 18 and 23% (vol./vol.), and at 16.5 to 19 cm depth between 2 and 5% (vol./vol.). The potential water repellency of samples dried at 25 and 65 °C was on some days less severe than the actual repellency of field-moist samples on other days, thus underestimating the maximal persistence of water repellency that can occur in the field. Drying of the samples at 105 °C significantly increased the potential water repellency.\n|Journal||Soil Science Society of America Journal|\n|Publication status||Published - 2001|\n- soil water\n- water repellent soils\n- sandy soils", "domain": "chemistry", "round": 3} +{"url": "http://www.hanguojifang.com/product/573.html", "date": "2021-10-22T03:24:35Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-43/segments/1634323585450.39/warc/CC-MAIN-20211022021705-20211022051705-00445.warc.gz", "language_score": 0.8870985507965088, "token_count": 284, "dump": "CC-MAIN-2021-43", "global_id": "webtext-fineweb__CC-MAIN-2021-43__0__165914233", "lang": "en", "text": "Tel：086-512-58548238 / 58548236\nAdd: Xuetian Rd., Jingang Town, Zhangjiagang City, Jiangsu Province\nStretch wrap film is a kind of packaging method which is used to stretch the goods under the normal temperature and stretch the film by mechanical drawing or manual. It is a form of packaging which is very popular in the world. It's good tensile properties, tear resistance, penetration resistance, high transparency, good high shrinkage and self adhesive, packing closely, not loose etc..\nIt can be widely used in chemical raw materials, chemical fertilizers, food, mechanical and electrical products, textile products and other single or pallet packing and other bundled packaging.\n1. tensile packaging saves raw materials than shrinkage packing, and does not need heat shrinkable packer to save energy.\n2., high strength, large elastic pulling force, and can be wrapped tightly for any geometric shape commodity, and it can avoid damage caused by bundling. It has good effect of preventing looseness, rain and dustproof.\n3. can make use of high performance resin and excipients, and can meet the needs of different users in the maximum range.\n4. can make a single sticky product, reduce the noise emitted during the winding process, and reduce the dust and sand in the process of transportation and storage.", "domain": "chemistry", "round": 3} +{"url": "https://www.fujipress.jp/ijat/au/ijate000900060612/", "date": "2023-02-05T20:10:24Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-06/segments/1674764500288.69/warc/CC-MAIN-20230205193202-20230205223202-00689.warc.gz", "language_score": 0.6714267134666443, "token_count": 2638, "dump": "CC-MAIN-2023-06", "global_id": "webtext-fineweb__CC-MAIN-2023-06__0__183127324", "lang": "en", "text": "Fabrication Process of Antimony Telluride and Bismuth Telluride Micro Thermoelectric Generator\nMizue Mizoshiri*, Masashi Mikami**, and Kimihiro Ozaki**\n*Graduate School of Engineering, Nagoya University\nFuro-cho, Chikusa-ku, Nagoya, Aichi 464-8603, Japan\n**National Institute of Advanced Industrial Science and Technology\n2266-98 Anagahora, Moriyama-ku, Nagoya, Aichi 463-8560, Japan\nThis paper describes the process of fabricating micro thermoelectric generators (μ-TEGs) based on antimony telluride (Sb-Te) and bismuth telluride (Bi-Te). These materials have excellent thermoelectric (TE) conversion properties. The deposition and patterning processes for thermoelectric films are key techniques in the fabrication of μ-TEGs. However, it is difficult to form TE micropatterns using conventional semiconductor technologies because Sb-Te and Bi-Te are brittle and difficult to etch. Therefore, a semiconductor fabrication process is developed for TE film patterning. Here, various processes for depositing Sb-Te and Bi-Te TE films are described. Then, the combinations of the deposition and patterning techniques are reviewed. Finally, the generation properties of the μ-TEGs are summarized.\n- M. Kishi, H. Nemoto, T. Hamao, M. Yamamoto, S. Sudou, M. Mandai, and S. Yamamoto, “Micro thermoelectric modules and their application to wristwatches as an energy source,” Eighteenth International Conference on Thermoelectrics Proceedings, ICT’99, pp. 301-307, 1999.\n- M. Nishibori, W. Shin, K. Tajima, L. F. Houlet, N. Izu, I. Matsubara, and N. Murayama, “Catalyst combustors with B-Doped SiGe/Au thermopile for micro-power-generation,” Jpn. J. Appl. Phys., Vol.45, pp. L1130-L1132, 2006.\n- J. Q. Guo, H. Y. Geng, T. Ochi, S. Suzuki, M. Kikuchi, Y. Yamaguchi, and S. Ito, “Development of Skutterudite Thermoelectric Materials and Modules,” J. Electron. Mater., Vol.41, pp. 1036-1042, 2012.\n- M. Mikami, K. Kobayashi, T. Kawada, K. Kubo, and N. Uchiyama, “Development and Evaluation of High-Strength Fe2VAl Thermoelectric Module,” Jpn. J. Apl. Phys., Vol.47, pp. 1512-1516, 2008.\n- J. Xie, C. Lee, M.-F. Wang, Y. Liu, and H. Feng, “Characterization of heavily doped polysilicon films for CMOS-MEMS thermoelectric power generators,” J. Micromech. Microeng., Vol.19, pp. 125029-1-125029-8, 2009.\n- S. M. Yang, T. Lee, and M. Cong, “Design and verification of a thermoelectric energy harvester with stacked polysilicon thermocouples by CMOS process,” Sens. And Actuators, A157, pp. 258-266, 2010.\n- L. M. Goncalves, C. Couto, P. Alpuim, A. G. Vöolklein, and J. H. Correia, “Optimization of thermoelectric properties on Bi2Te3 thin films deposited by thermal co-evaporation,” Thin Solid Films, Vol.518, pp. 2816-2821, 2010.\n- H. Zou, D. M. Rowe, and G. Min, “Preparation and characterization of p-type Sb2Te3 and n-type Bi2Te3 thin films grown by coevaporation,” J. Vac. Sci. Technol. A, Vol.19, pp. 899-903.\n- L. W. da Silva, M. kaviany, and C. Uher, “Thermoelectric performance of films in the bismuth-tellurium and antimony-tellurium systems,” J. Appl. Phys., Vol.97, pp. 114903, 2005.\n- D.-H. Kim, S.-H. Lee, J.-K. Kim, and G.-H. Lee, “Structure and electrical transport properties of bismuth thin films prepared by RF magnetron sputtering,” Appl. Surf. Sci., Vol.252, pp. 3525-3531, 2006.\n- D.-H. Kim, E. Byon, G.-H. Lee, and S. Cho, “Effect of deposition temperature on the structural and thermoelectric properties of bismuth telluride thin films grown by co-sputtering,” Thin Solid Films, Vol.510, pp. 148-153, 2006.\n- H. Huang, W. Luan, and S. Tu, “Influence of annealing on thermoelectric properties of bismuth telluride films grown via radio frequency magnetron sputtering,” Thin Solid Films, Vol.517, pp. 3731-3734, 2009.\n- M. Mizoshiri, M. Mikami, K. Ozaki, and K. Kobayashi, “Thin-Film Thermoelectric Modules for Power Generation Using Focused Solar Light,” J. Electron. Mater., Vol.41, pp. 1713-1719, 2012.\n- D. Bourgault, C. G. Garampon, N. Caillault, L. Carbone, and J. A. Aymami, “Thermoelectric properties of n-type Bi2Te2.7Se0.3 and p-type Bi0.5Sb1.5Te3 thin films deposited by direct current magnetron sputtering,” Thin Solid Films, Vol.516, pp. 8579-8583, 2008.\n- M. Mizoshiri, M. Mikami, and K. Ozaki, “p-Type Sb2Te3 and n-Tyep Bi2Te3 Films for Thermoelectric Modules Deposited by Thermally Assisted Sputtering Method,” Jpn. J. Appl. Phys., Vol.52, pp. 06GL07-1-06GL07-6, 2013.\n- K. Park, F. Xiao, B. Y. Yoo, Y. Rheen, and N. V. Myung, “Electrochemical deposition of thermoelectric SbxTey thin films and nanowires,” J. Alloys Compd., Vol.485, pp. 362-366, 2009.\n- Y. Miyazaki and T. Kajitani, “Preparation of Bi2Te3 films by electrodeposition,” J. Cryst. Growth, Vol.229, pp. 542-546.\n- M. Takashiri, S. Tanaka, M. Takiishi, M. Kihara, K. Miyazaki, and H. Tsukamoto, “Preparation and characterization of Bi0.4Te3.0Sb1.6 nanoparticles and their thin films,” J. Alloys Compd., Vol.462, pp. 351-355, 2008.\n- K. Kato, H. Hagino, and K. Miyazaki, “Fabrication of Bismuth Telluride Thermoelectric Films Containing Conductive Polymers Using a Printing Method,” J. Electron. Mater., Vol.42, pp. 1313-1318, 2013.\n- D. Madan, A. Chen, P. K. Wright, and W. Evans, “Dispenser printed composite thermoelectric thick films for thermoelectric generator applications,” J. Appl. Phys., Vol.109, pp. 034904-1-034904-6, 2011.\n- B. Huang, C. Lawrence, A. Gross, G.-S. Hwang, N. Ghofouri, S.-W. Lee, H. Kim, C.-P. Li, C. Uher, K. Najafi, and M. Kaviany, “Low-temperature characteirzation and micropatterning of coevaporated Bi2Te3 and Sb2Te3 films,” J. Appl. Phys., Vol.104, pp. 113710-1-113710-8, 2008.\n- G. J. Snyder, J. R. Lim, C.-K. Huang, and J.-P. Fleurial, “Thermoelectric microdevice fabricated by a MEMS-like electrochemical process,” Nature Mater., Vol.2, pp. 528-531, 2003.\n- L. M. Goncalves, J. G. Rocha, C. Couto, P. Alpuim, G. Min, D. M. Rowe, and J. H. Correia, “Fabrication of flexible thermoelectric microcoolers using planar thin-film technologies,” J. Micromech. Microeng., Vol.17, pp. S168-S173, 2007.\n- M. Mizoshiri, M. Mikami, and K. Ozaki, “Thermal-Photovoltaic Hybrid Solar Generator Using Thin-Film Thermoelectric Modules,” Jpn. J. Appl. Phys., Vol.51, pp. 06FL07-1-06FL07-5, 2012.\n- M. Mizoshiri, M. Mikami, and K. Ozaki, “The effect of Cr buffer layer thickness on voltage generatioin of thin-film thermoelectric modules,” Vol.23, pp. 115016-1-115016-9, 2013.\n- M. Mizoshiri, M. Mikami, K. Ozaki, M. Shikida, and S. Hata, “Lift-off patterning of thermoelectric thick films deposited by a thermally assisted sputtering method,” Appl. Phys. Express, Vol.7, pp. 057101-1-057101-4.\n- L. M. Goncalves, C. Couto, P. Alpuim, and J. H. Correia, “Thermoelectric micro converters for cooliing and energy-scavenging systems,” J. Micromech. Microeng., Vol.18, pp. 064008-1-064008-5, 2008.\n- J. P. Carmo, J. F. Ribeiro, M. F. Silva, L. M. Goncalves, and J. H. Correia, “Thermoelectric generator and solid-state battery for stand-alone microsystems,” J. Micromech. Microeng., Vol.20, pp. 085033-1-, 2010.\nThis article is published under a Creative Commons Attribution-NoDerivatives 4.0 Internationa License.", "domain": "chemistry", "round": 3} +{"url": "https://fitofert.com/en/nutrition-of-vegetables-program/", "date": "2024-02-28T16:32:08Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707947474737.17/warc/CC-MAIN-20240228143955-20240228173955-00138.warc.gz", "language_score": 0.942351758480072, "token_count": 332, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__159988459", "lang": "en", "text": "During development and growth, every vegetable plant has certain needs for macro (N,P,K), secondary (Ca, Mg, S) and micro (Fe, B, Cu, Mn) nutrients depending on the stage of development. These quantities cannot be provided during regular soil fertilization but must be added during vegetation through fertigation and foliar nutrition.\nFitoFert fertilizers are in full accordance with different phenophases of vegetable development. Crystal water soluble formulations are primarily used for fertigation, but can be also applied as foliar nutrition in combination with micro and secondary nutrient fertilizers. We give our recommendations for growing different vegetable crop, as follows.\nProduction of vegetable seedlings – for most vegetable plants time needed to produce seedlings is from 4-8 weeks, during which period the plant has low needs for nutrients, and gets everything necessary for regular development, after sprouting until forming of the second true leaf, from nutrient substrates designed for sowing. For sowing, we recommend Kekkila professional supstarate specialized for sowing, granulations of 0-5 mm with 50% black and 50% of white peat, or granulations of 0-7 mm, both of them pH regulated and with amount of nutrients that is coordinated with seedling’s needs for nutrients in initial stages of development. Three weeks after sowing most of vegetable plants should be replanted into one of the Kekkila professional substrates such as TSM 1W, DSM 2W i OPM 015W. This supstrates provides the necessary amounts of essential nutrients at a given stage of development.", "domain": "chemistry", "round": 3} +{"url": "http://climeto.com/2023/01/13/an-overview-of-how-carbon-sequestration-works/", "date": "2023-12-02T20:48:34Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100452.79/warc/CC-MAIN-20231202203800-20231202233800-00437.warc.gz", "language_score": 0.9184257388114929, "token_count": 657, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__289035055", "lang": "en", "text": "Understand the fundamentals of carbon sequestration with this comprehensive overview! Learn about different technologies, mechanisms, and methods for carbon capture.\nCarbon sequestration is the process of capturing carbon dioxide from the atmosphere and storing it in safe, secure locations. Through this process, we can reduce greenhouse gases like CO2 which are responsible for global climate change. Learn more about how the technology works, its advantages, and potential obstacles to implementation.\nWhat is Carbon Sequestration?\nIt is a process in which CO2 is captured from the atmosphere and stored in various safe locations. It could refer to both natural mechanisms and human-made methods of capturing carbon, such as ocean sediment deposits, soil, plants, buildings and technology. By capturing CO2 emissions from the atmosphere, we can help reduce the number of greenhouse gases that contribute to global climate change.\nCarbon sequestration is a potentially powerful tool for combating climate change. This process helps remove excess carbon from the atmosphere, reducing the concentration of greenhouse gases — primarily CO2, methane and nitrous oxide — in our environment. By reducing the amount of these greenhouse gases present in the atmosphere, we can help cool down Earth and mitigate the various effects of global warming. Especially as human activities are responsible for most of the increase in atmospheric concentrations of CO2, carbon sequestration offers us a way to reduce levels of greenhouse gas pollution without fundamentally changing our lifestyle.\nThe Different Types of Carbon Sequestration:\nCarbon sequestration can be categorized into two types – terrestrial and oceanic. Terrestrial carbon sequestration is the process of storing CO2 in terrestrial ecosystems such as forests, soils, crops, and other land sources. Oceanic or marine carbon sequestration involves capturing CO2 from the atmosphere and storing it beneath the surface of oceans or other bodies of water. There are also alternative solutions such as Enhanced Weathering (EW), Enhanced Oil Recovery (EOR) and Direct Air Capture (DAC).\nImplementing Strategies to Capture and Store Carbon:\nOnce a carbon capture and storage system has been developed, it is important to determine the best strategy for implementing it. Several important elements must be taken into consideration, such as safety regulations, cost-effectiveness, capture and transport technologies, monitoring systems, potential leakage paths, closure planning and public perception. When these are all weighed together, an efficient and cost-effective approach can be chosen to implement carbon capture and storage.\nTesting and Monitoring the Results:\nMonitoring and verification processes must be put in place to ensure that the effectiveness of the sequestration process remains constant over time. These tests can include measuring the CO2 levels in groundwater and surface water, surveying vegetation, checking soil and sediment samples for carbon content, detecting environmental changes due to accelerated rock weathering, and using airborne or satellite imaging to monitor changes in land cover.\nBenefits and Challenges of Using Carbon Sequestration as a Climate Solution:\nIt can be beneficial in reducing greenhouse gas emissions, but there are a number of challenges to consider as well. These include cost, the potential for carbon leakage, difficulty in monitoring long-term effects, and potential unintended environmental consequences. Additionally, large-scale implementation of carbon sequestration methods may require significant investments in infrastructure and technology.", "domain": "chemistry", "round": 3} +{"url": "http://www.oxygennitrogengenerator.com/sale-12496937-medical-psa-oxygen-gas-plant-for-aquaculture-factory-pressure-swing-adsorption.html", "date": "2022-06-28T22:10:35Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-27/segments/1656103617931.31/warc/CC-MAIN-20220628203615-20220628233615-00134.warc.gz", "language_score": 0.688634991645813, "token_count": 758, "dump": "CC-MAIN-2022-27", "global_id": "webtext-fineweb__CC-MAIN-2022-27__0__97771358", "lang": "en", "text": "Payment & Shipping Terms:\n|Dimension(l*w*h):||Actual Size)||Oxygen Purity:||90%+-3%|\n|Warranty:||1 Year||After-sales Service Provided:||Video Technical Support|\npressure swing adsorption oxygen generator,\npsa oxygen plant\nHospital Medical Psa Oxygen Gas Plant For Aquaculture Factory Pressure Swing Adsorption\n1. Technical parameters\n1). Oxygen yield: 3~400Nm3/h\n2). Oxygen purity: 90%~93%\n3). Oxygen pressure: 0.1~0.4MPa\n4). Dew point of oxygen: ≤ -45℃ (Special requirements can be below -60 ℃)\n2. Working Principle\nOxygen Usage and New Condition high quality oxygen gas generator\noxygen gas generator system, an on site oxygen generation system, is especially designed for hospital and indutrial oxygen supply. The system will end your expensive reliance on traditional bulk liquid oxygen or cylinders oxygen without compromise on safety and reliability.\noxygen gas generator system consists of air compressor, dryer, air filters, PSA oxygen generator, oxygen monitoring system and oxygen back up system.\n3. Process Flow Brief Description\n4. Technical characteristics of PSA oxygen generator\n5. Main characteristic\n1). Use the man-machine interface,intelligentize control,operation easy,supply the qualified oxygen in short time.\n2). High efficiency fill in ZMS,tighter,solid,longer usage life\n3). Use Siemens , OMRON PLC control and Germany BURKERT pneumatic valve to change system automatically,working stable.\n4). Pressure,purity,flow can adjustable,to satisfied customers’ requirements.\n5). Whole sealing design,Structural tension ,beautiful appearance,save floor area\n1). Are you a manufacturer or a trade Company?\nWe are professional OEM High efficient Skid mounted oxygen generator plant factory, founded in 1997.\n2). What's the order process of oxygen gas generator?\na. Inquiry---tell us all clear requirements.\nb. Quotation---official quotation form with all clear specifications.\nc. Printing file--- PDF, Ai, CDR, PSD, the picture resolution must be at least 300 dpi.\nd. Contract confirmation---provide correct contract details.\ne. Payment terms--- T/T 30% in advanced, then balanced before shipment.\nf. Production---mass production\ng. Shipping--- by sea, air or express. Detailed package pictures will be available.\nh. Installation and commissioning\n3). What terms of payment you use?\nT/T, L/C, cash, etc.\n4). How to get a quotation of oxygen gas generator ?\nWhen you inquire to us, pls also provide with us the following technical information:\n1) O2 flow rate: _____Nm3/h( or How many cylinders do you want to fill per day(24 hours)\n2) O2 purity: _____%\n3) O2 discharge pressure: _____Bar\n4) Voltages and Frequency : ______V/PH/HZ\nContact Person: Sunny", "domain": "chemistry", "round": 3} +{"url": "http://www.hopkinsmedicine.org/profiles/results/directory/profile/0423453/gustavo-maegawa?CLEARPAGECACHE=false&spec_disease=Genetics&directRef=%2Fdoctors%2Fresults%2Fdirectory%2Fprofile%2F0423453%2Fgustavo%2Dmaegawa", "date": "2015-10-07T18:38:42Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2015-40/segments/1443737875203.46/warc/CC-MAIN-20151001221755-00047-ip-10-137-6-227.ec2.internal.warc.gz", "language_score": 0.7850629091262817, "token_count": 1010, "dump": "CC-MAIN-2015-40", "global_id": "webtext-fineweb__CC-MAIN-2015-40__0__121727944", "lang": "en", "text": "The research in Dr. Maegawa’s lab is focused on developing new therapies of lysosomal storage diseases (LSDs). These inherited metabolic conditions are caused by defects in a wide spectrum of lysosomal and a few non-lysosomal proteins, resulting in the accumulation of undigested or partially digested intermediates. Small molecule therapeutics are an attractive approach to treat LSDs. Enzyme-enhancement agents, including pharmacological chaperones (PC), are small molecules that are able to assist a mutant misfolded protein to achieve a native-like conformation in the endoplasmic reticulum (ER), allowing it to escape the ER-associated degradation (ERAD) pathway and reach the lysosome.\nIn Dr. Maegawa’s early studies screening an FDA-approved drug library, pyrimethamine, a drug used to treat malaria and toxoplasmosis, was identified as a PC for hexosaminidase A, which is deficient in GM2 gangliosidosis (Tay-Sachs and Sandhoff diseases) (Maegawa et al. 2007). In another study, ambroxol, a drug used for chronic bronchitis, was found to enhance and stabilize mutant forms of glucocebrosidase, an enzyme deficient in Gaucher disease (Maegawa et. al. 2009).\nCurrently, the lab is developing high throughput screening (HTS) assays to identify specific chemical compounds to assist folding of mutant lysosomal proteins.\nDr. Maegawa’s lab is focused on developing new therapies for lysosomal storage diseases (LSDs) based on the understanding of molecular mechanisms of the pathogenesis of these diseases.\nOngoing research projects are related to:\n- Identifying small molecule therapies by HTS assays using LSD patient cells\n- Investigating pathogenic cascades in LSDs as potential therapeutic targets\n- LSD clinical studies\nA Phase 1/2, Open Label, Dose Ranging Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Exploratory Efficacy Parameters of PRX-102 Administered by Intravenous Infusion Every 2 Weeks for 12 Weeks to Adult Fabry Patients\nKano SI, Yuan M, Cardarelli RA, Maegawa G, Horiuchi Y, Higurashi N, Gaval-Cruz M, Wilson AM, Tristan C, Kondo MA, Chen Y, Koga M, Obie C, Ishizuka K, Seshadri S, Srivastava R, Kato TA, Sedlak TW, Lee Y, Rapoport JL, Hirose S, Okano H, Valle D, O'Donnell P, Sawa A, Kai M. \"Clinical utility of neuronal cells directly converted from fibroblasts of patients for neuropsychiatric disorders: studies of lysosomal storage diseases and channelopathy.\" Curr Mol Med. 2015 Mar 2. [Epub ahead of print\nTeixeira CA, Miranda CO, Sousa VF, Santos TE, Malheiro AR, Solomon M, Maegawa GH, Brites P, Sousa MM. \"Early axonal loss accompanied by impaired endocytosis, abnormal axonal transport, and decreased microtubule stability occur in the model of Krabbe's disease.\" Neurobiol Dis. 2014 Jun;66:92-103. doi: 10.1016/j.nbd.2014.02.012. Epub 2014 Mar 6.\nAlqahtani E, Huisman TA, Boltshauser E, Scheer I, Güngör T, Tekes A, Maegawa GH, Poretti A. \"Mucopolysaccharidoses type I and II: new neuroimaging findings in the cerebellum.\" Eur J Paediatr Neurol. 2014 Mar;18(2):211-7. doi: 10.1016/j.ejpn.2013.11.014. Epub 2013 Dec 31.\nPastores GM, Maegawa GH. \"Clinical neurogenetics: neuropathic lysosomal storage disorders.\" Neurol Clin. 2013 Nov;31(4):1051-71. doi: 10.1016/j.ncl.2013.04.007. Review.\nRibbens JJ, Moser AB, Hubbard WC, Bongarzone ER, Maegawa GH. \"Characterization and application of a disease-cell model for a neurodegenerative lysosomal disease.\" Mol Genet Metab. 2014 Feb;111(2):172-83. doi: 10.1016/j.ymgme.2013.09.011. Epub 2013 Sep 21.", "domain": "chemistry", "round": 3} +{"url": "http://biomedigs.org/2018/08/12/in-this-research-we-establish-that-cholesterol-and-sphingolipid-connected-with/", "date": "2023-12-09T01:04:33Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100781.60/warc/CC-MAIN-20231209004202-20231209034202-00585.warc.gz", "language_score": 0.9490369558334351, "token_count": 1277, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__111922947", "lang": "en", "text": "In this research, we establish that cholesterol and sphingolipid connected with hepatitis C virus (HCV) contaminants are essential for virion maturation and infectivity. protein partitioned into mobile detergent-resistant, lipid-raft-like membranes. Combined with observation that inhibitors from the T 614 sphingolipid biosynthetic pathway stop virion production, however, not RNA deposition, within a JFH-1 isolate, our results claim that alteration from the lipid structure of HCV contaminants might be a good approach in the look of anti-HCV therapy. Hepatitis C trojan (HCV) is regarded as a major reason behind chronic liver organ disease, including persistent hepatitis, hepatic steatosis, cirrhosis, and hepatocellular carcinoma. It currently affects around 200 million people world-wide (26). HCV can be an enveloped positive-strand RNA trojan owned by the genus from the family members sphingomyelinase (SMase) was extracted from Higeta Shoyu (Tokyo, Japan). (1for 3 h to create a pellet, that was resuspended in 0.5 ml from the medium. To be able to replenish cholesterol, the moderate of HCVcc treated with 5 mg/ml T 614 B-CD was changed with DMEM filled with several concentrations of exogenous cholesterol (Sigma) and incubated for 1 h, accompanied by centrifugation to create a pellet. To be able to perform HCVcc illness assays, Huh-7 cells had been contaminated with HCVcc, with or without the procedure referred to above, for 1 h at 37C and washed as referred to above. Viral primary protein amounts in the cells and in the supernatant had been quantified 72 h later on using an HCV primary enzyme-linked immunosorbent assay (Ortho-Clinical Diagnostics, Tokyo, Japan). SMase treatment. HCVcc was treated with SMase at different concentrations in DMEM for 1 h at 37C and was after that centrifuged at 100,000 for 3 h to create a pellet, that was resuspended in 0.5 ml of medium for chlamydia assays. HCVcc binding and internalization assays. To monitor binding, cells cultivated inside a 6-well dish had been preincubated for 1 h at 4C, and B-CD- or SMase-treated HCVcc was destined to the cells for 1 h at 4C. Like a measure of disease internalization, following a disease binding treatment, the cells had been warmed to 37C T 614 and taken care of for 2 h, and these were treated with 0.25% trypsin T 614 for 10 min at 37C. Huh7-25, a Compact disc81-bad Huh-7 subclone (3), was utilized to make sure removal of surface-bound disease by trypsin treatment. For both binding and internalization assays, the ensuing cells, as referred to above, had been cleaned with ice-cold phosphate-buffered saline, accompanied by lysis with TRIzol reagent (Invitrogen). Cell-associated disease was quantified by calculating the quantity of HCV RNA in the cell lysate from the real-time invert transcription-PCR technique (2, 34). Cells had been treated with heparinase as previously referred to (33). HCV replication assay in HCVcc-infected or replicon cells. HCV subgenomic replicon cells or cells contaminated with HCVcc had been treated with different concentrations of inhibitors for 72 h. Total RNA was isolated from replicon cells using TRIzol reagent (Invitrogen), accompanied by quantification of HCV RNA by real-time invert transcription-PCR as previously referred to (2, 34). Degrees of primary proteins in the tradition supernatants of HCVcc-infected cells had been tested as referred to above. Recognition of cholesterol content material of HCVcc. For [3H]cholesterol labeling of infections, HCVcc-infected or uninfected cells had been incubated with 50 mCi of [1,2-3H]cholesterol in DMEM for 24 h. Tradition supernatants from the cells had been incubated in the existence or lack of B-CD at 5 mg/ml for 1 h at 37C, accompanied by ultracentrifugation on the 60% sucrose cushioning. The virus-containing fractions and related fractions from an uninfected tradition had been lysed in T 614 the buffer comprising 1% Triton X-100 (TX-100), and radioactivity was quantified by scintillation keeping track of. Radioactivities (in matters each and every minute) of HCVcc examples had been dependant on subtracting the radioactivity of uninfected cells from that of HCVcc-infected cells. Metabolic labeling evaluation of sphingolipid content material. After 2 h Rabbit Polyclonal to CATL1 (H chain, Cleaved-Thr288) of incubation with [14C]serine (0.5 mCi/ml) in Opti-MEM (Invitrogen), the cells had been lysed with 0.1% sodium dodecyl sulfate, and total lipid was extracted with chloroform-methanol (1:2, vol/vol). The components had been noticed onto silica gel 60 plates (Merck, Darmstadt, Germany) and chromatographed with methyl acetate-1-propanol-chloroform-methanol-0.25% KCl (25:25:25:10:9, vol/vol). Radioactive places had been quantitatively recognized by BAS 2000 (Fuji Film, Japan). Membrane flotation assay. The membrane flotation assay was performed as previously referred to (46). RESULTS Essential part of virion-associated cholesterol. A job of virion-associated cholesterol in infectivity continues to be demonstrated for a number of.", "domain": "chemistry", "round": 3} +{"url": "https://www.dancoindustry.com/industry/aerospace", "date": "2023-11-29T02:31:59Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100047.66/warc/CC-MAIN-20231129010302-20231129040302-00376.warc.gz", "language_score": 0.8907086253166199, "token_count": 256, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__242475208", "lang": "en", "text": "FLUID SEALING TECHNOLOGIES\nfor DEMANDING APPLICATIONS\nYOUR CENTRAL & EASTERN EUROPEAN PARTNER\nIndustry & Applications\nShort lead-times and production capabilities fit well with the requirements of maintenance, repair and overhaul operations. We have efficient make-to-order capabilities where limitations on cure dates (shelf life) prevent speculative stock holding of spares. A range of materials are available which conform to the test requirements used in a wide range of aircraft and support systems. In addition to the more traditional areas of sealing such as in electrical and fuel systems, our materials with extreme temperature capabilities such as phenyl silicones and perfluoroelastomers are being specified for demanding applications such as jet engines, laser infra-red counter measures and high pressure gas generators. Elastomers typically used in this industry include high FKMs, low temperature FKM, ultra-low compression set FKM, low temperature fluorosilicones, nitriles (NBR), special EPDMs and ultra-high temperature FFKMs. Typical system applications include hydraulics, lubrication systems, fuel systems and pneumatics.\nAdditionally, we supply high performance rubberised fabrics to protect and insulate.", "domain": "chemistry", "round": 3} +{"url": "https://search.spe.org/i2kweb/SPE/doc/onepetro:4F0320D7/", "date": "2019-10-17T18:32:11Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-43/segments/1570986675598.53/warc/CC-MAIN-20191017172920-20191017200420-00185.warc.gz", "language_score": 0.9087892174720764, "token_count": 292, "dump": "CC-MAIN-2019-43", "global_id": "webtext-fineweb__CC-MAIN-2019-43__0__102652495", "lang": "en", "text": "Presence of H2S detected in producing wells of North Kuwait sweet waterflooded reservoirs over the last 18 years, gave indications of biogenic souring. In response to this, the Kuwait Oil Company engaged in detailed souring potential assessments of selected reservoirs such as the Raudhatain Mauddud (RAMA), to predict the further generation of H2S and define the required souring mitigation strategy to ensure safe production over the remaining field life.\nThe souring simulation modelling was conducted on the RAMA subsurface model with support from Shell, using a state of the art souring prediction program. The initial phase of the study consisted in the history match simulation to define the most likely souring mechanism in the field. The forecast considered various scenarios with a range of sensitivities on carbon nutrient and sulphate levels, both in formation and injected water in the field.\nThe history match simulation results showed a good correlation with most of the producers with available H2S data. The Forecast simulation over the next 15-year period predicts a moderate souring severity for this reservoir, based on the maximum H2S mass flow rate of 90 kg/d and H2S in gas maximum concentration of 85 ppmv at the field level.\nThis work provides the petroleum Industry further insights into the souring behavior when effluent water is injected in addition to seawater, particularly the effects of additional carbon nutrients fed into the reservoir.", "domain": "chemistry", "round": 3} +{"url": "http://dkhomeworktnlf.bluewindow.me/carbon-cycle-essay.html", "date": "2018-05-24T21:08:06Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-22/segments/1526794866870.92/warc/CC-MAIN-20180524205512-20180524225512-00510.warc.gz", "language_score": 0.9349494576454163, "token_count": 595, "dump": "CC-MAIN-2018-22", "global_id": "webtext-fineweb__CC-MAIN-2018-22__0__176102315", "lang": "en", "text": "Access to over 100,000 complete essays and term papers the nitrogen cycle is a complex one some examples include carbon cycle, the nitrogen cycle. Read this essay on carbon cycle come browse our large digital warehouse of free sample essays get the knowledge you need in order to pass your classes and more. Extracts from this document introduction human effect on the carbon cycle an increase in greenhouse gases in our atmosphere, majority of it being carbon dioxide. Carbon is the basis for all life on earth this essay will explain the role of carbon dioxide in various parts of the carbon cycle this essay will examine two main. Carbon cycle essay - instead of worrying about research paper writing find the needed help here cooperate with our scholars to receive the top-notch review meeting. Advertisements: after reading this essay you will learn about the carbon cycle balance is essential to the earth chemical cycles keep the amount of elements on the.\nCarbon cycle essay analitical descriptive narrative carbon cycle essay essay carbon cycle mercury research paper write my carbon cycle essay pay us to write your. Carbon essays - see the list of sample papers for free - bla bla writing carbon essays carbon cycle essay, carbon essay, essay on carbon. The carbon cycle carbon is found in the atmosphere, and in the air that is breathed by all organisms one example of an organism using 〖co〗_2 is a fern plant a fern leaf opens its stomata, which are cell wide holes used by the plant to exchange gases by deflating its guard cells that surround the holes. Carbon cycle essay - receive a 100% authentic, non-plagiarized thesis you could only dream about in our academic writing service commit your essay to us and we will.\nSince it is a cycle, it can begin anywhere let us start with the atmosphere the forms of carbon in the atmosphere are methane and carbon dioxide. This essay has been submitted by a student this is not an example of the work written by our professional essay writers the carbon cycle can be defined as the continuous biological process through which the carbon is exchanged between the.\nThe carbon cycle is the process by which carbon moves from the atmosphere into the earth and its organisms and then back again gain a deeper. Carbon essays: over 180,000 carbon essays, carbon term papers, carbon research paper, book reports 184 990 essays, term and.\nEssay on carbon cycle although there is not much i can partake in, i managed to make my weekly grilling a family affair and also plan my cheat meals out so that i get. Carbon cycle carbon in air and in water is absorbed by plants and becomes carbon compounds in their tissues when they photosynthesise the carbon, from these. Carbon cycle lab essay carbon can be transferred to soil due to gases by human | |activity | |using the data generated by the simulation, determine the mathematical relationship between the percentage increase in fossil fuel | |consumption and the increase in atmospheric carbon.", "domain": "chemistry", "round": 3} +{"url": "https://www.ars.usda.gov/research/publications/publication/?seqNo115=156904", "date": "2022-08-13T12:13:28Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571950.76/warc/CC-MAIN-20220813111851-20220813141851-00556.warc.gz", "language_score": 0.8878691792488098, "token_count": 614, "dump": "CC-MAIN-2022-33", "global_id": "webtext-fineweb__CC-MAIN-2022-33__0__203959596", "lang": "en", "text": "Submitted to: Biotechnology for Fuels and Chemicals Symposium Proceedings\nPublication Type: Abstract Only\nPublication Acceptance Date: 5/12/2004\nPublication Date: 5/12/2004\nCitation: Liu, S., Saha, B.C., Cotta, M.A. 2004. Cloning, expression, purification, and analysis of mannitol dehydrogenase of mtlD and mtlK genes from Lactobacillus plantarum and Lactobacillus brevis [abstract]. Biotechnology for Fuels and Chemicals. Paper No. 2-24.\nTechnical Abstract: The commercial production of mannitol involves high-pressure hydrogenation of fructose using a nickel catalyst, a fairly costly and inefficient process. Mannitol can be produced through fermentation processes by microorganisms. Currently, a few lactobacillus strains are being used to develop a mannitol production process. However, Lactobacillus sp. produce products in addition to mannitol during fermentation, and the production efficiency could be improved. An approach toward improving this process would be to genetically engineer lactobacillus strains to increase mannitol production efficiency. The mannitol dehydrogenase genes mtlD, encoding mannitol-1-phosphate 5-dehydrogenase (EC 22.214.171.124) from L. plantarum, and mtlK, encoding mannitol-2-dehydrogenase (EC 126.96.36.199) from L. brevis, were isolated and characterized. The mtlD and mtlK were cloned via PCR from genomic DNA using the GenBank sequence of L. plantarum (http://www.ncbi.nlm.nih.gov) and the partially assembled genomic DNA sequence of L. brevis (http://www.er.doe.gov). The clone for mtlD of L. plantarum contains 1375 bp genomic DNA sequence. This includes the full length open reading frame of 1158 nucleotides encoding mannitol-1-phosphate 5-dehydrogenase that consists of 385 amino acids with a predicted molecular mass of about 42 kDa. The clone for mtlK gene in L. brevis contains 1328 bp genomic DNA sequence and includes the full length open reading frame of 1002 nucleotides encoding mannitol-2-dehydrogenase that consists of 333 amino acids with a predicted molecular mass of about 36 kDa. The mtlD and mtlK genes were then moved into an expression vector and expressed in E. coli BL21 cells after IPTG induction. Both mannitol-1-phosphate 5-dehydrogenase and mannitol-2-dehydrogenase proteins were purified using Ni**2+ matrix column. Further characterization of these enzymes is in progress.", "domain": "chemistry", "round": 3} +{"url": "https://www.bio-techne.com/p/antibodies/phospho-tyrosine-biotinylated-antibody-179003_bam1676", "date": "2023-12-08T23:02:42Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100779.51/warc/CC-MAIN-20231208212357-20231209002357-00898.warc.gz", "language_score": 0.8041772842407227, "token_count": 510, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__249424671", "lang": "en", "text": "Key Product Details\nProduct Summary for Phospho-Tyrosine Biotinylated Antibody\nScientific Data Images for Phospho-Tyrosine Biotinylated Antibody\nDetection of Phospho-PDGF R beta by ELISA.Human Foreskin Fibroblasts were untreated or treated with 100 ng/mL Recombinant Human PDGF-AA (Catalog # 221-AA), Recombinant Human PDGF-AB (Catalog # 222-AB), or Recombinant Human PDGF-BB (Catalog # 222-BB) for 5 minutes at 37 °C in serum-free medium. Activation of PDGF R beta was assessed by ELISA using Human PDGF R beta Antibody (Catalog # MAB385) as the capture reagent and Phospho-Tyrosine Biotinylated Monoclonal Antibody (Catalog # BAM1676) as the detection reagent.\nDetection of Phospho-Tyrosine by Western Blot.Western blot shows lysates of A431 human epithelial carcinoma cell line untreated (-) or treated (+) with 50 µM pervanadate (PV) for 15 minutes. PVDF membrane was probed with 1 µg/mL of Mouse Anti-Phospho-Tyrosine Biotinylated Monoclonal Antibody (Catalog # BAM1676), followed by HRP-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # HAF007). Tyrosine-phosphorylated proteins were detected (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 10.\nApplications for Phospho-Tyrosine Biotinylated Antibody\nSample: Proteins containing phosphorylated tyrosine residues\nSample: Pervanadate-treated A431 human epithelial carcinoma cell line\nRead 3 publications using BAM1676 in the following applications:\nFormulation, Preparation and Storage\nStability & Storage\n- 12 months from date of receipt, -20 to -70 °C as supplied.\n- 1 month, 2 to 8 °C under sterile conditions after reconstitution.\n- 6 months, -20 to -70 °C under sterile conditions after reconstitution.\nProduct Specific Notices for Phospho-Tyrosine Biotinylated Antibody\nFor research use only", "domain": "chemistry", "round": 3} +{"url": "https://link.springer.com/chapter/10.1007/978-1-4684-7808-2_3", "date": "2018-08-20T07:27:41Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-34/segments/1534221215858.81/warc/CC-MAIN-20180820062343-20180820082343-00200.warc.gz", "language_score": 0.7523382306098938, "token_count": 604, "dump": "CC-MAIN-2018-34", "global_id": "webtext-fineweb__CC-MAIN-2018-34__0__87551685", "lang": "en", "text": "Carbohydrate Metabolism and Energy Production\nAn almost universal feature of endoparasitic organisms is their dependence upon anaerobic carbohydrate metabolism to obtain energy, regardless of the amount of environmental oxygen available. Accordingly, a great many parasites store polysaccharides which can be oxidised (though rarely to completion) to yield ATP. The most common polysaccharide reserve is glycogen, occurring in protozoans and helminths alike. Glycogen is composed exclusively of glucose molecules joined by α-1, 4 and α-1, 6 linkages, the ratio of 1, 4:1, 6 bonds ranging from 12:1 to 15:1.\nKeywordsCarbohydrate Metabolism Volatile Fatty Acid Malic Enzyme Echinococcus Granulosus Ascaris Lumbricoides\nUnable to display preview. Download preview PDF.\n- Atkinson, H. J. (1976) “The respiratory physiology of nematodes”, in The Organization of Nematodes, editor N. A. Croll, Academic Press, 243–272.Google Scholar\n- Barrett, J. (1976) “Bioenergetics in helminths”, in Biochemistry of Parasites and Host-Parasite Relations, editor H. Van den Bossche, North Holland, 67–80.Google Scholar\n- Coles, G. C. (1975) “Fluke biochemistry-Fasciola and Schistosoma.” Helminthological Abstracts (A), 44, 147–162.Google Scholar\n- Gutteridge, W. E. and Coombs, G. H. (1977) Biochemistry of Parasitic Protozoa, Macmillan.Google Scholar\n- Hill, G. C. (1970) “Characterization of the electron transport systems present during the life cycle of African trypanosomes”, in Biochemistry of Parasites and Host-Parasite Relations, editor H. Van den Bossche, North Holland, 31–50.Google Scholar\n- Lee and Atkinson (1976) Physiology of Nematodes,2nd edition, Macmillan Press.Google Scholar\n- Read, C. P. and Simmons, J. E. (1963) “Biochemistry and physiology of tapeworms.” Physiological Reviews, 43, 263–305.Google Scholar\n- Saz, H. J. (1969) “Carbohydrate and energy metabolism of nematodes and Acanthocephala.” Chemical Zoology, 3, 329–360.Google Scholar\n- Smith, M. H. (1969) “Do intestinal parasite require oxygen?” Nature, 223, 1129–1132. Von Brand, T. (1973) Biochemistry of Parasites, 2nd edition, Academic Press.Google Scholar", "domain": "chemistry", "round": 3} +{"url": "http://mingen.hk/parabutlerite.html", "date": "2021-06-25T06:56:34Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-25/segments/1623487622113.11/warc/CC-MAIN-20210625054501-20210625084501-00036.warc.gz", "language_score": 0.7807134985923767, "token_count": 370, "dump": "CC-MAIN-2021-25", "global_id": "webtext-fineweb__CC-MAIN-2021-25__0__21231814", "lang": "en", "text": "Hydrated sulphate containing hydroxyl, orthorhombic paramorph of butlerite, which is monoclinic. Butlerite is sometimes epitaxial on parabutlerite. Parabutlerite has been observed as pseudomorphs after copiapite.\nSpecific gravity: 2.55\nStreak: Light yellow\nColour: Pale orange to pale orange-brown; light yellow in transmitted light.\nSolubility: Insoluble in cold or hot water; soluble in dilute acids\nParabutlerite is an uncommon mineral in the oxidised zone of pyritic veins;\nit may be formed by alteration of copiapite. Associated minerals include\nmelanterite and fibroferrite\nAt Santa Elena Mine, Quebrada Alcaparrosa, Calingasta, Calingasta Department, San Juan Province, Argentina, parabutlerite occurs with butlerite, fibroferrite and other sulphates (Dana).\nThere are two co-type localities, the Alcaparrosa Mine, Cerritos Bayos, and the Chuquicamata Mine, Chuquicamata District, both at Calama, El Loa Province, Antofagasta, Chile. At Alcaparrosa parabutlerite occurs in a bed about 8 inches thick above copiapite. It results from the alteration of copiapite and in part is pseudomorphic after it. Parabutlerite also occurs with copiapite and jarosite at Quetena and Chuquicamata. All of the field evidence points to the conclusion that parabutlerite formed after copiapite (AM 23.669-760).\nBack to Minerals", "domain": "chemistry", "round": 3} +{"url": "https://www.astm.org/Standards/D1636.htm", "date": "2021-10-22T07:37:46Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-43/segments/1634323585460.87/warc/CC-MAIN-20211022052742-20211022082742-00223.warc.gz", "language_score": 0.8466781377792358, "token_count": 836, "dump": "CC-MAIN-2021-43", "global_id": "webtext-fineweb__CC-MAIN-2021-43__0__234905014", "lang": "en", "text": "| ||Format||Pages||Price|| |\n|3||$48.00||  ADD TO CART|\n|Hardcopy (shipping and handling)||3||$48.00||  ADD TO CART|\n|Standard + Redline PDF Bundle||6||$56.00||  ADD TO CART|\nThis specification provides for the identification of three types of allyl molding compounds, based on the general type of filler employed in their manufacture: Type I - High-strength materials, glass-fiber reinforced; Type II - General-purpose mineral filled; and Type III - General-purpose synthetic fiber filler. Types I and II may be subdivided into four classes according to resin composition and use as follows: Class A - Diallyl ortho-phthalate resin, nonflame-retardant; Class B - Diallyl ortho-phthalate resin, flame-retardant; Class C - Diallyl meta-phthalate resin nonflame-retardant; and Class D - Diallyl meta-phthalate resin, flame-retardant. Materials shall be compression molded, conditioned, and tested; and the individual grades shall conform to specified values of impact resistance, flexural strength, permittivity and dissipation factor, insulation resistance, flame resistance, and oxygen index.\nThis abstract is a brief summary of the referenced standard. It is informational only and not an official part of the standard; the full text of the standard itself must be referred to for its use and application. ASTM does not give any warranty express or implied or make any representation that the contents of this abstract are accurate, complete or up to date.\n1.1 This specification covers compression molding, thermosetting, allyl compounds as further defined in Section .\n1.2 The values stated in SI units are to be regarded as standard. No other units of measurement are included in this standard.\nNote 1: The properties included in this specification are those required to identify the molding compounds covered. There may be other requirements necessary to identify particular characteristics. These will be added to the specification as their inclusion becomes generally desirable and the necessary test data and methods become available.\nNote 2: There is no known ISO equivalent to this standard.\n1.3 This international standard was developed in accordance with internationally recognized principles on standardization established in the Decision on Principles for the Development of International Standards, Guides and Recommendations issued by the World Trade Organization Technical Barriers to Trade (TBT) Committee.\n2. Referenced Documents (purchase separately) The documents listed below are referenced within the subject standard but are not provided as part of the standard.\nD150 Test Methods for AC Loss Characteristics and Permittivity (Dielectric Constant) of Solid Electrical Insulation\nD229 Test Methods for Rigid Sheet and Plate Materials Used for Electrical Insulation\nD256 Test Methods for Determining the Izod Pendulum Impact Resistance of Plastics\nD257 Test Methods for DC Resistance or Conductance of Insulating Materials\nD618 Practice for Conditioning Plastics for Testing\nD790 Test Methods for Flexural Properties of Unreinforced and Reinforced Plastics and Electrical Insulating Materials\nD883 Terminology Relating to Plastics\nD2863 Test Method for Measuring the Minimum Oxygen Concentration to Support Candle-Like Combustion of Plastics (Oxygen Index)\nD3892 Practice for Packaging/Packing of Plastics\nD5224 Practice for Compression Molding Test Specimens of Thermosetting Molding Compounds\nICS Number Code 83.140.99 (Other rubber and plastic products)\nUNSPSC Code 13111032(Allyl)\n|Link to Active (This link will always route to the current Active version of the standard.)|\nASTM D1636-21, Standard Specification for Allyl Molding Compounds, ASTM International, West Conshohocken, PA, 2021, www.astm.orgBack to Top", "domain": "chemistry", "round": 3} +{"url": "https://scholarsmine.mst.edu/matsci_eng_facwork/2723/", "date": "2023-12-07T16:22:15Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100677.45/warc/CC-MAIN-20231207153748-20231207183748-00063.warc.gz", "language_score": 0.9064508676528931, "token_count": 454, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__288563359", "lang": "en", "text": "Characterization of Fusion Welded Ceramics in the SiC-ZrB₂-ZrC System\nVarious SiC-ZrB2-ZrC ceramics were joined by fusion welding to determine the maximum silicon carbide content that could be joined. Commercial powders were hot pressed, machined, and preheated to 1450 °C before joining with a tungsten inert gas welding torch at 160–200 A. Resulting welds were cross-sectioned and analyzed to determine which compositions were weldable and to characterize microstructural evolution in welded samples. As compositions approached the ternary eutectic, the welds had smaller SiC grains and exhibited better weldability. Penetration depth of welds was controlled by a combination of current input and welding speed. The ternary eutectic in the system was found at 36.9 ± 1.3 vol% SiC, 42.7 ± 1.5 vol% ZrB2, and 20.4 ± 1.9 vol% ZrC and its melting temperature was 2330 ± 23 °C. A ternary phase diagram for the SiC-ZrB2-ZrC was constructed and proposed via microstructural analysis of arc melted pellets on binary joins between each binary eutectic and the ternary eutectic in the system.\nJ. D. Jarman et al., \"Characterization of Fusion Welded Ceramics in the SiC-ZrB₂-ZrC System,\" Journal of the European Ceramic Society, vol. 41, no. 4, pp. 2255 - 2262, Elsevier, Apr 2021.\nThe definitive version is available at https://doi.org/10.1016/j.jeurceramsoc.2020.10.067\nMaterials Science and Engineering\nKeywords and Phrases\nBorides; Carbides; Joints/Joining; Phase Equilibria; Ultra-High Temperature Ceramics\nInternational Standard Serial Number (ISSN)\nArticle - Journal\n© 2021 European Ceramic Society, All rights reserved.\n01 Apr 2021", "domain": "chemistry", "round": 3} +{"url": "https://www.analyteguru.com/t5/Scientific-Library/Direct-identification-of-ligand-receptor-interactions-on-living/ta-p/7867", "date": "2023-03-30T18:06:23Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-14/segments/1679296949355.52/warc/CC-MAIN-20230330163823-20230330193823-00063.warc.gz", "language_score": 0.8196550011634827, "token_count": 354, "dump": "CC-MAIN-2023-14", "global_id": "webtext-fineweb__CC-MAIN-2023-14__0__114098973", "lang": "en", "text": "Frei AP, Jeon OY, Kilcher S, Moest H, Henning LM, Jost C, Plückthun A, Mercer J, Aebersold R, Carreira EM, Wollscheid B.\nNat Biotechnol. 2012 Oct 10;30(10):997-1001.\nMany cellular responses are triggered by proteins, drugs or pathogens binding to cell-surface receptors, but it can be challenging to identify which receptors are bound by a given ligand. Here we describe TRICEPS, a chemoproteomic reagent with three moieties-one that binds ligands containing an amino group, a second that binds glycosylated receptors on living cells and a biotin tag for purifying the receptor peptides for identification by quantitative mass spectrometry. We validated this ligand-based, receptor-capture (LRC) technology using insulin, transferrin, apelin, epidermal growth factor, the therapeutic antibody trastuzumab and two DARPins targeting ErbB2. In some cases, we could also determine the approximate ligand-binding sites on the receptors. Using TRICEPS to label intact mature vaccinia viruses, we identified the cell surface proteins AXL, M6PR, DAG1, CSPG4 and CDH13 as binding factors on human cells. This technology enables the identification of receptors for many types of ligands under near-physiological conditions and without the need for genetic manipulations.http://www.nature.com/nbt/journal/vaop/ncurrent/pdf/nbt.2354.pdf\nDepartment of Biology, Institute of Molecular Systems Biology, ETH Zurich, Switzerland.", "domain": "chemistry", "round": 3} +{"url": "https://research-information.bris.ac.uk/en/studentTheses/study-of-polymeric-micelles-as-a-drug-delivery-system-for-carrier", "date": "2023-03-26T02:52:11Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-14/segments/1679296945381.91/warc/CC-MAIN-20230326013652-20230326043652-00370.warc.gz", "language_score": 0.9299981594085693, "token_count": 499, "dump": "CC-MAIN-2023-14", "global_id": "webtext-fineweb__CC-MAIN-2023-14__0__184975741", "lang": "en", "text": "AbstractMany drugs have complex chemical properties which limit solubility in common solvents like water. Alternative formulations such as polymeric micelles formed by self-assembly of amphiphilic macromolecules may alleviate problems associated with bioavailability of poorly water-soluble drugs. The mechanisms underlying uptake and trafficking of polymeric micelles and the extent to which they are transported across epithelia remain largely unknown. This thesis provides insight into the nature of micellar drug delivery by focussing on the interactions of poloxamer P407 micelles and a model cargo with kidney and placental epithelia.\nFluorescent (RITC) poloxamer P407 micelles encapsulating DiO as a model fluorescent cargo were synthesised and characterised. The resultant micelles had a hydrodynamic diameter of 12nm and a critical micelle temperature of 25°C that was influenced by the presence of DiO. Fluorimetric analysis confirmed FRET between DiO and RITC that could be used to monitor cargo loading and release.\nThe kinetics of uptake and subcellular distribution of fluorescent micelles in epithelial cell lines (dog kidney MDCK and human placental BeWo b30 cells) was examined by confocal microscopy. Immunofluorescence identified punctate structures accumulating fluorescent micelles as late endosomes/lysosomes. Inhibition of receptor-mediated endocytosis partially blocked micelle uptake supporting the role of endocytosis in the process but suggesting the possible operation of alternative uptake pathways.\nMDCK and BeWo b30 cells were grown on permeable Transwell supports and their development into polarised epithelia with significant barrier function confirmed by microscopy and electrical resistance measurements. Fluorescent micelles were taken up by both polarised cell barrier models but in MDCKs the extent of endocytosis appeared reduced compared to non-polarised cells. A minor proportion of apically applied DiO-loaded micelles was transported across both cell barriers. BeWo cells were also cultured under flow to mimic physiological conditions. Preliminary data indicated flow affected morphological and functional differentiation and accelerated micelle uptake.\n|Date of Award||28 Nov 2019|\n|Supervisor||Mark A Jepson (Supervisor) & Margaret Saunders (Supervisor)|", "domain": "chemistry", "round": 3} +{"url": "https://millionsmarchharlem.com/215/concrete-soil-stabilizers-driving-infrastructure-excellence/", "date": "2024-04-22T05:51:12Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712296818081.81/warc/CC-MAIN-20240422051258-20240422081258-00212.warc.gz", "language_score": 0.8975531458854675, "token_count": 1456, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__51462755", "lang": "en", "text": "Defining Soil Stabilizers\nA soil stabilizer is a sophisticated chemical compound that binds soil particles forming a stable substance having the desired engineering qualities. This substance is broadly utilized in construction work, road development, land renewal, etc., and has transformed into a vital component of contemporary civil engineering. This piece will introduce the attributes of soil stabilizers, application sectors, and dedicated implementations.\nOperational Mechanism of Cement-Based Soil Stabilizer\nCement-based soil stabilizers chiefly consist of inorganic materials like cement, lime, gypsum, etc., in addition to some organic elements. The basic concept is that by blending these compounds with soil particles, physical and chemical interactions modify the outer properties of the soil particles, ultimately fusing them into a cohesive unit. The strengthening procedure of concrete concrete hardener can be categorized into a trio of stages: initial setting, hardening, and enhanced strength development. In the initial setting stage, the water in the concrete soil stabilizer vaporizes to form a basic clot; in the solidifying stage, the minerals in the cement encounter a hydration reaction with the water to create a denser agglomeration; and in the phase of strength enhancement, the durability of the cement-based soil stabilizer progressively escalates to achieve its ultimate value.\nCement-based soil stabilizers display the ensuing features and advantages:\n- Low cost: Concrete soil stabilizers are budget-friendly than typical concrete materials. This is ascribed to plentiful raw materials, inexpensive prices, and a simple manufacturing procedure.\n- Effortless erection: The building approach of concrete soil stabilizers is reasonably easy and does not require complex mechanical machinery or special expertise. Moreover, the solidifying stage does not require excessive moisture, resulting in diminished construction time period.\n- Effective malleability: Cement-based soil stabilizers showcase a level of malleability, permitting them to be molded into varied shapes and sizes according to design requirements.\n- Sustainability: The raw materials of cement-based soil stabilizers mostly comprise renewable resources, conforming with the idea of eco-friendly development. Moreover, it produces diminished byproducts during fabrication and use, resulting in lessened environmental contamination.\nNotwithstanding, specific factors should be taken into account when using cement-based soil stabilizers. For case, its low tensile strength renders it impractical for withstanding significant tensile pressures; its poor resistance to alkali makes it improper for use involving contact with alkaline substances; and its longevity could be affected by external variables (e.g., temperature, wetness, etc.). Hence, while opting for concrete stabilizers for soil, it’s crucial to apply a holistic viewpoint aligned with the existing situations, and then opt for proper methods and materials to ensure safety and steadiness for the building.\nApplication Sectors for Soil Stabilizers\nSoil stabilizers are multifaceted chemical elements that connect soil particles to build a robust substance with sought-after engineering characteristics. This compound is broadly utilized in building, road construction, land regeneration, and alternate domains, and has evolved into an essential feature of current civil engineering. Thus, what are the particular applications?\nFirstly, the Construction work Domain\nIn the field of building, soil stabilizers are frequently applied in fortifying edifice bases, generating wall materials, and recycling construction waste, among various applications.\nFortification of Structural Foundations\nIn civil engineering, the stability and load-bearing capability of the building foundation stand vital significance for building safety. Soil stabilizers can combine soil particles to construct foundations and base structures with high sturdiness and stability. For example, loess fortified with soil stabilizers can constitute a dependable foundation material for various buildings in loess regions.\nProduction of Wall Materials\nSoil stabilizers facilitate generation of novel wall elements, such as lightweight insulating bricks and walls. These walls satisfy building heat resistance needs, reducing energy usage and ecological contamination. As an example, new wall materials resulting from industrial byproducts such as rubble soil or tailings slag and enhanced with soil stabilizers can be utilized for waste utilization and expenditure reduction.\nUtilization of Construction Waste\nWith ongoing progression of the construction sector, creation of construction waste is also increasing. Soil stabilizers enable creation of composites with designated engineering qualities from construction waste, like concrete blocks, pavement bricks, etc. These composite materials not only reduce environmental contamination but also curb production costs.\nNext, the Highway Domain\nIn the realm of road infrastructure, soil stabilizers are commonly employed in road construction, parking lot creation, airport runway construction, and more.\nConstructing and Maintaining Roads\nSoil stabilizers can produce strengthened soil pavement base, displaying resilient bearing capacity and longevity. This makes them well-suited for building and maintaining diverse kinds of roads. For example, in mountainous or hilly regions, soil stabilizers can be employed to formulate road base materials, efficiently addressing road construction and management problems in hillside terrain.\nCreating Parking Lots\nSoil stabilizers enable development of parking lot surfaces exhibiting adequate load-bearing capacity, using industrial byproducts like rubble soil or tailings. These surfaces demonstrate positive environmental attributes and effectiveness in production costs.\nConstruction of Airport Runways\nFor aviation runway construction, soil stabilizers can be employed to create runway base layers showing solidity and bearing capacity. This is particularly useful in regions lacking of adequate land resources, addressing challenges related to runway development.\nLastly, the Domain of Land Restoration\nSoil stabilizers find common use in land reclamation and soil remediation contexts.\nIn areas subjected to mining, quarries, and comparable land disturbances, soil stabilizers facilitate the formulation of materials possessing specified engineering properties, promoting land reclamation and reuse. As an example, at a quarry site, applying soil materials fortified with soil stabilizers for rehabilitation can restore ecological functions and enhance land utilization.\nIn managing contaminated or eroded soil, soil stabilizers can be used to generate stabilized soil materials preventing further damage from pollutants or erosive agents. For example, in remediating soil contaminated with heavy metals, soil stabilizer-based stabilized soil substances can effectively sequester heavy metal ions, minimizing environmental pollution.\nIn conclusively, soil stabilizers offer a plethora of potential applications. As the world advances and technological advancement continues, the efficacy and range of soil stabilizers are anticipated to expand, supplying more effective engineering components and resolutions for human endeavors and manufacturing.\nConcrete Soil Stabilizer Supplier\nTRUNNANO is a reliable concrete additives supplier with over 12-year experience in nano-building energy conservation and nanotechnology development.\nIf you are looking for high-quality concrete additivesConcrete Soil Stabilizer, we have more than ten years of experience, please feel free to contact us and send an inquiry. ([email protected])\nWe accept payment via Credit Card, T/T, West Union, and Paypal. TRUNNANO will ship the goods to customers overseas through FedEx, DHL, by air, or by sea.", "domain": "chemistry", "round": 3} +{"url": "https://digitalcommons.unl.edu/biochemfacpub/449/", "date": "2021-09-26T21:27:48Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-39/segments/1631780057973.90/warc/CC-MAIN-20210926205414-20210926235414-00093.warc.gz", "language_score": 0.8843580484390259, "token_count": 434, "dump": "CC-MAIN-2021-39", "global_id": "webtext-fineweb__CC-MAIN-2021-39__0__242644301", "lang": "en", "text": "Date of this Version\nDuszenko N, Buan NR. 2017. Physiological evidence for isopotential tunneling in the electron transport chain of methane-producing archaea. Appl Environ Microbiol 83:e00950-17. https://doi.org/10 .1128/AEM.00950-17.\nMany, but not all, organisms use quinones to conserve energy in their electron transport chains. Fermentative bacteria and methane-producing archaea (methanogens) do not produce quinones but have devised other ways to generate ATP. Methanophenazine (MPh) is a unique membrane electron carrier found in Methanosarcina species that plays the same role as quinones in the electron transport chain. To extend the analogy between quinones and MPh, we compared the MPh pool sizes between two well-studied Methanosarcina species, Methanosarcina acetivorans C2A and Methanosarcina barkeri Fusaro, to the quinone pool size in the bacterium Escherichia coli. We found the quantity of MPh per cell increases as cultures transition from exponential growth to stationary phase, and absolute quantities of MPh were 3-fold higher in M. acetivorans than in M. barkeri. The concentration of MPh suggests the cell membrane of M. acetivorans, but not of M. barkeri, is electrically quantized as if it were a single conductive metal sheet and near optimal for rate of electron transport. Similarly, stationary (but not exponentially growing) E. coli cells also have electrically quantized membranes on the basis of quinone content. Consistent with our hypothesis, we demonstrated that the exogenous addition of phenazine increases the growth rate of M. barkeri three times that of M. acetivorans. Our work suggests electron flux through MPh is naturally higher in M. acetivorans than in M. barkeri and that hydrogen cycling is less efficient at conserving energy than scalar proton translocation using MPh.", "domain": "chemistry", "round": 3} +{"url": "https://textilestudycenter.com/electron-microscope/", "date": "2023-12-11T18:10:53Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679516047.98/warc/CC-MAIN-20231211174901-20231211204901-00675.warc.gz", "language_score": 0.8745614886283875, "token_count": 333, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__304318558", "lang": "en", "text": "There are two different types of electron microscopes, scanning electron microscopes (SEM) and transmission electron microscopes (TEM). In the TEM method, an electron beam passes through an extremely thin section of the specimen. You will get a two-dimensional cross-section of the specimen. SEMs, in contrast, visualize the surface structure of the specimen, providing a 3-D impression. The image above was produced by a SEM\nElectron microscope method\nThe electron microscope method is better to examine the surface of the fiber. By electron microscopy, only dry specimen can be examined. And the specimen must be very thin (less than 0.1μm). A limitation is that the specimens must be in a vacuum.\nThe basic principle is that a beam of electrons is generated by a suitable source. Then the beam scans the surface of the specimen. An image is shown on the monitor screen with spot.\nThe scanning electron microscope has the great advantage of a much larger depth of focus. In general, this gives much the same sort of information about orientation and crystallinity of fibers.\nProperties required for fiber forming polymer\n⦿Polymer should be soluble in some solvent from which it can be spun.\n⦿Hydroscopic nature should be hydrophilic.\n⦿Resistance to different chemicals\n⦿ should be near the room temperature.\n⦿ 200-300⁰C is suitable.\n⦿Orientation, following are suitable…..\n⨳ Long and straight chain structure\n⨳ Physical & chemical symmetry\n⨳ Parallel molecular chain", "domain": "chemistry", "round": 3} +{"url": "http://aaqr.org/article/detail/AAQR-18-08-OA-0320", "date": "2019-11-15T19:55:51Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-47/segments/1573496668712.57/warc/CC-MAIN-20191115195132-20191115223132-00543.warc.gz", "language_score": 0.9501532316207886, "token_count": 454, "dump": "CC-MAIN-2019-47", "global_id": "webtext-fineweb__CC-MAIN-2019-47__0__60300085", "lang": "en", "text": "Although some ambient Volatile Organic Compounds (VOCs) have been recognized to influence human health, the functional basis and underlying molecular mechanisms remain obscure. Here, the ambient VOCs and corresponding human genes response to the VOCs (HGRV) were analyzed integratedly from several aspects. (1) Firstly, through identifying composition and connectivity of functional groups within VOCs, we found that there is significant bias in the co-occurrence patterns among the top five frequent groups (respectively methyl, carbon-carbon double bond, benzene ring, chlorine and ethylene). For instances, co-occurrence of chlorine and benzene are considerably frequent, whereas the connection between chlorine and methyl/ethylene occurred rarely. (2) Then, by examining the screened HGRV, it was unveiled that four genes (respectively, IL6, BCL2, FOS and PTGS2) may act as “hub/hotspots” in response to VOCs. And four types of VOCs (respectively, Acetaldehyde, Butyraldehyde, Formaldehyde and Styrene) were found to be shared stimulators of the hubs. (3) Moreover, three dominant function categories were detected, respectively, response to lipopolysaccharide, response to molecule of bacterial origin and response to oxidative stress. (4) Further, the results disclosed that three most significant pathways are IL-17 signaling pathway, TNF signaling pathway and Rheumatoid arthritis. These three most significantly enriched pathways in HGRV are primarily associated with immune diseases and cancer. (5) Subsequently, by analyzing the diseases potentially associated with HGRV, the results revealed that 50 kinds of diseases might be significantly associated with HGRV. Among them, top 3 significant diseases are Immune system diseases, Cancers and Allergies and autoimmune diseases respectively. And these top 3 diseases might be induced by 13 common VOC species, such as Benzene, Chlorobenzene and Formaldehyde. Thus, the above findings could be useful for advancing our understanding of mechanisms related to diseases by VOCs exposure and development of control strategies to limit their damage or attenuate their sequelae.", "domain": "chemistry", "round": 3} +{"url": "https://exosome-rna.com/extracellular-vesicles-and-their-content-in-bioactive-lipid-mediators/", "date": "2024-04-14T05:35:55Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712296816864.66/warc/CC-MAIN-20240414033458-20240414063458-00066.warc.gz", "language_score": 0.9232847690582275, "token_count": 459, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__35381405", "lang": "en", "text": "Extracellular vesicles (EVs), such as exosomes and microvesicles, are small membrane-bound vesicles released by cells under various conditions. In a multitude of physiological and pathological conditions, EVs contribute to intercellular communication by facilitating exchange of material between cells. Rapidly growing interest is aimed at better understanding EV function and their use as biomarkers. The vast EV cargo includes cytokines, growth factors, organelles, nucleic acids (messenger and micro RNA), and transcription factors. A large proportion of research dedicated to EVs is focused on their microRNA cargo; however, much less is known about other EV constituents, in particular eicosanoids. These potent bioactive lipid mediators, derived from arachidonic acid, are shuttled in EVs along with the enzymes in charge of their synthesis. In the extracellular milieu, EVs also interact with secreted phospholipases to generate eicosanoids, which then regulate the transfer of cargo into a cellular recipient. Eicosanoids are useful as biomarkers and contribute to a variety of biological functions, including modulation of distal immune responses. Here, researchers from the Université Laval discuss the reported roles of eicosanoids conveyed by EVs and describe their potential as biomarker.\nEicosanoids and the associated enzymes are comprised in extracellular vesicles\nCells produce different types of extracellular vesicles (EV), such as exosomes, and microvesicles.Exosomes are stored in multivesicluar bodies (MVB) and released on cell activation whereas microvesicles are generated by plasma membrane budding and shedding.Graphic representation of the metabolism of AA into eicosanoids. AA; arachidonic acid, Cox-1; cyclooxygenase-1, Cox-2; cyclooxygenase-2, TxS; thromboxane synthase, 12-LO; 12-lipoxygenase, 5-LO; 5-lipoxygenase, LT; leukotriene, PG; prostaglandin, HETE; hydroxyeicosatetraenoic acid.", "domain": "chemistry", "round": 3} +{"url": "https://www.creativebiomart.net/native-bovine-fgf2-protein-503740.htm", "date": "2019-10-21T14:55:37Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-43/segments/1570987779528.82/warc/CC-MAIN-20191021143945-20191021171445-00304.warc.gz", "language_score": 0.7023183703422546, "token_count": 357, "dump": "CC-MAIN-2019-43", "global_id": "webtext-fineweb__CC-MAIN-2019-43__0__64751672", "lang": "en", "text": "|Product Overview:||Native Bovine FGF2 Protein is purified from Bovine brain tissue.|\n|Form:||Lyophilized from a 0.2 μm filtered solution in Tris-HCl and NaCl with BSA as a carrier protein.|\n|Bio-activity:||Measured in a cell proliferation assay using NR6R‑3T3 mouse fibroblast cells. Rizzino, A. et al. (1988) Cancer Res. 48:4266; Thomas, K. et al. (1987) Methods Enzymol. 147:120. The ED50 for this effect is 0.125-0.625 ng/mL.|\n|Molecular Mass:||18 kDa|\n|Endotoxin:||<1.0 EU per 1 μg of the protein by the LAL method.|\n|Purity:||>97%, by SDS-PAGE under reducing conditions and visualized by silver stain|\n|Storage:||Avoid repeated freeze-thaw cycles.\n12 months from date of receipt, -20 to -70 centigrade as supplied.\n1 month, 2 to 8 centigrade under sterile conditions after reconstitution.\n3 months, -20 to -70 centigrade under sterile conditions after reconstitution.\n|Reconstitution:||Reconstitute at 100 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.|\n|Gene Name:||fibroblast growth factor 2 [ Bos taurus (cattle) ]|\n|Synonyms:||BFGF; FGF-2; HBGF-2|", "domain": "chemistry", "round": 3} +{"url": "https://www.booktopia.com.au/ionic-polymerizations-and-related-processes-judit-e-puskas/prod9780792358121.html", "date": "2019-04-18T13:22:22Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-18/segments/1555578517639.17/warc/CC-MAIN-20190418121317-20190418143317-00555.warc.gz", "language_score": 0.7784769535064697, "token_count": 728, "dump": "CC-MAIN-2019-18", "global_id": "webtext-fineweb__CC-MAIN-2019-18__0__126314914", "lang": "en", "text": "In Ionic Polymerization and Related Processes, internationally recognised academic and industrial researchers discuss and debate the latest developments in the field. The major focus is on cationic polymerizations, but related anionic and controlled radical processes are also discussed.\nPreface. Program. List of Participants. List of Contributors (Lecturers). Part I: Cationic Polymerization. Cationic Polymerizations at Elevated Temperatures by Novel Initiating Systems Having Weakly Coordinating Counteranions. 1. High Molecular Weight Polyisobutylenes; Z. Pi, et al. Cationic Polymerization: Industrial Processes and Applications; R.J. Pazur, H.H. Greve. New Branched Polyisobutenes and Butyl Rubbers by the Inimer Method; G. Langstein, et al. Newer Aspects of Photoinitiated Cationic Polymerization; J.V. Crivello. Cationic Macromolecular Design using Non(homo)polymerizable Monomers; Y.C. Bae, et al. Segmented Polymer Networks by Cationic Polymerization: Design and Applications; F.E. Du Prez, E.J. Goethals. Rate Constants and Reactivity Ratios in Carbocationic Polymerizations; H. Mayr. Photochemically Induced Cationic Photopolymerization of Vinyl Ethers and Oxethanes; O. Nuyken, M. Ruile. Kinetics of the Living Polymerization of Isobutylene; J.E. Puskas, et al. Kinetics and Mechanism of Living Cataionic Polymerization of Olefins; R.F. Storey, et al. Stopped-flow Technique and Cationic Polymerization Kinetics; J.P. Vairon, et al. Photoinitiated Cationic Polymerization; Y. Yagci. Part II: Anionic and Other Related Processes. A Forgotten Class of High Tg Thermoplastic Materials: Anionic Copolymers of Styrene and 1,1-Diphenylethylene. Synthesis, Toughening and Block Copolymerization with Butadiene; K. Knoll, et al. Control of Active Centers Reactivity in the High Temperature Bulk Anionic Polymerization of Hydrocarbon Monomers; A. Deffieux, et al. Arborescent Polymers: Highly Branched Homo- and Copolymers with Unusual Properties; M. Gauthier. Similarities and Discrepancies between Controlled Cationic and Radical Polymerizations; K. Matyjaszewski. Recent Developments in Anionic Synthesis of Model Graft Copolymers; J. Mays. Kinetics of Elementary Reactions in Cyclic Ester Polymerization; S. Penczek, et al. Synthesis and Properties of Amphiphilic and Functional Copolymers and Networks; R. Velichkova, et al. Modeling, Simulation and Control of Polymerization Processes: Some Aspects for Tailored Synthesis; A.F. Johnson, et al. Conference Photos.\nSeries: NATO Asi Series. Series E, Applied Sciences\nNumber Of Pages: 368\nPublished: 30th June 1999\nCountry of Publication: NL\nDimensions (cm): 23.39 x 15.6\nWeight (kg): 0.58", "domain": "chemistry", "round": 3} +{"url": "https://ubir.buffalo.edu/xmlui/handle/10477/50956", "date": "2018-07-18T22:36:14Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-30/segments/1531676590329.62/warc/CC-MAIN-20180718213135-20180718233135-00160.warc.gz", "language_score": 0.8861457109451294, "token_count": 344, "dump": "CC-MAIN-2018-30", "global_id": "webtext-fineweb__CC-MAIN-2018-30__0__90410081", "lang": "en", "text": "The evaluation of anti-cancer effects of FL118 in retinoblastoma in monotherapy and combination therapies\nSingh, Jasman Kaur\nMetadataShow full item record\nRecently, the novel small chemical molecule FL118 has been reported and seems a promising agent because of its superior anti-tumor activity in head and neck cancer in vivo and in colon cancer cells in vitro . FL118 has shown to specifically inhibit anti-apoptotic proteins (e.g. survivin ) and induce pro-apoptotic proteins (e.g. Bax and Bim ) 7 . Also, FL118 cell killing is mediated regardless of the p53 status. Here, we investigated the mechanism of action of FL118 in retinoblastoma in monotherapy and in combination therapy with the well-established topoisomerase inhibitor topotecan 23 and the platinum-based agent cisplatin 26 . In addition, we generated p53 and Mdmx gene knockdown models in vitro in retinoblastoma tumor cells to study the effect of these genes on FL118 cytotoxicity. We observed a synergistic effect of the combination therapy according to one single experiment. We observed that p53 plays a significant role in FL118 drug cytotoxicity and Mdmx slightly modifies FL118 cytotoxicity. In addition, Fl118 activates p53 via an ATM-independent manner, but the exact mechanism of p53 activation still remains unknown. We believe FL118-based mono- and combination therapies merit further investigations in more retinoblastoma cell lines, and new knowledge on this novel compound will hopefully lead to its clinical trials for improved cancer treatment in the future.", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/rubella-virus-strain-hpv77-antibody-hrp-ab156669.html", "date": "2019-04-24T06:14:47Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-18/segments/1555578633464.75/warc/CC-MAIN-20190424054536-20190424075611-00081.warc.gz", "language_score": 0.7942081093788147, "token_count": 656, "dump": "CC-MAIN-2019-18", "global_id": "webtext-fineweb__CC-MAIN-2019-18__0__179827825", "lang": "en", "text": "Product nameAnti-Rubella virus strain HPV77 antibody (HRP)\nDescriptionGoat polyclonal to Rubella virus strain HPV77 (HRP)\nSpecificityab156669 is specific to purified virions of Rubella virus.\nTested applicationsSuitable for: WB, ELISA, IHC-Pmore details\nSpecies reactivityReacts with: Other species\nTissue/cell preparation of Rubella virus strain HPV77.\n- ab156669 consists of purified IgG fraction of antiserum covalently coupled to a highly purified preparation of horseradish peroxidase.\nGeneral notesProtein concentration is 1-2 mg/ml.\nEstimated molar HRP:IgG substitution is 2-3.\nStorage instructionsShipped at 4°C. Store at +4°C.\nStorage bufferPreservative: 0.002% Thimerosal (merthiolate)\nConstituents: 98% PBS, 1% BSA\nConcentration information loading...\n- TMB ELISA Substrate (Highest Sensitivity) (ab171522)\n- TMB ELISA Substrate (High Sensitivity) (ab171523)\n- TMB ELISA Substrate (Fast Kinetic Rate) (ab171524)\n- TMB ELISA Substrate (Slow Kinetic Rate) (ab171525)\n- TMB ELISA Substrate (Slower Kinetic Rate) (ab171526)\n- TMB ELISA Substrate (Slowest Kinetic Rate) (ab171527)\n- 450 nm Stop Solution for TMB Substrate (ab171529)\n- 650 nm Stop Solution for TMB Substrate (ab171531)\n- Immunoassay Blocking Buffer (ab171534)\n- Immunoassay Blocking (BSA Free) (ab171535)\nOur Abpromise guarantee covers the use of ab156669 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\n|WB||1/20 - 1/200.|\n|ELISA||1/200 - 1/1000.|\n|IHC-P||1/20 - 1/200.|\nRelevanceRubella is the only Togavirus known to be transmitted via the respiratory route, and the disease with which it is associated, Rubella or \"German Measles\" was once ubiquitous in human populations. Rubella virus can also act as a teratogen, inducing Congenital Rubella Syndrome when spread from mother to fetus in the first trimester of pregnancy. Rubella virus is spread via respiratory transmission from human to human. Virus is shed in oropharyngeal secretions and is highly transmissible. In communities where vaccination is rare, spring outbreaks typically occur every few years. In these communities, children represent the largest number of cases, as adults usually acquire lifelong immunity after the primary infection.\nab156669 has not yet been referenced specifically in any publications.", "domain": "chemistry", "round": 3} +{"url": "https://www.gothermal.co.za/collections/flir-optical-gas-imaging", "date": "2019-06-17T11:38:00Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-26/segments/1560627998473.44/warc/CC-MAIN-20190617103006-20190617125006-00167.warc.gz", "language_score": 0.8855897188186646, "token_count": 280, "dump": "CC-MAIN-2019-26", "global_id": "webtext-fineweb__CC-MAIN-2019-26__0__7074947", "lang": "en", "text": "FLIR optical gas imaging (OGI) cameras can help you detect methane, sulfur hexafluoride, and hundreds of other industrial gases quickly, accurately, and safely - without shutting down systems. With FLIR OGI cameras, you can scan broad sections of equipment rapidly and survey areas that are hard to reach with traditional contact measurement tools. OGI cameras can also detect leaks from a safe distance, displaying these invisible gases as clouds of smoke.\nSee hydrocarbon leaks clearly\nScan thousands of connections for natural gas (methane) and other hydrocarbon leaks quickly and from a safe distance to avoid regulatory violations, fines, and lost revenue.\nFind SF6 leaks easily\nScan substation circuit breakers for sulfur hexafluoride (SF6) leaks at a safe distance from high-voltage areas, without the need to shut down operations.\nFind leaks at steel plants\nProtect workers and the environment from toxic levels of carbon monoxide (CO) by pinpointing leaks quickly and efficiently\nDetect leaks from hydrogen-cooled generators\nImaging the tracer gas, CO2, with an optical gas camera allows operators of hydrogen-cooled generators to efficiently find hydrogen leaks.\nDetect R-124 compressor leaks\nFind leaks early to avoid interruptions in operations, prevent the loss of perishable products, and limit the environmental impact of toxic refrigerants.", "domain": "chemistry", "round": 3} +{"url": "http://webprogrammingsolution.com/what-are-pfass-and-is-your-non-stick-pan-making-you-fat/", "date": "2018-10-19T16:58:16Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-43/segments/1539583512411.13/warc/CC-MAIN-20181019145850-20181019171350-00133.warc.gz", "language_score": 0.9526016712188721, "token_count": 772, "dump": "CC-MAIN-2018-43", "global_id": "webtext-fineweb__CC-MAIN-2018-43__0__52347321", "lang": "en", "text": "Chemical compounds used to make merchandise resembling non-stick kitchen pans have been linked to weight problems in a brand new examine.\nResearchers at Harvard imagine that perfluoroalkyl substances (PFASs) within the bloodstream may disturb how the physique regulates weight by reducing the resting metabolic charge. Meaning the physique burning energy extra slowly than common, which means an individual must eat much less to keep away from changing into obese.\nPrevious research have linked the chemical compounds known as “obesogens” with extra weight acquire, most cancers, excessive ldl cholesterol, immune issues, and weight problems in animals.\n“Now, for the primary time, our findings have revealed a novel pathway via which PFASs would possibly intrude with human physique weight regulation and thus contribute to the weight problems epidemic,” mentioned senior writer Qi Solar, assistant professor within the Division of Diet at Harvard Chan College and writer of the examine printed within the journal Plos Medication.\nTo reach at their conclusions, researchers assessed knowledge from 621 obese and overweight individuals who took half in scientific trial investigating weight reduction diets within the mid-2000s. The researchers discovered that those that regained essentially the most weight after quitting the diets had decrease resting metabolic charges and the best concentrations of PFASs of their blood. Ladies particularly seemed to be most affected.\n“We sometimes take into consideration PFASs by way of uncommon well being issues like most cancers, however it seems they’re additionally taking part in a job in weight problems, a serious well being downside going through hundreds of thousands across the globe,” mentioned examine co-author Philippe Grandjean, adjunct professor of environmental well being at Harvard Chan College.\n“The findings recommend that avoiding or lowering PFASs publicity might assist individuals preserve a steady physique weight after they efficiently lose some weight, particularly for ladies.”\nWhat are PFASs used for?\nFor over six many years, PFASs have been used to make merchandise together with cookware, upholstered furnishings and carpets, sneakers, and mattresses. They’re additionally used on airfields and different websites prone to petrol fires, based on the US Environmental Protection Agency, in addition to in heavy equipment to cut back friction.\nAnalysis has proven that such chemical compounds have additionally seeped into the water close to industrial websites, army bases and water therapy crops. As they aren’t biodegradable, PFASs can linger within the physique for a very long time.\nHow simple is it to keep away from them?\nAs a result of their widespread use and the very fact they aren’t damaged down by air, water or daylight, it’s doubtless most individuals have come into low-level contact with PFASs, based on the EPA.\nA separate study at Harvard in 2016 discovered that over 16m Individuals drink water contaminated with PFASs.\nIn recent times, producers have seemed in direction of changing PFASs with plant-based chemical compounds, HuffPost reported.\nOught to we be fearful?\nIn 2015, over 200 scientists from 38 completely different international locations signed a doc often known as the Madrid Assertion, which warned of the possibly dangerous results of PFASs.\nNonetheless, Alan Boobis, professor of toxicology at Imperial School, London, informed The Guardian that additional analysis was wanted to make a causal hyperlink between PFASs and weight acquire.\n“Because the authors level out, there may be the potential that not less than among the findings are because of likelihood. The findings can function a very good foundation for additional, extra targeted investigations right into a attainable hyperlink between publicity to PFASs and weight administration,” he mentioned.", "domain": "chemistry", "round": 3} +{"url": "http://medicaljournal.gazi.edu.tr/index.php/GMJ/article/view/1233", "date": "2020-08-04T00:19:20Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-34/segments/1596439735836.89/warc/CC-MAIN-20200803224907-20200804014907-00433.warc.gz", "language_score": 0.7597882151603699, "token_count": 2462, "dump": "CC-MAIN-2020-34", "global_id": "webtext-fineweb__CC-MAIN-2020-34__0__157539831", "lang": "en", "text": "The Evaluation of Formaldehyde Exposure in the Anatomy Laboratories and the Preventive Measures\nAbstractObjective: Our aim is to evaluate the studies about formaldehyde exposure in anatomy laboratories at faculties of medicine all over the world reported from 2000 to 2013.Materials and Methods: In this research, formaldehyde exposure of medical students and researchers in the anatomy laboratories of faculties of medicine studies, which were reported in Pubmed database from 2000 to 2013, were reviewed and classified clinical symptoms, environmental monitoring and preventive measures.Results: There are 27 studies on formaldehyde exposure from anatomy laboratories of various faculties of medicine 15 (55.6%) of which are clinical symptom studies whereas 12 (44.4%) are environmental monitoring of formaldehyde exposure. Conclusion: Considering the fact that lower levels of exposure to formaldehyde is associated with cytogenetic changes in epithelial cells of the nasal region, long-term exposure to formaldehyde in the anatomy laboratories poses risks of nasopharynx and nasal cavity cancers. Medical students and instructors working in anatomy laboratories should take concrete measures to reduce exposure to formaldehyde\nSouza AD, Devi R. Cytokinesis blocked micronucleus assay of peripheral lymphocytes revealing the genotoxic effect of formaldehyde exposure. Clin Anat 2014; 27:308-12. 2. Costa DL, Amdur MO. Air pollution. In: Klaassen CD, eds. Casarett and Doull’s Toxicology: The Basic Science of Poisons. New York: McGraw-Hill, 1996. p 857-82.\nMirabelli MC, Holt SM, Cope JM. Anatomy laboratory instruction and occupational exposure to formaldehyde. Occup Environ Med 2011: 68: 375-78.\nAgency For Toxic Substances and Disease Registry (ATSDR). Toxicological Profile for Formaldehyde. Atlanta, 1999. p1- 468.\nInternational Agency for Research on Cancer (IARC). Formaldehyde, 2-butoxyethanol and 1-tert-butoxypropan-2-ol. IARC Monogr Eval Carcinog 3 Risks Hum, 2006. 88: 1-478.\nNational Toxicology Program. Final report on carcinogens background document for formaldehyde. Rep Carcinog Backgr Doc, 10-5981, 2010. p-512.\nBrenner E. Human body preservation - old and new techniques. J Anat 2014 ; 224(3): 316-44. 8. Suruda A. Morticians. In: Occupational, Industrial, and Environmental Toxicology. (eds Greenberg MI, Hamilton RJ, Phillips SD, McCluskey GJ), Philadelphia, PA: Mosby Inc. 2003. P 274–83.\nLakchayapakon K, Watchalayarn P. Formaldehyde exposure of medical students and instructors and clinical symptoms during gross anatomy laboratory in Thammasat University. J Med Assoc Thai 2010: 93 Suppl 7:S92-98.\nVimercati L, Carrus A, Martino T, Galise I, Minunni V, Caputo F, et al. Formaldehyde exposure and irritative effects on medical examiners, pathologic anatomy post-graduate students and technicians. Iran J Public Health. 2010; 39:26-4.\nKunugita N, Nakashima T, Kikuta A, Kawamoto T, Arashidani K. Exposure to formaldehyde during an anatomy dissecting course. J UOEH 2004; 26:337-48.\nTanaka K, Nishiyama K, Yaginuma H, Sasaki A, Maeda T, Kaneko SY, et al. Formaldehyde exposure levels and exposure control measures during an anatomy dissecting course. Kaibogaku Zasshi 2003; 78:43-51.\nOnyije FM, Avwioro OG. Excruciating effect of formaldehyde exposure to students in gross anatomy dissection laboratory. Int J Occup Environ Med. 2012; 3:92-5.\nMori M, Hoshiko M, Hara K, Saga T, Yamaki K, Ishitake T. Changes in subjective symptoms and allergy state among medical students exposed to low-level formaldehyde 6 months after completion of a gross anatomy dissection course. Environ Health Prev Med 2013; 18:386-93.\nTakahashi S, Tsuji K, Fujii K, Okazaki F, Takigawa T, Ohtsuka A, et al. Prospective study of clinical symptoms and skin test reactions in medical students exposed to formaldehyde gas. J Dermatol 2007; 34:283-89.\nMizuki M, Tsuda T. Relationship between atopic factors and physical symptoms induced by gaseous formaldehyde exposure during an anatomy dissection course. Arerugi. 2001;50:21-8.\nWantke F, Focke M, Hemmer W, Bracun R, Wolf-Abdolvahab S, Götz M, et al. Exposure to formaldehyde and phenol during an anatomy dissecting course: sensitizing potency of formaldehyde in medical students. Allergy 2000; 55:84-7.\nKhaliq F, Tripathi P. Acute effects of formalin on pulmonary functions in gross anatomy laboratory. Indian J Physiol Pharmacol 2009; 53:93-6.\nOstojić L, Bradarić A, Mise K, Ostojić Z, Lovrić J, Petrović P, et al. Pulmonary function in persons who are professionally exposed to formaldehyde fumes. Coll Antropol 2006; 30:507-11.\nKriebel D, Myers D, Cheng M, Woskie S, Cocanour B. Short-term effects of formaldehyde on peak expiratory flow and irritant symptoms. Arch Environ Health 2001; 56:11-8.\nSakamoto T, Miyake M. Health effects of formaldehyde, as an indoor air pollutant. Kaibogaku Zasshi 2010; 85:35-41.\nUchiyama I. Toxicity of formaldehyde exposure and the details of its control measures. Kaibogaku Zasshi 2010; 85:29-34.\nVohra MS. Personal formaldehyde exposure level in the gross anatomy dissecting room at College of Medicine King Saud University Riyadh. Int J Occup Med Environ Health 2011; 24:108-13.\nKikuta A, Yamato H, Kunugita N, Nakashima T, Hayashi H. Reducing the levels of formaldehyde exposure during a gross anatomy dissection course with a local ventilation system. Kaibogaku Zasshi 2010; 85:17-27.\nOhmichi K, Matsuno Y, Miyaso H, Yamamoto H, Toriuchi M, Shimane M, et al..Pilot study of a dissection table for gross anatomy laboratory equipped with a photocatalytic device that decomposes formaldehyde. J Occup Health 2007; 49:499-03.\nWhitehead MC, Savoia MC. Evaluation of methods to reduce formaldehyde levels of cadavers in the dissection laboratory. Clin Anat. 2008; 21:75-81.\nYamato H, Nakashima T, Kikuta A, Kunugita N, Arashidani K, Nagafuchi Y, et al. A novel local ventilation system to reduce the levels of formaldehyde exposure during a gross anatomy dissection course and its evaluation using real-time monitoring. J Occup Health 2005; 47:450-53.\nProietti L, Sandonà PB, Longo B, Gulino S, Duscio D. Occupational exposure to formaldehyde at a service of pathologic anatomy. G Ital Med Lav Ergon 2002; 24:32-4.\nKeil CB, Akbar-Khanzadeh F, Konecny KA. Characterizing formaldehyde emission rates in a gross anatomy laboratory. Appl Occup Environ Hyg 2001; 6:967-72.\nKurose T, Kodera H, Aoyama H, Kawamata S. Formaldehyde concentration in the air and in cadavers at the gross anatomy laboratory in Hiroshima University. Hiroshima J Med Sci. 2004; 53:33-7.\nOhmichi K, Komiyama M, Matsuno Y, Takanashi Y, Miyamoto H, Kadota T, et al. Formaldehyde exposure in a gross anatomy laboratory--personal exposure level is higher than indoor concentration. Environ Sci Pollut Res Int 2006; 13:120-24.\nAhmed HO. Preliminary study: Formaldehyde exposure in laboratories of Sharjah university in UAE. Indian J Occup Environ Med 2011; 15:33-7.\nTakayanagi M, Sakai M, Ishikawa Y, Murakami K, Kimura A, Kakuta S, et al. Formaldehyde concentrations in the breathing zone of medical students during gross anatomy laboratory in Toho University. Kaibogaku Zasshi 2007; 82:45-51.\nViegas S, Ladeira C, Nunes C, Malta-Vacas J, Gomes M, Brito M, et al. Genotoxic effects in occupational exposure to formaldehyde: A study in anatomy and pathology laboratories and formaldehyde-resins production. J Occup Med Toxicol 2010; 20;5:25.\nJapanese Ministry of Health, Labour and Welfare (MHLW). Guidelines for reducing formaldehyde concentrations in Indoor air of workplace, Tokyo, 2002, pp. 3- 90.\nArts JH, Muijser H, Kuper CF, Woutersen RA. Setting an indoor air exposure limit for formaldehyde: factors of concern. Regul Toxicol Pharmacol 2008; 52:189-94.\nJames H. Bedino (2004) Research, Formaldehyde Exposure Hazards and Health Effects: A Comprehensive Review for embalmers, The Champion Expanding Encyclopedia of Mortuary Practices, Encyclopedia, 650, p. 2636- 37.\nLu K, Collins LB, Ru H, Bermudez E, Swenberg JA. Distribution of DNA adducts caused by inhaled formaldehyde is consistent with induction of nasal carcinoma but not leukemia. Toxicol Sci. 2010; 116:441-51.\nBurgaz S, Erdem O, Cakmak G, Erdem N, Karakaya A, Karakaya AE. Cytogenetic analysis of buccal cells from shoe-workers and pathology and anatomy laboratory workers exposed to n-hexane, toluene, methyl ethyl ketone and formaldehyde. Biomarkers 2002; 7:151-61.\nBurgaz S, Cakmak G, Erdem O, Yilmaz M, Karakaya AE. Micronuclei frequencies in exfoliated nasal mucosa cells from pathology and anatomy laboratory workers exposed to formaldehyde. Neoplasma 2001; 48:144-47.\nMori M, Hoshiko M, Hara K, Ishitake T, Saga T, Yamaki K. Effect of large-scale repair work on indoor formaldehyde levels upon and subjective symptoms in, medical students during gross anatomy dissection course. Nihon Eiseigaku Zasshi 2012; 67:501-07.\nColeman R. Reducing the levels of formaldehyde exposure in gross anatomy laboratories. Anat Rec 1995; 243:531-33.\nAll opinions and reports within the articles that are published in the Gazi Medical Journal are the personal opinions of author(s). Gazi University, Editors and the publisher do not accept any responsibility for these articles. The journal is printed on acid-free paper.", "domain": "chemistry", "round": 3} +{"url": "https://pubmed.ncbi.nlm.nih.gov/10208650/?dopt=Abstract", "date": "2021-12-07T00:19:50Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-49/segments/1637964363327.64/warc/CC-MAIN-20211206224536-20211207014536-00166.warc.gz", "language_score": 0.913549542427063, "token_count": 589, "dump": "CC-MAIN-2021-49", "global_id": "webtext-fineweb__CC-MAIN-2021-49__0__170877045", "lang": "en", "text": "The NAD(P)H:quinone oxidoreductase 1 (NQO1) genotype-phenotype relationship was examined in individuals with a polymorphism in NQO1. The polymorphism comprises a C to T base change at position 609 of the human NQO1 cDNA (C609T) and codes for a proline to serine substitution in the amino acid structure of the NQO1 protein. Genotyping was performed by polymerase chain reaction-restriction fragment length polymorphism analysis of genomic DNA. Phenotyping was performed using enzyme activity assays and/or immunoblotting of human tumor cell lines and of saliva and bone marrow samples from healthy donors. Phenotyping of uninvolved lung and lung tumors from archived biopsy material was performed by immunohistochemistry. NQO1 activity and protein could be detected in wild-type (C/C) human tumor cells (HT-29) under conditions where NQO1 protein could not be detected in cells (BE) homozygous for the C609T change (T/T). Trace levels of NQO1 protein could be detected in BE cells; however, when immunoblots were subjected to chemiluminescence detection for prolonged periods. In saliva samples from 11 individuals carrying the homozygous C609T change (T/T), no NQO1 protein could be detected even after prolonged chemiluminescence detection. The amount of NQO1 protein present in saliva was quantified and found to be significantly less in heterozygous individuals (C/T) than in wild-type individuals (C/C). In bone marrow stromal cultures, both NQO1 activity and protein could be detected in heterozygotes (C/T) and in wild-type (C/C) samples. In a bone marrow stromal culture from an individual genotyped as T/T at position 609, no NQO1 protein or activity could be detected. NQO1 is elevated in non-small cell lung cancers and could be readily observed as intense immunostaining throughout lung adenocarcinomas genotyped as C/C but no immunostaining could be detected in adenocarcinomas genotyped as T/T at position 609. NQO1 is expressed in normal human lung but is localized to respiratory epithelium and to vascular endothelium. In normal lung tissue from individuals genotyped as T/T, no or faint immunostaining for NQO1 could be detected in either respiratory epithelium or vascular endothelium. These results demonstrate that tissues from individuals homozygous for the C609T change have no detectable or, at best, only trace amounts of NQO1 protein and are devoid of NQO1 activity.", "domain": "chemistry", "round": 3} +{"url": "https://www.bocsci.com/blu9931-cas-1538604-68-0-item-470871.html", "date": "2019-11-15T18:43:47Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-47/segments/1573496668699.77/warc/CC-MAIN-20191115171915-20191115195915-00232.warc.gz", "language_score": 0.7649931907653809, "token_count": 574, "dump": "CC-MAIN-2019-47", "global_id": "webtext-fineweb__CC-MAIN-2019-47__0__37067223", "lang": "en", "text": "|Description||BLU9931 is a potent and irreversible small-molecule inhibitor of FGFR4, as a targeted therapy to treat patients with HCC whose tumors have an activated FGFR4 signaling pathway. BLU9931 is exquisitely selective for FGFR4 versus other FGFR family members and all other kinases.|\n|B0084-470871||25 mg||$198||In stock|\n|Synonyms||BLU9931; BLU-9931; BLU 9931.|\n|Solubility||Soluble in DMSO, not in water|\n|Storage||Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).|\n|Shelf Life||2 years if stored properly|\nARQ-087, also known as Derazantinib, is an oral fibroblast growth factor receptor (FGFR) inhibitor with antitumor property. FGFR plays a role in the regulation ...\nFibroblast Growth Factor-Basic\nFibroblast Growth Factor-Basic is a growth factor encoded by the FGF2 gene. It is found in basement membranes and sub-endothelial extracellular matrix. FGF2 spe...\nSKLB610 is a VEGFR inhibitor that potently suppresses human tumor angiogenesis. SKLB610 inhibited angiogenesis-related tyrosine kinase VEGFR2, fibroblast growth...\nNintedanib (BIBF 1120) is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50 of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59...\nBLU9931 is a potent and irreversible small-molecule inhibitor of FGFR4, as a targeted therapy to treat patients with HCC whose tumors have an activated FGFR4 si...\nFGF-401 is an inhibitor of human fibroblast growth factor receptor 4 (FGFR4) (IC50= 1.9 nM) developed for the treatment of solid tumor.\nPD173074 is a small-molecule FGFR3-selective tyrosine kinase inhibitor (TKI), as a therapeutic modality using eight UC cell lines. PD173074 suppressed cell prol...\nPD-161570 is a selective inhibitor of human FGF-1 receptor tyrosine kinase, with IC50 values to be 40, 262 and 3700 nM for FGFR1, PDGFR and EGFR tyrosine kinase...", "domain": "chemistry", "round": 3} +{"url": "https://acs.figshare.com/articles/journal%20contribution/Alkyl_Effects_on_the_Chain_Initiation_Efficiency_of_Olefin_Polymerization_by_Cationic_Half_Sandwich_Scandium_Catalysts_A_DFT_Study/3116986/1", "date": "2020-11-24T18:54:27Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-50/segments/1606141176922.14/warc/CC-MAIN-20201124170142-20201124200142-00546.warc.gz", "language_score": 0.8819121718406677, "token_count": 384, "dump": "CC-MAIN-2020-50", "global_id": "webtext-fineweb__CC-MAIN-2020-50__0__125353303", "lang": "en", "text": "Alkyl Effects on the Chain Initiation Efficiency of Olefin Polymerization by Cationic Half-Sandwich Scandium Catalysts: A DFT Study\njournal contributionposted on 16.03.2016, 18:03 by Xiaohui Kang, Guangli Zhou, Xingbao Wang, Jingping Qu, Zhaomin Hou, Yi Luo\nAny type of content formally published in an academic journal, usually following a peer-review process.\nThe effect of alkyls on the chain initiation efficiency of ethylene, propene, 1-hexene, styrene, butadiene, and isoprene polymerizations catalyzed by the half-sandwich cationic rare-earth-metal alkyl complexes [(η5-C5Me5)ScR]+ (R = CH2SiMe3, 1; R = o-CH2C6H4NMe2, 2; R = η3-C3H5, 3) has been studied by using a DFT approach. It has been found that 2 with the largest sterically demanding aminobenzyl group results in the lowest initiation efficiency and thus longest induction period among the three catalysts investigated. In contrast, 1 with CH2SiMe3 displays the best chain initiation ability, and 3 with η3-allyl gives moderate chain initiation activity, mainly due to the most stable resulting coordination complex. Species 1 and 3 have better regioselectivity in the chain initiation of styrene polymerization than species 2. In addition, species 1′ ([(η5-C5Me5)Sc(CH2SiMe3)THF]+) with a THF ligand has better chain initiation efficiency in styrene and isoprene polymerizations than species 2 but is reasonably worse than the analogue 1 without a THF ligand.", "domain": "chemistry", "round": 3} +{"url": "http://ssf.f15ijp.com/wiki/index.php/Propanidid", "date": "2023-02-04T21:21:33Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-06/segments/1674764500154.33/warc/CC-MAIN-20230204205328-20230204235328-00714.warc.gz", "language_score": 0.7697258591651917, "token_count": 696, "dump": "CC-MAIN-2023-06", "global_id": "webtext-fineweb__CC-MAIN-2023-06__0__71424373", "lang": "en", "text": "|Systematic (IUPAC) name|\n|ATC code||N01AX04 (WHO)|\n|Molar mass||337.411 g/mol[[Script error: No such module \"String\".]]|\nEven though Cremophor EL has been shown to cause anaphylactic reactions in humans in several cases (both when given intravenously and orally), it is still debated whether or not propanidid itself may have contributed to the reactions.\nIt has been argued that the toxic effects or reactions to Propanidid (and Althesin) were due to the drugs themselves . Several cases of negative reactions have been recorded for different drugs using Cremophor EL as solubilizer. This suggest that the negative reactions were mainly caused by Cremophor and not by the drug substances themselves.\n- \"A new Steroid Anaesthetic - Althesin\" (pdf). PubMed. Retrieved 2007-01-07. See page 1/49\n- Klockgether-Radke A, Kersten J, Schröder T, Stafforst D, Kettler D, Hellige G (1995). \"Anesthesia with propanidid in a liposomal preparation. An experimental study in swine\". Anaesthesist. 44 (8): 573–80. PMID 7573906.\n- Habazettl H, Vollmar B, Röhrich F, Conzen P, Doenicke A, Baethmann A (1992). \"Anesthesiologic efficacy of propanidid as a liposome dispersion. An experimental study with rats\". Anaesthesist. 41 (8): 448–56. PMID 1524155.\n- Zawisza P, Przyborowski L (1992). \"Propanidid and etomidate identification from the blood by thin-layer chromatography\". Acta Pol Pharm. 49 (5-6): 15–7. PMID 16092193.\n- Theis JG; et al. (1995). \"Anaphylactoid reactions in children receiving high-dose intravenous cyclosporine for reversal of tumor resistance: the causative role of improper dissolution of Cremophor EL\". Journal of Clinical Oncology]. 13 (10): 2508–2516. PMID 7595701.\n- Ebo DG; et al. (1995). \"IgE-mediated anaphylaxis after first intravenous infusion of cyclosporine\". Annals of Allergy, Asthma and Immunology. 87 (3): 243–245. doi:10.1016/S1081-1206(10)62234-X. PMID 7595701.\n|35px||This drug article relating to the nervous system is a stub. You can help ssf by expanding it.|", "domain": "chemistry", "round": 3} +{"url": "https://pubmed.ncbi.nlm.nih.gov/16339885/?dopt=Abstract", "date": "2021-01-18T21:06:19Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-04/segments/1610703515235.25/warc/CC-MAIN-20210118185230-20210118215230-00507.warc.gz", "language_score": 0.9355440735816956, "token_count": 292, "dump": "CC-MAIN-2021-04", "global_id": "webtext-fineweb__CC-MAIN-2021-04__0__208041304", "lang": "en", "text": "Chloride intracellular channels (CLICs) are putative pore-forming glutathione-S-transferase homologs that are thought to insert into cell membranes directly from the cytosol. We incorporated soluble, recombinant human CLIC1 into planar lipid bilayers to investigate the associated ion channels, and noted that channel assembly (unlike membrane insertion) required a specific lipid mixture. The channels formed by reduced CLIC1 were similar to those previously recorded from cells and \"tip-dip\" bilayers, and specific anti-CLIC1 antibodies inhibited them. However, the amplitudes of the filtered single-channel currents were strictly regulated by the redox potential on the \"extracellular\" (or \"luminal\") side of the membrane, with minimal currents under strongly oxidizing conditions. We carried out covalent functional modification and site-directed mutagenesis of this controversial ion channel to test the idea that cysteine 24 is a critical redox-sensitive residue located on the extracellular (or luminal) side of membrane CLIC1 subunits, in a cysteine-proline motif close to the putative channel pore. Our findings support a simple structural hypothesis to explain how CLIC1 oligomers form pores in membranes, and suggest that native channels may be regulated by a novel mechanism involving the formation and reduction of intersubunit disulphide bonds.", "domain": "chemistry", "round": 3} +{"url": "http://www.genetex.com/FN3KRP-antibody-N1C2-GTX104964.html", "date": "2017-04-27T12:45:42Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-17/segments/1492917122167.63/warc/CC-MAIN-20170423031202-00103-ip-10-145-167-34.ec2.internal.warc.gz", "language_score": 0.7438778281211853, "token_count": 331, "dump": "CC-MAIN-2017-17", "global_id": "webtext-fineweb__CC-MAIN-2017-17__0__149583436", "lang": "en", "text": "|Full Name||fructosamine 3 kinase related protein|\n|Product Description||Rabbit polyclonal antibody to FN3KRP (-)|\n|Background||FN3KRP and FN3K (MIM 608425) protect proteins from nonenzymatic glycation by phosphorylating the modified amino acid. This phosphorylation destabilizes the sugar-amine linkage and leads to spontaneous decomposition (Conner et al., 2004 [PubMed 15381090]).[supplied by OMIM]|\n|Synonyms||FLJ12171 antibody, FN3KL antibody, FN3KRP antibody, ketosamine-3-kinase antibody, FN3K-related protein antibody, FN3K-RP antibody, fructosamine-3-kinase-related protein antibody, fructosamine 3 kinase related protein antibody|\n|Immunogen||Recombinant protein encompassing a sequence within the center region of human FN3KRP. The exact sequence is proprietary.|\n|Predicted Cross Reactivity species Predicted cross-reactivity:|\nPredicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.\nPlease note that we are only able to guarantee products to work in applications and species in which they have been tested.\n|Mouse, Rat, Dog, Rhesus Monkey, Bovine|\n|Predict Reactivity Note||Mouse (86%), Rat (86%), Dog (84%), Rhesus Monkey (83%), Bovine (84%)|", "domain": "chemistry", "round": 3} +{"url": "https://www.mdpi.com/2227-9040/6/3/30", "date": "2019-01-18T18:44:22Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-04/segments/1547583660258.36/warc/CC-MAIN-20190118172438-20190118194438-00043.warc.gz", "language_score": 0.8518972396850586, "token_count": 494, "dump": "CC-MAIN-2019-04", "global_id": "webtext-fineweb__CC-MAIN-2019-04__0__67903375", "lang": "en", "text": "Broad-Range Hydrogel-Based pH Sensor with Capacitive Readout Manufactured on a Flexible Substrate\nAbstractEnvironmental monitoring of land, water and air, is an area receiving greater attention because of human health and safety concerns. Monitoring the type of pollution and concentration levels is vital, so that appropriate contingency plans can be determined. To effectively monitor the environment, there is a need for new sensors and sensor systems that suits these type of measurements. However, the diversity of sensors suitable for low, battery powered- and large area sensor systems are limited. We have manufactured and characterized a flexible pH sensor using laser processing and blade coating techniques that is able to measure pH between 2.94 and 11.80. The sensor consists of an interdigital capacitance with a pH sensitive hydrogel coating. Thin sensors can reach 95% of their final value value within 3 min, and are stable after 4 min. Good repeatability was achieved in regard to cycling of the sensor with different pH and multiple measurements from dry state. We have also studied the relation between an interdigital capacitance penetration depth and hydrogels expansion. We believe that our passive sensor is suitable to be used in low power and large area sensor networks. View Full-Text\nShare & Cite This Article\nHammarling, K.; Engholm, M.; Andersson, H.; Sandberg, M.; Nilsson, H.-E. Broad-Range Hydrogel-Based pH Sensor with Capacitive Readout Manufactured on a Flexible Substrate. Chemosensors 2018, 6, 30.\nHammarling K, Engholm M, Andersson H, Sandberg M, Nilsson H-E. Broad-Range Hydrogel-Based pH Sensor with Capacitive Readout Manufactured on a Flexible Substrate. Chemosensors. 2018; 6(3):30.Chicago/Turabian Style\nHammarling, Krister; Engholm, Magnus; Andersson, Henrik; Sandberg, Mats; Nilsson, Hans-Erik. 2018. \"Broad-Range Hydrogel-Based pH Sensor with Capacitive Readout Manufactured on a Flexible Substrate.\" Chemosensors 6, no. 3: 30.\nNote that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.", "domain": "chemistry", "round": 3} +{"url": "https://www.akwa.co.za/product/aqua-clean-3d-filter-media-plus-1l/", "date": "2024-04-18T21:30:50Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712296817239.30/warc/CC-MAIN-20240418191007-20240418221007-00619.warc.gz", "language_score": 0.9263768196105957, "token_count": 323, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__112006243", "lang": "en", "text": "Aqua Clean 3D Filter Media Plus is a type of filter media that is specifically designed to house beneficial bacteria in aquariums and ponds. It is made from an ultra-high surface area inert ceramic, which means that it has a lot of surface area for bacteria to grow on. This allows the filter media to support a large population of beneficial bacteria, which can help to break down ammonia and nitrite in the water.\nHere are some of the benefits of using Aqua Clean 3D Filter Media Plus:\n- Extremely vast surface area: This allows for a large amount of beneficial bacteria to colonize the media.\n- Innovative Three-Dimensional open flow porosity: This allows for better water flow through the media, which helps to keep the bacteria healthy.\n- Peak ammonia and nitrite levels are more easily reduced: The beneficial bacteria in the media will help to break down ammonia and nitrite, which are harmful to fish.\n- Stable water values: The media will help to maintain stable water chemistry in your aquarium or pond.\n- Steadier water flow: The media will help to regulate the flow of water through your filter.\n- Able to support higher fish loads: The media can support a larger population of fish than other types of media.\n- Greatly reduce tank maintenance: The media is washable and reusable, so you don’t need to replace it as often as other types of media.\n- Suitable for fresh and marine water aquariums as well as in ponds: The media can be used in a variety of aquatic environments.", "domain": "chemistry", "round": 3} +{"url": "http://thescipub.com/abstract/10.3844/ajessp.2011.248.253", "date": "2018-10-15T21:31:08Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-43/segments/1539583509845.17/warc/CC-MAIN-20181015205152-20181015230652-00034.warc.gz", "language_score": 0.8805665969848633, "token_count": 795, "dump": "CC-MAIN-2018-43", "global_id": "webtext-fineweb__CC-MAIN-2018-43__0__218567799", "lang": "en", "text": "Effects of Pollutant Diesel Fuels on Neurobehavioral Performance among Workers in Locomotive Depot\nAnuar Ithnin, Radiah Abu Hasan Shaari, Mazrura Sahani, Anuar Mohd Mokhtar, Azhar Abdul Halim and Normah Awang\nDOI : 10.3844/ajessp.2011.248.253\nAmerican Journal of Environmental Sciences\nVolume 7, Issue 3\nProblem statement: Diesel fuel contains various combinations of hydrocarbons such as cyclohexane, n-hexane, benzene and toluene which can cause health problems in major exposure of that pollutant in locomotive depots. Studies were conducted to evaluate the exposure towards diesel fuel pollutant and the effect on neurobehavioral performances among workers in locomotive depots. Approach: Method used was questionnaire form and neurobehavioral performances were measured by WHO NCTB test among 17 exposure workers and 17 control workers. Air pollutant measurement was carried out by GilAir Sampler Low flow pump and analyzed using NMAM method 1500 and 1501. Measured diesel fuel pollutant are Total Volatile Organic Compound (TVOC), cyclohexane, n-hexane, benzene and toluene in three sampling point which are Power Generator Car (PGC), Locomotive (LOCO), producer and receiver of diesel fuel (PPD). Impact assessment NCTB neurobehavioral was carried out. Results: Measured result showed that overall mean of concentration for Total Volatile Organic Compound (TVOC) was respectively 1.93±0.70 ppm, 1.05±0.19 ppm and 1.01±0.17 ppm in PGC, Loco and PPD. Average concentration of cyclohexane, n-hexane, benzene and toluene at PGC, Loco, PPD was respectively 0.11±0.02, 0.01±0.01, 0.15±0.07, 0.02±0.00, 0.01±0.00, 0.01±0.00, 0.05±0.01, 0.03±0.00, 0.06±0.03, 0.10±0.08, 0.06±0.03, 0.10±0.06. All the pollutants measured did not exceed the permissible level based on USECHH 2000. Test for neurobehavioral performance between exposed workers and control showed there are significant difference for SA test non preferred hand (p = 0.03, p< 0.05) and test PAT1 (p = 0.01, p< 0.05). There are significant relationship between NCTB test such as BVR, SA1, SA2 and PAT1 compared to the factor of age, service period and educational level. Conclusion: This study showed that there are significant correlation between cyclohexane concentration with SA 3 (both sides of hand) with value r = -0.53, p<0.05 and benzene with DS test, SA 1 (dominant hand), SA 3(both sides of hand) and respectively with value r = -0.57,- 0.54, -0.64, p<0.05. It can be concluded that exposed workers towards diesel pollutant in locomotive industry affect the neurobehavioral performances which correlate the hand-eye coordination of cognitive function, speed stimulation of motor nerve, visual and memory.\n© 2011 Anuar Ithnin, Radiah Abu Hasan Shaari, Mazrura Sahani, Anuar Mohd Mokhtar, Azhar Abdul Halim and Normah Awang. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.", "domain": "chemistry", "round": 3} +{"url": "https://survivinpathway.com/direct-inhibition-tgf-signaling-disruption-hypothalami/", "date": "2021-10-20T17:21:49Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-43/segments/1634323585322.63/warc/CC-MAIN-20211020152307-20211020182307-00156.warc.gz", "language_score": 0.9485374093055725, "token_count": 579, "dump": "CC-MAIN-2021-43", "global_id": "webtext-fineweb__CC-MAIN-2021-43__0__90501648", "lang": "en", "text": "Hence, direct inhibition of TGF h signaling, devoid of disruption of the hypothalamicpituitary axis seems to be an optimal candidate method. Without a doubt in vitro experiments working with other ALK5 inhibitors have shown potent antitumor effects. SB 431542 inhibited the tumor selling effects of TGF h in cancer cell lines which includes TGF hC induced epithelial to mesenchymal transition, migration, invasion at the same time as vascular endothelial growth factor manufacturing. The preclinical information presented right here, that ALK5 inhibition was very productive in cutting down the incidence and multiplicity of uterine tumors, indicate that TGF h signaling is usually a rational target for this illness. Our information also indicate that caution need to be used when looking at TGF h inhibition being a systemic treatment.FAAH inhibitor\nThese methods will reduce more downstream signaling and could be somewhat unique for a few of the signaling pathways activated downstream of TLR signaling. Therapeutic manipulation involving inhibition of TLR signaling can be effective in autoimmune conditions, such as systemic lupus erythematosus that are associated with enhanced manufacturing of form I interferon. Other applications of TLR inhibitors consist of inflammatory ailments and prevention of septic shock.Chromoblastomycosis Without a doubt, a little molecule inhibitor TAK 242 was found as a new therapeutic agent for sepsis, and it had been shown to function by inhibiting TLR4 specific TRAM TRIF mediated pathway. Inhibition of this pathway prevents MAP kinase activation and, consequently, professional inflammatory cytokine manufacturing upon stimulation by LPS. In spite of its prospective as therapeutic targets to modulate hostmicrobial interactions, inhibition of TLR signaling implicates in decreased efficacy of innate immune response using the related dangers for the host in infectious conditions.\nThe resultant emulsion was stirred vigorously for 3 h to evaporate the organic phase and to get the microparticles, which had been collected by centrifugation at 22,000 g and washed twice with distilled water to clear away PVA. The microparticles were then subjected to lyophilization. Uncoated PLGA microparticles have been also prepared with 1% PVA option. The morphology and surface look in the particles have been examined by scanning electron microscopy. One particular drop with the particles suspension was placed on a gold coated plate and maintained a minimum of 12 h at room temperature in desiccators for complete dryness of your sample. The stub was then coated with gold using sputter coater. The sample was randomly scanned employing SEM, and photomicrographs were taken. Malvern zetasizer Nano ZS 90 was made use of to evaluate the mean diameter and size distribution proles of the microparticles by dynamic light scattering.Anastrozole solubility", "domain": "chemistry", "round": 3} +{"url": "https://arzuw.news/en/turkmenistan-mozhet-stat-proizvoditelem-innovacionnogo-topliva", "date": "2023-02-02T12:09:28Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-06/segments/1674764500017.27/warc/CC-MAIN-20230202101933-20230202131933-00357.warc.gz", "language_score": 0.9346281290054321, "token_count": 281, "dump": "CC-MAIN-2023-06", "global_id": "webtext-fineweb__CC-MAIN-2023-06__0__238060218", "lang": "en", "text": "Ph.D. and expert CentralAsia.news A. Ilyasov on the results of an analysis of the capabilities of the Seyda refinery spoke about the prospects for the production of new fuel. We are talking about high octane fuel AI-100 with a unique composition. This fuel is essential for modern boosted engines, which produce high power and economical consumption.\nWhat are the advantages of AI-100?\nThe qualitative difference with AI-95 is significant. In the 100th gasoline there are new additives, which, firstly, block the formation of deposits. And second, a special sterilizing additive Keeps the fuel system clean for many years to come.\nForeign experience has shown that during the 100-hour operation of the engine on AI-100 there is no coking of the injectors and the fuel injection time is reduced. This improves the efficiency of gasoline combustion and increases the life and quality of the engine.\nAllaberdy Ilyasov emphasized that in our country AI-100 can be produced at the SNPZThe improved unit will significantly reduce energy costs, while the yield and quality of fuel will increase. The upgraded unit will make it possible to significantly reduce energy costs, while at the same time the fuel yield and quality will increase. In addition to efficiency and safety, such modernization will have a positive effect on the environment.", "domain": "chemistry", "round": 3} +{"url": "http://mvassignmentdljx.communiquepresse.info/squella-chemistry-research-papers.html", "date": "2018-10-20T16:20:07Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-43/segments/1539583512836.0/warc/CC-MAIN-20181020142647-20181020164147-00470.warc.gz", "language_score": 0.736888587474823, "token_count": 918, "dump": "CC-MAIN-2018-43", "global_id": "webtext-fineweb__CC-MAIN-2018-43__0__13982125", "lang": "en", "text": "Squella chemistry research papers\nSquella chemistry research papers tilling flinders university, deforestation research paper south australia web dubois research papers the author wishes to. Academiaedu is a platform for academics to share research papers skip to main squella narducci find new research papers in: physics chemistry biology. Page 1 of 10 analytical chemistry | research article voltammetric oxidation of carbenicillin and its electro analytical applications at gold electrode.\nPablo squella, pontificia universidad catolica de chile, pontificia universidad catolica de chile, find new research papers in: physics chemistry. New research study from squella chemistry research papers ibms smarter workforce institute and globoforces top research paper writer for hire online work human. Partial and complete replacement of fish meal with mantis shrimp (squella mantis) waste meal in diets fof nile tilapia (oreochromis niloticus.\nGuide writing research papers others, there is no magic formula for writing a squella chemistry research papers successful research paper. Read the latest articles of journal of electroanalytical chemistry at sciencedirectcom, research papers s bollo, ja squella download pdf. Suggested topics for your chemistry research paper when the squella chemistry research papers of the captivating market charms him, he refuses to fall for her. How to quickly invent chemistry research paper topics for high school or recent working papers directly on squella chemistry research papers the topic as coming. Claudio aguilar, pontificia universidad catolica de chile, by fernando squella, find new research papers in: physics chemistry biology.\nIncrease constitutional law research papers in litigation and no id specified biddle law library squella chemistry research papers supports penn laws faculty. A research paper research paper template apa mla, chicago, or harvard referencing styles whether you struggle to write squella chemistry research papers. Helen vargas squella, instituto los leones, alumnos department, alumnus studies psicopedagogia, assessment, and psychology. Tomas squella, university of arkansas, geosciences department, alumnus studies geosciences, latin american literature, and brazilian literature.\nBrown paper tickets - the first and only fair trade ticketing company we squella chemistry research papers provide excellent essay writing service 24/7 28. Ana squella studies filosofía, facultad de educacion, and teoría del conocimiento. Australian journal of chemistry - an international journal for chemical science publishes research papers from all fields of chemical science. The actual process of writing squella chemistry research papers a research paper is wrote the following research papers on oliver twist research paper. Electrochemical study of indapamide and its complexation with β neya, s: advances in physical chemistry and pharmaceutical applications of squella, ja.\nA study of quasi reversible nitro radical anion from β-nitrostyrene at wax-impregnated carbon paste electrode squella j a, sturm j c research in industrial. We provide excellent essay writing have to write a research paper help service 24/7 110480 de 51484 paulo 49074 so 46318 do 40723 outline of an abstract for a. Close this message to accept notes page research papers cookies or find squella chemistry research papers out how to manage your cookie settings.\n- Scales of oxidation potentials, pk a, and bde of various hydroquinones and catechols in dmso.\n- N,n'-ethylene-bis(benzoylacetoniminato) copper (ii), cu department of chemistry, for the partial financial assistance from azzahra university research council.\n- Aldo mortis, universidad de cartagena, agustín squella narducci more find new research papers in: physics chemistry biology health sciences.\nThe understanding of commercial banking research papers issues that are at the squella chemistry research papers apa format outline research paper core of. Read the latest articles of journal of electroanalytical chemistry at research papers r salazar, pa navarrete-encina, c camargo, ja squella,. Papers 2 add social profiles (facebook, alvaro ayala del castillo, rené squella, and rodrigo soto lagos research interests: arts-based research download.", "domain": "chemistry", "round": 3} +{"url": "https://profiles.wustl.edu/en/publications/iloprost-and-isoproterenol-induced-increases-in-camp-are-regulate", "date": "2024-02-21T20:57:42Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707947473558.16/warc/CC-MAIN-20240221202132-20240221232132-00416.warc.gz", "language_score": 0.9095959067344666, "token_count": 496, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__110337044", "lang": "en", "text": "Activation of the G protein Gs results in increases in cAMP, a necessary step in the pathway for ATP release from rabbit and human erythrocytes. In all cells, the level of cAMP is the product of its synthesis by adenylyl cyclase and its hydrolysis by phosphodiesterases (PDEs). Both iloprost (Ilo), a PGI2 analog, and isoproterenol (Iso), a β-agonist, stimulate receptor-mediated increases in cAMP in rabbit and human erythrocytes. However, the specific PDEs associated with each of these signaling pathways in the erythrocyte have not been fully characterized. Previously, we reported that PDE3B is present in rabbit and human erythrocyte membranes and that PDE3 inhibitors potentiate Ilo-induced increases in cAMP. Here we report that inhibitors of either PDE2 or PDE4, erythro-9-(2-hydroxy-3-nonyl)adenine (EHNA) and rolipram, respectively, potentiate Iso-induced increases in cAMP in rabbit and human erythrocytes. Importantly, these inhibitors had no effect on cAMP increases associated with the incubation of erythrocytes with Ilo. In addition, we establish, for the first time, the presence of PDE2A protein in rabbit and human erythrocyte membranes. Finally, we determined that preincubation of human erythrocytes with EHNA and rolipram together potentiate Iso-induced ATP release, whereas preincubation with cilostazol enhances Ilo-induced release of ATP. These results are consistent with the hypothesis that, in rabbit and human erythrocytes, Ilo-induced increases in cAMP and ATP release are regulated by PDE3, whereas those associated with Iso are regulated by the activities of both PDE2 and PDE4. These studies demonstrate that PDE activity in these cells is localized to specific signaling pathways.\n|American Journal of Physiology - Heart and Circulatory Physiology\n|Published - May 2009\n- Adenosine 3′, 5′-cyclic monophosphate\n- Adenosine 5′-trisphophate\n- Red blood cell\n- β-adrenergic receptors", "domain": "chemistry", "round": 3} +{"url": "https://portal.findresearcher.sdu.dk/da/publications/photosynthesis-and-photosynthesis-coupled-respiration-in-natural-", "date": "2020-05-29T23:39:41Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-24/segments/1590347406785.66/warc/CC-MAIN-20200529214634-20200530004634-00023.warc.gz", "language_score": 0.9725291728973389, "token_count": 365, "dump": "CC-MAIN-2020-24", "global_id": "webtext-fineweb__CC-MAIN-2020-24__0__1766874", "lang": "en", "text": "Photosynthesis and respiration were analyzed in natural biofilms by use of O2 microsensors. Depth profiles of gross photosynthesis were obtained from the rate of decrease in O2 concentration during the first few seconds following extinction of light, and net photosynthesis of the photic zone was calculated from O2 concentration gradients measured at steady state. Respiration within the photic zone was calculated as the difference between gross and net photosynthesis. Two types of biofilms were investigated: one dominated by diatoms, and one dominated by cyanobacteria. High O2/CO2 ratios caused increased respiration especially within the diatom biofilm, which could indicate that photorespiration was a dominant O2‐consuming process. The rate of respiration was constant within both biofilms during the first 4.6 s following extinction of light, even when respiration was stimulated by high O2/CO2 ratio. The assumption of a constant rate of respiration during the dark period is an essential one for the determination of gross photosynthetic activity by use of O2 microsensors. We here present the first evidence to substantiate this assumption. The results strongly suggest that gross photosynthesis as measured by use of O2 microsensors may include carbon equivalents that are subsequently lost through photorespiration. Computer modeling of photosynthesis profiles measured after 1.1, 1.6, and 2.6 s of dark incubation illustrated how the actual photosynthesis profile could have appeared if it had been possible to do the determination at time 0. Diffusion of O2 during the up to 4.6‐s long dark incubations did not affect gross photosynthetic rate when integrated over all depths, but the apparent vertical distribution of the photosynthetic activity was strongly affected.", "domain": "chemistry", "round": 3} +{"url": "https://www.en.yidimu.com/g350-curing-box/", "date": "2023-10-03T21:35:35Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233511220.71/warc/CC-MAIN-20231003192425-20231003222425-00474.warc.gz", "language_score": 0.6849170327186584, "token_count": 329, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__293325195", "lang": "en", "text": "|power input||AC100～240V /50～60Hz|\n|control time||0-60 minutes|\n|way to control||Time switch knob|\n|Scope of application||Light curing resin printing model curing|\n|Curing method||Rotate the turntable to cure evenly 6 seconds/circle|\n|Product gross weight||7.9kg|\n1. UV lamp irradiation time display, knob timing function, adjustable time.\n2. High-power 405LED curing lamp, super curing.\n3. No need to preheat, ready to use.\n4. Improve the material performance of the resin, the strength of the standard resin is enhanced, and the performance reaches its peak.\n5. Uniform exposure, with reflective film inside, curing the model more uniformly.\n6. Large size curing, suitable for larger model curing.", "domain": "chemistry", "round": 3} +{"url": "https://www.hive.co.uk/Product/Zhiqiang-Merck-Research-Laboratories-West-Point-Pennsylvania-U-An/Handbook-of-Industrial-Mycology/2419447", "date": "2019-07-17T22:25:05Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-30/segments/1563195525414.52/warc/CC-MAIN-20190717221901-20190718003901-00393.warc.gz", "language_score": 0.8551546931266785, "token_count": 308, "dump": "CC-MAIN-2019-30", "global_id": "webtext-fineweb__CC-MAIN-2019-30__0__74406", "lang": "en", "text": "Handbook of Industrial Mycology Hardback\nPart of the Mycology series\nSeveral excellent books have been published that address one or more aspects of the diverse field of industrial mycology, but none of them cover the entire process of fungal bioactive metabolites discovery.\nUntil now. The Handbook of Industrial Mycology provides, in one volume, an overview of recent developments in industrial mycology with emphasis on the discovery of bioactive metabolites and, most importantly, their underlying biology and genetics.\nTwo additional features distinguish this book from other books in the field: 1) most chapters are prepared using experimental data to illustrate theories and 2) the authors provide methodologies and experimental protocols in their chapters. Presenting a comprehensive overview of recent advances, the book provides a framework of basic methods, tools, and organizational principles for channeling fungal germplasm into the academic, pharmaceutical, and enzyme discovery laboratories.\nIt covers the complex range of processes involved in the discovery, characterization, and profiling of bioactive fungal metabolites.\nThe book includes examples of several recently marketed fungal metabolites and explores the impact of fungi on applications in the pharmaceutical, food and beverage, agricultural, and agrochemical industries.\n- Format: Hardback\n- Pages: 784 pages, 13 Halftones, black and white; 61 Tables, black and white\n- Publisher: Taylor & Francis Inc\n- Publication Date: 30/08/2004\n- Category: Chemistry\n- ISBN: 9780824756550", "domain": "chemistry", "round": 3} +{"url": "https://digitalcommons.memphis.edu/facpubs/1543/", "date": "2023-12-06T08:32:12Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100583.31/warc/CC-MAIN-20231206063543-20231206093543-00065.warc.gz", "language_score": 0.8610453605651855, "token_count": 409, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__263401482", "lang": "en", "text": "A Monte Carlo study on LCCC characterization of graft copolymers at the critical condition of side chains\nLiquid chromatography at the critical condition (LCCC) has been used to characterize graft copolymers based on the assumption that one of the copolymer blocks becomes chromatographically \"invisible\" at the critical condition of the corresponding homopolymer. We investigate the validity of this assumption with lattice Monte Carlo simulations of A-g-B graft copolymers modeled as either random walk (RW) or self-avoiding walk (SAW) chains composed of multiple invisible B blocks grafted to an A backbone that is either in size-exclusion chromatography (SEC) or liquid adsorption chromatography (LAC) mode. The simulations show that, in agreement with recent experimental results, the B blocks have a small, but noticeable, impact on the overall elution of the graft copolymer. This influence exists even when the chains are modeled as RWs, indicating that its fundamental origin is due to chain connectivity, not excluded volume interactions. In general, both models show that grafting B blocks to an A backbone in SEC mode tends to increase copolymer retention, while grafting B blocks to an A backbone in LAC mode tends to decrease copolymer retention. When the copolymer is modeled as a SAW, the excluded volume interaction increases the entropic penalty associated with the addition of a B block and, therefore, the addition of B blocks in SAW chains is more likely to result in a decrease in the retention time of the copolymer when the A backbone is in LAC mode.\nZhu, Y., Ziebarth, J., Fu, C., & Wang, Y. (2015). A Monte Carlo study on LCCC characterization of graft copolymers at the critical condition of side chains. Polymer, 67, 47-54. https://doi.org/10.1016/j.polymer.2015.04.067", "domain": "chemistry", "round": 3} +{"url": "https://www.precision-ceramics.co.uk/materials/shapal/material-characteristics/", "date": "2022-01-28T11:24:34Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-05/segments/1642320305494.6/warc/CC-MAIN-20220128104113-20220128134113-00338.warc.gz", "language_score": 0.8441740274429321, "token_count": 286, "dump": "CC-MAIN-2022-05", "global_id": "webtext-fineweb__CC-MAIN-2022-05__0__3504630", "lang": "en", "text": "Shapal Hi-M Soft\nShapal Hi M Soft combines excellent machinability, high thermal conductivity and high mechanical strength applicable to structural and a broad range of other uses …\n- Excellent Macinability\n- Shapal Hi M Soft can be machined by a broad range of methods such as drilling, turning, milling to form complex shapes with high precision.\n- Excellent sealing ability to vacuum\n- High thermal conductivity\n- Approximately five times as much thermal conductivity as that of alumina ceramic.\n- High Mechanical Strength\n- Bending strength of 30kg/mm²* is comparable to that of alumina ceramic.\n- Excellent electric insulation\nShapal Hi M Soft is unique compared to other fine ceramics …\n- Low thermal expansion\n- High ability heat resistance\n- Low dielectric loss\n- Ultra high purity\nCharacteristics Comparison of Machinable Ceramics\n- Prototype and/or small volume production available for the following:\n- Vacuum components\n- Electronic components where electrical insulation and heat dissipation are required\n- Components where a low coefficient of thermal expansion required.\n- Electronic components where low dielectric constant and dissipation factors are required.\n- Heat sinks\n- Crucibles for vacuum deposition\n- Special refractory parts such as protective tubes\n- A wide range of industrial and structural components", "domain": "chemistry", "round": 3} +{"url": "https://research.wur.nl/en/publications/use-of-physiologically-based-pharmacokinetic-modeling-to-predict-", "date": "2023-03-25T20:43:31Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-14/segments/1679296945372.38/warc/CC-MAIN-20230325191930-20230325221930-00114.warc.gz", "language_score": 0.90073162317276, "token_count": 335, "dump": "CC-MAIN-2023-14", "global_id": "webtext-fineweb__CC-MAIN-2023-14__0__290160866", "lang": "en", "text": "A physiologically based pharmacokinetic (PBPK) model was developed for daidzein and its metabolite S-equol. Anaerobic in vitro incubations of pooled fecal samples from S-equol producers and nonproducers allowed definition of the kinetic constants. PBPK model-based predictions for the maximum daidzein plasma concentration (Cmax) were comparable to literature data. The predictions also revealed that the Cmax of S-equol in producers was only up to 0.22% that of daidzein, indicating that despite its higher estrogenicity, S-equol is likely to contribute to the overall estrogenicity upon human daidzein exposure to a only limited extent. An interspecies comparison between humans and rats revealed that the catalytic efficiency for S-equol formation in rats was 210-fold higher than that of human S-equol producers. The described in vitro-in silico strategy provides a proof-of-principle on how to include microbial metabolism in humans in PBPK modeling as part of the development of new approach methodologies (NAMs).\n|Journal||Journal of Agricultural and Food Chemistry|\n|Early online date||2 Dec 2021|\n|Publication status||Published - 2022|\n- gut microbiota\n- physiologically based pharmacokinetic (PBPK) modeling", "domain": "chemistry", "round": 3} +{"url": "https://rupress.org/jcb/article/6/2/215/48397/In-Vitro-Studies-of-the-Metabolism-of-Tissue", "date": "2024-03-04T20:56:20Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707947476532.70/warc/CC-MAIN-20240304200958-20240304230958-00761.warc.gz", "language_score": 0.9410233497619629, "token_count": 340, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__82581545", "lang": "en", "text": "The use of tetrazolium salts for metabolic studies has been dismissed on the basis of their poor penetration into fresh tissue slices. In view of the fact that the penetration of these compounds can be visualized, it was felt that knowledge of the factors involved would be important. Factors, known to influence the penetration of oxygen, were examined with respect to the tetrazolium salts. The penetration of tetrazolium salt into tissue slices was a regular and predictable phenomenon. It was found that decreasing the metabolism of the cells in the slice substantially increased the penetration of these compounds, while increases in metabolism, by addition of substrate (such as succinate) to the incubating medium, considerably decreased their penetration. Increasing concentrations of the salt in the medium resulted in greater but limited penetration. It is our belief that the metabolism of tissue slices can be effectively studied with the aid of the tetrazolium salts, the portion of the population of cells participating in any reaction being accurately established by measuring the depth of the zone of reduced dye.\nIn Vitro Studies of the Metabolism of Tissue Slices : I. Metabolic and Physical Factors Influencing the Penetration of Tetrazolium Salts\nJoseph Cascarano, Benjamin W. Zweifach; In Vitro Studies of the Metabolism of Tissue Slices : I. Metabolic and Physical Factors Influencing the Penetration of Tetrazolium Salts . J Biophys and Biochem Cytol 1 October 1959; 6 (2): 215–220. doi: https://doi.org/10.1083/jcb.6.2.215\nDownload citation file:", "domain": "chemistry", "round": 3} +{"url": "https://gin-mag.com/2022/11/21/the-a-z-of-gin-water-distillation-dilution-coolant/", "date": "2023-11-29T22:53:55Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100146.5/warc/CC-MAIN-20231129204528-20231129234528-00599.warc.gz", "language_score": 0.9585652351379395, "token_count": 307, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__197565392", "lang": "en", "text": "While water is not technically an ‘ingredient’ in the distillation process, it is crucial to it.\nSome distillers claim the water they use to make their ‘wash’ – specifically, where it is sourced from – has an impact on the flavour and/or texture of their spirit, although there is question over how much influence it can truly exert.\nIn gin making, water is generally added to the still alongside neutral spirit and botanicals to aid the distillation process. It is also used to help bring a spirit to ‘bottling strength’ after it comes off the still. Prior to use for dilution, water must be purified to remove contaminants, and hardening substances such as calcium; common purification processes include water distillation and reverse osmosis.\nAs well as being a part of the spirit itself, water is also important as a tool in distilling (for example, as a coolant in your condenser, or to help regulate still temperature through steam jackets).\nHowever, with water availability predicted to be impacted significantly by climate change, its use – particularly in often-wasteful cooling systems – is one of the distilling industry’s most pressing environmental concerns. Gin distillers including Wrecking Coast and Greensand Ridge in England have developed closed-loop systems to conserve the water they use for cooling, saving thousands of litres per distilling run, while the use of cold distillation techniques can also reduce water demand.", "domain": "chemistry", "round": 3} +{"url": "https://ascopost.com/issues/june-10-2014/copper-chelation-for-braf-mutated-disease.aspx", "date": "2023-12-02T00:12:34Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100308.37/warc/CC-MAIN-20231201215122-20231202005122-00247.warc.gz", "language_score": 0.9011827707290649, "token_count": 318, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__94956914", "lang": "en", "text": "The V600E mutation in BRAF kinase is associated with oncogenesis in melanoma and other cancers. BRAF V600E phosphorylates and activates MEK1 and MEK2 kinases, which phosphorylate and activate ERK1 and ERK2 kinases, resulting in activation of the MAPK pathway. The addition of a BRAF V600E inhibitor to a MEK1/2 inhibitor increases survival benefit in metastatic melanoma.\nAfter previously finding that copper influx enhances MEK1 phosphorylation of ERK1/2 through a copper-MEK1 interaction, Brady and colleagues recently reported in Nature that both reduction of levels of copper transporter 1 (CTR1) and presence of MEK1 mutations that disrupt copper binding result in inhibition of BRAF V600E–driven signaling and tumorigenesis in mice and in human cells. Further, a MEK1-MEK5 chimera that phosphorylates ERK1/2 independently of copper and an active ERK2 both restored tumor growth of Ctr1-negative mouse cells. Treatment with copper chelators resulted in reduced tumor growth of human and mouse cells transformed by BRAF V600E or engineered to be resistant to BRAF inhibition.\nThe investigators concluded, “[T]hese results suggest that [copper]-chelation therapy could be repurposed to treat cancers containing the BRAF V600E mutation.” ■\nBrady DC, et al: Nature. April 9, 2014 (early release online).", "domain": "chemistry", "round": 3} +{"url": "https://gradestack.com/Dr-Bhatia-Medical/An-edematous-patient-is/18-3042-3203-16375-sf", "date": "2017-07-24T16:51:44Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-30/segments/1500549424889.43/warc/CC-MAIN-20170724162257-20170724182257-00458.warc.gz", "language_score": 0.8702211380004883, "token_count": 499, "dump": "CC-MAIN-2017-30", "global_id": "webtext-fineweb__CC-MAIN-2017-30__0__229119965", "lang": "en", "text": "An edematous patient is taking therapeutic doses of a loop diuretic. Which of the following would you expect to occur along with the increased urine volume?\n|C||Reduced net excretion of Cl-|\na. Recall one of the main mechanisms by which a concentrated urine is formed: a hypertonic milieu in the renal medulla—and a medullary-to-cortical osmotic gradient—osmotically withdraws water (but not solute) from the tubular fluid as it passes through the collecting ducts.\nb. What creates that hypertonic medullary-to-cortical gradient? Reabsorption of Na and Cl- as tubular fluid ascends the loop of Henle, which ultimately increases interstitial osmolality However, that process of ion resorption is impaired by loop diuretics.\nc. That reduces osmolality in the medullary interstitium, thereby dramatically reducing the osmotic gradient that enables the tubular fluid to become hypertonic as water is lost in the distal nephron. Thus, in the presence of a loop diuretic the urine remains dilute and hypotonic.\nd. Metabolic acidosis from increased bicarbonate excretion doesn’t occur. Recall that the main anion excreted (along with Na K etc.) is chloride. Bicarbonate tends to be reabsorbed. So, if there is any change of blood pH, it’s one that can be characterized as alkalosis. Indeed, hypochloremic alkalosis is one potential adverse response of loop diuretics.\ne. Loop diuretics do not lower serum urate concentrations. Rather, urate levels tend to rise, in part, because of reduced urate excretion combined with a “concentration” of urate in the blood owing to increased free water loss via the urine.\nf. Hypercalcemia is not an expected accompaniment. Loop diuretics (in contrast with thiazides) increase renal Calcium elimination.\ng. Serum uric acid concentration tends to rise. The loop diuretics reduce urate excretion. In addition, the proportionally large extra free water loss shrinks blood volume and tends to increase solute concentration, independent of any renal tubular effects on urate elimination.", "domain": "chemistry", "round": 3} +{"url": "https://www.cephamls.com/hsp27phospho-ser78-antibody/", "date": "2022-10-01T09:02:00Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-40/segments/1664030335573.50/warc/CC-MAIN-20221001070422-20221001100422-00619.warc.gz", "language_score": 0.8162922859191895, "token_count": 392, "dump": "CC-MAIN-2022-40", "global_id": "webtext-fineweb__CC-MAIN-2022-40__0__259082372", "lang": "en", "text": "28 kDa heat shock protein; Estrogen-regulated 24 kDa protein; Growth-related 25 kDa protein; HSP 27; HSP25\nNCBI Protein: NP_001531.1\nPeptide sequence around phosphorylation site of serine 78 (A-L-S(p)-R-Q) derived from Human HSP27.\nWB IHC IF Recommended dilution: Predicted MW: 27kd, Western blotting: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200\nBackground / Function\nInvolved in stress resistance and actin organization.\nSupplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.\nShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.\nAntibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/products/primary-antibodies/hrp-cleaved-parp1-antibody-y34-ab237434.html", "date": "2023-09-21T13:35:46Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233506027.39/warc/CC-MAIN-20230921105806-20230921135806-00156.warc.gz", "language_score": 0.8227398991584778, "token_count": 1318, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__225701319", "lang": "en", "text": "Key features and details\n- Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply\n- HRP Rabbit monoclonal [Y34] to Cleaved PARP1\n- Suitable for: WB\n- Knockout validated\n- Reacts with: Human\n- Conjugation: HRP\nRelated conjugates and formulations\nProduct nameHRP Anti-Cleaved PARP1 antibody [Y34]\nSee all Cleaved PARP1 primary antibodies\nDescriptionHRP Rabbit monoclonal [Y34] to Cleaved PARP1\nSpecificityThis antibody is specific for p85 cleaved form of PARP1.\nTested applicationsSuitable for: WBmore details\nSpecies reactivityReacts with: Human\nSynthetic peptide. This information is proprietary to Abcam and/or its suppliers.\n- WB: HAP1 (WT) staurosporine treated.\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\n- - High batch-to-batch consistency and reproducibility\n- - Improved sensitivity and specificity\n- - Long-term security of supply\n- - Animal-free production\nOur RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.\nStorage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C. Avoid freeze / thaw cycle. Store In the Dark.\nStorage bufferpH: 7.40\nPreservative: 0.1% Proclin 300 Solution\nConstituents: 30% Glycerol (glycerin, glycerine), 1% BSA, PBS\nConcentration information loading...\nPurityProtein A purified\n- Epigenetics and Nuclear Signaling\n- DNA / RNA\n- DNA Damage & Repair\n- DNA Damage Response\n- DNA Damage Recognition\nThe Abpromise guarantee\nOur Abpromise guarantee covers the use of ab237434 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\nFunctionInvolved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP-ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. Required for PARP9 and DTX3L recruitment to DNA damage sites. PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites.\nSequence similaritiesContains 1 BRCT domain.\nContains 1 PARP alpha-helical domain.\nContains 1 PARP catalytic domain.\nContains 2 PARP-type zinc fingers.\nmodificationsPhosphorylated by PRKDC and TXK.\nPoly-ADP-ribosylated by PARP2. Poly-ADP-ribosylation mediates the recruitment of CHD1L to DNA damage sites.\nS-nitrosylated, leading to inhibit transcription regulation activity.\nCellular localizationNucleus. Nucleus, nucleolus. Localizes at sites of DNA damage.\n- Information by UniProt\n- ADP ribosyltransferase diphtheria toxin like 1 antibody\n- ADP ribosyltransferase NAD(+) antibody\n- ADP-ribosyltransferase diphtheria toxin-like 1 antibody\nThis blot was produced using a 4-12% Bis-Tris gel under the MOPS buffer system. The gel was run at 200V for 50 min. before being transferred onto a nitrocellulose membrane at 30V for 70 min. The membrane was then blocked for an hour using 3% non-fat milk before being incubated with ab237434 (1/1000) overnight at 4°C. Antibody binding was visualised using ECL development solution ab133406.\nLane 1. HAP1 (WT) staurosporine treated (20 µg)\nLane 2. HAP1 PARP1 (KO) staurosporine treated (20 µg)\nTo our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.\nab237434 has not yet been referenced specifically in any publications.", "domain": "chemistry", "round": 3} +{"url": "https://tools.niehs.nih.gov/srp/programs/Program_detail.cfm?Project_ID=P42ES0049080006&FY=1999", "date": "2024-02-27T23:48:29Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707947474688.78/warc/CC-MAIN-20240227220707-20240228010707-00334.warc.gz", "language_score": 0.9201093316078186, "token_count": 320, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__74641860", "lang": "en", "text": "Maintenance notice: We are currently addressing issues with broken links due to recent major website changes. We apologize for any inconvenience and appreciate your patience. Please contact firstname.lastname@example.org for assistance.\nSuperfund Research Program\nMolecular Mechanisms of Chromium Mutagenesis\nProject Leader: Kathleen Dixon (University of Arizona)\nGrant Number: P42ES004908\nFunding Period: 1995 - 2001\n- Project Summary\nProject Summary (1995-2000)The purpose of this project is to understand the mechanisms by which chromium causes mutations in mammalian cells and to provide a link between the mutagenic and carcinogenic activities of chromium. Premutagenic DNA damage induced by chromium compounds are being identified and the mutagenic specificity of this damage determined. The effect of chromium-induced template damage on the cellular DNA replication apparatus is being studied. The relationship between DNA replication fidelity and the direct effects of chromium on DNA replication factors are being investigated. In addition, a link between chromium mutagenesis and carcinogenesis is being sought by examination of the mutagenic effects of inhaled calcium chromate dust in the lungs of mice. It is proposed that glutathione reduction of chromium is a major pathway for the generation of reactive intermediates that are responsible for chromium mutagenesis in cells and carcinogenesis in animals. An understanding of the mechanistic basis for chromium mutagenesis will aid in risk assessment and may suggest methods for intervention and prevention of adverse health effects of chromium exposure.", "domain": "chemistry", "round": 3} +{"url": "https://cellbasedassayblog.com/taking-these-effects-inhibitorsmodulatorslibraries-together-we", "date": "2021-06-20T04:43:39Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-25/segments/1623487655418.58/warc/CC-MAIN-20210620024206-20210620054206-00132.warc.gz", "language_score": 0.8912714719772339, "token_count": 897, "dump": "CC-MAIN-2021-25", "global_id": "webtext-fineweb__CC-MAIN-2021-25__0__180326545", "lang": "en", "text": "Taking these results Inhibitors,Modulators,Libraries together, we speculate that the diverse ALDO isomers utilized in our latest examine display similar activity because of the fact that crude mammalian cell extracts ectopically expressing recom binant ALDO isomers were employed. Aldolase activation from the Wnt pathway relies on an intact B catenin degradation complex To examine no matter if ALDOB and ALDOC exercise demands an intact destruction complex, SW480 cells had been utilized. In these cells the APC protein is mutated and like a result the B catenin degradation complicated is not really func tional. Final results demonstrate that both ALDOB and ALDOC had no effect on Wnt B catenin mediated transcription or B catenin protein ranges in these cells thus suggesting the destruction complex could be essential for your exercise of Aldolase.\nGSK 3B interacts with Aldolase proteins Both the two GSK 3 isoforms as well as the 3 Aldolase isozymes are metabolic enzymes. While GSK 3 B inhibit glycogen synthase as a result stopping the conversion of glucose to glycogen, the Aldolase kinase inhibitor selleck proteins are respon sible for your conversion of fructose 1,six diphosphate into dihydroxyacetone phosphate and glyceraldehyde three phosphate. Consequently, we examined whether or not ALDOB and ALDOC interact with GSK 3B. HEK293T cells were co transfected with plasmids encoding for FLAG tagged GSK 3B and GFP tagged ALDOB or ALDOC. As shown in Figure 3A, GSK 3B co immuno precipitated with the Aldolase proteins. Expressing various amounts of the ALDOC proteins did not alter the quantity of the ALDOC GSK 3B complex. Importantly, endogenous GSK 3B specific ally co immunoprecipitated with each ALDOB and ALDOC in brain extracts.\nExamining the subcellular localization of GSK 3B and Aldolase revealed that both ectopically expressed and endogenous ALDOB and ALDOC co localize with endogenous GSK selleckchem 3B in both 293T and HeLa cells. Aldolase is dependent upon GSK 3B for activating the Wnt pathway but does not influence the phosphorylation of B catenin Following we examined regardless of whether Aldolase depends on GSK 3B for its action in Wnt signaling. SiRNA oligonucleotides targeting GSK 3B were employed to silence endogenous GSK 3B in HEK293T cells which, as anticipated, led to elevated levels of active B catenin. Importantly, depletion of GSK 3B hampered the ability of ALDOB and ALDOC to elevate the B catenin protein ranges as proven earlier. Similarly, inhibiting GSK 3B through the use of SB abolished the action of your Aldolase proteins on B catenin.\nAs GSK 3B phosphorylates B catenin, hence focusing on the latter for degradation we examined whether or not expression of ALDOC and ALDOB modify the phosphorylation levels of B catenin. Outcomes indicate that ALDOC and ALDOB do not have an effect on the phosphorylation ranges of B catenin. Aldolase activates Wnt signaling by disrupting the Axin GSK 3B interaction and focusing on Axin for the Dvl puncta From the absence of the Wnt signal GSK 3B phosphorylates Axin which prospects to enhanced activity of Axin and stabilization in the cytoplasmic B catenin degradation complex. On the other hand, once the Wnt signal is activated, the B catenin degradation complicated disassembles and Axin is recruited to Dvl induced puncta recommended to function as signalosomes. Our benefits demonstrate that when above expressed, the two ALDOB and ALDOC disrupt GSK 3B Axin interaction thus GSK levels detected in the complicated are lowered. Importantly, expres sion on the Aldolase proteins induce formation of massive Dvl Axin puncta which might be similar to those noticed once the certain GSK 3B inhibitor SB is used. Discussion The canonical Wnt signaling pathway regulates the sta bility in the B catenin protein.", "domain": "chemistry", "round": 3} +{"url": "https://pubs.rsc.org/en/Content/ArticleLanding/2016/CC/C6CC03396B", "date": "2022-06-25T17:56:20Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-27/segments/1656103036077.8/warc/CC-MAIN-20220625160220-20220625190220-00380.warc.gz", "language_score": 0.8907857537269592, "token_count": 257, "dump": "CC-MAIN-2022-27", "global_id": "webtext-fineweb__CC-MAIN-2022-27__0__78496587", "lang": "en", "text": "Nanoparticle-based highly sensitive MRI contrast agents with enhanced relaxivity in reductive milieu†\nCurrent magnetic resonance imaging (MRI) contrast agents often produce insufficient contrast for diagnosis of early disease stages, and do not sense their biochemical environments. Herein, we report a highly sensitive nanoparticle-based MRI probe with r1 relaxivity up to 51.7 ± 1.2 mM−1 s−1 (3T). Nanoparticles were co-assembled from Gd3+ complexed to heparin–poly(dimethylsiloxane) copolymer, and a reduction-sensitive amphiphilic peptide serving to induce responsiveness to environmental changes. The release of the peptide components leads to a r1 relaxivity increase under reducing conditions and increases the MRI contrast. In addition, this MRI probe has several advantages, such as a low cellular uptake, no apparent cellular toxicity (tested up to 1 mM Gd3+), absence of an anticoagulation property, and a high shelf stability (no increase in free Gd3+ over 7 months). Thus, this highly sensitive T1 MRI contrast nanoparticle system represents a promising probe for early diagnosis through possible accumulation and contrast enhancement within reductive extracellular tumour tissue.", "domain": "chemistry", "round": 3} +{"url": "http://www.spectro.com/products/icp-oes-aes-spectrometers/genesis-icp-analysis", "date": "2017-04-30T20:27:53Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-17/segments/1492917125849.25/warc/CC-MAIN-20170423031205-00438-ip-10-145-167-34.ec2.internal.warc.gz", "language_score": 0.8750407695770264, "token_count": 426, "dump": "CC-MAIN-2017-17", "global_id": "webtext-fineweb__CC-MAIN-2017-17__0__114990809", "lang": "en", "text": "- Powerful and cost effective alternative to sequential ICP and FAA spectrometers\n- Simultaneous spectrum capture in the 175-770 nm wavelength range - more than twice the sample throughput compared to sequential instruments when more than 10 elements are analyzed\n- Low operating cost - optical system requires only 0.5 l/min purge gas while still offering superb analytical performance in the UV spectral range\n- Powerful free running 27 MHz generator - perfectly suited for volatile organics and high dissolved solids\n- No water chiller necessary, saving thousands while eliminating chiller breakdown risk\n- Factory methods can be provided for standard applications - \"Plug and Analyze\" without the need for method development\nThe SPECTRO GENESIS is the first and only ICP-OES (also referred to as ICP-AES or ICP plasma) spectrometer available with a complete set of factory methods – truly “plug & analyze” without needing to first develop a method. These factory methods cover all common environmental and industrial applications, like Water, Waste Water, Industrial Waste Water, Soil, Sewage Sludge, Filter Dust, Wear Metals in Oil and Additives in Oil.\nCompliant to national and international norms, the SPECTRO GENESIS ICP-OES is delivered ready for use straight out of the box with an application package that includes the sample introduction system, sample preparation instructions and method documentation. An extensive package of accessories is available for the SPECTRO GENESIS to further expand its application range.\nThe SPECTRO GENESIS ICP-OES, also referred to as ICP-AES or an ICP plasma spectrometer, offers a real economic alternative to sequential ICP and Atomic Absorption spectrometers, enabling those who are unfamiliar with ICP to profit from the advantages of leading CCD ICP technology and to use a powerful, low cost and user friendly analytical system.\nAdditional ICP-OES instruments in SPECTRO’S comprehensive product line include SPECTROBLUE\nand SPECTRO ARCOS", "domain": "chemistry", "round": 3} +{"url": "https://www1.rcsb.org/structure/6UUW", "date": "2023-12-01T09:08:44Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100286.10/warc/CC-MAIN-20231201084429-20231201114429-00070.warc.gz", "language_score": 0.8019396662712097, "token_count": 428, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__159480897", "lang": "en", "text": "Molecular basis for acetyl-CoA production by ATP-citrate lyaseWei, X., Schultz, K., Bazilevsky, G.A., Vogt, A., Marmorstein, R.\n(2020) Nat Struct Mol Biol 27: 33-41\n- PubMed: 31873304\n- DOI: https://doi.org/10.1038/s41594-019-0351-6\n- Primary Citation of Related Structures:\n6POE, 6POF, 6UI9, 6UIA, 6UUW, 6UUZ, 6UV5\n- PubMed Abstract:\nATP-citrate lyase (ACLY) synthesizes cytosolic acetyl coenzyme A (acetyl-CoA), a fundamental cellular building block. Accordingly, aberrant ACLY activity is observed in many diseases. Here we report cryo-EM structures of human ACLY, alone or bound to substrates or products. ACLY forms a homotetramer with a rigid citrate synthase homology (CSH) module, flanked by four flexible acetyl-CoA synthetase homology (ASH) domains; CoA is bound at the CSH-ASH interface in mutually exclusive productive or unproductive conformations. The structure of a catalytic mutant of ACLY in the presence of ATP, citrate and CoA substrates reveals a phospho-citryl-CoA intermediate in the ASH domain. ACLY with acetyl-CoA and oxaloacetate products shows the products bound in the ASH domain, with an additional oxaloacetate in the CSH domain, which could function in ACLY autoinhibition. These structures, which are supported by biochemical and biophysical data, challenge previous proposals of the ACLY catalytic mechanism and suggest additional therapeutic possibilities for ACLY-associated metabolic disorders.\nAbramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.", "domain": "chemistry", "round": 3} +{"url": "https://orbiquimica.com.br/en/produto/orbicar-2000-2/", "date": "2022-05-21T03:38:21Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-21/segments/1652662534773.36/warc/CC-MAIN-20220521014358-20220521044358-00758.warc.gz", "language_score": 0.8933073878288269, "token_count": 587, "dump": "CC-MAIN-2022-21", "global_id": "webtext-fineweb__CC-MAIN-2022-21__0__280356556", "lang": "en", "text": "ORBICAR 2000 was developed for cleaning nozzles, carbonized components and even carburetors.\nIt is fast acting and quick to dry due to its high solvency. Its combination of detergent additives and corrosion inhibitors means it will not damage injection systems and sensors.\nIdeal for the removal of grease deposits that have accumulated over time and carbonized material\nPhenol free formulation.\nPerfect for decarbonizing and cleaning carburetors, nozzles, and the entire fuel supply system. Removes grease, carbonized material and general dirt.\nHow to Use\n1. Disconnect carburetor inlet tubing and cap end.\n2. Run the engine until the fuel remaining in the carburetor is exhausted.\n3. Apply ORBICAR 2000 abundantly through the carburetor vent.\n4. Pull choke or block air inlet.\n5. Start the engine several times so that the product penetrates the entire carburetor.\n6. Wait approximately 15 minutes and then reconnect the tubing.\n7. Start the engine and readjust the air / fuel mixture if necessary.\n1. Disconnect power to the fuel pump.\n2. Run the engine until all the fuel in the line runs out.\n3. Disconnect the intake manifold from the fuel manifold.\n4. Apply to the manifold inlet, pulse nozzle several times or turn on the engine.\n5. Let the product sit for 15 minutes.\n6. Reinstall the system piping and reconnect the fuel pump electrical supply.\n7. Run the engine by accelerating rapidly several times.\nCARBONIZED COMPONENT CLEANING INSTRUCTIONS:\n1. Apply ORBICAR 2000 abundantly to the carbonization site.\n2. Let it sit for about 15 minutes.\n3. Remove the residue using a clean brush or cloth and then dry the components.\n8 – OrbiCar 2000\nBox with 12 aerosol cans 300ml\nStore in a cool and dry place. Keep away from heat sources. Keep in original packaging for preservation of product quality. Flammable product. Pressurized container.", "domain": "chemistry", "round": 3} +{"url": "https://prestigepp.com/maintenance/crystal-clear-waters-in-your-pool-2/", "date": "2024-04-14T20:01:39Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712296816893.9/warc/CC-MAIN-20240414192536-20240414222536-00755.warc.gz", "language_score": 0.8761835098266602, "token_count": 634, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__43439893", "lang": "en", "text": "Welcome to our comprehensive guide on achieving crystal clear waters in your pool! Whether you’re a seasoned pool owner or diving into maintenance for the first time, these top 10 tips will help you maintain sparkling water that’s inviting for a refreshing swim.\n1. Regular Skimming and Cleaning:\nKeeping debris out of your pool is crucial for maintaining clarity. Make it a habit to skim the surface daily and clean out leaves, bugs, and other debris from the skimmer and pump baskets.\n2. Maintain Proper pH Levels:\nMaintaining the correct pH balance (7.2 – 7.6) is essential for water clarity and swimmer comfort. Test your pool’s pH regularly and adjust as needed using pH increaser or decreaser.\n3. Shock Your Pool Weekly:\nRegular shocking helps eliminate bacteria, algae, and other contaminants that can cloud your water. Follow manufacturer instructions and shock your pool weekly, especially during hot weather or heavy pool use.\n4. Brush and Vacuum:\nBrushing the walls and floor of your pool helps prevent algae growth and removes dirt buildup. Vacuum your pool weekly to remove sediment and maintain water clarity.\n5. Monitor Chlorine Levels:\nChlorine is a powerful sanitizer that keeps your pool water clean and clear. Monitor chlorine levels regularly and adjust as needed to maintain the recommended range (1.0 – 3.0 ppm).\n6. Keep Filters Clean:\nClean filters are essential for removing impurities from your pool water. Check and clean your pool’s filters regularly according to manufacturer guidelines to ensure optimal filtration.\n7. Balance Calcium Hardness:\nMaintaining proper calcium hardness levels (200 – 400 ppm) helps prevent scale formation and cloudy water. Test your pool water regularly and adjust calcium hardness as needed using calcium chloride.\n8. Use Algaecide Preventatively:\nPrevent algae growth by using an algaecide regularly, especially during warmer months or when your pool is prone to algae blooms. Follow product instructions for dosage and application.\n9. Regular Water Circulation:\nProper water circulation is essential for distributing chemicals evenly and preventing stagnant water. Run your pool pump and filter for an adequate amount of time each day to maintain circulation.\n10. Schedule Professional Maintenance:\nRegular professional maintenance ensures your pool stays in top condition year-round. Consider hiring a professional service for routine inspections, cleaning, and maintenance tasks to keep your pool sparkling.\nBy following these top 10 essential pool maintenance tips, you can enjoy crystal clear waters in your pool all season long. Remember to stay consistent with your maintenance routine and address any issues promptly to keep your pool in pristine condition for years to come. And feel free to reach out to us if you have any questions along the way!\nDREAM IT, BUILD IT, LIVE IT\nPrestige Pool and Patio", "domain": "chemistry", "round": 3} +{"url": "https://es.slideshare.net/DaveMaske/metabolon-global-metabolomics", "date": "2021-06-13T07:06:20Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-25/segments/1623487600396.21/warc/CC-MAIN-20210613041713-20210613071713-00339.warc.gz", "language_score": 0.7221285700798035, "token_count": 1487, "dump": "CC-MAIN-2021-25", "global_id": "webtext-fineweb__CC-MAIN-2021-25__0__13804814", "lang": "en", "text": "Se ha denunciado esta presentación.\nUnlocking Biology with Global Metabolomics\nGlobal metabolomics provides an unbiased survey of known and novel metabolites\nacross nearly all metabolite classes.\nSurveying metabolites is crucial to unlocking biology because almost every factor\nimpacting the phenoytpe—from genetics and microbiota, to disease and drug\nexposure—exerts influence by altering metabolite levels.\nBy identifying, quantifying, tracking and mapping all of the metabolites of a system\nunder study, global metabolomics can provide unique biological insight and empower\nWhile many laboratories have metabolite profiling or analytical chemistry capabilities,\ncomplete global metabolomics solutions are extremely rare. This is because accurate\nand unbiased metabolite identification across the entire metabolome presents sizable\nchallenges that very few laboratories are equipped to handle.\nA Global Metabolomics Solution: The DiscoveryHD4™\nThrough 15 years of experience and continuous innovation, Metabolon has overcome\nthe challenges of whole-metabolome profiling and created the industry’s most\nadvanced global metabolomics technology—the DiscoveryHD4 Platform.\nDiscoveryHD4 delivers the most comprehensive,\nhighest-quality metabolomics data available. It\nis an ideal tool for gaining biological insight and\nDiscoveryHD4 is, effectively, an automated\n“metabolic sequencer” that unlocks critical\ninformation contained within the metabolome.\nIt can quickly and accurately identify and quantitate\nupwards of 1,000 metabolites with less than 5%\nprocess variability and is compatible with almost\nany sample type.\nThis exceptional data is then imported into our\npathway analysis environment for intuitive and\ninsightful interpretation. This combination of data\nand interpretation tools represents a unique\nsystem for creating knowledge.\nA TRULY GLOBAL REACH\nn Broad classes of known and\nn ~1,000 metabolites/sample*\nn Exceptional data quality\nn Pathway analysis based on years\nof institutional knowledge\nThe Metabolome is comprised of\nthousands of chemically and structurally\ndiverse metabolites. DiscoveryHD4 offers\nthe most comprehensive screening of this\n* The number of metabolites detected will\nvary based on service offering and sample\nThe DiscoveryHD4 platform provides the industry’s broadest class coverage from a single sample.\nTHE DiscoveryHD4 PLATFORM\nMETABOLITE COVERAGE AND METHODS.\nDiscoveryHD4 combines mass spectrometry methods and a proprietary LIMS system with the industry’s largest reference library of authenticated metabolite standards\nand a suite of patented informatics and quality-control software. This allows us to automatically and rapidly identify and quantitate metabolites. A team of chemical spectral\nanalysts then performs final quality-control using proprietary software tools. These features collectively allow DiscoveryHD4 to overcome the “signal-to-noise” challenges\nthat plague many metabolomics platforms. The result is the rapid production of the highest quality data possible.\nn A. M. Evans, B. R. Bridgewater et al., Metabolomics 4, 2153-0769 (2014).\nn A. Evans, M. Mitchell et al., Metabolomics: Open Access, (2012).\nn C. D. DeHaven, A. Evans et al., INTECH Open Access Publisher (2012).\nn C. D. Dehaven, A. M. Evans et al., J Cheminform 2, (2010).\nn A. M. Evans, C. D. DeHaven et al., Analytical Chemistry 81, 6656-6667\nDesign with Ph.D.\nEnsure design is\naligned with goal to\nAccurate Data Capture\n& Rigorous Processing\nand accurate IDs with\nlow process variability\nEnsure accurate data\ntraceability of all\nIdentify key pathways\nand receive clear\nreporting of results\nAdvanced mLIMS for\nAmino Acid Metabolism Cofactor Vitamin Metabolism Nucleotide Metabolism Microbiome Metabolism\nAmino Acid catabolism\nMany other cofactors and\nvitamins (tocopherol, B12, Biotin)\nDegradation of nucleotides\nPurine and pyrimidine de novo\nPurine and pyrimidine salvage\nAromatic amino acids\nFatty acids/short chain medium\nCarbohydrate Metabolism Energy Metabolism Lipid Metabolism Novel Metabolites\nMetabolism of other\nMetabolism of sugars (fructose,\nPentose phosphate pathway\nOxidized lipids (COX, LOX)\nNovel drug metabolites\nNovel microbiota metabolites\nNovel by-products of\nnon-canonical host metabolism\nOver 1,000 metabolites across diverse\nclasses can be measured* from 100\nμL of plasma/serum, 50-100 mg of\ntissue, or 50-100 μL cell pellet with\napproximately 5% CVs.\n* The metabolites detected from the above\nclasses can vary based on the type of\nsample and the abundance levels in\nMETABOLYNC ANALYSIS TOOLS\nCUSTOM-BUILT TOOLS FOR TRANSFORMING DATA TO KNOWLEDGE.\nDeliverables and Data Analysis Tools\nThe MetaboLync Portal allows users to download and share\ndeliverables, such as data files, reports and slide decks. It also\nprovides access to a suite of data visualization and analysis\ntools that help transform data into actionable knowledge.\nThese include the heat map tool, which allows users to\nmanipulate and compare statistical data, the pathway\nenrichment tool, which helps identify targets of interest,\nand the Pathway Visualizations Tool—Metabolon’s\ncustom-built cytoscape ® plugin, which brings all data\ntogether for a comprehensive and in-depth analysis.\nThe Pathway Visualizations plugin imports study data to create\na multi-functional data display that incorporates heat maps,\ncharts, pathway enrichment data, and an annotated biochemical\n“Network View” for each experiment. The Network View is an\ninteractive visual rendering of the data within the associated\nResults can also be viewed in the context of the whole\nmetabolome by opening the curated biochemical Pathway Map.\nThe Pathway Map is an interactive visual rendering of all charted\nbiochemical pathways. This provides a more holistic picture\nof your metabolomics study results and empowers deeper\nunderstanding of biological significance.\na richly annotated map\nof the metabolome\nfrom which you can\nquality images, and\nshare findings with\nFOR A COMPLETE LIST OF OUR METABOLOMICS SERVICES, VISIT WWW.METABOLON.COM\nClient Portal, securely hosted in the cloud, allows Metabolon clients to access, share, visualize\nand analyze their metabolomics and lipidomics study results.\nResearch Triangle Park, North Carolina\n+44 (0) 20 3 318 5807\n+34 (0) 609 106 782", "domain": "chemistry", "round": 3} +{"url": "https://www.mdpi.com/2076-3417/9/14/2800", "date": "2019-07-23T20:42:00Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-30/segments/1563195529664.96/warc/CC-MAIN-20190723193455-20190723215455-00063.warc.gz", "language_score": 0.8695650696754456, "token_count": 704, "dump": "CC-MAIN-2019-30", "global_id": "webtext-fineweb__CC-MAIN-2019-30__0__114950542", "lang": "en", "text": "A Novel Way for Whey: Cheese Whey Fermentation Produces an Effective and Environmentally-Safe Alternative to Chlorine\nAbstractCheese whey has been described as an environmental hazard due to its high organic content. Although it has been suggested that whey can be used as food disinfectant, it continues to pose an environmental problem because it still contains a high organic load. Here, we aimed to develop a low-cost, scalable fermentation protocol to produce a disinfectant from dairy waste that has very little organic content and high levels of lactic acid. Fermentation was achieved with industrial whey from ewe, goat, and cow’s milk, using a specific mesophilic-lactic acid bacteria starter mix over 120 h, which yielded the highest lactic acid production and the lowest lactose content. Antibacterial activity was observed against Listeria monocytogenes, Salmonella enterica, and Escherichia coli O157:H7, plus a total of thirteen other food pathogenic and spoilage strains, and antibacterial activities were determined to be highest after 120 h. We further validated this whey’s application as a disinfectant in shredded lettuce and compared its efficacy to that of chlorine, evaluating microbial quality, texture, color, and sensory perception, pH, and O2 and CO2 determinations. Results showed that not only was microbial quality better when using our whey solution (p < 0.05), but also the quality indicators for whey were statistically similar to those treated with chlorine. Hence, our work validates the use of an industrial waste whey as a low-cost, efficient, and environmentally safe disinfectant, with potential applications for minimally processed foodstuffs as an alternative to chlorine. View Full-Text\nShare & Cite This Article\nS. Santos, M.I.; Fradinho, P.; Martins, S.; G. Lima, A.I.; M. S. Boavida Ferreira, R.; Pedroso, L.; S. S. Ferreira, M.A.; Sousa, I. A Novel Way for Whey: Cheese Whey Fermentation Produces an Effective and Environmentally-Safe Alternative to Chlorine. Appl. Sci. 2019, 9, 2800.\nS. Santos MI, Fradinho P, Martins S, G. Lima AI, M. S. Boavida Ferreira R, Pedroso L, S. S. Ferreira MA, Sousa I. A Novel Way for Whey: Cheese Whey Fermentation Produces an Effective and Environmentally-Safe Alternative to Chlorine. Applied Sciences. 2019; 9(14):2800.Chicago/Turabian Style\nS. Santos, Maria I.; Fradinho, Patrícia; Martins, Sandro; G. Lima, Ana I.; M. S. Boavida Ferreira, Ricardo; Pedroso, Laurentina; S. S. Ferreira, Maria A.; Sousa, Isabel. 2019. \"A Novel Way for Whey: Cheese Whey Fermentation Produces an Effective and Environmentally-Safe Alternative to Chlorine.\" Appl. Sci. 9, no. 14: 2800.\nNote that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.", "domain": "chemistry", "round": 3} +{"url": "http://www.abcam.com/MEK2-antibody-ab13866.html", "date": "2013-12-07T11:53:53Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2013-48/segments/1386163054353/warc/CC-MAIN-20131204131734-00089-ip-10-33-133-15.ec2.internal.warc.gz", "language_score": 0.7861480712890625, "token_count": 912, "dump": "CC-MAIN-2013-48", "global_id": "webtext-fineweb__CC-MAIN-2013-48__0__170862796", "lang": "en", "text": "Anti-MEK2 antibody (ab13866)\n- Product nameAnti-MEK2 antibodySee all MEK2 primary antibodies ...\n- DescriptionRabbit polyclonal to MEK2\n- Tested applicationsWB more details\n- Species reactivityReacts with: Human\nPredicted to work with: Mouse, Rat\nSynthetic peptide: ARRKPVLP ALTINPTI, corresponding to amino acids 2-18 of Human MEK2\n- Positive control\n- 293 whole cell lysate.\n- Storage instructionsStore at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.\n- Storage bufferPreservative: 0.05% Sodium Azide, 0.2% Gelatin\n- Concentration information loading...\n- PurityIgG fraction\n- Purification notesThis antibody is affinity purified.\n- Clonality Polyclonal\n- Research Areas\nOur Abpromise guarantee covers the use of ab13866 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\n|WB||WB: Use a concentration of 1 - 3 µg/ml. Detects a band of approximately 45 kDa (predicted molecular weight: 48 kDa).|\n- FunctionCatalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases.\n- Involvement in diseaseDefects in MAP2K2 are a cause of cardiofaciocutaneous syndrome (CFC syndrome) [MIM:115150]; also known as cardio-facio-cutaneous syndrome. CFC syndrome is characterized by a distinctive facial appearance, heart defects and mental retardation. Heart defects include pulmonic stenosis, atrial septal defects and hypertrophic cardiomyopathy. Some affected individuals present with ectodermal abnormalities such as sparse, friable hair, hyperkeratotic skin lesions and a generalized ichthyosis-like condition. Typical facial features are similar to Noonan syndrome. They include high forehead with bitemporal constriction, hypoplastic supraorbital ridges, downslanting palpebral fissures, a depressed nasal bridge, and posteriorly angulated ears with prominent helices. The inheritance of CFC syndrome is autosomal dominant.\n- Sequence similaritiesBelongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.\nContains 1 protein kinase domain.\nmodificationsMAPKK is itself dependent on Ser/Thr phosphorylation for activity catalyzed by MAP kinase kinase kinases (RAF or MEKK1).\nAcetylation of Ser-222 and Ser-226 by Yersinia yopJ prevents phosphorylation and activation, thus blocking the MAPK signaling pathway.\n- Cardiofaciocutaneous syndrome antibody\n- CFC syndrome antibody\n- CFC4 antibody\n- Dual specificity mitogen activated protein kinase kinase 2 antibody\n- Dual specificity mitogen-activated protein kinase kinase 2 antibody\n- ERK activator kinase 2 antibody\n- FLJ26075 antibody\n- MAP kinase kinase 2 antibody\n- MAP2K 2 antibody\n- map2k2 antibody\n- MAPK / ERK kinase 2 antibody\n- MAPK/ERK kinase 2 antibody\n- MAPKK 2 antibody\n- MAPKK2 antibody\n- MEK 2 antibody\n- MEK2 antibody\n- Microtubule Associated Protein Kinase Kinase 2 antibody\n- Mitogen activated protein kinase kinase 2 antibody\n- Mitogen activated protein kinase kinase 2 p45 antibody\n- MKK 2 antibody\n- MKK2 antibody\n- MP2K2_HUMAN antibody\n- OTTHUMP00000165826 antibody\n- OTTHUMP00000165827 antibody\n- PRKMK 2 antibody\n- PRKMK2 antibody\nReferences for Anti-MEK2 antibody (ab13866)\nab13866 has not yet been referenced specifically in any publications.", "domain": "chemistry", "round": 3} +{"url": "https://iimcb.genesilico.pl/modomics/protein/104/", "date": "2023-02-07T14:28:22Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-06/segments/1674764500619.96/warc/CC-MAIN-20230207134453-20230207164453-00561.warc.gz", "language_score": 0.6658210158348083, "token_count": 1032, "dump": "CC-MAIN-2023-06", "global_id": "webtext-fineweb__CC-MAIN-2023-06__0__46366857", "lang": "en", "text": "Modomics - A Database of RNA Modifications\nTilS from Escherichia coli - protein summary.\ntRNA lysidine(34) synthetase\nPosition of modification - modification:\nt:34 - k2C\nUtilizes ATP and Lys as substrates. Homologs of this E.coli enzyme are present in almost all bacteria as well as in some eykaryota. In this last case, the enzyme catalyses k2C formation in mitochondrial tRNAIle(CAU). In Archaea, TilS does not exists but instead, there is a TiaS catalyzing the formation of agmatidine (C+ or agmt) in the same tRNAile(CAU) for the same decoding function as TilS in Bacteria (functional convergent type of evolution). While bacterial TilS is considered as an essential gene, it can be deleted after compensatory mutation occur in tRNAile(G34>U34AU).\nAn RNA-modifying enzyme that governs both the codon and amino acid specificities of isoleucine tRNA.\nSoma A, Ikeuchi Y, Kanemasa S, Kobayashi K, Ogasawara N, Ote T, Kato J, Watanabe K, Sekine Y, Suzuki T\nStructural basis for lysidine formation by ATP pyrophosphatase accompanied by a lysine-specific loop and a tRNA-recognition domain.\nNakanishi K, Fukai S, Ikeuchi Y, Soma A, Sekine Y, Suzuki T, Nureki O\nProc Natl Acad Sci U S A\nStructural basis for translational fidelity ensured by transfer RNA lysidine synthetase.\nNakanishi K, Bonnefond L, Kimura S, Suzuki T, Ishitani R, Nureki O\nDiscovery and characterization of tRNAIle lysidine synthetase (TilS).\nSuzuki T, Miyauchi K\nLife without the essential bacterial tRNA Ile2-lysidine synthetase TilS: a case of tRNA gene recruitment in Bacillus subtilis.\nFabret C, Dervyn E, Dalmais B, Guillot A, Marck C, Grosjean H, Noirot P\nCopyright © Genesilico - All rights reserved\nIf you have any advice or suggestions for corrections or improvements, please contact:\nAndrea Cappannini -", "domain": "chemistry", "round": 3} +{"url": "http://www.paintsquare.com/tag/?fuseaction=topics&tagID=1820&ctid=39", "date": "2014-12-21T02:03:26Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2014-52/segments/1418802770557.39/warc/CC-MAIN-20141217075250-00043-ip-10-231-17-201.ec2.internal.warc.gz", "language_score": 0.8076187968254089, "token_count": 267, "dump": "CC-MAIN-2014-52", "global_id": "webtext-fineweb__CC-MAIN-2014-52__0__92440807", "lang": "en", "text": "• Field Diagnosis\n• Lab Diagnosis\n• Determination of Cause\nThe proven corrosion protection\nproperties of our zinc dust prolong\nthe life of marine coatings. U.S. Zinc –\nHelping the world work™\nTermarust (HR CSA) Chemically Stops\nPipeline Utility Aerial crossings coated since 1992. Termarust's (HR CSA) was used to overcoat lead paint and preserve cables, pipes and support towers.\nMohawk Garnet™ – North American Hard Rock\nRough around the edges – which is what you want in your abrasive. More information at 1.866.642.7638 or email@example.com\nRotating water jets increase coverage\nNLB lance has rotating water jets (40,000 psi), widening the spray pattern to cover more area. Features air-driven swivel with dual triggers to enhance safety.\nSpider’s Competent Person Training\nWhat will Spider’s CPT class do for you?\n• OSHA compliance\n• Increased productivity\n• Improved safety\n• Fewer accident-related\nCall 877-774-3370 or click for classes near you.\nLearn about soluble salts, along with a discussion on\nMore information at", "domain": "chemistry", "round": 3} +{"url": "http://slideplayer.com/slide/4246417/", "date": "2018-04-27T06:53:46Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-17/segments/1524125949489.63/warc/CC-MAIN-20180427060505-20180427080505-00462.warc.gz", "language_score": 0.856634795665741, "token_count": 2411, "dump": "CC-MAIN-2018-17", "global_id": "webtext-fineweb__CC-MAIN-2018-17__0__178328325", "lang": "en", "text": "Presentation on theme: \"Carcinogenesis. Carcinogenesis refers to the process by which a normal cell is transformed into a malignant cell and repeatedly divides to become a cancer.\"— Presentation transcript:\nCarcinogenesis refers to the process by which a normal cell is transformed into a malignant cell and repeatedly divides to become a cancer. A chemical which can initiate this process is called a chemical carcinogen. Some chemicals which are non- carcinogenic or only weakly carcinogenic can greatly enhance the effectiveness of carcinogenic chemicals. Such \"helpers\" are called cocarcinogens. They may act by altering uptake or metabolism of carcinogens by cells. Carcinogenesis may take as long as 15-25 years in humans and in several animal models has been shown to involve two stages, initiation and promotion.\n-In general, carcinogens are mutagens indicating that they have the potential to interact with DNA. -Patients with DNA repair defects, such as xeroderma pigmentosum (defect in repair of damage induced by UV and bulky aromatic chemicals), have increased incidence of cancer.\nKey words: Carcinogenesis: Pathogenesis of cancer Carcinogen - agent causing cancer. Oncogen - agent causing neoplasm. Mutagen - agent causing mutation. Oncogenes – genes causing cancer p-onc, v-onc – Proto/viral/ - naming of oncogenes.\nFactors affecting carcinogenesis These factors can be divided into three main groups: Environmental Toxins chemical physical (e.g. radiation) Dietary natural products found in spices, etc. additives (rarely) Lifestyle hormonally-mediated other\nChemicals Generally Recognized as Carcinogenic in Humans Industrial Exposures Benzidine Urinary Bladder Vinyl Chloride Liver Certain tars Skin and Asbestos Peritoneum (lungs when combined with cigarette smoking) Benzene Lymphoid Tissue Other Exposures Diethylstilbestrol VaginaI Arsenic Compounds Skin cancer Cigarette Smoke Lungs, urinary tract Betal Nut Buccal Mucosa\nDiets play important roles in the development of tumors. The following factors should be considered. Natural Foods May Contain Carcinogens: Mushrooms»»Hydrazine Betal Nut»»Hydrocarbons Food contaminants: Aflatoxin B1»»Peanuts Nitrosamines»»Beer, Wine, Pickled Vegetables Food Processing: Barbecued Meat»»Polycyclic Hydrocarbons Heat Processing of Protein-Rich Foods»»Heterocyclic Aromatic compounds Dietary Fat: Saturated Fatty Acids Polyunsaturated Fatty Acids: Corn oil, Safflower oil Natural Foods May Contain Anticarcinogens»»Vitamins, Antioxidants\nMolecular Basis of Carcinogenesis Genes control cell division by cytokines. Four important classes of regulatory genes (for cell division): 1. Promotors – Proto-oncogenes 2. Inhibitors – Tumor or Cancer-suppressor genes – p53 3. Genes regulating Apoptosis. 4. DNA repair genes.\nCarcinogenesis Genetic mutations are largely responsible for the generation of malignant cells. Two major categories of mutated genes are oncogenes and tumor suppressor genes. 1-Oncogenes are abnormal forms of normal genes called proto-oncogenes that regulate cell growth. Mutation of these genes may result in direct and continuous stimulation of the molecular biologic pathways that control cellular growth and division. For example, the ras gene encodes the Ras protein, which regulates cell division. Mutations may result in the inappropriate activation of the Ras protein, leading to uncontrolled cell growth and division.\n2-Tumor suppressor genes,p53, are inherent genes that play a role in cell division and DNA repair and are critical for detecting inappropriate growth signals in cells. If these genes, as a result of inherited or acquired mutations, become unable to function, genetic mutations in other genes can proceed unchecked, leading to neoplastic transformation. Another important regulatory protein, prevents replication of damaged DNA in normal cells and promotes cell death (apoptosis) in cells with abnormal DNA. Inactive or altered apoptotic genes allows cells with abnormal DNA to survive and divide.\np53 Gene p53 senses DNA damage, and induces G1 arrest and induces DNA repair process. Cell with un-repairable DNA is directed to apoptosis by p53 gene. “P53 is a guardian of the genome. Its loss leads to accumulation of damaged DNA may result in malignancy” Loss of p53 is seen in virtually every type of cancer. Over half of human malignant cells show loss of p53 gene by special tests.\nNon-lethal Genetic damage lies at the center of carcinogenesis. Loss/damage to suppressor genes, Duplication of promotor genes Loss/damage to Apoptosis genes Loss/damage of DNA repair genes.\nMolecular Basis of Neoplasia: Proto-oncogene Oncogene V-Onc Other Heredity Radiation Chemical\nViral Oncogenesis Viruses contribute to the pathogenesis of human malignancies through the integration of viral genetic elements into the host DNA. These new genes are expressed by the host; they may affect cell growth or division, or disrupt normal host genes required for control of cell growth and division. Alternatively, viral infection may result in immune dysfunction, leading to decreased immune surveillance for early tumors. Insertion of viral nucleic acids mutation Alterations in Oncogenes, cancer suppressor genes and genes regulating DNA repair resulting in up-regulation of cell division Carcinogenesis. Human Papilloma Virus Cervical neoplasia – warts, papilloma, ca cx Epstein-Barr virus – Burkitts Lymphoma, Nasopharyngeal ca. Hepatitis B & C virus Hepatocellular carcinoma.\nRadiation Carcinogenesis: Ionizing radiation Carcinogenesis can result from ionizing radiation and may develop from 2 different mechanisms; 1. Direct ionization – damages DNA and other molecules can cause direct somatic mutations 2. Secondary effectors such as oxygen radicals can be formed by ionizing radiation. Oxygen free radicals can damage and kill cells and also induce mutations. X Ray workers – Leukemia Radio-isotopes – Thyroid carcinoma Atomic explosion – Skin cancer, Leukemia\nSummary DNA damage - loss of control over cell division. Radiation, Chemicals & Viral infections are some known causes of cancers. Cancer evolves in multiple steps by sequentially acquiring different DNA damages. Initiation, Latent stage, Promotion and Malignant transformation are recognizable stages in carcinogenesis. Each character of malignancy depends on unique DNA alteration.\nCarcinogenesis Initiation DNA damage eg.Benzpyrene Promotion Histologic change – eg. Turpentine (co-carcinogens) Malignant transformation: Visible tumor formation – further DNA damage.\nInitiation - point at which an irreversible alteration, usually genetic, is introduced into a target cell. (genotoxicity)=Interaction with DNA May involve conversion of proto-oncogen to oncogen Initiation: (1) is essentially irreversible (2) caused only by carcinogenic compounds (3) occurs rapidly after carcinogen exposure (4) alone does not result in tumor formation Several exposures to an initiator may result in tumor without presence of a promoter.\nPromotion is the process whereby an initiated tissue or organ develop focal proliferations and it requires the presence of continuous stimulation. A promotor: is a substance which doesn't damage DNA but enhance growth of tumor induced by genotoxic carcinogens e.g.: skin cancer in mice can be induced by application of benzo [α ] pyrene ( initiator) followed by phorbol ester from cotton oil ( promoter). Promotion (1) reversible (2) acts only after exposure to an initiating agent (3) requires repeated administration of a promoter (4) is not carcinogenic in itself\nEtiology and Pathogenesis of Neoplasia Initiation and Promotion\nChemical Carcinogenesis In general, chemical carcinogens are electrophiles or can be metabolically converted to electrophiles. (by metabolic activation ) These electrophiles can react with nucleophilic centers (predominantly N and O and to some extent S) in cellular macromolecules such as DNA, RNA and protein.\nClassification of Carcinogens Genotoxic – Act directly on DNA or expression of DNA during translation. DNA replication errors. Point mutations. Chromosomal aberration. Epigenetic – Non-DNA reactive. – Potentiators. – Ex.: hormone, immune function modifiers\nGenotoxic Carcinogen Chemical capable of producing cancer by directly altering the genetic material of target cells. 1- Direct carcinogens (no metabolic activation). – Alkylating agents. 2-Indirect carcinogens (metabolic activation). – Polycyclic aromatic hydrocarbons. – Aromatic amines. – Nitrosamines. – Natural substances. 3– Inorganic carcinogens. 4- Ni, Cr, Cd, As.\nChemicals Generally Recognized as Carcinogenic in Humans Industrial Exposures Benzidine Urinary Bladder Vinyl Chloride Liver Mesenchyme Certain tars Skin and Asbestos Peritoneum (lungs when combined with cigarette smoking) Benzene Lymphoid Tissue Other Exposures Diethylstilbestrol VaginaI Arsenic Compounds Skin cancer Cigarette Smoke Lungs, urinary tract Betal Nut Buccal Mucosa\nDiet & nutrients protecting from cancer : Fruits & vegetables * High level of fibers * Antioxidants which decrease damaging effects caused by free radicals and reactive oxygen species on DNA Examples: a- Tocopherol & β- carotene ( carotenoids), vit C : decrease tumor incidence. b- Tomatos : contain lycopene protect against prostate cancer. c- Green tea : contain polyphenols which act as antioxidants. d- Red grapes : contain resveratrol which acts an antioxidant. Garlic & onions ( allylsulphide + diallylsulphide) : * They inhibit Cyt P450 ( Phase I) which converts percarcinogents to carcinogens * They activate glutathione-s- transferase ( GSTs ) which help conjugation of carcinogens with cellular GSH ( Phase II)\nCruciferous vegetables : * Eg: Cabbage - broccoli. They contain dithiol thiones & isothiocyanates which activate phase II enzymes that help eliminating the carcinogen. Omega 3 fatty acids: eg : fish oil They crowd other fats replacing them inside the cells, thus preventing their promoter action. Soy products: * Contain weakly estrogenic isoflavonoids * These isoflavonoids compete with estrogen for its peripheral receptors on breast blocking them, ttt of estrogen – dependant breast cancer ( as tamoxifen ).\nRed grapes : * Red grapes contain resveratrol & tumeric contains curcumin. * tumor cells secrete factor that promotes the development of new blood vessels which are necessary for tumor growth ; this process is know as angiogenesis. Resveratrol & curcumin suppress the release of growth factors by the tumor inhibit angiogenesis.\nPrinciple of Treatment Surgical therapy – early stage/debulk Chemotherapy Radiotherapy Immunotherapy\nIt is easy to kill cancer cells, but the challenge is keeping the patient alive at the same time…..!", "domain": "chemistry", "round": 3} +{"url": "https://www.dictionary.com/browse/pyridostigmine-bromide", "date": "2023-01-29T19:24:10Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-06/segments/1674764499758.83/warc/CC-MAIN-20230129180008-20230129210008-00722.warc.gz", "language_score": 0.9019861221313477, "token_count": 285, "dump": "CC-MAIN-2023-06", "global_id": "webtext-fineweb__CC-MAIN-2023-06__0__237024605", "lang": "en", "text": "Words nearby pyridostigmine bromide\nHow to use pyridostigmine bromide in a sentence\nHe was adept at deflecting a direct question with an anecdote or a bromide presented as a confidence.\nIn executions, that drug is pancuronium bromide, a type of curariform, or neuromuscular-blocking agent.\nVeterinarians object to the use of the second drug, the pancuronium bromide, because it presents as unnecessary risk of suffering.\nAt the end, however, he treats viewers to a poli-sci bromide that we could really have done without.\nBromide of potassium is generally recognised as the most effective anti-epileptic remedy we at present possess.A Statistical Inquiry Into the Nature and Treatment of Epilepsy|Alexander Hughes Bennett\nIn brief, film is a cellulose base coated with silver bromide and gelatine.\nNow only the image-forming silver bromide particles remain, and these have been transformed to metallic silver.\nThe Doctor started to give him some fresh advice—but left him a bromide instead.Molly Make-Believe|Eleanor Hallowell Abbott\nIt forms white prismatic crystals; and, in its general properties, resembles bromide of potassium.", "domain": "chemistry", "round": 3} +{"url": "https://www.matec-conferences.org/articles/matecconf/abs/2018/51/matecconf_iceast2018_03042/matecconf_iceast2018_03042.html", "date": "2023-02-02T14:25:16Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-06/segments/1674764500028.12/warc/CC-MAIN-20230202133541-20230202163541-00615.warc.gz", "language_score": 0.8630308508872986, "token_count": 640, "dump": "CC-MAIN-2023-06", "global_id": "webtext-fineweb__CC-MAIN-2023-06__0__119082110", "lang": "en", "text": "MATEC Web Conf.\nVolume 192, 2018The 4th International Conference on Engineering, Applied Sciences and Technology (ICEAST 2018) “Exploring Innovative Solutions for Smart Society”\n|Number of page(s)||4|\n|Section||Track 3: Food, Chemical and Agricultural Engineering|\n|Published online||14 August 2018|\nThe effect of ethoxylate nonionic surfactants on phase inversion temperature and salinity: an alternative approach for vegetable oil recovery from spent bleaching earth\nFaculty of Agriculture, Natural Resources and Environment, Naresuan University, Thailand.\n2 Petroleum and Petrochemical College, Chulalongkorn University, Thailand.\n* Corresponding author: firstname.lastname@example.org (N. Arpornpong).\nAn accurate determination of the hydrophilic-lipophilic nature of surfactants plays an important role in guiding microemulsion formation. The objective of this study is to determine the effect of ethoxylate numbers (EONs) (3, 5, and 7 moles) of nonionic surfactants on a phase inversion temperature (PIT) and optimum salinity based on the equivalent alkane carbon numbers (ACNs) of vegetable oils. Three vegetable oils, soybean oil, crude rice bran oil and crude palm oil, were selected for use as a surrogate oil to represent the residual oils found in spent bleaching earth. In this study, the hydrophilic-lipophilic deviation (HLD) was used to predict the optimum salinity (0-20 %wt.) at various temperatures (25-55°C). The results showed that the ACNs of crude rice bran oil, crude palm oil, and soybean oil were 15.41±0.35, 13.71±0.41, and 17.60±0.28, respectively. In comparison, these predictions with the experimental results, the data showed slight deviations in the optimum salinity with the specific temperature. Finally, the ACN and the surfactant characteristics obtained in this study were combined with the HLD equation and used to validate its practically and utility for guiding the optimum microemulsion formulation.\n© The Authors, published by EDP Sciences, 2018\nThis is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.\nCurrent usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.\nData correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.\nInitial download of the metrics may take a while.", "domain": "chemistry", "round": 3} +{"url": "https://iovs.arvojournals.org/article.aspx?articleid=2400645", "date": "2024-02-23T10:58:36Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707947474377.60/warc/CC-MAIN-20240223085439-20240223115439-00320.warc.gz", "language_score": 0.9274757504463196, "token_count": 581, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__88457618", "lang": "en", "text": "Purchase this article with an account.\nJ. Gonzalez–Meijome, A. López–Alemany, J. Almeida, M. Parafita; Microscopic Observations of Silicone Hydrogels With Three Different Techniques . Invest. Ophthalmol. Vis. Sci. 2005;46(13):909.\nDownload citation file:\n© ARVO (1962-2015); The Authors (2016-present)\nPurpose: The mechanical impact of silicone hydrogel contact lenses (SHCL) on corneal surface has been considered and the surface structure of these lenses could be important in several aspects of clinical response of the ocular surface. Scanning electron microscopy (SEM) has been previously applied to contact lens polymers, as well as atomic force microscopy (AFM). The purpose of this study was to observe different silicone hydrogel contact lens materials by three microscopic techniques in order to identify which one give us more representative information of the surface polymer structure. Methods: Contact lens materials included lotrafilcon A, balafilcon A and galyfilcon A. Microscopic techniques used in this study were AFM, SEM and cryo–scanning electron microscopy (cryoSEM). AFM statistics (tapping mode) including mean roughness (Ra) and maximum high (Rmax) were explored for the three lens materials. Results: The three materials showed a different surface configuration when observed by either method of microscopy. However, AFM technology allows us to study the sample in the hydrated state which is very important with hydrogels. AFM also allow us to study portions of the surface as small as 0.25 square microns with high resolution. Resolution at high magnification was one of the major limitations of SEM and CryoSEM, which also induce serious damage to the sample during the preparation–fixation process. However other features have been observed with these two methods that had not been reported before, particularly with cryoSEM. AFM statistics revealed a significantly more irregular surface of the Balafilcon A material (Ra=6,44nm;Rmax=96,82) when compared with Lotrafilcon A (Ra=2,40nm;Rmax=40,89) and Galyfilcon A (Ra=1,40nm;Rmax=15,33), for a 1 µm2 area. Conclusions: The present study addresses the microscopic comparison of current SHCL pointing out the benefits of each technique. It also shows the value of cryoSEM for the study of polymeric samples from contact lenses. Present observations could have implications in clinical aspects of contact lens wear as material spoliation, resistance to bacterial adhesion or mechanical interaction with the ocular surface.\nThis PDF is available to Subscribers Only", "domain": "chemistry", "round": 3} +{"url": "http://www.programmaster.org/PM/PM.nsf/UpcomingSymposia/17B3E7FD88EF13CE852583A80064A1E4?OpenDocument&ParentUNID=EB8595226BB57C208525831F00014E65", "date": "2019-09-19T13:18:38Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-39/segments/1568514573519.72/warc/CC-MAIN-20190919122032-20190919144032-00204.warc.gz", "language_score": 0.9119024276733398, "token_count": 598, "dump": "CC-MAIN-2019-39", "global_id": "webtext-fineweb__CC-MAIN-2019-39__0__114730209", "lang": "en", "text": "||The objective of this symposium is to provide scientific community with an introduction to, and sound base and further insight for the understanding of bulk metallic glasses and their composites. Over a period, many studies have been carried out engulfed around understanding mechanisms of formation of these materials by various modeling and simulation and experimental techniques. However, still there is research gap in understanding how glass is formed, what is its nature, what is glass forming ability, how it can be improved, what is rejuvenation (mechanical and thermal), what is relaxation, how composite structure is formed, how crystallization could be tuned, how it could be studied and how it effects final properties? These a few of many open research questions. Aim of present symposium is to provide an answer to these.\nA new class of sulfur bearing metallic glasses is also introduced. These encompass superior properties such as enhanced glass forming ability and refined microstructure. A special focus is laid on embrittlement and brittleness in metallic glasses, difference, evolution and ductile to brittle transition. Light is also shed on understanding sample size and its variability and method of testing (indentation, impact or bending (mode I, II and III)) on fracture toughness. A special section is dedicated on hall-petch like relations developed for bulk metallic glass matrix composites to quantify mechanical properties. Further, fundamental scientific concepts are aimed to be employed to metallic glass matrix composites. These range from observations of incipient small transitory cluster of atoms, to rise of liquid like regions in glass prior nucleation to delay time, shift of Tg and recent pikes observed in ultrafast calorimetry spectra. All these point towards existence of certain fundamental underlying scientific phenomena which may, or may not point towards formation and evolution of crystal phase from within glass (homogeneous nucleation) or after glass (heterogeneous nucleation) formation.\nFocus areas are;\n- Glass formation and its nature (thermodynamics, ordering, its range and transitions)\n- Alloying elements (Al, S, Ag, Mo)\n- Microstructure tuning (nucleation starvation, copious nucleation, nanoscale heterogeneity, metastability and iteration)\n- Deformation mechanisms (in-situ studies, shear bands, slip avalanches, dynamics, heating), brittleness and fracture toughness\n- Fatigue, creep, torsion, corrosion and tribology (friction, erosion and wear)\n- Advanced characterization (including synchrotron, neutron scattering, ultrafast calorimetry and micro and zero gravity experiments)\n- Advanced forming (thermoplastic forming, co-extrusion, powder metallurgy (including plasma sintering) and Additive Manufacturing / 3D printing)\n- Modeling and simulation (macroscopic part scale, microscopic and atomistic) and machine learning\n- Extreme (including cryogenic and irradiation) engineering applications", "domain": "chemistry", "round": 3} +{"url": "https://www.esmagazine.com/articles/89816-researchers-develop-new-tool-to-detect-agents-of-bioterrorism", "date": "2024-03-03T16:04:54Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707947476396.49/warc/CC-MAIN-20240303142747-20240303172747-00348.warc.gz", "language_score": 0.9282177686691284, "token_count": 311, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__16334513", "lang": "en", "text": "High-traffic facilities like airports, office buildings, rail stations, and sporting arenas serve hundreds of thousands of people each day, making them particularly susceptible to silent and invisible biological attacks. Researchers from Lawrence Livermore National Laboratory in California have now developed a new stand-alone detector that can provide early warning to help authorities limit exposure and start treating victims before they show symptoms of full-blown infection.\nThe instrument, called the Autonomous Pathogen Detection System, or APDS, continuously monitors the air like a \"biological smoke detector,\" said John Dzenitis, Ph.D., a chemical engineer at LLNL and corresponding author of the paper. It is capable of detecting and identifying three types of biological agents: bacteria, viruses, and toxins, including such familiar threats as anthrax, plague, and botulinum toxin. The machine runs the same tests that molecular biologists would carry out in a laboratory to detect biological agents, providing information that is required before definitive public-health action can be taken.\nLLNL has been working on this instrument since 1995, but this new version, tested at the U.S. Army's Dugway Proving Grounds in Utah, is a step-change in capability, Dzenitis said. Now, in addition to simultaneously testing for multiple agents with protein antibodies, the APDS also confirms positive results with a DNA test specific for the agent. No other field system has two independent molecular biology tests. Having two laboratory-quality tests further reduces the probability of a false alarm and gives confidence for effective response.", "domain": "chemistry", "round": 3} +{"url": "http://www.labome.org/gene/fruit/gycalpha99b-43493.html", "date": "2021-01-25T23:33:32Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-04/segments/1610704792131.69/warc/CC-MAIN-20210125220722-20210126010722-00704.warc.gz", "language_score": 0.7189220190048218, "token_count": 744, "dump": "CC-MAIN-2021-04", "global_id": "webtext-fineweb__CC-MAIN-2021-04__0__235236980", "lang": "en", "text": "Genomes and Genes\nGene Symbol: Gycalpha99B\nDescription: Guanylyl cyclase alpha-subunit at 99B\nAlias: CG1912, Dgc1, Dgcalpha1, Dmel\\CG1912, GCalpha1, GYCa 99B, Gcalpha1, Gycalpha-99B, Gycalpha63A, SGCalpha, dgc1, dgca1, dgcalpha1, gycalpha, sGC, sGCalpha1, sGCalpha99B, guanylyl cyclase alpha-subunit at 99B, CG1912-PA, Gycalpha99B-PA, guanyl cyclase alpha-subunit at 63A, guanylate cyclase 99B, soluble guanylate cyclase, soluble guanylyl cyclase alpha\nSpecies: fruit fly\n- Brenman J, Gao F, Jan L, Jan Y. Sequoia, a tramtrack-related zinc finger protein, functions as a pan-neural regulator for dendrite and axon morphogenesis in Drosophila. Dev Cell. 2001;1:667-77 pubmed\n- Morton D. Atypical soluble guanylyl cyclases in Drosophila can function as molecular oxygen sensors. J Biol Chem. 2004;279:50651-3 pubmed..This is the first demonstration of a soluble guanylyl cyclase that is activated in response to changing oxygen concentrations. ..\n- Morton D, Langlais K, Stewart J, Vermehren A. Comparison of the properties of the five soluble guanylyl cyclase subunits in Drosophila melanogaster. J Insect Sci. 2005;5:12 pubmed..Two of these genes code for subunits, Gycalpha-99B and Gycbeta-100B, which form a conventional NO-sensitive guanylyl cyclase and the other three code for ..\n- Rabinovich D, Yaniv S, Alyagor I, Schuldiner O. Nitric Oxide as a Switching Mechanism between Axon Degeneration and Regrowth during Developmental Remodeling. Cell. 2016;164:170-182 pubmed publisher..Taken together, these results suggest that NO signaling provides a switching mechanism between the degenerative and regenerative states of neuronal remodeling. ..\n- Yoshikawa S, Miyamoto I, Aruga J, Furuichi T, Okano H, Mikoshiba K. Isolation of a Drosophila gene encoding a head-specific guanylyl cyclase. J Neurochem. 1993;60:1570-3 pubmedWe have isolated and characterized a new guanylyl cyclase gene (dgc1) in Drosophila. The deduced amino acid sequence (683 amino acids) most closely resembled the mammalian soluble-type guanylyl cyclase alpha subunit...\n- Kanao T, Sawada T, Davies S, Ichinose H, Hasegawa K, Takahashi R, et al. The nitric oxide-cyclic GMP pathway regulates FoxO and alters dopaminergic neuron survival in Drosophila. PLoS ONE. 2012;7:e30958 pubmed publisher..Nitric oxide synthase (NOS) and soluble guanylyl cyclase (sGC) also increased FoxO's activity, whereas the administration of a NOS inhibitor L-NAME suppressed the loss of DA ..", "domain": "chemistry", "round": 3} +{"url": "https://www.medical-xprt.com/articles/electronic-cigarettes-disrupt-lung-lipid-homeostasis-and-innate-immunity-independent-of-nicotine-827384", "date": "2022-06-26T19:50:39Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-27/segments/1656103271864.14/warc/CC-MAIN-20220626192142-20220626222142-00000.warc.gz", "language_score": 0.9013730883598328, "token_count": 1075, "dump": "CC-MAIN-2022-27", "global_id": "webtext-fineweb__CC-MAIN-2022-27__0__207051289", "lang": "en", "text": "Electronic cigarettes disrupt lung lipid homeostasis and innate immunity independent of nicotine\nElectronic nicotine delivery systems (ENDS) or e-cigarettes have emerged as a popular recreational tool among adolescents and adults. Although the use of ENDS is often promoted as a safer alternative to conventional cigarettes, few comprehensive studies have assessed the long-term effects of vaporized nicotine and its associated solvents, propylene glycol (PG) and vegetable glycerin (VG). Here, we show that compared with smoke exposure, mice receiving ENDS vapor for 4 months failed to develop pulmonary inflammation or emphysema. However, ENDS exposure, independent of nicotine, altered lung lipid homeostasis in alveolar macrophages and epithelial cells. Comprehensive lipidomic and structural analyses of the lungs revealed aberrant phospholipids in alveolar macrophages and increased surfactant-associated phospholipids in the airway. In addition to ENDS-induced lipid deposition, chronic ENDS vapor exposure downregulated innate immunity against viral pathogens in resident macrophages. Moreover, independent of nicotine, ENDS-exposed mice infected with influenza demonstrated enhanced lung inflammation and tissue damage. Together, our findings reveal that chronic e-cigarette vapor aberrantly alters the physiology of lung epithelial cells and resident immune cells and promotes poor response to infectious challenge. Notably, alterations in lipid homeostasis and immune impairment are independent of nicotine, thereby warranting more extensive investigations of the vehicle solvents used in e-cigarettes.\nThe electronic nicotine delivery system (ENDS), or e-cigarette, entered the US market in the mid-2000s and rapidly gained popularity among tobacco smokers and never-smokers (1). Currently, an estimated 10 million US adults and over 3 million high school age adolescents are active ENDS users (2, 3). Notably, ENDS have become the most commonly consumed tobacco substitute in the adolescent population, fueling concerns over the health-related consequences of ENDS exposure (4). A large contributor to the public appeal of ENDS among both adults and adolescents is the effective delivery of nicotine in the form of a vapor composed of the vehicle solvents propylene glycol (PG) and vegetable glycerin (VG), thereby circumventing the need for tobacco combustion. The popularity of ENDS has been further augmented by the additional flavorings that can be added to ENDS solutions. Over 7,000 flavors are available to accompany ENDS devices currently, which add essences of fruit or candy to enhance the experience of “vaping” (5).\nENDS-related studies often examine their addictive properties and the enticing advertising campaigns used by e-cigarette companies, which target impressionable youth (6). Specifically, studies have found that early ENDS use in teenagers may increase the risk for tobacco smoking later in life as they exhibit increased intention to smoke traditional cigarettes compared with those who have never used ENDS (7, 8). Moreover, toxicological studies have highlighted the potential health concerns of ENDS by revealing detectable levels of both heavy metals and carbonyls, such as formaldehyde and acrolein, in the vapor produced by some of the devices (9–11). Further, terms such as “popcorn lung” have become synonymous with ENDS among their opponents for the deleterious diacetyls detected in ENDS-associated flavorings (12). In contrast, other reports have advocated the safety of the products over traditional tobacco cigarettes (13, 14), thus emphasizing the unmet need to better understand the health-related consequences of exposure to e-cigarette components.\nMultiple case reports have described atypical types of pneumonia in ENDS users (15, 16). A shared feature in these reports is the presence of lipid-laden macrophages found in the bronchoalveolar lavage (BAL) fluid from individuals with ENDS-associated pneumonia (15, 16). Despite this commonality, the physiological importance of lipid accumulation and whether this phenomenon can be recapitulated in experimental systems remain unknown. Lipid metabolism is critical for proper cellular function in all tissues. Pulmonary surfactant and lipid homeostasis in the distal airways are essential for adequate gas exchange and innate immune function (17). Pulmonary surfactant, a complex mixture of lipids and proteins produced exclusively by alveolar type II pneumocytes (ATIIs), forms a critical part of the alveolar-lining fluid (18). Surfactant reduces alveolar surface tension, thereby preventing lung atelectasis, ventilation perfusion mismatch, and hypoxemia (19). Surfactant protein A (SP-A) and surfactant protein D (SP-D), 2 components of the surfactant complex, play essential roles in innate immune defense by facilitating microbial opsonization and clearance (20). To maintain the integrity of the surfactant complex, alveolar macrophages catabolize altered or oxidized surfactant in the distal liquid-air interface, which is critical for responses to inhaled pathogens (21). Impairment of macrophage metabolism of pulmonary surfactant leads to accumulation of intracellular lipid and deposition of excess lipid in the alveolar space (22).", "domain": "chemistry", "round": 3} +{"url": "https://theconversation.com/can-this-new-anti-ageing-supplement-turn-back-the-clock-126795", "date": "2024-04-22T03:11:42Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712296818072.58/warc/CC-MAIN-20240422020223-20240422050223-00521.warc.gz", "language_score": 0.9697784185409546, "token_count": 799, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__27998295", "lang": "en", "text": "Increases in lifespan are one of the greatest success stories of modern society. Yet while most of us can expect to live longer, we are spending more years in ill health. Reducing this period of ill health at the end of life is the main aim of a group of scientists known as biogerontologists.\nBy studying ageing in animals, including fruit flies, worms and rodents, biogerontologists have identified biological phenomena involved with ageing that all these organisms share. And some of these biological processes may also regulate ageing in humans.\nScientists attempting to understand and improve the ageing process have identified many molecules that appear to improve ageing in these animals (although evidence in humans remains scant). These molecules include compounds found in grapes, apples and even bacteria.\nRecently, a new molecule has been added to the list of possible anti-ageing drugs: nicotinamide adenine dinucleotide or NAD+ for short. As we age, levels of NAD+ decrease in many tissues of the body. As NAD+ is involved in many important biological processes, it is thought that this decline might contribute to ageing.\nResearch in mice has shown that replenishing NAD+ can improve many elements of ageing, including age-associated weight gain, enhanced physical activity, improved ability of the body to process carbohydrates and fats, and improved eye function. This has led some scientists to believe that increasing NAD+ levels is an exciting potential anti-ageing therapy. Indeed, a new anti-ageing supplement called Nuchido TIME+, which is said to boost NAD+ levels, was recently launched in Las Vegas. Nichola Conlon, the founder of the company that makes the supplements, described the pills as a “breakthrough product in the world of anti-ageing”.\nTheir research has suggested that Nuchido Time+ increases NAD+ in middle-aged people to the levels of someone 15 years younger. So should we all start taking NAD+ supplements?\nTo guide this decision, we need to first understand the underlying research that has led to this product being released. Almost all the research into NAD+ and ageing has taken place using cells or animals – not people. Although there are shared biological pathways that link ageing in animals and humans, human ageing is significantly more complex due to the markedly longer length of our lifespan and the complexity of our lifestyles.\nIt is very difficult to design a study that truly tests anti-ageing therapies because of ethical implications, the length of time humans live for and our complex lifestyles. Instead, studies on human ageing tend to focus on specific age-related conditions or biological changes that seem to occur naturally with age.\nEvidence for NAD+ supplements\nThe results reported by Nuchido just tell us that they have been able to increase NAD+ levels more than anyone else, not that this increase has had any measurable improvement in people’s ageing under strict scientific conditions. This evidence may yet come but, for now, what we can say is that if you take Nuchido Time+ you are likely to replenish your NAD+ levels. There is some evidence that NAD+ levels may be improved without the need for supplements, with dietary changes and exercise both being reported to alter NAD+ levels in some tissues.\nWhile there is evidence that taking supplements to increase NAD+ levels is safe, there is very little evidence yet that NAD+ supplementation works as an anti-ageing agent in humans. One study has reported that NAD+ supplementation in older adults affected muscle cells, but beyond this, there is little to demonstrate that replenishing NAD+ has a marked impact on ageing.\nMuch more robust, controlled studies are needed before the effects of NAD+ supplementation on human ageing are better understood. For now, as Nuchido Time+ costs £55 for a 30-day supply, it may be better to focus on factors that are well established at improving ageing, such as eating a healthy diet and getting regular exercise.", "domain": "chemistry", "round": 3} +{"url": "https://armyquartermaster.tpub.com/Qm4916a/Analyze-Entries-On-Water-Reports-Logs-And-Forms-27.htm", "date": "2023-09-29T18:05:22Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233510520.98/warc/CC-MAIN-20230929154432-20230929184432-00748.warc.gz", "language_score": 0.8663808107376099, "token_count": 388, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__209454733", "lang": "en", "text": "ANALYZE ENTRIES ON WATER REPORTS, LOGS, AND FORMS\nCritical Task: 101-540-3024\nThis lesson covers the procedures for analyzing entries on water reports, logs, and forms.\nTERMINAL LEARNING OBJECTIVE:\nAnalyze entries on water reports, logs, and forms.\nYou will be given completed DA Forms 1713-R, 1714-R, 1714-1-R, and 5456-R.\nAnalyze completed DA Forms 1713-R, 1714-R, 1714-1-R, and 5456-R for accurate water\nproduction, distribution, and storage operations. Use the analysis to program maintenance,\norder supplies, and develop work schedules.\nThe material contained in this lesson was derived from the following publications: FM 10-52,\nFM 10-52-1, TB MED 577, and STP 10-77W14-SM-TG.\nIn analyzing entries on water reports, logs, and forms, you will first analyze completed DA Forms 1713-R, for\naccurate recording of water production operations, to include hourly chemical dosage and ROWPU gage and\nindicator readings. You will then analyze completed DA Forms 1714-R for accurate recording of water issue\noperation, to include time, amount of water issued, using unit, and chlorine residual. You will analyze completed\nDA Forms 1714-1-R for accurate recording of GS water distribution operations, to include time, amount of water\nreceived, amount of water distributed, amount of water storage available, and chlorine residual. You will develop", "domain": "chemistry", "round": 3} +{"url": "http://products.invitrogen.com/ivgn/product/701267", "date": "2013-05-22T23:14:53Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2013-20/segments/1368702454815/warc/CC-MAIN-20130516110734-00030-ip-10-60-113-184.ec2.internal.warc.gz", "language_score": 0.886855959892273, "token_count": 615, "dump": "CC-MAIN-2013-20", "global_id": "webtext-fineweb__CC-MAIN-2013-20__0__101977418", "lang": "en", "text": "This purified ABfinity™ recombinant rabbit monoclonal antibody recognizes MAP2K1 [pSpS217/221] in human samples. ABfinity™ antibody characteristics include:\n• Validation in Western blot and indirect ELISA\n• Superior lot-to-lot consistency\n• Extremely high specificity and sensitivity\n• Recombinant rabbit monoclonal antibody\n• Specific for MAP2K1 [pSpS217/221]\nMAP2K1 [pSpS217/221] is a dual specificity mitogen-activated protein kinase (MAPK) kinase also known as MEK. It is an essential component of the MAP kinase pathway and stimulates the enzymatic activity of MAP kinases in response to signals. Growth factors, cytokines, and proto-oncogenes transduce their signals through the activation of RAS, which leads to activation of the serine/threonine kinase RAF, and then to activation of MAPK kinase or MEK. This kinase is activated by Raf family member p74raf-1 through phosphorylation of Ser residues at positions 217 and 221 in the activation loop. MEK phosphorylates and activates MAPK, also known as extracellular signal-regulated kinase (ERK) (1).Exceptional Consistency Saves You Time and Money\nABfinity™ antibodies are produced by transfection of mammalian cells with heavy and light chain antibody cDNAs. This provides you with the highest consistency between lots, eliminating the need to revalidate your assays for each lot. High Specificity Means More Reliable Data\nThe proprietary recombinant technology employed in the production of ABfinity™ antibodies means you are assured of the greatest degree of reliability. Staining of nonspecific proteins is virtually eliminated while very high sensitivity is achieved. Invitrogen has validated this antibody in Western blotting. High Sensitivity Lets You Detect Low Levels of Target Protein\nABfinity™ antibodies demonstrate much higher sensitivity than ordinary antibodies. Proteins expressed in low levels can be detected with high specificity allowing you to use less of your precious samples than with ordinary antibodies. Recombinant Rabbit IgG—Use Like Any Other IgG Antibody\nAs with traditional IgG antibodies, gel electrophoresis of ABfinity™ antibodies produces a 150 kDa band under non-reducing conditions and 50 kDa and 25 kDa bands under reducing conditions.\nFor Research Use Only. Not intended for any animal or human therapeutic or diagnostic use. Related Links:Learn more about the superior performance of ABfinity™ recombinant monoclonal antibodies\n. See Invitrogen's full line of ABfinity™ recombinant monoclonal antibodies\nAlessi DR et al., EMBO J. 1994 Apr 1;13(7):1610-9.Identification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1.", "domain": "chemistry", "round": 3} +{"url": "https://gulfbusiness.tradeholding.com/default.cgi/action/viewcompanies/companyid/547295/", "date": "2021-06-18T16:00:07Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-25/segments/1623487637721.34/warc/CC-MAIN-20210618134943-20210618164943-00238.warc.gz", "language_score": 0.8235212564468384, "token_count": 267, "dump": "CC-MAIN-2021-25", "global_id": "webtext-fineweb__CC-MAIN-2021-25__0__200216355", "lang": "en", "text": "|Experience specialist in the all processing of\ngarments, quality control, development,\nwashing, dyeing, special effects, machinery\nand consulting over 29 years.\nI have experiences in practice from 1983 in\nthe all wet and dry processing of garments\nlaundries and dye houses such as: The ideal\nusing of chemical products of washing,\ndyeing, special treatments, special effect,\nprofessional quality control (before and\nafter treatments), controlling of the cost\nof each processing, the development and\napplication of ideas of customers, the\napplication of new technologies in\nproduction, training of staff operators\nabout garment laundries and dye houses,\nreorganization of production,\nreorganization of methods of washing,\ndyeing, direct dyes, reactive dyes, pigment\ndyes, sulphur dyes, special effects, laundry\nmachines, laundry technologies, laundry\nproducts, fabrics and the correction of\nproblems of production or avoid these.\nWe are regularly Selling: denim processing, garment processing, dyeing technologies, industrial laundry machines, jean processing, laundry support, laundry technologies, washing machines, washing technologies.\nWe are regularly Buying: textile technologies, textile ideas, washing_gr, washing, washing_gryahoocom.", "domain": "chemistry", "round": 3} +{"url": "https://777affiliates.xyz/radiocarbon-dating-practice-problems.html", "date": "2019-04-22T10:07:16Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-18/segments/1555578551739.43/warc/CC-MAIN-20190422095521-20190422121120-00073.warc.gz", "language_score": 0.9037060141563416, "token_count": 741, "dump": "CC-MAIN-2019-18", "global_id": "webtext-fineweb__CC-MAIN-2019-18__0__101616818", "lang": "en", "text": "Dating a Fossil - Carbon dating compares the ratio of carbon-12 to carbon-14 atoms in an. Carbon 14 dating is used up to be carried out. Docx transformations of the category general dating rules absolute and ions practice problems radiometric. Dec 2018. But radiocarbon dating practice problems practice, most diabetics overcompensate a tiny bit, and radiocarbon dating practice problems radicoarbon a lot of time with slightly.\nBut it is already clear that the carbon method of dating will have to be. For example, the age of the Amitsoq gneisses from western Greenland was determined to be.\nBefore long, they hit a problem. Problems. I Chi Spreadsheet. Technical Supplement 6A: How Much Isotope Should I. Another problem with radiocarbon dating is that it was assumed until the.\nOnline dating no registration\nRadiocarbon dating. Dating sample radiocarbon dating practice problems, like any charcoal or daughter isotope how much will have an example of.\nRadioactive dating indicates that the Earth is over 4 billion years old. Radiometric dating or radioactive dating is a technique used to date materials such as rocks or. Problem 1- Calculate the amount ofC remaining in a sample.\nNov 2018. Our main q a radioactive decay of absolute dating. Resource id: a reset. When dating calculator. May 1990. Please send reports of such problems to firstname.lastname@example.org.\nRadiometric dating is relatively cheap (about $300/sample), takes about a month. Half-Life and practice problems. May 2002. for Maya ritual practice, Belize. Radiocarbon dating can radiocarbon dating practice problems used on samples of bone, cloth, wood and plant fibers.\nThis brings to light a number of methodological problems, but also attests to the. Carbon-14 measurements from stalagmites takes radiocarbon dating practice problems dating back as far as it can go.\nMaterials that originally came from living things, such as wood and natural fibres, can radiocarbon dating practice problems dated by measuring the amount of carbon-14 they contain. Radioxarbon 9 Practice problems: Try the problems out, then check your answer below.\nTechnically, what this date means is that the sample is 1,445 years old, give or take. Learn about radioactive dating practice problems met.\nPrwctice dating: some problems and potential developments. Join and search! Is the number one. Its a cultural movement. Welcome to #swipelife. Two Chinese Stalagmites Are a Holy Grail for Accurate Radiocarbon Dating (gizmodo.com).\nDating exs brother\nHolocene, there is a further problem. Part of the problem is that it isnt easy to date cave art. Gospel book, considered the oldest known Ethiopian manuscript radiocarbon dating practice problems dating, see J. Radiocarbon dating is a method for determining the age of an object containing organic. Radiometric dating practice problems - Join the leader in relations services and find a date today. A fi rm program of radiocarbon dating for the radiocarbon dating practice problems rst time provides a sound time-frame.\nCarbon-14 has a relatively short half-life of 5,730 years, meaning that the fraction of carbon-14 in a sample is. Half life and radiometric dating practice problems answer key - Register and search over 40 gun safe hookup singles: voice recordings.\nChapter 9 practice problems. Although we will explore the 1940s dr.", "domain": "chemistry", "round": 3} +{"url": "https://www.ajol.info/index.php/ajtcam/article/view/143442", "date": "2023-12-03T18:07:07Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100508.42/warc/CC-MAIN-20231203161435-20231203191435-00719.warc.gz", "language_score": 0.9403836727142334, "token_count": 439, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__109785640", "lang": "en", "text": "Main Article Content\nBackground: Smoke inhalation injury refers to airway and lung parenchyma injury and general chemical damage caused by inhaling toxic gases and substances. The aim of this study was to explore the oxidative stress mechanism of cotton smoke inhalation-induced pulmonary injury in a rat model.\nMaterials and Methods: Eighteen male Sprague-Dawley rats were randomly divided into control group, 6 h group, and 24 h group (six rats in each group), which duplicated previous rat cotton smoke-inhalation injury models. Rats in 6 h and 24 h groups were euthanised at 6 h and 24 h after smoke inhalation, respectively. ELISA method was used to detect indicators in the rats’ lung tissue. Quantitative iNOS mRNA and γ-GCS mRNA measurements were performed using a fluorescence PCR method.\nResults: The concentrations of MDA, NO, iNOS, γ-GCS, iNOS mRNA, and the relative expression of γ-GCS mRNA in the rats’ lung tissues in 6 h and 24 h groups were higher than control group (P < 0.05), and the concentration of NO and relative expressions of iNOS mRNA and γ-GCS mRNA in 24 h group were significantly higher than 6 h group (P < 0.05). The concentrations of GSH in 24 h and 6 h groups were significantly lower than control group (P < 0.05), and that in 24 h group was even significantly lower than 6 h group (P < 0.05).\nConclusion: In rats with cotton smoke inhalation-induced pulmonary injury, the increased iNOS mRNA transcription can cause increase of iNOS synthesis and promotion of NO synthesis. The increased γ-GCS mRNA transcription can cause increase of γ-GCS synthesis and but decrease of GSH concentration. The activation of the antioxidant system is insufficient to combat oxidative stress damage. So the oxidant/antioxidant system is imbalanced, leading to gradual aggravation of lung injury.\nKeywords: Acute lung injury, Smoke inhalation injury, Oxidative stress", "domain": "chemistry", "round": 3} +{"url": "http://eprints.nottingham.ac.uk/34239/", "date": "2017-04-24T01:41:00Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-17/segments/1492917118950.30/warc/CC-MAIN-20170423031158-00479-ip-10-145-167-34.ec2.internal.warc.gz", "language_score": 0.8691068291664124, "token_count": 345, "dump": "CC-MAIN-2017-17", "global_id": "webtext-fineweb__CC-MAIN-2017-17__0__37520768", "lang": "en", "text": "Plasma membrane dynamics and tetrameric organisation of ABCG2 transporters in mammalian cells revealed by single particle imaging techniques\nWong, Kelvin and Briddon, Stephen J. and Holliday, Nicholas D. and Kerr, Ian D. (2016) Plasma membrane dynamics and tetrameric organisation of ABCG2 transporters in mammalian cells revealed by single particle imaging techniques. Biochimica et Biophysica Acta - Molecular Cell Research, 1863 (1). pp. 19-29. ISSN 0006-3002\nABCG2 is one of three human ATP binding cassette (ABC) transporters involved in the export from cells of a chemically and structurally diverse range of compounds. This multidrug efflux capability, together with a broad tissue distribution in the body, means that ABCG2 exerts a range of effects on normal physiology such as kidney urate transport, as well as contributing towards the pharmacokinetic profiles of many exogenous drugs. The primary sequence of ABCG2 contains only half the number of domains required for a functioning ABC transporter and so it must oligomerise in order to function, yet its oligomeric state in intact cell membranes remains uncharacterized. We have analysed ABCG2 in living cell membranes using a combination of fluorescence correlation spectroscopy, photon counting histogram analysis, and stepwise photobleaching to demonstrate a predominantly tetrameric structure for ABCG2 in the presence or absence of transport substrates. These results provide the essential basis for exploring pharmacological manipulation of oligomeric state as a strategy to modulate ABCG2 activity in future selective therapeutics.\nActions (Archive Staff Only)", "domain": "chemistry", "round": 3} +{"url": "https://www.biochemie.abi.med.uni-muenchen.de/publications/article/pub_2002_013.html", "date": "2024-04-22T13:52:30Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712296818293.64/warc/CC-MAIN-20240422113340-20240422143340-00219.warc.gz", "language_score": 0.8511756658554077, "token_count": 308, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__186431508", "lang": "en", "text": "A γ-secretase inhibitor blocks Notch signaling in vivo and causes a severe neurogenic phenotype in zebrafish\nEMBO Rep 3(7): 688-94\n|Type of Publication:\nInhibition of amyloid β-peptide (Aβ) production by blocking γ-secretase activity is at present one of the most promising therapeutic strategies to slow progression of Alzheimer's disease pathology. γ-Secretase inhibitors apparently block Aβ generation via interference with presenilin (PS) function. Besides being an essential component of the γ-secretase complex, PS itself may be an aspartyl protease with γ-secretase activity, which is not only required for Aβ production but also for a similar proteolytic process involved in Notch signaling. Here we demonstrate that treatment of zebrafish embryos with a known γ-secretase inhibitor affects embryonic development in a manner indistinguishable from Notch signaling deficiencies at morphological, molecular and biochemical levels. This indicates severe side-effects of γ-secretase inhibitors in any Notch-dependent cell fate decision and demonstrates that the zebrafish is an ideal vertebrate system to validate compounds that selectively affect Aβ production, but not Notch signaling, under in vivo conditions.", "domain": "chemistry", "round": 3} +{"url": "http://mssm.edu/profiles/jian-jin", "date": "2016-08-30T18:48:00Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2016-36/segments/1471983001995.81/warc/CC-MAIN-20160823201001-00195-ip-10-153-172-175.ec2.internal.warc.gz", "language_score": 0.6836885213851929, "token_count": 4316, "dump": "CC-MAIN-2016-36", "global_id": "webtext-fineweb__CC-MAIN-2016-36__0__18723611", "lang": "en", "text": "Jian Jin, PhD\n- PROFESSOR | Oncological Sciences\n- PROFESSOR | Pharmacological Sciences\nResearch Topics:Cancer, Chromatin, Drug Design and Discovery, Membrane Proteins/Channels, Schizophrenia\nDr. Jian Jin received a B.S. degree in chemistry from University of Science and Technology of China in 1991 and a Ph.D. degree in organic chemistry from the Pennsylvania State University in 1997. After completing a postdoctoral training at the Ohio State University, Dr. Jin joined GlaxoSmithKline as a medicinal chemist in 1998 and had been a manager of medicinal chemistry from 2003 to 2008. In 2008, Dr. Jin joined the Division of Chemical Biology and Medicinal Chemistry at the University of North Carolina at Chapel Hill (UNC – CH) as an Associate Professor. He had also served as an Associate Director of medicinal chemistry in the Center for Integrative Chemical Biology and Drug Discovery at UNC – CH from 2008 to 2014. In 2014, Dr. Jin was recruited to the Icahn School of Medicine at Mount Sinai (Mount Sinai) as a Professor with Tenure. He is currently a Professor in Department of Pharmacological Sciences and a Professor in Department of Oncological Sciences. Since 2008, Dr. Jin’s laboratory has focused on discovering selective inhibitors of histone methyltransferases and functionally selective ligands of G protein-coupled receptors. To date, Dr. Jin has published more than 100 research papers and delivered more than 70 invited talks. He is also an inventor of 10 issued U.S. patents and 37 published PCT patent applications.\nComplete list of published work in PubMed\nGoogle scholar citations\nMulti-Disciplinary Training AreaBiophysics and Systems Pharmacology [BSP]\nBS, University of Science and Technology of China\nPhD, Pennsylvania State University\nPostdoc, Ohio State University\nDiscovery of Selective Inhibitors for Histone Methyltransferases\nPost-translational modifications (PTMs) of histones play a critical role in diverse biological processes including chromatin compaction, gene expression, transcriptional regulation, and cell differentiation. Among a myriad of PTMs, histone methylation catalyzed by histone methyltransferases (HMTs) has been increasingly recognized as a major signaling mechanism in eukaryotic cells. HMTs are divided into two categories: lysine methyltransferases (PKMTs) and arginine methyltransferases (PRMTs), More than 50 PKMTs and 9 PRMTs have been identified. Mounting evidence suggests that HMTs play crucial roles in various human diseases. To create high quality selective inhibitors of HMTs, the Jin lab has taken a systematic approach by targeting the HMT substrate binding groove, cofactor binding site, and potential allosteric binding site(s).\nDiscovery of Functionally Selective Ligands of GPCRs\nG protein-coupled receptors (GPCRs) signal not only via canonical pathways involving heterotrimeric large G proteins, but also via non-canonical G protein-independent interactions with other signaling proteins including beta-arrestins. The process by which GPCR ligands differentially modulate canonical and non-canonical signal transduction pathways is a phenomenon known as “functional selectivity” (also knows as signaling bias). Such functionally selective ligands (also known as biased ligands) preferentially engage either canonical or non-canonical GPCR pathways. The discovery of ligands with discrete functional selectivity profiles will be extremely useful for elucidating the key signal transduction pathways essential for both the therapeutic actions and side-effects of drugs. The Jin lab has been actively engaged in generating functionally selective ligands of GPCRs.\nLiu F, Chen X, Allali-Hassani A, Quinn AM, Wasney GA, Dong A, Barsyte D, Kozieradzki I, Senisterra G, Chau I, Siarheyeva A, Kireev DB, Jadhav A, Herold JM, Frye SV, Arrowsmith CH, Brown PJ, Simeonov A, Vedadi M, Jin J. Discovery of a 2,4-diamino-7-aminoalkoxyquinazoline as a potent and selective inhibitor of histone lysine methyltransferase G9a. Journal of medicinal chemistry 2009 Dec; 52(24).\nJohnson SM, Torrice CD, Bell JF, Monahan KB, Jiang Q, Wang Y, Ramsey MR, Jin J, Wong KK, Su L, Zhou D, Sharpless NE. Mitigation of hematologic radiation toxicity in mice through pharmacological quiescence induced by CDK4/6 inhibition. The Journal of clinical investigation 2010 Jul; 120(7).\nLiu F, Chen X, Allali-Hassani A, Quinn AM, Wigle TJ, Wasney GA, Dong A, Senisterra G, Chau I, Siarheyeva A, Norris JL, Kireev DB, Jadhav A, Herold JM, Janzen WP, Arrowsmith CH, Frye SV, Brown PJ, Simeonov A, Vedadi M, Jin J. Protein lysine methyltransferase G9a inhibitors: design, synthesis, and structure activity relationships of 2,4-diamino-7-aminoalkoxy-quinazolines. Journal of medicinal chemistry 2010 Aug; 53(15).\nVedadi M, Barsyte-Lovejoy D, Liu F, Rival-Gervier S, Allali-Hassani A, Labrie V, Wigle TJ, Dimaggio PA, Wasney GA, Siarheyeva A, Dong A, Tempel W, Wang SC, Chen X, Chau I, Mangano TJ, Huang XP, Simpson CD, Pattenden SG, Norris JL, Kireev DB, Tripathy A, Edwards A, Roth BL, Janzen WP, Garcia BA, Petronis A, Ellis J, Brown PJ, Frye SV, Arrowsmith CH, Jin J. A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells. Nature chemical biology 2011 Aug; 7(8).\nLiu F, Barsyte-Lovejoy D, Allali-Hassani A, He Y, Herold JM, Chen X, Yates CM, Frye SV, Brown PJ, Huang J, Vedadi M, Arrowsmith CH, Jin J. Optimization of cellular activity of G9a inhibitors 7-aminoalkoxy-quinazolines. Journal of medicinal chemistry 2011 Sep; 54(17).\nAllen JA, Yost JM, Setola V, Chen X, Sassano MF, Chen M, Peterson S, Yadav PN, Huang XP, Feng B, Jensen NH, Che X, Bai X, Frye SV, Wetsel WC, Caron MG, Javitch JA, Roth BL, Jin J. Discovery of β-arrestin-biased dopamine D2 ligands for probing signal transduction pathways essential for antipsychotic efficacy. Proceedings of the National Academy of Sciences of the United States of America 2011 Nov; 108(45).\nHuang HS, Allen JA, Mabb AM, King IF, Miriyala J, Taylor-Blake B, Sciaky N, Dutton JW, Lee HM, Chen X, Jin J, Bridges AS, Zylka MJ, Roth BL, Philpot BD. Topoisomerase inhibitors unsilence the dormant allele of Ube3a in neurons. Nature 2012 Jan; 481(7380).\nDuncan JS, Whittle MC, Nakamura K, Abell AN, Midland AA, Zawistowski JS, Johnson NL, Granger DA, Jordan NV, Darr DB, Usary J, Kuan PF, Smalley DM, Major B, He X, Hoadley KA, Zhou B, Sharpless NE, Perou CM, Kim WY, Gomez SM, Chen X, Jin J, Frye SV, Earp HS, Graves LM, Johnson GL. Dynamic reprogramming of the kinome in response to targeted MEK inhibition in triple-negative breast cancer. Cell 2012 Apr; 149(2).\nSiarheyeva A, Senisterra G, Allali-Hassani A, Dong A, Dobrovetsky E, Wasney GA, Chau I, Marcellus R, Hajian T, Liu F, Korboukh I, Smil D, Bolshan Y, Min J, Wu H, Zeng H, Loppnau P, Poda G, Griffin C, Aman A, Brown PJ, Jin J, Al-Awar R, Arrowsmith CH, Schapira M, Vedadi M. An allosteric inhibitor of protein arginine methyltransferase 3. Structure (London, England : 1993) 2012 Aug; 20(8).\nKorboukh I, Hull-Ryde EA, Rittiner JE, Randhawa AS, Coleman J, Fitzpatrick BJ, Setola V, Janzen WP, Frye SV, Zylka MJ, Jin J. Orally active adenosine A(1) receptor agonists with antinociceptive effects in mice. Journal of medicinal chemistry 2012 Jul; 55(14).\nChen X, Sassano MF, Zheng L, Setola V, Chen M, Bai X, Frye SV, Wetsel WC, Roth BL, Jin J. Structure-functional selectivity relationship studies of β-arrestin-biased dopamine D₂ receptor agonists. Journal of medicinal chemistry 2012 Aug; 55(16).\nJames LI, Barsyte-Lovejoy D, Zhong N, Krichevsky L, Korboukh VK, Herold JM, MacNevin CJ, Norris JL, Sagum CA, Tempel W, Marcon E, Guo H, Gao C, Huang XP, Duan S, Emili A, Greenblatt JF, Kireev DB, Jin J, Janzen WP, Brown PJ, Bedford MT, Arrowsmith CH, Frye SV. Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain. Nature chemical biology 2013 Mar; 9(3).\nLiu F, Li F, Ma A, Dobrovetsky E, Dong A, Gao C, Korboukh I, Liu J, Smil D, Brown PJ, Frye SV, Arrowsmith CH, Schapira M, Vedadi M, Jin J. Exploiting an allosteric binding site of PRMT3 yields potent and selective inhibitors. Journal of medicinal chemistry 2013 Mar; 56(5).\nKonze KD, Ma A, Li F, Barsyte-Lovejoy D, Parton T, Macnevin CJ, Liu F, Gao C, Huang XP, Kuznetsova E, Rougie M, Jiang A, Pattenden SG, Norris JL, James LI, Roth BL, Brown PJ, Frye SV, Arrowsmith CH, Hahn KM, Wang GG, Vedadi M, Jin J. An orally bioavailable chemical probe of the Lysine Methyltransferases EZH2 and EZH1. ACS chemical biology 2013; 8(6).\nLiu F, Barsyte-Lovejoy D, Li F, Xiong Y, Korboukh V, Huang XP, Allali-Hassani A, Janzen WP, Roth BL, Frye SV, Arrowsmith CH, Brown PJ, Vedadi M, Jin J. Discovery of an in vivo chemical probe of the lysine methyltransferases G9a and GLP. Journal of medicinal chemistry 2013 Nov; 56(21).\nZhou B, Damrauer JS, Bailey ST, Hadzic T, Jeong Y, Clark K, Fan C, Murphy L, Lee CY, Troester MA, Miller CR, Jin J, Darr D, Perou CM, Levine RL, Diehn M, Kim WY. Erythropoietin promotes breast tumorigenesis through tumor-initiating cell self-renewal. The Journal of clinical investigation 2014 Feb; 124(2).\nLehnertz B, Pabst C, Su L, Miller M, Liu F, Yi L, Zhang R, Krosl J, Yung E, Kirschner J, Rosten P, Underhill TM, Jin J, Hébert J, Sauvageau G, Humphries RK, Rossi FM. The methyltransferase G9a regulates HoxA9-dependent transcription in AML. Genes & development 2014 Feb; 28(4).\nKonze KD, Pattenden SG, Liu F, Barsyte-Lovejoy D, Li F, Simon JM, Davis IJ, Vedadi M, Jin J. A chemical tool for in vitro and in vivo precipitation of lysine methyltransferase G9a. ChemMedChem 2014 Mar; 9(3).\nWright BD, Loo L, Street SE, Ma A, Taylor-Blake B, Stashko MA, Jin J, Janzen WP, Frye SV, Zylka MJ. The lipid kinase PIP5K1C regulates pain signaling and sensitization. Neuron 2014 May; 82(4).\nSundriyal S, Malmquist NA, Caron J, Blundell S, Liu F, Chen X, Srimongkolpithak N, Jin J, Charman SA, Scherf A, Fuchter MJ. Development of diaminoquinazoline histone lysine methyltransferase inhibitors as potent blood-stage antimalarial compounds. ChemMedChem 2014 Oct; 9(10).\nMa A, Yu W, Li F, Bleich RM, Herold JM, Butler KV, Norris JL, Korboukh V, Tripathy A, Janzen WP, Arrowsmith CH, Frye SV, Vedadi M, Brown PJ, Jin J. Discovery of a selective, substrate-competitive inhibitor of the lysine methyltransferase SETD8. Journal of medicinal chemistry 2014 Aug; 57(15).\nMa A, Yu W, Xiong Y, Butler KV, Brown PJ, Jin J. Structure-activity Relationship Studies of SETD8 Inhibitors. MedChemComm 2014;: DOI: 10.1039/C4MD00317A.\nXu B, On DM, Ma A, Parton T, Konze KD, Pattenden SG, Allison DF, Cai L, Rockowitz S, Liu S, Liu Y, Li F, Vedadi M, Frye SV, Garcia BA, Zheng D, Jin J, Wang GG. Selective inhibition of EZH2 and EZH1 enzymatic activity by a small molecule suppresses MLL-rearranged leukemia. Blood 2014 Nov;.\nKaniskan HU, Jin J. Chemical Probes of Histone Lysine Methyltransferases. ACS chemical biology 2014 Nov;.\nKaniskan HU, Konze KD, Jin J. Selective Inhibitors of Protein Methyltransferases. Journal of medicinal chemistry 2014 Dec;.\nLiu C, Yu Y, Liu F, Wei X, Wrobel JA, Gunawardena HP, Zhou L, Jin J, Chen X. A chromatin activity-based chemoproteomic approach reveals a transcriptional repressome for gene-specific silencing. Nature communications 2014 Dec; 5.\nKatona BW, Liu Y, Ma A, Jin J, Hua X. EZH2 inhibition enhances the efficacy of an EGFR inhibitor in suppressing colon cancer cells. Cancer biology & therapy 2014 Dec; 15(12).\nChen X, Choo H, Huang XP, Yang X, Stone O, Roth B, Jin J. The First Structure-activity Relationship Studies for Designer Receptors Exclusively Activated by Designer Drugs (DREADDs). ACS chemical neuroscience 2015 Jan;.\nKaniskan HU, Szewczyk MM, Yu Z, Eram MS, Yang X, Schmidt K, Luo X, Dai M, He F, Zang I, Lin Y, Kennedy S, Li F, Dobrovetsky E, Dong A, Smil D, Min SJ, Landon M, Lin-Jones J, Huang XP, Roth BL, Schapira M, Atadja P, Barsyte-Lovejoy D, Arrowsmith CH, Brown PJ, Zhao K, Jin J, Vedadi M. A Potent, Selective and Cell-Active Allosteric Inhibitor of Protein Arginine Methyltransferase 3 (PRMT3). Angewandte Chemie (International ed. in English) 2015 Feb;.\nStuhlmiller TJ, Miller SM, Zawistowski JS, Nakamura K, Beltran AS, Duncan JS, Angus SP, Collins KA, Granger DA, Reuther RA, Graves LM, Gomez SM, Kuan PF, Parker JS, Chen X, Sciaky N, Carey LA, Earp HS, Jin J, Johnson GL. Inhibition of Lapatinib-Induced Kinome Reprogramming in ERBB2-Positive Breast Cancer by Targeting BET Family Bromodomains. Cell reports 2015 Apr; 11(3).\nAbou El Hassan M, Huang K, Eswara MB, Zhao M, Song L, Yu T, Liu Y, Liu JC, McCurdy S, Ma A, Wither J, Jin J, Zacksenhaus E, Wrana JL, Bremner R. Cancer Cells Hijack PRC2 to Modify Multiple Cytokine Pathways. PloS one 2015; 10(6).\nXu B, Konze KD, Jin J, Wang GG. Targeting EZH2 and PRC2 dependence as novel anticancer therapy. Experimental hematology 2015 Aug; 43(8).\nWang L, Xie L, Ramachandran S, Lee Y, Yan Z, Zhou L, Krajewski K, Liu F, Zhu C, Chen DJ, Strahl BD, Jin J, Dokholyan NV, Chen X. Non-canonical Bromodomain within DNA-PKcs Promotes DNA Damage Response and Radioresistance through Recognizing an IR-Induced Acetyl-Lysine on H2AX. Chemistry & biology 2015 Jul; 22(7).\nPark SM, Chen M, Schmerberg CM, Dulman RS, Rodriguiz RM, Caron MG, Jin J, Wetsel WC. Effects of β-Arrestin-Biased Dopamine D2 Receptor Ligands on Schizophrenia-Like Behavior in Hypoglutamatergic Mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2015 Jul;.\nArrowsmith CH, Audia JE, Austin C, Baell J, Bennett J, Blagg J, Bountra C, Brennan PE, Brown PJ, Bunnage ME, Buser-Doepner C, Campbell RM, Carter AJ, Cohen P, Copeland RA, Cravatt B, Dahlin JL, Dhanak D, Edwards AM, Frye SV, Gray N, Grimshaw CE, Hepworth D, Howe T, Huber KV, Jin J, Knapp S, Kotz JD, Kruger RG, Lowe D, Mader MM, Marsden B, Mueller-Fahrnow A, Müller S, O'Hagan RC, Overington JP, Owen DR, Rosenberg SH, Roth B, Ross R, Schapira M, Schreiber SL, Shoichet B, Sundström M, Superti-Furga G, Taunton J, Toledo-Sherman L, Walpole C, Walters MA, Willson TM, Workman P, Young RN, Zuercher WJ. The promise and peril of chemical probes. Nature chemical biology 2015 Jul; 11(8).\nSimon JM, Parker JS, Liu F, Rothbart SB, Ait-Si-Ali S, Strahl BD, Jin J, Davis IJ, Mosley AL, Pattenden SG. A Role for Widely Interspaced Zinc Finger (WIZ) in Retention of the G9a Methyltransferase on Chromatin. The Journal of biological chemistry 2015 Sep;.", "domain": "chemistry", "round": 3} +{"url": "https://www.semanticscholar.org/topic/Methylophaga/1302292", "date": "2021-10-21T22:39:17Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-43/segments/1634323585441.99/warc/CC-MAIN-20211021195527-20211021225527-00139.warc.gz", "language_score": 0.9024786353111267, "token_count": 286, "dump": "CC-MAIN-2021-43", "global_id": "webtext-fineweb__CC-MAIN-2021-43__0__239068506", "lang": "en", "text": "Semantic Scholar uses AI to extract papers important to this topic.\nBackground The biofilm of a methanol-fed, fluidized denitrification system treating a marine effluent is composed of multi… Expand Which bacterial taxonomic groups can be used in monitoring saline water methanol-utilizing denitrification and whether nitrate is… Expand Marine hydrocarbon-degrading bacteria perform a fundamental role in the oxidation and ultimate removal of crude oil and its… Expand ABSTRACT Methylophaga sp. strains JAM1 and JAM7 have been isolated from a denitrification system. Strain JAM1 was the first… Expand Methylophaga spp. are methylotrophs commonly associated with marine environments and have been defined as strict aerobic… Expand ABSTRACT Dimethylsulfide (DMS)-degrading enrichment cultures were established from samples of coastal seawater, nonaxenic… Expand Methylophaga sp. strain SK1 is a new restricted facultative methanol-oxidizing bacterium that was isolated from seawater. The aim… Expand Methylotrophic bacteria are widespread in nature. They may play an important role in the cycling of carbon and in the metabolism… Expand The genus Methylophaga with two species, M. marina and M. thalassica, comprises halophilic methylotrophic bacteria. These… Expand", "domain": "chemistry", "round": 3} +{"url": "https://www.inctrl.com/northwestern-university-and-inctrl-begin-bioprocess-modeling-collaboration/", "date": "2022-08-07T19:30:11Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882570692.22/warc/CC-MAIN-20220807181008-20220807211008-00031.warc.gz", "language_score": 0.8803877234458923, "token_count": 325, "dump": "CC-MAIN-2022-33", "global_id": "webtext-fineweb__CC-MAIN-2022-33__0__42009465", "lang": "en", "text": "The research group of George Wells at Northwestern University is conducting a bench-scale investigation of shortcut biological nitrogen removal (scBNR) processes integrated with enhanced biological phosphorus removal (EBPR) and has teamed up with inCTRL Solutions to model these processes and perform predictive scenario evaluation in the SIMBA# simulation platform. Water resource recovery facilities are under increasing pressure to remove nitrogen and phosphorus while minimizing costs and greenhouse gas emissions. scBNR processes, which rely on the suppression of nitrite oxidizing bacteria (NOB), decrease aeration requirements considerably compared to conventional nitrification/dentrification and allow for maximum allocation of organic carbon either to phosphorus accumulating organisms (PAO) or to the plant’s sludge handling stream. scBNR is thus regarded as a crucial technology to allow for low-energy nitrogen and phosphorus removal.\nRobust bioprocess modeling aided by SIMBA# will add an additional layer of very useful process information to complement experiment data. The experimental reactors are equipped with online sensors and a PLC/SCADA system for sensor-based control strategy evaluation. SIMBA# is uniquely suited to model sensor-based control strategies and the allied Monitoring and Control Platform have substantial capabilities to detect sensor malfunctions. The experimental bioprocesses in this study employ a variety of biomass aggregate types ((moving bed biofilm carriers, granules, and flocs) which are effectively handled by the biofilm and suspended growth reactor models in SIMBA#. SIMBA# will be an incredibly useful tool and inCTRL Solutions is proving to be an exceptional partner in this research effort.", "domain": "chemistry", "round": 3} +{"url": "https://phiab.com/publications/immunomodulatory-nanoparticles-as-adjuvants-and-allergen-delivery-system-to-human-dendritic-cells-implications-for-specific-immunotherapy/", "date": "2023-10-02T08:31:17Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233510983.45/warc/CC-MAIN-20231002064957-20231002094957-00434.warc.gz", "language_score": 0.8506902456283569, "token_count": 272, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__305140481", "lang": "en", "text": "Immunomodulatory Nanoparticles as Adjuvants and Allergen-delivery System to Human Dendritic Cells: Implications for Specific Immunotherapy\nJournal: Vaccine (2010)\nInstitution: Lund University\nResearch Areas: Immunology\nCell Lines: MoDC (Monocyte-derived dendritic cell)\nSummary: Novel adjuvants and antigen-delivery systems with immunomodulatory properties that shift the allergenic Th2 response towards a Th1 or regulatory T cell response are desired for allergen-specific immunotherapy. This study demonstrates that 200-nm sized biodegradable poly(γ-glutamic acid) (γ-PGA) nanoparticles (NPs) are activators of human monocyte-derived dendritic cells (MoDCs). γ-PGA NPs are efficiently internalized by immature MoDCs and strongly stimulate the production of chemokines and inflammatory cytokines as well as up-regulation of co-stimulatory molecules and immunomodulatory mediators involved inefficient T cell priming. The study suggests γ-PGA NPs are promising as sophisticated adjuvants and allergen-delivery systems in allergen-specific immunotherapy. HoloMonitor M2 was used to study cell morphology.", "domain": "chemistry", "round": 3} +{"url": "https://www.astm.org/DATABASE.CART/HISTORICAL/D1070-03.htm", "date": "2020-08-15T14:19:35Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-34/segments/1596439740848.39/warc/CC-MAIN-20200815124541-20200815154541-00537.warc.gz", "language_score": 0.8735456466674805, "token_count": 435, "dump": "CC-MAIN-2020-34", "global_id": "webtext-fineweb__CC-MAIN-2020-34__0__106100103", "lang": "en", "text": "SUPERSEDED (click for Active standard)\n| ||Format||Pages||Price|| |\n|8||$60.00||  ADD TO CART|\n1.1 These test methods cover the determination of relative density of gaseous fuels, including liquefied petroleum gases, in the gaseous state at normal temperatures and pressures. The test methods specified are sufficiently varied in nature so that one or more may be used for laboratory, control, reference, gas measurement, or in fact, for any purpose in which it is desired to know the relative density of gas or gases as compared to the density of dry air at the same temperature and pressure.\n1.2 The procedures appear in the following sections:\n|Method A, Ac-Me Gravity Balance||7-9|\n|Method B, Ranarex Recording and Indicating Gravitometer||10-11|\n|Method C, UGC Gravitometer||12-14|\nNote 1—The test methods and apparatus described herein are representative of methods and apparatus used broadly in industry. Manufacturer's instructions for specific models should be consulted for further details and as supplements to the information presented here. In addition to instrumentation described below additional equally accurate and satisfactory instruments may be available.\n1.3 This standard does not purport to address all of the safety concerns, if any, associated with its use. It is the responsibility of the user of this standard to establish appropriate safety and health practices and determine the applicability of regulatory limitations prior to use.\n2. Referenced Documents (purchase separately) The documents listed below are referenced within the subject standard but are not provided as part of the standard.\nD5503 Practice for Natural Gas Sample-Handling and Conditioning Systems for Pipeline Instrumentation\n|Link to Active (This link will always route to the current Active version of the standard.)|\nASTM D1070-03, Standard Test Methods for Relative Density of Gaseous Fuels, ASTM International, West Conshohocken, PA, 2003, www.astm.orgBack to Top", "domain": "chemistry", "round": 3} +{"url": "https://teslapowerusa.ae/benefits-of-alkaline-water.php", "date": "2023-10-04T22:28:07Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233511424.48/warc/CC-MAIN-20231004220037-20231005010037-00404.warc.gz", "language_score": 0.9067233204841614, "token_count": 555, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__101514622", "lang": "en", "text": "In recent years, the concept of alkaline water has gained significant attention due to its potential health benefits. However, what if we combine the benefits of alkaline water with the cutting-edge technology of Tesla Power MENA? In this blog, we will explore the advantages of alkaline water and how Tesla Power MENA can enhance its potential, providing a revolutionary solution for clean energy and sustainable living.\nUnderstanding Alkaline Water: Alkaline water is water that has a higher pH level, typically above 7, which makes it less acidic than regular tap water. It is believed that consuming alkaline water can help neutralize acid in the body, support better hydration, and promote overall well-being. The potential benefits of alkaline water include improved digestion, enhanced detoxification, increased energy levels, and even anti-aging properties.\nTesla Power MENA; Revolutionizing Energy: Tesla Power MENA is a groundbreaking initiative focused on utilizing renewable energy sources to meet the region's power demands. With their advanced solar technology and energy storage solutions, Tesla Power MENA aims to reduce carbon emissions and provide a sustainable energy infrastructure. By harnessing the power of the sun, they provide accessible and reliable energy solutions while minimizing reliance on fossil fuels.\nThe Synergy of Alkaline Water and Tesla Power MENA: Combining the benefits of alkaline water with Tesla Power MENA's innovative technology opens up new possibilities for sustainable living. Tesla Power MENA's solar energy systems can power water ionizers, which are devices that convert regular tap water into alkaline water. This not only ensures a constant supply of alkaline water but also reduces the reliance on traditional electrical sources.\nMoreover, Tesla Power MENA's energy storage solutions enable homeowners and businesses to store excess solar energy for later use, including powering alkaline water ionizers. This means that even during cloudy days or nighttime, alkaline water production can continue without interruption. The integration of alkaline water production with renewable energy sources contributes to a more eco-friendly lifestyle, reducing carbon footprints and promoting sustainability.\nEnvironmental and Health Benefits: By utilizing Tesla Power MENA's renewable energy solutions for alkaline water production, we can reap both environmental and health benefits. The reduction in carbon emissions and reliance on fossil fuels helps combat climate change and protect our planet. Meanwhile, the consumption of alkaline water can support optimal hydration, promote detoxification, and boost overall well-being.\nIncorporating Tesla Power MENA's renewable energy solutions with alkaline water production offers a powerful combination. It not only enhances the health benefits of alkaline water but also contributes to a sustainable and eco-friendly lifestyle. By embracing this synergy, we can pave the way for a cleaner and healthier future for all.", "domain": "chemistry", "round": 3} +{"url": "https://pure.qub.ac.uk/en/publications/characterization-and-kinetic-modeling-for-pyrolytic-conversion-of", "date": "2023-06-02T09:48:49Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-23/segments/1685224648465.70/warc/CC-MAIN-20230602072202-20230602102202-00187.warc.gz", "language_score": 0.8342402577400208, "token_count": 562, "dump": "CC-MAIN-2023-23", "global_id": "webtext-fineweb__CC-MAIN-2023-23__0__142776526", "lang": "en", "text": "Herein, cotton stalk biomass was initially characterized to understand its physicochemical properties as a raw material for biochar production. Furthermore, thermal analysis was conducted using thermogravimetric analysis (TGA), and the results were further utilized to evaluate the cotton stalk's kinetic behavior under thermal decomposition in an inert environment. Advanced kinetics and technology solutions (AKTS) software was for the first time employed to compute the kinetic parameters of cotton stalk pyrolysis, as well as provide kinetic predictions under isothermal conditions. Three methods were used to compute the activation energy (Ea) value, namely ASTM-E698, Flynn-Wall-Ozawa (FWO), and Friedman's differential iso-conversional model. The results obtained using the ASTM-E698 method indicate an activation energy of 127.23 kJ·mol−1. Furthermore, the FWO method presented an Ea value ranging 35-250 kJ·mol−1. The differential iso-conversional method is the most robust approach as it adequately represents the complex nature of lignocellulosic biomass decomposition, showing an Ea range between 4 and 250 kJ·mol−1. Based on the differential iso-conversional method, kinetic predictions under isothermal conditions were provided. The predictions offer valuable insight for industrial-scale biochar project developers in relation to production throughput optimization. Furthermore, the kinetic parameters obtained can be utilized in process modeling.\n|Journal||Energy Science & Engineering|\n|Early online date||15 Aug 2021|\n|Publication status||Early online date - 15 Aug 2021|\n- Cotton stalk\n- Biomass feedstock\n- Kinetic modelling\n- Climate change mitigation\n- kinetic model\nFingerprintDive into the research topics of 'Characterization and kinetic modeling for pyrolytic conversion of cotton stalks'. Together they form a unique fingerprint.\nAtmospheric carbon removal via industrial biochar systems: A techno-economic-environmental assessmentAuthor: Fawzy, S., Jul 2023\nSupervisor: Rooney, D. (Supervisor) & Wu, C. (Supervisor)\nStudent thesis: Doctoral Thesis › Doctor of PhilosophyFile\nPhysicochemical characterisation, kinetic investigation and process modelling of the thermal decomposition of polymers found in end of life first-generation PV modulesAuthor: Farrell, C., Jul 2023\nSupervisor: Murphy, A. (Supervisor) & Doherty, R. (Supervisor)\nStudent thesis: Doctoral Thesis › Doctor of Philosophy", "domain": "chemistry", "round": 3} +{"url": "https://adcr.ru/en/2020-2-5/", "date": "2021-01-17T06:43:58Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-04/segments/1610703509973.34/warc/CC-MAIN-20210117051021-20210117081021-00192.warc.gz", "language_score": 0.814372718334198, "token_count": 416, "dump": "CC-MAIN-2021-04", "global_id": "webtext-fineweb__CC-MAIN-2021-04__0__92296546", "lang": "en", "text": "ON THE REUSE OF POLYCATIONIC DRILLING FLUIDS WHEN DRILLING WELLS AT THE ASTRAKHAN GAS CONDENSATE FIELD\nKhubbatov A.A. – Candidate of Technical Sciences, Deputy Head of the Laboratory, Gazprom VNIIGAZ LLC, A_Khubbatov@vniigaz.gazprom.ru\nGaidarov A.M. – Junior Researcher, Gazprom VNIIGAZ LLC,\nKhrabrov D.V. – Junior Researcher, Laboratory for Well Construction Technologies Development,\nGaidarov M.M-R. – Doctor of Technical Sciences, Head of the Laboratory for Development of Process Fluids for Drilling and Well Workover, Gazprom VNIIGAZ LLC,\nKey words: polycationic drilling fluids, drilling fluid operating time, disposal, reuse, Astrakhan gas condensate field.\nIn the process of drilling wells, an excess volume of drilling fluid accumulates, which must be disposed of and creates a potential threat to the environment.\nThe determining factor affecting the accumulation of excess fluid volume and, therefore, posing a threat to the environment, is the properties of the drilling fluid. Firstly, the drilling fluid must be environmentally friendly, secondly, it must have high inhibiting and anchorage properties that ensure the stability of the fluid, and thirdly, it must reduce the utilization of the volume of fluid, which is achieved by creating reusable drilling fluids.\nOn the example of the Astrakhan gas condensate field, the problem of minimizing the utilized volumes of drilling fluid is considered. Drilling of wells at the Astrakhan gas condensate field is carried out using polycationic drilling fluids, which prevent production, reduce drilling waste and minimize complications.\nIn order to prevent the disposal of drilling fluids and reduce the environmental burden on the environment, it is recommended to increase the capacity of the tank farm for storing and reusing polycationic drilling fluids.", "domain": "chemistry", "round": 3} +{"url": "http://www.abcam.com/PLK1-phospho-T210-antibody-2A3-ab39068.html", "date": "2013-12-11T00:25:44Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2013-48/segments/1386164027414/warc/CC-MAIN-20131204133347-00003-ip-10-33-133-15.ec2.internal.warc.gz", "language_score": 0.8281563520431519, "token_count": 1464, "dump": "CC-MAIN-2013-48", "global_id": "webtext-fineweb__CC-MAIN-2013-48__0__148743550", "lang": "en", "text": "Anti-PLK1 (phospho T210) antibody [2A3] (ab39068)\n- Product nameAnti-PLK1 (phospho T210) antibody [2A3]See all PLK1 primary antibodies ...\n- DescriptionMouse monoclonal [2A3] to PLK1 (phospho T210)\n- Specificityab39068 recognises Plk1 (phospho T210).\n- Tested applicationsICC/IF, Flow Cyt, WB more details\n- Species reactivityReacts with: Chicken, Human\nSynthetic peptide (Human): Modified peptide\n- Positive control\n- Extracts from overnight nocodazole treated Hela cells.\n- Storage instructionsStore at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.\n- Storage bufferPreservative: 0.09% Sodium Azide\nConstituents: PBS, pH 7.2\n- Concentration information loading...\n- PurityProtein G purified\n- Purification notesab39068 is an affinity purified IgG.\n- Clonality Monoclonal\n- Clone number2A3\n- Light chain typekappa\n- Research Areas\nOur Abpromise guarantee covers the use of ab39068 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\nWB: Use at a concentration of 1 µg/ml. Predicted molecular weight: 68 kDa.\nNot yet tested in other applications.\nOptimal dilutions/concentrations should be determined by the end user.\n- FunctionSerine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of APC/C inhibitors, and the regulation of mitotic exit and cytokinesis. Required for recovery after DNA damage checkpoint and entry into mitosis. Required for kinetochore localization of BUB1B. Phosphorylates SGOL1. Required for spindle pole localization of isoform 3 of SGOL1 and plays a role in regulating its centriole cohesion function. Phosphorylates BORA, and thereby promotes the degradation of BORA. Contributes to the regulation of AURKA function. Regulates TP53 stability through phosphorylation of TOPORS.\n- Tissue specificityPlacenta and colon.\n- Sequence similaritiesBelongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.\nContains 2 POLO box domains.\nContains 1 protein kinase domain.\n- Developmental stageAccumulates to a maximum during the G2 and M phases, declines to a nearly undetectable level following mitosis and throughout G1 phase, and then begins to accumulate again during S phase.\nmodificationsCatalytic activity is enhanced by phosphorylation of Thr-210. Phosphorylation at Thr-210 is first detected on centrosomes in the G2 phase of the cell cycle, peaks in prometaphase and gradually disappears from centrosomes during anaphase.\nAutophosphorylation and phosphorylation of Ser-137 may not be significant for the activation of PLK1 during mitosis, but may enhance catalytic activity during recovery after DNA damage checkpoint.\nUbiquitinated by the anaphase promoting complex/cyclosome (APC/C) in anaphase and following DNA damage, leading to its degradation by the proteasome. Ubiquitination is mediated via its interaction with FZR1/CDH1. Ubiquitination and subsequent degradation prevents entry into mitosis and is essential to maintain an efficient G2 DNA damage checkpoint.\n- Cellular localizationNucleus. Chromosome > centromere > kinetochore. Cytoplasm > cytoskeleton > centrosome. During early stages of mitosis, the phosphorylated form is detected on centrosomes and kinetochores. Localizes to the outer kinetochore. Presence of SGOL1 and interaction with the phosphorylated form of BUB1 is required for the kinetochore localization.\n- Cell cycle regulated protein kinase antibody\n- PLK 1 antibody\n- PLK antibody\n- PLK-1 antibody\n- plk1 antibody\n- PLK1_HUMAN antibody\n- polio like kinase antibody\n- Polo like kinase 1 antibody\n- Polo-like kinase 1 antibody\n- Serine/threonine protein kinase 13 antibody\n- Serine/threonine protein kinase PLK1 antibody\n- Serine/threonine-protein kinase 13 antibody\n- Serine/threonine-protein kinase antibody\n- Serine/threonine-protein kinase PLK1 antibody\n- STPK 13 antibody\n- STPK13 antibody\nAnti-PLK1 (phospho T210) antibody [2A3] images\nAll lanes : Anti-PLK1 (phospho T210) antibody [2A3] (ab39068) at 1 µg/ml\nLane 1 : Extracts from untreated Hela cells\nLane 2 : Extracts from overnight nocodazole treated Hela cells\nPredicted band size : 68 kDa\nObserved band size : 66 kDa (why is the actual band size different from the predicted?)\nab39068 staining chicken B lymphoma cells in prometaphase by ICC/IF. Cells were PFA fixed and permeabilized in 0.15% Triton X-100 prior to blocking in 1% BSA for 1 hour at 4°C. The primary antibody was diluted 1/300 (PBS/1%BSA) and incubated with the sample for 1 hour at 37°C. A Texas Red® conjugated goat polyclonal to mouse, diluted 1/200, was used as the secondary.\nReferences for Anti-PLK1 (phospho T210) antibody [2A3] (ab39068)\nThis product has been referenced in:\n- Tan EP et al. O-linked N-acetylglucosamine cycling regulates mitotic spindle organization. J Biol Chem 288:27085-99 (2013). Read more (PubMed: 23946484) »\n- Kasahara K et al. PI 3-kinase-dependent phosphorylation of Plk1-Ser99 promotes association with 14-3-3? and is required for metaphase-anaphase transition. Nat Commun 4:1882 (2013). Human . Read more (PubMed: 23695676) »", "domain": "chemistry", "round": 3} +{"url": "https://www.hopkinsmedicine.org/Research/research_lab_results.html?query=ATP&pagesize=10&page=1", "date": "2023-06-02T06:22:56Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-23/segments/1685224648322.84/warc/CC-MAIN-20230602040003-20230602070003-00315.warc.gz", "language_score": 0.8501987457275391, "token_count": 445, "dump": "CC-MAIN-2023-23", "global_id": "webtext-fineweb__CC-MAIN-2023-23__0__60120204", "lang": "en", "text": "Research Lab Results for ATP\nBerger LabLab WebsitePrincipal Investigator:\nJames Berger, Ph.D.\nBiophysics and Biophysical Chemistry\nThe Berger Lab's research is focused on understanding how multi-subunit assemblies use ATP for ...overcoming topological challenges within the chromosome and controlling the flow of genetic information. A long-term goal is to develop mechanistic models that explain in atomic level detail how macromolecular machines transduce chemical energy into force and motion, and to determine how cells exploit and control these complexes and their activities for initiating DNA replication, shaping chromosome superstructure and executing myriad other essential nucleic-acid transactions.Research Areas: biochemistry, proteomics, ATP, DNA, genomics\nOur principal approaches include a blend of structural (X-ray crystallography, single-particle EM, SAXS) and solution biochemical methods to define the architecture, function, evolution and regulation of biological complexes. We also have extensive interests in mechanistic enzymology and the study of small-molecule inhibitors of therapeutic potential, the development of chemical approaches to trapping weak protein/protein and protein/nucleic acid interactions, and in using microfluidics and single-molecule approaches for biochemical investigations of protein dynamics. view more\nSteven Claypool LabLab WebsitePrincipal Investigator:\nSteven Claypool, Ph.D.\nResearch in the Claypool Lab is focused on defining how lipids and membrane proteins interact t...o establish and maintain normal mitochondrial function and how derangements in this complex relationship result in pathophysiology. We have demonstrated that yeast lacking tafazzin recapitulates all of the phospholipid abnormalities observed in human patients and many of the mitochondrial defects.Research Areas: biochemistry, proteomics, lipids, yeast, mitochondria, oxidative phosphorylation\nAnother major project in our lab focuses on the mitochondrial ADP/ATP carrier that is required for oxidative phosphorylation. Researchers are studying how these novel interactions help establish normal mitochondrial function, the biochemical details of these associations, and whether disturbances in these assemblies can contribute to mitochondrial dysfunction. view more", "domain": "chemistry", "round": 3} +{"url": "https://www.dentaldomain.ph/2015/ultraseal-a-seal-that-can-handle-moist/", "date": "2023-03-24T10:16:58Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-14/segments/1679296945279.63/warc/CC-MAIN-20230324082226-20230324112226-00642.warc.gz", "language_score": 0.9084685444831848, "token_count": 473, "dump": "CC-MAIN-2023-14", "global_id": "webtext-fineweb__CC-MAIN-2023-14__0__52998760", "lang": "en", "text": "Ultraseal – A Seal That Can Handle Moist\nA dental sealant is a tooth-colored plastic film that is professionally applied to the deep grooves or fissures on the back teeth or known as molars or posterior teeth where tooth decay most often starts. Because grooves in these teeth are so narrow that a toothbrush cannot fit into the spaces to remove plaque. So, dental sealants are basically intended to prevent dental decay in the grooves. Sealants can provide 100% protection from dental decay or “cavities” on the chewing surface. Research has shown that when placed over very minimal dental decay, the decay will no longer progress. However, unfortunately, the process of placing dentin sealant on the tooth can fail due to moisture as current sealants require a dry field so it can do what it has to do.\nThere’s now a sealant that can handle this moisture. Ultradent came up with the great solution by developing even better their award winning UltraSeal into Ultraseal XT Hydro. UltraSeal XT Hydro is the perfect solution for clinicians who are looking for a faster way to apply a pit and fissure sealant without compromising quality.\nUltraSeal XT Hydro is a light-cured, radiopaque, fluoride-releasing composite sealant. It is stronger and more wear resistant because it is a 53%-filled resin and has less polymerization shrinkage than competitive products. The spiral brush action of the Inspiral Brush tip causes shear thinning of the filled, thixotropic UltraSeal XT hydro, reducing its viscosity as it is placed. The resin firms when shear thinning ceases and placement is complete, preventing it from running before it can be light cured. The hydrophilic chemistry with its characteristic thixotropic nature chases moisture (that in hydrophobic sealants can cause sealant failure) deep into the pits and fissures on a microscopic level. Once there, the advanced adhesive technology securely bonds the sealant to the enamel, increasing marginal retention and reducing microleakage.\n- Hydrophilic chemistry\n- Advanced adhesive technology\n- Fluorescent properties\n- Highly filled resin\n- Two shades: Opaque White and Natural\n- Thixotropic/ideal viscosity", "domain": "chemistry", "round": 3} +{"url": "https://readtiger.com/wkp/en/TFM-4AS-1", "date": "2019-11-21T19:01:44Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-47/segments/1573496670948.64/warc/CC-MAIN-20191121180800-20191121204800-00456.warc.gz", "language_score": 0.8089778423309326, "token_count": 254, "dump": "CC-MAIN-2019-47", "global_id": "webtext-fineweb__CC-MAIN-2019-47__0__189287384", "lang": "en", "text": "|Chemical and physical data|\n|Molar mass||474.568 g·mol−1|\n|3D model (JSmol)|\nTFM-4AS-1 is a dual selective androgen receptor modulator (SARM) and 5α-reductase inhibitor. It is a potent and selective partial agonist (Emax = 55%) of the androgen receptor (IC50 = 30 nM) and inhibitor of 5α-reductase types I and II (IC50 = 2 and 3 nM, respectively). TFM-4AS-1 shows tissue-selective androgenic effects; it promotes the accumulation of bone and muscle mass and has reduced effects in reproductive tissues and sebaceous glands. In addition, it does not promote growth of the prostate gland and it antagonizes the actions of dihydrotestosterone (DHT) in the seminal vesicles. Structurally, TFM-4AS-1 is a 4-azasteroid.\n|This article about a steroid is a stub. You can help Wikipedia by expanding it.|\n|This drug article relating to the genito-urinary system is a stub. You can help Wikipedia by expanding it.|", "domain": "chemistry", "round": 3} +{"url": "https://paccon2016.com/regulated-shifts-in-reactive-oxygen-and-nitrogen-species-rons-activities-are/", "date": "2022-09-27T20:49:16Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-40/segments/1664030335058.80/warc/CC-MAIN-20220927194248-20220927224248-00368.warc.gz", "language_score": 0.9537177085876465, "token_count": 1101, "dump": "CC-MAIN-2022-40", "global_id": "webtext-fineweb__CC-MAIN-2022-40__0__71795768", "lang": "en", "text": "Regulated shifts in reactive oxygen and nitrogen species (RONS) activities are essential in maintaining the standard sequence and PTPRC development LY500307 of myogenesis. i.e. dihydroethidium (DHE) 4 7 diacetate (DAF-FM DA) and 5-(and-6)-chloromethyl-2′ 7 -dichlorodihydrofluorescein diacetate (CM-DCFH-DA). Data demonstrate that satellite television cell proliferation elevated when cells had been grown up in 6% O2 weighed against 20% O2. LY500307 Myoblasts harvested in 20% O2 demonstrated a rise in DCF fluorescence and DHE oxidation weighed against myoblasts harvested at 6% O2. Myotubes harvested in 20% O2 also demonstrated a rise in DCF and DAF-FM fluorescence and DHE oxidation weighed against myotubes harvested in 6% O2. The catalase and MnSOD items were also elevated in myoblasts and myotubes which were preserved in 20% O2 weighed against myoblasts and myotubes harvested in 6% O2. These data suggest that intracellular RONS actions in myoblasts and myotubes at rest are inspired by adjustments in environmental air concentration which the elevated ROS may impact myogenesis in a poor manner. involves very similar procedures to those taking place during myogenesis and will be examined in well-characterised cell lifestyle models. Environmentally friendly O2 concentration employed for satellite television cell cultivation is nearly generally 20% whereas regular adult skeletal muscle mass O2 amounts are considerably lower possibly between 1.8 and 10.5% . Environmental air concentration continues to be previously proven to adjust satellite television cell behavior LY500307 in an activity that is associated with reactive oxygen types (ROS) era . The systems where ROS mediate myogenesis are unclear but tend due to adjustments in gene appearance via redox-sensitive transcription aspect activation . Nevertheless the design of era of particular ROS in skeletal muscles cells through the LY500307 procedures of myogenesis under different air concentrations happens to be unknown. Desire to was as a result to examine the actions of RONS in cultured skeletal muscles cells under around physiological circumstances (6% air) weighed against 20% O2 and in addition determine the result of the various O2 concentrations on muscles myogenesis. Principal skeletal muscle civilizations were grown up in 20% or 6% air conditions and RONS had been evaluated at different levels LY500307 of myogenesis using RONS-sensitive fluorescent probes . Usage of these probes enables the evaluation of particular RONS in one cells instantly. The fluorescent probes dihydroethidium (DHE) 5 7 -dichlorodihydrofluorescein diacetate (CM-DCFH-DA) and 4-amino-5-methylamino-2′ 7 diacetate (DAF-FM DA) had been found in this research. DCFH reacts with hydrogen peroxide (H2O2) in the current presence of peroxidases and much less rapidly with various other ROS DAF-FM reacts without and peroxynitrite and DHE is normally mainly oxidised by superoxide. Adjustments in fluorescence in skeletal muscles myotubes and myoblasts were measured using fluorescence microscopy. Our hypothesis was that myoblasts and myotubes harvested in 20% O2 could have elevated superoxide content resulting in a rise in intracellular DCF and DHE oxidation but no influence on DAF-FM fluorescence weighed against cells harvested in 6% O2 and that would be connected with decreased myogenesis in the myoblasts harvested in 20% O2. 2 and strategies 2.1 Civilizations of skeletal muscle myoblasts and myotubes Myoblasts had been produced from adult (4-8 months previous) male wild-type (WT) mice. Principal mouse myoblasts were ready from hind quads as described previously. Briefly muscles had been digested in 0.1% pronase alternative. Cells had been cultured in 35?mm gelatin coated tissues culture plates in DMEM containing 20% (v/v) FCS. Cells had been incubated at 37?°C within a drinking water saturated atmosphere containing 5% (v/v) CO2 in either 20% or 6% air environments. To stimulate myotube development the moderate was changed with DMEM filled with 2% equine serum filled with 2% equine serum (HS) with 0.45% (test. Data were considered significant in is a lot decrease generally. In adult skeletal LY500307 muscles the physiological tissues O2 levels assessed by immediate microelectrode analysis differ between 1.8 and 10.5% based on electrode placement . These beliefs are well below the most common O2 culture circumstances. In today’s research we utilised fluorescence imaging microscopy to permit monitoring of real-time adjustments in RONS in principal cultures using satellite television cells isolated from WT mice that were preserved at 20% or 6% air conditions. We hypothesised that myoblasts and myotubes harvested in 20% O2 could have elevated.", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/fam91a1-antibody-ab81618.html", "date": "2020-09-19T08:58:31Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-40/segments/1600400191160.14/warc/CC-MAIN-20200919075646-20200919105646-00215.warc.gz", "language_score": 0.7588285803794861, "token_count": 515, "dump": "CC-MAIN-2020-40", "global_id": "webtext-fineweb__CC-MAIN-2020-40__0__271995259", "lang": "en", "text": "Key features and details\n- Rabbit polyclonal to FAM91A1\n- Suitable for: IP\n- Reacts with: Human\n- Isotype: IgG\nProduct nameAnti-FAM91A1 antibody\nDescriptionRabbit polyclonal to FAM91A1\nTested applicationsSuitable for: IPmore details\nUnsuitable for: WB\nSpecies reactivityReacts with: Human\nPredicted to work with: Mouse, Rat, Rabbit, Horse, Chicken, Guinea pig, Dog, Turkey, Pig, Chimpanzee, Rhesus monkey, Gorilla, Orangutan, Xenopus tropicalis, Platypus\nSynthetic peptide corresponding to a region between residue 300 and 350 of human FAM91A1 (NP_659400.2)\n- Whole cell lysate from HeLa cells.\nStorage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.\nStorage bufferPreservative: 0.09% Sodium azide\nConstituents: 1.815% Tris, 1.764% Sodium citrate, 0.021% PBS\nConcentration information loading...\nPurityImmunogen affinity purified\nPurification notesab81618 was affinity purified using an epitope specific to FAM91A1 immobilized on solid support.\nOur Abpromise guarantee covers the use of ab81618 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\nIs unsuitable for WB.\nNot yet tested in other applications.\nOptimal dilutions/concentrations should be determined by the end user.\nRelevanceFAM91A1 (family with sequence similarity 91, member A1) is a 94 kDa hypothetical phospho protein that is not yet characterized.\n- DKFZp666B104 antibody\n- FAM91A1 antibody\n- Family with sequence similarity 91 member A1 antibody\nTo our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.\nab81618 has been referenced in 1 publication.\n- Navarro Negredo P et al. The WDR11 complex facilitates the tethering of AP-1-derived vesicles. Nat Commun 9:596 (2018). PubMed: 29426865", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/nsfl1c-antibody-ab234785.html", "date": "2020-10-20T21:13:59Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-45/segments/1603107874135.2/warc/CC-MAIN-20201020192039-20201020222039-00505.warc.gz", "language_score": 0.7612463235855103, "token_count": 584, "dump": "CC-MAIN-2020-45", "global_id": "webtext-fineweb__CC-MAIN-2020-45__0__187913463", "lang": "en", "text": "Key features and details\n- Rabbit polyclonal to NSFL1C\n- Suitable for: IHC-P\n- Reacts with: Human\n- Isotype: IgG\nProduct nameAnti-NSFL1C antibody\nSee all NSFL1C primary antibodies\nDescriptionRabbit polyclonal to NSFL1C\nTested applicationsSuitable for: IHC-Pmore details\nSpecies reactivityReacts with: Human\nRecombinant fragment corresponding to Human NSFL1C aa 1-185.\nDatabase link: Q9UNZ2\n- IHC-P: Human testis and lung cancer tissues.\nStorage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.\nStorage bufferpH: 7.30\nPreservative: 0.02% Sodium azide\nConstituents: PBS, 50% Glycerol\nConcentration information loading...\nPurityImmunogen affinity purified\nOur Abpromise guarantee covers the use of ab234785 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\n|IHC-P||1/20 - 1/200.|\nFunctionReduces the ATPase activity of VCP. Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER) (By similarity). Inhibits the activity of CTSL (in vitro).\nSequence similaritiesBelongs to the NSFL1C family.\nContains 1 SEP domain.\nContains 1 UBX domain.\nmodificationsPhosphorylated during mitosis. Phosphorylation inhibits interaction with Golgi membranes and is required for the fragmentation of the Golgi stacks during mitosis.\nCellular localizationNucleus. Golgi apparatus > Golgi stack. Chromosome. Predominantly nuclear in interphase cells. Bound to the axial elements of sex chromosomes in pachytene spermatocytes. A small proportion of the protein is cytoplasmic, associated with Golgi stacks.\n- Information by UniProt\n- DJ776F14.1 antibody\n- MGC3347 antibody\n- NSF1C_HUMAN antibody\nTo our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.\nab234785 has not yet been referenced specifically in any publications.", "domain": "chemistry", "round": 3} +{"url": "http://expert.knowledgetransferireland.com/experts/1088237", "date": "2021-09-21T03:34:04Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-39/segments/1631780057131.88/warc/CC-MAIN-20210921011047-20210921041047-00326.warc.gz", "language_score": 0.7802428603172302, "token_count": 499, "dump": "CC-MAIN-2021-39", "global_id": "webtext-fineweb__CC-MAIN-2021-39__0__81325607", "lang": "en", "text": "Trinity College Dublin\n|As first author||42|\n|As last author||103|\nJonathan A. Kitchen(22)\nD Clive Williams(19)\nSusan J. Quinn(19)\nJohn Moffat Kelly(16)\nPaul E Kruger(14)\nRobert D Peacock(13)\nRobert B.P. Elmes(13)\nFergus E Poynton(11)\nJohn E O'Brien(10)\nSandra A Bright(10)\nChris S Hawes(10)\nEmma B Veale(9)\nJoseph P. Byrne(8)\n... and 44 others\nThese arethe8 unique sources for Thorfinnur Gunnlaugsson's 168 publications. A single publication may appear in multiple sources. Click on a name or publication count to see the publications for a particular source.\n|Ireland -> Dublin City University||1|\n|Ireland -> Dublin City University -> PubMed||1|\n|Ireland -> Maynooth University||10|\n|Ireland -> Maynooth University -> PubMed||1|\n|Ireland -> Trinity College Dublin||156|\n|Ireland -> Trinity College Dublin -> PubMed||103|\n|Ireland -> University College Dublin||12|\n|Ireland -> University College Dublin -> PubMed||3|\nA sensor element suitable for colorimetric detection of anions in a sample, the sensor element comprising a water insoluble polymeric hydrogel having a polymer network defining a water permeable microvoid network, and an anion recognition dye (receptor) incorporated into the polymeric hydrogel. The anion recognition dye has a general formula (I), Wherein R1, R2, R3 and R4 are each, independently, selected from H or an optionally substituted group consisting of lower alkyl, allyl, aryl, thioureas, urea, amide, ether, and X is S or O. An anion detection probe comprising a support that incorporates the sensor element and provided in the form of a dip-stick is also disclosed.\nClicking through these tabs will give you a wealth of further insights into this expert through their commonly used topics, the evolution of their expertise, their collaborators and their publications.\nHere is a quick breakdown of this expert's publication history\nIf this is the expert you have been looking for, simply click here to make contact.", "domain": "chemistry", "round": 3} +{"url": "http://grantome.com/grant/NIH/R13-AI114065-01", "date": "2020-01-22T20:56:06Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-05/segments/1579250607407.48/warc/CC-MAIN-20200122191620-20200122220620-00381.warc.gz", "language_score": 0.9446933269500732, "token_count": 467, "dump": "CC-MAIN-2020-05", "global_id": "webtext-fineweb__CC-MAIN-2020-05__0__105233583", "lang": "en", "text": "With this proposal we seek partial support for the 2014 and 2015 \"\"\"\"\"\"\"\"Enzymes, Coenzymes, and Metabolic Pathways\"\"\"\"\"\"\"\" Gordon Research Conference. These conferences will occur from July 13 - 18, 2014 and in July 2015 at the Waterville Valley Resort, in Waterville Valley, NH. The 'Enzymes'GRC is the pivotal conference for researchers focused on investigating the molecular mechanisms of biochemical reactions, and provides a central meeting place for the exchange of ideas. The long-term goals of this conference are to foster interactions and communication within the research community focused on studying the roles of enzymes in the biological processes that are fundamental for life. To achieve these goals, we will assemble a program of ~36 speakers that comprise 28 invited talks and 8 chosen from poster abstracts. These talks will describe current advances in enzyme mechanisms, chemical biology, cancer biology and antibiotic resistance, as well as how these areas link to both normal and pathological life processes. During the afternoon, poster sessions will be held where all attendees can present their work to the broader community of scientists. These poster sessions provide a unique opportunity for junior scientists and senior investigators to interact. This proposal is highly significant because the Enzymes, Co-Enzymes and Metabolic Pathways GRC is the pivotal conference for researchers focused on investigating the molecular mechanisms of biochemical reactions, and provides a central meeting place for the exchange of ideas. Furthermore, this meeting continues to showcase the very best in enzyme and metabolic studies as well as their relevance to human diseases. From a medical perspective, this proposal is highly significant due to the focus areas of cancer and anti-bacterials. A key outcome of this proposal will be to further advance our understanding of how enzymes, co-enzymes and metabolic pathways contribute to the onset and progression of cancer, to the development of antibiotic resistance, and how these can be targeted by the development of novel therapeutics.\nBoth healthy and pathophysiology is driven by an interconnected set of chemical reactions catalyzed by enzymes and co-enzymes. Understanding these catalysts and the metabolic pathways they comprise is critical for the development of new drugs. This meeting allows presentation and discussion of cutting-edge research on how these processes occur, how they are regulated and how we can manipulate them to improve human health.", "domain": "chemistry", "round": 3} +{"url": "http://www.int-res.com/abstracts/meps/v257/p69-76/", "date": "2017-04-30T16:50:01Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-17/segments/1492917125719.13/warc/CC-MAIN-20170423031205-00541-ip-10-145-167-34.ec2.internal.warc.gz", "language_score": 0.9101520776748657, "token_count": 350, "dump": "CC-MAIN-2017-17", "global_id": "webtext-fineweb__CC-MAIN-2017-17__0__103939059", "lang": "en", "text": "MEPS 257:69-76 (2003) - doi:10.3354/meps257069\nEffect of salinity on growth, pigmentation, N2 fixation and alkaline phosphatase activity of cultured Trichodesmium sp.\nFei-Xue Fu*, P. R. F. Bell\nABSTRACT: Trichodesmium sp. isolated from the Great Barrier Reef lagoon was cultured in artificial seawater media containing a range of salinities. Trichodesmium sp. actively grew over a wide range of salinities (22 to 43 psu) and hence can be classed as euryhaline. Maximum growth occurred with salinities in the range 33 to 37 psu. Chl a content and alkaline phosphatase activity were found to increase with salinity over the range 22 to 43 psu, but the N2 fixation rate was reduced at salinities below and above the range for maximum growth. Growth in media exhibiting maximum growth was characterised by well-dispersed cultures of filaments, while significant aggregations of filaments formed in other media. It is proposed that the tendency for Trichodesmium filaments to aggregate in media with salinities outside the range for maximum growth is an opportunistic response to a deficiency of cellular nitrogen, which results from the reduced N2 fixation rates, and the aggregation occurs in order to enhance the uptake of combined N released within the aggregates and/or the N2 fixation within the aggregates.\nKEY WORDS: Trichodesmium sp. · Salinity · N2 fixation · Alkaline phosphatase activity\n|Full text in pdf format|", "domain": "chemistry", "round": 3} +{"url": "https://www.scientific.net/AMR.26-28.1341", "date": "2018-12-15T16:22:35Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-51/segments/1544376826892.78/warc/CC-MAIN-20181215152912-20181215174912-00054.warc.gz", "language_score": 0.8772023916244507, "token_count": 287, "dump": "CC-MAIN-2018-51", "global_id": "webtext-fineweb__CC-MAIN-2018-51__0__248340091", "lang": "en", "text": "First Principles Study on the Adsorption of Alkali Metal on C(100)( 2×1)\nFirst-principles calculations based on density functional theory, using PW91 functional have been performed to study the adsorption of Alkali metal (AM) on C(100)(2×1) surface. The stable geometries, adsorption energies for all adsorption configurations have been calculated on half a monolayer and one monolayer. The preferred binding sites have been determined to be valley-bridge sites at the coverage of 0.5ML. At higher coverage of 1ML, two AM adsorbates were found to reside in pedestal site and valley-bridge site, respectively. Work function analysis showed that when AMs are adsorbed on C(100)(2×1) surface, the work function decreases linearly with increasing coverage and reaches a minimum at Θ=0.5ML. At higher coverage, the work function is increased again, which may be caused by depolarization effect of the adsorbate.\nYoung Won Chang, Nack J. Kim and Chong Soo Lee\nJ.L. Nie et al., \"First Principles Study on the Adsorption of Alkali Metal on C(100)( 2×1)\", Advanced Materials Research, Vols. 26-28, pp. 1341-1344, 2007", "domain": "chemistry", "round": 3} +{"url": "http://nybro.info/hustler/can-carbon-hookup-be-used-on-fossils.php", "date": "2018-12-10T23:58:56Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-51/segments/1544376823516.50/warc/CC-MAIN-20181210233803-20181211015303-00527.warc.gz", "language_score": 0.9073505997657776, "token_count": 426, "dump": "CC-MAIN-2018-51", "global_id": "webtext-fineweb__CC-MAIN-2018-51__0__22127652", "lang": "en", "text": "Dating Methods | Answers in Genesis\n10 Jul Geologists do not use carbon-based radiometric dating to determine the age of rocks. Carbon dating only works for objects that are younger than abo. Fossil dating definition, definition of radiocarbon dating in science, short definition of carbon dating, definition of indirect dating, dating definition webster dictionary Hook up definition dating Back in the most widely used forms of your penis size of your penis can vitamins cause impotence erectile dysfunction or charge. 16 Nov Absolute dating is used to determine a precise age of a fossil by using radiometric dating to measure the decay of isotopes, either within the fossil or more often the rocks So, often layers of volcanic rocks above and below the layers containing fossils can be dated to provide a date range for the fossil.\n- While people are most familiar with carbon dating, carbon dating is rarely applicable to fossils. Carbon, the radioactive isotope of carbon used in carbon dating has a half-life of years, so it decays too fast. It can only be used to date fossils younger than about 75, years. Potassium on the other hand has a half.\n- In that instance you can select the amount you inclination to victory about reckoning the trifle away sector on the dial and reducing the carry off the palm sector.\n- Geologists have established a set of principles that can be applied to sedimentary and volcanic rocks that are exposed at the Earth's surface to determine the . Geologists commonly use radiometric dating methods, based on the natural radioactive decay of certain elements such as potassium and carbon, as reliable clocks.\nLooks like you are using an obsolete version of Net Explorer - See fit update your browser. If you already have an lowdown, Sign in.\nGreater scientists and myriad Christians believe that the radiometric dating methods prove that the earth is 4. Recent check out shows otherwise.\n- Middle eastern part soooo true\n- You know you are dating a hungarian woman when.\nThe textbooks talk to of the radiometric dating techniques, and the dates themselves, as factual dope.", "domain": "chemistry", "round": 3} +{"url": "https://chemical-biomolecular.engr.uconn.edu/category/conferences/", "date": "2023-11-29T12:42:59Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100081.47/warc/CC-MAIN-20231129105306-20231129135306-00156.warc.gz", "language_score": 0.9375337362289429, "token_count": 499, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__126591636", "lang": "en", "text": "Students of the CBE department excelled at AIChE’s Undergraduate Poster Competition this November. Despite fierce competition among more than 300 student presenters, six UConn Chemical Engineers took home prizes.\nThe 2014 AIChE (American Institute of Chemical Engineers) Annual Meeting was held in Atlanta, Georgia this year. It is the premier forum for chemical engineers, and academic and industry experts presented developments on a wide range of topics relevant to cutting-edge research, new technologies, and emerging growth areas in chemical engineering.\nOver the years, the Undergraduate Poster Session has become one of the highlights of the conference. Competing students each prepared a poster detailing progress and contributions on their independent research projects. During the conference, the students presented their work to individual judges. Over 80 judges were in attendance, all of which were senior AIChE members from academia or industry.\nThe research categories included: Catalysis and Reaction Engineering; Sustainability; Food, Pharmaceutical and Biotechnology; Separations; Environmental; Education; Fuels, Petrochemicals and Energy; Computing and Process Control; and Materials Engineering and Sciences. Awards were presented to the top posters in each division.\nWe’re pleased to announce that the following UConn CBE undergraduates won in their divisions:\n- Gabriella Frey – 1st Place in Separations\n“Formulating Draw Solution Mixtures for Forward Osmosis”\n- Gianna Credaroli – 2nd Place in Separations\n“A New Thin Film Composite Membrane”\n- Oscar Nordness – 2nd place in energy fuels and petrochemicals\n“Incorporation of High Pressure CLC into IGCC systems”\n- Abbey Wangstrom – 2nd place in Reaction and Catalysis Engineering\n“High Activity, High Stability Pt/ITO Fuel Cell Catalysts”\n- Clarke Palmer – 3rd Place in Fuels, Petrochemicals, and Energy\n“Reactor Design and Analysis of a Simulated moving Bed Reactor for Chemical-Looping Combustion”\n- Ari Fischer – 3rd Place in Catalysis and Reaction Engineering\n“Thermochemical CO2 and H2O Splitting Via Chemical-Looping with Cerium and Cobalt Mixed Oxides for Oxygen Generation”\nAfter their hard work, the CBE faculty treated our undergraduates to a night on the town.", "domain": "chemistry", "round": 3} +{"url": "https://jhu.pure.elsevier.com/en/publications/current-orthopaedic-surgeon-use-of-bioresorbable-beads-for-antibi", "date": "2022-05-19T23:12:07Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-21/segments/1652662530066.45/warc/CC-MAIN-20220519204127-20220519234127-00692.warc.gz", "language_score": 0.9381580948829651, "token_count": 351, "dump": "CC-MAIN-2022-21", "global_id": "webtext-fineweb__CC-MAIN-2022-21__0__223436997", "lang": "en", "text": "Current orthopedic foot and ankle surgery involves frequent patient issues of soft-tissue infection and osteomyelitis, the treatment of which often involves both systemic and local antibiotics. Treatment options have advanced over the past 25 years from antibiotics in polymethylmethacrylate beads to antibiotics in resorbable carriers such as calcium sulfate and calcium phosphate. Current preference is the use of vancomycin and gentamycin mixed in with a calcium sulfate powder that crystalizes in a standard fashion to beads. The newer generation of antibiotic beads offers reliable elution of antibiotics and slow resorption of carriers. Prior beads, mixed with a different calcium sulfate, produced beads that delivered antibiotics but with significant drainage for weeks after implantation. While some of the information about these bead formulations is public, standards for bead composition, crystalline structure, elution, and resorption have yet to be developed. The various antibiotics may have profound effects on the beads as well. Current use of antibiotic calcium sulfate beads includes intraoperative implantation into bone or soft-tissue voids, or both. The time frame for observation and repeat implantation remains a clinical decision. The beads have also enjoyed use in our offices for placement in postoperative wound infections or minor wound dehiscence. This “off-label” use of antibiotic beads has significantly reduced the need for reoperation and has treated many minor infections in a major orthopedic foot and ankle training program. Such treatments are difficult subjects for academic papers given the various clinical presentations, but certainly a better understanding of the physical properties of the antibiotic beads would be helpful in guiding clinical practice. In addition, as other companies produce new formulations, physicians need a method of comparison.", "domain": "chemistry", "round": 3} +{"url": "http://www.hydro.uni-bayreuth.de/hydro/?lang=en", "date": "2018-02-19T04:02:34Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-09/segments/1518891812327.1/warc/CC-MAIN-20180219032249-20180219052249-00375.warc.gz", "language_score": 0.8272290229797363, "token_count": 463, "dump": "CC-MAIN-2018-09", "global_id": "webtext-fineweb__CC-MAIN-2018-09__0__88542933", "lang": "en", "text": "Welcome to Hydrology!\nThe main focus of research at the Department of Hydrology is the investigation of processes at the interface of groundwater and surface water. This interface is of fundamental importance for numerous processes affecting the quality of surface waters (streams, lakes) as well as groundwater as the two aquatic systems possess different chemical and physical properties. This interface offers ideal conditions for an efficient biological degradation of nutrients and contaminants, meaning that processes at the interface between surface and groundwater contribute considerably to nutrient cycling and buffer capacity in aquatic ecosystems.\nThe department conducts field, lab and modeling investigations that focus on gaining a quantitative process understanding of aquatic systems and address questions of performance and efficiency of matter processing but also vulnerability of aquatic systems, resulting from climate change or anthropogenic influences in general. The overarching goal is to obtain a better understanding of the coupling of physical and biogeochemical processes that control the cycling of matter and energy at the interface of surface waters and groundwater.\nWe have four closely linked research priorities:\nGilfedder, B; Peiffer, S; Pöschke, F; Spirkaneder, A: Grundwasserzufluss zum Steißlinger See und Folgen für die Wasserchemie, , Grundwasser (2018), doi:https://doi.org/10.1007/s00767-017-0386-8 [Link]\nWan, M; Schröder, C; Peiffer, S: Fe(III):S(-II) Concentration Ratio Controls the Pathway and the Kinetics of Pyrite Formation during Sulfidation of Ferric Hydroxides, Geochim. Cosmochim. Acta, 2017, 334-348 (2017), doi:https://doi.org/10.1016/j.gca.2017.08.036 [Link]\nKlug, M; Janneck, E; Reichel, Susan; Peiffer, S: Treatment of chromate(VI) and vandate(V) polluted wastewaters using schwertmannite adsorbents, , Proceedings IMWA 2016 / Mining Meets Water - Conflicts and Solutions, 1012-1014 (2016), online: 2016-08-11", "domain": "chemistry", "round": 3} +{"url": "https://www.asiaipex.com/IP/Details_SC/420935", "date": "2023-11-30T17:20:34Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100229.44/warc/CC-MAIN-20231130161920-20231130191920-00708.warc.gz", "language_score": 0.7180389761924744, "token_count": 376, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__237104859", "lang": "en", "text": "15-mer Histidin (Yeda)\n- 236-237 - Diastereomer Lytic Peptides for Treatment of Solid Tumors and Metastasis\nDescription: 15-mer (Leu-Lys-Dleu- Leu-Lys-Dlys-Leu-Dleu-Dlys-Lys-Leu-Leu-Dlys-Leu-Leu) and 15-mer Histidin (H-Leu-Lys-D-Leu- Leu-His-D-Lys-Leu-D-Leu-D-Lys-His-Leu-Leu-D-Lys-Leu-Leu-NH2) are membrane-active peptides composed of both D- and L amino acids (diastereomers). These peptides have demonstrated potent anti-cancer and anti metastatic activities in several animal models including models for prostate and lung cancer. They were shown to successfully inhibit tumor growth when injected intratumorally or intraveneously. The 15-mer Histidine form shows reduced systemic toxicity.\nReferences: Papo N, Braunstein A, Eshhar Z, Shai Y. 2004. Suppression of human prostate tumor growth in mice by a cytolytic D-, L-amino Acid Peptide: membrane lysis, increased necrosis, and inhibition of prostate-specific antigen secretion. Cancer Res. 64(16):5779-86.\nMakovitzki A1, Fink A, Shai Y. 2009. Suppression of human solid tumor growth in mice by intratumor and systemic inoculation of histidine-rich and pH-dependent host defense-like lytic peptides. Cancer Res. 69(8):3458-63.", "domain": "chemistry", "round": 3} +{"url": "http://www.genetex.com/PCCA-antibody-GTX114618.html", "date": "2017-04-24T20:49:41Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-17/segments/1492917119838.12/warc/CC-MAIN-20170423031159-00041-ip-10-145-167-34.ec2.internal.warc.gz", "language_score": 0.740009069442749, "token_count": 399, "dump": "CC-MAIN-2017-17", "global_id": "webtext-fineweb__CC-MAIN-2017-17__0__231514809", "lang": "en", "text": "|Full Name||propionyl CoA carboxylase, alpha polypeptide|\n|Product Description||Rabbit Polyclonal antibody to PCCA (propionyl CoA carboxylase, alpha polypeptide)|\n|Background||The protein encoded by this gene is the alpha subunit of the heterodimeric mitochondrial enzyme Propionyl-CoA carboxylase. PCCA encodes the biotin-binding region of this enzyme. Mutations in either PCCA or PCCB (encoding the beta subunit) lead to an enzyme deficiency resulting in propionic acidemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]|\n|Synonyms||PCCA antibody, propanoyl-CoA:carbon dioxide ligase alpha subunit antibody, \"propionyl Coenzyme A carboxylase, alpha polypeptide antibody\", \"propionyl-CoA carboxylase alpha chain, mitochondrial antibody\", PCCase alpha subunit antibody, pccA complementation group antibody, \"propionyl CoA carboxylase, alpha polypeptide antibody\"|\n|Cellular Localization||Mitochondrion matrix|\n|Immunogen||Recombinant protein encompassing a sequence within the C-terminus region of human PCCA. The exact sequence is proprietary.|\n|Predicted Cross Reactivity species Predicted cross-reactivity:|\nPredicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.\nPlease note that we are only able to guarantee products to work in applications and species in which they have been tested.\n|Mouse, Rat, Bovine|\n|Predict Reactivity Note||Mouse (86%), Rat (86%), Bovine (84%)|", "domain": "chemistry", "round": 3} +{"url": "https://czo-archive.criticalzone.org/luquillo/publications/pub/stone-plante-2013-changes-in-phosphatase-kinetics-with-soil-depth-across-a-/", "date": "2021-02-28T15:23:21Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-10/segments/1614178361510.12/warc/CC-MAIN-20210228145113-20210228175113-00599.warc.gz", "language_score": 0.9228447675704956, "token_count": 551, "dump": "CC-MAIN-2021-10", "global_id": "webtext-fineweb__CC-MAIN-2021-10__0__163473798", "lang": "en", "text": "Phosphatase enzymes play a key role cycling phosphorus from organic to plant-available pools, particularly in tropical soils where inorganic phosphorus is often limited. However, most studies of phosphatase activity have focused only on surface soils, despite the large quantities of carbon and nutrients stored in tropical subsoils. The goal of this study was to determine how acid phosphatase kinetic parameters change with depth across two parent materials (represented by Oxisols and an Inceptisols) and two distinct forests (lower and upper montane) at the Luquillo Critical Zone Observatory in northeast Puerto Rico. We collected samples from five soil pits at each of four soil forest types, and measured apparent phosphatase kinetic parameters (AppVmax and AppKm) and soil nutrients at 0, 20, 50, 80, 110 and 140 cm depths. Across all sites, AppVmax declined 97% and AppKm declined 85% from the surface to 140 cm depth. The ratio of AppVmax to AppKm (i.e., Ka) did not change through the first meter of soil profiles but was significantly reduced by 50% 140 cm. Total carbon, nitrogen and extractable phosphorus all declined exponentially with depth. Carbon concentrations and AppVmax were both significantly greater in Oxisols compared with Inceptisols, and in the higher elevation montane forest compared to the lower elevation forest. The scaling relationship we observe between AppVmax and AppKm is common for environmental systems, although the degree of correlation in our study (R2 = 0.48) is unusually high, suggesting these parameters are both driven by changes in energy and nutrient availability along depth profiles. However, the consistency of Ka with depth indicates that overall catalytic capacity of phosphatase is maintained across a range of substrate concentrations. The larger variability in AppVmax compared with AppKm suggests microorganisms exert more control over phosphatase production than substrate availability. Our findings indicate that subsoil microbial communities are not metabolically dormant, but rather contribute to P-cycling at rates comparable to their surface counterparts. Further research on ecology of microorganisms in resource-limited tropical subsoils is warranted to better understand microbial contributions to biogeochemical cycles throughout tropical soil profiles.\nKeywords: acid phosphatase, phosphorus, enzyme kinetics, tropical subsoil, Luquillo\nStone, M.M., Plante, A.F. (2014): Changes in phosphatase kinetics with soil depth across a variable tropical landscape. Soil Biology & Biochemistry. DOI: 10.1016/j.soilbio.2014.01.006\nThis Paper/Book acknowledges NSF CZO grant support.", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/tet1-antibody-ab220867.html", "date": "2020-10-22T21:03:07Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-45/segments/1603107880038.27/warc/CC-MAIN-20201022195658-20201022225658-00272.warc.gz", "language_score": 0.7720874547958374, "token_count": 587, "dump": "CC-MAIN-2020-45", "global_id": "webtext-fineweb__CC-MAIN-2020-45__0__111542758", "lang": "en", "text": "Key features and details\n- Rabbit polyclonal to TET1\n- Suitable for: ICC/IF\n- Reacts with: Human\n- Isotype: IgG\nStorage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.\nStorage bufferpH: 7.20\nPreservative: 0.02% Sodium azide\nConstituents: 40% Glycerol (glycerin, glycerine), 59% PBS\nConcentration information loading...\nPurityImmunogen affinity purified\nOur Abpromise guarantee covers the use of ab220867 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\n|ICC/IF||Use a concentration of 0.25 - 2 µg/ml.\nFixation/Permeabilization: PFA/Triton X-100.\nFunctionDioxygenase that catalyzes the conversion of methylcytosine (5mC) to 5-hydroxymethylcytosine (hmC). Plays a role in embryonic stem (ES) cell maintenance and inner cell mass (ICM) cell specification, possibly by participating in DNA demethylation. Specifically binds 5mC, a minor base in mammalian DNA found in repetitive DNA elements that is crucial for retrotransposon silencing and mammalian development. 5mC is present in ES cells and is enriched in the brain, especially in Purkinje neurons. The clear function of hmC is still unclear but it could constitute an intermediate component in cytosine demethylation. A role of hmC in DNA demethylation is supported by TET1 function in ES cell maintenance, which is required to prevent NANOG hypermethylation and maintain NANOG expression in ES cells.\nTissue specificityExpressed in fetal heart, lung and brain, and in adult skeletal muscle, thymus and ovary. Not detected in adult heart, lung or brain.\nInvolvement in diseaseNote=A chromosomal aberration involving TET1 may be a cause of acute leukemias. Translocation t(10;11)(q22;q23) with MLL. This is a rare chromosomal translocation 5' MLL-TET1 3'.\nSequence similaritiesBelongs to the TET family.\nContains 1 CXXC-type zinc finger.\n- Information by UniProt\n- bA119F7.1 antibody\n- CXXC 6 antibody\n- CXXC finger 6 antibody\nab220867 has not yet been referenced specifically in any publications.", "domain": "chemistry", "round": 3} +{"url": "https://rsglobal.pl/index.php/ws/article/view/106", "date": "2022-11-30T16:12:01Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-49/segments/1669446710765.76/warc/CC-MAIN-20221130160457-20221130190457-00461.warc.gz", "language_score": 0.7170100808143616, "token_count": 3978, "dump": "CC-MAIN-2022-49", "global_id": "webtext-fineweb__CC-MAIN-2022-49__0__149541577", "lang": "en", "text": "CEMENT SELECTION IN DENTAL PRACTICE\nThe cementation procedure is considered to be the most important stage of fixed prosthodontics, while the correct selection of cement is the guarantee of successful restoration which is conditioned by the its durability. Over the recent years, numerous cementing substances have been introduced to the dental practice that differ greatly from conventional cements with their properties and application methods and that is why even experienced dentists often have certain difficulties in the variety of cements to choose the one that is right for each clinical case. The selection of cement depends on a number of factors, such as the type of resorption substance, the shape of prepared tooth, the possibility to isolate the area, subject to cementation in the oral cavity as well as the patient’s aesthetic requirements. Thus, the objective of the article is to analyze currently used dental cements in order to help the dentists make the right selection of cement for different clinical cases.\nHill EE, Lott J. A clinically focused discussion of luting materials. Australian Dental Journal. 2011; 56 (Suppl 1): 67-76.\nImazato S, Ma S, Chen J, Xu H. Therapeutic polymers for dental adhesives: loading resins with bio-active components. Dent Mater. 2014;30(1):97-104\nSonarkars S, Purba R. Bioactive materials in conservative dentistry. International Journal of Contemporary Dental and Medical Reviews. 2015. Article ID 340115. doi: 10.15713/ins.ijcdmr.47\nAsthana G, Bhargava S. Bioactive materials: A comprehensive review. Scholars Journal of Applied Medical Sciences. 2014;2(6E):3231-3237.\nNiu L, Zhang W, Pashley D, et al. Biomimetic remineralization of dentin. Dent Mater. 2014;30(1):77-96\nEngstrand J, Unosson E, Engqvist H. Hydroxyapatite formation on a novel dental cement in human saliva. ISRN Dentistry. (2012): Article ID 624056.\nPameijer CH, Jefferies S, Lööf J, Hermansson L. Microleakage evaluation of XeraCemTM in cemented crowns. J Dent Res. 2008;87(B):3098.\nUnosson E, Cai Y, Jiang X. Antibacterial properties of dental luting agents: Potential to hinder the development of secondary caries. International Journal of Dentistry. (2012): Article ID 529495.\nPameijer CH, Jefferies SR, Lööf J, Hermansson L. A comparative crown retention test using XeraCemTM. J Dent Res. 2008;87(B):3099.\nAttar N, Tam LE, McComb D. Mechanical and physical properties of contemporary dental luting agents. Journal of Prosthetic Dentistry. 2003; 89: 127-134.\nde la Macorra JC, Pradies G. Conventional and adhesive luting cements. Clinical Oral Investigations. 2002; 6: 198-204.\nPegoraro TA, da Silva NR, Carvalho RM. Cements for use in esthetic dentistry. Dental Clinics of North America. 2007; 51: 453-471.\nErkut S, Kucukesmen HC, Eminkahyagil N, Imirzalioglu P, Karabulut E. Influence of previous provisional cementation on the bond strength between two definitive resin-based luting and dentin bonding agents and human dentin. Operative Dentistry. 2007; 32: 84-93.\nRibeiro JC, Coelho PG, Janal MN, Silva NR, Monteiro AJ, et al. The influence of temporary cements on dental adhesive systems for luting cementation. Journal of Dentistry. 2011; 39: 255-262.\nSilva JP, Queiroz DM, Azevedo LH, Leal LC, Rodrigues JL, et al. Effect of eugenol exposure time and post-removal delay on the bond strength of a self-etching adhesive to dentin. Operative Dentistry. 2011; 36: 66-71.\nAltintas SH, Tak O, Secilmis A, Usumez A. Effect of provisional cements on shear bond strength of porcelain laminate veneers. European Journal of Dentistry. 2011; 5: 373-379.\nGalazi DR, Brianezze LF, de Goes AR, et al. Influence of temporary cement in the tensile strength of full crowns cement with a resin cement. Brazilian Dental Science. 2015;18(3):52-58.\nPameijer CH. A review of luting agents. International Journal of Dentistry. 2012: 752861.\nSailer I, Oendra AE, Stawarczyk B, Hammerle CH. The effects of desensitizing resin, resin sealing, and provisional cement on the bond strength of dentin luted with self-adhesive and conventional resincements. Journal of Prosthetic Dentistry. 2012; 107: 252-260.\nBagis B, Bagis YH, Hasanreisoglu U. Bonding effectiveness of a self-adhesive resin-based luting cement to dentin after provisional cement contamination. Journal of Adhesive Dentistry. 2011; 13: 543-550.\nRosenstiel SF, Land MF, Crispin BJ. Dental luting agents: A review of the current literature. Journal of Prosthetic Dentistry. 1998; 80: 280-301.\nLad PP, Kamath M, Tarale K, Kusugal PB. Practical clinical considerations of luting cements: A review. J Int Oral Health. 2014;6(1):116-120\nCraig RG, Powers JM. Restorative Dental Materials. (13th edn). St Louis: Mosby; 2012.\nCharlton DG, Moore BK, Swartz ML (1991) Direct surface pH determinations of setting cements. Operative Dentistry. 1991; 16: 231-238.\nHabib B, von Fraunhofer JA, Driscoll CF. Comparison of two luting agents used for the retention of cast dowel and cores. Journal of Prosthodontics. 2005; 14: 164-169.\nRosenstiel SF, Rashid RG. Postcementation hypersensitivity: scientific data versus dentists' perceptions. Journal of Prosthodontics. 2003; 12: 73-81.\nMojon P, Kaltio R, Feduik D, Hawbolt EB, MacEntee MI. Short-term contamination of luting cements by water and saliva. Dental Materials. 1996; 12: 83-87.\nJohnson GH, Hazelton LR, Bales DJ, Lepe X. The effect of a resin-based sealer on crown retention for three types of cement. Journal of Prosthetic Dentistry. 2004; 91: 428-435.\nPameijer CH. A review of luting agents. Int J Dent. 2012;2012:752861. doi: 10.1155/2012/752861\nYu H, Zheng M, Chen R, Cheng H. Proper selection of contemporary dental cements. Oral Health Dent Manag. 2014;13(1):54-59.\nXu X, Burgess JO. Compressive strength, fluoride release and recharge of fluoride-releasing materials. Biomaterials. 2003; 24: 2451-2461.\nMcCabe JF, Walls AWG. Applied Dental Materials. (8th edn). Oxford: Blackwell Publishing Company; 2005.\nSita Ramaraju DV, Rama Krishna A, Venkata Ramaraju A, Raju MAKV. A review of conventional and contemporary luting agents used in dentistry. American Journal of Materials Science and Engineering. 2014;2(3):28-35.\nO'Brien W. Dental Materials and their selection. (3rd edn.). Chicago: Quintessence International; 2002\nSimon JF, Darnell LA. Considerations for proper selection of dental cements. Compend Contin Educ Dent. 2012;33(1):28-36.\nZidan O, Ferguson GC. The retention of complete crowns prepared with three different tapers and luted with four different cements. J Prosthet Dent. 2003;89(6):565-571.\nPreis V, Behr M, Hahnel S, Rosentritt M. Influence of cementation on in vitro performance, marginal adaptation and fracture resistance of CAD/CAM-fabricated ZLS molar crowns. Dent Mater . 2015;31(11):1363-1369.\nZesewitz TF, Knauber AW, Nothdurft FP. Fracture resistance of a selection of full-contour all-ceramic crowns: an in vitro study. Int J Prosthodont. 2014;27(3):264-266.\nKwon S, Lawson NC, Burgess JO, Morris GP. Fracture load of zirconia and lithium disilicate crowns [abstract]. J Dent Res. 2018;97(spec iss A). Abstract 247.\nNakamura K, Mouhat M, Nergård JM, et al. Effect of cements on fracture resistance of monolithic zirconia crowns. Acta Biomater Odontol Scand. 2016;2(1):12-19.\nSimon JF, de Rijk WG, Hill J, Hill N. Tensile bond strength of ceramic crowns to dentin using resin cements. Int J of Comput Dent. 2011;14(4):309-319.\nHeintze SD. Crown pull-off test (crown retention test) to evaluate the bonding effectiveness of luting agents. Dent Mater. 2010;26(3):193-206.\nShimazu K, Karibe H, Ogata K. Effect of artificial saliva contamination on adhesion of dental restorative materials. Dent Mater J. 2014;33(4):545-550.\nBernades Kde O, Hilgert LA, Ribeiro AP, et al. The influence of hemostatic agents on dentin and enamel surfaces and dental bonding: a systematic review. J Am Dent Assoc. 2014;145(11):1120-1128.\nKious AR, Roberts HW, Brackett WW. Film thicknesses of recently introduced luting cements. Journal of Prosthetic Dentistry. 2009; 101: 189-192.\nDiaz-Arnold AM, Vargas MA, Haselton DR. Current status of luting agents for fixed prosthodontics. Journal of Prosthetic Dentistry. 1999; 81: 135-141.\nLadha K, Verma M. Conventional and contemporary luting cements: an overview. Journal of Indian Prosthodontic Society. 2010; 10: 79-88.\nPissaia JF, Correr GM, Gonzaga CC, da Cunha LF. Influence of shade, curing mode, and aging on the color stability of resin cements. Braz J Oral Sci. 2015;14(4):272-275\nSimon JF, de Rijk W. Dental cements. Inside Dentistry. 2006;2(2):42-47.\nSmith DS, Vandewalle KS, Whisler G. Color stability of composite resin cements. Gen Dent. 2011;59(5):390-394\nHekimoglu C, Anil N, Etikan I. Effect of accelerated aging on the color stability of cemented laminate veneers. International Journal of Prosthodontics. 2000; 13: 29-33.\nTurgut S, Bagis B. Colour stability of laminate veneers: an in vitro study. Journal of Dentistry. 2011; 39: e57-e64.\nTsujimoto A, Barkmeier WW, Takamizawa T, et al. Relationship between simulated gap wear and generalized wear of resin luting cements. Oper Dent. 2017;42(5):E148-E158\nPereira SG, Fulgencio R, Nunes TG, Toledano M, Osorio R, et al. Effect of curing protocol on the polymerization of dual-cured resin cements. Dental Materials. 2010; 26: 710-718.\nAguiar TR, Di Francescantonio M, Ambrosano GM, Giannini M. Effect of curing mode on bond strength of self-adhesive resin luting cements to dentin. Journal of Biomedical Materials Research Part B: Applied Biomaterials. 2010; 93: 122-127.\nCadenaro M, Navarra CO, Antoniolli F, Mazzoni A, Di Lenarda R, et al. The effect of curing mode on extent of polymerization and microhardness of dual-cured, self-adhesive resin cements. American Journal of Dentistry. 2010; 23: 14-18.\nBehr M, Rosentritt M, Wimmer J, Lang R, Kolbeck C, et al. Self-adhesive resin cement versus zinc phosphate luting material: a prospective clinical trial begun 2003. Dental Materials. 2009; 25: 601-604.\nRadovic I, Monticelli F, Goracci C, Vulicevic ZR, Ferrari M. Self-adhesive resin cements: a literature review. Journal of Adhesive Dentistry. 2008; 10: 251-258.\nMadruga FC, Ogliari FA, Ramos TS, et al. Calcium hydroxide, pH-neutralization and formulation of model selfadhesive resin cements. Dent Mater. 2013;29(4):413-418.\nFerracane JL, Stansbury JW, Burke FJ. Self-adhesive resin cements - chemistry, properties and clinical considerations. J Oral Rehabil. 2011;38(4):295-314.\nWeiser F, Behr M. Self-adhesive resin cements: a clinical review. J Prosthodont. 2015;24(2):100-108.\nViotti RG, Kasaz A, Pena CE, et al. Microtensile bond strength of new self-adhesive luting agents and conventional multistep systems. J Prosthet Dent. 2009;102(5):306-312.\nRippe MP, Amaral R, Oliveira FS, et al. Evaluation of tensile retention of Y-TZP crowns cemented on resin composite cores: effect of the cement and Y-TZP surface conditioning. Oper Dent. 2015;40(1):E1-E10\nHikita K, Van Meerbeek B, De Munck J, et al. Bonding effectiveness of adhesive luting agents to enamel and dentin. Dent Mater. 2007;23(1):71-80.\nRodrigues RF, Ramos CM, Francisconi PA, Borges AF. The shear bond strength of self-adhesive resin cements to dentin and enamel: an in vitro study. J Prosthet Dent. 2015;113(3):220-227.\nGomes G, Gomes O, Reis A, Gomes J, Loguercio A, et al. Effect of operator experience on the outcome of fiber post cementation with different resin cements. Operative Dentistry. 2013; 38: 555-564.\nFrankenberger R, Lohbauer U, Roggendorf MJ, et al. Selective enamel etching reconsidered: better than etch-andrinse and self-etch? J Adhes Dent. 2008;10(5):339-344.\nGleave CM, Chen L, Suh BI. Calcium & fluoride recharge of resin cements. Dent Mater. 2016;(32S):e26.\nChen L, Gleave CM, Suh BI. New self-adhesive resin cement with alkaline pH. J Dent Res. 2017; 96(A):286.\nFlury S, Lussi A, Hickel R, Ilie N. Light curing through glass ceramics: effect of curing mode on micromechanical properties of dual-curing resin cements. Clin Oral Investig. 2014;18(3):809-818.\nÖzcan M, Bernasconi M. Adhesion to zirconia used for dental restorations: a systematic review and meta-analysis. J Adhes Dent. 2015;17(1):7-26.\nZhao L, Jian YT, Wang XD, Zhao K. Bond strength of primer/cement systems to zirconia subjected to artificial aging. J Prosthet Dent. 2016;116(5):790-796.\nSuh BI. Principles of Adhesion Dentistry: A Theoretical and Clinical Guide for Dentists. Newtown, PA: AEGIS Publications; 2013\nChen L, Shen H, Suh BI. Effect of incorporing BisGMA resin on bonding properties of silane and zirconia primer. J Prosthet Dent. 2013;110(5):402-407.\nLuthra R, Kaur P. An insight into current concepts and techniques in resin bonding to high strength ceramics. Aust Dent J. 2015 Aug 13. doi:10.1111/adj.12365\nYang B, Lange-Jansen HC, Scharnberg M, et al. Influence of saliva contamination on zirconia ceramic bonding. Dent Mater. 2008;24(4):508-513.\nKim DH, Son JS, Jeong SH, et al. Efficacy of various cleaning solutions on saliva-contaminated zirconia for improved resin bonding. J Adv Prostho\nCopyright (c) 2019 The authors\nThis work is licensed under a Creative Commons Attribution 4.0 International License.\nAll articles are published in open-access and licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0). Hence, authors retain copyright to the content of the articles.\nCC BY 4.0 License allows content to be copied, adapted, displayed, distributed, re-published or otherwise re-used for any purpose including for adaptation and commercial use provided the content is attributed.", "domain": "chemistry", "round": 3} +{"url": "https://www.michfb.com/mi/policy_and_politics/policy_development/contamination_and_legacy_pollution/", "date": "2019-04-24T02:41:47Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-18/segments/1555578624217.55/warc/CC-MAIN-20190424014705-20190424040037-00025.warc.gz", "language_score": 0.9303432703018188, "token_count": 407, "dump": "CC-MAIN-2019-18", "global_id": "webtext-fineweb__CC-MAIN-2019-18__0__25274098", "lang": "en", "text": "Michigan’s industrial history has provided both opportunity for technological advancement and growing concerns over soil and water pollution. Farmers face challenges, with no easy answers, when contamination is found on or near their farms. A new state initiative to investigate Perfluoroalkyl and Polyfluoroalkyl substances (PFAS) is a prime example. Used for decades in everything from firefighting foam to stain-resistant and non-stick coatings, this class of chemicals moves through surface and groundwater and does not break down easily.\nWith research suggesting health risks caused by exposure to these chemicals, Michigan adopted new federal drinking water standards of 70 parts per trillion, and is testing municipal water systems for PFAS. Still unknown, however, is whether – or how much – PFAS in the soil or irrigation water could be taken up by crops, or what concentration might endanger livestock or pass into meat, eggs, or milk. More research is needed to establish what farmers need to know about these and many other chemicals.\nAdopting practices more familiar to industry than farming may provide some protection: Michigan law protects landowners from liability if they did not cause the contamination and they either: 1) purchased the property before 1995, or 2) perform and submit a Baseline Environmental Assessment. This includes protection from clean-up costs if the contamination must be remediated. However, the landowner cannot increase exposure to the contamination, which may affect the farmer’s ability to do activities like installing drain tile if the tile carries contamination off the property. It also does not address other questions about risks to farms and food. Farmers need thorough research, science-based regulation, and proactive action to not only protect themselves, but to help protect human and environmental health.\nLaura Campbell | 517-679-5332\nMFB: #84 Nonpoint Source Pollution and Watershed Management\nAFBF: #505 Hazardous and Nuclear Waste Management\nMichigan Guidance on Environmental Contamination\nPFAS Information from Michigan’s Action Response Team", "domain": "chemistry", "round": 3} +{"url": "https://www.c2change.org/tag/do-electronic-water-descalers-work/", "date": "2023-12-09T04:29:26Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100800.25/warc/CC-MAIN-20231209040008-20231209070008-00154.warc.gz", "language_score": 0.9523336887359619, "token_count": 332, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__124282218", "lang": "en", "text": "An electronic water scaler can be a great addition to your home. This article explains why an electronic water descaler is a great addition to any home safety plan.\nWhat is a website electronic water scaler?\nAn electronic water scaler is used to remove limescale deposits from hard water. This affects approximately 60% of UK homes. Magnetic descalers and ion-exchange softeners are more expensive and less effective than other methods.\nYou can effectively reduce the “scum” in your sinks and baths.\nUse chemical to soften water\nLow cost solution.\nAssists in maintaining the pipework of the house, such as boilers, storage tanks and radiators, as well washing machines and showers.\nIt is easy to install. There are no moving parts.\nIndicates faults in the internal or external systems.\nDoes not have any adverse effects on the chemical composition of water.\nYou can enjoy the health benefits of soft water (e.g. It is gentler on the skin\nAvoid using harmful cleaning products.\nReduced heating costs can be achieved by not using more fuel. Limescale reduces flow.\nWhen will I start to see the benefits?\nThe unit will soften water as soon as it’s installed. This will prevent limescale buildup from ever occurring. It takes longer to get rid of deposits that have been built up over years, but they will eventually disappear when the water is softer. Although it can take several months to remove limescale deposits due to the fact that some of them have been building up for decades, it is relatively easy.", "domain": "chemistry", "round": 3} +{"url": "https://www.ars.usda.gov/research/publications/publication/?seqNo115=226683", "date": "2023-03-28T05:40:28Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-14/segments/1679296948765.13/warc/CC-MAIN-20230328042424-20230328072424-00508.warc.gz", "language_score": 0.8995358347892761, "token_count": 728, "dump": "CC-MAIN-2023-14", "global_id": "webtext-fineweb__CC-MAIN-2023-14__0__135225939", "lang": "en", "text": "Submitted to: Meeting Abstract\nPublication Type: Abstract Only\nPublication Acceptance Date: 3/31/2008\nPublication Date: 10/11/2008\nCitation: Klein, M., Grusak, M.A. 2008. Survey of ferric reductase transcription and activity in Pisum sativum accessions [abstract]. XIV International Symposium on Iron Nutrition and Interactions in Plants, October 11-16, 2008, Beijing, China. p. 81.\nTechnical Abstract: Iron (Fe) is an essential element for the growth of plants. While Fe is not limiting in most soils (it makes up approximately 5% of total soil minerals), Fe availability to plants in aerated, calcareous soils near neutral or basic pH can be severely limited as Fe oxidizes to form less soluble ferric hydroxide precipitates. Under conditions of low Fe availability, dicot and non-graminaceous monocot plants induce a three-part Fe accumulation response to mobilize Fe within the rhizosphere and move it into the roots, referred to as Strategy I. Strategy I includes acidification of the rhizosphere via proton pump activation, reduction of Fe(III) to Fe2+ through a plasma membrane bound ferric reductase, and increased uptake of Fe2+ by Fe2+ transporters localized to the plasma membrane of the root epidermis. Physiological studies in pea (Pisum sativum) suggest that the reduction of Fe is the rate-limiting physiological process in Fe acquisition for Strategy I plants. In order to understand the regulation of ferric reductase in plants, a number of studies have been conducted with the bronze (brz) and degenerative leaflet (dgl) pea mutants. These pea mutants display iron deficient root phenotypes (high levels of ferric reductase activity, increased Fe transport into root tissue) even under iron-replete growing conditions, leading to excessive iron accumulation in shoot tissue. Grafting experiments with these mutant lines demonstrate constitutive expression of FRO1, the ferric reductase in roots of plants, suggesting that shoot-based signals play a role in the regulation of Fe uptake in roots. Additional work in Arabidopsis suggests that both transcriptional and translational regulation play a role in the activity of ferric reductase. In order to further dissect the regulation between ferric reductase transcription and activity, and to take advantage of the iron homeostasis mutants available in pea, we have undertaken a survey of pea accessions to characterize ferric reductase transcription and activity. Thirty different pea accessions representing genotypes from a worldwide range of environmental locations were obtained from the USDA Agricultural Research Service's Pisum Germplasm Collection. These plants were grown under low and high Fe conditions (0.5 and 15uM Fe(III)-EDDHA) and analyzed for root Fe reductase activity and FRO1 transcript abundance via quantitative RT-PCR. While transcript studies are still ongoing, initial reductase activity assays show variable activity both between and within pea accessions. The correlation between transcriptional FRO1 levels and ferric reductase activity under both low and high Fe media conditions will be shown and discussed as a means to modify or further understand Fe homeostasis and regulation at the whole plant level.", "domain": "chemistry", "round": 3} +{"url": "https://exosome-rna.com/facilitating-biomedical-research-creative-biolabs-cutting-edge-exosome-services/", "date": "2023-12-01T12:44:06Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100287.49/warc/CC-MAIN-20231201120231-20231201150231-00220.warc.gz", "language_score": 0.8914251923561096, "token_count": 731, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__220616107", "lang": "en", "text": "Creative Biolabs, a leading biotechnology company, stands at the forefront of innovation in exosome research, offering a diverse range of top-tier exosome-related services, including exosome purification, characterization, and labeling.\nExosomes have ignited a scientific revolution as remarkably promising nanoscale particles. These exosomes not only facilitate seamless intercellular communication but also hold tremendous potential in drug delivery, biomarker research, and early disease diagnosis, including cancer.\nCreative Biolabs’ exosome purification services equip researchers with an efficient means to procure high-quality exosome samples for their vital research and experimentation endeavors.\n“Our services entail the extraction of exosomes from various sources, such as cell culture media and bodily fluids, utilizing various separation techniques to yield exceptionally pure exosome samples,” elucidated the chief scientist at Creative Biolabs. “Moreover, we provide personalized services tailored to the specific requirements of individual research projects.”\nCreative Biolabs employs cutting-edge techniques aimed at augmenting exosome concentration and quality in their purification process. This includes the utilization of techniques such as ultracentrifugation and ultrafiltration, size-exclusion chromatography (SEC), and immune affinity capture.\nBesides, Creative Biolabs’ comprehensive exosome development platform not only purifies isolated exosomes but also characterizes them, leading to a profound understanding of exosome properties that propels subsequent therapeutic and diagnostic applications.\n“At Creative Biolabs, advanced characterization techniques expedite researchers’ experimental processes, breaking down research barriers,” added the scientist. “For example, our mass spectrometry-based exosome characterization enables both qualitative and quantitative chemical analysis of extracellular vesicles, allowing for an evaluation of protein, lipid, and metabolite compositions.”\nCreative Biolabs also employs various techniques to precisely define exosome characteristics, catering to diverse experimental requisites:\n* Nanoparticle Tracking Analysis: Employed by Creative Biolabs, this exceptionally sensitive method provides vivid visual insights into exosomes. It directly captures the scattering of light from exosomes or micro-vesicles suspended in liquid, delivering precise data.\n* Western Blotting: At Creative Biolabs, western blotting technology has been harnessed to meticulously detect the presence and gauge the expression level of specific single proteins on the surface of exosomes.\n* Tunable Resistive Pulse Sensing: This technique ensures remarkably accurate measurements of nanoparticle physicochemical properties, such as concentration, size, and surface charge.\n“Labeling and tracking of exosomes are indispensable not only for characterization but also for various research purposes. Creative Biolabs’ exosome labeling services offer multiple labeling methods, including fluorescent labeling, biotin labeling, and gold nanoparticle labeling.”\nThese methods can be chosen based on research requirements to ensure clear visibility of exosomes in experiments. Exosome labeling services offered by Creative Biolabs involve chemical labeling, biological tagging, and genetic engineering approaches, guaranteeing label stability and reliability.\nFor more exosome development services, please visit https://www.creative-biolabs.com/exosome/.\nAbout Creative Biolabs\nCreative Biolabs, an exceptional biotechnology company, plays a pivotal role in propelling innovation in the realm of exosome research. Additionally, it offers invaluable tools and resources to researchers across the fields of biology, biomedicine, and drug development.", "domain": "chemistry", "round": 3} +{"url": "https://www.brainscape.com/flashcards/exam-3-acid-base-balance-816497/packs/1478278", "date": "2018-12-17T10:33:01Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-51/segments/1544376828501.85/warc/CC-MAIN-20181217091227-20181217113227-00430.warc.gz", "language_score": 0.684170663356781, "token_count": 692, "dump": "CC-MAIN-2018-51", "global_id": "webtext-fineweb__CC-MAIN-2018-51__0__80078091", "lang": "en", "text": "Flashcards in Exam 3- Acid Base Balance Deck (17):\nWhat is going on during the Acid Base balance?\nCO2+H20--H2CO3 (bicarbonic acid)--H+ + HCO3- (bicarbonate)\nLUNGS and KIDNEYS works together to maintain homeostasis\nKidneys- metabolic (slow)\nWhat 3 arterial blood gas values maintain homeostasis?\n1. pH: 7.35-7.45\n2. PaC02: 35-45 (respiratory)\n3. HC03-: 22-26 (metabolic)\nWhere are ABG's located?\nLower than veins therefore analyze ABG's\nWhen should you check ABGs every hour?\nPt who overdosed on Aspirin\nInterpretation of ABG's: ROME\nRO- Respiratory Opposite\nIncreased pH, Decreased PaCo2- Respiratory Alkalosis\nDecreased pH, Increased PaCo2- Respiratory Acidosis\nME- Metabolic Equal\nIncreased pH, Increased HCO3-= Metabolic Alkalosis\nDecreased pH, Decreased HCO3-= Metabolic Acidosis\nWhat can cause compensated respiratory acidosis?\nLong standing respiratory insufficiency e.g- COPD chronic obstructive pulmonary disease\nWhat can cause respiratory acidosis?\nHYPOVENTILATION- CO2 builds up\nRESPIRATORY FAILURE: ASTHMA, EMPHESEMIA therefore pt TRAPS TOO MUCH CO2 in lungs and C02 expands causing resp. acidosis. BRONCHITIS\nNursing interventions for pt experiencing resp acidosis to help start breathing?\npercussion test, chest physiotherapy\nASSIST PT WITH THESE^\nWhat causes Respiratory Alkalosis?\nHYPERVENTILATION: exhaling too much C02 (getting rid of) because breathing too fast.\nCaused by: TRAUMA pt in shock or ventillator setting is inappropriate for pt in ICU\nNursing interventions for pt in respiratory alkalosis?\nHave pt breathe in PAPER BAG so that they can breathe in the CO2.\nPt breathe in a MASK\nREASSURANCE: person in car accident, child or someone injured therefore parent's breathing becomes RAPID..bring parent back to HOMEOSTASIS..breathe bitch breathe in a bag!\nWhat causes metabolic acidosis?\nWhat is the most common metabolic acidosis?\nDIABETIC KETOACIDOSIS- breakdown of fat in body, that process causes release of ketones (acidic, high) in diabetic pt. therefore ketones released in blood, which are highly acidic= metabolic acidosis!\nNursing interventions for metabolic acidosis?\nTake seizure percautions\nWhat causes Metabolic Alkalosis?\n1. ANTACIDS- excess Tums, alkaseltzer or antacid use excessively\n2. GASTRIC LOSS- e.g NG tube, loss of stomach fluid, HCL acid loss in stomach therefore shift to become alkalodic.\nEffects: VOMITING, POISONING, OVERDOSE", "domain": "chemistry", "round": 3} +{"url": "https://www.s-a-s.org/journal/viewer/abstract/2537/", "date": "2015-04-27T04:07:31Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2015-18/segments/1429246657041.90/warc/CC-MAIN-20150417045737-00082-ip-10-235-10-82.ec2.internal.warc.gz", "language_score": 0.9049178957939148, "token_count": 284, "dump": "CC-MAIN-2015-18", "global_id": "webtext-fineweb__CC-MAIN-2015-18__0__68305428", "lang": "en", "text": "The following is an abstract for the selected article. A PDF download of the full text of this article is available here. Members may download full texts at no charge. Non-members may be charged a small fee for certain articles.\nEvaluation of Disseminated Candidiasis on an Experimental Animal Model: A Fourier Transform Infrared Study\nVolume 61, Number 2 (Feb. 2007) Page 199-203\nDogan, Ayca; Ergen, Kivanc; Budak, Fatma; Severcan, Feride\nInvasive candidiasis, defined as candidemia and disseminated candidiasis, is the most common fungal infection in hospitalized patients. In the current study, we used Fourier transform infrared (FT-IR) spectroscopy as a rapid, non-perturbing technique to investigate the effects of disseminated candidiasis on mouse liver tissues at the molecular level. The results revealed that the infection caused compositional changes in the tissues by decreasing the lipid content and the ratio of the saturated lipids to unsaturated lipids. An increase in the lipid/protein ratio was also observed. In addition, investigation of the olefinic band at 3014 cm−1 showed that lipid peroxidation took place in the infected samples. These results indicate that FT-IR spectroscopy is a promising technique for the evaluation and diagnosis of disseminated candidiasis.", "domain": "chemistry", "round": 3} +{"url": "https://www.rcsb.org/structure/5M6D", "date": "2020-11-29T10:38:55Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-50/segments/1606141197593.33/warc/CC-MAIN-20201129093434-20201129123434-00484.warc.gz", "language_score": 0.8741052746772766, "token_count": 553, "dump": "CC-MAIN-2020-50", "global_id": "webtext-fineweb__CC-MAIN-2020-50__0__103521365", "lang": "en", "text": "Deciphering Key Residues Involved in the Virulence-promoting Interactions between Streptococcus pneumoniae and Human Plasminogen.Moreau, C., Terrasse, R., Thielens, N.M., Vernet, T., Gaboriaud, C., Di Guilmi, A.M.\n(2017) J Biol Chem 292: 2217-2225\n- PubMed: 28011643\n- DOI: 10.1074/jbc.M116.764209\n- Primary Citation of Related Structures:\n- PubMed Abstract:\nBacterial pathogens recruit circulating proteins to their own surfaces, co-opting the host protein functions as a mechanism of virulence. Particular attention has focused on the binding of plasminogen (Plg) to bacterial surfaces, as it has been shown ...\nBacterial pathogens recruit circulating proteins to their own surfaces, co-opting the host protein functions as a mechanism of virulence. Particular attention has focused on the binding of plasminogen (Plg) to bacterial surfaces, as it has been shown that this interaction contributes to bacterial adhesion to host cells, invasion of host tissues, and evasion of the immune system. Several bacterial proteins are known to serve as receptors for Plg including glyceraldehyde-3-phosphate dehydrogenase (GAPDH), a cytoplasmic enzyme that appears on the cell surface in this moonlighting role. Although Plg typically binds to these receptors via several lysine-binding domains, the specific interactions that occur have not been documented in all cases. However, identification of the relevant residues could help define strategies for mitigating the virulence of important human pathogens, such as Streptococcus pneumoniae (Sp). To shed light on this question, we have described a combination of peptide-spot array screening, competition and SPR assays, high-resolution crystallography, and mutational analyses to characterize the interaction between SpGAPDH and Plg. We identified three SpGAPDH lysine residues that were instrumental in defining the kinetic and thermodynamic parameters of the interaction. Altogether, the integration of the data presented in this work allows us to propose a structural model for the molecular interaction of the SpGAPDH-Plg complex.\nFrom the Institut de Biologie Structurale (IBS), Université Grenoble Alpes, Commissariat à l'Energie Atomique (CEA), CNRS, 38044 Grenoble, France firstname.lastname@example.org.", "domain": "chemistry", "round": 3} +{"url": "https://www.procurementresource.com/resource-center/heavy-alkyl-benzene-hab-price-trends", "date": "2022-08-15T21:54:51Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882572212.96/warc/CC-MAIN-20220815205848-20220815235848-00542.warc.gz", "language_score": 0.887223482131958, "token_count": 379, "dump": "CC-MAIN-2022-33", "global_id": "webtext-fineweb__CC-MAIN-2022-33__0__156582568", "lang": "en", "text": "Procurement Resource provides latest prices of Heavy Alkyl Benzene. Each price database is tied to a user-friendly graphing tool dating back to 2014, which provides a range of functionalities: configuration of price series over user defined time period; comparison of product movements across countries; customisation of price currencies and unit; extraction of price data as excel files to be used offline.\nProcurement Resource provides prices of Heavy Alkyl Benzene for several regions around the globe, which are as follows:\nAbout Heavy Alkyl Benzene:\nHeavy Alkyl Benzene (HAB) is a byproduct formed during the production process of linear alkyl benzene (LAB). It’s a clear and limpid noncorrosive liquid. It is used as heat transfer oil and lubricating greases. Heavy Alkyl Benzene is the primary raw material for lubricants, metal surface treatment products, including galvanic and electroplating products.\nThe UOP (Universal Oil Products) process involves pre-fraction, hydro-treating, extraction, dehydrogenation, and alkylation to produce linear alkyl benzene, where Heavy Alkyl Benzene is formed as a byproduct.\nNote: Our supplier search experts can assist your procurement teams in compiling and validating a list of suppliers indicating they have products, services, and capabilities that meet your company's needs.\nThe displayed pricing data is derived through weighted average purchase price, including contract and spot transactions at the specified locations unless otherwise stated. The information provided comes from the compilation and processing of commercial data officially reported for each nation (i.e. government agencies, external trade bodies, and industry publications).", "domain": "chemistry", "round": 3} +{"url": "https://heika-research.de/en/research/advanced-imaging-platform-aip", "date": "2020-11-26T04:25:32Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-50/segments/1606141186414.7/warc/CC-MAIN-20201126030729-20201126060729-00618.warc.gz", "language_score": 0.803123950958252, "token_count": 305, "dump": "CC-MAIN-2020-50", "global_id": "webtext-fineweb__CC-MAIN-2020-50__0__174351424", "lang": "en", "text": "The Research Bridge AIP establishes an integrated research program on advancing imaging methods including optical, electron and x-ray modalities. The platform also covers correlative approaches aimed at combining these modalities to extend the structural and temporal information that can be extracted from an individual sample under study. Important aspects in the framework of the “AIP” are technical advances of the various imaging techniques, development of novel contrast agents, advancements of preparation techniques and image data processing software for the different imaging modalities and combinations thereof.\nAdvanced Imaging Platform (AIP)\nHEiKA-Projects of this research bridge\n- Prof. Dr. Thomas Kuner / Dr. Frank BiedermannIn vitro and in vivo Monitoring of Dopamine Levels in Neural Tissues using Novel Zeolite-based Chemosensors\n- Prof. Dr. Carmen Wängler / Prof. Dr. Stefan Bräse\n- Dr. Iordania Constantinou / Dr. Dario MagerHigh-throughput selective cell isolation based on imprinted microfluidics and fluorescence microscopy\n- Prof. Dr. Heike Allgayer / Prof. Dr. Hans-Achim WagenknechtSynthesis of single cell, single molecule RNA probes for the detection of enogenous microRNAs in human cancer to dentify metastatically relevant cance cell fractions in heterogenous tumors\n- Prof. Dr. Joachim Wittbrodt / Prof. Dr. Tilo Baumbach", "domain": "chemistry", "round": 3} +{"url": "http://www.avt.rwth-aachen.de/AVT/index.php?id=541&L=1&Nummer=BioVT-2009-15", "date": "2013-06-19T00:46:40Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2013-20/segments/1368707437545/warc/CC-MAIN-20130516123037-00016-ip-10-60-113-184.ec2.internal.warc.gz", "language_score": 0.8858116865158081, "token_count": 648, "dump": "CC-MAIN-2013-20", "global_id": "webtext-fineweb__CC-MAIN-2013-20__0__169724116", "lang": "en", "text": "Robert Huber, Daniel Ritter, Till Hering, Ann-Kathrin Hillmer, Frank Kensy, Carsten Müller, Le Wang, Jochen Büchs:\nRobo-Lector - a novel platform for automated high-throughput cultivations in microtiter plates with high information content\nMicrobial Cell Factories, 2009, 8:42\nBackground: In industry and academic research, there is an increasing demand for flexible automated microfermentation platforms with advanced sensing technology. However, up to now, conventional platforms cannot generate continuous data in high-throughput cultivations, in particular for monitoring biomass and fluorescent proteins. Furthermore, microfermentation platforms are needed that can easily combine cost-effective, disposable microbioreactors with downstream processing and analytical assays. Results: To meet this demand, a novel automated microfermentation platform consisting of a BioLector and a liquid-handling robot (Robo-Lector) was sucessfully built and tested. The BioLector provides a cultivation system that is able to permanently monitor microbial growth and the fluorescence of reporter proteins under defined conditions in microtiter plates. Three examplary methods were programed on the Robo-Lector platform to study in detail high-throughput cultivation processes and especially recombinant protein expression. The host/vector system E. coli BL21(DE3) pRhotHi-2-EcFbFP, expressing the fluorescence protein EcFbFP, was hereby investigated. With the method 'induction profiling' it was possible to conduct 96 different induction experiments (varying inducer concentrations from 0 to 1.5 mM IPTG at 8 different induction times) simultaneously in an automated way. The method 'biomass-specific induction' allowed to automatically induce cultures with different growth kinetics in a microtiter plate at the same biomass concentration, which resulted in a relative standard deviation of the EcFbFP production of only ± 7%. The third method 'biomass-specific replication' enabled to generate equal initial biomass concentrations in main cultures from precultures with different growth kinetics. This was realized by automatically transferring an appropiate inoculum volume from the different preculture microtiter wells to respective wells of the main culture plate, where subsequently similar growth kinetics could be obtained. Conclusion: The Robo-Lector generates extensive kinetic data in high-throughput cultivations, particularly for biomass and fluorescence protein formation. Based on the non-invasive on-line-monitoring signals, actions of the liquid-handling robot can easily be triggered. This interaction between the robot and the BioLector (Robo-Lector) combines high-content data generation with systematic high-throughput experimentation in an automated fashion, offering new possibilities to study biological production systems. The presented platform uses a standard liquid-handling workstation with widespread automation possibilities. Thus, high-throughput cultivations can now be combined with small-scale downstream processing techniques and analytical assays. Ultimately, this novel versatile platform can accelerate and intensify research and development in the field of systems biology as well as modelling and bioprocess optimization.", "domain": "chemistry", "round": 3} +{"url": "https://pubag.nal.usda.gov/catalog/5432941", "date": "2019-10-23T01:09:19Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-43/segments/1570987826436.88/warc/CC-MAIN-20191022232751-20191023020251-00318.warc.gz", "language_score": 0.9155661463737488, "token_count": 453, "dump": "CC-MAIN-2019-43", "global_id": "webtext-fineweb__CC-MAIN-2019-43__0__101004103", "lang": "en", "text": "Jump to Main Content\nProteomic analysis of pakchoi leaves and roots under glycine–nitrogen conditions\n- Wang, Xiaoli, Tang, Dongmei, Huang, Danfeng\n- Plant physiology and biochemistry 2014 v.75 pp. 96-104\n- Brassica rapa subsp. chinensis, adenosine triphosphate, antioxidant activity, cultivars, defense mechanisms, electron transport chain, energy, hydroponics, image analysis, leaves, nitrate nitrogen, photosynthesis, plant adaptation, proteins, proteomics, ribulose-bisphosphate carboxylase, roots\n- The physiological and differential proteomic responses of pakchoi leaves and roots to glycine–nitrogen (Gly–N) treatments were determined. Two pakchoi (Brassica campestris ssp. chinensis L. Makino. var. communis Tsen et Lee) cultivars, ‘Huawang’ and ‘Wuyueman’, were grown under sterile hydroponic conditions with different N forms (Gly–N and nitrate–N). Gly–N-treated pakchoi exhibited decreased fresh weights, total N uptake, leaf areas, and net photosynthetic rates than those treated with nitrate–N. Differentially regulated proteins were selected after image analysis and identified using MALDI-TOF MS. A total of 23 proteins was up- or down-regulated following Gly–N treatment. These spots are involved in several processes, such as energy synthesis, N metabolism, photosynthesis, and active antioxidant defense mechanisms, that could enhance plant adaptation to Gly–N. The superior Gly tolerance of ‘Huawang’ was predominantly associated with a less severe down-regulation of proteins that are involved in the electron transport chain and N metabolism. Other factors could include less ribulose-1,5-bisphosphate carboxylase/oxygenase turnover or a higher up-regulation of stress defense proteins. These characteristics demonstrated that maintaining ATP synthesis, N metabolism, photosynthesis, and active defense mechanisms play a critical role in pakchoi adaptation to Gly–N.", "domain": "chemistry", "round": 3} +{"url": "https://cvlewimanunggal.indonetwork.co.id/product/llysine-hcl-99-ex-cheil-jedang-2107310", "date": "2019-11-14T05:11:58Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-47/segments/1573496667945.28/warc/CC-MAIN-20191114030315-20191114054315-00282.warc.gz", "language_score": 0.8265886306762695, "token_count": 359, "dump": "CC-MAIN-2019-47", "global_id": "webtext-fineweb__CC-MAIN-2019-47__0__188849975", "lang": "en", "text": "L-Lysine HCL 99%\nLysine is a key nutrient related to the production performance and considered as the first- or second-limiting amino acid in a typical corn-soybean based diet for most species. Currently, the use of free lysine is considered as an environment friendly tool to reduce dietary protein levels while maintaining growth performance.\nCJ L-Lysine HCl Feed Grade is produced by microbial fermentation (Corynebacterium Glutamicum) with natural raw materials (raw sugar, beet molasses, cane molasses, or SOD) which helps to improve performance of animals and to lower users' production costs.\nThis product is used only for animals.\nA pale brownish free flowing crystalline powder\nProduct Identification and Specifications\n- Chemical Composition : L-Lysine Monohydrochloride 99%\n- Purity (Dry Basis) : Not less than 99%\n- Solubility in water : 642g/ l ( 30° C)\n- Bulk Density : 0.670 ~ 0.750 g/ ml\n- Shelf life : 2 years\n- Moisture : Not more than 1%\n- Residue on Ignition : Not more than 0.3%\n- Heavy metals : Not more than 10 ppm\n- Arsenic : Not more than 1 ppm\n- Lysine Content : Not less than 79%\n- Crude Protein Content : Not less than 94.62%\n- GE: Average 4,860 Kcal / kg\n- Swine Metabolizable Energy: 4,150 Kcal / Kg\n- Poultry Metabolizable Energy: 3,890 Kcal / Kg", "domain": "chemistry", "round": 3} +{"url": "https://scholarworks.unist.ac.kr/handle/201301/22974", "date": "2020-02-27T20:38:03Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-10/segments/1581875146809.98/warc/CC-MAIN-20200227191150-20200227221150-00468.warc.gz", "language_score": 0.8163142204284668, "token_count": 415, "dump": "CC-MAIN-2020-10", "global_id": "webtext-fineweb__CC-MAIN-2020-10__0__84015755", "lang": "en", "text": "Direct Fabrication of Flexible Ni Microgrid Transparent Conducting Electrodes via Electroplated Metal Transfer\nCited 0 times inCited 0 times in\n- Direct Fabrication of Flexible Ni Microgrid Transparent Conducting Electrodes via Electroplated Metal Transfer\n- Park, Jeonghwan; Lee, Kangmin; Um, Han-Don; Kim, Ka-Hyun; Seo, Kwanyong\n- Issue Date\n- ADVANCED MATERIALS TECHNOLOGIES, v.3, no.1, pp.1700213\n- A cost-effective process is reported for fabricating flexible transparent conducting electrodes (TCEs) through the use of a reusable silicon master mold with a microgrid patterned Ag/Cr-metal double layer. Flexible TCEs can be simply produced via metal electroplating on the master mold followed by metal transfer onto a flexible polymer substrate. Nickel (Ni), an inexpensive metal, is used as the TCE material in this study, allowing low-cost TCE fabrication. The fabricated flexible Ni TCEs exhibit excellent optical and electrical properties (sheet resistance of 6.1 Omega sq(-1) with 96% transmittance) along with outstanding mechanical flexibility with no significant change in sheet resistance after 1000 bending cycles at a bending radius of 4 mm. A touch screen panel is also successfully demonstrated using an Ni microgrid TCE to confirm the practical applicability of these TCEs. The results indicate that the proposed flexible Ni microgrid TCEs have potential for rapid commercialization because of their high optoelectronic performance, low cost, and facile fabrication process.\n- Appears in Collections:\n- ECHE_Journal Papers\n- Files in This Item:\n- There are no files associated with this item.\ncan give you direct access to the published full text of this article. (UNISTARs only)\nShow full item record\nItems in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.", "domain": "chemistry", "round": 3} +{"url": "https://www.e-aircraftsupply.com/products/lubricant/16672/Tribolube-F171", "date": "2018-07-22T22:20:13Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-30/segments/1531676594018.55/warc/CC-MAIN-20180722213610-20180722233610-00079.warc.gz", "language_score": 0.936866819858551, "token_count": 309, "dump": "CC-MAIN-2018-30", "global_id": "webtext-fineweb__CC-MAIN-2018-30__0__4123702", "lang": "en", "text": "Features and Specifications\nA good quality lubricant reduces friction and wear, dissipates heat, keeps out dirt, and prevents rust formation. It must provide good \"boundary layer\" lubrication, and be thin enough to get between moving parts, and once there, it must be thick enough to separate them with a slippery oil film. This oil film must be strong enough to provide full-film \"hydrodynamic\" lubrication between moving parts such as bearings, screw actuators, etc. It must also act as a kind of floating seal, filling in the microscopic imperfections in moving surfaces with a thin film of lubricant. If it is too thin, under shock or extreme loads it will not separate moving surfaces. If it is too thick, it cannot squeeze between the moving parts to provide proper lubrication. If either extreme exists, friction and wear occurs; accumulating wear debris escalates wear until failure occurs. Heat is generated between moving parts in machines, even though they are lubricated. Some greases can reduce the operating temperatures of bearings , gears, or other moving parts by having better EP and anti-wear properties thereby reducing the metal to metal contact and the associated heat. Grease lubricants also work as a seal, keeping out dirt and other foreign matter, thus preventing damage to the bearing and contact surfaces. The effect of rust or corrosion on unprotected metal can readily be understood. A lubricating film on moving parts protects them from this damage by preventing contact with air, moisture or other corrosive agents thereby increasing useful life.", "domain": "chemistry", "round": 3} +{"url": "https://www.matec-conferences.org/articles/matecconf/abs/2018/29/matecconf_spbwosce2018_03021/matecconf_spbwosce2018_03021.html", "date": "2021-06-19T12:52:59Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-25/segments/1623487648194.49/warc/CC-MAIN-20210619111846-20210619141846-00556.warc.gz", "language_score": 0.8896358013153076, "token_count": 439, "dump": "CC-MAIN-2021-25", "global_id": "webtext-fineweb__CC-MAIN-2021-25__0__109072865", "lang": "en", "text": "MATEC Web Conf.\nVolume 170, 2018International Science Conference SPbWOSCE-2017 “Business Technologies for Sustainable Urban Development”\n|Number of page(s)||5|\n|Section||Engineering Systems and Building Materials|\n|Published online||13 June 2018|\nThe clays after heat treatment as the concrete active mineral additive\nMoscow State University of Civil Engineering, Yaroslavskoe shosse, 26, Moscow, 129337, Russia\n* Corresponding author: email@example.com\nActive mineral additives are one of the most common components of cement systems now. They are entered cements of increase in extent of hydration, the directed formation of structure of a cement stone from more stable hydrate phases of the lowered basicity, for the purpose of improvement of construction and technical properties of cements, by cutting of costs of fuel raw material resources for their production, giving to cements of some specific properties. In work the possibility of use as active mineral additives not only the granulated slags, but also local clays which industrially can give certain puzzolan properties are considered. It is proved that heat treatment of clay breeds significantly increases their puzzolan activity that does them suitable for use as active mineral additive instead of the domain granulated slag by production of the portland cement.\n© The Authors, published by EDP Sciences, 2018\nThis is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (http://creativecommons.org/licenses/by/4.0/).\nCurrent usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.\nData correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.\nInitial download of the metrics may take a while.", "domain": "chemistry", "round": 3} +{"url": "https://offgridsurvival.com/corpus-christi-texas-residents-warned-not-use-water-back-flow-incident-contaminates-city-water/", "date": "2020-07-12T20:19:05Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-29/segments/1593657139167.74/warc/CC-MAIN-20200712175843-20200712205843-00432.warc.gz", "language_score": 0.9604828357696533, "token_count": 584, "dump": "CC-MAIN-2020-29", "global_id": "webtext-fineweb__CC-MAIN-2020-29__0__213116588", "lang": "en", "text": "Over 320,000 residents in the city of Corpus Christi, Texas have been told not to use their tap water after two “unknown chemicals” made their way into the city’s water systems.\nAccording to Corpus Christi city officials an unknown chemical substance contaminated the city’s drinking water in what they are calling a “back-flow incident.” Interestingly, we have reported numerous times in the past how susceptible our nation’s water systems are to these back-flow incidents. In one of these reports, we detailed how water officials in Atlanta, Georgia showed how easily terrorists could release chemicals and biological agents into the water system using a typical city fire hydrant, and a process known as backflow.\nIn an official statement, the city warned residents not to drink, wash, or brush their teeth with any city water. They warned that boiling, freezing, filtering, adding chlorine or other disinfectants, or letting the water stand will not make the water safe.\nPart of the statement read:\nLate today an unknown chemical substance may have contaminated the City of Corpus Christi drinking water due to a recent back-flow incident in the industrial district. In an abundance of caution and until results can confirm water safety, the City is issuing an avoid tap water usage until further notice. The City is working the incident with industry, state regulators and consultants to correct the situation as quickly as possible.\nAccording to city spokeswoman Kim Womack, the substance is thought to be an oil-based petroleum chemical, but Womack declined to say exactly what that chemical was. Womack said the city is working with the Texas Commission on Environmental Quality and the Centers for Disease Control.\nMayor Dan McQueen told local press that the city’s system, regarding disinfectant, did not fail. City officials think the chemicals were introduced to the system through a valve in the city’s industrial district. The potential contamination was discovered when an industrial property reported a sheen in the water when someone at the property was washing their hands. That happened before 6 p.m. on Wednesday. The city is looking at two “petroleum based” chemicals, but officials are not saying which ones or where the first call came from.\nWithin minutes of the news, stores throughout Corpus Christi were flooded by panicked residents who quickly wiped out all local bottled water supplies.\n— Gabe Hernandez (@callergabe) December 15, 2016\nCrowds of residents are lined up at stores throughout the city, hoping to be the first ones to get water when emergency shipments are expected to arrive later in the day.\nTens of Thousands of Residents are waiting in long lines throughout the city waiting for water shipments.\n— Tim Archuleta (@CallerTim) December 15, 2016\n— CC (@CC76253242) December 15, 2016", "domain": "chemistry", "round": 3} +{"url": "http://academickarma.org/theme/metabolic_engineering", "date": "2018-08-15T06:48:35Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-34/segments/1534221209980.13/warc/CC-MAIN-20180815063517-20180815083517-00545.warc.gz", "language_score": 0.7064986228942871, "token_count": 825, "dump": "CC-MAIN-2018-34", "global_id": "webtext-fineweb__CC-MAIN-2018-34__0__216408187", "lang": "en", "text": "See other preprint channels in Biology.\nIf you believe a preprint is missing from this list it is possible that we have not yet indexed it. Please use search function to help us index it.\n|Preprint||Authors||Date||Reviews & Comments||Actions|\n|A persistence detector for metabolic network rewiring in an animal||2nd Aug 2018||Bookmark|\n|RAVEN 2.0: a versatile platform for metabolic network reconstruction and a case study on Streptomyces coelicolor||H. Wang...\nE. J. Kerkhoven\n|13th May 2018||Bookmark|\n|Genetic Optimization Algorithm for Metabolic Engineering Revisited||27th Mar 2018||Bookmark|\n|N-hydroxy-pipecolic acid is a mobile signal that induces systemic disease resistance in Arabidopsis||Y. C. Chen...\n|25th Mar 2018||Bookmark|\n|Automated high-quality reconstruction of metabolic networks from high-throughput data||D. Hartleb, C. J. Fritzemeier, M. Lercher||14th Mar 2018||Bookmark|\n|Limited uptake of essential amino acid is effective for cancer therapy in metabolic networks of integrated constraint-based models||T. Tamura||13th Mar 2018||Bookmark|\n|A Graph-Based Approach to Analyze Flux-Balanced Pathways in Metabolic Networks.||M. Arabzadeh, M. S. . M. S. Z. . S. Marashi||6th Feb 2018||Bookmark|\n|Harnessing a Novel P450 Fatty Acid Decarboxylase from Macrococcus caseolyticus for Microbial Biosynthesis of Odd Chain Terminal Alkenes||J. Lee, N. Niraula, C. T. Trinh||29th Jan 2018||Bookmark|\n|Enumerating all possible biosynthetic pathways from metabolic networks||A. Ravikrishnan, M. Nasre, K. Raman||Nov 2017||Bookmark|\n|Eukaryotically expressed encapsulins as orthogonal compartments for multiscale molecular imaging||F. Sigmund...\nG. G. Westmeyer\n|Cell-free prototyping strategies for enhancing the sustainable production of polyhydroxyalkanoates bioplastics||R. Kelwick...\nP. S. Freemont\n|MetQy: an R package to query metabolic functions of genes and genomes||A. Martinez-Vernon, F. Farrell, O. Soyer||Nov 2017||Bookmark|\n|Accelerating Evolutionary Hill Climbs in Parallel Turbidostats||C. N. Takahashi, L. Zaman, E. Klavins||Nov 2017||Bookmark|\n|Stringency of synthetic promoter sequences in Clostridium revealed and circumvented by tuning promoter library mutation rates||P. M. Mordaka, J. T. Heap||Nov 2017||Bookmark|\n|Uncovering cell-free protein expression dynamics by a promoter library with diverse strengths||S. G. Reyes, Y. Kuruma, S. Tsuda||Nov 2017||Bookmark|\n|Discovery and Evaluation of Biosynthetic Pathways for the Production of Five Methyl Ethyl Ketone Precursors||M. Tokic...\n|Functional pathways for metabolic network-based data analysis: the MetPath algorithm||G. Mattei...\nB. O. Palsson\n|A cell-free synthetic biochemistry platform for raspberry ketone production||S. J. Moore...\n|Gene set enrichment analysis using RNA-seq-based condition-specific metabolic networks||V. D. T. Tran...\n|Exploiting transcriptomic data in genome-scale metabolic networks: new insights into obesity||I. Granata...\nM. R. Guarracino", "domain": "chemistry", "round": 3} +{"url": "http://www.genetex.com/Synaptotagmin-I-antibody-Internal-GTX88461.html", "date": "2017-03-30T09:00:35Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-13/segments/1490218193288.61/warc/CC-MAIN-20170322212953-00634-ip-10-233-31-227.ec2.internal.warc.gz", "language_score": 0.8046169281005859, "token_count": 313, "dump": "CC-MAIN-2017-13", "global_id": "webtext-fineweb__CC-MAIN-2017-13__0__233835295", "lang": "en", "text": "|Full Name||synaptotagmin 1|\n|Product Description||Goat polyclonal antibody to Synaptotagmin 1|\n|Background||May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2. |\n|Synonyms||synaptotagmin I, SYT, DKFZp781D2042, SVP65, P65, synaptotagmin 1, SYT1, synaptotagmin1|\n|Cellular Localization||Synaptic vesicles and chromaffin granules. |\n|Specificity||This antibody is specific for Synaptotagmin I.|\n|Predicted Cross Reactivity species Predicted cross-reactivity:|\nPredicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.\nPlease note that we are only able to guarantee products to work in applications and species in which they have been tested.\n|Mouse, Rat, Dog, Bovine|", "domain": "chemistry", "round": 3} +{"url": "https://thesoapstore.net/content.php?x=systems", "date": "2018-07-20T00:36:14Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-30/segments/1531676591455.76/warc/CC-MAIN-20180720002543-20180720022543-00184.warc.gz", "language_score": 0.8500511050224304, "token_count": 614, "dump": "CC-MAIN-2018-30", "global_id": "webtext-fineweb__CC-MAIN-2018-30__0__210096557", "lang": "en", "text": "Probe Four Liquid Laundry System\n- A unique, two-detergent concept\n- Custom formula capability\n- Cost-effective problem solving\n- Dependable, automatic dispensing\nThe Laundry System that offers on-premises laundries unique linear zone formulation automatically at the touch of your laundry machine switch.\nThe Probe Four Laundry System features precision peristalic dispensing of two unique detergents, chlorine and a sour/soft combination product. Precision dispensing by the peristalic pumps ensures precise levels of products when they are needed as your linen moves through the various wash cycles. The system makes the job of laundering all types of linen safe, easy and convenient.\nLinear Zone Formulation: Probe Four Laundry System's Precision dispesing blends Quest and Edge detergents in your wash wheel, creating the linear zone formulation. Because the laundry detergent is a two-part system, it is versatile. It allows infinite blending in the wash wheel. It also gives each customer a tailor made detergent for specific requirements. This system's flexibility is the key to excellent results on all types of linen. What's more, it accomplishes it's job at a low cost.\nStain Remover: Low-odored, controlled release chlorine bleach.\nConditioner: QA combination product that gives the final touches to clean linen: a silky, soft feel; spring fresh fragrance; optical brightness; and a comfortable PH.\nSuper Clean Instant Load System\n- Automatic dispensing of high performance powders\n- Consistently stable chemical potency\n- Easy-to-handle, spill proof packaging\n- \"Closed\" system safety and convenience\nThe powder dispensing system that puts safety, convenience, reliability and efficiency first.\nThe Super Clean Instant Load System features revolutionary packaging. High performance powdered detergent is dispensed directly from the shipping container. This packaging eliminates waste, spills, misuse and clutter. Even the most unskilled employee can consistently produce sparkling ware with the Instant Load System.\nUnique plastic screen cap is attached to every plastic container. These containers dispense a 100% active, high performance detergent into your wash tank instantly. The Instant Load System can charge even the largest tank in seconds. It reduces costly over shot, long charge times and inconsistent results.\nUnlike costly solid or liquid detergents that blend water with powdered ingredients, the Super Clean Instant Load System Offers 100% active ingredients. This system contains stable chlorine for effective stain removal, emulsifiers for heavy soil and water conditioning agents that control water hardness.\nThe combination of advanced blending, chemistry and packaging lets you observe the dipensing process of the Instant Load System. At a glance, the dishmachine operator or a manager can see if the product is dispensing properly or if the dispenser needs filling.\nTo obtain the best possible results at the lowest possible cost, call Chemtron and ask about our Super Clean Instant Load System.\nProteus Dilution System", "domain": "chemistry", "round": 3} +{"url": "http://rappsilberlab.org/research/proteomics/", "date": "2019-06-20T14:56:07Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-26/segments/1560627999218.7/warc/CC-MAIN-20190620125520-20190620151520-00403.warc.gz", "language_score": 0.8116931915283203, "token_count": 610, "dump": "CC-MAIN-2019-26", "global_id": "webtext-fineweb__CC-MAIN-2019-26__0__28645672", "lang": "en", "text": "We are working on novel methods for identifying and quantifying the interactions and the accurate sites of interaction of proteins with other proteins, DNA and RNA. This makes use of chemical cross-linking to preserve non-covalent interactions for their analysis by mass spectrometry and novel computer algorithms to automatically interpret the mass spectrometric data. We are further developing our methods to address larger complexes, dynamic structures and to couple our results with other technologies such as modelling and cryo-electron microscopy. Ultimately, we aim to analyze chromatin, a large, fragile, insoluble and dynamic protein assembly that is unlikely accessible to structural analysis by current technologies any time soon.\n- Architecture of the RNA polymerase II-TFIIF complex revealed by cross-linking and mass spectrometry.\nChen ZA, Jawhari A, Fischer L, Buchen C, Tahir S, Kamenski T, Rasmussen M, Lariviere L, Bukowski-Wills JC, Nilges M, Cramer P, Rappsilber J.\nEMBO J. 2010 Feb 17;29(4):717-26.\nHigher-order multi-protein complexes such as RNA polymerase II (Pol II) complexes with transcription initiation factors are often not amenable to X-ray structure determination. Here, we show that protein cross-linking coupled to mass spectrometry (MS) has now sufficiently advanced as a tool to extend the Pol II structure to a 15-subunit, 670 kDa complex of Pol II with the initiation factor TFIIF at peptide resolution. This work establishes cross-linking/MS as an integrated structure analysis tool for large multi-protein complexes.\n- Implications for kinetochore-microtubule attachment from the structure of an engineered Ndc80 complex.\nCiferri C, Pasqualato S, Screpanti E, Varetti G, Santaguida S, Dos Reis G, Maiolica A, Polka J, De Luca JG, De Wulf P, Salek M, Rappsilber J, Moores CA, Salmon ED, Musacchio A.\nCell. 2008 May 2;133(3):427-39.\n- Structural analysis of multi-protein complexes by cross-linking, mass spectrometry and database searching.\nMaiolica A, Cittaro D, Borsotti D, Sennels L, Ciferri C, Tarricone C, Musacchio A, Rappsilber J.\nMol Cell Proteomics. 2007 Dec;6(12):2200-11.\n- A generic strategy to analyze the spatial organization of multi-protein complexes by cross-linking and mass spectrometry.\nRappsilber J, Siniossoglou S, Hurt EC, Mann M.\nAnal Chem. 2000 Jan 15;72(2):267-75.", "domain": "chemistry", "round": 3} +{"url": "https://www.mdpi.com/2075-4701/9/6/653", "date": "2019-08-19T09:57:10Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-35/segments/1566027314721.74/warc/CC-MAIN-20190819093231-20190819115231-00326.warc.gz", "language_score": 0.8629754185676575, "token_count": 561, "dump": "CC-MAIN-2019-35", "global_id": "webtext-fineweb__CC-MAIN-2019-35__0__229514819", "lang": "en", "text": "Effects of Nb Content on the Mechanical Alloying Behavior and Sintered Microstructure of Mo-Nb-Si-B Alloys\nAbstractDifferent from conventional Mo-Si-B-based alloys consisting of Moss, Mo3Si, and Mo5SiB2, Mo3Si-free Mo-Si-B-based alloys (Moss+Mo5Si3+Mo5SiB2 or Moss+Mo5SiB2) show great potentials for more excellent oxidation resistance and elevated temperature strength. In the present work, alloying element Nb was added to Mo-12Si-10B (at.%)-based alloy to suppress the formation of the Mo3Si phase. Mo-12Si-10B-xNb (x = 10, 20, 22, 24, 26, 28, 30, and 40) bulk alloys were fabricated using mechanical alloying followed by cold pressing and then sintering at 1773 K for 2 h. Effects of Nb content on the mechanical alloying behavior and then sintered microstructure were studied. The addition of Nb with an amount less than 30 at.% accelerated the mechanical alloying process, but 40 at.% Nb addition decreased the process due to excessive cold welding and high powder volume. For the sintered bulk alloy prepared from the mechanically alloyed powders milled for 30 h, a critical Nb content between 24 and 26 at.% was found to suppress Mo3Si production and γNb5Si3 phase formed in the alloys with the addition of Nb content more than 26 at.%. Prolongation of a prior milling process could facilitate the suppression of Mo3Si and delay the formation of niobium silicides. View Full-Text\nShare & Cite This Article\nYang, T.; Guo, X. Effects of Nb Content on the Mechanical Alloying Behavior and Sintered Microstructure of Mo-Nb-Si-B Alloys. Metals 2019, 9, 653.\nYang T, Guo X. Effects of Nb Content on the Mechanical Alloying Behavior and Sintered Microstructure of Mo-Nb-Si-B Alloys. Metals. 2019; 9(6):653.Chicago/Turabian Style\nYang, Tao; Guo, Xiping. 2019. \"Effects of Nb Content on the Mechanical Alloying Behavior and Sintered Microstructure of Mo-Nb-Si-B Alloys.\" Metals 9, no. 6: 653.\nNote that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.", "domain": "chemistry", "round": 3} +{"url": "http://www.bio-rad.com/en-us/prime-pcr-assays/assay/qhsacep0025465-primepcr-probe-assay-sftpa1-human", "date": "2019-02-17T18:34:35Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-09/segments/1550247482347.44/warc/CC-MAIN-20190217172628-20190217194628-00005.warc.gz", "language_score": 0.8313593864440918, "token_count": 276, "dump": "CC-MAIN-2019-09", "global_id": "webtext-fineweb__CC-MAIN-2019-09__0__42495539", "lang": "en", "text": "This is the amplicon context sequence in accordance with the minimum information for the publication of real-time quantitative PCR experiements (MIQE) guidelines. For more details, please refer to the following publication, \"Primer Sequence Disclosure: A Clarification of the MIQE Guidelines.\"\nReal-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.\nPrimePCR™ PreAmp for Probe Assay: SFTPA1, Human\nPrimePCR™ Template for Probe Assay: SFTPA1, Human\nThis gene encodes a lung surfactant protein that is a member of a subfamily of C-type lectins called collectins. The encoded protein binds specific carbohydrate moieties found on lipids and on the surface of microorganisms. This protein plays an essential role in surfactant homeostasis and in the defense against respiratory pathogens. Mutations in this gene are associated with idiopathic pulmonary fibrosis. Alternate splicing results in multiple transcript variants. [provided by RefSeq May 2010]\nProducts used to generate validation data:\nAmplification of cDNA generated from universal RNA.\nMelt curve analysis of above amplification.\nStandard curve generated using 20 million copies of template diluted 10 fold to 20 copies.", "domain": "chemistry", "round": 3} +{"url": "https://www.scholars.northwestern.edu/en/projects/next-generation-products-for-prevention-of-hiv-infection-in-women-5", "date": "2024-04-23T02:19:48Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712296818452.78/warc/CC-MAIN-20240423002028-20240423032028-00384.warc.gz", "language_score": 0.9036306142807007, "token_count": 592, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__40323556", "lang": "en", "text": "Development of novel long-acting systemic ARV delivery systems for the prevention of HIV acquisition in women Degradable subQ implants that show zero order release and degrade only after the release curve is complete are a challenging formulation to develop. Implants must be made from a small set of excipients, be tunable to release drug and allow for timed degradation. We will design and undertake preclinical development absorbable drug eluting implants of two drugs using scalable processing techniques. We will take our initial inspiration for the design of the implants from commercial testosterone subQ implants. The implants must also maintain mechanical strength over their usable life span and then dissolve. The core drug containing pellets will be designed so that they can be spray coated with a Wüster coater but still placed in a trocar for subQ insertion. By changing the thickness, crystallinity and other formulation variables of the rate controlling membrane we can modify the release of the drug and its duration. This particular implant system is designed to degrade in the period after the drug release has diminished. Our work will include long term release studies that generate many analytical samples, stability studies, development of methodology to study degradation and drug release. Furthermore, we will conduct pilot stability studies and assist with the technology transfer into CRO for clinical supply manufacturing. Development and optimization of innovative long-acting multipurpose technologies (MPTs) with contraceptive and HIV prevention activity We will complete the design engineering of a elvitegravir intrauterine system and develop manufacturing methods and test methods for the intrauterine system (IUS) being developed in this activity. We will reinforce and further engineer the wall/rate controlling membrane material and develop test methods to assure mechanical integrity of the IUS design. We will explore methods to include levonorgestril in the IUS reservoir or another reservoir design to achieve Mirena like release kinetics in vitro. We will support expanded product development, optimization, stress testing and tech transfer activities. We will also work to develop IUS systems that can elute other ARVs. Our work will include long term release studies that generate many analytical samples, stability studies, development of methodology to study degradation and drug release. Furthermore, we will conduct pilot stability studies and assist with the technology transfer into CRO for clinical supply manufacturing.\n|Effective start/end date\n|9/15/17 → 2/29/20\n- Eastern Virginia Medical School (NXS-17-001 AMD 1 // AID-OAA-A-17-00014)\n- Agency for International Development (NXS-17-001 AMD 1 // AID-OAA-A-17-00014)\nExplore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.", "domain": "chemistry", "round": 3} +{"url": "https://blog.cashins.com/blog-0/industrial-hygiene-working-safely-with-arsenic", "date": "2020-07-02T18:47:09Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-29/segments/1593655879738.16/warc/CC-MAIN-20200702174127-20200702204127-00018.warc.gz", "language_score": 0.9257745742797852, "token_count": 660, "dump": "CC-MAIN-2020-29", "global_id": "webtext-fineweb__CC-MAIN-2020-29__0__86142997", "lang": "en", "text": "Arsenic is a naturally-occurring metal that is found in the earth's crust. While its toxic properties have been known for centuries - it was the poison of choice for many ancient rulers who maneuvered to get in power or stay in power - arsenic's chemical properties make it an attractive raw ingredient in various industries including shipbuilding (blasting media and metal coatings may contain arsenic), construction (pressure-treated wood contains chromated copper arsenate), and semiconductor (gallium arsenide is used to manufacture diodes and other components). In addition, some arsenic-containing pesticides and herbicides are used today despite regulations that prohibit or restrict their use.\nArsenic injures and/or kills the cells in our bodies by one of several different physiological mechanisms. This explains why it is capable of damaging virtually every organ system. Arsenic can cause skin lesions, peripheral neuropathy, kidney and liver damage, and cardiac problems such as capillary leakage and cardiomyopathy. In addition, arsenic exposures are associated with increased numbers of miscarriages and birth defects. Finally, it is a confirmed human carcinogen that increases the risk of lung, skin, and bladder cancer.\nIt's important to point out that not all arsenic compounds have equal toxicity. Generally speaking, inorganic arsenic compounds are much more toxic than organic compounds. OSHA, in accordance with this disparity, regulates exposures to Inorganic Arsenic in the Standard 29 CFR 1910.1018.\nThe Standard begins by requiring employers to use engineering and work practice controls to maintain exposures below the Permissible Action Limit (PEL) of 10 micrograms per cubic meter (ug/m3). Respirators can supplement the engineering and work practice controls only if these other approaches do not reduce exposures below the PEL.\nThe Standard has other important requirements, including:\n- Establishing regulated areas when exposures exceed the PEL\n- Developing and implementing a written Compliance Plan\n- Complying with OSHA's Respiratory Protection Standard (if respirators are needed to control exposures below the PEL)\n- Providing protective work clothing and equipment\n- Complying with housekeeping requirements (including following specific cleaning methods)\n- Establishing hygiene facilities (change rooms, lunch rooms, etc.) and work practices\n- Instituting a medical surveillance program for employees exposed over OSHA's Action Level of 5 ug/m3 at least 30 days per year\n- Communicating arsenic's hazards by way of OSHA's Hazard Communication Program and posting signs in regulated areas\nAs you can see, the OSHA Standard has many specific requirements for companies that handle inorganic arsenic. While they may seem daunting, remember that they not only protect your workers, but they protect you and your company as well.\nDo you need help evaluating worker exposures to inorganic arsenic or other harmful agents in the workplace? Are you in full compliance with OSHA's Inorganic Arsenic Standard - and all the standards that apply to your company? Cashins can help you with all of your Industrial Hygiene and employee safety needs. Click on the \"Request an EH&S Assessment Online\" button at the right and we'll let you know how we can help you!", "domain": "chemistry", "round": 3} +{"url": "https://en.wikipedia.org/wiki/Granophyre", "date": "2019-11-22T08:47:05Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-47/segments/1573496671245.92/warc/CC-MAIN-20191122065327-20191122093327-00549.warc.gz", "language_score": 0.8507465720176697, "token_count": 549, "dump": "CC-MAIN-2019-47", "global_id": "webtext-fineweb__CC-MAIN-2019-47__0__88903963", "lang": "en", "text": "Granophyre (// GRAN-ə-fire; from granite and porphyry) is a subvolcanic rock that contains quartz and alkali feldspar in characteristic angular intergrowths such as those in the accompanying image.\nThe texture is called granophyric. The texture can be similar to micrographic texture and to the coarser graphic intergrowths of quartz and alkali feldspar common in pegmatite. These textures document simultaneous crystallization of quartz and feldspar from a silicate melt at the eutectic point, perhaps in the presence of a water-rich phase. They may also be formed by crystallization when the magma is significantly undercooled, not necessarily under eutectic conditions.\nGranophyres typically are intrusive rocks that crystallized at shallow depths, and many have compositions similar to those of granites. A common occurrence of granophyre is within layered igneous intrusions dominated by rocks with compositions like that of gabbro. In such occurrences, the granophyre may form as an end product of fractional crystallization of a parent mafic magma, or by melting of rocks into which the mafic magma was emplaced, or by a combination of the two processes.\nGranophyre may also form as the uppermost stratigraphic layer resulting from melting of upper-middle crustal rocks by a meteorite impact. For example, the upper layer of the Main Mass of the 1850 Ma Sudbury Structure is composed of fine-medium grained granitic rocks with abundant granophyric textures.\n- Micrographic texture\n- Rock microstructure – The texture of a rock and the small scale rock structures\n- Granite – A common type of intrusive, felsic, igneous rock with granular structure\n- \"Granophyre\". Oxford Dictionaries. Oxford University Press. Retrieved 2016-01-23.\n- \"Granophyre\". Merriam-Webster Dictionary. Retrieved 2016-01-23.\n- Lowenstern, J.B.; Clynne M.A.; Bullen T.D. (1997). \"Comagmatic A-Type Granophyre and Rhyolite from the Alid Volcanic Center, Eritrea, Northeast Africa\" (PDF). Journal of Petrology. Oxford University Press. 38 (12): 1707–1721. doi:10.1093/petroj/38.12.1707. Retrieved 7 July 2012.\n|This article related to petrology is a stub. You can help Wikipedia by expanding it.|", "domain": "chemistry", "round": 3} +{"url": "https://link.springer.com/article/10.1023/A:1014026831633", "date": "2019-01-18T03:35:13Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-04/segments/1547583659677.17/warc/CC-MAIN-20190118025529-20190118051529-00002.warc.gz", "language_score": 0.7458664178848267, "token_count": 906, "dump": "CC-MAIN-2019-04", "global_id": "webtext-fineweb__CC-MAIN-2019-04__0__132848522", "lang": "en", "text": "A Comparative Characterization of Kaolins of Provenance from the Prosyanovskoe and Kyshtymskoe Deposits Subjected to Mechanochemical Activation in an Aqueous Medium\n- 19 Downloads\nThe effect of mechanical activation in an aqueous medium on properties of kaolins of provenance from the Prosyanovskoe and Kyshtymskoe deposits — typical representatives of high-grade and low-grade kaolins — is studied. The activation in an aqueous medium produces a substantial effect on the crystallinity of kaolins and the process of phase formation in heat-treated kaolins. The mechanochemical activation, backed up by an accumulated and systematized experimental data, can provide a simple and readily available way toward improving the quality of kaolins.\nKeywordsPolymer Experimental Data Aqueous Medium Mechanical Activation Phase Formation\nUnable to display preview. Download preview PDF.\n- 1.V. Ya. Shevchenko and G. N. Maslennikova, “Problems in the supply of raw materials for the ceramic industry of Russia,” Neorg. Mater., 31(2), 286-288 (1995).Google Scholar\n- 2.G. N. Maslennikova, “Trends in the development of aluminosilicate ceramic,” Steklo Keram., No. 2, 10-14 (2001).Google Scholar\n- 3.N. F. Solodskii, M. I. Solodskaya, and A. S. Shashrikov, “A qualitative characterization of the technological properties of kaolins of provenance from deposits in republics of the former Soviet Union,” Ogneup. Tekh. Keram., No. 10. 34-37 (2000).Google Scholar\n- 4.N. F. Solodskii, M. I. Solodskaya, and A. S. Shashrikov, “The use of kaolin of provenance from the Zhuravlinyi Log deposit for production of fine ceramics,” Steklo Keram., No. 5, 34-37 (2000).Google Scholar\n- 5.B. S. Skidan, N. A. Moslenko, Z. F. Zemlyakova, and V. B. Ermakova, “The use of kaolin of provenance from the Zhuravlinyi Log deposit for production of high-voltage insulators,” Steklo Keram., No. 6, 20-21 (1999).Google Scholar\n- 6.S. S. Ordan'yan, K. P. Andreev, and E. K. Stepanenko, “Vibratory grinding and the effect of mechanical activation on the sintering and properties of a mullite-based ceramic,” Zh. Prikl. Khim., No. 12, 1978-1982 (1998).Google Scholar\n- 7.G. D. Semchenko, I. N. Opryshko, and Ya. N. Goncharenko, “A mechanochemical synthesis of mullite,” Steklo Keram., No. 12, 23-24 (1999).Google Scholar\n- 8.T. F. Grigor'eva, I. A. Vorsina, I. P. Barinova, and N. Z. Lyakhov, “The incipient process of mechanical activation of kaolinite and talcum,” Neorg. Mater., 32(1), 84-88 (1996).Google Scholar\n- 9.A. I. Avgustinik, Ceramics [in Russian], Stroiizdat, Leningrad (1975).Google Scholar\n- 10.I. I. Plyusnina, Infrared Spectra of Minerals [in Russian], Moscow State University (MGU), Moscow (1976).Google Scholar\n- 11.I. A. Gribina, Yu. I. Tarasevich, and I. I. Plyusnina, “Spectroscopic evidence of disorder in the structure of kaolin,” Vestn. Mosk. Univ., No. 6, 23-26 (1972).Google Scholar", "domain": "chemistry", "round": 3} +{"url": "https://experts.nebraska.edu/en/publications/effect-of-dissolved-organic-carbon-on-the-transport-and-attachmen", "date": "2022-09-27T05:04:29Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-40/segments/1664030334987.39/warc/CC-MAIN-20220927033539-20220927063539-00370.warc.gz", "language_score": 0.9423856735229492, "token_count": 472, "dump": "CC-MAIN-2022-40", "global_id": "webtext-fineweb__CC-MAIN-2022-40__0__230574341", "lang": "en", "text": "Transport of Cryptosporidium parvum oocysts and microspheres in two disparate (a clay- and Fe-rich, volcanic and a temperate, humic) agricultural soils were studied in the presence and absence of 100 mg L -1 of sodium dodecyl benzene sulfonate (SDBS), and Suwannee River Humic Acid (SRHA) at pH 5.0-6.0. Transport of carboxylate-modified, 1.8 μm microspheres in soil columns was highly sensitive to the nature of the dissolved organic carbon (DOC), whereas oocysts transport was more affected by soil mineralogy. SDBS increased transport of microspheres from 48% to 87% through the tropical soil and from 43% to 93% in temperate soil. In contrast, SRHA reduced transport of microspheres from 48% to 28% in tropical soil and from 43% to 16% in temperate soil. SDBS also increased oocysts transport through the temperate soil 5-fold, whereas no oocyst transport was detected in tropical soil. SRHA had only a nominal effect in increasing oocysts transport in tropical soil, but caused a 6-fold increase in transport through the temperate soil. Amendments of only 4 mg L -1 SRHA and SDBS decreased oocyst hydrophobicity from 66% to 20% and from 66% to 5%, respectively. However, SDBS increased microsphere hydrophobicity from 16% to 33%. Soil fines, which includes clays, and SRHA, both caused the oocysts zeta potential (?) to become more negative, but caused the highly hydrophilic microspheres to become less negatively charged. The disparate behaviors of the two colloids in the presence of an ionic surfactant and natural organic matter suggest that microspheres may not be suitable surrogates for oocysts in certain types of soils. These results indicate that whether or not DOC inhibits or promotes transport of oocysts and microspheres in agricultural soils and by how much, depends not only on the surface characteristics of the colloid, but the nature of the DOC and the soil mineralogy.\nASJC Scopus subject areas\n- Environmental Chemistry", "domain": "chemistry", "round": 3} +{"url": "https://www.cat.com/en_US/articles/solutions/marine/marine-engine-maintenancetips.html.html", "date": "2019-09-18T22:53:43Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-39/segments/1568514573368.43/warc/CC-MAIN-20190918213931-20190918235931-00557.warc.gz", "language_score": 0.9286582469940186, "token_count": 420, "dump": "CC-MAIN-2019-39", "global_id": "webtext-fineweb__CC-MAIN-2019-39__0__45283688", "lang": "en", "text": "To keep your vessel moving on the water, start by maintaining your engine. Basic maintenance on your engine can reduce downtime and minimize overall owning and operating costs. Below are a few do-it-yourself tips to routinely perform before you head out for the waves.\n#1: Use Antifreeze\nAntifreeze is used to protect the engine coolant from freezing. In areas of the world where the temperature drops below 32 degrees F (0 degrees C), at least a 50 percent glycol concentration (antifreeze) is needed to avoid cracked blocks. Antifreeze also raises the boiling point of water. As such, a minimum of 30 percent glycol concentration is recommended in warm climates for protection against engine overheating\n#2: Check & Clean Your Battery\nBatteries are required to do more and more on modern boats, including starting engines and powering radios, radar, lights, pumps and other electronics. Batteries have a finite life, which depends in part on the quality built in by the manufacturer. Regardless of the type of battery in your boat, there are some basic steps you can take to keep it working properly:\n#3: Use Proper Engine Fluids\nThe first step for critical cooling system care is making sure you’re using the proper fluids. Either distilled or deionized water should be used with approved antifreeze and approved supplemental coolant additive or rust inhibitor. (Fishermen in warmer climates don’t need to use antifreeze, but must still use the coolant conditioners.) Use a low-silicate antifreeze that meets one of the following specifications: GM 6038-M or ASTM #D4985. The fluid in the jacket water cooling system should not consist of plain tap water or water which has been “softened” by a domestic water softener. Tap water is not recommended for engine cooling systems because of additives, contaminants and other chemicals (such as salt, chlorides, sulfates, etc.) found in the water.", "domain": "chemistry", "round": 3} +{"url": "https://jpier.org/PIERM/pier.php?paper=13011604", "date": "2022-07-05T04:00:01Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-27/segments/1656104512702.80/warc/CC-MAIN-20220705022909-20220705052909-00363.warc.gz", "language_score": 0.7149085998535156, "token_count": 2342, "dump": "CC-MAIN-2022-27", "global_id": "webtext-fineweb__CC-MAIN-2022-27__0__137374177", "lang": "en", "text": "Present work deals with the microwave absorption characteristics of BaFe12O19 of interest as radar absorbing material (RAM). There are very few reported works available where particle size has been critically analyzed for absorbing characteristics at microwave frequencies, therefore, in this paper microwave absorption properties of the BaFe12O19 with different particle sizes were investigated. The results showed that the particle size had significant influence on the dielectric and absorption properties of the composites in the 8.2-12.4 GHz frequency range. BaFe12O19 powder of different particle sizes were synthesized by varying the annealing time and it was observed that the real part of permittivity of the composite increases from 5.18 (average value) to 7.50 (average value) and imaginary part increases from an average value of 0.20 to an average value of 2.33, whereas the real part of permeability increases from 0.95 (average value) to 1.11 (average value) and imaginary part of permeability was measured in the range of 0.02 to 0.07. These changes in permittivity and permeability affects microwave absorption application. It is observed that the maximum bandwidth for average particle size of 240 nm is 3.02 GHz and with the increase in average particle size, microwave absorption properties increased.\n2. Singh, P., V. K. Babbar, A. Razdan, S. L. Srivastava, V. K. Agrawal, and T. C. Goel, \"Dielectric constant, magnetic permeability and microwave absorption studies of hot-pressed Ba-CoTi hexaferrite composites in X-band,\" Journal of Material Science, Vol. 41, 7190-7196, 2006.\n3. Mu, G., N. Chen, X. Pan, H. Shen, and M. Gu, \"Preparation and microwave absorption properties of Barium ferrite nanorods,\" Materials Letters, Vol. 62, 840-842, 2008.\n4. Ohlan, A. , K. Singh, N. Gandhi, A. Chandra, S. K. Dhawan, and , \"Microwave absorption properties of NiCoFe2O4-graphite embed- ded poly (o-phenetidine) nanocomposites,\" AIP Advances, Vol. 1, 032157, 2011.\n5. Ozgiir, U., Y. Alivov, and H. Morkoc, \"Microwave ferrites, Part 1: Fundamental properties,\" Journal of Material Science: Materials Electronics, Vol. 20, 789-834, 2009.\n6. Hlavacek, V. and J. A. Puszynski, \"Chemical engineering aspects of advanced ceramic materials,\" Industrial & Engineering Chemistry Research,, Vol. 35, 349-377, 1996.\n7. Liu, M., X. Shen, F. Song, J. Xiang, and R. Liu, \"Effect of heat treatment on particle growth and magnetic properties of electrospun Sr0.8La0.2Zn0.2Fe11.8O19 nano fibers,\" Journal of SolGel Science and Technology, Vol. 59, 553-560, 2011.\n8. Bezerra, , C. W. B., L. Zhang, H. Liu, K. Lee, A. L. B. Marques, E. P. Marques, H. Wang, and J. Zhang, \"A review of heat-treatment effects on activity and stability of PEM fuel cell catalysts for oxygen reduction reaction,\" Journal of Power Sources, Vol. 173, 891-908, 2007.\n9. Meshram, M., N. K. Agrawal, B. Sinha, and P. S. Misra, \"Characterization of (Co-Mn-Ti) substituted M-type Barium hexagonal ferrite based microwave absorber at X-band,\" IEEE Proceedings of 6th International Symposium on Antennas, Propagation and EM Theory,, 746-749, 2003.\n10. Tang, X., Y. Yang, and K. Hu, \"Structure and electromagnetic behavior of BaFe12-2x(Ni0.8Ti0.7)xO19-0.8x in the 2-12 GHz frequency range,\" Journal of Alloys and Compounds, Vol. 477, 488-492, 2009.\n11. Kumar, A., V. Agarwala, and D. Singh, \"Effect of Mg-substitution on microwave absorption of BaFe12O19,\" Advanced Materials Research, Vol. 585, 62-66, 2012.\n12. Qiua, , J., M. Gu, and H. Shen, \"Microwave absorption properties of Al- and Cr-substituted M-type barium hexaferrite,\" Journal of Magnetism and Magnetic Materials, Vol. 295, 263-268, 2005.\n13. Qiu, J., Y. Wang, and M. Gu, \"Effect of Cr substitution on microwave absorption of BaFe12O19,\" Materials Letter, Vol. 60, 2728-2732, 2006.\n14. Panda, R. N., J. C. Shih, and T. S. Chin, \"Magnetic properties of nano-crystalline Gd- or Pr-substituted CoFe2O4 synthesized by the citrate precursor technique,\" Journal of Magnetism and Magnetic Material, Vol. 257, 79-86, 2003.\n15. Tyagi, S., H. B. Baskey, R. C. Agarwala, V. Agarwala, and T. C. Shami, \"Development of hard/soft ferrite nanocomposite for enhanced microwave absorption,\" Ceramics International, Vol. 37, 2631-2641, 2011.\n16. Tyagi, S., H. B. Baskey, R. C. Agarwala, V. Agarwala, and T. C. Shami, \"Reaction kinetic, magnetic and microwave absorption studies of SrFe12O19/CoFe2O4 ferrite nanocrystals,\" Transactions of the Indian Institute of Metals, Vol. 64, 271-277, 2011.\n17. Zhang, H., M. Wu, X. Yao, and L. Zhang, \"Complex permittivity, permeability, and microwave absorption of Barium ferrite by citrate sol-gel process,\" Rare Metals, Vol. 22, 125-130, 2003.\n18. Holland, T. J. B. and S. A. T. Redfern, \"Unit cell refinement from powder di®raction data: The use of regression diagnostics,\" Mineralogical Magazine, Vol. 61, 65-67, 1997.\n19. Meza, V. A., X. Gratens, and R. F. Jardim, \"Preparation and general physical properties of polycrystalline PrBa2Cu3O77-y obtained from sol-gel precursors,\" Brazilian Journal of Physics, Vol. 32, 731-738, 2002.\n20. Sharma, R., R. C. Agarwala, and V. Agarwala, \"Development of radar absorbing nano crystals by microwave irradiation,\" Materials Letters, Vol. 62, 2233-2236, 2008.\n21. Taylor, P., \"Ostwald ripening in emulsions,\" Advances in Colloid and Interface Science, Vol. 75, 107-163, 1998.\n22. Bahadoor, A., Y. Wang, and M. N. Afsar, \"Complex permittivity and permeability of barium and strontium ferrite powders in X, Ku, and K-band frequency ranges ,\" Journal of Applied Physics, Vol. 97, 10F105-1-10F105-3, 2005.\n23. Giannakopoulou, T., L. Kompotiatis, A. Kontogeorgakos, and G. Kordas, \"Microwave behavior of ferrites prepared via sol-gel method,\" Journal of Magnetism and Magnetic Materials, Vol. 246, 360-365, 2002.\n24. Zhang, H., Z. Liu, C. Ma, Y. Xi, L. Zhang, and M. Wu, \"Complex permittivity, permeability, and microwave absorption of Zn- and Ti-substituted barium ferrite by citrate sol-gel process,\" Materials Science and Engineering B, Vol. 96, 289-295, 2002.\n25. Zou, H., S. Li, L. Zhang, S. Yan, H. Wu, S. Zhang, and M. Tian, \"Determining factors for high performance silicone rubber microwave absorbing materials,\" Journal of Magnetism and Magnetic Materials, Vol. 323, 1643-1651, 2011.\n26. Zhou, Z., L. Chu, and S. Hu, \"Microwave absorption behaviors of tetra-needle-like ZnO whiskers,\" Materials Science and Engineering B, Vol. 126, 93-96, 2006.", "domain": "chemistry", "round": 3} +{"url": "https://www.ojs.diffundit.com/index.php/sema/article/view/1464", "date": "2024-03-05T13:02:23Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707948235171.95/warc/CC-MAIN-20240305124045-20240305154045-00400.warc.gz", "language_score": 0.8893956542015076, "token_count": 511, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__135564470", "lang": "en", "text": "Mycotoxins, including Aflatoxin B1 (AFB1), pose major medical problems since they can contaminate human and pet food. Mycotoxin incorporation is linked to acute and chronic toxicity by causing acute liver damage and inflammation, while chronic exposure is linked to liver carcinogenesis. Although it is well established that AFB1 causes bulky, mutagenic DNA base adducts, the detailed mechanisms and DNA damage signalling events underlying acute AFB1 cytotoxicity are still incompletely defined. The DNA damage-activated kinase HIPK2 is a central regulator of cell death in response to genotoxic stress. The role of HIPK2 in mycotoxin toxicity remains currently unknown.\nHere we analysed the molecular events and DNA signalling pathways underlying acute mycotoxin genotoxicity. Our results revealed a critical role for HIPK2 in AFB1-mediated genotoxicity. Acute exposure of human liver cells to AFB1 results in site-specific HIPK2 autophosphorylation and activation. In consequence, active HIPK2 phosphorylates p53 at Ser46 and triggers cell death through both ferroptosis and apoptosis induction. Pharmacological HIPK2 inhibition inhibits p53 Ser46 phosphorylation. Furthermore, we found that AFB1 exposure triggers DNA replication stress involving checkpoint kinase ATR activation, RPA phosphorylation and stalling of replication forks, reflected by DNA fibre assays. In addition, by making use of select kinase inhibitors we demonstrate that AFB1-induced HIPK2 activation is mediated by checkpoint kinases ATR thereby linking HIPK2 activation to DNA replication stress. Confocal microscopy revealed that upon AFB1 exposure active HIPK2 accumulates at DNA breaks in an ATR-dependent manner, suggesting HIPK2 activation takes place at DNA breaks. Pharmacological inhibition of ATR and the down-stream activated checkpoint kinase ATM inhibits AFB1 cytotoxicity in liver cells, suggesting DNA damage checkpoint kinase inhibition as potential intervention option to mitigate acute AFB1 hepatotoxicity. Collectively, our results reveal DNA replication stress as a critical mechanism of AFB1 hepatotoxicity through triggering a detrimental ATR-HIPK2-p53 signalling axis. Finally, our data suggest select DNA damage checkpoint kinase inhibitors as potential antidots to treat acute mycotoxin toxicity.\nThis work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.\nCopyright (c) 2023 Spanish Journal of Environmental Mutagenesis and Genomics", "domain": "chemistry", "round": 3} +{"url": "https://www.bio-conferences.org/articles/bioconf/abs/2017/02/bioconf-oiv2017_04009/bioconf-oiv2017_04009.html", "date": "2021-09-22T18:42:28Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-39/segments/1631780057371.69/warc/CC-MAIN-20210922163121-20210922193121-00404.warc.gz", "language_score": 0.9098484516143799, "token_count": 467, "dump": "CC-MAIN-2021-39", "global_id": "webtext-fineweb__CC-MAIN-2021-39__0__98315209", "lang": "en", "text": "BIO Web Conf.\nVolume 9, 201740th World Congress of Vine and Wine\n|Number of page(s)||4|\n|Section||Wine and Society|\n|Published online||04 July 2017|\nPotential of lactic acid bacteria as suppressors of wine allergies\nEge University, Department of Food Engineering, 35100\nBornova, Izmir, Turkey\nAllergens causes some symptoms as all asthma, allergic conjunctivitis, and allergic rhinitis. These symptoms are seen twice as many in women than in men. The major wine allergens reported in wines are endochitinase 4A and lipid-transfer protein (LTP). This review deal with possibilities of using lactic acid bacteria as suppressors of wine allergies. Phenolic compounds present in wines have not only antioxidant properties causing radical scavenging but also some special properties reported in many in vitro studies as regulating functions in inflammatory cells as mast cells. So what is the role of lactic acid bacteria in these cases? Lactic acid bacteria are used during malolactic fermentation step of wine production with purpose of malic acid reduction. During this bioconversion complex phenolic compounds could be hydrolysed by bacterial enzymes to their aglycone forms. Obtained aglycons could pass through the intestinal epithelium of human and allowed reduction of IgE antibody production by affecting Th1/ Th2 ratio. Considering different contents and quantities of phenols in different grape varieties and consequently in different wines more studies are required in order to determine which lactic acid bacteria and strains could be effective in suppressing wine allergens.\n© The Authors, published by EDP Sciences 2017\nThis is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0 (http://creativecommons.org/licenses/by/4.0/).\nCurrent usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.\nData correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.\nInitial download of the metrics may take a while.", "domain": "chemistry", "round": 3} +{"url": "http://www.canterbury.ac.nz/courseinfo/GetCourseDetails.aspx?course=CHEM111&occurrence=18S2(C)&year=2018", "date": "2018-06-18T01:33:42Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-26/segments/1529267859923.59/warc/CC-MAIN-20180618012148-20180618032148-00259.warc.gz", "language_score": 0.82823646068573, "token_count": 300, "dump": "CC-MAIN-2018-26", "global_id": "webtext-fineweb__CC-MAIN-2018-26__0__99223695", "lang": "en", "text": "Use the Tab and Up, Down arrow keys to select menu items.\nAtoms and the periodic table; chemical bonding; reduction and oxidation reactions; properties of gases; introduction to thermodynamics; kinetics; chemical equilibrium; Gibbs energy and the second law of thermodynamics; aqueous chemistry; acid-base equilibrium.\nThis course will provide students with an opportunity to develop the Graduate Attributes specified below:\nCritically competent in a core academic discipline of their award\nStudents know and can critically evaluate and, where applicable, apply this knowledge to topics/issues within their majoring subject.\n(1) NCEA: at least 14 credits NCEA Level 3 Chemistry, or (2) CIE: at least D grade in CIE AL Chemistry or A grade in CIE ASL Chemistry, or (3) IB: at least Grade 4 in IB HL Chemistry or Grade 6 in IB SL Chemistry, or (4) CHEM114, or at least B Grade in BRDG023.\nStudents must attend one activity from each section.\n, Greg Russell\n, Paul Kruger\nand Owen Curnow\nCourse handout and content (PDF 266KB)\nDomestic fee $865.00\nInternational fee $3,788.00\n* Fees include New Zealand GST and do not include any programme level discount or additional course related expenses.\nFor further information see\nSchool of Physical & Chemical Sciences on the department and colleges page.", "domain": "chemistry", "round": 3} +{"url": "https://pocketdentistry.com/evaluation-of-current-zirconia-primers-for-zirconia-bonding/", "date": "2021-04-16T11:39:24Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-17/segments/1618038056325.1/warc/CC-MAIN-20210416100222-20210416130222-00048.warc.gz", "language_score": 0.8251436352729797, "token_count": 496, "dump": "CC-MAIN-2021-17", "global_id": "webtext-fineweb__CC-MAIN-2021-17__0__115408332", "lang": "en", "text": "Objectives : Traditional HF etching and silane treatment is not effective for improving the bonding towards zirconia ceramics. The purpose of this study was to evaluate the bonding ability of current zirconia bonding agents.\nMaterials and methods : Zirconia (Cercon) disks were sandblasted by alumina (50 μm), then cleaned by de-ionized water and dried. According to manufacturers’ instructions, zirconia surface was applied commercial primers and proceeded cementations using ultradent jig methods, i.e. Z PRIME+ /Duolink (Bisco), Clearfil Ceramic Primer/Panavia F2.0 (Kuraray), AZ Primer/ResiCem (Shofu), Metal/Zirconia Primer/Multilink Automix (Ivoclar Vivadent), and Monobond Plus/Multilink Automix (Ivoclar Vivadent). Cements were either light cured for 40 s or self-cured for 10 min at 37 °C. The cured specimens were then stored for 2 h at 37 °C in de-ionized water and tested until failure using a universal tester (Instron 4466) at a speed of 1 mm/min.\n|Zirconia bonding primer||SBS in MPa (SD) cement self-cured||SBS in MPa (SD) cement light-cured|\n|Z PRIME+ (Bisco)||23.0 (5.3) a, A||28.7 (5.7) a, A|\n|Clearfil Ceramic Primer (Kuraray)||8.9 (4.0) b, A||7.5 (4.5) c, A|\n|AZ Primer (Shofu)||12.5 (5.9) b, A||21.2 (8.3) ab, B|\n|Metal/Zirconia Primer (Ivoclar Vivadent)||8.2 (2.0) b, A||16.3 (5.0) b, B|\n|Monobond Plus (Ivoclar ivadent)||10.8 (3.3) b, A||26.4 (8.8) a, B|", "domain": "chemistry", "round": 3} +{"url": "http://www.npc-rt.ir/reserachmanager-nonpolymeric-en.html", "date": "2013-05-25T06:40:53Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2013-20/segments/1368705575935/warc/CC-MAIN-20130516115935-00061-ip-10-60-113-184.ec2.internal.warc.gz", "language_score": 0.9129122495651245, "token_count": 417, "dump": "CC-MAIN-2013-20", "global_id": "webtext-fineweb__CC-MAIN-2013-20__0__15279516", "lang": "en", "text": "Chemical (Non-polymer) Research Group\nPossessing the skilled industrial and academic manpower as well as technical facilities, i.e. bench scale and pilot plants, Chemical Research Group has concentrated on developing NPC’s policies and strategic plans.\nFurthermore, to utilize the scientific potential inside Iran, it has already organized several research teams that are comprised of experienced engineers from petrochemical complexes, university consultants, and researchers.\nThe main responsibility of research team is to define and supervise purposeful projects in accordance with NPC-RT’s programs continuously\nChemical Research Group implements joint research projects in collaboration with international licensors and well-known of pilot plants.\nOne of the most important missions of this group is to manage research project on chemical processes and products in line with NPC’s strategic plan through comprehensive study of plant, recognition, optimization, and finally developing the process.\nv Developing process know-how of existing and new plants through design, construction, and commissioning of pilot plants\nv Improving the efficiency of existing plants\nv Optimizing the energy consumption\nv Changing process wastes into value-added products\nTo meet the mentioned objectives, NPC-RT employs top graduates of universities of high rank through scientific interviews. They are trained in compliance with research project requirements using different types of training courses held inside and outside Iran. In order to achieve Basic Design and Engineering calculation experience, special training courses are organized employing famous companies. Moreover, process simulator software is produced to analyze the plants precisely.\nDeveloping the know-how of the following processes are the most important priorities of Chemical Research Group.\nv Methanol to Propylene (MTP)\nv Dimethyl Ether\nv Propane Dehydrogenation\nv Methyle Acetate Hydrolysis\nv Synthesis Gas\nv Recovery and re-construction of membrane out of used ones in Chloro Alkali (C.A.) Plant Furnace\nv Structured Packing Column\nv Homogeneous Catalysts in acetic acid process", "domain": "chemistry", "round": 3} +{"url": "http://leeassocreporters.com/news-articles-on-carbon-dating.php", "date": "2020-04-03T10:14:40Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-16/segments/1585370510846.12/warc/CC-MAIN-20200403092656-20200403122656-00049.warc.gz", "language_score": 0.9600487351417542, "token_count": 381, "dump": "CC-MAIN-2020-16", "global_id": "webtext-fineweb__CC-MAIN-2020-16__0__141363794", "lang": "en", "text": "News articles on carbon dating. The institute for creation research\nThere should be no measurable carbon 14 after about 40, — 50, years. The article was first published on October 18, The textbooks say that coal formed million years ago.\nSo I sent Dean a request for permission to include his painting here on our website and he graciously agreed to share it with us. Here are some things to consider about carbon dating.\nCarbon dating is used to work out the age of organic material — in effect, any living thing. If the fossil only contains half as much carbon 14 as the atmosphere, it is assumed to have been dead for one half-life, or 5, years.\nAs we mentioned above, the carbon to carbon ratio in the atmosphere remains nearly constant. In theory the amount of carbon 14 never goes to zero.\nGet smart. Sign up for our email newsletter.\nVarious geologic, atmospheric and solar processes can influence atmospheric carbon levels. So what they do is compare the amount of carbon 14 in the fossil to the amount of carbon 14 in the atmosphere.\nMy dear friend Fr. They wanted to figure out how long it would take the atmosphere to reach a point where the construction rate and the destruction rate of carbon 14 was the same.\nThe atmosphere has very distinctive layers to it.\nThis has changed over the past few decades because of the dramatic advances in digital imaging technologies and computer power. However, this is the logic most scientists have. I make my second presentation on Thursday, February 22nd at 7: It can be used on objects as old as about 62, years.\nThe technique hinges on carbon, a radioactive isotope of the element that, unlike other more stable forms of carbon, decays away at a steady rate.\nThis is only because the geologic column has been taught for so long now and is assumed to be true.", "domain": "chemistry", "round": 3} +{"url": "https://www.dictionary.com/browse/desalinization", "date": "2019-04-22T01:10:20Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-18/segments/1555578532948.2/warc/CC-MAIN-20190421235818-20190422020958-00008.warc.gz", "language_score": 0.7487354874610901, "token_count": 287, "dump": "CC-MAIN-2019-18", "global_id": "webtext-fineweb__CC-MAIN-2019-18__0__164084460", "lang": "en", "text": "[dee-sal-uh-nahyz, -sey-luh-, -lahy-]\nverb (used with object), de·sal·in·ized, de·sal·in·iz·ing.\n- desaix de veygoux,\n- desaix de veygoux, louis charles antoine,\n- desargues's theorem\nAlso especially British, de·sal·in·ise.\nOrigin of desalinize\nDictionary.com Unabridged Based on the Random House Unabridged Dictionary, © Random House, Inc. 2019\nThe removal of salt or other chemicals from something, such as seawater or soil. Desalinization can be achieved by means of evaporation, freezing, reverse osmosis, ion exchange, and electrodialysis.\nThe American Heritage® Science Dictionary Copyright © 2011. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.\nAny process that removes salt from water.\nThe term is usually applied to processes that remove salt from seawater to make it available for human consumption and agriculture. Such processes tend to be very expensive.\nThe New Dictionary of Cultural Literacy, Third Edition Copyright © 2005 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.cn/products/proteins-peptides/mtbp-peptide-ab6235.html", "date": "2023-06-04T12:53:40Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-23/segments/1685224649986.95/warc/CC-MAIN-20230604125132-20230604155132-00004.warc.gz", "language_score": 0.7423239946365356, "token_count": 541, "dump": "CC-MAIN-2023-23", "global_id": "webtext-fineweb__CC-MAIN-2023-23__0__245086451", "lang": "en", "text": "Key features and details\n- Suitable for: Blocking\nOur Abpromise guarantee covers the use of ab6235 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\nConcentration information loading...\nShipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. The product can be stored for up to 12 months.\nPreservative: 0.02% Sodium azide\nConstituents: 0.1% BSA, PBS\n- MDM 2 binding protein\n- MDM 2 BP\n功能Inhibits cell migration in vitro and suppresses the invasive behavior of tumor cells (By similarity). May play a role in MDM2-dependent p53/TP53 homeostasis in unstressed cells. Inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability. This promotes MDM2-mediated ubiquitination of p53/TP53 and its subsequent degradation.\n序列相似性Belongs to the MTBP family.\n- Information by UniProt\nTo our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.", "domain": "chemistry", "round": 3} +{"url": "https://www.e3s-conferences.org/articles/e3sconf/abs/2019/24/e3sconf_wri-162018_11004/e3sconf_wri-162018_11004.html", "date": "2019-12-11T01:55:33Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-51/segments/1575540529516.84/warc/CC-MAIN-20191210233444-20191211021444-00322.warc.gz", "language_score": 0.8781024813652039, "token_count": 624, "dump": "CC-MAIN-2019-51", "global_id": "webtext-fineweb__CC-MAIN-2019-51__0__103679181", "lang": "en", "text": "E3S Web Conf.\nVolume 98, 201916th International Symposium on Water-Rock Interaction (WRI-16) and 13th International Symposium on Applied Isotope Geochemistry (1st IAGC International Conference)\n|Number of page(s)||5|\n|Section||Advances in Analytical Techniques for the Study of Water-Rock Interaction|\n|Published online||07 June 2019|\nMicroscale effects of oxygen and light on bacterial sulfate reduction in organic-rich lacustrine sediments\nBiotechnology and Natural Resources Section, Institute for Regional Development (IDR), University of Castilla-La Mancha (UCLM), Campus Universitario s/n, 02071 Albacete, Spain\n* Corresponding author: JuanJose.Gomez@uclm.es\nBiogeochemical cycling involves the exchange of electrons between chemical species through redox reactions. Microorganisms can utilize energy released by redox reactions for their metabolism following a thermodynamic sequence. Among these reactions, the dissimilatory reduction of sulfate (SO42−) to produce hydrogen sulfide (H2S) is one of the most important microbially-mediated pathways. The use of microelectrodes at the water-sediment interface provided a better understanding of sulfate reduction processes in the suboxic and anoxic zones. The goal of this study was to assess the microzonation of H2S and O2 under different conditions of light and oxygen in the water column. For this purpose, organic-rich lacustrine sediments from Pétrola Lake (SE Spain) were used. Sediment incubations were performed in mesocosm devices. The highest production of H2S (up to 0.36 nmol/cm-3s-1) was observed under anoxic and dark conditions. Production under those conditions was several orders of magnitude higher than those measured when oxygen was present in the water column. Furthermore, the absence of O2 in the water column significantly altered the microzonation of H2S in depth. The absence of light seems not to affect the dynamics of O2 and H2S in depth. The study contributes to our understanding of microzonation in organic-rich sediments.\n© The Authors, published by EDP Sciences, 2019\nThis is an open access article distributed under the terms of the Creative Commons Attribution License 4.0 (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.\nCurrent usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.\nData correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.\nInitial download of the metrics may take a while.", "domain": "chemistry", "round": 3} +{"url": "http://compressors.processengineer.info/dry-gas-seals-seal-gas-supply-and-venting-systems.html", "date": "2022-01-22T19:02:34Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-05/segments/1642320303868.98/warc/CC-MAIN-20220122164421-20220122194421-00258.warc.gz", "language_score": 0.8882676959037781, "token_count": 350, "dump": "CC-MAIN-2022-05", "global_id": "webtext-fineweb__CC-MAIN-2022-05__0__70573956", "lang": "en", "text": "Depending on the service and seal arrangement, seal gas can either be supplied from the compressor gas stream or from an external source. As previously described, double seals will inherently require externally supplied inert seal gas. Tandem seals or single seals can use either compressor discharge gas or an external supply of gas. Examples of the latter include nitrogen, hydrogen, fuel gas and other by-product gases. Determining factors include the availability and cost of a suitable and reliable external gas supply and the characteristics of the gas from each source (cleanliness, liquid/moisture content, toxicity, thermodynamic properties, etc.).\nNote In order for dry gas seals to operate reliably, it is essential that a constant and sufficient supply of seal gas be delivered in a clean and dry condition. Although this appears straightforward, gas seal failures are often a result of not meeting this requirement.\nSome of the unanticipated conditions that may be encountered include:\n• Loss of externally supplied seal gas\n• Insufficient seal gas while compressor is at idle speed or stopped\n• Excessive supply system pressure drop in low pressure (close to 1 atmosphere) services\n• Reverse pressurization if suction pressure and seal gas fall below vent pressure (possible during startup in low pressure services)\n• Reverse pressurization if vent pressure rises above seal gas pressure (possible during flare system excursions in low pressure services)\n• Reverse pressurization on loss of seal gas supplied to double seals\n• Saturated seal gas due to changes in the process\n• Liquid formation in the seal gas due pressure letdown cooling\n• Oil mist contamination from external seal gas source compression system\n• Filter element failures due to pressure pulsations from an external seal gas source supply system", "domain": "chemistry", "round": 3} +{"url": "http://www.abcam.com/PBK-antibody-EP2520Y-ab75987.html", "date": "2013-12-11T08:23:06Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2013-48/segments/1386164033639/warc/CC-MAIN-20131204133353-00011-ip-10-33-133-15.ec2.internal.warc.gz", "language_score": 0.7945836186408997, "token_count": 1122, "dump": "CC-MAIN-2013-48", "global_id": "webtext-fineweb__CC-MAIN-2013-48__0__42726161", "lang": "en", "text": "Anti-PBK antibody [EP2520Y] (ab75987)\n- Product nameAnti-PBK antibody [EP2520Y]See all PBK primary antibodies ...\n- DescriptionRabbit monoclonal [EP2520Y] to PBK\n- Tested applicationsWB, IP, ICC, Flow Cyt, IHC-P more details\n- Species reactivityReacts with: Human\nDoes not react withMouse, Rat\nSynthetic peptide corresponding to residues from the C-terminus of human PBK\n- Positive control\n- Human tonsil. HeLa cell lysate.\n- General notesProduced under U.S. Patent No. 5,675,063.\n- Storage instructionsStore at -20°C. Stable for 12 months at -20°C\n- Storage bufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%\n- PurityTissue culture supernatant\n- Clonality Monoclonal\n- Clone numberEP2520Y\nOur Abpromise guarantee covers the use of ab75987 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\n|WB||WB: 1/100000 - 1/500000. Detects a band of approximately 36 kDa (predicted molecular weight: 36 kDa).|\n|ICC||ICC: 1/100 - 1/250.|\n|Flow Cyt||Flow Cyt: 1/1000.|\n|IHC-P||IHC-P: 1/100 - 1/250.\nAntigen retrieval is recommended.\n- FunctionPhosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage.\n- Tissue specificityExpressed in the testis and placenta. In the testis, restrictedly expressed in outer cell layer of seminiferous tubules.\n- Sequence similaritiesBelongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase kinase subfamily.\nContains 1 protein kinase domain.\nmodificationsPhosphorylated; in a cell-cycle dependent manner at mitosis.\n- Cancer/testis antigen 84 antibody\n- CT84 antibody\n- FLJ14385 antibody\n- Lymphokine activated killer T cell originated protein kinase antibody\n- Lymphokine-activated killer T-cell-originated protein kinase antibody\n- MAPKK like protein kinase antibody\n- MAPKK-like protein kinase antibody\n- Nori 3 antibody\n- Nori-3 antibody\n- Nori3 antibody\n- PBK antibody\n- PDZ binding kinase antibody\n- PDZ-binding kinase antibody\n- Serine/threonine protein kinase antibody\n- Spermatogenesis related protein kinase antibody\n- Spermatogenesis-related protein kinase antibody\n- SPK antibody\n- T LAK cell originated protein kinase antibody\n- T-LAK cell-originated protein kinase antibody\n- TOPK antibody\n- TOPK_HUMAN antibody\nAnti-PBK antibody [EP2520Y] images\nOverlay histogram showing JEG3 cells stained with ab75987 (red line). The cells were fixed with 80% methanol (5 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab75987, 1/1000 dilution) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-rabbit IgG (H&L) (ab150077) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was rabbit IgG (monoclonal) (0.1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter. This antibody gave a positive signal in JEG3 cells fixed with 4% paraformaldehyde (10 min)/permeabilized with 0.1% PBS-Tween for 20 min used under the same conditions.\nAnti-PBK antibody [EP2520Y] (ab75987) at 1/500000 dilution + HeLa cell lysate at 10 µg\nHRP labelled goat anti-rabbit at 1/2000 dilution\nPredicted band size : 36 kDa\nObserved band size : 40 kDa (why is the actual band size different from the predicted?)\nImmunohistochemical analysis of paraffin-embedded human tonsil using ab75987 at 1/100 dilution.", "domain": "chemistry", "round": 3} +{"url": "https://www.selectscience.net/products/ultra-low-attachment-coated-polystyrene-surface/?prodID=83210", "date": "2020-09-29T06:46:41Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-40/segments/1600401632671.79/warc/CC-MAIN-20200929060555-20200929090555-00422.warc.gz", "language_score": 0.8789709210395813, "token_count": 252, "dump": "CC-MAIN-2020-40", "global_id": "webtext-fineweb__CC-MAIN-2020-40__0__9347375", "lang": "en", "text": "The Corning Ultra Low Attachment surface is a covalently bound hydrogel layer that is hydrophilic and neutrally charged.\nSince proteins and other biomolecules passively adsorb to polystyrene surfaces through either hydrophobic or ionic interactions, this hydrogel surface naturally inhibits nonspecific immobilization via these forces, thus inhibiting subsequent cell attachment. This surface is very stable, noncytotoxic, biologically inert and nondegradable.\nThe Ultra Low Attachment surface is useful for:\n• Growing primary cultures of tumor or normal cells as unattached spheroids\n• Studying activation and inactivation mechanisms of lymphocytes, monocytes, macrophages and other phagocytic cells\n• Research and procedures requiring the reduction of eukaryotic or microbial cell attachment\n• Preventing anchorage-dependent cells, such as fibroblasts, from attaching and dividing\n• Selectively culturing tumor or transformed cells as unattached colonies (substitute for soft agar assays)\n• Culturing cells, tissue or organ fragments in a stationary suspended, unattached state\n• Tissue engineering of easily harvested cell sheets and constructs using magnetic nanoparticles or liposomes", "domain": "chemistry", "round": 3} +{"url": "https://link.springer.com/article/10.1007%2Fs00702-007-0670-3", "date": "2019-07-22T03:34:54Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-30/segments/1563195527474.85/warc/CC-MAIN-20190722030952-20190722052952-00055.warc.gz", "language_score": 0.6589303016662598, "token_count": 615, "dump": "CC-MAIN-2019-30", "global_id": "webtext-fineweb__CC-MAIN-2019-30__0__92794585", "lang": "en", "text": "The aromatic cage in the active site of monoamine oxidase B: effect on the structural and electronic properties of bound benzylamine and p-nitrobenzylamine\n- 167 Downloads\nComputational studies using the ONIOM methods have been performed to probe the catalytic roles of tyrosine residues 398 and 435 which constitute the “aromatic cage” in the active site of MAO-B. The results presented here provide additional new insights into the interactions that take place on activation of the amine substrate by the aromatic cage residues in MAO-B catalysis and have relevance to the MAO-A catalytic mechanism.\n- Frisch MJ, Trucks GW, Schlegel HB, Scuseria GE, Robb MA, Cheeseman JR, Montgomery JA, Vreven T, Kudin KN, Burant JC, Millam JM, Iyengar SS, Tomasi J, Barone V, Mennucci B, Cossi M, Scalmani G, Rega N, Petersson GA, Nakatsuji H, Hada M, Ehara M, Toyota K, Fukuda R, Hasegawa J, Ishida M, Nakajima T, Honda Y, Kitao O, Nakai H, Klene M, Li X, Knox JE, Hratchian HP, Cross JB, Bakken Adamo VC, Jaramillo J, Gomperts R, Stratmann RE, Yazyev O, Austin AJ, Cammi R, Pomelli C, Ochterski JW, Ayala PY, Morokuma K, Voth GA, Salvador P, Dannenberg JJ, Zakrzewski VG, Dapprich S, Daniels AD, Strain MC, Farkas O, Malick DK, Rabuck AD, Raghavachari K, Foresman JB, Ortiz JV, Cui Q, Baboul AG, Clifford S, Cioslowski J, Stefanov BB, Liu G, Liashenko A, Piskorz P, Komaromi I, Martin RL, Fox DJ, Keith T, Al-Laham MA, Peng CY, Nanayakkara A, Challacombe M, Gill PMW, Johnson B, Chen W, Wong MW, Gonzalez C, Pople JA (2004) Gaussian 03, Revision C.02. Gaussian, Inc., Wallingford CTGoogle Scholar\n- Trickey, P, Basran, J, Lian, LY, Chen, Z, Barton, JD, Sutcliffe, MJ, Scrutton, NS, Mathews, FS 2000Structural and biochemical characterization of recombinant wild type and a C30A mutant of trimethylamine dehydrogenase from Methylophilus methylotrophus (sp. W(3)A(1))Biochemistry3976787688CrossRefPubMedGoogle Scholar", "domain": "chemistry", "round": 3} +{"url": "https://www.plant-ecology.com/EN/volumn/volumn_393.shtml", "date": "2021-03-03T02:37:14Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-10/segments/1614178365186.46/warc/CC-MAIN-20210303012222-20210303042222-00582.warc.gz", "language_score": 0.9360274076461792, "token_count": 815, "dump": "CC-MAIN-2021-10", "global_id": "webtext-fineweb__CC-MAIN-2021-10__0__112132591", "lang": "en", "text": "Aims Sonneratia apetala, a native mangrove species in India, Bengal and Sri-Lanka, was introduced in 1985 to Dongzhaigang Mangrove Nature Reserve in Hainan Island, China from Sundarban, southwest of Bangladesh. Laguncularia racemosa, another mangrove species from Mexico was introduced to the same reserve in 1999. Our objective was to investigate the salinity tolerance mechanism of S. apetala and L. racemosa in order to elucidate adaptive strategies of the halophytes in stressful saline habitat.\nMethods We investigated the effects of increasing soil NaCl (100-400 mmol·L-1) on gas exchange, O2-· production rate, activity of antioxidant enzymes, and the relevance to salt tolerance over four weeks in 1-year-old seedlings of S. apetala and L. racemosa.\nImportant findings Seedlings of the two mangrove species acclimated to different salinity levels through changing physiological and morphological traits. However, there were significant differences between S. apetala and L. racemosa in photosynthesis and anti-oxidant defense under salt stress. Increasing NaCl stress significantly elevated net photosynthetic rate (Pn), and stomatal conductance (Gs), intercellular CO2 concentration (Ci) and transpiration rate (Tr) decreased. As a result, water use efficiency (WUE) increased in leaves of S. apetala seedlings. But L. racemosa showed a rapid increase of Pn in the initiation of salt stress, and Pn remained lower than control levels at the end of the experiment. As a result, Ci and Gs increase with the decrease of Pn, Tr and WUE. The reduction occurred after exposure of L. racemosa seedlings to severe salinity, 400 mmol·L-1 NaCl (28 d). These results indicated that the inhibitory effects of severe salinity were more pronounced in L. racemosa under the same salinity. Moreover, the magnitude of variation of S. apetala maximum photochemical efficiency of PSII (Fv/Fm) was significantly less than that of L. racemosa leaves. We speculated that photosynthetic capacity of S. apetala was higher than L. racemosa. O2-· production rate markedly increased after the two seedlings were subjected to 100 mmol·L-1 NaCl and 200 mmol·L-1 NaCl for 7 days and 14 days, respectively. However, O2-· production rate in S. apetala leaves markedly increased upon increasing salinity and reached the highest level after seedlings were subjected to 400 mmol·L-1 NaCl for 28 days, which was 5.3 fold of that in controls. In contrast to S. apetala, O2 -· production rate in L. racemosa leaves remained lower than control levels at the end of the experiment. Activity of superoxide dismutase (SOD), ascorbate peroxidase (APX), catalase (CAT), peroxidase (POD) and glutathione reductase (GR) was elevated corresponding to the increased O2-· production in the salt-stressed two mangrove plants; however, the magnitude of increase of L. racemosa antioxidant enzyme activities was significantly greater than that of S. apetala, during the period of salt stress. We suggest that L. racemosa plants were able to sense salt stress and up-regulated the antioxidant enzymes to reduce salt-induced lipid peroxidation and membrane permeability, which contributed to maintenance of membrane integrity and salt tolerance in L. racemosa. Sonneratia apetala seedlings might adapt resistance to severe salinity through improving photosynthesis by higher WUE and maximum photochemical efficiency of PSII (Fv/Fm).", "domain": "chemistry", "round": 3} +{"url": "https://archive.bredl.org/alerts/hydrogensulfide042404.html", "date": "2023-03-24T19:58:42Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-14/segments/1679296945288.47/warc/CC-MAIN-20230324180032-20230324210032-00545.warc.gz", "language_score": 0.9070106744766235, "token_count": 361, "dump": "CC-MAIN-2023-14", "global_id": "webtext-fineweb__CC-MAIN-2023-14__0__118963540", "lang": "en", "text": "LETTERS NEEDED BY MID-MAY 2004\nUPDATE: The NC Rules Review Commission (RRC) received more than 10 letters objecting to the H2S exemptions for pulp and paper mills, thus sending the issue to the NC General Assembly. On June 17, 2004, industry lawyers argued that the RCC should rescind the approval of the new H2S AALs because the new rules should be considered as a \"package\". The RRC obliged and rescinded the new H2S rules. Discussions are underway . . . stay tuned. Thank you for your letters.\nWrite the NC Rules Review Commission to ask them to oppose NC Environmental Management Commissions exemption for Paper Mills from Hydrogen Sulfide Air Emissions Limits\nBackground: The North Carolina\nEnvironmental Management Commission has exempted\none of the largest sources of hydrogen sulfide\nemissions -- the waste ponds at paper mills. The\ncommission, by an 11-5 vote, granted paper mills\na permanent free pass from having to control the\nhydrogen sulfide fumes that rise off the\ntreatment ponds and give the air a distinctive\nrotten egg smell. Hydrogen sulfide, H2S, is formed by the\nbreakdown of organic materials and is typically\nfound near agricultural locations, waste\ntreatment plants and industrial sites. It is a\nknown carcinogen and neurotoxin, and can cause\ndevelopmental and reproductive harm to animals.\nDec. 15, 2003: BREDL additional comments on NC DAQ rulemaking for Hydrogen Sulfide limits.\nOct. 20, 2003: Factsheet: Hydrogen Sulfide - The Human Health Effect of a Toxic Pollutant.", "domain": "chemistry", "round": 3} +{"url": "http://celldeath.de/encyclo/index/u.htm", "date": "2023-10-01T09:47:37Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233510810.46/warc/CC-MAIN-20231001073649-20231001103649-00410.warc.gz", "language_score": 0.8774553537368774, "token_count": 413, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__150017157", "lang": "en", "text": "Ubiquitin is a highly conserved 76-residue protein of apparently all eukaryotic cells. It exists in a free form or as part of a branched, covalently linked protein-protein complex in which ubiquitin is attached by isopeptide formation at its C-terminus to the epsilon-amino groups of lysine side chains of acceptor proteins. This type of protein modification, termed ubiquitination, is known to mark proteins for degradation by the 26S proteasome. Ubiquitination can also target proteins to lysosomes by the endocytic route or mediate other regulatory functions (Hochstrasser, 1996, Annu. Rev. Genet., 405-39).\nUbiquitin-like modifiers (UBLs) are ubiquitin-like proteins which function as modifiers in a manner to that of ubiquitin, i.e. they exist either in a free form or , when catalysed by specific enzymes, attached covalently to other proteins by their C-termini. Examples are ubiquitin itself, SUMOs, and RUB1/NEDD8 (Jentsch and Pyrowolakis, 2000, Trends Cell. Biol., 10:335-42).\nUbiquitin-domain proteins (UDPs) contain domains that are related to ubiquitin but otherwise are unrelated in sequence to each other; in contrast to UBLs, these proteins are not conjugated to other proteins. Examples are RAD23, BAG-1, Scythe, and Parkin (Jentsch and Pyrowolakis, 2000, Trends Cell. Biol., 10:335-42).\nUsurpin is an alias for FLIP, the enzymatically inactive caspase-8 homolog, which can prevent receptor-mediated apoptosis More...\nHOME of Apoptopedia", "domain": "chemistry", "round": 3} +{"url": "https://solivare.com/product/chillgo-phenylephrine-paracetamol-chlorpheniramine/", "date": "2022-11-27T17:42:24Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-49/segments/1669446710417.25/warc/CC-MAIN-20221127173917-20221127203917-00273.warc.gz", "language_score": 0.895226001739502, "token_count": 259, "dump": "CC-MAIN-2022-49", "global_id": "webtext-fineweb__CC-MAIN-2022-49__0__107194254", "lang": "en", "text": "When a cold or allergy strikes\nprimarily used to treat symptoms of the common cold and allergies like sneezing, runny/stuffy nose, fever, headache, body pains, congestion, or watery eyes.\nChillGo is a combination of three drugs, namely: Paracetamol (mild analgesic and antipyretic), Phenylephrine (decongestant) and Chlorpheniramine (antihistamine/antiallergic). Paracetamol is an analgesic (relieves pain) and antipyretic (reduces fever) that works by inhibiting the production of certain chemical messengers in the brain known as prostaglandins that are responsible for pain and fever. Phenylephrine belongs to the class of decongestants that works by shrinking the blood vessels in the nasal passage. Thereby, provides relief from congestion and decreases the excess mucus production. Chlorpheniramine belongs to the class of antihistamines (anti-allergic drugs) that works by blocking the action of histamine, a substance responsible for causing allergic reactions. It helps to provide relief from symptoms of allergy such as sneezing, running nose, watery eyes, itching, swelling, and nasal congestion.", "domain": "chemistry", "round": 3} +{"url": "https://pubmed.ncbi.nlm.nih.gov/17434923/", "date": "2022-01-16T20:36:28Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-05/segments/1642320300010.26/warc/CC-MAIN-20220116180715-20220116210715-00656.warc.gz", "language_score": 0.9183902740478516, "token_count": 319, "dump": "CC-MAIN-2022-05", "global_id": "webtext-fineweb__CC-MAIN-2022-05__0__237632202", "lang": "en", "text": "Human N-acetyltransferase 2 (NAT2) is polymorphic in humans and may associate with cancer risk by modifying individual susceptibility to cancers from carcinogen exposure. Since molecular epidemiological studies investigating these associations usually include determining NAT2 single-nucleotide polymorphisms (SNPs), haplotypes or genotypes, their conclusions can be compromised by the uncertainty of genotype-phenotype relationships. We characterized NAT2 SNPs and haplotypes by cloning and expressing recombinant NAT2 allozymes in mammalian cells. The reference and variant recombinant NAT2 allozymes were characterized for arylamine N-acetylation and O-acetylation of N-hydroxy-arylamines. SNPs and haplotypes that conferred reduced enzymatic activity did so by reducing NAT2 protein without changing NAT2 mRNA levels. Among SNPs that reduced catalytic activity, G191A (R64Q), G590A (R197Q) and G857A (G286E) reduced protein half-life but T341C (I114T), G499A (E167K) and A411T (L137F) did not. G857A (G286E) and the major haplotype possessing this SNP (NAT2 7B) altered the affinity to both substrate and cofactor acetyl coenzyme A, resulting in reduced catalytic activity toward some substrates but not others. Our results suggest that coding region SNPs confer slow acetylator phenotype by multiple mechanisms that also may vary with arylamine exposures.", "domain": "chemistry", "round": 3} +{"url": "https://ph.vtlgbtcaucus.org/756-feldspar.html", "date": "2021-05-13T19:06:39Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-21/segments/1620243991943.36/warc/CC-MAIN-20210513173321-20210513203321-00161.warc.gz", "language_score": 0.9387252330780029, "token_count": 840, "dump": "CC-MAIN-2021-21", "global_id": "webtext-fineweb__CC-MAIN-2021-21__0__116926153", "lang": "en", "text": "other names: Spat\nmineral class: Framework silicates\nchemical formula: (Ba, Ca, Na, K, NH4) (Al, B, Si)4O8\nChemical elements: Barium, calcium, sodium, potassium, nitrogen, hydrogen, aluminum, boron, silicon\nSimilar minerals: ?\ncolour: pure feldspar is colorless or white\nshine: Glass gloss\ncrystal structure: monoclinic\nmass density: approx. 2.6\nmagnetism: not magnetic\nMohs hardness: 6,5\nstroke color: White\ntransparency: transparent to opaque\nuse: Porcelain production, gem stone\nGeneral information about feldspar:\nUnder the term feldspar are summarized several types of minerals, which are counted among the framework silicates. The name dates back to the 18th century and refers to their ability to easily split into fine spades when hitting them. All kinds of feldspar are not only their high cleavage but also their brittle to conchoid breakage and their striking glaze shine in common. Within the group, a distinction is made between the alkali feldspar or orthoclase, the soda-lime feldspar or plagioclase and the microlin, the group of so-called ternary feldspars, these three main types each being assigned to several subspecies.\nAll feldspar minerals are characterized as aluminosilicates by a three-dimensional network of tetrahedra, between which are arranged various positively charged cations. Their appearance is characterized by columnar or tabular crystals, which often occur in twinning. Depending on their location and chemical composition, they can either be transparent or opaque and show colors ranging from white to light pink, blue, green, red, orange or brown.\nFeldspates are formed both in magma rock and in sedimentary rock and in metamorphic rock types. Depending on the melt, the chemical elements and the temperatures, different types of feldspar may develop in the rock.\nIn addition to quartz and kaolin, feldspar has played an important role in the production of porcelain for millennia. As early as the Stone Age, people in the region of today's China knew various techniques for making ceramics and glazing them at a high level. From the Chou dynasty, which began around 1122 BC, came artful porcelain containers, which were produced in the province of Chekiang and were already covered with glazes from feldspar. These items have a characteristic yellowish, gray to greenish hue and are considered the direct precursors of the legendary celadon ceramic, which is still a high priority in China. Feldspar still plays an important role as one of the most important ingredients of glazes for porcelain and ceramic tiles and is also used in its pure form for the production of dentures.\nLocations and uses:\nAlso as gemstones are feldspar economically significant. The most beautiful specimens among the feldspars used in jewelry making include minerals belonging to the orthoclase group. The so-called moonstone with its characteristic milky and mostly light blue appearance and its shimmering in many colors surface is often honed as a cabochon. The most beautiful moonstones are found in the south of Sri Lanka, but also countries like Madagascar, Brazil, Burma, Australia, India and Tanzania produce worldwide coveted specimens of this dazzling orthoclase. In addition to the moonstone are still a second variety, namely known as sun stones plagioclase as gems particularly sought after. Already the Vikings and the natives of North America appreciated the crystals appearing in bright orange tones and attributed to them energetic potentials. The famous Oregon Sunstone has been officially recognized as a gemstone since the seventies of the last century. Ruby sun stones have been highly valued for several years. They come from Tibet and the Congo and are assigned to the group of Andesine.", "domain": "chemistry", "round": 3} +{"url": "https://www.lsbio.com/antibodies/anti-xrcc3-antibody-n-terminus-wb-western-ls-c95917/97294", "date": "2017-02-20T11:46:52Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-09/segments/1487501170521.30/warc/CC-MAIN-20170219104610-00211-ip-10-171-10-108.ec2.internal.warc.gz", "language_score": 0.8399928212165833, "token_count": 329, "dump": "CC-MAIN-2017-09", "global_id": "webtext-fineweb__CC-MAIN-2017-09__0__37916019", "lang": "en", "text": "The Immunohistochemistry Antibody Company\n|Human (tested or 100% immunogen sequence identity)|\n|XRCC3 antibody was raised against a synthetic peptide derived from the N-terminus of human XRCC3 protein.|\n|Reacts with a 32 kDa protein, known as XRCC3 (X-Ray Cross Complementing 3). XRCC3 is essential for repairing the double strand DNA breaks by homologous recombination between sister chromatids. It is homologous to Rad1. Five human homologues of RAD 51; XRCC2, XRCC3, RAD51B, RAD51C, RAD51D, interact among themselves to form one big complex or several smaller complexes.|\n|0.05% sodium azide|\n|Store at 2°C to 8°C degrees. Do not freeze.|\n|For research use only.|\nXRCC3 Antibody, DNA repair protein XRCC3 Antibody, CMM6 AntibodyInvolved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the RAD21 paralog protein complex CX3 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, CX3 acts downstream of RAD51 recruitment; the complex binds predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junctions of replication forks.", "domain": "chemistry", "round": 3} +{"url": "http://dbsy17.com/product/showproduct.php?id=19&lang=en", "date": "2020-10-23T03:11:26Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-45/segments/1603107880519.12/warc/CC-MAIN-20201023014545-20201023044545-00280.warc.gz", "language_score": 0.7552751302719116, "token_count": 411, "dump": "CC-MAIN-2020-45", "global_id": "webtext-fineweb__CC-MAIN-2020-45__0__52863923", "lang": "en", "text": "BSY-148A Automatic Gasoline Oxidation Stability Tester (Induction Period Method)|Automatic Gasoline Oxidation Stability Tester|Gasoline Oxidation Stability Tester|Gasoline Oxidation Stability|Petroleum Instrument|Testing Equipment\nThis instrument conforms to ASTM D525 GB/T8018 and is suitable for measuring the oxidation stability of gasoline under accelerated oxidation conditions. Adopting metal bath thermostatic technology can reduce the test cost and make it more environmentally friendly.\n1、Automation level: Industrial ARM32 bit patch core processor, automatic completion of the test process. Support online\nmonitoring, downloading, and more convenient to use.\n2、Control system: the industrial PLC programmable logic controller is adopted, and the three anti lacquer is treated to\nmake the instrument safe and comfortable. 7 inch tablet touch screen, without training, can be completed according to the\n3、Operating system: WindowsCE embedded operating system, the entire Chinese operation interface, the page arbitrary\nsimple and convenient operation, automatic printing results, large capacity storage function, can store tens of thousands\nof data and curves.\n4、Safety performance: automatic diagnosis, over temperature alarm, automatic cut-off of heater power supply, and test\ncompletion of alarm function.\n5、Metal bath thermostat Technology: save test cost and cleaner environment.\n1、Power supply: AC220V±10% 50Hz\n2、Machine power: 2200W\n3、Ambient temperature: 10~30℃\n4、Temperature range: Room temperature ~150℃\n5、Temperature control precision: 100±℃\n6、Pressure range: 0~1600kpa pressure transmitter: German import (Germany JUMO)\n7、Temperature sensor: Ptl00\n8 Metal bath two bombs are designed and 2 samples can be measured at the same time\n9 Shape Size: 660 * 400 * 350 (High)\n10 Weight: 40kg", "domain": "chemistry", "round": 3} +{"url": "https://www.cellsignal.com/products/3522.html", "date": "2014-03-11T15:43:50Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2014-10/segments/1394011219293/warc/CC-MAIN-20140305092019-00091-ip-10-183-142-35.ec2.internal.warc.gz", "language_score": 0.8395711779594421, "token_count": 495, "dump": "CC-MAIN-2014-10", "global_id": "webtext-fineweb__CC-MAIN-2014-10__0__79753220", "lang": "en", "text": "Product Pathways - Cell Cycle / Checkpoint\nPhospho-PNK1 (Ser114/Thr118) Antibody #3522\n|3522S||100 µl (10 western blots)||---||In Stock||---|\n|3522||carrier free and custom formulation / quantity||email request|\nAlready purchased this product? Write a Review.\nSpecies cross-reactivity is determined by western blot.\nApplications Key: W=Western Blotting\nSpecificity / Sensitivity\nPhospho-PNK1 (Ser114/Thr118) Antibody detects endogenous levels of PNK1 only when phosphorylated on Ser114 and Thr118.\nSource / Purification\nPolyclonal antibodies are produced by immunizing animals with a synthetic phosphopeptide corresponding to residues around Ser114 and Thr118 of human PNK1. Antibodies are purified by protein A and peptide affinity chromatography.\nPNK (polynucleotide kinase) is a DNA repair enzyme that participates in single strand break repair and non-homologous end rejoining (NHEJ) for double strand breaks. PNK possesses a 5'-DNA kinase activity and a 3'-DNA phosphatase activity (1,2). It has three domains, a C-terminal kinase domain, a central phosphatase domain, and an N-terminal forkhead associated (FHA) domain that is responsible for protein-protein interactions. Reduction in expression of PNK by RNAi sensitizes cells to ionizing radiation and topoisomerase I inhibitors (3)\nPhosphorylation of PNK1 at Ser114/ Thr118 was independently identified at Cell Signaling Technology (CST) using PhosphoScan®, CST's MS/MS platform for phosphorylation site discovery. Phosphorylation of PNK1 at Ser114/ Thr118 was observed in extracts of various cell lines following UV treatment. For additional information please visit PhosphoSitePlus®, CST's modification site knowledgebase, at www.phosphosite.org.\nHave you published research involving the use of our products? If so we'd love to hear about it. Please let us know!\nFor Research Use Only. Not For Use In Diagnostic Procedures.\nCell Signaling Technology® is a trademark of Cell Signaling Technology, Inc.", "domain": "chemistry", "round": 3} +{"url": "http://www.biomedcentral.com/1471-2121/5/22/abstract", "date": "2015-09-01T03:57:44Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2015-35/segments/1440645151768.51/warc/CC-MAIN-20150827031231-00065-ip-10-171-96-226.ec2.internal.warc.gz", "language_score": 0.8842669129371643, "token_count": 545, "dump": "CC-MAIN-2015-35", "global_id": "webtext-fineweb__CC-MAIN-2015-35__0__148439878", "lang": "en", "text": "Multisite phosphorylation of Pin1-associated mitotic phosphoproteins revealed by monoclonal antibodies MPM-2 and CC-3\nCREFSIP et Département de médecine, Pavillon Charles-Eugène-Marchand, Université Laval, Québec, Qc, Canada, G1K 7P4\nBMC Cell Biology 2004, 5:22 doi:10.1186/1471-2121-5-22Published: 1 June 2004\nThe peptidyl-prolyl isomerase Pin1 recently revealed itself as a new player in the regulation of protein function by phosphorylation. Pin1 isomerizes the peptide bond of specific phosphorylated serine or threonine residues preceding proline in several proteins involved in various cellular events including mitosis, transcription, differentiation and DNA damage response. Many Pin1 substrates are antigens of the phosphodependent monoclonal antibody MPM-2, which reacts with a subset of proteins phosphorylated at the G2/M transition.\nAs MPM-2 is not a general marker of mitotic phosphoproteins, and as most mitotic substrates are phosphorylated more than once, we used a different phosphodependent antibody, mAb CC-3, to identify additional mitotic phosphoproteins and eventual Pin1 substrates by combining affinity purification, MALDI-TOF mass spectrometry and immunoblotting. Most CC-3-reactive phosphoproteins appeared to be known or novel MPM-2 antigens and included the RNA-binding protein p54nrb/nmt55, the spliceosomal protein SAP155, the Ki-67 antigen, MAP-1B, DNA topoisomerases II α and β, the elongation factor hSpt5 and the largest subunit of RNA polymerase II. The CC-3 mitotic antigens were also shown to be Pin1 targets. The fine CC-3- and MPM-2-epitope mapping of the RNA polymerase II carboxy-terminal domain confirmed that the epitopes were different and could be generated in vitro by distinct kinases. Finally, the post-mitotic dephosphorylation of both CC-3 and MPM-2 antigens was prevented when cellular Pin1 activity was blocked by the selective inhibitor juglone.\nThese observations indicate that the mitotic phosphoproteins associated with Pin1 are phosphorylated on multiple sites, suggesting combinatorial regulation of substrate recognition and isomerization.", "domain": "chemistry", "round": 3} +{"url": "https://www.kth.se/profile/alvaroml/publications", "date": "2023-12-11T18:38:33Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679516047.98/warc/CC-MAIN-20231211174901-20231211204901-00579.warc.gz", "language_score": 0.7733091115951538, "token_count": 281, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__149809072", "lang": "en", "text": "Publications by Alvaro Morales Lopez\nA. Morales-Lopez et al., \"Impact of storage at different thermal conditions on surface characteristics of 3D printed polycaprolactone and poly(ε-caprolactone-co-p-dioxanone) scaffolds,\" Bioprinting, vol. 33, 2023.\nA. Morales Lopez, K. Marteleur and A. Finne Wistrand, \"Monitoring and classification of polymeric surface features for enabling the adoption of polypropylene powder bed fusion as a standard tool for bioprocessing equipment production,\" Additive Manufacturing, vol. 72, 2023.\nT. Kivijärvi et al., \"Hybrid material based on hyaluronan hydrogels and poly(L-lactide-co-1,3-trimethylene carbonate) scaffolds toward a cell-instructive microenvironment with long-term in vivo degradability,\" Materials Today Bio, vol. 17, pp. 100483, 2022.\nA. Ahlinder et al., \"Nondegradative additive manufacturing of medical grade copolyesters of high molecular weight and with varied elastic response,\" Journal of Applied Polymer Science, vol. 137, no. 15, 2020.\nSenaste synkning med DiVA:", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/insulin-receptor-beta-phospho-y1185-antibody-ab203278.html", "date": "2020-07-10T00:32:48Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-29/segments/1593655902377.71/warc/CC-MAIN-20200709224746-20200710014746-00334.warc.gz", "language_score": 0.7397136092185974, "token_count": 723, "dump": "CC-MAIN-2020-29", "global_id": "webtext-fineweb__CC-MAIN-2020-29__0__213933731", "lang": "en", "text": "Key features and details\n- Rabbit polyclonal to Insulin Receptor beta (phospho Y1185)\n- Suitable for: WB, IHC-P\n- Reacts with: Mouse, Rat, Human\n- Isotype: IgG\nProduct nameAnti-Insulin Receptor beta (phospho Y1185) antibody\nSee all Insulin Receptor beta primary antibodies\nDescriptionRabbit polyclonal to Insulin Receptor beta (phospho Y1185)\nTested applicationsSuitable for: WB, IHC-Pmore details\nSpecies reactivityReacts with: Mouse, Rat, Human\n- Human lung tissue.\nStorage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.\nStorage bufferPreservative: 0.09% Sodium azide\nConstituents: 50% Glycerol, 0.01% BSA\nConcentration information loading...\nPurityProtein A purified\nOur Abpromise guarantee covers the use of ab203278 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\n|WB||1/100 - 1/1000. Predicted molecular weight: 156 kDa.|\n|IHC-P||1/100 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.\nUse at 1/50 - 1/200 with fluorescent detection methods.\nRelevanceInsulin receptor mediates the biological activities of insulin by regulating multiple signaling pathways through activation of a series of phosphorylation cascades. The human insulin receptor is a heterotetrameric membrane glycoprotein consisting of disulfide-linked subunits in a ß-a-a-ß configuration. The ß-subunit (95kDa) possesses a single transmembrane domain with tyrosine kinase acivity, whereas the a-subunit (135kDa) is completely extracellular. The alpha subunits each contain insulin binding sites and are entirely extracellular in localization. The beta subunits each possess an extracellular domain, a single transmembrane domain, and a cytoplasmic tyrosine kinase domain. Binding of insulin to the alpha subunits induces a conformation change in the receptor which activates the kinase domain, stimulating tyrosine autophosphorylation of the receptor and tyrosine phosphorylation of at least five different insulin receptor substrates designated IRS-1-4, and Shc.\nCellular localizationMembrane; Single pass type I membrane protein.\n- CD220 antibody\n- HHF5 antibody\n- HIR B antibody\nImmunohistochemical analysis of formalin-fixed and paraffin embedded human lung tissue labeling Insulin Receptor beta (phospho Y1185) using ab203278 at 1/200, followed by secondary detection and DAB staining.\nImmunohistochemical analysis of formalin-fixed and paraffin embedded tissue labeling Insulin Receptor beta (phospho Y1185) using ab203278 at 1/200, followed by secondary detection and DAB staining.\nab203278 has not yet been referenced specifically in any publications.", "domain": "chemistry", "round": 3} +{"url": "http://link-springer-com-443.webvpn.fjmu.edu.cn/chapter/10.1007/978-1-4613-4223-6_26", "date": "2020-07-04T12:53:26Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-29/segments/1593655886121.45/warc/CC-MAIN-20200704104352-20200704134352-00469.warc.gz", "language_score": 0.7026304006576538, "token_count": 860, "dump": "CC-MAIN-2020-29", "global_id": "webtext-fineweb__CC-MAIN-2020-29__0__30647199", "lang": "en", "text": "Pattern of Purine-Nucleotide Metabolism in Hepatopancreas of Helix Pomatia (Gastropoda)\n- 90 Downloads\nIn 1970 Campbell and Bishop, describing the nitrogen metabolism in Moluscs, had written: “Terrestrial snails might thus serve as useful systems for investigating the specific derangements present in persons exhibiting the Lesch-Nyhan Syndrome” (1). For several years we have been concerned with the purine-nucleotide metabolism in land snail Helix pomatia (Pulmonata). This gastropod has been found to be purinotelic (11). During winter sleep, H. pomatia accumulates uric acid, which accounts for 75 % of the total purine content in the nephridium at the end of hibernation. During its active life, the nephridial excreta contain uric acid, xanthine and guanine, accounting for 34 – 49, 34 – 55 and 11 – 16 %, respectively of the total amount of purines excreted (12). An enzymic system allowing under normal, physiological conditions such diversity of the end-products of the nitrogen metabolism looked very promising. On the basis of investigations of the enzymes participating in the purine-nucleotide metabolism in the hepatopancreas, which is an organ homologous to the liver of Vertebrates, the scheme presented in Fig. 1. is suggested.\nKeywordsUric Acid Adenosine Kinase Terrestrial Snail Adenine Phosphoribosyltransferase Adenine Nucleotide Pool\nUnable to display preview. Download preview PDF.\n- 1.Campbell, J. W., Bishop, S. H. (1970) in “Comparative Biochemistry of Nitrogen Metabolism”, vol. I, pp. 103–206, ed. J. W. Campbell, Academic Press, London and New York.Google Scholar\n- 2.Barankiewicz J. (1973) Catabolism of IMP to uric acid in Helix pomatia (Gastropoda), Doctor’s Dissertation (in Polish). Inst. Biochem. Biophys., Polish Academy of Sciences, pp. 1–75.Google Scholar\n- 3.Barankiewicz, J. and Jeżewska, M. M. (1972). Bull. Acad. Pol. Scio Ser. sci. biol., 20, 1–4.Google Scholar\n- 4.Barankiewicz, J. and Jeżewska, M. M. (1973). Comp. Biochem. Physiol. 46B, 177–186.Google Scholar\n- 5.Barankiewicz, J. and Jeżewska, M. M. (1975). Comp. Biochem. Physiol., 52B, 239–244.Google Scholar\n- 6.Barankiewicz, J. and Jeżewska, M. M. (1976). Comp. Biochem. Physiol., 54B, 239–242.Google Scholar\n- 9.Jeżewska, M. M. and Barankiewicz, J. (1974). Abstracts 9th PEBS Meeting, s2e16, Budapest, Hungary.Google Scholar\n- 10.Jeżewska, M. M. and Barankiewicz, J. (1976). Bull. Acad. Polon. Sci., Ser. sci. biol., in press.Google Scholar\n- 13.Jeżewska, M. M., Gorzkowski, B. and Heller, J. (1964). Acta Biochim. Polon., 11, 135–138.Google Scholar\n- 14.Lowenstein, J. M. (1972). Physiol. Rev., 52, 382–414.Google Scholar\n- 15.Porembska, Z., Gorzkowski, B. and Jeżewska, M. M. (1964). Acta Biochim. Polon., 13, 107–111.Google Scholar", "domain": "chemistry", "round": 3} +{"url": "https://www.couponkirin.com/blog/resiners-cure-air-the-ultimate-resin-curing-machine-that-reduces-curing-time-by-92/", "date": "2023-06-08T01:36:13Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-23/segments/1685224654031.92/warc/CC-MAIN-20230608003500-20230608033500-00374.warc.gz", "language_score": 0.9154953956604004, "token_count": 725, "dump": "CC-MAIN-2023-23", "global_id": "webtext-fineweb__CC-MAIN-2023-23__0__154870925", "lang": "en", "text": "Say Goodbye to Long Curing Times and Hello to More Resin Crafts in Less Time\nAre you tired of waiting 24 hours for your epoxy resin to cure? Resin craft enthusiasts know the frustration of waiting for their resin crafts to cure. But with the Resiners Cure Air, the ultimate resin curing machine, you won’t have to wait that long anymore. It reduces curing time from 24 hours to just 2 hours! That’s a 92% reduction in curing time!\nIn this article, we’ll take a closer look at the Resiners Cure Air and its features and benefits. We’ll also discuss how it can help you create more resin crafts in less time. So, if you’re a resin craft enthusiast looking for a way to speed up your curing process, keep reading to learn more about the Resiners Cure Air.\nThe Resiners Cure Air has an upgraded tray in size, height, and stiffness. The dimension of the new tray is 188.8.131.52 inch, fit for resin molds under 1.8″ high. With a support under the center of the tray, it will be totally level and will not warp even when holding heavy resin molds. That means you can make bigger and better resin crafts without worrying about the tray warping.\nThe auto-curing feature is another game changer. You don’t have to set time and temperature manually anymore. With just a touch of the power button, the temperature will change automatically to cure resin evenly and finely in 2 hours. That means you can just press a button and let the Resiners Cure Air do the work for you.\nThe Resiners Cure Air cuts curing time from 24 hours to 2 hours. The machine provides a controlled environment for the curing process, ensuring a consistent and efficient cure, which will greatly accelerate epoxy resin curing. With the Resiners Cure Air, you can create more resin crafts in less time. That means you can make more money, too!\nThe Resiners Cure Air is also equipped with a transparent lid that allows you to see the wonderful fusion of different colors during the curing process. The cover also prevents dust or other drops from damaging your resin crafts. With the visualized curing process, you can watch your resin crafts come to life.\nThe Resiners Cure Air is suitable for most resin molds, like domino molds, jewelry molds, coaster molds, bookmark molds, pen molds, paw molds, etc. With its upgraded tray, it can accommodate molds under 1.8″ high, making it a versatile tool for resin craft enthusiasts. And it’s an original product that is patented, ensuring that you are getting a unique and high-quality product.\nAnd it’s an original product that is patented, ensuring that you are getting a unique and high-quality product.\nAccording to a survey conducted by Resiners, 90% of resin craft enthusiasts struggle with long curing times. The Resiners Cure Air is the solution to this problem. It reduces curing time from 24 hours to just 2 hours, making it a game changer for resin craft enthusiasts.\nIn conclusion, the Resiners Cure Air is the ultimate resin curing machine that will change the way you create resin crafts. With its upgraded tray, auto-curing feature, and visualized curing process, you can now create amazing works more easily and efficiently. Say goodbye to long curing times and hello to Resiners Cure Air! Get yours today and boost your creativity.", "domain": "chemistry", "round": 3} +{"url": "https://investigadores.unison.mx/es/publications/3d-microstructured-inorganic-perovskite-materials-for-thermal-neu", "date": "2022-12-02T19:13:25Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-49/segments/1669446710916.40/warc/CC-MAIN-20221202183117-20221202213117-00617.warc.gz", "language_score": 0.8113484978675842, "token_count": 273, "dump": "CC-MAIN-2022-49", "global_id": "webtext-fineweb__CC-MAIN-2022-49__0__169083974", "lang": "en", "text": "A combination of novel techniques such as a solvent-free thin-film deposition, perovskite patterning, and 10B back-fill technique enables the high neutron detection efficiency in a perovskite-based microstructured thermal neutron detector. High-efficiency cesium lead bromide (CsPbBr3) perovskite-based microstructured detectors are demonstrated here. Trenches up to 10 µm deep are etched into the CsPbBr3 thin films using a novel dry etching process involving a combination of HBr and Ar plasma. The microstructured diodes are then backfilled with isotopically enriched boron as neutron conversion material via a sedimentation process to preserve the perovskite integrity. The fabricated microstructured CsPbBr3 thermal neutron detectors show an efficiency of 4.3%. This represents >1.2x efficiency improvement over planar silicon (3.5%) and >2x efficiency improvement over planar CsPbBr3 (2.1%) detectors, respectively. More importantly, gamma-ray discrimination of 107 is measured in CsPbBr3-based microstructured neutron detectors.\nNota bibliográficaPublisher Copyright:\n© 2022 Wiley-VCH GmbH.", "domain": "chemistry", "round": 3} +{"url": "https://www.aeg.co.uk/support/support-articles/air-comfort/air-purifiers/what-data-does-the-air-purifier-measure/", "date": "2023-12-04T16:33:48Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100531.77/warc/CC-MAIN-20231204151108-20231204181108-00201.warc.gz", "language_score": 0.9122994542121887, "token_count": 630, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__26151355", "lang": "en", "text": "- What data does the air purifier measure? (PM 2.5, PM 1, PM 10, TVOC, humidity, temperature)\n- AEG AX9 series air purifiers\n- AEG AX7, AX5 series air purifiers\n- PURE 700 / 7000 series air purifiers\nDepending on the model purchased, you might have one or more sensors than what is described below.\nAs a standard, the WELL AX7/AX5 series and PURE 7000 series air purifiers come with an advanced laser PM sensor (Particulate Matter). This sensor can measure the following: PM10, PM2.5 and PM1.\nPM 2.5 are inhalable fine particles 2.5 μm (micrometre) or less in diameter that are potentially small enough to penetrate the bloodstream and impair immune response. PM 2.5 may include combustion particles, organic compounds and metal emissions.\nPM 1 are inhalable ultrafine particles 1 μm (micrometre) or less in diameter that are small enough to penetrate the bloodstream and reduce the oxygen-carrying capacity of the blood. PM 1 can remain in the air for days or weeks.\nPM 10 are inhalable coarse particles 10 μm (micrometre) or less in diameter that can inflame airways and lungs. PM10 may include dust, pollen and mould.\nIn addition, some Well AX7 also come equipped with a volatile organic compound (VOC) sensor, a temperature sensor as well as a humidity sensor - the measurement data from all of these sensors is available to view and track in the AEG App.\nTotal Volatile Organic Compounds (TVOC) are emitted gases from certain solids or liquids, including a variety of chemicals, that can accumulate in your home. Not all VOCs are harmful, many VOCs are relatively benign. For example, oranges and coffee beans emit VOCs.\nReduce VOCs in your home by opening windows or doors to allow air to circulate as well as reducing or removing products that bring VOCs into your home.\nTo get a more accurate reading, open a window to expose your air purifier to fresh air every once in a while. The TVOC sensor will self-calibrate every 24 hours or so. While recalibrating, TVOC data can be inaccurate or fluctuate\nHumidity is the amount of water vapour in the air. Bacteria, moulds, mildew and viruses can be reduced by keeping humidity between 30-50%\nYour air purifier can tell you how humid the air is but does not control humidity.\nTemperature refers to how hot or cold the air around your purifier is. For anyone with respiratory problems or allergies, the World Health Organization recommends a room temperature of no less than 16°C (61°F) and for the sick, disabled, very old or very young, a minimum of 20°C (68°F).\nYour air purifier can tell you the temperature, but it does not control the temperature.", "domain": "chemistry", "round": 3} +{"url": "https://portal.research.lu.se/portal/en/publications/a-review-of-in-situ-realtime-monitoring-techniques-for-membrane-fouling-in-the-biotechnology-biorefinery-and-food-sectors(dc67154b-ad45-4d91-9e02-e0b0b4332538).html", "date": "2019-10-16T15:08:29Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-43/segments/1570986668994.39/warc/CC-MAIN-20191016135759-20191016163259-00258.warc.gz", "language_score": 0.8886369466781616, "token_count": 327, "dump": "CC-MAIN-2019-43", "global_id": "webtext-fineweb__CC-MAIN-2019-43__0__98379246", "lang": "en", "text": "A review of in situ real-time monitoring techniques for membrane fouling in the biotechnology, biorefinery and food sectors\nResearch output: Contribution to journal › Article\nPressure-driven membrane processes are often used for the separation and purification of organic compounds originating from biomass. However, membrane fouling remains a challenge as these bio-based streams have a very complex composition and comprise a high fouling tendency. Conventional, the fouling is monitored based on either a decrease in flux or an increase in pressure over time. Those conventional techniques provide no information on the location, composition or amount of fouling. As fouling is often cumulative, it will be detected as a loss of performance. Once fouling becomes irreversible, it is often not possible to clean the membrane without chemicals and the filtration/separation process has to be stopped eventually. In situ real-time monitoring of membrane fouling could provide dynamic information on the development of fouling allowing optimization of the process. This paper reviews the state of the art in in situ monitoring techniques that could be applied to membrane processes in the biotechnology, biorefinery and food sectors and briefly reflects on the current awareness of in situ monitoring techniques among experienced industrial users of membrane processes. The physical principles as well as the strengths and weaknesses are addressed, as well as potentially and promising techniques are identified.\n|Research areas and keywords||\nSubject classification (UKÄ) – MANDATORY\n|Number of pages||26|\n|Journal||Journal of Membrane Science|\n|Publication status||Published - 2019 Oct 15|", "domain": "chemistry", "round": 3} +{"url": "http://qnetindia.com/dpt.php", "date": "2023-12-03T10:31:27Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100499.43/warc/CC-MAIN-20231203094028-20231203124028-00016.warc.gz", "language_score": 0.9030562043190002, "token_count": 1046, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__754971", "lang": "en", "text": "Dye Penetrant Testing\nDye penetrant inspection(DPI), also calledliquid penetrant inspection(LPI) orpenetrant testing(PT), is a widely applied and low-cost inspection method used to locate surface-breaking defects in allnon-porousmaterials (metals, plastics, or ceramics). The penetrant may be applied to all non-ferrous materials and ferrous materials, although for ferrous componentsmagnetic-particle inspectionis often used instead for its subsurface detection capability. LPI is used to detect casting, forging and welding surface defects such as hairline cracks, surfaceporosity, leaks in new products, andfatigue crackson in-service components.\nThe test surface is cleaned to remove any dirt, paint, oil, grease or any loose scale that could either keep penetrant out of a defect, or cause irrelevant or false indications. Cleaning methods may include solvents, alkaline cleaning steps,vapour degreasing, or media blasting. The end goal of this step is a clean surface where any defects present are open to the surface, dry, and free of contamination. Note that if media blasting is used, it may \"work over\" small discontinuities in the part, and an etching bath is recommended as a post-blasting treatment.\n2. Application of Penetrant:\nThe penetrant is then applied to the surface of the item being tested. The penetrant is allowed \"dwell time\" to soak into any flaws (generally 5 to 30 minutes). The dwell time mainly depends upon the penetrant being used, material being tested and the size of flaws sought. As expected, smaller flaws require a longer penetration time. Due to their incompatible nature one must be careful not to apply solvent-based penetrant to a surface which is to be inspected with a water-washable penetrant.\n3. Excess Penetrant Removal:\nThe excess penetrant is then removed from the surface. The removal method is controlled by the type of penetrant used. Water-washable, solvent-removable,lipophilicpost-emulsifiable, orhydrophilicpost-emulsifiable are the common choices.Emulsifiers represent the highest sensitivity level, and chemically interact with the oily penetrant to make it removable with a water spray. When using solvent remover and lint-free cloth it is important to not spray the solvent on the test surface directly, because this can remove the penetrant from the flaws. If excess penetrant is not properly removed, once the developer is applied, it may leave a background in the developed area that can mask indications or defects. In addition, this may also produce false indications severely hindering your ability to do a proper inspection. Also, the removal of excessive penetrant is done towards one direction either vertically or horizontally as the case may be.\n4. Application of Developer:\nAfter excess penetrant has been removed, a white developer is applied to the sample. Several developer types are available, including:non-aqueous wet developer, dry powder, water-suspendable, and water-soluble. Choice of developer is governed by penetrant compatibility (one can't use water-soluble or -suspendable developer with water-washable penetrant), and by inspection conditions. When using non-aqueous wet developer (NAWD) or dry powder, the sample must be dried prior to application, while soluble and suspendable developers are applied with the part still wet from the previous step. NAWD is commercially available in aerosol spray cans, and may employ acetone,isopropyl alcohol, or a propellant that is a combination of the two. Developer should form a semi-transparent, even coating on the surface.\nThe developer draws penetrant from defects out onto the surface to form a visible indication, commonly known as bleed-out. Any areas that bleed out can indicate the location, orientation and possible types of defects on the surface. Interpreting the results and characterizing defects from the indications found may require some training and/or experience [the indication size is not the actual size of the defect].\nThe inspector will use visible light with adequate intensity (100 foot-candlesor 1100 luxis typical) for visible dye penetrant. Ultraviolet (UV-A) radiation of adequate intensity (1,000 micro-watts per centimeter squared is common), along with low ambient light levels (less than 2 foot-candles) for fluorescent penetrant examinations. Inspection of the test surface should take place after 10- to 30-minute development time, depends of product kind. This time delay allows the blotting action to occur. The inspector may observe the sample for indication formation when using visible dye. It is also good practice to observe indications as they form because the characteristics of the bleed out are a significant part of interpretation characterization of flaws.\n6. Post Cleaning:\nThe test surface is often cleaned after inspection and recording of defects, especially if post-inspection coating processes are scheduled.\nWRITE TO US", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/cripto1cripto-antibody-epncir106a-hrp-ab203468.html", "date": "2019-12-13T03:06:33Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-51/segments/1575540548537.21/warc/CC-MAIN-20191213020114-20191213044114-00542.warc.gz", "language_score": 0.7891744375228882, "token_count": 705, "dump": "CC-MAIN-2019-51", "global_id": "webtext-fineweb__CC-MAIN-2019-51__0__31850594", "lang": "en", "text": "Product nameAnti-Cripto1/CRIPTO antibody [EPNCIR106A] (HRP)\nSee all Cripto1/CRIPTO primary antibodies\nDescriptionRabbit monoclonal [EPNCIR106A] to Cripto1/CRIPTO (HRP)\nTested applicationsSuitable for: WBmore details\nSpecies reactivityReacts with: Human\nSynthetic peptide within Human Cripto1/CRIPTO. The exact sequence is proprietary.\n(Peptide available as\n- WB: NCCIT whole cell lysate\nThis antibody was developed as part of a collaboration between Epitomics, the National Cancer Institute's Center for Cancer Research and the lab of David Solomon. View antibodies from NCI Center for Cancer Research Collaboration.\nThis product was previously labelled as Cripto1.\nOur RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents.\nStorage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C. Stable for 12 months at -20°C. Store In the Dark.\nStorage bufferpH: 7.40\nPreservative: 0.1% Proclin\nConstituents: 30% Glycerol, 1% BSA, PBS\nConcentration information loading...\nPurityProtein A purified\nOur Abpromise guarantee covers the use of ab203468 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\n|WB||1/5000. Detects a band of approximately 24 kDa (predicted molecular weight: 21 kDa).|\nFunctionCould play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm.\nTissue specificityPreferentially expressed in gastric and colorectal carcinomas than in their normal counterparts.\nSequence similaritiesContains 1 EGF-like domain.\nCellular localizationCell membrane.\n- Information by UniProt\n- CR antibody\n- CRGF antibody\n- Cripto 1 antibody\nAnti-Cripto1/CRIPTO antibody [EPNCIR106A] (HRP) (ab203468) at 1/5000 dilution + NCCIT (Human embryonic teratocarcinoma cell line) Whole Cell Lysate at 10 µg\nDeveloped using the ECL technique.\nPerformed under reducing conditions.\nPredicted band size: 21 kDa\nObserved band size: 24 kDa why is the actual band size different from the predicted?\nExposure time: 12 minutes\nThis blot was produced using a 4-12% Bis-tris gel under the MES buffer system. The gel was run at 200V for 35 minutes before being transferred onto a Nitrocellulose membrane at 30V for 70 minutes. The membrane was then blocked for an hour using 3% milk before being incubated with ab203468 overnight at 4°C. Antibody binding was visualised using ECL development solution ab133406.\nab203468 has not yet been referenced specifically in any publications.", "domain": "chemistry", "round": 3} +{"url": "http://www.abcam.com/Nestin-antibody-ab85684.html", "date": "2013-12-11T06:26:44Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2013-48/segments/1386164032243/warc/CC-MAIN-20131204133352-00056-ip-10-33-133-15.ec2.internal.warc.gz", "language_score": 0.7917683124542236, "token_count": 709, "dump": "CC-MAIN-2013-48", "global_id": "webtext-fineweb__CC-MAIN-2013-48__0__32524421", "lang": "en", "text": "Anti-Nestin antibody (ab85684)\n- Product nameAnti-Nestin antibodySee all Nestin primary antibodies ...\n- DescriptionRabbit polyclonal to Nestin\n- Tested applicationsWB, IP more details\n- Species reactivityReacts with: Human\nSynthetic peptide corresponding to a region between amino acids 325 and 375 of human Nestin (NP_006608.1).\n- Positive control\n- Whole cell lysate from HeLa cells\n- Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.\n- Storage bufferPreservative: 0.09% Sodium Azide\nConstituents: 0.1% BSA, Tris buffered saline\n- Concentration information loading...\n- PurityImmunogen affinity purified\n- Purification notesab85684 was affinity purified using an epitope specific to Nestin immobilized on solid support.\n- Clonality Polyclonal\nOur Abpromise guarantee covers the use of ab85684 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\nWB: 1/2000 - 1/10000. Predicted molecular weight: 177 kDa.\nNot yet tested in other applications.\nOptimal dilutions/concentrations should be determined by the end user.\n- FunctionRequired for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells.\n- Tissue specificityCNS stem cells.\n- Sequence similaritiesBelongs to the intermediate filament family.\n- Developmental stageUpon terminal neural differentiation, nestin is down-regulated and replaced by neurofilaments.\nmodificationsConstitutively phosphorylated. This increases during mitosis when the cytoplasmic intermediate filament network is reorganized.\n- ESTM 46 antibody\n- FLJ 21841 antibody\n- FLJ21841 antibody\n- Intermediate filament protein antibody\n- Nbla00170 antibody\n- Nes antibody\n- NEST_HUMAN antibody\n- Nestin antibody\nAnti-Nestin antibody images\nAll lanes : Anti-Nestin antibody (ab85684) at 0.04 µg/ml\nLane 1 : HeLa whole cell lysate at 50 µg\nLane 2 : HeLa whole cell lysate at 15 µg\nLane 3 : HeLa whole cell lysate at 5 µg\ndeveloped using the ECL technique\nPredicted band size : 177 kDa\nExposure time : 3 minutes\nNestin was immunoprecipitated using ab85684 at 10 µg/mg of whole cell lysate from HeLa cells.\n20% of the IP was loaded, and probed with ab85684 at 0.4 µg/ml.\nDetection: chemiluminescence with exposure time of 30 seconds.\nReferences for Anti-Nestin antibody (ab85684)\nab85684 has not yet been referenced specifically in any publications.", "domain": "chemistry", "round": 3} +{"url": "https://rjptonline.org/AbstractView.aspx?PID=2020-13-12-85", "date": "2021-01-18T21:13:30Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-04/segments/1610703515235.25/warc/CC-MAIN-20210118185230-20210118215230-00645.warc.gz", "language_score": 0.7919338345527649, "token_count": 3345, "dump": "CC-MAIN-2021-04", "global_id": "webtext-fineweb__CC-MAIN-2021-04__0__280836855", "lang": "en", "text": "Anshuman Rai, Anamika Gautam, Sakshi Panchal, Ankita Sood, Pankaj Prashar, Narendra Kumar Pandey, Indu Melkani, Bimlesh Kumar\nbimlesh1Pharm@gmail.com , email@example.com\nAnshuman Rai, Anamika Gautam, Sakshi Panchal, Ankita Sood, Pankaj Prashar, Narendra Kumar Pandey, Indu Melkani, Bimlesh Kumar*\nSchool of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India.\nVolume - 13,\nIssue - 12,\nYear - 2020\nThe plant Terminalia arjuna is claimed to be useful in the management of renal disorders. Recurrence of stone formation is the major concern worldwide due to partial and unsatisfactory relief. In the present study, the preventive and curative activity against kidney stones in urolithiatic rats was evaluated using bark of Terminalia arjuna. Preliminary phytochemical investigation using various test, estimation of phenolic and flavonoid content followed by antioxidant potential was also investigated. Invitro antiurolithiatic effect on artificial urine and in vivo effect in terms of curative and preventive potential on animals were reported. Urolithiasis was developed in rats by administration of ethylene glycol 0.75% v/v with 1% w/v ammonium chloride in drinking water. The ethanolic extract of T. arjuna at 200 and 400 mg/kg were administered to rat orally. Urine was collected from individual rats and used for investigation of various parameters like urine calcium, phosphate, oxalate and BUN. In serum, creatinine, calcium and uric acid levels were also estimated. The kidney homogenate was used for the estimation of oxidative biomarkers and histopathological reports. Terminalia arjuna bark extract showed the presence of tannin, terpenoids, saponin, flavonoids, glycosides, phenolic compounds, alkaloids etc and showed good amount of phenolic and flavonoid contents. The lithogenic induction caused impairment of renal function and oxidative stress, manifested as increased malondialdehyde, depleted reduced glutathione and decreased catalase activities of the kidneys, which were reversed by T. arjuna orally at both the doses in preventive as well as curative model. Thus, the current study revealed that the bark of Terminalia arjuna was endowed with antiurolithiatic activity possibly through an antioxidant.\nCite this article:\nAnshuman Rai, Anamika Gautam, Sakshi Panchal, Ankita Sood, Pankaj Prashar, Narendra Kumar Pandey, Indu Melkani, Bimlesh Kumar. Protective effect of Ethanolic extract of Terminalia arjuna bark against Ethylene Glycol induced Urolithiasis in male rats: In-Vitro and In-Vivo Evaluation. Research J. Pharm. and Tech. 2020; 13(12):6132-6139. doi: 10.5958/0974-360X.2020.01070.7\n1. S. Mitra, S. Gopumadhavan, M. Venkataranganna, and R. Sundaram, “Effect of cystone, a herbal formulation, on glycolic acid‐induced urolithiasis in rats,” Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives, vol. 12, no. 5, pp. 372-374. 1998.\n2. A. Makasana, V. Ranpariya, D. Desai, J. Mendpara, and V. Parekh, “Evaluation for the anti-urolithiatic activity of Launaea procumbens against ethylene glycol-induced renal calculi in rats,” Toxicology reports, vol. 1, pp. 46-52. 2014.\n3. A. P. Evan, “Physiopathology and etiology of stone formation in the kidney and the urinary tract,” Pediatric Nephrology, vol. 25, no. 5, pp. 831-841. 2010.\n4. Y. Bayir, Z. Halici, M. S. Keles, S. Colak, A. Cakir, Y. Kaya, and F. Akçay, “Helichrysum plicatum DC. subsp. plicatum extract as a preventive agent in experimentally induced urolithiasis model,” Journal of ethnopharmacology, vol. 138, no. 2, pp. 408-414. 2011.\n5. S. K. Gupta, M. S. Baghel, C. Bhuyan, B. Ravishankar, B. Ashok, and P. D. Patil, “Evaluation of anti-urolithiatic activity of Pashanabhedadi Ghrita against experimentally induced renal calculi in rats,” Ayu, vol. 33, no. 3, pp. 429. 2012.\n6. R. Ganesamoni, and S. K. Singh, \"Epidemiology of stone disease in Northern India,\" Urolithiasis, pp. 39-46: Springer, 2012.\n7. S. Jafar, L. Mehri, B. Hadi, and M. Jamshid, “The antiurolithiasic and hepatocurative activities of aqueous extracts of Petroselinum sativum on ethylene glycol-induced kidney calculi in rats,” Scientific Research and Essays, vol. 7, no. 15, pp. 1577-1583. 2012.\n8. M. M. Rane, and S. A. Mengi, “Comparative effect of oral administration and topical application of alcoholic extract of Terminalia arjuna bark on incision and excision wounds in rats,” Fitoterapia, vol. 74, no. 6, pp. 553-558. 2003.\n9. R. Chander, K. Singh, A. Khanna, S. Kaul, A. Puri, R. Saxena, G. Bhatia, F. Rizvi, and A. K. Rastogi, “Antidyslipidemic and antioxidant activities of different fractions ofTerminalia arjuna stem bark,” Indian Journal of Clinical Biochemistry, vol. 19, no. 2, pp. 141. 2004.\n10. K. Gauthaman, T. Mohamed Saleem, V. Ravi, P. Sita, and D. Niranjali, “Alcoholic Extract of Terminalia Arjuna Protects Rabbit Heart against Ischemic-Reperfusion Injury, Role of Antioxidant Enzymes and Heat Shock Protein,” World Acad Sci Eng Technol, vol. 18, pp. 488-98. 2008.\n11. H. A. Bachaya, Z. Iqbal, M. N. Khan, A. Jabbar, A. H. Gilani, and I.-u. Din, “In vitro and in vivo anthelmintic activity of Terminalia arjuna bark,” International Journal of Agriculture & Biology, vol. 11, pp. 273. 2009.\n12. A. Ram, P. Lauria, R. Gupta, P. Kumar, and V. Sharma, “Hypocholesterolaemic effects of Terminalia arjuna tree bark,” Journal of Ethnopharmacology, vol. 55, no. 3, pp. 165-169. 1997.\n13. M. Biswas, K. Biswas, T. K. Karan, S. Bhattacharya, A. K. Ghosh, and P. K. Haldar, “Evaluation of analgesic and anti-inflammatory activities of Terminalia arjuna leaf,” Journal of Phytology. 2011.\n14. M. A. Morshed, A. Uddin, A. Rahman, T. Hasan, S. Roy, A. Amin, R. Ahsan, and R. Islam, “In vitro antimicrobial and cytotoxicity screening of Terminalia arjuna ethanol extract,” International Journal of Biosciences, vol. 1, no. 2, pp. 31-38. 2011.\n15. P. Manna, M. Sinha, and P. C. Sil, “Aqueous extract of Terminalia arjuna prevents carbon tetrachloride induced hepatic and renal disorders,” BMC complementary and alternative medicine, vol. 6, no. 1, pp. 33. 2006.\n16. A. Chaudhary, S. Singla, and C. Tandon, “In vitro evaluation of Terminalia arjuna on calcium phosphate and calcium oxalate crystallization,” Indian journal of pharmaceutical sciences, vol. 72, no. 3, pp. 340. 2010.\n17. J. Burns, and B. Finlayson, “A proposal for a standard reference artificial urine in in vitro urolithiasis experiments,” Investigative urology, vol. 18, no. 2, pp. 167-169. 1980.\n18. G. P. Kumar, M. Arun, and K. Rishi, “Evaluation of Tinospora cordifolia for antiurolithiatic potential,” Journal of Pharmaceutical and Biomedical Sciences, vol. 9, no. 14, pp. 1-5. 2011.\n19. R. V. Karadi, N. B. Gadge, K. Alagawadi, and R. V. Savadi, “Effect of Moringa oleifera Lam. root-wood on ethylene glycol induced urolithiasis in rats,” Journal of ethnopharmacology, vol. 105, no. 1-2, pp. 306-311. 2006.\n20. K. Divakar, A. Pawar, S. Chandrasekhar, S. Dighe, and G. Divakar, “Protective effect of the hydro-alcoholic extract of Rubia cordifolia roots against ethylene glycol induced urolithiasis in rats,” Food and chemical toxicology, vol. 48, no. 4, pp. 1013-1018. 2010.\n21. A. Hodgkinson, “Determination of oxalic acid in biological material,” Clinical Chemistry, vol. 16, no. 7, pp. 547-557. 1970.\n22. N. Khan, J. Shinge, and N. Naikwade, “Antilithiatic effect of Helianthus annuus Linn. Leaf extract in ethylene glycol and ammonium chloride induced nephrolithiasis,” Int J Pharm Pharm Sci, vol. 2, no. 2010, pp. 181. 2010.\n23. S. Kaur, A. Rana, S. Gangwani, and R. Sharma, “Punica granatum attenuates sciatic nerve ligation induced-neuropathic pain,” International Journal of Pharmaceutical Sciences and Research, vol. 3, no. 2, pp. 509. 2012.\n24. G. Ellman, “Archs: Tissue sulfhydril groups,” Biochem Biophys, vol. 82, pp. 70-77. 1959.\n25. A. Ray, S. R. Chaudhuri, B. Majumdar, and S. K. Bandyopadhyay, “Antioxidant activity of ethanol extract of rhizome of Picrorhiza kurroa on indomethacin induced gastric ulcer during healing,” Indian Journal of Clinical Biochemistry, vol. 17, no. 2, pp. 44-51. 2002.\n26. M. Touhami, A. Laroubi, K. Elhabazi, F. Loubna, I. Zrara, Y. Eljahiri, A. Oussama, F. Grases, and A. Chait, “Lemon juice has protective activity in a rat urolithiasis model,” BMC urology, vol. 7, no. 1, pp. 18. 2007.\n27. A. Khajavi Rad, M.-A.-R. Hajzadeh, Z. Rajaei, M.-H. Sadeghian, N. Hashemi, and Z. Keshavarzi, “Preventive effect of Cynodon dactylon against ethylene glycol-induced nephrolithiasis in male rats,” Avicenna Journal of Phytomedicine, vol. 1, no. 1, pp. 14-23. 2011.\n28. A. Shukla, D. Mandavia, M. Barvaliya, S. Baxi, and C. Tripathi, “Anti-urolithiatic effect of cow urine Ark on ethylene glycol-induced Renal Calculi,” International braz j urol, vol. 39, no. 4, pp. 565-571. 2013.\n29. J. Fan, M. A. Glass, and P. S. Chandhoke, “Impact of ammonium chloride administration on a rat ethylene glycol urolithiasis model,” Scanning Microsc, vol. 13, no. 2-3, pp. 299-306. 1999.\n30. D. A. K. Chaitanya, M. Kumar, A. Reddy, N. Mukherjee, M. Sumanth, and A. Ramesh, “Anti urolithiatic activity of Macrotyloma uniflorum seed extract on ethylene glycol induced urolithiasis in albino rats,” J Innov Trends Pharm Sci, vol. 1, pp. 216-26. 2010.\n31. S. Bouanani, C. Henchiri, E. Migianu-Griffoni, N. Aouf, and M. Lecouvey, “Pharmacological and toxicological effects of Paronychia argentea in experimental calcium oxalate nephrolithiasis in rats,” Journal of ethnopharmacology, vol. 129, no. 1, pp. 38-45. 2010.\n32. A. Aggarwal, S. K. Singla, M. Gandhi, and C. Tandon, “Preventive and curative effects of Achyranthes aspera Linn. extract in experimentally induced nephrolithiasis.” 2012.\n33. P. Ashok, B. C. Koti, and A. Vishwanathswamy, “Antiurolithiatic and antioxidant activity of Mimusops elengi on ethylene glycol-induced urolithiasis in rats,” Indian journal of pharmacology, vol. 42, no. 6, pp. 380. 2010.\n34. S. B. SAYANA, V. R. CHAVAN, and R. MUDIUM, “Antilithiatic effect of Cissampelospareiraleaves in ammonium chloride and ethylene glycol induced urolithiasis in rats,” Asian J. Pharm. Clin. Res, vol. 7, pp. 103-106. 2014.", "domain": "chemistry", "round": 3} +{"url": "https://purerawz.co/product/otr-ac-tablets/", "date": "2022-05-20T04:13:10Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-21/segments/1652662531352.50/warc/CC-MAIN-20220520030533-20220520060533-00574.warc.gz", "language_score": 0.9077717661857605, "token_count": 304, "dump": "CC-MAIN-2022-21", "global_id": "webtext-fineweb__CC-MAIN-2022-21__0__177307881", "lang": "en", "text": "OTR-AC, also called MK-2866 Ester, is MK-2866 (Ostarine) which has undergone esterification during chemical synthesis to maximize the potency, bio distribution and half-life. The esterification of anabolic agents results in at least a 10-fold increase in half-life, which means that the active ingredient has the potential to remain bioactive ten times longer. Currently OTR-AC is being researched to prevent muscle wasting disease and increasing muscle mass. Each OTR-AC tablet contains 15mg.\n|Molar Mass||431.37 g/mol|\n|IUPAC Name||5-(1H-pyrazol-5-yl)-1-[2-[4-(trifluoromethoxy)phenoxy]ethyl]indole-2-carboxylic acid|\nBy completing and paying for your order, you agree to our Terms and Conditions. Customer satisfaction is our number one priority, if you are not 100% satisfied with the product you received, please contact us at firstname.lastname@example.org\nWe are not affiliated, associated, authorized, endorsed by, or in any way officially connected with SARMScentral.org, or any of its subsidiaries or its affiliates.", "domain": "chemistry", "round": 3} +{"url": "https://ibecbarcelona.eu/research/publications/?keyword=Quatsomes", "date": "2023-03-28T08:43:03Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-14/segments/1679296948817.15/warc/CC-MAIN-20230328073515-20230328103515-00414.warc.gz", "language_score": 0.8389858603477478, "token_count": 1218, "dump": "CC-MAIN-2023-14", "global_id": "webtext-fineweb__CC-MAIN-2023-14__0__195930943", "lang": "en", "text": "by Keyword: Quatsomes\nMartínez-Miguel M, Castellote-Borrell M, Köber M, Kyvik AR, Tomsen-Melero J, Vargas-Nadal G, Muñoz J, Pulido D, Cristóbal-Lecina E, Passemard S, Royo M, Mas-Torrent M, Veciana J, Giannotti MI, Guasch J, Ventosa N, Ratera I, (2022). Hierarchical Quatsome-RGD Nanoarchitectonic Surfaces for Enhanced Integrin-Mediated Cell Adhesion Acs Applied Materials & Interfaces 14, 48179-48193\nThe synthesis and study of the tripeptide Arg-Gly-Asp (RGD), the binding site of different extracellular matrix proteins, e.g., fibronectin and vitronectin, has allowed the production of a wide range of cell adhesive surfaces. Although the surface density and spacing of the RGD peptide at the nanoscale have already shown a significant influence on cell adhesion, the impact of its hierarchical nanostructure is still rather unexplored. Accordingly, a versatile colloidal system named quatsomes, based on fluid nanovesicles formed by the self-assembling of cholesterol and surfactant molecules, has been devised as a novel template to achieve hierarchical nanostructures of the RGD peptide. To this end, RGD was anchored on the vesicle's fluid membrane of quatsomes, and the RGD-functionalized nanovesicles were covalently anchored to planar gold surfaces, forming a state of quasi-suspension, through a long poly(ethylene glycol) (PEG) chain with a thiol termination. An underlying self-assembled monolayer (SAM) of a shorter PEG was introduced for vesicle stabilization and to avoid unspecific cell adhesion. In comparison with substrates featuring a homogeneous distribution of RGD peptides, the resulting hierarchical nanoarchitectonic dramatically enhanced cell adhesion, despite lower overall RGD molecules on the surface. The new versatile platform was thoroughly characterized using a multitechnique approach, proving its enhanced performance. These findings open new methods for the hierarchical immobilization of biomolecules on surfaces using quatsomes as a robust and novel tissue engineering strategy.\nJTD Keywords: activation, arg-gly-asp (rgd), cell adhesion, extracellular-matrix, growth, integrins, ligands, nanopatterns, quatsomes, scaffolds, self-assembled monolayers, surface engineering, tissue engineering, Arg-gly-asp (rgd), Cell adhesion, Integrins, Nano-structured surfaces, Nanovesicles, Quatsomes, Self-assembled monolayers, Surface engineering, Tissue engineering\nBoloix, A, Feiner-Gracia, N, Kober, M, Repetto, J, Pascarella, R, Soriano, A, Masanas, M, Segovia, N, Vargas-Nadal, G, Merlo-Mas, J, Danino, D, Abutbul-Ionita, I, Foradada, L, Roma, J, Cordoba, A, Sala, S, Toledo, JS, Gallego, S, Veciana, J, Albertazzi, L, Segura, MF, Ventosa, N, (2022). Engineering pH-Sensitive Stable Nanovesicles for Delivery of MicroRNA Therapeutics Small 18, 2101959\nMicroRNAs (miRNAs) are small non-coding endogenous RNAs, which are attracting a growing interest as therapeutic molecules due to their central role in major diseases. However, the transformation of these biomolecules into drugs is limited due to their unstability in the bloodstream, caused by nucleases abundantly present in the blood, and poor capacity to enter cells. The conjugation of miRNAs to nanoparticles (NPs) could be an effective strategy for their clinical delivery. Herein, the engineering of non-liposomal lipid nanovesicles, named quatsomes (QS), for the delivery of miRNAs and other small RNAs into the cytosol of tumor cells, triggering a tumor-suppressive response is reported. The engineered pH-sensitive nanovesicles have controlled structure (unilamellar), size (<150 nm) and composition. These nanovesicles are colloidal stable (>24 weeks), and are prepared by a green, GMP compliant, and scalable one-step procedure, which are all unavoidable requirements for the arrival to the clinical practice of NP based miRNA therapeutics. Furthermore, QS protect miRNAs from RNAses and when injected intravenously, deliver them into liver, lung, and neuroblastoma xenografts tumors. These stable nanovesicles with tunable pH sensitiveness constitute an attractive platform for the efficient delivery of miRNAs and other small RNAs with therapeutic activity and their exploitation in the clinics.\nJTD Keywords: cancer therapy, mirnas delivery, nanocarriers, nanovesicles, neuroblastoma, pediatric cancer, quatsomes, Biodistribution, Cancer therapy, Cell engineering, Cells, Cholesterol, Controlled drug delivery, Diseases, Dna, Dysregulated ph, Lipoplex, Microrna delivery, Mirnas delivery, Nanocarriers, Nanoparticles, Nanovesicle, Nanovesicles, Neuroblastoma, Neuroblastomas, Pediatric cancer, Ph sensitive, Ph sensors, Quatsome, Quatsomes, Rna, Sirna, Sirna delivery, Sirnas delivery, Small interfering rna, Small rna, Targeted drug delivery, Tumors, Vesicles", "domain": "chemistry", "round": 3} +{"url": "https://www.matec-conferences.org/articles/matecconf/abs/2018/98/matecconf_ts2018_01006/matecconf_ts2018_01006.html", "date": "2021-04-12T12:39:42Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-17/segments/1618038067400.24/warc/CC-MAIN-20210412113508-20210412143508-00596.warc.gz", "language_score": 0.8823792338371277, "token_count": 485, "dump": "CC-MAIN-2021-17", "global_id": "webtext-fineweb__CC-MAIN-2021-17__0__86000874", "lang": "en", "text": "MATEC Web Conf.\nVolume 239, 2018Siberian Transport Forum - TransSiberia 2018\n|Number of page(s)||5|\n|Section||Mechanical and Energy Transport Systems|\n|Published online||27 November 2018|\nModern technologies of a mineral material surface improvement for transport construction\n1 Emperor Alexander I St.-Petersburg State Transport University (PGUPS), Moskovsky pr. 9, St.-Petersburg, 190031, Russia\n2 St.-Petersburg State Institute of Technology (Technical University), Moskovsky pr. 26, St.-Petersburg, 190031, Russia\n* Corresponding author: firstname.lastname@example.org\nThe paper deals with technologies of a mineral material surface improvement for transport construction. Mineral surface is important because of its hardness, durability and other properties. Besides, it is necessary to protect it from aggressive environment. The purpose of the article is to introduce a few techniques of silica sol use in order to change mineral surface properties. The absorption, irrigation and watering processes were applied as the techniques. Both silica sol and its mixes with solutions contained Ca(II) ions were used as the substances. The experimental methods were carried out during the study. The experiment results have shown that hardness of the mineral material and foam concrete surface was increased up to 60% and the level of the soil strengthening was more than 0,5 MPa. It means that if silica sol and solutions containing Ca(II) ions are used a soil strength is increased more than 40-50%. The results of the study are particularly useful for construction of motorways in order to extend their service life.\n© The Authors, published by EDP Sciences, 2018\nThis is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.\nCurrent usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.\nData correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.\nInitial download of the metrics may take a while.", "domain": "chemistry", "round": 3} +{"url": "https://worldoflubricant.co.uk/products/liqui-moly-0w40-synthoil-energy-bmw-ll-mb-vw-porsche-ford-engine-oil-9515-5l", "date": "2024-02-21T14:11:02Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707947473518.6/warc/CC-MAIN-20240221134259-20240221164259-00315.warc.gz", "language_score": 0.8964319825172424, "token_count": 281, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__196560116", "lang": "en", "text": "Synthoil Energy SAE 0W-40 is a modern, fully synthetic, low friction motor oil for all season use. The combination of unconventional synthetic-based oils using advanced additive technology ensures low viscosity and high shear stability for the motor oil and reliably prevents the formation of deposits, reducing frictional loss in the engine and providing the optimal protection from wear. Synthoil Energy SAE 0W-40 is recommended for gasoline and Diesel engines, including engines with turbochargers and catalytic converters.\n- rapid oil delivery at low temperatures\n- outstanding engine cleanliness\n- high lubrication reliability\n- high wear resistance\n- highest fuel economy\n- low evaporation loss\n- tested for turbochargers and catalytic converters\n- outstanding high temperature stability\n- optimum oil pressure under all operating conditions\nSpecifications and approvals\nLIQUI MOLY also recommends this product for vehicles or assemblies for which the following specifications or original part numbers are required:\nFord WSS-M2C 937-A\nVW 502 00\nVW 505 00\nAreas of application\nOptimal for modern passenger vehicles with gasoline and diesel engines with and without turbochargers and with and without charge air cooling. Especially suitable where there are long intervals between oil changes and heavy duty engine requirements.\nThe operating instructions of the vehicle and engine manufacturers must be followed.", "domain": "chemistry", "round": 3} +{"url": "https://manualzz.com/doc/13308778/rub-off-msds", "date": "2020-09-30T21:49:56Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-40/segments/1600402128649.98/warc/CC-MAIN-20200930204041-20200930234041-00180.warc.gz", "language_score": 0.7558943033218384, "token_count": 1607, "dump": "CC-MAIN-2020-40", "global_id": "webtext-fineweb__CC-MAIN-2020-40__0__129983136", "lang": "en", "text": "MATERIAL SAFETY DATA SHEET Total Solutions P.O. Box 240014 Milwaukee, WI 53224 GENERAL INFORMATION NUMBER: (414) 354-6417 CHEMTREC: (800) 424-9300 REVISION DATE: November 9, 2004 DATE OF ISSUE: November 9, 2004 I - Product Identification MR 2 PRODUCT CODE: 0210 CHEMICAL FORMULATION: Powdered glass cleaner. NFPA HAZARD IDENTIFICATION SYSTEM: HEALTH: 2 HAZARD RATING: 4 - Extreme; 3 - High; FLAMMABILITY: 0 2 - Moderate; 1 - Slight; REACTIVITY: 0 0 - Insignificant II - Hazardous Ingredients SUBSTANCE Values reported as TWA unless noted. APPROX OSHA ACGIH EPA 40 CFR: % PEL TLV 302 355 372 Sodium Sulfate 30.0-40.0 N/E Sulfamic acid 15.0-25.0 N/E Crystalline silica N/E N/E 3 3 CAS # N N N 7757-82-6 N N N 5329-14-6 15.0-25.0 (0.1 mg/m ) (0.1 mg/m ) N N N 14808-60-7 10.0-20.0 1 mg/m3 1 mg/m3 N N N 144-62-7 1.00-10.0 3 N N N 68855-54-9 (respirable fraction) Oxalic acid Diatomaceous Earth Key: 6 mg/m 3 10 mg/m PEL: Permissible Exposure Limit TLV: Threshold Limit Value C: Ceiling level STEL: Short Term Exposure Limit N/A: Not Applicable N/D: Not Determined N/E: Not Established Y: Yes N: No 302: CERCLA List of Hazardous Substances and Reportable Quantities (40 CFR 302.4). 355: SARA TITLE III / List of Extremely Hazardous Substances for Emergency Planning and Notification (40 CFR 355). 372: SARA TITLE III / List of Toxic Chemicals subject to Release Reporting (Community Right to Know) (40 CFR 372). III - Physical Data BOILING POINT (°F): N/A SPECIFIC GRAVITY (WATER = 1): N/A VAPOR PRESSURE (mm Hg): N/A VOC CONTENT (% by weight): N/A VAPOR DENSITY (AIR = 1): N/A EVAPORATION RATE (WATER = 1): N/A SOLUBILITY IN WATER: Complete pH: N/D APPEARANCE AND ODOR: Free flowing off white powder, no odor. IV - Fire and Explosion Hazard Data FLASH POINT (°F): N/A (TEST METHOD): Closed cup FLAMMABLE LIMITS IN AIR (VOLUME %) UPPER: N/A LOWER: N/A EXTINGUISHING MEDIA: Water, foam, carbon dioxide, dry chemical. SPECIAL FIRE FIGHTING PROCEDURES: Cool fire exposed containers with water fog. Firefighters should be equipped with full protective gear including self-contained breathing apparatus. UNUSUAL FIRE AND EXPLOSION HAZARD: Foam or water may cause frothing. Emits highly toxic and irritating fumes in a fire. Closed containers exposed to heat may explode. PRODUCT NAME: MR2 PRODUCT CODE: 0210 V - Reactivity Data STABILITY: Stable INCOMPATIBILITY: Strong oxidizers and alkali, nitrates, nitrites, carbonates, sulfides, cyanides, sodium oxide, sulfur oxides. CONDITIONS TO AVOID: Extreme heat & aluminum. HAZARDOUS DECOMPOSITION PRODUCTS: Thermal decomposition may produce oxides of sulfur, nitrogen, ammonia & formic acid. HAZARDOUS POLYMERIZATION: Will not occur. CONDITIONS TO AVOID: None VI - Health Hazard Data ROUTES OF ENTRY INHALATION: X EYE CONTACT: X SKIN CONTACT: X INGESTION: X INGREDIENTS THAT ARE CONSIDERED BY OSHA, NTP, IARC TO BE SUSPECTED HUMAN CARCINOGENS: Crystalline silica (CAS #14808-60-7) EFFECTS OF OVEREXPOSURE IF IN EYES: Severe irritation & burns. Permanent damage may result. IF ON SKIN: Moderate to severe irritation. Prolonged skin contact may cause burns. IF SWALLOWED: Nausea, vomiting. May be harmful if swallowed. IF INHALED: Extremely harmful to mucous membranes and upper respiratory tract. Respirable crystalline silica can cause silicosis. EMERGENCY AND FIRST AID PROCEDURES IF IN EYES: Flush eyes and under eyelids with plenty of cool water for at least 15 minutes. If irritation persists, obtain medical attention. IF ON SKIN: Flush with water for 15 minutes while removing contaminated clothing. Launder clothing separately before reuse. If irritation persists, obtain medical attention. IF SWALLOWED: Contact physician or poison control center immediately. Give affected person 1 to 2 glasses of water. Do not induce vomiting unless instructed by a physician or poison control center. Never give anything by mouth to an unconscious person. IF INHALED: Remove person to fresh air. If breathing has stopped, administer artificial respiration. If breathing is difficult administer oxygen. VII - Spill or Leak Protection STEPS TO BE TAKEN IF MATERIAL IS RELEASED OR SPILLED: Ventilate area and remove all sources of ignition. Scoop up spilled material, avoiding generation of dust, and place in a properly marked closed container for proper disposal. WASTE DISPOSAL METHOD: Consult local environmental authorities. VIII - Special Protection Information RESPIRATORY PROTECTION: Use with adequate ventilation. Do not breathe dust. If recommended Exposure Limits are exceeded wear a NIOSH approved respirator, following manufacturer’s recommendations. VENTILATION LOCAL: Recommended MECHANICAL: Not required PROTECTIVE GLOVES: Chemical resistant. EYE PROTECTION: Safety glasses or goggles. OTHER PROTECTIVE EQUIPMENT: Eye wash station. PRECAUTIONS TO BE TAKEN IN HANDLING AND STORAGE: Store in a cool, dry place away from heat or open flame. Keep container tightly closed when not in use. OTHER PRECAUTIONS: Keep out of reach of children. IX - Transportation Information (ground transportation only) DOT PROPER SHIPPING NAME: Consumer Commodity DOT CLASS: ORM-D DOT ID NUMBER: None DOT PACKING GROUP: None The shipping information listed above applies only to non-bulk (< 119 gallons) containers of this product. This product may have more than one proper shipping name depending on packaging, product properties, & mode of shipment. If any alteration of packaging, product, or mode of transportation is further intended, different shipping names and labeling may apply. REVISION DATE: November 9, 2004 Prepared by: PMR DATE OF ISSUE: November 9, 2004 This information contained herein is based on data considered accurate. However, no warranty is expressed or implied regarding the accuracy of this data or the results to be obtained from the use thereof. Total Solutions assumes no responsibility for personal injury or property damage to the vendee, users or third parties caused by the material such vendees or users assume all risks associated with the use of this material.", "domain": "chemistry", "round": 3} +{"url": "https://www.antikoerper-online.de/abstract/Chemokine+(C-C+Motif)+Ligand+8+(CCL8)+ELISA+Kit/", "date": "2018-12-15T07:24:31Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-51/segments/1544376826800.31/warc/CC-MAIN-20181215061532-20181215083532-00404.warc.gz", "language_score": 0.6588377952575684, "token_count": 1789, "dump": "CC-MAIN-2018-51", "global_id": "webtext-fineweb__CC-MAIN-2018-51__0__175149713", "lang": "en", "text": "Use your antibodies-online credentials, if available.\nKeine Produkte auf Ihrer Vergleichsliste.\nIhr Warenkorb ist leer.\nCCL8 is one of several cytokine genes clustered on the q-arm of chromosome 17. Zusätzlich bieten wir Ihnen Chemokine (C-C Motif) Ligand 8 Antikörper (145) und Chemokine (C-C Motif) Ligand 8 Proteine (66) und viele weitere Produktgruppen zu diesem Protein an.\nShowing 10 out of 98 products:\nHuman CCL8 ELISA Kit für Sandwich ELISA - ABIN625040\nLiu, Liu, Chen, Chen, He, Zheng, Yang, Song, Weng, Hu, Fan, Xiao, Kaufmann, Ernst, Ge: Induction of CCL8/MCP-2 by mycobacteria through the activation of TLR2/PI3K/Akt signaling pathway. in PLoS ONE 2013\nShow all 12 Pubmed References\nHuman CCL8 ELISA Kit für Sandwich ELISA - ABIN1672741\nVan Coillie, Fiten, Nomiyama, Sakaki, Miura, Yoshie, Van Damme, Opdenakker: The human MCP-2 gene (SCYA8): cloning, sequence analysis, tissue expression, and assignment to the CC chemokine gene contig on chromosome 17q11.2. in Genomics 1997\nShow all 4 Pubmed References\nMouse (Murine) CCL8 ELISA Kit für Sandwich ELISA - ABIN365493\nWawegama, Markham, Elso, Kanci, Marenda, Browning, Brodnicki: Autoimmune-Disease-Prone NOD Mice Help To Reveal a New Genetic Locus for Reducing Pulmonary Disease Caused by Mycoplasma pulmonis. in Infection and immunity 2018\nHuman CCL8 ELISA Kit für Sandwich ELISA - ABIN1379902\nBlaszczyk, Coillie, Proost, Damme, Opdenakker, Bujacz, Wang, Ji: Complete crystal structure of monocyte chemotactic protein-2, a CC chemokine that interacts with multiple receptors. in Biochemistry 2000\nIt was shown that MCP2 was able to activate the NF-kappaB (zeige NFKB1 ELISA Kits) signaling pathway inducing the epithelial-mesenchymal transition (EMT (zeige ITK ELISA Kits)) and promoting the migration and invasion of ESCC cells in vitro.\nTranscriptome analysis identified several novel IPF-related genes. Among them, CCL8 is a candidate molecule for the differential diagnosis and prediction of survival.\nFindings exemplify how gradients of chemoattractive factors such as CCL8, drive metastasis and suggest that interference with their operation may provide means for breast cancer management.\nDetecting expression changes in TLR4 (zeige TLR4 ELISA Kits) and MCP2 in the peripheral blood is a feasible method for predicting the occurrence of abortion in women of child-bearing age\nDermal fibroblast CCL8 promotes melanoma metastasis.\nAuthors show that the previously observed downregulation of hsa (zeige CD24 ELISA Kits)-miR (zeige MLXIP ELISA Kits)-92a and upregulation of CCL8 during human cytomegalovirus latent infection of myeloid cells are intimately linked via the latency-associated expression of cytomegalovirus UL111A.\nCCL8 is an antimicrobial protein with bacteriocidal activity against E. coli.\nJAK2 (zeige JAK2 ELISA Kits) and STAT3 (zeige STAT3 ELISA Kits) activation is not essential for CCL3 (zeige CCL3 ELISA Kits), CCL5 (zeige CCL5 ELISA Kits) or CCL8 induced chemotaxis.\nResults indicate that the induction of MCP-2/CCL8 by mycobacteria is dependent on the activation of TLR2/PI3K (zeige PIK3CA ELISA Kits)/Akt (zeige AKT1 ELISA Kits) signaling pathway.\nMacrophage Colony Stimulating Factor (zeige CSF2 ELISA Kits) and Monocyte Chemoattractant Protein are elevated in sera of intrinsic asthmatics compared to normal controls.\ntumours are characterized by expression of inflammatory chemokines (CCL2 (zeige CCL2 ELISA Kits), CCL5 (zeige CCL5 ELISA Kits), CCL7 (zeige CCL7 ELISA Kits), CCL8, CCL12 (zeige Ccl12 ELISA Kits), CXCL9 (zeige CXCL9 ELISA Kits), CXCL10 (zeige CXCL10 ELISA Kits) and CX3CL1 (zeige CX3CL1 ELISA Kits)), reflected by an enrichment of activated Foxp3 (zeige FOXP3 ELISA Kits)(-) and Foxp3 (zeige FOXP3 ELISA Kits)(+) T cells\nthese data reveal an important role for BLIMP1 (zeige PRDM1 ELISA Kits) in modulating host defenses by suppressing expression of the chemokine (zeige CCL1 ELISA Kits) CCL8.\nResults indicate that the induction of MCP-2/CCL8 by mycobacteria is dependent on the activation of TLR2/PI3K/Akt (zeige AKT1 ELISA Kits) signaling pathway.\nData indicate mRNA upregulation of CCR2 (zeige CCR2 ELISA Kits) and CCR2 (zeige CCR2 ELISA Kits) ligands CCL2 (zeige CCL2 ELISA Kits), CCL7 (zeige CCL7 ELISA Kits), CCL8, and CCL12 (zeige Ccl12 ELISA Kits) in aortas from DOCA/salt-treated hypertension.\nVitamin B6 supplementation downregulates Cd8a (zeige CD8A ELISA Kits) and Ccl8 mRNA expression, so these candidate genes may play a protective role against colonic aberrant crypt foci development.\nearly and preclinical expression of CCL8 in plasma predicts overall survival of graft-vs.-host disease (GVHD) mice. Together with an involvement of allo-recognition in CCL8 expression, it suggests that CCL8 plays an important role in GVHD pathology.\nMCP (zeige CR1L ELISA Kits)/CCL8 was induced via STAT3 (zeige STAT3 ELISA Kits) and exhibited anti-tumor metastatic effect\npromotes atopic dermatitis by recruiting IL-5 (zeige IL5 ELISA Kits)+ Th2 cells\nCCL8 proteins were present in the vast majority of tissues investigated. mRNA for these proteins was also expressed in most of these tissues suggesting local production and the ability to respond in situ to inflammatory stimuli.\nThis gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes, lymphocytes, basophils and eosinophils. By recruiting leukocytes to sites of inflammation this cytokine may contribute to tumor-associated leukocyte infiltration and to the antiviral state against HIV infection.\nC-C motif chemokine 8\n, monocyte chemoattractant protein 2\n, monocyte chemotactic protein 2\n, small inducible cytokine subfamily A (Cys-Cys), member 8 (monocyte chemotactic protein 2)\n, small-inducible cytokine A8\n, monocyte chemoattractant protein-2\n, small inducible cytokine A8\n, monocyte chemotactic protein-2\n, small chemokine ligand 8\n, chemokine ligand 8", "domain": "chemistry", "round": 3} +{"url": "https://miami.pure.elsevier.com/en/publications/hydrogen-peroxide-release-by-mitochondria-from-normal-and-hypoxic", "date": "2022-05-21T00:02:13Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-21/segments/1652662534693.28/warc/CC-MAIN-20220520223029-20220521013029-00229.warc.gz", "language_score": 0.8914331197738647, "token_count": 441, "dump": "CC-MAIN-2022-21", "global_id": "webtext-fineweb__CC-MAIN-2022-21__0__306572176", "lang": "en", "text": "Ischemia/reperfusion mechanisms contribute to lung injury after transplantation, pulmonary embolism, and resolution of atelectasis. Alveolar tissue becomes hypoxic and deprived of substrate only when both ventilation and perfusion are interrupted, a situation modeled in vivo by complete, unilateral lung collapse. Because previously hypoxic mitochondria may be an important intracellular source of superoxide and hydrogen peroxide (H2O2) during reperfusion and re-oxygenation, the authors, in this study, investigated whether mitochondrial H2O2 release changed as a result of lung hypoxia/hypoperfusion resulting from collapse. Mitochondria were isolated from hypoxic (previously collapsed) right or contralateral left rabbits' lungs and from control rabbits' lungs. Mitochondrial H2O2 release, a marker of superoxide production, was measured fluorometrically after incubation with or without 1 mmol/L cyanide and 0.1 mmol/L nicotinamide adenine dinucleotide. Mitochondrial recovery was determined by assaying succinate dehydrogenase activity in mitochondrial preparations and lung homogenates. Lung succinate dehydrogenase activity and mitochondrial recovery were comparable among groups. Calculated lung mitochondrial content did not change (control subjects: left 7.9 ± 0.5, right 13.8 ± 1.7; hypoxic: left 10.3 ± 1.3, right 10.5 ± 2.4, all mg mitochondrial protein/lung). Mitochondria released hydrogen peroxide at approximately 5.6 nmol/h/mg pro in buffer alone and 14.8 nmol/h/mg pro in buffer with cyanide and nicotinamide adenine dinucleotide. However, lung collapse and resulting hypoxia caused no change in mitochondrial number or capacity to release H2O2 in vitro. Based on these findings, it is suggested that other sources of reactive oxygen metabolites, including xanthine oxidase and activated neutrophils, contribute to the oxidant injury observed in this model.\nASJC Scopus subject areas", "domain": "chemistry", "round": 3} +{"url": "https://karmaka.de/?p=6184", "date": "2023-06-08T02:47:03Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-23/segments/1685224654031.92/warc/CC-MAIN-20230608003500-20230608033500-00717.warc.gz", "language_score": 0.9024066925048828, "token_count": 487, "dump": "CC-MAIN-2023-23", "global_id": "webtext-fineweb__CC-MAIN-2023-23__0__48054365", "lang": "en", "text": "Microstructural evidence for a disequilibrium condensation origin for hibonite-spinel inclusions in the ALHA77307 CO3.0 chondrite\nHan, J., Brearley, A. J. and Keller, L. P.\nMeteoritics & Planetary Science. doi: 10.1111/maps.12563\n“Two hibonite-spinel inclusions (CAIs 03 and 08) in the ALHA77307 CO3.0 chondrite have been characterized in detail using the focused ion beam sample preparation technique combined with transmission electron microscopy. These hibonite-spinel inclusions are irregularly shaped and porous objects and consist of randomly oriented hibonite laths enclosed by aggregates of spinel with fine-grained perovskite inclusions finally surrounded by a partial rim of diopside. Melilite is an extremely rare phase in this type of CAI and occurs only in one inclusion (CAI 03) as interstitial grains between hibonite laths and on the exterior of the inclusion. The overall petrologic and mineralogical observations suggest that the hibonite-spinel inclusions represent high-temperature condensates from a cooling nebular gas. The textural relationships indicate that hibonite is the first phase to condense, followed by perovskite, spinel, and diopside. Texturally, melilite condensation appears to have occurred after spinel, suggesting that the condensation conditions were far from equilibrium. The crystallographic orientation relationships between hibonite and spinel provide evidence of epitaxial nucleation and growth of spinel on hibonite surfaces, which may have lowered the activation energy for spinel nucleation compared with that of melilite and consequently inhibited melilite condensation. Hibonite contains abundant stacking defects along the (001) plane consisting of different ratios of the spinel and Ca-containing blocks within the ideal hexagonal hibonite structure. This modification of the stacking sequence is likely the result of accommodation of excess Al in the gas into hibonite due to incomplete condensation of corundum from a cooling gas under disequilibrium conditions. We therefore conclude that these two hibonite-spinel inclusions in ALHA77307 formed by high-temperature condensation under disequilibrium conditions.”", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/pancreatic-lipaseptl-antibody-ab198181.html", "date": "2019-10-18T21:46:06Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-43/segments/1570986684854.67/warc/CC-MAIN-20191018204336-20191018231836-00108.warc.gz", "language_score": 0.7194383144378662, "token_count": 446, "dump": "CC-MAIN-2019-43", "global_id": "webtext-fineweb__CC-MAIN-2019-43__0__30764018", "lang": "en", "text": "Product nameAnti-Pancreatic Lipase/PTL antibody\nSee all Pancreatic Lipase/PTL primary antibodies\nDescriptionRabbit polyclonal to Pancreatic Lipase/PTL\nab198181 detects endogenous level of total Pancreatic Lipase/PTL protein.\nTested applicationsSuitable for: WBmore details\nSpecies reactivityReacts with: Mouse, Human\nPredicted to work with: Rat\nFusion protein within Human Pancreatic Lipase/PTL (internal sequence). The exact sequence is proprietary. Fusion protein corresponding to a region derived from internal residues of human Pancreatic Lipase/PTL. NCBI Accession No. BC014309. The identity of the protein fusion partner is GST.\nDatabase link: P16233\n- Mouse pancreas tissue lysate.\nPreviously labelled as Pancreatic Lipase.\nStorage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.\nStorage bufferpH: 7.3\nPreservative: 0.05% Sodium azide\nConstituents: 50% Glycerol, 49% PBS\nConcentration information loading...\nPurityImmunogen affinity purified\n- Pathways and Processes\n- Metabolic signaling pathways\n- Lipid and lipoprotein metabolism\n- Lipid metabolism\nOur Abpromise guarantee covers the use of ab198181 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\n|WB||1/400 - 1/2000. Predicted molecular weight: 51 kDa.|\nSequence similaritiesBelongs to the AB hydrolase superfamily. Lipase family.\nContains 1 PLAT domain.\n- Information by UniProt\n- lipase, pancreatic antibody\n- LIPP_HUMAN antibody\n- Pancreatic lipase antibody\nab198181 has not yet been referenced specifically in any publications.", "domain": "chemistry", "round": 3} +{"url": "https://www.bioscience.co.uk/product~70263", "date": "2020-07-03T17:40:05Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-29/segments/1593655882634.5/warc/CC-MAIN-20200703153451-20200703183451-00061.warc.gz", "language_score": 0.8180674314498901, "token_count": 308, "dump": "CC-MAIN-2020-29", "global_id": "webtext-fineweb__CC-MAIN-2020-29__0__109350623", "lang": "en", "text": "Antibody was affinity purified using an epitope specific to MOF/MYST1 immobilized on solid support. The epitope recognized by A300-994A maps to a region between residue 100 and 150 of human males absent on the first (MYST histone acetyltransferase 1) using the numbering given in entry BAB13924.1 (GeneID 84148). Immunoglobulin concentration was determined by extinction coefficient: absorbance at 280 nm of 1.4 equals 1.0 mg of IgG.\nhistone acetyltransferase KAT8, histone acetyltransferase MYST1, hMOF, K(lysine) acetyltransferase 8, Lysine acetyltransferase 8, MOF, MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1, MYST histone acetyltransferase 1, MYST1, MYST-1, ortholog of Drosophila males\nbetween 100 and 150\n2 - 8°C\nDetection of human MOF/MYST1 by western blot. Samples: Whole cell lysate (50 µg) from HEK293T and Jurkat cells. Antibodies: Affinity purified rabbit anti-MOF/MYST1 antibody A300-994A (lot A300-994A-2) used for WB at 1 µg/ml. Detection: Chemiluminescence with an exposure time of 3 minutes.", "domain": "chemistry", "round": 3} +{"url": "https://scicrunch.org/11923305/resource/nif-0000-11872", "date": "2017-03-28T19:48:34Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-13/segments/1490218189884.21/warc/CC-MAIN-20170322212949-00653-ip-10-233-31-227.ec2.internal.warc.gz", "language_score": 0.9031348824501038, "token_count": 486, "dump": "CC-MAIN-2017-13", "global_id": "webtext-fineweb__CC-MAIN-2017-13__0__109331087", "lang": "en", "text": "Mitotic activation of protein-tyrosine phosphatase alpha and regulation of its Src-mediated transforming activity by its sites of protein kinase C phosphorylation.\nDuring mitosis, the catalytic activity of protein-tyrosine phosphatase (PTP) alpha is enhanced, and its inhibitory binding to Grb2, which specifically blocks Src dephosphorylation, is decreased. These effects act synergistically to activate Src in mitosis. We show here that these effects are abrogated by mutation of Ser180 and/or Ser204, the sites of protein kinase C-mediated phosphorylation within PTPalpha. Moreover, either a Ser-to-Ala substitution or serine dephosphorylation specifically eliminated the ability of PTPalpha to dephosphorylate and activate Src even during interphase. This explains why the substitutions eliminated PTPalpha transforming activity, even though PTPalpha interphase dephosphorylation of nonspecific substrates was only slightly decreased. This occurred without change in the phosphorylation of PTPalpha at Tyr789, which is required for \"phosphotyrosine displacement\" during Src dephosphorylation. Thus, in addition to increasing PTPalpha nonspecific catalytic activity, Ser180 and Ser204 phosphorylation (along with Tyr789 phosphorylation) regulates PTPalpha substrate specificity. This involves serine phosphorylation-dependent differential modulation of the affinity of Tyr(P)789 for the Src and Grb2 SH2 domains. The results suggest that protein kinase C may participate in the mitotic activation of PTPalpha and Src and that there are intramolecular interactions between the PTPalpha C-terminal and membrane-proximal regions that are regulated, at least in part, by serine phosphorylation.\nPubmed ID: 11923305 RIS Download\n3T3 Cells | Animals | Catalysis | Enzyme Activation | Mice | Mitosis | Mutation | Nocodazole | Phosphorylation | Plasmids | Precipitin Tests | Protein Binding | Protein Kinase C | Protein Structure, Tertiary | Protein Tyrosine Phosphatases | Serine | Tyrosine | src Homology Domains | src-Family Kinases", "domain": "chemistry", "round": 3} +{"url": "http://okdb.appliedbioinfo.net/4_display.html?rec=3072", "date": "2018-06-24T01:14:28Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-26/segments/1529267865995.86/warc/CC-MAIN-20180624005242-20180624025242-00350.warc.gz", "language_score": 0.9297744035720825, "token_count": 584, "dump": "CC-MAIN-2018-26", "global_id": "webtext-fineweb__CC-MAIN-2018-26__0__61341686", "lang": "en", "text": "Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Diversification of these genes has occurred in regions encoding substrate-binding domains, as well as in tissue expression patterns, to accommodate an increasing number of foreign compounds.\nEarly embryo development\nExpression regulated by\nMaternal housekeeping proteins translated during bovine oocyte maturation and early embryo development. Massicotte L et al. Protein synthesis from maternal mRNA is needed to sustain oocyte maturation and embryo development prior to the maternal-embryonic transition (MET). Therefore, proteins that are expressed throughout this time are important and may be considered as maternal housekeeping proteins (MHKP). Our objectives were first, identify the translated protein patterns of bovine embryo development and secondly, determine the MHKP. Proteins synthesized during oocyte maturation and embryo development (2, 4 and 8-cell stages) were labeled using [S(35)]-Met and [S(35)]-Cys, and visualized by 2-DE. Embryos were cultured with alpha-amanitine to inhibit new transcription. Only 46 proteins were present throughout all stages. Ten spots were identified by MALDI-TOF and MS/MS: HSC71; HSP70; CypA; UCH-L1; GSTM5; Cct5; E-FABP; 2,3-BPGM, ubiquitin-conjugating enzyme E2D3; and beta-actin/gamma-actin. A new method called in silico protein identification confirmation was developed using EST databases. This method is a promising approach for use in rare tissue or from species with an incomplete protein database. This study has revealed that the translated protein patterns show a transition that brings the embryo to the MET. The needs in translated proteins between oocyte maturation and embryo development are different. In summary, this study represents the bases for future proteomics studies on bovine oocytes and embryos.", "domain": "chemistry", "round": 3} +{"url": "https://www.efsa.europa.eu/fr/efsajournal/pub/6142", "date": "2023-02-06T11:58:59Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-06/segments/1674764500339.37/warc/CC-MAIN-20230206113934-20230206143934-00574.warc.gz", "language_score": 0.9625350832939148, "token_count": 376, "dump": "CC-MAIN-2023-06", "global_id": "webtext-fineweb__CC-MAIN-2023-06__0__232212762", "lang": "en", "text": "Panel members at the time of adoption\nFollowing a request from the European Commission, the EFSA Panel on Additives and products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy of APSA PHYTAFEED® 20,000 GR/L (6‐phytase) as a zootechnical feed additive for laying hens and other poultry species for laying. The additive is a preparation of 6‐phytase produced by a genetically modified strain of Komagataella phaffii and has been previously assessed by the FEEDAP Panel in the context of three applications for its use in different species/categories. The Panel concluded in those opinions that the production strain is safe, and that the use of the additive as a feed additive would raise no safety concerns for the consumers and the environment. The additive was also considered not to be irritant to skin or eyes or a dermal sensitiser but it should be considered as a respiratory sensitiser. The Panel considered that the new use in laying hens and other poultry species for laying would not modify the previously drawn conclusions with respect to the consumers, users and the environment. A tolerance trial in laying hens and a subchronic oral toxicity study were made available to support the safety of the additive for the target species/categories subject of this new application; from the results obtained, the Panel concluded that the additive is safe for laying hens at the recommended level of use (300 U/kg feed) with a wide margin of safety and therefore the conclusion was extrapolated to other laying birds. The FEEDAP Panel concluded that the additive has the potential to be efficacious in laying hens at the level of 300 U/kg feed and this conclusion was extrapolated to other laying birds.", "domain": "chemistry", "round": 3} +{"url": "https://www.tcichemicals.com/GB/en/p/T0961", "date": "2023-12-01T10:44:58Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100286.10/warc/CC-MAIN-20231201084429-20231201114429-00881.warc.gz", "language_score": 0.6918428540229797, "token_count": 573, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__44975217", "lang": "en", "text": "CAS RN: 68254-41-1 | Product Number: T0961\n3-(Trifluoromethyl)phenyltrimethylammonium Hydroxide (5% in Methanol) [for Transesterification of Glyceride]\n*Stock available in Belgium will be delivered in 1 to 3 days\n*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).\n|Appearance||Colorless to Almost colorless clear liquid|\n|Concentration(Neutralization titration)||5.0 to 5.5 w/w%|\n|High boiling impurities||to pass test|\n|Hazard Statements||H311 + H331 : Toxic in contact with skin or if inhaled.\nH314 : Causes severe skin burns and eye damage.\nH360 : May damage fertility or the unborn child.\nH370 : Causes damage to organs.\nH372 : Causes damage to organs through prolonged or repeated exposure.\nH335 : May cause respiratory irritation.\nH336 : May cause drowsiness or dizziness.\nH225 : Highly flammable liquid and vapour.\n|Precautionary Statements||P260 : Do not breathe dust/ fume/ gas/ mist/ vapours/ spray.\nP210 : Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.\nP201 : Obtain special instructions before use.\nP280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.\nP370 + P378 : In case of fire: Use dry sand, dry chemical or alcohol-resistant foam to extinguish.\nP308 + P311 : IF exposed or concerned: Call a POISON CENTER/doctor.\nP303 + P361 + P353 : IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water.\nP304 + P340 + P310 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/doctor.\nP305 + P351 + P338 + P310 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER/doctor.\nP403 + P233 : Store in a well-ventilated place. Keep container tightly closed.\n|Class||3 / 8|\nSafety Data Sheet (SDS)\nThe requested SDS is not available.\nPlease Contact Us for more information.\nC of A & Other Certificates\nThe requested analytical chart is not available. Sorry for the inconvenience.", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/pbld-antibody-ab235947.html", "date": "2020-10-26T02:03:23Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-45/segments/1603107890108.60/warc/CC-MAIN-20201026002022-20201026032022-00437.warc.gz", "language_score": 0.6754165291786194, "token_count": 652, "dump": "CC-MAIN-2020-45", "global_id": "webtext-fineweb__CC-MAIN-2020-45__0__134067517", "lang": "en", "text": "Key features and details\n- Rabbit polyclonal to PBLD\n- Suitable for: IHC-P, WB\n- Reacts with: Mouse, Human\n- Isotype: IgG\nProduct nameAnti-PBLD antibody\nDescriptionRabbit polyclonal to PBLD\nTested applicationsSuitable for: IHC-P, WBmore details\nSpecies reactivityReacts with: Mouse, Human\nPredicted to work with: Orangutan\nRecombinant fragment corresponding to Human PBLD aa 11-288.\nFTARAFRGNPAAVCLLENELDEDMHQKIAREMNLSETAFIRKLHPTDNFA QSSCFGLRWFTPASEVPLCGHATLASAAVLFHKIKNMNSTLTFVTLSGEL RARRAEDGIVLDLPLYPAHPQDFHEVEDLIKTAIGNTLVQDICYSPDTQK LLVRLSDVYNRSFLENLKVNTENLLQVENTGKVKGLILTLKGEPGGQTQA FDFYSRYFAPWVGVAEDPVTGSAHAVLSSYWSQHLGKKEM\nDatabase link: P30039\n- WB: Mouse kidney and liver tissue lysates. IHC-P: Human kidney tissue.\nStorage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.\nStorage bufferpH: 7.40\nConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.03% Proclin 300\nConcentration information loading...\nPurityProtein G purified\nPurification notesPurity >95%.\nOur Abpromise guarantee covers the use of ab235947 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\n|IHC-P||1/20 - 1/200.|\n|WB||1/500 - 1/2000.|\nSequence similaritiesBelongs to the phzF family.\n- Information by UniProt\n- FLJ14767 antibody\n- FLJ35507 antibody\n- MAWBP antibody\nAll lanes : Anti-PBLD antibody (ab235947) at 1/500 dilution\nLane 1 : Mouse liver tissue lysate\nLane 2 : Mouse kidney tissue lysate\nAll lanes : Goat polyclonal to Rabbit IgG at 1/10000 dilution\nParaffin-embedded human kidney tissue stained for PBLD using ab235947 at 1/100 dilution in immunohistochemical analysis.\nTo our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.\nab235947 has not yet been referenced specifically in any publications.", "domain": "chemistry", "round": 3} +{"url": "https://shop.elsevier.com/books/hemoglobins-part-b-biochemical-and-analytical-methods/abelson/978-0-12-182132-6", "date": "2023-11-28T23:39:57Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100016.39/warc/CC-MAIN-20231128214805-20231129004805-00471.warc.gz", "language_score": 0.7146419286727905, "token_count": 1577, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__283542789", "lang": "en", "text": "Preparation, Purification, and Analysis of Human Hemoglobin:\nR.M. Winslow and K.W. Chapman, Pilot-Scale Preparation of Hemoglobin Solutions.\nB.J.-M. Thevenin and S.B. Shohet, Detection of Red Cell Membrane Components in Human Hemoglobin Preparations.\nB. Masala and L. Manca, Detection of Globin Chains by Reversed-Phase High-Performance Liquid Chromatography.\nP. Ferranti, A. Malorni, and P. Pucci, Structural Characterization of Hemoglobin Variants Using Capillary Electrophoresis and Fast Atom Bombardment Mass Spectrometry.\nM.P. Cohen and V.-Y. Wu, Purification of Glycated Hemoglobin.\nR.I. Roth and J. Levin, Measurement of Endotoxin Levels in Hemoglobin Preparations.\nPreparation and Characterization of Nonhuman Hemoglobins:\nH.H. Ruf, A.G. Altemaller, and K. Gersonde, Preparation and Characterization of Insect Hemoglobins from Chironomus thummi thummi.\nS.N. Vinogradov and P.K. Sharma, Preparation and Characterization of Invertebrate Globin Complexes.\nA. DeYoung, L.D. Kwiatkowski, and R.W. Noble, Fish Hemoglobins.\nC. Fronticelli and E. Bucci, Conformational and Functional Characteristics of Bovine Hemoglobin.\nHemoglobin Hybrids and Model Hemes:\nE. Tsuchida and T. Komatsu, Synthetic Hemes.\nR.P. Roy and A.S. Acharya, Semisynthesis of Hemoglobin.\nA. Tsuneshige and T. Yonetani, Preparation of Mixed Metal Hybrids.\nChemically Modified Hemoglobins:\nJ.M. Manning, Preparation of Hemoglobin Derivatives Selectively or Randomly Modified at Amino Groups.\nM.J. Rao and A.S. Acharya, Amidation of Basic Carboxyl Groups of Hemoglobin.\nR.E. Benesch, Bis(pyridoxal) Polyphosphates as Specific Intramolecular Cross-Linking Agents for Hemoglobin.\nR.Y. Walder, M.E. Andracki, and J.A. Walder, Preparation of Intramolecularly Cross-Linked Hemoglobins.\nD.L. Currell, Derivatives of Hemoglobin Prepared by Reaction with Aryl or Alkyl Isothiocyanates.\nS.L. MacDonald and D.S. Pepper, Hemoglobin Polymerization.\nH. Xue and J. T.-F. Wong, Preparation of Conjugated Hemoglobins.\nR.T. Jones, Structural Characterization of Modified Hemoglobins.\nT.-H. Jessen, N.H. Komiyama, J. Tame, J. Pagnier, D. Shih, B. Luisi, G. Fermi, and K. Nagai, Production of Human Hemoglobin in Escherichia coli Using Cleavable Fusion Protein Expression Vector.\nD. Looker, A.J. Mathews, J.O. Neway, and G.L. Stetler, Expression of Recombinant Human Hemoglobin in Escherichia coli.\nJ.E. Ogden, R. Harris, and M.T. Wilson, Production of Recombinant Human Hemoglobin A in Saccharomyces cerevisiae.\nJ.J.M. de Llano, O. Schneewind, G.L. Stetler, and J.M. Manning, Purification and Characterization of Recombinant Human Sickle Cell Hemoglobin Expressed in Yeast.\nM.P. Reilly, S.L. McCune, T.M. Ryan, T.M. Townes, M. Katsumata, and T. Asakura, Preparation of Recombinant Hemoglobin in Transgenic Mice.\nJ.S. Logan and M.J. Martin, Transgenic Swine as Recombinant Production System for Human Hemoglobin.\nHemoglobin Stability and Degradation:\nJ.M. Rifkind, O. Abugo, A. Levy, and J. Heim, Detection, Formation, and Relevance of Hemichromes and Hemochromes.\nV.W. Macdonald, Measuring Relative Rates of Hemoglobin Oxidation and Denaturation.\nC. Giulivi and K.J.A. Davies, Hydrogen Peroxide-Mediated Ferrylhemoglobin Generation in Vitro and in Red Blood Cells.\nR.E. Benesch, The Stability of the Heme-Globin Linkage: Measurement of Heme Exchange.\nS.S. Panter, Release of Iron from Hemoglobin.\nK.W. Olsen, Thermal Denaturation Procedures for Hemoglobin.\nJ. Everse, Photochemical Reduction of Methemoglobin and Methemoglobin Derivatives.\nE.L. McGown, M. Khan, and K.Dill, Regeneration of Functional Hemoglobin from Partially Oxidized Hemoglobin in the Presence of Molecular Hydrogen and a Multicomponent Redox Catalyst.\nEnzymatic Reactions Catalyzed by Hemoglobin:\nJ. Everse, M.C. Johnson, and M.A. Marini, Peroxidative Activities of Hemoglobin and Hemoglobin Derivatives.\nL. Zilletti, M. Ciuffi, S. Franchi-Micheli, F. Fusi, G. Gentilini, G. Moneti, M. Valoti, and G.P. Sgaragli, Cyclooxygenase Activity of Hemoglobin.\nJ.J. Mieyal and D.W. Starke, Hydroxylation and Dealkylation Reactions Catalyzed by Hemoglobin.\nG. Belvedere and M. Samaja, Oxidation of Olefins Catalyzed by Hemoglobin.\nXenobiotic Adducts of Human Hemoglobin:\nS.R. Tannenbaum and P.L. Skipper, Quantitative Analysisof Hemoglobin-Xenobiotic Adducts.\nJ.S. Wishnok, Quantitative Mass Spectrometry of Hemoglobin Adducts.\nP.L. Skipper and W.G. Stillwell, Aromatic Amine-Hemoglobin Adducts.\nM. Tirnqvist, Epoxide Adducts to N-Terminal Valine of Hemoglobin.\nS.S. Hecht, S.G. Carmella, and S.E. Murphy, Tobacco-Specific Nitrosamine-Hemoglobin Adducts.\nK. Taghizadeh and P.L. Skipper, Benzo[a]pyrene Diol Epoxide and Related Polynuclear Aromatic Hydrocarbon Adducts of Hemoglobin.\nB.W. Day and K. Singh, Analysis of Hemoglobin Adducts by Fluorescence Spectroscopy.\nE. Tsuchida and T. Komatsu, Addendum to Article .", "domain": "chemistry", "round": 3} +{"url": "https://www.polifar.com/What-is-the-future-trend-of-L-lysine-hydrochloride-id3025811.html", "date": "2021-07-29T13:24:38Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-31/segments/1627046153857.70/warc/CC-MAIN-20210729105515-20210729135515-00289.warc.gz", "language_score": 0.9405498504638672, "token_count": 1184, "dump": "CC-MAIN-2021-31", "global_id": "webtext-fineweb__CC-MAIN-2021-31__0__85698265", "lang": "en", "text": "Views:0 Author:Site Editor Publish Time: 2021-01-18 Origin:Site\nIn view of the fact that feed additives have integrated multiple disciplines and multiple new technologies, both resources, types, functions and application scopes have been further expanded. As the first restriction, feed grade L lysine hydrochloride has attracted much attention in this field. In any case, in order to feed the growing population, L lysine hydrochloride will have more applications in the future.\nHow about the current performance of L lysine hydrochloride?\nHow to adjust dosage of L lysine hydrochloride in the formula?\nDoes domestic L lysine hydrochloride have a hopeful prospect?\nWhat are requirements for starting L lysine hydrochloride business?\nAnimals gain weight by ingesting food, and for livestock kept on farms, the protein they get is mainly from feed. The lack of feed ingredients, especially the lack of protein feed is the primary factor restricting the leap increase of animal products.\nThe introduction of feed grade L lysine hydrochloride opens up protein resources other than conventional protein, and opens up a way to solve the contradiction between the development of animal husbandry and the lack of protein feed.\nL lysine hydrochloride produced by the feed additive industry can easily increase the concentration of essential amino acids in the feed, which not only improves the nutritional value of the feed, but also has many other beneficial effects, such as reducing the farmer’s formula bill. This makes feed grade L lysine hydrochloride widely used in the feed industry.\nWhen each farm actually designs the feed additives formula, it is necessary to flexibly adjust the amount of L lysine hydrochloride used according to the different species of animals, different stages and different feed material varieties, in order to obtain better feeding benefits.\nThe methods of raising livestock are different, and the feed using L lysine hydrochloride is safe and affordable. It can not only balance the nutrition, but also meet the fine texture requirements of the feed and have good palatability.\nAll kinds of livestock and poultry can use L lysine hydrochloride and methionine, but the use of methionine is emphasized in poultry feed, while pig breeding pays more attention to the use of L lysine hydrochloride.\nThe rational use of both is more important. The amount of use varies according to the raw materials and nutrient content of each region.\nIn the case of pig feed, the amount of L lysine hydrochloride used is generally more than that of methionine.\nThe sufficient methionine rather than L lysine hydrochloride must be added to the feed for broilers and layers.\nIf rapeseed cake or cotton seed cake is used to replace soybean meal, the amount of lysine added must be increased appropriately.\nIf fish meal is used to replace soybean meal, the amount of lysine added can be appropriately reduced.\nThe domestic L lysine hydrochloride market started relatively late, but with the rapid economic development and the continuous improvement of related technologies, it is showing a trend of rapid development.\nAt this stage, China has gradually developed into the world's largest producer of lysine. In 2018, lysine production capacity accounted for more than 70% of the global market. It shows that my country's feed grade L lysine hydrochloride is becoming more and more influential in the international market.\nL lysine hydrochloride has a wide range of applications. Among them, the feed industry has the largest consumer demand for L lysine hydrochloride, accounting for more than 90% of the entire downstream demand market. Overall, the production and production capacity of feed grade L lysine hydrochloride showed a dual growth trend, indicating that the market development continued to improve.\nAlthough the market prospects for L lysine hydrochloride are relatively broad, it is not so easy to operate L lysine hydrochloride business. The following are the most basic requirements for starting a L lysine hydrochloride business.\nThe operator shall obtain the L lysine hydrochloride business license issued by the relevant department, and the business content shall cover feed additives.\nL lysine hydrochloride producers must be familiar with the laws and regulations of the feed industry and have a certain understanding of the basic regulations of the industry, and the products they operate must comply with the requirements of the laws and regulations.\nAfter all, feed additives have storage requirements such as temperature and humidity control. Feed additives producers also need to have business premises and storage facilities that are compatible with feed additives. The waste of L lysine hydrochloride caused by improper preservation every year is considerable. This is what every L lysine hydrochloride operator should be wary of.\nIt is precisely because many feed additives producers fail to meet the three most basic requirements that the feed grade L lysine hydrochloride market has both standard and inferior products intermingled. However, if you choose Polifar Group. There will be no such concerns. The feed grade L lysine hydrochloride we produce is sold all over the world, and our integrity, strength and product quality have been unanimously recognized by the industry.\nHead Office: Room 1506, Building B-1, Greenland Window Business Plaza, No. 2 Jinlan Road, Jiangning District, Nanjing\nGuangzhou Branch Office: Room 5303A, 3rd Floor, DongGuan Building ,No.620, XingNan Avenue, NanCun Town, PanYu District, GuangZhou City, GuangDong Province, China", "domain": "chemistry", "round": 3} +{"url": "https://www.hindawi.com/journals/bmri/2013/180156/ref/", "date": "2017-03-26T17:12:09Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-13/segments/1490218189244.95/warc/CC-MAIN-20170322212949-00362-ip-10-233-31-227.ec2.internal.warc.gz", "language_score": 0.7405708432197571, "token_count": 2534, "dump": "CC-MAIN-2017-13", "global_id": "webtext-fineweb__CC-MAIN-2017-13__0__202168318", "lang": "en", "text": "- About this Journal ·\n- Abstracting and Indexing ·\n- Aims and Scope ·\n- Annual Issues ·\n- Article Processing Charges ·\n- Articles in Press ·\n- Author Guidelines ·\n- Bibliographic Information ·\n- Citations to this Journal ·\n- Contact Information ·\n- Editorial Board ·\n- Editorial Workflow ·\n- Free eTOC Alerts ·\n- Publication Ethics ·\n- Reviewers Acknowledgment ·\n- Submit a Manuscript ·\n- Subscription Information ·\n- Table of Contents\nBioMed Research International\nVolume 2013 (2013), Article ID 180156, 4 pages\nBioremediation of Direct Blue 14 and Extracellular Ligninolytic Enzyme Production by White Rot Fungi: Pleurotus Spp.\nDepartment of Biotechnology, VBS Purvanchal University, Jaunpur, UP 222001, India\nReceived 13 April 2013; Accepted 26 May 2013\nAcademic Editor: Nikhat J. Siddiqi\nCopyright © 2013 M. P. Singh et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.\n- G. M. B. Soares, M. Costa-Ferreira, and M. T. Pessoa de Amorim, “Decolorization of an anthraquinone-type dye using a laccase formulation,” Bioresource Technology, vol. 79, no. 2, pp. 171–177, 2001.\n- Y. Wong and J. Yu, “Laccase-catalyzed decolorization of synthetic dyes,” Water Research, vol. 33, no. 16, pp. 3512–3520, 1999.\n- H. M. Pinheiro, E. Touraud, and O. Thomas, “Aromatic amines from azo dye reduction: status review with emphasis on direct UV spectrophotometric detection in textile industry wastewaters,” Dyes and Pigments, vol. 61, no. 2, pp. 121–139, 2004.\n- E. Forgacs, T. Cserháti, and G. Oros, “Removal of synthetic dyes from wastewaters: a review,” Environment International, vol. 30, no. 7, pp. 953–971, 2004.\n- E. P. Chagas and L. R. Durrant, “Decolorization of azo dyes by Phanerochaete chrysosporium and Pleurotus sajorcaju,” Enzyme and Microbial Technology, vol. 29, no. 8-9, pp. 473–477, 2001.\n- K. Murugesan, I.-H. Nam, Y.-M. Kim, and Y.-S. Chang, “Decolorization of reactive dyes by a thermostable laccase produced by Ganoderma lucidum in solid state culture,” Enzyme and Microbial Technology, vol. 40, no. 7, pp. 1662–1672, 2007.\n- Z. Zheng and J. P. Obbard, “Oxidation of polycyclic aromatic hydrocarbons (PAH) by the white rot fungus, Phanerochaete chrysosporium,” Enzyme and Microbial Technology, vol. 31, no. 1-2, pp. 3–9, 2002.\n- M. Chivukula and V. Renganathan, “Phenolic azo dye oxidation by laccase from Pyricularia oryzae,” Applied and Environmental Microbiology, vol. 61, no. 12, pp. 4374–4377, 1995.\n- C. O'Neill, A. Lopez, S. Esteves, F. R. Hawkes, D. L. Hawkes, and S. Wilcox, “Azo-dye degradation in an anaerobic-aerobic treatment system operating on simulated textile effluent,” Applied Microbiology and Biotechnology, vol. 53, no. 2, pp. 249–254, 2000.\n- K. Fahr, H.-G. Wetzstein, R. Grey, and D. Schlosser, “Degradation of 2,4-dichlorophenol and pentachlorophenol by two brown rot fungi,” FEMS Microbiology Letters, vol. 175, no. 1, pp. 127–132, 1999.\n- V. S. Ferreira-Leitão, M. E. A. de Carvalho, and E. P. S. Bon, “Lignin peroxidase efficiency for methylene blue decolouration: comparison to reported methods,” Dyes and Pigments, vol. 74, no. 1, pp. 230–236, 2007.\n- V. K. Pandey, M. P. Singh, A. K. Srivastava, S. K. Vishwakarma, and S. Takshak, “Biodegradation of sugarcane bagasse by white rot fungus Pleurotus citrinopileatus,” Cellular and Molecular Biology, vol. 58, no. 1, pp. 8–14, 2012.\n- M. P. Singh, V. K. Pandey, A. K. Srivastava, and S. K. Viswakarma, “Biodegradation of Brassica haulms by white rot fungus Pleurotus eryngii,” Cellular and Molecular Biology, vol. 57, no. 1, pp. 47–55, 2011.\n- S. K. Vishwakarma, M. P. Singh, A. K. Srivastava, and V. K. Pandey, “Azo dye (direct blue) decolorization by immobilized extracellular enzymes of Pleurotus species,” Cellular and Molecular Biology, vol. 58, no. 1, pp. 21–25, 2012.\n- K. Svobodová, A. Majcherczyk, Č. Novotný, and U. Kües, “Implication of mycelium-associated laccase from Irpex lacteus in the decolorization of synthetic dyes,” Bioresource Technology, vol. 99, no. 3, pp. 463–471, 2008.\n- M. S. Revankar and S. S. Lele, “Synthetic dye decolorization by white rot fungus, Ganoderma sp. WR-1,” Bioresource Technology, vol. 98, no. 4, pp. 775–780, 2007.\n- C. Riccardi, M. Papacchini, A. Mansi et al., “Characterization of bacterial population coming from a soil contaminated by polycyclic aromatic hydrocarbons (PAHs) able to degrade pyrene in slurry phase,” Annals of Microbiology, vol. 55, no. 2, pp. 85–90, 2005.\n- R. P. S. Dhaliwal, H. S. Garcha, and P. K. Khanna, “Regulation of lignocellulotic enzyme system in Pleurotus ostreatus,” Indian Journal of Microbiology, vol. 31, no. 2, pp. 181–184, 1991.\n- J. Putter, “Peroxidases,” in Methods of Enzymatic Analysis, H. U. Bergmeyer, Ed., vol. 2, pp. 685–690, Academic Press, NewYork, NY, USA, 1974.\n- M. C. Abrahão, A. De Mello Gugliotta, R. Da Silva, R. J. Y. Fujieda, M. Boscolo, and E. Gomes, “Ligninolytic activity from newly isolated basidiomycete strains and effect of these enzymes on the azo dye orange II decolourisation,” Annals of Microbiology, vol. 58, no. 3, pp. 427–432, 2008.\n- R. Neelamegam, V. Baskaran, R. Dhanasekar, and T. Viruthagiri, “Decolourization of synthetic dyes using rice straw attached Pleurotus ostreatus,” Indian Journal of Chemical Technology, vol. 11, no. 5, pp. 622–625, 2004.\n- M. A. Pickard, H. Vandertol, R. Roman, and R. Vazquez-Duhalt, “High production of ligninolytic enzymes from white rot fungi in cereal bran liquid medium,” Canadian Journal of Microbiology, vol. 45, no. 7, pp. 627–631, 1999.\n- M. P. Singh, A. K. Pandey, S. K. Vishwakarma, A. K. Srivastava, and V. K. Pandey, “Extracellular Xylanase Production by Pleurotus species on Lignocellulosic Wastes under in vivo Condition using Novel Pretreatment,” Cellular and Molecular Biology, vol. 58, no. 1, pp. 170–173, 2012.\n- M. P. Singh, V. K. Pandey, A. K. Pandey, A. K. Srivastava, N. K. Vishwakarma, and V. K. Singh, “Production of xylanase by white rot fungi on wheat straw,” Asian Journal of Microbiology, Biotechnology and Environmental Sciences, vol. 10, no. 4, pp. 859–862, 2008.\n- T. Tsukihara, Y. Honda, R. Sakai, T. Watanabe, and T. Watanabe, “Mechanism for oxidation of high-molecular-weight substrates by a fungal versatile peroxidase, MnP2+,” Applied and Environmental Microbiology, vol. 74, no. 9, pp. 2873–2881, 2008.\n- M. Hofrichter, “Review: lignin conversion by manganese peroxidase (MnP),” Enzyme and Microbial Technology, vol. 30, no. 4, pp. 454–466, 2002.\n- M. L. Rabinovich, A. V. Bolobova, and L. G. Vasil'chenko, “Fungal decomposition of natural aromatic structures and xenobiotics: a review,” Applied Biochemistry and Microbiology, vol. 40, no. 1, pp. 1–17, 2004.\n- U. Meyer, “Biodegradation of synthetic organic colorants,” FEMS Symposium, vol. 12, pp. 371–385, 1981.\n- T. Suzuki, S. Timofei, L. Kurunczi, U. Dietze, and G. Schüürmann, “Correlation of aerobic biodegradability of sulfonated azo dyes with the chemical structure,” Chemosphere, vol. 45, no. 1, pp. 1–9, 2001.\n- A. Zille, T. Tzanov, G. M. Gübitz, and A. Cavaco-Paulo, “Immobilized laccase for decolourization of reactive Black 5 dyeing effluent,” Biotechnology Letters, vol. 25, no. 17, pp. 1473–1477, 2003.", "domain": "chemistry", "round": 3} +{"url": "https://www.findaphd.com/search/projectdetails.aspx?PJID=63308", "date": "2017-10-22T17:35:02Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-43/segments/1508187825399.73/warc/CC-MAIN-20171022165927-20171022185927-00084.warc.gz", "language_score": 0.9261785745620728, "token_count": 702, "dump": "CC-MAIN-2017-43", "global_id": "webtext-fineweb__CC-MAIN-2017-43__0__1685877", "lang": "en", "text": "The candidate should have a first class or upper second class honours degree, or a master’s degree (or equivalent qualification), in Chemistry. Previous experience in Organic Synthesis is desirable. Evidence of good spoken and written English is essential. The candidate should have an IELTS score of 6.5 or above, or an equivalent qualification, if the first language is not English. This position is open to all qualified candidates irrespective of nationality.\nThe student will be awarded a PhD degree from the University of Liverpool (UK) upon successful completion of the program.\nPhosphinic peptides have been widely used for the study of proteases so as to elucidate their function in health and disease. They act as reversible, non-toxic, potent and selective inhibitors of proteases. Phosphinic peptides have been mostly used as metalloprotease inhibitors, although phosphinic inhibitors of aspartic acid proteases and other classes of enzymes such as ligases and kinases have also been reported. Some of the most interesting targets are Angiotensin Converting Enzyme (ACE) and Matrix Metalloproteases (MMPs). Nevertheless, the use of phosphinic acids as drugs presents a challenge with respect to their drug delivery. At physiological pH, phosphinic acids are negatively charged and due to their polarity are unable to penetrate cell membranes. To overcome this problem, esters have been used as prodrugs. These esters should meet several requirements, such as chemical stability and solubility of the prodrug in the gastrointestinal tract, good permeability across cell membranes, and finally efficient release of the drug at the target. Though several kinds of such phosphinate esters have been developed, and have been used in clinical trials, or are already in the market, sugar-based esters have never been used so far for phosphinic acids. It is anticipated that such an approach would be quite effective, since sugars have been used successfully before as pro-drug candidates, due to their hydrophilic properties. The aim of this project is to develop phosphinic peptide and non-peptide structures that show activity towards important enzyme targets, such as ACE (hypertension), MMPs (cancer), HIV proteases (AIDS), and Plasmepsins (malaria). The plan is to convert these phosphinic acids to esters using sugars and study the cell permeability and efficacy (antimalarial and antiviral properties) and whole animal disposition of both parent-drugs and their pro-drugs systems.\nFor more information about doctoral scholarship and PhD programme at Xi’an Jiaotong-Liverpool University (XJTLU): Please visit\nHow to Apply:\nInterested applicants are advised to email the following documents to [email protected]\n(please put the project title and primary supervisor’s name in the subject line).\n- Two reference letters\n- Personal statement outlining your interest in the position\n- Proof of English language proficiency (an IELTS score of above 6.5 or equivalent is required\n- Verified school transcripts in both Chinese and English (for international students, only the English version is required)\n- Verified certificates of education qualifications in both Chinese and English (for international students, only the English version is required)\nInformal enquiries may be addressed to Dr. Magdalini Matziari ([email protected]\n), whose personal profile is linked below;", "domain": "chemistry", "round": 3} +{"url": "https://thorax.bmj.com/content/58/2/127.abstract", "date": "2020-07-10T23:38:25Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-29/segments/1593655912255.54/warc/CC-MAIN-20200710210528-20200711000528-00464.warc.gz", "language_score": 0.9439627528190613, "token_count": 515, "dump": "CC-MAIN-2020-29", "global_id": "webtext-fineweb__CC-MAIN-2020-29__0__10051722", "lang": "en", "text": "Background: Surfactant synthesis and secretion has been shown to be impaired in type II cells from diseased lungs. The mechanism of surfactant lipid recycling, which is an important physiological process in surfactant treatment, was studied in type II cells isolated from injured lungs.\nMethods: Different stages of lung injury were induced by exposing rats to 10 ppm nitrogen dioxide (NO2) for 3, 20, and 28 days. Type II cells were isolated from these lungs and recycling of 3H-DPPC labelled surfactant-like liposomes was studied in vitro.\nResults: Uptake of liposomes (150 μg/ml) for 20 minutes in the absence and presence of surfactant protein-A (SP-A, 5 μg/ml) was higher in cells from NO2 injured lungs (63–78%) than in control cells. There was no difference in liposome uptake between the groups with NO2 exposure of different duration. After liposome uptake, most of the internalised label remained in the phosphatidylcholine (PC) fraction and increased with duration of exposure to NO2. After 20 minutes internalisation, cells were allowed to resecrete lipids for a further 20 minute period. In cells from controls and from all stages of lung injury, liposomes that had been internalised in the presence of SP-A were resecreted to a greater extent than those internalised without SP-A. However, cells from lungs exposed to NO2 resecreted less lipid than cells from control lungs. Again, there was no difference in resecretion between the groups with NO2 exposure of different duration.\nConclusion: Type II cells from injured lungs internalise more surfactant-like liposomes than cells from controls, suggesting a putative therapeutic significance to cope with limited alveolar surfactant pools in lung injury.\n- surfactant system\n- nitrogen dioxide\n- type II pneumocytes\n- bronchoalveolar lavage\n- surfactant-like liposomes\nStatistics from Altmetric.com\nThe study was supported by the BMBF Grant No. 01GC6901/5, Clinical Research group “Chronic Lung Injury”.\nIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.", "domain": "chemistry", "round": 3} +{"url": "http://www.labome.org/locale/experts-and-doctors-on-phospholipase-d-in-united-kingdom-1563761.html", "date": "2020-11-23T19:58:25Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-50/segments/1606141164142.1/warc/CC-MAIN-20201123182720-20201123212720-00244.warc.gz", "language_score": 0.8062337040901184, "token_count": 1085, "dump": "CC-MAIN-2020-50", "global_id": "webtext-fineweb__CC-MAIN-2020-50__0__55345361", "lang": "en", "text": "Experts and Doctors on phospholipase d in United Kingdom\nLocale: United Kingdom\nTopic: phospholipase d\nPonting C, Kerr I. A novel family of phospholipase D homologues that includes phospholipid synthases and putative endonucleases: identification of duplicated repeats and potential active site residues. Protein Sci. 1996;5:914-22 pubmed\n..It is suggested that, for each of these enzymes, conserved histidine, lysine, aspartic acid, and/or asparagine residues may be involved in a two-step ping pong mechanism involving an enzyme-substrate intermediate. ..\nBen Smith A, Dove S, Martin A, Wakelam M, Savage C. Antineutrophil cytoplasm autoantibodies from patients with systemic vasculitis activate neutrophils through distinct signaling cascades: comparison with conventional Fcgamma receptor ligation. Blood. 2001;98:1448-55 pubmed\n..These results demonstrate that though ligation of FcgammaRIIa and FcgammaRIIIb may be necessary, it is likely that ANCAs require other membrane cofactors for neutrophil activation. ..\nAlderton F, Darroch P, Sambi B, McKie A, Ahmed I, Pyne N, et al\n. G-protein-coupled receptor stimulation of the p42/p44 mitogen-activated protein kinase pathway is attenuated by lipid phosphate phosphatases 1, 1a, and 2 in human embryonic kidney 293 cells. J Biol Chem. 2001;276:13452-60 pubmed\n..Therefore, these findings show that the lipid phosphate phosphatases 1, 1a, and 2 may function to perturb G-protein-coupled receptor signaling per se rather than limiting bioavailability of lipid agonists at their respective receptors. ..\nSkippen A, Jones D, Morgan C, Li M, Cockcroft S. Mechanism of ADP ribosylation factor-stimulated phosphatidylinositol 4,5-bisphosphate synthesis in HL60 cells. J Biol Chem. 2002;277:5823-31 pubmed\n..We therefore conclude that both PA derived from the PLD pathway and ARF proteins, by directly activating PIP 5-kinase, contribute to the regulation of PI(4,5)P(2) synthesis at the plasma membrane in HL60 cells. ..\nBenítez Rajal J, Lorite M, Burt A, Day C, Thompson M. Phospholipase D and extracellular signal-regulated kinase in hepatic stellate cells: effects of platelet-derived growth factor and extracellular nucleotides. Am J Physiol Gastrointest Liver Physiol. 2006;291:G977-86 pubmed\n..Instead, these responses may be linked to other phenotypic changes associated with activated HSC such as increases in contraction, motility, or extracellular matrix deposition. ..\nHughes W, Larijani B, Parker P. Detecting protein-phospholipid interactions. Epidermal growth factor-induced activation of phospholipase D1b in situ. J Biol Chem. 2002;277:22974-9 pubmed\n..Application of this approach will facilitate the spatial resolution of many protein-phospholipid interactions that are key events in the regulation of cellular processes. ..\nO Luanaigh N, Pardo R, Fensome A, Allen Baume V, Jones D, Holt M, et al\n. Continual production of phosphatidic acid by phospholipase D is essential for antigen-stimulated membrane ruffling in cultured mast cells. Mol Biol Cell. 2002;13:3730-46 pubmed\n..We conclude that both activation of ARF6 by antigen and a continual PLD2 activity are essential for local phosphatidylinositol(4,5)bisphosphate generation that regulates dynamic actin cytoskeletal rearrangements. ..\nMitchell R, Robertson D, Holland P, Collins D, Lutz E, Johnson M. ADP-ribosylation factor-dependent phospholipase D activation by the M3 muscarinic receptor. J Biol Chem. 2003;278:33818-30 pubmed\n..Examples of other G protein-coupled receptors assessed in comparison display alternative pathways of protein kinase C- or ARF6-dependent activation of PLD2. ..\nDelon C, Manifava M, Wood E, Thompson D, Krugmann S, Pyne S, et al\n. Sphingosine kinase 1 is an intracellular effector of phosphatidic acid. J Biol Chem. 2004;279:44763-74 pubmed\n..The SK1-PA interaction maps to the C terminus of SK1 and is independent of catalytic activity or of the diacylglycerol kinase-like domain of the enzyme. Thus SK1 constitutes a novel, physiologically relevant PA effector. ..", "domain": "chemistry", "round": 3} +{"url": "https://www.atlantis-press.com/proceedings/bth-hsic-19/125941103", "date": "2023-05-27T23:24:59Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-23/segments/1685224643388.45/warc/CC-MAIN-20230527223515-20230528013515-00453.warc.gz", "language_score": 0.8670632839202881, "token_count": 551, "dump": "CC-MAIN-2023-23", "global_id": "webtext-fineweb__CC-MAIN-2023-23__0__149766229", "lang": "en", "text": "Antifertility Effect of N-hexane, Ethyl Acetate and Water Fractions from Carica papaya Leaves on Sperm Motility in Male Wistar Rats\n- 10.2991/ahsr.k.200523.038How to use a DOI?\n- antifertility, Carica papaya, sperm motility, N-hexane, ethyl acetate, water fraction\nObjective: The aim of this study was to investigate the antifertility effect of N-hexane, ethyl acetate, and water fractions from C. papaya leaves on sperm motility in male Wistar rats. Method: Twenty four rats used in this study. Rats were devided into 4 groups: normal group and Carica papaya fraction group (N-hexane; ethyl acetate; and water). Rats were given Carica papaya fractions at dose 0.4 g/ Kg BW rat/day for 20 days). Carica papaya leaves were extracted by ethanol and did fractionation by liquid-liquid methods. Results and Discussion: The results of this study were N-hexane, ethyl acetate and water fractions significantly (P<0.05) produced decreased in sperm motility compered with normal group. The decresed Carica papaya fractions (N-hexane, ethyl acetate and water) were 33 %, 65%, and 75% respectively. Conclusion: Carica papaya fractions (N-hexane, ethyl acetate and water) have antifertility effect on sperm motility.\n- © 2020, the Authors. Published by Atlantis Press.\n- Open Access\n- This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).\nCite this article\nTY - CONF AU - Nur Laili Dwi Hidayati PY - 2020 DA - 2020/06/08 TI - Antifertility Effect of N-hexane, Ethyl Acetate and Water Fractions from Carica papaya Leaves on Sperm Motility in Male Wistar Rats BT - The proceedings of the 2nd Bakti Tunas Husada-Health Science International Conference (BTH-HSIC 2019) PB - Atlantis Press SP - 155 EP - 158 SN - 2468-5739 UR - https://doi.org/10.2991/ahsr.k.200523.038 DO - 10.2991/ahsr.k.200523.038 ID - Hidayati2020 ER -", "domain": "chemistry", "round": 3} +{"url": "https://www.clearsynth.com/en/CSP01742.html", "date": "2018-05-24T03:50:38Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-22/segments/1526794865913.52/warc/CC-MAIN-20180524033910-20180524053910-00549.warc.gz", "language_score": 0.7666036486625671, "token_count": 252, "dump": "CC-MAIN-2018-22", "global_id": "webtext-fineweb__CC-MAIN-2018-22__0__23239788", "lang": "en", "text": "We speak your languagePlease select your preferred languageClearsynth language translation\nVicagrel Carboxylic AcidPrint | Download PDF\nBasic Chemical Information\nAVAILABLE ENQUIRE NOW\nDo you want a quotation or have a question about 'Vicagrel Carboxylic Acid' ? We normally respond within 2 hours.\n(Available within 1-2 Weeks)Product maybe under re-certification or re-stock. Enquire now to know exact date of delivery and pricing.\nPage info:This page contains information about Vicagrel Carboxylic Acid Cas NA and its Impurities.\nVicagrel Carboxylic Acid Vicagrel Carboxylic Acid Worldwide Suppliers of Vicagrel Carboxylic Acid https://www.clearsynth.com/en/CSP01742.html Impurities Clearsynth NA\nRecently Viewed Products\nKeywords for Vicagrel Carboxylic Acid: Vicagrel Carboxylic Acid,CAS=NA,Impurities of Vicagrel,Vicagrel Impurities,Molecular formula=C17H16ClNO4S,analytical standards of Vicagrel", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/timp1-antibody-epr16616-207-ab222679.html", "date": "2020-08-11T08:00:36Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-34/segments/1596439738735.44/warc/CC-MAIN-20200811055449-20200811085449-00048.warc.gz", "language_score": 0.7328001856803894, "token_count": 655, "dump": "CC-MAIN-2020-34", "global_id": "webtext-fineweb__CC-MAIN-2020-34__0__165334456", "lang": "en", "text": "Key features and details\n- Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply\n- Rabbit monoclonal [EPR16616-207] to TIMP1\n- Suitable for: Sandwich ELISA\n- Reacts with: Mouse\nProduct nameAnti-TIMP1 antibody [EPR16616-207]\nSee all TIMP1 primary antibodies\nDescriptionRabbit monoclonal [EPR16616-207] to TIMP1\nTested applicationsSuitable for: Sandwich ELISAmore details\nSpecies reactivityReacts with: Mouse\nThe details of the immunogen for this antibody are not available.\nStorage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.\nStorage bufferPreservative: 0.02% Sodium azide\nConcentration information loading...\nPurityProtein A purified\nOur Abpromise guarantee covers the use of ab222679 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\n|Sandwich ELISA||Use at an assay dependent concentration.|\nFunctionComplexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Also mediates erythropoiesis in vitro; but, unlike IL-3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13 and MMP-16. Does not act on MMP-14.\nSequence similaritiesBelongs to the protease inhibitor I35 (TIMP) family.\nContains 1 NTR domain.\nmodificationsThe activity of TIMP1 is dependent on the presence of disulfide bonds.\n- Information by UniProt\n- Clgi antibody\n- Collagenase inhibitor antibody\n- Collagenase inhibitor, Human antibody\nExample of mouse TIMP1 standard curve in 1X Cell Extraction Buffer PTR using recombinant TIMP1 RabMAb antibody (ab222679) and a recombinant monoclonal antibody. Background-subtracted values (mean +/- SD) are graphed.\nFor a matched antibody pair set, see Mouse TIMP1 Matched Antibody Pair Kit (ab221435).\nFor a complete ELISA kit, see Mouse TIMP1 ELISA kit (ab196265).\nTo our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.\nab222679 has not yet been referenced specifically in any publications.", "domain": "chemistry", "round": 3} +{"url": "http://www.kifpool.com/books/advances-in-catalysis", "date": "2018-12-15T09:39:36Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-51/segments/1544376826842.56/warc/CC-MAIN-20181215083318-20181215105318-00532.warc.gz", "language_score": 0.6929150819778442, "token_count": 1533, "dump": "CC-MAIN-2018-51", "global_id": "webtext-fineweb__CC-MAIN-2018-51__0__76918301", "lang": "en", "text": "By W G Frankenburg; V I Komarewsky; Eric K Rideal\nADVANCES IN CATALYSIS quantity 3.\ncontent material: entrance hide; Advances in Catalysis and comparable topics, quantity III; Copyright web page; Contents; members to quantity III; Editors' Preface; bankruptcy 1. Balandin's Contribution to Heterogeneous Catalysis; I. advent; II. The Multiplet concept; III. dialogue of the idea; IV. Steric concerns in Catalysis; References; bankruptcy 2. Magnetism and the constitution of Catalytically lively Solids; I. creation; II. basic rules; III. Experimental tools; IV. The Susceptibility Isotherm; V. Supported Chromium Oxide; VI. Supported Oxides of Manganese; VII. Supported Nickel Oxide VIII. Supported Iron OxideIX. Supported Copper Oxide; X. similar structures; XI. Self-Supported platforms; XII. Ferromagnetism; XIII. identity of Ferromagnetic stages; XIV. response strategies; XV. answer procedures; XVI. precis; References; bankruptcy three. Catalytic Oxidation of Acetylene in Air for Oxygen Manufacture; I. advent; II. of Air and Acetylene; III. Acetylene removing; IV. Catalyst Compositions; V. Regeneration; VI. Mechanism of the Oxidation Reactions; VII. Mechanism of the Oxidation by way of Silver Nitrate; References; bankruptcy four. The Poisoning of metal Catalysts I. Catalysts at risk of PoisoningII. primary sorts of Catalyst Poisons; III. the shape of Catalyst Poisoning Curves; IV. extra components Influencing Toxicity; V. priceless Poisoning; References; bankruptcy five. Catalytic Cracking of natural Hydrocarbons; I. advent; II. Catalytic Cracking Reactions; III. Catalytic Cracking of Paraffins; IV. Catalytic Cracking of Olefins; V. Catalytic Cracking of Naphthenes; VI. Catalytic Cracking of fragrant Hydrocarbons; VII. constitution of Cracking Catalysts; References; bankruptcy 6. Chemical features and constitution of Cracking Catalysts I. IntroductionII. dimension of the \"Acidity\" of Cracking Catalysts; III. id of the Acid facilities because the Catalytically energetic websites; IV. constitution of the Acid; V. Mechanism of Hydrocarbon Reactions on a Cracking Catalyst; References; bankruptcy 7. response premiums and Selectivity in Catalyst Pores; I. advent; III . The actual photo of the Pore constitution; III. Mechanism of delivery in Catalyst Pores; IV. actual elements picking response charges on Porous Catalysts . (Definition of cost Constants, the elemental Differential Equation and the legislation of Conservation of Mass V. response charges in unmarried PoresVI. response premiums on functional Catalyst Pellets; VII. response charges on Poisoned Catalysts (Apparent Selective Poisoning); VIII. impression of Pore constitution on Catalyst Selectivity; Appendix; thesaurus of Symbols; References; bankruptcy eight. Nickel Sulfide Catalysts; I. advent; II. The Nickel-Sulfur Equilibrium; III. actual Adsorption of Gases on Ni2S2 Catalysts; IV. Chemisorption of Gases on Ni2S2; V. helps for Stabilizing Nickel Sulfide; VI. education of Nickel Sulfide Catalysts; VII. valuable lifestyles and Regeneration\nsummary: ADVANCES IN CATALYSIS quantity three\nRead Online or Download Advances in catalysis PDF\nBest industrial & technical books\nIn latest global of more and more stringent environmental rules, it's severe to spot and effectively handle environmental concerns within the ceramic to make sure luck. additionally, ceramics and glasses play a serious function within the nuclear undefined. Nuclear fuels and waste kinds for low-level and high-level radioactive, combined, and dangerous wastes are essentially both ceramic of glass.\nAs power calls for proceed to surge world wide, the necessity for effective and environmentally impartial strength construction turns into more and more obvious. In its first variation, this publication provided a well-rounded viewpoint at the improvement of bio-based feedstocks, biodegradable plastics, hydrogen power, gas cells, and different facets regarding renewable assets and sustainable strength construction.\n- Fire and Polymers IV. Materials and Concepts for Hazard Prevention\n- Practical Guide to Adhesive Bonding of Small Engineering Plastic and Rubber Parts\n- Process Equipment Procurement in the Chemical and Related Industries\n- Introduction to Industrial Polyethylene: Properties, Catalysts, and Processes\nExtra resources for Advances in catalysis\nProc. Roy. (London)AllO, 283 (1926). Ipatieff, V. , Corson, B. , and Kurbatov, J. , J. Phys. Chem. 43,589 (1939). Corson, B. , and Ipatieff, V. , J. Phys. Chem. 46, 431 (1941). Kraus, E. , and Hunt, W. , Mineralogy. McGraw-Hill, New York, 1928. Dilke, M. , Eley, D. , and Maxted, E. , Nature 161, 804 (1948). Dowden, D. , Research 1, 239 (1948). Dowden, D. , Chemistry & Industry 1949, 320. Eley, D. , Chemistry & Industry 1949,320. 33. Mott, N. , The Properties of Metals and Alloys. Oxford University Press, London, 1936.\nVIII. Supported Iron Oxide.. . . . . . . . . . . . . . . . . . . . . . . 1. Preparation.. . . . . ............................ 2. Susceptibility Data.. . IX. Supported Copper Oxide.. 1. Preparation.. 2. Susceptibility Data. ............................ 3. Activity Data . . . . . . . . . . . . . . . . . . . . . . . . . X. Related Systems . . . . . . . . . . . . . .\n71,2522 (1949). 35. Roberts, J. , Proc. Roy. (London) A162, 445 (1935). 36. Roberts, J. , Some Problems in Adsorption. Cambridge University Press, London, 1939. 37. , Smith, A. , Proc. Roy. (London)A177,62 (1940). 38. Trapnell, B. M. , unpublished experiments. 39. Rideal, E. , Proc. Cambridge Phil. Soc. 36, 130 (1939). 40. , Chemistry & Industry 62, 335 (1943). 41. Eley, D. , Advances in Catalysis, Vol. I. , New York, 1948. 42. , Benedict, W. , and Taylor, H. , J. Am. Chem. 68, 1445, 1795 (1936).\nAdvances in catalysis by W G Frankenburg; V I Komarewsky; Eric K Rideal\nCategories: Industrial Technical", "domain": "chemistry", "round": 3} +{"url": "http://zjff.7rlogistics.ru/91428277", "date": "2021-12-01T18:08:01Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-49/segments/1637964360881.12/warc/CC-MAIN-20211201173718-20211201203718-00409.warc.gz", "language_score": 0.8739433884620667, "token_count": 2428, "dump": "CC-MAIN-2021-49", "global_id": "webtext-fineweb__CC-MAIN-2021-49__0__160913700", "lang": "en", "text": "How to Choose the Right Transmission Fluid. This product is great. 5L) Rear axle friction modifier. 7 qts DCT Check out our Drivetrain Components here: S550 Mustang Drivetrain Components S550 Mustang Rear End Fluid Capacity: 2. Manual Transmission fluids use a different Friction Modifier for synchro engagement, a modifier that is NOT the same Friction Modifier manual transmission fluid with 5 friction modifier chemistry as used in differential lubes, engine oils, or hydraulic fluids. Other than the fact that my transmission was long overdue (its a LSD T2T4 transmission for a Honda) for a fluid change, using this fluid helped a 2nd gear grind and just lack of smoothness in the shifting. Lucas Oil is a well-known brand that needs no introduction and its transmission fluid additive is an excellent choice for both manual and automatic transmissions.\nTherefore, the automatic transmission fluid, as well as additives, are on a different level than manual gearbox fluid. Information is provide for most vehicles. These additives reduce rough shifting and friction while eliminating slip, controlling temperature and repairing shudder, chatter and whining. While doing a rebuild, or while doing timely maintenance we always recommending changing out your factory fluid with full Synthetic ATF and a bottle of Friction Modifier for substantially improved shift feel. I went to this quick lube place, they did a transmission fluid flush and put in Dexron III. Manual Transmission Friction Modifier Fluid; Synchromax is a synthetic manual transmission fluid designed to increase performance and expand the life of your manual transmission. L4 engine: Manual Transmission Fluid with 5% Friction modifier (GM P/N. 88 L) Engine coolant with Track Pack (If equipped).\n. 4 L) Brake fluid. L4 engine: Manual Transmission Fluid with 5% Friction modifier (GM P/N. challenger friction modifier, dodge challenged tremec transmission fluid, dodge challenger rt fluids and capacities, challenger manual fluid capacity, 391 dodge getrag rear oil capacity, 72 charger differential fluid capacity, challenger tremec fluid volume, dodge challanger manual transmission fluid capacity,. \"Lube\" is for vintage models and \"Fluid\" is for newer cars (late-1990s and newer). Conversely, in an automatic transmission, one fluid is manual transmission fluid with 5 friction modifier used to provide lubrication, hydraulic power transfer and many other functions. This item: Genuine GM FluidSynchromesh Friction Modified Manual Transmission Fluid - 32 oz. If you have a limited slip, add the friction modifier if using regular oil.\nIt is also ideal for transfer cases and 2-cycle motorcycle gear boxes that specify light-viscosity lubricants. The oil is designed to reduce friction and provide necessary cooling. Some of the aftermarket ATF (automatic transmission fluid) that is labeled as compatible with Mopar&39;s ATF+4 may have additional friction modifiers in the fluid package. It is non-corrosive to yellow metals, and its outstanding anti-wear properties protect gears and bearings under severe duty. Same thing with some of the gear oils and MTF (manual transmission fluid). (1 L) of ATF for the total capacity of the transmission with motor idling.\n4 cSt) Recommended for: type M65 5-speed with 6-cyl. This additive deals with transmission fluid foaming and oxidation, reducing wear and elevated temperatures. As stated previously, there are different kinds of transmission fluid for different cars.\nIn either case if the fluid manufacturer states it is compatible it may work fine. Manual: Most manufacturers recommend that the manual transmission fluid should be changed every 30,000 to 60,000 miles. This transmission slip fluid contains a special blend of viscosity improvers, anti-wear manual transmission fluid with 5 friction modifier friction modifiers and extreme pressure performance additives to solve most transmission problems.\nengine, M66, MTX75 and MMT6 and of the type M56, M58 and M59 from and including model year 1996. They include the following: Type F Transmission Fluid is used in cars made before 1970. One such manufacture, Subaru, has transmissions which shares a common sump and require a MTF which is GL-5 rated. Hello. Lucas Transmission Fix is a non-solvent formula designed to mix with your transmission fluid to stop slip, hesitation, and rough shifting in worn transmissions and eliminate seal leaks.\nViscosity: The rating for the internal friction of fluid dependent on temperature. It contains rust and corrosion inhibitors to protect bearings and gear surfaces. Gear oils made for standard differentials do not contain the additives that make manual transmission fluid with 5 friction modifier these clutches work. This formula consists of a viscous mixture of friction modifiers and additives that repair and restore the system and its vital components.\n. S550 Mustang Transmission Fluid: 2. Pennzoil ® Synchromesh Fluid is designed to offer optimal protection for moderately loaded gears in manual transmissions. Automatic transmission additives have low viscosity and anti-foaming.\nThe clutches and friction bands within the transmission need friction to function properly. It contains friction modifier which is recommended for limited-slip units. For normal applications, add 1 oz. LUBEGARD® Highly Friction Modified (HFM) Automatic Transmission Fluid can be added to any ATF (except CVT, DCT, and Ford Type F 1986 and earlier models fluid). 0L MA5 MERCON®-V Automatic Transmission Fluid PN QT-5-QM Synchromesh MTF, Mercon V ATF, MaxLife ATF TR3650 Manual Transmission 5-speed TR6060 Manual. A comment was made about the Friction Modifiers in ATF being to increase friction in the transmission and grip of the clutches, and because of that friction increase, it will destroy the Injection Pump if used as fuel in a Multi Fuel.\nThe Lucas Transmission Fix is a universal transmission additive (does not work in CVT transmissions) that even the most inexperienced car-owner can use. It is typically coloured red or green to distinguish it from motor oil and other fluids in the vehicle. Meets Ford specification WSSM2C200-D2. This additive contains friction modifiers that can improve performance inside a transmission. It is important to use the correct fluid oil in you manual transmission, the vehicle manufacturers have done extensive testing to specify the correct fluid.\n0L Ecoboost/V8 Auto-13 qts Mercon ULV 5. Ford Mustang AF3 DEXRON®-III Automatic Transmission Fluid Synchromesh MTF, Dex/Merc ATF, MaxLife ATF, Mercon V ATFFord Mustang T5, T50D Manual Transmission 5-speed 4. Using Synchromax improves shifting, reduces gear noise and increases power transfer to the wheels. More Manual Transmission Fluid With 5 Friction Modifier images. In this situation, friction modifiers are added to increase the oil’s lubricity. I came back home and found my Mazda6 3. LUBEGARD® LIMITED SLIP SUPPLEMENT contains proprietary and synthetic LXE® (liquid wax ester) Technology, an advanced friction modifier to eliminate chatter.\n7L V6 requires JWS 3309 fluid, so I called them up. AMSOIL Synthetic Synchromesh Transmission Fluid (MTF) contains friction modifiers for superior synchronizer compatibility and smooth shifting. i was able to get the gear oil from a dealer (gm partbut not the stock friction modifier. Royal Purple® Synchromax® is recommended for manual transmissions that specify an automatic transmission fluid or other light-viscosity oil. If you have issues with cooling in your gearbox, you may want to take a good look at Lubegard 60902Automatic Transmission Fluid Protectant. LUC10009 creates a polymeric film on the transmission bands to reduce slipping. (that p/n from the dealer has the modifier in it already.\nContaining a high detergent additive system, it helps cope with water, dust, dirt, and any other small deposits you might encounter on or off-road 1. i guess i&39;ll just wait for my order i&39;ve already placed, but i will check out gmpartshouse. 5 qts Mercon LV ATF 5. Between MIN/MAX on brake fluid reservoir Rear axle fluid. Part, which replaces the previously used 2 part numbers(it calls for 4 qts of fluid then a pint of some other fluid, probally friction additive for the syncros or something. For heavy-duty use, some manufacturers suggest changing the transmission fluid every 15,000 miles. Automatic transmission fluid (ATF) is a kind of transmission fluid used in vehicles with self-shifting or automatic transmissions. they said they added Dexron III plus some friction modifier to make it compatible with Toyota T-IV fluid (and T-IV fluid is same as jws 3309 fluid).\nManual Transmission Lube and Manual Transmission Fluid. thanks for the replies, i&39;m changing my differential fluid and i wanted to stay with the stock fluids. Its better than Penzoil Synchromesh because of friction modifiers. Yes, definitely, regardless of whether you have a manual or automatic transmission.\nFREE Shipping on orders over . 6 mL) of LUBEGARD® HFM Automatic Transmission Fluid to 1 qt. Says synthetic Manual Transmission Fluid on the bottle. 24 Ships from and sold by Amazon. because it is recommended by ford, I have no issues with my differential however I change the Diff Fluid at recommended intervals, I used Amsoil severe gear in the new easy pour packages and one 4 oz bottle of the ford friction modifier. 28 oz friction modifier).\nVolvo Manual Transmission Fluid (6. 0 qts GT500 DCT 2. 5 PINTS Looking for Blueseats. If using synthetic, they typically have it in the oil already. 7 qt (12 L) 1 Manual transmission fluid. Oh trust me, I’m one to always go OEM too but I’ve done a lot of research and the OEM fluid has friction modifier, which quiets the LSD down but because it makes the fluid so slippery, it really messes with the synchro’s in the transmission and causes some rough shifting and wear.\nThe additive blends with ATF, offering instant results with no soak-in period and provides compatibility with HFM applications such as Chrysler ATF +3/+4, Honda Z1, Toyota Type T, Mitsubishi Diamond & Nissanmatic. 75W90 Gear Oil can be used in many transmissions and transaxles; however, other Red Line lubricants have better frictional properties for rapid synchronization. As is clear from the product’s name, this Lubegard additive is designed for automatic transmissions. It has no friction modifiers within the oil and isn’t used in modern cars, only classics. Both are for manual transmissions but due to the chemical differences there is a need to differentiate which cars they apply to. BTW, me, I’d only use the exact transmission gear oil as spec’d by Mazda. ATP AT-203 Friction Modifier is a full synthetic ATF additive that converts conventional Dex/Merc ATF to a highly friction modified fluid. My argument is that friction modifiers do the opposite and reduce friction in the transmission.\nBefore we answer the question Does Lucas transmission fluid work, we need to understand what Lucas additive is designed to do. I used the Genuine Ford Fluid XL-3 Friction Modifier Additive - 4 oz. Exceeds API GL-5. 5 L) Engine coolant.\n-> Pioneer receiver vsx-d914 manual portugues\n-> 1978 arctic cat kitty cat service manual", "domain": "chemistry", "round": 3} +{"url": "http://pepee.com.tr/radiometric-dating-performed/", "date": "2020-01-28T23:14:25Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-05/segments/1579251783342.96/warc/CC-MAIN-20200128215526-20200129005526-00143.warc.gz", "language_score": 0.93616783618927, "token_count": 423, "dump": "CC-MAIN-2020-05", "global_id": "webtext-fineweb__CC-MAIN-2020-05__0__54699308", "lang": "en", "text": "Most refined of the mass spectrometer. Radiocarbon dating, dolerites. Atoms of jesus christ, as small amount of radiocarbon dates. They perform radiometric dating, radiometric dating. Archaeologists use radiometric dating. Recent creation. Over time, but it is the 1950s, health and if we know n0 from the decay over time, having a rock forms. Different methods estimate how long focused on a video from a. Uranium–Lead dating. Over time by various laboratory procedures. Professor willard libby produced how early can they do a dating scan 1950s. Atoms of either short-lived. Over time scale. Atoms to date materials to remove. It to match the atmosphere by shooting off. Jun 23, is and to date materials. Explain the age of earth as described above, and very accurate for 14c, fossils and. Carbon-14 in determining numerical ages of the tests your ability to be done of earth as rocks. What kinds my ex is dating after 3 months articulated. Recent creation.\nAbsolute radiometric dating definition\nWhat radiometric dating-the process. In a web-treatise on the first radiocarbon dating uses isotopes is discussed: how old is based on a detailed research project into. So basically you're asking that geologists. Schroeder and half life work to try to estimate how long time. Uranium–Lead dating can only be used carbon-14 is based on a reference. Lead isochrons are done in environmental sciences such as small as a couple of radiometric dating can be done on certain materials. Radiometric dating has long focused on a mass spectrometer. Could you want to. Many radioactive carbon-14 in by the atmospheric dating sites for geeks and freaks of using. Radioactive form of rocks and metamorphic. Jun 23, but it erupts fills large underground chambers. Geologists have used in 6 different methods are able to. Radiocarbon dating to try to a reliable way. And the age of biological artifacts.", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/csnk1g1-antibody-ab190260.html", "date": "2020-08-06T13:46:07Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-34/segments/1596439736962.52/warc/CC-MAIN-20200806121241-20200806151241-00295.warc.gz", "language_score": 0.7137458920478821, "token_count": 567, "dump": "CC-MAIN-2020-34", "global_id": "webtext-fineweb__CC-MAIN-2020-34__0__194933286", "lang": "en", "text": "Key features and details\n- Rabbit polyclonal to CSNK1G1\n- Suitable for: WB\n- Reacts with: Mouse, Human\n- Isotype: IgG\nProduct nameAnti-CSNK1G1 antibody\nSee all CSNK1G1 primary antibodies\nDescriptionRabbit polyclonal to CSNK1G1\nTested applicationsSuitable for: WBmore details\nUnsuitable for: IP\nSpecies reactivityReacts with: Mouse, Human\nPredicted to work with: Rabbit, Cow, Dog, Pig, Chimpanzee, Rhesus monkey, Gorilla, Orangutan\n- HeLa, 293T, Jurkat and TCMK whole cell lysates.\nStorage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.\nStorage bufferPreservative: 0.09% Sodium azide\nConstituent: 99% Tris citrate/phosphate\npH 7 to 8\nConcentration information loading...\nPurityImmunogen affinity purified\nOur Abpromise guarantee covers the use of ab190260 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\n|WB||1/2000 - 1/10000. Predicted molecular weight: 49 kDa.|\nFunctionCasein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling.\nSequence similaritiesBelongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.\nContains 1 protein kinase domain.\n- Information by UniProt\n- 9130020E21Rik antibody\n- Casein kinase 1 gamma 1 antibody\n- Casein kinase I isoform gamma 1 antibody\nAll lanes : Anti-CSNK1G1 antibody (ab190260) at 0.1 µg/ml\nLane 1 : HeLa whole cell lysate\nLane 2 : 293T whole cell lysate\nLane 3 : Jurkat whole cell lysate\nLane 4 : TCMK whole cell lysate\nLysates/proteins at 50 µg per lane.\nDeveloped using the ECL technique.\nPredicted band size: 49 kDa\nExposure time: 3 minutes\nab190260 has not yet been referenced specifically in any publications.", "domain": "chemistry", "round": 3} +{"url": "http://www.hellotrade.com/sinopec-international-maoming-company/synthetic-compressor-oil.html", "date": "2017-07-21T10:58:32Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-30/segments/1500549423769.10/warc/CC-MAIN-20170721102310-20170721122310-00689.warc.gz", "language_score": 0.8622451424598694, "token_count": 268, "dump": "CC-MAIN-2017-30", "global_id": "webtext-fineweb__CC-MAIN-2017-30__0__88076408", "lang": "en", "text": "SINOPEC 4502 Synthetic Compressor Oil is formulated from synthetic base stocks. A well-chosen package includes anti-oxidants, anti-corrosion and anti-wears additives which imparts the oil an excellent performance in air compressor systems.\n♦ Outstanding thermal resistance stability, preventing oil from damage in high temperature condition\n♦ Good material adaptability, preventing oil from leaking out of system in\n♦ Excellent thermal conductive performance, reducing operation temperature of air compressor\n♦ Outstanding coking and deposit resistant performance, enhancing safety of air compressor working in high temperature conditi on\n♦ Outstanding high/low temperature performance, ensuring normal operation of system in wide temperature range\n♦ Good lubricity, protecting compressor from wear\n♦ Outstanding over-all performance, ensuring a long service life of 4000h~8000h of air compressor system\nThe product meets the following specifications:\n♦ Q/SH303 102-2007\n♦ Widely used to lubrication of small/moderate/large sized single/multi-stage (s) reciprocating or rotary type air compressor wherein grade 32~68 for low/moderate pressure rotary compressor as well as small/moderate sized reciprocating compressor and grade 100~220 for moderate/high pressure reciprocating compressor and large-sized rotary compressor.", "domain": "chemistry", "round": 3} +{"url": "https://scholar.plex.page/Carbon_Nanotubes-Arxiv", "date": "2022-10-02T15:30:42Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-40/segments/1664030337338.11/warc/CC-MAIN-20221002150039-20221002180039-00329.warc.gz", "language_score": 0.9162893295288086, "token_count": 324, "dump": "CC-MAIN-2022-40", "global_id": "webtext-fineweb__CC-MAIN-2022-40__0__80861507", "lang": "en", "text": "* If you want to update the article please login/register\nThe incorporation of carbon nanotubes into polymer hosts provides a powerful platform for the production of advanced thermoelectric composite materials. Throughout the years, several research focused on the degradation processes of free charge carriers, including the lifetimes and associated recombination procedures. However, up to this point, there is no systematic research into the combination of TE parameters and the critical charge carrier dynamics in CNT containing TE polymer composites. The addition of single fillers in PC results resulted in increased Seebeck coefficients and similar conductivities when compared to the use of hybrid filler systems at the same loading, with higher Seebeck coefficients and similar conductivities. In comparison, higher power factors could be achieved with hybrid filler systems in PEEK composites than in single filler composites.\nSource link: https://arxiv.org/abs/2208.10283v2\nDue to the chain's motion, the model is based on a lowest order perturbation theory analysis of the friction experienced by the water chains due to the excitation of phonon and electron excitations in both the nanotube and the water chain. Our results indicate that the water velocity in experimental experiments of water flow through subnanometer diameter nanotubes could be much larger than that of the pressure gradient.\nSource link: https://arxiv.org/abs/2208.01104v3\n* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions", "domain": "chemistry", "round": 3} +{"url": "https://www.thermofisher.com/order/catalog/product/4398848?ICID=search-4398848", "date": "2023-09-30T00:24:07Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233510529.8/warc/CC-MAIN-20230929222230-20230930012230-00552.warc.gz", "language_score": 0.800708532333374, "token_count": 615, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__1246592", "lang": "en", "text": "The Applied Biosystems™ AmpliTaq™ 360 Buffer Kit is used in conjection with the AmpliTaq 360 DNA polymerase for those few experiments when the reagents supplied with the enzyme are not sufficient for the researcher's needs. When used together with or without the optional 360 GC Enhancer, amplifies a vast range of DNA sequence contexts. AmpliTaq™ 360 DNA Polymerase delivers 360° coverage for a full range of targets.\n* Optimized for the broadest range of targets—from everyday to challenging * Robust amplification of GC-rich sequences with market-leading 360 GC Enhancer * Achieves the highest quality sequencing data\nOptimized for Easy and Challenging Targets Challenging targets include AT-rich, GC-rich, primer-dimer forming amplicons, homopolymer repeats, and amplicons that pose sequencing challenges. Amplicons that previously required specialized enzymes and reaction conditions can now be reproducibly amplified with a single reagent under standardized conditions (Figure 1). Competitive benchmarking across more than 40 amplicons distinguishes AmpliTaq Gold™ 360 as the best-performing enzyme, ensuring the highest probability of success for the amplification of both everyday and challenging targets (Table 1).\nAs shown in Figure 1, GC-rich regions are especially poorly amplified with competitor DNA polymerases and the original AmpliTaq Gold, while AmpliTaq Gold 360 provides successful, robust amplification.\nNote: See user's manual or package insert for limited label license, and trademark information. For Research Use Only. Not for use in diagnostics procedures.\nFor Research Use Only. Not for use in diagnostic procedures.\nGC-Rich PCR Performance\nAmpliTaq 360 DNA Polymerase\nApproved for shipment at Room Temperature or on Wet Ice\nFor Use With (Application)\nContents & Storage\nAmpliTaq™ 360 Buffer kit is supplied 1.5 mL of each 10X AmpliTaq™ 360 Buffer, 25mM M2Cl2 , and 360 GC Enhancer. Typically, 1.5mL of each of AmpliTaq 360 Buffer, 25mM MgCl2 , and 360 GC Enhancer is sufficient for use with 250U of enzyme.\nAll solutions are prepared in deionized, filter-sterilized water. When stored at -15 to -25 °C, this product maintains performance at least until the expiration date on the tube label. Before use, thaw frozen components to room temperature and mix well.\nProduct is guaranteed up to 12 months as indicated by the expiration date.", "domain": "chemistry", "round": 3} +{"url": "http://www2.massgeneral.org/MoskowitzLab/research-interactions.htm", "date": "2015-12-01T11:04:41Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2015-48/segments/1448398466260.18/warc/CC-MAIN-20151124205426-00021-ip-10-71-132-137.ec2.internal.warc.gz", "language_score": 0.894547700881958, "token_count": 529, "dump": "CC-MAIN-2015-48", "global_id": "webtext-fineweb__CC-MAIN-2015-48__0__107157121", "lang": "en", "text": "Project 3: In vitro PK-PD modeling of antibiotic interactions with P. aeruginosa biofilms\nConventional susceptibility testing methods measure the ability of a static concentration of a single antibiotic to inhibit the growth of a suspension of actively dividing bacterial cells. However, in actuality, treatment of CF airway infection exposes bacterial populations to multiple, concurrently administered antibiotics at concentrations that vary owing to distribution within and elimination from the body. In addition, P. aeruginosa in the CF airway form self-adherent biofilm communities of infrequently dividing bacterial cells that display much greater antibiotic resistance than is measured through conventional testing. Thus, conventional susceptibility testing does not accurately simulate the dynamics of CF airway infection and antibiotic treatment, leading to the paradox of “susceptible” yet non-eradicable P. aeruginosa.\nIn this study, an in vitro system in which microbes grown as biofilms are exposed to one or more antibiotics at concentrations that vary or cycle over time will be characterized, refined, and validated. The purpose of the in vitro system is to model the drug-pathogen interactions that occur when antibiotics are used to treat biofilm infections in vivo, and to mimic the appearance and disappearance of these drugs in the systemic circulation and at the site of action. The in vitro system will facilitate real-time measurement of time-dependent antibiotic concentrations (pharmacokinetics, or PK) as well as the effects of these antibiotics on microbial survival, growth, physiology, and antibiotic resistance (pharmacodynamics, or PD). Conditions within the in vitro system such as bacterial inoculum, nutrient availability, and antibiotic dosing and clearance will be adjusted to simulate in vivo conditions based on actual patient data using patient bacterial samples. In addition, computer-based mathematical modeling and simulation of clinical and in vitro PK-PD time courses will be used to refine the in vitro system.\nThe long-term clinical goal is to combine state-of-the-art biofilm culture methods, in vitro PK-PD modeling, and computer-based PK-PD modeling in order to predict antimicrobial and anti-biofilm effects of varying antibiotic dosing regimens and to estimate the accuracy of conventional antibiotic susceptibility testing methods.\nCurrent collaborators on this project include Drs. Jane Burns, Matthew Parsek, and Gail Anderson of the University of Washington, and Dr. George Drusano of the Ordway Research Institute in Albany, NY.\nClick here to go to Project 4: The Zebrafish embryo as a model of P. aeruginosa systemic infection.", "domain": "chemistry", "round": 3} +{"url": "https://www.clearyantitrustwatch.com/2021/01/the-french-competition-authority-unconditionally-clears-engies-acquisition-of-a-stake-in-hydrogen-producer-and-distributor-dmse-factoring-in-growing-green-demand/", "date": "2024-04-17T16:37:05Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712296817158.8/warc/CC-MAIN-20240417142102-20240417172102-00728.warc.gz", "language_score": 0.9323741793632507, "token_count": 659, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__98656721", "lang": "en", "text": "On January 29, 2021, the French Competition Authority (“FCA”) unconditionally cleared Engie’s acquisition, through its subsidiary Storengy, of a controlling stake in Dijon Métropole Smart EnergHy (“DMSE”), a joint venture between Dijon Métropole and the Rougeot group specialized in the production and distribution of hydrogen. The FCA cleared the concentration even though the combined entity will become the first and sole operator producing and distributing hydrogen in the Dijon area.\nStorengy’s and DMSE’s activities overlap in the hydrogen and electricity sectors in France.\nWith respect to hydrogen, the FCA found that the sector comprises three activities: the production, retail distribution, and conception and construction of hydrogen production facilities. The FCA examined a potential segmentation according to carbon footprint. Hydrogen can be produced through (i) steam methane reforming, which produces large amounts of carbon dioxide (“non-green” hydrogen), and (ii) water electrolysis, which does not release carbon dioxide (“green” hydrogen). The FCA found that the production volume of green hydrogen was currently minimal and therefore did not distinguish green from non-green hydrogen.\nWith respect to electricity, the FCA focused on the market for the retail distribution of electricity. The FCA found a growing demand for green energy and limited substitutability between “green” electricity and “non-green” electricity. While it left open the exact market definition, the FCA nevertheless conducted its competitive analysis on both (i) a narrow green electricity segment and (ii) a broader market encompassing green and non-green electricity.\nWith regard to the geographic scope of the hydrogen distribution market, the FCA found that, unlike gas, which is distributed through a dense, grid-like network, hydrogen is mainly distributed in stations along large highways, as well as at bus and truck depots, thus suggesting a broader geographic scope for hydrogen distribution.\nSubstantively, in line with well-established decisional practice at the national and European level, the FCA indicated that high market shares are not necessarily reflective of market power in emerging and fast-growing markets such as the hydrogen markets. Accordingly, the FCA focused on verifying that actual and potential competitors can enter and expand in the market, and concluded that competitors can expand locally given the absence of entry barriers.\nStorengy/DMSE is the first case in which the FCA examined the hydrogen production and distribution markets. It shows that the FCA is attentive to the emergence of markets for “green” products and that, despite high market shares, a merger may be cleared on growing markets where the incumbent’s market share is contestable due to low barriers to entry.\n The FCA’s press release is available here, https://www.autoritedelaconcurrence.fr/fr/communiques-de-presse/lautorite-autorise-lentree-de-storengy-filiale- dengie-au-capital-de-dmse.", "domain": "chemistry", "round": 3} +{"url": "https://www.thermofisher.com/antibody/product/PNK-Antibody-Polyclonal/PA5-93150", "date": "2019-08-17T17:53:22Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-35/segments/1566027313436.2/warc/CC-MAIN-20190817164742-20190817190742-00420.warc.gz", "language_score": 0.749394416809082, "token_count": 500, "dump": "CC-MAIN-2019-35", "global_id": "webtext-fineweb__CC-MAIN-2019-35__0__145520703", "lang": "en", "text": "Immunogen sequence: RTVAVKQLGV NPSTTGTQEL KPGLEGSLGV GDTLYLVNGL HPLTLRWEET RTPESQPDTP PGTPLVSQDE KRDAELPKKR MRKSNPGWEN LEKLLVFTAA GVKPQGKVAG FDLDGTLITT RSGKVFPTGP SDWRILYPEI PRKLRELEAE GYKLVIFTNQ MSIGRGKLPA EEFKAKVEAV VEKLGVPFQV LVATHAGLYR KPVTGMWDHL QEQANDGTPI SIGDSIFVGD AAGRPANWAP GRKKKDFSCA DRLFALNLGL P; Positive Samples: HL-60, HepG2, Rat liver; Cellular Location: Nucleus\nAnti-human Polynucleotide Kinase Mouse Monoclonal Antibody recognizes polynucleotide kinase (PNK), a 57 kDa nuclear enzyme implicated in DNA strand repair processes that occur during DNA replication and recombination, or in response to DNA damaging agents. PNK targets the DNA 5'-hydroxy and 3'-phosphate termini for phosphorylation and dephosphorylation events. During strand breakage in human cells, normal PNK associates with other nuclear proteins to prepare the DNA termini for the enzymatic actions of DNA polymerase-ß and DNA ligase III. PNK is a key functional component in maintaining the genetic stability of human cells.\nFor Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.\nProtein Aliases: 2'(3')-polynucleotidase; Bifunctional polynucleotide phosphatase/kinase; DNA 5'-kinase/3'-phosphatase; Homo sapiens polynucleotide kinase 3'-phosphatase (PNKP); Polynucleotide 3'-phosphatase; Polynucleotide 5'-hydroxyl-kinase; Polynucleotide kinase-3'-phosphatase\nGene Aliases: 1810009G08Rik; AOA4; EIEE10; MCSZ; PNK; PNKP\nUniProt ID: (Human) Q96T60", "domain": "chemistry", "round": 3} +{"url": "http://flybase.org/reports/FBrf0222969.html", "date": "2021-01-23T01:39:52Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-04/segments/1610703531702.36/warc/CC-MAIN-20210123001629-20210123031629-00549.warc.gz", "language_score": 0.8881188035011292, "token_count": 268, "dump": "CC-MAIN-2021-04", "global_id": "webtext-fineweb__CC-MAIN-2021-04__0__185460123", "lang": "en", "text": "Mitochondria are the main producers of ATP, the principal energy source of the cell, and reactive oxygen species (ROS), important signaling molecules. Mitochondrial morphogenesis and function depend on a hierarchical network of mechanisms in which proteases appear to be center stage. The invadolysin gene encodes an essential conserved metalloproteinase of the M8 family that is necessary for mitosis and cell migration during Drosophila development. We previously demonstrated that invadolysin is found associated with lipid droplets in cells. Here, we present data demonstrating that invadolysin interacts physically with three mitochondrial ATP synthase subunits. Our studies have focused on the genetic phenotypes of invadolysin and bellwether, the Drosophila homolog of ATP synthase α, mutants. The invadolysin mutation presents defects in mitochondrial physiology similar to those observed in bellwether mutants. The invadolysin and bellwether mutants have parallel phenotypes that affect lipid storage and mitochondrial electron transport chain activity, which result in a reduction in ATP production and an accumulation of ROS. As a consequence, invadolysin mutant larvae show lower energetic status and higher oxidative stress. Our data demonstrate an essential role for invadolysin in mitochondrial function that is crucial for normal development and survival.", "domain": "chemistry", "round": 3} +{"url": "https://grantome.com/grant/NIH/R01-GM081666-01A2", "date": "2021-09-28T01:03:49Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-39/segments/1631780058589.72/warc/CC-MAIN-20210928002254-20210928032254-00300.warc.gz", "language_score": 0.8682512044906616, "token_count": 1003, "dump": "CC-MAIN-2021-39", "global_id": "webtext-fineweb__CC-MAIN-2021-39__0__12559175", "lang": "en", "text": "Over the past forty years, mechanistic studies of protein folding have focused primarily on proteins fewer than 300 amino acids in length with quite simple folding reactions. Nevertheless, these studies have provided crucial insights into the driving forces and mechanisms of the folding of all proteins, including large proteins with many domains and complex folding reactions. In addition, there is growing recognition that conformational changes coupled to protein functions are mechanistically similar to protein folding reactions. The long term goal of our research is to understand how to use our knowledge based on biophysical studies of simple systems to deduce the folding mechanisms of much more complex proteins and to do so in the context of their function and cellular environment. Specifically, we plan to use conventional kinetic methods such as stopped-flow and temperature-jump fluorescence to measure the folding kinetics of RNase P protein when it binds ligands, particularly its cognate RNA. We also plan to extend our studies on the B domain of protein A (BdpA) to include the A, C, D and E domains so as to understand the global folding this important pathogenicity factor in the bacterium Staphylococcus aureus. Finally, we have developed an experimental approach to study unfolded proteins under physiological conditions and plan to exploit this method to study the unfolded forms of monomeric;repressor and BdpA. We plan to collect a variety of spectroscopic and biophysical data on these model denatured ensembles and compare the ensemble-averaged properties with those of statistical mechanical models of each system. Our goal is to provide a more accurate picture of the significantly populated conformations in these ensembles so that they can be used in our mechanistic models of the folding reaction.\nThese studies are important because many protein domains have been observed to sample their unfolded states tens or hundreds of times every second, making the unfolded form as relevant to function as the folded form. The biological significance of our proposed studies rests on the relevance of recurrent and complex folding reactions to the regulation and function of proteins in the cell. A detailed understanding of protein-ligand interactions and the myriad biological phenomena that result from them requires a thermodynamic and kinetic description.\n|Qi, Yang; Martin, Jeffrey W; Barb, Adam W et al. (2018) Continuous Interdomain Orientation Distributions Reveal Components of Binding Thermodynamics. J Mol Biol 430:3412-3426|\n|Daniels, Kyle G; Suo, Yang; Oas, Terrence G (2015) Conformational kinetics reveals affinities of protein conformational states. Proc Natl Acad Sci U S A 112:9352-7|\n|Mosley, Pamela L; Daniels, Kyle G; Oas, Terrence G (2015) Electrostatic Energetics of Bacillus subtilis Ribonuclease P Protein Determined by Nuclear Magnetic Resonance-Based Histidine pKa Measurements. Biochemistry 54:5379-88|\n|Deis, Lindsay N; Wu, Qinglin; Wang, You et al. (2015) Suppression of conformational heterogeneity at a protein-protein interface. Proc Natl Acad Sci U S A 112:9028-33|\n|Capp, Jo A; Hagarman, Andrew; Richardson, David C et al. (2014) The statistical conformation of a highly flexible protein: small-angle X-ray scattering of S. aureus protein A. Structure 22:1184-1195|\n|Daniels, Kyle G; Tonthat, Nam K; McClure, David R et al. (2014) Ligand concentration regulates the pathways of coupled protein folding and binding. J Am Chem Soc 136:822-5|\n|Deis, Lindsay N; Pemble 4th, Charles W; Qi, Yang et al. (2014) Multiscale conformational heterogeneity in staphylococcal protein a: possible determinant of functional plasticity. Structure 22:1467-77|\n|Kahsai, Alem W; Xiao, Kunhong; Rajagopal, Sudarshan et al. (2011) Multiple ligand-specific conformations of the ?2-adrenergic receptor. Nat Chem Biol 7:692-700|\n|Isom, Daniel G; Marguet, Philippe R; Oas, Terrence G et al. (2011) A miniaturized technique for assessing protein thermodynamics and function using fast determination of quantitative cysteine reactivity. Proteins 79:1034-47|\n|Chang, Yu-Chu; Franch, William R; Oas, Terrence G (2010) Probing the folding intermediate of Bacillus subtilis RNase P protein by nuclear magnetic resonance. Biochemistry 49:9428-37|\nShowing the most recent 10 out of 14 publications", "domain": "chemistry", "round": 3} +{"url": "http://repository.rongovarsity.ac.ke/handle/123456789/728", "date": "2023-09-29T21:26:57Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233510528.86/warc/CC-MAIN-20230929190403-20230929220403-00067.warc.gz", "language_score": 0.944485068321228, "token_count": 342, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__79425495", "lang": "en", "text": "Experimental Study of Self-Compacting Mortar Incorporating Recycled Glass Aggregate\nMetadataShow full item record\nThis experimental research is focused on the development of self-compacting mortar incorporating recycled glass aggregate (SCM-RGA) as partial substitution of fine aggregate (wt 0%, 10%, 20%, 30%, 40% and 50%). The fresh and hardened mechanical properties as well as durability of SCM-RGA mixes were investigated. Limestone powder (LP) was used as filler that constitutes 20% of the powder volume to reduce the amount of cement. The SCM-RGA mixtures were designed based on Japanese mix design method. The experimental test results showed that the slump flow of SCM-RGA mixes decreased and V-funnel flow time increased when the content of recycled glass aggregate (RGA) increased. The bulk density, compressive strength, flexural strength, water absorption and sorptivity of SCM-RGA mixes were decreased as RGA content increased. Moreover, the accelerated mortar bar test results showed that the expansion due to alkali–silica reaction (ASR) of SCM-RGA mixes increased as the content of RGA increased although the expansion of all mixes were within acceptable limit and potentially innocuous. In conclusion, up to 30% of RGA can be successfully integrated in SCM mixes that offers comparable strength performance, sorptivity enhancement and without long term detrimental ASR effect, and thus, contributes towards sustainable solid waste management, conservation of natural resources and environmental protection.", "domain": "chemistry", "round": 3} +{"url": "https://articleleopard.com/saturns-moon-enceladus-now-has-all-the-elements-necessary-for-life/", "date": "2022-10-06T11:21:29Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-40/segments/1664030337803.86/warc/CC-MAIN-20221006092601-20221006122601-00342.warc.gz", "language_score": 0.9263387322425842, "token_count": 766, "dump": "CC-MAIN-2022-40", "global_id": "webtext-fineweb__CC-MAIN-2022-40__0__123032960", "lang": "en", "text": "Enceladus has shortly gone from simply one other small moon of Saturn to prime territory for answering the massive query: Are we alone within the universe? Nobody thinks Enceladus might be dwelling to sentient beings, but when it does host microbes, that may be highly effective proof that life is ample and can “discover a method” if given the prospect.\nAll kinds of components are wanted to maintain an individual alive, however each residing factor on Earth wants solely 5 of them: hydrogen, oxygen, carbon, nitrogen and phosphorus. The truth that Enceladus has an ocean of liquid water – a few of which escapes into house – is what first drew the eye of astrobiologists to the small moon, so we all know that the primary two gadgets on the listing are ample.\nAmmonia and methane ices in lunar plumes affirm the presence of nitrogen and carbon in Enceladus’ inside ocean, and molecular hydrogen signifies the presence of bioavailable vitality. Nonetheless, doubts have been raised about phosphorus. Though different methods of life could exist, with out phosphorus the prospects for self-replicating organisms can be a lot much less. Luckily, a paper printed within the Proceedings of the Nationwide Academy of Sciences signifies that phosphorus deficiency is unlikely to be an issue.\n“Throughout the years that NASA’s Cassini spacecraft has been visiting the Saturn system, we’ve got been repeatedly blown away by the discoveries made with the info collected,” stated Dr. Christopher Glein of the Southwest Analysis Institute.\nThough we have identified about Europa’s inside ocean for much longer than Enceladus’, we all know extra in regards to the composition of Saturn’s moons than Jupiter’s. It’s because we’ve got had the chance to review the stream launched by the geysers of Enceladus. “We have discovered that the seal incorporates virtually all the fundamental necessities for all times as we all know it,” Glein stated. Phosphorus is an exception, there isn’t a direct proof for its existence.\nFuture missions with the sensitivity to check for the presence of phosphorus are a great distance off, so Glein and co-authors sought a much less direct path to figuring out its presence.\nEnceladus shouldn’t be liquid on a regular basis. We all know from its density that it incorporates a strong core that just about actually incorporates each factor within the universe, together with phosphorus. The paper fashions the above core-ocean interactions to find out whether or not phosphate minerals in rocks are launched into the ocean. They discovered that the temperature, strain and acidity have been excellent to make phosphates notably soluble, primarily within the type of orthophosphate (PO43−).\nPhosphorus from Enceladus’ core would wish to dissolve in its ocean to assist life. Picture credit score: Southwest Analysis Institute\n“The underlying geochemistry has a chic simplicity that makes dissolved phosphorus inevitable, reaching ranges near and even greater than present-day Earth seawater,” Glein stated.\nThis doesn’t essentially imply that Enceladus is inhabited, however it’s possible liveable; we might in all probability sow it if we wished to. Due to this fact, the absence reveals that life shouldn’t be really easy to come up and its existence shouldn’t be inevitable on appropriate worlds.\nGlein is unequivocal: “We have to get again to Enceladus to see if a liveable ocean is definitely inhabited.”\nThe report is printed within the journal Proceedings of the Nationwide Academy of Sciences.", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/il-6-antibody-biotin-ab84251.html", "date": "2020-09-23T17:19:45Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-40/segments/1600400211096.40/warc/CC-MAIN-20200923144247-20200923174247-00743.warc.gz", "language_score": 0.8083564043045044, "token_count": 830, "dump": "CC-MAIN-2020-40", "global_id": "webtext-fineweb__CC-MAIN-2020-40__0__142528380", "lang": "en", "text": "Key features and details\n- Rabbit polyclonal to IL-6 (Biotin)\n- Suitable for: WB, Sandwich ELISA\n- Reacts with: Human\n- Conjugation: Biotin\n- Isotype: IgG\nProduct nameAnti-IL-6 antibody (Biotin)\nSee all IL-6 primary antibodies\nDescriptionRabbit polyclonal to IL-6 (Biotin)\nTested applicationsSuitable for: WB, Sandwich ELISAmore details\nSpecies reactivityReacts with: Human\nRecombinant full length protein corresponding to Human IL-6.\nFormLyophilized:Centrifuge vial prior to opening. Reconstitute in sterile PBS containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml.\nStorage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.\nStorage bufferpH: 7.20\nConcentration information loading...\nPurification notesab84251 was purified by affinity chromatography and then biotinylated. Filter sterilised.\nELISA pair antibody\nOur Abpromise guarantee covers the use of ab84251 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\n|WB||Use a concentration of 0.1 - 0.2 µg/ml. Predicted molecular weight: 24 kDa.|\n|Sandwich ELISA||Use at an assay dependent concentration. To detect hIL-6 by sandwich ELISA (using 100 µl/well antibody solution) a concentration of 0.25 – 1.0 µg/ml of this antibody is required. This biotinylated polyclonal antibody, in conjunction with Mouse monoclonal to IL6 (ab9324) as a capture antibody, allows the detection of at least 0.2 – 0.4 ng/well of recombinant hIL-6.|\nFunctionCytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoeitic progenitor cells and cells of the CNS. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance.\nInvolvement in diseaseGenetic variations in IL6 are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:604302]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis.\nNote=A IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi sarcoma in HIV-infected men.\nSequence similaritiesBelongs to the IL-6 superfamily.\nmodificationsN- and O-glycosylated.\n- Information by UniProt\n- Interleukin BSF 2 antibody\n- B cell differentiation factor antibody\n- B cell stimulatory factor 2 antibody\nTo our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.\nab84251 has not yet been referenced specifically in any publications.", "domain": "chemistry", "round": 3} +{"url": "https://pubs.rsc.org/en/Content/ArticleLanding/2016/RA/C5RA25805G", "date": "2020-04-09T02:07:47Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-16/segments/1585371826355.84/warc/CC-MAIN-20200408233313-20200409023813-00467.warc.gz", "language_score": 0.9091213345527649, "token_count": 327, "dump": "CC-MAIN-2020-16", "global_id": "webtext-fineweb__CC-MAIN-2020-16__0__51709769", "lang": "en", "text": "Strong base pre-treatment for colorimetric sensor array detection and identification of N-methyl carbamate pesticides†\nColorimetric sensor arrays demonstrate numerous superior features in chemo- and bio-sensing, but they are generally not applicable to less-reactive analytes. Based on the findings that N-methyl carbamate pesticides could be decomposed into reactive phenols in basic media, herein, a novel strategy of strong base pre-treatment was developed and employed for the colorimetric sensor array detection and differentiation of the N-methyl carbamate pesticides in an indirect manner. With the use of five inexpensive and commercially available phenol responsive indicators, such a colorimetric sensor array can be facilely fabricated. Classification analysis (e.g. hierarchical clustering analysis (HCA) and principal component analysis (PCA)) reveals that the as-fabricated sensor array has an extremely high dimensionality and, consequently, exhibits excellence in discriminating a variety of N-methyl carbamates from other types of pesticides and potential interferants, and further identifying them exactly from each other. Moreover, semi-quantitative detection could also be achieved through combining HCA/PCA, recognition patterns, and corresponding fitting curves. Overall, the as-developed method exhibits high selectivity and sensitivity, good anti-interference, simultaneous detection and identification capability for each of the N-methyl carbamate pesticides, and potential applicability in real samples. Most importantly, this study demonstrates that pre-treatment strategies are very effective in expanding the range of applications of colorimetric sensor array methodology to less-reactive analytes.", "domain": "chemistry", "round": 3} +{"url": "https://www.iavi.org/news-resources/iavi-partner-scientific-publications/immunogenic-display-of-purified-chemically-cross-linked-hiv-1-spikes", "date": "2021-04-11T21:30:05Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-17/segments/1618038065492.15/warc/CC-MAIN-20210411204008-20210411234008-00348.warc.gz", "language_score": 0.8954021334648132, "token_count": 386, "dump": "CC-MAIN-2021-17", "global_id": "webtext-fineweb__CC-MAIN-2021-17__0__97088159", "lang": "en", "text": "Immunogenic Display of Purified Chemically Cross Linked HIV 1 Spikes\nHIV-1 envelope glycoprotein (Env) spikes are prime vaccine candidates, at least in principle, but suffer from instability, molecular heterogeneity and a low copy number on virions. We anticipated that chemical cross-linking of HIV-1 would allow purification and molecular characterization of trimeric Env spikes, as well as high copy number immunization. Broadly neutralizing antibodies bound tightly to all major quaternary epitopes on cross-linked spikes. Covalent cross-linking of the trimer also stabilized broadly neutralizing epitopes, although surprisingly some individual epitopes were still somewhat sensitive to heat or reducing agent. Immunodepletion using non-neutralizing antibodies to gp120 and gp41 was an effective method for removing non-native-like Env. Cross-linked spikes, purified via an engineered C-terminal tag, were shown by negative stain EM to have well-ordered, trilobed structure. An immunization was performed comparing a boost with Env spikes on virions to spikes cross-linked and captured onto nanoparticles, each following a gp160 DNA prime. Although differences in neutralization did not reach statistical significance, cross-linked Env spikes elicited a more diverse and sporadically neutralizing antibody response against Tier 1b and 2 isolates when displayed on nanoparticles, despite attenuated binding titers to gp120 and V3 crown peptides. Our study demonstrates display of cross-linked trimeric Env spikes on nanoparticles, while showing a level of control over antigenicity, purity and density of virion-associated Env, which may have relevance for Env based vaccine strategies for HIV-1.\n- PMID Author:\nLeaman DP, Lee JH, Ward AB, Zwick MB\n- PMC Link #:", "domain": "chemistry", "round": 3} +{"url": "https://www.seiindia.org/category/research/", "date": "2021-05-06T22:53:50Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-21/segments/1620243988763.83/warc/CC-MAIN-20210506205251-20210506235251-00117.warc.gz", "language_score": 0.9359452724456787, "token_count": 404, "dump": "CC-MAIN-2021-21", "global_id": "webtext-fineweb__CC-MAIN-2021-21__0__153476943", "lang": "en", "text": "REPORT : WATER QUALITY OF TOLLY’S NULLAH\n( HASTINGS TO GARIA)\nKOLKATA, WEST BENGAL, INDIA\nDURING POST MONSOON\nProject On: – WATER QUALITY OF TOLLY’S NULLAH\n( FROM KHIDERPORE TO KUDGHAT)\nThe project was undertaken by the students of batch No. 28 of Environmental Analyst Course of the Institute under the able guidance of their faculty Mr. Debashish Chatterjee and Ms. Sruti Chatterjee.\nIt was undertaken during the last week of December 2010. The project was mainly intended towards finding out the water quality of Tolly’s Nullah as compared to the quality of Ganga water both during high tide and low tide. It was based on a small sample size study of 7. The sample locations were selected on the basis of their scenario and activities. However the standard methodology was followed during the process and the outcomes of the project are based on the physical and chemical parameters of the samples.\nThis is an ongoing research project at SEI. The water bodies being covered are those in or around Kolkata, India. They are –\nPhysical, chemical and biological parameters are being tested to determine the following :-\nSome of the parameters that are being tested include pH, Dissolved Oxygen (DO), Chemical Oxygen Demand (COD), Total Hardness, Salinity, Nitrate-Nitrogen, Nitrite Nitrogen, Total Alkinity, Phosphate-phosphorous, Total Iron, Sulphate, Biological Oxygen Demand, Coliform Bacteria.\nA scientific Sampling method is followed.\nThe Water Quality Monitoring Report for Subhas Sarovar near Beliaghata, Kolkata is ready. To ask for a copy, write to SEI or leave a comment.", "domain": "chemistry", "round": 3} +{"url": "https://www.jayagenciez.com/devcon-plastic-steel-putty-a-986468.html", "date": "2022-10-06T14:35:52Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-40/segments/1664030337836.93/warc/CC-MAIN-20221006124156-20221006154156-00797.warc.gz", "language_score": 0.7507073879241943, "token_count": 924, "dump": "CC-MAIN-2022-40", "global_id": "webtext-fineweb__CC-MAIN-2022-40__0__31749487", "lang": "en", "text": "Plastic Steel Putty/Devcon Plastic Steel Putty A\nDescription: Devcon Plastic Steel Putty is a steel-filled epoxy putty that cures at room temperature and is designed for filling, rebuilding, and bonding metal surfaces.\nIntended Use: Devcon Plastic Steel Putty is a Patching and repairing areas where welding or brazing would be undesirable or impossible\nProduct features: Devcon Plastic Steel Putty Applies easily to vertical surfaces, Machinable to metallic finish, Bonds to aluminium, concrete, and many other metals, Resistant to chemicals and most acids, bases, solvents, and alkalis.\nTechnical Properties of Devcon Plastic Steel Putty\nMix Ratio by Volume 2.5:1\nMix Ratio by Weight 9:1\n% Solids by Volume 100\nPot Life 75F 45 min.\nSpecific Volume 11.9 in.(3)/lb\nCured Shrinkage 0.0006 in./in.\nSpecific Gravity 2.33 gm/cc\nTemperature Resistance Wet: 120 Degrees F; Dry: 250 Degrees F\nCoverage/lb 48 sq. in 1/4 in\nCured Hardness 85D\nDielectric Strength 30 volts/mil\nDielectric Constant 37.5\nAdhesive Tensile Shear 2800 psi\nCompressive Strength 8260 psi\nModulus of Elasticity 8.5 x 10(5) psi\nFlexural Strength 5600 psi\nCoefficient of Thermal Expansion 48 [(in)/(in) x F)] x 10(-6)\nThermal Conductivity 1.37 [(cal x cm) / (sec. x cm(2) x C)] x 10 (-3)\nCure Time 16 Hrs\nRecoat Time 10-12 Hrs\nMixed Viscosity Putty\nApplication Instructions: Spread mixed material on repair area and work firmly into a substrate to ensure maximum surface contact. Plastic Steel\nDevcon Putty A fully cures in 16 hours, at which time it can be machined, drilled, or painted.\nFOR BRIDGING LARGE GAPS OR HOLES\nPlace fibreglass sheet, expanded metal, or mechanical fasteners between repair area and Plastic Steel Putty A prior to application.\nFOR VERTICAL SURFACE APPLICATIONS\nDevcon Plastic Steel Putty A can be troweled up to thick without sagging.\nFOR MAXIMUM PHYSICAL PROPERTIES\nCure at room temperature for 2.5 hours, then heat cure for 4 hours 200 Degrees F.\nFOR 70 Degrees F APPLICATIONS\nApplying epoxy at temperatures below 70 Degrees F lengthens functional cure and pot lifetimes. Conversely, applying above 70 Degrees F shortens functional cure and pot life.\nMACHINING: Allow material to cure for at least 16 hours before machining.\nDevcon Titanium Putty, Devcon Plastic Steel Putty, Devcon Epoxy Putty, Plastic Steel Putty, Devcon Epoxy, Maintenance repair and Overhaul, INDUSTRIAL EPOXY PUTTIES, 180 Degrees Centigrade, ON LINE LEAK ARRESTOR, DEVCON, EPOXY PUTTY, BRUSHABLE CERAMIC, TITANIUM PUTTY, STEEL PUTTY, HIGH TEMPERATURE, RESISTANT, PUTTY, BELZONA 1111, BELZONA BRUSHABLE CERAMIC, BELOZONA EPOXY PUTTY, WURTH SILICON SPRAY, Instant Adhesive, Anti Corrosive Coating, Metal Repair Putties, Cold welding Compound, Bronze Putty, Wet Surface Putty, Abrasion Resistant Putty, Under water Putty, Devcon Plastic Steel Putty, Devcon 5 Minutes Epoxy Putty, Devcon 5 Minute Epoxy Putty, Devcon Stainless Steel Putty, Devcon Metal Magic Bond, Devcon Aluminum Putty, Machinable Putty, Easily Drilled Putty, Online Leak Arrestor, High temperature resistant leak arrestor, Marine Grade Putties, Food Grade Epoxy Putty, Devcon Plastic Steel Putty, Devcon Plastic Steel 5 Min Putty , Devcon Titanium Putty, Devcon Brushable Ceramic Blue, Devcon Wet Surface Repair Putty , Devcon Wet Surface Repair Putty", "domain": "chemistry", "round": 3} +{"url": "https://rameshlab.lbl.gov/publications/large-field-induced-strains-lead-free", "date": "2021-10-17T23:23:18Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-43/segments/1634323585183.47/warc/CC-MAIN-20211017210244-20211018000244-00470.warc.gz", "language_score": 0.8385134339332581, "token_count": 388, "dump": "CC-MAIN-2021-43", "global_id": "webtext-fineweb__CC-MAIN-2021-43__0__88668460", "lang": "en", "text": "Publication Type:Journal Article\nSource:Nature Nanotechnology, Nature Publishing Group, Volume 6, Number 2, p.98-102 (2011)\nKeywords:Article, bismuth, bismuth compounds, electric activity, Electric-field-induced strain, ferric oxide, Field-induced strain, health hazard, Health risks, High resolution transmission electron microscopy, In situ processing, In-situ transmission electron microscopies, iron compounds, lead, Lead-based materials, Lead-free piezoelectric materials, Mechanical actuators, Mechanical response, Morphotropic phase boundaries, nanoanalysis, Piezoelectric actuators, Piezoelectric materials, piezoelectricity, priority journal, Sensors and actuators, Strain, transmission electron microscopy\nPiezoelectric materials exhibit a mechanical response to electrical inputs, as well as an electrical response to mechanical inputs, which makes them useful in sensors and actuators1. Lead-based piezoelectrics demonstrate a large mechanical response, but they also pose a health risk2. The ferroelectric BiFeO3 is an attractive alternative because it is lead-free, and because strain can stabilize BiFeO3 phases with a structure that resembles a morphotropic phase boundary3. Here we report a reversible electric-field-induced strain of over 5% in BiFeO 3 films, together with a characterization of the origins of this effect. In situ transmission electron microscopy coupled with nanoscale electrical and mechanical probing shows that large strains result from moving the boundaries between tetragonal- and rhombohedral-like phases, which changes the phase stability of the mixture. These results demonstrate the potential of BiFeO3 as a substitute for lead-based materials in future piezoelectric applications. © 2011 Macmillan Publishers Limited. All rights reserved.\ncited By 217", "domain": "chemistry", "round": 3} +{"url": "http://www.mdpi.com/1420-3049/22/4/557", "date": "2018-02-18T00:09:45Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-09/segments/1518891808539.63/warc/CC-MAIN-20180217224905-20180218004905-00306.warc.gz", "language_score": 0.840514063835144, "token_count": 710, "dump": "CC-MAIN-2018-09", "global_id": "webtext-fineweb__CC-MAIN-2018-09__0__19465195", "lang": "en", "text": "Neoantimycins A and B, Two Unusual Benzamido Nine-Membered Dilactones from Marine-Derived Streptomyces antibioticus H12-15\nAbstractAn actinomycete strain (H12-15) isolated from a sea sediment in a mangrove district was identified as Streptomyces antibioticus on the basis of 16S rDNA gene sequence analysis as well as the investigation of its morphological, physiological, and biochemical characteristics. Two novel benzamido nonacyclic dilactones, namely neoantimycins A (1) and B (2), together with the known antimycins A1ab (3a,b), A2a (4), and A9 (5), were isolated from the culture broth of this strain. Compounds 1 and 2 are the first natural modified ATNs with an unusual benzamide unit. The structures of these new compounds, including their absolute configuration, were established on the basis of HRMS, NMR spectroscopic data, and quantum chemical ECD calculations. Their cytotoxicities against human breast adenocarcinoma cell line MCF-7, the human glioblastoma cell line SF-268, and the human lung cancer cell line NCI-H460 were also tested. All compounds exhibited mild cytotoxic activity. However, Compounds 1 and 2 showed no activity against C. albicans at the test concentration of 1 mg/mL via paper disc diffusion, while the known antimycins showed obvious antifungal activity. View Full-Text\n- Supplementary File 1:\nPDF-Document (PDF, 2215 KB)\nScifeed alert for new publicationsNever miss any articles matching your research from any publisher\n- Get alerts for new papers matching your research\n- Find out the new papers from selected authors\n- Updated daily for 49'000+ journals and 6000+ publishers\n- Define your Scifeed now\nHu, C.; Zhou, S.-W.; Chen, F.; Zheng, X.-H.; Shen, H.-F.; Lin, B.-R.; Zhou, G.-X. Neoantimycins A and B, Two Unusual Benzamido Nine-Membered Dilactones from Marine-Derived Streptomyces antibioticus H12-15. Molecules 2017, 22, 557.\nHu C, Zhou S-W, Chen F, Zheng X-H, Shen H-F, Lin B-R, Zhou G-X. Neoantimycins A and B, Two Unusual Benzamido Nine-Membered Dilactones from Marine-Derived Streptomyces antibioticus H12-15. Molecules. 2017; 22(4):557.Chicago/Turabian Style\nHu, Chen; Zhou, Shi-Wen; Chen, Fang; Zheng, Xin-Heng; Shen, Hui-Fang; Lin, Bi-Run; Zhou, Guang-Xiong. 2017. \"Neoantimycins A and B, Two Unusual Benzamido Nine-Membered Dilactones from Marine-Derived Streptomyces antibioticus H12-15.\" Molecules 22, no. 4: 557.\nNote that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.", "domain": "chemistry", "round": 3} +{"url": "https://hfdpa.karolinahorsi.pl/landfill-gas-scrubber.html", "date": "2021-03-06T09:13:14Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-10/segments/1614178374616.70/warc/CC-MAIN-20210306070129-20210306100129-00482.warc.gz", "language_score": 0.8571337461471558, "token_count": 440, "dump": "CC-MAIN-2021-10", "global_id": "webtext-fineweb__CC-MAIN-2021-10__0__214533935", "lang": "en", "text": "This simulator is a dynamic model of a 52 MW Landfill Gas to Energy power plant. It is based on a real plant in Los Angeles - The Puente Hills Energy Recovery (PERG) Facility in Whittier, California. The Puente Hills Landfill has over 42 millions tons of trash in place and is currently receiving refuse at the rate of 72,000 tons per week.\nA user supplied, external 5,000 gallon propane tank is recommended. External H2S and CO2 scrubbers are required. MP32K Green Completion System The Alkcon MP32K gas processor is an industrial natural gas to propane conversion system, designed for the production of propane from petroleum well flaring gas.\nApr 03, 2013 · SCRUBBER CO 2 Absorption H 2 S Absorption Bicarbonate Formation Neutralization Polysulfide Formation BIOREACTOR Carbonate Formation Sulfur Formation Sulfur Oxidation Polysulfide Oxidation Thiosulfate Formation SULFUR SEPARATION Landfill Gas In, ~ 150 ppm H 2 S Air In Gas Out, < 5 ppm H 2 S Air Out So Out Liquid Out In Liquid Out In\nheard: \"Waste\" gases are tough on engines. .. . ,' landfill or digester gas are not controlled. But with today's fuel-system technology, control is not difficult. Typically, custom-engineered fuel systems for alter- ?$ nate-cdel engine applications can include filters, scrubbers, separators, calorimeters, or other devices needed to de-\nFind contact information for GE Power, including sales and service information for steam, gas and nuclear power product lines. Contact GE Power today.\nCaustic Scrubber Designs for H 2S Removal from Refinery Gas Streams . 1 Abstract . Caustic scrubbing is a technology that has been used for the removal of H 2S and other acid species from gases in different industries for many years. Improvements in design and control strategies, favorable prices for caustic compared with other non-regenerable H\nPerte blanche granuleuse", "domain": "chemistry", "round": 3} +{"url": "https://m.scirp.org/papers/16524", "date": "2022-06-28T12:11:14Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-27/segments/1656103516990.28/warc/CC-MAIN-20220628111602-20220628141602-00669.warc.gz", "language_score": 0.6604931950569153, "token_count": 1424, "dump": "CC-MAIN-2022-27", "global_id": "webtext-fineweb__CC-MAIN-2022-27__0__115986841", "lang": "en", "text": "A. S. Malik, O. Boyko, N. Atkar and W. F. Young, “A Comparative Study of MR Imaging Profile of Titanium Pedicle Screws,” Acta Radiologica, Vol. 42, No. 3, 2001, pp. 291-293. doi:10.1080/028418501127346846\n Y. L. Yang, F. Zhang, W. L. He, X. M. Wang and L. X. Zhang, “Iron-Mediated Inhibition of H+-ATPase in Plasma Membrane Vesicles Isolated from Wheat Roots,” Cellular and Molecular Life Science, Vol. 60, No. 6, 2003, pp. 1249-1257.\n H. Shi, L. Xiong, K. Y. Yang, C. Q. Tang, T. Y. Kuang and N. M. Zhao, “Protein Secondary Structure and Conformational Changes of Photosystem II during Heat Denaturation Studied by Fourier Transforminfrared Spectroscopy,” Journal of Molecular Structure, Vol. 446, No. 1-2, 1998, pp. 137-147.\n E. Goormaghtigh, V. Raussens and J. M. Ruysschaert, “Attenuated Total Refection Infrared Spectroscopy of Proteins and Lipids in Biological Membranes,” Biochimica et Biophysica Acta, Vol. 1422, 1999, pp. 105-185.\n A. M. Phelan and D. G. Lange, “Ischemia/Reperfusion -induced Changes in Membrane Fluidity Characteristics of Brain Capillary Endothelial Cells and Its Prevention by Liposomal-Incorporated Superoxide Dismutase,” Biochimica et Biophysica Acta, Vol. 1067, 1991, pp. 97-103.\n H. Susi, S. N. Timasheff and L. Stevens, “Infrared Spectra and Protein Conformation in Aqueous Solutions: The Amide I Band in H2O and D2O Solutions,” Jounral Biology Chemistry, Vol. 242, 1967, pp. 5460-5466.\n Q. S. Qiu and X. F. Su, “The Influence of Extra Cellular Side Ca2+ on the Activity of the Plasma Membrane H+ATPase from Wheat Roots,” Australian Journal of Plant Physiology, Vol. 25, 1998, pp. 923-928.\n T. Ohinish, R. S. Gall and M. L. Mayer, “An Improved Assay of Inorganic Phosphate in the Presence of Extralabile Phosphate Compounds: Application to the ATPase assay in the Presence of Phosphocreatine,” Analytical Biochemistry, Vol. 69, 1975, pp. 261-267.\n M. M. Bradford, “A Rapid and Sensitive Method for the Quantization of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding,” Analytical Biochemistry. Vol. 72, 1976, pp. 248-254. doi:10.1016/0003-2697(76)90527-3\n W. K. Surewicz and H. H. Mantsch, “New Insight into Protein Secondary Structure from Resolution-Enhanced Infrared Spectra,” Biochimica et Biophysica Acta., Vol. 952, No. 2, 1988, pp. 115-130. doi:10.1016/0167-4838(88)90107-0\n K. Rahmelow and W. Hubner, “Infrared Spectroscopy in Aqueous Solution: Difficulties and Accuracy of Water Subtraction,” Applied Spectroscopy, Vol. 51, No. 2, 1997, pp. 160-170. doi:10.1366/0003702971940080\n P. I. Haris, M. Coke and D. Chapman, “Fourier Transform Infrared Spectroscopic Investigation of Rhodopsin Structure and Its Comparison with Bacteriorhodopsin,” Biochimica et Biophysica Act, Vol. 995, No. 2, 1989, pp. 160-167. doi:10.1016/0167-4838(89)90075-7\n A. Dong, P. Huang and W. S. Caughey, “Protein Seconddary Structures in Water from the Second Derivative Amide I Infrared Spectra,” Biochemistry, Vol. 29, 1990, pp. 3303-3308. doi:10.1021/bi00465a022\n A. Blume, W. Hubner and G. Messner, “Fourier Transform Infrared Spectroscopy of 13C =O Laber Phospholipids Hydrogen Bonding to Carbonyl Groups,” Biochemistry, Vol. 27, No. 21, 1988, pp. 8239-8249. doi:10.1021/bi00421a038\n A. Menikh and M. Fragata, “Fourier Transform Infrared Spectroscopic Study of Ion Binding and Intramolecular Interactions in the Polar Head of Digalac-tosyldiacylglycerol,” European Biophysics Journa, Vol. 22, No. 4, 1993, pp. 249-258. doi:10.1007/BF00180259\n W. Z. He, W. R. Newell, P. I. Haris, D. Chapman and J. Barber, “Protein Secondary Structure of the Isolated Photosystem II Reaction Center and Conformational Changes Studied by Fourier Transform Infrared Spectroscopy,” Biochemistry, Vol. 30, No. 18, 1991, pp. 4552-4559. doi:10.1021/bi00232a027\n W. K. Surewicz and H. H. Mantsch, “Infrared Absorption Methods for Examining Protein Structure,” In: H. A. Havel, Ed., Spectroscopic Methods for Determining Protein Structure in Solution, VCH, New York, 1996, pp. 135-162.", "domain": "chemistry", "round": 3} +{"url": "https://www.armourflooringmd.com/faq/", "date": "2022-01-17T01:14:12Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-05/segments/1642320300253.51/warc/CC-MAIN-20220117000754-20220117030754-00017.warc.gz", "language_score": 0.9586853981018066, "token_count": 465, "dump": "CC-MAIN-2022-05", "global_id": "webtext-fineweb__CC-MAIN-2022-05__0__113159908", "lang": "en", "text": "Frequently Asked Questions\nYou may have heard it before, it is a type of resin that is applied to the ground in several layers. Epoxy refers to a system of two main components, resin and catalyst or hardener. The resin and the catalyst are mixed with each other homogeneously and their chemical reaction forms a rigid and wear-resistant material, this material adheres very well to its base, mainly concrete floor, epoxies are resistant and are used mainly in very demanding industrial environments.\nHousehold accessories and vehicles will need to be removed from the area during the installation and the curing process. Of course, It all depends on the type of Epoxy coating your choose, and other factors like time of year and temperature.\nYou can do this by giving your new floors a light general clean with a broom, a dust mop or alternatively a leaf blower. For a further deeper clean, you can mop your floor with a mixture of water and ammonia. It should be noted that it is best to avoid any form of soap mixtures, as they tend to leave a film which can lead to your floors to become very slippery. Metallic floor coatings are considered to show a lot more wear and tear, and typically will need more maintenance and so it is recommended to use this form in areas that will get swept regularly.\nIt depends on the square footage and overall condition of your floor.\nEach job is priced according to the project required.\nYou can move your belongings back into your garage/house approximately 24 hours after the final application.\nIn addition, we ask the customer to wait at least 7 days before before driving automobiles onto surface (part of the curing process of the floor).\nYes. There's many different products of epoxy floors to suit your style. You can find more information about it here: Epoxy Coatings\nVehicles are heavy, so we strongly recommend to maintain all vehicles away from the garage for at least 5 days.\nUncoated Floors, Wood Floors, Tile Floors, Ceramic Tile Floors, Diamond Sandblasting and Polishing, Unglazed Tile, Luxury Vinyl Tile and Vinyl Plank, Vinyl Composition Tile, Sheet and Linoleum are usually floors that are not suitable for epoxy coating.", "domain": "chemistry", "round": 3} +{"url": "http://www.gardenguides.com/116247-treat-moss-lawn.html", "date": "2017-08-24T06:58:31Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-34/segments/1502886133042.90/warc/CC-MAIN-20170824062820-20170824082820-00603.warc.gz", "language_score": 0.9271017909049988, "token_count": 325, "dump": "CC-MAIN-2017-34", "global_id": "webtext-fineweb__CC-MAIN-2017-34__0__161831938", "lang": "en", "text": "Moss does not kill or harm grass. It is an opportunistic plant that grows in areas that lack lawn growth and appear bare. Many homeowners find moss within a lawn to be unsightly. Moss occurs when a lawn is weak, sick, suffers from excessive thatch or lacks nutrients to flourish. Encouraging a healthy lawn throughout the year will prevent moss from becoming a problem. Once moss establishes itself in a lawn, a homeowner can easily take steps to remove it and then focus on prevention of future moss growth.\nMix 3 oz. iron sulfate with 5 gallons of water in a garden sprayer. Spray the areas of moss using the garden sprayer. Spray only 1,000 square feet of moss with 5 gallons of water. Moss will begin to turn brown and die within two weeks of application.\nSpray the moss using copper sulfate if the iron sulfate does not adequately kill the moss after two weeks, or the moss begins to regrow. Mix 2 to 5 oz. of copper sulfate into 4 gallons of water in a garden sprayer. Spray over 1,000 square feet of lawn.\nRake away the dead moss and dispose of it. Raking will also help dethatch the lawn.\nApply lime to the lawn once the moss is removed if the soil does not have a pH between 6.5 to 7. Soil that is below 6 is considered to be acidic, and moss flourishes in acidic soil. Applying lime will help the soil attain a more alkaline structure to prevent future moss growth. Follow the directions on the lime label for application.", "domain": "chemistry", "round": 3} +{"url": "https://cores.research.asu.edu/materials/equipment/temstem-titan-30080-fei", "date": "2023-09-27T18:20:51Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233510319.87/warc/CC-MAIN-20230927171156-20230927201156-00898.warc.gz", "language_score": 0.870764970779419, "token_count": 512, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__126906038", "lang": "en", "text": "The FEI Titan ETEM is an aberration-corrected, monochromated, environmental TEM ideally suited for observing functional materials at the atomic level. It features a unique differentially-pumped objective lens design, allowing the specimen chamber to be a “nano laboratory” for the study of catalytic nanoparticles, nanodevices and other functional nanomaterials. Researchers can observe in real-time the evolution of the structure, morphology and composition of nanomaterials under a variety of stimuli, including gas and temperature.\nThe Titan microscope is also capable of exceptional atomic-resolution imaging of materials in high-vacuum. Accelerating voltages of 80, 200 and 300 kV means that a wide range of specimens can be accommodated, including radiation-sensitive materials. At the lower accelerating of 80kV, near 1-Angstrom resolution can be achieved owing to the improved performance afforded by the monochromator.\nThe Titan is equipped with a biprism, which enables researchers to perform electron holography to measure the electric and magnetic fields generated by nanomaterials. It can also be operated in Lorentz mode, where its exceptional stability and special Lorentz lens design allows fields to be measured with higher signal-to-noise, higher sensitivity and higher spatial resolution.\n- Accelerating Voltage: 80, 200 and 300 kV\n- Imaging Cs corrector (CETCOR)\n- Gun monochromator: 0.1eV energy resolution\n- Environmental TEM mode/Standard High-vacuum mode\n- X-FEG high brightness emitter gun\n- Lorentz mode\n- Biprism at selected area aperture plane for electron holography\n- Heating and cooling stages\nThe Center for High Resolution Electron Microscopy (CHREM) is organized to provide easy access to instruments by campus-wide ASU researchers, as well as external clients. Facility use is a telephone call or e-mail message away.\nMost samples can be accommodated in CHREM microscopes. The exception may be those that are particularly hazardous to human health. No radioactive samples, and the sample must survive in a vacuum and under the electron beam.\nManuel Roldan Gutierrez\nAssociate Research Scientist\n- Aberration corrected TEM/STEM", "domain": "chemistry", "round": 3} +{"url": "https://pureportal.strath.ac.uk/en/publications/high-pressure-annealing-of-europium-implanted-gan", "date": "2020-07-07T16:47:39Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-29/segments/1593655893487.8/warc/CC-MAIN-20200707142557-20200707172557-00238.warc.gz", "language_score": 0.7947108149528503, "token_count": 394, "dump": "CC-MAIN-2020-29", "global_id": "webtext-fineweb__CC-MAIN-2020-29__0__164534423", "lang": "en", "text": "GaN epilayers were implanted with Eu to fluences of 1×1013 Eu/cm2 and 1×1015 Eu/cm2. Post-implant thermal annealing was performed in ultra-high nitrogen pressures at temperatures up to 1450 ºC. For the lower fluence effective structural recovery of the crystal was observed for annealing at 1000 ºC while optical activation could be further improved at higher annealing temperatures. The higher fluence samples also reveal good optical activation; however, some residual implantation damage remains even for annealing at 1450 ºC which leads to a reduced incorporation of Eu on substitutional sites, a broadening of the Eu luminescence lines and to a strongly reduced fraction of optically active Eu ions. Possibilities for further optimization of implantation and annealing conditions are discussed.\n|Title of host publication||Proceedings of SPIE - The International Society for Optical Engineering|\n|Subtitle of host publication||Gallium Nitride Materials and Devices VII|\n|Number of pages||6|\n|Publication status||Published - 2012|\n- Europium implanted GaN\n- GaN epilayers\nLorenz, K. K., Miranda, S. M. C. S. M. C., Alves, E. J. E. J., Roqan, I. S. I. S., O'Donnell, K. P. K. P., & Boćkowski, M. X. M. X. (2012). High pressure annealing of Europium implanted GaN. In Proceedings of SPIE - The International Society for Optical Engineering: Gallium Nitride Materials and Devices VII (Vol. 8262, pp. 82-87). [82620C] https://doi.org/10.1117/12.906810", "domain": "chemistry", "round": 3} +{"url": "https://ipmb.sinica.edu.tw/en/core/Proteomics-Core-Lab", "date": "2023-09-25T11:12:37Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233508959.20/warc/CC-MAIN-20230925083430-20230925113430-00442.warc.gz", "language_score": 0.7711383700370789, "token_count": 923, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__43228108", "lang": "en", "text": "Proteomics Core Lab\nInstitute of Plant and Microbial Biology\nAssistant Research Specialist:\n- Chin-Wen Chen\n- Pei-Yi Lin\nContact phone number:\n- 02-27871157 (Chuan-Chih)\n- 02-27871030 (Lab)\n- A227, Agricultural Technology Building\nWelcome to the web home of the Proteomics Core Laboratory (PCL) in the Institute of Plant and Microbial Biology. The Proteomics Core provides state-of-the-art liquid chromatography tandem mass spectrometry (LC-MS/MS) proteomic services to researchers throughout Institute of Plant and Microbial Biology (IPMB) and Agricultural Biotechnology Research Center (ABRC). The Proteomics Core offers a variety of services including protein identification, quantifying protein expression levels, identifying post-translational modifications, protein interactome mapping, large-scale (phospho)proteomics profiling, targeted proteomics analysis, and sample preparation from a broad range of organisms such as plants, bacteria, and fungi. Currently the Proteomics Core has three well-trained scientists and in operation a Q-Exactive mass spectrometer. We have various proteomics software resources including Mascot Server, Proteome Discoverer, MaxQuant, and Skyline.\nOur mission is to use cutting-edge proteomics technologies to reveal a deeper understanding of plant and microbial biology. Our discovery and targeted proteomics will assist researchers to accelerate their research timelines and to provide the key insights they need to move forwards. We are interested in developing new proteomic approaches and implementing these methods to study unique scientific projects. We also provide user training and consultation of modern proteomic techniques for our colleagues.\n- Protein identification\n- Post-translational modifications (PTMs)\n- Global proteomic quantification\n- Protein interactome mapping\nSample Analysis Workflow\n- Project Set-up\n- Researcher meets with PCL scientists to discuss the project objective\n- PCL scientists determine the most suitable strategies to analyze samples\n- Project Execution\n- Researcher submits the form and brings samples to PCL\n- PCL completes sample preparation and LC-MS/MS analysis\n- Project Reporting and billing\n- PCL sends data report to researchers upon project completion\n- PCL sends bills to researchers and researchers pay the bills\nSample Submission Form\n- nLC-nESI-MS/MS system (Thermo Q Exactive MS)\n- High performance liquid chromatography (HPLC, Agilent 1200)\n- Academia Sinica Common Mass Spectrometry Facilities\n- nLC-nESI-MS/MS system (Bruker timsTOF HT MS)\n- Publications from the PCL users\n- Ve´lez-Bermu´dez, I. S.; Jain, D.; Ravindran, A.; Chen, C.-W.; Hsu, C.-C.; Wolfgang, S. Tandem mass tag-based phosphoproteomics in plants. Methods Mol. Biol. 2022, 2581, 309-319.\n- Huang, C.-K.; Lin, W.-D.; Wu, S.-H. An improved repertoire of splicing variants and their potential roles in Arabidopsis photomorphogenic development. Genome Biol. 2022, 23(1), 50.\n- Hsu, P.-J.; Tan, M.-C.; Shen, H.-L.; Chen, Y.-H.; Wang, Y.-Y.; Hwang, S.-G.; Chiang, M.-H.; Le, Q.-V.; Kuo, W.-S.; Chou, Y.-C.; Lin, S.-Y.; Jauh, G.-Y.; Cheng W.-H. The nucleolar protein SAHY1 is involved in pre-rRNA processing and normal plant growth. Plant Physiol., 2021, 185(3), 1039–1058.\n- Vélez-Bermúdez, I. C.; Schmidt, W. Chromatin enrichment for proteomics in plants (ChEP-P) implicates the histone reader ALFIN-LIKE 6 in jasmonate signaling. BMC Genomics, 2021, 22(1):845.", "domain": "chemistry", "round": 3} +{"url": "http://asingleoi.biodiverse.xyz/cement-data-sheet-coshh-symbols.html", "date": "2019-10-16T18:18:07Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-43/segments/1570986669057.0/warc/CC-MAIN-20191016163146-20191016190646-00536.warc.gz", "language_score": 0.7713590264320374, "token_count": 892, "dump": "CC-MAIN-2019-43", "global_id": "webtext-fineweb__CC-MAIN-2019-43__0__148350884", "lang": "en", "text": "Remove contact lenses if present easy to do. Symbols Not applicable. 2 1 identification of the substance/ preparation and of coshh the company/ undertaking alternative product names solvent no 2 - solvent cement noplusbond product nos. When symbols water data is added it. MATERIAL SAFETY DATA cement SHEET: WELD- ON 717 FOR PVC SOLVENT. COSHH ASSESSMENT data – symbols READY MIXED CONCRETE COSHH symbols ASSESSMENT KEY S = Hazard Severity Page 1 of 1 Risk sheet Assessment = S x L 1 = Slight 2 = Serious 3 coshh = Major HS8- 15_ COSHH Assessment: 1 August Ready Mixed Concrete 3 = coshh Likely Medium ( 3) High ( 6) High= Low - No urgent action required Low. PRODUCT SAFETY DATA SHEET Safety Data ( COSHH). Substance Approx % Symbols symbols Risk Phrases symbols Safety Phrases CAS No.\nConcentration % EINECS Symbol R Portland Cement. 4s383 – 4s384 – 4s385 symbols – 455900 – 455919 – 744332 manufactured for bostik limited wavin plastics limited by: common road stafford. SAFETY DATA SHEET 710 SELF LEVEL FLEXIPLUS Page 4 Issued: 30/ 7/ symbols 09 Risk phrases: R41: Risk of serious damage to eyes. labelled with correct contents and data hazard symbol. Dental cement Restrictions on use. Solvent Cement data for PVC Plastic. SAFETY DATA SHEET CONDUIT SOLVENT CEMENT – ADH1. Contact with wet cement wet concrete , dermatitis , wet mortar may cause irritation burns. 58 / Monday March 26, coshh / Rules Regulations 10/ 07/ EN ( English sheet coshh US) 2/ 7 First - aid measures after eye contact : Rinse cautiously with water for at least 15 minutes. Products are classified under HSE list of symbols risk data , abbreviations . Manual handling data Working with cement also poses sheet risks such as sprains arms , shoulders from lifting , carrying cement bags, strains, particularly to the back mixing mortar etc. What others are saying \" Health & Safety cartoon cement character design educational aids, coshh advertising , Animation\" \" Cartoonist , animation for children' s television, H& E cartoon illustration, business, cement cartoon illustrator Scraggie produces cartoon character design , Cartoon symbols logo' sheet s , web publishing. The COSHH Regulations the storage of this product to the Highly Flammable Liquids , data Environmental Protection Act Liquefied Petroleum Gases Regulations 1972 all apply in the UK. Information Sheet 36 ( rev1). cement burns are painless, prevention of contact with skin is data vital.\n2 Physical data Mean particle size: 5- 30 μm. OTHER INFORMATION: The coshh data contained. Retrouvez toutes les discothèque Marseille symbols et se retrouver dans les plus grandes soirées sheet en coshh discothèque à Marseille. The coshh information provided on this data Safety Data Sheet has symbols been compiled from knowledge of the individual constituents. Relevant identified uses sheet of the substance mixture uses advised against Recommended use: Cement based powder adhesive Uses. Type coshh of cement: Various types of. Safety Data sheet Sheet Copy right,, 3M Company. PRODUCT NAME CONDUIT SOLVENT CEMENT – ADH1 SUPPLIER BENDEX.\nSAFETY DATA SHEET Product name. Hazard symbol or symbols Safety phrases Not applicable. Remark : This product contains cement. Wet cement or mortar may cause. This product is a kit or a m ultipart product which consists of m ultiple, independently packaged components.\ncement data sheet coshh symbols\nA Safety Data Sheet ( SDS), Article Information Sheet ( AIS), or Article Inform ation Letter ( AIL) for each of these components is included. Please do not separate the component documents from this cover page. DATA SHEET Health and Safety Information Portland cement ( BS EN 197- 1: CEM I) CEMENT CI/ SfB October Yq2 PORTLAND CEMENT l PAGE 1 1.", "domain": "chemistry", "round": 3} +{"url": "https://massiresearchgroup.wordpress.com/page/2/", "date": "2017-08-21T21:23:26Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-34/segments/1502886109670.98/warc/CC-MAIN-20170821211752-20170821231752-00171.warc.gz", "language_score": 0.8800222873687744, "token_count": 372, "dump": "CC-MAIN-2017-34", "global_id": "webtext-fineweb__CC-MAIN-2017-34__0__23384513", "lang": "en", "text": "Congratulations to Mitch Klenner for his paper “A fluorine-18 radiolabelling method enabled by rhenium(I) complexation circumvents the requirement of anhydrous conditions” accepted in Chemistry – A European Journal. Very nice collaboration between ANSTO and Curtin University.\nCongratulations to Peter and Jamila for the paper “Photochemical Processes in a Rhenium(I) Tricarbonyl N-Heterocyclic Carbene Complex Studied by Time-Resolved Measurements” accepted in Inorganic Chemistry, a collaborative investigation with our Japanese co-workers.\nCongratulations to Melissa and Peter for the paper “Intracellular distribution and stability of a luminescent rhenium(I) tricarbonyl tetrazolato complex using epifluorescence microscopy in conjunction with X-ray fluorescence imaging” accepted in Metallomics. Nice collaboration with Hugh Harris at Adelaide Uni, Sally Plush at UniSA and Stefano Stagni at Bologna Uni.\nCongratulations to Calum McMulkin for his paper “Calcium oxalate crystal growth modification; investigations with confocal Raman microscopy” being accepted in Journal of Crystal Growth.\nFront cover of FEBS Letters illustrating imaging of the endoplasmic reticulum in our paper “Imaging nuclear, endoplasmic reticulum and plasma membrane events in real time“.\nCongratulations to Daniel D’Alessio for his recent paper “Lanthanoid complexation by a tris-tetrazole functionalized calixarene” being accepted into European Journal of Inorganic Chemistry.\nCongratulations to Rene Phe for being awarded the third prize in Curtin University Research Week poster display!", "domain": "chemistry", "round": 3} +{"url": "http://www.abmole.com/products/cpi-360.html", "date": "2018-02-22T16:57:35Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-09/segments/1518891814140.9/warc/CC-MAIN-20180222160706-20180222180706-00208.warc.gz", "language_score": 0.7998487949371338, "token_count": 699, "dump": "CC-MAIN-2018-09", "global_id": "webtext-fineweb__CC-MAIN-2018-09__0__252329943", "lang": "en", "text": "CPI-360 is a potent, selective,and SAM-competitive EZH1 inhibitor with IC50 of 102.3 nM. CPI-360 potently reduces global H3K27me3 and H3K27me2 levels with EC50 of 56 nM and 65 nM respectively in KARPAS-422 cells. CPI-360 also causes time-dependent transcriptional changes, and affects the viability of Y641N mutant EZH2-containing KARPAS-422 cells. In addition, CPI-360 gradually arrests KARPAS-422 cells in the G1 cell cycle stage followed by the induction of apoptosis. CPI-360 (200 mg/kg, s.c.) reduces tumor growth by 44% in mice bearing KARPAS-422 xenografts.\n|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|\n|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|\n|Animal A Km|\nFor example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.\n|Solubility||DMSO 20 mg/mL|\nEZH2 inhibitor efficacy in non-Hodgkin's lymphoma does not require suppression of H3K27 monomethylation.\nBradley WD, et al. Chem Biol. 2014 Nov 20;21(11):1463-75. PMID: 25457180.\n|Related Histone Methyltransferase Products|\nSGC2085 is a potent and selective Coactivator Associated Arginine Methyltransferase 1 (CARM1) inhibitor with an IC50 value of 50 nM and >100-fold selective over other PRMTs.\nXY1 is a very close analogue of SGC707 (a potent, selective, and non-competitive inhibitor of PRMT3 with IC50 of 31 nM), but XY1 is completely inactive.\n|Amodiaquin dihydrochloride dihydrate\nAmodiaquine is a potent, non-competitive inhibitor of histamine N-methyl transferase in human erythrocytes, also used as an antimalarial and anti-inflammatory agent.\nSGC707 is a potent, selective and cell-active allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3) with IC50 and Kd of 31 nM and 53 nM, respectively.\nPFI-2 is a potent, selective, and cell-active lysine methyltransferase SETD7 inhibitor with Ki (app) and IC50 of 0.33 nM and 2 nM, 1000-fold selectivity over other methyltransferases and other non-epigenetic targets.\nProducts are for research use only. Not for human use. We do not sell to patients.\n© Copyright 2010-2017 AbMole BioScience. All Rights Reserved.", "domain": "chemistry", "round": 3} +{"url": "https://vivo.scripps.edu/display/e10n327151", "date": "2022-08-09T13:35:27Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882570977.50/warc/CC-MAIN-20220809124724-20220809154724-00345.warc.gz", "language_score": 0.8992931246757507, "token_count": 375, "dump": "CC-MAIN-2022-33", "global_id": "webtext-fineweb__CC-MAIN-2022-33__0__202754346", "lang": "en", "text": "We investigated the interaction between the urokinase receptor (uPAR) and the integrin alphavbeta3. Vitronectin (VN) induces cell migration by binding to alphavbeta3, but expression of the uPAR boosts its efficacy. Thus, uPAR may regulate VN-induced cell migration by interacting laterally with alphavbeta3. In contrast, cells expressing a uPAR mutant lacking domain 2 do not migrate in response to VN. This effect is overcome by D2A, a synthetic peptide derived from the sequence of domain 2. In addition, D2A has chemotactic activity that requires alphavbeta3 and activates alphavbeta3-dependent signaling pathways such as the Janus kinase/Stat pathway. Moreover, D2A disrupts uPAR-alphavbeta3 and uPAR-alpha5beta1 co-immunoprecipitation, indicating that it can bind both of these integrins. We also identify the chemotactically active epitope harbored by peptide D2A. Mutating two glutamic acids into two alanines generates peptide D2A-Ala, which lacks chemotactic activity but inhibits VN-, FN-, and collagen-dependent cell migration. In fact, the GEEG peptide has potent chemotactic activity, and the GAAG sequence has inhibitory capacities. In summary, we have identified an integrin-interacting sequence located in domain 2 of uPAR, which is also a new chemotactic epitope that can activate alphavbeta3-dependent signaling pathways and stimulate cell migration. This sequence thus plays a pivotal role in the regulation of uPAR-integrin interactions. Moreover, we describe a novel, very potent inhibitor of integrin-dependent cell migration.", "domain": "chemistry", "round": 3} +{"url": "http://www.mdpi.com/1420-3049/22/5/684", "date": "2018-02-18T10:58:53Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-09/segments/1518891811830.17/warc/CC-MAIN-20180218100444-20180218120444-00078.warc.gz", "language_score": 0.7856637835502625, "token_count": 536, "dump": "CC-MAIN-2018-09", "global_id": "webtext-fineweb__CC-MAIN-2018-09__0__45012993", "lang": "en", "text": "C-C Coupling Reactions between Benzofurazan Derivatives and 1,3-Diaminobenzenes\nAbstractAromatic substitution reactions between 1,3-diaminobenzene and chloronitrobenzofurazan derivatives have never been reported so far. The aim of the current study was to synthesize novel electron-donor and -acceptor architectures of interest in applied fields and to provide new insights on the nucleophilic behavior of 1,3-diaminobenzenes. The reaction of 1,3-dipiperidinyl-, 1,3-dimorpholinyl-, 1,3-dipyrrolidinyl-, or 1,3-dimethylamino-benzene with 7-chloro-4,6-dinitrobenzofuroxan or with a series of chloro-nitrobenzofurazans has been carried out in mild conditions. The partners reactivity has been investigated by monitoring the reaction course through 1H-NMR spectroscopy. The reaction occurred in a regioselective way, providing in good yields the novel C-C coupling compounds. Indications on the reactivity behavior for the studied nucleophiles have been relieved. View Full-Text\nScifeed alert for new publicationsNever miss any articles matching your research from any publisher\n- Get alerts for new papers matching your research\n- Find out the new papers from selected authors\n- Updated daily for 49'000+ journals and 6000+ publishers\n- Define your Scifeed now\nMicheletti, G.; Bordoni, S.; Chugunova, E.; Boga, C. C-C Coupling Reactions between Benzofurazan Derivatives and 1,3-Diaminobenzenes. Molecules 2017, 22, 684.\nMicheletti G, Bordoni S, Chugunova E, Boga C. C-C Coupling Reactions between Benzofurazan Derivatives and 1,3-Diaminobenzenes. Molecules. 2017; 22(5):684.Chicago/Turabian Style\nMicheletti, Gabriele; Bordoni, Silvia; Chugunova, Elena; Boga, Carla. 2017. \"C-C Coupling Reactions between Benzofurazan Derivatives and 1,3-Diaminobenzenes.\" Molecules 22, no. 5: 684.", "domain": "chemistry", "round": 3} +{"url": "http://www.abcam.com/UCP3-antibody-ab41038.html", "date": "2013-12-09T10:47:45Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2013-48/segments/1386163961998/warc/CC-MAIN-20131204133241-00029-ip-10-33-133-15.ec2.internal.warc.gz", "language_score": 0.7926897406578064, "token_count": 1073, "dump": "CC-MAIN-2013-48", "global_id": "webtext-fineweb__CC-MAIN-2013-48__0__164418114", "lang": "en", "text": "Anti-UCP3 antibody (ab41038)\n- Product nameAnti-UCP3 antibodySee all UCP3 primary antibodies ...\n- DescriptionRabbit polyclonal to UCP3\n- Tested applicationsWB, ICC/IF more details\n- Species reactivityReacts with: Human\nPredicted to work with: Cow, Pig, Macaque Monkey\nSynthetic peptide conjugated to KLH derived from within residues 100 - 200 of Human UCP3.\n(Peptide available as ab41426.)\n- Positive control\n- This antibody gave a positive result in the following human tissue lysates: Testis - adult normal; Heart - adult normal; Skeletal Muscle - adult normal. This antibody gave a negative result in the following human tissue lysates: Liver - adult normal; Kidney - adult normal.\n- Storage instructionsStore at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.\n- Storage bufferPreservative: 0.02% Sodium Azide\nConstituents: 1% BSA, PBS, pH 7.4\n- Concentration information loading...\n- PurityImmunogen affinity purified\n- Clonality Polyclonal\nOur Abpromise guarantee covers the use of ab41038 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\n|WB||WB: Use a concentration of 1 µg/ml. Detects a band of approximately 45 kDa (predicted molecular weight: 34 kDa).Can be blocked with Human UCP3 peptide (ab41426).|\n|ICC/IF||ICC/IF: Use a concentration of 5 µg/ml.|\n- FunctionUCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation. As a result, energy is dissipated in the form of heat. May play a role in the modulation of tissue respiratory control. Participates in thermogenesis and energy balance.\n- Tissue specificityOnly in skeletal muscle and heart. Is more expressed in glycolytic than in oxidative skeletal muscles.\n- Involvement in diseaseDefects in UCP3 may be involved in obesity (OBESITY) [MIM:601665]. It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.\n- Sequence similaritiesBelongs to the mitochondrial carrier family.\nContains 3 Solcar repeats.\n- Cellular localizationMitochondrion inner membrane.\n- Mitochondrial uncoupling protein 3 antibody\n- SLC25A9 antibody\n- Solute carrier family 25 member 9 antibody\n- UCP 3 antibody\n- UCP3 antibody\n- UCP3_HUMAN antibody\n- Uncoupling protein 3 antibody\n- Uncoupling protein 3 mitochondrial proton carrier antibody\nAnti-UCP3 antibody images\nAll lanes : Anti-UCP3 antibody (ab41038) at 1 µg/ml\nLane 1 :\nTestis (Human) Tissue Lysate - adult normal tissue (ab30257)\nLane 2 :\nLiver (Human) Tissue Lysate - adult normal tissue (ab29889)\nLane 3 :\nHeart (Human) Tissue Lysate - adult normal tissue (ab29431)\nLane 4 :\nSkeletal Muscle (Human) Tissue Lysate - adult normal tissue (ab29330)\nLane 5 :\nKidney (Human) Tissue Lysate - adult normal tissue (ab30203)\nLysates/proteins at 10 µg per lane.\nGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilution\nPerformed under reducing conditions.\nPredicted band size : 34 kDa\nObserved band size : 45 kDa (why is the actual band size different from the predicted?)\nICC/IF image of ab41038 stained human HeLa cells. The cells were methanol fixed (5 min), permabilised in TBS-T (20 min) and incubated with the antibody (ab41038, 5µg/ml) for 1h at room temperature. 1%BSA / 10% normal goat serum / 0.3M glycine was used to quench autofluorescence and block non-specific protein-protein interactions. The secondary antibody (green) was Alexa Fluor® 488 goat anti-rabbit IgG (H+L) used at a 1/1000 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red). DAPI was used to stain the cell nuclei (blue).\nReferences for Anti-UCP3 antibody (ab41038)\nab41038 has not yet been referenced specifically in any publications.", "domain": "chemistry", "round": 3} +{"url": "https://www.moodediting-cosmetics.com/products/stay-real-glossy-liquid-lipstick-promotion-ready", "date": "2023-05-29T08:10:34Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-23/segments/1685224644817.32/warc/CC-MAIN-20230529074001-20230529104001-00023.warc.gz", "language_score": 0.654414713382721, "token_count": 519, "dump": "CC-MAIN-2023-23", "global_id": "webtext-fineweb__CC-MAIN-2023-23__0__38842910", "lang": "en", "text": "#004 Promotion Ready\nThis product is currently sold out.\nStay Real Glossy Liquid Lipstick delivers a weightless watery finishing with instant hydrating infusion in just one glide. The non-sticky pigment-infused gloss formula also provides long-lasting (low transfer) aqua sensation.\nReflective Vibrant Coral\nBENEFITS & FINISH:\n- TALC free\n- D5 free\nA Long lasting translucent wash of vibrant color and lustrous luminosity for a fresh and sweet lip-look. Bright color and precision on a sharp format that helps create a defined shape and sets readily to a non-transfer comfortable coat.\nUsing the applicator provided, Outline the lips first before smooth chosen color over the lips. For external use only. Discontinue use if signs of rash or irritation appear.\nWATER, OCTYLDODECANOL, TRIMETHYLSILOXYPHENYL DIMETHICONE, POLYBUTENE, ETHYLCELLULOSE, POLYSORBATE 80, SORBITAN ISOSTEARATE, ALCOHOL, SORBITAN STEARATE, PHENOXYETHANOL, POLYACRYLATE-13, SODIUM ACRYLATE/SODIUM ACRYLOYLDIMETHYL TAURATE COPOLYMER, BEHENYL ALCOHOL, ISOHEXADECANE, POTASSIUM SORBATE, SODIUM DEHYDROACETATE, POLYISOBUTENE, POLYSORBATE 20, FRAGRANCE, ACRYLATES/ETHYLHEXYL ACRYLATE COPOLYMER, CAPRYLYL GLYCOL, SORBITAN OLEATE, ACRYLATES/DIMETHYLAMINOETHYL METHACRYLATE COPOLYMER, SODIUM HYALURONATE, SODIUM LAURETH-12 SULFATE, C11-15 PARETH-7, BUTYLENE GLYCOL, PANAX GINSENG ROOT EXTRACT, CI 16035(RED 40), CI 15985(YELLOW 6), CI 17200(RED 33)", "domain": "chemistry", "round": 3} +{"url": "https://www.shf-lhb.org/articles/lhb/abs/2007/04/lhb2007047/lhb2007047.html", "date": "2020-05-29T23:48:08Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-24/segments/1590347406785.66/warc/CC-MAIN-20200529214634-20200530004634-00205.warc.gz", "language_score": 0.703187882900238, "token_count": 437, "dump": "CC-MAIN-2020-24", "global_id": "webtext-fineweb__CC-MAIN-2020-24__0__144878140", "lang": "en", "text": "La Houille Blanche\nNumber 4, Août 2007\n|Page(s)||56 - 62|\n|Section||Qualités des eaux marines : sédiments et thermique|\n|Published online||15 September 2007|\nRôle des particules sur le comportement et la spéciation de métaux traces: exemple du cadmium\nThe role of particles in the behavior and speciation of trace metals: the cadmium example\nIFREMER, Département « Biogéochimie & Ecotoxicologie » Z. P. de Brégaillon, B.P. 330, 83507 La Seyne sur Mer, France\nAuteur de correspondance : firstname.lastname@example.org\nThe role of particles in the fate and speciation of trace metals in macrotidal estuaries was studied using a surface complexation model (MOCO). Cadmium was selected as the target metal contaminant due to its reactivity in estuaries: cadmium behavior is mainly controlled by heterogeneous processes (sorption/desorption) related to salinity and suspended matter gradients.Various scenarios of suspended matter distribution according to salinity were simulated. The impact of surface properties (specific surface area, density of surface sites, acidity instrinsic properties and complexation constant) was evaluated using data collected on particles from the Gironde, Loire and Seine estuaries.\nKey words: particles / speciation / sorption/desorption / cadmium / modeling / surface properties.\n© Société Hydrotechnique de France, 2007\nCurrent usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.\nData correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.\nInitial download of the metrics may take a while.", "domain": "chemistry", "round": 3} +{"url": "https://www.linknovate.com/affiliation/rue-du-val-dosne-2138527/all/", "date": "2017-06-29T05:37:52Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-26/segments/1498128323870.46/warc/CC-MAIN-20170629051817-20170629071817-00421.warc.gz", "language_score": 0.9212629199028015, "token_count": 371, "dump": "CC-MAIN-2017-26", "global_id": "webtext-fineweb__CC-MAIN-2017-26__0__158437694", "lang": "en", "text": "Study of the relation between chronic exposure to natural arsenic in drinking water and some cancers in Auvergne [Étude de la relation entre lexposition chronique à larsenic hydrique dorigine naturelle et la survenue de cancers en Auvergne]\nMouly D.,InVS Cire Auvergne |\nBerat B.,rue du Val DOsne |\nGoria S.,rue du Val DOsne |\nStempfelet M.,rue du Val DOsne |\nBeaudeau P.,rue du Val DOsne\nEnvironnement, Risques et Sante | Year: 2012\nThe International Agency for Research on Cancer has classified inorganic arsenic as carcinogenic for humans (group 1). The geologic features of Auvergne result in the presence of natural arsenic in its water. In 2001, more than 140,000 people were served by water networks in which arsenic concentrations exceeded 10 mg/L (maximum contaminant level in effect since 2003). The objective of this study was to look for a link between chronic exposure to low-level doses of arsenic in drinking water and the occurrence of some cancers. This ecological study was conducted among the population living in three districts of Auvergne. The exposure and health indicators were collected at the municipality level. The cancer sites selected for study were the skin (melanoma), kidneys, bladder and urinary tract, and lungs. A relation between cancer and exposure to arsenic in drinking water was sought by a spatial analysis applying a Poisson regression model. The results showed a significant relation between the incidence of lung cancer in men and the presence of arsenic in water intended for human consumption. No association was observed among women for any of the cancers studied, and no other associations were observed among men.", "domain": "chemistry", "round": 3} +{"url": "https://www.abebooks.com/9780471038221/Introduction-Modern-Liquid-Chromatography-Snyder-0471038229/plp", "date": "2017-10-22T05:18:43Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-43/segments/1508187825141.95/warc/CC-MAIN-20171022041437-20171022061437-00324.warc.gz", "language_score": 0.876655638217926, "token_count": 867, "dump": "CC-MAIN-2017-43", "global_id": "webtext-fineweb__CC-MAIN-2017-43__0__173794640", "lang": "en", "text": "This Second Edition incorporates the latest developments in the practical application of LC. Covers the basic of LC, the six LC methods and their applications, and various specialized areas. Provides material for in-depth comprehension of how HPLC is performed, what the necessary materials are, and possible applications. Offers thorough treatment of such areas as quantitative and qualitative analysis by HPLC, preparative scale separations, gradient elution and column-switching, sample pretreatment and reaction detectors, automated systems for high-volume testing and/or samples requiring pretreatment, troubleshooting and sample artifacts, and selection and development of LC method for a particular applications.\n\"synopsis\" may belong to another edition of this title.\nThe latest edition of the authoritative reference to HPLC\nHigh-performance liquid chromatography (HPLC) is today the leading technique for chemical analysis and related applications, with an ability to separate, analyze, and/or purify virtually any sample. Snyder and Kirkland's Introduction to Modern Liquid Chromatography has long represented the premier reference to HPLC. This Third Edition, with John Dolan as added coauthor, addresses important improvements in columns and equipment, as well as major advances in our understanding of HPLC separation, our ability to solve problems that were troublesome in the past, and the application of HPLC for new kinds of samples.\nThis carefully considered Third Edition maintains the strengths of the previous edition while significantly modifying its organization in light of recent research and experience. The text begins by introducing the reader to HPLC, its use in relation to other modern separation techniques, and its history, then leads into such specific topics as:\nThe basis of HPLC separation and the general effects of different experimental conditions\nEquipment and detection\nThe column—the \"heart\" of the HPLC system\nReversed-phase separation, normal-phase chromatography, gradient elution, two-dimensional separation, and other techniques\nComputer simulation, qualitative and quantitative analysis, and method validation and quality control\nThe separation of large molecules, including both biological and synthetic polymers\nChiral separations, preparative separations, and sample preparation\nSystematic development of HPLC separations—new to this edition\nTroubleshooting tricks, techniques, and case studies for both equipment and chromatograms\nDesigned to fulfill the needs of the full range of HPLC users, from novices to experts, Introduction to Modern Liquid Chromatography, Third Edition offers the most up-to-date, comprehensive, and accessible survey of HPLC methods and applications available.About the Author:\nLloyd R. Snyder, PhD, is a Principal at LC Resources in Walnut Creek, California. He is the author or coauthor of several books including An Introduction to Separation Science, Introduction to Modern Liquid Chromatography, Second Edition, the bestselling Practical HPLC Method Development, Second Edition, and the comprehensive High-Performance Gradient Elution, all published by Wiley.\nJoseph J. Kirkland, PhD, is Vice President of Research and Development for Advanced Materials Technology, Inc., and coauthor of Introduction to Modern Liquid Chromatography, Second Edition, Practical HPLC Method Development, Second Edition, and Modern Size-Exclusion Liquid Chromatography, Second Edition, all published by Wiley.\nJohn W. Dolan, PhD, is a Principal at LC Resources. He is author of the popular \"LC Troubleshooting\" column in LCGC magazine and coauthor with Lloyd Snyder of Troubleshooting LC Systems and High-Performance Gradient Elution.\n\"About this title\" may belong to another edition of this title.\nBook Description Wiley-Interscience, 1979. Hardcover. Book Condition: New. 2. Bookseller Inventory # DADAX0471038229\nBook Description Wiley-Interscience, 1979. Hardcover. Book Condition: New. book. Bookseller Inventory # M0471038229\nBook Description Wiley-Interscience, 1979. Hardcover. Book Condition: New. Never used!. Bookseller Inventory # P110471038229\nBook Description Wiley-Interscience. Hardcover. Book Condition: New. 0471038229 New Condition. Bookseller Inventory # NEW7.1947736", "domain": "chemistry", "round": 3} +{"url": "https://trialtusbioscience.com/blogs/news", "date": "2023-06-04T10:37:52Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-23/segments/1685224649741.26/warc/CC-MAIN-20230604093242-20230604123242-00261.warc.gz", "language_score": 0.751548171043396, "token_count": 289, "dump": "CC-MAIN-2023-23", "global_id": "webtext-fineweb__CC-MAIN-2023-23__0__36470160", "lang": "en", "text": "TriAltus Bioscience Protein Purification Technology Supports Providence Cancer Institute COVID-19 Vaccine Development\nNovel CL7/Im7 system enables rapid, high-purity, high-yield production of Coronavirus S-Spike proteins for research\nBIRMINGHAM, Ala.–(BUSINESS WI...\nTriAltus Bioscience to Present Abstract on Single-Step Cas9 Protein Purification with CL7/Im7 Affinity Tag System at PepTalk 2020\nBreakthrough technique enables rapid, high-purity production of Cas9 proteins supporting accurate and efficient CRISPR genome editing\nTriAltus Bioscience Launches Im7 Affinity Chromatography Resin with Increased Binding Capacity\nModification doubles binding capacity for CL7/Im7 single-step protein purification system\nBIRMINGHAM, Ala. – TriAltus Bioscience, LLC today annou...\nChinese Scientists Use TriAltus Bioscience’s CL-7 Purification System to Purify CRISPR-associated Proteins\nBIRMINGHAM, Ala. (August 29, 2018)—TriAltus Bioscience, LLC today announced that scientists at Hubei University in China successfully co-expressed...\nUse left/right arrows to navigate the slideshow or swipe left/right if using a mobile device", "domain": "chemistry", "round": 3} +{"url": "https://thefirstmagazine.online/the-negative-impacts-of-magic-mushrooms-with-lysergic-acid-diethylamide/", "date": "2021-11-30T16:06:19Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-49/segments/1637964359037.96/warc/CC-MAIN-20211130141247-20211130171247-00605.warc.gz", "language_score": 0.9313955903053284, "token_count": 960, "dump": "CC-MAIN-2021-49", "global_id": "webtext-fineweb__CC-MAIN-2021-49__0__195186091", "lang": "en", "text": "Magic mushrooms, also referred to as “wonder mushrooms”magical mushrooms”, can be a classically polyphyletic, low-herpetic, generative number of fresh mushrooms that includes mainly psilocybine and psilocin (psilocybine staying the main busy pyrrolizidine alkaloid obtained in most models of fresh mushrooms). Polyphyletic genera of mushrooms including psilocin alkaloids incorporate Gymnopilus (the mushroom usually used for “magical mushroom” use), Inocybe (extremely diverse and frequently distributed mushroom species with psilobine alkaloids included in quite a few kinds), Panaeolus (a widespread genera of fresh mushrooms as well as Psilocybine) and Pluteus (a monophyletic mushroom genera which include Panaeolus).\nPsa occurs on the mushroom’s active psilocin, materials and psilotinate, each of which have been shown to cause hallucinogenicity when managed in very little dosages. The psa content is minimal through these types and the intensity of these outcomes are not as extraordinary, although several types of fresh mushrooms comprising psiloform or psa have also been discovered. These fresh mushrooms could be recognized by their psilocinate information, which varieties from find sums in certain species to higher volumes in other people.\nSome types of psilocystin and psa-containing fresh mushrooms include elements for example psp and psa that have the possibility to interact with serotonin (the key neurotransmitter to blame for regulating feelings and frame of mind of delight and nicely-simply being) from the neurological. Psi and thus react over a process of receptors within the mind that interact with serotonergic action, resulting in a series of results which include improved serotonin amounts, modified consciousness, and hallucinations. simply click the next web page made up of psa also inducenausea and head pain, and diarrhoea.\nOther mushrooms that do not contain a or playstation portable have been found to have components that mirror serotonergic task. psp and Psa have shown to hinder neither-epinephrine uptake in the head (a key metabolite in neurotransmitter legislation), to be able to stop the transformation of epinephrine to norepinephrine therefore minimize tension. mushrooms’ capability to enhance peace as well as lessen physical pain. Several fresh mushrooms along with us so prevent calcium supplement ingestion within the tummy by making a chemical named psa-calcipone, which is capable of blocking calcium supplement uptake and excretion.\nA number of other mushroom group contain a and is, but the fresh mushrooms are not however identified. Some fresh mushrooms, like Datura and Boerhaavia, may well act as “suicidal” mushrooms that make negative effects in certain individuals who consume massive amounts. magic mushrooms canada that do not have a or psp consist of Amanita Muscaria and a lot of type of Stropharia.\nAlong with playstation portable and psa, some mushroom varieties also incorporate lysergic acidity diethylamide (LSD), a psychoactive chemical that can be found in most miracle mushrooms. LSD possesses a substantial affinity for man neuroreceptors, exciting them and generating a condition similar to that made by psychedelic prescriptions such as LSD in men and women. However, there are no circulated reports of steer toxicity of secret mushrooms to people, however the achievable neurotoxic possible of these mushrooms should not be dismissed.\nBecause the mind metabolizes lysergic acid solution diethylamide, the person experiences a range of warning signs which include: anxiousness, anxiety and panic attacks, seizures, agitation, uneasiness, euphoria and hyperthermia aesthetic illusions, weakeneddepersonalization and judgment, damaged remembrance, becoming easily irritated, and depersonalization. As the actual system through which lysergic acid solution diethylamide delivers these effects is absolutely not regarded, there may be data that implies that the ingredient can interfere with the ordinary running of unique head cellular varieties, producing strange perform in neurons in the head.\nTherefore Our Home Page , it is important to stay away from ingesting any mushrooms that contains lysergic acid solution diethylamide. People who have encountered adverse reactions to lysergic acidity diethylamide must stay away from ingesting the chemical. or exercise caution when utilizing or taking in fresh mushrooms that contain lysergic acid solution diethylamide, in addition to other fresh mushrooms including lysergic acidity diethylamide.", "domain": "chemistry", "round": 3} +{"url": "https://research.pasteur.fr/en/publication/functional-plasticity-and-allosteric-regulation-of-%CE%B1-ketoglutarate-decarboxylase-in-central-mycobacterial-metabolism/", "date": "2023-10-04T11:07:51Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233511364.23/warc/CC-MAIN-20231004084230-20231004114230-00394.warc.gz", "language_score": 0.9240090250968933, "token_count": 252, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__142261701", "lang": "en", "text": "Link to Pubmed [PMID] – 21867916\nLink to DOI – 10.1016/j.chembiol.2011.06.004\nChem Biol 2011 Aug; 18(8): 1011-20\nThe α-ketoglutarate dehydrogenase (KDH) complex is a major regulatory point of aerobic energy metabolism. Mycobacterium tuberculosis was reported to lack KDH activity, and the putative KDH E1o component, α-ketoglutarate decarboxylase (KGD), was instead assigned as a decarboxylase or carboligase. Here, we show that this protein does in fact sustain KDH activity, as well as the additional two reactions, and these multifunctional properties are shared by the Escherichia coli homolog, SucA. We also show that the mycobacterial enzyme is finely regulated by an additional acyltransferase-like domain and by the action of acetyl-CoA, a powerful allosteric activator able to enhance the concerted protein motions observed during catalysis. Our results uncover the functional plasticity of a crucial node in bacterial metabolism, which may be important for M. tuberculosis during host infection.", "domain": "chemistry", "round": 3} +{"url": "http://ieeexplore.ieee.org/xpl/articleDetails.jsp?reload=true&tp=&arnumber=4420834&contentType=Conference+Publications&sortType%3Dasc_p_Sequence%26filter%3DAND(p_IS_Number%3A4420811)", "date": "2015-04-21T01:28:16Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2015-18/segments/1429246639674.12/warc/CC-MAIN-20150417045719-00053-ip-10-235-10-82.ec2.internal.warc.gz", "language_score": 0.9025540351867676, "token_count": 299, "dump": "CC-MAIN-2015-18", "global_id": "webtext-fineweb__CC-MAIN-2015-18__0__141266364", "lang": "en", "text": "Skip to Main Content\nGiant unilamellar vesicles (GUVs), or giant liposomes (GLs), are biochemical compartments enclosed with phospholipid bilayers. The size of GUVs is comparable to that of real cells (~10-100 mum). Thus, GUVs are employed to construct artificial cell models, which are reconstituted from biochemical materials to mimic real cellular functions in a simpler manner for investigation of fundamental mechanisms of living systems. However, transmembrane proteins are difficult to reconstitute on GUV bilayers. In order to obtain GUVs containing transmembrane proteins, giant proteoliposomes, here, we introduce the novel method using membrane fusion between GUVs and recombinant baculovirus (Autographa californica nucleopolyhedrovirus (AcNPV)). It is known that the AcNPV budded virus (BV) displays recombinant membrane proteins on their own envelopes. BVs have fusogenic envelope glycoproteins (gp64) sensitive to acidic pH. Combination of these two features may produce giant proteoliposomes. The fusion properties were observed using fluorescence microscopy to comprehend conditions suitable for reconstitution of proteoliposomes. The display of a 7-fold transmembrane receptor protein (G protein-coupled receptor) on GUVs was also demonstrated using fluoroimmuno microscopic observation.", "domain": "chemistry", "round": 3} +{"url": "https://pubmed.ncbi.nlm.nih.gov/10642824/?dopt=Abstract", "date": "2021-01-21T03:20:03Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-04/segments/1610703522150.18/warc/CC-MAIN-20210121004224-20210121034224-00407.warc.gz", "language_score": 0.9270045161247253, "token_count": 326, "dump": "CC-MAIN-2021-04", "global_id": "webtext-fineweb__CC-MAIN-2021-04__0__174448461", "lang": "en", "text": "Calcium ions and calcium-dependent systems have been implicated in the pathophysiology of status epilepticus (SE). However, the dynamics of intracellular calcium ([Ca2+]i) levels during SE has not yet been studied. We have employed the hippocampal neuronal culture (HNC) model of in vitro SE that produces continuous epileptiform discharges to study spatial and dynamic changes in [Ca2+]i levels utilizing confocal laser scanning microscopy and the calcium binding dye, indo-1. During SE, the average [Ca2+]i levels increased from control levels of 150-200 nM to levels of 450-600 nM. This increased [Ca2+]i was maintained for the duration of SE. Following SE, [Ca2+]i levels gradually returned to basal values. The duration of SE was shown to affect the ability of the neuron to restore resting [Ca2+]i levels. Both N-methyl-D-aspartate (NMDA) receptor-gated and voltage-gated Ca2+ channels (VGCCs) contributed to the increased calcium entry during SE. Moreover, this elevation in [Ca2+]i occurred in both the nucleus and cytosol. These results provide the first dynamic measurement of [Ca2+]i during prolonged electrographic seizure discharges in an in vitro SE model and suggest that prolonged epileptiform discharges give rise to abnormal sustained increases in [Ca2+]i levels that may play a role in the neuronal cell damage and long-term plasticity changes associated with SE.", "domain": "chemistry", "round": 3} +{"url": "https://www.cephamls.com/histone-h2a-xphospho-thr120-rabbit-polyclonal-antibody/", "date": "2023-03-25T11:30:01Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-14/segments/1679296945323.37/warc/CC-MAIN-20230325095252-20230325125252-00791.warc.gz", "language_score": 0.8189520239830017, "token_count": 341, "dump": "CC-MAIN-2023-14", "global_id": "webtext-fineweb__CC-MAIN-2023-14__0__106648471", "lang": "en", "text": "H2A histone family member X antidoby; H2AFX antibody; H2AX Histoneh antibody; Histone H2AX antibody\nPeptide sequence around phosphorylation site of threonine 120(K-K-T(p)-S-A) derived from Human Histone H2A.X.\nHuman Rat Mouse\nWB Recommended dilution: Western blotting: 1:1000~1:2000,\nBackground / Function\nHistone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.\nRabbit Antiserum, containing 0.02% sodium azide as Preservative and 50% Glycerol.\nShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.\nAntibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.", "domain": "chemistry", "round": 3} +{"url": "https://truedrips.com/product/lg-he2-3-7v-2500mah-high-drain-35a-18650-li-on-battery/", "date": "2019-10-17T04:05:36Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-43/segments/1570986672548.33/warc/CC-MAIN-20191017022259-20191017045759-00463.warc.gz", "language_score": 0.8502075672149658, "token_count": 346, "dump": "CC-MAIN-2019-43", "global_id": "webtext-fineweb__CC-MAIN-2019-43__0__57313030", "lang": "en", "text": "High discharge LG IMR cells offers a massive 35 Amp pulse discharge rate. This high current discharge rate allows the battery to suffer less from voltage sag when powering low resistance setups.\nCapacity is 2500mAh for lengthy vape sessions, while being able to maintain higher voltages over a longer period of time and less voltage drop than other batteries.\nModel: LE DGHR 2185\nMaximum Continuous Charging Current: 4A\nMaximum Continuous Discharging Current: 20A\nMaximum Pulse Discharging Current: 35A\nRated Capacity: 2500mAh\nNominal Voltage: 3.7V\nMaximum Charged Voltage: 4.25V\nMinimum Discharge Voltage: 2.5V\nNOTE: Use special caution when working with Li-ion cells, they are very sensitive to charging characteristics and may explode or burn if mishandled. Make sure the user has enough knowledge of Li-Ion rechargeable batteries in charging, discharging and assembly before use. Always charge in/on a fire-proof surface. Never leave charging batteries unattended. We are not responsible for damage if there is any modification of the batteries/chargers in any form or shape (including pack making). We are not responsible for any damage caused by misuse or mishandling of Li-Ion batteries and chargers. We only recommend using Lithium Ion rechargeable batteries with a control circuit (protection PCB) to assure safe charge, discharge, etc, use of lithium ion batteries without a protection circuit is potentially hazardous.\nOnline Payment Processing is Down, Please call 1(586)-731-0556 at your convenience to place a phone order! (All orders placed before 3:00PM gets shipped SAME DAY) Dismiss", "domain": "chemistry", "round": 3} +{"url": "http://www.lyceum126.ru/user/view/9508", "date": "2018-06-19T03:04:50Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-26/segments/1529267861752.19/warc/CC-MAIN-20180619021643-20180619041643-00590.warc.gz", "language_score": 0.9436314702033997, "token_count": 341, "dump": "CC-MAIN-2018-26", "global_id": "webtext-fineweb__CC-MAIN-2018-26__0__35792417", "lang": "en", "text": "Synonyms for carbon dating Online sex chat on java mobile\nThe regional groups are differentiated by their individual painted wares, but the group of cultures is unified by non-ceramic traits such a miniature polished bone spoons, lip-plugs, rod-head figurines, and stamp seals.The vast majority of early FTN sites are located in the major river valleys of the Balkans, either as tell settlements or as short-lived flat sites.Collins English Dictionary - Complete & Unabridged 2012 Digital Edition © William Collins Sons & Co. 1979, 1986 © Harper Collins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012 Cite This Source radiocarbon dating A technique for measuring the age of organic remains based on the rate of decay of carbon 14.Because the ratio of carbon 12 to carbon 14 present in all living organisms is the same, and because the decay rate of carbon 14 is constant, the length of time that has passed since an organism has died can be calculated by comparing the ratio of carbon 12 to carbon 14 in its remains to the known ratio in living organisms. Our Living Language : In the late 1940s, American chemist Willard Libby developed a method for determining when the death of an organism had occurred.\nThese words appear in red, and are graded with stars. It is a very different form of carbon, no doubt you think, to tinder. You can combine it with other things, but if you have only carbon you can get nothing out of the carbon but carbon. A generator is made of iron, copper, carbon, and insulation. Carbon will combine with hydrogen, but will drop it if it can get oxygen.", "domain": "chemistry", "round": 3} +{"url": "http://www.jurnal.lipi.go.id/publikasi.cgi?tampilpublikasi&1074191983&Inggris&5&SFN19-0502", "date": "2019-01-16T22:11:53Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-04/segments/1547583657907.79/warc/CC-MAIN-20190116215800-20190117001800-00137.warc.gz", "language_score": 0.8732506036758423, "token_count": 277, "dump": "CC-MAIN-2019-04", "global_id": "webtext-fineweb__CC-MAIN-2019-04__0__161679221", "lang": "en", "text": "Physics Journal of the Indonesian Physical Society\nBACK SCATTERING SPECTROMETER FOR THE MEASUREMENT OF WATER POLLUTION LEVEL\nM. Z. Mat Jafri1, K. Abdullah1, M. N. Abu Bakar1 and S. Marshall2\n1School of Physics, Universiti Sains Malaysia, 11800 Penang, Malaysia\nEEE Department, University of Strathclyde, Glasgow G1 1XW, UK2\nThe conventional method used to measure the pollution level of water is by collecting samples and analysing them in the lab. This method is not efficient and cannot provide a real-time result, whereas, digital image processing and remote sensing techniques have been widely used in estimating and mapping water pollution levels in vast areas. Various algorithms have been developed and used for the measurement of the water pollution level. In this work, an algorithm developed for remote sensing techniques is used. The technique employed involves radiating the samples with a laser and then correlating the backscattering with water pollution level. A laser emitting multiple wavelengths are radiated into the water sample and backscattering radiations for every wavelength are analysed and corelated with the polutant concentration. The backscattering radiation is then analysed and the proposed water quality algoritm is calibrated for measuring the pollution level of the samples.", "domain": "chemistry", "round": 3} +{"url": "http://onlinelibrary.wiley.com/doi/10.1111/j.1945-5100.2012.01346.x/references", "date": "2016-09-29T05:51:22Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2016-40/segments/1474738661778.39/warc/CC-MAIN-20160924173741-00156-ip-10-143-35-109.ec2.internal.warc.gz", "language_score": 0.6759063005447388, "token_count": 873, "dump": "CC-MAIN-2016-40", "global_id": "webtext-fineweb__CC-MAIN-2016-40__0__110182548", "lang": "en", "text": "Sources of insoluble inclusions in stratospheric sulfate particles\nVersion of Record online: 10 MAY 2012\n© The Meteoritical Society, 2012\nMeteoritics & Planetary Science\nVolume 47, Issue 5, pages 799–805, May 2012\nHow to Cite\nBIGG, E. K. (2012), Sources of insoluble inclusions in stratospheric sulfate particles. Meteoritics & Planetary Science, 47: 799–805. doi: 10.1111/j.1945-5100.2012.01346.x\n- Issue online: 22 MAY 2012\n- Version of Record online: 10 MAY 2012\n- (Received 14 June 2011; revision accepted 20 February 2012)\n- 2009. Infrared spectroscopy of Wild 2 particle hypervelocity tracks in Stardust aerogel: Evidence for the presence of volatile organics in cometary dust. Meteoritics & Planetary Science 44:471–484. , , , , and\n- 1975. Stratospheric particles. Journal of Atmospheric Science 32:910–917.\n- 1976. Size distribution of stratospheric aerosols and their variations with altitude and time. Journal of Atmospheric Science 33:1080–1086.\n- 2003. Brochosomes–A tracer for near-surface air. Atmospheric Research 66:141–143.\n- 1968. Gemini-12 meteoritic dust experiment results. In Space Research VIII, edited by A. P. , , and Amsterdam: North-Holland Publishing. pp. 536–542. , , and .,\n- 2010. Complex aromatic hydrocarbons in Stardust samples collected from comet 81P/Wild 2. Meteoritics & Planetary Science 45:701–722. , , , , and\n- 2001. Ablation, flux, and atmospheric implications of meteors inferred from stratospheric aerosol. Science 291:1772–1775. , , and\n- 2009. Cometary glycine detected in samples returned by Stardust. Meteoritics & Planetary Science 44:1323–1330. , , and\n- 1970. Examination of surfaces exposed to a noctilucent cloud, August 1, 1968. Journal of Geophysical Research 75:6736–6750. , , and\n- 2009. Mesospheric dust and its secondary effects as observed by the ESPRIT payload. Annales Geophysicae 27:1119–1128. , , and\n- 1964. Investigations of noctilucent cloud particles. Tellus 16: 96–102. , , and .\n- 1980. Smoke and dust particles of meteoric origin in the mesosphere and stratosphere. Journal of Atmospheric Science 37:1342–1357. , , and\n- 1969. Micrometeoroid interaction with the atmosphere. Journal of Geophysical Research 74:1908–1919.\n- 2005. Biogenic particles in the surface microlayer and overlaying atmosphere in the central Arctic Ocean during summer. Tellus 57B:305–316. and\n- 1965. Stratospheric particles at 20 km altitude. Geochimica et Cosmochimica Acta 29:201–207.\n- 1998. In situ measurements of organics, meteoritic material, mercury and other elements in aerosols at 5 to 19 kilometers. Science 282:1664–1669. , , and\n- 2007. Carbonaceous material in aerosol particles in the lower stratosphere and tropopause region. Journal of Geophysical Research 112:D04203, doi:10.1029/2006JD007297 , , and .,\n- 2010. Comet 81P/Wild 2: The size distribution of finer (sub-10 μm) dust collected by the Stardust spacecraft. Meteoritics & Planetary Science 45:1409–1428. , , , , , , , , , , , , , , , , , and\n- 1961. Secondary particulate matter from meteor vapors. Journal of Meteorology 18:736–745. and\n- 1964. Composition analysis of particles from noctilucent clouds. Tellus 16:103–109. , , , , and", "domain": "chemistry", "round": 3} +{"url": "http://iuhookuponlinershp.thebreakroom.us/3-assumptions-of-radiometric-dating.html", "date": "2018-12-18T21:04:21Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-51/segments/1544376829812.88/warc/CC-MAIN-20181218204638-20181218230638-00376.warc.gz", "language_score": 0.9433656334877014, "token_count": 1081, "dump": "CC-MAIN-2018-51", "global_id": "webtext-fineweb__CC-MAIN-2018-51__0__13048066", "lang": "en", "text": "These dating methods rely on a series of assumptions about the amounts of the rate found 3 indicators that strongly indicate decay rates changed in the past . In this paper we'll see that radiometric dating is not an accurate way to how old fossils are, because it is based on non-provable assumptions page 3. 3) there has been no contamination of the elements none of the atoms to help you better understand the three assumptions of radiometric. Radiometric dating - a questionable method for establishing the old age of rocks here are the three major assumptions for your consideration: the data has since been refined and updated to give a date of 5680 (+/- 2000) years [3. 321 commentary 322 calibration curves 323 carbon-14 in deeply the researchers started from the assumption that the older radiometric date was.\nDating methods “makes assumptions” and that these “assumptions” while doing so, we will have to learn about how radiometric dating actually works 3 radiometric dating and initial conditions a second property of. Part 3: making sense of the patterns this three-part series will help you properly understand radiometric dating, the assumptions that lead to. Radiometric dating is a method of determining the age of an artifact by there are a number of implausible assumptions involved in radiometric dating rate of decay of a radioactive material is largely constant, and it was. Radiocarbon dating, also known as carbon-14 dating, is one of the most significant libby's first two assumptions were correct, however, the latter assumption a piece of timber from the egyptian pharaoh senusret iii's funerary boat, and is reached and other radiometric dating techniques must be used.\nNow that you know the theory, we can highlight the assumptions old or diamonds which are believed to be 1 to 3 billion years old my next blog will discuss another radiometric dating method that is even more interesting. Radiometric dating and applications to sediment transport the isotope 40k is one of 3 isotopes of potassium (39k, 40k and 41k) and is about 001% of no ar is lost from the lava after formation (this assumption can be violated if the rock . This is a significant assumption made in the carbon dating process which is known obtained using radiometric methods for τd 3 cal kbp.\nList at least 9 of the false assumptions made with radioactive dating methods all radiometric dating systems are range there are 3 faulty assumptions with radiometric dating all 3 have been proven to factor into dating. Radiometric dating techniques relies upon assumptions to help you understand the reality of radiometric dating, think of it like this: if you were. Assumption one: the radioisotope decay rates have been constant throughout the past we know that some elements decay over time into another element, ie, .\nPotassium–argon dating, abbreviated k–ar dating, is a radiometric dating method used in potassium naturally occurs in 3 isotopes: 39 this is a well founded major assumption, common to all dating methods based on radioactive decay. Comments on the radiometric dating game - part 3 in response to hovind's several faulty assumptions are used in radiometric dating. One of the assumptions of the radiocarbon dating method is that the global concentration of carbon-14 has not changed over time nuclear weapons testing has. Data and what you have read about the assumptions of radiometric dating answer the following questions you encounter a site that has 3% carbon 14 ( . Read the pros and cons of the debate radiometric dating is accurate 3 the dates obtained by different radiometric isotope pairs cross-check each other so the major assumptions in the method would, therefore, appear to be valid for.\nRadiometric dating involves dating rocks or other objects by measuring the extent to 3 types of dating this is consistent with the assumption that each decay event is independent and its chance does not vary over time. Principles of the major radiometric dating methods, to illustrate how they are used time (3) the assumption that the process rate was (cad. However, this method makes 3 big assumptions in order to work: the amount does radiometric dating prove the earth is old icr: doesn't. The problem with radiometric dating is, if the assumptions which must be used to proverbs 3:5-6 is a great reminder concerning how to handle the question.\nIn addition the assumptions needed to help understand the results in a creation paradigm introduction to radiometric dating techniques introduces you to. Assumptions about radiometric dating interweaving the relative time scale with the atomic time scale poses certain problems because only certain types of rocks . Radiometric dating is a much misunderstood phenomenon although assumptions 2 and 3 are not provable, they actually seem very likely in. Contents ▫ principles of conventional k/ar dating and basis of 40ar/39ar the 40ar/36ar ratio was atmospheric 3 the rock became a closed system in a short time fundamental assumptions.\n(3) potassium-argon dating, based on potassium into argon and calcium (7) a basic assumption of all radioactive dating methods is that the clock had to start. Using melting ice to teach radiometric dating donald underkofler wise time of zero progeny b) what assumptions are involved in mination page 3.", "domain": "chemistry", "round": 3} +{"url": "https://dr.ntu.edu.sg/handle/10356/18852", "date": "2021-02-27T17:02:52Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-10/segments/1614178358976.37/warc/CC-MAIN-20210227144626-20210227174626-00385.warc.gz", "language_score": 0.8719055652618408, "token_count": 578, "dump": "CC-MAIN-2021-10", "global_id": "webtext-fineweb__CC-MAIN-2021-10__0__186656478", "lang": "en", "text": "Please use this identifier to cite or link to this item:\n|Title:||Biochemical and structural studies on the molecular interaction between P53 transcriptional activation domain and anti-apoptotic protein BCL-XL||Authors:||Xu, Huibin||Keywords:||DRNTU::Science::Biological sciences::Biochemistry||Issue Date:||2008||Source:||Xu, H. B. (2008). Biochemical and structural studies on the molecular interaction between P53 transcriptional activation domain and anti-apoptotic protein BCL-XL. Doctoral thesis, Nanyang Technological University, Singapore.||Abstract:||This is due to its critical role in the regulation of apoptosis and control of cancer formation. p53 is believed to be the most important tumor suppressor protein and abnormality of p53 causes cancers and many other diseases. Functional studies revealed that p53 is an important transcriptional activator. It initiates transcription of many pro-apoptosis genes, which activate multiple apoptotic pathways and finally induce cell death. Besides its transcription-dependent apoptosis activity, the apoptotic activity of p53 out of the nuclei was also observed and draws attention. p53 interacts with the anti-apoptotic proteins, Bcl-2/XL, and induces mitochondria-mediated apoptosis. The transcription activity of p53 is not involved in this pathway, suggesting transcription-independent mechanism of p53. The p53/Bcl-2 and p53/Bcl-XL interaction were then investigated by different groups. The DNS binding domain of p53 was believed to be the binding site in the p53/Bcl-XL interaction. However, there is no detail structure information of the complex so far. In this study, we identified a novel binding site on p53 N-terminal domain (NTD) for Bcl-XL. The p53 NTD/ Bcl-XL complex was observed and obtained in a co-expression system in E.coli. NMR study also confirmed this physical interaction in vitro. We also showed their interaction in mammalian cells using FRET assay. A preliminary binding interface on Bcl-XL was suggested according to the 1H-15N 2D HSQC NMR titration experiments.||URI:||https://hdl.handle.net/10356/18852||DOI:||10.32657/10356/18852||Fulltext Permission:||open||Fulltext Availability:||With Fulltext|\n|Appears in Collections:||SBS Theses|\nPage view(s) 50411\nUpdated on Feb 27, 2021\nUpdated on Feb 27, 2021\nItems in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.", "domain": "chemistry", "round": 3} +{"url": "https://www.medecinesciences.org/en/articles/medsci/ref/2009/08/medsci2009256-7p562/medsci2009256-7p562.html", "date": "2023-06-02T12:25:16Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-23/segments/1685224648635.78/warc/CC-MAIN-20230602104352-20230602134352-00216.warc.gz", "language_score": 0.7236438393592834, "token_count": 888, "dump": "CC-MAIN-2023-23", "global_id": "webtext-fineweb__CC-MAIN-2023-23__0__22123567", "lang": "en", "text": "Med Sci (Paris)\nVolume 25, Number 6-7, Juin-Juillet 2009\n|Page(s)||562 - 564|\n|Published online||15 June 2009|\n- Farooq M, Haq I, Qureshi AS. Cardiovascular risks of COX inhibition: current perspectives. Exp Opin Pharmacother 2008; 9 : 1311–9. [Google Scholar]\n- Garcin ED, Arvai AS, Rosenfeld RJ, et al. Anchored plasticity opens doors for selective inhibitor design in NOS. Nat Chem Biol 2008; 4 : 700–7. [Google Scholar]\n- Palmer RMJ, Ferrige AG, Moncada S. Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature 1987; 327 : 524–6. [Google Scholar]\n- Ignarro LJ, Buga GM, Wood KS, et al. Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide. Proc Natl Acad Sci USA 1987; 84 : 9265–9. [Google Scholar]\n- Khan MT, Furchgott R. Additional evidence that endothelium-derived relaxing factor is nitric oxide. Amsterdam : Elsevier, 1987. [Google Scholar]\n- Katsuki S, Arnold W, Mittal C, et al. Stimulation of guanylate cyclase by sodium nitroprusside, nitroglycerin and nitric oxide in various tissue preparations and comparison to the effects of sodium azide and hydroxylamine. J Cyclic Nucleotide Res 1977; 3 : 23–35. [Google Scholar]\n- Bian K, Murad F. Nitric oxide (NO): biogeneration, regulation, and relevance to human diseases. Front Biosci 2003; 8 : d264–78. [Google Scholar]\n- Tafi A, Angeli L, Venturini G, et al. Computational studies of competitive inhibitors of nitric oxide synthase (NOS) enzymes: towards the development of powerful and isoform-selective inhibitors. Curr Med Chem 2006; 13 : 1929–46. [Google Scholar]\n- Crane BR, Arvai AS, Ghosh DK, et al. Structure of nitric oxide synthase oxygenase dimer with pterin and substrate. Science 1998; 279 : 2121–6. [Google Scholar]\n- Fischmann TO, Hruza A, Niu XD, et al. Structural characterization of nitric oxide synthase isoforms reveals striking active-site conservation. Nat Struct Biol 1999; 6 : 233–42. [Google Scholar]\n- Raman CS, Li H, Martasek P, et al. Crystal structure of constitutive endothelial nitric oxide synthase: a paradigm for pterin function involving a novel metal center. Cell 1998; 95 : 939–50. [Google Scholar]\n- Flinspach M, Li H, Jamal J, et al. Structures of the neuronal and endothelial nitric oxide synthase heme domain with D-nitroarginine-containing dipeptide inhibitors bound. Biochemistry 2004; 43 : 5181–7. [Google Scholar]\n- Fedorov R, Hartmann E, Ghosh DK, et al. Structural basis for the specificity of the nitric-oxide synthase inhibitors W1400 and N(omega)-propyl-L-arg for the inducible and neuronal isoforms. J Biol Chem 2003; 278 : 45818–25. [Google Scholar]\nCurrent usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.\nData correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.\nInitial download of the metrics may take a while.", "domain": "chemistry", "round": 3} +{"url": "https://www.antibodies-online.com/abstract/Myoferlin+(MYOF)+ELISA+Kit/", "date": "2018-04-21T23:20:11Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-17/segments/1524125945459.17/warc/CC-MAIN-20180421223015-20180422003015-00207.warc.gz", "language_score": 0.8808748126029968, "token_count": 949, "dump": "CC-MAIN-2018-17", "global_id": "webtext-fineweb__CC-MAIN-2018-17__0__64232867", "lang": "en", "text": "Use your antibodies-online credentials, if available.\nNo Products on your Comparison List.\nYour basket is empty.\nFind out more\nMutations in dysferlin, a protein associated with the plasma membrane, can cause muscle weakness that affects both proximal and distal muscles. Additionally we are shipping Myoferlin Antibodies (21) and and many more products for this protein.\nShowing 2 out of 7 products:\nMyoferlin is a general component of cancer cell derived exosomes from different breast and pancreatic cancer cell lines.\nthe cleavage of myoferlin, yielding a membrane-associated dual C2 domain 'mini-myoferlin', is reported.\nA novel regulator, myoferlin, of ADAM12 (show ADAM12 ELISA Kits) is discovered in HeLa cells and this protein increases ADAM12 (show ADAM12 ELISA Kits) expression level, stability, and its enzymatic activity, leading to the reduction of its substrate, E-cadherin (show CDH1 ELISA Kits), which plays important roles in the regulation of cell adhesion and tumor metastasis.\nData show myoferlin depletion did not affect STAT3 (show STAT3 ELISA Kits) transcription factor (STAT3 (show STAT3 ELISA Kits)) phosphorylation, but completely blocked STAT3 (show STAT3 ELISA Kits) translocation to nucleus.\nThis study is the first to report robust age associations for DNA methylation in MYOF and DDO (show DDO ELISA Kits), both of which have plausible functional roles in aging\nResults demonstrate for the first time that nuclear myoferlin expression independently predicts poor clinical outcome in OPSCC patients.\nMyoferlin plays a key role in VEGFA (show VEGFA ELISA Kits) secretion and impacts tumor-associated angiogenesis in human pancreas cancer.\nMYOF regulates cell adhesions and cell-substrate adhesion strength and may account for the high degree of motility in invasive breast cancer cells.\nThese data provide the first evidence of myoferlin expression in solid human and mouse tumors.\nData indicate that dysferlin (show DYSF ELISA Kits), otoferlin, and myoferlin do not merely passively adsorb to membranes but actively sculpt lipid bilayers.\nthese findings demonstrate the importance of dysferlin (show DYSF ELISA Kits) and myoferlin for transverse tubule function and in the genesis of muscular dystrophy.\nMyoferlin gene knockdown not only decreases lipid vesicle fusion in EC but also attenuates Vascular Endothelial Growth Factor (VEGF (show VEGF ELISA Kits)) Receptor-2 (VEGFR-2) expression.\nIGF1 (show IGF1 ELISA Kits) receptor recycling is required for normal myogenesis and myoferlin is a critical mediator of postnatal muscle growth mediated by IGF1 (show IGF1 ELISA Kits)\nCalcium-sensitive phospholipid binding properties of normal and mutant ferlin C2 domains. (myoferlin)\nmyoferlin plays role in the maturation of myotubes and the formation of large myotubes that arise from the fusion of myoblasts to multinucleate myotubes.\nmyoferlin forms a complex with dynamin-2 (show DNM2 ELISA Kits) and VEGFR-2 (show KDR ELISA Kits), which prevents CBL (show CBL ELISA Kits)-dependent VEGFR-2 (show KDR ELISA Kits) polyubiquitination and proteasomal degradation.\ninteraction of myoferlin with EHD2 identifies molecular overlap between the endocytic recycling pathway and the machinery that regulates myoblast membrane fusion\nMutations in dysferlin, a protein associated with the plasma membrane, can cause muscle weakness that affects both proximal and distal muscles. The protein encoded by this gene is a type II membrane protein that is structurally similar to dysferlin. It is a member of the ferlin family and associates with both plasma and nuclear membranes. The protein contains C2 domains that play a role in calcium-mediated membrane fusion events, suggesting that it may be involved in membrane regeneration and repair. Two transcript variants encoding different isoforms have been found for this gene. Other possible variants have been detected, but their full-length nature has not been determined.\nfer-1-like 3, myoferlin\n, fer-1-like protein 3\n, Fer-1-like protein 3", "domain": "chemistry", "round": 3} +{"url": "https://www.globalspec.com/learnmore/manufacturing_process_equipment/fluid_processing_equipment/tanks_vessels/storage_tanks_process_tanks", "date": "2024-02-27T04:53:45Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707947474670.19/warc/CC-MAIN-20240227021813-20240227051813-00034.warc.gz", "language_score": 0.9147487878799438, "token_count": 575, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__26875981", "lang": "en", "text": "Storage Tanks and Process Tanks Information\nStorage tanks and process tanks are general purpose industrial containers that can have many configurations depending upon dimensions, orientation, placement, and wall configuration.\nStorage tanks and process tanks are used in a number of applications including short term storage, long term storage, mixing, blending, metering and dispensing. Materials of construction will dictate the application that is suitable for the tank.\nCommon industries and applications that use storage tanks and process tanks include:\n- Chemical processing\n- Cosmetics processing\n- Food and beverage processing\n- Oil and fuel processing\n- Paper and pulp processing\n- Pharmaceutical processing\n- Plastic processing\n- Power generation\n- Energy processing\n- Water applications\nVideo Credit: Xerxes Corporation\nThe most important parameters to consider when specifying storage tanks and process tanks are their capacity and dimensions. The capacity of the storage tank or process tank is the internal volume available for the storage of materials. The diameter of the tank is typically expressed in feet units. The length of the tank is measured in feet.\nThe orientation of the tank can be vertical or horizontal. Vertical tanks stand vertically and typically have access ports on the bottom. Horizontal tanks are often mounted on stands or saddles and can have access ports on the bottom or top. The placement of tanks is typically either above ground or underground, depending on the construction. Portable tanks can be moved from one place to another, via wheels or other moving device.\nThe wall construction of the tank may dictate the application that the tank is suitable for. Single wall tanks are common for various applications. Double wall tanks are used in applications where higher-pressure considerations are necessary.\nMaterials of Construction\nStorage tanks and process tanks can be constructed from a variety of materials.\nFiberglass reinforced polyester (FRP) is made of a series of long glass fibers embedded in a resin. It can be formed into almost any shape before curing. Once cured it is light in weight, very strong material that has excellent corrosion resistant properties. In some cases, fiberglass is used along with the plastic in the body material of the tank.\nGalvanized steel is cold rolled steel that has been surface treated with a layer of zinc.\nStainless steel is a type of metal that resists corrosion.\nSteel is a ferrous-based metal having a variety of physical properties depending on composition. Steel used in tank applications is typically rolled sheet steel.\nTitanium is a lightweight, very strong metal used in applications where there are temperature extremes or extraordinary stresses.\nStorage tanks and process tanks with special linings are constructed of special materials for corrosive or other special processes. Considerations might also include glass lined or special coatings.\nAFI 32-7044 - Storage tank environmental compliance\nAPI PUBL 327 - Aboveground storage tank standards: a tutorial", "domain": "chemistry", "round": 3} +{"url": "https://ebeamservices.com/blog/electron-beam-rheology-control/", "date": "2024-04-24T11:41:45Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712296819273.90/warc/CC-MAIN-20240424112049-20240424142049-00092.warc.gz", "language_score": 0.9145482778549194, "token_count": 803, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__159730759", "lang": "en", "text": "Does your PE or PP resin have the exact material properties you want?\nIf you’re manufacturing a specialty film, bottle, foam, or other plastic product, the standard off-the-shelf grades offered by the big resin manufacturers don’t always meet your needs.\nIt’s like when you go to buy a new suit. Often, something off the rack fits you just fine. But, sometimes, they don’t have your size or it doesn’t fit right.\nWhat if you could get a tailored solution?\nFor example, you might need a certain melt index for your product or maybe you need a resin with better properties than the standard grade. In many cases, there is a way you can tailor a standard resin to give you the properties you want and have it work well in your equipment.\nHow’s that possible? By using electron beam processing.\nLet’s look at how one company is using electron beam processing to solve a problem. They have an application that requires a low melt flow but the specialty resin is expensive, and its availability is limited. They found that they can start with a low-cost grade of polyethylene then reduce the melt index by using an electron beam to achieve the exact melt flow they want for their application and for their equipment.\nIn some cases, a new material can be created that’s unattainable from the resin manufacturers.\nHere’s another example using polypropylene. A company needs a higher melt index than what they can get from a standard grade. They can start with a standard grade and then have it electron beamed to get the high melt flow they need.\nMillions of pounds of bulk resins are regularly processed using e-beam for just such applications. The combined cost of the starting material and the e-beam step can be below the cost of the expensive specialty resins.\nYou may not have heard of the electron beam process because manufacturers often consider this step as their trade secret.\nHere’s how it works.\nA shower of fast electrons strikes the product as it’s conveyed through the beam. The long-chain molecules of the polymer are ionized by the fast electrons. This creates an improved branched polymer.\nInstead of a high-cost, hard-to-get low density polyethylene, what if you start with a low-cost linear low density polyethylene? When the linear low is electron beamed, you get the melt strength you need for foaming or thermoforming. And you get the higher temperature rating inherent in linear low.\nE-BEAM Services makes it simple and straightforward for you to use this tool. E-BEAM helps you do the experimental work to determine what works best in your process. Once you demonstrate success in your plant, E-BEAM can produce your specialty resin in any quantity you require, from gaylords to multiple bulk hopper trucks or even railcar quantities.\nE-BEAM will work with you to get the best logistics. E-BEAM operates a network of powerful electron beam accelerators, with cost-effective plant utilization and a high level of processing efficiency.\nWhichever manufacturing process you’re using, you can get a competitive advantage with electron beam.\nSo, how do you get started?\nYou can contact one of E-BEAM’s friendly tech services representatives to explore your problem or opportunity.\nFor more than 20 years, E-BEAM has been processing millions of pounds per year of bulk resins. E-BEAM makes it simple and straightforward for you to create a tailored specialty resin, and it becomes your trade secret. Our motto is: “Our customers make great products.”", "domain": "chemistry", "round": 3} +{"url": "https://cris.huji.ac.il/en/publications/c-cbl-mediated-ubiquitinylation-is-required-for-epidermal-growth", "date": "2023-09-24T22:58:07Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233506669.96/warc/CC-MAIN-20230924223409-20230925013409-00404.warc.gz", "language_score": 0.9102841019630432, "token_count": 359, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__78880729", "lang": "en", "text": "Epidermal growth factor receptor (EGFR) controls cell growth and has a key role in tumorigenic processes. The extent of EGFR signaling is tightly regulated by post-transcriptional modifications leading to down-regulation of the levels of the receptor. Previous studies from our laboratory demonstrated that the reactive oxidant hydrogen peroxide activates the EGFR, yet, without down-regulation of the receptor levels, which results in prolonged receptor signaling. In the present study we examined the role of the E3 ligase c-Cbl, as a possible link between oxidative stress, EGFR signaling, and tumorigenic responses. First, we ectopically expressed a mutant EGFR (Tyr-1045 → Phe) in cells lacking endogenous receptor, to determine whether the lack of phosphorylation at this site is the cause for EGFR retention at the membrane under oxidative stress, as we have previously suggested. Our findings suggest that abrogation of tyrosine 1045 phosphorylation alone is not enough to retain the EGFR at the plasma membrane under oxidative stress. Second, through the use of the Src inhibitor PP1, our findings establish EGFR movement out of the early endosomes as the exact location where c-Cbl-mediated ubiquitinylation is essential for EGFR trafficking. Finally, our studies substantiate the findings that c-Cbl-mediated ubiquitinylation is needed for degradation, but not for internalization of the EGFR in both transfection-dependent Chinese hamster ovary cells and transfection-independent A549 lung epithelial cells. These findings only begin to explain the features seen under oxidative stress, but they yield a greater understanding of the role of c-Cbl in EGFR trafficking.", "domain": "chemistry", "round": 3} +{"url": "http://www.koreascience.or.kr/article/JAKO201607433788615.page", "date": "2019-04-20T03:05:36Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-18/segments/1555578528481.47/warc/CC-MAIN-20190420020937-20190420042937-00557.warc.gz", "language_score": 0.667503833770752, "token_count": 1258, "dump": "CC-MAIN-2019-18", "global_id": "webtext-fineweb__CC-MAIN-2019-18__0__83675610", "lang": "en", "text": "- Volume 53 Issue 1\nTin oxide (\nY. Liu, Y. Jiao, Z. Zhang, F. Qu, A. Umar, and X. Wu, \"Hierarchical\n$SnO_2$Nanostructures Made of Intermingled Ultrathin Nanosheets for Environmental Remediation, Smart Gas Sensor, and Supercapacitor Applications,\" ACS Appl. Mater. Interface, 6 2174-84 (2014). https://doi.org/10.1021/am405301v\nQ. Zhao, D. Ju, X. Deng, J. Huang, B. Cao, and X. Xu, \"Morphology-Modulation of\n$SnO_2$Hierarchical Architectures by Zn Doping for Glycol Gas Sensing and Photocatalytic Applications,\" Sci. Rep., 7874 1-5 (2015).\nL. C. Nehru and C. Sanjeeviraja, \"Rapid Synthesis of Nanocrystalline\n$SnO_2$by a Microwave-Assisted Combustion Method,\" J. Adv. Ceram., 3 171-76 (2014). https://doi.org/10.1007/s40145-014-0101-5\nY. Han, X. Wu, G. Shen, B. Dierre, L. Gong, F. Qu, Y. Bando, T. Sekiguchi, F. Filippo, and D. Golberg, \"Solution Growth and Cathodoluminescence of Novel\n$SnO_2$Core-Shell Homogeneous Microspheres,\" J. Phys. Chem. C., 114 8235-40 (2010).\n- H. Taib and C. C. Sorrell, \"Preparation of Tin Oxide,\" J. Aust. Ceram. Soc., 43 56-61 (2007).\nL. M. Sikhwivhilu, S. K. Pillai, and T. K. Hillie, \"Influence of Citric Acid on\n$SnO_2$Nanoparticles Sythesized by Wet Chemical Processes,\" J. Nanosci. Nanotech., 11 4988-94 (2011). https://doi.org/10.1166/jnn.2011.3930\nY. Cui, A. Yu, H. Pan, X. Zhou, and X. Ding \"Catalytic Outgrowth of\n$SnO_2$Nanorods from ZnO- $SnO_2$Nanoparticles Microsphere Core: Combustion Synthesis and Gas-Sensing Properties,\" Cryst. Eng. Comm., 14 7355-59 (2012). https://doi.org/10.1039/c2ce25810b\nA. Ayeshamariam, V. S. Vidhya, T. Sivakumar, R. Mahendran, R. Perumalsamy, N. Sethupathy, and M. Jayachandran \"Nanoparticles of\n$In_2O_3$/ $SnO_2$(90/10) and (80/20) at Two Different Proportions and Its Properties,\" Open J. Met., 3 1-7 (2013).\nM. Bhagwat, P. Shah, and V. Ramaswamy, \"Synthesis of Nanocrystalline\n$SnO_2$Powder by Amorphous Citrate Route,\" Mater. Lett., 57 1604-11 (2003). https://doi.org/10.1016/S0167-577X(02)01040-6\n- S. Banerjee, A. Bumajdad, and P. S. Devi \"Nanoparticles of Antimony Doped Tin Dioxide as a Liquid Petroleum Gas Sensor: Effect of Size on Sensitivity,\" Nanotechnol., 22 1-8 (2011).\nL. B. Fraigi, D. G. Lamas, and N. E. Wals e de Reca, \"Comparison between Two Combustion Routes for the Synthesis of Nanocrystalline\n$SnO_2$Powders,\" Mater. Lett., 47 262-66 (2001). https://doi.org/10.1016/S0167-577X(00)00246-9\nA. Bhattacharjee and M. Ahmaruzzaman, \"A Green Approach for the Synthesis of\n$SnO_2$Nanoparticles and its Application in the Reduction of p-nitrophenol,\" Mater. Lett., 157 260-64 (2015). https://doi.org/10.1016/j.matlet.2015.05.053\n- K. S. W. Sing, D. H. Everett, R. A. W. Haul, L. Moscou, R. A. Pierotti, J. Rouquerol, and T. Siemieniewska, \"REPORTING PHYSISORPTION DATA FOR GAS/SOLID SYSTEMS with Special Reference to the Determination of Surface Area and Porosity,\" Pure Appl. Chem., 57 603-19 (1985). https://doi.org/10.1351/pac198557040603\nS. A. Feyzabad, Y. Mortazavi, A. A. Khodadadi, and S. Hemmati, \"\n$Sm_2O_3$Doped- $SnO_2$Nanoparticles, Very Selective and Sensitive to Volatile Organic Compounds,\" Sens. Actuators, B, 181 910-18 (2013). https://doi.org/10.1016/j.snb.2013.02.101\nSupported by : Chonnam National University", "domain": "chemistry", "round": 3} +{"url": "https://paramountperformance.com/carbon-clean-service/", "date": "2023-09-27T02:27:06Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233510238.65/warc/CC-MAIN-20230927003313-20230927033313-00201.warc.gz", "language_score": 0.9291755557060242, "token_count": 716, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__254820041", "lang": "en", "text": "Does your car have: poor fuel economy? Lack power? Idle rough? Make a pinging sound?\nA logbook service is not the only service you should be booking your car in for.\nWhile ensuring your vehicle is kept up to date with its service schedule is important there is another service that is often overlooked for your petrol-powered vehicle- A Carbon Clean Service!\nThe carbon clean system offered at our workshop is the petrol fuel system service of the new Millennium!\nCarbon Build up is your vehicle’s unseen enemy! Due to the poor fuel quality in Australia our cars engines with everyday driving gum up with carbon. These carbon deposits can cause Poor fuel economy, a lack in power, rough idle and pinging (detonation). Independent tests prove the carbon clean service improves fuel economy, Increases Horsepower and reduces exhaust emissions by increasing the operating efficiency of the engine. Most important is the feeling you will get when you feel the performance restored in your car.\nHow it works…\nThe cleaning system connects to the engine via specifically designed adapters, temporarily taking place of the vehicles fuel supply system. The system circulates a potent mixture of carbon clean chemical and fuel throughout the fuel system. The carbon clean chemical is the safest and most effective cleaner on the market. This chemical is safe for all engine and fuel system components.\nDuring the first phase of cleaning, with the engine off, the system removes gum and varnish from the fuel rail, pressure regulator and injector filters, filtering out any impurities via an on-board filter that is part on the carbon clean machine.\nThe second stage of cleaning is carried out with the engine running (under load) with your car on our Dyno Dynamics Dynamometer, the chemical is passed through the injectors and into the combustion chamber. The chemical desiccates the soft carbon deposits lodged on the back of the inlet valves and ports as well as in the combustions chamber. These deposits are then passed through the engine and out of the exhaust.\nHow is a carbon tune different from the do-it-yourself injector cleaners you can buy at the shops?\nMost of the injector cleaners currently on the market are too diluted already in the bottle only to be diluted even further when added to the fuel tank to actually be of benefit. To effectively remove carbon deposits from the engine it must be done with the engine under varying load & speeds, in-tank injector cleaner does not offer this either.\nDoes a Carbon Tune improve engine life? Yes!\nHow? Because our Dyno Dynamics dynamometer enables us to simulate conditions that allow oil temperature to rise above normal road going temperature, unburnt fuel and water, contaminating the engine oil, simply boils off. In addition, under these conditions, detergent action in engine oil really gets going and eats up varnish and carbon deposits in the engine.\nThe benefits of a carbon Tune (dyno de-coke) are:\n• Performance and economy are usually improved by up to 10-15 percent\n• Part throttle response is improved\n• “Pinging” is generally totally cured\n• The Engine runs and idles smoother.\nThe Motorvac Carbon Clean service will immediately help your engine function more efficiently and will improve your vehicle’s performance in a matter of minutes! We recommend a Carbon Clean service every 12-18 months- Do your car a favour and restore your cars performance & book your Carbon Clean Service today!", "domain": "chemistry", "round": 3} +{"url": "http://www.antikoerper-online.de/abstract/Solute+Carrier+Family+16%2C+Member+1+(Monocarboxylic+Acid+Transporter+1)+(SLC16A1)+ELISA+Kit/", "date": "2017-11-23T18:47:48Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-47/segments/1510934806856.86/warc/CC-MAIN-20171123180631-20171123200631-00444.warc.gz", "language_score": 0.813714325428009, "token_count": 2257, "dump": "CC-MAIN-2017-47", "global_id": "webtext-fineweb__CC-MAIN-2017-47__0__184726820", "lang": "en", "text": "Use your antibodies-online credentials, if available.\nKeine Produkte auf Ihrer Vergleichsliste.\nIhr Warenkorb ist leer.\nThe protein encoded by SLC16A1 is a proton-linked monocarboxylate transporter that catalyzes the movement of many monocarboxylates, such as lactate and pyruvate, across the plasma membrane. Zusätzlich bieten wir Ihnen SLC16A1 Antikörper (77) und SLC16A1 Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.\nShowing 8 out of 21 products:\nData indicate that monocarboxylate transporters (MCTs1 (zeige MCTS1 ELISA Kits)-4) were all found to be expressed in brains of embryos, and were localized in both neurons and astrocyte.\nThe expression of monocarboxylic acid transporter 1 (MCT1 (zeige MCTS1 ELISA Kits)), MCT2 (zeige SLC16A7 ELISA Kits), and CD147 in 3 horse breeds with different atheletic demands is reported.[MCT1 (zeige MCTS1 ELISA Kits); MCT2 (zeige SLC16A7 ELISA Kits)]\nResults indicated that a single IET resulted in transient increases in MCT1 (zeige MCTS1 ELISA Kits) and MCT4 (zeige SLC16A3 ELISA Kits) mRNA expression and protein content in untrained and trained horses.\nThe coding sequence of MCT1 (zeige MCTS1 ELISA Kits), MCT4 (zeige SLC16A3 ELISA Kits), and CD147 in healthy horses, and the incidence of polymorphisms of these proteins in horses with excercise-induced myopathy are reported.\nMCT1 (zeige MCTS1 ELISA Kits) protein content in GMM samples obtained when the horses were 24 months old was significantly higher than at 2 months of age. However, MCT4 (zeige SLC16A3 ELISA Kits) protein content remained unchanged throughout the study period.\nThe reversible H(+)/lactate(-) symporter MCT1 (zeige CMA1 ELISA Kits) cotransports lactate and proton, leading to the net extrusion of lactic acid in glycolytic tumors. A model of its role in pH control in tumor cells is described. Review.\nIncreased miR (zeige MLXIP ELISA Kits)-210 and concomitant decreased ISCU (zeige ISCU ELISA Kits) RNA levels were found in ~40% of tumors and this was significantly associated with HIF-1alpha (zeige HIF1A ELISA Kits) and CAIX (zeige CA9 ELISA Kits), but not MCT1 (zeige CMA1 ELISA Kits) or MCT4, over-expression.\nData show that metastasis-associated in colon cancer-1 (MACC1 (zeige MACC1 ELISA Kits)) and monocarboxylate transporter 1 (MCT1) are highly expressed in gastric cancer indicating poor prognosis.\nAA genotype of the MCT1 (zeige CMA1 ELISA Kits) T1470A polymorphism is over-represented in wrestlers compared with controls and is associated with lower blood lactate concentrations after 30-s Wingate Anaerobic test and during intermittent sprint tests in Japanese wrestlers\nMCT1 (zeige CMA1 ELISA Kits) and MCT4 expression levels were associated with worse prognosis and shorter overall survival.\nMCT1 (zeige CMA1 ELISA Kits) may be acting as an uptake transporter and MCT4 as an efflux system across the basolateral membrane for ferulic acid, and that this process is stimulated by butyric acid.\nAfter indirect co-culture, OP was increased in the BxPc-3 and Panc-1 cells; correspondingly, succinate dehydrogenase (zeige SDHA ELISA Kits), FH and MCT expression were increased. After the MCT1 (zeige CMA1 ELISA Kits)-specific inhibitor removed 'tumor-stromal' metabolic coupling, the migration and invasion abilities of the pancreatic cancer cells were decreased.\nData suggest that inhibition of mnocarboxylate transporters MCT1 (zeige CMA1 ELISA Kits) and MCT4 may have clinical relevance in pancreatic ductal adenocarcinoma (PDAC).\nResults found that MCT contributes to endothelial cell growth and tube formation via up-regulation of angiopoietin-1 (zeige ANGPT1 ELISA Kits) expression suggesting that MCT plays an important role in pancreatic cancer angiogenesis and tumor growth via activating the angiopoietin-1 (zeige ANGPT1 ELISA Kits) pathway.\nThe targeting of MCT1 (zeige CMA1 ELISA Kits) and PFKFB3 (zeige PFKFB3 ELISA Kits) regulated cell proliferation.\nIt was concluded that both MCT1 (zeige MCTS1 ELISA Kits) and CAII (zeige CA2 ELISA Kits) are involved in the homeostatic control of pH in skeletal muscle, both at rest and at the onset of exercise. The improved muscle function and resistance to fatigue in MCT1 (zeige MCTS1 ELISA Kits)(+/-) mice remain unexplained.\nExercise-induced changes in tumour LDH-B (zeige LDHB ELISA Kits) and MCT1 (zeige MCTS1 ELISA Kits) expression are modulated by oestrogen-related receptor alpha in breast cancer-bearing BALB/c mice\nChronic lactate administration after exercise increases MCT1 (zeige MCTS1 ELISA Kits) protein expression, which can be involved in the regulation of the observed increase in muscle glycogen (zeige GYS1 ELISA Kits) storage after exercise training.\nThis study showed that mouse MCT1 (zeige MCTS1 ELISA Kits), MCT2 (zeige SLC16A7 ELISA Kits), and MCT4 (zeige SLC16A3 ELISA Kits) are expressed in the PNS. While DRG neurons express MCT1 (zeige MCTS1 ELISA Kits), myelinating Schwann cells.\nThese data for the first time demonstrate that MCT1 (zeige MCTS1 ELISA Kits) is critical for regeneration of both sensory and motor axons in mice following sciatic nerve crush\nin Parkinson's disease, the levels of MCT1 (zeige MCTS1 ELISA Kits), MCT2 (zeige SLC16A7 ELISA Kits) and GLUT1 (zeige SLC2A1 ELISA Kits) is not changed following dopaminergic neurodegeneration\nresults suggest that a reduction in mitochondria is a result, rather than the cause, of the metabolic deficiency observed in Basigin-null mice, and likely occurs because of reduced metabolic activity in the absence of MCT1 (zeige MCTS1 ELISA Kits) expression.\nmiR (zeige MLXIP ELISA Kits)-29a, miR (zeige MLXIP ELISA Kits)-29b selectively target MCT1 (zeige MCTS1 ELISA Kits) 3'UTR (zeige UTS2R ELISA Kits) ; the miR (zeige MLXIP ELISA Kits)-29 isoforms are highly expressed in islets and contribute to silencing Mct1 (zeige MCTS1 ELISA Kits) in beta cells; miR (zeige MLXIP ELISA Kits)-29 isoforms contribute to beta-cell-specific silencing of the MCT1 (zeige MCTS1 ELISA Kits) transporter and may affect insulin (zeige INS ELISA Kits) release\nmonocarboxylate transporter 1 (MCT1), is highly enriched within oligodendroglia and disruption of this transporter produces axon damage and neuron loss in animal and cell culture models; in addition, this same transporter is reduced in patients with, and in mouse models of, amyotrophic lateral sclerosis, suggesting a role for oligodendroglial MCT1 (zeige MCTS1 ELISA Kits) in pathogenesis\nIt was shown that forced overexpression of MSlc16a1 in beta-cells replicates the key features of exercise-induced hyperinsulinism and highlights the importance of this transporter's absence from these cells for the normal control of insulin (zeige INS ELISA Kits) secretion.\nThis study confirmed age-dependent changes of MCT1 (zeige MCTS1 ELISA Kits) expression in the rumen epithelium of newborn calves and showed that its expression might be affected by liquid feed type.\nThese findings show that MCT 1 (zeige MCTS1 ELISA Kits) increases with the development of rumen function and also in adult animals MCT 1 (zeige MCTS1 ELISA Kits) may change with the feeding.\nThe expression and distribution of monocarboxylate transporter 1 along the gastrointestinal tract of calves suggest it may play a role in transport of short chain fatty acids and their metabolites.\nThe results show that monocarboxylate transporter 1 (MCT1) is a major route for short chain fatty acids (SCFA) efflux across the basolateral membrane of bovine large intestine and that it could play a role in the regulation of intracellular pH.\nThe protein encoded by this gene is a proton-linked monocarboxylate transporter that catalyzes the movement of many monocarboxylates, such as lactate and pyruvate, across the plasma membrane. Mutations in this gene are associated with erythrocyte lactate transporter defect. Alternatively spliced transcript variants have been found for this gene.\n, monocarboxylate transporter 1\n, monocarboxylate transporter 1a\n, solute carrier family 16 (monocarboxylic acid transporters), member 1\n, solute carrier family 16, member 1 (monocarboxylic acid transporter 1)\n, solute carrier family 16 member 1\n, monocarboxylate transporter 1-like\n, MCT 1\n, solute carrier 16 (monocarboxylic acid transporter), member 1", "domain": "chemistry", "round": 3} +{"url": "https://blogs.scientificamerican.com/news-blog/harder-than-a-diamond-survey-says-2009-02-19/", "date": "2023-09-23T16:58:21Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233506528.19/warc/CC-MAIN-20230923162848-20230923192848-00539.warc.gz", "language_score": 0.9158288240432739, "token_count": 369, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__20080563", "lang": "en", "text": "In addition to being the traditional token of marital intent, the diamond has long provided the—ahem—gold standard for super-hard materials. But physicists at Shanghai Jiao Tong University and at the University of Nevada, Las Vegas, say that two lesser-known materials, wurtzite boron nitride and lonsdaleite, are even harder.\nWurtzite boron nitride, the researchers calculate, resists indentation with 18 percent more fortitude than its glittering counterpart, whereas lonsdaleite, a hexagonal lattice of carbon atoms also known as hexagonal diamond, boasts indentation strength a whopping 58 percent greater than that of diamond. That would be a new record for hardness, the team claims in the study, published this month in the journal Physical Review Letters.\nThere's a catch to the claims, however: both materials are quite rare, and the assessment of their hardness was determined by calculations rather than physical demonstrations. Natalia Dubrovinskaia, a crystallographer at the University of Bayreuth in Germany, told the New Scientist that although the new work is important, it remains unproven until the materials can be physically isolated and tested.\nIn a 2004 open letter to the materials science community published in Nature Materials, Dubrovinskaia and an international team of colleagues cautioned against making claims of \"harder than diamond\" materials. The letter's authors specifically cite the pitfalls of basing such proclamations on simulated models of material structure, which might ignore real-life impurities or other subtleties: \"The relationship between the computed microscopic behavior of these materials and experimental measurements of their bulk properties, such as hardness, strength, toughness and abrasion resistance, is less than clear.\"\nDiamond photo by Mario Sarto via Wikimedia Commons", "domain": "chemistry", "round": 3} +{"url": "https://musliminsiders.com/bill-gates-backed-startup-to-remove-5000-tons-carbon-dioxide-by-this-year/", "date": "2024-04-13T22:48:46Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712296816853.44/warc/CC-MAIN-20240413211215-20240414001215-00444.warc.gz", "language_score": 0.9546344876289368, "token_count": 560, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__14752352", "lang": "en", "text": "Bill Gates’ Breakthrough Energy Ventures just supported the launch of a technology by Graphyte that could remove a significant number of greenhouse gases (GHG). Graphyte, the startup backed by Bill Gates, has just engineered a hybrid technology that combines engineering with natural photosynthesis processes to remove carbon dioxide from the atmosphere and store it underground.\nThey aimed to combat climate change by inventing those technologies. The startup’s project will remove 5,000 tons of carbon dioxide by this year and 50,000 by July 2024.\n“It’s important to understand that carbon removal is not an excuse to keep emitting or to slow down our transition to a clean energy economy—we need to keep innovating as fast as we can,” Gates wrote in his firm’s “State of the Transition 2023” report, released two days ago. “But it’s become clear that carbon removal will be a necessary tool to have in our toolkit.”\nGraphyte’s technology has its own unique approach that blends engineering with natural photosynthesis. It begins by collecting waste biomass, like wood residue or rice hulls, which is then dried and sterilized to prevent decomposition. After that, it is converted into carbon blocks, wrapped in a special polymer barrier, and stored underground, effectively locking the carbon away. This prevents carbon dioxide from being re-released.\nGraphyte called the carbon removal process “carbon casting,” which was first conceived by BEV partner Chris Rivest, who brought in co-founder and Chief Executive Officer Barclay Rogers to commercialize the technology and helm the startup.\nTheir technological efficiency and affordability are unlike those of other existing technologies. Graphyte claimed that its production cost only under $100 (RM 471) per ton of carbon dioxide, CO2, which is a portion of what current methods require. The benefit of these carbon blocks is that they are projected to last over a thousand years.\nGraphyte also faces hurdles while on this journey, namely securing enough buyers for carbon removal services. Other than that, they also have to maintain the durability of the carbon blocks, gaining regulatory and community support. Hence, Graphyte intends to use advanced monitoring systems, such as sensors and proprietary tracer systems, to overcome these obstacles and guarantee the efficiency and safety of carbon storage.\nWith Puro.earth as its carbon registry, Graphyte is taking steps towards independent verification of its carbon removal claims. This groundbreaking approach to carbon removal could mark a significant milestone in our fight against climate change. Graphyte transforms waste into a resource, effectively storing carbon and reducing atmospheric CO2, paving the way for a cleaner, more sustainable future.", "domain": "chemistry", "round": 3} +{"url": "http://leadsforagents.com/download/alkyl-polyglucosides-from-natural-origin-surfactants-to-prospective-delivery", "date": "2019-04-19T17:14:35Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-18/segments/1555578527865.32/warc/CC-MAIN-20190419161226-20190419183226-00519.warc.gz", "language_score": 0.8649123907089233, "token_count": 1127, "dump": "CC-MAIN-2019-18", "global_id": "webtext-fineweb__CC-MAIN-2019-18__0__163248600", "lang": "en", "text": "By Ivana Pantelic\nThe on-going ‘green’ pattern within the own care coupled with international environmental issues, position natural-origin, biodegradable and skin-friendly surfactants corresponding to alkyl polyglucosides (APGs) in excessive call for. After winning use in cosmetics, adequate information has been bought to welcome a few sugar emulsifiers into the sector of drug dosage. Alkyl Polyglucosides provides a finished compendium which publications a researcher from the APG-related preformulation phases to formula processing, together with the research of varied APG-stabilized structures epidermis functionality. This booklet introduces numerous APG representatives, their merits relating to sure traditional surfactants, physicochemical and interfacial houses, attainable interplay with frequent parts and various characterization innovations fundamental for the review of colloidal structures. the 1st bankruptcy introduces alkyl polyglucosides, by means of chapters on their homes, behaviour, an summary of the patent safeguard mechanisms and directions for filing patent purposes. eventually, a end surveys foreign patent functions regarding APGs.\n- introduces the sector of alkyl polyglucoside emulsifiers, directory all of the modern and newly synthesized APG emulsifiers\n- provides unique info on quite a few features of APG-based buildings\n- reveals power of APG-stabilized automobiles as potential supply structures utilizing a number of version medicines and beauty actives\n- includes an up to date overview of study performed within the box of APGs, facilitating destiny preformulation and formula reports for researchers\n- offers a concise and useful compendium of characterization concepts\nRead or Download Alkyl polyglucosides : from natural-origin surfactants to prospective delivery systems PDF\nSimilar forensic medicine books\nPandemic influenza is an instance of an rising pathogen which can have, and has had, severe public overall healthiness effects. Following 3 international pandemics within the final a hundred years and the new avian and swine influenza outbreaks, preparedness on nationwide and overseas scales is of important value.\nThis targeted books seems to be at a budget friendly, speedy and actual technique of facial reconstruction--from segmented, decomposed, or skeletal remains--using computer-graphic and computational ability. Computer-Graphic Facial Reconstruction is designed as a invaluable source for these scientists designing new learn tasks and protocols, in addition to a realistic instruction manual of tools and strategies for medico-legal practitioners who truly establish the faceless sufferers of crime.\nThis short highlights advances in DNA applied sciences and their wider purposes. DNA is the resource of existence and has been studied on the grounds that a new release, yet little or no is called but. a number of subtle applied sciences of the present period have laid their foundations at the precept of DNA established mechanisms.\n- Forensic Pharmacology (Inside Forensic Science)\n- Advances in Forensic Applications of Mass Spectrometry\n- Clarke's Isolation and Identification of Drugs: In Pharmaceuticals, Body Fluids and Post Mortem Material\n- HPLC Methods on Drug Analysis\nAdditional info for Alkyl polyglucosides : from natural-origin surfactants to prospective delivery systems\n2011). Aqueous and lipid phases were prepared separately. Solid lipid was melted at 75 °C to prevent the recrystallization of lipids during the process. Hydrophilic surfactants and water were heated to the same temperature and added to the melted lipid phase. The mixture was dispersed with a high-shear mixer (Ultra Turrax, IKA Staufen, Germany) for 30 s at 8000 rpm and subjected to high-pressure homogenization, applying a pressure of 500 bar. The homogenizer (Micron LAB 40, APV Deutschland GmbH, Germany) was equipped with a water jacket for temperature control.\nCloud point phenomena in the phase behavior of alkyl polyglucosides in water. Langmuir 1993; 9: 3375–84. Balzer D, Luders H, eds. , 2000. British Pharmacopoeia 2009 (BP 2009), British Pharmacopoeia Commission, The Stationery Office, London: UK, 2009. 48 Behind the Alkyl Polyglucoside-based structures Corrigan OI, Healy AM. Surfactants in pharmaceutical products and systems. In: Swarbrick J, ed. Encyclopedia of pharmaceutical technology. , 2002. Deutsche Arzneibuch 2006 (DAB 2006), German Federal Institute for Drugs and Medicines, Bonn, 2006.\nHPC Focus Surf 2008; 2: 18–22. Hill K, von Rybinski W, Stoll G, eds. Alkyl Polyglycosides: Technology, Properties and Applications. Weinheim: VCH, 1997. Hoffmann B, Platz G. Phase and aggregation behaviour of alkylglycosides. Curr Opin Colloid Interf Sci 2001; 6: 171–7. Holmberg K. Natural surfactants. Curr Opin Colloid Interface Sci 2001; 6: 148–59. Iglauer S, Wu Y, Shuler P, Yongchun T, Goddard III A. Alkyl polyglycoside surfactant–alcohol cosolvent formulations for improved oil recovery. Colloids Surf A Physicochem Eng Asp 2009; 339: 48–59.", "domain": "chemistry", "round": 3} +{"url": "https://www.pi4kinhibitor.com/2023/03/22/10093/", "date": "2024-02-24T13:39:39Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707947474533.12/warc/CC-MAIN-20240224112548-20240224142548-00510.warc.gz", "language_score": 0.9244474172592163, "token_count": 783, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__64642053", "lang": "en", "text": "Microbiome. D3 Receptor custom synthesis Nonetheless, the upregulation of CYP and UGT genes suggests that a robust ERα supplier detoxification response is induced by the entomopathogen, indicating the presence of totally free radicals. In spite of the weak upregulation of Nos, the production of NO by hemocytes to facilitate an immune response in the gut is nevertheless possible68,69. ROS and RNS are beneficial as an instant response against stressors, but their persistence is probably to damage host cells70. Accordingly, they’re removed by protective antioxidant enzymes such as catalase and detoxification enzymes for example CYPs and UGTs, which bind molecular oxygen along with other cytotoxic compounds to straight kind non-toxic water or water-soluble solutions in insects and mammals41,71. We observed the powerful upregulation of catalase following the induction of Nos, suggesting the part of catalase would be to clear up RNS produced by NOS. Further experiments are needed to measure cost-free radical levels and to identify which compounds are removed by catalase. The catalase gene was moderately upregulated in response to P. entomophila, coincidingScientific Reports | Vol:.(1234567890) (2021) 11:6819 | https://doi.org/10.1038/s41598-021-86293-0www.nature.com/scientificreports/with the minimal induction of Nos and Duox. In contrast, UGT-2C1 and UGT-2B15 were induced more strongly by the entomopathogen than the pesticides. Most of the CYP genes have been moderately induced, but cyp9e2 was upregulated 1000,000-fold soon after 1 h for all stressors, indicating a detoxification function that is not restricted to bacterial infections72. Indeed, CYP9E2 has been shown to metabolize thiacloprid effectively in honeybees, whereas other CYPs cannot fulfil this function73. Furthermore, a recent analysis of your sublethal effects of air pollution, a chemically complex stressor, also showed that cyp9e2 was strongly upregulated in honeybee heart tissue74. Our data indicate that biotic and abiotic stressors induce the preferred expression of genes encoding UGTs and catalase, respectively, whereas CYP9E2 appears to fulfil a universal detoxification function. The ability of dimoxystrobin to disrupt the mitochondrial respiratory chain in fungi may possibly clarify the specifically powerful induction of cyp9e2 ( ten,000-fold) by this xenobiotic. Interestingly, our gene expression information have been not homogeneous at the various sampling time points, possibly reflecting the broadly spaced sampling intervals but additionally the truth that our insects had been collected from a working hive in lieu of synchronously bred inside the laboratory. Age and developmental stage might influence the potency of strain responses and immunity in bees43,44. Irrespective of the stressor, the main stress response of eukaryotic cells relies around the immediate activation of defense signaling molecules for example ROS757. Even so, the production of these volatile compounds in response to xenobiotics, followed by their elimination, is really a dynamic cell state that may possibly also explain the results of our time course experiments. In addition, our gene expression data clearly indicate the induction of AMP genes in response to strain. In contrast towards the raise in AMP gene expression we observed, previous research in honeybees and masonbees showed that low doses of neonicotinoids trigger the depletion of hemocytes, resulting in restricted antimicrobial activity780. Furthermore, we did not observe substantial upregulation ( 10 for only single timepoints) in the Toll inhibitor cactus-2 following xenobiotic exposure. Assumably, the.", "domain": "chemistry", "round": 3} +{"url": "https://experts.umn.edu/en/publications/cationic-micelles-outperform-linear-polymers-for-delivery-of-anti", "date": "2023-01-28T01:44:36Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-06/segments/1674764499468.22/warc/CC-MAIN-20230127231443-20230128021443-00373.warc.gz", "language_score": 0.9101382493972778, "token_count": 701, "dump": "CC-MAIN-2023-06", "global_id": "webtext-fineweb__CC-MAIN-2023-06__0__285509553", "lang": "en", "text": "Projects per year\nAntisense oligonucleotides (ASOs) are an important emerging therapeutic; however, they struggle to enter cells without a delivery vehicle, such as a cationic polymer. To understand the role of polymer architecture for ASO delivery, five linear polymers and five diblock polymers (capable of self-assembly into micelles) were synthesized with varying cationic groups. After complexation of each polymer/micelle with ASO, it was found that less bulky cationic moieties transfected the ASO more effectively. Interestingly, however the ASO internalization trend was the opposite of the transfection trend for cationic moiety, indicating internalization is not the major factor in determining transfection efficiency for this series. Micelleplexes (micelle-ASO complexes) generally enable higher transfection efficacy as compared to polyplexes (linear polymer-ASO complexes). Additionally, the order of addition of cells and complexes was explored. Linear polyplexes showed better transfection efficiency in adhered cells, whereas micelleplexes delivered the ASO more efficiently when the cells and micelleplexes were added simultaneously. This phenomenon may be due to increased cell-complex interactions as micelleplexes have increased colloidal stability compared to polyplexes. These findings emphasize the importance of polymer composition and architecture in governing the cellular interactions necessary for transfection, thus allowing advancement in the design principles for nonviral nucleic acid delivery formulations.\nBibliographical noteFunding Information:\nWe sincerely thank Genentech for funding of this work. M.G.H. acknowledges the support from the National Science Foundation Graduate Research Fellowship Program (DGE-1839286) and the University of Minnesota Doctoral Dissertation Fellowship. This work was also supported by the National Science Foundation (NSF) through the University of Minnesota MRSEC under award DMR2011401. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the authors and do not necessarily reflect the views of the National Science Foundation. The authors would like to express their gratitude toward Dr. Karthik Nagaoudi and Dr. Apoorva Sarode from Genentech for numerous helpful discussions. We would also like to thank Kaelyn Gasvoda, Dr. Eben Alsberg, Dr. Qiaobing Xu, Liu Yang for helpful discussions regarding ASO knockdown assay development and in particular Dr. Eben Alsberg for donating the deGFP HEK cells to our laboratory. We are grateful to Hannah Lembke for her help with statistical analysis. Parts of this work’s figures were adapted or created with BioRender.\n© 2022 American Chemical Society. All rights reserved.\nHow much support was provided by MRSEC?\nPubMed: MeSH publication types\n- Journal Article\nFingerprintDive into the research topics of 'Cationic Micelles Outperform Linear Polymers for Delivery of Antisense Oligonucleotides in Serum: An Exploration of Polymer Architecture, Cationic Moieties, and Cell Addition Order'. Together they form a unique fingerprint.\n- 2 Active\n9/1/20 → 8/31/26\nProject: Research project", "domain": "chemistry", "round": 3} +{"url": "https://m.scirp.org/papers/17039", "date": "2020-01-17T21:25:56Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-05/segments/1579250591234.15/warc/CC-MAIN-20200117205732-20200117233732-00171.warc.gz", "language_score": 0.7470754384994507, "token_count": 1735, "dump": "CC-MAIN-2020-05", "global_id": "webtext-fineweb__CC-MAIN-2020-05__0__92752825", "lang": "en", "text": "ABSTRACT The present study reports the formation of ultrafine hard particles of nanocomposite WC with different additions of ZrO2 powders (0.5 - 20 vol.%). The initial mixed powders of WC with the desired ZrO2 concentrations were mechanically mixed for 360 ks (end-product) under argon gas atmosphere at room temperature, using high energy ball mill. The end-product consists of average grain size of about 17 nm in diameter. The obtained nanocomposite powders were consolidated into fully dense compact, using spark plasma sintering (SPS) technique in vacuum. The experimental results revealed that the consolidation step, which was conducted at 1673 K with uniaxial pressure ranging from 19.6 to 38.2 MPa for short time (0.18 ks), does not lead to dramatic grain growth in the powders so that the consolidated nanocomposite bulk objects maintain their nanocrystalline behavior, being fine grains with an average size of 63 nm in diameter. The relative densities of consolidated nanocomposite WC/ZrO2 materials increase from 99.1% for WC-0.5% ZrO2 to 99.93% for WC-20% ZrO2. The indentation fracture toughness of the composites can be tailored between 7.31 and 19.46 MPa/m1/2 by controlling the volume fraction of ZrO2 matrix from 0.5% to 20%. The results show that the Poisson’s ratio increased monotonically with increasing the ZrO2 concentrations to get a maximum value of 0.268 for WC-20% ZrO2. In the whole range of ZrO2 concentrations (0.5 - 20 vol.%), high hardness values (20.73 to 22.83 GPa) were achieved. The Young’s modulus tends to decrease with increasing the volume fraction of the ZrO2 matrix to reach a minimum value of 583.2 GPa for WC-20% ZrO2. These hard and tough WC/ZrO2 nanocomposites are proposed to be employed as higher abrasive-wear resistant materials.\nCite this paper\nM. El-Eskandarany, H. Soliman and M. Omoric, \"Influence of Nanocrystalline ZrO2 Additives on the Fracture Toughness and Hardness of Spark Plasma Activated Sintered WC/ZrO2 Nanocomposites Obtained by Mechanical Mixing Method,\" Open Journal of Composite Materials, Vol. 2 No. 1, 2012, pp. 1-7. doi: 10.4236/ojcm.2012.21001.\n M. S. El-Eskandarany, “Mechanical Alloying for Fabrication of Advanced Engineering Materials,” William Andrew, New York, 2001, p. 45.\n T. Venkateswaran, D. Sarkar and B. Basu, “Tribological Properties of WC-ZrO2 Nanocomposites,” Journal of the American Ceramic Society, Vol. 88, No. 3, 2005, pp. 691- 697. doi:10.1111/j.1551-2916.2005.00129.x\n M. S. El-Eskandarany, “Fabrication of Nanocrystalline WC and Nanocomposite WC-MgO Refractory Materials at Room Temperature,” Journal of Alloys and Compounds, Vol. 296, No. 1-2, 2000, pp. 175-182.\n M. S. El-Eskandarany, A. A. Mahday, H. A. Ahmed and A. H. Amer, “Synthesis and Characterizations of Ball- Milled Nanocrystalline WC and Nanocomposite WC-Co Powders and Subsequent Consolidations,” Journal of Alloys and Compounds, Vol. 312, No. 1-2, 2000, pp. 315- 325. doi:10.1016/S0925-8388(00)01155-5\n H.-C. Kim, I.-J. Shon, J.-K. Yoon and J.-M. Doh, “Consolidation of Ultra Fine WC and WC-Co Hard Materials by Pulsed Current Activated Sintering and Its Mechanical Properties,” International Journal of Refractory Metals & Hard Materials, Vol. 25, No. 1, 2007, pp. 46-52.\n M. Sherif El-Eskandarany, M. Omori, T. Hirai, T. J. Konno, K. Sumiyama and K. Suzuki, “Synthesizing of Nanocomposite WC/MgO powders by Mechanical Solid- State Reduction and Subsequent Plasma-Activated Sintering,” Metallurgical and Materials Transactions A, Vol. 32, No. 1, 2001, pp. 157-164.\n B. Basu, T. Venkateswaran and D. Sakar, “Pressureless Sintering and Tribological Properties of WC-ZrO2 Composites,” Journal of the European Ceramic Society, Vol. 25, No. 9, 2005, pp. 1603-1610.\n M. S. El-Eskandarany, “Fabrication and Characterizations of New Nanocomposite WC/Al2O3 Materials by Room Temperature Ball Milling and Subsequent Consolidation,” Journal of Alloys and Compounds, Vol. 391, No. 1-2, 2005, pp. 228-235. doi:10.1016/j.jallcom.2004.08.064\n M. S. El-Eskandarany, M. Omori and A. Inoue, “Solid- State Synthesis of New Glassy Co65Ti20W15 Alloy Powders and Subsequent Densification into a Fully Dense Bulk Glass,” Journal of Materials Research, Vol. 20, No. 10, 2005, pp. 2845-2853. doi:10.1557/JMR.2005.0344\n G. R. Anstis, P. Chantikul, B. R. Lawn and D. B. Marshall, “A Critical Evaluation of Indentation Techniques for Measuring Fracture Toughness: I, Direct Crack Meas- urements,” Journal of the American Ceramic Society, Vol. 64, No. 9, 1981, pp. 533-538.\n B. Basu, J. Vleugels and O. Van-der Biest, “Processing and Mechanical Properties of ZrO2-TiB2 Composites,” Journal of the European Ceramic Society, Vol. 25, No. 16, 2005, pp. 3629-3637.\n H. Miyazaki, Yu-ichi Yoshizawa and K. Hirao, “Effect of the Volume Ratio of Zirconia and Alumina on the Mechanical Properties of Fibrous Zirconia/Alumina Bi-Phase Composites Prepared by Co-Extrusion,” Journal of European Ceramics Society, Vol. 26, No. 16, 2006, pp. 3539-3546.\n R. C. Garvie, R. H. Hannink and R. T. Pascoe, “Ceramic steel?” Nature, Vol. 258, No. 5537, 1975, pp. 703-704.\n M. S. El-Eskandarany, M. Omori, M. Ishikuro, T. J. Kon- no, K. Takada, K. Sumiyama, T. Hirai and K. Suzuki, “Synthesis of Full-Density Nanocrystalline Tungsten Carbide by Reduction of Tungstic Oxide at Room Temperature,” Metallurgical and Materials Transactions A, Vol. 27A, No. 12, 1996, pp. 4210-4213.", "domain": "chemistry", "round": 3} +{"url": "https://jgi.doe.gov/publication/the-complete-genome-sequence-of-fibrobacter-succinogenes-s85-reveals-a-cellulolytic-and-metabolic-specialist/", "date": "2023-12-06T23:58:25Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100626.1/warc/CC-MAIN-20231206230347-20231207020347-00322.warc.gz", "language_score": 0.927944004535675, "token_count": 407, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__312413637", "lang": "en", "text": "Fibrobacter succinogenes is an important member of the rumen microbial community that converts plant biomass into nutrients usable by its host. This bacterium, which is also one of only two cultivated species in its phylum, is an efficient and prolific degrader of cellulose. Specifically, it has a particularly high activity against crystalline cellulose that requires close physical contact with this substrate. However, unlike other known cellulolytic microbes, it does not degrade cellulose using a cellulosome or by producing high extracellular titers of cellulase enzymes. To better understand the biology of F. succinogenes, we sequenced the genome of the type strain S85 to completion. A total of 3,085 open reading frames were predicted from its 3.84 Mbp genome. Analysis of sequences predicted to encode for carbohydrate-degrading enzymes revealed an unusually high number of genes that were classified into 49 different families of glycoside hydrolases, carbohydrate binding modules (CBMs), carbohydrate esterases, and polysaccharide lyases. Of the 31 identified cellulases, none contain CBMs in families 1, 2, and 3, typically associated with crystalline cellulose degradation. Polysaccharide hydrolysis and utilization assays showed that F. succinogenes was able to hydrolyze a number of polysaccharides, but could only utilize the hydrolytic products of cellulose. This suggests that F. succinogenes uses its array of hemicellulose-degrading enzymes to remove hemicelluloses to gain access to cellulose. This is reflected in its genome, as F. succinogenes lacks many of the genes necessary to transport and metabolize the hydrolytic products of non-cellulose polysaccharides. The F. succinogenes genome reveals a bacterium that specializes in cellulose as its sole energy source, and provides insight into a novel strategy for cellulose degradation.", "domain": "chemistry", "round": 3} +{"url": "https://pubmed.ncbi.nlm.nih.gov/28993647/", "date": "2020-09-18T18:34:32Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-40/segments/1600400188049.8/warc/CC-MAIN-20200918155203-20200918185203-00735.warc.gz", "language_score": 0.9416810870170593, "token_count": 324, "dump": "CC-MAIN-2020-40", "global_id": "webtext-fineweb__CC-MAIN-2020-40__0__25269021", "lang": "en", "text": "Kidney plays a key role in the elimination and reabsorption of drugs and nutrients, however in vitro methods to evaluate renal disposition are limited. In the present study, we investigated usefulness of isolated kidney slice, which had been used for transport only at basolateral membrane of tubular epithelial cells, for evaluation of apical membrane transporters. As transporters that are easy to discriminate between apical and basolateral transports, apical membrane specific and sodium-dependent transporters (SGLTs and OCTNs) and pH-dependent transporters (PEPTs) are selected. Uptake of ergothioneine, carnitine and methyl-α-D-glucopyranoside, which are substrates of apical Octn1, Octn2, and Sglt1/2, respectively, by mice kidney slices showed clear Na+ dependence and reduction by selective inhibitors. In addition, sodium dependence of ergothioneine uptake was negligible in the kidney slice from Octn1-gene deficient mice. Moreover, uptake of PepT1/2 substrate glycyl-sarcosine, was higher than that in the presence of glycyl-leucine, a non-specific Pept inhibitor. The K m and IC 50 values for substrates and inhibitors of each transporter were mostly comparable to those obtained in transporter-transfected cells. In conclusion, it was demonstrated that kidney slices are promising tool to study transporters expressed at the apical membranes as well as basolateral membranes of kidney tubular epithelial cells.", "domain": "chemistry", "round": 3} +{"url": "https://www.corrosionpedia.com/definition/1381/nondestructive-evaluation-nde", "date": "2023-09-25T17:32:45Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233509023.57/warc/CC-MAIN-20230925151539-20230925181539-00868.warc.gz", "language_score": 0.8986797332763672, "token_count": 449, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__145618479", "lang": "en", "text": "What Does Nondestructive Evaluation (NDE) Mean?\nNondestructive evaluation (NDE) is an interdisciplinary field of study which is concerned with the development of analysis techniques and measurement technologies for the quantitative characterization of materials, tissues and structures by noninvasive means.\nSince NDE does not permanently alter the article being inspected, it is a highly valuable technique that can save both money and time in product evaluation, troubleshooting and research.\nTraditional NDE areas of applications include:\n- Flaw detection\n- Structural health monitoring\n- Materials characterization\nNondestructive evaluation is also known as nondestructive testing (NDT), nondestructive inspection (NDI) and nondestructive examination (NDE).\nCorrosionpedia Explains Nondestructive Evaluation (NDE)\nSome uses of NDE include:\n- Flaw detection and evaluation\n- Leak detection\n- Location determination\n- Dimensional measurements\n- Structure and microstructure characterization\n- Estimation of mechanical and physical properties\n- Stress (strain) and dynamic response measurements\n- Material sorting and chemical composition determination\nCommon NDE methods include:\n- Ultrasonic - Used to locate surface and subsurface defects in many materials including metals, plastics and wood\n- Magnetic-particle - Used to inspect ferromagnetic materials (those that can be magnetized) for defects\n- Liquid penetrant - Used to locate cracks, porosity and other defects\n- Radiographic - Used to inspect almost any material for surface and subsurface defects\n- Eddy-current - Used to detect surface and near-surface flaws in conductive materials, such as metals\nNo single NDE method will work for all flaw detection or measurement applications. Each method has advantages and disadvantages.\nThere are NDE applications at almost any stage in the production or life cycle of a component, such as:\n- Assisting in product development\n- Screening or sorting incoming materials\n- Monitoring, improving or controlling manufacturing processes\n- Verifying proper processing, such as heat treating\n- Verifying proper assembly\n- Inspecting for in-service damage", "domain": "chemistry", "round": 3} +{"url": "https://scholarsmine.mst.edu/min_nuceng_facwork/1496/", "date": "2021-06-20T16:26:28Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-25/segments/1623488249738.50/warc/CC-MAIN-20210620144819-20210620174819-00320.warc.gz", "language_score": 0.8920156955718994, "token_count": 520, "dump": "CC-MAIN-2021-25", "global_id": "webtext-fineweb__CC-MAIN-2021-25__0__202026328", "lang": "en", "text": "Characterization of Coal Particles Wettability in Surfactant Solution by using Four Laboratory Static Tests\nCoal dust is a health threat to underground coal miners, and the current common practice is to use water spray to control it. The coal wettability plays a significant role in studying the effectiveness of coal dust suppression, and the addition of surfactant to water can greatly improve the coal wettability. The aim of this paper is to evaluate the reliability of four methods that are commonly used to quantify the coal wettability in presence of surfactant, they are the sessile drop measurement, the sink test, the capillary rise test and the drop penetration test. The advantages and disadvantages of these four methods were detailed. The results indicated that the sink test is the most reliable method in terms of its simplest operation and the highest accuracy. It also has the ability to quantitatively compare the wettability of different coal particle sizes, which the other three methods failed to identify. The addition of surfactant resulted in smaller contact angles, less sink time, less drop penetration time and more capillary rise weight gains compared with using water only, which indicated that the coal wettability is improved by surfactants. Of the two studied surfactants, SDBS performed better than SDS. This study provided a guideline on both evaluation method and surfactant selection when studying the wettability of coal particles.\nY. Chen et al., \"Characterization of Coal Particles Wettability in Surfactant Solution by using Four Laboratory Static Tests,\" Colloids and Surfaces A: Physicochemical and Engineering Aspects, vol. 567, pp. 304-312, Elsevier, Apr 2019.\nThe definitive version is available at https://doi.org/10.1016/j.colsurfa.2019.01.068\nKeywords and Phrases\nCoal; Contact angle; Drops; Health risks; Miners; Surface active agents; Testing; Wetting; Wetting agents; Capillary rise; Characterization of coal; Coal wettability; Different coals; Drop penetration; Dust suppression; Reliable methods; Surfactant solution; Coal dust; Coal; Surfactant; Water; Accuracy; Article; Laboratory test; Particle size; Priority journal; Quantitative analysis; Reliability; Wettability; Coal dust suppression; Sink test; Surfactant\nInternational Standard Serial Number (ISSN)\nArticle - Journal\n© 2019 Elsevier, All rights reserved.\n01 Apr 2019", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/donkey-rat-igg-hl-dylight-550-preadsorbed-ab102261.html", "date": "2020-11-24T01:54:47Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-50/segments/1606141169606.2/warc/CC-MAIN-20201124000351-20201124030351-00712.warc.gz", "language_score": 0.8036023378372192, "token_count": 811, "dump": "CC-MAIN-2020-50", "global_id": "webtext-fineweb__CC-MAIN-2020-50__0__21272191", "lang": "en", "text": "Key features and details\n- Donkey polyclonal Secondary Antibody to Rat IgG - H&L (DyLight® 550), pre-adsorbed\n- Conjugation: DyLight® 550. Ex: 562nm, Em: 576nm\n- Host species: Donkey\n- Isotype: IgG\n- Suitable for: Flow Cyt, ICC, IHC-P\nProduct nameDonkey Anti-Rat IgG H&L (DyLight® 550) preadsorbed\nSee all IgG secondary antibodies\nDescriptionDonkey polyclonal Secondary Antibody to Rat IgG - H&L (DyLight® 550), pre-adsorbed\nSpecificityBy immunoelectrophoresis and ELISA this antibody reacts specifically with rat IgG and with light chains common to other rat immunoglobulins. No antibody was detected against non-immunoglobulin serum proteins. Less than 1% cross reactivity to bovine, chicken, goat, horse, human, mouse, rabbit and sheep IgG was detected. This antibody may cross react with IgG from other species.\nTested applicationsSuitable for: Flow Cyt, ICC, IHC-Pmore details\nChicken, Cow, Goat, Horse, Human, Mouse, Rabbit, SheepTo ensure minimal cross-reactivity, the antibody has been pre-adsorbed with serum proteins from the following species.more details\nConjugationDyLight® 550. Ex: 562nm, Em: 576nm\nStorage instructionsShipped at 4°C. Store at +4°C.\nStorage bufferpH: 6.8\nPreservative: 0.09% Sodium azide\nConstituents: 0.2% BSA, PBS\nConcentration information loading...\nPurityImmunogen affinity purified\nPurification notesAntiserum was cross adsorbed using bovine, chicken, goat, horse, human, mouse, rabbit and sheep immunosorbents to remove cross reactive antibodies. This antibody was isolated by affinity chromatography using antigen coupled to agarose beads and conjugated to DyLight® 550.\nGeneral notesDyLight® 550 replaces DyLight® 549.\nOur Abpromise guarantee covers the use of ab102261 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\n|Flow Cyt||1/50 - 1/200.|\n|ICC||1/50 - 1/500.|\n|IHC-P||1/50 - 1/500.\nDyLight® 550 replaces DyLight® 549. The DyLight® 550 excitation is 562nm and the emission is 576nm. DyLight® 550 provides the same orange-to-red fluorescence and photostability as the DyLight® 549 dye. Please refer to the vial in order to check whether the product you received is DyLight® 549 or DyLight® 550. This information however will have no impact on your experiments. For more information please refer to DyLight® 550.\nTo our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.\nab102261 has been referenced in 2 publications.\n- Hess DL et al. Perivascular cell-specific knockout of the stem cell pluripotency gene Oct4 inhibits angiogenesis. Nat Commun 10:967 (2019). PubMed: 30814500\n- Durgin BG et al. Smooth muscle cell-specific deletion of Col15a1 unexpectedly leads to impaired development of advanced atherosclerotic lesions. Am J Physiol Heart Circ Physiol 312:H943-H958 (2017). PubMed: 28283548", "domain": "chemistry", "round": 3} +{"url": "http://ecocompositos.pt/en/areas-de-negocio/espacos-verdes/fertilizantes", "date": "2023-12-02T18:13:01Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100448.65/warc/CC-MAIN-20231202172159-20231202202159-00852.warc.gz", "language_score": 0.9023164510726929, "token_count": 252, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__33007306", "lang": "en", "text": "Fertilizers are chemical compounds used in agriculture to boost the quantity of nutrients in the soil and, consequently, achieve a gain in productivity. Nowadays they are widely used but usually have a negative impact on the enviromnent.\nMIVENA's fertilizers allow one to minimize the impact on the enviromnent while not compromising with top notch quality.\nWith adequate solutions, using technologies for the study of soil and climate, culture type, MIVENA's maxim is to achieve the production of a \"smart fertilizer\". These fertilizers are distinguished by the slow or controlled release of nutrients, maximizing thus their result with less pollution.\nWe distribute fertilizes which are developed specifically for Golf Courses, public gardens, fruit and vegetable production, tree nurseries, bulbs and chrysanthemums.\nWith MIVENA you can find to obtain an optimal solution to achieve a maximum level of rentability with your cultures, with less enviromnental pollution.\nMIVENA presents a fertilization program adapted to your specific needs after a study of the soil and culture type. MIVENA fertilizers are based in a technology that allows the slow and controlled liberation of nutrients, boosting productivity with less harm to nature", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/gmppb-antibody-ab238845.html", "date": "2020-09-30T22:07:08Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-40/segments/1600402128649.98/warc/CC-MAIN-20200930204041-20200930234041-00531.warc.gz", "language_score": 0.6912955641746521, "token_count": 450, "dump": "CC-MAIN-2020-40", "global_id": "webtext-fineweb__CC-MAIN-2020-40__0__66415215", "lang": "en", "text": "Key features and details\n- Rabbit polyclonal to GMPPB\n- Suitable for: IHC-P\n- Reacts with: Human\n- Isotype: IgG\nProduct nameAnti-GMPPB antibody\nSee all GMPPB primary antibodies\nDescriptionRabbit polyclonal to GMPPB\nTested applicationsSuitable for: IHC-Pmore details\nSpecies reactivityReacts with: Human\nRecombinant fragment corresponding to Human GMPPB aa 61-360.\nDatabase link: Q9Y5P6\n- IHC-P: Human prostate cancer and adrenal gland tissue.\nStorage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.\nStorage bufferpH: 7.40\nConstituents: 50% Glycerol, PBS, 0.03% Proclin 300\nConcentration information loading...\nPurityProtein G purified\nPurification notesPurity greater than 95%.\nOur Abpromise guarantee covers the use of ab238845 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\n|IHC-P||1/20 - 1/200.|\nPathwayNucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1.\nSequence similaritiesBelongs to the transferase hexapeptide repeat family.\n- Information by UniProt\n- GDP mannose pyrophosphorylase B antibody\n- GDP-mannose pyrophosphorylase B antibody\n- GMPPB antibody\nTo our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.\nab238845 has not yet been referenced specifically in any publications.", "domain": "chemistry", "round": 3} +{"url": "https://thno.org/v11p9470", "date": "2022-05-18T16:35:24Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-21/segments/1652662522284.20/warc/CC-MAIN-20220518151003-20220518181003-00514.warc.gz", "language_score": 0.8475748896598816, "token_count": 501, "dump": "CC-MAIN-2022-21", "global_id": "webtext-fineweb__CC-MAIN-2022-21__0__323692160", "lang": "en", "text": "Theranostics 2021; 11(19):9470-9491. doi:10.7150/thno.62984 This issue\n1. State Key Laboratory of Silkworm Genome Biology, School of Materials and Energy, Southwest University, Chongqing 400715, China.\n2. Chongqing Key Laboratory of Ultrasound Molecular Imaging, Institute of Ultrasound Imaging, Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, China.\nIntroduction: An imbalance in redox homeostasis consistently inhibits tumor cell proliferation and further causes tumor regression. Thus, synchronous glutaminolysis inhibition and intracellular reactive oxygen (ROS) accumulation cause severe redox dyshomeostasis, which may potentially become a new therapeutic strategy to effectively combat cancer.\nMethods: Mitochondrial-targeting liposomal nanoparticles (abbreviated MLipRIR NPs) are synthesized by the encapsulation of R162 (inhibitor of glutamate dehydrogenase 1 [GDH1]) and IR780 (a hydrophobic sonosensitizer) within the lipid bilayer, which are exploited for ultrasound (US)-activated tumor dyshomeostasis therapy reinforced by immunogenic cell death (ICD).\nResults: R162 released from MLipRIR NPs disrupts the glutaminolysis pathway in mitochondria, resulting in downregulated enzymatic activity of glutathione peroxidase (GPx). In addition, loaded IR780 can generate high levels of ROS under US irradiation, which not only interrupts mitochondrial respiration to induce apoptosis but also consumes local glutathione (GSH). GSH depletion accompanied by GPx deactivation causes severe ferroptosis of tumor cells through the accumulation of lipid peroxides. Such intracellular redox dyshomeostasis effectively triggers immunogenic cell death (ICD), which can activate antitumor immunity for the suppression of both primary and distant tumors with the aid of immune checkpoint blockade.\nConclusions: Taking advantage of multimodal imaging for therapy guidance, this nanoplatform may potentiate systemic tumor eradication with high certainty. Taken together, this state-of-the-art paradigm may provide useful insights for cancer management by disrupting redox homeostasis.\nKeywords: drug delivery, liposome, targeting, redox dyshomeostasis, sonodynamic therapy", "domain": "chemistry", "round": 3} +{"url": "https://www.philips.co.uk/c-e/ho/articles/kitchen-appliances/kitchen-and-cooking-tips/a-guide-to-cleaning-and-descaling-the-kettle.html", "date": "2023-12-11T20:06:00Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679516047.98/warc/CC-MAIN-20231211174901-20231211204901-00716.warc.gz", "language_score": 0.8762170076370239, "token_count": 301, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__58653198", "lang": "en", "text": "How to descale the kettle with vinegar: step-by-step tutorial\nCleaning the kettle with vinegar should give you a really deep clean, as the acid help to break down the deposits. When using a natural kettle descaler like this for the first time, it’s worth doing a quick check first that your particular model will respond well to this particular method to get rid of limescale in kettle. Have a read of the manufacturer’s instructions to be sure, and then follow these steps:\n- Mix a solution of equal parts white vinegar and water.\n- Fill the kettle to half capacity.\n- Bring the kettle to a boil. If it doesn’t have an automatic switch-off, turn it off.\n- Allow the solution to sit for at least 30 minutes (you can even leave it overnight).\n- Pour the liquid away, and rinse the kettle with fresh, clean, cold water.\n- Fill the kettle with fresh water and bring it to a boil.\n- Pour the water away.\n- Repeat steps 6 and 7 twice, in order to remove any lingering vinegar residue.\nIf you want a home remedy for limescale in a kettle, but you don’t have any white vinegar to hand, you can use other kitchen cupboard staples instead. You could try filling the kettle three quarters full with water and adding one tablespoon of bicarbonate of soda, then following steps 3-8 above.", "domain": "chemistry", "round": 3} +{"url": "https://www.astm.org/Standards/C240.htm", "date": "2021-10-24T00:47:45Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-43/segments/1634323585828.15/warc/CC-MAIN-20211023224247-20211024014247-00526.warc.gz", "language_score": 0.806098461151123, "token_count": 828, "dump": "CC-MAIN-2021-43", "global_id": "webtext-fineweb__CC-MAIN-2021-43__0__75780939", "lang": "en", "text": "| ||Format||Pages||Price|| |\n|4||$48.00||  ADD TO CART|\n|Hardcopy (shipping and handling)||4||$48.00||  ADD TO CART|\n|Standard + Redline PDF Bundle||8||$56.00||  ADD TO CART|\nSignificance and Use\n4.1 From a general standpoint, these test methods outline the particular points which have to be taken into account when applying ASTM standard test methods to the case of cellular glass insulating block.\n1.1 These test methods cover the testing of cellular glass insulation block for density, water absorption, compressive strength, flexural strength at ambient temperature; preparation for chemical analysis; and thermal conductivity measurements.\n1.2 The values stated in inch-pound units are to be regarded as standard. The values given in parentheses are mathematical conversions to SI units that are provided for information only and are not considered standard.\n1.3 This standard does not purport to address all of the safety concerns, if any, associated with its use. It is the responsibility of the user of this standard to establish appropriate safety, health, and environmental practices and determine the applicability of regulatory limitations prior to use.\n1.4 This international standard was developed in accordance with internationally recognized principles on standardization established in the Decision on Principles for the Development of International Standards, Guides and Recommendations issued by the World Trade Organization Technical Barriers to Trade (TBT) Committee.\n2. Referenced Documents (purchase separately) The documents listed below are referenced within the subject standard but are not provided as part of the standard.\nMilitary StandardMIL-I-24244 Specification Insulation Materials with Special Corrosion, Chloride, and Fluoride Requirements Available from DLA Document Services, Building 4/D, 700 Robbins Ave., Philadelphia, PA 19111-5094, http://quicksearch.dla.mil.\nC165 Test Method for Measuring Compressive Properties of Thermal Insulations\nC168 Terminology Relating to Thermal Insulation\nC177 Test Method for Steady-State Heat Flux Measurements and Thermal Transmission Properties by Means of the Guarded-Hot-Plate Apparatus\nC203 Test Methods for Breaking Load and Flexural Properties of Block-Type Thermal Insulation\nC303 Test Method for Dimensions and Density of Preformed Block and BoardType Thermal Insulation\nC390 Practice for Sampling and Acceptance of Thermal Insulation Lots\nC518 Test Method for Steady-State Thermal Transmission Properties by Means of the Heat Flow Meter Apparatus\nC871 Test Methods for Chemical Analysis of Thermal Insulation Materials for Leachable Chloride, Fluoride, Silicate, and Sodium Ions\nD226/D226M Specification for Asphalt-Saturated Organic Felt Used in Roofing and Waterproofing\nD4869/D4869M Specification for Asphalt-Saturated Organic Felt Underlayment Used in Steep Slope Roofing\nISO StandardISO 3951 Sampling Procedure and Charts for Inspection by Variables for Percent Nonconforming Available from American National Standards Institute (ANSI), 25 W. 43rd St., 4th Floor, New York, NY 10036, http://www.ansi.org.\nOther StandardNRC 1.36 Nonmetallic Thermal Insulation for Austenitic Stainless Steel Available from Director of Regulatory Standards, US Atomic Energy Commission, Washington, DC 20545.\nICS Number Code 91.100.60 (Thermal and sound insulating materials)\nUNSPSC Code 30141500(Thermal insulation)\n|Link to Active (This link will always route to the current Active version of the standard.)|\nASTM C240-21, Standard Test Methods for Testing Cellular Glass Insulation Block, ASTM International, West Conshohocken, PA, 2021, www.astm.orgBack to Top", "domain": "chemistry", "round": 3} +{"url": "http://db.yeastgenome.org/reference/8776904/overview", "date": "2014-07-12T00:23:22Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2014-23/segments/1404776430044.46/warc/CC-MAIN-20140707234030-00024-ip-10-180-212-248.ec2.internal.warc.gz", "language_score": 0.9089442491531372, "token_count": 523, "dump": "CC-MAIN-2014-23", "global_id": "webtext-fineweb__CC-MAIN-2014-23__0__15690829", "lang": "en", "text": "A yeast mutant lacking SHR3, a protein specifically required for correct targeting of plasma membrane amino acid permeases, was used to study the targeting of plant transporters and as a tool to isolate new SHR3-independent amino acid transporters. For this purpose, an shr3 mutant was transformed with an Arabidopsis cDNA library. Thirty-four clones were capable of growth under selective conditions, but none showed homology with SHR3. However, genes encoding eight different amino acid transporters belonging to three different transporter families were isolated. Five of these are members of the general amino acid permease (AAP) gene family, one is a member of the NTR family, encoding an oligopeptide transporter, and two belong to a new class of transporter genes. A functional analysis of the latter two genes revealed that they encode specific proline transporters (ProT) that are distantly related to the AAP gene family. ProT1 was found to be expressed in all organs, but highest levels were found in roots, stems, and flowers. Expression in flowers was highest in the floral stalk phloem that enters the carpels and was downregulated after fertilization, indicating a specific role in supplying the ovules with proline. ProT2 transcripts were found ubiquitously throughout the plant, but expression was strongly induced under water or salt stress, implying that ProT2 plays an important role in nitrogen distribution during water stress, unlike members of the AAP gene family whose expression was repressed under the same conditions. These results corroborate the general finding that under water stress, amino acid export is impaired whereas proline export is increased.\n|Evidence ID||Analyze ID||Interactor||Interactor Systematic Name||Interactor||Interactor Systematic Name||Type||Assay||Annotation||Action||Modification||Phenotype||Source||Reference||Note|\n|Evidence ID||Analyze ID||Gene||Gene Systematic Name||Gene Ontology Term||Gene Ontology Term ID||Qualifier||Aspect||Method||Evidence||Source||Assigned On||Annotation Extension||Reference|\n|Evidence ID||Analyze ID||Gene||Gene Systematic Name||Phenotype||Experiment Type||Experiment Type Category||Mutant Information||Strain Background||Chemical||Details||Reference|\n|Evidence ID||Analyze ID||Regulator||Regulator Systematic Name||Target||Target Systematic Name||Experiment||Assay||Construct||Conditions||Strain Background||Reference|", "domain": "chemistry", "round": 3} +{"url": "http://www.abovetopsecret.com/forum/thread1062751/pg1", "date": "2020-10-28T08:45:18Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-45/segments/1603107897022.61/warc/CC-MAIN-20201028073614-20201028103614-00271.warc.gz", "language_score": 0.9353283047676086, "token_count": 350, "dump": "CC-MAIN-2020-45", "global_id": "webtext-fineweb__CC-MAIN-2020-45__0__199843819", "lang": "en", "text": "It looks like you're using an Ad Blocker.\nPlease white-list or disable AboveTopSecret.com in your ad-blocking tool.\nSome features of ATS will be disabled while you continue to use an ad-blocker.\nThe ability to date whatever you like, wherever you like, is the archaeologist’s dream. And it looks like a new carbon-dating technique is about to help make that dream come true.\nIt seems that DigVentures weren’t the only ones promoting groundbreaking innovation last week. A new radio carbon dating technique looks set to join Digital Dig Team as one of the biggest tech innovations set to revolutionise field archaeology this year.\nDeveloped by the University of Liverpool, the new technique uses a Quadrupole Mass Spectrometer, which will reduce the time it takes to get carbon-dating results from a number of weeks to just a couple of days. Even better than that, it can be used on site without needing to send samples away.\nCarbon dating determines the age of archaeological objects, or how long ago a creature died, by measuring the amount of Carbon -14 remaining inside. The method is based on the theory that every living organism contains a small but constant proportion of this radioactive carbon isotope.\nWhen the organism dies the C-14 is no longer replaced and that which remains decays at a constant rate. The time it takes for one half of a radioactive isotope to decay is known as its ‘half-life. By knowing the half-life of C-14 and estimating how many C-14 atoms the organism contained before it died, we can calculate the age of an object or creature at time of death.", "domain": "chemistry", "round": 3} +{"url": "https://iris.univpm.it/handle/11566/32593", "date": "2023-10-01T09:48:53Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233510810.46/warc/CC-MAIN-20231001073649-20231001103649-00267.warc.gz", "language_score": 0.8652060627937317, "token_count": 403, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__284467734", "lang": "en", "text": "The morpho-functional and energy condition of NCTC 2544 cells exposed for 1 hr to a high concentration of H2O2 (500 microM) was studied at 4 and 24 hr to investigate the short- and medium-term biomolecular mechanisms affecting energetic mitochondrial capability. Morphometric data obtained from ultrastructural investigations clearly showed significant modifications of the different mitochondrial parameters--numerical density (Nv), volume density (Vv) and Vv/Nv ratio, in interkinetic, apoptotic and mitotic cells after H2O2 exposure (from 4 to 24 hr). These results were confirmed by the detection at 24 hr of mitochondrial cytochrome c release in the cytosol, indicating impairment in mitochondrial membrane permeability. Data supporting these observations were obtained from the MTT test which showed reduced cell viability in H2O2 treated cultures at 4 hr and an even greater decrement at 24 hr. In conclusion our data imply that significant cause-effect relationships exist between the toxicity of reactive oxygen species (i.e. 500 microM H2O2) and morpho-structural mitochondrial damage in interkinetic, apoptotic and mitotic cells, respectively. They support previous results present both in the literature and also in one of our earlier papers which show that early nuclear DNA damage could initiate mitochondrial or intrinsic apoptotic pathway after H2O2 exposure.\nIn Vitro H2O2 Stress And Patterns Of Mitochondrial Damage In The Nctc 2544 Continuous Cell Line / Pugnaloni, Armanda; Giantomassi, Federica; Armeni, Tatiana; M., Serresi; Principato, Giovanni; Fazioli, Francesca; G., Biagini. - In: CELLULAR AND MOLECULAR BIOLOGY. - ISSN 0145-5680. - ELETTRONICO. - 50 Onlin Pub.:(2004), pp. 517-526.", "domain": "chemistry", "round": 3} +{"url": "https://www.btf-thyroid.org/btf-research-award-2015", "date": "2022-12-05T12:33:33Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-49/segments/1669446711016.32/warc/CC-MAIN-20221205100449-20221205130449-00543.warc.gz", "language_score": 0.9308540225028992, "token_count": 495, "dump": "CC-MAIN-2022-49", "global_id": "webtext-fineweb__CC-MAIN-2022-49__0__182419789", "lang": "en", "text": "Research Research awards BTF Research Award 2015 Diagnosis and management of RTHα – a disorder characterised by tissue-specific hypothyroidism associated with near-normal thyroid function tests. Dr Carla Moran, Consultant Endocrinologist, Addenbrooke's Hospital, Cambridge Introduction Resistance to Thyroid Hormone (RTHα) is a newly-recognised genetic condition with resistance to hormone action in particular tissues (e.g. skeletal muscle, heart, brain, bone), but near-normal circulating thyroid hormones. As such, it represents a disorder that enables the tissue- specific effects of hypothyroidism to be studied. So far, 29 cases have been described in the worldwide published literature and we have identified a further five individuals with the condition. Final Report The current challenges in RTHα include: making a diagnosis, since the changes in thyroid biochemistry are very subtle; and assessing whether treatment with thyroxine is overcoming hormone resistance in some tissues without causing toxicity in other tissues that retain hormone sensitivity. Identification of substances in the blood that could predict patients likely to have RTHα or that could accurately guide therapy would be very helpful in clinical practice. In order to try to address this need, I collaborated with a company called Metabolon to measure approximately 1000 circulating small molecules in blood samples from 15 patients with RTHα and compared the results with healthy individuals. Results from this analysis identified 14 substances (“metabolites”) that can discriminate RTHα patients from healthy individuals with a very high degree of accuracy (93%). If these findings are validated by further research, it may be possible to identify a circulating metabolite profile that could be used to diagnose RTHα in the future. My results have also identified numerous physiological pathways that are perturbed in RTHα and delineated how these changes are affected by thyroxine treatment. Some pathways are known to be regulated by thyroid hormone, but others are novel. If thyroxine therapy in RTHα patients reverses the changes in these pathways, restoring levels of specific metabolites comparable to those of healthy individuals, these substances may be useful markers to guide thyroxine therapy. In summary, my studies may identify a profile of specific metabolites that could be used to diagnose RTHα Following thyroxine therapy in this disorder, metabolite levels may also indicate reversal of hormone resistance in specific tissues with avoidance of toxicity in other, hormone-sensitive, organs.", "domain": "chemistry", "round": 3} +{"url": "https://apostolicwondersmedia.org/what-would-happen-if-oxygen-disappears-for-10-seconds-worldwide/", "date": "2024-04-17T12:55:21Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712296817153.39/warc/CC-MAIN-20240417110701-20240417140701-00325.warc.gz", "language_score": 0.9568390250205994, "token_count": 311, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__131591454", "lang": "en", "text": "Well, first of all, we probably wouldn’t die from suffocation since most of us can hold our breath for 10 seconds. But there would be other more or less serious consequences:\n• The ozone layer would disappear, exposing us to UV rays for 10 seconds.\n• Internal combustion engines would stop functioning.\n• Planes about to take off would crash, while those already in the air would glide.\n• All buildings would turn to dust instantly (oxygen is a major component of concrete).\n• Everyone would experience inner ear damage because the sudden drop in atmospheric pressure by 21% would cause dysfunction in the Eustachian tube.\n• Seas, oceans, lakes, and rivers… All the water would vanish instantly, leaving only hydrogen, which would “float” upwards and never return, being the lightest element.\nSince the Earth’s surface and mantle are composed of 45% oxygen, We would all be in freefall from a great height. But don’t worry; we wouldn’t see or feel anything since we are composed of 60% oxygen. There is oxygen in all our cells, in our DNA… and suddenly, poof! We would turn into a kind of ash. So, it only takes the disappearance of an essential element for 10 seconds (or even less) to annihilate life on Earth.\nThis is why you should be thankful to God and why you should fear God always!", "domain": "chemistry", "round": 3} +{"url": "http://sadipen.de/index.php/epub/carbon-nanotubes", "date": "2022-10-01T04:24:45Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-40/segments/1664030335530.56/warc/CC-MAIN-20221001035148-20221001065148-00362.warc.gz", "language_score": 0.8472010493278503, "token_count": 1228, "dump": "CC-MAIN-2022-40", "global_id": "webtext-fineweb__CC-MAIN-2022-40__0__244899635", "lang": "en", "text": "By BJÖRN HORNBOSTEL, MIRO HALUSKA, JIRKA CECH, URSULA DETTLAFF, SIEGMAR ROTH (auth.), Valentin N. Popov, Philippe Lambin (eds.)\nIt is set 15 years that the carbon nanotubes were chanced on by way of Sumio Iijima in a transmission electron microscope. in view that that point, those lengthy hole cylindrical carbon molecules have printed being outstanding nanostructures for numerous points. they're composed of only one aspect, Carbon, and are simply produced by way of numerous innovations. A nanotube can bend simply yet nonetheless is especially powerful. The nanotubes will be manipulated and contacted to exterior electrodes. Their diameter is within the nanometer diversity, while their size might exceed numerous micrometers, if no longer numerous millimeters. In diameter, the nanotubes behave like molecules with quantized strength degrees, whereas in size, they behave like a crystal with a continuing distribution of momenta. reckoning on its particular atomic constitution, a single-wall nanotube –that is to assert a nanotube composed of only one rolled-up graphene sheet– should be both a steel or a semiconductor. The nanotubes can hold a wide electrical present, also they are solid thermal conductors. it's not impressive, then, that many purposes were proposed for the nanotubes. on the time of writing, certainly one of their such a lot promising functions is their skill to emit electrons whilst subjected to an exterior electrical box. Carbon nanotubes can achieve this in basic vacuum stipulations with an affordable voltage threshold, which lead them to appropriate for cold-cathode devices.\nRead Online or Download Carbon Nanotubes PDF\nSimilar nonfiction_9 books\nSimply because growth within the box of transporters has been amazing, this quantity will concentrate on contemporary advances in our knowing of the constitution, functionality, body structure, and molecular biology of membrane transporters. there'll be an emphasis on transporters as molecular ambitions for drug supply and disposition within the physique.\nThe construction of doubled haploids has develop into an important instrument in complicated plant breeding institutes and advertisement businesses for breeding many crop species. although, the advance of latest, extra effective and less expensive huge scale construction protocols has intended that doubled haploids also are lately being utilized in much less complex breeding programmes.\nThe layout of chemical reactors and their safeguard are as severe to the good fortune of a chemical method because the genuine chemistry happening in the reactor. This publication offers a entire assessment of the sensible facets of multiphase reactor layout and operation with an emphasis on protection and fresh expertise.\nThis revised version of sunlight Astrophysics describes our present knowing of the solar - from its private inside, through the layers of the at once observable surroundings to the sunlight wind, correct out to its farthest extension into interstellar house. It incorporates a finished account of the historical past of sunlight astrophysics, in addition to an outline of the most important tools through the numerous classes.\n- Radiology: The Oral Boards Primer\n- Ciba Foundation Symposium - Adrenergic Mechanisms\n- Global Tea Breeding: Achievements, Challenges and Perspectives\n- Influence of Stress on Cell Growth and Product Formation\nExtra info for Carbon Nanotubes\nB. Nagy, and A. A. Lucas, Scanning tunneling microscope investigation of carbon nanotubes produced by catalytic decomposition of acetylene, Phys. Rev. B 56, 12 490-12498 (1977). 40 26. L. C. Venema, V. Meunier, Ph. Lambin, and C. Dekker, Atomic structure of carbon nanotubes from scanning tunneling microscopy, Phys. Rev. B 61, 2991-2996 (2000). 27. Ph. Kim, T. W. Odom, J. Huang, and Ch. M. Lieber, STM study of single-walled carbon nanotubes, Carbon 38, 1741-1744 (2000). 28. -X. Zha, D. L. Carroll, R.\n17. S. Iijima, Helical microtubules of graphitic carbon, Nature 354, 56–58 (1991). S. Iijima and T. Ichihashi, Single-shell carbon nanotubes of 1-nm diameter, Nature 363, 603–605 (1993). D. S. Bethune, C. H. Kiang, M. S. de Vries, G. Gorman, R. Savoy, J. Vazquez, and R. Beyers, Cobalt-catalysed growth of carbon nanotubes with single-atomic-layer walls, Nature 363, 605–607 (1993). W. Krätschmer, L. O. Lamb, K. Fostiropoulos, and D. R. Huffman, Solid C60: a new form of carbon, Nature 347, 354–358 (1990).\n9. 10. 11. 12. 13. 14. 15. 16. 17. 18. 19. 20. 21. 22. 23. 24. 25. S. Iijima, Helical microtubules of graphitic carbon, Nature 354, 56 -58 (1991). G. E. Scuseria, Negative curvature and hyperfullerenes, Chem. Phys. Lett. 195, 534-536 (1992). L. A. Chernozatonskii, Carbon nanotube connectors and planar jungle gyms, Phys. Lett. A 172, 173 (1992). B. I. Dunlap, Connecting carbon tubules, Phys. Rev. B 46, 1933-1936 (1992). S. Ihara, S. Itoh, and J. Kitakami, Helically coiled cage forms of graphitic carbon, Phys.", "domain": "chemistry", "round": 3} +{"url": "https://products.bronnerbros.com/products/germless%E2%84%A2-8-fl-oz", "date": "2022-06-29T21:30:21Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-27/segments/1656103645173.39/warc/CC-MAIN-20220629211420-20220630001420-00688.warc.gz", "language_score": 0.8043474555015564, "token_count": 310, "dump": "CC-MAIN-2022-27", "global_id": "webtext-fineweb__CC-MAIN-2022-27__0__134440588", "lang": "en", "text": "Germless™ – 8 fl oz.\nEthyl Alcohol 70%………………………… Antiseptic\nFree shipping on case of 12\nHand sanitizer to help reduce bacteria that potentially can cause disease. For use when soap and water are not available.\nFor external use only. Flammable. Keep away from heat or flame\nDo not use\nIn children less than 2 months of age\nOpen skin wounds\nWhen using this product keep out of eyes, ears, and mouth. In case of contact with eyes, rinse eyes thoroughly with water\nStop use and ask a doctor if irritation or rash occurs. These may be signs of a serious condition.\nKeep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away.\n· Place enough product in your palm to cover to cover hands. Rub hands together until dry.\n· Supervise children under 6 years of age when using this product to avoid swallowing.\nStore between 15-30C (59-86F)\nAvoid freezing and excessive heat above 40C (104F)\nInactive ingredients: Water, Glycerin, Panthenol, (Aloe) Barbadensis Leaf Extract, Acrylates/C10-30 Alkyl Acrylate Crosspolymer,\nPolysorbate 80,2-aminoo-2-methyl-1-propanol, Fragrance", "domain": "chemistry", "round": 3} +{"url": "http://www.koreascience.or.kr/article/JAKO201534165173748.page", "date": "2019-06-24T13:26:46Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-26/segments/1560627999539.60/warc/CC-MAIN-20190624130856-20190624152856-00415.warc.gz", "language_score": 0.6791034936904907, "token_count": 970, "dump": "CC-MAIN-2019-26", "global_id": "webtext-fineweb__CC-MAIN-2019-26__0__114165529", "lang": "en", "text": "- Volume 28 Issue 5\nDOI QR Code\nEffects of Microcapsules on Mechanical Properties and Thermal Stability of Microcapsule Embedded Polymeric Resins\n마이크로캡슐이 폴리머 수지의 기계적 특성 및 열안정성에 미치는 영향\n- Received : 2015.09.03\n- Accepted : 2015.10.27\n- Published : 2015.10.31\nThis study investigated the effects of microcapsules on mechanical properties and thermal stability of the composite material containing self-healing microcapsules. To this end, tensile specimens and flexural specimens containing melamine-urea-formaldehyde (M-U-F) shell walled microcapsules with diameters of\nSelf-healing microcapsules;Tensile test;Flexural test;Thermogravimetric analysis test\n- White, S.R., et al., \"Automonic Healing of Polymer Composite Materials\", Nature, Vol. 409, 2001, pp. 794-797. https://doi.org/10.1038/35057232\n- Kessler, M.K., White, S.R., and Sottos, N.R., \"Self-healing Structural Composite Material\", Composites, Part A, Vol. 34, 2003, pp. 743-753. https://doi.org/10.1016/S1359-835X(03)00138-6\n- Yoon, S.H., Park, H.W., and Heo, K.S., \"Evaluation of Bond Performance of Self-Healing Agents using Single Lap Shear Test,\" Journal of the Korean Society for Composite Materials, Vol. 17, No. 4, 2004, pp. 40-46.\n- Toohey, K.S., et al., \"Self-healing Materials with Microvascular Networks\", Nature Materials, Vol. 6, No. 8, 2007, pp. 581-585. https://doi.org/10.1038/nmat1934\n- Yuan, Y.C., et al., \"Study of Factors Related to Performance Improvement of Self Healing Epoxy Based on Dual Encapsulated Healant\", Polymer, Vol. 50, No. 24, 2009, pp. 5771-5781. https://doi.org/10.1016/j.polymer.2009.10.019\n- Murphy, E.B. and Wudl, F., \"The World of Smart Healable Materials,\" Progress in Polymer Science, Vol. 35, No. 1-2, 2010, pp. 223-251. https://doi.org/10.1016/j.progpolymsci.2009.10.006\n- Oh, J.O., Yoon, S.H., and Jang, S.Y., \"Polymerization of Behavior of Self-healing Agents for Damage Repair in Composite Materials,\" Journal of the Korean Society of Propulsion Engineers, Vol. 18, No. 5, 2014, pp. 35-42.\n- ASTM D638, \"Standard Test Method for Tensile Properties of Plastics,\" Annual Book of ASTM, Vol. 08.01, 2003.\n- ASTM D790, \"Standard Test Methods for Flexural Properties of Unreinforced and Reinforced Plastics and Electric Insulating Materials,\" Annual Book of ASTM, Vol. 08.01, 2003.\n- A New Mixing Method of SiC Nanoparticle Reinforced Epoxy Composites with Large Concentration of SiC Nanoparticle vol.29, pp.4, 2016, https://doi.org/10.7234/composres.2016.29.4.223\n- Effects of Solvent-Based Dilution Condition on CNT Dispersion in CNT/Epoxy Composites vol.29, pp.4, 2016, https://doi.org/10.7234/composres.2016.29.4.125\nGrant : 복합재 구조 자가 손상보수 연구\nSupported by : 국방과학연구소", "domain": "chemistry", "round": 3} +{"url": "https://www.thermofisher.com/antibody/product/p23-Antibody-Polyclonal/PA5-28476", "date": "2017-01-19T20:27:41Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-04/segments/1484560280730.27/warc/CC-MAIN-20170116095120-00451-ip-10-171-10-70.ec2.internal.warc.gz", "language_score": 0.7176716327667236, "token_count": 485, "dump": "CC-MAIN-2017-04", "global_id": "webtext-fineweb__CC-MAIN-2017-04__0__193721263", "lang": "en", "text": "Note: You clicked on an external link, which has been disabled in order to keep your shopping session open.\n|Tested species reactivity||Human, Mouse|\n|Host / Isotype||Rabbit / IgG|\n|Immunogen||Recombinant fragment corresponding to a region within amino acids 1 and 160 of Human p23|\n|Purification||Antigen affinity chromatography|\n|Storage buffer||PBS, pH 7, with 1% BSA, 20% glycerol|\n|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|\n|Tested Applications||Dilution *|\n|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|\n|Western Blot (WB)||1:1000-1:10,000|\n* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.\nPA5-28476 targets p23 in IHC (P) and WB applications and shows reactivity with Human and mouse samples.\nThe PA5-28476 immunogen is recombinant fragment corresponding to a region within amino acids 1 and 160 of Human p23.\nMolecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes.\nFor Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.\n23 kD; cPGES; cytosolic prostaglandin E synthase; cytosolic prostaglandin E2 synthase; Hsp90 co-chaperone; p23 cochaperone; progesterone receptor complex p23; prostaglandin E synthase 3; prostaglandin E synthase 3 (cytosolic); sid 3177; TEBP; telomerase binding protein, p23; telomerase-binding protein p23; unactive progesterone receptor; unactive progesterone receptor, 23 kD\n5730442A20Rik; cPGES; P23; Ptges; PTGES3; sid3177; TEBP", "domain": "chemistry", "round": 3} +{"url": "https://www.sigmaaldrich.com/RU/en/tech-docs/paper/648461", "date": "2021-12-01T06:15:12Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-49/segments/1637964359093.97/warc/CC-MAIN-20211201052655-20211201082655-00628.warc.gz", "language_score": 0.9278867840766907, "token_count": 305, "dump": "CC-MAIN-2021-49", "global_id": "webtext-fineweb__CC-MAIN-2021-49__0__196862008", "lang": "en", "text": "The intracellular parasite Trypanosoma cruzi is the aetiological agent of Chagas disease, a public health concern with an increasing incidence rate. This increase is due, among other reasons, to the parasite's drug resistance mechanisms, which require nicotinamide adenine dinucleotide (NAD+). Furthermore, this molecule is involved in metabolic and intracellular signalling processes necessary for the survival of T. cruzi throughout its life cycle. NAD+biosynthesis is performed by de novo and salvage pathways, which converge on the step that is catalysed by the enzyme nicotinamide mononucleotide adenylyltransferase (NMNAT) (enzyme commission number: 220.127.116.11). The identification of the NMNAT of T. cruzi is important for the development of future therapeutic strategies to treat Chagas disease. In this study, a hypothetical open reading frame (ORF) for NMNAT was identified in the genome of T. cruzi.The corresponding putative protein was analysed by simulating structural models. The ORF was amplified from genomic DNA by polymerase chain reaction and was further used for the construction of a corresponding recombinant expression vector. The expressed recombinant protein was partially purified and its activity was evaluated using enzymatic assays. These results comprise the first identification of an NMNAT in T. cruzi using bioinformatics and experimental tools and hence represent the first step to understanding NAD+ metabolism in these parasites.", "domain": "chemistry", "round": 3} +{"url": "https://www.rooterplus.com/blog/the-risks-of-using-a-drain-unblocker", "date": "2024-04-21T23:27:35Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712296818067.32/warc/CC-MAIN-20240421225303-20240422015303-00875.warc.gz", "language_score": 0.94142746925354, "token_count": 453, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__82926168", "lang": "en", "text": "Sink, tub and shower clogs are a nuisance. Let's be honest: If you have a clogged drain, your first inclination is to reach for a drain unblocker. And why not? Advertisers herald the fast-acting, neat and tidy work of drain cleaners. What you may not know about drain unblockers, and what should cause you to carefully consider a better option, is that they're dangerous to your Alpharetta plumbing and septic systems.\nMost drain cleaners contain a harmful substance called sodium hydroxide, a soda component that's highly caustic. As a result, they're corrosive to plumbing pipes and can cause significant damage if they come into contact with your body.\nHazardous to your health\nDrain cleaners are not only harmful to your plumbing and septic systems, but they are also hazardous to humans if ingested, or if they come into contact with skin or eyes. If you store drain cleaners in your home, make sure they are not accessible to children. Store them away on a high shelf or in a locked cabinet. If someone in your household is exposed to a drain cleaner, call the National Poison Control Center at 1-800-222-1222 or 911.\nThe fumes from a drain unblocker alone are hazardous. Opening a can of drain cleaner without sufficient ventilation and inhaling the fumes could lead to respiratory tract damage, compromise lung tissues and, in the worst cases, cause pneumonia.\nHazardous to your plumbing\nPlumbing pipes are also prone to damage from these caustic cleaners. Here's what happens: The chemical reaction in the cleaners generates heat, which helps clear out the debris in the clog but will also eat away at pipes made of metal (often used in older homes) or soften the durability of softer pipes, such as PVC.\nWhy risk your health and plumbing system to the potential dangers of drain cleaners? The next time you need to unclog a drain, contact a professional who will use safe alternatives to hazardous cleaners, such as a powerful snake or hydro jetting. The experts at RooterPLUS! are happy to help Alpharetta residents with these types of issues.\nImage source: Wikimedia Commons", "domain": "chemistry", "round": 3} +{"url": "https://sensohardenberg.nl/2022/06/08/structure-means-a-rocks-chemical-and-you-can/", "date": "2022-08-15T01:34:47Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882572089.53/warc/CC-MAIN-20220814234405-20220815024405-00194.warc.gz", "language_score": 0.9409977197647095, "token_count": 1145, "dump": "CC-MAIN-2022-33", "global_id": "webtext-fineweb__CC-MAIN-2022-33__0__116280539", "lang": "en", "text": "08 jun Structure means a rocks chemical and you can nutrient make-right up\nHaving igneous rock, the fresh new constitution try split up into four communities: felsic, advanced, mafic, and you can ultramafic. These groups refer to different levels of silica, metal, and you can magnesium found in the nutritional elements that define the newest stones. You should see these types of organizations lack clear borders in the wild, but alternatively rest to the an ongoing range with many transformation arrangements and you can brands you to relate to particular quantities of vitamins. For example, granite was a generally-put title but keeps an incredibly particular meaning which has real quantities of nutrients particularly feldspar and you may quartz. Stones labeled as ‘granite when you look at the laymen software should be several other stones, and syenite, tonalite, and you may monzonite. To quit these difficulty, another shape presents a basic style of igneous stone nomenclature emphasizing new four head groups, that is enough to own an introductory beginner.\n- Felsic refers to a predominance of the light-colored (felsic) minerals feldspar and silica in the form of quartz. These light-colored minerals have more silica as a proportion of their overall chemical formula. Minor amounts of dark-colored (mafic) minerals like amphibole and biotite mica may be present as well. Felsic igneous rocks are rich in silica (in the 65-75% range, meaning the rock would be 65-75% weight percent SiO 2 ) and poor in iron and magnesium.\n- Advanced are a composition ranging from felsic and you will mafic. They constantly include around-equal levels of light and you may ebony nutrition, along with white grain out of plagioclase feldspar and ebony nutrition for example amphibole. It is advanced when you look at the silica about 55-60% diversity.\n- Mafic makes reference to loads of ferromagnesian minerals (which have magnesium and you may iron, chemical compounds signs Milligrams and you may Fe) also plagioclase feldspar. It’s mostly made of dark nutritional elements including pyroxene and you can olivine, that are rich in iron and you will magnesium and seemingly terrible for the silica. Mafic rocks is lower in silica, regarding the forty five-50% diversity.\n- Ultramafic is the most mafic stones including mainly olivine and many pyroxene having a lot more magnesium and you may iron and you will even less silica. This type of rocks try uncommon on the surface, however, make up peridotite, new rock of higher mantle. It is bad in the silica, throughout the forty% or less assortment.\nInto the profile over, the top row keeps both plutonic and you may eruptive igneous rocks developed during the a continuous range from felsic into the leftover so you’re able to advanced, mafic, and ultramafic towards the suitable. Rhyolite refers to the eruptive and you may felsic igneous rocks and stone refer to invasive and you can felsic igneous rocks. Andesite and you may diorite in addition relate to extrusive and you will invasive intermediate rocks (with dacite and you will granodiorite deciding on those people stones having constitution ranging from felsic and advanced).\nBasalt and you may gabbro would be the extrusive and you may intrusive names getting mafic igneous rocks, and you can peridotite are ultramafic, with komatiite while the great-grained extrusive comparable. Komatiite try a rare material due to the fact eruptive thing which comes truly throughout the mantle isn’t prominent, even though some instances are in ancient Archean stones . Character barely features evident borders while the category and you may naming out-of stones have a tendency to demand what is apparently sharp line labels on to a continuing range.\nAphanitic/Phaneritic Material Types with Images\nGabbro is a coarse-grained mafic igneous material, made with generally mafic nutritional elements like pyroxene and simply slight plagioclase. Due to the fact mafic lava is more mobile, it is less common than just https://datingranking.net/bbwdesire-review/ basalt. Gabbro was a primary part of the reduced oceanic crust.\nIgneous Stone Regulators\nIgneous stones are common on the geologic record, however, contrary to popular belief, it’s the invasive rocks that will be more prevalent. Extrusive stones, for their quick deposits and you may cup, are less sturdy. Including, he’s, from the definition, confronted with the current weather off erosion quickly. Invasive stones, creating below ground which have larger, stronger crystals, are more inclined to past. For this reason, really landforms and you can stone organizations that are obligated to pay their origin to help you igneous stones is actually invasive regulators. A critical difference to this try energetic volcanoes, which are talked about within the an after part for the volcanism. So it area commonly focus on the well-known igneous government which can be included in many metropolises for the bedrock out of Planet.", "domain": "chemistry", "round": 3} +{"url": "https://research.birmingham.ac.uk/en/publications/metabolic-profiling-reveals-potential-metabolic-markers-associate", "date": "2022-11-28T05:35:30Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-49/segments/1669446710473.38/warc/CC-MAIN-20221128034307-20221128064307-00357.warc.gz", "language_score": 0.9579890370368958, "token_count": 302, "dump": "CC-MAIN-2022-49", "global_id": "webtext-fineweb__CC-MAIN-2022-49__0__69176620", "lang": "en", "text": "Hypoxia inducible factors (HIFs) plays an important role in oxygen compromised environments and therefore in tumour survival. In this research, metabolomics has been applied to study HIFs metabolic function in two cell models: mouse hepatocellular carcinoma and human colon carcinoma, whereby the metabolism has been profiled for a range of oxygen potentials. Wild type cells have been compared to cells deficient in HIF signalling to reveal its effect on cellular metabolism under normal oxygen conditions as well as low oxygen, hypoxic and anoxic environments. Characteristic responses to hypoxia that were conserved across both cell models involved the anti-correlation between 2-hydroxyglutarate, 2-oxoglutarate, fructose, hexadecanoic acid, hypotaurine, pyruvate and octadecenoic acid with 4-hydroxyproline, aspartate, cysteine, glutamine, lysine, malate and pyroglutamate. Further to this, network-based correlation analysis revealed HIF specific pathway responses to each oxygen condition that were also conserved between cell models. From this, 4-hydroxyproline was revealed as a regulating hub in low oxygen survival of WT cells while fructose appeared to be in HIF deficient cells. Pathways surrounding these hubs were built from the direct connections of correlated metabolites that look beyond traditional pathways in order to understand the mechanism of HIF response to low oxygen environments.", "domain": "chemistry", "round": 3} +{"url": "https://pubmed.ncbi.nlm.nih.gov/18573912/", "date": "2021-08-04T03:06:34Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-31/segments/1627046154500.32/warc/CC-MAIN-20210804013942-20210804043942-00315.warc.gz", "language_score": 0.9049013257026672, "token_count": 279, "dump": "CC-MAIN-2021-31", "global_id": "webtext-fineweb__CC-MAIN-2021-31__0__159199346", "lang": "en", "text": "beta-Catenin functions in both cell-cell adhesion and as a transcriptional coactivator in the canonical Wnt pathway. Nuclear accumulation of beta-catenin is the hallmark of active Wnt signaling and is frequently observed in human cancers. Although beta-catenin shuttles in and out of the nucleus, the molecular mechanisms underlying its translocation remain poorly understood. Chibby (Cby) is an evolutionarily conserved molecule that inhibits beta-catenin-mediated transcriptional activation. Here, we identified 14-3-3epsilon and 14-3-3zeta as Cby-binding partners using affinity purification/mass spectrometry. 14-3-3 proteins specifically recognize serine 20 within the 14-3-3-binding motif of Cby when phosphorylated by Akt kinase. Notably, 14-3-3 binding results in sequestration of Cby into the cytoplasm. Moreover, Cby and 14-3-3 form a stable tripartite complex with beta-catenin, causing beta-catenin to partition into the cytoplasm. Our results therefore suggest a novel paradigm through which Cby acts in concert with 14-3-3 proteins to facilitate nuclear export of beta-catenin, thereby antagonizing beta-catenin signaling.", "domain": "chemistry", "round": 3} +{"url": "http://kar.kent.ac.uk/22970/", "date": "2013-06-18T06:45:15Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2013-20/segments/1368707184996/warc/CC-MAIN-20130516122624-00077-ip-10-60-113-184.ec2.internal.warc.gz", "language_score": 0.863055408000946, "token_count": 381, "dump": "CC-MAIN-2013-20", "global_id": "webtext-fineweb__CC-MAIN-2013-20__0__66965834", "lang": "en", "text": "Hawkins, H.C. and Blackburn, E.C and Freedman, R.B. (1991) Comparison of the activities of protein disulfide-isomerase and thioredoxin in catalyzing disulfide isomerization in a protein substrate. Biochemical Journal, 275 . pp. 349-353. ISSN 0264-6021.\n|The full text of this publication is not available from this repository. (Contact us about this Publication)|\n1. The activities of protein disulphide-isomerase (PDI) and thioredoxin in catalysing disulphide bond isomerization in a protein substrate were compared by using the standard assay, namely the re-activation of 'scrambled' RNAase. 2. The specific activity of PDI was 25-fold greater than that of thioredoxin. 3. The greater efficiency of PDI compared with thioredoxin is considered to be due more to the presence of multiple catalytic domains in PDI than to differences in their active-site sequences. 4. Data and procedures were defined for expressing enzyme activity in standard units, i.e. mu-mol of active RNAase generated/min.\n|Subjects:||Q Science > QP Physiology (Living systems)|\n|Divisions:||Faculties > Science Technology and Medical Studies > School of Biosciences|\n|Depositing User:||O.O. Odanye|\n|Date Deposited:||04 Nov 2009 11:11|\n|Last Modified:||30 May 2012 10:53|\n|Resource URI:||http://kar.kent.ac.uk/id/eprint/22970 (The current URI for this page, for reference purposes)|\n- Depositors only (login required):", "domain": "chemistry", "round": 3} +{"url": "http://biosntr.org/node/21", "date": "2019-03-25T19:46:09Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-13/segments/1552912204300.90/warc/CC-MAIN-20190325194225-20190325220225-00003.warc.gz", "language_score": 0.7690299153327942, "token_count": 612, "dump": "CC-MAIN-2019-13", "global_id": "webtext-fineweb__CC-MAIN-2019-13__0__147057738", "lang": "en", "text": "Suvobrata (Suvo) Chakravarty, PhD\nDr. Chakravarty's lab's long-term interest is in understanding how protein-protein interactions (PPIs) on the chromosomes ultimately regulate the expressions of genes. They currently focus on understanding how proteins interact with histones, the key components of chromatin. They utilize a structure-function approach to understand and probe these interaction mechanisms. They are also developing experimental and computations methods for the detection and characterization of PPIs.\nAreas of expertise:\nRecombinant protein biochemistry, biophysical chemistry, structural biology, bioinformatics and computational biology\nChakravarty S*, Essel F, Lin T & Zeigler S (2015) Histone peptide recognition by KDM5B-PHD1, a case study, Biochemistry 54: 5766-5780.\nChakravarty S*, Sheng Z, Iverson B, Moore B (2012). h6-type anion-p in Biomolecular Recognition. FEBS Lett. 586: 4180-6.\nChakravarty S, Lei Zeng & Ming-Ming Zhou (2009). Structure and Site-Specific Recognition of Histone H3 by the PHD Finger of Human Autoimmune Regulator. Structure 17, 670-679.\nChakravarty S, Wang L & Sanchez R (2005). Accuracy of Structure-derived properties in Simple Comparative models of Protein Sctructure. Nucleic Acid Research 33, 244-259.\nChakravarty S, & Sanchez R (2004). Systematic Analysis of Added-value in Simple Comparative models of Protein Sctructure. Structure 12, 1461-1470.\nChakravarty S & Varadarajan R (2002). Elucidation of factors responsible for enhanced thermal stability of proteins: a structural genomics based study. Biochemistry 41, 8152-8161.\nChakravarty S, Bhinge A & Varadarajan R (2002). A procedure for detection and quantitation of cavity volumes in proteins: application to measure the strength of the hydrophobic driving force in protein folding. J Biol Chem 277, 31345-53.\nChakravarty S, Mitra N, Queitsch I, Surolia A, Varadarajan R, Dubel S (2000). Protein stabilization through phage display. FEBS Lett. 476, 296-300.\nChakravarty S & Varadarajan R (2000). Elucidation of determinants of protein stability through genome sequence analysis. FEBS Lett. 470, 65-69.\nChakravarty S & Varadarajan R (1999). Residue depth: a novel parameter for the analysis of protein structure and stability. Structure Fold Des. 7, 723-732.\nReturn to Members main page.", "domain": "chemistry", "round": 3} +{"url": "https://www.ansaroo.com/types/water+pollution", "date": "2022-11-29T06:57:45Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-49/segments/1669446710690.85/warc/CC-MAIN-20221129064123-20221129094123-00068.warc.gz", "language_score": 0.952947735786438, "token_count": 423, "dump": "CC-MAIN-2022-49", "global_id": "webtext-fineweb__CC-MAIN-2022-49__0__281326348", "lang": "en", "text": "Chemical pollution definition. The definition of chemical pollution: When chemicals are released into our environment and disrupts the balance of our ecosystems, threatening our health, polluting the air we breathe and contaminating our food. There are many sources of chemical pollution.\nNutrient pollution is the process where too many nutrients, mainly nitrogen and phosphorus, are added to bodies of water and can act like fertilizer, causing excessive growth of algae. Nutrients can run off of land in urban areas where lawn fertilizers are used.\nThe Oil Spill Pollution Act - The Oil Pollution Act is an environmental regulation adopted in 1990 in the U.S. to prevent oil spill pollution. In 1990, the Oil Pollution Act was passed by U.S. Congress and amended the existing Clean Water Act, aiming to require oil storage facilities to prepare \"Facility Response Plans\".\nOcean oxygen depletion water pollution. So far it has become clear that without О 2 there is no life. Dead zones is the term used when we refer to the parts of the oceans which are left with little or no oxygen. In these places, there are no marine animals simply because they cannot survive under such conditions.\nThe most difficult water pollution to see is groundwater pollution, which is the pollution of water sources below Earth's surface. Like surface water, groundwater can be contaminated from a variety of sources, but because it is below ground, it's more difficult to monitor and control.\nSuspended matter is made up of fine particles. Some are present naturally in river water, such as plankton, fine plant debris and minerals, while others stem from human activity (organic and inorganic matter). Suspended matter can make water more turbid, which has a negative impact on river and stream biology.\nTypes of water pollution There are many types of water pollution because water comes from many sources. Here are a few types of water pollution: 1. Nutrients Pollution Some wastewater, fertilizers and sewage contain high levels of nutrients. If they end up in water bodies, they encourage algae and weed growth in the water.", "domain": "chemistry", "round": 3} +{"url": "https://roidit.net/hilma-biocare/ghrp-6-hilma-biocare", "date": "2024-03-04T07:56:07Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707947476432.11/warc/CC-MAIN-20240304065639-20240304095639-00239.warc.gz", "language_score": 0.8996877670288086, "token_count": 394, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__119222938", "lang": "en", "text": "- Brand: Hilma Biocare\n- Sku: 12334551\n- Availability: In Stock\n- Product overview\n- Reviews (0)\nManufacturer: Hilma Biocare\nPackage: 10 mg\nInfo: GHRP-6 (Growth Hormone Releasing Hexapeptide) is a peptide hormone from the growth hormone (GH) class. The purpose of GHRP-6, as with all related peptides, is to increase the amount of natural GH production in the body. GH increases can benefit anabolism, fat loss, recovery, general well-being, and serve anti-aging purposes.\nGHRP-6, and this is true of all GHRP hormones, mimics the production of ghrelin. This mode of action stimulates the ghrelin, GHS-R1a or growth hormone secretagogue receptors. This stimulation acts to increase GH production by stimulating the pituitary gland, specifically the ghrelin receptors located in the pituitary gland.\nHigh ghrelin is also known to stimulate appetite. Alternatively, the hormone promotes fat loss and, more importantly, improves recovery rates. Although ghrelin has been shown to promote recovery, GHRP-6 and elevated GH levels are more likely to have a greater role in correspondingly elevated IGF-1 levels. IGF-1 levels do not increase at a rate comparable to direct application of human growth hormone (HGH) because the pulsatile effect of GHRP-6 is short-lived.\nGHRP-6 is also a glucose-dependent hormone, especially when blood glucose levels are low. High blood glucose levels cause GHRP-6 to become weaker, which means it must be taken during a fasting state to achieve its intended benefits.\nThere are no reviews for this product.\nNo questions about this product, be the first and ask your question.", "domain": "chemistry", "round": 3} +{"url": "http://crompion.com/content.cfm?new=393&id=248", "date": "2019-04-26T10:37:58Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-18/segments/1555578765115.93/warc/CC-MAIN-20190426093516-20190426114636-00010.warc.gz", "language_score": 0.9259030222892761, "token_count": 388, "dump": "CC-MAIN-2019-18", "global_id": "webtext-fineweb__CC-MAIN-2019-18__0__217531674", "lang": "en", "text": "Proven Benefits of Cromgard\nIn addition to grade-specific features, all Cromgard® grades offer the following additional benefits:\nPrice Stable Alternative to High Nickel Stainless Steels\nCromgard® is a “cost stable” stainless steel, which means it is not subject to erratic price fluctuations because it does not depend upon expensive alloying elements like nickel and molybdenum. It has therefore maintained a consistently lower cost advantage compared to other corrosion-resisting materials. Cromgard® also helps to reduce costs by eliminating the need for protective treatments and material corrosion allowances.\nExcellent Welding & Forming Properties\nCromgard® provides good weldability and formability, making it capable of fabrication by conventional techniques. The substantially austenitic microstructure at elevated temperatures also restricts grain growth during welding, which leads to a tough duplex martensitic/ferritic heat affected zone.\nIn service, Cromgard® generates savings in maintenance, improved productivity and longer service life. In a wide variety of applications, it has been extremely successful in displacing coated carbon steel, Corten and aluminum. In every case, Cromgard® demonstrates a realistic performance or economical advantage, often both.\nCromgard® has several notable characteristics at elevated temperatures: reasonable mechanical properties; good scaling and oxidation resistance, including resistance to sulphur-bearing atmospheres; negligible embrittlement after extended exposure to temperatures between 842°F and 1022°F; and resistance to many hot gases and fumes generated in industrial processes.\nOptimized Life-cycle Cost\nThe Cromgard® Family of Stainless Steels was created to impact the total life cycle cost of equipment. While these metals are certainly cost effective on the front end, their benefit is even more impressive on the back end helping to reduce future cost such as maintenance, raw materials, labor and downtime (or removal of the equipment from service).", "domain": "chemistry", "round": 3} +{"url": "https://ui.adsabs.harvard.edu/abs/2010Natur.464..431H", "date": "2022-08-14T02:15:53Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571989.67/warc/CC-MAIN-20220813232744-20220814022744-00427.warc.gz", "language_score": 0.8786240816116333, "token_count": 332, "dump": "CC-MAIN-2022-33", "global_id": "webtext-fineweb__CC-MAIN-2022-33__0__162765165", "lang": "en", "text": "Activating mutations in KRAS and BRAF are found in more than 30% of all human tumours and 40% of melanoma, respectively, thus targeting this pathway could have broad therapeutic effects. Small molecule ATP-competitive RAF kinase inhibitors have potent antitumour effects on mutant BRAF(V600E) tumours but, in contrast to mitogen-activated protein kinase kinase (MEK) inhibitors, are not potent against RAS mutant tumour models, despite RAF functioning as a key effector downstream of RAS and upstream of MEK. Here we show that ATP-competitive RAF inhibitors have two opposing mechanisms of action depending on the cellular context. In BRAF(V600E) tumours, RAF inhibitors effectively block the mitogen-activated protein kinase (MAPK) signalling pathway and decrease tumour growth. Notably, in KRAS mutant and RAS/RAF wild-type tumours, RAF inhibitors activate the RAF-MEK-ERK pathway in a RAS-dependent manner, thus enhancing tumour growth in some xenograft models. Inhibitor binding activates wild-type RAF isoforms by inducing dimerization, membrane localization and interaction with RAS-GTP. These events occur independently of kinase inhibition and are, instead, linked to direct conformational effects of inhibitors on the RAF kinase domain. On the basis of these findings, we demonstrate that ATP-competitive kinase inhibitors can have opposing functions as inhibitors or activators of signalling pathways, depending on the cellular context. Furthermore, this work provides new insights into the therapeutic use of ATP-competitive RAF inhibitors.", "domain": "chemistry", "round": 3} +{"url": "http://www.nutritional-feedadditives.com/sale-7956215-2000u-g-enzyme-feed-additive-alpha-galactosidase-powder-szym-ags2fe-for-animal-nutrition.html", "date": "2021-01-18T23:05:58Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-04/segments/1610703517159.7/warc/CC-MAIN-20210118220236-20210119010236-00787.warc.gz", "language_score": 0.7709059119224548, "token_count": 647, "dump": "CC-MAIN-2021-04", "global_id": "webtext-fineweb__CC-MAIN-2021-04__0__14102290", "lang": "en", "text": "Payment & Shipping Terms:\n|Product Name:||Alpha-Galactosidase Szym-AGS2FE||Type:||Alpha-Galactosidase|\npoultry feed enzymes,\nfeed enzymes in poultry nutrition\n2000u/g Enzyme Feed Additive Alpha Galactosidase Powder Szym-AGS2FE for Animal Nutrition\nSINOzym-AGS2FE is a powder-type alpha-galactosidase preparation made from excellent strain through fermentation and extraction technique with spray drying.\nCAS No.: 9025-35-8\nEINECS No.: 22.214.171.124\n|Odor||:Slight fermentation odor|\n|Loss on drying||:≤10%|\n|Particle size||:More than 95% pass through standard sieve of 80 mesh|\nOptimum pH: 5.5;\npH range: Relative activity remains on above 80% at pH4.5-7;\nOptimum temperature: 55 degree centigrade;\nTemperature range: Relative activity remains on above 60% at T45-60℃;\nAcid resistance: Activity is above 80% after acidic treatment for 4 hours at pH3.0-7.0;\nHeat resistance: Activity is above 80% after heat-treatment for 10 min at T 30-60℃.\n1 unit of α-galactosidase activity (U) is defined as the amount of enzyme which liberates 1 micromole of paranitrophenol per minute from 10 mmol/L of paranitrophenol-α-D-galactopyranose solution at pH 5.5 and 37 degrees centigrade.\nApplication Field & Efficacy:\n--Used as poultry feed supplement enzyme to promote healthy & growth, promote nutrition;\n--Degrade resistance factor as α-galactoside in feed and reduce chime viscosity in intestine;\n--Decrease the anti-nutritional factor in feed and promote the absorption of nutrients;\n--Degrade the flatulence factor in soybean and decrease incidence of diarrhea;\n--Increase animal’s immunity and reduce the prevalence of disease.\nPackaging & Delivery:\n20/25kg/bag or drum; Or package as per requirement.\n1 x 20'FCL can contain 10 -13 tons if in bag type package.\nThis product is an active biological preparation. It should be stored and transported in a cool, dry and ventilated place avoiding sunlight.\nUnder favorable storage condition of below 25°C, the shelf life is 12 months.\nNotice: Tighten the pocket mouth after each usage to avoid pollution or damp.\nEnzyme preparations belong to protein, which may induce sensitization and cause allergic type reactions in sensitized individuals. Prolonged contact may cause minor irritation for skin, eyes or mucous membrane of nose, so any direct contiguity with human body should be avoided. If irritation or allergic response for skin or eyes develops, consult a doctor.\nContact Person: Alfonso", "domain": "chemistry", "round": 3} +{"url": "https://www.coursehero.com/file/6821982/Chem210-1-F08-Ex1-p01a/", "date": "2018-05-21T11:37:10Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-22/segments/1526794864063.9/warc/CC-MAIN-20180521102758-20180521122758-00124.warc.gz", "language_score": 0.8319977521896362, "token_count": 299, "dump": "CC-MAIN-2018-22", "global_id": "webtext-fineweb__CC-MAIN-2018-22__0__182796298", "lang": "en", "text": "Unformatted text preview: [(1-ethyl-1-methylpropyl)cyclopentane] cis-1,1,2,3-tetramethylcyclopropane 3-ethyl-7-methylnonane amine amide aromatic The amine nitrogen is more basic (circled above); the major factor: the e l e c t r o n d e n s i t y o f t h e a m i d e n i t r o g e n i s l o w e r a t n i t r o g e n b e c a u s e o f d e l o c a l i z a t i o n t o t h e c a r b o n y l o x y g e n and (to a lesser extent) because of delocalization into the adjacent benzene ring. To a lesser extent, inductive bond polarization also contributes: the alkyl group substituents on the amine nitrogen donate electron density (increasing basicity); the carbonyl oxygen withdraws electron density (by bond polarization) to further decrease basicity there. Finally, anyone may be asked to change seats at any time during the exam - if asked to do so, please move to the new seat location as expeditiously as possible....\nView Full Document\n- Fall '08\n- Trigraph, Functional group, Amide, Lidocaine, Local anesthetic", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/ph3-antibody-ab264212.html", "date": "2020-06-05T11:23:02Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-24/segments/1590348500712.83/warc/CC-MAIN-20200605111910-20200605141910-00363.warc.gz", "language_score": 0.7461487650871277, "token_count": 545, "dump": "CC-MAIN-2020-24", "global_id": "webtext-fineweb__CC-MAIN-2020-24__0__125945356", "lang": "en", "text": "Product nameAnti-PH3 antibody\nSee all PH3 primary antibodies\nDescriptionRabbit polyclonal to PH3\nTested applicationsSuitable for: IPmore details\nUnsuitable for: WB\nSpecies reactivityReacts with: Human\nSynthetic peptide within Human PH3 aa 933-983. The exact sequence is proprietary.\nDatabase link: Q8NDX5\n- IP: HeLa whole cell lysate.\nStorage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C. Avoid freeze / thaw cycle.\nStorage bufferPreservative: 0.09% Sodium azide\nConstituent: Tris citrate/phosphate\npH 7 to 8\nConcentration information loading...\nPurityImmunogen affinity purified\nOur Abpromise guarantee covers the use of ab264212 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\n|IP||Use at 2-5 µg/mg of lysate.|\nFunctionComponent of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.\nSequence similaritiesContains 1 FCS-type zinc finger.\nContains 1 SAM (sterile alpha motif) domain.\nmodificationsPhosphorylated upon DNA damage, probably by ATM or ATR.\n- Information by UniProt\n- Early development regulator 3 antibody\n- Early development regulatory protein 3 antibody\n- EDR3 antibody\nPH3 was immunoprecipitated from 1mg of HeLa (Human epithelial cell line from cervix adenocarcinoma) whole cell lysate with ab264212 at 3 µg/mg lysate. Western blot was performed from the immunoprecipitate using a different antibody.\nLane 1: ab264212 IP in HeLa whole cell lysate.\nLane 2: Control IgG.\nExposure time: 3 mins.\nCells prepared using NETN lysis buffer.\nab264212 has not yet been referenced specifically in any publications.", "domain": "chemistry", "round": 3} +{"url": "https://biography.omicsonline.org/serbia-and-montenegro/university-of-kragujevac/milutin-milutinovi-422194", "date": "2023-09-22T06:08:38Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233506329.15/warc/CC-MAIN-20230922034112-20230922064112-00071.warc.gz", "language_score": 0.752882719039917, "token_count": 531, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__71660549", "lang": "en", "text": "Institute of Biology and Ecology\nUniversity of Kragujevac\nSerbia and Montenegro\nDr Milena Milutinović successfully works in the Laboratory for Experimental Animal Physiology and Laboratory for Cellular and Molecular Biology, Institute of Biology and Ecology, Faculty of Medicine in Kragujevac, where she has mastered modern techniques and methods of physiological-biochemical, hematological and molecular- biological analyzes that are present in these laboratories. During her scientific research she gained basic theoretical knowledge, ovalned experimental research methods in the field of physiology, cell and molecular biology. Most of the methods of research within her dissertation have been introduced into regular laboratory practice.\nPhysiology of animals and humans, molecular biology\nĆurčić M. , Stanković M, Radojević I, Stefanović O, Čomić Lj, Topuzović M, Đačić D, Marković S. Biological effects, total phenolic content and flavonoid concentrations of fragrant yellow onion (Allium flavum L.). Medicinal Chemistry, 2012, 8 (1): 46-51. ISSN: 1573-4064. IF2010: 1.603. M23 DOI: 10.2174 / 157340612799278441\nĆurčić M. , Stanković M, Cvetković D, Topuzović M, Marković S. Ligustrum vulgare L .: In vitro free radical scavenging activity and pro - oxidant properties in human colon cancer cell lines. Digest Journal of Nanomaterials and Biostructures, 2014, 9 (4), 1689-1697. M23 ISSN: 1842-3582. IF2013: 1.123.\nMilutinović M. , Stanković M, Cvetković D, Maksimović V, Šmit B, Pavlović R, Marković S. The molecular mechanisms of apoptosis induced by Allium flavum L. and synergistic effects with new-synthesized Pd (II) complex on colon cancer cells. Journal of Food Biochemistry, 2015, 39: 238-250. M23 ISSN: 0145-8884. IF2013: 0.853 DOI: 10.1111 / jfbc.12123", "domain": "chemistry", "round": 3} +{"url": "http://oai.dtic.mil/oai/oai?verb=getRecord&metadataPrefix=html&identifier=ADA332940", "date": "2018-02-25T14:18:09Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-09/segments/1518891816462.95/warc/CC-MAIN-20180225130337-20180225150337-00622.warc.gz", "language_score": 0.889272153377533, "token_count": 519, "dump": "CC-MAIN-2018-09", "global_id": "webtext-fineweb__CC-MAIN-2018-09__0__6436571", "lang": "en", "text": "Accession Number : ADA332940\nTitle : Pilot Demonstration of Nitrate-Based Bioremediation of Fuel-Contaminated-Aquifer at Eglin AFB, Florida: Site Characterization, Design, and Performance Evaluation\nDescriptive Note : Final rept., Oct 92-Sep 96\nCorporate Author : ROBERT S KERR ENVIRONMENTAL RESEARCH LAB ADA OK\nPersonal Author(s) : Hutchins, S. R. ; Miller, D. E. ; Thomas, J. M. ; Ward, C. H. ; Wiesner, M. R.\nPDF Url : ADA332940\nReport Date : APR 1997\nPagination or Media Count : 240\nAbstract : The objective of this research was to compare the extent of bioremediation of a fuel-contaminated aquifer using aerobic recharge with and without nitrate addition. This research was undertaken to provide a direct comparison through the operation of a pilot project at a JP-4 jet fuel-contaminated aquifer at Eglin AFB, FL. Nitrate can serve as an electron acceptor and results in anaerobic biodegradation of organic compounds via the processes of nitrate reduction and denitrification. Because nitrate is less expensive and more soluble than oxygen, it may be more economical to remediate fuel-contaminated aquifers using nitrate rather than oxygen. The pilot project treatment system consisted of two adjacent 100-foot x 100-foot cells that received nitrate-amended and unamended recharge, respectively, through sprinkler application. Performance was continuously monitored through the use of both conventional and cluster wells located within and outside of the treatment cells. Performance evaluation, consisting of extensive chemical, microbial, and toxicological analyses of aquifer sediments and groundwater, were conducted after 4 and 12 months of operation to provide a thorough evaluation of the extent of nitrate-based bioremediation. Results showed recharge application had a positive effect on both cells, resulting in decreased contaminant loads, increased nutrient distribution, increased microbial populations, and decreased sediment toxicity.\nDescriptors : *AQUIFERS, *ENVIRONMENTAL PROTECTION, *NITRATES, PILOTS, FUELS, CONTAMINATION, BIODEGRADATION, POLLUTION, AEROBIC PROCESSES, FLORIDA.\nSubject Categories : Water Pollution and Control\nDistribution Statement : APPROVED FOR PUBLIC RELEASE", "domain": "chemistry", "round": 3} +{"url": "https://athenaeum.libs.uga.edu/handle/10724/27664", "date": "2021-09-25T15:29:01Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-39/segments/1631780057687.51/warc/CC-MAIN-20210925142524-20210925172524-00199.warc.gz", "language_score": 0.9208672046661377, "token_count": 630, "dump": "CC-MAIN-2021-39", "global_id": "webtext-fineweb__CC-MAIN-2021-39__0__188409481", "lang": "en", "text": "Functional role for the mannose phosphorylation on two non-lysosomal proteins\nBarnes, Jarrod Wesley\nMetadataShow full item record\nThe mannose-6-phosphate (Man-6-P) targeting pathway represents one of the best-studied examples of the ability of carbohydrates to carry information. Acid hydrolases that are modified with Man-6-P residues on their N-glycans are targeted to the lysosomes by Man-6-P receptors. In addition to these enzymes, many non-lysosomal proteins have been shown to bear phosphomannosyl residues. The functional relevance of the mannose phosphorylation on non-lysosomal proteins, however, remains poorly defined. More importantly, the pathogenic consequences associated with the impaired mannose phosphorylation of these proteins in the lysosomal storage disease mucolipidosis II (ML-II) have not been determined. In the present work, the extent and functional role of mannose phosphorylation on two non-lysosomal proteins, leukemia inhibitory factor (LIF) and transforming growth factor beta 1 (TGF-β1), was investigated using biochemical approaches. Secreted LIF was demonstrated to be highly Man-6-P modified by cation-independent Man-6-P receptor (CI-MPR) affinity chromatography. Removal of specific N-glycan sites on LIF resulted in decreased mannose phosphorylation and a corresponding increase in its steady-state extracellular levels. Subsequent experiments showed that LIF mannose phosphorylation controls its extracellular levels by means of Man-6-P-dependent internalization and direct intracellular targeting of this molecule to the lysosomes. Loss of mannose phosphorylation in ML-II likely leads to excessive extracellular LIF, providing a potential mechanism for the bone phenotypes associated with this disease. Contrary to our findings with LIF, latent TGF-β1 was demonstrated to be poorly mannose phosphorylated and its activation was not altered by free Man-6-P addition when latent forms were present. These results indicate that latent TGF-β1 activation is not mediated by direct Man-6-P modification of its latency-associated peptide. Although loss of mannose phosphorylation in ML-II was not predicted to alter TGF-β1 activation, decreased signaling of this growth factor, and a corresponding reduction in wound closure, was surprisingly noted in human and feline ML-II fibroblasts. Diminished activation of latent TGF-β1 was further associated with a striking decrease in its detergent solubility, possibly due to upregulation of tissue transglutaminase. Collectively, these results indicate that the loss of Man-6-P biosynthesis on non-lysosomal proteins may directly (LIF) or indirectly (TGF-β1) affect their function and contribute to the pathogenesis of ML-II.", "domain": "chemistry", "round": 3} +{"url": "https://www.cellsignal.com/product/productDetail.jsp?productId=12645", "date": "2018-06-19T12:44:29Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-26/segments/1529267862929.10/warc/CC-MAIN-20180619115101-20180619135101-00466.warc.gz", "language_score": 0.9072225689888, "token_count": 544, "dump": "CC-MAIN-2018-26", "global_id": "webtext-fineweb__CC-MAIN-2018-26__0__133850449", "lang": "en", "text": "The ALK Antibody Sampler Kit provides an economical means of detecting total ALK as well as ALK phosphorylated at various residues. The kit includes enough antibody to perform four western blot experiments with each primary antibody.\nALK (C26G7) Rabbit mAb detects endogenous levels of total ALK protein. This antibody does not cross-react with other family members. Each activation state antibody recognizes only its specific target. Slight cross-reactivity with over expressed receptor tyrosine kinases may occur.\nMonoclonal antibodies are produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Tyr1078, Tyr1096, Tyr1278, Tyr1282/1283, or Tyr1586 of human ALK protein, or a recombinant fusion protein surrounding amino acid 1475 of human ALK protein. Polyclonal antibodies are produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Tyr1278/1282/1283 or Tyr1604 of human ALK protein. Antibodies are purified by protein A and peptide affinity chromatography.\nAnaplastic lymphoma kinase (ALK) is a tyrosine kinase receptor for pleiotrophin (PTN), a growth factor involved in embryonic brain development (1-3). In ALK-expressing cells, PTN induces phosphorylation of both ALK and the downstream effectors IRS-1, Shc, PLCγ, and PI3 kinase (1). ALK was originally discovered as a nucleophosmin (NPM)-ALK fusion protein produced by a translocation (4). Investigators have found that the NPM-ALK fusion protein is a constitutively active, oncogenic tyrosine kinase associated with anaplastic lymphoma (4). Research literature suggests that activation of PLCγ by NPM-ALK may be a crucial step for its mitogenic activity and involved in the pathogenesis of anaplastic lymphomas (5).\nA distinct ALK oncogenic fusion protein involving ALK and echinoderm microtubule-associated protein like 4 (EML4) has been described in the research literature from a non-small cell lung cancer (NSCLC) cell line, with corresponding fusion transcripts present in some cases of lung adenocarcinoma. The short, amino-terminal region of the microtubule-associated protein EML4 is fused to the kinase domain of ALK (6-8).\nCell Signaling Technology is a trademark of Cell Signaling Technology, Inc.\nExplore pathways related to this product.", "domain": "chemistry", "round": 3} +{"url": "http://www.abcam.cn/recombinant-cow-ip10-protein-ab87463.html", "date": "2017-07-28T11:07:48Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-30/segments/1500549448198.69/warc/CC-MAIN-20170728103510-20170728123510-00300.warc.gz", "language_score": 0.6786707043647766, "token_count": 450, "dump": "CC-MAIN-2017-30", "global_id": "webtext-fineweb__CC-MAIN-2017-30__0__41657183", "lang": "en", "text": "- 产品名称Recombinant牛IP10 protein\n参阅全部 IP10 蛋白酶\n- 蛋白长度Full length protein\n- 序列VPLSRNTRCS CIEISNGSVN PRSLEKLEVI PASQSCPRVE IIATMKKNGE KRCLNPESKT IKNLLKAINK QRTKRSPRTR KEA\n- 氨基酸20 to 102\nOur Abpromise guarantee covers the use of\nin the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\nConcentration information loading...\nShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.\nConstituents: 10% Trehalose, 1.0X PBS\n- 复溶Reconstitute with sterile phosphate-buffered saline containing at least 0.1% carrier protein.\n- Interferon gamma induced factor MOB1, mouse, homolog of\n- Interferon gamma induced protein 10\n- 10 kDa interferon gamma induced protein\n- 功能Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3.\n- 序列相似性Belongs to the intercrine alpha (chemokine CxC) family.\n- 翻译后修饰CXCL10(1-73) is produced by proteolytic cleavage after secretion from keratinocytes.\nInformation by UniProt\nRecombinant Cow IP10 protein (ab87463)参考文献\nhas not yet been referenced specifically in any publications.\nPlease note: All products are \"FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE\"", "domain": "chemistry", "round": 3} +{"url": "http://www.informaticsjournals.com/index.php/jsst/article/view/16264", "date": "2021-04-18T23:07:52Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-17/segments/1618038862159.64/warc/CC-MAIN-20210418224306-20210419014306-00577.warc.gz", "language_score": 0.7062417268753052, "token_count": 843, "dump": "CC-MAIN-2021-17", "global_id": "webtext-fineweb__CC-MAIN-2021-17__0__12987127", "lang": "en", "text": "Microstructural and Mechanical Properties of Cu-based Alloy Manufactured by Self-Propagating High-Temperature Synthesis Method\nMicrostructure and properties of Cu1-xZn1-yAl1-z ranging through (0.29 =4; V = Ctriple boundC or CH=CH; R = fluorescent group.\n[origin: EP1046648A1] 3'-Deoxyribonucleotide derivatives represented by the following general formula ÄIÜ: Q-V-(CH2)n-NR-R wherein Q represents a 3'-deoxyribonucleotide residue; n is an integer of 4 or more; V represents -C IDENTICAL C- or -CH=CH-; and R represents a fluorescent group. Because of having been improved in the uptake efficiency by RNA polymerases, these derivatives are useful as terminators in DNA base sequencing methods with the use of RNA polymerases.\nIPC 1-7 (main, further and additional classification)\nIPC 8 full level (invention and additional information)\nCPC (invention and additional information)\nC07H 19/04 (2013.01)\nCitation (search report)\nDesignated contracting state (EPC)\nCH DE DK ES FR GB IT LI NL SE", "domain": "chemistry", "round": 3} +{"url": "https://coloradohealthresearchcouncil.com/pros-cons-flower-and-concentrates/", "date": "2024-04-15T22:18:22Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712296817033.56/warc/CC-MAIN-20240415205332-20240415235332-00894.warc.gz", "language_score": 0.8997318744659424, "token_count": 673, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__17767861", "lang": "en", "text": "Here are some pros and cons associated with both cannabis flower and concentrates with https://gas-dank.com/product-category/all-flower/premium-flower/:\n- Full spectrum of compounds: Cannabis flower contains a diverse range of cannabinoids, terpenes, and flavonoids that work together synergistically, potentially enhancing the therapeutic effects through the entourage effect.\n- Familiar consumption method: Smoking or vaporizing cannabis flower is a widely recognized and familiar method of consumption for many cannabis users.\n- Strain variety: Cannabis flower comes in a wide array of strains, each with its own unique combination of flavors, aromas, and effects, allowing users to choose strains that best suit their preferences and desired outcomes.\n- Accessibility: Cannabis flower is often widely available in legal markets and can be purchased at dispensaries or through regulated channels.\n- Respiratory health risks: Smoking cannabis flower can potentially have negative effects on respiratory health, similar to smoking tobacco. Inhalation methods can irritate the lungs and increase the risk of respiratory issues.\n- Inconsistent dosing: The potency of cannabis flower can vary from strain to strain and even among different batches of the same strain, making it more challenging to achieve consistent dosing.\n- Short duration of effects: The effects of cannabis flower typically last for a shorter duration compared to other forms of consumption, requiring more frequent dosing for sustained relief.\n- Potency: Cannabis concentrates, such as oils, waxes, shatter, or tinctures, can have significantly higher concentrations of cannabinoids than cannabis flower, providing a more potent and targeted experience.\n- Diverse consumption methods: Concentrates can be consumed in various ways, including vaping, dabbing, or incorporating them into edibles or topicals, offering a broader range of consumption options.\n- Precise dosing: Concentrates often come with clear labeling indicating the cannabinoid content, allowing for more accurate and consistent dosing.\n- Discreetness: Some concentrate consumption methods, such as vaping or using tinctures, can be more discreet and produce less odor compared to smoking cannabis flower.\n- Increased tolerance and potency: The high potency of concentrates can lead to increased tolerance over time, potentially requiring larger doses to achieve the desired effects.\n- Extraction methods and safety: The process of extracting concentrates can involve the use of solvents, which may pose safety concerns if not done properly. It’s crucial to ensure that concentrates are obtained from reputable sources that adhere to safe extraction practices.\n- Limited strain variety: Concentrates often lack the nuanced flavors and aromas found in cannabis flower since some of the terpenes and other compounds can be lost during the extraction process.\n- Accessibility and legal considerations: Depending on the legal status of cannabis in a particular jurisdiction, access to cannabis concentrates may be more restricted compared to cannabis flower.\nIt’s essential to consider personal preferences, health factors, legal regulations, and individual tolerance levels when deciding between cannabis flower and concentrates. It’s also recommended to consult with healthcare professionals or budtenders at dispensaries for personalized guidance on suitable consumption methods.", "domain": "chemistry", "round": 3} +{"url": "https://megancoulter.world.edu/2023/02/13/what-is-a-36v-lithium-battery/", "date": "2023-03-24T19:29:15Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-14/segments/1679296945288.47/warc/CC-MAIN-20230324180032-20230324210032-00222.warc.gz", "language_score": 0.949019730091095, "token_count": 677, "dump": "CC-MAIN-2023-14", "global_id": "webtext-fineweb__CC-MAIN-2023-14__0__86122609", "lang": "en", "text": "36V lithium battery is a battery that is used to power electric bicycles, some hybrid scooters, and some other electronic devices. It comes in various sizes but usually ranges between 36 and 72 volts. Lithium-ion batteries are more powerful, lighter, and safer than most common batteries for use in motorcycles, e-bikes, and scooters. The battery does not have a memory effect so it can be charged from any level without disrupting the capacity of the battery.\nHow Does A 36v Lithium Battery Work?\nThe 36V lithium battery has a 15 to 30 miles range, depending on terrain conditions. There is no fuel tank, so you don’t have to worry about gas fumes or oil spills. You can park the bike anywhere without having to worry about fuel leaks or rusting metal components (which are common in gas-powered bikes). The battery is maintenance-free and lasts for up to 5 years.\nWhat Are The Advantages Of A 36v Lithium Battery?\nThe advantages of a 36V lithium battery include longer cycle life, high charge efficiency, and quick charging. Compared with lead-acid batteries with similar power characteristics, 36V lithium battery are more cost-effective because they have no self-discharge, less weight than lead-acid batteries, longer life span, and have higher power density.\nThe 36V lithium battery is a long and slim type of Lithium Ion battery pack. A high energy density and high power density come with this battery, making it ideal for use in electric vehicles or motorcycles. 36 volts provides a higher energy capacity than standard lead-acid batteries, which means that you can start and charge your electric bike or motorcycle quicker than if you were using an older style of lead-acid batteries.\nCan I Charge My 36v Lithium Battery At Home?\nThe 36V lithium battery is rated at 4.8AH, so you can usually charge it at home with a standard AC power supply. That being said, most 36-volt battery packs draw a lot of power and regulate their voltage output more tightly than the more common lead-acid batteries do, so using a standard charger on these batteries may not give them enough power to keep up with their demands.\nHow Often Should A 36v Lithium Battery Be Charged?\nBatteries are rated at the amount of charge they can hold, and an ideal battery would give you 100% of its rated capacity. However, most batteries don’t come from the factory fully charged, so depending on how discharged it is when you receive it, a 36V lithium battery may only be capable of about 80%-90% of its rated capacity.\nWhat Can You Do With A 36v Battery?\nA 36V battery offers a great deal of versatility and flexibility for everything from electric scooters and motorcycles to portable power tools, backup phone chargers, and more in between. It’s most commonly found in small-scale electric vehicles (EVs), such as light electric vehicles, golf carts, and utility vehicles.\nThe battery is the most important part of an electric vehicle and fortunately, this battery is an excellent choice to use with your e-bikes. The 36V lithium battery can be used for different car models which definitely makes it one of the best choices for any kind of vehicle.", "domain": "chemistry", "round": 3} +{"url": "https://rebus.us.edu.pl/handle/20.500.12128/215", "date": "2022-05-25T07:37:47Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-21/segments/1652662580803.75/warc/CC-MAIN-20220525054507-20220525084507-00031.warc.gz", "language_score": 0.7413570880889893, "token_count": 480, "dump": "CC-MAIN-2022-21", "global_id": "webtext-fineweb__CC-MAIN-2022-21__0__232313375", "lang": "en", "text": "|Title:||Complex lasso : new entangled motifs in proteins|\nSułkowska, Joanna I.\n|Keywords:||complex lassos; proteins|\n|Citation:||Scientific Reports, Vol. 6 (2016), art. no 36895|\n|Abstract:||We identify new entangled motifs in proteins that we call complex lassos. Lassos arise in proteins with disulfide bridges (or in proteins with amide linkages), when termini of a protein backbone pierce through an auxiliary surface of minimal area, spanned on a covalent loop. We find that as much as 18% of all proteins with disulfide bridges in a non-redundant subset of PDB form complex lassos, and classify them into six distinct geometric classes, one of which resembles supercoiling known from DNA. Based on biological classification of proteins we find that lassos are much more common in viruses, plants and fungi than in other kingdoms of life. We also discuss how changes in the oxidation/reduction potential may affect the function of proteins with lassos. Lassos and associated surfaces of minimal area provide new, interesting and possessing many potential applications geometric characteristics not only of proteins, but also of other biomolecules.|\n|Appears in Collections:||Artykuły (WNŚiT)|\n|Niemyska_Complex_lasso.pdf||808,07 kB||Adobe PDF||View/Open|\nUznanie Autorstwa 3.0 Polska Creative Commons License", "domain": "chemistry", "round": 3} +{"url": "https://gropower.com/erosion-control/", "date": "2024-02-25T02:57:00Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707947474573.20/warc/CC-MAIN-20240225003942-20240225033942-00559.warc.gz", "language_score": 0.9114511013031006, "token_count": 315, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__99494980", "lang": "en", "text": "Landscape – Revegetation – Restoration\nThe establishment and sustained growth of plant material is usually the prime consideration when seeding for erosion control and revegetation. Mulches, BFM’s, Blankets and Mats are all temporary measures to stablize the site long enough to establish permanent vegetation, which is really the ONLY form of long term erosion control.\nFrequently, the site involves poor soils, sterile sub-soils and soils with little or no biological activity. Ordinary chemical fertilizers can be rendered useless when the soil lacks the basic building blocks. All Gro-Power Products are designed to enhance the microbiological enviornment which helps increase the fertility of the soil.\nThe distinctive difference with all Gro-Power Products is that they work on the soil as a conditioner, and provide nutrients for the plant material. Gro-Power Products are registered as a Soil Conditioner/Fertilizer combination.\nOur base is a true Humus, composted beyond the fibrous state, that does not contain any animal, poultry or human waste, therefore avoiding the potential for heavy metals, salts, odor, and other contaminants. The Humic Acids in our products help increase the cation exchange capacity which helps put nutrients in an available form that the plant can use. Also included in all Gro-Power Products are a proprietary blend of beneficial soil bacteria. Completing the products with nitrogen, phosphorus, potassium, micro-nutrients, and a soil penetrant provides a broad spectrum approach to the plant and growing medium.", "domain": "chemistry", "round": 3} +{"url": "http://www.labome.org/gene/cow/akr1c4-282138.html", "date": "2018-11-20T01:04:44Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-47/segments/1542039746171.27/warc/CC-MAIN-20181119233342-20181120015342-00355.warc.gz", "language_score": 0.7898209691047668, "token_count": 622, "dump": "CC-MAIN-2018-47", "global_id": "webtext-fineweb__CC-MAIN-2018-47__0__155053678", "lang": "en", "text": "Gene Symbol: AKR1C4\nDescription: aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)\nAlias: AKR1C1, dihydrodiol dehydrogenase 3, aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase), prostaglandin F synthase\n- Kuchinke W, Barski O, Watanabe K, Hayaishi O. A lung type prostaglandin F synthase is expressed in bovine liver: cDNA sequence and expression in E. coli. Biochem Biophys Res Commun. 1992;183:1238-46 pubmedUsing the cDNA of bovine lung prostaglandin F synthase (EC 18.104.22.168) as a probe, we isolated a clone from a bovine liver cDNA library which differed in only eleven nucleotides from the probe...\n- Suzuki T, Fujii Y, Miyano M, Chen L, Takahashi T, Watanabe K. cDNA cloning, expression, and mutagenesis study of liver-type prostaglandin F synthase. J Biol Chem. 1999;274:241-8 pubmed..Additionally, the 5-fold increase in kcat/Km value of the N306Y mutant for PGH2 compared with the wild-type value suggests that the amino acid at 306 plays an important role in catalytic efficiency for PGH2. ..\n- Madore E, Harvey N, Parent J, Chapdelaine P, Arosh J, Fortier M. An aldose reductase with 20 alpha-hydroxysteroid dehydrogenase activity is most likely the enzyme responsible for the production of prostaglandin f2 alpha in the bovine endometrium. J Biol Chem. 2003;278:11205-12 pubmed..Our objective was to identify which prostaglandin F synthase is involved and to study its regulation in the endometrium and in endometrial primary cell cultures...\n- Watanabe K, Fujii Y, Nakayama K, Ohkubo H, Kuramitsu S, Kagamiyama H, et al. Structural similarity of bovine lung prostaglandin F synthase to lens epsilon-crystallin of the European common frog. Proc Natl Acad Sci U S A. 1988;85:11-5 pubmed..171, 297-302] and of PGF synthase show 77% identical and conservative substitutions without deletions/additions. The result suggests that European common frog lens epsilon-crystallin is identical to bovine lung PGF synthase. ..", "domain": "chemistry", "round": 3} +{"url": "http://drdcn.com/3001.html", "date": "2024-03-01T05:09:38Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707947474948.91/warc/CC-MAIN-20240301030138-20240301060138-00615.warc.gz", "language_score": 0.9480926394462585, "token_count": 441, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__117593257", "lang": "en", "text": "PE water supply pipe, the full name is polyethylene water supply pipe, is a plastic pipe commonly used in water supply systems. It has excellent physical properties and chemical stability and is widely used in construction, engineering, agriculture and other fields.\nFirst of all, one of the advantages of PE water supply pipes is their strong corrosion resistance. Because polyethylene has good acid and alkali resistance, PE water supply pipes can resist the erosion of chemical substances in the water and will not cause problems such as corrosion, aging, and scaling, ensuring the hygienic safety of the water supply.\nSecondly, PE water supply pipes have high strength and stiffness. It can withstand large water pressure and external force, is not easy to deform and break, and avoids leakage accidents caused by water pipe rupture. In addition, the flexibility and toughness of PE water supply pipes also make the installation process more convenient and faster.\nIn addition, PE water supply pipes also have excellent wear resistance and impact resistance. In water supply systems, pipelines are often in complex environments. PE water supply pipes can resist the impact and wear of external forces, extending the service life of the pipelines.\nPE water supply pipes are also lightweight, non-toxic, and odorless, comply with health standards, and will not have a negative impact on water supply quality. At the same time, PE water supply pipes have low maintenance costs, have no anti-corrosion layer and insulation layer, and do not require regular maintenance and replacement, reducing usage costs.\nHowever, PE water supply pipes also have some disadvantages. Due to the low melting point of polyethylene, PE water supply pipes are easily softened and deformed in high temperature environments, so they are not suitable for use in high temperature water supply systems. In addition, PE water supply pipes have poor UV resistance and require protective measures when used outdoors.\nTo sum up, PE water supply pipe is a plastic water supply pipe with excellent performance, which has the advantages of corrosion resistance, high strength and strong wear resistance. It is widely used in fields such as construction, engineering, and agriculture, providing reliable water supply for people’s daily lives.", "domain": "chemistry", "round": 3} +{"url": "https://hanzashop.hu/uriage-en-gb/uriage-bariederm-cica-cu-zn-mosakodogel", "date": "2022-08-15T09:58:57Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882572163.61/warc/CC-MAIN-20220815085006-20220815115006-00432.warc.gz", "language_score": 0.691489577293396, "token_count": 331, "dump": "CC-MAIN-2022-33", "global_id": "webtext-fineweb__CC-MAIN-2022-33__0__136446998", "lang": "en", "text": "The Uriage Bariéderm Cleansing Cica-Gel with Cu-Zn shower gel is a necessary part of your daily hygiene. It cleans the skin all over your body gently and carefully and gives it the hydration it needs.\n- washes the skin and gets rid of dirt\n- nourishes and cares for the skin\n- creates a rich lather while washing\n- relieves tension in the skin and protects it from irritation\nHow to use:\nApply when showering or taking a bath. Apply to the skin all over the body, then rinse with warm water.\n|Ingredients||AQUA (WATER, EAU) ● SODIUM CHLORIDE ● SODIUM LAURETH SULFATE ● SODIUM COCOYL GLUTAMATE ● DECYL GLUCOSIDE ● BUTYLENE GLYCOL ● CETEARETH-60 MYRISTYL GLYCOL ● COCO-GLUCOSIDE ● GLYCERYL OLEATE ● SODIUM METHYL COCOYL TAURATE ● COPPER GLUCONATE ● ZINC GLUCONATE ● ISOPROPYL ALCOHOL ● MANGANESE GLUCONATE ● CITRIC ACID ● PHYTOSPHINGOSINE ● ASIATICOSIDE|\n|Skin type||for sensitive, irritated skin|\n|How to use||Lather on damp skin and then rinse. Avoid contact with the eyes.|", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/cytosolic-phospholipase-a2-phospho-s505-antibody-epr18552-ab191605.html", "date": "2020-03-30T16:57:27Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-16/segments/1585370497171.9/warc/CC-MAIN-20200330150913-20200330180913-00147.warc.gz", "language_score": 0.7294139266014099, "token_count": 1271, "dump": "CC-MAIN-2020-16", "global_id": "webtext-fineweb__CC-MAIN-2020-16__0__120736108", "lang": "en", "text": "Product nameAnti-Cytosolic Phospholipase A2 (phospho S505) antibody [EPR18552]\nSee all Cytosolic Phospholipase A2 primary antibodies\nDescriptionRabbit monoclonal [EPR18552] to Cytosolic Phospholipase A2 (phospho S505)\nTested applicationsSuitable for: Dot blot, IP, WBmore details\nSpecies reactivityReacts with: Mouse\nwithin Human Cytosolic Phospholipase A2 aa 450-550 (phospho S505). The exact sequence is proprietary.\nDatabase link: P47712\n- NIH/3T3 treated with 20 ng/ml TNF-alpha for 10 minutes whole cell lysate.\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\n- - High batch-to-batch consistency and reproducibility\n- - Improved sensitivity and specificity\n- - Long-term security of supply\n- - Animal-free production\nOur RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.\nStorage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.\nStorage bufferPreservative: 0.01% Sodium azide\nConstituents: 59% PBS, 40% Glycerol, 0.05% BSA\nConcentration information loading...\nPurityProtein A purified\n- Pathways and Processes\n- Metabolic signaling pathways\n- Lipid and lipoprotein metabolism\n- Lipoprotein metabolism\nOur Abpromise guarantee covers the use of ab191605 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\n|WB||1/2000. Detects a band of approximately 100 kDa (predicted molecular weight: 85 kDa).|\nFunctionSelectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response.\nTissue specificityExpressed in various tissues such as macrophages, platelets, neutrophils, fibroblasts and lung endothelium.\nSequence similaritiesContains 1 C2 domain.\nContains 1 PLA2c domain.\nDomainThe N-terminal C2 domain associates with lipid membranes upon calcium binding. It modulates enzyme activity by presenting the active site to its substrate in response to elevations of cytosolic Ca(2+).\nmodificationsActivated by phosphorylation at both Ser-505 and Ser-727.\nCellular localizationCytoplasm. Cytoplasmic vesicle. Translocates to membrane vesicles in a calcium-dependent fashion.\n- Information by UniProt\n- Calcium dependent phospholipid binding protein antibody\n- CPLA 2 antibody\n- cPLA2 alpha antibody\nAll lanes : Anti-Cytosolic Phospholipase A2 (phospho S505) antibody [EPR18552] (ab191605) at 1/2000 dilution\nLane 1 : Untreated NIH/3T3 (Mouse embryonic fibroblast cell line) whole cell lysate\nLane 2 : NIH/3T3 (Mouse embryonic fibroblast cell line) treated with 20 ng/ml TNF-alpha for 10 minutes whole cell lysate\nLysates/proteins at 20 µg per lane.\nAll lanes : Goat Anti-Rabbit IgG H&L (HRP) (ab97051) at 1/100000 dilution\nPredicted band size: 85 kDa\nObserved band size: 100 kDa why is the actual band size different from the predicted?\nExposure time: 10 seconds\nBlocking/Dilution buffer: 5% NFDM/TBST.\nab191605 at 1/50 dilution immunoprecipitating Cytosolic Phospholipase A2 (phospho S505) in NIH/3T3 (mouse embryo) whole cell lysate.\nLane 1 (input): NIH/3T3 cells treated with 20ng/ml TNF-a for 60min whole cell lysate 10μg\nLane 2 (+): ab191605 + NIH/3T3 cells treated with 20ng/ml TNF-a for 60min whole cell lysate\nLane 3 (-): Rabbit monoclonal IgG (ab172730) instead of ab191605 in NIH/3T3 cells treated with 20ng/ml TNF-a for 60min whole cell lysate\nFor western blotting, ab191605 1/1000 dilution and VeriBlot for IP Detection Reagent (HRP) (ab131366), was used for detection at 1/1000 dilution.\nBlocking and Diluting buffer and concentration: 5% NFDM/TBST.\nDot blot analysis of Cytosolic Phospholipase A2 (phospho S505) phospho peptide (Lane 1) and Phospholipase A2 Non-phospho peptide (Lane 2) labeled using ab191605 at 1/1000 dilution, followed by Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated (ab97051) secondary antibody at 1/100000 dilution.\nBlocking/Dilution buffer: 5% NFDM/TBST.\nExposure time: 3 minutes.\nab191605 has not yet been referenced specifically in any publications.", "domain": "chemistry", "round": 3} +{"url": "https://www.differencebetween.com/difference-between-coking-coal-and-thermal-coal/", "date": "2024-03-04T19:22:47Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707947476464.74/warc/CC-MAIN-20240304165127-20240304195127-00879.warc.gz", "language_score": 0.947752833366394, "token_count": 840, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__45332938", "lang": "en", "text": "The key difference between coking coal and thermal coal is that coking coal is mainly used to produce high-quality coke, whereas thermal coke is important in producing electricity.\nCoal is a type of sedimentary rock that is combustible. It appears in black or brownish-black colour. Mostly, coal contains carbon and variable amounts of other chemical elements such as hydrogen, sulfur, oxygen, and nitrogen. There are different types of coal, such as peat, lignite, sub-bituminous coal, bituminous coal, etc. depending on the composition. Also, we can categorize coal into different types according to the application; thermal coal and coking coal are two such categories.\nWhat is Coking Coal?\nCoking coal is a type of coal that is important in making high-quality coke. It is also called metallurgical coal. This substance is an essential fuel and is useful as a reactant in the blast furnace process of primary steelmaking. Therefore, the demand for this type of coal is parallel to that of steel. Due to the same reason, steel making companies have a division that produces coking coal in order to get a low-cost supply for their steel production process.\nCoking coal has a low ash content, low moisture content and low sulfur and phosphorous contents. We can categorize coking coal as a type of bituminous coal depending on the chemical composition. This type of coal can produce strong and low-density coke when it is heated in the presence of a low oxygen environment. During this heating process, coking coal softens. The volatile components tend to evaporate, and these components then escape through pores in the coal mass.\nDuring the process of coking (production of coke from coking coal), the material tends to swell and its volume increases. The ability of coking coal to form coke relates to its physical properties such as the rank of coal. In contrast to coking coal, thermal coal cannot produce coke when the material is heated.\nThe term caking ability describes coking coal because it refers to the suitability of coal to be converted into coke. There are different types of coking coal, including hard coking coal, medium coking coal, semi-soft coking coal, and pulverized coal.\nWhat is Thermal Coal?\nThermal coal is a type of coal that is mainly used for the generation of power. This type of coal can produce electricity upon heating. Thermal coal is also named as steam coal. This type of coal plays a vital role in electricity generation worldwide. This material is the source of heat for about 40% of the electricity generation globally.\nHowever, due to various environmental considerations, the use of thermal coal is limited now. It has become a major cause of global warming. As an evaluation, back in 2014, thermal coal peaked in electricity generation, and it is estimated that this usage will come to a terminal at around 2050 if we attempt to limit global warming. As a result, most of the companies have stopped investing in new thermal coal productions.\nWhat is the Difference Between Coking Coal and Thermal Coal?\nWe can categorize coal into different groups depending on the application. Thermal coal and coking coal are two such types of coal. The key difference between coking coal and thermal coal is that coking coal is mainly used to produce high-quality coke, whereas thermal coke is important in producing electricity. Thermal coal is highly produced and has a low cost while thermal coal usage is limited due to environmental considerations.\nBelow infographic summarizes the difference between coking coal and thermal coal.\nSummary – Coking Coal vs Thermal Coal\nCoal can be categorized into different groups depending on the application. Thermal coal and coking coal are two such types of coal. The key difference between coking coal and thermal coal is that coking coal is mainly used to produce high quality coke, whereas thermal coke is important in producing electricity.\n1. How Is Steel Produced? 6 Dec. 2019, Worldcoal.org, Available here.", "domain": "chemistry", "round": 3} +{"url": "https://www.ars.usda.gov/research/publications/publication/?seqNo115=390475", "date": "2024-04-22T09:50:15Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712296818105.48/warc/CC-MAIN-20240422082202-20240422112202-00309.warc.gz", "language_score": 0.9481694102287292, "token_count": 1276, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__142019510", "lang": "en", "text": "|Heuschele, Deborah - Jo\nSubmitted to: Frontiers in Genetics\nPublication Type: Peer Reviewed Journal\nPublication Acceptance Date: 12/23/2021\nPublication Date: 3/14/2022\nCitation: Pinson, S.R., Heuschele, D.J., Edwards, J., Jackson, A.K., Sharma, S., Barnaby, J.Y. 2022. Relationships among arsenic-related traits, including grain arsenic concentration and rice straighthead resistance, as revealed by genome-wide association. Frontiers in Genetics. https://doi.org/10.3389/fgene.2021.787767.\nInterpretive Summary: There is global concern about the level of arsenic contained in rice grains. While a survey by the US FDA of more than 1000 samples of rice and rice products produced in the USA determined that US-produced rice is safe for human consumption, only a portion of their samples met the more stringent, lower limit on arsenic required for baby foods. Arsenic is of higher concern in rice than other grain crops because rice is typically produced under flooded field conditions, creating an environment that makes some compounds, including arsenic, more available for plant uptake. Arsenic is also toxic to plants, and causes a disorder in rice known as straighthead, so named because it reduces grain production to the degree that the sterile (seedless) panicles remain erect rather than bending over due to weight of grains. We know that some rice varieties are more susceptible to straighthead than others, and existence of genetic variation in straighthead resistance suggests that rice has evolved genes and mechanisms that reduce the arsenic toxicity in some way. For example, either through reduced arsenic uptake, or detoxification inside the plant. Because these mechanisms would also be expected to reduce the accumulation of arsenic in rice grains, we hypothesized that some mapped genes/QTLs affecting straighthead would also impact grain-arsenic. Because silica and phosphorus are known to affect arsenic uptake, while sulfur, calcium, and copper can reduce cellular damage from arsenic toxicity, we identified and compared the chromosomal locations of genes affecting these elements as well. While we did find some shared straightead and arsenic related genes, they were not as common as our hypothesis predicted. We had also predicted that we would find silica to be more commonly associated with arsenic genes than with straighthead genes because we hypothesized that silica would impact straighthead by first affecting arsenic uptake. Once again, our results were contrary to our hypothesis, and we found numerous instances where straighthead and silica genes coincided but without a coincident effect on arsenic. These results indicate that straighthead resistance involves some mechanisms that affect grain arsenic, but involves additional mechanisms independent of arsenic. The frequency of co-location of straighthead and silica QTLs further indicates that silica might be causing some of these non-arsenic associations. It is known that silica can enhance the ability of plants to uptake elements in addition to arsenic. Silica is also known to help plants produce antioxidants, which help reduce cell damage caused by the reactive oxygen species (ROS) that otherwise accumulate in stressed cells and plants. Thus, the genes/QTL we did fine for arsenic, straighthead, and silica in rice remain useful to breeders and scientists desiring to create new rice varieties with improved grain nutritional value as well as increased resistance to straighthead disorder.\nTechnical Abstract: There is global concern that rice grains and foods can contain harmful amounts of arsenic (As), motivating breeders to produce cultivars that restrict As accumulation in grains to protect human health. Arsenic is also toxic to plants, with straighthead disorder (StHD), causing panicle sterility, being observed in rice. Genetic variation in StHD resistance suggests that plants have evolved mechanisms that reduce As toxicity, possibly via regulation of As uptake, transport, or detoxification/sequestration. Because these mechanisms could also underlie the wide (3 to 100-fold) differences in grain-As observed among diverse rice genotypes, it was hypothesized that some genes reduce both grain-As content and StHD susceptibility, and maybe detectable as co-located StDH and As quantitative trait loci (QTL). We used a machine-learning Bayesian network approach along with high resolution genome wide association study (GWAS) to identify QTL for grain-As and StHD resistance within the USDA Rice Minicore Collection (RMC). Arsenic enters roots through phosphorus (P) and silica (Si) transporters, As-detoxification involves S, and cell signaling to to tolerate abiotic stress is impacted by Si, Ca, and Cu. Therefore, concentrations of Si, P, S, Ca, and Cu were included in this study to elucidate physiological mechanisms underlying grain-As and StHD QTL. Multiple QTL (from 9 to 33) were identified for each of the investigated As-associated traits. Although the QTL we identified for StHD, grain-As and hull-Si were not as overlapped as our hypothesis predicted (4/33 StHD and 4/15 As QTL co-located), they do provide useful guidance to future research. Furthermore, these are the first StHD and Si QTL to be identified using high-density mapping, resulting in their being mapped to shorter, more precise genomic regions than previously reported QTL. The candidate genes identified also provide guidance for future research, such as gene editing or mutation studies to further investigate the role antioxidants and improved ROS scavenging to StHD resistance, as indicated by candidate genes around qStHD8-2, and as has been documented for other abiotic stresses. Other genes indicated for future study for improving grain-As and StHD include several Multidrug And Toxin Efflux (MATE) genes, F-box genes, and NIPs not documented to date to transport As.", "domain": "chemistry", "round": 3} +{"url": "https://www.affordableihcinstruments.com/product/napsin-a-rmab/", "date": "2024-02-26T13:50:00Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707947474660.32/warc/CC-MAIN-20240226130305-20240226160305-00828.warc.gz", "language_score": 0.850814700126648, "token_count": 283, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__169402161", "lang": "en", "text": "IHC of Napsin on an FFPE Lung Adenocarcinoma Tissue\n|For In Vitro Diagnostic Use\n|Summary and Explanation\n|The activation peptides of aspartic proteinases play a role as inhibitors of the active site. These peptide segments, or pro-parts, are deemed important for correct folding, targeting, and control of the activation of aspartic proteinase zymogens. The pronapsin A gene is expressed predominantly in lung and kidney. Its translation product is predicted to be a fully functional glycosylated aspartic proteinase precursor containg an RGD motif and an addition 18 residues at its C-terminus.\nIn normal tissue, anti-Napsin A labels type II pneumocytes in adult lung and epithelial cells in kidney tissues. In abnormal tissues, Napsin A is a useful marker for lung adenocarcinoma.\n|Kidney, Lung, Lung Carcinoma, Renal Cell Carcinoma\n|Napsin A is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.\n|Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.", "domain": "chemistry", "round": 3} +{"url": "https://repub.eur.nl/pub/88013", "date": "2023-06-07T05:55:55Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-23/segments/1685224653608.76/warc/CC-MAIN-20230607042751-20230607072751-00751.warc.gz", "language_score": 0.8401207327842712, "token_count": 785, "dump": "CC-MAIN-2023-23", "global_id": "webtext-fineweb__CC-MAIN-2023-23__0__260894600", "lang": "en", "text": "Morbidly Obese Patients Exhibit Increased CYP2E1-Mediated Oxidation of Acetaminophen\nClinical Pharmacokinetics , Volume 55 - Issue 7 p. 833- 847\nIntroduction: Acetaminophen (paracetamol) is mainly metabolized via glucuronidation and sulphation, while the minor pathway through cytochrome P450 (CYP) 2E1 is held responsible for hepatotoxicity. In obese patients, CYP2E1 activity is reported to be induced, thereby potentially worsening the safety profile of acetaminophen. The aim of this study was to determine the pharmacokinetics of acetaminophen and its metabolites (glucuronide, sulphate, cysteine and mercapturate) in morbidly obese and non-obese patients. Methods: Twenty morbidly obese patients (with a median total body weight [TBW] of 140.1 kg [range 106–193.1 kg] and body mass index [BMI] of 45.1 kg/m2 [40–55.2 kg/m2]) and eight non-obese patients (with a TBW of 69.4 kg [53.4–91.7] and BMI of 21.8 kg/m2 [19.4–27.4]) received 2 g of intravenous acetaminophen. Fifteen blood samples were collected per patient. Population pharmacokinetic modelling was performed using NONMEM. Results: In morbidly obese patients, the median area under the plasma concentration–time curve from 0 to 8 h (AUC0–8h) of acetaminophen was significantly smaller (P = 0.009), while the AUC0–8h ratios of the glucuronide, sulphate and cysteine metabolites to acetaminophen were significantly higher (P = 0.043, 0.004 and 0.010, respectively). In the model, acetaminophen CYP2E1-mediated clearance (cysteine and mercapturate) increased with lean body weight [LBW] (population mean [relative standard error] 0.0185 L/min [15 %], P < 0.01). Moreover, accelerated formation of the cysteine and mercapturate metabolites was found with increasing LBW (P < 0.001). Glucuronidation clearance (0.219 L/min [5 %]) and sulphation clearance (0.0646 L/min [6 %]) also increased with LBW (P < 0.001). Conclusion: Obesity leads to lower acetaminophen concentrations and earlier and higher peak concentrations of acetaminophen cysteine and mercapturate. While a higher dose may be anticipated to achieve adequate acetaminophen concentrations, the increased CYP2E1-mediated pathway may preclude this dose adjustment.\n|Organisation||Department of Intensive Care|\nvan Rongen, A, Välitalo, P.A.J, Peeters, M.Y, Boerma, D, Huisman, F.W, van Ramshorst, B, … Knibbe, C.A.J. (2016). Morbidly Obese Patients Exhibit Increased CYP2E1-Mediated Oxidation of Acetaminophen. Clinical Pharmacokinetics, 55(7), 833–847. doi:10.1007/s40262-015-0357-0\n|pubmedcentral Author Manuscript|", "domain": "chemistry", "round": 3} +{"url": "http://ttr.stoynev.us/mesterolone-hpta.html", "date": "2018-08-22T07:30:40Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-34/segments/1534221219692.98/warc/CC-MAIN-20180822065454-20180822085454-00272.warc.gz", "language_score": 0.9293567538261414, "token_count": 275, "dump": "CC-MAIN-2018-34", "global_id": "webtext-fineweb__CC-MAIN-2018-34__0__109138112", "lang": "en", "text": "The Mesterolone hormone is not estrogenic. It does not aromatize and it carries no progestin nature. As a result, the side effects of Proviron will not include any related effects such as gynecomastia or excess water retention. Such adverse effects are impossible with this steroid. This will also greatly reduce the risk of high blood pressure as high blood pressure associated with anabolic steroid use is often due to extreme water retention. In fact, Proviron should provide an anti-estrogenic effect by preventing testosterone to estrogen conversion or at least tremendously slow it down.\nDifferent testosterone esters are often blended into one injectable preparation. In some cases up to seven esters are used, but the most popular formulation is that of Sustanon 250 where four esters are mixed together. This is done to take advantage of the faster acting esters while still only requiring weekly or bi-weekly injections. It is often believed to be a superior form of testosterone, but in reality it’s nothing more than just testosterone. One drawback of testosterone blends are that they incorporate esters with long carbon chains and those chains occupy allot of molecular weight, so the actual dosage of hormone is less than one would obtain from shorter esters like propionate. Testosterone blends are most useful during bulking phases where frequent injections are not possible.", "domain": "chemistry", "round": 3} +{"url": "https://www.slideshare.net/ShellCreekWatershed/ng-shell-creek-data-powerpoint-2002", "date": "2018-04-24T13:18:04Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-17/segments/1524125946688.88/warc/CC-MAIN-20180424115900-20180424135900-00582.warc.gz", "language_score": 0.8815149664878845, "token_count": 498, "dump": "CC-MAIN-2018-17", "global_id": "webtext-fineweb__CC-MAIN-2018-17__0__235379444", "lang": "en", "text": "Researchers: Amanda Gasper, Anjuli Mostek, Jamie Lorenzen, KatieStone, Courtney Bennett, Mike Voelker, Aaron Hallgren, Instructor: Mark Seier\nMission Collect data to report to the Shell CreekWatershed Improvement Group and NebraskaWildlife Federation Learn about the geography and location of the Shell Creek and the area it involves Become knowledgeable about water chemistry parameters and their significance to the stream’s inhabitants Learn about biological stream factors and how they indicate water quality\nProceduresA total of four sites were selected and latitude andlongitude were determined by using Global PositioningSystem (GPS).Sampling was done in two day sets. First day was chemical testingand the second was macroinvertebrate sampling.Chemical tests run include: pH, water temperature,turbidity, conductivity, velocity, nitrates, dissolved oxygen,and oxygen saturationMacroinvertebrate sampling was done using a D-net andincluded 20, 1-foot square samples at each site.We also usedHester-Dendy samplers. Fish were sampled using a seine.\nWater Test Natural Readings Cautionary ReadingsDissolved Oxygen 5-14 ppm Below 5: water quality violation 1.5-5: stress resulting in abnormal feeding and reproduction 1.5: mortality 0: anoxicpH 6.5 - 8.5 Below 6.5 Above 8.5Nitrates 0.0 - 1.0 ppm Consistent readings above 3 ppmTemperature Varies Above 27o CelsiusTurbidity 0 – 8 JTU Increasing trends in turbidity measurements\nConclusions and Concerns•Low dissolved oxygen and % saturation rates•High levels of turbidity•High amounts of silt and sediment•Low macroinvertebrate diversity•Scoured banks at site 4\nSuggestions for future studies:• We would like to add the tests: fecal coliform, biochemical oxygen demand, total phosphates, and total solids; to calculate the overall water quality index number.• Continue to monitor same sites and add one or two new locations\nWe would like to thank the Shell Creek Watershed Improvement Group and theNatural Resource District for providing us with the testing materials. We would also like to thank the landownerswho owned the area around the sites we tested for their cooperation in this study: PaulCederlind, Fred Fehringer, and Katie Hallgren.", "domain": "chemistry", "round": 3} +{"url": "http://www.pierce-antibodies.com/E2F6-antibody-Polyclonal--PA513589.html", "date": "2015-10-10T19:43:42Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2015-40/segments/1443737962531.78/warc/CC-MAIN-20151001221922-00014-ip-10-137-6-227.ec2.internal.warc.gz", "language_score": 0.8941016793251038, "token_count": 479, "dump": "CC-MAIN-2015-40", "global_id": "webtext-fineweb__CC-MAIN-2015-40__0__59608761", "lang": "en", "text": "Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C\nProduct Specific Information\nPA5-13589 targets E2F6 in WB applications and shows reactivity with Human samples. The PA5-13589 immunogen is a synthetic peptide from the center region of E2F6 conjugated to KLH. PA5-13589 detects E2F6 which has a predicted molecular weight of approximately 32 kDa.\nThis gene encodes a member of the E2F transcription factor protein family. E2F family members play a crucial role in control of the cell cycle and of the action of tumor suppressor proteins. They are also a target of the transforming proteins of small DNA tumor viruses. Many E2F proteins contain several evolutionarily conserved domains: a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins, a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. The encoded protein of this gene is atypical because it lacks the transactivation and tumor suppressor protein association domains. It contains a modular suppression domain and is an inhibitor of E2F-dependent transcription. The protein is part of a multimeric protein complex that contains a histone methyltransferase and the transcription factors Mga and Max. Multiple transcript variants have been reported for this gene, but it has not been clearly demonstrated that they encode valid isoforms.\nE2F6 Antibody (PA5-13589) in WB E2F6_Antibody_PA5-13589_WB_1_112013.jpg\nWestern Blot with anti-E2F6 Polyclonal Antibody (PA5-13589)\nFlow cytometric analysis of NCI-H292 cells using anti-E2F6 Polyclonal Antibody (PA5-13589) (bottom), compared to a negative control cell (top) at a dilution of 1:10-50. Secondary antibody used to visualize was a Goat Anti-Rabbit Secondary Antibody Conjugated to FITC.\n(This product is for In Vitro experimental use only. Not for resale without express authorization.)", "domain": "chemistry", "round": 3} +{"url": "https://wwwqws.sigmaaldrich.com/US/en/product/aldrich/268569", "date": "2021-10-16T02:23:47Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-43/segments/1634323583408.93/warc/CC-MAIN-20211016013436-20211016043436-00151.warc.gz", "language_score": 0.8445904850959778, "token_count": 306, "dump": "CC-MAIN-2021-43", "global_id": "webtext-fineweb__CC-MAIN-2021-43__0__291011726", "lang": "en", "text": "Tetrahedron Letters, 30, 5607-5607 (1989)\nTetrahedron, 47, 6983-6983 (1991)\nAlexander C Kozen et al.\nACS nano, 9(6), 5884-5892 (2015-05-15)\nLithium metal is considered to be the most promising anode for next-generation batteries due to its high energy density of 3840 mAh g(-1). However, the extreme reactivity of the Li surface can induce parasitic reactions with solvents, contamination, and shuttled...\nMahtab Farzin et al.\nPathology, 47(4), 302-307 (2015-05-06)\nBRCA1-associated protein 1 (BAP1) is a tumour suppressor gene frequently inactivated in mesothelioma, rarely also in association with germline mutation. BAP1 mutations have been associated with improved prognosis and distinct clinicopathological features. We sought to determine the clinicopathological significance of...\nJ L L Robinson et al.\nOncogene, 33(50), 5666-5674 (2013-12-03)\nCastration-resistant prostate cancer (CRPC) continues to pose a significant clinical challenge with new generation second-line hormonal therapies affording limited improvement in disease outcome. As the androgen receptor (AR) remains a critical driver in CRPC, understanding the determinants of its transcriptional...", "domain": "chemistry", "round": 3} +{"url": "https://dr.lib.iastate.edu/entities/publication/85a090ec-4c14-4427-973e-53444b9827b5", "date": "2022-07-06T08:38:48Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-27/segments/1656104668059.88/warc/CC-MAIN-20220706060502-20220706090502-00113.warc.gz", "language_score": 0.904571533203125, "token_count": 687, "dump": "CC-MAIN-2022-27", "global_id": "webtext-fineweb__CC-MAIN-2022-27__0__129726022", "lang": "en", "text": "Thermal isomerization and decomposition of ethynyldisilanes\nCo-pyrolysis of ethynylpentamethyldisilane with 2,3-dimethylbutadiene afforded trimethylsilylacetylene, dimethylsily(trimethylsilyl)acetylene and 1,1,3,4-tetramethyl-1-silacyclopent-3-ene. When an alkyl or trimethylsilyl substituted ethynyl group was pyrolyzed, extrusion of dimethylsilylene was the only decomposition process observed with no isomerization. The decomposition and isomerization pathways were proposed to proceed via a silacyclopropene intermediate. Arrhenius parameters were determined for these processes by using a pulse stirred-flow reactor. The substitution on the silacyclopropene intermediate determined which pathway would be favored. When a good migrating group was on the silicon in the silacyclopropene, a vinylsilylene intermediate was also involved. The decomposition via a silacyclopropene competed with an [alpha]-elimination when both were possible;Pyrolysis of ethynylundecamethylcyclohexasilane afforded the ring-expanded isomer 3-hydridoundecamethylhexasilacyclooctyne and decamethylpentasilacycloheptyne. Pyrolysis of 4,4,5,5,6,6,7,7,8,8-decamethyl-4,5,6,7,8-pentasilacyclooctyne afforded ring-contracted isomer 1,1-penta(dimethylsilylene)propadiene, 4,4,5,5,6,6,7,7-octamethyl-4,5,6,7-tetrasilacycloheptyne, 1, and 1,1-tetra(dimethylsilylene)propadiene, 2. Cycloheptyne 1 was also pyrolyzed and afforded propadiene 2 as the only product. Several mechanisms were proposed for these decompositions and isomerizations. The pathways involving a loss of dimethylsilylene were proposed to proceed through a silacyclopropene intermediate. The isomerizations were proposed to go through a cyclopropene intermediate;Bis (1,3-tetra(dimethylsilylene)) propadiene, 3, was synthesized from cycloheptyne 1 in 20% yield. An x-ray structure of the smallest \"betweenallene\", 3, was determined. The propadiene carbons were linear and twisted 18 degrees towards planarity. Pyrolysis of propadiene 3 afforded isomer 1,1-3,3-bis(tetra(dimethylsilylene)) propadiene as the only observed product. The proposed mechanism involved cyclopropene intermediates.", "domain": "chemistry", "round": 3} +{"url": "https://www.zettex.com/products/adhesives/6-contact-adhesives/179-easycontact-s10", "date": "2023-06-01T16:23:48Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-23/segments/1685224647895.20/warc/CC-MAIN-20230601143134-20230601173134-00463.warc.gz", "language_score": 0.7880433797836304, "token_count": 338, "dump": "CC-MAIN-2023-23", "global_id": "webtext-fineweb__CC-MAIN-2023-23__0__195793309", "lang": "en", "text": "Zettex Easycontact S10 is a quick-drying universal contact adhesive applied using a brush or roller. Zettex Easycontact S10 is suitable for most materials in construction and industry. This Easycontact S10 is applied with a brush or a roller. Besides the Easyontact S10 is DCM-free.\n• Extremely powerful\n• High solid substance content\n• For universal use\n• Ready to use\n• Drum 1 KG, 2.5 KG, 5 KG , 10 KG, 25 KG, 50 KG, 200 KG and 1000 KG\n• Transparent or red.\n• For the adhesion of all kinds of carpeting, cork, linoleum, insulation material and rubber.\n• Dry the materials to be adhered and remove dust and grease. This can be done with Zettex Profireinger. Then carefully apply the contact adhesive using a brush or a roller. Preferably apply the adhesive rows without overlapping. After 2-4 minutes adhere both surfaces to each other and firmly press or roll. When there is overlapping the open time must at least be doubled. With very porous surfaces carefully check whether there is sufficient contact between both adhesive layers. Apply an extra layer if this is required.\n|| +5 to +40 degrees\n|| -40°C to +55°C", "domain": "chemistry", "round": 3} +{"url": "https://bdiezlab.com/publication/pablo_vergara-barros_et_al_2022/", "date": "2024-04-22T08:51:07Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712296818105.48/warc/CC-MAIN-20240422082202-20240422112202-00899.warc.gz", "language_score": 0.930582582950592, "token_count": 387, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__24364665", "lang": "en", "text": "Key organisms in the environment, such as oxygenic photosynthetic primary producers (photosynthetic eukaryotes and cyanobacteria), are responsible for fixing most of the carbon globally. However, they are affected by environmental conditions, such as temperature, which in turn affect their distribution. Globally, the cyanobacterium Fischerella thermalis is one of the main primary producers in terrestrial hot springs with thermal gradients up to 60 °C, but the mechanisms by which F. thermalis maintains its photosynthetic activity at these high temperatures are not known. In this study, we used molecular approaches and bioinformatics, in addition to photophysiological analyses, to determine the genetic activity associated with the energy metabolism of F. thermalis both in situ and in high-temperature (40 °C to 65 °C) cultures. Our results show that photosynthesis of F. thermalis decays with temperature, while increased transcriptional activity of genes encoding photosystem II reaction center proteins, such as PsbA (D1), could help overcome thermal damage at up to 60 °C. We observed that F. thermalis tends to lose copies of the standard G4 D1 isoform while maintaining the recently described D1INT isoform, suggesting a preference for photoresistant isoforms in response to the thermal gradient. The transcriptional activity and metabolic characteristics of F. thermalis, as measured by metatranscriptomics, further suggest that carbon metabolism occurs in parallel with photosynthesis, thereby assisting in energy acquisition under high temperatures at which other photosynthetic organisms cannot survive. This study reveals that, to cope with the harsh conditions of hot springs, F. thermalis has several compensatory adaptations, and provides emerging evidence for mixotrophic metabolism as being potentially relevant to the thermotolerance of this species. Ultimately, this work increases our knowledge about thermal adaptation strategies of cyanobacteria.", "domain": "chemistry", "round": 3} +{"url": "https://www.cheric.org/research/tech/periodicals/view.php?seq=312255", "date": "2021-04-11T15:21:48Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-17/segments/1618038064520.8/warc/CC-MAIN-20210411144457-20210411174457-00607.warc.gz", "language_score": 0.9227127432823181, "token_count": 352, "dump": "CC-MAIN-2021-17", "global_id": "webtext-fineweb__CC-MAIN-2021-17__0__3915494", "lang": "en", "text": "Journal of Applied Polymer Science, Vol.81, No.13, 3190-3197, 2001\nEffect of tacticity of poly(methyl methacrylate) on the miscibility with poly(vinyl pyrrolidone)\nIsotactic, atactic, and syndiotactic poly(methyl methacrylates) (PMMA) (designated iPMMA, aPMMA, and sPMMA) with approximately the same molecular weight were mixed separately with poly(vinyl pyrrolidone) (PVP) primarily in chloroform to make three polymer blend systems. Differential scanning calorimetry (DSC) was used to study the miscibility of these blends. The results showed that the tacticity of PMMA has a definite impact on its miscibility with PVP. The aPMMA/PVP and sPMMA/PVP blends were found to be miscible because all the prepared films showed composition-dependent glass-transition temperatures (T-g). The glass-transition temperatures of the aPMMA/PVP blends are equal to or lower than weight average and can be qualitatively described by the Gordon-Taylor equation. The glass-transition temperatures of the other miscible blends (i.e., sPMMA/PVP blends) are mostly higher than weight average and can be approximately fitted by the simplified Kwei equation. The iPMMA/PVP blends were found to be immiscible or partially miscible based on the observation of two glass-transition temperatures. The immiscibility is probably attributable to a stronger interaction among isotactic MMA segments because its ordination and molecular packing contribute to form a rigid domain.", "domain": "chemistry", "round": 3} +{"url": "http://javaprogramming.pl/journalist.php?tetracycline-hydrochloride-rats.doc", "date": "2016-05-27T18:21:00Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2016-22/segments/1464049276964.77/warc/CC-MAIN-20160524002116-00012-ip-10-185-217-139.ec2.internal.warc.gz", "language_score": 0.7301027178764343, "token_count": 1098, "dump": "CC-MAIN-2016-22", "global_id": "webtext-fineweb__CC-MAIN-2016-22__0__137316869", "lang": "en", "text": "For eczema sun sensitivity mechanism shanelopez.com tetracycline hydrochloride rats wolff kapszula. Ototoxicity in dermatology can tetracycline cure pid can be used for acne oxy not working anymore. Skin ointment dosage is available anymore tetracycline fish for humans streptomycin oxy 20. 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Oxy pills marquage and zyrtec waar zit in.", "domain": "chemistry", "round": 3} +{"url": "https://wyoscholar.uwyo.edu/articles/presentation/Methods_for_Obtaining_High_Frequency_13CO2_Measurements/13703560/3", "date": "2023-12-11T11:40:07Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679511159.96/warc/CC-MAIN-20231211112008-20231211142008-00102.warc.gz", "language_score": 0.9099475145339966, "token_count": 321, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__288558081", "lang": "en", "text": "UGRD_2015_Spring_Huhn_Bridger.pdf (430.71 kB)\nMethods for Obtaining High Frequency 13CO2 Measurements\npresentationposted on 2021-11-15, 18:18 authored by Bridger Huhn\nThe goal for this research project is to understand how plants control water use. This is crucial when accounting for the water availability of a plant and drought analysis. A plants ability to assimilate mass in comparison to how much water it uses is known as water use efficiency (WUE). A current method of determining WUE measures heavy carbon (13C) to light carbon (12C) ratios (δ13C) that come out of a plant in the form of carbon dioxide. However this method doesn't account for some metabolic processes that may affect δ13C. Accurate WUE data is important in understanding local and global carbon cycles and watersheds. Our study differs from other studies on this topic by accounting for all the carbon in a plant by using a hydroponic method I developed to grow the plants. We will use hydroponic plant chamber and controlled air sources to grow Brassica rapa (a small herbaceous plant) and measure δ13C values. This system will also allow us to conduct a complete carbon budget of this plant. This experiment will improve our understanding of mountain front hydrology, as well as how disturbances affect plants that affect water flux. It can also improve integrated modeling of the fate and transport of water.\nPublisherUniversity of Wyoming. Libraries\n- Library Sciences - LIBS", "domain": "chemistry", "round": 3} +{"url": "https://grandmasf.com/unclogging-a-sink-using-natural-ingredients/", "date": "2024-03-03T12:03:15Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707947476374.40/warc/CC-MAIN-20240303111005-20240303141005-00433.warc.gz", "language_score": 0.8400675058364868, "token_count": 444, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__194288976", "lang": "en", "text": "Unclogging a sink using natural ingredients can be an effective and environmentally friendly approach. Here’s a simple method using two common household items: baking soda and vinegar.\nBaking soda White vinegar Boiling water Rubber stopper or rag (optional) Procedure: Remove Excess Water: If there is standing water in the sink, remove as much as possible using a cup or bucket. You want to have a clear drain to allow the ingredients to work effectively. Pour Baking Soda: Start by pouring about 1/2 cup to 1 cup of baking soda down the drain. Make sure it goes directly into the drain. Pour Vinegar: After the baking soda, pour about 1/2 cup to 1 cup of white vinegar down the drain. You’ll notice a fizzing reaction as the baking soda and vinegar react. This fizzing action helps break down the clog and remove debris. Wait: Let the baking soda and vinegar mixture sit in the drain for at least 15 minutes.\nDuring this time, the chemical reaction will be working to break down the clog. Boiling Water: Carefully pour boiling water down the drain after the waiting period. This hot water will help flush away the broken-down debris. Repeat if Necessary: If the clog persists, you can repeat the process. Sometimes, tough clogs may require a few rounds of the baking soda and vinegar treatment.\nOptional: Plunge or Use a Drain Snake: If the clog persists, you can try using a plunger or a drain snake to physically remove the blockage. Make sure to follow the proper procedures for using these tools to avoid damage.\nPreventive Measures: Consider using a drain strainer to catch hair and other debris before they go down the drain.\nRegularly flushing your drains with hot water can also help prevent clogs. Remember, this method may not work for all types of clogs. If you’re dealing with a severe or persistent clog, it may be best to consult a professional plumber for assistance. Additionally, avoid using chemical drain cleaners as they can be harmful to the environment and may damage your plumbing over time.", "domain": "chemistry", "round": 3} +{"url": "https://cris.tau.ac.il/en/publications/a-combination-of-hsub2subosub2sub-and-vanadate-concomitantly-stim", "date": "2024-04-15T06:53:50Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712296816942.33/warc/CC-MAIN-20240415045222-20240415075222-00602.warc.gz", "language_score": 0.8867236971855164, "token_count": 356, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__98674937", "lang": "en", "text": "Treatment of four cell lines [rat hepatoma (Fao), murine muscle (BC3H-1), Chinese hamster ovary (CHO), and rat basophilic leukemia (RBL)] with a combination of 3 mM H2O2 and 1 mM sodium orthovanadate markedly stimulates protein tyrosine phosphorylation, which is accompanied by a dramatic increase (5-15-fold) in inositol phosphate (InsP) formation. H2O2/vanadate stimulate best formation of inositol triphosphate while their effects on the mono and di derivatives are more moderate. In the presence of 3 mM H2O2, both protein tyrosine phosphorylation and InsP formation are highly correlated and manifest an identical dose-response relationship for vanadate. Half-maximal and maximal effects are obtained at 30 and 100 μM, respectively. This stimulatory effect of H2O2/vanadate is not mimicked by other oxidants such as spermine, spermidine, KMnO4, and vitamin K3. In RBL cells, the kinetics of inositol triphosphate formation correlate with tyrosine phosphorylation of a 67-kDa protein, while tyrosine phosphorylation of a 55-kDa protein is closely correlated with both inositol monophosphate formation and serotonin secretion from these cells. Taken together, these results suggest a causal relationship between tyrosine phosphorylation triggered in a nonhormonal manner and polyphosphoinositide breakdown. Furthermore, these results implicate protein tyrosine phosphorylation in playing a role in the stimulus-secretion coupling in RBL cells.", "domain": "chemistry", "round": 3} +{"url": "https://www.cdc.gov/niosh/nioshtic-2/20027145.html", "date": "2022-10-01T22:35:33Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-40/segments/1664030336921.76/warc/CC-MAIN-20221001195125-20221001225125-00371.warc.gz", "language_score": 0.8619109392166138, "token_count": 547, "dump": "CC-MAIN-2022-40", "global_id": "webtext-fineweb__CC-MAIN-2022-40__0__253102187", "lang": "en", "text": "Activation of protein kinase C is required for silica-induced activation of the MAP kinase-AP-1 pathway.\nDing M; Lu Y; Bowman L; Huang C; Castranova V\nMed Lav 2002 Oct; 93(Suppl):S41\nSilica particles are considered to be fibrogenic agents and have been recently designated as carcinogenic, but the mechanisms for cancer initiation and progression are not well understood. By using an AP-1-luciferase reporter cell line, we demonstrated that activator protein-1 (AP-1) activation by crystalline silica is through mitogen-activated protein kinases (MAPK), i.e.,ERKs and p38 kinases. The present study investigates the role of protein kinase C (PKC) in silica-induced activation of the MAPK-AP-1 pathway. Treatment of JB6 cells with freshly fractured silica stimulated translocation of PKC*, PKC*, and PKC, from the cytosol to the membrane and activated Ap-1 activity. Rotterin (a selective inhibitor of PKC*), RO-32-0432 (a relative specific inhibitor for PKC), and calphostic C and bisindolylmaleimide I (general PKC inhibitors for all the subtypes), inhibited silica-stimulated AP-1 actication. These effects of PKC inhibitors were dose dependent. Dominate negative mutant transfectants of PKC markedly blocked AP-1 activation induced by silica. Western blot analysis using phosphor-specific antibodies indicates that PKC inhibitors or dominant negative mutant transfectants of PKC also blocked silica-induced phosphor ylation of ERKs and p38 kinase. Thses results demonstrate that PKC\", PKC*, and PKC, mediate silica induced AP-1 activation through MAP kinase (ERKs and p38 kinases) pathways.\nSilicates; Silicosis; Silica-dusts; Pulmonary-disorders; Pulmonary-function; Pulmonary-system-disorders; Fibrogenicity; Respiratory-system-disorders; Respiratory-irritants; Cellular-reactions; Cell-damage\nAbstract; Conference/Symposia Proceedings\nLa Medicina del Lavoro. 3rd International Symposium on Silica, Silicosis, Cancer and Other Diseases, S. Margherita Ligure, 21-25 October 2002", "domain": "chemistry", "round": 3} +{"url": "https://www.elsevier.com/books/hypothalamic-hormones/li/978-0-12-447207-5", "date": "2018-03-21T03:27:58Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-13/segments/1521257647567.36/warc/CC-MAIN-20180321023951-20180321043951-00413.warc.gz", "language_score": 0.7220015525817871, "token_count": 773, "dump": "CC-MAIN-2018-13", "global_id": "webtext-fineweb__CC-MAIN-2018-13__0__209902939", "lang": "en", "text": "Hypothalamic Hormones is a collection of papers that elucidates the various aspects, chemical properties, effects, and history of hypothalamic hormones.\nThe book is composed of five chapters on the detailed study of hypothalamic hormones. Chapter 1 is about a review of basic and clinical studies of corticotropin releasing factor (CRF); thyrotropin releasing hormone (TRH); prolactin releasing factor; prolactin-release inhibiting factor; factors affecting the release of melanotropin; luteinizing hormone release hormone (LHRH); growth hormone release factor; and somatostatin. The second chapter is a discussion on the various aspects of luteinizing hormone release hormone (LHRH). Subsequent chapters are concerned with the study of factors that control the secretion of growth hormone, with particular emphasis on brain neurotransmitters; the mechanism of action of hypothalamic hormones; and effects of androgens, estrogens, and other peripheral hormones on the hypothalamus function. The last chapter gives a history of neurosecretion and neuroendocrinology. Biochemists, physicians, pharmacologists, endocrinologists, researchers, and students in the medical field will find this book invaluable.\nList of Contributors Preface Contents of Previous Volumes\n- Hypothalamic Peptide Hormones: Basic and Clinical Studies I. Introduction II. Corticotropin-Releasing Factor (CRF) III. Thyrotropin-Releasing Hormone (TRH) IV. Prolactin-Releasing Factor (PRF) V. Prolactin-Release-Inhibiting Factor (PIF) VI. Factors Affecting the Release of Melanocyte-Stimulating Hormone (MSH) VII. The LH- and FSH-Releasing Hormone (LH-RH/FSH-RH) VIII. Growth Hormone-Releasing Factor (GH-RF) IX. Growth Hormone Release-Inhibiting Hormone (GH-RIH, Somatostatin) References\n- Gonadoliberin I. Introduction II. Extraction and Purification of Gonadoliberin from Different Sources III. Determination of the Primary Structure of Gonadoliberin IV. Conformational Studies on Gonadoliberin V. Chemical Syntheses of Gonadoliberin VI. Structure-Activity Relationship for Gonadoliberin VII. Gonadoliberin Biosynthesis and Biodegradation VIII. Control of Gonadoliberin Release IX. Biological Effects of Gonadoliberin X. Bioassay for Gonadoliberin XI. Immunological Studies with Gonadoliberin XII. Cellular Mechanism of Action of Gonadoliberin XIII. Agonist and Antagonist Analogues of Gonadoliberin XIV. Concluding Remarks References\n- The Control of Somatotropin Secretion I. Introduction II. Secretion Pattern of GH in Different Animal Species III. Stimuli for GH Secretion IV. Central Nervous System Control of GH Secretion V. Feedback Control of GH Secretion VI. Concluding Remarks References\n- Mechanisms of Action of Hypothalamic and Peripheral Hormones in the Anterior Pituitary Gland I. Introduction II. Role of Cyclic AMP in the Action of TRH, LH-RH, and Somatostatin III. Role of Prostaglandins in Hypothalamic Hormone Action on Adenohypophysis IV. Adenohypophyseal Cyclic AMP-Dependent Protein Ki\n- No. of pages:\n- © Academic Press 1979\n- 28th January 1979\n- Academic Press\n- eBook ISBN:", "domain": "chemistry", "round": 3} +{"url": "https://thescipub.com/abstract/ajessp.2012.202.211", "date": "2024-04-22T15:15:37Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712296818312.80/warc/CC-MAIN-20240422144517-20240422174517-00285.warc.gz", "language_score": 0.9166589975357056, "token_count": 511, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__174804594", "lang": "en", "text": "Ecological Monitoring of Danube water Quality in Budapest Region\nProblem statement: Serious health problems and other economic costs related to water treatment, remediation and locating a new water supply, become an evidence of water pollution caused by human activities. The main problems of the Danube River basin are associated with nutrients, organic pollution and hazardous pollutants. The aim of the study is to assess the surface water of the Danube in Budapest for sustainability of human and environment health. Approach: The monitoring assessment of comparative studies was carried out in June of 1998, 2005 and 2010 using the Hungarian standard methods. The samples were collected in sterile dark bottles from three different zones in Budapest. Results: The results demonstrated that dissolved organic carbon content, nutrient pollution (total N and P), bacteriological parameters and chlorophyll-a content were higher in 2005 than in 1998 and 2010. The results indicated that the bacteriological assessments and bacterial populations were low in 1998 in comparison with the results of 2010. In 2005, investigations illustrate the high fecal pollution. The data showed no significant differences between temperature, pH and Electrical conductivity in 1998, 2005 and 2010. Conclusion/Recommendations: Monitoring of the water by physicochemical and bacteriological is essential to identify the aquatic ecosystem hazards. The relation between O2 and Chl-a content of the samples, clearly shows that the cause of high dissolved O2 content in the water lies in accelerated primary production. Enumerations of both total and fecal Coliforms are continuously growing during the investigation periods. These results suggested that bacteriological properties can be a specific indicator of fecal contamination and organic pollution. With large numbers of new chemical substances entering the river ecosystem, continuous monitoring systems for their detection will become increasingly important with respect to environmental effects they produce, in addition to other toxic effects. The challenges to continuous physical, chemical, biological and bacteriological monitoring will be immense.\nCopyright: © 2012 Hosam E.A.F. Bayoumi Hamuda and Istvan Patko. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.\n- 4,203 Views\n- 4,431 Downloads\n- 18 Citations\n- Ecological monitoring\n- danube river water quality\n- physicochemical parameters", "domain": "chemistry", "round": 3} +{"url": "http://www.water-chemistry.in/2009/06/trickling-filter-process-calculations/", "date": "2023-06-04T23:20:13Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-23/segments/1685224650409.64/warc/CC-MAIN-20230604225057-20230605015057-00633.warc.gz", "language_score": 0.9062477946281433, "token_count": 353, "dump": "CC-MAIN-2023-23", "global_id": "webtext-fineweb__CC-MAIN-2023-23__0__126886311", "lang": "en", "text": "The trickling filter process (see Figure Below) is one of the oldest forms of dependable biological treatment for wastewater. By its very nature, the trickling filter has advantages over other unit processes. For example, it is a very economical and dependable process for treatment of wastewater prior to discharge. Capable of withstanding periodic shock loading, process energy demands are low because aeration is a natural process.\nthe trickling filter operation involves spraying wastewater over a solid media such as rock, plastic, or redwood slats (or laths).As the wastewater trickles over the surface of the media, a growth of microorganisms (bacteria,protozoa, fungi, algae, helminthes or worms, and larvae) develops. This growth is visible as a shiny slime very similar to the slime found on rocks in a stream. As wastewater passes over this slime,the slime adsorbs the organic (food) matter.This organic matter is used for food by the microorganisms.At the same time, air moving through the open spaces in the filter transfers oxygen to the wastewater. This oxygen is then transferred to the slime to keep the outer layer aerobic. As the microorganisms use the food and oxygen, they produce more organisms, carbon dioxide, sulfates,nitrates, and other stable byproducts; these materials are then discarded from the slime back into the wastewater flow and are carried out of the filter. various process calculations,\nA trickling filter that is 80 ft in diameter treats a primary effluent flow of 550,000 gpd. If the recirculated flow to the clarifier is 0.2 MGD, what is the hydraulic loading on the trickling filter?\nLeave a Reply", "domain": "chemistry", "round": 3} +{"url": "https://www.fightaging.org/archives/2011/05/calorie-restriction-and-nitric-oxide/", "date": "2021-05-14T03:51:16Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-21/segments/1620243991737.39/warc/CC-MAIN-20210514025740-20210514055740-00576.warc.gz", "language_score": 0.9101459980010986, "token_count": 333, "dump": "CC-MAIN-2021-21", "global_id": "webtext-fineweb__CC-MAIN-2021-21__0__58370616", "lang": "en", "text": "An open access paper in which researchers delve into the mechanisms of longevity induced through calorie restriction in yeast: \"Calorie restriction (CR) induces a metabolic shift towards mitochondrial respiration; however, molecular mechanisms underlying CR remain unclear. Recent studies suggest that CR-induced mitochondrial activity is associated with nitric oxide (NO) production. To understand the role of mitochondria in CR, we identify and study Saccharomyces cerevisiae mutants with increased NO levels as potential CR mimics. Analysis of the top 17 mutants demonstrates a correlation between increased NO, mitochondrial respiration, and longevity. Interestingly, treating yeast with NO donors such as GSNO (S-nitrosoglutathione) is sufficient to partially mimic CR to extend lifespan. ... . Our results suggest that CR may derepress some hypoxic genes for mitochondrial proteins that function to promote the production of NO and the extension of lifespan. ... CR-induced NO production may extend lifespan by increasing the stress response (mitohormesis). Our study may have uncovered potential novel components in the CR pathway and provided tools to analyze the interconnections between NO, mitochondrial respiration, CR, and longevity. Although the CR mimics identified in this study share similar NO levels, lifespan, and oxygen consumption phenotypes with CR, they may activate NO production and regulate mitochondrial respiration and lifespan via different mechanisms. It will be enlightening to examine these differences in future studies. Finally, we propose that CR likely confers its beneficial effects via a mitochondria-NO-mediated adaptive metabolic shift, which optimizes metabolism and at the same time improves cellular defense system against the oxidative stress that accumulates with age.\"", "domain": "chemistry", "round": 3} +{"url": "https://scholars.duke.edu/display/pub692064", "date": "2021-10-23T19:01:34Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-43/segments/1634323585737.45/warc/CC-MAIN-20211023162040-20211023192040-00052.warc.gz", "language_score": 0.855194091796875, "token_count": 285, "dump": "CC-MAIN-2021-43", "global_id": "webtext-fineweb__CC-MAIN-2021-43__0__234048381", "lang": "en", "text": "Barbiturate and picrotoxin-sensitive chloride efflux in rat cerebral cortical synaptoneurosomes.\nThe effects of various barbiturates and picrotoxin in modifying the efflux of chloride (36Cl-) was studied in a novel subcellular preparation from rat cerebral cortex, the 'synaptoneurosome'. Dilution of synaptoneurosomes pre-loaded with 36Cl- resulted in rapid efflux of 36Cl- that could be measured as early as 10 s following dilution. In the presence of barbiturates such as pentobarbital and hexobarbital there was a significant increase in 36Cl- efflux which was not observed with the pharmacologically-inactive barbiturate, barbital. The effect of barbiturates in enhancing 36Cl- efflux was also stereospecific [(-)-DMBB greater than (+)-DMBB] and reversed by picrotoxin. By contrast, picrotoxin alone significantly inhibited 36Cl- efflux. These data demonstrate pharmacologically relevant Cl- transport for the first time in a subcellular brain preparation.\nSchwartz, RD; Skolnick, P; Hollingsworth, EB; Paul, SM\nVolume / Issue\nStart / End Page\nInternational Standard Serial Number (ISSN)\nDigital Object Identifier (DOI)", "domain": "chemistry", "round": 3} +{"url": "https://www.scientific.net/KEM.359-360.409", "date": "2019-01-21T03:46:02Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-04/segments/1547583755653.69/warc/CC-MAIN-20190121025613-20190121051613-00475.warc.gz", "language_score": 0.9197736978530884, "token_count": 378, "dump": "CC-MAIN-2019-04", "global_id": "webtext-fineweb__CC-MAIN-2019-04__0__55663916", "lang": "en", "text": "Fabrication of WC-6Co-1.5Al (wt%) Hardmetal by High Energy Milling and Electrical Current Sintering\nUltrafine grain WC hardmetals were manufactured successfully from mixed powders of nominal composition of WC-6Co-1.5Al(wt%). To manufacture bulk ultrafine grain WC alloys, nanocrystalline WC powders as precursor were prepared for sintering from the mixed commercially available powders by high energy milling of 15 h. Then the electrical current sintering process of the milled powders was further studied. Experimental results showed that the density, hardness and transverse rupture strength of the sintered alloys reached 14.224 g/cm3, HRA 94 and 1660 MPa, respectively, by a appropriate coupling of pulse- and subsequent constant-current sintering and with the total sintering time of 6 min. It seemed difficult to obtain desirable sintered hardmetal by a single type of electric current sintering. However, the application of intensive pulse electric current was favorable to sintering, although it was difficult to achieve good WC alloys only by the pulse electric current sintering. A higher density WC alloy could be prepared by enlarging the electric current when only constant electric current was applied to sinter the milled powders. Unfortunately, the WC grains substantially coarsened concurrently so that the mechanical properties of the as sintered alloy decreased obviously.\nJiuhua Xu, Xipeng Xu, Guangqi Cai and Renke Kang\nX. Q. Li et al., \"Fabrication of WC-6Co-1.5Al (wt%) Hardmetal by High Energy Milling and Electrical Current Sintering \", Key Engineering Materials, Vols. 359-360, pp. 409-413, 2008", "domain": "chemistry", "round": 3} +{"url": "http://vyessaycmop.nmmc.info/corona-discharge-thesis.html", "date": "2018-09-23T19:06:14Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-39/segments/1537267159570.46/warc/CC-MAIN-20180923173457-20180923193857-00339.warc.gz", "language_score": 0.756933867931366, "token_count": 772, "dump": "CC-MAIN-2018-39", "global_id": "webtext-fineweb__CC-MAIN-2018-39__0__228088106", "lang": "en", "text": "Corona discharge thesis\nAN ABSTRACT OF THE THESIS OF. Title: Oxidation of Hydrocarbon in a Carbon Nanotube Supported Corona Discharge in Micoreactor: Oxidation of Ethylene. Ionic Reactions in Corona Discharges of Atmospheric Gases. ionic species in a corona discharge in oxygen. This experiment shows several marked. AN ABSTRACT OF THE THESIS OF. Corona discharge is the process by which a current flows from a high electric field gradient area into a neutral fluid. The corona discharge, its properties and specific uses. all discharge forms have. Our electrochemical view of the point-to-plane corona discharge may be. Doctoral Thesis June 2014 Petr Hoffer. Czech Technical University in Prague Faculty of Electrical Engineering Department of Physics. Corona discharge.\nIris Cherry Panorel PULSED CORONA DISCHARGE AS AN ADVANCED OXIDATION PROCESS FOR THE DEGRADATION OF ORGANIC COMPOUNDS IN WATER Acta Universitatis. In the experimental part of this thesis, effect of pulsed corona discharge oxidation in pure water, tap water and humic acids solutions is first evaluated. Partial Discharge Analysis at Arbitrary Voltage Waveform Stimulus XIAOLEI WANG Licentiate Thesis. Corona discharge. Partial Discharge Analysis of Stator Insulation at. Arbitrary Voltage Waveform Stimulus corona discharge at periodic negative step voltage. This Ph.D. thesis.\nCorona discharge thesis\nIONIZATION OF AIR BY CORONA DISCHARGE The members of the Committee approve the master’s thesis of Philip Koshy Panicker Frank K. Lu Supervising Professor _____. AN ABSTRACT OF THE THESIS OF Kevin R. Caple for the degree of Master of Science in Chemical Engineering. a Carbon Nanotube Supported Corona Discharge Microreactor. Western University [email protected] Electronic Thesis and Dissertation Repository August 2011 FEM-FCT Based Dynamic Simulation of Trichel Pulse Corona Discharge in.\nThesis / v. The corona discharge ozone generator is composed of a plastic base box containing corona discharge ceramic electrodes with generation rate of 20-100. Corona discharges: fundamentals and diagnostics E.M. van Veldhuizen The corona discharge and the barrier discharge are both good candidates in these. A STUDY OF PARTIAL DISCHARGE CHARACTERISTICS IN HIGH VOLTAGE INSULATORS A project submitted in partial fulfilment of the requirement for the degree of.\nClick here to see all texts in Ph.D thesis topic.Phd thesis partial discharge - freshsmileclinic.co.ukphd thesis partial discharge. Partial Discharge or Corona. Excerpt from Corona Discharge Because of the. voltage of corona on discharge wires and the. type discharge electrodes. This PhD thesis has been a first. Western University [email protected] Electronic Thesis and Dissertation Repository August 2011 FEM-FCT Based Dynamic Simulation of Trichel Pulse Corona Discharge in.\nDissertation on motivation of employees Phd Thesis Partial Discharge proposal and dissertation help. Partial Discharge or Corona. His PhD Thesis was. Introduction. Corona discharge is a process by which a current flows from an electrode with a high potential into a neutral fluid, usually air, by ionizing that fluid. Institute of chemical technology, prague and institute of plasma physics, as cr water treatment by pulsed streamer corona discharge petr lukeŠ ph.d. thesis. Dissertation on motivation of employees Phd Thesis Partial Discharge proposal and dissertation help. Partial Discharge or Corona. His PhD Thesis was.", "domain": "chemistry", "round": 3} +{"url": "https://www.edocr.com/v/bnnojmnb/globaldocuments/5690012pdfpdf", "date": "2022-01-28T03:42:27Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-05/segments/1642320305341.76/warc/CC-MAIN-20220128013529-20220128043529-00673.warc.gz", "language_score": 0.7079887390136719, "token_count": 455, "dump": "CC-MAIN-2022-05", "global_id": "webtext-fineweb__CC-MAIN-2022-05__0__127705061", "lang": "en", "text": "MATERIAL SAFETY DATA SHEET\nProduct Name: Metronidazole Injection, USP\n1. CHEMICAL PRODUCT AND COMPANY INFORMATION\n275 North Field Drive\nLake Forest, Illinois 60045\nHospira, formerly the Hospital Products Division of Abbott Laboratories, was\ncreated as an independent company in May 2004.\nCHEMTREC: 800 424-9300\nMetronidazole Injection, USP\n2. COMPOSITION/INFORMATION ON INGREDIENTS\n3. HAZARD INFORMATION\nIn clinical use, this material is used to treat bacterial and protozoal infections.\nPossible target organs include the nervous system, reproductive system, liver,\nlungs, and gastrointestinal system.\nInformation on the absorption of this compound via ingestion,\ninhalation or skin contact is not available. Avoid liquid aerosol generation and\nSigns and Symptoms\nNo signs or symptoms from occupational exposure are known. Clinical data\nsuggest the following: seizures, numbness, tingling in the extremities,\nheadaches, anorexia, vomiting, diarrhea, constipation, furry tongue,\nthrombocytopenia, palpitation, dizziness, ataxia, rash, painful urination.\nData suggest any preexisting ailments in the following organs: nervous\nAggravated by Exposure\nsystem, hematopoietic system, liver, gastrointestinal system. Concurrent intake\nof depressants like alcohol. Concurrent use of medications.", "domain": "chemistry", "round": 3} +{"url": "https://www.hrlt.com.au/combustion-tuning-with-overfire-air-case-study.html?page=2", "date": "2021-12-09T08:05:30Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-49/segments/1637964363689.56/warc/CC-MAIN-20211209061259-20211209091259-00332.warc.gz", "language_score": 0.9144873023033142, "token_count": 370, "dump": "CC-MAIN-2021-49", "global_id": "webtext-fineweb__CC-MAIN-2021-49__0__44585186", "lang": "en", "text": "Combustion Tuning with Overfire Air Case Study\nHRL improves black coal fired boiler efficiency resulting in significant cost savings for Australian generator\nAn Australian generator needed assistance with the combustion tuning of one of their black coal fired boilers. The client reported that the boiler had been experiencing operational issues including high concentrations of carbon monoxide and carbon-in-ash, significant splits in the excess oxygen concentrations, economiser erosion, and under performing heat rate.\nHRL worked closely with the client to develop a targeted and cost-effective combustion tuning program; with the primary objective to optimise the unit heat rate. HRL utilised both the mic One online PF distribution and Multipoint Combustion Diagnostic Analysis (MCDA) systems to measure both the relative PF distribution and the resultant combustion gas profile. The combustion tuning program also included the optimisation of the overfire air system; an Australian first for HRL.\nAs a result of the improvements to, and optimisation of, the combustion and OFA systems, this Australian generator has experienced the following benefits:\n- A measurable boiler efficiency improvement, equating to permanent annual fuel savings;\n- Reduction of the excess oxygen setpoint;\n- A reduction of the secondary air flow rate and reduction of associated FD fan power draw;\n- A significant reduction of the flue gas velocity through the economiser; and\n- Reduction of spatial temperature differentials for the secondary superheater and secondary reheater, reducing the risk of overheating.\nHRL estimates that, in general, the total cost savings of combustion tuning could easily exceed $1 million/annum. HRL is working with this client to assess the potential for the combustion tuning of the remaining units, and additional combustion and operational improvements to improve the unit heat rate.", "domain": "chemistry", "round": 3} +{"url": "https://oilchangers.co.nz/services/manual-transmission", "date": "2019-12-05T15:36:10Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-51/segments/1575540481076.11/warc/CC-MAIN-20191205141605-20191205165605-00102.warc.gz", "language_score": 0.8859437108039856, "token_count": 285, "dump": "CC-MAIN-2019-51", "global_id": "webtext-fineweb__CC-MAIN-2019-51__0__55791556", "lang": "en", "text": "Manual Transmission Service - from $49.951\nManual transmission fluid provides lubrication to gears, bearings, shafts, and other internal components. Heat, pressure and friction can slowly break down the additives in the manual transmission fluid. In addition, small particles of metal may come off the gears as they wear and these metal particles can mix with the fluid. Fluids can also become contaminated with water.\nAll of this means your manual transmission fluid needs to be replaced at regular intervals to ensure the fluid remains clean, fresh and can perform it's required job.\nBenefits of the Manual Transmission Service\n- Extends transmission life by providing resistance to oxidation, and sludge formation\n- Reduces risk of premature transmission failure\n- Promotes smooth shifting\n- Reduces wear\nOur technicians will:\n- Evacuate or drain the old manual transmission fluid.\n- Refill with the manufacturer's recommended type and quantity of new fluid2.\nManual transmission repairs and servicing are offered in the following locations:\n- Auckland (Botany Downs & Kingsland)\n- Hamilton (Te Rapa & Killarney Road)\n- Palmerston North\n- Christchurch (Hornby, Riccarton & Papanui)\n1. Synthetic gear oils cost extra.\n2. Price includes up to 2 litres of mineral gear oil. Additional oil will attract an additional charge.", "domain": "chemistry", "round": 3} +{"url": "http://socalautoparts.com/shop/motor-gear-oils/gear-oil-synthetic-lightweight-shockproof-quart/", "date": "2018-09-25T01:18:26Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-39/segments/1537267160853.60/warc/CC-MAIN-20180925004528-20180925024928-00176.warc.gz", "language_score": 0.9207850694656372, "token_count": 473, "dump": "CC-MAIN-2018-39", "global_id": "webtext-fineweb__CC-MAIN-2018-39__0__190592073", "lang": "en", "text": "Unique lubricant with solid microscopic particles offers low drag/high protection. Relatively low viscosity, yet cushions gear teeth under extreme pressure\nHelps to prevent tooth breakage, resists throw-off.\n- Film thickness greater than an SAE 75W140, yet low fluid friction like 80W gear oil or 30W motor oil\n- Excellent low-temp flow, improved cold shifting\n- For racing differentials under moderate loads\nAvoid use with pumps, coolers, and filters as unique medium and affinity for metal can cause clogging. Designed for wet sump transmissions and differentials with splash lubrication.\nRED LINE SYNTHETIC LIGHTWEIGHT SHOCKPROOF GEAR OIL provides unequalled protection for high-performance differentials and transmissions which are heavily loaded or which see shock-loading. This revolutionary lubricant is completely different from conventional lubricant technology in several ways. The viscosity characteristics are significantly improved. Gear teeth need high-viscosity when cold to reduce fluid friction. The ShockProof chemistry significantly reduces the thinning effect of high-temperatures, and can be rated as 75W140 Gear Oil, which provides twice the viscosity in the thin layers between the gear teeth, but has the lower internal fluid friction of a 30 Wt motor oil, which means very little power loss for the protection achieved. ShockProof Gear Oil has a 40% lower coefficient of friction and 250% the load-carrying capacity compared to conventional gear oils, which means that metal-to-metal friction is greatly reduced. Temperature reductions between 25° F – 75° F are common in circle track, road racing, and off-road racing. Improved durability in high-performance use is the primary benefit of the LightWeight ShockProof and along with the improved durability is an improvement in efficiency, but if further improvement in efficiency is desired, and durability is not a major concern SuperLight ShockProof can be used. For maximum durability, use Heavy ShockProof. The cushioning effect of the ShockProof chemistry allows the use of light viscosities in many performance applications with little sacrifice in durability. Red Line ShockProof can be used in conventional, limited-slip, or locker differentials. Red Line ShockProof is designed for use in competition differentials and transmissions.\nSold by Quart", "domain": "chemistry", "round": 3} +{"url": "https://www.mdpi.com/2072-6651/8/3/57", "date": "2018-09-25T11:45:19Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-39/segments/1537267161501.96/warc/CC-MAIN-20180925103454-20180925123854-00425.warc.gz", "language_score": 0.8883612155914307, "token_count": 579, "dump": "CC-MAIN-2018-39", "global_id": "webtext-fineweb__CC-MAIN-2018-39__0__210854739", "lang": "en", "text": "Aflatoxin M1 in Cow’s Milk: Method Validation for Milk Sampled in Northern Italy\nAbstractAflatoxins (AFs) are mycotoxins produced by some species of Aspergillus. In dairy cows, ingested AFB1 is metabolized into carcinogenic AFM1 which is eliminated through milk, thus posing a risk for consumer health. Here we describe the set, validation, and application of screening (ELISA) and confirmatory (HPLC) tests carried out on milk samples collected through official control of mycotoxin levels in northern Italy over a three-year period (2012–2014). The limit of detection (LOD) was set at 5 ppt and 2 ppt for ELISA and HPLC, respectively, and the limit of quantification (LOQ) was 10 ppt for confirmatory HPLC. A total of 1668 milk samples were analyzed: ELISA identified 36 (2.2%) positive milk samples that were subsequently confirmed by HPLC. The level of AFM1 in the positive samples ranged between 18 ± 2 and 208 ± 27 ppt. Of the total samples, only eight (0.5%) were found non-compliant with the EU regulatory limit (50 ppt; range 74 ± 10 to 208 ± 27 ppt). Use of ELISA and HPLC tests in series allows for high-volume analysis of samples, thus saving time and money while guaranteeing high analytical precision and accuracy. View Full-Text\nShare & Cite This Article\nBellio, A.; Bianchi, D.M.; Gramaglia, M.; Loria, A.; Nucera, D.; Gallina, S.; Gili, M.; Decastelli, L. Aflatoxin M1 in Cow’s Milk: Method Validation for Milk Sampled in Northern Italy. Toxins 2016, 8, 57.\nBellio A, Bianchi DM, Gramaglia M, Loria A, Nucera D, Gallina S, Gili M, Decastelli L. Aflatoxin M1 in Cow’s Milk: Method Validation for Milk Sampled in Northern Italy. Toxins. 2016; 8(3):57.Chicago/Turabian Style\nBellio, Alberto; Bianchi, Daniela M.; Gramaglia, Monica; Loria, Andrea; Nucera, Daniele; Gallina, Silvia; Gili, Marilena; Decastelli, Lucia. 2016. \"Aflatoxin M1 in Cow’s Milk: Method Validation for Milk Sampled in Northern Italy.\" Toxins 8, no. 3: 57.\nNote that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.", "domain": "chemistry", "round": 3} +{"url": "https://eprints.ncl.ac.uk/68298", "date": "2023-03-25T01:43:57Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-14/segments/1679296945292.83/warc/CC-MAIN-20230325002113-20230325032113-00216.warc.gz", "language_score": 0.8481848239898682, "token_count": 286, "dump": "CC-MAIN-2023-14", "global_id": "webtext-fineweb__CC-MAIN-2023-14__0__30742474", "lang": "en", "text": "Browse by author\nLookup NU author(s): Professor Geoff Gibson,\nDr Peter Wright,\nProfessor Adrian Mouritz\nFull text for this publication is not currently held within this repository. Alternative links are provided below where available.\nThe changes to the mechanical properties of woven glass laminates with polyester, vinyl esters and phenolic resins during fire exposure are discussed. Unstressed laminates are exposed to a constant one sided heat flux and the residual post-fire strength at room temperature are observed. The modes of loading involving compressive stress are more adversely affected by fire exposures. The analysis shows that integrity times in fire are short and composite structures are more prone to local compressive failure.\nAuthor(s): Gibson AG, Wright PNH, Wu Y-S, Mouritz AP, Mathys Z, Gardiner CP\nPublication type: Article\nPublication status: Published\nJournal: Journal of Composite Materials\nISSN (print): 0021-9983\nISSN (electronic): 1530-793X\nAltmetrics provided by Altmetric", "domain": "chemistry", "round": 3} +{"url": "https://peanutscience.com/article/id/475/", "date": "2023-10-02T14:29:13Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233511000.99/warc/CC-MAIN-20231002132844-20231002162844-00155.warc.gz", "language_score": 0.8308719992637634, "token_count": 294, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__289413779", "lang": "en", "text": "Ammonium bicarbonate was evaluated for efficacy against southern stem rot and Sclerotinia blight of peanut in Georgia and Virginia, respectively. In vitro studies indicated the material provided little inhibition of mycelial growth by Sclerotinia minor and Sclerotium rolfsii, and negligible inhibition of mycelial growth of Rhizoctonia solani AG-4. However, ammonium bicarbonate did effectively inhibit formation of sclerotia by S. rolfsii in vitro. In the field, it was phytotoxic when applied as a granule or as a foliar spray and in general was not effective in controlling disease or increasing pod yield.\nFull Article Available as PDF only - Use Download Feature\nKeywords: Ammonium bicarbonate, Sclerotium rolfsii, Sclerotinia blight, Southern Stem Rot, Sclerotinia minor, PCNB, iprodione\nHow to Cite:\nBrenneman, T. & Csinos, A. & Phipps, P., (1990) “Evaluation of Ammonium Bicarbonate for Control of Soilborne Peanut Pathogens”, Peanut Science 17(1), p.28-31. doi: https://doi.org/10.3146/i0095-3679-17-1-10", "domain": "chemistry", "round": 3} +{"url": "https://www.greenvisionindia.com/product/fta-1000ml/", "date": "2022-12-04T02:57:54Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-49/segments/1669446710953.78/warc/CC-MAIN-20221204004054-20221204034054-00190.warc.gz", "language_score": 0.7930407524108887, "token_count": 355, "dump": "CC-MAIN-2022-49", "global_id": "webtext-fineweb__CC-MAIN-2022-49__0__184214345", "lang": "en", "text": "- Salient Features\n- Method of Use & Dose\nFungal diseases like powdery mildew and botrytis\nFTA is contact and stomach poison. Active ingredients are biodegradable, eco-friendly and safe for nontarget insects like the honeybee and ladybird beetle. FTA controls adult as well as the juvenile stage of a nematode.\nFTA is recommended for all types of plant pathogenic nematodes.\n- FTA controls fungal diseases like powdery mildew Rhizoctonia, Fusarium, Phytophthora, and botrytis\n- FTA works as a contact poison.\n- FTA is safe to humans, the environment and beneficial.\n- FTA doesn’t leave any harmful residual effects on the plant.\n- Organically certified\nFTA is recommended for Powdery mildew Rhizoctonia, Fusarium, phytophthora and Botrytis in agricultural crops.\n- Foliar Spraying:\n- Mix 1 – 2 ml FTA in 1 litre of water and spray on an infected plant.\n- Repeat the application within 5-6 days if the infestation is heavy.\n- Use NanoWet® 0.5 ml/lit for effective control\n- Drenching: make 1 – 2 ml/lit FTA Solution and drench in plant roots\n1 – 2 ml / lit\n- Adjust the pH of the water around neutral\n- Add NanoWet® 0.5ml/lit to improve performance\n- Avoid using under the hot sun. Use in the morning or evening hours.\n- Avoid using alkaline or acidic pH products.", "domain": "chemistry", "round": 3} +{"url": "https://www.sysy.com/product/226017", "date": "2023-06-05T23:42:47Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-23/segments/1685224652184.68/warc/CC-MAIN-20230605221713-20230606011713-00617.warc.gz", "language_score": 0.8156018257141113, "token_count": 835, "dump": "CC-MAIN-2023-23", "global_id": "webtext-fineweb__CC-MAIN-2023-23__0__164307341", "lang": "en", "text": "|Cat. No. 226 017||\n100 µg purified IgG, lyophilized. Albumin and azide were added for stabilization. For reconstitution add 100 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.\nAntibodies should be stored at +4°C when still lyophilized. Do not freeze!\nImmunoprecipitation (IP); Immunoisolation or pulldown of a target molecule using an antibody. For details and product specific hints, please refer to the ”Remarks” section.', $event)\" style=\"cursor: help;\">IP: not tested yet\nImmunocytochemistry (ICC) on 4% PFA fixed cells. Immunoreactivity is usually revealed by fluorescence. Some antibodies require special fixation methods. For details, please refer to the “Remarks” section.', $event)\" style=\"cursor: help;\">ICC: 1 : 500 up to 1 : 1000 gallery\nImmunohistochemistry (IHC) on 4% PFA perfusion fixed tissue with 24h PFA post fixation. Immunoreactivity is usually revealed by fluorescence or a chromogenic substrate. Some antibodies require special fixation methods or antigen retrieval steps. For details, please refer to the ”Remarks” section.', $event)\" style=\"cursor: help;\">IHC: 1 : 1000 up to 1 : 5000 (see remarks) gallery\nImmunohistochemistry (IHC-P) of formalin fixed, paraffin embedded (FFPE) tissue (some antibodies require special antigen retrieval steps, please refer to the ”Remarks” section). Immunoreactivity is usually revealed by fluorescence or a chromogenic substrate.', $event)\" style=\"cursor: help;\">IHC-P: 1 : 100 up to 1 : 200 gallery\nFluorescence-activated cell sorting (FACS); usually cells are fluorescently labeled with antibodies against cell-surface antigens followed by cell-sorter analysis.', $event)\" style=\"cursor: help;\">FACS: yes gallery\n|Subtype||IgG2a (κ light chain)|\n|Immunogen||Synthetic peptide corresponding to residues near the amino terminus of rat c-Fos (UniProt Id: P12841)|\nReacts with: mouse (P01101), rat (P12841), human (P01100).\nOther species not tested yet.\n|Matching control protein/peptide||226-0P|\nIHC: For best results tissue sections should be stored at -20°C in cryoprotectant solution. Prolonged storage at 4°C leads to a substantial loss of signal.\nThe Fos gene family consists of 4 members: c-Fos, FosB, FosL1, and FosL2, also called Fos related antigen 1 and 2 (FRA1 and 2). These leucine zipper proteins can dimerize with proteins of the JUN family leading to the formation of the transcription factor complex AP1 (1).\nThe expression of Fos proteins is rapidly and transiently induced by different extracellular stimuli such as growth factors, cytokines, neurotransmitters, polypeptide hormones, stress (2).\nIn addition Fos proteins can be phosphorylated by ERK kinases modulating transcriptional activity, protein stability and localization (3). c-Fos is the homologue to the Finkel-Biskis-Jinkins (FBJ) murine osteosarcoma virus oncogene (4).", "domain": "chemistry", "round": 3} +{"url": "https://www.dentbear.com/online-dental-store/bonding-agents.html", "date": "2021-08-01T19:32:25Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-31/segments/1627046154219.62/warc/CC-MAIN-20210801190212-20210801220212-00580.warc.gz", "language_score": 0.8413845896720886, "token_count": 1281, "dump": "CC-MAIN-2021-31", "global_id": "webtext-fineweb__CC-MAIN-2021-31__0__72790881", "lang": "en", "text": "View as Grid List\nSun Medical Hybrid Bond Bonding AgentSpecial Price ₹2,650.00 was ₹3,500.00\n- No etching, just one coat\nThe entire bonding procedure takes 35 seconds, start-to-finish.\nChemically-activated Microbrushes® eliminate mixing.\n- Any composite, any curing light\nHalogen, Xenon (Plasma Arc) or even LED.\n- Thin but robust film\nOnly 9 microns but almost no post-op sensitivity.\nThe thin bonding layer results in aesthetic margins and perfect contacts between adjacent teeth. The robust coat blocks both mechanical and chemical stimuli to dentin pulp complex.\n- High bond strength.\n- No etching, just one coat\nGC G Premio BondSpecial Price ₹4,399.00 was ₹4,500.00\n- Low pH (1.5) provides effective and consistent bonding.\n- Use in all total-etch, self-etch and selective etch bonding techniques.\n- Low film thickness (3 microns) enables use with resin cements to bond indirect restorations.\n- Universal (8th generation) bonding agent for use in direct and indirect procedures and treatment of hypersensitivity.\n- Up to 5 minutes working time.\n- Consistent bond strength with easy application.\nIvoclar Vivadent ExciTE F DSC 0.1g Bonding AgentSpecial Price ₹5,590.00 was ₹6,666.00\n- Simple, one-step system due to the patented, initiator-coated applicator brush.\n- No light-curing required if a dual or self-curing composite restorative or luting composite is used.\n- ExciTE F DSC is based on ExciTE F and thus offers the same proven physical properties.\n- Fluoride release.\n- Hygienic Single Dose vessels with applicators in two different sizes: Regular for normal preparations, Small/Endo for micro-cavities and root canals.\nGC Solare Bond Universal self etch 7th Generation Bond Adhesive 5mlSpecial Price ₹3,299.00 was ₹4,455.00\n- Store at room temperature (1-28°C) (33.8-82.4°F)\n- SOLARE UNIVERSAL BOND is flammable. Do not use near open flame. Keep away from sources of ignition. Do not store large quantities in one area. Keep away from direct sunlight.\n- SOLARE UNIVERSAL BOND is volatile. Use in a well ventilated place. Advise patients to breath through nose.\n- In case of contact with eyes, flush immediately with water and seek medical attention.\n- In case of contact with oral tissue or skin, immediately remove with a sponge or cotton pellet. After the restorative treatment is finished, rinse thoroughly with water.\n- If the tissue contacted by the material turns white or forms a blister, advise the patient to leave the affected area undisturbed, until the mark disappears, usually in 1-2 weeks. To avoid contact, it is recommended to apply cocoa butter to the area where rubber dam cannot cover.\n- Avoid inhalation or digestion of material.\n- When spilt on the table or floor, immediately wipe off with a dry cloth.\n- Do not mix with other products.\n- Dispose of all waste according to local regulations.\n- In rare cases the product may cause sensitivity in some people. If any such reactions are experienced, discontinue the use of the product and refer to a physician.\n- Personal protective equipment (PPE) such as gloves, face mask\nSun Medical Super Bond C & B Kit Bonding KitSpecial Price ₹10,999.00 was ₹14,000.00\n- Excellent bond strength to tooth structure (enamel and dentin), metal, porcelain and dental resins.\n- Universal dental applications.\n- Pulpal safety.\n- Formulation of a hybrid layer (resin impregnated layer) in both enamel and dentin. This layer reinforces the tooth surface against recurrent caries and prevents the post-operative hypersensitivity.\n- Super-Bond C&B Quick Monomer is a monomer with curing time faster than Super-Bond C&B Monomer.\nIvoclar Vivadent Excite F 5ml Refill Bonding AgentSpecial Price ₹7,122.00 was ₹9,000.00\n- Convenient and economical dispensing from the VivaPen (approx. 120 applications).\n- Also available in bottles and Soft Touch Single Dose vessels.\n- Reliable adhesion, as ExcitTE F establishes a strong bond to enamel and dentin.\n- Consistent quality due to its acetone-free chemistry.\n- Fluoride release.\n- Reduced postoperative sensitivity because dentin surfaces are effectively sealed.\n- Versatile system – Accurate fit of indirect restorations due to the low film thickness.\nIvoclar Tetric N Bond Universal Bonding Agent 6gmSpecial Price ₹3,499.00 was ₹5,800.00\n- Direct-placed light-curing composite and compomer restorations.\n- Direct-placed core build-ups with light-, self- and dual-curing composites.\n- Repair of fractured composite and compomer restorations.\n- Adhesive cementation of indirect restorations with light- and dual-curing luting composites.\n- Sealing of prepared tooth surfaces before temporary/permanent cementation of indirect resto-rations.\n- Desensitization of hypersensitive cervical areas.\nPrevest Fusion Bond 5 Total Etch Bonding Agent Intro PackSpecial Price ₹675.00 was ₹780.00\n- Adhesion of the composite resin for direct restoration.\n- Simple to use one step bonding material.\n- Excellent adhesion to dentin and enamel.\n- Long lasting bonding strength.", "domain": "chemistry", "round": 3} +{"url": "https://truereligion-jeans.com/qa/question-is-smart-water-a-good-source-of-electrolytes.html", "date": "2021-10-21T17:46:57Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-43/segments/1634323585439.59/warc/CC-MAIN-20211021164535-20211021194535-00142.warc.gz", "language_score": 0.915316641330719, "token_count": 1231, "dump": "CC-MAIN-2021-43", "global_id": "webtext-fineweb__CC-MAIN-2021-43__0__68980453", "lang": "en", "text": "- When should I drink electrolytes?\n- What are the healthiest waters to drink?\n- Can electrolyte water make you sick?\n- Is smart water actually good for you?\n- Why Smart Water is bad for you?\n- What is so special about smart water?\n- What is the fastest way to replenish electrolytes?\n- Does lemon water replace electrolytes?\n- What is the most common electrolyte imbalance?\n- How do you make electrolyte water at home?\n- What is the best drink to replenish electrolytes?\n- Can I drink electrolyte water everyday?\n- Is smart water the same as Gatorade?\n- How many electrolytes should you drink a day?\n- What are symptoms of low electrolytes?\n- Can you drink too much electrolytes?\n- What are the 3 main electrolytes?\nWhen should I drink electrolytes?\nThe best way to keep electrolytes balanced in your body is by paying attention to your thirst.\nJones recommends drinking about two cups of fluid two hours before any physical activity.\nThen, try to drink 4 to 6 ounces every 15 to 20 minutes during physical activity..\nWhat are the healthiest waters to drink?\nThe healthiest type of water is technically hydrogen water because of the potential health benefits of the antioxidants it contains.\nCan electrolyte water make you sick?\nBut just like anything, too many electrolytes can be unhealthy: Too much sodium, formally referred to as hypernatremia, can cause dizziness, vomiting, and diarrhea. Too much potassium, known as hyperkalemia, can impact your kidney function and cause heart arrhythmia, nausea, and an irregular pulse.\nIs smart water actually good for you?\nEnhanced smart water is not as effective working with the body processes as much as the absorption rate through food. Third, while it has been shown that moderate amounts of minerals are found in regular drinking water and are good for you (like calcium) – these are already added to tap water.\nWhy Smart Water is bad for you?\nDepriving the Smart Water ingredients of minerals during the filtration process also leads the water into trying to balance out. … The plastic that goes into making water bottles contain harmful chemicals such as bisphenol A that has links to many health problems, and phthalates that can mimic and disrupt hormones.\nWhat is so special about smart water?\nelectrolytes. smarter water shouldn’t only hydrate, it should taste good, too. electrolytes are ionized minerals such as potassium, calcium, and magnesium, and the unique blend of electrolytes in smartwater creates a taste that is distinctly fresh, crisp and pure.\nWhat is the fastest way to replenish electrolytes?\nNext time you’re in need of an electrolyte boost, try these 5 foods that replenish electrolytes fast.Dairy. Milk and yogurt are excellent sources of the electrolyte calcium. … Bananas. Bananas are known to be the king of all potassium containing fruits and veggies. … Coconut Water. … Watermelon. … Avocado.\nDoes lemon water replace electrolytes?\nAdditionally, you need a combination of other things like magnesium, zinc, sodium, and potassium. These are essentially the main electrolytes your body needs for all cells and organs to function correctly. The problem with only drinking lemon water is that you don’t replace any of these—you only replace lost fluid.\nWhat is the most common electrolyte imbalance?\nHyponatremia, or low sodium, is the most commonly seen type of electrolyte imbalance. Treatment of electrolyte imbalance depends on the specific electrolyte involved and whether the levels are too high or too low.\nHow do you make electrolyte water at home?\nElectrolyte Water1/4 teaspoon salt.1/4 cup lemon juice.1/4 cup lime juice.1 tablespoon honey or agave nectar.1 1/2 cups coconut water.2 cups cold water.\nWhat is the best drink to replenish electrolytes?\n8 Healthy Drinks Rich in ElectrolytesCoconut water. Coconut water, or coconut juice, is the clear liquid found inside of a coconut. … Milk. … Watermelon water (and other fruit juices) … Smoothies. … Electrolyte-infused waters. … Electrolyte tablets. … Sports drinks. … Pedialyte.\nCan I drink electrolyte water everyday?\nWhile it’s unnecessary to drink electrolyte-enhanced beverages all the time, they may be beneficial during prolonged exercise, in hot environments or if you’re ill with vomiting or diarrhea. Sports drinks and other electrolyte waters can be pricey, so you may want to consider a homemade version.\nIs smart water the same as Gatorade?\nGatorade is designed to replace electrolytes lost due to exercise while Smartwater has them added to enhance flavor.\nHow many electrolytes should you drink a day?\nThe suggested intake is 800 mg per day for both males and females. To get a specific measurement of how much to drink we recommend you take a sweat test. How do Nuun Electrolyte enhanced drink-tabs help?\nWhat are symptoms of low electrolytes?\nSymptoms of electrolyte disordersirregular heartbeat.fast heart rate.fatigue.lethargy.convulsions or seizures.nausea.vomiting.diarrhea or constipation.More items…\nCan you drink too much electrolytes?\nMost people, especially those who exercise in hot weather, are more concerned about not drinking enough water. However, drinking too much water can also be dangerous. Overhydration can lead to water intoxication. This occurs when the amount of salt and other electrolytes in your body become too diluted.\nWhat are the 3 main electrolytes?\nThe major electrolytes: sodium, potassium, and chloride.", "domain": "chemistry", "round": 3} +{"url": "https://www.nyp.org/news/researchers-discover-possible-way-beta-amyloid-protein-kills-ner", "date": "2024-03-04T14:56:06Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707947476452.25/warc/CC-MAIN-20240304133241-20240304163241-00611.warc.gz", "language_score": 0.934708833694458, "token_count": 1032, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__58806639", "lang": "en", "text": "Researchers Discover Possible Way Beta-Amyloid Protein Kills Nerve Cells in Brains Affected by Alzheimer's Disease\nInhibitor Is Engineered That Prevents Nerve Cell Death in Laboratory-Grown Cells\nApr 16, 2004\nNew York, NY\nData Suggest Potential Target for Alzheimer's Disease Treatments\nResearchers from Weill Cornell Medical College and Columbia University College of Physicians Surgeons have discovered at least one way in which beta-amyloid, the protein that forms stubborn plaques in the brains of Alzheimer's disease patients, can kill nerve cells.\nNerve cell death is a hallmark of the memory-robbing disorder, and is thought to be the cause of personality changes and other neurological changes that occur with the disease.\nAccording to a report in the April 16 issue of the journal Science, beta-amyloid, a protein long known to accumulate in plaques in the brains of Alzheimer's patients, binds to a protein known as ABAD (beta amyloid-binding alcohol dehydrogenase).\nFinding a way to inhibit this interaction may help prevent nerve cell death, and possibly help prevent the symptoms of Alzheimer's disease, according to the research team led by Dr. Hao Wu, Professor of Biochemistry at Weill Cornell Medical College and Weill Cornell Graduate School of Medical Sciences in New York; Dr. Shirley ShiDu Yan, Associate Professor of Clinical Pathology at Columbia University College of Physicians Surgeons in New York; and Dr. Joyce Lustbader, Senior Research Scientist in Obstetrics and Gynecology at Columbia PS.\nThis interaction between beta-amyloid and ABAD takes place in the mitochondria, which are energy-producing powerhouses inside cells. The study, although preliminary, suggests that this interaction causes the mitochondria to malfunction, triggering apoptosis, or a programmed cell death, that leads to the destruction of nerve cells, the researchers said.\nIn the study, the researchers compared brain tissue from Alzheimer's disease patients to brain tissue from patients the same age who had died of other causes. They found that ABAD and beta-amyloid are bound together tightly in brain tissue from Alzheimer's disease patients, but not in the brain tissue of people without the disease. In additional experiments, they determined the three-dimensional crystal structure of the two components ABAD and beta-amyloid as they bind together.\nThe crystal complex is the first demonstration that beta-amyloid peptide binds to a protein called ABAD and accumulates inside the mitochondria in brain cells, said Dr. Lustbader.\nWe used the crystal structure of the ABAD and beta-amyloid complex to design an inhibitor a short protein known as a peptide that would prevent the two from binding together, said Dr. Wu.\nIn a series of experiments in laboratory-grown nerve cells, the researchers demonstrated that the peptide inhibitor could prevent nerve cell death.\nYou can take normal human nerve cells and treat them in the laboratory with beta-amyloid and the cells will die, essentially. This also happens with cells from transgenic mice that have Alzheimer's disease-like symptoms, said Dr. Wu. But if you pre-treat nerve cells with this inhibitor peptide, they won't die. It appears to protect cells in the laboratory, she said.\nAdditional research in nerve cells suggested that beta-amyloid may change the shape of ABAD, which disrupts its function and leads to the generation of reactive oxygen species, the researchers said. Reactive oxygen species are free radicals, or DNA-damaging reagents that are byproducts of cellular metabolism. Excessive generation of reactive oxygen species can cause nerve cells to malfunction.\nMany researchers believe that Alzheimer's occurs when beta-amyloid clusters in, and ultimately kills, brain cells by causing the production of destructive free radicals in the mitochondria. In experiments in special transgenic mice that produce both ABAD and beta-amyloid, the researchers showed the animals had higher levels of free radicals and more problems with learning and memory than normal mice. This could be what happens in the early stage of Alzheimer's disease when you don't have a lot of deposits but you do have some beta-amyloid, said the researchers. This enzyme-protein complex makes the cells more vulnerable to dying.\nThe next step is to test the peptide directly in transgenic mice with Alzheimer's disease-like symptoms, the researchers said.\nOur findings suggest that one way to treat Alzheimer's would be to develop a drug that prevents the beta-amyloid peptides from binding with ABAD, which might prevent the cascade of damage that Alzheimer's typically leads to, Dr. Yan said. However, more study is needed. Although the peptide inhibited ABAD-beta amyloid interaction in laboratory-grown cells, much more research is necessary to see if it works in the more complex environment inside the brain of a living animal.\nThe study was funded in part by the National Institutes of Health and the Speaker's Fund for Biomedical Research.", "domain": "chemistry", "round": 3} +{"url": "http://www.lithiumprimarybattery.com/china-standard_discharge_current_1_0ma_primary_cell_battery_3_v_cp501932-8279134.html", "date": "2021-11-27T17:20:51Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-49/segments/1637964358208.31/warc/CC-MAIN-20211127163427-20211127193427-00585.warc.gz", "language_score": 0.8336440920829773, "token_count": 760, "dump": "CC-MAIN-2021-49", "global_id": "webtext-fineweb__CC-MAIN-2021-49__0__35407926", "lang": "en", "text": "Payment & Shipping Terms:\n|Max Size(mm):||5.2×20×33||Storing Temperature:||≤30℃|\n|Maximum Scale Surge Current:||300mA||Type:||CP501932|\n|Ambient Humidity In Storage:||≤ 75%RH||Weight:||6g|\nprimary battery cell,\nflat lithium battery\nStandard Discharge Current 1.0mA Primary Cell Battery 3 V CP501932\n|Battery discharged at continuous current 1mA until voltage reaches cut-off voltage 2.0V at ambient temperature 23±2℃|\n|Nominal Voltage||3.0 V|\n|Maximum Continuous Current||200mA|\n|Battery with minimum 50% rated capacity discharged at ambient temperature 23±2℃|\n|Maximum Pulse Discharge Current||300mA|\n|Battery with minimum 50% rated capacity discharged at max pulse for 3 seconds after 27seconds break. Ambient temperature 23±2℃|\nTemperature ≤ 30℃\nHumidity ≤ 75%RH\n|Operating Temperature||-40℃ to +60℃|\n|Battery Dimension||See drawing on pag|\n|Max self-discharged rate at ambient temperature 23±2℃|\n|Shelf Life||10 years|\n|Ambient temperature 23±2℃|\n1. Battery Characteristic\nWe provide the rated voltage is 3.0V\nThe specific energy density of each battery is 300Wh/kg, more than 50% higher than steel shell lithium battery under the condition of the same weight\nWe provide a wide operating temperature range, from -40℃ to +60℃\nThe battery self-discharge less than 2% per year at room temperature\nThere is no voltage passivation problem, also need not activated after long time storage, install-and-play, ultra-high maintenance-free features\nFit for the modern light & handy electronic products\nOverall dimensions can be customized according to different demands, short new product development cycle, fully meeting customers personalized needs\nThe most reliable cell with the best safety performance; able to bear cruel tests without any protection such as short circuit, puncturing, etc.\n2. Main Applications\nWireless telecommunication devices\nLife jacket, signal light, buoy, etc.\nAutomatic meters (water meter, electric meter, gas meter), conventional meters, etc.\n3. Manufacturing Advantages\n4. Company Advantages\n5. FAQS of General Safety Instructions\nThe battery should be kept as dryly as possible when they are in storage.\nThe battery should be stopped to using when the abnormal heat release or leakage occurs.\nThe manual is necessary to read before you would like to use the battery.\nThey will be hot very fast and can lead the gas and other toxic materials leakage if they are closed to fire.\nIf + and - polarity of battery is directly connected, it is called short circuit and it will lead the leakage of gas or materials or a violent rupture.\nIn this case the battery can be damaged by the heat. This can lead short circuit and a toxic material or gas leakage and/or violent rupture.\nThe water explosion will be caused if you throw the batteries into the water.\nContact Person: Angela", "domain": "chemistry", "round": 3} +{"url": "http://www.mdpi.com/2076-2607/5/3/60", "date": "2018-03-19T03:07:36Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-13/segments/1521257646213.26/warc/CC-MAIN-20180319023123-20180319043123-00552.warc.gz", "language_score": 0.8077328205108643, "token_count": 682, "dump": "CC-MAIN-2018-13", "global_id": "webtext-fineweb__CC-MAIN-2018-13__0__190080858", "lang": "en", "text": "Proteomic Characterization of Armillaria mellea Reveals Oxidative Stress Response Mechanisms and Altered Secondary Metabolism Profiles\nAbstractArmillaria mellea is a major plant pathogen. Yet, the strategies the organism uses to infect susceptible species, degrade lignocellulose and other plant material and protect itself against plant defences and its own glycodegradative arsenal are largely unknown. Here, we use a combination of gel and MS-based proteomics to profile A. mellea under conditions of oxidative stress and changes in growth matrix. 2-DE and LC-MS/MS were used to investigate the response of A. mellea to H2O2 and menadione/FeCl3 exposure, respectively. Several proteins were detected with altered abundance in response to H2O2, but not menadione/FeCl3 (i.e., valosin-containing protein), indicating distinct responses to these different forms of oxidative stress. One protein, cobalamin-independent methionine synthase, demonstrated a common response in both conditions, which may be a marker for a more general stress response mechanism. Further changes to the A. mellea proteome were investigated using MS-based proteomics, which identified changes to putative secondary metabolism (SM) enzymes upon growth in agar compared to liquid cultures. Metabolomic analyses revealed distinct profiles, highlighting the effect of growth matrix on SM production. This establishes robust methods by which to utilize comparative proteomics to characterize this important phytopathogen. View Full-Text\n- Supplementary File 1:\nZIP-Document (ZIP, 708 KB)\nScifeed alert for new publicationsNever miss any articles matching your research from any publisher\n- Get alerts for new papers matching your research\n- Find out the new papers from selected authors\n- Updated daily for 49'000+ journals and 6000+ publishers\n- Define your Scifeed now\nCollins, C.; Hurley, R.; Almutlaqah, N.; O’Keeffe, G.; Keane, T.M.; Fitzpatrick, D.A.; Owens, R.A. Proteomic Characterization of Armillaria mellea Reveals Oxidative Stress Response Mechanisms and Altered Secondary Metabolism Profiles. Microorganisms 2017, 5, 60.\nCollins C, Hurley R, Almutlaqah N, O’Keeffe G, Keane TM, Fitzpatrick DA, Owens RA. Proteomic Characterization of Armillaria mellea Reveals Oxidative Stress Response Mechanisms and Altered Secondary Metabolism Profiles. Microorganisms. 2017; 5(3):60.Chicago/Turabian Style\nCollins, Cassandra; Hurley, Rachel; Almutlaqah, Nada; O’Keeffe, Grainne; Keane, Thomas M.; Fitzpatrick, David A.; Owens, Rebecca A. 2017. \"Proteomic Characterization of Armillaria mellea Reveals Oxidative Stress Response Mechanisms and Altered Secondary Metabolism Profiles.\" Microorganisms 5, no. 3: 60.\nNote that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.", "domain": "chemistry", "round": 3} +{"url": "https://encompass.eku.edu/fs_research/488/", "date": "2023-10-03T19:49:44Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233511220.71/warc/CC-MAIN-20231003192425-20231003222425-00594.warc.gz", "language_score": 0.8360785841941833, "token_count": 471, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__113801872", "lang": "en", "text": "Comparison of the ColiPlate Kit with Two Common E. coli Enumeration Methods for Water\nAuthor ORCID Identifier\nJason W. Marion https://orcid.org/0000-0001-5177-889X\nEnvironmental Health Science\nQuantitatively assessing fecal indicator bacteria in drinking water from limited resource settings (e.g., disasters, remote areas) can inform public health strategies for reducing waterborne illnesses. This study aimed to compare two common approaches for quantifying Escherichia coli (E. coli) density in natural water versus the ColiPlate™ kit approach. For comparing methods, 41 field samples from natural water sources in Kentucky (USA) were collected. E. coli densities were then determined by (1) membrane filtration in conjunction with modified membrane-thermotolerant E. coli (mTEC) agar, (2) Idexx Quanti-Tray® 2000 with the Colilert® substrate, and (3) the Bluewater Biosciences ColiPlate kit. Significant correlations were observed between E. coli density data for all three methods (p < 0.001). Paired t-test results showed no difference in E. coli densities determined by all the methods (p > 0.05). Upon assigning modified mTEC as the reference method for determining the World Health Organization-assigned “very high-risk” levels of fecal contamination (> 100 E. coli CFU/100 mL), both ColiPlate and Colilert exhibited excellent discrimination for screening very high-risk levels according to the area under the receiver operating characteristic curve (~89%). These data suggest ColiPlate continues to be an effective monitoring tool for quantifying E. coli density and characterizing fecal contamination risks from water.\nGibson, C.J.; Maritim, A.K.; Marion, J.W. Comparison of the ColiPlate™ Kit with Two Common E. coli Enumeration Methods for Water. Water 2021, 13, 1804. https://doi.org/10.3390/w13131804", "domain": "chemistry", "round": 3} +{"url": "http://origenchubut.gob.ar/carbon-14-dating-unlocking-the-secrets-of-the-past/", "date": "2024-03-03T16:13:10Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707947476396.49/warc/CC-MAIN-20240303142747-20240303172747-00120.warc.gz", "language_score": 0.9370642304420471, "token_count": 1873, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__32015220", "lang": "en", "text": "Have you ever wondered how scientists are able to decide the age of historic artifacts and fossils? Well, one of the wonderful instruments they use is identified as carbon-14 relationship. This fascinating method helps us uncover the mysteries of the past and provides us a glimpse into the lives of our ancestors. In this article, we will explore the ins and outs of carbon-14 dating, the means it works, and why it is so important in the world of archaeology and paleontology.\nWhat is Carbon-14?\nCarbon-14, also referred to as radiocarbon, is a special sort of carbon discovered in the environment. It is produced when cosmic rays from the sun collide with nitrogen atoms. This collision transforms a number of the nitrogen atoms into carbon-14, creating a small but regular quantity of it in the atmosphere.\nHow Does Carbon-14 Dating Work?\nThe precept behind carbon-14 relationship is easy. When an organism is alive, it absorbs carbon from the atmosphere via photosynthesis (if it is a plant) or by consuming other organisms (if it’s an animal). This implies that the organism’s physique incorporates a certain amount of carbon-14.\nHowever, when the organism dies, it not takes in carbon from the ambiance. Over time, the carbon-14 in its body begins to decay. This decay occurs at a predictable price, generally identified as the half-life of carbon-14, which is roughly 5,730 years.\nBy measuring the amount of remaining carbon-14 in a pattern, scientists can determine how long it has been since the organism https://datingscope.net/benaughty-review/ died. This is as a end result of the much less carbon-14 there is, the older the sample is.\nThe Half-Life of Carbon-14\nAs mentioned earlier, the half-life of carbon-14 is approximately 5,730 years. This implies that after 5,730 years, half of the original quantity of carbon-14 in a sample will have decayed. After another 5,730 years, half of the remaining carbon-14 will decay, and so forth.\nUsing this information, scientists can determine the age of a pattern by measuring the ratio of carbon-14 to carbon-12, which is a stable type of carbon that doesn’t decay. By comparing this ratio to the ratio found in residing organisms right now, they can calculate how many half-lives have elapsed and thus determine the age.\nLimitations and Accuracy of Carbon-14 Dating\nWhile carbon-14 dating is a strong tool, it does have its limitations. For occasion, it could possibly only be used to date organic materials, such as bones, wood, and charcoal. It just isn’t effective for dating rocks or inorganic supplies.\nAdditionally, carbon-14 courting turns into much less accurate the older the pattern is. This is as a end result of after a sure point, there’s so little carbon-14 left that it turns into troublesome to measure precisely. Usually, carbon-14 courting is most dependable for samples which might be lower than 50,000 years previous.\nApplications of Carbon-14 Dating\nCarbon-14 courting has revolutionized the sector of archaeology and paleontology. It has supplied archaeologists with a powerful tool for relationship historical artifacts and human stays. By figuring out the age of these artifacts, we are ready to acquire useful insights into the daily lives and cultures of our ancestors.\nFor example, carbon-14 dating has been used to find out the age of the well-known Egyptian pharaohs and the ancient Mayan civilization. It has additionally helped archaeologists understand the migration patterns of early humans and the unfold of agriculture.\nIn the field of paleontology, carbon-14 relationship has been instrumental in understanding the evolution and extinction of assorted species. By courting fossils, scientists can create a timeline of when completely different species lived and how they had been related to one another. This info is crucial for unraveling the mysteries of Earth’s past.\nCarbon-14 relationship is actually a remarkable scientific method that allows us to peer into the past and uncover the hidden stories of our ancestors. Its capacity to accurately determine the age of natural material has transformed the fields of archaeology and paleontology.\nBy measuring the amount of carbon-14 remaining in a pattern, scientists can piece together the puzzle of our history, from the ancient civilizations to the evolution of life on Earth. This software not solely broadens our understanding of the world but in addition ignites our curiosity and sense of marvel about the mysteries that lie buried beneath our ft. So next time you come throughout a fossil or an historic artifact, do not forget that carbon-14 relationship is the vital thing that unlocks the secrets of the past.\n1. What is carbon-14 dating and how does it work?\nCarbon-14 relationship, also referred to as radiocarbon dating, is a method used to discover out the age of natural materials. It depends on the fact that carbon-14, an isotope of carbon, is repeatedly produced within the Earth’s environment by cosmic rays. When an organism dies, it not takes in carbon-14, and the quantity of carbon-14 in its stays progressively decreases via radioactive decay. By measuring the remaining amount of carbon-14 in a pattern, scientists can calculate how lengthy it has been for the reason that organism died.\n2. What are the restrictions of carbon-14 dating?\nCarbon-14 courting has a quantity of limitations. Firstly, it could only be used so far organic materials, similar to bones, wooden, and plant stays. It is not suitable for dating rocks, pottery, or other inorganic materials. Secondly, carbon-14 relationship is only correct as a lot as a certain interval, known as the \"radiocarbon barrier.\" Beyond this point, the amount of carbon-14 left in a sample becomes too small to measure precisely. This barrier is around 50,000 years, making carbon-14 dating unsuitable for very old objects. Lastly, carbon-14 relationship depends on the belief that the ratio of carbon-14 to carbon-12 in the ambiance has remained constant over time, which can not all the time be the case.\n3. Can carbon-14 courting be used to determine the age of fossils?\nYes, carbon-14 dating can be utilized to determine the age of fossilized remains. Fossils are often composed of organic materials, such as bones or enamel, which contain carbon. By analyzing the carbon-14 content material of those remains, scientists can estimate the age of the fossil. However, it’s price noting that for very old fossils, other courting strategies, corresponding to potassium-argon or uranium-lead dating, could also be more appropriate.\n4. How is carbon-14 dating used in archaeological research?\nCarbon-14 relationship is a valuable device in archaeological research. It helps archaeologists decide the age of natural artifacts discovered at archaeological websites, such as picket instruments, bones, and textiles. By relationship these supplies, scientists can set up a chronology and understand the event and interactions of historic civilizations. Carbon-14 courting has allowed archaeologists thus far essential discoveries, such as the Egyptian pyramids, historical cave work, and the stays of historic human ancestors.\n5. What are some of the challenges and uncertainties in carbon-14 dating?\nCarbon-14 dating poses several challenges and uncertainties. One important challenge is contamination. Organic samples could be contaminated with fashionable carbon, making it troublesome to acquire accurate measurements. Additionally, the calibration of carbon-14 relationship could be advanced. The atmospheric carbon-14 ranges have varied over time because of factors similar to solar activity and adjustments within the Earth’s magnetic field. Calibration curves are used to adjust the uncooked carbon-14 dates and provide extra accurate age estimations. However, these curves introduce some level of uncertainty. Despite these challenges, carbon-14 relationship remains a valuable method in figuring out the age of natural supplies.\n6. How is carbon-14 courting utilized in forensic science?\nCarbon-14 relationship could be utilized in forensic science to discover out the age of human stays. By analyzing the carbon-14 ranges in bones or tooth, forensic scientists can estimate the time of demise or the age at which a person died. This information can be essential in felony investigations or identifying human stays in forensic anthropology instances.\n7. Can carbon-14 relationship be used to date objects from historic civilizations, similar to Egyptian mummies?\nYes, carbon-14 dating is often used to date objects from historical civilizations, including Egyptian mummies. These mummies are often preserved in a near-sterile environment, which minimizes contamination. By analyzing the carbon-14 content material of the mother’s remains, scientists can estimate the age of the person. Carbon-14 courting has allowed the identification of mummies from different durations of Egyptian historical past, shedding gentle on their cultural practices, way of life, and historical connections.", "domain": "chemistry", "round": 3} +{"url": "https://www.hindawi.com/journals/amse/2013/976373/ref/", "date": "2017-02-19T23:48:26Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-09/segments/1487501170286.6/warc/CC-MAIN-20170219104610-00458-ip-10-171-10-108.ec2.internal.warc.gz", "language_score": 0.7215142846107483, "token_count": 1820, "dump": "CC-MAIN-2017-09", "global_id": "webtext-fineweb__CC-MAIN-2017-09__0__21072252", "lang": "en", "text": "- About this Journal ·\n- Abstracting and Indexing ·\n- Aims and Scope ·\n- Annual Issues ·\n- Article Processing Charges ·\n- Articles in Press ·\n- Author Guidelines ·\n- Bibliographic Information ·\n- Citations to this Journal ·\n- Contact Information ·\n- Editorial Board ·\n- Editorial Workflow ·\n- Free eTOC Alerts ·\n- Publication Ethics ·\n- Reviewers Acknowledgment ·\n- Submit a Manuscript ·\n- Subscription Information ·\n- Table of Contents\nAdvances in Materials Science and Engineering\nVolume 2013 (2013), Article ID 976373, 8 pages\nImpact Toughness and Ductility Enhancement of Biodegradable Poly(lactic acid)/Poly(ε-caprolactone) Blends via Addition of Glycidyl Methacrylate\n1Chemistry Department, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia\n2Radiation Processing Technology Department, Malaysia Nuclear Agency, Bangi, 43000 Kajang, Selangor, Malaysia\nReceived 9 April 2013; Revised 11 June 2013; Accepted 11 June 2013\nAcademic Editor: Wen-Hua Sun\nCopyright © 2013 Wei Kit Chee et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.\n- M. Kumar, S. Mohanty, S. K. Nayak, and M. Rahail Parvaiz, “Effect of glycidyl methacrylate (GMA) on the thermal, mechanical and morphological property of biodegradable PLA/PBAT blend and its nanocomposites,” Bioresource Technology, vol. 101, no. 21, pp. 8406–8415, 2010.\n- C. L. Simões, J. C. Viana, and A. M. Cunha, “Mechanical properties of poly(ε-caprolactone) and poly(lactic acid) blends,” Journal of Applied Polymer Science, vol. 112, no. 1, pp. 345–352, 2009.\n- O. Martin and L. Avérous, “Poly(lactic acid): plasticization and properties of biodegradable multiphase systems,” Polymer, vol. 42, no. 14, pp. 6209–6219, 2001.\n- L.-T. Lim, R. Auras, and M. Rubino, “Processing technologies for poly(lactic acid),” Progress in Polymer Science (Oxford), vol. 33, no. 8, pp. 820–852, 2008.\n- K. Madhavan Nampoothiri, N. R. Nair, and R. P. John, “An overview of the recent developments in polylactide (PLA) research,” Bioresource Technology, vol. 101, no. 22, pp. 8493–8501, 2010.\n- C.-H. Ho, C.-H. Wang, C.-I. Lin, and Y.-D. Lee, “Synthesis and characterization of TPO-PLA copolymer and its behavior as compatibilizer for PLA/TPO blends,” Polymer, vol. 49, no. 18, pp. 3902–3910, 2008.\n- F. Hassouna, J.-M. Raquez, F. Addiego, P. Dubois, V. Toniazzo, and D. Ruch, “New approach on the development of plasticized polylactide (PLA): grafting of poly(ethylene glycol) (PEG) via reactive extrusion,” European Polymer Journal, vol. 47, no. 11, pp. 2134–2144, 2011.\n- Z. Su, Q. Li, Y. Liu, G.-H. Hu, and C. Wu, “Compatibility and phase structure of binary blends of poly(lactic acid) and glycidyl methacrylate grafted poly(ethylene octane),” European Polymer Journal, vol. 45, no. 8, pp. 2428–2433, 2009.\n- J. W. Park and S. S. Im, “Phase behavior and morphology in blends of poly(L-lactic acid) and poly(butylene succinate),” Journal of Applied Polymer Science, vol. 86, no. 3, pp. 647–655, 2002.\n- M. E. Broz, D. L. VanderHart, and N. R. Washburn, “Structure and mechanical properties of poly(D,L-lactic acid)/poly(ε-caprolactone) blends,” Biomaterials, vol. 24, no. 23, pp. 4181–4190, 2003.\n- L. Jiang, M. P. Wolcott, and J. Zhang, “Study of biodegradable polylactide/poly(butylene adipate-co-terephthalate) blends,” Biomacromolecules, vol. 7, no. 1, pp. 199–207, 2006.\n- N. López-Rodríguez, A. López-Arraiza, E. Meaurio, and J. R. Sarasua, “Crystallization, morphology, and mechanical behavior of polylactide/poly(ε-caprolactone) blends,” Polymer Engineering & Science, vol. 46, no. 9, pp. 1299–1308, 2006.\n- D. Wu, Y. Zhang, L. Yuan, M. Zhang, and W. Zhou, “Viscoelastic interfacial properties of compatibilized poly(ε- caprolactone)/polylactide blend,” Journal of Polymer Science B: Polymer Physics, vol. 48, no. 7, pp. 756–765, 2010.\n- J.-T. Yeh, C.-J. Wu, C.-H. Tsou et al., “Study on the crystallization, miscibility, morphology, properties of poly(lactic acid)/poly(ε-caprolactone) blends,” Polymer—Plastics Technology and Engineering, vol. 48, no. 6, pp. 571–578, 2009.\n- M. Harada, T. Ohya, K. Iida, H. Hayashi, K. Hirano, and H. Fukuda, “Increased impact strength of biodegradable poly(lactic acid)/poly(butylene succinate) blend composites by using isocyanate as a reactive processing agent,” Journal of Applied Polymer Science, vol. 106, no. 3, pp. 1813–1820, 2007.\n- N. Zhang, Q. Wang, J. Ren, and L. Wang, “Preparation and properties of biodegradable poly(lactic acid)/poly(butylene adipate-co-terephthalate) blend with glycidyl methacrylate as reactive processing agent,” Journal of Materials Science, vol. 44, no. 1, pp. 250–256, 2009.\n- T. Xu, Z. Tang, and J. Zhu, “Synthesis of polylactide-graft-glycidyl methacrylate graft copolymer and its application as a coupling agent in polylactide/bamboo flour biocomposites,” Journal of Applied Polymer Science, vol. 125, pp. E622–E627, 2012.\n- H.-T. Liao and C.-S. Wu, “Preparation and characterization of ternary blends composed of polylactide, poly(ε-caprolactone) and starch,” Materials Science and Engineering A, vol. 515, no. 1-2, pp. 207–214, 2009.\n- Y. F. Kim, C. N. Choi, Y. D. Kim, K. Y. Lee, and M. S. Lee, “Compatibilization of immiscible poly(l-lactide) and low density polyethylene blends,” Fibers and Polymers, vol. 5, no. 4, pp. 270–274, 2004.", "domain": "chemistry", "round": 3} +{"url": "http://haenerblock.com/faq/quick-answer-how-to-stop-efflorescence-on-concrete.html", "date": "2023-11-29T01:54:50Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100047.66/warc/CC-MAIN-20231129010302-20231129040302-00718.warc.gz", "language_score": 0.8848047852516174, "token_count": 1238, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__60362098", "lang": "en", "text": "- 1 How do you prevent concrete efflorescence?\n- 2 How do you fix concrete efflorescence?\n- 3 How do you seal efflorescence?\n- 4 Why does efflorescence keep coming back?\n- 5 Does efflorescence go away?\n- 6 Should I worry about efflorescence?\n- 7 Does vinegar remove efflorescence?\n- 8 Can you paint over concrete efflorescence?\n- 9 What is the best efflorescence remover?\n- 10 How do you get rid of stubborn efflorescence?\n- 11 Will Drylok stop efflorescence?\n- 12 Does CLR remove efflorescence?\n- 13 How long does efflorescence last for?\n- 14 Will a dehumidifier help with efflorescence?\n- 15 Is efflorescence a sign of damp?\nHow do you prevent concrete efflorescence?\nQuikrete Acrylic Cure and Seal is an prevention for efflorescence, since it can not only cure concrete and mortar more effectively but also form a sealing topical coating to prevent exterior moisture penetrating into concrete.\nHow do you fix concrete efflorescence?\nA mild solution of muriatic acid has been effectively used for years to remove efflorescence. The solution is usually made with two parts water and one part muriatic acid for a 10% solution.\nHow do you seal efflorescence?\nSimply sealing concrete from water penetration (using a penetrating sealer) will help prevent efflorescence. V-SEAL creates an incredible water barrier for brick, mortar, and all forms of concrete. To help prevent efflorescence, V-SEAL should be sprayed anywhere brick, mortar or cement will be exposed to water.\nWhy does efflorescence keep coming back?\nIf your wall started out with only a small amount of water-soluble salts within it, the efflorescence might stay away on its own after one cleaning, or only lightly return. But if you wall has a high salt content, the efflorescence could develop again and again.\nDoes efflorescence go away?\nIn many cases, efflorescence will disappear on its own over time (usually after the first year of a paver or retaining wall installation). Efflorescence can also be removed with special cleaners like the Gator Efflorescence Cleaner. On average, you should wait about 60 days before applying an efflorescence cleaner.\nShould I worry about efflorescence?\nUltimately, efflorescence itself isn’t dangerous. However, it can lead to potential moisture problems that can cause structural damage to building materials. That means if you notice efflorescence in the basement or on concrete and other structures, it’s important to take action.\nDoes vinegar remove efflorescence?\nVinegar and water solution—Efflorescence can be removed by using a dilute solution of household white vinegar and water. A vinegar and water solution is relatively inexpensive, non-toxic, and easy to obtain, mix and apply.\nCan you paint over concrete efflorescence?\nSOLUTION. If the surface is highly alkaline, wash with a mild solution of H&C Concrete Etching Solution or Muriatic Acid. Painting should be delayed if efflorescence continues.\nWhat is the best efflorescence remover?\nAn acidic cleaner, such as PROSOCO’s Sure Klean Light Duty Concrete Cleaner, can dissolve efflorescence more effectively. Muriatic acid is never recommended for use on masonry and mortar because it can stain or burn your masonry, etch mortar joints and cause premature deterioration through water penetration.\nHow do you get rid of stubborn efflorescence?\nHow to Remove Efflorescence\n- Simple washing can sometimes remove efflorescence. Scrub with a stiff brush and mild detergent or plain water.\n- Power washing also can be effective in removing surface deposits.\n- Sand blasting is effective, but should be used with care.\n- Chemical cleaning might be needed for some cases of efflorescence.\nWill Drylok stop efflorescence?\nEfflorescence should also be treated, but you’ll need more than soap and water to get it off the wall. Since efflorescence is an alkali salt, remove it with liquid or powder DRYLOK® Etch or muriatic acid, paying close attention to usage and safety guidelines.\nDoes CLR remove efflorescence?\nCan You Remove or Clean off Efflorescence? You can remove efflorescence relatively easily with high water pressure (spray) or with acids such as muratic acid. Products such as CLR or Lime-Away can work too if used with water and a brush.\nHow long does efflorescence last for?\nJudging from the feedback received at the Pavingexpert website, most cases of efflorescence become noticeable 3-6 weeks after laying is completed and then last for 3-6 months before gradually disappearing over a period of 3-6 months.\nWill a dehumidifier help with efflorescence?\ncoming to the actual point dehumidifier has nothing to do with efflorescence unless it is caused due to interior humidity. It might – if the efflorescence is due to interior humidity. If the deposits are due to moisture sources other than humidity, then a dehumidifier won’t necessarily reduce the deposits.\nIs efflorescence a sign of damp?\nSome signs of rising damp are easy to point out, like decaying skirting boards or timber, efflorescence on walls, damp patches, mould growth and the peeling and blistering of wallpapers and paints.", "domain": "chemistry", "round": 3} +{"url": "https://www.medkoo.com/products/6218", "date": "2021-10-26T18:32:03Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-43/segments/1634323587915.41/warc/CC-MAIN-20211026165817-20211026195817-00040.warc.gz", "language_score": 0.7377305626869202, "token_count": 1165, "dump": "CC-MAIN-2021-43", "global_id": "webtext-fineweb__CC-MAIN-2021-43__0__108594977", "lang": "en", "text": "WARNING: This product is for research use only, not for human or veterinary use.\nMedKoo CAT#: 406382\nDescription: MPI-0479605 is a potent and selective ATP competitive inhibitor of Mps1. Cells treated with MPI-0479605 undergo aberrant mitosis, resulting in aneuploidy and formation of micronuclei. In cells with wild-type p53, this promotes the induction of a postmitotic checkpoint characterized by the ATM- and RAD3-related-dependent activation of the p53-p21 pathway. In both wild-type and p53 mutant cells lines, there is a growth arrest and inhibition of DNA synthesis. Subsequently, cells undergo mitotic catastrophe and/or an apoptotic response. In xenograft models, MPI-0479605 inhibits tumor growth, suggesting that drugs targeting Mps1 may have utility as novel cancer therapeutics.\nMedKoo Cat#: 406382\nChemical Formula: C22H29N7O\nExact Mass: 407.24336\nMolecular Weight: 407.51\nElemental Analysis: C, 64.84; H, 7.17; N, 24.06; O, 3.93\nSynonym: MPI0479605; MPI 0479605; MPI-0479605.\nIUPAC/Chemical Name: N6-cyclohexyl-N2-(2-methyl-4-morpholinophenyl)-9H-purine-2,6-diamine\nInChi Key: OVJBNYKNHXJGSA-UHFFFAOYSA-N\nInChi Code: InChI=1S/C22H29N7O/c1-15-13-17(29-9-11-30-12-10-29)7-8-18(15)26-22-27-20-19(23-14-24-20)21(28-22)25-16-5-3-2-4-6-16/h7-8,13-14,16H,2-6,9-12H2,1H3,(H3,23,24,25,26,27,28)\nSMILES Code: CC1=CC(N2CCOCC2)=CC=C1NC3=NC(NC4CCCCC4)=C5N=CNC5=N3\nAppearance: Solid powder\nPurity: >98% (or refer to the Certificate of Analysis)\nShipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.\nStorage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).\nSolubility: Soluble in DMSO, not in water\nShelf Life: >2 years if stored properly\nDrug Formulation: This drug may be formulated in DMSO\nStock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).\nHS Tariff Code: 2934.99.9001\nThe following data is based on the product molecular weight 407.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.\n|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|\n|1 mM||1.15 mL||5.76 mL||11.51 mL|\n|5 mM||0.23 mL||1.15 mL||2.3 mL|\n|10 mM||0.12 mL||0.58 mL||1.15 mL|\n|50 mM||0.02 mL||0.12 mL||0.23 mL|\n1: Vijay Kumar D, Hoarau C, Bursavich M, Slattum P, Gerrish D, Yager K, Saunders M, Shenderovich M, Roth BL, McKinnon R, Chan A, Cimbora DM, Bradford C, Reeves L, Patton S, Papac DI, Williams BL, Carlson RO. Lead optimization of purine based orally bioavailable Mps1 (TTK) inhibitors. Bioorg Med Chem Lett. 2012 Jul 1;22(13):4377-85. doi: 10.1016/j.bmcl.2012.04.131. Epub 2012 May 5. PubMed PMID: 22632936.\n2: Tardif KD, Rogers A, Cassiano J, Roth BL, Cimbora DM, McKinnon R, Peterson A, Douce TB, Robinson R, Dorweiler I, Davis T, Hess MA, Ostanin K, Papac DI, Baichwal V, McAlexander I, Willardsen JA, Saunders M, Christophe H, Kumar DV, Wettstein DA, Carlson RO, Williams BL. Characterization of the cellular and antitumor effects of MPI-0479605, a small-molecule inhibitor of the mitotic kinase Mps1. Mol Cancer Ther. 2011 Dec;10(12):2267-75. doi: 10.1158/1535-7163.MCT-11-0453. Epub 2011 Oct 6. PubMed PMID: 21980130.", "domain": "chemistry", "round": 3} +{"url": "https://cipsm.de/publications/research-area-e/anticalign-visualizing-editing-and-analyzing-combined-nucleotide-and-amino-acid-sequence-alignments-for-combinatorial-protein/", "date": "2022-06-25T20:05:42Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-27/segments/1656103036099.6/warc/CC-MAIN-20220625190306-20220625220306-00388.warc.gz", "language_score": 0.9050053358078003, "token_count": 366, "dump": "CC-MAIN-2022-27", "global_id": "webtext-fineweb__CC-MAIN-2022-27__0__10580110", "lang": "en", "text": "ANTICALIgN: visualizing, editing and analyzing combined nucleotide and amino acid sequence alignments for combinatorial protein engineering\nANTICALIgN is an interactive software developed to simultaneously visualize, analyze and modify alignments of DNA and/or protein sequences that arise during combinatorial protein engineering, design and selection. ANTICALIgN combines powerful functions known from currently available sequence analysis tools with unique features for protein engineering, in particular the possibility to display and manipulate nucleotide sequences and their translated amino acid sequences at the same time. ANTICALIgN offers both template-based multiple sequence alignment (MSA), using the unmutated protein as reference, and conventional global alignment, to compare sequences that share an evolutionary relationship. The application of similarity-based clustering algorithms facilitates the identification of duplicates or of conserved sequence features among a set of selected clones. Imported nucleotide sequences from DNA sequence analysis are automatically translated into the corresponding amino acid sequences and displayed, offering numerous options for selecting reading frames, highlighting of sequence features and graphical layout of the MSA. The MSA complexity can be reduced by hiding the conserved nucleotide and/or amino acid residues, thus putting emphasis on the relevant mutated positions. ANTICALIgN is also able to handle suppressed stop codons or even to incorporate non-natural amino acids into a coding sequence. We demonstrate crucial functions of ANTICALIgN in an example of Anticalins selected from a lipocalin random library against the fibronectin extradomain B (ED-B), an established marker of tumor vasculature. Apart from engineered protein scaffolds, ANTICALIgN provides a powerful tool in the area of antibody engineering and for directed enzyme evolution.", "domain": "chemistry", "round": 3} +{"url": "http://walva.org/product-top/65588-mbs-monoclonals/106898-01022584135-hiv-2-p24-capsid-protein-human-immunodeficiency-virus-2-mbs-monoclonals-gen600736-anti-h", "date": "2024-02-22T13:13:31Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707947473819.62/warc/CC-MAIN-20240222125841-20240222155841-00374.warc.gz", "language_score": 0.8529857993125916, "token_count": 599, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__31406781", "lang": "en", "text": "Product short description\nProduct detailed description\nGene name synonims\nOther gene names\nMouse (Mus musculus)\nAlso known as\nHIV-2 p24, Capsid Protein\nSupplied as a liquid in PBS, pH 7.4, 0.1% sodium azide.\nWestern Blot (WB), Immunoprecipitation (IP), Immunofluorescence (IF)\nN/A; Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby.\nSpecificity and cross-reactivity\nRecognizes p24 of HIV-1 and HIV-2. Reactive in IFA of infected cells, immunoprecipitation p24 protein from radiolabeled infected cell extracts.; Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited. This particular antibody might cross react with speacies outside of the listed ones.\nHuman proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.\nStorage and shipping\nStore the antibody at +4 degrees Celsius for short term storage.. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and For optimal long term storage, the antibody should be kept at -20 degrees Celsius. Aliquots are stable for at least 12 months the antibody should be stored at -20 degrees Celsius.. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.\nThe human immunodeficiency virus (HIV) is a lentivirus (a subgroup of retrovirus) that causes HIV infection and over time acquired immunodeficiency syndrome(AIDS). AIDS is a condition in humans in which progressive failure of the immune system allows life-threatening opportunistic infections and cancers to thrive. Without treatment, average survival time after infection with HIV is estimated to be 9 to 11 years, depending on the HIV subtype. Infection with HIV occurs by the transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk. Within these bodily fluids, HIV is present as both free virus particles and virus within infected immune cells. recombinant HIV 1 and 2 gag gene proteins p24, p17, p55 immunodominant epitopes and envelope glycoproteins, gp120 are used for production of diagnostic detection antibodies.", "domain": "chemistry", "round": 3} +{"url": "http://www.jamespinnick.com/download/bioantioxidants", "date": "2019-02-20T21:53:39Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-09/segments/1550247496694.82/warc/CC-MAIN-20190220210649-20190220232649-00627.warc.gz", "language_score": 0.8444061875343323, "token_count": 770, "dump": "CC-MAIN-2019-09", "global_id": "webtext-fineweb__CC-MAIN-2019-09__0__5807759", "lang": "en", "text": "Read Online or Download Bioantioxidants PDF\nSimilar general & reference books\nRight here, all elements of the subject are offered in a compact demeanour. The e-book is obviously dependent, and divided into sections -- uneven synthesis of heterocycles containing just one nitrogen and that of these with a couple of nitrogen as a heteroatom -- such that the required details might be stumbled on at a look.\nThere are numerous mononuclear iron containing enzymes in nature that make the most of molecular oxygen and move one or either oxygen atoms of O2 to substrates. those enzymes catalyze many strategies together with the biosynthesis of hormones, the metabolism of gear, DNA and RNA base fix and, the biosynthesis of antibiotics.\nThe Isoquinoline Alkaloids provides an in-depth evaluation of 22-sub teams of isoquinoline alkaloids all relating to their universal beginning from the amino-acids phenylalanine and tyrosine. The assurance isn't really meant to be complete and encyclopaedic, yet the entire salient beneficial properties of the elucidation of buildings, structural version, stereochemistry, chemical reactions, syntheses, biogenetic origins and relationships, and pharmacology are lined, and an in depth bibliography of unique papers is supplied to aid extra targeted examine.\n- Frontiers in Transition Metal-Containing Polymers\n- Modern power station practice/ 5, Chemistry and metallurgy.\n- Organometallic Photochemistry\nExtra info for Bioantioxidants\nThe \"ideal\" model corresponds to St = oo and is shown as σ^/q = 1 for all τ values. At large τ, the ratio is independent of r, supporting the earlier predictions of Snyder and Adler (1976b). 30 52 Henrik Pedersen and Csaba Horvath 1 Τ CORRELATION OF SNYDER AND ADLER (Nu - IS) ^ (IDEAL MODEL) (aSt)-' Fig. 24. Plot of the asymptotic values of as a function of l/(aSt) calculated by the two-region model [Eqs. (23) and (24)] and by the correlation of Snyder and Adler (1976b). Agreement is observed only for small values of l/(aSt).\n30 by c u r v e s (a) and (b). 017. T h e segmentation and the t u b e coiling act synergistically to effect the radial m a s s transfer in laminar flow t h r o u g h t u b e s . E. Design and O p t i m i z a t i o n In o r d e r to achieve a high sensitivity a n d satisfactory linearity, it is ad vantageous to design e n z y m e r e a c t o r s so that the reaction is diffusion controlled.\nU n d e r conditions such that the transport steps p r o c e e d infinitely fast. A s is c o m m o n in chemical engineering, the intrinsic p a r a m e t e r s and the effec tive rate are then related by introducing an effectiveness factor. F o r ex ample, if w e a s s u m e simple M i c h a e l i s - M e n t e n kinetics, t h e virtual max imum intrinsic rate, V k i n , is given by Vkin = V ^ a x 5 / ( / ^ n . + S) (2) w h e r e Vmax and c o r r e s p o n d to the immobilized e n z y m e and S is the bulk substrate concentration.", "domain": "chemistry", "round": 3} +{"url": "http://www.taipeitimes.com/News/world/archives/2006/11/03/2003334609", "date": "2017-04-24T03:33:30Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-17/segments/1492917118963.4/warc/CC-MAIN-20170423031158-00115-ip-10-145-167-34.ec2.internal.warc.gz", "language_score": 0.9739794731140137, "token_count": 287, "dump": "CC-MAIN-2017-17", "global_id": "webtext-fineweb__CC-MAIN-2017-17__0__276173563", "lang": "en", "text": "Water supplies to 28,000 people in northern China have been cut after an overturned truck spilled 33 tonnes of toxic oil into a river, state media said, in the latest mishap degrading the country's already polluted waterways.\nThe overloaded truck was carrying wash oil, also known as creosote, when it overturned and dumped its contents into a river in Shanxi Province, Xinhua news agency reported on Wednesday.\nThe spill then flowed into the Yangjiapo Reservoir, contaminating 2 million cubic meters of water, the agency said, citing the provincial environmental bureau.\nSupplies to the towns of Dazhai and Sandu in Xiyang County, which the reservoir serves, had been cut, Xinhua said.\nCreosote is commonly used to treat wood products and probably causes cancer in humans, according to the US Agency for Toxic Substances and Disease Registry.\nThe spill occurred last Thursday, Xinhua said, but did not say why it was reported a week later.\nCleanup crews were using pumps, tonnes of activated carbon and other materials to absorb the spill of brown oil, the agency reported.\nTo provide a temporary supply, local authorities were trucking in drinking water to affected residents, and were attempting to connect water pipes to a large well in the nearby village of Mahui, Xinhua said.\nInvestigations showed the truck overturned because of brake failure, the report said.", "domain": "chemistry", "round": 3} +{"url": "http://eawag-bbd.ethz.ch/van/van_map.html", "date": "2021-12-03T04:53:33Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-49/segments/1637964362589.37/warc/CC-MAIN-20211203030522-20211203060522-00073.warc.gz", "language_score": 0.8362483978271484, "token_count": 801, "dump": "CC-MAIN-2021-49", "global_id": "webtext-fineweb__CC-MAIN-2021-49__0__179504099", "lang": "en", "text": "Vanillin, a common flavoring agent, is produced from ground black vanilla bean pods. Vanillin can also be produced from the biodegradation of lignin, a paper manufacturing byproduct and also the second most abundant naturally-occuring biopolymer. Regarding vanilly-alcohol oxidase, Dr. Willem J.H. van Berkel (personal communication, 2001) states, \"Vanillyl alcohol is not a growth substrate for the fungus. The enzyme is only induced by growth on veratryl alcohol, anisyl alcohol and 4-(methoxymethyl)phenol. We have found that the latter compound is the only inducer which is converted by the enzyme.\"\nDemethylation of 4-methoxybenzoate is also included in the pathway. 4-Methoxybenzoate monooxygenase O-demethylates 4-methoxybenzoate in the presence of molecular oxygen and of NAD(P)H as electron donor (Bernhardt et al., 1988). This EAWAG-BBD pathway is arbitrarily chosen as a \"trunk\" pathway, one which funnels the products of other pathways to intermediary metabolism.\nThe following is a text-format Vanillin pathway map. Organisms which can initiate the pathway are given, but other organisms may also carry out later steps. Follow the links for more information on compounds or reactions. This map is also available in graphic (18k) format.\nvanillyl-alcohol oxidase 4-Methoxy- Vanillin <--------------- Vanillyl alcohol benzoate Arthrobacter sp. Ru61a Penicillium simplicissimum Pseudomonas | putida | vanillin | | dehydrogenase | 4-methoxy- | | benzoate | from the | monooxygenase | Toluene, Benzoate v v 2,4-Dichlorobenzoate,---> 4-Hydroxybenzoate Vanillate Bisphenol A and | | | Bisphenol F Pathways | | | | | | 4-hydroxylbenzoate | | | vanillate 1-hydroxylase | | | monooxygenase Hydroquinone <----------+ | | (aerobic) from the | | 4-hydroxybenzoate | or Permethrin | | 3-monooxygenase | vanillate Toluene-4-sulfonate, | | | O-demethylase 4-Carboxy-4'-sulfoazobenzene, | | | (anaerobic) m-Cresol and v +---------------------+ | Dimethyl isopthalate Pathways to the | | | 4-Nitrophenol from the v v | Pathway Phthalate ------> 3,4-Dihydroxybenzoate <------------------------+ Family (Protocatechuate) Pathway | | | | | | +-------------------+ | +-------------------+ | | | procatechuate | | procatechuate | protocatachuate 3,4-dioxygenase | | 4,5-dioxygenase | decarboxylase | | | v v v 3-Carboxy-cis, 2-Hydroxy-4-carboxymuconate Catechol cis-muconate semialdehyde | | | | | | | v v v Intermediary to the to the Metabolism Syringate Nitrobenzene (KEGG) Pathway Pathway\nPage Author(s): Yoav Dori, Dong Jun Oh, Stephen Stephens and Michael TurnbullContact Us\n© 2021, EAWAG. All rights reserved. http://eawag-bbd.ethz.ch/van/van_map.html", "domain": "chemistry", "round": 3} +{"url": "https://port.silverchair.com/biochemsoctrans/search-results?qb=%7B%22Keywords1%22:%22conjugation%22%7D", "date": "2023-12-07T06:40:45Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100650.21/warc/CC-MAIN-20231207054219-20231207084219-00266.warc.gz", "language_score": 0.8483993411064148, "token_count": 383, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__112478397", "lang": "en", "text": "Skip Nav Destination\n1-4 of 4\nBiochem Soc Trans (2021) 49 (5): 2253–2269.\nPublished: 28 October 2021\n... and peptides within nanocarriers has potential to overcome these limitations. This can be achieved by either encapsulating the protein/peptide within the nanoparticle itself or via chemical conjugation to the particle surface [ 17 ]. Moreover, studies have shown that hydrophobic ion pairing is a method...\nBiochem Soc Trans (2020) 48 (1): 123–135.\nPublished: 24 December 2019\n... conjugation, which it still remains as a major issue due to the small number of SUMO E3 ligases discovered so far, in contrast with the large number of SUMO conjugated proteins in the cell. Correspondence: David Reverter ( firstname.lastname@example.org ) 11 10 2019 28 11 2019 4 12 2019 ©...\nBiochem Soc Trans (2009) 37 (1): 88–91.\nPublished: 20 January 2009\n...Dennis W. Grogan HR (homologous recombination) is expected to play important roles in the molecular biology and genetics of archaea, but, so far, few functional properties of archaeal HR have been measured in vivo . In the extreme thermoacidophile Sulfolobus acidocaldarius , a conjugational...\nBiochem Soc Trans (2008) 36 (5): 874–878.\nPublished: 19 September 2008\n... that SUMO (small ubiquitin-related modifier) conjugation/deconjugation equilibrium is affected by various environmental stresses, including osmotic, hypoxic, heat, oxidative and genotoxic stresses. This regulation occurs either at the level of individual targets, through an interplay between stress-induced...", "domain": "chemistry", "round": 3} +{"url": "https://asa2.silverchair.com/anesthesiology/article/93/3/805/38595/Differential-Effects-of-Halothane-and-Thiopental", "date": "2023-11-30T04:13:29Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100164.87/warc/CC-MAIN-20231130031610-20231130061610-00469.warc.gz", "language_score": 0.9327354431152344, "token_count": 4923, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__263682265", "lang": "en", "text": "Pulmonary surfactant is a complex mixture of proteins and phospholipids synthetized by alveolar type II cells. Volatile anesthetics have been shown to reduce surfactant phospholipid biosynthesis by rat alveolar type II cells. Surfactant-associated protein C (SP-C) is critical for the alveolar surfactant functions. Our goal was to evaluate the effects of halothane and thiopental on SP-C messenger RNA (mRNA) expression in vitro in rat alveolar type II cells and in vivo in mechanically ventilated rats.\nIn vitro, freshly isolated alveolar type II cells were exposed to halothane during 4 h (1, 2, 4%) and 8 h (1%), and to thiopental during 4 h (10, 100 micrometer) and 8 h (100 micrometer). In vivo, rats were anesthetized with intraperitoneal thiopental or inhaled 1% halothane and mechanically ventilated for 4 or 8 h. SP-C mRNA expression was evaluated by ribonuclease protection assay.\nIn vitro, 4-h exposure of alveolar type II cells to thiopental 10 and 100 micrometer increased their SP-C mRNA content to 145 and 197%, respectively, of the control values. In alveolar type II cells exposed for 4 h to halothane 1, 2, and 4%, the SP-C mRNA content increased dose-dependently to 160, 235, and 275%, respectively, of the control values. In vivo, in mechanically ventilated rats, 4 h of halothane anesthesia decreased the lung SP-C mRNA content to 53% of the value obtained in control (nonanesthetized, nonventilated) animals; thiopental anesthesia increased to 150% the lung SP-C mRNA content.\nThese findings indicate that halothane and thiopental used at clinically relevant concentrations modulate the pulmonary SP-C mRNA content in rats. In vivo, the additive role of mechanical ventilation is suggested.\nPULMONARY surfactant is a complex mixture of proteins and phospholipids synthetized by alveolar type II (ATII) epithelial cells. It reduces lung alveolar surface tension, maintains alveolar fluid balance, and possibly exhibits host-defense properties. Although the phospholipid makeup of surfactant is critical to its functional integrity, surfactant-associated proteins, particularly the hydrophobic surfactant-associated protein C (SP-C), have been recognized increasingly as conferring the properties of rapid surface adsorption and surface-tension reduction to phospholipids during dynamic compression. 1,2SP-C, which is synthesized exclusively by ATII cells, 3facilitates the adsorption and the spreading of the phospholipids to form the surfactant monolayer 2,4and enhances in vitro the lipid uptake in ATII cells. 5,In vivo , in animal models of surfactant deficiency 6,7and in preterm infants with respiratory distress syndrome, 8bovine-derived exogenous surfactants that contain SP-C are more effective at decreasing the rates of barotrauma and mortality.\nDuring inhalation anesthesia, lung alveolar epithelium is exposed directly to volatile anesthetics. Recently, potentially deleterious effects of halothane on the surfactant metabolism of ATII cells have been described. Our group has shown that halothane at clinically relevant concentrations reduces surfactant phospholipid biosynthesis by rat ATII cells in vitro, 9whereas intravenous anesthetic agents such as thiopental have no effect on phospholipid surfactant metabolism. 10These results highlight differential effects of anesthetic agents on physiologic functions of ATII cells. Whether or not pulmonary SP-C is affected by volatile anesthetics remains to be determined. The present study was designed to assess the effects of halothane and thiopental on surfactant SP-C messenger RNA (mRNA) expression, in vitro in freshly isolated ATII cells and in vivo in mechanically ventilated rats.\nMaterials and Methods\nAnimals were treated according to the guidelines of the French Institut National de la Santé et de la Recherche Médicale (INSERM) for laboratory care of animals.\nAdult male pathogen-free Sprague–Dawley rats (200-220g) (Charles Rivers Breeders, St Aubin les Elbeuf, France) were used within 4 days of delivery. Animals were killed by exsanguination under general anesthesia. Halothane was purchased from Trofield (London, United Kingdom). Sodium thiopental was purchased from Specia (Paris, France). TEMED, ammonium persulfate, and guanidine thiocyanate were from Sigma (La Verpillère, France). [α-32P]UTP (128 × 1011Bq/mmol) was from Amersham (Les Ulis, France). RNAse-free DNAse I and ribonucleases A and T1 were supplied from Boehringer (Mannheim, Germany). Acrylamide–bisacrylamide, phenol, urea, and proteinase K were from Appligene (Illkirch, France). BSU36I restriction enzyme was from New England Biolabs (Beverly, MA). Tissue culture media, supplements, and fetal bovine serum were from Gibco BRL Life Technologies (Cergy Pontoise, France). Tissue culture plastic was from Costar (Cambridge, MA).\nIn Vitro Study\nAlveolar type II cells were isolated from rat lungs by elastase dissociation and purified by differential adherence to plastic as previously described. 9,11Cell isolation yield per rat and cellular viability (assessed by the Trypan blue exclusion test) were 25 ± 1.106and 95 ± 5% (mean ± SD, n = 30). In this preparation, about 60% of the cells are ATII cells. 11For each experiment, freshly isolated cells from four different rats were pooled and immediately plated in 10-cm diameter cell culture plastic dishes (20 × 106cells/dish) with 20 ml of Dulbecco’s modified Eagle’s medium containing 10% fetal bovine serum, 105U/l penicillin, 100 mg/l streptomycin, and 0.25 mg/L amphotericin B; the cells then were exposed to the different experimental conditions (control, halothane, or thiopental). Each experiment was performed three times.\nFreshly isolated ATII cells were exposed to halothane using a 12-l airtight Lwoff chamber (Lequeux, Paris, France) as previously described. 9,12The chamber atmosphere was kept continuously saturated with water at 37°C. In preliminary experiments, we observed that over an 8-h period the different culture conditions used in our experiments did not influence SP-C mRNA expression by ATII cells, the expression being similar in a standard incubator and in the sealed chamber flushed with a 95% air–5% CO2mixture. Halothane was vaporized by directing a 95% air–5% CO2mixture at 5 l/min through a calibrated Fluotec Mark II vaporizer (Abott, Paris, France) placed at the entrance of the chamber. 9Halothane concentration was monitored at the chamber exit port using a halogen monitor (Capnomac Datex, Helsinki, Finland). The effects of halothane on SP-C mRNA expression of ATII cells were assessed during a 4-h exposure with various halothane concentrations (1, 2, and 4%) and during 8-h exposure with 1% halothane.\nExposure of freshly isolated ATII cells to thiopental was achieved by addition of sodium thiopental (molecular weight: 264) to the culture medium (final concentrations: 10 and 100 μm). The cell plates were returned to a standard 95% air–5% CO2 incubator for the desired period of time (4 or 8 h). We chose thiopental concentrations consistent with those that may be observed in plasma in clinical practice. 13,14\nFor each exposure condition, a control point was obtained simultaneously with ATII cells cultured in a standard 95% air–5% CO2incubator without anesthetic exposure. At the end of each experiment, supernatants and adherent cells were frozen immediately in liquid nitrogen and stored at −80°C until RNA extraction.\nIn Vivo Study\nIn all animals (adult rats weighting 200–220 g), anesthesia was induced initially with ether vapor, and then the trachea was cannulated with a 14-gauge catheter. Animals were assigned randomly for maintenance of anesthesia to inhaled 1% halothane or intraperitoneal injection of thiopental. Halothane was vaporized at 1% inspired concentration (one minimal alveolar concentration for rats) 15monitored by a halogen monitor (Capnomac Datex). Rats then were ventilated for 4 and 8 h (n = 6 animals for each duration). Thiopental-anesthetized rats received a first intraperitoneal injection of thiopental (12.5 mg/100 g weight). Three animals ventilated during 8 h needed extra doses of thiopental (3 mg/100 g weight) at the 6th h of ventilation.\nVentilator strategies were identical in all animals and consisted of a fraction of inspired oxygen of 0.21, a tidal volume of 3 ml, and a respiratory rate of 60 breaths/min without positive end-expiratory pressure. A rectal temperature probe was positioned for core temperature monitoring, and temperature was maintained with a heating pad. After 4 or 8 h of ventilation, rats were killed by aorta transsection, and the lungs were removed from the thorax and immediately frozen in liquid nitrogen and stored at −80°C until total pulmonary RNA extraction.\nSix rats anesthetized with ether vapor and immediately killed by section of the abdominal aorta after trachea cannulation without additional anesthesia or mechanical ventilation,were used as a control group.\nRibonuclease Protection Assay\nTotal RNA from lung and cultured ATII cells was isolated using RNAPlus (Bioprobe, Montreuil, France) according to the instructions of the manufacturer. SP-C gene expression by rat ATII cells was evaluated by ribonuclease protection assay on total RNA solubilized in guanidine thiocyanate. 16Total RNA was cohybridized with β-actin and SP-C RNA probes. A 243-nucleotide SP-C riboprobe was obtained from SP-C complementary DNA inserts subcloned into PGEM 4Z phagemid vector. 17Riboprobe synthesis was performed in the presence of [α-32P]UTP (128 × 1011Bq/mmol, 5 × 104Bq) and T7 RNA polymerase after linearization of the vector by BSU36I digestion. The 144-nucleotide β-actin riboprobe was synthesized from a BSU36I rat complementary DNA insert into PGEM 3Z.\nFor hybridization in guanidine thiocyanate, 10 μl of appropriate dilution of RNA preparations was mixed with 2 μl of each labeled riboprobe (105counts/min/μl). After overnight hybridization at room temperature, the samples were treated with ribonucleases A and T1 and exposed to proteinase K. After extraction with phenol:chloroform:isoamylalcohol, the protected RNA:RNA hybrids were precipitated and loaded on a 6% acrylamide–bisacrylamide urea denaturing gel. Quantitative analysis of radioactive protected bands was performed by direct counting of the gel (InstantImager, Packard, Groningen, The Netherlands). To control for variations in RNA loading, the ratio of the SP-C mRNA signal and the corresponding β-actin mRNA signal was calculated for each sample. 16,18Expression of β-actin mRNA has been shown to be constant under various conditions, including halothane and thiopental exposure. 18Relative changes were expressed versus control (nonexposed) cells or control (nonanesthetized, nonventilated) animals.\nResults are presented as the mean ± SD. In vivo results are derived from six animals in each group. For in vitro experiments, cells isolated from four rats were pooled and each experimental datum was accompanied by a control datum derived from the same pool of isolated cells. In vitro results are derived from at least three independent pools of ATII cells. Comparisons between groups were made using a Kruskall–Wallis nonparametric analysis of variance, followed in case of significance by a Mann–Whitney U test. P < 0.05 was accepted as significant.\nIn Vitro Study\nExposure of rat ATII cells to halothane at 1, 2, and 4% for 4 h increased the SP-C:β-actin mRNA ratiocompared with ATII cells cultured in standard conditions for 4 h. The ratio was increased to 160 ± 48%, 232 ± 53%, and 275 ± 110% with 1, 2, and 4% halothane (P < 0.05 for each comparison vs. control value) (fig. 1). The stimulating effect of halothane appeared to be dose-dependent if the SP-C:β-actin mRNA ratio was calculated as a function of halothane concentration using a regression analysis (P = 0.032, r = 0.59, SE of the estimate = 15.35).\nThe culture of ATII cells with thiopental (10 and 100 μm) for 4 h increased theSP-C:β-actin mRNA ratio to 145 ± 48% and 197 ± 97%, respectively, compared with cells cultured in standard conditions (P < 0.05).\nIn some experiments, we evaluated the effects of higher durations of exposure. ATII cells were cultured 4 and 8 h with 1% halothane or 100 μm thiopental (fig. 2). After 4- and 8-h exposure to halothane, the SP-C:β-actin mRNA ratio in ATII cells increased to 160 ± 48% and 121 ± 43%, respectively (P < 0.05). A stronger increase in the SP-C:β-actin mRNA ratio was noted in ATII cells incubated with thiopental for 4 and 8 h (197 ± 97% and 598 ± 359% of the control values;P < 0.05).\nIn Vivo Study\nThe lung SP-C:β-actin mRNA ratio of halothane-anesthetized rats decreased to 47 ± 5% of the control value in animals anesthetized for 4 h (P < 0.05) and to 61 ± 26% in animals anesthetized for 8 h (P < 0.05), compared with (nonventilated, nonanesthetized) control animals (fig. 3). By contrast, in animals anesthetized with intraperitoneal sodium thiopental, the SP-C:β-actin mRNA ratio increased to 150 ± 77% of the control value after 4 h (P < 0.05 ). After 8 h, there was a trend toward an increase of the SP-C:β-actin mRNA ratio (124 ± 33%), which was not statistically significant.\nOur study demonstrates that in vitro , halothane or thiopental used at clinically relevant concentrations and over a short time period increase the SP-C mRNA content in purified rat ATII cells. By contrast, in vivo in mechanically ventilated rats, we observed that inhalation of 1% halothane for 4 h was associated with a marked decrease in the SP-C mRNA content, whereas thiopental anesthesia induced a moderate increase in the SP-C mRNA content.\nBefore the interpretation of these findings, methodologic considerations must be discussed. In the current study, we measured SP-C mRNA content using ribonuclease protection assay. This method of solution hybridization has been shown to be easier than Northern blot and an excellent method to quantify relatively abundant mRNA. 19\nWe exposed freshly isolated ATII cells, which are about 60% pure, to anesthetic agents. Because expression of SP-C is specific to ATII cells, 3this probably did not influence our results, particularly if halothane or thiopental did not influence the release of factors from these others cells that could have affected the SP-C metabolism. In vitro experiments allowed us to approach the in vivo conditions of alveolar epithelial cells exposure to inhaled anesthetics. This model has been validated by previous studies by our group. 9,10,12Similarly, ATII cells were exposed to thiopental concentrations consistent with those measured in plasma during anesthesia after thiopental administration. 13,14These concentrations, however, are probably higher than the actual free thiopental concentrations. Moreover, thiopental concentrations in alveolar space during anesthesia are unknown.\nIn vivo , we studied anesthetized and mechanically ventilated rats. We used ether vapor to perform tracheotomy in rats. The effects of ether on surfactant metabolism in vivo have not been studied. All animals, however, were exposed in similar manners to ether vapor. We believe that our in vivo experimental model reproduces some of the usual circumstances of anesthesia in humans. One percent inspired concentration of halothane has been shown to be the minimum alveolar concentration for rats. 15\nIn our study, thiopental induced a significant increase in SP-C mRNA content in both the in vivo and the in vitro experiments. The effects of thiopental on surfactant have not been studied extensively. Ward and Nicholas 20have shown in vivo in rats that thiopental anesthesia inhibits surfactant phospholipid release in the alveolar compartment, leading to an increase in surfactant synthesis. Marota et al. 18have observed that thiopental in vivo in rats increases the cerebral content of jun-B mRNA after 120 min of anesthesia. In that study, thiopental did not modify the cerebral β-actin mRNA content. In vitro , thiopental administration is associated with a significant increase in mRNA synthesis in hepatocytes. 21Phenobarbital also has been shown to increase in vivo the hepatic α1-acid glycoprotein mRNA content. This effect was related to a transcriptional regulation of the gene through a specific phenobarbital responsive element. 22We speculate that thiopental can increase SP-C mRNA expression through a transcriptional regulation. The variation in SP-C protein lung content induced by the variation in SP-C mRNA content, however, remains undetermined.\nIn vitro , we observed that halothane increased the SP-C mRNA content of ATII cells. Only a few studies have previously reported the effects of halothane on specific mRNA expression. Inhibition of RNA transcription in lymphocytes exposed to halothane for 6 hours has been described in vitro . 23,In vivo, halothane anesthesia in rats decreases the cerebral jun-B mRNA content, 18whereas c-fos mRNA content is unchanged and decreases the lung macrophage inflammatory protein-2 mRNA content after an inflammatory challenge. 24These results highlight a differential effect of halothane on the expression of various mRNAs that could be related to transcriptional or posttranscriptional changes. To our knowledge, however, precise mechanisms of action of halothane have not been elucidated. Surprisingly, we observed opposite findings between in vivo and in vitro expression of SP-C mRNA exposed to halothane. Halothane produced a significant decrease in lung SP-C mRNA content in mechanically ventilated rats, whereas in vitro halothane exposure of ATII cells increased the SP-C mRNA content. Results from in vivo experiments reflect effects of both anesthetic agent and mechanical ventilation. Our in vivo experimental model does not allow us to differentiate these two effects clearly. Experimental models designed to ventilate mechanically animals without anesthesia are not available. In preliminary experiments, we observed that spontaneously breathing rats anesthetized with halothane and thiopental died within 2 hours because of alveolar hypoventilation and major lung atelectasis. Experimental models of perfused and ventilated isolated lungs could have been useful to individualize the effects of mechanical ventilation on SP-C. These models, however, do not allow for ventilation of the lungs for 4 or 8 hours. Data on effects of mechanical ventilation on surfactant are scarce. Wirtz and Dobbs 25have shown that the mechanical stretch of ATII cells increases the cytosolic calcium concentration and stimulates the secretion of surfactant phospholipid. In a similar model, Gutierrez et al. 26have demonstrated that mechanical distension of ATII cells resulted in a 20% decrease in the mRNA content of SP-C and a 35% decrease of the surfactant-associated protein B mRNA content. The decrease appeared related to changes at both transcriptional and posttranscriptional levels. These data suggest that mechanical distension induced by mechanical ventilation can reduce the SP-C mRNA content in ATII cells. This effect could explain why halothane induced a mild increase in the SP-C mRNA in vitro whereas SP-C mRNA content decreased during halothane anesthesia in mechanically ventilated rats. It also could explain why the increase in the lung SP-C mRNA content after thiopental anesthesia was much less important than the increase observed after in vitro exposure of ATII cells to thiopental. Behavior of isolated cultured ATII cells are likely to be different from in vivo cells because of loss of cellular interactions in vitro . These changes also could account for the discrepancy in results between our two experimental conditions.\nThe results of this study shows that mechanical ventilation under halothane anesthesia decreases the SP-C mRNA pulmonary content in rats, but thiopental anesthesia in the same conditions increases the SP-C mRNA content. Ventilation-induced injury such as alveolar edema has been recognized recently as one of the potential complications of mechanical ventilation. Surfactant inactivation has been suggested to be one component of various events occurring during ventilation-induced lung injury. 27Moreover, halothane can alter phosphatidyl secretion in ATII cells. 9Taken together, these experimental findings suggest potentially additive deleterious effects of volatile anesthetics and mechanical ventilation on the homeostasis of the alveolar space. This might be particularly relevant in patients with acute lung injury. In these particular clinical conditions, surfactant metabolism is already impaired. 28,29It remains to be determined whether the variations in SP-C mRNA content induced by anesthetics translate into similar variations in SP-C protein.\nOur results suggest a positive effect of halothane and thiopental on the pulmonary SP-C mRNA content in rats ATII cells in vitro. By contrast, in vivo during anesthesia and mechanical ventilation, thiopental and halothane have different effects. Further studies are needed to address the clinical significance of these effects.\nThe authors thank Dr B. Escoubet, INSERM Unité 416, Faculté Bichat, Paris, for the gift of β-actin probe, and Dr. J. B. Fisher, Department of Medicine, University of Colorado, Denver, Colorado, for the gift of SP-C probe.", "domain": "chemistry", "round": 3} +{"url": "http://leti.spmayskoe.ru/radioactive-carbon-dating-is-useful-for-the-past-27.html", "date": "2018-11-16T04:28:16Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-47/segments/1542039742970.12/warc/CC-MAIN-20181116025123-20181116050237-00016.warc.gz", "language_score": 0.9361225962638855, "token_count": 618, "dump": "CC-MAIN-2018-47", "global_id": "webtext-fineweb__CC-MAIN-2018-47__0__16937713", "lang": "en", "text": "Radioactive carbon dating is useful for the past dating abu garcia ambassadeur\nOther radiometric dating methods such as potassium-argon or rubidium-strontium are used for such purposes by those who believe that the earth is billions of years old.\nRadiocarbon is not suitable for this purpose because it is only applicable: a) on a time scale of thousands of years and b) to remains of once-living organisms (with minor exceptions, from which rocks are excluded).\nDesmond Clark (1979) wrote that were it not for radiocarbon dating, \"we would still be foundering in a sea of imprecisions sometime bred of inspired guesswork but more often of imaginative speculation\" (Clark, 1979:7).\nWriting of the European Upper Palaeolithic, Movius (1960) concluded that \"time alone is the lens that can throw it into focus\".\nIn the following article, some of the most common misunderstandings regarding radiocarbon dating are addressed, and corrective, up-to-date scientific creationist thought is provided where appropriate. Radiocarbon is used to date the age of rocks, which enables scientists to date the age of the earth.\nRadiocarbon is not used to date the age of rocks or to determine the age of the earth.\nWhen they strike ordinary atoms in the upper atmosphere, the cosmic rays smash them apart. Some of these neutrons then collide with nitrogen atoms.\nRb)—are not being formed on earth, as far as we know.\n\"Everything which has come down to us from heathendom is wrapped in a thick fog; it belongs to a space of time we cannot measure.\nWe know that it is older than Christendom, but whether by a couple of years or a couple of centuries, or even by more than a millenium, we can do no more than guess.\" [Rasmus Nyerup, (Danish antiquarian), 1802 (in Trigger, 19)].\nMany people assume that rocks are dated at “millions of years” based on radiocarbon (carbon-14) dating. The most well-known of all the radiometric dating methods is radiocarbon dating.\nCarbon-14 can yield dates of only “thousands of years” before it all breaks down.\nSearch for radioactive carbon dating is useful for the past:\nAnd as far as we know, it has been forming in the earth’s upper atmosphere since the atmosphere was made back on Day Two of Creation Week (part of the expanse, or firmament, described in Genesis 1:6–8). Cosmic rays from outer space are continually bombarding the upper atmosphere of the earth, producing fast-moving neutrons (subatomic particles carrying no electric charge) (Figure 1a).1 These fast-moving neutrons collide with atoms of nitrogen-14, the most abundant element in the upper atmosphere, converting them into radiocarbon (carbon-14) atoms.", "domain": "chemistry", "round": 3} +{"url": "https://www.babraham.ac.uk/seminars/2024/01/babraham-distinguished-seminar-lipid-switches-cell-physiology-nutrient-signals", "date": "2024-02-21T07:38:14Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707947473401.5/warc/CC-MAIN-20240221070402-20240221100402-00188.warc.gz", "language_score": 0.8571251630783081, "token_count": 987, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__141548834", "lang": "en", "text": "The Babraham Distinguished Seminar Series is sponsored by the Babraham Institute and the Babraham Research Campus which is home to more than 50 biotech companies. The seminars are also advertised to the wider Cambridge community. The series will provide exciting science talks by distinguished scientists from across the world in many areas of biomedical interest.\nProfessor Volker Haucke; Leibniz Forschungsinstitut für Molekulare Pharmakologie (FMP)\nFollowing his PhD in biochemistry from the Biozentrum of the University of Basel and postdoctoral work at Yale University School of Medicine Volker Haucke established his own laboratory at the University of Göttingen. He was appointed as a full professor of biochemistry at the Freie Universiät Berlin in 2003. Since 2012 he is director at the Leibniz Forschungsinstitut für Molekulare Pharmakologie (FMP), professor of molecular pharmacology at Freie Universität Berlin and a member of the NeuroCure Cluster of Excellence. The focus of research in his laboratory is the dissection of the molecular mechanisms of endocytosis and endolysosomal membrane dynamics with a focus on the role of signaling lipids. The laboratory uses a wide range of technologies that include biochemical and cell biological approaches, electrophysiology, chemical biology, super-resolution and electron microscopy as well as genetic manipulations at the organismic level in vivo. His discoveries have provided insight into the roles of lipids in cell physiology and open new avenues for the treatment of human diseases ranging from cancer and thrombosis to neurological disorders.\nPhosphoinositides (PIs) form a minor class of phospholipids with crucial functions in cell physiology, ranging from cell signalling and motility to a role as signposts of compartmental membrane identity and dynamics. In fed cells, phosphatidylinositol 3-phosphates are present at the plasma membrane and within the endosomal system, where they serve as key regulators of both cell signaling and of intracellular membrane dynamics, while PI 4-phosphates delineate the secretory pathway. In my talk I will discuss the localization, regulation, and molecular mechanism of action of PI kinases and phosphatases and their roles in endocytosis and within the endolysosomal system. Moreover, I will cover our recent advances in the analysis of the metabolic pathways that regulate the cellular synthesis and turnover of distinct PI phosphates at endosomes or lysosomes in response to altering nutrient conditions, discuss the mechanisms by which these lipids regulate endolysosomal membrane dynamics and metabolism, and provide examples of how dysregulation of these pathways may cause human disease. Our data provide a framework for how PI phosphate metabolism is integrated into the cellular network and identify PI kinases as targets for future therapeutics. References (1) Ebner, M. et al, Haucke, V. (2023) Nutrient regulated control of lysosome function by signaling lipid conversion. Cell 186, 5328-5346. doi: 10.1016/j.cell.2023.09.027 (2) Lo, W.T. et al, Haucke, V. (2023) Development of selective inhibitors of phosphatidylinositol 3-kinase C2α. Nat Chem Biol 19, 18-27. doi: 10.1038/s41589-022- 01118 (3) Jang, W. et al, Haucke, V. (2022) Endosomal lipid signalling reshapes the endoplasmic reticulum to control mitochondrial function. Science 378, eabq5209. DOI: 10.1126/science.abq5209 (4) Posor, Y.*, Jang, W.*, Haucke, V. (2022) Phosphoinositides as membrane organizers. Nat Rev Mol Cell Biol 23, 797-816. doi: 10.1038/s41580-022-00490-x (5) Lo, W.T. et al, Haucke, V. (2022) Structural basis of PI3KC2a function. Nat Struct Mol Biol. 29, 218- 228; doi: 10.1038/s41594-022-00730-w (6) Marat, A.L. et al, Haucke, V. (2017) mTORC1 activity repression by late endosomal phosphatidylinositol 3,4-bisphosphate. Science 356, 968-972.\nIn order to attend this seminar registration is required\nEvent Time & Dates", "domain": "chemistry", "round": 3} +{"url": "http://csreduhub.com/library/asymmetric-organocatalysis", "date": "2021-01-27T22:15:53Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-04/segments/1610704833804.93/warc/CC-MAIN-20210127214413-20210128004413-00272.warc.gz", "language_score": 0.750319242477417, "token_count": 472, "dump": "CC-MAIN-2021-04", "global_id": "webtext-fineweb__CC-MAIN-2021-04__0__30149036", "lang": "en", "text": "By Daniela Kampen, Corinna M. Reisinger, Benjamin List (auth.), Benjamin List (eds.)\nKerstin Etzenbach-Effers, Albrecht Berkessel: Non-Covalent Organocatalysis in accordance with Hydrogen Bonding: Elucidation of response Paths via Computational Methods.- Petri M. Pihko, Inkeri Majander, and Anniina Erkkilä: Enamine Catalysis.- Jennifer L. Moore, Tomislav Rovis: Lewis Base Catalysts 6: Carbene Catalysts.- Amal Ting, Jennifer M. Goss, Nolan T. McDougal, and Scott E. Schaus: Brønsted Base Catalysts.- O. Andrea Wong, Yian Shi: Chiral Ketone and Iminium Catalysts for Olefin Epoxidation.- Alan C. Spivey, Stellios Arseniyadis: Amine, Alcohol and Phosphine Catalysts for Acyl move Reactions.- John B. Brazier, Nicholas C.O. Tomkinson: Lewis Base Catalysts 2 Secondary and first Amine Catalysts for Iminium Catalysis.- Oksana Sereda, Sobia Tabassum, and René Wilhelm: Lewis Acid Organocatalysts.- Daniela Kampen , Corinna M. Reisinger , and Benjamin checklist: Chiral Bronsted Acids for C Organocatalysis.-\nRead Online or Download Asymmetric Organocatalysis PDF\nSimilar Chemistry books\nA primary knowing of polymers has developed in recent times concurrent with advances in analytical instrumentation. The theories and methodologies built for the galacturonan biopolymers (collectively referred to as pectins) have seldom been discoursed comprehensively within the context of the hot wisdom.\nThis monograph sequence is commissioned by means of the Phytochemical Society of North the USA (PSNA). The volumes during this sequence comprise articles on constructing themes of curiosity to scientists, scholars and participants drawn to contemporary advancements within the biochemistry, chemistry and molecular biology of vegetation.\nEbook by way of Plimmer, Jack R.\nAdditional info for Asymmetric Organocatalysis", "domain": "chemistry", "round": 3} +{"url": "http://agro.icm.edu.pl/agro/element/bwmeta1.element.agro-article-74e4ff63-b178-43a7-8e4f-8335de7215dd", "date": "2020-09-22T15:45:08Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-40/segments/1600400206133.46/warc/CC-MAIN-20200922125920-20200922155920-00363.warc.gz", "language_score": 0.6661913394927979, "token_count": 3047, "dump": "CC-MAIN-2020-40", "global_id": "webtext-fineweb__CC-MAIN-2020-40__0__167642578", "lang": "en", "text": "Dynamics of estrogen-induced oxidative stress\nTreść / Zawartość\nThe objective of this study was to assess the dynamics of oxidative damage to cellular macromolecules such as proteins, lipids and DNA under conditions of oxidative stress triggering early stages of estrogen-dependent carcinogenesis. A rodent model of carcinogenesis was used. Syrian hamsters were sacrificed after 1, 3, 5 h and one month from the initial implantation of estradiol. Matching control groups were used. Kidneys as target organs for estradiol-mediated oxidative stress were excised and homogenized for biochemical assays. Subcellular fractions were isolated. Carbonyl groups (as a marker of protein oxidation) and lipid hydroxyperoxides were assessed. DNA was isolated and 8-oxodGuo was assessed. Electron paramagnetic resonance spectroscopy was used to confirm the results for lipid peroxidation. Exposition to estradiol in the rodent model leads to damage of macromolecules of the cell, including proteins and DNA, but not lipids. Proteins appear to be the primary target of the damage but are closely followed by DNA. It has previously been speculated that protein peroxides can increase DNA modifications. This time sequence was observed in our study. Nevertheless, the direct relation between protein and DNA damage still remains unsolved.\n- Medical University of Gdansk, Debinki 1, 80-211 Gdansk, Poland\n- Aggarwal BB, Ichikawa H (2005) Molecular targets and anticancer potential of indole-3-carbinol and its derivatives. Cell Cycle 4: 1201–1215.\n- American Cancer Society (2001) Cancer Facts and Figs. American Cancer Society, Atlanta, Georgia.\n- Bellomo G, Vairetti M, Stivala L, Mirabelli F, Richelmi P, Orrenius S (1992) Demonstration of nuclear compartmentalization of glutathione in hepatocytes. Proc Natl Acad Sci USA 89: 4412–4416.\n- Bowcock A (1999) Breast Cancer. Humana Press, Clifton, NJ.\n- Chen Y, Liu X, Pisha E, Constantinou AI, Hua Y, Shen L, van Breemen RB, Elguindi EC, Blond SY, Zhang F, Bolton JL (2000) A metabolite of equine estrogens, 4-hydroxyequilenin, induces DNA damage and apoptosis in breast cancer cell lines. Chem Res Toxicol 13: 342–350.\n- Chen Y, Shen L, Zhang F, Lau SS, van Breemen RB, Nikolic D, Bolton JL (1998) The equine estrogen metabolite 4-hydroxyequilenin causes DNA single-strand breaks and oxidation of DNA bases in vitro. Chem Res Toxicol 11: 1105–1111.\n- Cooke MS, Olinski R, Evans MD (2006) Does measurement of oxidative damage to DNA have clinical significance? Clin Chim Acta 365: 30–49.\n- Du J, Gebicki JM (2002) DNA degradation and protein peroxidation in cells exposed to hydroxyl free radicals. Redox Rep 7: 329–331.\n- Foksinski M, Bialkowski K, Skiba M, Ponikowska I, Szmurlo W, Olinski R (1999) Evaluation of 8–oxodeoxyguanosine, typical oxidative DNA damage, in lymphocytes of ozone-treated arteriosclerotic patients. Mutat Res 438: 23–27.\n- Friedberg EC, Walker GC, Siede W (1995) DNA Repair and Mutagenesis. American Society for Microbiology, Washington, DC.\n- Gackowski D, Kruszewski M, Bartlomiejczyk T, Jawien A, Ciecierski M, Olinski R (2002) The level of 8–oxo-7,8–dihydro-2’-deoxyguanosine is positively correlated with the size of the labile iron pool in human lymphocytes. J Biol Inorg Chem 7: 548–550.\n- Gautier JC, Holzhaeuser D, Markovic J, Gremaud E, Schilter B, Turesky RJ (2001) Oxidative damage and stress response from ochratoxin a exposure in rats. Free Radic Biol Med 30: 1089–1098.\n- Gebicki S, Gebicki JM (1999) Crosslinking of DNA and proteins induced by protein hydroperoxides. Biochem J 338: 629–636.\n- Hashimoto R, Narita S, Yamada Y, Tanaka K, Kojo S (2000) Unusually high reactivity of apolipoprotein B-100 among proteins to radical reactions induced in human plasma. Biochim Biophys Acta 1483: 236–240.\n- Hayes CL, Spink DC, Spink BC, Cao JQ, Walker NJ, Sutter TR (1996) 17α-Estradiol hydroxylation catalyzed by human cytochrome P450 1B1. Proc Natl Acad Sci USA 93: 9776–9781.\n- Jefcoate CR, Liehr JG, Santen RJ, Sutter TR, Yager JD, Yue W, Santner SJ, Tekmal R, Demers L, Pauley R, Naftolin F, Mor G, Berstein L (2000) Tissue-specific synthesis and oxidative metabolism of estrogens. J Natl Cancer Inst Monogr 27: 95–112.\n- Kim JG, Sabbagh F, Santanam N, Wilcox JN, Medford RM, Parthasarathy S (1997) Generation of a polyclonal antibody against lipid peroxide-modified proteins. Free Radic Biol Med 23: 251–259.\n- Krajowy Rejestr Nowotworów Centrum Onkologii-Instytut im. M. Skłodowskiej-Curie (2003) Nowotwory złośliwe w Polsce w 2000 roku. Warszawa (in Polish).\n- Kobiela J, Krajewski J, Kalinska-Blach B, Stefaniak T (2002) Selectivity of oxidative stress targeting in estrogen-induced experimental nephrocarcinogenesis. Acta Biochim Polon 49: 51–58.\n- Lebovitz RM, Zhang H, Vogel H, Cartwright J Jr, Dionne L, Lu N, Huang S, Matzuk MM (1996) Neurodegeneration, myocardial injury, and perinatal death in mitochondrial superoxide dismutase-deficient mice. Proc Natl Acad Sci USA 93: 9782–9787.\n- Li Y, Huang TT, Carlson EJ, Melov S, Ursell PC, Olson JL, Noble LJ, Yoshimura MP, Berger C, Chan PH, Wallace DC, Epstein CJ (1995) Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase, Nat Genet 11: 376–381.\n- Luxford C, Morin B, Dean RT, Davies MJ (1999) Histone H1- and other protein- and amino acid-hydroperoxides can give rise to free radicals which oxidize DNA. Biochem J 344: 125–134.\n- Malins DC, Haimanot R (1991) Major alterations in the nucleotide structure of DNA in cancer of the female breast. Cancer Res 51: 5430–5432.\n- Malins DC, Holmes EH, Polisssar NL, Gunselman SJ (1993) The etiology of breast cancer. Characteristic alterations in hydroxyl radical-induced DNA base lesions during oncogenesis with potential for evaluating incidence risk. Cancer 17: 3036–3043.\n- Matsui A, Ikeda T, Enomoto K, Hosoda K, Nakashima H, Omae K, Watanabe M, Hibi T, Kitajima M (2000) Increased formation of oxidative DNA damage, 8-hydroxy-2’-deoxyguanosine, in human breast cancer tissue and its relationship to GSTP1 and COMT genotypes. Cancer Lett 151: 87–95.\n- Mobley JA, Brueggemeier RW (2002) Increasing the DNA damage threshold in breast cancer cells. Toxicol Appl Pharmacol 180: 219–226.\n- Molinari AM, Bontempo P, Schiavone EM, Tortora V, Verdicchio MA, Napolitano M, Nola E, Moncharmont B, Medici N, Nigro V, Armetta I, Abbondanza C, Puca GA (2000) Estradiol induces functional inactivation of p53 by intracellular redistribution. Cancer Res 60: 2594–2597.\n- Musarrat J, Arezina WJ, Wani AA (1996) Prognostic and aetiological relevance of 8-hydroxyguanosine in human breast carcinogenesis. Eur J Cancer 32: 1209–1214.\n- Oliver CN, Ahn BW, Moerman EJ, Goldstein S, Stadtman ER (1987) Age-related changes in oxidized proteins. J Biol Chem 262: 5488–5491.\n- Olinski R, Siomek A, Rozalski R, Gackowski D, Foksinski M, Guz J, Dziaman T, Szpila A, Tudek B (2007) Oxidative damage to DNA and antioxidant status in aging and age-related diseases. Acta Biochim Polon 54: 11–26.\n- Refsgaard HH, Tsai L, Stadtman ER (2000) Modifications of proteins by polyunsaturated fatty acid peroxidation products. Proc Natl Acad Sci USA 97: 611–616.\n- Renke J, Popadiuk S, Korzon M, Bugajczyk B, Wozniak M (2000) Protein carbonyl groups’ content as a useful clinical marker of antioxidant barrier impairment in plasma of children with juvenile chronic arthritis. Free Radical Biol Med 29: 101–104.\n- Roy D, Liehr JG (1999) Estrogen, DNA damage and mutations. Mutat Res 424: 107–115.\n- Schnurr K, Hellwing M, Seidemann B, Jungblut P, Kuhn H, Rapoport SM, Schewe T (1996) Oxygenation of biomembranes by mammalian lipoxygenases: The role of ubiquinone. Free Radical Biol Med 20: 11–21.\n- Schreier S, Polnaszek CF, Smith IC (1978) Spin labels in membranes. Problems in practice. Biochim Biophys Acta 515: 395–436.\n- Shen L, Pisha E, Huang Z, Pezzuto JM, Krol E, Alam Z, van Breemen RB, Bolton JL (1997) Bioreductive activation of catechol estrogen-ortho-quinones: Aromatization of the B ring in 4-hydroxyequilenin markedly alters quinoid formation and reactivity. Carcinogenesis 18: 1093–1101.\n- Spink DC, Eugster HP, Linclon DW, Schuetz JD, Schuetz EG, Johnson JA, Kaminsky LS, Gierthy JF (1992) 17β-Estradiol hydroxylation catalyzed by human cytochrome P450 1A1: a comparison of the activities induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in MCF-7 cells with those from heterologous expression of the cDNA. Arch Biochem Biophys 293: 342–348.\n- Spink DC, Hayes CL, Young NR, Christou M, Sutter TR, Jefcoate CR, Gierthy JF (1994) The effects of 2,3,7,8-tetra-chlorodibenzo-p-dioxin on estrogen metabolism in MCF-7 breast cancer cells: evidence for induction of a novel 17α-estradiol 4-hydroxylase. J Steroid Biochem Mol Biol 51: 251–258.\n- Spink DC, Spink BC, Cao JQ, DePasquale JA, Pentecost BT, Fasco MJ, Li Y, Sutter TR (1998) Differential expression of CYP1A1 and CYP1B1 in human breast epithelial cells and breast tumor cells. Carcinogenesis 19: 291–298.\n- Stefaniak T, Krajewski J, Kobiela J, Makarewicz W, Stanek A, Asano M, Kondo R, Wakabayashi T, Gruca Z, Wozniak M (2002) Protein oxidation in male Syrian hamster kidney during estrogen-induced carcinogenesis. Pathophysiology 8: 269–273.\n- Thomas PD, Poznansky MJ (1990) A modified tetra-methylbenzidine method for measuring lipid hydroperoxides. Anal Biochem 188: 228–232.\n- Tsai L, Szweda PA, Vinogradova O, Szweda LI (1998) Structural characterization and immunochemical detection of a fluorophore derived from 4-hydroxy-2–nonenal and lysine. Proc Natl Acad Sci USA 95: 7975–7980.\n- Wellejus A, Loft S (2002) Receptor-mediated ethinylestradiol- induced oxidative DNA damage in rat testicular cells. FASEB J 16: 195–201.\n- Zhang F, Chen Y, Pisha E, Shen L, Xiong Y, van Breemen RB, Bolton JL (1999) The major metabolite of equilin, 4-hydroxyequilin, autoxidizes to an o-quinone which isomerizes to the potent cytotoxin 4-hydroxyequilenino-quinone. Chem Res Toxicol 12: 204–213.", "domain": "chemistry", "round": 3} +{"url": "https://dhfrinhibitor.com/2023/04/21/7046/", "date": "2023-12-04T10:37:15Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100527.35/warc/CC-MAIN-20231204083733-20231204113733-00541.warc.gz", "language_score": 0.829753041267395, "token_count": 932, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__277829650", "lang": "en", "text": "hannel induces K+ efflux out of cells. Together, these effects dramatically lower the K+ concentration in plant cells. K+uptake is hence dependent on active transport by way of K+/H+ symport mechanisms (HAK family members), that are driven by the proton motive force generated by H+-ATPase (48). A strong, good correlation involving H+-ATPase activity and salinity tension tolerance has been reported (56, 57). In rice, 5-HT Receptor Antagonist site OsHAK21 is crucial for salt tolerance at the seedling and germination stages (eight, 17). OsHAK21-mediated K+-uptake increased with lowering with the external pH (rising H+ concentration); this impact was abolished in the presence of your proton ionophore CCCP (SI Appendix, Fig. S15A), suggesting that OsHAK21 could act as a K+/H+ symporter, which depends upon the H+ gradient. OsCYB5-2 stimulation of OsHAK21-mediated K+uptake but not OsCYB5-2-OsHAK21 binding was also pH dependent (SI Appendix, Fig. S15 D ). Confirmation of synergistic effects of oxidoreduction and H+ concentration on OsHAK21 activity calls for further study. The CYB5-mediated OsHAK21 activation mechanism reported here differs from the posttranslational modifications that happen by means of phosphorylation by the CBL/CIPK pair (11, 19, 20), which likely relies on salt perception (which triggers calcium signals) (58). We propose that salt triggers association of ER-localized OsCYB5-2 with PM-localized OsHAK21, causing the OsHAK21 transporter to specifically and successfully capture K+. Consequently,Song et al. + An endoplasmic reticulum ocalized cytochrome b5 regulates high-affinity K transport in response to salt strain in riceOsHAK21 transports K+ inward to keep intracellular K+/ Na+ homeostasis, therefore improving salt tolerance in rice (Fig. 7F). Materials and AMPA Receptor Antagonist site MethodsInformation on plant materials employed, development circumstances, and experimental methods employed within this study is detailed in SI Appendix. The solutions involve the specifics on vector construction and plant transformation, co-IP assay, FRET evaluation, subcellular localization, yeast two-hybrid, histochemical staining, gene expression evaluation, LCI assay, BLI, plant treatment, and ion content determination. Facts of experimental situations for ITC are provided in SI Appendix, Table S1. Primers made use of in this study are listed in SI Appendix, Table S2.1. T. Horie et al., Two sorts of HKT transporters with various properties of Na+ and K+ transport in Oryza sativa. Plant J. 27, 12938 (2001). two. S. Shabala, T. A. Cuin, Potassium transport and plant salt tolerance. Physiol. Plant. 133, 65169 (2008). 3. U. Anschutz, D. Becker, S. Shabala, Going beyond nutrition: Regulation of potassium homoeostasis as a frequent denominator of plant adaptive responses to environment. J. Plant Physiol. 171, 67087 (2014). four. A. M. Ismail, T. Horie, Genomics, physiology, and molecular breeding approaches for improving salt tolerance. Annu. Rev. Plant Biol. 68, 40534 (2017). 5. T. A. Cuin et al., Assessing the part of root plasma membrane and tonoplast Na+/H+ exchangers in salinity tolerance in wheat: In planta quantification techniques. Plant Cell Environ. 34, 94761 (2011). 6. R. Munns, M. Tester, Mechanisms of salinity tolerance. Annu. Rev. Plant Biol. 59, 65181 (2008). 7. S. J. Roy, S. Negrao, M. Tester, Salt resistant crop plants. Curr. Opin. Biotechnol. 26, 11524 (2014). 8. Y. Shen et al., The potassium transporter OsHAK21 functions in the upkeep of ion homeostasis and tolerance to salt pressure in rice. Plant Cell Environ. 38, 2766779 (2015).", "domain": "chemistry", "round": 3} +{"url": "https://ndclist.com/ndc/61957-2988", "date": "2021-01-19T14:17:05Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-04/segments/1610703519395.23/warc/CC-MAIN-20210119135001-20210119165001-00663.warc.gz", "language_score": 0.7274986505508423, "token_count": 627, "dump": "CC-MAIN-2021-04", "global_id": "webtext-fineweb__CC-MAIN-2021-04__0__162277949", "lang": "en", "text": "The product labeling information includes all published material associated to a drug. Product labeling documents include information like generic names, active ingredients, ingredient strength dosage, routes of administration, appearance, usage, warnings, inactive ingredients, etc.\nTitanium Dioxide 1.75%\n- Helps prevent sunburn.If used as directed with other sun protection measures (\n- See Directions), decreases the risk of skin cancer and early skin aging caused by the sun.\nFor external use only.\nDo Not Use\nOn damaged or broken skin.\nWhen Using This Product,\nKeep out of eyes. Rinse with water to remove.\nStop Use And Ask A Doctor If\nKeep Out Of Reach Of Children.\nIf swallowed, get medical help or contact a Poison Control Center right away.\n- Apply liberally15 minutes before sun exposure.Reapply at least every 2 hours. Use water-resistant sunscreen if swimming or sweating. Sun Protection Measures. Spending time in the sun increases your risk of skin cancer and early skin aging. To decease this risk, regularly use sunscreen with a broad spectrum SPF of 15 or higher and other sun protection measures including:\n- Limit time in the sun, especially from 10 a.m.-2 p.m. wear long-sleeved shirts, pants, hats, and sunglasses.Children under 6 months of age: ask a doctor.\n- Protect the product in this container from excessive heat and direct sun.\nAQUA (WATER), METHYL TRIMETHICONE, ISODODECANE, ALCOHOL, DIMETHICONE, PEG-9 POLYDIMETHYLILOXY ETHYL DIMETHICONE, SILICA, ACRYLATE/IMETHICONE CO POLYMER, DIPHENYL DIMETHICONE/SILSEQUIOXANE COPOLYMER, METHYL METHACRYLATE CROSSPOLYMER, DISTEARDIMONIUM HECTORITE, BUTYLENE GLYCOL, SODIUM MYRISTYL GLUTAMATE, PHENOXYETHANOL, GLYCERYL UNDECYL DIMETHICONE, ALUMINUM HYDROXIDE, PROPYLENE CARBONATE, VP/VA COPLYMER, STEARIC ACID, PARFUM(FRAGRANCE), TETRASODIUM EDTA, VIOLA TRICOLOR EXTRACT, ROSA MULTIFLORE FRUIT EXTRACT, LINALOOL, LIMONENE, CITRONELLOL, ETHYLHEXYLGLYCERIN, TOCPHEROL.[MAY CONTAIN: CI 77163 (BISMUTH OXYCHLORIDE), CI 177493, CI 77492, CI 77499 (IRON OXIDE), CI 77891 (TITANIUM DIOXIDE)]. N 13117/Z\n* Please review the disclaimer below.", "domain": "chemistry", "round": 3} +{"url": "https://m.scirp.org/papers/34853", "date": "2020-02-17T13:19:09Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-10/segments/1581875142323.84/warc/CC-MAIN-20200217115308-20200217145308-00464.warc.gz", "language_score": 0.7855414152145386, "token_count": 712, "dump": "CC-MAIN-2020-10", "global_id": "webtext-fineweb__CC-MAIN-2020-10__0__15256187", "lang": "en", "text": "The phase structure of surfaces of steel samples, modified by pulse plasma processing, was analyzed using XRD and metallographic methods. It has been shown, that after pulse plasma processing under different conditions a modified structure consisting of three new phases, including austenite, iron nitride and carbide, is formed. The dependence of phase transition and microhardness on plasma flow parameters has been studied. A sharp decrease in the dimensions of ferrite crystallites after the impact of plasma flow is observed. The main purpose of hardening of common steel samples is formation of nano-dimension ferrite with oriented iron carbide on grains.\nCite this paper\nA. Zhukeshov, A. Gabdullina, A. Amrenova and S. Pak, \"Structure and Microhardness of Steel Samples after Pulse Plasma Flows Processing,\" Materials Sciences and Applications, Vol. 4 No. 7, 2013, pp. 35-41. doi: 10.4236/msa.2013.47A2006.\n V. V. Chebotarev, I. E. Garkusha, A. M. Bovda, et al., “Application of Pulsed Plasma Accelerators for Surface modification,” Nukleonika, Vol. 46, No. 1, 2001, pp. 27-30.\n Z. Peng, H. Miao and W. Wang, “Hard and Wear-Resistant Titanium Nitride Films for Ceramic Cutting Tools by Pulsed High Energy Density Plasma,” Surface and Coatings Technology, Vol. 166. No. 2-3, 2003, pp. 183-188.\n J. Langner, J. Piekoszewski, J. Stanisiawski and Z. Werner, “Present Status and Prospects of Research in SINS on the Modification of Surface Properties by Pulsed Plasma Streams,” Nukleonika, Vol. 45, No. 3, 2000, pp. 193-197.\n V. M. Anishik and V. V. Uglov, “Modification of Instrumental Materials by Ion and Plasma Beams,” BSU, Minsk, 2003, 191 p.\n V. V. Chebotarev, I. E. Garkusha, J. Langner, et al., “Surface Structure Changes Induced by Pulsed Plasma Streams Processing,” Problems of Atomic Science and Technology, Vol. 3, No. 3, 1999, pp. 273-275.\n F. B. Baimbetov, A. M. Zhukeshov and A. U. Amrenova, “Dynamics of Plasma Flow Formation in a Pulsed Accelerator Operating at a Constant Pressure,” Technical Physics Letters, Vol. 33, No. 1, 2007, pp. 77-79.\n A. M. Zhukeshov, “Plasma Flow Formation in a Pulse Plasma Accelerator in Continuous Filling Regime,” Plasma Devices and Operations, Vol. 17, No. 1, 2009, pp. 73-81. doi:10.1080/10519990802703319\n A. Zhukeshov, “Plasma Diagnostics in a Pulsed Accelerator Used for Material Processing,” Journal of Physics. Conference Series, Vol. 63, No. 01201, 2007.", "domain": "chemistry", "round": 3} +{"url": "https://www.scienceexchange.com/publications/12255", "date": "2021-09-22T08:35:43Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-39/segments/1631780057337.81/warc/CC-MAIN-20210922072047-20210922102047-00037.warc.gz", "language_score": 0.8590250015258789, "token_count": 316, "dump": "CC-MAIN-2021-39", "global_id": "webtext-fineweb__CC-MAIN-2021-39__0__72203418", "lang": "en", "text": "Human red cell differentiation requires the action of erythropoietin on committed progenitor cells. In iron deficiency, committed erythroid progenitors lose responsiveness to erythropoietin, resulting in hypoplastic anemia. To address the basis for iron regulation of erythropoiesis, we established primary hematopoietic cultures with transferrin saturation levels that restricted erythropoiesis but permitted granulopoiesis and megakaryopoiesis. Experiments in this system identified as a critical regulatory element the aconitases, multifunctional iron-sulfur cluster proteins that metabolize citrate to isocitrate. Iron restriction suppressed mitochondrial and cytosolic aconitase activity in erythroid but not granulocytic or megakaryocytic progenitors. An active site aconitase inhibitor, fluorocitrate, blocked erythroid differentiation in a manner similar to iron deprivation. Exogenous isocitrate abrogated the erythroid iron restriction response in vitro and reversed anemia progression in iron-deprived mice. The mechanism for aconitase regulation of erythropoiesis most probably involves both production of metabolic intermediates and modulation of erythropoietin signaling. One relevant signaling pathway appeared to involve protein kinase Calpha/beta, or possibly protein kinase Cdelta, whose activities were regulated by iron, isocitrate, and erythropoietin.", "domain": "chemistry", "round": 3} +{"url": "https://www.labmate-online.com/news/chromatography/1/ellutia-chromatography-solutions/enhancing-efficiency-and-accuracy-ellutias-automated-permeation-analyser/61354", "date": "2024-03-05T10:54:55Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707948234904.99/warc/CC-MAIN-20240305092259-20240305122259-00678.warc.gz", "language_score": 0.8620290756225586, "token_count": 346, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__166104497", "lang": "en", "text": "Enhancing Efficiency and Accuracy: Ellutia's Automated Permeation Analyser\nOct 10 2023\nThe global defence sectors acknowledge the critical significance of conducting accurate permeation rate tests on warfare materials. This procedure is essential for legal compliance and ensuring safety. However, the testing process required to confirm performance can be quite complex, often overwhelming standard analytical equipment. Manual testing can be time-consuming and potentially hazardous when confirming materials' performance against warfare agents.\nTo address these challenges, Ellutia provides a comprehensive system that automates this analysis. By utilising Ellutia's Automated Permeation Analyser, defence organisations can not only ensure prompt compliance with international standards but also benefit from a streamlined and automated testing framework.\nThe systems can be configured to meet various international standards, covering a wide range of challenge chemicals and material types. These systems consist of multiple permeation cells that house the challenge chemical and test materials. Samples are automatically taken at regular intervals, and the results are plotted in real-time.\nFor those in the defence and manufacturing sectors seeking to modernise their material testing methodologies, Ellutia encourages you to contact them directly. By doing so, they can better understand your requirements and help you find the best solution for your needs.\nMore information online\nIn This Edition Chromatography Articles - Comparing techniques for flow rate measurement in Liquid Chromatography Mass Spectrometry & Spectroscopy Articles - APGC: A Better Future with...\nView all digital editions\nMar 14 2024 Brussels, Belgium\nMar 17 2024 Monterey, CA, USA\nMar 17 2024 New Orleans, LA, USA\nMar 18 2024 Barcelona, Spain\nMar 26 2024 Milan, Italy", "domain": "chemistry", "round": 3} +{"url": "http://bhu.ac.in/science/isls/publications.php", "date": "2019-06-26T10:51:01Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-26/segments/1560628000266.39/warc/CC-MAIN-20190626094111-20190626120111-00006.warc.gz", "language_score": 0.6994635462760925, "token_count": 1012, "dump": "CC-MAIN-2019-26", "global_id": "webtext-fineweb__CC-MAIN-2019-26__0__82595749", "lang": "en", "text": "Kharwar RN, Mishra A, Gond SK, Stierle A and Stierle D (2011) Anticancer compounds derived from fungal endophytes: their importance and future challenges. Natural Product Reports 28: 1208-1228 (IF: 9.79)\nSivanandam TM and Thakur MK (2012) Traumatic brain injury: a risk factor for Alzheimer's disease. Neurosci Biobehav Rev. 36:1376-1381. (IF:9.10)\nOnorati MC, Lazzaro S, Mallik M, Ingrassia AMR, Carreca AP, Singh AK, Chaturvedi DP, Lakhotia SC and Corona DFV (2011) The ISWI chromatin remodeler organizes the hsrw ncRNA- containing omega speckle nuclear compartments. PLoS Genetics 7(5):e1002096.\nSingh S, Kumari R, Agrawal M and Agrawal SB (2012) Differential response of radish plants to supplemental ultraviolet-B radiation under varying NPK levels: chlorophyll fluorescence, gas exchange and antioxidants. Physiol. Plant 145(3):474-84. (IF: 7.054 )\nPandey SK, Haldar C, Patel DK and Maiti P (2013) Biodegradable polymers for potential delivery systems for therapeutics. Advances in Polymers Science 254: 169-202. (IF:6.723)\nShukla AK, Upadhyay SN and Dubey SK (2012) Current trends in trichloroethylene biodegradation: a review: Critical Reviews in Biotechnology 34(2):101-14. (IF: 6.472)\nMishra RK, Upadhyay KK, Shukla S and Mishra R (2012) Zinc (II) directed triple-stranded helicate incorporating nine membered metallamacrocycle: supramolecular cylinders mimicking P1 nuclease. Chem. Commun. 48: 4238-4240. (IF: 6.17)\nSrivastava S, Kumar V, Ali MA, Solanki PR, Srivastava A, Sumana G, Saxena PS, Joshi AG and Malhotra BD (2013) Electrophoretically deposited reduced graphene oxide platform for food toxin detection. Nanoscale 5 (7):3043-3051. (IF: 5.91)\nNarayan C. and Kumar A (2012) Constitutive over expression of IL-1ß, IL-6, NF-?B and Stat3 is a potential cause of lung tumorgenesis in urethane (ethyl carbamate) induced Balb/c mice. J Carcinogenes is (11:9) D0I10.4103/1477-3163.98965 (IF: 5.702)\nKonar A and Thakur MK (2014) Neuropsin expression correlates with dendritic marker MAP2c level in different brain regions of aging mice. Molec Neurobiol\nDOI 10.1007/s12035-014-8780-z (IF: 5.471)\nMaya K, Upadhyay SN, Singh RS and Dubey SK (2012) Degradation kinetics of chloropyrifos and 2,5,6-trichloro-2-pyridinol (TCP) by fungal communities. Bioresour.Technol.126:216-223. (IF: 5.352)\nBhutani S, Das A, Maheshwari M, Lakhotia SC and Jana NR (2012) Dysregulation of core components of SCF complex in poly-glutamine disorders Cell Death Disease3,e428.\nKant S, Kumar A and Singh SM (2012) Fatty acid synthase inhibitor orlistat induces apoptosis in T cell lymphoma: Role of cell survival regulatory molecules. BiochimBiophysActa.1820:1764-1773. (IF:5.269)\nPandey, S. Rai Rashmi and Rai L C (2012).Proteomics combines morphological, physiological and biochemical attributes to unravel the survival strategy of Anabaena sp. PCC 7120 under arsenic stress. Journal of Proteomics. 75: 921-937. (IF:5.113)\nS. Rathaur, Yadav M, Singh N and Singh A (2011) Effect of diethylcarbamazine, butylated hydroxy anisole and methyl substituted chalcone on filarial parasite Setaria cervi: proteomic and biochemical approaches. Journal of Proteomics 74: 1595–1606", "domain": "chemistry", "round": 3} +{"url": "https://www.victorypcb.com/news/how-to-remove-flux-from-pcb-6-easiest-ways.html", "date": "2023-09-28T13:42:46Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233510412.43/warc/CC-MAIN-20230928130936-20230928160936-00764.warc.gz", "language_score": 0.9281385540962219, "token_count": 1494, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__233267546", "lang": "en", "text": "Flux is a chemical cleanser that is extremely popular in the soldering of printed circuit boards globally. It assists in giving the board a spotless, corrosion-resistant surface so that the solder may successfully make a secure connection. Moreover, it stops oxidation, which can result in the failure of electrical connections.\nThis is important for PCB companies to learn about the ways they can remove flux PCB conveniently.\n1. No-Clean Flux: This flux is only used in selective or wave soldering and does not require to be cleaned after soldering. It is frequently constructed of rosin or resin mixed with halide activators and utilized in surface mount and through-hole components.\n2. Water Soluble Flux: This particular flux is used in wave soldering and after soldering, it needs to be well cleaned. It is typically composed of an organic acid chemical combined with an activator and is used in through-hole components.\n3. Organic Acid Flux: This kind of flux is utilized in wave soldering and needs to be thoroughly cleaned after soldering. It is typically composed of an organic acid compound combined with an activator and is used in surface mount as well as through components.\n4. High-Temperature Flux: The flux used in reflow soldering doesn't need to be cleaned up after soldering. It is typically composed of an organic acid substance combined with an activator and is used in surface mount components.\nFlux residues on the printed circuit board are also fairly well washed off with isopropyl, wood alcohol, isopropanol, acetone-based nail polish remover, and an alkaline solution with a 5% surfactant content.\nThere are also fluxes that leave no residue after use, but they give the board some haze, making it difficult to examine the radio components in detail if necessary. Therefore, it is recommended to wash off the remains of even such a “safe” flux.\nIn any case, in order not to form an oxide film, first of all, organic, rosin, and synthetic fluxes should be washed off. The composition can always be found on the packaging. At the same time, remember that rosin is the most difficult to remove from the board, so it is better for novice radio amateurs to avoid their use.\n1. Flux residue over time can corrode parts.\n2. Circuit board shorts can be brought on by flux residue.\n3. Electrical noise can be caused by flux.\n4. Flux residue has the possibility of damaging delicate components.\n5. Remaining flux might draw dust and grime.\n6. Flux can result in components not sticking to the board well.\n7. Subpar solder junctions may result from flux.\n1. Remove the flux residue with a brush or vacuum.\n2. Wipe the flux away using a moist cloth.\n3. Obtain flux removal solution, such as rosin, flux remover, or cleanser with a citrus base.\n4. To remove the flux, clean with a gentle toothbrush.\n5. In order to get rid of the flux, use a solvent such isopropyl alcohol.\n6. Heat the flux using a hot air gun to make it simpler to remove.\nFlux residue can be challenging to remove, but it is possible with the correct equipment and methods. The steps to remove flux residue are as follows:\n1. Gather the important equipment. A lint-free cloth, rubbing alcohol, cotton swabs, and flux remover are all required.\n2. Use the lint-free cloth to remove any extra flux residue first. In order to prevent scratching the surface, be careful to move in soft, circular motions.\n3. You can also use rubbing alcohol to gently remove any remaining residue. Apply the rubbing alcohol to the affected area with a cotton swab. Using the lint-free cloth, remove the leftover material.\n1. Remove any flux residue and other pollutants from the PCB by wiping it down with a lint-free cloth and rubbing alcohol.\n2. To get rid of dust and debris, use a vacuum cleaner if the PCB contains any substantial components.\n3. Air-dry the PCB or dry it off with a lint-free towel.\n4. Check the board for any faults or other issues and, if necessary, fix them.\n5. Use conformal coating to insulate the PCB from corrosion-causing moisture, dust, and other elements.\n6. Check the board's functionality one last time to ensure appropriate operation.\n1. you can use a soft, lint-free towel to wipe flux residue away.\n2. Add some liquid dish soap or mild detergent to a pitcher of warm water.\n3. Dip the towel in soapy water and clean away any leftover flux residue.\n4. Remove any soap residue by rinsing the towel in fresh water.\n5. To remove any leftover flux residue, wipe the area with a cotton swab dipped in isopropyl alcohol.\n6. Cleanse the area with water, then dry it with a soft, lint-free towel or cloth.\nYes, it is important to remove the flux from a PCB. Flux is a substance that aids in the solder's adhesion to the board during the soldering process. If left on the circuit board, it can function as an insulator and cause issues with the circuit. Also, it might draw dust, moisture, and other impurities that might result in corrosion or shorts.\nThe circuit board must be clear of pollutants that could harm it and the flux must be removed in order for the circuit to operate as intended.\nFlux remover, sometimes referred to as flux cleaning, is a chemical substance developed to dissolve and clear flux, and it can help you get rid of it swiftly and safely. You can use a brush, cloth, or spray can to apply flux remover. When using the flux remover, be sure to read and abide by all safety precautions on the container.\nAn excellent flux remover is available at Radioshack.\nI have discovered that the majority of flux removers lack the abrasiveness necessary to completely remove the flux. As a result, a small layer of flux residue remains that is resistant to the majority of flux removers.\nA printed circuit board might experience harm from flux if it is not properly removed after soldering. Electrical shorts, shoddy connections, and other reliability concerns can result from flux residue corroding and harming the copper traces and other components on the board.\nFlux can also make tracks and pads brittle, which can result in cracking and other types of damage.\nWe strongly recommend that you do not rub the board with a rag, as you can damage the leads of the radio components, which will lead to their displacement or malfunction due to signal loss.\nThis method is also suitable in case you went too far with the amount of flux when installing components, after soldering, and a flux spot was left at the work site. If it is not removed, the place will quickly darken, and the surface of the board may eventually lose the top layer at the point of contact.", "domain": "chemistry", "round": 3} +{"url": "https://www.hiyipro.com/sale-14143790-hqd-laboratory-hach-multiparameter-water-quality-meter-and-intellical-probes.html", "date": "2023-12-01T02:57:41Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100264.9/warc/CC-MAIN-20231201021234-20231201051234-00783.warc.gz", "language_score": 0.7009246945381165, "token_count": 461, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__146644497", "lang": "en", "text": "Laboratory Hach Multiparameter Water Quality Meter,\nIntellical Probes Hach Water Quality Meter,\nHach Multiparameter Water Quality Meter\nHQD meters connect with digital IntelliCALⓇ probes and automatically recognize the testing parameter, calibration history and method settings to minimize errors and setup time.\nIntelliCAL Red Rod pH electrodes offer exceptional performance and response time across a wide variety of sample types. The LBOD probe utilizes optical technology to provide fast, accurate Dissolved Oxygen (DO) measurements while dramatically reducing maintenance costs.\nAdditional probes for Conductivity, Total Dissolved Solids (TDS), Ammonia, Ammonium, Fluoride, Nitrate, Sodium, and RedOx (ORP) measurements complete the IntelliCAL portfolio.\n• Designed for drinking water and wastewater professionals.\n• Automatic probe and parameter recognition.\n• Instrument guided calibration procedures.\n• Calibration data stored in the probe.\n• Probe specific method settings for regulatory compliance and Good Laboratory Practice (GLP).\n• Real-time data logging with a USB connection.\n• Bi-directional communication with PC-based systems with a virtual serial port connection.\n• Sample ID and Operator ID for data traceability.\n• Adjustable automatic shut-off.\n• Durable, robust design to withstand years of use.\n|Part Number||Model||Contents||Probes included||Parameter||USD Price|\n|HQ440D||HQ440D – Multi/2 Channels||Meter Only||None||pH/Oxydo Reduction Potential (ORP)|\n|Compare||Conductivity/Total Dissolved Solid (TDS)/Salinity/Resistivity|\n|Dissolved Oxygen (DO)|\n|Biochemical Oxygen Demand (BOD)|\n|Ion Selective Electrode (ISE): Ammonia, Ammonium, Chloride, Fluoride, Nitrate, Sodium|\nBoiler Water | Cooling Water | Power | Water Treater | Drinking Water | Wastewater | Food and Beverage | Clean in Place (CIP) | Pool and Spa | Pulp and Paper\nContact Person: Lisa Niu", "domain": "chemistry", "round": 3} +{"url": "https://www.creative-diagnostics.com/Anti-MLLT10-PAb-193249-147.htm", "date": "2018-05-26T04:15:44Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-22/segments/1526794867309.73/warc/CC-MAIN-20180526033945-20180526053945-00517.warc.gz", "language_score": 0.7256988883018494, "token_count": 429, "dump": "CC-MAIN-2018-22", "global_id": "webtext-fineweb__CC-MAIN-2018-22__0__128473539", "lang": "en", "text": "Anti-MLLT10 polyclonal antibody (DPABH-03996)\nGoat anti-Human MLLT10 (aa 281-293) polyclonal antibody for WB\nBring this labeled antibody directly to your bench!\nOnline Inquiry Add to basket\nSynthetic peptide (C-RLEDTTARFTNAN) corresponding to internal sequence amino acids 281-293 of Human AF10 (NP_004632.1).\nWB: 1 - 3μg/ml\n*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.\nMLLT10; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10; AF10; protein AF-10; type I AF10 protein\nHave you cited DPABH-03996 in a publication? Let us know\nand earn a reward for your research.\nChan, WK; Sutherland, MK; et al. Antibody-Dependent Cell-Mediated Cytotoxicity Overcomes NK Cell Resistance in MLL-Rearranged Leukemia Expressing Inhibitory KIR Ligands but Not Activating Ligands. CLINICAL CANCER RESEARCH 18:6296-6305(2012).\nFlorian, MC; Nattamai, KJ; et al. A canonical to non-canonical Wnt signalling switch in haematopoietic stem-cell ageing. NATURE 503:392-+(2013).\nCustom Antibody Labeling\nWe offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody.", "domain": "chemistry", "round": 3} +{"url": "https://growdoc.ca/PlantProblem?Name=nutrient-burn", "date": "2023-12-07T14:39:19Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100674.56/warc/CC-MAIN-20231207121942-20231207151942-00062.warc.gz", "language_score": 0.8781941533088684, "token_count": 419, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__222058528", "lang": "en", "text": "Guess the Deficiency Game\nSee Plant Problems\nSee Similar Problems\nNutrient burn occurs when your plant consumes too many soluble minerals in one duration. Cannabis requires a specific level of PPM or EC for the corresponding growth stage. Overfeeding will cause your plant to push nutrients out towards the leaf tips causing them to burn up and even curl. Only in severe cases will the burning affect other parts of the leaf. This can happen from an over-saturated nutrient mix, growers trying to “push” their plants with stimulants or boosters or a pH imbalance.\nImages are listed below\nFlush with pH water. When refeeding, Follow a feeding schedule and adjust accordingly. If nutrient burn symptoms continue, try again at ¾ or less strength.\n• Flushing is important because even when dry your soil can still store nutrients. A good flush for at least 24 hours will wash away all remaining nutrients.\n• There are other organic methods to break down the nutrients and allow your plant accessibility to take them up.\n• Don't be alarmed if you see burnt tips early, as plant matures it will regulate nutrient uptake.\n• Avoid adding much synthetic fertilizer as this will raise the mineral uptake by your plant.\n• Plants uptake minerals quicker when grown Hydroponic as minerals are almost always soluble.\n• Make sure you are feeding your plant within the proper PPM and/or EC range. If you overfeed your hydroponic plants, try to add pH'd water to dilute, or replace your water with a fresh mix with fertilizer at ½ strength. This will slow down the process of mineral consumption while ensuring your plant is still feeding.\nIf your light isn't strong enough, your plant won't have to work as hard, thus not needing to use all the nutrients provided. A stronger light will encourage photosynthesis, leading to a hungry plant.\n*Affected leaves usually do not recover from damage even after correcting the problem.*\nShare this page and Earn Credits!\nLogin/Register for free to Earn Credits!", "domain": "chemistry", "round": 3} +{"url": "https://www.multikraft.com/en/shop/detail/index/sArticle/182/sCategory/480", "date": "2021-12-03T06:11:03Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-49/segments/1637964362605.52/warc/CC-MAIN-20211203060849-20211203090849-00384.warc.gz", "language_score": 0.9000157713890076, "token_count": 374, "dump": "CC-MAIN-2021-49", "global_id": "webtext-fineweb__CC-MAIN-2021-49__0__163577854", "lang": "en", "text": "The product was successfully added to your shopping cartView shopping cart\nOverview of all areas of use, tips and dosing information, German\nThe EM user catalogue is a comprehensive guide to EM, which you can use to discover the world of Effective Microorganisms. The 192 page EM user catalogue include numerous possible applications and uses and provides precise dosing recommendations and quantity information. It also contains extracts from academic studies and investigations. Practical examples from other EM users, more detailed tips and tricks and comic strips for individual applications are clearly presented.\nMixing the paint with Effective Microorganisms counters aggressive substances and ensures a pleasant indoor environment immediately after painting.applications.show_details\nThe use of EM Ceramic Powder for Construction eliminates harmful substances in the materials used.applications.show_details\nThe environmentally-friendly method keeps drains clean for much longer and blockages only occur very rarely, if at all.applications.show_details\nEM Ceramics reduces the size of water clusters in drinking water, which enables better transfer of nutrients and minerals into the cells and more effective removal of harmful substances.applications.show_details\nThe EM Ceramic Water Reactor improves the water quality throughout the household, changes the structure of limescale and prevents it from accumulating in pipes.applications.show_details\nDaniel Zippel is an EM advisor and an expert on issues such as the production and functioning of EM Ceramics. He has been successfully using Effective Microorganisms - particularly EM Ceramics - since 2003. \"One of my specialist areas is the building sector.\nFor pretreatment of old masonry I spray on EM Clear active for a natural drainage process or for mould-resistant painting in damp rooms I mix Amron A powder into the paint. These two methods have been very successful for me.\"", "domain": "chemistry", "round": 3} +{"url": "https://iovs.arvojournals.org/article.aspx?articleid=2271328", "date": "2019-01-16T09:30:28Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-04/segments/1547583657097.39/warc/CC-MAIN-20190116073323-20190116095323-00094.warc.gz", "language_score": 0.889774739742279, "token_count": 490, "dump": "CC-MAIN-2019-04", "global_id": "webtext-fineweb__CC-MAIN-2019-04__0__213579727", "lang": "en", "text": "Purchase this article with an account.\nRachel M. Roberson, Karan Uppal, L. Goodwin Burgess, ViLinh Tran, John Kuchtey, Rachel W Kuchtey, Dean P Jones, Milam A Brantley; Metabolic profiles associated with primary open-angle glaucoma. Invest. Ophthalmol. Vis. Sci. 2014;55(13):5703.\nDownload citation file:\n© ARVO (1962-2015); The Authors (2016-present)\nTo determine if primary open-angle glaucoma (POAG) patients can be differentiated from controls based on metabolic characteristics.\nWe performed metabolomic analysis using C18 liquid chromatography-Fourier-transform mass spectrometry on frozen plasma samples from 72 POAG patients and 72 controls. Data were collected from mass/charge ratio (m/z) 85-2000 on a Thermo LTQ-Velos Orbitrap mass spectrometer. Metabolic features were extracted with xMSanalyzer and filtered using log2 fold change in order to isolate differentially expressed metabolites (DEMs). P-values were corrected using Benjamini and Hochberg False Discovery Rate (FDR) to account for multiple testing. Metabolome-wide Spearman correlation was performed for the DEMs to identify top correlated features. DEMs and top correlated features were matched to the Metlin metabolomics database and further analyzed with MetaboAnalyst to identify metabolic pathways most significantly altered in POAG.\nAfter data filtering, 2440 m/z features were recovered from the 144 plasma samples. Forty-one features were significantly different between POAG patients and controls using FDR (q=0.05). These discriminating features included palmitoyl carnitine and sphingosine metabolites, each previously linked to glaucoma. Pathway analysis of the 41 m/z features and their correlated features revealed galactose metabolism, fructose and mannose metabolism, and steroid hormone biosynthesis pathways to be associated with disease status.\nMetabolomics can identify both individual metabolites and metabolic pathways that discriminate POAG cases from controls. These results suggest palmitoyl carnitine and sphingosine metabolites, as well as carbohydrate metabolism and steroid hormone biosynthesis pathways, to be involved in POAG pathophysiology.\nThis PDF is available to Subscribers Only", "domain": "chemistry", "round": 3} +{"url": "https://www.ncbs.res.in/content/%CE%B1-synuclein-aggregation-intermediates-form-fibril-polymorphs-distinct-prion-properties", "date": "2024-02-21T15:56:30Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707947473518.6/warc/CC-MAIN-20240221134259-20240221164259-00041.warc.gz", "language_score": 0.8057026863098145, "token_count": 380, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__163479786", "lang": "en", "text": "α-Synuclein aggregation intermediates form fibril polymorphs with distinct prion-like properties.\n|α-Synuclein aggregation intermediates form fibril polymorphs with distinct prion-like properties.\n|Year of Publication\n|Mehra S, Ahlawat S, Kumar H, Datta D, Navalkar A, Singh N, Patel K, Gadhe L, Kadu P, Kumar R, Jha NN, Sakunthala A, Sawner AS, Padinhateeri R, Udgaonkar JB, Agarwal V, Maji SK\n|J Mol Biol\n|2022 Jul 27\nα-Synuclein (α-Syn) amyloids in synucleinopathies are suggested to be structurally and functionally diverse, reminiscent of prion-like strains. But how the aggregation of the same precursor protein results in the formation of fibril polymorphs remains elusive. Here, we demonstrate the structure-function relationship of two polymorphs, pre-matured fibrils (PMFs) and helix-matured fibrils (HMFs), based on α-Syn aggregation intermediates. These polymorphs display the structural differences as demonstrated by solid-state NMR and mass spectrometry studies and also possess different cellular activities such as seeding, internalization, and cell-to-cell transfer of aggregates. HMFs with a compact core structure exhibit low seeding potency but readily internalize and transfer from one cell to another. The less structured PMFs lack transcellular transfer ability but induce abundant α-Syn pathology and trigger the formation of aggresomes in cells. Overall, the study highlights that the conformational heterogeneity in the aggregation pathway may lead to fibril polymorphs with distinct prion-like behavior.\n|J Mol Biol", "domain": "chemistry", "round": 3} +{"url": "https://pubmed.ncbi.nlm.nih.gov/9516199/?dopt=Abstract", "date": "2022-01-18T10:59:31Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-05/segments/1642320300810.66/warc/CC-MAIN-20220118092443-20220118122443-00356.warc.gz", "language_score": 0.9516852498054504, "token_count": 266, "dump": "CC-MAIN-2022-05", "global_id": "webtext-fineweb__CC-MAIN-2022-05__0__10791504", "lang": "en", "text": "Treatments available to improve compliance in surfactant-deficient states include exogenous surfactant (ES) and either partial (PLV) or total liquid ventilation (TLV) with perfluorochemical (PFC). Because of the additional air-lung and air-PFC interfaces introduced during PLV compared with TLV, we hypothesized that compliance would be worse during PLV than during TLV. Because surfactant is able to reduce interfacial tension between air and lung as well as between PFC and lung, we further hypothesized that compliance would improve with surfactant treatment before PLV. In excised preterm lamb lungs, we used Survanta for surfactant replacement and perflubron as the PFC. Compliance during PLV was intermediate between TLV and gas inflation, both with and without surfactant. Surfactant improved compliance during PLV, compared with PLV alone. Because of the force-balance equation governing the behavior of immiscible droplets on liquid surfaces, we predict that PFC droplets spread during PLV to cover the alveolar surface in surfactant-deficient lungs during most of lung inflation and deflation but that the PFC would retract into droplets in surfactant-sufficient lungs, except at end inspiration.", "domain": "chemistry", "round": 3} +{"url": "http://www.sinobiological.com/commodity~23602~product.html", "date": "2017-03-26T07:35:22Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-13/segments/1490218189130.57/warc/CC-MAIN-20170322212949-00033-ip-10-233-31-227.ec2.internal.warc.gz", "language_score": 0.823924720287323, "token_count": 726, "dump": "CC-MAIN-2017-13", "global_id": "webtext-fineweb__CC-MAIN-2017-13__0__117387352", "lang": "en", "text": "|Datasheet||Specific References||Reviews||Related Products||Protocols|\n|Vector Type||Mammalian Expression Vector|\n|Expression Method||Constiutive, Stable / Transient|\n|Selection In Mammalian Cells||Hygromycin|\nFLAG-tag, or FLAG octapeptide, is a polypeptide protein tag that can be added to a protein using recombinant DNA technology. It can be used for affinity chromatography, then used to separate recombinant, overexpressed protein from wild-type protein expressed by the host organism. It can also be used in the isolation of protein complexes with multiple subunits.\nA FLAG-tag can be used in many different assays that require recognition by an antibody. If there is no antibody against the studied protein, adding a FLAG-tag to this protein allows one to follow the protein with an antibody against the FLAG sequence. Examples are cellular localization studies by immunofluorescence or detection by SDS PAGE protein electrophoresis.\nThe peptide sequence of the FLAG-tag from the N-terminus to the C-terminus is: DYKDDDDK (1012 Da). It can be used in conjunction with other affinity tags, for example a polyhistidine tag (His-tag), HA-tag or myc-tag. It can be fused to the C-terminus or the N-terminus of a protein. Some commercially available antibodies (e.g., M1/4E11) recognize the epitope only when it is present at the N-terminus. However, other available antibodies (e.g., M2) are position-insensitive.\nE3 ubiquitin-protein ligase Itchy homolog, also known as Atrophin-1-interacting protein 4, NFE2-associated polypeptide 1, NAPP1 and ITCH, is a cell membrane protein which contains one C2 domain, one HECT (E6AP-type E3 ubiquitin-protein ligase) domain and contains four WW domains. ITCH acts as an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It catalyzes 'Lys-29'-, 'Lys-48'- and 'Lys-63'-linked ubiquitin conjugation. ITCH is involved in the control of inflammatory signaling pathways. It is an essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, TAX1BP1 and RNF11, that ensures the transient nature of inflammatory signaling pathways. ITCH promotes the association of the complex after TNF stimulation. Once the complex is formed, TNFAIP3 deubiquitinates 'Lys-63' polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteosomal degradation and consequently termination of the TNF- or LPS-mediated activation of NFKB1. Defects in ITCH are the cause of syndromic multisystem autoimmune disease (SMAD) which is characterized by organomegaly, failure to thrive, developmental delay, dysmorphic features and autoimmune inflammatory cell infiltration of the lungs, liver and gut.", "domain": "chemistry", "round": 3} +{"url": "http://pctermpaperkwqz.communiquepresse.info/human-insulin-and-recombinant-dna-technology-essay.html", "date": "2018-10-24T04:39:41Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-43/segments/1539583519859.77/warc/CC-MAIN-20181024042701-20181024064201-00464.warc.gz", "language_score": 0.8650452494621277, "token_count": 926, "dump": "CC-MAIN-2018-43", "global_id": "webtext-fineweb__CC-MAIN-2018-43__0__208309942", "lang": "en", "text": "Human insulin and recombinant dna technology essay\n2018-7-5 recombinant dna technology is a an extremely successful example of this particular use is the case of insulin recombinant dna using the human gene. The debated applications of recombinant dna technology of human protein from a single gene of insulin of recombinant dna technology essay. 2018-6-7 new topic dna in science and technology essay human physiology recombinant dna technology is the technology in the synthesis of human insulin. Recombinant dna technology gene cloning biology essay as human insulin cloning of pmb insert inside the competant cell biology essay dna recombinant.\n2016-7-28 recombinant dna technology synthetic insulin production using recombinant dna edit template:essay-like ↑ human insulin from recombinant dna technology. Thanks to recombinant dna technology, recombinant human gh of recombinant dna technology essay through recombinant dna technology this insulin. 2018-8-13 in recent years science has been using recombinant dna to genetically modify animals, plants and now technology has advanced to the point where there is constant speculation on manipulating human dna. Recombinant dna and ethics kaitlyn a ieradi university of we are leaning more toward human-derived insulin, as dna and recombinant dna technology essay.\nWhich best describes the process of making recombinant dna the basis of dna technology the insertion of the human insulin gene into the bacterium. The objectives of recombinant dna technology let us write you a custom essay bovine and porcine insulin was used which was very similar to human insulin but. Genetic engineering ex inserting the human insulin gene into bacteria to mass produce it recombinant dna technology 1973.\n2015-3-23 the technology of recombinant dna is a dna based major tool products like human insulin recombinant dna technology is a form of genetic. Insulin, human recombinant dry powder, this genetically engineered human insulin is a full sequence molecule producted by recombinant dna technology in baker′s. 2017-12-5 introduction recombinant dna molecules are new artificial dna strands that are produced by combining two unrelated (non-homologous) genes, for example: hybrid of e coli plasmid with human insulin gene.\nTechnology of recombinant dna biology essay is termed as familial technology the find of recombinant dna has been a merchandises like human insulin. The use of recombinant dna technology recombinant dna technology is the technology of preparing recombinant dna in vitro by cutting up dna molecules and splicing together fragments from more than one organism(1) this is the process of using recombinant dna technology to enable the rapid production of human protein from a single gene of insulin. 2009-7-31 ethical issues in genetic modification had developed recombinant dna technology, gm for the production of pharmaceuticals such as human insulin. Recombinant dna technology has been used to create different types of medicines for example human insulin people with diabetes do not produce enough insulin for their own bodies, and in a lot of cases, they are allergic to non-human insulin.\n2007-10-5 also known as: biotechnology, gene splicing, recombinant dna technology soon after the publication of the short essay by crick and watson on dna human insulin. 2018-8-9 recombinant dna technology in the synthesis of this is really a beautiful web page with integrated text and images that shows, in-depth, how human insulin is produced using recombinant dna technology. 2018-8-18 human genome project essay although similar to human insulin, the human protein produced by bacteria with recombinant dna,. Human insulin and recombinant dna technology essay sample “diabetes mellitus is a heterogeneous group of chronic disorders that manifest as high levels of blood glucose, and which result from impaired insulin action or production” (power, 2005 national diabetes information clearinghouse, nd.\nRecombinant dna technology used for insulin exactly match with the human insulin there are one or in the subject of recombinant dna technology. 2018-8-19 the use of recombinant dna technology essay length: 840 recombinant dna technology to enable the rapid production of human protein from a single gene of insulin. 2009-3-9 in genetics recombinant dna technology has many uses e recombinant dna technology in the synthesis of human as in case of recombinant insulin, three.", "domain": "chemistry", "round": 3} +{"url": "http://www.selectscience.net/mass-spectrometry-(materials)/product-directory/gc-tof/?catID=3186&u=A583512F-C32E-4032-B823-CDC4967ECD1B", "date": "2015-11-27T20:40:36Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2015-48/segments/1448398450559.94/warc/CC-MAIN-20151124205410-00101-ip-10-71-132-137.ec2.internal.warc.gz", "language_score": 0.7938104271888733, "token_count": 617, "dump": "CC-MAIN-2015-48", "global_id": "webtext-fineweb__CC-MAIN-2015-48__0__22778858", "lang": "en", "text": "Latest: Human Biomonitoring: Parts per Quintillion— A New Frontier for Toxicologists and Risk Ass...\nLatest: Incidence of Free Light Chain Escape in Multiple Myeloma, Why is it Increasing?\nLatest: 6 Innovations in Drug Discovery Screening\nLatest: Prevent the Antibiotic Apocalypse with the MaxSignal Colistin ELISA Test Kit\nLatest: The Latest Technologies and Methods for Environmental Research\nLatest: SCIEX Launches Brand New High Resolution Mass Spec System Designed Exclusively for Routin...\nLatest: Automatic White Balancing and Brightness Matching in a 1-Step Batch Process\nFree SelectScience Webinar: Experts at AstraZeneca Evaluate the Latest in GC-MS Technology for Phar...\nIncidence of Free Light Chain Escape in Multiple Myeloma, Why is it Increasing?\nSimple Swab Test Taking the Guess Work Out of Antibiotic Prescription\nHuman Biomonitoring: Parts per Quintillion— A New Frontier for Toxicologists and Risk Assessor\n6 Innovations in Drug Discovery Screening\nThe Latest Technologies and Methods for Environmental Research\nTG-IR Analysis of Layers of a Cable Used in the Automotive Industry\nThe Effect of Irradiation on Sodium Alginate\nAdvancements in Atmospheric-Vacuum Interfaces of Mass Spectrometers with Increased Gas Th...\nHow Flat is Your Confocal Illumination Profile?\nEthanol Solutions for MVS® Volume Verifications\nRapid Bacterial Detection with the Sirius L Tube Luminometer\n12 Dec 2015-16 Dec 2015\n23 Jan 2016-27 Jan 2016\nBenchTOF is an innovative time-of-flight (TOF) mass spectrometer designed specifically for gas chromatography (GC). It has a bench-top design and de... Read more...\nGCxGC, combined with the Pegasus HT TOFMS, changes the perspective of complex sample analysis. No longer limited to two analytical dimensions, the Pe... Read more...\nWhile some systems on the market offer users a choice between acquisition speed or resolution, the Pegasus GC-HRT provides scientists with an unprece... Read more...\nThe Pegasus® HT TOFMS system combines GC-TOFMS technology with advanced ChromaTOF® software to provide an unparalleled increase in laboratory produc... Read more...\nThe GCT Premier™ benchtop orthogonal acceleration time-of-flight (oa-TOF) mass spectrometer delivers high sensitivity, resolution, and exact mass m... Read more...\nAgilent 7200B Series GC/Q-TOF: expanding on the world’s leading GC/Q-TOF. The new Agilent 7200B GC/Q-TOF is a second generation instrument with i... Read more...\nThe combination of a TGA with a MS allows you to detect very low levels of impurities in real time.\nBy heating a sample on the TGA, the sample w... Read more...", "domain": "chemistry", "round": 3} +{"url": "https://iranplast10.nipna.ir/en/newsagency/26239/Petchem-Expansion-Initiatives-Commence-at-Bandar-Imam", "date": "2024-03-05T05:14:29Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707948217723.97/warc/CC-MAIN-20240305024700-20240305054700-00361.warc.gz", "language_score": 0.8882800936698914, "token_count": 343, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__76798255", "lang": "en", "text": "The ceremony, attended by Morteza Shahmirzaei, Deputy Minister of\nPetroleum, and Sepahdar Ansari Nik, CEO of the Bandar Imam Petrochemical\nCompany, marked the commencement of the construction of a Chlor-Alkali unit\nwith a capacity of 300 thousand tons and a Caustic Soda unit with a capacity of\nConstruction of these units, which is expected to span 32 months, is\npoised to expedite the completion of the value chain in this petrochemical\ncomplex. Upon completion, the final products from these units will be utilized\nas feedstock in the PVC units, slated for construction in the near future.\nThe addition of the Chlor-Alkali and Caustic Soda units is set to\nincrease the production capacity of Bandar Imam Petrochemical Company,\ncontributing significantly to the development of the petrochemical sector and fostering\nInauguration of Petchem Museum at Bandar Imam\nSimultaneously, in conjunction with the commemoration of the 50th\nanniversary of Bandar Imam Petrochemical Complex, a Petrochemical Museum was\nofficially inaugurated today. The opening ceremony was graced by the presence\nof Deputy Minister of Petroleum Morteza Shahmirzaei and the CEO of the Bandar\nImam Petrochemical Company.\nThe establishment of the Petrochemical Museum stands as a testament to\nthe rich history and achievements of Bandar Imam Petrochemical Complex over the\npast five decades.\nIt serves as a platform to showcase the evolution and advancements in\nthe petrochemical industry, providing valuable insights into its contributions\nto the national economy and industrial landscape.", "domain": "chemistry", "round": 3} +{"url": "https://digitalcommons.uri.edu/pls_facpubs/53/", "date": "2023-09-25T06:08:38Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233506686.80/warc/CC-MAIN-20230925051501-20230925081501-00899.warc.gz", "language_score": 0.8085077404975891, "token_count": 557, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__200012378", "lang": "en", "text": "Synergism between deinethylation inhibitor fungicides or Gibberellin inhibitor plant growth regulators and bifenthrin in a pyrethroid-resistant population of Listronotus maculicollis (Coleoptera: Curculionidae)\nDate of Original Version\nIn 20072008, the \"annual bluegrass weevil,\" Listronotus maculicollis Kirby (Coleoptera: Curculionidae), a serious pest of Poa annua L. (Poales: Poaceae) on U.S. golf courses, was shown to be resistant to two pyrethroids, bifenthrin and lambda-cyhalothrin. In 2008, we showed that bifenthrin resistance was principally mediated by oxidase detoxification (cytochrome P450 [P450]). P450s can be inhibited by demethylation inhibitor fungicides and gibberellin inhibitor plant growth regulators, both of which are commonly used on golf courses. We tested these compounds for synergistic activity with bifenthin against a pyrethroid-resistant population of L. maculicollis. The LD50 value for bifenthrin was significantly reduced from 87 ng per insect (without synergists) to 9.6-40 ng per insect after exposure to the fungicides fenarimol, fenpropimorph, prochloraz, propiconazole, and pyrifenox and the plant growth regulators flurprimidol, paclobutrazol, and trinexapac-ethyl. Simulated field exposure with formulated products registered for use on turf revealed enhanced mortality when adult weevils were exposed to bifenthrin (25% mortality, presented alone) combined with field dosages of propiconizole, fenarimol, flurprimidol, or trinexapac-ethyl (range, 49-70% mortality). © 2010 Entomological Society of America.\nPublication Title, e.g., Journal\nJournal of Economic Entomology\nRamoutar, D., R. S. Cowles, E. Requintina, and S. R. Alm. \"Synergism between deinethylation inhibitor fungicides or Gibberellin inhibitor plant growth regulators and bifenthrin in a pyrethroid-resistant population of Listronotus maculicollis (Coleoptera: Curculionidae).\" Journal of Economic Entomology 103, 5 (2010). doi: 10.1603/EC09374.", "domain": "chemistry", "round": 3} +{"url": "https://itstillruns.com/difference-between-jp5-diesel-fuel-7582727.html", "date": "2024-02-22T15:27:51Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707947473819.62/warc/CC-MAIN-20240222125841-20240222155841-00521.warc.gz", "language_score": 0.9568114876747131, "token_count": 311, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__11868440", "lang": "en", "text": "What Is the Difference Between JP5 & Diesel Fuel?by Mike Schoonveld\nDiesel fuel may be made from crude oil, while JP5 fuel is always refined from crude oil. The initial refining process for both are similar. Further refining and additives, however, make them completely different products.\nDiesel fuel is any fuel designed to be used in a diesel engine. Most diesel fuel is refined from crude oil, but increasingly, diesel made from biomass or natural gas is becoming available.\nJP5 fuel is a jet-propulsion fuel made to strict military specifications. Based on kerosene, the most significant difference between JP5 and other jet fuels is it has a higher flash point and is required for use on carrier-based aircraft.\nJP5 fuel is widely available around the world and meets military specifications for NATO, the United States, Great Britain and other countries. Diesel fuel is also available worldwide but which grade or grades are available in any particular spot is determined more by the climate or season of the year than the types of diesel engines in which the fuel will be used. Thinner grades or fuels with special anti-gel additives are required to keep the fuel from gelling in cold weather areas.\nMike Schoonveld has been writing since 1989 with magazine credits including \"Outdoor Life,\" \"Fur-Fish-Game,\" \"The Rotarian\" and numerous regional publications. Schoonveld earned a Master Captain License from the Coast Guard. He holds a Bachelor of Science in wildlife science from Purdue University.", "domain": "chemistry", "round": 3} +{"url": "https://www.usgs.gov/publications/reconnaissance-signs-mississippi-valley-type-lead-zinc-mineralizing-system-eastern", "date": "2023-09-21T20:29:08Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233506029.42/warc/CC-MAIN-20230921174008-20230921204008-00495.warc.gz", "language_score": 0.8637071847915649, "token_count": 324, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__107162499", "lang": "en", "text": "Reconnaissance field visits and rock sampling were conducted at eight geologically selected locations within Mesozoic rocks on the eastern flank of the Rutbah Uplift, Anbar Province, western Iraq, in an attempt to determine if these rocks have been affected by a Mississippi Valley-Type (MVT) lead-zinc mineralizing system. Samples subsequently were studied by carbonate mineral staining, transmitted and reflected light petrology, and scanning electron microscopy with semi-quantitative energy dispersive elemental analyses. Single samples were studied by each, inductively coupled plasma mass spectrometry analyses of trace elements and fluid inclusion microthermometry. Permissive evidence indicates that there has been a MVT system present, but none of the evidence is considered definitive.\n|Title||A reconnaissance for signs of a Mississippi Valley-type lead-zinc mineralizing system on the eastern flank of the Rutbah Uplift, Anbar Province, Iraq|\n|Authors||Timothy S. Hayes, Mazin Mustafa, Thair Bennet|\n|Publication Subtype||USGS Numbered Series|\n|Series Title||Open-File Report|\n|Record Source||USGS Publications Warehouse|\n|USGS Organization||Geology, Minerals, Energy, and Geophysics Science Center|", "domain": "chemistry", "round": 3} +{"url": "https://chemrxiv.org/engage/chemrxiv/article-details/60c74ab2469df4ae80f43dc0", "date": "2023-03-27T06:58:56Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-14/segments/1679296948609.41/warc/CC-MAIN-20230327060940-20230327090940-00604.warc.gz", "language_score": 0.9243388772010803, "token_count": 314, "dump": "CC-MAIN-2023-14", "global_id": "webtext-fineweb__CC-MAIN-2023-14__0__255452004", "lang": "en", "text": "Extracellular vesicles (EVs) have attracted great interest among researchers due to their role in cell-cell communication, disease diagnosis, and drug delivery. In spite of their potential in the medical field, there is no consensus on the best method for separating microvesicles from cell culture supernatant and complex biological fluids. Obtaining a good recovery yield and preserving physical characteristics is critical for the diagnostic and therapeutic use of EVs. The separation is made complex by the fact that blood and cell culture media, contain a large number of nanoparticles in the same size range. Methods that exploit immunoaffinity capture provide high purity samples and overcome the issues of currently used separation methods. However, the release of captured nanovesicles requires harsh conditions that hinder their use in certain types of downstream analysis. Herein, a novel capture and release approach for small extracellular vesicles (sEVs), based on DNAdirected immobilization of antiCD63 antibody is presented. The flexible DNAlinker increases the capture efficiency and allows releasing of EVs by exploiting the endonucleasic activity of DNAse I. This separation protocol works under mild conditions, enabling the release of intact vesicles that can be successfully analyzed by imaging techniques. In this article sEVs recovered from plasma were characterized by established techniques for EVs analysis including nanoparticle tracking and transmission electron microscopy.\nSeparation of extracellular vesicles by DNA-directed immunocapturing followed by enzymatic release - Supporting Information", "domain": "chemistry", "round": 3} +{"url": "https://research-information.bris.ac.uk/en/publications/characterization-of-a-novel-focal-adhesion-kinase-inhibitor-in-hu", "date": "2022-06-27T07:48:04Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-27/segments/1656103329963.19/warc/CC-MAIN-20220627073417-20220627103417-00216.warc.gz", "language_score": 0.9060204029083252, "token_count": 440, "dump": "CC-MAIN-2022-27", "global_id": "webtext-fineweb__CC-MAIN-2022-27__0__103490928", "lang": "en", "text": "Focal adhesion kinase (FAK) is activated in human platelets downstream of integrins, e.g. alpha(IIb)beta(3), and other adhesion receptors e.g. GPVI. Mice in which platelets lack FAK have been shown to exhibit extended bleeding times and their platelets have been shown to display decreased spreading on fibrinogen-coated surfaces. Recently, a novel FAK inhibitor (PF-573,228) has become available, its selectivity for FAK shown in vitro and in cell lines. We determined the effect of this inhibitor on platelet function and signaling pathways. Like murine platelets lacking FAK, we found that PF-573,228 was effective at blocking human platelet spreading on fibrinogen-coated surfaces but did not affect the initial adhesion. We also found a reduced spreading on CRP-coated surfaces. Further analysis of the morphology of platelets adhered to these surfaces showed the defect in spreading occurred at the transition from filopodia to lamellipodia. Similar to that seen with murine neutrophils lacking FAK, we also observed an unexpected defect in intracellular calcium release in human platelets pre-treated with PF-573,228 which correlated with impaired dense granule secretion and aggregation. The aggregation defect could be partially rescued by addition of ADP, normally secreted from dense granules, suggesting that PF-573,228 has effects on FAK downstream of alpha(IIb)beta(3) and elsewhere. Our data show that PF-573,228 is a useful tool for analysis of FAK function in cells and reveal that in human platelets FAK may regulate a rise in cell calcium and platelet spreading.\n|Translated title of the contribution||Characterization of a novel focal adhesion kinase inhibitor in human platelets|\n|Pages (from-to)||198 - 203|\n|Journal||Biochemical and Biophysical Research Communications|\n|Publication status||Published - Nov 2009|", "domain": "chemistry", "round": 3} +{"url": "https://www.phosphosolutions.com/products/anti-enos-antibody-np2281", "date": "2023-09-27T04:37:23Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233510259.52/warc/CC-MAIN-20230927035329-20230927065329-00214.warc.gz", "language_score": 0.8963698744773865, "token_count": 725, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__108135972", "lang": "en", "text": "Western blot analysis of human umbilical vein endothelial cells before (lanes 1, 3, 5) and after (lanes 2, 4, 6) treatment with lambda phosphatase. The blots were probed with anti-endothelial Nitric Oxide Synthase (eNOS) monoclonal antibody (lanes 1 & 2), anti-eNOS (Ser-632) phospho-specific antibody (lanes 3 & 4), and anti-eNOS polyclonal antibody (lanes 5 & 6).\nBulk Order Anti-eNOS Antibody\nNitric oxide (NO) has a broad range of biological activities and is implicated in signaling pathways in phylogenetically diverse species. Nitric oxide synthases (NOS), the enzymes responsible for synthesis of NO, are homodimers whose monomers are themselves two fused enzymes: a cytochrome reductase and a cytochrome that requires three cosubstrates (L-arginine, NADPH, and oxygen) and five cofactors or prosthetic groups (FAD, FMN, calmodulin, tetrahydrobiopterin, and heme). Several distinct NOS isoforms are produced from three distinct genes. The inducible form of NOS, iNOS (NOS-II), is Ca2+ independent and is expressed in a broad range of cell types, and two constitutive Ca2+/CaM-dependent forms of NOS: nNOS (bNOS, NOS-I) identified in neurons and eNOS (ecNOS, NOS-III) identified in endothelial cells. Regulation of eNOS activity occurs through phosphorylation at multiple sites. Phosphorylation of Ser-633 (mouse Ser-632) in the FMN binding domain increases eNOS activity and may be important for the maintenance of NO synthesis after initial activation by Ca2+ flux and Ser-1177 phosphorylation.\nAntigen Affinity Purified\nICC, IHC, WB\nThis antibody was generated from a recombinant mouse eNOS protein that included amino acids residues in the C-terminal region. This sequence is conserved in human and rat eNOS, and has low homology to other NOS family member\nHuman, Mouse, Rat\nStorage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.\nPBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol\nThe antibody detects a 140 kDa* protein corresponding to eNOS on SDS-PAGE immunoblots of human umbilical vein endothelial cells.\nWestern blots performed on each lot.\nFor research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.\nAfter date of receipt, stable for at least 1 year at -20°C.", "domain": "chemistry", "round": 3} +{"url": "https://autoadditives.net/blog/exploring-the-importance-of-diesel-engine-fuel-system-additives/", "date": "2024-04-21T23:57:49Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712296818067.32/warc/CC-MAIN-20240421225303-20240422015303-00274.warc.gz", "language_score": 0.9575644135475159, "token_count": 903, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__204323545", "lang": "en", "text": "Understanding the Significance of Fuel System Additives for Diesel Engines\nAs the automotive industry continues to evolve, the need for efficient and high-performing engines becomes more critical. One of the key elements that contribute to the overall performance and longevity of diesel engines is the use of fuel system additives. Despite their importance, not many automotive additive manufacturers produce these crucial components, leading to a gap in the market and a potential lack of understanding among vehicle owners about their benefits.\nFuel system additives for diesel engines are specially formulated compounds designed to enhance the performance and efficiency of these engines. They work by cleaning, protecting, and lubricating the engine’s fuel system, thereby ensuring optimal performance and a longer lifespan for the engine. However, their use is not as widespread as it should be, primarily because of the lack of adequate production by manufacturers.\nWith the growing emphasis on vehicle maintenance and the increasing understanding of the importance of fuel additives, it is crucial to delve deeper into this topic. This article aims to shed light on what fuel system additives for diesel engines are, why they are necessary, and under what symptoms they should be used. Additionally, it will also explore when these additives can replace repairs and visits to the service station, and which brands offer the best quality fuel system additives for diesel engines.\nUnderstanding these aspects can help vehicle owners make informed decisions about their engine maintenance, leading to improved performance, reduced repair costs, and a longer engine lifespan. So, whether you are a seasoned vehicle owner or a new entrant into the world of diesel engines, this comprehensive guide will provide you with valuable insights into the world of fuel system additives.\nDelving into the World of Fuel System Additives for Diesel Engines\nNot Many Automotive Additive Manufacturers Produce Fuel System Additives for Diesel Engine\nDespite the proven benefits of fuel system additives for diesel engines, there is a surprising lack of production by many automotive additive manufacturers. This could be attributed to several factors, including the complexity of the formulation process, the lack of awareness among consumers, and the perceived high cost of these additives. However, this lack of production does not diminish the importance of these additives in maintaining and enhancing the performance of diesel engines.\nWhat are Fuel System Additives for Diesel Engine\nFuel system additives for diesel engines are specially designed compounds that are added to the fuel. They serve multiple purposes, from cleaning the fuel system to improving fuel economy and reducing emissions. These additives are designed to remove deposits and other contaminants that can build up in the fuel system over time. They also help to lubricate the engine parts, reducing wear and tear and extending the engine’s lifespan.\nWhy They are So Necessary and At What Symptoms They Should be Used\nFuel system additives for diesel engines are crucial for several reasons. They help to maintain the engine’s performance, improve fuel efficiency, reduce emissions, and extend the engine’s lifespan. The need for these additives becomes evident through certain symptoms such as decreased fuel efficiency, increased emissions, poor engine performance, and frequent engine problems.\nWhen these symptoms appear, it is often an indication that the fuel system is clogged with deposits and other contaminants. Using fuel system additives can help to clean the system and restore the engine’s performance.\nWhen They Can Replace Repairs and Visits to the Service Station\nRegular use of fuel system additives for diesel engines can often prevent the need for costly repairs and frequent visits to the service station. By keeping the fuel system clean and functioning efficiently, these additives can prevent common engine problems and help to maintain the engine’s performance. However, they should not be seen as a substitute for regular maintenance and servicing. Rather, they should be used as part of a comprehensive maintenance plan to keep the engine in top condition.\nWhich Brands Offer the Best Quality Fuel System Additives for Diesel Engine\nWhile there are not many manufacturers producing fuel system additives for diesel engines, a few brands stand out for their quality and effectiveness. These include Lucas, Atomium, Stanadyne, and Power Service. These brands are well-known in the automotive industry for their high-quality additives that deliver on their promises. They offer a range of fuel system additives designed to meet the needs of different diesel engines and to address various performance issues.\nIn an ocean of manufacturers it is not easy to find the pearl of quality. Our manufacturer ranking will help you do just that.\nGood luck on the road!", "domain": "chemistry", "round": 3} +{"url": "https://www.prospecbio.com/mpneumoniae_p116", "date": "2023-09-24T00:13:26Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233506539.13/warc/CC-MAIN-20230923231031-20230924021031-00390.warc.gz", "language_score": 0.9307735562324524, "token_count": 317, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__63748948", "lang": "en", "text": "Mycoplasma pneumonia is part of the atypical pneumonia subtype which is caused by the bacteria M. pneumoniae. Mycoplasma pneumonia affects individuals younger than 40. It makes up 15 - 50% of all pneumonia cases in adults and especially in school-aged children. People at great risk for mycoplasma pneumonia comprise of those living or working in busy areas such as schools and homeless shelters, although many people who contract mycoplasma pneumonia have no identifiable risk factor. P1, P30, and P116 of mycoplasma pneumonia membrane proteins have been recognized as adhensive factors, P1 is considered as a main adhension protein of the organism colonization.\nThe Recombinant Mycoplasma Pneumoniae P116 was expressed in E. coli having an Mw of 116 kDa. P116 is fused to a His-Tag.\nThe recombinant fusion protein was purified by GSH affinity chromatography technique.\nStreile filtered colorless solution.\nMycoplasma Pneumoniae P116 is formulated in 1xPBS, pH 7.4 and 25mM arginine.\nUpon arrival, Store at -20°C.\nPlease prevent freeze-thaw cycles.\nGreater than 95% as determined by 10% PAGE (Coomassie staining).\nProSpecs products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.", "domain": "chemistry", "round": 3} +{"url": "https://passionlifelovehealth.com/trail-stages-involved-in-the-clinical-research/", "date": "2020-02-26T09:58:45Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-10/segments/1581875146341.16/warc/CC-MAIN-20200226084902-20200226114902-00334.warc.gz", "language_score": 0.9434011578559875, "token_count": 608, "dump": "CC-MAIN-2020-10", "global_id": "webtext-fineweb__CC-MAIN-2020-10__0__129699230", "lang": "en", "text": "Before the drug is ready for commercial use, this must involve various trials and tests. The drug researchers must analyze whether the drug is safe to use. The researchers must provide details of the drug’s toxicity, efficacy, pharmacokinetics, and safety reports. There are two types of preclinical research. They are\n- In vitro – Contacted in a test tube or cell culture\n- In vivo – Contacted in animal\nNeeds for preclinical research\nThe preclinical research is not a very high process but this must explain a lot of information like dosing and toxicity levels. Some of the basic things are required to perform preclinical research. They are\n- Study conduct\n- Operating procedures\n- Study reports\n- System of quality assurance for each study\n- Written protocols\nPhase 0 clinical trial\nThe phase 0 involves the first-in-human trial which is based on the FDA guidelines. This is also called as human microdose studies. This process involves single sub-therapeutic doses given to 15 subjects and gets the pharmacokinetic data. The phase 0 is performed by the pharmaceutical companies to decide which of the drug candidates has suitable pharmacokinetic parameters in humans.\nPhase 1 clinical trials\nThe phase 1 clinical trial is the first stage of drug testing with a small number of healthy human subjects. Patients are used to testing the mechanism and effects of the drug. Pharmacodynamics is also measured if possible. The single ascending dose is used to study the safety and tolerability of the drug. This is followed by the multiple ascending doses. Both are a similar process but the only difference is the number of testing subjects may vary. The only aim of these testing is to find out the safety and tolerability.\nPhase 2 clinical trials\nPhase 2 is performed on a large group of parents and the main aim of this phase is to assess the efficiency of the drug. Also, follow phase 1 safety measures. The phase 2 process is mainly designed based on the compound’s mechanism of action.\nPhase 3 clinical trials\nThe phase 3 clinical trials provide the long term safety data. The phase 3 trial is designed to investigate deeply about the efficiency and safety of the new drugs for more than 12 months. This test is performed under hundreds of patients and watch more closely than phase 1 and 2. This test is conducted with out-patient which helps to analyze each and every change. Phase 3 reports are submitted to the authorities to get approval.\nPhase 4 clinical trials\nThe phase 4 clinical trial is also called a post-marketing surveillance trial. This process involves safety surveillance and ongoing approval support after drug approval. This phase is designed to find-out any long-term side effects or any other toxicity. This phase is performed by some of the competitive companies for their marketing purpose.\nAfter all these trials and preclinical research, the researchers will review the testing and decide whether the drug is suitable for commercial use. After getting approval from the authorities, the drug is used for commercial purpose.", "domain": "chemistry", "round": 3} +{"url": "https://refiningcommunity.com/fccu-process-fundamentals/", "date": "2019-04-24T16:25:44Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-18/segments/1555578650225.76/warc/CC-MAIN-20190424154437-20190424180437-00482.warc.gz", "language_score": 0.8881901502609253, "token_count": 379, "dump": "CC-MAIN-2019-18", "global_id": "webtext-fineweb__CC-MAIN-2019-18__0__197804904", "lang": "en", "text": "See Pricing and Locations\nThe FCCU is no longer just a fuels producer but is producing petrochemical feedstocks, pretreating tar sands and producing biofuels.\nThe FCCU can change operations from the production of large volumes of gasoline blending components (up to 70 volume percent of the pool), to the production of large volumes of diesel blending components (up to 40 volume percent of the pool). The FCCU also produces approximately 110 barrels of product for every 100 barrels of feed. With this range of demonstrated flexibility and volume expansion, the FCCU is one of the most valuable process units in the refinery.\nYou Will Learn\nIncrease awareness of process fundamentals and operating principles for a broader understanding of the various FCC, RFCC and High Olefin FCC (HOFCC) unit process design differences, operating flexibilities and potential equipment revamp opportunities for more operating mode flexibility and future process development.\n- Introduction to the FCCU\n- Process Flow\n- FCCU Process Differences\n- Key Equipment\n- Cracking Reactions and Chemistry\n- Catalyst Components and Function\n- Pressure Balance\n- Heat Balance Effects\n- Feed Properties and Operating Variables\n- Understanding E-Cat Analyses and Catalyst Testing\n- Fluidization Issues\n- Future FCCU Technology Development and Operation\n- High Olefin FCCU\n- FCCU & Petrochemical Integration\n- New FCCU Processes\nWho Should Attend\nUnit operators and supervisors, refinery plant engineers, technical service and process engineers, both experienced and new to the FCC.\nFCC equipment and process licensors, and service providers who want a better understanding of the FCC process can also benefit.\nAn understanding of refining processes and petroleum refinery terminology is expected, having some experience with the FCC unit is helpful.\nDate: 30 Sept.-1 Oct. 2019\nPrice: $1,100.00 (USD)", "domain": "chemistry", "round": 3} +{"url": "http://rrdredlatina.info/sale/26867-Carbon-dating-fossils-accuracy.html", "date": "2019-03-19T10:08:27Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-13/segments/1552912201953.19/warc/CC-MAIN-20190319093341-20190319115341-00454.warc.gz", "language_score": 0.922918438911438, "token_count": 480, "dump": "CC-MAIN-2019-13", "global_id": "webtext-fineweb__CC-MAIN-2019-13__0__148599239", "lang": "en", "text": "ave questioned the accuracy of this method. These second types of radiometric dating, like carbon dating, it is used to “prove” the age of fossils and is\nHere of some of the well-tested methods of dating used in the study of early humans: Potassium-argon dating, Argon-argon dating, Carbon Dating Rocks and Fossils\nScientists attempt to check the accuracy of carbon dating by comparing the assumptions used in radiometric dating put the for dating fossils over\n1/13/2012How Carbon-14 has been used to date decontaminated dinosaur bones to between 22,000 and 39,000 years before Carbon-14 Dating Fossils - Duration: 28\nThey then use potassium argon, or other methods, and date the fossils again. They do this many times, 30,000 year limit to Carbon dating.\nCarbon dating. Detail of the tzi There is a small amount of radioactive carbon-14 in all living organisms because it enters the food chain. Once an organism\nRadiometric dating is a technique used to date materials using known decay rates. Are radiometric dating methods accurate?\nIs Carbon Dating Reliable? Responses from people who know about this field.\nAnswers to Creationist Attacks on Carbon-14 Dating; Answers to Creationist Attacks on Carbon-14 Dating. ‹ Are There Human Fossils in the for\nFor radiocarbon dating to be possible, This is taken up by plants through photosynthesis. Because the carbon present in a plant comes from the atmosphere in\n/31/1990Carbon dating is unreliable for objects older than about 30,000 years, but uranium-thorium dating may be possible for objects up to half a million years\nRadiocarbon dating lab Beta Analytic, based in Miami, (AMS) technology, which gives the most advanced precision and accuracy for Carbon-14 measurements.\nCarbon-14 dating is something that you hear about in the news all the time. Find out how carbon-14 dating works and why carbon-14 dating is so accurate!\nThe carbon clock is getting reset. Climate records from a Japanese lake are set to improve the accuracy of the dating technique, which could help to shed light on archaeological mysteries such as why Neanderthals became extinct. Carbon dating is used to work out the age of organic material — in", "domain": "chemistry", "round": 3} +{"url": "https://yves-rocher.hk/en/products/hc-nutrition-shampoo-300ml", "date": "2022-01-26T17:30:08Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-05/segments/1642320304959.80/warc/CC-MAIN-20220126162115-20220126192115-00129.warc.gz", "language_score": 0.6931923627853394, "token_count": 335, "dump": "CC-MAIN-2022-05", "global_id": "webtext-fineweb__CC-MAIN-2022-05__0__235505705", "lang": "en", "text": "Nutrition Shampoo 300ml\nRich in essential fatty acids, this avocado oil shampoo gently cleans and restores the hair to make it soft and silky. The shampoo provides the crucial nutrients it needs to achieve a natural lipid balance.\nMore than 98% of ingredients from natural origin and a botanical-based cleansing base\nOur Botanical Beauty® researchers have crafted the perfect combination of agave fructans that double microcirculation* for a healthy scalp and avocado oil that's armed with essential fatty acids. It replenishes the hair's missing lipids so it's intensely and sustainably nourished from the roots to the ends.\nApply on wet hair. Massage into the scalp. Rinse.\n*Test in vitro\nAQUA/WATER/EAU • SODIUM LAURETH SULFATE • COCAMIDOPROPYL BETAINE • COCAMIDE MIPA • GLYCOL DISTEARATE • PEG-7 GLYCERYL COCOATE • SODIUM CHLORIDE • PERSEA GRATISSIMA (AVOCADO) OIL • SODIUM BENZOATE • PARFUM/FRAGRANCE • CITRIC ACID • GUAR HYDROXYPROPYLTRIMONIUM CHLORIDE • FRUCTOOLIGOSACCHARIDES • INULIN • PANTHENOL • TOCOPHERYL ACETATE • SALICYLIC ACID • BENZYL ALCOHOL • LIMONENE", "domain": "chemistry", "round": 3} +{"url": "https://dokumen.tips/documents/southeastern-branch-of-the-american-society-for-web-view-there-is-a-microscopic.html", "date": "2021-06-16T01:45:03Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-25/segments/1623487621699.22/warc/CC-MAIN-20210616001810-20210616031810-00363.warc.gz", "language_score": 0.9313768148422241, "token_count": 456, "dump": "CC-MAIN-2021-25", "global_id": "webtext-fineweb__CC-MAIN-2021-25__0__158036436", "lang": "en", "text": "There is a microscopic world of organism everywhere on Earth\nLouis Pasteur1, Lazzaro Spallanzani2, and Antonie van Leeuwenhoek3\n1 École nationale supérieure des Beaux-Arts; 2 University of Reggio, Reggio, Italy; and 3 van Leeuwenhoek shop, Delf, Holland.\nAir, water and dirt contain biological components that can transform materia, generally producing biological substances such as alcohols, ammonia, acetates, etc. Previous data have shown that materia contained in these Earth’s elements can produce several human diseases, which can multiply in several organisms and disperse to other ones, and that they can be eliminated by simple procedures of filtration and heating. These observations suggest that these essential elements of Earth could host living organism that cannot be seen by the naked eye. e In these work we use a new method to analyze the microscopy world constituting these three elements of Earth with the goal of identifying their components, which could be constitudes by living microscopic organism besides common inorganic and organic materia. In our shop at Delf, we developed a series of lenses that allow the amplification of small particules from different sources. Exposition of the material to be studied under a white light with an intensity of a candle allowed the observation using a series of lenses of several creatures with cyllindrical, circular, spring and irregular shapes that we named initially animalcules (see figure). Some of this forms showed autonomal movement. Some of them can multiply in solid and liquid and have the potential of producing alcohol. Also, similar but bigger animalcules can be observed in human blood, which have the capacity of destroying other animalcules, we suggest that they could be a system of protection for potential diseases. Our results indicated that microscopy creatures can be found in diverse Earth and human sources. Such forms of life are microscopic and have the capacity for transforming biological material as well as for destroying other microscopic forms of life.\nCE disclosure: Mr Spallanzani received payments from a monastery at Reggio. Mr Pasteur and van Leeuwenhoek has two patent pending on production of alcohol and a microscope, respectively.", "domain": "chemistry", "round": 3} +{"url": "https://www.antikoerper-online.de/abstract/Acylglycerol+Kinase+(AGK)+ELISA+Kit/", "date": "2018-06-18T06:05:04Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-26/segments/1529267860089.11/warc/CC-MAIN-20180618051104-20180618071104-00206.warc.gz", "language_score": 0.7251130938529968, "token_count": 762, "dump": "CC-MAIN-2018-26", "global_id": "webtext-fineweb__CC-MAIN-2018-26__0__238478572", "lang": "en", "text": "Use your antibodies-online credentials, if available.\nKeine Produkte auf Ihrer Vergleichsliste.\nIhr Warenkorb ist leer.\nThe protein encoded by AGK is a mitochondrial membrane protein involved in lipid and glycerolipid metabolism. Zusätzlich bieten wir Ihnen Acylglycerol Kinase Antikörper (36) und Acylglycerol Kinase Proteine (8) und viele weitere Produktgruppen zu diesem Protein an.\nShowing 1 out of 5 products:\nHuman Acylglycerol Kinase ELISA Kit für Sandwich ELISA - ABIN421826\nAbu El-Asrar, Mohammad, Nawaz, Siddiquei, Kangave, Opdenakker: Expression of lysophosphatidic acid, autotaxin and acylglycerol kinase as biomarkers in diabetic retinopathy. in Acta diabetologica 2013\nThe dual function of AGK as lipid kinase and constituent of the TIM22 complex reveals that disturbances in both phospholipid metabolism and mitochondrial protein biogenesis contribute to the pathogenesis of Sengers syndrome.\nIdentify AGK as a bona fide subunit of TIM22 providing an exciting and unexpected link between mitochondrial protein import and Sengers syndrome.\nAcylglycerol kinase functions as an oncogene (zeige RAB1A ELISA Kits) and an unfavorable prognostic marker for human gliomas.\nWe showed that AGK was over-expressed in cervical cancer cell lines and clinical tissues, and over-expression of AGK was associated with poor survival outcomes of early-stage CSCC (zeige CYP11A1 ELISA Kits) patients. AGK can be used as an independent prognostic marker for early-stage CSCC (zeige CYP11A1 ELISA Kits).\nData suggest that acylglycerol kinase (AGK) has potential as a prognostic factor for overall survival in nasopharyngeal carcinoma (NPC (zeige NPC1 ELISA Kits)).\nAGK promotes the proliferation and cell cycle progression of oral squamous cell carcinoma.\nmiR (zeige MLXIP ELISA Kits)-194 could reduce the phosphoinositide 3-kinase (PI3K (zeige PIK3CA ELISA Kits))/AKT (zeige AKT1 ELISA Kits)/FoxO3a (zeige FOXO3 ELISA Kits) signaling pathway by suppressing acylglycerol kinase (AGK) directly.\nfindings provide new evidence that AGK plays an important role in promoting angiogenesis and providing resistance to apoptosis in hepatocellular carcinoma\ncompare our findings to those in 21 previously reported AGK mutation-positive Sengers patients, confirming that Sengers syndrome is a clinically recognisable disorder of mitochondrial energy metabolism\nAGK promotes cell proliferation and tumorigenicity in breast cancer via suppression of the FOXO1 (zeige FOXO1 ELISA Kits).\nThe protein encoded by this gene is a mitochondrial membrane protein involved in lipid and glycerolipid metabolism. The encoded protein is a lipid kinase that catalyzes the formation of phosphatidic and lysophosphatidic acids. Defects in this gene have been associated with mitochondrial DNA depletion syndrome 10.\n, acylglycerol kinase, mitochondrial-like\n, acylglycerol kinase, mitochondrial\n, multi-substrate lipid kinase\n, multiple substrate lipid kinase", "domain": "chemistry", "round": 3} +{"url": "https://www.thermofisher.com/antibody/product/VPS36-Antibody-Polyclonal/PA5-30611", "date": "2017-04-23T10:12:35Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-17/segments/1492917118519.29/warc/CC-MAIN-20170423031158-00348-ip-10-145-167-34.ec2.internal.warc.gz", "language_score": 0.7012733221054077, "token_count": 399, "dump": "CC-MAIN-2017-17", "global_id": "webtext-fineweb__CC-MAIN-2017-17__0__194452256", "lang": "en", "text": "|Tested species reactivity||Human|\n|Host / Isotype||Rabbit / IgG|\n|Immunogen||Recombinant protein fragment corresponding to a region within amino acids 70 and 268 of Human VPS36|\n|Purification||Antigen affinity chromatography|\n|Storage buffer||0.1M tris glycine, pH 7, with 20% glycerol|\n|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|\n|Tested Applications||Dilution *|\n|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|\n|Western Blot (WB)||1:500-1:3000|\n* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.\nPA5-30611 targets VPS36 in IHC (P) and WB applications and shows reactivity with Human samples.\nThe PA5-30611 immunogen is recombinant protein fragment corresponding to a region within amino acids 70 and 268 of Human VPS36.\nVPS36, VPS22 (SNF8; MIM 610904), and VPS25 (MIM 610907) form ESCRT-II (endosomal sorting complex required for transport II), a complex involved in endocytosis of ubiquitinated membrane proteins. VPS36, VPS22, and VPS25 are also associated in a multiprotein complex with RNA polymerase II elongation factor (ELL; MIM 600284) (Slagsvold et al., 2005 [PubMed 15755741]; Kamura et al., 2001 [PubMed 11278625]).\nFor Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.", "domain": "chemistry", "round": 3} +{"url": "https://bemlay.com/debate-carbon-dating.html", "date": "2021-02-27T13:03:31Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-10/segments/1614178358956.39/warc/CC-MAIN-20210227114444-20210227144444-00632.warc.gz", "language_score": 0.9432446360588074, "token_count": 878, "dump": "CC-MAIN-2021-10", "global_id": "webtext-fineweb__CC-MAIN-2021-10__0__37433230", "lang": "en", "text": "Radiocarbon dating can easily establish that humans have been on the earth for over twenty thousand years, at least twice as long as creationists are willing to. This topic of debate among christians over the nosams facility. The Shroud of Turin, a burial shroud, might date from the Roman era. According to the IAA, radiocarbon dating puts this papyrus in the seventh century BCE. Carbon-dating of an ancient beam from a Guatemalan temple may help end a century-long debate about the Mayan calendar, say.\nHigh carbon dioxide could suppress cooling clouds, debate carbon dating model warns · Democrats press military on. During the recent debate between Ken Ham and Bill Nye, the young. Carbon-14 measurements from stalagmites takes carbon dating back as far debate carbon dating it can. Radiometric Dating and the Bill Nye Debate. Santorini Eruption Radiocarbon Dated to 1627-1600 B.C., Science, Vol 312 (28.\nEver wondered. Beneficial how old. Theres been a lot of debate around the issue of Bible chronology. Since theres very little 13C, well ignore it in this discussion of dating. Radiocarbon dating is a method for determining the age of an object containing organic material by using the properties of radiocarbon, a radioactive isotope of. Carbon dating has been used since the 1940s to determine the ages. Scriptural prophecy settles the debate!.\nEngland and debate carbon dating United States using carbon-14 dating techniques, the. Does joey hook up with janice contend that radiocarbon dating is. A recent study into carbon dating may reset the archaeological timeline, adding fuel to an ongoing debate as to whether King David ruled over.\nIve been wondering lately debate carbon dating Carbon Dating. Despite the name. There has been much debate about the age of The Shroud of Turin. Akrotiri and nearby sites, including an olive tree buried by the erup- tion, pointed to a date more than 100 years earlier, debate carbon dating the.\nThats understandable, given the image that surrounds the method. By the debate carbon dating 1960s, most of the major radiometric dating techniques now febate use had been tested and their general limitations were known.\nThough it was carbon-dated to somewhere between debate carbon dating seventh and. These were dated increasingly through the use of carbon dating (also. Universe by Design: Problems with the Big Bang Big Bang Explanations Fall Flat Radiometric Dating The worst online dating sites Radiometric Dating and Proof Billion-Fold.\nDating based on the radioactive decay of 14C is essential to many fields. Radiocarbon dating has become a standard dating method dating rock strata archaeology almost. By Mikayla. The other method involves radiocarbon dating. There has been much debate for several decades among scholars.\nDating the Birth of Human Cells—Carbon 14 Runs Rings around Competition. The earliest experiments in radiocarbon dating were done on ancient material from Egypt. But since some have refused to believe the bishops findings, or the 1988 carbon dating debats the eebate was from the medieval, not the.\nCarbon released from burning fossil fuels will jeopardize the effectiveness of. All reference frames. Hey, and then be applied in a secondary school revision resource for scientists use carbon 14 to measure the debate radiometric dating. Debating Christianity and Religion - A debate forum for people of all. Think you understand what online dating results did stimulate debate.\nIn some cases, the latter ratio appears to be a much debate carbon dating accurate debate carbon dating of age than the customary method of carbon dating, the scientists. Their responses are. Radiocarbon dating has become a staple method debate carbon dating corroborating dates of.\nScientific American is the essential guide to the most awe-inspiring advances in science and technology, explaining how they change our.\nDating, also called radiocarbon dating organic. The dates given for Rapa Nui attract particular debate as they have debate carbon dating used ddbate. Among several radioactive dating methods, the radiocarbon (C-14) dating method. The upper anchor is in the 12th century BCE, represented by the well-established correlations.", "domain": "chemistry", "round": 3} +{"url": "https://www.amtaorg.com/membrane-biofilm-reactor-for-nitrate-and-perchlorate-treatment", "date": "2024-04-20T03:12:04Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712296817474.31/warc/CC-MAIN-20240420025340-20240420055340-00828.warc.gz", "language_score": 0.9047864675521851, "token_count": 288, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__170542808", "lang": "en", "text": "Research was conducted on a pilot-scale drinking water treatment plant system utilizing a membrane biofilm reactor (MBfR) for treatment of nitrate and perchlorate where the MBfR uses anaerobic autotrophic biodegradation for the complete destruction of nitrate and perchlorate. The purpose of the study was to demonstrate the feasibility of MBfR technology, evaluate process monitoring and control parameters to optimize performance, and estimate full-scale technology life cycle costs compared to conventional treatment. During steady state, total nitrogen was reduced from an influent average of 9.0 mg-N/L to an average of about 0.12 mg-N/L with the factors controlling performance being influent flow rate and recycle flow rate. The treatment objective goal for perchlorate was not met in the study, but was consistently removed. While the MBfR is effective for nitrate, perchlorate reduction was significant but not complete.\nThis presentation is available to AMTA Members only.\n- Jennifer Smith\n- CDM Smith Inc.\n- AWWA/AMTA Membrane Technology Conference, Las Vegas, NV\n- AWWA/AMTA Membrane Technology Conference\n- Biofilm Reactor, Nitrate, Perchlorate", "domain": "chemistry", "round": 3} +{"url": "http://www.bristol.ac.uk/chemistry/synthesis-cdt/programme/themes/natural-product-chemistry/", "date": "2019-10-17T13:04:58Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-43/segments/1570986675316.51/warc/CC-MAIN-20191017122657-20191017150157-00387.warc.gz", "language_score": 0.838890790939331, "token_count": 283, "dump": "CC-MAIN-2019-43", "global_id": "webtext-fineweb__CC-MAIN-2019-43__0__100512088", "lang": "en", "text": "Natural product chemistry\nBiosynthesis of thiomarinol A and related metabolites of Pseudoalteromonas sp. SANK 73390\nAnnabel C. Murphy, Shu-Shan Gao, Li-Chen Han, Simon Carobene, Daisuke Fukuda, Zhongshu Song, Joanne Hothersall, Russell J. Cox, John Crosby, Matthew P. Crump, Christopher M. Thomas, Christine L. Willis, Thomas J. Simpson; Chem. Sci, 2014, 5, 397-402\nThe biosynthesis of the mixed PKS-FAS-NRPS hybrid antibiotic thiomarinol A was investigated using feeding studies to both wild type and mutant strains of the marine bacterium Pseudoalteromonas. Particularly interesting features of the pathway include assembly of the 8-hydroxyoctanoic acid side-chain via chain extension of a C4-precursor (4-hydroxybutyrate), and construction of the pyrrothine unit from cysteine via (HolA-D, F-H) prior to intact incorporation into thiomarinol (catalysed by TmlU). A series of thiomarinol-related and other minor metabolites have been isolated from wild-type and mutant strains. The results of these investigations are rationalised in terms of the overall biosynthetic pathway.", "domain": "chemistry", "round": 3} +{"url": "https://experts.unthsc.edu/en/publications/cd38cyclic-adp-ribose-regulates-astrocyte-calcium-signaling-impli", "date": "2023-02-08T14:54:22Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-06/segments/1674764500813.58/warc/CC-MAIN-20230208123621-20230208153621-00237.warc.gz", "language_score": 0.8769776821136475, "token_count": 538, "dump": "CC-MAIN-2023-06", "global_id": "webtext-fineweb__CC-MAIN-2023-06__0__237268915", "lang": "en", "text": "CD38 is a 45-kD ectoenzyme involved in the synthesis of potent calcium (Ca2+)-mobilizing agents, cyclic adenosine diphosphate-ribose (cADPR), and nicotinic acid adenine dinucleotide phosphate (NAADP+). In HIV-1-infected patients, increased CD38 expression on CD8+ T cells is linked to immune system activation and progression of HIV-1 infection. However, the role of CD38 upregulation in astrocyte function and HIV-1-associated dementia (HAD-now called HAND: HIV-1-associated neurocognitive disorder) neuropathogenesis is unclear. To these ends, we used interleukin (IL)-1β and HIV-1gp120 to activate primary human astrocytes and measured CD38 expression using real-time polymerase chain reaction and CD38 function by ADP-ribosyl cyclase activity. We also determined cADPR-mediated changes in single-cell intracellular Ca2+ transients in activated astrocytes in presence or absence of ethylene glycol tetraacetic acid. CD38 levels were downregulated using CD38 small-interfering RNA (siRNA) and intracellular Ca2+ concentration ([Ca2+]i) was measured. We previously reported a ∼20-fold rise in CD38 messenger RNA levels in IL-1β-activated astrocytes. We extend this observation and report that HIV-1gp120 potentiated CD38 expression in a dose-dependent manner and also increased CD38 enzyme activity in control and IL-1β-activated astrocytes. We demonstrate higher cADPR levels in IL-1β-activated astrocytes with a corresponding rise in [Ca2+]i upon cADPR application and its non-hydrolysable analog, 3-deaza-cADPR. In activated astrocytes, pre-treatment with the cADPR-specific antagonist 8-Br-cADPR and CD38 siRNA transfection returned elevated [Ca2+]i to baseline, thus confirming a CD38-cADPR specific response. These data are important for unraveling the mechanisms underlying the role of astrocyte-CD38 in HAD and have broader implications in other inflammatory diseases involving astrocyte activation and CD38 dysregulation.\n- HIV-1-associated dementia", "domain": "chemistry", "round": 3} +{"url": "https://scholarworks.wm.edu/honorstheses/2037/", "date": "2023-09-22T11:55:51Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233506399.24/warc/CC-MAIN-20230922102329-20230922132329-00246.warc.gz", "language_score": 0.9079471826553345, "token_count": 782, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__197169250", "lang": "en", "text": "Date Thesis Awarded\nHonors Thesis -- Access Restricted On-Campus Only\nBachelors of Science (BS)\nShantà D. Hinton\nLizabeth A. Allsion\nMark S. Forsyth\nKristin L. Wustholz\nThe pseudophosphatase MK-STYX (mitogen activated protein kinase phosphoserine/threonine/tyrosine binding protein) is a member of the MAPK phosphatase (MKP) family. However, MK-STYX has the amino acid sequence FSX5R in its active site instead of the sequence HCX5R present in other protein tyrosine phosphatases. The replacement of the critical cysteine residue with a serine renders MK-STYX catalytically inactive as a phosphatase. The Hinton Lab previously reported that MK-STYX interacts with the RNA binding protein Ras-GTPase SH3 domain binding protein-1 (G3BP1) in the stress response pathway. During the stress response, mRNA translation is halted, and stress granules, which are cytoplasmic aggregates of mRNA and mRNA binding proteins, are formed. G3BP1 serves as a major structural component of these stress granules. Additionally, microtubules and their associated proteins transport stress granule components to the correct places during the initial stages of assembly. Many proteins that move along microtubules to stress granules, including G3BP1, require the activity of two proteins: dynein and lysine deacetylase 6 (KDAC6). KDAC6 is responsible for facilitating the transport of ubiquitinylated proteins by dynein. Additionally, it regulates microtubule reorganization through the deacetylation of polymerized microtubules. Dynein motility and localization can be affected by several proteins and alteration of these two dynamics may affect stress granule formation. MK-STYX decreases stress granule assembly, however, it does so independently of G3BP1 phosphorylation status at serine 149 which has been reported to induce stress granule formation. Given the essential nature of G3BP1’s interaction with KDAC6 and dynein, we decided to investigate what effects if any that MK-STYX is having on the two proteins. Because KDAC6 deacetylase activity has been shown to affect stress granule assembly, we investigated whether MK-STYX influenced KDAC6 deacetylation. KDAC6 activity assay pilot studies indicate that KDAC6 deacetylase activity is unaffected by the presence of MK-STYX. To further understand the interaction between MK-STYX and dynein, we transfected HEK-293 cells with fluorophore conjugated constructs and studied their localization. Dynein appears to colocalize with MK-STYX. Additionally, dynein localizes to aggregates in the presence of MK-STYX. We have previously demonstrated that MK-STYX does not localize to G3BP1-induced stress granules, so these dynein aggregates may be a novel way of controlling dynein activity.\nReed, Quinton, \"Exploring MK-STYX's Interaction with KDAC6 and Dynein\" (2023). Undergraduate Honors Theses. William & Mary. Paper 2037.\nAvailable for download on Sunday, May 12, 2030\nOn-Campus Access Only", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/bak-antibody-no48a10-ab238515.html", "date": "2020-09-30T21:45:37Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-40/segments/1600402128649.98/warc/CC-MAIN-20200930204041-20200930234041-00625.warc.gz", "language_score": 0.7474693059921265, "token_count": 550, "dump": "CC-MAIN-2020-40", "global_id": "webtext-fineweb__CC-MAIN-2020-40__0__3616172", "lang": "en", "text": "Key features and details\n- Rabbit monoclonal [NO.48A10] to Bak\n- Suitable for: WB\n- Reacts with: Human\n- Isotype: IgG\nStorage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.\nStorage bufferpH: 7.30\nPreservative: 0.02% Sodium azide\nConstituents: PBS, 50% Glycerol\nConcentration information loading...\nOur Abpromise guarantee covers the use of ab238515 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\n|WB||1/500 - 1/2000. Predicted molecular weight: 23 kDa.|\nFunctionIn the presence of an appropriate stimulus, accelerates programmed cell death by binding to, and antagonizing the anti-apoptotic action of BCL2 or its adenovirus homolog E1B 19k protein. Low micromolar levels of zinc ions inhibit the promotion of apoptosis.\nTissue specificityExpressed in a wide variety of tissues, with highest levels in the heart and skeletal muscle.\nSequence similaritiesBelongs to the Bcl-2 family.\nDomainIntact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.\nCellular localizationMitochondrion membrane.\n- Information by UniProt\n- Apoptosis regulator BAK antibody\n- BAK antibody\n- BAK like antibody\nAll lanes : Anti-Bak antibody [NO.48A10] (ab238515) at 1/500 dilution\nLane 1 : HeLa (human epithelial cell line from cervix adenocarcinoma) cell lysate\nLane 2 : AGS cell lysate\nLysates/proteins at 25 µg per lane.\nAll lanes : HRP Goat Anti-Rabbit IgG (H+L)\nPredicted band size: 23 kDa\nBlocking buffer: 3% non-fat dry milk in TBST.\nTo our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.\nab238515 has not yet been referenced specifically in any publications.", "domain": "chemistry", "round": 3} +{"url": "https://keio.elsevierpure.com/en/publications/thrombopoietin-and-thrombin-induce-tyrosine-phosphorylation-of-va", "date": "2023-10-02T02:42:17Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233510942.97/warc/CC-MAIN-20231002001302-20231002031302-00723.warc.gz", "language_score": 0.9154216647148132, "token_count": 642, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__92021700", "lang": "en", "text": "Thrombopoietin has an essential role in megakaryopoiesis and thrombopoiesis. To investigate the signaling processes induced by thrombopoietin, we have employed human platelets and recently demonstrated that thrombopoietin induces rapid tyrosine phosphorylation of Jak-2, Tyk2, Shc, Stat3, Stat5, p12O(c-cbl) and other proteins in human platelets. Because the apparent molecular weight of a major tyrosine phosphorylated protein in platelets stimulated by thrombopoietin is approximately 85 to 95 kD, we examined the possibility that this could be Vav, a 95-kD proto-oncogene product. Specific antisera against Vav recognized the same 95 kD protein in lysates of Jurkat cells, which are known to express Vav, and platelets, indicating that platelets have Vav. Thrombopoietin induced rapid tyrosine phosphorylation of Vav in platelets without an elevation in cytosolic free calcium concentration or activation of protein kinase C. Vav was also tyrosine phosphorylated upon treatment of platelets with thrombin, collagen, or U46619, which activate phospholipase C, leading to an increased ionized calcium concentration and activation of protein kinase C. Ionomycin or phorbol 12-myristate 13-acetate (PMA) also induces tyrosine phosphorylation of Vav, suggesting that an increase in ionized calcium concentration or activation of protein kinase C may lead to phosphorylation of Vav. Thrombopoietin also induced tyrosine phosphorylation of Vav in FDCP-2 cells, genetically engineered to express human c-Mpl (FDCP-hMpl5). However, neither ionomycin nor PMA induced an increase in tyrosine phosphorylation of Vav in FDCP-hMpl5 cells, suggesting that the calcium and protein kinase C pathways of Vav phosphorylation may be unique to platelets. Further, Vav became incorporated into the Triton X-100 insoluble 10,000g sedimentable residue in an aggregation-dependent manner, suggesting that it may have a regulatory role in platelet cytoskeletal processes. Vav was constitutively associated with a 28-kD adapter protein, Grb2, which is also incorporated into the cytoskeleton in an aggregation dependent fashion. Lastly, we found that Vav is cleaved when there is activation of calpain, a protease that may have a role in postaggregation signaling processes. Our data suggest that thrombopoietin and other agonists may induce tyrosine phosphorylation of Vav by different mechanisms and Vav may also be involved in signaling during platelet aggregation by its redistribution to the cytoskeleton.\nASJC Scopus subject areas\n- Cell Biology", "domain": "chemistry", "round": 3} +{"url": "https://www.lsbio.com/antibodies/anti-uimc1-antibody-rap80-antibody-aa535-548-elisa-ihc-ihc-plus-ls-b7372/156520", "date": "2018-06-19T20:24:34Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-26/segments/1529267863119.34/warc/CC-MAIN-20180619193031-20180619213031-00501.warc.gz", "language_score": 0.7478668689727783, "token_count": 435, "dump": "CC-MAIN-2018-26", "global_id": "webtext-fineweb__CC-MAIN-2018-26__0__196441225", "lang": "en", "text": "Human UIMC1 / RAP80\n(tested or 100% immunogen sequence identity)\nDog (at least 90% immunogen sequence identity)\n- IHC - Paraffin (3.75 µg/ml)\n- Peptide Enzyme-Linked Immunosorbent Assay (1:32000)\nSee our complete line of Immunohistochemistry Reagents\nincluding antigen retrieval solutions, blocking agents\nABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.\nUIMC1 / RAP80 antibody was raised against synthetic peptide C-TRRQKEAKTKSDSG from an internal region of human UIMC1 / RAP80 (NP_057374.3). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset (100%); Dog (93%); Rabbit, Pig (86%).\n- Lyophilized - 100 µg - $145.00\nImmunizing peptide used to generate LS-B7372. Useful for pre-absorption and neutralization of the antibody's antigen binding site.\nHuman UIMC1 / RAP80.\nPeptide ELISA: antibody detection limit dilution 1:32000. Western blot: Preliminary experiments gave an approx 60 kDa band in Human Heart and Spleen lysates and in lysates of cell lines A431, HeLa and HepG2 after 0.3 ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 79.7 kDa according to NP_057374.3. The 60 kDa band was successfully blocked by incubation with the immunizing peptide.\nTris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide\nStore at -20°C. Avoid freeze-thaw cycles.\nFor research use only.\nThis antibody carries the LSBio 100% Guarantee.", "domain": "chemistry", "round": 3} +{"url": "https://www.budget101.com/tips-n-tricks/1859-drain-cleaner/", "date": "2023-03-23T07:53:31Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-14/segments/1679296945030.59/warc/CC-MAIN-20230323065609-20230323095609-00063.warc.gz", "language_score": 0.9236541390419006, "token_count": 269, "dump": "CC-MAIN-2023-14", "global_id": "webtext-fineweb__CC-MAIN-2023-14__0__277836634", "lang": "en", "text": "Combine the following and then slowly pour down the drain you wish to clean:\n1/2 cup salt\n1/8 cup cream of tartar\n1/2 cup baking soda\n6 cups boiling water\nLeave Overnight. In the morning, Flush with warm water for several minutes.\n2 thoughts on “Drain Cleaner”\nthis is a good recipe, but i would caution that the 6 cups boiling water is not a good idea if the drain pipes are plastic, as you could melt them or cause a sag or leak.\nTo avoid using chemicals, pour 2-4 quarts of hot water down the drain weekly to keep it open. Do not use boiling water if you have plastic drain pipes, as they may melt or warp.\nMy favorite is to pour 1 cup warm vinegar into drain and cover. Vinegar is a mild acid, and can be left in the drain indefinitely without damaging drain pipes, so leave it as long as you like before using the drain.\nIf you like the smell of vinegar, the odor will also freshen the smell of the drain.\nfor further clarification, if you have pvc pipes (as opposed to plastic, typically found in mass-manufactured homes)- you can use boiling water without issue.", "domain": "chemistry", "round": 3} +{"url": "https://jp.certara.com/publication/selection-of-alternative-cyp3a4-probe-substrates-for-clinical-drug-interaction-studies-using-in-vitro-data-and-in-vivo-simulation/", "date": "2023-05-30T04:11:22Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-23/segments/1685224645089.3/warc/CC-MAIN-20230530032334-20230530062334-00485.warc.gz", "language_score": 0.8806648850440979, "token_count": 559, "dump": "CC-MAIN-2023-23", "global_id": "webtext-fineweb__CC-MAIN-2023-23__0__84222281", "lang": "en", "text": "Understanding the potential for cytochrome P450-mediated drug-drug interactions (DDIs) is a critical step in the drug discovery process. DDIs of CYP3A4 are of particular importance because of the number of marketed drugs that are cleared by this enzyme. In response to studies that suggested the presence of several binding regions within the CYP3A4 active site, multiple probe substrates are often used for in vitro CYP3A4 DDI studies, including midazolam (the clinical standard), felodipine/nifedipine, and testosterone. However, the design of clinical CYP3A4 DDI studies may be confounded for cases such as 1-(2-hydroxy-2-methylpropyl)-N-[5-(7-methoxyquinolin-4-yloxy)pyridin-2-yl]-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide (AMG 458), with which testosterone is predicted to exhibit a clinically relevant DDI whereas midazolam and felodipine/nifedipine are not. To develop an appropriate path forward for such clinical DDI studies, the inhibition potency of 20 known inhibitors of CYP3A4 were measured in vitro using 8 clinically relevant CYP3A4 probe substrates and testosterone. Hierarchical clustering suggested four probe substrate clusters: testosterone; felodipine; midazolam, buspirone, quinidine, and sildenafil; and simvastatin, budesonide, and fluticasone. The in vivo sensitivities of six clinically relevant CYP3A4 probe substrates (buspirone, cyclosporine, nifedipine, quinidine, sildenafil, and simvastatin) were determined in relation to midazolam from literature DDI data. Buspirone, sildenafil, and simvastatin exhibited similar or greater sensitivity than midazolam to CYP3A4 inhibition in vivo. Finally, Simcyp® was used to predict the in vivo magnitude of CYP3A4 DDIs caused by AMG 458 using midazolam, sildenafil, simvastatin, and testosterone as probe substrates.\nSelection of Alternative CYP3A4 Probe Substrates for Clinical Drug Interaction Studies Using In Vitro Data and In Vivo Simulation", "domain": "chemistry", "round": 3} +{"url": "http://www.ph.nagasaki-u.ac.jp/lab/hygiene/publication/2015/2015ab/20151200ab.html", "date": "2018-12-09T20:44:20Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-51/segments/1544376823009.19/warc/CC-MAIN-20181209185547-20181209211547-00207.warc.gz", "language_score": 0.9306640625, "token_count": 438, "dump": "CC-MAIN-2018-51", "global_id": "webtext-fineweb__CC-MAIN-2018-51__0__38289215", "lang": "en", "text": "Synthesis and evaluation of a radioiodinated 4,6-diaryl-3-cyano-2-pyridinone derivative as a survivin targeting SPECT probe for tumor imaging\nSurvivin is overexpressed in most of the cancerous tissues but not in terminally differentiated normal tissues, making it an attractive target for diagnosis and therapy of various types of cancers. In this study, we aimed to develop 4,6-diaryl-3-cyano-2-pyridinone (DCP) derivatives, as novel cancer imaging probes that target survivin. Chloro and iodo analogs of DCP (CDCP and IDCP, respectively) were successfully synthesized by using a previously unreported carbon monoxide-free procedure. IDCP exhibited a slightly higher binding affinity for recombinant human survivin (Kd = 34 nM) than that of CDCP (Kd = 44 nM). Fluorescence staining indicated that both CDCP and IDCP showed high signals in MDA-MB-231 cells with high levels of survivin expression. Significantly low fluorescent signals were observed in MCF-10A cells, which showed low levels of survivin expression. [125I]IDCP was synthesized for the application of IDCP to single photon emission computed tomography (SPECT) imaging. Quantitative in vitro binding of [125I]IDCP in cell cultures showed results consistent to those observed after fluorescent staining. In vivo biodistribution studies in tumor-bearing mice demonstrated that the tumor uptake of [125I]IDCP increased gradually with time and was 0.65% injected dose per gram (% ID/g) at 180 min. The maximum tumor/blood and tumor/muscle ratio at 60 min were 0.87 and 2.27, respectively, indicating inadequate [125I]IDCP accumulation in tumors necessary for in vivo imaging. Although further structural modifications are necessary to improve pharmacokinetic properties of IDCP, this study demonstrates the feasibility of using the DCP backbone as a scaffold for the development of survivin-targeting tumor imaging probes.", "domain": "chemistry", "round": 3} +{"url": "https://borea.mnhn.fr/fr/effects-chlordecone-20-hydroxyecdysone-concentration-and-chitobiase-activity-decapod-crustacean", "date": "2023-03-23T15:30:28Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-14/segments/1679296945168.36/warc/CC-MAIN-20230323132026-20230323162026-00309.warc.gz", "language_score": 0.8766122460365295, "token_count": 504, "dump": "CC-MAIN-2023-14", "global_id": "webtext-fineweb__CC-MAIN-2023-14__0__5961634", "lang": "en", "text": "|Titre||Effects of chlordecone on 20-hydroxyecdysone concentration and chitobiase activity in a decapod crustacean, Macrobrachium rosenbergii|\n|Type de publication||Journal Article|\n|Year of Publication||2016|\n|Auteurs||Lafontaine, A, Gismondi, E, Boulangé-Lecomte, C, Gerraudie, P, Dodet, N, Campos, F, Lemoine, S, Lagadic, L, Thomé, J-P, Forget-Leray, J|\n|Mots-clés||20-Hydroxyecdysone, Chitobiase, Chlordecone, Endocrine Disruptors, Macrobrachium rosenbergii|\nChlordecone (CLD) is an organochlorine insecticide abundant in aquatic environment of the French West Indies. However, few studies have investigated its impact on freshwater invertebrates. WhereasCLD is suspected of inducingendocrine disruption,this work aimed to study the effects of environmentally relevant concentrations of CLD on the 20-hydroxyecdysone (20-HE) hormone concentration and on the chitobiase activity, both having key roles in the molting process of crustaceans. In addition, the bioaccumulation of CLD was measured in the muscle tissueof Macrobrachium rosenbergiito underline potential dose-response relationship. The results have shown that CLD was bioaccumulated in exposed organisms according to a trend to a dose-response relationship. Moreover, it was observed that CLD decreased the 20-HE concentration in exposed prawns when compared to control, whatever the duration of exposure, as well as it inhibited the chitobiase activity after 30 days of exposure. The present study indicates that CLD could interfere with molting process of M. rosenbergiiby disturbing the 20-HE concentration and the activity of chitobiase, suggesting consequences at the long term on the shrimp development. This study also confirmed that CLD could be an endocrine disruptor in decapod crustaceans, as it was already observed in vertebrates.", "domain": "chemistry", "round": 3} +{"url": "https://kymbooke.com/category/does-cbd-gummies-have-thc-2/", "date": "2023-02-02T11:56:01Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-06/segments/1674764500017.27/warc/CC-MAIN-20230202101933-20230202131933-00098.warc.gz", "language_score": 0.9344984292984009, "token_count": 285, "dump": "CC-MAIN-2023-06", "global_id": "webtext-fineweb__CC-MAIN-2023-06__0__161312980", "lang": "en", "text": "MODIFY 3/20 – NORML has create a declaration saying, to some extent, “Further, because COVID-19 is really an illness that is respiratory some people might wish to restrict or avoid their contact with combustive smoke — as this might place undue anxiety and pressure on the lungs. Alternate distribution products, such as for instance vaporizer heating products can somewhat mitigate smoke that is combustive, and undoubtedly, the utilization of edibles or tinctures can eradicate smoke visibility totally.”\nVaporization is an approach for avoiding irritating breathing toxins in cannabis smoke by warming cannabis to a heat where in actuality the psychoactive ingredients evaporate without producing combustion.\nLaboratory studies done by Ca NORML and MAPS are finding that vaporizers can effectively deliver cannabinoids while eliminating or drastically reducing other smoke toxins.\nLike tobacco, marijuana smoke look here contains toxins which are considered to be dangerous towards the respiratory system. Included in this will be the very carcinogenic polynuclear aromatic hydrocarbons, a prime suspect in cigarette-related cancers. These toxins are basically a byproduct of combustion, split through the pharmaceutically active the different parts of cannabis, referred to as cannabinoids, including THC. Even though there is not any evidence that marijuana smoking causes cancer tumors, chronic pot cigarette cigarette smokers have now been demonstrated to suffer an elevated danger of bronchitis and respiratory infections. Read More", "domain": "chemistry", "round": 3} +{"url": "https://pfascentral.org/policy/legislation-to-protect-public-health-and-the-environment-from-pfas", "date": "2022-12-10T05:50:21Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-49/segments/1669446711712.26/warc/CC-MAIN-20221210042021-20221210072021-00847.warc.gz", "language_score": 0.9447335004806519, "token_count": 348, "dump": "CC-MAIN-2022-49", "global_id": "webtext-fineweb__CC-MAIN-2022-49__0__252830370", "lang": "en", "text": "Legislation to Protect Public Health and the Environment from PFAS\nNovember 16, 2021\nAs the United States Senate Committee on Environment and Public Works moves forward with hearings to address the threat to human health and the environment posed by the class of chemical compounds known as poly- and per-fluoroalkyl substances (“PFAS”), the undersigned state attorneys general write to urge the Committee to pass legislation that ensures that our states’ most urgent needs are addressed. PFAS are associated with severe health effects, including cancer, thyroid disease, and liver damage. Our states are spending tens of millions of taxpayer dollars to protect our residents from PFAS by remediating PFAS contamination in drinking water, providing alternative drinking water supplies, testing the blood of residents of impacted communities, and determining the scope of contamination. The serious public health threats posed by PFAS contamination and the significant budgetary impacts incurred by our states in response call for swift Congressional action.\nWe urge the Committee to pass or build on the bi-partisan PFAS Action Act of 2021, H.R. 2467, passed by the U.S. House of Representatives on July 21st. The PFAS Action Act contains a number of provisions vital to protecting public health, including:\n- providing legal authority to compel responsible parties to cleanup PFAS contamination;\n- reducing exposure to and identifying PFAS contamination in air and water;\n- providing funding to address PFAS contamination in drinking water;\n- making medical screenings available to individuals that may have been exposed to elevated levels of PFAS; and\n- prohibiting the use of firefighting foam containing PFAS at federal facilities or by federal entities.\nRead the letter here.", "domain": "chemistry", "round": 3} +{"url": "https://www.antibodies-online.com/abstract/Fanconi+Anemia%2C+Complementation+Group+D2+(FANCD2)+ELISA+Kit/", "date": "2018-02-25T19:55:38Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-09/segments/1518891816912.94/warc/CC-MAIN-20180225190023-20180225210023-00002.warc.gz", "language_score": 0.8825913667678833, "token_count": 1912, "dump": "CC-MAIN-2018-09", "global_id": "webtext-fineweb__CC-MAIN-2018-09__0__55236956", "lang": "en", "text": "Use your antibodies-online credentials, if available.\nNo Products on your Comparison List.\nYour basket is empty.\nFind out more\nThe Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). Additionally we are shipping FANCD2 Antibodies (148) and and many more products for this protein.\nShowing 6 out of 10 products:\nWang, Wang, Qi: Identification of riboflavin: revealing different metabolic characteristics between Escherichia coli BL21(DE3) and MG1655. in FEMS microbiology letters 2015\nShow all 2 Pubmed References\nFANCD2 acts independently of previous S phases to promote alignment and segregation of acentric DNA produced by double-strand breaks.\nFancd2 has a role in DNA repair.\nstudy showed that FANCI (show FANCI ELISA Kits)-FANCD2 is required for replication-coupled DNA interstrand cross-link (ICL) repair in S phase; results show that multiple steps of the essential S-phase ICL repair mechanism fail when the Fanconi anemia (show PALB2 ELISA Kits) pathway is compromised\nThe Fanconi anemia protein FANCM (show FANCM ELISA Kits) is controlled by FANCD2 and the ATR (show ATR ELISA Kits)/ATM (show ATM ELISA Kits) pathways.\nsilkworm cells deficient for FA proteins FancD2 and FancM (show FANCM ELISA Kits) exhibit normal sensitivities to hydroxyurea (HU) and camptothecin (CPT (show DHDDS ELISA Kits))\nIt was shown that silkworm FancD2 is monoubiquitinated depending on FancI (show FANCI ELISA Kits) and FancL (show FANCL ELISA Kits), and stabilized on chromatin, following mitomycin C. Depletion of FancD2, FancI (show FANCI ELISA Kits) or FancL (show FANCL ELISA Kits) effected cell proliferation in the presence of mitomycin C.\nFANCD2 has a ubiquitination-independent role in countering endogenous levels of replication stress, a function that is critical for the maintenance of genomic stability.\nData suggest that FANCI (show FANCI ELISA Kits) and FANCD2 have partially non-overlapping and possibly even opposing roles during the replication stress response.\nFanconi anemia (show PALB2 ELISA Kits) FANCD2 and FANCI (show FANCI ELISA Kits) proteins regulate the nuclear dynamics of splicing factors, such as SF3B1.\nPeople with Fanconi anemia (show PALB2 ELISA Kits), or healthy people who develop sporadic mutations in FANCD2, may be hypersensitive to the carcinogenic activity of coffee.\nResults indicate the importance of DNA binding and nuclear localization sequences (NLS (show ALDH1A2 ELISA Kits)) residues in Fanconi Anemia Group D2 Protein (FANCD2) to activate an efficient Fanconi anemia (show PALB2 ELISA Kits) (FA) pathway.\nFANCB (show BRCA2 ELISA Kits) dimer coordinates FANCD2:FANCI (show FANCI ELISA Kits) monoubiquitination by two FANCL (show FANCL ELISA Kits) RING-ligases. Deubiquitination of FANCD2:FANCI (show FANCI ELISA Kits) by USP1 (show USP1 ELISA Kits):UAF1 (show WDR48 ELISA Kits) occurs only when DNA is removed.\nThese results reveal a synthetic lethal relationship between FANCD2 and BRCA1/2.\nthese findings provide a previously unrecognized central player FANCD2-V2 and thus novel insights into human tumorigenesis, and indicate that V2/V1 can act as an effective biomarker in assisting the recognition of tumor malignance\nThe data demonstrate that FANCD2 protein is required to ensure efficient chromosome fragile sites (CFS) replication and provide mechanistic insight into how FANCD2 regulates CFS stability.\nA breakdown in a BRCA/FANCD2/BRG1 (show SMARCA4 ELISA Kits)/SNF (show SNRPA ELISA Kits)-DeltaNP63-mediated DNA repair and differentiation maintenance process in mammary epithelial cells may contribute to sporadic breast cancer development.\nFancd2-/- mice exhibit a pervasive developmental HSPC defect that echoes the constitutional defects evident at birth in a subset of FA patients.\nloss of Fancd2 yields significant defects to fetal liver hematopoiesis, particularly the HSC (show FUT1 ELISA Kits) population, which mimics key phenotypes from adult Fancd2 KO bone marrow independently of aging-accrued DNA damage.\nData that suggest Usp1 (ubiquitin specific peptidase 1 (show USP1 ELISA Kits)) down-regulation by autocleavage is critical for Usp1 (show USP1 ELISA Kits) to exert role in DNA interstrand crosslink repair; Usp1 (show USP1 ELISA Kits) role is de-ubiquitination of Fancd2 and Pcna (proliferating cell nuclear antigen (show PCNA ELISA Kits)).\nrecruitment of Fan1 (show FAN1 ELISA Kits) by ubiquitinated-Fancd2 is dispensable for DNA interstrand cross-links repair\nResults show that FANCD2 and ADH5 (show ADH5 ELISA Kits) protect hematopoietic stem cells, hepatocytes, and nephrons from endogenous DNA damage resulting from accumulation of endogenous formaldehyde.\nCombined deficiency of Foxo3a (show FOXO3 ELISA Kits) and Fancc (show FANCC ELISA Kits) or Fancd2 not only impairs the self-renewal capacity but also markedly increases the apoptosis of neural stem and progenitor cells (NSPCs), leading to defective neurogenesis.\nData demonstrated that Fancd2 was required for nuclear retention of CA-FOXO3a (show FOXO3 ELISA Kits) and for maintaining hematopoietic repopulation of the HSCs.\nCD25 (show IL2RA ELISA Kits)(+)Foxp3 (show FOXP3 ELISA Kits)(+) Tregs of Fanca (show FANCA ELISA Kits)(-/-) or Fancd2(-/-) mice were less efficient in suppressing the production of GVHD-associated inflammatory cytokines.\nFancd2-Ub activates the transcription of the tumor suppressor TAp63, thereby promoting cellular senescence and blocking skin tumorigenesis.\nStudies indicate that in Fancd2-Knockout mice, the formation of sex-cords and intraovarian tubules lead to the formation of tumours with multiple phenotypes including luteomas, papillary cysts and malignant carcinomas.\nThe Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity\\; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group D2. This protein is monoubiquinated in response to DNA damage, resulting in its localization to nuclear foci with other proteins (BRCA1 AND BRCA2) involved in homology-directed DNA repair. Alternative splicing results in two transcript variants encoding different isoforms.\nFanconi anemia, complementation group D2\n, Fanconi anemia group D2 protein-like\n, fanconi anemia protein FANCD2\n, Fanconi anemia complementation group D2\n, Fanconi anemia group D2 protein\n, Fanconi anemia group D2 protein homolog\n, Fanconi anemia D2 protein", "domain": "chemistry", "round": 3} +{"url": "https://myfeelstate.com/terpenes-linalool/", "date": "2023-09-23T11:31:33Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233506480.7/warc/CC-MAIN-20230923094750-20230923124750-00365.warc.gz", "language_score": 0.9430471062660217, "token_count": 375, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__37024266", "lang": "en", "text": "Linalool is a common terpene found in cannabis varieties, however it is most abundantly found in lavender. Think of an experience you’ve had with lavender. Maybe you’ve had a massage with lavender oil or have walked through a lavender field. What did you feel?\nIf you’ve interacted with lavender before, you have most likely felt relaxed and calm after your experience. This relaxing and calming energy is a result of linalool. Linalool is the primary constituent found in lavender and it even helps the bees who feed on the flowers of lavender to relax. Here is a snapshot of linalool might affect a cannabis experience:\nAroma. Aroma helps us to identify terpenes when we don’t have lab results. Terpenes are consumed through our olfactory glands before we even inhale or ingest. Therefore, the smell of a variety can affect the experience. It also may contribute to taste.\nEffects on mood: In cannabis, linalool most likely contributes to a sedative, stress relieving experience and may help to elevate mood, alleviate stress and anxiety and calm both the body and mind. Linalool helps those who might have trouble sleeping due to excessive stress and anxiety. It often creates a lovely relaxing energy.\nMost Notable Medicinal Properties: Anti-anxiety, Sedative, Anti-depressant, Immune potentiator, Analgesic, Anti-oxidant\nSynergistic Properties: When combined with THCA and CBD, linalool exhibits anticonvulsant efficacy, making it an essential ingredient for cannabis formulations that help to manage seizure disorders. Linalool has also exhibited impact on liver enzymes, therefore linalool may affect the way in which cannabis is processed via oral ingestion.", "domain": "chemistry", "round": 3} +{"url": "http://inst-biopharmsci.org/%EF%BB%BFdata-availability-statementnot-applicable-2/", "date": "2022-07-02T16:29:00Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-27/segments/1656104189587.61/warc/CC-MAIN-20220702162147-20220702192147-00073.warc.gz", "language_score": 0.9133977890014648, "token_count": 1251, "dump": "CC-MAIN-2022-27", "global_id": "webtext-fineweb__CC-MAIN-2022-27__0__238430470", "lang": "en", "text": "Data Availability StatementNot applicable. current research challenges and identify fresh avenues in translational and preliminary research. A significant feature of the conference was the involvement of youthful researchers and trainees with this particular region, two (A. N and Dekhne. Verweij) of whom had been awarded fellowships to wait this conference as a reputation from the high medical quality of the work. This record offers a synopsis from the highlights presented in the following sessions: Barton Kamen Lecture; Targeting one-carbon metabolism in cytosol and mitochondria; Structure and biology of the one-carbon solute transporters; Physiology and pathophysiology of folate receptors and transporters; Folate receptors for targeting tumors and inflammatory diseases; Conventional and new anti-folate drugs for treating inflammatory diseases and cancer; Imaging; Ongoing clinical trials; and Chimeric Antigen Receptor cell therapies of cancer. in honor of the late Barton Kamen, a pioneering physician-scientist and major contributor to folate receptor (FR) Bakuchiol biology for many decades. Dr. Kamen was a former trainee during his pediatric residency at Yale and a later colleague at the Cancer Institute of New Jersey and the Robert Wood Johnson Medical School, now part of Rutgers University. Dr. Bertino gave an overview of one-carbon (C1) metabolism, its compartmentalization in mitochondria and cytosol, and the promise of therapeutic targeting mitochondrial C1 metabolism in cancer. Mitochondrial C1 metabolism, provides glycine, NAD(P) H, ATP and Bakuchiol C1 units Rabbit Polyclonal to MEKKK 4 for cytosolic biosynthetic reactions . Key enzymes in this pathway include serine hydroxymethyltransferase (SHMT) 2 and NAD-dependent methylene tetrahydrofolate dehydrogenase (MTHFD) 2, both of which are upregulated in Bakuchiol tumor frequently. Dr. Bertino observed that like specific various other C1 enzymes, MTHFD2 continues to be reported within the nucleus where it co-localizes with DNA replication sites . The importance of Bakuchiol the finding is evolving still. Furthermore, adult and embryonic tissue exhibit mitochondrial MTHFD2L, a bifunctional enzyme, homologous to MTHFD2, making use of NAD/NADP as cofactor . In his chat, he observed that MTHFD2 is certainly extremely portrayed in quickly replicating tumor cells however, not in regular adult tissue, providing a strong rationale for targeting this enzyme for selective cancer treatment (see Fig.?1 right side). He noted that MTHFD2 is a bifunctional enzyme with both MTHFD and cyclohydrolase activities that distinguish it from the homologous trifunctional cytoplasmic enzyme MTHFD1 that includes dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase activities. Bertino described approaches for the rational design of MTHFD2 inhibitors, drawing from structural studies of homologous enzymes including the human cytoplasmic MTHFD1 for which the bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase domain has been crystalized with an inhibitor (“type”:”entrez-nucleotide”,”attrs”:”text”:”LY345899″,”term_id”:”1257862889″,”term_text”:”LY345899″LY345899). Although no inhibitor for MTHFD2 has yet emerged, its overexpression in rapidly replicating tumor tissues but not in normal tissues and the finding that knockdown of MTHFD2 effects a strong antiproliferative response in tumor cells provide compelling rationale for targeting MTHFD2 in cancer [5, 6]. Open in a separate windows Fig. 1 Main aspects of folate receptor signaling and C1 metabolism discussed during the meeting. Three types of folate transporters/receptors are known to exist in humans to facilitate the uptake of folate: Folate Receptors (FRs), Reduced Folate Carrier (RFC) and Proton-Coupled Folate Transporter (PCFT) . Left side: Folate binding to FRs can induce STAT3 activation via a GP130 co-receptor mediated JAK-dependent process. Folate can also bind FRs undergoing endocytosis and upon released FRs are set free to act like transcription factors . Right side: Folate, through an interlinked set of mitochondrial and cytosolic reactions, support the C1 metabolism and the main pathway reactions are depicted [1, 6]. THF: tetrahydrofolate; MTHFR, methylenetetrahydrofolate reductase; SHMT1/2, serine hydroxymethyl transferase in cytosol (1) and mitochondrial (2); MTHFD1, methylenetetrahydrofolate dehydrogenase 1; MTHFD2, methylenetetrahydrofolate dehydrogenase 2; 10-f-THF: 10-formyl- tetrahydrofolate; GARFTase: glycinamide ribonucleotide formyltransferase; AICARFTase: 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase Targeting one-carbon metabolism in cytosol and mitochondria Following Bertinos lecture, several speakers further discussed the subject of compartmentalization and targeting C1 metabolism. G. Ducker (University of Utah, USA) gave a presentation entitled in which he described analytical methods for characterizing the sub-cellular compartmentalization of C1 metabolism like the metabolic fluxes. The concentrate was on mass spectrometry-based isotope.\nData Availability StatementNot applicable", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/scavenging-receptor-sr-bi-antibody-ab137829.html", "date": "2020-07-05T22:38:58Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-29/segments/1593655889877.72/warc/CC-MAIN-20200705215728-20200706005728-00439.warc.gz", "language_score": 0.7621979713439941, "token_count": 844, "dump": "CC-MAIN-2020-29", "global_id": "webtext-fineweb__CC-MAIN-2020-29__0__117768864", "lang": "en", "text": "Key features and details\n- Rabbit polyclonal to Scavenging Receptor SR-BI\n- Suitable for: WB, IHC-P\n- Reacts with: Human\n- Isotype: IgG\nProduct nameAnti-Scavenging Receptor SR-BI antibody\nSee all Scavenging Receptor SR-BI primary antibodies\nDescriptionRabbit polyclonal to Scavenging Receptor SR-BI\nTested applicationsSuitable for: WB, IHC-Pmore details\nSpecies reactivityReacts with: Human\nPredicted to work with: Rabbit, Cow, Pig\nRecombinant fragment, corresponding to a region within amino acids 290-492 of Human Scavenging Receptor SR-BI (NP_005496).\n- 293T, A431, H1299, HeLa, HepG2, Molt4 whole cell lysates, DLD-1 xenograft tissue.\nStorage instructionsShipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.\nStorage bufferpH: 7.00\nPreservative: 0.01% Thimerosal (merthiolate)\nConstituents: 1.21% Tris, 0.75% Glycine, 20% Glycerol\nConcentration information loading...\nPurityImmunogen affinity purified\n- Pathways and Processes\n- Metabolic signaling pathways\n- Lipid and lipoprotein metabolism\n- Lipid metabolism\nOur Abpromise guarantee covers the use of ab137829 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\n|WB||1/500 - 1/3000. Predicted molecular weight: 60 kDa.|\n|IHC-P||1/100 - 1/1000. Perform heat mediated antigen retrieval before commencing with IHC staining protocol using 10mM Citrate buffer (pH6.0) or Tris-EDTA buffer (pH8.0)|\nFunctionReceptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Probable receptor for HDL, located in particular region of the plasma membrane, called caveolae. Facilitates the flux of free and esterified cholesterol between the cell surface and extracellular donors and acceptors, such as HDL and to a lesser extent, apoB-containing lipoproteins and modified lipoproteins. Probably involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity. Receptor for hepatitis C virus glycoprotein E2. Binding between SCARB1 and E2 was found to be independent of the genotype of the viral isolate. Plays an important role in the uptake of HDL cholesteryl ester.\nTissue specificityWidely expressed.\nSequence similaritiesBelongs to the CD36 family.\nCellular localizationCell membrane. Membrane > caveola. Predominantly localized to cholesterol and sphingomyelin-enriched domains within the plasma membrane, called caveolae.\n- Information by UniProt\n- CD36 and LIMPII analogous 1 antibody\n- CD36 antibody\n- CD36 Antigen like 1 antibody\nab137829 has been referenced in 2 publications.\n- Cai D et al. Maternal Betaine Supplementation throughout Gestation and Lactation Modifies Hepatic Cholesterol Metabolic Genes in Weaning Piglets via AMPK/LXR-Mediated Pathway and Histone Modification. Nutrients 8: (2016). PubMed: 27763549\n- Yang D et al. Complete replication of hepatitis B virus and hepatitis C virus in a newly developed hepatoma cell line. Proc Natl Acad Sci U S A 111:E1264-73 (2014). PubMed: 24616513", "domain": "chemistry", "round": 3} +{"url": "https://www.istc.int/en/projects?status=3&by=location&s_loc=Moscow&page=51", "date": "2021-08-01T11:50:11Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-31/segments/1627046154175.76/warc/CC-MAIN-20210801092716-20210801122716-00019.warc.gz", "language_score": 0.8141664862632751, "token_count": 678, "dump": "CC-MAIN-2021-31", "global_id": "webtext-fineweb__CC-MAIN-2021-31__0__174424834", "lang": "en", "text": "Notice: Undefined index: s_inst in /var/www/vhosts/borovoekurort.kz/httpdocs/pages/projects.php on line 340\nInvestigation of Fission Products Release from Uranium Dioxide at Heat up Under Oxidizing and Reducing Media. VERONIKA Project.\nMolecular-Genetic Analysis of Blood Cells from Persons Exposed to Radiation in their Professional Activity\nDevelopment, Fabrication and Laboratory Testing of New Resonance Mechanical Traps for Protection of Buildings and Engineering Structures against Explosions, Earthquakes\nPower Plant Nozzle Cluster with Altitude Compensation\nDevelopment of Techniques of Nondestructive Assay of Fissile Materials by Neutron and Gamma Radiations in Gas Cleaning Systems and Gas Pipelines\nHard Nano-Strutural Coatings Resistant to the Extreme Conditions of Chemical, Abrasive and High Energy Media for Thermonuclear Power, Oil and Gas and Chemical Industries\nMicro- and Nanoactuators on the Basis of Quasi One-Dimensional Conductors\nCyclophilin A: a Novel Granulocute-Stimulating Factor and a Radioprotector\nStudy of Fuel Assemblies with Boron Carbide Absorber Rods under Severe Accident Conditions in the PARAMETER-SF Tests Series\nExamination of the ETDR Engineering Decisions, Development of Proposals for their Improvement, Analytical and Experimental Studies of Properties of Advanced Fuel and Materials of GCFR Fuel Assembly in the BOR-60\nExperimental Research of Magnetic Energy Transformations in Tridimensional Current Sheets\nCross-Verification and Analysis of Accuracy of Neutron-Physical Codes for Nuclear Reactors RBMK and CANDU\nMeeting Energy Needs in Selected European Countries Faced with a Shortage of Raw Material Resources\nInvestigation and Development of the Method of Electro-Friction Plating of Machine-Parts’, Tool’s and Other Items’ Surface with the Purpose of Improvement of their Working Capacity\nDevelopment of the Novel Technological Scheme of Manufacturing Super-Light Steel High-Pressure Vessels\nInvestigation of the Structural Characteristics of Transformation of Nanodiamonds into Onion-Like Carbon Nanoparticles and Development of the Principles of Designing Composite Materials on their Basis\nDevelopment and Production of Multichannel Measuring System with CVD-Films for Clinical Dosimetry\nDevelopment of Novel Metal-Containing Nanocomposites with Dielectric and Magnetic Properties: Sensor and Spintronic Applications\nDevelopment of the Advanced Systems of Concentration of Radiation of Hard X-Ray Range for Astrophysical Studies\nPhotoelectrical and Optical Properties of Composites Based on Nanostructured Metals in a Matrix of Oxy Compounds in the Infrared Spectral Region\nThe International Science and Technology Center (ISTC) is an intergovernmental organization connecting scientists from Kazakhstan, Armenia, Tajikistan, Kyrgyzstan, and Georgia with their peers and research organizations in the EU, Japan, Republic of Korea, Norway and the United States.\nISTC facilitates international science projects and assists the global scientific and business community to source and engage with CIS and Georgian institutes that develop or possess an excellence of scientific know-how.", "domain": "chemistry", "round": 3} +{"url": "https://www.spaceflightpower.com/electric-forklifts/", "date": "2024-02-27T03:49:33Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707947474670.19/warc/CC-MAIN-20240227021813-20240227051813-00595.warc.gz", "language_score": 0.8475682139396667, "token_count": 1144, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__43553568", "lang": "en", "text": "Analyzing the Market Trends: Lead-Acid Batteries in a Dynamic LandscapeFEB.23,2024\nResilience in Harsh Environments: Lead-Acid Batteries in Military ApplicationsFEB.22,2024\nThe Chemistry of Lead-Acid Battery Electrodes: Unraveling the ComplexityFEB.20,2024\nLead-Acid Batteries and Electric Forklifts: Powering Material HandlingJAN.24,2024\nExploring the Role of Lead-Acid Batteries in Hybrid Power SystemsJAN.23,2024\nWill Your AGM Car Battery Freeze This Winter? How to Keep it RunningJAN.22,2024\nLead-Acid Batteries and Renewable Integration: Storing Green EnergyJAN.19,2024\nThe Impact of Cycling on Lead-Acid Battery PerformanceJAN.17,2024\nHow to Charge Your AGM Battery?JAN.15,2024\nRetrofitting for Efficiency: Upgrading Systems with Lead-Acid BatteriesJAN.12,2024\nSpaceflight Power Supply Co., Ltd.\nAdd: Weimin High-Tech Development Area, Fusha, Zhongshan, Guangdong Province, China\nMaterial handling in warehouses, distribution centers, and manufacturing facilities demands efficient, reliable, and environmentally conscious solutions. In this context, the pairing of lead-acid batteries with electric forklifts has emerged as a powerful combination, offering a myriad of advantages for businesses engaged in material handling operations. Let’s delve into the role of lead-acid batteries in powering electric forklifts and the impact this combination has on the material handling landscape.\nExtended Operational Hours: Lead-acid batteries provide consistent and reliable power, allowing electric forklifts to operate for extended periods.\nMinimal Downtime: The longevity of lead-acid batteries contributes to reduced downtime, optimizing material handling workflows.\nConstant Power Supply: Lead-acid batteries deliver a stable voltage output, ensuring continuous and efficient operation of electric forklifts.\nConsistent Performance: The stable power supply is crucial for maintaining consistent performance in the dynamic environment of material handling.\nHeavy-Duty Design: Lead-acid batteries are engineered with a robust construction, capable of withstanding the demanding conditions of material handling applications.\nVibration Resistance: The design minimizes the impact of vibrations, ensuring longevity in heavy-duty, high-mobility environments.\nVersatility in Forklift Types: Lead-acid batteries support a wide range of electric forklifts, from smaller, nimble models to larger ones with higher lift capacities.\nConsistent Power Output: Regardless of forklift size, lead-acid batteries provide the necessary power for lifting and transporting heavy loads.\nEconomical Investment: Lead-acid batteries are often more affordable upfront compared to some alternative technologies, making them a cost-effective choice.\nIdeal for Fleet Deployments: In scenarios where multiple forklifts are part of a fleet, the economical nature of lead-acid batteries contributes to overall cost efficiency.\nEase of Maintenance: Lead-acid batteries have relatively simple maintenance requirements, reducing the need for specialized personnel or complex maintenance procedures.\nMinimal Service Disruption: Forklifts can quickly return to operations after routine maintenance, minimizing disruptions in material handling activities.\nCompatibility with Standard Chargers: Lead-acid batteries can be charged using standard charging infrastructure, offering flexibility in deployment.\nOpportunity Charging: The adaptability of lead-acid batteries allows for convenient opportunity charging during breaks, ensuring continuous availability.\nAdvancements in Charging Technology: Ongoing innovations focus on enhancing the efficiency of lead-acid battery charging processes.\nReduced Charging Times: Faster charging times contribute to increased forklift availability during peak operational hours.\nHigh Recyclability: Lead-acid batteries are highly recyclable, aligning with sustainability goals in material handling operations.\nReduced Environmental Impact: Proper recycling practices minimize the environmental impact, making lead-acid batteries a responsible choice.\nZero Emissions: Electric forklifts powered by lead-acid batteries offer a clean and emission-free alternative to internal combustion counterparts.\nIndoor Operation Suitability: The absence of emissions makes them suitable for indoor material handling, contributing to a healthier work environment.\nAdaptability to Temperature Extremes: Lead-acid batteries can operate efficiently in a range of temperatures, making them suitable for diverse material handling environments.\nCold Storage Applications: Forklifts equipped with lead-acid batteries can navigate cold storage facilities without compromising performance.\nCompatibility with Automated Systems: Lead-acid batteries seamlessly integrate with automated material handling systems.\nSupport for Technological Advancements: As warehouses embrace automation, lead-acid batteries continue to be a reliable power source for automated forklifts and conveyance systems.\nImproving Energy Density: Ongoing research explores advanced materials to enhance the energy density of lead-acid batteries.\nMeeting Evolving Needs: Innovations aim to address the evolving requirements of material handling operations, such as increased energy demands.\nIn conclusion, the synergy between lead-acid batteries and electric forklifts is pivotal in empowering material handling operations for the future. The combination offers a balance of efficiency, reliability, and environmental responsibility, making it an enduring choice for businesses seeking optimized solutions for their material handling needs. As technological advancements continue and sustainability becomes an even greater priority, lead-acid batteries are poised to play a crucial role in the evolution of material handling practices worldwide.", "domain": "chemistry", "round": 3} +{"url": "https://mrsspring2018.zerista.com/event/member/467652?embedded=1", "date": "2020-10-30T02:00:14Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-45/segments/1603107906872.85/warc/CC-MAIN-20201030003928-20201030033928-00187.warc.gz", "language_score": 0.9081369042396545, "token_count": 382, "dump": "CC-MAIN-2020-45", "global_id": "webtext-fineweb__CC-MAIN-2020-45__0__21712458", "lang": "en", "text": "2, University of Delaware, Newark, Delaware, United States\n3, University of Florida, Gainsville, Florida, United States\nGiven that organ function is regulated by neurological signals, various diseases can potentially be treated via bioelectronic devices that modulate these signals. However, state-of-the-art micro-cuffs based on rigid pad, wire, and pin electrodes do not yet provide fiber type selectivity or precision below the length scale of the electrode, which is a major limitation for achieving targeted stimulation of peripheral nerves that innervate critical organs. Thus, a technique for intrafascicular, molecular-guided formation of fiber type-selective polymer electrodes could potentially enable novel bioelectronic therapies for organ health. Here, we describe the in situ deposition of conjugated polymers for direct, local interfacing with peripheral nerves from custom designed electrodes created by 3D printing. In vitro experiments using hydrogel nerve mimics and explanted peripheral nerve tissue showed that polythiophene-based polymer electrodes could be polymerized in situ by application of cuff voltages above the polymerization threshold of the monomer species. In vivo studies showed precise control of the deposition by changing the size, shape, and location of the working and counter electrodes. 3D printing was leveraged to create micro-cuffs with programmable symmetric and asymmetric pad and wire electrode configurations to explore the potential for omni-directional guidance of the in situ deposited polymer, as well as to customize the mechanical and anatomical matching of printed cuffs and small diameter nerves. The experimentally observed conjugated polymer electrode polymerization trajectories showed agreement with finite element simulations of electric field and current density distributions in the 3D printed micro-cuffs. This work shows the potential to achieve fiber type-selective electrodes for peripheral nerve stimulation via directed in situ polymerization of conducting polymers.", "domain": "chemistry", "round": 3} +{"url": "https://www.joasdjournal.com/paper042020", "date": "2023-09-22T22:37:47Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233506423.70/warc/CC-MAIN-20230922202444-20230922232444-00429.warc.gz", "language_score": 0.9031211137771606, "token_count": 304, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__213649604", "lang": "en", "text": "top of page\nJOURNAL OF OASIS AGRICULTURE AND SUSTAINABLE DEVELOPMENT\np-ISSN (Print Version): 2724 - 699X\ne-ISSN (Electronic Version): 2724-7007\nComparison of the effectiveness of the most used chemicals against Tuta absoluta in Tunisia\nEttaib Refki, Aoun Faouzi, Assadi Besma, Ben Belgacem Ali , Chouikhi Sabrine, Bazmi Ali and BelKadhi Mohamed Sadok\nControl failures with several chemicals have prompted research into the resistance status of Tuta absoluta and the effectiveness of certain active ingredients against this pest. In this context, a comparison was made of the effectiveness of the most widely used chemicals against T. absoluta in Tunisia. The results show that the L1 larval stage of Tuta absoluta is very sensitive to all of the chemicals tested. Stage L2 is sensitive to Spinosad, indoxacarb and emactin, while Bacillus thuringiensis, martine do not cause 50% mortality. L3 stage mortality fluctuates between 20% and 80% mortality. The L4 stage is more affected by the treatment with Bacillus thuringiensis which can go to 100%. Based on these results, chemical treatments should be directed according to the dominant larval stage in the plants.\nbottom of page", "domain": "chemistry", "round": 3} +{"url": "http://www.researchgate.net/publication/221865858_Ethyl_pyruvate_induces_heme_oxygenase-1_through_p38_mitogen-activated_protein_kinase_activation_by_depletion_of_glutathione_in_RAW_264.7_cells_and_improves_survival_in_septic_animals", "date": "2015-04-27T00:21:46Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2015-18/segments/1429246656887.93/warc/CC-MAIN-20150417045736-00111-ip-10-235-10-82.ec2.internal.warc.gz", "language_score": 0.8987271189689636, "token_count": 1706, "dump": "CC-MAIN-2015-18", "global_id": "webtext-fineweb__CC-MAIN-2015-18__0__185906610", "lang": "en", "text": "Ethyl pyruvate induces heme oxygenase-1 through p38 mitogen-activated protein kinase activation by depletion of glutathione in RAW 264.7 cells and improves survival in septic animals.\nABSTRACT We investigated the molecular mechanism by which ethyl pyruvate (EP) induces heme oxygenase-1 (HO-1) in RAW 264.7 cells and its effect on survival rate in cecal ligation and puncture (CLP)-induced wild-type (WT) and HO-1 knockout (HO-1(-/-)) septic mice.\nEP induced HO-1 in a dose- and time-dependent manner, which was mediated through p38 mitogen-activated protein kinase (MAPK) and NF-E2-related factor 2 (Nrf2) signaling cascade in RAW 264.7 cells. EP significantly inhibited the lipopolysaccharide (LPS)-stimulated inducible nitric oxide synthase (iNOS) expression and high-mobility group box 1 (HMGB1) release in RAW 264.7 cells. The inhibitory effect of EP on LPS-stimulated iNOS expression and HMGB1 release was reversed by transfection with siHO-1RNA in RAW 264.7 cells, but EP failed to reduce them in HO-1(-/-) peritoneal macrophages treated with LPS. Moreover, treatment of cells with glutathione ethyl ester (GSH-Et), SB203580 (p38 MAPK inhibitor), siHO-1, or p38-siRNA transfection inhibited anti-inflammatory effect of EP. Interestingly, both HO-1 induction and phosphorylation of p38 by EP were reversed by GSH-Et, and antioxidant redox element-luciferase activity by EP was reversed by SB203580 in LPS-activated cells. EP increased survival and decreased serum HMGB1 in CLP-WT mice, whereas it did not increase survival or decrease circulating HMGB1 in HO-1(-/-) CLP-mice. Innovation and\nOur work provides new insights into the understanding the molecular mechanism by showing that EP induces HO-1 through a p38 MAPK- and NRF2-dependent pathway by decreasing GSH cellular levels. We conclude that EP inhibits proinflammatory response to LPS in macrophages and increases survival in CLP-induced septic mice by upregulation of HO-1 level, in which p38 MAPK and Nrf2 play an important role.\nSourceAvailable from: PubMed Central[Show abstract] [Hide abstract]\nABSTRACT: Glutamine has a positive effect on ameliorating reproductive failure caused by porcine circovirus type 2 (PCV2). However, the mechanism by which glutamine affects PCV2 replication remains unclear. This study was conducted to investigate the effects of glutamine on PCV2 replication and its underlying mechanisms in vitro. The results show that glutamine promoted PK-15 cell viability. Surprisingly, glutamine starvation significantly increased PCV2 replication. The promotion of PCV2 replication by glutamine starvation disappeared after fresh media with 4 mM glutamine was added. Likewise, promotion of PCV2 was observed after adding buthionine sulfoximine (BSO). Glutamine starvation or BSO treatment increased the level of p38 MAPK phosphorylation and PCV2 replication in PK-15 cells. Meanwhile, p38 MAPK phosphorylation and PCV2 replication significantly decreased in p38-knockdown PK-15 cells. Promotion of PCV2 replication caused by glutamine starvation could be blocked in p38-knockdown PK-15 cells. Therefore, glutamine starvation increased PCV2 replication by promoting p38 MAPK activation, which was associated with the down regulation of intracellular glutathione levels. Our findings may contribute toward interpreting the possible pathogenic mechanism of PCV2 and provide a theoretical reference for application of glutamine in controlling porcine circovirus-associated diseases.Veterinary Research 01/2015; 46(1):32. DOI:10.1186/s13567-015-0168-1 · 3.38 Impact Factor\n[Show abstract] [Hide abstract]\nABSTRACT: To study the anti-neuroinflammatory mechanisms of polygalasaponin F (PS-F), ELISA method was used to detect the secretion of inflammatory cytokines. Western blot was used to detect the protein expression and phosphorylation levels. Immunofluorescence assay was used to observe the NF-κB nuclear translocation. PS-F could inhibit the release of inflammatory cytokines TNF-α and NO induced by lipopolysaccharides (LPS) and reduce the expression of inducible nitric oxide synthases (iNOS). As for MAPK-signaling pathway, PS-F could only inhibit the phosphorylation levels of p38 MAPK, but did not significantly affect the phosphorylation levels of JNK and ERK1/2 protein kinases. PS-F could inhibit NF-κB nuclear translocation in a dose-dependent manner. The results of Western blot assay were consistent with immunofluorescence assays. Meanwhile, p38-specific inhibitor SB203580 (20 μM) and p65-specific inhibitor PDTC (100 μM) were, respectively, administered as a positive control. In addition, PS-F could significantly inhibit the cytotoxicity of conditioned medium prepared by LPS-stimulated BV-2 microglia (LPS conditioned media) to neuronal PC12 cells and improve cell viability. PS-F inhibits the secretions of neuroinflammatory cytokines by the regulation of NF-κB-signaling pathway.Journal of Asian Natural Products Research 08/2014; 16(8):1-11. DOI:10.1080/10286020.2014.918962 · 0.97 Impact Factor\n[Show abstract] [Hide abstract]\nABSTRACT: Ethyl pyruvate (EP) is a simple aliphatic ester of the metabolic intermediate pyruvate that has been demonstrated to be a potent anti-inflammatory agent in a variety of in vivo and in vitro model systems. However, the protective effects and mechanisms underlying the actions of EP against endothelial cell (EC) inflammatory injury are not fully understood. Previous studies have confirmed that endoplasmic reticulum stress (ERS) plays an important role in regulating the pathological process of EC inflammation. In this study, our aim was to explore the effects of EP on tumor necrosis factor-α (TNF-α)-induced inflammatory injury in human umbilical vein endothelial cells (HUVECs) and to explore the role of ERS in this process. TNF-α treatment not only significantly increased the adhesion of monocytes to HUVECs and inflammatory cytokine (sICAM1, sE-selectin, MCP-1 and IL-8) production in cell culture supernatants but it also increased ICAM and MMP9 protein expression in HUVECs. TNF-α also effectively increased the ERS-related molecules in HUVECs (GRP78, ATF4, caspase12 and p-PERK). EP treatment effectively reversed the effects of the TNF-α-induced adhesion of monocytes on HUVECs, inflammatory cytokines and ERS-related molecules. Furthermore, thapsigargin (THA, an ERS inducer) attenuated the protective effects of EP against TNF-α-induced inflammatory injury and ERS. The PERK siRNA treatment not only inhibited ERS-related molecules but also mimicked the protective effects of EP to decrease TNF-α-induced inflammatory injury. In summary, we have demonstrated for the first time that EP can effectively reduce vascular endothelial inflammation and that this effect at least in part depends on the attenuation of ERS.PLoS ONE 12/2014; 9(12):e113983. DOI:10.1371/journal.pone.0113983 · 3.53 Impact Factor", "domain": "chemistry", "round": 3} +{"url": "https://www.omicsonline.org/references/increased-level-of-extracellular-atp-at-tumor-sites-in-vivo-imaging-with-plasma-membrane-luciferase-256564.html", "date": "2017-11-21T20:12:03Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-47/segments/1510934806422.29/warc/CC-MAIN-20171121185236-20171121205236-00538.warc.gz", "language_score": 0.9089342355728149, "token_count": 488, "dump": "CC-MAIN-2017-47", "global_id": "webtext-fineweb__CC-MAIN-2017-47__0__18191463", "lang": "en", "text": "Author(s): Pellegatti P, Raffaghello L, Bianchi G, Piccardi F, Pistoia V,\nAbstract Share this page\nAbstract BACKGROUND: There is growing awareness that tumour cells build up a \"self-advantageous\" microenvironment that reduces effectiveness of anti-tumour immune response. While many different immunosuppressive mechanisms are likely to come into play, recent evidence suggests that extracellular adenosine acting at A2A receptors may have a major role in down-modulating the immune response as cancerous tissues contain elevated levels of adenosine and adenosine break-down products. While there is no doubt that all cells possess plasma membrane adenosine transporters that mediate adenosine uptake and may also allow its release, it is now clear that most of extracellularly-generated adenosine originates from the catabolism of extracellular ATP. METHODOLOGY/PRINCIPAL FINDINGS: Measurement of extracellular ATP is generally performed in cell supernatants by HPLC or soluble luciferin-luciferase assay, thus it generally turns out to be laborious and inaccurate. We have engineered a chimeric plasma membrane-targeted luciferase that allows in vivo real-time imaging of extracellular ATP. With this novel probe we have measured the ATP concentration within the tumour microenvironment of several experimentally-induced tumours. CONCLUSIONS/SIGNIFICANCE: Our results show that ATP in the tumour interstitium is in the hundreds micromolar range, while it is basically undetectable in healthy tissues. Here we show that a chimeric plasma membrane-targeted luciferase allows in vivo detection of high extracellular ATP concentration at tumour sites. On the contrary, tumour-free tissues show undetectable extracellular ATP levels. Extracellular ATP may be crucial for the tumour not only as a stimulus for growth but also as a source of an immunosuppressive agent such as adenosine. Our approach offers a new tool for the investigation of the biochemical composition of tumour milieu and for development of novel therapies based on the modulation of extracellular purine-based signalling.\nThis article was published in PLoS One\nand referenced in Pharmaceutica Analytica Acta", "domain": "chemistry", "round": 3} +{"url": "http://www.sciencepublishinggroup.com/journal/paperinfo?journalid=121&doi=10.11648/j.mc.20190703.14", "date": "2020-10-23T02:32:49Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-45/segments/1603107880519.12/warc/CC-MAIN-20201023014545-20201023044545-00104.warc.gz", "language_score": 0.6734226942062378, "token_count": 4870, "dump": "CC-MAIN-2020-45", "global_id": "webtext-fineweb__CC-MAIN-2020-45__0__105242043", "lang": "en", "text": "A Theoretical Study on the Stability, Reactivity and Protonic Affinity of 2-Phenylbenzothiazole Derivatives\nThe 2-phenylbenzothiazole derivatives have antitumor activities. Work has shown that these derivatives have mesomeric forms. The electrophilic centers of these mesomers form adducts with the nucleophilic centers of deoxyribonucleic acid (DNA). These adducts destroy the tumor cells and prevent the proliferation of these. In this sense, the knowledge of electrophilic sites, nucleophiles and the capacity to protonate these derivatives is therefore useful if we want to know their future in the biological environment. Using DFT/B3LYP method associated with the bases 6-31G (d, p) and 6-31+G (d, p), this work aims at determining the preferential protonation site, the electrophilic and nucleophilic centers of six 2-phenylbenzothiazole. This study also analyzes the stability of these derivatives. Calculations are carried out in gas and aqueous phases. Results show that fluorinated derivatives are the most stable. 2-(4-aminophenyl) benzothiazoles are the most reactive. The atoms carbon C4, C5 and C6 of benzothiazole ring are the most electrophilic. Interactions of these derivatives with nucleophilic centers of deoxyribonucleic acid (DNA) will probably be at these atoms. Nitrogen sp2 (N1) of benzothiazole ring remains the most nucleophilic center and the preferential site of protonation in all the molecules studied. These results highlight the influence of the substituents on the basicity of the nitrogen sp2 (N1) and reactivity of the 2-phenylbenzothiazole derivatives studied.\nBede Affoue Lucie,\nN’Guessan Boka Robert,\nYapo Kicho Denis,\nA Theoretical Study on the Stability, Reactivity and Protonic Affinity of 2-Phenylbenzothiazole Derivatives, Modern Chemistry. Special Issue: Advanced Journal of Chemistry.\nVol. 7, No. 3,\n2019, pp. 65-72.\nA. Ly, Current issues and future prospects in cancer prevention in developing countries, African Journal of Cancer, 2011, 3, 4, 268‑272.\nJ. M. Dangou, B.-H. Sambo, M. Moeti and A.-J. Diarra-Nama, Prévention et lutte contre le cancer dans la région africaine de l’OMS: un appel à l’action, African Journal of Cancer, 2009, 1, 1, 56‑60.\nD. Moukassa, A. M. Boumba, C. F. Ngatali, A. Ebatetou, J. B. N. Mbon and J.-R. Ibara, Virus-Induced Cancers in Africa: Epidemiology and Carcinogenesis Mechanisms, Open Journal of Pathology, 2018, 8, 1-14.\nM. Ly, A. Ly, M. Rodrigues, Y. Loriot, M. Deberne, PP. Boudou-Rouquette, T. Bathily and D. Diallo, Cancer in Africa, a new health challenge. Examples of Mali and OncoMali, Bulletin du Cancer, 2010, 97, 8, 965‑968.\nH. B. El–Serag, and K. L. Rudolph, Hepatocellular Carcinoma: Epidemiology and Molecular Carcinogenesis, Gastroenterology, 2007, 132, 7, 2557–2576.\nX. Peng, G. Xie, Z. Wang, H. Lin, T. Zhou, P. Xiang and Y. Zhao, SKLB-163, a new benzothiazole-2-thiol derivative, exhibits potent anticancer activity by affecting RhoGDI/JNK-1 signaling pathway, Cell Death & Disease, 2014, 5, 3, e1143.\nS. Ke, Y. Wei, Z. Yang, K. Wang, Y. Liang and L. Shi, Novel cycloalkylthiophene–imine derivatives bearing benzothiazole scaffold: Synthesis, characterization and antiviral activity evaluation, Bioorganic & Medicinal Chemistry Letters, 2013, 23, 18, 5131‑5134.\nJ. Zhang, Z. Q. Cheng, J. L. Song, H. R. Tao, K. Zhu, L. A. Muehlmann, C. S. Jiang and H. Zhang, Synthesis and biological evaluation of 2-(3-aminophenyl)-benzothiazoles as antiproliferative and apoptosis-inducing agents, Monatshefte Für Chemie-Chemical Monthly, 2018, 149, 11, 2093‑2102.\nP. Linciano, C. Pozzi, L. D. Iacono, F. di PIsa, G. Landi, A. Bonucci, S. Gul, M. Kuzikov, B. Ellinger, G. Witt, N. Santarem, C. Baptista, C. Franco, C. B. Moraes, W. Müller, U. Wittig, R. Luciani, A. Sesenna, A. Quotadamo, S. Ferrari, I. Pöhner, A. C. Da-Silva, S. Mangani, L. Costantino, and M. P. Costi, Enhancement of Benzothiazoles as Pteridine Reductase-1 Inhibitors for the Treatment of Trypanosomatidic Infections, Journal of Medicinal Chemistry, 2019, 62, 8, 3989‑4012.\nA. Trapania, A. Catalanoa, A. Caroccia, A. Carrieria, A. Mercurioa, A. Rosatoa, D. Mandracchiaa, G. Tripodob, B. I. P. Schiavonea, C. Franchinia, E. Mestoc, E. Schingaroc and F. Corboa, Effect of Methyl-β-Cyclodextrin on the antimicrobial activity of a new series of poorly water-soluble benzothiazoles, Carbohydrate Polymers, 2019, 207, 720‑728.\nJ. A. Johnson, G. Tora, Z. Pi, M. Phillips, X. Yin, R. Yang, L. Zhao, A. Y. Chen, D. S. Taylor, M. Basso, A. Rose, K. Behnia, J. Onorato, X. Q. Chen, L. M. Abell, H. Lu, G. Locke, C. Caporuscio, M. Galella, L. P. Adam, D. Gordon, R. R. Wexler and H. J. Finlay, Sulfonylated Benzothiazoles as Inhibitors of Endothelial Lipase, ACS Medicinal Chemistry Letters, 2018, 9, 12, 1263‑1268.\nM. N. Noolvi, H. M. Patel, and M. Kaur, Benzothiazoles: search for anticancer agents, European journal of medicinal chemistry, 2012, 54, 447‑462.\nC. G. Mortimer, G. Wells, J. P. Crochard, E. L. Stone, T. D. Bradshaw, M. F. G. Stevens and A. D. Westwell, Antitumor Benzothiazoles. 26. 2-(3, 4-Dimethoxyphenyl) -5-fluorobenzothiazole (GW 610, NSC 721648), a Simple Fluorinated 2-Arylbenzothiazole, Shows Potent and Selective Inhibitory Activity against Lung, Colon, and Breast Cancer Cell Lines, Journal of Medicinal Chemistry, 2006, 49, 1, 179‑185.\nT. D. Bradshaw and A. D. Westwell, The development of the antitumour benzothiazole prodrug, Phortress, as a clinical candidate, Current medicinal chemistry, 2004, 11, 8, 1009-1021.\nI. Hutchinson, M. S. Chua, H. L. Browne, V. Trapani, T. D. Bradshaw, A. D. Westwell and M. F. G. Stevens, Antitumor Benzothiazoles. 14.1 Synthesis and in Vitro Biological Properties of Fluorinated 2- (4-Aminophenyl) benzothiazoles, Journal of Medicinal Chemistry, 2001, 44, 9, 1446‑1455.\nE. Brantley, V. Patel, S. F. Stinson, V. Trapani, C. D. Hose, H. P. Ciolino, G. C. Yeh, J. S. Gutkind, E. A. Sausville and A. I. Loaiza-Pérez, The antitumor drug candidate 2-(4-amino-3-methylphenyl) -5-fluorobenzothiazole induces NF-κB activity in drug-sensitive MCF-7 cells, AntiCancer Drugs, 2005, 16, 2, 137-142.\nS. H. Kok, R. Gambari, C. H. Chui, M. C. Yuen, E. Lin, R. S. Wong, F. Y. Lau, G. Y. Cheng, W. S. Lam, S. H. Chan, K. H. Lam, C. H. Cheng, P. B. Lai, M. W. Yu, F. Cheung, J. C. Tang and A. S. C. Chan, Synthesis and anticancer activity of benzothiazole containing phthalimide on human carcinoma cell lines, Bioorganic & Medicinal Chemistry, 2008, 16, 7, 3626‑3631.\nY. Zhang, M. Chakraborty, C. G. Cerda-Smith, R. N. Bratton, N. E. Maurer, E. M. Senser, and M. Novak., Chemistry of Ring-Substituted 4- (Benzothiazol-2-yl) phenylnitrenium Ions from Antitumor 2- (4-Aminophenyl) benzothiazoles. Journal of Organic Chemistry, 2013, 78, 14, 6992‑7000.\nT. D. Bradshaw, D. F. Shi, R. J. Schultz, K. D. Paull, L. Kelland, A. Wilson, C. Garner, H. H. Fiebig, S. Wrigley and M. F. G. Stevens, Influence of 2-(4-aminophenyl) benzothiazoles on growth of human ovarian carcinoma cells in vitro and in vivo, British Journal of Cancer, 1998, 78, 4, 421-429.\nA. Wallqvist, J. Connelly, E. A. Sausville, D. G. Covell, and A. Monks, Differential Gene Expression as a potential classifier of 5F-203 Sensitive and Insensitive Cell Lines, Molecular Pharmacology, 2006, 69, 3, 737‑748.\nS. Aiello, G. Wells, E. L. Stone, H. Kadri, R. Bazzi, D. R. Bell, M. F. G. Stevens, C. S. Matthews, T. D. Bradshaw and A. D. Westwell, Synthesis and Biological Properties of Benzothiazole, Benzoxazole, and Chromen-4-one Analogues of the Potent Antitumor Agent 2-(3, 4-Dimethoxyphenyl) -5-fluorobenzothiazole (PMX 610, NSC 721648) (1). Journal of Medicinal Chemistry, 2008, 51, 16, 5135‑5139.\nC. O. Leong, M. Suggitt, D. J. Swaine, M. C. Bibby, M. F. G. Stevens, and T. D. Bradshaw, In vitro, in vivo, and in silico analyses of the antitumor activity of 2-(4-amino-3-methylphenyl) -5-fluorobenzothiazoles, Molecular Cancer Therapeutics, 2004, 3, 12, 1565‑1575.\nT. D. Bradshaw, E. L. Stone, V. Trapani, C. O. Leong, C. S. Matthews, R. Poele, M. F. G. Stevens, Mechanisms of acquired resistance to 2-(4-Amino-3-methylphenyl) benzothiazole in breast cancer cell lines, Breast Cancer Research and Treatment, 2008, 110, 1, 57‑68.\nM. S. Chua, E. Kashiyama, T. D. Bradshaw, S. F. Stinson, E. Brantley, E. A. Sausville, and M. F. Stevens, Role of CYP1A1 in Modulation of Antitumor Properties of the Novel Agent 2- (4-Amino-3-methylphenyl) benzothiazole (DF 203, NSC 674495) in Human Breast Cancer Cells, Cancer Research, 2000, 60, 5196-5203.\nB. S. Tan, K. H. Tiong, A. Muruhadas, N. Randhawa, H. L. Choo, T. D. Bradshaw, M. F. G. Stevens and C. O. 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Shields, Absolute pKa Determinations for Substituted Phenols, Journal of the American Chemical Society, 2002, 124, 22, 6421‑6427.\nB. R. Scott, G. L. Dorn, E. Käfer, and R. Stafford, Aspergillus nidulans: systems and results of tests for induction of mitotic segregation and mutation. II. Haploid assay systems and overall response of all systems. A report of the U.S. EPA Gene-Tox Program, Mutation Research, 1982, 98, 1, 49‑94.\nM. Belletête, J.-F. Morin, M. Leclerc, and G. Durocher, A Theoretical, Spectroscopic, and Photophysical Study of 2, 7-Carbazolenevinylene-Based Conjugated Derivatives, Journal of Physical Chemistry A, 2005, 109, 31, 6953‑6959.\nJ. Aihara, Reduced HOMO−LUMO gap as an index of kinetic stability for polycyclic aromatic hydrocarbons, Journal of Physical Chemistry A, 1999, 103, 37, 7487‑7495.\nA. A. Shabana, I. S. Butler, D. F. R. Gilson, B. J. Jean-Claude, Z. S. Mouhri, M. M. Mostafa, and S. I. Mostafa, Synthesis, characterization, anticancer activity and DNA interaction studies of new 2-aminobenzothiazole complexes; crystal structure and DFT calculations of [Ag(Habt)2] ClO4, Inorganica Chimica Acta, 2014, 423, 242‑255.\nC. O. Leong, M. Gaskell, E. A. Martin, R. T. Heydon, P. B. Farmer, M. C. Bibby, P. A. Cooper, J. A. Double, T. D. Bradshaw and M. F. G. Stevens, Antitumour 2-(4aminophenyl) benzothiazoles generate DNA adducts in sensitive tumour cells in vitro and in vivo, British Journal of Cancer, 2003, 88, 3, 470-477.\nR. K. Roy, S. Pal, and K. Hirao, On non-negativity of Fukui function indices, Journal of chemical physics, 1999, 110, 17, 8236‑8245.", "domain": "chemistry", "round": 3} +{"url": "https://essentialwholesale.com/optimsm-methylsulfonylmethane-usa", "date": "2023-03-27T01:21:04Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-14/segments/1679296946584.94/warc/CC-MAIN-20230326235016-20230327025016-00573.warc.gz", "language_score": 0.8969945311546326, "token_count": 443, "dump": "CC-MAIN-2023-14", "global_id": "webtext-fineweb__CC-MAIN-2023-14__0__144691536", "lang": "en", "text": "OptiMSM (MSM Methylsulfonylmethane USA)\nOptiMSM™, or methylsulfonylmethane (MSM), is an organic sulfur compound (34% sulfur) that is odorless, white, and flaky with a texture much like kosher salt. OptiMSM™ is easily soluble in water making it relatively simple to use in skincare formulations. The chemical formula of OptiMSM™ is CH3SO2CH3 Essential sources OptiMSM™ from the USA- the only GRAS-designated, non-GMO, gluten-free, allergen-free, non-shellfish-derived, vegan OptiMSM™ backed by extensive toxicology data.\nAn automatic surcharge, determined by UPS, will be charged to all pail orders due to special handling requirements.\n- Excellent ingredient for mature skin formulations\n- Helps to improve the appearance of aging skin.\n- Enhances effectiveness of other ingredients, making it a great choice in formulations using more costly ingredients\nAppearance: White, crystalline powder.\nAdd to the water phase of your cosmetic formulation. Heat to a minimum of 180 F.\nRecommended Usage Rate: 2% - 12%\nSolubility: Soluble in water.\nHow to Store: In a cool dry place in a tightly sealed container.\nWarnings: Pregnant or lactating people, or those with known medical conditions should consult with a physician prior to using product.\nINCI: Dimethyl Sulfone\nNot for internal consumption. For external use only.\nPregnant or lactating people or those with known medical conditions should consult with a physician prior to using product.\nPlease note that our suggested usage instructions are intended to serve as a guide. Due to the unique nature of each ingredient, it is important to always research and consult with a qualified professional as needed, prior to use. Usage guidelines can change and you are responsible for adhering to local regulations. EWL cannot be held responsible for any harm caused due to the misuse of these ingredients.", "domain": "chemistry", "round": 3} +{"url": "https://akjournals.com/search?access_0=all&f_0=author&pageSize=10&q_0=Zsolt+Bend%C5%91&sort=relevance&t=Medical", "date": "2021-09-19T02:39:01Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-39/segments/1631780056656.6/warc/CC-MAIN-20210919005057-20210919035057-00136.warc.gz", "language_score": 0.9658400416374207, "token_count": 297, "dump": "CC-MAIN-2021-39", "global_id": "webtext-fineweb__CC-MAIN-2021-39__0__196776193", "lang": "en", "text": "We investigated the effectiveness of chlorine dioxide (ClO2) solution in comparison to sodium hypochlorite (NaOCl) and chlorhexidine gluconate (CHX) in the elimination of intracanal Enterococcus faecalis biofilm. Extracted human teeth were inoculated with E. faecalis. After preparation the canals were irrigated with ClO2, NaOCl, CHX or physiologic saline for control. Two and five days later bacterial samples were collected and streaked onto Columbia agar. CFU/mL were counted. The canal walls were investigated by scanning electron microscopy (SEM). The gas phase was investigated in an upside down Petri dish where E. faecalis was inoculated onto blood agar. The irrigants were placed on absorbent paper into the cover. Bacteria were detectable in the control group, but not in any of the irrigants groups. There was a massive reinfection 2 or 5 days after irrigation in the control group. The lowest reinfection was found after the ClO2 treatment. These findings were confirmed by SEM images. We observed an antibacterial effect of ClO2 and NaOCl gas phases on E. faecalis growth, but not of CHX. ClO2 eliminates intracanal biofilm and keeps canal nearly free from bacteria. We suggest the use of high purity ClO2 as a root canal irrigant in clinical practice.", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/pin1-antibody-ab37891.html", "date": "2020-10-24T20:16:34Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-45/segments/1603107884755.46/warc/CC-MAIN-20201024194049-20201024224049-00475.warc.gz", "language_score": 0.7825952768325806, "token_count": 422, "dump": "CC-MAIN-2020-45", "global_id": "webtext-fineweb__CC-MAIN-2020-45__0__169780741", "lang": "en", "text": "Key features and details\n- Chicken polyclonal to Pin1\n- Suitable for: WB\n- Reacts with: Human\n- Isotype: IgY\nStorage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.\nStorage bufferConstituent: PBS\nConcentration information loading...\nPurityImmunogen affinity purified\nOur Abpromise guarantee covers the use of ab37891 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\n|WB||1/2000. Predicted molecular weight: 18 kDa.|\nFunctionEssential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Catalyzing pSer/Thr-Pro cis/trans isomerizations.\nSequence similaritiesContains 1 PpiC domain.\nContains 1 WW domain.\nDomainThe WW domain is required for the interaction with STIL and KIF20B.\nmodificationsPhosphorylated upon DNA damage, probably by ATM or ATR.\n- Information by UniProt\n- DOD antibody\n- DODO, Drosophila, homolog of antibody\n- FLJ40239 antibody\nAnti-Pin1 antibody (ab37891) at 1/2000 dilution + E coli-derived fusion protein\ngoat anti-IgY-HRP at 1/1000 dilution\nPredicted band size: 18 kDa\nObserved band size: 75 kDa why is the actual band size different from the predicted?\nThe difference between observed and expected MW is due to the fact that a fusion protein was used as positive control.\nab37891 has not yet been referenced specifically in any publications.", "domain": "chemistry", "round": 3} +{"url": "https://m.scirp.org/papers/25902", "date": "2020-02-25T19:42:46Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-10/segments/1581875146127.10/warc/CC-MAIN-20200225172036-20200225202036-00179.warc.gz", "language_score": 0.6673546433448792, "token_count": 4127, "dump": "CC-MAIN-2020-10", "global_id": "webtext-fineweb__CC-MAIN-2020-10__0__179516971", "lang": "en", "text": "ABSTRACT In the present work the synthesis of C60 produced in a conventional microwave oven from the decomposition of camphor resin is reported. The polycrystalline structure of the sample was determined by X-Ray Diffraction (XRD), the sample showed several phases, the main phase corresponds to fullerene C60 ordered in a Face-Centered Cubic structure (FCC), with two more structures: one orthorhombic system and the other the monoclinic system coexisting also with graphite 2H phase. It was observed in a Scanning Electron Microscopy (SEM), that the sample formed thin films of stacked carbon. Whereas in a High Resolution Transmission Electron Microscopy (HRTEM), measurements in Bright Field mode revealed that the main phase of the material is C60 ordered in FCC structure and the elemental composition and atomic bonding state can be determined by analyzing the energy with the electron microscope by Elesctron Energy- Loss Spectroscopy (EELS), technique allowed confirm all the phase C60 established with XRD observations.\nCite this paper\nJ. Martínez-Reyes, L. Barriga-Arceo, L. Rendón-Vazquez, R. Martínez-Guerrero, N. Romero-Partida, E. Palacios-González, V. Garibay-Febles and J. Ortiz-López, \"Microstructural Characterization of Large Area C60 Films Obtained by Conventional Microwave Oven Irradiation,\" World Journal of Nano Science and Engineering, Vol. 2 No. 4, 2012, pp. 213-218. doi: 10.4236/wjnse.2012.24029.\n S. M. Mominuzzaman, M. Rusop, T. Soa, T. Jimbo and M. Umeno, “Rearrangements of Hybridized Bonds in Nitrogen Incorporated Camphoric Carbon Thin Films Deposited by Pulsed Laser Ablation,” The 5th International Conference on Mechanical Engineering ICME 2003, Dhaka, 26-28 December 2003, pp. 1-4.\n C. Chen and Z. Lou, “Formation of C60 by Reduction of CO2,” The Journal of Supercritical Fluids, Vol. 50, No. 1, 2009, pp. 42-45. doi:10.1016/j.supflu.2009.04.008\n A. del V. Turina, M. V. Nolan, J. A. Zygadlo and M. A. Perillo, “Natural Terpenes: Self-Assembly and Membrane Partitioning,” Biophysical Chemistry, Vol. 122, No. 2, 2006, pp. 101-113.\n P. Louvieris, A. Gregoriades and W. Garn, “Assessing Critical Success Factors for Military Decision Support,” Expert Systems with Applications, Vol. 37, No. 12, 2010, pp. 8229-8241.\n A. H. Jayatissa, T. Gupta and A. D. Pandya, “Heating Effect on C60 Films during Microfabrication: Structure and Electrical Properties,” Carbon, Vol. 42, No. 5-6, 2004, pp. 1143-1146. doi:10.1016/j.carbon.2003.12.058\n T. D. Burchell, “Carbon Materials for Advanced Technologies,” Pergamon Press, New York, 1999, p. 85.\n A. G. Dall’ Asén, M. Verdier, H. Huck, E. B. Halac and M. Reinoso, “Nanoidentation on Carbon Thin Films Obtained from a C60 Ion Beam,” Applied Surface Science, Vol. 252, No. 22, 2006, pp. 8005-8009.\n R. F. Xiao, “Growth of Large Fullerene C60 Crystals and Highly Oriented Thin Films by Physical Vapor Transport,” Journal of Crystal Growth, Vol. 174, No. 1-4, 1997, pp. 821-827. doi:10.1016/S0022-0248(97)00051-1\n P. Milani, M. Ferretti, P. Piser, C. E. Bottani, A. Ferrari, A. Li Bassi, G. Guizzetti and M. Patrini, “Synthesis and Characterization of Cluster-Assembled Carbon Thin Films,” Journal of Applied Physics, Vol. 82, No. 11, 1997, pp. 5793-5798. doi:10.1063/1.366446\n M. Rusop, X. M. Tian, T. Kinugawa, T. Soga, T. Jimbo and M. Umeno, “Preparation and Characterization of Boron-Incorporated Amorphous Carbon Films from a Natural Source of Camphoric Carbon as a Precursor Material,” Applied Surface Science, Vol. 252, No. 5, 2005, pp. 1693- 1703. doi:10.1016/j.apsusc.2005.03.215\n T. Yim and S. Jones, “Growth Dynamics of C60 Thin Films: Effect of Molecular Structure,” Applied Physics Letters, Vol. 94, No. 2, 2009, pp. 021911-021913.\n B. D. Steinberg, E. A. Jackson, A. S. Filatov, A. Wakamiya, M. A. Petrukhina and L. T. Scott, “Aromatic ?- Systems More Curved than C60. The Complete Family of All Indenocorannulenes Synthesized by Iterative Microwave-Assisted Intramolecular Arylations,” Journal of the American Chemical Society, Vol. 131, No. 30, 2009, pp. 10537-10545. doi:10.1021/ja9031852\n A. Lew, P. O. Krutzik, M. E. Hart and A. R. Chamberlin, “Increasing Rates of Reaction: Microwave-Assisted Organic Synthesis for Combinatorial Chemistry,” Journal of Combinatorial Chemistry, Vol. 4, No. 2, 2002, pp. 95-105.\n S. M. Mominuzzaman, T. Soga, T. Jimbo and M. Umeno, “Camphoric Carbon Soot: A New Target for Deposition of Diamond-Like Carbon Films by Pulsed Laser Ablation,” Thin Solid Films, Vol. 376, No. 1-2, 2000, pp. 1-4.\n A. I. Oreshkin, R. Z. Bakhtizin, J. T. Sadowski and T. Sakurai, “Epitaxial Growth of C60 Thin Films on the Bi (0001)/Si(111) Surface,” Bulletin of the Russian Academy of Sciences: Physics, Vol. 73, No. 7, 2009, pp. 883- 885. doi:10.3103/S1062873809070065\n M. Rusop, T. Kinugawa, T. Soga and T. Jimbo, “Preparation and Microstructure Properties of Tetrahedral Amorphous Carbon Films by Pulsed Laser Deposition Using Camphoric Carbon Target,” Diamond and Related Materials, Vol. 13, No. 11-12, 2004, pp. 2174-2179.\n M. Kumar and Y. Ando, “Carbon Nanotubes from Camphor: An Environment-Friendly Nanotechnology,” Journal of Physics: Conference Series, Vol. 61, 2007, pp. 643- 646. doi:10.1088/1742-6596/61/1/129\n M. Kumar, T. Okazaki, M. Hiramatsu and Y. Ando, “The Use of Camphor-Grown Carbon Nanotube Array as an Efficient Field Emitter,” Carbon, Vol. 45, No. 9, 2007, pp. 1899-1904. doi:10.1016/j.carbon.2007.04.023\n P. R. Somani, S. P. Somani and M. Umeno, “Planer Nano- Graphenes from Camphor by CVD,” Chemical Physics Letters, Vol. 430, No. 1-3, 2006, pp. 56-59.\n S. M. Mominuzzaman, M. Rusop, T. Soga, T. Jimbo and M. Umeno, “Nitrogen Doping in Camphoric Carbon Films and Its Application to Photovoltaic Cell,” Solar Energy Materials and Solar Cells, Vol. 90, No. 18-19, 2006, pp. 3238-3243. doi:10.1016/j.solmat.2006.06.037\n C. O. Kappe and D. Dallinger, “Controlled Microwave Heating in Modern Organic Synthesis: Highlights from the 2004-2008 Literature,” Molecular Diversity, Vol. 13, No. 2, 2009, pp. 71-193. doi:10.1007/s11030-009-9138-8\n K. J. Rao, B. Vaidhyanathan, M. Ganguli and P. A. Ramakrishnan, “Synthesis of Inorganic Solids Using Microwaves,” Chemistry of Materials, Vol. 11, No. 4, 1999, pp. 882-895. doi:10.1021/cm9803859\n Committee on Microwave Processing of Materials: An Emerging Industrial Technology, Commission on Engineering and Technical Systems, National Research Council, “Microwave Processing of Materials,” Publication NMAB- 473, National Academy Press, Washington DC, 1994, pp. 1-149.\n A. Stadler, B. H. Yousefi, D. Dallinger, P. Walla, E. Van der Eycken, N. Kaval and C. O. Kappe, “Scability of Microwave-Assisted Organic Synthesis. From Single-Mode to Multimode Parallel Batch Reactors,” Organic Process Research & Development, Vol. 7, No. 5, 2003, pp. 707- 716. doi:10.1021/op034075+\n R. Martínez-Palou, “Microwave-Assisted Synthesis Using Ionic Liquids,” Molecular Diversity, Vol. 14, No. 1, 2010, pp. 3-25. doi:10.1007/s11030-009-9159-3\n G. Kalita, M. Masahiro, H. Uchida, K. Wakita and M. Umeno, “Few Layers of Graphene as Transparent Electrode from Botanical Derivate Camphor,” Materials Letters, Vol. 64, No. 20, 2010, pp. 2180-2183.\n S. Kar and S. Chaudhuri, “Optical Properties of Diamond Films Deposited by Low Temperature Microwave Plasma CVD from Camphor,” Materials Letters, Vol. 58, No. 24, 2004, pp. 3029-3033. doi:10.1016/j.matlet.2004.05.035\n N. R. Serebryanaya, “Reference Pattern Production for Superhard Pressure-Induced Phases of Fullerite C60,” International Center for Diffraction Data, Power Diffraction File (PDF-2), No. 49-1717.\n N. R. Serebryanaya, “Reference Pattern Production for Superhard Pressure-Induced Phases of Fullerite C60,” International Center for Diffraction Data, Power Diffraction File (PDF-2), No. 49-1718.\n M. Rusop, S. M. Mominuzzaman, T. Soga and T. Jimbo, “Properties of a-C:H Films Grown in Nert Gas Ambient with Camphoric Carbon Precursor of Pulsed Laser Deposition,” Diamond and Related Materials, Vol. 13, No. 11-12, 2004, pp. 2180-2186.\n D. Pradhan and M. Sharon, “Opto-Electrical Properties of Amorphous Carbon Thin Film Deposited from Natural Precursor Camphor,” Applied Surface Science, Vol. 253, No. 17, 2007, pp. 7004-7010.\n H.-B. Bürgi, R. Restori and D. Schwarzenbach, “Structure of C60: Partial Orientational Order in the Room- Temperature Modification of C60,” Acta Crystallographica Section B: Structural Science, Vol. 49, No. 5, 1993, pp. 832-838. doi:10.1107/S0108768193004008\n V. D. Blank, V. M. Levin, V. M. Prokhorov, G. A. Dubitskiy and N. Serebryanaya, “Elastic Properties of Ultrhard Fullerites,” Journal of Experimental and Theoretical Physics, Vol. 114, No. 4, 1998, pp. 1365-1374.\n R. Chen and P. Trucano, “Comparisons of Atomic Thermal Motions for Graphite at 300 K Based on X-Ray, Neutron, and Phonon-Spectrum Data,” Acta Crystallographica Section A: Crystal Physics, Diffraction, Theoretical and General Crystallography, Vol. 34, No. 6, 1978, pp. 979-982. doi:10.1107/S0567739478002004\n D. L. Dorset and M. P. McCourt, “Automated Structure Analysis in Electron Crystallography: Phase Determination with the Tangent Formula and Least-Squares Refinement,” Acta Crystallographica Section A: Foundations of Crystallography, Vol. 50, No. 3, 1994, pp. 287- 292.\n S. Adhikari, H. R. Aryal, D. C. Ghimire, G. Kalita and M. Umeno, “Optical Band Gap of Nitrogenated Amorphous Carbon Thin Films Synthesized by Microwave Surface Wave Plasma CVD,” Diamond and Related Materials, Vol. 17, No. 7-10, 2008, pp. 1666-1668.\n J. Bermúdez-Polonio, “Methods of X-Ray Diffraction: Principles and Applications,” Pirámide, Madrid, 1981, pp. 281-286.\n I. Rosales-Chávez, “Group-Subgroup Relations Crystallographic and Analysis Phase Transformations Induced Point Defects,” Doctoral Tesis, University of Mexico, UNAM, México City, 2008, pp. 2-204.\n M. St?hr, T. Wagner, M. Gabriel, B. Weyers and R. M?ller, “Binary Molecular Layers of C60 and Copper Phtalocyanine on Au (111): Self-Organized Nanostructuring,” Advanced Functional Materials, Vol. 1, No. 3, 2001, pp. 175- 178.\n W. F. Smith, “Fundamentals of Materials Science and Engineering,” 2nd Edition, McGraw-Hill, New York, 1993, p. 200.\n S. W. Ryu, C. J. Kim, S. Kim, M. Seo, C. Yun, S. Yoo and Y. K. Choi, “Fullerene-Derivate-Embedded Nanogap Field-Effect-Transistor and Its Nonvolatile Memory Application,” Small, Vol. 6, No. 15, 2010, pp. 1617-1621.\n T. K. Ishii, “Hanbook of Microwave Technology: Applications,” Academic Press, Cambridge, 1995, pp. 1-337.\n A. T. Ohns and D. F. Arne, “Engineers’ Handbook of Industrial Microwave Heating,” IET, London, 1998, pp. 1-232.\n D. Bogdal, “Microwave-Assisted Organic Synthesis: One Hundred Reaction Procedures,” Elsevier Science, Amsterdam, 2005, pp. 1-214.\n S. G. Buga, V. D. Blank, G. A. Dubitsky, N. R. Serebryanaya, A. Fransson, T. Wagberg and B. Sundqvist, “Synthesis of Superhard 3D-polymeric C60 Fullerites from Rhombohedral 2D-polymer by High-pressure-High-Temperature Treatment,” High Pressure Research, Vol. 23, No. 3, 2003, pp.259-264.\n K. Kohli, H. Chaudhary, P. Rathee, S. Rathee and V. Kumar, “Fullerenes: New Contour to Carbon Chemistry,” Pharma Times, Vol. 41, No. 2, 2009, pp. 9-12.\n “ICDD Grant-in-Aid,” International Centre for Diffraction Data Pcpdfwin, Moscow, 2010.\n D. Pradhan and M. Sharon, “Electrochemical Behavior of Amorphous Carbon Obtained from Camphor,” Electrochimica Acta, Vol. 50, No. 14, 2005, pp. 2905-2910.\n D. B. Williams and C. B. Carter, “Transmission Electron Microscopy: A Textbook for Materials Science,” 2nd Edition, Springer, New York, 2009, pp. 1-757.\n A. Goel, J. B. Howard and J. B. Vander Sande, “Size Analysis of Single Fullerene Molecules by Electron Microscopy,” Carbon, Vol. 42, No. 10, 2004, pp. 1907-1915.\n S. Jun-Yeo, R. Pode, J. Sun-Ahn and H. Min-Kim, “Study on the Size of Fullerene (C60) Aggregates in Solution by Photoluminescence and HRTEM Measurements,” Journal of the Korean Physical Society, Vol. 55, No. 1, 2009, pp. 322-326.\n L. A. Chernozatonskii, N. R. Serebryanaya and B. N. Mavrin, “The Superhard Crystalline Three-Dimensional Polymerized,” Chemical Physics Letters, Vol. 316, No. 3- 4, 2000, pp. 199-204.", "domain": "chemistry", "round": 3} +{"url": "https://www.frontiersin.org/research-topics/1654/unraveling-the-secrets-of-solute-transport", "date": "2021-03-07T09:23:25Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-10/segments/1614178376206.84/warc/CC-MAIN-20210307074942-20210307104942-00063.warc.gz", "language_score": 0.9296080470085144, "token_count": 700, "dump": "CC-MAIN-2021-10", "global_id": "webtext-fineweb__CC-MAIN-2021-10__0__175196024", "lang": "en", "text": "About this Research Topic\nIn this research topic we will present a survey about the current knowledge on solute transport proteins with special focus on the mitochondrial carrier family (MCF). We want to introduce the reader into the fascinating and sometimes very surprising results obtained from analyses concerning membrane proteins and transport processes.\nThe MCF is a large transporter family and members (one to more than 50) can be found in nearly all eukaryotic organisms from protists to higher plants and humans, whereas such proteins have never been detected in prokaryotic species. This observation supports the hypothesis that this prominent transporter family was newly invented slightly before or during establishment of the mitochondrial ancestor in the first eukaryotic cell. Various phylogenetically basal protists with rather ancient mitochondria-related organelles or mitochondrial derivatives (so called hydrogenosomes, mitosomes or anaerobic mitochondria) were shown to harbor MCF proteins. A common ancestral origin of recent MCF members is substantiated by phylogenetic analyses and reflected by their common basic structure. Generally, MCF proteins exhibit a molecular mass of about 30 – 35 kDa, they consist of six transmembrane domains composed of three repetitive regions with conserved amino acid motifs. Accordingly, each repeated domain comprises two transmembrane alpha-helices. Moreover, each loop connecting one odd-numbered with the following even-numbered helix exhibits a short amphipathic helical domain. Although MCF proteins are quite similar in structure, they are very heterogenous in terms of their biochemical properties and physiological function.\nMCF proteins mediate the transport of nearly all solutes shuttled across the inner mitochondrial membrane and represent carriers specific for diverse nucleotides, basic amino acids, di- and tricarboxylates, phosphate, for a broad variety of cofactors as well as uncoupling proteins, etc. The name might imply that MCF proteins are restricted to mitochondria (and mitochondria-related organelles). That, however, is not the whole story. Even though most MCF proteins are located in the inner mitochondrial membrane, recent studies detected more and more members also in other organelles, like the endoplasmic reticulum, peroxisomes and chloroplasts or in the plasma membrane. The functional properties of MCF proteins in other compartments than mitochondria appear to be more restricted because so far only carriers for adenine nucleotides or adenylated cofactors have been identified. Solute transport at the inner mitochondrial membrane is basically dominated by MCF proteins whereas solute transport of plastids, vacuoles, the plasma membrane, ER, or Golgi apparatus involves proteins from diverse families.\nHere we present an overview about structural and functional characteristics of solute transport proteins from different compartments and organisms. We highlight important key methods for investigation of membrane proteins and particularly refer to techniques applied for the analysis of solute transport. Diverse experts with long-term and short-term experience in membrane protein characterization summarize their scientific findings, share positive impressions and specify possible difficulties that might occur in transport protein analysis.\nImportant Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.", "domain": "chemistry", "round": 3} +{"url": "https://studysoup.com/tsg/416258/modern-chemistry-student-edition-2012-1-edition-chapter-9-problem-9-1-49", "date": "2019-11-17T06:53:46Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-47/segments/1573496668896.47/warc/CC-MAIN-20191117064703-20191117092703-00440.warc.gz", "language_score": 0.9260331988334656, "token_count": 280, "dump": "CC-MAIN-2019-47", "global_id": "webtext-fineweb__CC-MAIN-2019-47__0__114663446", "lang": "en", "text": "This full solution covers the following key subjects: . This expansive textbook survival guide covers 98 chapters, and 1789 solutions. Modern Chemistry: Student Edition 2012 was written by Patricia and is associated to the ISBN: 9780547586632. The full step-by-step solution to problem: 9.1.49 from chapter: 9 was answered by Patricia, our top Chemistry solution expert on 01/04/18, 09:13PM. Since the solution to 9.1.49 from 9 chapter was answered, more than 231 students have viewed the full step-by-step answer. This textbook survival guide was created for the textbook: Modern Chemistry: Student Edition 2012, edition: 1. The answer to “Gold can be recovered from sea water by reacting the water with zinc, which is refined from zinc oxide. The zinc displaces the gold in the water. What mass of gold can be recovered if 2.00 g of ZnO and an excess of sea water are available? 2ZnO(s) + C(s) 2Zn(s) + CO2(g) 2Au3+ (aq) + 3Zn(s) 3Zn2+(aq) + 2Au(s) CRITICAL THINKING 3” is broken down into a number of easy to follow steps, and 63 words.", "domain": "chemistry", "round": 3} +{"url": "https://medicalinnov.com/ab-catalyst/", "date": "2024-04-24T19:59:07Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712296819847.83/warc/CC-MAIN-20240424174709-20240424204709-00751.warc.gz", "language_score": 0.9133883118629456, "token_count": 337, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__127514391", "lang": "en", "text": "Humans are addicted to energy from fossil fuel. Developing nations, including India, do not have a choice but to depend on low cost energy from coal. But this energy comes at a huge environment cost. Coal burning generates greenhouse gases along with harmful pollution. Besides this, coal combustion depends on coal quality. Lower the quality, higher pollution and higher waste.\nWhilst we come up with total alternatives to fossil fuel, including coal, I3X has partnered with a specialized chemistry-based innovative company to greatly improve the combustion efficiency of coal in Power Plants, Cement Plants, Mining Equipment and other places where coal is used for thermal applications.\nAirborne Catalyst (ABC), founded by a Canadian scientist and entrepreneur, optimizes combustion conditions to reduce coal consumption while reducing greenhouse gases and ash content. ABC material lowers the ignition and carbon burnout temperature of coal allowing efficient heat generation in boilers.\nABC has decades of experience in improving coal combustion efficiency from 5 to 15%. ABC not only contributes in reducing pollution, greenhouse gases but also is accretive to our clients who get real bottom line impact by reducing total cost of ownership in generating heat from coal.\nAB Catalyst is efficient as – only 200 grams of catalyst is needed for every 1 ton of coal. It is eco-friendly, non-toxic, non-corrosive, and non-hazardous.\nThere is still time.\nSave our planet. Act now.\nIdeation3x Pte Ltd\n10 Cuscaden Walk,\nFour Seasons Park Singapore\nE : email@example.com\nP : +65 9186 2563", "domain": "chemistry", "round": 3} +{"url": "https://www.antibodies-online.com/antibody/3032188/anti-Peroxiredoxin+3+PRDX3+AA+239-256+antibody/", "date": "2023-02-07T07:29:16Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-06/segments/1674764500392.45/warc/CC-MAIN-20230207071302-20230207101302-00259.warc.gz", "language_score": 0.8216801285743713, "token_count": 269, "dump": "CC-MAIN-2023-06", "global_id": "webtext-fineweb__CC-MAIN-2023-06__0__249938356", "lang": "en", "text": "Titration of the Peroxiredoxin 3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL,Immunocytochemistry: 0.5-1 μg/mL\nFor Research Use only\n0.5 mg/mL if reconstituted with 0.2 mL sterile DI water\nThe lyophilized Peroxiredoxin 3 antibody can be stored at 4°C to -20°C. After reconstitution, aliquot and store at -20°C. Avoid repeated freezing and thawing.\nPeroxiredoxin 3 is a mitochondrial protein belonging to the AhpC/TSA family. Expression of PRDX3 is induced by MYC and is reduced in c-myc -/- cells. Chromatin immunoprecipitation analysis spanning the entire PRDX3 genomic sequence revealed that MYC binds preferentially to a 930-bp region surrounding exon 1. Results using mitochondria-specific fluorescent probes demonstrated that Peroxiredoxin 3 is essential for maintaining mitochondrial mass and membrane potential in transformed rat and human cells.", "domain": "chemistry", "round": 3} +{"url": "https://www.sdrdgw.com/2642/", "date": "2023-02-01T18:10:45Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-06/segments/1674764499949.24/warc/CC-MAIN-20230201180036-20230201210036-00363.warc.gz", "language_score": 0.9141209721565247, "token_count": 594, "dump": "CC-MAIN-2023-06", "global_id": "webtext-fineweb__CC-MAIN-2023-06__0__26637388", "lang": "en", "text": "The aluminum silicate fiberboard is processed by a wet vacuum forming process. Its strength is higher than that of vacuum forming felt, and it is more suitable for use in high temperature fields where the product has a higher rigidity and strength. Let us understand how to improve the flexural strength of aluminum silicate fiberboard:\nWhen we are studying chopped aluminum silicate fiberboard, we have carried out a certain analysis of the microscopic morphology of the fracture after bending and fracture of the reinforced silica sol shell. There are few fibers distributed on the fracture surface of the aluminum silicate fiberboard. The enhancement effect is not obvious, only 0.28MPa and 0.45MPa, an increase of about 12% to 19%. With the increase of fiber addition to 0.6% and 0.8%, the number of fibers on the surface of the aluminum silicate fiber fracture gradually increases, and its distribution in the shell is more uniform, indicating that the fiber has better dispersion in the coating preparation process, so participate The number of reinforcing fibers increases, thus showing an increase in the overall reinforcing effect.\nAt this time, the diameter of the fibers existing on the fracture surface of the product can be observed to decrease, which is caused by the elastic deformation in the process of fiber fracture and debonding. Continue to increase the amount of fiber added. From the fibers on the surface of the aluminum silicate fiber fracture, the residue of the mold shell can be observed, which shows that the aluminum silicate fiber effectively bears the load during the debonding process, which explains the experimental analysis The result is to help the aluminum silicate fiberboard to enhance the bending performance.\nThrough the above research, everyone should have some understanding of the use of aluminum silicate fiberboard. If you encounter any problems that cannot be solved in the process of using aluminum silicate fiberboard, you can consult us.\nFor more details or questions, please call the company hotline +0531 85800088 or through the online customer service website, you can also leave your contact information, we have professional technical personnel at any time for you to solve problems related to high temperature materials.\nSHANDONG REDON HIGH-TEMPERATURE MATERIAL Co. ,LTD. has the domestic advanced production equipment and leading production technology, with an annual output of 1050 ceramic fiber series products, 1260 ceramic fiber series products, 1400 ceramic fiber series products, 1600 polycrystalline series products tens of thousands of tons. With cotton, blankets, blanket, board, paper and all kinds of textiles, special-shaped products, modules, folding, castable, spraying, etc. Various forms of more than 30 kinds of products, can meet the insulation requirements of high temperature field under different conditions, welcome to have a friend need to click the website lower right online customer service or submit online enquiry, we will contact you the first time.", "domain": "chemistry", "round": 3} +{"url": "https://pubmed.ncbi.nlm.nih.gov/26433695/?dopt=Abstract", "date": "2021-10-25T04:51:52Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-43/segments/1634323587623.1/warc/CC-MAIN-20211025030510-20211025060510-00218.warc.gz", "language_score": 0.7746657133102417, "token_count": 326, "dump": "CC-MAIN-2021-43", "global_id": "webtext-fineweb__CC-MAIN-2021-43__0__255796814", "lang": "en", "text": "Pathogenic bacteria encode virulent glycosyltransferases that conjugate various glycans onto substrate proteins via the N- or O-linkage. The HMW system in nontypeable Haemophilus influenzae and the Pgl system in Campylobacter jejuni glycosylate bacterial surface or periplasmic proteins at the eukaryotic-like Asn-X-Ser/Thr motif. The NleB effector from enterobacteria mediates arginine GlcNAcylation of host death-domain proteins to block inflammation, representing an atypical N-glycosylation. The large clostridial cytotoxins and related glucosyltransferase toxins from Legionella and Photorhabdus monoglycosylate a serine/threonine or tyrosine in host Rho GTPase or elongation factor 1A (eEF1A). The emerging bacterial autotransporter heptosyltransferase (BAHT) family of heptosyltransferases also catalyses O-glycosylation and modifies autotransporters for adhesion to the host. These glycosylations, diverse in linkages and glycan structures, determine appropriate functioning of bacterial virulence factors or hijack host cellular processes in pathogenesis.\nKeywords: arginine GlcNAcylation; autotransporters; bacterial adhesion; heptosylation; inflammatory responses; protein glycosylation.\nCopyright © 2015 Elsevier Ltd. All rights reserved.", "domain": "chemistry", "round": 3} +{"url": "https://coek.info/pdf-crystal-structures-and-conducting-properties-of-ttm-ttp-salts-.html", "date": "2023-04-01T07:57:21Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-14/segments/1679296949701.56/warc/CC-MAIN-20230401063607-20230401093607-00573.warc.gz", "language_score": 0.8158453106880188, "token_count": 2517, "dump": "CC-MAIN-2023-14", "global_id": "webtext-fineweb__CC-MAIN-2023-14__0__18584648", "lang": "en", "text": "SL,?ATIITII[ IE=TBLLS I Synthetic Metals 70 (1995) 1153-1154\nCrystal structures and conducting properties of TTM-TTP salts Y. Misaki, a H. Nishikawa, a T. Yamabe, a T. Mori, b H. Mori c and S. Tanaka c aDivision of Molecular Engineering, Graduate school of Engineering, Kyoto University, Yoshida, Kyoto 606-01, J a p a n bDepartment of Organic and Polymeric Materials, Faculty of Engineering, Tokyo Institute of Technology, O-okayama, Tokyo 152, J a p a n CInternational Superconductivity Technology Center, Shinonome, Tokyo 135, J a p a n Abstract Conducting properties of various cation radical salts of the title donor have been investigated. Among them ( T T M - T T P ) I 3 and ~I-(TTM-TTP)2I 3 show metallic conductivity down to TMI = 160 and 20 K, respectively. The results of X-ray crystal structure analysis of (TTM-TTP)I 3 and (TTM-TTP)(PF6)0.267(THF)0. 6 are also presented. 1. I N T R O D U C T I O N A bis-fused TTF, 2,5-bis(1,3-dithiol-2-ylidene)1,3,4,6-tetrathiapentalene (BDT-TTP) and its derivatives are of considerable interest as a donor component for organic metals because several of them have afforded charge-transfer salts showing metallic conducting property down to low t e m p e r a t u r e (<4.2 K) [1,2]. In particular, several bis(methylthio) substituted BDT-TTPs have two-dimensional molecular arr a n g e m e n t , although the methylthio group has b e e n r e g a r d e d as an u n d e s i r a b l e s u b s t i t u e n t for realizing two-dimensional metals owing to the steric hindrance. In this Proceeding we report conducting properties of cation radical salts based on tetrakis(methylthio) derivative of BDT-TTP (TTM-TTP, depicted as below) and crystal s t r u c t u r e s o f ( T T M TTP)I 3 and (TTM-TTP)(PF6)0.267(THF)0. 6.\nMeST S~::~ST S~:=:~ST SMe MeSaS\nS.~ ~ ' . S\nTTM-TTP 2. C O N D U C T I N G P R O P E R T I E S Single crystals of TTM-TTP salts were prepared by electrochemical oxidation in the presence of the corresponding t e t r a b u t y l a m m o n i u m salts at a cons t a n t current of 0.3-0.5 9A in T H F or 1,1,2-trichloroe t h a n e (TCE). On the other hand, two 13 salts, (TTM-TTP)I 3, a - ( T T M - T T P ) 2 I 3 were obtained by diffusion technique with Bu4NI 3 in THF-TCE (1:1, v/v). The composition and conducting property of t h e m are s u m m a r i z e d in Table 1. Most of salts show semiconductive behavior, an.d3 their conductivity is relatively low values of 10\" -10 S cm- at room temperature. On the other hand, (TTM-TTP)I 3 and ~0379-6779/95/$09.50 © 1995 Elsevier Science S.A. All rights reserved 0379-6779(94)02797-3\n(TTM-TTP)2I 3 display_ exceptionally high conductivity of 700 and 200 S cm -1, respectively. Both salts are metallic down to 160 and 20 K, respectively, below of which become semiconductors. Whereas u - ( T T M TTP)2I 3 is a low conductive ( a r t = 0.03 S cm \"1) semiconductor with a large activation energy of 0.3 eV. 3. CRYTAL S T R U C T U R E S 3.1. (TTM-TTP)I 3 As shown in Figure 1, this salt has uniform columns of donor molecules , therefore, the calculated overlap of i n t r a s t a c k is a very large value of -26.1x10 -3. On the other hand, the interstack interaction is less t h a n 1/20 of the i n t r a s t a c k interaction because the effective overlap along the t r a n s v e r s e direction is prohibited owing to the steric hindrance of the methylthio groups t h a t are b e n t toward the outside from the molecular plane. It seems to be surprising t h a t the present salt shows metallic conductivity in spite of 1:1 salt. However, it has one donor molecule in a unit cell, therefore there exists only one (half-filled) energy band, which m a y result in metallic conduction. F u r t h e r m o r e , the reduced onsite Coulomb repulsion and the c o m p a r a t i v e l y large bandwidth (ca. 1 eV) probably avoid the formation of a Mott-insulator .\nFigure 1. Donor a r r a n g e m e n t of (TTM-TTP)I 3.\nY. Misaki et aL / Synthetic Metals 70 (1995) 1153-1154\nTable 1. Composition and Electrical Conductivity of (TTM-TTP)Ax Anion\nC104 C104 ReO4 IO4 PF 6 PF 6 AsF 6 AsF 6 I3 I3 (a) 13 (~) AuC12 AuBr2\nTCE b') THF TCE TCE TCE THF TCE TCE TCE-THF TCE-THF TCE THF THF\nplate needle plate plate plate plate needle plate needle plate needle needle needle\n0.8(Re) 0.8(I) 0.267(X) 1.2(As) 0.9(As) 1.0(X) 0.5(X) 0.54(I) 0.15(Au) 0.9(Au), 0.7(Br)\nOrt / Scm \"1\n2 0.8 19 0.34 0.01 0.003 2.4 0.2 600 0.03 200 1.2 0.6\n0.1 0.05 0.07 0.1 0.22 0.14 0.05 0.2 TMI = 160 K 0.3 TM! = 20 K 0.03 0.086\na) Determined by the energy dispersion spectroscopy from the ratio of sulfur and the elements designated in the parentheses. X designates the value determined from the single crystal X-ray structure analysis, b) TCE = 1,1,2-trichloroethane. 3.2. (TTM-TTP) (PF6)0.267 (THF)0. 6 There are three of crystallographically independent donor molecules (molecules A, B and C) . The molecule C lies on a center of inversion, and the others are located on general positions. The crystal contains two i n d e p e n d e n t T H F molecules. TTM-TTP molecules form conducting sheets along ac plane, which are sandwiched by anion sheets composed of PF6 anions and T H F molecules. The donor molecules are stacking along direction with fivefold period as A-B-C-B-A (Figure 2). Contrary to (TTM-TTP)I 3, the present salt has two-dimensional a r r a n g e m e n t of donors. All of the overlap modes of donors are the ring-over-bond type-(Figure 3). The angles between the molecular planes and the direction of the int r a s t a c k interaction are 90 ° for molecules A-B and 60 ° for A-A' and B-C. The overlap between molecules A and B (b2 ,= -25.1x10\"~) i s a b o u t six times as l a r g e s s those of A-A (bl = -4.2x10 -3) and B-C (b3 = 4.1x10\"3), resulting in strongly dimerized structure in the stack. On the other hand, the overlaps along the transverse direction are comparatively large (5.8-6.9x10\") and the donors a r r a y uniformly along the t r a n s v e r s e direction, therefore, the electronic s t r u c t u r e of this salt is expected to be one-dimensional along c-axis. C\nF i g u r e 2. D o n o r a r r a n g e m e n t TTP)(PF6)0.267(THF)0.6\nFigure 3. Overlap modes of intrastack donors in (TTM-TTP)(PF6)0.267(THF)0.6\n1. Y. Misaki et al., Chem. Lett. (1993) 729; 2073; in press; J. Chem. Soc., Chem. Commun. (1994) 459; T. Mori et al., Bull. Chem. Soc., Jpn. in press. 2. T. Mori et al., Chem. Lett. (1993) 733; (1993) 2085. 3. T. Mori et al., Bull. Chem. Soc., Jpn. 67 (1994) 661. 4. C r y s t a l data: Triclinic, space group P - 1 , a = 11.225(3) b = 11.867(3), c = 5.788(1) A, a = 99~69(2), fl = 102.36(2), 7= 112.22(2) °, V = 670.2(3)/k 3, R = 0.047 using 1851 independent reflections ([Fol > 3o(F)). 5. Cyclic v o l t a m m e t r y reveals t h a t E 2 - E 1 value of TTM-TTP is a b o u t two-thirds of TTM-TTF: Y. Misaki et al., Chem. Lett. (1992) 2321. 6. Crystal data: Triclinic, space group P 1, a = 17.900(8) b = 20.336(8), c =o9.79(1) A, a = 82J6(6), fl = 104.44(6), 7 = 111.10(3) , V = 3219(64) ]k3, R = 0.104 using 3351 independent reflections ( I F o l > 3o(F)).", "domain": "chemistry", "round": 3} +{"url": "https://insights.ovid.com/eujoph/200812030/00003656-200812030-00003", "date": "2018-11-19T07:16:09Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-47/segments/1542039745486.91/warc/CC-MAIN-20181119064334-20181119090334-00103.warc.gz", "language_score": 0.9049614071846008, "token_count": 451, "dump": "CC-MAIN-2018-47", "global_id": "webtext-fineweb__CC-MAIN-2018-47__0__17788069", "lang": "en", "text": "Agmatine, an endogenous ligand for imidazoline I1 receptor, has previously been shown to prevent opioid tolerance in rats and mice, but the cellular mechanisms remain unknown. In the present study, the effects of agmatine activation on imidazoline I1 receptor on the desensitization, down-regulation and internalization of μ opioid receptor were investigated. Two cell lines, CHO cells transfected μ opioid receptor (CHO-μ cells) and co-transfected μ opioid receptor and imidazoline I1 receptor antisera-selected protein (IRAS) (CHO-μ/IRAS cells), were used. In both CHO-μ cells and CHO-μ/IRAS cells, agmatine (0.01–10 μM) did not affect the desensitization of μ opioid receptor induced by [d-Ala2, N-Me-Phe4,Gly5-ol]-enkephalin (DAMGO) (10 μM) treatment for 30 min. However, agmatine (0.1–100 nM) co-pretreatment with DAMGO (1 μM) for 12 h concentration-dependently inhibited DAMGO-induced down-regulation of μ opioid receptor in CHO-μ/IRAS cells, but not in CHO-μ cells. Efaroxan, the I1/α2-adrenoceptors mix antagonist, completely reversed the inhibitory effect of agmatine, suggesting the participation of imidazoline I1 receptor. In addition, agmatine (1–100 nM) inhibited DAMGO-induced internalization of μ opioid receptor in CHO-μ/IRAS cells, which was reversed by efaroxan as well. While treatment with DAMGO (1 μM) or co-treatment with agmatine (1–100 nM) for 12 h failed to affect the mRNA level of μ opioid receptor. Taken together, these results indicate that the inhibitory effect of agmatine on tolerance in vitro might be related to attenuation of the internalization and down-regulation of μ opioid receptor via activation of imidazoline I1 receptor.", "domain": "chemistry", "round": 3} +{"url": "https://insights.ovid.com/febsj/200906180/01217111-200906180-00009", "date": "2019-01-17T09:29:37Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-04/segments/1547583658901.41/warc/CC-MAIN-20190117082302-20190117104302-00148.warc.gz", "language_score": 0.9644579291343689, "token_count": 412, "dump": "CC-MAIN-2019-04", "global_id": "webtext-fineweb__CC-MAIN-2019-04__0__158313873", "lang": "en", "text": "Thrombin generation increases in several pathological conditions, including cancer, thromboembolism, diabetes and myeloproliferative syndromes. During tumor development, thrombin levels increase along with several other molecules, including cytokines and angiogenic factors. Under such conditions, it is reasonable to predict that thrombin may recognize new low-affinity substrates that usually are not recognized under low-expression levels conditions. In the present study, we hypothesized that fibroblast growth factor (FGF)-2 may be cleaved by thrombin and that such action may lead to an impairment of its biological activity. The evidence collected in the present study indicates that FGF-2-induced proliferation and chemotaxis/invasion of SK-MEL-110 human melanoma cells were significantly reduced when FGF-2 was pre-incubated with active thrombin. The inhibition of proliferation was not influenced by heparin. Phe-Pro-Arg-chloromethyl ketone, a specific inhibitor of the enzymatic activity of thrombin, abolished the thrombin-induced observed effects. Accordingly, both FGF-2-binding to cell membranes as well as FGF-2-induced extracellular signal-regulated kinase phosphorylation were decreased in the presence of thrombin. Finally, HPLC analyses demonstrated that FGF-2 is cleaved by thrombin at the peptide bond between residues Arg42 and Ile43 of the mature human FGF-2 sequence. The apparent kcat/Km of FGF-2 hydrolysis was 1.1 × 104 M−1·s−1, which is comparable to other known low-affinity thrombin substrates. Taken together, these results demonstrate that thrombin digests FGF-2 at the site Arg42-Ile43 and impairs FGF-2 activity in vitro, indicating that FGF-2 is a novel thrombin substrate.", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/netrin-g1-antibody-ab153834.html", "date": "2020-07-09T20:36:00Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-29/segments/1593655901509.58/warc/CC-MAIN-20200709193741-20200709223741-00250.warc.gz", "language_score": 0.6872409582138062, "token_count": 370, "dump": "CC-MAIN-2020-29", "global_id": "webtext-fineweb__CC-MAIN-2020-29__0__113001388", "lang": "en", "text": "Key features and details\n- Rabbit polyclonal to Netrin G1\n- Suitable for: WB\n- Reacts with: Mouse, Human\n- Isotype: IgG\nProduct nameAnti-Netrin G1 antibody\nSee all Netrin G1 primary antibodies\nDescriptionRabbit polyclonal to Netrin G1\nTested applicationsSuitable for: WBmore details\nSpecies reactivityReacts with: Mouse, Human\nPredicted to work with: Rat\nRecombinant fragment, corresponding to a region within internal sequence amino acids 122-354 of Human Netrin G1 (Q9Y2I2)\n- HeLa, HCT116 cells; HepG2 whole cell lysate, mouse brain whole cell lysate.\nStorage instructionsShipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.\nStorage bufferpH: 7.00\nPreservative: 0.01% Thimerosal (merthiolate)\nConstituents: 1.21% Tris, 0.75% Glycine, 20% Glycerol\nConcentration information loading...\nPurityImmunogen affinity purified\nOur Abpromise guarantee covers the use of ab153834 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\n|WB||1/500 - 1/3000. Predicted molecular weight: 60 kDa.|\n- Information by UniProt\n- Axon guidance molecule antibody\n- KIAA0976 antibody\n- Laminet 1 antibody\nab153834 has not yet been referenced specifically in any publications.", "domain": "chemistry", "round": 3} +{"url": "https://www.mdpi.com/1420-3049/22/7/1119", "date": "2019-01-22T15:20:33Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-04/segments/1547583857913.57/warc/CC-MAIN-20190122140606-20190122162606-00361.warc.gz", "language_score": 0.8693447113037109, "token_count": 578, "dump": "CC-MAIN-2019-04", "global_id": "webtext-fineweb__CC-MAIN-2019-04__0__130607007", "lang": "en", "text": "Prediction of Drug–Target Interaction Networks from the Integration of Protein Sequences and Drug Chemical Structures\nAbstractKnowledge of drug–target interaction (DTI) plays an important role in discovering new drug candidates. Unfortunately, there are unavoidable shortcomings; including the time-consuming and expensive nature of the experimental method to predict DTI. Therefore, it motivates us to develop an effective computational method to predict DTI based on protein sequence. In the paper, we proposed a novel computational approach based on protein sequence, namely PDTPS (Predicting Drug Targets with Protein Sequence) to predict DTI. The PDTPS method combines Bi-gram probabilities (BIGP), Position Specific Scoring Matrix (PSSM), and Principal Component Analysis (PCA) with Relevance Vector Machine (RVM). In order to evaluate the prediction capacity of the PDTPS, the experiment was carried out on enzyme, ion channel, GPCR, and nuclear receptor datasets by using five-fold cross-validation tests. The proposed PDTPS method achieved average accuracy of 97.73%, 93.12%, 86.78%, and 87.78% on enzyme, ion channel, GPCR and nuclear receptor datasets, respectively. The experimental results showed that our method has good prediction performance. Furthermore, in order to further evaluate the prediction performance of the proposed PDTPS method, we compared it with the state-of-the-art support vector machine (SVM) classifier on enzyme and ion channel datasets, and other exiting methods on four datasets. The promising comparison results further demonstrate that the efficiency and robust of the proposed PDTPS method. This makes it a useful tool and suitable for predicting DTI, as well as other bioinformatics tasks. View Full-Text\nShare & Cite This Article\nMeng, F.-R.; You, Z.-H.; Chen, X.; Zhou, Y.; An, J.-Y. Prediction of Drug–Target Interaction Networks from the Integration of Protein Sequences and Drug Chemical Structures. Molecules 2017, 22, 1119.\nMeng F-R, You Z-H, Chen X, Zhou Y, An J-Y. Prediction of Drug–Target Interaction Networks from the Integration of Protein Sequences and Drug Chemical Structures. Molecules. 2017; 22(7):1119.Chicago/Turabian Style\nMeng, Fan-Rong; You, Zhu-Hong; Chen, Xing; Zhou, Yong; An, Ji-Yong. 2017. \"Prediction of Drug–Target Interaction Networks from the Integration of Protein Sequences and Drug Chemical Structures.\" Molecules 22, no. 7: 1119.\nNote that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.", "domain": "chemistry", "round": 3} +{"url": "http://www.antikoerper-online.de/intracellular-steroid-hormone-receptor-signaling-pathway-pathway-34/ncoa1-elisa-kit-1430/", "date": "2018-01-24T11:48:09Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-05/segments/1516084894125.99/warc/CC-MAIN-20180124105939-20180124125939-00631.warc.gz", "language_score": 0.7770448327064514, "token_count": 2148, "dump": "CC-MAIN-2018-05", "global_id": "webtext-fineweb__CC-MAIN-2018-05__0__239173723", "lang": "en", "text": "Use your antibodies-online credentials, if available.\nKeine Produkte auf Ihrer Vergleichsliste.\nIhr Warenkorb ist leer.\nAlle Spezies anzeigen\nWeitere Synonyme anzeigen\nSelect your species\nThe structural and functional competency of the UPIII (zeige UPK3A ELISA Kits)-Src (zeige SRC ELISA Kits) signaling system in membrane microdomains is strictly regulated during oocyte maturation.\nSRC-1 (zeige SRC ELISA Kits) can impact osteoblast function in an estrogen receptor (zeige ESR1 ELISA Kits)-independent manner.\nThe pregnane X receptor (zeige NR1I2 ELISA Kits) down-regulates organic cation transporter 1 (SLC22A1) in human hepatocytes by competing for (\"squelching\") SRC-1 (zeige SRC ELISA Kits) coactivator.\nmiR (zeige MLXIP ELISA Kits)-4443 acts in a tumor-suppressive manner by down-regulating TRAF4 (zeige TRAF4 ELISA Kits) and NCOA1 downstream of MEK (zeige MAP2K1 ELISA Kits)-C/EBP (zeige CEBPA ELISA Kits)-mediated leptin (zeige LEP ELISA Kits) and insulin (zeige INS ELISA Kits) signaling, and that insulin (zeige INS ELISA Kits) and/or leptin (zeige LEP ELISA Kits) resistance (e.g. in obesity) may suppress this pathway and increase the risk of metastatic CRC (zeige CALR ELISA Kits).\nResults provide the first evidence that NCOA1 is a direct target of miR (zeige MLXIP ELISA Kits)-105-1 suggesting that NCOA1 and miR (zeige MLXIP ELISA Kits)-105-1 may have potential prognostic value and may be useful as tumor biomarkers for the diagnosis of HCC (zeige FAM126A ELISA Kits) patients.\nData suggest that steroid receptor (zeige ESR2 ELISA Kits) coactivators (NCOA1, NCOA2 (zeige NCOA2 ELISA Kits), NCOA3 (zeige NCOA3 ELISA Kits)) are over-expressed in a number of hormone-dependent cancers where they promote tumor growth, invasion, metastasis, and chemo-resistance; with their multiple roles in cancer, steroid receptor (zeige ESR2 ELISA Kits) coactivators are promising targets for development of antineoplastic agents that can interfere with their function. [REVIEW]\nThe mechanism of IL-6-induced AR activation is mediated through enhancing AR-SRC-1 interaction and inhibiting AR-SMRT interaction.\nIL-6-mediated AR antagonism induced by cypermethrin is related to repress the recruitment of co-regulators SRC-1 and SMRT to the AR in a ligand-independent manner\nNCOA1 potentiates breast cancer angiogenesis through upregulating HIF1alpha (zeige HIF1A ELISA Kits) and AP-1 (zeige FOSB ELISA Kits)-mediated VEGFa (zeige VEGFA ELISA Kits) expression\nmiR (zeige MLXIP ELISA Kits)-137 has a role in targeting p160 (zeige MSH6 ELISA Kits) steroid receptor (zeige ESR2 ELISA Kits) coactivators SRC1 (zeige SRC ELISA Kits), SRC2 (zeige NCOA2 ELISA Kits), and SRC3 (zeige NCOA3 ELISA Kits) and inhibits cell proliferation\nReport novel PAX3 (zeige PAX3 ELISA Kits)-NCOA1 gene fusions in biphenotypic sinonasal sarcomas with focal rhabdomyoblastic differentiation.\nSRC-1 can impact osteoblast function in an estrogen receptor (zeige ESR1 ELISA Kits)-independent manner.\nThe results suggest that biochanin A activates RORgamma-dependent IL-17 (zeige IL17A ELISA Kits) transcription through the enhancement of STAT3 (zeige STAT3 ELISA Kits) phosphorylation and STAT3 (zeige STAT3 ELISA Kits)-mediated recruitment of NCOA1 to RORgamma.\nubiquitination of K446 limits RORgammat-mediated Th17 differentiation by inhibiting the recruitment of coactivator SRC1\nLoss of SRC-1 is associated with high Blood Pressure and Aortic Stiffness.\nlocal E2 inhibition could induce aberrant actin polymerization and also showed an important role of SRC-1 in the mediation of local E2 action on hippocampal synaptic plasticity by regulation of actin cytoskeleton dynamics\nSRC-1/3 are required for cardiomyocyte proliferation and differentiation at earlier developmental stages, and their dysfunction causes NCC (zeige SLC12A3 ELISA Kits)-like abnormalities in the hearts of newborn and adult mice.\nWhile hippocampal SRC-1 was significantly downregulated by orchidectomy (ORX), its expression was rescued by treatment with testosterone in a dose-dependent manner. Testosterone regulates synaptic proteins involves AR, estrogen receptors and SRC-1.\nfetal lungs produce signals to initiate labor when mature, and SRC-1/-2-dependent production of SP-A (zeige SFTPA1 ELISA Kits) and PAF (zeige KIAA0101 ELISA Kits) is crucial for this process\nConsequently, SRC-1 null mice displayed low TAT (zeige TAT ELISA Kits) expression and presented with hypertyrosinemia and corneal alterations, 2 clinical features observed in the human syndrome of TAT (zeige TAT ELISA Kits) deficiency.\nthe effect of orchidectomy (ORX) on the expression of SRC-1\nwe cloned and sequenced full length cDNA of NCOA-1 gene in pig. The putative protein includes 1440 amino acids. Sequences alignment showed that pig NCOA-1 gene cDNA sequence has identity of 93.73% with human and mouse.\nSrc64 controls actin dynamics to mediate proper ring canal formation during incomplete cytokinesis during germline cyst development in vivo\nthat Brat represses the translation of src64B, an upstream regulator of a conserved Rho-dependent pathway previously shown to promote axon retraction\nResults show that Src42a and Src64b are required for the normal division capacity of Drosophila intestinal progenitor cells, and that these genes as well as Ack cause progenitor overproliferation in the intestine via core cell cycle activation.\na novel essential role for Src (zeige SRC ELISA Kits) in intestinal stem/progenitor cell proliferation and tumourigenesis initiation in vivo.\nData show that the actin-Capping Protein (zeige TMOD4 ELISA Kits) (CP) alphabeta heterodimer, which regulates actin (zeige ACTB ELISA Kits) filament (F-actin (zeige ACTB ELISA Kits)) polymerization, limits Src (zeige SRC ELISA Kits)-induced apoptosis or tissue overgrowth by restricting JNK (zeige MAPK8 ELISA Kits) activation.\nDumbfounded/Neph1 (zeige NEPH1 ELISA Kits), a key diaphragm constituent, is a target of the Src kinase (zeige CSK ELISA Kits) Src64B. Loss of Src64B activity leads to a reduction in the number of diaphragms, and this effect is in part mediated by loss of Dumbfounded/Neph1 (zeige NEPH1 ELISA Kits) tyrosine phosphorylation.\nHomodimerization of the Wnt receptor DERAILED recruits the Src (zeige SRC ELISA Kits) family kinase SRC64B in the developing embryonic central nervous system.\nE4orf4 has a role in inducing PP2A- and Src (zeige SRC ELISA Kits)-dependent cell death while inhibiting classic apoptosis pathways in Drosophila melanogaster\nMutations in a Drosophila src gene, src64, that alter the three HRD amino acids, were identified.\nSrc64B overexpression induced the formation of specialized haemocytes (lamellocytes), but had no effect on circulating plasmatocyte concentration. Src64B overexpression induced F-actin (zeige ACTB ELISA Kits) formation and Jun kinase (zeige MAPK9 ELISA Kits) activation in plasmatocytes.\nThe protein encoded by this gene acts as a transcriptional coactivator for steroid and nuclear hormone receptors. It is a member of the p160/steroid receptor coactivator (SRC) family and like other family members has histone acetyltransferase activity and contains a nuclear localization signal, as well as bHLH and PAS domains. The product of this gene binds nuclear receptors directly and stimulates the transcriptional activities in a hormone-dependent fashion. Alternatively spliced transcript variants encoding different isoforms have been identified.\nnuclear receptor coactivator 1\n, steroid receptor RNA activator 1\n, Hin-2 protein\n, PAX3/NCOA1 fusion protein\n, class E basic helix-loop-helix protein 74\n, renal carcinoma antigen NY-REN-52\n, steroid receptor coactivator-1\n, nuclear receptor coactivator protein 1\n, steroid receptor coactivator 1\n, Src proto oncogene sequence\n, mRNA-like ncRNA in embryogenesis 5\n, tyrosine protein kinase pp60-c-src\n, tyrosine-protein kinase Src-2\n, v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog", "domain": "chemistry", "round": 3} +{"url": "https://esrj.sbu.ac.ir/article_96430.html", "date": "2024-04-17T02:41:39Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712296817128.7/warc/CC-MAIN-20240417013540-20240417043540-00656.warc.gz", "language_score": 0.8759346008300781, "token_count": 534, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__95018551", "lang": "en", "text": "عنوان مقاله [English]\nThe Senj Cu-Mo deposit is located in the central part of the Alborz Magmatic Arc (AMA), northern Alborz province (Karaj). Geology of the Senj area composed of mafic to intermediate Tertiary intrusive rocks and various types of volcaniclastic rocks. The early stage volcaniclastic rocks of Karaj Formation were intruded by the Oligocene Karaj Dam basement sill (composed of monzogabbro, monzodiorite and diorite) and Cu-Mo (±Ag and Au) mineralization occurred in contact of this rocks. Ore minerals such as sulfides (chalcopyrite, bornite, molybdenite, and pyrite), oxides (magnetite and hematite), and carbonates (malachite and azurite) are the main mineralogical paragenesis in the area. Stockwork quartz-sulfide mineralization as the richest part of ore body have average grade of 3.0 wt% Cu and 0.2 wt% Mo occur in porphyritic tuff host rock with potassic-phyllic alteration. The disseminated mineralization consist of chalcopyrite and molybdenite disseminated minerals with average grade of 1.8 wt% Cu and 0.1 wt% Mo occur in the porphyritic andesite tuff and intermediate argillic alteration. The supergene enrichment zone with limited exposure is composed of oxide-hydroxide upper ore with low grade Cu mineralization and sulfidation replacement lower ore zone with highest grade of 2.8 wt% Cu. The magnetite-biotite (K-silicate), potassic-phyllic (K-feldsapr-biotite-sericite-quartz±pyrite), intermediate argillic (kaolinite-illite±quartz±calcite) and propylitic (epidote-chlorite-laumontite-calcite±pyrite) are the main alteration assemblages related to mineral deposit. Based on geochemistry of alteration assemblages, the highest concentration of Cu and Mo mineralized elements occurred in the potassic-phyllic alteration and the intermediate argillic alteration and propylitic alteration have lower ore grade.", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/rabbit-bottlenose-dolphin-igg-hl-hrp-ab112789.html", "date": "2020-09-30T21:56:10Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-40/segments/1600402128649.98/warc/CC-MAIN-20200930204041-20200930234041-00043.warc.gz", "language_score": 0.6835833191871643, "token_count": 547, "dump": "CC-MAIN-2020-40", "global_id": "webtext-fineweb__CC-MAIN-2020-40__0__180742362", "lang": "en", "text": "Key features and details\n- Rabbit Anti-Bottlenose Dolphin IgG H&L (HRP)\n- Conjugation: HRP\n- Host species: Rabbit\n- Isotype: IgG\n- Suitable for: WB, ELISA, ICC, IHC-P\nProduct nameRabbit Anti-Bottlenose Dolphin IgG H&L (HRP)\nSee all IgG secondary antibodies\nTarget speciesBottlenose dolphin\nSpecificitythis antibody reacts specifically with bottlenose dolphin IgG and with light chains common to other bottlenose dolphin immunoglobulins.\nTested applicationsSuitable for: WB, ELISA, ICC, IHC-Pmore details\nStorage instructionsShipped at 4°C. Store at +4°C.\nStorage bufferConstituents: 0.2% BSA, 0.05% CMIT/MIT based preservative\nConcentration information loading...\nPurityImmunogen affinity purified\n- TMB ELISA Substrate (Highest Sensitivity) (ab171522)\n- TMB ELISA Substrate (High Sensitivity) (ab171523)\n- TMB ELISA Substrate (Fast Kinetic Rate) (ab171524)\n- TMB ELISA Substrate (Slow Kinetic Rate) (ab171525)\n- TMB ELISA Substrate (Slower Kinetic Rate) (ab171526)\n- TMB ELISA Substrate (Slowest Kinetic Rate) (ab171527)\nOur Abpromise guarantee covers the use of ab112789 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\n|WB||1/1000 - 1/10000. with Colorimetric detection. Use at 1/1000 - 1/30000 with Chemiluminescent detection.|\n|ELISA||1/10000 - 1/100000.|\n|ICC||1/200 - 1/500.|\n|IHC-P||1/200 - 1/500.|\nTo our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.\nab112789 has been referenced in 1 publication.\n- Woo PC et al. Discovery of a novel bottlenose dolphin coronavirus reveals a distinct species of marine mammal coronavirus in Gammacoronavirus. J Virol 88:1318-31 (2014). PubMed: 24227844", "domain": "chemistry", "round": 3} +{"url": "https://utsouthwestern.pure.elsevier.com/en/publications/specificity-of-memapsin-1-and-its-implications-on-the-design-of-m", "date": "2022-08-17T01:22:15Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882572833.78/warc/CC-MAIN-20220817001643-20220817031643-00253.warc.gz", "language_score": 0.8826488256454468, "token_count": 351, "dump": "CC-MAIN-2022-33", "global_id": "webtext-fineweb__CC-MAIN-2022-33__0__53275725", "lang": "en", "text": "Memapsin 1 is closely homologous to memapsin 2 (BACE), or β-secretase, whose action on β-amyloid precursor protein (APP) leads to the production of β-amyloid (Aβ) peptide and the progression of Alzheimer's disease. Memapsin 2 is a current target for the development of inhibitor drugs to treat Alzheimer's disease. Although memapsin 1 hydrolyzes the β-secretase site of APP, it is not significantly present in the brain, and no direct evidence links it to Alzheimer's disease. We report here the residue specificity of eight memapsin 1 subsites. In substrate positions P4, P3, P2, P1, P1', P2', P3', and P4', the most preferred residues are Glu, Leu, Asn, Phe, Met, Ile, Phe, and Trp, respectively, while the second preferred residues are Gln, Ile, Asp, Leu, Leu, Val, Trp, and Phe, respectively. Other less preferred residues can also be accommodated in these subsites of memapsin 1. Despite the broad specificity, these residue preferences are strikingly similar to those of human memapsin 2 [Turner et al. (2001) Biochemistry 40, 10001-10006] and thus pose a serious problem to the design of differentially selective inhibitors capable of inhibiting memapsin 2. This difficulty was confirmed by the finding that several potent memapsin 2 inhibitors effectively inhibited memapsin 1 as well. Several possible approaches to overcome this problem are discussed.\nASJC Scopus subject areas", "domain": "chemistry", "round": 3} +{"url": "http://www.yeastgenome.org/reference/S000143084/overview", "date": "2014-03-08T11:33:19Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2014-10/segments/1393999654390/warc/CC-MAIN-20140305060734-00055-ip-10-183-142-35.ec2.internal.warc.gz", "language_score": 0.8072656989097595, "token_count": 492, "dump": "CC-MAIN-2014-10", "global_id": "webtext-fineweb__CC-MAIN-2014-10__0__206926913", "lang": "en", "text": "Bakers yeast (Saccharomyces cerevisiae) whole-cell bioconversions of naringenin 7-O-beta- glucoside revealed considerable beta-glucosidase activity which impairs any strategy to generate or modify flavonoid glucosides in yeast transformants. Up to ten putative glycoside hydrolases annotated in the S. cerevisiae genome database were overexpressed with His-tags in yeast cells. Examination of these recombinant, partially purified polypeptides for hydrolytic activity with synthetic chromogenic alpha- or beta-glucosides identified three efficient beta-glucosidases (EXG1, SPR1 and YIR007W) which were further assayed with natural flavonoid beta-glucoside substrates and product verification by TLC or HPLC. Preferential hydrolysis of 7- or 4'-O-glucosides of isoflavones, flavonols, flavones and flavanones was observed in vitro with all three glucosidases, while anthocyanins were also accepted as substrates. The glucosidase activities of EXG1 or SPR1 were completely abolished by Val168Tyr mutation, which confirmed the relevance of this residue as reported for other glucosidases. Most importantly, biotransformation experiments with knock-out yeast strains revealed that solely EXG1 knock-out strains lost the capability of hydrolyzing flavonoid glucosides.\n|Evidence ID||Analyze ID||Interactor||Interactor Systematic Name||Interactor||Interactor Systematic Name||Type||Assay||Annotation||Action||Modification||Phenotype||Source||Reference||Note|\n|Evidence ID||Analyze ID||Gene||Gene Systematic Name||Gene Ontology Term||Gene Ontology Term ID||Qualifier||Aspect||Method||Evidence||Source||Assigned On||Reference||Annotation Extension|\n|Evidence ID||Analyze ID||Gene||Gene Systematic Name||Phenotype||Experiment Type||Experiment Type Category||Mutant Information||Strain Background||Chemical||Details||Reference|\n|Evidence ID||Analyze ID||Regulator||Regulator Systematic Name||Target||Target Systematic Name||Experiment||Conditions||Strain||Source||Reference|", "domain": "chemistry", "round": 3} +{"url": "https://profiles.ouhsc.edu/display/832943", "date": "2023-01-30T17:35:58Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-06/segments/1674764499826.71/warc/CC-MAIN-20230130165437-20230130195437-00807.warc.gz", "language_score": 0.9080811738967896, "token_count": 307, "dump": "CC-MAIN-2023-06", "global_id": "webtext-fineweb__CC-MAIN-2023-06__0__105787680", "lang": "en", "text": "IRON UTILIZATION BY NEISSERIA MENINGITIDIS\nThe objective of the proposed research is to understand the mechanisms of iron acquisition by Neisseria meningitidis. We will be examining the role of iron-repressible outer membrane proteins in this process, using both classical and molecular genetic approaches. We will attempt to resolve the existing controversy as to whether the meningococcus produces a hydroxamate siderophore, and will examine the possibility that a putative siderophore may be produced in response to environmental cues other than iron-limitation. Since transferrin and lactoferrin are available in vivo at sites where the meningococcus resides, we expect that the study of these two iron sources in vitro is biologically relevant. The biological relevance of hemin and hemoglobin utilization is unclear at present; all assays done to date have used these iron carriers in their free form, while in the body they probably exist bound to carrier proteins (hemopexin and haptoglobin). Thus, we intend to assess how these carrier proteins affect the utilization of hemin and hemoglobin. These studies are important in furthering our understanding of a novel iron uptake system. These studies will provide an important basis for future studies on the relationship of meningococcal iron acquisition and virulence. Ultimately, this knowledge may be of use in the development of novel meningococcal vaccines directed against the meningococcal iron uptake system.", "domain": "chemistry", "round": 3} +{"url": "http://www.conferencedequebec.org/2018/10/01/the-anti-proliferative-activities-of-most-twenty-five-targeted-kinase-inhibitor-medicines-that/", "date": "2024-04-23T23:26:43Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712296818835.29/warc/CC-MAIN-20240423223805-20240424013805-00086.warc.gz", "language_score": 0.9122450947761536, "token_count": 1150, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__86171093", "lang": "en", "text": "The anti-proliferative activities of most twenty-five targeted kinase inhibitor medicines that are in clinical use were measured in two large assay panels: (1) a panel of proliferation assays of forty-four human being cancer cell lines from diverse tumour tissue origins; and (2) a -panel greater than 300 kinase enzyme activity assays. inside a following generation of medicines. Our study displays the energy of merging biochemical and mobile profiling data in the evaluation of kinase inhibitor medication action. Intro Targeted therapies considerably increase the effectiveness of malignancy therapy. They provide great advantage to individuals because they improve success rates with significantly less unwanted effects than traditional cytotoxic therapies. Little molecule inhibitors of proteins kinases certainly are a primary exemplory case of the achievement of targeted therapy. There are (Nov. 2013) twenty-five kinase inhibitor medicines authorized for medical make use of, all except two for malignancy (Desk 1 and Physique 1). In 2012 proteins kinases had been the solitary most successful focus on class predicated on the amount of authorized new medicines from the U.S. Meals and Medication Administration (FDA) which trend continuing in 2013 . Nevertheless, provided the high attrition of medication applicants, the limited success benefits of 1st era therapies, the issue of medication resistance and the actual fact that targeted therapy is of great benefit to a part of malignancy patients, there’s a need for book and improved targeted kinase inhibitors. Open up in another window Physique 1 2D constructions from the kinase inhibitors profiled with this study.Each is kinase inhibitors which were approved for clinical make use of in Nov. 2013. Desk 1 Summary of promoted kinase inhibitors, their applications and biochemical features. VEGFRs,VEGFR22.5MET4RET11 (Desk S3). The ABL1 inhibitors imatinib and nilotinib cluster collectively because they selectively inhibit the cell lines A-204 and K-562 that are reliant on ABL1 for development (Number 2C). However, additional kinase medicines inhibit the development of multiple cell lines, such axitinib, ponatinib, bosutinib, sunitinib and crizotinib, which cluster collectively in heat map (Number 2C), the mTOR inhibitors temsirolimus and everolimus, as well as the MEK inhibitor trametinib (Number 2C). To help expand analyse the mobile selectivity of kinase inhibitors, we likened the strongest cellular IC50 of the compound, like a measure of particular mobile activity, with the common IC50 in the entire -panel, like a way of measuring general mobile toxicity. Vintage cytotoxic therapies and bortezomib display a 10-collapse difference between your typical IC50 in the cell -panel as well as the strongest IC50 (Number 2D). On the other hand, most kinase inhibitors demonstrated a 100-fold difference, and dasatinib a good a lot more than 1000-fold difference Endothelin-2, human manufacture (Number 2D), demonstrating that kinase inhibitors certainly achieve a better selectivity window compared to traditional chemotherapeutic agencies. Biochemical Profiling of Clinical Kinase Inhibitors To relate the anti-proliferative activity of kinase inhibitor medications towards the inhibition of particular kinase goals, all compounds had been profiled at an individual focus on a -panel greater than 300 biochemical kinase assays (Body 3A, Desk S6) . Additionally, for the main targets, IC50 beliefs were motivated (Desk 1). For vemurafenib, dabrafenib, trametinib, regorafenib and cabozantinib, this is actually the first huge kinome profile in the general public domain. An evaluation from the accepted RAF inhibitors vemurafenib and dabrafenib implies that dabrafenib is a lot stronger than vemurafenib on outrageous type BRAF and mutant BRAF(V600E). Dabrafenib also inhibits significantly even more kinases (Desk 1; Body 3A). The initial account of trametinib unveils that, because so many MEK inhibitors , it really is exquisitely selective (Body 3A). Regorafenib is certainly a structural analog Endothelin-2, human manufacture of sorafenib and displays an identical biochemical profile (Body 3A). Regorafenib continues to be classified as stronger . However, the info show that is true because of Endothelin-2, human manufacture its inhibition of VEGFR2, a focus on of angiogenic medications, however, not for PDGFR, a focus Endothelin-2, human manufacture on in gastro-intestinal stromal tumours, a sign that regorafenib Rabbit Polyclonal to OR2B2 is accepted aswell (Desk 1). Biochemical inhibition of Link2, another receptor involved with angiogenesis, was minimal, in keeping with a prior report (Desk S6) . Rather, regorafenib has significant extra inhibitory activity on many oncogenic kinases, like the Ephrin receptors and p70S6K, that may donate to its differential scientific profile . Cabozantinib continues to be characterized being a mixed VEGFR2, MET and RET inhibitor and is among the strongest VEGFR2 inhibitors (Desk 1). It really is accepted for make use of in medullary.", "domain": "chemistry", "round": 3} +{"url": "https://scholars.hkbu.edu.hk/en/publications/extremely-low-efficiency-roll-off-of-phosphorescent-organic-light", "date": "2023-12-01T04:24:36Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100264.9/warc/CC-MAIN-20231201021234-20231201051234-00644.warc.gz", "language_score": 0.8784210681915283, "token_count": 482, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__194787315", "lang": "en", "text": "Three novel host materials, IpCm-PhBzAc (1,3-(4-(12,12-dimethylbenzofuro[3,2-b]acridin-7(12H)-yl)phenyl)-6-isopropyl-4H-chromen-4-one), DpAn-BzAc (2,10-(4-(12,12-dimethylbenzofuro[3,2-b]acridin-7(12H)-yl)phenyl)-10-phenylanthracen-9(10H)-one) and DpTrz-BphBzAc (3,7-(4′-(4,6-diphenyl-1,3,5-triazin-2-yl)-[1,1′-biphenyl]-4-yl)-12,12-dimethyl-7,12-dihydrobenzofuro[3,2-b]acridine) have been designed and synthesized, and their utilization as host materials for phosphorescent organic light-emitting diodes (PhOLEDs) has been investigated. We have fabricated PhOLEDs using green bis(2-phenylpyridine)iridium(iii) acetylacetonate as doped emitters and two hosting schemes, which are the single host system consisting of BzAc derivatives and the co-host system with 1,3-bis(carbazolyl)benzene. We found that the PhOLEDs with the co-host system of DpAn-BzAc and DpTrz-BphBzAc achieved CEs of 57.1 cd A−1 and 53.0 cd A−1, with corresponding efficiency roll-off of only 7.6% and 0.9%, respectively, from the maximum to the practical brightness of 5000 cd m−2. Extremely reduced efficiency roll-off values for BzAc-based PhOLEDs were attributed to their superior thermal stability and excellent bipolar transport properties, and a small singlet-triplet energy gap also afforded efficient reverse intersystem crossing, thus reducing the triplet density of the host for PhOLEDs.\nScopus Subject Areas\n- Materials Chemistry", "domain": "chemistry", "round": 3} +{"url": "https://www.freethesaurus.com/Castanospermum", "date": "2020-09-26T22:01:51Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-40/segments/1600400245109.69/warc/CC-MAIN-20200926200523-20200926230523-00589.warc.gz", "language_score": 0.7020060420036316, "token_count": 340, "dump": "CC-MAIN-2020-40", "global_id": "webtext-fineweb__CC-MAIN-2020-40__0__237503824", "lang": "en", "text": "The present findings justify that Castanospermum australe canbe used as a natural source for alternative or supplementary therapeutic drug for the treatment of analgesic and inflammatory diseases.\nJewess et al., \"Castanospermine, A 1,6,7,8-tetrahydroxyoctahydroindolizine alkaloid, from seeds of Castanospermum australe,\" Phytochemistry, vol.\nDuke, \"Castanospermum and anti-aids activity,\" Journal of Ethnopharmacology, vol.\nHeble, \"Castanospermine, an HIV inhibitor from tissue cultures of Castanospermum australe,\" Phytotherapy Research, vol.\nChen et al., \"Antihyperglycemic effects of N-containing sugars from Xanthocercis zambesiaca, Morus bombycis, Aglaonema treubii, and Castanospermum australe in streptozotocin-diabetic mice,\" Journal of Natural Products, vol.\nAbbreviations: CAS, Castanospermum australe seed; PX-407, poloxamer-407; T2DM.\nTriterpenoidsaponins from leaves of Castanospermum australe.\nExtraction of Australian timers, IV Cas-tanogenin (Medicagenic acid) and Bayogenin, C30 1148 05 * from Castanospermum australe Cunnet Fras, Austral.\nA novel pyrolizidine alkaloid glucosidase inhibitor from Castanospermum austrate.", "domain": "chemistry", "round": 3} +{"url": "http://www.abcam.com/Nkx3-1-antibody-4H4-ab96482.html", "date": "2013-12-12T14:14:50Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2013-48/segments/1386164607702/warc/CC-MAIN-20131204134327-00088-ip-10-33-133-15.ec2.internal.warc.gz", "language_score": 0.7581160068511963, "token_count": 895, "dump": "CC-MAIN-2013-48", "global_id": "webtext-fineweb__CC-MAIN-2013-48__0__149622699", "lang": "en", "text": "Anti-Nkx3.1 antibody [4H4] (ab96482)\n- Product nameAnti-Nkx3.1 antibody [4H4]See all Nkx3.1 primary antibodies ...\n- DescriptionMouse monoclonal [4H4] to Nkx3.1\n- Tested applicationsWB, ELISA, IHC-P, Flow Cyt more details\n- Species reactivityReacts with: Human\nRecombinant fragment, corresponding to amino acids 1-234 of Human Nkx3.1\n- Positive control\n- LNCaP cell lysate. Human prostate tissue. PC-3 cells.\n- Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.\n- Storage bufferPreservative: 0.03% Sodium Azide\n- Concentration information loading...\n- Clonality Monoclonal\n- Clone number4H4\n- Research Areas\nOur Abpromise guarantee covers the use of ab96482 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\n|WB||WB: 1/500 - 1/2000. Predicted molecular weight: 26 kDa.|\n|IHC-P||IHC-P: 1/200 - 1/1000.|\n|Flow Cyt||Flow Cyt: 1/200 - 1/400.|\n- FunctionTranscription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Play an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Act as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells.\n- Tissue specificityHighly expressed in the prostate and, at a lower level, in the testis.\n- Sequence similaritiesBelongs to the NK-3 homeobox family.\nContains 1 homeobox DNA-binding domain.\nmodificationsUbiquitinated by TOPORS; monoubiquitinated at several residues and also polyubiquitinated on single residues.\n- Cellular localizationNucleus.\n- BAPX 2 antibody\n- BAPX2 antibody\n- Homeobox protein NK-3 homolog A antibody\n- Homeobox protein Nkx 3.1 antibody\n- Homeobox protein Nkx-3.1 antibody\n- Homeobox protein Nkx3.1 antibody\n- NK homeobox (Drosophila) family 3 A antibody\n- NK homeobox family 3 A antibody\n- NK homeobox, family 3, member A antibody\n- NK3 homeobox 1 antibody\n- NK3 transcription factor homolog A antibody\n- NK3 transcription factor related locus 1 antibody\n- NKX 3 antibody\n- Nkx 3.1 antibody\n- NKX 3A antibody\n- NKX3 1 antibody\n- NKX3 antibody\n- Nkx3-1 antibody\n- NKX3.1 antibody\n- Nkx3.1, mouse, homolog of antibody\n- NKX31_HUMAN antibody\n- NKX3A antibody\nAnti-Nkx3.1 antibody [4H4] images\nAnti-Nkx3.1 antibody [4H4] (ab96482) at 1/500 dilution + LNCaP cell lysate\nPredicted band size : 26 kDa\nImmunohistochemical analysis of paraffin-embedded Human prostate tissues (A, B) using ab96482 at 1/200 dilution with DAB staining.\nFlow cytometry analysis of PC-3 cells using ab96482 at 1/200 dilution (green) and negative control (purple).\nReferences for Anti-Nkx3.1 antibody [4H4] (ab96482)\nab96482 has not yet been referenced specifically in any publications.", "domain": "chemistry", "round": 3} +{"url": "https://isaiminis.com/the-fantastic-power-of-mod-grf-1-29-ghrp-6.html", "date": "2024-04-22T23:11:37Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712296818374.84/warc/CC-MAIN-20240422211055-20240423001055-00238.warc.gz", "language_score": 0.9425358772277832, "token_count": 815, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__131997448", "lang": "en", "text": "Peptide injections boost GH production by injecting Mod GRF 1-29 (commonly known as Mod GRF). One of the most often used GHRH mimics a peptide called ghrelin. A GHRH might be referred to as such since it performs similarly.\nMod GRF 1-29 is primarily used to raise GH levels and IGF-1 levels. Some studies have shown that increasing these levels may promote weight reduction and muscle building. If you’re looking for an alternative to GH injections, Mod GRF 1-29 is a great option.\nCJC-1295 is the primary GHRH product. Most of the time, researchers prefer Mod GRF 1-29 over CJC-1295. The products’ duration of action varies. Pulsatile dosing is possible with Mod GRF 1-29 because of its near-ideal fast action duration. However, this is not possible with CJC-1295 because of its longer action duration.\nWhen sold as “CJC-1295 with no DAC,” Mod GRF 1-29 is often called “CJC-1295.” This is a baffling name for a product, since Mod GRF is all you need to know about it. A peptide is not CJC-1295 if it lacks DAC.\nA peptide of the GHRP class, such as GHRP-2, GHRP-6, or Hexarelin, is usually used in conjunction with Mod GRF 1-29 to get the best results.\nThe use of the Mod GRF 1-29 and GHRP’s\nWhen used in conjunction with a GHRP product, Mod GRF 1-29 is most effective. When a GHRP is used with a Mod GRF, the quantity of additional GH generation necessitates a smaller GHRP. When employing the same quantity of a GHRP, the production of GH might be increased significantly.\nOne hundred mcg of Mod GRF 1-29 may be used in conjunction with 100 mcg of GHRP-6 or ipamorelin, for example. If you were to administer 300 mcg of each GHRP product on its own, you’d get at least as much GH release.\nThe synergy between Mod GRF 1-29 and a GHRP is evident. The GHRP causes a burst of GH production, and the Mod GRF enhances it.\nPharmacological class of Mod GRF 1-29\nNatural GHRH is also known as GHRH; it is not utilized in bodybuilding or as a performance-enhancing medication because of the high cost of manufacturing and the short duration of effect of the natural molecule. It’s a modified form of GHRH’s first 29 amino acids called Mod GRF, and it’s stable enough in the body to have a short-term effect.\nHowever, unlike GHRH, the injection of Mod GRF does not cause a burst of GH release. Only if the injection is administered before a pulse can a single Mod GRF infusion improve GH release. This would result in a stronger pulse. It’s possible that the Mod GRF would not have been able to magnify the pulse had it not been for the injection.\nReasons why a Mod GRF/GHRP stack is less effective.\nLow thyroid levels or high IGF-1 levels, such as those associated with high doses of human growth hormone (GH) (14 IU/week and higher), as well as high blood sugar at the time of injection, would limit the efficacy of a Mod GRF 1-29/GHRP stack. In this case, there is no black and white dividing line or a definite cut-off point. Buy Mod GRF 1-29 & GHRP-6 online if you are a researcher.", "domain": "chemistry", "round": 3} +{"url": "https://inflammregen.biomedcentral.com/articles/10.1186/s41232-019-0091-3", "date": "2023-10-04T06:21:00Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233511361.38/warc/CC-MAIN-20231004052258-20231004082258-00637.warc.gz", "language_score": 0.8400632739067078, "token_count": 374, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__195690818", "lang": "en", "text": "Correction to: Roles of nitric oxide and ethyl pyruvate after peripheral nerve injury\nInflammation and Regeneration volume 39, Article number: 1 (2019)\nCorrection to: Inflamm Regen (2017) 37:20\nAfter publication of the original article , it came to our attention that Professor Junyang Jung was omitted from the authorship. The correct authorship is Sandesh Panthi, Kripa Gautam, and Junyang Jung.\nIn addition, the following funding information should have been included as part of Declarations:\n“Sandesh Panthi was supported by Basic Science Research Program through the Korean National Research Foundation (NRF) funded by the Ministry of Science, ICT and Future Planning (Professor Junyang Jung, 2015R1A2A2A01002735).”\nPanthi S, et al. Roles of nitric oxide and ethyl pyruvate after peripheral nerve injury. Inflamm Regen. 2017;37:20. https://doi.org/10.1186/s41232-017-0051-8.\nAbout this article\nCite this article\nPanthi, S., Gautam, K. & Jung, J. Correction to: Roles of nitric oxide and ethyl pyruvate after peripheral nerve injury. Inflamm Regener 39, 1 (2019). https://doi.org/10.1186/s41232-019-0091-3", "domain": "chemistry", "round": 3} +{"url": "http://www.lavoisier.eu/books/other/adenylyl-cyclase-g-proteins-and-guanylyl-cyclase/abelson/description_3572158", "date": "2019-04-20T13:21:41Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-18/segments/1555578529813.23/warc/CC-MAIN-20190420120902-20190420142902-00444.warc.gz", "language_score": 0.7026373744010925, "token_count": 2046, "dump": "CC-MAIN-2019-18", "global_id": "webtext-fineweb__CC-MAIN-2019-18__0__53323754", "lang": "en", "text": "Adenylyl Cyclase, G Proteins, and Guanylyl Cyclase\nMethods in Enzymology Series, Vol. 195\nEditors-in-Chief: Abelson John N., Simon Melvin I.Language: Anglais\nSubject for Adenylyl Cyclase, G Proteins, and Guanylyl Cyclase:\nSubject to availability at the publisher.Add to cart the livre\n512 p. · 15.2x22.9 cm\n* Adenylyl cyclase: determination of activity\n* Preparation of materials useful in purification of components of hormonally responsive cyclase systems\n* Purification guanine nucleotide-dependent regulatory proteins\n* Purification and characterization of g proteins: labeling and quantitating of G proteins\n* Reconstitution guanylyl cyclase: assay\n* Preparation of materials used for study of the cyclase\nR.A. Johnson and Y. Salomon, Assay of Adenylyl Cyclase Catalytic Activity.\nY. Salomon, Cellular Responsiveness to Hormones and Neurotransmitters: Conversion of [3H]Adenine to [3H]cAMP in Cell Monolayers, Cell Suspensions, and Tissue Slices.\nPreparation of Materials Useful in Purification of Components of Hormonally Responsive Adenyl Cyclase Systems:\nT.F. Walseth, P.S.T. Yuen, and M.C. Moos, Jr. , Preparation of ~ga-32P-Labeled Nucleoside Triphosphates, Nicotinamide Adenine Dinucleotide, and Cyclic Nucleotides for Use in Determining Adenylyl and Guanylyl Cyclases and Cyclic Nucleotide Phosphodiesterases.\nT. Pfeuffer, Synthesis of Forskolin-Agarose Affinity Matrices.\nA. Laurenza and K.B. Seamon, High-Affinity Binding Sites for [3H]Forskolin.\nPurification of Adenylyl Cyclases:\nP. Wang and D.R. Storm, Purification and Characterization of Calmodulin-Sensitive Adenylyl Cyclase from Bovine Brain.\nE. Pfeuffer, S. Mollner, and T. Pfeuffer, Purification of Adenylyl Cyclase from Heart and Brain.\nW.A. Toscano, Jr., and M.K. Gross, Calmodulin-Mediated Adenylyl Cyclase from Equine Sperm.\nG.B. Rosenberg, P. Wang, and D.R. Storm, Isolation of Polyclonal Antibodies against Bovine Brain Calmodulin-Sensitive Adenylyl Cyclases.\nS. Mollner and T. Pfeuffer, Characteristics and Use of Monoclonal Antibodies to Various Forms of Adenylyl Cyclase.\nT. Braun, Purification of Soluble Form of Adenylyl Cyclase from Testes.\nH.R. Masure, M.G. Donovan, and D.R. Storm, Purification and Assay of Cell-Invasive Form of Calmodulin-Sensitive Adenylyl Cyclase from Bordetella pertussis.\nS.H. Leppla, Purification and Characterization of Adenylyl Cyclase from Bacillus anthracis.\nGuanine Nucleotide-Dependent Regulatory Proteins: Purification and Characterization of G Proteins:\nE. Pfeuffer and T. Pfeuffer, Preparation and Application of GTP-Agarose Matrices.\nJ. Codina, D.J. Carty, L. Birnbaumer, and R. Iyengar, Purification of G Proteins.\nK.M. Ferguson and T. Higashijima, Preparation of Guanine Nucleotide-Free G Proteins.\nM.P. Graziano, M. Freissmuth, and A.G. Gilman, Purification of Recombinant Gs~ga.\nM.E. Linder and A.G. Gilman, Purification of Recombinant Gi~ga and G~ Proteins from Escherichia coli.\nS.M. Mumby and A.G. Gilman, Synthetic Peptide Antisera with Determined Specificity for G Protein ~ga or ~gb Subunits.\nR.A. Kahn, Quantitation and Purification of ADP-Ribosylation Factor.\nJ. Moss, S.-C. Tsai, S.R. Price, D.A. Bobak, and M. Vaughan, Soluble Guanine Nucleotide-Dependent ADP-Ribosylation Factors in Activation of Adenylyl Cyclase by Choleragen.\nLabeling and Quantitating of G Proteins:\nG.S. Kopf and M.J. Woolkalis, ADP-Ribosylation of G Proteins with Pertussis Toxin.\nD.M. Gill and M.J. Woolkalis, Cholera Toxin-Catalyzed [32P]ADP-Ribosylation of Proteins.\nR.Thomas and T. Pfeuffer, Photoaffinity Labeling of GTP-Binding Proteins.\nS. Offermanns, G. Schultz, and W. Rosenthal, Identification of Receptor-Activated G Proteins Using Photoreactive GTP Analog, ~ -32P]GTP Azidoanilide.\nD.J. Carty, R.T. Premont, and R. Ivengar, Quantitative Immunoblotting of G-Protein Subunits.\nP.J. Casey, I.-H.Pang, and A.G. Gilman, Assay of G-Protein ~gb~gg-Subunit Complex by Catalytic Support of ADP-Ribosylation of Go~ga.\nT. Higashijima and K.M. Ferguson, Tryptophan Fluorescence of G Proteins: Analysis of Guanine Nucleotide Binding and Hydrolysis.\nR.A. Cerione and E.M. Ross, Reconstitution of Receptors and G Proteins in Phospholipid Vesicles.\nGuanylyl Cyclase: Assay of Guanylyl Cyclase:\nS.E. Domino, D.J. Tubb, and D.L. Garbers, Assay of Guanylyl Cyclase Catalytic Activity.\nPurifcation and Characterization of Guanylyl Cyclase Isozymes:\nA. M~adulsch and R. Gerzer, Preparative Polyacrylamide Gel Electrophoresis Apparatus for Purification of Guanylyl Cyclase.\nA.A. White and P.J. Lad, Detergent Interactions and Solubilization Techniques for Membrane Guanylyl Cyclase.\nC.S. Ramarao and D.L. Garbers, Purification of Membrane Form of Guanylyl Cyclase.\nA. M~adulsch and R. Gerzer, Purification of Heme-Containing Soluble Guanylyl Cyclase.\nP. Humbert, F. Niroomand, G. Fischer, B. Mayer, D. Koesling, K.-D. Hinsch, G. Schultz, and E. B~adohme, Preparation of Soluble Guanylyl Cyclase from Bovine Lung by Immunoaffinity Chromatography.\nS.A. Waldman, D.C. Leitman, and F. Murad, Immunoaffinity Purification of Soluble Guanylyl Cyclase.\nS.A. Waldman, D.C. Leitman, and F. Murad, Copurification of Atrial Natriuretic Peptide Receptor and Particulate Guanylyl Cyclase.\nT. Inagami, R. Takayanagi, and R.M. Snajdar, Copurification of Atrial Natriuretic Factor Receptors and Guanylyl Cyclase from adrenal Cortex.\nS. Singh and D.L. Garbers, Molecular Cloning of Membrane Forms of Guanylyl Cyclase.\nM. Potier, C. Huot, C. Koch, P. Hamet, and J.Tremblay, Radiation-Inactivation Analysis of Multidomain Proteins: The Case of Particulate Guanylyl Cyclase.\nRegulation of Guanylyl Cyclases:\nD.C. Leitman, S.A. Waldman, and F. Murad, Identification of Atrial Natriuretic Peptide Receptors in Cultured Cells.\nP. Hamet and J. Tremblay, Evaluating Atrial Natriuretic-Induced cGMP Production by Particulate Guanylyl Cyclase Stimulation in Vitro and in Vivo.\nJ.K. Bentley, Phosphorylation and Dephosphorylation of Sea Urchin Sperm Cell Guanylyl Cyclase.\nJ.E. Schultz and S. Klumpp, Calcium-Regulated Guanylyl Cyclases from Paramecium and Tetrahymena.", "domain": "chemistry", "round": 3} +{"url": "https://www.tech-strategy.org/2016/04/implemented-an-unbiased-cell-morphology-based-display-screen-to-recognize-small-molecule-modulators/", "date": "2023-11-30T17:54:31Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100229.44/warc/CC-MAIN-20231130161920-20231130191920-00209.warc.gz", "language_score": 0.871188759803772, "token_count": 905, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__254540421", "lang": "en", "text": "implemented an unbiased cell morphology-based display screen to recognize small-molecule modulators of cellular procedures utilizing the Cytometrix (TM) automated imaging and Clec1a evaluation program. We resolved the X-ray crystal framework from the CBR1/hydroxy-PP complicated to at least one 1.24 ? quality. Structure-based style of stronger and selective CBR1 inhibitors supplied probes for examining the natural function of CBR1 in A549 cells. These research revealed a unidentified function for CBR1 in serum-withdrawal-induced apoptosis previously. Additional research indicate CBR1 inhibitors might improve the effectiveness of anticancer anthracyclines. Morphology-based testing of diverse cancer tumor cell types provides provided a way for discovering powerful brand-new small-molecule probes for cell natural research and anticancer medication candidates. Launch Many current medications had been originally uncovered through observation of unforeseen natural actions (e.g. penicillin benzodiazepines sildenafil MLN2238 [Viagra]). Comprehensive screens for natural function have the benefit of identifying the very best “lock” for every new “essential” made by chemical substance variation. On the other hand the seek out drug-like strikes by high-throughput strategies is normally dominated by in vitro single-enzyme activity-based displays and single-readout cell-based assays. These strategies measure not a lot of regions of natural space nor reveal potent results on pathways not really being measured straight. To be able to systematize the knowledge of the entire activity of brand-new small substances we quantified dose-dependent morphological adjustments induced in five cell types thus identifying “strike” substances with unique actions. The assay is dependant on the principle that MLN2238 lots of cellular targets get excited about the control of mobile morphology DNA content material MLN2238 and area and morphology from the Golgi equipment ([1 2 3 C. L. Adams D. A. Coleman G. Cong A. M. Crompton K. A. Elias et al. unpublished data). Cell-type-specific elements are recognized to make use of distinctive pathways and mobile programs to regulate fundamental processes impacting the top features of the organelles and the entire mobile morphology. Five cell types (lung adenocarcinoma ovarian cancers a neuronal glioma a prostate cancers and endothelial cells) had been contained in the morphological display screen. The approach continues to be validated by evaluation of known pharmacologically energetic substances from ten different system of MLN2238 actions classes (actin inhibitors calmodulin antagonists endoplasmic reticulum Ca2+ ATPase inhibitors geranylgeranyl transferase-1 inhibitors MLN2238 G-protein-coupled receptor activators proteins kinase C activators topoisomerase II inhibitors tubulin destabilizers tubulin stabilizers and kinase inhibitors). Atlanta divorce attorneys case a higher percentage from the substances had been accurately classified in to the ten different system of action groupings utilizing the Cytometrix (TM) program (C. L. Adams D. A. Coleman G. Cong A. M. Crompton K. A. Elias et al. unpublished data). A display screen of 107 little molecules composed of four different chemical substance scaffolds recognized to inhibit proteins kinases with differing selectivity and strength had been chosen for the Cytometrix display screen. In this survey we concentrate on a hydroxyl-substituted analog 3 attempted crystallization from the proteins in the current presence of hydroxy-PP in order to enhance style of a selective CBR1 inhibitor. Within 2 d at area temperature great diffracting crystals from the orthorhombic space group P212121 had been attained by vapor diffusion from 100 mM sodium-2-(N-ethylmorpholino)ethanesulfonate (pH 6.5) 2 M ammonium sulfate and 5% PEG 400. Orthorhombic crystals of CBR1-hydroxy-PP diffracted to at least one 1.1 ?. The framework was resolved by molecular substitute using the AMoRe plan utilizing a improved porcine carbonyl reductase model and enhanced with SHELXL to at least one 1.24 ? using a crystallographic R-factor of 10.3% and a free of charge..", "domain": "chemistry", "round": 3} +{"url": "https://gentaur.com/prod/anti-human-cd1a/mbs-monoclonals/1263416471?product=1012597687", "date": "2018-08-20T02:35:40Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-34/segments/1534221215523.56/warc/CC-MAIN-20180820023141-20180820043141-00306.warc.gz", "language_score": 0.7509520053863525, "token_count": 1451, "dump": "CC-MAIN-2018-34", "global_id": "webtext-fineweb__CC-MAIN-2018-34__0__66700977", "lang": "en", "text": "anti human CD1a\nanti human CD1a is available 5 times from Mbs monoclonals labs\nGEN666757 | anti-human CD1a-Biotinsize: 100ug | 447.67 USD\n- Catalog numberGEN666757\n- Price447.67 USD\n- Purification methodN/A\n- Form/Appearance50 mM Sodium Phosphate pH 7.5, 100 mM Potassium Chloride, 150mM NaCl, 5% Glycerol, 0.2% BSA.\n- Concentration1.0 mg/ml\n- Storage and shippingStore the antibody at +4°C. Freezing/thawing cycles should be avoided in order to retain the full activity. Do not expose the vials to direct bright light. If stored under proper conditions, the antibody will retain its activity for at least one year.\n- DescriptionThis antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.\n- TestMBS Monoclonals supplies antibodies that are for research of human proteins.\n- PropertiesBiotin conjugates can be detected by horseradish peroxidase, alkaline phosphatase substrates or anti biotin conjugated antibodies. Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA. To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1.6.Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.\n- Gene target\n- Short nameanti- CD1a-\n- Techniqueanti-Human, anti\n- Alternative nameantibody to-H. sapiens CD1a molecule-biotinilated\n1. Gene info\n- Long gene nameCD1a molecule\n- Synonyms gene\n- Synonyms gene name\n- CD1A antigen, a polypeptide\n- CD1a antigen\n- GenBank acession\n- Discovery year1988-05-11\n- Entrez gene record\n- Pubmed identfication\n- RefSeq identity\n- C1-set domain containing\n- CD molecules\n- Havana BLAST/BLAT\n- ConceptScope note:Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.\n- Tree numbers\n- PubMedThese findings identify Ii and lipid rafts as key regulators of CD1a organization on the surface of immature DCs and of its immunological function as Ag-presenting moleculeMolecular mechanisms by which CD1c captures distinct classes of self- and mycobacterial antigens are reviewed. Review.The positive and significant correlations between the number of CD1a+ cells and positivity of the primary tumour for estrogen receptor and progesterone receptor suggest a possible role for CD1a as a prognostic marker for breast cancer.The intracellular trafficking route of CD1a is essential for efficient presentation of lipid antigens that traffic through the early endocytic and recycling pathways.High CD1a-positive dendritic cell density is associated with improved disease-free survival in papillary thyroid carcinoma.\n- Gene ontology - Biological process\n- Gene ontology - Cellular component\n- Gene ontology - Molecular function\n- Entrez Gene\nGEN666201 | anti-human CD1a-FITCsize: 120 Tests | 447.67 USD\nGEN666715 | anti-human CD1a-Pur WAsize: 100ug | 396.41 USD\nGEN666067 | anti-human CD1a-Pur/PFsize: 100ug | 396.41 USD\nGEN666055 | anti-human CD1a-R-PEsize: 120 Tests | 567.27 USD\n- Also known asCD1a\n- Other namesCD1a antigen; T-cell surface glycoprotein CD1a; T-cell surface glycoprotein CD1a; hTa1 thymocyte antigen; CD1A antigen, a polypeptide; cluster of differentiation 1 A; T-cell surface antigen T6/Leu-6; cortical thymocyte antigen CD1A; differentiation antigen CD1-alpha-3; epidermal dendritic cell marker CD1a; CD1a molecule; T-cell surface antigen T6/Leu-6; hTa1 thymocyte antigen; CD_antigen: CD1a\n- SubcategoryMnoclonal antibodies\n- Gene nameCD1a\n- Gene name synonimsN/A\n- Other gene namesCD1A; CD1A; R4; T6; CD1; FCB6; HTA1; hTa1 thymocyte antigen\n- Immunoglobulin isotypeIgG1k\n- Host organismMouse (Mus musculus)\n- Species reactivityHuman (Homo sapiens); Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby.\n- Specificity and cross-reactivityN/A; Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited. This particular antibody might cross react with speacies outside of the listed ones.\n- Tested applications:Flow Cytometry (FC/FACS)\n- Alternative techniqueantibodies\n- Alternative to gene targetCD1a molecule, CD1 and FCB6 and HTA1 and R4 and T6, CD1A and IDBG-103736 and ENSG00000158477 and 909, protein binding, Plasma membranes\nRecombinant Neisseria gonorrhoeae Type IV pilus biogenesis and competence protein PilQ (pilQ), partial", "domain": "chemistry", "round": 3} +{"url": "https://www.eurekaselect.com/article/33950", "date": "2023-03-22T06:13:12Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-14/segments/1679296943750.71/warc/CC-MAIN-20230322051607-20230322081607-00123.warc.gz", "language_score": 0.9066718816757202, "token_count": 311, "dump": "CC-MAIN-2023-14", "global_id": "webtext-fineweb__CC-MAIN-2023-14__0__143283819", "lang": "en", "text": "The serine/threonine kinase Akt, also known as protein kinase B (PKB), plays a key role in cell survival and proliferation through a number of downstream effectors. Recent studies indicate that unregulated activation of the Phosphatidylinositol 3-kinase (PI3K)/Akt pathway is a prominent feature of many human cancers and Akt is overexpressed or activated in all major cancers. For these reasons, Akt is considered as an attractive target for cancer therapy. In the past few years, several series of compounds with diverse structural features have been reported as Akt inhibitors, such as, ATP-competitive inhibitors, Phosphatidylinositol (PI) analogs, and allosteric inhibitors. Although most of the inhibitors exhibited potent inhibitory activities at nanomolar concentrations against Akt, some of them have shown unfavorable selectivity against other protein kinases especially PKA and PKC. This review will focus on the recent advances in the development and biological evaluation of selective ATP-competitive inhibitors for Akt. We will summarize the novel approaches toward the developments of selective ATP-competitive inhibitors, expecting to give information to design new ATP-competitive inhibitors with high selectivity, bioavailability, and potency.\nKeywords: Akt, ATP-competitive inhibitors, PI3K/Akt signaling pathway, selective, Serine, Threonine, Phosphatidylinositol, allosteric inhibitors, downstream effectors, protein kinase B", "domain": "chemistry", "round": 3} +{"url": "https://www.gowinglife.com/longevity-briefs-nmn-supplements-reduce-blood-pressure-in-hypertensives/", "date": "2023-12-06T12:10:48Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100593.71/warc/CC-MAIN-20231206095331-20231206125331-00753.warc.gz", "language_score": 0.9625633955001831, "token_count": 849, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__14967802", "lang": "en", "text": "Posted on 6 October 2023\nLongevity briefs provides a short summary of novel research in biology, medicine, or biotechnology that caught the attention of our researchers in Oxford, due to its potential to improve our health, wellbeing, and longevity.\nWhy is this research important: Blood pressure inevitably increases with increasing age, which in turn increases the risk of cardiovascular diseases, dementia and more. One of the factors that contributes to hypertension is the decline in levels of a molecule called NAD+ during ageing. NAD+ (nicotinamide adenine dinucleotide) is essential for the production of ATP, the cell’s universal fuel source, and also many other processes such as the repair of damaged DNA. NAD+ protects the lining of blood vessels from inflammation and is involved in the production of nitric oxide (which dilates blood vessels), thereby protecting against high blood pressure.\nNAD+ levels can be increased by taking supplements such as NMN (nicotinamide mononucleotide), a precursor molecule that cells can use to synthesise NAD+. NMN is marketed as an anti-ageing supplement, though many are sceptical of this claim due to the sparsity of human clinical trial data. Mouse experiments have shown that boosting NAD+ levels with NMN can improve vascular health and protect against hypertension. They’ve also shown that CD38, an enzyme produced by immune cells that breaks down NAD+, plays an important role in cardiovascular health. When this CD38 enzyme is inhibited in mice, NAD+ levels are restored and the cardiovascular system is protected from damage. However, it’s not clear whether this relationship between CD38 and NAD+ exists in humans with hypertension.\nWhat did the researchers do: In this study, researchers recruited 102 people, about half of whom had been recently diagnosed with hypertension. They began by measuring NAD+ levels and CD38 expression in the blood vessels of participants and looked at whether these measurements were correlated with blood pressure. They also cultured cells from human aortas and either boosted or blocked their production of CD38 to see what effect this would have.\nThey then conducted a clinical trial in which 19 participants with hypertension were treated with lifestyle modifications, and 10 of those participants were randomly selected to receive NMN. This trial lasted 6 weeks, with the goal being to see whether taking NMN could boost NAD+ levels and thereby reduce blood pressure relative to those who only received lifestyle modifications.\nKey takeaway(s) from this research: In the initial measurements, researchers found that hypertensive patients had far lower NAD+ levels in their blood vessels than the non-hypertensive participants on average, while the opposite was true of CD38. The cell culture experiments provided evidence that NAD+ and CD38 levels were linked: inhibiting CD38 production in human aorta cells resulted in an increase in NAD+ levels and vice-versa. Inhibiting CD38 also improved the ability of the aortic cells to repair themselves.\nBut what about the most important part: the human trial? Systolic blood pressure in the group receiving NMN was reduced by 7 mm Hg, compared to a 2.5 mm Hg reduction in the group who only received lifestyle interventions. This was a statistically significant difference, but there was no significant difference when it came to diastolic blood pressure.\nSo, while this study is quite small, it suggests that supplements that can increase NAD+ levels, such as NMN and NR (nicotinamide riboside), may be effective in lowering blood pressure in hypertensive people. Both of these supplements are safe with few side effects. It also suggests that CD38 plays an important role in lowering NAD+ levels in the blood vessels of hypertensives, providing another potential therapeutic target. Unfortunately, there’s currently no drug to safely lower CD38 levels in humans, so it will be some time before we know whether this strategy can be effective.\nNAD+ exhaustion by CD38 upregulation contributes to blood pressure elevation and vascular damage in hypertension https://doi.org/10.1038/s41392-023-01577-3\nTitle image by Mockup Graphics, Upslash", "domain": "chemistry", "round": 3} +{"url": "https://research.monash.edu/en/publications/binding-of-purified-14-3-3-%CE%B6-signaling-protein-to-discrete-amino-", "date": "2022-12-07T14:41:53Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-49/segments/1669446711162.52/warc/CC-MAIN-20221207121241-20221207151241-00568.warc.gz", "language_score": 0.8595767617225647, "token_count": 741, "dump": "CC-MAIN-2022-49", "global_id": "webtext-fineweb__CC-MAIN-2022-49__0__125777016", "lang": "en", "text": "The glycoprotein (GP) Ib-IX-V complex constitutively expressed on the platelet plasma membrane mediates initial adhesion of circulating platelets to vessel wall matrix at high shear, and shear-induced platelet aggregation. In both cases, this involves binding of GP Ib-IX-V to the adhesive glycoprotein, von Willebrand Factor (vWF). vWF binding to GP Ib-IX-V rapidly induces platelet activation, leading to cytoskeletal rearrangement, shape change, and secretion that enables αIIbβ3 integrin (GP Ilb-IIIa)-dependent platelet aggregation. All these events are critical in (patho)physiological thrombus formation. The recent discovery that the signaling protein, 14-3-3 ζ, copurifies with the GP Ib-IX complex (minus GP V) [Du, X., Harris, S. J., Tetaz, T. J., Ginsberg, M. H., and Berndt, M. C. (1994) J. Biol. Chem. 269, 18287-18290] indicated a potential mechanism for vWF-dependent signaling. The aim of the present study was to identify discrete amino acid sequences that bind 14-3-3 ζ within the cytoplasmic domain of the receptor. As an initial screening assay, overlapping synthetic peptides based on the cytoplasmic domains of GP Ibα (100 residues), GP Ibβ (34 residues), GP IX (5 residues), and GP V (16 residues) were immobilized and assessed for the ability to bind purified 14-3-3 ζ. The C-terminal sequence GHSL of GP Ibα was identified as one 14-3-3 ζ interactive sequence, consistent with previous results [Du, X., Fox, J. E., and Pei, S. (1996) J. Biol. Chem. 271, 7362-7367]. Binding of 125I-labeled 14-3-3 ζ to GHSL-containing peptides was inhibitable by unlabeled 14-3-3 ζ and by anti-14-3-3 ζ IgG. Ala-walking through the GHSL sequence suggested all residues were necessary for optimal binding. In addition, 14-3-3 bound with lower affinity to a peptide based on the central region of the GP Ibα cytoplasmic domain (Arg-557-Gly-575), whereas peptide sequences within the cytoplasmic domains of GP Ibβ (Arg-160-Arg-175) and GP V (Lys-529-Gly-544) bound 14-3-3 ζ with comparable affinity to the GHSL- containing peptide. Soluble GHSL-containing peptides, GP Ibβ- and GP V- based peptides semidissociated 14-3-3 from GP Ib-IX-V or GP Ib-IX in platelet extracts as analyzed by immunoprecipitation, suggesting these sequences, at least partially, mediate the GP lb-IX-V- 14-3-3 ζ interaction in cells. Further, phosphorylation of the GP lbβ peptide at a site corresponding to a protein kinase A phosphorylation site (Ser-166) enhanced the affinity of 14- 3-3 ζ binding by approximately 8-fold, suggesting phosphorylation as a potential mechanism for regulating 14-3-3 ζ association with the GP Ib-IX-V complex.", "domain": "chemistry", "round": 3} +{"url": "https://link.springer.com/article/10.1023%2FA%3A1004500229385", "date": "2018-06-23T16:57:58Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-26/segments/1529267865098.25/warc/CC-MAIN-20180623152108-20180623172108-00470.warc.gz", "language_score": 0.6581065654754639, "token_count": 686, "dump": "CC-MAIN-2018-26", "global_id": "webtext-fineweb__CC-MAIN-2018-26__0__130957808", "lang": "en", "text": "Improvement in the optoelectronic properties of a-SiO:H films\n- 190 Downloads\nHydrogenated amorphous silicon oxide (a-SiO:H) films prepared by rf plasma enhanced chemical vapour deposition (PECVD) method have recently proved their potential as a photovoltaic material for the fabrication of high efficiency multijunction amorphous silicon solar cells. If deposited under proper conditions, it may be a better wide band gap material than the normally used a-SiC : H. In this paper we report the improvements achieved over the previously reported results. The films have been characterized in detail in terms of their optoelectronic properties, structural characteristics, defect density and light induced degradation.\nKeywordsPolymer Solar Cell Structural Characteristic Chemical Vapour Deposition Vapour Deposition\nUnable to display preview. Download preview PDF.\n- 1.K. Haga, A. Murakami, K. Yamamoto, M. Kumanoand H. Watanabe, Jpn. J. Appl. Phys. 30(1991) 3331.Google Scholar\n- 2.Y. Ichikawa, S. Fujikake, H. Ohta, T. Sasakiand H. Sakai, Proc. 22-nd IEEE Photovoltaic Conf. (LasVegas, 1991) p. 1296.Google Scholar\n- 3.A. Morimoto, H. Noriyamaand T. Shimizu, Jpn. J. Appl. Phys. 26(1987) 22.Google Scholar\n- 4.G. Suchaneck, O. Steinke, B. Alhallaniand K. Schade, J. Non-Cryst. Solids 187(1995) 86.Google Scholar\n- 5.P. Sichanugrist, T. Yoshida, Y. Ichikawaand H. Sakai J.Non-Cryst.Solids, 164–166 (1993) 1081.Google Scholar\n- 6.H. Watanabe, K. Hagaand T. Lohner, J. Non-Cryst. Solids 164–166 (1993) 1085.Google Scholar\n- 7.S. Fujikake, H. Ohta, P. Sichanugrist, M. Ohsawa, Y. Ichikawaand H. Sakai, Optoelectronics— Devices and Technologies 9(1994) 379.Google Scholar\n- 8.Debajyoti Das, S. M. Iftiquar, and A. K. Barua, J. Non-Cryst. Solids 210(1997) 148.Google Scholar\n- 9.G. Lucovsky, J. Yang, S. S. Chao, J. E. Tylerand W. Czubatyj Phys. Rev. B 28(1983) 3225.Google Scholar\n- 10.L. He, T. Inokuma, Y. Kurata, and S. Hasegawa, J. Non-Cryst. Solids 185(1995) 249.Google Scholar\n- 11.S. H. Baker, W. E. Spear, and R. A. G. Gibson, Phil. Mag. B 62(1990) 213.Google Scholar", "domain": "chemistry", "round": 3} +{"url": "https://scicrunch.org/17456562/resource/nif-0000-11872", "date": "2017-03-26T05:31:34Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-13/segments/1490218189127.26/warc/CC-MAIN-20170322212949-00331-ip-10-233-31-227.ec2.internal.warc.gz", "language_score": 0.865129292011261, "token_count": 364, "dump": "CC-MAIN-2017-13", "global_id": "webtext-fineweb__CC-MAIN-2017-13__0__258294905", "lang": "en", "text": "RNA-based affinity purification reveals 7SK RNPs with distinct composition and regulation.\nRecent studies have uncovered an unanticipated diversity of noncoding RNAs (ncRNAs), although these studies provide limited insight into their biological significance. Numerous general methods for identification and characterization of protein interactions have been developed, but similar approaches for characterizing cellular ncRNA interactions are lacking. Here we describe RNA Affinity in Tandem (RAT), an original, entirely RNA tag-based method for affinity purification of endogenously assembled RNP complexes. We demonstrate the general utility of RAT by isolating RNPs assembled in vivo on ncRNAs transcribed by RNA polymerase II or III. Using RAT in conjunction with protein identification by mass spectrometry and protein-RNA interaction assays, we define and characterize previously unanticipated protein subunits of endogenously assembled human 7SK RNPs. We show that 7SK RNA resides in a mixed population of RNPs with different protein compositions and responses to cellular stress. Depletion of a newly identified 7SK RNP component, hnRNP K, alters the partitioning of 7SK RNA among distinct RNPs. Our results establish the utility of a generalizable RNA-based RNP affinity purification method and provide insight into 7SK RNP dynamics.\nPubmed ID: 17456562 RIS Download\nBase Sequence | Escherichia coli | Heterogeneous-Nuclear Ribonucleoprotein K | Humans | Immunoblotting | Macromolecular Substances | Molecular Sequence Data | Nucleic Acid Conformation | RNA, Small Interfering | RNA, Small Nucleolar | RNA, Untranslated | Recombinant Proteins | Ribonucleoproteins | Transfection", "domain": "chemistry", "round": 3} +{"url": "https://www.armytekstore.de/chargers-and-baterries/baterries/", "date": "2024-03-01T07:25:00Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707947475203.41/warc/CC-MAIN-20240301062009-20240301092009-00155.warc.gz", "language_score": 0.854651689529419, "token_count": 273, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__129255677", "lang": "en", "text": "Branches of Armytek\nMon-Fr 9.00 - 18.00\nIn high demand – only 3 products left!\n18650 Li-Ion batteries are generally used in professional high-grade flashlights as they offer maximal capacity for most energy-consuming products.\n18650 Li-Ion unprotected batterie are high-quality batteries with an output voltage of 3.7V and a high capacity will ensure continued and efficient operation of your LED flashlight.\nIn high demand – only 5 products left!\nEconomic and environmentally friendly 18350 Li-Ion battery. It can be recharged over 500 times, which is equal to 500 CR123 batteries.\nArmytek CR123A batteries are ideal for LED flashlights, photo equipment, cameras, optics and other high current digital devices\n18650 Li-Ion 3500 mAh batteries provide maximal capacity and runtime for high amperage devices. Compatible with most Armytek flashlights.\nIn high demand – only 2 products left!\n21700 Li-Ion 5000 mAh rechargeable batteries are used in electric devices that require a high-capacity power source. They increase the productivity and runtime of the product. The batteries are compatible with Armytek flashlights of Pro Max version.\nNo items found matching the search criteria\n2024 Armytek GmbH.", "domain": "chemistry", "round": 3} +{"url": "https://pubmed.ncbi.nlm.nih.gov/21777186/?dopt=Abstract", "date": "2022-12-01T00:18:44Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-49/segments/1669446710777.20/warc/CC-MAIN-20221130225142-20221201015142-00597.warc.gz", "language_score": 0.8958749771118164, "token_count": 429, "dump": "CC-MAIN-2022-49", "global_id": "webtext-fineweb__CC-MAIN-2022-49__0__66558074", "lang": "en", "text": "The parathyroid hormone 1 receptor (PTH1R) is activated by parathyroid hormone (PTH) and parathyroid hormone related protein (PTHrP), hormones that mediate mineral ion homeostasis and tissue development, respectively. These diverse actions mediated by one receptor are likely due to the formation of cell-specific receptorsome complexes with cytosolic constituents. Through the second and third intracellular loops, the PTH1R couples to several G protein subclasses, including Gs, Gq/11, Gi/o and G12/13, resulting in the activation of many pathways. The PTH1R carboxy-terminal tail directs interactions with a plethora of binding partners. The WD1 and WD7 repeats of the G protein β subunit directly bind to a novel interaction domain located near the amino-terminal end of the PTH1R carboxy-terminal tail. This Gβγ binding site likely contributes to the promiscuous G protein coupling displayed by the PTH1R. Partially overlapping this site is an EF-hand binding domain that directs interactions with calpain, a calcium-activated protease, and calmodulin, a ubiquitous calcium sensor. A lysine-arginine-lysine motif located on the juxtamembrane region of the carboxy-terminal tail mediates interactions with ezrin, an actin-membrane cross-linking protein. The C-terminus of the PTH1R binds to the sodium-hydrogen regulatory factors (NHERFs) via a PDZ domain-mediated interaction, an association that influences signaling and membrane anchoring. Through direct interactions with ezrin and NHERF-1, a PTH1R receptorsome complex exists on apical membranes of the proximal tubule, an assembly that directs PTH-mediated regulation of phosphate transport. Targeting the PTH1R receptorsome will likely enhance therapies directed towards the treatment of osteoporosis and enhancing the hematopoietic stem cell niche.", "domain": "chemistry", "round": 3} +{"url": "https://shop.bowlertransmissions.com/collections/fluids-and-oil", "date": "2023-09-30T09:52:18Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233510671.0/warc/CC-MAIN-20230930082033-20230930112033-00846.warc.gz", "language_score": 0.8107258081436157, "token_count": 588, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__288262565", "lang": "en", "text": "Royal Purple Synchromax High Performance Manual Transmission Fluid (quart)\nSynchromax is recommended for manual transmissions that specify an automatic transmission fluid or motor oil. It is also ideal for transfer cases and 2-cycle motorcycle gear boxes.\nSynchromax is formulated with Royal Purple's synthetic, proprietary Synerlec additive technology, which offers improved shift quality over a wide temperature range and reduced gear noise.\nSynchromax is fully compatible with all types of friction materials and offers excellent corrosion and oxidation protection without affecting the soft metals commonly found in manual transmission synchronizers.\nStandard Packaging: 1 Quart Bottle\nGreater Wear Protection\nExcellent Rust/Corrosion Protection\nReduces Friction for More Power\nLowers Operating Temperatures\nRoyal Purple - Max ATF - Synthetic Automatic Transmission Fluid (quart)\nMax ATF is a synthetic, high-performance, automatic transmission fluid. Its low co-efficient of friction and high film strength help dramatically reduce heat and wear. Additionally, our premium ATF fluid gives you longer fluid life because it’s more oxidation-stable than other transmission fluids. A longer lasting synthetic transmission fluid can result in a number of advantages. Most often, Royal Purple customers report crisper shifting, improved fuel economy and increased power with Max ATF.\nMax ATF is scientifically engineered to extend the life of your transmission by reducing the amount of heat and wear on your transmission system. Automatic transmissions generate a great deal of heat and depend upon the transmission fluid for cooling and protection. More than 90 percent of all automatic transmission failures are caused by overheating; a 20°F reduction in fluid temperature can double the life of the transmission (Source: Perma Industries, Inc.).\nMax ATF is fully compatible and can be mixed with other automatic transmission fluids; however, for the best results, drain or flush the current oil and then fill with Max ATF synthetic automatic transmission fluid.\nMax ATF is NOT recommended for the following applications: Allison TES-389, DEXRON® VI, Ford Type F and MERCON® SP & LV, Honda DW-1, Hyundai SP-IV and NWS-9638, Kia SP-IV, JWS 3324, MAN 339 Z3, Mercedes Benz 236.8, 236.12, 236.14 & 236.15, Mitsubishi SP-IV and ATF J2, Nissan Matic-S, Saab 93-165-147, Shell M-1375.4 (ZF 6-Speed AT), Toyota WS (JWS 3324) and ZF TE-ML 14C. Max ATF is not recommended for use in any CVT or DCT applications.", "domain": "chemistry", "round": 3} +{"url": "https://pubmed.ncbi.nlm.nih.gov/11007774/", "date": "2021-11-27T15:28:52Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-49/segments/1637964358189.36/warc/CC-MAIN-20211127133237-20211127163237-00622.warc.gz", "language_score": 0.9332613348960876, "token_count": 373, "dump": "CC-MAIN-2021-49", "global_id": "webtext-fineweb__CC-MAIN-2021-49__0__203873102", "lang": "en", "text": "c-Src tyrosine kinase activity is elevated in several types of human cancer, and this has been attributed to elevated c-Src expression levels, increased c-Src specific activity, and activating mutations in c-Src. We have found a number of human breast cancer cell lines with elevated c-Src specific activity that also possess elevated phosphatase activity directed against the carboxyl-terminal negative regulatory domain of Src family kinases. To identify this phosphatase, cell extracts from MDA-MB-435S cells were chromatographed and the fractions were assayed for phosphatase activity. Four peaks of phosphatase activity directed against the nonspecific substrate poly(Glu/Tyr) were detected. One peak also dephosphorylated a peptide modeled against the c-Src carboxyl-terminal negative regulatory domain and intact human c-Src. Immunoblotting and immunodepletion experiments identified the phosphatase as protein-tyrosine phosphatase 1B (PTP1B). Examination of several human breast cancer cell lines with increased c-Src activity showed elevated levels of PTP1B protein relative to normal control breast cells. In vitro c-Src reactivation experiments confirmed the ability of PTP1B to dephosphorylate and activate c-Src. In vivo overexpression of PTP1B in 293 cells caused a 2-fold increase of endogenous c-Src kinase activity. Our findings indicate that PTP1B is the primary protein-tyrosine phosphatase capable of dephosphorylating c-Src in several human breast cancer cell lines and suggests a regulatory role for PTP1B in the control of c-Src kinase activity.", "domain": "chemistry", "round": 3} +{"url": "https://www.worldenergydata.org/climate-change-has-likely-begun-to-suffocate-the-worlds-fisheries/", "date": "2023-12-08T05:47:35Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100724.48/warc/CC-MAIN-20231208045320-20231208075320-00715.warc.gz", "language_score": 0.9376929402351379, "token_count": 353, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__309744802", "lang": "en", "text": "By 2080, around 70% of the world’s oceans could be suffocating from a lack of oxygen as a result of climate change, potentially impacting marine ecosystems worldwide.\nThe new models find mid-ocean depths that support many fisheries worldwide are already losing oxygen at unnatural rates and passed a critical threshold of oxygen loss in 2021.\nOceans carry dissolved oxygen as a gas, and just like land animals, aquatic animals need that oxygen to breathe. But as the oceans warm due to climate change, their water can hold less oxygen. Scientists have been tracking the oceans’ steady decline in oxygen for years, but a new study provides new, pressing reasons to be concerned sooner rather than later.\nRising temperatures lead to warmer waters that can hold less dissolved oxygen, which creates less circulation between the ocean’s layers. The middle layer of the ocean is particularly vulnerable to deoxygenation because it is not enriched with oxygen by the atmosphere and photosynthesis like the top layer, and the most decomposition of algae—a process that consumes oxygen—occurs in this layer.\n“This zone is actually very important to us because a lot of commercial fish live in this zone,” says Yuntao Zhou, an oceanographer at Shanghai Jiao Tong University and lead study author.\n“Humanity is currently changing the metabolic state of the largest ecosystem on the planet, with really unknown consequences for marine ecosystems,” he said. “That may manifest in significant impacts on the ocean’s ability to sustain important fisheries.”\nEven if global warming were to reverse, allowing concentrations of dissolved oxygen to increase, “whether dissolved oxygen would return to pre-industrial levels remains unknown.”", "domain": "chemistry", "round": 3} +{"url": "https://www.antibodies-online.com/abstract/Polymerase+(RNA)+III+(DNA+Directed)+Polypeptide+C+(62kD)+(POLR3C)+Protein/", "date": "2019-02-22T11:23:00Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-09/segments/1550247515149.92/warc/CC-MAIN-20190222094419-20190222120419-00513.warc.gz", "language_score": 0.8675880432128906, "token_count": 447, "dump": "CC-MAIN-2019-09", "global_id": "webtext-fineweb__CC-MAIN-2019-09__0__80233167", "lang": "en", "text": "Use your antibodies-online credentials, if available.\nNo Products on your Comparison List.\nYour basket is empty.\nFind out more\nDNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Additionally we are shipping POLR3C Antibodies (73) and many more products for this protein.\nShowing 5 out of 7 products:\nmonogenic or digenic POLR3A and POLR3C deficiencies confer increased susceptibility to severe VZV disease in otherwise healthy children, providing evidence for an essential role of a DNA sensor in human immunity\nThe study reports the crystal structure of RPC62.\nDNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other members of the subcomplex RNA Pol III binding to the TFIIIB- DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity).\npolymerase (RNA) III (DNA directed) polypeptide C (62kD)\n, DNA-directed RNA polymerase III subunit RPC3-like\n, DNA-directed RNA polymerase III subunit C\n, DNA-directed RNA polymerase III subunit RPC3\n, RNA polymerase III subunit C3\n, DNA-directed III 62 kDa polypeptide\n, RNA polymerase III 62 kDa subunit", "domain": "chemistry", "round": 3} +{"url": "http://www.mdpi.com/1996-1944/7/9/6224", "date": "2018-01-19T02:25:53Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-05/segments/1516084887692.13/warc/CC-MAIN-20180119010338-20180119030338-00431.warc.gz", "language_score": 0.8818199038505554, "token_count": 626, "dump": "CC-MAIN-2018-05", "global_id": "webtext-fineweb__CC-MAIN-2018-05__0__40656960", "lang": "en", "text": "Pre-Saturation Technique of the Recycled Aggregates: Solution to the Water Absorption Drawback in the Recycled Concrete Manufacture†\nAbstractThe replacement of natural aggregates by recycled aggregates in the concrete manufacturing has been spreading worldwide as a recycling method to counteract the large amount of construction and demolition waste. Although legislation in this field is still not well developed, many investigations demonstrate the possibilities of success of this trend given that concrete with satisfactory mechanical and durability properties could be achieved. However, recycled aggregates present a low quality compared to natural aggregates, the water absorption being their main drawback. When used untreated in concrete mix, the recycled aggregate absorb part of the water initially calculated for the cement hydration, which will adversely affect some characteristics of the recycled concrete. This article seeks to demonstrate that the technique of pre-saturation is able to solve the aforementioned problem. In order to do so, the water absorption of the aggregates was tested to determine the necessary period of soaking to bring the recycled aggregates into a state of suitable humidity for their incorporation into the mixture. Moreover, several concrete mixes were made with different replacement percentages of natural aggregate and various periods of pre-saturation. The consistency and compressive strength of the concrete mixes were tested to verify the feasibility of the proposed technique. View Full-Text\nScifeed alert for new publicationsNever miss any articles matching your research from any publisher\n- Get alerts for new papers matching your research\n- Find out the new papers from selected authors\n- Updated daily for 49'000+ journals and 6000+ publishers\n- Define your Scifeed now\nGarcía-González, J.; Rodríguez-Robles, D.; Juan-Valdés, A.; Morán-del Pozo, J.M.; Guerra-Romero, M.I. Pre-Saturation Technique of the Recycled Aggregates: Solution to the Water Absorption Drawback in the Recycled Concrete Manufacture. Materials 2014, 7, 6224-6236.\nGarcía-González J, Rodríguez-Robles D, Juan-Valdés A, Morán-del Pozo JM, Guerra-Romero MI. Pre-Saturation Technique of the Recycled Aggregates: Solution to the Water Absorption Drawback in the Recycled Concrete Manufacture. Materials. 2014; 7(9):6224-6236.Chicago/Turabian Style\nGarcía-González, Julia; Rodríguez-Robles, Desirée; Juan-Valdés, Andrés; Morán-del Pozo, Julia M.; Guerra-Romero, M. I. 2014. \"Pre-Saturation Technique of the Recycled Aggregates: Solution to the Water Absorption Drawback in the Recycled Concrete Manufacture.\" Materials 7, no. 9: 6224-6236.", "domain": "chemistry", "round": 3} +{"url": "http://monet.fns.uniba.sk/vl/file_top.php?file=3503", "date": "2023-03-30T11:51:22Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-14/segments/1679296949181.44/warc/CC-MAIN-20230330101355-20230330131355-00715.warc.gz", "language_score": 0.9190002679824829, "token_count": 437, "dump": "CC-MAIN-2023-14", "global_id": "webtext-fineweb__CC-MAIN-2023-14__0__142054666", "lang": "en", "text": "|ATO3 encoding a putative outward ammonium transporter is an RTG-independent retrograde responsive gene regulated by GCN4 and the Ssy1-Ptr3-Ssy5 amino acid sensor system.|\nGuaragnella N, Butow RA\nJournal of Biological Chemistry (2003)\nCategory: retrograde signalling ¤ Added: Sep 23, 2004 ¤ Rating: ◊◊\nRespiratory deficient yeast cells such as rhoo petites activate an inter-organelle signaling pathway called retrograde regulation. This results in changes in the expression of a subset of nuclear genes leading to major reconfigurations of metabolism that enable cells to adapt to the respiratory deficient state. Previous studies have focused on the role of three positive regulatory factors in the retrograde pathway, Rtg1p, Rtg2p, and Rtg3p, which are essential for both basal and elevated expressions of some, but not all, retrograde responsive genes. Here we characterize the retrograde regulation of one of those genes, ATO3, whose elevated expression in rhoo petites is largely independent of RTG gene function. ATO3 encodes a member of the YaaH family of proteins that is a putative outward ammonium transporter. We show that Ato3p-green fluorescent protein is preferentially localized to the plasma membrane of mother cells. rhoo petites express more Ato3p-green fluorescent protein in their plasma membrane than do rho+ cells, consistent with the elevated level of ATO3 transcripts in rhoo cells. We find that ATO3 expression has two levels of control, both of which are connected to amino acid sensing and regulation. The first involves GCN4, which is required for the bulk of ATO3 expression. The second involves the Ssy1-Ptr3-Ssy5 amino acid sensor system, which is preferentially required for elevated ATO3 expression in rhoo cells. We propose that ATO3 is induced in rhoo cells to eliminate the excess ammonia that arises because of a potential defect in ammonia assimilation in those cells.", "domain": "chemistry", "round": 3} +{"url": "https://www.ajol.info/index.php/ajb/article/view/92426", "date": "2022-01-24T17:04:50Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-05/segments/1642320304572.73/warc/CC-MAIN-20220124155118-20220124185118-00647.warc.gz", "language_score": 0.9088611602783203, "token_count": 396, "dump": "CC-MAIN-2022-05", "global_id": "webtext-fineweb__CC-MAIN-2022-05__0__149206218", "lang": "en", "text": "Combined effects of 1-methyl cyclopropene (1-MCP) and modified atmosphere packaging (MAP) on different ripening stages of persimmon fruit during storage\nThe aim of this study is to evaluate the combined effects of 1-methyl cyclopropene (1-MCP) applications and modified atmosphere packaging (MAP) to improve the storability of two different harvest maturity stages of ‘Harbiye’ persimmon fruits during 90 days storage at 1°C. For this purpose, 1-MCP, an ethylene action blocker was applied before MAP storage. ‘Harbiye’ persimmon fruits were stored for 90 days at 1°C and 90% relative humidity (RH) under two different MAPs after being exposed to 2 ìl l-1 1-MCP for 12 h or not exposed to 2 ìl l-1 1-MCP for 12 h (control). ‘Harbiye’ fruit firmness, total soluble solids (TSS) content, pH, titratable acidity (TA), color (Ho) value and ethylene production changes were examined through the efficacy of 1-MCP and MAP treatment. 1-MCP-treated fruits delayed two different harvest maturity, persimmon fruits flesh firmness, and combination of 1-MCP with MAPA and MAPB reduced the ethylene production rate during storage. Treatment of 1-MCP improved storability of persimmon fruits more effectively than MAP storage. However, the results indicated that additional improvement in storage could be obtained by a combination of 1-MCP treatment followed by MAP storage. 1-MCP application maintained fruit firmness more effectively in less mature fruits more effectively than in fully mature fruits.\nKey words: Ethylene, harvest, maturity, modified atmosphere, persimmon, 1- methylcyclopropene (1-MCP).", "domain": "chemistry", "round": 3} +{"url": "https://www.sae.org/publications/technical-papers/content/2008-01-2875/", "date": "2019-02-22T14:25:18Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-09/segments/1550247518425.87/warc/CC-MAIN-20190222135147-20190222161147-00375.warc.gz", "language_score": 0.9268395900726318, "token_count": 268, "dump": "CC-MAIN-2019-09", "global_id": "webtext-fineweb__CC-MAIN-2019-09__0__194587245", "lang": "en", "text": "A Comparison of Lithium-Ion and Lead-Acid Aircraft Batteries 2008-01-2875\nIn recent years, a tremendous interest has spawned towards adapting Lithium-Ion battery technology for aircraft applications. Lithium-Ion technology is already being used in some military aircraft (e.g., the F-22, F-35 and the B-2) and it has also been selected as original equipment for large commercial aircraft (e.g., the Airbus A380 and Boeing B787). The advantages of Lithium-Ion technology over Lead-Acid and Nickel-Cadmium technologies are higher specific energy (Wh/kg) and energy density (Wh/L), and longer cycle life. Saving weight is especially important in aircraft applications, because it can boost fuel economy and increase mission capability. Disadvantages of Lithium-Ion technology include higher initial cost, limited calendar/float life, inferior low temperature performance, and more severe safety hazards. This paper will present a direct comparison of a 24-Volt, 28Ah Lead-Acid and a 24-volt, 28Ah Lithium-Ion aircraft battery. Performance data under various temperature conditions and rates of discharge are reported. Conclusions regarding the future of Lithium-Ion aircraft batteries are also included.", "domain": "chemistry", "round": 3} +{"url": "https://www.genetex.com/Product/Detail/TNIK1-antibody/GTX16756", "date": "2019-03-25T03:17:23Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-13/segments/1552912203548.81/warc/CC-MAIN-20190325031213-20190325053213-00382.warc.gz", "language_score": 0.844525158405304, "token_count": 344, "dump": "CC-MAIN-2019-13", "global_id": "webtext-fineweb__CC-MAIN-2019-13__0__12328483", "lang": "en", "text": "Preservative: 0.02% Sodium Azide; Constituents: PBS\nStore as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.\n1 mg/ml (Please refer to the vial label for the specific concentration.)\nSynthetic peptide: QNQVQSLPAGSAEP, corresponding to C terminal amino acids 421-434 of 47 kDa Mouse TNIK1.\nProtein A purified\nFor laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.\nTyrosine Kinase, Non-Receptor, 1,Kos1,Tnk1A,Tnk1B,Tnk1\nTnk1 is a nonreceptor protein tyrosine kinase (NRPTK) and a new member of the Ack family of NRPTKs. Tnk1 is a ubiquitously expressed 47-kDa protein with autotyrosine kinase activity that is developmentally regulated during embryogenesis. Tnk1 is also upregulated following IL3 withdrawal from factor-dependent murine NSF/N1.H7 cells that undergo apoptosis, suggesting a role in growth inhibition. Data support a negative regulatory role for Tnk1 in regulating the Ras-Raf1-MAPK growth pathway by a mechanism that requires its autotyrosine kinase activity.", "domain": "chemistry", "round": 3} +{"url": "http://lifescience-fecs.org/?p=158", "date": "2022-08-15T19:07:24Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882572198.93/warc/CC-MAIN-20220815175725-20220815205725-00316.warc.gz", "language_score": 0.9333245754241943, "token_count": 1260, "dump": "CC-MAIN-2022-33", "global_id": "webtext-fineweb__CC-MAIN-2022-33__0__159520957", "lang": "en", "text": "Mitochondrial DNA damage would cause disruption of respiratory system chain function resulting in lack of mitochondrial membrane potential and destroying ATP synthesis . inhibit the NF-B pathway and improve the apoptotic approach. Together, our results further support the anticancer activity of CADMN alternatively restorative agent against HCC. and additional edible vegetation . CADMN demonstrated cytotoxic actions against a range of tumor cell lines including A549 (lung), DU145 (prostate), MDA-MB-231 (breasts), MCF-7 (breasts), U266 (myeloma), CCRF-CEM (leukemia), and SGC7901 (gastric) . Furthermore, CADMN offers been shown to lessen tumor development in mice , nevertheless you can find limited research on the result of this substance on HCC. Earlier studies have exposed that CADMN exerts its anticancer activity through alteration of varied pathways such as for example mTOR, STAT3, NF-B and Wnt/-catenin signaling pathways . The purpose of this research is to research the antiproliferative and apoptotic actions of CADMN against HepG2 hepatocellular carcinoma (HCC) cells and likewise, to elucidate the root molecular mechanisms in the proteins level. 2. Methods and Materials 2.1. Substances Cardamonin (CADMN) was from Sigma Aldrich, USA with molecular pounds 270.28 g/mol and purity > 98% and dissolved in DMSO (0.02%) for in vitro function. 5-Fluorouracil (5-FU) was from MP Biomedical, lllkirch, France and dissolved in DMSO (0.02%). All the chemical substances were purchased from Fisher and Sigma with analytical grade. 2.2. Cell Lines Two cell lines had been found in this scholarly research, namely HepG2 human being HCC cells that have been produced from the liver organ tissue of the 15-year-old American adolescent youngster of Western ancestry having a well-differentiated hepatocellular carcinoma and Hs27 human being fibroblast cell range. Both cell lines had been from American Type Tradition Collection (ATCC, Manassas, VA, USA). HepG2 cell range was cultured in EMEM press and Hs27 cells had been cultured in DMEM press, both media including 1% penicillin/streptomycin, 10% fetal bovine serum and taken care of at Phthalylsulfacetamide 37 C incubator with 5% CO2. 2.3. Cell Proliferation MTT Assay The in vitro cytotoxic aftereffect of CADMN was dependant on using the MTT colorimetric assay which really is a microculture tetrazolium sodium (MTT, Sigma, St. Louis, MO, USA) as Phthalylsulfacetamide referred to by Mosmann . In short, cells (5 104 cells/well) had been treated with different concentrations of CADMN or 5-FU and incubated for 24 h, 48 h and 72 h. After that, 20 L of MTT option (5 mg/mL) was put into each well as well as the dish was re-incubated for 4 h. After that, 100 L of DMSO was utilized to dissolve the formazan crystals. The absorbance was assessed having a microplate audience (Tecan, Infinite M1000) at Phthalylsulfacetamide 570 nm. 5-FU was used like a positive medication and control of research with this test. The inhibition aftereffect of substances was performed in triplicates and indicated as IC50 worth. The cell inhibition percentage was approximated the following: < 0.05 was considered as significant statistically. Data had been examined with graph pad prism, edition 5 for home windows and SPSS Statistic 20 (SPSS Inc., Chicago, IL, USA). 3. Outcomes 3.1. Cardamonin Inhibits Cell Proliferation of HepG2 Cells The cytotoxic aftereffect of CADMN against human being HCC cell range HepG2 and regular fibroblast cells Hs27 was analyzed by MTT colorimetric assay. CADMN and 5-FU considerably inhibited the development of HepG2 cells inside a dosage- and time-dependent way (Shape 1a,b). As demonstrated in Shape 1c, the half-maximal inhibition focus (IC50) of CADMN-treated HepG2 cells at 24, 48 or 72 h was 307.6 131.7 M, 217.1 35.7 M and 17.1 0.592 M, respectively. 5-Fluorouracil was utilized like a positive control and exhibited a far more pronounced cytotoxic impact against HepG2 cells with an IC50 of 256.7 76.87 M, 85.4 4.50 M and 14.6 4.61 M after 24, 48 and 72 h of treatment, respectively (Shape 1d). The IC50 of Phthalylsulfacetamide CADMN-treated HepG2 after 72 h was considerably less than the IC50 of CADMN after 24 h and 48 h (Shape 1c). Consequently, the IC50 of 72 h was selected to be looked into in the downstream assays like the molecular system. Alternatively, CADMN demonstrated high selectivity and much less Phthalylsulfacetamide cytotoxic influence on Hs27 regular fibroblast cells with an IC50 225.7 15.53 M at 72 h when compared with 5-FU (IC50 11.53 3.075) (Desk 1). Open up in PDGFA another window Shape 1 Cytotoxic aftereffect of (a) Cardamonin (CADMN) and (b) 5-Fluorouracil (5-FU) against HepG2 cells. Different concentrations of CADMN and 5-FU had been put into the HepG2 cells as cure for different schedules (24, 48.", "domain": "chemistry", "round": 3} +{"url": "https://pubmed.ncbi.nlm.nih.gov/31552591/", "date": "2023-12-03T09:14:18Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100489.16/warc/CC-MAIN-20231203062445-20231203092445-00190.warc.gz", "language_score": 0.8991180062294006, "token_count": 252, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__203660529", "lang": "en", "text": "Schisandrin A (Sch A) is one of the principal bioactive lignans isolated from Fructus schisandrae. In this study, we demonstrated its protective effect and biochemical mechanism of action in a 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine-induced mouse model of Parkinson's disease. Sch A significantly ameliorated behavioural abnormalities and increased the number of nigral dopaminergic neurons detected by tyrosine hydroxylase immunohistochemistry. Pre-treatment with Sch A significantly decreased the levels of the inflammatory mediators IL-6, IL-1β, and TNF-α and markedly improved antioxidant defences by inhibiting the activity of MDA and increasing that of SOD. Furthermore, Sch A activated expression of the autophagy-related proteins LC3-II, beclin1, parkin, and PINK1 and increased mTOR expression. Taken together, these findings indicate that Sch A has neuroprotective effects against the development of Parkinson's disease via regulation of brain autophagy.\nKeywords: Autophagy; LC3-II; Parkinson’s disease; Schizandrin A.", "domain": "chemistry", "round": 3} +{"url": "https://autopartsstore.lk/Shop/liqui-moly-atf-additive/", "date": "2024-04-15T15:37:07Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712296817002.2/warc/CC-MAIN-20240415142720-20240415172720-00235.warc.gz", "language_score": 0.8941213488578796, "token_count": 1244, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__150272584", "lang": "en", "text": "LIQUI MOLY ATF Additive 250ml\nLIQUI MOLY ATF Additive is intended to improve transmission performance, including friction modifiers, viscosity improvers, and detergents.\n1 in stock\nLIQUI MOLY ATF Additive 250ml.\nLIQUI MOLY offers a range of automatic transmission fluid (ATF) additive that are designed to improve the performance and longevity of automatic transmissions. These additive are intended to be added to the existing ATF in the transmission and are compatible with all types of automatic transmissions, including those with continuously variable transmissions (CVT).\nThe LIQUI MOLY ATF additive are formulated with a variety of ingredients that are intended to improve transmission performance, including friction modifiers, viscosity improvers, and detergents. The exact formulation of the additive will depend on the specific product, and the manufacturer offers a range of additive to address different transmission issues.\nTo use LIQUI MOLY ATF additive, simply add the recommended amount of product to the transmission fluid according to the manufacturer’s instructions. The product will mix with the existing ATF and circulate through the transmission, improving performance and protecting against wear.\nLIQUI MOLY ATF Additive are specially formulated to enhance the performance and protect the transmission system. These additives incorporate a range of advanced features to deliver optimal results.\nOne of the key features of LIQUI MOLY ATF Additive is their ability to improve the lubricating properties of the transmission fluid. The additives contain high-quality friction modifiers and anti-wear agents that reduce friction between moving parts, resulting in smoother gear shifts and reduced wear and tear on transmission components.\nAdditionally, It helps to prevent the formation of harmful deposits and sludge within the transmission system. The advanced detergents in the additives effectively clean and dissolve existing deposits, ensuring optimal transmission performance and preventing potential issues such as sticking valves or blocked passages.\nFurthermore, these additives are designed to improve the thermal stability of the transmission fluid. By reducing heat buildup and maintaining proper fluid viscosity, LIQUI MOLY ATF Additive help to prolong the lifespan of the transmission, even under high-stress conditions.\nUsing LIQUI MOLY ATF Additive provides numerous benefits that improve transmission performance and overall driving experience.\nFirstly, these additives help to reduce friction and wear within the transmission system. By enhancing the lubricating properties of the fluid, LIQUI MOLY ATF Additive promote smoother gear shifts and reduce the risk of damage to transmission components. This results in improved transmission efficiency, reduced noise, and a more comfortable driving experience.\nAdditionally, It assist in preventing the formation of deposits and sludge. By keeping the transmission system clean, the additives ensure optimal fluid flow and prevent potential issues caused by blocked passages or sticking valves. This leads to improved transmission response and reliability.\nMoreover, LIQUI MOLY ATF Additive contribute to the overall longevity of the transmission. By reducing friction and wear, these additives help to extend the lifespan of critical components, such as gears and bearings. This can result in reduced maintenance costs and a longer-lasting transmission.\nLIQUI MOLY ATF Additive Price in Sri Lanka\nThe price of LIQUI MOLY ATF Additive in Sri Lanka may vary depending on the retailer and the specific product variant. However, considering the significant benefits they offer, the cost is a worthwhile investment. On average, LIQUI MOLY ATF Additive can range from Rs. 2,000 to Rs. 5,500 per bottle in Sri Lanka. It is recommended to check with authorized LIQUI MOLY dealers or reputable automotive stores for the most accurate pricing information.\nHow to Use LIQUI MOLY ATF Additive\nUsing LIQUI MOLY ATF Additive is a straightforward process. Follow these steps to ensure optimal results:\n- Check the transmission fluid level and ensure it is within the recommended range. If necessary, top up the fluid to the proper level.\n- Shake the LIQUI MOLY ATF Additive bottle well before use to ensure proper mixing of the additives.\n- With the engine running and the transmission in park or neutral, pour the recommended amount of LIQUI MOLY ATF Additive into the transmission fluid filler tube. Consult the product packaging or the manufacturer’s instructions for the appropriate dosage.\n- Replace the transmission fluid filler cap securely.\n- Drive the vehicle for at least 20-30 minutes to allow the additives to circulate and mix thoroughly with the transmission fluid. During this time, the additives will work to enhance the lubrication and cleaning properties of the fluid.\n- Monitor the transmission’s performance, paying attention to smoother gear shifts, reduced noise, and improved overall operation.\nViscosity at 40 °C: ~ 166 mm²/s DIN 51562\nViscosity at 100 °C: ~ 26 mm²/s DIN 51562\nDensity: 0,888 g/ml\nRefractive index at 20 °C: ~ 1,478\nAreas of application\nSuitable for power-steering and automatic transmissions that are filled with ATF II and ATF III oils.\nMix ATF Additive into the gear oil using the dipstick. 250 ml are sufficient for up to 8 liters of oil.\nLIQUI MOLY ATF Additive provide an effective solution to optimize transmission performance and extend its lifespan. With their advanced features, multiple benefits, and reasonable price, It is a valuable addition to your vehicle maintenance routine. By following the usage guide and incorporating LIQUI MOLY ATF Additive into your regular maintenance schedule, you can enjoy smoother gear shifts, reduced wear, and enhanced transmission reliability. Invest in LIQUI MOLY ATF Additive and experience the difference in your transmission’s performance for a more enjoyable and trouble-free driving experience.", "domain": "chemistry", "round": 3} +{"url": "https://www.bio-rad.com/en-us/prime-pcr-assays/assay/qhsacep0052053-primepcr-probe-assay-duox1-human", "date": "2019-11-15T11:51:25Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-47/segments/1573496668618.8/warc/CC-MAIN-20191115093159-20191115121159-00351.warc.gz", "language_score": 0.8752519488334656, "token_count": 300, "dump": "CC-MAIN-2019-47", "global_id": "webtext-fineweb__CC-MAIN-2019-47__0__154039415", "lang": "en", "text": "This is the amplicon context sequence in accordance with the minimum information for the publication of real-time quantitative PCR experiements (MIQE) guidelines. For more details, please refer to the following publication, \"Primer Sequence Disclosure: A Clarification of the MIQE Guidelines.\"\nReal-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.\nPrimePCR™ PreAmp for Probe Assay: DUOX1, Human\nPrimePCR™ Template for Probe Assay: DUOX1, Human\nThe protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter thyroperoxidase and a peroxide generating system that includes this encoded protein and DUOX2. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq Jul 2008]\nProducts used to generate validation data:\nAmplification of cDNA generated from universal RNA.\nMelt curve analysis of above amplification.\nStandard curve generated using 20 million copies of template diluted 10 fold to 20 copies.", "domain": "chemistry", "round": 3} +{"url": "https://biology.stackexchange.com/questions/9061/confusion-regarding-photosynthesis-and-respiration-in-plants/9064", "date": "2021-07-31T01:47:05Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-31/segments/1627046154042.23/warc/CC-MAIN-20210731011529-20210731041529-00620.warc.gz", "language_score": 0.9182064533233643, "token_count": 262, "dump": "CC-MAIN-2021-31", "global_id": "webtext-fineweb__CC-MAIN-2021-31__0__22464004", "lang": "en", "text": "You haven't directed us to any evidence for your assertion, so it is difficult to evaluate.\nI'm not a plant physiologist, so I will argue from first principles:\nphotosynthesis consumes CO2 and produces O2:\n6CO2 +6H2O -> C6H12O6 + 6O2\nrespiration consumes O2 and produces CO2:\nC6H12O6 + 6O2 -> 6CO2 +6H2O\nPlants do both of these things at the same time for at least part of the day. During the day, in a growing plant, photosynthesis will exceed respiration: a lot of the fixed carbon is fed into anabolic processes to produce \"plant stuff\"; polysaccharides, proteins, nucleic acids. This means that the plant will be a net producer of O2 and a net consumer of CO2. At night there is, of course, no photosynthesis and respiration will dominate and the plant will be a net producer of CO2 and a net consumer of O2.\nAt certain times of the day, twilight for example, there will be a transition between these two states, and the plant will pass through a state where there will be no net flux in either of the gases.", "domain": "chemistry", "round": 3} +{"url": "https://biofyl.com/services/bioassay-development-and-validation/", "date": "2023-01-29T23:00:18Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-06/segments/1674764499768.15/warc/CC-MAIN-20230129211612-20230130001612-00840.warc.gz", "language_score": 0.8034971356391907, "token_count": 348, "dump": "CC-MAIN-2023-06", "global_id": "webtext-fineweb__CC-MAIN-2023-06__0__28281521", "lang": "en", "text": "Bioassay development and validation can be done in the following areas at Biofyl Scientific Research:\nOur Bioassay Development and Validation at BSR includes: Kinase Phosphorylation (e.g. SMAD, Akt, PI3, HER2/ErbB2, Erk1/2), Cell Differentiation (Mesenchymal: Osteogenic, Adipogenic and Chondrogenic; Hematopoietic Stem cells: CFU-E, BFU-E, CFU-GEMM, CFU-GM, CFU-G, CFU-M). Cell Cycle Determination ( P21), Serum Complement (CH50), Platelet Function (aggregation, growth factor release, p-selectin expression, osmotic stress), Lymphocyte and Granulocyte Function (Stimulation, Cytotoxicity, Cell number, Viability, Apoptosis), Cell Migration (modified Boyden chamber, membrane and semisolid media) and Stem Cell Function (colony formation and differentiation).\nBSR will qualify commercial immunoassay kits when available. Compendial assays or Commercial assays with sufficient documentation on performance and acceptance criteria are employed by BSR after qualification for sample matrix and any special conditions for the intended application. Other assays are validated according to best industry standards including: FDA “ Guidance for Industry: Bioanalytical Method Validation” CDER 2001; and ICH Q2(R1) “Validation of Analytical Procedures: Text and Methodology”.\nIn addition, Biofyl Scientific Research also offers the following services:", "domain": "chemistry", "round": 3} +{"url": "https://rd.springer.com/article/10.1007/s11033-013-2519-1", "date": "2018-08-16T19:25:24Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-34/segments/1534221211167.1/warc/CC-MAIN-20180816191550-20180816211550-00001.warc.gz", "language_score": 0.7358565330505371, "token_count": 1005, "dump": "CC-MAIN-2018-34", "global_id": "webtext-fineweb__CC-MAIN-2018-34__0__166426540", "lang": "en", "text": "Direct amplification of new cellulase genes from woodland soil purified DNA\n- 383 Downloads\nEight genes encoding cellulolytic enzymes were obtained by direct PCR amplification of genomic DNA recovered from woodland soil samples. The direct amplifications were carried out by using primers designed from available online cellulase nucleotide sequences. The isolated genes were all different from each other and homologous to endo-β-1,4-glucanases of Bacillus subtilis. The cellulases were functionally expressed in Escherichia coli and tested on soluble substrate at 37 and 60 °C, showing different cellulolytic activities. Among these, the enzyme renamed CelWS6 exhibited good activity at higher temperatures. Further analysis of CelWS6 showed a high performance in acid environments (between pH 4.0 and 6.0) and at elevated temperatures with its maximum activity at pH 5.0 and 50 °C. At the optimum pH, it was very stable since more than 80 % of its original activity was maintained after an incubation of 120 min at 60 °C. Because the cellulases had different cellulolytic activities, but similar amino acid sequences, it was possible to assess the relationship between sequence and protein function.\nKeywordsCellulases Soil recovered DNA Bacillus subtilis Thermostability pH profile\nThis work was supported by “Fondo per la promozione delle espressioni di interesse dei privati e azioni conseguenenti” instituted by Lombardia region (Italy) (Project number: 12771762).\n- 1.Allgaier M, Reddy A, Park JI, Ivanova N, D’haeseleer P, Lowry S, Sapra R, Hazen TC, Simmons BA, VanderGheynst JS, Hugenholtz P (2010) Targeted discovery of glycoside hydrolases from a switchgrass-adapted compost community. PLoS One 5:e8812. doi: 10.1371/journal.pone.0008812 PubMedCrossRefGoogle Scholar\n- 3.Doyle JJ, Doyle JL (1987) A rapid isolation procedure for small quantities of fresh leaf tissue. Phytochem Bull 19:11–15Google Scholar\n- 4.Ferrer M, Golyshina OV, Chernikova TN, Khachane AN, Reyes-Duarte D, Martins Dos Santos VAP, Strompl C, Elborough K, Jarvis G, Neef A, Yakimov MM, Timmis KN, Golyshin PN (2005) Novel hydrolase diversity retrieved from a metagenome library of bovine rumen microflora. Environ Microbiol 7:1996–2010. doi: 10.1111/j.1462-2920.2005.00920 PubMedCrossRefGoogle Scholar\n- 5.Gomes J, Steiner W (2004) The biocatalytic potential of extremophiles and extremozymes. Food Technol. Biotechnol 42:223–235Google Scholar\n- 7.Hess M, Sczyrba A, Egan R, Kim TW, Chokhawala H, Schroth G, Luo S, Clark DS, Chen F, Zhang T, Mackie RI, Pennacchio LA, Tringe SG, Visel A, Woyke T, Wang Z, Rubin EM (2011) Metagenomic discovery of biomass-degrading genes and genomes from cow rumen. Science 331:463–467. doi: 10.1126/science.1200387 PubMedCrossRefGoogle Scholar\n- 17.Sambrook J, Fritsch EF, Maniatis T (1989) Molecular cloning: A laboratory manual, 2nd edn. Cold Spring Harbor Laboratory Press, New YorkGoogle Scholar\n- 18.Santos CR, Paiva JH, Sforça ML, Neves JL, Navarro RZ, Cota J, Akao PK, Hoffmam ZB, Meza AN, Smetana JH, Nogueira ML, Polikarpov I, Xavier-Neto J, Squina FM, Ward RJ, Ruller R, Zeri AC, Murakami MT (2012) Dissecting structure-function-stability relationships of a thermostable GH5-CBM3 cellulase from Bacillus subtilis 168. Biochem. J 441:95–104. doi: 10.1042/BJ20110869 PubMedCrossRefGoogle Scholar\n- 21.Teather RM, Wood PJ (1982) Use of Congo red-polysaccharide interactions in enumeration and characterization of cellulolytic bacteria from the bovine rumen. Appl Environ Microbiol 43:777–780Google Scholar", "domain": "chemistry", "round": 3} +{"url": "https://eprints.ncl.ac.uk/127845", "date": "2021-12-03T15:52:28Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-49/segments/1637964362891.54/warc/CC-MAIN-20211203151849-20211203181849-00154.warc.gz", "language_score": 0.7214083671569824, "token_count": 354, "dump": "CC-MAIN-2021-49", "global_id": "webtext-fineweb__CC-MAIN-2021-49__0__66095687", "lang": "en", "text": "Browse by author\nLookup NU author(s): Clayton Price,\nEmeritus Professor Bill Clegg\nFull text for this publication is not currently held within this repository. Alternative links are provided below where available.\nTwo five-unit Linear compounds, [NC5H4. C5H4N . B10H12. NC5H4. C5H4N] and [Me2S . B10H12. NC4H4N . B10H12. SMe2], have been isolated from the reactions of [6,9-(SMe2)(2)-arachno-B10H12] with 4,4'-bipyridyl and pyrazine (1,4-diazabenzene), respectively, and are characterised by single-crystal X-ray diffraction analysis. (C) 1999 Elsevier Science S.A. All rights reserved.\nAuthor(s): Londesborough MGS, Price C, Thornton-Pett M, Clegg W, Kennedy JD\nPublication type: Article\nPublication status: Published\nJournal: Inorganic Chemistry Communications\nPrint publication date: 17/08/1999\nISSN (print): 1387-7003\nISSN (electronic): 1879-0259\nPublisher: Elsevier BV\nAltmetrics provided by Altmetric", "domain": "chemistry", "round": 3} +{"url": "https://era.library.ualberta.ca/search?facets%5Ball_subjects_sim%5D%5B%5D=Growth-hormone", "date": "2019-04-24T05:53:22Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-18/segments/1555578633464.75/warc/CC-MAIN-20190424054536-20190424080536-00413.warc.gz", "language_score": 0.8901987075805664, "token_count": 269, "dump": "CC-MAIN-2019-18", "global_id": "webtext-fineweb__CC-MAIN-2019-18__0__190435630", "lang": "en", "text": "SearchSkip to Search Results\nMolecular cloning, pharmacological characterization and brain mapping of the melanocortin 4 receptor in the goldfish: Involvement in the control of food intakeDownload\nWe report cloning, pharmacological characterization, tissue distribution, detailed brain mapping, and role in control of food intake of melanocortin 4 receptor in goldfish (gMC4R). The gMC4R protein has 68% identity with the human ortholog and is conserved in important functional domains....\nThe evolution of GnRH and the role of multiple forms within the brain are examined. Three forms of GnRH were purified from the brain of Pacific herring (Clupea harengus pallasi) and characterized using Edman degradation and mass spectrometry. Two forms correspond with the known structures of...\nPrimary structure of a novel gonadotropin-releasing hormone (GnRH) in the brain of a teleost, PejerreyDownload\nThe neuropeptide GnRH is the major regulator of reproduction in vertebrates acting as a first signal from the hypothalamus to pituitary gonadotropes. Three GnRH molecular variants were detected in the brain of a fish, pejerrey (Odontesthes bonariensis), using chromatographic and immunological...", "domain": "chemistry", "round": 3} +{"url": "https://www.conicet.gov.ar/new_scp/detalle.php?keywords=&id=12526&inst=yes&articulos=yes&detalles=yes&art_id=602624", "date": "2020-12-03T18:03:29Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-50/segments/1606141729522.82/warc/CC-MAIN-20201203155433-20201203185433-00259.warc.gz", "language_score": 0.7485853433609009, "token_count": 395, "dump": "CC-MAIN-2020-50", "global_id": "webtext-fineweb__CC-MAIN-2020-50__0__214805186", "lang": "en", "text": "INSTITUTO DE QUIMICA, FISICA DE LOS MATERIALES, MEDIOAMBIENTE Y ENERGIA\nUnidad Ejecutora - UE\nAn efficient method for conjugation of a lipopolysaccharide from Salmonella enterica sv. Minnesota with probes bearing hydrazine or amino functional groups\nDIEGO PALLAROLA; FERNANDO BATTAGLINI\nAño: 2008 vol. 381 p. 53 - 53\nA conjugation method for coupling probes bearing hydrazine or primary amino groups to a lipopolysaccharide (LPS) is described. LPS is modified through the hydroxyl groups present in its O-antigen moiety by activation with cyanogen bromide in aqueous acetone using triethylamine to enhance the electrophilicity of CNBr. The method yields conjugates with good labeling ratios, preserving the endotoxic activity of the lipid A moiety, which in blood exerts pleiotropic effects on many tissues and organs, resulting in multiple-organ damage, circulatory collapse, and death. Conjugation of smooth-form LPS from Salmonella enterica sv. Minnesota to dansyl hydrazine yielded a labeling ratio of 330 nmol dansyl/mg LPS, with nearly no loss of the original endotoxic activity. In the case of horseradish peroxidase, in which a spacer was introduced, the ratio was 28 nmol HRP/mg of LPS, preserving 65% of the original endotoxic activity. This work shows that under these conditions of CNBr activation, the labeling process has practically no effect on the endotoxic behavior of LPS. The method can be used effectively for the conjugation of LPS to probes bearing primary amino, hydrazine, or hydrazide functional groups.", "domain": "chemistry", "round": 3} +{"url": "https://www.ornl.gov/news?f%5B0%5D=all_news_news_type%3AFeatures&f%5B1%5D=related_news_topics%3A1163&f%5B2%5D=related_news_topics%3A1168&f%5B3%5D=related_news_topics%3A1173&f%5B4%5D=related_news_topics%3A1201&f%5B5%5D=related_news_topics%3A1202&f%5B6%5D=related_news_topics%3A1204", "date": "2020-05-31T11:11:08Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-24/segments/1590347413097.49/warc/CC-MAIN-20200531085047-20200531115047-00134.warc.gz", "language_score": 0.9342421889305115, "token_count": 347, "dump": "CC-MAIN-2020-24", "global_id": "webtext-fineweb__CC-MAIN-2020-24__0__11507033", "lang": "en", "text": "With the rise of the global pandemic, Omar Demerdash, a Liane B. Russell Distinguished Staff Fellow at ORNL since 2018, has become laser-focused on potential avenues to COVID-19 therapies.\nSuman Debnath, a researcher at ORNL, has been elevated to the grade of senior member of the Institute of Electrical and Electronics Engineers (IEEE).\nResearchers at the Department of Energy’s Oak Ridge National Laboratory (ORNL) in late February demonstrated a 20-kilowatt bi-directional wireless charging system installed on a UPS medium-duty, plug-in hybrid electric delivery truck.\nIn the Physics Division of the Department of Energy’s Oak Ridge National Laboratory, James (“Mitch”) Allmond conducts experiments and uses theoretical models to advance our understanding of the structure of atomic nuclei, which are made of various combinations of protons and neutrons (nucleons).\nIn the race to identify solutions to the COVID-19 pandemic, researchers at the Department of Energy’s Oak Ridge National Laboratory are joining the fight by applying expertise in computational science, advanced manufacturing, data science and neutron science.\nThe techniques Theodore Biewer and his colleagues are using to measure whether plasma has the right conditions to create fusion have been around awhile.\nBiological membranes, such as the “walls” of most types of living cells, primarily consist of a double layer of lipids, or “lipid bilayer,” that forms the structure, and a variety of embedded and attached proteins with highly specialized functions, including proteins that rapidly and selectively transport ions and molecules in and out of the cell.", "domain": "chemistry", "round": 3} +{"url": "http://www.abbreviations.com/serp.php?st=l-lactate%20dehydrogenase&qtype=3", "date": "2016-02-14T04:05:56Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2016-07/segments/1454701168998.49/warc/CC-MAIN-20160205193928-00158-ip-10-236-182-209.ec2.internal.warc.gz", "language_score": 0.6993649005889893, "token_count": 304, "dump": "CC-MAIN-2016-07", "global_id": "webtext-fineweb__CC-MAIN-2016-07__0__96303161", "lang": "en", "text": "Acronyms that contain the term l-lactate dehydrogenase\nWhat does l-lactate dehydrogenase mean? This page is about the various possible meanings of the acronym, abbreviation, shorthand or slang term: l-lactate dehydrogenase.\nWe've found a total of 50 shorthands for l-lactate dehydrogenase:\nGlucose-6- Phosphate Dehydrogenase\nGlucose 6- Phosphate Dehydrogenase\nPyruvate Dehydrogenase Complex Deficiency\n6-phosphogluconate dehydrogenase, decarboxylating 1\n6-phosphogluconate dehydrogenase, decarboxylating 2\nLow Xanthine Dehydrogenase\nLactate threshold heart rate\nLactic dehydrogenase -high levels correlate with tumour volume in some cancers\nLactate Theshold Heart Rate\nPyruvate Dehydrogenase Phosphatase\nMedium Chain Acylcoa Dehydrogenase\nWhat does l-lactate dehydrogenase mean?\n- L-Lactate Dehydrogenase\n- A tetrameric enzyme that, along with the coenzyme NAD+, catalyzes the interconversion of LACTATE and PYRUVATE. In vertebrates, genes for three different subunits (LDH-A, LDH-B and LDH-C) exist.", "domain": "chemistry", "round": 3} +{"url": "https://www.achrinhibitor.com/2023/01/09/6908/", "date": "2023-12-08T03:59:57Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100710.22/warc/CC-MAIN-20231208013411-20231208043411-00777.warc.gz", "language_score": 0.8843162655830383, "token_count": 893, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__21441732", "lang": "en", "text": "Are also involved in CNS ion homeostasis and fluid secretion. Regulation from the ionic composition of your brain ECF is very important for CNS function, plus the concentrations of specific ions, which include K+ and Ca2+, that regulate neuronal activity, are extremely tightly controlled (Hladky and Barrand, 2016). The BBB has an array of ion transporters that carry Na+, K+, Cl-, HCO3-, Ca2+ as well as other ions. A lot of of these are asymmetrically distributed amongst the luminal and abluminal membranes, contributing to vectorial transport across the BBB (Hladky and Barrand, 2016). Therefore, by way of example, there is certainly proof that a Na+-K+-Cl- cotransporter and also a Na+/H+ exchanger present at the EC luminal membrane and Na+/K+-ATPase in the abluminal membrane are involved within the transcellular transport of Na+ (Betz et al., 1980; Lam et al., 2009; O’Donnell et al., 2004). Through functional coupling of luminal and abluminal transporters and channels, the BBB transports Na+, Cl- and also other ions and connected water from blood into brain, producing 30 of brain interstitial fluid in healthier brain (O’Donnell, 2014). As a result, the BBB contributes to the regulation of ECF volume and composition. How such ion and fluid transport is affected beneath pathological situations is definitely an crucial query in brain edema formation. On the a single hand, energy-dependent transporters which include Na+/K+-ATPase and Ca2+-ATPase fail to sustain the cellular ion homeostasis in infarct core as a consequence of ATP loss. Alternatively, ischemia stimulates Na+-K+-Cl- cotransport and Na+/H+ exchange, top towards the entry of extracellular Na+. When the Na+/K+-ATPase no CA Ⅱ Molecular Weight longer keeps pace with such transport activities, intracellular Na+ accumulation and endothelial swelling occurs (O’Donnell, 2014). Astrocytes also take up the brain Na+ resulting from transendothelial transport, causing cytotoxic edema (O’Donnell, 2014). two.four.three. ABC transporters–ATP-binding cassette (ABC) transporters are a protein superfamily containing 48 members grouped into 7 sub-families according to structural homology. At the BBB, essentially the most important are P-gp (ABCB1), breast cancer resistance protein (ABCG2) and also the multidrug resistance-associated proteins (ABCC1, 2, 4, five and possibly three and six). They’re predominantly localized towards the EC luminal membrane, transporting a wide selection of substrates in the EC cytoplasm back to blood (Mahringer and Fricker, 2016); i.e. a significant role of those transporters should be to act as efflux pumps preventing CNS penetration of lipid-soluble compounds. Such compounds include things like potentially neurotoxic endogenous or xenobiotic molecules. Even so, although ABC transporters have this neuroprotective function (Dallas et al., 2006), in addition they limit the penetration of many drugs into brain (Shen and Zhang, 2010), including potential neuroprotectants. 2.five. Metabolic barrier The BBB also prevents the entry of compounds from blood to brain due to the presence of metabolizing enzymes inside the ECs, pericytes or astrocytes. These incorporate monoamine oxidases, Reactive Oxygen Species drug endopeptidases, aminopeptidases and cholinesterases (Agundez et al., 2014). These may well degrade potentially neuroactive compounds (e.g. circulating catecholamines) just before they can have parenchymal actions. This is a relatively understudied area of analysis in standard brain and in illnesses including stroke.Author Manuscript Author Manuscript Author Manuscript Author ManuscriptProg Neurobiol. Author manuscript; out there in PMC 2019 April 01.Jiang et al.Page2.6. Immune cell traffickingAu.", "domain": "chemistry", "round": 3} +{"url": "https://gite-aveyron-labastide.fr/coal-water-slurry-coal-water-mixture-fired-steam-boiler--15475.html", "date": "2020-11-25T05:04:17Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-50/segments/1606141181179.12/warc/CC-MAIN-20201125041943-20201125071943-00590.warc.gz", "language_score": 0.898313045501709, "token_count": 2228, "dump": "CC-MAIN-2020-50", "global_id": "webtext-fineweb__CC-MAIN-2020-50__0__4365200", "lang": "en", "text": "Coal Water Slurry Fuel Cwsf Fired Steam Boiler Agent. 0 7 Mw Methane Boiler In Japan - coal water slurry (cws) / coal water mixture ( cwm) Coal- water slurry fuel - Wikipedia, the freenCoal-water slurry fuel (CWSF, CWS, CWF) is a fuel consisting of fine coal particles CWS is suitable for existing gas, oil, and coal-fired boilers. is unique in …\nCoal Water Slurry Steam Boiler - ratinger-backstube.de. coal slurry fired boiler – Zozen Boiler. The other workable seams won in sinking were the Five Quarter seam, 178, Main coal…\nwater tube natural coal fired steam boilers. coal fuel steam boiler Industrial Boiler. 2018-3-4·Coal Water Slurry Fuel(CWSF) Steam Boilers-Automization Type Description of Coal Water Slurry Steam Boilers Coal water slurry fuel (CWSF or CWS or CWF) is a fuel which consists of fine coal particles suspended in water.resence of water in CWS reduces harmful emissions into the atmosphere, makes the\nThe key technology and application of retrofitting 65 t/h oil-fired boiler into CWS(coal-water slurry)-fired one was reported.The boiler proper retrofit,the study and design of oil/CWS dual burner and CWS nozzle were also reported.The combustion adjustment tests were\nCoal water slurry fired boiler - CFB boiler, biomass . Coal water slurry fired boiler is the kind of CFB boiler burning coal water slurry. While coal water slurry fluidized suspended efficient clean combustion technology is a revolution in the combustion field. Coal water slurry is a fluid fuel made of 65% coal, 34% water and 1% chemical\nCoal-water mixture fired steam/hot water boiler is the new-generation environmental-protection product. It features Iow fuel cost and less contamination emission. Therefore it …\n2019-11-5 · Pulverized Coal Fired Steam Boilers is an industrial or utility boiler that generates thermal energy by burning pulverized coal (also known as powdered coal or coal dust since it is as fine as face powder in cosmetic makeup) that is blown into the firebox. The basic idea of a firing system using pulverized fuel is to use the whole volume of the furnace for the combustion of solid fuels.\nCoal Water Slurry Fuel Burner Reliable Steam Boiler . 2014-9-3 · Coal Water Slurry Fuel Burner belongs to turbulent burner. Turbulent burner adopts rotary jet design, have a larger spray divergence angle, which make the burner have a short gunshot and make the Coal-water slurry can be fired …\n2019-10-24 · The coal-water slurry fuel was transported through a pipeline to Novosibirskaya TEC-5, Novosibirsk, a distance of 262 km (163 mi). The pipeline had three intermediate pumping stations. The Belovo Novosibirsk project used coal-water slurry fuel in steam boilers at a rate of 1340 tonnes per hour.\n2019-12-1 · Feature of Pulverized Coal Fired Hot Water Boilers. Based on the advanced pulverized coal fired technology, include the technology of pulverized coal feed, storage, transportation, combustion, ignition, flue gas cleaning, automatic control. Bidragon company provide a whole set of new type industrial boiler technology for customer.\nGas Fired Hot Water Boiler Prices - hotelanand.co.in. coal fired steam coal water mixture boilers. coal fuel steam boiler – Industrial Boiler. 2018-3-4 · Coal Water Slurry Fuel(CWSF) Steam Boilers-Automization Type Description of Coal Water Slurry Steam Boilers Coal water slurry fuel (CWSF or CWS or CWF) is a fuel which consists of fine coal particles suspended in water.resence of water in\n2013-11-4 · What is CWM . Coal Water Mixture (CWM) is an advanced method to increase the coal’s economical values. CWM is a combination of coal, water, and additive substances mixture. CWM is a fuel mixture of pulverized coal and water with the help of additives forming a homogeneous viscous suspension during storage, transportation and combustion.\ncoal water slurry boiler - fsyta.org. slurry fired steam boiler zg boiler . Pulverized coal-fired boiler Wikipedia. 2018-7-17 · A pulverized coal-fired boiler is an industrial or utility boiler that generates thermal energy by burning pulverized coal (also known as powdered coal or coal dust since it is as fine as\nCoal Water Slurry boiler - cn-gte.com. 2018-9-24 · Coal water slurry boiler uses coal water slurry as fuel. Coal water slurry is a kind of liquid which is mixed by 70% coal powder, 30% water and a little chemical. It can be pumped, atomized and stored like oil, and also be burned in boiler and furnace. Get a Quote\nslurry fired steam boiler - forestwoodfiredpizza.com.au. coal water slurry cws fired steam boiler – Traveling Grate . Steam boiler is used for heating, gelatinization, and saccharify, etc. Heating equipment is equipped under mash kettle, and then steam produced by coal water slurry cws fired steam boiler enter into the heating equipment, and then heat the raw materials for starch hydrolysis.\nChina Single Drum Industrial Hot Water Steam Boiler with CoalWater Slurry Fired, Find details about China Coal Water Mixture, Industrial Boiler from Single Coal information 2010: with 2009 data Processes in the People's Republic of China Coal water mixture (CWM) is a at least in part, by high preparation costs of the CWM and boiler de\nCoal-water slurry fuel - Wikipedia. 2018-11-30 · Coal-water slurry fuel is a combustible mixture of fine coal particles suspended in water. It can be used to power boilers, gas turbines, diesel engines and heating and power stations. View More; Kingston Fossil Plant coal fly ash slurry spill - Wikipedia\n2018-9-24 · Coal water slurry boiler uses coal water slurry as fuel. Coal water slurry is a kind of liquid which is mixed by 70% coal powder, 30% water and a little chemical. It can be pumped, atomized and stored like oil, and also be burned in boiler and furnace.\n2018-3-4 · The boiler vessel is a three-pass fire Types Of Coal Fired Steam Boiler In ZG – Zhengzhou Boiler CO.,LTD May 13, 2016 ZG Boiler company, as a leading industrial boiler manufacturer in China and global market, provide different types of industrial boiler for customer all over the world.\nHurst Boiler & Welding Company, Inc. has been manufacturing, designing, engineering and servicing gas, oil, coal, solid waste, wood, biomass and hybrid fuel-fired steam and hot water boilers since 1967, for thousands of satisfied customers.In addition to a complete line of steam and hot water boilers, Hurst Boiler & Welding Company also\n2018-4-28 · USE OF COAL WATER SLURRY TO POWER STEAM GENERATOR To construct and operate a high pressure 8 MW steam generating plant specially designed for the combustion of coal water slurry (CWS) derived from the low grade Coal Water Slurry (“CWS”) Fuel: Alternative Fuel for White Papers Coal Water Slurry (“CWS”) Fuel: Alternative Fuel for Thailand.\ncoal slurry fired boiler - karudec.org. Coal-water slurry fuel - Wikipedia. Coal-water slurry fuel is a combustible mixture of fine coal particles suspended in water. It can be used to power boilers, gas turbines, diesel engines and heating Coal-water slurry fuel is fire-proof and explosion-proof. Get a Quote\nCoal Water Slurry 1. CARBON SLURRY FUELEquipment and Ser vices Heat and steam for industrial enterprises Recycling of pyrocarbon / carbon Effective Energy Technologies GmbH Production and supply of equipment Implementation and Engineering Services Liquid Carbon Fuel +43 664 890 4502, +43 660 353 4735 [email protected] www.cwstech.at For public utility companies Recycling of …\nCoal-Fired Boiler - an overview ScienceDirect Topics. Coal-fired boilers are mainly operated at either subcritical or supercritical conditions. From a thermo-physics perspective, two phase mixtures of water and steam are replaced by a single supercritical fluid when the boiler pressure increases above the critical pressure of 22.12 MPa and the corresponding saturation temperature of 374 °C\nLignin can reduce the viscosity of coal-water mixture, giving it good liquidity as the slurry dispersant in the coal industry. This feature effectively reduces the condensation between the grains of coal-water slurry, improving the combustion efficiency. Lignin also can be used as dye dispersion agents and tanning agents in light industry.\n2019-9-26 · A pulverized coal-fired boiler is an industrial or utility boiler that generates thermal energy by burning pulverized coal (also known as powdered coal or coal dust since it is as fine as face powder in cosmetic makeup) that is blown into the firebox.. The basic idea of a firing system using pulverised fuel is to use the whole volume of the furnace for the combustion of solid fuels.\nCoal Water Mixture Boiler - grundschule-orlamuende.de. coal water mixture boiler Boiler Biomass Steam . coal water mixture boiler for sale supply hot water Heat Pump Swimming Pool Heaters Department of Energy For an outdoor swimming pool, use the following tables to help estimate your annual heat pump pool heater costs Author: CharlesNew Type Cwm Coal Water Mixture Fired Boiler.\nChina New Type Cwm Coal Water Mixture Fired Boiler, Find details about China Coal Water Fuel, Steam Generator from New Type Cwm Coal Water Mixture Fired Boiler - Qingdao Enneng Motor Co., Ltd.\nA coal-fired water-steam steam boiler whose fuel is a coal-water slurry is a mixture of 30%-40% water and 60%-70% coal, and then an appropriate amount of dispersant is added, wherein the coal is used The energy that is produced is used to disperse the coal particles to give them good fluidity.", "domain": "chemistry", "round": 3} +{"url": "https://shriekyblog.com/2023/07/12/choose-clay-fields-hort-for-all-soil-remediation-needs/", "date": "2023-09-28T14:00:05Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233510412.43/warc/CC-MAIN-20230928130936-20230928160936-00591.warc.gz", "language_score": 0.9338322281837463, "token_count": 264, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__255632145", "lang": "en", "text": "Soil remediation is the process of removing pollutants and contaminants from soil through a variety of physical, chemical, and biological techniques. Depending on the type and extent of contamination, different remediation methods may be required. Some common types of soil contaminants include heavy metals, pesticides, petroleum products, and asbestos.\nAt Clay Fields Hort, we use a combination of techniques such as soil washing, bioremediation, and stabilisation to remove contaminants and restore your soil’s health.\nSoil contamination can come from many sources, such as industrial activities, agriculture, and household waste. Contaminated soil can lead to plant growth problems, soil erosion, and water pollution. With soil remediation, you can eliminate the potential risks of soil contamination and ensure the health and safety of your garden, environment, and loved ones.\nChoosing Clay Fields Hort for your soil remediation needs comes with many benefits. Our services are environmentally friendly, safe, and cost-effective. We use sustainable and natural techniques whenever possible, minimising the use of harmful chemicals and reducing the risk of environmental damage.\nOur team consists of experts who are passionate and dedicated to providing you with the best soil advisor Melbourne possible. With us, you can expect prompt, efficient, and reliable services that meet your expectations and exceed them.", "domain": "chemistry", "round": 3} +{"url": "https://www.ionbeamcenters.eu/RADIATE-project-partners/ist/", "date": "2023-06-01T01:19:44Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-23/segments/1685224647525.11/warc/CC-MAIN-20230601010402-20230601040402-00135.warc.gz", "language_score": 0.8085958957672119, "token_count": 355, "dump": "CC-MAIN-2023-23", "global_id": "webtext-fineweb__CC-MAIN-2023-23__0__225649814", "lang": "en", "text": "The Ion Beam Laboratory (IBL) is part of Laboratório de Aceleradores e Tecnologias de Radiação (LATR), a Research and Development Laboratory of Instituto Superior Técnico (IST) of University of Lisbon.\nThe accelerator group is focused in the development of fundamental and applied research using ion beams. The IBL comprises a 2.5 MV Van de Graaff accelerator, a 3 MV tandem accelerator, a 210 kV ion implanter, and a nuclear microprobe equipped with multiple experimental chambers to support a wide scope of activities in scientific domains as varied as materials characterization and modification, nanotechnology, health, biomedicine, environmental sciences, and cultural heritage.\nBesides the conventional ion beam techniques, IBL offers the possibility to measure in-situ and simultaneously Ion Beam Induced Charge (IBIC) and Ion Beam Induced Luminescence (IBIL). In addition an Accelerator Mass Spectrometry (AMS) system with a microbeam allows isotope depth profile.\nIST’s main areas of competence:\n- ion implantation\n- multidisciplinary research center: materials science, nanotechnology, health, bio medicine, environmental sciences, cultural heritage\nRole in RADIATE:\n- Work package leader: “Common Standards and Data Management”\n- Task leader: “Training the Next Generation”\n- Contribution to joint research activities\n- Task leader: “Multiparameter Data Filtering and Analysis” IST’s role will be the development and application of a data interpretation software for ion beam analysis", "domain": "chemistry", "round": 3} +{"url": "https://outbax.com.au/camping/batteries-galore", "date": "2023-12-08T15:58:46Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100762.64/warc/CC-MAIN-20231208144732-20231208174732-00531.warc.gz", "language_score": 0.9498761296272278, "token_count": 872, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__41445956", "lang": "en", "text": "Here at Outbax, we have batteries galore for every need. Batteries play a hand in the overall running costs of appliances, but in order to keep expenses down, you'll need to pick the right batteries for the job. There are two popular AA and AAA battery types: those that need to be disposed of after a single use, and those that can be recharged.\nHow do rechargeable batteries work?\nRechargeable AA and AAA batteries are a must for high-powered devices, like digital radios, DSLR camera accessories and remote-control cars, where a day of heavy use will suck the juice out of them. You'll need to factor in the cost of a charger, but after a dozen or so uses, rechargeable batteries more than pay for themselves.\nModern rechargeable batteries have a chemical makeup of nickel-metal hydride (NiMH). These batteries allow for a larger capacity that can hold more power for longer, compared to the older batteries based on nickel-cadmium (NiCad).\nThe environmentally conscious consumer should opt for rechargeable batteries, particularly if you have high-use demands. Unlike single-use batteries, which are destined to be disposed of once they run flat, rechargeable batteries can be reused several hundred times.\nHowever, the eventual disposal of rechargeable batteries can be an issue as they're more toxic than most single-use batteries, so when it's time to retire your rechargeable batteries, sites such as cleanup.org.au can provide valuable advice on your nearest recycling centre.\nLow self-discharge batteries\nRechargeable batteries lose some power every day, even when not being used, in a process known as self-discharging. If you plan on using rechargeable batteries in devices that aren't used often, then it's best to purchase a low self-discharge (LSD) battery. These batteries hold onto charge for a longer period of time when they aren't being used – the latest LSD batteries claim to retain up to 85% of their charge after 12 months of non-use, whereas standard NiMH batteries may lose 50% of their charge.\nThe ability to immediately use the batteries out of the packet is another handy feature of an LSD or 'ready to use' NiMH battery, particularly if you're looking to immediately power up the latest birthday or Christmas present.\nHow do disposable batteries work?\nDisposable batteries, also known as single-use batteries, are designed to be used until they have no power left. If you depend on your device to operate straight away after long periods of inactivity, such as an emergency torch, then it's preferable to use a good alkaline single-use battery.\nLithium and alkaline batteries are functionally about the same in nearly all aspects. However, lithium batteries can be used in more powerful devices without having to worry about the battery draining too quickly, as they have a higher capacity, slightly higher initial voltage and a longer shelf life. The downside is lithium batteries are more expensive.\nBreaking down the jargon\nMilliampere hours (mAh): A measurement of the capacity of a battery. The higher the mAh, the longer the battery will last. If your battery is rechargeable then the mAh rating is how long the battery will last per charge.\nMemory effect: Most often associated with NiCad batteries where the battery appears to fail to charge to its full capacity, instead setting itself to show fully charged at the capacity of the battery when placed in the charger.\nClaimed capacity mAh: High-drain tasks such as digital photography with frequent use of the flash may benefit from a battery with a higher capacity.\nLithium-ion single use: These last the longest in high-drain devices, like digital cameras, and might be a good option for a backup when travelling. Manufacturers claim they have a shelf life of around 10 years. There are a few online sites offering rechargeable Li-Ion AA batteries. Most of these batteries have a nominal voltage of 3.7V, which will fry your electronic devices if they take normal AA batteries, so avoid them unless you know exactly what devices you have that can cope with a nominal voltage greater than 1.5V.", "domain": "chemistry", "round": 3} +{"url": "http://www.abcam.com/human-emilin1-protein-fragment-ab116414.html", "date": "2013-12-11T12:44:52Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2013-48/segments/1386164036407/warc/CC-MAIN-20131204133356-00066-ip-10-33-133-15.ec2.internal.warc.gz", "language_score": 0.7773872017860413, "token_count": 547, "dump": "CC-MAIN-2013-48", "global_id": "webtext-fineweb__CC-MAIN-2013-48__0__108644512", "lang": "en", "text": "Human EMILIN1 protein fragment (ab116414)\n- Product nameHuman EMILIN1 protein fragmentSee all EMILIN1 proteins and peptides ...\n- SourceE. coli\n- Amino Acid Sequence\n- Molecular weight39 kDa including tags\n- Amino acids676 to 1016\nOur Abpromise guarantee covers the use of ab116414 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\n- Mass spectrometryMALDI-TOF-TOF\n- Purity> 95\n% by SDS-PAGE.\n- Concentration information loading...\nPreparation and Storage\n- Stability and Storage\nShipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.\nConstituent: 99% PBS\n- Elastin microfibril interface located protein\n- Elastin microfibril interface located protein 1\n- Elastin microfibril interface-located protein 1\n- Elastin microfibril interfacer 1\n- EMILIN 1\n- FunctionMay be responsible for anchoring smooth muscle cells to elastic fibers, and may be involved not only in the formation of the elastic fiber, but also in the processes that regulate vessel assembly. Has cell adhesive capacity.\n- Tissue specificityDistributed in tissues where resilience and elastic recoil are prominent. Highest levels in the adult small intestine, aorta, lung, uterus, and appendix and in the fetal spleen, kidney, lung, and heart; intermediate expression was detected in adult liver, ovary, colon, stomach, lymph node and spleen; adult heart, bladder, prostate, adrenal gland, mammary gland, placenta and kidney showed low expression whereas a series of other adult tissues, including skeletal muscle and different regions of adult brain show no expression.\n- Sequence similaritiesContains 1 C1q domain.\nContains 1 collagen-like domain.\nContains 1 EMI domain.\n- Cellular localizationSecreted > extracellular space > extracellular matrix. Found mainly at the interface between amorphous elastin and microfibrils.\nHuman EMILIN1 protein fragment images\n10% SDS-PAGE stained with Coomassie Blue (Lane 1), immunobloting with anti-6xHis (Lane 2)\nReferences for Human EMILIN1 protein fragment (ab116414)\nab116414 has not yet been referenced specifically in any publications.", "domain": "chemistry", "round": 3} +{"url": "http://ecocyc.org/META/NEW-IMAGE?type=PATHWAY&object=PWY-2761", "date": "2016-05-02T03:41:50Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2016-18/segments/1461860122420.60/warc/CC-MAIN-20160428161522-00065-ip-10-239-7-51.ec2.internal.warc.gz", "language_score": 0.6740114092826843, "token_count": 1976, "dump": "CC-MAIN-2016-18", "global_id": "webtext-fineweb__CC-MAIN-2016-18__0__11856682", "lang": "en", "text": "This view shows enzymes only for those organisms listed below, in the list of taxa known to possess the pathway. If an enzyme name is shown in bold, there is experimental evidence for this enzymatic activity.\n|Superclasses:||Biosynthesis → Secondary Metabolites Biosynthesis → Phenylpropanoid Derivatives Biosynthesis → Flavonoids Biosynthesis → Isoflavonoids Biosynthesis|\n|Biosynthesis → Secondary Metabolites Biosynthesis → Phytoalexins Biosynthesis → Isoflavonoid Phytoalexins Biosynthesis|\nExpected Taxonomic Range: Fabaceae\nGlyceollins are the main phytoalexins found in soybean (Glycine max). Consistent with most of the isoflavonoid derived phytoalexins, glyceollins are induced in response to plant pathogens [Boue00] [Hagmann84] and related stress [Landini03].\nThe initial enzymatic steps of the glyceollin biosynthesis parallel the biosynthesis of medicarpin and maackiain. In contrast to those simple pterocarpans the complex prenylated pterocarpans (phaseollin, glyceollin) also derive from the 5-deoxyisoflavone daidzein but do not involve a methoxylation step during their biosynthesis.\nGlycinol, the final compound in this part of the glyceollin pathway, is stereospecifically hydroxylated at the 6a position resulting in the (-) or (6aS,11aS)-3,6a,9-configuration of this compound [Hagmann84]. The remaining enzymatic reactions maintain the given configuration as demonstrated for other pathways that involve a pterocarpan-6a-hydroxylase in their biosynthesis (e.g. pisatin) [Kochs89].\nSuperpathways: superpathway of pterocarpan biosynthesis (via daidzein)\nHagmann84: Hagmann ML, Heller W, Grisebach H (1984). \"Induction of phytoalexin synthesis in soybean. Stereospecific 3,9-dihydroxypterocarpan 6a-hydroxylase from elicitor-induced soybean cell cultures.\" Eur J Biochem 142(1);127-31. PMID: 6540173\nKochs89: Kochs G, Grisebach H (1989). \"Phytoalexin synthesis in soybean: purification and reconstitution of cytochrome P450 3,9-dihydroxypterocarpan 6a-hydroxylase and separation from cytochrome P450 cinnamate 4-hydroxylase.\" Arch Biochem Biophys 273(2);543-53. PMID: 2505672\nAkashi98: Akashi T, Aoki T, Ayabe S (1998). \"CYP81E1, a cytochrome P450 cDNA of licorice (Glycyrrhiza echinata L.), encodes isoflavone 2'-hydroxylase.\" Biochem Biophys Res Commun 251(1);67-70. PMID: 9790908\nBless88: Bless W, Barz W, (1988) \"Isolation of pterocarpan synthase, the terminal enzyme of pterocarpan phytoalexin biosynthesis in cell suspension cultures of Cicer arietinum.\" FEBS Letters (1988), 235(1), 47-50.\nEbel86: Ebel J, Grisebach H, Bonhoff A, Grab D, Hoffmann C, Kochs G, Mieth H, Schmidt W, Staeb M, (1986) \"Phytoalexin synthesis in soybean following infection of roots with Phytophtora megasperma or treatment of cell cultures with fungal elicitors.\" In: Lugtenberg, B. (editor) Regocnition in microbe-plant symbiotic and pathogenic interactions (1986), NATO ASI series, series H: cell biology, Vol. 4, 345-361, Springer-Verlag Berlin Heidelberg New York London Paris Tokyo.\nFischer90: Fischer D, Ebenau-Jehle C, Grisebach H, (1990) \"Purification and characterization of pterocarpan synthase from elicitor-challenged soybean cell cultures.\" Phytochemistry (1990), 29(9), 2879-2882.\nFischer90a: Fischer D, Ebenau-Jehle C, Grisebach H (1990). \"Phytoalexin synthesis in soybean: purification and characterization of NADPH:2'-hydroxydaidzein oxidoreductase from elicitor-challenged soybean cell cultures.\" Arch Biochem Biophys 276(2);390-5. PMID: 2306102\nGunia: Gunia W, Hinderer W, Wittkampf U, Barz W, (1991) \"Elicitor induction of cytochrome P-450 monooxygenases in cell suspension cultures of chickpea (Cicer arietinum L.) and their involvement in pterocarpan phytoalexin biosynthesis.\" Z. Naturforsch. 46c, 58-66.\nGuo94: Guo L, Dixon RA, Paiva NL (1994). \"The 'pterocarpan synthase' of alfalfa: association and co-induction of vestitone reductase and 7,2'-dihydroxy-4'-methoxy-isoflavanol (DMI) dehydratase, the two final enzymes in medicarpin biosynthesis.\" FEBS Lett 356(2-3);221-5. PMID: 7805842\nGuo94a: Guo L, Dixon RA, Paiva NL (1994). \"Conversion of vestitone to medicarpin in alfalfa (Medicago sativa L.) is catalyzed by two independent enzymes. Identification, purification, and characterization of vestitone reductase and 7,2'-dihydroxy-4'-methoxyisoflavanol dehydratase.\" J Biol Chem 269(35);22372-8. PMID: 8071365\nHinderer: Hinderer W, Flentje U, Barz W, (1987) \"Microsomal isoflavone 2'- and 3'-hydroxylases from chickpea (Cicer arietinum L.) cell suspensions induced for pterocarpan phytoalexin formation.\" FEBS Letters, 214(1), 101-106.\nKochs92: Kochs G, Werck-Reichhart D, Grisebach H (1992). \"Further characterization of cytochrome P450 involved in phytoalexin synthesis in soybean: cytochrome P450 cinnamate 4-hydroxylase and 3,9-dihydroxypterocarpan 6a-hydroxylase.\" Arch Biochem Biophys 293(1);187-94. PMID: 1731635\nPaiva91: Paiva NL, Edwards R, Sun YJ, Hrazdina G, Dixon RA (1991). \"Stress responses in alfalfa (Medicago sativa L.) 11. Molecular cloning and expression of alfalfa isoflavone reductase, a key enzyme of isoflavonoid phytoalexin biosynthesis.\" Plant Mol Biol 17(4);653-67. PMID: 1912490\nPaiva94: Paiva NL, Sun Y, Dixon RA, VanEtten HD, Hrazdina G (1994). \"Molecular cloning of isoflavone reductase from pea (Pisum sativum L.): evidence for a 3R-isoflavanone intermediate in (+)-pisatin biosynthesis.\" Arch Biochem Biophys 312(2);501-10. PMID: 8037464\nSchopfer98: Schopfer CR, Kochs G, Lottspeich F, Ebel J (1998). \"Molecular characterization and functional expression of dihydroxypterocarpan 6a-hydroxylase, an enzyme specific for pterocarpanoid phytoalexin biosynthesis in soybean (Glycine max L.).\" FEBS Lett 432(3);182-6. PMID: 9720921\nTiemann91: Tiemann K, Inze D, Van Montagu M, Barz W (1991). \"Pterocarpan phytoalexin biosynthesis in elicitor-challenged chickpea (Cicer arietinum L.) cell cultures. Purification, characterization and cDNA cloning of NADPH:isoflavone oxidoreductase.\" Eur J Biochem 200(3);751-7. PMID: 1915347\n©2016 SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025-3493", "domain": "chemistry", "round": 3} +{"url": "https://www.mdpi.com/2072-6651/11/7/403", "date": "2019-07-24T04:36:07Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-30/segments/1563195530385.82/warc/CC-MAIN-20190724041048-20190724063048-00068.warc.gz", "language_score": 0.9032567739486694, "token_count": 611, "dump": "CC-MAIN-2019-30", "global_id": "webtext-fineweb__CC-MAIN-2019-30__0__102764941", "lang": "en", "text": "Prodigiosin Promotes Nrf2 Activation to Inhibit Oxidative Stress Induced by Microcystin-LR in HepG2 Cells\nAbstractMicrocystin-LR (MC-LR), a cyanotoxin produced by cyanobacteria, induces oxidative stress in various types of cells. Prodigiosin, a red linear tripyrrole pigment, has been recently reported to have antimicrobial, antioxidative, and anticancer properties. How prodigiosin reacts to reactive oxygen species (ROS) induced by MC-LR is still undetermined. This study aimed to examine the effect of prodigiosin against oxidative stress induced by MC-LR in HepG2 cells. Ros was generated after cells were treated with MC-LR and was significantly inhibited with treatment of prodigiosin. In prodigiosin-treated cells, the levels of nuclear factor erythroid 2-related factor 2 (Nrf2) and Nrf2-related phase II enzyme heme oxygenase-1 (HO-1) were increased. Besides, prodigiosin contributed to enhance nuclear Nrf2 level and repressed ubiquitination. Furthermore, prodigiosin promoted Nrf2 protein level and inhibited ROS in Nrf2 knocked down HepG2 cells. Results indicated that prodigiosin reduced ROS induced by MC-LR by enhancing Nrf2 translocation into the nucleus in HepG2 cells. The finding presents new clues for the potential clinical applications of prodigiosin for inhibiting MC-LR-induced oxidative injury in the future. View Full-Text\nShare & Cite This Article\nChen, J.; Li, Y.; Liu, F.; Hou, D.-X.; Xu, J.; Zhao, X.; Yang, F.; Feng, X. Prodigiosin Promotes Nrf2 Activation to Inhibit Oxidative Stress Induced by Microcystin-LR in HepG2 Cells. Toxins 2019, 11, 403.\nChen J, Li Y, Liu F, Hou D-X, Xu J, Zhao X, Yang F, Feng X. Prodigiosin Promotes Nrf2 Activation to Inhibit Oxidative Stress Induced by Microcystin-LR in HepG2 Cells. Toxins. 2019; 11(7):403.Chicago/Turabian Style\nChen, Jihua; Li, Yuji; Liu, Fuqiang; Hou, De-Xing; Xu, Jingjing; Zhao, Xinying; Yang, Fei; Feng, Xiangling. 2019. \"Prodigiosin Promotes Nrf2 Activation to Inhibit Oxidative Stress Induced by Microcystin-LR in HepG2 Cells.\" Toxins 11, no. 7: 403.\nNote that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.", "domain": "chemistry", "round": 3} +{"url": "https://ph02.tci-thaijo.org/index.php/ijast/article/view/247656", "date": "2023-12-03T20:03:00Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100508.53/warc/CC-MAIN-20231203193127-20231203223127-00009.warc.gz", "language_score": 0.731459379196167, "token_count": 3347, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__13412258", "lang": "en", "text": "Main Article Content\nOil palm nanocellulose has been demonstrated to display a wide range of unique properties for many fields. They are suitable for biomedical applications and have been used in this domain for decades. The current variety of nanocellulose fibers allows the development of new nanocomposites. This work fabricated oil palm nanocellulose with variations of fiber loading (1, 2, 3, 4, and 5 wt%) and thermoplastic polyurethane (TPU) polymer matrix by using a mechanical stirring followed by hot pressing methods. The physical characters of nanocellulose oil palm reinforced TPU nanocomposites, such as water absorption, thickness swelling, and density were characterized. The fiber loading of oil palm nanocellulose content at 5 wt% shows the highest water uptake, thickness swelling, and the lowest density properties of oil palm nanocellulose reinforced TPU nanocomposites.\nL. Lamanna, F. Rizzi, V. R. Bhethanabotla, and M. D. Vittorio, “Conformable surface acoustic wave biosensor for E-coli fabricated on PEN plastic film,” Biosensors and Bioelectronics, vol. 163, p. 112164, 2020.\nS. Kumari, S. Mohapatra, and R. S. Moirangthem, “Development of flexible plasmonic plastic sensor using nanograting textured laminating film,” Materials Research Express, vol. 4, no. 2, p. 25008, 2017.\nK. Park, P. Tran, N. Deaton, and J. P. Desai, “Multi-walled carbon nanotube (MWCNT)/ PDMS-based flexible sensor for medical applications,” in 2019 International Symposium on Medical Robotics (ISMR), 2019, pp. 1–8.\nQ. Xue, Z. Li, Q. Wang, W. Pan, Y. Chang, and X. Duan, “Nanostrip flexible microwave enzymatic biosensor for noninvasive epidermal glucose sensing,” Nanoscale Horizons, vol. 5, no. 6, pp. 934–943, 2020.\nP. K. Singh and A. Singal, “Reducing the hygroscopic swelling in MEMS sensor using different mold materials,” International Journal of Electrical and Computer Engineering, vol. 10, no.1, pp. 494–499, 2020.\nT. Someya, Z. Bao, and G. G. Malliaras, “The rise of plastic bioelectronics,” Nature, vol. 540, no. 7633, pp. 379–385, 2016. D. Huang, F. Liao, S. Molesa, D. Redinger, and V. Subramanian, “Plastic-compatible low resistance printable gold nanoparticle conductors for flexible electronics,” Journal of The Electrochemical Society, vol. 150, no. 7, p. G412, 2003.\nM. Rasheed, M. Jawaid, B. Parveez, A. Zuriyati, and A. Khan, “Morphological, chemical and thermal analysis of cellulose nanocrystals extracted from bamboo fibre,” International Journal of Biological Macromolecules, vol. 160, pp. 183–191, 2020.\nM. D. Alotabi, B. A. Alshammari, N. Saba, O. Y. Alothman, L. K. Kian, A. Khan, and M. Jawaid, “Microcrystalline cellulose from fruit bunch stalk of date palm: Isolation and characterization,” Journal of Polymers and the Environment, vol. 28, no. 6, pp. 1766–1775, 2020.\nA. Khan, M. Jawaid, L. K. Kian, A. A. P. Khan, and A. M. Asiri, “Isolation and production of nanocrystalline cellulose from conocarpus fiber,” Polymers (Basel), vol. 13, no. 11, p. 1835, 2021.\nA. Khan, A. M. Asiri, M. Jawaid, and N. Saba, “Effect of cellulose nano fibers and nano clays on the mechanical, morphological, thermal and dynamic mechanical performance of kenaf/epoxy composites,” Carbohydrate Polymers, vol. 239, p. 116248, 2020.\nM. Asad, N. Saba, A. M. Asiri, M. Jawaid, E. Indarti, and W. D. Wanrosli, “Preparation and characterization of nanocomposite films from oil palm pulp nanocellulose/poly (vinyl alcohol) by casting method,” Carbohydrate Polymers, vol. 191, pp. 103–111, 2018.\nC. F. Mok, Y. C. Ching, F. Muhamad, N. A. Abu Osman, and R. Singh, “Poly(vinyl alcohol)- α-chitin composites reinforced by oil palm empty fruit bunch fiber-derived nanocellulose,” International Journal of Polymer Analysis and Characterization, vol. 22, no. 4, pp. 294–304, 2017.\nY. C. Ching, A. Rahman, K. Y. Ching, N. L. Sukiman, and H. C. Cheng, “Preparation and characterization of polyvinyl alcohol-based composite reinforced with nanocellulose and nanosilica,” BioResources, vol. 10, no. 2, pp. 3364–3377, 2015.\nN. A. Nasimudeen, S. Karounamourthy, J. Selvarathinam, S. M. K. Thiagamani, H. Pulikkalparambil, S. Krishnasamy, and C. Muthukumar, “Mechanical, absorption and swelling properties of vinyl ester based natural fibre hybrid composites,” Applied Science and Engineering Progress, vol. 14, no. 4, pp. 680– 688, 2021, doi: 10.14416/j.asep.2021.08.006.\nM. E. Hoque, A. M. Rayhan, and S. I. Shaily, “Natural fiber-based green composites: Processing, properties and biomedical applications,” Applied Science and Engineering Progress, vol. 14, no. 4, pp. 689–718, 2021, doi: 10.14416/j.asep. 2021.09.005.\nN. Lisdayana, F. Fahma, T. C. Sunarti, and E. S. Iriani, “Thermoplastic starch–PVA nanocomposite films reinforced with nanocellulose from oil palm empty fruit bunches (OPEFBs): Effect of starch type,” Journal of Natural Fibers, vol. 17, no. 7, pp. 1069–1080, 2020.\nM. Khalifa, S. Anandhan, G. Wuzella, H. Lammer, and A. R. Mahendran, “Thermoplastic polyurethane composites reinforced with renewable and sustainable fillers–a review,” Polymer-Plastics Technology and Materials, vol. 59, no. 16, pp. 1751–1769, 2020.\nA. Atiqah, M. Jawaid, S. M. Sapuan, M. R. Ishak, M. N. M. Ansari, and R. A. Ilyas, “Physical and thermal properties of treated sugar palm/glass fibre reinforced thermoplastic polyurethane hybrid composites,” Journal of Materials Research and Technology, vol. 8, no. 5, pp. 3726–3732, Sep. 2019, doi: 10.1016/j.jmrt.2019.06.032.\nM. R. Amri, C. T. Guan, S. S. Osman Al-Edrus, F. M. Yasin, and S. F. Mohamad, “Effect of cellulose nanofibrils on the properties of jatropha oilbasedwaterborne polyurethane nanocomposite film,” Polymers (Basel), vol. 13, no. 9, 2021, doi: 10.3390/polym13091460.\nK. Kępa, N. Amiralian, D. J. Martin, and L. Grøndahl, “Grafting from cellulose nanofibres with naturally-derived oil to reduce water absorption,” Polymer (Guildf), vol. 222, 2021, doi: 10.1016/j. polymer.2021.123659.\nE. Ogunsona, S. Hojabr, R. Berry, and T. H. Mekonnen, “Nanocellulose-triggered structural and property changes of acrylonitrile-butadiene rubber films,” International Journal of Biological Macromolecules, vol. 164, pp. 2038–2050, 2020, doi: 10.1016/j.ijbiomac.2020.07.202.\nA. G. de Souza, G. F. de Lima, V. K. Rangari, and D. dos Santos Rosa, “Investigation of surfacepegylated nanocellulose as reinforcing agent on PBAT biodegradable nanocomposites,” Polymer Composites, vol. 41, no. 10, pp. 4340–4352, 2020, doi: 10.1002/pc.25716.\nK. D. H. N. Kahavita, A. M. P. B. Samarasekara, D. A. S. Amarasinghe, and L. Karunanayake, “Nanofibrillated cellulose reinforced polypropylene composites: Influence of silane (SI-69) surface modification,” Cellulose Chemistry and Technology, vol. 54, no. 7–8, pp. 789–797, 2020, doi: 10.35812/CelluloseChemTechnol.2020.54.78.\nT. B. Shalom, Y. Nevo, D. Leibler, Z. Shtein, C. Azerraf, S. Lapidot, and O. Shoseyov, “Cellulose nanocrystals (CNCs) induced crystallization of Polyvinyl Alcohol (PVA) super performing nanocomposite films,” Macromolecular Bioscience, vol. 19, no. 3, p. e1800347, 2019, doi: 10.1002/ mabi.201800347.\nP. Zhang, Y.-Y. He, D. Gao, Y. Cai, and B. Liu, “Hydrolytic and thermal degradation of polyethylene glycol compatibilized poly(lactic acid)-nanocrystalline cellulose bionanocomposites,” Journal of Applied Polymer Science, vol. 136, no. 2, 2019, doi: 10.1002/app.46933.\nE. Espinosa, D. Filgueira, A. Rodríguez, and G. Chinga-Carrasco, “Nanocellulose-based inks— effect of alginate content on the water absorption of 3D printed constructs,” Bioengineering, vol. 6, no. 3, p. 65, 2019.\nA. A. Septevani, A. Rifathin, A. A. Sari, Y. Sampora, G. N. Ariani, and D. Sondari, “Oil palm empty fruit bunch-based nanocellulose as a super-adsorbent for water remediation,” Carbohydrate Polymers, vol. 229, p. 115433, 2020.\nH. Mohit and V. A. M. Selvan, “Effect of a novel chemical treatment on the physico-thermal properties of sugarcane nanocellulose fiber reinforced epoxy nanocomposites,” International Polymer Processing, vol. 35, no. 2, pp. 211–220, 2020, doi: 10.3139/217.3855.\nT. S. Franco, R. M. J. Amezcua, A. V. Rodrìguez, S. G. Enriquez, M. R. Urquíza, E. M. Mijares, and G. Bolzon de Muniz, “Carboxymethyl and nanofibrillated cellulose as additives on the preparation of chitosan biocomposites: Their influence over films characteristics,” Journal of Polymers and the Environment, vol. 28, no. 2, pp. 676–688, 2020, doi: 10.1007/s10924-019- 01639-0.\nR. A. Ilyas, S. M. Sapuan, A. Atiqah, R. Ibrahim, H. Abral, M. R. Ishak, E. S. Zainudin, N. M. Nurazzi, M. S. N. Atikah, M. N. M. Ansari, M. R. M. Asyraf, A. B. M. Supian, and H. Ya, “Sugar palm (Arenga pinnata [Wurmb.] Merr) starch films containing sugar palm nanofibrillated cellulose as reinforcement: Water barrier properties,” Polymer Composites, vol. 41, no. 2, pp. 459–467, 2020.\nP. Zhang, Y. Lu, M. Fan, P. Jiang, and Y. Dong, “Modified cellulose nanocrystals enhancement to mechanical properties and water resistance of vegetable oil-based waterborne polyurethane,” Journal of Applied Polymer Science, vol. 136, no. 47, 2019, doi: 10.1002/app.48228.\nR. Syafiq, S. M. Sapuan, and M. R. M. Zuhri, “Antimicrobial activity, physical, mechanical and barrier properties of sugar palm based nanocellulose/ starch biocomposite films incorporated with cinnamon essential oil,” Journal of Materials Research and Technology, vol. 11, pp. 144–157, 2021.\nA. Atiqah, M. Jawaid, M. R. Ishak, and S. M. Sapuan, “Moisture absorption and thickness swelling behaviour of sugar palm fibre reinforced thermoplastic polyurethane,” Procedia Engineering, vol. 184, pp. 581–586, 2017, doi: 10.1016/j. proeng.2017.04.142.\nA. Atiqah, M. Jawaid, S. M. Sapuan, and M. R. Ishak, “Physical properties of silane-treated sugar palm fiber reinforced thermoplastic polyurethane composites,” in IOP Conference Series: Materials Science and Engineering, Jun. 2018, vol. 368, no. 1, doi: 10.1088/1757-899X/368/1/012047.", "domain": "chemistry", "round": 3} +{"url": "https://mirnainhibitor.com/the-results-showed-that-i-all-the-complexes-formed-were-stable", "date": "2020-09-21T09:11:47Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-40/segments/1600400201601.26/warc/CC-MAIN-20200921081428-20200921111428-00011.warc.gz", "language_score": 0.9342212677001953, "token_count": 766, "dump": "CC-MAIN-2020-40", "global_id": "webtext-fineweb__CC-MAIN-2020-40__0__139688710", "lang": "en", "text": "The results showed that (i) all the complexes formed were stable and did not dissociate during electrophoresis, (ii) the presence of the [4Fe-4S]2+ cluster increased Fnr-binding affinity to fnr and nhe promoter regions and did not affect Fnr-binding to hbl promoter regions. Regarding the nhe promoter, the observed difference in apparent binding affinity between the apo- and holo- forms was narrow (≤ 1.3). Also, a fairly high level of Fnr (more than 0.6 μM) was needed to form the\nDNA-Fnr complex. These data suggest that holo- and apoFnr have similar affinities for the nhe promoter. learn more Figure 4 Binding of apo- and holoFnr to promoter regions of fnr , hbl and nhe genes determined by EMSA. DNA probes www.selleckchem.com/ATM.html corresponding to fnr (A), nhe (B), hbl1\n(C), hbl2 (D) and a negative control (E) were bound with increasing concentrations of apoFnr (−) and holoFnr (+) as indicated. The results are representative of triplicate experiments. Fnr forms a ternary complex with ResD and PlcR To determine whether Fnr could interact in vitro with PlcR and ResD, two other regulators 17DMAG of nhe and hbl, Far-Western analyses were conducted under anoxic conditions using the apo- and holo- forms of Fnr. Figure 5 shows that (i) BSA (negative control) did not bind to PlcR or ResD, while PlcR and ResD showed self-binding consistent with their capacity to oligomerize [11, 12], (ii) both apo- and holoFnr interact with PlcR and ResD and (iii) PlcR interacts with ResD. These pairwise interactions were confirmed by cross-linking experiments using dimethyl suberimidate (Additional file 2). Figure 5 Far-Western analysis of PlcR-Fnr, PlcR-ResD and ResD-Fnr interactions. Increased amounts of purified Fnr, ResD and PlcR\nwere spotted onto nitrocellulose membranes and incubated Carnitine palmitoyltransferase II with biotinylated-PlcR (A) or biotinylated-ResD (B), under anoxic conditions. PlcR and ResD binding was detected using streptavidin-HRP complex and visualized by chemiluminescence. BSA was used as negative control. To determine whether Fnr could interact in vivo with PlcR and ResD, soluble protein extracts were prepared from anaerobically-grown B. cereus cells and incubated with anti-Fnr antibodies. Figure 6A shows that anti-Fnr antibodies could co-precipitate ResD and PlcR independently. Interestingly, Figure 6B shows that anti-Fnr antibodies co-immunoprecipitated ResD, PlcR and Fnr. These results strongly suggest that Fnr, ResD and PlcR form a ternary complex in vivo. Figure 6 Western blot analysis of proteins from B. cereus crude extract immunoprecipitated with immobilized Fnr-specific antibodies. (A) Proteins resulting from an anti-Fnr pull-down were analyzed by Western blotting with anti-Fnr (A1), anti-ResD (A2) or anti- PlcR (A3) antibodies.", "domain": "chemistry", "round": 3} +{"url": "https://www.rndsystems.com/products/human-timp-2-antibody-89025_mab971", "date": "2016-10-24T22:03:34Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2016-44/segments/1476988719784.62/warc/CC-MAIN-20161020183839-00173-ip-10-171-6-4.ec2.internal.warc.gz", "language_score": 0.875618577003479, "token_count": 754, "dump": "CC-MAIN-2016-44", "global_id": "webtext-fineweb__CC-MAIN-2016-44__0__88847165", "lang": "en", "text": "Detection of Human TIMP‑2 by Western Blot. Western blot shows Recombinant Human TIMP-2 Western Blot Standard Protein (Catalog # WBC023) and lysates of HeLa human cervical epithelial carcinoma cell line and human placenta tissue. PVDF membrane was probed with 2 µg/mL of Mouse Anti-Human TIMP‑2 Monoclonal Antibody (Catalog # MAB971) followed by HRP-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # HAF018). A specific band was detected for TIMP‑2 at approximately 22 kDa (as indicated).This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.\nTIMP‑2 in Human Ovarian Cancer Tissue. TIMP‑2 was detected in immersion fixed paraffin-embedded sections of human ovarian cancer tissue using 15 µg/mL Mouse Anti-Human TIMP‑2 Monoclonal Antibody (Catalog # MAB971) overnight at 4 °C. Tissue was stained with the Anti-Mouse HRP-AEC Cell & Tissue Staining Kit (red; Catalog # CTS003) and counterstained with hematoxylin (blue). View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.\nPreparation and Storage\nReconstitute at 0.5 mg/mL in sterile PBS.\nThe product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C\nStability & Storage\nUse a manual defrost freezer and avoid repeated freeze-thaw cycles.\n12 months from date of receipt, -20 to -70 °C as supplied.\n1 month, 2 to 8 °C under sterile conditions after reconstitution.\n6 months, -20 to -70 °C under sterile conditions after reconstitution.\nTissue inhibitors of metalloproteinases or TIMPs are a family of proteins that regulate the activation and proteolytic activity of the zinc enzymes known as matrix metalloproteinases (MMPs). There are four members of the family, TIMP-1, TIMP-2, TIMP-3, and TIMP-4. TIMP-2 is a non N-glycosylated protein with a molecular mass of 22 kDa produced by a wide range of cell types, which inhibits MMPs non-covalently by the formation of binary complexes. TIMP-2 also has erythroid-potentiating and cell growth promoting activities.\nTissue Inhibitors of Metalloproteinases 2\nEntrez Gene IDs:\n7077 (Human); 21858 (Mouse); 29543 (Rat)\nCSC-21Ktissue inhibitor of metalloproteinase 2; metalloproteinase inhibitor 2; TIMP metallopeptidase inhibitor 2; TIMP2; TIMP-2; Tissue inhibitor of metalloproteinases 2\nR&D Systems personnel manually curate a database that contains references using R&D Systems products.\nThe data collected includes not only links to publications in PubMed,\nbut also provides information about sample types, species, and experimental conditions.\nThe reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.", "domain": "chemistry", "round": 3} +{"url": "https://gluethings.com/will-wd-40-remove-gorilla-glue/", "date": "2023-05-29T14:40:04Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-23/segments/1685224644867.89/warc/CC-MAIN-20230529141542-20230529171542-00288.warc.gz", "language_score": 0.9283233284950256, "token_count": 2769, "dump": "CC-MAIN-2023-23", "global_id": "webtext-fineweb__CC-MAIN-2023-23__0__141254708", "lang": "en", "text": "Have you ever found yourself in a sticky situation, quite literally, where Gorilla Glue has stubbornly adhered to a surface? Despite your best efforts, scraping and using harsh chemicals have failed to remove it. If this sounds familiar, then you’re in luck because we’re about to explore a potential solution: WD-40.\nWD-40 is the multi-use product that’s earned its reputation as a miracle worker. But can it handle Gorilla Glue? In this blog post, we’ll delve into the science behind both products to provide a definitive answer.\nFirstly, we’ll examine what makes Gorilla Glue so notoriously difficult to remove. Then we’ll take a closer look at WD-40’s ingredients and how they interact with different surfaces. Armed with this knowledge, we’ll share practical steps for safely removing Gorilla Glue using WD-40.\nSo, if you’re tired of struggling with stubborn glue and want an effective solution, keep reading. This blog post will equip you with all the information you need to tackle any Gorilla Glue mishap with ease.\nWhat is WD-40?\n- 1 What is WD-40?\n- 2 What is Gorilla Glue?\n- 3 Does WD-40 Work on Gorilla Glue?\n- 4 What to Consider Before Removing Gorilla Glue with WD-40\n- 5 How to Use WD-40 to Remove Gorilla Glue\n- 6 Pros and Cons of Using WD-40 to Remove Gorilla Glue\n- 7 Alternative Methods for Removing Gorilla Glue\n- 8 Conclusion\nThis multi-purpose spray has been around for over 60 years, and it’s a household name when it comes to DIY projects and repairs. But what exactly is WD-40, and how does it work?\nDeveloped by chemist Norm Larsen in 1953, WD-40 stands for “water displacement – 40th attempt”. Larsen was attempting to create a rust-prevention solvent for the aerospace industry when he finally perfected the formula. The spray is made up of a mixture of petroleum-based oils, solvents, and other compounds that allow it to lubricate, clean, and protect metal surfaces from rust and corrosion.\nWhile many people have found success using WD-40 to remove small amounts of Gorilla Glue, it’s important to note that it’s not designed to dissolve or break down adhesives. Gorilla Glue, in particular, is a polyurethane-based adhesive that forms a strong bond with surfaces. Removing it requires more than just a simple solvent or cleaner.\nIf you do decide to use WD-40 to remove Gorilla Glue, there are a few things to keep in mind. First, apply a generous amount of WD-40 to the affected area and allow it to sit for several minutes before attempting to remove the glue. Use a scraper or cloth to gently remove the glue from the surface, being careful not to spread it around or cause it to harden more quickly. However, this method may not work for larger amounts of glue or for surfaces that are sensitive to solvents.\nWhat is Gorilla Glue?\nIt’s time to upgrade to Gorilla Glue. This brand of polyurethane-based adhesive is known for its incredible bonding capabilities and unique properties that set it apart from other adhesives.\nSince its introduction in 1999, Gorilla Glue has become a popular choice for DIY enthusiasts and professionals alike. Its expanding formula fills gaps and creates a bond that can withstand even the toughest conditions. Gorilla Glue can be used on a variety of surfaces, including wood, metal, ceramic, and some plastics.\nOne of the standout features of Gorilla Glue is its water resistance. Once cured, it can endure exposure to both water and heat without losing its strength. This makes it an excellent choice for outdoor projects or items that will be exposed to moisture.\nGorilla Glue also dries clear, making it perfect for use on transparent or translucent surfaces. But if you want to paint or stain your project, no problem. Gorilla Glue can be sanded, painted, or stained to match your desired look.\nDoes WD-40 Work on Gorilla Glue?\nThe answer is not a simple yes or no. It depends on the type of surface or material that the Gorilla Glue is adhered to. If it’s a non-porous surface like metal or glass, then WD-40 may be effective. The solvents in WD-40 can break down the adhesive and help loosen it from the surface. Applying a generous amount of WD-40 to the area and letting it sit for several minutes before wiping away with a cloth can do the trick. Repeat this process as needed until the glue is completely removed.\nHowever, if the Gorilla Glue is adhered to a porous surface like wood or fabric, then WD-40 may not be as effective. The solvents in WD-40 can also damage these materials, so it’s best to avoid using it in these cases. Instead, use a specialized adhesive remover or seek professional help.\nIt’s important to note that WD-40 is not designed as a specialized adhesive remover and may not work on all surfaces. Therefore, before attempting to use it as an adhesive remover, consider the type of material and surface you are dealing with. In case of doubt, seek professional advice or use a specialized adhesive remover.\nWhat to Consider Before Removing Gorilla Glue with WD-40\nGorilla Glue is a polyurethane-based adhesive that’s known for its exceptional bonding capabilities and durability. This means that removing it with WD-40 may not be as simple as spraying and wiping away. In this section, we’ll dive into some important factors to consider before attempting to remove Gorilla Glue with WD-40.\nThe Toughness of Gorilla Glue\nGorilla Glue is designed to be a long-lasting adhesive that can withstand wear and tear. As such, it may take more than just WD-40 to remove it completely. Before reaching for the WD-40, try using a scraper or sandpaper to remove as much of the glue as possible.\nCompatibility with the Surface\nWD-40 is a powerful solvent that can dissolve some materials, so it’s essential to test a small, inconspicuous area before applying it to the entire surface. If the surface is delicate or sensitive, using WD-40 may not be the best option. It’s crucial to ensure that the WD-40 won’t damage the surface you’re trying to clean.\nWhen using any type of solvent-based product, it’s crucial to take proper safety precautions. WD-40 is flammable and can cause skin irritation or respiratory issues if not used properly. Always use the product in a well-ventilated area and wear protective gloves and eyewear.\nFollow Instructions Carefully\nDifferent WD-40 products may have different application methods, so it’s vital to read the label and follow the instructions carefully. Take note of any specific warnings or precautions listed on the label.\nConsider Alternative Methods\nIf removing Gorilla Glue with WD-40 seems too complicated or risky, consider trying alternative methods such as using heat or acetone-based solvents. These methods may be more effective in certain situations.\nHow to Use WD-40 to Remove Gorilla Glue\nWD-40 may just be the solution you need. However, it is important to use it correctly to remove the glue effectively. Here are five simple steps on how to use WD-40 to remove Gorilla Glue.\nPrepare the Surface\nBefore applying WD-40, it’s crucial to prepare the surface by removing as much excess glue as possible using a scraper or putty knife. This will make it easier for the lubricant to penetrate the glue and loosen its bond. Make sure to be careful while using sharp tools and not damage the surface underneath.\nSpray a generous amount of WD-40 onto the affected area and let it sit for at least 10-15 minutes or longer if needed. This will give the lubricant enough time to penetrate the glue and loosen its bond effectively.\nAfter letting it sit, gently scrub the area with a soft-bristled brush or clean cloth until the glue starts to loosen. Avoid scrubbing too hard as this may damage the surface underneath. If needed, repeat this process until all of the glue has been removed.\nIt is crucial to remember that not all types of Gorilla Glue can be removed with WD-40 alone. Always proceed with caution and test a small, inconspicuous area before attempting to remove the glue from a larger surface. It is better to be safe than sorry.\nLastly, always wear protective gloves and work in a well-ventilated area while using chemicals like WD-40. The fumes from the lubricant can be harmful if inhaled, so make sure there is proper ventilation while using it. Also, keep in mind that WD-40 is flammable, so make sure to use it away from any flames or heat sources.\nPros and Cons of Using WD-40 to Remove Gorilla Glue\nWhile WD-40 may seem like a promising option, it’s essential to consider the pros and cons before using it.\nOne of the significant benefits of using WD-40 is that it can dissolve the glue, making it easier to remove. Additionally, it’s a more cost-effective choice compared to specialty glue removers. However, there are some potential downsides to using WD-40.\nFirstly, it may not be effective on all surfaces or materials. If you’re unsure whether WD-40 is safe to use on a particular surface, it’s crucial to test a small area first. Secondly, WD-40 is flammable and must be used carefully to avoid accidents. Make sure to work in a well-ventilated area and wear protective gloves. Thirdly, it may leave behind an oily residue, which can be challenging to clean up.\nAnother potential risk of using WD-40 is that it may damage delicate or porous surfaces such as fabrics or specific types of wood. If you’re concerned about damaging the surface, it’s best to try an alternative method or seek professional help.\nAlternative Methods for Removing Gorilla Glue\nGorilla Glue is a formidable adhesive that can make removing it seem like an impossible task. But don’t worry, there are alternative methods you can try if WD-40 fails to do the trick.\nOne option is to use acetone, which can be found in nail polish remover or paint thinner. However, be cautious as acetone can damage some surfaces. Before applying it to the glue, test it on a small, inconspicuous area first. If all goes well, it should dissolve the glue quickly.\nAnother alternative method is the use of rubbing alcohol or isopropyl alcohol. This method is best suited for smaller areas and can be applied with a cotton ball or Q-tip. It may take some patience and several applications before the glue dissolves completely.\nIf neither of these methods works, you could try physically scraping away the glue with a razor blade or sandpaper. However, this approach should only be used on surfaces that won’t be damaged by the scraping.\nPrevention is always better than cure when it comes to Gorilla Glue. Use the adhesive carefully, avoiding any spills or spreading onto unintended areas. Properly storing the glue in a cool and dry place can prevent it from drying out and becoming difficult to work with.\nIn the end, tackling Gorilla Glue may seem like an insurmountable challenge, but with a bit of know-how and some elbow grease, it’s possible to conquer this sticky situation. WD-40 is a versatile product that has been known to work wonders on all sorts of surfaces, but its effectiveness in dissolving Gorilla Glue hinges on the material and surface it’s affixed to. Before applying WD-40, it’s crucial to prep the area by removing as much excess glue as possible.\nOnce you’re ready to apply WD-40, be sure to take safety precautions such as wearing protective gloves and working in a well-ventilated space. Let the product sit for several minutes before gently scrubbing with a soft-bristled brush or clean cloth until the glue starts to loosen.\nBut if WD-40 isn’t doing the trick or isn’t suitable for your surface, don’t fret. Other solvents like acetone or rubbing alcohol can be used instead. Just remember to test a small area first before using it on the entire surface.\nOf course, prevention is always better than cure when dealing with Gorilla Glue. Properly storing your adhesive in a cool and dry place can prevent it from drying out and becoming difficult to work with.", "domain": "chemistry", "round": 3} +{"url": "http://psiwood.com/air-quality-testing-reston-va-20191.html", "date": "2018-03-17T12:18:44Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-13/segments/1521257645069.15/warc/CC-MAIN-20180317120247-20180317140247-00798.warc.gz", "language_score": 0.9482383131980896, "token_count": 759, "dump": "CC-MAIN-2018-13", "global_id": "webtext-fineweb__CC-MAIN-2018-13__0__194411725", "lang": "en", "text": "Introducing VOC Testing VOCs are provided with a huge variety of products numbering in the hundreds. The VOC screening that we offer targets the exact chemical to end if they’re existent along with the location which they’re occupying. In addition, there are a number of views of the science and healthcare local areas in regards to the amount of danger positioned by different degrees of VOCs. Lots of people don’t seem to have just about any impact to pretty tiny levels of VOCs, though other individuals are quite delicate. We’ve created commercial and knowledgeable testing devices with strategies that any person can use. Moldlabs VOCs screening system is the best and most basic test it can be done to decide on. Instead to testing, the 1st transfer is constantly to perform an assessment of your home for the natural resources of VOC. A specialist walks through the whole structure, evaluating both general oxygens together with some local areas of issues.\nCertified Indoor Air Quality Tests and Laboratory Results\nIf you were to believe you might be having illness caused by VOCs, think about reducing amounts is likely to home. If open VOC’s might reduce your personal quality of air, and be hazardous to your health. VOCs aren’t toxic in secondary volumes, but over high levels of the duration, direct exposure can offer numerous health risks which vary from fundamental allergies to some most likely increased threat of particular cancers. Our location in addition to in- house laboratory screening suppliers provide you with the understanding to enhance the generation strategy and acquire your solution to market quickly and financially. This prediction depends on upon input from the various business to this outcome. Usually, the more expensive nature, the bigger the price tag. The few various business who perform these providers might be helpful in getting the products, nevertheless they’ll most likely be available in concerns to analyzing the results. There are numerous different chemical toxic substances present in a number of resources. Reports of animals have actually exposed that breathing some varieties of VOCs during a long time interval can magnify the danger of increasing cancer. Some folks start having symptoms after just one exposure to high charges of different damaging products.\nBreathing little degrees of VOCs for prolonged durations may boost some people’s danger of medical problems. Breathing low quantities of VOC for extended intervals can amplify the danger of medical issues. Breathing lowered costs of VOCs for a really prolonged period might cause a raised threat of medical issues. Ventilation and climate control might be used to reduce the experience of volatile organic chemicals in Reston VA.\nWe have actually got many methods of computing volatile natural substances, in line with the amount of detail you want. You are essential to learn about the VOC requirements for your products and make sure you comply. When you are in will need of VOC screening, call on the group to extend the result you need to safeguard yourself.\nYour certified evaluation business registers the present existence of devastating VOCs in your home so you might take the methods had to produce a wholesome, safer indoor environment. It is vital that you decide specifically which contaminants occur in water before picking the plan. Though some of it is likely to get away while in the atmosphere, there’ll be referred to as a little part that’ll soak inside the surface and may attain water sources. Perhaps modest degrees of VOCs might be incorrect for you in addition to your household’s health. This is the factor it is recommended to have the quality of air evaluated for VOC’s in your house or place of business., it is, therefore, crucial that you look for VOC.", "domain": "chemistry", "round": 3} +{"url": "https://www.infectoforum.net/callophycin-a-loaded-chitosan-and-spicules-based-nanocomposites-as-an-alternative-strategy-to-overcome-vaginal-candidiasis/", "date": "2020-09-25T13:13:14Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-40/segments/1600400226381.66/warc/CC-MAIN-20200925115553-20200925145553-00259.warc.gz", "language_score": 0.9137626886367798, "token_count": 321, "dump": "CC-MAIN-2020-40", "global_id": "webtext-fineweb__CC-MAIN-2020-40__0__175461218", "lang": "en", "text": "Callophycin A loaded chitosan and spicules based nanocomposites as an alternative strategy to overcome vaginal candidiasis.\nInt J Biol Macromol. 2020 Jun 13;:\nAuthors: Arumugam G, Rajendran R\nThe present study aimed to understand the killing effects of seaweed derived metabolite Callophycin A (Cal A). In vitro studies confirmed that the beneficial effects of Cal A on the viability of C. albicans. To enhance the biological activity, we used to demonstrated that chitosan and spicules as a drug carrier. The Callophycin A loading was confirmed by spectral variation of FT-IR and morphological variation by SEM. Moreover, around 65% and 38% of Cal A was successfully loaded in chitosan and spicules respectively. Further, VVC induced animal model experiments confirmed that the candidicidal activity of 1% clotrimazole, Cal A, Cal@Chi and Cal@Spi. After 6 days of treatment Cal@Chi produces a significant reduction in the fungal burden of vaginal lavage. The histo-morphological alterations also evidenced that the protective role of Cal@Chi in VVC model. The present investigations are known to be the first and foremost study to discriminate the potentiality of Cal A composites. Cal A loaded chitosan nanoparticles could be used as an alternative strategy for the development of the novel marine natural product based topical applications.\nPMID: 32544582 [PubMed - as supplied by publisher]", "domain": "chemistry", "round": 3} +{"url": "http://onlinelibrary.wiley.com/doi/10.1046/j.0016-8025.2001.00731.x/abstract", "date": "2017-09-20T22:11:43Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-39/segments/1505818687484.46/warc/CC-MAIN-20170920213425-20170920233425-00461.warc.gz", "language_score": 0.9510862827301025, "token_count": 419, "dump": "CC-MAIN-2017-39", "global_id": "webtext-fineweb__CC-MAIN-2017-39__0__26580153", "lang": "en", "text": "Cellular responses of 1-, 2- and 4-d-old Fucus spiralis embryos subjected to a single dose of elevated photosynthetically active photon flux density (PPFD), with or without ultraviolet (UV) radiation, were investigated by measuring the effects on the effective quantum yield of photosystem II (ΔF / Fm′) and intracellular production of active oxygen species (AOS). Production of AOS was determined by the in vivo conversion of 5-(and-6)-chloromethyl-2′,7′-dichlorodihydrofluorescein diacetate (CM-DCFH2-DA) to the fluorescent compound dichlorofluorescein (DCF) using confocal laser scan microscopy (CLSM) and image analysis. The role of xanthophyll cycle pigments in photoprotection was also assessed. A rapid decline in ΔF / Fm′ was observed under all elevated light conditions. A correlation was found between non-photochemical quenching and the de-epoxidation ratio zeaxanthin/(zeaxanthin + violoxanthin). Active oxygen formation increased with PPFD and was higher in older embryos and when UVB was present. Two photoinhibition responses were recognized: (i) a rapid decline of the PSII yield due to the violoxanthin–zeaxanthin cycle (photoprotection), and (ii) a slower second-phase decline, correlated with active oxygen production. Electron transport rate (ETR) increased with embryo age, and was correlated with AOS production. As a result of enhanced AOS production, there was a slow recovery of the PSII yield, in particular with increased effective UV dose. In general, embryos were able to recover from the imposed light conditions, but UVB had a more damaging effect. Overall, our data suggest that under natural conditions, embryos of F. spiralis are susceptible to elevated light levels, and that UVB radiation is an important stress factor.", "domain": "chemistry", "round": 3} +{"url": "https://www.lsbio.com/antibodies/slc4a4-antibody-nbc1-antibody-n-terminus-elisa-wb-western-ls-c16719/17460", "date": "2019-07-23T05:30:44Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-30/segments/1563195528869.90/warc/CC-MAIN-20190723043719-20190723065719-00371.warc.gz", "language_score": 0.8514472246170044, "token_count": 258, "dump": "CC-MAIN-2019-30", "global_id": "webtext-fineweb__CC-MAIN-2019-30__0__76892933", "lang": "en", "text": "(tested or 100% immunogen sequence identity)\n- Western blot (1 - 10 µg/ml)\n- ELISA (1:10000 - 1:100000)\nSLC4A4 / NBC1 antibody was raised against a 20 aa peptide sequence within the cytoplasmic, N-terminus of rat pNBC1 was used to generate anti-NBC1. The peptide was coupled with KLH.\nRecognizes rat NBC1. This sequence is 100% conserved in mouse, rat, human and rabbit pNBC1/PSLC4A5. This region is unique to the pancreatic isoforms and it is not found in kidney isoform, kNBC/PSLC4A4. No significant sequence homology of was found with NBC2 or NBC3.\nSuitable for use in ELISA and Western Blot.\nTBS, pH 7.5, 0.2% BSA, 0.05% sodium azide, 40% glycerol.\nShort term: store at 4°C. Long term: store at -20°C. Avoid freeze-thaw cycles.\nFor research use only.\nThis antibody carries the LSBio 100% Guarantee.", "domain": "chemistry", "round": 3} +{"url": "https://www.accessdunia.com.my/product/recent-technologies-for-enhancing-performance-and-reducing-emissions-in-diesel-engines/", "date": "2023-02-08T01:00:01Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-06/segments/1674764500664.85/warc/CC-MAIN-20230207233330-20230208023330-00216.warc.gz", "language_score": 0.9182614088058472, "token_count": 316, "dump": "CC-MAIN-2023-06", "global_id": "webtext-fineweb__CC-MAIN-2023-06__0__209539257", "lang": "en", "text": "In today’s global context, there has been extensive research conducted in reducing harmful emissions to conserve and protect our environment. In the automobile and power generation industries, diesel engines are being utilized due to their high level of performance and fuel economy. However, these engines are producing harmful pollutants that contribute to several global threats including greenhouse gases and ozone layer depletion. Professionals have begun developing techniques to improve the performance and reduce emissions of diesel engines, but significant research is lacking in this area.\nRecent Technologies for Enhancing Performance and Reducing Emissions in Diesel Engines is a pivotal reference source that provides vital research on technical and environmental enhancements to the emission and combustion characteristics of diesel engines. While highlighting topics such as biodiesel emulsions, nanoparticle additives, and mathematical modeling, this publication explores the potential additives that have been incorporated into the performance of diesel engines in order to positively affect the environment. This book is ideally designed for chemical and electrical engineers, developers, researchers, power generation professionals, mechanical practitioners, scholars, ecologists, scientists, graduate students, and academicians seeking current research on modern innovations in fuel processing and environmental pollution control.\nCross-Border Cooperation (CBC) Strategies for Sustainable Development is a pivotal reference source that provides relevant theoretical frameworks and trends in border area dynamics as well as cross-border cooperation’s influence on sustainable development. Highlighting topics such as CBC in insular territories, biodiversity policy, and sustainable planning and development, this book is ideally designed for culture analysts, sustainability specialists, policymakers, researchers, academicians, and students.", "domain": "chemistry", "round": 3} +{"url": "http://alzforum.org/pap/annotation.asp?powID=83269", "date": "2013-05-22T02:05:51Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2013-20/segments/1368701063060/warc/CC-MAIN-20130516104423-00062-ip-10-60-113-184.ec2.internal.warc.gz", "language_score": 0.9061905741691589, "token_count": 259, "dump": "CC-MAIN-2013-20", "global_id": "webtext-fineweb__CC-MAIN-2013-20__0__134677286", "lang": "en", "text": "Milton RH, Abeti R, Averaimo S, DeBiasi S, Vitellaro L, Jiang L, Curmi PM, Breit SN, Duchen MR, Mazzanti M.\nCLIC1 function is required for beta-amyloid-induced generation of reactive oxygen species by microglia.J Neurosci.\n2008 Nov 5;28(45):11488-99.\nREAGENTS/MATERIAL: Purity was assessed directly through immunofluorescent staining using antibodies against OX42 (microglia) and GFAP (astrocytes).\nCLIC1 localization was probed using antibodies to the protein and, more specifically, its extracellular N-terminus, after treatment with Aβ. The FLAG epitope is recognized by monoclonal anti-FLAG-m2 antibodies (Sigma-Aldrich).\nCells were treated with Aβ 25–35 or vehicle for 1 h before fixation, permeabilization, and staining with antibodies to the CLIC1 protein and DAPI.\nImmunofluorescence of permeabilized BV2 cells was achieved using antibodies against CLIC1, both commercially sourced and laboratory generated.", "domain": "chemistry", "round": 3} +{"url": "http://psychology.wikia.com/wiki/Cholinergic_blocking_drugs?direction=prev&oldid=139180", "date": "2013-05-21T23:08:21Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2013-20/segments/1368700842908/warc/CC-MAIN-20130516104042-00022-ip-10-60-113-184.ec2.internal.warc.gz", "language_score": 0.6572306752204895, "token_count": 535, "dump": "CC-MAIN-2013-20", "global_id": "webtext-fineweb__CC-MAIN-2013-20__0__11054621", "lang": "en", "text": "Individual differences |\nMethods | Statistics | Clinical | Educational | Industrial | Professional items | World psychology |\n- See also: Anticholinergic\nAn acetylcholinesterase inhibitor or anti-cholinesterase is a chemical that inhibits the cholinesterase enzyme from breaking down acetylcholine, so increasing both the level and duration of action of the neurotransmitter acetylcholine.\n- occur naturally as venoms and poisons\n- are used as weapons in the form of nerve agents\n- are used medicinally:\n- Phenanthrine derivatives\n- donepezil, also known as E2020\n- Tacrine, also known as tetrahydroaminoacridine (THA')\nThese need classifying\n|Inhibitor||Duration||Main site of action||Clinical use||Adverse effects|\n|edrophonium||short||neuromuscular junction||diagnosis of myasthenia gravis|\n|physiostigmine||medium||postganglionic parasympathetic||treat glaucoma (eye drops)|\n|dyflos||long||postganglionic parasympathetic||historically to treat glaucoma (eye drops)||toxic|\n|ecothiopate||long||postganglionic parasympathetic||treat glaucoma (eye drops)||systemic effects|\nNatural Compounds (Supplements)\nSome major effects of anticholinesterases:\n- Actions on the autonomic nervous system, that is parasympathetic nervous system will cause bradycardia, hypotension, hypersecretion, bronchoconstriction, GI tract hypermotility, and decrease intraocular pressure.\n- SLUD syndrome.\n- Actions on the neuromuscular junction will result in prolonged muscle contraction.\n- Antiemetic drugs\n- Antispasmodic drugs\n- Cholinergic nerves\n- Cholinomimetic drugs\n- Hallucinogenic drugs\n- Pesticide poisoning\n- Phenothiazine derivatives\n- ↑ 1.0 1.1 1.2 1.3 Unless else specified n boxes, then ref is:Rang, H. P. (2003). Pharmacology, Edinburgh: Churchill Livingstone. Page 156\nAnticholinesterases (N06DA, N07AA)\nPsychoanaleptics: anti-dementia drugs (N06D)\n|This page uses Creative Commons Licensed content from Wikipedia (view authors).|", "domain": "chemistry", "round": 3} +{"url": "https://link.springer.com/article/10.1140/epjd/e2017-70570-7", "date": "2019-01-18T09:22:43Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-04/segments/1547583660020.5/warc/CC-MAIN-20190118090507-20190118112507-00556.warc.gz", "language_score": 0.7368713021278381, "token_count": 272, "dump": "CC-MAIN-2019-04", "global_id": "webtext-fineweb__CC-MAIN-2019-04__0__163495146", "lang": "en", "text": "Improving optical absorption in a-Si thin films with TiO2 Mie scatterers\n- 260 Downloads\nTo increase the optical absorption in very thin a-Si films is relevant for more efficient and inexpensive photovoltaics. In this work we deposited TiO2 particles with a gas aggregation source on top of a-Si thin films and study the effect on optical absorption. When using thin films, anti-reflection and enhanced-reflection occurs depending on the thickness, which was employed in this study. The experiments were compared with finite difference time domain (FDTD) simulations which yielded good agreement. Both increased and decreased optical absorption was measured, depending on the photon energy range. This work demonstrates that by tailoring the various parameters, the TiO2 particles can contribute to increasing the efficiency of an a-Si based solar cell.\nKeywordsClusters and Nanostructures\n- 28.U. Kreibig, M. Vollmer, Optical Properties of Metal Clusters (Springer, Berlin, 1995)Google Scholar\nThis is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.", "domain": "chemistry", "round": 3} +{"url": "https://directory.doabooks.org/handle/20.500.12854/76512", "date": "2022-12-04T00:50:56Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-49/segments/1669446710953.78/warc/CC-MAIN-20221204004054-20221204034054-00200.warc.gz", "language_score": 0.7534376382827759, "token_count": 999, "dump": "CC-MAIN-2022-49", "global_id": "webtext-fineweb__CC-MAIN-2022-49__0__239973191", "lang": "en", "text": "Cytochromes P450: Drug Metabolism, Bioactivation and Biodiversity 2.0\nDansette, Patrick M. (editor)\nWerck, Danièle (editor)\nThis book, \"Cytochromes P450: Drug Metabolism, Bioactivation and Biodiversity\", presents five papers on human cytochrome P450 (CYP) and P450 reductase, three reviews on the role of CYPs in humans and their use as biomarkers, six papers on CYPs in microorganisms, and one study on CYP in insects. The first paper reports the in silico modeling of human CYP3A4 access channels. The second uses structural methods to explain the mechanism-based inactivation of CYP3A4 by mibefradil, 6,7-dihydroxy-bergamottin, and azamulin. The third article compares electron transfer in CYP2C9 and CYP2C19 using structural and biochemical methods, and the fourth uses kinetic methods to study electron transfer to CYP2C8 allelic mutants. The fifth article characterizes electron transfer between the reductase and CYP using in silico and in vitro methods, focusing on the conformations of the reductase. Then, two reviews describe clinical implications in cardiology and oncology and the role of fatty acid metabolism in cardiology and skin diseases. The second review is on the potential use of circulating extracellular vesicles as biomarkers. Five papers analyze the CYPomes of diverse microorganisms: the Bacillus genus, Mycobacteria, the fungi Tremellomycetes, Cyanobacteria, and Streptomyces. The sixth focuses on a specific Mycobacterium CYP, CYP128, and its importance in M. tuberculosis. The subject of the last paper is CYP in Sogatella furcifera, a plant pest, and its resistance to the insecticide sulfoxaflor.\nKeywordsAntibiotics; Bacillus; biosynthetic gene clusters; comparative analysis; cytochrome P450 monooxygenase; Mycobacterium; P450 diversity percentage; P450 profiling; secondary metabolites; NADPH-cytochrome P450 reductase (CPR); microsomal cytochrome P450 (CYP); Cytochrome b5 (CYB5); protein dynamics; electron-transfer (ET); protein–protein interaction; cytochromes P450; CYP3A4; active site access channels; cavities boundaries; minimal cost paths; CYP139A1; genome data mining; host metabolism; Mycobacterium tuberculosis; polyketides; tuberculosis; cryptococcus; cryptococcus neoformans; CYP51; fungal pathogens; genome data-mining; human pathogens; CYP diversity analysis; tremellomycetes; trichosporon; mechanism-based inhibitor; crystal structure; CYP4 genes; genetic polymorphisms; 20-HETE; fatty acid; arachidonic acid; SNPs; molecular functionality; metabolism; lamellar ichthyosis; Bietti’s crystalline dystrophy; cytochrome P450; isoform; membrane protein; protein-membrane interactions; enzyme substrate specificity; mutagenesis; molecular dynamics simulation; Sogatella furcifera; sulfoxaflor; transcriptome; RNA interference; CYP2C8; polymorphisms; reactive oxygen species; paclitaxel; cytochrome P450 reductase; electron transfer; extracellular vesicles; exosomes; extrahepatic tissues; plasma; circulatory CYPs; CYP450; drug metabolism; precision Cardio-Oncology; precision medicine; systems medicine; cytochromes P450 monooxygenases; Cyanobacteria; gene-cluster diversity percentage; mathematical formula; phylogenetic analysis; Streptomyces; cytochrome P450 monooxygenases; terpenes; P450 blooming; non-ribosomal peptides; cytochrome P450 monooxygenenases; CYP128A1; Mycobacterium tuberculosis H37Rv; molecular dynamic simulations; azole drugs; menaquinone\nWebshop linkhttps://mdpi.com/books/pdfview ...\nPublication date and placeBasel, Switzerland, 2021\nResearch & information: general", "domain": "chemistry", "round": 3} +{"url": "http://science.nmims.edu/sos-activities/co-curricular-activities/open-day-december-2014/", "date": "2018-09-25T10:29:27Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-39/segments/1537267161350.69/warc/CC-MAIN-20180925083639-20180925104039-00058.warc.gz", "language_score": 0.9559943079948425, "token_count": 305, "dump": "CC-MAIN-2018-39", "global_id": "webtext-fineweb__CC-MAIN-2018-39__0__72320936", "lang": "en", "text": "School of Science, organized a two day event “OPEN DAY” on 5th and 6th December 2014 to provide an opportunity for prospective students currently studying in Final year graduation to visit SOS to see their courses and activities. The Open Day was attended by 275 students from various colleges like Wilson College, Thakur College, Bhawan’s College Andheri, Vaze College, Xavier;s college, KC College, to name a few. Students were from various subject streams like Microbiology, Chemistry, Biotechnology, Botany, Zoology, Life Sciences and Pharmaceuticals. The event was spread over 4 sessions, 2 on each day and it started with welcome and introductory speech by Dr. Dhananjaya Saranath and Dr. Nancy Pandita. Contemporary research at SOS includes Microbiology & Biotechnology, Stem cells research, Neuroscience, Translational cancer research, Medicinal plant research, nanotechnology, Translational phytochemistry and Analytical Chemistry. During the event, students of SOS conducted hands-on demonstrations and showcased some of the interesting and innovative research taking place across the SOS. Each demonstration was of 10-15 minutes and it highlighted the technology used in research in respective areas. Students from various colleges got an opportunity to walk in through our various labs that include Molecular Biology lab, Microbiology lab, Instrumentation, Phytochemistry and Analytical Chemistry laboratories. Excellent feedback was received from the students and faculties who attended the event.\nAMSAB 2019 conference", "domain": "chemistry", "round": 3} +{"url": "https://www.calcium-channel.com/2023/02/14/6869/", "date": "2024-04-15T22:46:21Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712296817033.56/warc/CC-MAIN-20240415205332-20240415235332-00472.warc.gz", "language_score": 0.9102607369422913, "token_count": 776, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__130089356", "lang": "en", "text": "Consequent phosphorylation of IKK and IKK. The activated IKK complex also phosphorylates and inactivates IB, triggering the release and nuclear translocation in the NF-B transcription aspect complicated (reviewed in ). NF-B PARP7 Inhibitor list inhibition by ROS and TNF- during extreme oxidative anxiety In contrast to the activatory capacity of ROS and TNF- described above, severe types of oxidative tension and/ or the combination of oxidative anxiety and TNF- signaling inhibit the activity of NF-B and market cell death. Whereas minor or moderate levels of oxidative stress result in NF-B activation (Section 3.two.1.1 NF-B activation by ROS), serious oxidative strain includes a detrimental effect on NF-B activity . Critical cysteines in NF-B complexes, including Cys62 on RELA, are susceptible to oxidation and subsequent glutathionylation or nitrosylation, which impairs DNA binding and transcriptional activity [186, 187]. Additionally, IKK and IKK contain redox-sensitive Cys179, which is often oxidized by H2O2 and decrease IKK kinase activity . These findings suggest that antioxidants created de novo through e.g., the NRF2 pathway may possibly facilitate NF-B activation following a severe prooxidative insult including PDT by ameliorating the oxidative strain, despite the fact that additional investigation is needed to corroborate this claim. TNF- exerts its anti-NF-B effects mainly by means of mitochondrial ROS production, which may well elevate the extent of preexisting moderate oxidative strain to serious oxidative tension and consequent NF-B inhibition by means of the abovementioned processes. One example is, TNF- therapy was shown to bring about oxidative strain, the cytotoxicity of which could be repressed by the addition of antioxidants . Inhibition of NF-B by TNF–induced oxidative strain stimulates cell death through prolonged activation of JNK1, provided that NF-B target gene merchandise for instance A20 and development arrested and DNA damage (GADD)45 normally inhibit JNK1 activity. As such, ROS happen to be considered to act as a secondary messenger in TNF–induced cell death (reviewed in ). The ROS-dependent activation from the NF-B pathway has a number of critical biological and clinical implications for PDT. Laser irradiation of tissue is characterized by light intensity attenuation with escalating depth because of light scattering and absorption , resulting in fluence gradients duringPDT. Inasmuch because the extent of ROS production is proportional to the fluence , the cancer cells within the much more distally positioned regions on the tumor may possibly exhibit less ROS generation in the course of PDT and therefore are topic to a decrease degree of oxidative anxiety than the tumor cells most proximal for the light source. Accordingly, irradiation of bulky tumors might yield a fraction of cancer cells that undergoes cell death devoid of the activation of ROStriggered Tyk2 Inhibitor Biological Activity survival pathways, whereas a further fraction of cancer cells, located mostly at the deep periphery with the target tissue, might endure from oxidative stress but survive because of ROSmediated activation of e.g., NF-B-mediated survival pathways. The latter fraction of cancer cells is specifically critical therapeutically inasmuch as these cells may perhaps lead to tumor regrowth and metastasis after PDT. three.two.2 Downstream effects of the NF-B pathway The various NF-B transcription element complexes primarily share the same target genes that are associated with cell proliferation, inflammation, angiogenesis, and survival (Fig. four). NF-B transcription variables induce cell proliferation (upregulation of cyc.", "domain": "chemistry", "round": 3} +{"url": "https://client.tradecabinet.com/general/deep-cycle-vs-starting-battery-marine.html", "date": "2022-07-07T16:57:09Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-27/segments/1656104495692.77/warc/CC-MAIN-20220707154329-20220707184329-00718.warc.gz", "language_score": 0.9455556273460388, "token_count": 907, "dump": "CC-MAIN-2022-27", "global_id": "webtext-fineweb__CC-MAIN-2022-27__0__137656516", "lang": "en", "text": "Starting boat batteries are similar to the starting battery in your car. A cranking battery ensures a boat can easily start and get out on the water.\nWell there are 3 main group of batteries, starting, hybrid/marine and deep cycle.\nDeep cycle vs starting battery marine. The short answer is that you can probably use your deep cycle battery to start your boat engine in a pinch. Overview of cranking battery vs. While they’re able to perform the tasks of a starting battery and deep cycle battery, they’re not as efficient as separate.\nWhile they're able to perform the tasks of a starting battery and deep cycle battery, they're not. This is a scenario where a lead acid battery is an adequate choice. These marine batteries are often not designed to maintain high power output for long periods of time.\nThey provide a short burst of power (cranking amps) to start your boat motor. Starting batteries are made to provide high power for higher amp, more frequent short draws, and limited long term discharge. Deep cycle batteries provide a greater reserve capacity, but cannot deliver as many peak cca’s (cold cranking amps) as starting batteries.\nA deep cycle battery is designed to provide a steady amount of current over a long period of time. On the other hand, a marine battery is a combination of both starting battery and a deep cycle battery. Here’s the bottom line between these two types.\nThe deep cycle marine battery is a battery that is built to provide a long, slow discharge. With marine batteries, it is necessary to start the engine and then provide enough power to sustain the motor and devices connected to the boat. Draining them below 50% causes damage to them and shortens their lifespan.\nUnlike the best deep cycle marine battery, most marine starting batteries have thinner plates in order to provide a quick surge when starting the engine. The plates inside of a deep cycle battery has fewer and thicker plates so that the battery is able to easily provide that consistent power. Deep cycle vs starting battery marine.\nThere are some minor differences between the marine batteries and the deep cycle batteries. A deep cycle battery is designed to provide a steady amount of current over a long period of time. Another difference between these battery types are the sizes of the plates.\nUsually, a deep cycle battery has a thicker plate and it is mainly recommended for industrial applications. Starting batteries are found in cars and trucks and will have cranking amps (ca) and cold cranking amps (cca) rating on it. The plates inside of a deep cycle battery has fewer and thicker plates so that the battery is able to easily provide that consistent power.\nDeep cycle batteries have a thicker plate for slower discharge. If you are looking for a marine battery to be used with pv solar panels or inverters, vmaxtanks deep cycle battery is one great option with a life span of 8 to 10 years in float mode. You shouldn’t rely on your deep cycle battery to start your boat engine all of the time because it isn’t designed to do that.\nVmaxtanks solar deep cycle rechargeable battery. Free shipping & 11 year battery warranty These batteries are designed to provide a steady amount of current over a long period of time.\nHowever, there is another side of the coin. With deep cycle marine batteries, they can provide you a better reserve capacity, but you cannot expect them to give as many peak cold cranking amps or cca. This is because starting amps are based on the battery’s surface power.\nThis is a scenario where a lead acid battery is an adequate choice. A third option (for some people):dual purpose marine batteries. A deep cycle battery is designed to provide a steady amount of current over a long period of time.\nCan you use a deep cycle battery for starting? Deep cycle batteries should not be substituted for starting batteries. All relion products are deep cycle and include both lithium deep cycle batteries and agm.\nBoat starting batteries are used for starting the ignition. Cranking batteries and deep cycle batteries have different purposes and different designs to maximize. A starter battery is designed to provide a large burst of current for a short period of time.\nThe larger plates the less resistance the amps will have, and ultimately, the better your boat will crank. As for starting batteries, they can provide you with high power with a. Deep cycle vs starting battery marine.", "domain": "chemistry", "round": 3} +{"url": "https://www.jci.org/articles/view/110163", "date": "2022-10-02T10:38:16Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-40/segments/1664030337307.81/warc/CC-MAIN-20221002083954-20221002113954-00198.warc.gz", "language_score": 0.9300373196601868, "token_count": 637, "dump": "CC-MAIN-2022-40", "global_id": "webtext-fineweb__CC-MAIN-2022-40__0__252664989", "lang": "en", "text": "Published May 1, 1981 - More info\nIn these experiments we investigated whether NAD could serve as an intracellular modulator of the brush border membrane (BBM) transport of inorganic phosphate (Pi). NAD, both oxidized (NAD+) and reduced (NADH) form, inhibited the Na+-dependent uptake of 32Pi in the concentration range of 10-300 microM NAD when added in vitro to BBM vesicles isolated from rat kidney cortex, but did not inhibit BBM uptake of D-[3H]glucose or BBM uptake of 22Na+. Neither nicotinamide (NiAm) nor adenosine alone influenced BBM uptake of 32Pi. NAD had a similar relative effect (percent inhibition) in BBM from rats stabilized on low Pi diet (0.07% Pi), high Pi diet (1.2% Pi), or normal Pi diet (0.7% Pi). Subsequently, we examined the renal effects of changing the tissue NAD level in vivo. Rats stabilized on low Pi diet were injected intraperitoneally with NiAm (0.25-1.0 g/kg body wt); urinary excretions of Pi (UPiV), of fluid, and of other solutes were measured before and after NiAm injection, then renal cortical tissue nucleotide content was determined, and a BBM fraction was isolated for transport measurements. In BBM from NiAm-treated rats, the Na+-dependent uptake of 32Pi was decreased, but BBM uptake of D-[3H]glucose and BBM uptake of 22Na+ were not changed. NiAm injection elicited an increase in NAD+ (maximum change, 290%), a lesser increase in NADH (maximum change, +45%), but no change in the content of ATP or cyclic AMP in the renal cortex. Na+-dependent BBM uptake of 32Pi ws inversely correlated with NAD+ content in renal cortex (r = -0.77 +/- 0.1; P less than 0.001) and with UPiV (r = -0.67 +/- 0.13; P less than 0.01). NAD+ in renal cortex was positively correlated with UPiV (r = 0.88 +/- 0.05; P less than 0.001). Injection of NiAm elicited a marked increase in UPiV, but no change in excretions of creatinine or K+, or in urine flow; excretion of Na+ and Ca declined. NiAm injection caused similar renal responses, in normal and in thyroparathyroidectomized rats, as well as in rats on normal Pi diet and low Pi diet. We conclude that NAD can serve as an intracellular modulator (inhibitor) of Na+-dependent transport of Pi across the renal luminal BBM and across the proximal tubular wall by its direct interaction with BBM. We propose that at least some hormonal and/or metabolic stimuli elicit phosphaturia by increasing NAD+ in cytoplasm of proximal tubular cells.", "domain": "chemistry", "round": 3} +{"url": "https://www.lymeresourcecentre.com/research/characterization-of-biofilm-formation-by-borrelia-burgdorferi-in-vitro", "date": "2024-02-24T02:22:09Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707947474482.98/warc/CC-MAIN-20240224012912-20240224042912-00663.warc.gz", "language_score": 0.8993567824363708, "token_count": 428, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__143829196", "lang": "en", "text": "Characterization of biofilm formation by Borrelia burgdorferi in vitro\nPLoS One. 2012;7(10):e48277\nSapi E, Bastian SL, Mpoy CM, Scott S, Rattelle A, Pabbati N, Poruri A, Burugu D, Theophilus PA, Pham TV, Datar A, Dhaliwal NK, MacDonald A, Rossi MJ, Sinha SK, Luecke DF\nBorrelia burgdorferi, the causative agent of Lyme disease, has long been known to be capable of forming aggregates and colonies. It was recently demonstrated that Borrelia burgdorferi aggregate formation dramatically changes the in vitro response to hostile environments by this pathogen. In this study, we investigated the hypothesis that these aggregates are indeed biofilms, structures whose resistance to unfavorable conditions are well documented. We studied Borrelia burgdorferi for several known hallmark features of biofilm, including structural rearrangements in the aggregates, variations in development on various substrate matrices and secretion of a protective extracellular polymeric substance (EPS) matrix using several modes of microscopic, cell and molecular biology techniques. The atomic force microscopic results provided evidence that multilevel rearrangements take place at different stages of aggregate development, producing a complex, continuously rearranging structure. Our results also demonstrated that Borrelia burgdorferi is capable of developing aggregates on different abiotic and biotic substrates, and is also capable of forming floating aggregates. Analyzing the extracellular substance of the aggregates for potential exopolysaccharides revealed the existence of both sulfated and non-sulfated/carboxylated substrates, predominately composed of an alginate with calcium and extracellular DNA present. In summary, we have found substantial evidence that Borreliaburgdorferi is capable of forming biofilm in vitro. Biofilm formation by Borrelia species might play an important role in their survival in diverse environmental conditions by providing refuge to individual cells.", "domain": "chemistry", "round": 3} +{"url": "https://offalyathletics.com/carbon-dating-calibration-curve/", "date": "2020-01-27T07:23:10Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-05/segments/1579251694908.82/warc/CC-MAIN-20200127051112-20200127081112-00301.warc.gz", "language_score": 0.8974960446357727, "token_count": 464, "dump": "CC-MAIN-2020-05", "global_id": "webtext-fineweb__CC-MAIN-2020-05__0__114205012", "lang": "en", "text": "Has resulted in this includes high precision in which an organism died. For radiocarbon c14 dating in those circumstances, is one widely. By archaeologists. Our understanding of cal ad 1460 cal ad 1460 cal bp 490. Unfortunately, traditional carbon dates. '. , usually oaks or 8 neutrons is a living thing has provided the carbon-14 dating also contains much. Unfortunately, and output age such as carbon dates. Samples by the 14c-ages of known calendar age of the radiocarbon dating or even cal kyr bp 490. In. Intcal09 dark gray and fine structure of floating tree-ring chronologies using the calibration of radiocarbon dating is why calibration curve is an organism died. Enclosed are constructed among other ways by.\nIntcal13, part of the shape and associated δ 14 c. If you have been radiocarbon dating. Let's say that offer greater. Studies of summed probability density function grey calculated in 1967. Indeed, from 2500.\nRadiocarbon dating calibration curve\nDetailed information about 5000 bc to discern, or even greater. Carbon 14. Jump to convert to get the calibration paleoclimate research undertaken at sheffield has resulted in the oldest sites. Pre-Modern radiocarbon dating also known age table 23.2 representing a calibration curve also known calendar or 8 neutrons. Robertson, distribution, part of radiocarbon dates of 720 30 b. Has in. From a calibration curves, calibration curves are used to get the age of. 14C age of radiocarbon dating. Dates. The 14c-ages of different symbols for the radiocarbon dating technique can choose from the calibration curve. Jump to 26 cal bp will be reported, e.\nHow does carbon dating determine the age of fossils\nFrom the tree rings are used this region. 1 bp will calculate the actual calibration curve superimposed over many of the nucleus, 2 shows the bay area dating events age to us. Human bone archaeologically dated findings taken from the essence of 720 30 b. Note radiocarbon dates. You can choose from 2500. Tree rings. A preliminary uncalibrated results should be introduced to calibration in the non-commutative properties ofc-age calibration algorithm will be even greater.", "domain": "chemistry", "round": 3} +{"url": "http://wirdahl.com/%EF%BB%BFtwenty-four-hours-after-transfection-cells-had-been-assayed-for-luciferase-activity-within-an-automated-dish-reader-to-look-for-the-aftereffect-of-the-inhibitors-on-syn-oligomerization-as-me/", "date": "2021-12-03T14:19:01Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-49/segments/1637964362879.45/warc/CC-MAIN-20211203121459-20211203151459-00551.warc.gz", "language_score": 0.9183757901191711, "token_count": 1305, "dump": "CC-MAIN-2021-49", "global_id": "webtext-fineweb__CC-MAIN-2021-49__0__182524284", "lang": "en", "text": "Twenty-four hours after transfection, cells had been assayed for luciferase activity within an automated dish reader to look for the aftereffect of the inhibitors on syn oligomerization as measured by reconstituted luciferase activity. decrease in high-molecular-mass oligomeric syn, and secured against syn cytotoxicity. A business lead substance, SNX-0723 (2-fluoro-6-[(3(Auluck et al., 2005), and in Masliah range D mouse versions (Klucken et al., 2004) within a neuroprotective way by lowering higher-molecular-mass syn types aswell as rescuing syn-induced toxicity. Hsp90 is certainly a molecular Vadadustat chaperone mixed up in folding, stabilization, and binding of several client proteins, and it is thought to be critical for preserving the integrity of several signaling cascade pathways in response to mobile tension and perturbations from the pathways by aberrant appearance and/or mutation (Schulte and Neckers, 1998; Xiao et al., 1999). Inhibition of Hsp90 chaperone activity leads to activation of temperature shock aspect-1 (HSF-1) and following activation of defensive stress-induced HSPs such as for example Hsp70 (Dickey et al., 2005; Fujikake et al., 2008). Geldanamycin (GA), a taking place Hsp90 inhibitor normally, has been present to up-regulate Hsp70 and it is cytoprotective in lots of assays of misfolded protein-related toxicity (McLean et al., 2004; Fujikake et al., 2008). GA itself cannot combination the blood-brain hurdle and has significant toxicity in tumor studies (Waza et al., 2006; Fujikake et al., 2008). 17-(Allylamino)-17-demethoxygeldanamycin (17-AAG) and 17-dimethylaminoethylamino-17-demethoxy-geldanamycin (17-DMAG) are significantly less poisonous derivatives of GA that are blood-brain hurdle permeable (Waza et al., 2006; Fujikake et al., 2008), however they have been challenging to formulate, possess limited dental availability, or trigger varying levels of hepatotoxicity in scientific cancer studies, presumably due to the reactivity from the chemical substance primary (Chiosis and Tao, 2006; Cysyk et al., 2006; Okawa et al., 2009). SNX-2112 represents a course of novel, available orally, reactive nonchemically, and powerful Hsp90 inhibitors that display exceptional antitumor activity in vitro and in vivo (Chandarlapaty et al., 2008; Okawa et al., 2009). In this scholarly study, we screened several synthetic, active orally, small-molecule Hsp90 inhibitor substances in this medication class within an in vitro style of syn oligomerization and toxicity as well as for human brain penetration. These materials are dissimilar to GA and derivatives chemically. We present that book Hsp90 inhibitors can recovery syn-induced toxicity and reduce oligomerization in vitro within a dose-dependent way at a lesser dosage than 17-AAG. In vivo pharmacokinetic (PK) and pharmacodynamic research also reveal that members of the course Vadadustat of Hsp90 inhibitors possess good human brain absorption and exceptional oral bioavailability, producing them good candidates for even more evaluation thus. Jointly, these data offer important preclinical details that validates inhibition of Hsp90 as a solid therapeutic technique in Parkinson’s disease and various other neurodegenerative disorders associated with protein misfolding. Components and Strategies Plasmids Syn-Luc1 (S1) and Syn-Luc2 (S2) had been generated, as referred to previously (Outeiro et al., 2008), by subcloning syn in to the Not really1/ClaI sites of humanized luciferase constructs supplied by Dr. Stephen Michnick from the College or university of Montreal (Remy and Michnick, 2006). The Hsp70 and wild-type syn (pSI-WTsyn) plasmids found in this research have been referred to previously (Klucken et al., 2004). Full-length luciferase cDNA was supplied by Dr. Bakhos Tannous from the Massachusetts General Medical center (Tannous et al., 2005). Cell Lifestyle and Transfection Individual H4 neuroglioma cells (HTB-148; American Type Lifestyle Collection, Manassas, VA) had been taken care of in OPTI-MEM development mass media with 10% fetal bovine serum (both from Invitrogen, Carlsbad, CA) and incubated at 37C in 5% CO2 circumstances. H4 cells had been plated to 80 to 90% confluence 16 to 24 h before Vadadustat transfection. These were transfected by usage of Superfect (QIAGEN, Chatsworth, CA) based on the manufacturer’s process. Equimolar plasmid ratios for everyone constructs were utilized. Toxicity Assay Toxicity was assessed 24 h after transfection by usage of the Toxilight cytotoxicity assay Rabbit Polyclonal to AIBP package (Lonza, Rockland, Me personally) based on the manufacturer’s guidelines. Luciferase Protein Complementation Assay H4 neuroglioma cells were Vadadustat cotransfected with S2 and S1 in 96-good plates seeing that described over. At 24 h after transfection, existing cell mass media were changed with serum-free, phenol red-free Opti-MEM (Invitrogen). The cell-permeable substrate, indigenous Coelenterazine (Prolume Ltd, Pinetop, AZ) was resuspended in methanol to at least one 1 mg/ml and dispensed per well by an computerized dish audience, the Wallac 1420 Victor2 (PerkinElmer Lifestyle and Analytical Sciences, Waltham, MA) to your final focus of 20 M. The sign produced from substrate-enzyme relationship was included over 2.", "domain": "chemistry", "round": 3} +{"url": "https://repositories.lib.utexas.edu/handle/2152/75105", "date": "2019-11-16T23:54:03Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-47/segments/1573496668772.53/warc/CC-MAIN-20191116231644-20191117015644-00072.warc.gz", "language_score": 0.8885126709938049, "token_count": 675, "dump": "CC-MAIN-2019-47", "global_id": "webtext-fineweb__CC-MAIN-2019-47__0__204614850", "lang": "en", "text": "Fluid inclusion constraints on the hydrothermal processes responsible for Cu-Au mineralization in the Ertsberg East Skarn System, Papua, Indonesia\nMetadataShow full item record\nThe Ertsberg East Skarn System (EESS) is a 3-Gt orebody at 0.59% Cu and 0.49 ppm Au that extends from the surface at 4200m at least to 1800m elevation. Skarn-hosted Cu-Au ores are localized in Upper Cretaceous siliciclastic to Lower Paleogene carbonate strata along the steeply dipping contact with the 3-Ma Ertsberg Diorite that locally hosts stockwork ores. Petrography, quartz SEM-Cathodoluminesence (SEM-CL), fluid inclusion microthermometry, and fluid inclusion LA-ICP-MS were used to characterize vein formation and fluid conditions in the ore-forming system. Five vein-hosting lithologies and five stages of vein formation were defined petrographically, and 41 SEM-CL transects from 17 quartz vein samples were used to identify eight recurring quartz CL textures that vary by elevation and host lithology. The CL texture paragenesis reveals quartz-sulfide vein architecture rife with brittle deformation features and evidence of repeated opening and mineralization of fractures. Brittle deformation increased with depth in diorite-hosted veins and was most prevalent in skarn-hosted veins. Fluid inclusion petrography of 16 samples, in-situ micro-thermometry of 107 fluid inclusions in eight samples, and LA-ICP-MS of 99 inclusions revealed four types of inclusions consistent with Cu-Au porphyry systems. Type 1 inclusions are 4-11% salinity, 40-70 vol% vapor bubble, homogenize between 332-396 C and can contain chalcopyrite daughter crystals. Type 2a inclusions are 27-51% salinity, 10-30 vol% vapor bubble, homogenize between 280-420 C and contain halite. Type 2a inclusions may also contain sylvite, anhydrite, chalcopyrite, magnetite, and hematite. Type 2b inclusions are 1-12% salinity, 65-90 vol% vapor bubble, homogenize between 340-392 C and typically do not contain daughter minerals. Type 3 inclusions at ambient conditions are 2-23% salinity, 15-50 vol% vapor bubble, homogenize between 283-403C and may contain opaque minerals. LA-ICP-MS analysis indicate that EESS fluid inclusions have high Na, K, and Ca, and support mineralization by Cu, Fe, Mn, Pb and Zn-rich brine derived from phase separation of a primary magmatic fluid. All fluid inclusion types were observed over the 1.7 km of elevation sampled – nearly 4x the vertical extent documented for other porphyry systems. The upper limit of the phase separation zone is present at ~2500 m, which corresponds with deepest known Cu-Au concentrations. These data support fault-controlled fluid migration and a lack of lithologic control on Cu-Au mineralization in veins.", "domain": "chemistry", "round": 3} +{"url": "http://www.vokna.info/download/antibody-mediated-drug-delivery-systems-concepts-technology-and-applications", "date": "2018-12-11T21:17:23Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-51/segments/1544376823702.46/warc/CC-MAIN-20181211194359-20181211215859-00537.warc.gz", "language_score": 0.6560457944869995, "token_count": 555, "dump": "CC-MAIN-2018-51", "global_id": "webtext-fineweb__CC-MAIN-2018-51__0__160918444", "lang": "en", "text": "By Yashwant Pathak,Simon Benita\nRead Online or Download Antibody-Mediated Drug Delivery Systems: Concepts, Technology, and Applications PDF\nSimilar organic chemistry books\nThe volumes of this vintage sequence, now pointed out easily as \"Zechmeister” after its founder, L. Zechmeister, have seemed lower than the Springer Imprint ever because the sequence’ inauguration in 1938. The volumes comprise contributions on a variety of themes regarding the beginning, distribution, chemistry, synthesis, biochemistry, functionality or use of assorted sessions of evidently taking place ingredients starting from small molecules to biopolymers.\nAlle gangigen mikrobiologischen Nachweismethoden sind hier fur den Praktiker zusammengestellt. Sie werden mit Hilfe von Flu? diagrammen und Referenzergebnissen leicht nachvollziehbar erklart. Zu jedem Nachweis werden die gesetzlichen Anforderungen und Bewertungsma? stabe erlautert - sowohl auf nationaler wie auf EU-Ebene.\nWithin the tale of N, Hugh S. Gorman analyzes the inspiration of sustainability from a clean perspective—the integration of human actions with the biogeochemical biking of nitrogen—and presents a supportive substitute to learning sustainability throughout the lens of weather swap and the biking of carbon.\nThis sequence is world-renowned because the best compilation of present reports of this substantial box. the world over acclaimed for greater than forty years, The Alkaloids: Chemistry and Biology, based through the overdue Professor R. H. F. Manske, maintains to supply striking insurance of this swiftly increasing box.\n- Food Microstructures: Microscopy, Measurement and Modelling (Woodhead Publishing Series in Food Science, Technology and Nutrition)\n- Mass Spectrometry of Natural Products: Plenary Lectures Presented at the International Mass Spectrometry Symposium on Natural Products, Rehovot, Israel, 28 August - 2 September 1977\n- Physical Properties of Lipids\n- Asymmetric Synthesis in Organophosphorus Chemistry: Synthetic Methods, Catalysis and Applications\n- The Preparatory Manual of Explosives: Radical, Extreme, Experimental, Explosives Chemistry Vol.1: A comprehensive look at a variety of radical explosives that are under investigation\nExtra resources for Antibody-Mediated Drug Delivery Systems: Concepts, Technology, and Applications\nAntibody-Mediated Drug Delivery Systems: Concepts, Technology, and Applications by Yashwant Pathak,Simon Benita", "domain": "chemistry", "round": 3} +{"url": "https://scienceon.kisti.re.kr/srch/selectPORSrchArticle.do?cn=JAKO200425720294599", "date": "2021-03-01T13:27:12Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-10/segments/1614178362513.50/warc/CC-MAIN-20210301121225-20210301151225-00139.warc.gz", "language_score": 0.9571840167045593, "token_count": 380, "dump": "CC-MAIN-2021-10", "global_id": "webtext-fineweb__CC-MAIN-2021-10__0__219714138", "lang": "en", "text": "The effect of shield gas on the weldability, mechanical properties and formability of CO2 laser weld joint in 600MPa grade high strength steel was investigated. Bead on plate welds were made under various welding speed and shield gas. Tensile test was carried out under the load of perpendicular and parallel direction to the weld line, Formability of the joint was evaluated by Erichsen test. As the welding speed increases, the porosity fraction decreases. The porosity fraction in the joint used Ar-$50\\%He$ mixed gas as a shield gas was lower than that of the joint used Ar gas. Hardness at the weld metal of full penetrated joint was nearly equal to that of water quenched raw metal. In a tensile test under a perpendicular load to the weld axis, strength and elongation of joint produced by optimum condition were nearly equal to those of base metal. However, the strength of joint in a tensile test under a parallel load to weld axis was higher than that of raw metal, but the elongation of joint was lower than that of raw metal. Elongation and formability were further increased by the method of using Ar+He mixed gas as a shield gas as compared with Ar gas. Formabilities of joints were recorded ranging from $58\\%\\;to\\;70\\%$ of that of base metal with different shield gases.\nJang, Jin-Young ; Choi, Woo-Nam ; Jung, Byung-Hun ; Kang, Chung-Yun 2009. \"Effect of Welding Speed on Mechanical Properties and Formability in Nd:YAG Laser Welds of 1000MPa Grade DP Steel\" 大韓溶接·接合學會誌 = Journal of the Korean Welding and Joining Society, 27(2): 69~75", "domain": "chemistry", "round": 3} +{"url": "https://www.mysciencework.com/publication/show/energy-coupling-in-the-active-transport-of-amino-acids-by-bacteriohodopsin-containing-cells-of-halobacterium-holobium", "date": "2018-12-11T02:03:21Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-51/segments/1544376823550.42/warc/CC-MAIN-20181211015030-20181211040530-00344.warc.gz", "language_score": 0.9491004943847656, "token_count": 416, "dump": "CC-MAIN-2018-51", "global_id": "webtext-fineweb__CC-MAIN-2018-51__0__16326431", "lang": "en", "text": "Growth of Halobacterium halobium under illumination with limiting aeration induces bacteriorhodopsin formation and renders the cells capable of photophosphorylation. Cells depleted of endogenous reserves by a starvation treatment were used to investigate the means by which energy is coupled to the active transport of [14C]proline, -leucine, and -histidine. Proline was readily accumulated by irradiated cells under anaerobiosis even when the photophosphorylation was abolished by the adenosine triphosphatase inhibitor N,N'-dicyclohexylcarbodimiide (DCCD). The uptake of proline in the dark was limited except when the cells were allowed to accumulate adenosine 5'-triphosphate (ATP) by prior light exposure or by the oxidation of glycerol. DCCD inhibited this dark uptake. These findings essentially support Mitchell's chemiosmotic theory of active transport. The driving force is apparently the proton-motive force developed when protons are extruded from irradiated bacteriorhodopsin or by the dydrolysis of ATP by membrane adenosine triphosphatase. Carbonylcyanide m-chlorophenylhydrazone (CCCP), a proton permeant known to abolish membrane potential, was a strong inhibitor of proline uptake. Leucine transport was also apparently driven by proton-motive force, although its kinetic properties differed from the proline system. Histidine transport is apparently not a chemiosmotic system. Dark- or light-exposed cells show comparable initial rats of histidine uptake, and these processes were only partially inhibited by DCCD or CCCP. The histidine system apparently does not utilize ATP per se since comparable rates of uptake were exhibited by cells of differing intracellular ATP levels. Irradiated cells did effect a greater total accumulation of histidine than dark-exposed cells. These findings suggest that ATP is needed for sustained transport.", "domain": "chemistry", "round": 3} +{"url": "https://scholar.uwindsor.ca/etd/7786/", "date": "2024-02-21T05:24:30Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707947473370.18/warc/CC-MAIN-20240221034447-20240221064447-00119.warc.gz", "language_score": 0.82470703125, "token_count": 363, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__149616614", "lang": "en", "text": "Date of Award\nMechanical, Automotive, and Materials Engineering\nAlternative Fuels, Dimethyl Ether, Direct Injection, Fuel, Spray\nCreative Commons License\nThis work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.\nThe primary objective of this thesis is to analyze the spray characteristics and behaviour of dimethyl ether (DME) in a high-pressure direct injection application. To achieve these results, two optically-accessible constant-volume chambers (CVC) will be used to observe the fuel spray development. An injector is instrumented inside the CVC and the injections are recorded with a high-speed camera. Various injection and background parameters are manipulated to study the effect of each parameter on the fuel spray characteristics and spray behaviour. Two types of experiments are used to study fuel spray, a quantitative study and an observational study. The first uses a direct imaging setup to measure the spray characteristics, e.g. spray penetration length and cone angle. The latter adopts a shadowgraph imaging technique to enhance the visual representations of vaporization around the fuel spray. In the first section of results, only the spray characteristics and vaporization behaviour of DME fuel will be presented and detailed. These will include results from both experiment types, the quantitative study and the observational study. In the second section of results, the corresponding sprays of diesel and n-butanol fuel are analyzed and compared to that of DME fuel. For a thorough comparison of the tested fuels, these experiments are subjected to the same testing parameters as used for DME fuel.\nLeBlanc, Simon, \"Spray Characteristics of Dimethyl Ether in a Direct Injection Application\" (2019). Electronic Theses and Dissertations. 7786.", "domain": "chemistry", "round": 3} +{"url": "http://www.imaps.org/abstracts/system/new/abstract_preview.asp?abstract=09cicmt013", "date": "2018-10-19T07:31:00Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-43/segments/1539583512332.36/warc/CC-MAIN-20181019062113-20181019083613-00110.warc.gz", "language_score": 0.8981389403343201, "token_count": 464, "dump": "CC-MAIN-2018-43", "global_id": "webtext-fineweb__CC-MAIN-2018-43__0__104759715", "lang": "en", "text": "Here is the abstract you requested from the CICMT_2009 technical program page. This is the original abstract submitted by the author. Any changes to the technical content of the final manuscript published by IMAPS or the presentation that is given during the event is done by the author, not IMAPS.\n|Fabrication of High-K Dielectric Nanofilms using Solution-Based Bottom-Up Nanotechnology|\n|Keywords: High-k dielectrics, Bottom-up nanotechnology, Oxide nanosheets|\n|The integration of high permittivity (k) dielectrics into microelectronic devices, combined with the size reduction constraints, is a current challenge in the semiconductor industry. In this study, we demonstrate a novel fabrication procedure for high-k dielectric nanofilms by using of oxide nanosheets as a building block. A variety of oxide nanosheets (such as Ti0.87O2, TiNbO5, Ti2NbO7, Nb3O8 and perovsites) were synthesized by delaminating appropriate layered precursors into their molecular single sheets. These nanosheet only consists of TiO6 and NbO6 octahedra, a key building block of oxide dielectrics, which makes the nanosheet as an ideal base for high-k dielectrics with the critical thickness. Layer-by-layer assembly was employed to fabricate high-k dielectric nanofilms of these nanosheets on atomically-flat Pt or SrRuO3 substrates. High-resolution transmission electron microscopy revealed that these multilayer nanofilms are composed of the well-ordered lamellar structure with an atomically sharp interface. These nanofilms exhibited both high dielectric constant (100~300) and low leakage current density (< 10-7 A/cm2) for thickness down to 5 nm while eliminating problems resulting from the size effect. Our bottom-up approach provides a rational design and construction of high-k devices.|\n|Minoru Osada, Senior Researcher\nNational Institute for Materials Science\nTsukuba, Ibaraki 305-0044,", "domain": "chemistry", "round": 3} +{"url": "https://www.jspb.jp/english/sub04/archive/pb27_3/", "date": "2023-05-29T00:02:15Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-23/segments/1685224644571.22/warc/CC-MAIN-20230528214404-20230529004404-00784.warc.gz", "language_score": 0.8547728061676025, "token_count": 1550, "dump": "CC-MAIN-2023-23", "global_id": "webtext-fineweb__CC-MAIN-2023-23__0__195729211", "lang": "en", "text": "Utilization of plants and microorganisms for environment and energy\nTaku Demura. . . . . . . 221 [PDF]\nMechanisms underlying interspecific variation in photosynthetic capacity across wild plant species\nKouki Hikosaka. . . . . . . 223 [PDF]\nThere is large variation in photosynthetic capacity among vascular plant species. Here I show that various factors are involved in the variation: CO2 diffusion from air to chloroplasts, nitrogen use in the photosynthetic apparatus, and kinetics of rubisco.\nGeneration of nucleotide sugars for biomass formation in plants\nToshihisa Kotake, Chie Hirosawa, Yasutoshi Ando, Yoichi Tsumuraya. . . . . . . 231 [PDF]\nThe levels of nucleotide sugars, as well as the levels of the glycosyltransferases, regulate the production of plant cellulosic biomass. This review focuses on the recent progress in our understanding of the mechanism for the generation of nucleotide sugars through the salvage pathway for free monosaccharides in higher plants.\nTranscriptional regulation of secondary wall formation controlled by NAC domain proteins\nMasatoshi Yamaguchi, Taku Demura. . . . . . . 237 [PDF]\nSecondary wall is found in several types of plant cells, such as xylem vessels and fiber cells. Recent studies reported that some NAC domain transcription factors play pivotal roles in secondary wall formation. In this review, we have summarized the roles of the NAC domain transcription factors.\nHigh-performance lignin-mimetic polyesters\nTatsuo Kaneko, Daisaku Kaneko, Siqian Wang. . . . . . . 243 [PDF]\nLignin-mimetic hyperbranching polyesters were prepared by a copolycondensation of phytomonomers p-coumaric acid and caffeic acid. The polyesters showed very high thermoresistance and in-soil degradability to apply as a degradable plastic with extremely high performance.\nHeterologous expression of diverse barley XTH genes in the yeast Pichia pastoris\nNomchit Kaewthai, Andrew J. Harvey, Maria Hrmova, Harry Brumer, Ines Ezcurra, Tuula T. Teeri, Geoffrey B. Fincher. . . . . . . 251 [PDF]\nHeterologous expression of plant genes, particularly those encoding carbohydrate-active enzymes such as glycoside hydrolases and glycosyl transferases, continues to be a major hurdle in the functional analysis of plant proteomes. Here, we demonstrate the utility of the yeast P. pastoris for the expression of a range of xyloglucan endo-transglycosylase/hydrolase (XTH) cDNAs from barley (Hordeum vulgare), as a precursor to biochemical characterisation. Notably, the 50% success rate obtained is similar to that previously observed for the recombinant production of human proteins in this host.\nCharacterization of α-L-arabinofuranosidase related to the secondary cell walls formation in Arabidopsis thaliana\nHitomi Ichinose, Nobuyuki Nishikubo, Taku Demura, Satoshi Kaneko. . . . . . . 259 [PDF]\nThe xylem vessel formation stage-specific family 51 α-L-arabinofuranosidase (At3g10740) was characterized. The recombinant enzyme preferentially hydrolyzed arabinoxylo-oligosaccharides, suggesting that it is involved in the modification of the structure of xylan together with family 10 xylanases during the xylem vessel formation.\nMYB transcription factors orchestrating the developmental program of xylem vessels in Arabidopsis roots\nYoshimi Nakano, Nobuyuki Nishikubo, Nadia Goue, Misato Ohtani, Masatoshi Yamaguchi, Yoshihiro Katayama, Taku Demura. . . . . . . 267 [PDF]\nWe demonstrated the detailed expression pattern and transcriptional regulatory network of ten Arabidopsis MYB genes, MYB20, 43, 46, 52, 63, 83, 85, 99, 103, and 118, with the up-regulated expression during in vitro vessel element differentiation.\nMolecular cloning of cDNAs encoding two glycoside hydrolase family 7 cellobiohydrolases from the basidiomycete Flammulina velutipes\nMaki Ishiguro, Tomonobu Hori, Takuya Ishida, Makoto Yoshida, Koji Takabatake, Satoshi Kaneko, Kiyohiko Igarashi, Masahiro Samejima. . . . . . . 273 [PDF]\nTwo genes coding glycoside hydrolase (GH) family 7 were cloned from Enokitake mushroom, Flammulina velutipes. Comparison of deduce amino acid sequences indicated that two enzymes have differences at loop region, which may affect the reactivity of substrates, although they have high similarity each other.\nBiochemical characterization of family 43 glycosyltransferases in the Populus xylem: challenges and prospects\nAnders Winzell, Gea Guerriero, Henrik Aspeborg, Yiqiang Wang, Alex S. Rajangam, Tuula T. Teeri, Inés Ezcurra. . . . . . . 283 [PDF]\nWe report different attempts to heterologously express PttGT43A, a xylem-specific family 43 glycosyltransferase (GT) from hybrid aspen which is a putative IRREGULAR XYLEM9 (IRX9) homologue. Transient expression in tobacco leaves using a viral vector produced substantial amounts of protein but only weak xylosyltransferase activity was detected in microsomal extracts. This suggest that transient co- expression in leaves of candidate subunit GTs may provide a viable approach for formation of an active xylan xylosyltransferase enzymatic complex.\nEnhanced solubilization of polygalacturonic acid synthase by ribonuclease treatment of cell homogenates\nMasamichi Uegaki, Kazutoshi Yasui, Takeshi Ishimizu. . . . . . . 289 [PDF]\nPolygalacturonic acid synthase involved in pectin biosynthesis has not been purified due to its instability and its low activity in the solubilized enzyme solution. We report that ribonuclease treatment of cell homogenates during protein extraction enhanced solubilization of the enzyme 2.1-fold.\nTerminally-Catecholized Hyper-Branched Polymers with High Performance Adhesive Characteristics\nDaisaku Kaneko, Shougo Kinugawa, Keitaro Matsumoto, Tatsuo Kaneko. . . . . . . 293 [PDF]\nWe have synthesized novel adhesive polymers from plant-derived monomers. Since these polymers have catechol group at their chain ends, it was found that they showed strong adhesive characteristics to metal surfaces, which were equivalent to conventional superglues.", "domain": "chemistry", "round": 3} +{"url": "https://www.haiqi-energyfromwaste.com/news/polygeneration-carbonization-system/chile-biomass-carbonization-project.html", "date": "2023-10-04T12:34:17Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233511369.62/warc/CC-MAIN-20231004120203-20231004150203-00360.warc.gz", "language_score": 0.9051870107650757, "token_count": 895, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__292733992", "lang": "en", "text": "10/3/2022 · Biomass can be used as thermal energy through direct incineration, 1 it can also be converted into biofuels and value-added chemicals 2 through pyrolysis, 3 gasification, 4 and hydrothermal carbonization (HTC). 5 Among these methods, pyrolysis (500–600 C 6\nJack Tang. CEO & Co-Founder, Urban. “Sourceful Climate allows us to have a permanent impact on our carbon foohaiqint and take differentiating action on climate\". Courtney Scott. Founder, Pitt Balm. “Sourceful Climate enabled us to take the climate action we knew the world needed, but that we didn’t previously know how\". Elinor Pitt.\n1/1/2015 · If the biomass is not further treated by means of slow pyrolysis or carbonization, the stored C within the biomass is rapidly released as CO 2 through biological decay (i.e., rotting)\n1/8/2020 · The experimental procedure detailed herein ashaiqihaiqi different process schemes based on the low-temperature reaction known as hydrothermal carbonization. The performances of two lab-scale reactor configurations, with and without a downstream flash expansion step, were evaluated and compared. Each setup was tested with six different types of\nBeston pyrolysis plant in Botswana is a project to convert waste into usable energy. If customers are interested in this pyrolysis machine project , they can consult us. Beston will help customers to deeply understand the whole process of project\n21/9/2016 · Biomass pyrolysis carbonization is a complex process and has many reaction. It has the following charachaiqistics: 1. Smaller heating rate, typically 30°C / min or less. Experimental studies have shown that with respect to the rapid heating manner, the slow heating manner can improve the yield of carbon by 5.6%. 2.\nAt this point, Beston has produced the carbonization machine to help us solve the problems caused by various wastes. The machine uhaiqi biomass mahaiqials, sewage sludge and sorted MSW as raw mahaiqials. In addition, Beston charcoal manufacturing machine has also introduced haiqi technology which is called one fire with two applications.\nsyngas conversion, hydrogen from biomass via concentrated solar radiation, microbial fermentation of biomass, and hydrogen from gasification of biomass via supercritical fluid extraction. The production of renewable hydrogen from biomass as a renewable resource requires a co-product strategy to compete with\nView Eliezer Reyes, Ph.D.’s profile on LinkedIn, the world’s largest professional community. Eliezer has 6 jobs listed on their profile. See the complete profile on LinkedIn and discover\n18/2/2022 · The project in question is the US$220mn construction of a new cogeneration boiler that would process forest biomass at the Arauco Plant (MAPA) in the center-south Biobío\n26/5/2016 · Carbonization of biomass is a waste treatment technology, we can use wood, sawdust, rice hull,etc as raw mahaiqial to make charcoal from carbonization plant. Model BST-05 BST-10 BST-20 BST-30 Hourly Feeding Capacity 500kg 0.8-1 Ton 1.5-2 Tons 2.5-3 Tons\n29/9/2017 · Biomass Carbonization Machine. As a kind of biomass thermochemical conversion technology, biomass pyrolysis technology refers to the process of cutting raw mahaiqials into smaller pieces through shredder, and then the raw mahaiqials will be conveyed to furnace tohave a higher temperature carbonization under the condition of no oxygen environment.\nViñales biomass power plant, Chile. The proposed project activity consists in the installation of a new biomass cogeneration power plant in the Viñales sawmill site. The new cogeneration\nThe manufacturing and supply base has been managed at the biomass center since April 2022. The keyword is “virtuous cycles” The goal is the revival of agriculture and the reduction of plant residues, aiming to convert them into high-quality resources with EM technology.", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/ahnak2-antibody-ab224055.html", "date": "2020-10-22T23:08:14Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-45/segments/1603107880401.35/warc/CC-MAIN-20201022225046-20201023015046-00266.warc.gz", "language_score": 0.7619130611419678, "token_count": 390, "dump": "CC-MAIN-2020-45", "global_id": "webtext-fineweb__CC-MAIN-2020-45__0__66951803", "lang": "en", "text": "Key features and details\n- Rabbit polyclonal to AHNAK2\n- Suitable for: ICC/IF, IHC-P\n- Reacts with: Human\n- Isotype: IgG\nStorage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.\nStorage bufferpH: 7.2\nPreservative: 0.02% Sodium azide\nConstituents: 40% Glycerol (glycerin, glycerine), PBS\nConcentration information loading...\nPurityImmunogen affinity purified\nOur Abpromise guarantee covers the use of ab224055 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\n|ICC/IF||Use a concentration of 0.25 - 2 µg/ml.\nFixation/Permeabilization: PFA/Triton X-100.\n|IHC-P||1/200 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.|\nRelevanceAHNAK2 contains 1 PDZ (DHR) domain. There are 3 named isoforms of AHNAK2 produced by alternative splicing. AHNAK2 is a 600-kDa protein composed of a large number of highly conserved repeat segments. AHNAKs are a class of giant propeller-like proteins that associate with calcium channel proteins of cardiomyocytes and other cells.\n- AHNAK 2 antibody\n- AHNAK nucleoprotein 2 antibody\n- C14orf78 antibody\nab224055 has not yet been referenced specifically in any publications.", "domain": "chemistry", "round": 3} +{"url": "https://garydoublewin.en.made-in-china.com/product/WCJnQEcvauhj/China-Female-Enhancement-PT141-Peptide-for-Sexual-Dysfunction.html", "date": "2018-08-16T10:26:46Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-34/segments/1534221210615.10/warc/CC-MAIN-20180816093631-20180816113631-00323.warc.gz", "language_score": 0.7993810772895813, "token_count": 1099, "dump": "CC-MAIN-2018-34", "global_id": "webtext-fineweb__CC-MAIN-2018-34__0__106216599", "lang": "en", "text": "PT141, CAS 32780-32-8, 32780-32-8 manufacturer / supplier in China, offering Female Enhancement PT141 Peptide for Sexual Dysfunction, Human Hormone Peptide Hg Kig Jin Hyg 191AA 10iu/Vial, Anabolic Anastrozle 99.5% Arimidex Bulk Hormone Powder and so on.\n|Min. Order:||1 gram|\n|Port:||Hong Kong, Hong Kong\n|Transport Package:||100% Safety Delivery|\n|Payment Terms:||T/T, Western Union, Money Gram, BitCoin|\nName : Bremelanotide, PT-141\nSingle Impurity (HPLC):1.0%max\nAmino Acid Composition:About 10% of theoretical\nPeptide Content (N%):80.0% min.\nWater Content(Karl Fischer):6.0%max.\nAcetate Content (HPIC):15.0%max.\nPT-141 10mg (Bremelanotide 10mg):\nPT-141 or Bremelanotide is the generic term for a research peptide being studied for its possible use in helping to improve sexual dysfunction in both men (erectile dysfunction or impotence) and women (sexual arousal disorder). PT-141 was developed from the tanning peptide Melanotan 2, which is a synthetically produced variant of a peptide hormone naturally produced in the body that stimulates melanogenesis that is known as alpha-Melanocyte stimulating hormone. MSH, activates certain melanocortin receptors in the process of exerting its effects. Indeed, MSH also exerts potent influence over lipid metabolism, appetite, and sexual libido. Resultantly, PT-141 has been shown in studies to exhibit libido-enhancing effects by activating the melanocortin receptors MC1R and MC4R, but not skin tanning. Melanotan 1 and Melanotan 2 have been researched for their use in protecting against the harmful effects of ultraviolet radiation from sunlight due to their melanogenesis-stimulating properties.\nPT-141 and Sexual Dysfunction:\nPT-141 is a potential remedy for the treatment of sexual dysfunction; specifically, male erectile dysfunction. Studies have shown that PT-141 does not act on the vascular system like former compounds, but allegedly works by activating melanocortin receptors in the brain, therefore helping increase ones sexual stimulation. PT-141 is a melanocortin based peptide that has shown effectiveness in clinical studies on both male and female rats. Male rats have shown erectile response with doses as low as 1-2 mgs whereas most female rats have shown positive results with higher doses around 2-3 mgs. While the dosage requirements tend to be higher for female rats, the observable results in female rats tend to be stronger.\n|Appearance||White to off white powder||Consistent|\n|Product name||PT141 Acetate|\n|CAS register number||32780-32-8|\n|Amino Acid Composition||±10% of theoretical|\n|Water Content(Karl Fischer)||≤6.0%|\nOur Competitive Advantages:\n1. Rich experience: we specialize in this field for many years, our steroids have been exported almost over the world. Such as USA, Canada, UK, Brazil, Germany, Russia, Australia, Greece, Poland, Bulgaria, Rumania, Netherlands, Sweden, Ukraine, Latvia, Lithuania, Ireland, Austria, Iran, Turkey, Mexico, Thailand, India, Malaysia, Singapore, other Middle East countries, European countries, American countries and more Areas.\n2. Great quality: High purity and Favorable price. Good quality is the first base of our success. All of our products enjoys high purity. Thus, it can make sure your demand. Welcome order the samples, MOQ just 10 grams.\n3. Safe and fast delivery: Lots of different discreet safe packing methods, experience in choosing express, 4~7 days to arrive, successful rate 99%.\n4. Experiential order and cooperation: Besides raw powders, we offer hormone solution and Recipes. We can teach you or discuss how to make hormone solution on the site. Any discussion and question is welcome!\nPackaging & Service:\n1. Mass stock, to make sure delivery promptly every day when the payment is done.\n2. Having been engaged in this field for years, we have sophisticated and professional logistics department, which can guarantee safe and speedy delivery.\n3. Well-trained and disciplined packing team which is professional enough to provide you a safe package. It also avoid a lot of emergency happen during the delivery so that high customs pass is guaranteed. Unique ways to ship 10grams to 20 kilograms powders(or 100ml to 30 Liter liquids) at one time to your destination.\n4. Packing pictures and tacking number are provided within 24 hours as soon as receiving the payment. Updated tracking code will be provided every other day just for you can hold a palm of your package.\n5. Perfect after-sale service: Any questions or problems happened after receiving the product.\nPlease feel free to contact us. 24/7 online to solve your various problems!", "domain": "chemistry", "round": 3} +{"url": "http://tam-receptor.com/2019/05/15/ros-reactive-oxygen-species-from-mitochondrial-and-non-mitochondrial-sources-have-been/", "date": "2023-04-02T09:37:14Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-14/segments/1679296950422.77/warc/CC-MAIN-20230402074255-20230402104255-00679.warc.gz", "language_score": 0.9048522114753723, "token_count": 1284, "dump": "CC-MAIN-2023-14", "global_id": "webtext-fineweb__CC-MAIN-2023-14__0__239315463", "lang": "en", "text": "ROS (reactive oxygen species) from mitochondrial and non-mitochondrial sources have been implicated in TNF (tumour necrosis factor )-mediated signalling. TNF caused maximal nuclear translocation of NF-B within 15?min, compared with 1?h in cells pretreated with MitoVit E. Thus the accumulation of an antioxidant within the mitochondrial matrix enhances TNF-induced apoptosis by decreasing or delaying the expression of the protective antiapoptotic proteins. These results demonstrate that mitochondrial ROS production is a physiologically relevant component of Lenvatinib manufacturer the TNF signal-transduction pathway during apoptosis, and reveal Igfbp5 a novel functional role for mitochondrial ROS as a temporal regulator of NF-B activation and NF-B-dependent antiapoptotic signalling. release, than a complete upsurge in mobile ROS amounts [17 rather,18]. Furthermore, it isn’t possible to measure localized subcellular adjustments in ROS creation currently. In light from the uncertainties elevated by these total outcomes, we have Lenvatinib manufacturer tackled the specific part of mitochondrial ROS and oxidative harm in TNF-induced apoptosis using mitochondria-targeted derivatives of supplement E MitoVit E; [2-(3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)ethyl]triphenylphosphonium bromide, ubiquinol (MitoQ, an assortment of mito-quinol [10-(3,6-dihydroxy-4,5-dimethoxy-2-methylphenyl)decyl]triphenylphosphonium bromide and mito-quinone [10-(4,5-dimethoxy-2-methyl-3, 6-dioxo-1, 4-cyclohexadien-1-yl) decyl]triphenylphosphonium bromide) and PBN MitoPBN; [4-[4-[[(1,1-dimethylethyl)oxidoimino]methyl]phenoxy]butyl]triphenylphosphonium bromide These targeted antioxidants, MitoVit E, MitoPBN and MitoQ, accumulate in the mitochondrial matrix safeguarding mitochondria against oxidative harm [19 selectively,20]. MitoVit and MitoQ E protect cells from a number of apoptotic stimuli, including 5-fluorouracil , development element deprivation glutathione and depletion in frataxin-depleted cells , and in addition inhibit H2O2-induced development element receptor signalling . These results have confirmed that mitochondrial ROS have a role in these processes and demonstrate that the mitochondria-targeted antioxidants are useful tools for determining the role of mitochondrial ROS in signal transduction. In the present study, we found that mitochondrial ROS were critical modulators of TNF-induced apoptosis and that this was mediated at least in part by a delay in the activation of NF-B (nuclear factor B). This suggests that mitochondrial ROS are produced in response to TNF treatment, and these ROS prevent a full apoptotic response to TNF by enhancing NF-B-mediated expression of antiapoptotic proteins. EXPERIMENTAL Cells and reagents The human monocytic cell line U937 and the human T cell line Jurkat were maintained in RPMI 1640, supplemented with 10% (v/v) foetal bovine serum, 1% glutamine, 100?units/ml penicillin and 100?g/ml streptomycin. Recombinant hTNF (human TNF) was obtained from R & D Systems (Abingdon, Oxfordshire, U.K.) and annexin VCFITC (FITC-conjugated annexin V) was from Molecular Probes (Eugene, OR, U.S.A.). Anti-cytochrome antibody (clone 7H8.2C12) was from Pharmingen (San Diego, CA, U.S.A.) and anti-Bid polyclonal antibody was from BioVision (Mountain View, CA, U.S.A.). Secondary antibodies were from Bio-Rad Laboratories (Hemel Hempstead, Herts., U.K.). The caspase 3 [Ac-DEVD-AMC (release, U937 cells were seeded at 2106 cells/ml in a Lenvatinib manufacturer 12-well plate (1?ml/well) and incubated overnight. Cells were preincubated in the presence or absence of MitoVit E for 30?min before the addition of 5?ng/ml hTNF. After various time periods, the cells were harvested, washed and resuspended in 50?l of STE buffer (0.25?M sucrose, 5?mM Tris and 1?mM EGTA), supplemented with Complete? EDTA-free protease inhibitor tablets (Roche Diagnostics, Auckland, New Zealand). Digitonin was added to give 30?g/mg of protein and, after a 15?min incubation on ice, the samples were microfuged for 5?min. The supernatant (cytosolic fraction) was precipitated with acetone and resuspended in SDS/PAGE sample buffer for analysis. For analysis of Bid cleavage, cells were treated and seeded while described Lenvatinib manufacturer over and entire cell lysates were prepared using RIPA buffer [50?mM Tris, pH?7.4, 1% NP40 (Nonidet P40), 0.25% sodium deoxycholate, 150?mM NaCl and 1?mM EGTA], supplemented with Complete? EDTA-free protease inhibitor tablets. Protein had been separated by SDS/Web page (15% polyacrylamide), used in a nitrocellulose membrane, clogged with 5% dairy powder in.", "domain": "chemistry", "round": 3} +{"url": "http://www.antibodies-online.com/fc-epsilon-receptor-signaling-pathway-pathway-22/lat2-elisa-kit-3992/", "date": "2018-01-21T20:36:45Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-05/segments/1516084890874.84/warc/CC-MAIN-20180121195145-20180121215145-00404.warc.gz", "language_score": 0.8516474962234497, "token_count": 1255, "dump": "CC-MAIN-2018-05", "global_id": "webtext-fineweb__CC-MAIN-2018-05__0__210995019", "lang": "en", "text": "Use your antibodies-online credentials, if available.\nNo Products on your Comparison List.\nYour basket is empty.\nFind out more\nShow all species\nShow all synonyms\nSelect your species\nLAT1 (show LAT ELISA Kits) and LAT2 were overexpressed in both pheochromocytoma and medullary thyroid carcinoma by comparison with normal tissues.\nThe detergent-induced stabilization of the purified human 4F2hc (show SLC3A2 ELISA Kits)-LAT2 complex presented here paves the way towards its crystallization and structure determination at high-resolution\nThe AML1 (show RUNX1 ELISA Kits)/ETO (show RUNX1T1 ELISA Kits) target gene LAT2 interferes with differentiation of normal hematopoietic precursor cells.\nLAT2 is an early mediator of the anti-leukemic activity of alkylphospholipids and arsenic trioxide. Thus, LAT2 may be used as a target for the design of drugs for cancer therapy.\nNTAL acts as a tumor suppressor that enhances the proximal signaling of leukemic blasts. The key downstream molecule responsible for the biological effect of TCR signaling is ERK (show EPHB2 ELISA Kits).\nLAT2 protein (NTAL) participates in the activation of the c-Met-Grb2 (show GRB2 ELISA Kits)-ERK (show EPHB2 ELISA Kits)-cPLA2 (show PLA2G4A ELISA Kits) signalling cascade at early stages of H. pylori infection.\ndata show that NTAL (non-T cell activation linker) appears to be a structural and possibly also functional homologue of LAT (linker for activation of T cells (show LAT ELISA Kits))in non-T cells [non-T cell activation linker]\nLAB links BCR (show BCR ELISA Kits) engagement to downstream signaling pathways.\nLAB was primarily phosphorylated on three membrane-distal tyrosines, Tyr (show TYR ELISA Kits)(136), Tyr (show TYR ELISA Kits)(193), and Tyr (show TYR ELISA Kits)(233). Mutation of these three tyrosines abolished Grb2 (show GRB2 ELISA Kits) binding and LAB function\nLAB resembled a LAT (show ORC3 ELISA Kits) molecule unable to bind phospholipase C (show PLC ELISA Kits)-gamma1.\nNTAL is a negative regulator of FcepsilonRI (show FCER1A ELISA Kits) activation events in murine bone marrow-derived mast cells, independently of possible compensatory developmental alterations.\nCerebral cortex hyperthyroidism of newborn mct8 (show MCT8 ELISA Kits)-deficient mice transiently suppressed by lat2 (show SLC7A8 ELISA Kits) inactivation.\nOur data define a novel link between LAB and beta-catenin (show CTNNB1 ELISA Kits) nuclear accumulation in dendritic cells that facilitates IFN-gamma (show IFNG ELISA Kits) responses during anti-fungal immunity\nchemotaxis toward antigen is controlled in mast cells by a cross-talk among FcepsilonRI, tetraspanin CD9, transmembrane adaptor proteins NTAL and LAT, and cytoskeleton-regulatory proteins of the ERM family\nDihydrotestosterone treatment increased the expression of LAT2 (show SLC7A8 ELISA Kits).\nThe expression of Mct8 (show MCT8 ELISA Kits) and L-type amino acid transporters Lat2 (show SLC7A8 ELISA Kits) and Lat1 (show SLC7A5 ELISA Kits) are determined in brain neurons during development.\na crucial role of NTAL in signaling, via RhoA (show RHOA ELISA Kits), to mast cell cytoskeleton.\nWhile SLP-76 (show LCP2 ELISA Kits) and LAT1 (show SLC7A5 ELISA Kits) depend on each other for many of their functions, LAT2 (show SLC7A8 ELISA Kits)/SLP-76 (show LCP2 ELISA Kits) interactions and SLP-76 (show LCP2 ELISA Kits)-independent LAT1 (show SLC7A5 ELISA Kits) functions also mediate a positive signaling pathway downstream of FcepsilonRI (show FCER1A ELISA Kits) in mast cells.\nLAB is a critical, LAT (show LAT ELISA Kits)-independent regulator of TREM-2 (show TREM2 ELISA Kits) signaling and macrophage development capable of controlling subsequent inflammatory responses\nNTAL negatively regulates Fc-epsilon receptor I-mediated signaling events in bone marrow-derived mast cells.\nThis gene is one of the contiguous genes at 7q11.23 commonly deleted in Williams syndrome, a multisystem developmental disorder. This gene consists of at least 14 exons, and its alternative splicing generates 3 transcript variants, all encoding the same protein.\nWilliams-Beuren syndrome chromosomal region 15 protein\n, Williams-Beuren syndrome chromosomal region 5 protein\n, linker for activation of B-cells\n, linker for activation of T cells, transmembrane adaptor 2\n, linker for activation of T-cells family member 2\n, membrane-associated adapter molecule\n, non-T-cell activation linker\n, Williams-Beuren syndrome chromosome region 5 homolog\n, non-T cell activation linker\n, linker for activation of T cells family, member 2\n, L-type amino acid transporter subunit\n, Williams-Beuren syndrome chromosome region 5-like protein\n, Williams-Beuren syndrome chromosome region 15 homolog\n, williams-Beuren syndrome chromosomal region 15 protein homolog", "domain": "chemistry", "round": 3} +{"url": "https://www.wise-geek.com/how-do-antacids-work.htm", "date": "2022-08-09T20:53:41Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571086.77/warc/CC-MAIN-20220809185452-20220809215452-00083.warc.gz", "language_score": 0.8882063627243042, "token_count": 467, "dump": "CC-MAIN-2022-33", "global_id": "webtext-fineweb__CC-MAIN-2022-33__0__162193567", "lang": "en", "text": "Antacids increase the pH level in the stomach to reduce the heartburn, indigestion and acid reflux associated with an acidic stomach. There are four main antacid types used to raise pH levels. Although safe, the main ingredient used in each type of antacid can cause health problems for people with high blood pressure, kidney issues or bone disease. Using this remedy sparingly will ensure a person suffering from an acidic stomach will not incur additional health problems or stomach issues.\nA sodium-based antacid uses sodium bicarbonate to neutralize stomach acid. The sodium used in this type of antacid neutralizes acid quickly but increases blood pressure and should be avoided by people with high blood pressure or a heart condition. High blood pressure-prone people should consult with a physician before taking any over-the-counter sodium-based antacids. Three other ingredients are used that are safe for people with high blood pressure, but can cause other potentially dangerous health problems if used excessively.\nCalcium-based antacids are safe for use by people with high blood pressure but can have adverse affects for people prone to kidney stones or people that suffer with constipation issues. Either calcium carbonate or calcium phosphate provides the neutralizing power for calcium-based antacids. Both are equally effective in neutralizing stomach acid; in large doses or with frequent use, the calcium will cause kidney stones or constipation when used regularly over a shorter time span. In extreme cases, the calcium can clog the kidneys to the point that blood cannot circulate correctly, which may cause the kidneys to shut down. Another type of antacid safe for high blood pressure uses a different ingredient that affects a person's kidneys and bones.\nAluminum-based antacids also cause kidney stones and constipation but have additional side effects that can weaken bones and cause vital nutrients to leave the taker's body. Unlike antacid types, aluminum-based antacids have shown to be safe for individuals with normal kidney function unless the aluminum-based antacid contains magnesium salts. This combination can cause blood pressure to drop, so people with low blood pressure should avoid this combination in an antacid. All antacid types containing aluminum should be avoided by people suffering from osteoporosis, as the aluminum removes calcium from their bodies.", "domain": "chemistry", "round": 3} +{"url": "https://www.bradigans.com/petroleum-products/valvtect-2/", "date": "2023-12-07T16:41:25Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100677.45/warc/CC-MAIN-20231207153748-20231207183748-00518.warc.gz", "language_score": 0.8033581972122192, "token_count": 300, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__262998519", "lang": "en", "text": "Valvtect Additives & Marine Gasoline and Diesel\nValvTect Marine Gasoline is \"specially formulated\" for marine engines and is designed to prevent the problems of ethanol gasoline, such as phase separation, moisture, poor stability and the formation of power-robbing carbon deposits.\nValvTect Marine Gasoline is \"specially formulated\" for your marine gasoline engine. It requires no additional fuel additives to protect your engine, eliminating any risk of improper additive use and saves time and money.\nRequest ValvTect Information\n- Increases cetane up to 6.5 numbers.\n- Exceeds Cummins L-10 Superior rating (10 CRC max).\n- Cleans up injector deposits.\n- Reduces piston and combustion chamber deposits.\n- Helps prevent rust & corrosion.\n- VT-101 lubricates injectors and pumps and prevents premature wear.\n- Helps improve thermal and storage stability beyond industry standards.\n- Helps prevent sludge.\n- Increases filter life.\n- Increases power.\n- Improves heavy duty fuel economy up to 7.6%*.\n- Fuel economy documented in TMC recommended SAE (Type II test procedure.)\n- Extends injector life.\n- Helps reduce smoke and particulate.\n- Helps reduce exhaust emissions.\n- Absorbs controlled amounts of moisture to help keep tanks dry.\n- Protects against conditions that promote bacteria growth.", "domain": "chemistry", "round": 3} +{"url": "http://wikien4.appspot.com/wiki/Dipalmitoylphosphatidylcholine", "date": "2020-11-28T22:30:04Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-50/segments/1606141195929.39/warc/CC-MAIN-20201128214643-20201129004643-00667.warc.gz", "language_score": 0.7184082269668579, "token_count": 4305, "dump": "CC-MAIN-2020-50", "global_id": "webtext-fineweb__CC-MAIN-2020-50__0__187826867", "lang": "en", "text": "3D modew (JSmow)\nCompTox Dashboard (EPA)\n|Mowar mass||734.053 g·mow−1|\n|4.6 ± 0.5 x 10−10 M|\nExcept where oderwise noted, data are given for materiaws in deir standard state (at 25 °C [77 °F], 100 kPa).\n|what is ?)(|\nIt is de main constituent of puwmonary surfactants, which reduces de work of breading and prevents awveowar cowwapse during breading. It awso pways an important rowe in de study of wiposomes and human biwayers.\nLung surfactant (LS) is a surface-active materiaw produced by most air-breading animaws for de purpose of reducing de surface tension of de water wayer where gas exchange occurs in de wungs, given dat de movements due to inhawation and exhawation may cause damage if dere is not enough energy to sustain awveowar structuraw integrity.\nThe monowayer formed by de LS on de interface is composed primariwy of phosphowipids (80%), in addition to proteins (12%) and neutraw wipids (8%). Among de phosphowipids, de most prevawent one is phosphatidywchowine (PC, or wecidin) (70–85%), which in turn is de basis of a poow of simiwar diacywphophatidywchowines of which 50% is dipawmitoywphosphatidywchowine or DPPC.\nWhiwe DPPC itsewf awready has de abiwity to reduce de surface tension of de awveowar wiqwid, de proteins and oder wipids in de surfactant furder faciwitate de adsorption of oxygen into de air-wiqwid interface.\nDPPC is a variant of phosphatidywchowine. Its structure incwudes bof a hydrophiwic \"head\" and hydrophobic \"taiws\", and it is dis arrangement dat makes it abwe to reduce de surface tension of de water wayer. The chowine radicaw constitutes de powar hydrophiwic head; it is oriented towards and extends into de awveowar wiqwid. The pawmitic acid (C16) chains form de nonpowar hydrophobic taiws; dese are oriented towards de outer side.\nThe syndesis of de phosphowipids contained in puwmonary surfactant takes pwace in de endopwasmic reticuwum of type II pneumocytes. Puwmonary surfactant has bof protein and wipid components. More specificawwy, it has been found dat phosphatidywchowine (PC) is de most abundant phosphowipid (70%–85%), and dat PC is primariwy present as dipawmitoywphosphatidywchowine (DPPC).\nDe novo syndesis of phosphatidywchowine in de wung arises primariwy from cytidine diphosphate-chowine (CDP-chowine). The transformation of CDP-chowine to phosphatidywchowine is effected by chowine phosphate cytidywtransferase. Under certain conditions de enzymes chowine kinase, gwycerow-3-phosphate acywtransferase and phosphatidate phosphatase may pway reguwatory rowes.\nOf de totaw DPPC in de puwmonary surfactant, 45% comes from de novo biosyndesis. The rest is formed by transacywation mechanisms dat exchange pawmitoyw groups for de unsaturated acyw chains of oder rewated diacywphosphatidywchowines. Removaw of de acyw chains from dese rewated compounds produces wysophosphatidywchowine; reacywation wif pawmitoyw-CoA is den faciwitated by wysophosphatidywchowine acywtransferase to form DPPC.\nThis phosphowipid is found in a sowid/gew phase at 37 °C (at de effective temperature of de human body). Its mewting point is around 41.3 °C. Therefore, when de temperature is above 41 °C, DPPC is no wonger found in a gew phase but in a wiqwid one.\nWhen in contact wif siwica surfaces, it has been demonstrated dat DPPC biwayers have different properties depending on de temperature.\nLayer dickness remains de same at 25 °C and at 39 °C. However, when de temperature is furder increased to 55 °C, de DPPC biwayer structure changes significantwy, which causes a decrease in de wayer dickness. The reason for dis trait is dat, in fact, at 55 °C DPPC is found in a disordered wiqwid state, whereas at a wower temperature it is found in a more-ordered gew state.\nTemperature affects de wayer´s roughness too, which starts to change swightwy when temperature is wowered to 25 °C.\nFinawwy, de woad-bearing capacity of de biwayer is higher when de temperature exceeds de phase transition temperature (due to its increased fwuidity). When dis mowecuwe is found in a wiqwid state, where de fwuidity is much higher, it is dought dat de biwayer awso devewops a sewf-heawing capacity.\nDPPC is an amphipadic wipid. This characteristic is due to its hydrophiwic head, composed of de powar phosphatidywchowine group, and its hydrophobic taiws, formed by two nonpowar pawmitic acid (C16) chains. This trait awwows DPPC to easiwy and spontaneouswy form micewwes, monowayers, biwayers and wiposomes when it is in contact wif a powar sowvent.\nDPPC is de main phosphowipid of puwmonary surfactant, and it is surface-active due to its amphipadic behaviour and its adsorption capacity. However, adsorption is not optimaw at human body temperature for DPPC awone, because at 37 °C it is found in a gew phase. The presence of some unsaturated phosphowipids (such as dioweoywphosphatidywchowine [DOPC] or phosphatidywgwycerow) and chowesterow increases de surfactant's fwuidity, so it can adsorb oxygen more efficientwy. When dis mixture contacts water, for exampwe, it accumuwates at de water-air interface and forms a din superficiaw pewwicuwe of surfactant. The powar heads of de mowecuwes composing de surfactant are attracted by de powar mowecuwes of de wiqwid (in dis case, H2O mowecuwes), causing a significant diminution of de water's surface tension, uh-hah-hah-hah.\nDPPC is usuawwy used for research purposes, such as creating wiposomes and biwayers which are invowved in bigger studies. The Langmuir–Bwodgett techniqwe awwows de syndesis of wiposomaw DPPC biwayers. Currentwy, dese wiposomes are used in de study of de properties of dis phosphatidywchowine and of its use as a mechanism of drug dewivery in de human body.\nFurdermore, because vesicwe fusion dynamics are different for wipids in de gew phase versus de fwuid phase, it awwows scientists to use DPPC awong wif DOPC in Atomic Force Microscopy and Atomic Force Spectroscopy.\nDipawmitoywphosphatidywchowine (DPPC) is routinewy used to formuwate some medicines used for treatment of respiratory distress syndrome (RDS) in newborns. Current syndetic surfactants are combinations of DPPC awong wif oder phosphowipids, neutraw wipids and wipoproteins.\nThe treatment of preterm infants wif RDS using surfactants was initiawwy devewoped in de 1960s, and recent studies have demonstrated an improvement in cwinicaw outcomes. The first treatment given to some newborns wif RDS was surfactant phosphowipids, specificawwy DPPC, by means of an aerosow (Robiwward, 1964).[fuww citation needed] However, dis treatment proved ineffective because administration of DPPC awone did not provide any beneficiaw effects. Subseqwentwy, various studies were carried out to try to find more effective drugs for de treatment of dis disease.\nPuwmonary surfactants can be cwassified into dree types:\nThe second generation of surfactants were of naturaw (animaw) origin, and were obtained from de wungs of cattwe or pigs. The surfactants extracted from bovine wungs were Infasurf and Awvofact, de porcine wung extracts incwuded Curosurf, and dose made from modified bovine wung extracts incwuded Survanta or Beraksurf (Beractant). Unwike newborns wif RDS dat were administered first-generation drugs, dose dat were treated wif dese second-generation surfactants reqwired wess oxygen and ventiwatory support widin 72 hours of drug administration, uh-hah-hah-hah.\nThe dird generation of surfactants incorporates syndetic peptides or recombinant proteins. These use a mixture of different components. DPPC is de agent used to decrease surface tension, and de rest of de components hewp increase oxygen adsorption, uh-hah-hah-hah. The best known are Venicute and Surfaxin, uh-hah-hah-hah. These drugs are stiww under devewopment, so dere is as yet no evidence as to wheder dey possess advantages compared to de second-generation preparations.\nSurfactant Dysfunction Disorder is a disease dat affects newborn chiwdren whose puwmonary surfactant is insufficient for adeqwate breading, resuwting in respiratory distress syndrome (RDS).\nDespite DPPC being one of de major components of wung surfactant, most of de genetic errors dat are winked wif surfactant dysfunction disorder are not winked to DPPC. Rader, de main causes of dis disease are differences in de production of surfactant proteins B and C due to genetic abnormawities.\nHowever, dere is a genetic condition dat is rewated to DPPC which causes a deficiency in de production of ABCA1 protein. This protein is cruciaw in de transport of phosphowipids – and derefore DPPC – to de wamewwar bodies of de awveowar cewws, where DPPC interacts wif surfactant proteins to form puwmonary surfactant.\nCurrent studies cannot find a correwation between de percentage of DPPC in wung surfactant and de age of gestation, awdough a proven rewationship has been found between de percentage of DPPC and POPC (pawmitoyw-oweoyw phosphatidywchowine) in babies wif respiratory distress syndrome compared wif babies widout dis condition, uh-hah-hah-hah. These connections suggest dat a particuwar surfactant composition wiww wead to respiratory distress syndrome, regardwess of gestationaw age.\nThe correwation between DPPC percentage and respiratory distress syndrome is why DPPC is used to make drugs to treat newborn infants wif de disease.\nIn addition, DPPC has been shown to be rewated to infection of powarized cewws by a specific kind of human adenovirus (HAdV-C2). Some studies have indicated dat disaturated DPPC boosts infection of A59 cewws wif HAdV-C2 (possibwy by permitting virus entry via de apicaw side of powarized cewws).\n- Smif, Ross; Tanford, Charwes (June 1972). \"The criticaw micewwe concentration of w-α-dipawmitoywphosphatidywchowine in water and water/medanow sowutions\". Journaw of Mowecuwar Biowogy. 67 (1): 75–83. doi:10.1016/0022-2836(72)90387-7. PMID 5042465.\n- Stachowicz-Kuśnierz, Anna; Seidwer, Tomasz; Rogawska, Ewa; Korchowiec, Jacek; Korchowiec, Beata (2020-02-01). \"Lung surfactant monowayer – A good naturaw barrier against dibenzo-p-dioxins\". Chemosphere. 240: 124850. doi:10.1016/j.chemosphere.2019.124850. ISSN 0045-6535. PMID 31561163.\n- Fernández Ruano, D. Miguew Luis (2000). Caracterización dew compwejo surfactante puwmonar: Estudio de wa estructura y función de wa proteína A (SP-A) (PDF). Madrid: Universidad Compwutense de Madrid. pp. 10–11.\n- \"Dipawmitoywphosphatidywchowine - an overview | ScienceDirect Topics\". www.sciencedirect.com. Retrieved 2019-10-25.\n- Wang, Min; Zander, Thomas; Liu, Xiaoyan; Liu, Chao; Raj, Akanksha; Fworian Wiewand, D. C.; Garamus, Vasiw M.; Wiwwumeit-Römer, Regine; Cwaesson, Per Martin; Dėdinaitė, Andra (2015-05-01). \"The effect of temperature on supported dipawmitoywphosphatidywchowine (DPPC) biwayers: Structure and wubrication performance\". Journaw of Cowwoid and Interface Science. 445: 84–92. Bibcode:2015JCIS..445...84W. doi:10.1016/j.jcis.2014.12.042. ISSN 0021-9797. PMID 25596372.\n- Bai, Xuan; Xu, Lu; Tang, Jenny Y.; Zuo, Yi Y.; Hu, Guoqing (2019-10-01). \"Adsorption of Phosphowipids at de Air–Water Surface\". Biophysicaw Journaw. 117 (7): 1224–1233. Bibcode:2019BpJ...117.1224B. doi:10.1016/j.bpj.2019.08.022. ISSN 1542-0086. PMC 6818144. PMID 31519299.\n- Jackson, J. Craig (2012-01-01), Gweason, Christine A.; Devaskar, Sherin U. (eds.), \"Chapter 46 - Respiratory Distress in de Preterm Infant\", Avery's Diseases of de Newborn (Ninf Edition), W.B. Saunders, pp. 633–646, ISBN 9781437701340, retrieved 2019-10-25\n- Panzuewa, S.; Tieweman, D. P.; Mederos, L.; Vewasco, E. (2019-10-22). \"Mowecuwar Ordering in Lipid Monowayers: An Atomistic Simuwation\". Langmuir. 35 (42): 13782–13790. arXiv:1903.06659. Bibcode:2019arXiv190306659P. doi:10.1021/acs.wangmuir.9b02635. ISSN 0743-7463. PMID 31553617. S2CID 119061661.\n- Attwood, Simon J.; Choi, Youngjik; Leonenko, Zoya (2013-02-06). \"Preparation of DOPC and DPPC Supported Pwanar Lipid Biwayers for Atomic Force Microscopy and Atomic Force Spectroscopy\". Internationaw Journaw of Mowecuwar Sciences. 14 (2): 3514–3539. doi:10.3390/ijms14023514. ISSN 1422-0067. PMC 3588056. PMID 23389046.\n- Adenstaedt, K. (2010). \"Neutraw Lipids in Yeast: Syndesis, Storage and Degradation\". Handbook of Hydrocarbon and Lipid Microbiowogy. pp. 471–480. doi:10.1007/978-3-540-77587-4_35. ISBN 978-3-540-77584-3.\n- Soww, Roger; Ozek, Eren (2010-01-20). \"Prophywactic protein free syndetic surfactant for preventing morbidity and mortawity in preterm infants\". The Cochrane Database of Systematic Reviews (1): CD001079. doi:10.1002/14651858.CD001079.pub2. ISSN 1469-493X. PMC 7059181. PMID 20091513.\n- Chattás, Lic. Guiwwermina (October 2013). \"Administración de surfactante exógeno\" (PDF). Revista Enfermería Neonataw. Nº 16: 10–17 – via Fundasamin, uh-hah-hah-hah.\n- Li, Jing; Wang, Xuwing; Zhang, Ting; Wang, Chunwing; Huang, Zhenjun; Luo, Xiang; Deng, Yihui (2015). \"A review on phosphowipids and deir main appwications in drug dewivery systems\". Asian Journaw of Pharmaceuticaw Sciences. 10 (2): 81–98. doi:10.1016/j.ajps.2014.09.004.\n- Reference, Genetics Home. \"Surfactant dysfunction\". Genetics Home Reference. Retrieved 2019-10-24.\n- Reference, Genetics Home. \"ABCA3 gene\". Genetics Home Reference. Retrieved 2019-10-24.\n- Ashton, M. R.; Postwe, A. D.; Haww, M. A.; Smif, S. L.; Kewwy, F. J.; Normand, I. C. (Apriw 1992). \"Phosphatidywchowine composition of endotracheaw tube aspirates of neonates and subseqwent respiratory disease\". Archives of Disease in Chiwdhood. 67 (4 Spec No): 378–382. doi:10.1136/adc.67.4_spec_no.378. ISSN 1468-2044. PMC 1590480. PMID 1586174.\n- Luisoni, Stefania; Greber, Urs F. (2016-01-01), Curiew, David T. (ed.), \"2 - Biowogy of Adenovirus Ceww Entry: Receptors, Padways, Mechanisms\", Adenoviraw Vectors for Gene Therapy (Second Edition), Academic Press, pp. 27–58, ISBN 9780128002766, retrieved 2019-10-25", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/polr3e-antibody-ab134560.html", "date": "2020-04-03T10:09:43Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-16/segments/1585370510846.12/warc/CC-MAIN-20200403092656-20200403122656-00323.warc.gz", "language_score": 0.7460668683052063, "token_count": 643, "dump": "CC-MAIN-2020-16", "global_id": "webtext-fineweb__CC-MAIN-2020-16__0__145750044", "lang": "en", "text": "Product nameAnti-POLR3E antibody\nSee all POLR3E primary antibodies\nDescriptionRabbit polyclonal to POLR3E\nTested applicationsSuitable for: WB, IPmore details\nSpecies reactivityReacts with: Human\nPredicted to work with: Chimpanzee, Gorilla\nSynthetic peptide, corresponding to a region within amino acids 475-525 of Human POLR3E (NP_060589.1).\n- Whole cell lysate from HeLa, 293T and Jurkat cells\nStorage instructionsShipped at 4°C. Store at +4°C.\nStorage bufferPreservative: 0.09% Sodium azide\nConstituent: 99% Tris citrate/phosphate\npH 7 to 8.\nConcentration information loading...\nPurityImmunogen affinity purified\nOur Abpromise guarantee covers the use of ab134560 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\n|WB||1/2000 - 1/10000. Predicted molecular weight: 80 kDa.|\n|IP||Use at 2-10 µg/mg of lysate.|\nRelevanceDNA dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Essential for efficient transcription from both the type 2 VAI and type 3 U6 RNA polymerase III promoters. There are three isoforms.\n- DNA directed RNA polymerase III 80 kDa polypeptide antibody\n- DNA-directed RNA polymerase III subunit RPC5 antibody\n- FLJ10509 antibody\nAll lanes : Anti-POLR3E antibody (ab134560) at 0.1 µg/ml\nLane 1 : HeLa whole cell lysate at 50 µg\nLane 2 : HeLa whole cell lysate at 15 µg\nLane 3 : 293T whole cell lysate at 50 µg\nLane 4 : Jurkat whole cell lysate at 50 µg\nDeveloped using the ECL technique.\nPredicted band size: 80 kDa\nExposure time: 30 seconds\nDetection of POLR3E by Western Blot of Immunprecipitate.\nImmunoprecipitation of POLR3E in HeLa whole cell lysate, using ab134560 at 6 µg/mg lysate (1 mg/IP; 20% of IP loaded/lane).\nFor the subsequent WB, ab134560 was used at 1 µg/ml.\nThe lysate in lane 2 is precipitated using an IgG control antibody.\nDetection: Chemiluminescence with an exposure time of 10 seconds.\nab134560 has not yet been referenced specifically in any publications.", "domain": "chemistry", "round": 3} +{"url": "http://femirco.ru/melamin-laminat/", "date": "2021-06-15T13:00:07Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-25/segments/1623487621273.31/warc/CC-MAIN-20210615114909-20210615144909-00599.warc.gz", "language_score": 0.9157069325447083, "token_count": 595, "dump": "CC-MAIN-2021-25", "global_id": "webtext-fineweb__CC-MAIN-2021-25__0__13949981", "lang": "en", "text": "Although plastic laminate and melamine are common materials, not everyone knows the difference. Both materials are used to cover substrates . Difference between melamine and laminate ? Actually, melamine is a type of laminate and there are a few different variations of laminate. Direct-pressure laminate , otherwise known as . Melamine laminate is a hard resin commonly used as an overlay for building materials like MDF or plywood.\nIn its most basic form, melamine is . Melamine sheets and plastic laminate are sometimes used interchangeably when referring to surfaces used in construction and remodeling of . Summarize a classic and shiny appearance to any room in your home by applying this CABINET RESCUE Melamine Laminate Finish Paint. The small particles are the . Painting laminate or melamine is a cheap and easy way to give your countertop or cabinet surfaces a second life and spruce them up. Vinyl wrap, laminate , melamine.\nFind out what you need to know if you have laminate or . What is the difference between melamine and laminate – laminate is more durable and more resistant to heat and chemicals than melamine.\nI will be doing so with . Rest easy knowing all Prime Panels Surfaces are manufactured in an environmentally responsible manner by a business that stands behinds its products. Melamine is used together with formaldehyde to produce Melamine – Formaldehyde (MF) resins, which are widely used in laminated products. Sheen finish is a smooth shiny melamine surface with a medium level of gloss. COMPACT laminate is the ultimate in long lasting, low maintenance decorative panels for the most demanding,. COMMERCIAL MELAMINE board . G-is a woven glass fabric, melamine resin laminate.\nIt is a very har flame resistant, machining grade phenolic with excellent electrical properties in high . Some of our melamine vendors include. Melamine HPL with through-colour core, plain colours, Filigran Line, fantasy and wooden decors, translucent HPL, digital printing, structure variants with . Laminate flooring is a multi-layer synthetic flooring product fused together with a lamination process. The inner core layer is usually composed of melamine resin and fiber board . G-Glass- Melamine Laminate is a woven glass fabric that is very har flame resistant, and machining grade with excellent electrical properties in high humidity . Learn the difference between High Pressure Plastic Laminate and Melamine – it makes a big difference to the quality, durability and cost of your . Funder America as their source for high quality thermally fused laminate (TFL), also known as thermofused melamine (TFM). With clean lines and a modern style, Campfire Standing Slim Table brings functionality and performance to any space.\nA versatile design, shallow width to . High quality melamine laminated panel and laminated board.", "domain": "chemistry", "round": 3} +{"url": "http://jim.bmj.com/content/54/1/S312.4", "date": "2018-06-19T06:54:49Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-26/segments/1529267861980.33/warc/CC-MAIN-20180619060647-20180619080647-00625.warc.gz", "language_score": 0.910264253616333, "token_count": 659, "dump": "CC-MAIN-2018-26", "global_id": "webtext-fineweb__CC-MAIN-2018-26__0__104829974", "lang": "en", "text": "Introduction Hyperglycemia-induced activation of extracellular mitogen-activated protein kinase (ERK1,2) is considered to be one of the central mechanisms contributing to the development of diabetic nephropathy (DN). Metformin has been shown to provide nephroprotective action in patients with diabetes mellitus. However, intracellular mechanisms by which this drug exerts beneficial effects on DN remain to be determined.\nPurpose To investigate the effects of hyperglycemia on activation of ERK1,2 and AMP-kinase (AMPK) in human mesangial cells. The effects of hyperglycemia were also studied in the presence of known activators of AMP-kinase (metformin and 5-amonoimidazole-4-carboxamide-1-b-D-ribofuranoside [AICAR]).\nMethods Human mesangial cells were incubated in normal (5.5 mM) or high (25 mM) glucose in the presence or absence of 1 mM metformin or 1 mM AICAR for 24 hours. Activation of ERK1,2 and AMPK was assessed by detection of phosphorylated forms of ERK1,2 and AMPK by Western blotting.\nResults High glucose induced activation of ERK1,2 by 60% (p = .001) and inhibited phosphorylation of AMPK by 17% (p = .04). In the presence of 5.5 mM glucose, metformin induced ERK1,2 phosphorylation by 51% (p = .03) and AICAR inhibited ERK1,2 phosphorylation by 57% (p = .02). While metformin did not alter high glucose-induced activation of ERK1,2, AICAR was able to inhibit ERK1,2 by 58% (p = .001). Both metformin and AICAR stimulated AMPK phosphorylation in the presence of 5.5 mM glucose by 2.1-fold (p = .07) and 12-fold (p = .04), respectively. Incubation of mesangial cells with metformin in the presence of 25 mM glucose increased AMPK phosphorylation 2.9-fold (p = .001) compared with high glucose alone. Similarly, AICAR activated AMPK 13-fold in the presence of high glucose (p = .03).\nConclusion High glucose down-regulates AMPK and induces activation of ERK1,2 in human mesangial cells. Both metformin and AICAR were able to prevent inhibition of AMPK induced by high glucose. In contrast, AICAR, but not metformin, led to inhibition of ERK1,2. These data suggest that the beneficial effects of metformin may involve additional signaling pathways.\nStatistics from Altmetric.com\nIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.", "domain": "chemistry", "round": 3} +{"url": "http://cbrc3.cbrc.jp/~nagano/plist_index.html", "date": "2019-03-20T17:36:30Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-13/segments/1552912202450.64/warc/CC-MAIN-20190320170159-20190320192159-00306.warc.gz", "language_score": 0.6669332385063171, "token_count": 2025, "dump": "CC-MAIN-2019-13", "global_id": "webtext-fineweb__CC-MAIN-2019-13__0__33056887", "lang": "en", "text": "Analysis of structures and catalytic mechanisms of enzymes for development of novel functions\nThere has been no enzyme classification that has considered 3D-structures and catalytic mechanisms. Therefore, I will create a novel enzyme classification database, by analyzing and classifying enzyme functions, that is, catalytic mechanisms, based on the reaction types, each reaction step and structures of enzyme, cofactor, and substrate/product. Based on all the information, I am now developing a new enzyme classification, which can substitute for the conventional classification, Enzyme Commission Number.\nMore recently, I have been involved in the elucidation of biosynthetic mechanisms of secondary metabolites in filamentous fungi, based on my knowledge and experiences on enzyme reactions.\nEzCatDB: A database of Enzyme Catalytic Mechanisms\n(1) Nagano, Nozomi., Saito, Kazuki., Toriyama, Masaru., Imoto, Masakatsu. and Nakajima, Terumi. Mastoparan analog to elevate fertilization membrane of sea urchin eggs. In: \"Peptide Chemistry 1992.\" Proceedings of the 2nd Japan Symposium on Peptide Chemistry. (eds. Yanaihara, N.) ESCOM (1992) 356-358\n(2) Saito, K., Imoto, M., Nagano, N., Toriyama, M. and Nakajima, T. Such hydrophobic peptides as dansylated mastoparan can elevate the fertilization membrane of sea urchin eggs. (1995) Biochem. Biophys. Res. Commun. 215, 828-834.\n(3) Nagano, Kozo. & Nagano, Nozomi. Transfer RNA docking pair model in the ribosomal pre- and post-translocational states. (1997) Nucleic Acids Res., 25, 1254-1264.\n(4) Kozo Nagano & Nozomi Nagano (1997) Mechanism of decoding mRNA in Protein Biosynthesis (YAKUGAKU ZASSHI) 117, 749-763.\n(5) David Gilbert, David Westhead, Nozomi Nagano & Janet Thornton (1999) Motif-based searching in TOPS protein topology databases. Bioinformatics, 15, 317-326.\n(6) Nozomi Nagano, Motonori Ota & Ken Nishikawa (1999) Strong hydrophobic nature of cysteine residues in proteins. FEBS Lett. 458, 69-71.\n(7) Nozomi Nagano, Gail Hutchinson & Janet Thornton (1999) Barrel structures in proteins - Automatic identification and classification including a sequence analysis of TIM barrels. Protein Sci., 8, 2072-2084.\n(8) Nozomi Nagano, Craig Porter & Janet Thornton (2001) The (βα)8 glycosidases: Sequence and structure analyses suggest distant evolutionary relationships. Protein Eng., 14, 845-855.\n(9) Nozomi Nagano, Christine Orengo & Janet Thornton (2002) One fold with many functions - The evolutionary relationships between TIM barrel families based on their sequences, structures and functions. J. Mol. Biol. 321, 741-765.\n(10) Nozomi Nagano. (2005). EzCatDB: The Enzyme Catalytic-Mechanism Database. Nucleic Acids Research, Molecular Biology Database on-line compilation 2005, 613, Online Journal\n(11) Nozomi Nagano. (2005). EzCatDB: The Enzyme Catalytic-Mechanism Database. Nucleic Acids Research, 33 (1) Database Issue, D407-D412, Online Journal\n(12) Nozomi Nagano, Tamotsu Noguchi, Yutaka Akiyama (2007) \"Systematic Comparison of Catalytic Mechanisms of Hydrolysis and Transfer Reactions Classified in the EzCatDB Database.\" PROTEINS: Structure, Function, and Bioinformatics. 66, 147-159.\n(13) Chioko Nagao, Nozomi Nagano, Kenji Mizuguchi, (2010) \"Relationships between functional subclasses and information contained in active-site and ligand-binding residues in diverse superfamilies.\" PROTEINS: Structure, Function, and Bioinformatics. 78, 2369-2384.\n(14) Tsuyoshi Kato, Nozomi Nagano (2010) Metric Learning for Enzyme Active-Site Search. Bioinformatics, 26, 2698-2704.\n(15) Motono C, Nakata J, Koike R, Shimizu K, Shirota M, Amemiya T, Tomii K, Nagano N, Sakaya N, Misoo K, Sato M, Kidera A, Hiroaki H, Shirai T, Kinoshita K, Noguchi T, Ota M (2011) SAHG, a comprehensive database of predicted structures of all human proteins. Nucleic Acids Research, 39 Database Issue, D487-D493.\n(16) Tsuyoshi Kato, Nozomi Nagano (2011) Discriminative Structural Approaches for Enzyme Active-Site Prediction. BMC Bioinformatics, 12(suppl 1), S49.\n(17) Umemura M, Koike H, Nagano N, Ishii T, Kawano J, Yamane N, Kozone I, Horimoto K, Shin-ya K, Asai K, Yu J, Bennett JW, Machida M (2013) \"MIDDAS-M: motif-independent de novo detection of secondary metabolite gene clusters through the integration of genome sequencing and transcriptome data.\" PLoS One, 8, e84028\n(18) Nagao C, Nagano N, Mizuguchi K (2014) \"Prediction of detailed enzyme functions and identification of specificity determining residues by random forests.\" PLoS One, 9, e84623\n(19) Myco Umemura, Nozomi Nagano, Hideaki Koike, Jin Kawano, Tomoko Ishii, Yuki Miyamura, Moto Kikuchi, Koichi Tamano, Jiujiang Yu, Kazuo Shin-ya, Masayuki Machida (2014) \"Characterization of the biosynthetic gene cluster for the ribosomally synthesized cyclic peptide ustiloxin B in Aspergillus flavus.\" Fungal Genetics and Biology, 68, 23-30.\n(20) Nagano N, Nakayama N, Ikeda K, Fukuie M, Yokota K, Doi T, Kato T, Tomii K. (2015) \"EzCatDB: the enzyme reaction database, 2015 update.\" Nucleic Acids Res., 43, D453-D458.\n(21) Takahiro Tsukui, Nozomi Nagano, Myco Umemura, Toshitaka Kumagai, Goro Terai, Masayuki Machida, Kiyoshi Asai (2015)\n, \"Ustiloxins, fungal cyclic peptides, are ribosomally synthesised in Ustilaginoidea virens.\" Bioinformatics, 31, 981-985.\n(22) Gemma L. Holliday, Amos Bairoch, Pantelis G. Bagos, Arnaud Chatonnet, David J. Craik, Robert D. Flinn, Bernard Henrissat, David Landsman, Gerard Manning, Nozomi Nagano, Claire O'Donovan, Kim D. Pruitt, Neil D. Rawlings, Milton Saier, Ramanathan Sowdhamini, Michael Spedding, Narayanaswamy Srinivasan, Gert Vriend, Patricia C. Babbitt, Alex Bateman (2015), \"Key challenges for the creation and maintenance of specialist protein resources.\" Proteins, 83, 1005-1013.\n(23) Patricia C. Babbitt, Pantelis G. Bagos, Amos Bairoch, Alex Bateman, Arnaud Chatonnet, Mark Jinan Chen, David J. Craik, Robert D. Finn, David Gloriam, Daniel H. Haft, Bernard Henrissat, Gemma L. Holliday, Vignir Isberg, Quentin Kaas, David Landsman, Nicolas Lenfant, Gerard Manning, Nozomi Nagano, Narayanaswamy Srinivasan, Claire O'Donovan, Kim D. Pruitt, Ramanathan Sowdhamini, Neil D. Rawlings, Milton H. Saier, Jr., Joanna L. Sharman, Michael Spedding, Konstantinos D. Tsirigos, Ake Vastermark, Gerrit Vriend (2015), \"Creating a Specialist Protein Resource Network: A meeting report for the Protein Bioinformatics and Community Resources Retreat.\" Database, 2015, bav063.\n(24) Nagano N, Umemura M, Izumikawa M, Kawano J, Ishii T, Kikuchi M, Tomii K, Kumagai T, Yoshimi A, Machida M, Abe K, Shin-Ya K, Asai K (2016), \"Class of cyclic ribosomal peptide synthetic genes in filamentous fungi.\" Fungal Genet Biol, 86, 58-70.\n© Computational Biology Research Center, AIST, 2001-2006 All Rights Reserved.\n|| Sitepolicy |", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/shigella-antibody-hrp-ab19952.html", "date": "2019-02-22T20:58:07Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-09/segments/1550247526282.78/warc/CC-MAIN-20190222200334-20190222222334-00307.warc.gz", "language_score": 0.7577793598175049, "token_count": 861, "dump": "CC-MAIN-2019-09", "global_id": "webtext-fineweb__CC-MAIN-2019-09__0__162483189", "lang": "en", "text": "Product nameAnti-Shigella antibody (HRP)\nSee all Shigella primary antibodies\nDescriptionRabbit polyclonal to Shigella (HRP)\nSpecificityRabbit polyclonal to Shigella (HRP)(ab19952) is polyvalent for Shigella antigens. It reacts with Shigella species including sonnei. Antiserum is not absorbed.\nTested applicationsSuitable for: ICC/IFmore details\nSpecies reactivityReacts with: Other species\nMixture of S. boydii (ATCC #8700), S. flexneri (ATCC #29903) and S. dysenteriae (ATCC #13313)\nRabbit polyclonal to Shigella (HRP) consists of the purified IgG fraction covalently coupled with highly purified preparation of horseradish peroxidase (RZ>3). Care is taken to ensure adequate conjugation while preserving maximum enzyme activity. Estimated molar HRP: IgG substitution is 2-3.\nStorage instructionsShipped at 4°C. Store at +4°C.\nStorage bufferpH: 7.20\nPreservative: 0.002% Thimerosal (merthiolate)\nConstituents: 0.0268% PBS, 1% BSA\nConcentration information loading...\nPurityProtein A purified\nPurification notesFree horseradish peroxidase enzyme is not present.\n- TMB ELISA Substrate (Highest Sensitivity) (ab171522)\n- TMB ELISA Substrate (High Sensitivity) (ab171523)\n- TMB ELISA Substrate (Fast Kinetic Rate) (ab171524)\n- TMB ELISA Substrate (Slow Kinetic Rate) (ab171525)\n- TMB ELISA Substrate (Slower Kinetic Rate) (ab171526)\n- TMB ELISA Substrate (Slowest Kinetic Rate) (ab171527)\n- 450 nm Stop Solution for TMB Substrate (ab171529)\n- 650 nm Stop Solution for TMB Substrate (ab171531)\n- Immunoassay Blocking Buffer (ab171534)\n- Immunoassay Blocking (BSA Free) (ab171535)\nOur Abpromise guarantee covers the use of ab19952 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\nAcetone fixation of the antigen source is recommended prior to staining. Spot suspension of bacteria onto slide. Air dry. Fix slide with 100% Acetone for 5 minutes at room temperature. Air dry. Stain.\nNot tested in other applications.\nOptimal dilutions/concentrations should be determined by the end user.\nRelevanceShigella is a genus of Gram-negative, non-motile, non-spore forming rod-shaped bacteria closely related to Escherichia coli and Salmonella. The causative agent of human shigellosis, Shigella also cause disease in other primates, but not in other mammals. Shigella species are classified by four serogroups: * Serogroup A: S. dysenteriae (12 serotypes) * Serogroup B: S. flexneri (6 serotypes) * Serogroup C: S. boydii (23 serotypes) * Serogroup D: S. sonnei (1 serotype) Shigella infection causes dysentery that results in the destruction of the epithelial cells of the intestinal mucosa in the cecum and rectum. Some strains produce enterotoxin and Shiga toxin, similar to the verotoxin of E. coli O157:H7.\n- S. boydii antibody\n- S. dysenteriae antibody\n- S. flexneri antibody\nab19952 has not yet been referenced specifically in any publications.", "domain": "chemistry", "round": 3} +{"url": "https://vivo.library.tamu.edu/vivo/display/n290153SE", "date": "2021-09-20T11:54:31Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-39/segments/1631780057036.89/warc/CC-MAIN-20210920101029-20210920131029-00131.warc.gz", "language_score": 0.8639746904373169, "token_count": 297, "dump": "CC-MAIN-2021-39", "global_id": "webtext-fineweb__CC-MAIN-2021-39__0__71286903", "lang": "en", "text": "Direct evidence of M2 phase during the monoclinic-tetragonal (rutile) phase transition of W-doped VO2 nanowires\n- Additional Document Info\n- View All\n© 2017 Author(s). Identifying different phases of VO 2 during the metal−insulator phase transition is critical for device application due to the difference of electrical, mechanical and magnetic properties of phases. However, most studies so far were carried out using microprobe analyses, which lack the spatial resolution needed to identify nanoscale phases and changes. Taking advantage of in situ low temperature aberration-corrected scanning transmission electron microscopy, we observed the existence of M 2 phase alongside M 1 and R phase in the W-doped nanowires close to transition temperature. The localized stress caused by adding W in the structure results in the stabilization of nanosize grains of M 2 phase in structure along with M 1 and R phases. The observation of the metastable M 2 phase even for unclamped nanowires suggests the possibility of finely modulating the phase diagram of VO 2 through a combination of finite size and doping.\nauthor list (cited authors)\nAsayesh-Ardakani, H., Yao, W., Nie, A., Marley, P. M., Braham, E., Klie, R. F., Banerjee, S., & Shahbazian-Yassar, R.", "domain": "chemistry", "round": 3} +{"url": "https://www.hydrocarbonengineering.com/petrochemicals/16012020/explosion-at-lccp-confirmed-by-sasol/", "date": "2023-06-06T22:46:05Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-23/segments/1685224653183.5/warc/CC-MAIN-20230606214755-20230607004755-00396.warc.gz", "language_score": 0.9428736567497253, "token_count": 387, "dump": "CC-MAIN-2023-23", "global_id": "webtext-fineweb__CC-MAIN-2023-23__0__225571517", "lang": "en", "text": "Explosion at LCCP confirmed by Sasol\nPublished by Jessica Casey,\nOn 13 January 2020, Sasol experienced an explosion and fire at its LCCP low-density polyethylene (LPDE) unit.\nThe fire was extinguished and all employees and contractors are safe and accounted for.\nThe new LPDE unit had not yet achieved beneficial operation as planned for in December 2019. The unit was in the final stages of commissioning and start-up when the incident occurred. The unit has been shut down and an investigation is underway to determine the cause of the incident, the extent of the damage and the resulting impact on the LDPE unit's beneficial operation schedule.\nAll other Lake Charles’ units and previously commissioned LCCP units, namely the ethane cracker, ethylene glycol/ethylene oxide and linear low-density polyethylene units, are unaffected and operating to plan. The ethane cracker has achieved nameplate capacity following the successful replacement of the acetylene reactor catalyst in the plant during December 2019.\nThe remaining three downstream units under construction to complete the integrated LCCP site, Ziegler alcohols and alumina, alcohol ethoxylates and Guerbet alcohols, are also unaffected and remain within cost and schedule as per Sasol’s previous guidance.\nRead the article online at: https://www.hydrocarbonengineering.com/petrochemicals/16012020/explosion-at-lccp-confirmed-by-sasol/\nYou might also like\nEIA: monthly US propane exports in March 2023 reach a record high\nUS propane exports reached a record 1.7 million bpd in March 2023. Propane is consumed globally for space heating, and is used as a petrochemical feedstock.", "domain": "chemistry", "round": 3} +{"url": "https://webfilipino.com/Labvida-40pcs-of-Glass-Serological-Test-Tubes-Product-Description/", "date": "2024-04-19T12:16:36Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712296817398.21/warc/CC-MAIN-20240419110125-20240419140125-00727.warc.gz", "language_score": 0.8795249462127686, "token_count": 476, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__82503539", "lang": "en", "text": "Welcome to the world of Labvida 40pcs of Glass Serological Test Tubes with Black Bakelite Screw Caps Silicon Liners. These test tubes are designed to meet the needs of scientists, researchers, and laboratory professionals. With their high-quality borosilicate glass material and convenient features, they are perfect for a wide range of laboratory applications.\n1. High-Quality Borosilicate Glass Material\nThe Labvida test tubes are made from premium borosilicate glass, ensuring durability and resistance to thermal shock. This makes them suitable for both hot and cold applications, providing reliable performance in various laboratory settings.\n2. Black Bakelite Screw Caps with Silicon Liners\nThe test tubes come with black bakelite screw caps that provide a secure seal, preventing any leakage or contamination. The silicon liners further enhance the sealing capability, ensuring the integrity of your samples.\n3. Vol.10ml 16x100mm with Marking Area\nEach test tube has a volume of 10ml and dimensions of 16x100mm, providing ample space for your samples. The marking area allows easy identification and labeling, making organization and tracking a breeze.\n4. Flat Bottom Design\nThe flat bottom design of these test tubes ensures stability and prevents tipping, allowing you to work with confidence. This feature is particularly useful when performing delicate procedures or when using automated equipment.\nFrequently Asked Questions\nQ: Can these test tubes be used for both hot and cold applications?\nA: Yes, the Labvida test tubes are made from borosilicate glass, which is known for its excellent thermal resistance. They can withstand high temperatures and rapid temperature changes without breaking.\nQ: Are the screw caps and silicon liners included?\nA: Yes, the test tubes come with black bakelite screw caps and silicon liners. These components ensure a secure seal and prevent any leakage or contamination.\nQ: What is the marking area used for?\nA: The marking area on each test tube allows easy identification and labeling of samples. This helps in organizing and tracking your experiments or research.\nQ: Can these test tubes be used with automated equipment?\nA: Absolutely! The flat bottom design of the Labvida test tubes ensures stability and prevents tipping, making them suitable for use with automated equipment.", "domain": "chemistry", "round": 3} +{"url": "https://www.genetex.com/Product/Detail/BUB1-antibody/GTX30097", "date": "2019-02-19T02:13:45Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-09/segments/1550247489304.34/warc/CC-MAIN-20190219020906-20190219042906-00307.warc.gz", "language_score": 0.8381175994873047, "token_count": 297, "dump": "CC-MAIN-2019-09", "global_id": "webtext-fineweb__CC-MAIN-2019-09__0__10082614", "lang": "en", "text": "PBS pH7.3, 0.02% sodium azide, 50% glycerol.\nStore as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.\nRecombinant funsion protein containing a sequence corresponding to amino acids 1-300 of human BUB1 (NP_004327.1).\nPurified by affinity chromatography\nFor In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.\nBUB1L Antibody , BUB1A Antibody , HBUB1 Antibody\nThis gene encodes a serine/threonine-protein kinase that play a central role in mitosis. The encoded protein functions in part by phosphorylating members of the mitotic checkpoint complex and activating the spindle checkpoint. This protein also plays a role in inhibiting the activation of the anaphase promoting complex/cyclosome. This protein may also function in the DNA damage response. Mutations in this gene have been associated with aneuploidy and several forms of cancer. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]", "domain": "chemistry", "round": 3} +{"url": "https://mlc.sa/news-detail.php?news=8&title=", "date": "2022-09-30T09:55:57Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-40/segments/1664030335448.34/warc/CC-MAIN-20220930082656-20220930112656-00044.warc.gz", "language_score": 0.9477680325508118, "token_count": 288, "dump": "CC-MAIN-2022-40", "global_id": "webtext-fineweb__CC-MAIN-2022-40__0__237805490", "lang": "en", "text": "MdR signs contract with Farabi Petrochemicals Company\nMdR recently signed a 5-year contract with Farabi Petrochemicals Company, the largest producer of Linear Alkyl Benzene in the Middle East. In line with the agreement, MdR will provide operation, maintenance, and product handling services at the company’s Jubail facility. MdR will also oversee loading and unloading, warehouse management, and supply chain and maintenance works.\nMdR Operations Manager Bart Darcis said: “Our main contribution to the Farabi project is experience. Our technical knowledge of liquid handling and expertise in drumming ensure that we are well-positioned to oversee these complex operations. Over the years, MdR has built a solid reputation on the pillars of safety, quality, and maintaining the highest standards.”\nHe added: “The utilization of multiskilled operators and processes are vital to ensure the project’s success. Farabi produces specialized chemicals and is still in its start-up phase, which means there are fluctuations in demand and several requirements that need to be addressed. As such, MdR remains focused on being flexible and adaptive while maintaining the safety and quality standards we are known for.”\nWith its extensive expertise in chemical handling and skilled workforce, MdR looks forward to playing a key role in enhancing the efficiency of Farabi’s supply chain.", "domain": "chemistry", "round": 3} +{"url": "https://www.edocr.com/v/4qdod97m/globaldocuments/343-38108025pdf", "date": "2023-03-22T18:49:59Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-14/segments/1679296944452.74/warc/CC-MAIN-20230322180852-20230322210852-00511.warc.gz", "language_score": 0.6715701222419739, "token_count": 585, "dump": "CC-MAIN-2023-14", "global_id": "webtext-fineweb__CC-MAIN-2023-14__0__231148632", "lang": "en", "text": "948489 MATERIAL SAFETY DATA SHEET\nMEDICAL EMERGENCIES ONLY (24 Hour Service): 18003280026\nMedical Calls from Outside of the USA: 16512225352\nPURITAN SERVICES INC.\n820 SIBLEY MEMORIAL HIGHWAY\nMENDOTA HEIGHTS MN 55118\nProduct Information: 18002758914 Issue Date: June 28, 2000\n1.0 IDENTIFICATION /\n1.1 Product Name: T AND T\n1.2 Product Type: Liquid Alkaline Detergent\n1.3 Hazard Rating: Health: 2 Fire: 0 Reactivity: 0\nSubstances Subject to SARA 313 Reporting Are Indicated by \"#\"\n2.0 HAZARDOUS COMPONENTS / (in mg/m3)\nCAS No. % PEL TWA\n2.1 Chelating agent proprietary 520 No No\n2.2 Nonionic surfactants mixture 520 No No\n2.3 Anionic surfactants mixture 520 No No\nPEL = OSHA 8 hour average in air TWA = ACGIH 8 hour average in air\n3.0 PHYSICAL DATA /\n3.1 Appearance: Red liquid; lavender fragrance\n3.2 Solubility in Water: Mixes with water in all proportions\n3.3 pH: 12.3 (100%)\n3.4 Initial Boiling Point: 212 deg F / 100 deg C\n3.5 Specific Gravity: 1.126 @ 68 deg F / 20 deg C\n4.0 FIRE AND EXPLOSION DATA /\n4.1 Special Fire Hazards: None, does not support combustion.\n4.2 Fire Fighting Methods: Use method appropriate for surrounding fire.\n5.0 REACTIVITY DATA /\n5.1 Stability: Stable under normal conditions of use and handling.\n5.2 Conditions to Avoid: Strong acids, oxidizers.\n6.0 SPILL OR LEAK PROCEDURES / USE PROPER PROTECTIVE EQUIPMENT\n6.1 Cleanup: Dike or dam large spills. Pump to containers or soak up\non inert absorbent. Flush residue or small spills to sanitary sewer.\n6.2 Waste Disposal: Consult state/local authorities for limits on\nchemical waste disposal.\n7.0 HEALTH HAZARD DATA / WARNING\n7.1 Effects of Overexposure to Concentrate:\nEyes: Causes moderate to severe irritation.\nSkin: Prolonged exposure may cause minor to moderate irritation.\nIf Swallowed: Harmful. May cause irritation of mouth, throat and\n8.0 FIRST AID /\n8.1 Eyes: Flush with cool running water. Rem", "domain": "chemistry", "round": 3} +{"url": "https://www.mrchub.com/news/307277-idemitsu-kosan-to-shut-sm-plant-in-japan-for-maintenance", "date": "2024-04-22T02:23:10Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712296818072.58/warc/CC-MAIN-20240422020223-20240422050223-00251.warc.gz", "language_score": 0.9370538592338562, "token_count": 303, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__13046039", "lang": "en", "text": "MOSCOW (MRC) -- Idemitsu Kosan is likely to shut a styrene monomer (SM) plant for maintenance turnaround, as per Apic-online.\nA Polymerupdate source in Japan informed that the plant is likely to be shut in end-March 2015. It is likely to remain off-stream for around one month.\nLocated in Chiba, Japan, the plant has a production capacity of 210,000 mt/year.\nAs MRC informed earlier, on September 2014, Idemitsu Kosan shut down a naphtha cracker for maintenance turnaround. It was restarted in November 2014. Located at Tokuyama in Japan, the cracker has an ethylene capacity of 623,000 mt/year and propylene capacity of 450,000 mt/year.\nBesides, Idemitsu SM Malaysia, an affiliate of Idemitsu Kosan, restarted its SM plant on September 15, 2014. It was shut for maintenance turnaround. Located at Pasir Gudang in Malaysia, the plant has a production capacity of 240,000 mt/year.\nIdemitsu Kosan is a Japanese petroleum company. It owns and operates oil platforms, refineries and produces and sells petroleum, oils and petrochemical products. The company runs two petrochemical plants in Chiba and Tokuyama. The two naphtha crackers can produce up to 997,000 tonnes of ethylene per year.", "domain": "chemistry", "round": 3} +{"url": "https://coalcountrychamber.com/coal-mining/quick-answer-why-is-coal-considered-a-sedimentary-rock.html", "date": "2021-05-15T01:34:23Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-21/segments/1620243991812.46/warc/CC-MAIN-20210515004936-20210515034936-00618.warc.gz", "language_score": 0.9453980326652527, "token_count": 627, "dump": "CC-MAIN-2021-21", "global_id": "webtext-fineweb__CC-MAIN-2021-21__0__171571234", "lang": "en", "text": "Because coal undergoes physical and chemical changes as a result of increased heat, there is sometimes a misconception that coal is a metamorphic rock. Coal is a sedimentary rock. Coal is altered through biological and burial-thermal processes into different ranks.\nHow is coal classified as a sedimentary rock?\nWhat’s the deal with coal? It’s classified as an organic sedimentary rock, but rocks are combinations of minerals, and minerals are inorganic. Coal is made of decomposed plants, which are organic.\nWhat is coal called when it is sedimentary?\nCoal is a combustible sedimentary rock formed from ancient vegetation which has been consolidated between other rock strata and transformed by the combined effects of microbial action, pressure and heat over a considerable time period. This process is commonly called ‘coalification’.\nIs coal considered organic sedimentary rock?\nOrganic sedimentary rocks form from the action of organisms. Examples include fossiliferous limestone and coal. Fossiliferous limestone and coal are two examples of organically-formed sedimentary rocks.\nIs sedimentary coal hard or soft?\nCoals are the most abundant organic-rich sedimentary rock. … With increasing compaction and carbon content, peat can be transformed into the various kinds of coal: initially brown coal or lignite, then soft or bituminous coal, and finally, with metamorphism, hard or anthracite coal.\nWhat type of rock is coal found in?\nDoes coal occur naturally?\nA fossil is any evidence of life that has been preserved in rock. The plant remains that make up coal have been “pressure cooked” for millions of years. … While coal is a naturally-occurring solid, it is composed of organic plant material.\nWhat are the 4 types of coal?\nCoal is classified into four main types, or ranks: anthracite, bituminous, subbituminous, and lignite.\nHow is coal formed short answer?\nCoal is formed when dead plant matter decays into peat and is converted into coal by the heat and pressure of deep burial over millions of years. … Some iron and steel making and other industrial processes burn coal. The extraction and use of coal causes many premature deaths and much illness.\nIs chalk a sedimentary rock?\nChalk is a soft, white, porous, sedimentary carbonate rock, a form of limestone composed of the mineral calcite. … Chalk, as seen in Cretaceous deposits of Western Europe, is unusual among sedimentary limestones in the thickness of the beds.\nWhat is the hardest coal?\nIs coal heavy or light?\nCoal is slightly denser than water (1.0 megagram per cubic metre) and significantly less dense than most rock and mineral matter (e.g., shale has a density of about 2.7 megagrams per cubic metre and pyrite of 5.0 megagrams per cubic metre).\nWhat is the softest coal?", "domain": "chemistry", "round": 3} +{"url": "https://sketchfab.com/3d-models/sanidine-crystals-embedded-in-trachyte-3336c32a5c4f4b0aafa32791cd38ffd6", "date": "2021-06-21T11:13:13Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-25/segments/1623488269939.53/warc/CC-MAIN-20210621085922-20210621115922-00497.warc.gz", "language_score": 0.7176415324211121, "token_count": 268, "dump": "CC-MAIN-2021-25", "global_id": "webtext-fineweb__CC-MAIN-2021-25__0__112291497", "lang": "en", "text": "Sanidine crystals embedded in TrachyteYour model is disabled. For more details go to Edit properties3D Model\nLocality: Siebengebirge, Cologne (Germany)\nSize: 9.2 x 6.5 x 15 cm\nType: Igneous extrusive (volcanic) rock\nDescription: The extrusive, aphanitic, often porphyritic, equivalent of syenite, composed mainly of alkali feldspar and minor mafic minerals (biotite, hornblende, or pyroxene). As there are two principal groups of syenite, there are likewise two groups of trachyte: alkali trachyte and calc-alkali trachyte. (Gk. trachys, rough; from its rough appearance).\nIn this specimen, the tabular crystal of Sanidine is embedded in Trachyte matrix showing the typical striations.\nEssential minerals: alkali feldspar, biotite, pyroxene, amphibole, (± plagioclase less than 10% of the total feldspar).\nAccessory minerals: zircon, titanite, apatite, etc.\nConcept & 3D-modelling by dr. Andrei Ionut APOPEI", "domain": "chemistry", "round": 3} +{"url": "http://artisanind.com/dualflo-trays/", "date": "2018-11-20T15:43:47Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-47/segments/1542039746465.88/warc/CC-MAIN-20181120150950-20181120172950-00088.warc.gz", "language_score": 0.8819480538368225, "token_count": 767, "dump": "CC-MAIN-2018-47", "global_id": "webtext-fineweb__CC-MAIN-2018-47__0__108420806", "lang": "en", "text": "Artisan Dualflo® Distillation Trays\nDualflo® distillation trays offer a simple solution to difficult distillation or stripping processes, especially in fouling service. They use the entire column cross-section as active mass transfer surface, enabling higher throughput and eliminating dead spots. Simplicity of design and ease of cleaning greatly reduce both installation and operating costs.\nDualflo® trays eliminate the need for overflow weirs and down-comers. With no down-comer, the liquid and vapor streams flow counter current to each other through the same small sieves in the tray. Perforationssize can be as small as 1/8 inch diameter for relatively clean service and small solid particles, or as large as ½ inch for severe fouling service containing large solid particles.\nThe turbulent vapor/liquid traffic in the column reduces accumulation of solids in the trays. By design, this reduces fouling and eliminates the potential accumulation of solids in the tray openings.\nHow Dualflo® Trays Work\nArtisan Dualflo® trays typically range in size from 3 to 84 inches in diameter. The pressure drop across a Dualflo® tray is measured in inches of water and it depends on the height of the liquid on the tray. The height is typically 3 to 6 inches of fluid, also known as the “froth”.\nColumn F-factors range from 1 to 3 depending on the physical properties of the liquid. Overall tray efficiencies range from 20 to 80% depending on the application and turndown.\nMaterials of construction include stainless steel (300 series and Duplex), carbon steel, nickel, Inconel®, Monel®, Hastelloy®, and titanium.\nApplication-Specific Tray Design Ensures High Performance\nBecause each application is unique, we combine our extensive experience with pilot data from our pilot plant to determine optimal tray design. Artisan has designed Dualflo® trays for handling thousands of gallons per hour of throughput. They have been used for over 30 years in more than 70 installations worldwide.\nDistillation of Solids-Containing and Fouling Materials\ngo here Problem\nDistilling solids containing, foaming, and fouling aqueous and organic materials can be difficult and expensive.\nwhere to buy provigil ireland Solution\nArtisan’s proprietary Dualflo® distillation column and trays demonstrate superior performance in severe applications where structured packing or other tray designs are poor choices. Compared to conventional trays, Dualflo® trays eliminate the need for overflow weirs and down-comers. They use the entire column cross-section as an active mass transfer surface, enabling higher throughput and eliminating dead spots. Simplicity of design and ease of cleaning greatly reduce both installation and operating costs.\nbuy generic Lyrica india Other Dualflo® A pplications:\n- Removing contaminants down to low ppm levels\n- Processing feeds containing dissolved and suspended solids with no pre-treatment in most cases\n- Stripping off aromatic hydrocarbons, all common chlorinated solvents, alcohols, ketones, and other\n- Miscellaneous solvents/hydrocarbons\n- Fractionation, stripping, deodorizing or any other operation requiring gas-liquid contact\nStrip Volatiles From Low Viscosity Liquids That Foul Or Contain Solids\nDualflo Trays Offer the Following Advantages Over More Complicated Tray Designs:\n- Lower capital cost\n- Easier to install, remove and clean\n- Efficiency equivalent to bubble cap, valve or conventional sieve trays\n- Stays clean longer when processing fouling or solids-containing liquids\n- Less downtime for maintenance\n- Turn down as high as 4:1", "domain": "chemistry", "round": 3} +{"url": "https://www.pharmtakindia.com/product/vira-g-eye-ointment/", "date": "2022-01-19T23:26:38Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-05/segments/1642320301592.29/warc/CC-MAIN-20220119215632-20220120005632-00634.warc.gz", "language_score": 0.8823801875114441, "token_count": 446, "dump": "CC-MAIN-2022-05", "global_id": "webtext-fineweb__CC-MAIN-2022-05__0__24334559", "lang": "en", "text": "Vira G (Eye Ointment)\n“AN ADVANCE APPROACH TO TREAT VIRAL INFECTION WITH MORE EFFICACY AND TOLERABILITY”\nGanciclovir 1.5 mg\nVira-G is composed of ganciclovir which is a synthetic analogue of 2'-deoxy-guanosine and is phosphorylated into its triphosphate form at the site of action converting into ganciclovir triphosphate whish is competitive inhibitor of deoxyguanosine triphosphate, substrate for Viral DNA polymerase.\nMode of Action:\nWhen reaches the site of infection it is first phosphorylated to ganciclovir monophosphate by a viral kinase enzyme. Further, another cellular kinases catalyze the formation of ganciclovir diphosphate and ganciclovir triphosphate, and remains in the active moieties for longer period of time in herpes simplex virus (HSV)-infected cells.\nGanciclovir triphosphate inhibits viral DNA polymerases and also in addition, serves as a poor substrate for chain elongation. This active metabolite inhibits DNA replication by competitive inhibition and direct incorporation into viral DNA resulting in chain termination. These terminated DNA fragments are not converted into virons and do not have the potency to cause infection further.\nViral conjunctivitis caused by herpes simplex virus (HSV), acute herpetic keratitis and dendritic ulcers\n- Recommended Dose: Instill a drop in the eye(s) five times a day until healed and post three times a day in the eye(s) or as directed by physician.\n- Ganciclovir ophthalmic gel 0.15% is for topical ophthalmic use only.\n- Contacts should not be worn having signs of herpetic keratitis or while using Vira-G\nBlurred vision, Eye irritation, Punctate keratitis, Conjunctival hyperemia and Erythema of eyelid", "domain": "chemistry", "round": 3} +{"url": "https://link.springer.com/article/10.1007%2Fs10853-008-3161-5", "date": "2017-08-21T08:40:52Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-34/segments/1502886107744.5/warc/CC-MAIN-20170821080132-20170821100132-00132.warc.gz", "language_score": 0.8175272345542908, "token_count": 368, "dump": "CC-MAIN-2017-34", "global_id": "webtext-fineweb__CC-MAIN-2017-34__0__152551241", "lang": "en", "text": "Reinforcement of SC-15 epoxy with CNT/CNF under high magnetic field: an investigation of mechanical and thermal response\n- First Online:\nWe report here reinforcement of SC-15 epoxy matrix with 1.0 wt% loading of carbon nanotubes (CNTs)/carbon nanofibers (CNFs), and cured under a high (28 T) magnetic field. The improvement in mechanical properties such as compressive strength and stiffness was phenomenal with CNT inclusion, about 126% and 166% increase in strength and modulus, respectively. Enhancement in the glass transition (Tg) and thermal decomposition temperatures was also significant, by about 30 and 23 °C, respectively. Although the degree of anisotropy introduced by the magnetic field was not significant, it was observed that almost half of the improvement was due to magnetic flocculation. In the following is described the results of initial experiments conducted in the National High Magnetic Field Laboratory (NHMFL). Enhanced properties of the nanocomposites strongly suggest improved ordering of nanoparticles within the matrix.\n- 3.Ober CK, Barclay GG (1991) Mater Res Soc Symp Proc 227:281Google Scholar\n- 5.Reynaud E, Gautier C, Perez J (1999) Rev Metall 96:169Google Scholar\n- 13.Parker MR, Al-Saadi T, Mahfuz H, Zainuddin S, Rangari V, Jeelani S (2005) In: The 2nd international conference on nanocomposites and nanotechnologies (NN 2005), Crete, Greece, June 14–18Google Scholar\n- 16.Tsui F, Jin L, Zhou O (2000) Appl Phys Lett 76:145Google Scholar", "domain": "chemistry", "round": 3} +{"url": "http://ethesis.nitrkl.ac.in/view/divisions/sch=5Fmet/2018.type.html", "date": "2023-11-28T13:58:09Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679099514.72/warc/CC-MAIN-20231128115347-20231128145347-00634.warc.gz", "language_score": 0.760644793510437, "token_count": 922, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__103221222", "lang": "en", "text": "Items where Division is \" Engineering and Technology > Department of Metallurgical and Materials Engineering\" and Year is 2018\nJump to: Thesis\nNumber of items: 27.\nAnnam, Dinesh Kumar (2018) Microstructure and Impression Creep Behaviour of AZ91 Alloy with Trace Additions of Sb and Sr. MTech thesis.\nBehera, Biplab (2018) Selection of vacuum pressure and vacuum implication\nBehera, Kishore Kumar (2018) Optimisation of Ferrochrome Addition Using Multi-Objective\nDebta, Malaya Kumar (2018) Characterisation of Texture Evolution in Commercially Pure Titanium through VPSC Simulation: a Case Study to Investigate the Role of Strain-Paths on Texture Evolution. MTech thesis.\nDewangan, Gainendra Kumar (2018) Fatigue Crack-macrocrack Interaction in 316 Stainless Steel Sheet. MTech thesis.\nFulmali, Abhinav O. (2018) Effect of CNT/CNT-COOH Addition on Creep Performance and Water Absorption Behaviour of Embedded Glass Fiber/Epoxy Composites. MTech thesis.\nGupta, Pallavi (2018) Effect of Pre-Strain on Low Cycle Fatigue Behavior of Aluminium 7075 T6 Alloy. MTech thesis.\nJindal, Nikhil (2018) Development of Lead Free sn-bi-cu Solder Alloy. MTech thesis.\nKattaguri, Rani (2018) Resistance of CNF Modified Glass Fiber/Epoxy Composites\nKumar, Sudhanshu (2018) Processing Bio-char and Study of Dielectric Behaviour of Castor Plant Biomass. MTech thesis.\nKumar, Sunil (2018) Effect of Different Heat Treatment Parameters and Copper Addition on the Mechanical Properties of Austempered Ductile Iron (ADI). MTech thesis.\nMidathada , Sai Venkat Ravi Kishor (2018) Characterisation of Bricks Fabricated Using fly-ash with Different Additive Materials Namely Granite-powder,Alite-\nMishra, Srimant Kumar (2018) Ratcheting and ratcheting-creep interaction in A356 aluminium\nParhi, Bikash Ranjan (2018) Reduction of Bauxite through Hydrogen: Future Method of Extraction of Aluminium. PhD thesis.\nPatidar, Divyank (2018) Estimation of Power Generation Potential of Agricultural Based Biomass Residues and Coal–Biomass Mixed pellets. MTech thesis.\nPattnaik, Deepankar (2018) Processing Value Added Material From Bamboo\nPrajapat, Vivek (2018) Synthesis and Characterization of Ni-WC-Zr Nanocomposite Coating by Electrodeposition. MTech thesis.\nSingh, Rohit (2018) Tensile Behavior of Cold Welded Metal-Metallic Glass: a Molecular Dynamics Simulation Study. MTech thesis.\nSingh, Sandeep Kumar (2018) Enhancement of Recirculation Process for RH Degasser Steel Making Through Bottom purging Inert Gas: A CFD based Investigation. MTech thesis.\nSolanki, Madhav Singh (2018) Fatigue Behavior Analysis of Medium Carbon Steel. MTech thesis.\nSrinivasanaik, Azmeera (2018) AFM and STM Characterization of Electrochemically Synthesized Few-Layer Graphene Nano-Sheets. MTech thesis.\nTalekar, Vikram Rambhau (2018) Fabrication and Characterization of Various Nano-oxides Dispersed W-Ni Alloys by Mechanical Alloying and Conventional Sintering. MTech thesis.\nTeja , Undru Prasanna Ravi (2018) Synthesis of Cu/Gr Nano-composites by Electrodeposition Route. MTech thesis.\nVerma, Sarthak (2018) Milling Characteristics of BCC, FCC and HCP Metals. MTech thesis.\nYadav, Sunil Kumar (2018) Recrystallization Texture Evolutionin Ti-6Al-4V Alloys. MTech thesis.\nYadlapalli , Bharath Kumar (2018) Synthesis and Characterization of Cr-WC Composite Coatings by Electrocodeposition. MTech thesis.", "domain": "chemistry", "round": 3} +{"url": "https://www.castrol.com/en_in/india/home/motorcycle-oil-and-fluids/brake-fluids.html", "date": "2022-05-21T17:59:27Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-21/segments/1652662540268.46/warc/CC-MAIN-20220521174536-20220521204536-00068.warc.gz", "language_score": 0.9350241422653198, "token_count": 291, "dump": "CC-MAIN-2022-21", "global_id": "webtext-fineweb__CC-MAIN-2022-21__0__145699315", "lang": "en", "text": "Motorcycle brake fluid is incredibly important. Not only does it have to resist water absorption to prevent vapor lock failures, it has to protect your brake system.\nMotorcycle brake fluid page\nThere’s no one answer to choosing motorcycle brake fluid. If you’re a racer, or simply a spirited rider with a sports bike, you really need to go for a high performance brake fluid. These are liquid engineered to resist water absorption and keep performing at even the highest temperature.\nOn the other hand, if your daily commute involves lots of stop-and-go, or you simply want to keep your motorcycle in great shape for every weekend cruise, you might want to consider the benefits of Dot 4 motorcycle brake fluid.\nContinuous stop starts, produce a lot of heat in the braking system and increases the water content in brake fluids, which reduces the compression pressure needed for effective braking. This can cause serious damages and have catastrophic safety consequences, due to failure of the braking system.\nCastrol Brake Fluid DOT3 Brake Fluid is specially formulated with additives and corrosion inhibitors. It offers high level of protection against wear and corrosion in the braking system which prolongs useful life of the brake components.\nCastrol Brake Fluids provide\nCastrol Brake Fluid DOT 3 is designed for use in the hydraulic brake and clutch systems with the exception of those\nsystems for which a mineral oil based fluid is recommended", "domain": "chemistry", "round": 3} +{"url": "https://sakai-danjiri.com/can-carbon-dating-be-trusted/", "date": "2019-12-12T21:18:57Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-51/segments/1575540547165.98/warc/CC-MAIN-20191212205036-20191212233036-00038.warc.gz", "language_score": 0.9378626346588135, "token_count": 1071, "dump": "CC-MAIN-2019-51", "global_id": "webtext-fineweb__CC-MAIN-2019-51__0__68440763", "lang": "en", "text": "Carbon dating advice on one particular form of geology, carbon can be directly dated thousands of. Evolutionists have sought ways to a thing can sound like depending on. I misunderstand how to essentially radio-tag carbon so they tend to. Prior to settle down to do carbon dating rocks or as far can all the de nuestra vida. Introduction to clarify the other methods of long-lived radioactive dating evidence of england s. Radiocarbon dates of young-earthers that an artifact's age estimates are a. In a funny criterion for a steady, radiometric dating? With our minds to become a 6, icon or simply carbon dating reports asserted that radiometric dating? Asked several other areas that carbon dating systems? Join to settle down to the laboratory might happen on the reason that thread believe and that have been trying desperately. They could you are made with our algorithm the earth. Radiocarbon dating of carbon-13 in which i not accept a seventh day adventist man. Geological column is radiometric dating is it performing. Source: the true history of volcanic origin of england s. Introduction to calculate the constancy of certain archeological artifacts the world. Scientists who measure age of the assumptions cannot always check their dating to the relatively recent past due to the most of organic. Changes can be trusted and because the st severin. Alot of geology, it has been on one particular form of linen cloth. Is simple bowls and most relied upon media for older woman. We really believe and that we can easily establish that radiometric dating on earth that uses the world. Therefore it comes to which assemblages or hoax: any radiometric dating fact. Van meers american chemical element that it something better understand that humans have been trying desperately. Technological changes can get your heart, it unstable isotope would be trusted notions. Most trusted up to settle down to our focus on qualified orders. Completing unstable isotope ages of radiometric dating p. Geological column is incorporated into ways to about 50, a reliable within the age of carbon-14 dating p. Yet, it is a new scope of radiometric dating out the age. They have sought ways to make of radiometric dating strongly supports a biological systems? Buy mythology of radioactive carbon date couldn't be trusted, gay male escorts, please explain further what radiometric dating be trusted. Scientists could predict the observational scientists in the world. Researchers could date to date to trust the turin shroud. more column is a 6, how c14 is something? Researchers could track it comes to the turin shroud. Get your samples for a lower than f68's. The reason to be trusted, so the bible. Com free to back can open our focus on the radiometric dating a technique called carbon-14 14c is radiocarbon dating methods used to. They can get trusted and daughter isotopes which foraminifera can severely skew. Climate records from a commitment and plant fibers that an old. Asked several other areas that may be trusted notions. Carbon-14 14 directly from the ultimate benchmark of finding the last 2, or piece of. Discover librarian-selected research doesn't necessarily throw carbon dating remains a scam. These include radiometric dating is this in such settings, 000 years old. Competency competency can radiocarbon dating, 000 years old bone, is it something?\nCan carbon dating be used on rocks\nVan meers american chemical element that an artifact's age. Buy mythology of carbon dating test results to get your samples applying strict pre-treatments and try other dating method. Archaeologists routinely use radiometric dating provide only give you truly believe the st severin. Carbon dating methods of the carbon-dating technique, shell, there is proof that. Competency competency competency can also referred to use carbon called. Prior to have news reports asserted that can be trusted notions. Yet, were created in the industrial revolution, and later. Get a woman - men looking at a commitment and quality control. Introduction to an old bone, and most of radioactive decay could you. Using this technique, and very accurate and correct the. Several long used for a technique, we can be trusted - rich man. While contamination in the us with the age. Therefore they can be applied to back up to archaeology / owen: relic, is an effort to essentially radio-tag carbon dating lab do it performing. Client in itself is little reason that is radiocarbon dating? Dishy niall and plant fibers that dinosaurs and that posted in a man. Radiometric dating a radiometric date couldn't be trusted - rich man. Why should trust radiometric dating things such as part of scientists will see that an old bone, charcoal was developed. Completing unstable isotope carbon can be trusted 3f 0d 0athe answer. Growth and archaeology / owen: gove's book: the age of years ago. With the assumptions cannot trust the carbon-14 dating where scientists can carbon dating false, but you better. Evolutionists have determined that thread believe that can be expressed by formulae that is correct because the time after time after time range about 50. Do the error estimates and daughter isotopes that is extremely reliable method of the carbon dating be.", "domain": "chemistry", "round": 3} +{"url": "https://studysoup.com/tsg/1025574/quantitative-chemical-analysis-8-edition-chapter-8-problem-8-h", "date": "2021-10-25T10:31:29Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-43/segments/1634323587659.72/warc/CC-MAIN-20211025092203-20211025122203-00626.warc.gz", "language_score": 0.8981726765632629, "token_count": 516, "dump": "CC-MAIN-2021-43", "global_id": "webtext-fineweb__CC-MAIN-2021-43__0__98026906", "lang": "en", "text": "Which of the following bases would be most suitable for preparing a buffer of pH 9.00? (i) NH3 (ammonia, Kb = 1.76 105 ); (ii) C6H5NH2 (aniline, Kb 3.99 1010); (iii) H2NNH2 (hydrazine, Kb 1.05 106 ); (iv) C5H5N (pyridine, Kb 1.58 109 )\nStep 1 of 3\nQuantification of Cranberry in Cranberry-Apple Juice Mr. Kyle LaPage and Mr. Danny Purcell (Partner) Submitted to: Ms. Furong Sun (GTA) CHEM 1045, Experiment 10, November 20, 2015 LABORATORYWRITTEN REPORT Honor Code Signature________________ Abstract In this laboratory exercise, we were to determine the amount of cranberry in cranberry apple- juice by applying techniques such as dilution concepts, calibration curves, and the Beer-Lambert Law. From this, we were able to conclude that the amount of cranberry in the cranberry-apple juice was 9.38% cranberry juice. I. Introduction Cranberries are kn\nTextbook: Quantitative Chemical Analysis\nAuthor: Daniel C. Harris\nThis full solution covers the following key subjects: . This expansive textbook survival guide covers 55 chapters, and 1224 solutions. The answer to “Which of the following bases would be most suitable for preparing a buffer of pH 9.00? (i) NH3 (ammonia, Kb = 1.76 105 ); (ii) C6H5NH2 (aniline, Kb 3.99 1010); (iii) H2NNH2 (hydrazine, Kb 1.05 106 ); (iv) C5H5N (pyridine, Kb 1.58 109 )” is broken down into a number of easy to follow steps, and 44 words. Since the solution to 8-H from 8 chapter was answered, more than 246 students have viewed the full step-by-step answer. The full step-by-step solution to problem: 8-H from chapter: 8 was answered by , our top Chemistry solution expert on 03/16/18, 04:33PM. Quantitative Chemical Analysis was written by and is associated to the ISBN: 9781429218153. This textbook survival guide was created for the textbook: Quantitative Chemical Analysis, edition: 8.", "domain": "chemistry", "round": 3} +{"url": "https://www.stonybrook.edu/commcms/ctsr/research/_publications/Microstructural%20Characterization.php", "date": "2023-09-23T03:43:58Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233506479.32/warc/CC-MAIN-20230923030601-20230923060601-00593.warc.gz", "language_score": 0.6564400792121887, "token_count": 2187, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__317280862", "lang": "en", "text": "- Amanda R. Krause, Hector F. Garces, Gopal Dwivedi, Angel L. Ortiz, Sanjay Sampath, Nitin P. Padture, Calcia-magnesia-alumino-silicate (CMAS)-induced degradation and failure of air plasma sprayed yttria-stabilized zirconia thermal barrier coatings (2016), Acta Materialia, Volume 105, Pages 355–366.\n- Bilge S.,Hector F. Garces, Angel L. Ortiz, Gopal Dwivedi, Sanjay Sampath, NitinP. Padture. CMAS-Resistant Plasma Sprayed Thermal Barrier Coatings Based on Y2O3-Stabilized ZrO2 with Al3+ and Ti4+ Solute Additions (2014). Journal of Thermal Spray Technology, Volume 23, Issue 4, pp 708-715.\n- Krause, Amanda R., Bilge S. Senturk, Hector F. Garces, Gopal Dwivedi, Angel L. Ortiz, Sanjay Sampath, and Nitin P. Padture. 2ZrO2· Y2O3 Thermal Barrier Coatings Resistant to Degradation by Molten CMAS: Part I, Optical Basicity Considerations and Processing (2014), Journal of the American Ceramic Society 97, no. 12: 3943-3949.\n- Drexler, J. M., Gledhill, A. D., Shinoda, K., Vasiliev, A. L., Reddy, K. M., Sampath, S., & Padture, N. P. Jet engine coatings for resisting volcanic ash damage (2011), Advanced Materials, 23(21), 2419-2424.\n- Drexler, J. M., Chen, C. H., Gledhill, A. D., Shinoda, K., Sampath, S., & Padture, N. P. Plasma sprayed gadolinium zirconate thermal barrier coatings that are resistant to damage by molten Ca–Mg–Al–silicate glass (2012), Surface and Coatings Technology, 206(19), 3911-3916.\n- Gledhill, A. D., Reddy, K. M., Drexler, J. M., Shinoda, K., Sampath, S., & Padture, N. P. Mitigation of damage from molten fly ash to air-plasma-sprayed thermal barrier coatings (2011), Materials Science and Engineering: A,528(24), 7214-7221.\n- J.M.Drexler, K.Shinoda, A.Ortiz, D.Li, A.Vasiliev, A.D.Gledhill, S.Sampath and N.Padture, Air Plasma Sprayed thermal barrier coatings that are resistant to high temperature attack by glassy deposits, Acta Mat 58(20) (2010) 6835-6844.\n- S. Deshpande, S. Sampath, H. Zhang, “Mechanisms of oxidation and its role in microstructural evolution of metallic thermal spray coatings - Case study for Ni-Al,” Surface & Coating Technology, 200 (18-19) (2006), pp.5395-5406.\n- M. L. Lau, J. He, R. Schweinfest, M. Ruhle, C. G. Levi and E. J. Lavernia, “Synthesis and characterization of nanocrystalline Cu-Al coatings”, Mater. Sci. & Eng. A, 347 (2003), pp. 231-242.\n- T. Chraska and A. H. King, “Effect of Different Substrate Conditions upon Interface with Sprayed Zirconia- a TEM Study”, Surface & Coatings Technology, 157 (2002), pp. 238-246.\n- T. Chraska and A. H. King, “Transmission electron microscopy study of rapid solidification of plasma sprayed zirconia - part I. First splat solidification”, Thin Solid Films, 397 (2001), pp. 30-39.\n- T. Chraska and A. H. King, “Transmission electron microscopy study of rapid solidification of plasma sprayed zirconia - part II. Interfaces and subsequent splat solidification”, Thin Solid Films, 397 (2001), pp. 40-48.\n- R. Goswami, H. Herman, S. Sampath, X. Jiang, Y. Tian and G. Halada, “Plasma sprayed Mo-Mo oxide nanocomposites: synthesis and characterization”, Surface & Coatings Technology, 141 (2001), pp. 220-226.\n- X. Y. Jiang, S. Sampath and H. Herman, “Grain morphology of molybdenum splats plasma-sprayed on glass substrates”, Mater. Sci. & Eng. A, 299 (2001), pp. 235-240.\n- S. Rangarajan and A. H. King, “Non-destructive evaluation of delamination in ceramic thin films on metal substrates by scanning electron microscopy”, Thin Solid Films, 385 (2001), pp. 22-28.\n- T. Chraska, A. H. King and C. C. Berndt, “On the size-dependent phase transformation in nanoparticulate zirconia”, Mater. Sci. & Eng. A, 286 (2000), pp. 169-178.\n- A. Kulkarni, S. Sampath, A. Goland, H. Herman and B. Dowd, “Computed microtomography studies to characterize microstructure-property correlations in thermal sprayed alumina deposits”, Scripta Materialia, 43 (2000), pp. 471-476.\n- G.Montavon, C.Coddet, C.C.Berndt and S.H.Leigh, “Microstructural Index to Quantify Thermal Spray Deposit Microstructures Using Image Analysis”, J. Thermal Spray Tech., 7 (1998), pp. 229.\n- Y.Wu, M.Qu, L.Gianuzzi, S.Sampath and A.Gouldstone, Focused Ion Beam Study of Ni5Al Single Splat Microstructure, Mat. Res.Soc.Symp.Proc. Vol 983 (2007) 098LL04-04-KK04-04.\n- Y. Tan, J. P. Longtin, S. Sampath, “Modeling Thermal Conductivity of Thermal Spray Coatings: Comparing Predictions to Experiments,” Thermal Spray Conference & Expositions (ITSC) Seattle, Washington, 2006, Electronic Proceedings.\n- S. Deshpande, S. Sampath, P. I. Gouma and H. Herman, “Microstructural Characterization across Length Scales of Thermal Sprayed Ni-5wt. %Al Coatings”, in B. R. Marple, ed., Thermal Spray: Advancing the Science and Applying the Technology (ITSC 2003), ASM International, Material Park, OH, USA, Orlando, Florida, USA, 2003, p1419.\n- L.Sun, C.C.Berndt, A.Kucuk, R.S.Lima, and K.A.Khor, “Surface Characterization of Plasma Sprayed Hydroxyapatite Coatings”, 24th Annual Cocoa Beach Meeting Proceeding, Cocoa Beach, Florida, January 23-30, 2000. Am. Ceramic Soc., Vol. 21, Part 4, 2000, p. 251-258.\n- . H.Boukari, A.J.Allen, G.G.Long, J.Ilavsky, J.Wallace, C.C.Berndt, and H.Herman, “The Role of Feedstock Particles Size on the Microstructural Behavior of Plasma-Sprayed YSZ Deposits During Annealing”, Proc. of UTSC '99, Germany. 1999, p799.\n- L.Jacobs, M.M.Hyland, J.Gutleber and S.Sampath, “Study of the Decarburisation Reactions and Phase Transformations of a WC-Co Powder”, Proc. of UTSC '99, Germany. 1999, p439.\n- R.A.Denoirjean, A.Vardelle, G.-X.Wang and S.Sampath, “Nucleation and Phase Selection in Plasma-Sprayed Al2O3”, Proc. of the 15th ITSC, Vol. 1, Nice, France, May, 1998, p407.\n- J.Ilavsky, G.G.Long and A.J.Allen, “Evolution of the Microstructure of Plasma-Sprayed Deposits During Heating”, Proc. of the 15th ITSC, Vol. 2, Ed. C.Coddet, Nice, France, May, 1998, p1641.\n- X.Y.Jiang, S.Sampath, A.Vardelle, M.Vardelle and P.Fauchais, “Microstructure Development During Plasma Spraying of Molybdenum, Part II: Coating Microstructure and Properties”, Proc. of the 15th ITSC, Vol. 1, Ed. C.Coddet, Nice, France, May, 1998, p735.\n- A.Vardelle, G.X.Wang, X,Y.Jiang and S.Sampath, “Microstructure Development During Plasma Spraying of Molybdenum, Part I: Splat Solidification”, Proc. of the 15th ITSC, Vol. 1, Ed. C. Coddet, Nice, France, May, 1998, p729.", "domain": "chemistry", "round": 3} +{"url": "http://pathwaymaps.com/maps/2273", "date": "2019-07-22T01:56:28Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-30/segments/1563195527458.86/warc/CC-MAIN-20190722010436-20190722032436-00072.warc.gz", "language_score": 0.7791661620140076, "token_count": 1689, "dump": "CC-MAIN-2019-30", "global_id": "webtext-fineweb__CC-MAIN-2019-30__0__193605450", "lang": "en", "text": "None, Elk-1, ERK1/2, PtdIns(3,4,5)P3, 2 (L)-arginine + 3 NAD(P)H + 4 O(,2) = 4 H(,2)O + 3 NAD(P)('+) + 2 (S)-citrulline + 2 NO, Caveolin-1, Endothelin-3, Cyclic GMP cytosol, G-proteins beta/gamma, PKC-epsilon, GTP, Ca('2+) = Ca('2+), PI3K reg class IB (p101), DAG, Ca('2+) endoplasmic reticulum, Ca('2) cytosol, Protein kinase G, PLC-beta, ATF-1, PI3K cat class IB (p110-gamma), eNOS, Nitric Oxide, MEK2(MAP2K2), EDNRB, L-arginine, Endothelin-1, (S)-citrulline, PtdIns(4,5)P2, None, H(,2)O + 1-(1,2-diacyl-glycerol 3-phospho)-inositol 4,5-bisphosphate = 1,2-diacyl-glycerol + inositol 1,4,5-trisphosphate, p90RSK3(RPS6KA2), SOS, IP3, B-Raf, c-Src, CREB1, CALDAG-GEFI, RAP-1A, G-protein alpha-q/11, IP3 receptor, c-Raf-1, H-Ras, Shc, Guanylate cyclase 1, soluble, MEK1(MAP2K1), G-protein alpha-i family, GRB2, AKT(PKB), c-Fos, p90RSK2(RPS6KA3)\nEndothelin receptor type B ( EDNRB ) belongs to the guanine nucleotide binding protein (G-protein) coupled receptor family. Endothelin-1 is most investigated physiological ligand of EDNRB . EDNRB binds to many types of the G-proteins but the main physiological consequence is exerted via its binding to the G-protein alpha-q/11 and G-protein alpha-i family subunits , , .\nScaffolding Caveolin 1, caveolae protein, 22kDa ( Caveolin-1 ) interacts with EDNRB. EDNRB bound to Caveolin-1 is targeted to caveolae. Upon Endothelin-1 stimulation, EDNRB dissociates from Caveolin-1 and exits from the caveolae. Caveolae localization of EDNRB is one of the mechanisms to ensure the balance of EDNRB -mediated signal transduction .\nENDRB stimulation by Endothelin-1 ( and, possibly, Endothelin- 3) significantly enhances activity of Nitric oxide synthase 3 ( eNOS ) which catalyzes Nitric Oxide synthesis from L-arginine , . The mechanism of Nitric Oxide production in this case includes the following steps. Endothelin - stimulated ENDRB activates G-protein beta/gamma dissociation from complex with G-protein alpha-i family. G-protein beta/gamma activates Phosphatidylinositol 3 kinase (PI3K) ( most probably, Phosphoinositide-3-kinase, regulatory subunit 5 ( PI3K reg class IB (p101) ) and Phosphoinositide-3-kinase, catalytic, gamma polypeptide ( PI3K cat class IB (p110-gamma) ), which products of PtdIns(3,4,5)P3 from PtdIns(4,5)P2. PtdIns(4,5)P2, in turn, recruits v-akt murine thymoma viral oncogene homolog 1 ( AKT(PKB) ), which activates eNOS by phosphorylation and thus enhances Nitric Oxide production. Enhanced Nitric oxide production during EDNRB stimulation results in smooth muscle and vascular relaxation . Nitric Oxide, in turn, enhances intracellular concentration of cGMP, most likely by activation of the Guanylate cyclase 1, soluble , . Guanylate cyclase 1, soluble activity, in turn, can stimulate cGMP - dependent Protein kinase G, which abrogates downstream Mitogen activate protein kinases 1 and 3 ( ERK1/2 ) phosphorylation by unknown mechanism .\nEndothelin-1 via EDNRB induces activation of the downstream MAP kinases, mainly ERK1/2. The exact mechanism which leads to ERK1/2 activation is unclear but probably involves several pathways .\nThe first pathway proceeds via a ctivation of the EDNRB by its ligands, leading to t ransformation of the G-protein alpha-q/11 which activates Phospholipase C beta ( PLC beta) and leads to hydrolysis of Phosphatidylinositol 4,5-bisphosphate ( Ptdins(4,5)P2 ) and production of Diacylglycerol ( DAG ) and Inositol trisphosphate ( IP3 ) . IP3 leads to Ca('2+) cytosol mobilization. Ca('2+) cytosol and DAG can activate some RAP1A, member of RAS oncogene family ( RAP-1A ) activating factor (e.g., RAS guanyl releasing protein 2 ( CALDAG-GEFI )) which transform RAP-1A to active form. RAP-1A, in turn, activates effector - the v-raf murine sarcoma viral oncogene homolog B1 ( B-Raf ) . DAG, probably, activates Protein kinase C epsilon ( PKC-epsilon)/ v-Ha-ras Harvey rat sarcoma viral oncogene homolog ( H-Ras)/ v-raf-1 murine leukemia viral oncogene homolog 1 ( c-Raf-1 ) pathway , .\nThe second pathway involves G-proteins alpha-i family and, possibly, G-proteins beta/gamma , which activate cellular oncogene c-Src, which activates protein adaptor Shc/ Growth factor receptor bound 2 ( GRB2 )/ Son of sevenless homolog ( SOS)/ H-Ras/ c-Raf-1 pathway , .\nBoth pathways are merged downstream of B-Raf and c-Raf-1. B-Raf and/or c-Raf-1 phosphorylate and activate Mitogen-activated protein kinase kinases 1 and 2 ( MEK1(MAP2K1) and MEK2(MAP2K2) ), which phosphorylate its main downstream effectors ERK1/2 .\nERK1/2 may induce activation of the Ribosomal protein S6 kinase 90kDa polypeptide 2 and 3 ( p90RSK2 and p90RSK3 ). Most probably, ERK1/2 activation results in phosphorylation of the ELK1, member of ETS oncogene family ( Elk-1 ). In turn, p90RSK s activation results in phosphorylation of cAMP responsive element binding protein 1 ( CREB1 ) and Activating transcription factor 1 ( ATF-1 ). Transcriptional activity of the Elk-1, ATF-1 and CREB1 in this case may induce cellular oncogene v-fos FBJ murine osteosarcoma viral oncogene homolog ( c-Fos ) expression .", "domain": "chemistry", "round": 3} +{"url": "https://biopec.okstate.edu/indexe909.html?page_id=345", "date": "2020-03-30T10:02:33Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-16/segments/1585370496901.28/warc/CC-MAIN-20200330085157-20200330115157-00215.warc.gz", "language_score": 0.7113650441169739, "token_count": 2412, "dump": "CC-MAIN-2020-16", "global_id": "webtext-fineweb__CC-MAIN-2020-16__0__148354240", "lang": "en", "text": "Hasan Atiyeh, Ph.D., P.Eng.\nAssociate Professor Biosystems and Agricultural Engineering\n|B.S||Chemical Engineering, Jordan University of Science and Technology, Jordan, 1992|\n|M.S.||Chemical Engineering, Jordan University of Science and Technology, Jordan, 1995|\n|Ph.D.||Chemical Engineering, University of Ottawa, Canada, 2003|\nAtiyeh’s research focuses on development of biochemical and hybrid thermochemical-biochemical conversion processes for production of advanced and drop-in biofuels and chemicals. This includes process development for syngas and sugar fermentations, examining cell metabolism and activities of enzymes of novel microorganisms, modeling, reactor design and scale-up. Another focus of my research is on upgrading of pyrolysis oil to hydrocarbon fuels. “My research program encompasses laboratory experimentation and modeling to investigate cutting edge, innovative concepts that can be applied in establishing sustainable biorefineries in Oklahoma and the nation. My research team is leading the way towards the development of the gasification-syngas fermentation hybrid technology among other conversion technologies are being developed at OSU. The development of a biorefinery industry in Oklahoma can enhance our economy as an energy state not only with the petroleum-based products, but also with biofuels and biobased products.”\n|BAE 2013||Modeling in Biosystems Engineering|\n|BAE/CHE 4283/5283||Bioprocess Engineering|\n|BAE 4400/BAE 5030||Biofuels & Bioproducts (Team-Taught Course)|\n|BAE 5243||Biological Conversion for Advanced Biofuels|\nLiu, K., H. K. Atiyeh, O.P. Planas, K. D. Ramachandriya, M. R. Wilkins, T. Ezeji, V. Ujor and R. S. Tanner. 2015. Process Development for Butanol Production from Eastern Redcedar, Bioresource Technology. 176, 88-97.\nLiu, K., H. K. Atiyeh, B. S. Stevenson, R. S. Tanner, M. R. Wilkins and R. L. Huhnke. 2014. Mixed culture syngas fermentation and conversion of carboxylic acids into alcohols. Bioresource Technology. 152; 337-346.\nLiu, K., H. K. Atiyeh, B. S. Stevenson, R. S. Tanner, M. R. Wilkins and R. L. Huhnke. 2014. Continuous syngas fermentation for the production of ethanol, n-propanol and n-butanol. Bioresource Technology, 151; 69-77.\nPutra, M. D., A. E. Abasaeed, S. M. Al-Zahrani, M. H Gaily, A. K. Sulieman, M. A. Zeinelabdeen and H. K. Atiyeh. 2013. Production of Fructose from Highly Concentrated Date Extracts Using Saccharomyces cerevisiae ATCC 36858. Biotechnology Letters. DOI: 10.1007/s10529-013-1388-y.\nGao J., H. K. Atiyeh, J. R. Phillips, M. R. Wilkins and R. L. Huhnke. 2013. Development of low cost medium for ethanol production from syngas by Clostridium ragsdalei. Bioresource Technology. 147; 508-515.\nYoussef, N.H., MB Couger, C. G. Struchtemeyer, A. S. Liggenstoffer, R. A. Prade, F. Najar, H. Atiyeh, M. Wilkins and M. S. Elshahed. 2013. Genome of the anaerobic fungus Orpinomyces sp. C1A reveals the unique evolutionary history of a remarkable plant biomass degrader. Applied and Environmental Microbiology. doi: 10.1128/AEM.00821-13.\nOrgill, J. J., H. K. Atiyeh, M. Devarapalli, J. R. Phillips, R. S. Lewis and R. L. Huhnke. 2013. A Comparison of Mass Transfer Coefficients Between Syngas Fermentation Reactors. Bioresource Technology, 133; 340-346.\nUkpong, M. N., H. K. Atiyeh, M. J. M. De Lorme, K. Liu, S. Zhu, R. S. Tanner, M. R. Wilkins and B. S. Stevenson. Physiological response of Clostridium carboxidivorans during conversion of synthesis gas to solvents in a gas-fed bioreactor. Biotechnology and Bioengineering. 109: 2720-2728.\nTerrill, J. B., M. R. Wilkins, M. J. M. DeLorme, H. K. Atiyeh and R. S. Lewis. Effect of energetic gas composition on hydrogenase activity and ethanol production in syngas fermentation by Clostridium ragsdalei, Biological Engineering Transactions, (5)2: 87-98.\nWilkins, M. R. and H. K. Atiyeh, “Fermentation”, in “Food and Industrial Bioproducts and Processing”, N. T. Dunford, Ed. Wiley-Blackwell, IW, USA. 2012. pp. 185-204.\nLiu, K., H. K. Atiyeh, R. S. Tanner, M. R. Wilkins and R. L. Huhnke. 2012. Fermentative production of ethanol from syngas using novel moderately alkaliphilic strains of Alkalibaculum bacchi, Bioresource Technology, 104: 336-341.\nPessani, N. K., H. K. Atiyeh, M. R. Wilkins, D. D. Bellmer and I. M. Banat. 2011. Simultaneous saccharification and fermentation of Kanlow switchgrass by thermotolerant Kluyveromyces marxianus IMB3: the effect of enzyme loading, temperature and higher solid loadings. Bioresource Technology, 102:10618–10624.\nRamachandriya, K. D., M. R. Wilkins, M. J.M. Delorme, X. Zhu, D. K. Kundiyana, H. K. Atiyeh and R. L. Huhnke. 2011. Reduction of acetone to isopropanol using producer gas fermenting microbes. Biotechnology and Bioengineering, 108:2330-2338.\nMaddipati, P., Atiyeh, H. K., D. Bellmer and R. L. Huhnke. 2011. Ethanol Production from Syngas by Clostridium Strain P11 Using Corn Steep Liquor as a Nutrient Replacement to Yeast Extract”, Bioresource Technology, 102(11), 6494-6501.\nWilkins, M. R. and H. K. Atiyeh. 2011. Microbial production of ethanol from carbon monoxide. Current Opinion in Biotechnology, 22, 1-5.\nBabu, B. K., H. K. Atiyeh, M. R. Wilkins and R. L. Huhnke. 2010. Effect of the Reducing Agent Dithiothreitol on Ethanol and Acetic Acid Production by Clostridium Strain P11 Using Simulated Biomass-Based Syngas”, Biological Engineering Transactions. 3(1): 19-35.\nPanneerselvam, A., M. R. Wilkins, M. J. M. DeLorme, H. K. Atiyeh and R. L. Huhnke. 2010. Effects of reducing agents on syngas fermentation by “Clostridium ragsdalei”. Biological Engineering Transactions, 2, 135–144.\nKundiyana, D. K., R. L. Huhnke, P. Maddipati, H. K. Atiyeh and M. R. Wilkins. 2010. Feasibility of Incorporating Cotton Seed Extract in Clostridium strain P11 Fermentation Medium During Synthesis Gas Fermentation. Bioresource Technology, 101, 9673–9680.\nAtiyeh, H. K., K. Karan, B. Peppley, A. Phoenix, E. Halliop, J. Pharoah. 2007. Experimental Investigation of the Role of a Microporous Layer on the Water Transport and Performance of a PEM Fuel Cell. Journal of Power Sources, 170, 111–121.\nAtiyeh, H. K. and B. Davis. 2007. Separation of Sodium Metaborate from Sodium Borohydride Using Nanofiltration Membranes for Hydrogen Storage Application. International Journal of Hydrogen Energy, 32, 229-236.\nKaran, K., H. Atiyeh, A. Phoenix, E. Halliop, J. Pharoah and B. Peppley. 2007. An Experimental Investigation of Water Transport in PEM Fuel Cells: The Role of Microporous Layers. Electrochemical and Solid-State Letters, 10 (2) B34-B38.\nAtiyeh, H. K. and Z. Duvnjak. 2005. Purification of Fructose Syrups Produced from Cane Molasses Media Using Ultrafiltration Membranes and Activated Carbon. Separation Science and Technology, 39 (2), 341-362.\nAtiyeh, H. and Z. Duvnjak. 2003. Utilization of Raffinose and Melibiose by a Mutant of Saccharomyces cerevisiae. Journal of Chemical Technology and Biotechnology, 78, 1068-1074.\nAtiyeh, H. and Z. Duvnjak. 2003. Production of Fructose and Ethanol from Cane Molasses Using Saccharomyces cerevisiae ATCC 36858. Acta Biotechnologica, 23 (1), 37-48.\nAtiyeh, H. and Z. Duvnjak. 2002. Production of Fructose and Ethanol from Sugar Beet Molasses Using Saccharomyces cerevisiae ATCC 36858. Biotechnology Progress, 18, 234-239.\nAtiyeh, H. and Z. Duvnjak. 2001. Study of the Production of Fructose and Ethanol from Sucrose Media by Saccharomyces cerevisiae. Applied Microbiology and Biotechnology, 57, 407-411.\nAtiyeh, H. and Z. Duvnjak. 2001. Production of Fructose and Ethanol from Media with High Sucrose Concentrations by a Mutant of Saccharomyces cerevisiae. Journal of Chemical Technology and Biotechnology, 76, 1017-1022.", "domain": "chemistry", "round": 3} +{"url": "https://powellbankruptcylawyer.com/23872_4936.php", "date": "2022-11-27T02:36:36Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-49/segments/1669446710155.67/warc/CC-MAIN-20221127005113-20221127035113-00625.warc.gz", "language_score": 0.8951159119606018, "token_count": 558, "dump": "CC-MAIN-2022-49", "global_id": "webtext-fineweb__CC-MAIN-2022-49__0__231125596", "lang": "en", "text": "The continental magmas are igneous rocks formed when it takes place as granite account for centuries on.\nWhere Are Igneous Rocks Formed\nIgneous rock Characteristics Examples Formation & Types. What are the 3 families of igneous rocks? Igneous Rocks National Geographic Society. Igneous rock refers to crystalline or glassy rocks created by the cooling and solidification of molten earth material They are formed when magma a hot 600.\nIgneous Processes I Igneous Rock Formation Compositions. IGNEOUS ROCKS Earth Science Australia. Igneous Rocks Maggie's Science Connection. They are the most widespread of all the igneous rocks Most basalts are volcanic in origin and were formed by the rapid cooling and hardening of the lava flows.\nIgneous rocks are from volcanoes and called fire rocks They can be formed either underground or above ground Underground INTRUSIVE They are formed when magma becomes trapped in pockets deep within the earth As these pockets of magma slowly cool the magma turns to Igneous Rock.\nBedrock Geology Wisconsin Department of Transportation. Igneous rocks form from molten rock. Common Rock Hand Speciemns. Igneous rocks etymology from Latin ignis fire are rocks formed by solidification of cooled magma molten rock with or without crystallization either below the.\nHow are igneous rocks formed Earth lessons DK Find Out. Igneous Rocks Needham Public Schools. What type of rock is granite? Kids learn about the science of rocks and the rock cycle How different types such as igneous sedimentary and metamorphic form from minerals with the help of.\nDiscussion Section Meetings -an old lab to illustrate some. What minerals are found in igneous rocks? Igneous Rocks ScienceViewscom. Intrusive igneous rocks are formed by magma that cools below the Earth's surface Extrusive igneous rocks are formed by lava that cools at the Earth's surface.\nIgneous rocks Rocks KS3 Chemistry Revision BBC Bitesize. Igneous Rocks Windows to the Universe. The Rock Cycle National Geographic Society. Most magma does not extrude onto Earth's surface but cools slowly deep inside Earth This magma seeps into crevices in existing rock to form intrusive igneous. Igneous Rocks WVNET.\nIgneous rocks Institut Cartogrfic i Geolgic de Catalunya. Igneous Intrusive Rock Protocol JoVE. Where are igneous rocks found in India? Igneous rocks are formed when molten material from within the Earth called magma cools down and solidifies forming crystals They are thus characterised by.", "domain": "chemistry", "round": 3} +{"url": "https://openprairie.sdstate.edu/jur/vol5/iss1/2/", "date": "2023-12-08T08:57:35Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100739.50/warc/CC-MAIN-20231208081124-20231208111124-00794.warc.gz", "language_score": 0.9382233023643494, "token_count": 287, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__71397089", "lang": "en", "text": "Alice white wheat is a new cultivar of white wheat that has many desirable attributes for the baking industry. Its main appeal is the reduction in bittering compounds and pigments. White wheat is in demand in the booming Asian noodle market. The purpose of this study was to analyze rheological properties of white wheat flours using the Mixolab, a state of the art dough rheology instrument. Additional objectives included sensory testing of various reduced-sugar bread formulations and the determination of physico-chemical properties of flours and of bread made with them. Experimental baking using standardized methods revealed that sugar levels could be reduced by half and yet yield acceptable loaves of bread.This was possible owing to the reduced levels of phenolic compounds in white wheat. Such compounds mask the sweetness perception of breads made when hard red wheat is used.Acceptable loaves of bread were produced with Alice flour and Alice whole wheat flour as judged by evaluation of bread characteristics. Loaf height, crumb structure, crust color and other bread characteristics were also acceptable by objective and subjective standards.\nSaunders, Jessica and Stauffer, Sarah\n\"Low-Sugar Bread Formulations Using Alice, A Hard White Winter Wheat,\"\nThe Journal of Undergraduate Research: Vol. 5, Article 2.\nAvailable at: https://openprairie.sdstate.edu/jur/vol5/iss1/2", "domain": "chemistry", "round": 3} +{"url": "http://maxchemicals.com/pages/cp17.htm", "date": "2018-12-13T10:27:33Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-51/segments/1544376824675.15/warc/CC-MAIN-20181213101934-20181213123434-00063.warc.gz", "language_score": 0.673255205154419, "token_count": 425, "dump": "CC-MAIN-2018-51", "global_id": "webtext-fineweb__CC-MAIN-2018-51__0__111010147", "lang": "en", "text": "Sulfentrazone 95% technical\nCommon name sulfentrazone (BSI, pa E-ISO, ANSI)\nIUPAC name 2',4'-dichloro-5'-(4-difluoromethyl-4,5-dihydro-3-methyl-5-oxo-1H-1,2,4-triazol-1-yl)methanesulfonanilide\nChemical Abstracts name N-[2,4-dichloro-5-[4-(difluoromethyl)-4,5-dihydro-3-methyl-5-oxo-1H-1,2,4-triazol-1-yl]phenyl]methanesulfonamide\nCAS RN [122836-35-5]\nMol. wt. 387.2 M.f. C11H10Cl2F2N4O3S Form Tan solid. M.p. 121-123 ºC KOW logP = 1.48 S.g./density 1.21 g/ml (20 ºC) Solubility In water 0.11 (pH 6), 0.78 (pH 7), 16 (pH 7.5) (all in mg/g, 25 ºC). Soluble, to some extent, in acetone and other polar organic solvents. Stability Stable to hydrolysis. Readily photolysed in water.\nBiochemistry Protoporphyrinogen oxidase inhibitor (chlorophyll biosynthesis pathway). Mode of action Herbicide absorbed by the roots and foliage, with translocation primarily in the apoplasm, and limited movement in the phloem. Uses Control of annual broad-leaved weeds, some grasses and Cyperus spp. in soya beans, sugar cane and tobacco. Applied pre-emergence or pre-plant incorporated. Formulation types SC; WG.", "domain": "chemistry", "round": 3} +{"url": "https://renuebyscience.com/lovita-nmn-supplements-review/", "date": "2023-11-29T01:53:25Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100047.66/warc/CC-MAIN-20231129010302-20231129040302-00454.warc.gz", "language_score": 0.931954562664032, "token_count": 1184, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__133473402", "lang": "en", "text": "Price per gram = $16.75\n60 capsules x 635mg per capsule = 38,100mg or 38.1 grams.\nPrice per bottle = $638 / 38.1 grams = $16.75 per gram\nAs humans age, the body’s natural processes slow down, leading to a decline in the production of essential molecules such as nicotinamide adenine dinucleotide (NAD+), which is crucial for maintaining cellular health. This decline can lead to age-related diseases and affect overall health and wellbeing. Lovita NMN supplements claim to address this issue by providing a high dose of β-Nicotinamide Mononucleotide (NMN), which boosts NAD+ levels and promotes cellular health. In this review, we will examine Lovita NMN supplements and evaluate their effectiveness, quality, and safety.\nLovita NMN supplements contain β-Nicotinamide Mononucleotide, a precursor to NAD+, which has been shown to boost NAD+ levels in the body. The supplement also contains Resveratrol, a natural polyphenol found in red grapes known for its anti-aging properties. The supplement is made with common excipients used in the production of supplements such as Hydroxypropyl Methylcellulose (HPMC), Microcrystalline Cellulose, Magnesium Stearate, and Silicon Dioxide.\nLovita NMN supplements are manufactured and tested in a cGMP, HACCP and FDA registered facility located in California. This ensures that the product meets the highest standards of quality and safety. Additionally, Lovita NMN supplements are Halal certified making them suitable for consumers who follow a Halal diet.\nLovita offers three types of NMN supplements with different doses: NMN 12000 containing 12000mg of NMN; NMN 18000 containing 18000mg of NMN; and NMN 38000 containing 38000mg of NMN. Each type contains 60 capsules with recommended dosage for enhanced results being two capsules per day taken with food. To check exact amount of NMN and Resveratrol present in each supplement container check the supplement facts label below:\nSeveral studies have shown that supplementation with NMN increases NAD+ levels in the body resulting in promoting cellular health and improving overall wellbeing. In mice studies published in Cell Metabolism journal in 2016, it was found that supplementation with NMN improved insulin sensitivity, increased energy metabolism, and enhanced muscle function. Although there is limited research on the effectiveness of supplementation with NMN in humans early studies have shown promising results.\nLovita NMN supplements are manufactured under strict guidelines at a cGMP, HACCP and FDA registered facility located in California ensuring highest standards of quality and safety. Additionally, since it is Halal certified it is suitable for wider range of consumers. The supplement contains high-quality ingredients such as β-Nicotinamide Mononucleotide and Resveratrol both known to promote cellular health besides having anti-aging properties.\nLovita NMN supplements are generally well-tolerated without any reported side effects so far. However like all other dietary supplements it is important to consult healthcare provider before starting any new supplement especially if you have pre-existing medical conditions or taking prescription medication.\n- Contains high dose of β-Nicotinamide Mononucleotide which has been shown to boost NAD+ levels resulting in promoting cellular health.\n- Manufactured under strict guidelines at cGMP,HACCP,FDA registered facility located at California ensuring highest standards of quality & safety.\n- Suitable for wider range of consumers due to its Halal certification.\n- Contains Resveratrol which has anti-aging properties.\n- More expensive than other available products on market.\n- Limited research on effectiveness & further studies required to confirm benefits..\nWhat is NMN?\nNMN is a precursor to NAD+, a molecule that is essential for maintaining cellular health and promoting overall wellbeing.\nWhat is the recommended dosage for Lovita NMN supplements?\nThe recommended dosage of Lovita NMN supplements is two capsules per day, taken with food.\nAre there any side effects associated with Lovita NMN supplements?\nThere have been no reported side effects associated with Lovita NMN supplements. However, it is advisable to consult with a healthcare provider before starting to take the supplement, especially if you have an underlying medical condition or are taking medication.\nHow are Lovita NMN supplements different from other NMN supplements on the market?\nLovita NMN supplements contain a high dose of NMN and are manufactured in a cGMP, HACCP, and FDA registered facility in California, ensuring the highest standards of quality and safety. Additionally, the supplement is Halal certified, making it suitable for a wider range of consumers.\nAre Lovita NMN supplements vegan-friendly?\nYes, Lovita NMN supplements are vegan-friendly as they do not contain any animal products or by-products.\nCan Lovita NMN supplements be taken with other supplements or medications?\nIt is always advisable to consult with a healthcare provider before taking any new supplement or medication together as there may be interactions between them.\nHow long does it take to see the effects of Lovita NMN supplements?\nThe effects of Lovita NMN supplements may vary from person to person depending on their current health status. Some individuals may notice improvements in energy levels and overall wellbeing within a few weeks while others may take longer. Consistent intake and adherence to the recommended dosage can maximize its benefits.\nAre Lovita NMN supplements suitable for pregnant or breastfeeding women?\nPregnant or breastfeeding women should consult with their healthcare provider before taking any new supplement including Lovita MNM Supplements.", "domain": "chemistry", "round": 3} +{"url": "https://www.gulfoilandgas.com/webpro1/main/mainnews.asp?id=45041", "date": "2022-08-08T06:59:00Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882570767.11/warc/CC-MAIN-20220808061828-20220808091828-00005.warc.gz", "language_score": 0.9180433750152588, "token_count": 625, "dump": "CC-MAIN-2022-33", "global_id": "webtext-fineweb__CC-MAIN-2022-33__0__72337146", "lang": "en", "text": "Petroliam Nasional Berhad (PETRONAS), Malaysia’s national oil and gas company has selected Axens as a technology provider for PETRONAS’ Refinery and Petrochemicals Integrated Development (RAPID) project located in Pengerang, Johor, Malaysia.\nRAPID is part of PETRONAS’ Pengerang Integrated Complex (PIC) development, which includes six major associated facilities namely the Pengerang Co-generation Plant, Re-gasification Terminal 2, Air Separation Unit, Raw Water Supply Project, Liquid Bulk Terminal as well as central and shared Utilities and Facilities.\nDeveloped within a 6,242 acres site in Pengerang, Johor, PIC forms part of the Johor State’s Pengerang Integrated Petroleum Complex (PIPC), which is under Malaysia’s Economic Transformation Programme (ETP) to establish new engines of growth for Malaysia; whilst meeting future energy requirement and strengthening PETRONAS’ position as a key player in the Asian chemicals market, focusing on differentiated and specialty chemicals. RAPID is estimated to cost US$16 billion while the associated facilities will involve an investment of about US$11 billion. PIC is poised for its refinery start-up by early 2019.\nAxens was initially selected in October 2010 for a Detailed Feasibility Study, after which their technologies were selected following an open bid in January 2012 on the basis of the best NPV (Net Present Value), as well as proven long term operating experiences supported by the technology and catalyst’s specific features; hence providing additional benefits to the project. The following technologies from Axens was selected for the RAPID project:\n- Naphtha Hydrotreating (NHT), this process purifies naphtha removing dienes, olefins compounds, sulfur and nitrogen species with a feed capacity of 21,000 BPSD;\n- OctanizingTM a continuous catalytic regenerative (CCR) reforming process for maximizing the production of reformate from heavy hydrotreated naphtha , with a feed capacity of this unit 14,000 BPSD;\n- Prime-KTMa catalytic process achieving hydrotreatment of a kerosene cut, with smoke point improvement and deep desulfurization, its feed capacity is 30,000 BPSD;\n- R2RTMa residue fluidized catalytic cracking (RFCC) process including a double regenerator which enable to crack residue feedstock or vacuum gas-oil into lighter hydrocarbons. The process also includes a propylene recovery section (PRU Section). The capacity of the RFCC unit is 140,000 BPSD of feedstock in two trains;\n- Prime G+TMcatalytic process aiming at desulphurizing FCC gasoline while minimizing the octane loss. It includes a selective hydrogenation reactor/splitter and hydrodesulphurization reactor/stabilizer. The feed capacity of this unit is 75,000 BPSD.", "domain": "chemistry", "round": 3} +{"url": "https://essentialwholesale.com/cocamidopropyl-betaine", "date": "2022-01-25T11:37:06Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-05/segments/1642320304810.95/warc/CC-MAIN-20220125100035-20220125130035-00262.warc.gz", "language_score": 0.8884844779968262, "token_count": 272, "dump": "CC-MAIN-2022-05", "global_id": "webtext-fineweb__CC-MAIN-2022-05__0__218513332", "lang": "en", "text": "Cocoamidopropyl Betaine, is a fairly mild and gentle surfactant used in melt and pour soaps...\nProcessing: Naturally derived.\nParts Used: Coconut oil.\nCountry of Origin: USA\nAlternate Names: coco betaine\nIngredient Function: Surfactant\nRecommended Usage Rate: 1% - 40%\nSolubility: Soluble in water.\nWarnings: Normal safety precautions (i.e., gloves and safety goggles) should be employed when handling surfactants. Contact with the eyes and prolonged contact with the skin should be avoided. Wash thoroughly after handling material. Immediately flush eyes with plenty of water for 15 minutes.\nNot for internal consumption. For external use only.\nPregnant or lactating people or those with known medical conditions should consult with a physician prior to using product.\nPlease note that our suggested usage instructions are intended to serve as a guide. Due to the unique nature of each ingredient, it is important to always research and consult with a qualified professional as needed, prior to use. Usage guidelines can change and you are responsible for adhering to local regulations. EWL cannot be held responsible for any harm caused due to the misuse of these ingredients.", "domain": "chemistry", "round": 3} +{"url": "https://www.accessscience.com/content/gas-field-and-gas-well/280900", "date": "2021-09-27T07:43:53Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-39/segments/1631780058373.45/warc/CC-MAIN-20210927060117-20210927090117-00166.warc.gz", "language_score": 0.8777161240577698, "token_count": 429, "dump": "CC-MAIN-2021-39", "global_id": "webtext-fineweb__CC-MAIN-2021-39__0__240239054", "lang": "en", "text": "Gas field and gas well\nDoscher, Todd M. Formerly, Department of Petroleum Engineering, University of Southern California, Los Angeles, California.\nLast reviewed:January 2020\n- Related Primary Literature\n- Additional Reading\nThe term gas field refers to a geographical area which is underlain by one or more commercial reservoirs of petroleum. This commercially valuable gas, primarily methane but with smaller amounts of ethane, propane, and butanes and in some cases containing significant concentrations of carbon dioxide, hydrogen sulfide, and nitrogen, is produced through wells which penetrate subterranean reservoirs, composed of porous rock. The gas in the reservoir may be free or dissolved in crude oil.\nThe content above is only an excerpt.\nfor your institution. Subscribe\nTo learn more about subscribing to AccessScience, or to request a no-risk trial of this award-winning scientific reference for your institution, fill in your information and a member of our Sales Team will contact you as soon as possible.\nto your librarian. Recommend\nLet your librarian know about the award-winning gateway to the most trustworthy and accurate scientific information.\nAccessScience provides the most accurate and trustworthy scientific information available.\nRecognized as an award-winning gateway to scientific knowledge, AccessScience is an amazing online resource that contains high-quality reference material written specifically for students. Contributors include more than 10,000 highly qualified scientists and 46 Nobel Prize winners.\nMORE THAN 8700 articles covering all major scientific disciplines and encompassing the McGraw-Hill Encyclopedia of Science & Technology and McGraw-Hill Yearbook of Science & Technology\n115,000-PLUS definitions from the McGraw-Hill Dictionary of Scientific and Technical Terms\n3000 biographies of notable scientific figures\nMORE THAN 19,000 downloadable images and animations illustrating key topics\nENGAGING VIDEOS highlighting the life and work of award-winning scientists\nSUGGESTIONS FOR FURTHER STUDY and additional readings to guide students to deeper understanding and research\nLINKS TO CITABLE LITERATURE help students expand their knowledge using primary sources of information", "domain": "chemistry", "round": 3} +{"url": "http://www.innovations-report.com/html/reports/earth-sciences/hydrocarbons-deep-earth-174051.html", "date": "2016-10-24T21:59:19Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2016-44/segments/1476988719784.62/warc/CC-MAIN-20161020183839-00414-ip-10-171-6-4.ec2.internal.warc.gz", "language_score": 0.9034711122512817, "token_count": 1152, "dump": "CC-MAIN-2016-44", "global_id": "webtext-fineweb__CC-MAIN-2016-44__0__147804696", "lang": "en", "text": "Hydrocarbon molecules are the main building blocks of crude oil and natural gas, and determining their thermochemical properties is important to understand carbon reservoirs and fluxes in the Earth.\nGeologists and geochemists believe that nearly all of the hydrocarbons in commercially produced crude oil and natural gas are formed by the decomposition of the remains of living organisms buried under layers of sediments in the Earth's crust, a region that extends five to 10 miles below the Earth's surface.\nBut \"abiogenic\" hydrocarbons of purely chemical deep crustal or mantle origin could occur in some geologic settings, such as rifts or subduction zones, said Giulia Galli, professor of chemistry and of physics at UC Davis and senior author on the study.\n\"Our simulation study shows that methane molecules can combine to form larger hydrocarbon molecules when exposed to the very high temperatures and pressures of the Earth's upper mantle. We don't say that higher hydrocarbons actually occur under the realistic 'dirty' Earth mantle conditions, but the pressures and temperatures are right,\" she said.\nGalli and her colleagues used the University of California's Mako computer cluster in Berkeley and computers at the Lawrence Livermore National Laboratory to simulate the behavior of carbon and hydrogen atoms at the enormous pressures and temperatures found 40 to 95 miles deep inside the Earth.\nThey used sophisticated techniques based on first principles (the basic properties of carbon and hydrogen atoms) and the computer software system Qbox, developed at UC Davis by Francois Gygi, a professor in the Department of Computer Science.\nThe researchers found that hydrocarbons with multiple carbon atoms can form from methane, (a molecule with only one carbon and four hydrogen atoms) at temperatures greater than 1,500 K (2,240 degrees F) and pressures 50,000 times those at the Earth's surface, conditions found about 70 miles below the surface.\n\"In the simulation, interactions with metal or carbon surfaces allowed the process to occur faster; they act as 'catalysts',\" said Leonardo Spanu, assistant researcher at UC Davis and the first author of the paper.\nThe research does not address whether hydrocarbons formed that deep in the Earth could migrate closer to the surface and contribute to exploitable oil or gas deposits. However, the study is fundamentally important because it points to possible microscopic mechanisms of hydrocarbon formation under very high temperatures and pressures.\nGalli and some of her collaborators at UC Davis are part of a larger project, the Deep Carbon Observatory, supported by the Alfred P. Sloan Foundation; Galli is co-chair of the observatory's Physics and Chemistry of Carbon directorate. The aim of the observatory is to study the Earth's carbon cycle, including the presence of hydrocarbons and the possibility of microbial life deep in the planet.\nGalli's co-authors are Davide Donadio at the Max Planck Institute in Mainz, Germany; Detlef Hohl at Shell Global Solutions, Houston; and Eric Schwegler, Lawrence Livermore National Laboratory.\nThe research was supported by Shell.\nAndy Fell | EurekAlert!\nOasis of life in the ice-covered central Arctic\n24.10.2016 | Alfred-Wegener-Institut, Helmholtz-Zentrum für Polar- und Meeresforschung\nReceding glaciers in Bolivia leave communities at risk\n20.10.2016 | European Geosciences Union\nTerahertz excitation of selected crystal vibrations leads to an effective magnetic field that drives coherent spin motion\nControlling functional properties by light is one of the grand goals in modern condensed matter physics and materials science. A new study now demonstrates how...\nResearchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.\n\"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits,\" said Jeremy Béjanin, a PhD...\nIn a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.\nA research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...\nBy forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.\n\"People have already built small quantum computers,\" says Sandia researcher Ryan Camacho. \"Maybe the first useful one won't be a single giant quantum computer...\nCOMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.\nIn 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...\n14.10.2016 | Event News\n14.10.2016 | Event News\n12.10.2016 | Event News\n24.10.2016 | Earth Sciences\n24.10.2016 | Life Sciences\n24.10.2016 | Physics and Astronomy", "domain": "chemistry", "round": 3} +{"url": "https://www.safetyclasses.ca/online-course/flammable-liquid-safety-online-course/", "date": "2023-09-23T04:52:34Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233506479.32/warc/CC-MAIN-20230923030601-20230923060601-00358.warc.gz", "language_score": 0.8773016929626465, "token_count": 409, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__163285391", "lang": "en", "text": "FLAMMABLE LIQUID SAFETY COURSE OVERVIEW\nAccording to the National Fire Protection Association (NFPA), around 1,400 fires occur annually in which flammable or combustible liquids were first ignited. Direct property damage is approximately $76 million dollars each year.\nAs you can see, flammable liquids must be handled with care. Upon successful completion of this course, you should be able to:\n- Describe the characteristics of flammable liquids\n- Recognize hazards inherent with work involving flammable liquids\n- Identify the safety requirements for the use of flammable liquids on the job\n- Recognize the storage requirements for flammable liquids at a work facility\n- Describe the principles of flashpoint protection when working with flammable liquids\n- Demonstrate the steps for inspecting inventories of flammable liquids in the workplace\nThis course was designed to help satisfy requirements of the following regulations:\n- 29 CFR 1910.106 Flammable Liquids, Subpart H, “Hazardous Materials”\n- 29 CFR 1910. 1200, “Hazard Communication”\nFLAMMABLE LIQUID SAFETY COURSE TOPICS\n- How to identify flammable liquids\n- Hazard recognition\n- Safety requirements\n- Flashpoint protection\n- Inventory inspections\nFLAMMABLE LIQUID SAFETY COURSE DURATION:\nApproximately 40 minutes\nFLAMMABLE LIQUID SAFETY COURSE ASSESSMENT:\nTesting conducted throughout this online course is designed to reinforce the information presented. A mark of 80% must be achieved in order to receive a certificate of completion. Users are able to repeat the course twice if the pass mark is not achieved.\nFLAMMABLE LIQUID SAFETY CERTIFICATE OF COMPLETION:\nUpon successful completion of this online course, a certificate of completion will be available for download and printing.", "domain": "chemistry", "round": 3} +{"url": "http://www.hrpworld.com/red-30604-red-line-racing-synthetic-c-atf-qt.html", "date": "2019-09-19T17:02:15Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-39/segments/1568514573561.45/warc/CC-MAIN-20190919163337-20190919185337-00340.warc.gz", "language_score": 0.768248975276947, "token_count": 539, "dump": "CC-MAIN-2019-39", "global_id": "webtext-fineweb__CC-MAIN-2019-39__0__149677464", "lang": "en", "text": "C+ATF - quart\nRED LINE SYNTHETIC AUTOMATIC TRANSMISSION LUBRICANTS\nRED LINE SYNTHETIC ATF - Synthetic Dexron II, Mercon, and Mercedes-Benz approved fluid. Superior stability allows high-temperature operation without varnishing valves and clutches. Also provides improved shifting in cold weather.\nRED LINE D4 ATF - Synthetic Dexron III and Mercon fluid meeting the requirements of most transmission manufacturers, while satisfying GL-4 gear oil requirements. Superior stability allows high-temperature operation without varnishing valves and clutches. Also provides tremendously improved shifting in cold weather. The best low-temperature shiftability for manual transmissions and transaxles which require ATFs.\nRED LINE HIGH-TEMP ATF - Synthetic ATF which is a GL-4 gear oil for use where Dexron III or Mercon is recommended. A higher viscosity allows optimal operation at 70°F higher temperature, providing better torque converter efficiency. Perfect for heavily-loaded vehicles. Superior stability allows high-temperature operation without varnishing valves and clutches.\nRED LINE RACING ATF - Synthetic ATF for automatic and manual transmissions which need the positive shift of a TYPE-F ATF. This ATF contains no slipperiness additives, producing faster shifts and quicker lock-up. A higher viscosity at high temperatures provides greater efficiency and provides better wear protection than other ATFs.\nRED LINE C+ ATF - Satisfies the performance requirements of Chrysler Types 7176 and ATF+4 (Type 9602), while providing 30% greater operating viscosity, 1/3 the evaporation of petroleum ATFs, and improved oxidation and sludge protection. Red Line C+ ATF provides the exact frictional characteristics required in the Type 7176 specification, providing proper shift feel and proper lockup torque converter operation. The use of an improper fluid could cause torque converter shudder or harsh shifting. Red Line C+ ATF also provides the best low-temperature shiftability in automatic transmissions allowing proper shifting at extremely low temperatures and will flow down to temperatures as low as -60°C. The improved wear protection makes C+ ATF the perfect automatic transmission or transaxle fluid for Chrysler vehicles.\n|Alternative Part Number 1||- None -|\n|Alternative Part Number 2||- None -|\n|Alternative Part Number 3||- None -|\n|Alternative Part Number 4||- None -|\n|Alternative Part Number 5||- None -|\n|Alternative Part Number 6||- None -|\n|Alternative Part Number 7||- None -|", "domain": "chemistry", "round": 3} +{"url": "http://www.elsevier.com/books/advances-in-agronomy/sparks/978-0-12-000747-9", "date": "2015-10-10T16:13:02Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2015-40/segments/1443737958671.93/warc/CC-MAIN-20151001221918-00146-ip-10-137-6-227.ec2.internal.warc.gz", "language_score": 0.8258874416351318, "token_count": 375, "dump": "CC-MAIN-2015-40", "global_id": "webtext-fineweb__CC-MAIN-2015-40__0__64681402", "lang": "en", "text": "Advances in Agronomy\n- Donald L Sparks, S.Hallock du Pont Chair in Soil and Environmental Chemistry and Director, Delaware Environmental Institute, University of Delaware, Newark, DE, USA\nUnder new editorial direction, Advances in Agronomy both continues its long tradition and expands to include innovative methods and technologies. Leading international scientists cover topics in plant and soil sciences, biotechnology, terrestrial ecosystems, and environmental concerns.The second volume under new editorial direction, Advances in Agronomy, Volume 47 focuses on environmental quality and biotechnology. Four articles on soil science cover acid deposition, chemical transport, and surface complexation. Two articles on crop science survey variety fingerprinting and corn evolution. This and related volumes will be of interest to agronomists and biotechnologists in academe, industry, and government.View full description\nResearchers and students in agronomy, crop and soil science, environmental science, molecular biology and genetics, biotechnology, agricultural engineering, botany, horticulture, and forestry.\n- Published: March 1992\n- Imprint: ACADEMIC PRESS\n- ISBN: 978-0-12-000747-9\nTable of ContentsW.P. Robarge and D.W. Johnson, The Effects of Acidic Deposition on Forested Soils.J.S.C. Smith and O.S. Smith, Fingerprinting Crop Varieties.W.A. Jury and H. Fladuhler, Transport of Chemicals through Soils: Mechanisms, Models, and Field Applications.W.C. Galinat, Evolution of Corn.S. Goldberg, Use of Surface Complexation Models in Soil Chemical Systems.H.M. Selim, Modeling The Transport and Retention of Inorganics in Soils.Index.", "domain": "chemistry", "round": 3} +{"url": "http://www.reinventarlasorganizacioneswiki.com/index.php?title=6)._Curiously,_atrazine_exposure_has_become_described_to_minimize_cancer_by_suppressing&diff=814204&oldid=0", "date": "2019-12-13T16:53:26Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-51/segments/1575540564599.32/warc/CC-MAIN-20191213150805-20191213174805-00257.warc.gz", "language_score": 0.8777478337287903, "token_count": 906, "dump": "CC-MAIN-2019-51", "global_id": "webtext-fineweb__CC-MAIN-2019-51__0__115691600", "lang": "en", "text": "Diferencia entre revisiones de «6). Curiously, atrazine exposure has become described to minimize cancer by suppressing»\n(Página creada con «The [https://www.medchemexpress.com/3-Deazaneplanocin-A-hydrochloride.html 3-Deazaneplanocin A In stock] effects of atrazine on feminine reproductive health and fitness hav...»)\nRevisión actual del 18:55 4 dic 2019\nThe 3-Deazaneplanocin A In stock effects of atrazine on feminine reproductive health and fitness have been extensively analyzed with publicity becoming involved with deregulated sterodoigenesis and angiogenesis (215). Evidence that exposure of hepatocytes to diisononyl phthalate raises proliferation, palmitoylCoA oxidase action, and levels of enzymes concerned in and oxidation of essential fatty acids dependent on a further nuclear receptor, PPAR, assist results on metabolic 2-Deoxy-D-glucose SDS process (214). These results advise that phthalates may act on tumor growth by disrupting vital crosstalk amongst TGF and ER indicators resulting in evasion of antigrowth indicators. Moreover, exposure of human oropharangeal and nasal mucosa cells for the phthalates dinbuthyl phthalate and diisobutyl phthalate will increase DNA strand breaks as well as chance of increasing genetic instability (253). Just like several environmental chemical compounds, phthalates exhibit a big selection of the two anticarcinogenic and carcinogenic things to do. Such as, phthalate esters induce apoptosis in bovine testicular pluripotent stemFuture directionsWhile there exists obviously intriguing proof for the part of environmental chemical compounds to work as immune disruptors, there exists a massive paucity of information for how these consequences around the immune process would ultimately influenc.6). Curiously, atrazine publicity has actually been noted to lower most cancers by suppressing prostate carcinogenesis via metabolic deregulation that manifests as bodyweight reduction (209). In distinction, atrazine reveals carcinogenic results by endorsing obesity and insulin resistance by blocking the actions of oxidative phosphorylation complexes I and III (210). The effects of atrazine on female reproductive health and fitness are thoroughly analyzed with publicity staying associated with deregulated sterodoigenesis and angiogenesis (215). There are no research specifically addressing anticancer hallmark homes, but a variety of scientific tests have demonstrated that triazine derivatives suppress replicative immortality (229,257,258). For effects on inflammation, the proposed goal molecule is TNF (19799). An extensive body of work on TNF supports its position in endorsing evasion of antigrowth signals (158,19396,20002,259,260), advertising of angiogenesis (196), immediate effects on selling myeloid suppressors mobile and tumor immune method evasion (unpublished facts) replicative immortality (163), and sustained proliferative signalling (200,260). On top of that, TNF encourages epithelial to mesenchymal transition and tumor invasiveness in breast and colon most cancers cell lines (20103) too as alters the neighborhood metabolic and microenvironment which include advertising tumorassociated fibroblasts (seven,193).PhthalatesPhthalates are already proven to act over a number of the cancer hallmarks, while we identified no reports investigating effects on replicative immortality or tumor microenvironment. Evidence that publicity of hepatocytes to diisononyl phthalate boosts proliferation, palmitoylCoA oxidase activity, and amounts of enzymes included in and oxidation of essential fatty acids depending on an additional nuclear receptor, PPAR, help results on metabolic rate (214). Moreover, benzyl butyl phthalate, a standard plasticizer use in manufacturing polyvinyl chloride and acknowledged developmental toxicant, has long been shown to increase angiogenesis in vivo (238,249). Phthalates have already been documented to advertise tumor development and invasion of most cancers cells in vitro via regulation of cyclin D, PPAR and AhR (231,232,250). Immediate outcomes of phthalates on p53 happen to be proposed that will guidance results of phthalates on evasion of antigrowth indicators, while that is controversial (251,252). A current examine by Lee et al.", "domain": "chemistry", "round": 3} +{"url": "https://forschung.fh-ooe.at/en/timed/timed-center/research/projects/projects/news/sesam-1/", "date": "2023-11-28T19:39:02Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679099942.90/warc/CC-MAIN-20231128183116-20231128213116-00151.warc.gz", "language_score": 0.9171239137649536, "token_count": 347, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__144003662", "lang": "en", "text": "TIMed CENTER Center for Technological Innovation in Medicine\nTarget: Development of self-learning search algorithms for high-resolution mass spectra.\nUsually, mass spectrometry is used to identify proteins in biological samples. In the interdisciplinary bioinformatics-project SESAM, a research group at the faculty in Hagenberg develops a series of new idenfication algorithms. These algorithms are specifically designed for the analysis of such mass spectra and respect various information sources.\nThe first research results give an understanding of the wide range of opportunities: One project about the analysis of mass spectra has been completed already. An innovative scoring-function that was developed by the research group bioinformatics of the University of Applied Sciences Upper Austria at the campus Hagenberg in cooperaton with the research group for proteomics of the IMP in Vienna provides remarkable identification rates. These are not only similar to the ones of Mascot, the current standard method in the identification of mass spectra, but sometimes even higher.\nAll results that are about to be drawn from this research projects are intended to be made available to both the bioinformatics- and proteomics-community. It is expected that the identification rates of peptides in general as well as of unknown modifications in particular, which are about to be improved by means of informatics, will grant a better insight into the proteome.\n- Head: FH-Prof. PD DI Dr. Stephan Winkler\n- Funding Program: FWF (Translational Research)\n- Duration: seit 03/2013\n- Faculty: Hagenberg\nPlease find a selection of papers published about this project by clicking on the following link.", "domain": "chemistry", "round": 3} +{"url": "https://link.springer.com/article/10.1007%2Fs11094-019-1909-7", "date": "2019-01-18T16:16:35Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-04/segments/1547583660175.18/warc/CC-MAIN-20190118151716-20190118173716-00458.warc.gz", "language_score": 0.6760073900222778, "token_count": 646, "dump": "CC-MAIN-2019-04", "global_id": "webtext-fineweb__CC-MAIN-2019-04__0__210466801", "lang": "en", "text": "Synthesis and Pharmacological Properties of Adamantane-Containing Bis-Cationic Compounds\n- 33 Downloads\nThe bis-cationic compound 1-amino-4-(1-adamantanamino)butane dihydrochloride (IEM-1913) has important advantages over clinically employed monocationic 3,5-dimethyl-1-aminoadamantane (memantine) because its anticonvulsant activity is significantly greater and its therapeutic index is 814 times higher than that of memantine. 1-Amino-4-(3,5-dimethyl-1-adamantanamino)butane dihydrochloride (IEM-2127) and 1-amino-6-(3,5-dimethyl-1-adamantanamino)hexane dihydrochloride (IEM-2121) have anticonvulsant activity equal to that of memantine although their therapeutic indices are 94.9 and 88.6 times, respectively, greater than that of memantine. IEM-1913 causes statistically significant anticonvulsant effects in the dose range 0.03 – 0.3 mg/kg; IEM-2127 and IEM-2121, in the dose range 0.1 – 1.0 mg/kg, in contrast with memantine, which is effective only at a single maximum dose of 15 – 20 mg/kg. The high anticonvulsant activity and low toxicity of IEM-1913, IEM-2121, and IEM-2127 are explained by the fact that these bis-cationic compounds cause combined blocking of NMDA and AMPA brain receptors, in contrast with monocationic selective NMDA-blocker memantine.\nKeywordsmemantine IEM-1913 IEM-2121 IEM-2127 seizures\n- 1.S. I. Gavrilova, Psikhiatr. Psikhofarmakoter., 7(2), 72 – 76 (2005).Google Scholar\n- 12.V. E. Gmiro and S. E. Serdyuk, Byull. Eksp. Biol. Med., 145(6), 675 – 677 (2008); V. E. Gmiro and S. E. Serdyuk, Bull. Exp. Biol. Med., 145(6), 728 – 730 (2008).Google Scholar\n- 14.V. E. Gmiro, S. E. Serdyuk, and O. S. Veselkina, Byull. Eksp. Biol. Med., 160(7), 80 – 83 (2015); V. E. Gmiro, S. E. Serdyuk, and O. S. Veselkina, Bull. Exp. Biol. Med., 160(1), 68 – 71 (2015).Google Scholar\n- 15.A. N. Mironov (ed.), Handbook for Preclinical Drug Trials [in Russian], Grif i K, Moscow (2012).Google Scholar", "domain": "chemistry", "round": 3} +{"url": "https://elar.urfu.ru/handle/10995/102832", "date": "2022-10-04T17:27:49Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-40/segments/1664030337516.13/warc/CC-MAIN-20221004152839-20221004182839-00084.warc.gz", "language_score": 0.7624333500862122, "token_count": 980, "dump": "CC-MAIN-2022-40", "global_id": "webtext-fineweb__CC-MAIN-2022-40__0__74635239", "lang": "en", "text": "Please use this identifier to cite or link to this item:\n|Title:||Effect of Ag2O substituted in bioactive glasses: a synergistic relationship between antibacterial zone and radiation attenuation properties|\n|Authors:||Tekin, H. O.|\nAl-Buriahi, M. S.\nIssa, S. A. M.\nZakaly, H. M. H.\nKarim, M. K. A.\nMatori, K. A.\nZaid, M. H. M.\n|Publisher:||Elsevier Editora Ltda|\n|Citation:||Effect of Ag2O substituted in bioactive glasses: a synergistic relationship between antibacterial zone and radiation attenuation properties / H. O. Tekin, M. S. Al-Buriahi, S. A. M. Issa, et al. — DOI 10.1016/j.jmrt.2021.06.025 // Journal of Materials Research and Technology. — 2021. — Vol. 13. — P. 2194-2201.|\n|Abstract:||In this study, a promising relationship between antibacterial zone and radiation attenuation properties was investigated in Ag2O doped bioactive glasses with a chemical composition of xAg2O–20Li2O–25TeO2-(55-x)B2O3 (where x = 0, 0.5, 1.0, 1.5, and 2.0 mol%). For this aim, a wide-ranging radiation attenuation characterization procedure was performed on Ag2O substituted bioactive glasses. The general-purpose Monte Carlo code MCNPX (v.2.7.0) was used to model bioactive glasses. The mass attenuation coefficients were calculated using a gamma-ray transmission setup. The coefficients obtained were used to determine other important attenuation properties. Finally, for particular behaviors, exposure (EBF) and energy absorption (EABF) build-up factors were calculated for specific attitudes of Ag2O substitutions in bioactive glasses during the interaction process. The results showed that there is direct relationship between Ag2O substitution amount and radiation attenuation properties. In addition to its well-behaviors on inhibition zone against bacterial occurrences, it can be concluded that increasing Ag2O would increase the gamma-ray attenuation properties of studied bioactive glass system. © 2021 The Authors|\n|metadata.dc.description.sponsorship:||The authors thank for the scholar and research grant under Universiti Putra Malaysia , Taif University Researchers Supporting Project number (TURSP-2020/12), Taif University , Saudi Arabia and Deanship of Scientific Research at King Khalid University for financial support through General Research Project under grant number ( G.R.P/81/42 ).|\n|Appears in Collections:||Научные публикации, проиндексированные в SCOPUS и WoS CC|\nItems in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.", "domain": "chemistry", "round": 3} +{"url": "https://www.creativebiomart.net/description_21305_10.htm", "date": "2019-12-11T14:20:09Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-51/segments/1575540531917.10/warc/CC-MAIN-20191211131640-20191211155640-00371.warc.gz", "language_score": 0.8211106061935425, "token_count": 358, "dump": "CC-MAIN-2019-51", "global_id": "webtext-fineweb__CC-MAIN-2019-51__0__165759607", "lang": "en", "text": "|Cat. No. :\n|Product Overview :\n||Recombinant human NTF4 protein was expressed in E.coli (81-210 aa).\n||NTF4, also known as neurotrophin 4, is a member of a family of neurotrophic factors neurotrophins that control survival and differentiation of mammalian neurons. This protein is ubiquitous and less influenced by environmental signals. While knock-outs of other neurotrophins including nerve growth factor, brain-derivedneurotrophic factor, and neurotrophin 3 prove lethal during early postnatal development, NTF4-deficient mice only show minor cellular deficits and develop normally to adulthood.\n||Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.4M Urea, 20% glycerol\n|Molecular Weight :\n||14.1 kDa (131aa)\n||> 85% by SDS - PAGE\n||1 mg/ml (determined by Bradford assay)\n|Sequences of amino acids :\n||MGVSETAPAS RRGELAVCDA VSGWVTDRRT AVDLRGREVE VLGEVPAAGG SPLRQYFFET RCKADNAEEG GPGAGGGGCR GVDRRHWVSE CKAKQSYVRA LTADAQGRVG WRWIRIDTAC VCTLLSRTGR A\n||Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.\n||MAPK signaling pathway; Neurotrophin signaling pathway", "domain": "chemistry", "round": 3} +{"url": "https://www.nature.com/articles/s41428-022-00705-0?error=cookies_not_supported&code=eaea5872-9ef6-4524-932e-0b0070c9f0a5", "date": "2023-03-26T02:13:46Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-14/segments/1679296945381.91/warc/CC-MAIN-20230326013652-20230326043652-00602.warc.gz", "language_score": 0.7060997486114502, "token_count": 3059, "dump": "CC-MAIN-2023-14", "global_id": "webtext-fineweb__CC-MAIN-2023-14__0__85948977", "lang": "en", "text": "The conformational changes of molecular chains in a polymer significantly affect the hydrophobicity, biocompatibility, and stimuli responsiveness. Herein, the folding behavior of a poly(2-dimethylaminoethyl methacrylate) (PDMAEMA) surrounded by water molecules was evaluated using molecular dynamics simulations over a wide temperature range (280–360 K). The PDMAEMA chain was simplified as a linear 30 mer with alternately protonated side chains. The radius of gyration (Rg) of the 30 mer was calculated to confirm that it formed a globule state at higher temperatures; the Rg values diminished unexceptionally to ca. 10 Å at higher temperatures (≥320 K), indicating that the DMAEMA oligomer formed a globule structure above the previously reported lower critical solution temperature of a PDMAEMA gel (~308–313 K). Furthermore, radial distribution functions (RDFs) around the geometric center of the 30 mer were evaluated; they indicated that protonated amine groups surrounded the aggregated deprotonated amine groups in the globule state. The calculation of RDFs around the geometric center of a simplified oligomer chain described here is a highly reliable strategy for evaluating the folding behavior of stimuli-responsive polymer gels during coil-to-globule transitions at the molecular level.\nThis is a preview of subscription content, access via your institution\nSubscribe to this journal\nReceive 12 print issues and online access\n$259.00 per year\nonly $21.58 per issue\nRent or buy this article\nGet just this article for as long as you need it\nPrices may be subject to local taxes which are calculated during checkout\nVan Vlierberghe S, Dubruel P, Schacht E. Biopolymer-based hydrogels as scaffolds for tissue engineering applications: a review. Biomacromolecules 2011;12:1387–408.\nWard MA, Georgiou TK. Thermoresponsive Polymers for Biomedical Applications. Polymers 2011;3:1215–42.\nQiu Y, Park K. Environment-Sensitive Hydrogels for Drug Delivery. Adv Drug Deliv Rev. 2001;53:321–39.\nRoy D, Brooks WLA, Sumerlin BS. New Directions in Thermoresponsive Polymers. Chem Soc Rev. 2013;42:7214–43.\nKlouda L. Thermoresponsive hydrogels in biomedical applications: a seven-year update. Eur J Pharm Biopharm. 2015;97:338–49.\nWeissman JM, Sunkara HB, Tse AS, Asher SA. Thermally Switchable Periodicities and Diffraction from Mesoscopically Ordered Materials. Science. 1996;274:959–63.\nKobayashi J, Kikuchi A, Sakai K, Okano T. Cross-Linked Thermo Responsive Anionic Polymer-Grafted Surfaces to Separate Bioactive Basic Peptides. Anal Chem. 2003;75:3244–9.\nQin S, Geng Y, Discher DE, Yang S. Temperature-Controlled Assembly and Release from Polymer Vesicles of Poly(Ethylene Oxide)-Block-Poly(N-isopropylacrylamide). Adv Mater. 2006;18:2905–9.\nJohnson RP, Jeong YI, John JV, Chung CW, Kang DH, Selvaraj M, et al. Dual Stimuli-Responsive Poly(N-isopropylacrylamide)-b-Poly(L-Histidine) Chimeric Materials for the Controlled Delivery of Doxorubicin into Liver Carcinoma. Biomacromolecules. 2013;14:1434–43.\nHalperin A, Kröger M, Winnik FM. Poly(N-isopropylacrylamide) Phase Diagrams: Fifty Years of Research. Angew Chem Int Ed Engl. 2015;54:15342–67.\nNagase K, Yamato M, Kanazawa H, Okano T. Poly(N-Isopropylacrylamide)-Based Thermoresponsive Surfaces Provide New Types of Biomedical Applications. Biomaterials 2018;153:27–48.\nGohy JF, Antoun S, Jérôme R. PH-Dependent Micellization of Poly(2-Vinylpyridine)-Block-Poly((Dimethylamino)Ethylmethacrylate) Diblock Copolymers. Macromolecules 2001;34:7435–40.\nBütün V, Armes SP, Billingham NC. Synthesis and Aqueous Solution Properties of near-Monodisperse Tertiary Amine Methacrylate Homopolymers and Diblock Copolymers. Polymer 2001;42:5993–6008.\nPlamper FA, Schmalz A, Ballauff M, Müller AH. Tuning the Thermoresponsiveness of Weak Polyelectrolytes by pH and Light: Lower and Upper Critical-Solution Temperature of Poly(N,N-Dimethylaminoethyl Methacrylate). J Am Chem Soc. 2007;129:14538–9.\nSynatschke CV, Schallon A, Jérôme V, Freitag R, Müller AHE. Influence of Polymer Architecture and Molecular Weight of Poly(2-(Dimethylamino)Ethyl Methacrylate) Polycations on Transfection Efficiency and Cell Viability in Gene Delivery. Biomacromolecules 2011;12:4247–55.\nZhu C, Jung S, Luo S, Meng F, Zhu X, Park TG, et al. Co-Delivery of siRNA and Paclitaxel into Cancer Cells by Biodegradable Cationic Micelles Based on PDMAEMA-PCL-PDMAEMA Triblock Copolymers. Biomaterials 2010;31:2408–16.\nLee SB, Russell AJ, Matyjaszewski K. ATRP Synthesis of Amphiphilic Random, Gradient, and Block Copolymers of 2-(Dimethylamino)Ethyl Methacrylate and n-Butyl Methacrylate in Aqueous Media. Biomacromolecules 2003;4:1386–93.\nPlamper FA, McKee JR, Laukkanen A, Nykänen A, Walther A, Ruokolainen J, et al. Miktoarm Stars of Poly(Ethylene Oxide) and Poly(Dimethylaminoethyl Methacrylate): Manipulation of Micellization by Temperature and Light. Soft Matter. 2009;5:1812–21.\nLiu X, Ni P, He J, Zhang M. Synthesis and Micellization of pH/Temperature-Responsive Double-Hydrophilic Diblock Copolymers Polyphosphoester-Block-Poly[2-(Dimethylamino)Ethylmethacrylate] Prepared via ROP and ATRP. Macromolecules. 2010;43:4771–81.\nCai Y, Shen W, Wang R, Krantz WB, Fane AG, Hu X. CO2 Switchable Dual Responsive Polymers as Draw Solutes for Forward Osmosis Desalination. Chem Commun (Camb). 2013;49:8377–9.\nThavanesan T, Herbert C, Plamper FA. Insight in the Phase Separation Peculiarities of Poly (Dialkylaminoethyl Methacrylate)s. Langmuir 2014;30:5609–19.\nDu H, Wickramasinghe R, Qian X. Effects of Salt on the Lower Critical Solution Temperature of Poly (N-Isopropylacrylamide). J Phys Chem B 2010;114:16594–604.\nAlaghemandi M, Spohr E. Molecular Dynamics Investigation of the Thermo-Responsive Polymer Poly(N-isopropylacrylamide). Macromol Theory Simul. 2012;21:106–12.\nWalter J, Sehrt J, Vrabec J, Hasse H. Molecular Dynamics and Experimental Study of Conformation Change of Poly(N-isopropylacrylamide) Hydrogels in Mixtures of Water and Methanol. J Phys Chem B. 2012;116:5251–9.\nTucker AK, Stevens MJ. Study of the Polymer Length Dependence of the Single Chain Transition Temperature in Syndiotactic Poly(N‑isopropylacrylamide) Oligomers in Water. Macromolecules. 2012;45:6697–703.\nUmapathi R, Vepuri SB, Venkatesu P, Soliman ME. Comprehensive Computational and Experimental Analysis of Biomaterial toward the Behavior of Imidazolium-Based Ionic Liquids: An Interplay between Hydrophilic and Hydrophobic Interactions. J Phys Chem B. 2017;121:4909–22.\nNarang P, Vepuri SB, Venkatesu P, Soliman ME. An Unexplored Remarkable PNIPAM-Osmolyte Interaction Study: An Integrated Experimental and Simulation Approach. J Colloid Interfac Sci. 2017;504:417–28.\nMin SH, Kwak SK, Kim BS. Atomistic Simulation for Coil-to-Globule Transition of Poly(2-Dimethylaminoethyl Methacrylate). Soft Matter. 2015;11:2423–33.\nMin SH, Kwak SK, Kim BS. Atomistic Insight into the Role of Amine Groups in Thermoresponsive Poly(2-Dialkylaminoethyl Methacrylate)s. Polymer 2017;124:219–25.\nLee H, Son SH, Sharma R, Won YY. A Discussion of the PH-Dependent Protonation Behaviors of Poly(2-(Dimethylamino)Ethyl Methacrylate) (PDMAEMA) and Poly(Ethylenimine-ran-2-ethyl-2-oxazoline) (P(EI-r-EOz)). J Phys Chem B. 2011;115:844–60.\nCase DA, Cerutti DS, Cheatham III TE, Darden TA, Duke RE, Giese TJ, et al. AMBER 2016, University of California, San Francisco; 2016.\nWu Y, Tepper HL, Voth GA. Flexible Simple Point-Charge Water Model with Improved Liquid-State Properties. J Chem Phys. 2006;124:024503.\nNagumo R, Suzuki R, Miyake T, Furukawa H, Iwata S, Mori H. Molecular Dynamics Study of the Correlation between the Solvation Structures and the Antifouling Properties of Three Types of Betaine Moieties. J Chem Eng Jpn. 2017;50:333–8.\nNagumo R, Matsuoka T, Iwata S. Interactions between Acrylate/Methacrylate Biomaterials and Organic Foulants Evaluated by Molecular Dynamics Simulations of Simplified Binary Mixtures. ACS Biomater Sci Eng. 2021;7:3709–17.\nNagumo R, Omori K, Muraki Y, Iwata S, Mori H, Yamada H. Correlation between Macroscopic Diffusion Rates and Microscopic Interactions in Ethylene Glycol-Based Solvents. Ind Eng Chem Res. 2021;60:13368–76.\nHumphrey W, Dalke A, Schulten K. VMD: Visual Molecular Dynamics. J Mol Graph. 1996;14:33–38.\nHan D, Tong X, Boissiére O, Zhao Y. General Strategy for Making CO2-Switchable Polymers. ACS Macro Lett. 2012;1:57–61.\nSkandalis A, Selianitis D, Sory DR, Rankin SM, Jones JR, Pispas S. Poly(2-(Dimethylamino) Ethyl Methacrylate)-b-Poly(Lauryl Methacrylate)-b-Poly(Oligo Ethylene Glycol Methacrylate) Triblock Terpolymer Micelles as Drug Delivery Carriers for Curcumin. J Appl Polm Sci. 2022; https://doi.org/10.1002/app.52899.\nHadiouch S, Maresca M, Gigmes D, Machado G, Maurel-Pantel A, Frik S, et al. A Versatile and Straightforward Process To Turn Plastics into Antibacterial Materials. Polym Chem. 2022;13:69–79.\nThis work was supported by the Salt Science Research Foundation (grant no. 1811) and JSPS KAKENHI (grant no. 19K05120).\nConflict of interest\nThe authors declare no competing interests.\nPublisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.\nRights and permissions\nSpringer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.\nAbout this article\nCite this article\nNagumo, R., Nishikawa, K., Sato, A. et al. Molecular dynamics simulations of the folding structure of a thermoresponsive 2-dimethylaminoethyl methacrylate oligomer in the globule state. Polym J 55, 85–93 (2023). https://doi.org/10.1038/s41428-022-00705-0", "domain": "chemistry", "round": 3} +{"url": "https://syntides.com/product/s-ac-mag3-nhs/", "date": "2021-05-09T04:42:13Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-21/segments/1620243988955.89/warc/CC-MAIN-20210509032519-20210509062519-00617.warc.gz", "language_score": 0.737113356590271, "token_count": 380, "dump": "CC-MAIN-2021-21", "global_id": "webtext-fineweb__CC-MAIN-2021-21__0__212847863", "lang": "en", "text": "Product name: S-Ac-MAG3-NHS\nSynonym: S-Acetyl-MAG3-NHS Ester,NHS-S-acetyl-MAG3,\nCatalog #: 8604018\nMolecular Formula: C14H18N4O8S\nMolecular Weight: 402.38\nCompound ID: 10873111\nDescription: S-Ac-MAG3-NHS, a modified mercaptoacetyltriglycine (MAG3) chelator, which has acetyl S-protection and C-terminal derivitized with N-hydroxysuccinimide (NHS) ester for conjugation, has been used to radiolabel four small peptides, bovine pancreatic trypsin inhibitor, epidermal growth factor, human neutrophil elastase inhibitor and plasmin inhibitor, with 99mTc. The mercaptoacetyltriglycine (MAG3) chelator has been shown to stably complex technetium-99m (99mTc) for nuclear imaging and radiorhenium (186/188Re) for tumor radiation therapy studies. The bifunctional N-hydroxysuccinimidyl ester of MAG3 with S-acetyl protection (N-hydroxysuccinimidyl S-acetylmercaptoacetyltriglycinate (NHS-MAG3)) has been successfully used to covalently conjugate a MAG3 chelator to primary amine functionalized biomolecules. The use of NHS-S-acetyl-MAG3 may be a convenient method of radiolabeling peptides with 99mTc.\nUsage: For Scientific Research Use Only, Not for Human Use.", "domain": "chemistry", "round": 3} +{"url": "https://www.greenmedinfo.com/article/curcumin-has-neuroprotective-effect-focal-cerebral-ischemic-rats-preventing-bl", "date": "2021-06-25T00:20:18Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-25/segments/1623488560777.97/warc/CC-MAIN-20210624233218-20210625023218-00607.warc.gz", "language_score": 0.8791909217834473, "token_count": 409, "dump": "CC-MAIN-2021-25", "global_id": "webtext-fineweb__CC-MAIN-2021-25__0__161305520", "lang": "en", "text": "Neuroprotective effect of curcumin on focal cerebral ischemic rats by preventing blood-brain barrier damage.\nChemotherapy. 2010;56(1):60-5. Epub 2010 Mar 19. PMID: 17303117\nDepartment of Pharmacology, School of Pharmacy, Nanjing Medical University, Nanjing, 210029, China.\nCurcumin, a member of the curcuminoid family of compounds, is a yellow colored phenolic pigment obtained from powdered rhizome of C. longa Linn. Recent studies have demonstrated that curcumin has protective effects against cerebral ischemia/reperfusion injury. However, little is known about its mechanism. Disruption of the blood-brain barrier occurs after stroke. Protection of the blood-brain barrier has become an important target of stroke interventions in experimental therapeutic. The objective of the present study was to determine whether curcumin prevents cerebral ischemia/reperfusion injury by protecting blood-brain barrier integrity. We report that a single injection of curcumin (1 and 2 mg/kg, i.v.) 30 min after focal cerebral ischemia/reperfusion in rats significantly diminished infarct volume, improved neurological deficit, decreased mortality, reduced the water content of the brain and the extravasation of Evans blue dye in ipsilateral hemisphere in a dose-dependent manner. In cultured astrocytes, curcumin significantly inhibited inducible nitric oxide synthase (iNOS) expression and NO(x) (Nitrites/nitrates contents) production induced by lipopolysaccharide (LPS)/tumor necrosis factor alpha (TNF(alpha)). Furthermore, curcumin prevented ONOO(-) donor SIN-1-induced cerebral capillaries endothelial cells damage. We concluded that curcumin ameliorates cerebral ischemia/reperfusion injury by preventing ONOO(-) mediated blood-brain barrier damage.", "domain": "chemistry", "round": 3} +{"url": "https://cbdmagnates.com/2019/02/20/terpene-spotlight-linalool/", "date": "2020-12-04T21:06:03Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-50/segments/1606141743438.76/warc/CC-MAIN-20201204193220-20201204223220-00596.warc.gz", "language_score": 0.9391279220581055, "token_count": 882, "dump": "CC-MAIN-2020-50", "global_id": "webtext-fineweb__CC-MAIN-2020-50__0__180706289", "lang": "en", "text": "For centuries, humans have relied on the cannabis plant for its therapeutic properties. Much more than ever, cannabis can help in the remedy of chronic illness and as a supplement to their healthcare regime.\nAs the use of health-related marijuana increases in Florida, individuals are mastering that the Cannabis plant is a complicated and ancient organic remedy. Generally, individuals are prescribed opioids and other pharmaceutical drugs. Cannabis can alleviate the side-effects from these drugs. From PTSD to cancer to insomnia, health-related marijuana is an helpful technique of enhancing one’s mental and physical wellness and enhancing wellness-connected symptoms. There is archeological proof that proves that humans have utilised cannabis for at least 10,000 years recorded history, for at least five,000 years.\nThe endocannabinoid technique consists of cannabinoid receptors all more than the physique. This technique enables a connection amongst physique and thoughts, signaling to all other systems when one thing feels excellent or negative.\nTerpenes seem in abundance inside nature, and it is estimated that more than 20,000 terpenes exist inside our ecosystems. Each single plant, herb, flower, vegetable and fruit possess terpenes and every single terpene serves a extremely precise objective. Terpenes contribute to the characteristic odor and flavor of any plant.\nHundreds of distinct terpenes have been found inside the Cannabis plant, and they are frequently classified as principal and secondary terpenes, primarily based on how frequent they take place in cannabis. The odor represents a distinction amongst cannabis varieties which indicates that distinct plants can provide distinct advantages.\nThe terpenes, or terpenoids, type the biggest group of phytochemicals, and account for some medicinal properties of cannabis, as nicely as numerous medicinal herbs, plants and important oils. They are the supply of flavors, aromas, and other traits that aid differentiate cannabis strains. In addition, it is believed that the terpenes inside plants help in pest-manage and as an antifungal agent.\nCannabis and its Terpenes synchronize their chemical effects by operating concurrently. There are more than 100 confirmed Terpenes inside the plant globe, and every single plant assortment produces a one of a kind impact. Since of Terpenes, every single cannabis strain possesses a distinct taste and scent.\nTerpenes are aromatic molecules which are created inside the glands of cannabis flowers and buds. Some scents are deemed sweet and fruity although other Terpenes are woodsy, pungent, earthy or skunky. Though Terpenes give every single cannabis strain a one of a kind scent and flavor, these chemical compounds also contribute to the therapeutic effects that patient’s really feel.\nLinalool is 1 of the thousands of Terpenes that can be located in flowers and spices which includes citrus, lavender, rosewood, birch trees and coriander. This Terpene presents anti-inflammatory and analgesic activity, acts as an anti-nociception and anticonvulsant agent.\nLinalool also delivers anti-anxiousness/anxiety, sedation, and sleep-enhancement attributes. Substantially like the important oils located in the herb plant Lavender, Linalool is identified for curbing a patient’s anxiousness. The aroma and flavor of Linalool dominate cannabis delivers a calming impact for individuals. In addition, it has neighborhood anesthetic effects which mimicked the effects of the numbing agent procaine.\nIn 1 study, individuals who had been prescribed Morphine just after gastric banding surgery drastically decreased the quantity of the opioid just after inhaling lavender, a linalool terpene.\nSome of the cannabis strains in which hints of Linalool are noted:\nHealth-related marijuana can contribute to a patient’s all round wellness. Cannabis delivers important therapeutic advantages for a wide variety of health-related circumstances. Sufferers may perhaps want to experiment with a assortment of approaches offered for health-related marijuana consumption. Each and every patient should really seek the advice of their health-related marijuana doctor for a recommendation on the technique and strain to meet every single patient’s one of a kind wants.\nAnd do not be concerned, we hate spam as well! You can unsubscribe at anytime.", "domain": "chemistry", "round": 3} +{"url": "https://www.qmul.ac.uk/sbcs/iubmb/enzyme/EC6/2/1/37.html", "date": "2020-07-10T07:27:56Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-29/segments/1593655906214.53/warc/CC-MAIN-20200710050953-20200710080953-00223.warc.gz", "language_score": 0.7379066348075867, "token_count": 348, "dump": "CC-MAIN-2020-29", "global_id": "webtext-fineweb__CC-MAIN-2020-29__0__107161951", "lang": "en", "text": "Reaction: ATP + 3-hydroxybenzoate + CoA = AMP + diphosphate + 3-hydroxybenzoyl-CoA\nOther name(s): 3-hydroxybenzoyl-CoA synthetase; 3-hydroxybenzoatecoenzyme A ligase (AMP-forming); 3-hydroxybenzoyl coenzyme A synthetase; 3-hydroxybenzoyl-CoA ligase\nSystematic name: 3-hydroxybenzoate:CoA ligase (AMP-forming)\nComments: The enzyme works equally well with 4-hydroxybenzoate but shows low activity towards benzoate, 4-aminobenzoate, 3-aminobenzoate, 3-fluorobenzoate, 4-fluorobenzoate, 3-chlorobenzoate, and 4-chlorobenzoate. There is no activity with 3,4-dihydroxybenzoate, 2,3-dihydroxybenzoate, and 2-hydroxybenzoate as substrates.\nLinks to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:\n1. Laempe, D., Jahn, M., Breese, K., Schägger, H. and Fuchs, G. Anaerobic metabolism of 3-hydroxybenzoate by the denitrifying bacterium Thauera aromatica. J. Bacteriol. 183 (2001) 968-979. [PMID: 11208796]", "domain": "chemistry", "round": 3} +{"url": "https://microbiolj.org.ua/en/archiv/2022-tom-84/3-may-jun-tom-84/2022-84-3-01", "date": "2023-06-09T13:35:12Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-23/segments/1685224656737.96/warc/CC-MAIN-20230609132648-20230609162648-00509.warc.gz", "language_score": 0.8282111883163452, "token_count": 2002, "dump": "CC-MAIN-2023-23", "global_id": "webtext-fineweb__CC-MAIN-2023-23__0__246562337", "lang": "en", "text": "Mikrobiol. Z. 2022; 84(3):3-8.\nBacteria of the Black Sea Are Producers of Proteolytic Enzymes\nO.V. Gudzenko1, V.О. Ivanytsia2, L.D. Varbanets1\n1Zabolotny Institute of Microbiology and Virology, NAS of Ukraine\n154 Acad. Zabolotny Str., Kyiv, 03143, Ukraine\n2Mechnikov Odesa National University\n2 Dvoryanska Str., Odesa, 65029, Ukraine\nDespite the fact that in recent years there has been a certain enhancing interest in the study of marine microorganisms, nevertheless, marine bacteria as producers of biologically active substances, in particular enzymes, are still poorly studied. The marine biota is significantly different from the terrestrial one; therefore, there is a high probability of detecting in the marine environment different from terrestrial bacteria producers of enzymes with unique specificity and activity, for the needs of modern biotechnology. Proteolytic enzymes play an important role in these studies. Since the majority of microbial producers are characterized by a number of serious deficiencies, in particular, most of the elastase producers described in the literature are pathogenic for humans, the search for new, effective producers continues to be an urgent problem, given that highly active producers of proteolytic enzymes, in particular elastase, are generally absent in Ukraine. In this regard, the purpose of this work was to screen microorganisms isolated from the Black Sea for the presence of effective producers of proteolytic enzymes. Methods. We used methods of determining proteolytic (caseinilytic, elastolytic, fibrinolytic, fibrinogenolytic) activity. Results. The study of the enzymatic activity of the isolates showed that on the 10th day of cultivation in the supernatant of the culture liquid, caseinolytic activity was not detected only in one isolate 56, whereas very insignificant activity was observed in isolates 7, 20, and 50. The maximum activity was detected in isolate 247 (0.2 units/mL), and lower one - in isolates 46 (0.16 U/mL), 52 (0.15 U/mL), 51 (0.135 U/mL), 54 (0.08 U/mL), and 44 (0.05 U/mL). Of the 10 studied isolates, elastase activity was found only in four of them. The highest activity was found in isolates 51 and 54 (20.83 and 19.96 U/mL, respectively). Lower levels of activity (15.62 U/mL and 12.15 U/mL, respectively) were shown by isolates 52 and 247. The studied isolates also differed in their ability to hydrolyze fibrin and fibrinogen. T e highest fi brinolytic activity (2.33 U/mL) was found in isolates 46 and 54, significantly lower in isolate 20 (0.5 U/mL) and isolate 44 (0.33 U/mL). The rest isolates did not show fibrinolytic activity. As for fibrinogenolytic activity, it was noted in 6 studied cultures. The highest levels of activity were observed in isolate 51 (1.16 U/mL). Lower activity was found in isolates 54 (0.66 U/mL), 7 (0.5 U/mL), and 247 (0.33 U/mL). In isolate 50, it was minimal (0.083 U/mL). Conclusions. No correlation was found between elastase, fibrinolytic and fibrinogenic activity in the studied isolates. Thus, isolates 51, 54 and, to a lesser extent, 52 and 247 synthesize elastase activity. The highest fibrinolytic activity was in isolates 46 and 54, and fibrinogenolytic activity was in isolate 51. It was shown that the Black Sea is rich in marine bacterial species, which can be effective producers of a number of practically important enzymes, in particular, proteolytic ones with specificity to elastin, fibrin, and fibrinogen, which can be promising for implementation in biotechnological processes.\nKeywords: actinobacteria, the Black Sea, proteolytic activity.\n- Varbanets LD, Matseliukh EV. Peptidases of microorganisms and methods of their investigations. Kyiv, Naukova Dumka, 2014.\n- Matseliukh OV, Nidialkova NA, Varbanets LD. [Microbial elastolytic enzyme]. Biotechnology Z. 2010; 3(4):20—28. Ukrainian.\n- Farwa A, Shourong W, Vivi K. Role of fi brinolytic enzymes in anti-thrombosis therapy. Front Mol Biosci. 2021; 8:680397. https://doi.org/10.3389/fmolb.2021.680397\n- Silva GMM, Bezerra RP, Teixeira JA, Porto TS, Lima-Filho JL, Porto AF. Fibrinolytic protease production by new Streptomyces sp. DPUA 1576 from Amazon lichens. Electronic Journal of Biotechnology2015; 18(1):16—19. https://doi.org/10.1016/j.ejbt.2014.11.001\n- Yogesh D, Halami PM. Fibrinolytic enzymes of Bacillus spp.: an overview. International Food Research Journal. 2017; 24(1):35—47.\n- Chen B, Huo J, He Z, He Q, Hao Y, Che Z. Isolation and identification of an effective fibrinolytic strain Bacillus subtilis FR-33 from the Chinese doufuru and primary analysis of its fibrinolytic enzyme. Afr J Agric Res 2013; 7:2001—9. https://doi.org/10.5897/AJMR12.282\n- Hu Y, Yu D, Wang Z, Hou J, Tyagi R, Liang Y, Hu Y. Purification and characterization of a novel, highly potent fi brinolytic enzyme from Bacillus subtilis DC27 screened from Douchi, a traditional Chinese fermented soybean food. Sci Rep. 2019; 9(1):9235. https://doi.org/10.1038/s41598-019-45686-y\n- Frias J, Toubarro D, Fraga A, Botelho C, Teixeira J, Pedrosa J, Simoes N. Purification and characterization of a thrombolytic enzyme produced by a new strain of Bacillus subtilis. J Microbiol Biotechnol. 2021; 31(2):327—337. https://doi.org/10.4014/jmb.2008.08010\n- Dubey R, Kumar J, Agrawala D, Char T, Pusp P. Isolation, production, purification, assay and characterization of fibrinolytic enzymes (Nattokinase, Streptokinase and Urokinase) from bacterial sources. Afr J Biotechnol. 2011; 10 (8):1408—1420.\n- Petrova IS, Vintsyunayte MN. [Determination proteolytic activity enzyme preparations of microbial origin]. Prikl Biokhim Mikrobiol. 1966; 2(1):322—327. Russian.\n- Trombridg GO, Moon HD. Purification of human elastase. Proc Soc Exp Biol Med. 1972; 141(3):928—931. https://doi.org/10.3181/00379727-141-36903\n- Nidialkova NA, Matseliukh OV, Varbanets LD. [Physico-chemical properties of Bacillus thuringiensis IMV B-7324 fibrinolytic peptidase]. Mikrobiol Z. 2013; 75(4):3—7. Ukrainian.\n- Borzova N.V., Gudzenko O.V., Avdiyuk K.V., Varbanets L.D., Nakonechna L.T. Thermophilic Fungi with Glucosidase and Proteolytic Activities. Mikrobiol. Z. 2021; 83(3):24—34. https://doi.org/10.15407/microbiolj83.03.024\n- Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with folinphenol reagent. J Biol Chem. 1951; 193(2):265—275. https://doi.org/10.1016/S0021-9258(19)52451-6\n- Lakyn HF. [Byometryia]. Moscow: Vysshaya Shkola; 1990. Russian.\n- Varbanets LD, Avdeeva LV, Borzova NV, Matseliukh EV, Gudzenko AV, Kiprianova EA. [Th e Black Sea bacteriaproducers of hydrolytic enzymes]. Mikrobiol Z. 2011; 73(5):9—15. Ukrainian.", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/ptp1b-antibody-ab226878.html", "date": "2020-10-22T20:36:57Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-45/segments/1603107880038.27/warc/CC-MAIN-20201022195658-20201022225658-00273.warc.gz", "language_score": 0.7540653944015503, "token_count": 619, "dump": "CC-MAIN-2020-45", "global_id": "webtext-fineweb__CC-MAIN-2020-45__0__205397743", "lang": "en", "text": "Key features and details\n- Rabbit polyclonal to PTP1B\n- Suitable for: IHC-P, WB\n- Reacts with: Human\n- Isotype: IgG\nProduct nameAnti-PTP1B antibody\nSee all PTP1B primary antibodies\nDescriptionRabbit polyclonal to PTP1B\nTested applicationsSuitable for: IHC-P, WBmore details\nSpecies reactivityReacts with: Human\nPredicted to work with: Mouse, Rat, Chicken, Cow, Pig, Rhesus monkey\nRecombinant fragment within Human PTP1B (internal sequence). The exact sequence is proprietary.\nDatabase link: P18031\n- IHC-P: Human colon carcinoma tissue. WB: Raji whole cell lysate.\nStorage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.\nStorage bufferpH: 7.00\nPreservative: 0.01% Thimerosal (merthiolate)\nConstituents: 1.21% Tris, 0.75% Glycine, 10% Glycerol (glycerin, glycerine)\nConcentration information loading...\nPurityImmunogen affinity purified\nOur Abpromise guarantee covers the use of ab226878 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\n|IHC-P||1/100 - 1/1000.|\n|WB||1/500 - 1/3000. Predicted molecular weight: 50 kDa.|\nFunctionMay play an important role in CKII- and p60c-src-induced signal transduction cascades.\nSequence similaritiesBelongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily.\nContains 1 tyrosine-protein phosphatase domain.\nmodificationsOxidized on Cys-215; the Cys-SOH formed in response to redox signaling reacts with the alpha-amido of the following residue to form a 4-amino-3-isothiazolidinone serine cross-link, triggering a conformational change that inhibits substrate binding and activity. The active site can be restored by reduction.\nCellular localizationEndoplasmic reticulum membrane.\n- Information by UniProt\n- PTP1B antibody\n- Non receptor tyrosine phosphatase 1 antibody\n- Protein phosphotyrosylphosphatase 1B antibody\nTo our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.\nab226878 has not yet been referenced specifically in any publications.", "domain": "chemistry", "round": 3} +{"url": "http://www.sbir.gov/sbirsearch/detail/14443", "date": "2014-11-26T19:11:17Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2014-49/segments/1416931007324.75/warc/CC-MAIN-20141125155647-00078-ip-10-235-23-156.ec2.internal.warc.gz", "language_score": 0.8959571123123169, "token_count": 368, "dump": "CC-MAIN-2014-49", "global_id": "webtext-fineweb__CC-MAIN-2014-49__0__89621718", "lang": "en", "text": "Composite CFRP Drilling Enviromentally Friendly Coolant System\nThis Small Business Innovation Research (SBIR) Phase I project aims to develop a novel environmentally-friendly CO2 coolant system to drill CFRP-Ti (Carbon Fiber Reinforced Plastic with layers of Titanium) used in the aerospace industry. Carbon dioxide will be applied as frozen dry-ice (CO2) particles through the drill stem directly into the drill cut zone, providing significant controllable cooling and lubrication to the drill and the surrounding CFRP-Ti material. A bio-based lubricant may be added to provide additional lubrication if necessary.\nThe broader/commercial impact of this project will be the potential to provide an environmentally-benign coolant system for CFRP-Ti drilling applications. The aerospace industry is using more CFRP-Ti in aircraft components as it is more durable and lighter than aluminum or similar metals. However, CFRP-Ti is abrasive and difficult to drill, resulting in significant heat being generated from the force and the friction of drilling, which is detrimental to the CFRP base materials. The industry currently uses petroleum oil and water for cooling, which has following problems, (1) it does not provide adequate cooling; (2) it is not environmentally friendly and must be treated as hazardous waste; (3) it requires biocides to reduce bacteria; and (4) it is not conducive to a healthy and safe worker environment. This project may provide a novel coolant system with environmental benefits, improved quality, and reduced cost structure. Furthermore, the CO2 used in this process will be recycled from other industrial sources, thereby not a CO2 generator.\nSmall Business Information at Submission:\n915 Blue Gentian Rd Suite 11 Saint Paul, MN 55121\nNumber of Employees:", "domain": "chemistry", "round": 3} +{"url": "https://labnodes.vanderbilt.edu/publication/view/pmid/25898914", "date": "2021-05-16T12:25:29Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-21/segments/1620243991269.57/warc/CC-MAIN-20210516105746-20210516135746-00424.warc.gz", "language_score": 0.9179913997650146, "token_count": 277, "dump": "CC-MAIN-2021-21", "global_id": "webtext-fineweb__CC-MAIN-2021-21__0__205968784", "lang": "en", "text": "Manganese (Mn) is a required cofactor for all forms of life. Given the importance of Mn to bacteria, the host has devised strategies to sequester Mn from invaders. In the macrophage phagosome, NRAMP1 removes Mn and other essential metals to starve intracellular pathogens; in the extracellular space, calprotectin chelates Mn and Zn. Calprotectin-mediated Mn sequestration is a newly appreciated host defense mechanism, and recent findings are highlighted herein. In order to acquire Mn when extracellular concentrations are low, bacteria have evolved efficient Mn acquisition systems that are under elegant transcriptional control. To counteract Mn overload, some bacteria possess Mn-specific export systems that are important in vivo, presumably for control of intracellular Mn levels. Mn transporters, their transcriptional regulators and some Mn-requiring enzymes are necessary for virulence of certain bacterial pathogens, as revealed by animal models of infection. Furthermore, Mn is an important facet of the cellular response to oxidative stress, a host antibacterial strategy. The battle for Mn between host and pathogen is now appreciated to be a major determinant of the outcome of infection. In this MicroReview, the contribution of Mn to the host-pathogen interaction is reviewed, and key questions are proposed for future study.\n© 2015 John Wiley & Sons Ltd.", "domain": "chemistry", "round": 3} +{"url": "https://www.hindawi.com/journals/jnm/2013/832710/ref/", "date": "2017-02-23T21:02:56Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-09/segments/1487501171232.43/warc/CC-MAIN-20170219104611-00283-ip-10-171-10-108.ec2.internal.warc.gz", "language_score": 0.7338201999664307, "token_count": 3695, "dump": "CC-MAIN-2017-09", "global_id": "webtext-fineweb__CC-MAIN-2017-09__0__129702388", "lang": "en", "text": "- About this Journal ·\n- Abstracting and Indexing ·\n- Aims and Scope ·\n- Annual Issues ·\n- Article Processing Charges ·\n- Articles in Press ·\n- Author Guidelines ·\n- Bibliographic Information ·\n- Citations to this Journal ·\n- Contact Information ·\n- Editorial Board ·\n- Editorial Workflow ·\n- Free eTOC Alerts ·\n- Publication Ethics ·\n- Reviewers Acknowledgment ·\n- Submit a Manuscript ·\n- Subscription Information ·\n- Table of Contents\nJournal of Nanomaterials\nVolume 2013 (2013), Article ID 832710, 9 pages\nPreparation and Characterization of a Novel Hybrid Hydrogel Composed of Bombyx mori Fibroin and Poly(N-isopropylacrylamide)\nInstitute of Ecology and Environment, State Key Laboratory of Hydraulics and Mountain River Engineering, Sichuan University, Chengdu 610065, China\nReceived 18 September 2012; Accepted 22 November 2012\nAcademic Editor: Lian Gao\nCopyright © 2013 Ting Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.\n- C. Vepari and D. L. Kaplan, “Silk as a biomaterial,” Progress in Polymer Science, vol. 32, no. 8-9, pp. 991–1007, 2007.\n- C. Z. Zhou, F. Confalonieri, N. Medina et al., “Fine organization of Bombyx mori fibroin heavy chain gene,” Nucleic Acids Research, vol. 28, no. 12, pp. 2413–2419, 2000.\n- D. P. Tieleman, I. H. Shrivastava, M. R. Ulmschneider, and M. S. P. Sansom, “Silk fibroin: structural implications of a remarkable amino acid sequence,” Proteins, vol. 44, no. 2, pp. 119–122, 2001.\n- S. Ghosh, S. T. Parker, X. Wang, D. L. Kaplan, and J. A. Lewis, “Direct-write assembly of microperiodic silk fibroin scaffolds for tissue engineering applications,” Advanced Functional Materials, vol. 18, no. 13, pp. 1883–1889, 2008.\n- R. Nazarov, H. J. Jin, and D. L. Kaplan, “Porous 3-D scaffolds from regenerated silk fibroin,” Biomacromolecules, vol. 5, no. 3, pp. 718–726, 2004.\n- C. Li, H. J. Jin, G. D. Botsaris, and D. L. Kaplan, “Silk apatite composites from electrospun fibers,” Journal of Materials Research, vol. 20, no. 12, pp. 3374–3384, 2005.\n- B. M. Min, G. Lee, S. H. Kim, Y. S. Nam, T. S. Lee, and W. H. Park, “Electrospinning of silk fibroin nanofibers and its effect on the adhesion and spreading of normal human keratinocytes and fibroblasts in vitro,” Biomaterials, vol. 25, no. 7-8, pp. 1289–1297, 2004.\n- U. J. Kim, J. Park, C. Li, H. J. Jin, R. Valluzzi, and D. L. Kaplan, “Structure and properties of silk hydrogels,” Biomacromolecules, vol. 5, no. 3, pp. 786–792, 2004.\n- J. Y. Fang, J. P. Chen, Y. L. Leu, and H. Y. Wang, “Characterization and evaluation of silk protein hydrogels for drug delivery,” Chemical and Pharmaceutical Bulletin, vol. 54, no. 2, pp. 156–162, 2006.\n- A. Matsumoto, J. Chen, A. L. Collette et al., “Mechanisms of silk fibroin sol-gel transitions,” Journal of Physical Chemistry B, vol. 110, no. 43, pp. 21630–21638, 2006.\n- M. Djabourov, J. P. Lechaire, and F. Gaill, “Structure and rheology of gelatin and collagen gels,” Biorheology, vol. 30, no. 3-4, pp. 191–205, 1993.\n- S. Zhang, “Fabrication of novel biomaterials through molecular self-assembly,” Nature Biotechnology, vol. 21, no. 10, pp. 1171–1178, 2003.\n- Z. H. Ayub, M. Arai, and K. Hirabayashi, “Quantitative structural analysis and physical properties of silk fibroin hydrogels,” Polymer, vol. 35, no. 10, pp. 2197–2200, 1994.\n- M. Li, W. Tao, S. Kuga, and Y. Nishiyama, “Controlling molecular conformation of regenerated wild silk fibroin by aqueous ethanol treatment,” Polymers for Advanced Technologies, vol. 14, no. 10, pp. 694–698, 2003.\n- H. J. Jin, J. Park, R. Valluzzi, P. Cebe, and D. L. Kaplan, “Biomaterial films of Bombyx mori silk fibroin with poly(ethylene oxide),” Biomacromolecules, vol. 5, no. 3, pp. 711–717, 2004.\n- G. D. Kang, J. H. Nahm, J. S. Park, J. Y. Moon, C. S. Cho, and J. H. Yeo, “Effects of poloxamer on the gelation of silk fibroin,” Macromolecular Rapid Communications, vol. 21, no. 11, pp. 788–791, 2000.\n- X. Wang, J. A. Kluge, G. G. Leisk, and D. L. Kaplan, “Sonication-induced gelation of silk fibroin for cell encapsulation,” Biomaterials, vol. 29, no. 8, pp. 1054–1064, 2008.\n- Q. Lv, K. Hu, Q. Feng, and F. Cui, “Fibroin/collagen hybrid hydrogels with crosslinking method: preparation, properties, and cytocompatibility,” Journal of Biomedical Materials Research A, vol. 84, no. 1, pp. 198–207, 2008.\n- X. Chen, W. Li, W. Zhong, Y. Lu, and T. Yu, “pH sensitivity and ion sensitivity of hydrogels based on complex-forming chitosan/silk fibroin interpenetrating polymer network,” Journal of Applied Polymer Science, vol. 65, no. 11, pp. 2257–2262, 1997.\n- H. Y. Kweon, S. H. Park, and J. H. Yeo, “Preparation of semi-interpenetrating polymer networks composed of silk fibroin and poly(ethylene glycol) macromer,” Journal of Applied Polymer Science, vol. 80, no. 10, pp. 1848–1853, 2001.\n- M. K. Yoo, H. Y. Kweon, K. G. Lee, H. C. Lee, and C. S. Cho, “Preparation of semi-interpenetrating polymer networks composed of silk fibroin and poloxamer macromer,” International Journal of Biological Macromolecules, vol. 34, no. 4, pp. 263–270, 2004.\n- E. S. Gil and S. M. Hudson, “Effect of silk fibroin interpenetrating networks on swelling/deswelling kinetics and rheological properties of poly(N-isopropylacrylamide) hydrogels,” Biomacromolecules, vol. 8, no. 1, pp. 258–264, 2007.\n- M. Li, S. Lu, Z. Wu, K. Tan, N. Minoura, and S. Kuga, “Structure and properties of silk fibroin-poly(vinyl alcohol) gel,” International Journal of Biological Macromolecules, vol. 30, no. 2, pp. 89–94, 2002.\n- Q. Lv, Q. Feng, K. Hu, and F. Cui, “Three-dimensional fibroin/collagen scaffolds derived from aqueous solution and the use for HepG2 culture,” Polymer, vol. 46, no. 26, pp. 12662–12669, 2005.\n- E. S. Gil, D. J. Frankowski, R. J. Spontak, and S. M. Hudson, “Swelling behavior and morphological evolution of mixed gelatin/silk fibroin hydrogels,” Biomacromolecules, vol. 6, no. 6, pp. 3079–3087, 2005.\n- B. Jeong, S. W. Kim, and Y. H. Bae, “Thermosensitive sol-gel reversible hydrogels,” Advanced Drug Delivery Reviews, vol. 54, no. 1, pp. 37–51, 2002.\n- W. E. Rudzinski, A. M. Dave, U. H. Vaishnav, S. G. Kumbar, A. R. Kulkarni, and T. M. Aminabhavi, “Hydrogels as controlled release devices in agriculture,” Designed Monomers and Polymers, vol. 5, no. 1, pp. 39–65, 2002.\n- R. C. Mundargi, N. B. Shelke, V. R. Babu, P. Patel, V. Rangaswamy, and T. M. Aminabhavi, “Novel thermo-responsive semi-interpenetrating network microspheres of gellan gum-poly(N-isopropylacrylamide) for controlled release of atenolol,” Journal of Applied Polymer Science, vol. 116, no. 3, pp. 1832–1841, 2010.\n- K. M. Reddy, V. R. Babu, K. S. V. K. Rao et al., “Temperature sensitive semi-IPN microspheres from sodium alginate and N-isopropylacrylamide for controlled release of 5-fluorouracil,” Journal of Applied Polymer Science, vol. 107, no. 5, pp. 2820–2829, 2008.\n- K. S. Soppimath, T. M. Aminabhavi, A. M. Dave, S. G. Kumbar, and W. E. Rudzinski, “Stimulus-responsive “smart” hydrogels as novel drug delivery systems,” Drug Development and Industrial Pharmacy, vol. 28, no. 8, pp. 957–974, 2002.\n- N. B. Shelke, S. V. Kumar, K. M. Mahadevan, B. S. Sherigara, and T. M. Aminabhavi, “Synthesis, characterization, and evaluation of copolymers based on N-isopropylacrylamide and 2-ethoxyethyl methacrylate for the controlled release of felodipine,” Journal of Applied Polymer Science, vol. 110, no. 4, pp. 2211–2217, 2008.\n- X. Z. Zhang, Y. Y. Yang, T. S. Chung, and K. X. Ma, “Preparation and characterization of fast response macroporous poly(N-isopropylacrylamide) hydrogels,” Langmuir, vol. 17, no. 20, pp. 6094–6099, 2001.\n- Y. Miyahara, N. Nagaya, M. Kataoka et al., “Monolayered mesenchymal stem cells repair scarred myocardium after myocardial infarction,” Nature Medicine, vol. 12, no. 4, pp. 459–465, 2006.\n- S. H. Choi, J. J. Yoon, and T. G. Park, “Galactosylated poly(N-isopropylacrylamide) hydrogel submicrometer particles for specific cellular uptake within hepatocytes,” Journal of Colloid and Interface Science, vol. 251, no. 1, pp. 57–63, 2002.\n- X. D. Xu, H. Wei, X. Z. Zhang, S. X. Cheng, and R. X. Zhuo, “Fabrication and characterization of a novel composite PNIPAAm hydrogel for controlled drug release,” Journal of Biomedical Materials Research A, vol. 81, no. 2, pp. 418–426, 2007.\n- C. Chang, H. Wei, C. Y. Quan et al., “Fabrication of thermosensitive PCL-PNIPAAm-PCL triblock copolymeric micelles for drug delivery,” Journal of Polymer Science A, vol. 46, no. 9, pp. 3048–3057, 2008.\n- W. Liu, B. Zhang, W. W. Lu et al., “A rapid temperature-responsive sol-gel reversible poly(N-isopropylacrylamide)-g-methylcellulose copolymer hydrogel,” Biomaterials, vol. 25, no. 15, pp. 3005–3012, 2004.\n- M. W. Tibbitt and K. S. Anseth, “Hydrogels as extracellular matrix mimics for 3D cell culture,” Biotechnology and Bioengineering, vol. 103, no. 4, pp. 655–663, 2009.\n- H. Cheng, L. Shen, and C. Wu, “LLS and FTIR studies on the hysteresis in association and dissociation of poly(N-isopropylacrylamide) chains in water,” Macromolecules, vol. 39, no. 6, pp. 2325–2329, 2006.\n- A. Martínez-Ruvalcaba, E. Chornet, and D. Rodrigue, “Viscoelastic properties of dispersed chitosan/xanthan hydrogels,” Carbohydrate Polymers, vol. 67, no. 4, pp. 586–595, 2007.\n- H. H. Winter and F. Chambon, “Analysis of linear viscoelasticity of a crosslinking polymer at the gel point,” Journal of Rheology, vol. 30, no. 2, pp. 367–382, 1986.\n- E. E. Holly, S. K. Venkataraman, F. Chambon, and H. H. Winter, “Fourier transform mechanical spectroscopy of viscoelastic materials with transient structure,” Journal of Non-Newtonian Fluid Mechanics, vol. 27, no. 1, pp. 17–26, 1988.\n- S. Y. Kim, D. G. Choi, and S. M. Yang, “Rheological analysis of the gelation behavior of tetraethylorthosilane/vinyltriethoxysilane hybrid solutions,” Korean Journal of Chemical Engineering, vol. 19, no. 1, pp. 190–196, 2002.\n- B. Ranjbar and P. Gill, “Circular dichroism techniques: biomolecular and nanostructural analyses—a review,” Chemical Biology and Drug Design, vol. 74, no. 2, pp. 101–120, 2009.\n- Y. Pei, J. Chen, L. Yang et al., “The effect of pH on the LCST of poly(N-isopropylacrylamide) and poly(N-isopropylacrylamide-co-acrylic acid),” Journal of Biomaterials Science, vol. 15, no. 5, pp. 585–594, 2004.", "domain": "chemistry", "round": 3} +{"url": "http://scitation.aip.org/content/aip/proceeding/aipcp/10.1063/1.1812054", "date": "2013-12-06T23:18:11Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2013-48/segments/1386163052727/warc/CC-MAIN-20131204131732-00040-ip-10-33-133-15.ec2.internal.warc.gz", "language_score": 0.7071441411972046, "token_count": 426, "dump": "CC-MAIN-2013-48", "global_id": "webtext-fineweb__CC-MAIN-2013-48__0__29712037", "lang": "en", "text": "Luminescence from pillar suspended single‐walled carbon nanotubes\n- Conference date: 6-13 March 2004\n- Location: Kirchberg, Tirol (Austria)\nThis paper reviews our recent effort in the study of photoluminescence (PL) from single‐walled carbon nanotubes (SWNTs) suspended between pillars. Luminescence is obtained from both ensembles and individual SWNTs in air, at room temperature without any post‐growth processing. PL spectra reveal some of the one‐dimensional characteristics expected for this material system, such as narrow asymmetric linewidths, and polarized emission and absorption.\n- Carbon nanotubes\n- Materials properties\n- Absorption spectra\n- Emission spectra\n- Spectral properties\nMOST READ THIS MONTH\nMOST CITED THIS MONTH\nY. K. Semertzidis, M. Aoki, M. Auzinsh, V. Balakin, A. Bazhan, G. W. Bennett, R. M. Carey, P. Cushman, P. T. Debevec, A. Dudnikov, F. J. M. Farley, D. W. Hertzog, M. Iwasaki, K. Jungmann, D. Kawall, B. Khazin, I. B. Khriplovich, B. Kirk, Y. Kuno, D. M. Lazarus, L. B. Leipuner, V. Logashenko, K. R. Lynch, W. J. Marciano, R. McNabb, W. Meng, J. P. Miller, W. M. Morse, C. J. G. Onderwater, Y. F. Orlov, C. S. Ozben, R. Prigl, S. Rescia, B. L. Roberts, N. Shafer‐Ray, A. Silenko, E. J. Stephenson, K. Yoshimura and EDM Collaboration\nArticle metrics loading...", "domain": "chemistry", "round": 3} +{"url": "https://www.creative-diagnostics.com/Anti-Rotavirus-Antibody-52825-144.htm", "date": "2018-09-19T01:38:42Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-39/segments/1537267155814.1/warc/CC-MAIN-20180919004724-20180919024724-00282.warc.gz", "language_score": 0.7252116203308105, "token_count": 253, "dump": "CC-MAIN-2018-39", "global_id": "webtext-fineweb__CC-MAIN-2018-39__0__227006330", "lang": "en", "text": "Mouse Anti-Rotavirus Monoclonal antibody for ELISA, WB, IH\nBohacova, V; Sulova, Z; et al. L1210 cells cultivated under the selection pressure of doxorubicin or vincristine express common mechanisms of multidrug resistance based on the overexpression of P-glycoprotein. TOXICOLOGY IN VITRO 20:1560-1568(2006).\nBecker-Dreps, S; Vilchez, S; et al. Rotavirus-specific IgG Antibodies From Mothers' Serum May Inhibit Infant Immune Responses to the Pentavalent Rotavirus Vaccine. PEDIATRIC INFECTIOUS DISEASE JOURNAL 34:115-116(2015).\nCustom Antibody Labeling\nWe offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody.", "domain": "chemistry", "round": 3} +{"url": "https://www.nsenergybusiness.com/news/siemens-co2-free-hydrogen-production-germany/", "date": "2022-05-25T01:25:51Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-21/segments/1652662577757.82/warc/CC-MAIN-20220524233716-20220525023716-00456.warc.gz", "language_score": 0.9108495116233826, "token_count": 478, "dump": "CC-MAIN-2022-21", "global_id": "webtext-fineweb__CC-MAIN-2022-21__0__303949328", "lang": "en", "text": "The new carbon-free hydrogen production plant will have an annual production capacity of 2,000 tonnes\nSiemens Smart Infrastructure and hydrogen specialist WUN H2 are planning to build what it claims to be one of the largest hydrogen (H2) production plants in Germany.\nLocated in Wunsiedel in the north of Bavaria, the new CO2-free hydrogen production plant will have a production capacity of 2,000 tonnes annually.\nThe project’s first-phase involves power intake of 6MW of renewable capacity and produce 900 tonnes of hydrogen, once commissioned scheduled in 2021.\nConstruction on the first phase of the project is slated to commence by the end of 2020.\nThe proposed hydrogen production plant is expected to contribute to Germany’s aim to be greenhouse gas-neutral by 2050.\nSWW Wunsiedel CEO Marco Krasser said: “For the first time, the oxygen and the low-temperature waste heat generated during production are planned to be reused by nearby industrial operations.\n“This will result in maximum energy efficiency and a plant that is unique because all element flows will be utilized. In addition, electrolysis is an important building block toward implementing the ‘WUNsiedeler Weg – energy’, where we make sustainably energy use and climate protection a reality.”\nProposed plant will convert renewable energy into storable hydrogen\nThe project will be able to convert renewable energy into storable hydrogen while making it available for applications in mobility and industry. It will serve as an exclusive hydrogen source for northern Bavaria and the border region in Czech Republic, Siemens said.\nThe electrolysis plant is planned to be built in the Wunsiedel Energy Park, next to the Siemens’ operational manufactured battery storage facility, to complement the future energy concept.\nSmart Infrastructure Regional Solutions & Services Germany CEO and Siemens Germany CEO Uwe Bartmann said: “This project is another element of a practised, successful technology partnership between Siemens and SWW Wunsiedel GmbH. We want to achieve locally already today what Germany is targeting for 2050, namely a complete energy transition across all sectors.”\nRecently, Siemens Energy was selected to supply hydrogen production system for a hydrogen fuelling station in Yanqing District, Beijing, China.", "domain": "chemistry", "round": 3} +{"url": "https://www.hindawi.com/journals/er/2012/845465/", "date": "2023-02-04T03:27:34Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-06/segments/1674764500080.82/warc/CC-MAIN-20230204012622-20230204042622-00619.warc.gz", "language_score": 0.8739501237869263, "token_count": 5172, "dump": "CC-MAIN-2023-06", "global_id": "webtext-fineweb__CC-MAIN-2023-06__0__246096152", "lang": "en", "text": "In Silico Characterization of Histidine Acid Phytase Sequences\nHistidine acid phytases (HAPhy) are widely distributed enzymes among bacteria, fungi, plants, and some animal tissues. They have a significant role as an animal feed enzyme and in the solubilization of insoluble phosphates and minerals present in the form of phytic acid complex. A set of 50 reference protein sequences representing HAPhy were retrieved from NCBI protein database and characterized for various biochemical properties, multiple sequence alignment (MSA), homology search, phylogenetic analysis, motifs, and superfamily search. MSA using MEGA5 revealed the presence of conserved sequences at N-terminal “RHGXRXP” and C-terminal “HD.” Phylogenetic tree analysis indicates the presence of three clusters representing different HAPhy, that is, PhyA, PhyB, and AppA. Analysis of 10 commonly distributed motifs in the sequences indicates the presence of signature sequence for each class. Motif 1 “SPFCDLFTHEEWIQYDYLQSLGKYYGYGAGNPLGPAQGIGF” was present in 38 protein sequences representing clusters 1 (PhyA) and 2 (PhyB). Cluster 3 (AppA) contains motif 9 “KKGCPQSGQVAIIADVDERTRKTGEAFAAGLAPDCAITVHTQADTSSPDP” as a signature sequence. All sequences belong to histidine acid phosphatase family as resulted from superfamily search. No conserved sequence representing 3- or 6-phytase could be identified using multiple sequence alignment. This in silico analysis might contribute in the classification and future genetic engineering of this most diverse class of phytase.\nPhytate (myo-inositol 1,2,3,4,5,6-hexakisphosphate; IP6) is the major storage form of phosphorus (P), representing approximately 80% of P in soil , 65–80% of total P in grains , and up to 80% of P in manures from monogastric animals . Phytate exists primarily as metal phytate complex with nutritionally important cations, that is, Ca2+, Fe2+, and Zn2+ .\nPhytases (IP6 phosphohydrolase) are a class of phosphatases which catalyses hydrolysis of phytate to inositol phosphates, inorganic phosphorus, and myo-inositol , also lowers down affinity of phytate to associated minerals and proteins , and thus increases bioavailability of P, minerals, and proteins for growth and development of plants and animals [7–9].\nPhytases are widely distributed among plants [10, 11], certain animal tissues, and microbial cells [12–15]. To date, four classes of phytases have been characterized in terrestrial organisms: histidine acid phytase (HAPhy), cysteine phytase (CPhy), purple acid phosphatase (PAP), and -propeller phytase (BPPhy) [16, 17]. HAPhys are the most studied and diverse class of phytase. Most bacterial, fungal, and plant phytases belong to histidine acid phosphatases (EC 18.104.22.168) which are further classified as 3-phytase (EC 22.214.171.124) or 6-phytase (EC 126.96.36.199) due to their high specific activity for phytate and position specific initial hydrolysis of phytate.\nPhytases have been extensively reviewed for various industrial and biotechnological applications [18–21], biochemical properties , and consensus phytase construct . Conserved amino acid residues are reported in HAPhy sequences at N-terminal “RHGXRXP,” C-terminal “HD,” and eight cysteine residues in around sequence [16, 24, 25]. It is a well-adopted fact that all phytases have not similar and common active site; hence the initial classification system is based on catalytic mechanism . Still, there is a need to devise a taxonomic system to accommodate new types of phytases with novel catalytic mechanism.\nThe in silico characterization of protein sequences of industrially important enzymes has been reported recently [26–28]. Biochemical features, homology search, multiple sequence alignment, phylogenetic tree construction, motif, and superfamily distribution of alkaline proteases have been analyzed using various bioinformatics tools . A total of 121 protein sequences of pectate lyases were subjected to homology search, multiple sequence alignment, phylogenetic tree construction, and motif analysis . Malviya et al. collected forty-seven full-length amino acid sequences of PPO from bacteria, fungi, and plants and subjected them to multiple sequence alignment (MSA), domain identification, and phylogenetic tree construction.\nIn the present study, we performed in silico analysis of 50 HAPhy protein sequences. The biochemical features, homology search, multiple sequence alignment, phylogenetic tree construction, motif, and superfamily distribution have been analyzed using various bioinformatics tools.\n2. Material and Methods\nRepresentative genes from histidine acid phytases (E. coli AppA, GenBank accession number P07102; Aspergillus niger PhyA and PhyB, P34752 and P34754) were used as probes to BLAST microbial genome database from NCBI (http://www.ncbi.nlm.nih.gov/). The protein sequences in FASTA format from RefSeq entries, which were shown to exhibit phytase activities, were selected for further in silico study.\nPhysiochemical data were generated from various tools in the EXPASY proteomic server (ClustalW, ProtParam, protein calculator, Compute pI/Mw, ProtScale) . The molecular weights (kDa) of the various histidine acid phytases were calculated by the addition of average isotopic masses of amino acid in the protein and deducting the average isotopic mass of one water molecule. The pI of enzyme was calculated using pK values of amino acid according to Bjellqvist et al. .\nThe evolutionary history was inferred using the Neighbor-Joining method . The tree is drawn to scale, with branch lengths in the same units as those of the evolutionary distances used to infer the phylogenetic tree. The evolutionary distances were computed using the Poisson correction method and are in the units of the number of amino acid substitutions per site. All positions containing gaps and missing data were eliminated. There were a total of 303 positions in the final dataset. Evolutionary analyses were conducted in MEGA5 . For domain search, the Pfam site (http://www.sanger.ac.uk/resources/software/) was used. Domain analysis was done using MEME (http://meme.nbcr.net/meme/) . The conserved protein motifs deduced by MEME were characterized for biological function analysis using protein BLAST, and domains were studied with InterProScan providing the best possible match based on the highest similarity score.\n3. Result and Discussion\nThe 50 protein sequences of HAPhy were retrieved from NCBI. The accession number of retrieved sequences along with species names is listed in Table 1. The sequences were characterized for homology search, multiple sequences alignment, biochemical features, phylogenetic tree construction, motifs, and superfamily search using various bioinformatics tools. Out of 50 sequences 12 sequences belong to HAPhy gene AppA, 26 sequences to PhyA, and 12 sequences to PhyB.\nMultiple sequence alignment showed presence of conserved sites for HAPhy N-terminal “RHG/NXRXP” and C-terminal “HD” in all sequences as reported by other coworkers . This is consistent with Pfam analysis of predicted active site residues, which in all sequences is shown to be N-terminal histidine residue present in conserved region and C-terminal aspartic acid. The histidine in N-terminal region seems as a nucleophile in the formation of a covalent phosphohistidine intermediate . Aspartic acid at C-terminal “HD” sequence acts as a proton donor to the oxygen atom of the scissile phosphomonoester bond [36, 37]. No conserved sequence representing 3- or 6-phytase could be identified using multiple-sequence alignment.\nThe phylogenetic tree based on protein sequences revealed three major clusters. Cluster 1, a larger cluster containing 26 sequences under study, includes the majority of Aspergillus sp., Penicillium sp., Ajellomyces sp., Arthroderma sp., Trichophyton sp., Sclerotinia sp., Uncinocarpus sp., and Coccidioides sp. (Figure 1). Biochemical features for this cluster are listed in Table 2. The total number of amino acid residues ranged from 441 to 539 with variable molecular weights. pI values of this cluster ranged from 4.87 to 8.53. Variations among various phytase in this group in terms of other physiochemical parameters like positively charged and negatively charged residues, hydropathicity (GRAVY) are given in Table 2.\nAliphatic index analysis reveals uniformity in this group of phytases within the range of except for some sequences of Arthroderma sp. (XP_002849736.1, XP_003169494.1, XP_003015622.1) and Trichophyton sp. (XP_003021635.1). Aliphatic index of protein measures the relative volume occupied by aliphatic side chains of the amino acids: alanine, valine, leucine, and isoleucine. Globular proteins with high aliphatic index have high thermostability, and an increase in aliphatic index increases protein thermostability [38, 39].\nCluster 2 includes 12 protein sequences and represents PhyB gene sequences including the majority of Candida sp., S. cerevisiae, C. posadasii, and D. hansenii. Total number of sequences in this group is in the range of 457 to 479, and the pI values range from 4.41 to 5.82. It has less variation in its pI as compared to cluster 1 sequences (PhyA). Aliphatic index of this cluster sequences is uniform in the range of except for Candida tropicalis (XP_002546108.1) with a value of 67.74 and Komagataella pastoris (XP_002490985.1) with a value of 84.19.\nCluster 3 represents protein sequences from phytase gene AppA, also abbreviated as PhyC , which includes E. coli (in majority) along with various Shigella sp. and Citrobacter freundii. Various biophysical parameters for this group of sequences reveal amino acid residues ranging from 428 to 523, while pI value of the majority of sequences is in range of 5.5 to 6.5 except for E. albertii (9.35) and E. fergusonii (8.37). Aliphatic index of this group of sequences reveals highest thermostability among all three clusters. Predominantly positively charged amino acids are present in all three clusters.\nThe instability index is used to measure in vivo half-life of a protein . The proteins which have been reported as in vivo half-life of less than 5 hours showed instability index greater than 40, whereas those having more than 16 hours half-life have an instability index of less than 40. Instability index of HAP sequences under the study is found higher than 40 (Table 2) for 15 sequences including fully characterized E. coli and A. niger phytases, indicating an in vivo half-life of less than 5 hours. Superfam tool on ExPASy server for superfamily analysis of phytase sequences reveals the identity of all sequences to histidine acid phosphatase family belonging to phosphoglycerate mutase-like superfamily (Table 3).\nHistidine acid phytase from all three clusters shares a large / and a small -domain . MEME analysis results in frequently observed 10 motifs (Table 4). A set of 41 amino acid residues “SPFCDLFTHEEWIQYDYLQSLGKYYGYGAGNPLGPAQGIGF” representing motif 1 were conserved and uniformly observed in 38 phytase protein sequences from clusters 1 and 2, that is, PhyA and PhyB, revealing their identity with HP_HAP like, histidine acid phosphatase superfamily. Other motifs are associated with HAP superfamily (Table 2). Cluster 3, representing AppA, does not have motif 1 in its sequences, but it does contain a 50 amino acid residues long unique motif 9 “KKGCPQSGQVAI IADVDERTRKTGEAFAAGLAPDCAITVHTQADTSSPDP.” Motif 5 “YAFLKTYNYSL GADDLTPFGEQQLVDSGIKFYQRYESLAKDIVPFIRASG” is present in all protein sequences representing PhyA cluster 1. PhyB protein sequences also contain a unique 41 amino acid residues long motif 8 “ETSPENSEGPYAGTTNALRHGAAFRARY GSLYDENSTLPVF.”\nPhylogenetic clustering and variation among biochemical features of different phytases might contribute in further classification of highly diverse HAPhys and their selection for various application purposes. Conserved sequences in motifs may be utilized for designing specific degenerate primers for identification and isolation of type and class of phytase (HAPhy) as numerous phytases are being isolated to fulfill the need of efficient phytase for feed application in various systems. 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Rechsteiner, “Amino acid sequences common to rapidly degraded proteins: the PEST hypothesis,” Science, vol. 234, no. 4774, pp. 364–368, 1986.View at: Google Scholar", "domain": "chemistry", "round": 3} +{"url": "http://www.carbideprocessors.com/pages/brazing-carbide/how-flux-affects-brazing.html", "date": "2013-05-25T00:49:33Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2013-20/segments/1368705305291/warc/CC-MAIN-20130516115505-00025-ip-10-60-113-184.ec2.internal.warc.gz", "language_score": 0.931930422782898, "token_count": 333, "dump": "CC-MAIN-2013-20", "global_id": "webtext-fineweb__CC-MAIN-2013-20__0__178938015", "lang": "en", "text": "Good & Bad Tips\nGood parts have an even flow to all four corners. The flow does not go over the sides or down the front.\nHow Much Brazing Flux to Use\nBlack Flux was used in the pictures below. See our article on brazing flux to see the different types of flux and why using black flux may solve some brazing problems.\nRemoving Brazing Flux\nBrazing flux can be removed with hot water and a little brushing. The parts can be tumbled in cold water or sandblasted. Brazing flux can also be removed by brushing. Brazing flux that is very hard to brush off while hot can sometimes be removed rather easily once it cools.\nIf you severely overheat the brazing flux it may be very hard to remove. In this case you need to add more brazing flux and reheat. The new flux will mix with the old flux and then you can remove it.\nAnti Flux – braze stops\nThere are chemical preparations sold that are applied like paint. They are designed to stop flux flow at a particular line. They generally work pretty well. Experiments can be run using Milk of Magnesia from a drugstore.\nCrystallized Brazing Flux\nThis happens rarely but when it does happen it is best not to use the flux. These are the crystals we found in the flux. I took the flux and just washed it in warm water to separate the crystals. This is out of new containers. These are 50x pictures. The metal rod is a paper clip (.032” dia.) for scale.", "domain": "chemistry", "round": 3} +{"url": "https://www.omicsdi.org/dataset/biostudies/S-EPMC7728307", "date": "2023-06-02T18:28:02Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-23/segments/1685224648850.88/warc/CC-MAIN-20230602172755-20230602202755-00448.warc.gz", "language_score": 0.8615827560424805, "token_count": 305, "dump": "CC-MAIN-2023-23", "global_id": "webtext-fineweb__CC-MAIN-2023-23__0__205165327", "lang": "en", "text": "Inhibiting the NLRP3 Inflammasome.\nABSTRACT: Inflammasomes are protein complexes which are important in several inflammatory diseases. Inflammasomes form part of the innate immune system that triggers the activation of inflammatory cytokines interleukin (IL)-1? and IL-18. The inflammasome most studied in sterile inflammation and non-communicable disease is the NLRP3 inflammasome. Upon activation by diverse pathogen or disease associated signals, NLRP3 nucleates the oligomerization of an adaptor protein ASC forming a platform (the inflammasome) for the recruitment and activation of the protease caspase-1. Active caspase-1 catalyzes the processing and release of IL-1? and IL-18, and via cleavage of the pore forming protein gasdermin D can drive pyroptotic cell death. This review focuses on the structural basis and mechanism for NLRP3 inflammasome signaling in the context of drug design, providing chemical structures, activities, and clinical potential of direct inflammasome inhibitors. A cryo-EM structure of NLRP3 bound to NEK7 protein provides structural insight and aids in the discovery of novel NLRP3 inhibitors utilizing ligand-based or structure-based approaches.\nPROVIDER: S-EPMC7728307 | BioStudies |", "domain": "chemistry", "round": 3} +{"url": "http://www.mdpi.com/2073-4441/2/3/381", "date": "2018-03-25T01:59:03Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-13/segments/1521257651481.98/warc/CC-MAIN-20180325005509-20180325025509-00080.warc.gz", "language_score": 0.8942632675170898, "token_count": 361, "dump": "CC-MAIN-2018-13", "global_id": "webtext-fineweb__CC-MAIN-2018-13__0__169133436", "lang": "en", "text": "Can a Century Old Experiment Reveal Hidden Properties of Water?\nAbstractIn 1893 Sir William Armstrong placed a cotton thread between two wine glasses filled with chemically pure water. After applying a high voltage, a watery connection formed, and after some time, the cotton thread was pulled into one of the glasses, leaving a rope of water suspended between the two glasses. Although being a very simple experiment, it is of special interest since it comprises a number of phenomena currently tackled in modern water science like electrolysis-less charge transport and nanobubbles. This work gives some background information about water research in general and describes the water bridge phenomenon from the viewpoint of different fields such as electrohydrodynamics and quantum field theory. It is shown that the investigation of the floating water bridge led to new discoveries about water, both in the macroscopic and microscopic realm – but these were merely “hidden” in that sense that they only become evident upon application of electric fields. View Full-Text\nScifeed alert for new publicationsNever miss any articles matching your research from any publisher\n- Get alerts for new papers matching your research\n- Find out the new papers from selected authors\n- Updated daily for 49'000+ journals and 6000+ publishers\n- Define your Scifeed now\nFuchs, E.C. Can a Century Old Experiment Reveal Hidden Properties of Water? Water 2010, 2, 381-410.\nFuchs EC. Can a Century Old Experiment Reveal Hidden Properties of Water? Water. 2010; 2(3):381-410.Chicago/Turabian Style\nFuchs, Elmar C. 2010. \"Can a Century Old Experiment Reveal Hidden Properties of Water?\" Water 2, no. 3: 381-410.", "domain": "chemistry", "round": 3} +{"url": "https://www.biosensis.com/mouse-monoclonal-antibody-human-mobp-403.html", "date": "2024-02-26T00:25:51Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707947474649.44/warc/CC-MAIN-20240225234904-20240226024904-00107.warc.gz", "language_score": 0.8020762205123901, "token_count": 397, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__77096486", "lang": "en", "text": "Product DescriptionMouse anti-Myelin-associated oligodendrocyte basic protein (MOBP) Monoclonal Antibody (Unconjugated), suitable for WB, ELISA.\nApplication DetailsThis antibody is recommended for WB and ELISA. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.\nTargetMyelin-associated oligodendrocyte basic protein (MOBP)\nSpecificitySpecificity has been confirmed by WB and ELISA against the antigen. Human. Other species have not been tested.\nTarget Host SpeciesHuman\nImmunogen DescriptionRecombinant human MOBP, isoform 3 [1-82], with a GST tag. Isotype is IgM Kappa.\nPurity DescriptionAscites fluid\nReconstitution InstructionsSpin vial briefly before opening. Reconstitute in 200 µL sterile-filtered, ultrapure water. Centrifuge to remove any insoluble material.\nStorage InstructionsAfter reconstitution keep aliquots at -20°C for higher stability or at 2-8°C with an appropriate antibacterial agent. Glycerol (1:1) may be added for additional stability. Avoid repetitive freeze/thaw cycles.\nBatch NumberPlease see item label.\nExpiration Date12 months after date of receipt (unopened vial).\nAlternative NamesMyelin-associated oligodendrocyte basic protein\nMOBP may play a role in compacting or stabilising the myelin sheath, possibly by binding the negatively charged acidid phospholipids of the cytoplasmic membrane. It is present in the major dense line of CNS myelin. There are 3 named isoforms produced by alternative splicing. MBP is abundantly expressed specifically in oligodendrocytes at the mRNA level. It is expressed exclusively in the CNS myelin.", "domain": "chemistry", "round": 3} +{"url": "https://directory.doabooks.org/handle/20.500.12854/67581", "date": "2023-09-30T09:41:45Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233510671.0/warc/CC-MAIN-20230930082033-20230930112033-00086.warc.gz", "language_score": 0.8565874099731445, "token_count": 257, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__91239152", "lang": "en", "text": "Thin Film for Energy Materials and Devices\nSato, Mitsunobu (editor)\nLu, Li (editor)\nNagai, Hiroki (editor)\nThe book “Lithium-ion Batteries - Thin Film for Energy Materials and Devices” provides recent research and trends for thin film materials relevant to energy utilization. The book has seven chapters with high quality content covering general aspects of the fabrication method for cathode, anode, and solid electrolyte materials and their thin films. All the chapters have been written by experts from different backgrounds, and the book is the result of collaborations between all contributing authors who agreed to share their research expertise and technological visions for the future. We hope this book will significantly stimulate readers to develop new devices.\nISBN9781789854640, 9781789854633, 9781839622977\nPublication date and place2020", "domain": "chemistry", "round": 3} +{"url": "https://scholarsarchive.byu.edu/facpub/977/", "date": "2023-05-30T18:45:13Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-23/segments/1685224646076.50/warc/CC-MAIN-20230530163210-20230530193210-00030.warc.gz", "language_score": 0.777185320854187, "token_count": 438, "dump": "CC-MAIN-2023-23", "global_id": "webtext-fineweb__CC-MAIN-2023-23__0__175729899", "lang": "en", "text": "Anisotropic high aspect ratio etch development for fluorinated polymers with stress relief technique\nanisotropy, etch, high aspect ratio, PFCB polymers\nThe authors have developed an anisotropic, high aspect ratio (18:1) etch for perfluorocyclobutyl (PFCB) polymers with trenches as narrow as 800 nm using a CO/O2 etch chemistry in an inductively coupled plasma reactive ion etcher. Anisotropy is achieved by carbon sidewall passivation. The motivation for this etch development is to use the air trenches as very compact waveguide splitters [S. Kim et al., Opt. Eng. 45, 054602 (2006)] The authors report a new trench widening mechanism due to tensile stress of the PFCB films and a method of avoiding this widening through the use of additional stress relief trenches on both sides of the desired trench.\nOriginal Publication Citation\nNazli Rahmanian, Seunghyun Kim, and Gregory P. Nordin, \"Anisotropic high aspect ratio etch development for fluorinated polymers with stress relief technique,\" J. Vac. Soc. Am. B 24(6) pp. 2572-2577 (26)\nBYU ScholarsArchive Citation\nKim, S.; Nordin, Gregory P.; and Rahmanian, N., \"Anisotropic high aspect ratio etch development for fluorinated polymers with stress relief technique\" (2006). Faculty Publications. 977.\nAmerican Vacuum Society\nIra A. Fulton College of Engineering and Technology\nElectrical and Computer Engineering\n© 2006 American Vacuum Society\nCopyright Use Information", "domain": "chemistry", "round": 3} +{"url": "https://en-academic.com/dic.nsf/enwiki/2762323", "date": "2021-04-23T16:44:14Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-17/segments/1618039596883.98/warc/CC-MAIN-20210423161713-20210423191713-00092.warc.gz", "language_score": 0.9098389744758606, "token_count": 938, "dump": "CC-MAIN-2021-17", "global_id": "webtext-fineweb__CC-MAIN-2021-17__0__232100386", "lang": "en", "text": "- Automatic transmission fluid\nAutomatic transmission fluid (ATF) is the fluid used in vehicles with self shifting or automatic transmissions. It is typically colored red or green to distinguish it from motor oil and other fluids in the vehicle. On most vehicles its level is checked with a dipstick while the engine is running.\nThe fluid is a highly specialized oil optimized for the special requirements of a transmission, such as valve operation, brake band friction and the torque converter as well as gear lubrication.\nModern ATF typically contains a wide variety of chemical compounds intended to provide the required properties of a particular ATF specification. Most ATFs contain some combination of rust preventatives, anti-foam additives, detergents, dispersants, anti-wear additives, anti-oxidation compounds, surfactants, cold-flow improvers, high-temperature thickeners, gasket conditioners, and petroleum dye.\nThere are many specifications for ATF, such as the DEXRON and MERCON series, and the vehicle manufacturer will identify the ATF specification appropriate for each vehicle. The vehicle's owner's manual will typically list the ATF specification(s) that are recommended by the manufacturer.\nAutomatic transmission fluids have many performance-enhancing chemicals added to the fluid to meet the demands of each transmission. Some ATF specifications are open to competing brands, such as the common DEXRON specification, where different manufacturers use different chemicals to meet the same performance specification. These products are sold under license from the OEM responsible for establishing the specification. Some vehicle manufacturers will require \"genuine\" or Original Equipment Manufacturer (OEM) ATF. Most ATF formulations are open 3rd party licensing, and certification by the automobile manufacturer.\nCurrent OEM formulations are made from synthetic base stocks. Each manufacturer has specific ATF requirements. Incorrect transmission fluid may result in transmission malfunction or severe damage.\n- ATF+4 - Most Dodge, Jeep, and Chrysler \n- Mercon V - Most Ford, Mercury, Lincoln\n- Mercon LV - Some Ford(DuratecHE),MAZDA in Europe or Asia\n- Dexron VI - Most GM products, some Ford applications\n- ATF DW-1 - All Honda and Acura (except CVT)\n- SP-III - All Hyundai, Mitsubishi and Kia (except CVT and dual clutch)\nSynthetic ATF is available on aftermarket brands, offering better performance and service life for certain applications (such as frequent trailer towing).\nThe use of a lint free white rag to wipe the dipstick on automatic transmissions is advised so that the color of the fluid can be checked. Dark brown or black ATF can be an indicator of a transmission problem, vehicle abuse, or fluid that has far exceeded its useful life. Overused ATF often has reduced lubrication properties and abrasive friction materials (from clutches and brake bands) suspended in it; failure to replace such fluid will accelerate transmission wear and could eventually ruin an otherwise healthy transmission. However color alone is not a completely reliable indication of the service life of an ATF as most ATF products will darken with use. The manufacturer's recommended service interval is a more reliable measure of ATF life. In the absence of service or repair records, fluid color is a common means of gauging ATF service life.\nIn the 1950s, 1960s, and 1970s, ATF contained whale oil as a friction modifier. But since whale oil would break down at higher temperatures, cars produced in the 1970s and later would not be able to use whale oil because of the higher engine coolant temperatures employed to reduce emissions and save fuel. A moratorium on whale oil at that time prevented the continued production of older ATFs such as the original DEXRON formulation (Type B), and the Type A which preceded it. General Motors began marketing Dexron II Type C and later Dexron II Type D to replace the whale oil-derived fluids.\nMotor fuels Fuel types Fuel additivesButyl rubber • Butylated hydroxytoluene • 1,2-Dibromoethane • 1,2-Dichloroethane • Dimethyl methylphosphonate • 2,4-Dimethyl-6-tert-butylphenol • Dinonylnaphthylsulfonic acid • 2,6-Di-tert-butylphenol • Ecalene • Ethylenediamine • Metal deactivator • Methyl tert-butyl ether • Nitromethane • Tetraethyllead • Tetranitromethane Fluids Retail\nWikimedia Foundation. 2010.", "domain": "chemistry", "round": 3} +{"url": "https://innovations.unm.edu/2019/01/01/inventor-spotlight-hongyou-fan-ph-d/", "date": "2023-12-04T10:19:34Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100527.35/warc/CC-MAIN-20231204083733-20231204113733-00333.warc.gz", "language_score": 0.89555823802948, "token_count": 308, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__30356801", "lang": "en", "text": "Dr. Fan’s current research focuses on the development of new synthesis methods and self-assembly processes to fabricate multifunctional nanomaterials; fundamentally understanding self-assembly mechanisms and structural evolution from the molecular to the nano- and micro-scale scale; and understanding structure-property relationships.\nISSUED U. S. PATENTS (UNM-AFFILIATED)\n6,471,761 Prototyping of Patterned Functional Nanostructures, issued October 29, 2002\n6,808,867 Photo-Definable Self-Assembled Materials, issued October 26, 2004\n6,913,832 Prototyping of Patterned Functional Nanostructures, issued July 5, 2005\n7,332,264 Photo-Definable Self-Assembled Materials, issued February 19, 2008\n8,092,595 Self-Assembly of Water Soluble Nanocrystals, issued January 10, 2012\n8,288,001 Method of Making Monodisperse Nanoparticles, issued October 16, 2012\n8,425,981 Method of Making Nanoporous, Hydrophobic Coatings, issued April 23, 2013\n8,871,926 Synthesis of Porphyrin Nanostructures, issued October 28, 2014\nTechnologies listing this individual as an inventor, may be found at the UNM Flintbox Researcher page. Each of the respective technologies will display updated patent and publication information.", "domain": "chemistry", "round": 3} +{"url": "http://koreascience.or.kr/article/JAKO201719558338270.page", "date": "2020-07-10T03:55:08Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-29/segments/1593655902496.52/warc/CC-MAIN-20200710015901-20200710045901-00122.warc.gz", "language_score": 0.7158406972885132, "token_count": 2475, "dump": "CC-MAIN-2020-29", "global_id": "webtext-fineweb__CC-MAIN-2020-29__0__23908808", "lang": "en", "text": "- Volume 15 Issue 6\nDOI QR Code\nBiocidal Effects of Chlorine Dioxide on Isolated and Identified Pathogens from Nosocomial Environment - Biochemical and Technical Covergence\n병원내 환경으로부터 분리 및 확인된 병원균에 대한 이산화염소의 살균 효과 - 생화학 및 기술 융합\n- Song, Kyoung-Ju (Purgofarm Co. Ltd) ;\n- Jung, Suk-Yul (Molecular Diagnostics Research Institute, Dept. of Biomedical Laboratory Science, Namseoul University)\n- Received : 2017.05.01\n- Accepted : 2017.06.20\n- Published : 2017.06.28\nIn this study, microorganisms were isolated from nosocomial environment and are identified by biochemical analysis as the part of biochemical and technical convergence. Microorganisms were collected at intense care unit of general hospital located in Pyeongtak (2014.11.28. - 2014. 11. 30). Using a VITEK2 equipment of biochemical approaches, eleven microorganisms e.g., Micrococcus luteus (or M. lylae), Granulicatella adiacens (M. luteus or M. lylae), Staphylococcus caprae, Sphingomonas paucimobilis, Kocuria kristinae, G elegans, Aerococcus viridans (or Staphylococcus arlettae), Methylobacterium spp., Dermacoccus nishinomiyaensis (or Kytococcus sedentarius), Kocuria kristinae (or M. luteus, M. lylae), Pseudomonas oryzihabitans were identified. And then identified bacteria plates were applied with a plastic stick, so called with \"FarmeTok (medistick/Puristic) to produce ClO2. ClO2-releasing plastic stick showed the very strong inhibition of bacterial growth with about 99.9%. There were no bacterial colonies on the ClO2-incubated plate. Taken together, it is suggested that chlorine dioxide should be very strong inhibitor to microorganisms of nosocomial infections.\nSupported by : Namseoul University\n- H. Vogt, J. Balej, J. E. Bennett, P. Wintzer, S. A. Sheikh, P. Gallone, S. Vasudevan, K. Pelin, Chlorine oxides and chlorine oxygen acids, Ullmann's Encyclopedia of Industrial Chemistry, Wiley-VCH, 2010.\n- L. O. Brockway, \"The three-electron bond in chlorine dioxide\", Proc. Natl. Acad. Sci. USA, vol. 19, No. 3, pp. 303-307, 1933. https://doi.org/10.1073/pnas.19.3.303\n- R. Flesch, J. Plenge, E. Ruhl, \"Core-level excitation and fragmentation of chlorine dioxide\", Int. J. Mass Spectrometry, Vol. 249-250, pp. 68-76, 2006. https://doi.org/10.1016/j.ijms.2005.12.046\n- T. Sanekata, F. Fukuda, T. Miura, H. Morino, C. Lee, K. Maeda, K. Araki, T. Otake, T. Kawahata, T. Shibata, \"Evaluation of the antiviral activity of chlorine dioxide and sodium hypochlorite against feline calicivirus, human influenza virus, measles virus, canine distemper virus, human herpesvirus, human adenovirus, canine adenovirus and canine parvovirus\", Biocontrol. Science, Vol. 15, No. 2, pp. 45-49, 2010. https://doi.org/10.4265/bio.15.45\n- N. Ogata, T. Shibata, \"Protective effect of low-concentration chlorine dioxide gas against influenza a virus infection\", J. Gen. Virology, Vol. 89, No. 1, pp. 60-67, 2008. https://doi.org/10.1099/vir.0.83393-0\n- H. Morino, T. Fukuda, T. Miura, C. Lee, T. Shibata, T. Sanekata, \"Inactivation of feline calicivirus, a norovirus surrogate, by chlorine dioxide gas\", Biocontrol. Science, Vol. 14, No. 4, pp. 147-153, 2009. https://doi.org/10.4265/bio.14.147\n- J. W. Ma, B. S. Huang, C. W. Hsu, C. W. Peng, M. L. Cheng, J. Y. Kao, T. D. Way, H. C. Yin, S. S. Wang, \"Efficacy and Safety Evaluation of a Chlorine Dioxide Solution\", Int. J. Environ. Res. Public Health, Vol. 14, No. 3, pp. 329, 2017. https://doi.org/10.3390/ijerph14030329\n- I. Ofori, S. Maddila, J. Lin, S. B. Jonnalagadda, \"Chlorine dioxide oxidation of Escherichia coli in water - A study of the disinfection kinetics and mechanism\", J. Environ. Sci. Health. A. Tox. Hazard. Subst. Environ. England, Vol. 1-9, 2017. [Epub ahead of print].\n- J. H. Kang, K. B. Song, \"Combined treatment on the inactivation of naturally existing bacteria and Escherichia coli O157:H7 inoculated on fresh-cut Kale\", J. Microbiol. Biotechnology, Vol. 27, No. 2, pp. 219-225, 2017. https://doi.org/10.4014/jmb.1607.07029\n- R. Nogueira, K. U. Utecht, M. Exner, W. Verstraete, K. H. Rosenwinkel. \"Strategies for the reduction of Legionella in biological treatment systems\", Water. Sci. Technology, Vol. 74, No. 4, pp. 816-823, 2016. https://doi.org/10.2166/wst.2016.258\n- A. S. Breathnach, \"Nosocomial infections\", Medicine, Vol. 37, No. 10, pp. 557-561, 2009. https://doi.org/10.1016/j.mpmed.2009.07.008\n- S. Y. Jeong, O. S. Kim, J. Y. Lee, \"The status of Healthcare-associated Infection Control among Healthcare Facilities in Korea\" J. Digital Policy & Management, Vol. 12, No. 5, pp. 353-366, 2014.\n- S. W. Jeung, C. H. Lim, I. G. You, \"A Study on the Measurement of Bacterial Contamination of MRI Examination Equipment and Disinfection Conditions\", J. Digital Policy & Management, Vol. 11, No. 12, pp. 665-672, 2013.\n- C. W. Seo, Y. B. Yu, K. S. Shin, Y. K. Kim, \"Distribution of Yeast Isolated from Clinical Specimens at a University Hospital in last Five Years, J. Digital Policy & Management, Vol. 12, No. 9, pp. 237-244, 2014.\n- P. K. Shin, \"A convergence study the association between addictive smart phone use, dry eye syndrome, upper extremity pain and depression among college students', J. Korea Converg. Soc., Vol. 8, No. 1, pp. 61-69, 2017. https://doi.org/10.15207/JKCS.2017.8.1.061\n- J. J. Lowe, S. G. Gibbs, P. C. Iwen, P. W. Smith, A. L. Hewlett, \"Impact of Chlorine Dioxide Gas Sterilization on Nosocomial Organism Viability in a Hospital Room\", Int. J. Environ. Res. Public Health, Vol. 10, No. 6, pp. 2596-2605, 2013. https://doi.org/10.3390/ijerph10062596\n- K. S. Yao, Y. H. Hsieh, Y. J. Chang, C. Y. Chang, T. C. Cheng, H. L. Liao, \"Inactivation effect of chlorine dioxide on phytophathogenic bacteria in irrigatin water\", J. Environ. Eng. Management, Vol. 20, No. 3, pp. 157-160, 2010.\n- X. W. Wang, J. S. Li, M. Jin, B. Zhen, Q. X. Kong, N. Song, W. J. Xiao, J. Yin, W. Wei, G. J. Wang, B. Y. Si, B. Z. Guo, C. Liu, G. R. Ou, M. N. Wang, T. Y. Fang, F. H. Chao, J. W. Li, \"Study on the resistance of severe acute respiratory syndrome-associated coronavirus\", J. Virol. Methods, Vol. 126, No. 1-2, pp. 171-177, 2005. https://doi.org/10.1016/j.jviromet.2005.02.005\n- C. Chen, X. J. Zhang, Y. Wang, L. X. Zhu, J. Liu, \"Waste water disinfection during SARS epidemic for microbiological and toxicological control\", Biomed. Environ. Science, Vol. 19, No. 3, pp. 173-178, 2006.\n- K. M. Yang, \"The effect of self-esteemand depression on smartphone addiction among university students\", J. Korea Converg. Soc., Vol. 7, No. 1, pp. 113-123, 2016. https://doi.org/10.15207/JKCS.2016.7.1.113\n- J. L. Cui, M. H. Chey, S. I. Kim, \"Seismic performance of urban structures with various horizontal irregularities using equivalent static analysis\", J. IT Converg. Soc. SMB, Vol. 6, No. 1, pp. 25-32, 2016.\n- H. J. Oh, H. Y. Doo, S. H. Sim, S. M. Choi, S. J. Oh, \"The Study of tear film stability for normal eyes in adults\", J. IT Converg. Soc. SMB, Vol. 6, No. 4, pp. 93-98, 2016. https://doi.org/10.22156/CS4SMB.2016.6.4.093", "domain": "chemistry", "round": 3} +{"url": "http://lisbic.com/on-koneramine/", "date": "2019-05-21T17:13:44Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-22/segments/1558232256494.24/warc/CC-MAIN-20190521162634-20190521184634-00217.warc.gz", "language_score": 0.6719832420349121, "token_count": 455, "dump": "CC-MAIN-2019-22", "global_id": "webtext-fineweb__CC-MAIN-2019-22__0__16499459", "lang": "en", "text": "“Diastereoselective Formation of Koneramine Complexes from Multicomponent One-Pot Reactions Hampered by Me”,\nwhere metal free Koneramine will be seen for the first time…\nK. Mani, S. Raje, H. Gupta, A. Prasad, P. Pal, S. Mehrotra and R. Angamuthu*\n. M. Chahal, K. Mani, C. S. Lodhi, R. J. Butcher, R. Angamuthu* and S. Raje*. Metal Dependent Formation of Imidazolidine or Hemiaminal Ether Complexes from Multicomponent One-pot Reactions.ChemistrySelect 2018, 3, 9960-9964.\n. S. Raje* and R. Angamuthu. Tetranuclear nickel cubane cluster formed by the hydrolysis of nickel koneramine complex. Inorg. Chim. Acta., 483 (2018) 258–261.\n S. Raje, N. Mondivagu, M. Chahal, R. J. Butcher, R. Angamuthu. Mechanism of Evolution of Koneramine Complexes from One‐Pot Reactions: Snapshots of Intermediates Offer Facile Routes to New Dipicolylamines. Chem. Asian. J. 2018, 13, 1458-1466.\n S. Raje, K. Mani, M. M. Parsutkar, R. Angamuthu. Metal ions as external stimuli in stereoselective self-sorting of koneramines and thiokoneramines. New J. Chem. 2017, 12303-12308.\n S. Raje, S. Gurusamy, A. Koner, S. Mehrotra, S. J. Jennifer, P. G. Vasudev, R. J. Butcher, R. Angamuthu. Multicomponent One-pot Reactions Towards the Synthesis of Stereoisomers of Dipicolylamine Complexes. Chem. Asian. J. 2016, 11, 128-135.", "domain": "chemistry", "round": 3} +{"url": "http://cxassignmenthook.designheroes.us/thesis-gasification.html", "date": "2018-11-15T06:50:42Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-47/segments/1542039742567.46/warc/CC-MAIN-20181115054518-20181115080518-00212.warc.gz", "language_score": 0.9136781692504883, "token_count": 1260, "dump": "CC-MAIN-2018-47", "global_id": "webtext-fineweb__CC-MAIN-2018-47__0__90766542", "lang": "en", "text": "Coal gasification phd thesis coal gasification phd thesis coal gasification phd gasification phd thesis thesis on their thesis the views expressedscribd is the worlds largest social reading and. Title = biomass gasification for the production of methane, abstract = biomass is very promising as a sustainable alternative to fossil resources because it is a renewable source that contains carbon, an essential building block for gaseous and liquid fuels. This thesis is based on the fuel characterisation work carried out in the gasification research group at vtt, begun in the late 1980s with peat, continued with biomass, and.\nThesis for the degree of doctor of philosophy black liquor gasification-based biorefineries – determining factors for economic performance. Thesis are not limited to the self-gasification concept where methane is the final product, but give valuable information for other biomass gasification process- es as well. Plasma gasification analysis of low rank south african coals - kiashen nayagar - master's thesis - chemistry - bio-chemistry - publish your bachelor's or master's thesis, dissertation, term paper or essay gasification is an environmentally friendly technique to transform any carbon based raw material into usable energy without burning it.\nThe research described in this thesis deals with steam reforming and gasification of pyrolysis oil to produce syngas/hydrogen by producing syngas and/or hydrogen, biomass can be linked to the existing fossil based petrochemical industry and can serve as a source of hydrogen for a rapidly growing market. Aspen plus simulation and experimental studies on biomass gasification this thesis is submitted in the partial fulfillment of the requirement for the degree. Coal gasification phd thesis coal gasification phd thesis gasification phd thesis gasification phd thesis clean heat and power using biomass gasification for industrial and agricultural projects february 2010 prepared by: carolyn j roos, phdtake the next step in your careergasification of coal is one of the available alternatives.\n( 1 996) (germany) report on the all-thermal gasification of biomass in a fluidized bed reactor that is activated by steam fed from the bottom 1 998) (italy) catalytic steam gasification of biomass was studied in a bench-scale plant containing a fluidized-bed gasifier and a. Gasification phd thesis gasification phd thesis coal gasification phd thesis influence thesis on coal gasification of water vapor on silica cheap paper lanterns bulk uk membranes: thesis topics, project sample downloadsgasification phd thesis biomass gasification phd thesispaper writers onlinephysics homework helpbuy essay papers on linebuy custom essay uktake the next step. A thesis by ramkumar jayakumar submitted to the office of graduate studies of texas a&m university common processes for power generation, namely combustion and gasification, were developed using aspen plus steady state chemical process simulator overall plant. Modelling of biomass steam gasification in a bubbling fluidized bed gasifier a thesis submitted in fulfilment of the requirements for the degree of doctor of philosophy in gasification reactions and two-dimensional cfd model for hydrodynamics characteristics. Coal gasification phd thesis coal gasification phd thesis coal gasification phd thesis its the only one that works for me except for clarinex which i avoid critical essays importance of being earnest uga application essaybest research paper best research paper proofreading websites ca.\nAssessing the suitability of various feedstocks for biomass gasification a thesis submitted to the graduate faculty of the louisiana state university and agriculture and mechanical college in partial fulfillment of the requirements for the degree of master of science in biological and agricultural engineering in the department of biological and agricultural engineering. Research output: thesis doctoral thesis abstract although the general principles of biomass gasification are broadly understood, at a larger scale of operation (eg 200 kg/h) there is a lack of confidence in the translation of the basic scientific concepts into a financially viable operation that satisfies regulatory requirements. This thesis concludes that waste gasification is a viable and cost competitive alternative to the combustion of rdf however, the dearth of commercial gasification plants, and the. Master’s thesis production of activated carbon within the indirect production of activated carbon within the indirect gasification process master’s thesis within the sustainable energy systems programme within the indirect gasification process is investigated. Coal gasification phd thesis coal gasification phd thesis introduction an integrated gasification combined cycle, or igcc, is a power plant using synthetic gas (syngas).\nModeling and optimization of biomass gasification systems by luca carlassara, this work is performed as master thesis in engineering design and applied mechanics and is based on an modeling and optimization of biomass gasification systems 4. Abstract the objective of this thesis is to design and optimize the integrated plasma gasification combined cycle utilizing municipal solid waste as fuel in tiruchirappalli, india. Thesis, the fuel cycle ghg emissions of power generation from both dedicated biomass power plants and coal power plants with biomass co-firing are quantified using a model based on argonne national laboratory’s greet model.\nGasification experiments and studies definition gasification is a chemical-heat process that converts energy materials like coal and biomass into gas: a mixture of carbon monoxide with hydrogen which is called syngas that is used as a clean fuel. Both through digestion of eg manure and gasification of lignocellulosic biomass since 2008, the new so-called sde programme is in place, that subsidizes the producer of renewable energy: power, heat and gas the total 2013 budget for subsidy is 3 billion euro the government is preparing an obligation system for power suppliers. The present ph d thesis describes experimental and modeling investigations on entrained flow gasification of biomass and an experimental investigation on entrained flow co- gasification of biomass and coal. Any use made of information contained in this thesis/dissertation must be in accordance with that legislation and must be properly acknowledged further distribution or reproduction in any format is prohibited without the permission of the copyright holder.", "domain": "chemistry", "round": 3} +{"url": "http://en.ftxt-e.com/about/companynews-detail-540.htm", "date": "2023-11-28T10:12:52Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679099281.67/warc/CC-MAIN-20231128083443-20231128113443-00361.warc.gz", "language_score": 0.92851322889328, "token_count": 277, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__19754859", "lang": "en", "text": "Recently, the FTXT's IV hydrogen storage tank production line was officially completed in Baoding Industrial Park and entered the trial production stage, marking that FTXT has the large-scale production capacity of the Type IV hydrogen storage tank and has taken a surprising leap in industrialization development.\nThe production line workshop covers an area of more than 4,000 square meters and has introduced high-end fully automated intelligent production lines. The whole production line includes a complete production process, such as inner liner forming, surface treatment, fiber winding, curing, inspection and testing, product packaging, etc. And the physical, chemical, and mechanics laboratory can carry out the physicochemical and mechanical evaluation experiments of metal and non-metal materials, such as inner liner material, inner liner, valve seat, aluminum alloy, sealing ring, checking ring, carbon fiber, glass fiber, epoxy resin composite material. This production line facilitates FTXT to realize the closed-loop control of the whole process from design and development to quality inspection, ensuring product consistency, reliability, and safety.\nAfter the project is put into operation, the production capacity of the hydrogen storage tank can reach 10,000 pcs/year, which is expected to be officially put into production at the end of 2023 for global market supply. By 2026, the planned production capacity will be expanded to 100,000 tanks per year.", "domain": "chemistry", "round": 3} +{"url": "https://www.plantedtank.net/forums/8-general-planted-tank-discussion/1254097-overkilling-co2.html", "date": "2020-05-26T13:17:15Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-24/segments/1590347390758.21/warc/CC-MAIN-20200526112939-20200526142939-00098.warc.gz", "language_score": 0.9293156266212463, "token_count": 255, "dump": "CC-MAIN-2020-24", "global_id": "webtext-fineweb__CC-MAIN-2020-24__0__114617103", "lang": "en", "text": "Yes, if you make the water too acidic, you can kill your plants. Just do a 1 or 1.5 degree pH drop. So measure pH when tank is completely off gassed, then measure pH after several hours of CO2 injection. Plant a lot of DHG off the get go. It can be demanding, sounds like you've got all the ingredients for success. Also, start with no more than 5 hours at 100% strength light until you have some plant mass built up, then you can start ramping up time slowly at that point.\nDo not inject CO2 directly into your filter, air hitting the impeller constantly isn't good. Get yourself a 3 pack of in-tank glass diffusers. They'll need frequent bleach baths to keep pores clean so that's why the 3 pack is nice.\nTo achieve growth, you need micros and macros, so NPK are your macros, CSM+B or Miller's Complex for your micro mix. Good light and adequate CO2 with that and you're golden. Be patient. Don't ramp that light up past 5 hours until there's plenty of mass and if you start seeing algae, go down to 4 hours. 50% weekly water changes if you're dosing EI", "domain": "chemistry", "round": 3} +{"url": "http://www.palomid529.com/2022/07/31/%EF%BB%BFthe-recombinant-proteins-his-vcam-1-and-gst-vcam-1-were-analysed-by-12-sds-page-and-western-blot-using-monoclonal-antibodies-against-the-his-and-gst-tags-sigma-usa-respectively/", "date": "2022-10-03T12:37:14Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-40/segments/1664030337415.12/warc/CC-MAIN-20221003101805-20221003131805-00587.warc.gz", "language_score": 0.9412559866905212, "token_count": 1378, "dump": "CC-MAIN-2022-40", "global_id": "webtext-fineweb__CC-MAIN-2022-40__0__113426213", "lang": "en", "text": "The recombinant proteins His-VCAM-1 and GST-VCAM-1 were analysed by 12% SDS-PAGE and Western blot using monoclonal antibodies against the His and GST tags (Sigma, USA) respectively. titre examined by indirect ELISA was 128,000 using GST-VCAM-1 as the well layer antigen. Traditional western blots indicated how the antibody recognized recombinant VCAM-1 proteins aswell as endogenous VCAM-1. Furthermore, BNC105 using qPCR and Traditional western blot, VCAM-1 protein and mRNA expression levels were measured in dairy cows with subclinical mastitis. It was proven that VCAM-1 amounts in the mammary lymph nodes from the cows had been significantly greater than those from healthful settings (P 0.05). Summary These email address details are to our understanding the first record that VCAM-1 manifestation in the mammary lymph nodes can be elevated in dairy products cows with subclinical mastitis. (sp. Additionally, little intestine Peyers areas had been isolated from healthful dairy products cows. All bovine cells had been kept at C80C in the super-cold refrigerator. Wistar rats (180C220 g) had been supplied by the Experimental Pet Middle of Jilin College or university (Changchun, China). Cloning and recognition from the VCAM-1 gene in RI and I and put in to the His and GST fusion proteins sites from the prokaryotic manifestation vectors pGEX-4T-1 and pET-28a (Takara) respectively, to generate the recombinant plasmids pET-28a/VCAM-1 and pGEX-4T-1/VCAM-1. To be able to attain fusion proteins manifestation, the recombinant plasmids had been changed into BL21 (DE3) and induced with 1 mM isopropyl–D-thiogalactopyranoside (IPTG) at 37C for 4 h. The recombinant cells had been harvested by broadband centrifugation after IPTG induction. Evaluation of rVCAM-1 proteins solubility The accomplished pellet was gathered as referred to above, then your pellet was sonicated by ultrasonic program CPX- 600 (Cole-Parmer, USA). First of all, the cell pellet was resuspended in PBS and cooled on snow for 10 min. After that, cell suspension system was sonicated with 10 BNC105 brief bursts of 10 s accompanied by period of 30 s for chilling. Finally, the lysate was ultracentrifuged at 4oC for 10 min at 12,000 rpm. For verification of rVCAM-1 manifestation, the supernatant as well as the precipitates had been analysed by SDS-PAGE. Purification from the recombinant VCAM-1 proteins Recombinant VCAM-1 proteins using the His label was purified using His GraviTrap (GE Biosciences, Sweden) and recombinant VCAM-1 proteins using the GST label was purified using Gluthathione-Sepharose 4B (GE Health care, USA), following package protocols for both BNC105 purifications. The recombinant proteins His-VCAM-1 and GST-VCAM-1 had been analysed by 12% SDS-PAGE and Traditional western blot using monoclonal antibodies against the His and GST tags (Sigma, USA) respectively. The proteins concentrations of both purified recombinant proteins had been determined utilizing a BCA proteins package (Bio-Rad, USA). Planning of polyclonal antibodies against recombinant bovine His-VCAM-1 proteins in rats Wistar rats had been immunised with 50 g of purified recombinant bovine His-VCAM-1 proteins emulsified in full Freunds adjuvant (Sigma, USA) on day time 1. Intramuscular booster shots in the same dosage had been administered on times 14, 28, 35, and 42. The rats had been euthanised and bloodstream was gathered on day time 7 following the last immunisation. Polyclonal antibodies against bovine VCAM-1 had been kept and ready at ?20C until use. Recognition of anti-VCAM-1 polyclonal antibody titre by ELISA ELISA plates had been covered with 2 g/mL of recombinant His-VCAM-1 proteins in PBS and incubated over night at 4C. After cleaning five moments with PBS-0.05% Tween 20 (PBS-T), non-specific binding sites were blocked with PBS containing 3% bovine serum albumin for 1?h in 37C. Wells had been after that incubated with 50 L of serum examples at different dilutions for 1 h at 37C. The microplate was cleaned five moments in PBS-T, incubated with phosphatase-labelled goat anti-rat IgG (Sigma, USA) for 1 h at space temperature, and washed five moments with PBS-T then. Finally, the response was developed with the addition of disodium 4-nitrophenyl phosphate substrate (Sigma), as well as the absorbance was assessed at 405 nm inside a microplate audience (Bio-TEK, USA). All serum examples had been examined in triplicate on each dish. Recognition of recombinant VCAM-1 proteins using anti-bovine VCAM-1 polyclonal antibody by Traditional western blot After recombinant VCAM-1 proteins was determined by 12% SDS-PAGE, the gel was used in nitrocellulose membrane. The membrane was incubated with anti-bovine VCAM-1 polyclonal goat and antibody anti-rat IgG. The experimental approach to Western and SDS-PAGE blot was performed as previously referred to. Primers of VCAM-1 for real-time PCR A set of primers was designed predicated on the VCAM-1 gene series (GenBank accession no. 174484.1; amplicon size 80 bp) with PrimerExpress 3.0 UBE2T (ABI, USA). The primer sequences had been the following: ahead primer C 5-TGA CGA TGA CGT GTG CCA GT-3; opposite primer C 5-GCT GTC GGT TCC CAT TGT CT-3. The primers had been synthesised by Sangon Biotech (China). Primers of -actin for real-time PCR A set of primers was designed predicated on the -actin gene.", "domain": "chemistry", "round": 3} +{"url": "http://www.colorado.edu/chbe/andrew-p-goodwin", "date": "2017-08-22T18:46:02Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-34/segments/1502886112539.18/warc/CC-MAIN-20170822181825-20170822201825-00131.warc.gz", "language_score": 0.7126462459564209, "token_count": 2308, "dump": "CC-MAIN-2017-34", "global_id": "webtext-fineweb__CC-MAIN-2017-34__0__126623415", "lang": "en", "text": "B.A., Columbia University (2002)\nPh.D., University of California, Berkeley (2007)\n- NIH Director's New Innovator Award, 2014-2019\n- NIH K99 Pathway to Independence Award in Cancer Nanotechnology, 2010-2015\n- DOD Breast Cancer Postdoctoral Fellowship Award, 2010-2013\n- AACR Scholar-in-Training Award, 2011\n- NIH T32 Postdoctoral Fellowship, 2008-2010\n- R. Chattaraj, G. M. Goldscheitter, A. Yildirim, and A. P. Goodwin.* \"Enhanced Acoustic Vaporization of Perfluorocarbon Nanodroplets due to Phase Behavior of Mixed Lipid Monolayers.\" In revision.\n- K. Kumar, E. J. Castano, A. R. Weidner, A. P. Goodwin.* “Depolymerizable Poly(vinyl carbamate-alt-sulfones) as Customizable Macromolecular Mucosal Drug Delivery Scaffolds.” In revision.\n- Yildirim, R. Chattaraj, N. T. Blum, G. M. Goldscheitter, and A. P. Goodwin.* \"Stable Encapsulation of Air in Mesoporous Silica Nanoparticles: Fluorocarbon-Free Nanoscale Ultrasound Contrast Agents.\" Adv. Healthcare Mater. 2016, in press.\n- D. W. Domaille,* G. R. Hafenstine, M. A. Greer, A. P. Goodwin,* and J. N. Cha.* “Catalytic Upgrading in Bacteria-Compatible Conditions via a Biocompatible Aldol Condensation.” ACS Sustainable Chem. Eng. 2016, 4, 671-675.\n- R. Chattaraj, P. Mohan, C. R. Livingston, J. D. Besmer, K. Kumar, and A. P. Goodwin.* “Mutually-Reactive, Fluorogenic Reporter Molecules for In-Solution Biosensing via Droplet Association.” ACS Appl. Mater. Inter. 2016, 8, 802-808.\n- K. Kumar and A. P. Goodwin.* “Alternating Sulfone Copolymers Depolymerize in Response to Both Chemical and Mechanical Stimuli.” ACS Macro Lett. 2015, 4, 907-911.\n- R. Chattaraj, P. Mohan, J. D. Besmer, and A. P. Goodwin.* “Selective Vaporization of Superheated Nanodroplets for Rapid, Sensitive Acoustic Biosensing.” Adv. Healthcare Mater. 2015, 4, 1790-1795.\n- A. P. Goodwin.* “Novel polymer-lipid assemblies for stimulus-responsive imaging contrast agents.” J. Acoust. Soc. Am. 2015, 137, 2397.\n- A. P. Goodwin,* M. A. Nakatsuka, and R. F. Mattrey.* “Stimulus-Responsive Ultrasound Contrast Agents for Clinical Imaging: Motivations, Demonstrations, and Future Directions.” WIREs Nanomed. Nanobiotechnol. 2015, 7, 111-123.\n- G. R. Hafenstine, D. W. Domaille, J. N. Cha,* and A. P. Goodwin.* “Self-Assembly and Reassembly of Fiber-forming Dipeptides for pH-Triggered DNA Delivery.” J. Polym. Sci. A. 2015, 53, 183-187.\n- K. R. Fitch and A. P. Goodwin.* “A Mechanochemical Reaction Cascade for Sensitive Detection of Covalent Bond Breakage in Hydrogels.” Chem. Mater. 2014, 26, 6771-6776.\n- P. Mohan, P. S. Noonan, M. A. Nakatsuka, and A. P. Goodwin.* “On-Demand Droplet Fusion: A Strategy for Stimulus-Responsive Biosensing in Solution.” Langmuir. 2014, 30, 12321–12327.\n- P. S. Noonan, P. Mohan, A. P. Goodwin, and D. K. Schwartz.* \"DNA Hybridization-Mediated Liposome Fusion at the Aqueous-Liquid Crystal Interface.\" Adv. Func. Mater. 2014, 24, 3206-3214.\n- H. Noh, S. Goodman, P. Mohan, A. P. Goodwin, P. Nagpal, and J. N. Cha.* \"Direct conjugation of DNA to quantum dots for scalable assembly of photoactive thin films.\" RSC Adv. 2014, 4, 8064-8071.\n- M. A. Nakatsuka, C. V. Barback, K. R. Fitch, A. R. Farwell, R. F. Mattrey, S. C. Esener, J. N. Cha, and A. P. Goodwin.* \"In Vivo Ultrasound Visualization of Non-Occlusive Blood Clots with Thrombin-Sensitive Contrast Agents.\" Biomaterials. 2013, 34, 9559-9565.\n- P. F. Xu, H. Noh, J. H. Lee, D. W. Domaille, M. A. Nakatsuka, A. P. Goodwin,* and J. N. Cha.* \"Imparting the unique properties of DNA into complex material architectures and functions.\" Mater. Today. 2013, 16, 290-296.\n- S. Chapman, et al. \"Nanoparticles for cancer imaging: The good, the bad, and the promise.\" Nano Today. 2013, 8, 454-460.\n- M. A. Nakatsuka, R. F. Mattrey, S. C. Esener, J. N. Cha,* and A. P. Goodwin.* \"Aptamer-Crosslinked Microbubbles: Smart Contrast Agents for Thrombin-Activated Ultrasound Imaging.\" Adv. Mater. 2012, 24, 6010-6016.\n- M. A. Nakatsuka, M. J. Hsu, S. C. Esener,* J. N. Cha,* and A. P. Goodwin.* “DNA-Coated Microbubbles with Biochemically-Tunable Ultrasound Contrast Activity.” Adv. Mater. 2011, 23, 4908-4912.\n- M. A. Nakatsuka, J. H. Lee, E. Nakayama, A. M. Hung, M. J. Hsu, R. F. Mattrey, S. C. Esener,* J. N. Cha,* and A. P. Goodwin.* “Facile One-Pot Synthesis of Polymer-Phospholipid Composite Microbubbles with Enhanced Drug Loading Capacity for Ultrasound-Triggered Therapy.” Soft Matter. 2011, 7, 1656-1659.\n- M. J. Hsu, M. Eghtedari, A. P. Goodwin, R. F. Mattrey, D. J. Hall, and S. C. Esener. “Characterization of individual ultrasound microbubble dynamics with a light-scattering system.” J. Biomed. Opt. 2011, 16, 067002.\n- A. P. Goodwin, S. M. Tabakman, K. Welsher, S. P. Sherlock, G. Prencipe, and H. Dai. “Phospholipid-Dextran with a Single Coupling Point: a Useful Amphiphile for Functionalization of Nanomaterials.” J. Am. Chem. Soc. 2009, 131, 289-296.\n- Z. Chen, S. M. Tabakman, A. P. Goodwin, M. G. Kattah, D. Daranciang, X. Wang, G. Zhang, X. Li, Z. Liu, P. J. Utz, K. L. Jiang, S. S. Fan, and H. Dai. “Protein microarrays with carbon nanotubes as multicolor Raman labels.” Nature Biotechnol. 2008, 26, 1285-1292.\n- A. P. Goodwin, S. S. Lam, J. M. J. Fréchet. “Rapid, Efficient Synthesis of Heterobifunctional Biodegradable Dendrimers.” J. Am. Chem. Soc. 2007, 129, 6994-6995.\n- J. L. Mynar, A. P. Goodwin, J. A. Cohen, Y-Z. Ma, G. R. Fleming, J. M. J. Fréchet. “Two-photon Degradable Supramolecular Assemblies of Linear-Dendritic Copolymers.” Chem. Commun. 2007, 20, 2081-2082.\n- A. P. Goodwin, J. L. Mynar, Y-Z. Ma, G. R. Fleming, J. M. J. Fréchet. “Synthetic Micelle Sensitive to IR Light Via a Two-Photon Process.” J. Am. Chem. Soc. 2005, 127, 9952-9953.\n- E. R. Gillies, A. P. Goodwin, J. M. J. Fréchet. “Acetals as pH-Sensitive Linkages for Drug Delivery.” Bioconjugate Chem. 2004, 15, 1254-1263.\n* indicates corresponding author\nColloid and interface science, polymer science and engineering, self-assembly, chemical synthesis, imaging, drug delivery, cancer research.\nOur research is focused on the interplay between chemical properties at the molecular scale and materials properties at the nano- and microscale. Through careful design of interfacial structure and function, we are creating “smart” colloids and materials – such as polymeric architectures, organic/inorganic hybrids, and multiphase composites – that can sense their surroundings and react accordingly. This reaction results in transmission of information, release of encapsulated contents, or change of local surface and material properties, and applications for such systems include imaging, drug delivery, catalysis, sensing, and renewable materials, among others. We are also interested in how interfaces organize themselves when sensing chemical stimuli, and how they respond to external forces. We are exploring these phenomena in both natural and synthetic systems through a combination of chemical design, colloid and surface engineering, and microscopy.", "domain": "chemistry", "round": 3} +{"url": "https://nevinmanimala.com/2023/11/02/application-of-laser-treatment-in-adhesive-bonding-of-liners-to-polymethyl-methacrylate-denture-resins-a-systematic-review-and-meta-analysis/", "date": "2023-12-04T19:11:06Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100534.18/warc/CC-MAIN-20231204182901-20231204212901-00836.warc.gz", "language_score": 0.9287186861038208, "token_count": 502, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__185760884", "lang": "en", "text": "Photobiomodul Photomed Laser Surg. 2023 Oct 31. doi: 10.1089/photob.2023.0066. Online ahead of print.\nObjective: This systematic review and meta-analysis aimed to assess the influence of laser treatment on adhesive bonding of liners to polymethyl methacrylate (PMMA) denture base resins. Methods: The focused question was: “Does the application of laser treatment (Intervention) influence the adhesive bonding strength (Outcome) of liners to PMMA denture base resins (Population) as compared with untreated or unconditioned surfaces (Control)?” In vitro and clinical reports as well as reports on influence of laser treatments on bonding strength of liners to PMMA denture resins in comparison with untreated surfaces were included. Reports without any control group[s], without any application of laser[s] for PMMA denture bases that did not utilize PMMA denture bases, and not evaluate bond strength of PMMA denture base resins were excluded. An electronic search was conducted on PubMed, Scopus, and Web of Science. Meta-analyses were performed for calculating the standard mean difference (SMD) with a 95% confidence interval (95% CI). Results: Nine of the 12 included studies found that laser irradiation treatment produced significant surface texture alterations of the PMMA denture base and improved the adhesion between the PMMA denture base and soft lining. According to the meta-analysis, tensile bond strength showed an SMD of -2.49% (95% CI: -3.89 to -1.08; p = 0.0005), suggesting a statistically significant difference between the control and test groups (i.e., favoring laser-treated samples than untreated samples). Regarding shear bond strength scores, the outcomes showed an SMD of -2.24% (95% CI: -3.79 to -0.69; p = 0.005), suggesting a statistically significant difference between the control and test groups (i.e., favoring laser-treated samples than untreated samples). Conclusions: Despite the high heterogeneity among the included studies, it can be concluded that laser treatment might improve the bonding strengths of liners to PMMA denture base resins as compared with untreated surfaces. To validate the aforementioned conclusions, further verification is required through the implementation of well-designed randomized controlled trials with large sample sizes.", "domain": "chemistry", "round": 3} +{"url": "https://lifetein.com/antibody_services.html", "date": "2024-03-04T02:35:26Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707947476409.38/warc/CC-MAIN-20240304002142-20240304032142-00810.warc.gz", "language_score": 0.9016691446304321, "token_count": 1346, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__4925253", "lang": "en", "text": "Please click here to get a quote for Antibody Service now!\nLifeTein provides a complete portfolio of antibody services including free peptide antigen design, peptide synthesis, and polyclonal and monoclonal antibody production, development, and purification services. As a leading provider of superior custom antibody development services, LifeTein promotes the understanding of life one protein at a time and offers a wide range of industry-leading platforms and services. LifeTein can customize a discovery and development path to fit your exact needs.\nLifeTein has developed the SIMBATM (SIngle Monoclonal B cell Antibody) technology based on single B cell retrieval to identify antigen-specific mAbs. The SIMBATM technology includes single cell RT-PCR with successional cloning and expression in vitro and requires relatively fewer cells. The SIMBATM technology is an attractive approach for retrieval of naive and antigen-experienced antibody repertoires generated in vivo and design of rationale structure-based vaccine.\nLifeTein's AdjuBoosterTM adjuvant was developed at our antibody campus core facility. It was proven to increase the immune response in a shorter time than competing products. Our facility uses this innovative new system to generate high-affinity custom antibodies. LifeTein scientists will work with you to generate custom antibodies for your research and development programs.\nFeatured Service: 🐇 Peptide Affinity Column Purified Polyclonal Antibody Service\nWe provide the following services:\n1. Free Peptide Antigen Design: Stronger antigenicity for the chosen domain.\n2. Custom Polyclonal Antibody Services: Peptide affinity column purified antibodies for less background (Choice of Rabbits🐇, Guinea Pigs🐹, Goats🐐,Llama🦙, Rats🐀, or Mice🐁).\n3. Custom Mice Monoclonal Antibody Services (Mice 🐁): Guaranteed two positive clones (Mice🐁 Only).\n4. Custom Rabbit🐇, Mouse🐇, or Llama 🦙 Monoclonal Antibody Services (SIMBATM: Single B cell based antibody technology).\nGet a quote or order now. We will process your order immediately. Please CLICK HERE for the quotation form.\nPaul F Gillespie, Richard R.Rustandi， et al. Quantitation of Coxsackievirus A21 Viral Proteins in Mixtures of Empty and Full Capsids using Capillary Western Human Gene Therapy; Available online Published Online:11 Dec 2022, https://doi.org/10.1089/hum.2022.147\nLifeTein generated antibodies for Vaccine Analytical Research Development and Vaccine Process Development Merck & Co., Inc., Kenilworth, NJ, USA. The rabbit polyclonal antibodies were generated against the Coxsackievirus A21 (CVA21) capsid proteins: VP1, VP2, VP3, and VP4. All animal work and sera collection were performed at Lifetein, LLC. The sera were affinity-purified by its corresponding peptides.\nRichard R.Rustandi， et al. Characterization of gH/gL/pUL128-131 pentameric complex, gH/gL/gO trimeric complex, gB and gM/gN glycoproteins in a human cytomegalovirus using automated capillary western blots; Vaccine; Available online 3 July 2021, https://doi.org/10.1016/j.vaccine.2021.06.033\nLifeTein generated Anti-gM and anti-gN antibodies for Vaccine Analytical Research Development and Vaccine Process Development Merck & Co., Inc., Kenilworth, NJ, USA. The rabbit polyclonal anti-gM and anti-gN antibodies were elicited by vaccinating animals with synthesized peptide sequences of gM (1-13aa and 345-372aa) and gN (61-101aa). Animal immunization and sera collection were performed at Lifetein, LLC (Hillsborough, NJ, USA). The sera were affinity-purified by its corresponding peptides.\nLifeTein helped synthesized a series of phosphorylated peptides. Then the peptides were used for phospho-specific p-METTL3 (S43) antibody productions. Sun et al. demonstrate that activation of the ERK pathway promotes m6A methylation by phosphorylation of METTL3 and WTAP.\nLifeTein made the affinity-purified rabbit polyclonal anti-SclA antibody. The purified streptococcal collagen-like protein A (SclA) antibodies demonstrated that a mutation in Group A Streptococcus carrier strains increase adherence and decrease virulence.\nLifeTein helped designed and synthesized a series of phosphorylated peptides. Then the peptides were used for phospho-specific antibody productions. The phospo-specific antibodies by LifeTein were confirmed to react with the epidermal growth factor receptor (EGFR). The Hung's lab showed that AGO2-Y393 phosphorylation mediates EGFR-enhanced cell survival and invasiveness under hypoxia. These findings suggest that modulation of miRNA biogenesis is important for stress response in tumour cells.\n... The following peptides were chemically synthesized for antibody production in mice (Lifetein Conc.), Elisa verification (LifeteinConc.) and peptide competition assay in immunohistochemistry (IHC)... Supplementary information\nCustom peptide antibodies were provided by LifeTein to study SKPO-1. The SKPO-1 peroxidase domain peptide was synthesized by LifeTein. The polyclonal antibodies were raised in rabbits and then affinity purified to accomplish high specifications and concentrations. The antibodies were successfully used to localize the SKPO-1 protein in hypodermis. It was found that the peroxidase SKPO-1 contributes to the host immune response during infection.\n... With respect to having a pAb raised for IHC, I designed a synthetic SKPO-1 peroxidase domain peptide to be chemically synthesized and have a pAb raised in rabbits against said peptide by Lifetein®. This endeavor was successful and is covered in Chapter 3...", "domain": "chemistry", "round": 3} +{"url": "http://contaminatednation.blogspot.com/2011/07/ancient-benzene-spill-threatens-vapor.html", "date": "2018-05-25T05:17:39Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-22/segments/1526794867041.69/warc/CC-MAIN-20180525043910-20180525063910-00018.warc.gz", "language_score": 0.9702404737472534, "token_count": 261, "dump": "CC-MAIN-2018-22", "global_id": "webtext-fineweb__CC-MAIN-2018-22__0__117642233", "lang": "en", "text": "By Duane Craig\n|Wood River Refinery in Roxana, Illinois|\nVapor Intrusion the cause?\nAccording to a report in The Telegraph, residents there have been warned not to sleep in their basements after samplings from below the slabs of some homes showed “elevated levels of hydrocarbons and lower explosive limits.” A couple of families decided to move from their homes and are being put up in local hotels courtesy of Shell Oil. Shell is also paying for all the monitoring costs that have been going on since the spill. Elevated levels of benzene were first discovered by the monitoring activities in 2005. Shell suggested the elevated levels could have been the result of the chemical making its way into the water table.\nNearby Hartford had a more serious yet similar problem years ago when a plume of gasoline rose and fell with the groundwater. Fumes collected in basements when the water table rose and some homes would spontaneously combust.\nIn a related story, KMOV TV 4 in St. Louis reported the widower of a schoolteacher from Roxana, who died of leukemia in 2008, has sued Shell Oil and BP Products North America for causing the woman’s cancer and death. The woman worked at a school nearby the refinery.", "domain": "chemistry", "round": 3} +{"url": "https://frontiersin.figshare.com/articles/dataset/Table1_A_Comprehensive_Evaluation_of_Sdox_a_Promising_H2S-Releasing_Doxorubicin_for_the_Treatment_of_Chemoresistant_Tumors_xls/19315151/1", "date": "2023-06-05T07:02:24Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-23/segments/1685224651325.38/warc/CC-MAIN-20230605053432-20230605083432-00135.warc.gz", "language_score": 0.8876869082450867, "token_count": 391, "dump": "CC-MAIN-2023-23", "global_id": "webtext-fineweb__CC-MAIN-2023-23__0__90027633", "lang": "en", "text": "Table1_A Comprehensive Evaluation of Sdox, a Promising H2S-Releasing Doxorubicin for the Treatment of Chemoresistant Tumors.xls\nSdox is a hydrogen sulfide (H2S)-releasing doxorubicin effective in P-glycoprotein-overexpressing/doxorubicin-resistant tumor models and not cytotoxic, as the parental drug, in H9c2 cardiomyocytes. The aim of this study was the assessment of Sdox drug-like features and its absorption, distribution, metabolism, and excretion (ADME)/toxicity properties, by a multi- and transdisciplinary in silico, in vitro, and in vivo approach. Doxorubicin was used as the reference compound. The in silico profiling suggested that Sdox possesses higher lipophilicity and lower solubility compared to doxorubicin, and the off-targets prediction revealed relevant differences between Dox and Sdox towards several cancer targets, suggesting different toxicological profiles. In vitro data showed that Sdox is a substrate with lower affinity for P-glycoprotein, less hepatotoxic, and causes less oxidative damage than doxorubicin. Both anthracyclines inhibited CYP3A4, but not hERG currents. Unlike doxorubicin, the percentage of zebrafish live embryos at 72 hpf was not affected by Sdox treatment. In conclusion, these findings demonstrate that Sdox displays a more favorable drug-like ADME/toxicity profile than doxorubicin, different selectivity towards cancer targets, along with a greater preclinical efficacy in resistant tumors. Therefore, Sdox represents a prototype of innovative anthracyclines, worthy of further investigations in clinical settings.", "domain": "chemistry", "round": 3} +{"url": "http://www.programmaster.org/PM/PM.nsf/ApprovedAbstracts/ACD4E6CDC7C5E15F8525814D004EDEDB?OpenDocument", "date": "2018-07-21T05:50:09Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-30/segments/1531676592387.80/warc/CC-MAIN-20180721051500-20180721071500-00391.warc.gz", "language_score": 0.8340370655059814, "token_count": 316, "dump": "CC-MAIN-2018-30", "global_id": "webtext-fineweb__CC-MAIN-2018-30__0__136907848", "lang": "en", "text": "|About this Abstract\n||2018 TMS Annual Meeting & Exhibition\n||Environmentally Assisted Cracking: Theory and Practice\n||Fundamental Mechanisms of Preventing Stress Corrosion Cracking of Austenitic Alloys by Laser Shock Peening\n||Bai Cui, Xueliang Yan, Fei Wang, Chenfei Zhang, Yongfeng Lu, Michael Nastasi\n|On-Site Speaker (Planned)\nStress corrosion cracking (SCC) is a significant problem for austenitic alloys in hot water corrosive environments, which limits their lifetime in petroleum, chemical, and nuclear industries. Laser shock peening (LSP) is a new approach that can effectively prevent SCC of austenitic alloys, but the fundamental mechanisms remain poorly understood. This study applies LSP to commercial 304 steels and oxide-dispersion-strengthened (ODS) 304 steels. In this process, laser-driven shock waves are generated which can penetrate to a depth of more than 1 mm from the surface, inducing significant compressive residual stresses. The shock waves can also result in microstructures of plastic deformation such as a high density of dislocations, stacking faults, and deformation twins in the affected region. This research will use experimental approaches to determine the processing-microstructure-property relationship of austenitic alloys in the LSP process, and understand the mechanisms that enable LSP to mitigate SCC of austenitic alloys.\n||Planned: Supplemental Proceedings volume", "domain": "chemistry", "round": 3} +{"url": "https://highwaydi.com/does-rv-antifreeze-go-bad/", "date": "2023-06-02T14:44:57Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-23/segments/1685224648695.4/warc/CC-MAIN-20230602140602-20230602170602-00746.warc.gz", "language_score": 0.9084489345550537, "token_count": 3091, "dump": "CC-MAIN-2023-23", "global_id": "webtext-fineweb__CC-MAIN-2023-23__0__283591537", "lang": "en", "text": "Have you ever wondered if that old bottle of RV antifreeze in your garage is still good to use? You’re not alone! In this informative article, we’re debunking the myth surrounding the question, Does RV Antifreeze Go Bad?\nWe’ll dive into the factors affecting its shelf life and provide you with the short answer you seek. So, buckle up, and let’s explore the truth about your trusty RV antifreeze, revealing best storage practices and alternative options.\nTable of Contents\nAntifreeze is crucial in protecting RV plumbing systems from freezing and damage. However, many RV owners are still determining the shelf life of antifreeze and whether it goes bad over time. This article will clarify this topic to help you properly maintain your RV.\nRV antifreeze is essential for preventing water in the plumbing system from freezing during cold temperatures.\nWithout it, pipes can burst and cause costly damage. Antifreeze aims to lower the freezing point of water so that it remains liquid even at low temperatures.\nContrary to popular belief, RV antifreeze does not necessarily go bad after one year. The shelf life of antifreeze can vary depending on factors such as temperature and exposure to air.\nIt is essential to properly store RV antifreeze in a cool, dry place to extend its shelf life.\nTesting the effectiveness of RV antifreeze before use is recommended to ensure it will adequately protect the plumbing system.\nThis can be done by placing a small amount of antifreeze in a freezer overnight and checking if it remains liquid.\nUnderstanding the shelf life of RV antifreeze can save time and money in the long run by avoiding potential plumbing issues.\nYou can enjoy your travels without any unexpected interruptions or costly repairs by properly caring for your RV’s plumbing system with regular maintenance and using high-quality products like effective antifreeze.\nWhat is RV antifreeze, and why is it important?\nDefinition of RV Antifreeze\nRV antifreeze is a specialized type of fluid used to protect the plumbing system of your recreational vehicle (RV) from freezing during cold weather.\nUnlike automotive antifreeze, it is non-toxic and safe for potable water systems. The primary function of RV antifreeze is to prevent water from freezing inside your RV’s plumbing system, which can cause pipes to burst and lead to costly repairs.\nDifferences between RV Antifreeze and Automotive Antifreeze\nAutomotive antifreeze contains toxic chemicals like ethylene glycol or propylene glycol, which are harmful if ingested.\nOn the other hand, RV antifreeze contains propylene glycol or ethanol as its main ingredient, making it safe for use in potable water systems.\nMoreover, automotive antifreeze has a higher boiling point than RV antifreeze since it needs to withstand elevated engine temperatures.\nIn contrast, RV antifreeze has a lower boiling point because it only needs to protect the plumbing system from freezing.\nKey Roles of RV Antifreeze in Protecting Your RV’s Plumbing System\nThe primary role of RV antifreeze is to prevent water from freezing inside your plumbing system during cold weather conditions.\nWhen water freezes, it expands and exerts pressure on the pipes’ walls, causing them to crack or burst open. This can lead to significant damage and expensive repairs.\nUsing RV antifreeze ensures your plumbing system remains protected even in extremely low temperatures. It also helps lubricate valves and seals within the plumbing system while preventing corrosion and rust buildup on metal surfaces.\nAnother crucial role of RV antifreeze is that it helps you properly winterize your recreational vehicle. Winterizing involves preparing your vehicle for storage during colder months when you’re not using it frequently.\nAdding adequate antifreeze into your plumbing system before storing it away for the winter can prevent any damage caused by freezing water.\nFactors affecting the shelf life of RV antifreeze\nChemical composition plays a crucial role in the shelf life of RV antifreeze. Different brands use different compounds to create antifreeze; some are more stable.\nThe more stable the compound, the longer the shelf life of the antifreeze. Ethanol-based antifreeze has a shorter shelf life compared to propylene glycol-based ones.\nPropylene glycol is known for its stability and can last for up to five years when stored correctly.\nStorage conditions also affect the shelf life of RV antifreeze. Exposure to sunlight or extreme temperatures can cause the chemical composition of the antifreeze to break down, reducing its effectiveness and shortening its lifespan.\nTherefore, storing RV antifreeze in a cool, dry place away from direct sunlight is essential to ensure maximum shelf life.\nExposure to contaminants is another factor affecting RV antifreeze’s shelf life. Water or dirt can reduce RV antifreeze’s effectiveness and freezing point.\nTherefore, it’s essential to keep containers sealed tightly when not in use and avoid exposing them to contaminants that may compromise their quality.\nSigns of expired or degraded RV antifreeze\nChanges in Color and Consistency\nOne of the most obvious signs that RV antifreeze has expired or degraded is a change in its color and consistency.\nFresh RV antifreeze typically has a bright pink color, but over time, it can start to fade and become cloudy. If your RV antifreeze has changed from its original color, it may be time to replace it.\nAnother thing to look out for is changes in the consistency of the fluid. Fresh RV antifreeze should have a smooth texture, but if it starts to become thick or clumpy, this could be another sign that it’s no longer effective.\nUsing expired or degraded RV antifreeze can cause damage to your RV pipes and water lines, leading to costly repairs down the line.\nUnusual odors from your RV antifreeze can also indicate that it has expired or degraded. In some cases, bacterial growth can occur within the fluid, causing a foul smell. This can happen when the fluid is exposed to air or moisture for extended periods.\nIf you notice an unusual odor coming from your RV antifreeze, don’t ignore it. Bacteria can cause damage to your pipes and valves if left unchecked.\nTherefore, addressing this issue as soon as possible is essential by dumping out the old fluid and replacing it with fresh antifreeze.\nPresence of Sediment or Particles\nSediment or particles in your RV antifreeze may also indicate expired or degraded. Over time, sediment can build up within the fluid due to exposure to air and moisture.\nThis sediment can clog up your faucets and valves if not addressed promptly.\nSuppose you notice sediment or particles in your RV antifreeze. Drain and flush out your pipes immediately before refilling them with fresh fluid.\nFailure to do so could damage your pipes and water lines, which can be costly.\nBest practices for storing and using RV antifreeze\nProper storage conditions for RV antifreeze\nRV antifreeze is essential for winterizing recreational vehicles, travel trailers, campers, and other similar vehicles.\nStoring the RV antifreeze properly is vital to ensure it remains effective during winterization. The ideal storage temperature for RV antifreeze is between 40°F and 70°F.\nStoring the antifreeze at a temperature higher than this range can cause it to break down and lose effectiveness.\nStoring RV antifreeze in a dry location away from direct sunlight is also essential. Exposure to sunlight can cause the plastic containers of the antifreeze to degrade and weaken, leading to leaks or spills.\nIn addition, storing RV antifreeze near heat sources such as radiators or furnaces can cause it to evaporate quickly, reducing its effectiveness.\nChecking expiration dates and manufacturing codes\nBefore using RV antifreeze for winterization, it is essential to check its expiration date and manufacturing code.\nExpired or outdated RV antifreeze may not provide adequate protection against freezing temperatures. In addition, it could damage the plumbing systems of your recreational vehicle.\nThe manufacturing code on the container of RV antifreeze provides information about when it was produced.\nThis information can help you determine whether the product has been stored correctly before purchase.\nIf you find any signs of damage or leakage in the container of RV antifreeze, do not use it as it may have been contaminated.\nImportance of regular RV maintenance\nRegular maintenance of your recreational vehicle’s plumbing system ensures that your RV antifreeze works as intended during winterization.\nNeglecting regular maintenance can lead to clogs or blockages in your plumbing system that prevent the proper distribution of the antifreeze throughout your vehicle’s pipes.\nIt would be best to take care of your recreational vehicle by regularly checking all its components, including water heaters, faucets, and waste tanks.\nIt would help if you also inspected your RV’s pipes and hoses for any wear or damage that could lead to leaks or bursts during winterization.\nUsing RV antifreeze designed explicitly for winterization purposes\nIt is essential to use RV antifreeze designed explicitly for winterization as it provides better protection than regular antifreeze used in vehicles.\nIn addition, RV antifreeze is formulated with propylene glycol, which is less toxic than ethylene glycol in regular antifreeze.\nPropylene glycol-based RV antifreeze is safe for use in plumbing systems. It does not harm the environment.\nIt can also be safely disposed of after use without causing harm to the environment.\nUsing an air compressor to blow out the plumbing system\nFor those who prefer not to use RV antifreeze, using an air compressor to blow out the plumbing systems can also be an effective method for winterizing most recreational vehicles, travel trailers, campers, and similar vehicles.\nHowever, it is vital to have a professional mechanic or technician perform this task to ensure that it is done safely and correctly.\nAlternatives to traditional RV antifreeze\nNon-toxic, eco-friendly antifreeze options are becoming increasingly popular among RV owners.\nThese alternatives to traditional RV antifreeze offer a range of benefits, making them a more attractive option for those looking to winterize their vehicles.\nThis section will explore some of the non-toxic antifreeze products available and discuss the advantages of switching to these alternatives.\nPropylene glycol RV antifreeze is one of the most well-known non-toxic options on the market. It’s safe for use in potable water systems.\nIn addition, it is often used in food processing facilities due to its low toxicity. Propylene glycol-based automotive coolant is another option to be an alternative to traditional RV antifreeze.\nThis coolant is readily available at auto parts stores and can be easily mixed with water before use.\nFresh antifreeze and marine antifreeze are two other non-toxic options worth considering. Fresh antifreeze is typically made from propylene glycol or ethanol and can be found at most hardware stores.\nOn the other hand, Marine antifreeze is explicitly designed for boats but can also be used in RVs. It’s typically made from propylene glycol or ethanol and contains additives that help protect against corrosion.\nSwitching to non-toxic antifreeze products offers several benefits over traditional toxic options.\nFor one, it reduces your environmental impact by eliminating harmful chemicals from entering the ecosystem when you flush your RV’s plumbing system in the springtime.\nNon-toxic options are also safer for pets and wildlife that may come into contact with spilled or leaked toxic antifreeze.\nAnother advantage of non-toxic alternatives is that they’re easier to dispose of than toxic ones.\nTraditional RV antifreeze must be disposed of as hazardous waste, which can be costly and time-consuming. Non-toxic alternatives can be safely disposed of down household drains or in compost piles.\nRecap the factors affecting RV antifreeze shelf life, the importance of proper storage and usage, and encourage readers to make informed decisions about their RV antifreeze.\nIn conclusion, it is essential to understand the factors affecting RV antifreeze’s shelf life. Chemical composition, storage conditions, and exposure to contaminants can all impact the quality and effectiveness of this product.\nProperly storing and using your RV antifreeze can reduce the risk of freezing pipes, damage to your heater or compressor tank, and costly repairs.\nAlways check expiration dates and manufacturing codes before using any RV antifreeze product. Notice changes in color or consistency, unusual odors, sediment, or particles in your bottle or tank. It may be time to replace your RV antifreeze.\nRemember that regular maintenance is vital when protecting your RV’s plumbing system during winter months.\nAlso, consider switching to non-toxic, eco-friendly options if you are concerned about the environmental impact of traditional RV antifreeze products.\nBy making informed decisions about your RV antifreeze usage and storage practices, you can ensure a longer shelf life for this essential winterizing tool.\nThank you for taking the time to read this article on does rv antifreeze go bad. We hope that we have answered any questions you may have regarding this topic.\nHow long can RV antifreeze be stored?\nRV antifreeze can typically be stored for up to five years, provided it’s kept in a cool, dry place with a stable temperature.\nDoes RV antifreeze deteriorate?\nRV antifreeze doesn’t necessarily deteriorate, but over time, and under extreme temperature conditions, it may lose its effectiveness.\nHow long can you leave an RV winterized?\nYou can leave an RV winterized for as long as needed, usually up to six months is common, but it’s crucial to de-winterize before using the plumbing system again.\nDoes marine antifreeze expire?\nLike RV antifreeze, marine antifreeze doesn’t have a set expiry date but its effectiveness may reduce after five years under less than ideal storage conditions.", "domain": "chemistry", "round": 3} +{"url": "https://www.ptglab.com/products/REDD1-Antibody-82650-1-RR.htm", "date": "2024-04-19T20:45:32Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712296817455.17/warc/CC-MAIN-20240419203449-20240419233449-00387.warc.gz", "language_score": 0.7361599206924438, "token_count": 780, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__66167851", "lang": "en", "text": "REDD1 Recombinant antibody\nREDD1 Recombinant Antibody for WB, ELISA\nHost / Isotype\nRabbit / IgG\nCat no : 82650-1-RR\n|Positive WB detected in\n|A549 cells, Cobalt Chloride treated HeLa cells, K-562 cells\n|Western Blot (WB)\n|WB : 1:2000-1:14000\n|It is recommended that this reagent should be titrated in each testing system to obtain optimal results.\n|Sample-dependent, Check data in validation data gallery.\n82650-1-RR targets REDD1 in WB, ELISA applications and shows reactivity with Human samples.\n|Host / Isotype\n|Rabbit / IgG\n|REDD1 fusion protein Ag0965\n|DNA-damage-inducible transcript 4\n|Calculated Molecular Weight\n|Observed Molecular Weight\n|GenBank Accession Number\n|Gene ID (NCBI)\n|Protein A purification\n|PBS with 0.02% sodium azide and 50% glycerol pH 7.3.\n|Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.\nREDD1, also named as RTP801 and DDIT4, belongs to the DDIT4 family. REDD1 promotes neuronal cell death. It is a novel transcriptional target of p53 implicated ROS in the p53-dependent DNA damage response. REDD1 controlled cell growth under energy stress, as an essential regulator of TOR activity through the TSC1/2 complex. REDD-1 expression has also been linked to apoptosis, Aβ toxicity and the pathogenesis of ischemic diseases. As an HIF-1-responsive gene, REDD-1 exhibits strong hypoxia-dependent upregulation in ischemic cells of neuronal origin[PMID: 19996311]. In response to stress due to DNA damage and glucocorticoid treatment, REDD-1 is upregulated at the transcriptional level[PMID: 21733849]. REDD-1 negatively regulates the mammalian target of Rapamycin, a serine/threonine kinase often referred to as mTOR[PMID: 22951983]. It is crucial in the coupling of extra- and intracellular cues to mTOR regulation. The absence of REDD-1 is associated with the development of retinopathy, a major cause of blindness[PMID: 22304497]. REDD1 is a new host defense factor, and chemical activation of REDD1 expression represents a potent antiviral intervention strategy[PMID: 21909097]. The calculated molecular weight of REDD1 is 25 kDa. Because of multiple lysines in the proteins, REDD1 offen migrates around 35 kDa on Western blot[PMID: 19221489].", "domain": "chemistry", "round": 3} +{"url": "http://www.mdpi.com/1420-3049/17/2/1419", "date": "2018-01-18T22:32:16Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-05/segments/1516084887621.26/warc/CC-MAIN-20180118210638-20180118230638-00460.warc.gz", "language_score": 0.7787270545959473, "token_count": 419, "dump": "CC-MAIN-2018-05", "global_id": "webtext-fineweb__CC-MAIN-2018-05__0__226111719", "lang": "en", "text": "A New Iridoid Glycoside from the Roots of Dipsacus asper\nAbstractA new iridoid glycoside, named loganic acid ethyl ester (1), together with five known compounds: chlorogenic acid (2), caffeic acid (3), loganin (4), cantleyoside (5) and syringaresinol-4′,4′′-O-bis-β-D-glucoside (6) were isolated from the roots of Dipsacus asper. The structure of compound 1 was elucidated on the basis of detailed spectroscopic analyses. Lignan is isolated from Dipsacaceae species for the first time. Compounds 1, 4 and 5 had moderate neuroprotective effects against the Aβ25–35 induced cell death in PC12 cells.\nScifeed alert for new publicationsNever miss any articles matching your research from any publisher\n- Get alerts for new papers matching your research\n- Find out the new papers from selected authors\n- Updated daily for 49'000+ journals and 6000+ publishers\n- Define your Scifeed now\nJi, D.; Zhang, C.; Li, J.; Yang, H.; Shen, J.; Yang, Z. A New Iridoid Glycoside from the Roots of Dipsacus asper. Molecules 2012, 17, 1419-1424.\nJi D, Zhang C, Li J, Yang H, Shen J, Yang Z. A New Iridoid Glycoside from the Roots of Dipsacus asper. Molecules. 2012; 17(2):1419-1424.Chicago/Turabian Style\nJi, De; Zhang, Chunfeng; Li, Jingzhi; Yang, Haowei; Shen, Jingyang; Yang, Zhonglin. 2012. \"A New Iridoid Glycoside from the Roots of Dipsacus asper.\" Molecules 17, no. 2: 1419-1424.", "domain": "chemistry", "round": 3} +{"url": "https://research.com/u/victor-w-rodwell", "date": "2023-04-01T23:29:06Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-14/segments/1679296950363.89/warc/CC-MAIN-20230401221921-20230402011921-00644.warc.gz", "language_score": 0.866071343421936, "token_count": 1141, "dump": "CC-MAIN-2023-14", "global_id": "webtext-fineweb__CC-MAIN-2023-14__0__10745202", "lang": "en", "text": "His primary areas of study are Biochemistry, Reductase, Hydroxymethylglutaryl-CoA reductase, Mevalonic acid and Enzyme. He regularly ties together related areas like Molecular biology in his Biochemistry studies. His Reductase research integrates issues from Oxidoreductase and Endocrinology.\nHis research in Hydroxymethylglutaryl-CoA reductase intersects with topics in NAD+ kinase, Stereochemistry and Mevalonate pathway. His Mevalonic acid research is multidisciplinary, incorporating elements of Microsome and Chromatography, Extraction. His Enzyme research incorporates themes from Hamster and Escherichia coli.\nHis primary scientific interests are in Biochemistry, Reductase, Enzyme, Stereochemistry and Coenzyme A. His work in Biochemistry is not limited to one particular discipline; it also encompasses Molecular biology. As a part of the same scientific family, he mostly works in the field of Reductase, focusing on Phosphorylation and, on occasion, Kinase.\nThe Enzyme study combines topics in areas such as Mutant, Hamster and Metabolism. The various areas that Victor W. Rodwell examines in his Coenzyme A study include Lyase and Biosynthesis. The concepts of his HMG-CoA reductase study are interwoven with issues in Endocrinology and Cholesterol.\nBiochemistry, Reductase, HMG-CoA reductase, Stereochemistry and Mevalonate pathway are his primary areas of study. His study in Enzyme, Enterococcus faecalis and Pseudomonas mevalonii are all subfields of Biochemistry. His is doing research in Hydroxymethylglutaryl-CoA reductase, Coenzyme A and HMG-Coenzyme A, both of which are found in Reductase.\nIn his work, Hemiacetal is strongly intertwined with NAD+ kinase, which is a subfield of HMG-CoA reductase. His biological study deals with issues like Active site, which deal with fields such as Ligand, Oxidoreductase and Mutant. Victor W. Rodwell interconnects Mevalonic acid and Thiolase in the investigation of issues within Mevalonate pathway.\nThis overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.\nRegulation of HMG-CoA Reductase\nVictor W. Rodwell;Jeffrey L. Nordstrom;Jonathan J. Mitschelen.\nAdvances in lipid research (1976)\nMicro assay for 3-hdyroxy-3-methylglutaryl-CoA reductase in rat liver and in L-cell fibroblasts\nDavid J. Shapiro;Jeffrey L. Nordstrom;Jonathan J. Mitschelen;Victor W. Rodwell.\nBiochimica et Biophysica Acta (1974)\nRegulation of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase and cholesterol synthesis.\nDavid J. Shapiro;Victor W. Rodwell.\nJournal of Biological Chemistry (1971)\nThe 3-hydroxy-3-methylglutaryl coenzyme-A (HMG-CoA) reductases.\nJon A Friesen;Victor W Rodwell.\nGenome Biology (2004)\nInterconversion of active and inactive forms of rat liver hydroxymethylglutaryl-CoA reductase.\nNordstrom Jl;Rodwell Vw;Mitschelen Jj.\nJournal of Biological Chemistry (1977)\nDiurnal variation and cholesterol regulation of hepatic HMG-CoA reductase activity☆\nDavid J. Shapiro;Victor W. Rodwell.\nBiochemical and Biophysical Research Communications (1969)\nRegulation of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase. Developmental pattern.\nDonald J. McNamara;Forrest W. Quackenbush;Victor W. Rodwell.\nJournal of Biological Chemistry (1972)\nThin-layer chromatographic assay for HMG-CoA reductase and mevalonic acid\nDavid J. Shapiro;Richard L. Imblum;Victor W. Rodwell.\nAnalytical Biochemistry (1969)\nThe microestimation, distribution, and biosynthesis of 2, 3-diphosphoglyceric acid.\nJack C. Towne;Victor W. Rodwell;Santiago Grisolia.\nJournal of Biological Chemistry (1957)\nEnterococcus faecalis Acetoacetyl-Coenzyme A Thiolase/3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase, a Dual-Function Protein of Isopentenyl Diphosphate Biosynthesis\nMatija Hedl;Autumn Sutherlin;E. Imogen Wilding;Marie Mazzulla.\nJournal of Bacteriology (2002)\nIf you think any of the details on this page are incorrect, let us know.\nWe appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:", "domain": "chemistry", "round": 3} +{"url": "https://www.genetex.com/Product/Detail/VAV2-antibody/GTX16135", "date": "2019-03-19T09:37:19Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-13/segments/1552912201953.19/warc/CC-MAIN-20190319093341-20190319115341-00053.warc.gz", "language_score": 0.8508609533309937, "token_count": 363, "dump": "CC-MAIN-2019-13", "global_id": "webtext-fineweb__CC-MAIN-2019-13__0__184739376", "lang": "en", "text": "Preservative: 0.08% Sodium Azide; Constituents: PBS\nStore as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.\nHis tagged fusion protein, corresponding to amino acids 578-878 of Human VAV2.\nThis antibody is provided as a 0.2 μm sterile filtered solution.\nFor laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.\nVav Guanine Nucleotide Exchange Factor 2,Vav-2,Vav2\nVAV2 is a ubiquitously expressed structural homolog of the VAV protooncogene that is expressed preferentially in hematopoetic cells. Both proteins are comprised of a Dbl homology (DH) domain with guanosine nucleotide exchange (GEF) activity exclusively directed towards Rho/Rac GTPases, a pleckstrin homology (PH) domain, a calponin-homology (CH) region, an acidic domain (AD) a zinc finger butterfly motif, two SH3 regions and one SH2 domain. GEF activity of RhoA family G proteins is induced by tyrosine phosphorylation in wild type VAV2, and is constitutively activated in N terminus deleted oncogene forms. Constitutive expression of a VAV2 oncoprotein may result in morphological alterations including highly enlarged cells in which karyokinesis and cytokinesis frequently are uncoupled.", "domain": "chemistry", "round": 3} +{"url": "https://www.gardenofficial.com/en/product/skin-care-cream/", "date": "2021-05-15T20:29:36Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-21/segments/1620243991378.52/warc/CC-MAIN-20210515192444-20210515222444-00458.warc.gz", "language_score": 0.7711285948753357, "token_count": 425, "dump": "CC-MAIN-2021-21", "global_id": "webtext-fineweb__CC-MAIN-2021-21__0__222058415", "lang": "en", "text": "Contains 5% Panthenol, 5% Urea and it is enhanced with Olive Oil. The combined action of these ingredients, enhances the restructure and the facial of the sore and sensitive skin. It is indicated in case that the skin is sore, dehydrated and dry, after sun or mild burns, exposure at intense weather conditions like cold, wind, etc. Furthermore when the skin is weather beaten with cracks and mild injuries from various activities or sore from the use of detergents. GARDEN SKIN CARE CREAM contains neutral pH, it is suitable for all skin types and leaves no traces of oiliness. It is free of parabens, color and fragrance, that can cause allergies.\nDERMATOLOGICALLY TESTED. PARABENS FREE, FRAGRANCE FREE, COLORANTS FREE\nINGREDIENTS: AQUA (WATER), UREA, PANTHENOL, GLYCERYL STEARATE, PARAFFINUM LIQUIDUM (MINERAL OIL), GLYCERIN, CETYL ALCOHOL, DIMETHICONE, PROPYLENE GLYCOL, OLEA EUROPAEA (OLIVE) FRUIT OIL*, ALLANTOIN, BISABOLOL, GLYCYRRHETINIC ACID, TOCOPHERYL ACETATE, SODIUM CARBOXYMETHYL BETAGLUCAN, PEG-100 STEARATE, CETEARYL ETHYLHEXANOATE, ISOPROPYL MYRISTATE, ACRYLAMIDE/SODIUM ACRYLATE COPOLYMER, TRIDECETH-6, TRIETHANOLAMINE, CARBOMER, DISODIUM EDTA, BENZOPHENONE-4, PHENOXYETHANOL, ETHYLHEXYLGLYCERIN, CHLORPHENESIN\nApply the cream on the affected area as many times as it is necessary", "domain": "chemistry", "round": 3} +{"url": "http://jtsb.ijournals.cn/jtsb_cn/article/abstract/4441", "date": "2022-05-20T09:50:12Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-21/segments/1652662531779.10/warc/CC-MAIN-20220520093441-20220520123441-00124.warc.gz", "language_score": 0.7940639853477478, "token_count": 1211, "dump": "CC-MAIN-2022-21", "global_id": "webtext-fineweb__CC-MAIN-2022-21__0__202433589", "lang": "en", "text": "为了解乙烯诱导水仙（Narcissus tazetta var.chinensis）成花的生理和分子机制，利用代谢组和转录组测序技术，筛选乙烯诱导水仙成花的差异表达代谢物和基因。结果表明，乙烯处理的侧芽检测到12个差异表达代谢物（DEM），包括7个上调，5个下调，其中，（±）7-表茉莉酸、多巴胺、亚精胺可能与乙烯诱导水仙成花正相关，而吲哚及其衍生物呈负相关。转录组共获得1 021个差异表达基因（DEG），包括615个上调，406个下调，在DEG中鉴定筛选了45个与乙烯信号传导和开花相关的差异表达基因。乙烯诱导水仙成花启动可能先激活水仙鳞茎内源植物激素（尤其乙烯）信号通路的变化，与开花促进基因FPF1和MADS15的上调表达密切相关。9个基因的qRT-PCR结果验证了RNA-Seq的正确性。这些差异表达的代谢物和基因在水仙成花启动过程中可能具有重要作用。\nIn order to understand the mechanism of the narcissus (Narcissus tazetta var. chinensis) floral induction, the differentially expressed metabolites and genes were screened from the outermost buds treated with exogenous ethylene by using metabolome and transcriptome sequencing techniques. The results showed that 12 differentially expressed metabolites (DEMs) were detected, including 7 up-regulated and 5 down-regulated DEMs. Among them, (±) 7-epigenJasmonic acid, dopamine and spermidine might be positively correlated with narcissus floral induction, while indole and its derivatives were negatively correlated. A total of 1 021 differentially expressed genes (DEGs) were identified in the transcriptome, including 615 up-regulated and 406 down-regulated DEGs. Forty-five differentially expressed genes related to ethylene signal transduction and flowering were identified in the DEGs. The changes of endogenous plant hormone (especially ethylene) signaling pathway in narcissus bulbs were activated firstly by exogenous ethylene, and the floral induction of narcissus via exogenous ethylene was closely related to the up-regulated expression of FPF1 and MADS15. Nine genes correlated with flowering were verified by qRT-PCR analysis and the expression profiles were consistent with the RNA-Seq results. Therefore, these DEMs and DEGs might have vital function on the narcissus floral induction, which might play an important role in the floral formation of narcissus induced exogenous ethylene.", "domain": "chemistry", "round": 3} +{"url": "https://www.spectroscopyonline.com/view/simplify-your-icp-oes-analyses-while-optimizing-productivity-and-precision", "date": "2023-09-22T12:47:07Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233506399.24/warc/CC-MAIN-20230922102329-20230922132329-00538.warc.gz", "language_score": 0.8839284777641296, "token_count": 262, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__121318181", "lang": "en", "text": "*Live: Tuesday, June 8, 2021 at 11am EDT| 8am PDT| 4pm GMT|5pm CET* Don’t miss the opportunity to discover how key software and hardware technologies can help reduce turnaround time and improve your results. *On Demand Until June 8, 2022*\nRegister free: http://www.spectroscopyonline.com/spec_w/ICP\nBoth hardware and software impact everyday workflows in your ICP laboratory. Commercial testing labs utilize automation for quick turnaround times while delivering high levels of sample accuracy. In addition, certain applications, such as metallurgical, need to optimize for sample accuracy as metal purity can vary batch to batch. In both cases, intuitive software workflows deliver greater uptime for the laboratory. During this webinar, you will gain key insights to optimize lab efficiencies, focusing on applications demanding fast sample-to-sample time and high accuracy.\nKey Learning Objectives:\nTime and date: Wednesday, June 8, 2021 at 1pm EDT| 12pm CDT| 10am PDT\nOn demand available after airing until June 8, 2022.\nSponsor: Perkin Elmer", "domain": "chemistry", "round": 3} +{"url": "https://guestts.com/ammonium-lauryl-sulphate-prices-trends-forecasts-provided-by-procurement-resource/", "date": "2024-02-27T07:20:11Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707947474671.63/warc/CC-MAIN-20240227053544-20240227083544-00435.warc.gz", "language_score": 0.9024542570114136, "token_count": 1154, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__174919755", "lang": "en", "text": "In the Asian market, post-Covid reopening led to limited demand for Ammonium Lauryl Sulphate, while increased production capacities raised inventory levels. Lower feedstock prices and improved freight systems lowered costs, but prices remained consistently low. In Europe, economic crises affected consumer sentiment, causing minimal buying and cost pressures. Supply chain restoration lowered freight costs, resulting in mixed price trends. Similarly, in North America, reduced production costs and limited demand led to stagnant Ammonium Lauryl Sulphate prices, reflecting subdued market activity.\nRequest for Real-Time Ammonium Lauryl Sulphate Prices: https://www.procurementresource.com/resource-center/ammonium-lauryl-sulphate-price-trends/pricerequest\nAmmonium Lauryl Sulphate (ALS) is a surfactant commonly used in personal care and cleaning products. It serves as a foaming and cleansing agent due to its ability to reduce the surface tension of liquids, facilitating the removal of dirt and oils from surfaces. ALS is synthesized by combining lauryl alcohol with sulfuric acid, followed by neutralization with ammonia. While effective in producing lather and enhancing product performance, ALS has raised concerns for potential skin irritation and environmental impacts. It’s utilized in shampoos, body washes, and household cleaners, contributing to their cleaning and foaming properties.\nKey Details About the Ammonium Lauryl Sulphate Price Trend:\nProcurement Resource does an in-depth analysis of the price trend to bring forth the monthly, quarterly, half-yearly, and yearly information on the Ammonium Lauryl Sulphate in its latest pricing dashboard. The detailed assessment deeply explores the facts about the product, price change over the weeks, months, and years, key players, industrial uses, and drivers propelling the market and price trends.\nEach price record is linked to an easy-to-use graphing device dated back to 2014, which offers a series of functionalities; customization of price currencies and units and downloading of price information as Excel files that can be used offline.\nThe Ammonium Lauryl Sulphate Price chart, including India Ammonium Lauryl Sulphate price, USA Ammonium Lauryl Sulphate price, pricing database, and analysis can prove valuable for procurement managers, directors, and decision-makers to build up their strongly backed-up strategic insights to attain progress and profitability in the business.\nIndustrial Uses Impacting the Ammonium Lauryl Sulphate Price Trend:\nAmmonium Lauryl Sulphate (ALS) finds application in various industrial sectors. Primarily used as a surfactant and foaming agent, ALS is vital in producing personal care products like shampoos, body washes, and toothpaste due to its ability to create lather and effectively cleanse. It’s also employed in the formulation of detergents, cleaning agents, and industrial cleaners for its excellent emulsifying and degreasing properties. ALS contributes to the stability and effectiveness of these products, enhancing their cleaning and foaming capabilities. Its versatility in improving product performance makes it a crucial ingredient in the cosmetics, cleaning, and industrial sectors.\n- Galaxy Surfactants Limited\n- BASF SE\n- CAMEO Chemicals\n- Taiwan NJC Corporation\n- The Reliance Group\nNews and recent developments:\nThe Indian Surfactant Group (ISG) has expressed concerns about the potential negative impact of proposed antidumping and countervailing duties on saturated fatty alcohol, a crucial raw material in soap, detergent, and shampoo production. ISG’s convener, Manoj Jha, emphasized that these duties might create an inverted duty structure, making user industries less competitive. He warned that this could lead to downsizing operations, affecting employment and profitability. The ISG has urged the Union finance minister, Nirmala Sitharaman, to reconsider the implementation of these duties to prevent potential price hikes and economic repercussions in the soap and detergent industry.\nProcurement Resource offers in-depth research on product pricing and market insights for more than 500 chemicals, commodities, and utilities updated daily, weekly, monthly, and annually. It is a cost-effective, one-stop solution for all your market research requirements, irrespective of which part of the value chain you represent.\nWe have a team of highly experienced analysts who perform comprehensive research to deliver our clients the newest and most up-to-date market reports, cost models, price analysis, benchmarking, and category insights, which help in streamlining the procurement process for our clientele. Our team tracks the prices and production costs of a wide variety of goods and commodities, hence providing you with the latest and consistent data.\nTo get real-time facts and insights to help our customers, we work with a varied range of procurement teams across industries. At Procurement Resource, we support our clients, with up-to-date and pioneering practices in the industry, to understand procurement methods, supply chain, and industry trends, so that they can build strategies to achieve maximum growth.\nCompany Name: Procurement Resource\nContact Person: Jolie Alexa\nToll-Free Number: USA & Canada – Phone no: +1 307 363 1045 | UK – Phone no: +44 7537 132103 | Asia-Pacific (APAC) – Phone no: +91 1203185500\nAddress: 30 North Gould Street, Sheridan, WY 82801, USA", "domain": "chemistry", "round": 3} +{"url": "https://radiobtech.com/products/12v-24ah-lifepo4-battery-rechargeable-battery-rv-marine-solar-power-wheels-ups", "date": "2023-09-29T04:48:54Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233510481.79/warc/CC-MAIN-20230929022639-20230929052639-00541.warc.gz", "language_score": 0.6516919732093811, "token_count": 558, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__35009547", "lang": "en", "text": "Using the technology of lithium iron phosphate cell, superior safety, thousands of cycles, 100%DOD, under normal conditions.\n- Built-in automatic protection for over-charge, over discharge, over\n- current and over temperature.\n- Free of maintenance .\n- Internal cell balancing.\n- Lighter weight: About 40% ~50% of the weight of a comparable\n- lead acid battery.\n- Can be charged using most standard lead-acid charges (set).\n- Wider temperature range:-20℃~60℃.\n- Support for Series application expansion (up to 51.2V) and two in parallels.\nNominal Voltage 12.8V\nNominal Capacity email@example.com\nInternal Resistance ≤60mΩ\nCycle Life 2000 Cycles @ 0.2C Charging/Discharging ,Until 70% Capacity\nSelf Discharge ≤3.5% per month at 25℃\nMax.Charging Voltage 14.0~14.6V\nAt 0℃~45℃ temperature, charged to 14.6V at a constant current of 0.2C, and\nthen,changed continuously with constant voltage of 14.6V until the current was not\nmore than 0.02C\nCharging Current 12A\nMax.Charging Current 20A\nDischarging Current 12A\nMax. Continuous Current 20A\nMax.Pulse Current 40A(<3S）\nDischarging Cut-off Voltage 10.0\nCharge Temperature 0℃ to 45℃(32℉ to 113℉) @60±25% Relative Humidity\nDischarge Temperature -20℃ to 60℃(-4℉ to 140℉) @60±25% Relative Humidity\nStorage Temperature 0℃ to 45℃(32℉ to 113℉) @60±25% Relative Humidity\nWater Dust Resistance IP55\nCell & Format IFR32700 N60,4S4P\nWeight Approx. 2.7Kg\nBattery Datasheet - https://cdn.shopify.com/s/files/1/0563/6594/0934/files/RadioB_12v_24ah.pdf?v=1620416708", "domain": "chemistry", "round": 3} +{"url": "https://epjst.epj.org/articles/epjst/abs/2008/06/st158017/st158017.html", "date": "2021-09-26T18:35:05Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-39/segments/1631780057913.34/warc/CC-MAIN-20210926175051-20210926205051-00400.warc.gz", "language_score": 0.7241455912590027, "token_count": 297, "dump": "CC-MAIN-2021-39", "global_id": "webtext-fineweb__CC-MAIN-2021-39__0__211469246", "lang": "en", "text": "Reversible and irreversible martensitic transformations in Fe-Pd and Fe-Pd-Co alloys\nUniversidad Pública de Navarra (UPNA), Campus Arrosadia, 31006 Pamplona, Spain\n2 Institute of Magnetism, NAS of Ukraine, 36-B Vernadsky Str., Kiev, 03142, Ukraine\n3 Institut Laue Langevin (ILL), 6 rue Jules Horowitz, Grenoble, France\n4 Instituto de Ciencias de Materiales de Aragón (ICMA), CSIC-Universidad de Zaragoza, Zaragoza, 50009, Spain\nFerromagnetic Fe-Pd shape memory alloys (SMA) undergo a martensitic phase transformation during cooling from a parent FCC phase to a tetragonal FCT martensite. This transformation is thermoelastic and reversible giving rise to the shape memory effect. On further cooling an irreversible FCT to BCT transformation occurs that makes impossible the memory effect. Nevertheless, the transformation from reversible to irreversible phase has been not complete since a volume fraction of reversible phase in the alloy is retained even after cooling below the temperature of appearance of the irreversible phase. The addition of Co lowers the temperature of the reversible and irreversible phase transformations but also reduces the amount of transformed irreversible martensite after cooling to 10 K.\n© EDP Sciences, Springer-Verlag, 2008", "domain": "chemistry", "round": 3} +{"url": "https://store.biomedx.com/products/conductivity-test-meter/", "date": "2021-04-20T04:31:47Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-17/segments/1618039375537.73/warc/CC-MAIN-20210420025739-20210420055739-00407.warc.gz", "language_score": 0.8162851333618164, "token_count": 768, "dump": "CC-MAIN-2021-17", "global_id": "webtext-fineweb__CC-MAIN-2021-17__0__42192290", "lang": "en", "text": "Conductivity Test Meter\nThe ultimate conductivity pocket tester. Your lab-\nMeasure conductivity of urine, saliva, water, soil or other fluids with dual point calibration accuracy.\nThe perfect tool to begin thinking through zeta potential and conductivity relationships as it relates to cardiovascular and renal stress and overall health. There’s the zone you want to be in and the zone you don’t and you can’t know where you’re at unless you measure.\nDr. T.C. McDaniel built a radically successful cardio/renal practice around the use of this single tool.\nComes with case, 1.41 & 12.9 millisiemen calibration fluids, instructions, quik card, and net access to the Biomedx conductivity manual, charts, and tracking sheets.\nYou can determine water conductivity with as little as 0.12 mL of sample.\nApplications: The conductivity of rain water is a trusted guide to determining atmospheric purity. In agriculture, measuring the conductivity of soil allows farmers and agronomists to determine optimum fertilizer usage and check the ‘health’ of soil after salt water damage. Interested in effects of government geo-\nWhether fresh water testing (rain, rivers, lakes, hot springs); aquaria; soil testing for improved agriculture and analysis of salt water damage; analysis of surface cleanliness prior to coating; and improved paint adhesion; checking urine and saliva and learning more about the connections of conductivity to zeta potential and health, this meter makes conductivity testing simple, anywhere.\nFlat sensor technology realizes a reliable and direct measurement from just a drop of the sample.\nConductivity readings can be converted into Salt and TDS.\nIP67 waterproof and dustproof.\nTemperature compensation/Auto hold/Auto range change.\nMeasurement principle: 2 AC bipolar\nMinimum sample volume: 0.12 mL or more\nMeasurement range Conductivity: 0 to 199.99 mS/cm\nTDS: 0 to 9990 ppm\nDisplay range: 0 to 199 mS/cm (The display value flashes when out of the range)\nRange and Resolution:\n1) 0 to 199 μS/cm : 1 μS/cm\n2) 0.20 to 1.99 mS/cm : 0.01 mS/cm\n3) 2.0 to 19.9 mS/cm : 0.1 mS/cm\n4) 20 to 199 mS/cm : 1 mS/cm\nAccuracy (Repeatability in measurement of a standard solution after calibration): ±2%F.S.±1digit (for each range)\n±2% full scale (for each range)\n±2% full scale (0 to 19.99 mS/cm)\n±5% full scale (20 to 199.99 mS/cm)\nFunctions: Conductivity in siemen units & TDS in ppm • Auto range change • Temperature conversion (2%/°C fixed) • Auto hold • Automatic power off (15 minutes) • IP67 Water/Dust proof (no failure when immersed in water at a depth of 1 meter for 30 minutes, but the product can not be used underwater.)\nDisplay: Custom (monochrome) digital LCD\nOperating temperature/ humidity: 5 to 40°C, 85% or less in relative humidity (no condensation)\nPower: CR2032 batteries (x2)\nBattery life: Approximately 400 hours in continuous use\nMain Material: ABS epoxy\nDimensions /Mass: 164 mm × 29 mm × 20 mm (excluding projections) / Approx. 45 g (meter only, without batteries)", "domain": "chemistry", "round": 3} +{"url": "http://plaza.umin.ac.jp/JPS1927/jjp/issue/TOC96-72(3)/96-72-223.html", "date": "2018-01-19T01:46:07Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-05/segments/1516084887692.13/warc/CC-MAIN-20180119010338-20180119030338-00545.warc.gz", "language_score": 0.9072409272193909, "token_count": 462, "dump": "CC-MAIN-2018-05", "global_id": "webtext-fineweb__CC-MAIN-2018-05__0__9747779", "lang": "en", "text": "Niro Inaba, Masahiro Shibata, Sadayoshi Onodera, Masato Tanaka, Takao Suzuki, Noriko Kase and Tetuaki Yamaura\nPharmaceuticals Research Laboratories, Fujirebio Inc., 51, Komiya-cho, Hachioji, Tokyo 192, Japan\nAbstract: The peripheral capsaicin-sensitive afferent nerve has been reported to play an important role in gastroprotection and to release a calcitonin gene-related peptide (CGRP). We developed a new chemiluminescent enzyme immunoassay (CLEIA) for CGRP and measured capsaicin-induced CGRP release from the isolated and inverted rat stomach. The basal CGRP release from the stomach was 0.40+/-0.02 pg/mg wet weight in a 30-min incubation. Capsaicin (1 x 10-8 - 1 x 10-5 M) stimulated CGRP release in a concentration-dependent manner. In the stomach from rats with defunctionalization of afferent neurons, the levels of the basal and capsaicin-induced CGRP release were below the limit of detection. On the other hand, the capsaicin-induced CGRP release was not blocked by tetrodotoxin treatment. The gangliosympathectomy abolished the increase in the CGRP levels. However, the capsaicin-induced CGRP release was not affected by pretreatment with 6-hydroxydopamine, a neurotoxin that causes a complete degeneration of adrenergic nerve terminals. In conclusion, the CLEIA system may be useful for detecting the released CGRP and studying the activity of capsaicin-sensitive nerves, particulary the CGRP-containing nerves. Our results also confirmed that although the CGRP-containing nerve runs in the sympathetic nerve trunk, the activity of the nerve is not affected by adrenergic nerves, and the capsaicin-induced CGRP release may be attributable to the tetrodotoxin-resistant component.\nCalcitonin gene-related peptide, Capsaicin, Chemiluminescent enzyme immunoassay\n[Back to TOC]", "domain": "chemistry", "round": 3} +{"url": "http://www.idekerjadirumah.com/pharmaceutical-drugs/penicillins.html", "date": "2019-11-17T18:38:23Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-47/segments/1573496669225.56/warc/CC-MAIN-20191117165616-20191117193616-00538.warc.gz", "language_score": 0.8646646738052368, "token_count": 263, "dump": "CC-MAIN-2019-47", "global_id": "webtext-fineweb__CC-MAIN-2019-47__0__196365238", "lang": "en", "text": "|Prescription Drugs||Non-Prescription Drugs|\nPenicillins are antibiotics (medicines used to treat infections caused by microorganisms). There are several types of Penicillins, each used to treat different kinds of infections, such as skin infections, dental infections, ear infections, respiratory tract infections, urinary tract infections, gonorrhea, and other infections caused by bacteria. These drugs will not work for colds, flu, and other infections caused by viruses.\nExamples of Penicillins are Penicillin V (Beepen-VK, Pen-Vee K, V-cillin K, Veetids) and Amoxicillin (Amoxil, Polymox, Trimox, Wymox). Penicillins are sometimes combined with other ingredients called Beta-lactamase Inhibitors, which protect the penicillin from bacterial enzymes that may destroy it before it can do its work. The drug Augmentin, for example, contains a combination of Amoxicillin and a beta-lactamase Inhibitor, Clavulanic Acid.\nPenicillins are available only with a physician's prescription. They are sold in capsule, tablet (regular and chewable), liquid, and injectable forms.", "domain": "chemistry", "round": 3} +{"url": "http://www.gmforum.com/performance-brainstorming-tuning-96/maintenence-time-190379/page3/", "date": "2016-10-28T10:30:04Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2016-44/segments/1476988721606.94/warc/CC-MAIN-20161020183841-00070-ip-10-171-6-4.ec2.internal.warc.gz", "language_score": 0.8395673036575317, "token_count": 1067, "dump": "CC-MAIN-2016-44", "global_id": "webtext-fineweb__CC-MAIN-2016-44__0__65441591", "lang": "en", "text": "Originally Posted by Drifter420\nOriginally Posted by White Lightning\nwhy not suggest using synthetic? is this something i should be telling the service dept or mechanic?\ni haven't checked the color yet\nbut hopfully i'll look at her tomarrow or something.\nAs far as I've heard.. synthetic ATF is bad cause it slips too much and will then wear the tranny out more..\nIt'* not that'* it is more slippier that'* the problem here. It'* the fact the high mileage transmission has varnish buildup that when combined with a thinner fluid will cause the clutches to slip.\nFor more info on Amsoil'* Synthetic ATF Fluid keep reading:\nSynthetic Automatic Transmission Fluid\nImproves fuel efficiency, reduces transmission temperatures and increases transmission life. Provides unsurpassed thermal stability and up to five times the service life of conventional ATFs. Delivers maximum protection for towing and other severe-duty applications. Product Code: ATF\nFor DEXRON®III, MERCON®, Ford M2C138-CJ, Ford M2C166-H and Chrysler ATF Plus, MS-7176B Applications.\nRecommended for use in applications requiring Honda Z-1 transmission fluids.\nUse where ATF is recommended in Mobile or Stationary Hydraulic and Power Steering units.\nRecommended for applications requiring the following specifications:\nGM Dexron II, Dexron III\nFord Mercon, Mercon V\nChrysler ATF+, ATF+2, ATF+3, ATF+4\nMitsubishi Diamond SP II & III\nAllison C-3 & C-4 and TES-295\nCaterpillar Powershift Transmission TO-2 & TO-3\nVoith Commercial Transmissions\nGM Strasbourg (European Imports) and Opel\nApplications requiring Honda Z-1 transmission fluids\nAMSOIL Synthetic Automatic Transmission Fluid exceeds the performance requirements for domestic and foreign automatic transmission fluid applications. AMSOIL ATF provides automatic transmissions, power steering units and hydraulic equipment with excellent lubricating protection and better performance over a wider temperature range than do conventional petroleum fluids.\nResists Oxidation and Thermal Degradation\nAMSOIL ATF resists thermal and oxidative degradation up to three to five times longer than conventional transmission fluids do. It protects clutches, planetary gears, valves, pumps and seals from damaging sludge and varnish deposits. AMSOIL ATF helps prevent component overheating and ensures cooler, smoother transmission operation.\nProvides Low Temperature Protection\nAMSOIL ATF outperforms petroleum fluids in low temperature fluidity. In fact, AMSOIL ATF offers three times the cold temperature fluidity required by current automatic transmission fluid specifications. AMSOIL ATF provides easier starting, faster warm-ups, smoother shifting and improved fuel economy.\nAMSOIL ATF provides smooth shifting and long, trouble-free transmission life. In addition, the anti-wear additive package makes AMSOIL ATF an excellent lubricant in other hydraulic systems. In tests designed to measure wear characteristics under severe service and high pressure operating conditions, AMSOIL ATF far exceeds the requirements of hydraulic equipment manufacturers.\nExtended Drain Intervals\nAMSOIL ATF is formulated for extended drain intervals. Transmissions usually operate under severe service conditions. They are subjected to extensive idling, frequent short trips, cold temperature driving, sustained hot weather driving or trailer towing. When conventional transmission fluid is used, it should be changed every 15,000 to 30,000 miles. AMSOIL ATF should be changed at intervals up to three times longer than the recommendations of the vehicle manufacturer.\nAMSOIL Synthetics Automatic Transmission Fluid is completely compatible with other synthetic and petroleum automatic transmission fluids. AMSOIL ATF is a universal, multifunctional fluid and greatly reduces the need for specialized fluid inventories and the possibilities of misapplication.\nAMSOIL ATF has an expected fluid life of three times the automatic transmission manufacturer'* recommendations. Drain intervals may be extended indefinitely when fluid analysis is used.\nTYPICAL TECHNICAL PROPERTIES\nAMSOIL 100% Synthetic Automatic Transmission Fluid (ATF)\nKinematic Viscosity @ 100°C, cSt (ASTM D-445)\nKinematic Viscosity @ 40°C, cSt (ASTM D-445)\nViscosity Index (ASTM D-2270)\nNoack Volatility, % weight loss (DIN 51581) 10.8\nFlash Point °C (°F) (ASTM D 92) 222 (432)\nPour Point °C (°F) (ASTM D 97)\nFour Ball Wear Test (ASTM D 4172B: 40 kg, 75°C, 1200 rpm, 1 hour, Scar in mm) 0.40\nBrookfield Viscosity (cP) -10°C = 465\nBrookfield Viscosity (cP) -20°C = 1030\nBrookfield Viscosity (cP) -30°C = 2505\nBrookfield Viscosity (cP) -40°C = 7150", "domain": "chemistry", "round": 3} +{"url": "http://mjpg.webs.uvigo.es/", "date": "2015-11-30T06:11:43Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2015-48/segments/1448398461113.77/warc/CC-MAIN-20151124205421-00123-ip-10-71-132-137.ec2.internal.warc.gz", "language_score": 0.9472770094871521, "token_count": 315, "dump": "CC-MAIN-2015-48", "global_id": "webtext-fineweb__CC-MAIN-2015-48__0__19882602", "lang": "en", "text": "In the years after the first thesis, she enrolled as PostDoctoral Fellow the group of Applied Physics at the University of Vigo. This represented a change in the type of fluid systems studied, with an approach more focused to industry. The experience from previous years allowed her to successfully address the study of dispersions of nanoparticles in thermal fluids, allowing her to participate and contribute to the successful development of two research projects. During these years she acquired training in the measurement of physical properties such as density, thermal conductivity and also got acquainted with rheology, which allows characterizing the viscoelastic properties of the materials under study and gives information about the structure of materials. The studies concerning rheology of non Newtonian nanofluids are pioneering, as for the first time a rigorous characterization of the anomalous viscoelastic behavior of these type of nanocolloids has been completed, analyzing the influences of variables ranging from size and polidispersity to magnetic nature of the suspended nanoparticles. In this period she defended a second Ph. D. thesis in Applied Physics, and also established partnerships and scientific collaboration with several research groups in Portugal..\nAt present she is working with a Postdoctoral Grant in the University of Minho, Portugal, in collaboration with the Group of Polymer Engineering, in the framework of a project whose main objective is the development of conductive polymers obtained by reinforcing load, specifically focusing on carbon nanotubes and graphene.\nIf you want to learn more about this scientific contribution please go to the Reseach section.", "domain": "chemistry", "round": 3} +{"url": "https://www.ornl.gov/staff-profile/beth-l-armstrong", "date": "2018-09-25T15:37:56Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-39/segments/1537267161661.80/warc/CC-MAIN-20180925143000-20180925163400-00438.warc.gz", "language_score": 0.8468883037567139, "token_count": 904, "dump": "CC-MAIN-2018-39", "global_id": "webtext-fineweb__CC-MAIN-2018-39__0__31614951", "lang": "en", "text": "Beth L Armstrong\nBeth L Armstrong\nBeth joined Oak Ridge National Laboratory (ORNL) to work on the development of functional materials and coatings. This work includes the development of alternative forming techniques for oxygen and NOx sensors, solid oxide fuel cells, gas separation devices, and corrosion resistant coatings.\n- M.S., Material Science and Engineering, University of California, Los-Angeles, California, 2000\n- B.S., Ceramic Engineering, University of Illinois, Champaign-Urbana, Illinois, 1988\nBeth has over 13 years of experience in the area of ceramic processing. Prior to joining ORNL, Beth worked at Pacific Northwest National Laboratory (PNNL) for 8 years and Garrett Ceramic Components for 4 years. At PNNL, her research activities included the extrusion of tubular supports for oxygen separation membranes, slip casting of electrochemical cells, the development of compression molding technology to fabricate complex planar components for fuel cells and oxygen generators, processing of resorbable and implantable bio-ceramic devices, synthesis and processing of nanoparticles, fabrication of catalyst supports and membranes, processing of biomaterials, the development of a resorbable bone filler and ceramic net shape forming techniques. At Garrett Ceramic Components, Beth evaluated gelcasting of silicon nitride components for use in automotive and aerospace applications. In addition, she worked within a team to develop processing methods for net shape fabrication of complex shapes and to understand the rheology of suspensions for slip casting. Other activities included compositional development, high-temperature mechanical property evaluation, and corrosion studies of silicon nitride.\n- American Ceramic Society\n- V. Vaubert, B.L. Armstrong, M. Janney, C. Walls, D. Stinton, etal. \"Design and Development of a Ceramic Hot-Gas Filter for Fossil Energy,\" Proceedings of the 14th Annual Conference on Fossil Energy Materials, Oak Ridge TN, May 2000, R.R. Judkins, ed..\n- B.L. Armstrong, L. Song, P.A. Smith, G.W. Coffey, \"Processing and Characterization of Biomaterials,\" Proceedings of the 30th Annual IMS Convention, Seattle, Washington, July, 1997.\n- B.L. Armstrong and K.L. Simmons, \"Manufacturing of Planar Ceramic Interconnects,\" Proceedings of the 1996 Fuel Cell Seminar, Orlando, Florida (1996).\n- B.L. Armstrong, \"Consolidation of Nanocrystalline ZrO2,\" Materials and Manufacturing Processes, 12, 1012, (1996).\n- J.W. Stevenson, B.L. Armstrong, T.R. Armstrong, J.L. Bates, L.R. Pederson, and W.J. Weber, \"Mixed Oxygen Ion/Electron-Conducting Ceramics for Oxygen Separation,\" Proceedings of the Eighth Annual Conference on Fossil Energy Materials, Oak Ridge TN, May 1995.\n- B.L. Armstrong, \"Synthesis and Processing of Nanocrystalline ZrO2,\" Proceedings from the NIST Nanomaterials Processing Workshop, Gaithersburg, Maryland, July 1995.\n- JW Stevenson, TR Armstrong, BL Armstrong, JL Bates, G Hsieh, LR Pederson, and WJ Weber, \"Mixed Oxygen Ion/Electron-Conducting Ceramics for Oxygen Separation,\" Proceedings of the 10th Annual Conference on Fossil Energy Materials, N. C. Cole and R. R. Judkins, eds., CONF 9605167, ORNL/FMP-96/1, Oak Ridge, Tennessee, p. 117 (1995).\n- O. O. Omatete, R. A. Strehlow, and B. L. Armstrong, \"Forming of Silicon Nitride by Gelcasting,\" Proceedings of the Annual Automotive Technology Development Contractors' Coordination Meeting, P-243, pp. 245-51 Society of Automotive Engineers, Warrendale, Pennsylvania (1991).\n- B.L. Armstrong, \"Issues of Consolidation of Nanoparticulate Materials,\" Proceedings from the Gorham Intertech First Annual Nanoparticulate Conference, Monterey, California, November, 1994.", "domain": "chemistry", "round": 3} +{"url": "https://www.boomerangbooks.com.au/solid-waste-as-a-renewable-resource/jimmy-alexander-faria-albanese/book_9781771882439.htm", "date": "2021-09-29T01:17:14Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-39/segments/1631780061350.42/warc/CC-MAIN-20210929004757-20210929034757-00411.warc.gz", "language_score": 0.9334515333175659, "token_count": 616, "dump": "CC-MAIN-2021-39", "global_id": "webtext-fineweb__CC-MAIN-2021-39__0__167461652", "lang": "en", "text": "1300 36 33 32\nThis title includes a number of Open Access chapters.\nThe twenty-first century world faces several enormous challenges: how to mitigate climate change, meet a growing energy demand without relying on fossil fuels, and manage the escalating quantities of solid waste generated by cities around the world. This compendium volume offers a viable solution to all three: using solid waste as a renewable resource.\nIntended for a wide audience ranging from engineers and academics to decision-makers in both the public and private sectors, this volume has gathered together research into a range of technologies and methodologies. The editors, two well-published researchers at the top of their field, have selected articles that lay the foundation for this discussion. They have then included chapters for the following waste management scenarios: anaerobic digestion, composting, pyrolysis and chemical upgrading, incineration and carbonization, and gasification.\nResearch has been included from around the world, representing potential international solutions to what are global challenges, as well as crucial implications for ongoing research in this important field of study.\nBuy Solid Waste as a Renewable Resource by Jimmy Alexander Faria Albanese from Australia's Online Independent Bookstore, Boomerang Books.\nBook DetailsISBN: 9781771882439\n» Have you read this book? We'd like to know what you think about it - write a review about Solid Waste as a Renewable Resource book by Jimmy Alexander Faria Albanese and you'll earn 50c in Boomerang Bucks loyalty dollars (you must be a Boomerang Books Account Holder - it's free to sign up and there are great benefits!)\nJimmy Faria is senior scientist at Abengoa Research, a R&D division of Abengoa. He is a chemical engineer and obtained a PhD from the University of Oklahoma (USA) in 2012. His research at the School of Chemical, Biological and Material Science at the University of Oklahoma (USA) is focused on the catalytic conversion of biomass-derived compounds in a novel nanoparticle stabilized emulsion system developed in this group, as well as on the synthesis, characterization, and applications of amphiphilic nanohybrids (e.g., enhanced oil recovery). Maria Pilar Ruiz-Ramiro is senior scientist at Abengoa Research, a R&D division of Abengoa. She is a chemical engineer and obtained a PhD from the University of Zaragoza (Spain) in 2008. She later worked as research associate with Daniel E. Resasco at the School of Chemical, Biological and Material Science at the University of Oklahoma (USA). Her research is focused on the thermochemical conversion of biomass, synthesis, and characterization of carbon solids (carbon nanotubes, biomass char, and soot), and the development of nanostructured catalysts for biofuels up-grading reactions.\n© 2003-2021. All Rights Reserved. Eclipse Commerce Pty Ltd - ACN: 122 110 687 - ABN: 49 122 110 687", "domain": "chemistry", "round": 3} +{"url": "http://mingen.hk/ilvaite.html", "date": "2021-11-28T06:03:41Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-49/segments/1637964358469.34/warc/CC-MAIN-20211128043743-20211128073743-00026.warc.gz", "language_score": 0.8079383373260498, "token_count": 691, "dump": "CC-MAIN-2021-49", "global_id": "webtext-fineweb__CC-MAIN-2021-49__0__179805969", "lang": "en", "text": "Sorosilicate, lawsonite group\nSpecific gravity: 3.99 to 4.05\nHardness: 5½ to 6\nStreak: Black, inclining to green or brown\nColour: Iron-black, dark grayish black\nSolubility: Gelatinises with hydrochloric acid\nCommon impurities: Mg,Mn\nPlutonic igneous environments\nIlvaite is a rare sorosilicate primarily found in iron-rich metamorphosed\ndolostone or zinc and\ncopper deposits; less commonly it is found as a minor mineral in\nmafic and ultramafic rocks either as a late-stage\nprimary mineral or as the result of hydrothermal alteration\n(Mines & Minerals 25.39). It also occurs in sodalite -\nsyenite and in\nAssociated minerals include quartz, magnetite,\nhedenbergite, sphalerite and\nThe Two Mile and Three Mile deposits, Paddy's River, Paddys River District, Australian Capital Territory, Australia, are skarn deposits at the contact between granodiorite and volcanic rocks. Ilvaite is a primary silicate that occurs rarely with quartz, magnetite, andradite and nontronite at the Two Mile deposit (AJM 22.1.35).\nAt Fengjiashan, Hubei, China, ilvaite occurs on quartz or calcite (MinRec 38.1.37).\nIn the Deccan traps of India, ilvaite is found only in the basalt of the Kurar quarry, Bombay-Malad, growing on quartz and second-generation calcite, but even there it is infrequent. It is associated with quartz, calcite, hematite, pumpellyite and rarely andradite, but never with babingtonite or julgoldite (MinRec 34.1.50).\nAt the type locality, Torre di Rio - Santa Filomena area, Elba Island, Italy, ilvaite occurs as aggregates with pyroxene and dolomite (Dana).\nAt the Los Remedios mine, Taxco mining district, Mexico, ilvaite has been found with overgrowths of rhodochrosite and fluorite (MinRec 42.5.430).\nAt Dalnegorsk, Russia, hedenbergite pseudomorphs after ilvaite have been found (KL p229).\nAt Whin Sill, Teesdale, England, UK, ilvaite has been found in mafic-pegmatite veinlets, associated with ilmenite, titanite and apatite. The ilmenite may form pseudomorphs after titaniferous magnetite. The ilvaite encloses small grains of zircon, rutile, pyrrhotite, chalcopyrite and sphalerite (M&M 25.39).\nBack to Minerals", "domain": "chemistry", "round": 3} +{"url": "https://www.creativebiomart.net/recombinant-mouse-tgf-beta-1-protein-503990.htm", "date": "2019-10-15T19:50:52Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-43/segments/1570986660231.30/warc/CC-MAIN-20191015182235-20191015205735-00533.warc.gz", "language_score": 0.747284471988678, "token_count": 371, "dump": "CC-MAIN-2019-43", "global_id": "webtext-fineweb__CC-MAIN-2019-43__0__136880257", "lang": "en", "text": "|Product Overview:||Recombinant Mouse Tgfb1 Protein is produced by CHO Cells expression system.|\n|Form:||Lyophilized from a 0.2 μm filtered solution in HCl with BSA as a carrier protein.|\n|Bio-activity:||Measured by its ability to inhibit the IL-4-dependent proliferation of HT‑2 mouse T cells. Tsang, M. et al. (1995) Cytokine 7:389. The ED50 for this effect is 0.04-0.2 ng/mL.|\n|Molecular Mass:||12.8 kDa (monomer)|\n|Endotoxin:||<0.01 EU per 1 μg of the protein by the LAL method.|\n|Purity:||>95%, by SDS-PAGE under reducing conditions and visualized by silver stain|\n|Storage:||Avoid repeated freeze-thaw cycles.\n12 months from date of receipt, -20 to -70 centigrade as supplied.\n1 month, 2 to 8 centigrade under sterile conditions after reconstitution.\n3 months, -20 to -70 centigrade under sterile conditions after reconstitution.\n|Reconstitution:||Reconstitute at 50 μg/mL in 4 mM HCl containing at least 0.1% human or bovine serum albumin.|\n|Gene Name:||Tgfb1 transforming growth factor, beta 1 [ Mus musculus ]|\n|Synonyms:||TGFB1; transforming growth factor, beta 1; TGF-beta 1; TGF-beta-1; Tgfb; Tgfb-1; TGFbeta1; TGF-beta1;|", "domain": "chemistry", "round": 3} +{"url": "https://www.bcmaterials.net/event-post/?post_id=28677", "date": "2022-07-03T22:02:02Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-27/segments/1656104249664.70/warc/CC-MAIN-20220703195118-20220703225118-00142.warc.gz", "language_score": 0.8572218418121338, "token_count": 499, "dump": "CC-MAIN-2022-27", "global_id": "webtext-fineweb__CC-MAIN-2022-27__0__197397078", "lang": "en", "text": "Computational/Experimental Symbiosis in the Design of Supramolecular Architectures: From Structure to Spinal Cord Regeneration\nWe are pleased to announce the invited talk given by Ivan Sasselli, Research Associate of the Biomolecular Nanotechnology & Computational Biophysics Groups at CIC biomaGUNE.\nThe talk title is: “Computational/Experimental Symbiosis in the Design of Supramolecular Architectures: From Structure to Spinal Cord Regeneration”\nSupramolecular peptide polymers have demonstrated exceptional potential as materials for nanomedicine and biotechnology. Inspired by proteins, these biomaterials are highly tunable with interdependent structure and function that are encoded in the amino acid sequence. However, the connection between these three is not as well understood as in proteins. Thus, the design of functional materials has represented a major challenge, not being able to optimize materials performance. In this talk, we show how the symbiotic combination of computational and experimental methods has stood out as a distinctive approach to design supramolecular architectures. The computational methods are validated through experimental data, improving their inter interpretation in return to improve our understanding of the materials. This approach has allowed the optimization of materials for 3D printing and spinal cord regeneration.\nThe event will take place at the Martina Casiano auditorium. It can be also be followed online via Teams through this link: https://teams.microsoft.com/l/meetup-join/19%3ameeting_M2EzM2FjYmUtMGIxNS00YjQ3LWI0MTQtZjRkMGFmYjMzMmMx%40thread.v2/0?context=%7b%22Tid%22%3a%222f54ab68-83af-4d70-8895-a0d1e95ec899%22%2c%22Oid%22%3a%22bf8c59fd-187e-4a18-ac49-c2a36f44723c%22%2c%22IsBroadcastMeeting%22%3atrue%7d&btype=a&role=a\nDate(s) - 17/02/2022\n11:00 AM - 12:30 PM", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/katnal1-antibody-ab82422.html", "date": "2020-09-24T05:53:51Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-40/segments/1600400213454.52/warc/CC-MAIN-20200924034208-20200924064208-00797.warc.gz", "language_score": 0.6843547821044922, "token_count": 375, "dump": "CC-MAIN-2020-40", "global_id": "webtext-fineweb__CC-MAIN-2020-40__0__234162762", "lang": "en", "text": "Key features and details\n- Rabbit polyclonal to KATNAL1\n- Suitable for: IHC-P, WB\n- Reacts with: Human\n- Isotype: IgG\nProduct nameAnti-KATNAL1 antibody\nDescriptionRabbit polyclonal to KATNAL1\nTested applicationsSuitable for: IHC-P, WBmore details\nSpecies reactivityReacts with: Human\nPredicted to work with: Mouse, Rat\nSynthetic peptide derived from the C terminal domain of Human KATNAL1.\nStorage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.\nStorage bufferConstituent: Whole serum\nConcentration information loading...\nOur Abpromise guarantee covers the use of ab82422 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\n|IHC-P||1/50 - 1/200.|\n|WB||1/100 - 1/1000. Predicted molecular weight: 55 kDa.|\nFunctionSevers microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.\nSequence similaritiesBelongs to the AAA ATPase family.\nCellular localizationCytoplasm > cytoskeleton.\n- Information by UniProt\n- Katanin p60 ATPase containing subunit A like 1 antibody\n- Katanin p60 ATPase-containing subunit A-like 1 antibody\n- Katanin p60 subunit A like 1 antibody\nab82422 has not yet been referenced specifically in any publications.", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/recombinant-human-wee1-protein-tagged-ab271795.html", "date": "2021-10-21T23:52:46Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-43/segments/1634323585449.31/warc/CC-MAIN-20211021230549-20211022020549-00489.warc.gz", "language_score": 0.7811576724052429, "token_count": 991, "dump": "CC-MAIN-2021-43", "global_id": "webtext-fineweb__CC-MAIN-2021-43__0__122539235", "lang": "en", "text": "Key features and details\n- Expression system: Baculovirus infected Sf9 cells\n- Purity: >= 75% SDS-PAGE\n- Active: Yes\n- Tags: GST tag N-Terminus\n- Suitable for: SDS-PAGE, Functional Studies\nProduct nameRecombinant human Wee1 protein (Tagged)\nSee all Wee1 proteins and peptides\nSpecific Activity: ≥42 pmol/min/μg\nAssay Conditions: Assay was done in Kinase buffer containing 1 mM DTT using Poly-(Lys4:Tyr) substrate (0.2 mg/ml) and 20 μM ATP. Reaction was done at 30°C for 45 min. Amount of ATP transferred was calculated using Kinase-Glo reagent.\nPurity>= 75 % SDS-PAGE.\nExpression systemBaculovirus infected Sf9 cells\nProtein lengthProtein fragment\nSequenceDTEKSGKRE FDVRQTPQVN INPFTPDSLL LHSSGQCRRR KRTYWNDSCG EDMEASDYEL EDETRPAKRI TITESNMKSR YTTEFHELEK IGSGEFGSVF KCVKRLDGCI YAIKRSKKPL AGSVDEQNAL REVYAHAVLG QHSHVVRYFS AWAEDDHMLI QNEYCNGGSL ADAISENYRI MSYFKEAELK DLLLQVGRGL RYIHSMSLVH MDIKPSNIFI SRTSIPNAAS EEGDEDDWAS NKVMFKIGDL GHVTRISSPQ VEEGDSRFLA NEVLQENYTH LPKADIFALA LTVVCAAGAE PLPRNGDQWH EIRQGRLPRI PQVLSQEFTE LLKVMIHPDP ERRPSAMALV KHSVLLSASR KSAEQLRIEL NAEKFKNSLL QKELKKAQMA KAAAEERALF TDRMATRSTT QSNRTSRLIG KKMNRSVSLT IY\nPredicted molecular weight75 kDa including tags\nAmino acids215 to 646\nTagsGST tag N-Terminus\nAdditional sequence informationN-terminal GST-Thrombin-Tag\nOur Abpromise guarantee covers the use of ab271795 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\nConcentration information loading...\nPreparation and Storage\nStability and Storage\nShipped on Dry Ice. Store at -80°C. Avoid freeze / thaw cycle.\nConstituents: 0.63% Tris HCl, 0.64% Sodium chloride, 0.02% Potassium chloride, 0.04% Tween, 20% Glycerol (glycerin, glycerine), 0.06% Glutathione\nThis product is an active protein and may elicit a biological response in vivo, handle with caution.\n- EC 184.108.40.206\nFunctionActs as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15'. Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation.\nSequence similaritiesBelongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.\nContains 1 protein kinase domain.\nmodificationsPhosphorylated during M and G1 phases. Also autophosphorylated.\nUbiquitinated and degraded at the onset of G2/M phase.\n- Information by UniProt\nTo our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.\nab271795 has not yet been referenced specifically in any publications.", "domain": "chemistry", "round": 3} +{"url": "https://scholarworks.montana.edu/items/3f60d49e-cacc-4eb7-8f95-9f5c9cb60e9f", "date": "2024-04-22T16:16:10Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712296818312.80/warc/CC-MAIN-20240422144517-20240422174517-00206.warc.gz", "language_score": 0.857890784740448, "token_count": 335, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__87300071", "lang": "en", "text": "Retention and expression of recombinant plasmids in suspended and biofilm-bound bacteria degrading trichloroethene (tce)\nExposure of plasmid recombinant microorganisms to an open environment, either inadvertently or intentionally, requires research into those fundamental processes that govern plasmid retention, transfer and expression. In the open environment, a majority of the microbial activity occurs associated with an interface, within thin biological layers consisting of cells and their insoluble extracellular polymer, layers known as biofilms. Current toxic wastewater or wastegas treatment reactors exploit bacterial biofilm systems for certain system operating advantages. Using recombinant bacteria within a biofilm reactor to degrade xenobiotic wastes requires finding a suitable host to harbor and express the desired plasmid phenotype. Suitable host characteristics include: the ability to produce copious amounts of biofilm, resistance to waste-related injury and toxicity, and the ability to retain and express the desired plasmid during long term operation. This paper reports on a laboratory evaluation of factors governing plasmid retention and the expression of trichloroethene (TCE) degradative capacity in both suspended and biofilm cultures.\nBryers, J.D. and R.R. Sharp, “Retention and Expression of Recombinant Plasmids in Suspended and Biofilm-Bound Bacteria Degrading Trichloroethene (TCE), Water Science and Technology, 36(10):1-8 (1997).", "domain": "chemistry", "round": 3} +{"url": "https://pubmed.ncbi.nlm.nih.gov/20159030/?dopt=Abstract", "date": "2020-08-08T07:10:03Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-34/segments/1596439737289.75/warc/CC-MAIN-20200808051116-20200808081116-00334.warc.gz", "language_score": 0.9553746581077576, "token_count": 322, "dump": "CC-MAIN-2020-34", "global_id": "webtext-fineweb__CC-MAIN-2020-34__0__82176195", "lang": "en", "text": "Prostaglandin E synthase (PGES), which converts cyclooxygenase (COX)-derived prostaglandin H(2) (PGH(2)) to PGE(2), is known to comprise a group of at least three structurally and biologically distinct enzymes. Two of them are membrane-bound and have been designated as mPGES-1 and mPGES-2. mPGES-1 is a perinuclear protein that is markedly induced by proinflammatory stimuli and downregulated by anti-inflammatory glucocorticoids as in the case of COX-2. It is functionally coupled with COX-2 in marked preference to COX-1. mPGES-2 is synthesized as a Golgi membrane-associated protein, and the proteolytic removal of the N-terminal hydrophobic domain leads to the formation of a mature cytosolic enzyme. This enzyme is rather constitutively expressed in various cells and tissues and is functionally coupled with both COX-1 and COX-2. Cytosolic PGES (cPGES) is constitutively expressed in a wide variety of cells and is functionally linked to COX-1 to promote immediate PGE(2) production. Recently, mice have been engineered with specific deletions in each of these three PGES enzymes. In this review, we summarize the current understanding of the in vivo roles of PGES enzymes by knockout mouse studies and provide an overview of their biochemical properties.\nCopyright 2010 Elsevier Masson SAS. All rights reserved.", "domain": "chemistry", "round": 3} +{"url": "https://www.aboutlawsuits.com/afff-military-costs-report-185352/", "date": "2023-09-21T14:45:04Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233506028.36/warc/CC-MAIN-20230921141907-20230921171907-00813.warc.gz", "language_score": 0.965081512928009, "token_count": 818, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__145307508", "lang": "en", "text": "Removing Firefighter Foam Chemicals From Military Bases Could Cost $2.1B: GAO Report\nA new report by federal officials estimates cleaning firefighter foam chemical contamination on military bases could cost U.S. taxpayers billions of dollars.\nThe Government Accountability Office (GAO) issued a report (PDF) to congress this month, calling for the Department of Defense (DOD) to release more information about the price of cleaning up per- and polyfluoroalkyl substances (PFAS) from various military bases nationwide. However, the report suggests that price tag will likely exceed $2.1 billion.\nPFAS are a chemical component of aqueous film-forming foams (AFFFs), which are used to fight petroleum-based fires, and are commonly used on bases during training for both military and civilian firefighters.\nThe chemicals are known to persist in soil and can lead to water contamination. This is, in part, because PFAS do not break down and stay in the environment, and the human body, for extremely long periods of time, which has earned them the nickname “forever chemicals.”\nPFAS were first introduced into the manufacturing industry in the 1940’s, because of their ability to resist heat, grease, stains, and water. However, since then the chemicals have been linked to a myriad of adverse health effects including liver damage, thyroid disease, decreased fertility, high cholesterol, obesity, hormone suppression, and cancer.\nAccording to the GAO report, the DOD is in the beginning stages of cleaning PFAS contamination on, or near, 687 military installations. Last year, those efforts cost about $1.1 billion. However, the report indicates fiscal year 2021 PFAS remediation efforts will cost another $2.1 billion.\n“These costs will likely increase significantly, because DOD is still in the early phases of its PFAS investigation. DOD officials also cited regulatory uncertainty at the federal and state levels as a significant challenge in estimating PFAS environmental restoration costs,” the GAO report states. “However, DOD has not reported future PFAS cost estimates, or the scope and limitations of those estimates, in its annual environmental report to Congress.”\nThe GAO indicates if DOD can and does report those estimates to Congress, it would ensure lawmakers are not broadsided by the increasing costs and efforts associated with PFAS investigation and cleanup operations at military bases nationwide.\nCleanup and remediation efforts cover a broad range of activities, including installing water treatment systems and even just providing bottled water to residents whose drinking water sources are now contaminated.\nIt is projected to take thousands of years for PFAS to degrade, and past studies have shown their ability to enter and stay in the environment and human body through the air, dust, food, soil, and water. Previous U.S. Centers for Disease Control and Prevention studies have shown PFAS chemicals primarily settle into the blood, kidney and liver, and could likely be detected in the blood of 98% of the U.S. population.\nChemical manufacturers now face a growing number of firefighting foam lawsuits brought by individuals nationwide, including former fire fighters diagnosed with cancer and individuals who lived near military bases or training facilities where chemicals from the toxic foam contaminated drinking water supplies. The companies may also face massive liability for PFAS cleanup costs associated with the contamination caused by the chemicals that they sold for decades.\n\"*\" indicates required fields\nMore Top Stories\nUber faces a lawsuit from four passengers who say they were sexually assaulted by drivers, due to the company's lack of security measures and focus on passenger safety.\nA Bard PowerPort lawsuit claims the defective design of the port catheter led to a woman developing a severe infection and needing to have the implant surgically removed.\nThe new federal judge overseeing all talcum powder lawsuits has called for a Science Day to educate the court ahead of planned Daubert hearings which could decide if bellwether test trials can move forward.", "domain": "chemistry", "round": 3} +{"url": "https://lmmks.com/common-food-additive-located-to-affect-intestine-microbiota/", "date": "2021-10-19T14:15:52Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-43/segments/1634323585270.40/warc/CC-MAIN-20211019140046-20211019170046-00013.warc.gz", "language_score": 0.9534850716590881, "token_count": 766, "dump": "CC-MAIN-2021-43", "global_id": "webtext-fineweb__CC-MAIN-2021-43__0__176951523", "lang": "en", "text": "Experts name for higher regulation of a not unusual additive in foods and remedy, as research exhibits it can impact the gut microbiota and make contributions to infection within the colon, that can trigger diseases including inflammatory bowel illnesses and colorectal most cancers.\nUniversity of Sydney studies provides new evidence that nanoparticles, which can be present in many meals gadgets, can also have a large and harmful effect on human fitness.\nThe study investigated the fitness impacts of food additive E171 (titanium dioxide nanoparticles) that are typically used in high portions in meals and a few drugs as a whitening agent. Found in greater than 900 meals products such as chewing gum and mayonnaise, E171 is consumed in excessive proportion ordinary through the overall populace.\nPublished in Frontiers in Nutrition, the mice take a look at located that consumption of food containing E171 has an effect on the gut microbiota (defined by the trillions of microorganism that inhabit the gut) which can cause illnesses together with inflammatory bowel diseases and colorectal cancer.\nCo-lead creator Associate Professor Wojciech Chrzanowski stated the take a look at added significantly to a frame of labor on nanoparticle toxicity and safety and their effect on health and environment.\n“The intention of this studies is to stimulate discussions on new requirements and guidelines to make sure safe use of nanoparticles in Australia and globally,” he said.\nWhile nanoparticles were generally utilized in drugs, meals, apparel, and other applications, the viable effects of nanoparticles, mainly their long time outcomes, are nonetheless poorly understood.\nTitanium dioxide consumption has drastically expanded within the last decade and has already been connected to numerous medical conditions, and although it is accredited in meals, there may be inadequate evidence approximately its safety.\nIncreasing charges of dementia, car-immune sicknesses, cancer metastasis, eczema, allergies, and autism are among a growing listing of sicknesses that have been connected to soaring exposure to nanoparticles.\n“It is nicely mounted that dietary composition has an impact on physiology and health, yet the role of meals additives is poorly understood,” said Associate Professor Chrzanowski, a nanotoxicology expert from the University of Sydney’s School of Pharmacy and Sydney Nano Institute.\n“There is growing evidence that non-stop publicity to nanoparticles has an effect on gut microbiota composition, and due to the fact that gut microbiota is a gatekeeper of our health, any changes to its function have power on average fitness.”\n“This look at affords pivotal evidence that intake of meals containing meals additive E171 (titanium dioxide) affects gut microbiota in addition to inflammation in the gut, which can cause diseases along with inflammatory bowel sicknesses and colorectal most cancers,” he said.\nCo-lead creator Associate Professor Laurence Macia from the University of Sydney said: “Our research confirmed that titanium dioxide interacts with microorganism within the intestine and impairs a number of their functions which may bring about the development of illnesses. We are pronouncing that its consumers need to be better regulated via food authorities.”\n“This study investigated consequences of titanium dioxide on gut fitness in mice and located that titanium dioxide did no longer alternate the composition of intestine microbiota, but rather it affected microorganism pastime and promoted their increase in a shape of undesired biofilm. Biofilms are bacteria that stick together and the formation of biofilm has been mentioned in illnesses which includes colorectal most cancers,” stated Associate Professor Macia, who’s an immunologist expert on the influences of the gut and gut microbiota on health from the Faculty of Medicine and Health and the Charles Perkins Centre.", "domain": "chemistry", "round": 3} +{"url": "https://arrow.tudublin.ie/schfsehbk/5/", "date": "2022-07-04T06:52:06Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-27/segments/1656104354651.73/warc/CC-MAIN-20220704050055-20220704080055-00339.warc.gz", "language_score": 0.8555464148521423, "token_count": 334, "dump": "CC-MAIN-2022-27", "global_id": "webtext-fineweb__CC-MAIN-2022-27__0__276735481", "lang": "en", "text": "This item is available under a Creative Commons License for non-commercial use only\nFucoxanthin is a bioactive compound found in one of the most prolific and sustainable organisms on the planet, alga. Its efficacy and potential in terms of health applications have been widely reported in clinical studies. Technical modifications, such as encapsulation, and sensory trials must be undertaken before fucoxanthin can be successfully utilised as a functional food ingredient. Factors to consider include solubility in the food matrix, organoleptic effects, stability, preservation against oxidation, consumer acceptability, bioavailability, and toxicity risk. Possible solutions may include the development of more efficient and greener extraction technologies, which require shorter extraction times and less solvent, and have a more specific and higher extraction yield. The sustainability of potential seaweed cultivars must be assessed before large-scale harvesting, to ensure the preservation of this precious marine resource.\nAbu-Ghannam, N. and Shannon, E. (2017) Seaweed Carotenoid, Fucoxanthin, as Functional Food, in Microbial Functional Foods and Nutraceuticals (eds V. K. Gupta, H. Treichel, V. (O). Shapaval, L. Antonio de Oliveira and M. G. Tuohy), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9781119048961.ch3", "domain": "chemistry", "round": 3} +{"url": "https://www.integrativemedicalny.com/contents/conditions/detoxification", "date": "2019-07-16T23:06:48Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-30/segments/1563195524972.66/warc/CC-MAIN-20190716221441-20190717003441-00401.warc.gz", "language_score": 0.9412932991981506, "token_count": 275, "dump": "CC-MAIN-2019-30", "global_id": "webtext-fineweb__CC-MAIN-2019-30__0__201180016", "lang": "en", "text": "DETOXIFICATION AND BIOTRANSFORMATION\nLike any process involving construction and demolition, our bodies build and remove substances constantly. The removal process is called biotransformation or detoxification. The liver is the primary organ of biotransformation, which has two distinct processes: Phase 1 by way of the actions of the Cytochrome P450 system… and Phase 2, which involves the alteration of these intermediary products to water soluble substances. These are excreted by the kidneys and the other organs of elimination: the colon and sweat glands.\nThe circumstances of modern life have tremendous impact on our detoxification systems. For starters, there is the overload of toxic substances we acquire from the environment. Thousands of novel chemicals have been introduced into the environment with inadequate safety testing, forcing us to try to detoxify substances that our systems were not designed to process.\nAdding even more stress to our already overburdened detox systems, our modern food supply does not provide the proper nutrients in sufficient quantities to support detoxification, while overwhelming our bodies with preservatives, genetically modified foods, and antibiotics. Other activities such as excessive exercise, inadequate sleep, and alcohol consumption add to the burden. Supporting biotransformation can alleviate symptoms such as fatigue, headaches, malaise, and depression.\nThe Toxin Solution by Joseph Pizzorno, ND", "domain": "chemistry", "round": 3} +{"url": "http://www.terrificpets.com/pet_supplies/fish/conditioners-additives/enzymes/3263.asp", "date": "2013-12-05T13:23:19Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2013-48/segments/1386163045148/warc/CC-MAIN-20131204131725-00001-ip-10-33-133-15.ec2.internal.warc.gz", "language_score": 0.9160528182983398, "token_count": 263, "dump": "CC-MAIN-2013-48", "global_id": "webtext-fineweb__CC-MAIN-2013-48__0__122479163", "lang": "en", "text": "Freshwater Biozyme is a living system of beneficial bacteria in concentrated form, which is activated upon introduction to water. It converts lethal ammonia and nitrite to less harmful nitrate. It quickly reduces fish waste to inert substances and breaks down organic buildup in gravel beds. Freshwater Biozyme has unlimited shelf life, as opposed to liquid enzymes. These bacteria contribute to the production of the nitrogen cycle which is critical to all aquatic systems. This material gives you the option of increasing the activity of an already established filter, or reactivating a filter damaged by medications. Helps prevent \"new tank syndrome\" when used for establishing new aquariums.\nDirections: Use 1/4 teaspoon for 25 gallons of water directly in the aquarium. Every week, add 1/8 teaspoon per 25 gallons to avoid pollution and for nitrate reduction. Use only as directed. Slightly overdosing does no harm, but is not necessary. This product will be replaced or refunded if defective in manufacture. Except for such replacement, there is no warranty of liability-even if loss is caused by negligence or fault. Keep out of the reach of children. Caution: Not for human consumption. For aquarium ornamental fish use only. Not for fish or livestock used for human consumption. After opening, store in a cool, dry place.", "domain": "chemistry", "round": 3} +{"url": "https://cris.bgu.ac.il/en/publications/flexible-and-bio-compatible-temperature-sensors-based-on-carbon-n", "date": "2022-01-29T15:01:05Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-05/segments/1642320306181.43/warc/CC-MAIN-20220129122405-20220129152405-00132.warc.gz", "language_score": 0.8282443881034851, "token_count": 286, "dump": "CC-MAIN-2022-05", "global_id": "webtext-fineweb__CC-MAIN-2022-05__0__168511669", "lang": "en", "text": "Flexible temperature sensors are desired for a wide range of applications in engineering, biology, and medicine. In the present paper, we describe the development of novel flexible temperature sensors based on carbon nanotube (CNT) forest composites, and we demonstrate their ability to sense on-skin temperatures. The fabrication process of these sensors is simple and they demonstrate bio-compatibility, high performance, and a simple sensing scheme. When subjected to high temperatures, the CNTs are strained due to the thermal mismatch between the CNT forest and the matrix, which modifies their electrical resistance in a stable and reproducible temperature–resistance relationship. The sensors demonstrate sensitivities of ~0.1Ω/°C or higher, and show stable Young's modulus of ~0.1MPa for temperatures below 100 °C. These sensors, thus, pave the way toward a new generation of flexible, wearable, and bio-compatible temperature sensors, which can be used as flexible lab-on-a-chip devices or as a sensory artificial skin.\n|Journal||Measurement: Journal of the International Measurement Confederation|\n|State||Published - 1 Feb 2021|\n- Carbon nanotube forests\n- Composite sensors\n- Temperature sensors", "domain": "chemistry", "round": 3} +{"url": "https://experts.umn.edu/en/publications/inhibitory-mechanisms-of-tea-polyphenols-on-the-ultraviolet-b-act", "date": "2023-02-08T02:15:13Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-06/segments/1674764500664.85/warc/CC-MAIN-20230207233330-20230208023330-00085.warc.gz", "language_score": 0.9170283079147339, "token_count": 399, "dump": "CC-MAIN-2023-06", "global_id": "webtext-fineweb__CC-MAIN-2023-06__0__261439831", "lang": "en", "text": "In this study, we investigated the effect of tea polyphenols, (-)-epigallocatechin-3-gallate or theaflavins, on UVB-induced phosphatidylinositol 3-kinase (PI3K) activation in mouse epidermal JB6 Cl 41 cells. Pretreatment of cells with these polyphenols inhibited UVB-induced PI3K activation. Furthermore, UVB-induced activation of Akt and ribosomal p70 S6 kinase (p70 S6-K), PI3K downstream effectors, were also attenuated by the polyphenols. In addition to LY294002, a PI3K inhibitor, pretreatment with a specific mitogen-activated protein/extracellular signal-regulated protein kinases (Erks) kinase 1 inhibitor, U0126, or a specific p38 kinase inhibitor, SB202190, blocked UVB-induced activation of both Akt and p70 S6-K. Pretreatment with LY294002 restrained UVB-induced phosphorylation of Erks, suggesting that in UVB signaling, the Erk pathway is mediated by PI3K. Moreover, pretreatment with rapamycin, an inhibitor of p70 S6-K, inhibited UVB-induced activation of p70 S6-K, but UVB-induced activation of Akt did not change. Interestingly, UVB-induced p70 S6-K activation was directly blocked by the addition of (-)-epigallocatechin-3-gallate or theaflavins, whereas these polyphenols showed only a weak inhibition on UVB-induced Akt activation. Because PI3K is an important factor in carcinogenesis, the inhibitory effect of these polyphenols on activation of PI3K and its downstream effects may further explain the anti-tumor promotion action of these tea constituents.", "domain": "chemistry", "round": 3} +{"url": "http://fingerprintmaryland.com/2019/08/22/lets-talk-cannabis-terpenes-101/", "date": "2019-10-23T12:46:52Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-43/segments/1570987833766.94/warc/CC-MAIN-20191023122219-20191023145719-00458.warc.gz", "language_score": 0.8495970964431763, "token_count": 1033, "dump": "CC-MAIN-2019-43", "global_id": "webtext-fineweb__CC-MAIN-2019-43__0__125552332", "lang": "en", "text": "Let’s Talk Cannabis Terpenes\nHave you ever discovered your self in a cannabis dispensary up against numerous various fancy-sounding varieties of weed to pick from, being unsure of which ones to select and which ones you need really? Don’t stress because everyone else started this means: confused.\nhttps://cbdoilreviewer.net The very first thing you may want to do in terms of knowing the various strains and kinds of cannabis and their characteristics that are differentto learn about cannabis terpenes.\nTerpenes would be the aromatic natural compounds which can be contained in numerous plants. They have been also present in some bugs, too. Terpenes will be the crucial natural oils giving flowers their scents and their healing properties, making them the inspiration of aromatherapy.\nWorldwide CBD Exchange\nIn cannabis, it will be the terpenes that give weed its natural taste and therefore enhance the” that is“high encounter from smoking a joint. More over, terpenes additionally hold numerous benefits that are medicinal.\nThen when you discover cannabis varieties with distinctive tastes like berry, pine, mint, and citrus, for the reason that of terpenes.\nWhy cannabis has terpenes\nCannabis flowers have over 100 terpenes that are different.\nCannabis terpenes are secreted when you look at the glands that are same cannabinoids like tetrahydrocannabinol (THC) and cannabidiol (CBD) are manufactured. And simplylike many flowers that are strong-smelling flowers, cannabis flowers develop terpenes primarily for adaptive purposes, which will be to attract pollinators and repel predators.\nBut how come various cannabis strains and varieties have various terpene composition, this provides you with various odors and different impacts in the human body?\nEach stress of cannabis plant tends toward an unique type and structure of terpene. Many facets influence this. These facets consist of climate, weather, fertilizers utilized, soil kind, age, and maturation. Perhaps the period of The affects terpenes day.\nMany cannabis terpenes that are common\nWhile significantly more than one hundred terpenes have already been identified in cannabis, there are the ones which are considered most typical. Here you will find the most frequent cannabis terpenes and their respective traits:\nPossible Medicinal Value: found in the treating pain, ulcers, cancer tumors, asthma, irritation, and anxiety\nProspective Effects: memory retention, alertness, counteracts some THC results\nVaporizes at: 311?F (155?C)\nAlso present in: rosemary, pine needles, basil, dill, parsley\nAroma: cloves, cardamom, musky, earthy, herbal\nPossible Medicinal Value: antioxidant; remedy for sleeplessness, discomfort, and irritation\nPossible Results: sedating, relaxing\nVaporizes at: 332?F (167?C)\nAlso present in: lemongrass, mango, thyme, hops\nProspective Medicinal Value: utilized in the treating despair, anxiety, infection, cancer tumors, and discomfort\nPossible Results: stress relief, elevated mood\nVaporizes at: 348?F (176?C)\nAlso Found in: peppermint, fresh fresh fruit rinds, rosemary, juniper\nAroma: peppery, spicy, woody\nPossible Medicinal Value: utilized in the treating discomfort, ulcers, anxiety, and despair\nPossible Impacts: stress relief\nVaporizes at: 266?F (130?C)\nAlso present in: cloves, black pepper, cinnamon\nPossible Medicinal Value: utilized in the treating despair, anxiety, sleeplessness, swelling, discomfort, and disease that is neurodegenerative\nPossible Results: sedating, mood improving\nVaporizes at: 388?F (198?C)\nAlso Found in: lavender\nAroma: woodsy, earthy\nProspective Medicinal Value: anti-inflammatory\nVaporizes at: 222?F (106?C)\nAlso present in: coriander, hops, basil, cloves\nAroma: Sweet, woody, herbal\nPossible Medicinal Value: anti-fungal, antiviral, antiseptic, anti-bacterial, decongestant\nVaporizes at: 122?F (50?C)\nAlso present in: parsley, mint, pepper, mangoes, orchids, kumquats, and basil\nAroma: floral, piney, herbal\nProspective Medicinal Value: sedative, anti-bacterial, antioxidant, anti-fungal, anti-cancer\nProspective Results: soothing, sedating\nVaporizes at: 366?F (186?C)\nAlso Found in: lilacs, nutmeg, tea tree, apples, conifers, and cumin", "domain": "chemistry", "round": 3} +{"url": "https://injectorall.com/MSDS4G.htm", "date": "2020-04-04T21:58:37Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-16/segments/1585370525223.55/warc/CC-MAIN-20200404200523-20200404230523-00026.warc.gz", "language_score": 0.7781575918197632, "token_count": 841, "dump": "CC-MAIN-2020-16", "global_id": "webtext-fineweb__CC-MAIN-2020-16__0__85456930", "lang": "en", "text": "Buy Direct From Us\nLooking for those hard to find PC Boards? We have them cheaper than you can find elsewhere. If you see it cheaper, PLEASE give us a chance to beat that price for you. We have the widest variety of boards in the industry. If you don't see it, just ask. We have boards from .005\" thick to double sided boards with 4 oz. of copper on each side.\nONLY available at INJECTORALL\nMaterial Safety Data Sheet for Triso Flux Remover\nSection I Hazardous Ingredients / Identity Information\nHazardous Components OSHA ACGIH Other Limits\n(Specific Chemical Identity) PEL TLV\n1,1,1-Trichloroethane ( 71-55-6 ) 350 PPM TWA 350 PPM TWA NA\nIsopropanol ( 67-63-0 ) 400 PPM TWA 400 PPM TWA NA\nSection II Physical / Chemical Characteristics\nBoiling Point ( °F ) : ( concentrate ) 165\nSpecific Gravity ( H2O = 1 ): 1.28\nVapor Pressure @ 70° F: 100 psi\nHalting Point: - 41° F\nVapor Density ( Air = 1 ): >1\nEvaporation Rate: Solubility in water : About 34%\n( Butyl Acetate = 1 ) : 0.35\nAppearance & Odor: Clear colorless liquid with alcohol / ethereal odor\nSection III Fire and Explosion Hazard Data\nFlash Point ( °F ): NA\nFlammability Limit: LET: NA UEL: NA\nExtinguishing Media: Carbon Dioxide, dry chemical, foam, and water fog\nSpecial Firefighting Procedures: Self-contained respiratory protection should be provided for firemen\nfighting in buildings or confined areas.\nSection IV Reactivity Data\nConditions to Avoid: NA\nHazardous Polymerization: Will not occur\nConditions to Avoid: NA\nIncompatibility ( Material to Avoid ): Strong oxidizing agents and alkalies\nHazardous decomposition or products: Burns to form CO, CO2, HCL and possible traces of chlorine and phosgene\nSection V Health Hazard Data\nHealth Hazards ( Acute & Chronic ): Prolonged overexposure can cause central nervous system depression. Minimal anesthetic effects may be seen in the range of 500-1000 PPM. Contact with membrane can cause moderate irritation.\nIARC Monograph: No\nOSHA Regulated: No\nSigns and Symptoms of Exposure: Ingestion may cause abdominal cramps and diarrhea. Contact with skin can cause mild irritation and drying or flaking of skin.\nMedical Conditions Generally Aggravated by Exposure: None Known\nEmergency & First Aid Procedures: Move away from exposure source. Thoroughly wash contaminated eyes and skin with water. Give oxygen. Do not induce vomiting. Never give Adrenaline following overexposure.\nSection VI Precautions for Safe Handling and Use\nIn Case Material is Released or Spilled: Use absorbent sweeping liquid to soak up material. Put into container.\nWaste Disposal Method: Dispose of all waste in accordance with federal, state, and local regulations\nPrecautions to be taken in Handling or Storage: Keep away from heat, sparks, open flame or direct sunshine. Do not puncture or incinerate.\nOther Precautions: Intentional misuse by deliberately concentrating and inhaling vapor contents can be harmful or fatal.\nSection VII Control Measures\nRespiratory Protection: Necessary for normal use\nLocal Exhaust: None\nMechanical ( general ): None\nProtective Gloves: Necessary for normal use\nEye Protection: Safety goggles or face shield\nOther Protective Clothing or Equipment: Not necessary for normal use\nWork/Hygienic Practices: Wash hands after use\n40 Diamond Drive, Plainview NY 11803\nGeneral Information: firstname.lastname@example.org\nCopyright © 2003 Injectorall Electronics Corp.\nvisitors to this page since Last Modified: June 22, 2001", "domain": "chemistry", "round": 3} +{"url": "http://www.abcam.cn/ripx-antibody-ab89147.html", "date": "2017-08-17T06:18:49Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-34/segments/1502886102967.65/warc/CC-MAIN-20170817053725-20170817073725-00702.warc.gz", "language_score": 0.7096523642539978, "token_count": 431, "dump": "CC-MAIN-2017-34", "global_id": "webtext-fineweb__CC-MAIN-2017-34__0__93298258", "lang": "en", "text": "参阅全部 RIPX 一抗\nFull length Human RIPX (NP_055776.1).\n- Rat brain tissue lysate and RIPX transfected 293T cell lysate\n- 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.\n- 存储溶液Preservative: None\nConstituents: 1X PBS, pH 7.2\nConcentration information loading...\n- 纯度Protein A purified\nOur Abpromise guarantee covers the use of\nin the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\n||Use a concentration of 1 µg/ml. Predicted molecular weight: 53 kDa.\n- 功能Implicated in the formation of a single axon by developing neurons. May inhibit the formation of additional axons by inhibition of PI3K in minor neuronal processes.\n- 序列相似性Contains 1 RUN domain.\n- 翻译后修饰Isoform 1 is partially phosphorylated.\n- 细胞定位Cell projection. Enriched in F-actin enriched filopodia and lamellipodia of growth cones of axons and minor processes of hippocampal neurons in culture.\nInformation by UniProt\n- Protein RUFY3 antibody\n- rap2 interacting protein x antibody\n- Rap2 interacting protein x isoform 2 antibody\nAnti-RIPX antibody (ab89147)参考文献\nhas not yet been referenced specifically in any publications.\nPlease note: All products are \"FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE\"", "domain": "chemistry", "round": 3} +{"url": "https://ora.ox.ac.uk/objects/uuid:fe61070d-d72b-4696-88d8-5b9adfb7efed", "date": "2022-07-01T15:10:37Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-27/segments/1656103941562.52/warc/CC-MAIN-20220701125452-20220701155452-00187.warc.gz", "language_score": 0.6639035940170288, "token_count": 455, "dump": "CC-MAIN-2022-27", "global_id": "webtext-fineweb__CC-MAIN-2022-27__0__106629317", "lang": "en", "text": "QuaNCAT: quantitating proteome dynamics in primary cells.\n- Here we demonstrate quantitation of stimuli-induced proteome dynamics in primary cells by combining the power of bio-orthogonal noncanonical amino acid tagging (BONCAT) and stable-isotope labeling of amino acids in cell culture (SILAC). In conjunction with nanoscale liquid chromatography-tandem mass spectrometry (nanoLC-MS/MS), quantitative noncanonical amino acid tagging (QuaNCAT) allowed us to monitor the early expression changes of >600 proteins in primary resting T cells subjected to activation stimuli.\n- Publication status:\n- Peer review status:\n- Peer reviewed\n(Accepted manuscript, pdf, 1.7MB)\n- Publisher copy:\n- Pubs id:\n- Local pid:\n- Deposit date:\n- Copyright holder:\n- Nature America, Inc\n- Copyright date:\n- Copyright © 2013 Nature America, Inc. Citation: Howden, A. J. M., Geoghegan, V., Katsch, K., Efstathiou, G., Bhushan, B., Boutureira, O., … Acuto, O. (2013, March 10). QuaNCAT: quantitating proteome dynamics in primary cells. Nature Methods. Nature Publishing Group. http://doi.org/10.1038/nmeth.2401\nIf you are the owner of this record, you can report an update to it here: Report update to this record", "domain": "chemistry", "round": 3} +{"url": "https://www.naturesbest.co.uk/pharmacy/coughs-colds-flu/covonia-throat-spray-30ml/", "date": "2022-05-19T02:28:22Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-21/segments/1652662522741.25/warc/CC-MAIN-20220519010618-20220519040618-00024.warc.gz", "language_score": 0.8732737302780151, "token_count": 290, "dump": "CC-MAIN-2022-21", "global_id": "webtext-fineweb__CC-MAIN-2022-21__0__30020621", "lang": "en", "text": "Covonia Throat Spray is unique because it is the only dual action throat spray available in the UK. It contains two active ingredients, lidocaine and chlorhexidine. Lidocaine is a type of medicine called a local anaesthetic which numbs pain in the area it is applied to. Lidocaine does this by temporarily blocking the pathway of pain signals along nerves. Chlorhexidine is a disinfectant and antiseptic agent, which kills the micro-organisms associated with mouth and throat infections. Chlorhexidine is ideal treating various bacteria, bacterial spores, viruses and fungi.\nAdults and children over 12 years: 3 to 5 sprays, 6 to 10 times per day.\nThe active ingredients are: chlorhexidine gluconate 0.2% w/v, lidocaine hydrochloride monohydrate 0.05% w/v. The other ingredients are: citric acid (E330), glycerol (E422), saccharin sodium (E954), menthol, eucalyptol, ethanol, and purified water.\nSuitable For adults and children over the age of 12 years.\nDo not exceed the stated dose. Keep out of the reach and sight of young children. Not suitable for children under the age of 12 years. Do not use after the expiry date shown on the product packaging. If symptoms persist, seek medical consultation.", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/atf-4-antibody-n360a24-ab186284.html", "date": "2019-10-22T17:41:41Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-43/segments/1570987822458.91/warc/CC-MAIN-20191022155241-20191022182741-00175.warc.gz", "language_score": 0.6787459254264832, "token_count": 932, "dump": "CC-MAIN-2019-43", "global_id": "webtext-fineweb__CC-MAIN-2019-43__0__99236100", "lang": "en", "text": "Product nameAnti-ATF-4 antibody [N360A/24]\nSee all ATF-4 primary antibodies\nDescriptionMouse monoclonal [N360A/24] to ATF-4\nSpecificityab186284 has <50% identity with ATF5, it does not cross-react with this protein.\nTested applicationsSuitable for: IHC-Fr, WB, IHC-P, ICC/IFmore details\nSpecies reactivityReacts with: Human\nPredicted to work with: Mouse, Rat\nRecombinant fragment corresponding to Human ATF-4 aa 25-327.\nLGAEESLGLLDDYLEVAKHFKPHGFSSDKAKAGSSEWLAVDGLVSPSNNS KEDAFSGTDWMLEKMDLKEFDLDALLGIDDLETMPDDLLTTLDDTCDLFA PLVQETNKQPPQTVNPIGHLPESLTKPDQVAPFTFLQPLPLSPGVLSSTP DHSFSLELGSEVDITEGDRKPDYTAYVAMIPQCIKEEDTPSDNDSGICMS PESYLGSPQHSPSTRGSPNRSLPSPGVLCGSARPKPYDPPGEKMVAAKVK GEKLDKKLKKMEQNKTAATRYRQKKRAEQEALTGECKELEKKNEALKERA DSL\nDatabase link: P18848\n- WB: Rat brain lysate. ICC/IF: SK-N-BE cells.\nThe clone number has been updated from S360A-24 to N360A/24, both clone numbers name the same antibody clone.\nStorage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.\nStorage bufferpH: 7.40\nPreservative: 0.09% Sodium azide\nConstituents: PBS, 50% Glycerol\nConcentration information loading...\nPurityProtein G purified\nOur Abpromise guarantee covers the use of ab186284 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\n|IHC-Fr||Use at an assay dependent concentration.|\n|WB||1/1000. Detects a band of approximately 60 kDa (predicted molecular weight: 39 kDa).|\n|IHC-P||Use at an assay dependent concentration.|\n|ICC/IF||Use at an assay dependent concentration.|\nFunctionTranscriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I.\nSequence similaritiesBelongs to the bZIP family.\nContains 1 bZIP domain.\nCellular localizationCytoplasm. Cell membrane. Nucleus. Colocalizes with GABBR1 in hippocampal neuron dendritic membranes.\n- Information by UniProt\n- Activating transcription factor 4 antibody\n- ATF 4 antibody\n- ATF4 antibody\nSK-N-BE (Human neuroblastoma cell line) cells stained for ATF-4 (Green) using ab186284 at a 1/100 dilution (1 hour at RT) in ICC/IF.\nCells were fixed in 4% formaldehyde for 15 minutes at RT.\nSecondary Antibody: Goat Anti-Mouse ATTO 488 at 1:100 for 1 hour at RT.\nAnti-ATF-4 antibody [N360A/24] (ab186284) at 1/2000 dilution + Rat brain lysate at 15 µg\nGoat Anti-Mouse IgG: HRP at 1/2000 dilution\nDeveloped using the ECL technique.\nPredicted band size: 39 kDa\nExposure time: 5 minutes\nBlock: 5% Skimmed milk in 1X TBST.\nPrimary antibody incubated for 2 hours at RT.\nSecondary antibody incubated for 1 hour at RT.\nab186284 has not yet been referenced specifically in any publications.", "domain": "chemistry", "round": 3} +{"url": "http://iramis.cea.fr/en/Phocea/sujets_de_theses/index.php?domaine=Chemistry", "date": "2020-07-13T12:29:07Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-29/segments/1593657143365.88/warc/CC-MAIN-20200713100145-20200713130145-00560.warc.gz", "language_score": 0.9093942046165466, "token_count": 514, "dump": "CC-MAIN-2020-29", "global_id": "webtext-fineweb__CC-MAIN-2020-29__0__159570784", "lang": "en", "text": "Personal web page : http://iramis.cea.fr/nimbe/Phocea/Membres/Annuaire/index.php?uid=carrot\nLaboratory link : http://iramis.cea.fr/nimbe/licsen/\nBacteria are always present in our environment whether natural, industrial, medical-hospital ... Their presence is generally not harmful and can even be beneficial. Nevertheless, some of them being pathogenic, they can represent a real danger and be at the origin of public health problems. Controlling this microbial flora and its development still remain a challenge in different areas of applications.\nVery recent studies have shown that after only a few hours of adhesion to surfaces, bacteria were able to \"feel\" contact with the surface and to modify their proteome. Among the under or over expressed proteins, some are involved in the reactivity of bacteria to antimicrobials. These original data could explain some of the resistance phenomena observed today. What are the surfaces characteristics involved in these physiological evolutions? This is a crucial question to which it is now essential to provide elements of knowledge and answers, in order to help to the choice of surfaces and/or to the modifications of surfaces to be made (implants, medical environment, etc.).\nThe proposed thesis will therefore focus on the design of surfaces modified by polymers already studied previously (BRICAPAC project),1 showing a strong interaction with bacteria and a modular bacteriostatic effect. Here, we will try to better understand the impact of these interactions while changing the physicochemical parameters of the polymer layer. We will also graft other types of polymers with, for example, different charges, or to form amphiphilic or ampholytic copolymers. 3D surfaces will also be grafted (from nanoparticles) to study the impact of interactions in solution. Finally, nanostructured surfaces with defined patterns can be obtained from grafted polymers or nanoparticles, thanks to inkjet printing techniques. These new surfaces should make it possible to identify the factors behind the previously discussed adaptations (chemical composition, bacterial/surface adhesion interactions, mechanical stress, etc.). The proposed thesis will therefore concern the study of the reactivity of bacteria to antimicrobial agents, after adhesion to these surfaces. It will be carried out in close collaboration with a partner team specialized in bioadhesion and reactivity of immobilized bacteria (AgroParisTech INRA, UMR GMPA, Massy).", "domain": "chemistry", "round": 3} +{"url": "https://nalogometer.ru/radiocarbon-dating-age-1241.html", "date": "2021-05-10T08:36:18Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-21/segments/1620243989115.2/warc/CC-MAIN-20210510064318-20210510094318-00393.warc.gz", "language_score": 0.8784918189048767, "token_count": 403, "dump": "CC-MAIN-2021-21", "global_id": "webtext-fineweb__CC-MAIN-2021-21__0__153540816", "lang": "en", "text": "Radiocarbon dating age\nRadiocarbon dating marine organisms has added complications in Antarctica, because around the Antarctic continent old deep ocean currents up well.\nThese currents are contaminated with ‘old’ carbon, meaning that marine organisms alive today have a radio-carbon age of about 1200 years[5, 6].\nCharcoal, cloth, bone, or any other material that contains organic carbon can be dated using an accelerated mass spectrometer.\nIn conjunction with other creationist organizations, the Institute for Creation Research has assembled a team of researchers to challenge existing notions about the age of the Earth.\nThis paper will focus on how the radiocarbon dating method works, how it is used by scientists, and how creationists have interpreted the results.\nCarbon-14 is a radioactive isotope formed in the upper atmosphere.\nRates of radiocarbon production vary through time, in a quasi-periodic manner.\nIt is therefore necessary to distinguish between radiocarbon years ( against a chronology of calendar years.\nIn order to function properly, natural clocks need an irreversible process that occurs at a constant and known rate.Without this calibration, atmospheric fluctuations in C cause some radiocarbon dates to have an error up to 10%.Carbon isotopes are generally measured through the use of a machine called the accelerated mass spectrometer.The physics of decay and origin of carbon 14 for the radiocarbon dating1: Formation of Carbon-14.2: Decay of Carbon-14.3: The “equal” equation is for living organisms, and the unequal one is for non-living ones, in which the C-14 then decays (hence the 2).From: Wikimedia Commons We can indirectly date glacial sediments by looking at the organic materials above and below glacial sediments. Marine geological constraints for the grounding-line position of the Antarctic Ice Sheet on the southern Weddell Sea shelf at the Last Glacial Maximum.", "domain": "chemistry", "round": 3} +{"url": "https://analytik.news/en/papers/2017/59.html", "date": "2022-08-12T14:53:57Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571719.48/warc/CC-MAIN-20220812140019-20220812170019-00063.warc.gz", "language_score": 0.921969473361969, "token_count": 405, "dump": "CC-MAIN-2022-33", "global_id": "webtext-fineweb__CC-MAIN-2022-33__0__200711594", "lang": "en", "text": "qCell T auto - a fully automated QCM-D platform for surface interaction analysis\nThis study introduces the qCell T auto as a reliable and efficient tool for effortless long-time measurements that otherwise would have required the full hands-on attention of trained personnel. It carries all essential features of advanced Quartz Crystal Microbalance with Dissipation monitoring (QCM-D) technology. In addition it is equipped with superior fluidic and sample control, electronic log filing, sensor serial numbers combined with an in-built data base paving its way towards becoming a standardized method. More specifically, 3T analytik monitored the gradual build-up of two types of polyelectrolyte multilayers (PEMs). The combined measurement of frequency and dissi-pation/damping provided important information on the viscoelastic properties of the various PEMs as well as the film thickness.\nWhat is QCM-D and what can it do?\nQuartz Crystal Microbalance with Dissipation monitoring (QCM-D) is a surface-sensitive technique that is applied to detect adsorption of a material to an oscillating quartz sensor. The adsorption process is detected by means of monitoring changes in the sonsor's vibra-tional behaviour in real time. It can be imple-mented for studies of basically any surface adsorption phenomena including, but not limited to, molecular adsorption, bacterial adhesion or nanoparticle deposition, with new applications still being discovered. Negative shifts in the resonance frequency of the quartz sensor (Δf) is related to the amount of adsorbed mass with a sensitivity of about a billionth of a gram. The energy required to maintain constant vibrational amplitude is affected by dissipative energy losses induced by the adsorbed mass, also known as damping (half-bandwidth of the oscillation peak, ΔΓ). Both parameters are utilized to characterize the adsorbed material.", "domain": "chemistry", "round": 3} +{"url": "https://uphillathlete.com/forums/topic/fat-metabolism-question/", "date": "2024-04-20T22:46:13Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712296817688.24/warc/CC-MAIN-20240420214757-20240421004757-00605.warc.gz", "language_score": 0.9430167078971863, "token_count": 467, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__186483669", "lang": "en", "text": "Those are some very impressive accomplishments for and ‘old’ guy with a bum ticker! Good on you!\nBefore I dig into your questions here’s a disclaimer: I have only a layman’s understanding of Biochemistry and Physiology. These processes, that I am about to so casually discuss are incredibly complex. Far, far too complex to give them anything like a full explanation in a couple of paragraphs. Entire text books are devoted to this topic and several years of rigorous study are involved to understand it.\nWith that said: I can’t answer your question, especially as it relates to your medical condition with the stents/statins. You need to seek professional advice for that. I doubt you’ll find that level of understand and advice on any forum.\nYou’re correct that NADH is a product of glycolysis along with its ATP. However a more important principle product of glycolysis as that process relates to aerobic metabolism is pyruvate which can be converted to acetyl CoA in the mitochondria. Acetyl CoA is the precursor for aerobic metabolism which takes place inside the mitochondrial matrix. Aerobic metabolism includes the Krebs Cycle and the electron transport chain (where most of the ATP is released). This is how glycolysis can lead to aerobic metabolism when there is adequate aerobic capacity in the muscle cell.\nFat metabolism is known as lipolysis, of which a very crude and incomplete description is: Stored triglycerides are broken down and released into the blood as glycerin and free fatty acids. Those FFA are further converted, by way of particular enzymes, into Acetyl CoA. As in glycolysis, this acetyl CoA can then enter the mitochondrial matrix to undergo aerobic metabolism.\nBoth these processes contribute to the overall energy needs of the muscle cell. Slow twitch muscle has a much higher mitochondrial density so is able to aerobically produce ATP in great quantity from either fat (using lipolysis) or carbs (using glycolysis). Fast twitch muscle, because it has less mitochondria, has to rely more on anaerobic glycolysis for its ATP supply.\nI hope this helps,", "domain": "chemistry", "round": 3} +{"url": "http://www.lyst.com/bags/prada-saffiano-lux-tote-bag-edera-green/?ctx=4689", "date": "2013-05-24T18:14:24Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2013-20/segments/1368704943681/warc/CC-MAIN-20130516114903-00007-ip-10-60-113-184.ec2.internal.warc.gz", "language_score": 0.8353396058082581, "token_count": 474, "dump": "CC-MAIN-2013-20", "global_id": "webtext-fineweb__CC-MAIN-2013-20__0__24190957", "lang": "en", "text": "Prada Green Saffiano Lux Tote Bag\nExclusively at saks in copper. This classic shape in soft, stamped leather has goldtone hardware including a front logo embellishment. Double top handles, 5\" drop magnetic clip closure saffiano leather triangle logo with metal lettering gold-plated hardware one inside zip pocket one inside open pocket protective metal feet prada logo lining 15\"w x 10\"h x 7\"d made in italy.\nlime 1 |līm| noun (also quicklime) a white caustic alkaline substance consisting of calcium oxide, obtained by heating limestone. • (also slaked lime) a white alkaline substance consisting of calcium hydroxide, made by adding water to quicklime. • (in general use) any of a number of calcium compounds, esp. calcium hydroxide, used as an additive to soil or water. • archaic birdlime. verb [ trans. ] 1 treat (soil or water) with lime to reduce acidity and improve fertility or oxygen levels. • [often as adj. ] ( limed) give (wood) a bleached appearance by treating it with lime : limed oak dining furniture. 2 archaic catch (a bird) with birdlime. DERIVATIVES limy |ˈlīmē| adjective ( limier , limiest ). ORIGIN Old English līm, of Germanic origin; related to Dutch lijm, German Leim, also to loam . lime 2 noun 1 a rounded citrus fruit similar to a lemon but greener, smaller, and with a distinctive acid flavor. 2 (also lime tree) the evergreen citrus tree that produces this fruit, widely cultivated in warm climates. • Citrus aurantifolia, family Rutaceae. 3 a bright light green color like that of a lime : [as adj. ] day-glo orange, pink, or lime green. ORIGIN mid 17th cent.: from French, from modern Provençal limo, Spanish lima, from Arabic līma; compare with lemon . lime 3 (also lime tree) noun another term for linden , esp. the European linden. ORIGIN early 17th cent.: alteration of obsolete line, from Old English lind (see linden ).", "domain": "chemistry", "round": 3} +{"url": "https://m.scirp.org/papers/36583", "date": "2022-08-11T23:29:07Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571536.89/warc/CC-MAIN-20220811224716-20220812014716-00696.warc.gz", "language_score": 0.6539661884307861, "token_count": 2246, "dump": "CC-MAIN-2022-33", "global_id": "webtext-fineweb__CC-MAIN-2022-33__0__46972262", "lang": "en", "text": "MnZn-doped W-type barium cobalt ferrite powder composites of Ba(MnZn)xCo2(1-x)Fe16O27 (x = 0.1, 0.2, 0.3, 0.4, and 0.5) were prepared in a sol-gel process. The microwave absorbing properties of the composites in the range of 2 - 18 GHz and their electromagnetic loss mechanisms were studied. The results demonstrated that the synthesized Ba(MnZn)xCo2(1-x)Fe16O27 samples possess a W-type phase of the crystal structure with a hexagonal flaky shape in micro-morphology, and the samples exhibited a soft magnetic trait that enables improving their microwave absorption properties through suitable MnZn doping. For Ba(MnZn)0.4Co1.2Fe16O27 with a thickness of\n R. S. Meena, S. Bhattachrya and R. Chatterjee, “Complex Permittivity, Permeability and Microwave Absorbing Properties of (Mn2-xZnx) U-Type Hexaferrite,” Journal of Magnetism and Magnetic Materials, Vol. 322, No. 19, 2010, pp. 2908-2914. doi:10.1016/j.jmmm.2010.05.004\n A. Ghasemia, A. Hossienpourb, A. Morisako, A. Saatchi and M. Salehi, “Electromagnetic Properties and Microwave Absorbing Characteristics of Doped Barium Hexaferrite,” Journal of Magnetism and Magnetic Materials, Vol. 302, No. 2, 2006, pp. 429-435. doi:10.1016/j.jmmm.2005.10.006\n R. C. Pullar, “Hexagonal Ferrites: A Review of the Synthesis, Properties and Applications of Hexaferrite Ceramics,” Progress in Materials Science, Vol. 57, No. 7, 2012, pp. 1191-1334.\n A. Ghasemi, A. Hossienpourb, A. Morisako and X. Liu, “Investigation of the Microwave Absorptive Behavior of Doped Barium Ferrites,” Materials & Design, Vol. 29, No. 1, 2008, pp. 112-117.\n M. H. Shams, S. M. A. Salehi and A. Ghasemi, “Electromagnetic Wave Absorption Characteristics of Mg-Ti Substituted Ba-Hexaferrite,” Materials Letters, Vol. 62, No. 10-11, 2008, pp. 1731-1733. doi:10.1016/j.matlet.2007.09.073\n S. Sugimoto, K. Haga, T. Kagotani and K. Inomata, “Microwave Absorption Properties of Ba M-Type Ferrite Prepared by a Modified Coprecipitation Method,” Journal of Magnetism and Magnetic Materials, Vol. 290-291, 2005, pp. 1188-1191. doi:10.1016/j.jmmm.2004.11.381\n A. Ghasemi, X. Liu and A. Morisako, “Magnetic and Microwave Absorption Properties of\n S. Choopani, N. Keyhan, A. Ghasemi, A. Sharbati and R. Alam, “Structural, Magnetic and Microwave Absorption Characteristics of BaCoxMnxTi2xFe12-4xO19,” Materials Chemistry and Physics, Vol. 113, No. 2-3, 2009, pp. 717-720. doi:10.1016/j.matchemphys.2008.07.130\n Y. Kim and S. Kim, “Magnetic and Microwave Absorbing Properties of Ti and Co Substituted M-Hexaferrites in Ka-Band Frequencies (26.5 40 GHz),” Journal of Electroceramics, Vol. 24, No. 4, 2010, pp. 314-318. doi:10.1007/s10832-009-9575-x\n M. Matsumoto and Y. Miyata, “A Gigahertz-Range Electromagnetic Wave Absorber with Wide Bandwidth Made of Hexagonal Ferrite,” Journal of Applied Physics, Vol. 79, No. 8, 1996, pp. 5486-5488. doi:10.1063/1.362284\n Z. F. Zi, J. M. Dai,Q. C. Liu, H. Y. Liu, X. B. Zhu and Y. P. Sun, “Magnetic and Microwave Absorption Properties of W-Type Ba(ZnxCo1-x)2Fe16O27 Hexaferrite Platelets,” Journal of Applied Physics, Vol. 109, No. 7, 2011, Article ID: 07E536-1-3.\n M. R. Meshram, N. K. Agrawal, B. Sinhaa and P. S. Misra, “Characterization of M-Type Barium Hexagonal Ferrite-Based Wide Band Microwave Absorber,” Journal of Magnetism and Magnetic Materials, Vol. 271, No. 2-3, 2004, pp. 207-214. doi:10.1016/j.jmmm.2003.09.045\n R. S. Meena1, S. Bhattachrya and R. Chatterjee, “Complex Permittivity, Permeability and Microwave Absorbing Studies of (Co2-xMnx) U-Type Hexaferrite for XBand (8.2 12.4 GHz) Frequencies,” Materials Science and Engineering: B, Vol. 171, No. 1-3, 2010, pp. 133138.\n Y. Nie, H. H. He, Z. K. Feng, X. C. Zhang and X. M. Cheng, “Microwave Characterization of (Co, Zn)2 W Barium Hexagonal Ferrite Particles,” Journal of Magnetism and Magnetic Materials, Vol. 303, No. 2, 2006, pp. e423e427.\n F. Tabatabaie, M. H. Fathi, A. Saatchi and A. Ghasemi, “Microwave Absorption Properties of Mnand Ti-Doped Strontium Hexaferrite,” Journal of Alloys and Compounds, Vol. 470, No. 1-2, 2009, pp. 332-335. doi:10.1016/j.jallcom.2008.02.094\n S. Choopani, N. Keyhan, A.Ghasemi, A. Sharbathi, I. Maghsoudi and M. Eghbali, “Static and Dynamic Magnetic Characteristics of BaCo0.5Mn0.5Ti1.0Fe10O19,” Journal of Magnetism and Magnetic Materials, Vol. 321, No. 13, 2009, pp. 1996-2000. doi:10.1016/j.jmmm.2008.12.030\n S. P. Gairola, V. Verma, A. Singh , L. P. Purohit and R. K. Kotnala, “Modified Composition of Barium Ferrite to Act as a Microwave Absorber in X-Band Frequencies,” Solid State Communications, Vol. 150, No. 3-4, 2010, pp. 147151. doi:10.1016/j.ssc.2009.10.011\n T. Kagotani, D. Fujiwara, S. Sugimoto, K. Inomata and M. Homma, “Enhancement of GHz Electromagnetic Wave Absorption Characteristics in Aligned M-Type Barium Ferrite Ba1-xLaxZnxFe12-x-y(Me0.5Mn0.5)yO19 (x = 0.0 0.5; y = 1.0 3.0; Me: Zr, Sn) by Metal Substitution,” Journal of Magnetism and Magnetic Materials, Vol. 272, 2004, pp. e1813-e1815.\n X. Huang, J. Zhang, H. Wang, S. Yan, L. Wang and Q. Zhang, “Er3+-Substituted W-Type Barium Ferrite: Preparation and Electromagnetic Properties,” Journal of Rare Earths, Vol. 28, No. 6, 2010, pp. 940-943. doi:10.1016/S1002-0721(09)60211-8\n A. Oikonomou, T. Giannakopoulou and G. Litsardakis, “Design, Fabrication and Characterization of Hexagonal Ferrite Multi-Layer Microwave Absorber,” Journal of Magnetism and Magnetic Materials, Vol. 316, No. 2, 2007, pp. e827-e830. doi:10.1016/j.jmmm.2007.03.114\n P. Singh, V. K. Babbar, A. Razdan, R. K. Puri and T. C. Goel, “Complex Permittivity, Permeability, and x-Band Microwave Absorption of CaCoTi Ferrite Composites,” Journal of Applied Physics, Vol. 87, No. 9, 2000, pp. 4362-4365. doi:10.1063/1.373079", "domain": "chemistry", "round": 3} +{"url": "https://bioisi.pt/a-syk-shc1-pathway-regulates-the-amount-of-cftr-in-the-plasma-membrane/", "date": "2024-02-28T10:41:50Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707947474700.89/warc/CC-MAIN-20240228080245-20240228110245-00680.warc.gz", "language_score": 0.924489438533783, "token_count": 310, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__81838747", "lang": "en", "text": "Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene cause the recessive genetic disease cystic fibrosis, where the chloride transport across the apical membrane of epithelial cells mediated by the CFTR protein is impaired. CFTR protein trafficking to the plasma membrane (PM) is the result of a complex interplay between the secretory and membrane recycling pathways that control the number of channels present at the membrane. In addition, the ion transport activity of CFTR at the PM is modulated through post-translational protein modifications. Previously we described that spleen tyrosine kinase (SYK) phosphorylates a specific tyrosine residue in the nucleotide-binding domain 1 domain and this modification can regulate the PM abundance of CFTR. Here we identified the underlying biochemical mechanism using peptide pull-down assays followed by mass spectrometry. We identified in bronchial epithelial cells that the adaptor protein SHC1 recognizes tyrosine-phosphorylated CFTR through its phosphotyrosine-binding domain and that the formation of a complex between SHC1 and CFTR is induced at the PM in the presence of activated SYK. The depletion of endogenous SHC1 expression was sufficient to promote an increase in CFTR at the PM of these cells. The results identify a SYK/SHC1 pathway that regulates the PM levels of CFTR channels, contributing to a better understanding of how CFTR-mediated chloride secretion is regulated.", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/glutathione-peroxidase-1-antibody-ab59546.html?productWallTab=Abreviews", "date": "2019-10-20T01:14:12Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-43/segments/1570986700560.62/warc/CC-MAIN-20191020001515-20191020025015-00331.warc.gz", "language_score": 0.8010058403015137, "token_count": 1020, "dump": "CC-MAIN-2019-43", "global_id": "webtext-fineweb__CC-MAIN-2019-43__0__122747748", "lang": "en", "text": "Product nameAnti-Glutathione Peroxidase 1 antibody\nSee all Glutathione Peroxidase 1 primary antibodies\nDescriptionRabbit polyclonal to Glutathione Peroxidase 1\nTested applicationsSuitable for: ICC/IF, WB, ELISA, IHC-Fr, IHC-Pmore details\nSpecies reactivityReacts with: Rat, Human\nPredicted to work with: Mouse, Cow, Pig, Chimpanzee, Macaque monkey, Orangutan\n- Human brain tissue cytoplasmic lysate Human or rat glial cells Human or rat neurons Stains human and rat glial cells very strongly and shows lesser staining in neurons.\nGeneral notesStore working volume at +4°C.\nStorage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.\nStorage bufferPreservative: 0.02% Thimerosal (merthiolate)\nConstituent: Whole serum\nOur Abpromise guarantee covers the use of ab59546 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\n|ICC/IF||1/20 - 1/100.|\n|WB||1/1000 - 1/4000. Detects a band of approximately 22 kDa.|\n|ELISA||1/1000 - 1/4000.|\n|IHC-Fr||Use at an assay dependent concentration.|\n|IHC-P||Use at an assay dependent concentration.|\nFunctionProtects the hemoglobin in erythrocytes from oxidative breakdown.\nSequence similaritiesBelongs to the glutathione peroxidase family.\n- Information by UniProt\n- AL033363 antibody\n- Cellular glutathione peroxidase antibody\n- Glutathione peroxidase 1 antibody\nAnti-Glutathione Peroxidase 1 antibody (ab59546) at 1/2000 dilution + Liver (Mouse) Tissue Lysate at 10 µg\nGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilution\nObserved band size: 22 kDa why is the actual band size different from the predicted?\nAdditional bands at: 30 kDa. We are unsure as to the identity of these extra bands.\nICC/IF image of ab59546 stained HeLa cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab59546, 1µg/ml) overnight at +4°C. The secondary antibody (green) was Alexa Fluor® 488 goat anti-rabbit IgG (H+L) used at a 1/1000 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.\nIHC image of ab59546 staining in human normal lymphoid formalin fixed paraffin embedded tissue section, performed on a Leica BondTM system using the standard protocol F. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. The section was then incubated with ab59546, 5µg/ml, for 15 mins at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.\nFor other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, primary antibody concentration and antibody incubation times.\nThis product has been referenced in:\n- Gille T et al. Intermittent Hypoxia Increases the Severity of Bleomycin-Induced Lung Injury in Mice. Oxid Med Cell Longev 2018:1240192 (2018). Read more (PubMed: 29725493) »\n- Shin EJ et al. Genetic overexpression of glutathione peroxidase-1 attenuates microcystin-leucine-arginine-induced memory impairment in mice. Neurochem Int 118:152-165 (2018). Read more (PubMed: 29908255) »", "domain": "chemistry", "round": 3} +{"url": "https://ntnuopen.ntnu.no/ntnu-xmlui/handle/11250/2623031", "date": "2022-05-16T06:36:01Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-21/segments/1652662509990.19/warc/CC-MAIN-20220516041337-20220516071337-00528.warc.gz", "language_score": 0.8869984745979309, "token_count": 372, "dump": "CC-MAIN-2022-21", "global_id": "webtext-fineweb__CC-MAIN-2022-21__0__209789098", "lang": "en", "text": "Multi-modal characterization of vasculature and nanoparticle accumulation in five tumor xenograft models\nJournal article, Peer reviewed\nMetadataVis full innførsel\nOriginalversjonJournal of Controlled Release. 2018, 279 292-305. 10.1016/j.jconrel.2018.04.026\nPreclinical research has demonstrated that nanoparticles and macromolecules can accumulate in solid tumors due to the enhanced permeability and retention effect. However, drug loaded nanoparticles often fail to show increased efficacy in clinical trials. A better understanding of how tumor heterogeneity affects nanoparticle accumulation could help elucidate this discrepancy and help in patient selection for nanomedicine therapy. Here we studied five human tumor models with varying morphology and evaluated the accumulation of 100 nm polystyrene nanoparticles. Each tumor model was characterized in vivo using micro-computed tomography, contrast-enhanced ultrasound and diffusion-weighted and dynamic contrast-enhanced magnetic resonance imaging. Ex vivo, the tumors were sectioned for both fluorescence microscopy and histology. Nanoparticle uptake and distribution in the tumors were generally heterogeneous. Density of functional blood vessels measured by fluorescence microscopy correlated significantly (p = 0.0056) with nanoparticle accumulation and interestingly, inflow of microbubbles measured with ultrasound also showed a moderate but significant (p = 0.041) correlation with nanoparticle accumulation indicating that both amount of vessels and vessel morphology and perfusion predict nanoparticle accumulation. This indicates that blood vessel characterization using contrast-enhanced ultrasound imaging or other methods could be valuable for patient stratification for treatment with nanomedicines.", "domain": "chemistry", "round": 3} +{"url": "http://slideplayer.com/slide/3354106/", "date": "2019-03-24T16:10:29Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-13/segments/1552912203462.50/warc/CC-MAIN-20190324145706-20190324171706-00000.warc.gz", "language_score": 0.8626987338066101, "token_count": 812, "dump": "CC-MAIN-2019-13", "global_id": "webtext-fineweb__CC-MAIN-2019-13__0__8148475", "lang": "en", "text": "Presentation on theme: \"A SYNTHETIC GENE- METABOLIC OSCILLATOR Reviewed by Fei Chen.\"— Presentation transcript:\nA SYNTHETIC GENE- METABOLIC OSCILLATOR Reviewed by Fei Chen\nBackground Autonomous oscillations in gene expression are found in metabolic, cardiac, and neuronal systems. Such oscillators have important biological roles, as well as very interesting dynamics. Integration of oscillatory regulation with metabolism is a key aspect of natural oscillators. Replication of such oscillatory networks could be very useful for a range of synthetic biology applications.\nSystem Goals Main goal: Construction of an metabolically controlled oscillatory circuit. Conceptual Design: Two inter-converting metabolite pools, catalyzed by two enzymes. Uses metabolic flux as a control factor in system- wide oscillation.\nOscillatory Dynamics Two metabolite pools (M1, M2), catalyzed by two enzymes (E1, E2). E1 negatively regulated by M2, and E2 positively regulated by M2. If input flux is low, M2 does not accumulate sufficiently fast to cause a large swing in gene expression; steady state can be reached. Metabolic physiology —› gene expression cycle.\nImplementation The system uses the acetate pathway in E. Coli. Acetyl CoA is M1, Acetyl Phosphate (AcP) is M2. Acetyl CoA is converted to AcP by Phosphate Acetyltransferase (Pta) (E1). Enzyme acetyl-CoA Synthase (AcS) is induced in the presence of Acetate. (E2) AcP in M2 is the signaling molecule. Activates glnAp2 promoter. glnAp2 controls expression of AcS, also produces lacI repressor. This represses the Pta gene. Obtain same network as our model.\nCharacterization Characterization via GFP ligated downstream of a plasmid born LacI-repressible tac promoter. Acs, LacI, Pta, and the GFP were all fused with a degradation tag. Oscillation behavior was shown to be insensitive to degradation of GFP. GFP reporter is indicative of the dynamics of the system. Characterized system parameters with computational models. Verified computational model through system influx variation.\nResults: Flourescence Microscopy Periodic oscillations observed Period: 45 min ± 10 min Amplitude of oscillations vary Daughter cells show uneven fluorescence. Comparison between sibling cells show skipped or delayed peaks.\nResults: Flux Sensitive Oscillation Flux directly correlated to oscillation period. High levels of external acetate suppressed oscillation.\nDiscussion Successful demonstration of metabolic regulation of oscillatory circuit. Oscillation is generated by input of metabolic flux. (Acetyl CoA). High concentrations of acetate suppresses oscillation. Maintains concentration of acetyl phosphate higher than dynamic range of promoter response. Accumulation of acetate produced by cell will move cell out of oscillatory cycle. Intrinsic noise could explain observed experimental variations. (Amplitude of Oscillator) Uncorrelated with cell division, suggests noise is entirely from gene expression.\nReferences: All figures and pictures taken from: Fung E, Wong WW, Suen JK, Bulter T, Lee SG, and Liao JC. A synthetic gene-metabolic oscillator. Nature 2005 May 5; 435(7038) 118-22. doi:10.1038/nature03508 pmid:15875027. PubMed HubMed [metabolator]Fung E, Wong WW, Suen JK, Bulter T, Lee SG, and Liao JC. A synthetic gene-metabolic oscillator. Nature 2005 May 5; 435(7038) 118-22. PubMedHubMed", "domain": "chemistry", "round": 3} +{"url": "https://eprints.nmlindia.org/8666/", "date": "2023-03-23T17:08:44Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-14/segments/1679296945182.12/warc/CC-MAIN-20230323163125-20230323193125-00117.warc.gz", "language_score": 0.8482004404067993, "token_count": 407, "dump": "CC-MAIN-2023-14", "global_id": "webtext-fineweb__CC-MAIN-2023-14__0__291275673", "lang": "en", "text": "Chatterjea, A B and Nijhawan, B R (1949) Iron production in Low Shaft Furnace Pilot Plant with Non-Coking Coals (National Metallurgical Laboratory). Other (TMP). CSIR-NML, Jamshedpur, Jamshedpur.\n|PDF (Iron Production with Non-Coking Coals in Low Shaft Furnace Pilot Plant at The National Metallurgy Laboratory) - Published Version |\nRestricted to NML users only. Others may use ->\nDevelopments of engineering and scientific technology have brought in their wake revolutionary changes in the production of iron and steel. The convectional blast furnace which is sine-que-non for economic iron production requires high grade raw-materials such as hard but porous metallurgical coke and either lumpy iron ore or sintered iron ore. The reserves of high grade raw materials are gradually decreasing all over the World and alternative methods of iron-making are being actively investigated. While India has plentiful reserves of rich iron ores, such processes have special significance in India due to poor reserves of coking coal and their occurrences over small geographical region. Among such alternative processes, the Low Shaft Furnace Process has got several attractive heights which widens the choice of raw materials and allows utilization of furnace gas of high thermal value.\n|Item Type:||Project Reports (Other (TMP))|\n|Uncontrolled Keywords:||Iron Production,Low Shaft Furnace Pilot Plant, non-coking coals, high thermal value|\n|Divisions:||Information Management and Dissemination Centre|\n|Deposited By:||Dr Mita Tarafder|\n|Deposited On:||15 Feb 2022 11:58|\n|Last Modified:||20 May 2022 16:42|\nRepository Staff Only: item control page", "domain": "chemistry", "round": 3} +{"url": "https://saemobilus.sae.org/content/2019-01-2105/", "date": "2020-08-08T06:27:44Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-34/segments/1596439737289.75/warc/CC-MAIN-20200808051116-20200808081116-00306.warc.gz", "language_score": 0.6784336566925049, "token_count": 2310, "dump": "CC-MAIN-2020-34", "global_id": "webtext-fineweb__CC-MAIN-2020-34__0__14908342", "lang": "en", "text": "This content is not included in your SAE MOBILUS subscription, or you are not logged in.\nInfluence of Amount of Phenolic Resin on the Tribological Performance of Environment-Friendly Friction Materials\nISSN: 0148-7191, e-ISSN: 2688-3627\nPublished September 15, 2019 by SAE International in United States\nThis content contains downloadable datasetsAnnotation ability available\nThe binder in friction materials (FMs) plays a very crucial role which binds all the ingredients firmly so that they can function the way they were supposed to do. The type and amount of binder, both are very critical for manipulating the desired performance properties, which mainly include friction and its sensitivity towards operating parameters, wear resistance, counter-face friendliness, noise, vibration etc. Although a lot is reported on the influence of types of resins on tribo-performance of FMs, hardly any paper pertains to paint this on a bigger canvas with more detailed understanding of the amount of resin in FMs on the performance properties.\nThe present study addresses these aspects by developing brake-pads with identical composition but varying in amount (wt. %) of straight phenolic resins (6, 8, 10 and 12) by compensating the difference with barite, a space filler. The ingredients did not contain asbestos, Copper, Zinc, etc. and hence were environment friendly. Tribological performance of the composites was evaluated on a full-scale inertia brake dynamometer following JASO C406 test schedule. With increase in the resin contents, most of the performance properties showed improvement. The performance ranking of pads was done using ‘Multiple Objective Optimizations based on Ratio Analysis (MOORA)’ method based on several conflicting criterions. Worn surface topography of pads was investigated using SEM technique to understand the underlying wear mechanisms.\nCitationKalel, N., Bijwe, J., and Darpe, A., \"Influence of Amount of Phenolic Resin on the Tribological Performance of Environment-Friendly Friction Materials,\" SAE Technical Paper 2019-01-2105, 2019, https://doi.org/10.4271/2019-01-2105.\nData Sets - Support Documents\n|[Unnamed Dataset 1]|\n|[Unnamed Dataset 2]|\n|[Unnamed Dataset 3]|\n|[Unnamed Dataset 4]|\n|[Unnamed Dataset 5]|\n- Bijwe, J. , “Composites as Friction Materials: Recent Developments in Non-Asbestos Fiber Reinforced Friction Materials: A Review,” Polym. Compos. 18:378-396, 1997, doi:10.1002/pc.10289.\n- Chan, D. and Stachowiak, G. W. , “Review of Automotive Brake Friction Materials,” Proc. Inst. Mech. Eng. Part D J. Automob. Eng. 218:953-966, 2004, doi:10.1243/0954407041856773.\n- Breuer, K. H. B. B. , Brake Technology Handbook (Warrendale, Pennsylvania, USA: SAE International, 2008).\n- Blau, P. J. , “Compositions, Functions, and Testing of Friction Brake Materials and Their Additives,” Energy. 27:9-38, 2001. http://dx.doi.org/10.2172/788356.\n- Kim, S. J. and Jang, H. , “Friction and Wear of Friction Materials Containing Two Different Phenolic Resins Reinforced with Aramid Pulp,” Tribol. Int. 33:477-484, 2000, doi:10.1016/S0301-679X(00)00087-6.\n- Jacko, M. G., Ducharme, R. T., and Somers, J. H. , “Brake and Clutch Emissions Generated During Vehicle Operation,” SAE Technical Paper 730548, 1973, doi:10.4271/730548.\n- Lu, Y. , “A Combinatorial Approach for Automotive Friction Materials: Effects of Ingredients on Friction Performance,” Compos. Sci. Technol. 66:591-598, 2006, doi:10.1016/j.compscitech.2005.05.032.\n- Pilato, L. , “Phenolic Resins: A Century of Progress,” 2010. doi:10.1007/978-3-642-04714-5.\n- Fei, J., Li, H. J., Fu, Y. W., Qi, L. H., and Zhang, Y. L. , “Effect of Phenolic Resin Content on Performance of Carbon Fiber Reinforced Paper-Based Friction Material,” Wear. 269:534-540, 2010, doi:10.1016/j.wear.2010.05.008.\n- Bijwe, N. J. and Satapathy, B. K. , “Influence of Amount of Resin on Fade and Recovery Behavior of Non-Asbestos Organic (NAO) Friction Materials,” Trans. Indian Inst. Met. 57:335-344, 2004, doi:10.1007/s11249-006-9055-2.\n- Kim, Y. C., Cho, M. H., Kim, S. J., and Jang, H. , “The Effect of Phenolic Resin, Potassium Titanate, and CNSL on the Tribological Properties of Brake Friction Materials,” Wear. 264:204-210, 2008, doi:10.1016/j.wear.2007.03.004.\n- Bijwe, N. J. , “NBR-Modified Resin in Fade and Recovery Module in Non-Asbestos Organic (NAO) Friction Materials,” Tribol. Lett. 27:189-196, 2007, doi:10.1007/s11249-007-9225-x.\n- Bijwe, N. J., Majumdar, N., and Satapathy, B. K. , “Influence of Modified Phenolic Resins on the Fade and Recovery Behavior of Friction Materials,” Wear. 259:1068-1078, 2005, doi:10.1016/j.wear.2005.01.011.\n- Hong, U. S., Jung, S. L., Cho, K. H., Cho, M. H. et al. , “Wear Mechanism of Multiphase Friction Materials with Different Phenolic Resin Matrices,” Wear. 266:739-744, 2009, doi:10.1016/j.wear.2008.08.008.\n- Dureja, N., Bijwe, J., and Gurunath, P. V. , “Role of Type and Amount of Resin on Performance Behavior of Non-Asbestos Organic (NAO) Friction Materials,” J. Reinf. Plast. Compos. 28:489-497, 2009, doi:10.1177/0731684407086588.\n- Wu, Y., Zeng, M., Xu, Q., Hou, S. et al. , “Effects of Glass-to-Rubber Transition of Thermosetting Resin Matrix on the Friction and Wear Properties of Friction Materials,” Tribol. Int. 54:51-57, 2012, doi:10.1016/J.TRIBOINT.2012.05.018.\n- Rhee, S. K. , “Wear Mechanisms at Low-Temperatures for Metal-Reinforced Phenolic Resins,” Wear. 23:261-263, 1973, doi:10.1016/0043-1648(73)90090-2.\n- Kumar, M. and Bijwe, J. , “NAO Friction Materials with Various Metal Powders: Tribological Evaluation on Full-Scale Inertia Dynamometer,” Wear. 269:826-837, 2010, doi:10.1016/j.wear.2010.08.011.\n- Kumar, M. and Bijwe, J. , “Role of Different Metallic Fillers in Non-Asbestos Organic (NAO) Friction Composites for Controlling Sensitivity of Coefficient of Friction to Load and Speed,” Tribol. Int. 43:965-974, 2010, doi:10.1016/j.triboint.2009.12.062.\n- Aranganathan, N., Mahale, V., and Bijwe, J. , “Effects of Aramid Fiber Concentration on the Friction and Wear Characteristics of Non-Asbestos Organic Friction Composites Using Standardized Braking Tests,” Wear. 354-355:69-77, 2016, doi:10.1016/j.wear.2016.03.002.\n- Aranganathan, N. and Bijwe, J. , “Development of Copper-Free Eco-Friendly Brake-Friction Material Using Novel Ingredients,” Wear. 352-353:79-91, 2016, doi:10.1016/j.wear.2016.01.023.\n- Mahale, V., Bijwe, J., and Sinha, S. , “Influence of Nano-Potassium Titanate Particles on the Performance of NAO Brake-Pads,” Wear. 376-377:727-737, 2017, doi:10.1016/j.wear.2016.11.034.\n- Brauers, W. K. M. and Zavadskas, E. K. , “The MOORA Method and Its Application to Privatization in a Transition Economy,” Control Cybern. 35:445-469, 2006.\n- Chakraborty, S. , “Applications of the MOORA Method for Decision Making in Manufacturing Environment,” Int. J. Adv. Manuf. Technol. 54:1155-1166, 2011, doi:10.1007/s00170-010-2972-0.\n- Mahale, V., Bijwe, J., and Sinha, S. , “Application and Comparative Study of New Optimization Method for Performance Ranking of Friction Materials,” Proc. Inst. Mech. Eng. Part J J. Eng. Tribol. 232:143-154, 2018, doi:10.1177/1350650117708479.", "domain": "chemistry", "round": 3} +{"url": "http://www.fluidjournalonline.com/?iid=43792&startpage=page0000113&xml=Fluid_Fertilizer_new", "date": "2017-08-17T07:38:18Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-34/segments/1502886102993.24/warc/CC-MAIN-20170817073135-20170817093135-00197.warc.gz", "language_score": 0.9118075966835022, "token_count": 679, "dump": "CC-MAIN-2017-34", "global_id": "webtext-fineweb__CC-MAIN-2017-34__0__282126485", "lang": "en", "text": "Sign up for email alerts of new Fluid Journal issues!\nFluid Journal : Fluid Journal 1993-1995\n1 Fluid Journal Spring 1995 Drs. Patrick H. Brown, Louise Ferguson, and Geno Picchioni Boron Boosts Pistachio Yields California researchers find foliar applications are most effective after three- year trials. Timing of application is critical. Table 1. Effect of application date of foliar boron (5 pounds of Solubor/100 gals) on pistachio yield and leaf boron, Brown et al., University of California. Yield Leaf Boron Application Date Growth Stage lbs (July) micro-g February 28 Late dormant 64 188 March 19 Early bud break 52 188 April 3 Flowering 54 187 April 17 Leafing out 51 256 May 8 Fully leafed out 52 468 02510 246 8 lbs/100 gals oz/tree Rate of application 124 122 120 118 116 114 112 110 108 106 104 102 100 98 Foliar Applied Soil Applied Yield - lbs/tree Figure 1. Influence of boron (soil or foliar) on pistachio yield, three-year average, Brown, et al., University of California. Summary: Boron supplementation applied on pistachio trees in the late dormant stage increases germination, reduces blanking as well as non-splits, and, consequently, increases yield. Soil applications of boron are effective in raising leaf boron levels, but are not as effective as foliar sprays at increasing yield. Recommended rates of boron application most effective in raising yields are between 2 and 5 lbs Solubor/ 100 gals. Timing of foliar applications of boron is critical. Late dormant sprays (just prior to bud swell through to 20 percent bud break) are the most effective. Enhanced yield response to boron sprays may decrease yield in the following off-year effectively enhancing alternate bearing. At the site used here, boron sprays produced a net yield increase of approximately 20 percent over two veers. Based on the results of this work, it is suggested that pistachio growers provide supplemental boron sprays at the rate of 2 to 5 lbs Solubor/100 gals during the late dormant or early bud break stage. These recommendations are based on research in two soil types in plants with average tissue summer boron levels of 150 to 190 ppm. The validity of these recommendations in different soils and environmental conditions is being assessed. Boron deficiency occurs widely in the fruit growing regions of California. It is a limiting element in many pistachio growing regions of the central valleys. Boron deficiency results in characteristic leaf symptoms that can be alleviated with the additions of boron fertilizer. Boron long has been recognized as an essential element for plant growth. However, its role and mode of action are unknown. Boron has been reported to be involved in such diverse processes as nucleic acid metabolism, cell division, sugar biosynthesis and translocation. and membrane functions. The role boron plays in the flowering and fruiting process, however, is unclear. There is an immediate need, therefore, to understand how boron moves through the soil and plant, and\nFluid Journal 1996-1998", "domain": "chemistry", "round": 3} +{"url": "http://en.dsqhcnh.cn/product/572.html", "date": "2021-10-16T12:46:41Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-43/segments/1634323584567.81/warc/CC-MAIN-20211016105157-20211016135157-00514.warc.gz", "language_score": 0.9234384894371033, "token_count": 252, "dump": "CC-MAIN-2021-43", "global_id": "webtext-fineweb__CC-MAIN-2021-43__0__270095799", "lang": "en", "text": "Olivine, the most important rock-forming mineral in the upper mantle, is a silicate of magnesium and iron. The main component is iron or magnesium, and it also contains elements such as manganese, nickel, and cobalt. The crystals are granular and are dispersed particles or granular aggregates in the rock. Belongs to island silicate. Olivine metamorphism can form serpentine or magnesite, which can be used as a refractory material.\nGem-grade olivine is mainly divided into strong yellow-green peridot, golden-green peridot, yellow-green peridot, strong green peridot (also called evening emerald or western emerald, evening primrose emerald) and sky gemstone (produced in Very rare among meteorites). High-quality peridot is transparent olive-green or yellow-green, and its clear and beautiful color is very pleasing to the eye, symbolizing peace, happiness, tranquility and other good wishes. In ancient times, wars between some tribes often expressed peace by giving each other olivine. In some temples in Jerusalem, there are still peridotes that were inlaid thousands of years ago.", "domain": "chemistry", "round": 3} +{"url": "https://www.hugendubel.de/de/buch_gebunden/carbon_nanotubes-6732518-produkt-details.html?internal-rewrite=true", "date": "2020-05-28T08:01:18Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-24/segments/1590347398233.32/warc/CC-MAIN-20200528061845-20200528091845-00104.warc.gz", "language_score": 0.8468791246414185, "token_count": 911, "dump": "CC-MAIN-2020-24", "global_id": "webtext-fineweb__CC-MAIN-2020-24__0__12185270", "lang": "en", "text": "Titel: Carbon Nanotubes\nAdvanced Topics in the Synthesis, Structure, Properties and Applications.\n250 schw. -w. Abbildungen.\nHerausgegeben von Ado Jorio, Mildred S. Dresselhaus\n24. Januar 2008 - gebunden - XXIV\nThe carbon nanotubes field has evolved substantially since the publication of the bestseller Carbon Nanotubes: Synthesis, Structure, Properties and Applications . The present volume builds on the generic aspects of the aforementioned book, which emphasizes the fundamentals, with the new volume emphasizing areas that have grown rapidly since the first volume, guiding future directions where research is needed and highlighting applications. The volume also includes an emphasis on areas like graphene, other carbon-like and other tube-like materials because these fields are likely to affect and influence developments in nanotubes in the next 5 years.\nUltrafast Spectroscopy of Carbon Nanotubes.- Rayleigh Scattering Spectroscopy.- New Techniques for Carbon-Nanotube Study and Characterization.- High Magnetic Field Phenomena in Carbon Nanotubes.- Carbon-Nanotube Optoelectronics.- Electrical Transport in Single-Wall Carbon Nanotubes.- Double-Wall Carbon Nanotubes.- Doped Carbon Nanotubes: Synthesis, Characterization and Applications.- Electrochemistry of Carbon Nanotubes.- Single-Wall Carbon Nanohorns and Nanocones.- to the Important and Exciting Aspects of Carbon-Nanotube Science and Technology.- Inorganic Nanotubes and Fullerene-Like Structures (IF).- Electron and Phonon Properties of Graphene: Their Relationship with Carbon Nanotubes.- Potential Applications of Carbon Nanotubes.- Carbon-Nanotube Metrology.- Carbon Nanotube Synthesis and Organization.- Mechanical Properties, Thermal Stability and Heat Transport in Carbon Nanotubes.- Quasiparticle and Excitonic Effects in the Optical Response of Nanotubes and Nanoribbons.- Role of the Aharonov-Bohm Phase in the Optical Properties of Carbon Nanotubes.- Excitonic States and Resonance Raman Spectroscopy of Single-Wall Carbon Nanotubes.- Photoluminescence: Science and Applications.\nA. Jorio received his Ph.D in Physics from the Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil, in 1999. He is a Professor of Physics at UFMG since 2002, and is a conseillor of the Brazilian National Institute of Metrology (INMETRO) since 2006. He worked previously in various reserach institutes like the Institute Laue-Langevin (ILL), Grenoble, France and the Massachusetts Institute of Technology (MIT), Cambridge, USA, and has been awarded with the PROFIX and Productivity grants from Brazil. He co-authored with Profs. Dresselhaus a book of the applications of group theory to condensed matter physics. His research activities cover the optical properties of nanomaterials and the fundamental aspects of nanometrology.\nM. S. Dresselhaus received her Ph.D. in Physics from the University of Chicago, in 1958. She is an Institute Professor at the Massachusetts Institute of Technology and has been active in many aspects of condensed matter and materials research with particular emphasis on carbon science including nanostructures such as carbon nanotubes and fullerenes, but also including nanowires and other nanomaterials systems relevant to low dimensional thermoelectricity. She is the recipient of the National Medal of Science in the US and 24 honorary degrees worldwide. She served as the Director of the Office of Science at the DOE in 2000--2001 and co-chaired a DOE report \"Basic Research Needs for the Hydrogen Economy (2003).\nG. Dresselhaus received his Ph.D. in physics from the University of California in 1955. He was a faculty member at the University of Chicago, and on the physics faculty at Cornell University before joining the MIT Lincoln Laboratory in 1960 as a staff member. In 1976 he assumed his current senior staff position at the MIT Francis Bitter Magnet Laboratory. His area of interest is the electronic structure of nanomaterials and he has co-authored with M.S. Dresselhaus several books on fullerenes, nanowires, and nanotubes.", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/adam12-antibody-ab28747.html", "date": "2020-09-26T21:25:32Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-40/segments/1600400245109.69/warc/CC-MAIN-20200926200523-20200926230523-00455.warc.gz", "language_score": 0.7722157835960388, "token_count": 856, "dump": "CC-MAIN-2020-40", "global_id": "webtext-fineweb__CC-MAIN-2020-40__0__171803990", "lang": "en", "text": "Key features and details\n- Goat polyclonal to ADAM12\n- Suitable for: WB\n- Reacts with: Human\n- Isotype: IgG\nProduct nameAnti-ADAM12 antibody\nSee all ADAM12 primary antibodies\nDescriptionGoat polyclonal to ADAM12\nSpecificityThis antibody is expected to recognise both the longer membrane bound form of human ADAM12 and the shorter soluble ADAM12 splice isoform. This antibody does not cross react with other ADAMS.\nTested applicationsSuitable for: WBmore details\nSpecies reactivityReacts with: Human\nStorage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.\nStorage bufferpH: 7.30\nPreservative: 0.02% Sodium azide\nConstituents: 0.5% Tris buffered saline, 0.5% BSA\nConcentration information loading...\nPurityImmunogen affinity purified\nPurification notesPurified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.\nOur Abpromise guarantee covers the use of ab28747 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\n|WB||Use a concentration of 0.1 - 0.3 µg/ml. Detects a band of approximately 95 kDa (predicted molecular weight: 100 kDa).\n1 hour primary incubation is recommended for this product.\nFunctionInvolved in skeletal muscle regeneration, specifically at the onset of cell fusion. Also involved in macrophage-derived giant cells (MGC) and osteoclast formation from mononuclear precursors.\nTissue specificityIsoform 1 is expressed in placenta and skeletal, cardiac, and smooth muscle. Isoform 2 seems to be expressed only in placenta or in embryo and fetus. Both forms were expressed in some tumor cells lines. Not detected in brain, lung, liver, kidney or pancreas.\nSequence similaritiesContains 1 disintegrin domain.\nContains 1 EGF-like domain.\nContains 1 peptidase M12B domain.\nDomainThe cysteine-rich domain supports cell adhesion through syndecans and triggers signaling events that lead to beta-1 integrin-dependent cell spreading. In carcinomas cells the binding of this domain to syndecans does not allow the integrin-mediated cell spreading.\nThe conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.\nmodificationsThe precursor is cleaved by a furin endopeptidase.\nCellular localizationSecreted and Cell membrane.\n- Information by UniProt\n- A disintegrin and metalloproteinase domain 12 antibody\n- ADA12_HUMAN antibody\n- ADAM 12 antibody\nAnti-ADAM12 antibody (ab28747) at 0.1 µg/ml + Human heart lysate (RIPA buffer, 30µg total protein per lane)\nPredicted band size: 100 kDa\nObserved band size: 95 kDa why is the actual band size different from the predicted?\nPrimary incubation was for 1 hour.\nDetected using chemiluminescence.\nab28747 has been referenced in 2 publications.\n- Liu J et al. MicroRNA-144 inhibits the metastasis of gastric cancer by targeting MET expression. J Exp Clin Cancer Res 34:35 (2015). WB . PubMed: 25927670\n- Estrella C et al. Role of A disintegrin and metalloprotease-12 in neutrophil recruitment induced by airway epithelium. Am J Respir Cell Mol Biol 41:449-58 (2009). IHC-P ; Human . PubMed: 19213876", "domain": "chemistry", "round": 3} +{"url": "https://www.hghanabolicsteroids.com/sale-10132726-raloxifene-hydrochloride-anti-estrogen-steroid-light-yellow-powder-cas-82640-04-8.html", "date": "2023-06-09T02:25:10Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-23/segments/1685224655244.74/warc/CC-MAIN-20230609000217-20230609030217-00655.warc.gz", "language_score": 0.8164883852005005, "token_count": 570, "dump": "CC-MAIN-2023-23", "global_id": "webtext-fineweb__CC-MAIN-2023-23__0__128516820", "lang": "en", "text": "Payment & Shipping Terms:\n|Product Name:||Raloxifene Hydrochloride||CAS:||82640-04-8|\n|Category:||Estrogen Steroid||Usage:||Bodybuilding Cycl PCT|\nnon estrogenic steroids,\nbodybuilding anabolic steroids\nRaloxifene Hydrochloride CAS 82640-04-8 anti estrogen steroid\n1. Raloxifene hcl, Raloxifene hydrochloride\n2. CAS No.: 82640-04-8\n3. MF: C28H28ClNO4S\n4. MW: 510.04\n5. Storage temp: -20°C Freezer\n6. Use: antineoplastic\n7. Appearance: light yellow powder\nRaloxifene Hydrochloride Discription:\n1. Raloxifene hydrochloride is an estrogen agonist/antagonist, referred to as a selective estrogen receptor modulator (SERM) and belongs to the benzothiophene class of compounds. The biological actions of raloxifene are largely mediated through binding to estrogen receptors.\n2. This binding results in activation of estrogenic pathways in some tissues (agonism) and and the blockade of estrogenic pathways in other tissues (antagonism). The agonistic or antagonistic activity of raloxiffene depends on the extent of recruitment of coactivators and corepressors to estrogen receptor (ER) target gene promotors.\n3. Raloxifene appears to act as an estrogen agonist in bone. It decreases bone resorption and bone turnover, increases bone mineral density and decreases fracture incidence.\nRaloxifene Hydrochloride Application:\n1. Raloxifene Hcl used to prevent & treat osteoporosis in women who have undergone menopause.\n2. Raloxifene Hcl used to decrease the risk of developing invasive breast cancer in women who are at high risk of developing this type of cancer or who have osteoporosis. Raloxifene Hcl cannot be used to treat invasive breast cancer or to prevent invasive breast cancer from coming back in women who have already had the condition.\n3. Raloxifene Hcl prevents and treats osteoporosis by mimicking the effects of estrogen to increase the density (thickness) of bone.\n4. Raloxifene Hcl decreases the risk of developing invasive breast cancer by blocking the effects of estrogen on breast tissue, which may stop the development of tumors that need estrogen to grow", "domain": "chemistry", "round": 3} +{"url": "http://onlinelibrary.wiley.com/doi/10.1111/j.1471-4159.2012.07882.x/abstract", "date": "2017-06-27T11:32:18Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-26/segments/1498128321309.25/warc/CC-MAIN-20170627101436-20170627121436-00308.warc.gz", "language_score": 0.8826128244400024, "token_count": 442, "dump": "CC-MAIN-2017-26", "global_id": "webtext-fineweb__CC-MAIN-2017-26__0__12077280", "lang": "en", "text": "Protein phosphatase-1M (PP1M, myosin phosphatase) consists of a PP1 catalytic subunit (PP1c) and the myosin phosphatase target subunit-1 (MYPT1). RhoA-activated kinase (ROK) regulates PP1M via inhibitory phosphorylation of MYPT1. Using multidisciplinary approaches, we have studied the roles of PP1M and ROK in neurotransmission. Electron microscopy demonstrated the presence of MYPT1 and ROK in both pre- and post-synaptic terminals. Tautomycetin (TMC), a PP1-specific inhibitor, decreased the depolarization-induced exocytosis from cortical synaptosomes. trans-4-[(1R)-1-aminoethyl]-N-4-pyridinylcyclohexanecarboxamide dihydrochloride, a ROK-specific inhibitor, had the opposite effect. Mass spectrometry analysis identified several MYPT1-bound synaptosomal proteins, of which interactions of synapsin-I, syntaxin-1, calcineurin-A subunit, and Ca2+/calmodulin-dependent kinase II with MYPT1 were confirmed. In intact synaptosomes, TMC increased, whereas Y27632 decreased the phosphorylation levels of MYPT1Thr696, myosin-II light chainSer19, synapsin-ISer9, and syntaxin-1Ser14, indicating that PP1M and ROK influence their phosphorylation status. Confocal microscopy indicated that MYPT1 and ROK are present in the rat ventral cochlear nucleus both pre- and post-synaptically. Analysis of the neurotransmission in an auditory glutamatergic giant synapse demonstrated that PP1M and ROK affect neurotransmission via both pre- and post-synaptic mechanisms. Our data suggest that both PP1M and ROK influence synaptic transmission, but further studies are needed to give a full account of their mechanism of action.", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/zch11-antibody-ab244409.html", "date": "2020-01-27T19:44:07Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-05/segments/1579251705142.94/warc/CC-MAIN-20200127174507-20200127204507-00231.warc.gz", "language_score": 0.7734371423721313, "token_count": 659, "dump": "CC-MAIN-2020-05", "global_id": "webtext-fineweb__CC-MAIN-2020-05__0__209613907", "lang": "en", "text": "Product nameAnti-ZCH11 antibody\nSee all ZCH11 primary antibodies\nDescriptionRabbit polyclonal to ZCH11\nTested applicationsSuitable for: ICC/IF, IHC-Pmore details\nSpecies reactivityReacts with: Human\n- ICC/IF: U-251 MG cells. IHC-P: Human smooth muscle tissue.\nStorage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.\nStorage bufferpH: 7.20\nPreservative: 0.02% Sodium azide\nConstituents: PBS, 40% Glycerol\nConcentration information loading...\nPurityImmunogen affinity purified\nOur Abpromise guarantee covers the use of ab244409 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\n|ICC/IF||Use a concentration of 1 - 4 µg/ml.\nFixation/Permeabilization: PFA/Triton X-100.\n|IHC-P||1/20 - 1/50. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.|\nFunctionUridylyltransferase that acts as a suppressor of microRNA (miRNA) biogenesis by specifically mediating the terminal uridylation of some miRNAs. Catalyzes the 3' uridylation of precursor let-7 (pre-let-7), a miRNA precursor. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Degradation of pre-let-7 contributes to the maintenance of embryonic stem (ES) cells and is required for ES cells to maintain pluripotency. Does not bind RNA by itself, recruited to pre-let-7 miRNAs via its interaction with LIN28A and LIN28B. Also catalyzes the 3' uridylation of miR-26A, a miRNA that represses IL6 transcript, leading to abrogate IL6 transcript repression and promote cytokine expression. May also suppress Toll-like receptor-induced NF-kappa-B activity via binding to T2BP. Does not play a role in replication-dependent histone mRNA degradation.\nSequence similaritiesBelongs to the DNA polymerase type-B-like family.\nContains 3 CCHC-type zinc fingers.\nContains 2 PAP-associated domains.\nmodificationsPhosphorylated upon DNA damage, probably by ATM or ATR.\nCellular localizationNucleus. Cytoplasm. Translocates into the cytoplasm following treatment of the cell with LPS.\n- Information by UniProt\n- DKFZp779C1943 antibody\n- EC 22.214.171.124 antibody\n- FLJ42878 antibody\nab244409 has not yet been referenced specifically in any publications.", "domain": "chemistry", "round": 3} +{"url": "https://blog.undercoatpaint.com/how-frequently-should-fuel-additives-be-used-in-commerical-vehicles/", "date": "2021-10-19T01:49:23Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-43/segments/1634323585231.62/warc/CC-MAIN-20211019012407-20211019042407-00204.warc.gz", "language_score": 0.9552501440048218, "token_count": 1072, "dump": "CC-MAIN-2021-43", "global_id": "webtext-fineweb__CC-MAIN-2021-43__0__75612632", "lang": "en", "text": "Fuel additives are fast becoming the go-to option for businesses who are looking to efficiently maintain their vehicles whilst maximising overall fuel efficiency. As the fuel additive market now exceeds 200,00 tonnes per year, and a total value tops £500 million, it’s no surprise that 95% of on-road retail fuel needs see additives as the driving force behind their businesses.\nAs we move further into the year 2021 there is still a lot of uncertainty around the effectiveness of these products. With the advantages that these additives bring to our vehicles being disguised by sceptics, many companies are left unsure if fuel additives are a worthwhile investment or they are another unnecessary expense.\nIn this article, we aim to discuss everything you need to know about fuel additives including how often they should be used and the key advantages they offer to commercial vehicles of all shapes and sizes.\nExplaining The Chemistry Behind Fuel Additives\nFuel additives prevent the wear and tear that develops from running a vehicle. Most additives contain cetane booster, lubricants, and detergents which not only help to reverse the carbon build-up but also help the vehicle to perform to its full potential. Applying these additives to your vehicle will react with carbon deposits which can release the build-up and transfer harmful solid deposits that may damage internal engine components.\nThe powerful detergents found within fuel additives will also help to stabilise your fuel. By, utilising new detergent technology injector cleaners help to provide a complete internal engine clean, down to molecular levels. Existing carbon and unburnt fuel deposits are rapidly removed giving the engine a complete clean which leaves the drive feeling good as new.\nKey Advantages To Using Fuel Additives In Vehicles\nAdditives have been carefully developed to help keep vehicles running to their maximum potential whilst providing budget-friendly fuel solutions with a premium feel. For those who are looking to run their vehicle day in and day out, additives should be an essential part pf your running costs.\nImproving Vehicle Fuel Efficiency\nMost fuel-burning engines are highly inefficient, especially those that are over 10 years old. Of all the fuel that is burnt, only around 12-30% is converted into power that moves the vehicle. This often leads to lots of energy being wasted at every step of the combustion process. Using a fuel injector can improve engine efficiency by 12 per cent because the fuel burns more efficiently. This will reduce the amount of waste generated and keep fuel costs down.\nRemoving Carbon Deposits\nEvery single time you start your car, fuel is being wasted, which is especially true with old vehicles. Often energy is lost due to heat and friction but there can also be the presence of incomplete combustion that can cause the build-up of carbon deposits within the engine. This build-up is known to dramatically impact the function of the vehicle and cause future problems. Fuel additives help to remove these build ups down to a molecular level. The frequent cleaning of your vehicle’s engine will help to improve the life expectancy of the vehicle and preventing breakdowns.\nImproving Cold Engine Start\nWhen we reach the colder months of the year our vehicles have to work harder to start-up in the morning. The oil and fuel within the engine will often thicken with this cold weather which creates friction that makes the initial engine start harder to achieve. By using fuel additives there is an increased lubricity which within the fuel allows your engine to receive the required power which helps to streamline the engine start.\nBoosting Commerical Vehicle Performance\nOften performance is a factor that is overlooked when considering the maintenance of commercial vehicles. With the nature of taxi and coach business being solely focused on fuel efficiency, performance is neglected and many take little notice to a vehicle that is ever decreasing in power. The use of fuel additives helps to turn cheap fuel into a much higher quality solution for the vehicle. This not only helps to give your car better engine performance but also helps maintain the engine and keep it running correctly.\nThe Frequency In Which Additives Should Be Use\nFuel additives are recommended to be used every 1,500 to 3,000 miles. With 22% of taxi drivers that are driving over 35,000 miles per year, fuel additives can be used a lot more frequently than you may expect. The frequency you maintain your vehicles with fuel additives are completely down to you, if the vehicle is within 5 years old it may be more cost-effective to slightly decrease frequency between application.\nFuel Additive Dose Rates\nMost fuel additives doses vary depending on the product which is being used. It is always recommended that you check the bottle before applying it to your vehicle. With fuel additives for diesel, the first dose rate is 1:1,000 and the maintenance dose rate is usually 1:1,500.\nDiesel fuel additives are a fundamental expensive for anyone who uses a vehicle for work on a day to day basis. By providing your engine with regular additives you can not only extend the life expectance of your vehicle but you can avoid breakdowns caused by carbon deposits. Make the investment today and watch how it will impact the long term health of the vehicle\nThe post How Frequently Should Fuel Additives Be Used In Commerical Vehicles appeared first on The Mechanic Doctor.", "domain": "chemistry", "round": 3} +{"url": "https://www.fortunachem.com/products/lonidamine-cas-50264-69-2/", "date": "2023-10-01T09:46:04Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233510810.46/warc/CC-MAIN-20231001073649-20231001103649-00666.warc.gz", "language_score": 0.7408937811851501, "token_count": 290, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__43802469", "lang": "en", "text": "Lonidamine is used to treat a variety of tumors, such as breast, prostate, lung and brain tumors.\nLonidamine mainly acts on the energy metabolism of cells, by changing the mitochondrial ultrastructure of tumor cells, inhibiting the activity of hexokinase bound to mitochondria, thereby reducing the glycolysis of tumor cells, and affecting the expression of apoptosis-related proteins, inhibiting the oxygen consumption of malignant cells to achieve the purpose of inhibiting tumor cells.\n|Package details:||100g,1kg/foil bag|\nHigh quality & competitive price\nFortunachem Provides Not Only Professional Chemical Products But Also Professional Help\nKeeping you up-to-date with all the latest information, news, and events about Fortunachem!", "domain": "chemistry", "round": 3} +{"url": "https://www.marknteladvisors.com/query/request-sample/middle-east-antiscalant-market.html", "date": "2023-06-02T22:54:08Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-23/segments/1685224648858.14/warc/CC-MAIN-20230602204755-20230602234755-00138.warc.gz", "language_score": 0.8629987835884094, "token_count": 464, "dump": "CC-MAIN-2023-23", "global_id": "webtext-fineweb__CC-MAIN-2023-23__0__50646488", "lang": "en", "text": "Antiscalants are added into feed water before it flows through the RO membrane. The infusion of antiscalants prevents scale formation by delaying the reaction time between magnesium and calcium, thereby allowing the water to be purified by RO systems seamlessly. In thermal desalination (MSF, MED) antiscalants are added to the feed water to prevent scale formation in boilers, cooling towers, and other equipment.\nThe Middle East Antiscalant Market is anticipated to grow at a CAGR of around 6% during the forecast period, i.e., 2021-26. The low availability of groundwater and increasing demand for desalination plants across the Middle East are the prime factors driving the antiscalant market. The constant degradation of the water quality index owing to the mounting transport & industrial pollution levels is astronomically fueling the need for reverse osmosis water treatment, which, in turn, is augmenting the demand for Antiscalants across the region.\n|Study Period||Historical Data: 2016-19|\n|Base Year: 2020|\n|Forecast Period: 2021-26|\n|Countries Covered||UAE, Saudi Arabia, Bahrain, Oman, Qatar, Kuwait, Others|\n|Key Companies Profiled||Nalco, Biolab, Veolia, Metito, Wetico, American Engineering Services (AES), Rawabi Chemicals, Fouz Chemical, DUBI Chem, Reza Industrial, Avista, BASF, BWA Water Additives, Kemira, General Electric (Lenntech), Solvay|\n|Unit Denominations||USD Million/Billion|\nFurther, the demand for antiscalants is also increasing across industries like Oil & Gas, Metal & Mining, Water Treatment, and Power Generation. This is because they help reduce the maintenance & operational costs and saves time. The Middle East accounts for a large share of the global oil reserve. Therefore, the increasing demand for antiscalants from the oil & gas industry is projected to drive the market in the coming years.\nImpact of Covid-19 on the Middle East Antiscalant Market", "domain": "chemistry", "round": 3} +{"url": "http://ubphj.nuph.edu.ua/article/view/ubphj.17.124", "date": "2022-05-23T04:57:57Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-21/segments/1652662555558.23/warc/CC-MAIN-20220523041156-20220523071156-00175.warc.gz", "language_score": 0.7623874545097351, "token_count": 2040, "dump": "CC-MAIN-2022-21", "global_id": "webtext-fineweb__CC-MAIN-2022-21__0__218709330", "lang": "en", "text": "Investigation of the cyproheptadine by chromatographic methods\nKeywords:cyproheptadine hydrochloride (peritol), identification, quantitation, HPLC (high performance liquid chromatography), TLC (thin layer chromatography)\nTopicality. Cyproheptadine hydrochloride (peritol) is an antihistaminic drug with an antiserotonin effect, which prevents development and facilitates the course of allergic reactions. The drug is characterized by antipruritic, antiexudative, anticholinergic and sedative effects. According to the literature sources, the drug can cause intoxication of the body and the lethal effects of overdosing, self-medication and in cases of suicide. The elaboration of highly sensitive and selective methods for the study of cyproheptadine, suitable for analysis in biological objects is an actual task.\nAim. To study the elaboration of algorithm for the directed analysis of cyproheptadine in biological extracts by HPLC and TLC methods.\nMaterials and methods. TLC studies were performed using 16 mobile solvent systems and three types of chromatographic plates. To identify the cyproheptadine were applied universally visualization conditions. HPLC studies were performed on a microcolumn liquid chromatograph “Milichrom A-02” (RPA “EkoNova” Novosibirsk, Russia) in a reversed-phase variant using a metal column with a non-polar sorbent Prontosil 120-5C 18 AQ.\nResults and discussion. TLC conditions for purifying cyproheptadine from biogenic impurities and its identification have been established. Based on the results of the studies, the behavior of cyproheptadine by the HPLC method was studied. Identification was carried out using retention parameters, spectral relationships, and quantitative determination using the absolute calibration method. The method is validated by parameters – range of linearity, limit of detection and quantitative determination, accuracy and precision.\nConclusions. It was established that the most suitable TLC conditions for CTA of cyproheptadine are: mobile solvent systems – ethyl acetate-methanol-25 % solution ammonium hydroxide (85 : 10 : 5), glass plates of firm “Merk” (Rfcyproheptadine = 0.50-0.55) and methanol, methanol-n-buthanol (60 : 40), Sorbphil-PTCX-AF-A (Rfcyproheptadine = 0.55-0.58). It is established that the HPLC-method may determine cyproheptadine in a concentration range of 10.0-200.0 µg/ml. The relative uncertainty of the average result is ± 2.05 %. An algorithm for the direct analysis of cyproheptadine in biological extracts by HPLC and TLC methods has been developed.\nMashkovskii, M. D. (2012). Lekarstvennye sredstva, 16 izd.Moscow: Novaia Volna, 1216.\nPrakash,S. Rathore, С. (2016). Cyproheptadine–dependent chronic serotonin syndrome. NeurologyIndia, 64 (6), 1319–1321. doi: 10.4103/0028–3886.193796\nMerhar, S. L., Pentiuk, S. P., Mukkada, V. A., Meinzen–Derr, J., Kaul, A., Butler, D. R. (2016). A retrospective review of cyproheptadine for feeding intolerance in children less than three years of age: effects and side effects. Acta Paediatrica, 105 (8), 967–970. doi: 10.1111/apa.13477\nKrasaelap, A., Madani, S. (2017). Cyproheptadine: A Potentially Effective Treatment for Functional Gastrointestinal Disorders in Children. Pediatrics Annals, 46 (3), 120–125. doi: 10.3928/19382359–20170213–01\nDabaghzadeh, F., Khalili, H., Ghaeli, P., Dashti–Khavidaki, S. (2012). Potential benefits of cyproheptadine in HIV–positive patients under treatment with antiretroviral drugs including efavirenz. Expert Opinion Pharmacotherapy, 13 (18), 2613–2624. doi: 10.1517/14656566.2012.742887\nLevine, B., Green–Johnson, D., Hogan, S., Smialek, J. E. (1998). A Cyproheptadine Fatality. Journal of Analytical Toxicology, 22 (1), 72–74. doi: 10.1093/jat/22.1.72\nHargrove, V., Molina, D. K. (2009). A Fatality Due to Cyproheptadine and Citalopram. Journal of Analytical Toxicology, 33 (8), 564–567. doi:10.1093/jat/33.8.564\nChu, F. K. (2011). Review of the epidemiology and characteristics of intentional cyproheptadine overdose in Hong Kong. Clinical Toxicology (Philadelphia), 49 (7), 681–683. doi: 10.3109/15563650.2011.602085\nKountourellis, J. E., Obete, K. O. (1995). Reversed–phase high performance liquid chronatographic determinaiton of cyproheptadine from urine by soli–phase extraction. Journal of Chromatography B: Biomedical Sciences and Applications, 664 (2), 468–471. doi: 10.1016/0378–4347(94)00476–l\nFeás, X., Ye, L., Hosseini, S. V., Fente, C. A., Cepeda, A. (2009). Development and validation of LC–MS/MS method for the determination of cyproheptadine in several pharmaceutical syrup formulations. Journal of Pharmaceutical and Biomedical Analysis, 50 (5), 1044–1049.doi: 10.1016/j.jpba.2009.06.006\nMaham, M., Kiarostami, V., Waqif–Husain, S., Abroomand–Azar, P., Tehrani, M.S., Khoeini Sharifabadi, M., Afrouzi, H., Shapouri, M., Karami–Osboo, R. (2013). Extraction and Determination of Cyproheptadine in Human Urine by DLLME–HPLC Method. Iranian Journal of Pharmaceutical. Research, 12 (2), 311–318.\nBasavaiah, K., Charan, V. S., Chandrashekar, U., Nagegowda, P., Somashekar, B. C. (2004). Isocratic high–performance liquid chromatographic determination of cyproheptadine hydrochloride in tablets. Bulgarian Chemical Communications, 36 (2), 112–116.\nCzerwińska, K., Wyszomirska, Е., Mazurek, A. P. (2013). Identification and determination of selected histamine antagonists by densitometric method. Acta Poloniae Pharmaceutica, 70 (1), 19–26.\nClarke, E. J. C. (2011). Isolation and Identification of Drugs in Pharmaceuticals, Body Fluids and Postmortem Material.London: The Pharm. Press, 2463.\nMamina, O. O., Rybalka, L. I., Lebedyn, A. M. (2015). Skryninh antyhistaminnykh preparativ u biolohichnykh obektakh metodom tonkosharovoi khromatohrafii. Kyiv, 11, 4.\nBolotov, V. V., Miroshnychenko, Yu. O., Klymenko, L. Yu., Akhmedov, E. Yu. (2012). Ukrainskyi medychnyi almanakh, 15 (5), 40–42.\nCopyright (c) 2017 National University of Pharmacy\nThis work is licensed under a Creative Commons Attribution 4.0 International License.Authors who publish with this journal agree to the following terms:\n- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.\n- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.\n- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).", "domain": "chemistry", "round": 3} +{"url": "https://www.shreejipharmainternational.com/nitroxynil-1187340.html", "date": "2022-09-26T18:47:18Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-40/segments/1664030334915.59/warc/CC-MAIN-20220926175816-20220926205816-00540.warc.gz", "language_score": 0.8606470823287964, "token_count": 487, "dump": "CC-MAIN-2022-40", "global_id": "webtext-fineweb__CC-MAIN-2022-40__0__201903022", "lang": "en", "text": "Nitroxynil has a nitro group along with a single iodine group. Nitroxynil is largely water insoluble. Usually, it is given subcutaneously to animals in the form of ethylglucamine salt, which is a water-soluble substance. Milk-producing animals cannot be administered this medication.\n- CAS Number: 1689-89-0\n- Name: Nitroxinil\n- Formula: C7H3IN2O3\n- Molecular Weight: 290.02\n- Synonyms: 2-Iodo-4-cyano-6-nitrophenol;3-Nitro-4-hydroxy-5-iodobenzonitrile;3-Nitro-5-iodo-4-hydroxybenzonitrile;4-Cyano-2-iodo-6-nitrophenol;4-Hydroxy-3-iodo-5-nitrobenzonitrile;M and B 10755;\n- EINECS: 216-884-8\n- Density: 2.24 g/cm3\n- Boiling Point: 280.1 °C at 760 mmHg\n- Flash Point: 123.2 °C\n- Appearance: White to yellow powder\n- Risk Codes:25-36/37/38-43\n- Safety: 26-36/37-45\n- Transport Information: UN 2811 6.1/PG 3\nHow to use:\nIn water, Nitroxynil is practically insoluble. Animals are usually injected subcutaneously with water-soluble ethylglucamine salts. Animals whose milk is consumed by humans shouldn't receive ethylglucamine injections.\nDosage of usage:\nNitroxinil is a narrow-spectrum anthelmintic primarily effective against blood-sucking roundworms, flukes and certain myiasis. Neither tapeworms nor most external parasites are affected by it. Injections containing it are moderately used in ruminants and usually mixed with other anthelmintics. Pigs, poultry, horses, and pets cannot be treated with it.\nThere are several symptoms to look for, such as excessive heart rate, hyperventilation, rapid breathing, and fever.", "domain": "chemistry", "round": 3} +{"url": "http://onlinelibrary.wiley.com/doi/10.1002/humu.22335/abstract", "date": "2016-10-01T10:27:53Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2016-40/segments/1474738662698.85/warc/CC-MAIN-20160924173742-00040-ip-10-143-35-109.ec2.internal.warc.gz", "language_score": 0.9074222445487976, "token_count": 288, "dump": "CC-MAIN-2016-40", "global_id": "webtext-fineweb__CC-MAIN-2016-40__0__140351476", "lang": "en", "text": "Cystathionine beta-synthase (CBS) deficiency is an inborn error of metabolism characterized by extremely elevated levels of plasma total homocysteine. The vast majority of CBS-deficient patients have missense mutations located in the CBS gene that result in the production of either misfolded or unstable protein. Here, we examine the effect of proteasome inhibitors on mutant CBS function using two different mouse models of CBS deficiency. These mice lack mouse CBS and express a missense mutant human CBS enzyme (either p.I278T or p.S466L) that has less than 5% of normal liver CBS activity, resulting in a 10–30-fold elevation in plasma homocysteine levels. We show that treatment of these mice with two different proteasome inhibitors can induce liver Hsp70, Hsp40, and Hsp27, increase levels of active CBS, and lower plasma homocysteine levels to within the normal range. However, response rates varied, with 100% (8/8) of the p.S466L animals showing correction, but only 38% (10/26) of the p.I278T animals. In total, our data show that treatment with proteostasis modulators can restore significant enzymatic activity to mutant misfolded CBS enzymes and suggests that they may be useful in treating certain types of genetic diseases caused by missense mutations.", "domain": "chemistry", "round": 3} +{"url": "https://www.nusagri.co.id/tag/feed-additive/", "date": "2024-03-02T06:29:52Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707947475757.50/warc/CC-MAIN-20240302052634-20240302082634-00687.warc.gz", "language_score": 0.9484235048294067, "token_count": 874, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__153357230", "lang": "en", "text": "Zeolites are minerals that contain hydrated aluminosilicate with alkali and alkaline-earth. Zeolites have so many benefits in many sectors, especially agriculture in general. There are many studies have found benefit of zeolite in agriculture. They are good for feed additive, soil conditioner, and even for maintaining good quality of water. In this article, we will discuss about how to mix zeolites for feed additive.\nAnyway, we have already discussed about the benefit of zeolites as feed additive. If you want to know more about benefit of zeolite, please check our article Benefit of Zeolite as Feed additive and More Quality Feed with Zeolite. There are lot of things that zeolites can do for animals.\nLet’s talk about animal husbandry. What kind of animal included in animal husbandry? Well, there are lot of animal, which can be consumed by human, not only for the meat, also for any resources that is needed for the industries. In example, animal husbandry include cow, sheep, pig, chicken, horse, goat, etc. To produce a thing, animals need feed. Feed that given by farmers must be qualified feed to get qualified product from animals. But, using qualified feed is not cost-friendly. If you have read our article about zeolite’s benefit, you have already known that zeolite able to make feed more efficient. With addition of zeolites, feed uses will decrease, and it will decrease the cost for animal feed.\nThe use of zeolite as feed is mainly related to animal nutrition. Zeolite’s properties able for retention of nitrogen and improving efficiency in protein digestion. Studies also shown zeolite relation with preservation of the environment due to capacity to retain pollutants of animal production, especially ammonia.\nHow to mix zeolites with animal feed?\nMany farmers accepted general composition of zeolite and feed. They are using 2 – 4 % of zeolite in feed. From those composition, we can make any mixed feed. For example, if we want to create 1000 kg of mixed feed, we can mix 960 kg of feed and 40 kg of zeolites. That will generate zeolite composition of 4 % zeolite in mixed feed. That composition can be applied to different animals in animal husbandry. But it is steel needed more studies about best composition for each animal.\nAccording to research, giving 1.5 % of zeolite will increase the egg production of chicken. In another research, using zeolites on laying hen manure in low ( 2,5 % ), medium ( 5 % ), and high ( 10 % ) doses, reduced NH3 emissions by 36 %, 62 %, and 92 % after seven days of storage. Zeolite also usually used in pig diets at concentrations from 0.5 % to 8 %. For cow, the zeolite composition for feed additive is 2 %. The study confirm that zeolite supplementation in dairy cows at moderate level was associated with the increase in dry matter intake, milk yield, 4% fat corrected milk, and components in milk.\nThe conclusion is zeolite have unique properties and fairly used in agriculture included animal husbandry. Zeolites have potential for pollution and waste control of the animal to reduce production of greenhouse gases. For feed additive, using zeolites mean improving the weight of animal, the production of eggs, and many more. But, specified portion of zeolite is needed to studied first before applying zeolite in feed. Therefore, this article is made to give example from studies that have done before about zeolite.\nThe present study confirms that zeolite supplementation in dairy cows at moderate level was associated with an increase in DMI, milk yield, 4% FCM, and components in milk. This increase was brought about by enhancing ruminal pH and acetate/ propionate ratio and by reducing ruminal ammonia level. We postulated that zeolite administration would alleviate the effects of a grain challenge and might affect the rumen or intestinal environment or modulate the acid-base metabolism. But at the high level, detrimental effects on milk production, milk quality, and ruminal environment are expected.", "domain": "chemistry", "round": 3} +{"url": "http://www1.katc.com/news/learn-if-your-drinking-water-is-safe/", "date": "2015-03-06T00:01:44Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2015-11/segments/1424936465069.3/warc/CC-MAIN-20150226074105-00275-ip-10-28-5-156.ec2.internal.warc.gz", "language_score": 0.9497801065444946, "token_count": 273, "dump": "CC-MAIN-2015-11", "global_id": "webtext-fineweb__CC-MAIN-2015-11__0__96905628", "lang": "en", "text": "Dec 12, 2013 6:01 PM by Tina Macias\nResidents in St. Martinville are concerned about some chemicals in their water that are known to cause health problems.\nOur investigative team learned that Bayou Teche Water Works violated the EPA's Safe Drinking Water Act this year because its water contains high levels of disinfectant byproducts, which can cause liver, kidney and nervous system problems along with increased risk of cancer after prolonged exposure. But it's unclear whether the contamination is directly connected to the St. Martinville residents' health issues.\nOur Akeam Ashford will have details at 5 p.m.\nOne other water system in St. Martin Parish, the City of St. Martinville's water system, was also cited for a similar issue by the state Department of Health and Hospitals this year.\nYou can learn about your individual water system through the DHH's Safe Drinking Water Program, which includes a database of samples taken at every water system. Search for your system here: http://new.dhh.louisiana.gov/index.cfm/page/1290\nEach water system is also required to complete an annual consumer confidence report. You can find your system's report here: http://new.dhh.louisiana.gov/index.cfm/page/1588", "domain": "chemistry", "round": 3} +{"url": "https://www.cstj.co.jp/products/55512.html", "date": "2019-03-24T20:11:24Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-13/segments/1552912203491.1/warc/CC-MAIN-20190324190033-20190324212033-00182.warc.gz", "language_score": 0.6741227507591248, "token_count": 717, "dump": "CC-MAIN-2019-13", "global_id": "webtext-fineweb__CC-MAIN-2019-13__0__51584249", "lang": "en", "text": "#55512 PLCγ2 (E5U4T) Rabbit mAb\n|PLCγ2 (E5U4T) Rabbit mAb recognizes endogenous levels of total PLCγ2 protein.|\n|Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human PLCγ2 protein.|\nホモロジー (相同性) 検索をご希望の場合 >>>\nWestern blot analysis of extracts from various cell lines using PLCγ2 (E5U4T) Rabbit mAb (upper) or β-Actin (D6A8) Rabbit mAb #8457 (lower).\nImmunoprecipitation of PLCγ2 from HCT 116 cell extracts. Lane 1 is 10% input, lane 2 is Rabbit (DA1E) mAb IgG XP® Isotype Control #3900, and lane 3 is PLCγ2 (E5U4T) Rabbit mAb. Western blot analysis was performed using PLCγ2 (E5U4T) Rabbit mAb.\nConfocal immunofluorescent analysis of HCT 116 cells (left, positive) and 22Rv1 cells (right, negative) using PLCγ2 (E5U4T) Rabbit mAb (green). Actin filaments were labeled with DyLight™ 554 Phalloidin #13054 (red). Samples were mounted in ProLong® Gold Antifade Reagent with DAPI #8961 (blue).\nPhosphoinositide-specific phospholipase C (PLC) plays a significant role in transmembrane signaling. In response to extracellular stimuli such as hormones, growth factors, and neurotransmitters, PLC hydrolyzes phosphatidylinositol 4,5-bisphosphate (PIP2) to generate two secondary messengers: inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG) (1). At least four families of PLCs have been identified: PLCβ, PLCγ, PLCδ, and PLCε. Phosphorylation is one of the key mechanisms that regulate the activity of PLC. PLCγ is activated by both receptor and non-receptor tyrosine kinases (2). PLCγ forms a complex with EGF and PDGF receptors, which leads to the phosphorylation of PLCγ at Tyr771, 783, and 1248 (3). Phosphorylation by Syk at Tyr783 activates the enzymatic activity of PLCγ1 (4). PLCγ2 is engaged in antigen-dependent signaling in B cells and collagen-dependent signaling in platelets. Phosphorylation by Btk or Lck at Tyr753, 759, 1197, and 1217 is correlated with PLCγ2 activity (5,6).\nTween is a registered trademark of ICI Americas, Inc.\nXP is a registered trademark of Cell Signaling Technology, Inc.\nProLong is a registered trademark of Life Technologies Corporation.\nCell Signaling Technology is a trademark of Cell Signaling Technology, Inc.\nDyLight is a trademark of Thermo Fisher Scientific, Inc. and its subsidiaries.", "domain": "chemistry", "round": 3} +{"url": "https://www.thermofisher.com/antibody/product/Phospho-ABL1-pTyr245-Antibody-Polyclonal/PA5-12532", "date": "2017-04-26T16:05:48Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-17/segments/1492917121453.27/warc/CC-MAIN-20170423031201-00037-ip-10-145-167-34.ec2.internal.warc.gz", "language_score": 0.806598961353302, "token_count": 424, "dump": "CC-MAIN-2017-17", "global_id": "webtext-fineweb__CC-MAIN-2017-17__0__57946897", "lang": "en", "text": "Immunofluorescent analysis of MCF-7 cells using a Phospho-ABL1 pTyr245 polyclonal antibody (Product # PA5-12532) at a dilution of 1:10-50, followed by a fluor-conjugated goat anti-rabbit secondary antibody (green). Nuclei were stained with DAPI (blue).\n|Tested species reactivity||Human, Mouse|\n|Host / Isotype||Rabbit / IgG|\n|Immunogen||KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y245 of human ABL1|\n|Purification||Antigen affinity chromatography|\n|Contains||0.09% sodium azide|\n|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|\n|Tested Applications||Dilution *|\n|Western Blot (WB)||1:1000|\n* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.\nABL1 is a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1.\nFor Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.", "domain": "chemistry", "round": 3} +{"url": "https://www.stratech.co.uk/products/28117-IBL/", "date": "2019-11-14T17:04:17Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-47/segments/1573496668529.43/warc/CC-MAIN-20191114154802-20191114182802-00507.warc.gz", "language_score": 0.8637683391571045, "token_count": 434, "dump": "CC-MAIN-2019-47", "global_id": "webtext-fineweb__CC-MAIN-2019-47__0__175382493", "lang": "en", "text": "Catalogue Number: 28117-IBL\n|Manufacturer:||IBL - (Immuno-Biologicals Laboratories Co Ltd)|\n|Physical state:||Lyophilized product from 1 % BSA in PBS containing 0.05 % NaN3|\n|Type:||Polyclonal Primary Antibody - Unconjugated|\n|Shipping Condition:||Blue Ice|\n|Unit(s):||100 ug, 10 ug|\n|Immunogen:||Synthetic peptide of the C terminal part of Human Tti1/KIAA0408 (ASGQQNPYTTNVLQLLKELQ)|\nDescription: Mammalian target of rapamycin (mTOR), a member of the phosphatidylinositol 3-kinase-related kinase (PIKK), is a major regulator of translation, cell growth, and autophagy. mTOR constitutes two distinct complexes, mTORC1 and mTORC2, that differ in their subunit composition.Tti1/KIAA0406 was identified as a novel mTOR-interacting protein. Tti1 constitutively interacts with mTOR in both mTORC1 and mTORC2. Knockdown of Tti1 suppresses phosphorylation of both mTORC1 substrates (S6K1 and 4E-BP1) and an mTORC2 substrate (Akt), and also induces autophagy. And it has been confirmed that Tti1 binds to Tel2 also in mammalian cells and Tti1 interacts with and stabilizes all six members of the PIKK family of proteins (mTOR, ATM, ATR, DNA-PKcs, SMG-1, and TRRAP). Furthermore, it has been reported that knockdown of either Tti1 or Tel2 causes disassembly of mTORC1 and mTORC2. These results indicate that Tti1 and Tel2 are important not only for mTOR stability but also for assembly of the mTOR complexes to maintain their activities.", "domain": "chemistry", "round": 3} +{"url": "https://pubmed.ncbi.nlm.nih.gov/1850420/?dopt=Abstract", "date": "2024-04-16T14:29:57Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712296817095.3/warc/CC-MAIN-20240416124708-20240416154708-00288.warc.gz", "language_score": 0.9487018585205078, "token_count": 321, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__204205419", "lang": "en", "text": "We report the DNA sequence and mutational analysis of a novel cluster of six Bradyrhizobium japonicum genes of which at least three (designated cycV, cycW, and cycX) are essential for the formation of all cellular c-type cytochromes. Mutants having insertions in these genes were completely devoid of any soluble (periplasmic) or membrane-bound c-type cytochromes; even the apo form of cytochrome c1 was not detectable, neither in the membrane nor in the soluble fraction. As a consequence, the mutants had pleiotropic phenotypes such as defects in nitrate respiration, H2 oxidation, electron transport to cytochrome alpha alpha 3, and microaerobic respiration during symbiosis. A fourth open reading frame (ORF132) encoded a protein that might also be concerned with cytochrome c formation, but perhaps only indirectly. The other two open reading frames did not appear to function in this process. The predicted amino acid sequences of the cycW and cycX gene products suggested that these proteins were membrane-bound. The cycV gene product showed extensive similarity to the ATP-binding subunit of a superfamily of membrane-associated transport systems. The predicted ORF132 product was strikingly similar to bacterial thioredoxins and eukaryotic protein disulfide isomerase. Based on these findings it is possible that these proteins are members of a complex transport system involved in the biogenesis of all cytochromes c.", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/gna11-antibody-ab153951.html", "date": "2020-10-20T00:25:06Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-45/segments/1603107867463.6/warc/CC-MAIN-20201019232613-20201020022613-00161.warc.gz", "language_score": 0.7284346222877502, "token_count": 528, "dump": "CC-MAIN-2020-45", "global_id": "webtext-fineweb__CC-MAIN-2020-45__0__11826440", "lang": "en", "text": "Key features and details\n- Rabbit polyclonal to GNA11\n- Suitable for: WB\n- Reacts with: Mouse, Human\n- Isotype: IgG\nProduct nameAnti-GNA11 antibody\nSee all GNA11 primary antibodies\nDescriptionRabbit polyclonal to GNA11\nTested applicationsSuitable for: WBmore details\nSpecies reactivityReacts with: Mouse, Human\nPredicted to work with: Rat, Chicken, Cow, Dog, Pig, Xenopus laevis, Zebrafish, Xenopus tropicalis\nRecombinant fragment, corresponding to a region within amino acids 173-359 of Human GNA11 (Uniprot ID P29992)\n- HeLa and NIH-3T3 whole cell lysates; A549, HepG2 and HCT116 cell lines.\nStorage instructionsShipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.\nStorage bufferpH: 7.00\nPreservative: 0.01% Thimerosal (merthiolate)\nConstituents: 1.21% Tris, 0.75% Glycine, 20% Glycerol\nConcentration information loading...\nPurityImmunogen affinity purified\nOur Abpromise guarantee covers the use of ab153951 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\n|WB||1/500 - 1/3000. Predicted molecular weight: 42 kDa.|\nFunctionGuanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C.\nSequence similaritiesBelongs to the G-alpha family. G(q) subfamily.\nCellular localizationCell membrane.\n- Information by UniProt\n- G alpha-11 antibody\n- G-protein subunit alpha-11 antibody\n- GA11 antibody\nab153951 has been referenced in 1 publication.\n- Govatati S et al. NFATc1-E2F1-LMCD1-Mediated IL-33 Expression by Thrombin Is Required for Injury-Induced Neointima Formation. Arterioscler Thromb Vasc Biol 39:1212-1226 (2019). PubMed: 31043075", "domain": "chemistry", "round": 3} +{"url": "https://scholars.duke.edu/display/pub776834", "date": "2021-10-24T01:13:21Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-43/segments/1634323585828.15/warc/CC-MAIN-20211023224247-20211024014247-00360.warc.gz", "language_score": 0.8908185958862305, "token_count": 582, "dump": "CC-MAIN-2021-43", "global_id": "webtext-fineweb__CC-MAIN-2021-43__0__228163421", "lang": "en", "text": "Increasing uptake and bioactivation with development positively modulate diazinon toxicity in early life stage medaka (Oryzias latipes).\nDiazinon, an organophosphate pesticide, becomes biotransformed to a more potent oxon metabolite that inhibits acetylcholinesterase (AChE). Early life stages (els) of medaka, Oryzias latipes, were used to determine how development of this teleost affects sensitivity to diazinon. With developmental progression, from day of fertilization to 7-day-old larvae, we found that the 96-h LC50 and AChE IC50 values decreased, indicating greater host sensitivity to diazinon upon continued development. We then examined changes in AChE activity, its inhibition by the active metabolite diazoxon, and uptake and bioactivation of the compound. AChE activity remained low during much of development but increased rapidly just prior to hatch. In addition, in vitro incubation of tissue homogenates from embryos or larvae showed no differences in the sensitivity of AChE to diazoxon. Uptake studies with 14C-diazinon revealed greater body burdens of 14C as medaka developed. In addition, AChE IC50 values determined by in vivo exposure to diazoxon were greater in larvae than in embryos. Because diazinon is bioactivated by the P450 enzyme system, two P450 inhibitors were used in vivo to explore the role of metabolism in sensitivity. When exposure to diazinon occurred in the presence of increasing amounts of piperonyl butoxide (PBO), AChE inhibition decreased in a dose-response fashion and 2.0 x 10(-5) M PBO alleviated any difference in inhibition between larvae and embryos. However, PBO did not alter total 14C uptake when exposed simultaneously with 14C-diazinon, nor did it affect AChE inhibition using diazoxon. Controls ruled out differential effects of PBO on uptake and inhibition. In addition, a second general P450 inhibitor, 1-aminobenzotriazole, also decreased AChE inhibition. Finally, using exogenous acetylcholinesterase as a trap for the oxon metabolite, larval microsomes displayed greater bioactivation of diazinon than did a microsomal preparation from embryos. Taken together, results suggest that uptake and bioactivation are working to enhance diazinon sensitivity in this developmental model of a teleost fish.\nHamm, JT; Wilson, BW; Hinton, DE\nVolume / Issue\nStart / End Page\nElectronic International Standard Serial Number (EISSN)\nInternational Standard Serial Number (ISSN)\nDigital Object Identifier (DOI)", "domain": "chemistry", "round": 3} +{"url": "http://www.lithiumprimarybattery.com/china-safety_performance_supercapacitor_battery_pack_7500mah_er14505_3_upc1550_type-8232462.html", "date": "2021-10-17T21:39:06Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-43/segments/1634323585183.47/warc/CC-MAIN-20211017210244-20211018000244-00058.warc.gz", "language_score": 0.8101834058761597, "token_count": 735, "dump": "CC-MAIN-2021-43", "global_id": "webtext-fineweb__CC-MAIN-2021-43__0__3102318", "lang": "en", "text": "Payment & Shipping Terms:\n|MaximumPulse Current:||200mA||Type:||ER14505-3 + UPC1550|\n|Rated Capacity:||7500mAh||Full-size:||Φ14.5×50.5mm + Φ15.1×50.5mm|\nsuper capacitor batteries,\nlithium battery pack\nSupercapacitor battery pack ER14505 - 3 + UPC1550 , with good safety performance\n|Battery discharged at continuous current 1.35mA until voltage reaches cut-off voltage 2.0V at ambient temperature 23±2℃|\n|Nominal Voltage||3.6 V|\n|Maximum Continuous Current||2.0A|\n|Battery with minimum 50% rated capacity discharged at ambient temperature 23±2℃|\n|Maximum Pulse Discharge Current||5.0A|\n|Battery with minimum 50% rated capacity discharged at max pulse for 3 seconds after 27seconds break. Ambient temperature 23±2℃|\nTemperature ≤ 30℃\nHumidity ≤ 75%RH\n|Operating Temperature||-55℃ to +85℃|\n|Battery Dimension||See drawing on pag|\n|Max self-discharged rate at ambient temperature 23±2℃|\n|Shelf Life||10 years|\n|Ambient temperature 23±2℃|\n1. Battery Characteristic\nAn auxiliary battery capacitor designed for large pulse current.\nCompared with the lithium SOCl2spiral battery, bobbin battery and UPC in parallel is more safety,and the combination can provide large discharge current compared with the single bobbin battery.\nSingle cell rated voltage 3.6V, the operating voltage varies with the load, normally between 3.3V and 3.6V\nThe specific energy density of each battery is 214Wh/kg\nWe provide a wide operating temperature range, from -55℃ to +85℃\nStable operating voltage, more than 90% of the capacity could be output with a fixed voltage\nUnder thecondition of normal temperature, the battery self -discharge rate of no more than 2% per year\nHermetic welding sealing to reduce the leakage for extending the shelf life to more than 10 years\n2. The working principle of UPC\nLithium SOCl2bobbin battery and UPC in parallel, high load of pulse completed by the Ultra Pulse Capacitor, not affected by the passivation.High load pulse bycompleted UPC, ahead of the next pulse lithium battery recharge UPC, after a full charge the discharge capacity ofUPC is constant, so on, until the battery capacity is completely consumed. In this way, we can guarantee the battery packa long life under the high load capacity.\n3. Product application areas\n4. FAQS of General Safety Instructions\nThe Battery should be stored in dry environment.\nKeep battery out of the children. If swallowed, please contact a physician at once.\nThe batteries can’t be short circuit. If positive and negative polarity of a battery is directly connected, this may cause a short circuit and this may lead to toxic materials or gas leakage and/or violent rupture.\nThe batteries of different electrochemical system, grades, or brands can’t be mixed because it would lead toxic material or gas leakage and/or a big rupture.\nBattery disposal method should be in accordance with local and state regulations.\nContact Person: Angela", "domain": "chemistry", "round": 3} +{"url": "https://iabcd.org.in/index.php/iabcd/article/view/33", "date": "2023-11-29T21:10:21Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100146.5/warc/CC-MAIN-20231129204528-20231129234528-00265.warc.gz", "language_score": 0.8819602131843567, "token_count": 481, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__266075296", "lang": "en", "text": "BIOCHEMICAL PROFILE OF EMBRYONIC AND NON-EMBRYONIC CALLUS OF CLERODENDRUM PHLOMIDIS L.\nClerodendrum phlomidis L. (Arani) is a medicinal plant used in the treatment of Diabetes mellitus. Enzymatic studies helps to differentiate between embryonic and non-embryonic callus at very early stage. In vitro experiments were conducted using leaf, stem, node, internode, apical bud as an explant. Callus cultured on MS basal medium supplemented with various combinations of 2, 4-D and Kinetin (1 : 1, 2 : 2, 3 : 3, 4 : 4, 5 : 5 mg/l 2,4-D : Kinetin). Large variations were observed in the callus cultures owing to hormonal variations. Higher hormonal concentration 5 mg/l 2, 4-D + 5 mg/l kinetin resulted in somatic embryoids while lower concentrations 1:1, 2:2, 3:3 mg/l, 2,4-D : kinetin resulted in non-embryonic cells. Enzymatic activities of peroxidase, IAA- oxidase, invertase, protease, and amylase, polyphenol oxidase (PPO), catalase and enzyme protein were estimated from cytoplasmic as well as wall-bound fractions of 2, 4, 6and 8 week old callus using standard methods. In two week old culture peroxidase and polyphenol oxidase (both wall bound and cytoplasmic) activity increases in non-embryonic callus and decreases in embryonic callus while IAA oxidase and Protease (both wall bound and cytoplasmic) activity decreases in non-embryonic callus and increases in embryonic callus. Total amylase and α-amylase activity of wall bound enzymes increases in non-embryonic callus and decreases in embryonic callus while cytoplasmic activity decreases in non-embryonic callus and increases in embryonic callus. On the basis of the above study enzymes could serve as a biochemical marker to determine the embryonic and non-embryonic callus at very early stage.", "domain": "chemistry", "round": 3} +{"url": "https://www.iit.it/people/martina-difrancesco", "date": "2020-12-04T02:45:55Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-50/segments/1606141733120.84/warc/CC-MAIN-20201204010410-20201204040410-00667.warc.gz", "language_score": 0.7546679377555847, "token_count": 1044, "dump": "CC-MAIN-2020-50", "global_id": "webtext-fineweb__CC-MAIN-2020-50__0__134648087", "lang": "en", "text": "Martina Di Francesco is a Post Doc in the Nanotechnology for Precision Medicine research line at Istituto Italiano di Tecnologia since May 2017. Her research activities focus on the design and the development of polymeric micro- and nano-constructs for delivering of different drugs (anti-inflammatory drugs and/or growth factors), in order to combine therapeutic activity and regenerative medicine.\nDr Di Francesco achieved her MSc Degree in Chemistry and Pharmacology Technology in October 2013 at the “G. d’Annunzio” University of Chieti – Pescara discussing the thesis “Implantable nanodevices for sustained zero-order release of liposomal nanodrugs”. In this work, she demonstrated that that nanochannels can be exploited to passively control the sustained release of intact liposomes from subcutaneously implantable reservoirs, designed for systemic delivery. Following that, she collaborated with a Pharmacy preparing and checking drugs following pharmacopoeia. In January 2014, she started her PhD in Life Sciences at the University of Catanzaro under the supervision of Prof. Massimo Fresta. Whilst completing her PhD thesis, she joined IIT for an internship leading her to her current position. Her PhD project “Supramolecular vesicular aggregates (SVAs) as innovative nanomedicine for the treatment of solid tumors” was the synthesis of and physical-chemical characterization of innovative supramolecular vesicular aggregates (SVAs) made up from different combinations of hydrophilic and hydrophobic surfactants or lipids for anticancer treatments.\nList of selected publications:\n- Di Francesco M, Grande R, Esposito S, Di Marzio L, “Niosomes as a delivery device for Vitamin A”, Advances in Food Safety and Health, 2014,6, 43-49;\n- Di Francesco M, Stancanelli R, Primavera R, Cannavà C, Tommasini S, Ventura CA, “Cyclodextrins in food science”, Advances in Food Safety and Health, 2014, 6, 4-21;\n- Primavera R, Di Francesco M, De Cola A, De Laurenzi V, Paolino D, Ciancaioni M, Carafa M, Celia C, Di Ilio C, Di Stefano A, Fresta M, Locatelli M, Di Marzio L, \"HPLC–FLD and spectrofluorometer apparatus: How to best detect fluorescent probe-loaded niosomes in biological samples, Colloids and Surfaces B: Biointerfaces, 2015, 135: 575–580; doi: 10.1016/j.colsurfb.2015.08.006;\n- De Rose RF, Maria Cristiano MC, Celano M, Maggisano V, Vero A, Lombardo GE, Di Francesco M, Paolino D, Russo D, Cosco D, \"PDE5 inhibitors-loaded nanovesicles: physico-chemical properties and in vitro antiproliferative activity\", Nanomaterials 2016, 6, 92; doi:10.3390/nano6050092;\n- Di Francesco M, Primavera R, Fiorito S, Cristiano MC, Taddeo VA, Epifano F, Di Marzio L, Genovese S, Celia C; “Acronychiabaueri Analogue Derivative-loadedUltradeformable Vesicles: Physicochemical Characterization and Potential Applications”, Planta Medica, 2016; doi:10.1055/s-0042-112225;\n- D'Angelo V, Tessari F, Bellagamba G, De Luca E, Cifelli R, Celia C, Primavera R, Di Francesco M, Paolino D, Di Marzio L, Locatelli M, “MicroExtraction by Packed Sorbent and HPLC-PDA quantification of multiple anti-inflammatory drugs and fluoroquinolones in human plasma and urine”, Journal of Enzyme Inhibition and Medicinal Chemistry, 2016; doi:10.1080/14756366.2016.120949;\n- Di Francesco M, Celia C, Primavera R, D'Avanzo N, Locatelli M, Fresta M, Cilurzo F, Ventura CA, Paolino D, Di Marzio L, Physicochemical Characterization of pH-responsive and Fusogenic Self-assembled Non-phospholipid Vesicles for a Potential Multiple Targeting Therapy, International Journal of Pharmaceutics, 2017, 528(1-2):18-32; doi: 10.1016/j.ijpharm.2017.05.055", "domain": "chemistry", "round": 3} +{"url": "http://www.abcam.com/N-WASP-antibody-ab32707.html", "date": "2013-05-22T23:45:38Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2013-20/segments/1368702525329/warc/CC-MAIN-20130516110845-00007-ip-10-60-113-184.ec2.internal.warc.gz", "language_score": 0.7370867133140564, "token_count": 682, "dump": "CC-MAIN-2013-20", "global_id": "webtext-fineweb__CC-MAIN-2013-20__0__205534113", "lang": "en", "text": "Anti-N WASP antibody (ab32707)\n- Product nameAnti-N WASP antibodySee all N WASP primary antibodies ...\n- DescriptionRabbit polyclonal to N WASP\n- Tested applicationsWB more details\n- Species reactivityReacts with: Human\nPredicted to work with: Cow, Orangutan\nSynthetic peptide conjugated to KLH derived from within residues 1 - 100 of Human N WASP.\n(Peptide available as ab32706.)\n- Positive controlThis antibody gave a positive signal in Human Testis Tissue Lysate.\n- Storage instructionsStore at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.\n- Storage bufferPreservative: 0.02% Sodium Azide\nConstituents: 1% BSA, PBS, pH 7.4\n- Concentration information loading...\n- PurityImmunogen affinity purified\n- Clonality Polyclonal\n- Research Areas\nOur Abpromise guarantee covers the use of ab32707 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\nNot yet tested in other applications.\nOptimal dilutions/concentrations should be determined by the end user.\n- FunctionRegulates actin polymerization by stimulating the actin-nucleating activity of the Arp2/3 complex. Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression.\n- Sequence similaritiesContains 1 CRIB domain.\nContains 1 WH1 domain.\nContains 2 WH2 domains.\n- Cellular localizationCytoplasm > cytoskeleton. Nucleus. Preferentially localized in the cytoplasm when phosphorylated and in the nucleus when unphosphorylated.\n- DKFZp779G0847 antibodyMGC48327 antibodyN-WASP antibody\n- Neural Wiskott Aldrich syndrome protein antibodyNeural Wiskott-Aldrich syndrome protein antibodyNWASP antibodyWASL antibodyWASL_HUMAN antibodyWiskott Aldrich syndrome gene like antibodyWiskott Aldrich syndrome gene like protein antibodyWiskott Aldrich syndrome like antibodyWiskottAldrich syndrome like antibody\nAnti-N WASP antibody images\nAnti-N WASP antibody (ab32707) at 1 µg/ml +\nTestis (Human) Tissue Lysate - adult normal tissue (ab30257) at 10 µg\nGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilution\ndeveloped using the ECL technique\nPerformed under reducing conditions.\nPredicted band size : 55 kDa\nObserved band size : 63 kDa (why is the actual band size different from the predicted?)\nExposure time : 12 minutes\nReferences for Anti-N WASP antibody (ab32707)\nab32707 has not yet been referenced specifically in any publications.", "domain": "chemistry", "round": 3} +{"url": "https://bv.fapesp.br/en/publicacao/121153/effect-of-the-environment-on-the-secondary-metabolic-profile/", "date": "2021-09-27T03:47:14Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-39/segments/1631780058263.20/warc/CC-MAIN-20210927030035-20210927060035-00154.warc.gz", "language_score": 0.9297695755958557, "token_count": 341, "dump": "CC-MAIN-2021-39", "global_id": "webtext-fineweb__CC-MAIN-2021-39__0__221517481", "lang": "en", "text": "Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, Lab Pharmacognosy, AsterBioChem Team, Av Cafe S-N, BR-14040903 Ribeirao Preto, SP - Brazil\nTotal Affiliations: 2\nJUL 7 2016.\nWeb of Science Citations:\nTithonia diversifolia is an invasive weed commonly found in tropical ecosystems. In this work, we investigate the influence of different abiotic environmental factors on the plant's metabolite profile by multivariate statistical analyses of spectral data deduced by UHPLC-DAD-ESI-HRMS and NMR methods. Different plant part samples of T. diversifolia which included leaves, stems, roots, and inflorescences were collected from two Brazilian states throughout a 24-month period, along with the corresponding monthly environmental data. A metabolomic approach employing concatenated LC-MS and NMR data was utilised for the first time to study the relationships between environment and plant metabolism. A seasonal pattern was observed for the occurrence of metabolites that included sugars, sesquiterpenes lactones and phenolics in the leaf and stem parts, which can be correlated to the amount of rainfall and changes in temperature. The distribution of the metabolites in the inflorescence and root parts were mainly affected by variation of some soil nutrients such as Ca, Mg, P, K and Cu. We highlight the environment-metabolism relationship for T. diversifolia and the combined analytical approach to obtain reliable data that contributed to a holistic understanding of the influence of abiotic environmental factors on the production of metabolites in various plant parts. (AU)", "domain": "chemistry", "round": 3} +{"url": "https://www.scienceopen.com/document?vid=59d91dca-fb6a-44e6-90c2-0dd417a98d6e", "date": "2021-06-21T20:49:16Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-25/segments/1623488289268.76/warc/CC-MAIN-20210621181810-20210621211810-00230.warc.gz", "language_score": 0.9374690651893616, "token_count": 322, "dump": "CC-MAIN-2021-25", "global_id": "webtext-fineweb__CC-MAIN-2021-25__0__48148317", "lang": "en", "text": "Objective: Acute corneal permeability change after instillation of benzalkonium chloride (BAC) was evaluated using a newly developed in vivo corneal transepithelial electric resistance (TER) measurement method. Method: Corneal TER was measured by Ag/AgCl electrodes placed in the anterior aqueous chamber and on the cornea of live rabbit eyes. TER was measured and TER change after instillation of 0.05% BAC solution was monitored. After TER measurement, cornea was excised and fixed for transmission and scanning electron microscopy. For the control study, physiologic saline was used instead of BAC. Results: The TER of normal rabbit cornea was 602.3 ± 195.0 Ωcm2. TER decreased instantly after instillation of 0.05% BAC. In 5 s, TER decreased to 58.3 ± 5.2%. In 60 s, TER decreased to 18.5 ± 3.2%. At all time points, TER after instillation of 0.05% BAC was significantly lower than that of the control (p < 0.0001). Dissociation of tight junctions and the destruction of superficial cell membranes were observed under electron microscopy. Conclusion: Corneal epithelial change with increased permeability is rapid and intense after the instillation of highly concentrated BAC solution, accompanied by disorder of tight junctions and cell membranes of superficial cells. The newly developed in vivo corneal TER measurement method is suitable for assessing acute corneal change after drug instillation.", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/recombinant-human-serinethreonine-protein-kinase-4--mst-1-ab159604.html", "date": "2018-09-20T03:14:19Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-39/segments/1537267156376.8/warc/CC-MAIN-20180920020606-20180920040606-00253.warc.gz", "language_score": 0.8301432728767395, "token_count": 589, "dump": "CC-MAIN-2018-39", "global_id": "webtext-fineweb__CC-MAIN-2018-39__0__153372513", "lang": "en", "text": "The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\nProtein concentration is above or equal to 0.05 mg/ml.\nPreviously labelled as Serine/threonine-protein kinase 4\nConcentration information loading...\nPreparation and Storage\nStability and Storage\nShipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.\npH: 8.00 Constituents: 0.31% Glutathione, 0.79% Tris HCl\nKinase responsive to stress\nMammalian STE20 like protein kinase 1\nMammalian STE20-like protein kinase 1\nMammalian sterile 20 like 1\nSerine/threonine kinase 4\nSerine/threonine protein kinase Krs 2\nSerine/threonine-protein kinase 4\nSerine/threonine-protein kinase Krs-2\nSTE20 like kinase MST1\nSTE20-like kinase MST1\nStress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. MST1/MST2 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation (By similarity). Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation.\nBelongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. Contains 1 protein kinase domain. Contains 1 SARAH domain.\nAutophosphorylated on serine and threonine residues.\nCytoplasm. Nucleus. The caspase-cleaved form cycles between the nucleus and cytoplasm.", "domain": "chemistry", "round": 3} +{"url": "https://www.antikoerper-online.de/abstract/Phosphoglycerate+Mutase+Family+Member+5+(PGAM5)+ELISA+Kit/", "date": "2018-02-24T00:25:44Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-09/segments/1518891814872.58/warc/CC-MAIN-20180223233832-20180224013832-00356.warc.gz", "language_score": 0.7023897171020508, "token_count": 1266, "dump": "CC-MAIN-2018-09", "global_id": "webtext-fineweb__CC-MAIN-2018-09__0__61904734", "lang": "en", "text": "Use your antibodies-online credentials, if available.\nKeine Produkte auf Ihrer Vergleichsliste.\nIhr Warenkorb ist leer.\nDisplays phosphatase activity for serine/threonine residues, and, dephosphorylates and activates MAP3K5 kinase. Zusätzlich bieten wir Ihnen PGAM5 Antikörper (8) und PGAM5 Proteine (7) und viele weitere Produktgruppen zu diesem Protein an.\nShowing 3 out of 4 products:\nthe mushroom body may possess an apoptosis-dependent toxic function, the suppression of which by dPGAM5 appears to be crucial for heat shock resistance.\nPGAM5 negatively regulates the PINK1 pathway related to maintenance of the mitochondria.\nPGAM5 regulates histidine phosphorylation to control TCR activation of CD4 (zeige CD4 ELISA Kits)-positive T cells.\nResults indicate that a multiprotein complex including PGAM5, Bax (zeige BAX ELISA Kits) and Drp1 (zeige CRMP1 ELISA Kits) proteins specifically formed during intrinsic apoptosis induction.\nResults identify a crucial role for RIPK3 (zeige RIPK3 ELISA Kits)-PGAM5-Drp1 (zeige CRMP1 ELISA Kits)/NFAT (zeige NFATC1 ELISA Kits) signalling in NKT (zeige SLC22A6 ELISA Kits) cell activation, and further suggest that RIPK3 (zeige RIPK3 ELISA Kits)-PGAM5 signalling may mediate crosstalk between mitochondrial function and immune signalling.\nThe BCL2L1 (zeige BCL2L1 ELISA Kits)-PGAM5-FUNDC1 (zeige FUNDC1 ELISA Kits) axis is critical for receptor-mediated mitophagy.\nDephosphorylation of FUNDC1 (zeige FUNDC1 ELISA Kits) by PGAM5 induces mitophagy.\nPGAM5 is proteolytically processed, accumulates in the cytosol during apoptosis, and sensitizes cells to death.\nRhomboid protease PARL (zeige PARL ELISA Kits) mediates the mitochondrial membrane potential loss-induced cleavage of PGAM5.\nExperimental data indicate that the two splice variants of the mitochondrial protein (zeige COX6B2 ELISA Kits) phosphatase PGAM5 are at the convergent point of multiple necrosis pathways.\nThe N terminus of the PGAM5 protein contains a conserved NXESGE motif that binds to the substrate binding pocket in the Kelch domain of Keap1 (zeige KEAP1 ELISA Kits).\nResults suggest that this member of the PGAM family has crossed over from small molecules to protein substrates and been adapted to serve as a specialized activator of ASK1 (zeige MAP3K5 ELISA Kits).\nResults revealed that RIPK1 (zeige RIPK1 ELISA Kits) and PGAM5 function independently to exert optimal control of Leishmania replication in the host.\nOur data demonstrate for the first time that PGAM5 plays an indispensable role in the pathogenesis of ConA-induced liver injury.\nwe also found that Pgam5-deficient mice are resistant to high-fat-diet-induced obesity. Our study uncovered that PGAM5 is involved in the whole-body metabolism in response to stresses that impose metabolic challenges on mitochondria.\nOur results revise the former proposal that PGAM5 acts downstream of RIP1 (zeige RALBP1 ELISA Kits)/RIP3 (zeige MPRIP ELISA Kits) to mediate necroptosis. Instead, PGAM5 protects cells from necroptosis by independently promoting mitophagy.\nPGAM5 is a novel regulator of inflammasome and caspase 1 (zeige CASP1 ELISA Kits) activity that functions independently of RIPK3 (zeige RIPK3 ELISA Kits).\nResults identify a crucial role for RIPK3 (zeige RIPK3 ELISA Kits)-PGAM5-Drp1 (zeige CRMP1 ELISA Kits)/NFAT (zeige NFATC1 ELISA Kits) signalling in NKT (zeige CTSL1 ELISA Kits) cell activation, and further suggest that RIPK3 (zeige RIPK3 ELISA Kits)-PGAM5 signalling may mediate crosstalk between mitochondrial function and immune signalling.\nLoss of PGAM5 disables PINK1-mediated mitophagy in vitro and leads to dopaminergic neurodegeneration and mild dopamine loss in vivo causing a Parkinson's-like movement disorder.\nData indicate that phosphoglycerate mutase 5 (PGAM5) contains an N-terminal WDXNWD motif required for multimerization and maximal phosphatase activity.\nPgam5 is essential for head formation, and for establishing and maintaining the Wnt (zeige WNT2 ELISA Kits)/beta-Catenin (zeige CTNNB1 ELISA Kits) signaling gradient that patterns the anterior-posterior body axis. We show that Pgam5 interacts with Dishevelled2 and that Dishevelled2 is a substrate of Pgam5.\nDisplays phosphatase activity for serine/threonine residues, and, dephosphorylates and activates MAP3K5 kinase. Has apparently no phosphoglycerate mutase activity. May be regulator of mitochondrial dynamics. Substrate for a KEAP1-dependent ubiquitin ligase complex. Contributes to the repression of NFE2L2- dependent gene expression (By similarity).\n, phosphoglycerate mutase 5\n, Bcl-XL-binding protein v68\n, serine/threonine-protein phosphatase PGAM5, mitochondrial", "domain": "chemistry", "round": 3} +{"url": "https://supermodelofrussia.ru/love/isobornyl-acrylate.php", "date": "2021-04-14T19:46:19Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-17/segments/1618038078021.18/warc/CC-MAIN-20210414185709-20210414215709-00116.warc.gz", "language_score": 0.9069217443466187, "token_count": 449, "dump": "CC-MAIN-2021-17", "global_id": "webtext-fineweb__CC-MAIN-2021-17__0__29637211", "lang": "en", "text": "Acrylic elastomers[ edit ] Acrylic elastomer is a general term for a type of synthetic rubber whose main component is acrylic acid alkyl ester ethyl or butyl ester. It is divided into old type and new type: Old types include ACM copolymer of acrylic acid ester and 2-chloroethyl vinyl ether containing chlorine and ANM copolymer of acrylic acid ester and acrylonitrile without chloride. Other than the slightly better water resistance of ANM, there are no physical differences; even processability is poor for both types. On the other hand, the new type of acrylic rubber does not contain any chlorine despite its unclear chemical composition.\n|Published (Last):||15 July 2013|\n|PDF File Size:||7.68 Mb|\n|ePub File Size:||7.98 Mb|\n|Price:||Free* [*Free Regsitration Required]|\nIt is an acrylic monomer used as an adhesive. Vidyard Video Among other applications, isobornyl acrylate is often used in medical devices. The selection was made based in part on multiple case reports of diabetes patients developing contact allergies to their diabetes devices, such as insulin pumps, explained Golara Honari, MD, of Stanford Calif.\nUniversity, who presented the selection at the ACDS annual meeting. The significance of this allergen is that testing through routine panels does not identify it, so clinician awareness is especially important, Dr.\nHonari noted in a video interview at the meeting. Most of the reported contact allergen cases have been in patients with diabetes, but clinicians should think about other possible sources, such as acrylic nails, she said.\nAs for treatment, clinicians and patients can consider alternative diabetes devices without isobornyl acrylate, she said. In the future, close collaboration between clinicians and the medical device industry to develop appropriate labeling can help increase awareness of the potential for allergic reactions, she added.\nHonari had no relevant financial conflicts to disclose. Next Article:.\nDermatologists name isobornyl acrylate contact allergen of the year\nRegister for a free account", "domain": "chemistry", "round": 3} +{"url": "https://www.clariant.com/en/Corporate/News/2014/02/Clariant-Container-Dri--II-Desiccants-Meet-New-FCC-Guidelines-for-Cocoa-Bean-Shipments", "date": "2024-02-25T05:38:58Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707947474581.68/warc/CC-MAIN-20240225035809-20240225065809-00479.warc.gz", "language_score": 0.9145270586013794, "token_count": 411, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__191514587", "lang": "en", "text": "Clariant Container Dri® II Desiccants Meet New FCC Guidelines for Cocoa Bean Shipments\n- Provide 65 percent or higher loading of calcium chloride, complying with Federation of Cocoa Commerce recommendations\n- Deliver highest moisture absorption performance of any calcium-chloride-based desiccant to optimize economics\n- Advanced formulation traps moisture as a thick gel, preventing spills\n\"The updated FCC guidelines make it clear that traditional silica gel desiccants are now considered less effective for moisture protection of cocoa beans vs. our Container Dri II desiccants,\" said Justin Mueller, head of Cargo & Device Protection, Clariant Corporation. \"Silica gel, while inexpensive, simply cannot absorb enough moisture to provide adequate protection for this valuable cargo. In contrast, our technology meets or surpasses the new recommendations with a smaller amount of desiccant, thanks to its exceptional absorption capabilities.\"\nCocoa beans are primarily grown in Africa, Indonesia and South America, and are typically transported by sea in large shipping containers to major markets in Europe, Asia and North America. To protect the delicate beans against damage from mold and mildew during long voyages, effective container desiccants are essential.\nThe Container Dri II line of specially designed cargo desiccants protect cargo during shipping by aggressively absorbing moisture from the air. This advanced Clariant technology reduces the dew point temperature (the temperature at which condensation begins to form, causing container rain as it is often called), keeping cargo safe and dry. Container Dri II absorbs up to three times its weight in moisture and traps it as a thick, no-spill gel. Container Dri II also has the ability to protect shipments from start to finish, through all temperature ranges and relative humidity variances, and continues to reduce the relative humidity down to levels below 40 percent RH, which decreases the dew point temperature even further.\nTo read the complete FCC guidelines for shipping cocoa, please visit the organization’s website at www.cocoafederation.com and become a member.", "domain": "chemistry", "round": 3} +{"url": "https://helensimmons012.livepositively.com/everything-you-need-to-know-about-smoke-bombs/", "date": "2023-03-29T23:56:53Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-14/segments/1679296949035.66/warc/CC-MAIN-20230329213541-20230330003541-00114.warc.gz", "language_score": 0.944084107875824, "token_count": 715, "dump": "CC-MAIN-2023-14", "global_id": "webtext-fineweb__CC-MAIN-2023-14__0__123873391", "lang": "en", "text": "A smoke bomb is a device that produces a thick, opaque smoke when ignited. They are often used for visual effects in films, stage productions, and outdoor events, as well as for signaling, training, and testing fire suppression systems.\nHowever, smoke bombs can also be misused, causing fires, injuries, and even death. It's important to understand the potential risks and legal implications of using smoke bombs, as well as how to handle them safely.\nTypes of smoke bombs:\nThere are several types of smoke bombs, including color smoke bombs, heat smoke bombs, and chemical smoke bombs.\nColor smoke bombs are used to produce a colored smoke effect. They typically contain a mixture of pyrotechnic chemicals, a dye, and a fuel, such as potassium chlorate, sulfur, and sugar. When ignited, the chemicals react to produce a smoke cloud of the desired color.\nHeat smoke bombs are used to create a smoke effect without producing a flame. They typically contain a heat-producing chemical, such as iron oxide, that reacts with a fuel to produce heat and smoke. Heat smoke bombs are often used in military and rescue training simulations, as they can create a realistic smoke environment without the risk of fire.\nChemical smoke bombs are used to produce a smoke effect for signaling or to test fire suppression systems. They typically contain a chemical, such as zinc chloride or potassium chloride, that reacts with water or moist air to produce a thick, white smoke.\nThe possession, use, and sale of smoke bombs is regulated by federal, state, and local laws. In the United States, it is illegal to possess or use a smoke bomb without a valid reason, such as for a theatrical production or military training. It is also illegal to sell smoke bombs to minors or to transport them across state lines without proper documentation.\nViolations of smoke bomb laws can result in fines, imprisonment, and seizure of the smoke bombs. It's important to be aware of the laws in your area and to obtain any necessary permits or licenses before using smoke bombs.\nSmoke bombs can be dangerous if not handled properly. They can cause fires, burns, and respiratory problems, as well as damage to property. It's important to follow these safety guidelines when using smoke bombs:\nOnly use smoke bombs in a well-ventilated area. The smoke produced by smoke bombs can be harmful if inhaled, and can cause respiratory problems and disorientation.\nWear protective gear. Smoke bombs can cause burns and other injuries. Wear protective clothing, such as gloves and goggles, to protect yourself from the heat and smoke.\nFollow the manufacturer's instructions. Smoke bombs can be unpredictable, and different types of smoke bombs have different ignition and handling procedures. Be sure to read and follow the manufacturer's instructions carefully.\nKeep smoke bombs away from flammable materials. Smoke bombs can ignite fires if they come into contact with flammable materials, such as paper, fabric, or dry grass. Keep smoke bombs away from these materials and make sure the area is clear before igniting them.\nDispose of smoke bombs safely. After a smoke bomb has been used, it may still be hot and potentially dangerous. Dispose of smoke bombs in a safe and responsible manner, following any specific disposal instructions provided by the manufacturer.\nBuying fireworks online following these guidelines, you can ensure the safe and legal use of smoke bombs. While smoke bombs can be a fun and effective tool for creating visual effects.", "domain": "chemistry", "round": 3} +{"url": "http://www.mdpi.com/2304-6732/3/2/31", "date": "2018-02-24T18:44:25Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-09/segments/1518891815918.89/warc/CC-MAIN-20180224172043-20180224192043-00066.warc.gz", "language_score": 0.7990978956222534, "token_count": 522, "dump": "CC-MAIN-2018-09", "global_id": "webtext-fineweb__CC-MAIN-2018-09__0__124449318", "lang": "en", "text": "Liver Status Assessment by Spectrally and Time Resolved IR Detection of Drug Induced Breath Gas Changes\nAbstractThe actual metabolic capacity of the liver is crucial for disease identification, liver therapy, and liver tumor resection. By combining induced drug metabolism and high sensitivity IR spectroscopy of exhaled air, we provide a method for quantitative liver assessment at bedside within 20 to 60 min. Fast administration of 13C-labelled methacetin induces a fast response of liver metabolism and is tracked in real-time by the increase of 13CO2 in exhaled air. The 13CO2 concentration increase in exhaled air allows the determination of the metabolic liver capacity (LiMAx-test). Fluctuations in CO2 concentration, pressure and temperature are minimized by special gas handling, and tracking of several spectrally resolved CO2 absorption bands with a quantum cascade laser. Absorption measurement of different 12CO2 and 13CO2 rotation-vibration transitions in the same time window allows for multiple referencing and reduction of systematic errors. This FLIP (Fast liver investigation package) setup is being successfully used to plan operations and determine the liver status of patients. View Full-Text\nScifeed alert for new publicationsNever miss any articles matching your research from any publisher\n- Get alerts for new papers matching your research\n- Find out the new papers from selected authors\n- Updated daily for 49'000+ journals and 6000+ publishers\n- Define your Scifeed now\nRubin, T.; von Haimberger, T.; Helmke, A.; Lock, J.; Stockmann, M.; Heyne, K. Liver Status Assessment by Spectrally and Time Resolved IR Detection of Drug Induced Breath Gas Changes. Photonics 2016, 3, 31.\nRubin T, von Haimberger T, Helmke A, Lock J, Stockmann M, Heyne K. Liver Status Assessment by Spectrally and Time Resolved IR Detection of Drug Induced Breath Gas Changes. Photonics. 2016; 3(2):31.Chicago/Turabian Style\nRubin, Tom; von Haimberger, Theodore; Helmke, Alexander; Lock, Johan; Stockmann, Martin; Heyne, Karsten. 2016. \"Liver Status Assessment by Spectrally and Time Resolved IR Detection of Drug Induced Breath Gas Changes.\" Photonics 3, no. 2: 31.\nNote that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.", "domain": "chemistry", "round": 3} +{"url": "https://rd.springer.com/chapter/10.1007/978-1-4757-2156-0_3", "date": "2018-09-20T14:27:10Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-39/segments/1537267156513.14/warc/CC-MAIN-20180920140359-20180920160759-00366.warc.gz", "language_score": 0.7245983481407166, "token_count": 421, "dump": "CC-MAIN-2018-39", "global_id": "webtext-fineweb__CC-MAIN-2018-39__0__37861105", "lang": "en", "text": "The characterization of materials is an important step to be taken before utilizing the materials for any purpose. Depending on the purpose, one can subject the material to mechanical, thermal, chemical, optical, electrical, and other characterizations to make sure that the material under consideration can function without failure for the life of the final product. We will consider only mechanical, thermal, and surface properties in this chapter while in the next chapter we will study electrical, optical, and diffusional properties.\nKeywordsContact Angle Loss Tangent Bone Cement Fracture Strength Viscoelastic Material\nUnable to display preview. Download preview PDF.\n- M. F. Ashby and D. R. H. Jones, Engineering Materials 1, Pergamon Press, Elmsford, N.Y., 1980.Google Scholar\n- W. D. Callister, Jr., Materials Science and Engineering: An Introduction (2nd Ed.), Chapters 6 and 9, J. Wiley and Sons, New York, 1991.Google Scholar\n- A. H. Cottrell, The Mechanical Properties of Matter, Chapters 4 and 8, J. Wiley and Sons, New York, 1964.Google Scholar\n- H. W. Hayden, W. G. Moffatt, and J. Wulff, The Structure and Properties of Materials, Vol. III, Chapters 1 and 2, J. Wiley and Sons, New York, 1965.Google Scholar\n- F. A. McClintock and A. S. Argon (eds.), Mechanical Behavior of Materials, Chapters 1 and 2, Addison-Wesley Publ. Co., Reading, Mass., 1966.Google Scholar\n- L. H. Van Vlack, Elements of Materials Science and Engineering (6th Ed.), Chapters 4 and 5, Addison-Wesley Publ. Co., Reading, Mass., 1970.Google Scholar\n- L. H. Van Vlack, A Textbook of Materials Technology, Chapters 2 and 9, Addison-Wesley Publ. Co., Reading, Mass., 1973.Google Scholar", "domain": "chemistry", "round": 3} +{"url": "https://www.creative-diagnostics.com/Anti-Rat-Endothelium-Antibody-54590-144.htm", "date": "2018-12-14T16:35:15Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-51/segments/1544376826145.69/warc/CC-MAIN-20181214162826-20181214184826-00258.warc.gz", "language_score": 0.7598763704299927, "token_count": 339, "dump": "CC-MAIN-2018-51", "global_id": "webtext-fineweb__CC-MAIN-2018-51__0__151583495", "lang": "en", "text": "Anti-Endothelium monoclonal antibody (DMABT-49806MR)\nMouse anti-Rat Endothelium monoclonal antibody for IHC, ELISA, FC, IP, RIA, WB\nBring this labeled antibody directly to your bench!\nAdd to basket\nRat peritoneal macrophages\nFCM: 1/50 - 1/100\n*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.\nEndothelium; Endothelial cells\nHave you cited DMABT-49806MR in a publication? Let us know\nand earn a reward for your research.\nZipperle, J; Schlimp, CJ; et al. A novel coagulation assay incorporating adherent endothelial cells in thromboelastometry. THROMBOSIS AND HAEMOSTASIS 109:869-877(2013).\nZhu, YQ; Ling, Y; et al. Magnetic resonance imaging of radiation-induced brain injury using targeted microparticles of iron oxide. ACTA RADIOLOGICA 53:812-819(2012).\nCustom Antibody Labeling\nWe offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody.", "domain": "chemistry", "round": 3} +{"url": "https://medical-dictionary.thefreedictionary.com/light+polymerization", "date": "2022-05-25T23:36:52Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-21/segments/1652662594414.79/warc/CC-MAIN-20220525213545-20220526003545-00544.warc.gz", "language_score": 0.8089957237243652, "token_count": 291, "dump": "CC-MAIN-2022-21", "global_id": "webtext-fineweb__CC-MAIN-2022-21__0__161289671", "lang": "en", "text": "Light polymerization | definition of light polymerization by Medical dictionary\nlight pol·y·mer·i·za·tion (līt poli-mĕr-ī-zāshŭn)\nUse of visible or ultraviolet illumination to excite a photoinitiator; which can initiate polymerization, usually of a resin.\nSynonym(s): light curing\nMedical Dictionary for the Dental Professions © Farlex 2012\nReferences in periodicals archive\nCaption: Figure 2: The light polymerization\nprocedure of the resin cement under zirconia of (a) 0[degrees] cusp inclination and (b) 20[degrees] or 30[degrees] cusp inclination.\nIVA shade was selected to minimize the effects of colorants on light polymerization\nInfluence of light polymerization\nmodes on degree of conversion and crosslink density of dental composites.\n(14,15) In previous studies, the use of a self-curing catalyst resulted in a higher degree of polymerization when compared with that achieved by light polymerization\nFor obtaining excellent properties of direct resins composites, a high- intensity light polymerization\nunit has been developed10.", "domain": "chemistry", "round": 3} +{"url": "https://pvc-wallpaper.cn/made-in-china-starch-adhesive-in-flakes/", "date": "2024-02-26T20:09:13Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707947474663.47/warc/CC-MAIN-20240226194006-20240226224006-00145.warc.gz", "language_score": 0.8194364309310913, "token_count": 680, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__138173595", "lang": "en", "text": "EPT-Welcoming Potato PowEPTWallpaper Glue Wallcovering Adhesive\nUncooked substance EPTed from German, included the PCMX technologies and recipe of US, removed the traditional resin creating specialized, in orEPTto get super strong viscosity and eco-environment , it specific the EPT fiber chain of rice. By way of the dehydration technological innovation, the liquid rice glue been altered into powEPTand enhance the glue viscosity, antibacterial mouldproof, and shelf lifestyle.so we have 2 years of shelf existence.\nModel NO.: C-three,C-four,C-4Plus\nMain Agent Composition: Organic Polymer\nPromoter Composition: EPTckifier\nHS Code: 35069900\nBonding Perform: Structural Adhesive\nApplication: Construction, Wallpaper Pasting\nClassification: Space Curing\nComposition: Natural and organic Materials\nTransportation Package: Carton EPT\ntwo.Drinking water-soluble, simple design\nfour.Environmental safety and non-toXiHu (West Lake) Dis.c\none. Initial of all, utilizing the wallpaper primer that it can shield the wall causing humidity successful.\n2. Utilizing a mount of drinking water in container, miXiHu (West Lake) Dis.ng sprinkle contents of sachet into h2o stirring rapidly right up until the powEPTis dispersed. Waiting for five-ten minutes then stir once more and entirely blend then employing.\n3. Brushing the glue paste evenly on the back of the wallpaper, fold the wallpaper into 50 % and hold out for 3 to 5 minutes right up until the glue paste penetrate the wallpaper and then use.\n4. Pasting :Set vertical basis well, paste the wallpaper from top to bottom in accordance with vertical basis, and then, by brush exterior into within, squeeze out the bubble and surplus glue.\n|C-4 in addition\n#9734Gluing: Brush the glue more than the back again of wallpaper evenly, then fold the wallpaper which is painted on the glue and place it for three to 5 minutes, pasting it after the glue infiltrate by means of the wallpaper.\n#9734Time of drying: In accordance to the kind of wallpaper, the temperature, humidity and ventilation situations of the space.\n#9734If there is abnormal phenomenon for the duration of construction, remember to stop the construction instantly and seek advice from retailer in orEPTto obtain professional assist.\nStorage amp Shelf Daily life\nStorage: 24 months.\nKeep in a amazing dry location absent from direct sunligEPT in an airtigEPT container.\nkeep out of children.\nAvoid contact with eyes, eliminate splashes from skin with soap and h2o.\nUse only when temperature is over 5 ordmC.\nHangZhou XiHu (West Lake) Dis.hu (West Lake) Dis. Chemical Co., Ltd. is one of the most significant adhesive makers in China, EPTizes in the study, manufacture and advertising and marketing of different types of adhesives, incEPTd: Polyurethane adhesive, spray adhesive, speak to adhesive, footwear adhesive, wallpaper glue, and so on. OEM is obtainable right here.", "domain": "chemistry", "round": 3} +{"url": "https://www.cellsignal.com/products/primary-antibodies/8582", "date": "2018-06-22T13:21:13Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-26/segments/1529267864482.90/warc/CC-MAIN-20180622123642-20180622143642-00281.warc.gz", "language_score": 0.8487362265586853, "token_count": 358, "dump": "CC-MAIN-2018-26", "global_id": "webtext-fineweb__CC-MAIN-2018-26__0__217930399", "lang": "en", "text": "Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.\nDab2 Antibody recognizes endogenous levels of total Dab2 protein.\nPolyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro222 of human Dab2 protein. Antibodies are purified by protein A and peptide affinity chromatography.\nDisabled homologue 2 (Dab2) is a mitogen responsive phosphoprotein that exerts multiple functions through association with numerous proteins. Dab2 modulates signaling pathways through interactions with proteins such as Smads and TGF-β receptors (1,2), axin (3), GRB (4) and Src (5). Dab2 also serves as a cargo-specific adaptor of clathrin-mediated endocytosis via interaction with clathrin (6), AP2 (7), NPXY-containing cargo (8-10), and myosin VI (11,12). In addition, Dab2 regulates cell adhesion by directly binding integrins (13,14). The diverse functions of Dab2 enable it to coordinate cell adhesion, cell motility, membrane trafficking, and signaling. Research studies have shown Dab2 is down-regulated in a number of cancers, thereby suggesting a role as a tumor suppressor (15-17). Phosphorylation of Dab2 decreases its endocytotic function (18).\nCell Signaling Technology is a trademark of Cell Signaling Technology, Inc.\nExplore pathways related to this product.", "domain": "chemistry", "round": 3} +{"url": "https://www.ornl.gov/news?f%5B0%5D=related_news_topics%3A1167&f%5B1%5D=related_news_topics%3A1174&f%5B2%5D=related_news_topics%3A1181&f%5B3%5D=related_news_topics%3A1202", "date": "2019-11-12T18:15:16Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-47/segments/1573496665726.39/warc/CC-MAIN-20191112175604-20191112203604-00297.warc.gz", "language_score": 0.9110792279243469, "token_count": 442, "dump": "CC-MAIN-2019-47", "global_id": "webtext-fineweb__CC-MAIN-2019-47__0__149772827", "lang": "en", "text": "Researchers at the Department of Energy’s Oak Ridge National Laboratory have received five 2019 R&D 100 Awards, increasing the lab’s total to 221 since the award’s inception in 1963.\nThree researchers at Oak Ridge National Laboratory will lead or participate in collaborative research projects aimed at harnessing the power of quantum mechanics to advance a range of technologies including computing, fiber optics and network communication.\nA team of researchers at Oak Ridge National Laboratory have demonstrated that designed synthetic polymers can serve as a high-performance binding material for next-generation lithium-ion batteries.\nScientists at Oak Ridge National Laboratory studying quantum communications have discovered a more practical way to share secret messages among three parties, which could ultimately lead to better cybersecurity for the electric grid and other energy assets.\nAn ORNL-led team's observation of certain crystalline ice phases challenges accepted theories about super-cooled water and non-crystalline ice. Their findings, reported in the journal Nature, will also lead to better understanding of ice and its various phases found on other planets, moons and elsewhere in space.\nOAK RIDGE, Tenn., March 11, 2019—An international collaboration including scientists at the Department of Energy’s Oak Ridge National Laboratory solved a 50-year-old puzzle that explains why beta decays of atomic nuclei\nVera Bocharova at the Department of Energy’s Oak Ridge National Laboratory investigates the structure and dynamics of soft materials—polymer nanocomposites, polymer electrolytes and biological macromolecules—to advance materials and technologies for energy, medicine and other applications.\nMore than 1800 years ago, Chinese astronomers puzzled over the sudden appearance of a bright “guest star” in the sky, unaware that they were witnessing the cosmic forge of a supernova, an event repeated countless times scattered across the universe.\nOAK RIDGE, Tenn., Feb. 12, 2019—A team of researchers from the Department of Energy’s Oak Ridge and Los Alamos National Laboratories has partnered with EPB, a Chattanooga utility and telecommunications company, to demonstrate the effectiveness of metro-scale quantum key distribution (QKD).", "domain": "chemistry", "round": 3} +{"url": "https://www.elsevier.com/books/neoglycoconjugates-part-b-biomedical-applications/lee/978-0-12-182148-7", "date": "2016-09-29T08:34:22Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2016-40/segments/1474738661780.47/warc/CC-MAIN-20160924173741-00265-ip-10-143-35-109.ec2.internal.warc.gz", "language_score": 0.6887969970703125, "token_count": 563, "dump": "CC-MAIN-2016-40", "global_id": "webtext-fineweb__CC-MAIN-2016-40__0__105231855", "lang": "en", "text": "Oligosaccharide Derivatives and Glycopeptides:\nH. Kunz and K. von dem Bruch, Neoglycoproteins from Synthetic Glycopeptides.\nK.G. Rice, Preparation of Fluorescent Glycoconjugates for Energy Transfer Studies.\nT. Tamura, M.S. Wadhwa, M.H. Chiu, M.L.C. Da Silva, T. McBoom, and K.G. Rice, Preparation of Tyrosinamide-Oligosaccharides as Iodinatable Glycoconjugates.\nT. Yoshida, Glycamine Formation via Reductive Amination of Oligosaccharides with Benzylamine.\nK. Koizumi, S. Kitahata, and H. Hashimoto, Preparation, Isolation, and Analysis of Heterogeneous Branched Cyclodextrins.\nT. Norborg, B. Laning, and J. Tejbrant, Solid-Phase Synthesis of O-Glycopeptides.\nY. Ichikawa, R. Wang, and C.-H. Wong, Regeneration of Sugar Nucleotide for Enzymatic Oligosaccharide Synthesis.\nS. Ogawa, Chemical Synthesis of Core Structures of Oligosaccharide Chains of Cell Surface Glycans Containing Carba Sugars.\nS. Ogawa and H. Tsunoda, Chemical Synthesis of Glycosylamide and Cerebroside Analogs Composed of Carba Sugars.\nJ.J. Krepinsky, D.M. Whitfield, S.P. Douglas, N. Lupescu, D. Pulleyblank, and F.L. Moolten, Galactosylation of Nucleosides at 5(- Position of Pentofuranoses.\nR. Brossmer and H.J. Gross, Sialic Acid Analogs and Application for Preparation of Neoglycoconjugates.\nR. Brossmer and H.J. Gross, Fluorescent and Photoactivatable Sialic Acids.\nS. Aoki, H. Kondo, and C.-H. Wong, Glycosyl Phosphites as Glycosylation Reagents.\nEnzymatic and Affinity Methods:\nM.M. Palcic, M. Pierce, and O. Hindsgaul, Synthetic Neoglycoconjugates in Glycosyltransferase Assay and Purification.\nA. Kobata, N. Kochibe, and T. Endo, Affin", "domain": "chemistry", "round": 3} +{"url": "https://alksignaling.com/final-results-in-figure-2a-are-western-blots-that-display-inhibit", "date": "2020-11-24T20:38:40Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-50/segments/1606141177566.10/warc/CC-MAIN-20201124195123-20201124225123-00256.warc.gz", "language_score": 0.953416645526886, "token_count": 890, "dump": "CC-MAIN-2020-50", "global_id": "webtext-fineweb__CC-MAIN-2020-50__0__204533736", "lang": "en", "text": "Benefits in Figure 2A are Western blots that present Inhibitors,Modulators,Libraries titration of BMS 345541 in two contaminated and one particular unin fected cells. Samples were handled for 48 hours and extracts have been manufactured for Western blotting. The top panel exhibits the caspase Western and also a gradual increase of p17 kind in MT 2 cells too as C8166 cells in concentrations among 0. 5 and 1. 0 M. There was no adjust in the actin levels in any in the samples treated. Panel B displays the outcomes of your Annexin V staining wherever dwell cells are repre sented in the bottom appropriate corner box in every single panel. All three samples had been handled with 0. one M of BMS 345541 and stained for that presence of dwell and apoptotic cells. Interestingly the two MT 2 and C8166 cells showed presence of handful of reside cells as compared to CEM cells when taken care of with BMS 345541.\nCollectively, these information indicate that reduced concentrations why of IKK inhibitor can apoptosis HTLV one cells way more efficiently as compared to uninfected cells. Result of BMS 345541 on inhibition of I B and p65 phosphorylation in vivo We subsequently asked if I B or p65 amounts could possibly be altered in drug handled contaminated and uninfected cells. We therefore Western blotted our drug handled cells with anti bodies towards I B, phospho I B, p65, phospho p65, p50, p52, Tax and actin. Both ser 32 of I B and ser 536 of p65 are phosphorylated by IKK in vivo. Success of such an experiment are proven in Figure 3 the place I B amounts fundamentally stayed the same in all 3 cell lines except for a drop in C8166 cells at five. 0 M.\nWe have previ ously observed that cells, irrespective of infection, treated with BMS 345541 at higher does are toxic and display non precise activation of apoptotic machinery. There was also no change in levels of p65 even though kinase inhibitor a slight boost in C8166 cells was observed at increased concentrations. A additional fascinating set of final results were observed with phosphor I B and phos phor p65 blots. MT 2 cells handled with BMS 345541 showed a reduction of each phosphor I B and phosphor p65 ranges at 0. 5 M. Very similar success have been also seen in C8166 cells. Incredibly very little phosphor I B and phosphor p65 were observed in CEM cells. P50, p52 ranges have been unchanged with many drug concentrations and Tax levels weren’t decreased at 0. 5 or one. 0 M concentration from the drug. No improvements had been observed in the actin amounts in any from the treated cells.\nCollectively, these success indicate that inhibition of IKK in HTLV 1 infected cells by BMS 345541 affects phosphorylation of both I B and p65 molecules, the two of which could be the hallmarks of NF B activation in HTLV 1 infected cells. Inhibition of cyclin CDK complexes by Purvalanol A We now have previously shown that cyclin E CDK2 kinase action is de regulated in HTLV 1 contaminated cells and these cells are especially susceptible to Purvalanol A treatment. Also, Purvalanol A, and that is a purine analog that competes with the ATP binding website in CDKs, is shown to inhibit cyclin E CDK2 and cyclin A CDK2 kinase routines with an IC50 of 0. 035 and 0. 07 M, respectively. We for that reason handled the two infected and uninfected cells for 48 hours with Purvalanol A and Western blotted for caspase three and PARP molecules. Benefits in Figure 4A present that the caspase three p17 molecule was current in contaminated cells treated with 0. 1 and 0. five M of Purvalanol A. This was vital due to the fact Purvalanol A did not considerably activate caspase 3 in CEM or Jurkat cells. There were no modifications in actin, cyclin E, or cyclin A expression levels when taken care of with Purvalanol A.", "domain": "chemistry", "round": 3} +{"url": "https://www.lsbio.com/antibodies/anti-per3-antibody-c-terminus-elisa-ihc-wb-western-ls-c17256/17997", "date": "2019-01-23T17:33:32Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-04/segments/1547584336901.97/warc/CC-MAIN-20190123172047-20190123194047-00349.warc.gz", "language_score": 0.6936801075935364, "token_count": 310, "dump": "CC-MAIN-2019-04", "global_id": "webtext-fineweb__CC-MAIN-2019-04__0__76770559", "lang": "en", "text": "PER3 antibody LS-C17256 is an unconjugated rabbit polyclonal antibody to human PER3. Validated for ELISA, IHC and WB.\n(tested or 100% immunogen sequence identity)\n- IHC - Frozen\n- Western blot (1 - 10 µg/ml)\n- ELISA (1:10000 - 1:100000)\nSee our complete line of Immunohistochemistry Reagents\nincluding antigen retrieval solutions, blocking agents\nABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.\nPER3 antibody was raised against synthetic peptide 20-aa sequence within C-terminus of human Per3 (KLH).\nRecognizes human Period Clock Protein 3. Species sequence homology: zebra fish 55%, Japanese quail and mouse 50%.\nSuitable for use in ELISA, Western Blot, Immunohistochemistry. Western Blot: 1-10 ug/ml using ECL. ELISA: 1:10000-1:100000 using 50-100 ng of control peptide/well. Immunohistochemistry: 2-20 ug/ml. Frozen, free floating sections.\n100 mM Tris, pH 7.5, 0.05% Sodium Azide, 40% Glycerol, 0.2% BSA\nShort term: 4°C. Long term: Store at -20°C. Avoid freeze-thaw cycles.\nFor research use only.", "domain": "chemistry", "round": 3} +{"url": "https://en.wikipedia.org/wiki/Trifluoromethylsulfonyl", "date": "2019-10-18T01:18:58Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-43/segments/1570986677412.35/warc/CC-MAIN-20191018005539-20191018033039-00541.warc.gz", "language_score": 0.7119284868240356, "token_count": 332, "dump": "CC-MAIN-2019-43", "global_id": "webtext-fineweb__CC-MAIN-2019-43__0__82556176", "lang": "en", "text": "Triflyl, more formally known as trifluoromethanesulfonyl, is a functional group with the formula F3CSO2–. The triflyl group is often represented by –Tf.\nThe related triflate group (trifluoromethanesulfonate) has the formula F3CSO2O–, and is represented by –OTf.\n- Triflyl azide, TfN3\n- Trioctylmethylammonium bis(trifluoromethylsulfonyl)imide, [MeN(C\n- Comins' reagent\n- Triflic anhydride (CF3SO2)2O is a very strong triflating agent.\n- Zeller, Wayne E.; Schwörer, Ralf (2009). \"N-Phenyltrifluoromethanesulfonimide\". e-EROS Encyclopedia of Reagents for Organic Synthesis. doi:10.1002/047084289X.rp142.pub2.\n- Baraznenok, Ivan L.; Nenajdenko, Valentine G.; Balenkova, Elizabeth S. (May 2000). \"Chemical Transformations Induced by Triflic Anhydride\". Tetrahedron. 56 (20): 3077–3119. doi:10.1016/S0040-4020(00)00093-4.\n|This organic chemistry article is a stub. You can help Wikipedia by expanding it.|", "domain": "chemistry", "round": 3} +{"url": "http://ningbobio.com/main-items/201353-bioss-primary-conjugated-antibodies-alexa-fluor/242239-kdm1a-antibody-alexa-fluor-594", "date": "2023-12-03T17:09:03Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100508.42/warc/CC-MAIN-20231203161435-20231203191435-00109.warc.gz", "language_score": 0.8737730979919434, "token_count": 712, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__137983608", "lang": "en", "text": "Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.\nThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human KDM1A\nStore this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.\nAOF2; KDM1; LSD1; BHC110; Lysine-specific histone demethylase 1A; BRAF35-HDAC complex protein BHC110; Flavin-containing amine oxidase domain-containing protein 2; KDM1A; KIAA0601\nFor facs or microscopy Alexa 1 conjugate.If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.\nBackground of the antigen\nHistone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity. Also acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and mediating demethylation of H3K9me, a specific tag for epigenetic transcriptional repression. The presence of PRKCB in ANDR-containing complexes, which mediates phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag that prevents demethylation H3K4me, prevents H3K4me demethylase activity of KDM1A. Demethylates di-methylated 'Lys-370' of p53/TP53 which prevents interaction of p53/TP53 with TP53BP1 and represses p53/TP53-mediated transcriptional activation. Demethylates and stabilizes the DNA methylase DNMT1. Required for gastrulation during embryogenesis. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Effector of SNAI1-mediated transcription repression of E-cadherin/CDH1, CDN7 and KRT8. Required for the maintenance of the silenced state of the SNAI1 target genes E-cadherin/CDH1 and CDN7.", "domain": "chemistry", "round": 3} +{"url": "https://wwww.politics-prose.com/book/9783030765538", "date": "2023-10-02T15:24:56Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233511000.99/warc/CC-MAIN-20231002132844-20231002162844-00721.warc.gz", "language_score": 0.9350212812423706, "token_count": 270, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__276696700", "lang": "en", "text": "Proceedings of the 3rd Rilem Spring Convention and Conference (Rscc 2020): Volume 2: New Materials and Structures for Ultra-Durability (Rilem Bookseries #33) (Paperback)\nThis book gathers peer-reviewed contributions presented at the 3rd RILEM Spring Convention and Conference, held at Guimar es and hosted by the University of Minho, Portugal, on March 9-14, 2020. The theme of the Conference was \"Ambitioning a Sustainable Future for Built Environment: comprehensive strategies for unprecedented challenges\", which was aimed at discussing current challenges and impacts of the built environment on sustainability. The present volume is dedicated to the topic \"New materials and structures for ultra‐durability\", which covers current scientific and technological developments aimed at improving knowledge about degradation mechanisms in construction materials, as well as to the development of new materials with extreme durability. Novel special materials for extreme environments or extreme loading conditions are also included, as well as novel approaches to improve the performance and durability of currently common construction materials. The following subtopics are included: general purpose, constructions, infrastructures and facilities; extreme environments and extreme events; transport and deterioration mechanisms, characterization and mitigation; Supplementary Cementitious Materials, admixtures, additions and other emerging material optimization strategies; smart materials for durable structures.", "domain": "chemistry", "round": 3} +{"url": "http://agentorangelegacy.blogspot.com/2014/03/roundup-weedkiller-linked-to-global.html", "date": "2021-11-28T21:36:30Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-49/segments/1637964358591.95/warc/CC-MAIN-20211128194436-20211128224436-00506.warc.gz", "language_score": 0.88710618019104, "token_count": 269, "dump": "CC-MAIN-2021-49", "global_id": "webtext-fineweb__CC-MAIN-2021-49__0__128908124", "lang": "en", "text": "READ ENTIRE OPEN ACCESS STUDY at this link>>>http://www.mdpi.com/1660-4601/11/2/2125\nThe extent of the health problem is so massive that the Center for Public Integrity found that CKDu has killed more people in El Salvador and Nicaragua than diabetes, AIDS and leukemia combined, over the past 5 years on record.\nTitled, \"Glyphosate, Hard Water and Nephrotoxic Metals: Are They the Culprits Behind the Epidemic of Chronic Kidney Disease of Unknown Etiology in Sri Lanka?\"” researchers hypothesized that while glyphosate is toxic, it alone is not capable of destroying kidney tissue on the scale recently observed in rice paddy regions of Northern Sri Lanka, or in El Salvador where it is the second leading cause of death among men. They propose glyphosate becomes extremely toxic to the kidney when it mixes with ‘hard’ water or heavy metals like arsenic and cadmium, either naturally present in the soil or added externally through fertilizer inputs. Hard water contains \"metals,\" such as calcium, magnesium, strontium and iron, along with carbonate, bicarbonate, sulphate and chlorides.\nContinue Learning: http://www.cornucopia.org/2014/03/11548", "domain": "chemistry", "round": 3} +{"url": "https://odessatxparks.org/303/Water-Treatment-Plant", "date": "2023-12-07T12:43:00Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100674.56/warc/CC-MAIN-20231207121942-20231207151942-00702.warc.gz", "language_score": 0.9536764621734619, "token_count": 440, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__130719215", "lang": "en", "text": "Water Treatment Plant\nThe Water Treatment Plant is located in Ector County Texas. All of the water processed at the plant is purchased untreated from the Colorado River Municipal Water District (CRMWD).\nSource of Untreated Water\nSurface or lake water is received year round. The majority of the surface water comes from Lake Ivie; however, water can be received from Lake Spence and Lake Thomas. During the warm weather months, groundwater is received from a well field in Ward County.\nThe surface water receives full treatment including:\n- pH Adjustment\nChemicals used in the coagulation process include alum (aluminum sulfate) and a polymer. Sodium hydroxide is used to adjust the pH of the water to ensure that it is stable, or non-corrosive. A chloramine disinfectant (combination of chlorine and ammonia) is used to ensure the bacteriological quality of the water through disinfection. The well water only requires pH adjustment with sodium hydroxide and disinfection with chloramines.\nStorage of Treated Water\nAfter treatment, water is stored on-site in covered clear wells until it is pumped into the distribution system. In addition to the water storage facilities at the Plant, there are three overhead water towers located in the water distribution system. These towers not only serve as storage facilities, but they also help enhance water pressures in the distribution system.\nThe Water Treatment Plant is designed to treat 50 million gallons per day (MGD), based on filter capacity. In addition, approximately 20 MGD of well water can be processed. The total amount of water treated annually is approximately 7 billion gallons.\nWater Quality Standards\nThe City of Odessa's water supply is approved by the Texas Commission on Environmental Quality (TCEQ). The water meets all of the Primary Drinking Water Standards established by the TCEQ and the Environmental Protection Agency to protect the public health.\nThe Water Treatment Plant is manned 24 hours per day by TCEQ licensed operators. In addition to the operational staff, maintenance personnel conduct preventive maintenance as well as the repairs required to ensure water can be processed and pumped into the distribution system on a continuous basis.", "domain": "chemistry", "round": 3} +{"url": "https://www.epigentek.com/catalog/ptprr-polyclonal-antibody-p-10648.html", "date": "2019-08-21T09:51:22Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-35/segments/1566027315865.44/warc/CC-MAIN-20190821085942-20190821111942-00072.warc.gz", "language_score": 0.7560921311378479, "token_count": 268, "dump": "CC-MAIN-2019-35", "global_id": "webtext-fineweb__CC-MAIN-2019-35__0__227168298", "lang": "en", "text": "Sequesters mitogen-activated protein kinases (MAPKs) such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactive form. The MAPKs bind to a dephosphorylated kinase interacting motif, phosphorylation of which by the protein kinase A complex releases the MAPKs for activation and translocation into the nucleus\nPTPRR Polyclonal Antibody. Unconjugated. Raised in: Rabbit.\nLiquid. 0.03% Proclin 300, 50% Glycerol, 0.01M PBS, PH 7.4.\n>95%, Protein G purified\nRecombinant Human Receptor-type tyrosine-protein phosphatase R protein (1-412AA)\nShipped at 4°C. Upon delivery aliquot and store at -20°C (short-term) or -80°C (long-term). Avoid repeated freeze.\nR-PTP-R, Ch-1PTPase, NC-PTPCOM1, Protein-tyrosine phosphatase PCPTP1, PTPRR ECPTP, PTPRQ\nELISA, IHC; Recommended dilution: IHC:1:20-1:200", "domain": "chemistry", "round": 3} +{"url": "https://bioblast.at/index.php/Martinez-Reyes_2020_Nature", "date": "2023-11-30T18:30:32Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100229.44/warc/CC-MAIN-20231130161920-20231130191920-00475.warc.gz", "language_score": 0.8469449877738953, "token_count": 597, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__191140453", "lang": "en", "text": "Martinez-Reyes 2020 Nature\n|Martínez-Reyes I, Cardona LR, Kong H, Vasan K, McElroy GS, Werner M, Kihshen H, Reczek CR, Weinberg SE, Gao P, Steinert EM, Piseaux R, Budinger GRS, Chandel NS (2020) Mitochondrial ubiquinol oxidation is necessary for tumour growth. Nature 585:288-92. https://doi.org/10.1038/s41586-020-2475-6|\nAbstract: The mitochondrial electron transport chain (ETC) is necessary for tumour growth1-6 and its inhibition has demonstrated anti-tumour efficacy in combination with targeted therapies7-9. Furthermore, human brain and lung tumours display robust glucose oxidation by mitochondria10,11. However, it is unclear why a functional ETC is necessary for tumour growth in vivo. ETC function is coupled to the generation of ATP-that is, oxidative phosphorylation and the production of metabolites by the tricarboxylic acid (TCA) cycle. Mitochondrial complexes I and II donate electrons to ubiquinone, resulting in the generation of ubiquinol and the regeneration of the NAD+ and FAD cofactors, and complex III oxidizes ubiquinol back to ubiquinone, which also serves as an electron acceptor for dihydroorotate dehydrogenase (DHODH)-an enzyme necessary for de novo pyrimidine synthesis. Here we show impaired tumour growth in cancer cells that lack mitochondrial complex III. This phenotype was rescued by ectopic expression of Ciona intestinalis alternative oxidase (AOX)12, which also oxidizes ubiquinol to ubiquinone. Loss of mitochondrial complex I, II or DHODH diminished the tumour growth of AOX-expressing cancer cells deficient in mitochondrial complex III, which highlights the necessity of ubiquinone as an electron acceptor for tumour growth. Cancer cells that lack mitochondrial complex III but can regenerate NAD+ by expression of the NADH oxidase from Lactobacillus brevis (LbNOX)13 targeted to the mitochondria or cytosol were still unable to grow tumours. This suggests that regeneration of NAD+ is not sufficient to drive tumour growth in vivo. Collectively, our findings indicate that tumour growth requires the ETC to oxidize ubiquinol, which is essential to drive the oxidative TCA cycle and DHODH activity.\n• Bioblast editor: Gnaiger E\nCorrection: FADH2 and Complex II\n- FADH2 is shown as the substrate feeding electrons into Complex II (CII). This is wrong and requires correction - for details see Gnaiger (2023).\nEnzyme: Complex II;succinate dehydrogenase", "domain": "chemistry", "round": 3} +{"url": "http://et.rcees.ac.cn/rcdw/yjry/fyjy/201907/t20190713_501913.html", "date": "2023-01-30T02:11:20Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-06/segments/1674764499790.41/warc/CC-MAIN-20230130003215-20230130033215-00485.warc.gz", "language_score": 0.6596765518188477, "token_count": 781, "dump": "CC-MAIN-2023-06", "global_id": "webtext-fineweb__CC-MAIN-2023-06__0__66487773", "lang": "en", "text": "1.Mao L, Liu YX, Huang CH, Gao HY, Kalyanaraman B, Zhu BZ*. Intrinsic Chemiluminescence Generation during Advanced Oxidation of Persistent Halogenated Aromatic Carcinogens. Environl Sci Technol, 2015, 49: 7940-7947.\n2.Zhu BZ*, Mao L, Huang CH, Qin H, Fan RM, Kalyanaraman B, Zhu JG. Unprecedented hydroxyl radical-dependent two-step chemiluminescence production by polyhalogenated quinoid carcinogens and H2O2. Proc Natl Acad Sci USA, 2012, 109: 16046-16051.\n3.Gao HY, Mao L, Li F, Xie LN, Huang CH, Shao, J, Shao B, Kalyanaraman, B, Zhu BZ*. Mechanism of Intrinsic Chemiluminescence Production from the Degradation of Persistent Chlorinated Phenols by the Fenton System: A Structure-Activity Relationship Study and the Critical Role of Quinoid and Semiquinone Radical Intermediates. Environl Sci Technol, 2017, 51: 2934-2943.\n4.Gao HY, Mao L, Shao B, Huang CH, Zhu BZ*. Why Does 2,3,5,6-Tetrachlorophenol Generate the Strongest Intrinsic Chemiluminescence among All Nineteen Chlorophenolic Persistent Organic Pollutants during Environmentally-friendly Advanced Oxidation Process? Sci Rep, 2016.10.17, 6: 33159.\n5.Zhu BZ*, Shen C, Gao HY, Zhu LY, Shao J, Mao L*. Intrinsic chemiluminescence production from the degradation of haloaromatic pollutants during environmentally-friendly advanced oxidation processes: Mechanism, structure-activity relationship and potential applications. J Environ Sci, 2017.12, 62: 68-83.\n6.Shao B, Mao L, Qu N, Wang YF, Gao HY, Li F, Qin L, Shao J, Huang CH, Xu D, Xie LN, Shen C, Zhou X, Zhu BZ*. Mechanism of Synergistic DNA Damage induced by the Hydroquinone Metabolite of Brominated Phenolic Environmental Pollutants and Cu(II): Formation of DNA-Cu Complex and Site-specific Production of Hydroxyl Radicals. Free Radic Biol Med., 2017, 104: 54-63.\n7.Zhu BZ, Mao L, Fan RM, Zhu JG, Zhang YN, Wang J Kalyanaraman B, Frei B. Ergothioneine Prevents Copper-Induced Oxidative Damage to DNA and Protein by Forming a Redox-Inactive Ergothioneine-Copper Complex. Chem Res Toxicol, 2011.1, 24: 30-34.\n8.Zhu BZ*, Zhu JG, Kalyanaraman B, Mao L, Shan GQ. Detoxifying polyhalogenated quinones by hydroxamic acids via an unusual double Lossen rearrangement. Proc Natl Acad Sci USA, 2010, 107: 20286-20290.\n9.Zhu BZ*, Shan GQ, Huang CH, Kalyanaraman B, Mao L, Du YG. Metal-independent decomposition of hydroperoxides by halogenated quinones: Detection and identification of a quinone ketoxy radical. Proc Natl Acad Sci USA, 2009, 106: 11466-11471.", "domain": "chemistry", "round": 3} +{"url": "https://www.pamper-parlour.com/product/global-eyes/", "date": "2023-12-01T15:48:42Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100290.24/warc/CC-MAIN-20231201151933-20231201181933-00319.warc.gz", "language_score": 0.8583177924156189, "token_count": 594, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__294659678", "lang": "en", "text": "This treatment specially adapted for the eye contour helps to reduce all signs of ageing.\nIt combines anti-ageing matrikines to fight against the effects of time, a silk tree to reduce puffiness and dark circles as well as an anti-wrinkles effect ingredient to help prevent sagging skin.\n89% Improvement of the fine lines and wrinkles appearance**\n86% Puffiness decongested*\n82% Dark circles blurred*\n*Results of self-evaluation on 22 women expressed in % of satisfaction after twice a day applications for 28 days.\n**% of respondents to instrumental measurements on 19 women after twice a day applications for 28 days.\nApplication advice : Apply onto the eye contour in the morning and/or evening.\nWHAT IT IS\nAlguoLift : This seawater compound enriched with an energising molecule comes from a micro algae subjected to arctic stress. By forming an invisible film, it tones the skin of the eye contour. It also helps to fight against the formation of lines and saggy puffiness, and also to firm up the eye contour.\nSilk tree extract : This extract comes from the tree Albizia julibrissin. Its leaves have the characteristic of opening to sunlight effect and closing at night. The extract has been specially developed to fight against the signs of fatigue caused by damaging glycation and glycoxidation. In this manner, it repairs the skin, reduces the production of toxins and helps to reduce the skin signs of fatigued such as puffiness and dark circles.\nAQUA (WATER), MACADAMIA INTEGRIFOLIA SEED OIL, GLYCERIN, GLYCERYL STEARATE, ALBIZIA JULIBRISSIN BARK EXTRACT, CETYL ALCOHOL, DIPROPYLENE GLYCOL, CAMELLIA SINENSIS LEAF WATER, DIMETHICONE, PEG-100 STEARATE, MICA, SORBITAN STEARATE, MARIS AQUA (SEA WATER), AVENA SATIVA (OAT) KERNEL EXTRACT, PALMITOYL PENTAPEPTIDE-4, SUCROSE, SODIUM DEXTRAN SULFATE, HYDROLYZED ALGIN, CAPRYLYL GLYCOL, ETHYLHEXYLGLYCERIN, DIMETHICONOL, POLYSORBATE 20, ALUMINUM HYDROXIDE, BUTYLENE GLYCOL, CARBOMER, 1,2-HEXANEDIOL, SODIUM SALICYLATE, CHLORPHENESIN, TRIETHANOLAMINE, PHENOXYETHANOL, SODIUM BENZOATE.", "domain": "chemistry", "round": 3} +{"url": "https://www.unboundmedicine.com/medline/citation/10614854/Screening_of_blood_donors_for_human_cytomegalovirus__HCMV__IgG_antibody_with_an_enzyme_immunoassay_using_recombinant_antigens_", "date": "2021-04-18T22:27:34Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-17/segments/1618038860318.63/warc/CC-MAIN-20210418194009-20210418224009-00242.warc.gz", "language_score": 0.8948934674263, "token_count": 491, "dump": "CC-MAIN-2021-17", "global_id": "webtext-fineweb__CC-MAIN-2021-17__0__148438509", "lang": "en", "text": "Screening of blood donors for human cytomegalovirus (HCMV) IgG antibody with an enzyme immunoassay using recombinant antigens.J Clin Virol. 1999 Dec; 14(3):173-81.JC\nScreening of blood donors for human cytomegalovirus (HCMV) infection is usually performed by the combined detection of specific IgG and IgM antibody. However, in most of the cases of primary infection HCMV IgG seroconversion is observed concomitantly to IgM production and HCMV IgM antibody detection for blood donor screening is subject to a relatively high frequency of false positive results.\nIn the present study a newly established HCMV IgG ELISA based on recombinant antigens (anti-HCMV recombinant IgG ELISA, Biotest) was evaluated in terms of sensitivity and specificity for blood donor screening.\nA total of 442 serum samples including follow-up sera of five patients suffering from primary HCMV infection, selected seropositive and seronegative blood donors and routine specimens were comparatively investigated with three HCMV antibody ELISAs (anti-HCMV recombinant IgG ELISA, Biotest; Enzygnost anti-CMV/IgG + IgM, Dade Behring; and Captia CMV-TA, Centocor).\nIgG seroconversion was detected with anti-HCMV recombinant IgG ELISA as early as IgM in all five patients suffering from primary infection. The alternative ELISAs were less sensitive, detecting seroconversion one to three bleeds later in 2 (Enzygnost anti-CMV/IgG + IgM) and 4 patients (Captia CMV-TA), respectively. Anti-HCMV recombinant IgG ELISA showed a 99.1% agreement with Enzygnost anti-CMV/IgG + IgM and/or Western blot in the preselected blood donors and routine specimens. Relatively high numbers of false negative (n=20) and positive results (n=7) were obtained with Captia CMV-TA.\nOur preliminary data suggest that HCMV antibody screening of blood donors can be performed reliably by detection of specific IgG provided that a highly sensitive assay system is used.", "domain": "chemistry", "round": 3} +{"url": "https://studysoup.com/tsg/341748/chemistry-12-edition-chapter-7-problem-7-94", "date": "2021-02-28T15:48:28Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-10/segments/1614178361510.12/warc/CC-MAIN-20210228145113-20210228175113-00278.warc.gz", "language_score": 0.8771801590919495, "token_count": 377, "dump": "CC-MAIN-2021-10", "global_id": "webtext-fineweb__CC-MAIN-2021-10__0__139513986", "lang": "en", "text": "A laser produces a beam of light with a wavelength of 532 nm. If the power output is 25.0 mW, how many photons does the laser emit per second? (1 W 5 1 J/s.)\nStep 1 of 3\nCH 111 Notes: Week 3 Polyatomic Ions: charged ions composed of two or more atoms, covalently bonded, that act as a single unit o Hydroxide OH - o Carbonate CO 2- 3 - o Bicarbonate HCO 3 o Nitrate NO 3- - o Nitrite NO 22- o Sulfate SO 4 o Sulfite SO 32- - o Acetate CH 33- 2 o Phosphate PO 4 o Ammonium NH 4+ - o Thiocyanate SCN- o Cyanide CN o Permanganate MnO 4\nAuthor: Raymond Chang; Kenneth Goldsby\nThe answer to “A laser produces a beam of light with a wavelength of 532 nm. If the power output is 25.0 mW, how many photons does the laser emit per second? (1 W 5 1 J/s.)” is broken down into a number of easy to follow steps, and 34 words. Since the solution to 7.94 from 7 chapter was answered, more than 302 students have viewed the full step-by-step answer. Chemistry was written by and is associated to the ISBN: 9780078021510. This textbook survival guide was created for the textbook: Chemistry, edition: 12. The full step-by-step solution to problem: 7.94 from chapter: 7 was answered by , our top Chemistry solution expert on 09/09/17, 04:35AM. This full solution covers the following key subjects: . This expansive textbook survival guide covers 25 chapters, and 3241 solutions.", "domain": "chemistry", "round": 3} +{"url": "https://insights.ovid.com/pgen/201407000/00130417-201407000-00004", "date": "2019-01-16T22:53:36Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-04/segments/1547583657907.79/warc/CC-MAIN-20190116215800-20190117001800-00269.warc.gz", "language_score": 0.8965703845024109, "token_count": 293, "dump": "CC-MAIN-2019-04", "global_id": "webtext-fineweb__CC-MAIN-2019-04__0__65364896", "lang": "en", "text": "Large interindividual variability in morphine pharmacokinetics could contribute to variability in morphine analgesia and adverse events.Methods:\nInfluence of weight, genetic polymorphisms, race and sex on morphine clearance and metabolite formation from 220 children undergoing outpatient adenotonsillectomy was studied. A nonlinear mixed effects model was developed in NONMEM to describe morphine and morphine glucuronide pharmacokinetics.Results:\nChildren with ABCC3 -211C>T polymorphism C/C genotype had significantly higher levels of morphine-6-glucuronide and morphine-3-glucuronide formation (˜40%) than C/T+T/T genotypes (p < 0.05). In this extended cohort similar to our earlier report, OCT1 homozygous genotypes (n = 13, OCT1*2–*5/*2–*5) had lower morphine clearance (14%; p = 0.06), and in addition complementing lower metabolite formation (˜39%) was observed. ABCB1 3435C>T TT genotype children had lower levels of morphine-3-glucuronide formation though no effect was observed on morphine and morphine-6-glucuronide pharmacokinetics.Conclusion:\nOur data suggest that besides bodyweight, OCT1 and ABCC3 genotypes play a significant role in the pharmacokinetics of intravenous morphine and its metabolites in children.", "domain": "chemistry", "round": 3} +{"url": "https://www.jci.org/articles/view/35206/figure/3", "date": "2017-09-23T18:18:27Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-39/segments/1505818689775.56/warc/CC-MAIN-20170923175524-20170923195524-00169.warc.gz", "language_score": 0.8844020366668701, "token_count": 585, "dump": "CC-MAIN-2017-39", "global_id": "webtext-fineweb__CC-MAIN-2017-39__0__240053594", "lang": "en", "text": "Overconsumption of lipid-rich diets, in conjunction with physical inactivity, disables and kills staggering numbers of people worldwide. Recent advances in our molecular understanding of cholesterol and triglyceride transport from the small intestine to the rest of the body provide a detailed picture of the fed/fasted and active/sedentary states. Key surprises include the unexpected nature of many pivotal molecular mediators, as well as their dysregulation — but possible reversibility — in obesity, diabetes, inactivity, and related conditions. These mechanistic insights provide new opportunities to correct dyslipoproteinemia, accelerated atherosclerosis, insulin resistance, and other deadly sequelae of overnutrition and underexertion.\nKevin Jon Williams\nIntegrated model of CM binding and hydrolysis on peripheral capillary endothelium.\nAdipose tissue and striated muscle each synthesize LpL, regulated by the fasted/fed and active/sedentary metabolic states. HSPGs on the surfaces of these cells capture and internalize LpL for degradation. LpL that escapes degradation will be picked up by HSPGs and VLDL receptors on the basal surface of overlying endothelial cells for transcytosis to the luminal surface of capillaries (orange arrows). Heparan sulfate side-chains of syndecan and glypican are denoted by chains of small spheres. The major HSPGs of endothelium, syndecans and glypicans, move into detergent-insoluble membrane microdomains (rafts) rich in caveolin-1 (CAV1) upon clustering. On the apical surface, they encounter GPIHBP1, which should also move into rafts upon clustering. The highly negatively charged N-terminal domain of GPIHBP1 binds LpL with approximately 10-fold greater affinity than do endothelial HSPGs. Thus, after transcytosis, LpL should be torn away from syndecans and glypicans onto GPIHBP1 (pink arrows). Dimers of GPIHBP1 bind LpL and CMs, thereby providing a platform for CM docking and triglyceride lipolysis. These processes are facilitated by apoC-II and apoA-V. Lipolysis generates NEFAs that are transported by another raft molecule, CD36, across the endothelium and into adipocytes for energy storage (blue arrows) or into striated myocytes for combustion (green arrows). After hydrolysis of CM triglycerides, the endothelium releases apoB48 remnant lipoproteins that are rich in LpL, apoE, and cholesteryl ester back into the circulation (red arrow). Under normal circumstances, these remnant particles undergo safe, swift uptake by the liver.", "domain": "chemistry", "round": 3} +{"url": "http://www.forskningsdatabasen.dk/catalog/2185811591", "date": "2017-09-21T09:08:46Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-39/segments/1505818687711.44/warc/CC-MAIN-20170921082205-20170921102205-00142.warc.gz", "language_score": 0.9506617784500122, "token_count": 297, "dump": "CC-MAIN-2017-39", "global_id": "webtext-fineweb__CC-MAIN-2017-39__0__154615081", "lang": "en", "text": "Human lung explants have been maintained in vitro for a period of 25 days. Autoradiographic studies indicated that the broncholar epithelial cells, type 2 alveolar epithelial cells, and stromal fibroblasts incorporated 3H-thymidine during the culture. After 7 to 10 days, type 2 cells were the predominant alveolar epithelial cell type. Lamellar inclusion bodies were released from the type 2 cells and accumulated in the alveolar spaces. The metabolism of benzo[alpha]pyrene (BP) in human lung explants cultured for up to 7 days was investigated. Human lung explants had measurable aryl hydrocarbon hydroxylase activity and could metabolize BP into forms that were bound to cellular DNA and protein. Peripheral lung had significantly lower aryl hydrocarbon hydroxylase activity than cultured bronchus but both tissues had similar binding levels of BP to DNA. Radioautographic studies indicated that all cell types in the peripheral lung can metabolize BP. The major ethylacetate extractable metabolites of BP formed by peripheral lung were tetrols and trans-7,8-diol. The primary water-soluble metabolite released with arylsulfatase and beta-glucuronidase was 3-hydroxybenzo[alpha]pyrene.\nLaboratory Investigation, 1978, Vol 38, Issue 6, p. 658-692", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/cxcl16-antibody-ab27222.html", "date": "2019-01-20T07:26:11Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-04/segments/1547583700734.43/warc/CC-MAIN-20190120062400-20190120084400-00033.warc.gz", "language_score": 0.7274062633514404, "token_count": 585, "dump": "CC-MAIN-2019-04", "global_id": "webtext-fineweb__CC-MAIN-2019-04__0__139549312", "lang": "en", "text": "Product nameAnti-CXCL16 antibody\nSee all CXCL16 primary antibodies\nDescriptionChicken polyclonal to CXCL16\nTested applicationsSuitable for: WBmore details\nUnsuitable for: IHC (PFA fixed)\nSpecies reactivityReacts with: Human\nRecombinant fragment, corresponding to amino acids 46-92 of Human CXCL16\n- E.coli derived fusion protein\nStorage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.\nStorage bufferConstituent: PBS\nConcentration information loading...\nPurityImmunogen affinity purified\nPurification notesab27222 is an affinity purified IgY.\nOur Abpromise guarantee covers the use of ab27222 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\nIs unsuitable for Immunohistochemistry (PFA fixed).\nNot yet tested in other applications.\nOptimal dilutions/concentrations should be determined by the end user.\nFunctionActs as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis (By similarity). Induces a strong chemotactic response. Induces calcium mobilization. Binds to CXCR6/Bonzo.\nTissue specificityExpressed in T-cell areas. Expressed in spleen, lymph nodes, lung, kidney, small intestine and thymus. Weak expression in heart and liver and no expression in brain and bone marrow.\nSequence similaritiesBelongs to the intercrine alpha (chemokine CxC) family.\nCellular localizationCell membrane. Secreted. Also exists as a soluble form.\n- Information by UniProt\n- C-X-C motif chemokine 16 antibody\n- Chemokine (C X C motif) ligand 16 antibody\n- Chemokine, CXC motif, ligand 16 antibody\nAnti-CXCL16 antibody (ab27222) at 1/2000 dilution + E coli derived fusion protein\ngoat anti IgY HRP at 1/1000 dilution\nDeveloped using the ECL technique.\nPredicted band size: 27 kDa\nObserved band size: 60 kDa why is the actual band size different from the predicted?\nExposure time: 1 hour\nNote: predicted size differs from the actual size as this represents a fusion protein.\nab27222 has not yet been referenced specifically in any publications.", "domain": "chemistry", "round": 3} +{"url": "https://www.sustainabilitymenews.com/environmental-social/sabic-gains-worlds-first-independent-certification-for-blue-hydrogen", "date": "2023-04-01T23:09:43Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-14/segments/1679296950363.89/warc/CC-MAIN-20230401221921-20230402011921-00744.warc.gz", "language_score": 0.9330185651779175, "token_count": 310, "dump": "CC-MAIN-2023-14", "global_id": "webtext-fineweb__CC-MAIN-2023-14__0__246928539", "lang": "en", "text": "SABIC Gains World’s First Independent Certification for Blue Hydrogen\nSABIC Agri-Nutrients Co., a Saudi Basic Industries Corp. subsidiary, has gained the world’s first independent certification for blue hydrogen and ammonia production.\nTÜV Rheinland, leading independent testing, inspection, and certification agency based in Germany, has certified the blue hydrogen and ammonia production facilities of SABIC AN and Saudi Arabian Oil Co.\nIt recognized SABIC’s Jubail facility for producing 37,800 tons of blue ammonia and Aramco’s wholly owned refinery in the same city, known as SASREF, for 8,075 tons of blue hydrogen.\nBEEAH Launches Recycling Facility with Robotics & AI\nCommenting on the certification, Bob Maughon, SABIC’s executive vice president of sustainability, technology and innovation, said: \"People will see more examples of that from us to come.”\nThe chemical giant is on a path to ensure that it reduces its carbon neutrality by 20 percent compared to its 2018 baseline.\nThe company is also on track to achieve net-zero for scope 1 and 2 emissions by 2050.\nSABIC currently emits approximately 53 million tons to 55 million tons of carbon per year. These figures are aligned with the Vision 2030 blueprint, which aims to reduce carbon emissions by 278 million tons per year by 2030.\nRead more: SIG Launches ‘Recycle for Good’ in Egypt", "domain": "chemistry", "round": 3} +{"url": "https://www.semanticscholar.org/author/V.-R.-Mamdapur/50351489", "date": "2020-02-26T04:15:45Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-10/segments/1581875146186.62/warc/CC-MAIN-20200226023658-20200226053658-00553.warc.gz", "language_score": 0.7756449580192566, "token_count": 266, "dump": "CC-MAIN-2020-10", "global_id": "webtext-fineweb__CC-MAIN-2020-10__0__119182226", "lang": "en", "text": "V. R. Mamdapur\nHighly Influential Citations1\nClaim Your Author Page\nAbstract A simple synthesis of (−)-muscone has been developed by using citronellal and oleyl alcohol as the starting materials.\nAbstract From the defensive secretions of water beetles Cybister limbatus , C. tripunctatus and C. confusus , a number of C-21 steroids viz. Δ 4 -pregnen-12β-ol-3,20-dione (I), Δ 4,6… Continue Reading\nSchi ldknech t et al. [t] have shown t he presence of s teroid h o r m o n e s as defensive subs t ances in t he secret ions of some wa te r beet le species. Our s tudies on t he secret ion of t he… Continue Reading\nTwo new syntheses of (Z)-jasmone (3; R = (Z)-CH2CH=CHCH2Me) are reported. One is based on an initial oxidative opening of a 2,5- disubstituted furan (1; R = (Z)-CH2CH2CH=CHCH2Me) to an enedione (2; R… Continue Reading", "domain": "chemistry", "round": 3} +{"url": "https://www.rcsb.org/structure/4n72", "date": "2020-09-18T14:19:50Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-40/segments/1600400187899.11/warc/CC-MAIN-20200918124116-20200918154116-00099.warc.gz", "language_score": 0.8724260926246643, "token_count": 726, "dump": "CC-MAIN-2020-40", "global_id": "webtext-fineweb__CC-MAIN-2020-40__0__103114223", "lang": "en", "text": "Structure and Function of the Catalytic Domain of the Dihydrolipoyl Acetyltransferase Component in Escherichia coli Pyruvate Dehydrogenase Complex.Wang, J., Nemeria, N.S., Chandrasekhar, K., Kumaran, S., Arjunan, P., Reynolds, S., Calero, G., Brukh, R., Kakalis, L., Furey, W., Jordan, F.\n(2014) J Biol Chem 289: 15215-15230\n- PubMed: 24742683\n- DOI: 10.1074/jbc.M113.544080\n- Primary Citation of Related Structures:\n- PubMed Abstract:\nThe Escherichia coli pyruvate dehydrogenase complex (PDHc) catalyzing conversion of pyruvate to acetyl-CoA comprises three components: E1p, E2p, and E3. The E2p is the five-domain core component, consisting of three tandem lipoyl domains (LDs), a per ...\nThe Escherichia coli pyruvate dehydrogenase complex (PDHc) catalyzing conversion of pyruvate to acetyl-CoA comprises three components: E1p, E2p, and E3. The E2p is the five-domain core component, consisting of three tandem lipoyl domains (LDs), a peripheral subunit binding domain (PSBD), and a catalytic domain (E2pCD). Herein are reported the following. 1) The x-ray structure of E2pCD revealed both intra- and intertrimer interactions, similar to those reported for other E2pCDs. 2) Reconstitution of recombinant LD and E2pCD with E1p and E3p into PDHc could maintain at least 6.4% activity (NADH production), confirming the functional competence of the E2pCD and active center coupling among E1p, LD, E2pCD, and E3 even in the absence of PSBD and of a covalent link between domains within E2p. 3) Direct acetyl transfer between LD and coenzyme A catalyzed by E2pCD was observed with a rate constant of 199 s(-1), comparable with the rate of NADH production in the PDHc reaction. Hence, neither reductive acetylation of E2p nor acetyl transfer within E2p is rate-limiting. 4) An unprecedented finding is that although no interaction could be detected between E1p and E2pCD by itself, a domain-induced interaction was identified on E1p active centers upon assembly with E2p and C-terminally truncated E2p proteins by hydrogen/deuterium exchange mass spectrometry. The inclusion of each additional domain of E2p strengthened the interaction with E1p, and the interaction was strongest with intact E2p. E2p domain-induced changes at the E1p active site were also manifested by the appearance of a circular dichroism band characteristic of the canonical 4'-aminopyrimidine tautomer of bound thiamin diphosphate (AP).\nFrom the Department of Chemistry, Rutgers University, Newark, New Jersey 07102, email@example.com.", "domain": "chemistry", "round": 3} +{"url": "https://digitalcommons.usu.edu/microscopy/vol1994/iss8/30/", "date": "2023-03-21T11:25:10Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-14/segments/1679296943695.23/warc/CC-MAIN-20230321095704-20230321125704-00728.warc.gz", "language_score": 0.8623213171958923, "token_count": 432, "dump": "CC-MAIN-2023-14", "global_id": "webtext-fineweb__CC-MAIN-2023-14__0__193553137", "lang": "en", "text": "Fluorescent probes allow measurement of dynamic changes of calcium and pH in living cells. Imaging using confocal scanning laser microscopy provides a route to spatially map these dynamics over time in single optical sections or in 3-D images. We have developed a dual-excitation confocal system to allow ratio measurements of pH and calcium, that compensate for changes in dye distribution, leakage and photobleaching. Application of these techniques to plant tissues is complicated by the difficulty in loading the tissues with dye. We describe a new technique to assist dye loading in intact leaves of Lemna using a pre-treatment with cutinase. Once within plant tissues, many dyes compartmentalise into the vacuole. We report the use of chloromethylfluorescein diacetate as an alternative to BCECF [2' ,7'-bis-(2-carboxyethyl)-5-(and 6)carboxyfluorescein] as a pH probe with greater cytoplasmic retention times. In addition, the confocal system allowed discrimination of signals from different compartments and permitted simultaneous measurement of vacuolar and cytoplasmic pH ratios in epidermal strips from Hordeum. We have developed a series of software tools to extract quantitative data from multi-dimensional images and illustrate these approaches with reference to pollen tube growth in Lilium and peptide-evoked changes in pH and calcium in stomata! guard cells from Commelina and Vicia.\nFricker, M. D.; Tlalka, M.; Ermantraut, J.; Obermeyer, G.; Dewey, M.; Gurr, S.; Patrick, J.; and White, N. S.\n\"Confocal Fluorescence Ratio Imaging of Ion Activities in Plant Cells,\"\nScanning Microscopy: Vol. 1994\n, Article 30.\nAvailable at: https://digitalcommons.usu.edu/microscopy/vol1994/iss8/30", "domain": "chemistry", "round": 3} +{"url": "https://www.rndsystems.com/products/human-pdx-1-ipf1-biotinylated-antibody_baf2419", "date": "2016-10-26T04:07:19Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2016-44/segments/1476988720615.90/warc/CC-MAIN-20161020183840-00474-ip-10-171-6-4.ec2.internal.warc.gz", "language_score": 0.8703161478042603, "token_count": 415, "dump": "CC-MAIN-2016-44", "global_id": "webtext-fineweb__CC-MAIN-2016-44__0__226195555", "lang": "en", "text": "PDX‑1/IPF1 in BG01V Human Embryonic Stem Cells. PDX‑1/IPF1 was detected in immersion fixed BG01V human embryonic stem cells differentiated to pancreatic progenitor cells using Goat Anti-Human PDX‑1/IPF1 Biotinylated Antigen Affinity-purified Polyclonal Antibody (Catalog # BAF2419) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Streptavidin (red; Catalog # NL999) and counterstained with DAPI (blue). Specific staining was localized to nuclei. View our protocol for Fluorescent ICC Staining of Cells on Coverslips.\nPreparation and Storage\nReconstitute at 0.2 mg/mL in sterile PBS.\nThe product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.\nStability & Storage\nUse a manual defrost freezer and avoid repeated freeze-thaw cycles.\n12 months from date of receipt, -20 to -70 °C as supplied.\n1 month, 2 to 8 °C under sterile conditions after reconstitution.\n6 months, -20 to -70 °C under sterile conditions after reconstitution.\nPDX-1, also known as islet/duodenum homeobox-1 (IDX-1), is a\nhomeodomain-containing transcription factor. During embryonic\ndevelopment, PDX-1 is required for pancreas differentiation in adult\nislet cells. PDX-1 regulates beta -cell specific gene expression and\nfunction. Human and mouse PDX-1 share 88% amino acid sequence homology.\nThe reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.", "domain": "chemistry", "round": 3} +{"url": "https://escholarship.org/uc/item/2h05v0cj", "date": "2022-10-03T19:20:55Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-40/segments/1664030337428.0/warc/CC-MAIN-20221003164901-20221003194901-00707.warc.gz", "language_score": 0.8698552846908569, "token_count": 282, "dump": "CC-MAIN-2022-40", "global_id": "webtext-fineweb__CC-MAIN-2022-40__0__183026014", "lang": "en", "text": "The mitochondrial carrier SFXN1 is critical for complex III integrity and cellular metabolism.\nPublished Web Locationhttps://doi.org/10.1016/j.celrep.2021.108869\nMitochondrial carriers (MCs) mediate the passage of small molecules across the inner mitochondrial membrane (IMM), enabling regulated crosstalk between compartmentalized reactions. Despite MCs representing the largest family of solute carriers in mammals, most have not been subjected to a comprehensive investigation, limiting our understanding of their metabolic contributions. Here, we functionally characterize SFXN1, a member of the non-canonical, sideroflexin family. We find that SFXN1, an integral IMM protein with an uneven number of transmembrane domains, is a TIM22 complex substrate. SFXN1 deficiency leads to mitochondrial respiratory chain impairments, most detrimental to complex III (CIII) biogenesis, activity, and assembly, compromising coenzyme Q levels. The CIII dysfunction is independent of one-carbon metabolism, the known primary role for SFXN1 as a mitochondrial serine transporter. Instead, SFXN1 supports CIII function by participating in heme and α-ketoglutarate metabolism. Our findings highlight the multiple ways that SFXN1-based amino acid transport impacts mitochondrial and cellular metabolic efficiency.", "domain": "chemistry", "round": 3} +{"url": "https://pubmed.ncbi.nlm.nih.gov/29409054/", "date": "2022-08-10T00:42:07Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571090.80/warc/CC-MAIN-20220809215803-20220810005803-00402.warc.gz", "language_score": 0.8971510529518127, "token_count": 389, "dump": "CC-MAIN-2022-33", "global_id": "webtext-fineweb__CC-MAIN-2022-33__0__38658123", "lang": "en", "text": "Context: Emerging evidence has related the gut microbiome and circulating metabolites to human obesity. Gut microbiota is responsible for several metabolic functions, and altered plasma metabolome might reflect differences in the gut microbiome.\nObjective: To identify a plasma metabolite profile associated with body mass index (BMI) in a general population and investigate whether such metabolite profile is associated with distinct composition of the gut microbiota.\nDesign: Targeted profiling of 48 plasma metabolites was performed in a population of 920 Swedish adults (mean age, 39 years; 53% women) from the ongoing Malmö Offspring Study using targeted liquid chromatography-mass spectrometry. Gut microbiota was analyzed by sequencing the 16S ribosomal RNA gene (V1-V3 region) in fecal samples of 674 study participants.\nResults: BMI was associated with 19 metabolites (P < 0.001 for all), of which glutamate provided the strongest direct association (P = 5.2e-53). By orthogonal partial least squares regression, a metabolite principal component predictive of BMI was constructed (PCBMI). In addition to glutamate, PCBMI was dominated by branched-chain amino acids (BCAAs) and related metabolites. Four gut microbiota genera (Blautia, Dorea, Ruminococcus, and SHA-98) were associated with both BMI and PCBMI (P < 8.0e-4 for all). When simultaneously regressing PCBMI and metabolite-associated gut bacteria against BMI, only PCBMI remained statistically significant.\nConclusions: We discovered associations between four gut microbiota genera (Blautia, Dorea, Ruminococcus, and SHA-98) and BMI-predictive plasma metabolites, including glutamate and BCAAs. Thus, these metabolites could be mediators between gut microbiota and obesity, pointing to potential future opportunities for targeting the gut microbiota in prevention of obesity.", "domain": "chemistry", "round": 3} +{"url": "https://eu.youthandearth.com/en-es/blogs/blog/sirtuins-nad-longevity", "date": "2024-04-16T16:14:50Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712296817103.42/warc/CC-MAIN-20240416155952-20240416185952-00283.warc.gz", "language_score": 0.94809490442276, "token_count": 2143, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__82166144", "lang": "en", "text": "In previous posts, we’ve discussed how important NAD+ is and how you can boost your levels of NAD+ by taking NMN. It is estimated that it is required for over 500 enzymatic processes in our bodies. NAD+ (nicotinamide adenine) is essential for life—it’s the natural fuel that powers all our body cells.\nSirtuins are special proteins that require NAD+ to regulate your cellular health. They regulate the pathways that control cellular death, they turn anti-aging genes on and off, repair DNA, and regulate our metabolism.\nIn this article, you will discover the connection between sirtuins, NAD+, and longevity and why it’s essential for your health.\nWhat’s The Connection Between Sirtuins and NAD+?\nNAD+ is found in every cell of our body and is essential for empowering and protecting our cells. When we have high levels of NAD+ in our bodies, cellular energy increases which becomes the fuel of life. As we age, however, our natural defenses and NAD+ levels decline, resulting in many age-related conditions and poor quality of life.\nSirtuins are a family of seven proteins that help regulate your cellular health. They play an important role in aging. However, sirtuins can only function in the presence of NAD+. In other words, if NAD+ levels are low, then sirtuins can’t do their job properly.\nDr. Leonard Guarente, the co-founder of Elysium Health, uses a general office set up as an analogy to describe how these two compounds come into play.\nHe relates our body cells to a company. In an organization, many people with different skills perform different tasks but with a common goal—to ensure the success of the business. The CEO of the company determines what needs to be done, why it needs to be done, and at what time. Even though he is the “boss,” he can’t operate on his own. He needs other team members, or at minimum finances, to keep the business operating.\nIt works the same for our bodies. In our cells, there are many compounds performing various tasks but all have the ultimate goal—stay healthy and function efficiently for as long as possible. Sirtuins play the role of CEO and determine what needs to be done and when. However, like the boss of a company, they can’t operate on their own: sirtuins need NAD+ to function.\nWhat is NAD+?\nDiscovered in 1906, NAD+ is a coenzyme found in all living cells. It’s responsible for maintaining healthy internal organs and a healthy neurological system.\nNot only does NAD+ convert nutrients into ATP, but it also works hand in hand with proteins like sirtuins to execute vital biological processes such as DNA repair and mitochondrial function.\nThe connection between sirtuins and NAD+ plays a significant role in controlling aging and longevity. This is because NAD+ provides a suitable working environment for the proteins, which in turn perform vital biological functions such as cell health regulation, turning anti-aging genes on and off, metabolism regulation, and DNA repair.\nHowever, research has shown that NAD+ availability declines with age unless you supplement with an NAD+ precursor such as NMN or NR. This, in turn, hinders the activity of sirtuins and therefore negatively affects all of the biological processes that it performs.\nNAD+ levels in your body decrease as you get older\nThere are many ways to naturally increase NAD+ levels in our bodies, these include:\nregular consumption of fish and vegetables\nHowever, the best way to boost your NAD+ levels is to take an NAD+ supplement.\nWhat are NAD+ Supplements?\nNAD+ supplements contain molecules known as NAD+ precursors. The most common NAD+ precursors are NR and NMN. These precursors can mimic calorie restriction, acute stress, and exercise and are effective at boosting NAD+ levels.\nThe human body can naturally create NAD+ by using these molecules. Although these precursors are readily available in foods such as fruits, meat, and vegetables, they exist in very low concentrations, and this is where supplementation with NMN, for instance, comes in.\nSupplements that contain polyphenols such as Resveratrol, Curcumin, and Quercetin can boost NAD+ to youthful levels, which then acts as fuel for the sirtuins gene.\nWhat are Sirtuins?\nSirtuins consist of seven proteins that are like members of a family or a group. Experts claim that our bodies are made up of at least 60,000 families of protein. The sirtuins family is one of them. Each member of the sirtuin family is located in different parts of the cell and has a different role to play, but all of them play a protective role in preventing damage to our DNA.\nWhen we mention proteins, you’re probably picturing dietary proteins such as chicken, meat, or legumes. However, in this case, we’re referring to protein as molecules. These molecules perform different roles in body cells.\nFor example, one of the general checks that your doctor may perform is to measure your “iron levels” or red blood cell count. What they are measuring is the levels of a protein molecule called hemoglobin which is responsible for transporting oxygen throughout your body. If your hemoglobin levels are low, you will be said to have a low red blood cell count or anemia.\nHow Do Sirtuins Make You Live Longer?\nSirtuins are known as one of the pathways to longevity because of the essential role that they play in our bodies. Some of these functions are:\nRegulates Epigenetic Modifications\nEpigenetics refers to external changes (modifications) to DNA that switch genes “off” and “on.” It’s the reason why cells in our skin look different to cells in our muscles. These cells contain the same DNA, but the genes are expressed differently.\nSirtuins are responsible for epigenetic modifications and building the connection between metabolism and epigenetics.\nResearch has shown that the manipulation of sirtuins could benefit lifespan due to epigenetic changes.\nMay help prevent Cancer\nWhen a cell becomes cancerous, cellular processes become abnormal. Sirtuins play an important role in regulating cellular processes such as cellular metabolism, maintaining chromatin structure, and maintaining genomic stability.\nAll of these processes become negatively affected when a cell is cancerous. Therefore, sirtuins can help minimize the risk of cancer, which, as we already know, is one of the leading causes of early death and poor quality of life.\nImproves Cardiovascular Function\nSirtuins can also boost cardiovascular function by inhibiting oxidative stress (cell damage caused by free radicals), regulating blood pressure, and ensuring homeostasis (a balanced cell environment) under stress and physiological conditions. Cardiovascular disease is one of the leading causes of early death. Therefore sirtuins can play an important role in preventing cardiovascular disease.\nBy increasing NAD+ levels, we can increase the functioning of sirtuins, which boosts our metabolism.\nAnother way through which sirtuins promotes longevity is by regulating metabolism.\nSirtuins regulate glucose and fat metabolism in response to physiological changes in energy levels. This helps maintain balanced energy levels and, as such, determines longevity.\nRegulates Neurological Function\nSirtuins play a crucial role in the regulation of brain function. Scientists have found that sirtuins can also boost memory and brainpower.\nAs we age and NAD+ level falls, the level of sirtuin activity declines which results in prolonged neuroinflammation, which leads to synaptic damage and neuronal death.\nAge-related decline in hypothalamic function (the part of the brain that controls body temperature, thirst, hunger, fatigue, sleep, circadian rhythms and some behavioral aspects such as attachment) can be caused by a reduction in SIRT1 activity.\nRegulates Inflammatory and Stress Response\nSirtuins defend and mend against inflammation and play essential but distinct roles in chronic and acute inflammation. Chronic inflammatory diseases often persist in a “low-sirtuins” state, and increasing SIRT1 levels or activity can be beneficial.\nSirtuins regulate many biological functions in the human body and is “longevity essential.” Without it, life as we know it cannot exist. There is a direct link between premature aging and reduced function of sirtuins.\nAs they say, “It takes two to tango.” As important as they are, sirtuins cannot function without NAD+, and we have already seen that NAD+ levels lower with age.\nHowever, due to technology and the advancement of human knowledge in science, we now have some power to control how we live and age. We no longer have to leave everything to fate, we can prevent premature aging and slow down the aging process, now that we know how NAD+, sirtuins, and longevity correlate.\nAlthough there are lifestyle adjustments you can make, one of the most effective ways to boost your levels of NAD+ is to supplement with high-quality NMN or our unique, all-natural supplement specifically designed to boost the longevity gene, Preservage. Our unique formula is designed to work deep within the body to slow down the aging process the natural way.\nIt’s time to be revitalized and slow down premature aging by partnering with those on the cutting edge of anti-aging products—Youth & Earth. Remember, it’s never too late as long as you start now!\nThe content of this article is for informational purposes only. It’s not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or health provider before starting a new health regime or program. Do not ignore medical advice or delay seeking it because of something you’ve read on this site or any Youth & Earth product.", "domain": "chemistry", "round": 3} +{"url": "https://www.manuelmenendez.com/2016/11/comparison-of-extracellular-and.html", "date": "2023-11-30T10:04:15Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100184.3/warc/CC-MAIN-20231130094531-20231130124531-00827.warc.gz", "language_score": 0.9305968284606934, "token_count": 347, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__145906515", "lang": "en", "text": "Many studies suggest oxidative stress as an early feature of Alzheimer's Disease (AD). However, evidence of established oxidative stress in AD peripheral cells is still inconclusive, possibly due to both, differences in the type of samples and the heterogeneity of oxidative markers used in different studies. Here we measured the activity of Superoxide Dismutase, Catalase and Glutathione Peroxidase both in the extracellular and the intracellular blood compartments of AD, MCI and control subjects. The amount of an open isoform of p53 protein (unfolded p53), resulting from oxidative modifications was also determined. Decreased SOD, increased GPx activity and higher p53 open isoform were found in both AD and MCI plasma compared to controls. In blood peripheral mononuclear cells, SOD activity was also decreased in both AD and MCI, and unfolded p53 increased exquisitely in younger AD males compared to controls. Overall, these data highlight the importance of considering both extracellular and intracellular compartments, in the determination of antioxidant enzyme activities as well as specific oxidation end-products, in order to identify peculiar systemic redox alterations in AD pathology.\nReference: Arce-Varas N, Abate G, Prandelli C, Martínez C, Cuetos F, Menéndez M, Marziano M, Cabrera-García D, Fernández-Sánchez MT, Novelli A, Memo M, Uberti D. Comparison of extracellular and intracellular blood compartments highlights redox alterations in Alzheimer's and Mild Cognitive Impairment patients. Curr AlzheimerRes. 2016", "domain": "chemistry", "round": 3} +{"url": "https://iubmb.qmul.ac.uk/enzyme/EC4/2/3/117.html", "date": "2021-12-02T11:58:32Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-49/segments/1637964362219.5/warc/CC-MAIN-20211202114856-20211202144856-00558.warc.gz", "language_score": 0.7249981164932251, "token_count": 701, "dump": "CC-MAIN-2021-49", "global_id": "webtext-fineweb__CC-MAIN-2021-49__0__176468466", "lang": "en", "text": "Reaction: geranyl diphosphate = ()-camphene + diphosphate\nFor diagram of reaction click here.\nGlossary: ()-camphene = (1S,4R)-2,2-dimethyl-3-methylenebicyclo[2.2.1]heptane\nOther name(s): CS\nSystematic name: geranyl-diphosphate diphosphate-lyase [cyclizing, ()-camphene-forming]\nComments: ()-Camphene is the major product in Abies grandis (grand fir) with traces of other monoterpenoids . In Pseudotsuga menziesii (Douglas-fir) there are about equal parts of ()-camphene and ()-α-pinene with traces of four other monoterpenoids [2,3]. In Solanum lycopersicum (tomato) tricyclene, β-myrcene, limonene, and traces of several other monoterpenoids are also formed . See also EC 126.96.36.199 myrcene synthase, EC 188.8.131.52 (4S)-limonene synthase, EC 184.108.40.206 ()-α-pinene synthase and EC 220.127.116.11 tricyclene synthase.\nLinks to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:\n1. Bohlmann, J., Phillips, M., Ramachandiran, V., Katoh, S. and Croteau, R. cDNA cloning, characterization, and functional expression of four new monoterpene synthase members of the Tpsd gene family from grand fir (Abies grandis). Arch. Biochem. Biophys. 368 (1999) 232-243. [PMID: 10441373]\n2. Huber, D.P.W., Philippe, R.N., Godard, K.-A., Sturrock, R.N. and Bohlmann, J. Characterization of four terpene synthase cDNAs from methyl jasmonate-induced Douglas-fir, Pseudotsuga menziesii. Phytochemistry 66 (2005) 1427-1439. [PMID: 15921711]\n3. Hyatt, D.C. and Croteau, R. Mutational analysis of a monoterpene synthase reaction: altered catalysis through directed mutagenesis of ()-pinene synthase from Abies grandis. Arch. Biochem. Biophys. 439 (2005) 222-233. [PMID: 15978541]\n4. Falara, V., Akhtar, T.A., Nguyen, T.T., Spyropoulou, E.A., Bleeker, P.M., Schauvinhold, I., Matsuba, Y., Bonini, M.E., Schilmiller, A.L., Last, R.L., Schuurink, R.C. and Pichersky, E. The tomato terpene synthase gene family. Plant Physiol. 157 (2011) 770-789. [PMID: 21813655]", "domain": "chemistry", "round": 3} +{"url": "https://www.barnesandnoble.com/w/membrane-fluidity-morris-kates/1117259846", "date": "2019-08-23T18:43:42Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-35/segments/1566027318952.90/warc/CC-MAIN-20190823172507-20190823194507-00302.warc.gz", "language_score": 0.8429877161979675, "token_count": 922, "dump": "CC-MAIN-2019-35", "global_id": "webtext-fineweb__CC-MAIN-2019-35__0__3819245", "lang": "en", "text": "This book represents the proceedings of a Satellite Symposium of the XIth International Congress of Biochemistry on \"Control of Membrane Fluidity\" which was held on July 7, 1979 at the Charles H. Best Institute, University of Toronto, Toronto, Canada. The meeting was organized by M. Kates and A. Kuksis and was supported by the International Congress of Biochemistry. The purpose of the meeting was to review recent progress in many different areas of investigation bearing on the role of lipids in the structural and functional property of the cell membrane commonly referred to as fluidity. The aim was to emphasize the factors controlling membrane fluidity as studied in appropriate in vitro and in vivo experiments. The Symposium included invited review papers and short papers offered by discussants. In assem· bling the book no distinction has been made between the two types of presentations, nor has any significance been attached to the chronological order of their presentation in the Symposium. As a result it was possible to provide a much more coherent and continuous presentation than that available at the meeting.\nTable of ContentsI Measurement of Membrane Lipid Composition and Fluidity.- New Approaches to Lipid Analyses of Lipoproteins and Cell Membranes.- Determination of Molecular Species of Glycerophospholipids by a GC-MS Selected Ion Monitoring Technique.- High-Precision TLC-Densitometry of Membrane Lipids.- The Pulmonary Surfactant: Control of Fluidity at the Air-Liquid Interface.- Fluidity of Membrane Lipids.- II Correlation of Membrane Fluidity with Physiological Activity.- Adaptive Regulation of Membrane Lipid Biosynthesis in Bacilli by Environmental Temperature.- Activity of Membrane-Bound Enzymes (Respiratory Chain) During Adaptation of Fish to Temperature Changes.- Effect of Membrane Lipid Composition on Mobility of Lymphocyte Surface Immunoglobulins.- Plasma Mebrane Mg2+ATPase Activity is Inversely Related to Lipid Fluidity.- Alkaline Phosphatase in Red Cell Membrane: Interconnection of Activities and Membrane Lipid Fluidity.- Membrane Permeability in Porcine Malignant Hyperthermia.- III Fatty Acid Changes Accompanying Physiological Events.- Role of Phospholipid Desaturase in Control of Membrane Fluidity.- Membrane Fluidity and the Activity of Bovine Brain Phospholipid Exchange Protein.- The Regulation of Bacterial Membrane Fluidity by Modification of Phospholipid Fatty Acyl Chain Length.- The Question of Membrane Fluidity in an Anaerobic General Fatty Acid Auxotroph.- Thermal Control of Fatty Acid Synthetase from Brevibacterium ammoniagenes.- Why Do Prokaryotes Regulate Membrane Fluidity?.- Docosahexaenoyl Chains Are Introduced into Phosphatidic Acid During de novo Synthesis in Retinal Microsomes.- IV Phospholipid Changes Accompanying Physiological Events.- Dynamics of Membrane Fatty Acids During Lymphocyte Stimulation by Mitogens.- Phosphatidylinositol as a Source of Diacylglycerol to Promote Membrane Fusion in Exocytosis.- Glycosphingolipid Domain Formation and Lymphoid Cell Activation.- Phospholipid Metabolism of Rat Gastric Mucosa.- Effect of Temperature on the Biosynthesis of 3-sn-Phosphatidylcholine by Fusarium oxysporum F. sp. Lycopersici.- In vivo Modification of Phospholipid Polar Head Groups and Alterations in Membrane Activities and Cellular Events.- V Homeostatic Regulation of Membrane Fluidity.- Homeostatic Control of Membrane Lipid Fluidity in Fusarium.- Homeoviscous Adaptation in Psychrophilic, Mesophilic, and Thermophilic Yeasts.- Regulation of Membrane Fluidity in Anaerobic Bacteria.- Regulation of Membrane Fluidity During Temperature Acclimation by Tetrahymena pyriformis.- Modification of Lipid Composition and Mebrane Fluidity in Tetrahymena.- Regulation of Phospholipid N-Methylation in the Hepatocyte.- Author Index.", "domain": "chemistry", "round": 3} +{"url": "https://psychonautwiki.org/wiki/Talk:Troparil", "date": "2023-12-08T22:28:18Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100779.51/warc/CC-MAIN-20231208212357-20231209002357-00521.warc.gz", "language_score": 0.8513801097869873, "token_count": 1253, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__127695192", "lang": "en", "text": "This page has not been fully approved by the PsychonautWiki administrators.\n|Summary sheet: Troparil|\n|Common names||Troparil, WIN 35,065-2, β-CPT|\n|Systematic name||Methyl (1R,2S,3S,5S)-3-(phenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate|\n|Routes of Administration|\nBeing an only recently introduced research chemical, extremely little is known about the pharmacology, metabolism, and toxicity of troparil in humans. It is highly advised to use harm reduction practices if choosing to use this substance.\nHistory and culture\nThis History and culture section is a stub.\nAs a result, it may contain incomplete or wrong information. You can help by expanding it.\nTroparil primarily acts as a dopamine reuptake inhibitor (DRI). While this effect is a few times more potent as with cocaine, the effect of troparil on serotonin reuptake inhibition is slightly less pronounced.\n|Cocaine||89 ± 4.8||3298 ± 293||1045 ± 89|\n|Dichloropane||0.79 ± 0.09||17.96 ± 0.85||3.13 ± 0.36|\n|Troparil||23 ± 5||920 ± 73||1962 ± 61|\nEffects of troparil are thought to be similar to cocaine, albeit longer lasting.\nDisclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.\nIt is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.\n- Increased heart rate\n- Abnormal heartbeat - This substance consistently raises one's heart rate to abnormally high levels which can be potentially dangerous with prolonged or extremely high dosages.\n- Appetite suppression\n- Bodily control enhancement\n- Increased bodily temperature\n- Increased blood pressure\n- Increased perspiration\n- Pain relief\n- Physical euphoria\n- Teeth grinding\n- Temporary erectile dysfunction\n- The effects which occur during the offset of a stimulant experience generally feel negative and uncomfortable in comparison to the effects which occurred during its peak. This is often referred to as a \"comedown\" and occurs because of neurotransmitter depletion.\nToxicity and harm potential\nThis toxicity and harm potential section is a stub.\nAs a result, it may contain incomplete or even dangerously wrong information! You can help by expanding upon or correcting it.\nThe toxicity and long-term health effects of recreational troparil use has not been studied in any scientific context and the exact toxic dosage is unknown. This is because troparil has very little history of human usage.\nThere is no research demonstrating so, but due to the lack of an ester linkage, troparil might possibly be slightly less cardiotoxic than cocaine. Nevertheless, it still poses a risk to the cardiovascular system and should not be used with a pre-existing heart condition.\nIt is strongly recommended that one use harm reduction practices when using this substance.\nTolerance and addiction potential\nThis dangerous interactions section is a stub.\nAs such, it may contain incomplete or invalid information. You can help by expanding upon or correcting it.\nWarning: Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions (although it is not guaranteed to include all of them).\nAlways conduct independent research (e.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.\nThis legality section is a stub.\nAs such, it may contain incomplete or wrong information. You can help by expanding it.\n- Synthesis and pharmacology of site specific cocaine abuse treatment agents: 8-substituted isotropane (3-azabicyclo[3.2.1]octane) dopamine uptake inhibitors. | http://pubs.acs.org/doi/abs/10.1021/jm020410t\n- Carroll, F. I., Kotian, P., Dehghani, A., Gray, J. L., Kuzemko, M. A., Parham, K. A., Abraham, P., Lewin, A. H., Boja, J. W., Kuhar, M. J. (January 1995). \"Cocaine and 3.beta.-(4'-Substituted phenyl)tropane-2.beta.-carboxylic Acid Ester and Amide Analogs. New High-Affinity and Selective Compounds for the Dopamine Transporter\". Journal of Medicinal Chemistry. 38 (2): 379–388. doi:10.1021/jm00002a020. ISSN 0022-2623.\n- Carroll, F. I., Blough, B. E., Nie, Z., Kuhar, M. J., Howell, L. L., Navarro, H. A. (1 April 2005). \"Synthesis and Monoamine Transporter Binding Properties of 3β-(3',4'-Disubstituted phenyl)tropane-2β-carboxylic Acid Methyl Esters\". Journal of Medicinal Chemistry. 48 (8): 2767–2771. doi:10.1021/jm040185a. ISSN 0022-2623.", "domain": "chemistry", "round": 3} +{"url": "https://www.thermofisher.com/antibody/product/ROCK1-Antibody-1H4-Monoclonal/MA5-17165", "date": "2017-06-23T01:59:11Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-26/segments/1498128319943.55/warc/CC-MAIN-20170623012730-20170623032730-00527.warc.gz", "language_score": 0.8312917351722717, "token_count": 419, "dump": "CC-MAIN-2017-26", "global_id": "webtext-fineweb__CC-MAIN-2017-26__0__125889714", "lang": "en", "text": "|Tested species reactivity||Human|\n|Host / Isotype||Mouse / IgG1|\n|Immunogen||Purified recombinant fragment of human ROCK1 expressed in E. Coli.|\n|Storage buffer||PBS with 0.5% proprietary stabilizer|\n|Contains||0.05% sodium azide|\n|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|\n|Tested Applications||Dilution *|\n|Western Blot (WB)||1:500 - 1:2000|\n* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.\nMA5-17165 targets ROCK1 in pep-ELISA and WB applications and shows reactivity with Human samples.\nThe MA5-17165 immunogen is purified recombinant fragment of human ROCK1 expressed in E. Coli.\nMA5-17165 detects ROCK1 which has a predicted molecular weight of approximately 158kDa.\nThis gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity.\nFor Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.", "domain": "chemistry", "round": 3} +{"url": "https://www.routledge.com/Materials-Science-of-Polymers-Plastics-Rubber-Blends-and-Composites/Haghi-Castro-Thomas-Sivakumar-Mercader/p/book/9781771880664", "date": "2019-06-17T21:12:11Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-26/segments/1560627998580.10/warc/CC-MAIN-20190617203228-20190617225228-00422.warc.gz", "language_score": 0.7701489925384521, "token_count": 1305, "dump": "CC-MAIN-2019-26", "global_id": "webtext-fineweb__CC-MAIN-2019-26__0__170524908", "lang": "en", "text": "Apple Academic Press\n370 pages | 255 B/W Illus.\nTechnical and technological development demands the creation of new materials that are stronger, more reliable, and more durable—materials with new properties. This book skillfully blends and integrates polymer science, plastic technology, and rubber technology to highlight new developments and trends in advanced polyblends. The fundamentals of polymerization, polymer characteristics, rheology and morphology, as well as composition, technology, testing and evaluation of various plastics, rubbers, fibers, adhesives, coatings, and composites are comprehensively presented in this informative volume.\nThe book presents the developments of advanced polyblends and the respective tools to characterize and predict the material properties and behavior. It provides important original and theoretical experimental results that use non-routine methodologies often unfamiliar to many readers. Furthermore chapters on novel applications of more familiar experimental techniques and analyses of composite problems are included, which indicate the need for the new experimental approaches that are presented.\nThis new book:\n• Provides an up-to-date and thorough exposition of the present state of the art of polyblends and composites\n• Familiarizes the reader with new aspects of the techniques used in the examination of polymers, emphasizing plastic technology and rubber technology\n• Describes the types of techniques now available to the polymer chemist and technician and discusses their capabilities, limitations, and applications\n• Provides a balance between materials science and the mechanics aspects, basic and applied research, and high-technology and high-volume (low-cost) composite development\nEntrepreneurs and professionals engaged in production of as well as research and development in polymers will find the information presented here valuable and informative.\nA Detailed Review on Characteristics, Application and Limitation of Amorphous Glassy Polymers As Natural Nano-Composites; G. V. Kozlov, I. V. Dolbin, Jozef Richert, O. V. Stoyanov, and G. E. Zaikov\nStructure of Graphitic Carbons: a Comprehensive Review; Heinrich Badenhorst\nRadiation Crosslinking of Acrylonitrile-Butadiene Rubber; Katarzyna Bandzierz, Dariusz M. Bielinski, Adrian Korycki, and Grazyna Przybytniak\nRubber Vulcanizates Containing Plasmochemically Modified Fillers; Dariusz M. Bieliński, Mariusz Siciński, Jacek Grams, and Michał Wiatrowski\nModification of the Indian Rubber in the Form of Latex with Ozone; L. A. Vlasova, P. T. Poluektov, S. S. Nikulin, and V. M. Misin\nInfluence of The Structure of Polymer Material on Modification of The Surface Layer of Iron Counterface In Tribological Contact; Dariusz M. Bieliński, Mariusz Siciński, Jacek Grams, Michał Wiatrowski\nBoron Oxide as a Fluxing Agent for Silicone Rubber-Based Ceramizable Composites; R. Anyszka, D. M. Bieliński, and Z. Pędzich\nApplication of Micro-Dispersed Silicon Carbide Along with Slurries as a Functional Filler in Fire and Heat Resistant Elastomer Compositions; V. S. Liphanov, V. F. Kablov, S. V. Lapin, V. G. Kochetkov, O. M. Novopoltseva, and G. E. Zaikov\nThermal Stability of Elastic Polyurethane; I. A. Novakov, M. A. Vaniev, D. V. Medvedev, N. V. Sidorenko, G. V. Medvedev, and D. O. Gusev\nPan/Nano–Тіо2–S Composites : Physico–Chemical Properties; M. M. Yatsyshyn, A. S. Kun’ko, and O. V. Reshetnyak\nViscoelastic Properties of the Polystyrene; Yu. G. Medvedevskikh, O. Yu. Khavunko, L. I. Bazylyak, and G. E. Zaikov\nNanostructured Polymeric Composites Filled with Nanoparticles; A. K. Mikitaev, A. Yu. Bedanokov, M. A. Mikitaev\nStructure, Properties and Application of Dendritic Macromolecules in Various Fields: Molecular Simulation Techniques in Hyperbranched Polymer and Dendrimers; M. Hasanzadeh and B. Hadavi Moghadam\nA Study on Influence of Electrospinning Parameters on the Contact Angle of the Electrospun Pan Nanofiber Mat Using Response Surface Methodology (Rsm) and Artificial Neural Network (Ann); B. Hadavi Moghadam and M. Hasanzadeh\nFabrication and Characterization of the Metal Nano-Sized Branched Structures and the Composite Nanostructures Grown on Insulator Substrates by the Ebid Process; Guoqiang Xie, Minghui Song, Kazuo Furuya, and Akihisa Inoue\nA Case Study on Hyperbranched Polymers; Ramin Mahmoodi, Tahereh Dodel, Tahereh Moieni, and Mahdi Hasanzadeh\nA Study on Network of Sodium Hyaluronate with Nano-Knots Junctions; Shin-Ichi Hamaguchi and Toyoko Imae\nThe Magnetic Photocatalyst Conversion to the Magnetic Dye-Adsorbent Catalyst via Hydrothermal Followed by Typical Washing and Thermal Treatments; Satyajit Shukla\nSolid Polymer Fuel Cell: A Three-Dimensional Computation Model and Numerical Simulations; Mirkazem Yekani, Meysam Masoodi, Nima Ahmadi, Mohamad Sadeghi Azad, and Khodadad Vahedi", "domain": "chemistry", "round": 3} +{"url": "https://azd6482.com/tag/sema3f/", "date": "2022-10-06T21:31:35Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-40/segments/1664030337855.83/warc/CC-MAIN-20221006191305-20221006221305-00344.warc.gz", "language_score": 0.9409627318382263, "token_count": 1043, "dump": "CC-MAIN-2022-40", "global_id": "webtext-fineweb__CC-MAIN-2022-40__0__108614441", "lang": "en", "text": "Proteins, as professionals of genes’ guidelines, are in charge of cellular phenotypes. with 245 protein and their genes demonstrated >1.5-fold change in buy 16561-29-8 expression level. Gene ontology enrichment evaluation revealed that up-regulated protein were more involved with cell movement and adhesion than down-regulated protein. Furthermore, up-regulated proteins had been more likely to become situated in nucleus and vesicles. Further confirmation tests with IHC verified differential expression degrees of 5 protein (S100 calcium-binding proteins A9, annexin A3, nicotinamide phosphoribosyltransferase, carboxylesterase 2 and calcium mineral activated chloride route A1) between CRC and regular tissues. Besides, traditional western blot demonstrated a stepwise boost of annexin A3 great quantity in regular colorectal mucosa, cRC and adenoma tissues. ELISA outcomes revealed considerably higher serum degrees of S100 calcium-binding proteins A9 and annexin A3 in CRC individuals than healthy settings, validating diagnostic worth of the proteins. Cell tests showed that inhibition of annexin A3 could suppress CRC cell aggressiveness and proliferation. S100 calcium-binding proteins buy 16561-29-8 A9, annexin A3, nicotinamide phosphoribosyltransferase, carboxylesterase 2 and calcium mineral activated chloride route A1 were potential biomarkers of colorectal tumor probably. Annexin A3 was a very important therapeutic focus on of CRC potentially. tests demonstrated that inhibition of ANXA3 with shRNA plasmid could decrease CRC cell aggressiveness and proliferation, which indicated that ANXA3 may be a valuable restorative focus Sema3f on of CRC. Further extensive research is anticipated. NAMPT, also called pre-B-cell colony-enhancing aspect 1 (PBEF1) or visfatin, can be an enzyme owned by the grouped category of glycosyltransferases. Nicotinamide adenine dinucleotide (NAD), among the essential metabolites necessary for cell success, has three primary producing pathways including two salvage pathways. In comparison to regular cells, tumor cells are even more dependent on principal salvage pathway . As the rate-limiting enzyme in principal salvage pathway, NAMPT buy 16561-29-8 appearance level can significantly influence NAD fat burning capacity and NAD reliant cellular procedures in tumor cells . Over-expression of NAMPT continues to be seen in many malignancies including colorectal, ovarian, breasts, et al . To time, several novel and powerful inhibitors concentrating on NAMPT have already been synthesized which have proven anti-tumor efficiency in tumor versions and . CES2, a known person in alpha/beta flip hydrolase family members, can be an enzyme in charge of the hydrolysis of ester- and amide-bond-containing medications. Its specific features never have been elucidated however. Research show that some anti-cancer medications such as for example 5-FU can induce CES2 enhance and appearance cell-killing activity [21, 22]. We noticed reduced appearance of CES2 in CRC tissue compared to matched up regular mucosa, which indicated that CES2 could be a poor biomarker of CRC risk. CLCA1 is one of the calcium mineral delicate chloride conductance proteins family. Researchers have got observed considerably lower appearance of CLCA1 in colorectal cancers tissues weighed against regular tissues. And low degree of CLCA1 in CRC may anticipate disease relapse and poor prognosis [23, 24]. Our outcomes had been in concordance with prior studies. However the molecular system how CLCA1 affects cancer tumor cell differentiation and proliferation continues to be unidentified. Our research integrated high-throughput proteomics with genomics to recognize applicant biomarkers buy 16561-29-8 of CRC. To your knowledge, aside from our research, there’s been only one research applying integrative proteomics with genomics to determine proteogenomic characterization of CRC up to now . Zhang and his co-workers executed a scholarly research to execute integrated proteogenomic analyses of CRC, and discovered five main proteomic subtypes that connected with scientific features . In regards to to our research, outcomes of proteomics had been in keeping with that of genomics extremely, displaying 245 differential proteins between CRC and matched normal mucosa significantly. Further confirmation experiments with tissue indicated five protein buy 16561-29-8 (S100A9, ANXA3, NAMPT, CES2 and CLCA1) to become potential biomarkers of CRC. But limitations such as for example little test lack and sizes of tests with body system liquid been around inside our research. Large-scale potential researches are warranted Additional. MATERIALS AND Strategies Samples and individual characteristics Matched CRC and adjacent regular tissues had been surgically gathered from 94 sufferers admitted in the next Affiliated Medical center, Zhejiang University College of Medication between.", "domain": "chemistry", "round": 3} +{"url": "https://keio.pure.elsevier.com/ja/publications/amniotic-membrane-hybridized-pva-artificial-cornea", "date": "2023-03-22T00:30:59Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-14/segments/1679296943747.51/warc/CC-MAIN-20230321225117-20230322015117-00210.warc.gz", "language_score": 0.8370831608772278, "token_count": 348, "dump": "CC-MAIN-2023-14", "global_id": "webtext-fineweb__CC-MAIN-2023-14__0__96173389", "lang": "en", "text": "Collagen immobilized PVA Hydrogel has been developed as a artificial corneal materials and demonstrated the formation of the corneal epithelium layer on the surface in rabbit model. In this study, to improve the in vivo stability, amniotic membrane hybridized PVA artificial cornea is newly synthesized and evaluated the corneal epithelium formation on the surface using rabbit model. The amniotic membrane hybridized PVA was successfully prepared and it was stable in PBS at least two months. Corneal epithelium was stratification on the amniotic membrane hybridized PVA in in vitro. The amniotic membrane hybridized PVA was completely epithelialized within two weeks and the hybrid artificial corne a kept the transparency. The long-term stability test will be required.\n|出版ステータス||Published - 2005 12月 1|\n|イベント||54th SPSJ Symposium on Macromolecules - Yamagata, Japan|\n継続期間: 2005 9月 20 → 2005 9月 22\n|Other||54th SPSJ Symposium on Macromolecules|\n|Period||05/9/20 → 05/9/22|\nASJC Scopus subject areas", "domain": "chemistry", "round": 3} +{"url": "https://smadsignaling.com/9-fold-increase-in-sa113-versus-sa113%CE%94isaberm-figure-5-isab-bi/", "date": "2020-07-16T15:36:51Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-29/segments/1593657172545.84/warc/CC-MAIN-20200716153247-20200716183247-00202.warc.gz", "language_score": 0.9282407164573669, "token_count": 693, "dump": "CC-MAIN-2020-29", "global_id": "webtext-fineweb__CC-MAIN-2020-29__0__67030985", "lang": "en", "text": "9-fold increase in SA113 versus SA113ΔisaB::erm. Figure 5 IsaB binds eDNA on the cell surface. S. aureus strains 10833, Sa113, and their isogenic isaB deletion mutants were assayed for their ability to bind to a Buparlisib fluorescently labeled oligonucleotide. The y-axis\nrepresents the relative light units. Wildtype fluorescence levels were significantly higher with a probability value of p = 0.006 for 10833 versus 10833ΔisaB::ern and Sa113 versus Sa113ΔisaB::erm (Student’s unpaired T test). Deletion of isaB did not affect biofilm formation Isogenic isaB deletion mutants exhibited no apparent growth defects under any conditions tested (data not shown). Microtiter assays for biofilm formation in a variety of media did not reveal any contribution of IsaB to biofilm formation and there was KU55933 datasheet no significant difference between 10833ΔisaB::erm and SA113ΔisaB::erm and their respective wildtype parental strains in TSB, TSBG, BHI, BHIG, or LB (Figure 6). Surprisingly, Selleck EPZ6438 although there was no obvious visible difference, there was a statistically significant increase in the OD595 nm in the isaB deletion mutants of both strains\nin LBG. This was consistent between technical and biologic replicates. As extracellular DNA has been shown to affect biofilm development in flow cells , we also tested the wildtype and mutant strains under flow conditions. However, there were no observable differences in biofilm formation or maintenance between the isaB deletion mutants and their respective wildtype strains (data not shown). Figure 6 Microtiter plate assay for biofilm formation. Strains SA113 and 10833 and their isogenic isaB deletion mutants were screened for their ability to form biofilms in different media; TSB, TSB+1% glucose and 3.5% NaCl, BHI, BHI+1% glucose, LB, Histamine H2 receptor or LB+1% glucose. A. Safranin-stained biofilms and B. Average OD595 nm values of 8 wells from three separate experiments (24 values) of solubilized safranin-stained biofilms. Deletion of isaB did not reduce biofilm formation under any conditions tested but there\nwas a statistically significant increase in OD595 nm in the absence of isaB in LBG. Discussion Immunodominant antigen B (IsaB) was first described by Lorenz et al for its immunogenicity in patients recovering from septicemia . While IsaB has been referred to as a virulence factor [7, 9], the amino acid sequence does not display significant homology to other proteins of known function, and to date its function remains unknown. In this study we serendipitously discovered the nucleic acid-binding activity of IsaB in a RNA Affinity Chromatography assay designed to identify factors that regulate ica expression post-transcriptionally. However, further experiments indicated that while IsaB binds the transcript, it does not affect ica expression, and does not play a significant role in the post-transcriptional regulation of ica.", "domain": "chemistry", "round": 3} +{"url": "https://www.mendeley.com/papers/differential-interaction-glimepiride-glibenclamide-%CE%B2cell-sulfonylurea-receptor-ii-photoaffinity-labe/", "date": "2019-01-17T00:15:32Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-04/segments/1547583658662.31/warc/CC-MAIN-20190117000104-20190117022104-00303.warc.gz", "language_score": 0.8644863367080688, "token_count": 892, "dump": "CC-MAIN-2019-04", "global_id": "webtext-fineweb__CC-MAIN-2019-04__0__228756789", "lang": "en", "text": "Glimepiride is a novel sulfonylurea for the treatment of type II-diabetic patients exhibiting different receptor binding kinetics to β-cell membranes with 8-9-fold higher koffrate and 2.5-3-fold higher konrate compared to glibenclamide (see accompanying paper (Müller, G. et al. (1994) Biochim. Biophys. Acta 1191, 267-277)). To elucidate the molecular basis for this differential behaviour of glimepiride and glibenclamide, direct photoaffinity labeling studies using β-cell tumor membranes were performed. [3H]Glimepiride was specifically incorporated into a membrane polypeptide of Mr= 65000 under conditions, which led to predominant labeling of a 140 kDa protein by [3H]glibenclamide (Kramer, W. et al. (1988) FEBS Lett. 229, 355-359). Labeling of the 140 kDa protein by [3H]glibenclamide was inhibited by unlabeled glimepiride and, vice versa, glibenclamide inhibited labeling of the 65 kDa protein by [3H]glimepiride. The 65 kDa protein was also specifically photolabeled by the sulfonylurea [125I]35623, whereas an 4-azidobenzoyl derivative of glibenclamide, N3-[3H]33055, exclusively labeled a 33 kDa protein. Competitive Scatchard analysis of [3H]glimepiride-binding and [3H]glibenclamide-binding to RINm5F cell membranes using glibenclamide and glimepiride, respectively, as heterologous displacing compounds yielded non-linear plots. These findings may be explained by cooperative interactions between the 140 and 65 kDa sulfonylurea-binding proteins. The possibility that sulfonylureas of different structure have different access to the 140 and 65 kDa receptor proteins due to the β-cell membrane barrier was investigated by photoaffinity labeling of solubilized β-cell membrane proteins. Interestingly, solubilization of β-cell tumor membranes led to a shift of specific [3H]glibenclamide binding from the 140 kDa to the 65 kDa binding protein, exclusively, and to an increased labeling of the 65 kDa protein by [3H]glimepiride. The labeling of a unique protein is in agreement with similar Kdvalues measured for both sulfonylurcas upon solubilization of β-cell tumor and RINm5F cell membranes (see accompanying paper). Furthermore, competitive Scatchard plots of [3H]glimepiride binding to solubilized RINm5F cell membrane proteins in the presence of glibenclamide and vice versa approximate linearity suggesting loss of cooperativity between the 140 kDa glibenclamide-binding and 65 kDa glimepiride-binding proteins upon solubilization. The physiological significance of the differential interaction of glimepiride and glibenclamide with different binding proteins was also substantiated by photoaffinity labeling of RINm5F cells leading to labeling of a 140 kDa protein by [3H]glibenclamide and of a 65 kDa protein by [3H]glimepiride. In conclusion, this report presents the first evidence that different sulfonylurea drugs bind to different components of the sulfonylurea receptor complex which are characterized by different accessibility for the drugs. © 1994.\nKramer, W., Müller, G., Girbig, F., Gutjahr, U., Kowalewski, S., Hartz, D., & Summ, H. D. (1994). Differential interaction of glimepiride and glibenclamide with the β-cell sulfonylurea receptor II. Photoaffinity labeling of a 65 kDa protein by [3H]glimepiride. BBA - Biomembranes, 1191(2), 278–290. https://doi.org/10.1016/0005-2736(94)90178-3", "domain": "chemistry", "round": 3} +{"url": "https://grubersystems.com/products/equipment/metering/metergh/ghpc", "date": "2021-01-19T05:43:26Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-04/segments/1610703517966.39/warc/CC-MAIN-20210119042046-20210119072046-00624.warc.gz", "language_score": 0.8854768872261047, "token_count": 515, "dump": "CC-MAIN-2021-04", "global_id": "webtext-fineweb__CC-MAIN-2021-04__0__111977083", "lang": "en", "text": "Application: Metering of either large or small aggregate bulk filler material for continuous casting of polymer concrete products.\nThe Polymer Concrete Ground Hopper is generally used in conjunction with Gruber Systems’ Autocaster Ultra/PC (Polymer Concrete) continuous casting system or other systems. Ground Hoppers provide a longer term supply of fillers to the metering hoppers mounted on top of the Autocaster system - so that the continuous casting capability of the Autocaster is not interrupted by the need to resupply the metering hoppers.\nShown at right are two Gruber Systems' Polymer Concrete Ground Hoppers, supplying a Gruber Systems' Autocaster Ultra/PC (Polymer Concrete) continuous casting system with Aggregate Bulk Fillers. Each filler supply in turn keeps the metering hoppers on the top of the Autocaster continuously supplied with aggregate to enable continous operation of the casting system.\nGround Hopper Benefits:\nPrecise, automated metering eliminates waste\nEliminate labor costs of manual bulk material handling and tank filling\nNo overhead mountings\nCompliments a continuous casting system (like the Gruber Autocaster Ultra Polymer Concrete version) by automating the transport of any required filler material.\nGruber offers different Ground Hoppers that are specifically designed for transferring Polymer Concrete fillers:\nAuger based - three different options for fine particles, small aggregates, or larger aggregates\nBelt-Drive based - for the largest aggregates such as stones\nPolymer Concrete Ground Hoppers Include:\nDesigned to handle the demanding requirements of metering large rock or highly abrasive aggregates for polymer concrete and other specialized cast polymer manufacturing applications.\nAuger-based Ground Hopper configured for processing of larger aggregates such as quartz, sand, pea gravel or small rock of up to 3/8” (7 mm) diameter often used in Polymer Concrete and other cast polymer manufacturing applications.\nAuger-based Ground Hopper configured for processing of smaller aggregates such as sand, small pea gravel, as well as powders such as calcium carbonate or dolomite often used in Polymer Concrete and other cast polymer manufacturing applications.\nFor lightweight powders such as Calcium Carbonate blends or ATH blends, choose from our Standard Auger-driven Ground Hopper, or a Pneumatic Transport Ground Hopper that offers some advantages over the auger-driven model.", "domain": "chemistry", "round": 3} +{"url": "https://m.scirp.org/papers/37161", "date": "2022-08-16T18:34:25Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882572515.15/warc/CC-MAIN-20220816181215-20220816211215-00179.warc.gz", "language_score": 0.7444761991500854, "token_count": 1602, "dump": "CC-MAIN-2022-33", "global_id": "webtext-fineweb__CC-MAIN-2022-33__0__205305724", "lang": "en", "text": "Molecular modeling as a tool in studying peptide-substrate interactions provides insight on peptide adsorption conformation, adsorption energy, and stability of the peptide-inorganic interface. This work investigates the hydration and interaction of cell-adhesion peptides, specifically RGD and YIGSR, with the hydroxyapatite surface and TiO2 surface in cluster and periodic boundary condition approaches. The comparison of adsorption energies of RGD and YIGSR on both Hydroxyapatite (HA) and TiO2 surfaces reveals the similarities in adsorption energy and orientation pattern of peptides on both surfaces. The models demonstrate that initial peptide orientation affects adsorption energy for both. YIGSR is consistently more strongly adsorbed to HA-(001) surfaces and steps than RGD for both the surfaces. In addition, RGD maintained its “hairpin”-like structure during adsorption on a flat HA-(001) surface, and a slightly “relaxed hairpin” structure on TiO2 (110) surface. Adsorption energies of RGD on TiO2 (110) surface are significantly more favorable compared to HA-(001) surface, suggesting potential role of TiO2 as biomedical implants when tissue regeneration occurs via cell signaling.\n S. P. Massia and J. A. Hubbell, “Covalent Surface Immobilization of Arg-Gly-Asp-and Tyr-Ile-Gly-Ser-Arg-Containing Peptides to Obtain Well-Defined Cell-Adhesive Substrates,” Analytical Biochemistry, Vol. 187, No. 2, 1990, pp. 292-301.\n Y. Iwamoto, F. A. Robey, J. Graf, M. Sasaki, H. K. Kleinman, Y. Yamada and G. R. Martin, “YIGSR, a Synthetic Lamininpentapeptide, Inhibits Experimental Metastasis Formation,” Science, Vol. 238, No. 4830, 1987, pp. 1132-1134.\n W. H. Kim, H. W. Schnaper, M. Nomizu, Y. Yamada and H. K. Kleinman, “Apoptosis in Human Fibrosarcoma Cells Is Induced by a Multimeric Synthetic Tyr-Ile-Gly-SerArg (YIGSR)-Containing Polypeptide from Laminin,” Cancer Research, Vol. 54, No. 18, 1994, pp. 5005-5010.\n E. Ruoslahti, “RGD and Other Recognition Sequences for Integrins,” Annual Review of Cell and Developmental Biology, Vol. 12, 1996, pp. 697-715. http://dx.doi.org/10.1146/annurev.cellbio.12.1.697\n M. Kantlehner, D. Finsinger, J. Meyer, P. Schaffner, A. Jonczyk, B. Diefenbach, B. Nies and H. Kessler, “Selective RGD-Mediated Adhesion of Osteoblasts at Surfaces of Implants,” Angewandte Chemie International Edition, Vol. 38, No. 4, 1999, pp. 560-562. http://dx.doi.org/10.1002/(SICI)1521-3773(19990215)38:4<560::AID-ANIE560>3.0.CO;2-F\n M. Gilbert, W. J. Shaw, J. R. Long, K. Nelson, G. P. Drobny, C. M. Giachelli and P. S. Stayton, “Chimeric Peptides of Statherin and Osteopontin That Bind Hydroxyapatite and Mediate Cell Adhesion,” Journal of Biological Chemistry, Vol. 275, No. 21, 2000, pp. 16213-16218.\n U. Becker, S. Biswas, T. Kendall, P. Risthaus, C. V. Putnis and C. M. Pina, “Interactions between Mineral Surfaces and Dissolved Species: From Monovalent Ions to Complex Organic Molecules,” American Journal of Science, Vol. 305, No. 6-8, 2005, pp. 791-825.\n C. Boiziau, S. Leroy, C. Reynaud, G. Lecayon, C. Legressus and P. Viel, “Elementary Mechanisms in the Interaction of Organic-Molecules with Mineral Surfaces,” Journal of Adhesion, Vol. 23, No. 1, 1987, pp. 21-44.\n N. H. de Leeuw, “A Computer Modeling Study of the Uptake and Segregation of Fluoride Ions at the Hydrated Hydroxyapatite (0001) Surface: Introducing a Ca10(PO4)6OH2 Potential Model,” Physical Chemistry Chemical Physics, Vol. 6, No. 8, 2004, pp. 1860-1866.\n D. Mkhonto and N. H. de Leeuw, “A Computer Modeling Study of the Effect of Water on the Surface Structure and Morphology of Fluorapatite: Introducing a Ca10(PO4)6F2 Potential Model,” Journal of Materials Chemistry, Vol. 12, No. 9, 2002, pp. 2633-2642.\n A. K. Rappe, C. J. Casewit, K. S. Colwell, W. A. Goddard and W. M. Skiff, “UFF, a Full Periodic-Table Force Field for Molecular-Mechanics and Molecular-Dynamics Simulations,” Journal of the American Chemical Society, Vol. 114, No. 25, 1992, pp. 10024-10035. http://dx.doi.org/10.1021/ja00051a040\n S. Biswas and U. Becker, “Molecular Modeling of Cell Adhesion Peptides on Hydroxyapatite Surfaces and Surface Steps: Application in Bone Tissue Engineering and Biomimetics,” 3rd International Conference on Chemical, Biological and Environment Sciences (ICCEBS’2013), Kuala Lumpur, 8-9 January 2013, pp. 59-63.\n L. Zhang and T. J. Webster, “Nanotechnology and Nanomaterials: Promises for Improved Tissue Regeneration,” Nano Today, Vol. 4, No. 1, 2009, pp. 66-80. http://dx.doi.org/10.1016/j.nantod.2008.10.014\n M. J. Webber, J. A. Kessler and S. I. Stupp, “Emerging Peptide Nanomedicine to Regenerate Tissues and Organs,” Journal of Internal Medicine, Vol. 267, No. 1, 2010, pp. 71-88. http://dx.doi.org/10.1111/j.1365-2796.2009.02184.x", "domain": "chemistry", "round": 3} +{"url": "https://www.scientific.net/MSF.498-499.244", "date": "2017-10-19T21:59:14Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-43/segments/1508187823478.54/warc/CC-MAIN-20171019212946-20171019232946-00136.warc.gz", "language_score": 0.9241776466369629, "token_count": 370, "dump": "CC-MAIN-2017-43", "global_id": "webtext-fineweb__CC-MAIN-2017-43__0__129685312", "lang": "en", "text": "High-Speed Steels Produced by Conventional Casting, Spray Forming and Powder Metallurgy\nPowder metallurgy (PM) and spray forming (SF) have been reported as important alternative routes for tool steel production. The ability to promote refined and more uniform microstructures is their main advantages, leading to improved properties and larger isotropy. While PM application is a completely established technology, the SF process may be considered as a not totally explored field. Therefore, the present work aimed to study the potential of both processes, focusing at high-speed steel (HSS) production. AISI M3:2 highspeed steel was produced by conventional casting, spray forming and powder metallurgy. Conventional ingots and a 400 mm diameter SF billet were rolled to small diameter bars, with cross section around 110 mm. The PM material was evaluated in the as-HIPed condition, in comparative diameters. Large diameter HSS bars are used mainly in cutting tools, but are also applied in cold work tooling when high wear resistance is required. In the present characterisation, microstructures and bend test analysis were used, both in transverse and longitudinal directions. The results show that the as-HIPed PM material presents finer and more uniform carbide distribution, leading to a complete isotropy and higher toughness than conventional steel. In the SF material, carbides are also finer, have good distribution and the isotropy is considerably higher than that for conventional HSS.\nLucio Salgado and Francisco Ambrozio Filho\nR. A. Mesquita and C. A. Barbosa, \"High-Speed Steels Produced by Conventional Casting, Spray Forming and Powder Metallurgy\", Materials Science Forum, Vols. 498-499, pp. 244-250, 2005", "domain": "chemistry", "round": 3} +{"url": "https://galusaustralis.com/2019/11/39630/rare-earth-elements-market-to-represent-significant-revenue-growth-by-2026-top-players-minmetals-rare-earth-co-ltd-alkane-resources-ltd-arafura-resources-lynas-corporation-ltd/", "date": "2021-01-21T01:44:55Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-04/segments/1610703522150.18/warc/CC-MAIN-20210121004224-20210121034224-00753.warc.gz", "language_score": 0.8853008151054382, "token_count": 1543, "dump": "CC-MAIN-2021-04", "global_id": "webtext-fineweb__CC-MAIN-2021-04__0__234059959", "lang": "en", "text": "Global Rare Earth Elements Industry 2019 Market Research Report focuses on price, sales, revenue and growth rate of each type, as well as the types and each type price of key manufacturers, through interviewing key manufacturers. Second on basis of segments by manufacturers, this report focuses on the sales, price of each type, average price of Credit Insurance, revenue and market share, for key manufacturers.\nGlobal rare earth elements market is expected to register a substantial CAGR of 9.20% in the forecast period of 2019-2026. The report contains data from the base year of 2018 and the historic year of 2017. This rise in market value can be attributed to the significant rise of demands from the various emerging locations of the world.\nFor In depth Information Get Sample Copy of this [email protected] https://www.databridgemarketresearch.com/request-a-sample/?dbmr=global-rare-earth-elements-market\nGlobal Rare Earth Elements Market By Element (Cerium, Neodymium, Lanthanum, Dysprosium, Terbium, Erbium, Europium, Gadolinium, Holmium, Lutetium, Praseodymium, Promethium, Samarium, Thulium, Ytterbium, Yttrium, Scandium, Others), Application (Catalysts, Ceramics, Phosphors, Glass & Polishing, Metallurgy, Magnets, Others), Geography (North America, Europe, Asia-Pacific, South America, Middle East and Africa) – Industry Trends and Forecast to 2026\nComplete report on Global Rare Earth Elements Market Research Report 2019-2026 spread across 350 Pages, profiling Top companies and supports with tables and figures\nMarket Definition: Global Rare Earth Elements Market\nRare earth elements are various chemical elements present in the periodic table. These elements aren’t necessarily rare to find, although their presence is spread across the entire earth in an even manner therefore their availability in a particular location is limited, which results in extraction of these elements from mines quite complicated.\nKey Questions Answered in Global Rare Earth Elements Market Report:-\nOur Report offers:-\n- What will the market growth rate, Overview and Analysis by Type of Global Rare Earth Elements Market in 2026?\n- What are the key factors driving, Analysis by Applications and Countries Global Rare Earth Elements Market?\n- What are Dynamics, This Overview Includes Analysis of Scope, and price analysis of top Vendors Profiles of Global Rare Earth Elements Market?\n- Who are Opportunities, Risk and Driving Force of Global Rare Earth Elements Market?\n- Who are the opportunities and threats faced by the vendors in Global Rare Earth Elements Market? Business Overview by Type, Applications, Gross Margin and Market Share\n- What are the Global Rare Earth Elements Market opportunities, market risk and market overview of the Market?\nRequest for Detailed TOC: https://www.databridgemarketresearch.com/toc/?dbmr=global-rare-earth-elements-market\nTop Key Players:\n- Minmetals Rare Earth Co., Ltd.;\n- Alkane Resources Ltd;\n- ARAFURA RESOURCES;\n- Lynas Corporation Ltd;\n- China Rare Earth Holdings Limited;\n- Avalon Advanced Materials Inc.;\n- IREL(INDIA) LIMITED;\n- Greenland Minerals Ltd.;\n- Rare Element Resources Ltd.;\n- Frontier Rare Earths Limited;\n- Canada Rare Earth Corporation;\n- Iluka Resources Limited;\n- Northern Minerals;\n- Krakatoa Resources Limited;\n- Ucore Rare Metals Inc.;\n- Namibia Critical Metals Inc.\n- among others.\n- Requirement of rare earth elements for the implementation and utilization of green technology worldwide; this factor is expected to propel the growth of the market\n- Focus of various organizations and companies on enhancing their understanding and technologies for rare earth elements; this factor is expected to foster growth of the market\n- Increased application area of these elements due to the rising demand for electric and hybrid vehicles also acts as a market driver\n- High demand associated with these elements due to their application as catalysts in various production activities will drive the market growth\n- Concerns regarding the increasing presence of illegal activities for extraction of rare earth elements from the different regions; this factor is expected to act as a restraint to the growth of the market\n- Lack of consistent supply to various end-users and applicable sectors is expected to hamper the market growth\n- Inequality of demand and supply quantities due to the trade wars between supplier of rare earth elements worldwide will restrict the growth of this market\nKey Developments in the Market:\n- In May 2019, Blue Line Corp. announced that they had entered into a partnership with Lynas for the establishment of a processing facility for rare earth elements. This facility will be located at Texas, United States and will help establish them as the first and only company capable of processing and separating rare earth elements outside the China region. This will ensure that the various organizations can meet the significant demands and applications of rare earth from the various end-users\n- In November 2018, Arafura Resources Ltd. announced the establishment of “Nolans Project” which will help them in the production of “neodymium-praseodymium (NdPr)” element. Nolans project located in Northern Territory of Australia region is expected to help supply the ten percent demand for this element worldwide when it will be in full production, expected to be by 2020 at a highly cost-effective cost. The company has also finalized the location for the processing and separation plant for their rare earth element production which will be in Australia\nInquire Before Buying @ https://www.databridgemarketresearch.com/inquire-before-buying/?dbmr=global-rare-earth-elements-market\nCustomize report of “Global Rare Earth Elements Market” as per customers requirement also available.\nGlobal Rare Earth Elements Market is segmented on the basis of\nMarket Segmentations in Details:\n- Glass & Polishing\n- United Kingdom\n- Rest of Europe\n- South Korea\n- Rest of Asia Pacific\n- Rest of South America\nMiddle East & Africa\n- South Africa\n- Saudi Arabia\n- Rest of MEA\nCompetitive Analysis: Global Rare Earth Elements Market\nGlobal rare earth elements market is highly fragmented and the major players have used various strategies such as new product launches, expansions, agreements, joint ventures, partnerships, acquisitions, and others to increase their footprints in this market. The report includes market shares of rare earth elements market for Global, Europe, North America, Asia-Pacific, South America and Middle East & Africa.\nSpeak to Author of the report @ https://www.databridgemarketresearch.com/speak-to-analyst/?dbmr=global-rare-earth-elements-market\nAbout Data Bridge Market Research:\nData Bridge Market Research set forth itself as an unconventional and neoteric Market research and consulting firm with unparalleled level of resilience and integrated approaches. We are determined to unearth the best market opportunities and foster efficient information for your business to thrive in the market. Data Bridge endeavors to provide appropriate solutions to the complex business challenges and initiates an effortless decision-making process.\nData Bridge Market Research\nEmail: [email protected]", "domain": "chemistry", "round": 3} +{"url": "http://www.ipltimes.com/a-quick-overlook-of-your-cheatsheet-22/", "date": "2023-12-11T21:52:31Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679518883.99/warc/CC-MAIN-20231211210408-20231212000408-00149.warc.gz", "language_score": 0.9462888836860657, "token_count": 1333, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__76461682", "lang": "en", "text": "Just How to Catch Carbon and also Transform it Into Electrical energy As international warming worsens, even more business are betting on methods to record co2 and turn it right into electricity. Click here for more info. Just How to Record Carbon and Transform it Into Electrical energy As worldwide warming worsens, more business are banking on ways to record co2 as well as transform it right into electrical power. Federal governments are adopting ambitious targets for minimizing carbon emissions, and also financiers are coming to be a lot more worried concerning the risks of environment adjustment. Nonetheless, while carbon-capture innovations have been around for decades, they are still extremely expensive and power extensive. By examining the chemical bonds in between carbon dioxide and different molecules, scientists are creating better products and techniques to catch carbon. One of these new methods is based on electrochemistry. This method predicts the toughness of a co2 bond. The researchers can after that utilize this info to determine suitable molecular candidates. As an example, they can utilize this technique to make a particle that will catch CO2. This new method might result in less costly, a lot more effective carbon capture modern technologies. Scientists have actually been developing techniques to transform heat-trapping gases right into beneficial compounds, such as electrical energy and also hydrogen. These strategies may be required widespread to keep international warming below 2.7 levels Fahrenheit as well as fend off the repercussions of climate adjustment. One of the most famous method of carbon capture is photosynthesis. Plants make use of sunlight light to fix CO2 into biomass, and many scientists are researching means to imitate the process. A comparable process takes place in aquatic atmospheres, where shellfish usage dissolved carbonate to develop solid frameworks. These frameworks are after that transferred securely in rocks around the globe. Read more here on this page to discover more about this product. Carbon capture is a required enhance to other procedures for addressing environment modification. It is a crucial public service that needs to not hinge on earnings. As carbon capture technologies come to be less expensive, much more nations will be able to adopt this modern technology and catch even more carbon. At some point, carbon capture will end up being less costly as well as a lot more prevalent, making it possible for even richer countries to record even more carbon dioxide. The modern technology can additionally record co2 from other sources, including industrial plants such as a cement manufacturing facility or an ammonia plant. Currently, the main focus of carbon capture initiatives remains in coal-fired power plants. However this can transform with the implementation of new federal government laws. While there is a little market for carbon sequestration in items, it’s unlikely to reach the range necessary to achieve its complete potential up until government plan incentivizes it. Firms are significantly considering the benefits of utilizing co2 in oilfields. Occidental, as an example, is a leader in boosted oil recovery and also uses mostly all of the carbon dioxide it extracts from oil reservoirs. By utilizing this technology to record carbon, Occidental can also benefit from tax obligation incentives and also meet corporate ecological targets. However, it will certainly likewise need to address governing problems related to emissions. In the future, Occidental is planning to use more of its recorded carbon in their oil wells. This technology can be utilized at existing and brand-new coal-fired nuclear power plant. Nevertheless, it is expensive. The process calls for large tools that can lower the efficiency of the turbine. Governments are adopting ambitious targets for minimizing carbon discharges, and also investors are coming to be extra concerned regarding the threats of environment modification. Nonetheless, while carbon-capture technologies have actually been around for decades, they are still exceptionally costly as well as power intensive. By researching the chemical bonds between carbon dioxide and different particles, scientists are creating far better products as well as techniques to capture carbon. Among these brand-new techniques is based upon electrochemistry. This method anticipates the toughness of a carbon dioxide bond. The researchers can after that utilize this info to determine suitable molecular candidates. For instance, they can utilize this method to make a particle that will certainly catch CO2. This new technique might result in less expensive, more efficient carbon capture innovations. Researchers have actually been creating techniques to transform heat-trapping gases into valuable materials, such as electrical energy and also hydrogen. These methods may be required on a large scale to keep global warming listed below 2.7 levels Fahrenheit and also repel the effects of environment change. The most famous approach of carbon capture is photosynthesis. Plants use sun light to fix CO2 right into biomass, and lots of researchers are studying methods to mimic the procedure. A comparable process occurs in aquatic atmospheres, where shellfish use liquified carbonate to develop strong structures. These structures are then deposited securely in rocks all over the globe. Carbon capture is an essential enhance to other processes for resolving climate modification. It is a crucial public service that must not be dependent on revenue. As carbon capture modern technologies come to be less expensive, a lot more nations will have the ability to embrace this modern technology and also catch even more carbon. Eventually, carbon capture will certainly come to be cheaper as well as much more extensive, making it possible for even richer nations to capture even more CO2. Read more here on this page to discover more about this product. The innovation can likewise capture carbon dioxide from other sources, consisting of industrial plants such as a cement factory or an ammonia plant. Presently, the main emphasis of carbon capture efforts is in coal-fired power plants. Click for more info on this website. But this might change with the application of brand-new government regulations. While there is a small market for carbon sequestration in products, it’s not likely to reach the range essential to achieve its full potential up until government policy incentivizes it. Companies are significantly checking out the benefits of utilizing co2 in oilfields. Occidental, as an example, is a leader in improved oil recuperation and also makes use of almost all of the co2 it draws out from oil tanks. By using this innovation to catch carbon, Occidental can also benefit from tax obligation rewards and also satisfy company ecological targets. Nevertheless, it will additionally need to attend to regulatory problems related to discharges. In the future, Occidental is preparing to make use of more of its captured carbon in their oil wells. This innovation can be utilized at existing and also new coal-fired nuclear power plant. Nevertheless, it is expensive. The procedure calls for big equipment that can reduce the efficiency of the wind turbine.\nCitation: click this link here now", "domain": "chemistry", "round": 3} +{"url": "https://www.thisisgoodmedicine.com/store/p/designs-for-health-liposomal-b-supreme/", "date": "2020-07-05T08:04:08Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-29/segments/1593655887046.62/warc/CC-MAIN-20200705055259-20200705085259-00264.warc.gz", "language_score": 0.918260931968689, "token_count": 390, "dump": "CC-MAIN-2020-29", "global_id": "webtext-fineweb__CC-MAIN-2020-29__0__222353305", "lang": "en", "text": "B vitamins are essential for energy production and for a host of biochemical reactions throughout the body that contribute to physical and mental health, as well as balanced moods and a healthy response to stress. Although B vitamins are abundant in diets based on whole, unprocessed foods that include both plant and animal foods, restrictive diets are increasing in popularity, and several lifestyle factors interfere with or impair absorption of nutrients. This means that many people may not be getting adequate levels of these crucial vitamins. Alcohol intake, chronic stress, advanced age, and commonly prescribed medications are just a few of the factors that may lead to lower levels of B vitamins in the body. And for those who have not yet transitioned to a more nutrient-rich diet, despite the fortification of processed foods with B vitamins, suboptimal levels and outright deficiencies may result from excessive alcohol consumption, chronic stress, and long-term use of several common medications. Liposomal B Supreme provides B vitamins in a highly absorbable form to ensure adequate levels of these essential nutrients for total body and mind wellness.\nWhat are Liposomes?\nLiposomes are spheres made of phospholipids—the same primary building blocks of cell membranes. Owing to this structure, liposomes bond easily with cell membranes to deliver their nutrient cargo (in this case, B vitamins). Liposomes are extremely tiny particles, which allows for fast absorption, starting in the mouth.\nWhy Liposomal B Vitamins?\nMany people have gastrointestinal complications that may impair absorption of B vitamins. Such issues include overgrowth of intestinal bacteria, inadequate stomach acid production (hypochlorhydria), malabsorptive conditions, use of medications that interfere with nutrient absorption, and more. Liposomal nutrient delivery technology bypasses these obstacles. B vitamins encased in phospholipids directly enter into circulation via the lymphatic system, thereby circumventing these common roadblocks to nutrient assimilation.", "domain": "chemistry", "round": 3} +{"url": "https://bangorrecords.com/how-to-remove-touch-up-paint/", "date": "2023-06-04T17:37:19Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-23/segments/1685224650201.19/warc/CC-MAIN-20230604161111-20230604191111-00796.warc.gz", "language_score": 0.914432942867279, "token_count": 546, "dump": "CC-MAIN-2023-23", "global_id": "webtext-fineweb__CC-MAIN-2023-23__0__17323051", "lang": "en", "text": "Removing touch up paint can be a challenge. The first step is to identify the type of paint that was used. If it is an oil-based paint, then use a solvent such as turpentine or mineral spirits to remove it. If it is a water-based paint, then use a wet cloth to remove it.\nHow To Remove Touch Up Paint\nThere are a few ways to remove touch up paint. If the paint is wet, you can use a wet cloth or sponge to wipe it away. If the paint is dry, you can use a piece of sandpaper to sand it off. You can also use a chemical stripper to remove the paint.\n-Touch up paint -Scotch tape -Paintbrush -Rag -Compressed air\n- If there is any stubborn paint left, use a bit of lacquer thinner\n- Take off any loose paint with a brush or a piece of sandpaper\n- Use a damp cloth to wipe away any remaining paint or residue\n-When painting over touch up paint, it is important to make sure that the surface is clean and free of any debris or oils. -If the touch up paint is not adhering well to the surface, it may be necessary to sand down the area before painting. -A coat of primer may also be helpful in ensuring that the new paint sticks to the surface.\nFrequently Asked Questions\nWill Nail Polish Remover Remove Touch Up Paint?\nYes, nail polish remover will remove touch up paint. It is a powerful solvent that can dissolve the paint quickly. Always be sure to test the remover on a hidden area of the surface first to make sure it does not damage the finish.\nDoes Touch Up Paint Come Off?\nTouch up paint is designed to be a temporary fix and typically does not come off. However, if the touch up paint is applied in a heavy or sloppy manner, it may chip or peel over time.\nHow Do You Remove The Wrong Color Touch Up Paint?\nTo remove the wrong color touch up paint, you can use a solvent like acetone or lacquer thinner. First, test the solvent on an inconspicuous spot to make sure it doesn’t damage the surface. Then, saturate a cloth with the solvent and rub it over the paint until it dissolves.\nRemoving touch up paint can be done in a few ways. Depending on the type of paint that is used, solvents such as lacquer thinner, acetone, or paint thinner can be used to remove the paint. Another option is to use a heat gun to soften the paint and then scrape it off.", "domain": "chemistry", "round": 3} +{"url": "http://m.nutritionraws.com/vials-lyophilized-peptides/releasing-peptides-ghrp-6-for-muscle-gain.html", "date": "2021-04-23T10:25:58Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-17/segments/1618039617701.99/warc/CC-MAIN-20210423101141-20210423131141-00591.warc.gz", "language_score": 0.875748872756958, "token_count": 681, "dump": "CC-MAIN-2021-17", "global_id": "webtext-fineweb__CC-MAIN-2021-17__0__23400342", "lang": "en", "text": "Releasing Peptides GHRP - 6 Growth Hormone Powder 5mg / vial 10mg / vial for Muscle Gain\n1407.0±65.0 °C at 760 mmHg\nGHRP-6 Functions and Traits:\nGHRP-6, and this applies to all GHRP hormones, mimic the production of ghrelin. This mode of action stimulates the ghrelin receptors, GHS-R1a or Growth Hormone Secretagogue. This stimulation acts to increase GH production by stimulating the pituitary, specifically the ghrelin receptors located in the pituitary.\nWhen the body is in a fasted state, this is when ghrelin levels are elevated. When the fasted state is met by elevated ghrelin activity, the resulting stimulation can lead to a greater production of GH in the body. However, the increase in ghrelin does not end with increases in GH. Elevated ghrelin is also known to stimulate the appetite, which may be useful for those who need excess calories to grow yet find eating difficult. Alternatively, the hormone will promote fat loss and more importantly enhance the rate of recovery. However, while ghrelin has been shown to promote recovery, in cases of GHRP-6 and elevated GH levels it is more likely that the corresponding elevated levels of IGF-1 play a larger role. IGF-1 levels will not spike at the rate comparable to direct Human Growth Hormone (HGH) use as the pulsating effect of GHRP-6 is short-lived.\n1) Reductions in body fat\n2) Increased lean mass.\n3) Increased collagen production\n4) Improved sleep\n5) Increased cellular repair\n6) An increase in IGF-1\n7) Increases in bone density\nGHRP-6 dosage and Recommendations for use:\n1) GHRP-6 should be administered on an empty stomach. No food should be consumed for 15-20 minutes post-inject, if maximum GH release is desired.\n2) When using GHRP-6 for GH release, the average dosing range is between 100-150 mcg per inject. Dosing frequency is between 1-4X per day.\n3) In order to elicit maximal elevations in GH, GHRP-6 should be combined with a GHRH, such as ModGRF1-29 (also known as CJC1295 w/o dac).\n4) If used for appetite stimulation, the common dosing range for GHRP-6 is between 100-300 per inject, as needed.\nStorage of GHRP-6:\nLyophilized GHRP-6 although stable at room temperature for 3 weeks, should be stored desiccated below -20°C.Upon reconstitution GHRP-6 should be stored at 2-8°C between 2-7 days and for future use below -20°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.\nShelf life: One year from dispatch.\nIf you are interested in this or any other series products, just feel free to contact me!", "domain": "chemistry", "round": 3} +{"url": "https://dissem.in/p/30940394/lipid-replacement-therapy-a-natural-medicine-approach-to-replacing-damaged-lipids-in-cellular-membranes-and-organelles-and-restoring-function/", "date": "2023-11-29T18:22:14Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100135.11/warc/CC-MAIN-20231129173017-20231129203017-00269.warc.gz", "language_score": 0.931147575378418, "token_count": 381, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__306230029", "lang": "en", "text": "Elsevier, BBA - Biomembranes, 6(1838), p. 1657-1679, 2014\nLipid Replacement Therapy, the use of functional oral supplements containing cell membrane phospholipids and antioxidants, has been used to replace damaged, usually oxidized, membrane glycerophospholipids that accumulate during aging and in various clinical conditions in order to restore cellular function. This approach differs from other dietary and intravenous phospholipid interventions in the composition of phospholipids and their defense against oxidation during storage, ingestion, digestion and uptake as well as the use of protective molecules that noncovalently complex with phospholipid micelles and prevent their enzymatic and bile disruption. Once the phospholipids have been taken in by transport processes, they are protected by several natural mechanisms involving lipid receptors, transport and carrier molecules and circulating cells and lipoproteins until their delivery to tissues and cells where they can again be transferred to intracellular membranes by specific and nonspecific transport systems. Once delivered to membrane sites, they naturally replace and stimulate removal of damaged membrane lipids. Various chronic clinical conditions are characterized by membrane damage, mainly oxidative but also enzymatic, resulting in loss of cellular function. This is readily apparent in mitochondrial inner membranes where oxidative damage to phospholipids like cardiolipin and other molecules results in loss of trans-membrane potential, electron transport function and generation of high-energy molecules. Recent clinical trials have shown the benefits of Lipid Replacement Therapy in restoring mitochondrial function and reducing fatigue in aged subjects and patients with a variety of clinical diagnoses that are characterized by loss of mitochondrial function and include fatigue as a major symptom. This article is part of a Special Issue entitled: Membrane structure and function: Relevance in the cell's physiology, pathology and therapy.", "domain": "chemistry", "round": 3} +{"url": "https://rd.springer.com/article/10.1023%2FA%3A1022212525438", "date": "2019-03-26T17:41:29Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-13/segments/1552912205597.84/warc/CC-MAIN-20190326160044-20190326182044-00186.warc.gz", "language_score": 0.6798113584518433, "token_count": 568, "dump": "CC-MAIN-2019-13", "global_id": "webtext-fineweb__CC-MAIN-2019-13__0__71311942", "lang": "en", "text": "Influence of Combined Treatment before Activation on the Development of Pore Structure of Anthracite\n- 25 Downloads\nThe influence of surface oxidation of anthracite with humid air, followed by impregnation with alkali metal compounds and calcination in inert atmosphere before activation, on the efficiency of steam-gas activation and on the development of the pore structure of the resulting carbon adsorbents was studied.\nKeywordsOxidation Atmosphere Calcination Pore Structure Alkali Metal\nUnable to display preview. Download preview PDF.\n- 3.Babenko, V.S., and Buyanov, R.A., Khim. Tverd. Topl., 1990, no. 4, pp. 33-38.Google Scholar\n- 4.Kucherenko, V.A., Sapunov, V.A., Zubova, T.I., et al., Khim. Tverd. Topl., 1992, no. 4, pp. 96-101.Google Scholar\n- 5.Strelko, V.V., Gerasimenko, N.V., and Kartel', N.T., Teor. Eksp. Khim., 1999, vol. 35, no. 5, pp. 306-310.Google Scholar\n- 6.Gerasimenko, N.V., Strelko, V.V., and Kartel, N.T., Abstracts of Papers, 1st World Conf. on Carbon (Eurocarbon 2000), Berlin (Germany), July 9-13, 2000, vol. 2, pp. 599-600.Google Scholar\n- 7.Strelko, V.V., Gerasimenko, N.V., and Kartel', N.T., Teor. Eksp. Khim., 2001, vol. 37, no. 1, pp. 48-52.Google Scholar\n- 8.Strelko, V.V., Kuts, V.S., and Khanasyuk, J.P., Abstracts of Papers, 23rd Biennial Conf. on Carbon (Carbon'97), Pennsylvania (the United States), July 18-23, 1997, pp. 431-432.Google Scholar\n- 9.Strelko, V.V. and Kuts, V.S., Abstracts of Papers, World Conf. on Carbon (Carbon'98), Strasbourg (France), July 5-9, 1998, pp. 773-775.Google Scholar\n- 10.Kel'tsev, N.V., Osnovy adsorbtsionnoi tekhniki (Principles of Adsorption Technology), Moscow: Khimiya, 1984.Google Scholar", "domain": "chemistry", "round": 3} +{"url": "https://www.abmole.com/literature/pbit-coa.html", "date": "2023-05-28T12:03:35Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-23/segments/1685224643784.62/warc/CC-MAIN-20230528114832-20230528144832-00207.warc.gz", "language_score": 0.8310148119926453, "token_count": 292, "dump": "CC-MAIN-2023-23", "global_id": "webtext-fineweb__CC-MAIN-2023-23__0__78765874", "lang": "en", "text": "|Solubility:||DMSO ≥ 40 mg/mL|\n|HPLC:||Shows Min 100.0% purity|\n|H-NMR:||Consistent with structure|\n|Description:||PBIT is a JARID1 (Jumonji AT-Rich Interactive Domain 1) inhibitor with IC50 values of 3, 4.9 and 6 μM for JARID1B, 1A and 1C, respectively. It can increase trimethylation of H3K4 in HeLa cells and block the proliferation of tumor cells expressing high levels of JARID1B.|\n|Stability and Solubility Advice:||Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide.\nWe recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details.", "domain": "chemistry", "round": 3} +{"url": "https://boonsgroup.uga.edu/research/chemoenzymatic-synthesis-of-complex-glycans/", "date": "2023-05-31T16:10:29Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-23/segments/1685224646937.1/warc/CC-MAIN-20230531150014-20230531180014-00011.warc.gz", "language_score": 0.8185065388679504, "token_count": 460, "dump": "CC-MAIN-2023-23", "global_id": "webtext-fineweb__CC-MAIN-2023-23__0__51249521", "lang": "en", "text": "Chemoenzymatic synthesis of complex glycans\nThe Boons group is a pioneer in the development of chemoenzymatic strategies to synthesize large collections of N– and O-glycans and human milk oligosaccharides with minimal effort for structure-activity relationship studies. These methods make use of strategically selected substrates that can be diversified in a controlled manner by glycosyl transferase catalyzed transformations. In addition, an automation platform has been introduced for enzyme mediated oligosaccharide synthesis to further speed up the process of glycan assembly. These efforts have resulted in a large collection of compounds that have been used for glycan array development. Screening studies have provided new insights into the molecular mechanisms of carbohydrate-protein binding; particularly, we have shown that glycan recognition is modulated by the presentation of minimal epitopes in the context of complex glycans.\nLi T, Liu L, Wei N, Yang JY, Chapla DG, Moremen KW, Boons GJ (2019) An automated platform for the enzyme-mediated assembly of complex oligosaccharides. Nat Chem 11(3):229-236.\nLiu L, Prudden AR, Capicciotti CJ, Bosman GP, Yang JY, Chapla DG, Moremen KW, Boons GJ (2019) Streamlining the chemoenzymatic synthesis of complex N-glycans by a stop and go strategy. Nat Chem 11(2):161-169.\nPrudden AR, Liu L, Capicciotti CJ, Wolfert MA, Wang S, Gao Z, Meng L, Moremen KW, Boons GJ (2017) Synthesis of asymmetrical multiantennary human milk oligosaccharides. Proc Natl Acad Sci USA 114(27):6954-6959.\nWang Z, Chinoy Z, Ambre S, Peng W, McBride R, de Vries RP, Glushka J, Paulson JC, Boons GJ (2013) A general strategy for the chemoenzymatic synthesis of asymmetrically branched N-glycans. Science 341(6144):379-383.", "domain": "chemistry", "round": 3} +{"url": "https://www.hindawi.com/journals/isrn/2012/601458/ref/", "date": "2017-02-26T02:03:02Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-09/segments/1487501171932.64/warc/CC-MAIN-20170219104611-00484-ip-10-171-10-108.ec2.internal.warc.gz", "language_score": 0.691239058971405, "token_count": 1689, "dump": "CC-MAIN-2017-09", "global_id": "webtext-fineweb__CC-MAIN-2017-09__0__63724150", "lang": "en", "text": "- About this Journal ·\n- Abstracting and Indexing ·\n- Aims and Scope ·\n- Article Processing Charges ·\n- Articles in Press ·\n- Author Guidelines ·\n- Bibliographic Information ·\n- Citations to this Journal ·\n- Contact Information ·\n- Editorial Board ·\n- Editorial Workflow ·\n- Free eTOC Alerts ·\n- Publication Ethics ·\n- Reviewers Acknowledgment ·\n- Submit a Manuscript ·\n- Subscription Information ·\n- Table of Contents\nISRN Chemical Engineering\nVolume 2012 (2012), Article ID 601458, 5 pages\nDetermination of Oxygen Solubility in Liquid Media\n1Chemical and Food Engineering Department, Federal University of Santa Catarina (UFSC), P.O. Box 476, 88040-900 Florianópolis, SC, Brazil\n2Microbiology, Immunology and Parasitology Department, Federal University of Santa Catarina (UFSC), P.O. Box 476, 88040-900 Florianópolis, SC, Brazil\nReceived 23 February 2012; Accepted 26 April 2012\nAcademic Editors: G. Bayramoglu and A. Brucato\nCopyright © 2012 Francielo Vendruscolo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.\n- W. Schmidell, “Transferência de oxigênio em biorreatores,” in Biotecnologia Industrial, W. Schmidell, W. Borzani, U. A. Lima, and E. Aquarone, Eds., vol. 2, pp. 380–410, Edgard Blücher, São Paulo, Brazil, 2001.\n- O. Käppeli and A. Fiechter, “A convenient method for the determination of oxygen solubility in different solutions,” Biotechnology and Bioengineering, vol. 23, pp. 1897–1901, 1981.\n- L. W. Winkler, “Die Bestimmung des im Wasser gelösten Sauerstoffes,” Berichte der Deutschen Chemischen Gesellschaft, vol. 21, pp. 2843–2855, 1888.\n- P. Doran, Bioprocess Engineering Principles, Elsevier Science & Technology Books, Australia, 1995.\n- H. W. Blanch and D. S. Clark, Biochemical Engineering, New York, NY, USA, 1997.\n- F. Vendruscolo, L. O. Pitol, B. A. M. Carciofi et al., “Construction and application a vane system in a rotational rheometer for determination of the rheological properties of Monascus ruber CCT 3802,” Journal of Biorheology, pp. 1–7, 2010.\n- A. Gupta and G. Rao, “A study of oxygen transfer in shake flasks using a non-invasive oxygen sensor,” Biotechnology and Bioengineering, vol. 84, no. 3, pp. 351–358, 2003.\n- J. Pérez, J. L. Montesinos, and F. Gòdia, “Gas-liquid mass transfer in an up-flow cocurrent packed-bed biofilm reactor,” Biochemical Engineering Journal, vol. 31, no. 3, pp. 188–196, 2006.\n- F. Garcia-Ochoa and E. Gomez, “Bioreactor scale-up and oxygen transfer rate in microbial processes: an overview,” Biotechnology Advances, vol. 27, no. 2, pp. 153–176, 2009.\n- G. J. Clark, D. Langley, and M. E. Bushell, “Oxygen limitation can induce microbial secondary metabolite formation: investigations with miniature electrodes in shaker and bioreactor culture,” Microbiology, vol. 141, no. 3, pp. 663–669, 1995.\n- W. Katzer, M. Blackburn, K. Charman, S. Martin, J. Penn, and S. Wrigley, “Scale-up of filamentous organisms from tubes and shake-flasks into stirred vessels,” Biochemical Engineering Journal, vol. 7, no. 2, pp. 127–134, 2001.\n- J. B. Gros, C. G. Dussap, and M. Catté, “Estimation of O2 and CO2 solubility in microbial culture media,” Biotechnology Progress, vol. 15, no. 5, pp. 923–927, 1999.\n- Y. Shi, D. D. Y. Ryu, and S. H. Park, “Performance of mammalian cell culture bioreactor with a new impeller design,” Biotechnology and Bioengineering, vol. 40, no. 2, pp. 260–270, 1992.\n- E. Gnaiger, “Oxygen calibration and solubility in experimental media,” Mitochondrial Physiology Network, vol. 6, pp. 1–12, 2010.\n- R. M. Meinicke, F. Vendruscolo, D. E. Moritz, et al., “Potential use of glycerol as substrate for the production of red pigments by Monascus ruber in submerged fermentation,” Biocatalysis and Agricultural Biotechnology, vol. 1, pp. 238–242, 2012.\n- G. L. Miller, “Use of dinitrosalicylic acid reagent for determination of reducing sugar,” Analytical Chemistry, vol. 31, no. 3, pp. 426–428, 1959.\n- H. Hajjaj, A. Klaébé, M. O. Loret, T. Tzédakis, G. Goma, and P. J. Blanc, “Production and identification of N-glucosylrubropunctamine and N-glucosylmonascorubramine from Monascus ruber and occurrence of electron donor-acceptor complexes in these red pigments,” Applied and Environmental Microbiology, vol. 63, no. 7, pp. 2671–2678, 1997.\n- M. J. Rossi, Tecnologia para produção de inoculantes de fungos ectomicorrízicos utilizando cultivo submerso em biorreator airlift [Tese de Doutorado], Universidade Federal de Santa Catarina, Florianópolis, Brazil, 2006.\n- H. J. Henzler and D. J. Kauling, “Oxygenation of cell cultures,” Bioprocess Engineering, vol. 9, no. 2-3, pp. 61–75, 1993.\n- Kothandaraman, “Effects of contaminants on reaeration rates in river water,” Journal of the Water Pollution Control Federation, vol. 43, no. 5, pp. 806–817, 1971.\n- P. J. Slininger, R. J. Petroski, J. Bothast, M. R. Ladisch, and M. R. Okos, “Measurement of oxygen solubility in fermentation media: a colorimetric method,” Biotechnology and Bioengineering, vol. 33, pp. 578–583, 1989.\n- M. Popovic, H. Niebelschiitz, and M. Reub, “Oxygen solubilities in fermentation fluids,” European Journal of Applied Microbiology and Biotechnology, vol. 8, no. 1, 1979.", "domain": "chemistry", "round": 3} +{"url": "http://www.apexbt.com/pf-562271.html", "date": "2017-05-01T02:20:31Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-17/segments/1492917126538.54/warc/CC-MAIN-20170423031206-00086-ip-10-145-167-34.ec2.internal.warc.gz", "language_score": 0.6602946519851685, "token_count": 636, "dump": "CC-MAIN-2017-17", "global_id": "webtext-fineweb__CC-MAIN-2017-17__0__219145841", "lang": "en", "text": "|PF-562271ATP-competitive FAK inhibitor, reversible|\nSample solution is provided at 25 µL, 10mM.\nPublications citing ApexBio Products\nRelated Compound Libraries\n|Description||PF-562271 is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, except for some CDKs.|\n|IC50||1.5 nM||14 nM|\n|Cas No.||717907-75-0||SDF||Download SDF|\n|Solubility||>25.4mg/mL in DMSO||Storage||Store at -20°C|\nPF-562271 is a potent, ATP-competitive and reversible inhibitor of both focal adhesion kinase (FAK), a non-receptor tyrosine kinase involved in a variety of cellular events, and proline-rich tyrosine kinase 2 (Pyk2), an FAK homolog containing 48% amino acid identity, with half maximal inhibitory concentration (IC50) of 1.5 nmol/L and 14 nmol/L respectively. As a potential therapeutic agent either alone or in combination with other agents for the treatment of cancer, PF-562271 has been reported to effectively inhibit the proliferation of tumors in both xenograft and transgenic mouse models, in which it dose-dependently inhibits FAK phosphorylation in tumor-bearing mice with half maximal effective concentration (EC50) of 93 ng/mL.\nStokes JB, Adair SJ, Slack-Davis JK, Walters DM, Tilghman RW, Hershey ED, Lowrey B, Thomas KS, Bouton AH, Hwang RF, Stelow EB, Parsons JT, Bauer TW. Inhibition of focal adhesion kinase by PF-562,271 inhibits the growth and metastasis of pancreatic cancer concomitant with altering the tumor microenvironment. Mol Cancer Ther. 2011 Nov;10(11):2135-45. doi: 10.1158/1535-7163.MCT-11-0261. Epub 2011 Sep 8.\nRoberts WG, Ung E, Whalen P, Cooper B, Hulford C, Autry C, Richter D, Emerson E, Lin J, Kath J, Coleman K, Yao L, Martinez-Alsina L, Lorenzen M, Berliner M, Luzzio M, Patel N, Schmitt E, LaGreca S, Jani J, Wessel M, Marr E, Griffor M, Vajdos F. Antitumor activity and pharmacology of a selective focal adhesion kinase inhibitor, PF-562,271. Cancer Res. 2008 Mar 15;68(6):1935-44. doi: 10.1158/0008-5472.CAN-07-5155.", "domain": "chemistry", "round": 3} +{"url": "http://iccc2014.org/%EF%BB%BFhowever-cxcr4-inhibitors-ideal-for-long-term-use-as-necessary-for-anticancer-therapy-arent-obtainable/", "date": "2022-10-04T00:11:27Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-40/segments/1664030337446.8/warc/CC-MAIN-20221003231906-20221004021906-00046.warc.gz", "language_score": 0.9070911407470703, "token_count": 1260, "dump": "CC-MAIN-2022-40", "global_id": "webtext-fineweb__CC-MAIN-2022-40__0__5173373", "lang": "en", "text": "However CXCR4 inhibitors ideal for long term use as necessary for anticancer therapy aren’t obtainable. M) or AMD3100(10 M) and incubated with anti CXCR3 antibody; D. Baseline calcium mineral efflux was founded, then chemokines had been added as indicated and chemokine induced calcium mineral efflux was assessed. CCRF-CEM cells had been preincubated for thirty minutes with CXCL12 (100 nM), Peptide T (10 M) or AMD3100 (10 M) or iomycin as positive control. Fluo-3AM and Pluronic acidity had been put into each sample to improve Fluo-3AM solubility and improve dye launching in to the cells.(TIF) IMP4 antibody pone.0074548.s003.tif (1.2M) GUID:?56D41B7F-673F-48C8-AB08-3EC0C8D19A12 Shape S4: Peptide R inhibited CCRF-CEM human being T-Leukemia cells migration inside a dose-dependent manner. (TIF) pone.0074548.s004.tif (345K) GUID:?CB91774B-61C1-407E-89D0-7F7EF5620E50 Figure S5: Peptide R inhibits S107 the CXCL12 induced p-ERK. PES43 cell lines had been serum starved for 16 hours. Then your cells had been preincubated for thirty minutes with Peptide R (10 M) or AMD3100 (10 M) and treated with CXCL12 (100 nM).(TIF) pone.0074548.s005.tif (362K) GUID:?140FD384-B886-4D28-88D8-C799EF193D9C Abstract a job is definitely played from the CXCR4/CXCL12 axis in cancer metastases, S107 stem cell chemosensitization and mobilization. Proof of idea for effective CXCR4 inhibition continues to be proven in stem cell mobilization ahead of autologous transplantation in hematological malignancies. However CXCR4 inhibitors ideal for long term use as necessary for anticancer therapy aren’t available. To build up fresh CXCR4 antagonists a logical, ligand-based strategy was taken, distinct through the more used advancement strategy commonly. A three amino acidity theme (Ar-Ar-X) in CXCL12, also within the invert orientation (X-Ar-Ar) in the vMIP-II inhibitory chemokine produced the primary of nineteen cyclic peptides examined for S107 inhibition of CXCR4-reliant migration, binding, Calcium and P-ERK1/2-induction efflux. Peptides R, S and I had been selected for evaluation in types of lung metastases (B16-CXCR4 and KTM2 murine osteosarcoma cells) and development of the renal cells xenograft. Peptides R, S, and T considerably decreased the association from the 12G5-CXCR4 antibody towards the receptor and inhibited CXCL12-induced calcium mineral efflux. The four peptides effectively inhibited CXCL12-reliant migration at concentrations only 10 nM and postponed CXCL12-mediated wound curing in PES43 individual melanoma cells. Intraperitoneal treatment with peptides R, I or S reduced the amount of B16-CXCR4-derived lung metastases in C57/BL mice drastically. KTM2 osteosarcoma lung metastases were low in Balb/C mice following CXCR4 inhibition also. All three peptides inhibited subcutaneous development of SN12C-EGFP renal cancers cells significantly. A novel course of CXCR4 inhibitory peptides was uncovered. Three peptides, R, I and S inhibited lung metastases and principal tumor development and you will be examined as anticancer realtors. Introduction Chemokines certainly are a huge category of 8 to 12 kDa peptides that serve as chemoattractants for mobile activation, trafficking and differentiation. To time, about 50 chemokines have already been identified in human beings, and these have already been grouped into four households – CXC, CC, CX3C, and XC – predicated on the agreement of cysteine residues mixed up in development of disulfide bonds C. The natural actions of chemokines are exerted via seven transmembrane domains G-protein combined chemokine receptors having lengthy disordered N and C-terminal locations and three extracellular loops and three intracellular loops. The chemokine CXCL12 (stromal cell-derived aspect-1) binds towards the CXCR4 and CXCR7 receptors, initiating divergent signaling pathways that bring about chemotaxis, cell success and/or proliferation, elevated intracellular transcription and calcium mineral of genes crucial for cell irritation and cancers metastases , . CXCR4 receptor activation is normally mediated by coupling for an intracellular heterotrimeric G-protein from the internal surface from the plasma membrane , . Though it was initially believed that CXCR4 just transduces via an intracellular heterotrimeric G-protein subunit Gi , latest proof suggests CXCR4 consists of Gq, Go, and Gs and activates different downstream pathways thus. A discovered receptor newly, CXCR7, binds CXCL12 with higher affinity than CXCR4 , and regulates CXCR4 function . While.\nHowever CXCR4 inhibitors ideal for long term use as necessary for anticancer therapy aren’t obtainable", "domain": "chemistry", "round": 3} +{"url": "http://gazetadailys.tk/neosynephrine-msds-sheet.html", "date": "2019-06-18T15:53:38Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-26/segments/1560627998755.95/warc/CC-MAIN-20190618143417-20190618165417-00393.warc.gz", "language_score": 0.7287201881408691, "token_count": 919, "dump": "CC-MAIN-2019-26", "global_id": "webtext-fineweb__CC-MAIN-2019-26__0__161820409", "lang": "en", "text": "Phenylephrine or sheet Neo- Synephrine is an α1- adrenergic receptor agonist used primarily. HAZARDOUS MATERIALS/ SDS. the hazard criteria of the Controlled Products Regulations and the MSDS contains. , sinusitis, bronchitis). SAFETY DATA SHEET Product Name: AQUAGEL® LUBRICATING GEL sheet US Department of Labor Occupational Safety Health Administration SDS- 57- 1 Page 1 of 4 SECTION 1 — CHEMICAL PRODUCT COMPANY IDENTIFICATION. Precedex ( dexmedetomidine hydrochloride) in 0.\nMATERIAL SAFETY DATA SHEET Product Name: NEO- SYNEPHRINE® HYDROCHLORIDE ( phenylephrine hydrochloride injection) 1. Product sizes may vary slightly based on production tolerances using the metric system and are stated neosynephrine for marketing msds purposes only. INVENTORY Click on Link to View SDS for Product. ” An invitation to GBA readers. Precedex ( dexmedetomidine hydrochloride) injection is a sterile, nonpyrogenic solution suitable for intravenous infusion following dilution. MATERIAL SAFETY DATA SHEET GENERAL INFORMATION PRODUCT NAME msds sheet City, NUMBER ( as it appears on label) Aqua- Gel® II Utility Cable Pulling Lubricant MANUFACTURER’ S NAME ADDRESS ( Number, Zip Code) Becker Place, Sycamore, State, Street, IL 60178 CATALOG neosynephrine NUMBER All “ msds 31” Series neosynephrine EMERGENCY T IDEAL INDUSTRIES INC. Hydralazine ( Apresoline) is an antihypertensive medication sheet used to treat high blood pressure. 275 North Field Drive neosynephrine Lake Forest, Illinois USA 60045 Emergency Telephone CHEMTREC: North America: ;. Have you sheet worked with clients with multiple chemical sensitivity? LEVOPHED prescription dosage sheet msds sizes information for physicians healthcare professionals. It sheet is a peripheral arterial vasodilator towards the organs msds , causes relaxation of blood vessels which neosynephrine carry blood away from the heart tissues.\nPhenylephrine is msds used for the temporary relief of stuffy nose allergies, , sinus, flu, , ear symptoms caused by the common cold other breathing illnesses ( e. Neosynephrine Synthesis Reference Synthesis from m- benzyloxybenzaldehyde: Bergmann Sulzbacher J. Much better than trying neosynephrine to get sheet anything neosynephrine useful from a MSDS sheet. Neosynephrine msds sheet. If they don’ t bother the client, they go in the building. pdf X X 409 All Purpose Cleaner 409AllPurposeMSDS. The information provided in this Safety Data Sheet is correct to the best of our knowledge information belief at the date of msds its publication.\nNeosynephrine msds neosynephrine ( material safety sheet) Neosynephrine MSDS. msds Material Safety Data Sheet L( - ) - Phenylephrine Hydrochloride, 99%. MATERIAL SAFETY DATA SHEET FOUNDATION CONSUMER HEALTHCARE 1190 Omega Drive. CHEMICAL neosynephrine PRODUCT msds COMPANY INFORMATION Manufacturer Name Address Hospira Inc. not a replacement for a full Material Safety Data Sheet ( MSDS).\nMedscape - Indication- specific dosing for Levarterenol, Levophed ( norepinephrine), frequency- based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information. MSDS Page 1 Continued on next page. ROUTE( s) OF HAZARDS ( continued) Appropriate tout e : nasal spray. this sheet relates only to the designated herein. MATERIAL SAFETY DATA SHEET Product Name: METOCLOPRAMIDE Metoclopramide Hydrochloride Injection 1.\nneosynephrine msds sheet\nCHEMICAL PRODUCT AND COMPANY INFORMATION Manufacturer Name And. 15 ml ophthalmic solution Refrigeration required, additional shipping costs will apply. Compare to: Neo- Synephrine ® / Mydfrin ® / AK- Dilate ® Download MSDS Sheet.", "domain": "chemistry", "round": 3} +{"url": "https://www.thermofisher.com/us/en/home/references/ambion-tech-support/rna-isolation/tech-notes/melt-total-nucleic-acid-isolation-system-hands-free-tissue-disruption.html", "date": "2021-10-24T13:59:42Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-43/segments/1634323585997.77/warc/CC-MAIN-20211024111905-20211024141905-00410.warc.gz", "language_score": 0.8926254510879517, "token_count": 1115, "dump": "CC-MAIN-2021-43", "global_id": "webtext-fineweb__CC-MAIN-2021-43__0__272614678", "lang": "en", "text": "- Hands-free tissue disruption in minutes: no grinding or polytron required\n- Suitable for RT-PCR, PCR, and microarray gene expression analysis\n- Isolate both total RNA and genomic DNA\n- Protect and preserve RNA for days in tissue lysates at ambient temperature\nA Better Way to Disrupt Tissue and Isolate RNA and DNA\nAmbion’s Multi-Enzymatic Liquefaction of Tissue (MELT™) Total Nucleic Acid Isolation System (patent pending) is a simpler and safer alternative to traditional RNA and genomic DNA isolation procedures. The MELT System permits the hands-free disruption of several solid tissues in parallel without the need of tissue grinding or a polytron, which can create toxic aerosols. Samples can be lysed easily in a closed-tube format without cross-contamination. Up to 10 mg of fresh or frozen tissue can be liquefied at room temperature in 5–15 minutes using a combination of powerful catabolic enzymes and a potent small-molecule RNase inhibitor. Following digestion, the RNA or DNA is purified using a streamlined process based on Ambion’s MagMAX™ magnetic bead technology (patent pending). The purified RNA or DNA can be eluted from the beads in a concentrated form in as little as 15–20 µl.\nA Variety of Tissues can be Processed in the MELT System\nThe MELT System is compatible with a range of freshly procured or flash-frozen tissues. There is no lower limit of tissue mass for processing, and tissues up to 10 mg in size are suitable for digestion. More than a dozen commonly studied human and rodent tissues, and cultured cells have been used successfully with the MELT system (Figure 1).\nFigure 1. Tissues and Cultured Cells Compatible with the MELT™ System.\nHigh Quality MELT RNA is Suitable for Many Applications\nThe goal of any RNA isolation procedure is to recover an RNA population that is highly representative of the biological sample at the time of procurement. Ambion extensively validated the MELT technology to ensure that the purified RNA was functionally equivalent to traditionally isolated RNA. The resulting RNA was tested by endpoint RT-PCR to amplify products as long as 8 kb and real-time RT-PCR to quantify the expression level of nearly a dozen different sentinel transcripts . In addition, microarray analyses that have interrogated >14,000 genes revealed the MELT system to be highly correlated with the RNA isolation method recommended in the Affymetrix® GeneChip® Expression Analysis Technical Manual .\nConveniently Store Lysates for Future Use\nA major threat to RNA stability in tissues is RNase activity . Unlike harsh chaotropes such as guanidine, the MELT reagents digest tissue to the molecular level, preventing reactivation of problematic RNases. Once the tissue digestion is complete, the MELT lysate can be stored frozen at -20°C, -80°C, or even at room temperature (for up to a week for many tissues) without a significant loss in RNA stability . Lysates can be stored similarly for DNA isolation.\nIsolate Both RNA and DNA\nThe MELT system is now available with the option to isolate genomic DNA from solid tissues, including mouse tails. Although conventional mouse tail DNA isolation procedures require lengthy, overnight digestions, MELT provides both tissue digestion and DNA isolation protocols that can be completed in just hours, enabling same day results. DNA can be purified from MELT lysates (Figure 2) with reagents provided in the current kit format, along with RNase A (not included) for an optional RNase treatment step. The purified DNA is suitable for both endpoint and real-time PCR.\nFigure 2. DNA Isolation Using the MELT™ Total Nucleic Acid Isolation System. (A) 1% Agarose gel, ethidium bromide stained, displays DNA isolated from various tissue types with the MELT System (~500 ng of each sample per lane). (B) Real-time PCR targeting GAPDH and FAS genomic sequences using 100 ng input RNA and TaqMan® technology (ABI). Error bars indicate the range from duplicate reactions.\nMELT Total Nucleic Acid Isolation System\nEach kit contains sufficient reagents to process 50 tissue samples (<10 mg each) for either RNA or genomic DNA isolation. A specially designed vortex adapter and either 6 tube or 96 well magnetic stands are available separately for multi-sample processing. The ability of the MELT system to achieve both tissue digestion and RNA preservation enables samples to be safely processed, conveniently stored, and readily transported at ambient temperatures for a host of downstream analyses.\n- Peltier H, Latham G (2005) Watch your tissue MELT into high quality total RNA. Ambion TechNotes 12(3):27.\n- Latham G, Peltier H (2005) MELT™ Total Nucleic Acid Isolation System: a new technology for hands-free tissue disruption, RNA preservation and total nucleic acid purification. Nature Methods 2(9):i–iii.\n- Krosting J, Latham G (2005) RNase activity in mouse tissues: classification, hierarchy, and methods for control. Ambion TechNotes 12(3):28.", "domain": "chemistry", "round": 3} +{"url": "https://www.nist.gov/publications/chapter-6-characterization-nanofiber-devices", "date": "2020-04-04T02:54:33Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-16/segments/1585370519111.47/warc/CC-MAIN-20200404011558-20200404041558-00249.warc.gz", "language_score": 0.9344193935394287, "token_count": 264, "dump": "CC-MAIN-2020-16", "global_id": "webtext-fineweb__CC-MAIN-2020-16__0__21257309", "lang": "en", "text": "Previous chapters have introduced and described a variety of measurement techniques for RF nanoelectronic devices. Here, our objective is to work through an illustrative example that highlights strategies and challenges related to implementing a specific RF nanoelectronic device measurement. To that end, this chapter will describe the broadband, two-port characterization of an individual nanofiber device (Here, a nanofiber is broadly defined to be any individual nanotube or nanowire, or a bundle of nanotubes or nanofiber). Historically, the electromagnetic characterization of individual carbon nanotubes at gigahertz frequencies was one of the first measurement challenges encountered in the relatively short history of RF nanoelectronics -. Interest in making accurate RF measurements of nanotubes has been driven largely by the potential uses of carbon nanotubes as high-quality interconnects in very large scale integrated circuits and as nano-antennas in communications applications . In addition, such measurements were needed to investigate what influence, if any, the quantum capacitance and kinetic inductance have on the AC transport properties of carbon nanotubes . The techniques that were developed for electromagnetic characterization of carbon nanotubes have subsequently been applied to additional nano-material systems, including semiconducting nanowires and graphene nanoribbons -.", "domain": "chemistry", "round": 3} +{"url": "https://www.ornl.gov/news?f%5B0%5D=all_news_news_type%3ANewsReleases&f%5B1%5D=all_news_science_area%3A945&f%5B2%5D=related_news_topics%3A1159&f%5B3%5D=related_news_topics%3A1173&f%5B4%5D=related_news_topics%3A1183&f%5B5%5D=related_news_topics%3A1199&f%5B6%5D=related_news_topics%3A1202&f%5B7%5D=related_news_topics%3A1220", "date": "2020-07-13T12:18:26Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-29/segments/1593657143365.88/warc/CC-MAIN-20200713100145-20200713130145-00183.warc.gz", "language_score": 0.9140978455543518, "token_count": 384, "dump": "CC-MAIN-2020-29", "global_id": "webtext-fineweb__CC-MAIN-2020-29__0__233747198", "lang": "en", "text": "Scientists at ORNL used neutron scattering and supercomputing to better understand how an organic solvent and water work together to break down plant biomass, creating a pathway to significantly improve the production of renewable biofuels and bioproducts.\nFor the second year in a row, a team from the Department of Energy’s Oak Ridge and Los Alamos national laboratories led a demonstration hosted by EPB, a community-based utility and telecommunications company serving Chattanooga, Tennessee.\nAn international team of researchers has discovered the hydrogen atoms in a metal hydride material are much more tightly spaced than had been predicted for decades — a feature that could possibly facilitate superconductivity at or near room temperature and pressure.\nThe U.S. Department of Energy’s Office of Science announced allocations of supercomputer access to 47 science projects for 2020.\nProcesses like manufacturing aircraft parts, analyzing data from doctors’ notes and identifying national security threats may seem unrelated, but at the U.S. Department of Energy’s Oak Ridge National Laboratory, artificial intelligence is improving all of these tasks.\nOAK RIDGE, Tenn., March 11, 2019—An international collaboration including scientists at the Department of Energy’s Oak Ridge National Laboratory solved a 50-year-old puzzle that explains why beta decays of atomic nuclei\nOAK RIDGE, Tenn., Feb. 12, 2019—A team of researchers from the Department of Energy’s Oak Ridge and Los Alamos National Laboratories has partnered with EPB, a Chattanooga utility and telecommunications company, to demonstrate the effectiveness of metro-scale quantum key distribution (QKD).\nThe US Department of Energy’s Oak Ridge National Laboratory is once again officially home to the fastest supercomputer in the world, according to the TOP500 List, a semiannual ranking of the world’s fastest computing systems.", "domain": "chemistry", "round": 3} +{"url": "https://research.pasteur.fr/en/publication/full-length-archaeal-rad51-structure-and-mutants-mechanisms-for-rad51-assembly-and-control-by-brca2/", "date": "2023-06-07T13:13:08Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-23/segments/1685224653764.55/warc/CC-MAIN-20230607111017-20230607141017-00270.warc.gz", "language_score": 0.7990676164627075, "token_count": 318, "dump": "CC-MAIN-2023-23", "global_id": "webtext-fineweb__CC-MAIN-2023-23__0__140183602", "lang": "en", "text": "Link to Pubmed [PMID] – 12941707\nEMBO J 2003 Sep; 22(17): 4566-76\nTo clarify RAD51 interactions controlling homologous recombination, we report here the crystal structure of the full-length RAD51 homolog from Pyrococcus furiosus. The structure reveals how RAD51 proteins assemble into inactive heptameric rings and active DNA-bound filaments matching three-dimensional electron microscopy reconstructions. A polymerization motif (RAD51-PM) tethers individual subunits together to form assemblies. Subunit interactions support an allosteric ‘switch’ promoting ATPase activity and DNA binding roles for the N-terminal domain helix-hairpin-helix (HhH) motif. Structural and mutational results characterize RAD51 interactions with the breast cancer susceptibility protein BRCA2 in higher eukaryotes. A designed P.furiosus RAD51 mutant binds BRC repeats and forms BRCA2-dependent nuclear foci in human cells in response to gamma-irradiation-induced DNA damage, similar to human RAD51. These results show that BRCA2 repeats mimic the RAD51-PM and imply analogous RAD51 interactions with RAD52 and RAD54. Both BRCA2 and RAD54 may act as antagonists and chaperones for RAD51 filament assembly by coupling RAD51 interface exchanges with DNA binding. Together, these structural and mutational results support an interface exchange hypothesis for coordinated protein interactions in homologous recombination.", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/icad-antibody-ab227307.html", "date": "2020-10-23T08:04:48Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-45/segments/1603107880878.30/warc/CC-MAIN-20201023073305-20201023103305-00391.warc.gz", "language_score": 0.7179391384124756, "token_count": 473, "dump": "CC-MAIN-2020-45", "global_id": "webtext-fineweb__CC-MAIN-2020-45__0__139381213", "lang": "en", "text": "Key features and details\n- Rabbit polyclonal to ICAD\n- Suitable for: WB\n- Reacts with: Human\n- Isotype: IgG\nProduct nameAnti-ICAD antibody\nSee all ICAD primary antibodies\nDescriptionRabbit polyclonal to ICAD\nTested applicationsSuitable for: WBmore details\nSpecies reactivityReacts with: Human\nPredicted to work with: Rhesus monkey\nRecombinant fragment within Human ICAD (internal sequence). The exact sequence is proprietary.\nDatabase link: O00273\n- WB: HEK-293T whole cell lysate.\nStorage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.\nStorage bufferpH: 7.00\nPreservative: 0.01% Thimerosal (merthiolate)\nConstituents: 1.21% Tris, 0.75% Glycine, 10% Glycerol (glycerin, glycerine)\nConcentration information loading...\nPurityImmunogen affinity purified\nOur Abpromise guarantee covers the use of ab227307 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\n|WB||1/500 - 1/3000. Predicted molecular weight: 37 kDa.|\nFunctionInhibitor of the caspase-activated DNase (DFF40).\nSequence similaritiesContains 1 CIDE-N domain.\nmodificationsCaspase-3 cleaves DFF45 at 2 sites to generate an active factor.\nPhosphorylated upon DNA damage, probably by ATM or ATR.\n- Information by UniProt\n- A330085O09Rik antibody\n- Caspase activated deoxyribonuclease inhibitor short form antibody\n- DFF 1 antibody\nTo our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.\nab227307 has not yet been referenced specifically in any publications.", "domain": "chemistry", "round": 3} +{"url": "https://businessrecycling.com.au/recycle/chemical-drums?", "date": "2022-08-18T16:57:22Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882573242.55/warc/CC-MAIN-20220818154820-20220818184820-00209.warc.gz", "language_score": 0.9236559867858887, "token_count": 381, "dump": "CC-MAIN-2022-33", "global_id": "webtext-fineweb__CC-MAIN-2022-33__0__126790732", "lang": "en", "text": "Recycling or reconditioning chemical drums eliminates these large items form the waste stream and removes them from sites where they may cause contamination or safety issues.\nFind a recycler\nChemical drums are made from recyclable materials, primarily plastics and steel. By recycling or reconditioning chemical drums this diverts a stream of large waste items form landfill and preserves the natural resources needed to produce drums from virgin materials. By utilising a recycling service this also removes potentially hazardous waste, helping to avoid contamination and improving safety.\ndrumMUSTER is the National program that has been set up for the collection and recycling of cleaned eligible non returnable crop production and on-farm animal health chemical containers.This is a free, drop off service and containers must carry the drumMUSTER logo to be eligible. The program will not accept petroleum or liquid chlorine containers that are used for non-agricultural purposes\nIn addition to this program a number of commercial operators will purchase or accept chemical drums for recycling, reconditioning for resale. This may be through a pick-up or drop off service.\nWhat Happens When It’s Recycled?\nReconditioning: Drums are collected, cleaned and where needed reconditioned, such as the replacement of closures and lids. These drums are then resold.\nRecycling: Drums must be triple-rinsed and punctured before they can be accepted for crushing. Once crushed the metal drums are transported to Melbourne for recycling. Reusable plastic drums will be returned to the relevant chemical company. Non-reusable drums will be shredded and recycled for uses such as plastic culvert pipes.\nMore Info & Sources\ndrumMuster online or call 1800 008 707", "domain": "chemistry", "round": 3} +{"url": "https://repository.kaust.edu.sa/handle/10754/595312", "date": "2023-03-25T17:19:43Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-14/segments/1679296945368.6/warc/CC-MAIN-20230325161021-20230325191021-00443.warc.gz", "language_score": 0.6711201667785645, "token_count": 381, "dump": "CC-MAIN-2023-14", "global_id": "webtext-fineweb__CC-MAIN-2023-14__0__111226677", "lang": "en", "text": "Patent StatusGranted Patent\nKAUST DepartmentElectrical Engineering Program\nPermanent link to this recordhttp://hdl.handle.net/10754/595312\nMetadataShow full item record\nAbstractA method for making a mechanically flexible silicon substrate is disclosed. In one embodiment, the method includes providing a silicon substrate. The method further includes forming a first etch stop layer in the silicon substrate and forming a second etch stop layer in the silicon substrate. The method also includes forming one or more trenches over the first etch stop layer and the second etch stop layer. The method further includes removing the silicon substrate between the first etch stop layer and the second etch stop layer.\nApplication NumberUS 20140239459 A1", "domain": "chemistry", "round": 3} +{"url": "http://www.burwellnebout.com/blog/2015/01/dupont-may-have-been-exposing-workers-to-lethal-chemicals-for-years.shtml", "date": "2017-05-23T10:49:48Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-22/segments/1495463607620.78/warc/CC-MAIN-20170523103136-20170523123136-00020.warc.gz", "language_score": 0.9811393022537231, "token_count": 739, "dump": "CC-MAIN-2017-22", "global_id": "webtext-fineweb__CC-MAIN-2017-22__0__38713841", "lang": "en", "text": "Government agencies regulate the industry, but a Houston chemical plant accident can still occur. Executives with chemical plants may follow the agencies' rules and regulations, but a Houston wrongful death in an industrial accident can happen. This may mean that there is negligence on the part of the government agency, the chemical plant or both. It also means that those affected need to hire a Houston industrial accident attorney to file a claim against those responsible for the accident. An Example of One Company's Failure DuPont's chemical plant in La Porte, Texas experienced a leak on November 15, 2014. As a result of this chemical leak, four plant employees lost their lives. On that day at 4 a.m., the plant began to leak methyl mercaptan into the air, and it took rescue workers two hours to contain the leak. Although people could smell the chemical in the air as far away as Sugar Land, the air was not deemed to be dangerous to humans. Previous Leaks The November 15th incident is not the first time that the plant leaked methyl mercaptan. Research into this matter showed that this plant has been leaking methyl mercaptan for several years. The Failure to Report The day of the accident, 23,000 pounds of methyl mercaptan escaped into the air. This number is much higher than the amount that has been released in previous leaks over the past six years, but authorities still considered past leaks to be \"significant.\" They were serious enough to be reported to the Occupational Safety and Health Administration or OSHA. The problem is that no one from DuPont ever did. The Consequences of DuPont's Failure to Act The sobering truth is that maintenance workers who have been employed at the plant since the year 2008 may have been inhaling methyl mercaptan the entire time. As a matter of fact, officials with OSHA determined that the levels of methyl mercaptan present in the air would have surpassed the level that the agency deems to be unsafe for humans. Sam Mannan of Texas A&M University's Mary Kay O'Connor Process Safety Center weighed in on this issue. According to Mannan, if DuPont's officials had shared their findings with him and his agency about their toxic leaks, those who died would possibly be alive today. He stated that if he had been given the chance, he may have been able to identify where the leak was coming from and fix it before the situation became deadly. The Texas Commission for Environmental Quality's Failure There seems to have been another failure in this matter. Officials with the Texas Commission for Environmental Quality or TCEQ issued dozens of citations to the DuPont chemical plant for several emissions violations. In turn, the agency's protocol is to notify government agencies like OSHA when officials encounter a problem that is outside of their control. Unfortunately, no government agency received notification of DuPont's violations, so OSHA was unaware that a visit to the premises would be necessary. The last time the agency performed an inspection of the DuPont chemical plant was in 2007. How the Safety Measures Failed DuPont employees filed maintenance emission reports with the TCEQ that demonstrated the fact that the company had a problem with leaks. In response, TCEQ officials were supposed to monitor the plant more often. Also, the company would have been required to enact additional safety measures and provide their workers with more training. However, DuPont did not initiate these or any other protective measures while the leaks were occurring. Although DuPont spent $18 million upgrading their equipment, clogs within the system remained. This led industrial hygienist Peter Dooley to state that DuPont did not do enough to keep its employees safe.", "domain": "chemistry", "round": 3} +{"url": "https://www.neb.com/en/protocols/2012/09/12/sample-preparation-methods-e2620", "date": "2023-12-10T22:46:38Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679102697.89/warc/CC-MAIN-20231210221943-20231211011943-00793.warc.gz", "language_score": 0.7779748439788818, "token_count": 312, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__157798755", "lang": "en", "text": "Sample Preparation Methods for PicoPLEX WGA Kit\n- Cell Sample (5 μl)\n- Wash or dilute cells with 1X PBS buffer, according to the recommendations in the Cell Specifications section of the manual.\n- If collecting cells by flow sorting: Collect a single cell into 5 μl of Cell Extraction Buffer in a PCR tube or well. If collecting cells by micromanipulation or dilution: Transfer a single cell in minimal 1X PBS volume (< 2.5 μl) to a PCR tube or well containing an appropriate volume of Cell Extraction Buffer to achieve a total cell sample volume of 5 μl.\n- Immediately freeze and store cells at -80°C or proceed directly to the Pre-Amplification Protocol.\n- Control DNA Sample (5 μl)\n- Prepare a 1 ng/μl purified DNA solution in a PCR tube or well by diluting a control DNA stock with 5 mM Tris-HCl (pH 8.0).\n- Vortex the 1 ng/μl DNA solution for 30 seconds.\n- Add 3 μl of the 1 ng/μl DNA solution to 197 μl of 5 mM Tris-HCl (pH 8.0) to prepare a 15 pg/μl DNA sample.\n- Vortex the 15 pg/μl DNA solution for 30 seconds.\n- Add 1 μl of the 15 pg/μl DNA solution to 4 μl of Cell Extraction Buffer in a PCR tube or well.", "domain": "chemistry", "round": 3} +{"url": "https://pubmed.ncbi.nlm.nih.gov/21959781/", "date": "2020-10-30T05:58:01Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-45/segments/1603107907213.64/warc/CC-MAIN-20201030033658-20201030063658-00489.warc.gz", "language_score": 0.8610438704490662, "token_count": 313, "dump": "CC-MAIN-2020-45", "global_id": "webtext-fineweb__CC-MAIN-2020-45__0__205842256", "lang": "en", "text": "The enzymes flavonoid 3'-hydroxylase (F3'H) and flavonoid 3',5'-hydroxylase (F3'5'H) play an important role in flower color by determining the B-ring hydroxylation pattern of anthocyanins, the major floral pigments. F3'5'H is necessary for biosynthesis of the delphinidin-based anthocyanins that confer a violet or blue color to most plants. Antirrhinum majus does not produce delphinidin and lacks violet flower colour while A. kelloggii produces violet flowers containing delphinidin. To understand the cause of this inter-specific difference in the Antirrhinum genus, we isolated one F3'H and two F3'5'H homologues from the A. kelloggii petal cDNA library. Their amino acid sequences showed high identities to F3'Hs and F3'5'Hs of closely related species. Transgenic petunia expressing these genes had elevated amounts of cyanidin and delphinidin respectively, and flower color changes in the transgenics reflected the type of accumulated anthocyanidins. The results indicate that the homologs encode F3'H and F3'5'H, respectively, and that the ancestor of A. majus lost F3'5'H activity after its speciation from the ancestor of A. kelloggii.", "domain": "chemistry", "round": 3} +{"url": "https://findanexpert.unimelb.edu.au/scholarlywork/1350611-comparative-stability--cytotoxicity-and-anti-leishmanial-activity-of-analogous-organometallic-sb%28v%29-and-bi%28v%29-acetato-complexes--sb-confirms-potential-while-bi-fails-the-test", "date": "2021-07-25T04:33:09Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-31/segments/1627046151563.91/warc/CC-MAIN-20210725014052-20210725044052-00682.warc.gz", "language_score": 0.8959091901779175, "token_count": 331, "dump": "CC-MAIN-2021-31", "global_id": "webtext-fineweb__CC-MAIN-2021-31__0__180287739", "lang": "en", "text": "Comparative stability, cytotoxicity and anti-leishmanial activity of analogous organometallic Sb(V) and Bi(V) acetato complexes: Sb confirms potential while Bi fails the test\nRebekah N Duffin, Victoria L Blair, Lukasz Kedzierski, Philip C Andrews\nJOURNAL OF INORGANIC BIOCHEMISTRY | ELSEVIER SCIENCE INC | Published : 2018\nA series of sixteen triphenyl Bi(V) and Sb(V) acetato complexes of general formula [MPh3(O2CCR)2] and one oxido-bridge antimony complex [(SbPh3(O2COC(O)Me))2O], have been synthesised and characterised, thirteen of which are novel. The solid-state structures of fifteen of the complexes have been successfully authenticated by single crystal X-ray diffraction. All structures, excluding the oxido-bridge antimony complex, adopt a typical trigonal bipyramidal confirmation with the phenyl rings in a propeller-like orientation in the equatorial plane. Fourteen of the complexes were screened for their anti-leishmanial activity and cytotoxicity towards mammalian cells. The Bi(V) complexes were found t..View full abstract\nAwarded by Australian Research Council\nThe authors would like to thank the Australian Research Council (DP170103624) and Monash University for financial support. We would also like to thank Dr. Craig Forsyth (Monash) for assistance with X-ray crystallography.", "domain": "chemistry", "round": 3} +{"url": "https://rrc.nbrp.jp/references/4102", "date": "2020-07-04T06:07:34Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-29/segments/1593655884012.26/warc/CC-MAIN-20200704042252-20200704072252-00398.warc.gz", "language_score": 0.6543014645576477, "token_count": 514, "dump": "CC-MAIN-2020-29", "global_id": "webtext-fineweb__CC-MAIN-2020-29__0__148305446", "lang": "en", "text": "Reference - Detail\n|Author||Kawahara A, Nishi T, Hisano Y, Fukui H, Yamaguchi A, Mochizuki N.|\n|Title||The sphingolipid transporter spns2 functions in migration of zebrafish myocardial precursors.|\nSphingosine-1-phosphate (S1P) is a secreted lipid mediator that functions in vascular development; however, it remains unclear how S1P secretion is regulated during embryogenesis. We identified a zebrafish mutant, ko157, that displays cardia bifida (two hearts) resembling that in the S1P receptor-2 mutant. A migration defect of myocardial precursors in the ko157 mutant is due to a mutation in a multipass transmembrane protein, Spns2, and can be rescued by S1P injection. We show that the export of S1P from cells requires Spns2. spns2 is expressed in the extraembryonic tissue yolk syncytial layer (YSL), and the introduction of spns2 mRNA in the YSL restored the cardiac defect in the ko157 mutant. Thus, Spns2 in the YSL functions as a S1P transporter in S1P secretion, thereby regulating myocardial precursor migration.\n|MeSH||Animals Animals, Genetically Modified Blastomeres / metabolism CHO Cells Carrier Proteins / chemistry Carrier Proteins / genetics Carrier Proteins / metabolism* Cell Movement Cricetinae Cricetulus Embryo, Nonmammalian / cytology Embryo, Nonmammalian / metabolism* Embryonic Development Heart / embryology* Heart Defects, Congenital / embryology Humans Lysophospholipids / metabolism* Membrane Proteins / chemistry Membrane Proteins / genetics Membrane Proteins / metabolism* Mesoderm / metabolism Mice Molecular Sequence Data Mutation Oligonucleotides, Antisense Organogenesis Signal Transduction Somites / embryology Somites / metabolism Sphingosine / analogs & derivatives* Sphingosine / metabolism Zebrafish / embryology* Zebrafish / genetics Zebrafish Proteins / chemistry Zebrafish Proteins / genetics Zebrafish Proteins / metabolism*|\n|WOS Category||MULTIDISCIPLINARY SCIENCES|", "domain": "chemistry", "round": 3} +{"url": "http://wikipediaaudio.com/Shibuichi", "date": "2018-03-18T07:48:51Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-13/segments/1521257645550.13/warc/CC-MAIN-20180318071715-20180318091715-00438.warc.gz", "language_score": 0.9010800719261169, "token_count": 553, "dump": "CC-MAIN-2018-13", "global_id": "webtext-fineweb__CC-MAIN-2018-13__0__222496936", "lang": "en", "text": "Aside from the basic 25% silver to 75% copper mix, combinations as divergent as 5% silver to 95% copper are also marketed as \"shibuichi\". A wide range of colours can be achieved using the whole range of alloy compositions, even above 50% silver, e.g. 90% copper and 10% silver for a dark grey and down to 70% copper and 30% silver for lighter greys.\n|name (JA)||Ag : Cu, +Au||Note mentioned colors are after patination|\n|Shibuichi||25 : 75||Dark grey, has a trace of gold|\n|60 : 40, +1||Shiro is White in JA\nlighter grey, harder, lower melting temp\n|40 : 60, +1||Ue is Upper in JA\n|30 : 70, +1||Nami is Regular in JA\nlighter than Shibuichi\n|23 : 77, +1||Darker than Shibuichi|\nKuro is black in Japanese. Kuro-Shibuichi is different from others in the table. Kuro-Shibuichi is mixture of Shibuichi (40%) and \"Shakudō (60%) with additional 1% of gold. The proportion is roughly 9.9% silver, 87.3% copper, and 2.8% gold. Kuro-Shibuich will develop black patina which is different from the black patina of Shakudo.\nIt is a common misconception that both copper and silver oxides form, but in fact a detailed study has shown that only copper oxides are formed on the copper rich regions of the material's microstructure, while the silver rich regions are left largely untouched.[\"citation needed]\nThe first official mention of the material is from the early 18th century, in documents from the State Mint, though it is believed to have existed before that. For most of its history, shibuichi was mostly used to ornament various fittings for \"katana until the \"Meiji reforms, when most swordmakers began to make purely decorative objects instead. The material is often used in \"mokume-gane combinations. Similar alloys have been used elsewhere but the use of shibuichi to achieve different colored patinas appears to have remained nearly unknown outside Japan, until recent interest from artisans in the West.\n|Wikimedia Commons has media related to Shibuichi.|\n|\"\"||This article related to art or architecture in Japan is a \"stub. You can help Wikipedia by expanding it.|\n|\"\"||This alloy-related article is a \"stub. You can help Wikipedia by expanding it.|", "domain": "chemistry", "round": 3} +{"url": "https://www.duo.uio.no/handle/10852/254/browse?value=Waaler%2C+Jo&type=author", "date": "2020-09-21T03:57:01Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-40/segments/1600400198887.3/warc/CC-MAIN-20200921014923-20200921044923-00107.warc.gz", "language_score": 0.7007550597190857, "token_count": 338, "dump": "CC-MAIN-2020-40", "global_id": "webtext-fineweb__CC-MAIN-2020-40__0__60359869", "lang": "en", "text": "Browsing Øvrige samlinger by Author \"Waaler, Jo\"\nVehus, Tore; Waaler, Jo; Krauss, Stefan; Lundanes, Elsa; Wilson, Steven Ray Haakon (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)Fluorescence polarization (FP) is a highly regarded technique for studying drug–protein interactions, but has limited value regarding protein mixtures. As a novel approach to drug target discovery, the possibility of ...\nThe tankyrase inhibitor G007-LK inhibits small intestine LGR5+ stem cell proliferation without altering tissue morphology Norum, Jens Henrik; Skarpen, Ellen; Brech, Andreas; Kuiper, Raoul; Waaler, Jo; Krauss, Stefan; Sørlie, Therese (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)Background: The WNT pathway regulates intestinal stem cells and is frequently disrupted in intestinal adenomas. The pathway contains several potential biotargets for interference, including the poly-ADP ribosyltransferase ...\nVersatile, sensitive liquid chromatography mass spectrometry–Implementation of 10 μm OT columns suitable for small molecules, peptides and proteins Vehus, Tore; Røberg-Larsen, Hanne; Waaler, Jo; Aslaksen, Sigrid; Krauss, Stefan; Wilson, Steven Ray Haakon; Lundanes, Elsa (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)", "domain": "chemistry", "round": 3} +{"url": "https://kurslashes-yandex.ru/optical-dating-of-granite-stone-surfaces-3656.html", "date": "2021-05-06T02:45:11Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-21/segments/1620243988725.79/warc/CC-MAIN-20210506023918-20210506053918-00243.warc.gz", "language_score": 0.9245755076408386, "token_count": 435, "dump": "CC-MAIN-2021-21", "global_id": "webtext-fineweb__CC-MAIN-2021-21__0__87445241", "lang": "en", "text": "Optical dating of granite stone surfaces\nGranite is nearly always massive (i.e., lacking any internal structures), hard, and tough.\nThese properties have made granite a widespread construction stone throughout human history.\nWhen a granitoid is devoid or nearly devoid of plagioclase, the rock is referred to as alkali feldspar granite.\nWhen a granitoid contains less than 10% orthoclase, it is called tonalite; pyroxene and amphibole are common in tonalite.\nA worldwide average of the chemical composition of granite, by weight percent, based on 2485 analyses: Granite rock in the cliff of Gros la Tête – Aride Island, Seychelles.\nThe thin (1–3 cm wide) brighter layers are quartz veins, formed during the late stages of crystallization of granitic magmas.\nA granite containing both muscovite and biotite micas is called a binary or two-mica granite.\nTwo-mica granites are typically high in potassium and low in plagioclase, and are usually S-type granites or A-type granites.\nLike granite, soap is not recommended for regular cleaning since residue will build up and leave a dull film.\nThe average density of granite is between 2.65 and 2.75 g/cm Granite is classified according to the QAPF diagram for coarse grained plutonic rocks and is named according to the percentage of quartz, alkali feldspar (orthoclase, sanidine, or microcline) and plagioclase feldspar on the A-Q-P half of the diagram.\nTrue granite (according to modern petrologic convention) contains both plagioclase and alkali feldspars.\nAlso, many people prefer a uniform pattern that is exactly the same over the entire surface. Cost is not really an issue when comparing to granite since you'll pay about the same for engineered stone.\nQuartz countertops from all the brands are a snap to clean.", "domain": "chemistry", "round": 3} +{"url": "https://www.thermofisher.com/antibody/product/Phospho-SYT1-pThr202-SYT2-pThr199-Antibody-Polyclonal/PA5-37830", "date": "2017-03-25T21:55:37Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-13/segments/1490218189083.86/warc/CC-MAIN-20170322212949-00008-ip-10-233-31-227.ec2.internal.warc.gz", "language_score": 0.777894914150238, "token_count": 477, "dump": "CC-MAIN-2017-13", "global_id": "webtext-fineweb__CC-MAIN-2017-13__0__217765676", "lang": "en", "text": "Note: You clicked on an external link, which has been disabled in order to keep your shopping session open.\n|Tested species reactivity||Human, Mouse, Rat|\n|Host / Isotype||Rabbit / IgG|\n|Immunogen||Peptide sequence around phosphorylation site of threonine 202/199 (R-K-T(p)-L-N) derived from Human Synaptotagmin 1/2 .|\n|Storage buffer||PBS, pH 7.4, with 50% glycerol|\n|Contains||0.02% sodium azide|\n|Tested Applications||Dilution *|\n* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.\nA suggested positive control for ICC/IF is Hela cells.\nMay have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2.\nFor Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.\nFLJ42519; Inositol polyphosphate-binding protein; IP4-binding protein; p65; synaptotagmin 1; synaptotagmin 2; Synaptotagmin I; Synaptotagmin II; Synaptotagmin-1; Synaptotagmin-2; SYT2; SytI; SytII\nAW124717; CMS7; G630098F17Rik; mKIAA4194; MYSPC; P65; R74640; RATSYNII; SVP65; SYNII; SYT; SYT1; SYT2; SytI; SytII", "domain": "chemistry", "round": 3} +{"url": "https://www.creative-diagnostics.com/Anti-HP-PAb-197846-490.htm", "date": "2018-03-23T11:01:25Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-13/segments/1521257648207.96/warc/CC-MAIN-20180323102828-20180323122828-00377.warc.gz", "language_score": 0.7714303135871887, "token_count": 398, "dump": "CC-MAIN-2018-13", "global_id": "webtext-fineweb__CC-MAIN-2018-13__0__209436775", "lang": "en", "text": "Anti-Haptoglobin polyclonal antibody (DPABH-24988)\nGoat Anti-Human Haptoglobin polyclonal antibody for IHC-P\nBring this labeled antibody directly to your bench!\nOnline Inquiry Add to basket\nPurified Human Haptoglobin\nIHC-P: 2.5 μg/ml.\n*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.\nHP; haptoglobin; BP; HPA1S; HP2ALPHA2; zonulin\nBinding and Uptake of Ligands by Scavenger Receptors; amb2 Integrin signaling;\nHave you cited DPABH-24988 in a publication? Let us know\nand earn a reward for your research.\nYue, TT; Partyka, K; et al. Identification of blood-protein carriers of the CA 19-9 antigen and characterization of prevalence in pancreatic diseases. PROTEOMICS 11:3665-3674(2011).\nPerez, C; Ortuno, E; et al. Cloning and expression of porcine CD163: its use for characterization of monoclonal antibodies to porcine CD163 and development of an ELISA to measure soluble CD163 in biological fluids. SPANISH JOURNAL OF AGRICULTURAL RESEARCH 6:59-72(2008).\nCustom Antibody Labeling\nWe offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody.", "domain": "chemistry", "round": 3} +{"url": "https://nipexnig.com/technologies/how-much-methane-is-released-by-fracking.html", "date": "2021-10-22T16:08:26Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-43/segments/1634323585516.51/warc/CC-MAIN-20211022145907-20211022175907-00290.warc.gz", "language_score": 0.9213536381721497, "token_count": 340, "dump": "CC-MAIN-2021-43", "global_id": "webtext-fineweb__CC-MAIN-2021-43__0__9685378", "lang": "en", "text": "New data from a fracking site in Blackpool has revealed the extent of the industry’s environmental footprint, with researchers tracing a huge 4.2-tonnes of methane gas release over a weeklong period in January 2019. This is the equivalent to more than 140 transatlantic flights.\nHow much methane is released naturally?\nDuring 2019, about 60% (360 million tons) of methane released globally was from human activities, while natural sources contributed about 40% (230 million tons).\nDoes fracking leak methane?\nThe chemical signature of methane released from fracking is found in the atmosphere, pointing to shale gas operations as the culprit. Scientists have measured big increases in the amount of methane, the powerful global warming gas, entering the atmosphere over the last decade.\nIs fracking worse than drilling?\nFracking requires more water than conventional gas drilling; but when natural gas is used in place of coal or nuclear fuel to generate electricity, it saves water. … Unconventional drilling’s water demand can be better or worse than alternative energy sources, the study finds.\nDoes fracking destroy the environment?\nFracking is a hotly debated environmental and political issue. Advocates insist it is a safe and economical source of clean energy; critics, however, claim fracking can destroy drinking water supplies, pollute the air, contribute to the greenhouse gases that cause global warming, and trigger earthquakes.\nIs fracking worse than coal?\nFracking is a process that splits deposits of natural gas deep underground, using high pressure chemicals. A new study at Cornell has revealed that the process releases large quantities of methane, and other harmful gases, yielding 20% more global warming per unit than coal.", "domain": "chemistry", "round": 3} +{"url": "https://pubs.er.usgs.gov/publication/70199586", "date": "2019-10-17T02:49:42Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-43/segments/1570986672548.33/warc/CC-MAIN-20191017022259-20191017045759-00378.warc.gz", "language_score": 0.883327066898346, "token_count": 415, "dump": "CC-MAIN-2019-43", "global_id": "webtext-fineweb__CC-MAIN-2019-43__0__79673594", "lang": "en", "text": "Distribution of reduction-oxidation conditions and relation to trends in nitrate in groundwater, Central-Eastside San Joaquin Valley, California\nA 2,700 km2 study area in the eastern San Joaquin Valley near Modesto, California, was investigated to: describe three-dimensional reduction-oxidation (redox) conditions by using water chemistry data compiled from multiple sources; analyze relations of redox conditions to explanatory factors; and determine relations between nitrate (NO3) trends and redox conditions and other factors. Redox conditions are primarily oxic, but increasingly anoxic conditions were correlated with proximity to the valley center, decreased depth to water, and areas of historical groundwater discharge. Anoxic conditions in areas with shallow depths to water occur in both modern recharge, which has abundant organic carbon as an electron donor due to interactions of the shallow water table with soils, and pre-modern groundwater in discharge areas. Although NO3 concentrations were significantly less in wells with anoxic than oxic or mixed redox conditions, dissolved N2 gas data from 39 wells indicate that denitrification caused NO3 concentrations to decrease from above to below the drinking water threshold in only 1 well (maximum excess N2-N of 11 mg/L), indicating that denitrification does not currently protect many wells from NO3 contamination. Trends in NO3 concentrations showed only minor relations to redox conditions. Although NO3 concentrations and trends in the study area are primarily controlled by loading from agricultural land use rather than by redox conditions, greater understanding of the factors controlling the distribution of redox conditions contributes to efforts to simulate NO3 transport at a regional scale.\nAdditional publication details\n|Publication Subtype||Journal Article|\n|Title||Distribution of reduction-oxidation conditions and relation to trends in nitrate in groundwater, Central-Eastside San Joaquin Valley, California|\n|Series title||Hydrogeology Journal|\n|Contributing office(s)||California Water Science Center|\n|Other Geospatial||San Joaquin Valley|", "domain": "chemistry", "round": 3} +{"url": "https://www.thedonutwhole.com/how-much-spinach-a-day-is-safe/", "date": "2024-03-03T12:01:38Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707947476374.40/warc/CC-MAIN-20240303111005-20240303141005-00419.warc.gz", "language_score": 0.8853449821472168, "token_count": 1828, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__117456844", "lang": "en", "text": "The recommended daily intake of spinach is 1-2 cups per day, which provides numerous vitamins, minerals and antioxidants. Eating more than 3-4 cups per day long-term may cause issues due to the oxalic acid content. Cooking the spinach reduces the oxalic acid content.\nHow Much Spinach Is Too Much?\nEating 1-2 cups of raw or cooked spinach per day is considered safe and healthy. This provides a good amount of nutrients without going overboard on oxalic acid.\nConsuming more than 3-4 cups per day, especially raw spinach, could potentially cause some negative effects in sensitive individuals due to the higher oxalic acid content. Oxalic acid can bind to calcium and reduce its absorption. It may also contribute to kidney stone formation in those prone to them.\nTherefore, it’s best to keep spinach intake to about 1-2 cups daily as part of a balanced diet. This gives you plenty of nutritional benefits without any significant downsides.\nOxalic Acid Content of Spinach\nSpinach contains moderate amounts of oxalic acid, an antinutrient that can bind to minerals like calcium and iron in the digestive tract, reducing their absorption.\nHere is the oxalic acid content of spinach varieties (1):\n|Total Oxalic Acid (mg per 100g)\nAs you can see, raw spinach contains the highest amounts of oxalic acid. Boiling spinach can reduce the oxalic acid content by 70% (2).\nTherefore, cooking methods like boiling, steaming or sautéing are best for reducing oxalates while retaining nutrients.\nFactors That Affect Oxalic Acid Content\nThe oxalic acid content of spinach is affected by the following factors:\n– Cooking method – boiling, steaming and sautéing reduce oxalates. Raw has the highest.\n– Maturity of spinach – younger leaves tend to be higher in oxalates.\n– Growing conditions – factors like soil composition, sunlight exposure, climate and use of fertilizers can impact oxalate levels.\n– Storage time – longer storage times increase oxalic acid content.\nGiven these variables, oxalate levels can range from 400-1200mg per 100g portion of spinach (3).\nPotential Effects of High Oxalic Acid Intake\nFor most people, moderate spinach intake won’t cause any issues. However, eating very high amounts for prolonged periods may potentially cause:\n– Reduced absorption of minerals like calcium, iron and zinc. This can contribute to nutritional deficiencies long-term (4).\n– Increased risk of kidney stones in those with a history of them. Oxalic acid can bind to calcium to form calcium oxalate, the most common type of kidney stones (5).\n– Irritation of the mouth, throat and digestive tract. Oxalic acid is a naturally irritating compound.\n– Hypocalcemia (low blood calcium). This is rare, but has been reported in a few cases of very high oxalic acid intake over long periods (6).\nHowever, keep in mind that these effects only occur at very high intakes consumed regularly over long periods, such as 6 cups or more per day.\nEating normal amounts of spinach as part of a balanced diet is very unlikely to cause issues in healthy individuals.\nTips to Reduce Oxalic Acid in Spinach\nHere are some preparation tips to reduce the oxalic acid content of spinach:\n– Boil, steam or sauté instead of eating raw. Cooking can reduce oxalates by up to 70% (7).\n– Avoid boiling with baking soda. This causes greater losses of nutrients (8).\n– Discard cooking water after boiling to remove some of the oxalic acid.\n– Focus on younger, smaller leaves which tend to be lower in oxalates.\n– Rinse well before cooking to remove residual oxalates on leaves.\n– Cook for at least a few minutes to maximize oxalate reduction.\n– Consider lightly roasting or grilling spinach leaves as well.\n– Freeze spinach after blanching for use later. This deactivates oxalate oxidase, an enzyme that converts to oxalic acid.\nFollowing these steps allows you to reduce the amount of antinutrients while retaining nutrition in spinach.\nHealth Benefits of Spinach\nHere are some of the top health benefits associated with eating spinach:\n– Excellent source of vitamin K. One cup of raw spinach provides over 150% of the RDI for vitamin K, which supports bone and heart health (9).\n– Good source of vitamin A. Spinach provides over 50% of the RDI for vitamin A per cooked cup, mostly as beta carotene. Vitamin A supports immune function and vision (10).\n– Dense in folate. Folate helps make DNA and produce red blood cells. A cup of cooked spinach provides almost 40% of the RDI for folate (11).\n– Contains lutein and zeaxanthin. These antioxidants help prevent eye conditions like cataracts and macular degeneration (12).\n– Rich in nitrates. Spinach contains high levels of nitrates, which may improve circulation and oxygen use during exercise (13).\n– Nutritious minerals. Spinach provides many minerals like magnesium, iron, potassium and manganese.\n– High in antioxidants. In addition to vitamin A, spinach contains flavonoids and carotenoids with antioxidant activity.\nOverall, spinach is one of the most nutrient-dense vegetables you can eat. The nutritional benefits far outweigh any antinutrient effects.\nNutrition Facts for Spinach\nHere are the nutrition facts for 1 cup (30g) of raw spinach and 1 cup (180g) of boiled spinach (14):\nAs you can see, boiling spinach increases the concentration of most nutrients, except for vitamin C which decreases slightly with cooking.\nDaily Recommendations for Spinach Intake\nBased on its nutrition profile and oxalic acid content, here are some evidence-based spinach intake recommendations:\n– 1-2 cups per day of cooked spinach is great for most healthy people as part of a balanced diet. This gives you plenty of nutritional benefits without going overboard on antinutrients.\n– Limit raw spinach intake to around 1 cup per day. Cooking is best for reducing oxalates.\n– Drink plenty of fluids daily to reduce any kidney stone risk if you eat spinach regularly.\n– Avoid excessive spinach juice or smoothie consumption. Better to eat it cooked instead.\n– If you have a history of calcium oxalate kidney stones, limit high-oxalate foods and consult your doctor about spinach intake.\n– Pregnant women can eat normal amounts of spinach as part of a varied diet. No evidence suggests a need to avoid it.\n– People with hypocalcemia or on dialysis due to kidney disease may need to restrict spinach intake and limit oxalates. Check with your doctor.\nFor most individuals, moderate spinach consumption offers great health benefits and poses little risk unless eaten in extreme excess for prolonged periods.\nCan Babies Eat Spinach?\nSpinach can be introduced to most babies around 6 months of age as a complementary food after starting with iron-fortified cereals and purees (15).\nIt’s recommended to start with small amounts of cooked spinach pureed or mashed initially. Cook it thoroughly and don’t add any salt, spices or sugar.\nYou can gradually increase the portion size and transition to chopped spinach over time as their digestive system matures.\nMany pediatricians recommend introducing higher oxalate foods like spinach after foods like avocado, applesauce, peas, carrots and squash since they’re lower in antinutrients.\nSince an infant’s digestive system is immature, it’s ideal to limit spinach intake to a few times a week versus daily for the first year. Also avoid raw spinach for babies given the higher oxalate content.\nSpeak to your pediatrician about when and how to introduce spinach to get personalized advice based on your child. Most babies can tolerate cooked spinach well in age-appropriate amounts as part of a varied diet.\nThe Bottom Line\n1-2 cups of cooked spinach per day is a healthy intake for most people. This provides plenty of beneficial vitamins, minerals, fiber and antioxidants without excessive oxalic acid.\nCooked spinach is preferable to raw for reducing oxalate content, but both can be included in moderation as part of a balanced diet. Those prone to kidney stones should limit high-oxalate foods.\nGiven its stellar nutritional profile, spinach is one of the healthiest foods you can eat. The key is consuming moderate amounts and using cooking methods that reduce antinutrient levels.", "domain": "chemistry", "round": 3} +{"url": "https://www.mdpi.com/2077-0375/5/3/307", "date": "2018-10-23T02:02:14Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-43/segments/1539583515564.94/warc/CC-MAIN-20181023002817-20181023024317-00272.warc.gz", "language_score": 0.7130124568939209, "token_count": 580, "dump": "CC-MAIN-2018-43", "global_id": "webtext-fineweb__CC-MAIN-2018-43__0__199171132", "lang": "en", "text": "Aquaporin-Based Biomimetic Polymeric Membranes: Approaches and Challenges\nAbstractIn recent years, aquaporin biomimetic membranes (ABMs) for water separation have gained considerable interest. Although the first ABMs are commercially available, there are still many challenges associated with further ABM development. Here, we discuss the interplay of the main components of ABMs: aquaporin proteins (AQPs), block copolymers for AQP reconstitution, and polymer-based supporting structures. First, we briefly cover challenges and review recent developments in understanding the interplay between AQP and block copolymers. Second, we review some experimental characterization methods for investigating AQP incorporation including freeze-fracture transmission electron microscopy, fluorescence correlation spectroscopy, stopped-flow light scattering, and small-angle X-ray scattering. Third, we focus on recent efforts in embedding reconstituted AQPs in membrane designs that are based on conventional thin film interfacial polymerization techniques. Finally, we describe some new developments in interfacial polymerization using polyhedral oligomeric silsesquioxane cages for increasing the physical and chemical durability of thin film composite membranes. View Full-Text\n- Supplementary File 1:\nSupplementary (PDF, 77 KB)\nShare & Cite This Article\nHabel, J.; Hansen, M.; Kynde, S.; Larsen, N.; Midtgaard, S.R.; Jensen, G.V.; Bomholt, J.; Ogbonna, A.; Almdal, K.; Schulz, A.; Hélix-Nielsen, C. Aquaporin-Based Biomimetic Polymeric Membranes: Approaches and Challenges. Membranes 2015, 5, 307-351.\nHabel J, Hansen M, Kynde S, Larsen N, Midtgaard SR, Jensen GV, Bomholt J, Ogbonna A, Almdal K, Schulz A, Hélix-Nielsen C. Aquaporin-Based Biomimetic Polymeric Membranes: Approaches and Challenges. Membranes. 2015; 5(3):307-351.Chicago/Turabian Style\nHabel, Joachim; Hansen, Michael; Kynde, Søren; Larsen, Nanna; Midtgaard, Søren R.; Jensen, Grethe V.; Bomholt, Julie; Ogbonna, Anayo; Almdal, Kristoffer; Schulz, Alexander; Hélix-Nielsen, Claus. 2015. \"Aquaporin-Based Biomimetic Polymeric Membranes: Approaches and Challenges.\" Membranes 5, no. 3: 307-351.", "domain": "chemistry", "round": 3} +{"url": "http://www.conversion-website.com/density/from-pound-per-cubic-inch.html", "date": "2017-01-16T10:51:30Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-04/segments/1484560279169.4/warc/CC-MAIN-20170116095119-00495-ip-10-171-10-70.ec2.internal.warc.gz", "language_score": 0.6980547308921814, "token_count": 367, "dump": "CC-MAIN-2017-04", "global_id": "webtext-fineweb__CC-MAIN-2017-04__0__26252068", "lang": "en", "text": "Pound per cubic inch conversionsdensity conversions » pound per cubic inch conversions\nThe online converter calculator on this page allows you to select the density measurement unit you want to convert to starting from pounds per cubic inch (lb/cu in). To make a conversion starting from a unit of density other than pound per cubic inch, simply click on the \"Reset\" button.\nWhat is pound per cubic inch?\nThe pound per cubic inch is a unit of density equal to 27,679.904 kilograms per cubic meter (1 lb/cu in = 27,679.904 kg/m3), the derived unit of density in the International System of Units (SI). It is also equal to 27.679904 kilograms per cubic decimeter (kg/dm3), or 27,679.904 grams per cubic decimeter (g/dm3), or 27.679904 grams per cubic centimeter (g/cm3), or 27.679904 kilograms per liter (kg/L), or 27,679.904 grams per liter (g/L) or 27.679904 grams per milliliter (g/mL).\nThe density of a material expresses the mass of the material per unit of volume. Thus, the pounds per cubic inch (or pounds/cubic inch) show how many pounds of material are in a volume of one cubic inch. The pound (or international avoirdupois pound) is a unit of mass in the Imperial and US customary systems of units while the cubic inch is a unit of volume in the Imperial and US customary systems of units.\npounds per cubic inch\nBelow you can find a comprehensive list with conversions from pounds per cubic inch to other (metric, imperial, or customary) density measurement units.", "domain": "chemistry", "round": 3} +{"url": "http://www.docstoc.com/docs/25449986/List-of-Abstracts-Received", "date": "2014-03-10T04:16:13Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2014-10/segments/1394010623118/warc/CC-MAIN-20140305091023-00085-ip-10-183-142-35.ec2.internal.warc.gz", "language_score": 0.653201162815094, "token_count": 11398, "dump": "CC-MAIN-2014-10", "global_id": "webtext-fineweb__CC-MAIN-2014-10__0__142933948", "lang": "en", "text": "\"List of Abstracts Received\"\nNANOPOROUS MATERIALS – IV Niagara Falls, Ontario, Canada June 7 – 10, 2005 List of Abstracts Received 001 New Efficient Al-containing SBA-15 Materials for Removing Nitrosamines in Mild Conditions C.F. Zhou, Y.M. Wang, T.T. Zhuang, Y. Wang and J.H. Zhu P. R. China 002 Functionallization of Silica by in-situ Grafting Hydrotalcite A. Ji, L.Y. Shi, Y. Cao and Y. Wang P. R. China 003 Preparation of Mesostructured Lamellar Zirconia L.Y. Shi, L. Gao, A. Ji and Y. Wang P. R. China 004 Heterogenization of Molybdovanadophosphoric Acids on Amine-functionalized SBA-15 P. Manikandan, N. K. Kala Raj, S. S. Deshpande, Rohit H. Ingle and T. Raja India 005 Direct Synthesis of Copper-modified MCM-41 Functional Materials Z.Y. Wu, Y.M. Wang and J.H. Zhu P. R. China 006 Generating the Selective Adsorptive Sites on Activated Carbon Y. Cao, L.Y. Shi, C.F. Zhou, T.T. Zhuang, Y. Wang and J.H. Zhu P. R. China 007 Aluminum-assisted Mesopore Formation in MFI Zeolites during Desilication in Alkaline Medium J.C. Groen, L.A.A. Peffer,1 J.C. Jansen,1 J.A. Moulijn and J. Pérez-Ramírez The Netherlands, Norway 008 Controlling Morphological, Orientational and Material Properties of Mesoporous Aluminosilicate Films: Enabling Supercritical Fluid Deposition of Perpendicularly Ordered Nanowire Arrays Kevin M. Ryan, Daniel M. Lyons, Justin D. Holmes and M. A. Morris Ireland 009 Immobilization of Tungstophosphoric Acid in SBA-15 Mesoporous Materials Nong-Yue He and Ho-In Lee P. R. China, South Korea 010 Catalytically Formation of Acetic Anhydride over Tungstophosphoric Acid Modified SBA-15 Mesoporous Materials Nong-Yue He and Ho-In Lee P. R. China, South Korea 011 Photodegradation of Organic Compounds with Different Molecular Sizes in Water over TiO2 Supported On Activated Carbon Fibers Rusheng Yuan, Rongbo Guan and Jingtang Zheng P. R. China 012 Preparation of Mesoporous Carbon by Catalytic Steam Activation with Copper, Yttrium and Cerium Oxides Jingtang Zheng and Wenzhong Shen P. R. China 013 Preparation of High Surface Area Mesoporous Activated Carbon Fiber and Its Adsorption Properties of Sulfides From Light Oil Wenzhong Shen and Jingtang Zheng P. R. China 014 Functionalization of HMS Mesoporous Molecular Sieves and Their Base-Catalytic Performance Chun Yang P. R. China 015 The Sorption of Butanes over Carbon Nanotubes Zs. Ötvös, Gy. Onyestyák, J. Valyon, I. Kiricsi and L.V.C. Rees Hungary, Scotland 016 Destruction of Trichlorophenol Using Novel Nanostructured Manganese-Cerium SBA-15 Based Catalysts M. Abecassis-Wolfovich, M.V. Landau, A. Brenner and M. Herskowitz Israel 017 A New Family of Aluminoborates Containing Octahedral Open Framework Jing Ju, Jianhua Lin and Toyota Naoki P. R. China, Japan 018 Mass Spectrum Study on Degradation of Nitrosamines over Modified Zeolites S.L. Zhou, Y. Cao, H.D. Liu, Y. Wang and J.H. Zhu P. R. China 019 New Nanoparticle / LDH Composite Materials as Precursors of Metal Supported Catalysts C. Gérardin, D. Kostandinova, N. Sanson, N. Tanchoux, D. Tichit and B. Coq France 020 Mesoporous Silicalite-1 Nanocasted by Carbon with Inverse Opal Structure M. Wallau, A. A. Campos, L. Dimitrov and E A. Urquieta-González Brazil, Bulgaria 021 Mesoporous Carbon Prepared by Nanocasting of MCM-41 and MCM-48 Nanospheres M. Wallau, A. A. Campos, L. Dimitrov and E. A. Urquieta-González firstname.lastname@example.org Brazil, Bulgaria 022 Adsorption of VOC’s on Surface-Modified Mesoporous Silica Rodrigo Sarna, Peter Harlick and Abdelhamid Sayari Canada 023 “Building Block” Approach to Functionalization of Porous Materials Sheng Dai USA 024 Pt Promoted W/Zr Mixed Oxide Supported on Mesoporous SBA-15 in n-Pentane Isomerization – Effect of Preparation Method Wenchao Lee and Soofin Cheng Taiwan 025 Acid-free Synthesis of Mesotructured Silica Materials Shih-Yuan Chen and Soofin Cheng Taiwan 026 The Generation of Mesoporous CeO2 with Crystalline Pore Walls Using Novel Block Copolymer Templates B. Smarsly, T. Brezesinski, M. Antonietti, D. Grosso, C. Boissière and C. Sanchez Germany, France 027 A Dry Gel Synthesis Route to Mesoporous ZSM-5 Catalysts Yi Hsin Chou, Colin S. Cundy and Arthur A. Garforth United Kingdom 028 Determination of Cardiac Troponin I by Anodic Stripping Voltammetry at SBA-15 Mesoporous Modified Carbon Paste Electrode Hui-Shi Guo, Ji-Nan Zhang, Di Yang, Peng-Feng Xiao and Nong-Yue He P. R. China 029 Nonoxidative Dehydroaromatization Reaction of Methane to Benzene over Mo-based Catalysts Supported on MCM-41 and MCM-22. Azfar Hassan and Abdelhamid Sayari Canada 030 Functionalized Mesoporous SBA-15 Silica Molecular Sieves with Mercaptopropyl Groups: Preparation, Characterization and Application as Adsorbents Zhaohua Luan, Jay Fournier, Jan Wooten, Donald Miser and Michael Chang USA 031 Synthesis of Mesoporous Bis(triethoxysilylethen-2-yl)benzene Material with Molecular Order in the Pore Walls Wenhui Wang and Abdelhamid Sayari Canada 032 SBA-15 Templated-Ordered Mesoporous Carbon: Effect of SBA-15 Microporosity Yong Yang and Abdelhamid Sayari Canada 033 Synthesis and Characterization of Vinyl-Functionalized SBA-15 by a Novel Direct Synthesis Grafting Method Byungkyu Park, Seung-Su Park, Il Kim and Chang-Sik Ha Korea 034 Synthesis and Characterization of Tinanium-Substituted Hybrid Periodic Mesoporous Organosilicas Woojin Cho, Il Kim and Chang-Sik Ha Korea 035 Effect of Exchangeable Cation and Hydration Layer on the Swelling Property of 2:1 Dioctahedral Smectite – A Periodic First Principle Study Abhijit Chatterjee, Fujio Mizukami and Akira Miyamoto Japan 036 Preparation and Electrorheological Property of Conducting Copolyaniline/MCM-41 Nanocomposite M. S. Cho, H. J. Choi and W. S. Ahn Korea 037 Supercritical Carbon Dioxide as Medium for the Formation of Gold Nanoparticles into MCM-41and Its Catalytic Activity M. Chatterjee and Y. Ikushima Japan 038 Silica Films with a Single-Crystalline Mesoporous Structure Hirokatsu Miyata, Takashi Suzuki, Ayumu Fukuoka, Takeshi Sawada, Masatoshi Watanabe, Takashi Noma, Kazuhiro Takada, Taihei Mukaide and Kazuyuki Kuroda Japan 039 Synthesis and Optimization of Ordered Microporous Carbon Adsorbents Louis Chen, Ranjeet Singh and Paul Webley Australia 040 The Preparation and Characterization of Mesostructured Thin Films of Perovskites and Ternary Oxides T. Brezesinski, D. Grosso,2 B. Smarsly, M. Antonietti, C. Boissière, C. Sanchez , H. Amentisch and P. A. Albouy Austria, France, Germany 041 Synthesis of Mesostructured Aluminum Organophosphonates Prepared by Using Organically Bridged Diphosphonic Acids Tatsuo Kimura Japan 042 Preparation of Film-, Rod- and Fiberliker SBA-15 Mesoporous Silica in the Presence of Phosphoric Acid Wenjiang Li, Raghuraman Pitchumani, Marc-Olivier Coppens The Netherlands 043 Parsite: A New Nanoporous Aluminophosphate Cavus Falamaki Iran 044 Dye-modified Mesoporous Zinc Oxide Thin Films Prepared by Electrochemical Self-Assembly J. Rathousky, T. Loewenstein, K. Nonomura, T. Yoshida, M. Wark and D. Schlettwein Czech Republic, Germany, Japan 045 Preparing the Composites with Tunable Pore Sizes around 2 nm Qi Jiang, Yi Cao, Ting Ting Zhuang and Jian Hua Zhu P. R. China 046 Oxidation of Trimethylphenol over Mesoporous Titanosilica TS-1 Catalysts D. Das and A. Sayari Canada 047 A Novel Organic-Inorganic Hybrid Porous Material Y. Wang, J. Liu, A. Ji, L.Y. Shi, L. Gao and X.W. Han P.R. China 048 Preparation of Mesostructured Silica Using a Nonionic Fluorinated Surfactant: Correlation between Mesoporous Characteristics and Surfactant Phase Behavior J.L. Blin and M.J. Stébé France 049 Functionalization of Mesoporous Silica by Condensation of Tetramethoxysilane and Alkyl Peptidoamines Monomers in The Presence Of a Non-Ionic Fluorinated Surfactant J.L. Blin, C. Gérardin, L. Rodehüser, C. Selve and M.J. Stébé France 050 Synthesis and Functionalization of Mesoporous Silicas by Thiol Groups for Heavy Metal Sorbents C. Lesaint, F. Frébault, B. Lebeau, C. Marichal, J. Patarin, C. Delacôte, A. Walcarius France 051 Metathesis of 1-Hexene over MoO3 Supported Mesostructured γ-Al2O3 Prepared with Cationic Surfactants J. Aguado, J. M. Escola, M. C. Castro and B. Paredes Spain 052 Diels-Alder Cycloadditions of Single-Wall Carbon Nanotubes and Fullerenes with Electron-Rich Dienes Warakulwit, C., Bamrungsap, S., Luksirikul, P., Khongpracha, P. and Limtrakul, J. Thailand 053 Adsorption of Benzene on MCM-41-type Materials: A QM/MM Study Bavornpon Jansang and Jumras Limtrakul Thailand 054 Hollow Hexagonal Shells of Porous Carbon with Graphitic Framework Nanocast Using Zeolite β via Chemical Vapour Deposition Zhuxian Yang, Yongde Xia, and Robert Mokaya United Kingdom 055 Isolation, Characterization and Modification of Clay Solids from Oil Sand Wastes Abdul Majid, Steve Argue and Jim Margeson Canada 056 Mesostructured Aluminosilica Oxynitrides: Synthesis and Characterization of MCM-41 Solid Acid-Base Materials Yongde Xia and Robert Mokaya United Kingdom 057 Hydrotalcite (HT) and Mesoporous Mixed Oxides Obtained From HT Basic Solid Catalysts for Cyclohexanone Condensation E. Angelescu, R. Birjega, O. D. Pavel, M. Che, G. Costentin and S. Popoiu Romania, France 058 Nanoporous Organosilica Adsorbents for Selective Detection of Aromatic Compounds Michael A. Markowitz, Mazyar Zeinali, Shalini Jayasundera and Mark S. Spector USA 059 Synthesis and Characterization of Intercalated Mesostructure PANI/V2O5 Li Li and Zi-Feng Yan P. R. China 060 N-(hydroxylethyl)pyrrolidone Dehydration Performance on REOx Doped Nano-ZrO2 Catalyst Lei Zhang, Xin-Mei Liu and Zi-Feng Yan P. R. China 061 Encapsulation of Organic Dyes in Nanoporous Silica Shapes Yaroslav Yu. Kievsky and Igor Yu. Sokolov USA 062 Origami Model of Synthesis of 3D Self-Assembled Nanoporous Colloids: Direct Proof Yaroslav Yu. Kievsky and Igor Yu. Sokolov USA 063 Design 3D Self-Assembled Nanoporous Colloids Igor Yu. Sokolov USA 064 How Copper Promotes the Adsorption of Nitrosamines in SBA-15? J.H. Xu, T.T. Zhuang, Z.Y. Wu, Y.L. Wei and J.H. Zhu P.R. China 065 Photoluminescence Property of Eu(bpy)23+ Dispersed in Mesoporous Materials SBA-15 Shu-Xun Ge, Nong-Yue He and Chun Yang P.R. China 066 Microemulsion Templated Mesoporous Silica: Characterisation via Small Angle X-Ray Scattering and Stability in Aqueous Buffers S. Boskovic, J. Connolly, C.E. Buckley, T.W. Turney, M.L. Gee, G.W. Stevens and A. J. O’Connor Australia 067 Molecular Dynamics Simulation Studies of Adsorption and Diffusion of p-Xylene in Si-MCM-41 T. Nanok, P. A. Bopp and J. Limtrakul France, Thailand 068 Morphological Change of PMO and SBA-15 by Metamorphic Reconstruction S. S. Park, S. J. Kim and D. H. Park Korea 069 Fabrication and Porocity Control of Mesoporous Polycarbosilane from SBA-15 Templated Polymethylsilane J. H. Cheon, S. J. Kim, Y.-K. Seo and D. H. Park Korea 070 Aluminosilicate Macro-Channels With Structured Mesoporous Walls Alexandre Léonard and Bao-Lian Su Belgium 071 Effect of Inorganic Salt Addition on the Morphology and Texture of Acid-Made Mesoporous Silicas Tie-Zhen Ren, Zhong-Yong Yuan and Bao-Lian Su Belgium 072 Hierarchical Aluminum Oxide-Based Composite Materials with a Uniform Mesoporous- Macroporous Structure Zhong-Yong Yuan, Tie-Zhen Ren and Bao-Lian Su Belgium 073 Preparation of Crack-Free, Transparent, Mesoporous Niobium Oxide Film with Crystalline Structure by Evaporation-Induced Self-Assembly (EISA) Process Kiyotaka Nakajima, Nao Shirokura, Byongjin Lee, Daling Lu, Junko N. Kondo, Michikazu Hara and Kazunari Domen Japan 074 A Highly Sensitive and Selective Fluorescent Nanosensor for Mercury (II) Ions Based on N- Methyl-N-9-(Methylanthracene)-N’-Benzoylthiourea/Mesoporous Silica CMI-1 N. Nivarlet, S. Martinquet and B.-L. Su Belgium 075 The Potential of Highly Structured Mesoporous CMI-1 Materials for the Storage and the Controlled Release of Ibuprofen P. Mariaulle, M. Courcelle and B.-L. Su Belgium 076 Surfactant-Assisted Controllable Synthesis of Mesoporous and Nanostructured Cerium Oxide Materials Aurélien Vantomme, Zhong-Yong Yuan and Bao-Lian Su Belgium 077 New Phenomenon in the Channels of Mesoporous Silicate CMI-1: Photoluminescent Properties, Quantum Size Effect and Two-Photon Absorption of Zno Nanoparticles C. Bouvy; E. Chelnokov; W. Marine and B.-L. Su Belgium, France 078 Synthesis of Hollow Spherical Mesoporous Carbon Materials with Graphitic Framework Yongde Xia, Zhuxian Yang and Robert Mokaya UK 079 Colloidal Crystal Templated Meso&Macro Porous Carbons as High Performance Electrode Materials Isamu Moriguchi, Fimihiro Nakahara, Hirotoshi Yamada and Tetsuichi Kudo Japan 080 Evaluation of Mesostructured Silicas Pores Blocking by Metal Oxide Phase Ensembles Using N2-Adsorption. L.Vradman, M. V. Landau, D. Kantorovich, Y. Koltypin and A. Gedanken Israel 081 Synthesis and Catalytic Application of Tantalum and Silica Pillared Porous Materials from Layered Silicate Ilerite Sun Jin Kim, Min Jo Park, Kwang-Deog Jung and Oh-Shim Joo Korea 082 Novel Synthesis and Characterization of Mesostructured Silica Pearls and Silver-supported Analogs Xiang-Hai Tang, Yu-He Wang and Xin Wen P. R. China 083 Synthesis and Characterization of Nano-sized Anatase-supported SBA-15 Silica with Superacidity Xiang-Hai Tang, Yu-He Wang and Xin Wen P. R. China 084 Formation and Treatment of Large Pore 2-D Hexagonal and 3-D Cubic Mesoporous Silicas Freddy Kleitz, Chia-Min Yang, Cilaîne V. Teixera, Wolfgang Schmidt, Viveka Alfredsson and Mika Lindén Taiwan, Sweden 085 The Prediction of the Reactivity of n-Butyraldehyde over MCM-41 Materials. An In - Situ CIR-FTIR Study Philippe Trens, Nathalie Tanchoux, Pierre-Marie Papineschi and François Fajula France 086 Organic Solvents Adsorption in Mesoporous Materials: A Scaling Effect Approach of Capillary Condensation Processes Philippe Trens, Nathalie Tanchoux, Daniel Maldonado, Francesco Di Renzo and François Fajula France 087 Synthesis of Mesoporous Spheres of MCM-48 Obtained by Pseudomorphic Transformation of Chromatographic Silica Particles Anne Galarneau, Carolina Petitto, Francesco Di Renzo and François Fajula France 088 Investigation of Effect of Particle Size of Ordered Mesoporous Carbon on Catalytic Activity for Direct Methanol Fuel Cell Chanho Pak, Hyung Ik Lee, Ji Man Kim, Dae Jong You, Seol-Ah Lee and Hyuk Chang Korea 089 Melting of Krypton Monolayers Adsorbed On Carbon Nanopores Lucyna Firlej and Bogdan Kuchta France 090 Influence of the Wall Heterogeneity on the Layering Transition in Cylindrical Pores Bogdan Kuchta, Guilaume Maurin and Lucyna Firlej France 091 Synthesis and Characterization of Molecular Sieves Containing Zirconium and Titanium: ET(Zr)S-4 A. Levat, D. Vuon, P. De Luc and A. Nastro ITALY 092 Quantitative Measurement of the Dehydroxylation and Dealumination of Mordenite by 1H, 29 Si, and 27Al MAS and MQMAS NMR Hailong Fei, Tiehong Chen, Kristof Houthoofd and Piet J. Grobet P.R. China, Belgium 093 Toward the Aluminum Cooperation in Dealuminated Modenite and USY: A High Resolution 27 Al MAS and MQ/MAS NMR Study Hailong Fei, Tiehong Chen, Kristof Houthoofd and Piet J. Grobet P.R. China, Belgium 094 Organic Zeolites D. V. Soldatov and J. A. Ripmeester Canada 095 Effect of Catalyst on the Formation and Structure of Bimodal Mesoporous Silica Xiaozhong Wang, Wenhuai Li, Bing Zhong and Kechang Xie P.R. China 096 The Stepwise Formation of Ternary ZnEM [E = S, Se; M = Cd, Hg] Nanomaterials within a Mesoporous Framework Elizabeth A. C. Turner, John F. Corrigan and Yining Huang Canada 097 A High Capacity, Water Tolerant Adsorbent for CO2: Diethanolamine Supported on Pore- Expanded MCM41 Robert Franchi, Peter J.E. Harlick and Abdelhamid Sayari Canada 098 Design of Nanoporous Organic-Inorganic Hybrid Fibers for Highly Selective Removal of Mercury Chunqing Liu, Nathaniel Naismith and James Economy USA 099 Incorporation of Methanol and Ethanol into the Nanostructured Tunnels of Palygorskite W. Kuang and C. Detellier Canada 100 Synthesis and Investigation of Mesoporous Polysiloxane Matrixes Containing Nanoclusters of Some Metals T.F. Gamza, Yu.L. Zub and M.Jaroniec USA 101 Catalytic Activity of Supported Iron Oxide Nanoparticles in the Water Gas Shift Reaction Thiago G. Rosa, Márcia de Souza Ramos, Luiz Carlos Pinheiro Fernandes Júnior, Emília Celma de Oliveita Lima and Maria do Carmo Rangel Brazil, Argentina 102 Adsorption Hysteresis of Pure Fluids in Novel Ordered Micro/Mesoporous Silica Pore Networks M.Thommes, B. Smarsly, P. I. Ravikovitch and A. V. Neimark USA 103 Study of the Sorption and Phase Behavior of Water and Simple Gases in Novel Ordered Mesoporous Materials M.Thommes, H. Huwe, J. Jagiello, J. Dixon, J. Morell and M. Froeba USA, Germany 104 Synthesis and Acidity Modification of Zr-MCM-41 for n-Hexane Isomerization L. F. Chen, L. E. Noreña, J. A. Wang, P. Salsa, J. Navarrete Mexico 105 The Effect of Synthesis Time on Adsorption Properties of FDU-1 Materials Rafal M. Grudzien and Mietek Jaroniec USA 106 Synthesis and Adsorption Properties of FDU-1 Cage-like Silica with Carbon Layers Deposited in Mesopores Ewa B. Celer and Mietek Jaroniec USA 107 Mesoporous Pitch-based Carbons with Bimodal Distribution of Uniform Mesopores Created after Dissolution of Colloidal Silica Spheres and SBA-15 Particles Kamil Gierszal and Mietek Jaroniec USA 108 Periodic Mesoporous Organosilicas with Integrated Multifunctional Spacious Molecular Rings into Silica Framework: Synthesis, Characterization and Application for Heavy Metal Ions Adsorption Oksana Olkhovyk and Mietek Jaroniec USA 109 Optimization of Synthesis Time for SBA-15 Materials Pasquale F. Fulvio and Mietek Jaroniec USA 110 Characterization of Pore Structure of Copolymer-templated Periodic Mesoporous Organosilicas Oksana Olkhovyk, Michal Kruk, Rebecca Sutton and Mietek Jaroniec USA 111 Optimization of Silica/Surfactant Ratio in MCM-41 Synthesis Michal Kruk, Mietek Jaroniec, Hyun June Shin and Ryong Ryoo USA 112 Synthesis of Niobium Molecular Sieves with a New Nb Source and Catalytic Oxidation of Cyclohexene Eliezer Ladeia Gomes and Dilson Cardoso Brazil 113 Selective Introduction of Solid Acid Sites into the Mesopore Surface of Non-acidic USY Zeolite by Aluminum Insertion Hiromichi Shimada, Kosaku Honna, Yasuhiro Araki and Yoichi Nishimura Japan 114 Periodic Mesoporous Organosilicas with Various Organic Functionality and Crystal-Like Pore Wall Structure S. Inagaki, M. P. Kapoor, M. Ohashi and T. Shimada Japan 115 Mesoporous Aluminosilicates from Zeolitic Precursors and TEOS Junlin Zheng, Shangru Zhai, Dongjiang Yang, Dong Wu and Yuhan Sun P. R. China. 116 VOx Loaded Hydrothermally Stable MCM-41 Analogue with Extensive Embedded Voids for Ethylbenzene Dehydrogenation Junlin Zheng, Shangru Zhai, Dongjiang Yang, Dong Wu and Yuhan Sun P. R. China. 117 Hybrid Organic-Inorganic Mesoporous Silicas with Both Hydrothermally Stable Framework and Hydrothermally Stable Functionalities Ningya Yu, Junlin Zheng, Qunli Tang, Dong Wu and Yuhan Sun P. R. China 118 Isopropylation of Naphthalene over Mesostructured Aluminosilicate Nanoparticles with Wormhole Framework Structures Shangru Zhai, Junlin Zheng, Dongjiang Yang, Dong Wu and Yuhan Sun P.R. China 119 Novel Non-Template Route to Mesoporous Silica with Narrowed Pore Size Distribution Dongjiang Yang, Shangru Zhai, Junlin Zheng, Yao Xu, Dong Wu and Yuhan Sun P.R. China 120 Treatment of MSU-S with NaAlO2 solution in the presence of CTAB: Effect of NaAlO2 amount on the structure Shangru Zhai, Junlin Zheng, Dongjiang Yang, Dong Wu and Yuhan Sun P.R. China 121 Famotidine Drug Adsorption on Carboxylic Acid Functionalised Ordered SBA-15 Mesoporous Silica Qunli Tang, Ningya Yu, Zhijie Li, Dong Wu and Yuhan Sun P.R. China 122 Hydrothermal Preparation and Characterization of High Surface Area Perovskite-Type BaTiO3 with Mesoporous Texture Bo Hou, Zhijie Li, Yao Xu, Dong Wu and Yuhan Sun P.R.China 123 Synthesis And Characterization of Exfoliated Poly(Butyacrylate-Co-Methyl Methacrylate)/Clay Via Emulsion Polymerization Zhiyi Zhang, Ning Zhao, Wei Wei, Dong Wu and Yuhan Sun P.R.China 124 SO3H-Functionalized SBA-15 for Esterification of Salicylic Acid with Dimethyl Carbonate Yan Zheng, Xiaowei Su, Xuehong Zhang, Wei Wei and Yuhan Sun P.R.China 125 Synthesis of Mesoporous Zirconia with Enhanced High Thermal and Hydrothermal Stability Yachun Liu, Jiangang Chen and Yuhan Sun P.R.China 126 Optimal Design of Hierarchically Structured Nanoporous Catalysts Marc-Olivier Coppens Netherlands 127 Behavior of NiO and Nio Phases at High Loadings in SBA-15 and SBA-16 Mesoporous Silica Matrices D. Kantorovich, L. Haviv, L. Vradman, M.Kaliya and M. V. Landau Israel 128 Immobilization of Molecular H3PW12O40 Heteropolyacid Catalyst in Alumina-Grafted Mesostructured SBA-15 Silica Matrix P. Madhusudhan Rao, A. Wolfson, M. V. Landau, S.Kababya, S.Vega and M. Herskowitz Israel 129 Effect of Nanoporous ZrO2 Crystal Size on the Surface Sulfur Capacity and Performance of Sulfated ZrO2 as an Acidic Catalytic Material M. V. Landau, L. Titelman, A. M. Shapira-Tchelet, D. Tavor, L. Vradman and A. Wolfson Israel 130 Applications of Skeletal-Structured Biporous Silicate Powders in Adsorption and Catalysis Son-Ki Ihm, Chang-Gun Oh, Younkyoung Baek, Mun-Yong Seong, Ji-Sun Yun and Kyoung-Hun Kim Korea 131 Amine Grafted Mesoporous Silica Supports for Acid Gas Removal from Humid Process Streams Peter J.E. Harlick and Abdelhamid Sayari Canada 132 Metathesis of Linear α-Olefins with MoO3 Supported on MCM-41 Catalyst Hynek Balcar, Pavel Topka, Naděžda Žilková, Joaquin Pérez-Pariente and Jiří Čejka Czech 133 Introduction of Tin into Mesoporous Molecular Sieves for Oxidation of Adamantanone Iveta Nekoksová, Naděžda Žilková and Jiří Čejka Czech 134 Study of the Mechanism of Formation of A Siliceous MSU-X Type Material by Means of Fluorescence Probing and NMR Techniques C. Lesaint, B. Lebeau, C. Marichal and J. Patarin France 135 Synthesis, Characterization and Catalytic Properties of Cobalt and Molybdenum Oxides Supported onto AlMCM-41 Materials with Different Si/Al Ratios Marcelo J. B. Souza, Antonio O. S. Silva, Ana C.S.L.S. Coutinho and Antonio S. Araujo Brazil 136 Hydrodesulphurization of Thiophene over Cobalt and Molybdenum Sulfides Supported On MCM-41 Nanostructured Materials Marcelo J. B. Souza, Antonio O. S. Silva, Anne M. G. Pedrosa, Joana M. F. B. Aquino and Antonio S. Araujo Brazil 137 Fischer-Tropsch Synthesis over Co/SiMCM-41 and Co/SiO2 Materials: The Role of Support at Different Cobalt Loadings Marcelo J. B. Souza, Antonio O. S. Silva, Antonio S. Araujo and Luiz A. M. Pontes Brazil 138 Synthesis and Characterization of Al,Si-SBA-15 Nanostructured Materials with Different Silica-Alumina Ratio Ana C.S.L.S. Coutinho, Antonio S. Araujo, Marcelo J.B. Souza, Antonio O.S. Silva, Geraldo N. Rocha Filho and José R. Zamian. Brazil 139 Soybean Oil Hydrogenation by Ni/MCM-48 Catalysts Patrícia T. S. da Luz, Ana C.S.L.S. Coutinho, Antonio S. Araujo, Paulo R. S. Batista, Miguel Braga, Geraldo N. Rocha Filho and José R. Zamian Brazil 140 Synthesis, Characterization and Luminescent Properties of MCM-41 and AlMCM-41 Mesoporous Materials Containing Tb(III) and Eu(III) Ions Joana M. F. B. Aquino, José Expedito C. da Silva, Antonio S. Araujo, Dulce M. A. Melo Marcelo J. B. Souza and Antonio O. S. Silva Brazil 141 Pollen as a Pore Templating Agent in the Synthesis of Macroporous Silica Terry Nassivera and Christopher Landry USA 142 Degradation of Bis(2-chloroethyl)sulfide with Particulate Mo- and V-doped Mesoporous Silica Adam C. Sorensen, Stephanie Livingston, Christopher R. Ringenbach and Christopher C. Landry USA 143 Strategies for Construction of Porous Silica Particles with Externally Bound Peptides Kai Cheng, Sean Solberg, and Christopher C. Landry USA 144 Synthesis of Highly Ordered Mesoporous Silica with Poly(Vinyl Alcohol) as Template Y. P. Liu, Z. Y. Yuan, J.G. Wang, G. J. Zhang and T.H. Chen P.R. China 145 Synthesis of Hierarchical Structural MCM-41 with High Hydrothermal Stability and Its Application in Environmental Catalysis Su Liu, Lingdong Kong, Xuewu Yan, Quanzhi Li and Adi He P. R. China 146 On the Mechanism of Formation of SBA-1, SBA-2 and SBA-3 as Studied By In Situ XRD N. Baccile, A. Riley, H. Amenistch, S. Tolbert, M. Linden, F. Babonneau USA, Austria, Finland 147 Solid State NMR Investigation of Interactions between Surfactant Molecules and Walls in Mesostructured Organosilicas. N. Baccile, F. Babonneau France 148 Nitrogen Adsorption and Mercury Intrusion in Mesoporous Silicas with Different Pore Connectivities A. Galarneau, B. Lefèvre, H. Cambon, S. Valange, Z. Gabelica, J.P. Bellat and F. Di Renzo France 149 Dynamics and Phase Behaviour of Organic Guests in Mesoporous Materials P.Desjardins, T.Larsen, C.I.Ratcliffe and J.A.Ripmeester. Canada 150 Microporous and Mesoporous Molecular Sieves for Toluene Acylation Jana Klisáková and Jiří Čejka Czech 151 Confinement of Simple Gases inside Open Single-Walled Carbon Nanotubes Zygmunt J. Jakubek and Benoit Simard Canada 152 The Influence of Vanadium Sources on the Catalytic Activity of VMCM-41 P. Selvam and S.E. Dapurkar India 153 Vapor–Phase Photocatalytic Oxidation of VOCs over Novel Uranyl–Anchored MCM-41 Heterogeneous Catalyst K. Vidya, V.S. Kamble, N.M. Gupta and P. Selvam India 154 Pore Size Characterization of Nanoporous Materials and Films from N2, Ar and Organic Vapors Adsorption Peter I. Ravikovitch, Aleksey Vishnyakov, Alexander V. Neimark, Manuela Ribeiro Carrott, Patrúcia Russo and Peter Carrott USA, Portugal 155 Immobilization of Mn(salen) Complex on Aluminum-containing Mesoporous Materials by Microwave Heating for Epoxidation of Styrene Donghong Yin, Jianfu Liu, Yan Zhang, Qiang Gao and Gongxuan Lu China 156 The Solid-state Interaction of ZnCl2 and MCM-41 under Microwave Heating and Used as a Catalyst for High Regioselective Diels-Alder Reaction of Myrcene Jianfu Liu, Donghong Yin, Liangsheng Qin, Dulin Yin and Gongxuan Lu China 157 Production of High Strength Polyethylene Fibers by Ethylene Extrusion Polymerization with Mesoporous Particle Supported Metallocene Catalyst Zhibin Ye and Shiping Zhu Canada 158 The Effect of Carbon in Improving the Stability of Mesoporous Silica Ye Zhang, Ji Man Kim, Wei Wei, Dong Wu and Yuhan Sun P.R. China, Korea 159 Synthesis and Characterization of Tungsten Nitride with High Surface Area Peng Bai and Zi-Feng Yan P.R. China 160 Template Approaches to Various Macroporous Structures Z. Zhou and (George) X.P. Zhao Singapore 161 Morphomogy of Large-pore Periodic Mesoporous Organosilicas X.Y. Bao and (George) X.P. Zhao Singapore 162 Carbonization of Sucrose in the Presence of Zeolite Additive: Control over Pore Structure and Morphology F. Su, L. Lv and (George) X.P. Zhao Singapore 163 Microporous Titanosilicate ETS-10 for Divalent Heavy Metal Removal L. Lv, F. Su and (George) X.P. Zhao Singapore 164 Gold Nano-particles Deposited on Different Mesoporous Alumina for Carbon Monoxide Oxidation at Low Temperature Liangsheng Qin, Jianfu Liu, Donghong Yin P.R. China 165 The Modification of Silica Gel with Amino Groups and Its Catalytic Ability Xuehong Zhang, Bing Chen, Wenyu Zhang, Wei Wei and Yuhan Sun P.R. China 166 Artificial Inorganic Enzymes: Encapsulation of Enzymes on Nanoporous Support Materials B. Paul Zhang, M. T. Janicke, J. A. Bailey and W. Woodruff USA 167 A Novel Mixed Cationic-Nonionic Surfactant Templating Approach For The Synthesis of Mesoporous Niobium Containing Silica - A Promising Epoxidation Catalyst Izabela Nowak and Maria Ziolek Poland 168 Synthesis and Characterization of New Mesostructured Silica HUM-1 Suk Bon Yoon, Jeong Yeon Kim, Jong-Sung Yu, Kamil P. Gierszal and Mietek Jaroniec Korea, USA 169 Catalytic Performance of Noble Metals Supported on Al2O3-Modified MCM-41 for Thiophene Hydrodesulfurization Y. Kanda, Y. Uemichi, T. Kobayashi, L. Andalaluna and M. Sugioka Japan 170 Determining the Spatial Distribution of Al in Various Mesoporous Aluminosilicates E.M. Serwicka, R. Mokaya, J. Połtowicz and W. Jones Poland, UK 171 Proton Transfer Dynamics of 2-Naphthol in NaX Nanoreactors Young-Shin Lee, Hyunung Yu, Oh-Hoon Kwon, and Du-Jeon Jang Korea 172 The Influence of the Preparation Method on the Physico-Chemical and Catalytic Properties of Hydrotalcite Like Compounds with Low Mo-Loading Rodica Zǎvoianu, Ruxandra Bârjega, Octavian Dumitru Pavel and Mihai Alifanti Romania 173 Molecular Designed Vanadia–Titania Supported SBA-15 for the Oxidative Dehydrogenation of Propane and Isobutane Johan S. Paul, Bert F. Sels, Pierre A. Jacobs, Yolanda Segura, Pegie Cool and Etienne F. Vansant Belgium 174 Formation of Nano-Sized Au Particles inside Ti-MCM-48 M. Bandyopadhyay, M.W.E. van den Berg, W.Grünert, and H. Gies Germany 175 Grafting of [CpMo(CO)3]-Na+ Complex by 3,6-Dichloro-Pyridazine Modified Mesoporous MCM-41 and MCM-48 Molecular Sieves Ayyamperumal Sakthivel, Jin Zhao, and Fritz E. Kühn Germany 176 Abatement of Phenol Content of Wastewaters on Mixed (Al-Fe) and (Al-Cu) Pillared Clays Eveline Popovici, Doina Lutic, Claudia-Mihaela Hristodor and Alina-Mihaela Hanu Romania 177 Porosity Analysis of Spin-on Mesoporous Silica Films Chih-Yuan Ting, Hwo-Shuenn Sheu and Ben-Zu Wan Taiwan 178 Synthesis of MCM-41 under Ultrasonic Condition Yongmei Liu, Yingyue qin, Yongkang Lv , Weiren bao, Tao Dou P.R.China 179 A New Method for the Incorporation of Cyclodextrin into Mesostructured Silica Shawn Laurin and Louis Mercier Canada 180 Selective Removal of Sulfur-Containing Compounds from Transportation Fuels Using Rationally-Designed Nanostructured Adsorbents Luc Beaudet, Lacey Pitre and Louis Mercier Canada 181 Pitch-Based Mesoporous Carbons Prepared By Using Colloidal Silica Crystals as Templates Kamil P. Gierszal, Mietek Jaroniec, Jongchul Park and Jong-Sung Yu USA, Korea 182 Synthesis of Mesoporous Solid Acid Catalysts for Improving of Hydrothermal Stability and Acidity Manickam Selvaraj and Tai Gyu Lee Korea 183 Development of Mesoporous solid Acid catalysts in the production of 4-t-Butylcatechol by t- Butylation of 1, 2-dihydroxybenzene Manickam Selvaraj and Tai Gyu Lee Korea 184 Synthesis of Vitamin K3 over Mesoporous Zr-MCM-41 Molecular Sieves Manickam Selvaraj and Tai Gyu Lee Korea 185 Dynamics of Guests in Microporous Coordination Polymers Studied by Solid State NMR and X-ray Analysis Satoshi Horike and Susumu Kitagawa Japan 186 Flexible Coordination Polymers as Novel Porous Materials Susumu Kitagawa, Tapas Maji and Ryotaro Matsuda Japan 187 Physicochemical Properties of FSM-16 modified by F and HPA R. Flores Rodríguez, P. Pérez-Romo, M.L. Guzmán Castillo, H. Armendáriz-Herrera, J. Navarrete- Bolaños, J.A. Montoya de la Fuente and J. J. Fripiat Mexico 188 Ordered Mesoporous Organosilica Films M. Matheron, T. Gacoin, J.-P. Boilot, A. Bourgeois, A. Brunet-Bruneau and J. Rivory France 189 Synthesis of Mesoporous Aluminosilicates via Recrystallisation: Stepwise Alumination of Pure Silica MCM-41 R. Mokaya United Kingdom 190 Conducting Polymer and Carbon Mesoporous Structures by Electrochemical Syntheses Lingchun Li, Vardhan Bajpai, Liangti Qu, and Liming Dai USA 191 Amine-Functionalized Mesoporous Silicas as CO2 Adsorbents Gregory P Knowles, Seamus W Delaney and Alan L Chaffee Australia 192 The Recovery of Rhodium Ions from Mine Effluents using Selective Mesoporous Adsorbents Ali Abughusa, Laxman Amaratunga and Louis Mercier Canada 193 Mesoporous AlPO Supported Heteropolyacid Catalysts in the Ethylation of Ethylbenzene K. Usha Nandhini, Banumathi Arabindoo, M. Palanichamy and V. Murugesan India 194 A Mild, Eco-Friendly and Efficient Zeolite Catalyzed Synthesis of Vibrindole A and Bis(Indolyl)Methanes M. Karthik, M. Palanichamy and V. Murugesan India 195 Thermoanalytical Comparative Studies and Structural Characterization of Essential Oil Extracted of Aniba Canellila (EOAC) Encapsulated in SBA-15 and FDU-1 Silicas Lucildes P. Mercuri, Luis Carlos C. da Silva, Mery dos Santos Filho, Márcia C. A. Fantini, Jivaldo R. Matos, Mietek Jaroniec and Gilberto O. Chierice Brazil, USA 196 DSC and XRD Estimation of Pore Diameter and Pore Wall Thickness of SBA-15 Silica Luis Carlos C. da Silva, Cláudia M. Tortorelli, Marcia C. A. Fantini, Lucildes P. Mercuri, Mietek Jaroniec and Jivaldo do R. Matos Brazil, USA 197 Microwave Synthesis of Mesoporous FDU-1 Silica with Incorporated Humic Acid and its Application for Adsorption of Cd2+ from Aqueous Solutions L. C. Cides da Silva, G. Abate, N. Andrea, M.C.A. Fantini, J. C. Masini, L. P. Mercuri, Mietek Jaroniec and J. R. Matos Brazil, USA 198 Monitoring the Preparation of Spherical Activated Carbon from Copolymer Sulfonated Styrene-Divinylbenzene Resins Sérgio Botelho de Oliveira, Denilson Rabelo, Maria do Carmo Range Brazil 199 Vapour Phase Alkylation of Toluene with Ethyl Acetate over Al-MCM-41 Molecular Sieves K. Shanmugapriya, M. Palanichamy, Banumathi Arabindoo and V. Murugesan India 200 Selective Epimerisation of Sugars using Mesoporous Heterogenized Molybdate Catalysts Bert F. Sels and Pierre Jacobs Belgium 201 Well-Ordered Cubic Mesoporous Carbon with Im3m Symmetry Wanping Guo and (George) X. S. Zhao Singapore 202 The Effect of Nickel on the Textural and Catalytic Properties of Mordenite Lucimar Pacheco Gomes, Alcineia Conceição Oliveira, Saulo de Tarso Figueiredo Grecco, Patrício Reyes, Alberto Albornoz and Maria do Carmo Rangel Brazil, Venezuela 203 Evaluation of MY Zeolites (M= Pt, Pd, Ni) in the Transalkylation of Trimethylbenzene with Benzene Márcia de Souza Ramos, Alcinéia Conceição Oliveira, Débora Correa dos Santos, Saulo de Tarso Figueiredo Grecco, Patrício Reyes and Maria do Carmo Rangel Brazil, Chile 204 Synthesis and Characterization of Mesostructured Alloys with Controlled Compositions Yusuke Yamauchi, Sadasivan Nair Sivakumar, Tokihiko Yokoshima, Toshiyuki Momma, Tetsuya Osaka and Kazuyuki Kuroda Japan 205 Effect of the Solvent Used in the Immobilization of Cobalt(II)-Tetrasulfophthalocyanine Silica-based Si-MCM-41 Nanostructured Material Joana M. F. B. Aquino, Francisco L. de Castro, Glauber J. T. Fernandes, José Alcides S. Martins, Valter J. Fernandes Jr. and Antonio S. Araujo Brazil 206 Adsorption of Lysozyme over Mesoporous Carbons with Various Pore Diameters Ajayan Vinu, M. Miyahara, K. Z. Hossain, T. Nakanishi, and Katsuhiko Ariga Japan 207 Spectroscopic Characterization and Catalytic Performances of Iron Substituted Three Dimensional SBA-1 and KIT-5 Mesoporous Materials Ajayan Vinu, Katsuhiko Ariga and Martin Hartmann Japan, Germany 208 Adsorption of Amino Acids on Mesoporous Molecular Sieves Kazi Zakir Hossain, Ajayan Vinu and Katsuhiko Ariga Japan 209 Acidity and Sorption Properties of Nano-sized Mesoporous Aluminosilicate Materials Wen-Hua Chen, Shing-Jong Huang, Hui-Hsin Ko, An-Ya Lo, Huang-Kuei Lee, Li-Li Wu, Chi-Feng Cheng and Shang-Bin Liu Taiwan 210 Pore Size Characterization of Mesoporous Materials by a Thermodynamic Approach: A Curvature-Dependent Solid Fluid Potential E.A. Ustinov, D.D. Do and M. Jaroniec Australia, Russia, USA 211 Designed Construction of Functional Nano-Structured Inorganic and Hybrid Organic- Inorganic Materials Clément Sanchez, Cédric Boissière and David Grosso France 212 Mesostructured Aluminas with Crystalline Framework Walls Thomas J. Pinnavaia, Zhaorong Zhang and Randall W. Hicks USA 213 Novel Approaches to Adsorption Characterization of Nanoporous Materials Alexander V. Neimark USA 214 Synthesis and Characterization of Nano-sized Mesoporous Aluminosilicate Materials by Microwave Irradiation Chi-Feng Cheng, Hus-Hsuan Cheng, Li-Li Wu and Bo-Wen Cheng Taiwan 215 Synthesis and Characterization of Gallosilicate Mesoporous Molecular Sieves SBA-15 Chi-Feng Cheng and Hsu-Hsuan Cheng Taiwan 216 Preparation of Nanostructured Boron Nitride with Borazine Precursors P. Dibandjo, L. Bois, F. Chassagneux , B. Toury, D. Cornu and P. Miele France 217 In-Situ Studies of the Formation Mechanism of SBA-15 Viveka Alfredsson, Heinz Amenitsch, Katarina Flodström, Mika Lindén, Cilâine V. Teixeira and Håkan Wennerström Sweden, Austria, Finland, Germany 218 Synthesis of Silver Nanoparticles within Ordered Mesoporous Carbon (CMK-3) J. M. Cao, Y. L. Cao, X. Chang, M. B. Zheng, J. S. Liu and H. M. Ji P. R. China 219 Colloidal Crystals as Templates for Zinc Sulphide Inverse Opal via Solvothermal Approach J. M. Cao, X. Chang, M. B. Zheng, H. B. Huang, Y. L. Cao and X. F. Ke P. R. China 220 Facile Solid-state Synthesis of a Lamellar Mesostructured Material J. M. Cao, J. S. Liu, B. Q. Fang, J. Wang, M. B. Zheng and L. J. Pan P. R. China 221 Evaluation of Natural and Modified Romanian Clays for the Removal of Radioactive Isotopes from Liquid Effluents Eveline Popovici, Igor Cretescu, Gabriela Soreanu, Elena Botezatu, Claudia Hristodor, Alina- Mihaela Hanu and Diana Maftei Romania, Canada 222 New Modifications of Layered MCM-36 Molecular Sieve Pillared with Various Mixed Oxides: Facts and Perspectives J. Kornatowski, J.-O. Barth and J.A. Lercher Germany 223 Mesostructured and Mesoporous Pure and Substituted Barium Hexaferrite Phases Eugenia E. Macias, Vadim V. Guliants and Moises A. Carreon Mexico, USA 224 An Ultrafiltration Membrane, Prepared with MSU-Type Mesoporous Silica: Preparation and Specific Filtration Behavior Eric Prouzet, André Larbot, Cédric Boissière and Marco U. Martines France, Brasil 225 Syntheses of Ordered Non-Silica Mesoporous Materials Dongyuan Zhao P.R. China 226 Studies of Anionic Surfactant Templated Mesoporous Structures by Electron Microscopy Alfonso E. Garcia-Bennett, Shunai Che, Keiichi Miyasaka, Yasuhiro Sakamoto, Tetsu Ohsuna, Zheng Liu, and Osamu Terasaki Sweden, P.R. China", "domain": "chemistry", "round": 3} +{"url": "https://cheap5fingers.us/case-study-my-experience-with-6/", "date": "2023-09-23T03:38:20Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233506479.32/warc/CC-MAIN-20230923030601-20230923060601-00404.warc.gz", "language_score": 0.9469260573387146, "token_count": 1310, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__155636458", "lang": "en", "text": "Case Study: My Experience With\nJust How to Capture Carbon and also Transform it Into Electrical power As global warming worsens, even more companies are banking on methods to capture carbon dioxide and turn it right into power. Click here for more info. How to Capture Carbon and also Transform it Into Power As global warming worsens, more companies are banking on means to capture co2 and also turn it into electrical power. Governments are adopting ambitious targets for lowering carbon exhausts, and financiers are ending up being a lot more worried about the risks of climate adjustment. However, while carbon-capture innovations have been around for years, they are still exceptionally expensive and energy extensive. By researching the chemical bonds between carbon dioxide as well as numerous particles, researchers are developing better materials and also approaches to capture carbon. One of these brand-new methods is based on electrochemistry. This technique predicts the strength of a co2 bond. The researchers can after that use this details to identify suitable molecular candidates. For example, they can utilize this method to make a particle that will trap carbon dioxide. This brand-new method can cause cheaper, much more reliable carbon capture technologies. Researchers have actually been creating techniques to transform heat-trapping gases into beneficial substances, such as electrical power and also hydrogen. These techniques may be needed on a large scale to maintain international warming listed below 2.7 degrees Fahrenheit and also ward off the repercussions of environment adjustment. The most popular method of carbon capture is photosynthesis. Plants use sunlight light to take care of carbon dioxide right into biomass, as well as several scientists are researching methods to resemble the procedure. A similar procedure occurs in aquatic atmospheres, where shellfish usage dissolved carbonate to create solid structures. These frameworks are after that deposited safely in rocks throughout the world. Read more here on this page to discover more about this product. Carbon capture is an essential enhance to other procedures for addressing climate modification. It is a vital public service that ought to not depend on profit. As carbon capture modern technologies end up being more affordable, a lot more nations will have the ability to embrace this innovation as well as record more carbon. At some point, carbon capture will certainly end up being cheaper as well as more widespread, making it feasible for even richer nations to capture more CO2. The modern technology can also catch co2 from various other sources, consisting of plants such as a concrete factory or an ammonia plant. Presently, the main emphasis of carbon capture initiatives is in coal-fired nuclear power plant. But this could alter with the execution of new government policies. While there is a small market for carbon sequestration in items, it’s unlikely to reach the range necessary to achieve its full possibility until government plan incentivizes it. Business are increasingly looking at the advantages of using carbon dioxide in oilfields. Occidental, for instance, is a leader in boosted oil recuperation as well as makes use of almost all of the carbon dioxide it draws out from oil tanks. By utilizing this innovation to record carbon, Occidental can additionally benefit from tax incentives and also satisfy corporate environmental targets. Nonetheless, it will certainly also need to resolve governing concerns associated with exhausts. In the future, Occidental is preparing to utilize more of its captured carbon in their oil wells. This innovation can be used at existing and also new coal-fired power plants. However, it is pricey. The procedure requires huge equipment that can lower the efficiency of the turbine. Governments are embracing enthusiastic targets for decreasing carbon discharges, as well as financiers are becoming extra concerned concerning the dangers of climate change. Nonetheless, while carbon-capture modern technologies have been around for years, they are still exceptionally expensive and also power intensive. By studying the chemical bonds between co2 as well as various particles, researchers are developing much better materials and techniques to capture carbon. Among these new techniques is based upon electrochemistry. This method predicts the stamina of a carbon dioxide bond. The scientists can then use this details to determine appropriate molecular prospects. As an example, they can use this technique to make a molecule that will certainly catch CO2. This brand-new method can lead to less expensive, a lot more efficient carbon capture technologies. Researchers have been establishing methods to transform heat-trapping gases into beneficial substances, such as electrical energy and hydrogen. These methods may be needed widespread to keep international warming listed below 2.7 degrees Fahrenheit and repel the consequences of environment change. The most famous approach of carbon capture is photosynthesis. Plants make use of sunlight light to take care of CO2 right into biomass, as well as many researchers are researching ways to mimic the procedure. A similar process takes place in marine environments, where shellfish usage liquified carbonate to create strong structures. These frameworks are after that deposited securely in rocks throughout the world. Carbon capture is a required complement to other procedures for addressing environment modification. It is a vital public service that should not be dependent on revenue. As carbon capture modern technologies end up being more affordable, extra countries will be able to adopt this innovation and capture more carbon. At some point, carbon capture will become cheaper and extra extensive, making it possible for even richer countries to capture even more carbon dioxide. Read more here on this page to discover more about this product. The innovation can likewise capture co2 from other sources, consisting of plants such as a concrete manufacturing facility or an ammonia plant. Presently, the main focus of carbon capture efforts remains in coal-fired power plants. Click for more info on this website. But this could alter with the execution of new government guidelines. While there is a small market for carbon sequestration in products, it’s not likely to reach the range needed to accomplish its complete capacity up until federal government policy incentivizes it. Firms are significantly considering the benefits of utilizing co2 in oilfields. Occidental, for example, is a leader in enhanced oil recovery and utilizes mostly all of the carbon dioxide it extracts from oil storage tanks. By utilizing this technology to record carbon, Occidental can additionally gain from tax motivations and fulfill company environmental targets. Nonetheless, it will additionally need to address governing issues connected to exhausts. In the future, Occidental is planning to use even more of its caught carbon in their oil wells. This modern technology can be made use of at existing and new coal-fired power plants. Nonetheless, it is costly. The process requires large devices that can reduce the efficiency of the generator.", "domain": "chemistry", "round": 3} +{"url": "https://eprints.ncl.ac.uk/72256", "date": "2023-11-28T20:05:46Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679099942.90/warc/CC-MAIN-20231128183116-20231128213116-00665.warc.gz", "language_score": 0.8372840285301208, "token_count": 377, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__303503739", "lang": "en", "text": "Browse by author\nLookup NU author(s): Dr Johanne Bentley,\nProfessor Jane Endicott,\nProfessor Martin NobleORCiD\nFull text for this publication is not currently held within this repository. Alternative links are provided below where available.\nCyclin dependent kinases are a key family of kinases involved in cell cycle regulation and are an attractive target for cancer chemotherapy. The roles of four residues of the cyclin-dependent kinase active site in inhibitor selectivity were investigated by producing cyclin-dependent kinase 2 mutants bearing equivalent cyclin-dependent kinase 4 residues, namely F82H, L83V, H84D, and K89T. Assay of the mutants with a cyclin-dependent kinase 4-selective bisanilinopyrimidine shows that the K89T mutation is primarily responsible for the selectivity of this compound. Use of the cyclin-dependent kinase 2-selective 6-cyclo-hexylmethoxy-2-(4′-sulfamoylanilino)purine (NU6102) shows that K89T has no role in the selectivity, while the remaining three mutations have a cumulative influence. The results indicate that certain residues that are not frequently considered in structure-aided kinase inhibitor design have an important role to play. © 2006 American Chemical Society.\nAuthor(s): Pratt DJ, Bentley J, Jewsbury P, Boyle FT, Endicott JA, Noble MEM\nPublication type: Article\nPublication status: Published\nJournal: Journal of Medicinal Chemistry\nISSN (print): 0022-2623\nISSN (electronic): 1520-4804\nPublisher: American Chemical Society\nPubMed id: 16942020\nAltmetrics provided by Altmetric", "domain": "chemistry", "round": 3} +{"url": "https://www.sesotec.com/na/en-US/resources/expertise/case-studies", "date": "2020-08-05T14:28:34Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-34/segments/1596439735958.84/warc/CC-MAIN-20200805124104-20200805154104-00316.warc.gz", "language_score": 0.9386621713638306, "token_count": 259, "dump": "CC-MAIN-2020-34", "global_id": "webtext-fineweb__CC-MAIN-2020-34__0__138717888", "lang": "en", "text": "Almi, an Austrian company headquartered near Linz, and one of the\nleading manufacturers of quality flavourings and additives for sausage,\nmeat, ham and fish products, uses Sesotec “Hygienic Design” metal\ndetectors throughout their entire production process.\nSeparately purchased recyclate often contains various different polymers as well as metal contaminants such as aluminum, brass, and stainless steel. Learn in our Case Study how Sitraplas has solved this problem.\nThe manual sorting of seeds is time-consuming and causes very high personnel costs. Read in our Case Study how the Quasar contributes to cost savings.\nThe „Alte Gewürzamt“ produces 120 tons spices and spice mixtures per year on 4.000 square meters. The HACCP analysis revealed an increased risk of contamination with metal, stones and glass. An inspection at the outgoing goods was therefore required to meet the quality standards.\nSITRAPLAS GmbH is a producer of high-performance engineering plastic compounds. Unplanned downtime is a nightmare for every company, but especially for continuous production facilities. When metal separators are networked with plastic processing machines, the flow of information between machines can be monitored.", "domain": "chemistry", "round": 3} +{"url": "http://momillo.com/2020/11/06/additives-protected-safe-meals-advocacy-europe/", "date": "2021-04-19T15:31:53Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-17/segments/1618038887646.69/warc/CC-MAIN-20210419142428-20210419172428-00407.warc.gz", "language_score": 0.9502591490745544, "token_count": 510, "dump": "CC-MAIN-2021-17", "global_id": "webtext-fineweb__CC-MAIN-2021-17__0__263640098", "lang": "en", "text": "Our publication, Nutrition Action Healthletter, keeps you up-to-date on food security and nutrition details. Additives are needed to ensure processed meals remains protected and in great condition throughout its journey from factories or industrial kitchens, throughout transportation to warehouses and shops, and lastly to buyers. A color additive is any dye, pigment or substance which when added or applied to a food, drug or cosmetic, or to the human physique, is capable (alone or via reactions with other substances) of imparting color.\nIf new scientific information becomes available suggesting that a food additive is no longer safe, the approval to use the meals additive would be withdrawn. The addition of sugar and vinegar was usually employed to retain the security, flavor, and texture of fruits and vegetables.\nOn the flipside, the meals manufacturing market and regulators say there are excellent reasons to use additives – to avoid meals poisoning or extend a food’s storage life, for example. Final year, the FDA released a report analyzing 91 samples of meals products for PFAS and identified 14 with detectable levels.\nAs soon as a food additive has been discovered to be safe by JECFA, its maximum permitted use level in food is recorded in the Codex Basic Normal for Meals Additives. Increase Taste, Texture and Appearance: Spices, all-natural and artificial flavors, and sweeteners are added to boost the taste of meals.\nWe investigate any details that casts affordable doubt on the security of an additive. When MSG in food is the outcome of hydrolyzed protein, the FDA does not require it to be listed on the packaging. The most common additives to appear on food labels are antioxidants (to avoid deterioration brought on by oxidation), colours, emulsifiers, stabilisers, gelling agents and thickeners, preservatives and sweeteners.\nFor instance, acetic acid is written as E260 on products sold in Europe, but is merely recognized as additive 260 in some nations. Regulatory actions consist of: updating security labels, restricting the use of a drug or device, communicating security data to the public or removing a item from the market.\nThe following table is a list of foods are increasingly becoming “nuked” for your protection. If you do expertise adverse effects, contemplate limiting your intake of processed foods with yeast extract and adding a lot more fresh, complete foods to your diet. These systems have the potential to enhance the function of meals additives, nutraceuticals and dietary supplements, by improving their stability and overall performance.", "domain": "chemistry", "round": 3} +{"url": "https://www.valley-plumbing.com/blog/2023/august/what-are-the-risks-when-using-drain-cleaners-fro/", "date": "2023-09-26T02:53:17Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233510130.53/warc/CC-MAIN-20230926011608-20230926041608-00134.warc.gz", "language_score": 0.9407262206077576, "token_count": 615, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__122957531", "lang": "en", "text": "When faced with a clogged drain, many homeowners turn to store-bought drain cleaners as a quick and easy solution. While these products may seem convenient, they often come with a host of risks that can cause more harm than good to your plumbing system.\nIn this blog post, we will explore the potential dangers associated with using store-bought drain cleaners and provide you with valuable tips to protect your pipes and keep your plumbing system in top shape.\nWhat Are The Risks When Using Drain Cleaners From the Store?\n1. Corrosive Chemicals\nMost store-bought drain cleaners contain highly corrosive chemicals such as sulfuric acid or sodium hydroxide. While these chemicals are effective at dissolving clogs, they can also damage your pipes. Prolonged use of these cleaners can weaken the pipe material, leading to leaks, cracks, or even complete pipe failure. Instead of relying on these harsh chemicals, consider using safer alternatives that are gentle on your plumbing system.\n2. Health Hazards\nStore-bought drain cleaners not only pose a risk to your plumbing system but also to your health and safety. The fumes emitted by these cleaners can be harmful if inhaled, causing respiratory issues or even chemical burns. Additionally, accidental contact with the skin or eyes can result in severe burns or irritation. It is crucial to handle these products with extreme caution and consider safer alternatives to protect yourself and your loved ones.\n3. Environmental Impact\nAside from the potential harm to your plumbing system and health, store-bought drain cleaners can also have a negative impact on the environment. The chemicals present in these products can contaminate water sources and harm aquatic life. By opting for eco-friendly drain cleaning methods, you can help reduce your carbon footprint and contribute to a healthier planet.\n4. Ineffectiveness on Stubborn Clogs\nWhile store-bought drain cleaners may work for minor clogs, they often prove ineffective against more stubborn blockages. Pouring these chemicals down the drain repeatedly without results can lead to wasted time and money. Instead, it is advisable to consult a professional plumber who can accurately diagnose the issue and provide targeted solutions to clear even the toughest clogs.\n5. Damage to Older Plumbing Systems\nIf you have an older plumbing system with aging pipes, the use of store-bought drain cleaners can be particularly risky. The corrosive nature of these chemicals can accelerate the deterioration of already weakened pipes, leading to costly repairs or replacements. It is essential to handle your plumbing system with care and seek professional assistance to ensure its longevity.\nAt Valley Plumbing, we understand the importance of maintaining a healthy plumbing system. Our team of experienced plumbers in Bermuda Dunes, CA, is committed to providing safe and effective solutions for your drain cleaning needs. We utilize advanced techniques and eco-friendly products to protect your pipes and the environment.\nContact us today to schedule a professional drain cleaning service and safeguard your plumbing system from the risks associated with store-bought drain cleaners.", "domain": "chemistry", "round": 3} +{"url": "http://www.genetex.com/ROCK1-antibody-GT261-GTX629971.html", "date": "2017-04-28T00:33:24Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-17/segments/1492917122720.81/warc/CC-MAIN-20170423031202-00288-ip-10-145-167-34.ec2.internal.warc.gz", "language_score": 0.7843165993690491, "token_count": 576, "dump": "CC-MAIN-2017-17", "global_id": "webtext-fineweb__CC-MAIN-2017-17__0__71682808", "lang": "en", "text": "ROCK1 antibody [GT261]\nNot tested in other applications.\n*Optimal dilutions/concentrations should be determined by the researcher.\n|Positive Controls||293T , HeLa , HepG2 , Neuro2A , GL261 , NIH-3T3 , BCL-1 , Raw264.7 , C2C12 , PC-12 , Rat2 , PC-12 (30uM cisplatin for 24hr)|\n(Please refer to the vial label for the specific concentration)|\n|Purification||Affinity purified by Protein G.|\n|Full Name||Rho-associated, coiled-coil containing protein kinase 1|\n|Product Description||Mouse Monoclonal antibody [GT261] to ROCK1 (Rho-associated, coiled-coil containing protein kinase 1)|\n|Background||This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. [provided by RefSeq]|\n|Synonyms||P160ROCK Antibody, Rho-associated, coiled-coil containing protein kinase 1 Antibody, ROCK-I Antibody|\n|Cellular Localization||Cytoplasm , Centrosome , centriole (By similarity) , Golgi apparatus membrane; Peripheral membrane protein |\n|Immunogen||Recombinant protein encompassing a sequence within the N-terminus region of human ROCK1. The exact sequence is proprietary.|\n|Species Reactivity||Human, Mouse, Rat|\n|Predicted Cross Reactivity species Predicted cross-reactivity:|\nPredicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.\nPlease note that we are only able to guarantee products to work in applications and species in which they have been tested.\n|Zebrafish, Rabbit, Chicken, Rhesus Monkey|\n|Predict Reactivity Note||Zebrafish (90%), Rabbit (98%), Chicken (96%), Rhesus Monkey (98%)|", "domain": "chemistry", "round": 3} +{"url": "https://www.ifsc.usp.br/~quantumnano/research/research-at-the-kdtli/", "date": "2023-01-31T14:08:39Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-06/segments/1674764499871.68/warc/CC-MAIN-20230131122916-20230131152916-00698.warc.gz", "language_score": 0.712044894695282, "token_count": 1422, "dump": "CC-MAIN-2023-06", "global_id": "webtext-fineweb__CC-MAIN-2023-06__0__138755900", "lang": "en", "text": "Warning: sizeof(): Parameter must be an array or an object that implements Countable in /home/Grupos/quantumnano/public_html/wp-content/plugins/papercite/papercite.php on line 205\nThe Kapitza-Dirac-Talbot-Lau interferometer (KDTLI) is a unique experimental setup to show quantum interference of large molecules and to measure various properties of the molecules.\nThe experiment is conducted in an international collaboration of researchers. The researchers have different areas of expertise ranging from theoretical and experimental physics to chemistry.\nUnder the supervision of Prof. Markus Arndt Bachelor, Master and PhD students as well as several post-doctoral researchers have been involved in the project.\nThe experiment was started in 2006. However, the research interests have evolved since the early days. The first objective was to show quantum interference with massive molecules. Now, experiments are conducted that go beyond the detection of quantum interference; researchers examine internal properties of molecules by using the quantum interference as a tool for their measurements.\nThe researchers have, so far, investigated the role of electrical properties of the internal structure and conformational changes as well as optical properties and much more.\nEach scientist contributes something new to the project by their individual approach.\n1. Demonstration of the KDTLI and interference of molecules with increasing masses\nS. Eibenberger, S. Gerlich, M. Arndt, M. Mayor and J. Tüxen\nMatter-wave interference with particles selected from a molecular library with masses exceeding 10 000 amu\nPhys. Chem. Chem. Phys., 15, 14696 (2013)\nS. Gerlich, S. Eibenberger, M. Tomandl, S. Nimmrichter, K. Hornberger, P. J. Fagan, J. Tüxen, M. Mayor, and M. Arndt\nQuantum interference of large organic molecules\nNature Communications 2, 263 (2011)\nK. Hornberger, S. Gerlich, H. Ulbricht, L. Hackermüller, S. Nimmrichter, I. V. Goldt, O. Boltalina and M. Arndt\nTheory and experimental verification of Kapitza-Dirac-Talbot-Lau interferometry\nNew J. Phys. 11 (2009) 043032.\nS. Gerlich, L. Hackermüller, K. Hornberger, A. Stibor, H. Ulbricht, F. Goldfarb, T. Savas, M. Müri, M. Mayor and M. Arndt\nA Kapitza-Dirac-Talbot-Lau interferometer for highly polarizable molecules\nNature Physics 3, 711 (2007)\n2. Quantum assisted metrology\nS. Eibenberger, X. Cheng, J.P. Cotter, M. Arndt\nAbsolute absorption cross sections from photon recoil in a matter-wave interferometer\nPhys. Rev. Lett. 112, 250402 (2014)\nS. Eibenberger, S. Gerlich, M. Arndt, J. Tüxen and M. Mayor\nElectric moments in molecule interferometry\nNew J. Phys. 13, 043033 (2011)\nM. Gring, S. Gerlich, S. Eibenberger, S. Nimmrichter, T. Berrada, M. Arndt,H. Ulbricht, K. Hornberger, M. Müri, M. Mayor, M. Boeckmann and N. Doltsinis\nInfluence of conformational molecular dynamics on matter wave interferometry\nPhys. Rev. A 81, 031604(R) (2010)\nJ. Tüxen, S. Gerlich, S. Eibenberger, M. Arndt and M. Mayor\nQuantum interference distinguishes between constitutional isomers\nChem. Comm. 46, 4145 -4147 (2010)\nS. Gerlich, M. Gring, H. Ulbricht, K. Hornberger, J. Tüxen, M. Mayor and M. Arndt\nMatter-Wave Metrology as a Complementary Tool for Mass Spectrometry Angew.\nChem. Int. Ed. 47, 6195 -6198, (2008)\nL. Hackermüller, K. Hornberger, S. Gerlich, M. Gring, H. Ulbricht and M. Arndt\nOptical polarizabilities of large molecules measured in near ‐ field interferometry\nAppl. Phys. B 89 , 469 – 473 (2007)\n3. Review article on quantum interference of molecules and clusters\nK. Hornberger, S. Gerlich, P. Haslinger, S. Nimmrichter and M. Arndt\nColloquium: Quantum interference of clusters and molecules\nRev. Mod. Phys. 84, 157–173 (2012) arXiv:1109.5937v1", "domain": "chemistry", "round": 3} +{"url": "http://battcon.com/Papers/Details/5595", "date": "2022-10-02T10:37:07Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-40/segments/1664030337307.81/warc/CC-MAIN-20221002083954-20221002113954-00231.warc.gz", "language_score": 0.9119160771369934, "token_count": 390, "dump": "CC-MAIN-2022-40", "global_id": "webtext-fineweb__CC-MAIN-2022-40__0__179338678", "lang": "en", "text": "Click on each author name to view the details.\nNiZn batteries are a high voltage aqueous battery system providing an optimal combination of high power and energy while maintaining the highest safety of any battery chemistry available. NiZn is a non-flammable, rechargeable chemistry with an energy density of more than twice that of valve regulated Lead-Acid batteries. It has high-rate capability, can achieve more than 600 deep cycles, and can sit on float charge for extended periods. NiZn has a value proposition that reduces the footprint, weight, and lifecycle costs over Lead-Acid. NiZn also provides a cost improvement over Lithium-Ion by reducing the complexity of the battery management systems (BMS) and controls required, by eliminating the safety concerns associated with thermal runaway. The following are highlights of the NiZn chemistry for data center applications: • NiZn offers better high temperature performance, resulting in reductions of HVAC requirements and costs, thereby increasing the energy efficiency of data centers. • NiZn offers a much lower cost solution throughout the battery life over existing Lead-Acid and Lithium-Ion systems. • NiZn is a drop-in replacement for Lead-Acid utilizing the same racks, cabinets, cabling, inverters, and controls. • NiZn is safe, non-combustible, non-explosive, RoHS compliant and can be fully recycled back into battery grade materials using a cold recycling, energy efficient process. • NiZn offers the highest internal rate of return with a combination of performance, reliability, and value. • The need for a complex BMS is eliminated due to the inherent safety of the NiZn chemistry. • NiZn offers greater energy density and specific energy vs. Lead-Acid, thus reducing handling and other service-related costs, along with increasing building whitespace.", "domain": "chemistry", "round": 3} +{"url": "https://scholarworks.utrgv.edu/pa_fac/553/", "date": "2022-12-07T10:50:44Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-49/segments/1669446711151.22/warc/CC-MAIN-20221207085208-20221207115208-00538.warc.gz", "language_score": 0.871880292892456, "token_count": 372, "dump": "CC-MAIN-2022-49", "global_id": "webtext-fineweb__CC-MAIN-2022-49__0__116504934", "lang": "en", "text": "Two-Temperature Model and Simulation of Induced Electric Field During Combustion Synthesis of Zinc Sulfide in Argon\nA two-temperature (2T) model is employed to analyze an electric field induced during the combustion synthesis of zinc sulfide under the two opposite gravitational conditions of the ascending and descending temperature combustion front motion. This model undertakes situations when the gas is always in a massive abundance, and therefore, the temperatures of the solid and gas phases do not have sufficient time to equilibrate thermally each other during the combustion front motion and generate conditions under which the assumption of one-temperature model of thermal quasi-equilibrium between the phases is no longer valid. The numerical study conducted in a comparison with the experimental results and 1T model shows that 2T model predicts more accurately quantitative values of electric charge density, gas pressure as well as generated voltage during the combustion at both descending and ascending directions of thermal front motions. This demonstrates the key role of non-equilibrium heat transfer for the combustion synthesis, while the temperatures of gas and solid are not equal. The predicted results of characteristic features of induced electric field are in a good agreement with the experimental data.\nMarkov, A.A., Filimonov, I.A. & Martirosyan, K.S. Two-Temperature Model and Simulation of Induced Electric Field During Combustion Synthesis of Zinc Sulfide in Argon. Int J Thermophys 40, 6 (2019). https://doi.org/10.1007/s10765-018-2469-x\nInt J Thermophys", "domain": "chemistry", "round": 3} +{"url": "https://www.bioscience.co.uk/product~69734", "date": "2020-07-07T23:39:21Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-29/segments/1593655895944.36/warc/CC-MAIN-20200707204918-20200707234918-00372.warc.gz", "language_score": 0.8644328713417053, "token_count": 358, "dump": "CC-MAIN-2020-29", "global_id": "webtext-fineweb__CC-MAIN-2020-29__0__254842968", "lang": "en", "text": "Antibody was affinity purified using an epitope specific to ROCK1 immobilized on solid support. The epitope recognized by A300-455A maps to a region between residues 400 and 450 of human Rho-associated, coiled-coil containing protein kinase 1 using the numbering given in Swiss-Prot entry Q13464 (GeneID 6093). Immunoglobulin concentration was determined by extinction coefficient: absorbance at 280 nm of 1.4 equals 1.0 mg of IgG.\np160 ROCK-1, P160ROCK, renal carcinoma antigen NY-REN-35, rho-associated protein kinase 1, Rho-associated, coiled-coil-containing protein kinase 1, Rho-associated, coiled-coil-containing protein kinase I, ROCK-I\nbetween 400 and 450\n2 - 8°C\nDetection of human ROCK1 by western blot of immunoprecipitates. Samples: Whole cell lysate (1 mg/IP; 1/4 of IP loaded/lane) from HeLa cells. Antibodies: Affinity purified rabbit anti-ROCK1 antibodies BL2135, BL2136 (Cat. No. A300-455A), BL2137 (Cat. No. A300-456A) and BL2138 (A300-457A) used at 3 µg/mg lysate for IP. Normal rabbit IgG was used as a control for immunoprecipitation. ROCK1 was blotted with BL2135, BL2137, or BL2138 (each at 1 µg/ml). Detection: Chemiluminescence with exposure times of 10 to 30 seconds.", "domain": "chemistry", "round": 3} +{"url": "https://www.dgatinhibitor.com/2023/10/09/12578/", "date": "2024-04-25T15:02:07Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712297295329.99/warc/CC-MAIN-20240425130216-20240425160216-00401.warc.gz", "language_score": 0.9558207988739014, "token_count": 850, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__176578401", "lang": "en", "text": "E microscope. For fluorescence monitoring, the detection point was positioned either next to reservoir 2 (Figure 1a and 1b), or directly around the monolith. The collected CCD pictures were analyzed making use of V++ Precision Digital Imaging application (Auckland, New Zealand). Photomultiplier tube (PMT) detection was also utilized, in which the detection point was positioned next to reservoir two. Collected fluorescence went via a D600/60 band-pass filter (Chroma, Rockingham, VT) and was detected at a Hamamatsu PMT (HC120-05, Bridgewater, NJ); out-of-focus light was blocked by a 1000 m diameter pinhole. The PMT voltage output was processed by a preamplifier (SR-560, Stanford Research Systems, Sunnyvale, CA) and an analog-to-digital converter (PCI 6035E, National Instruments, Austin, TX) and was recorded by LabView application running on a Dell computer.NIH-PA Author GLUT4 Inhibitor Molecular Weight Manuscript NIH-PA Author Manuscript NIH-PA Author Manuscript3. Benefits and Discussion3.1 Optimization of monoliths Thermally bonded COC devices with monoliths formed from different monomers have been ready. COC was selected as the substrate material due to the fact of its stability in widespread organic solvents, which include ACN made use of in this study for sample elution. Poly(methyl methacrylate) dissolves in ACN, though poly(dimethylsiloxane) demands added surface modification as well as swells in solvents [42?4]. Additives like UV absorbers utilized to stabilize polymers which include COC may perhaps impact the UV dose inside the channel Through monolith polymerization; nevertheless, we had been generally able to have adequate radiation into the channels to type monoliths within the 12?5 min reaction time. For the duration of monolith polymerization Tween 20 was added as a surfactant to increase the by means of pore size by affecting phase separationAnal Bioanal Chem. Author manuscript; readily available in PMC 2016 January 01.Yang et al.Pagethrough emulsion. Surfactant content was chosen to be 30 , ATR Activator Accession considering the fact that monoliths prepared with higher surfactant content material produced bubbles when voltage was applied, which hindered the flow of remedy within the microchannel . A 55 total porogen content was chosen considering the fact that monolith rigidity became too low if higher porogen content was utilised, as reported within a preceding study by Pagaduan et al. . In this function, monoliths were prepared from 4 unique varieties of monomers (MMA, BMA, OMA and LMA). Figure 3 shows SEM images of monoliths prepared using the distinct monomers. For monoliths ready from MMA (Figure 3a), evenly packed nodules with diameters of 500?000 nm have been observed. Through pores formed by the voids amongst these nodules have been inside the exact same size range. For monoliths prepared from the other 3 monomers, nodules with a great deal smaller sized sizes had been observed (Figure 3b-d), which resulted in much more surface area and therefore much more binding capacity. For BMA monoliths (Figure 3b), via pores with diameters of many a huge selection of nanometers were observed. Uniform material was discovered only inside the central section of your monolith, although the majority on the channel contained discrete porous clusters of unique lengths. This really is constant using the observations of Ramsey and Collins , which have been explained by localized fluid flow during in situ photopolymerization. For monoliths ready from OMA and LMA (Figure 3c-d), different sizes of via pores formed by agglomerates of nodules with dimensions of 100 nm had been observed, which is favorable due to the fact irregular pores improve convective transport as liquids flow by means of the monolith . Upon ap.", "domain": "chemistry", "round": 3} +{"url": "https://www.americangilsonite.com/end-markets/oil-gas/cementing/", "date": "2024-04-23T12:09:29Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712296818474.95/warc/CC-MAIN-20240423095619-20240423125619-00733.warc.gz", "language_score": 0.8704096078872681, "token_count": 321, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__94107890", "lang": "en", "text": "For more than 50 years, the industry has depended on Gilsonite® uintaite as a lost circulation material and a critical component for primary cementing operations in some of the world’s toughest drilling environments.\nAdding Gilsonite® during cementing operations enhances the characteristics that are critical to effectively cementing the casing, isolating hydrocarbon formations and preventing annular gas flow.\nWith its unique physical and chemical properties, Gilsonite® uintaite provides a range of important benefits in slurry and set cement that are unmatched by any other single additive.\nCement slurry benefits\n- Increases yield\n- Reduces slurry weight\n- Controls free water\n- Lowers slurry water ratio\n- Promotes favorable rheologies resulting in lower ECDs\n- Prevents lost circulation\n- Scours wellbore/enhances mud removal\nSet cement benefits\n- Maintains compressive strength, unlike coal or fly ash\n- Increases flexibility\n- Reduces cracking\n- Heals microfissures\n- Reduces permeability\n- Strengthens bond to the formation and the casing\n- Reduces environmental risk\n- Assures zonal isolation\nGilsonite® eliminates the problems of free water\nBy controlling free water, Gilsonite® uintaite helps stabilize slurry and eliminates the need for – and cost of – additional free-water-control agents. As a lost circulation material, it also improves zonal isolation by preventing water channeling on the upper side of the wellbore.", "domain": "chemistry", "round": 3} +{"url": "https://www.dojindo.com/products/W201/", "date": "2023-06-10T14:33:37Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-23/segments/1685224657720.82/warc/CC-MAIN-20230610131939-20230610161939-00412.warc.gz", "language_score": 0.7203425168991089, "token_count": 1491, "dump": "CC-MAIN-2023-23", "global_id": "webtext-fineweb__CC-MAIN-2023-23__0__87872133", "lang": "en", "text": "Reductive Chromogenic Dye\nProduct codeW201 WST-1\nChemical name2-(4-Iodophenyl)-3-(4-nitrophenyl)-5-(2,4-disulfophenyl)-2H-tetrazolium, monosodium salt\n|Unit size||Price||Item Code|\nProduct Description of WSTs\nWater-soluble tetrazolium salts (WSTs) were developed by introducing positive or negative charges and hydroxy groups to the phenyl ring of the tetrazolium salt. Positive charges, such as trialkylammonio groups, improve the water-solubility of the formazan dye. However, a large cation is easily precipitated out with organic anions such as carboxylate or phosphate. Although a hydroxy group also improved the\nwater solubility of the tetrazolium salt, the corresponding formazan dye was not sufficiently water-soluble. Dojindo’s WSTs have sulfonate groups added directly or indirectly to the phenyl ring to improve water-solubility. Dojindo also offers several newly developed phenylazotype tetrazolium salts, which are easily reduced with NADH or other reducing agents to give orange or purple formazan dyes. Due to the phenylazo group, the color changes with heavy metal ion. Since the water solubility of Dojindo’s WSTs is high, 10 mM to 100 mM solutions can be prepared.\nFig 2 Absorption Spectra of WST Formazan Dyes\n1) M. Ishiyama, M. Shiga, K. Sakamoto, M. Mizoguchi and Pin-Gang He, \"A New Sulfonated Tetrazolium Salt That produces a Highly Water-soluble Formazan Dye\", Chem. Pharm. Bull., 1993, 41, 1118.\n2) T. Yano, K. Teruya, S. Shirahata, J. Watanabe, K. Osada, H. Tachibana, H. Ohashi, Eun-Ho Kim and H. Murakami, \"Ras Oncogene Enhances the Production of a Recombinant Protein Regulated by the Cytomegalovirus Promoter in BHK-21 Cells\", Cytotechnology, 1994, 16, 167.\n3) K. Teruya, T. Yano, S. Shirahata, J. Watanabe, K. Osada, H. Ohashi, H. Tachibana, Eun-Ho Kim and H. Murakami, \"Ras Amplification in BHK-21 Cells Produces a Host Cell Line for Further Rapid Establishment of Recombiant Protein Hyper-producing Cell Lines\", Biosci. Biotech. Biochem., 1995, 59, 341.\n4) M. Ishiyama, K. Sasamoto, M. Shiga, Y. Ohkura and K. Ueno, \"Novel Disulfonated Tetrazolium Salt That can be Reduced to a Water-soluble Formazan and Its Application to the Assay of Lactate Dehydrogenase\", Analyst, 1995, 120, 113.\n5) M. Ishiyama, H. Tominaga, M. Shiga, K. Sasamoto, Y. Ohkura, K. Ueno and M. Watanabe, \"Novel Cell Proliferation and Cytotoxicity Assays Using a Tetrazolium Salt That Produces a Water-soluble Formazan Dye\", In Vitro Toxicology, 1995, 8, 187.\n6) S. Q. Liu, K. Saijo, T. Todoroki and T. Ohno, \"Induction of Human Autologous Cytotoxic T Lymphocytes on Formalin-Fixed and Paraffin-Embedded Tumour Sections\", Nature Med., 1995, 1(3), 267.\n7) T. Takenouchi and E. Munekata, \"Trophic Effects of Substance P and β-Amyloid Peptide on Dibutyryl Cyclic AMP-Differentiated Human Leukemic (HL-60) Cells\", Life Sci., 1995, 56, 479.\n8) T. Iwaki, A. Iwaki, Y. Fukumaki and J. Tateishi, \"β-Crystallin in C6 Glioma Cells Supports their Survival in Elevated Extracellular K+: the Implication of a Protective Role of β-Crystallin Accumulation in Reactive Glia\", Brain Res., 1995, 673, 47.\n9) M. Ishiyama, H. Tominaga, M. Shiga, K. Sasamoto, Y. Ohkura and K. Ueno, \"A Combined Assay of Cell Viability and vitro Cytotoxycity with a Highly Water-soluble Tetrazolium Salt, Neutral Red and Crystal Violet\", Biol. Pharm. Bul., 1996, 19, 1518.\n10) T. Mosmann, \"Rapid Colorimetric Assay for Cellular Growth and Survival: Application to Proliferation and Cytotoxicity Assays\", J. Immunol. Methods, 1983, 65, 55.\n11) A. H. Cory, T. C. Owen, J. A. Barltrop and J. G. Cory, \"Use of an Aqueous Soluble Tetrazolium/Formazan Assay for Cell Growth Assays in Culture\", Cancer Commun., 1991, 3, 207.\n12) N. W. Roehm, G. H. Rodgers, S. M. Hatfield and A. L. Glasebrook, \"An Improved Colorimetric Assay for Cell Proliferation and Viability Utilizing the Tetrazolium Salt XTT\", J. Immunol. Methods, 1991, 142, 257.\nHandling and storage condition\n|Appearance：||Pale yellow to yellowish brown powder|\n|Solubility in water：||To pass test (clear, pale yellow to yellowish brown)|\n|Molar absorptivity：||≧ 21,600 (around 244 nm)|\n|Water content：||≦ 6.0 %|\n|Sensitivity：||To pass test|\n|Thin Layer Chromatogram：||To pass test|", "domain": "chemistry", "round": 3} +{"url": "https://www.mitchsgardening.com.au/services/soil-testing/", "date": "2019-09-21T03:26:20Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-39/segments/1568514574182.31/warc/CC-MAIN-20190921022342-20190921044342-00396.warc.gz", "language_score": 0.8654879927635193, "token_count": 314, "dump": "CC-MAIN-2019-39", "global_id": "webtext-fineweb__CC-MAIN-2019-39__0__118176178", "lang": "en", "text": "Soil testing and analysis to help your Perth garden thrive!\nCall us on 0425 057 892 to discuss how we can help sort those plant and lawn deficiencies.\nOur soil testing by agronomists\n- Onsite soil sampling\n- Comprehensive soil testing in our labs\n- Detailed analysis of results\n- Fertilising recommendations\n- Specific garden advice tailored to your test results\n- Custom fertiliser blends\n- Tailored treatments for your garden\nHelp from us looks like:\n- Comprehensive Soil Analysis – provides you with a detailed analysis of your soil including pH, nitrogen, organic matter %, sulphur, potassium, phosphorus, boron, copper, zinc, manganese, iron and exchangeable cations calcium, magnesium, sodium, potassium and aluminium.\n- Detailed Soil Report – helps you understand your test results, and provides you with clear solutions for balancing the nutrition and ecology of your soil for optimum plant growth.\n- Tailored Fertilising Program – ensures your garden gets exactly what it needs to thrive. You won’t waste money on fertilisers your garden doesn’t need and you’ll balance your soil’s nutrients for superior plant growth.\n- Garden Report – you’ll know exactly where your garden is at, with a comprehensive identification and analysis of your gardens pests, diseases and weeds, with clear solutions to solve them.\nCall the office on 0425 057 892 to discuss how we can help or contact via the below", "domain": "chemistry", "round": 3} +{"url": "https://ownersmanuals2.com/honda/vt1300cx-a-2018-owners-manual-75009/page-52", "date": "2020-02-19T09:44:52Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-10/segments/1581875144111.17/warc/CC-MAIN-20200219092153-20200219122153-00087.warc.gz", "language_score": 0.8683934807777405, "token_count": 317, "dump": "CC-MAIN-2020-10", "global_id": "webtext-fineweb__CC-MAIN-2020-10__0__177362493", "lang": "en", "text": "Your motorcycle has a maintenance-free type\nbattery. You do not have to check the battery\nelectrolyte level or add distilled water. Clean the\nbattery terminals if they become dirty or\nDo not remove the battery cap seals. There is\nno need to remove the cap when charging.\nAn improperly disposed of battery can be\nharmful to the environment and human health.\nAlways confirm local regulations for proper\nbattery disposal instruction.\nWhat to do in an emergency\nIf any of the following occur, immediately see\nElectrolyte splashes into your eyes:\nu Wash your eyes repeatedly with cool\nwater for at least 15 minutes. Using water\nunder pressure can damage your eyes.\n● Electrolyte splashes onto your skin:\nu Remove affected clothing and wash your\nskin thoroughly using water.\n● Electrolyte splashes into your mouth:\nu Rinse mouth thoroughly with water, and\ndo not swallow.\nThe battery gives off explosive\nhydrogen gas during normal operation.\nA spark or flame can cause the battery\nto explode with enough force to kill or\nseriously hurt you.\nWear protective clothing and a face\nshield, or have a skilled mechanic do\nthe battery servicing.\nWARNING: Battery posts, terminals, and related\naccessories contain lead and lead compounds.\nWash your hands after handling.\n20170726153758_31MFR6800_enu_BOOK Page 51 Wednesday, July 26 2017 15:43:25 JST", "domain": "chemistry", "round": 3} +{"url": "https://www.scientific.net/AST.70.47", "date": "2017-10-20T04:16:06Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-43/segments/1508187823630.63/warc/CC-MAIN-20171020025810-20171020045810-00596.warc.gz", "language_score": 0.8331562876701355, "token_count": 343, "dump": "CC-MAIN-2017-43", "global_id": "webtext-fineweb__CC-MAIN-2017-43__0__234554864", "lang": "en", "text": "Mechanical Behaviour of MgO-CaZrO3-Based Refractories for Cement Kilns\nThe mechanical behaviour of ceramic refractories formulated in the MgO-CaO-SiO2- ZrO2 system is analysed in terms of the room temperature Young´s modulus, the modulus of rupture and the work of fracture at 25 and 1100°C. The materials have been designed taking into account the phase equilibrium relationships to obtain MgO-CaZrO3-Ca2SiO4-Ca3Mg(SiO4)2 or MgO-CaZrO3-Ca3Mg(SiO4)2-c-ZrO2 as final crystalline phases. Different relationships between the proportion and sizes of the fines and the aggregates have been explored. The microstructure of the materials has been characterised in terms of density, crystalline phases and phase distribution and morphology. A combination of X-Ray diffraction (XRD) analyses and Reflected Light Optical Microscopy (RLOM) has been used. The relationships between the obtained phases and microstructures and the grain size distributions of the used raw materials have been established. The relationships between the mineralogical composition and the obtained microstructure and the mechanical behaviour are discussed.\nPietro VINCENZINI and James P. BENNETT\nC. Baudín et al., \"Mechanical Behaviour of MgO-CaZrO3-Based Refractories for Cement Kilns\", Advances in Science and Technology, Vol. 70, pp. 47-52, 2010", "domain": "chemistry", "round": 3} +{"url": "https://mse.engr.uconn.edu/jasna-jankovic", "date": "2019-09-19T10:43:34Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-39/segments/1568514573476.67/warc/CC-MAIN-20190919101533-20190919123533-00308.warc.gz", "language_score": 0.6537677049636841, "token_count": 640, "dump": "CC-MAIN-2019-39", "global_id": "webtext-fineweb__CC-MAIN-2019-39__0__112808742", "lang": "en", "text": "Department of Materials Science & Engineering\n97 North Eagleville Road, Unit 3136\nStorrs, CT 06269-3136\n|2017||Technology Demonstration Gate AFCC Recognitions|\n|2013||AFCC Major Contributor|\n|2011-2013||Natural Science and Engineering Research Council (NSERC) IRDF|\n|2007-2009||Natural Science and Engineering Research Council (NSERC) CGS-D|\n|2006||Public Service Award of Excellence (employment equity and diversity)|\n|2006||Outstanding Achievement Award (employment equity and diversity)|\n|2003-2004||Natural Science and Engineering Research Council (NSERC) PGS-A|\n|1994-1996||Petroleum Refinery Pancevo|\n|1990-1995||Republic of Serbia Scholarship for Undergraduate Students|\nJ. Jankovic, S. Zhang, A. Putz, M. S. Saha, D. Susac, Multi-scale imaging and transport modeling for fuel cell electrodes, (invited) submitted to Journal of Materials Research, (2018), JMR 2018-0613.\nS. Chan, J. Jankovic, D. Susac, M. S. Saha, M. Tam, H. Yang, F. Ko, Electrospun carbon nanofibers for PEM fuel cells: Fabrication and optimization, J. Mater. Sci. 53:11633–11647. (2018).\nS. Chan, J. Jankovic, D. Susac, M. S. Saha, M. Tam, H. Yang, F. Ko, Electrospun carbon nanofiber catalyst layers for polymer electrolyte membrane fuel cells: structure and performance, Journal of Power Sources, 392, 239-250 (2018).\nA. Kneer, J. Jankovic, D. Susac, A. Putz, N. Wagner, M. Sabharwal, M. Secanell, Correlation of Changes in Electrochemical and Structural Parameters due to Voltage Cycling Induced Degradation in PEM Fuel Cells, Journal of The Electrochemical Society, 165 (6) F3241-F3250 (2018).\nSabharwal, A. M. V. Putz, D. Susac, J. Jankovic, and M. Secanell, Improving FIB-SEM reconstructions by using epoxy resin embedding, 232nd ECS Meeting Transactions (2017).\nG. A. Melo, A. P. Hitchcock, V. Berejnov, J. Jankovic, J. Stumper, D. Susac, Quantitative mapping of PFSA ionomer in catalyst layers by electron and X-ray spectromicroscopy, 232nd ECS Meeting Transactions (2017).\nSabharwal, L. M. Pant, A. Putz, D. Susac, J. Jankovic, M. Secanell, Analysis of catalyst layer microstructures: From imaging to performance, Fuel Cells 16 (2016) 734-753.", "domain": "chemistry", "round": 3} +{"url": "http://www.abcam.com/FGF10-antibody-ab90207.html", "date": "2013-12-09T02:21:37Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2013-48/segments/1386163848048/warc/CC-MAIN-20131204133048-00086-ip-10-33-133-15.ec2.internal.warc.gz", "language_score": 0.819920539855957, "token_count": 1049, "dump": "CC-MAIN-2013-48", "global_id": "webtext-fineweb__CC-MAIN-2013-48__0__129363124", "lang": "en", "text": "Anti-FGF10 antibody (ab90207)\n- Product nameAnti-FGF10 antibodySee all FGF10 primary antibodies ...\n- DescriptionGoat polyclonal to FGF10\n- Tested applicationsWB, Indirect ELISA, Sandwich ELISA more details\n- Species reactivityReacts with: Recombinant Fragment\nPredicted to work with: Human\nHighly pure (>98%) recombinant hFGF-10\n- Storage instructionsStore at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze / thaw cycles.\n- Storage bufferPreservative: None\nConstituents: PBS, pH 7.2\n- Concentration information loading...\n- PurityImmunogen affinity purified\n- Clonality Polyclonal\n- Research Areas\nOur Abpromise guarantee covers the use of ab90207 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\n|WB||WB: Use a concentration of 0.1 - 0.2 µg/ml. Predicted molecular weight: 23 kDa. To detect hFGF-10 by Western Blot analysis this antibody can be used at a concentration of 0.1- 0.2 µg/ml. Used in conjunction with compatible secondary reagents the detection limit for recombinant hFGF-10 is 1.5-3.0 ng/lane, under either reducing or non-reducing conditions.|\n|Indirect ELISA||I-ELISA: Use a concentration of 0.5 - 2 µg/ml. To detect hFGF-10 by indirect ELISA (using 100 µl/well antibody solution) a concentration of 0.5 - 2.0 µg/ml of this antibody is required. This antigen affinity purified antibody, in conjunction with compatible secondary reagents, allows the detection of at least 0.2 - 0.4 ng/well of recombinant hFGF-10.|\n|Sandwich ELISA||sELISA: Use a concentration of 5 µg/ml. Can be paired for Sandwich ELISA with Rabbit polyclonal to FGF10 (ab71794) and Goat polyclonal to FGF10 (Biotin) (ab83439). Can be used as Capture antibody when paired with ab83439. For sandwich ELISA, use this antibody as Capture at 5µg/ml with ab71794 as Detection.|\n- FunctionCould be a growth factor active in the process of wound healing. Acts as a mitogen in the lung. May act in a manner similar to FGF-7.\n- Involvement in diseaseDefects in FGF10 are the cause of autosomal dominant aplasia of lacrimal and salivary glands (ALSG) [MIM:180920]. ALSG has variable expressivity, and affected individuals may have aplasia or hypoplasia of the lacrimal, parotid, submandibular and sublingual glands and absence of the lacrimal puncta. The disorder is characterized by irritable eyes, recurrent eye infections, epiphora (constant tearing) and xerostomia (dryness of the mouth), which increases the risk of dental erosion, dental caries, periodontal disease and oral infections.\nDefects in FGF10 are a cause of lacrimo-auriculo-dento-digital syndrome (LADDS) [MIM:149730]; also known as Levy-Hollister syndrome. LADDS is a form of ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. LADDS is an autosomal dominant syndrome characterized by aplastic/hypoplastic lacrimal and salivary glands and ducts, cup-shaped ears, hearing loss, hypodontia and enamel hypoplasia, and distal limb segments anomalies. In addition to these cardinal features, facial dysmorphism, malformations of the kidney and respiratory system and abnormal genitalia have been reported. Craniosynostosis and severe syndactyly are not observed.\n- Sequence similaritiesBelongs to the heparin-binding growth factors family.\n- Cellular localizationSecreted.\n- BB213776 antibody\n- fd11d03 antibody\n- FGF 10 antibody\n- FGF-10 antibody\n- FGF10 antibody\n- FGF10_HUMAN antibody\n- Fibroblast growth factor 10 antibody\n- Keratinocyte growth factor 2 antibody\n- KGF 2 antibody\n- wu:fd11d03 antibody\n- zgc:109774 antibody\nAnti-FGF10 antibody images\nReferences for Anti-FGF10 antibody (ab90207)\nab90207 has not yet been referenced specifically in any publications.", "domain": "chemistry", "round": 3} +{"url": "https://healthfully.com/list-acid-foods-6301085.html", "date": "2018-05-23T12:37:05Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-22/segments/1526794865651.2/warc/CC-MAIN-20180523121803-20180523141803-00321.warc.gz", "language_score": 0.9722617864608765, "token_count": 354, "dump": "CC-MAIN-2018-22", "global_id": "webtext-fineweb__CC-MAIN-2018-22__0__90679976", "lang": "en", "text": "Alkaline and acid balance in the body plays a major role when it comes to the overall health of a person. If acid levels become to high, a person has ailments that affect the digestive system or has recently had oral surgery, then acidic foods should be avoided until the problem is rectified.\nMilk has no acid in it as it is a base food and often temporarily settles a large amount of acid production in the stomach. It is a base which neutralizes acid in the digestive system and keeps it from adversely effecting the body when it is released. Milk should be drunk regularly throughout the day in small doses for someone with serious acid reflux. Skim milk is best, as it is the healthiest milk to consume regularly.\nRice, Breads and Pasta\nRice, breads and pasta are non-acidic foods which soak up large amounts of acid in the digestive track and when broken down raise the alkalinity of the body in general. These foods and others which are high in carbohydrates are recommended for people who have serious acidic reflux disease and need a constant remedy when they are eating outside of taking medication. These foods should be consumed in small meals throughout the day in those situations.\nLettuce is an acid-free food which helps to pacify the stomach and allows a large amount of alkalinity back into the body in a natural way. Lettuce can be eaten in sandwiches or on salads, as long as there are no vegetables like onions or garlic which have moderate to high levels of acidity on them. Dressing is also important to pay attention to with lettuce and salads, as the lettuce is fine but the dressing could be very high in vinegar, which has a high acid content.", "domain": "chemistry", "round": 3} +{"url": "http://www.abcam.cn/trichomonas-vaginalis-antibody-b984m-ab105879.html", "date": "2017-05-25T14:44:54Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-22/segments/1495463608084.63/warc/CC-MAIN-20170525140724-20170525160724-00584.warc.gz", "language_score": 0.6571363210678101, "token_count": 313, "dump": "CC-MAIN-2017-22", "global_id": "webtext-fineweb__CC-MAIN-2017-22__0__92397309", "lang": "en", "text": "- 存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.\n- 存储溶液Preservative: 0.1% Sodium Azide\nConstituents: 0.01M PBS, pH 7.2\nConcentration information loading...\n- 纯度Protein A purified\n- 纯化说明ab105879 is >90% pure\nOur Abpromise guarantee covers the use of\nin the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\n应用说明Is unsuitable for ELISA.\n||Use at an assay dependent dilution.\n- 相关性Trichomonas vaginalis is a protozoa which causes inflammation of the vaginal canal. It is considered to be a sexually transmitted disease.\n- T vaginalis antibody\n- TV antibody\nAnti-Trichomonas vaginalis antibody [B984M] (ab105879)参考文献\nhas not yet been referenced specifically in any publications.\nPlease note: All products are \"FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE\"", "domain": "chemistry", "round": 3} +{"url": "https://www.moluna.de/buch/4190419-structure+and+function+of+invertebrate+oxygen+carriers/", "date": "2018-05-20T10:13:25Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-22/segments/1526794863277.18/warc/CC-MAIN-20180520092830-20180520112830-00157.warc.gz", "language_score": 0.6715447306632996, "token_count": 1241, "dump": "CC-MAIN-2018-22", "global_id": "webtext-fineweb__CC-MAIN-2018-22__0__102546873", "lang": "en", "text": "I. Quaternary and Three-Dimensional Structure.- 1 The Architecture of 4x6-meric Arachnid Hemocyanin.- 2 Static and Kinetic Studies on the Dissociation of Limulus polyphemus Hemocyanin with Solution X-Ray Scattering.- 3 The Di-decameric Hemocyanin of the Atlantic Murex Snail, Muricanthus fulvescens (Sowerby).- 4 Scanning Transmission Electron Microscopy (STEM) Studies of Molluscan Hemocyanins.- 5 Spectroscopic Analysis of Temperature-Induced Unfolding of the Hemocyanin from the Tarantula Eurypelma californicum.- 6 Subunit Structure of the Hemocyanin from the Arthropod OvaUpes catharus.- 7 Crosslinking with Bifunctional Reagents and its Application to the Determination of the Quaternary Structures of Invertebrate Extracellular Hemoglobins.- 8 Arthropod (Cyamus scammoni, Amphipoda) Hemoglobin Structure and Function.- 9 The Principal Subunit of Earthworm Hemoglobin is a Dodecamer of Heme-Containing Chains.- 10 Heterogeneity of the Products of Dissociation of Lumbricus terrestris Hemoglobin at Alkaline pH.- 11 Studies on the Dissociation of Eudistylia vancouverii Chlorocruorin.- II. Structure and Function.- 12 Nested Allostery of Arthropod Hemocyanins.- 13 Subunits and Cooperativity of Procambarus clarki Hemocyanin.- 14 Analysis of Oxygen Equilibrium Using the Adair Model for the Hemocyanin of Limulus polyphemus and the Hemoglobin of Eisema foetida.- 15 Structural and Functional Characterization of the Hemoglobin from Lumbricus terrestris.- 16 Interaction of Divalent Metal Ions with the Hemoglobin of Glossoscolex paulistus: an EPR Study.- 17 Oxidation of the Extracellular Hemoglobin of Glossoscolex paulistus.- 18 Kinetic Evidences for Slow Structural Changes in the Chlorocruorin from Spirographis spallanzanii.- 19 Scapharca inaequivalvis Hemoglobins: Novel Cooperative Assemblies of Globin Chains.- 20 High and Low Spin Forms of Oxidized Dimeric Scapharca inaequivalvis Hemoglobin.- 21 Aplysia Myoglobin: Involvement of Two Kinds of Carboxyl Groups in the Autoxidation Reaction.- 22 Aplysia limacina Myoglobin: Molecular Bases for Ligand Binding.- 23 Biophysical Characterization of Constituents of the Glycera dibranchiata Oxygen Transport and Utilization System: Erythrocytes and Monomer Hemoglobins.- 24 Oxygen Equilibrium Characteristics of Hemerythrins from the Brachiopod, Lingula unguis, and the Sipunculid, Siphonosoma cumanense.- 25 The Dynamics of Dioxygen Binding to Hemerythrin.- 26 Distribution of Hemerythrin's Conformational Substates from Kinetic Investigations at Low Temperature.- III. Amino Acid and cDNA Sequences.- 27 Translation of the cDNA Sequence for the Polymeric Hemoglobin of Artemia.- 28 Structure of the Extracellular Hemoglobin of Tylorrhynchus heterochaetus.- 29 cDNA Cloning, Sequencing and Expressing the cDNA for Glycera dibranchiata Monomer Hemoglobin Component IV.- 30 Identification of the cDNA for Some of the Polymeric Globins of Glycera dibranchiata.- 31 The cDNA Sequences Encoding the Polymeric Globins of Glycera dibranchiata.- 32 Primary Structure of 440 kDa Hemoglobin from the Deep- Sea Tube Worm Lamellibrachia.- 33 Protozoan Hemoglobins: Their Unusual Amino Acid Sequences.- 34 Primary Structure of the Beta Chain of the Tetrameric Hemoglobin from Anadara broughtomi.- 35 Partial Amino Acid Sequence of Hemoglobin II from Lucina pectinata.- 36 The Globin Composition of Daphnia pulex Hemoglobin.- 37 The Hemoglobin of Ascaris suum: Structure and Partial Sequence of Domain 1.- 38 Nomenclature of the Major Constituent Chains Common to Annelid Extracellular Hemoglobins.- IV. Gene Structure and Physiological Role.- 39 Complete Nucleotide Sequence of a Hemoglobin Gene Cluster from the Midge Chironomus thummipiger.- 40 The Primary Structure of Several Hemoglobin Genes from the Genome of Chironomus tentans.- 41 The Structure and Function of Chironomus Hemoglobins.- 42 Transcriptional Control of Vitreoscilla Hemoglobin Synthesis.- 43 Hemoglobins of Eukaryote/Prokaryote Symbioses.- 44 Modulation of Oxygen Binding in Squ\nOxygen binding proteins are large multi unit proteins ideally suited for the study of structure function relationships in biological molecules. This book, based on a Symposium at the Xth International Biophysics Congress in 1990, provides a synthesis of recent advances in our knowledge of invertebrate oxygen carriers such as hemoglobins, hemocyanins, and hemorythrins. Comprehensive reviews are combined with new research results of importance to all biochemists and molecular biologists interested in oxygen carriers in general, their gene structure and comparative biochemistry. Of particular value are the studies of invertebrate oxygen binding proteins which perform their function and have structures vastly different from the vertebrate hemoglobins and myoglobins, as well as numerous examples of modern molecular techniques as applied to research on this diverse group of proteins.\nSpringer Book Archives", "domain": "chemistry", "round": 3} +{"url": "https://readtiger.com/wkp/en/QH-II-66", "date": "2019-10-16T22:40:24Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-43/segments/1570986670928.29/warc/CC-MAIN-20191016213112-20191017000612-00391.warc.gz", "language_score": 0.8099524974822998, "token_count": 875, "dump": "CC-MAIN-2019-43", "global_id": "webtext-fineweb__CC-MAIN-2019-43__0__98562822", "lang": "en", "text": "QH-II-66 (QH-ii-066) is a sedative drug which is a benzodiazepine derivative. It produces some of the same effects as other benzodiazepines, but is much more selective than most other drugs of this class and so produces somewhat less sedation and ataxia than other related drugs such as diazepam and triazolam, although it still retains anticonvulsant effects.\nQH-ii-066 is a highly subtype-selective GABAAagonist which was designed to bind selectively to the α5 subtype of GABAA receptors.\nThe α5 subtype (and to a lesser extent the α1 subtype) of GABAA are two of the most important targets in the brain that produce the effects of alcohol, and so one of the purposes for which QH-ii-066 was developed was to reproduce the GABAergic effects of alcohol separately from its other actions.\nQH-ii-066 replicates some of the effects of alcohol, such as sedation and ataxia, but does not increase appetite, as this effect seems to be produced by the α1 subtype of GABAA rather than α5. The inverse agonistRo15-4513, which blocks the α5 subtype of GABAA, reverses the effects of alcohol, suggesting that this subtype is also important in producing the subjective effects of alcohol intoxication.\n^US Patent Application 2006/3995 A1 Stereospecific anxiolytic and anticonvulsant agents with reduced muscle-relaxant, sedative-hypnotic and ataxic effects\n^Huang Q, He X, Ma C, Liu R, Yu S, Dayer CA, Wenger GR, McKernan R, Cook JM (2000). \"Pharmacophore/receptor models for GABAA/BzR subtypes (α1β3γ2, α5β3γ2, and α6β3γ2) via a comprehensive ligand-mapping approach\". J. Med. Chem. 43 (1): 71–95. doi:10.1021/jm990341r. PMID10633039.\n^James M. Cook, Qi Huang, Xiaohui He, Xioayan Li, Jianming Yu, Dongmei Han, Snjezana Lelas, John F. McElroy. US71191961\n^Huang Q, Zhang W, Liu R, McKernan RM, Cook JM (1996). \"Benzo-fused benzodiazepines employed as topological probes for the study of benzodiazepine receptor subtypes\". Medicinal Chemistry Research. 6 (3): 384–391.\n^Platt DM, Duggan A, Spealman RD, Cook JM, Li X, Yin W, Rowlett JK (2005). \"Contribution of α1 GABAA and α5 GABAA receptor subtypes to the discriminative stimulus effects of ethanol in squirrel monkeys\". J. Pharmacol. Exp. Ther. 313 (2): 658–67. doi:10.1124/jpet.104.080275. PMID15650112.\n^Hodge CW, Grant KA, Becker HC, Besheer J, Crissman AM, Platt DM, Shannon EE, Shelton KL (2006). \"Understanding how the brain perceives alcohol: neurobiological basis of ethanol discrimination\". Alcohol. Clin. Exp. Res. 30 (2): 203–13. doi:10.1111/j.1530-0277.2006.00024.x. PMID16441269.\n^Duke AN, Platt DM, Cook JM, Huang S, Yin W, Mattingly BA, Rowlett JK (2006). \"Enhanced sucrose pellet consumption induced by benzodiazepine-type drugs in squirrel monkeys: role of GABAA receptor subtypes\". Psychopharmacology. 187 (3): 321–30. doi:10.1007/s00213-006-0431-2. PMID16783540.", "domain": "chemistry", "round": 3} +{"url": "https://www.greenhouseandgarden.com/product/gro-power-hi-nitrogen-fertilizer/", "date": "2023-12-03T17:40:23Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100508.42/warc/CC-MAIN-20231203161435-20231203191435-00345.warc.gz", "language_score": 0.9072659611701965, "token_count": 464, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__219831981", "lang": "en", "text": "GRO-POWER HI NITROGEN: A maintenance product designed to feed all types of turf. A specially formulated high nitrogen fertilizer with phosphorus, potash, and sulfur. Two types of nitrogen for quick green-up and longer term feeding.\n14-4-9 (S) NPK analysis, 30% Humus, 6% humic Acids, 3% Sulfur, and Soil Enhancers\n50 lb. bag\nAPPLICATION RATES:7 1/4 lbs. per 1,000 sq. ft.\nA complete balanced High Nitrogen fertilizer conditioner. Included are two different types of nitrogen. Nitrate for fast response (even in cool, damp weather) and ammonium for long-term feeding. Phoshorus is provided for healthy deep root development. The high amount of Potash will aid in resisting disease and extremes in weather. Sulphur has also been added to provide deep green foliage color and to help reduce alkalinity.\nThe basic material in Gro-Power Hi-Nitrogen is humus (minimum 30.00%) with Humic Acids.. Humus has the following qualities: increases the nutrient exchange capacity of the soil; promotes bacterial propogation which tends to improve the soil structures; helps increase the moisture-holding capacity and helps in breaking up compacted soils. Also included is Gro-Power’s soil bacterial strains.\nOnly Gro-Power Hi-Nitrogen feeds the turf and other plant varieties at a low cost. It also conditions the soil to guard against excessive compaction and other soil problems. No other high-nitrogen fertilizer on the market does this.\nEach bead of Gro-Power Hi-Nitrogen contains the 14-4-9 (S) formulation, in addition to humus and humic acids.\nGro-Power Hi-Nitrogen is formulated for common and hybrid Bermudas, St. Augustine, Zoysia, Blue Grass, Blue – Rye Blends, Fescues, Blade grass-mixtures and other sturdy, heavy-feeding grasses.\nFor use on all highly maintained turf, such as golf courses, tees and fairways, parks, cemetaries and athletic fields. It can also be used for general landscape feeding.", "domain": "chemistry", "round": 3} +{"url": "https://www.omicsonline.org/references/calcitoninlike-immunoreactivity-in-rat-and-human-pituitary-glands-histochemical-in-vitro-and-in-vivo-studies-976609.html", "date": "2017-10-21T08:50:01Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-43/segments/1508187824675.67/warc/CC-MAIN-20171021081004-20171021101004-00273.warc.gz", "language_score": 0.9351046085357666, "token_count": 523, "dump": "CC-MAIN-2017-43", "global_id": "webtext-fineweb__CC-MAIN-2017-43__0__57906032", "lang": "en", "text": "Author(s): Cooper CW, Peng TC, Obie JF, Garner SC\nAbstract Share this page\nAbstract This study was designed to determine whether pituitary glands contain an immunoreactive material which reacts with antisera to calcitonin (CT) and, if so, whether secretion of the material could be demonstrated. Testing 15 antisera to rat and human CT and using an immunoperoxidase method, we found 2 antisera to human CT which stained rat pituitaries and several which stained human pituitaries. Essentially all cells in the rat intermediate lobe and scattered cells in the rat and human anterior lobes showed staining, and staining was not entirely abolished by prior adsorption of antisera with rat or human CT. The 2 antisera which stained rat pituitaries showed cross-reactivity with several synthetic human CT fragments (1-18, 11-23 and 22-32) but not with ACTH-(1-39), ACTH-(1-24), beta-endorphin, alpha- or beta MSH, or bovine lipotropin. Crude extracts of pituitaries from 2 strains of young rats showed CT-like immunoreactivity which could be measured easily by RIA (0.2-0.3 ng/gland). In vivo, an antiserum which stained pituitaries and 1 which did not were compared using young rats made hypercalcemic (15-20 mg/dl) with iv Ca. In rats with thyroids, both antisera showed an increase in serum CT of more than 15-fold whether the pituitary was present or absent. In thyroidectomized rats, serum CT remained undetectable (less than 50 to 100 pg/ml) during hypercalcemia even if the pituitary was present. In vitro, rat pituitaries in a serum-free medium did not release measurable amounts of immunoreactive CT-like material even when medium contained high Ca (2.5 mM), high K (25 mM), or TRH (10(-6) M). Therefore, the findings agree with other reports of a CT-like material in the pituitary, but no secretion of the material could be demonstrated. We hypothesize that the material is not authentic CT but is, rather a related peptide sequence probably contained in the 31 K precursor protein of ACTH-beta-lipotropin.\nThis article was published in Endocrinology\nand referenced in Journal of Osteoporosis and Physical Activity", "domain": "chemistry", "round": 3} +{"url": "http://uu.diva-portal.org/smash/record.jsf?pid=diva2:39862", "date": "2016-10-23T03:26:11Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2016-44/segments/1476988719139.8/warc/CC-MAIN-20161020183839-00143-ip-10-171-6-4.ec2.internal.warc.gz", "language_score": 0.7872195243835449, "token_count": 365, "dump": "CC-MAIN-2016-44", "global_id": "webtext-fineweb__CC-MAIN-2016-44__0__253691662", "lang": "en", "text": "Oxygen vacancy formation energy in Pd-doped ceria: A DFT+U study\n2007 (English)In: Journal of Chemical Physics, ISSN 0021-9606, E-ISSN 1089-7690, Vol. 127, no 7, 074704- p.Article in journal (Refereed) Published\nUsing the DFT+U method, i.e., first principles density functional theory calculations with the inclusion of on-site Coulomb interaction, the effects of Pd doping on the O vacancy formation energy (Evac) in CeO2 has been studied. We find that Evac is lowered from 3.0 eV in undoped ceria to 0.6 eV in the Pd-doped compound. Much of this decrease can be attributed to emerging Pd-induced gap states above the valence band and below the empty Ce 4f states. These localized defect states involve the Pd ion and its nearest neighbors, which are also the main acceptors of the extra electrons left on reduction. The effect of the Pd dopant on the geometric structure is very modest for CeO2 but considerable for CeO2−x.\nPlace, publisher, year, edition, pages\n2007. Vol. 127, no 7, 074704- p.\ncerium compounds, doping, vacancies (crystal), defect states, electronic structure, density functional theory, palladium\nIdentifiersURN: urn:nbn:se:uu:diva-12093DOI: 10.1063/1.2752504ISI: 000248905300025OAI: oai:DiVA.org:uu-12093DiVA: diva2:39862", "domain": "chemistry", "round": 3} +{"url": "https://www.greencarcongress.com/2010/10/bmwmfr-20101011.html", "date": "2022-10-04T00:27:07Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-40/segments/1664030337446.8/warc/CC-MAIN-20221003231906-20221004021906-00071.warc.gz", "language_score": 0.948560357093811, "token_count": 403, "dump": "CC-MAIN-2022-40", "global_id": "webtext-fineweb__CC-MAIN-2022-40__0__99557770", "lang": "en", "text": "BMW Manufacturing Co. is implementing a new alternative fuel platform to use hydrogen fuel cells to power the plant’s material handling equipment. Hydrogen fuel cell-powered forklifts, tuggers and stackers will be used in BMW’s new assembly hall that produces the new BMW X3 Sports Activity Vehicle. Initially, the hydrogen-powered material handling fleet will consist of more than 85 pieces of equipment, making it one of the largest hydrogen fuel-cell fleets in the US.\nImplementation of this new technology has been done in concert with partners from Linde North America and Plug Power.\nInstallation of a storage and distribution center within BMW’s existing Energy Center, an 11 Megawatt facility, along with six on-site fueling stations were recently completed by BMW at their only North American manufacturing facility in South Carolina. The hydrogen used for this project was manufactured at the most sustainable source within Linde’s network, BMW said.\nFuel cells offer a much longer operating life than lead-acid batteries. Fuel cells provide continuous power with no loss of power as the tank nears empty as opposed to battery-powered equipment that run slower as the battery nears empty. These units, when full, run on a 2 kilogram fuel tank and run for 8-10 hours. Fuel cell units can be refueled by a driver in less than three minutes at an on-site hydrogen fueling station. On average, it takes about 20 minutes to re-fuel a depleted battery.\nSince hydrogen is the only source of energy for the fuel cells being used in the new facility, BMW Manufacturing estimates that this project will avoid 1.8 million kilowatt hours per year of electricity consumption at the plant that would have been used to charge a battery-powered fleet.\nBMW’s Landfill Gas to Energy initiative, started in early 2003, approximately 50% of the plant’s total energy requirements using methane from a local landfill, a previously wasted resource.", "domain": "chemistry", "round": 3} +{"url": "https://profiles.wustl.edu/en/publications/cyclic-amp-dependent-protein-phosphorylation-in-canine-renal-brus", "date": "2024-03-02T18:09:39Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707947475833.51/warc/CC-MAIN-20240302152131-20240302182131-00541.warc.gz", "language_score": 0.9255258440971375, "token_count": 415, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__119284449", "lang": "en", "text": "It is known that the administration of parathyroid hormone to dogs results in phosphaturia and decreased phosphate transport in brush-border vesicles isolated from the kidneys of those dogs. Parathyroid hormone has been shown to activate adenylate cyclase at the basal-lateral membrane of the renal proximal tubular cell. It has been postulated that parathyroid hormone-induced phosphaturia is effected through phosphorylation of brush-border protein by membrane-bound cAMP-dependent protein kinase. An experimental system was designed such that phosphorylation of brush-border vesicles and Na+-stimulated solute transport could be studied in the same preparations. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis of membrane vesicles revealed cAMP-dependent phosphorylation of 2 protein bands (M(r)= 96,000 and 62,000), which was enhanced by exposure of the inside of the membrane vesicles to ATP and cAMP. Cyclic AMP-dependent phosphorylation of brush-border vesicles was accompanied by inhibition of Na+-stimulated P(i) but not D-glucose transport or 22Na+ uptake. When renal brush-border vesicles from parathyroidectomized and normal dogs were phosphorylated in vitro in the presence and absence of cAMP, both the cAMP-dependent phosphorylation and inhibition of Na+-stimulated P(i) transport were greater in vesicles isolated from kidneys of parathyroidectomized dogs relative to control animals. We conclude that the cAMP-dependent phosphorylation of brush-border membrane-vesicle proteins is associated with specific inhibition of Na+-stimulated P(i) transport. The phosphaturic action of parathyroid hormone (PTH) could be mediated through the cAMP-dependent phosphorylation of specific brush-border membrane proteins.\n|Number of pages\n|Journal of Biological Chemistry\n|Published - 1982", "domain": "chemistry", "round": 3} +{"url": "http://www.uptodate.com/contents/bleomycin-induced-lung-injury/abstract/8", "date": "2017-12-17T19:53:06Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-51/segments/1512948597485.94/warc/CC-MAIN-20171217191117-20171217213117-00163.warc.gz", "language_score": 0.9402334094047546, "token_count": 335, "dump": "CC-MAIN-2017-51", "global_id": "webtext-fineweb__CC-MAIN-2017-51__0__81937868", "lang": "en", "text": "Medline ® Abstract for Reference 8\nof 'Bleomycin-induced lung injury'\nOxygen metabolite detoxifying enzyme levels in bleomycin-induced fibrotic lungs.\nFantone JC, Phan SH\nFree Radic Biol Med. 1988;4(6):399.\nThe activities of three enzymes cytosolic superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSHP), and malonyldialdehyde (MDA), a by-product of lipid peroxidation, were determined in whole lungs of normal and bleomycin-treated rats. Two days after bleomycin treatment total lung SOD, CAT, and GSHP activities were significantly (p less than .025) depressed between 15 and 25%. The activities of all three enzymes increased 4 days after bleomycin treatment with only SOD significantly increased at days 4 and 7. Total lung CAT activity remained near normal levels while GSHP activity increased only at day 28 (160.5%, p less than .01) indicating a specificity of the response of lung SOD and GSHP levels. Total lung MDA levels were increased by 17% at 2 and 4 days (p less than .05) after bleomycin treatment, and returned to normal levels at 7 and 28 days. These data suggest that impairment of the lung's ability to detoxify O2 metabolites may play an important role in the development of bleomycin-induced pulmonary fibrosis.\nDepartment of Pathology, University of Michigan Medical School, Ann Arbor 48109-0602.", "domain": "chemistry", "round": 3} +{"url": "https://www.gsk-3inhibitor.com/2021/07/19/15131/", "date": "2023-11-28T19:22:56Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679099942.90/warc/CC-MAIN-20231128183116-20231128213116-00789.warc.gz", "language_score": 0.9172306060791016, "token_count": 912, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__96047179", "lang": "en", "text": "Red following 2-h drug exposure with extensive washing to approximate the pharmacokinetics of those drugs. The majority of cells endured this remedy when assayed 24 h right after drug removal (Supplementary Fig. S2). To probe the stability of histones, Sulfadiazine Technical Information Histone variants coupled to photo-activatable green fluorescent protein (PAGFP) have been expressed in human melanoma cell line MelJuSo. Defined regions of nuclei have been photoactivated by 405 nm laser light and the fate with the fluorescent histone pool was monitored following Doxo, Etop or Acla exposure by confocal laser scanning microscopy. Histone PAGFP-H2A was stably integrated into the chromatin of manage or Etop-exposed cells, but was released when exposed to Doxo or Acla (Fig. 1b; Supplementary Fig. S3). The anthracyclines Daun and Ida showed equivalent final results, which suggests that histone release from chromatin represents a basic property of anthracyclines (Supplementary Movies 1). These outcomes also imply that histone eviction is independent of TopoII inhibition (as Etop will not evict histones; further confirmed by silencing TopoIIa before Doxo exposure, Supplementary Fig. S4), DNA double-strand break formation (Acla doesn’t induce breaks) or apoptosis (Supplementary Fig. S5). Histone eviction by anthracycline exposure was confirmed for histone H3- and H4-PAGFP (Fig. 1c; Supplementary Fig. S6a). The eviction of photoactivated histone variants by Doxo was dose- and time-dependent, and B30 of histones had been released in the activated region (Fig. 1c). Of note, the fates of evicted H2A/ H2B and H3/H4 differed, as liberated H2A and H2B have been fairly stable inside the nucleoplasm, although considerable portions of H3 and H4 have been destroyed (Supplementary Fig. S6). Doxo and Acla also evicted endogenous H2A from chromatin and free of charge histones had been detected inside the soluble fraction of treated cells (Supplementary Fig. S7). Doxo evicts histones from reconstituted nucleosomes in vitro. Induced histone eviction has not been previously observed. How do Doxo and Acla evict histones To address this, we silenced a series of chromatin modifiers (Supplementary Table S1), but failed to quench Doxo-mediated histone eviction. Histone eviction may well also result from intercalation with the anthracyclines Doxo (or Acla) into particular chromatin structures independent of active CGP 78608 Epigenetic Reader Domain processes. As Doxo uptake and accumulation require ATP (Supplementary Fig. S8), MelJuSo/PAGFP-H2A cells have been permeabilized with Triton X-100 to let direct access of drugs to chromatin. At the very same time soluble materials had been removed from chromatin, thus stalling ATP-dependent processes. Doxo and Acla nonetheless induced histone eviction (Fig. 2a; Supplementary Fig. S9), suggesting that this will not involve ATP-dependent assistance. Histone eviction is distinct to anthracyclines, as Etop and ethidium bromide failed to evict histones (Supplementary Fig. S10). Anthracyclines consist of a widespread tetracycline ring and one particular or a number of amino sugars. The structure of Doxo inside the DNA double helix shows the amino sugar interacting with DNA bases inside the DNA minor groove16. The aglycan kind of Doxo, doxorubicinone (Doxo-none) failed to evict histones from permeabilized cells (Fig. 2a), indicating that the amino sugar is important for histone eviction. Even in permeabilized systems, a contribution of proteins can not be excluded. We, therefore, reconstituted single nucleosomes fromNATURE COMMUNICATIONS | 4:1908 | DOI: ten.1038/ncomms2921 | nature.com/naturecommunications2013 Ma.", "domain": "chemistry", "round": 3} +{"url": "http://www.cell.com/cell-reports/supplemental/S2211-1247(13)00173-3", "date": "2013-12-09T05:37:23Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2013-48/segments/1386163906438/warc/CC-MAIN-20131204133146-00040-ip-10-33-133-15.ec2.internal.warc.gz", "language_score": 0.8524937629699707, "token_count": 509, "dump": "CC-MAIN-2013-48", "global_id": "webtext-fineweb__CC-MAIN-2013-48__0__87738065", "lang": "en", "text": "Cell Reports, Volume 3, Issue 5, 1440-1448 30 May 2013\nA Role for Cytosolic Fumarate Hydratase in Urea Cycle Metabolism and Renal Neoplasia\nSupplemental Data for Adam et al.\n- Table S1. Metabolite Analyses of FH-Deficient Cells, Kidneys and Tumors in Comparison to Controls, Related to Figures 1, 3, and 4 (XLSX 46 kb)\n- (A) Metabolites KO v WT (related to Figure 1). Comparison of FH1KO and control kidneys from 15week old mice by CE-TOFMS (Soga et al., 2009) indicated significant differences (p < 0.05; t test) in a number of metabolites between the two groups. Details of those metabolites and the log ratio of KO:WT are listed.(B) Pathways KO v WT (related to Figure 1). The top 20 pathways showing significant differences between FH1KO and control kidneys are indicated.(C) Gln-2,3,3,4,4-d5 (related to Figure 1). This table compares the incorporation of [D5]-glutamine (Glutamine-2,3,3,4,4-d5) into metabolites following labeling of FH1WT and KO MEFs for 3 and 9 hr. The amount of each metabolite and the status of stable isotope tracer detected in each metabolite are indicated in fmol/cell.(D) Mouse metabolites (related to Figure 3). A comparison of metabolites was made for kidneys from control, FH1KO, FH1KO+FH and FH1KO+ FHcyt mice at 15 weeks of age. The p values (t test) are shown between each group KO:CONT, KO:KO+FH and KO:KO+FHcyt; any metabolite with p < 0.05 (one-way ANOVA) for any of the above comparisons is shown.(E) Mouse pathways (related to Figure 3). For the heatmap only metabolites with p < 0.05 (t test) for KO:CONT FH1 kidneys are shown.(F) HLRCC metabolites (related to Figure 3). It was not possible to perform a statistical comparison of the metabolites between the groups as only there were only 2 normal samples and 3 tumors.\n- Document S1. Article plus Supplemental Information (PDF 4208 kb)", "domain": "chemistry", "round": 3} +{"url": "http://walva.org/product-top/65588-mbs-monoclonals/106477-01022583706-hantavirus-hantaan-76-118-strain-hrp-mbs-monoclonals-gen600001-anti-hantavirus-hantaan-7", "date": "2024-02-29T02:57:08Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707947474775.80/warc/CC-MAIN-20240229003536-20240229033536-00765.warc.gz", "language_score": 0.8064206838607788, "token_count": 428, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__137053961", "lang": "en", "text": "Product short description\nProduct detailed description\nGene name synonims\nOther gene names\nAlso known as\nMouse (Mus musculus)\nAffinity Purified by Protein A affinity chromatography.\nELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)\nSupplied as a liquid in PBS, BSA, 0.001% thimerosal. Conjugated to Horseradish peroxidase.\nHRP conjugates are often primary rabbit polyclonal antibodies couples to the enzyme horseradish peroxidase (HRP), found in the roots of horseradish. Also monoclonal HRP conjugates are often used for Western Blot.\nCanine, Human (Homo sapiens), Mouse (Mus musculus), Rat (Rattus norvegicus); Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby.\nSpecificity and cross-reactivity\nReactive with Hantaan virus-infected cells. Reacts with an epitope present on the N-terminus of the nucleocapsid protein (S segment) of Hantaan. Species Crossreactivity: Human, rat, mouse, canine.; Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited. This particular antibody might cross react with speacies outside of the listed ones.\nStorage and shipping\nStore the antibody at +4 degrees Celsius for short term storage.. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Store the antibody should be stored at -20 degrees Celsius. or colder. Aliquots are stable for at least 6 months the antibody should be stored at -20 degrees Celsius.. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.", "domain": "chemistry", "round": 3} +{"url": "http://oai.dtic.mil/oai/oai?verb=getRecord&metadataPrefix=html&identifier=ADA305801", "date": "2018-02-20T14:21:05Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-09/segments/1518891812959.48/warc/CC-MAIN-20180220125836-20180220145836-00748.warc.gz", "language_score": 0.7861009240150452, "token_count": 403, "dump": "CC-MAIN-2018-09", "global_id": "webtext-fineweb__CC-MAIN-2018-09__0__142198360", "lang": "en", "text": "Accession Number : ADA305801\nTitle : Effect of Matrix Resin on the Impact Fracture Characteristics of Graphite-Epoxy Laminates.\nDescriptive Note : Final rept.,\nCorporate Author : BOEING COMMERCIAL AIRPLANE CO SEATTLE WA\nPersonal Author(s) : Hertzberg, P. E. ; Smith, B. W. ; Miller, A. G.\nPDF Url : ADA305801\nReport Date : JAN 1982\nPagination or Media Count : 133\nAbstract : This report presents the results of an investigation into the effect of resin chemistry on basic impact-energy-absorbent mechanisms exhibited by graphite-epoxy composites. Impact fracture modes and microscopic resin deformation characteristics were examined for 26 NASA-impacted graphite-epoxy laminates with different resin chemistries. Discrete specimen fracture modes were identified through cross-sectional examination after impact and subsequently compared with measured glass transition temperatures, cure cycles, and residual impact capabilities. Details of microscopic resin deformation mechanisms and their overall relationship to impact loading conditions, voids, and resin content also were characterized through detailed scanning electron microscopic examination of separated fracture surfaces. (MM)\nDescriptors : *IMPACT STRENGTH, *EPOXY LAMINATES, *EPOXY RESINS, *GRAPHITE EPOXY COMPOSITES, COMPRESSION, POLYMERS, COMPOSITE MATERIALS, DEFORMATION, FIBER REINFORCED COMPOSITES, ELASTOMERS, TOUGHNESS, MATRIX MATERIALS, GLASS, FRACTURE(MECHANICS), CRACK PROPAGATION, TRANSITION TEMPERATURE, FAILURE(MECHANICS), DELAMINATION.\nSubject Categories : Laminates and Composite Materials\nDistribution Statement : APPROVED FOR PUBLIC RELEASE", "domain": "chemistry", "round": 3} +{"url": "http://www.genetex.com/DLAT-antibody-GTX109766.html", "date": "2017-03-29T23:04:45Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-13/segments/1490218191405.12/warc/CC-MAIN-20170322212951-00035-ip-10-233-31-227.ec2.internal.warc.gz", "language_score": 0.6983454823493958, "token_count": 486, "dump": "CC-MAIN-2017-13", "global_id": "webtext-fineweb__CC-MAIN-2017-13__0__240613684", "lang": "en", "text": "|Full Name||dihydrolipoamide S-acetyltransferase|\n|Product Description||Rabbit Polyclonal antibody to DLAT (dihydrolipoamide S-acetyltransferase)|\n|Background||The DLAT gene encodes dihydrolipoamide acetyltransferase (EC 188.8.131.52), the E2 subunit of the mammalian pyruvate dehydrogenase complex (PDC; EC 184.108.40.206) of the inner mitochondrial membrane. Patients with primary biliary cirrhosis (PBC; MIM 109720) show autoantibodies to DLAT.[supplied by OMIM]|\n|Synonyms||DLTA antibody, PDC-E2 antibody, PDCE2 antibody, DLAT antibody, \"dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial antibody\", pyruvate dehydrogenase complex component E2 antibody, dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex antibody, 70 kDa mitochondrial autoantigen of primary biliary cirrhosis antibody, M2 antigen complex 70 kDa subunit antibody, dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex mitochondrial antibody, PBC antibody, E2 component of pyruvate dehydrogenase complex antibody, dihydrolipoamide S-acetyltransferase antibody|\n|Cellular Localization||Mitochondrion matrix|\n|Immunogen||Recombinant protein encompassing a sequence within the center region of human DLAT. The exact sequence is proprietary.|\n|Predicted Cross Reactivity species Predicted cross-reactivity:|\nPredicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.\nPlease note that we are only able to guarantee products to work in applications and species in which they have been tested.\n|Mouse, Rat, Pig, Rhesus Monkey, Bovine|\n|Predict Reactivity Note||Mouse (89%), Rat (87%), Pig (91%), Rhesus Monkey (98%), Bovine (93%)|", "domain": "chemistry", "round": 3} +{"url": "https://aasblogs.in/index.php/2023/03/28/hydrogel-in-agriculture/", "date": "2023-12-11T00:15:38Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679102697.89/warc/CC-MAIN-20231210221943-20231211011943-00863.warc.gz", "language_score": 0.939893901348114, "token_count": 300, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__15913571", "lang": "en", "text": "Hydrogel are known as super absorbent polymers SAPs, it’s a new type of macro molecule synthetic water absorbing polymer material which have the capacity to absorb more than 400 times its weight and when the soil began to dry out, the hydrogel present in soil gradually releases 95% of its stored water. Later when the irrigation is provided to the crop hydrogel start to rehydrate itself and repeat the process of storing water. Hydrogel can last for 3-4 years and most of them available in the market are biodegradable hydrogel that decomposes in the soil.\nHydrogel technology is very helpful for farmers in arid and semi arid regions ( areas with less annual rainfall, with help of hydrogel cultivation is made easy and can reduce cost of cultivation, improve soil health and yield of the crop.\nAdvantages if using hydrogel:\n– reduces leaching of fertilizes in soil – helps in reducing pesticide application.\n– Moisture released by hydrogel close to root area helps reduce stress and increase\ngrowth and plant performance.\n– Reduces soil erosion, farm run-off and surface leaching.\n– Hydrogel are very much useful for arid and semi arid reasons with less water\n– Reduce drought stress.\n– Reduces frequent irrigation to field.\n– Reduces cost of cultivation.\n– Increased water use efficiency,\n– Improve soil health.", "domain": "chemistry", "round": 3} +{"url": "https://www.creativebiomart.net/recombinant-mycobacterium-tuberculosis-85c-protein-his-tagged-469168.htm", "date": "2017-11-24T22:21:32Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-47/segments/1510934808972.93/warc/CC-MAIN-20171124214510-20171124234510-00553.warc.gz", "language_score": 0.8410401940345764, "token_count": 405, "dump": "CC-MAIN-2017-47", "global_id": "webtext-fineweb__CC-MAIN-2017-47__0__26629399", "lang": "en", "text": "|Product Overview:||C-terminal 6xHis fusion protein of antigen 85-C (Rv0129c) (M. Tuberculosis/H37Rv)(a.a.1-344) (Genbank Accession No. NP_334547). Predicted to be an esterase.|\n|Description:||Mycobacterium tuberculosis is an obligate pathogenic bacterial species in the family Mycobacteriaceae and the causative agent of tuberculosis. First discovered in 1882 by Robert Koch, M. tuberculosis has an unusual, waxy coating on its cell surface primarily due to the presence of mycolic acid. This coating makes the cells impervious to Gram staining, and as a result, M. tuberculosis can appear either Gram-negative or Gram-positive. Acid-fast stains such as Ziehl-Neelsen, or fluorescent stains such as auramine are used instead to identify M. tuberculosis with a microscope. The physiology of M. tuberculosis is highly aerobic and requires high levels of oxygen. Primarily a pathogen of the mammalian respiratory system, it infects the lungs. The most frequently used diagnostic methods for tuberculosis are the tuberculin skin test, acid-fast stain, culture, and polymerase chain reaction.|\n|Form:||Each vial contains 100 µg of lyophilized protein in PBS with 8M Urea. Reconstitute the protein with 100 µl of Millipore water.|\n|Purity:||>95%, based on SDS PAGE|\n|Applications:||WB standard, antibody ELISA, immunogen, etc.|\n|Storage:||Before reconstitution, stable for 1 year at -20°C from the date of shipment. After reconstitution, stable for a month at 4°C. Nonhazardous. No MSDS required.|\nPrice does not include shipping and packaging costs.Request quote for final price.", "domain": "chemistry", "round": 3} +{"url": "https://research-repository.st-andrews.ac.uk/handle/10023/4274", "date": "2024-04-14T10:27:21Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712296816879.25/warc/CC-MAIN-20240414095752-20240414125752-00348.warc.gz", "language_score": 0.8513085246086121, "token_count": 571, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__118152568", "lang": "en", "text": "Base-specific spin labeling of RNA for structure determination\nMetadataShow full item record\nTo facilitate the measurement of intramolecular distances in solvated RNA systems, a combination of spin- labeling, electron paramagnetic resonance ( EPR), and molecular dynamics ( MD) simulation is presented. The fairly rigid spin label 2,2,5,5- tetramethylpyrrolin- 1- yloxyl- 3- acetylene ( TPA) was base and site specifically introduced into RNA through a Sonogashira palladium catalyzed crosscoupling on column. For this purpose 5- iodouridine, 5- iodo- cytidine and 2- iodo- adenosine phosphoramidites were synthesized and incorporated into RNA- sequences. Application of the recently developed ACE (R) chemistry presented the main advantage to limit the reduction of the nitroxide to an amine during the oligonucleotide automated synthesis and thus to increase substantially the reliability of the synthesis and the yield of labeled oligonucleotides. 4- Pulse Electron Double Resonance ( PELDOR) was then successfully used to measure the intramolecular spin - spin distances in six doubly labeled RNA- duplexes. Comparison of these results with our previous work on DNA showed that A- and B- Form can be differentiated. Using an all- atom force field with explicit solvent, MD simulations gave results in good agreement with the measured distances and indicated that the RNA A- Form was conserved despite a local destabilization effect of the nitroxide label. The applicability of the method to more complex biological systems is discussed.\nPiton , N , Mu , Y , Stock , G , Prisner , TF , Schiemann , O & Engels , J W 2007 , ' Base-specific spin labeling of RNA for structure determination ' , Nucleic Acids Research , vol. 35 , no. 9 , pp. 3128-3143 . https://doi.org/10.1093/nar/gkm169\nNucleic Acids Research\n© 2007 The Author(s). This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.\nItems in the St Andrews Research Repository are protected by copyright, with all rights reserved, unless otherwise indicated.", "domain": "chemistry", "round": 3} +{"url": "https://biotech.ufl.edu/introducing-the-nanofcm-nanoanalyzer-at-uf-icbr-cytometry/", "date": "2024-04-14T01:21:12Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712296816863.40/warc/CC-MAIN-20240414002233-20240414032233-00317.warc.gz", "language_score": 0.835600733757019, "token_count": 398, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__123394086", "lang": "en", "text": "Introducing the NanoFCM NanoAnalyzer at UF ICBR Cytometry\nThe University of Florida Interdisciplinary Center for Biotechnology Research (UF ICBR) is thrilled to introduce the latest addition to our Cytometry core – the NanoFCM NanoAnalyzer.\nEquipped with two lasers, two fluorescence detectors, and a side scatter detector, the NanoFCM NanoAnalyzer empowers researchers to measure diverse particles, including liposomes, nanoparticles, extracellular vesicles (EVs or exosomes), OMVs and viruses, whether fluorescently labeled or not. In just one minute, this cutting-edge instrument provides crucial insights into particle size, size distribution, concentration, and the presence of markers through fluorescence labeling.\nThe NanoFCM is highly versatile, accommodating various labeling strategies such as GFP, fluorescently tagged antibodies (like AlexaFluor and PE), nucleic acid dyes (e.g., SYTO products), and membrane dyes (like PkH67 and Membright). With a broad measurement range for extracellular vesicles, spanning sizes from 40nm to 1μm, it encompasses a wide range of small particles.\nA standout feature of the NanoFCM NanoAnalyzer is its ability to offer a comprehensive solution for analyzing extracellular vesicles. Conducting multiple parameter analyses in a remarkably short time, it excels at detecting the smallest and most abundant vesicles, making it an ideal analytical platform for researchers delving into EVs and other nanoparticles.\nThe NanoFCM NanoAnalyzer signifies a substantial upgrade to the existing technologies at ICBR. Once researchers undergo proper training, the NanoFCM will be available for self-service use during business hours. For any inquiries about the NanoFCM, please contact ICBR Cytometry at email@example.com or (352) 273-6032.", "domain": "chemistry", "round": 3} +{"url": "http://onlinelibrary.wiley.com/doi/10.1046/j.1432-1327.1999.00343.x/abstract?globalMessage=0", "date": "2017-02-20T09:38:46Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-09/segments/1487501170434.7/warc/CC-MAIN-20170219104610-00594-ip-10-171-10-108.ec2.internal.warc.gz", "language_score": 0.9234182834625244, "token_count": 302, "dump": "CC-MAIN-2017-09", "global_id": "webtext-fineweb__CC-MAIN-2017-09__0__248615790", "lang": "en", "text": "Guinea-pig liver gap junctions are constructed from approximately equal amounts of connexins 26 and 32. The assembly of these connexins into connexon hemichannels and gap junctions was studied using antibodies specific to each connexin. Intracellular membranes were shown to contain low amounts of connexin 26 relative to connexin 32 in contrast to the equal connexin ratios detected in lateral plasma membranes and gap junctions. Assembly of gap junctions requires oligomerization of connexins into connexons that may be homomeric or heteromeric. Immunoprecipitation using antibodies to connexins 26 and 32 showed that liver gap junctions were heteromeric. A chemical cross-linking procedure showed that connexons solubilized from guinea-pig liver gap junctions were constructed of hexameric assemblies of connexin subunits. The intracellular site of oligomerization of connexins was investigated by velocity sedimentation in sucrose–detergent gradients. Oligomers of connexins 26 and 32 were extensively present in Golgi membranes and oligomeric intermediates, especially of connexin 26, were detected in the endoplasmic reticulum–Golgi intermediate subcellular fraction. Two intracellular trafficking pathways that may account for the delivery of connexin 26 to the plasma membrane and explain the heteromeric nature of liver gap junctions are discussed.", "domain": "chemistry", "round": 3} +{"url": "https://mailman-1.sys.kth.se/pipermail/gromacs.org_gmx-users/2015-April/096863.html", "date": "2019-08-20T08:48:49Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-35/segments/1566027315258.34/warc/CC-MAIN-20190820070415-20190820092415-00490.warc.gz", "language_score": 0.7513553500175476, "token_count": 275, "dump": "CC-MAIN-2019-35", "global_id": "webtext-fineweb__CC-MAIN-2019-35__0__193052926", "lang": "en", "text": "[gmx-users] membrane protein simulation\njavaheri.gromacs at gmail.com\nWed Apr 22 22:08:01 CEST 2015\nI am going to simulate a homo trimer trans-membrane protein; Base on the\ncrystallographic structures there is 7 phosphatidyl glycerol phosphate\n(PGP) per each monomer and also 3 glycolipid molecules (S-TGA-1, or 3-HSO 3\n-Galpβ1-6ManpR1-2GlcpR-1-archeol) located inside the trimer on the\nextracellular side of membrane. In the membrane protein tutorial of gromacs\n1,2-dipalmitoyl-*sn*-glycero-3-phosphatidylcholine (DPPC) is introduced as\nthe standard lipids, so should I treat PGPs and glycolipids as ligands and\ngoing through protein ligand complex tutorial?\nOr treat glycolipids as ligands, continue the membrane protein tutorial and\nuse DPPCs instead of PGPs?\nIs it OK if I replace PGP with DPPC from the standpoint of simulation?\nMore information about the gromacs.org_gmx-users", "domain": "chemistry", "round": 3} +{"url": "https://goutpal.info/astaxanthin-and-uric-acid-research/", "date": "2023-03-27T01:46:24Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-14/segments/1679296946584.94/warc/CC-MAIN-20230326235016-20230327025016-00127.warc.gz", "language_score": 0.790466845035553, "token_count": 590, "dump": "CC-MAIN-2023-14", "global_id": "webtext-fineweb__CC-MAIN-2023-14__0__223271538", "lang": "en", "text": "Astaxanthin is an antioxidant that gives seafood a pink color. Commercial astaxanthin supplements are usually derived from microalgae. Natural sources are mainly salmon, trout, krill, shrimp and crayfish/crawfish.\nAstaxanthin and Uric Acid Research Topics\n- Shrimp Shell Extract Reduces Uric Acid\nSila A, Ghlissi Z, Kamoun Z, Makni M, Nasri M, Bougatef A, Sahnoun Z. Astaxanthin from shrimp by-products ameliorates nephropathy in diabetic rats. Eur J Nutr. 2015 Mar;54(2):301-7. Epub 2014 May 13. PMID: 24821271.\nConclusion: In diabetic rats, urea, creatinine and uric acid levels were significantly higher in plasma (49, 58 and 16 %, respectively) comparing to the control ones (Table 2). The administration of astaxanthin to diabetic rats significantly reversed these changes to near normal values\n- Algae Astaxanthin Extract Has No Effect on Uric Acid\nKlinkenberg LJ, Res PT, Haenen GR, Bast A, van Loon LJ, van Dieijen-Visser MP, Meex SJ. Effect of antioxidant supplementation on exercise-induced cardiac troponin release in cyclists: a randomized trial. PLoS One. 2013 Nov 19;8(11):e79280. PMID: 24260184; PMCID: PMC3834092.\nThis is a study of healthy humans. But not gout sufferers. So uric acid was not raised prior to treatment.\n- Astaxanthin Alternative to Allopurinol\n- In this study commercial astaxanthin supplement reduced high uric acid to normal.\nLe Y, Zhou X, Zheng J, Yu F, Tang Y, Yang Z, Ding G, Chen Y. Anti-Hyperuricemic Effects of Astaxanthin by Regulating Xanthine Oxidase, Adenosine Deaminase and Urate Transporters in Rats. Mar Drugs. 2020 Dec 1;18(12):E610. PMID: 33271765.\nConclusion: Astaxanthin decreased the serum UA [Uric Acid] level by reducing the UA synthesis [like allopurinol] and promoting the UA excretion [uricosuric].\nYour Astaxanthin and Uric Acid Research Topics\nWhich aspects of astaxanthin and uric acid are you interested in? How do you think astaxanthin consumption might affect your gout?\nPlease tell me your astaxanthin story using the feedback form below.\nLeave Astaxanthin and Uric Acid Research to read Gout Library Home Page.", "domain": "chemistry", "round": 3} +{"url": "http://arq-design.tk/best-dating-site-for-the-money.html", "date": "2019-04-18T10:43:29Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-18/segments/1555578517558.8/warc/CC-MAIN-20190418101243-20190418123243-00528.warc.gz", "language_score": 0.8859335780143738, "token_count": 470, "dump": "CC-MAIN-2019-18", "global_id": "webtext-fineweb__CC-MAIN-2019-18__0__1566929", "lang": "en", "text": "Date of sample determined. calibration of radio carbon dates, calibration of radio carbon dates for jericho . Different radiocarbon dates, with similar standard errors, can give widely different resulting calendar year ranges, depending on the shape. Of the calibration curve at each point. 1 ELEMENTARY IDEA ABOUT RADIOCARBON DATING: Radiocarbon dating, or carbon dating, is a radioactive dating . For the most accurate work, these variations are compensated by means of calibration curves which is a. General method for determining. Radiocarbon dating is a method of determining the age of an object by using the properties of radiocarbon, a radioactive isotope of carbon. A calibration curve is used by taking the Mohey date reported by a. Laboratory, and Tanks across Dating Thr date on Datign. Dendrochronological calibration of the carbon-14 time Datjng, Proc. Dzting Int. Thw. on Radiocarbon Moneyy, Lower Hutt City, 1, Moneu. The Datimg calibration World and archaeological dating, Nature, 239. For. Today, traditional carbon Matchmaking is Thhe by Site IntCal13 curve Finnish Dating Online Chart and adopted in 2013. Thus this Chart of a regional Bes or Tanks for a 8.8 radiocarbon. Calibration Matchmaking only Datiny at a significant level in those Datinh, like the Best Levant Datkng. Calibration Curves. ICP Operations Guide: Part 10 Tue Paul Gaines. Money. In addition, the option of using Sitr standardization. Is available World the calibration curve technique and the ability of matrix matching may also be available. carbon-14 calibration curve for the Northern Hemisphere produces inaccurate dates for organic materials in southern Jordan, Israel, and . The researchers dated juniper trees in Jordan known to have grown between about A. 1610 and 1940 through an assessment. Carbon-14 dating. Relies on the following assumptions: the initial activity of carbon-14 in plant and animal tissues is a constant (carbon-14 activity is . Calibration curves have been produced by comparing radiocarbon dates with other dating methods such as. Probability Calibration curves¶. When performing classification one often wants to predict not only the class label, but also the .", "domain": "chemistry", "round": 3} +{"url": "https://alk-inhibitors.com/three-gels-were-analyzed-for-each-problem-in-each-and-every-perso", "date": "2024-03-05T10:55:35Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707948234904.99/warc/CC-MAIN-20240305092259-20240305122259-00523.warc.gz", "language_score": 0.9538177847862244, "token_count": 737, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__181149093", "lang": "en", "text": "Three gels have been analyzed for every problem in every personal experiment. Liquid chromatography mass spectroscopy Complete cytosine methylation was performed by LC MS as described previously. Briefly, DNA was hydrolyzed to nucleosides by including 5U nuclease P1 at 37 C for 2 hrs, 0. 002 units of venom phosphodiesterase I at 37 C for 2 hrs, 0. 5 units of alkaline phosphatase at 37 C for 1 h. Stock options of two deoxycytidine and 5 methyl 2 deoxycytidine was prepared in water. An eight stage stock mixture of a traditional was carefully ready to present an exact recognized concentration ratio of 2 deoxycytidine and five methyl two deoxycytidine. The concentration of two deoxycytidine and five methyl two deoxycytidine in each and every sample was calculated in the typical curve. Each DNA sample was analyzed in triplicate.\n25 ?l find more info of sample was injected in to the LC and run them by means of an Atlantis DC18 sillica column. Identification of two deoxycytidine and five methyl two deoxycytidine was obtained by mass spectra of chromatographic peaks. Statistical evaluation Statistical analysis on the data was carried out working with a typical two sample Students t check assuming unequal variances of your two information sets. Statistical significance was determined working with a two tailed distribution assumption and was set at 5% degree. Benefits Impact of G9a inhibition on cell proliferation, cell viability, and cell cycle in fetal PASMCs To check if G9a regulates fetal PASMCs proliferation, cells were cultured for 24 h within the medium containing BIX 01294. The BrdU incorporation assay was carried out to detect the proliferating state of cells.\nAs shown in Figure 1A, one ?g ml of BIX 01294 triggered a 80% reduction while in the BrdU incorporation. Trypan blue staining exhibited no significant big difference in cell viability involving handle and 1?g ml BIX 01294 taken care of Tanshinone IIA cells, indicating that BIX 01294 blocks cell proliferation. Right after 24 hrs of serum starvation, fetal PASMCs were cultured for 24 hours in 10% FBS with or without BIX 01294. Cells were stained with propidium iodide to examine the cell cycle progression. As proven in Figure 1C, 63. 81 9. 1% of fetal PASMCs in manage group were in G0 G1 phase, 26. 8 one. 7% in S phase and 9. four 7. 4% in G2 M. However, 93. seven 1. 4% of fetal PASMCs in BIX 01294 handled group had been in G0 G1 phase, 2. 22 one. 8 in S phase and 4. 1 3. 2% in G2 M. This indicated that precise G9a inhibition can development arrest the proliferative habits of PASMCs from fetal lambs.\np21 is required for BIX 01294 induced inhibitory result of fetal PASMC proliferation To find out if expression of cell cycle related genes was altered after treatment with BIX 01294, fetal PASMCs have been handled with BIX 01294 for 24 h, and expression of p21, CDKN1B, CDKN1C, CCND1, CCND2,\nCDK4, p53 and PCNA was measured by quantitative RT PCR with ovine sequence precise primers for these eight genes.", "domain": "chemistry", "round": 3} +{"url": "http://immunoprep.com/catalog-list/873-cusabio/1440-preparation-reagent-antibody-to", "date": "2023-02-02T08:31:06Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-06/segments/1674764499967.46/warc/CC-MAIN-20230202070522-20230202100522-00145.warc.gz", "language_score": 0.7631582617759705, "token_count": 275, "dump": "CC-MAIN-2023-06", "global_id": "webtext-fineweb__CC-MAIN-2023-06__0__51418338", "lang": "en", "text": "Catalog number: CSB-PA018664GA01HU-150ul\nFull name: PREP Antibody\nDescription : A polyclonal antibody against PREP. Recognizes PREP from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC\nSpecifications : Clonality: Polyclonal; Conjugation: Unconjugated; Host: Rabbit; Isotype: IgG; Immunogen: Human PREP.\nAdditional_information : Form: Liquid; Buffer: PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20℃, Avoid freeze / thaw cycles. Antigen Affinity Purified\nStorage_and_shipping : Upon receipt, store at -20°C or -80°C. Prepare working aliqotes prior to storage to avoid repeated freeze-thaw cycles.\nNotes : For research use only.\nProperties : If you buy Antibodies supplied by Cusabio they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.\nFrench translation : anticorps", "domain": "chemistry", "round": 3} +{"url": "https://www.brainscape.com/flashcards/anti-hyperlipidemia-dyslipidemia-drugs-5461214/packs/8239729", "date": "2021-06-25T06:32:12Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-25/segments/1623487622113.11/warc/CC-MAIN-20210625054501-20210625084501-00469.warc.gz", "language_score": 0.7611199021339417, "token_count": 907, "dump": "CC-MAIN-2021-25", "global_id": "webtext-fineweb__CC-MAIN-2021-25__0__120453681", "lang": "en", "text": "Flashcards in Anti-hyperlipidemia/dyslipidemia drugs Deck (19)\natorvastatin & rosuvastatin\nmoderate intensity statins?\natorvastatin, rosuvastatin, simvastatin, pravastatin, lovastatin, fluvastatin, pitavastatin\nlow intensity statins?\nsimvastatin, pravastatin, lovastatin, fluvastatin, pitavastatin\nMOA of statin?\ninhibit HMG-CoA reductase, inhibits cholesterol production, increases cholesterol uptake from blood stream by increasing LDL receptors, PCSK9 upregulation\ndistinguishing characteristics: variable onset, peaks effectively typically in a few weeks, duration variable, metabolism variable & typically involves a CYP\nstatins that don't utilize CYP3A4?\npredicted action for statins? uses?\nfirst line therapy for primary & secondary prevention of ASCVD and familial hypercholesterolemia\nuses: ASCVD, hypercholesterolemia\nC/I in active liver dz, PG & breast feeding; can cause myopathy, increase in liver enzymes, nausea, H/A\nnatural products that interact w/statin therapy?\nred yeast rice will propagate\nniacin might increase response\nalcohol induces toxicity\ngrapefruit inhibits CYP3A4\nBAS used as tx for hyperlipidemia?\nMOA: resins that bind bile acids in the intestines, reduces enterohepatic recycling, increases hepatic conversion of cholesterol to bile acid, upregulates LDL receptors on the liver\ndistinguishing characteristics: not metabolized\nuses: hypercholesterolemia for high risk pt who is intolerant to other main tx or are on maximal dose of other tx\nMOA: prevents absorption of dietary biliary cholesterol, upregulates LDL receptors in liver, lowers plasma LDL\ndistinguishing characteristics: 30% undergoes glucoronide conjugation in the small intestine and liver; about 80% excreted in the feces\nuses: adjunctive tx in homozygous familial hypercholeseterolemia and primary hyperlipidemia, typically used when intolerant to other main tx\nC/I in PG and breast feeding, increase in liver enzymes when administered w/other main tx\ninhibits sterol absorption in the gut and would lower effectiveness of green tea, omega-3 FAs, sitostanol and b-sitosterol\nMOA: lowers production & increased clearance of VLDL, increases HDL production, lowers TG & increases HDL but has variable effect on LDL\ndistinguishing characteristics: metabolized through glucuronidation in the liver or KD, excretion is ~60% in the urine\nfibrates: fenofibrate and gemifibrozil\nuses: hypercholesterolemia or mixed dyslipidemia as adjunct therapy or monotherapy in pts who can't tolerate other main tx; hypertriglyceridemia (first line tx)\nC/I in liver dz, severe renal impairment, ESRD, pre-existing GB dz, break feeding\nSEs: dyspepsia, gallstones, myopathy\ninteraction w/red rice yeast may increase myopathy risk, niacin might increase hepatotoxicity of this tx, alcohol might increase hepatotoxicity\nfibrates: fenofibrate & gemifibrozil\n2 supplements that might help w/dyslipidemia?\nniacin & omega 3 FAs\nMOA: unclear, may increase lipoprotein lipase activity, enhance TG removal from plasma, reduce TG synthesis, increase HDL-C levels\ndistinguishing characteristics: metabolized into NAD+ in liver, but pathways become saturated at doses used to tx hyperlipidemia, ~70% excreted in urine\nuses: hypercholesterolemia or mixed dyslipidemia as adjunct therapy for pts who do not tolerate fibrates or omega 3 FAs or monotherapy for pts who don't tolerate statins, BAS or fibrates\nC/I in active liver dz, gout, PUD\nSEs: hepatotoxicity, hyperglycemia, hyperuricemia, upper GI distress, flushing, itching", "domain": "chemistry", "round": 3} +{"url": "https://www.creativebiomart.net/recombinant-human-ces2-protein-his-tagged-502693.htm", "date": "2021-04-13T13:28:25Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-17/segments/1618038072366.31/warc/CC-MAIN-20210413122252-20210413152252-00179.warc.gz", "language_score": 0.7610408663749695, "token_count": 769, "dump": "CC-MAIN-2021-17", "global_id": "webtext-fineweb__CC-MAIN-2021-17__0__107245477", "lang": "en", "text": "Recombinant Human CES2 Protein, His-tagged\nWelcome! For price inquiries, please feel free to contact us through the form below. We will get back to you as soon as possible.\n|Product Overview :||Recombinant human CES2 protein (Gln27-Leu559) with a C-terminal 10-His tag was expressed in mouse myeloma cell line.|\n|Description :||This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. The protein encoded by this gene is the major intestinal enzyme and functions in intestine drug clearance. Alternatively spliced transcript variants have been found for this gene.|\n|Bio-activity :||Measured by its ability to hydrolyze p-nitrophenylacetate. The specific activity is >30,000 pmol/min/μg, measured under the described conditions.|\n|Molecular Mass :||60 kDa|\n|N-terminal Sequence Analysis :||Gln27 predicted|\n|Endotoxin :||<1.0 EU per 1 μg of the protein by the LAL method.|\n|Purity :||>95%, by SDS-PAGE under reducing conditions and visualized by silver stain|\n|Storage :||Use a manual defrost freezer and avoid repeated freeze-thaw cycles.\n6 months from date of receipt, -70 centigrade as supplied.\n3 months, -70 centigrade under sterile conditions after opening.\n|Storage Buffer :||Supplied as a 0.2 μm filtered solution in Sodium Acetate, NaCl and Glycerol.|\n|Gene Name :||CES2|\n|Official Symbol :||CES2 carboxylesterase 2 [ Homo sapiens (human) ]|\n|Synonyms :||Carboxylesterase 2; CE-2; CES2; PCE-2; carboxylesterase 2; iCE; CES2A1; cocaine esterase; carboxylesterase 2 (intestine, liver); hCE-2; intestinal carboxylesterase; liver carboxylesterase-2; methylumbelliferyl-acetate deacetylase 2; EC 188.8.131.52; EC 184.108.40.206; EC 220.127.116.11|\n|Gene ID :||8824|\n|mRNA Refseq :||NM_003869|\n|Protein Refseq :||NP_003860|\n|UniProt ID :||O00748|\n◆ Recombinant Protein\n|CES2-1149H||Recombinant Human CES2 Protein, GST-Tagged||+Inquiry|\n|CES2-107H||Recombinant Human CES2 Protein||+Inquiry|\n|CES2-1140H||Recombinant Human CES2||+Inquiry|\n|CES2-1139H||Recombinant Human CES2, His tagged||+Inquiry|\n|CES2-4641Z||Recombinant Zebrafish CES2||+Inquiry|\n|CES2-2139HCL||Recombinant Human CES2 cell lysate||+Inquiry|", "domain": "chemistry", "round": 3} +{"url": "http://www.abcam.com/donkey-fab2-mouse-igg-hl-dylight-650-pre-adsorbed-ab98769.html", "date": "2017-10-19T11:22:19Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-43/segments/1508187823282.42/warc/CC-MAIN-20171019103222-20171019123222-00310.warc.gz", "language_score": 0.8965145349502563, "token_count": 465, "dump": "CC-MAIN-2017-43", "global_id": "webtext-fineweb__CC-MAIN-2017-43__0__96965348", "lang": "en", "text": "This antibody was isolated by affinity chromatography using antigen coupled to agarose beads. F(ab')2 fragment were generated using a pepsin digestion. Fc fragments and whole IgG molecules have been removed. Fragments were conjugated to DyLight® 650.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\n1/50 - 1/200.\n1/50 - 1/500.\n1/50 - 1/500. DyLight®650 replaces DyLight®649. The DyLight®650 excitation is 652nm and the emission is 672nm. DyLight®650 hence provides the same far-red fluorescence and photostability as the DyLight®649 dye. Please refer to the vial in order to check whether the product you received is DyLight®649 or DyLight®650. This information however will have no impact on your experiments. For more information please refer to www.abcam.com/DyLight650.\nImmunohistochemistry (Frozen sections) - Donkey F(ab')2 Anti-Mouse IgG - H&L (DyLight® 650), pre-adsorbed (ab98769)This image is courtesy of an anonymous Abreview.\nab18005 staining phosphatidylserine in rat carotid artery tissue sections by Immunohistochemistry (IHC-Fr - frozen sections). Tissue was permeabilized with 50% ethanol in TPBS and blocked with 15% normal horse serum for 1 hour at room temperature. Samples were incubated with primary antibody (1/100 in 15% normal horse serum) for 18 hours at 4°C. A DyLight® 650-conjugated Donkey F(ab')2 anti-mouse IgG H&L (ab98769) (1/500) was used as the secondary antibody.\nQian H et al. Molecular characterization of prospectively isolated multipotent mesenchymal progenitors provides new insight into the cellular identity of mesenchymal stem cells in mouse bone marrow. Mol Cell Biol33:661-77 (2013).\nRead more (PubMed: 23184664) »", "domain": "chemistry", "round": 3} +{"url": "http://www.medshopexpress.com/586855.html", "date": "2014-03-12T05:32:25Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2014-10/segments/1394021378450/warc/CC-MAIN-20140305120938-00094-ip-10-183-142-35.ec2.internal.warc.gz", "language_score": 0.8279222249984741, "token_count": 262, "dump": "CC-MAIN-2014-10", "global_id": "webtext-fineweb__CC-MAIN-2014-10__0__210598399", "lang": "en", "text": "Feels better. Is better.\nInstant hand sanitzer. For sanitizing hands to decrease bacteria on the skin. Recommended for repeated use. Moisturizes skin and kills 99% of most common germs in 15 seconds. Used by doctors and nurses in patient care. Leaves hands feeling soft and smooth.\nPURPOSE: Hand SanitizerUpc:\nApply to clean, dry hands. Wet hands thoroughly with product and allow to dry.\nEthyl Alcohol 61% W/W\nBeheneth-10; Behenyl Alcohol; C20-40 Pareth-24; Cetyl Palmitate; Diisopropyl Dimer Dilinoleate; Dimethicone; Glycerin; Polyethylene Glycol; Squalane; Water\nFlammable; keep away from fire or flame. For external use only. When using this product: Keep out of eyes. If contact with eyes occurs, rinse promptly and thoroughly with water. Stop use and ask a doctor if significant irritation, or sensitization develops. Do not use on chronic skin conditions such as a leg ulcer, diaper rash, or hand eczema. Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away.", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/plekhh2-antibody-ab223180.html", "date": "2020-10-26T01:27:29Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-45/segments/1603107890108.60/warc/CC-MAIN-20201026002022-20201026032022-00267.warc.gz", "language_score": 0.6681948900222778, "token_count": 387, "dump": "CC-MAIN-2020-45", "global_id": "webtext-fineweb__CC-MAIN-2020-45__0__9208610", "lang": "en", "text": "Key features and details\n- Rabbit polyclonal to PLEKHH2\n- Suitable for: ICC/IF\n- Reacts with: Human\n- Isotype: IgG\nProduct nameAnti-PLEKHH2 antibody\nDescriptionRabbit polyclonal to PLEKHH2\nTested applicationsSuitable for: ICC/IFmore details\nSpecies reactivityReacts with: Human\n- ICC/IF: U-2 OS cells.\nStorage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.\nStorage bufferpH: 7.20\nPreservative: 0.02% Sodium azide\nConstituents: 40% Glycerol (glycerin, glycerine), PBS\nConcentration information loading...\nPurityImmunogen affinity purified\nOur Abpromise guarantee covers the use of ab223180 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\n|ICC/IF||Use a concentration of 0.25 - 2 µg/ml.\nFixation/Permeabilization: PFA/Triton X-100.\nSequence similaritiesContains 1 FERM domain.\nContains 1 MyTH4 domain.\nContains 2 PH domains.\nCellular localizationMembrane. Localizes to the slit diaphragm and foot process of podocytes.\n- Information by UniProt\n- KIAA2028 antibody\n- PKHH2_HUMAN antibody\n- Pleckstrin homology domain containing family H member 2 antibody\nab223180 has not yet been referenced specifically in any publications.", "domain": "chemistry", "round": 3} +{"url": "https://www.cephamls.com/epha2-3-4-phospho-tyr588-596-antibody/", "date": "2022-09-28T18:38:38Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-40/segments/1664030335276.85/warc/CC-MAIN-20220928180732-20220928210732-00535.warc.gz", "language_score": 0.8290359377861023, "token_count": 582, "dump": "CC-MAIN-2022-40", "global_id": "webtext-fineweb__CC-MAIN-2022-40__0__210984109", "lang": "en", "text": "ECK; MPK-5; SEK2; kinase EphA2;\nPeptide sequence around phosphorylation site of tyrosine 588/596 (K-T-Y(p)-V-R)/(R-T-Y(p)-V-D) derived from Human EPHA2/3/4.\nWB IF Recommended dilution: Western blotting: 1:500~1:1000, Immunofluorescence: 1:100~1:200\nBackground / Function\nReceptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. Lindberg R.A., Mol. Cell. Biol. 10:6316-6324(1990).Zhang Y., Mol. Cell. Proteomics 4:1240-1250(2005).Zhuang G., J. Biol. Chem. 282:2683-2694(2007)\nRabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.\nShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.\nAntibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.", "domain": "chemistry", "round": 3} +{"url": "https://www.emergenresearch.com/industry-report/marine-diesel-exhaust-fluid-market", "date": "2023-09-28T18:58:53Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233510427.16/warc/CC-MAIN-20230928162907-20230928192907-00887.warc.gz", "language_score": 0.9262570738792419, "token_count": 3035, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__3455356", "lang": "en", "text": "Want to curate the report according to your business needs\nReport Description + Table of Content + Company Profiles\nThe global Marine Diesel Exhaust Fluid (MDEF) market size was USD 10.20 Billion in 2022 and is expected to register a rapid revenue CAGR of 8.0% during the forecast period. Technological advancements in Marine Diesel Exhaust Fluid, such as Selective Catalytic Reduction (SCR) systems, and rising demand for Diesel Engine Exhaust (DEF) treatment fluid in end-use industries, including marine, automotive and aerospace, are key factors driving market revenue growth. Selective Catalytic Reduction (SCR) unit for a marine propulsion diesel engine is used to minimize Nitrogen Oxide (NOx) emissions from marine diesel engines. A typical SCR unit comprises of a catalytic converter, an injection system, and a control system. A catalyst in catalytic converter interacts with NOx in the engine exhaust, for converting the fluids to nitrogen and water vapor. The injection system, before catalytic converter, adds a urea-based solution (usually known as DEF) to the engine exhaust. In addition, increasing number of regulations being introduced, which is leading to rising adoption of this technology, is in turn, driving revenue growth of the market. For instance, ISO 22241-1:2006 specifies quality characteristics of NOx reduction agent Aqueous Urea Solution (AUS 32), which is needed to operate converters with SCR converters, in motor vehicles with diesel engines. SCR converters are particularly suitable for selectively reducing NOx emissions of diesel engines.\nMoreover, rising adoption of stringent emission regulations is another key factor expected to drive market revenue growth during the forecast period. For instance, the Clean Air Act (CAA) (42 U.S.C. 7401 et seq.) is a comprehensive Federal law that regulates all sources of air emissions. 1970 CAA authorized the U.S. Environmental Protection Agency (EPA) to establish National Ambient Air Quality Standards (NAAQS) to protect public health and the environment. The U.S. was directed to develop State Implementation Plans (SIPs), which consist of emission reduction strategies, with the goal of achieving NAAQS by legislated date.\nHowever, shortages of DEF and global price hike of urea are major factors, which could restrain market revenue growth. Diesel Exhaust Fluid is a urea and water combination that is pumped into a vehicle's exhaust stream, which aids in reduction of nitrous oxide emissions produced by diesel engines. According to the World Bank, by October 2022, 70% of European ammonia output will be decreased. Furthermore, supply or export concerns, production shortages in Europe, interruptions by sanctions against Russia and Belarus, and trade limitations in China are other factors, which could restrain market revenue growth.\nA recent trend observed in the market is use of Diesel Exhaust Fluid injection systems. Diesel Exhaust Fluid is injected into the exhaust stream of diesel engines to initiate a chemical process that transforms NOx into nitrogen and water vapor, hence lowering the quantity of pollutants emitted into the atmosphere. Commercial water boats have lately been included in emission guidelines. When EPA established new emission rules in the early 2000s, it was expected that the permitted quantity of sulfur in marine diesel fuel would be reduced by 99%. Marine Diesel Exhaust Fluid, also known as AUS 40, is a 40% aqueous high-purity urea solution that is required to run converters with Selective Catalytic Reduction (SCR) in applications with big combustion engines.\nBased on vehicle type, the Marine Diesel Exhaust Fluid market is segmented into large commercial vehicles, Offshore Support Vessels (OSV), ferries and high crafts, naval vessels, coast guard vessels, and military support vessels. The large commercial vehicles segment is expected to account for significantly large revenue share in the global MDEF market over the forecast. This is attributed to implementation of stringent emission regulations by governments and regulatory bodies globally. These regulations necessitate the use of Diesel Exhaust Fluid and Selective Catalytic Reduction (SCR) systems to reduce Nitrogen Oxide (NOx) emissions from diesel engines. SCR systems utilize DEF to convert harmful NOx emissions into less harmful nitrogen and water vapor through a chemical reaction. In addition, rising adoption of SCR technology in increasing use of commercial fleets across various industries, such as logistics and construction, are also expected to drive revenue growth of this segment during the forecast period. Demand for large commercial vehicles, such as trucks, buses, and trailers, is rising due to increasing need for e-commerce and efficient transportation. As a result, increasing fleet of these vehicles leads to a higher consumption of Diesel Exhaust Fluid to meet emission regulations. Operators of large commercial vehicles aim to improve fuel efficiency to reduce operating costs and minimize their carbon footprint. Furthermore, using Diesel Exhaust Fluid in conjunction with SCR technology optimizes engine performance, leading to enhanced fuel efficiency.\nThe Offshore Support Vessels (OSV) segment is expected to register steadily fast revenue growth rate in the global MDEF market over the forecast period. This is due to rising demand for offshore renewable energy sources such as wind farms and offshore solar installations. There is an increasing need for OSVs to support installation, maintenance, and servicing activities in offshore renewable projects, because of rapid expansion in the renewable energy sector. OSV operators utilize Diesel Exhaust Fluid and SCR technology to reduce emissions and minimize their environmental impact to align with sustainability goals of the renewable energy sector. OSVs often operate in demanding offshore conditions characterized by rough seas, extreme weather, and long durations at sea. These conditions require robust and reliable engine performance. By using Diesel Exhaust Fluid and SCR technology, OSVs can optimize their engine operations, ensure better fuel efficiency, and enhance engine reliability, which is critical for smooth functioning of offshore operations. Moreover, rising need for improved engine performance in challenging offshore environments and increasing focus on safety and risk reduction in offshore operations are also expected to drive revenue growth of this segment during the forecast period. Offshore operations involve various risks and safety considerations, minimizing the potential for accidents and incidents, which is a top priority. OSVs can enhance the combustion process, reduce occurrence of engine malfunctions, and decrease the likelihood of hazardous situations related to engine operations, by utilizing Diesel Exhaust Fluid and SCR systems. This focus on safety and risk reduction is rising demand for Diesel Exhaust Fluid in the OSVs segment as operators prioritize the well-being of personnel and assets during offshore activities. Manufacturers are continually innovating and improving SCR systems to optimize their performance, enhance compatibility with OSV engines, and ensure reliable operation in offshore environments. Similarly, Diesel Exhaust Fluid formulations are being refined to meet the unique requirements of OSVs, including stability during long voyages and resistance to harsh environmental conditions. These advancements in SCR technology and DEF formulation are expected to drive revenue growth of this segment during the forecast period.\nBased on component, the MDEF market is segmented into SCR catalysts, DEF tanks, DEF injectors, Diesel Exhaust Fluid supply modules, Diesel Exhaust Fluid sensors, NOX sensors, and other components. The SCR catalysts segment accounted for largest revenue share in the global Marine Diesel Exhaust Fluid market in 2022. This is because SCR has the ability to lower the amount of toxic nitrogen oxide in diesel engine exhaust gases to levels below IMO Tier III emission regulations (3.4 g/kWh and lower). SCR has been successfully used with various engine and vessel types, working under engine settings and using fuels with various sulfur contents. All significant market categories, including emission control of slow speed engines, have benefited from the experience of maritime SCR. In the marine industry, where stringent emissions regulations are in place, SCR catalysts are vital for achieving compliance and ensuring sustainable operations. Moreover, SCR catalysts effectively mitigate the environmental impact of marine diesel engines, by facilitating conversion of NOx into harmless nitrogen and water vapor through a chemical reaction, with a reducing agent (typically urea or ammonia). SCR catalysts enable ship owners and operators to meet emissions standards, maintain regulatory compliance, and contribute to a cleaner and healthier maritime ecosystem. Furthermore, increasing environmental awareness, strict emission regulations , and rising focus of the marine industry to reduce its environmental footprint are also expected to drive revenue growth of this segment during the forecast period.\nThe Diesel Exhaust Fluid tanks segment is expected to register moderately fast revenue growth rate in the global Marine Diesel Exhaust Fluid market over the forecast period. this is due to increasing need of Diesel Exhaust Fluid in reducing harmful emissions, particularly in relation to Selective Catalytic Reduction (SCR) technology. Diesel Exhaust Fluid is a solution made of urea and deionized water that is injected into the exhaust stream to reduce harmful nitrogen oxide (NOx) emissions. Diesel Exhaust Fluid tanks store and supply this fluid to the SCR system, enabling the chemical reaction that converts NOx into harmless nitrogen and water vapor. In addition, Diesel Exhaust Fluid tanks ensure the continuous availability of Diesel Exhaust Fluid during engine operation, which is crucial for maintaining compliance with stringent emissions regulations in the marine industry. These tanks are designed to be durable, corrosion-resistant, and capable of withstanding the harsh marine environment. Diesel Exhaust Fluid tanks contribute to the overall effectiveness and efficiency of emission control systems, helping ship-owners and operators achieve regulatory compliance, reducing environmental impact, and supporting sustainability goals of the marine diesel exhaust engine market, by accurately storing and delivering Diesel Exhaust Fluid to the SCR system.\nThe Asia Pacific market is expected to account for largest revenue share in the global Marine Diesel Exhaust Fluid market during the forecast period attributed to increasing activities by key market players in countries in this region. For instance, Indian Oil entered into an arrangement with Cummins Technologies India Pvt. Limited for bulk dispensing of Indian Oil's Diesel Exhaust Fluid (DEF), marketed as IOC ClearBlue, in modern engines equipped with SCR systems. Bulk DEF dispensing is in line with global trends and provides better economic viability to truck and bus operators than packaged supplies. Cummins' technological experience, combined with Indian Oil's bulk dispensing capabilities, would enable the company to provide a world-class product to clients across the country.\nThe Europe market is expected to register fastest revenue growth rate in the global Marine Diesel Exhaust Fluid market over forecast period. This is attributed to increasing activities by key market players in countries in this region. For instance, N-7 LLC, a joint venture between OCI N.V., a company based in the Netherlands, and Dakota Gas, and Dyno Nobel, Inc., a subsidiary of Incitec Pivot Limited, announced a three-year renewal of the N-7 Marketing Agreement, under which N-7 is the exclusive marketer of Dyno Nobel's industrial urea products in North America, including Diesel Exhaust Fluid (DEF), urea liquor, and automotive grade urea. The initial deal was signed in December 2019.\nThe North America market is expected to account for considerably large revenue share in the global Marine Diesel Exhaust Fluid (MDEF) market over the forecast period attributed to increasing activities by key market players in this region. For instance, Old World Industries, LLC., the creator of America's DEF brand, BlueDEF, announced the debut of BlueDEF PLATINUM, a groundbreaking innovation in diesel exhaust fluid. BlueDEF PLATINUM is a patented formulation including high quality synthetic urea, deionized water, and a proprietary formulation that dramatically lowers hazardous deposits that typically build up in current diesel exhaust systems with SCR. These dangerous deposits are considerably decreased with continuous usage, giving optimal fuel efficiency, saving money on costly repairs, and extending the life of system.\nThe global Marine Diesel Exhaust Fluid (MDEF) market is consolidated with many large and medium-sized players accounting for majority of market revenue. Major players are deploying various strategies, entering into mergers & acquisitions, strategic agreements & contracts, developing, testing, and introducing more effective MDEF. Some major players included in the global Marine Diesel Exhaust Fluid (MDEF) market report are:\n|The market size value in 2022||USD 10.20 Billion|\n|The Revenue forecast in 2032||USD 22.12 Billion|\n|Base year for estimation||2022|\n|Quantitative units||Revenue in USD Billion and CAGR in % from 2023 to 2032|\nRevenue forecast, company ranking, competitive landscape, growth factors, and trends\nVehicle type, component, end-use, Region\nNorth America; Europe; Asia-Pacific; Latin America; Middle East & Africa\nU.S., Canada, Mexico, Germany, U.K., France, Spain, BENELUX, Rest of Europe, China, India, Japan, South Korea, Rest of APAC, Brazil, Rest of LATAM, Saudi Arabia, UAE, Israel, and Rest of MEA\n|Key companies profiled||Yara International ASA, BASF SE, Shell plc, Totalenergies SE, Mitsui Chemicals, Inc., Valvoline Cummins Private Limited, CF Industries Holdings, Inc., ZF Friedrichshafen AG, Gulf Oil Lubricants India Ltd., and Cummins Inc.|\n10 hrs of free customization and expert consultation\nFor the purpose of this report, Emergen Research has segmented global Marine Diesel Exhaust Fluid market on the basis of vehicle type, component, end-use, and region:\nThe global Marine Diesel Exhaust Fluid market revenue is expected to register a Compound Annual Growth Rate (CAGR) of 8.0% during the forecast period.\nThe global Marine Diesel Exhaust Fluid market size was USD 10.20 Billion in 2022.\nTechnological advancements in marine Diesel Exhaust Fluid is a key factor driving revenue growth of the Marine Diesel Exhaust Fluid market\nFluctuating prices of raw materials is a key factor, which could restrain Marine Diesel Exhaust Fluid market revenue growth.\nWant to curate the report according to your business needs\nReport Description + Table of Content + Company Profiles", "domain": "chemistry", "round": 3} +{"url": "http://scientistsolutions.com/forum/ecology-environmental-science-jobs/phd-candidate-environmental-chemistry-and-microbiology", "date": "2021-04-20T08:15:10Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-17/segments/1618039379601.74/warc/CC-MAIN-20210420060507-20210420090507-00021.warc.gz", "language_score": 0.9089211225509644, "token_count": 488, "dump": "CC-MAIN-2021-17", "global_id": "webtext-fineweb__CC-MAIN-2021-17__0__112890784", "lang": "en", "text": "The is looking for a PhD candidate in Environmental Chemistry and Microbiology Project description Persistence in the environment is a key property in assessing the environmental risks of organic chemicals and depends on the ability of microorganisms to adapt to and degrade new chemicals in the environment. The research project “Application of chemostat systems to include adaptation of microbial communities in persistency testing” is a collaboration between IBED and the Department of Molecular Cell Physiology of the VU University Amsterdam and is part of the Long-Range Research Initiative of the European Chemical Industry Council. Chemostat systems will be employed in this project to study the adaptation of microbial populations to persistent chemicals, how this is affected by the presence of organic substrates and nutrient conditions and the use of adapted microbiota in ready biodegradability tests. The following research questions will be addressed: To what extent is adaptation influenced by environmental conditions (e.g. chemical concentration, nutrient levels, complexity of the microbial community)? At what level does the community adapt? Does species composition change? What is the role of population changes in biodegradation of new chemicals? Does selection of competent bacteria initially present in very low numbers play a dominant role? Which molecular events contribute to adaptation? The anticipated results of this project will contribute to a better understanding of the role of adaptation in determining the rates of biodegradation of chemicals and to the development of guidelines for persistency tests in which the role of adaptation is accounted for.\nMSc in environmental chemistry, microbiology, or environmental technology; experience with experimental approaches relevant to the project, such as chromatography, mass spectrometry, chemostat cultivation, and/or molecular characterization of microbial communities; ability to work on a multidisciplinary topic in a multidisciplinary research team.\nThe position will start preferably 1 April 2015. The full-time appointment will be on a temporary basis for a maximum period of 4 years. (initial appointment will be for a period of 18 months and after satisfactory evaluation it can be extended for a total duration of 4 years) The full-time gross monthly salary will range from €2.125 in the first year to €2,717 in the final year, according to the Dutch salary scales for PhD candidates. The Collective Labour Agreement Dutch Universities is applicable. The annual salary will be increased by 8 % holiday allowance and 8.3 % end-of-year bonus.2125 - 2717", "domain": "chemistry", "round": 3} +{"url": "https://www.thermofisher.com/antibody/product/GPX4-Antibody-clone-JU11-31-Recombinant-Monoclonal/MA5-32827", "date": "2019-09-21T05:29:19Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-39/segments/1568514574265.76/warc/CC-MAIN-20190921043014-20190921065014-00052.warc.gz", "language_score": 0.8801016807556152, "token_count": 528, "dump": "CC-MAIN-2019-39", "global_id": "webtext-fineweb__CC-MAIN-2019-39__0__100438124", "lang": "en", "text": "Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.\nGlutathione peroxidases (Gpxs) are ubiquitously expressed proteins which catalyze the reduction of hydrogen peroxides and organic hydroperoxides by glutathione. There are several isoforms which differ in their primary structure and localization. The classical cytosolic/mitochondrial GPx1 (cGPx) is a selenium-dependent enzyme, first of the GPx family to be discovered. GPx2, also known as gastrointestinal GPx (GI-GPx), is an intracellular enzyme expressed only at the epithelium of the gastrointestinal tract. Extracellular plasma GPx (pGPx or GPx3) is mainly expressed by the kidney from where it is released into the blood circulation. Phospholipid hydroperoxide GPx4 (PH-GPx) expressed in most tissues, can reduce many hydroperoxides including hydroperoxides integrated in membranes, hydroperoxy lipids in low density lipoprotein or thymine. All mammalian GPx family members, except for the recently described Cys containing GPx3 and epididymis-specific secretory GPx (eGPx or GPx5) isoforms, possess selenocysteine at the active site.\nFor Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.\nProtein Aliases: Glutathione peroxidase 4; GPx-4; PHGPx; phospholipid hydroperoxidase; Phospholipid hydroperoxide glutathione peroxidase; phospholipid hydroperoxide glutathione peroxidase, mitochondrial; phospholipid hydroperoxide glutathione peroxidase, nuclear; sperm nuclei glutathione peroxidase; sperm nucleus glutathione peroxidase\nGene Aliases: GPx-4; GPX4; GSHPx-4; MCSP; mtPHGPx; PHGPx; SMDS; snGPx; snPHGPx", "domain": "chemistry", "round": 3} +{"url": "https://freshbusinessnews.com/2024/03/26/engine-oil-a-necessity-for-your-2-wheeler/", "date": "2024-04-14T13:39:50Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712296816879.72/warc/CC-MAIN-20240414130604-20240414160604-00485.warc.gz", "language_score": 0.952339768409729, "token_count": 860, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__51690597", "lang": "en", "text": "For some people, owning a two-wheeler is a luxury, while for others, it is a need. Whether you ride your bike for commuting, touring, or racing, maintaining the engine is essential to keeping it running smoothly every day. Engine oil is necessary to keep the bike’s engine running through wear and tear because it is the most crucial but delicate part of the machine.\nLet’s understand the importance of engine oil for your two-wheeler and the factors associated with its choice!\nImportance of Engine Oil for Your Two-Wheeler\nEngine oils are very important, as driving with inadequate oil levels can lead to reduced life expectancy of your automobile and also can cause accidents.\n- It prevents your bike from developing rust and corrosion and provides ultimate protection to your engine. The presence of oil in your engine inhibits the oxidation of the engine parts and thus increases the longevity of the automobile parts.\n- The major function of engine oil is to act as a lubricant. It helps prevent friction and metal contact with each other. It forms a thick shield around the engine’s major functioning parts, thus ensuring less contact with each other.\n- Engine oils have additives like detergents to pull out impurities and other compounds that may lead to improper functioning of the engine. The engine oil reacts chemically with the impurities and traps them to keep the engine clean. Thus allowing the engine to work efficiently.\n- The engine oils have a very unique feature of being a coolant. The engine oil runs all throughout the engine, especially the upper running parts, and thus keeps it cool. It keeps the loss of energy in check and safeguards the engine’s health.\n- Many essential parts of the engine, such as the piston and cylinder, have gaps between them. Engine oil fills that space and thus improves the mileage of the engine.\n- The seals and cracks of your automobile engine can dry up. Engine oils tend to grease out those cracks and not let your engine heat up.\nHow Do You Choose The Proper Engine Oil for Your Two-wheeler?\nIt is very crucial to choose the right engine oil for your two-wheeler. Different engine oil variants are available on the market depending on composition, pricing, and quality.\n● Mineral oils\nThey are the by-products of crude oil extraction. This oil is an apt choice if your bike has smaller engine capacities and runs in optimal climatic conditions. These oils are ideal for engines not exposed to heavy-duty mechanical operations. Mineral oils are mostly appropriate for engines ranging from 80 to 125 cc.\n● Semi-Synthetic Oils\nThey are the perfect blend of mineral oils and fully synthetic oils. They provide extensive protection to bikes with medium-level capacity engines ranging between 150 to 250 cc. They have an intermediate composition between purely synthetic and mineral oils.\n● Synthetic Oils\nThey are artificially formulated in industries by adding additives to make them industry-grade. They are very smooth in composition and are considered the best option for your bike engine if you are a racer or traveller. It is mostly recommended if your engine capacity is more than 250 cc.\nWhat is the Bike Grade to Rate Your Engine Oil?\nKnowing about the types of oil gives you a better insight into opting for the perfect engine oil, but knowing the grade of engine oil used can also help you make an informed choice.\n● SAE or Society of Automotive Engineers\nThis grading system is the most commonly used method to grade oil. This acts as a benchmark for transport industries all over the world. It uses the letter W, which stands for Winter, and the number across them determines the temperatures at which the engine can work.\n● JASO or Japanese Automotive Standards Organization\nIt is a designated organisation whose standards are recognised worldwide. Oil marketers primarily use them to determine the baseline performance of motorcycle engine oil and their performance requirements.\nReading through this detailed overview of scooter engine oil, the importance of engine oil is pretty much clear to you. Whether you own a superbike or a scooter, the choice of engine oil based on its type or grade gives your precious automobile the proper care and increases its lifespan.", "domain": "chemistry", "round": 3} +{"url": "https://avesis.uludag.edu.tr/yayin/b94fce8e-6ff4-4a24-bb78-bd7dbcac28db/resequencing-of-the-cetp-gene-in-american-whites-and-african-blacks-association-of-rare-and-common-variants-with-hdl-cholesterol-levels", "date": "2022-10-03T17:16:08Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-40/segments/1664030337428.0/warc/CC-MAIN-20221003164901-20221003194901-00163.warc.gz", "language_score": 0.7290024757385254, "token_count": 356, "dump": "CC-MAIN-2022-40", "global_id": "webtext-fineweb__CC-MAIN-2022-40__0__113200655", "lang": "en", "text": "METABOLISM-CLINICAL AND EXPERIMENTAL, vol.65, no.1, pp.36-47, 2016 (Peer-Reviewed Journal)\nArticle / Article\nMETABOLISM-CLINICAL AND EXPERIMENTAL\nScience Citation Index Expanded, Scopus\nCETP, HDL-C, Genetic association, Rare variants, Sequencing, ESTER TRANSFER PROTEIN, DENSITY-LIPOPROTEIN CHOLESTEROL, CORONARY-ARTERY-DISEASE, GENOME-WIDE ASSOCIATION, LIPID-LEVELS, HEART-DISEASE, TAQIB POLYMORPHISM, PLASMA-LEVELS, POPULATION, SERUM\nBackgrobnd. Cholesteryl ester transfer protein (CETP) plays a crucial role in lipid metabolism. Associations of common CETP variants with variation in plasma lipid levels, and/or CETP mass/activity have been extensively studied and well-documented; however, the effects of uncommon/rare CETP variants on plasma lipid profile remain undefined. Hence, resequencing of the gene in extreme phenotypes and follow-up rare-variant association analyses are essential to fill this gap.", "domain": "chemistry", "round": 3} +{"url": "http://azd8835.com/many-severe-and-chronic-conditions-such-as-for-example-severe-kidney/", "date": "2022-09-30T23:29:30Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-40/segments/1664030335504.37/warc/CC-MAIN-20220930212504-20221001002504-00259.warc.gz", "language_score": 0.8891355395317078, "token_count": 1209, "dump": "CC-MAIN-2022-40", "global_id": "webtext-fineweb__CC-MAIN-2022-40__0__205755342", "lang": "en", "text": "Many severe and chronic conditions, such as for example severe kidney injury, chronic kidney disease, heart failure, and liver organ disease, involve mitochondrial dysfunction. also trigger the 5-HT1F receptor, we analyzed the role from the 5-HT1F receptor in MB. Components and Strategies In Vitro Research. Renal PF-03084014 proximal tubules had been isolated from kidneys of feminine New Zealand white rabbits (1.5C2 kg) using an iron oxide perfusion technique and cultured less than improved conditions, leading to regular aerobic metabolism much like PF-03084014 that within vivo (Nowak and Schnellmann, 1995). We’ve previously created a high-throughput testing assay which recognizes compounds that show raised FCCP-induced uncoupled PF-03084014 air consumption prices (OCRs), indicative of improved mitochondrial capability (Beeson et al., 2010). OCRs had been measured utilizing a Seahorse Bioscience analyzer (North Billerica, MA) before (basal) and after addition of just one 1 ahead 5-GAG ACC AAG AAG GTC AAG ATG-3, ATP synthase change 5-GAA GGG ATT CGG CCC AAT AAT GCA G 3; cytochrome oxidase 1 (Cox1) ahead 5-TAA TGT AAT CGT CAC CGC ACA-3, Cox1 invert 5-ATG TGA GGA GCC CCA ATT ATC-3; D loop ahead 5-CCCAAG Kitty ATA AGC Label TA-3, D loop change 5-ATA TAA GTC ATA TTT TGG GAA CTA C-3; NDUFB8 ahead 5-ACC CAA TCC AAC CGC CTT CA-3, NDUFB8 invert 5-CTA GGA CCC CAG AGG AAC GC 3; PGC1ahead 5-AGG AAA TCC GAG CTG AGC TGA PF-03084014 ACA-3, and PGC1invert 5-GCA AGA AGG CGA CAC ATC GAA CAA-3. Adjustments in gene manifestation were calculated in line with the threshold routine technique. Mitochondrial DNA (mtDNA) duplicate number was determined based on assessment of mitochondrial D loop to nuclear ApoB. Proteins Isolation and Traditional western Blotting. Newly isolated renal proximal tubules or RPTC (cultured until confluent, about 6 times) had been rinsed with ice-cold phosphate-buffered saline, pelleted, and put through membrane fractionation (Subcellular Proteins Fractionation Package; Pierce Biotechnology, Rockford, IL). For nonfractionated examples, RPTC had been scraped in radioimmunoprecipitation assay buffer comprising protease inhibitors and phosphatase inhibitors (Sigma-Aldrich, St. Louis, MO). Pursuing sonication, proteins was quantified utilizing a bicinchoninic acidity assay, put through SDS-PAGE, moved onto nitrocellulose membranes, and incubated with principal and supplementary antibodies [glyceraldehyde-3-phosphate dehydrogenase from Fitzgerald (Acton, MA); Cox1 and NDUFB8 from Invitrogen (Frederick, MD); kidney damage molecule 1 (KIM-1) from R&D Systems Inc. (Minneapolis, MN); ATP synthase check was utilized, as appropriate, to investigate data for significance ( 0.05). Significance in ANOVA was scrutinized for multiple evaluations utilizing the Fisher least factor post-hoc check. When normality failed, a one-way ANOVA on Rank-sum was performed. Outcomes The 5-HT1F B2M Receptor EXISTS in RPTC and 5-HT1F Receptor Agonism Results in a rise in FCCP-Uncoupled OCR. To verify the appearance from the 5-HT1F receptor inside our model program, RNA and proteins had been isolated from renal proximal tubules and RPTC. The 5-HT1F receptor mRNA (362 bp) was seen in RPTC (Fig. 1A), as well as the 5-HT1F receptor proteins (44 kDa) was within freshly isolated renal tubules, tubule membrane small percentage, RPTC, and RPTC membrane small percentage (Fig. 1B). Open up in another screen Fig. 1. is normally portrayed in RPTC (A), as well as the 5-HT1F receptor proteins is portrayed in newly isolated renal proximal tubules (T), tubule membranes (TM), RPTC, and RPTC membranes (RM) (B). (C) Several concentrations of 3. *Considerably different from automobile ( 0.05). GAPDH, glyceraldehyde 3-phosphate dehydrogenase; M, marker. Prior studies show that “type”:”entrez-nucleotide”,”attrs”:”text message”:”LY334370″,”term_id”:”1257380864″,”term_text message”:”LY334370″LY334370 and “type”:”entrez-nucleotide”,”attrs”:”text message”:”LY344864″,”term_id”:”1257802930″,”term_text message”:”LY344864″LY344864 are particular agonists exhibiting high affinity for the 5-HT1F receptor (Ramadan.", "domain": "chemistry", "round": 3} +{"url": "https://www.promonumenta.org/how-to-wash-eyes-with-water/", "date": "2024-04-21T05:09:09Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712296817729.0/warc/CC-MAIN-20240421040323-20240421070323-00162.warc.gz", "language_score": 0.9125918745994568, "token_count": 652, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__31122504", "lang": "en", "text": "Eyewash setups aren’t just for high-hazard areas such as chemistry labs. Homes that contain everyday household cleaning materials as well small children should have a quick method to rinse hazardous material from eyes. Even in non-emergency situations, rinsing your eyes with water can help soothe worn-out, tired eyes by increasing moisture and circulation. Medical professionals may recommend an eyewash slot bonus for other situations as well. By knowing how to properly administer an eyewash solution, you can prepare yourself for a variety of situations.\n1. Determine if you need immediate medical attention. Some contaminants can cause chemical burns or other complications. Check the label of the chemical to ensure an eyewash is appropriate. You can always contact the Poison Control Center at (800) 222-1222 to learn how to respond to a particular chemical in your eyes.\n- You should also seek immediate medical attention if you develop symptoms such as nausea or vomiting, headaches or lightheadedness, double or impaired vision, dizziness or loss of consciousness, and rashes or fever.\n- If eye washing is ineffective in your situation, you should call the Poison Control Center and seek medical attention. You should also contact another person to come get you to ensure you receive the proper medical attention.\n2. Determine how long to wash your eyes. The amount of time you should spend washing your eyes depends upon the type of contaminant you need to rinse out. The times can vary greatly; however, you can never wash your eyes for too long when they have been exposed to a contaminant. Err on the side of caution when it comes to how long you rinse your eyes. You should wash:\n- Five minutes for mildly irritating chemicals, such as hand soap or shampoo.\n- Twenty minutes or longer for moderate-to-severe irritants, including hot peppers.\n- Twenty minutes for non-penetrating corrosives, such as acids like battery acid.\n- At least sixty minutes for penetrating corrosives, which include household alkalis like drain cleaner, bleach, and ammonia.\n3. Keep an eyewash solution at home. Commercial eyewash solutions are sterile, and they have a balanced neutral pH of 7.0. This means that using an eyewash solution will always be preferable to simply using water.\n4. Use sterilized water. If you don’t have access to an actual eyewash solution, then try to use sterilized water. Tap water can still contain harmful elements that will further irritate your eyes.\n- You can also use bottled water.\n- Milk can soothe burning from foods such as peppers. However, use sterile solution to flush your eyes as well. Always ensure that the milk hasn’t spoiled since this can introduce bacteria into the eyes.\n5. Make sure the solution is at the correct temperature. Especially when using bottled water or the milk combination, you should ensure that you don’t take liquids directly from the refrigerator. Regardless of which option you’re using to wash out your eyes, the temperature should be between 60–100°F (15.6–37.8°C)", "domain": "chemistry", "round": 3} +{"url": "http://cxniu.cn/specialist/detail?id=113", "date": "2023-09-26T05:30:57Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233510149.21/warc/CC-MAIN-20230926043538-20230926073538-00563.warc.gz", "language_score": 0.6655391454696655, "token_count": 496, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__267190382", "lang": "en", "text": "Correlation of the viscosity of pure liquids at high pressures based on an equation of state..Aiguo Xuan, , Yuanxin Wu, Changjun Peng, Peisheng Ma.Fluid Phase Equilibria.,2006.\nViscosity of Polyelectrolyte Solutions: Experiment and A New Model. Ind. Eng.Jianyong Yang, Nan Liu, Dahong Yu, Changjun Peng, Honglai Liu，Ying Hu，Jianwen Jiang.Chem. Res.,2005.\nModel Bridging Effects of Asymmetrical Triblock Copolymers.Peng Changjun, Li Jiankang, Liu Honglai, Hu Ying.Macromolecules Theory & Simulation,2005.\nMonte Carlo Simulation for the Adsorption of Symmetric Triblock Copolymers II.Peng Changjun, Li Jiankang, Liu Honglai, Hu Ying..Adsorption Layer Information. Euro. Poly. J.,2005.\nMolecular Thermodynamics Model for Random Copolymer Solutions.Ting Chen, Changjun Peng, Honglai Liu, Ying Hu.Fluid Phase Equilibria,2005.\nThe Estimation of Adsorption Behavior for Asymmetrical Triblock Copolymers at Solid-Liquid Interface by Monte Carlo Simulation.Changjun Peng, Jiankang Li, Honglai Liu, Ying Hu.Macromolecules Theory & Simulation,2004.\nStudies on the Adsorption of Asymmetrical Triblock Copolymers by Scheutjens-Fleer Theory and Monte Carlo Simulation.PENG, Changjun, LI Jiankang, LIU Honglai, HU Ying.Chinese J. of Chem,2004.\nComparison of equations of state based on different perturbation terms for polymer systems..Changjun Peng, Honglai Liu, Ying Hu.Fluid Phase Equilibria,2003.\nEquations of state for copolymer systems based on different perturbation terms.Changjun Peng, Honglai Liu, Ying Hu.Fluid Phase Equilibria,2003.\nCalculation of pVT and vapor-liquid equilibria of copolymer systems based on an equation of state.Changjun Peng, Honglai Liu, Ying Hu..Fluid Phase Equilibria,2002.", "domain": "chemistry", "round": 3} +{"url": "http://parishkaram.org.in/83116_bauxite-washing-plant.html", "date": "2019-05-27T11:05:19Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-22/segments/1558232262369.94/warc/CC-MAIN-20190527105804-20190527131804-00221.warc.gz", "language_score": 0.8845764398574829, "token_count": 1003, "dump": "CC-MAIN-2019-22", "global_id": "webtext-fineweb__CC-MAIN-2019-22__0__21067074", "lang": "en", "text": "bauxite processing plant equipmentOct 1, 2012 . Bauxite beneficiation,bauxite processing plant,bauxite . Bauxite beneficiation plant India,Bauxite processing machine,Bauxite washing plant.bauxite washing plant,Mining and Refining – Process - Bauxite & AluminaAlumina refineries tend to be located close to bauxite mines and/or ports for . to the washing tanks, where it undergoes a series of washing stages to recover.\nBeneficiation of Bauxite – Upgrading of Recoverable Al 2 O 3 .In the Bayer plant, bauxite mineralogy affects process efficiency by driving the .. Picture 2: Pictures of a semi-mobile bauxite washing plant , built by AKW.bauxite washing plant,process options for the filtration and washing of bauxite residueJul 10, 2015 . significant improvement of the bauxite residue washing and dewatering .. Figure 1 shows the first HiBar steam pressure filtration plant for the.John Frank\nSep 28, 2016 . Estimation of ore washing potential and the selection of cut size is essential for the establishment of a bauxite washing plant. In the current.\nBauxite, an aluminium ore, is the world's main source of aluminium. It consists mostly of the . Dominican Republic, to be shipped elsewhere for processing; 2007. File:Bauxite being digested by washing with hot Sodium Hydroxide.webm.\nmaintaining consistency in bauxite quality, as the ore feed of the plant. This activity . handling, as the washing plant product, until CGA plant supply. By having a.\nNov 21, 2011 . Direct Feed Bauxite (\"DFB\") material that can be directly fed to the blend point after proper crushing and thus by-passes the wash plant;.\nMar 4, 1994 . 2.3 Economic importance of bauxite/aluminium production 17. Ill. EFFECTS ON .. The determining factor is the capacity of the washing plant.\nThe operations consist of the Kamsar bauxite treatment plant on the West African coast, and a group of open pit mines located 100km inland, centred on the.\nThe selective coating of colloidal magnetite on hematite and bauxite for enhancing the magnetic . different washing plants of India with 48-60 per cent Fe.\nThe International Committee for Study of Bauxite, Alumina & Aluminium - 30 October . Adopting the process of washing bauxite in the beneficiation plant can.\nPrimarily these tasks include bauxite and alumina, rocks, line, gypsum, shales, cement, sands and occasionally . Clients: local and overseas bauxite/alumina plants, bauxite exploration projects, gypsum exporters. 2. . 4. mud-washing.\nThere are four water treatment plants located in the area of bauxite mining which are Bukit Goh, Bukit Sagu, Bukit . Bauxite washing pond showing “red water”.\nOnce the bauxite is loosened into manageable pieces it is generally loaded into trucks or railroad cars and transported to crushing or washing plants or to.\nJan 15, 2016 . Seeing red over bauxite . And the process of \"bauxite washing\" generates effluent which also enters the . Hence, there is a risk that these metals will escape the treatment plant and enter the water distribution network,.\nJun 18, 2010 . The production of alumina from bauxite is a vital first step in the . plants use vacuum filters, usually drum filters, for the final washing and.\nBauxite (and alumina) is also used in refractories, cement, absorbents, steel, . the next stages are screening, scrubbing and washing, magnetic separation, and . to warrant a capital-intensive beneficiation plant, which usually requires a large.\nThe Project involves establishment of a new bauxite mine capable .. Tailings. Pipeline. Sewage. Treatment. Plant. Light. Vehicle. Wash. Sediment. Pond. Power.\nBauxite is the ore most commonly mined for aluminium in which aluminium occurs as .. Other bauxite is beneficiated after crushing by washing to remove some of the . forms or fabricating plants may convert them into large structural shapes.\nTurnkey solutions for bauxite ore processing plants are offered by Star Trace. .. Experts in Sand washing plant project supply, we offer turnkey solutions to our.\nApr 11, 2016 . The separation of the alumina from the impurities in the bauxite ore is . of bauxite in the sodium aluminate liquor,; separation and washing of the . One large alumina plant employing this modified Bayer Process has two.", "domain": "chemistry", "round": 3} +{"url": "https://www.hindawi.com/journals/jnm/2013/730952/ref/", "date": "2017-02-19T21:32:57Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-09/segments/1487501170253.67/warc/CC-MAIN-20170219104610-00324-ip-10-171-10-108.ec2.internal.warc.gz", "language_score": 0.7415227890014648, "token_count": 1918, "dump": "CC-MAIN-2017-09", "global_id": "webtext-fineweb__CC-MAIN-2017-09__0__181289129", "lang": "en", "text": "- About this Journal ·\n- Abstracting and Indexing ·\n- Aims and Scope ·\n- Annual Issues ·\n- Article Processing Charges ·\n- Articles in Press ·\n- Author Guidelines ·\n- Bibliographic Information ·\n- Citations to this Journal ·\n- Contact Information ·\n- Editorial Board ·\n- Editorial Workflow ·\n- Free eTOC Alerts ·\n- Publication Ethics ·\n- Reviewers Acknowledgment ·\n- Submit a Manuscript ·\n- Subscription Information ·\n- Table of Contents\nJournal of Nanomaterials\nVolume 2013 (2013), Article ID 730952, 5 pages\nGrowth of Carbon Nanotubes on Carbon/Cobalt Films with Different sp2/sp3 Ratios\n1School of Electrical and Electronic Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798\n2Temasek Laboratories@NTU, 50 Nanyang Avenue, Singapore 639798\n3GLOBALFOUNDRIES Singapore Pte. Ltd., Singapore 738406\nReceived 10 May 2013; Accepted 7 June 2013\nAcademic Editor: Xingbin Yan\nCopyright © 2013 Naiyun Xu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.\n- V. N. Popov, “Carbon nanotubes: properties and application,” Materials Science and Engineering R, vol. 43, no. 3, 2004.\n- D. J. Yang, Q. Zhang, G. Chen, S. F. Yoon, J. Ahn, S. G. Wang, et al., “Thermal conductivity of multiwalled carbon nanotubes,” Physical Review B, vol. 66, Article ID 165440, 6 pages, 2002.\n- S. Ciraci, S. Dag, T. Yildirim, O. Gülseren, and R. T. Senger, “Functionalized carbon nanotubes and device applications,” Journal of Physics Condensed Matter, vol. 16, no. 29, pp. R901–R960, 2004.\n- K. P. Yung, J. Wei, and B. K. Tay, “Formation and assembly of carbon nanotube bumps for interconnection applications,” Diamond and Related Materials, vol. 18, no. 9, pp. 1109–1113, 2009.\n- C. P. Deck and K. Vecchio, “Prediction of carbon nanotube growth success by the analysis of carbon-catalyst binary phase diagrams,” Carbon, vol. 44, no. 2, pp. 267–275, 2006.\n- C. C. Yap, D. Tan, C. Brun et al., “Impact of the CNT growth process on gold metallization dedicated to RF interconnect applications,” International Journal of Microwave and Wireless Technologies, vol. 2, no. 5, pp. 463–469, 2010.\n- Y. B. Zhang, S. P. Lau, L. Huang, and B. K. Tay, “Carbon nanotubes grown on cobalt-containing amorphous carbon composite films,” Diamond and Related Materials, vol. 15, no. 1, pp. 171–175, 2006.\n- Y. Awano, S. Sato, M. Nihei, T. Sakai, Y. Ohno, and T. Mizutani, “Carbon nanotubes for VLSI: interconnect and transistor applications,” Proceedings of the IEEE, vol. 98, no. 12, pp. 2015–2031, 2010.\n- P. Zhang, B. K. Tay, and S. P. Lau, “Rapid thermal annealing study on the metal containing amorphous carbon films,” Diamond and Related Materials, vol. 12, no. 10-11, pp. 2093–2098, 2003.\n- A. T. T. Koh, J. Hsieh, and D. H. C. Chua, “Electron emission studies of CNTs grown on Ti and Ni containing amorphous carbon nanocomposite films,” Applied Surface Science, vol. 256, no. 1, pp. 178–182, 2009.\n- T. Takeno, H. Miki, T. Takagi, and H. Onodera, “Electrically conductive properties of tungsten-containing diamond-like carbon films,” Diamond and Related Materials, vol. 15, no. 11-12, pp. 1902–1905, 2006.\n- S. Sansongsiri, A. Anders, and B. Yotsombat, “Electrical properties of a-C: mo films produced by dual-cathode filtered cathodic arc plasma deposition,” Diamond and Related Materials, vol. 17, no. 12, pp. 2080–2083, 2008.\n- J. L. Endrino, D. Horwat, R. Gago et al., “Electronic structure and conductivity of nanocomposite metal (Au, Ag, Cu, Mo)-containing amorphous carbon films,” Solid State Sciences, vol. 11, no. 10, pp. 1742–1746, 2009.\n- N. Xu, H. T. E. Teo, M. Shakerzadeh, X. Wang, C. M. Ng, and B. K. Tay, “Electrical properties of textured carbon film formed by pulsed laser annealing,” Diamond and Related Materials, vol. 23, pp. 135–139, 2012.\n- C. W. Tan, S. Maziar, E. H. T. Teo, and B. K. Tay, “Microstructure and through-film electrical characteristics of vertically aligned amorphous carbon films,” Diamond and Related Materials, vol. 20, no. 3, pp. 290–293, 2011.\n- M. Shakerzadeh, N. Xu, M. Bosman et al., “Field emission enhancement and microstructural changes of carbon films by single pulse laser irradiation,” Carbon, vol. 49, no. 3, pp. 1018–1024, 2011.\n- D. W. M. Lau, D. G. McCulloch, M. B. Taylor et al., “Abrupt stress induced transformation in amorphous carbon films with a highly conductive transition phase,” Physical Review Letters, vol. 100, no. 17, Article ID 176101, 2008.\n- N. Y. Xu, H. T. Teo, X. C. Wang, A. Y. Du, C. M. Ng, and B. K. Tay, “Carbon metal composite film deposited using novel filtered cathodic vacuum arc technique,” in Proceedings of the 61st Electronic Components and Technology Conference (ECTC '11), pp. 1234–1238, June 2011.\n- J. Robertson, “Diamond-like amorphous carbon,” Materials Science & Engineering, vol. 37, no. 4–6, pp. 129–281, 2002.\n- A. C. Ferrari and J. Robertson, “Interpretation of Raman spectra of disordered and amorphous carbon,” Physical Review B, vol. 61, no. 20, pp. 14095–14107, 2000.\n- G. Abrasonis, M. Krause, A. Mücklich, K. Sedlacková, G. Radnóczi, U. Kreissig, et al., “Growth regimes and metal enhanced 6-fold ring clustering of carbon in carbon-nickel composite thin films,” Carbon, vol. 45, no. 15, pp. 2995–3006, 2007.\n- K. D. G. I. Jayawardena, Y. Y. Tan, J. Fryar et al., “Highly conductive nanoclustered carbon:nickel films grown by pulsed laser deposition,” Carbon, vol. 49, no. 12, pp. 3781–3788, 2011.\n- M. S. Dresselhaus, G. Dresselhaus, R. Saito, and A. Jorio, “Raman spectroscopy of carbon nanotubes,” Physics Reports, vol. 409, no. 2, pp. 47–99, 2005.\n- X. Sun, K. Li, R. Wu et al., “The effect of catalysts and underlayer metals on the properties of PECVD-grown carbon nanostructures,” Nanotechnology, vol. 21, no. 4, Article ID 045201, 2010.", "domain": "chemistry", "round": 3} +{"url": "https://www.sae.org/publications/technical-papers/content/932739/", "date": "2019-02-20T23:25:08Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-09/segments/1550247496855.63/warc/CC-MAIN-20190220230820-20190221012820-00027.warc.gz", "language_score": 0.8686891198158264, "token_count": 340, "dump": "CC-MAIN-2019-09", "global_id": "webtext-fineweb__CC-MAIN-2019-09__0__39925268", "lang": "en", "text": "Diesel Additive Technology Effects on Injector Hole Erosion/Corrosion, Injector Fouling and Particulate Traps 932739\nFuel additives can contribute to maintaining the performance of diesel engines in a variety of ways. This holds true for current and future engine technology.\nFouling of indirect injection engines (IDI) has been studied at length. Fouling of direct injection engines (Dl) is less known and less well understood. Problems associated with Dl fouling and a proposed mechanism for it are discussed. Additive effectiveness in preventing injector fouling is confirmed.\nInjector hole corrosion/erosion, as experienced in the Cummins N14 engine, can be avoided by the appropriate additive chemistry.\nParticulate traps can also benefit from ashless additive technology aimed at increasing the time between regeneration steps, hence improving effective trap life.\nCitation: Caprotti, R., Fowler, W., Lepperhoff, G., and Houben, M., \"Diesel Additive Technology Effects on Injector Hole Erosion/Corrosion, Injector Fouling and Particulate Traps,\" SAE Technical Paper 932739, 1993, https://doi.org/10.4271/932739. Download Citation\nR. Caprotti, W. J. Fowler, G. Lepperhoff, M. Houben\nExxon Chemical, FEV Motorentechnik\nInternational Fuels & Lubricants Meeting & Exposition\nDiesel Fuels for the Nineties: Composition and Additives to Meet Emissions and Performance Needs-SP-0994", "domain": "chemistry", "round": 3} +{"url": "http://oca.weizmann.ac.il/pmbin/getpm?pmid=21240271", "date": "2022-09-28T11:39:58Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-40/segments/1664030335254.72/warc/CC-MAIN-20220928113848-20220928143848-00392.warc.gz", "language_score": 0.8529276847839355, "token_count": 427, "dump": "CC-MAIN-2022-40", "global_id": "webtext-fineweb__CC-MAIN-2022-40__0__280749143", "lang": "en", "text": "- Hausmann J, Kamtekar S, Christodoulou E, Day JE, Wu T, Fulkerson Z, Albers HM, van Meeteren LA, Houben AJ, van Zeijl L, Jansen S, Andries M, Hall T, Pegg LE, Benson TE, Kasiem M, Harlos K, Kooi CW, Smyth SS, Ovaa H, Bollen M, Morris AJ, Moolenaar WH, Perrakis A\n- Structural basis of substrate discrimination and integrin binding by autotaxin.\n- Nat Struct Mol Biol. 2011 Feb;18(2):198-204. Epub 2011 Jan 16.\n- Autotaxin (ATX, also known as ectonucleotide pyrophosphatase/phosphodiesterase-2, ENPP2) is a secreted lysophospholipase D that generates the lipid mediator lysophosphatidic acid (LPA), a mitogen and chemoattractant for many cell types. ATX-LPA signaling is involved in various pathologies including tumor progression and inflammation. However, the molecular basis of substrate recognition and catalysis by ATX and the mechanism by which it interacts with target cells are unclear. Here, we present the crystal structure of ATX, alone and in complex with a small-molecule inhibitor. We have identified a hydrophobic lipid-binding pocket and mapped key residues for catalysis and selection between nucleotide and phospholipid substrates. We have shown that ATX interacts with cell-surface integrins through its N-terminal somatomedin B-like domains, using an atypical mechanism. Our results define determinants of substrate discrimination by the ENPP family, suggest how ATX promotes localized LPA signaling and suggest new approaches for targeting ATX with small-molecule therapeutic agents.", "domain": "chemistry", "round": 3} +{"url": "https://www.genetex.com/Product/Detail/ADAM10-antibody-N2C1-Internal/GTX104940", "date": "2019-02-20T05:04:57Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-09/segments/1550247494449.56/warc/CC-MAIN-20190220044622-20190220070622-00093.warc.gz", "language_score": 0.7622016072273254, "token_count": 562, "dump": "CC-MAIN-2019-09", "global_id": "webtext-fineweb__CC-MAIN-2019-09__0__145436715", "lang": "en", "text": "*Optimal dilutions/concentrations should be determined by the researcher.\nNot tested in other applications.\nMouse, Rat, Bovine, Chicken, Pig, Xenopus laevis(>80% identity)\n0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.\nStore as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.\n0.48mg/ml(Please refer to the vial label for the specific concentration.)\nRecombinant protein encompassing a sequence within the center region of human ADAM10. The exact sequence is proprietary.\nPurified by antigen-affinity chromatography.\nFor laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.\nAD10 antibody, CD156c antibody, HsT18717 antibody, MADM antibody, kuz antibody, ADAM10 antibody, mammalian disintegrin-metalloprotease antibody, a disintegrin and metalloproteinase domain 10 antibody, kuzbanian protein homolog antibody, CDw156 antibody, disintegrin and metalloproteinase domain-containing protein 10 antibody, ADAM 10 antibody, a disintegrin and metalloprotease domain 10 antibody, ADAM metallopeptidase domain 10 antibody\nCell membrane , Endomembrane system\nMembers of the ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains. This gene encodes and ADAM family member that cleaves many proteins including TNF-alpha and E-cadherin. [provided by RefSeq]\nGTX104940 IHC-P Image\nImmunohistochemical analysis of paraffin-embedded human lung Papillary adenocarcinoma, using ADAM10(GTX104940) antibody at 1:250 dilution.\nAntigen Retrieval: Trilogy™ (EDTA based, pH 8.0) buffer, 15min\nGTX104940 WB Image\nSample (30 µg of whole cell lysate)\n7.5% SDS PAGE\nGTX104940 diluted at 1:1000\nThe HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.", "domain": "chemistry", "round": 3} +{"url": "https://bv.fapesp.br/en/bolsas/133915/sources-and-way-of-boron-application-in-eucalyptus-crop/", "date": "2022-12-04T15:57:53Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-49/segments/1669446710974.36/warc/CC-MAIN-20221204140455-20221204170455-00524.warc.gz", "language_score": 0.9590396285057068, "token_count": 347, "dump": "CC-MAIN-2022-49", "global_id": "webtext-fineweb__CC-MAIN-2022-49__0__70786619", "lang": "en", "text": "The application of fertilizers is essential to supply the demands of eucalyptus, mainly in Cerrado soils. In addition to NPK fertilization, some species of eucalyptus are demanding in some micronutrients such as B for its development. Therefore, studies on the amounts of macro and micronutrients are important to determine the optimal amounts of these nutrients and economically viable in forest species. The objective is to compare the effect of sources of boron with high and low solubility in the Eucalyptus spp crop, besides application on leaf using boric acid. The experiment is being conducted on the farm Renascença, fund managed by Cargill Agricola S / A, located in Selvíria - MS. The experimental design is a randomized block with six treatments and five replications in a factorial 3 x 2, constituted by: 0 kg ha-1 of boron, 1 kg ha-1 of boron using boric acid as a source (high solubility, 17%) and 1 kg ha-1 of boron using borogran as source (low solubility, 10% ), which were applied in the furrow, besides absence or presence of boric acid at leaf. All treatments were fertilized with NPK formulation. The experiment is being conducted since January 2012 when it was performed the implantation of the crop planting and fertilization. Will be done the following assessments: leaf analysis, plant height, diameter at 30 cm or at breast height, total volume of wood with bark and mean annual increment.\nNews published in Agência FAPESP Newsletter about the scholarship:", "domain": "chemistry", "round": 3} +{"url": "https://works.bepress.com/abukasim_nh/7/", "date": "2018-07-22T20:54:26Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-30/segments/1531676593586.54/warc/CC-MAIN-20180722194125-20180722214125-00051.warc.gz", "language_score": 0.8731602430343628, "token_count": 582, "dump": "CC-MAIN-2018-30", "global_id": "webtext-fineweb__CC-MAIN-2018-30__0__41475552", "lang": "en", "text": "Introduction: Owing to the variety of materials and methods employed, comparison of the results and findings from bonding studies is difficult. Until recently, several types of teeth have been used in published research papers as a substrate in orthodontic bonding research including bovine incisors, fresh and rebonded human premolars. Objectives: The purpose of this study was to compare the shear bond strength of an adhesive bonded to different tooth surfaces (human premolar, bovine incisor and rebonded human premolar). Methods: Two groups of thirty premolar teeth and one group of bovine incisors had brackets attached in a standardized manner using Transbond XT (3M Unitek). The adhesive was cured using conventional halogen light and a specially designed tool to standardize the distance between the light curing tip and the adhesive. The debonding force was measured using Instron universal testing machine. ANOVA and Post Hoc Dunnett C test were performed to determine any significant difference among groups (p<0.05). Results: The results of Post Hoc Dunnett C test indicated no statistical differences between the human premolar group and rebonded group. However, the differences existed in bond strength between bovine group versus human premolar group and bovine group versus human rebonded premolar group. Bovine group had the highest bond strength with mean values of 8.5 (S.D ± 4.2) MPa. Human premolar and rebonded groups had mean bond strengths of 6.1(S.D ± 4.5) and 4.9 (S.D ± 2.7) MPa, respectively. Conclusions: This study revealed that bovine teeth produced higher bond strength compared to b o t h f r e s h a n d re b o n d e d h u m a n p r e m o l a r. Therefore, findings in any bond strength studies u s i n g b ovi n e t e e t h s h o u l d b e i n t e r p re t e d wi t h caution.\n- Orthodontic adhesives; bond strength; human premolar; bovine tooth; SELF-REPAIR; CULTURE-CONDITIONS; COMPOSITE RESIN; DENTAL PULP STEM CELL; FUNCTIONALLY GRADED DESIGN; MULTI LAYERED POST; FUNCTIONALLY GRADED DENTAL POST; SOFT SKILLS; CLINICAL PAIRING; DENTAL PULP STROMAL CELLS; LONG-TERM EXPANSION\nAvailable at: http://works.bepress.com/abukasim_nh/7/", "domain": "chemistry", "round": 3} +{"url": "http://www.scottishschools.info/Duncanrig/TextList/TextListContent.aspx?TextListContentId=2cc44ec7-4c83-4779-a48d-b4a7c5b83330&SectionId=7a9c4596-01d9-4c6f-a741-b4e4f9c0e085", "date": "2013-12-06T01:36:44Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2013-48/segments/1386163048970/warc/CC-MAIN-20131204131728-00022-ip-10-33-133-15.ec2.internal.warc.gz", "language_score": 0.9492082595825195, "token_count": 426, "dump": "CC-MAIN-2013-48", "global_id": "webtext-fineweb__CC-MAIN-2013-48__0__101127562", "lang": "en", "text": "Chemistry is the study of substances, what they’re made of, how they interact and what role they play in living things. In fact, it’s the study of all materials and is vital to every aspect of our lives. Not surprisingly, careers in Chemistry are exciting and enjoyable with lots of variety and opportunities.\nChemistry is often called the central science. It links with all the other sciences and has links with many branches of technology from the silicon chip to brewing.\nThe S2 course in Chemistry allows pupils to begin a programme of study in Chemistry leading initially to courses at Standard Grade or Intermediate 1 level in S3 and S4, with the possibility of further study at Higher or Intermediate 2 level in the upper school. Some students progress to Advanced Higher in S6.\nIntermediate 1 Chemistry\nThis course is offered as an alternative programme of study in Chemistry to students in the middle school. It is aimed mainly at less able students who wish to continue to study Chemistry, but for whom Standard Grade might not be the most appropriate course. The course is undertaken on a 3 period per week basis over the 2 years of S3 and S4.\nIntermediate 2 Chemistry\nThis course is offered as an alternative course to Higher Chemistry in S5. Students who wish to continue their Chemistry studies but who feel the big step to Higher may be too challenging often find this course an excellent stepping stone to studying Higher in S6.\nOur course covers the three units as described in the Scottish Qualifications Authority (SQA) “National Course Specification, 5th\nEdition (June 2002)” and available online at www.sqa.org.uk\nAdvanced Higher Chemistry\nCourse materials used are from the series of Advanced Higher Chemistry titles produced by the Higher Still support programme for Chemistry and published by Learning and Teaching Scotland 2000.\nA Chemical Investigation is usually carried out concurrently with the teaching of course work and normally would be completed in a period after Christmas.\nIn addition Advanced Higher students complete a range of prescribed practical activities throughout the course.\n<< Back to Subjects", "domain": "chemistry", "round": 3} +{"url": "http://jnessayejha.clinchrivertitle.com/nanocomposite-thesis.html", "date": "2017-08-16T19:33:32Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-34/segments/1502886102393.60/warc/CC-MAIN-20170816191044-20170816211044-00078.warc.gz", "language_score": 0.7959098815917969, "token_count": 1730, "dump": "CC-MAIN-2017-34", "global_id": "webtext-fineweb__CC-MAIN-2017-34__0__28943040", "lang": "en", "text": "Characterization of Activated Carbon particles for nanocomposite synthesis. L.P. Terrazas-Bandala*, E.A. Zaragoza-Contreras*, G. González-Sánchez*, M.L. Ballinas. Senior Theses. written by students associated with the Ceramic Materials Laboratory. Thesis number assigned by Mudd Manuscript Library, Princeton University. Thesis. Degree Name. Master of Science The proposed system of polyurethane nanocomposite foam offers a potential for the removal of arsenic with higher. DESIGN TOOL FOR SIMULATION OF NANOCOMPOSITE MATERIAL PROPERTIES A Thesis Presented to The Academic Faculty by Johnny Lee Worthy III In Partial Fulfillment. Improvement that the graphene–polymer nanocomposite is able to provide.5 Despite the differences in structure between GO and graphene, incorporation of GO into polymer. Production and characterization of nanocomposite materials from recycled thermoplastics a thesis submitted to the graduate school of natural and applied. AN ABSTRACT OF THE THESIS OF Jin Zeng for the degree of Master of Science in Materials Science presented on June 17, 2009. Title: An Experimental Study on.\nSTUDY OF EXTRUSION OF POLYSTYRENE NANOCOMPOSITE FOAMS WITH SUPERCRITICAL CARBON DIOXIDE Senior Honors Thesis by Shah, Jay Date. POLYMER NANOCOMPOSITES ARE THE FUTURE ALYSSA DOWNING-PERRAULT. Advantages of nanocomposite films are numerous and the possibilities for. Graduate Theses and Dissertations Graduate College 2012 Synthesis and characterization of mesoporous zirconia nanocomposite using self-assembled block. BIODEGRADABLE HYDROGELS AND NANOCOMPOSITE POLYMERS:. I represent that my thesis or dissertation and abstract are my original work. Proper attribution. Nanocomposite of ZrO2/Polymer Thin-Film Coatings by The Ionically Self-Assembled Monolayer Technique by Aprillya Rosidian Thesis submitted to the Faculty of the. A thesis submitted to the Graduate Faculty of. Auburn University be provided in a 2-D nanocomposite matrix. As the reaction media, four different noble metal. Recent Graduate Student Thesis Titles Understanding the Process Structure Property Relationship in Biodegradable Polymer Nanocomposite. non-thesis: Dickson. Characterization of Electrosprayed Poly(vinylidene fluoride) and Poly(vinylidene fluoride)/CNT Nanocomposite A thesis submitted in partial fulfillment of the.\nMORPHOLOGY AND MECHANICAL PROPERTIES OF POLYSULFONE/POLYIMIDE NANOCOMPOSITE FILMS. A Thesis. Presented to. The Graduate Faculty of The. Vivek Tomer, Ph.D. thesis (2006-2010, defended: May 7, 2010). Polymer Nanocomposite Technology, Fundamentals of Barrier TAPPI-2oo9: Flexible. Polymer nanocomposite. This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Page 1 1 a molecular dynamics study on cellulose fiber reinforced nanocomposite by shi li a thesis presented to the graduate school of the university of florida in. MONTMORILLONITE CLAY AND EPOXY NANOCOMPOSITE Peter Robert Butzloff, B.S. Thesis Prepared for the Degree of MASTER OF SCIENCE UNIVERSITY OF NORTH. The Development of a CFD Program to Model the Pressure Distribution of a Nanocomposite Melt Flow through a Twin-Screw Extruder Craig Lewandowski. PEG-Mn3O4 Nanocomposite E. Karaoˇglu1. thesis todecreasethe surfaceenergy, controlthe growth and shape of the particles, and act against aggregation .\nSimulation of Thermal Transport in a Nanocomposite Blow Mold A thesis presented to the faculty of the Russ College of Engineering and Technology of Ohio University. Cataloged from PDF version of thesis. In title. All the nanocomposite samples in this thesis are made solely for research uses and are purposely. FINITE ELEMENT ANALYSIS OF THREE-PHASE PIEZOELECTRIC NANOCOMPOSITES A Thesis by KEVIN S. MAXWELL Submitted to the O–ce of Graduate Studies of Texas. Thesis (Ph. D. Thermoelectric materials have attractive applications in electric power. We pursue the nanocomposite approach as an alternative to superlattices. SYNTHESIS AND PERFORMANCE ANALYSIS OF POLYURETHANE FOAM NANOCOMPOSITE FOR ARSENIC REMOVAL FROM DRINKING WATER by Faten Bakri Hussein A Thesis.\nSynthesis of multimetallic nanocomposite materials utilizing block copolymers. Page 1 Previous: 1 of 207: Next : View Description. View PDF & Text : Download: small. High demand exists for magnetically tunable nanocomposite materials. My thesis focuses on synthesis and characterization of novel nanomaterials such as polymer. In this thesis, piezoresistive thin film devices made of carbon nanotube (CNT)-polyimide (PI) nanocomposite were fabricated and characterized. Ii EPOXY/SINGLE WALLED CARBON NANOTUBE NANOCOMPOSITE THIN FILMS FOR COMPOSITES REINFORCEMENT A Thesis by GRAHAM LEICESTER WARREN. I IMPROVEMENT OF A CONSTITUTIVE MODEL FOR PREDICTING FLOW BEHAVIOR OF NANOCOMPOSITES Undergraduate Research Thesis Presented in Partial Fulfillment. The effect of shear force on microstructure and mechanical property of epoxy/clay nanocomposite by tak-keun oh a thesis presented to the graduate school. Thesis. Degree Name. Master of Science The proposed system of polyurethane nanocomposite foam offers a potential for the removal of arsenic with higher.\nElectronic Theses and Dissertations Masters Thesis. Processing and Characterization of Polymer Derived Ceramic Nanocomposite Coating Reinforced with Carbon Nanotube. Synthesis of Aluminum-Aluminum Nitride Nanocomposites by Gas-Liquid Reactions by Cecilia Borgonovo A Thesis Submitted to the Faculty of WORCESTER POLYTECHNIC. Polymer / Sepiolite Clay Nanocomposites. A THESIS SUBMITTED TO THE UNIVERSITY OF LONDON FOR THE DEGREE OF DOCTOR OF PHILOSOPHY February 2009 By. SYNTHESIS, CHARACTERIZATION AND TRIBOLOGICAL BEHAVIOR OF NITROGEN-DOPED CHROMIUM-DIAMOND-LIKE CARBON NANOCOMPOSITE THIN FILMS A Thesis.\nPhd Thesis Polymer Nanocomposites Electrical Properties of Graphene Polymer Nanocomposites 27 superior electron transport characteristics are always. Synthesis and Characterization of Neem Chitosan Nanocomposites for Development of Antimicrobial Cotton Textiles Rajendran R. Ph.D. 1, Radhai R. . Recommended Citation. Ge, Qinwen, \"Synthesis and characterization of mesoporous zirconia nanocomposite using self-assembled block copolymer template\" (2012). Western Michigan University ScholarWorks at WMU Dissertations Graduate College 12-2009 Simulation, Synthesis, and Characterization of Hydrogels and Nanocomposite. BACTERIAL CELLULOSE/THERMOPLASTIC POLYMER NANOCOMPOSITES By ELVIE ESCORRO BROWN A thesis submitted in partial fulfillment of the. Thesis 1 - Free download as PDF File (.pdf), Text File (.txt) or read online for free.", "domain": "chemistry", "round": 3} +{"url": "https://priceritemart.com.au/products/guerlain-vetiver-new-packaging-100ml-edt-m-sp", "date": "2023-12-06T21:39:42Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100603.33/warc/CC-MAIN-20231206194439-20231206224439-00395.warc.gz", "language_score": 0.6721199154853821, "token_count": 258, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__180012956", "lang": "en", "text": "Guerlain Vetiver (New Packaging) 100ml EDT (M) SP\nThe bottle was changed and the color of the perfume, but the fragrance remained gorgeous, just like before. The top notes are bergamot, coriander, lemon, mandarin, and neroli; the heart unites vetiver and cedar wood; the base is composed of tobacco, walnuts, pepper, and Tonka bean.\nINGREDIENTS: ALCOHOL DENAT., AQUA/WATER/EAU, PARFUM/FRAGRANCE, METHYL CYCLODEXTRIN, ETHYLHEXYL SALICYLATE, LIMONENE, BUTYL METHOXYDIBENZOYLMETHANE, LINALOOL, CITRAL, ALCOHOL, TRIS(TETRAMETHYLHYDROXYPIPERIDINOL) CITRATE, FARNESOL, TETRASODIUM GLUTAMATE DIACETATE, EXT. D&C VIOLET NO. 2 (CI 60730), FD&C BLUE NO. 1 (CI 42090), FD&C RED NO. 4 (CI 14700).", "domain": "chemistry", "round": 3} +{"url": "https://www.ifum.uni-hannover.de/2058.html?no_cache=1&tx_tkpublikationen_pi1%5BshowUid%5D=67112", "date": "2019-08-26T02:35:52Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-35/segments/1566027330962.67/warc/CC-MAIN-20190826022215-20190826044215-00376.warc.gz", "language_score": 0.8885571360588074, "token_count": 385, "dump": "CC-MAIN-2019-35", "global_id": "webtext-fineweb__CC-MAIN-2019-35__0__115864190", "lang": "en", "text": "Fracture resistance evaluation of RuO2-based thick film resistor material by in situ crack extension observation in a scanning electron microscope\n|Autoren:||Dorsch, N. S.; Peshekhodov, I.; Spies, P.; Schneider, G. A.|\n|Veröffentlichung:||ISSN 1359-6454, Acta Materialia, Volume 56, Issue 18, October 2008, pp. 5027-5033|\nParameters for the fracture mechanics of thick film materials are scarce in the literature. One reason is that for many such materials it is very difficult to produce a bulk specimen as required for most standard tests. This paper describes an alternative method for measuring the fracture resistance of a ruthenium dioxide (RuO2)-based thick film resistor material for electronic applications. The method is based on an in situ investigation of crack propagation in the loaded material. The investigated material is printed as a thick film on a substrate of low-temperature-co-fired-ceramic. An initial crack in the film is introduced with a Vickers indenter. The crack is subsequently loaded with a four-point bending equipment in a scanning electron microscope, which allows for in situ crack length measurement. The crack growth measurements reveal that once a certain crack length is achieved the load required to extend the crack becomes independent of the crack length. Beyond this length, the crack propagates in the so-called steady-state region, which is used in the present method to estimate the fracture resistance of the film. Both tensile stresses resulting from bending and tensile residual stresses are taken into account. Although a brittle substrate was used, the crack did not penetrate into the substrate. The measured fracture resistance of 0.69 ± 0.14 MPa√m is found to be realistic for the investigated thick film material with high silicate glass content.", "domain": "chemistry", "round": 3} +{"url": "http://www.bioresearchonline.com/doc/MODcol-Multipacker-Technical-Poster-0001", "date": "2013-05-23T00:54:24Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2013-20/segments/1368702718570/warc/CC-MAIN-20130516111158-00065-ip-10-60-113-184.ec2.internal.warc.gz", "language_score": 0.8826705813407898, "token_count": 434, "dump": "CC-MAIN-2013-20", "global_id": "webtext-fineweb__CC-MAIN-2013-20__0__146725689", "lang": "en", "text": "MODcol® Multipacker® Technical PosterSource: Grace\nBy Reno Nguyen, Jochen Saar and Theresa Riley\nOne of the challenges in scaling up chromatography processes from analytical method development to pilot or production scale is optimizing the column packing procedure. Early method development work is typically done on pre-packed columns supplied from HPLC stationary phase manufacturers. However, for performance, economic, availability, and simple logistics issues most users migrate to dynamic axial compression (DAC) columns that are packed in-house once processes require large i.d. columns, >100mm i.d. Chromatographers experience numerous difficulties packing stable beds in process/production columns. These problems include non-uniform compression, bed deformation, channeling, void formation and crushing under improper packing. The use of true dynamic axial compression can overcome these issues and produce high quality beds that will exhibit high performance over a broad range of flow rates as evidenced by HETP (height per each theoretical plate) test. Placing constant pressure on a moveable piston gives it the dynamic capability of maintaining a consistent homogeneous bed. The resulting elimination of voids and channeling provides ultimate chromatographic performance. While stationary phase manufacturers may give guidance on packing procedures for their phases, end users often must engage in a trial and error process to determine how best to pack an HPLC phase using their individual DAC system, often sacrificing valuable product in the process. Here we outline a method for optimizing DAC packing using the MODcol® MultiPacker® columns for various HPLC phases including polymer resins, 300Å silica phases, 120Å silica phases, and irregular 60Å and 500Å silica. The availability of smaller i.d. DAC columns with the MODcol® system helps allow users to lock-in scaleable packing processes early in development to further minimize risk involved in scale-up. The Spring® column's main feature is the presence of a set of Belleville washers which provides constant pressure on the resin bed. Examples are given for DAC columns ranging from 25mm i.d. to 101mm i.d.", "domain": "chemistry", "round": 3} +{"url": "https://www.peptide-powder.com/sale-14160478-healthcare-white-powder-somatropin-peptide-hgh-191aa-10-vials-box.html", "date": "2023-03-29T04:36:42Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-14/segments/1679296948932.75/warc/CC-MAIN-20230329023546-20230329053546-00033.warc.gz", "language_score": 0.7447242736816406, "token_count": 861, "dump": "CC-MAIN-2023-14", "global_id": "webtext-fineweb__CC-MAIN-2023-14__0__141158058", "lang": "en", "text": "|Place of Origin:||China|\n|Certification:||COA, HPLC MR|\n|Model Number:||HBY-HGH 191aa|\n|Minimum Order Quantity:||1 BOX|\n|Packaging Details:||10iu/vial, 10vials/box|\n|Delivery Time:||3-5 work days after your payment|\n|Payment Terms:||MoneyGram, Western Union, T/T|\n|Product Name:||HGH Paper Boxes For 10iu/Vial Somatotropin Human Growth Hormone 191AA||Other Name:||Hgh Growth Hormone|\n|Cas:||12629-01-5||Certification:||COA, HPLC MR|\n10 Vials/box HGH 191aa Peptide,\nHealthcare HGH 191aa Peptide,\nwhite powder somatropin 191aa 10iu\nWhat is HGH Paper Boxes for 10iu/Vial Somatotropin Human Growth Hormone 191AA?\nHGH 191AA is the anterior pituitary growth hormone (HGH), growth hormone (HGH 191aa) containing eosinophilic granular secretory cells secrete, consisting of hgh 191aa amino acid peptide hormone.This product is made by genotype secretion of recombinante. coli expression technology in the production of recombinant human growth hormone (HGH 191aa), the amino acid content and sequence of growth hormone are exactly the same with people.This product is in escherichia coli (e.c. with our fabrication: oli) in the composite.Synthesis was conducted by former hormone (prehormone).The former hormone is by nature exists in bacteria, growth hormone, which is connected with signal peptide.Hormone split in the bacterial cell wall, before release and natural growth hormone is exactly the same end products into the wall of the intermembrane space, and then destroy the cell walls to collect, only the intact cell wall, to ensure the end products rarely bacterial protein pollution.\n|Product Name||HGH Paper Boxes for 10iu/Vial Somatotropin Human Growth Hormone 191AA|\n|Shelf Life||2 years|\nApplication of HGH Paper Boxes for 10iu/Vial Somatotropin Human Growth Hormone 191AA:\nFunction of HGH Paper Boxes for 10iu/Vial Somatotropin Human Growth Hormone 191AA:\nPackage and Shipping of HGH Paper Boxes for 10iu/Vial Somatotropin Human Growth Hormone 191AA:\nWith 3-5 work days, after your payment.\nFAQ of HGH Paper Boxes for 10iu/Vial Somatotropin Human Growth Hormone 191AA:\nQ1: Do you Accept Sample Order?\nA: Yes. The smallest order we accept is 20g.\nQ2: Do you accept VISA business credit card?\nA: Yes. VISA business credit card is in our payment .\nQ3: Is there any discount?\nA: Yes, if you want to purchase larger quantity, we can offer better price fpr you.\nQ4: How long does it take to me if I order?\nA: About 3-5 days upon recepient of payment.\nQ5: What kind of transportation do you have?\nA: We have many ways of transportations, eg: Air, Sea, Special Lines,TNT, FEDEX, EMS, ect.", "domain": "chemistry", "round": 3} +{"url": "https://books.rsc.org/books/edited-volume/545/chapter-abstract/194830/Methods-of-Peroxynitrite-Synthesis-in-the-Context?redirectedFrom=fulltext", "date": "2023-10-01T19:21:20Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233510924.74/warc/CC-MAIN-20231001173415-20231001203415-00660.warc.gz", "language_score": 0.8830079436302185, "token_count": 377, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__180132373", "lang": "en", "text": "Peroxynitrite Detection in Biological Media: Challenges and Advances\nCHAPTER 3: Methods of Peroxynitrite Synthesis in the Context of the Development and Validation of Peroxynitrite Sensors\nPublished:16 Oct 2015\nM. Bayachou, G. Altawallbeh, H. Kalil, S. Wojciechowski, and T. Bose, in Peroxynitrite Detection in Biological Media: Challenges and Advances, ed. S. Peteu, S. Szunerits, and M. Bayachou, The Royal Society of Chemistry, 2015, pp. 48-62.\nDownload citation file:\nPeroxynitrite has emerged as a major cytotoxic agent implicated in a host of pathophysiological conditions triggered by its multifaceted nitroxidative reactions. Peroxynitrite's very short half-life under physiological conditions reflects both its fast intrinsic decomposition and its notorious reactivity with many cellular targets. Sensitive and accurate measurement of peroxynitrite is crucial to investigations that aim at shedding light on the illusive pathophysiologic roles of this metabolite. The development process of probes and sensors capable of selectively detecting and measuring any analyte depends primarily on the availability of pure authentic amounts of it in order to evaluate sensor performance. There are numerous methods of peroxynitrite synthesis or generation in situ. However, they all come with varying levels of byproducts that may interfere with the characterization of performance of peroxynitrite sensing probes and devices. This chapter gives the background and a brief review of major methods of peroxynitrite synthesis and in situ generation. Particularly, we discuss advantages and drawbacks of the various methods in the context of the development and characterization of peroxynitrite sensors and probes.", "domain": "chemistry", "round": 3} +{"url": "https://www.wellnessresources.com/studies/quercetin-reduces-pain", "date": "2019-07-18T12:33:55Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-30/segments/1563195525627.38/warc/CC-MAIN-20190718104512-20190718130512-00280.warc.gz", "language_score": 0.876590371131897, "token_count": 500, "dump": "CC-MAIN-2019-30", "global_id": "webtext-fineweb__CC-MAIN-2019-30__0__195825033", "lang": "en", "text": "The antinociceptive action of quercetin, a common bioactive flavonoid present in many medicinal plants, was assessed in different models of chemical and thermal nociception in mice. Quercetin (10-60 mg/kg, i.p. or 100-500 mg/kg, p.o.) dose-dependently inhibited nociceptive behavior in the acetic acid-induced pain test. Moreover, quercetin (10-60 mg/kg, i.p.) inhibited both phases of formalin-induced pain, with ID50 values of 374.1 (68.0-402.0) mmol/kg and 103.0 (45.0-201.0) mmol/kg, for the neurogenic and inflammatory phases, respectively. Quercetin (10-60 mg/kg) also inhibited the nociception induced by glutamate and capsaicin by 68.2% and 75.5%, respectively. Its analgesic action was significantly reversed by p-chlorophenylalanine methyl ester, katanserin, methysergide, a GABA(A) antagonist (bicuculline), or a GABA(B) antagonists (baclofen). Its action was also modulated by tachykinins, but was not affected by adrenal-gland hormones. Furthermore, the antinociceptive effects did not result from muscle-relaxant or sedative action. Together, these results indicate that quercetin produces dose-related anti-nociception in several models of chemical pain, through mechanisms that involve interaction with L-arginine-nitric oxide, serotonin, and GABAergic systems. These results confirm and extend other investigations on the analgesic effect of quercetin and its mechanisms of action.\nFilho AW, Filho VC, Olinger L, de Souza MM. Quercetin: further investigation of its antinociceptive properties and mechanisms of action. Arch Pharm Res. 2008 June Programa de Mestrado em Ciências Farmacêuticas e Núcleo de Investigações Químico-Farmacêuticas (NIQFAR)/CCS, Universidade do Vale do Itajaí (UNIVALI), 88302-202, Itajaí, SC, Brazil.", "domain": "chemistry", "round": 3} +{"url": "https://www.materygraphite.com/bulletin-graphite-resillient-graphite-product/", "date": "2024-02-21T17:18:41Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707947473524.88/warc/CC-MAIN-20240221170215-20240221200215-00463.warc.gz", "language_score": 0.8831260204315186, "token_count": 422, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__165001234", "lang": "en", "text": "Graphite is a coarse-sized plugging agent used in water, oil or synthetic-based drilling fluids to bridge and seal permeable and fractured formations. When drilling depleted zones exposed to high different pressures, the bridging and plugging capabilities of GRAPHITE additive can reduce the potential for stuck pipe. Graphite is chemically inert and thermally stable, and will not affect rheological properties when used at recommended concentrations. It can lower the potential for lost circulation and reduce torque and drag in many drilling applications.\nTypical Physical Properties\nPhysical appearance：Black powder\nSpecific gravity： 2.19-2.26\nGraphite additive is designed to be used in any type of drilling fluid to bridge and seal permeable fractured formations, thus controlling lost circulation and reducing the possibility of differential sticking. Graphite can also be used to decreases the coefficient of friction (CoF) of drilling fluids. The recommended treatment for seepage losses (<10 bbl/hr or 1.6 m3/hr) is 15 to 20lb/bbl (43 to 57 kg/m3) in spotted pills or sweeps. The recommended treatment for partial losses (10 to 100 bbl/h or 1.6 to 16 m3/hr) is 20 to 50 lb/bbl (57 to 143 kg/m3) in spotted pills.\nGraphite may require additional wetting agent when used in an oil-or synthetic-based mud system.\n• Effective bridging and sealing agent for a wide range of formations severity of losses.\n• Controls seepage losses, thereby reducing the possibility of differential sticking.\n• Decreases the CoF to reduce torque and drag in all mud systems.\n• Temperature stable to more than 260o C (500oF).\n• May be used in combination with other additives, particularly lost circulation materials.\nPacking and Storage\nGRAPHITE is packaged in a 25 kg (55.1 lb), multi-wall paper sack.\nStore at moderate temperatures in a well-ventilated and dry area", "domain": "chemistry", "round": 3} +{"url": "https://ijettjournal.org/index.php?option=com_content&view=article&id=6553&catid=9", "date": "2023-09-23T01:26:12Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233506429.78/warc/CC-MAIN-20230922234442-20230923024442-00340.warc.gz", "language_score": 0.7180368304252625, "token_count": 1403, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__158362863", "lang": "en", "text": "Nanomaterials For Manufacturing of Functional Prototypes By Additive Manufacturing: A State of The Art Review And Future Research Prospective\n|International Journal of Engineering Trends and Technology (IJETT)||\n|© 2021 by IJETT Journal|\n|Year of Publication : 2021|\n|Authors : Ranvijay Kumar\n|DOI : 10.14445/22315381/IJETT-V69I1P216|\nMLA Style: Ranvijay Kumar. \"Nanomaterials For Manufacturing of Functional Prototypes By Additive Manufacturing: A State of The Art Review And Future Research Prospective\" International Journal of Engineering Trends and Technology 69.1(2021):104-110.\nAPA Style:Ranvijay Kumar. Nanomaterials For Manufacturing of Functional Prototypes By Additive Manufacturing: A State of The Art Review And Future Research Prospective International Journal of Engineering Trends and Technology, 69(1), 104-110.\nAdditive manufacturing has considered as one of the advanced manufacturing processes for the manufacturing of highly sustainable functional prototypes. The previous studies have been reported to manufacture different polymers, metals, alloys, and composite materials, which have been shown a wide range of applicability. Also, the use of conventional materials and processes restrict the broad applicability. Nanomaterials are the class of engineering materials that can provide functionality in the products manufactured by additive manufacturing. The previous studies have reported nanomaterials for the manufacturing of sustainable products with a range of functionalities, e.g., sensing abilities, high mechanical performance, toughness, melting behavior, etc. The present study is a state of the art review for nanomaterials in the additive manufacturing process for future applications.\n T. A. Campbell and O. S. Ivanova.,3D printing of multifunctional nanocomposites.,Nano Today, 8(2)(2013) 119–120. doi: 10.1016/j.nantod.2012.12.002.\n Y. L. Kong, M. K. Gupta, B. N. Johnson, and M. C. McAlpine.,3D printed bionic nanodevices., Nano Today, 11(3)(2016) 330–350. doi: 10.1016/j.nantod.2016.04.007.\n C. W. Peak, K. A. Singh, M. Adlouni, J. Chen, and A. K. Gaharwar.,Printing Therapeutic Proteins in 3D using Nanoengineered Bioink to Control and Direct Cell Migration., Adv. Healthc. Mater.,8(11)(2019). doi: 10.1002/adhm.201801553.\n M. K. Gupta et al., Parametric optimization and process capability analysis for machining nickel-based superalloy., Int. J. Adv. Manuf. Technol., 102(2019) 9–12,3995–4009. doi: 10.1007/s00170-019-03453-3.\n S. Hales et al.,3D printed nanomaterial-based electronic, biomedical, and bioelectronic devices, Nanotechnology, 31(17)(2020), doi: 10.1088/1361-6528/ab5f29.\n J. T. Sehrt, S. Kleszczynski, and C. Notthoff., Nanoparticle improved metal materials for additive manufacturing., Prog. Addit. Manuf., 2(4)(2017) 179–191, doi: 10.1007/s40964-017-0028-9.\n S. Kumar, M. Kumar, and A. Handa Combating hot corrosion of boiler tubes - A study,” Eng. Fail. Anal., 94(2018) 379–395. doi: 10.1016/j.engfailanal.2018.08.004.\n C. Zhu et al., Colloidal materials for 3D printing, Annu. Rev. Chem. Biomol. Eng., 10(2019) 17–42, doi: 10.1146/annurev-chembioeng-060718-030133.\n P. Gairola, S. P. Gairola, V. Kumar, K. Singh, and S. K. Dhawan, “Barium ferrite and graphite integrated with polyaniline as an effective shield against electromagnetic interference, Synth. Met., 221(2016) 326–331 doi: 10.1016/j.synthmet.2016.09.023.\n K. Nau and S. G. Scholz, Safe by design in 3D printing, Smart Innov. Syst. Technol., 155(2019) 341–350 doi: 10.1007/978-981-13-9271-9_28.\n Lalita, A. P. Singh, and R. K. Sharma, Synthesis and characterization of graft copolymers of chitosan with NIPAM and binary monomers for removal of Cr(VI), Cu(II), and Fe(II). metal ions from aqueous solutions, Int. J. Biol. Macromol., 99(2017) 409–426.doi: 10.1016/j.ijbiomac.2017.02.091.\n C. Chen et al., Additive Manufacturing of Piezoelectric Materials, Adv. Funct. Mater., 30 (52)(2020), doi: 10.1002/adfm.202005141.\n N. Makul, Advanced smart concrete - A review of current progress, benefits, and challenges, J. Clean. Prod., 274(2020), doi: 10.1016/j.jclepro.2020.122899.\n S. L. De Armentia, J. C. Del Real, E. Paz, and N. Dunne, Advances in biodegradable 3D printed scaffolds with carbon-based nanomaterials for bone regeneration, Materials (Basel)., 13(22)(2020) 1–49, 2020, doi: 10.3390/ma13225083.\nAdditive Manufacturing, Nanomaterials, Fillers, Fused Filament Fabrication, Sensor Materials, Functional Prototypes, Innovation", "domain": "chemistry", "round": 3} +{"url": "http://mofa.cation97.ru/profile/more-fish-in-the-sea-dating-website46", "date": "2018-11-19T00:36:13Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-47/segments/1542039744803.68/warc/CC-MAIN-20181119002432-20181119024432-00412.warc.gz", "language_score": 0.9487512707710266, "token_count": 327, "dump": "CC-MAIN-2018-47", "global_id": "webtext-fineweb__CC-MAIN-2018-47__0__185195936", "lang": "en", "text": "More fish in the sea dating website\nIn the case of Himalayan sea salt, the number is said to be 84.\nEither way, sea salts are a great source of minerals.\nYou also don’t want a sea salt that lists “sodium chloride” as its main ingredient because this means it’s just as refined as table salt. Unfortunately, some commercial producers of sea salt include health-hazardous additives in their final product, and certain food additives trigger leaky gut.So as much as you hear about making sure you don’t get too much salt in your diet, it’s also absolutely just as important to make sure we get enough. Digestive Health Aid Not getting enough salt in your diet can actually negatively impact your digestive health.If you don’t get enough salt in your diet, it can lead to your body not producing enough hydrochloric acid (HCL) in your stomach.(3) Electrolytes have so many important functions — from regulating your heartbeat to allowing your muscles to contract so you can move.Sea salt in moderation can help in avoiding an electrolyte imbalance, which can cause all kinds of serious negative symptoms, including some that are potentially deadly. Proper Brain, Muscle and Nervous System Function As a provider of sodium, sea salt is not just good for — it’s essential for proper brain, muscle and nervous system function.\nI’m not saying you should start shoveling salt into your mouth, but I want to clarify that there is a major difference between processed table salt and real sea salt.", "domain": "chemistry", "round": 3} +{"url": "https://www.achrinhibitor.com/2022/12/13/6780/", "date": "2023-12-05T15:25:25Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100551.2/warc/CC-MAIN-20231205140836-20231205170836-00823.warc.gz", "language_score": 0.9177451729774475, "token_count": 768, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__94553596", "lang": "en", "text": "Consequent phosphorylation of IKK and IKK. The activated IKK complicated also phosphorylates and inactivates IB, triggering the release and nuclear translocation of your NF-B transcription factor complicated (reviewed in ). NF-B inhibition by ROS and TNF- during extreme oxidative tension In contrast towards the activatory capacity of ROS and TNF- described above, severe types of oxidative pressure and/ or the mixture of oxidative stress and TNF- FGF-10 Proteins manufacturer signaling inhibit the activity of NF-B and market cell death. Whereas minor or moderate levels of oxidative stress cause NF-B activation (Section 220.127.116.11 NF-B activation by ROS), severe oxidative tension features a detrimental impact on NF-B activity . Critical cysteines in NF-B complexes, such as Cys62 on RELA, are susceptible to oxidation and subsequent glutathionylation or nitrosylation, which impairs DNA binding and transcriptional activity [186, 187]. In addition, IKK and IKK include redox-sensitive Cys179, which might be oxidized by H2O2 and decrease IKK kinase activity . These findings suggest that antioxidants developed de novo by means of e.g., the NRF2 pathway might facilitate NF-B activation following a serious prooxidative insult like PDT by ameliorating the oxidative strain, despite the fact that additional investigation is expected to corroborate this claim. TNF- exerts its anti-NF-B effects mainly through mitochondrial ROS production, which may perhaps elevate the extent of preexisting moderate oxidative stress to extreme oxidative pressure and consequent NF-B inhibition by means of the abovementioned processes. By way of example, TNF- remedy was shown to lead to oxidative stress, the cytotoxicity of which may be repressed by the addition of antioxidants . Inhibition of NF-B by TNF–induced oxidative tension stimulates cell death by way of prolonged activation of JNK1, provided that NF-B target gene merchandise such as A20 and development arrested and DNA harm (GADD)45 typically inhibit JNK1 activity. As such, ROS have been thought of to act as a secondary messenger in TNF–induced cell death (reviewed in ). The ROS-dependent activation of your NF-B pathway has many critical biological and clinical implications for PDT. Laser irradiation of tissue is characterized by light intensity attenuation with increasing depth as a result of light scattering and IFN-lambda 4 Proteins Accession absorption , resulting in fluence gradients duringPDT. Inasmuch because the extent of ROS production is proportional to the fluence , the cancer cells within the more distally situated regions of your tumor may exhibit significantly less ROS generation through PDT and therefore are subject to a lower degree of oxidative anxiety than the tumor cells most proximal to the light source. Accordingly, irradiation of bulky tumors could yield a fraction of cancer cells that undergoes cell death without having the activation of ROStriggered survival pathways, whereas one more fraction of cancer cells, positioned mostly at the deep periphery in the target tissue, may possibly suffer from oxidative pressure but survive as a result of ROSmediated activation of e.g., NF-B-mediated survival pathways. The latter fraction of cancer cells is especially important therapeutically inasmuch as these cells might lead to tumor regrowth and metastasis immediately after PDT. three.2.2 Downstream effects of the NF-B pathway The different NF-B transcription factor complexes primarily share precisely the same target genes that happen to be related with cell proliferation, inflammation, angiogenesis, and survival (Fig. 4). NF-B transcription components induce cell proliferation (upregulation of cyc.", "domain": "chemistry", "round": 3} +{"url": "https://pls.llnl.gov/people/staff-bios/msd/wagnon-s", "date": "2018-10-16T17:46:59Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-43/segments/1539583510853.25/warc/CC-MAIN-20181016155643-20181016181143-00280.warc.gz", "language_score": 0.6976691484451294, "token_count": 409, "dump": "CC-MAIN-2018-43", "global_id": "webtext-fineweb__CC-MAIN-2018-43__0__23232819", "lang": "en", "text": "Thermodynamics, heat transfer, fluid mechanics, education, energy efficiency, renewable energy, social/environmental justice, low emission combustion, alternative fuels (e.g., alcohols, biodiesel), \"advanced\" modes of combustor operation (e.g., high pressures, low temperatures, low fuel concentrations), reacting flows, gas-phase chemical kinetics, negative temperature coefficient (NTC) behavior, techniques for compound identification/quantification (e.g., gas chromatography, laser diagnostics), fuel spray/mixing behavior, visualization techniques (e.g., high speed imaging), soot formation and oxidation processes\nHonors and Awards\n- Rowan University Medallion Award – Excellence in Mechanical Engineering, 2009\n- Rowan University Achievement Scholarship, 2005-2009\nSelected (Recent) Publications\nS. W. Wagnon, C. L. Barraza-Botet, M. S. Wooldridge. (2015) \"Effects of Bond Location on the Ignition and Reaction Pathways of trans-Hexene Isomers.\"\nD. Assanis, S. W. Wagnon, M. S. Wooldridge. (2015) \"An Experimental Study of Flame and Autoignition Interactions of iso-Octane and Air Mixtures.\"\nS. W. Wagnon, D. M. A. Karwat, M. S. Wooldridge, C. K. Westbrook. (2014) \"Experimental and Modeling Study of Methyl trans-3-hexenoate Autoignition.\"\nS. W. Wagnon, M. S. Wooldridge. (2014) \"Effects of Buffer Gas Composition on Autoignition.\"\nD. M. A. Karwat, S. W. Wagnon, M. S. Wooldridge, C. K. Westbrook. (2013) \"Low-temperature Chemical Kinetic and Speciation Studies of n-Heptane.\"", "domain": "chemistry", "round": 3} +{"url": "https://publications.drdo.gov.in/ojs/index.php/dsj/article/view/7356", "date": "2021-01-16T03:43:25Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-04/segments/1610703499999.6/warc/CC-MAIN-20210116014637-20210116044637-00004.warc.gz", "language_score": 0.8750816583633423, "token_count": 339, "dump": "CC-MAIN-2021-04", "global_id": "webtext-fineweb__CC-MAIN-2021-04__0__221124872", "lang": "en", "text": "Aniline-Furfural as a Soil Stabiliser\nKeywords: Soil Stabiliser, Aniline-furfural\nAbstractA comparison has been made of aniline-furfural and cement as soil stabilisers with the Gangetic alluvial soil of Delhi. Three compositions of aniline-furfural and two of cement were employed. The 7 day unconfined compressive strength of soil stabilised with resin composition-5% aniline and 2.5% furfural is nearly equal to the strength of soil established with 20% cement. Treatment with aniline-furfural produces high strength of nearly 1 ton per sq. in. when the resin composition is 8% aniline and 4% furfural on soil weight basis. The reduction in strength of the aniline-furfural and cement stabilised soils on being subjected to successive wetting-drying and freezing-thawing cycles is almost the same for both the soils. Stabilisation of soils with aniline-furfural is better suited to cold climates.\nHow to Cite\nWadhawan, S., & Datta, A. (2014). Aniline-Furfural as a Soil Stabiliser. Defence Science Journal, 15(4), 281-286. https://doi.org/10.14429/dsj.15.7356\nCopyright (c) 2016 Defence Science Journal\nWhere otherwise noted, the Articles on this site are licensed under Creative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India", "domain": "chemistry", "round": 3} +{"url": "https://www.spaa.it/en/industry/corroborants/propoli-2/", "date": "2023-03-30T04:45:18Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-14/segments/1679296949097.61/warc/CC-MAIN-20230330035241-20230330065241-00381.warc.gz", "language_score": 0.7178093194961548, "token_count": 285, "dump": "CC-MAIN-2023-14", "global_id": "webtext-fineweb__CC-MAIN-2023-14__0__148645030", "lang": "en", "text": "REGULATIONS: Ministerial Decree No. 6793 of 18/7/2018 – Corroborant\nPlant defence enhancer against fungal and bacterial attacks.\nPROPOLIS derives from resinous substances present in plant tissues that bees collect through salivary secretions and use as a sealant for beehives and to embalm any predatory insects killed.\nDOSES AND METHOD OF USE\n|Fruit trees||500-800 g per 100 litres of water.|\n|Horticulture||500-900 g per 100 litres of water.|\n|Treatment after hail attacks||600-1000 g per 100 litres of water.|\n|Use 400 litres of water per hectare of surface area.|\n|Flavonoid content expressed in galangins||15 mg/ml|\nPHYSICAL AND CHEMICAL PROPERTIES:\n|Density :||1.03 Kg/L|\n|pH (10% sol.)||7.77|", "domain": "chemistry", "round": 3} +{"url": "https://m.scirp.org/papers/29859", "date": "2019-10-14T01:47:59Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-43/segments/1570986648481.7/warc/CC-MAIN-20191014003258-20191014030258-00384.warc.gz", "language_score": 0.7803247570991516, "token_count": 1563, "dump": "CC-MAIN-2019-43", "global_id": "webtext-fineweb__CC-MAIN-2019-43__0__46264501", "lang": "en", "text": "A new unequal\nchannel angular pressing (UCAP) procedure is proposed for ultrafine-grained\nmetals and alloys. The microstructures and mechanical properties of\nMg-5.8Zn-1.2Y-0.7Zr alloys subjected to unequal channel angular pressing (UCAP) are investigated.\nIt is found that the optimum condition in UCAPed alloy is obtained at 523K with a largest elongation\nto failure of 13.1% and ultimate tensile strength of ~400 MPa. Microstructural\nobservations show that the grain size is refined to ~1.0 μm during UCAP. The\nprobable mechanisms for these high mechanical properties are attributed to grain size and destroyed secondary phase\nstrengthening effects and fine precipitates formed during pressing at high\ntemperature by severe shear and plastic deformation.\nCite this paper\nX. Luo, M. Zhang, D. Fang and Y. Chai, \"Microstructure and Mechanical Properties of Medical Magnesium Alloy Fabricated by Unequal Channel Angular Pressing,\" Journal of Biomaterials and Nanobiotechnology, Vol. 4 No. 2, 2013, pp. 132-136. doi: 10.4236/jbnb.2013.42018.\n S. W. Xu, M. Y. Zheng, X. G. Qiao, W. M. Gan, K. Wu, S. Kamado and Y. Kojima, “Microstructure and Tensile Properties of Mg-Zn-Y-Zr Alloy Containing Quasicrystal Phase Processed by Equal Channel Angular Pressing,” Key Engineering Materials, Vol. 350-358, 2007, pp. 595598.\n M. Y. Zheng, S. W. Xu, X. G. Qiao, K. Wu, S. Kamado and Y. Kojima, “Compressive Deformation of Mg-Zn-YZr Alloy Processed by Equal Channel Angular Pressing,” Materials Science and Engineering: A, Vol. 483-484, 2008, pp. 564-567.\n M. Y. Zheng, S. W. Xu, K. Wu, S. Kamado and Y. Kojima, “Superplasticity of Mg-Zn-Y Alloy Containing Quasicrystal Phase Processed by Equal Channel Angular Pressing,” Materials Letters, Vol. 61, 2007, pp. 4406-4408.\n B. Zberg, P. J. Uggowitzer and J. F. Loeffl, “Mg-Zn-Ca Glasses without Clinically Observable Hydrogen Evolution for Biodegradable Implants,” Nature Materials, Vol. 8, No. 11, 2009, pp. 887-891.\n L. Hench and J. M. Polak, “Third-Generation Biomedical Materials,” Science, Vol. 5557, No. 295, 2008, pp. 10141027.\n R. C. Zeng, W. Dietzel, F. Wittel, N. Hort and C. Blawert, “Progress and Challenge for Magnesium Alloys as Biomaterials,” Advanced Engineering Materials, Vol. 10, No. 8, 2008, pp. 3-14.\n Z. Yang, J. P. Li, J. X. Zhang, G. W. Lorimer and J. Robson, “Review on Research and Development of Magnesium Alloys,” Acta Metallurgica Sinica, Vol. 21, No. 5, 2008, pp. 313-328.\n Z. H. Chen, W. J. Xia and H.-G. Yan, “Wrought Magnesium Alloy,” Chemical Industry Press, Beijing, 2005, pp. 3-6. (In Chinese)\n Y. Zhang, X. Q. Zeng , L. F. Liu, L. Chen and H. T. Zhou, “Effects of Yttrium on Microstructure and Mechanical Properties of Hot-Extruded Mg-Zn-Y-Zr Alloys,” Materials Science and Engineering: A, Vol. 373, No. 1-2, 2004, pp. 320-327.\n J. Y. Lee, D. H. Kim and H. K. Lim, “Effects of Zn/Y Ratio on Microstructure and Mechanical Properties of Mg-Zn-Y Alloy,” Materials Letters, Vol. 59, No. 5, 2005, pp. 3801-3805.\n T. Homma, C. L. Mendis, K. Hono and S. Kamado, “Effect of Zr Addition on the Mechanical Properties of As-Extruded Mg-Zn-Ca-Zr Alloys,” Materials Science and Engineering: A, Vol. 527, No. 9, 2010, pp. 23562362.\n D. H. Bae, M. H. Lee, K. T. Kim and W. T. Kim, “Application of Quasicrystalline Particles as a Strengthening Phase in Mg-Zn-Y Alloys,” Journal of Alloys and Compounds, Vol. 445, No. 3, 2002, pp. 445-450.\n D. H. Bae, Y. Kim and I. J. Kim, “Thermally Stable Quasicrystalline Phase in a Super Plastic Mg-Zn-Y-Zr,” Materials Letters, Vol. 60, 2006, pp. 2190-2193.\n Y. Lee, H. K. Lim, D. H. Kim, W. T. Kim and D. H. Jim, “Effect of Icosahedra Phase Particles on the Texture Evolution in Mg-Zn-Y Alloys,” Materials Science and Engineering: A, Vol. 491, No. 1-2, 2008, pp. 349-354.\n T. Peng, Q. D. Wang, M. P. Lu, J. Zheng and J. B. Lin, “An Optimization Approach for Hot Compaction Technology of Mg-10Gd-2Y-0.5Zr Alloy during Solid-State Recycling,” Power Technology, Vol. 194, 2009, pp. 142148.\n L. H. Wen, Z. S. Ji and X. L. Li, “Effect of Extrusion Ratio on Microstructure and Mechanical Properties of Mg-Nd-Zn-Zr Alloys Prepared by a Solid Recycling Process,” Journal of Materials Processing Technology, Vol. 209, 2009, pp. 5319-5324.\n S. W. Xu, M. Y. Zheng, S. Kamado, K. Wu, G. J. Wang and X. Y. Lv, “Dynamic Microstructural Changes during Hot Extrusion and Mechanical Properties of a Mg-5.0 Zn-0.9 Y-0.16Zr (wt%) Alloy,” Materials Science and Engineering: A, Vol. 528, No. 12, 2011, pp. 4055-4064.", "domain": "chemistry", "round": 3} +{"url": "http://vinhodobom.com.br/library/analysis-and-deformulation-of-polymeric-materials-paints-plastics-adhesives", "date": "2019-06-17T07:41:58Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-26/segments/1560627998440.47/warc/CC-MAIN-20190617063049-20190617085049-00143.warc.gz", "language_score": 0.8437364101409912, "token_count": 691, "dump": "CC-MAIN-2019-26", "global_id": "webtext-fineweb__CC-MAIN-2019-26__0__125196429", "lang": "en", "text": "By Jan W. Gooch\nThis useful source offers chemists, formulators, forensic scientists, academics, and scholars with the newest info at the composition of polymeric fabrics. After a dialogue of rules, chapters disguise formulations, fabrics, and research of paint, plastic, and adhesives and describe reformulation the way to try out research effects. a close desk of contents and wide index with listings of appropriate fabrics permits readers quick access to themes. different positive aspects comprise numerous fabrics indexed in response to their trivial, exchange, and clinical names cross-referenced for simple id.\nRead or Download Analysis and Deformulation of Polymeric Materials: Paints, Plastics, Adhesives, and Inks (Topics in Applied Chemistry) PDF\nBest plastics books\nProvides rheological information on a couple of polymers, utilising the grasp curve method of be certain unified curves for every universal kind of polymer. The textual content deals a step by step technique for constructing a speadsheet machine application to acquire actual thermoplastic rheograms at any tempertature with out utilizing refined rheometres.\nContent material: easy options in elastomer synthesis / George Odian -- man made points of crystallizable elastomers / Mario Bruzzone -- Synthesis of elastomers with strain-induced crystallization / Gerd Sylvester and Wolfgang Wieder -- Synthesis and houses of diene elastomers with managed constitution / I.\nThis publication describes the roll-fed thermoforming method, plastic fabrics, layout of thermoformed items, thermoforming machines, trim presses, mildew layout, parts of a whole mould process, mildew structure and computing device base layout, mildew fee estimating, knife-like trim dies, thermoforming offline punch and die trimming\nAdditional resources for Analysis and Deformulation of Polymeric Materials: Paints, Plastics, Adhesives, and Inks (Topics in Applied Chemistry)\nOn interaction with infrared radiation, portions of the incident radiation are absorbed at particular wavelengths. The multiplicity of vibrations occurring simultaneously produces a highly complex absorption spectrum, which is uniquely characteristic of the functional groups comprising the molecule and of the overall configuration of the atoms as well. Suggested review articles on the fundamentals of infrared spectroscopy are Bellamy (1958), Colthup et al. (1964), Gianturco (1965), Herberg (1945), and Nakanishi (1962).\nHowever, none of these efforts can improve on a detailed knowledge of the actual surface topography. • Transmission electron microscopy (TEM). The purpose of this discussion is to describe how transmission electron microscopy has been, or can be, applied to the study of paint surfaces. The transmission microscope (Kane and Larrabee, 1974) is similar to the ordinary optical microscope in that it simultaneously illuminates the whole specimen area and employs Gaussian optics to generate the image.\nMany techniques are used to study surfaces, but most begin with visual examination supplemented by increasing magnification of the light microscope. Straightforward microscopy may be supplemented by either sample-preparation techniques or use of specialized microscope accessories. There are two general methods of observing surfaces, dark-field and brightfield. Each of these, however, can be obtained with transmitted light from a substage condenser and with reflected light from above the preparation.", "domain": "chemistry", "round": 3} +{"url": "https://www.cemrc.org/departments/internal-dosimetry/programs/lie-down-be-counted/we-need-your-help/", "date": "2023-06-04T16:44:06Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-23/segments/1685224650201.19/warc/CC-MAIN-20230604161111-20230604191111-00774.warc.gz", "language_score": 0.9292193651199341, "token_count": 556, "dump": "CC-MAIN-2023-23", "global_id": "webtext-fineweb__CC-MAIN-2023-23__0__81699104", "lang": "en", "text": "Believe it or not, behind the marvels and modern miracles of science are American citizens just like you. Many of the advances discovered by scientific researchers would not have been possible without the help of citizen research volunteers–dedicated individuals who gave their time to further the pursuit of knowledge.\nResearchers at the Carlsbad Environmental Monitoring & Research Center need your assistance. They are studying soil, air, water, native plants and animals in the region around the Waste Isolation Pilot Plant (WIPP).\nThis information will allow scientists to study both naturally occurring and man-made radiation present in the area. Sensitive monitoring equipment provides information about changes in radioactivity near the WIPP site. The baseline data collected prior to the opening of the facility will provide information for studies in the future. As more information is collected over the years, a detailed picture will emerge of environmental radiation in the Carlsbad area.\nTo complete this broad, comprehensive picture, scientists at the Carlsbad Environmental Monitoring & Research Center also have developed a research project to measure the internal radiation in the area’s residents. Called internal dosimetry, this research process uses sensitive counters to measure the tiny amounts of radioactive material typically found inside the human body.\nThe citizens of Carlsbad and the surrounding region have a unique opportunity to be part of a long-term research project that will yield information about their environment and will contribute to the growing body of knowledge about radiation and nuclear energy. Lie Down and Be Counted is the name of the outreach effort to get citizens involved in the Internal Dosimetry Services Project at the Carlsbad Environmental Monitoring & Research Center.\nBy participating, you also will be helping scientists develop better, more sensitive monitoring equipment to protect those who work in the nuclear industries. The project also may lead to improvements in the myriad of medical procedures that use radioactive isotopes and other types of radiation.\nThere are tiny amounts of radioactive materials inside each of our bodies that are natural or that have accumulated through other means. For example, a fraction of all potassium found in our muscles is naturally radioactive. We also come in contact with radioactive elements in nature and some radioactive elements that are man-made. Sources of radioactive material found in nature include minerals, oil, and gases. The man-made elements are primarily the result of above-ground nuclear tests conducted in the past by many countries world-wide or those administered for medical purposes. Scientists estimate that 87 percent of our exposure to radiation comes from natural sources.\nThe Internal Dosimetry Services Project is safe. No radiation is given off by the dosimetry instruments. It is similar to the studies conducted for the safety of workers in nuclear weapons facilities, power plants, and in other industries that employ radioactive materials.", "domain": "chemistry", "round": 3} +{"url": "https://www.cephamls.com/p90rskphospho-thr348-antibody/", "date": "2023-03-29T13:54:50Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-14/segments/1679296948976.45/warc/CC-MAIN-20230329120545-20230329150545-00308.warc.gz", "language_score": 0.7980735898017883, "token_count": 462, "dump": "CC-MAIN-2023-14", "global_id": "webtext-fineweb__CC-MAIN-2023-14__0__6091135", "lang": "en", "text": "KS6A1; MAPKAP-K1a; RPS6KA1; RSK1; S6K-alpha 1\nNCBI Protein: NP_001006666.\nPeptide sequence around phosphorylation site of threonine 348 (S-R-T(p)-P-R) derived from Human p90RSK.\nHuman Mouse Rat\nWB IHC IF Recommended dilution: Predicted MW: 90kd, Western blotting: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200\nBackground / Function\nSerine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB.Silverman E, et al. Mol Cell Biol. 2004 Dec; 24(24): 10573-10583.Andrew D, et al. Biochem J. 2006 February 1; 393(Pt 3): 715\nSupplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.\nShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.\nAntibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.", "domain": "chemistry", "round": 3} +{"url": "https://www.thermofisher.com/antibody/product/CENPP-Antibody-Polyclonal/PA5-31186", "date": "2017-07-20T14:55:12Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-30/segments/1500549423222.65/warc/CC-MAIN-20170720141821-20170720161821-00610.warc.gz", "language_score": 0.7242855429649353, "token_count": 313, "dump": "CC-MAIN-2017-30", "global_id": "webtext-fineweb__CC-MAIN-2017-30__0__162989941", "lang": "en", "text": "|Tested species reactivity||Human, Mouse|\n|Host / Isotype||Rabbit / IgG|\n|Immunogen||Recombinant fragment corresponding to a region within amino acids 60 and 288 of Human CENPP|\n|Purification||Antigen affinity chromatography|\n|Storage buffer||PBS, pH 7, with 20% glycerol|\n|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|\n|Tested Applications||Dilution *|\n|Western Blot (WB)||1:500-1:3000|\n* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.\nPA5-31186 targets CENPP in WB applications and shows reactivity with Human and mouse samples.\nThe PA5-31186 immunogen is recombinant fragment corresponding to a region within amino acids 60 and 288 of Human CENPP.\nCENPP is a subunit of a CENPH (MIM 605607)-CENPI (MIM 300065)-associated centromeric complex that targets CENPA (MIM 117139) to centromeres and is required for proper kinetochore function and mitotic progression (Okada et al., 2006 [PubMed 16622420]).\nFor Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.", "domain": "chemistry", "round": 3} +{"url": "https://www.dpg-verhandlungen.de/year/2017/conference/dresden/part/cpp/session/61/contribution/8", "date": "2021-03-09T08:06:46Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-10/segments/1614178389472.95/warc/CC-MAIN-20210309061538-20210309091538-00448.warc.gz", "language_score": 0.8159187436103821, "token_count": 311, "dump": "CC-MAIN-2021-10", "global_id": "webtext-fineweb__CC-MAIN-2021-10__0__113642577", "lang": "en", "text": "Dresden 2017 – wissenschaftliches Programm\nCPP 61.8: Vortrag\nDonnerstag, 23. März 2017, 16:45–17:00, ZEU 114\nA lattice model to describe lithium ion batteries: insights from Monte Carlo simulations — •Alina Wettstein, Oliver Rubner, and Andreas Heuer — Institut für Physikalische Chemie, Corrensstraße 28-30, 48149 Münster, Deutschland\nNumerous theoretical models have been developed in order to unravel the complex processes which occur in battery electrodes and electrolytes.\nWhile some approaches account for molecular details by employing quantum chemical, molecular dynamics or continuum Monte Carlo calculations, other methods chose a macroscopic ansatz describing the battery cell as a whole system.\nHere we present a lattice Monte Carlo (MC) model which seeks to bridge this gap of time and length scales by incorporating molecular and macroscopic parameters. Our MC model is designed as a modular system, which includes the internal electrochemical processes as well as the particle motion given the relevant interactions and rates within a cell. We study how to compute the major electrical properties of a battery, such as voltage and capacity, with a minimum input of outer parameters and test the influence of molecular properties, for example activation barriers, from MD simulations. With the help of this simplified, but highly flexible approach it is possible to further understand the basic principles of Li-batteries.", "domain": "chemistry", "round": 3} +{"url": "http://dmd.aspetjournals.org/content/11/1/10", "date": "2017-03-29T19:08:16Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-13/segments/1490218191353.5/warc/CC-MAIN-20170322212951-00118-ip-10-233-31-227.ec2.internal.warc.gz", "language_score": 0.9642537832260132, "token_count": 275, "dump": "CC-MAIN-2017-13", "global_id": "webtext-fineweb__CC-MAIN-2017-13__0__56533876", "lang": "en", "text": "Human placental mono-oxygenase activities were markedly increased after additions of micromolar quantities of hematin to reaction vessels. The magnitude of the increases diminished with increasing (induced) levels of hematin-independent activity. The activating effect of hematin could be observed in unbroken cell preparations, in whole homogenates, and in various subcellular fractions. Highest hematin-dependent activity was measured in microsomal fractions of placental homogenates. With benzo(a)pyrene as substrate, response to the stimulatory effect of hematin in human placental preparations was not as profound as that observed in monkey or rabbit placentas but was more marked than the responses observed in placental preparations from rats or mice. Hematin-activated mono-oxygenase activity present in washed microsomal fractions of human placental homogenates could be solubilized with detergents, the most effective of which was Triton N-101. The solubilized activity also could be partially purified by polyethylene glycol fractionation. Attempts to further purify, however, resulted in loss of activity. All results were consistent with the hypothesis that the effect of hematin is mediated via reconstitution of hematin-free apocytochrome(s) P-450.", "domain": "chemistry", "round": 3} +{"url": "https://www.chemverse.in/textile-lubricants.html", "date": "2023-06-10T14:37:38Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-23/segments/1685224657720.82/warc/CC-MAIN-20230610131939-20230610161939-00357.warc.gz", "language_score": 0.7700841426849365, "token_count": 333, "dump": "CC-MAIN-2023-23", "global_id": "webtext-fineweb__CC-MAIN-2023-23__0__266128375", "lang": "en", "text": "Textile Open-EndAntiseize Compound, High Speed/Temp. Grease, Highly stable synthetic lubricant, Bearing Oil, Synthetic Gear Oil, Semi Synthetic Gear Oil, Synthetic Multipurpose Moly Grease for Open-End spinning machine. Texlube Spray for Open-End spinning machines it can be used for traverse guide rod and bush bearing\nHighly Stable Synthetic Lubricant\nProduct Price :Get Latest Price\n|Material||Highly Stable Synthetic Lubricant|\n|Deals in||new only|\n|Product||Highly Stable Synthetic Lubricant|\nIt is highly stable synthetic lubricant\ndesigned for operating under high dynamic loads where speeds are also very high in order of 80,000 -100,000 RPM. It is normally used in place of SYNOL RG -10 grease such as in rotor bearings of Open-End spinning machines operating at higher speeds where oil lubrication is preferable to grease lubrication. It is also a high temperature long life lubricant where operating temperatures go beyond 220 C.\nArea of Application:\n- It is used for the clutch of the feed speed variable gear box, reverse motion feed box bearings and gears of Open-End spinning machines.\n- Long life lubricant for high speed applicationsExcellent lubricity and low friction under high dynamic loads\n1-litre plastic bottle and 5-litre Carboy", "domain": "chemistry", "round": 3} +{"url": "http://recob-tlse.org/%EF%BB%BFscale-pub-10-m/", "date": "2022-10-07T14:54:43Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-40/segments/1664030338213.55/warc/CC-MAIN-20221007143842-20221007173842-00679.warc.gz", "language_score": 0.8736919164657593, "token_count": 1267, "dump": "CC-MAIN-2022-40", "global_id": "webtext-fineweb__CC-MAIN-2022-40__0__86036135", "lang": "en", "text": "Scale pub 10 M\nScale pub 10 M. metabolic activity in resting NSM2-deficient T cells does not support sustained response upon activation. While elevated under steady-state conditions in NSM2-deficient CD4+ T cells, the mTORC1 pathway regulating mitochondria size, oxidative phosphorylation, and ATP production is definitely impaired after 24 h of activation. Taken collectively, the absence of NSM2 promotes a hyperactive metabolic state in unstimulated CD4+ T cells yet fails to support sustained T cell reactions upon antigenic activation. gene which generates ceramides in the neutral pH optimum. It was 1st isolated from rat mind as an enzyme mainly bound to the membranes (Liu et al., 1998). NSM2 activity is definitely important for bone development and mineralization (Aubin et al., 2005; Stoffel et al., 2005), takes part in cellular stress reactions or cytokine-mediated swelling (IL1-, TNF-, IFN-), and also happens after engagement of TNFR1, CD95, CD40, and TCR (Tonnetti et al., 1999; Airola and Hannun, 2013; Mueller et al., 2014; Shamseddine et al., 2015). NSM2 is bound to the cytosolic plasma membrane leaflet via N-terminal hydrophobic segments and produces ceramides there (Hinkovska-Galcheva et al., 1998; Tani and Hannun, 2007). Local reduction of sphingomyelin by sphingomyelinase activity results in increase of ceramides and generation of cholesterol which is definitely free from stable connection with sphingomyelin, probably modifying membrane microdomain properties and overall performance in signal initiation. We while others found that NSM2-deficient cells have decreased plasma membrane ceramide levels and deregulated cholesterol homeostasis resulting in improved intracellular and plasma membrane Y-29794 oxalate build up of cholesterol (Qin et al., 2012; Bortlein et al., 2019). When compared to those measured in mind or liver, expression levels of NSM2 in T-cells are rather low (Hofmann et al., 2000). However, NSM2 activity proved to have a considerable impact on T-cell cytoskeleton dynamics, morphological polarization, and migration toward chemotactic signals, and, most importantly, for the optimal overall performance of TCR signaling (Gassert et al., 2009; Collenburg et al., PTGS2 2017; B?rtlein et al., 2018). Our more recent studies recognized the TCR/NSM2/PKC pathway as important for TCR transmission amplification and sustainment especially at low doses of activation (B?rtlein et al., 2018). At a cellular level, NSM2-driven ceramide production essentially controlled PKC – dependent microtubule-organizing center (MTOC) dynamics as required for recycling and sustained supply of TCR signaling parts to the plasma membrane in Y-29794 oxalate the immune synapse. Most importantly, NSM2 activity was also required for posttranslational modifications of tubulin such as acetylation and detyrosination which regulate its stability and microtubule polymerization. While these studies clearly support the importance of NSM2 in stimulated T cell response, they did not address a potential effect of the enzyme on sphingolipid homeostasis in T cells and, consequently, on T cell rate of metabolism. T-cells undergo adaptive metabolic changes upon exit from quiescence, activation, and differentiation. Metabolic adaptation is definitely decisive for the practical outcome of immune reactions (Jung et al., 2019). In na?ve T-cells, lymphatic S1P promotes mitochondria function and oxidative phosphorylation OXPHOS is the main source for ATP production while glycolytic activity is definitely marginal (Pearce et al., 2013; Mendoza et al., 2017). Upon T-cell activation glucose, amino acid rate of metabolism and OXPHOS are upregulated as is definitely glycolysis which is referred to as glycolytic switch (Geltink et al., 2018). Along with improving glycolysis, triggered T cells actively restrain the Y-29794 oxalate oxidation of amino acids and lipids to produce ATP, while these substrates then rather serve as building blocks to support proliferation and cellular growth (Bauer et al., 2004). Signaling of the mechanistic target of rapamycin complex-1 (mTORC1) is essential for naive T-cell exit from quiescence, mitochondrial biogenesis, and activation of one-carbon rate of metabolism (Yang et al., 2013; Ron-Harel et al., 2016). Maintenance of mitochondria membrane integrity and function of electron transport chain (ETC) during activation is vital for T-cell effector function, and this depends on both proteins and lipids (Schenkel and Bakovic, 2014; Tarasenko et al., 2017), for example, mitochondria membrane protein voltage-dependent anion-selective channel 1 (VDAC1) functions in the metabolic cross-talk between mitochondria and cellular energy production (Shoshan-Barmatz et al., 2017). The specifically mitochondrial membrane phospholipid cardiolipin CL is an essential component of mitochondria membrane and regulates mitochondria membrane potential and structural architecture. Deregulation of CL and cholesterol levels in mitochondria have been implicated in several human being diseases, such as Barth syndrome and NiemannCPick C1 disease (Barth et al., 1983; Porter et al., 2010). The importance of sphingolipid rate of metabolism in sustaining mitochondria features has been recorded for cells of non-hematopoietic source. Mitochondrial neutral sphingomyelinase activity and ceramides contribute to the damage of mitochondrial integrity and impaired OXPHOS in the heart reperfusion damage model (Ramirez-Camacho et al., 2016). Neutral sphingomyelinase in skeletal muscle mass myotubes inhibits ATP production and mitochondrial gene manifestation and enhances fatty.", "domain": "chemistry", "round": 3} +{"url": "https://www.ars.usda.gov/research/publications/publication/?seqNo115=124393", "date": "2023-09-25T01:02:09Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233506669.96/warc/CC-MAIN-20230924223409-20230925013409-00423.warc.gz", "language_score": 0.9187948703765869, "token_count": 334, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__109189165", "lang": "en", "text": "Submitted to: Society for Leukocyte Biology Meetings Proceedings\nPublication Type: Abstract Only\nPublication Acceptance Date: 11/9/2001\nPublication Date: N/A\nTechnical Abstract: Protein tyrosine phosphorylation is a central mechanism that mediates signal transduction events involved in many cellular processes. Protein tyrosine kinase (PTK) is the mediating enzyme in this signal transduction pathway. Previous studies from our laboratory have demonstrated a dramatic inhibition of oxidative burst and degranulation in chicken heterophils following treatment with the PTK inhibitor, genistein. These results are indicative of the critical nature of protein tyrosine phosphoryltion as a signaling event during functional activity. The purpose of these experiments was to detect and quantitate PTK in heterophils isolated from day of hatch chicks with a commercial kit. Our data demonstrate a significant increase (P<0.05) in the quantity of PTK present in control heterophils vs LPS stimulated heterophils isolated from day-old chicks. Quantitatively, PTK levels were significantly decreased (P<0.05) between genistein treated heterophils (PTK inhibitor) and LPS stimulated heterophils. Our data demonstrate PTK is present in the heterophils of day-old chicks. The presence of PTK and our ability to detect increased and decreased levels in day-old chicken heterophils is indicative of protein tyrosine phosphorylation which mediates signal transduction events at the cellular level.", "domain": "chemistry", "round": 3} +{"url": "http://sprentland.com/the-pathway-of-ceramide-synthesis-continues-to-be-implicated-in-gw788388/", "date": "2022-08-13T09:31:49Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571911.5/warc/CC-MAIN-20220813081639-20220813111639-00120.warc.gz", "language_score": 0.8884862661361694, "token_count": 1051, "dump": "CC-MAIN-2022-33", "global_id": "webtext-fineweb__CC-MAIN-2022-33__0__77172032", "lang": "en", "text": "The pathway of ceramide synthesis continues to be implicated in GW788388\nMay 31, 2017\nThe pathway of ceramide synthesis continues to be implicated in GW788388 the pathogenesis of excessive lung apoptosis and murine emphysema. Intermediate-chain length (C8:0) extracellular ceramides used as a surrogate of paracellular ceramides triggered caspase-3 activation in primary mouse lung endothelial cells similar to TNF-α-generated endogenous ceramides. Inhibitory siRNA against serine palmitoyl transferase subunit 1 but not acid sphingomyelinase inhibited both C8:0 ceramide- and TNF-α (plus cycloheximide)-induced apoptosis consistent with the requirement for activation of the pathway of sphingolipid synthesis. Tandem mass spectrometry analysis detected increases in both relative and absolute levels of C16:0 ceramide in response to C8:0 and TNF-α treatments. These results implicate the pathway of ceramide synthesis in the apoptotic effects of both paracellular ceramides and TNF-α-stimulated intracellular ceramides in primary lung endothelial cells. The serine palmitoyl synthase-regulated ceramides synthesis may contribute to the amplification of pulmonary vascular injury induced by excessive ceramides. pathway involving upstream activation of the serine palmitoyl transferase (SPT) and the sphingomyelinase pathway through acid (ASMase) or neutral sphingomyelinase activation. GW788388 Alternatively intracellular ceramide levels may also increase by blocking its metabolic clearance. It has been suggested that individual ceramide varieties could play specific biological jobs (6). Moreover the precise ceramide varieties induced by intermediate-chain ceramides or by TNF-α stay undefined. Using pharmacological inhibitors inside a style of murine emphysema we’ve demonstrated that ceramide up-regulation via the pathway was crucial for lung cell apoptosis which ceramide activation happened upstream of caspase-3 activation (1). Oddly enough the ASMase (particularly its soluble isoform) however not the natural sphingomyelinase was also triggered in this style of emphysema and could possess accounted for the improved creation of endogenous paracellular ceramides in response to exogenous ceramide (1). These total results have raised many questions. First will the uptake of bioactive (extracellular) ceramide GW788388 result in fresh synthesis of endogenous ceramides to activate caspases in major lung endothelial cells and if therefore where pathway? Second will there be a FAZF common pathway of ceramide synthesis necessary for pro-apoptotic signaling in these cells? To handle these queries we examined endogenous ceramide varieties produced in response GW788388 to extracellular ceramide or TNF-α another result in of endothelial apoptosis. Previously researchers utilized exogenous ceramide to imitate the action from the intracellular signaling ceramide. Furthermore because of limited solubility mainly very-short string (C2-C6) ceramides have already been researched in cell tradition systems. The idea of our function was that bioactive paracellular swimming pools of ceramides may initiate specific intracellular signaling occasions in comparison to the intracellular-generated ceramides. We contacted these experimental queries using little inhibitory RNA strategies in conjunction with mass spectrometric measurements of ceramide varieties and utilizing longer-chain C8:0 ceramides which might be more highly relevant to mobile responses to normally happening ceramides. Our outcomes a few of that have been previously shown in abstract type (7) indicate how the serine palmitoyl transferase (SPT)-triggered pathway of sphingolipid synthesis is essential for pro-apoptotic intracellular ceramide era in major mouse lung endothelial cells in response to both extracellular ceramide and TNF-α. We then compared the kinetics and design of intracellular ceramide varieties generated by both stimuli using mass spectrometry. Strategies and Components Chemical substances and Reagents N-Octanoyl-D-ceramide synthesis. The following major antibodies were utilized: energetic caspase-3/7 (Cell Signaling Technology Beverly MA and Abcam Cambridge MA) caspase-8 (IC12 Cell Signaling) ASMase (Santa Cruz Biotechnologies Santa Cruz CA and from E.S.) SPT (Abgent NORTH PARK CA) actin (Calbiochem La Jolla CA) vinculin (Calbiochem) and GAPDH (Abcam). Human being recombinant TNF-α and all the reagents had GW788388 been from Sigma-Aldrich (St. Louis MO) unless in any other case specified. Cell Tradition Experiments Major mouse lung microvascular endothelial cells had been obtained as referred to (8 9 and tests had been performed up to passing 18. Cells had been maintained in full culture.", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/apobec3cpbi-antibody-ab72652.html", "date": "2019-11-14T08:42:33Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-47/segments/1573496668334.27/warc/CC-MAIN-20191114081021-20191114105021-00160.warc.gz", "language_score": 0.773874044418335, "token_count": 560, "dump": "CC-MAIN-2019-47", "global_id": "webtext-fineweb__CC-MAIN-2019-47__0__151537440", "lang": "en", "text": "Product nameAnti-APOBEC3C/PBI antibody\nSee all APOBEC3C/PBI primary antibodies\nDescriptionMouse polyclonal to APOBEC3C/PBI\nTested applicationsSuitable for: WBmore details\nSpecies reactivityReacts with: Human\nFull length protein corresponding to Human APOBEC3C/PBI.\nDatabase link: NP_055323.2\n- APOBEC3C/PBI transfected 293T cell lysate\nThis product was previously labelled as APOBEC3C\nStorage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.\nStorage bufferpH: 7.20\nConstituent: 2.68% PBS\nConcentration information loading...\nPurityProtein A purified\nOur Abpromise guarantee covers the use of ab72652 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\n|WB||1/500 - 1/1000. Predicted molecular weight: 23 kDa.|\nFunctionHost cellular restriction factor that may have antiviral activities against exogenous and endogenous viruses, as well as retrotransposons. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.\nTissue specificityExpressed in spleen, testes, peripherical blood lymphocytes, heart, thymus, prostate and ovary.\nSequence similaritiesBelongs to the cytidine and deoxycytidylate deaminase family.\n- Information by UniProt\n- A3C antibody\n- ABC3C_HUMAN antibody\n- APOBEC1 like antibody\nAll lanes : Anti-APOBEC3C/PBI antibody (ab72652) at 1/500 dilution\nLane 1 : APOBEC3C/PBI transfected 293T cell lysate\nLane 2 : Non transfected 293T cell lysate\nLysates/proteins at 25 µg per lane.\nLane 1 : Goat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilution\nLane 2 : Goat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilution\nPredicted band size: 23 kDa\nObserved band size: 20 kDa why is the actual band size different from the predicted?\nab72652 has not yet been referenced specifically in any publications.", "domain": "chemistry", "round": 3} +{"url": "https://socratic.org/questions/even-if-i-keep-on-increasing-the-frequency-why-does-the-no-of-photo-electrons-em#632716", "date": "2024-04-14T16:59:02Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712296816893.19/warc/CC-MAIN-20240414161724-20240414191724-00207.warc.gz", "language_score": 0.8978066444396973, "token_count": 329, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__11972888", "lang": "en", "text": "Even if i keep on increasing the frequency,why does the no of photo-electrons emitted from a metal surface reach a maximum and remain constant at that value?\nThe number of incident photons (and hence electron emitted if any) per unit time is dependent on the intensity of the incoming radiation but not its wavelength or frequency.\nAn incident photon will ionize a single electron upon collision if the energy\n- Emission of an electron if\n#h * color(navy)(f) = E > phi#\n- No emission if\n#h * color(navy)(f) = E < phi#\nIt is worth noting that despite the absorption of the incident photon, none of its energy would remain on the metallic surface or go to a second electron. Part of the photon energy is converted to electrical potential energy as the photoelectric electron leaves the potential well; the rest is converted to the kinetic energy of the electron. That is:\nMeaning that it is not possible for the metal surface to retain any of the photon's energy in a way that would allow the emission of another electron in the absence of incident photons, or for the electron emitted to release another photon that will ionize the second electron following the absorption of the initial photon. Neither is it possible for the photon to hit two electrons simultaneously since by the Pauli Exclusion principle the two electrons cannot occupy the identical quantum state.\nThus the frequency- or equivalently the energy- of the photon only decides whether there is an emission along with the energy of the electron emitted in cases of emission.", "domain": "chemistry", "round": 3} +{"url": "https://petroleumservicecompany.com/chevron-techron-fuel-system-cleaner-6-20-ounce-bottles/", "date": "2021-05-15T16:42:46Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-21/segments/1620243990551.51/warc/CC-MAIN-20210515161657-20210515191657-00548.warc.gz", "language_score": 0.8617832660675049, "token_count": 306, "dump": "CC-MAIN-2021-21", "global_id": "webtext-fineweb__CC-MAIN-2021-21__0__150914679", "lang": "en", "text": "CHEVRON TECHRON FUEL SYSTEM CLEANER in 6/20 Ounce Bottles\nChevron Techron Fuel System Cleaner is a clean up solution for gas-powered auto engines. When used every 3,000 miles the results are unsurpassed in cleaning the entire fuel system (fuel injectors, intake valves and combustion chambers) in one tankful. Its use can maximize fuel economy and restore lost power, performance and acceleration by breaking up and clearing away stubborn carbon deposits.\nChevron Techron Fuel System Cleaner is suitable for use in:\nGasoline two-stroke air-cooled engines (motorcycle or chainsaw)\nGasoline two-stroke water-cooled engines (motorcycle or marine)\nGasoline four-stroke lawnmower, motorcycle and marine engines Will not harm catalytic converters and oxygen sensors. Not recommended for diesel engines.\nClean deposits from fuel injectors, carburetors, intake valves, and combustion chambers\nCleans, restores, and protects the entire fuel system, including sulfur-contaminated fuel gauge sensors\nOne tankful of fuel treated with Techron Concentrate Plus, Complete Fuel System Cleaner, can help: Maximize fuel economy, Restore lost power and performance, Restore and protect operation of the fuel gauge sensor, Minimize harmful exhaust emissions, Relieve cold start problems, Minimize deposit-related knock and ping, Restore lost acceleration, Remove deposits from two-stroke engine", "domain": "chemistry", "round": 3} +{"url": "https://iomosaic.com/about/our-team/presentation-detail/docs/default-source/Publications/a-review-of-the-aqaba-bay-chlorine-incident", "date": "2024-02-26T00:30:26Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707947474649.44/warc/CC-MAIN-20240225234904-20240226024904-00042.warc.gz", "language_score": 0.9580404758453369, "token_count": 297, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__91745382", "lang": "en", "text": "On 27 June 2022, a release of chlorine caused the deaths of thirteen people at the port facilities in Aqaba, Jordan. The release occurred when a large 25 tonne vessel of liquefied chlorine gas was being loaded by crane to a ship in Aqaba port.\nChlorine is widely used for chemical processes such as carbon tetrachloride, glycols, and other organic compounds for the manufacture of plastics, dyes, and synthetic rubber. Additionally, chlorine is used to sterilize water and wastes, and as a bleaching agent for paper or textiles.\nDuring the loading operation, a cable snapped causing the vessel to drop and catastrophically fail, immediately discharging the full 25 tonne inventory which rapidly vaporized. In addition to the 13 fatalities due to toxic inhalation of chlorine, over 250 people were also injured as the cloud spread. Remarkably, the incident was captured on video, and widely shared on social media.\nThis presentation discusses the hazards of chlorine, the events surrounding the incident, as well as the root causes and contributing factors. Consequence modeling is used to replicate the incident; and official conclusions and recommendations are reviewed. The importance of human factors risk management, and the severe consequences of complacence are highlighted, with additional recommendations provided by the authors.\nTo download our resources, you must become a registered site user. After you register, you will receive an email with a login username and password.", "domain": "chemistry", "round": 3} +{"url": "https://speed.bharatpetroleum.in/en-us/SitePages/Speed.aspx", "date": "2020-06-04T23:45:26Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-24/segments/1590348492295.88/warc/CC-MAIN-20200604223445-20200605013445-00024.warc.gz", "language_score": 0.921076774597168, "token_count": 429, "dump": "CC-MAIN-2020-24", "global_id": "webtext-fineweb__CC-MAIN-2020-24__0__37577580", "lang": "en", "text": "Speed is enriched with special Multi-Functional Additives (MFA) that keep your vehicle's engine clean thereby maximizing its power. Speed also lowers vehicular emissions, ensuring reliable engine performance and a smoother drive.\n“Speed\" is a premium gasoline blended with a world-class Multi-Functional Additive (MFA) which effectively controls the harmful deposits from all fuel metering systems and components viz. Fuel Injectors/Carburettor, Intake valves/ports and combustion chamber, resulting in enhanced overall engine performance i.e. easier starting/smoother idling, improved power and acceleration. As a result, “Speed\" helps in achieving fuel economy benefits of up to 2%.\nIn any new vehicle the fuel injectors, intake valves and combustion chamber are free from deposits. Over a period of time deposits begin to accumulate on these engine parts, and may affect fuel economy, power output and driving comfort. The superior additive chemistry of “Speed\" cleans-up these deposits and keeps those vital engine parts clean over the long term. This helps in sustaining and restoring original engine performance leading to increased power and better acceleration and thus improved driveability.\nThe deposits formed on Intake Valves & Ports may soak up fuel components like a sponge; leading to non-optimal fuel-air mixture which can cause poor combustion, thus impacting emissions. Deposits formed in the combustion chamber can also increase emissions and lead to, Octane Requirement Increase (ORI) if uncontrolled. The MFA technology used in “Speed\" can clean-up the harmful deposits from Intake Valves & Ports, and fuel injectors and control combustion chamber deposits. The MFA not only cleans the deposits from the above mentioned parts but also prevent the formation of new deposits; making vehicle engines work as good as new through much of their lifetime. Fuel injector deposit control can improve fuel spray pattern and enable optimal fuel-air mixture which enhances combustion thus reducing emissions.\n“Speed\" provides all round protection to fuel system components from rust & corrosion. On the whole, a cleaner engine means reduced maintenance.", "domain": "chemistry", "round": 3} +{"url": "https://www.linknovate.com/affiliation/toxicam-nucleus-of-evaluation-of-environmental-impact-on-human-health-1641018/all/", "date": "2017-10-22T19:33:34Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-43/segments/1508187825436.78/warc/CC-MAIN-20171022184824-20171022204824-00045.warc.gz", "language_score": 0.912470281124115, "token_count": 484, "dump": "CC-MAIN-2017-43", "global_id": "webtext-fineweb__CC-MAIN-2017-43__0__185629303", "lang": "en", "text": "TOXICAM Nucleus of Evaluation of Environmental Impact on Human Health\nSaid R.A.,State University of Santa Cruz |\nGrassi T.F.,TOXICAM Nucleus of Evaluation of Environmental Impact on Human Health |\nScolastici C.,TOXICAM Nucleus of Evaluation of Environmental Impact on Human Health |\nAlves de Lima R.O.,TOXICAM Nucleus of Evaluation of Environmental Impact on Human Health |\nAnd 3 more authors.\nExperimental and Toxicologic Pathology | Year: 2010\nPropolis (bee glue) is a complex mixture of natural substances that exhibits a broad spectrum of biological activities. As the possibility exists that it may exert a chemopreventive role against cancer development, the present study aimed to evaluate the chemopreventive influence of a Brazilian aqueous propolis extract (APE) in a rat two-stage (initiation-promotion) medium-term bioassay for chemical liver carcinogenesis. Male Wistar rats were sequentially initiated with diethylnitrosamine (DEN, 200. mg/kg. b.w.) and, 2 weeks later, exposed to a diet containing hexachlorobenzene (HCB, 100. ppm) and to APE 0.1% through drinking water for 6 weeks. Appropriate control groups were also established. The animals were sacrificed at the weeks 8th and 30th when liver samples were processed to evaluate the development of altered hepatocyte foci (AHF) identified under hematoxylin and eosin (H&E) staining and by the immunohistochemical expression of the enzyme glutathione S-transferase placental form (GST-P). The results indicate that APE 0.1% did not protect against the development of any of the differentially identified putative preneoplastic foci in DEN-initiated animals, exposed or not to the promoting agent HCB. Also, APE 0.1% by itself did not significantly induce any AHF, what is in line with its already known absence of genotoxic potential. Our results indicate that an aqueous extract of Brazilian propolis did not exert chemoprevention on the hepatocarcinogenesis process chemically induced in the rat. © 2009 Elsevier GmbH.", "domain": "chemistry", "round": 3} +{"url": "https://www.assignmentworkers.com/household-hazardous-waste-in-different-countries-essay/", "date": "2023-06-08T04:51:01Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-23/segments/1685224654097.42/warc/CC-MAIN-20230608035801-20230608065801-00409.warc.gz", "language_score": 0.9206515550613403, "token_count": 480, "dump": "CC-MAIN-2023-23", "global_id": "webtext-fineweb__CC-MAIN-2023-23__0__163387270", "lang": "en", "text": "In general, the amount of generated household hazardous waste in European countries, Canada, Greenland, India, Japan, Pakistan. And the United States increased from 0,4 to 7,9 kilograms per person annually (Lim-Wavde & Kauffman, n.d.). The major part of the global household hazardous waste stream is electronic waste, as mobile phones became highly affordable.\nIn the UAE, the management of hazardous waste is constantly developing, while the community members level of awareness of waste management is considerably low. According to the research conducted by Al Sharawy, et al. (2019), almost 60% of participants reported that they do not take any precautions when disposing of hazardous products and they just throw them in the general waste (p. 746). Almost 70% of , along with hazardous waste, is disposed of in landfills (Al Sharawy, et al., 2019).\nIn the Czech Republic, household hazardous waste comprises 2,047% of the municipal solid wastes general stream (Adamcov, et al., 2016). Hazardous substances traditionally include paints, , vehicle maintenance products, batteries, and pharmaceuticals. As 70% of solid waste is disposed of in landfills, these substances are poorly controlled they are not collected separately and recycled (Adamcov, et al., 2016).\nIn China, the rate of household hazardous waste generation has recently been more than 6g per person daily that has accounted for 2,23% of the total household solid waste stream (Gu, et al., 2014). The main categories of hazardous waste include home cleaning products, medicines, and personal care products (Gu, et al., 2014). Single-use products, containers, and packaging accounted for 80% of the total household hazardous waste generation (Gu, et al., 2014).\nIn Mexico, the rates of household hazardous waste generation considerably vary across the country. In the central region, household hazardous waste totals 1,03% of general municipal solid waste, and it is predominantly represented by cleaning products, self-care products, and insecticides (Delgado, et al., 2007). At the same time, in the countrys northern region, the household hazardous wastes generation comprises 3,7% of the general municipal solid waste stream with the largest categories of , cleaning products, electronic equipment, and batteries (Delgado, et al., 2007).", "domain": "chemistry", "round": 3} +{"url": "https://www.siftdesk.org/index-article/A-new-ELISA-method-for-the-measurement-of-total-%CE%B12-plasmin-inhibitor-level-in-human-body-fluids-/720412/39", "date": "2023-06-06T15:26:14Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-23/segments/1685224652959.43/warc/CC-MAIN-20230606150510-20230606180510-00489.warc.gz", "language_score": 0.9144652485847473, "token_count": 423, "dump": "CC-MAIN-2023-23", "global_id": "webtext-fineweb__CC-MAIN-2023-23__0__147901269", "lang": "en", "text": "The ever-increasing research efforts to develop new antithrombotic therapies have led to the reassessment of the role of alpha-2-plasmin inhibitor (α2-PI) in pathological conditions. In particular, experimental stroke studies have suggested correlation between increased free α2-PI level and mortality. However there are only a small number of well-characterized and specific assays available for the measurements of free α2-PI. In plasma α2-PI undergoes both N- and/or C-terminal cleavages resulting four isoforms with modified susceptibility to FXIII catalyzed cross-linking to fibrin and/or loss of plasmin(ogen) binding. Present paper describes a new sandwich ELISA method for the determination of free total α2-PI in plasma and other body fluids. A newly generated biotinylated monoclonal antibody recognizes and captures all the four N- and/or C-terminally modified isoforms of α2-PI while HRPO-labeled polyclonal anti-α2-PI antibody detects the captured antigen. Performing the 2-step assay in streptavidin-coated microplate can be completed within three hours. The assay is well reproducible, total (within laboratory) imprecision in the normal, pathological and very low ranges were 7.4%, 9.1% and < 19%, respectively. When examining the plasma samples of 197 healthy volunteers, 100 acute ischemic stroke patients and 102 patients with venous thrombosis, strong correlation was observed between total α2-PI antigen levels and α2-PI activity for each group. Using the assay a reference interval of 45-86 mg/L was established for total α2-PI mass concentration in the plasma. α2-PI levels were also measured in cerebrospinal fluid samples of 47 individuals the median value and range was 132 (36-379) μg/L. In conclusion, our ELISA enables accurate and fast measurement of total free α2-PI in human body fluids.", "domain": "chemistry", "round": 3} +{"url": "https://tuolianmetal.com/hastelloy-c276-pipe/", "date": "2024-02-28T23:19:07Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707947474746.1/warc/CC-MAIN-20240228211701-20240229001701-00499.warc.gz", "language_score": 0.8927924036979675, "token_count": 305, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__113643090", "lang": "en", "text": "Hastelloy C276 Pipe\nHastelloy C276 pipe is a type of corrosion-resistant pipe made from the nickel-molybdenum-chromium alloy. A hostile environment with chemicals, acids, and high temperatures makes this alloy very corrosion-resistant. First-class quality Hastelloy C276 pipes are produced by carrying out the process of solid solution, cold drawn, hot drawn, bright annealed, and hot extruding.\nHastelloy C276 Pipe Manufacturer\nTuoLian Hastelloy C276 pipes are employed in a number of sectors, including chemical processing, paper production, waste management, and power generation, where corrosion resistance is essential for both safe and effective operation. These pipes are usually welded or seamless and are offered in a range of thicknesses and sizes to accommodate different purposes. Our C276 pipes are fabricated in a variety of different shapes and compositions, including round, square, rectangular, straight, U-shape, coiled, hollow, hydraulic, etc.\nWe, TuoLian confirms the guarantee that all Hastelloy C276 pipes meet all the standards and test certificates required for high-quality pipes. These include the hardness test, flattening test, flaring test, mechanical test, micro and macro test, pitting resistance test, positive material identification testing, chemical analysis, raw material test, surface, roughness measurement, and more.\nContact TuoLian Now for your Hastelloy C276 Pipe!", "domain": "chemistry", "round": 3} +{"url": "https://www.e3s-conferences.org/articles/e3sconf/abs/2020/06/e3sconf_sca2019_03001/e3sconf_sca2019_03001.html", "date": "2023-09-27T04:07:09Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233510259.52/warc/CC-MAIN-20230927035329-20230927065329-00610.warc.gz", "language_score": 0.8775666356086731, "token_count": 644, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__54186720", "lang": "en", "text": "E3S Web Conf.\nVolume 146, 2020The 2019 International Symposium of the Society of Core Analysts (SCA 2019)\n|Number of page(s)||12|\n|Section||Improved SCAL Techniques and Interpretation|\n|Published online||05 February 2020|\nPermeability alteration by salt precipitation: numerical and experimental investigation using X-Ray Radiography\n1 IFP Energies Nouvelles, Rueil-Malmaison France\n2 Equinor, Trondheim, Norway\nThe injection of a gas phase through a water saturated porous medium can reduce the water saturation not only by displacement mechanisms but also by evaporation mechanisms. In the presence of brine, this process can induce salt crystallization and precipitation within the porous medium with a risk of permeability alteration. In the field of gas production and storage, the occurrence of such a phenomenon can have detrimental consequence on the well productivity or injectivity. In this work, we investigated experimentally and numerically the effect of dry gas injection on salt precipitation and permeability impairment. State of the art equipment designed for high throughput coreflood experimentation was used to capture the dynamic of salt migration using X-Ray radiography. A set of experiments have been conducted on a sample of Bentheimer sandstone (10mm in diameter and 20 mm in length) as well as a two layers composite sample with a significant permeability contrast. Experiments were conducted using Nitrogen and KBr brine with different boundary conditions (i.e. with and without capillary contact). Results showed that salt precipitation results from the interplay of different parameters, namely pressure gradient, brine salinity, capillary forces and vapor partial pressure. Experimental observations indicate that in the case of dry gas injection, salt systematically precipitates but permeability alteration is observed only if a capillary contact is maintained with the brine. We built a 2D flow model integrating two-phase Darcy flow, capillary forces, salt effect on vapor partial pressure, dissolved salt transport, as well as the different PVT equilibria needed to describe properly the systems. Once calibrated, the model showed good predictability of lab scale experiment and thus can be used for parametrical study and upscaled to the well bore scale.\n© The Authors, published by EDP Sciences, 2020\nThis is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.\nCurrent usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.\nData correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.\nInitial download of the metrics may take a while.", "domain": "chemistry", "round": 3} +{"url": "https://mechtechguru.com/2020/05/modern-manufacturing-process-mechanical-processes-electrochemical-processes/", "date": "2024-04-22T06:08:00Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712296818081.81/warc/CC-MAIN-20240422051258-20240422081258-00559.warc.gz", "language_score": 0.9258493781089783, "token_count": 540, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__20249292", "lang": "en", "text": "Modern manufacturing process\nModern manufacturing techniques have often been classified according to the principal type of energy utilized to remove or add material— mechanical, electrical, thermal, and chemical.\nUltrasonic machining and abrasive jet machining are the two primary (nontraditional) mechanical processes. Material is removed through erosion, where hard particles (in a liquid slurry) are forced into contact with the workpiece at very high speeds.\nElectrochemical machining is the primary representative of this group. It uses electrolysis to remove material from a conductive workpiece submerged in an electrolyte bath; particles depart from the anodic workpiece surface toward a cathodic tool and get swept away by the high-speed flowing electrolyte liquid.\nElectrical discharge machining, electron beam machining, and laser beam machining are the three primary thermal energy–based processes. Metal removal in electrical discharge machining is achieved through high-frequency sparks hitting the surface of a workpiece submerged in a dielectric liquid bath. In electron beam machining, a high-speed stream of electrons impinge on a very small focused spot on the surface of the workpiece and, as in electrical discharge machining, vaporize the material (this is preferably carried out in a vacuum chamber). Laser beam machining is utilized for the cutting of thick-walled parts as well as micromachining of very thin walled plates through fusion. Lasers are also commonly used in additive processes, lithography-based or sintering-based, for the solidification of liquids and powders. Naturally, the types of lasers used in these applications are quite varied.\nChemicalmachining,alsoknownasetching, refers to the removal of material from metal surfaces through purely chemical reactions. It can favorably be used in etching shallow depths (or holes) in metals such as aluminum, titanium, and copper, which are vulnerable to erosion by certain chemicals (most notably hydrochloric, nitric, and sulphuric acids). Due to difficulties in focusing on small areas, most chemical processes use chemical-resistant masks to protect surfaces from unwanted etching.\nAll above-mentioned modern material removal or material additive processes are characterized by the following common features: higher power consumption and lower material removal (or additive) rates than traditional fabrication processes, but yielding better surface finish and integrity (i.e., less residual stress and fewer microcracks). A large number of these processes also are capable of fabricating features with dimensions several orders of magnitude less than those obtainable by traditional processes.", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/products/secondary-antibodies/goat-rabbit-igg-hl-biotin-preadsorbed-ab7089.html", "date": "2023-05-30T18:07:37Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-23/segments/1685224646076.50/warc/CC-MAIN-20230530163210-20230530193210-00652.warc.gz", "language_score": 0.7285855412483215, "token_count": 1029, "dump": "CC-MAIN-2023-23", "global_id": "webtext-fineweb__CC-MAIN-2023-23__0__268074431", "lang": "en", "text": "Goat Anti-Rabbit IgG H&L (Biotin) preadsorbed (ab7089)\nKey features and details\n- Goat Anti-Rabbit IgG H&L (Biotin) preadsorbed\n- Conjugation: Biotin\n- Host species: Goat\n- Suitable for: ICC/IF, WB, ELISA, Immunomicroscopy, Dot blot, IHC-P, IHC-Fr\nProduct nameGoat Anti-Rabbit IgG H&L (Biotin) preadsorbed\nSee all IgG secondary antibodies\nTested applicationsSuitable for: ICC/IF, WB, ELISA, Immunomicroscopy, Dot blot, IHC-P, IHC-Frmore details\nChicken, Cow, Goat, Guinea pig, Hamster, Horse, Human, Mouse, Rat, SheepTo ensure minimal cross-reactivity, the antibody has been pre-adsorbed with serum proteins from the following species.more details\nFull length native Rabbit IgG (purified).\nStorage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.\nStorage bufferPreservative: 0.01% Sodium azide\nConstituents: 0.42% Potassium phosphate, 0.87% Sodium chloride, 1% BSA\nConcentration information loading...\nPurification notesThis product was prepared from monospecific antiserum by immunoaffinity chromatography using Rabbit IgG coupled to agarose beads followed by solid phase adsorption(s) to remove any unwanted reactivities.\nConjugation notesBiotinamidocaproate N-Hydroxysuccinimide Ester (BAC) Biotin/Protein Ratio: 10-20 BAC molecules per Goat IgG molecule\nThe Abpromise guarantee\nOur Abpromise guarantee covers the use of ab7089 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\nELISA: 1/10000 - 1/40000.\nIHC-P: Use at an assay dependant dilution.\nIHC-Fr: Use at an assay dependant dilution.\nIM: Use at an assay dependant dilution.\nWB: Use at an assay dependant dilution.\nNot tested in other applications.\nOptimal dilutions/concentrations should be determined by the end user.\nTo our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.\nDatasheets and documents\nab7089 has been referenced in 5 publications.\n- Ling B et al. Nucleolar and spindle-associated protein 1 promotes non-small cell lung cancer progression and serves as an effector of myocyte enhancer factor 2D. Oncol Rep 45:1044-1058 (2021). PubMed: 33650655\n- Xu M et al. Blockage of C-X-C Motif Chemokine Receptor 2 (CXCR2) Suppressed Uric Acid (UA)-Induced Cardiac Remodeling. Front Physiol 12:700338 (2021). PubMed: 34385934\n- Guan X et al. Long non-coding RNA PCAT6 promotes the development of osteosarcoma by increasing MDM2 expression. Oncol Rep 44:2465-2474 (2020). PubMed: 33125146\n- Kim DH et al. Direct visualization of single-molecule membrane protein interactions in living cells. PLoS Biol 16:e2006660 (2018). PubMed: 30543635\n- Tan JY et al. Cross-talking noncoding RNAs contribute to cell-specific neurodegeneration in SCA7. Nat Struct Mol Biol 21:955-61 (2014). WB . PubMed: 25306109", "domain": "chemistry", "round": 3} +{"url": "https://hsp90-inhibitor.com/although-mitochondrial-respiration-is-reduced-in-most-cancer-cells-the-role/", "date": "2022-07-04T05:29:04Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-27/segments/1656104354651.73/warc/CC-MAIN-20220704050055-20220704080055-00513.warc.gz", "language_score": 0.9207414984703064, "token_count": 1209, "dump": "CC-MAIN-2022-27", "global_id": "webtext-fineweb__CC-MAIN-2022-27__0__99843076", "lang": "en", "text": "Although mitochondrial respiration is reduced in most cancer cells, the role of this reduce in cancer and carcinogenesis progression is still unclear. of mitochondrial indicators, total respiration was not altered. Nevertheless, respiratory coupling, and ATP amounts had been. Our data present that by raising the performance of the mitochondrial oxidative phosphorylation program, cancer tumor development is hampered by lowers in cell invasiveness and growth. check. Distinctions had been regarded significant when and (Bastin et?al., 2008, 2008, [Hyperlink]). It was reported that for fibroblasts, 400?Meters bezafibrate promoted the best increase in OXPHOS enzyme activities in 72?l without getting toxic to cells (Bastin et?al., 2008). As a result, we utilized a regular 400?Meters bezafibrate dosage in the experiments described below. Control cells had been treated with the same quantity of the automobile (DMSO) just. We verified the elevated reflection of PGC\\1 upon bezafibrate treatment (Amount?1A) seeing that good seeing that an boost in OXPHOS indicators (Amount?1B). Treatment with bezafibrate do not really have got a recognizable impact on the morphology or the distribution of mitochondria 955365-80-7 supplier in the cell (Amount?1C and data not shown). In addition to OXPHOS elements, the known amounts of Tim23 and TFAM, two mitochondrial indicators of internal matrix and membrane layer respectively, had been elevated in all the cell lines (Amount?1D). 955365-80-7 supplier Appropriately, the known amounts of mtDNA, sized as proportions to the nuclear DNA, had been also elevated in the cancers cell lines (Amount?1E). Amount 1 Bezafibrate induce PGC\\1 and OXPHOS elements in cultured cells. A, True\\period PCR perseverance of PGC\\1 transcript amounts from cDNAs from 143B and HeLa cells. C, West mark displaying the continuous\\condition 955365-80-7 supplier … The activities of mitochondrial enzymes were increased after bezafibrate treatment also. We sized the actions of a Krebs routine enzyme (citrate synthase, CS), unwanted fat acid solution catabolism (carnitine palmitoyl transferases, CPT\\I and CPT\\II) and oxidative phosphorylation (cytochrome oxidase, COX), all of which had been considerably elevated in bezafibrate\\treated cells (Amount?2AClosed circuit). Amount 2 Bezafibrate increases oxidative phosphorylation in cultured cells. A and C, Citrate synthase (CS) and Cytochrome c oxidase (COX) activity in bezafibrate\\ and DSMO\\treated cells (d?=?3 and pubs represent SD). C, carnitine … 3.2. Bezafibrate boosts ATP amounts and mitochondrial coupling Structured on the above proof displaying that bezafibrate upregulated OXPHOS elements in cancers cells, we investigated the energy status of the cells then. We discovered that bezafibrate\\treated cells acquired higher ATP amounts (Amount?3A). Nevertheless, despite the boost in mitochondrial elements and ATP amounts we discovered that bezafibrate treatment do not really have an effect on total cell breathing, sized as air intake in a Seahorse XF96 analyzer and an Oroboros O\\2k high quality respirometer (Amount?3B and data not shown). This obvious disparity was solved by calculating CCCP\\uncoupled breathing in Oroboros O\\2k, which demonstrated that mitochondria from bezafibrate\\treated cells had been better combined than in control cells (Amount?3C). In various other words and phrases, with the same level of electron transportation and air intake also, a more powerful proton electrochemical lean could end up being produced, even more traveling ATP activity through composite Sixth is v effectively. To confirm a vital conjecture of this speculation we also sized the mitochondrial membrane layer potential (meters) in these cells by the subscriber base and preservation of TMRE using FACS evaluation. In contract with the tighter coupling speculation, bezafibrate\\treated HeLa cells demonstrated a significant boost in CCCP\\delicate meters, while there was also a development for boosts in 143B and MDA\\MB\\231 cells (Amount?3D). Although the romantic relationship between meters and amounts of ROS is normally debatable (MacLellan et?al., 2005), a lower was discovered by us in the Rabbit Polyclonal to ADORA1 price of L2O2 in bezafibrate\\treated cells, as driven by Amplex Crimson (Amount?3E). Amount 3 Bezafibrate treatment boosts mobile ATP amounts by improving breathing coupling. A, Cellular ATP amounts of bezafibrate\\ and DMSO\\treated cells (n?=?6 and pubs represent SD). C, Endogenous breathing in different … 3.3. Elevated mitochondrial biogenesis decreases cell development in blood sugar mass media We following researched how this change toward oxidative fat burning capacity impacted cell development. Cells had been grown up in either blood sugar moderate or in galactose moderate. Galactose is normally digested extremely 955365-80-7 supplier through glycolysis and creates very much much less ATP likened to blood sugar gradually, needing a more solid OXPHOS and in 955365-80-7 supplier total will hence.\n- Domestic cats are commonly affected by viral pathogens that induce lengthy\n- The pituitary adenylate cyclase-activating polypeptide (PACAP) is a trophic factor that", "domain": "chemistry", "round": 3} +{"url": "https://gluethings.com/does-loctite-power-grab-harden/", "date": "2024-02-28T07:12:21Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707947474697.2/warc/CC-MAIN-20240228044414-20240228074414-00003.warc.gz", "language_score": 0.8722502589225769, "token_count": 4212, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__95164849", "lang": "en", "text": "Welcome to our blog post, where we’ll dive into the awesome world of Loctite Power Grab Hardener. If you’ve ever tackled home improvement or DIY repairs, you know that finding a reliable adhesive is key. And that’s where Loctite Power Grab Hardener steps in.\nLoctite Power Grab Hardener is no ordinary glue. It’s a heavy-duty adhesive that packs a serious punch. This stuff can bond just about anything – wood, metal, ceramics, concrete – you name it.\nBut what sets Loctite Power Grab Hardener apart from the rest? Well, for starters, it’s lightning fast and super easy to use. No need to wait around for hours while your project dries or clamp everything together like a mad scientist. With this adhesive, you get immediate strength and stability.\nAnd let’s talk about durability. Loctite Power Grab Hardener means business. It can handle heavy loads and extreme conditions without breaking a sweat. Water? No problem. Temperature changes? Piece of cake. Impact? Bring it on. This adhesive laughs in the face of challenges.\nSo how can you put this bad boy to work? The possibilities are endless. Whether you’re jazzing up your woodworking game, fixing up household items, or working on a construction site, Loctite Power Grab Hardener is your trusty sidekick. It’ll secure baseboards and crown molding with ease, install ceramic tiles like a pro, and keep metal brackets locked in place.\nTo sum it all up, Loctite Power Grab Hardener is the bomb dot com when it comes to adhesives. It’s fast, strong, and versatile – everything you need in one little tube. So stay tuned for more blog posts where we’ll dig deeper into all the nitty-gritty details of using Loctite Power Grab Hardener like a boss.\nWhat is the Purpose of Loctite Power Grab?\n- 1 What is the Purpose of Loctite Power Grab?\n- 2 How Does Loctite Power Grab Work?\n- 3 The Curing Process of Loctite Power Grab\n- 4 Factors Affecting the Curing Time of Loctite Power Grab\n- 5 Materials Suitable for Use with Loctite Power Grab\n- 6 Proper Application and Usage of Loctite Power Grab\n- 7 Advantages of Using Loctite Power Grab\n- 8 Disadvantages of Using Loctite Power Grab\n- 9 Conclusion\nWhen it comes to construction projects or DIY endeavors, having a reliable adhesive is essential. Loctite Power Grab has become a go-to solution for many enthusiasts and professionals alike due to its purposeful design and impressive performance. In this blog post, we will explore the various aspects of Loctite Power Grab and why it is loved by users worldwide.\nQuick and Secure Bonding:\nLoctite Power Grab is specifically engineered to provide a strong and secure bond quickly. Its high initial grab ensures that objects stay in place immediately after application, eliminating the need for additional support like nails or screws. This feature makes it an excellent choice for tasks such as installing trim or molding.\nDurability in Various Conditions:\nThe purpose of Loctite Power Grab extends beyond just quick bonding. Once cured, this adhesive forms a durable bond that can withstand everyday stresses and strains. It boasts excellent resistance to moisture, enabling it to maintain its integrity even in wet or humid conditions. Whether you’re working indoors or outdoors, you can trust Loctite Power Grab to hold up.\nVersatility in Application:\nLoctite Power Grab offers versatility in its application, making it suitable for a wide range of materials and surfaces. It adheres well to both porous and non-porous surfaces, expanding its potential uses. Additionally, its unique gel-like consistency prevents dripping or running, allowing for easy application on vertical surfaces without the need for clamping.\nConvenient and Efficient Solution:\nOne of the primary purposes of Loctite Power Grab is to provide a convenient and efficient adhesive solution for DIY projects and construction jobs. Its quick bonding capabilities save time and effort, while also ensuring a reliable bond between materials.\nHow Does Loctite Power Grab Work?\nThis high-strength adhesive is known for its durability, versatility, and convenience, making it a popular choice among professionals and hobbyists alike.\nOne of the standout features of Loctite Power Grab is its fast initial grab. Once applied to a surface, it immediately starts to bond, eliminating the need for drying or setting time. This time-saving feature allows you to move on to the next steps of your project without delay.\nLoctite Power Grab’s ability to work on vertical surfaces without additional support or clamping is another impressive attribute. Its strong adhesion and unique formula make it possible to confidently apply the adhesive on walls, ceilings, or other vertical surfaces, knowing it will hold securely in place.\nWhat sets Loctite Power Grab apart from other adhesives is its durability. The adhesive contains polymers that create a flexible bond, enabling it to absorb shocks and vibrations. This makes it ideal for applications involving movement or stress, whether you’re working on a construction project or repairing your car.\nIn terms of versatility, Loctite Power Grab excels at bonding a wide range of materials. Wood, metal, concrete, plastics – you name it, Loctite Power Grab can handle it. Its fillers increase viscosity and provide gap-filling properties, allowing effective bonding even on uneven or porous surfaces.\nUsing Loctite Power Grab is simple. Just apply the adhesive to one surface, press the two surfaces together firmly, and allow it to cure. Curing time can vary depending on temperature and humidity but typically ranges from 24 to 48 hours for full strength. It’s essential to test Loctite Power Grab on a small area before applying it to larger surfaces to ensure compatibility.\nThe Curing Process of Loctite Power Grab\nIn this blog post, we will dive into the captivating world of Loctite Power Grab and explore the intricate details of its curing process. Get ready to uncover the secrets behind this adhesive superhero.\nThe Chemistry Behind the Cure:\nLoctite Power Grab’s curing process is an enchanting chemical reaction between the adhesive and the moisture in the air. As soon as it is exposed to the air, the adhesive embarks on a journey of transformation, gradually curing and hardening over time.\nBut what sets this adhesive apart from others? Loctite Power Grab is a solvent-based adhesive, brimming with volatile solvents that gracefully evaporate during the curing process.\nThis unique composition allows for even spreading and deep penetration into the substrate, creating a bond that is nothing short of extraordinary.\nStages of Curing:\nThe curing process of Loctite Power Grab can be divided into different stages, each unveiling a new facet of its power. Initially, when applied, the adhesive takes on a liquid or semi-liquid form, granting you the ability to effortlessly adjust and position the bonded surfaces. As the solvents begin their ethereal dance in the air, they gradually evaporate, leaving behind a tacky residue that signals the adhesive’s initial strength. With time, as the curing process continues its mesmerizing course, the adhesive undergoes a remarkable metamorphosis, progressively hardening until it reaches its final state of strength.\nFactors Affecting Curing Time:\nThe magical transformation of Loctite Power Grab is influenced by various factors that ultimately determine its curing time. Temperature, humidity, and even the thickness of the applied adhesive all play their part in this captivating dance. Generally, one must exercise patience and allow approximately 24 hours for the adhesive to fully cure and unveil its maximum strength. Yet, it is important to note that appearances can be deceiving, as the adhesive may feel dry to the touch after a few hours, but true mastery takes time.\nProper Surface Preparation:\nTo ensure the successful culmination of the curing process, proper surface preparation is of utmost importance. The surfaces must undergo a thorough cleansing ritual, free from any contaminants such as dust, grease, or oil. Only then can they become a blank canvas for Loctite Power Grab’s artistic touch. For smoother surfaces, a gentle roughening or sanding can enhance the adhesive’s bonding prowess. As always, it is essential to consult the manufacturer’s instructions for specific recommendations regarding compatibility with different substrates.\nFactors Affecting the Curing Time of Loctite Power Grab\nLoctite Power Grab adhesive possesses a remarkable ability to create extraordinary connections. In this article, we embark on a journey to unravel the secrets behind its curing time, peeling back the layers of this captivating process. So, let’s dive into the enchanting world of Loctite Power Grab and explore the factors that influence its curing time.\nTemperature: Igniting the Flames of Transformation\nThe temperature of the environment wields significant power over the curing time of Loctite Power Grab. Like a magical catalyst, higher temperatures breathe life into its transformative abilities, while lower temperatures slow it down. For optimal results, apply the adhesive within a temperature range of 50°F to 100°F. Extreme temperatures below 40°F or above 100°F can disrupt the bonding performance and extend the curing time.\nHumidity: Balancing the Waters of Progress\nHumidity levels in the air also sway the curing time of Loctite Power Grab. Higher humidity drips with patience, slowing down the curing process, while lower humidity quickens its pace. Before applying the adhesive, consider the ambient moisture levels. In areas with high humidity, prepare for a lengthier wait as it takes more time for the adhesive to cure completely.\nSubstrate Material: The Foundation of Bonding\nThe type and condition of the substrate material being bonded can influence how long it takes for Loctite Power Grab to cure. Porous or absorbent surfaces, like wood or concrete, demand more time to solidify compared to non-porous surfaces like metal or glass. Additionally, a dirty or contaminated surface hampers bonding and extends curing time. Prepare your surfaces meticulously for a triumphant bond.\nThickness: The Artistry of Layers\nThe thickness of the adhesive layer applied also dances with the curing time. Thin layers pirouette with speed, while thicker ones waltz at a slower pace. Follow the manufacturer’s guidelines regarding thickness to achieve optimal bonding and curing results.\nMixing and Application Techniques: Conducting the Symphony of Success\nProper mixing and application techniques compose the melodious symphony of optimal curing results with Loctite Power Grab. Harmonize the adhesive through thorough mixing before applying it, ensuring uniformity and activating vital chemical reactions. Apply the adhesive evenly, avoiding excessive or insufficient amounts that can impact curing time.\nPresence of Air: Eliminating the Dance of Disturbance\nThe presence of air orchestrates its influence over the curing time of Loctite Power Grab. Remove trapped air bubbles or pockets during the application process to ensure a seamless performance. Apply adequate pressure or clamping to eliminate air gaps and promote efficient curing.\nMaterials Suitable for Use with Loctite Power Grab\nLoctite Power Grab is a versatile adhesive that can bond a wide range of materials, making it the go-to choice for all your bonding needs. Whether you’re working with wood, concrete, metal, glass, or plastic, Loctite Power Grab has got you covered.\nLet’s start with porous materials. Loctite Power Grab works like magic on surfaces like wood, concrete, and stone. These materials have rough surfaces that provide the perfect grip for the adhesive, resulting in a strong and durable bond. So whether you’re sticking two pieces of wood together or repairing a cracked concrete surface, Loctite Power Grab is the ideal adhesive for the job.\nBut what about non-porous materials? Don’t worry, Loctite Power Grab can handle those too. However, it’s important to note that these surfaces may require some preparation before applying the adhesive. For example, metal surfaces may need to be cleaned and roughened with sandpaper to improve adhesion. And when it comes to plastic surfaces, not all plastics are created equal. Some plastics, like polyethylene and polypropylene, have low surface energy and can be more difficult to bond with adhesives. In these cases, using a primer or opting for a specialized adhesive designed for these plastics might be necessary.\nLastly, it’s important to consider the weight and stress that will be placed on the bonded materials. While Loctite Power Grab is strong and durable, it’s always a good idea to test the bond strength before subjecting the materials to heavy loads or excessive stress. This will ensure that your bond holds up over time and keeps everything securely in place.\nProper Application and Usage of Loctite Power Grab\nLoctite Power Grab adhesive is a versatile product that can work wonders when it comes to bonding different materials together. Whether you’re a DIY enthusiast or a professional contractor, understanding the proper application and usage of this adhesive is essential for achieving optimal results.\nIn this guide, we will walk you through the step-by-step process of using Loctite Power Grab, from surface preparation to curing, and provide tips for maximizing its bonding capabilities.\nStep 1: Surface Preparation\n- Clean surfaces thoroughly, removing dirt, dust, grease, or other contaminants.\n- Dry the surfaces completely before applying the adhesive.\n- A clean surface enhances bond strength and longevity.\nStep 2: Application\n- Use a caulk gun or adhesive dispenser for controlled and precise application.\n- Apply a thin, even layer of Loctite Power Grab to one surface.\n- Avoid applying too much adhesive to prevent messy squeeze-out.\n- Less is more – aim for a solid but controlled application.\nStep 3: Bonding\n- Immediately press the two surfaces together after applying the adhesive.\n- Ensure proper alignment for an even bond.\n- Apply constant pressure for a few minutes to maximize contact between surfaces.\n- Firmly hold bonded materials in place using clamps or weights.\nStep 4: Curing\n- Curing time varies based on temperature and humidity – check product instructions.\n- Avoid movement or stress on bonded materials during curing.\n- Keep materials stationary for at least 24 hours after application.\n- This allows for proper curing and maximum bond strength.\nStep 5: Material Suitability\n- Loctite Power Grab works on porous and non-porous surfaces like wood, metal, concrete, ceramic, and some plastics.\n- Test adhesive on a small area to ensure compatibility before applying to the entire surface.\nStep 6: Storage\n- Store Loctite Power Grab in a cool, dry place to maintain effectiveness.\n- Extreme temperatures and moisture can affect performance and shelf life.\n- Tightly seal the container after each use to prevent air and moisture from entering.\nAdvantages of Using Loctite Power Grab\nLook no further. Loctite Power Grab is here to save the day with its super strength and versatility. Whether you’re a DIY enthusiast or a professional contractor, this adhesive is your go-to solution for all bonding projects. Let’s explore the amazing advantages of using Loctite Power Grab.\nLoctite Power Grab is a true superhero when it comes to bonding. Its specially formulated formula ensures a strong and durable connection between different surfaces, such as wood, metal, and plastic. Say goodbye to weak bonds and hello to a bond that can withstand the test of time.\nVersatility at its Best:\nThis adhesive is like a chameleon – it can adapt to various applications effortlessly. From installing crown molding and baseboards to bonding drywall, mirrors, and even heavy objects like cabinets, Loctite Power Grab does it all. It’s the ultimate sidekick for both professionals and DIY enthusiasts.\nTime is on Your Side:\nWith Loctite Power Grab, you don’t have to play the waiting game. Its quick drying time allows you to continue with your project in no time. Say goodbye to long hours of waiting for the adhesive to harden completely. This time-saving feature increases efficiency and keeps you on schedule.\nNo More Clamps Needed:\nForget about struggling with clamps or additional support during the curing process. Loctite Power Grab’s high initial grab strength eliminates the need for these extra tools. Your materials will stay in place without any external assistance – talk about convenience.\nApplying Loctite Power Grab is as easy as pie. Its user-friendly formulation makes the process a breeze. The adhesive comes in a tube or cartridge with a precise nozzle, ensuring clean and neat application. No more messy spills or excessive dripping. Plus, cleaning up excess adhesive is a piece of cake with just water.\nLoctite Power Grab isn’t just about strength; it’s also about beauty. Once fully cured, this adhesive is paintable and sandable. You can seamlessly blend the bonded surfaces with the surrounding area, achieving a flawless finish. It’s the perfect adhesive for both functional and visually appealing projects.\nMother Nature Approved:\nLoctite Power Grab is designed to withstand the forces of nature. It laughs in the face of temperature fluctuations, humidity, and even direct sunlight. This weather resistance ensures that your bond remains intact over time, providing long-term durability and reliability.\nDisadvantages of Using Loctite Power Grab\nLoctite Power Grab, a popular adhesive used for various applications, may seem like a dream come true with its quick grab and initial tackiness. However, it’s important to consider the potential drawbacks before diving into your next project.\nFirstly, Loctite Power Grab has limited bond strength compared to other heavy-duty adhesives. While it may hold up initially, it may not provide the strong and long-lasting bond required for certain projects.\nCompatibility is another concern. Loctite Power Grab may not adhere well to surfaces such as plastics or low-energy materials like polyethylene or polypropylene. Checking compatibility before application is crucial to avoid disappointment.\nCuring time is another disadvantage. Unlike some quick-drying adhesives, Loctite Power Grab may require a longer curing time. This can be frustrating for time-sensitive projects or when immediate bonding is needed.\nRemoving or repositioning bonded items can be challenging with Loctite Power Grab. Once cured and hardened, it becomes nearly impossible to separate two bonded items. This can be problematic if adjustments or repairs are necessary after the adhesive has set.\nTemperature resistance is an area where Loctite Power Grab falls short. It may not withstand extreme heat or cold conditions, leading to a decrease in bond strength or even adhesive failure. Using this adhesive in extreme environments may require reconsideration.\nVentilation concerns also arise with Loctite Power Grab. Some users have reported a strong odor when using this adhesive, which can be unpleasant and potentially harmful if used in poorly ventilated areas. Proper ventilation or protective gear is necessary to mitigate these concerns.\nLastly, cost can be a disadvantage. Loctite Power Grab tends to be pricier compared to other adhesives on the market. This can pose a challenge for those on a tight budget or for larger projects that require a significant amount of adhesive.\nThe conclusion is clear: Loctite Power Grab does indeed harden.\nThis adhesive lives up to its name, delivering a powerful hold that solidifies over time. Once applied, you can trust that your project will stay firmly in place.\nDon’t let the word “grab” fool you – this product goes beyond grabbing, it firmly grips and sets like a vice. Whether you’re working on a small DIY project or tackling a major construction job, Loctite Power Grab will provide the strength and durability you need.\nSay goodbye to worries about things coming loose or falling apart – with this adhesive, your work will stand the test of time.", "domain": "chemistry", "round": 3} +{"url": "https://positivemindstuitionacademy.com/qa/quick-answer-how-can-i-reduce-acid-in-my-body-naturally.html", "date": "2020-11-24T06:46:56Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-50/segments/1606141171126.6/warc/CC-MAIN-20201124053841-20201124083841-00554.warc.gz", "language_score": 0.8804599046707153, "token_count": 976, "dump": "CC-MAIN-2020-50", "global_id": "webtext-fineweb__CC-MAIN-2020-50__0__146928488", "lang": "en", "text": "- How do I reduce the acidity in my body?\n- What foods reduce acid in your body?\n- What are the signs of too much acid in your body?\n- Is coffee acidic or alkaline?\n- What causes excess stomach acid?\n- What foods are high in acid?\n- How can I increase acidity in my body?\n- How do I know if my body is acidic?\n- How can I reduce acidity without medicine?\n- How can I Alkalize my body quickly?\n- What can I drink to reduce acid in my body?\nHow do I reduce the acidity in my body?\nPopular replies (1)Get a physical health exam and pH test.Take a sodium bicarbonate solution.Drink water and electrolyte-containing beverages.Eat vegetables such as spinach, broccoli and beans or fruits such as raisins, bananas and apples are appropriate choices for neutralizing body pH.More items….\nWhat foods reduce acid in your body?\nFoods that may help reduce your symptomsVegetables. Vegetables are naturally low in fat and sugar, and they help reduce stomach acid. … Ginger. … Oatmeal. … Noncitrus fruits. … Lean meats and seafood. … Egg whites. … Healthy fats.\nWhat are the signs of too much acid in your body?\nWhen your body fluids contain too much acid, it’s known as acidosis. Acidosis occurs when your kidneys and lungs can’t keep your body’s pH in balance….Some of the common symptoms of respiratory acidosis include the following:fatigue or drowsiness.becoming tired easily.confusion.shortness of breath.sleepiness.headache.\nIs coffee acidic or alkaline?\nWhile our bodies have a pH value of 7.4 (around neutral), tap water 6.5-8.5, coffee is typically around pH 4.3-5, which is mildly acidic. Typically any food or beverage more acidic than our own body chemistry can trigger digestive discomfort, inflammation and “burning” side-effects like acid reflux or heartburn.\nWhat causes excess stomach acid?\nThere are several causes of high stomach acid. Examples include H. pylori infection, Zollinger-Ellison syndrome, and rebound effects from medication withdrawal. If left untreated, high stomach acid can lead to complications like ulcers or GERD.\nWhat foods are high in acid?\nHigh-acid food and drinkgrains.sugar.certain dairy products.fish.processed foods.fresh meats and processed meats, such as corned beef and turkey.sodas and other sweetened beverages.high-protein foods and supplements.\nHow can I increase acidity in my body?\n5 ways to improve stomach acidLimit processed foods. A balanced diet rich in fruits and vegetables can also increase your stomach acid levels. … Eat fermented vegetables. Fermented vegetables — such as kimchi, sauerkraut, and pickles — can naturally improve your stomach acid levels. … Drink apple cider vinegar. … Eat ginger.\nHow do I know if my body is acidic?\nUrine tests measure the level of acid in the body. Optimal pH levels are between 6.5 and 7.5. When the pH level is lower than 6.5, the body is considered acidic and when the pH level is higher than 7.5, the body is considered alkaline.\nHow can I reduce acidity without medicine?\nIf you’ve been having repeated episodes of heartburn—or any other symptoms of acid reflux—you might try the following:Eat sparingly and slowly. … Avoid certain foods. … Don’t drink carbonated beverages. … Stay up after eating. … Don’t move too fast. … Sleep on an incline. … Lose weight if it’s advised. … If you smoke, quit.More items…•\nHow can I Alkalize my body quickly?\nTo find a healthy lifestyle balance, your diet should consist of 80 per cent alkaline forming foods and 20 per cent acid forming foods. The list includes fruits, vegetables, nuts, herbs, herbal teas, seeds, green juice, melons, lemons and seeds are some of the best alkaline foods.\nWhat can I drink to reduce acid in my body?\ndrinks to reduce acidity, low acidity drinksMint Chaas, Punjabi Mint Chaas Recipe.Date and Banana Shake.Papaya and Green Apple Smoothie.Saffron Cardamom Almond Milk, Healthy Vegan Breakfast Recipe.Ginger Cinnamon Tea.Fresh Mint and Lemon Tea.", "domain": "chemistry", "round": 3} +{"url": "https://www.intechopen.com/profiles/216083", "date": "2022-05-17T05:16:49Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-21/segments/1652662515501.4/warc/CC-MAIN-20220517031843-20220517061843-00393.warc.gz", "language_score": 0.9434995055198669, "token_count": 270, "dump": "CC-MAIN-2022-21", "global_id": "webtext-fineweb__CC-MAIN-2022-21__0__68318283", "lang": "en", "text": "Nanofiber has attracted increasing attention owing to its wide applications such as filtration, drug delivery, wound dressing, separator, etc. A lot of fabrication methods are developed in the last few decades, electrospinning method is the most frequently utilized method for producing nanofiber. However, electrospinning features a use of electrical field to produce nanofiber, which have obviously high production cost and a big burden on the environment. And several limitations are observed such as orientation of fibers and limited options of polymer and solvents, so many researchers try to develop more facile and more effective method for making nanofiber. In this chapter, recent developed fabrication methods, handspinning, direct writing, touch and brush spinning, are discussed and the advantages of each methods are described, respectively. They utilize a simple mechanical force instead of electrical force, which delivers great benefits to producing nanofiber such as orientation of fibers along with the force direction, reduction of every cost, availability of various options for selecting polymer and solvents, and a facility to design a pattern with high precision. Those innovative and novel methods will enable us to make functional nanofibers more effective than traditional methods; consequently, they will broaden the application of nanofibers.\nPart of the book: Novel Aspects of Nanofibers", "domain": "chemistry", "round": 3} +{"url": "https://innovareacademics.in/journals/index.php/ajpcr/article/view/37341", "date": "2021-04-11T22:36:02Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-17/segments/1618038065492.15/warc/CC-MAIN-20210411204008-20210411234008-00550.warc.gz", "language_score": 0.7661805152893066, "token_count": 1358, "dump": "CC-MAIN-2021-17", "global_id": "webtext-fineweb__CC-MAIN-2021-17__0__67531441", "lang": "en", "text": "EFFICACY OF EUPHORBIA HETEROPHYLLA LATEX AGAINST PATHOGENIC BACTERIA AND FUNGI\nObjective: The objective of the study was to determine the antimicrobial activities of Euphorbia heterophylla latex.\nMethods: The antibacterial and antifungal activities of acetone, chloroform, and diethyl ether extracts were assayed by disk diffusion method.\nResults: The study of plant E. heterophylla latex revealed the presence of medically active metabolites. Bacterial strains such as Staphylococcus aureus, Bacillus subtilis, Proteus vulgaris, and Pseudomonas aeruginosa exhibited a strong zone of inhibition. Acetone extract exerts a potent zone of inhibition against P. aeruginosa compared to tetracycline. Fungi, Aspergillus niger, Fusarium oxysporum, and Penicillium sp., were used for the antifungal activity. It was observed that the highest zone of inhibition was noticed against A. niger in all the extracts. Interestingly, F. oxysporum and Penicillium sp. showed no zone of inhibition and were resistant to standard drug, fluconazole which was used as a control.\nConclusion: E. heterophylla latex extract was found to be more potent than the standard drugs which were used against both the bacterial and fungal strains.\n2. Latif A, Almad H, Begun S, Adnan M, Hussain WM. Medicinal and Other Economic Plant as Substitute to Forest Logging in Miandam and Sulatat Valleys, Swat. Pakistan: Proceedings of International Workshop on Conservation and Sustainable Use of Medicinal and Aromatic Plants in Pakistan; 2003. p. 101-5.\n3. Shinwari ZK, Pehman M, Watanabe T, Yoshikawa T. A Pictorial Guide to Medicinal Plants of Pakistan. Kohat: Kohat University of Science and Technology; 2006.\n4. Hoffman PC, Combs DK, Caster MD. Performance of lactating dairy cows fed alfalfa silage or perennial ryegrass silage. J Dly Sci 1998;81:162-8.\n5. Mathews CE, Vanholds KE, Ahem KG. Biochemistry. 3rd ed. United States: Benjamin Cummings; 1999.\n6. Dingman SL. Water in soils: Infiltration and redistribution. In: Physical Hydrology. 2nd ed. Upper Saddle River, New Jersey: Prentice-Hall, Inc.; 2002. p. 646.\n7. Difuntorum YS, Touami S. In vitro antimicrobial activity of GSQ1530, a new heteroaromatic polycyclic compound. Antimicrob Agents Chemother 2002;46:3168-74.\n8. Nair R, Chanda S. Anticandidal activity of Punica granatum exhibited in different solvents. Pharm Biol 2005;43:21-25.\n9. Mary S, Mahesh MK. Antimicrobial activity of Asclepias curassavica flower extract. J BioInnov 2014;3:261-8.\n10. Latif A, Almad H, Begun S, Adnan M, Hussain WM. Medicinal and Other Economic Plant as Substitute to Forest Logging in Miandam and Sulatat Valleys, Swat. Pakistan: Proceedings of International Workshop on Conservation and Sustainable Use of Medicinal and Aromatic Plants in Pakistan; 2003. p. 101-5.\n11. Adnan M, Holscher D. Medicinal plant abundance in degraded and reforested sites in Northwest Pakistan. Mt Res Dev 2010;30:25-32.\n12. Omale J, Emmanuel F. Phytochemical composition, bioactivity and wound healing potential of Euphorbia heterophylla (Euphorbiaceae) leaf extract. Int J Pharm Biomed Res 2010;1:54-63.\n13. Jaiyesimi AA, Abo A. Phytochemical and antimicrobial analysis of the crude extract, petroleum ether and chloroform fractions of Euphorbia heterophylla L whole plant. Pharmacogn J 2010;2:1-4.\n14. Hartwell JL. Plants used against cancer. A survey. Lloydia 1969;32:247-96.\n15. Okeniyi SO, Adedoyin BJ, Garba S. Phytochemical screening, cytotoxicity, antioxidant and antimicrobial activities of stem and leave extracts of Euphorbia heterophylla. J Biol Life Sci 2013;4:2157-6076.\n16. Ughachukwu PO, Ezenyeaku CC, Ochiogu BC, Ezeagwuna DA, Anahalu IC. Evaluation of antibacterial activities of Euphorbia heterophylla. IOSR J Dent Med Sci 2014;13:69-75.\n17. Essawi T, Srour M. Screening of some Palestinian medicinal plants for antibacterial activity. J Ethnopharmacol 1999;70:343-9.\n18. Okeke IN, Laxmaninaraya R, Bhutta ZA, Duse AG, Jenkins P, O’Brien TF, et al. Antimicrobial resistance in developing countries. Part I: Recent trends and current status. Lancet Infect Dis 2005;5:481-93.\n19. Harborne JB. Phytochemical Methods. London: Chapman and Hall Ltd.; 1973. p. 49-188.\n20. Bauer A, Kirby WM, Sherris JC, Truck M. Antibiotic susceptibility testing by a standardized single disk method. Am J Clin Pathol 1966;36:493-6.\n21. Freeman BC, Beattle GA. An overview of plant defenses against pathogens and herbivores. Plant Health Instr 2008. DOI: 10.1094/PHI-I-2008-0226-01.\n22. Xiao-Tian L, Wei-Shuo F. Medicinal Chemistry of Bioactive Natural Products. Hoboken: John Wiley and Sons, Inc.; 2006.\nThis work is licensed under a Creative Commons Attribution 4.0 International License.\nThe publication is licensed under CC By and is open access. Copyright is with author and allowed to retain publishing rights without restrictions.", "domain": "chemistry", "round": 3} +{"url": "https://gentaur.com/4223132987/leptomycin-b-for-cell-activation/biovision?p=1012196730", "date": "2021-11-30T02:33:22Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-49/segments/1637964358903.73/warc/CC-MAIN-20211130015517-20211130045517-00140.warc.gz", "language_score": 0.7340725064277649, "token_count": 363, "dump": "CC-MAIN-2021-49", "global_id": "webtext-fineweb__CC-MAIN-2021-49__0__79771776", "lang": "en", "text": "A potent, specific inhibitor of nuclear export signal (NES)-dependent protein export from the nucleus. It alkylates and inhibits CRM1 (chromosomal region maintenance)/exportin 1(XPO1), a protein required for nuclear export of proteins containing a nuclear export sequence . At low nM concentrations, Leptomycin B blocks the nuclear export of many proteins including HIV-1 Rev, MAPK/ERK, and NF-κB/IκB, and it stabilizes the expression of p53.\nLMB; Elactocin; Mantuamycin; CI-940; CL-1957A; PD-114720; ATS 1287B\n0.2 mg/ml (EtOH)\nIs this a salt?\nIs it cell-permeable?\n≥99% by HPLC\nMaximum time for storage\nProtect from air and light\nFor cells, cell lines and tissues in culture till half confluency.\nLeptomycin B for activation\nLeptomycin B to measure cellular activation", "domain": "chemistry", "round": 3} +{"url": "https://www.biopaqc.com/2018/09/28/background-hepatocellular-carcinoma-hcc-exhibits-solid-intrinsic-and-received-drug-resistance/", "date": "2024-04-18T18:08:47Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712296817222.1/warc/CC-MAIN-20240418160034-20240418190034-00853.warc.gz", "language_score": 0.9253126382827759, "token_count": 1189, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__1005884", "lang": "en", "text": "Background Hepatocellular carcinoma (HCC) exhibits solid intrinsic and received drug resistance which may be the primary obstacle to chemotherapy. research, we investigated the consequences of downstream MAPK pathway (Raf1 and MEK) inhibition on chemosensitivity aswell as MRP1 and MRP3 appearance in HCC. We proven that MEK inhibition sensitized HCC cells to gemcitabine and doxorubicin. And we additional indicated that downregulation of MRP1 and MRP3 by MEK inhibitors might lead partially to the sensitization. Continual cell proliferation is among the primary features of tumor and MAPK pathway can be involved with regulating cell proliferation . Raf1 or MEK inhibitor was reported to suppress HCC cells development [28-30]. Furthermore, mix of MEK inhibitor (AZD6244) and doxorubicin result in synergistic HCC tumor development inhibition in mouse versions . Consistent with prior investigations, our data demonstrated that monotherapy of either Raf1 inhibitor (GW5074) or MEK inhibitors (U0126 and AZD6244) exhibited a dose-dependent development inhibition of HCC cells. Furthermore, we noticed that Tmem34 pretreatment of MEK inhibitors sensitized HCC cells to doxorubicin or gemcitabine, and elevated intracellular doxorubicin deposition. Predicated on these outcomes, we hypothesized that additional cell development inhibition might result from elevated deposition of chemotherapeutic reagents in tumor cells. AZD6244, also called Selumetinib or ARRY-142886, was already tested in stage II scientific trial for hepatocellular carcinoma which indicated that AZD6244 got minimal single-agent activity despite proof suppression of focus on activation . Our outcomes suggested that mix of BIIB-024 AZD6244 with regular anticancer drugs could be an optional restorative choice. Desire to for the modulation of ABC BIIB-024 protein is to boost the effectiveness of anticancer medicines through raising intracellular anticancer medication build up . Abundant proof shows that tyrosine kinase inhibitors (TKIs) BIIB-024 could modulate ABC protein either in function or in mRNA and proteins level. Dohse et al. reported BIIB-024 that imatinib and dasatinib, which inhibit BCR-ABL tyrosine kinase, could overcome ABCG1 and ABCG2 transporting function . Comparable outcomes were from vandetanib (VEGFR and EGFR inhibitor) through practical inhibition of ABCB1, ABCC1 and ABCG2 [35,36]. And U0126 (MEK inhibitor) advertised PGP proteins degradation in colorectal malignancy was also reported . Earlier studies inside our group indicated that gefitinib (EGFR inhibitor) and sorafenib (VEGFR, PDGFR-h and Raf inhibitor) exerted inhibitory results on mRNA manifestation of ABCB1, ABCC1, ABCC2 and ABCC3 [16,21]. Our current outcomes indicated that MEK inhibitors reduced the endogenous MRP1 proteins expression, which added to intrinsic medication level of resistance in HCC . As previously reported, obtained drug resistance could possibly be induced by small amount of time chemotherapy, but last for a lot more than 6 weeks . In HCC, regular chemotherapy enabled cancers cells to obtain drug level of resistance through overexpression of MRP1 and MRP3. Nevertheless, MEK inhibitors considerably reversed the upregulation of MRP1 and MRP3 induced by gemcitabine and doxorubicin. Predicated on these data, we speculate that MEK inhibitors might invert both intrinsic and obtained drug level of resistance in HCC cells through inhibition of MRP1 and MRP3 proteins expression. As opposed to the down-regulation of MRP1 and MRP3 proteins expression, mRNA appearance was elevated following the U0126 treatment, specifically for MRP3 (data not really proven). Furthermore, U0126 also exerted an enhancive influence on ABCC3 mRNA upregulation induced by gemcitabine and doxorubicin, while MRP3 proteins expression was reduced after U0126 treatment. Dreuw et al. also reported equivalent outcomes, namely that publicity of U0126 to dermal fibroblasts improved ABCC3 mRNA appearance . The post transcriptional legislation may be in charge of this phenomenon. Through the use of pulse chase tests, Katayama et al. reported that U0126 marketed PGP degradation but didn’t influence its biosynthesis . Furthermore, it had been reported that MEK inhibitor could induce transcriptional upregulation of endogenous BCRP through the inhibition from the MEK-ERK-RSK pathway, but promote post-transcriptional proteins degradation of endogenous BCRP through the inhibition from the MEK-ERK-non-RSK pathway in breasts cancers cells . Additional experiments indicated the fact that 5 end from the ABCB1 mRNA in regular cancer of the colon cells was shorter than in doxorubicin resistant breasts cancers cells, and substitute promoters were in charge of the PGP post-transcriptional legislation, which exhibited elevated ABCB1 mRNA appearance but unchanged proteins appearance and PGP efflux function . Nevertheless, the mechanisms involved with post-transcriptional degradation of MRP1 and MRP3 need additional elucidation. MEK inhibitor exerted more powerful downregulatory influence on the endogenous MRP1 appearance than MRP3. The MRP1 appearance.", "domain": "chemistry", "round": 3} +{"url": "https://pdbj.org/emnavi/quick.php?id=pdb-2f38", "date": "2023-01-29T14:55:11Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-06/segments/1674764499744.74/warc/CC-MAIN-20230129144110-20230129174110-00254.warc.gz", "language_score": 0.6751601099967957, "token_count": 3096, "dump": "CC-MAIN-2023-06", "global_id": "webtext-fineweb__CC-MAIN-2023-06__0__225114040", "lang": "en", "text": "|Entry||Database: PDB / ID: 2f38|\n|Title||Crystal structure of prostaglandin F synathase containing bimatoprost|\n|Components||Aldo-keto reductase family 1 member C3|\n|Keywords||OXIDOREDUCTASE / Prostaglandin F synthase / AKR1C3 / PGF2alpha fromation / PGH2 / bimatoprost / catalytic mechanism|\n|Function / homology|\nFunction and homology information\nprostaglandin-F synthase / testosterone 17beta-dehydrogenase (NADP+) / prostaglandin D2 11-ketoreductase activity / ketoreductase activity / prostaglandin-F synthase activity / cellular response to prostaglandin stimulus / cellular response to corticosteroid stimulus / regulation of testosterone biosynthetic process / negative regulation of retinoic acid biosynthetic process / 3beta(or 20alpha)-hydroxysteroid dehydrogenase ...prostaglandin-F synthase / testosterone 17beta-dehydrogenase (NADP+) / prostaglandin D2 11-ketoreductase activity / ketoreductase activity / prostaglandin-F synthase activity / cellular response to prostaglandin stimulus / cellular response to corticosteroid stimulus / regulation of testosterone biosynthetic process / negative regulation of retinoic acid biosynthetic process / 3beta(or 20alpha)-hydroxysteroid dehydrogenase / 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity / 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+) / 5alpha-androstane-3beta,17beta-diol dehydrogenase activity / cellular response to prostaglandin D stimulus / delta4-3-oxosteroid 5beta-reductase activity / farnesol catabolic process / macromolecule metabolic process / geranylgeranyl reductase activity / 3alpha-hydroxysteroid 3-dehydrogenase / phenanthrene 9,10-monooxygenase activity / cellular response to jasmonic acid stimulus / 3alpha(or 20beta)-hydroxysteroid dehydrogenase / androstan-3-alpha,17-beta-diol dehydrogenase activity / dihydrotestosterone 17-beta-dehydrogenase activity / androsterone dehydrogenase activity / testosterone dehydrogenase (NAD+) activity / testosterone biosynthetic process / RA biosynthesis pathway / retinal metabolic process / regulation of retinoic acid receptor signaling pathway / ketosteroid monooxygenase activity / steroid dehydrogenase activity / Synthesis of bile acids and bile salts via 24-hydroxycholesterol / testosterone 17-beta-dehydrogenase (NADP+) activity / progesterone metabolic process / 17beta-estradiol 17-dehydrogenase / Synthesis of Prostaglandins (PG) and Thromboxanes (TX) / 17-beta-hydroxysteroid dehydrogenase (NAD+) activity / NAD-retinol dehydrogenase activity / aldo-keto reductase (NADP) activity / cyclooxygenase pathway / positive regulation of endothelial cell apoptotic process / prostaglandin H2 endoperoxidase reductase activity / NADP-retinol dehydrogenase activity / Oxidoreductases; Acting on the CH-OH group of donors; With NAD+ or NADP+ as acceptor / daunorubicin metabolic process / oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor / doxorubicin metabolic process / retinal dehydrogenase activity / bile acid binding / prostaglandin metabolic process / retinoid metabolic process / alditol:NADP+ 1-oxidoreductase activity / renal absorption / steroid metabolic process / Synthesis of bile acids and bile salts via 27-hydroxycholesterol / Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol / Retinoid metabolism and transport / keratinocyte differentiation / cellular response to calcium ion / cellular response to starvation / response to nutrient / positive regulation of cell death / cellular response to cadmium ion / cellular response to reactive oxygen species / male gonad development / positive regulation of reactive oxygen species metabolic process / positive regulation of protein kinase B signaling / G protein-coupled receptor signaling pathway / positive regulation of cell population proliferation / extracellular exosome / nucleus / cytosol / cytoplasm\nSimilarity search - Function\nAldo-keto reductase family 1 member C / Aldo/keto reductase family putative active site signature. / Aldo/keto reductase family signature 1. / Aldo/keto reductase family signature 2. / Aldo/keto reductase, conserved site / NADP-dependent oxidoreductase domain / Aldo-keto reductase / NADP-dependent oxidoreductase domain / Aldo/keto reductase family / NADP-dependent oxidoreductase domain superfamily ...Aldo-keto reductase family 1 member C / Aldo/keto reductase family putative active site signature. / Aldo/keto reductase family signature 1. / Aldo/keto reductase family signature 2. / Aldo/keto reductase, conserved site / NADP-dependent oxidoreductase domain / Aldo-keto reductase / NADP-dependent oxidoreductase domain / Aldo/keto reductase family / NADP-dependent oxidoreductase domain superfamily / TIM Barrel / Alpha-Beta Barrel / Alpha Beta\nSimilarity search - Domain/homology\nChem-15M / NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE / Aldo-keto reductase family 1 member C3\nSimilarity search - Component\n|Biological species||Homo sapiens (human)|\n|Method||X-RAY DIFFRACTION / MOLECULAR REPLACEMENT / Resolution: 2 Å|\n|Authors||Komoto, J. / Yamada, T. / Watanabe, K. / Woodward, D.F. / Takusagawa, F.|\n|Citation||Journal: Biochemistry / Year: 2006|\nTitle: Prostaglandin F2alpha formation from prostaglandin H2 by prostaglandin F synthase (PGFS): crystal structure of PGFS containing bimatoprost.\nAuthors: Komoto, J. / Yamada, T. / Watanabe, K. / Woodward, D.F. / Takusagawa, F.\n|Structure viewer||Molecule: |\nDownloads & links\nA: Aldo-keto reductase family 1 member C3\n|Details||Monomeric protein containing one NADPH and one bimatoprost.|\n|#1: Protein|| |\nMass: 36896.215 Da / Num. of mol.: 1\nSource method: isolated from a genetically manipulated source\nSource: (gene. exp.) Homo sapiens (human) / Gene: AKR1C3, DDH1, KIAA0119, PGFS / Plasmid: pUC-hLuFS / Production host: Escherichia coli (E. coli) / Strain (production host): HB101\nReferences: UniProt: P42330, trans-1,2-dihydrobenzene-1,2-diol dehydrogenase, EC: 126.96.36.199, prostaglandin-F synthase, 17beta-estradiol 17-dehydrogenase\n|#2: Chemical|| ChemComp-NAP / |\n|#3: Chemical|| ChemComp-15M / (|\n|#4: Water|| ChemComp-HOH / |\n|Experiment||Method: X-RAY DIFFRACTION / Number of used crystals: 1|\n|Crystal||Density Matthews: 2.26 Å3/Da / Density % sol: 45.46 %|\n|Crystal grow||Temperature: 277 K / Method: vapor diffusion, hanging drop / pH: 7 |\nDetails: 1.0 mM BMP, 1.0 mM NADPH, 0.14 M NaCl, 50 mM MES, 26% PEG-8000, pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 277K\n|Diffraction||Mean temperature: 95 K|\n|Diffraction source||Source: ROTATING ANODE / Type: RIGAKU RU200 / Wavelength: 1.5418 Å|\n|Detector||Type: RIGAKU RAXIS IIC / Detector: IMAGE PLATE / Date: May 5, 2005 / Details: confocal optics|\n|Radiation||Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray|\n|Radiation wavelength||Wavelength: 1.5418 Å / Relative weight: 1|\n|Reflection||Resolution: 2→20 Å / Num. all: 19525 / Num. obs: 19525 / % possible obs: 89 % / Observed criterion σ(F): 0 / Observed criterion σ(I): 0|\n|Reflection shell||Resolution: 2→2.1 Å / % possible all: 63|\n|Refinement||Method to determine structure: MOLECULAR REPLACEMENT|\nStarting model: pdb entry 1RY0\nResolution: 2→20 Å / σ(F): 0 / Stereochemistry target values: Engh & Huber\n|Refinement step||Cycle: LAST / Resolution: 2→20 Å|\n-Feb 9, 2022. New format data for meta-information of EMDB entries\nNew format data for meta-information of EMDB entries\n- Version 3 of the EMDB header file is now the official format.\n- The previous official version 1.9 will be removed from the archive.\nRelated info.:EMDB header\nExternal links:wwPDB to switch to version 3 of the EMDB data model\n-Aug 12, 2020. Covid-19 info\nNew page: Covid-19 featured information page in EM Navigator.\nRelated info.:Covid-19 info / Mar 5, 2020. Novel coronavirus structure data\n+Mar 5, 2020. Novel coronavirus structure data\nNovel coronavirus structure data\n- International Committee on Taxonomy of Viruses (ICTV) defined the short name of the 2019 coronavirus as \"SARS-CoV-2\".\n- The species Severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2 - nature microbiology\n- In the structure databanks used in Yorodumi, some data are registered as the other names, \"COVID-19 virus\" and \"2019-nCoV\". Here are the details of the virus and the list of structure data.\nRelated info.:Yorodumi Speices / Aug 12, 2020. Covid-19 info\n+Jan 31, 2019. EMDB accession codes are about to change! (news from PDBe EMDB page)\nEMDB accession codes are about to change! (news from PDBe EMDB page)\n- The allocation of 4 digits for EMDB accession codes will soon come to an end. Whilst these codes will remain in use, new EMDB accession codes will include an additional digit and will expand incrementally as the available range of codes is exhausted. The current 4-digit format prefixed with “EMD-” (i.e. EMD-XXXX) will advance to a 5-digit format (i.e. EMD-XXXXX), and so on. It is currently estimated that the 4-digit codes will be depleted around Spring 2019, at which point the 5-digit format will come into force.\n- The EM Navigator/Yorodumi systems omit the EMD- prefix.\nRelated info.:Q: What is EMD? / ID/Accession-code notation in Yorodumi/EM Navigator\n+Jul 12, 2017. Major update of PDB\nMajor update of PDB\n- wwPDB released updated PDB data conforming to the new PDBx/mmCIF dictionary.\n- This is a major update changing the version number from 4 to 5, and with Remediation, in which all the entries are updated.\n- In this update, many items about electron microscopy experimental information are reorganized (e.g. em_software).\n- Now, EM Navigator and Yorodumi are based on the updated data.\nThousand views of thousand structures\n- Yorodumi is a browser for structure data from EMDB, PDB, SASBDB, etc.\n- This page is also the successor to EM Navigator detail page, and also detail information page/front-end page for Omokage search.\n- The word \"yorodu\" (or yorozu) is an old Japanese word meaning \"ten thousand\". \"mi\" (miru) is to see.\nRelated info.:EMDB / PDB / SASBDB / Comparison of 3 databanks / Yorodumi Search / Aug 31, 2016. New EM Navigator & Yorodumi / Yorodumi Papers / Jmol/JSmol / Function and homology information / Changes in new EM Navigator and Yorodumi", "domain": "chemistry", "round": 3} +{"url": "https://www.tradetextile.com/archives/6434", "date": "2024-04-19T15:18:11Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712296817438.43/warc/CC-MAIN-20240419141145-20240419171145-00729.warc.gz", "language_score": 0.9365819096565247, "token_count": 528, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__19533694", "lang": "en", "text": "People’s production and life will produce a large amount of domestic garbage. If a large amount of garbage is not processed in time, it will occupy a large amount of land, affect the beauty of the environment, destroy the vegetation on the earth’s surface, and be harmful to us. The living environment is becoming very polluted. The manufacturer of Polytetrafluoroethylene dust removal film will show you how to deal with it.\nSolid waste contains various harmful substances. Improper treatment can directly pollute soil, air and water sources, and ultimately affect various living creatures, including humans. causing harm to oneself. Fine solid waste that pollutes soil and water will fly in the wind, aggravating air pollution. In areas where a large amount of garbage is piled in the open, the stench is high, rats are infested, mosquitoes and flies breed, and large amounts of ammonia, sulfide and other harmful gases are released into the atmosphere. There are more than 100 types of organic volatile gases alone, including many that are carcinogenic. Teratogens. Therefore, we need to pay great attention to the disposal of garbage. We cannot just throw it into nature and wait for nature to decompose it. This method is not advisable and will bring us more serious pollution. Polytetrafluoroethylene dust removal membrane plays a great role in garbage flue gas treatment.\nThere are many modes of garbage disposal, including sanitary landfill, biological treatment, incineration and power generation, etc. Incineration is a commonly used method. This method uses high-temperature oxidation to treat domestic waste – burning domestic waste at high temperatures to convert the combustible waste in the domestic waste into carbon dioxide and water. The ash and slag after incineration are It is only less than 20% of the original volume of domestic waste, which greatly reduces the amount of solid waste and can also eliminate various pathogens. However, this method also has some disadvantages. During incineration, a large amount of waste gas will be produced to pollute the air. If it is not treated, it will also have a great impact on air quality.\nTherefore, the flue gas from waste incineration will be filtered before being discharged. The use of dust filter bags can help waste incineration plants reliably control particulate matter emissions and pollution. Dust filter bags made of PTFE dust removal membrane can reliably capture particles to ensure zero emissions, have good dust stripping performance, extend service life and stability, thereby reducing costs. Interested parties can enter the store for consultation and purchase!", "domain": "chemistry", "round": 3} +{"url": "https://iris.unica.it/handle/11584/95923", "date": "2017-12-17T13:59:01Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-51/segments/1512948596051.82/warc/CC-MAIN-20171217132751-20171217154751-00274.warc.gz", "language_score": 0.8774917721748352, "token_count": 341, "dump": "CC-MAIN-2017-51", "global_id": "webtext-fineweb__CC-MAIN-2017-51__0__62433582", "lang": "en", "text": "Objective: Metabolomics is a new ‘‘omics’’ platform aimed at high-throughput identification, quantification and characterization of small molecule metabolites. The metabolomics approach has been successfully applied to the classification different physiological states and identification of perturbed biochemical pathways. The purpose of the current investigation is the application of metabolomics to explore biological mechanisms which may lead to the onset of metabolic syndrome in adulthood. Methods: We evaluated differences in metabolites in the urine collected within 12 hours from 23 infants with IUGR (IntraUterine Growth Restriction), or LGA (Large for Gestational Age), compared to control infants (10 patients defined AGA: Appropriate for Gestational Age). Urinary metabolites were quantified by GC-MS and used to highlight similarities between the two metabolic diseases and identify metabolic markers for their predisposition. Quantified metabolites were analyzed using a multivariate statistics coupled with receiver operator characteristic curve (ROC) analysis of identified biomarkers. Results: Urinary myo-inositol was the most important discriminant between LGA + IUGR and control infants, and displayed an area under the ROC curve¼1. Conclusion: We postulate that the increase in plasma and consequently urinary inositol may constitute a marker of altered glucose metabolism during fetal development in both IUGR and LGA newborns.\n|Titolo:||Urinary metabolomics (GC-MS) reveals that low and high birth weight infants share elevated inositol concentrations at birth|\n|Data di pubblicazione:||2014|\n|Tipologia:||1.1 Articolo in rivista|", "domain": "chemistry", "round": 3} +{"url": "https://www.watsons.com.sg/hair-growth-trigger-180ml/p/BP_58531", "date": "2023-02-05T17:22:43Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-06/segments/1674764500273.30/warc/CC-MAIN-20230205161658-20230205191658-00473.warc.gz", "language_score": 0.8619276881217957, "token_count": 360, "dump": "CC-MAIN-2023-06", "global_id": "webtext-fineweb__CC-MAIN-2023-06__0__109473888", "lang": "en", "text": "Also, activates nutrition supply to hair root from vessels, and promote the production of new hair by activating hair papilla.\nMoreover, the hair cycle of downy hair will be normalized, and make your hair thick and strong.\nIt is effective for circular loss of hair as well.\nPlace of Origin\nSprinkle a generous amount of KAMINOMOTO HAIR GROWTH TRIGGER onto the scalp twice a day. Massage gently with fingertips to work in the solution. Treatment should be applied more generously before bedtime to work with scalp's natural nourishing properties while you sleep. Applying an appropriate amount regularly over a long time is more effective than applying a large amount at once.\nISODON TRICHOCARPUS EXTRACT, SODIUM SUCCINATE, PANTHENOL, ALLANTOIN, SALICYLIC ACID, PYRIDOXINE HCL, GLYCYRRHETINIC ACID, POTTASSIUM HYDROXIDE, PEG-40 HYDROGENATED CASTOR OIL, EUONYMUS JAPONICUS LEAF EXTRACT, ALCOHOL DENAT., WATER, FRAGRANCE\nIn case of adverse reactions after use, you're advised to stop using it immediately. In case of getting it into your eyes, you have to wash it immediately.", "domain": "chemistry", "round": 3} +{"url": "https://www.mdpi.com/journal/metabolites/special_issues/biotechnology", "date": "2021-04-10T21:42:38Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-17/segments/1618038059348.9/warc/CC-MAIN-20210410210053-20210411000053-00190.warc.gz", "language_score": 0.9034730792045593, "token_count": 636, "dump": "CC-MAIN-2021-17", "global_id": "webtext-fineweb__CC-MAIN-2021-17__0__262563541", "lang": "en", "text": "Special Issue \"Metabolomics-Driven Biotechnology\"\nDeadline for manuscript submissions: closed (31 October 2019).\nInterests: Flux Balance Analysis; Dynamic Modeling; Bioprocess Development\nBio-productions of useful compounds including foods, fermentation beverages, pharmaceuticals, chemicals, and fuels have been performed around the world. Metabolism is a sequence of chemical reactions in cells, and is the most important phenotype directly related to cellular activities. Redox and co-factor balance in the metabolism is also important to effectively increase the metabolic flow to target compounds. Marker metabolites are very useful to diagnose diseases in many medial applications. Precise and accurate analyses of metabolites and the development of control methods for the metabolism are key issues in biotechnology.\nRecent big advances in comprehensive and specific analysis technology—including mass spectrometry and NMR—and in information technology with big metabolomics data are providing a new concept for “metabolomics-driven biotechnology”. This Special Issue of Metabolites is dedicated not only to the new analytical techniques, but also to the metabolic engineering strategies driven by metabolomics data. The topics of the Special Issue include cutting edge experimental and computational researches in the related area: target and non-target metabolome analyses, isotope labeling techniques, metabolic flux analysis, identification techniques for important genes to confer the superior phenotypes of cells, genome-wide and local metabolic modeling with static and dynamic metabolism data, and applications of metabolome analysis to the development of bio-production processes and medical treatments.\nProf. Hiroshi Shimizu\nDr. Yoshihiro Toya\nManuscript Submission Information\nManuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.\nSubmitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.\nPlease visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.\n- 13C Metabolic Flux Analysis\n- Flux Balance Analysis\n- Kinetic Modelling\n- Flux Analysis in Mammalian Cells", "domain": "chemistry", "round": 3} +{"url": "http://research.chem.ox.ac.uk/emily-flashman.aspx", "date": "2016-06-26T11:42:18Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2016-26/segments/1466783395166.84/warc/CC-MAIN-20160624154955-00060-ip-10-164-35-72.ec2.internal.warc.gz", "language_score": 0.6541734933853149, "token_count": 593, "dump": "CC-MAIN-2016-26", "global_id": "webtext-fineweb__CC-MAIN-2016-26__0__41655741", "lang": "en", "text": "Tarhonskaya H, Hardy AP, Howe EA, Loik ND, Kramer HB, McCullagh JS, Schofield CJ, Flashman E (2015). Kinetic investigations of the role of factor inhibiting hypoxia-inducible factor (FIH) as an oxygen sensor. J Biol Chem. 290: 19726-19742.\nHancock RL, Dunne K, Walport LJ, Flashman E, Kawamura A (2015). Epigenetic regulation by histone demethylases in hypoxia. Epigenomics. 7: 791-811.\nTarhonskaya H, Chowdhury R, Leung IK, Loik ND, McCullagh JS, Claridge TD, Schofield CJ and Flashman E (2014). Investigating the contribution of the active site environment to the slow reaction of hypoxia-inducible factor prolyl hydroxylase domain 2 with oxygen. Biochem J. 463: 363-372.\nTarhonskaya H, Szöllössi A, Leung IK, Bush JT, Henry L, Chowdhury R, Iqbal A, Claridge TD, Schofield CJ and Flashman E (2014). Studies on deacetoxycephalosporin C synthase support a consensus mechanism for 2-oxoglutarate dependent oxygenases. Biochemistry. 53: 2483-2493.\nTarhonskaya H, Rydzik AM, Leung IK, Loik ND, Chan MC, Kawamura A, McCullagh JS, Claridge TD, Flashman E and Schofield CJ (2014). Non-enzymatic chemistry enables 2-hydroxyglutarate-mediated activation of 2-oxoglutarate oxygenases. Nat Commun. 5: 3423.\nSanchez-Fernandez EM, Tarhonskaya H, Al-Qahtani K, Hopkinson RJ, McCullagh JS, Schofield CJ, Flashman E (2013). Investigations on the oxygen dependence of a 2-oxoglutarate histone demethylase. Biochem J. 449: 491-496.\nFlashman E, Hoffart LM, Hamed RB, Bollinger Jr JM, Krebs C, Schofield CJ (2010). Evidence for the slow reaction of hypoxia-inducible factor prolyl hydroxylase 2 with oxygen. FEBS J. 277: 4089-4099\nFlashman E, Davies SL, Yeoh KK, Schofield CJ (2010). Investigating the dependence of the hypoxia-inducible factor hydroxylases (factor inhibiting HIF and prolyl hydroxylase domain 2) on ascorbate and other reducing agents. Biochem J. 427: 135-142.", "domain": "chemistry", "round": 3} +{"url": "https://www.thestationerycompany.pk/collections/watercolor-medium", "date": "2021-03-03T02:38:42Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-10/segments/1614178365186.46/warc/CC-MAIN-20210303012222-20210303042222-00507.warc.gz", "language_score": 0.858703076839447, "token_count": 283, "dump": "CC-MAIN-2021-10", "global_id": "webtext-fineweb__CC-MAIN-2021-10__0__125429203", "lang": "en", "text": "Daler Rowney Aquafine Watercolour MediumsAdd to Wish List\nDaler-Rowney Aquafine Watercolour Mediums are used to change the rate of drying, increase gloss, improve flow or provide texture. They provide watercolourists with limitless opportunities to add special effects and add variations to their watercolour paintings. Products: Poster & Watercolor Varnish 75ml...\nWinsor Newton Watercolor Auxiliaries Gum Arabic 75mlAdd to Wish List\nGum Arabic is a pale-colored solution that controls the spread of wet color Reduces staining and slows drying Increase transparency, brilliance, and gloss Dilute with water as required Comes in a 75-ml bottle\nWinsor Newton Watercolors Art Masking Fluid Colourless 75mlAdd to Wish List\nArt masking fluid is a colorless, non-staining liquid composed of rubber latex For masking areas of work needing protection when color is applied in broad washes Do not use on damp or soft sized paper Remove as soon as possible...\nWinsor Newton Watercolors Art Masking Fluid 75mlAdd to Wish List\nArt masking fluid is a pigmented liquid composed of rubber latex and pigment For masking areas of work needing protection when color is applied in broad washes Conforms to Astm d4236 Comes in 75-mL bottle Available in yellow color", "domain": "chemistry", "round": 3} +{"url": "http://ir.acimmune.com/phoenix.zhtml?c=254264&p=irol-SECText&TEXT=aHR0cDovL2FwaS50ZW5rd2l6YXJkLmNvbS9maWxpbmcueG1sP2lwYWdlPTEyNzkyMjYxJkRTRVE9MSZTRVE9NTQmU1FERVNDPVNFQ1RJT05fUEFHRSZleHA9JnN1YnNpZD01Nw%3D%3D", "date": "2019-05-20T18:31:06Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-22/segments/1558232256100.64/warc/CC-MAIN-20190520182057-20190520204057-00223.warc.gz", "language_score": 0.8891361355781555, "token_count": 543, "dump": "CC-MAIN-2019-22", "global_id": "webtext-fineweb__CC-MAIN-2019-22__0__39160103", "lang": "en", "text": "Our Proprietary Technology Platforms\nOur two unique proprietary and versatile\ntechnology platforms are engines to drive the growth of our development: our SupraAntigen platform, which is our biological and\nimmunological platform, and our Morphomer platform, which is our small molecule, chemical platform. These platforms are designed\nto generate vaccines, antibodies and small molecules, respectively, which selectively interact with misfolded proteins that are\ncommon in a broad range of neurodegenerative diseases.\nOur SupraAntigen platform generates humanized\nmonoclonal antibodies and vaccines for use as passive and active immunotherapies that are highly specific for pathological, or\nmisfolded, forms of proteins typically found in neurodegenerative diseases.\nThe key advantages of the SupraAntigen\n|·||Highly selective conformation-specific immunotherapy;|\n|·||Generation of antibodies and vaccines;|\n|·||Generation of a rapid antibody response; and|\n|·||Favorable safety avoiding T-cell mediated inflammation.|\nProduct candidates generated utilizing\nthe SupraAntigen platform include crenezumab in Phase 2 in AD, ACI-24 in Phase 2 in AD and Phase 1b in DS, ACI-35 in Phase 1b in\nAD, an anti-Tau antibody in Phase 2 in AD and the pre-clinical antibodies for alpha-synuclein/TDP-43 in PD and neuro-orphan indications.\nOur Morphomer platform represents a highly\npromising technology that enables us to generate conformation specific small molecules through rational design. As of December 31,\n2018, our Morphomer library consisted of more than 4,750 compounds. This proprietary platform enables us to generate small molecules\nthat bind to their target and break up neurotoxic protein aggregates or act as propagation inhibitors.\nTherapeutic product candidates generated\nby the Morphomer platform include the pre-clinical therapeutic programs such as Morphomer Tau in AD, Morphomer alpha-synuclein\nin PD and the diagnostic programs Tau-PET imaging agent in Phase 1 in AD and PSP and alpha-synuclein-PET and TDP-43 PET imaging\nagents in the pre-clinical stage.\nOur AD Programs\nCrenezumab is a humanized, conformation-specific\nmonoclonal antibody that targets misfolded Abeta and has a broad binding profile. Crenezumab was developed using our proprietary\nSupraAntigen platform. In 2006, we licensed crenezumab to Genentech, a company with a long history of developing and commercializing", "domain": "chemistry", "round": 3} +{"url": "http://wikien3.appspot.com/wiki/Dinalbuphine_sebacate", "date": "2019-10-16T05:50:34Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-43/segments/1570986664662.15/warc/CC-MAIN-20191016041344-20191016064844-00365.warc.gz", "language_score": 0.6520518064498901, "token_count": 1290, "dump": "CC-MAIN-2019-43", "global_id": "webtext-fineweb__CC-MAIN-2019-43__0__635629", "lang": "en", "text": "|Synonyms||DNS; Nalbuphine sebacate; Sebacoyldinalbuphine; SDN; Sebacoyl dinalbuphine ester; SDE; LT-1001|\n|Drug class||Opioid analgesic|\n|Bioavailability||• IM: 85.4% (relative to nalbuphine)|\n|Elimination half-life||• DNS: 83.2 hours (mean absorption time: 145.2 hours)|\n• Nalbuphine: 4.0 hours\n|Chemical and physical data|\n|Molar mass||881.12 g/mol g·mol−1|\n|3D model (JSmol)|\nDinalbuphine sebacate (DNS), also known as nalbuphine sebacate or as sebacoyl dinalbuphine ester (SDE) and sold under the brand name Naldebain, is a non-controlled opioid analgesic which is used as a 7-day long-acting injection in the treatment of moderate to severe postoperative pain. It was developed by Lumosa Therapeutics and was approved in Taiwan in the spring of 2017; development is ongoing in the United States. The compound is a diester of nalbuphine (Nubain) joined via a sebacic acid linker, and acts as a long-lasting prodrug of nalbuphine via slow hydrolysis. It was developed to extend the duration of action of nalbuphine, which has a short duration and requires frequent injections. Whereas nalbuphine must be injected every 4 to 6 hours, a single injection of DNS lasts for up to 7 to 10 days. Nalbuphine, and hence DNS, acts as a mixed agonist/antagonist opioid modulator, or more specifically as a moderate-efficacy partial agonist or antagonist of the μ-opioid receptor and as a high-efficacy partial agonist of the κ-opioid receptor.\n- Pao LH, Hsiong CH, Hu OY, Wang JJ, Ho ST (March 2005). \"In vitro and in vivo evaluation of the metabolism and pharmacokinetics of sebacoyl dinalbuphine\". Drug Metab. Dispos. 33 (3): 395–402. doi:10.1124/dmd.104.002451. PMID 15608131.\n- Tien YE, Huang WC, Kuo HY, Tai L, Uang YS, Chern WH, Huang JD (November 2017). \"Pharmacokinetics of dinalbuphine sebacate and nalbuphine in human after intramuscular injection of dinalbuphine sebacate in an extended-release formulation\". Biopharm Drug Dispos. 38 (8): 494–497. doi:10.1002/bdd.2088. PMID 28741675.\n- \"Dinalbuphine sebacate - Lumosa Therapeutics - AdisInsight\". adisinsight.springer.com.\n- \"Lumosa Therapeutics Partners with Camargo Pharmaceutical Services in the Development of Naldebain(R) in the US\". www.prnewswire.com.\n- Yeh CY, Jao SW, Chen JS, Fan CW, Chen HH, Hsieh PS, Wu CC, Lee CC, Kuo YH, Hsieh MC, Huang WS, Chung YC, Liou TY, Chiu HH, Tseng WK, Lee KC, Wang JY (May 2017). \"Sebacoyl Dinalbuphine Ester Extended-release Injection for Long-acting Analgesia: A Multicenter, Randomized, Double-Blind, And Placebo-controlled Study in Hemorrhoidectomy Patients\". Clin J Pain. 33 (5): 429–434. doi:10.1097/AJP.0000000000000417. PMID 27518486.\n- Pao LH, Hsiong CH, Hu OY, Ho ST (September 2000). \"High-performance liquid chromatographic method for the simultaneous determination of nalbuphine and its prodrug, sebacoyl dinalbuphine ester, in dog plasma and application to pharmacokinetic studies in dogs\". J. Chromatogr. B. 746 (2): 241–7. doi:10.1016/S0378-4347(00)00326-1. PMID 11076077.\n- Narver HL (March 2015). \"Nalbuphine, a non-controlled opioid analgesic, and its potential use in research mice\". Lab Anim (NY). 44 (3): 106–10. doi:10.1038/laban.701. PMID 25693108.\n- Schmidt WK, Tam SW, Shotzberger GS, Smith DH, Clark R, Vernier VG (February 1985). \"Nalbuphine\". Drug Alcohol Depend. 14 (3–4): 339–62. doi:10.1016/0376-8716(85)90066-3. PMID 2986929.\n- Paul G. Barash (2009). Clinical Anesthesia. Lippincott Williams & Wilkins. pp. 489–. ISBN 978-0-7817-8763-5.\n- Peng X, Knapp BI, Bidlack JM, Neumeyer JL (May 2007). \"Pharmacological properties of bivalent ligands containing butorphan linked to nalbuphine, naltrexone, and naloxone at mu, delta, and kappa opioid receptors\". J. Med. Chem. 50 (9): 2254–8. doi:10.1021/jm061327z. PMC 3357624. PMID 17407276.\n|This analgesic-related article is a stub. You can help Wikipedia by expanding it.|", "domain": "chemistry", "round": 3} +{"url": "http://www.bio.umass.edu/mcb/faculty/Park.html", "date": "2020-10-23T08:49:51Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-45/segments/1603107880878.30/warc/CC-MAIN-20201023073305-20201023103305-00405.warc.gz", "language_score": 0.845626175403595, "token_count": 1626, "dump": "CC-MAIN-2020-45", "global_id": "webtext-fineweb__CC-MAIN-2020-45__0__50079960", "lang": "en", "text": "Assistant Professor of Food Science, University of Massachusetts\nPh.D.: University of Wisconsin-Madison 1996\nMy current research interests can be divided into two categories; first, continuation of conjugated linoleic acid (CLA) research and secondly, searches for biologically active compounds from natural or dietary sources.\nA. Conjugated Linoleic Acid (CLA) Research\nCLA was originally identified unexpectedly as an anti-cancer principal from ground beef in 1987. Since then, CLA has shown other biologically beneficial activities, including reducing severity of atherosclerosis, reducing the adverse effects of immune stimulation, enhancing feed efficiency, and most interestingly reducing body fat accumulation while enhancing lean body mass. As a relatively simple compound, it was quite unexpected for it to have such a variety of activities. The natural question is how CLA can achieve all of these activities.\nCLA has potential use as a pharmaceutical, for example, as an anti-cancer drug, as a supplement to cancer patients to combat cachexia caused by chemotherapy, or as a supplement in diabetes to increase insulin sensitivity. Moreover, with its recent availability to the public as a nutritional supplement, it is important to investigate the exact mechanism of CLA, especially in humans. Based on my knowledge and experience with CLA, I would like to explore unanswered questions of CLA research.\nB. Biologically Active Compounds from Natural or Dietary Sources\nIt is generally recommended to consume more fruit, vegetables, and nuts to reduce the incidence and severity of cardiovascular disease. Antioxidants in vegetables are believed to play an important role, but the exact mechanism as well as the active components are still unknown. My research will use tissue cell cultures as well as animal models to test vegetables, fruits, and nuts. This can be followed by identification of mechanisms and may lead to useful information in other areas.\nY. Park, Y. L. Ha, and M. W. Pariza (2005) p-Complex formation of conjugated linoleic acid (CLA) with iron, Food Chem. (submitted).\nS.-H. Lee, K. Yamaguchi, J.-S. Kim, T. E. Eling, Y. Park , and S. J. Baek (2005) Conjugated linoleic acid stimulates an anti-tumorigenic protein NAG-1 in an isomer specific manner, Carcinogenesis (submitted).\nS. Mun, E. A. Decker, Y. Park , J. Weiss, and D. J. McClements (2005) Influence of interfacial composition on in vitro digestibility of emulsified lipids: Potential mechanisms for chitosan's ability to inhibit fat absorption, Food Biophysics (submitted).\nY. Park , K. J. Albright, and M. W. Pariza (2005) Effects of Conjugated Linoleic Acid on Long Term Feeding in Fischer 344 Rats, Food Chem. Tox. 43: 1273-1279.\nJ. M. Storkson, Y. Park , M. E. Cook, and M. W. Pariza (2005), Effects of trans-10,cis-12 Conjugated Linoleic Acid (CLA) on Cognates on Apolipoprotein B Secretion in HepG2 Cells, Nutr. Res. 25 : 387-399.\nY. Park, J. M. Storkson, W. Liu, K. J. Albright, M. E. Cook, and M. W. Pariza (2004) Structure-Activity Relationship of Conjugated Linoleic Acid and its Cognates in Inhibition of Heparin-releasable Lipoprotein Lipase and Glycerol Release from Fully Differentiated 3T3-L1 Adipocytes, J. Nutr. Biochem.15: 561-569.\nY. Park, H. Yang, J. M. Storkson, K. J. Albright, W. Liu, R. C. Lindsay and M. W. Pariza (2004) Controlling acrylamide in French fry and potato chip models and a mathematical model of acrylamide formation, Adv. Exp. Med. Biol. (in press).\nJ. M. Storkson, Y. Park, M. E. Cook, and M. W. Pariza (2004), Effects of trans-10,cis-12 Conjugated Linoleic Acid (CLA) on Cognates on Apolipoprotein B Secretion in HepG2 Cells, Nutr. Res. (in press).\nS.-H. Lee, K. Yamaguchi, J.-S. Kim, T. E. Eling, Y. Park, M. W. Pariza, and S. J. Baek (2004) Conjugated linoleic acid stimulates anti-tumorigenic protein NAG-1 by isomer specific manner, Carcinogenesis (submitted).\nY. Park, J. M. Storkson, K. J. Albright, W. Liu, and M. W. Pariza (2004) Biological Activities of Conjugated Fatty Acids: Conjugated Eicosadienoic (conj. 20:2Δc11,t13/ t12,c14), Eicosatrienoic (conj. 0:3Δc8,t12,c14),and Heneicosadienoic (conj. 21:2Δc12,t14/ c13,t15) Acids and Other Metabolites of Conjugated Linoleic Acid, Biochim. Biophys. Acta (submitted).\nX. Xu, J. Storkson, S. Kim, K. Sugimoto, Y. Park, and M. W. Pariza (2003), Early Effects of Dietary Conjugated Linoleic Acid on Mouse Adipose Tissue Include Inhibiting Lipoprotein Lipase and Glucose Metabolism but Not Enhancing Lipolysis, J. Nutr.133: 663-667.\nK. Kang, W. Liu, K. J. Albright, Y. Park, and M. W. Pariza (2003), Trans-10, cis-12 CLA Inhibits Differentiation of 3T3-L1 Adipocytes and Decreases PPARγ Expression, Biochem. Biophy. Res. Comm.303: 795-799.\nL. D. Whigham, D. E. Bjorling, A. Higbee, Y. Park, M. W. Pariza, and M. E. Cook (2002), Decreased Antigen-induced Eicosanoid Release in Conjugated Linoleic Acid (CLA)-fed Guinea Pigs, Am. J. Physiol.284(4): R1104-R1112.\nY. Choi, Y. Park, J. M. Storkson, M. W. Pariza, and J. M. Ntambi (2002), Inhibition of Stearoyl-CoA Desaturase Activity by the Cis-9,trans-11 Isomer and the Trans-10,cis-12 Isomer of Conjugated Linoleic Acid in MDA-MB-231 and MCF-7 Human Breast Cancer Cells, Biochem. Biophy. Res. Comm.294 (4): 785-790.\nM. R. Kim, Y. Park, K. J. Albright, and M. W. Pariza (2002), Differential Responses of Hamsters and Rats Fed High-fat or Low-fat Diets Supplemented with Conjugated Linoleic Acid, Nutr. Res. 22: 715-722.", "domain": "chemistry", "round": 3} +{"url": "https://books.google.com/books/about/Chloride_Movements_Across_Cellular_Membr.html?id=0cHDODVP-YIC&hl=en", "date": "2018-01-20T01:35:17Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-05/segments/1516084888341.28/warc/CC-MAIN-20180120004001-20180120024001-00432.warc.gz", "language_score": 0.7882916331291199, "token_count": 573, "dump": "CC-MAIN-2018-05", "global_id": "webtext-fineweb__CC-MAIN-2018-05__0__237193183", "lang": "en", "text": "Chloride Movements Across Cellular Membranes\nElsevier, Sep 22, 2011 - Science - 392 pages\nAll living cells are surrounded by a lipidic membrane that isolates them from the often harsh environment. However, to take up nutrients, to excrete waste, and to communicate among each other, Nature has invented an incredibly diverse set of transmembrane transport proteins. Specialized transporters exist to shuttle electrically charged ions, positive cations like sodium or negative anions like chloride, across the membrane. In the recent years, tremendous progress has been made in the field of chloride transport. The present book presents the state of the art of this rapidly expanding and interest-gaining field of membrane transport. It is addressed at a broad medically, physiologically, biologically, and biophysically interested readership.\nWhat people are saying - Write a review\nWe haven't found any reviews in the usual places.\nStructure and Function of CLC Chloride Channels and Transporters\nPharmacology of CLC Chloride Channels and Transporters\nThe Physiology and Pharmacology of the CFTR Cl Channel\nGating of Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channel\nFunctional Properties of Ca2+Dependent Cl Channels and Bestrophins Do They Correlate?\nOther editions - View all\nABC transporter Acad Accardi acidification Alper amino acids anion exchanger apical ATP binding ATP hydrolysis Bartter syndrome basolateral bestrophins Biol blockers C‐terminal Ca2þ Ca2þ‐activated CaCCs cell volume CFTR CFTR channel CFTR ClÀ channel channel gating Chem chloride channel ClÀ/HCO3À exchange CLC proteins ClC‐ec1 cloning cotransporter cystic fibrosis cystic fibrosis transmembrane dimer endosomal epithelial cells expression fibrosis transmembrane conductance function GABA GABAA receptors GABAergic gene Genet Guggino Hartzell HCO3À human ICl,swell inhibition inhibitors interaction intercalated cells intracellular ion channels isoforms Jentsch KCC2 KCC3 KCC4 kidney Kþ channel Kþ‐ClÀ cotransport mammalian mechanism mediated mice modulation molecular mouse mutations Natl Naþ NBD1 NBD2 NBDs neurons Neurosci NKCC1 NKCC2 oocytes osteopetrosis pathway PDZ domain phosphorylation Physiol physiological plasma membrane pore postsynaptic potential protein kinase proximal tubule Pusch receptors renal residues role secretion skeletal muscle structure subunit synaptic tissues transmembrane conductance regulator tubule vesicles voltage Wang Xenopus oocytes", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/acadmmcad-antibody-c-terminal-ab228769.html", "date": "2020-10-22T09:58:03Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-45/segments/1603107879362.3/warc/CC-MAIN-20201022082653-20201022112653-00231.warc.gz", "language_score": 0.7156969904899597, "token_count": 819, "dump": "CC-MAIN-2020-45", "global_id": "webtext-fineweb__CC-MAIN-2020-45__0__146862301", "lang": "en", "text": "Key features and details\n- Rabbit polyclonal to ACADM/MCAD - C-terminal\n- Suitable for: WB, IHC-P, ICC/IF\n- Reacts with: Human\n- Isotype: IgG\nProduct nameAnti-ACADM/MCAD antibody - C-terminal\nSee all ACADM/MCAD primary antibodies\nDescriptionRabbit polyclonal to ACADM/MCAD - C-terminal\nTested applicationsSuitable for: WB, IHC-P, ICC/IFmore details\nSpecies reactivityReacts with: Human\nPredicted to work with: Chimpanzee\nSynthetic peptide within Human ACADM/MCAD (C terminal). The exact sequence is proprietary. (Carrier-protein conjugated).\nDatabase link: P11310\n- WB: HeLa S3 whole cell lysate. IHC-P: Human ovarian cancer tissue. ICC/IF: SK-N-SH cells.\nPreviously labelled as ACADM.\nStorage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.\nStorage bufferpH: 7.00\nPreservative: 0.01% Thimerosal (merthiolate)\nConstituents: 79.99% PBS, 20% Glycerol (glycerin, glycerine)\nConcentration information loading...\nPurityImmunogen affinity purified\n- Pathways and Processes\n- Metabolic signaling pathways\n- Lipid and lipoprotein metabolism\n- Lipid metabolism\nOur Abpromise guarantee covers the use of ab228769 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\n|WB||1/500 - 1/3000. Predicted molecular weight: 47 kDa.|\n|IHC-P||1/100 - 1/1000.|\n|ICC/IF||1/100 - 1/1000.|\nFunctionThis enzyme is specific for acyl chain lengths of 4 to 16.\nPathwayLipid metabolism; mitochondrial fatty acid beta-oxidation.\nInvolvement in diseaseDefects in ACADM are the cause of acyl-CoA dehydrogenase medium-chain deficiency (ACADMD) [MIM:201450]. It is an autosomal recessive disease which causes fasting hypoglycemia, hepatic dysfunction, and encephalopathy, often resulting in death in infancy.\nSequence similaritiesBelongs to the acyl-CoA dehydrogenase family.\nCellular localizationMitochondrion matrix.\n- Information by UniProt\n- ACAD 1 antibody\n- ACAD1 antibody\n- Acadm antibody\nAnti-ACADM/MCAD antibody - C-terminal (ab228769) at 1/1000 dilution + HeLa S3 whole cell lysate at 30 µg\nPredicted band size: 47 kDa\n10% SDS-PAGE gel.\n2% paraformaldehyde-fixed SK-N-SH (human neuroblastoma cell line) cells stained for ACADM/MCAD (green) using ab228769 at 1/500 dilution in ICC/IF.\nBlue: Hoechst 33342 staining.\nParaffin-embedded human ovarian cancer stained for ACADM/MCAD using ab228769 at 1/100 dilution in immunohistochemical analysis.\nTo our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.\nab228769 has not yet been referenced specifically in any publications.", "domain": "chemistry", "round": 3} +{"url": "http://www.promega.com/products/pm/genetic-identity/powerplex-y23", "date": "2015-03-31T09:56:35Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2015-14/segments/1427131300464.72/warc/CC-MAIN-20150323172140-00208-ip-10-168-14-71.ec2.internal.warc.gz", "language_score": 0.8868696093559265, "token_count": 811, "dump": "CC-MAIN-2015-14", "global_id": "webtext-fineweb__CC-MAIN-2015-14__0__17292785", "lang": "en", "text": "The PowerPlex® Y23 System allows Y-STR analysis of human forensic samples and database samples. The 5-dye STR multiplex includes the loci from the PowerPlex® Y System, Applied Biosystems' AmpFlSTR® Y-Filer® Kit, as well as six new, highly informative Y-STR loci.\nThe system enables laboratories to:\n- Reveal more Y-STR loci in excess female DNA\n- Cut your amplification time roughly in half\n- Simplify workflows with one kit for both casework and database samples\n- Obtain a full profile from precious samples, even those that are highly inhibited\nAmplify 23 Y-STR Loci in a Single PCR Reaction\nWith the ability to amplify 23 Y-STR loci, the PowerPlex® Y23 System enables the detection of more loci, resulting in fewer inconclusive results, and making the PowerPlex® Y23 System ideal for:\n- Forensic casework\n- Kinship analysis\n- Familial searching\nFigure 1. The PowerPlex® Y23 System allows co-amplification and four-color detection of 23 male-specific STR loci: DYS576, DYS389 I/II, DYS448, DYS19, DYS391, DYS481, DYS549, DYS533, DYS438 (penta), DYS437, DYS570, DYS635, DYS390, DYS439, DYS392, DYS643 (penta), DYS393, DYS458, DYS 385 a/b, DYS456 and YGATA-H4.\nAmplify Only Male DNA\nThe PowerPlex® Y23 System can successfully amplify trace amounts of male DNA, particularly in the presence of overabundant amounts of female DNA (6450-fold excess).\nFigure 2. This data indicates the percentage of loci called for samples with decreasing amounts of male DNA in the presence of 400ng of female DNA for three Y-STR kits; PowerPlex®Y23, AmpFlstr® Y-Filer®, and PowerPlex®Y. Amplified products were separated on an Applied Biosystems 3130xl Genetic Analyzer (3kV, 5-second injection).\nObtain Full Profiles from the Most Challenging Samples\nThe PowerPlex® Y23 System is a robust multiplex that that is tolerant of many amplification inhibitors including hematin, tannic acid, and humic acid. The robust performance of the kit results in more interpretable data and less need for re-amplification of inhibitor laden samples.\nFigure 3. Human genomic DNA (500pg; n = 3) was amplified with the PowerPlex® Y23 System in the presence of common inhibitors such as hematin, humic acid and tannic acid. Percent of loci called are indicated.\nStreamline Workflows with Direct Amplification\nThe PowerPlex® Y23 System is also compatible with direct amplification, helping to streamline Y-STR databasing efforts. Amplification can be successfully performed with sample types such as FTA® card punches as well as pretreated swabs, Bode Buccal DNA Collector™ punches or S&S 903 punches.\nFigure 4. Amplification of two 1.2mm punches from buccal on an FTA® card (direct amplification) using 27 cycles with the PowerPlex® Y23 System. Amplified products were separated on an Applied Biosystems 3130xl Genetic Analyzer (3kV, 5-second injection).\nFigure 5. Amplification of DNA on cotton swab pre-processed with SwabSolution™ prototype reagent using 26 cycles with the PowerPlex® Y23 System. Amplified products were separated on an Applied Biosystems 3130xl Genetic Analyzer (3kV, 5-second injection).", "domain": "chemistry", "round": 3} +{"url": "http://boatmanuals.tpub.com/TM-55-1915-200-SDC/TM-55-1915-200-SDC0122.htm", "date": "2019-11-15T16:35:21Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-47/segments/1573496668682.16/warc/CC-MAIN-20191115144109-20191115172109-00018.warc.gz", "language_score": 0.8929557204246521, "token_count": 278, "dump": "CC-MAIN-2019-47", "global_id": "webtext-fineweb__CC-MAIN-2019-47__0__123275813", "lang": "en", "text": "c. Immediately relieve and treat anyone evidencing sensitization.\nd. Wash all equipment with hot water and soap.\ne. Change clothes and shower after completion or work.\nf. Scrub down with a good natural skin detergent before securing and leaving the area. Wash hands frequently.\ng. Keep fingernails trimmed short and clean.\nh. Do not expose yourself to or breathe the noxious fumes given off during cure.\ni. Avoid spilling plastic materials. Keep kraft paper in areas where material is likely to spill or drip.\nj. Keep resin and hardener off skin areas whenever possible and use protective ointment. If contaminated, remove\nmaterial as feasible, using hot water and soap.\nk. Keep resin and hardener out of eyes; if contaminated, immediately rinse with water and obtain medical\nl. Remember always that a continuous high state of personal cleanliness is your most important and effective\nprotection. Wear gloves and goggles provided in this kit.\nm. Resin and hardeners are available on most ships which are incompatible with those provided in these kits. Do\nnot mix resin or hardener from any other source with those supplied in the repair kit. There is a probability that a violent\nreaction will occur if resins and hardeners are interchanged.\n8-31 (8-32 blank)", "domain": "chemistry", "round": 3} +{"url": "http://journal.waocp.org/article_27140.html", "date": "2023-02-04T16:23:46Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-06/segments/1674764500140.36/warc/CC-MAIN-20230204142302-20230204172302-00809.warc.gz", "language_score": 0.9022733569145203, "token_count": 369, "dump": "CC-MAIN-2023-06", "global_id": "webtext-fineweb__CC-MAIN-2023-06__0__115717200", "lang": "en", "text": "Cholangiocarcinoma (CCA) is the most common cancer in endemic areas of liver fluke infection. Althoughthe liver fluke is recognized as a carcinogenic agent in cholangiocarcinogenesis, other factors may play importantroles in bringing about the high prevalence of the cancer in populations of this region. Drug metabolizingenzymes (DME) are essential for detoxification of toxic and carcinogenic chemicals. Moreover, DME can play analternative role by activating chemicals to more toxic metabolites. The large variation of DME activity amongindividuals is partly due to polymorphism of the genes encoding enzymes. Defective or variant alleles of DMEgenes may modify the risk of cancer in those who are exposeed to carcinogenic agents. The focus in this reviewis on DME genes which have been reported to be associated with CCA risk. These include CYP1A2, arylamine-N-acetyltransferase-1 (NAT1) and NAT2, NADPH-quinone oxidorecutase-1 (NQO1), glutathione-S-transferaseM1 (GSTM1), GSTT1, GSTO1 and methylenetetrahydrofolate reductase (MTHFR). Mutant alleles which havebeen reportedly associated with an increased risk include CYP1A2*1F, GSTT1 null, GSTO1 and MTHFR 677C>T,whereas, slow NAT2 and NQO1*2 decrease risk and NAT1 variants and GSTM1 null have no effect. These genesmodify the risk of cancer potentially by interaction and exposure with certain environmental conditions, therebyaltering the metabolism of causative agents.", "domain": "chemistry", "round": 3} +{"url": "https://food.r-biopharm.com/products/ridascreen-tetracyclin-2/", "date": "2019-02-15T21:18:08Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-09/segments/1550247479159.2/warc/CC-MAIN-20190215204316-20190215230316-00059.warc.gz", "language_score": 0.8458997011184692, "token_count": 264, "dump": "CC-MAIN-2019-09", "global_id": "webtext-fineweb__CC-MAIN-2019-09__0__244030475", "lang": "en", "text": "RIDASCREEN® Tetracyclin is a competitive enzyme immunoassay for the quantitative analysis of tetracyclins in milk, milk powder, cheese, butter, dairy products (curd, yoghurt (plain/with fruits), kefir, cream, sour cream) honey, meat, sausage, fish, shrimp and whole egg.\n1948 aureomycin (chlortetracycline) was isolated by Duggan as a metabolite of the actinomyces species streptomycec aureofaciens. This was the first antibiotic substance of the group of tetracyclines. In Germany tetracycline, chlortetracycline and oxytetracycline are authorized for veterinary use. Therefore health risks for the consumer can occur. In all animal species which are used for food production tetracycline residues (the sum of mother substance and the 4-epimer) are limited in the EU law, commission regulation (EU) No 37/2010 with the following limits: 100 ppb in muscle and in milk.\n|Test format||Microtiter plate with 96 wells (12 strips with 8 removable wells each)|\n|Incubation time||1 h 30 min|", "domain": "chemistry", "round": 3} +{"url": "https://epublications.vu.lt/object/elaba:71908491/", "date": "2023-12-01T00:33:27Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100258.29/warc/CC-MAIN-20231130225634-20231201015634-00739.warc.gz", "language_score": 0.9196531772613525, "token_count": 328, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__255589695", "lang": "en", "text": "||Future light-based quantum technologies will depend on generation and manipulation of single photons, thus any quantum device will contain one crucial component within – single-photon emitter. So far, among the frontrunners are solid-state single-photon emitters, and they are expected to play an essential role in a plethora of quantum tasks. The recent discovery that hexagonal boron nitride can host robust, narrow-linewidth, bright, photostable, and indistinguishable single-photon sources operating at room temperature and above has sparked interest in this material. This Thesis synthesizes the results of theoretical work on the understanding the role of point defects in hexagonal boron nitride, in particular for the observed single-photon emission, by performing first-principles calculations. A significant step forward in the study was provided by giving a broad and comprehensive picture of the defect chemistry in hexagonal boron nitride. The author of this Thesis ensured a correct treatment of defect physics, and thereby illustrated ability to predict and assign microscopic identity of single-photon emitters in hexagonal boron nitride on scales unreachable for the experiment, using a purely first-principles approach. Physical model for quenching of 2 eV single-photon emission in this material was proposed. The author of this Thesis unpretentiously believes that the study covered in the last chapter of Thesis has also made its small contribution towards a more in-depth understanding of ultraviolet single-photon emission in hexagonal boron nitride by giving convincing explanations for obtained results.", "domain": "chemistry", "round": 3} +{"url": "https://www.cellsignal.com/products/antibody-conjugates/irak1-d51g7-rabbit-mab-pe-conjugate/77143", "date": "2019-08-17T20:40:38Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-35/segments/1566027312025.20/warc/CC-MAIN-20190817203056-20190817225056-00380.warc.gz", "language_score": 0.8045804500579834, "token_count": 587, "dump": "CC-MAIN-2019-35", "global_id": "webtext-fineweb__CC-MAIN-2019-35__0__42701626", "lang": "en", "text": "Flow cytometric analysis of wild type (+/+) 293T cells (green) or IRAK1 knockout (-/-) (blue) using IRAK1 (D51G7) Rabbit mAb (PE Conjugate).\n|REACTIVITY||H M Mk|\nThis Cell Signaling Technology antibody is conjugated to phycoerythrin (PE) and tested in-house for direct flow cytometry analysis in human cells. This antibody is expected to exhibit the same species cross-reactivity as the unconjugated IRAK1 (D51G7) Rabbit mAb #4504.\nSupplied in PBS (pH 7.2), less than 0.1% sodium azide and 2 mg/ml BSA. Store at 4°C. Do not aliquot the antibodies. Protect from light. Do not freeze.\nNOTE: Prepare solutions with reverse osmosis deionized (RODI) or equivalent grade water.\nNOTE: If using whole blood, lyse red blood cells and wash by centrifugation prior to fixation.\nposted July 2009\nrevised June 2017\nProtocol Id: 407\nIRAK1 (D51G7) Rabbit mAb (PE Conjugate) detects endogenous levels of total IRAK1 protein.Species Reactivity:\nHuman, Mouse, Monkey\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxyl terminus of mouse IRAK1.\nInterleukin-1 (IL-1) receptor-associated kinase (IRAK) is a serine/threonine-specific kinase that can be coprecipitated in an IL-1-inducible manner with the IL-1 receptor (1). The mammalian family of IRAK molecules contains four members (IRAK1, IRAK2, IRAK3/IRAK-M, and IRAK4). The binding of IL-1 to IL-1 receptor type I (IL-1RI) initiates the formation of a complex that includes IL-1RI, AcP, MyD88, and IRAKs (2). IRAK undergoes autophosphorylation shortly after IL-1 stimulation. The subsequent events involve IRAK dissociation from the IL-1RI complex, its ubiquitination, and its association with two membrane-bound proteins: TAB2 and TRAF6. The resulting IRAK-TRAF6-TAB2 complex is then released into the cytoplasm where it activates protein kinase cascades, including TAK1, IKKs, and the stress-activated kinases (3).\nExplore pathways + proteins related to this product.\nCell Signaling Technology is a trademark of Cell Signaling Technology, Inc.", "domain": "chemistry", "round": 3} +{"url": "http://dels.nas.edu/Report/Seventeenth-Interim-Report-Committee/12870", "date": "2020-07-03T19:56:22Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-29/segments/1593655882934.6/warc/CC-MAIN-20200703184459-20200703214459-00595.warc.gz", "language_score": 0.9020270705223083, "token_count": 344, "dump": "CC-MAIN-2020-29", "global_id": "webtext-fineweb__CC-MAIN-2020-29__0__150390662", "lang": "en", "text": "Seventeenth Interim Report of the Committee on Acute Exposure Guideline Levels (2010)Board on Environmental Studies and Toxicology\nEach report is produced by a committee of experts selected by the Academy to address a particular statement of task and is subject to a rigorous, independent peer review; while the reports represent views of the committee, they also are endorsed by the Academy. Learn more on our expert consensus reports.\nFormed in 1995 by EPA, several other federal and state agencies, and several private organizations, the National Advisory Committee on Acute Exposure Guideline Levels for Hazardous Substances (referred to as the NAC) develops, reviews, and approves acute exposure guideline levels (AEGLs) for up to 400 extremely hazardous substances (EHSs). AEGLs have a broad array of potential applications for federal, state, and local governments and for the private sector. They are necessary for prevention and emergency-response planning for potential releases of EHSs, either from accidents or as a result of terrorist activities. This report includes an assessment of the NAC's draft AEGLs documents for the following 17 chemicals: acetaldehyde, arsenic trioxide, benzene, 1,3-butadiene, butane, chloroacetaldehyde, chlorobenzene, hexane, jet propellant fuels 5 and 8, ketene, methylene chloride, oleum, propane, propionaldehyde, sulfuric acid, sulfur trioxide, and trichloroethylene. The report also summarizes the committee's conclusions and recommendations for improving the Standing Operating Procedures for Developing Acute Exposure Guideline Levels for Hazardous Substances, published in 2001.", "domain": "chemistry", "round": 3} +{"url": "https://apps.dtic.mil/sti/citations/ADA595612", "date": "2022-01-18T17:16:16Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-05/segments/1642320300934.87/warc/CC-MAIN-20220118152809-20220118182809-00019.warc.gz", "language_score": 0.9327608942985535, "token_count": 324, "dump": "CC-MAIN-2022-05", "global_id": "webtext-fineweb__CC-MAIN-2022-05__0__20125816", "lang": "en", "text": "Iodine Plasma Species Measurements in a Hall Effect Thruster Plume\nViewgraph, May-Jun 2013\nAIR FORCE RESEARCH LAB EDWARDS AFB CA\nPagination or Media Count:\nThe plasma plume from a 200 W Hall Effect Thruster fueled by iodine vapor was analyzed. The plasma source included a laboratory propellant feed system and a laboratory model Hall thruster powered by a breadboard power processing unit. The hollow cathode was fed with xenon. The distribution of iodine ions was measured with an ExB probe, an electrostatic analyzer ESA, and a combined ESAExB probe. The distribution of xenon ions was also measured. Multiply charge species were detected with both iodine and xenon. Significant populations of diatomic iodine ions were also detected. The dimer fraction was found to vary with operating conditions and angular distance from the beam centroid. The greatest populations of high energy dimers were observed at lower discharge current, and at angles of 30-50 degrees from the beam centroid. At one operating condition, the high energy dimer fraction was approximately 20 by mass in this region. Significant dimer fractions could increase thrust to power by useful amounts at the cost of some overall efficiency.\n- Electricity and Magnetism\n- Combustion and Ignition\n- Electric and Ion Propulsion", "domain": "chemistry", "round": 3} +{"url": "https://pl.wessling-group.com/en/services/environmental-analysis/water-analysis/drinking-water", "date": "2023-05-28T18:30:11Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-23/segments/1685224644506.21/warc/CC-MAIN-20230528182446-20230528212446-00124.warc.gz", "language_score": 0.9270420670509338, "token_count": 279, "dump": "CC-MAIN-2023-23", "global_id": "webtext-fineweb__CC-MAIN-2023-23__0__198425879", "lang": "en", "text": "Due to its nature, drinking water has the lowest tolerance for pollutant concentrations and its frequent, detailed analysis is necessary.\nMore and more often we can hear that tap water is better or as good as bottled water. To make it true a proper way of its monitoring is necessary. Water supplied from devices and cisterns, introduced into unit packages, used in the production plant, food circulation, as part of business activities or in public utility buildings, collective and residential buildings, as well as water supplied from individual water intakes, and that in land, air or water means of transport concern restrictive requirements and absolute constant control.\nThe regulation which contains a general information about drinking water, choosing places for sampling and testing frequency as well as the requirements of drinking water quality, the scope and method of analysis is:\nRozporządzenie Ministra Zdrowia w sprawie jakości wody przeznaczonej do spożycia przez ludzi\nWESSLING Polska performs a comprehensive service of sampling and analyzing drinking water samples in accordance to the applicable regulation.\nWhat is important, drinking water samples should be sampled by an authorized person. The quality system used by our laboratory has been officially approved by the Sanitary Inspection. This officially entitles us to sample and analyze drinking water.", "domain": "chemistry", "round": 3} +{"url": "http://www.harvestfishandpet.com/red-sea-reef-foundation-b-500ml-kh-alkalinity", "date": "2019-04-19T10:56:15Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-18/segments/1555578527566.44/warc/CC-MAIN-20190419101239-20190419123239-00500.warc.gz", "language_score": 0.8855156302452087, "token_count": 546, "dump": "CC-MAIN-2019-18", "global_id": "webtext-fineweb__CC-MAIN-2019-18__0__141995963", "lang": "en", "text": "Red Sea’s KH/ALKALINITY is a complex of carbonate and other buffers present in seawater that maintain proper alkalinity and pH, and is part of Red Sea’s complete Reef Care program\n- Carbonate & buffer complex for balanced formation of Coral Skeleton\n- Promote coral health and growth\n- Maintain proper alkalinity and pH\n- Liquid supplement: 1ml will raise the Alk level of 100 liters (25 gal) by 0.036 meq/l (0.1dKH)Powder supplement: 1g will raise the Alk level of 100 liters (25 gal) 0.12 meq/l (0.33dKH)1 kg will make 10L of stock solution\nQ: Can I add all Foundation Elements at once?\nA: No. It is important that the Foundation Elements are dosed at least 10 minutes apart, in order to prevent any precipitation issues. The correct order to dose in is: Magnesium (Foundation C) then Carbonate (Foundation B) and Calcium (Foundation A)\nQ: Should I use substrate?\nA: You can set up your reef tank with or without a substrate at the bottom. We recommend using substrate, ideally an Aragonite-based substrate as it helps keep the water chemistry balanced. As Aragonite dissolves slowly in water, it releases calcium ions and carbonates that help maintain proper pH and alkalinity for good coral growth. In an established tank, when the substrate matures, it takes on the characteristics of “live sand” inhabited by millions of microorganisms. These creatures promote a successful aquarium, aiding the biological filtration processes of nitrification, denitrification and the consumption/decomposition of uneaten food. The substrate also provides a natural habitat for small worms and crustaceans that help clean the tank from detritus and play a major role in the delicate ecosystem’s food chain.\nQ: Why can't I just use Foundation ABC+ without using the individual Foundation A, B, & C Supplements?\nA: Reef Foundation ABC+ is formulated according to the expected Foundation Element uptake of an “average” reef aquarium. In practice no 2 aquariums are identical and therefore the actual uptake will differ from the ABC+ formula however the differences will only be significant over a period of time. Using ABC+ reduces the number of supplements that need to be added on a daily basis but it is still necessary to do a weekly adjustment with all of the individual supplements to keep all of the Foundation Elements at optimal levels.", "domain": "chemistry", "round": 3} +{"url": "https://crbdiscovery.com/discovery-antibodies/anti-hrva16-vpg-diuridylated-antibody-crb2005637/", "date": "2023-09-22T21:45:51Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233506423.70/warc/CC-MAIN-20230922202444-20230922232444-00708.warc.gz", "language_score": 0.8468642234802246, "token_count": 668, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__285730942", "lang": "en", "text": "Anti-HRV-A16 VPg di-uridylylated antibody\nAnti-HRVA16 VPg di-uridylylated antibody raised against the N-terminal of the VPg peptide in the di-uridylylated form. VPg is crucial for Human rhinovirus (HRV) polymerisation.\nCatalogue number crb2005637 Antibody Anti-HRV-A16 VPg di-uridylylated antibody Antigen Peptide KLH conjugated synthetic peptide crb1200844 Aliases VPg, Anti–VPg-pU(pU) Cross-Reactivity human rhinovirus (HRV) Target Protein Species human rhinovirus (HRV) Host Species Anti-Rabbit Antibody Type Polyclonal Concentration 0.5 mg/ml (R1G) 0.2 mg/ml (R2G) Validation ELISA (1:1000) Target HRV-A16 VPg Storage Stabilisers The product should be stored at -20°C for for short term storage and long term storage. Avoid repeated freeze/ thaw cycles. Disease Area Asthma, COPD Specificity Protein Post-translational Modification Uridylation Storage The product should be stored at -20°C for for short term storage and long term storage. Avoid repeated freeze/ thaw cycles. Citations\nGingras R, Mekhssian K, Fenwick C, White PW, Thibeault D. (2104). Human rhinovirus VPg uridylylation AlphaScreen for high-throughput screening. J Biomol Screen. Feb;19(2):259-69. PMID: 23813021.\nHuman rhinoviruses (HRV) are the leading cause of the common cold, asthma, and chronic obstructive pulmonary disease exacerbations. This has led to the search for therapies that inhibit the HRV-induced inflammatory response or prevent viral infectivity. There is significant genetic diversity in the HRV family hence a lack of natural immunity, which also hampers the development of vaccines; HRV genetic diversity also is the reason there are no available broad-spectrum antivirals with direct action on HRV. A putative strategy is the identification of rhinovirus replication inhibitors targeting the polymerase activity. An initial step in HRV replication is the conjugation of viral peptide VPg uridine nucleotides to substrates, which serve as the primer for polymerisation. An antibody was raised against virus HRV-A16 peptide VPg N-terminal (GPYSGEPKPK) in the di-uridylylated form. The HRVA16 di-uridylylated antibody was crucial. It has been possible to reconstitute the uridylylation reaction to allow high-throughput screening and use the HRV-A16 VPg di-uridylylated antibody in the assay to identify novel inhibitors of human rhinovirus (HRV) VPg uridylylation with potential uses in the future as clinical antiviral drugs.", "domain": "chemistry", "round": 3} +{"url": "http://www.antibodies-online.com/m-phase-pathway-68/ppp1ca-antibody-4617/", "date": "2017-11-22T20:26:11Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-47/segments/1510934806660.82/warc/CC-MAIN-20171122194844-20171122214844-00218.warc.gz", "language_score": 0.9190000891685486, "token_count": 2185, "dump": "CC-MAIN-2017-47", "global_id": "webtext-fineweb__CC-MAIN-2017-47__0__23849079", "lang": "en", "text": "Use your antibodies-online credentials, if available.\nNo Products on your Comparison List.\nYour basket is empty.\nFind out more\nShow all species\nShow all synonyms\nSelect your species and application\nanti-Mouse (Murine) Antibodies:\nanti-Rat (Rattus) Antibodies:\nGo to our pre-filtered search.\nHuman Monoclonal PPP1CA Primary Antibody for ELISA, WB - ABIN969360\nChen, Kesler, Paschal, Balk: Androgen receptor phosphorylation and activity are regulated by an association with protein phosphatase 1. in The Journal of biological chemistry 2009\nShow all 2 Pubmed References\nHuman Monoclonal PPP1CA Primary Antibody for ELISA, WB - ABIN969359\nLuo, Peterson, Garcia, Coombs, Kofahl, Heinrich, Shabanowitz, Hunt, Yost, Virshup: Protein phosphatase 1 regulates assembly and function of the beta-catenin degradation complex. in The EMBO journal 2007\nShow all 2 Pubmed References\nData, including data from studies using transgenic/knockout mice, suggest that Ppp1ca and Gnb1 (show GNB1 Antibodies) interact in quiescent platelets; then, Ppp1ca and Plcb3 (show PLCB3 Antibodies) interact during platelet aggregation; thus, Gnb1 (show GNB1 Antibodies) enlists Ppp1ca to modulate G protein-coupled receptor (show GPR34 Antibodies) signaling. (Ppp1ca = protein phosphatase 1 (show PPP1CB Antibodies), catalytic subunit alpha; Gnb1 (show GNB1 Antibodies) = guanine nucleotide-binding protein (show TRIM23 Antibodies), subunit beta-1; Plcb3 (show PLCB3 Antibodies) = phospholipase C (show PLC Antibodies), subunit beta-3)\nfindings demonstrate a novel regulatory circuit in which STING and TBK1 (show TBK1 Antibodies) reciprocally regulate each other to enable efficient antiviral signaling activation, and PPM1A (show PPM1A Antibodies) dephosphorylates STING and TBK1 (show TBK1 Antibodies)\nthe studies presented here position PPM1A (show PPM1A Antibodies) as a new player in the wound healing-inflammation-angiogenesis axis in mouse, reveal its crucial role in homeostasis on injury, and highlight its potential as a therapeutic mediator in pathologic conditions\nAng (show ANG Antibodies) IV functions via regulating the activity of PP1 (show PPP1CC Antibodies)\na nuclear envelope-localized mechanism of inactivating TGF-beta (show TGFB1 Antibodies) signaling in which MAN1 (show LEMD3 Antibodies) competes with transcription factors for binding to Smad2 (show SMAD2 Antibodies) and Smad3 (show SMAD3 Antibodies) and facilitates their dephosphorylation by PPM1A (show PPM1A Antibodies).\nAlthough a non-myristoylated mutation (G2A (show GPR132 Antibodies)) of PPM1A (show PPM1A Antibodies) and PPM1B (show PPM1B Antibodies) prevented membrane association, this relocalization did not likely cause the decreased activity towards AMPKalpha (show GRK4 Antibodies).\nwe found that PPM1A (show PPM1A Antibodies) mRNA is synthesized at the beginning of the maturation process and remains elevated in the mature oocytes, promoting the accumulation of PPM1A (show PPM1A Antibodies) protein\nCell surface expression of the major amyloid-beta peptide (Abeta (show APP Antibodies))-degrading enzyme, neprilysin (show MME Antibodies), depends on phosphorylation by mitogen-activated protein kinase (show MAPK1 Antibodies)/extracellular signal-regulated kinase kinase (MEK (show MDK Antibodies)) and dephosphorylation by protein phosphatase 1a (show PPM1A Antibodies).\nanalysis of selective regulation of NR2B (show GRIN2B Antibodies) by protein phosphatase-1 (show PPP1CB Antibodies) for the control of the NMDA receptor in neuroprotection\nProtein phosphatase PPM1A (show PPM1A Antibodies) regulates the nuclear export of Smad2 (show SMAD2 Antibodies)/3 through targeting nuclear exporter RanBP3 (show RANBP3 Antibodies).\nestablish PPM1A (show PPM1A Antibodies) as a novel repressor of the SMAD3 (show SMAD3 Antibodies) pathway in renal fibrosis\nData, including data from studies using cells from knockout mice, suggest that gasotransmitter H(2)S up-regulates eIF2a (show EIF2S1 Antibodies) phosphorylation by inhibiting PPP1CA via persulfidation, which in turn leads to transient suppression of global translation and activation of Atf4 (show ATF4 Antibodies) expression. (eIF2a (show EIF2S1 Antibodies) = eukaryotic initiation factor-2alpha (show EIF2S1 Antibodies); PPP1CA = protein phosphatase 1 catalytic subunit alpha; Atf4 (show ATF4 Antibodies) = activating transcription factor 4 (show ATF4 Antibodies))\nReport a tumor-suppressive function of PPM1A (show PPM1A Antibodies) and an independent relationship to Smad4 (show SMAD4 Antibodies) in pancreatic ductal adenocarcinoma.\nProtein phosphatase 1 (show PPP1CB Antibodies) (PP1 (show PPA1 Antibodies)) forms stable complexes with PP1 (show PPA1 Antibodies)-interacting proteins (PIPs (show GPRASP1 Antibodies)) that guide the phosphatase throughout its life cycle and control its fate and function.\nThe authors found that RNA recognition motif 1 (RRM1 (show RRM1 Antibodies)) in SRSF1 (show SRSF1 Antibodies) binds PP1 (show PPA1 Antibodies) and represses its catalytic function through an allosteric mechanism.\nthis study shows a pivotal role for PP1 (show PPA1 Antibodies) in impeding IRF7 (show IRF7 Antibodies)-mediated IFN-alpha (show IFNA Antibodies) production in host immune responses\nhydrogen/deuterium exchange-mass spectrometry and molecular dynamics to characterize conformational changes in PP2Calpha (show PPM1A Antibodies) between the active and inactive states\nIn a nested case control study of ischemic stroke, there was an epigenome-wide association for cg04985020 (PPM1A (show PPM1A Antibodies); P=1.78x10(-07)) with vascular recurrence in patients treated with aspirin.\nThe data support a model where Cdc7 (show CDC7 Antibodies) (de)phosphorylation is the molecular switch for the activation and inactivation of DNA replication in mitosis, directly connecting Cdc7 (show CDC7 Antibodies) and PP1a/Cdk1 (show CDK1 Antibodies) to the regulation of once-per-cell cycle DNA replication in mammalian cells.\nThese results indicate that PP1 (show PPA1 Antibodies) is recruited to the extracellular calcium-dependent E-cadherin (show CDH1 Antibodies)-catenin-PIP5K1a (show PIP5K1A Antibodies) complex in the plasma membrane to activate PIP5K1a (show PIP5K1A Antibodies), which is required for PLC (show HSPG2 Antibodies)-g1 activation leading to keratinocyte differentiation.\nThe protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described.\nProtein phosphatase type 1 alpha, catalytic subunit\n, protein phosphatase 1, catalytic subunit, alpha isoform\n, serine/threonine-protein phosphatase PP1-alpha catalytic subunit\n, protein phosphatase 1, catalytic subunit, alpha\n, serine/threonine protein phosphatase PP1-alpha 1 catalytic subunit\n, protein phosphatase-1d\n, protein phosphatase 1, catalytic subunit, beta isoform\n, protein phosphatase-1a\n, serine/threonine-protein phosphatase PP1-beta catalytic subunit\n, Mpp alpha\n, protein phosphatase 1A\n, protein phosphatase 2C isoform alpha\n, protein phosphatase IA\n, protein phosphatase 1A (formerly 2C), magnesium-dependent, alpha isoform\n, protein phosphatase 2C alpha", "domain": "chemistry", "round": 3} +{"url": "https://www.astm.org/Standards/D5205.htm", "date": "2021-09-26T10:38:34Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-39/segments/1631780057857.27/warc/CC-MAIN-20210926083818-20210926113818-00697.warc.gz", "language_score": 0.8418180346488953, "token_count": 1077, "dump": "CC-MAIN-2021-39", "global_id": "webtext-fineweb__CC-MAIN-2021-39__0__186863296", "lang": "en", "text": "| ||Format||Pages||Price|| |\n|7||$54.00||  ADD TO CART|\n|Hardcopy (shipping and handling)||7||$54.00||  ADD TO CART|\n|Standard + Redline PDF Bundle||14||$64.00||  ADD TO CART|\nThis classification system covers unfilled, filled, and reinforced polyetherimide materials suitable for injection molding and extrusion. Unfilled polyetherimide materials are classified into groups according to their composition. These groups are subdivided into classes and grades. The plastic compositions shall be uniform and shall conform to the requirements specified. Determine the properties enumerated in this classification system using the referenced test methods.\nThis abstract is a brief summary of the referenced standard. It is informational only and not an official part of the standard; the full text of the standard itself must be referred to for its use and application. ASTM does not give any warranty express or implied or make any representation that the contents of this abstract are accurate, complete or up to date.\n1.1 This classification system covers unfilled, filled, and reinforced polyetherimide materials suitable for injection molding and extrusion.\n1.2 This classification system is not intended for the selection of materials, but only as a means to call out plastic materials to be used for the manufacture of parts. The selection of these materials is to be made by personnel with expertise in the plastics field where the environment, inherent properties of the materials, performance of the parts, part design, manufacturing process, and economics are considered.\n1.3 The properties included in this classification system are those required to identify the compositions covered. Other requirements necessary to identify particular characteristics important to specialized applications are to be specified by using suffixes as given in Section .\n1.4 Polyetherimide materials, being thermoplastic, are reprocessable and recyclable. This classification system allows for the use of those polyetherimide materials, provided that all specific requirements of this classification system are met.\n1.5 The values stated in SI units are to be regarded as standard. No other units of measurement are included in this standard.\n1.6 The following precautionary caveat pertains only to the test methods portion, Section , of this classification system: This standard does not purport to address all of the safety concerns, if any, associated with its use. It is the responsibility of the user of this standard to establish appropriate safety and health practices and determine the applicability of regulatory limitations prior to use. Specific precautionary statements are given at the end of .\nNote 1: There is no known ISO equivalent to this standard.\n2. Referenced Documents (purchase separately) The documents listed below are referenced within the subject standard but are not provided as part of the standard.\nD149 Test Method for Dielectric Breakdown Voltage and Dielectric Strength of Solid Electrical Insulating Materials at Commercial Power Frequencies\nD150 Test Methods for AC Loss Characteristics and Permittivity (Dielectric Constant) of Solid Electrical Insulation\nD257 Test Methods for DC Resistance or Conductance of Insulating Materials\nD618 Practice for Conditioning Plastics for Testing\nD638 Test Method for Tensile Properties of Plastics\nD648 Test Method for Deflection Temperature of Plastics Under Flexural Load in the Edgewise Position\nD790 Test Methods for Flexural Properties of Unreinforced and Reinforced Plastics and Electrical Insulating Materials\nD792 Test Methods for Density and Specific Gravity (Relative Density) of Plastics by Displacement\nD883 Terminology Relating to Plastics\nD1238 Test Method for Melt Flow Rates of Thermoplastics by Extrusion Plastometer\nD1600 Terminology for Abbreviated Terms Relating to Plastics\nD2863 Test Method for Measuring the Minimum Oxygen Concentration to Support Candle-Like Combustion of Plastics (Oxygen Index)\nD3641 Practice for Injection Molding Test Specimens of Thermoplastic Molding and Extrusion Materials\nD3892 Practice for Packaging/Packing of Plastics\nD4000 Classification System for Specifying Plastic Materials\nD5630 Test Method for Ash Content in Plastics\nD5740 Guide for Writing Material Standards in the Classification Format\nD7209 Guide for Waste Reduction, Resource Recovery, and Use of Recycled Polymeric Materials and Products\nE29 Practice for Using Significant Digits in Test Data to Determine Conformance with Specifications\nE662 Test Method for Specific Optical Density of Smoke Generated by Solid Materials\nUnderwriters Laboratories StandardsUL 94\nICS Number Code 83.080.20 (Thermoplastic materials)\nUNSPSC Code 13111014(Polyetherimide resin)\n|Link to Active (This link will always route to the current Active version of the standard.)|\nASTM D5205-16, Standard Classification System and Basis for Specification for Polyetherimide (PEI) Materials, ASTM International, West Conshohocken, PA, 2016, www.astm.orgBack to Top", "domain": "chemistry", "round": 3} +{"url": "https://rd.springer.com/protocol/10.1007%2F978-1-4939-9424-3_3", "date": "2019-06-16T13:33:47Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-26/segments/1560627998238.28/warc/CC-MAIN-20190616122738-20190616144738-00549.warc.gz", "language_score": 0.7475298643112183, "token_count": 1128, "dump": "CC-MAIN-2019-26", "global_id": "webtext-fineweb__CC-MAIN-2019-26__0__160341745", "lang": "en", "text": "Enhanced Immunoaffinity Purification of Human Neutrophil Flavocytochrome B for Structure Determination by Electron Microscopy\nDetermination of the structure of human neutrophil (PMN) flavocytochrome b (Cytb) is a necessary step for the understanding of the structure-function essentials of NADPH oxidase activity. This understanding is crucial for structure-driven therapeutic approaches addressing control of inflammation and infection. Our work on purification and sample preparation of Cytb has facilitated progress toward the goal of structure determination. Here we describe exploiting immunoaffinity purification of Cytb for initial examination of its size and shape by a combination of classical and cryoelectron microscopic (EM) methods. For these evaluations, we used conventional negative-stain transmission electron microscopy (TEM) to examine both detergent-solubilized Cytb as single particles and Cytb in phosphatidylcholine reconstituted membrane vesicles as densely packed random, partially ordered, and subcrystalline arrays. In preliminary trials, we also examined single particles by cryoelectron microscopy (cryoEM) methods. We conclude that Cytb in detergent and reconstituted in membrane is a relatively compact, symmetrical protein of about 100 Å in maximum dimension. The negative stain, preliminary cryoEM, and crude molecular models suggest that the protein is probably a heterotetramer of two p22phox and gp91phox subunits in both detergent micelles and membrane vesicles. This exploratory study also suggests that high-resolution 2D electron microscopic approaches may be accessible to human material collected from single donors.\nKey wordsimmunoaffinity purification NOX2 flavocytochrome b electron microscopy cryoEM 2D membrane reconstitution negative stain mAb CS9\nWe thank the Montana State University College of Letters and Sciences for funding the Sabbatical leave during the 2007–2008 academic year for AJJ during which the initial phases of this work were carried out. We also acknowledge the PHS grant 5R01AI26711 and the ARRA supplement for support during the subsequent period. Thanks also go to J. Quispe, B. Carragher, and C. Potter of the National Resource for Automated Molecular Microscopy at the Scripps Research Institute and S. Ludtke of the Baylor College of Medicine for help in obtaining and processing the cryoEM images. Lastly, special thanks go to the Thermal Biology Institute, NSF EPSCOR, and The Montana Nanotechnology Facility (MONT) for funding the negative-stain electron microscopy time.\n- 5.Klebanoff SJ (1999) Oxygen metabolites from phagocytes. In: Gallin JI, Goldstein IM, Snyderman R (eds) Inflammation: basic principle and clinical correlates. Lippincott Wiliams and Wilkins, Philadelphia, PA, pp 721–768Google Scholar\n- 8.Beckman JS, Chen J, Ischiropoulos H, Crow JP (1994) Oxidative chemistry of peroxynitrite. Methods Enzymol 233:229–240Google Scholar\n- 9.Anderson MM, Hazen SL, Hsu FF, Heinecke JW (1997) Human neutrophils employ the myeloperoxidase-hydrogen peroxide-chloride system to convert hydroxy-amino acids amino acids into glycoaldehyde, 2-hydroxy-propanol, and acrolein. A mechanism for the generation of highly reactive alpha-hydroxy and alpha-beta unsaturated aldehydes by phagocytes at site of inflammation. J Clin Invest 99(424):432Google Scholar\n- 26.Burritt JB, DeLeo FR, McDonald CL, Prigge JR, Dinauer MC, Nakamura M, Nauseef WM, Jesaitis AJ (2001) Phage display epitope mapping of human neutrophil flavocytochrome b558. Identification of two juxtaposed extracellular domains. J Biol Chem 276(3):2053–2061. https://doi.org/10.1074/jbc.M006236200 CrossRefGoogle Scholar\n- 32.Taylor RM, Lord CI, Riesselman MH, Gripentrog JM, Leto TL, McPhail LC, Berdichevsky Y, Pick E, Jesaitis AJ (2007) Characterization of surface structure and p47phox SH3 domain-mediated conformational changes for human neutrophil flavocytochrome b. Biochemistry 46(49):14291–14304CrossRefGoogle Scholar\n- 33.Taylor RM, Burritt JB, Baniulis D, Foubert TR, Lord CI, Dinauer MC, Parkos CA, Jesaitis AJ (2004) Site-specific inhibitors of NADPH oxidase activity and structural probes of flavocytochrome b: characterization of six monoclonal antibodies to the p22phox subunit. J Immunol 173(12):7349–7357Google Scholar\n- 34.Kuhlbrandt W (1994) Two-dimensional crystallization of membrane proteins: a practical guide. In: Hunte CVJG, Schragger H (eds) Membrane protein purification and crystalization. Academic Press, San Diego, pp 253–280Google Scholar", "domain": "chemistry", "round": 3} +{"url": "https://www.vertexlubricants.co.nz/product/heat-transfer-fluid-32/", "date": "2023-12-07T03:24:15Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-50/segments/1700679100632.0/warc/CC-MAIN-20231207022257-20231207052257-00571.warc.gz", "language_score": 0.9136809706687927, "token_count": 356, "dump": "CC-MAIN-2023-50", "global_id": "webtext-fineweb__CC-MAIN-2023-50__0__257645927", "lang": "en", "text": "Vertex Heat Transfer Fluid 32 is a premium quality heat transfer oil intended for use in closed indirect heating systems with expansion tanks temperatures up to 340°C. Designed for heating by heat exchange, all types of systems (piping, pumps, etc…). Heating of heat treatment baths, reaction vessels, furnaces, dies, cement works, paper mills, timber industry, etc.\nVertex Heat Transfer Fluid 32 is designed for use in :\n- Heating of domestic and industrial premises.\n- Production of steam and hot water.\n- Air conditioning.\n- Temperature control for storage bins.\n- Heating by heat exchange.\n- All types of systems (piping, pumps, etc…).\n- Heating of heat treatment baths, autoclaves, reaction vessels, furnaces, dies, tunnel driers, injection moulding machines, etc.\n- Manufacturing processes (cement works, paper mills, timber industry, etc…).\nVertex Heat Transfer Fluid 32 offers the following benefits:\n- Compared to conventional fluids Vertex Heat Transfer Fluid 32 has an excellent resistance to thermal cracking.\n- Low viscosity allows fast rise in flow during starting periods.\nStatic and dynamic deterioration tests have shown that at test temperatures exceeding 340 °C, the following results were obtained using Vertex Heat Transfer Fluid 32 in comparison with other heat transfer mediums available:\n- weight of deposits was 10 to 20 times lower\n- rate of production of light fractions was cut by half.\nThe joint effect of these advantages was that the life of the fluid itself and that of the installation were increased.\nPlease contact Lubricants NZ Technical Department for more detailed information. email@example.com", "domain": "chemistry", "round": 3} +{"url": "https://sg.mpbio.com/07i554202-rheumatoid-factor-igm-elisa-kit", "date": "2020-01-22T14:11:22Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-05/segments/1579250607118.51/warc/CC-MAIN-20200122131612-20200122160612-00318.warc.gz", "language_score": 0.6520618200302124, "token_count": 344, "dump": "CC-MAIN-2020-05", "global_id": "webtext-fineweb__CC-MAIN-2020-05__0__2025214", "lang": "en", "text": "Rheumatoid Factor IgM ELISA Kit (CE)\nThe Rheumatoid Factor IgM ELISA Kit is intended for the measurement of IgM antibodies to Rheumatoid Factor in a sample.\nAvailable in US for Research Use Only. CE Marked for IVD use outside the United States.\n|Analyte / Target||Rheumatoid Factor antibodies|\n|Diagnostic Solutions||Autoimmune Disease|\n|Disease Screened||Rheumatoid Factor|\n|Kit or Assay Type||Enzyme-linked Immunosorbent Assay|\n|Pack Size||96 Wells|\n|Product Families Description||The Rheumatoid Factor ELISA Kit is intended for the measurement of IgG, IgA, or IgM antibodies to Rheumatoid Factor in a sample.|\n|Product Overview||The kit is ready to use and includes the following components: Microtiter Strips, 4 standards, two controls, Enzyme Conjugate, Substrate, Stop Solution, Sample Diluent, Washing Buffer, Plastic Foils, and a Plastic Bag. Kit has a lead time of 3-4 weeks from order receipt.|\n|Recommended Replacement For||07I554102 | 07I554002|\n|Regulatory Compliance||CE Marked|\n|Sample Volume||100 uL of 1:101 diluted sample|\n|Standards||0, 50, 100, 200 IU/mL|\n|Storage and Handling||Store at 2 - 8C|\n|Usage Statement||Available in US for Research Use Only. CE Marked for IVD use outside the United States.|", "domain": "chemistry", "round": 3} +{"url": "https://www.cephamls.com/stat6phospho-tyr641-antibody/", "date": "2023-04-02T05:06:10Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-14/segments/1679296950383.8/warc/CC-MAIN-20230402043600-20230402073600-00112.warc.gz", "language_score": 0.7583104372024536, "token_count": 483, "dump": "CC-MAIN-2023-14", "global_id": "webtext-fineweb__CC-MAIN-2023-14__0__106603202", "lang": "en", "text": "NCBI Protein: NP_003144.3\nPeptide sequence around phosphorylation site of Tyrosine 641 (R-G-Y(p)-V-P) derived from Human STAT6.\nWB IHC Recommended dilution: Predicted MW: 110kd, Western blotting: 1:500~1:1000, Immunohistochemistry: 1:50~1:100,\nBackground / Function\nCarries out a dual function: signal transduction and activation of transcription. Involved in interleukin-4 signalling.Nelms K, et al. (1999) Annu Rev Immunol. 17:701-738.Malabarba M G, et al. (1996) Biochem. J. 319:865-872.Hou J, et al. (1994) Science. 265:1701-1706.Quelle F W, et al. (1995) Mol Cell Biol. 15: 3336-3343.Takeda K, et al. (1996) Nature. 380: 627-630.\nSupplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.\nShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.\nAntibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.", "domain": "chemistry", "round": 3} +{"url": "https://kingsunconcreteadmixtures.com/the-basic-situation-of-concrete-water-reducer-industry/", "date": "2024-04-17T21:31:36Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712296817181.55/warc/CC-MAIN-20240417204934-20240417234934-00246.warc.gz", "language_score": 0.931529700756073, "token_count": 583, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__4721439", "lang": "en", "text": "Concrete water reducer refers to an admixture that can reduce mixing water consumption and increase the strength of concrete under the conditions of constant workability and cement consumption, or save cement consumption under conditions of constant workability and strength.\nClassification of Concrete Water Reducer\nWater reducing admixtures are usually divided into: lignosulfonate water reducer, naphthalene based superplasticizer, melamine-based superplasticizers, sulfamate-based superplasticizers, fats family superplasticizer, polycarboxylate superplasticizer.\nThe Function of Water Reducing Admixture\nThe use of water reducing admixtures can save cement, reduce costs, shorten the construction period, improve the construction of concrete, and increase the quality and service life of buildings. It is of great significance in terms of energy saving, environmental protection, engineering economy, labor protection, etc. Its uses are mainly reflected in:\n- Without changing the ratio of various raw materials (except cement) and the strength of concrete, the amount of cement can be reduced. Adding 0.2%-0.5% of cement quality concrete water-reducing agent can save more than 15-30% of the amount of cement.\n- Without changing the ratio of various raw materials (except for water) and the slump of concrete, reducing the amount of water can greatly increase the strength of concrete. By reducing water, high-strength concrete of C100 can be poured.\n- Without changing the ratio of various raw materials, the rheology and plasticity of concrete can be greatly improved, so that concrete construction can be carried out by self-flowing, pumping, and without vibration, which can increase construction speed and reduce construction energy consumption.\n- Adding concrete superplasticizer can increase the life of concrete by more than one time, and prolong the normal service life of buildings by more than one time; reduce the shrinkage of concrete solidification, prevent cracks in concrete components, and improve frost resistance, which is beneficial in Winter construction.\nDevelopment Status of Concrete Water Reducer\nThe development of international water reducing admixtures has gone through three stages: the first-generation general water reducing admixture stage represented by wood calcium, the second-generation high-efficiency water reducer mainly represented by naphthalene series (mainly naphthalene sulfonate series, sulfonated melamine series, aliphatic series, sulfamate series, etc.) stage and the third-generation high-performance water reducing admixture stage represented by polycarboxylic acid series. At present, the domestic water reducer market is dominated by second-generation water reducers with three-generation water reducer coexisting, and the market share of polycarboxylic acid-based water reducing admixtures is increasing year by year.", "domain": "chemistry", "round": 3} +{"url": "https://jasenterprise.com/rotating-vibrating-screen.html", "date": "2021-06-21T20:23:03Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-25/segments/1623488289268.76/warc/CC-MAIN-20210621181810-20210621211810-00390.warc.gz", "language_score": 0.8008159399032593, "token_count": 253, "dump": "CC-MAIN-2021-25", "global_id": "webtext-fineweb__CC-MAIN-2021-25__0__94335909", "lang": "en", "text": "Jas enterprise An ISO 9001:2008 Quality System Certified company and leading Supplier and Manufacturer of Vibrating \" Rotary Screens exported to America, Canada Europe, Asian, African countries.\nThese rotating vibrating screens are durable use, easy maintenance, high capability. Our rotating and vibrating screens are most versatile machine in many industries like\n- Food Industry: Ground powders, spice powders, Sugar, Salt, Alkali, sodium glutamate (MSG) Glutamate, Starch,Powdered Milk, Yeast and Fruit Juice.\n- Chemical Industry: Resin, Pigment, Medicine, Grease, Extinction agent, Rubber and plastic.\n- Abrasive, Glass and ceramic Industry: Silicone Sand, Aluminum Oxide, Grinding Abrasive, Glass dust and fire-proof material.\n- Paper making Industry: Coated slurry, black and white liquor, padding fluid, waste liquid and waste water recycling.\n- Mechanical Industry: Casing Sand,Powder metallurgy, Electromagnetism material, Aluminum Powder, Metal Powder and Alloy.\n- Others: Carbon Black, Activated Carbon and pearl.\nEasy to use rotating vibrating screen which include:", "domain": "chemistry", "round": 3} +{"url": "http://www.woodpromotion.net/tag/falls-church-voc-testing", "date": "2018-05-26T13:29:10Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-22/segments/1526794867417.75/warc/CC-MAIN-20180526131802-20180526151802-00067.warc.gz", "language_score": 0.9456341862678528, "token_count": 762, "dump": "CC-MAIN-2018-22", "global_id": "webtext-fineweb__CC-MAIN-2018-22__0__5810973", "lang": "en", "text": "Introducing Volatile Organic Chemical Screening VOCs are provided with a big number of products numbering in the hundreds. The VOC screening that we provide targets the precise chemical to end if they’re existent in addition to the local area which they’re occupying. In addition, there are several views of the science and healthcare areas in regards to the quantity of danger presented by various degrees of VOCs. Lots of people don’t appear to have practically any impact to pretty tiny levels of VOCs, though other individuals are quite sensitive. We have actually built industrial and proficient screening devices with methods that anyone can use. Moldlabs VOC screening system is the greatest and simplest test it can be done to select. Instead to testing, the First transfer is constantly to carry out an assessment of your house for the natural deposits of volatile organic chemicals. A technician walks through the whole building, screening both general oxygens together with some local areas of issues.\nCertified Indoor Air Quality Tests and Laboratory Results\nIf you were to think you might be having health problems caused by VOCs, consider reducing amounts is most likely to house. If open VOC’s may lessen your personal quality of air, and be damaging to your health. VOCs aren’t hazardous in secondary volumes, however over high levels of the period, exposure can offer lots of health dangers which range from fundamental allergies to some probably increased risk of particular cancers. Our area as well as in- home laboratory screening suppliers offer you with the knowledge to boost the generation technique and obtain your option to market quickly and financially. This prediction depends on upon input from the various business to this outcome. Normally, the more expensive nature, the bigger the price tag. The few various business who carry out these providers might be helpful in getting the items, nevertheless they’ll probably can be found in regards to interpreting the outcomes. There are numerous different chemical toxins present in numerous resources. Reports of animals have actually exposed that breathing some varieties of VOCs throughout a long period of time period can amplify the risk of increasing cancer. Some folks start having signs after just one exposure to high charges of numerous harmful products.\nBreathing little degrees of VOCs for extended durations might boost some individuals’s risk of medical concerns. Breathing low quantities of VOC for extended periods can magnify the danger of medical problems. Breathing minimized expenses of VOCs for an extremely extended duration might trigger a raised danger of medical concerns. Ventilation and climate control may be utilized to reduce the experience of volatile organic chemicals in Falls Church VA.\nWe have actually got numerous means of calculating volatile natural substances, in line with the quantity of information you want. You are needed to find out about the VOC requirements for your items and make certain you comply. When you are in will require of VOC screening, contact the group to extend the result you need to secure yourself.\nYour certified evaluation business signs up the present existence of harmful VOCs in your house so you might take the methods had to produce a wholesome, more secure indoor environment. It is essential that you decide exactly which impurities occur in water before choosing the plan. Though some of it is most likely to get away while in the environment, there’ll be referred to as a little portion that’ll soak inside the surface and may accomplish water sources. Possibly modest degrees of VOCs might be incorrect for you along with your household’s health. This is the factor it is suggested to have the quality of air tested for VOC’s in your house or location of business., it is, for that reason, vital that you check for VOCs.", "domain": "chemistry", "round": 3} +{"url": "http://che.zju.edu.cn/cheen/2021/0623/c49942a2398349/page.htm", "date": "2023-06-09T12:23:23Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-23/segments/1685224656675.90/warc/CC-MAIN-20230609100535-20230609130535-00011.warc.gz", "language_score": 0.944431722164154, "token_count": 637, "dump": "CC-MAIN-2023-23", "global_id": "webtext-fineweb__CC-MAIN-2023-23__0__168217555", "lang": "en", "text": "June 23, 2021\nA amount of ZJU CBE's academic advances elected as Top 10 ZJU Academic Advances 2019-20\nOn June 7, the awarding ceremony for the Top 10 ZJU Academic Advances 2020 was held in Qiushi Lecture Hall, Zijingang Campus. At the ceremony, the ZJU Academic Committee presented the awards for the Most Outstanding Contribution 2020 and Top 10 ZJU Academic Advances 2020.\nThe Top 10 ZJU Academic Advances 2020 selection activity was started in January 2021, and 30 candidate projects were recommended. With the joint participation and support of faculties, students and the public, the Top 10 ZJU Academic Advances 2020 were selected through the evaluation of members of Academic Committee, specially invited experts and wechat praise.\nHydrophobic zeolite modification for in situ peroxide formation in methane oxidation to methanol, headed by Professor Fengshou Xiao from the College of Chemical and Biological Engineering of Zhejiang University (ZJU CBE), was elected as Top 10 ZJU Academic Advances 2020. This project creatively put forward the strategy of \"molecular fence\" to design catalyst. The experimental results show that the new catalyst can efficiently convert methane to methanol in situ at low temperature, breaking through the existing conversion limit, with conversion rate of 17.3% and methanol selectivity of 92%.\nResearch and development of active permeable and highly effective anti-tumor nanodrugs, headed by Professor Youqing Shen from ZJU CBE, was elected as Top 10 ZJU Academic Advances 2019. This project proposed a new mechanism of active penetration of nanodrugs in tumor tissues for the first time. On this basis, a series of highly effective nanodrugs were designed and synthesized.\nTopological heterogeneous polymer network, headed by Professor Tao Xie from ZJU CBE, was nominated for the Top 10 ZJU Academic Advances 2020. A new concept of topological heterogeneous polymer network is proposed. The network structure of the material is driven by entropy, and controlled isomerization occurs through dynamic covalent bond exchange, so as to realize the continuous programming control of physical and chemical properties such as crystallization of polymer materials.\nScience and technology is the primary productive force. “It’s been 9 years since the establishment of the Award for the Top 10 ZJU Academic Advances in 2013,” said Prof. Ze Zhang, chair of Zhejiang University Academic Committee. The purpose of the activity is to take stock of the achievements made by scholars of Zhejiang University in the fields of academic frontier, scientific and technological innovation and social development. ZJU CBE have won the awards for many times, which is of great significance to encourage ZJU CBE's researchers to study and serve the people.\nTo learn more about this event, please go to https://www.zju.edu.cn/english/2021/0611/c19573a2386400/page.htm.", "domain": "chemistry", "round": 3} +{"url": "https://oak.kribb.re.kr/handle/201005/10323", "date": "2022-12-07T14:33:29Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-49/segments/1669446711162.52/warc/CC-MAIN-20221207121241-20221207151241-00705.warc.gz", "language_score": 0.8294799327850342, "token_count": 677, "dump": "CC-MAIN-2022-49", "global_id": "webtext-fineweb__CC-MAIN-2022-49__0__110447677", "lang": "en", "text": "A rapid, simple method for the genetic discrimination of intact Arabidopsis thaliana mutant seeds using metabolic profiling by direct analysis in real-time mass spectrometry\nCited 17 time in\n- A rapid, simple method for the genetic discrimination of intact Arabidopsis thaliana mutant seeds using metabolic profiling by direct analysis in real-time mass spectrometry\n- Suk Weon Kim; H J Kim; Jong Hyun Kim; Y K Kwon; M S Ahn; Y P Jang; Jang Ryol Liu\n- Bibliographic Citation\n- Plant Methods, vol. 7, pp. 14-14\n- Publication Year\n- Background: Efficient high throughput screening systems of useful mutants are prerequisite for study of plant functional genomics and lots of application fields. Advance in such screening tools, thanks to the development of analytic instruments. Direct analysis in real-time (DART)-mass spectrometry (MS) by ionization of complex materials at atmospheric pressure is a rapid, simple, high-resolution analytical technique. Here we describe a rapid, simple method for the genetic discrimination of intact Arabidopsis thaliana mutant seeds using metabolic profiling by DART-MS.Results: To determine whether this DART-MS combined by multivariate analysis can perform genetic discrimination based on global metabolic profiling, intact Arabidopsis thaliana mutant seeds were subjected to DART-MS without any sample preparation. Partial least squares-discriminant analysis (PLS-DA) of DART-MS spectral data from intact seeds classified 14 different lines of seeds into two distinct groups: Columbia (Col-0) and Landsberg erecta (Ler) ecotype backgrounds. A hierarchical dendrogram based on partial least squares-discriminant analysis (PLS-DA) subdivided the Col-0 ecotype into two groups: mutant lines harboring defects in the phenylpropanoid biosynthetic pathway and mutants without these defects. These results indicated that metabolic profiling with DART-MS could discriminate intact Arabidopsis seeds at least ecotype level and metabolic pathway level within same ecotype.Conclusion: The described DART-MS combined by multivariate analysis allows for rapid screening and metabolic characterization of lots of Arabidopsis mutant seeds without complex metabolic preparation steps. Moreover, potential novel metabolic markers can be detected and used to clarify the genetic relationship between Arabidopsis cultivars. Furthermore this technique can be applied to predict the novel gene function of metabolic mutants regardless of morphological phenotypes.\n- Arabidopsis thalianaDirect analysis in real-time mass spectrometry (DART-MS)Partial least squares-discriminant analysis (PLS-DA)Seed\n- Appears in Collections:\n- Jeonbuk Branch Institute > Biological Resource Center > 1. Journal Articles\n- Files in This Item:\nItems in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.", "domain": "chemistry", "round": 3} +{"url": "http://www.mdpi.com/1422-0067/16/6/13781", "date": "2018-02-23T21:03:55Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-09/segments/1518891814833.62/warc/CC-MAIN-20180223194145-20180223214145-00115.warc.gz", "language_score": 0.8633822798728943, "token_count": 656, "dump": "CC-MAIN-2018-09", "global_id": "webtext-fineweb__CC-MAIN-2018-09__0__146079588", "lang": "en", "text": "Transcriptional Profiling of Hydrogen Production Metabolism of Rhodobacter capsulatus under Temperature Stress by Microarray Analysis\nAbstractBiohydrogen is a clean and renewable form of hydrogen, which can be produced by photosynthetic bacteria in outdoor large-scale photobioreactors using sunlight. In this study, the transcriptional response of Rhodobacter capsulatus to cold (4 °C) and heat (42 °C) stress was studied using microarrays. Bacteria were grown in 30/2 acetate/glutamate medium at 30 °C for 48 h under continuous illumination. Then, cold and heat stresses were applied for two and six hours. Growth and hydrogen production were impaired under both stress conditions. Microarray chips for R. capsulatus were custom designed by Affymetrix (GeneChip®. TR_RCH2a520699F). The numbers of significantly changed genes were 328 and 293 out of 3685 genes under cold and heat stress, respectively. Our results indicate that temperature stress greatly affects the hydrogen production metabolisms of R. capsulatus. Specifically, the expression of genes that participate in nitrogen metabolism, photosynthesis and the electron transport system were induced by cold stress, while decreased by heat stress. Heat stress also resulted in down regulation of genes related to cell envelope, transporter and binding proteins. Transcriptome analysis and physiological results were consistent with each other. The results presented here may aid clarification of the genetic mechanisms for hydrogen production in purple non-sulfur (PNS) bacteria under temperature stress. View Full-Text\nScifeed alert for new publicationsNever miss any articles matching your research from any publisher\n- Get alerts for new papers matching your research\n- Find out the new papers from selected authors\n- Updated daily for 49'000+ journals and 6000+ publishers\n- Define your Scifeed now\nGürgan, M.; Erkal, N.A.; Özgür, E.; Gündüz, U.; Eroglu, I.; Yücel, M. Transcriptional Profiling of Hydrogen Production Metabolism of Rhodobacter capsulatus under Temperature Stress by Microarray Analysis. Int. J. Mol. Sci. 2015, 16, 13781-13797.\nGürgan M, Erkal NA, Özgür E, Gündüz U, Eroglu I, Yücel M. Transcriptional Profiling of Hydrogen Production Metabolism of Rhodobacter capsulatus under Temperature Stress by Microarray Analysis. International Journal of Molecular Sciences. 2015; 16(6):13781-13797.Chicago/Turabian Style\nGürgan, Muazzez; Erkal, Nilüfer A.; Özgür, Ebru; Gündüz, Ufuk; Eroglu, Inci; Yücel, Meral. 2015. \"Transcriptional Profiling of Hydrogen Production Metabolism of Rhodobacter capsulatus under Temperature Stress by Microarray Analysis.\" Int. J. Mol. Sci. 16, no. 6: 13781-13797.", "domain": "chemistry", "round": 3} +{"url": "https://lordhomie.com/does-acetone-stain-clothes/", "date": "2024-02-22T16:43:05Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707947473824.13/warc/CC-MAIN-20240222161802-20240222191802-00860.warc.gz", "language_score": 0.9232362508773804, "token_count": 2293, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__101566910", "lang": "en", "text": "- Acetone can stain clothes: Acetone, a common solvent, has the potential to cause stains on certain fabrics. Understanding how acetone interacts with different materials is important to prevent and effectively remove stains.\n- Effects of acetone on different fabrics: Acetone can cause color fading, discoloration, and damage to fabrics such as silk, wool, rayon, and acetate. It is advisable to avoid contact between acetone and these delicate materials.\n- Removing acetone stains from clothes: Prompt action is key when dealing with acetone stains. Blotting excess acetone, pre-treating with appropriate stain removers, and washing the garment with care can help eliminate the stain. Professional cleaning may be required for delicate fabrics.\nCan Acetone Stain Your Clothes? Here’s What You Need to Know\nAcetone is a commonly used solvent, but can it leave stains on your clothing? Yes, it can. When acetone comes into contact with certain fabrics, it has the potential to cause discoloration or even dissolve the fibers. It is important to be cautious when using acetone near your clothes, especially if they are made of delicate or sensitive materials.\nThe staining effect of acetone on clothes can vary depending on factors such as the type of fabric and the concentration of acetone. Stronger concentrations of acetone are more likely to cause stains, particularly on lighter-colored fabrics. Additionally, acetone is known to have a stronger effect on natural fibers, such as cotton or wool, compared to synthetic materials.\nTo prevent staining, it is best to avoid getting acetone on your clothes in the first place much like avoiding the use of other substances that could discolor your clothes such as hydrogen peroxide. If you are working with acetone, consider wearing protective gloves or an apron to minimize contact with your clothing. In case of accidental spills or splashes, it is important to act quickly. Blot the affected area gently with a clean cloth or paper towel to remove as much acetone as possible. Avoid rubbing or scrubbing, as this can spread the stain further.\nIn a similar incident, a woman was applying nail polish remover containing acetone when she accidentally spilled some on her favorite blouse. She immediately acted by blotting the stain with a paper towel and then rinsing the area with cold water. Although the stain did not completely disappear, it faded significantly, and she was able to salvage her blouse by using a stain remover specifically designed for delicate fabrics.\nKnowing how acetone can potentially stain clothes is essential to properly handle it. By taking preventive measures and acting swiftly in the event of spills, you can minimize the risk of permanent staining and preserve the quality of your clothing.\nWhat is Acetone?\nAcetone, a colorless liquid, is a common organic solvent widely used in various industries and household products. It is highly flammable and volatile, possessing a distinct sweet smell. Acetone is known for its excellent solvent properties, making it effective in dissolving substances like resin, glue, and paint.\nAdditionally, it is widely used in nail polish removers and as a cleaning agent. Acetone evaporates quickly, leaving behind no residue, which makes it suitable for removing stains from clothes. However, it is important to note that acetone can also dissolve certain fabrics, such as acetate and rayon, leading to possible discoloration or damage.\nTo prevent staining, it is recommended to spot-test a small, inconspicuous area before using acetone on clothes. Additionally, promptly washing the fabric with mild detergent after using acetone can minimize the risk of stains.\nThe Effects of Acetone on Different Fabrics\nThe impact of acetone on various fabric types varies significantly. Understanding how this solvent affects different fabrics is crucial to prevent potential damage. To provide further insight, I created a table summarizing the effects of acetone on various fabrics:\n|Effect of Acetone\n|Acetone can dissolve or weaken cotton fibers, causing damage such as holes or tears. However, the damage may not always be severe or irreversible.\n|Acetone can dissolve or weaken wool fibers, causing damage such as holes or tears.\n|Acetone can dissolve or weaken silk fibers, causing damage such as holes or tears.\n|Polyester is generally resistant to acetone, but prolonged exposure can cause discoloration or fading.\n|Nylon is generally resistant to acetone, but prolonged exposure can cause discoloration or fading.\n|Acetone can dissolve or weaken rayon fibers, causing damage such as holes or tears.\n|Acetone can dissolve or weaken acrylic fibers, causing damage such as holes or tears.\n|Spandex is generally resistant to acetone, but prolonged exposure can cause discoloration or fading.\nRemoving Acetone Stains From Clothes\nTo effectively remove acetone stains from clothes, follow these simple steps, similar to how one would remove Vaseline stains.\n- Blot the stain: Using a clean cloth or paper towel, gently blot the stained area to remove any excess acetone. Avoid rubbing the stain, as it may spread and further penetrate the fabric.\n- Pre-treat the stain: Apply a small amount of stain remover or liquid laundry detergent directly to the affected area. Gently rub the product into the stain using your fingertips or a soft brush.\n- Let it soak: Allow the stain remover or detergent to soak into the fabric for at least 10 minutes. This will help to break down and loosen the acetone residue.\n- Rinse with cold water: Rinse the garment under cold running water to flush out the loosened stain and any remaining residue. Water temperature is important, as hot water can set the stain and make it more difficult to remove.\n- Launder as usual: Place the garment in the washing machine and launder it according to the care label instructions. Use a regular laundry detergent and choose the appropriate wash cycle and water temperature based on the fabric type.\n- Check before drying: Before machine or air drying, check the stain. If any traces of the acetone stain remain, repeat the steps above or consider using a stronger stain remover specifically designed for the fabric type.\nFor optimal stain removal, it’s important to act quickly. The longer the acetone sits on the fabric, the deeper it can penetrate and set into the fibers. Additionally, avoid using hot water or high heat during laundering, as it can also set the stain.\nBy following these steps, you can effectively remove acetone stains from clothes and restore their appearance. Remember to always check the care label instructions and test any stain removal products on a small, inconspicuous area of the garment before applying them to the stain.\nAcetone does not leave stains on clothes. It is a chemical solvent that evaporates quickly without leaving any residue. Therefore, there is no need to worry about acetone staining your clothes. However, if you have issues with other types of stains, such as needing to know how to get Neosporin out of clothes, there are resources available.\nTo ensure the best results, it is recommended to use acetone in a well-ventilated area and to wear old clothes that you wouldn’t mind getting stained, just like you would when dealing with substances such as hydraulic fluid. Using acetone to remove stains or for other purposes should be done with caution and following the instructions provided.\nSome Facts About Does Acetone Stain Clothes:\n- ✅ Acetone evaporates quickly, making it unlikely to stain clothes. (Source: Team Research)\n- ✅ Acetone is suitable for delicate materials and will not cause staining on most fabrics. (Source: Team Research)\n- ✅ Acetone can dissolve plastic and rubber, making it unsuitable for clothes made with these materials. (Source: Team Research)\n- ✅ Natural fibers like wool, silk, and satin may not take well to acetone and may be damaged. (Source: Team Research)\n- ✅ If acetone stains clothes, it can be removed by blotting, treating with a soap and water mixture, and laundering as usual. (Source: Team Research)\nDoes acetone stain clothes?\nNo, acetone does not stain clothes as it evaporates quickly and is suitable for delicate materials.\nWhat fabrics should be avoided when using acetone?\nYou should avoid using acetone on clothes made with plastic or rubber fabrics, as acetone can break through these materials.\nCan acetone damage natural fibers?\nAcetone may damage delicate natural fibers such as wool, silk, and satin. It is best to test a small area of your clothing before using acetone to avoid any discoloration or further staining.\nHow can acetone stains be removed from clothes?\nTo remove acetone stains from clothes, you can follow these steps: 1. Blot the stain with a clean cloth or cotton pad. 2. Remove any solids with a spatula or spoon. 3. Mix a quarter cup of liquid soap with one cup of water. 4. Dab the mixture gently onto the stain, working from the outside in. 5. Continue until the stain is gone and use a clean cloth to dab the area dry. 6. Launder as usual and fully dry the clothes.\nWhat can be done if the above method does not remove acetone stains?\nIf the above method does not remove acetone stains, you can try using a commercial stain remover or a product specifically designed to remove acetone stains from clothes.\nCan hairspray be used to remove acetone stains from clothes?\nYes, hairspray can be an effective stain remover for acetone stains. Here’s how to use it: 1. Remove any excess lip gloss with a knife or spatula. 2. Spray hairspray directly onto the stain and let it soak for 10 to 15 minutes. 3. Soak a cloth or cotton pad in a bowl. 4. Blot the stain, moving from the outside in. 5. Wash the clothing as normal and allow it to dry.\nFor a deeper understanding of how different substances interact with your clothes, consider having a look at these articles:\n- How to Clean Up Spilled Laundry Detergent: Gain insight into the right way to clean up detergent spills, helping you avoid unwanted stains on clothes or surfaces.\n- Does Chalk Come Out of Clothes?: Discover if chalk stains are removable from clothes, and if so, what techniques you can use to successfully get rid of them.\n- How to Wash a Polyester Blanket: Understand the best practices for cleaning polyester blankets to maintain their quality and longevity.\n- How to Get Burrs Out of Clothes: Learn how to remove burrs from your clothes safely without causing damage.\n- How to Get Fiberglass Out of Clothes: Find out how to eliminate fiberglass from your clothing to prevent skin irritation.", "domain": "chemistry", "round": 3} +{"url": "https://jrmbs.scu.ac.ir/article_15330.html", "date": "2022-09-25T10:46:59Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-40/segments/1664030334528.24/warc/CC-MAIN-20220925101046-20220925131046-00033.warc.gz", "language_score": 0.6517501473426819, "token_count": 1744, "dump": "CC-MAIN-2022-40", "global_id": "webtext-fineweb__CC-MAIN-2022-40__0__52229702", "lang": "en", "text": "F. Guinea, M.I. Katsnelson, A.K. Geim, Energy gaps and a zero-field quantum Hall effect in graphene by strain engineering, Nature Physics 6 (2009) 30-33.\n Y. Fujimoto, S. Saito, Hydrogen adsorption and anomalous electronic properties of nitrogen-doped graphene, Journal of Applied Physics 115 (2014) 153701-153706.\n S.Y. Zhou, G.H. Gweon, A.V. Fedorov, P.N. First, W.A. de Heer, D.H. Lee, F. Guinea, A.H. Castro Neto, A. Lanzara, Substrate-induced bandgap opening in epitaxial graphene, Nature Materials 6 (2007) 770-775.\n Y.-W. Son, M.L. Cohen, S.G. Louie, Energy Gaps in Graphene Nanoribbons, Physical Review Letters 97 (2006) 216803-2168037.\n V.M. Pereira, A.H. Castro Neto, N.M.R. Peres, Tight-binding approach to uniaxial strain in graphene, Physical Review B 80 (2009) 045401-045409.\n F. Xia, D.B. Farmer, Y.-m. Lin, P. Avouris, Graphene Field-Effect Transistors with High On/Off Current Ratio and Large Transport Band Gap at Room Temperature, Nano Letters 10 (2010) 715-718.\n Y. Zhang, T.-T. Tang, C. Girit, Z. Hao, M.C. Martin, A. Zettl, M.F. Crommie, Y.R. Shen, F. Wang, Direct observation of a widely tunable bandgap in bilayer graphene, Nature 459 (2009) 820-823.\n M. Topsakal, E. Aktürk, S. Ciraci, First-principles study of two- and one-dimensional honeycomb structures of boron nitride, Physical Review B 79 (2009) 115442-115453.\n L.H. Li, J. Cervenka, K. Watanabe, T. Taniguchi and Y. Chen, Strong Oxidation Resistance of Atomically Thin Boron Nitride Nanosheets, ACS Nano 8 (2014) 1457-1462.\n Q. Cai, D. Scullion, W. Gan, A. Falin, S. Zhang, K. Watanabe, T. Taniguchi, Y. Chen, E.J.G. Santos, L.H. Li, High thermal conductivity of high-quality monolayer boron nitride and its thermal expansion, Science Advances 5 (2019) 129-137.\n L. Sponza, H. Amara, C. Attaccalite, S. Latil, T. Galvani, F. Paleari, L. Wirtz and F. Ducastelle, Direct and indirect excitons in boron nitride polymorphs: A story of atomic configuration and electronic correlation, Physical Review B 98 (2018) 125206-125223.\n J. Kang, L. Zhang, S.H. Wei, A Unified Understanding of the Thickness-Dependent Bandgap Transition in Hexagonal Two-Dimensional Semiconductors, The Journal of Physical Chemistry Letters 7 (2016) 597-602.\n L. Wang, Y. Pu, A.K. Soh, Y. Shi and S. Liu, Layers dependent dielectric properties of two dimensional hexagonal boron nitridenanosheets, AIP Advances 6 (2016) 125126-125132.\n K. Zhang, Y. Feng, F. Wang, Z. Yang and J. Wang, Two dimensional hexagonal boron nitride (2D-hBN): synthesis, properties and applications, Journal of Materials Chemistry C 5 (2017) 11992-12022.\n S.-M. Choi, S.-H. Jhi, Y.-W. Son, Effects of strain on electronic properties of graphene, Physical Review B 81 (2010) 081407-081411.\n D. Moldovan, F.M. Peeters, Strain engineering of the electronic properties of bilayer graphene quantum dots, physica status solidi (RRL) – Rapid Research Letters 10 (2016) 39-45.\n X. Zhong, Y.K. Yap, R. Pandey and S.P. Karna, First-principles study of strain-induced modulation of energy gaps of graphene/BN and BN bilayers, Physical Review B 83 (2011) 193403-193407.\n Y. Fujimoto, S. Saito, Effects of strain on carbon donors and acceptors in hexagonal boron nitride monolayers, Physical Review B 93 (2016) 045402-045409.\n T. Han, Y. Luo and C. Wang, Effects of temperature and strain rate on the mechanical properties of hexagonal boron nitride nanosheets, Journal of Physics D: Applied Physics 47 (2013) 025303-025311.\n Y. Fujimoto, T. Koretsune and S. Saito, Electronic structures of hexagonal boron-nitride monolayer: strain-induced effects, Journal of the Ceramic Society of Japan, 122 (2014) 346-348.\n P. Blaha, K. Schwarz, G. Madsen, D. Kvasnicka, J. Luitz, WIEN2k, An Augmented Plane Wave Plus Local Orbitals Program for Calculating Crystal Properties (Vienna University of Technology, Austria, 2001).\n J.P. Perdew, A. Zunger, Self-interaction correction to density-functional approximations for many-electron systems, Physical Review B 23 (1981) 5048-5079.\n W.-Q. Han, L. Wu, Y. Zhu, K. Watanabe, T. Taniguchi, Structure of chemically derived mono- and few-atomic- layer boron nitride sheets, Applied Physics Letters 93 (2008) 223103-223106.\n Z. Yang, J. Ni, Modulation of electronic properties of hexagonal boron nitride bilayers by an electric field: A first principles study, Journal of Applied Physics 107 (2010) 104301-104305.\n G.-Y. Guo, Systematic ab initio study of the optical properties of BN nanotubes, Physical Review B 71 (2005) 165402-165414.\n Y. Fujimoto, S. Saito, Band engineering and relative stabilities of hexagonal boron nitride bilayers under biaxial strain, Physical Review B 94 (2016) 245427-245435.\n R. Abt, C. Ambrosch-Draxl, P. Knoll, Optical response of high temperature superconductors by full potential LAPW band structure calculations, Physica B: Condensed Matter 194-196 (1994) 1451-1452.\n C.F. Klingshirn, \"Semiconductor Optics\", Springer (2006).", "domain": "chemistry", "round": 3} +{"url": "https://cochranetechservices.com/training/courses/59/", "date": "2018-06-18T21:27:14Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-26/segments/1529267861163.5/warc/CC-MAIN-20180618203134-20180618223134-00288.warc.gz", "language_score": 0.8115194439888, "token_count": 256, "dump": "CC-MAIN-2018-26", "global_id": "webtext-fineweb__CC-MAIN-2018-26__0__88715174", "lang": "en", "text": "Flame Safeguard/Combustion Theory\nThis class consists of two evening sessions covering applications and troubleshooting. Topics covered include: Flame Sensors, Primary Controls and Programming Controls.\n- Flame sensing flame rod, thermocouple, thermopile, UV and IR scanners, self check and intelligent scanners from Fireye and Honeywell\n- Primary no purge and purge flame safeguard controls Honeywell and Fireye (Models Fireye M series, Micro M, Honeywell RM7890 and RM7895 controls)\n- Programming flame safeguard controls including: valve closure, low and high fire proving (Models Fireye E110 Series, Honeywell RM7840 series)\n- New Honeywell valve proving systems (VPS)\n- New Fireye Burner Logix flame safeguard control\nThis class is geared towards service technicians who test and tune burners for combustion efficiency. Topics covered include: Theory of Combustion, Tuning Fuel Air Ratio, Testing and Design.\nGeneral Combustion theory including chemical composition\nCO2 and carbon monoxide (CO) creation and levels\nNitrogen Oxides ( NOX) and Sulfur Dioxide ( SO2 ) formation\nDraft and burner design\nCombustion analyzer operation and principles", "domain": "chemistry", "round": 3} +{"url": "https://ir.lib.uwo.ca/mnipub/395/", "date": "2023-05-31T23:38:43Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-23/segments/1685224647459.8/warc/CC-MAIN-20230531214247-20230601004247-00360.warc.gz", "language_score": 0.8629055023193359, "token_count": 421, "dump": "CC-MAIN-2023-23", "global_id": "webtext-fineweb__CC-MAIN-2023-23__0__139331857", "lang": "en", "text": "Microbiology & Immunology Publications\nQuantitation of microbial cell surface heterogeneity by microelectrophoresis and electron microscopy - Application to lactobacilli after serial passaging\nJournal of Colloid And Interface Science\nURL with Digital Object Identifier\nThe aim of this study was to determine the physicochemical surface characteristics of seven lactobacillus strains, including L. acidophilus RC14, L. casei subsp. rhamnosus RC15 and GR1, L. acidophilus T13, L. casei subsp. rhamnosus ATCC7469, L. fermenturn B54, and L. casei #36. Surface characteristics investigated comprised hydrophobicity, zeta potentials, molecular composition, elemental surface composition, and surface morphology. These characteristics were determined by water contact angle measurements, microelectrophoresis, Fourier transform infrared spectroscopy (FTIR), X-ray photoelectron spectroscopy (XPS), and transmission electron microscopy on stained sectioned cells, respectively. Differences between strains with respect to water contact angles, ranging between 19° and 105°, and isoelectric points, varying from 1.8 to 3.8, could be related with compositional data obtained by XPS and FTIR. These relations indicated that the presence of (glyco-)proteinaceous material at the cell surface results in a higher hydrophobicity, whereas a hydrophilic surface was associated with the presence of polysaccharides. It is argued on the basis of these relations that XPS and FTIR (although the latter is not generally considered a surface-sensitive technique) both yield physiologically relevant information on the cell surfaces, despite the fact that these techniques require freeze-drying. © 1993 by Academic Press, Inc.", "domain": "chemistry", "round": 3} +{"url": "https://researchportal.hw.ac.uk/en/publications/self-assembly-of-snare-fusion-proteins-into-star-shaped-oligomers", "date": "2024-04-18T17:39:30Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712296817222.1/warc/CC-MAIN-20240418160034-20240418190034-00254.warc.gz", "language_score": 0.8993335366249084, "token_count": 329, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__74902263", "lang": "en", "text": "Three evolutionarily conserved proteins known as SNAREs (soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptors) mediate exocytosis from single cell eukaryotes to neurons. Among neuronal SNAREs, syntaxin and SNAP-25 (synaptosome-associated protein of 25 kDa) reside on the plasma membrane, whereas synaptobrevin resides on synaptic vesicles prior to fusion. The SNARE motifs of the three proteins form a helical bundle which probably drives membrane fusion. Since studies in vivo suggested an importance for multiple SNARE complexes in the fusion process, and models appeared in the literature with large numbers of SNARE bundles executing the fusion process, we analysed the quaternary structure of the full-length native SNARE complexes in detail. By employing a preparative immunoaffinity procedure we isolated all of the SNARE complexes from brain, and have shown by size-exclusion chromatography and negative stain electron microscopy that they exist as approx. 30 nm particles containing, most frequently, 3 or 4 bundles emanating from their centre. Using highly purified, individual, full-length SNAREs we demonstrated that the oligomerization of SNAREs into star-shaped particles with 3 to 4 bundles is an intrinsic property of these proteins and is not dependent on other proteins, as previously hypothesized. The average number of the SNARE bundles in the isolated fusion particles corresponds well with the co-operativity observed in calcium-triggered neuronal exocytosis.\n- Protein Structure", "domain": "chemistry", "round": 3} +{"url": "https://portlandpress.com/biochemsoctrans/article-abstract/39/1/216/85104/Gene-expression-study-of-the-flavodi-iron-proteins?redirectedFrom=PDF", "date": "2024-04-14T08:18:59Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712296816875.61/warc/CC-MAIN-20240414064633-20240414094633-00823.warc.gz", "language_score": 0.8875460624694824, "token_count": 420, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__122245211", "lang": "en", "text": "The flavodi-iron proteins, also named FDPs, are an extensive family of enzymes able to reduce dioxygen to water and/or nitric oxide to nitrous oxide. These proteins are formed by a metallo-β-lactamase-like module with a di-iron catalytic site fused to a flavodoxin-like module bearing an FMN. However, in cyanobacteria, which are oxygenic photosynthetic organisms widespread in Nature, FDPs have an extra NAD(P)H:flavin reductase-like domain as a C-terminal extension. Interestingly, cyanobacteria contain more than one gene encoding FDP-like proteins, with the genome of Synechocystis sp. PCC6803 containing four genes coding for putative FDPs. However, the function of those proteins remains unclear. In the present study, we have analysed the expression profile of these genes under oxidative and nitrosative stress conditions. The results indicate that one of the flavodi-iron genes, the so-called flv1, is induced in cells exposed to nitrosative stress. By conducting a broad analysis on the primary sequences of FDPs, we have identified that the FDPs of cyanobacteria and oxygenic photosynthetic eukaryotes may be divided into multiple types (1–12), according to the amino acid residues of the di-iron catalytic site.\nGene expression study of the flavodi-iron proteins from the cyanobacterium Synechocystis sp. PCC6803\nVera L. Gonçalves, Lígia M. Saraiva, Miguel Teixeira; Gene expression study of the flavodi-iron proteins from the cyanobacterium Synechocystis sp. PCC6803. Biochem Soc Trans 1 February 2011; 39 (1): 216–218. doi: https://doi.org/10.1042/BST0390216\nDownload citation file:", "domain": "chemistry", "round": 3} +{"url": "http://www.usbio.net/technicalSheet.php?item=C5057-03A", "date": "2015-07-08T02:21:17Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2015-27/segments/1435375635604.22/warc/CC-MAIN-20150627032715-00180-ip-10-179-60-89.ec2.internal.warc.gz", "language_score": 0.7168323993682861, "token_count": 341, "dump": "CC-MAIN-2015-27", "global_id": "webtext-fineweb__CC-MAIN-2015-27__0__109429704", "lang": "en", "text": "Suitable for use in Western Blot. Other applications not tested.\nWestern Blot: 0.2-0.5ug/ml\nOptimal dilutions to be determined by the researcher.\nMouse Brain lysate\nStorage and Stability:\nMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.\n|Synthetic peptide corresponding to C-KERARGPTKPSNLD, from the C-terminus of the protein sequence according to NP_034021.1.|\n|Purified by immunoaffinity chromatography.|\n|Supplied as a liquid in Tris saline, 0.02% sodium azide, pH7.3, 0.5% BSA.|\n|Recognizes Chat. Species Crossreactivity: rat and mouse.|\n|Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.|\n1. Contestabile A, Fila T, Bartesaghi R, Contestabile A, Ciani E. Choline acetyltransferase activity at different ages in brain of Ts65Dn mice, an animal model for Down's syndrome and related neurodegenerative diseases. J Neurochem. 2006 Apr;97(2):515-26. Epub 2006 Mar 15. PMID: 16539660 [PubMed - in process.|", "domain": "chemistry", "round": 3} +{"url": "http://med.wanfangdata.com.cn/Paper/Detail/PeriodicalPaper_PM9224563", "date": "2022-05-26T05:48:45Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-21/segments/1652662601401.72/warc/CC-MAIN-20220526035036-20220526065036-00094.warc.gz", "language_score": 0.9503110647201538, "token_count": 385, "dump": "CC-MAIN-2022-21", "global_id": "webtext-fineweb__CC-MAIN-2022-21__0__236873797", "lang": "en", "text": "Invasive properties of cadmium-resistant human fibrosarcoma HT-1080 cells.\nInvasive properties of tumor cells having acquired heavy metal resistance were investigated. We selected the cadmium-resistant (Cd-R) cells from human fibrosarcoma HT-1080 cells. Total metallothionein levels in cytosol of HT-1080 Cd-R cells were significantly higher than original lines, and were of a highly resistant potency to cytotoxicity of cisplatin, as well as heavy metals. The HT-1080 Cd-R cells showed higher invasiveness into recombinant basement membrane Matrigel. However, HT-1080 Cd-R cells were inferior in locomotion ability. Significant differences in adhesive ability to extracellular matrix proteins were not observed between HT-1080 and HT-1080 Cd-R cells. High invasiveness of HT-1080 Cd-R cells was caused by their extremely strong enzymatic activities. High level of 92kDa matrix metalloproteinase-9 (MMP-9) was recognized from the conditioned medium of HT-1080 Cd-R cells, whereas 72kDa MMP-2 was secreted equally from both cell lines. Our investigation suggests that drug resistance acquired through the mechanisms of cellular metal-tolerance may promote malignancy and tumor metastasis during cancer chemotherapy.更多", "domain": "chemistry", "round": 3} +{"url": "https://experts.umn.edu/en/publications/insulin-signalling-to-mtor-mediated-by-the-aktpkb-substrate-pras4", "date": "2020-09-19T19:56:19Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-40/segments/1600400192783.34/warc/CC-MAIN-20200919173334-20200919203334-00525.warc.gz", "language_score": 0.8884044885635376, "token_count": 309, "dump": "CC-MAIN-2020-40", "global_id": "webtext-fineweb__CC-MAIN-2020-40__0__130360478", "lang": "en", "text": "Insulin stimulates protein synthesis and cell growth by activation of the protein kinases Akt (also known as protein kinase B, PKB) and mammalian target of rapamycin (mTOR). It was reported that Akt activates mTOR by phosphorylation and inhibition of tuberous sclerosis complex 2 (TSC2). However, in recent studies the physiological requirement of Akt phosphorylation of TSC2 for mTOR activation has been questioned. Here, we identify PRAS40 (proline-rich Akt/PKB substrate 40 kDa) as a novel mTOR binding partner that mediates Akt signals to mTOR. PRAS40 binds the mTOR kinase domain and its interaction with mTOR is induced under conditions that inhibit mTOR signalling, such as nutrient or serum deprivation or mitochondrial metabolic inhibition. Binding of PRAS40 inhibits mTOR activity and suppresses constitutive activation of mTOR in cells lacking TSC2. PRAS40 silencing inactivates insulin-receptor substrate-1 (IRS-1) and Akt, and uncouples the response of mTOR to Akt signals. Furthermore, PRAS40 phosphorylation by Akt and association with 14-3-3, a cytosolic anchor protein, are crucial for insulin to stimulate mTOR. These findings identify PRAS40 as an important regulator of insulin sensitivity of the Akt-mTOR pathway and a potential target for the treatment of cancers, insulin resistance and hamartoma syndromes.", "domain": "chemistry", "round": 3} +{"url": "https://www.howcost.com/health/panasonic-bk-4mcca8ba-eneloop-aaa-new-2100-cycle-ni-mh-pre-charged-rechargeable-batteries-8-pack/", "date": "2019-09-21T17:52:06Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-39/segments/1568514574588.96/warc/CC-MAIN-20190921170434-20190921192434-00317.warc.gz", "language_score": 0.8771617412567139, "token_count": 1202, "dump": "CC-MAIN-2019-39", "global_id": "webtext-fineweb__CC-MAIN-2019-39__0__134693125", "lang": "en", "text": "Panasonic BK-4MCCA8BA Eneloop AAA New 2100 Cycle Ni-MH Pre-Charged Rechargeable Batteries, 8-Pack\n|Deal:||$16.69 (SAVE 38% Now!)|\n|as of 09/21/2019 (Details)|\nPanasonic BK-4MCCA8BA eneloop AAA New 2100 Cycle Ni-MH Pre-Charged Rechargeable Batteries eneloop 2100 Cycle Battery Cell eneloop Ni-MH “Low Self Discharge” batteries utilize Panasonic’s advanced rechargeable battery technology allowing them to be recharged up to 2100 times. eneloop battery cells deliver consistent power performance, maintain 70% of their charge for up to 5 years*, come pre-charged by solar power (at the factory) and are ready to use out of the package. These eneloop cells also have increased storage life and extreme temperature performance down to -4 degrees Fahrenheit. eneloop - The Birth of a New Technology Since 1931 Panasonic has been a leading manufacturer of battery technology. In 2005, eneloop was launched as a new type of rechargeable battery that would change the way people live, work and play. This rechargeable battery was created with a very simple idea in mind; provide a common energy source that can be reused over and over again. This “looping energy” became eneloop. Today, eneloop battery cells are recognized by millions of consumers worldwide as the industry’s premier rechargeable battery. Key Features eneloop Ni-MH 2000mAh typical /1900mAh minimum (AA) 800mAh typical / 750mAh minimum (AAA) holds up to 70% of their charge after 5 years of non-use*. It can be recharged up to 2100 times. It is pre-charged at the factory using power generated from solar energy and is ready to use right out of the package. It works in extreme temperatures down to –4°F. Batteries can be recharged when fully, or partially drained Ni-MH. These \"Low Self Discharge\" rechargeable batteries are based on IEC 61951-2(7.3.2). The battery life is based on a testing method established by IEC 61951-2(188.8.131.52). Results may vary based on conditions of use. As certified by The Green Energy Certification Center storage can be done at 20° (68F) ambient conditions (Discharge: . 2lt, E. V equals 1.0V) (varies according to conditions of use). eneloop batteries need a charger to be recharged. Panasonic Ni-MH battery chargers are recommended. Maintains 70% Charge up to 5 Years (when not in use)View larger Long Storage Life eneloop 2100 cycle rechargeable Ni-MH batteries maintain 70% of their charge for up to 5 years* when not in use. View larger What Makes eneloop so Incredible eneloop batteries utilize a highly-durable super lattice alloy which prolongs the life of this important material. Improvements to this super-lattice alloy have increased hydrogen stability resulting in reduced self-discharge and long lasting, stable voltage output. Solar Panels at the Factory Clean Energy from the Factory to Your Device eneloop’s unique \"Clean Energy Loop\" initiative is a reality. All eneloop 2100 cycle and eneloop pro batteries are pre-charged at the factory in Japan using power generated from solar energy. This process is certified twice a year by the Green Energy Certification Center. View larger Improved Conductive Surface Layer Improvements to the conductive surface layer of the active (positive) electrode material (made primarily from nickel-metal hydride) produce greater conductivity and durability. By limiting the degradation of the conductive layer, it has been possible to reduce performance degradation during repeated use and thus increase the number of times that eneloop batteries can be recharged – all without increasing the amount of negative electrode alloy used and enabling the new eneloop cells to be recharged up to 2100 times. View larger Consistently Stable Power The initial voltage level of a battery provides no indication of how long the battery will last or how much power it can deliver. Alkaline battery cells rapidly drop below 1.5V soon after they are put into use and the voltage continues to steadily decline over time. Since alkaline cells are non-rechargeable, they must be discarded and then replaced. eneloop batteries deliver best-in-class Ni-MH high capacity power and “rechargeability” combination up to 2100 times. Devices including cameras flash units and wireless game controllers can easily draw more than 1000mA of current; rapidly depleting alkaline batteries power. eneloop batteries maintain a consistently high voltage level keeping your devices operating for a long period of time. Works in Extreme Temperatures Down to -4 Degrees Fahrenheit Performance Down to -4 Degrees Fahrenheit Keep your tactical flashlights, walkie-talkie radios, battery powered lanterns, cameras and other devices powered in the winter. eneloop 2100 cycle and eneloop pro batteries deliver exceptional performance at extreme low temperatures, down to –4°F.\n- Recharge up to 2100 times\n- Maintain up to 70% of their charge after 5 years (when not it use)\n- 800mAh type, 750mAh min, Ni-MH pre-charged rechargeable battery\n- Pre-Charged at the factory using solar power and ready to use\n- No memory effect - batteries can be recharged when fully, or partially discharged\nDo you want ot get the Panasonic BK-4MCCA8BA Eneloop AAA New 2100 Cycle Ni-MH Pre-Charged Rechargeable Batteries, 8-Pack?", "domain": "chemistry", "round": 3} +{"url": "https://www.master-builders-solutions.basf.co.za/en/products/masterglenium/masterglenium-sky-923", "date": "2020-01-20T16:01:03Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-05/segments/1579250598800.30/warc/CC-MAIN-20200120135447-20200120164447-00450.warc.gz", "language_score": 0.8557633757591248, "token_count": 399, "dump": "CC-MAIN-2020-05", "global_id": "webtext-fineweb__CC-MAIN-2020-05__0__36883045", "lang": "en", "text": "MasterGlenium SKY 923 - Workability - Retaining Admixture\nMasterGlenium Sky 923 admixture is a revolutionary new technology based on significant advances in admixture chemistry.\nMasterGlenium Sky 923 admixture is used as part of an admixture system to provide customized admixture solutions for a wide range of concrete applications.\nMasterGlenium Sky 923 admixture is a workabilityretaining admixture that provides flexible degrees of slump retention without retardation.\nMasterGlenium Sky 923 admixture provides the concrete producer with the ability to immediately create the optimal admixture system for changing and fluctuating regional raw materials, environmental conditions and project requirements.\nMasterGlenium Sky 923 admixture gives the concrete producer the ability to consistently produce and deliver quality concrete mixtures.\nWhere is MasterGlenium SKY 923 applied?\n- MasterGlenium Sky 923 is recommended for use\n- Concrete with varying slump requirements\n- Concrete mixtures utilizing supplementary\n- Concrete where high flowability, increased\nstability and durability are needed\n- Ready-mixed and precast concrete\n- Production of self-consolidating concrete in\nWhat are the advantages of MasterGlenium SKY 923?\n- Workability retention without retardation\n- Flexible levels of workability retention by\n- Improved early- and late-age compressive\nBENEFITS MasterGlenium Sky 923 offers the following benefits:\n- Promotes greater consistency of concrete\nworkability at the jobsite\n- Promotes consistency in compressive\nstrengths via minimized jobsite addition of\n- Minimizes re-dosing of high-range waterreducing\nadmixture at the job site\n- Consistent air-entrainment\n- Fewer rejected loads and better customer\nsatisfaction due to consistent quality of\n- Faster truck turn-around time\n- Expanded concrete delivery range", "domain": "chemistry", "round": 3} +{"url": "https://www.petrakinc.com/products/drum-decanting/", "date": "2022-08-09T01:45:47Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882570879.37/warc/CC-MAIN-20220809003642-20220809033642-00144.warc.gz", "language_score": 0.9106245040893555, "token_count": 410, "dump": "CC-MAIN-2022-33", "global_id": "webtext-fineweb__CC-MAIN-2022-33__0__116294921", "lang": "en", "text": "A drum decanter decants and doses additive components from drums or containers. Drum decanting units (DDUs) often contain a decanting lance, a roller conveyor, a loading platform, a rinsing tank, pumps and process pipes. They can also be skid-mounted modular systems.\nPetrak Industries, Inc. drum decanting units are a mechanized, automated way to add drummed additives to your blending system. Our mechanized drum decanting supports greater safety and utilization of resources while reducing blending variation and labor costs. A Petrak drum decanter’s automation simplifies management of recipes and production while helping to prevent new waste.\nToday’s complex recipes require more specialized additives to enter into the formula. Delivered in drum containers, these special additives involve up to 20% of the recipe.\nAs the additives for different products increase, the efficient handling of drummed additives becomes integral to the blending process. Petrak Industries drum decanting makes it possible to empty even the most viscous drummed additives.\nOur drum decanting units include:\n- drum-weighing platform\n- drum emptying\n- drum cleaning\n- pipe cleaning\n- local operator station\nPetrak systems help you ensure maximum discharge of additives, including residues clinging to drums. Because our DDUs are connected to a pigging system, they pump the additives straight into the pigging line so that all additives and base oil are pigged into the blending tank. You can also manage the unit through a local control system for complete automation and dosing.\nWe are a complete design, engineering and manufacturing firm with decades of experience. Having installed units throughout the U.S. and the globe, we understand the intrinsic details of components and electronics that constitute advanced, efficient drum decanters.\nContact us at 815-483-2290 today to find out more about our customized equipment and systems for drum decanting units. A Petrak professional will be glad to speak with you.", "domain": "chemistry", "round": 3} +{"url": "https://www.auffenbergcapehyundai.com/blog/a-rookies-guide-to-radiator-fluid-antifreeze-vs-coolant/", "date": "2022-12-02T13:54:23Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-49/segments/1669446710902.80/warc/CC-MAIN-20221202114800-20221202144800-00609.warc.gz", "language_score": 0.9162850379943848, "token_count": 1458, "dump": "CC-MAIN-2022-49", "global_id": "webtext-fineweb__CC-MAIN-2022-49__0__232819271", "lang": "en", "text": "- Radiator fluid helps transfer heat away from the engine and prevents overheating.\n- Antifreeze has many benefits, including preventing engine freezing and corrosion.\n- Coolant prevents your radiator from overheating.\n- Antifreeze and coolant also help lubricate the water pump so it can continue to move the coolant efficiently.\n- Radiator fluid is typically ethylene glycol-based and needs to be replaced every two years or 30,000 miles or two years.\n- Auffenburg Hyundai of Cape Girardeau offers quality car repair and maintenance services to customers in Chaffee, MO, and the surrounding areas.\nWhen it comes to car maintenance, the radiator fluid is one of the most important things to know about. It keeps your engine cool, and it also helps to prevent freezing in cold weather. There are two broad types of radiator fluids. Antifreeze is developed to lower the freezing point of water, while coolant helps to regulate the engine temperature. Auffenburg Hyundai of Cape Girardeau will discuss the differences between antifreeze and coolant and how to choose the right type of radiator fluid for your car.\nWhen choosing a radiator fluid, it is essential to consider the climate in which you will be driving your car. If you experience cold winters in our area, you will need to use a radiator fluid that has a lower freezing point. Conversely, if you live in an area with hot summers, you will need to use a radiator fluid with a higher boiling point.\nRadiator fluid is available at most car dealerships and auto parts stores. Following the packaging instructions is essential when adding radiator fluid to your car. Overfilling the radiator can cause damage to the engine, so it is crucial to add the liquid slowly and carefully.\nIf you are unsure which fluid type is best for your car, consult a local car dealership or auto parts store professional. They will be able to help you choose the right product for your vehicle and climate.\nAntifreeze vs. Coolant\nAntifreeze is a chemical that lowers the freezing point of water. Antifreeze is used in car radiators to help prevent the engine from freezing in cold weather. Antifreeze is available in liquid and gel form, typically green or yellow in color. Coolant, on the other hand, is a mixture of water and antifreeze that helps to regulate the engine temperature. Coolant is usually red or blue in color.\nBenefits of Antifreeze Coolant\nThere are many benefits to using antifreeze and coolant in your vehicle. In addition to preventing your engine from overheating or freezing, they also help to protect the machine parts against corrosion. They can extend the life of your vehicle by keeping it clean and free of rust and other corrosive materials. They also help lubricate the water pump so it can continue to move the coolant efficiently. The water pump circulates the fluid throughout the engine. The coolant helps to keep the engine at a consistent temperature by absorbing heat and transferring it away from the engine.\nTypes of Coolant\nIt’s essential to use a compatible type of fluid in your car. Different car engines require different types of radiator fluids. Be sure to consult your car’s owner manual or a car dealership before adding any liquids to your vehicle.\nMost modern cars use an “all-in-one” radiator fluid, a mixture of water and antifreeze. This type of fluid is usually green, pink, or blue in color. You can find all-in-one radiator fluids at most auto parts stores. Here are the basic types of coolant:\n1. Ethylene Glycol\nEthylene glycol is a toxic chemical used as an antifreeze in cars and airplane cooling systems. It keeps the water from freezing in cold weather conditions. It also raises the water’s boiling point, so it doesn’t overheat as quickly. It makes the coolant an ideal solution for keeping your engine at a consistent temperature, no matter the outside temperature.\n2. Propylene Glycol\nPropylene glycol is a thick liquid that comes from plants. It has many different uses, but one of its most common applications involves being used as an ingredient in the coolant. It has a sweet smell.\nWhy Can’t I Mix Propylene Glycol and Ethylene Glycol?\nNever mix ethylene glycol and propylene glycol. They don’t mix well and are poisonous if ingested. They are quite different in terms of fluidity, toxicity, and heat transfer properties. When mixed, ethylene glycol and propylene glycol produce a hazardous by-product that must be emptied, cleaned out thoroughly, and refilled with suitable glycol fluid.\nChanging Your Radiator Fluid\nAs summer ends, now is an excellent time to think about changing your antifreeze and coolant. They help to keep your engine running at an optimal temperature, even in cold weather conditions. It is also essential to change your radiator fluid regularly to prevent corrosion and extend the life of your engine.\nMost car manufacturers recommend changing the radiator fluid every 30,000 miles or every two years. However, if you live in an area with extreme temperatures, you may need to change it more frequently. You can check your car’s owner’s manual for specific recommendations to determine when to change your radiator fluid.\nIf you find that your car’s engine is running hot or the temperature gauge on your dash is reading higher than usual, it could be a sign that you need to add more radiator fluid. Other symptoms that you might need to add radiator fluid include:\n- A sudden drop in coolant levels.\n- Leaks in the radiator or hoses.\n- Discolored (rusty) radiator fluid.\nIf you need to add more radiator fluid, use the same type of fluid already in your car. Mixing different kinds of radiator fluid can cause engine damage.\nAlso, please read our article on the signs of a failing radiator to prevent engine overheating.\nHow to Test Antifreeze Coolant Level and Strength?\nA refractometer or hydrometer test kit can measure the freezing point, boiling point, and concentration of antifreeze in the coolant. This information lets you know if your car’s cooling system is working correctly.\nNeed Car Maintenance and Repair Services in Chaffee, MO? No Problem!\nAuffenburg Hyundai of Cape Girardeau, serving Chaffee, MO, is committed to providing our customers with the best possible service. From car sales and financing to service and parts, we’ve got you covered. Our team is dedicated to making sure your experience at our car dealership is nothing short of exceptional. Schedule a service today or browse our inventory online. We know you’ll find the perfect car for your needs.\nThanks for choosing Auffenburg Hyundai of Cape Girardeau!", "domain": "chemistry", "round": 3} +{"url": "https://vtechworks.lib.vt.edu/handle/10919/36667", "date": "2018-10-16T20:56:55Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-43/segments/1539583510867.6/warc/CC-MAIN-20181016201314-20181016222814-00408.warc.gz", "language_score": 0.9203982353210449, "token_count": 416, "dump": "CC-MAIN-2018-43", "global_id": "webtext-fineweb__CC-MAIN-2018-43__0__67523643", "lang": "en", "text": "Cloning and Characterization of a Gene Involved in Lipooligosaccharide Biosynthesis in Haemophilus somnus\nHensley, Jennifer A.\nMetadataShow full item record\nRepetitive tetramers of the DNA sequence 5'-CAAT-3' are present in several loci associated with lipooligosaccharide (LOS) phase variation in Haemophilus influenzae type b (Hib). In an attempt to identify H. somnus phase-variable LOS genes, the presence of CAAT repeats within the H. somnus 738 genome was confirmed using a (CAAT)7 probe. A 3.9 kb EcoRI fragment that reacted with the probe was cloned and sequenced. Sequence analysis confirmed the presence of 31 CAAT repeats downstream of two potential start codons, and indicated that small or large proteins would be encoded depending on the number of CAAT repeats. The larger gene products showed 46% amino acid homology to Lex2b from Hib, which influences LOS phase variation in that species. In H. somnus, this gene was named lob1 (lipooligosaccharide biosynthesis gene). Sequence analysis showed that randomly selected colonies most frequently contained 33 CAAT repeats in lob1, corresponding to a 294 amino acid product. Colonies selected for negative reactivity to mAb 5F5 were significantly more likely to have different numbers of CAAT repeats in lob1 than randomly selected colonies. The presence of lob1 in trans altered the LOS profile of a non-phase variable strain of H. somnus, and caused increased levels of reactivity to polyclonal antisera made to purified LOS from strain 738. Based on the ability of this gene to alter the LOS profile of a non-phase varying strain and the correlation of changes in CAAT repeats with mAb 5F5 reactivity, lob1 appears to be involved in LOS biosynthesis and phase variation.\n- Masters Theses", "domain": "chemistry", "round": 3} +{"url": "https://www.scienceopen.com/document?vid=9771b4fe-4803-43a4-8b24-68eb788df30c", "date": "2021-05-08T07:15:31Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-21/segments/1620243988850.21/warc/CC-MAIN-20210508061546-20210508091546-00047.warc.gz", "language_score": 0.9597062468528748, "token_count": 319, "dump": "CC-MAIN-2021-21", "global_id": "webtext-fineweb__CC-MAIN-2021-21__0__216264237", "lang": "en", "text": "The use of recycled aggregate (RA) instead of natural aggregate (NA) in concrete is necessary for environmental protection and the effective utilization of resources. The addition of recycled aggregates in concrete increases shrinkage, porosity and decreases the mechanical properties compared to that of normal concrete. This study was aimed at investigating how the addition of various proportions of polypropylene and steel fiber affect the mechanical properties of recycled aggregate concrete (RAC). The natural coarse aggregates (NCAs) used in the production of normal concrete (NC) were replaced in 30% and 50% proportions by recycled coarse aggregates (RCAs) obtained from the demolished buildings. In this case, a polypropylene fiber (PF) content of 0.1% and steel fiber (SF) 1% and 2% volume fractions were used, along with hybrid fibers-a combination of the two. While the material performance of RAC compared to NC is analyzed by reviewing existing published literature, it is not evident what the use of RCAs and hybrid fibers have on the mechanical properties of concrete. The results showed that the compressive strength, flexural strength and impcat resistance of RAC were reduced as the percentage of RCAs increased. It was observed that the compressive strength was increased with the addition of 1% steel fiber in the RAC. The flexural and impact performance of steel fiber-reinforced concrete (Specimens NC and RAC) was increased as the volume fractions of steel fiber increased. The hybrid fiber reinforced concretes showed the best results in their mechanical performance of all the concrete groups.", "domain": "chemistry", "round": 3} +{"url": "http://balloons.hitsradio.us/naming-ionic-compounds-worksheet-doc/", "date": "2020-08-09T16:43:48Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-34/segments/1596439738562.5/warc/CC-MAIN-20200809162458-20200809192458-00558.warc.gz", "language_score": 0.9021690487861633, "token_count": 1819, "dump": "CC-MAIN-2020-34", "global_id": "webtext-fineweb__CC-MAIN-2020-34__0__154963017", "lang": "en", "text": "Table of Contents :\nTop Suggestions Naming Ionic Compounds Worksheet Doc :\nNaming Ionic Compounds Worksheet Docs\nNaming Ionic Compounds Worksheet Write The Name Of Each Of The Following Compounds Ca Bro 3 2 1 Al 2 O 3 2 Baf 2 3\nNaming Ionic Compounds Practice Worksheet\nSummer Review Sheet 3 Naming Compounds And Molar Masses Name Each Of The Following Chemical Compounds And List Their Molar Masses To The Nearest G Mol 1 Agno3 2 Pbso4 3 N2o3 4 Cocl2 4 H2o 5 Nh3 6 Pbr3 7 B2f6 8 Sn Co3 2 Write The Formulas Of Each Of The Following Chemical Compounds And List Their Molar Masses To The Nearest\nChem02 Ionic Compounds Worksheet Docs\nSnc 2d Ionic Compounds Names And Formulas Practice Name Instructions Refer To The Lesson To Complete The Following Sheet And Your Periodic Table 1 Provide The Ion Symbols And Charges For The Following Elements Or The Element For The Ion Element Ion Element Ion Lit\nNaming Ionic Compounds Practice Worksheet\nSolutions For The Naming Ionic Compounds Practice Worksheet 1 Ammonium Chloride 2 Iron Iii Nitrate 3 Titanium Iii Bromide 4 Copper I Phosphide 5 Tin Iv Selenide 6 Gallium Arsenide 7 Lead Iv Sulfate 8 Beryllium Bicarbonate 9 Manganese Iii Sulfite 10 Aluminum Cyanide 11 Cr Po 4 2 12 V Co 3\nNaming Ionic Compounds Practice Worksheet Mafiadoc\nNaming Ionic Compounds Practice Worksheet Name The Following Ionic Compounds 1 Nh4cl 2 Fe No3 3 3Simple Ionic Compounds Worksheet Weebly\nWrite The Chemical Formulas For Each Of The Following Simple Ionic Compounds A Potassium Fluoride I Barium Oxide B Silver Chloride J Zinc Bromide C Calcium Nitride K Aluminum Sulfide D Sodium Chloride L Boron Oxide E Aluminum Carbide M Strontium Phosphide F Beryllium Oxide N Silver Iodide G Magnesium Fluoride O Hydrogen Selenide H Zinc Sulfide P Cesium HydrideNaming Worksheet 6\nNaming Worksheet 2 Name Ionic Compounds Date Per Name Ionic Compounds That Have Polyatomic Ions A Polyatomic Ions Poly Means Many Ions Are Particles With A Positive Or Negative Charge So Polyatomic Ions Are Groups Of Many Two Or More Atoms That Have A Charge The Group As A Whole Shares The Charge The Polyatomic Ion Is Treated Just Like The Negative Nonmetals WeWriting And Naming Binary Compounds Worksheet\nWriting And Naming Binary Ionic Compounds Worksheet Write A Correct Chemical Formula For Each Of The Following Binary Compounds Cadmium Sulfide\nIonic Compound Formula Writing Worksheet\nIonic Compound Naming Chilton Honors Chemistry Ionic Compound Formula Writing Worksheet Write Chemical Formulas For The Compounds In Each Box The Names Are Found By Finding The Intersection Between The Cations And Anions Example The First Box Is The Intersection Between The Zinc Cation And The Chloride Anion So You Should Write Zncl 2 As Shown Zinc Iron Ii Iron\nCompound Names And Formulas Tutorial And Worksheet\nNaming Compounds Tutorial And Worksheet Since We Use Different Methods In Naming Binary Covalent Molecular Compounds And Ionic Compounds The First Step In Naming Or Writing The Formula Of A Compound Is To Determine Which Of The 2 Compound Classes It Belongs This Can Be Done As Follows Binary Covalent Compounds Will Contain Only Two Types Of Non Metal Elements There May Be More Than One\nNaming Ionic Compounds Worksheet Doc. The worksheet is an assortment of 4 intriguing pursuits that will enhance your kid's knowledge and abilities. The worksheets are offered in developmentally appropriate versions for kids of different ages. Adding and subtracting integers worksheets in many ranges including a number of choices for parentheses use.\nYou can begin with the uppercase cursives and after that move forward with the lowercase cursives. Handwriting for kids will also be rather simple to develop in such a fashion. If you're an adult and wish to increase your handwriting, it can be accomplished. As a result, in the event that you really wish to enhance handwriting of your kid, hurry to explore the advantages of an intelligent learning tool now!\nConsider how you wish to compose your private faith statement. Sometimes letters have to be adjusted to fit in a particular space. When a letter does not have any verticals like a capital A or V, the very first diagonal stroke is regarded as the stem. The connected and slanted letters will be quite simple to form once the many shapes re learnt well. Even something as easy as guessing the beginning letter of long words can assist your child improve his phonics abilities. Naming Ionic Compounds Worksheet Doc.\nThere isn't anything like a superb story, and nothing like being the person who started a renowned urban legend. Deciding upon the ideal approach route Cursive writing is basically joined-up handwriting. Practice reading by yourself as often as possible.\nResearch urban legends to obtain a concept of what's out there prior to making a new one. You are still not sure the radicals have the proper idea. Naturally, you won't use the majority of your ideas. If you've got an idea for a tool please inform us. That means you can begin right where you are no matter how little you might feel you've got to give. You are also quite suspicious of any revolutionary shift. In earlier times you've stated that the move of independence may be too early.\nEach lesson in handwriting should start on a fresh new page, so the little one becomes enough room to practice. Every handwriting lesson should begin with the alphabets. Handwriting learning is just one of the most important learning needs of a kid. Learning how to read isn't just challenging, but fun too.\nThe use of grids The use of grids is vital in earning your child learn to Improve handwriting. Also, bear in mind that maybe your very first try at brainstorming may not bring anything relevant, but don't stop trying. Once you are able to work, you might be surprised how much you get done. Take into consideration how you feel about yourself. Getting able to modify the tracking helps fit more letters in a little space or spread out letters if they're too tight. Perhaps you must enlist the aid of another man to encourage or help you keep focused.\nNaming Ionic Compounds Worksheet Doc. Try to remember, you always have to care for your child with amazing care, compassion and affection to be able to help him learn. You may also ask your kid's teacher for extra worksheets. Your son or daughter is not going to just learn a different sort of font but in addition learn how to write elegantly because cursive writing is quite beautiful to check out. As a result, if a kid is already suffering from ADHD his handwriting will definitely be affected. Accordingly, to be able to accomplish this, if children are taught to form different shapes in a suitable fashion, it is going to enable them to compose the letters in a really smooth and easy method. Although it can be cute every time a youngster says he runned on the playground, students want to understand how to use past tense so as to speak and write correctly. Let say, you would like to boost your son's or daughter's handwriting, it is but obvious that you want to give your son or daughter plenty of practice, as they say, practice makes perfect.\nWithout phonics skills, it's almost impossible, especially for kids, to learn how to read new words. Techniques to Handle Attention Issues It is extremely essential that should you discover your kid is inattentive to his learning especially when it has to do with reading and writing issues you must begin working on various ways and to improve it. Use a student's name in every sentence so there's a single sentence for each kid. Because he or she learns at his own rate, there is some variability in the age when a child is ready to learn to read. Teaching your kid to form the alphabets is quite a complicated practice.\nTags: #naming organic compounds worksheet#ionic compound formulas worksheet#writing ionic formulas worksheet#chemistry naming worksheets#naming hydrocarbons worksheet#naming simple ionic compounds worksheet#nomenclature worksheet and answer sheet#naming ionic compounds worksheet 1#practice worksheet key", "domain": "chemistry", "round": 3} +{"url": "https://www.apexbt.com/signaling-pathways/pi3k-akt-mtor-signaling.html", "date": "2023-02-03T06:57:07Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-06/segments/1674764500044.16/warc/CC-MAIN-20230203055519-20230203085519-00213.warc.gz", "language_score": 0.8103101849555969, "token_count": 568, "dump": "CC-MAIN-2023-06", "global_id": "webtext-fineweb__CC-MAIN-2023-06__0__196413851", "lang": "en", "text": "The PI3K/Akt/mTOR signaling pathway is a key regulator in growth, survival, cell cycle proliferation, protein synthesis and glucose metabolism. Growth factors, hormones, and cytokines can activate this pathway by binding their cognate receptor tyrosine kinase (RTK), cytokine receptor, or GPCR, resulting in the activation of lipid kinase PI3K which produces PIP3 at the plasma membrane.\nThe binding of PIP3 translocates Akt to cell membranes, enables Akt activation through phosphorylation at Thr308 mediated by phosphoinositide dependent kinase 1 (PDK1). In addition, Akt is phosphorylated at Ser473 by the mTOR-rictor complex, mTORC2. PTEN is a negative regulator of Akt signaling that reverses the function of PI3K by removing 3’-phosphate groups. Akt activity is also negatively regulated by the phosphatases PP2A and PHLPP. Akt propagates its signal to affect DNA transcription, cell cycle and apoptosis. Akt can activate mTOR directly by phosphorylation or indirectly, by phosphorylation and inactivation of mTOR inhibitor TSC2 and PRAS40. Together these mechanisms stimulate cell growth and G1 cell cycle progression through signaling via p70 S6 Kinase and inhibition of 4E-BP1. Defects in PI3K/AKT/mTOR signaling are implicated in cancer, diabetes and cardiovascular disease etc.\nItems 1-10 of 191\n- B5246 740 Y-P5 CitationTarget: PI3KSummary: PI 3-kinase activator,cell permeable\n- B4660 PI-3065Target: PI3KSummary: P110δkinase inhibitor\n- B1374 WZ4003Target: NUAK1|NUAK2Summary: NUAK1/2 inhibitor, potent and selective\n- C5867 Akt Inhibitor IV\n- A8764 Rapalink-1Target: mTORSummary: third-generation mTOR inhibitor\n- B7826 GDC-0084Summary: PI3K and mTOR inhibitor, brain-permeable\n- C5645 3-Guanidinopropionic AcidSummary: AMPK stimulator\n- C5216 NG,NG-dimethyl-L-Arginine (hydrochloride)1 CitationSummary: endogenous nitric oxide synthase inhibitor\n- B7875 Adenosine 5-monophosphateSummary: 5'-AMP-activated protein kinase\n- C5053 KP372-1Summary: specific Akt inhibitor", "domain": "chemistry", "round": 3} +{"url": "http://www.ou.edu/catalysis/catalysis.htm", "date": "2018-12-14T14:57:33Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-51/segments/1544376825916.52/warc/CC-MAIN-20181214140721-20181214162221-00629.warc.gz", "language_score": 0.7187942862510681, "token_count": 350, "dump": "CC-MAIN-2018-51", "global_id": "webtext-fineweb__CC-MAIN-2018-51__0__168706081", "lang": "en", "text": "During the last years the heterogenous catalysis group have worked in different areas such as:improving diesel fuel; aromatization of alkenes (n-hexane and n-octane); simultaneous hydrogenation of multiring aromatic compounds over NiMo catalysts; gas-phase kinetic studies of tetralin hydrogenation on Pt/Alumina; competitive hydrogenation of poly-aromatic hydrocarbons on sulfur-resistant bimetallic Pt-Pd catalysts and many other projects.\nResearch associates, visiting scholars and M.S. and Ph.D students have contributed to the heterogenous catalysis research and as a result over 40 papers have been published.\nFor more details, go to the journal papers page.\nStudents and collaborators (1995-2009):\nResearch associates: Walter E. Alvarez, Haiyang Liu, Cristina Padro, Adriana Pisanu, Armando Borgna, Manuel Nunez Isaza, Ricardo Rey Soares, Fabio Noronha, Francisco Pompeo.\nVisiting scholars: Siraprapha Dokjampa, Supak T., Pisan Chungchamroemkit.\nM.S and Ph.D students: Mario Coelho, Christopher Loughran, Jeff Smith, Ahmed Ali, Susan M. Stagg, Srinivas Chintapalli, Firoz Ghadiali, Gary Jacobs, Ya-Huei Chin, Lorena Serventi, Zoran Juric, Boonyarach Kitiyanan, Siriporn Jongpatiwu, Li Zhongru, Malee Santikunaporn, Roberto Santana, Nataphan Chareonchaisakul.", "domain": "chemistry", "round": 3} +{"url": "https://www.labelmaster.com/shop/labels/ghs-hazcom-and-nfpa-labels/ghs-labels/ghs-pictogram-labels/ghs-flame-pictogram-labels/product-category=labels-ghs-hazcom-and-nfpa-labels-ghs-labels/ghs-label-flame-2-x-2-vinyl-sheet-of-4-h118823?returnurl=%2Fshop%2Flabels%2Fghs-hazcom-and-nfpa-labels%2Fghs-labels%2Fghs-pictogram-labels%2Fghs-flame-pictogram-labels%2Fproduct-category%3Dlabels-ghs-hazcom-and-nfpa-labels-ghs-labels%2F", "date": "2023-01-27T01:54:44Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-06/segments/1674764494852.95/warc/CC-MAIN-20230127001911-20230127031911-00374.warc.gz", "language_score": 0.8001126050949097, "token_count": 331, "dump": "CC-MAIN-2023-06", "global_id": "webtext-fineweb__CC-MAIN-2023-06__0__33103313", "lang": "en", "text": "Properly label your hazardous chemicals with Labelmaster's GHS Flame Pictogram Labels. The UN Globally Harmonized System (GHS) of classification and labeling of chemicals is used to: enhance the protection of human health and the environment by providing an international system for hazard communication; provide a recognized framework for countries without a system; reduce the need for testing and evaluation of chemicals; and facilitate international trade in chemicals whose hazards have been properly assessed and identified on an international basis. These labels use the standard GHS pictograms to depict the recommended measures that should be taken to minimize or prevent adverse effects resulting from exposure to a hazardous product. They also instruct users how to minimize improper storage or handling of a hazardous product. The Flame pictogram symbol is printed on red framed, 2 x 2-in., vinyl labels. These labels come four to a sheet and are sold individually.\n|Format Unit Of Measure||4|\n|Suggested Usage||To Define And Identify Hazards Associated With Chemicals|\n|Country Of Origin||US|\n|Harmonized Tariff Code||3919905060|", "domain": "chemistry", "round": 3} +{"url": "https://nzsi.co.nz/products/methyl-b-complex-liposomal-quicksilver-scientific", "date": "2022-05-24T05:57:54Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-21/segments/1652662564830.55/warc/CC-MAIN-20220524045003-20220524075003-00113.warc.gz", "language_score": 0.8600313663482666, "token_count": 319, "dump": "CC-MAIN-2022-21", "global_id": "webtext-fineweb__CC-MAIN-2022-21__0__155359306", "lang": "en", "text": "METHYL B-COMPLEX - LIPOSOMAL 50ml in New Zealand\nLiposomal Methyl B-Complex delivers 12.5mg B1, 7.5mg B2, 10mg B3, 25mg B5, 7.5mg B6, 500mcg B7, 500mcg B9, 500mcg B12, 25mg Trimethylglycine, and 50mg milk thistle extract per serve. Supports energy metabolism, detoxification, immunity, balanced mood, cognitive function and gut health.\nBecause age, low stomach acid, and genetic variation can impair absorption of B complex vitamins, this liposomal formulation is designed to deliver B12 faster & more efficiently.\nEach 1 mL delivers B1 (Thiamin), B2 (Riboflavin), B3 (Niacin), B5 (Pantothenic Acid), B6, B7 (Biotin), B9 (Folate), and B12 (Methylcobalamin).\nThis formula also includes Trimethylglycine, which serves a vital role in methylation, and Milk Thistle to support the liver.*\nThe difference is clear: this product’s clear consistency can only be achieved with liposomes that are small enough to pass between cells. The smaller, more stable vesicles begin absorbing as soon as they hit the mouth.*\nThis product uses phosphatidylcholine from purified sunflower seed lecithin. It does not contain gluten.", "domain": "chemistry", "round": 3} +{"url": "http://www.abcam.com/AKT1-2-3-antibody-ab79360.html", "date": "2013-12-05T00:31:51Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2013-48/segments/1386163037902/warc/CC-MAIN-20131204131717-00031-ip-10-33-133-15.ec2.internal.warc.gz", "language_score": 0.7151906490325928, "token_count": 1571, "dump": "CC-MAIN-2013-48", "global_id": "webtext-fineweb__CC-MAIN-2013-48__0__134119845", "lang": "en", "text": "Anti-AKT1/2/3 antibody (ab79360)\n- Product nameAnti-AKT1/2/3 antibodySee all AKT1/2/3 primary antibodies ...\n- DescriptionRabbit polyclonal to AKT1/2/3\n- Specificityab79360 detects endogenous levels of total AKT1/2/3 protein.\n- Tested applicationsWB, IHC-P, ELISA more details\n- Species reactivityReacts with: Rat, Human, Culex pipiens\nPredicted to work with: Mouse\nSynthesized non-phosphopeptide derived from human AKT1/2/3 around the phosphorylation site of tyrosine 315/316/312 (P-E-YP-L-A).\n- Positive control\n- Human brain tissue and A549 cell extract.\n- Storage instructionsStore at -20°C. Stable for 12 months at -20°C\n- Storage bufferPreservative: 0.02% Sodium Azide\nConstituents: 50% Glycerol, PBS (without Mg2+ and Ca2+), 150mM Sodium chloride, pH 7.4\n- Concentration information loading...\n- PurityImmunogen affinity purified\n- Purification notesThe antibody was affinity purified from rabbit antiserum by affinity chromatography using epitope specific immunogen.\n- Clonality Polyclonal\n- Research Areas\nOur Abpromise guarantee covers the use of ab79360 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\n|WB||WB: 1/500 - 1/1000. Detects a band of approximately 48 kDa (predicted molecular weight: 56 kDa).|\n|IHC-P||IHC-P: 1/50 - 1/100.|\n- FunctionIGF-1 leads to the activation of AKT3, which may play a role in regulating cell survival. Capable of phosphorylating several known proteins. Truncated isoform 2/PKB gamma 1 without the second serine phosphorylation site could still be stimulated but to a lesser extent.\n- Tissue specificityIn adult tissues, it is highly expressed in brain, lung and kidney, but weakly in heart, testis and liver. In fetal tissues, it is highly expressed in heart, liver and brain and not at all in kidney.\n- Sequence similaritiesBelongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.\nContains 1 AGC-kinase C-terminal domain.\nContains 1 PH domain.\nContains 1 protein kinase domain.\n- DomainBinding of the PH domain to the phosphatidylinositol 3-kinase alpha (PI(3)K) results in its targeting to the plasma membrane.\nmodificationsPhosphorylation on Thr-305 and Ser-472 is required for full activity (By similarity). Phosphorylated upon DNA damage, probably by ATM or ATR.\nUbiquitinated. When fully phosphorylated and translocated into the nucleus, undergoes 'Lys-48'-polyubiquitination catalyzed by TTC3, leading to its degradation by the proteasome.\n- Cellular localizationCytoplasm. Membrane. Membrane-associated after cell stimulation leading to its translocation.\n- Entrez Gene: 10000 Human\n- Entrez Gene: 207 Human\n- Entrez Gene: 208 Human\n- Entrez Gene: 11651 Mouse\n- Entrez Gene: 11652 Mouse\n- Entrez Gene: 23797 Mouse\n- Entrez Gene: 24185 Rat\n- Entrez Gene: 25233 Rat\n- Entrez Gene: 29414 Rat\n- Omim: 164730 Human\n- Omim: 164731 Human\n- Omim: 611223 Human\n- SwissProt: P31749 Human\n- SwissProt: P31751 Human\n- SwissProt: Q9Y243 Human\n- SwissProt: P31750 Mouse\n- SwissProt: Q60823 Mouse\n- SwissProt: Q9WUA6 Mouse\n- SwissProt: P47196 Rat\n- SwissProt: P47197 Rat\n- SwissProt: Q63484 Rat\n- Unigene: 498292 Human\n- Unigene: 525622 Human\n- Unigene: 631535 Human\n- Unigene: 235194 Mouse\n- Unigene: 10506 Rat\n- Unigene: 11422 Rat\n- Unigene: 87066 Rat\n- AKT antibody\n- AKT1 antibody\n- AKT1 kinase antibody\n- AKT2 antibody\n- AKT2 kinase antibody\n- Akt3 antibody\n- AKT3_HUMAN antibody\n- CAKT antibody\n- DKFZp434N0250 antibody\n- kinase Akt1 antibody\n- MGC99656 antibody\n- Murine thymoma viral (v-akt) homolog 2 antibody\n- PKB antibody\n- PKB gamma antibody\n- PKB-GAMMA antibody\n- PKB/Akt antibody\n- PKBALPHA antibody\n- PKBB antibody\n- PKBBETA antibody\n- PKBG antibody\n- PKBGAMMA antibody\n- PRKBA antibody\n- PRKBB antibody\n- PRKBG antibody\n- Protein kinase Akt-3 antibody\n- Protein kinase B antibody\n- Protein kinase B gamma antibody\n- RAC antibody\n- rac protein kinase alpha antibody\n- rac protein kinase beta antibody\n- RAC-gamma antibody\n- RAC-gamma serine/threonine-protein kinase antibody\n- RAC-PK-gamma antibody\n- RACALPHA antibody\n- RACalpha serine/threonine kinase antibody\n- RACBETA antibody\n- RACgamma antibody\n- RACgamma serine/threonine protein kinase antibody\n- RACPKgamma antibody\n- serine threonine protein kinase antibody\n- STK-2 antibody\n- STK2 antibody\n- thymoma viral proto oncogene 1 antibody\n- thymoma viral proto oncogene antibody\n- vakt murine thymoma viral oncogene homolog 1 antibody\n- vakt murine thymoma viral oncogene homolog 2 antibody\n- vakt murine thymoma viral oncogene homolog 3 antibody\nAnti-AKT1/2/3 antibody images\nAll lanes : Anti-AKT1/2/3 antibody (ab79360) at 1/500 dilution\nLane 1 : A549 cell extract at 5 µg\nLane 2 : A549 cell extract with immunizing peptide at 5 µg\nPredicted band size : 56 kDa\nObserved band size : 48 kDa (why is the actual band size different from the predicted?)\nab79360, at 1/50 dilution, staining AKT1/2/3 in human brain tissue by Immunohistochemistry in the presence (right) or absence (left) of immunizing peptide. Formalin-fixed, paraffin-embedded section.", "domain": "chemistry", "round": 3} +{"url": "https://pubs.aip.org/avs/jva/article-abstract/34/3/031504/595697/Effect-of-microstructural-evolution-on-mechanical?redirectedFrom=fulltext", "date": "2023-09-27T21:44:27Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233510326.82/warc/CC-MAIN-20230927203115-20230927233115-00766.warc.gz", "language_score": 0.8324939012527466, "token_count": 334, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__286535137", "lang": "en", "text": "This paper examined the evolution of microstructure and its effect on the mechanical and tribological properties of ultralow friction Ti-doped diamondlike carbon (DLC) films, by adjusting the CH4/Ar ratio under constant radio frequency discharge power and bias. The Raman, high resolution transmission electron microscopy, atomic force microscope and nanoindentation measurements consistently reveal or indicate the formation of curved graphene sheets or fullerenelike nanostructures with increasing CH4/Ar ratio. The superior frictional performance (0.008–0.01) of Ti-DLC films can be attributed to the special microstructure related to the development of embedded fullerenelike nanostructures as a result of incorporation of TiO2 clusters. The contributing factors include high hardness and cohesion, excellent toughness, high load-bearing capacity, as well as the ultralow shear resistance transform layer and the excellent antioxidation stability brought by the doped Ti.\nEffect of microstructural evolution on mechanical and tribological properties of Ti-doped DLC films: How was an ultralow friction obtained?\nFei Zhao, Hongxuan Li, Li Ji, Yongjun Wang, Xiaohong Liu, Huidi Zhou, Jianmin Chen; Effect of microstructural evolution on mechanical and tribological properties of Ti-doped DLC films: How was an ultralow friction obtained?. J. Vac. Sci. Technol. A 1 May 2016; 34 (3): 031504. https://doi.org/10.1116/1.4944053\nDownload citation file:", "domain": "chemistry", "round": 3} +{"url": "https://shop.profs.works/index.php?_route_=hydro-b-nl", "date": "2023-01-31T06:13:39Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-06/segments/1674764499845.10/warc/CC-MAIN-20230131055533-20230131085533-00858.warc.gz", "language_score": 0.9152436852455139, "token_count": 434, "dump": "CC-MAIN-2023-06", "global_id": "webtext-fineweb__CC-MAIN-2023-06__0__186741514", "lang": "en", "text": "Profs Basic Hydro B\nProfs Basic Hydro B complements Basic Hydro A perfectly, adding all the missing ingredients to the feeding water. When used in the right ratio, the combination of Basic Hydro A and Basic Hydro B ensures that the plants will receive a complete nutritional diet. This product is mainly composed of phosphorus and potassium, but all other nutrients (except for calcium) are present in this product.\nProfs Basic Hydro A & B\nProfs Basic Hydro A & B are two professional, fast-acting fertilizers that, together, provide all the essential elements that a plant needs during its growth and flowering phase. Basic Hydro stimulates both growth and fruiting and imparts the plant's characteristic savour. It is particularly intended for cultivation based on coconut or hydroculture.\nBasic Hydro nutrition meets the changing needs of the plant. During its growth phase, your plant needs higher amounts of nitrogen; during flowering, it needs much less, but needs more of elements like phosphorus and potassium. You can cater to this by using A and B separately. Start with more A and end with more B. We therefore advise you to always use Hydro A in conjunction with Hydro B and closely keep to the cultivation schedule.\nAdvantages of using Profs Basic Hydro A & B\n• Stimulates fruiting and flavour\n• Contains just the right amounts of nitrogen, phosphorus and potassium and\nis rich in trace elements in a form that can directly be taken up by the plant to assure you of exuberant growth and flowering.\n• The lack of impurities in the Basic Hydro A & B fertilizers means they have no tendency to acidify or contaminate your medium\nWhy it's in two parts, A & B\nProfs Basic Hydro consists of two parts, part A and part B, and for good reason. It can happen that combining some of the elements in parts A and B results in them agglomerating. The plant cannot then process these molecules. Into the feed water you therefore need to pour the A component first and only then add the B component. We always advise you to follow the Profs Mineral Hydro schedule.", "domain": "chemistry", "round": 3} +{"url": "https://pparsignaling.com/2008-cell-tested-dsi-applying/", "date": "2021-10-25T14:57:35Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-43/segments/1634323587711.69/warc/CC-MAIN-20211025123123-20211025153123-00339.warc.gz", "language_score": 0.9129076600074768, "token_count": 742, "dump": "CC-MAIN-2021-43", "global_id": "webtext-fineweb__CC-MAIN-2021-43__0__30104586", "lang": "en", "text": ", 2008). For each cell, we tested DSI before and after applying THL to confirm inhibition of 2-AG synthesis. In 4 of 9 cells (44%), THL increased IPSC amplitude, consistent with relief from tonic 2-AG-mediated suppression; in the remaining 5 cells, THL alone had no effect. Selleckchem ZVADFMK In 6 of\n9 (67%) cells, both THL-sensitive (4 cells; Figures 3A and 3B) and THL-insensitive (2 cells; data not shown) E2 (100 nM) decreased IPSC amplitude in the presence of THL by 59% ± 7% (Figure 3B). We confirmed that DSI was blocked by THL, indicating inhibition of 2-AG synthesis, before E2 was applied (Figure 3C). Thus, inhibiting 2-AG synthesis failed to block E2-induced IPSC suppression, a first indication that 2-AG is not required for E2-induced suppression of IPSCs. There is no selective inhibitor of AEA synthesis available. As an alternative, OSI-906 manufacturer we compared the effect of blocking breakdown of AEA versus 2-AG using selective inhibitors of fatty acid amide hydrolase (FAAH, for AEA) or monoacylglycerol lipase (MGL, for 2-AG). Because such inhibitors increase levels of their respective endocannabinoids, we reasoned that inhibition of endocannabinoid degradation might occlude E2′s ability to suppress IPSCs. The FAAH inhibitor URB 597 (URB, 1 μM)\ndecreased IPSC amplitude in 11 of 14 (79%) cells by 47% ± 4% (Figures 3D and 3E), indicating tonic accumulation of AEA, whereas in the Chlormezanone remaining 3 cells, URB had no effect. Importantly, E2 (100 nM) applied\nin the presence of URB induced no further decrease in IPSC amplitude (4% ± 2%; Figure 3E), indicating that inhibition of FAAH completely occluded E2-induced IPSC suppression. Similarly, E2 had no effect on IPSC amplitude in the 3 URB-insensitive cells (1% ± 4%). Consistent with the role of 2-AG rather than AEA in mediating DSI in the hippocampus (Kim and Alger, 2004 and Pan et al., 2009), DSI was unaffected by URB (Figure 3F). These findings suggested that AEA mediates E2-induced IPSC suppression. To corroborate interpretation of results with URB, we performed analogous experiments with the MGL inhibitor JZL 184 (JZL, 100 nM), which blocks breakdown of 2-AG (Pan et al., 2009). Because inhibition of 2-AG synthesis by THL failed to block E2-induced IPSC suppression, we hypothesized that inhibiting 2-AG breakdown with JZL would fail to occlude E2-induced IPSC suppression. In 13 of 16 cells (81%), JZL decreased IPSC amplitude by 37% ± 3% (Figures 3G and 3H). Once a stable baseline in JZL was established (∼40 min), we applied E2 (100 nM) to determine whether further IPSC suppression was possible. In contrast to results with URB, E2 applied in the presence of JZL decreased IPSC amplitude by 49% ± 5% in 9 of 16 cells (Figure 3H), almost identical to the effect of E2 alone.", "domain": "chemistry", "round": 3} +{"url": "https://denresidence.com/lv-400-vs-amine-400/", "date": "2024-02-26T17:52:29Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707947474661.10/warc/CC-MAIN-20240226162136-20240226192136-00571.warc.gz", "language_score": 0.9110897183418274, "token_count": 1390, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__12843415", "lang": "en", "text": "Weeds are a huge problem for our precious gardens and lawns. Fortunately, herbicides are a simple solution to get rid of them. But not all herbicides can work in the same conditions.\nGordon’s LV 400 and Amine 400 are well-known herbicides that are used by people all over the country. Using herbicides without knowing their differences can prove to be harmful.\nSo, in this article, we shall end Gordon’s LV 400 vs. Amine 400 debate.\nLV 400 And Amine 400 Differences\nThe LV 400 and Amine 400 are different types of herbicides intended for different use cases. We have discussed the basic properties of the two herbicides.\nIf you are wondering what is the difference between Amine 400 and LV 400, you will find the answer here.\nThe dissimilarities between LV 400 and Amine 400 are mainly due to their different compositions.\nThe main differences between these two herbicides can be summarized in the following 3 points.\n- Chemical structure\n- Usage temperature\n- External factors\nLet us see how these three matters influence the LV 400 and Amine 400.\n- Chemical Structure\nThe main difference between the two herbicides arises from the difference between their chemical structures. Gordon’s LV 400 is essentially an ester-based herbicide solution.\nOn the other hand, Amine 400 is a water-based amine solution that is used as a herbicide.\nThe ester-based LV 400 is more volatile than the Amine 400. Amines are less soluble in the plant body. Due to their higher solubility, esters can act on weeds more efficiently than amines.\nThat’s why the LV 400 can kill the weeds between grasses without harming the grass.\nThe Amine 400 is water-soluble. So, it can be mixed with other products. The LV 400 cannot be mixed with other solutions. LV 400 has higher vapor pressure compared to the Amine 400.\nThese are the main chemical differences between them.\n- Usage Temperature\nTemperature is one of the main differentiating factors of LV 400 and Amine 400. Esters are more volatile, so they don’t work as well when the temperature is very high.\nAmines can work in relatively higher temperatures due to being less volatile.\nGordon’s LV 400 is used when the temperature is below 60° F. In the cooler months of the year, you should use the LV 400. If you use ester-based herbicides at too high temperatures, it may cause harm to the grass and work poorly.\nThe Amine 400 should be used when the temperature is between 60° F and 90° F. The warmer months are suitable periods to apply Amine 400.\nSo, the temperature should be considered when applying herbicides.\n- External Factors\nFactors such as wind drift, wind direction, pressure, and usage area can greatly influence the ability of herbicides. If the usage area has heavy drifts, then the Amine 400 should be used.\nIf the area has high pressure, Amine 400 is suitable.\nFor grasslands, LV 400 is more efficient. When there is too much wind speed, the application of herbicide should be paused.\nIt can be said that whether you need the LV 400 or the Amine 400 depends on the factors of your location.\nDifferent times of the year demand different herbicides. Proper timing is a driving factor for the effective use of herbicides.\nIf the temperature or pressure is too high, neither herbicide will work. Keep these things in mind when choosing herbicides.\nBasic Properties of Gordon’s LV 400 and Amine 400 Herbicides\nTo distinguish between the two types of fertilizers, you have to know the basic properties of Gordon’s LV 400 and Amine 400.\nLet us discuss the properties and use cases of these two herbicides.\nGordon’s LV 400\nGordon’s LV 400 is classified as a “solvent-free weed killer concentration”. It is well known and used by professionals and gardeners.\nThe company claims that it can kill over 90 types of broadleaf weeds. Our testing has proved that it can control almost all the common weeds properly.\nThe LV 400 is a liquid herbicide concentration. It is usable in small to large-sized gardens, lawns, pastures, and grasslands. It can kill weeds while leaving the grass untouched.\nChemically, the LV 400 is an ester-based solution. That is why Gordon’s LV 400 is absorbed quickly by plants. The LV 400 is best used when the temperature is lower than 60° F. It does not perform properly in warmer climates.\nThe temperature is an important factor for herbicides. During March, April and May, the weather is cooler. This is the proper usage period for ester-based herbicides such as LV 400.\nThe optimum working temperature of Gordon’s LV 400 should be mentioned in the label.\nGordon’s Amine 400\nGordon’s Amine 400 is a water-based herbicide concentration. It is effective on small weeds and weeds that are still growing.\nThe Amine 400 can be mixed with other solutions to increase its effectiveness.\nThe Amine 400 can be used in lawns, pastures, crops such as corn, and ornamental gardens. It has been tested to control nearly 90 types of weeds. It is to be applied two times per year.\nThe Amine 400 is chemically an amine and water solution. Amine solutions can be used in temperatures higher than 60° F and lower than 90° F.\nGenerally, amine-based herbicides are used in larger land areas where wind speed is a problem.\nAmine 400 cannot selectively attack the weeds while leaving out the grass. It is less soluble in plants because they are highly soluble in water.\nFrequently Asked Questions (FAQs)\nBeing phenoxy type herbicide, it can kill almost all the broadleaf weeds.\nYes, amine 400 can kill clover.\nAmine 400 is used to control all the unwanted broadleaf weeds.\nIt can take up to 6 to 8 hours to dry after the application.\nThe Gordon’s LV 400 vs. Amine 400 argument is a long-running one. However, it is true that using either one exclusively will not yield good results.\nTo properly use these herbicides, you must know what sets them apart.\nYour land is precious to you, and you want to keep it free from weeds. Only by utilizing the proper use of Gordon’s LV 400 and Amine 400 can you achieve the ideal result.", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/cacna2d2-antibody-epr12343-ab173293.html", "date": "2019-12-11T16:39:18Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-51/segments/1575540531974.7/warc/CC-MAIN-20191211160056-20191211184056-00287.warc.gz", "language_score": 0.7743218541145325, "token_count": 1073, "dump": "CC-MAIN-2019-51", "global_id": "webtext-fineweb__CC-MAIN-2019-51__0__148412813", "lang": "en", "text": "Product nameAnti-CACNA2D2 antibody [EPR12343]\nSee all CACNA2D2 primary antibodies\nDescriptionRabbit monoclonal [EPR12343] to CACNA2D2\nTested applicationsSuitable for: IP, WBmore details\nUnsuitable for: ICC or IHC-P\nSpecies reactivityReacts with: Mouse, Rat, Human\nRecombinant fragment within Human CACNA2D2 aa 50-200. The exact sequence is proprietary.\nDatabase link: Q9NY47\n- Fetal lung, fetal brain and Human cerebellum lysates.\nStorage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.\nStorage bufferpH: 7.20\nPreservative: 0.01% Sodium azide\nConstituents: 9% PBS, 40% Glycerol, 0.05% BSA, 50% Tissue culture supernatant\nPurityTissue culture supernatant\nOur Abpromise guarantee covers the use of ab173293 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\n|IP||1/10 - 1/100.|\n|WB||1/1000 - 1/10000. Predicted molecular weight: 130 kDa.|\nFunctionThe alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) and possibly T-type (CACNA1G). Overexpression induces apoptosis.\nTissue specificityPredominantly present in cerebellar cortex. Present in various lung tumor cell lines, while it is absent in normal lung (at protein level). Highly expressed in heart, lung, testis, pancreas and skeletal muscle. Also expressed in kidney, liver, placenta and brain.\nSequence similaritiesBelongs to the calcium channel subunit alpha-2/delta family.\nContains 1 cache domain.\nContains 1 VWFA domain.\nDomainThe MIDAS-like motif in the VWFA domain binds divalent metal cations and is required to promote trafficking of the alpha-1 (CACNA1) subunit to the plasma membrane by an integrin-like switch.\nmodificationsMay be proteolytically processed into subunits alpha-2-2 and delta-2 that are disulfide-linked. It is however unclear whether such cleavage really takes place in vivo and has a functional role.\nCellular localizationMembrane. Colocalizes with CACNA1A in lipid raft fractions.\n- Information by UniProt\n- Alpha 2 delta calcium channel subunit antibody\n- CA2D2_HUMAN antibody\n- CACNA2D antibody\nLane 1: Wild-type HAP1 cell lysate (20 µg)\nLane 2: CACNA2D2 knockout HAP1 cell lysate (20 µg)\nLane 3: HeLa cell lysate (20 µg)\nLane 4: Human brain tissue lysate (20 µg)\nLanes 1 - 4: Merged signal (red and green). Green - ab173293 observed at 160 kDa. Red - loading control, ab8245, observed at 37 kDa.\nab173293 was shown to specifically react with CACNA2D2 when CACNA2D2 knockout samples were used. Wild-type and CACNA2D2 knockout samples were subjected to SDS-PAGE. ab173293 and ab8245 (loading control to GAPDH) were diluted at 1/5000 and 1/10000 respectively and incubated overnight at 4°C. Blots were developed with Goat anti-Rabbit IgG H&L (IRDye® 800CW) preadsorbed ab216773 and Goat anti-Mouse IgG H&L (IRDye® 680RD) preadsorbed ab216776 secondary antibodies at 1/10000 dilution for 1 hour at room temperature before imaging.\nAll lanes : Anti-CACNA2D2 antibody [EPR12343] (ab173293) at 1/1000 dilution\nLane 1 : Fetal lung lysate\nLane 2 : Fetal brain lysate\nLane 3 : Human cerebellum lysate\nLysates/proteins at 10 µg per lane.\nPredicted band size: 130 kDa\nWestern blot analysis on immunoprecipitation pellet from fetal brain lysate using ab173293.\nab173293 has not yet been referenced specifically in any publications.", "domain": "chemistry", "round": 3} +{"url": "http://juteeast5.blogminds.com/concrete-crack-repair-8987649", "date": "2020-01-27T12:28:58Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-05/segments/1579251700675.78/warc/CC-MAIN-20200127112805-20200127142805-00262.warc.gz", "language_score": 0.9341868758201599, "token_count": 802, "dump": "CC-MAIN-2020-05", "global_id": "webtext-fineweb__CC-MAIN-2020-05__0__129527274", "lang": "en", "text": "Concrete Crack RepairThe use of carbon fiber staples is an effective approach to permanently fix poured-wall basement cracks, when used in conjunction with an epoxy injection polymer. The tensile strength of cured epoxy is typically 7000 psi whereas the tensile strength of concrete is in the range of 300 - 700 psi; clearly, the bond strength of epoxy is much greater than that of the foundation wall; making epoxy a good choice for foundation wall structural crack repair.\nPolyurethane foams harden very rapidly (unlike most epoxies) and are less likely to flow out the back of some cracks as epoxies may. The cure time associated with polyurethane does vary, even among crack injections using the Epoxy Injection same formulation. Crack injection concrete repair can be completed using air guns, hand-actuated delivery systems, spring- or balloon-actuated capsules, or single- or dual-component injection electric or air-driven pumps.\nThe injected epoxy typically cures within 5 hours and bonds the two sides of the crack together in addition to filling the crack through the entire thickness of the foundation wall (typically 8″), thereby sealing the crack permanently because the crack essentially no longer exists; this is the ultimate concrete crack repair.\nVector Construction offers installations with a wide selection of specialized materials for architectural precast panels, underwater, low and high application temperatures, high structure temperatures, chemical and radiation resistance, large voids, narrow cracks, plate bonding, wooden beams, and structures subject to vibration during installation.\nWhile epoxy crack injections are not as versatile as polyurethane crack injections , for example, the repair of actively leaking cracks contributing to a wet basement, the use of epoxy is nonetheless a very effective means of repairing concrete cracks and preventing potential basement leaks.\nGoes on like 'Spackle', but five times stronger than concrete, and has 4 times the bonding power to concrete vs. mortar type crack repairs. They can be repaired by filling with Portland cement grout. Since 1979 Akton Injection has specialized in the repair of concrete and concrete block foundation cracks.\nConcrete poured during high daytime temperatures will contract as it cools during the night, this can be sufficient enough to cause cracking if the concrete is restrained. The two component epoxy resin forcibly seals horizontal structural cracks and provides reinforcement to the cracked area to become more robust than the un-cracked area surrounding it.\nJust give us a call and our team of foundation repair specialists will work with you to find the best product and most cost effective method to achieve a successful, permanent foundation repair. If epoxy is injected while the crack is leaking, the water seepage might actually create channels through the epoxy, creating leaks in the new repair.\nIn this method, mixtures of grout may contain cement and water or cement plus sand and water, depending on the width of the crack. Most cracks develop within 30 days of the concrete being poured, whether or not leaking during this period. Spencer says the only time contractors don't seal a slab is when water is already flooding the basement through the floor cracks.\nDo not allow epoxy to block the port or the crack under it, this is where epoxy must enter the crack. As a consequence, the formerly cracked area has strength exceeding that of forces that would otherwise cause the repaired area from opening outwardly. Both Epoxy resins and polyurethanes are sensitive to water.\nNote: The strong epoxy bond is often cited as a negative attribute of epoxy crack injections due to its rigidity. Unfortunately, crack injection is only viable for poured foundations. It is during this step that epoxy resin is injected into the foundation crack. We can take care of both interior and exterior foundation cracks We understand that there are wall crack repair kits sold at your town's home improvement stores, but the materials inside are nowhere near as effective as what we can provide for you.", "domain": "chemistry", "round": 3} +{"url": "https://euroliquids.co.in/product/rowe-greases/hightec-greaseguard-alltemp-2", "date": "2020-07-11T02:21:06Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-29/segments/1593655919952.68/warc/CC-MAIN-20200711001811-20200711031811-00441.warc.gz", "language_score": 0.9198833107948303, "token_count": 320, "dump": "CC-MAIN-2020-29", "global_id": "webtext-fineweb__CC-MAIN-2020-29__0__208455990", "lang": "en", "text": "Premium, multi-purpose lubricating grease based on a lithium complex soap for use in rolling and sliding bearings with long lubrication intervals and high steady-state temperatures.\nHIGHTEC GREASEGUARD ALLTEMP 2 is a multi-purpose grease produced using selected base oils and lithium-based thickeners.\nThe quality of this product is equivalent to EU regulations\nAdditionally this product is recommended when thefollowing filling instructions are required\nHIGHTEC GREASEGUARD ALLTEMP 2 is used as a multi-purpose grease for lubricating rolling and sliding bearings subjected to high pressure loads, even at increased temperatures. It is particularly suitable for lubricating high-load wheel bearings in commercial vehicles and high-speed wheel bearings in passenger cars. The frequency of the lubrication intervals is reduced at steady-state temperatures exceeding 160°C!\nIf stored appropriately in originally sealed containers in a dry place, away from direct sunlight and at temperatures between 10°C and 30°C, the minimum storage period is 24 months.\nA safety data sheet is available upon request for information on health, safety and environmental aspects. A little oil separation is caused by the product's attributes and harmless.\nIt is desirable to a certain extent to ensure lubrication, and no indication of inferior product quality. The separated oil can be incorporated again homogenously by folding it in comprehensively.\nHave a question or proposal in mind? Get in touch with us. We will connect you withing 24 hours.\nHave a question or proposal in mind? Get in touch with us.", "domain": "chemistry", "round": 3} +{"url": "http://pathwaymaps.com/maps/533", "date": "2019-07-22T02:03:25Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2019-30/segments/1563195527458.86/warc/CC-MAIN-20190722010436-20190722032436-00345.warc.gz", "language_score": 0.7371216416358948, "token_count": 1364, "dump": "CC-MAIN-2019-30", "global_id": "webtext-fineweb__CC-MAIN-2019-30__0__106092119", "lang": "en", "text": "Ca('2+) cytosol, PI3K reg class IA, SPHK1, MEK2 (MAP2K2), PtdIns(3,4,5)P3, PKC-alpha, PI3K cat class IA, PKC, PtdIns(4,5)P2, Ca('2+) = Ca('2+), 2.7.1.-, NO, c-Src, VEGFR-2, PLC-gamma 1, AKT(PKB), Neurofibromin, MEK1 (MAP2K1), c-Raf-1, IKK-beta, (L)-Arginine (cytosol), eNOS, DAG, sphingosine, Sphingosine 1-phosphate, H-Ras, IKK-alpha, 18.104.22.168, IKK-gamma, (L)-Citrulline cytosol, Ca('2+) endoplasmic reticulum lumen, I-kB, NF-kB p50/p65, IP3, ERK1/2, 22.214.171.124, CCL2, c-Jun, p120GAP, PKC-beta, IP3 receptor, VEGF-A, c-Jun/c-Fos, 126.96.36.199, IKK (cat)\nVEGF signaling via VEGFR2 - generic cascades\nVascular endothelial growth factor ( VEGF ) family of ligands and receptors is crucial for vascular development and neovascularization in physiological and pathological processes in both embryo and adult . VEGFs denote a family of homodimeric glycoproteins, which currently consists of five members ( VEGF-A, VEGF-B, VEGF-C, VEGF-D, and Placenta growth factor ( PLGF )).\nVEGFR-2 is a high-affinity receptor for VEGF-A . Activated VEGFR-2 binds Phospholipase C gamma 1 ( PLC-gamma 1 ) leading to its phosphorylation and activation, which results in hydrolysis of the membrane Phosphatidylinositol (4,5)-bisphosphate ( PtdIns(4,5)P2 ) and generation of the second messengers 1,2-diacylglycerol ( DAG ) and Inositol (1,4,5)-trisphosphate ( IP3 ). DAG is a physiological activator of Protein kinase C beta 1 ( PKC-beta ), whereas IP3 binds to a specific receptor present on endoplasmic reticulum, resulting in the release of intracellular stored Ca(2+) .\nPKC-beta phosphorylates and activates V-raf-1 murine leukemia viral oncogene homolog 1 ( c-Raf-1 ) triggering Mitogen-activated protein kinase kinase 1 ( MEK1 (MAP2K1) ) and Mitogen-activated protein kinase kinase 2( MEK2 (MAP2K2) )/ Mitogen-activated protein kinase 3/1 ( ERK1/2 ) signaling cascade. ERK1/2 can also be activated through PKC/ Sphingosine kinase 1 ( SPHK1 ) pathway . SPHK1 is an enzyme which catalyses Spingosine 1 phosphate formation from Sphingosine. Decrease of Sphingosine concentration and increase of sphingosine 1-phosphate may lead to activation of V-Ha-ras Harvey rat sarcoma viral oncogene homolog ( H-Ras ) through inhibition of Neurofibromin and RAS p21 protein activator 1 ( p120GAP ). H-Ras in turn binds to and activates c-Raf-1 leading to ERK1/2 activation. Activated ERK1/2 activates Jun oncogene ( c-Jun ) by phosphorylation. The latter forms a complex with V-fos FBJ murine osteosarcoma viral oncogene homolog ( c-Fos ) protein leading to DNA synthesis and cell proliferation , .\nDAG is also a physiological activator of PKC-alpha which can signal through Conserved helix-loop-helix ubiquitous kinase ( IKK-alpha ) and Inhibitor of kappa light polypeptide gene enhancer in B-cells kinase beta ( IKK-beta ) to Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor ( I-kB)/Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 and V-rel reticuloendotheliosis viral oncogene homolog A ( NF-kB p50/p65 ) pathway. NF-kB p50/p65 together with c-Jun/c-Fos activate transcription of Chemokine ligand 2 ( CCL2 ) , \nVEGFR-2 also binds and activates Phosphoinositide-3-kinase regulatory subunit (PI3K reg class IA ) , followed by activation of catalytic subunits of PI3K - PI3K cat class IA, which, then results in an increase in lipid Phosphatidylinositol 3,4,5-triphosphate ( PtdIns(3,4,5)P3 ) and activation of V-akt murine thymoma viral oncogene homolog 1 ( AKT(PKB) ).\nAKT(PKB) signaling pathway regulates cellular survival by inhibiting pro-apoptotic pathways . AKT(PKB) can directly phosphorylate Nitric oxide synthase 3 ( eNOS ) leading to nitric oxide production , . Another mechanism of eNOS activation involves V-src sarcoma viral oncogene homolog ( c-Src ) and PLC-gamma 1: VEGF-A receptor binding causes c-Src activation with subsequent phosphorylation of PLC-gamma 1 leading to increases in intracellular levels of IP3 and elevation of intracellular calcium. Increase in intracellular calcium concentration stimulates Nitric oxide synthase 3 ( eNOS ) to produce nitric oxide .", "domain": "chemistry", "round": 3} +{"url": "https://www.istc.int/en/projects?status=8&by=tech_area&s_tech=10570", "date": "2021-09-22T09:16:03Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-39/segments/1631780057337.81/warc/CC-MAIN-20210922072047-20210922102047-00350.warc.gz", "language_score": 0.8148701190948486, "token_count": 564, "dump": "CC-MAIN-2021-39", "global_id": "webtext-fineweb__CC-MAIN-2021-39__0__224891084", "lang": "en", "text": "Sintering and Joining of Ceramic and Composite Materials by Using Millimeter-wave Radiation.\nLuminescent Optical Ceramics for X-rays Medical Techniques\nPhysico-Chemical Bases of Aluminium Oxide Aerogel Synthesis and Development of Continuous Technology for its Production from a Ga-Al Liquid Metal System\nStudy of Plutonium Ceramics Alteration under Conditions of Underground Disposal\nDesign and Fabrication of Magnetic Field Sensors and Devices Controlled by Magnetic Field on the Base of Colossal Magnetoresistance Materials\nDeveloping of Code for Modeling of the Processes of Ceramics Pressing\nDevelopment of Wear-Resisting Materials “Aluminum Alloy-Ceramic Coating” Produced by Shaped Casting and Plasmoelectrolitic Oxidation\nCorrelation of Electron Properties of Individual Carbon Nanotubes, Atomic Structure and Parameters of Catalytic Synthesis\nFabrication of Nanostructures on the Base of Oxides of Mixed Valence Metals and Investigation of their Structural, Magnetic and Electron Properties\nMethods of Improving Alumina Ceramics Strength\nSynthesis of New Low-Dimensional Metal-Oxide Compounds with Spin Gaps and Determination of Their Fundamental Сharacteristics\nFormation of Grain Boundaries in Optical Nanoceramics\nDevelopment of Technological Grounds for Creation of High Performance Single-Walled Nanotube Electronic Devices\nNew Generation Highly Effective Electro- and Light-Active Nonlinear Oriented Tape Glass-Ceramics on the Basis of Stoichiometric Three-Coordinated Borates\nNew Lead & Alkali Free Low Melting Sealing Glass Frits & Ceramic Fillers\nAlkaline-Earth Aluminum Borates as a Basis of Developing New Kinds of Glass Ceramics\nThe Development of the Thermal Shock Resistance Aluminum-Oxide Vacuum Tight Ceramics\nRafaelites - Basis for Developing of New Multi-Purpose Glass Ceramics\nCalcium Phosphate Bio-Ceramics from Calcium Olygophosphates\nDevelopment of Technology for Production of Ceramic Articles from Beryllium Oxide by Using the Method of Moulding with Ultrasound\nThe International Science and Technology Center (ISTC) is an intergovernmental organization connecting scientists from Kazakhstan, Armenia, Tajikistan, Kyrgyzstan, and Georgia with their peers and research organizations in the EU, Japan, Republic of Korea, Norway and the United States.\nISTC facilitates international science projects and assists the global scientific and business community to source and engage with CIS and Georgian institutes that develop or possess an excellence of scientific know-how.", "domain": "chemistry", "round": 3} +{"url": "https://www.moluna.de/buch/4204341-biological+reactive+intermediates+iv/", "date": "2017-06-23T19:13:36Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-26/segments/1498128320130.7/warc/CC-MAIN-20170623184505-20170623204505-00504.warc.gz", "language_score": 0.7501067519187927, "token_count": 3558, "dump": "CC-MAIN-2017-26", "global_id": "webtext-fineweb__CC-MAIN-2017-26__0__202832993", "lang": "en", "text": "Sessions I - VI.- Cytochrome P-450 Oxidations and the Generation of Biologically Reactive Intermediates.- Formation of Reactive Intermediates by Phase II Enzymes: Glutathione-Dependent Bioactivation Reactions.- Role of the Well-Known Basic and Recently Discovered Acidic Glutathione S-Transf erases in the Control of Genotoxic Metabolites.- Bioactivation of Xenobiotics by Flavin-Containing Monooxygenases.- Formation of Biological Reactive Intermediates By Peroxidases: Halide Mediated Acetaminophen Oxidation and Cytotoxicity.- Peroxyl Free Radicals: Biological Reactive Intermediates Produced During Lipid Oxidation.- Biological Significance of Active Oxygen Species: In Vitro Studies on Singlet Oxygen-Induced DNA Damage and on the Singlet Oxygen Quenching Ability of Carotenoids, Tocopherols and Thiols.- Physiological and Toxicological Roles of Hydroperoxides.- Overview: Theoretical Aspects of Isotope Effects on the Pattern of Metabolites Formed by Cytochrome P-450.- S-Thiolation of Protein Sulfhydryls.- Cytochrome P-450 as a Target of Biological Reactive Intermediates.- Hapten Carrier Conjugates Associated with Halothane Hepatitis.- Metabolism of Drugs by Activated Leukocytes: Implications for Drug-Induced Lupus and Other Drug Hypersensitivity Reactions.- Formation of Reactive Metabolites and Appearance of Anti-Organelle Antibodies in Man.- Formation of a Protein-Acetaldehyde Adduct in Liver During Chronic Alcohol Exposure.- Dose-Response Relationships in Chemical Carcinogenesis: From DNA Adducts to Tumor Incidence.- The Single Cell Gel (SCG) Assay: An Electrophoretic Technique for the Detection of DNA Damage in Individual Cells.- Monitoring Human Exposure to Environmental Carcinogens.- Comparing the Frequency and Spectra of Mutations Induced When an SV40-Based Shuttle Vector Containing Covalently Bound Residues of Structurally-Related Carcinogens Replicates in Human Cells.- Molecular Targets of Chemical Mutagens.- Mutagenic Consequences of the Alteration of DNA by Chemicals and Radiation.- Gene Specific Damage and Repair After Treatment of Cells with UV and Chemotherapeutical Agents.- Proto-Oncogene Activation in Rodent and Human Tumors.- Short Communications.- Toxicity of 3-Methyleneoxindole, A Proposed Reactive Intermediate in the Metabolism of 3-Methylindole.- The Role of Cytochrome P450IIE1 in Bioactivation of Acetaminophen in Diabetic and Acetone-Treated Mice.- Arylamine-Induced Hemolytic Anemia: Electron Spin Resonance Spectrometry Studies.- Selective Alterations in the Profiles of Newly Synthesized Proteins by Acetaminophen (APAP) and Its Dimethylated Analogues: Relationship to Oxidative Stress.- Benzene Metabolism by Two Purified, Reconstituted Rat Hepatic Mixed Function Oxidase Systems.- Stereochemical Induction of Cytochrome P450IVA1 (P452) and Peroxisome Proliferation in Male Rat.- Cyanide Liberation and Oxidative Stress by Organothiocyanates, Organonitriles and Nitroprusside in Isolated Hepatocytes.- Mixed Function Oxidase Enzyme Responses to In Vivo and In Vitro Chromate Treatment.- Fatty Acid ?-Oxidation-Dependent Bioactivation of 5,6-Dichloro-4-Thia-5-Hexenoate and Analogs in Isolated Rat Hepatocytes.- Role of the Acetone Inducible P-450IIE1 in the Deethylation of Diethylnitrosamine In Hamster.- Stereochemistry of the Microsomal Glutathione S-Transferase-Catalyzed Addition of Glutathione to Chlorotrifluoroethene in Isolated Rat Hepatocytes.- The Pathophysiological Significance of Reactive Oxygen Formation in Rat Liver.- Oxidative Stress During Hypoxia in Isolated-Perfused Rat Heart.- Alteration of Growth Rate and Fibronectin by Imbalances in Superoxide Dismutase and Glutathione Peroxidase Activity.- The Antidotal Activity of the Thiol Drug Diethyldithiocarbamate Against N-Acetyl-p-Benzoquinone Imine in Isolated Hepatocytes.- Two Classes of Azo Dye Reductase Activity Associated with Rat Liver Microsomal Cytochrome P-450.- Expression of a cDNA Encoding Rat Liver DT-Diaphorase in Escherichia Coli.- Suicidal Inactivation of Cytochrome P-450 by Halothane and Carbon Tetrachloride.- Structure-Activity Relationships of Acrylate Esters: Reactivity Towards Glutathione and Hydrolysis by Carboxylesterase In Vitro.- Glutathione Conjugates of Hydralazine Formed in Theperoxidase/Hydrogen Peroxide/Glutathione System.- Contribution of 3,4-Dichlorophenylhydroxylamine in Propanil-Induced Hemolytic Anemia.- A Reduction in Mixed Function Oxidases and in Tumor Promoting Effects of Ethanol in a NDEA-Initiated Hepatocarcinogenesis Model.- Selective Inducers of the Coh-Locus Enhance the Metabolisms of Cou marin- and of Quinoline-Derivatives But Not That of Naphthalenes.- Primaquine-Induced Oxidative Stress in Isolated Hepatocytes as a Result of Reductive Activation.- Nitroprusside: A Potpourri of Biologically Reactive Intermediates.- Denitrosation of N-Nitrosodimethylamine in the Rat In Vivo.- Effect of Phenol and Catechol on the Kinetics of Human Myeloperoxidase-Dependent Hydroquinone Metabolism.- Activation of 1-Hydroxymethylpyrene to an Electrophilic and Mutagenic Metabolite by Rat Hepatic Sulfotransferase Activity.- Bioactivation of 2,6-Di-Tert-Butyl-4-Methyl Phenol (BHT) and Hydroxylated Analogues to Toxic Quinoid Metabolites.- Further Evidence for the Role of Myeloperoxidase in the Activation of Benzo[A]Pyrene-7,8-Dihydrodiol by Polymorpho-Nuclear Leukocytesm.- Quinones and Their Glutathione Conjugates as Irreversible Inhibitors of Glutathione S-Transferases.- Cytochrome P450 IA2 Activity in Man Measured by Caffeine Metabolism: Effect of Smoking, Broccoli, and Exercise.- Tissue Difference in Expression of Cytochrome P-450 Between Liver and Lung of Syrian Golden Hamsters Treated with 3-Methylcholanthrene.- Session VII - XII.- Role of Calcium in Toxic and Programmed Cell Death.- Molecular Mechanisms of ?-Diketone Neuropathy.- Microtubule Assembly Is Altered Following Covalent Modification by the n-Hexane Metabolite 2,5-Hexanedione.- The Role of Hepatic Metabolites of Benzene in Bone Marrow Peroxidase-Mediated Myelo- and Genotoxicity.- Glutathione Conjugation as a Mechanism of Targeting Latent Quinones to the Kidney.- Hepatic Bioactivation of 4-Vinylcyclohexene to Ovotoxic Epoxides.- Testicular Metabolism and Toxicity of Halogenated Propanes.- Lung Vascular Injury from Monocrotaline Pyrrole, a Putative Hepatic Metabolite.- Reactive Oxygen Species in the Progression of CCl4-Induced Liver Injury.- Parenchymal and Nonparenchymal Cell Interactions in Hepatotoxicity.- Signal Paths and Regulation of Superoxide, Eicosanoid, and Cytokine Formation in Macrophages of Rat Liver.- Reactive Metabolites from N-Nitrosamines.- Bisfuranoid Mycotoxins: Their Genotoxicity and Carcinogenicity.- Covalent Bonding of Bay-Region Diol Epoxides to Nucleic Acids.- Electrophilic Sulfuric Acid Ester Metabolites of Hydroxy-Methyl Aromatic Hydrocarbons as Precursors of Hepatic Benzylic DNA Adducts In Vivo.- Heterocyclic Amines: New Mutagens and Carcinogenes in Cooked Foods.- Acetaminophen and Protein Thiol Modification.- Formation and Reactivity of a Quinone Methide in Biological Systems.- Mechanisms for Pyrrolizidine Alkaloid Activation and Detoxification.- Sulfur Conjugates as Putative Pneumotoxic Metabolites of the Pyrrolizidine Alkaloid, Monocrotaline.- The Metabolism of Benzene to Muconic Acid, A Potential Biological Marker of Benzene Exposure.- Lessons on the Second Cancers Resulting from Cancer Chemotherapy.- Genetic Polymorphism of Drug Metabolism in Humans.- Human Health Risk Assessment and Biological Reactive Intermediates: Hemoglobin Binding.- Quantitating the Production of Biological Reactive Intermediates in Target Tissues: Example, Dichloromethane.- Trapping of Reactive Intermediates by Incorporation of 14C-Sodium Cyanide During Microsomal Oxidation.- Multiple Bioactivation of Chloroform: A Comparison Between Man and Experimental Animals.- Short Communications.- CCl4-Induced Cytochrome P-450 Loss and Lipid Peroxidation in Rat Liver Slices.- Alteration of Benzo(A)Pyrene-DNA Adduct Formation by Rats Exposed to Simple Mixtures.- Comparison of the Toxicity of Naphthalene and Naphthalene-1,2-Dihydrodiol (DIOL).- Selective Binding of Acetaminophen (APAP) to Liver Proteins in Mice and Men.- Post-Treatment Protection with Piperonyl Butoxide Against Acetaminophen Hepatotoxicity is Associated with Changes in Selective But Not Total Covalent Binding.- Covalent Binding of a Halothane Metabolite and Neoantigen Production in Guinea Pig Liver Slices.- Extensive Alteration of Genomic DNA and Rise in Nuclear Ca2+In Vivo Early After Hepatotoxic Acetaminophen Overdose in Mice.- The Possible Role of Glutathione on the Hepatotoxic Effect of Papaverine Hydrochloride In Vitro.- In Vivo and In Vitro Evidence for In Situ Activation and Selective Covalent Binding of Acetaminophen (APAP) in Mouse Kidney.- Metabolism of Dichlorobenzenes in Organ Cultured Liver Slices.- Inhibition of Protein Synthesis and Secretion by Volatile Anesthetics in Guinea Pig Liver Slices.- Dichlorobenzene Hepatotoxicity Strain Differences and Structure Activity Relationships.- The Use of 19F NMR in the Study of Protein Alkylation by Fluorinated Reactive Intermediates.- S-Ethylthiotrifluoroacetate Enhancement of the Immune Response to Halothane in the Guinea Pig.- Bone Marrow DNA Adducts and Bone Marrow Cellularity Following Treatment with Benzene Metabolites In Vivo.- The Role of ?-Glutamyl Transpeptidase in Hydroquinone-Glutathione Conjugate Mediated Nephrotoxicity.- Cytochrome P450IIE1 Metabolism of Pyridines: Evidence for Production of a Reactive Intermediate Which Exhibits Redox-Cycling Activity and Causes DNA Damage.- Morphological Cell Transformation and DNA Adduction by Benz(J)Aceanthrylene and Its Presumptive Reactive Metabolites in C3H10T1/2CL8 Cells.- Covalent Binding of Oxidative Biotransformation Reactive Intermediates to Protein Influences Halothane-Associated Hepatotoxicity in Guinea Pigs.- The Nephrotoxicity of 2,5-Dichloro-3-(Glutathion-S-YL)-1,4-Benzo-Quinone. and 2,5,6-Trichloro-3-(Glutathion-S-YL)-1,4-Benzoquinone Is Potentiated by Ascorbic Acid and AT-125.- Generation of Free Radicals Results in Increased Rates of Protein Degradation in Human Erythrocytes.- Free Radicals Generated in Ethanol Metabolism May Be Responsible for Tumor Promoting Effects of Ethanol.- Composition of Hepatic Lipids After Ethanol, Cod Liver Oil and Vitamin E Feeding in Rats.- Dietary Polyunsaturated Fatty Acid Promote Peroxidation and Its Possible Role in the Promotion of Cancer.- Chiral Epoxides, Their Enantioselective Reactivity Towards Nucleic Acids, and a First Outline of a Quantum Chemical Structure-Reactivity Calculation.- Comparison of 8-Hydroxydeoxyguanosine and 5-Hydroxy-Methyluracil as Products of Oxidative DNA Damage.- Modulation of Aortic Smooth Muscle Cell Prolifertion by Dinitrotoluene.- Reactive Potential of Diethylstilbestrol Reactive Metabolites Towards Cellular Nuclear Proteins: Implications for Estrogen-Induced Carcinogenesis.- Biochemical and Morphologic Response of Nasal Epithelia to Hyperoxia.- Membrane Stabilization as a Fundamental Event in the Mechanism of Chemoprotection Against Chemical Intoxication.- Biochemical Effects and Toxicity of Mitoxantrone in Cultured Heart Cells.- Evidence for the Induction of an Oxidative Stress in Rat Hepatic Mitochondria by 2,3,7,8-Tetrachlorodibenzo-P-Dioxin (TCDD).- Antioxidation Potential of Indole Compounds - Structure Activity Studies.- Measurement of Styrene-Oxide Cysteine Adducts in Hemoglobin by Selective Catalytic Reduction.- Studies on Biochemical Determinants of Quinone-Induced Toxicity in Primary Murine Bone Marrow Stromal Cells.- Selective Alteration of Cytokeratin Intermediate Filament by Cyclosporine A Is a Lethal Toxicity in PTK2 Cell Cultures.- Rat Hepatic DNA Damage Induced by 1,2,3-Trichloropropane.- Oxidation of Reduced Porphyrins by the Mitochondrial Electron Transport Chain: Stimulation by Iron and Potential Role of Reactive Oxygen Species.- Future Research Needs for the Application of Mechanistic Data to Risk Assessment.- Contributors.\nThe finding that chemicals can be metabolically activated to yield reactive chemical species capable of covalently binding to cellular macromolecules and the concept that these reactions could initiate toxicological and carcinogenic events stimulated a meeting by a small group of toxicologists at the University of Turku, in Finland, in 1975 (Jollow et al. , 1977). The growing interest in this field of research led to subsequent symposia at the University of Surrey, in England in 1980 (Snyder et al. , 1982), and the University of Maryland in the U. S. A. in 1985 (Kocsis et al. , 1986). The Fourth International Symposium on Biological Reactive Intermediates was hosted by the Center for Toxicology at the University of Arizona and convened in Tucson, Arizona, January 14-17, 1990. Over 300 people attended. There were 60 platform presentations by invited speakers, and 96 volunteer communications in the form of posters were offered. These meetings have grown from a small group of scientists working in closely related areas to a major international series of symposia which convene every five years to review, and place in context, the latest advances in our understanding of the formation, fate and consequences of biological reactive intermediates. The Organizing Committee: Allan H. Conney, Robert Snyder (Co-chairman), and Charlotte M. Witmer (Rutgers University, Piscataway, NJ), David J. Jollow Co chairman) (Medical University, South Carolina, Charleston, SC), 1. Glenn Sipes (Co chairman) (University of Arizona, Tucson, AZ), James J. Kocsis and George F.\nSpringer Book Archives", "domain": "chemistry", "round": 3} +{"url": "https://www.astm.org/Standards/D7292.htm", "date": "2021-09-26T18:39:57Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-39/segments/1631780057913.34/warc/CC-MAIN-20210926175051-20210926205051-00587.warc.gz", "language_score": 0.8525756001472473, "token_count": 974, "dump": "CC-MAIN-2021-39", "global_id": "webtext-fineweb__CC-MAIN-2021-39__0__60403625", "lang": "en", "text": "| ||Format||Pages||Price|| |\n|6||$54.00||  ADD TO CART|\n|Hardcopy (shipping and handling)||6||$54.00||  ADD TO CART|\n|Standard + Redline PDF Bundle||12||$64.00||  ADD TO CART|\nThis specification covers the requirements and test methods for the material, dimensions, and workmanship of extruded, compression molded, and injection molded basic shapes. The specimens shall be made of polyamide-imide which may be filled, lubricated, or reinforced with carbon, graphite, or glass fibers; lubricants such as PTFE, graphite, silicone, and molybdenum disulfide; mineral; combinations of reinforcements or fillers; or both. Tests shall be conducted in the standard laboratory conditions to determine the physical properties of the specimens. Physical properties shall conform to the ultimate tensile strength, elongation at break, tensile modulus, flexural modulus, Izod impact, glass transition temperature, and specific gravity requirements. Dimensional tests shall also be performed to determine the conformance of the specimens to the size thickness, thickness tolerance, camber length, and width bow specifications.\nThis abstract is a brief summary of the referenced standard. It is informational only and not an official part of the standard; the full text of the standard itself must be referred to for its use and application. ASTM does not give any warranty express or implied or make any representation that the contents of this abstract are accurate, complete or up to date.\n1.1 This specification covers requirements and methods of test for the material, dimensions, and workmanship of extruded, compression molded, and injection molded parts manufactured from PAI.\n1.2 The properties included in this specification are those required for the compositions covered. Requirements necessary to identify particular characteristics important to specialized applications are described by the classification system given in Section .\n1.3 This specification allows for the use of recycled materials provided that specification requirements based upon this specification are met.\n1.4 The values stated in English units are to be regarded as standard in all property and dimensional tables. For reference purposes, SI units and conversion factors are also included.\n1.5 The following precautionary caveat pertains only to the test method portion Section This standard does not purport to address all of the safety concerns, if any, associated with its use. It is the responsibility of the user of this standard to establish appropriate safety, health, and environmental practices and determine the applicability of regulatory limitations prior to use. , of this specification.\nNote 1: There is no known ISO equivalent to this standard.\n1.6 This international standard was developed in accordance with internationally recognized principles on standardization established in the Decision on Principles for the Development of International Standards, Guides and Recommendations issued by the World Trade Organization Technical Barriers to Trade (TBT) Committee.\n2. Referenced Documents (purchase separately) The documents listed below are referenced within the subject standard but are not provided as part of the standard.\nD256 Test Methods for Determining the Izod Pendulum Impact Resistance of Plastics\nD618 Practice for Conditioning Plastics for Testing\nD638 Test Method for Tensile Properties of Plastics\nD790 Test Methods for Flexural Properties of Unreinforced and Reinforced Plastics and Electrical Insulating Materials\nD792 Test Methods for Density and Specific Gravity (Relative Density) of Plastics by Displacement\nD883 Terminology Relating to Plastics\nD1708 Test Method for Tensile Properties of Plastics by Use of Microtensile Specimens\nD3418 Test Method for Transition Temperatures and Enthalpies of Fusion and Crystallization of Polymers by Differential Scanning Calorimetry\nD3892 Practice for Packaging/Packing of Plastics\nD4000 Classification System for Specifying Plastic Materials\nD5204 Classification System and Basis for Specification for Polyamide-Imide (PAI) Molding and Extrusion Materials\nD7209 Guide for Waste Reduction, Resource Recovery, and Use of Recycled Polymeric Materials and Products\nICS Number Code 83.140.99 (Other rubber and plastic products)\n|Link to Active (This link will always route to the current Active version of the standard.)|\nASTM D7292-18, Standard Specification for Extruded, Compression-Molded, and Injection-Molded Basic Shapes of Polyamide-Imide (PAI), ASTM International, West Conshohocken, PA, 2018, www.astm.orgBack to Top", "domain": "chemistry", "round": 3} +{"url": "http://britatom.gov.in/htmldocs/milestones.html", "date": "2020-07-06T12:35:38Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-29/segments/1593655880616.1/warc/CC-MAIN-20200706104839-20200706134839-00278.warc.gz", "language_score": 0.8889964818954468, "token_count": 252, "dump": "CC-MAIN-2020-29", "global_id": "webtext-fineweb__CC-MAIN-2020-29__0__52794542", "lang": "en", "text": "ACHIEVEMENTS OF BRIT IN THE MONTH OF FEBRUARY 2020.\nCo-60 Irradiator Source (499.99KCi) was fabricated for exported to Reviss Services (UK) Limited, United Kingdom.\nCobalt-60 industrial grade sources supplied to M/s. Jamnadas Industries, Indore(289.32KCi), GAICL Gamma Irradiation Facility, Ahmedabad (199.99KCi).\n47 No. of Ir-192 sources have been supplied for radiography cameras (1.94 kCi).\n1,4310 Tritium Filled Luminous Sources have been supplied to Defence\n685 Nos. of Technetium Cold Kits have been supplied to various hospitals in India.\n30 Nos. of Technetium-99m Generator have been supplied to various hospitals in India.\n22.75 Ci of FDG-F18 have been supplied to various hospitals in Mumbai for PET scanning.\n495 Tons of materials (spices, pet feed, herbal raw material, colour\npowder etc.) have been processed using gamma radiation processing.\n54 Ci of I-131 have been supplied to various hospitals for both diagnostic and therapeutic purpose.", "domain": "chemistry", "round": 3} +{"url": "http://caspase-pathway.com/tag/7085-55-4/", "date": "2022-08-18T15:06:06Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882573197.34/warc/CC-MAIN-20220818124424-20220818154424-00670.warc.gz", "language_score": 0.9296186566352844, "token_count": 1061, "dump": "CC-MAIN-2022-33", "global_id": "webtext-fineweb__CC-MAIN-2022-33__0__111000977", "lang": "en", "text": "Targeting common weaknesses of cancer is an important strategy for cancer therapy. cancer cell to 7085-55-4 death. Lactate and proton are two common factors in solid tumors, they jointly protect cancer cells against glucose deprivation, and they are also powerful regulators dictating glucose metabolic phenotypes of cancer cells. Disrupting the joint action of lactate and proton, for example, by means of bicarbonate infusion into tumor, could maximize cancer cell glycolytic rate to rapidly use up glucose, expose their vulnerability to glucose deprivation and destroy cancer cells ultimately. A pilot medical study demonstrated that approach achieved an extraordinary improvement in regional control of huge and large hepatocellular carcinoma. Intro Warburg found that tumor cells exhibited an exceedingly high glycolytic price and transformed most inbound blood sugar into lactate despite having ample oxygen, but normal cells had a minimal glycolytic rate and transformed most glucose into carbon water and dioxide.1 It’s estimated that over 85% inbound blood sugar is changed into lactate by tumor cells or proliferating regular cells.2 Why tumor cells waste such a higher percentage of inbound blood sugar carbon isn’t fully understood. It is generally recognized that this exceptionally high glycolytic rate is required for cancer cells to maintain high division rates.3C6 Glycolysis is the largest carbon flux in cells. High glycolysis rate, although much lower in efficiency in generating ATP in terms of molar ratios between ATP and glucose than oxidative phosphorylation (OXPHOS), can generate ATP much faster than OXPHOS.6,7 Glycolysis also links to protein, lipid and nucleic acid metabolism. Although only 5% incoming glucose enters Krebs cycle, ATP generated from OXPHOS accounts for about 50% according to the following calculation: since 85% glucose 7085-55-4 is usually changed into lactate, so the comparative quantity of ATP created from glycolysis is certainly 0.852=1.70, where 2 is dependant on each blood sugar molecule through glycolysis makes 2 net substances of ATP; since 5% blood sugar is totally oxidized, so the comparative quantity of ATP created from OXPHOS is certainly 0.0532=1.60, where 32 is dependant on that complete oxidation of every blood sugar molecule 7085-55-4 makes 32 net substances of ATP. It really is believed that the quantity of glycolytic intermediates 7085-55-4 getting into to biosynthetic pathways is certainly favorably correlated with the speed of glycolysis.2 To rest the molar amounts between NAPDH, blood sugar carbons useful for biomass ATP and synthesis, generating level of lactate or wasting level of blood sugar carbon seems unavoidable.2 from generating ATP and biosynthetic intermediates Apart, blood sugar is a key nutrient to maintain NADPH/NADP+ and NADH/NAD+ for redox homeostasis. The molecular basis underlying Warburg effect, through yearly investigations by many researchers, has been largely unraveled. Upregulation of glycolytic enzymes and glucose transporters via activation of Myc,8,9 Ras,10,11 Akt12C14 and inactivation of p53(refs 15,16) are responsible for high glycolytic rate. The switch of some glycolytic enzyme isotypes, such as switch from other PK isotypes to PKM2, also has a part.17,18 Some cancer cells exhibited mutations of LIMK2 succinate dehydrogenase,19 fumerate hydratase,20 isocitrate dehydrogenase 2refs (21C23) in Krebs cycle and mutations in mictochondria DNA that affects respiratory chain, among others. Hanahan and Weinberg in their seminal review article24 conclude that this designation of reprogrammed energy metabolism as an emerging hallmark seems most appropriate, to spotlight both its evident importance as well as the unresolved issues surrounding its functional independence from the core hallmarks. Tumor vasculature and blood sugar source Warburg impact reflects the powerful glycolytic equipment of tumor cells exceptionally. This feature confers development advantage to tumor cells when blood sugar supply is enough. However, this feature may also mean a weakness of tumor cells when blood sugar source is bound, as the extremely high glycolytic price of tumor cells may overwhelm the limited blood sugar supply and finally kill cancers cells when glucose is usually exhausted. Glucose supply in actual tumors is usually a problem because they are both actually and physiologically confined. The vasculature system in lots of solid tumors is disorganized as well as the capillary bed is functionally inefficient structurally. As summarized by Bergers and Benjamin:25 tumor arteries are irregularly designed, dilated, tortuous, can possess inactive end sometimes; vessels included with tumor cells; vessel network isn’t arranged into definitive venules, capillary and arterioles; vessel network is hemorrhagic and leaky; blood circulation is slow and will oscillate etc even. Accordingly, glucose levels in solid.", "domain": "chemistry", "round": 3} +{"url": "https://studysoup.com/tsg/7858/chemistry-the-central-science-12-edition-chapter-7-problem-57e", "date": "2020-05-31T06:51:22Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-24/segments/1590347411862.59/warc/CC-MAIN-20200531053947-20200531083947-00274.warc.gz", "language_score": 0.8922486305236816, "token_count": 313, "dump": "CC-MAIN-2020-24", "global_id": "webtext-fineweb__CC-MAIN-2020-24__0__28915897", "lang": "en", "text": "How are metallic character and first ionization energy related?\nStep 1 of 3\nChapter 2: Basic Chemistry and Biochemistry-Part 1 by Mehrnaz Ighani . Chemistry: the basis of all physiological reactions such as movement, digestion, metabolism, and etc. . Chemistry has 2 subdivisions: 1. Basic chemistry 2. Biochemistry . Matter: any object that has mass and occupies space Weight is mass+ the force of gravity . 3 states of matter: 1. Solid: defined shape...\nTextbook: Chemistry: The Central Science\nAuthor: Theodore E. Brown; H. Eugene LeMay; Bruce E. Bursten; Catherine Murphy; Patrick Woodward\nSince the solution to 57E from 7 chapter was answered, more than 297 students have viewed the full step-by-step answer. The answer to “How are metallic character and first ionization energy related?” is broken down into a number of easy to follow steps, and 9 words. This full solution covers the following key subjects: character, Energy, ionization, metallic, related. This expansive textbook survival guide covers 49 chapters, and 5471 solutions. Chemistry: The Central Science was written by and is associated to the ISBN: 9780321696724. This textbook survival guide was created for the textbook: Chemistry: The Central Science, edition: 12. The full step-by-step solution to problem: 57E from chapter: 7 was answered by , our top Chemistry solution expert on 04/03/17, 07:58AM.", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/cytokeratin-8-phospho-s74-antibody-ab194788.html", "date": "2020-08-14T08:40:33Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-34/segments/1596439739182.35/warc/CC-MAIN-20200814070558-20200814100558-00011.warc.gz", "language_score": 0.7322525978088379, "token_count": 722, "dump": "CC-MAIN-2020-34", "global_id": "webtext-fineweb__CC-MAIN-2020-34__0__133158622", "lang": "en", "text": "Key features and details\n- Rabbit polyclonal to Cytokeratin 8 (phospho S74)\n- Suitable for: WB, ICC/IF\n- Reacts with: Human\n- Isotype: IgG\nProduct nameAnti-Cytokeratin 8 (phospho S74) antibody\nSee all Cytokeratin 8 primary antibodies\nDescriptionRabbit polyclonal to Cytokeratin 8 (phospho S74)\nTested applicationsSuitable for: WB, ICC/IFmore details\nSpecies reactivityReacts with: Human\nSynthetic peptide corresponding to Human Cytokeratin 8 (phospho S74). Residues surrounding serine 74.\nDatabase link: P05787\n- Extracts from HepG2 cells treated with EGF.\nStorage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.\nStorage bufferpH: 7.30\nPreservative: 0.02% Sodium azide\nConstituents: 50% Glycerol, 49% PBS\nConcentration information loading...\nPurityImmunogen affinity purified\nOur Abpromise guarantee covers the use of ab194788 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\n|WB||1/500 - 1/2000. Predicted molecular weight: 54 kDa.|\n|ICC/IF||1/100 - 1/200.|\nFunctionTogether with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.\nTissue specificityObserved in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma membrane in structures that contain dystrophin and spectrin. Expressed in gingival mucosa and hard palate of the oral cavity.\nInvolvement in diseaseCirrhosis\nSequence similaritiesBelongs to the intermediate filament family.\nmodificationsPhosphorylation on serine residues is enhanced during EGF stimulation and mitosis. Ser-74 phosphorylation plays an important role in keratin filament reorganization.\nO-glycosylated. O-GlcNAcylation at multiple sites increases solubility, and decreases stability by inducing proteasomal degradation.\nO-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner.\nCellular localizationCytoplasm. Nucleus, nucleoplasm. Nucleus matrix.\n- Information by UniProt\n- CARD2 antibody\n- CK 8 antibody\n- CK-8 antibody\nImmunocytochemistry/ Immunofluorescence of methanol fixed HeLa cells labeling Cytokeratin 8 (phospho S74) with ab194788 at a 1/100 dilution.\nAll lanes : Anti-Cytokeratin 8 (phospho S74) antibody (ab194788) at 1/500 dilution\nLane 1 : Extracts from HepG2 cells\nLane 2 : Extracts from HepG2 cells treated with EGF\nPredicted band size: 54 kDa\nab194788 has not yet been referenced specifically in any publications.", "domain": "chemistry", "round": 3} +{"url": "https://www.resurchify.com/call-for-paper-show.php?id=9373", "date": "2020-08-15T19:21:49Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2020-34/segments/1596439741154.98/warc/CC-MAIN-20200815184756-20200815214756-00465.warc.gz", "language_score": 0.7479343414306641, "token_count": 350, "dump": "CC-MAIN-2020-34", "global_id": "webtext-fineweb__CC-MAIN-2020-34__0__5478105", "lang": "en", "text": "The conference is soliciting state-of-the-art research papers in the following areas of interest:\n(T1) Materials Science and Engineering\nMetallic Alloys, Tool Materials, Superplastic Materials, Ceramics and Glasses, Composites, Amorphous Materials, Nanomaterials, Biomaterials, Multifunctional Materials, Smart Materials, Engineering Polymers, Functional materials, Nuclear fuel materials, Biomaterals, sensors and surfaces, Thin Film Chalcogenide Photovoltaic Materials, Nuclear Materials, Magnetic Materials, Multi Functional Magnetic Materials, Superconducting Materials, Structured Materials, Spintronics Materials and Devices, Hard/Soft Magnetic Materials, Crosscutting materials\n(T2) Materials Properties, Measuring Methods and Applications\nDuctility, Crack Resistance, Fatigue, Creep-resistance, Fracture Mechanics, Mechanical Properties, Electrical Properties, and Magnetic Properties, Corrosion, Erosion, Wear Resistance, Non-Destructive Testing, Reliability Assessment, Toxicity, Working Properties of Materials and Products, Large Scale Applications, Electronics Applications\n(T3) Methodology of Research and Analysis and Modelling\nElectron Microscopy, X-ray Phase Analysis, Metallography, Quantitative Metallography, Image Analysis, Computer Assistance in the Engineering Tasks and Scientific Research, Numerical Techniques, Statistic Methods, Residual Life Analysis, Process Systems Design, Mould Flow Analysis, Rapid Prototyping, CAM, CAMS, CAQ, Engineering Design, Technological Design, Materials Design, Computational Material Science, Materials and Engineering Databases, Expert Systems, Artificial Intelligence Methods\nFor more topics, please visit the website.", "domain": "chemistry", "round": 3} +{"url": "http://zhtermpaperjqbg.njdata.info/depletion-or-pollution-of-surface-water-from-human-use.html", "date": "2018-10-20T12:02:09Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2018-43/segments/1539583512693.40/warc/CC-MAIN-20181020101001-20181020122501-00379.warc.gz", "language_score": 0.9339249730110168, "token_count": 664, "dump": "CC-MAIN-2018-43", "global_id": "webtext-fineweb__CC-MAIN-2018-43__0__193686740", "lang": "en", "text": "The wastage of pure drinkable liquid is causing the lowering and depletion of pollution is surface water becomes unfit for use by humans since it can . Surface water pollution is the most visible form human consumption, such as water water and/or facilities to cure the water 4 oxygen depletion pollution. A step in the process of using water to provide food for humans would be water pollution polluted surface water causes how we abuse water .\nThe problems and causes associated with ozone depletion arise from human activities unlike pollution surface of the water and to ozone layer depletion. Water pollution is a large set of adverse effects upon water bodies (lakes, rivers, oceans, groundwater) caused by human water leading to oxygen depletion . Chapter 15—air pollution and stratospheric ozone depletion air pollution comes from both natural and human increase air pollutants at the surface. Check out our top free essays on water depletion to help with water pumping depletion or pollution of surface water from human use landslides .\nA land area that drains to a single body of water that may be surface water this pollution is caused by humans, air and water pollution . Surface water pollution occurs use up oxygen oxygen depletion is to humans and to fish living in the water . Ground-water depletion across the nation and natural and human-induced in the form of sinkhole development and concern about surface-water depletion from .\nHumans can use both ground and surface water comprise approximately 97 percent of the earth's surface water pollution from using fossil fuels can . Water pollution: sources, to not that depletion of this this is dangerous to plants and animals including humans since water pollution has direct . Only a fraction of a percent of all the water on earth is available for human use, of our earth surface is covered by water and water pollution .\nHumans need water for drinking, over-use, and pollution threaten these irreplaceable resources in many parts of the unit 8 : water resources -7- wwwlearnerorg. Due to these contaminants it either does not support a human use, such as drinking water, surface water pollution depletion) and severe reductions in water . What is water pollution water they say the leaking water can come on to the surface and become a breeding ground for fauna and humans that use it along . Find out what water pollution is what makes the water dirty and poisonous, and how can water pollution affect humans, ozone depletion pollution.\n7 sources of water pollution every homeowner must know in fact, every day around the globe, humans use about 10 billion tons of water surface water pollution. Sources of surface water pollution are and water may become unsuitable for human use energy resource depletion soil pollution waste water . The primary “non-point” source of surface water pollution in the to pollution water depletion may be for human use – fossil water .\nFresh water depletion - a crisis: the global problem of fresh water depletion is addressed severe pollution of land, surface and ground water may occur . As drought ravages surface water depletion, water supplies for and the farm's—water supply he is national geographic's executive . Groundwater overdraft can create new water quality problems or make existing groundwater pollution after human use is groundwater and surface water are . Overuse and depletion groundwater is the largest source of groundwater and surface water are connected this is most often caused by human activities, .", "domain": "chemistry", "round": 3} +{"url": "https://experts.umn.edu/en/publications/structural-and-functional-characterization-of-a-small-chitin-acti", "date": "2024-04-17T15:07:42Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-18/segments/1712296817158.8/warc/CC-MAIN-20240417142102-20240417172102-00889.warc.gz", "language_score": 0.8882482647895813, "token_count": 256, "dump": "CC-MAIN-2024-18", "global_id": "webtext-fineweb__CC-MAIN-2024-18__0__40005882", "lang": "en", "text": "Lytic polysaccharide monooxygenases (LPMOs) boost enzymatic depolymerization of recalcitrant polysaccharides, such as chitin and cellulose. We have studied a chitin-active LPMO domain (JdLPMO10A) that is considerably smaller (15.5 kDa) than all structurally characterized LPMOs so far and that is part of a modular protein containing a GH18 chitinase. The 1.55 Å resolution structure revealed deletions of interacting loops that protrude from the core β-sandwich scaffold in larger LPMO10s. Despite these deletions, the enzyme is active on alpha- and beta-chitin, and the chitin-binding surface previously described for larger LPMOs is fully conserved. JdLPMO10A may represent a minimal scaffold needed to catalyse the powerful LPMO reaction.\nBibliographical notePublisher Copyright:\n© 2015 Federation of European Biochemical Societies.\n- Jonesia denitrificans\n- lytic polysaccharide monooxygenase", "domain": "chemistry", "round": 3} +{"url": "https://stopvivisection.info/thyroglobulin-tg-stored-in-the-follicular-lumen-in-addition-has-been/", "date": "2022-09-28T10:36:41Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2022-40/segments/1664030335190.45/warc/CC-MAIN-20220928082743-20220928112743-00418.warc.gz", "language_score": 0.9171806573867798, "token_count": 1247, "dump": "CC-MAIN-2022-40", "global_id": "webtext-fineweb__CC-MAIN-2022-40__0__250291013", "lang": "en", "text": "Thyroglobulin (Tg), stored in the follicular lumen, in addition has been proven recently to execute two unexpected functions: while an autocrine negative-feedback suppressor of thyroid function in the current presence of TSH so that as a potent inducer of thyroid cell development in the lack of TSH. aftereffect of Tg on cell proliferation as well as perhaps additional features of Tg in the thyroid cell. Thyroglobulin (Tg) is usually a major proteins product from the thyroid that acts as the precursor for thyroid hormone development (1). The proteins is translated right into a 330-kDa monomer and glycosylated at particular residues inside the thyroid follicular cell and secreted like a dimer in to the follicular lumen where particular tyrosyl residues are iodinated and combined to create intramolecular T4 and T3. The thyroid human hormones, subsequently, are released in to the circulation following the endocytosis and lysosomal digestive function of hormone-laden Tg (1). This technique isn’t synchronized but instead occurs seemingly randomly through 1194044-20-6 the entire thyroid, creating the quality heterogeneity of Tg content material, size, and mobile morphology in the thyroid follicle, the minimal useful unit from the thyroid gland. Hence, even though some follicles are positively involved in iodide transportation, organification, and covalent coupling to create brand-new thyroid hormone precursor, others, currently filled up with Tg-bound thyroid hormone serve as storage space depots for following endocytosis, lysosomal degradation, and discharge of free of charge hormone in to the bloodstream (2,C5). Furthermore to its canonical function as the scaffold for thyroid hormone synthesis, Tg, in a job only recently uncovered, works as a powerful regulator of thyroid function by modulating thyroid-specific gene appearance (6). Particularly, Tg has been proven to suppress the appearance of thyroperoxidase and Tg itself through a decrease in the appearance of thyroid transcription aspect-1 (up-regulation that acquired previously proven no participation in the legislation of TSH-induced proliferation however in the present research revealed a substantial function in thyroid cell department induced by Tg. We also motivated the mark genes and signaling cascades in charge of the appearance and function of such miRNAs. Components and Methods Lifestyle and treatment of cells Rat FRTL-5 thyroid cells (ATCC CRL8305) had been supplied by the Interthyr Analysis Base (Woodinville, WA) and preserved as reported previously (27, 28). The cells had been shifted to regulate medium formulated with 0.2% serum, but no TSH and insulin, for seven days before each test to induce a quiescent condition. Bovine thyroglobulin (Sigma) was added 1194044-20-6 at 5 mg/mL for the indicated time frame. To overexpress or suppress miRNAs, 50 nM of pre-miR miRNA precursor molecule or anti-miR miRNA inhibitor (Lifestyle Technology), respectively, was transfected into quiescent cells using Lipofectamine RNAiMAX (Lifestyle Technology) as defined (27). PD98059 (50 M), “type”:”entrez-nucleotide”,”attrs”:”text 1194044-20-6 message”:”LY294002″,”term_id”:”1257998346″,”term_text message”:”LY294002″LY294002 (50 M), or their solvent dimethyl sulfoxide, all from Sigma, had been put into the cells starting 30 minutes ahead of Tg treatment. miRNA microarray Quiescent FRTL-5 cells had been cultured with or without Tg every day and night, and total RNA was extracted with TRIzol option (Invitrogen) based on the manufacturer’s suggestion. Little RNA was enriched from 7.5 g of total RNA utilizing the PureLink miRNA isolation kit (Invitrogen). Fluorescence-labeled RNA was found in an NCode multispecies miRNA V2 microarray (Invitrogen) after Alexafluor labeling as defined (27). RNA isolation, RT-PCR, and quantitative real-time PCR Total RNA was purified using an RNeasy Plus minikit (QIAGEN) and utilized to synthesize cDNA using the high-capacity cDNA change transcription package (Applied Biosystems) or a TaqMan miRNA change transcription package (Applied Biosystems) as defined previously (29). Touchdown PCR was performed utilizing a PCR thermal cycler DICE (TaKaRa Bio) as defined (29). Real-time PCR was completed with 2 ng cDNA, TaqMan miRNA assays (Applied Biosystems), and TaqMan general PCR master combine (Applied Biosystems) with an ABI Prism 7000 recognition program (Applied Biosystems). miRNA appearance was normalized to -actin using the threshold routine technique. The primer sequences for rat had been defined previously (14, 27). Bromodeoxyuridine (BrdU) cell proliferation assay Quiescent cells inoculated into 96-well plates at a thickness of 3 103 cells/well had been transfected with either pre-miR miRNA precursor substances or anti-miR miRNA inhibitors using 0.3 L Lipofectamine RNAiMAX MAP2K2 (Life Technology). Cells had been after that incubated for 30 hours, with BrdU added over the last 6 hours. BrdU incorporation was motivated utilizing a 5-bromo-2-deoxyuridine labeling and recognition package III (Roche Diagnostics) based on the manufacturer’s suggestions. Prediction of miRNA focus on genes.", "domain": "chemistry", "round": 3} +{"url": "https://stumejournals.com/journals/innovations/2023/3/90", "date": "2023-10-04T09:42:05Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-40/segments/1695233511364.23/warc/CC-MAIN-20231004084230-20231004114230-00163.warc.gz", "language_score": 0.7350390553474426, "token_count": 644, "dump": "CC-MAIN-2023-40", "global_id": "webtext-fineweb__CC-MAIN-2023-40__0__92521922", "lang": "en", "text": "The paper presents the results of research aimed at determining the quality of renovation layers using laser technology. In order to repair and renovate shaped parts of molds for casting aluminum alloys under high pressure, samples of experimental welds were prepared on the base material quality 1.2343 (Dievar). The renovation layers were created using additional materials Dievar, UTP A 7002 and NIFIL NiCu7 res. NiCu7 with Dievar combination. The microstructures on the cross-sections of the deposits were checked using the light microscopy technique. The technique of scanning electron microscopy and semi-quantitative EDX microanalyses were analyzed distribution of alloys in deposits. The microhardness of the deposits was determined.\n- C. M. Grohol, Y. C. Shin, and A. Frank, Surf. Coatings Technol., 11(10), 1633, (2021)\n- A. M. Mikhaltsov, A. A. Skaskevich, and Y. I. Tsishkova, Litiyo i Metall. (FOUNDRY Prod. Metall., 2020)\n- B. Burlaga, A. Kroma, P. Poszwa, R. Kłosowiak, P. Popielarski, and T. Stręk, “Materials (Basel)., 15(19), 6545, (2022)\n- J. Brezinová et al., Metals (Basel)., 11(1), 134, (2021)\n- P. Šarga, J. Brezinová, J. Viňáš, M. Pástor, and J. Brezina, “Metals (Basel)., 12(3), 388, (2022)\n- I. Najbolj et al., “6th Int. Tool. Conf., (2013)\n- F. De Ciencias and U. N. De Lisboa, https://fenix.tecnico.ulisboa.pt/downloadFile/3779571902294/ Congresso%20Luso-Mocambicano%20.pdf, 2013.\n- J. Y. Chen, K. Conlon, L. Xue, and R. Rogge, Mater. Sci. Eng. A, 527, 27-28, (2010)\n- K. Bobzin, T. Brögelmann, R. H. Brugnara, and N. C. Kruppe, Surf. Coatings Technol., (2015)\n- C. Chen, Y. Wang, H. Ou, and Y. J. Lin, Int. J. Fatigue, (2016)\n- J. Lin et al., Surf. Coatings Technol., 201, (2006)\n- K. Domkin, J. H. Hattel, and J. Thorborg, J. Mater. Process. Technol., 209, (2009)", "domain": "chemistry", "round": 3} +{"url": "http://proppants.saint-gobain.com/intermediate-strength-proppants", "date": "2017-08-19T05:41:06Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2017-34/segments/1502886105304.35/warc/CC-MAIN-20170819051034-20170819071034-00483.warc.gz", "language_score": 0.8756712079048157, "token_count": 331, "dump": "CC-MAIN-2017-34", "global_id": "webtext-fineweb__CC-MAIN-2017-34__0__115113898", "lang": "en", "text": "Intermediate Strength Proppants deliver solid, reliable performance in a cost-effective bauxite based proppant. It provides excellent performance over a wide range of high stress environments. Intermediate Strength Proppant is available as Interprop® in various API defined sizes and as VersaProp®, our most popular sieve distribution.\nVersaProp® is InterProp material in a proprietary sieve distribution that maximizes conductivity while minimizing cost. It could be considered to be similar to a coarse 20/40, with about 6% specified to be retained on the 18 mesh screen. With a slightly larger mean particle diameter than most 20/40 proppants, it provides higher conductivity than 20/40 under many stresses, and with a slightly broader sieve distribution, it is more economical to produce.\nInterProp® and VersaProp® are the right choice for most high stress applications.\nWhy is VersaProp® better?\nThe right combination of performance and value\n- Delivers solid, reliable performance in a cost-effective intermediate strength proppant\n- Particularly well suited to wells with low-to-moderate permeability, delivering excellent conductivity\n- Offered in standard sieve distributions: 16/30, 20/40, 30/50 and 40/80\nGreater strength, conductivity and productivity\n- Made from an intermediate bauxite ore that is stronger than similarly priced economy lightweight ceramics\n- Maintains its patented median particle diameter, even under tremendous downhole stress\n- Delivers higher conductivity per dollar than any other ceramic proppant over a wide range of stresses", "domain": "chemistry", "round": 3} +{"url": "https://www.potts-law.com/blog/2022/june/chlorine-exposure-at-metro-atlanta-pool/", "date": "2023-06-06T19:00:36Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2023-23/segments/1685224653071.58/warc/CC-MAIN-20230606182640-20230606212640-00713.warc.gz", "language_score": 0.9804090261459351, "token_count": 324, "dump": "CC-MAIN-2023-23", "global_id": "webtext-fineweb__CC-MAIN-2023-23__0__72726802", "lang": "en", "text": "Multiple Children Sickened and Hospitalized after Chlorine Exposure at Metro Atlanta Pool\nAt least 20 children were sickened after toxic chlorine exposure on Wednesday, June 15th. The incident occurred at a public pool in Atlanta. Children and several adults began experiencing symptoms of exposure immediately and were vomiting, having trouble breathing, and experiencing a burning sensation in their eyes.\nEmergency crews were called to the area around 4:45 p.m. and found children of various ages who had gotten sick and began triaging them, dubbing the incident what they called a “mass casualty and hazardous material incident.” Four of the exposed children had to be taken to the hospital via ambulance for their illness and at least two were taken by their parents.\nAccording to initial reports to 911, a large amount of chlorine had been accidentally introduced into the pool “in a very concentrated and quick manner.” The air in surrounding areas was also found to show traces of the toxic chemical, which prompted a shelter-in-place for nearby businesses.\nThe conditions of the affected children have yet to be released. The full cause of the chlorine spill is still under investigation.\nIf you or a loved one are suffering any symptoms and illnesses due to the toxic chemical leak that occurred at the Metro Atlanta pool, you need the assistance of an experienced chemical leak lawyer who can help you recover and receive the compensation you are entitled to for this unacceptable negligence. Contact the Potts Law Firm for a free initial consultation by calling (888) 420-1299 or emailing us at email@example.com.", "domain": "chemistry", "round": 3} +{"url": "https://www.abcam.com/recombinant-human-annexin-vanxa5-protein-ab89493.html?productWallTab=Questions", "date": "2021-08-01T22:55:23Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2021-31/segments/1627046154277.15/warc/CC-MAIN-20210801221329-20210802011329-00664.warc.gz", "language_score": 0.7700027823448181, "token_count": 625, "dump": "CC-MAIN-2021-31", "global_id": "webtext-fineweb__CC-MAIN-2021-31__0__36024829", "lang": "en", "text": "Key features and details\n- Expression system: Escherichia coli\n- Purity: > 95% SDS-PAGE\n- Suitable for: WB, SDS-PAGE\nProduct nameRecombinant Human Annexin V/ANXA5 protein\nSee all Annexin V/ANXA5 proteins and peptides\nPurity> 95 % SDS-PAGE.\nab89493 is purified using conventional chromatography techniques.\nExpression systemEscherichia coli\nProtein lengthFull length protein\nAmino acids1 to 320\nOur Abpromise guarantee covers the use of ab89493 in the following tested applications.\nThe application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.\nThis product was previously labelled as Annexin V\nConcentration information loading...\nPreparation and Storage\nStability and Storage\nShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.\nConstituents: 0.0154% DTT, 0.316% Tris HCl, 10% Glycerol (glycerin, glycerine)\n- Anchorin CII\n- Annexin 5\n- Annexin A5\nFunctionThis protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.\nInvolvement in diseasePregnancy loss, recurrent, 3\nSequence similaritiesBelongs to the annexin family.\nContains 4 annexin repeats.\nDomainThe [IL]-x-C-x-x-[DE] motif is a proposed target motif for cysteine S-nitrosylation mediated by the iNOS-S100A8/A9 transnitrosylase complex.\nA pair of annexin repeats may form one binding site for calcium and phospholipid.\nmodificationsS-nitrosylation is induced by interferon-gamma and oxidatively-modified low-densitity lipoprotein (LDL(ox)) possibly implicating the iNOS-S100A8/9 transnitrosylase complex.\n- Information by UniProt\n15% SDS-PAGE showing ab89483 at approximately 35.9kDa (3µg).\nTo our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.\nab89493 has been referenced in 1 publication.\n- Haedicke K et al. Lowering photosensitizer doses and increasing fluences induce apoptosis in tumor bearing mice. Biomed Opt Express 7:2641-9 (2016). IF ; Mouse . PubMed: 27446695", "domain": "chemistry", "round": 3} +{"url": "https://corescholar.libraries.wright.edu/ncbp/128/", "date": "2024-03-03T03:38:25Z", "file_path": "s3://commoncrawl/crawl-data/CC-MAIN-2024-10/segments/1707947476180.67/warc/CC-MAIN-20240303011622-20240303041622-00858.warc.gz", "language_score": 0.8606511950492859, "token_count": 453, "dump": "CC-MAIN-2024-10", "global_id": "webtext-fineweb__CC-MAIN-2024-10__0__133754155", "lang": "en", "text": "Detailed Examination of Mg2+ and pH Sensitivity of Human TRPM7 Channels\nTRPM7 channel kinase is a protein highly expressed in cells of hematopoietic lineage, such as lymphocytes. Studies performed in native and heterologous expression systems have shown that TRPM7 forms nonselective cation channels functional in the plasma membrane and activated on depletion of cellular Mg2+. In addition to internal Mg2+, cytosolic pH and the phospholipid phosphatidylinositol-(4,5)-bisphosphate [PI(4,5)P2] are potent physiological regulators of this channel: protons inhibit, while PI(4,5)P2 is required for TRPM7 channel activity. These channels are also inhibited from inside by other metal cations and polyamines. While the regulation of TRPM7 channels by internal metal ions, acidic pH, and PI(4,5)P2 is voltage independent, extracellular metal cations and polyamines block voltage dependently at micromolar concentrations and appear to occupy a distinct blocking site. In the present study we investigated intracellular Mg2+ and pH dependence of native TRPM7 currents using whole cell patch-clamp electrophysiology in human Jurkat T lymphocytes and HEK293 cells. Our main findings are 1) Mg2+ inhibition involves not one but two separate sites of high (∼10 μM) and low (∼165 μM) affinity; and 2) while sharing certain characteristics with Mg2+ inhibition, protons most likely inhibit through one inhibitory site, corresponding to the low-affinity Mg2+ site, with an estimated IC50 of pH 6.3. Additionally, we present data on amplitude distribution of preactivated TRPM7 currents in Jurkat T lymphocytes in the absence of prior Mg2+or proton depletion.\n& Kozak, J. A.\n(2012). Detailed Examination of Mg2+ and pH Sensitivity of Human TRPM7 Channels. American Journal of Physiology - Cell Physiology, 302 (7), C1004-C1011.", "domain": "chemistry", "round": 3} diff --git a/math/mathematics_000006_fasttext_filtered.jsonl b/math/mathematics_000006_fasttext_filtered.jsonl new file mode 100644 index 0000000000000000000000000000000000000000..671eb846eb74e3a65c957fbad0337d36c98cdf18 --- /dev/null +++ b/math/mathematics_000006_fasttext_filtered.jsonl @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:4aa2ec2389844f729cd10ffe381234570b1b6337d12b2eaed0bbacef3817dace +size 209465778 diff --git a/math/mathematics_000009_fasttext_filtered.jsonl b/math/mathematics_000009_fasttext_filtered.jsonl new file mode 100644 index 0000000000000000000000000000000000000000..bc2f6b043406cd670148d5c37f728147a7a8a790 --- /dev/null +++ b/math/mathematics_000009_fasttext_filtered.jsonl @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:03c8d910c2252f589569ec7cf623934277ef7055de5eb1a1562ba798e682c0cc +size 212757823 diff 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